data_A1CNO
# 
_chem_comp.id                                    A1CNO 
_chem_comp.name                                  "(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-1-(3,5-difluorophenyl)-4-{(2-ethylbutyl)[(1S)-1-hydroxy-2,3-dihydro-1H-indene-5-sulfonyl]amino}-3-hydroxybutan-2-yl]carbamate" 
_chem_comp.type                                  non-polymer 
_chem_comp.pdbx_type                             HETAIN 
_chem_comp.formula                               "C32 H42 F2 N2 O8 S" 
_chem_comp.mon_nstd_parent_comp_id               ? 
_chem_comp.pdbx_synonyms                         ? 
_chem_comp.pdbx_formal_charge                    0 
_chem_comp.pdbx_initial_date                     2025-08-15 
_chem_comp.pdbx_modified_date                    2025-12-19 
_chem_comp.pdbx_ambiguous_flag                   N 
_chem_comp.pdbx_release_status                   REL 
_chem_comp.pdbx_replaced_by                      ? 
_chem_comp.pdbx_replaces                         ? 
_chem_comp.formula_weight                        652.746 
_chem_comp.one_letter_code                       ? 
_chem_comp.three_letter_code                     A1CNO 
_chem_comp.pdbx_model_coordinates_details        ? 
_chem_comp.pdbx_model_coordinates_missing_flag   N 
_chem_comp.pdbx_ideal_coordinates_details        Corina 
_chem_comp.pdbx_ideal_coordinates_missing_flag   N 
_chem_comp.pdbx_model_coordinates_db_code        9Q1P 
_chem_comp.pdbx_subcomponent_list                ? 
_chem_comp.pdbx_processing_site                  RCSB 
_chem_comp.pdbx_pcm                              ? 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.alt_atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.charge 
_chem_comp_atom.pdbx_align 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_leaving_atom_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_n_terminal_atom_flag 
_chem_comp_atom.pdbx_backbone_atom_flag 
_chem_comp_atom.pdbx_c_terminal_atom_flag 
_chem_comp_atom.model_Cartn_x 
_chem_comp_atom.model_Cartn_y 
_chem_comp_atom.model_Cartn_z 
_chem_comp_atom.pdbx_model_Cartn_x_ideal 
_chem_comp_atom.pdbx_model_Cartn_y_ideal 
_chem_comp_atom.pdbx_model_Cartn_z_ideal 
_chem_comp_atom.pdbx_component_atom_id 
_chem_comp_atom.pdbx_component_comp_id 
_chem_comp_atom.pdbx_ordinal 
A1CNO C10 C1  C 0 1 Y N N N N N -18.826 0.326  -1.861  -4.367 1.147  -1.152 C10 A1CNO 1  
A1CNO C13 C2  C 0 1 N N N N N N -18.727 -2.545 -4.755  -2.538 -2.677 0.756  C13 A1CNO 2  
A1CNO C15 C3  C 0 1 N N R N N N -17.494 1.033  -11.887 5.973  -0.430 0.435  C15 A1CNO 3  
A1CNO C17 C4  C 0 1 N N N N N N -17.498 3.763  -11.904 6.995  -1.628 -1.525 C17 A1CNO 4  
