data_A1A26
# 
_chem_comp.id                                    A1A26 
_chem_comp.name                                  "(1P)-3-amino-6-[({1-[(2S)-2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperidin-4-yl}amino)methyl]-1-(4-phenyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)thieno[2,3-b]pyrazin-2(1H)-one" 
_chem_comp.type                                  non-polymer 
_chem_comp.pdbx_type                             HETAIN 
_chem_comp.formula                               "C37 H37 F2 N9 O3 S" 
_chem_comp.mon_nstd_parent_comp_id               ? 
_chem_comp.pdbx_synonyms                         ? 
_chem_comp.pdbx_formal_charge                    0 
_chem_comp.pdbx_initial_date                     2024-08-22 
_chem_comp.pdbx_modified_date                    2025-09-05 
_chem_comp.pdbx_ambiguous_flag                   N 
_chem_comp.pdbx_release_status                   REL 
_chem_comp.pdbx_replaced_by                      ? 
_chem_comp.pdbx_replaces                         ? 
_chem_comp.formula_weight                        725.810 
_chem_comp.one_letter_code                       ? 
_chem_comp.three_letter_code                     A1A26 
_chem_comp.pdbx_model_coordinates_details        ? 
_chem_comp.pdbx_model_coordinates_missing_flag   N 
_chem_comp.pdbx_ideal_coordinates_details        Corina 
_chem_comp.pdbx_ideal_coordinates_missing_flag   N 
_chem_comp.pdbx_model_coordinates_db_code        9D9H 
_chem_comp.pdbx_subcomponent_list                ? 
_chem_comp.pdbx_processing_site                  RCSB 
_chem_comp.pdbx_pcm                              ? 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.alt_atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.charge 
_chem_comp_atom.pdbx_align 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_leaving_atom_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_n_terminal_atom_flag 
_chem_comp_atom.pdbx_backbone_atom_flag 
_chem_comp_atom.pdbx_c_terminal_atom_flag 
_chem_comp_atom.model_Cartn_x 
_chem_comp_atom.model_Cartn_y 
_chem_comp_atom.model_Cartn_z 
_chem_comp_atom.pdbx_model_Cartn_x_ideal 
_chem_comp_atom.pdbx_model_Cartn_y_ideal 
_chem_comp_atom.pdbx_model_Cartn_z_ideal 
_chem_comp_atom.pdbx_component_atom_id 
_chem_comp_atom.pdbx_component_comp_id 
_chem_comp_atom.pdbx_ordinal 
A1A26 C13 C1  C 0 1 N N N N N N 1.542  7.981  29.236 -1.581 -2.856 -1.200 C13 A1A26 1  
A1A26 C18 C2  C 0 1 Y N N N N N 4.733  15.562 25.206 -3.368 3.049  3.270  C18 A1A26 2  
A1A26 C17 C3  C 0 1 Y N N N N N 4.849  14.240 24.470 -3.981 3.242  2.047  C17 A1A26 3  
A1A26 C16 C4  C 0 1 Y N N N N N 5.663  13.341 24.900 -3.242 3.129  0.876  C16 A1A26 4  
