data_UZO
# 
_chem_comp.id                                    UZO 
_chem_comp.name                                  "1-[[(2~{R},3~{S},4~{R},5~{R})-5-[8-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]prop-1-ynyl]-6-azanyl-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-3-(phenylmethyl)urea" 
_chem_comp.type                                  non-polymer 
_chem_comp.pdbx_type                             HETAIN 
_chem_comp.formula                               "C34 H42 N14 O7" 
_chem_comp.mon_nstd_parent_comp_id               ? 
_chem_comp.pdbx_synonyms                         ? 
_chem_comp.pdbx_formal_charge                    0 
_chem_comp.pdbx_initial_date                     2023-09-07 
_chem_comp.pdbx_modified_date                    2025-03-14 
_chem_comp.pdbx_ambiguous_flag                   N 
_chem_comp.pdbx_release_status                   REL 
_chem_comp.pdbx_replaced_by                      ? 
_chem_comp.pdbx_replaces                         ? 
_chem_comp.formula_weight                        758.787 
_chem_comp.one_letter_code                       ? 
_chem_comp.three_letter_code                     UZO 
_chem_comp.pdbx_model_coordinates_details        ? 
_chem_comp.pdbx_model_coordinates_missing_flag   N 
_chem_comp.pdbx_ideal_coordinates_details        Corina 
_chem_comp.pdbx_ideal_coordinates_missing_flag   N 
_chem_comp.pdbx_model_coordinates_db_code        8QGI 
_chem_comp.pdbx_subcomponent_list                ? 
_chem_comp.pdbx_processing_site                  PDBE 
_chem_comp.pdbx_pcm                              ? 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.alt_atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.charge 
_chem_comp_atom.pdbx_align 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_leaving_atom_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_backbone_atom_flag 
_chem_comp_atom.pdbx_n_terminal_atom_flag 
_chem_comp_atom.pdbx_c_terminal_atom_flag 
_chem_comp_atom.model_Cartn_x 
_chem_comp_atom.model_Cartn_y 
_chem_comp_atom.model_Cartn_z 
_chem_comp_atom.pdbx_model_Cartn_x_ideal 
_chem_comp_atom.pdbx_model_Cartn_y_ideal 
_chem_comp_atom.pdbx_model_Cartn_z_ideal 
_chem_comp_atom.pdbx_component_atom_id 
_chem_comp_atom.pdbx_component_comp_id 
_chem_comp_atom.pdbx_ordinal 
UZO N1  N1  N 0 1 N N N N N N 14.139 9.435  11.968 -2.217 -2.991 -0.987 N1  UZO 1  
UZO C7  C1  C 0 1 Y N N N N N 20.296 12.388 12.273 4.606  -4.295 -0.987 C7  UZO 2  
UZO C8  C2  C 0 1 Y N N N N N 21.344 13.174 11.758 5.917  -4.758 -1.201 C8  UZO 3  
UZO N2  N2  N 0 1 Y N N N N N 18.916 12.492 12.161 3.399  -4.590 -1.519 N2  UZO 4  
UZO C9  C3  C 0 1 Y N N N N N 22.801 11.672 12.742 6.660  -3.305 0.432  C9  UZO 5  
