data_PRD_002597
# 
_pdbx_reference_molecule.prd_id                       PRD_002597 
_pdbx_reference_molecule.name                         "Microcolin H" 
_pdbx_reference_molecule.represent_as                 polymer 
_pdbx_reference_molecule.type                         Lipopeptide 
_pdbx_reference_molecule.type_evidence_code           ? 
_pdbx_reference_molecule.class                        Antitumor 
_pdbx_reference_molecule.class_evidence_code          ? 
_pdbx_reference_molecule.formula                      "C38 H65 N5 O9" 
_pdbx_reference_molecule.formula_weight               735.951 
_pdbx_reference_molecule.chem_comp_id                 ? 
_pdbx_reference_molecule.release_status               REL 
_pdbx_reference_molecule.replaces                     ? 
_pdbx_reference_molecule.replaced_by                  ? 
_pdbx_reference_molecule.compound_details             "Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPalpha/beta. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models." 
_pdbx_reference_molecule.description                  "Modified polypeptide capped either side by variable UNK residues. UNK -methylated Leucine - Acetylated Threonine - Methylated Valine - Hydroxylated proline - UNK " 
_pdbx_reference_molecule.representative_PDB_id_code   pdb_00009ta5 
# 
_pdbx_reference_entity_list.prd_id          PRD_002597 
_pdbx_reference_entity_list.ref_entity_id   1 
_pdbx_reference_entity_list.component_id    1 
_pdbx_reference_entity_list.type            polymer 
_pdbx_reference_entity_list.details         . 
# 
loop_
_pdbx_reference_entity_poly_link.prd_id 
_pdbx_reference_entity_poly_link.ref_entity_id 
_pdbx_reference_entity_poly_link.link_id 
_pdbx_reference_entity_poly_link.atom_id_1 
_pdbx_reference_entity_poly_link.comp_id_1 
_pdbx_reference_entity_poly_link.entity_seq_num_1 
_pdbx_reference_entity_poly_link.atom_id_2 
_pdbx_reference_entity_poly_link.comp_id_2 
_pdbx_reference_entity_poly_link.entity_seq_num_2 
_pdbx_reference_entity_poly_link.value_order 
_pdbx_reference_entity_poly_link.component_id 
_pdbx_reference_entity_poly_link.details 
_pdbx_reference_entity_poly_link.insert_code_1 
_pdbx_reference_entity_poly_link.insert_code_2 
PRD_002597 1 1 C C9T 1 N  MLE   2 sing 1 . . . 
PRD_002597 1 2 C MLE 2 N  TH5   3 sing 1 . . . 
PRD_002597 1 3 C TH5 3 N  MVA   4 sing 1 . . . 
PRD_002597 1 4 C MVA 4 N  HZP   5 sing 1 . . . 
PRD_002597 1 5 C HZP 5 N7 A1IG7 6 sing 1 . . . 
# 
_pdbx_reference_entity_poly.prd_id          PRD_002597 
_pdbx_reference_entity_poly.ref_entity_id   1 
_pdbx_reference_entity_poly.db_code         . 
_pdbx_reference_entity_poly.db_name         . 
_pdbx_reference_entity_poly.type            peptide-like 
# 
_pdbx_reference_entity_sequence.prd_id          PRD_002597 
_pdbx_reference_entity_sequence.ref_entity_id   1 
_pdbx_reference_entity_sequence.type            peptide-like 
_pdbx_reference_entity_sequence.NRP_flag        N 
# 
loop_
_pdbx_reference_entity_poly_seq.prd_id 
_pdbx_reference_entity_poly_seq.ref_entity_id 
_pdbx_reference_entity_poly_seq.num 
_pdbx_reference_entity_poly_seq.mon_id 
_pdbx_reference_entity_poly_seq.parent_mon_id 
_pdbx_reference_entity_poly_seq.hetero 
_pdbx_reference_entity_poly_seq.observed 
PRD_002597 1 1 C9T   .   N Y 
PRD_002597 1 2 MLE   LEU N Y 
PRD_002597 1 3 TH5   THR N Y 
PRD_002597 1 4 MVA   VAL N Y 
PRD_002597 1 5 HZP   PRO N Y 
PRD_002597 1 6 A1IG7 .   N Y 
# 
loop_
_pdbx_prd_audit.prd_id 
_pdbx_prd_audit.date 
_pdbx_prd_audit.processing_site 
_pdbx_prd_audit.action_type 
PRD_002597 2025-11-27 PDBE "Create molecule" 
PRD_002597 2026-02-04 RCSB "Initial release" 
# 
_pdbx_reference_entity_src_nat.db_code               ? 
_pdbx_reference_entity_src_nat.db_name               ? 
_pdbx_reference_entity_src_nat.ordinal               1 
_pdbx_reference_entity_src_nat.organism_scientific   "Moorena producens" 
_pdbx_reference_entity_src_nat.prd_id                PRD_002597 
_pdbx_reference_entity_src_nat.ref_entity_id         1 
_pdbx_reference_entity_src_nat.source                ? 
_pdbx_reference_entity_src_nat.strain                ? 
_pdbx_reference_entity_src_nat.taxid                 1155739 
# 