A1A26 C15 C5  C 0 1 N N N N N N 7.195  10.539 23.274 -4.834 5.028  -1.789 C15 A1A26 5  
A1A26 C19 C6  C 0 1 Y N N N N N 5.484  15.793 26.213 -2.020 2.744  3.329  C19 A1A26 6  
A1A26 C20 C7  C 0 1 Y N N N N N 6.466  14.748 26.681 -1.283 2.625  2.164  C20 A1A26 7  
A1A26 C11 C8  C 0 1 N N N N N N 0.245  11.351 24.296 -7.240 -1.269 0.506  C11 A1A26 8  
A1A26 C12 C9  C 0 1 N N N N N N -1.087 11.426 24.843 -7.374 -2.588 1.129  C12 A1A26 9  
A1A26 C1  C10 C 0 1 Y N N N N N 1.636  9.276  26.984 -3.790 -1.747 -0.744 C1  A1A26 10 
A1A26 C2  C11 C 0 1 Y N N N N N 1.006  8.834  28.126 -2.978 -2.791 -0.638 C2  A1A26 11 
A1A26 C3  C12 C 0 1 Y N N N N N -0.502 10.232 26.567 -5.223 -3.123 0.451  C3  A1A26 12 
A1A26 C4  C13 C 0 1 Y N N N N N 0.851  10.051 26.141 -5.047 -1.889 -0.153 C4  A1A26 13 
A1A26 C5  C14 C 0 1 Y N N N N N 2.474  10.514 24.426 -5.929 0.295  -0.719 C5  A1A26 14 
A1A26 C6  C15 C 0 1 Y N N N N N 3.398  11.418 24.653 -4.973 1.183  -0.242 C6  A1A26 15 
A1A26 C7  C16 C 0 1 Y N N N N N 4.744  11.201 24.036 -4.822 2.421  -0.843 C7  A1A26 16 
A1A26 C8  C17 C 0 1 Y N N N N N 4.972  10.111 23.267 -5.624 2.778  -1.925 C8  A1A26 17 
A1A26 C9  C18 C 0 1 Y N N N N N 3.905  9.098  23.001 -6.577 1.888  -2.396 C9  A1A26 18 
A1A26 C10 C19 C 0 1 Y N N N N N 2.693  9.268  23.574 -6.729 0.652  -1.796 C10 A1A26 19 
A1A26 C14 C20 C 0 1 N N N N N N 7.050  11.948 23.575 -3.523 4.481  -1.208 C14 A1A26 20 
A1A26 C21 C21 C 0 1 Y N N N N N 6.576  13.609 26.059 -1.889 2.822  0.939  C21 A1A26 21 
A1A26 C22 C22 C 0 1 N N N N N N 2.261  5.814  28.486 0.749  -2.415 -0.709 C22 A1A26 22 
A1A26 C23 C23 C 0 1 N N N N N N 2.829  6.210  27.154 1.730  -2.513 0.463  C23 A1A26 23 
A1A26 C24 C24 C 0 1 N N N N N N 3.994  5.295  26.897 3.162  -2.502 -0.075 C24 A1A26 24 
A1A26 C25 C25 C 0 1 N N N N N N 2.768  3.428  27.680 2.495  -1.170 -1.987 C25 A1A26 25 
A1A26 C26 C26 C 0 1 N N N N N N 1.772  4.375  28.384 1.042  -1.142 -1.507 C26 A1A26 26 
A1A26 C27 C27 C 0 1 N N N N N N 4.520  3.166  26.040 4.799  -1.153 -1.242 C27 A1A26 27 
A1A26 C28 C28 C 0 1 N N S N N N 4.882  3.381  24.559 5.650  -0.720 -0.047 C28 A1A26 28 
A1A26 C29 C29 C 0 1 N N N N N N 5.780  2.163  24.245 5.051  0.543  0.575  C29 A1A26 29 
A1A26 C30 C30 C 0 1 Y N N N N N 5.736  4.614  24.255 7.056  -0.434 -0.509 C30 A1A26 30 
A1A26 C31 C31 C 0 1 Y N N N N N 7.800  2.250  22.723 6.426  2.146  1.937  C31 A1A26 31 
A1A26 C32 C32 C 0 1 Y N N N N N 6.818  2.064  20.757 6.915  0.899  3.633  C32 A1A26 32 
A1A26 C33 C33 C 0 1 Y N N N N N 6.891  4.957  25.217 7.287  0.548  -1.457 C33 A1A26 33 
A1A26 C34 C34 C 0 1 Y N N N N N 7.680  5.984  25.002 8.578  0.810  -1.881 C34 A1A26 34 
A1A26 C35 C35 C 0 1 Y N N N N N 7.425  6.799  23.779 9.637  0.090  -1.356 C35 A1A26 35 