UZO O1  O1  O 0 1 N N N N N N 15.914 5.046  13.090 5.473  2.918  2.497  O1  UZO 6  
UZO C1  C4  C 0 1 N N N N N N 11.757 9.268  12.750 -2.369 -1.334 -2.783 C1  UZO 7  
UZO O5  O2  O 0 1 N N N N N N 17.800 10.385 7.902  -7.676 -1.427 0.947  O5  UZO 8  
UZO C5  C5  C 0 1 N N N N N N 17.088 11.073 12.889 1.080  -3.889 -1.258 C5  UZO 9  
UZO C6  C6  C 0 1 Y N N N N N 18.459 11.443 12.817 2.478  -3.850 -0.948 C6  UZO 10 
UZO N3  N3  N 0 1 N N N N N N 21.159 14.278 11.024 6.178  -5.733 -2.147 N3  UZO 11 
UZO C4  C7  C 0 1 N N N N N N 15.911 10.873 12.871 -0.066 -3.920 -1.511 C4  UZO 12 
UZO O4  O3  O 0 1 N N N N N N 15.846 8.439  9.855  -4.230 -1.088 -0.007 O4  UZO 13 
UZO C3  C8  C 0 1 N N N N N N 14.484 10.512 12.892 -1.503 -3.960 -1.829 C3  UZO 14 
UZO O3  O4  O 0 1 N N N N N N 19.312 10.215 16.510 1.102  -3.162 2.620  O3  UZO 15 
UZO C2  C9  C 0 1 N N N N N N 13.049 8.552  12.404 -1.875 -1.613 -1.363 C2  UZO 16 
UZO N4  N4  N 0 1 Y N N N N N 22.609 12.777 12.017 6.899  -4.236 -0.473 N4  UZO 17 
UZO N   N5  N 0 1 N N N N N N 11.284 7.533  14.462 -2.552 0.397  -4.507 N   UZO 18 
UZO C   C10 C 0 1 N N N N N N 10.728 8.335  13.362 -1.982 0.090  -3.188 C   UZO 19 
UZO O   O5  O 0 1 N N N N N N 18.668 8.458  13.443 3.095  -0.814 0.872  O   UZO 20 
UZO C10 C11 C 0 1 Y N N N N N 20.650 11.272 13.011 4.404  -3.302 -0.011 C10 UZO 21 
UZO C11 C12 C 0 1 N N S N N N 19.325 9.470  14.185 2.368  -2.062 0.842  C11 UZO 22 
UZO C12 C13 C 0 1 N N R N N N 17.893 7.631  14.345 2.643  -0.139 2.066  C12 UZO 23 
UZO C13 C14 C 0 1 N N N N N N 16.426 7.650  13.959 3.661  0.918  2.498  C13 UZO 24 
UZO C14 C15 C 0 1 N N N N N N 15.835 5.965  12.277 4.675  2.935  1.580  C14 UZO 25 
UZO C15 C16 C 0 1 N N N N N N 14.840 4.506  10.570 5.694  5.010  0.809  C15 UZO 26 
UZO C16 C17 C 0 1 Y N N N N N 13.456 4.624  9.978  5.511  6.000  -0.312 C16 UZO 27 
UZO C17 C18 C 0 1 Y N N N N N 12.472 5.369  10.614 4.664  7.080  -0.150 C17 UZO 28 
UZO C18 C19 C 0 1 Y N N N N N 11.208 5.491  10.061 4.497  7.988  -1.179 C18 UZO 29 
UZO C19 C20 C 0 1 Y N N N N N 10.910 4.871  8.868  5.177  7.816  -2.370 C19 UZO 30 
UZO C20 C21 C 0 1 Y N N N N N 11.875 4.126  8.227  6.025  6.736  -2.532 C20 UZO 31 
UZO C21 C22 C 0 1 Y N N N N N 13.140 4.002  8.779  6.196  5.830  -1.502 C21 UZO 32 
UZO C22 C23 C 0 1 N N S N N N 18.202 8.151  15.748 2.538  -1.252 3.133  C22 UZO 33 
UZO C23 C24 C 0 1 N N R N N N 18.530 9.618  15.478 2.353  -2.546 2.309  C23 UZO 34 
UZO C24 C25 C 0 1 N N N N N N 14.014 9.849  10.563 -3.669 -3.209 -1.050 C24 UZO 35 
UZO C25 C26 C 0 1 N N S N N N 15.356 9.792  9.856  -4.341 -2.514 0.135  C25 UZO 36 
UZO C26 C27 C 0 1 N N S N N N 16.895 8.371  8.906  -5.433 -0.514 0.548  C26 UZO 37 
UZO C27 C28 C 0 1 N N R N N N 16.677 9.507  7.888  -6.547 -1.480 0.072  C27 UZO 38 