A1CNO C20 C5  C 0 1 Y N N N N N -16.920 5.369  -8.266  3.927  3.982  0.692  C20 A1CNO 5  
A1CNO C21 C6  C 0 1 Y N N N N N -16.536 4.294  -7.485  2.731  3.850  1.377  C21 A1CNO 6  
A1CNO C22 C7  C 0 1 Y N N N N N -17.415 3.314  -7.062  1.770  2.960  0.927  C22 A1CNO 7  
A1CNO C24 C8  C 0 1 N N N N N N -19.123 -4.966 -5.430  -3.815 -3.506 2.737  C24 A1CNO 8  
A1CNO C26 C9  C 0 1 N N N N N N -16.752 -4.849 -7.332  -3.560 0.159  1.713  C26 A1CNO 9  
A1CNO C28 C10 C 0 1 N N N N N N -16.714 -2.518 0.551   -8.183 -0.062 0.325  C28 A1CNO 10 
A1CNO C01 C11 C 0 1 N N N N N N -19.940 -0.414 -5.330  -1.267 -0.570 0.138  C01 A1CNO 11 
A1CNO C02 C12 C 0 1 N N S N N N -19.313 0.911  -7.422  1.186  -0.132 -0.045 C02 A1CNO 12 
A1CNO C03 C13 C 0 1 N N N N N N -18.182 0.743  -9.611  3.608  -0.338 0.129  C03 A1CNO 13 
A1CNO C04 C14 C 0 1 N N S N N N -17.246 2.395  -12.565 7.212  -0.505 -0.480 C04 A1CNO 14 
A1CNO C05 C15 C 0 1 N N R N N N -18.416 2.417  -13.609 8.285  -1.157 0.446  C05 A1CNO 15 
A1CNO C06 C16 C 0 1 N N N N N N -19.007 3.670  -11.741 8.394  -2.270 -1.624 C06 A1CNO 16 
A1CNO C07 C17 C 0 1 N N N N N N -19.734 2.335  -6.980  0.959  1.235  -0.694 C07 A1CNO 17 
A1CNO C08 C18 C 0 1 Y N N N N N -19.189 4.472  -8.220  3.199  2.333  -0.889 C08 A1CNO 18 
A1CNO C09 C19 C 0 1 Y N N N N N -19.083 0.137  -0.503  -5.372 2.030  -0.809 C09 A1CNO 19 
A1CNO C11 C20 C 0 1 Y N N N N N -17.839 -0.437 -2.490  -4.575 -0.215 -1.028 C11 A1CNO 20 
A1CNO C12 C21 C 0 1 Y N N N N N -17.096 -1.394 -1.791  -5.784 -0.688 -0.557 C12 A1CNO 21 
A1CNO C14 C22 C 0 1 N N R N N N -20.221 -0.185 -6.829  0.053  -1.080 -0.443 C14 A1CNO 22 
A1CNO C16 C23 C 0 1 N N N N N N -18.097 0.187  -13.008 6.273  -1.413 1.581  C16 A1CNO 23 
A1CNO C18 C24 C 0 1 Y N N N N N -18.759 3.399  -7.429  2.005  2.203  -0.205 C18 A1CNO 24 
A1CNO C19 C25 C 0 1 Y N N N N N -18.262 5.423  -8.614  4.159  3.227  -0.444 C19 A1CNO 25 
A1CNO C23 C26 C 0 1 N N N N N N -18.590 -3.589 -5.886  -3.635 -2.337 1.766  C23 A1CNO 26 
A1CNO C25 C27 C 0 1 N N N N N N -17.130 -3.666 -6.408  -3.239 -1.082 2.547  C25 A1CNO 27 
A1CNO C27 C28 C 0 1 N N N N N N -16.993 -1.735 1.853   -8.652 1.284  0.905  C27 A1CNO 28 
A1CNO C29 C29 C 0 1 Y N N N N N -17.367 -1.576 -0.438  -6.790 0.197  -0.208 C29 A1CNO 29 
A1CNO C30 C30 C 0 1 Y N N N N N -18.350 -0.809 0.205   -6.587 1.558  -0.342 C30 A1CNO 30 
A1CNO C31 C31 C 0 1 N N S N N N -18.437 -1.208 1.667   -7.828 2.306  0.094  C31 A1CNO 31 
A1CNO C32 C32 C 0 1 N N N N N N -18.287 -5.680 -4.353  -4.415 -4.700 1.992  C32 A1CNO 32 
A1CNO F01 F1  F 0 1 N N N N N N -18.676 6.461  -9.377  5.325  3.355  -1.114 F01 A1CNO 33 
A1CNO F02 F2  F 0 1 N N N N N N -15.235 4.190  -7.120  2.501  4.590  2.484  F02 A1CNO 34 