A1A26 C36 C36 C 0 1 Y N N N N N 6.449  6.510  22.900 9.404  -0.892 -0.408 C36 A1A26 36 
A1A26 C37 C37 C 0 1 Y N N N N N 5.530  5.316  23.149 8.115  -1.149 0.019  C37 A1A26 37 
A1A26 F1  F1  F 0 1 N N N N N N 7.118  4.212  26.344 6.252  1.249  -1.969 F1  A1A26 38 
A1A26 F2  F2  F 0 1 N N N N N N 8.271  7.825  23.615 10.898 0.344  -1.769 F2  A1A26 39 
A1A26 N1  N1  N 0 1 N N N N N N 1.161  10.653 24.942 -6.086 -0.958 -0.114 N1  A1A26 40 
A1A26 N2  N2  N 0 1 N N N N N N -2.044 12.106 24.122 -8.553 -2.940 1.776  N2  A1A26 41 
A1A26 N3  N3  N 0 1 N N N N N N -1.481 10.914 25.962 -6.374 -3.434 1.070  N3  A1A26 42 
A1A26 N4  N4  N 0 1 N N N N N N 5.796  12.143 24.192 -3.859 3.323  -0.362 N4  A1A26 43 
A1A26 N5  N5  N 0 1 N N N N N N 1.145  6.657  28.877 -0.627 -2.367 -0.196 N5  A1A26 44 
A1A26 N6  N6  N 0 1 N N N N N N 3.438  4.017  26.518 3.394  -1.263 -0.828 N6  A1A26 45 
A1A26 N7  N7  N 0 1 Y N N N N N 6.437  2.178  22.946 5.855  0.946  1.732  N7  A1A26 46 
A1A26 N8  N8  N 0 1 Y N N N N N 8.015  2.206  21.450 7.059  2.104  3.082  N8  A1A26 47 
A1A26 N9  N9  N 0 1 Y N N N N N 5.781  2.054  21.682 6.182  0.157  2.846  N9  A1A26 48 
A1A26 O1  O1  O 0 1 N N N N N N 0.557  11.919 23.126 -8.159 -0.469 0.544  O1  A1A26 49 
A1A26 O2  O2  O 0 1 N N N N N N 6.246  9.827  22.622 -5.479 3.988  -2.529 O2  A1A26 50 
A1A26 O3  O3  O 0 1 N N N N N N 3.666  3.519  23.820 5.672  -1.766 0.926  O3  A1A26 51 
A1A26 S1  S1  S 0 1 Y N N N N N -0.673 9.405  28.113 -3.762 -4.088 0.249  S1  A1A26 52 
A1A26 H7  H1  H 0 1 N N N N N N 2.638  8.058  29.294 -1.340 -3.887 -1.458 H7  A1A26 53 
A1A26 H8  H2  H 0 1 N N N N N N 1.102  8.273  30.201 -1.519 -2.233 -2.092 H8  A1A26 54 
A1A26 H14 H3  H 0 1 N N N N N N 4.019  16.304 24.880 -3.940 3.142  4.181  H14 A1A26 55 
A1A26 H13 H4  H 0 1 N N N N N N 4.251  14.055 23.590 -5.033 3.480  2.002  H13 A1A26 56 
A1A26 H12 H5  H 0 1 N N N N N N 7.343  10.035 24.241 -5.484 5.357  -0.979 H12 A1A26 57 
A1A26 H11 H6  H 0 1 N N N N N N 8.110  10.450 22.671 -4.619 5.869  -2.449 H11 A1A26 58 
A1A26 H15 H7  H 0 1 N N N N N N 5.416  16.738 26.730 -1.542 2.598  4.286  H15 A1A26 59 
A1A26 H16 H8  H 0 1 N N N N N N 7.086  14.947 27.543 -0.231 2.387  2.214  H16 A1A26 60 
A1A26 H1  H9  H 0 1 N N N N N N 2.665  9.037  26.761 -3.496 -0.842 -1.257 H1  A1A26 61 
A1A26 H2  H10 H 0 1 N N N N N N 3.195  12.286 25.262 -4.350 0.909  0.597  H2  A1A26 62 
A1A26 H3  H11 H 0 1 N N N N N N 4.099  8.248  22.364 -7.202 2.161  -3.234 H3  A1A26 63 
A1A26 H4  H12 H 0 1 N N N N N N 1.904  8.544  23.433 -7.473 -0.038 -2.166 H4  A1A26 64 
A1A26 H10 H13 H 0 1 N N N N N N 7.853  12.267 24.256 -2.862 4.169  -2.016 H10 A1A26 65 
