data_8FD5
# 
_entry.id   8FD5 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8FD5         pdb_00008fd5 10.2210/pdb8fd5/pdb 
WWPDB D_1000270416 ?            ?                   
EMDB  EMD-29002    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1  'Structure model' 1 0 2023-01-11 ? 
2  'EM metadata'     1 0 2023-01-11 ? 
3  FSC               1 0 2023-01-11 ? 
4  'Half map'        1 0 2023-01-11 1 
5  'Half map'        1 0 2023-01-11 2 
6  Image             1 0 2023-01-11 ? 
7  'Primary map'     1 0 2023-01-11 ? 
8  'Structure model' 1 1 2023-10-11 ? 
9  FSC               1 0 2023-01-11 ? 
10 'Half map'        1 0 2023-01-11 1 
11 'Half map'        1 0 2023-01-11 2 
12 Image             1 0 2023-01-11 ? 
13 'Primary map'     1 0 2023-01-11 ? 
14 'Structure model' 1 2 2025-03-05 ? 
15 'EM metadata'     2 0 2025-03-05 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1  1  'Structure model' repository 'Initial release' ? ? 
2  2  'EM metadata'     repository 'Initial release' ? ? 
3  3  FSC               repository 'Initial release' ? ? 
4  4  'Half map'        repository 'Initial release' ? ? 
5  5  'Half map'        repository 'Initial release' ? ? 
6  6  Image             repository 'Initial release' ? ? 
7  7  'Primary map'     repository 'Initial release' ? ? 
8  9  FSC               repository 'Initial release' ? ? 
9  10 'Half map'        repository 'Initial release' ? ? 
10 11 'Half map'        repository 'Initial release' ? ? 
11 12 Image             repository 'Initial release' ? ? 
12 13 'Primary map'     repository 'Initial release' ? ? 
13 14 'Structure model' repository Obsolete          ? ? 
14 15 'EM metadata'     repository Obsolete          ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1  8  'Structure model' 'Data collection'      
2  8  'Structure model' 'Database references'  
3  14 'Structure model' Advisory               
4  14 'Structure model' 'Data collection'      
5  14 'Structure model' 'Database references'  
6  14 'Structure model' Other                  
7  14 'Structure model' 'Structure summary'    
8  15 'EM metadata'     Advisory               
9  15 'EM metadata'     'Database references'  
10 15 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1  8  'Structure model' chem_comp_atom            
2  8  'Structure model' chem_comp_bond            
3  8  'Structure model' citation                  
4  8  'Structure model' citation_author           
5  14 'Structure model' citation                  
6  14 'Structure model' citation_author           
7  14 'Structure model' em_admin                  
8  14 'Structure model' pdbx_database_PDB_obs_spr 
9  14 'Structure model' pdbx_database_status      
10 14 'Structure model' pdbx_entry_details        
11 15 'EM metadata'     citation                  
12 15 'EM metadata'     citation_author           
13 15 'EM metadata'     em_admin                  
14 15 'EM metadata'     pdbx_database_PDB_obs_spr 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  8  'Structure model' '_citation.journal_volume'          
2  8  'Structure model' '_citation.page_first'              
3  8  'Structure model' '_citation.page_last'               
4  8  'Structure model' '_citation.pdbx_database_id_PubMed' 
5  8  'Structure model' '_citation.title'                   
6  8  'Structure model' '_citation.year'                    
7  14 'Structure model' '_em_admin.current_status'          
8  14 'Structure model' '_em_admin.last_update'             
9  14 'Structure model' '_pdbx_database_status.status_code' 
10 15 'EM metadata'     '_em_admin.current_status'          
11 15 'EM metadata'     '_em_admin.last_update'             
# 
_pdbx_database_PDB_obs_spr.id               OBSLTE 
_pdbx_database_PDB_obs_spr.date             2025-03-05 
_pdbx_database_PDB_obs_spr.pdb_id           NONE 
_pdbx_database_PDB_obs_spr.replace_pdb_id   8FD5 
_pdbx_database_PDB_obs_spr.details          'This entry has been made obsolete due to paper retraction' 
# 
_pdbx_database_status.status_code                     OBS 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8FD5 
_pdbx_database_status.recvd_initial_deposition_date   2022-12-02 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Nucleocapsid monomer structure from SARS-CoV-2' 
_pdbx_database_related.db_id          EMD-29002 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              debkelly@psu.edu 
_pdbx_contact_author.name_first         Deb 
_pdbx_contact_author.name_last          Kelly 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7341-7435 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Casasanta, M.' 1 0000-0001-6614-9623 
'Jonaid, G.M.'  2 0000-0002-5694-2262 
'Kaylor, L.'    3 ?                   
'Luqiu, W.'     4 ?                   
'DiCecco, L.'   5 0000-0001-8420-1114 
'Solares, M.'   6 0000-0001-8388-7011 
'Berry, S.'     7 0000-0002-9537-312X 
'Kelly, D.F.'   8 0000-0002-7341-7435 
# 
loop_
_citation.abstract 
_citation.abstract_id_CAS 
_citation.book_id_ISBN 
_citation.book_publisher 
_citation.book_publisher_city 
_citation.book_title 
_citation.coordinate_linkage 
_citation.country 
_citation.database_id_Medline 
_citation.details 
_citation.id 
_citation.journal_abbrev 
_citation.journal_id_ASTM 
_citation.journal_id_CSD 
_citation.journal_id_ISSN 
_citation.journal_full 
_citation.journal_issue 
_citation.journal_volume 
_citation.language 
_citation.page_first 
_citation.page_last 
_citation.title 
_citation.year 
_citation.database_id_CSD 
_citation.pdbx_database_id_DOI 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_patent 
_citation.unpublished_flag 
? ? ? ? ? ? ? US ? ? primary 'Microsc Microanal' ? ? 1435-8115 ? ? ?  ? ?    ?    