A1CNO N01 N1  N 0 1 N N N N N N -18.658 -1.107 -5.109  -2.330 -1.538 -0.141 N01 A1CNO 35 
A1CNO N02 N2  N 0 1 N N N N N N -19.309 0.840  -8.869  2.466  -0.682 -0.498 N02 A1CNO 36 
A1CNO O01 O1  O 0 1 N N N N N N -17.852 1.208  -4.556  -3.930 -2.598 -1.693 O01 A1CNO 37 
A1CNO O02 O2  O 0 1 N N N N N N -16.209 -0.734 -4.553  -2.505 -0.690 -2.452 O02 A1CNO 38 
A1CNO O03 O3  O 0 1 N N N N N N -21.572 0.208  -7.067  -0.043 -1.135 -1.867 O03 A1CNO 39 
A1CNO O04 O4  O 0 1 N N N N N N -17.065 0.468  -9.236  3.576  0.428  1.072  O04 A1CNO 40 
A1CNO O05 O5  O 0 1 N N N N N N -18.526 1.004  -10.892 4.784  -0.844 -0.288 O05 A1CNO 41 
A1CNO O06 O6  O 0 1 N N N N N N -18.974 1.093  -13.680 7.525  -2.046 1.287  O06 A1CNO 42 
A1CNO O07 O7  O 0 1 N N N N N N -19.368 3.324  -13.103 9.109  -1.940 -0.429 O07 A1CNO 43 
A1CNO O08 O8  O 0 1 N N N N N N -19.495 -2.178 1.744   -8.563 2.736  -1.054 O08 A1CNO 44 
A1CNO S01 S1  S 0 1 N N N N N N -17.522 -0.185 -4.251  -3.298 -1.345 -1.472 S01 A1CNO 45 
A1CNO H12 H1  H 0 1 N N N N N N -19.387 1.058  -2.423  -3.422 1.518  -1.520 H12 A1CNO 46 
A1CNO H15 H2  H 0 1 N N N N N N -19.701 -2.715 -4.273  -1.611 -2.896 1.286  H15 A1CNO 47 
A1CNO H14 H3  H 0 1 N N N N N N -17.921 -2.741 -4.033  -2.837 -3.549 0.174  H14 A1CNO 48 
A1CNO H17 H4  H 0 1 N N N N N N -16.550 0.597  -11.527 5.847  0.580  0.825  H17 A1CNO 49 
A1CNO H20 H5  H 0 1 N N N N N N -16.983 3.855  -10.936 6.262  -2.352 -1.169 H20 A1CNO 50 
A1CNO H21 H6  H 0 1 N N N N N N -17.204 4.598  -12.557 6.689  -1.210 -2.484 H21 A1CNO 51 
A1CNO H22 H7  H 0 1 N N N N N N -16.216 6.123  -8.586  4.676  4.676  1.043  H22 A1CNO 52 
A1CNO H23 H8  H 0 1 N N N N N N -17.066 2.492  -6.455  0.837  2.857  1.461  H23 A1CNO 53 
A1CNO H25 H9  H 0 1 N N N N N N -20.137 -4.821 -5.030  -2.846 -3.786 3.152  H25 A1CNO 54 
A1CNO H26 H10 H 0 1 N N N N N N -19.168 -5.621 -6.313  -4.484 -3.208 3.545  H26 A1CNO 55 
A1CNO H31 H11 H 0 1 N N N N N N -15.693 -4.768 -7.618  -3.123 0.053  0.720  H31 A1CNO 56 
A1CNO H29 H12 H 0 1 N N N N N N -16.916 -5.797 -6.799  -4.641 0.269  1.625  H29 A1CNO 57 
A1CNO H30 H13 H 0 1 N N N N N N -17.379 -4.823 -8.236  -3.144 1.041  2.200  H30 A1CNO 58 
A1CNO H35 H14 H 0 1 N N N N N N -15.636 -2.632 0.362   -8.155 -0.830 1.098  H35 A1CNO 59 
A1CNO H34 H15 H 0 1 N N N N N N -17.193 -3.508 0.555   -8.847 -0.365 -0.485 H34 A1CNO 60 
A1CNO H01 H16 H 0 1 N N N N N N -19.909 0.561  -4.821  -1.165 -0.443 1.216  H01 A1CNO 61 
A1CNO H02 H17 H 0 1 N N N N N N -20.751 -1.024 -4.906  -1.519 0.388  -0.318 H02 A1CNO 62 
A1CNO H03 H18 H 0 1 N N N N N N -18.292 0.736  -7.053  1.202  -0.021 1.040  H03 A1CNO 63 