A1A26 H9  H14 H 0 1 N N N N N N 7.102  12.534 22.646 -3.036 5.249  -0.607 H9  A1A26 66 
A1A26 H17 H15 H 0 1 N N N N N N 7.306  12.876 26.370 -1.312 2.733  0.030  H17 A1A26 67 
A1A26 H18 H16 H 0 1 N N N N N N 3.054  5.867  29.247 0.866  -3.285 -1.356 H18 A1A26 68 
A1A26 H20 H17 H 0 1 N N N N N N 3.167  7.257  27.181 1.585  -1.664 1.130  H20 A1A26 69 
A1A26 H19 H18 H 0 1 N N N N N N 2.070  6.090  26.367 1.553  -3.440 1.009  H19 A1A26 70 
A1A26 H22 H19 H 0 1 N N N N N N 4.602  5.190  27.808 3.863  -2.557 0.758  H22 A1A26 71 
A1A26 H21 H20 H 0 1 N N N N N N 4.618  5.694  26.084 3.310  -3.359 -0.732 H21 A1A26 72 
A1A26 H23 H21 H 0 1 N N N N N N 2.218  2.536  27.346 2.647  -2.034 -2.634 H23 A1A26 73 
A1A26 H24 H22 H 0 1 N N N N N N 3.537  3.133  28.409 2.711  -0.258 -2.543 H24 A1A26 74 
A1A26 H26 H23 H 0 1 N N N N N N 0.828  4.368  27.819 0.375  -1.089 -2.367 H26 A1A26 75 
A1A26 H25 H24 H 0 1 N N N N N N 1.593  3.996  29.401 0.886  -0.271 -0.870 H25 A1A26 76 
A1A26 H28 H25 H 0 1 N N N N N N 4.218  2.117  26.173 4.887  -0.413 -2.038 H28 A1A26 77 
A1A26 H27 H26 H 0 1 N N N N N N 5.414  3.370  26.647 5.147  -2.120 -1.605 H27 A1A26 78 
A1A26 H30 H27 H 0 1 N N N N N N 5.154  1.260  24.296 5.048  1.345  -0.163 H30 A1A26 79 
A1A26 H29 H28 H 0 1 N N N N N N 6.561  2.112  25.018 4.029  0.341  0.896  H29 A1A26 80 
A1A26 H32 H29 H 0 1 N N N N N N 8.559  2.330  23.487 6.374  2.995  1.272  H32 A1A26 81 
A1A26 H33 H30 H 0 1 N N N N N N 6.712  1.977  19.686 7.334  0.588  4.579  H33 A1A26 82 
A1A26 H34 H31 H 0 1 N N N N N N 8.481  6.229  25.683 8.759  1.575  -2.621 H34 A1A26 83 
A1A26 H35 H32 H 0 1 N N N N N N 6.315  7.121  22.020 10.231 -1.451 0.005  H35 A1A26 84 
A1A26 H36 H33 H 0 1 N N N N N N 4.746  5.055  22.454 7.934  -1.915 0.759  H36 A1A26 85 
A1A26 H5  H34 H 0 1 N N N N N N -2.977 12.179 24.474 -9.291 -2.311 1.817  H5  A1A26 86 
A1A26 H6  H35 H 0 1 N N N N N N -1.805 12.527 23.247 -8.638 -3.815 2.188  H6  A1A26 87 
A1A26 H39 H36 H 0 1 N N N N N N 0.505  6.713  28.111 -0.710 -2.887 0.665  H39 A1A26 88 
A1A26 H31 H39 H 0 1 N N N N N N 3.209  4.301  24.105 6.040  -2.599 0.601  H31 A1A26 89 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1A26 C32 N8  SING Y N 1  
A1A26 C32 N9  DOUB Y N 2  
A1A26 N8  C31 DOUB Y N 3  
A1A26 N9  N7  SING Y N 4  
A1A26 O2  C8  SING N N 5  
A1A26 O2  C15 SING N N 6  
A1A26 C31 N7  SING Y N 7  
A1A26 C36 C37 DOUB Y N 8  
A1A26 C36 C35 SING Y N 9  
A1A26 N7  C29 SING N N 10 
A1A26 C9  C8  DOUB Y N 11 
A1A26 C9  C10 SING Y N 12 
A1A26 O1  C11 DOUB N N 13 
A1A26 C37 C30 SING Y N 14 
A1A26 C8  C7  SING Y N 15 
A1A26 C15 C14 SING N N 16 
A1A26 C10 C5  DOUB Y N 17 
A1A26 C14 N4  SING N N 18 
A1A26 F2  C35 SING N N 19 