UZO C28 C29 C 0 1 N N S N N N 15.386 10.182 8.383  -5.843 -2.856 0.161  C28 UZO 39 
UZO C29 C30 C 0 1 Y N N N N N 15.919 6.438  7.581  -5.177 1.323  -1.164 C29 UZO 40 
UZO C30 C31 C 0 1 Y N N N N N 17.545 5.074  7.556  -6.320 2.930  -0.263 C30 UZO 41 
UZO C31 C32 C 0 1 Y N N N N N 18.472 4.030  7.378  -6.994 4.108  0.102  C31 UZO 42 
UZO C32 C33 C 0 1 Y N N N N N 19.948 5.270  8.653  -7.698 3.064  2.037  C32 UZO 43 
UZO C33 C34 C 0 1 Y N N N N N 17.963 6.159  8.310  -6.388 1.830  0.608  C33 UZO 44 
UZO N10 N6  N 0 1 Y N N N N N 16.248 5.263  7.102  -5.571 2.553  -1.327 N10 UZO 45 
UZO N11 N7  N 0 1 N N N N N N 18.220 2.919  6.679  -6.963 5.224  -0.715 N11 UZO 46 
UZO N12 N8  N 0 1 Y N N N N N 19.689 4.166  7.947  -7.662 4.125  1.252  N12 UZO 47 
UZO N13 N9  N 0 1 Y N N N N N 19.154 6.317  8.893  -7.081 1.941  1.736  N13 UZO 48 
UZO N5  N10 N 0 1 Y N N N N N 21.892 10.857 13.286 5.450  -2.841 0.666  N5  UZO 49 
UZO N6  N11 N 0 1 Y N N N N N 19.461 10.667 13.370 3.058  -3.034 -0.009 N6  UZO 50 
UZO N7  N12 N 0 1 N N N N N N 16.179 7.232  12.586 3.763  1.950  1.463  N7  UZO 51 
UZO N8  N13 N 0 1 N N N N N N 15.374 5.783  11.021 4.702  3.939  0.682  N8  UZO 52 
UZO N9  N14 N 0 1 Y N N N N N 16.909 7.040  8.313  -5.655 0.833  0.015  N9  UZO 53 
UZO O2  O6  O 0 1 N N N N N N 19.320 7.461  16.296 1.409  -1.028 3.980  O2  UZO 54 
UZO O6  O7  O 0 1 N N N N N N 15.437 11.596 8.225  -6.186 -3.515 1.381  O6  UZO 55 
UZO H20 H2  H 0 1 N N N N N N 23.832 11.400 12.912 7.488  -2.908 1.000  H20 UZO 56 
UZO H13 H3  H 0 1 N N N N N N 11.337 9.704  11.832 -1.914 -2.044 -3.473 H13 UZO 57 
UZO H12 H4  H 0 1 N N N N N N 11.979 10.071 13.469 -3.454 -1.439 -2.818 H12 UZO 58 
UZO H36 H5  H 0 1 N N N N N N 17.664 11.084 7.274  -8.400 -2.015 0.690  H36 UZO 59 
UZO H18 H6  H 0 1 N N N N N N 22.046 14.660 10.766 5.453  -6.106 -2.672 H18 UZO 60 
UZO H19 H7  H 0 1 N N N N N N 20.643 14.047 10.199 7.087  -6.044 -2.285 H19 UZO 61 
UZO H17 H8  H 0 1 N N N N N N 13.896 11.402 12.623 -1.889 -4.961 -1.640 H17 UZO 62 
UZO H16 H9  H 0 1 N N N N N N 14.221 10.193 13.911 -1.649 -3.706 -2.879 H16 UZO 63 
UZO H33 H10 H 0 1 N N N N N N 19.486 11.123 16.291 1.038  -3.485 3.529  H33 UZO 64 
UZO H14 H11 H 0 1 N N N N N N 13.387 8.004  13.296 -2.350 -0.919 -0.670 H14 UZO 65 
UZO H15 H12 H 0 1 N N N N N N 12.840 7.839  11.593 -0.793 -1.484 -1.323 H15 UZO 66 
UZO H8  H13 H 0 1 N N N N N N 10.573 6.936  14.833 -3.552 0.266  -4.508 H8  UZO 67 
UZO H43 H14 H 0 1 N N N N N N 12.041 6.976  14.119 -2.309 1.332  -4.796 H43 UZO 68 
UZO H11 H16 H 0 1 N N N N N N 10.358 7.655  12.580 -2.368 0.795  -2.452 H11 UZO 69 
UZO H10 H17 H 0 1 N N N N N N 9.892  8.936  13.750 -0.896 0.171  -3.234 H10 UZO 70 