A1CNO H04 H19 H 0 1 N N N N N N -16.277 2.393  -13.085 7.508  0.456  -0.900 H04 A1CNO 64 
A1CNO H05 H20 H 0 1 N N N N N N -18.027 2.738  -14.587 8.850  -0.421 1.018  H05 A1CNO 65 
A1CNO H06 H21 H 0 1 N N N N N N -19.296 2.885  -11.027 8.299  -3.353 -1.711 H06 A1CNO 66 
A1CNO H07 H22 H 0 1 N N N N N N -19.447 4.629  -11.430 8.922  -1.874 -2.492 H07 A1CNO 67 
A1CNO H08 H23 H 0 1 N N N N N N -20.721 2.559  -7.410  1.031  1.138  -1.777 H08 A1CNO 68 
A1CNO H09 H24 H 0 1 N N N N N N -19.798 2.358  -5.882  -0.031 1.604  -0.427 H09 A1CNO 69 
A1CNO H10 H25 H 0 1 N N N N N N -20.224 4.556  -8.517  3.382  1.741  -1.774 H10 A1CNO 70 
A1CNO H11 H26 H 0 1 N N N N N N -19.844 0.720  -0.006  -5.209 3.094  -0.906 H11 A1CNO 71 
A1CNO H13 H27 H 0 1 N N N N N N -16.333 -1.976 -2.287  -5.945 -1.751 -0.461 H13 A1CNO 72 
A1CNO H16 H28 H 0 1 N N N N N N -20.012 -1.125 -7.362  0.260  -2.077 -0.054 H16 A1CNO 73 
A1CNO H19 H29 H 0 1 N N N N N N -17.314 -0.179 -13.688 6.344  -0.872 2.524  H19 A1CNO 74 
A1CNO H18 H30 H 0 1 N N N N N N -18.655 -0.668 -12.598 5.484  -2.163 1.642  H18 A1CNO 75 
A1CNO H24 H31 H 0 1 N N N N N N -19.220 -3.253 -6.723  -4.572 -2.157 1.239  H24 A1CNO 76 
A1CNO H28 H32 H 0 1 N N N N N N -16.932 -2.739 -6.966  -2.171 -1.110 2.761  H28 A1CNO 77 
A1CNO H27 H33 H 0 1 N N N N N N -16.470 -3.713 -5.529  -3.797 -1.045 3.483  H27 A1CNO 78 
A1CNO H33 H34 H 0 1 N N N N N N -16.927 -2.397 2.729   -9.721 1.423  0.743  H33 A1CNO 79 
A1CNO H32 H35 H 0 1 N N N N N N -16.284 -0.902 1.969   -8.407 1.356  1.964  H32 A1CNO 80 
A1CNO H36 H36 H 0 1 N N N N N N -18.620 -0.334 2.309   -7.566 3.161  0.717  H36 A1CNO 81 
A1CNO H37 H37 H 0 1 N N N N N N -18.754 -6.644 -4.105  -4.649 -5.492 2.704  H37 A1CNO 82 
A1CNO H38 H38 H 0 1 N N N N N N -17.270 -5.853 -4.734  -5.326 -4.389 1.482  H38 A1CNO 83 
A1CNO H39 H39 H 0 1 N N N N N N -18.239 -5.053 -3.451  -3.697 -5.070 1.261  H39 A1CNO 84 
A1CNO H40 H40 H 0 1 N N N N N N -20.188 0.864  -9.346  2.491  -1.294 -1.251 H40 A1CNO 85 
A1CNO H41 H41 H 0 1 N N N N N N -21.705 0.339  -7.999  -0.227 -0.281 -2.283 H41 A1CNO 86 
A1CNO H42 H42 H 0 1 N N N N N N -20.331 -1.746 1.616   -8.094 3.380  -1.603 H42 A1CNO 87 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1CNO C01 C14 SING N N 1  
A1CNO C01 N01 SING N N 2  
A1CNO C02 C07 SING N N 3  
A1CNO C02 C14 SING N N 4  
A1CNO C02 N02 SING N N 5  
A1CNO C03 N02 SING N N 6  
A1CNO C03 O04 DOUB N N 7  
A1CNO C03 O05 SING N N 8  
A1CNO C04 C05 SING N N 9  
A1CNO C04 C15 SING N N 10 
A1CNO C04 C17 SING N N 11 
A1CNO C05 O06 SING N N 12 
A1CNO C05 O07 SING N N 13 
A1CNO C06 C17 SING N N 14 
A1CNO C06 O07 SING N N 15 
A1CNO C07 C18 SING N N 16 
A1CNO C08 C18 DOUB Y N 17 
A1CNO C08 C19 SING Y N 18 