A1A26 C35 C34 DOUB Y N 20 
A1A26 O3  C28 SING N N 21 
A1A26 C7  N4  SING N N 22 
A1A26 C7  C6  DOUB Y N 23 
A1A26 N2  C12 SING N N 24 
A1A26 N4  C16 SING N N 25 
A1A26 C29 C28 SING N N 26 
A1A26 C30 C28 SING N N 27 
A1A26 C30 C33 DOUB Y N 28 
A1A26 C11 C12 SING N N 29 
A1A26 C11 N1  SING N N 30 
A1A26 C5  C6  SING Y N 31 
A1A26 C5  N1  SING N N 32 
A1A26 C17 C16 DOUB Y N 33 
A1A26 C17 C18 SING Y N 34 
A1A26 C28 C27 SING N N 35 
A1A26 C12 N3  DOUB N N 36 
A1A26 C16 C21 SING Y N 37 
A1A26 N1  C4  SING N N 38 
A1A26 C34 C33 SING Y N 39 
A1A26 C18 C19 DOUB Y N 40 
A1A26 C33 F1  SING N N 41 
A1A26 N3  C3  SING N N 42 
A1A26 C27 N6  SING N N 43 
A1A26 C21 C20 DOUB Y N 44 
A1A26 C4  C3  DOUB Y N 45 
A1A26 C4  C1  SING Y N 46 
A1A26 C19 C20 SING Y N 47 
A1A26 N6  C24 SING N N 48 
A1A26 N6  C25 SING N N 49 
A1A26 C3  S1  SING Y N 50 
A1A26 C24 C23 SING N N 51 
A1A26 C1  C2  DOUB Y N 52 
A1A26 C23 C22 SING N N 53 
A1A26 C25 C26 SING N N 54 
A1A26 S1  C2  SING Y N 55 
A1A26 C2  C13 SING N N 56 
A1A26 C26 C22 SING N N 57 
A1A26 C22 N5  SING N N 58 
A1A26 N5  C13 SING N N 59 
A1A26 C13 H7  SING N N 60 
A1A26 C13 H8  SING N N 61 
A1A26 C18 H14 SING N N 62 
A1A26 C17 H13 SING N N 63 
A1A26 C15 H12 SING N N 64 
A1A26 C15 H11 SING N N 65 
A1A26 C19 H15 SING N N 66 
A1A26 C20 H16 SING N N 67 
A1A26 C1  H1  SING N N 68 
A1A26 C6  H2  SING N N 69 
A1A26 C9  H3  SING N N 70 
A1A26 C10 H4  SING N N 71 
A1A26 C14 H10 SING N N 72 
A1A26 C14 H9  SING N N 73 
A1A26 C21 H17 SING N N 74 
A1A26 C22 H18 SING N N 75 
A1A26 C23 H20 SING N N 76 
A1A26 C23 H19 SING N N 77 
A1A26 C24 H22 SING N N 78 
A1A26 C24 H21 SING N N 79 
A1A26 C25 H23 SING N N 80 
A1A26 C25 H24 SING N N 81 
A1A26 C26 H26 SING N N 82 
A1A26 C26 H25 SING N N 83 
A1A26 C27 H28 SING N N 84 
A1A26 C27 H27 SING N N 85 
A1A26 C29 H30 SING N N 86 
A1A26 C29 H29 SING N N 87 
A1A26 C31 H32 SING N N 88 
A1A26 C32 H33 SING N N 89 
A1A26 C34 H34 SING N N 90 
A1A26 C36 H35 SING N N 91 
A1A26 C37 H36 SING N N 92 
A1A26 N2  H5  SING N N 93 
A1A26 N2  H6  SING N N 94 
A1A26 N5  H39 SING N N 95 
A1A26 O3  H31 SING N N 96 
# 
loop_
_pdbx_chem_comp_descriptor.comp_id 
_pdbx_chem_comp_descriptor.type 
_pdbx_chem_comp_descriptor.program 
_pdbx_chem_comp_descriptor.program_version 
_pdbx_chem_comp_descriptor.descriptor 
A1A26 SMILES           ACDLabs              14.52 "Fc1ccc(c(F)c1)C(O)(Cn1cncn1)CN1CCC(CC1)NCc1cc2N(C(=O)C(N)=Nc2s1)c1ccc2OCCN(c3ccccc3)c2c1"                                                                                                                                                                          