UZO H   H18 H 0 1 N N N N N N 20.332 9.118  14.454 1.350  -1.899 0.485  H   UZO 71 
UZO H1  H19 H 0 1 N N N N N N 18.252 6.593  14.279 1.669  0.320  1.897  H1  UZO 72 
UZO H22 H20 H 0 1 N N N N N N 15.880 6.972  14.632 3.338  1.373  3.434  H22 UZO 73 
UZO H21 H21 H 0 1 N N N N N N 16.047 8.675  14.084 4.635  0.449  2.640  H21 UZO 74 
UZO H26 H22 H 0 1 N N N N N N 15.515 4.094  9.805  6.696  4.585  0.759  H26 UZO 75 
UZO H25 H23 H 0 1 N N N N N N 14.797 3.820  11.429 5.561  5.516  1.765  H25 UZO 76 
UZO H27 H24 H 0 1 N N N N N N 12.695 5.859  11.550 4.133  7.214  0.780  H27 UZO 77 
UZO H28 H25 H 0 1 N N N N N N 10.453 6.075  10.567 3.835  8.831  -1.053 H28 UZO 78 
UZO H29 H26 H 0 1 N N N N N N 9.924  4.968  8.437  5.046  8.524  -3.174 H29 UZO 79 
UZO H30 H27 H 0 1 N N N N N N 11.645 3.637  7.292  6.556  6.601  -3.463 H30 UZO 80 
UZO H31 H28 H 0 1 N N N N N N 13.889 3.414  8.270  6.858  4.987  -1.628 H31 UZO 81 
UZO H2  H29 H 0 1 N N N N N N 17.313 8.069  16.391 3.453  -1.303 3.723  H2  UZO 82 
UZO H3  H30 H 0 1 N N N N N N 17.605 10.184 15.291 3.175  -3.238 2.491  H3  UZO 83 
UZO H35 H31 H 0 1 N N N N N N 13.309 9.177  10.052 -4.058 -2.796 -1.981 H35 UZO 84 
UZO H34 H32 H 0 1 N N N N N N 13.631 10.879 10.525 -3.878 -4.278 -1.011 H34 UZO 85 
UZO H4  H33 H 0 1 N N N N N N 16.062 10.437 10.399 -3.871 -2.831 1.066  H4  UZO 86 
UZO H5  H34 H 0 1 N N N N N N 17.857 8.548  9.409  -5.382 -0.493 1.636  H5  UZO 87 
UZO H6  H35 H 0 1 N N N N N N 16.513 9.082  6.887  -6.842 -1.259 -0.954 H6  UZO 88 
UZO H7  H36 H 0 1 N N N N N N 14.518 9.751  7.863  -6.108 -3.476 -0.696 H7  UZO 89 
UZO H38 H37 H 0 1 N N N N N N 14.953 6.892  7.414  -4.565 0.771  -1.862 H38 UZO 90 
UZO H41 H38 H 0 1 N N N N N N 20.934 5.323  9.090  -8.252 3.121  2.962  H41 UZO 91 
UZO H39 H39 H 0 1 N N N N N N 19.026 2.328  6.690  -6.472 5.200  -1.551 H39 UZO 92 
UZO H40 H40 H 0 1 N N N N N N 17.446 2.436  7.089  -7.432 6.031  -0.452 H40 UZO 93 
UZO H23 H41 H 0 1 N N N N N N 16.267 7.904  11.851 3.174  1.924  0.693  H23 UZO 94 
UZO H24 H42 H 0 1 N N N N N N 15.400 6.550  10.380 4.065  3.953  -0.050 H24 UZO 95 
UZO H32 H43 H 0 1 N N N N N N 19.502 7.793  17.167 1.296  -1.698 4.668  H32 UZO 96 
UZO H37 H44 H 0 1 N N N N N N 14.627 11.980 8.539  -7.130 -3.702 1.476  H37 UZO 97 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
UZO N   C   SING N N 1   
UZO C   C1  SING N N 2   
UZO C1  C2  SING N N 3   
UZO C2  N1  SING N N 4   
UZO N1  C3  SING N N 5   
UZO C3  C4  SING N N 6   
UZO C4  C5  TRIP N N 7   
UZO C5  C6  SING N N 8   
UZO C6  N2  DOUB Y N 9   
UZO N2  C7  SING Y N 10  
UZO C7  C8  DOUB Y N 11  
UZO N3  C8  SING N N 12  
UZO C8  N4  SING Y N 13  
UZO N4  C9  DOUB Y N 14  
UZO C9  N5  SING Y N 15  
UZO N5  C10 DOUB Y N 16  