A1CNO C09 C10 DOUB Y N 19 
A1CNO C09 C30 SING Y N 20 
A1CNO C10 C11 SING Y N 21 
A1CNO C11 C12 DOUB Y N 22 
A1CNO C11 S01 SING N N 23 
A1CNO C12 C29 SING Y N 24 
A1CNO C13 C23 SING N N 25 
A1CNO C13 N01 SING N N 26 
A1CNO C14 O03 SING N N 27 
A1CNO C15 C16 SING N N 28 
A1CNO C15 O05 SING N N 29 
A1CNO C16 O06 SING N N 30 
A1CNO C18 C22 SING Y N 31 
A1CNO C19 C20 DOUB Y N 32 
A1CNO C19 F01 SING N N 33 
A1CNO C20 C21 SING Y N 34 
A1CNO C21 C22 DOUB Y N 35 
A1CNO C21 F02 SING N N 36 
A1CNO C23 C24 SING N N 37 
A1CNO C23 C25 SING N N 38 
A1CNO C24 C32 SING N N 39 
A1CNO C25 C26 SING N N 40 
A1CNO C27 C28 SING N N 41 
A1CNO C27 C31 SING N N 42 
A1CNO C28 C29 SING N N 43 
A1CNO C29 C30 DOUB Y N 44 
A1CNO C30 C31 SING N N 45 
A1CNO C31 O08 SING N N 46 
A1CNO N01 S01 SING N N 47 
A1CNO O01 S01 DOUB N N 48 
A1CNO O02 S01 DOUB N N 49 
A1CNO C10 H12 SING N N 50 
A1CNO C13 H15 SING N N 51 
A1CNO C13 H14 SING N N 52 
A1CNO C15 H17 SING N N 53 
A1CNO C17 H20 SING N N 54 
A1CNO C17 H21 SING N N 55 
A1CNO C20 H22 SING N N 56 
A1CNO C22 H23 SING N N 57 
A1CNO C24 H25 SING N N 58 
A1CNO C24 H26 SING N N 59 
A1CNO C26 H31 SING N N 60 
A1CNO C26 H29 SING N N 61 
A1CNO C26 H30 SING N N 62 
A1CNO C28 H35 SING N N 63 
A1CNO C28 H34 SING N N 64 
A1CNO C01 H01 SING N N 65 
A1CNO C01 H02 SING N N 66 
A1CNO C02 H03 SING N N 67 
A1CNO C04 H04 SING N N 68 
A1CNO C05 H05 SING N N 69 
A1CNO C06 H06 SING N N 70 
A1CNO C06 H07 SING N N 71 
A1CNO C07 H08 SING N N 72 
A1CNO C07 H09 SING N N 73 
A1CNO C08 H10 SING N N 74 
A1CNO C09 H11 SING N N 75 
A1CNO C12 H13 SING N N 76 
A1CNO C14 H16 SING N N 77 
A1CNO C16 H19 SING N N 78 
A1CNO C16 H18 SING N N 79 
A1CNO C23 H24 SING N N 80 
A1CNO C25 H28 SING N N 81 
A1CNO C25 H27 SING N N 82 
A1CNO C27 H33 SING N N 83 
A1CNO C27 H32 SING N N 84 
A1CNO C31 H36 SING N N 85 
A1CNO C32 H37 SING N N 86 
A1CNO C32 H38 SING N N 87 
A1CNO C32 H39 SING N N 88 
A1CNO N02 H40 SING N N 89 
A1CNO O03 H41 SING N N 90 
A1CNO O08 H42 SING N N 91 
# 
loop_
_pdbx_chem_comp_descriptor.comp_id 
_pdbx_chem_comp_descriptor.type 
_pdbx_chem_comp_descriptor.program 
_pdbx_chem_comp_descriptor.program_version 
_pdbx_chem_comp_descriptor.descriptor 
A1CNO SMILES           ACDLabs              14.52   "OC1CCc2cc(ccc21)S(=O)(=O)N(CC(CC)CC)CC(O)C(Cc1cc(F)cc(F)c1)NC(=O)OC1COC2OCCC12"                                                                                                                                                                                           
A1CNO InChI            InChI                1.06    "InChI=1S/C32H42F2N2O8S/c1-3-19(4-2)16-36(45(40,41)24-6-7-25-21(14-24)5-8-28(25)37)17-29(38)27(13-20-11-22(33)15-23(34)12-20)35-32(39)44-30-18-43-31-26(30)9-10-42-31/h6-7,11-12,14-15,19,26-31,37-38H,3-5,8-10,13,16-18H2,1-2H3,(H,35,39)/t26-,27-,28-,29+,30-,31+/m0/s1" 