A1A26 InChI            InChI                1.06  "InChI=1S/C37H37F2N9O3S/c38-24-6-8-29(30(39)16-24)37(50,21-46-23-41-22-43-46)20-45-12-10-25(11-13-45)42-19-28-18-32-35(52-28)44-34(40)36(49)48(32)27-7-9-33-31(17-27)47(14-15-51-33)26-4-2-1-3-5-26/h1-9,16-18,22-23,25,42,50H,10-15,19-21H2,(H2,40,44)/t37-/m0/s1" 
A1A26 InChIKey         InChI                1.06  PRCZCNBGHGABSD-QNGWXLTQSA-N                                                                                                                                                                                                                                         
A1A26 SMILES_CANONICAL CACTVS               3.385 "NC1=Nc2sc(CNC3CCN(CC3)C[C@](O)(Cn4cncn4)c5ccc(F)cc5F)cc2N(C1=O)c6ccc7OCCN(c8ccccc8)c7c6"                                                                                                                                                                           
A1A26 SMILES           CACTVS               3.385 "NC1=Nc2sc(CNC3CCN(CC3)C[C](O)(Cn4cncn4)c5ccc(F)cc5F)cc2N(C1=O)c6ccc7OCCN(c8ccccc8)c7c6"                                                                                                                                                                            
A1A26 SMILES_CANONICAL "OpenEye OEToolkits" 2.0.7 "c1ccc(cc1)N2CCOc3c2cc(cc3)N4c5cc(sc5N=C(C4=O)N)CNC6CCN(CC6)C[C@](Cn7cncn7)(c8ccc(cc8F)F)O"                                                                                                                                                                         
A1A26 SMILES           "OpenEye OEToolkits" 2.0.7 "c1ccc(cc1)N2CCOc3c2cc(cc3)N4c5cc(sc5N=C(C4=O)N)CNC6CCN(CC6)CC(Cn7cncn7)(c8ccc(cc8F)F)O"                                                                                                                                                                            
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
A1A26 "SYSTEMATIC NAME" ACDLabs              14.52 "(1P)-3-amino-6-[({1-[(2S)-2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperidin-4-yl}amino)methyl]-1-(4-phenyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)thieno[2,3-b]pyrazin-2(1H)-one" 
A1A26 "SYSTEMATIC NAME" "OpenEye OEToolkits" 2.0.7 "3-azanyl-6-[[[1-[(2~{S})-2-[2,4-bis(fluoranyl)phenyl]-2-oxidanyl-3-(1,2,4-triazol-1-yl)propyl]piperidin-4-yl]amino]methyl]-1-(4-phenyl-2,3-dihydro-1,4-benzoxazin-6-yl)thieno[2,3-b]pyrazin-2-one"     
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_pdbx_chem_comp_audit.comp_id 
_pdbx_chem_comp_audit.action_type 
_pdbx_chem_comp_audit.date 
_pdbx_chem_comp_audit.processing_site 
A1A26 "Create component" 2024-08-22 RCSB 
A1A26 "Initial release"  2025-09-10 RCSB 
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