UZO C7  C10 SING Y N 17  
UZO C10 N6  SING Y N 18  
UZO C6  N6  SING Y N 19  
UZO N6  C11 SING N N 20  
UZO C11 O   SING N N 21  
UZO O   C12 SING N N 22  
UZO C12 C13 SING N N 23  
UZO C13 N7  SING N N 24  
UZO N7  C14 SING N N 25  
UZO C14 O1  DOUB N N 26  
UZO N8  C14 SING N N 27  
UZO C15 N8  SING N N 28  
UZO C16 C15 SING N N 29  
UZO C16 C17 DOUB Y N 30  
UZO C17 C18 SING Y N 31  
UZO C18 C19 DOUB Y N 32  
UZO C19 C20 SING Y N 33  
UZO C20 C21 DOUB Y N 34  
UZO C21 C16 SING Y N 35  
UZO C22 C12 SING N N 36  
UZO O2  C22 SING N N 37  
UZO C23 C22 SING N N 38  
UZO C11 C23 SING N N 39  
UZO O3  C23 SING N N 40  
UZO C24 N1  SING N N 41  
UZO C25 C24 SING N N 42  
UZO C25 O4  SING N N 43  
UZO O4  C26 SING N N 44  
UZO C26 C27 SING N N 45  
UZO O5  C27 SING N N 46  
UZO C27 C28 SING N N 47  
UZO C28 C25 SING N N 48  
UZO O6  C28 SING N N 49  
UZO N9  C26 SING N N 50  
UZO N9  C29 SING Y N 51  
UZO C29 N10 DOUB Y N 52  
UZO N10 C30 SING Y N 53  
UZO C30 C31 DOUB Y N 54  
UZO N11 C31 SING N N 55  
UZO C31 N12 SING Y N 56  
UZO N12 C32 DOUB Y N 57  
UZO C32 N13 SING Y N 58  
UZO N13 C33 DOUB Y N 59  
UZO C33 N9  SING Y N 60  
UZO C30 C33 SING Y N 61  
UZO C9  H20 SING N N 62  
UZO C1  H13 SING N N 63  
UZO C1  H12 SING N N 64  
UZO O5  H36 SING N N 65  
UZO N3  H18 SING N N 66  
UZO N3  H19 SING N N 67  
UZO C3  H17 SING N N 68  
UZO C3  H16 SING N N 69  
UZO O3  H33 SING N N 70  
UZO C2  H14 SING N N 71  
UZO C2  H15 SING N N 72  
UZO N   H8  SING N N 73  
UZO N   H43 SING N N 74  
UZO C   H11 SING N N 75  
UZO C   H10 SING N N 76  
UZO C11 H   SING N N 77  
UZO C12 H1  SING N N 78  
UZO C13 H22 SING N N 79  
UZO C13 H21 SING N N 80  
UZO C15 H26 SING N N 81  
UZO C15 H25 SING N N 82  
UZO C17 H27 SING N N 83  
UZO C18 H28 SING N N 84  
UZO C19 H29 SING N N 85  
UZO C20 H30 SING N N 86  
UZO C21 H31 SING N N 87  
UZO C22 H2  SING N N 88  
UZO C23 H3  SING N N 89  
UZO C24 H35 SING N N 90  
UZO C24 H34 SING N N 91  
UZO C25 H4  SING N N 92  
UZO C26 H5  SING N N 93  
UZO C27 H6  SING N N 94  
UZO C28 H7  SING N N 95  
UZO C29 H38 SING N N 96  
UZO C32 H41 SING N N 97  
UZO N11 H39 SING N N 98  
UZO N11 H40 SING N N 99  
UZO N7  H23 SING N N 100 
UZO N8  H24 SING N N 101 
UZO O2  H32 SING N N 102 
UZO O6  H37 SING N N 103 
# 
loop_
_pdbx_chem_comp_descriptor.comp_id 
_pdbx_chem_comp_descriptor.type 
_pdbx_chem_comp_descriptor.program 
_pdbx_chem_comp_descriptor.program_version 
_pdbx_chem_comp_descriptor.descriptor 
UZO InChI            InChI                1.06  "InChI=1S/C34H42N14O7/c35-9-5-11-46(14-20-25(50)26(51)32(55-20)47-17-44-22-28(36)40-15-42-30(22)47)10-4-8-21-45-23-29(37)41-16-43-31(23)48(21)33-27(52)24(49)19(54-33)13-39-34(53)38-12-18-6-2-1-3-7-18/h1-3,6-7,15-17,19-20,24-27,32-33,49-52H,5,9-14,35H2,(H2,36,40,42)(H2,37,41,43)(H2,38,39,53)/t19-,20+,24-,25-,26-,27-,32+,33+/m1/s1" 