A1CNO InChIKey         InChI                1.06    TUNBVFHGUDWCAR-NZHSYQGNSA-N                                                                                                                                                                                                                                                
A1CNO SMILES_CANONICAL CACTVS               3.385   "CCC(CC)CN(C[C@@H](O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)O[C@H]2CO[C@H]3OCC[C@@H]23)[S](=O)(=O)c4ccc5[C@@H](O)CCc5c4"                                                                                                                                                              
A1CNO SMILES           CACTVS               3.385   "CCC(CC)CN(C[CH](O)[CH](Cc1cc(F)cc(F)c1)NC(=O)O[CH]2CO[CH]3OCC[CH]23)[S](=O)(=O)c4ccc5[CH](O)CCc5c4"                                                                                                                                                                       
A1CNO SMILES_CANONICAL "OpenEye OEToolkits" 3.1.0.0 "CCC(CC)CN(C[C@H]([C@H](Cc1cc(cc(c1)F)F)NC(=O)O[C@H]2CO[C@@H]3[C@H]2CCO3)O)S(=O)(=O)c4ccc5c(c4)CC[C@@H]5O"                                                                                                                                                                 
A1CNO SMILES           "OpenEye OEToolkits" 3.1.0.0 "CCC(CC)CN(CC(C(Cc1cc(cc(c1)F)F)NC(=O)OC2COC3C2CCO3)O)S(=O)(=O)c4ccc5c(c4)CCC5O"                                                                                                                                                                                           
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
A1CNO "SYSTEMATIC NAME" ACDLabs              14.52   "(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-1-(3,5-difluorophenyl)-4-{(2-ethylbutyl)[(1S)-1-hydroxy-2,3-dihydro-1H-indene-5-sulfonyl]amino}-3-hydroxybutan-2-yl]carbamate"                                                                  
A1CNO "SYSTEMATIC NAME" "OpenEye OEToolkits" 3.1.0.0 "[(3~{a}~{S},4~{R},6~{a}~{R})-2,3,3~{a},4,5,6~{a}-hexahydrofuro[2,3-b]furan-4-yl] ~{N}-[(2~{S},3~{R})-1-[3,5-bis(fluoranyl)phenyl]-4-[2-ethylbutyl-[[(1~{S})-1-oxidanyl-2,3-dihydro-1~{H}-inden-5-yl]sulfonyl]amino]-3-oxidanyl-butan-2-yl]carbamate" 
# 
loop_
_pdbx_chem_comp_audit.comp_id 
_pdbx_chem_comp_audit.action_type 
_pdbx_chem_comp_audit.date 
_pdbx_chem_comp_audit.processing_site 
A1CNO "Create component" 2025-08-15 RCSB 
A1CNO "Initial release"  2025-12-24 RCSB 
# 