UZO InChIKey         InChI                1.06  GGSIMEWGMXDKIG-CHNVMXDGSA-N                                                                                                                                                                                                                                                                                                                 
UZO SMILES_CANONICAL CACTVS               3.385 "NCCCN(CC#Cc1nc2c(N)ncnc2n1[C@H]3O[C@H](CNC(=O)NCc4ccccc4)[C@@H](O)[C@H]3O)C[C@@H]5O[C@@H]([C@H](O)[C@@H]5O)n6cnc7c(N)ncnc67"                                                                                                                                                                                                               
UZO SMILES           CACTVS               3.385 "NCCCN(CC#Cc1nc2c(N)ncnc2n1[CH]3O[CH](CNC(=O)NCc4ccccc4)[CH](O)[CH]3O)C[CH]5O[CH]([CH](O)[CH]5O)n6cnc7c(N)ncnc67"                                                                                                                                                                                                                           
UZO SMILES_CANONICAL "OpenEye OEToolkits" 2.0.7 "c1ccc(cc1)CNC(=O)NC[C@@H]2[C@H]([C@H]([C@@H](O2)n3c(nc4c3ncnc4N)C#CCN(CCCN)C[C@@H]5[C@H]([C@H]([C@@H](O5)n6cnc7c6ncnc7N)O)O)O)O"                                                                                                                                                                                                           
UZO SMILES           "OpenEye OEToolkits" 2.0.7 "c1ccc(cc1)CNC(=O)NCC2C(C(C(O2)n3c(nc4c3ncnc4N)C#CCN(CCCN)CC5C(C(C(O5)n6cnc7c6ncnc7N)O)O)O)O"                                                                                                                                                                                                                                               
# 
_pdbx_chem_comp_identifier.comp_id           UZO 
_pdbx_chem_comp_identifier.type              "SYSTEMATIC NAME" 
_pdbx_chem_comp_identifier.program           "OpenEye OEToolkits" 
_pdbx_chem_comp_identifier.program_version   2.0.7 
_pdbx_chem_comp_identifier.identifier        "1-[[(2~{R},3~{S},4~{R},5~{R})-5-[8-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]prop-1-ynyl]-6-azanyl-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-3-(phenylmethyl)urea" 
# 
loop_
_pdbx_chem_comp_audit.comp_id 
_pdbx_chem_comp_audit.action_type 
_pdbx_chem_comp_audit.date 
_pdbx_chem_comp_audit.processing_site 
UZO "Create component" 2023-09-07 PDBE 
UZO "Initial release"  2025-03-19 RCSB 
# 