;Retraction of: Structural Insights of the SARS-CoV-2 Nucleocapsid Protein: Implications for the Inner-workings of Rapid Antigen Tests.
;
2025 ? 10.1093/mam/ozae127        39837351 ? ? 
? ? ? ? ? ? ? US ? ? 1       'Microsc Microanal' ? ? 1435-8115 ? ? 29 ? 649  657  
'Structural Insights of the SARS-CoV-2 Nucleocapsid Protein: Implications for the Inner-workings of Rapid Antigen Tests.' 2023 ? 
10.1093/micmic/ozac036     37749713 ? ? 
? ? ? ? ? ? ? UK ? ? 2       Nanoscale           ? ? 2040-3372 ? ? 13 ? 7285 7293 
'Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy.' 2021 ? 
10.1016/j.apsb.2020.04.009 33889923 ? ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Casasanta, M.A.' 1  ? 
primary 'Jonaid, G.M.'    2  ? 
primary 'Kaylor, L.'      3  ? 
primary 'Luqiu, W.Y.'     4  ? 
primary 'DiCecco, L.A.'   5  ? 
primary 'Solares, M.J.'   6  ? 
primary 'Berry, S.'       7  ? 
primary 'Dearnaley, W.J.' 8  ? 
primary 'Kelly, D.F.'     9  ? 
1       'Casasanta, M.A.' 10 ? 
1       'Jonaid, G.M.'    11 ? 
1       'Kaylor, L.'      12 ? 
1       'Luqiu, W.Y.'     13 ? 
1       'DiCecco, L.A.'   14 ? 
1       'Solares, M.J.'   15 ? 
1       'Berry, S.'       16 ? 
1       'Dearnaley, W.J.' 17 ? 
1       'Kelly, D.F.'     18 ? 
2       'Casasanta, M.A.' 19 ? 
2       'Jonaid, G.M.'    20 ? 
2       'Kaylor, L.'      21 ? 
2       'Luqiu, W.Y.'     22 ? 
2       'Solares, M.J.'   23 ? 
2       'Schroen, M.L.'   24 ? 
2       'Dearnaley, W.J.' 25 ? 
2       'Wilson, J.'      26 ? 
2       'Dukes, M.J.'     27 ? 
2       'Kelly, D.F.'     28 ? 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           Nucleoprotein 
_entity.formula_weight             45689.645 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'N,Nucleocapsid protein,NC,Protein N' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSP
DDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQ
LPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQ
QQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRI
GMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADL
DDFSKQLQQSMSSADSTQA
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSP
DDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQ
LPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQ
QQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRI
GMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADL
DDFSKQLQQSMSSADSTQA
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   ASP n 
1 4   ASN n 
1 5   GLY n 
1 6   PRO n 
1 7   GLN n 
1 8   ASN n 
1 9   GLN n 
1 10  ARG n 
1 11  ASN n 
1 12  ALA n 
1 13  PRO n 
1 14  ARG n 
1 15  ILE n 
1 16  THR n 
1 17  PHE n 
1 18  GLY n 
1 19  GLY n 
1 20  PRO n 
1 21  SER n 
1 22  ASP n 
1 23  SER n 
1 24  THR n 
1 25  GLY n 
1 26  SER n 
1 27  ASN n 
1 28  GLN n 
1 29  ASN n 
1 30  GLY n 
1 31  GLU n 
1 32  ARG n 
1 33  SER n 
1 34  GLY n 
1 35  ALA n 
1 36  ARG n 
1 37  SER n 
1 38  LYS n 
1 39  GLN n 
1 40  ARG n 
1 41  ARG n 
1 42  PRO n 
1 43  GLN n 
1 44  GLY n 
1 45  LEU n 
1 46  PRO n 
1 47  ASN n 
1 48  ASN n 
1 49  THR n 
1 50  ALA n 
1 51  SER n 
1 52  TRP n 
1 53  PHE n 
1 54  THR n 
1 55  ALA n 
1 56  LEU n 
1 57  THR n 
1 58  GLN n 
1 59  HIS n 
1 60  GLY n 
1 61  LYS n 
1 62  GLU n 
1 63  ASP n 
1 64  LEU n 
1 65  LYS n 
1 66  PHE n 
1 67  PRO n 
1 68  ARG n 
1 69  GLY n 
1 70  GLN n 
1 71  GLY n 
1 72  VAL n 
1 73  PRO n 
1 74  ILE n 
1 75  ASN n 
1 76  THR n 
1 77  ASN n 
1 78  SER n 
1 79  SER n 
1 80  PRO n 
1 81  ASP n 
1 82  ASP n 
1 83  GLN n 
1 84  ILE n 
1 85  GLY n 
1 86  TYR n 
1 87  TYR n 
1 88  ARG n 
1 89  ARG n 
1 90  ALA n 
1 91  THR n 
1 92  ARG n 
1 93  ARG n 
1 94  ILE n 
1 95  ARG n 
1 96  GLY n 
1 97  GLY n 
1 98  ASP n 
1 99  GLY n 
1 100 LYS n 
1 101 MET n 
1 102 LYS n 
1 103 ASP n 
1 104 LEU n 
1 105 SER n 
1 106 PRO n 
1 107 ARG n 
1 108 TRP n 
1 109 TYR n 
1 110 PHE n 
1 111 TYR n 
1 112 TYR n 
1 113 LEU n 
1 114 GLY n 
1 115 THR n 
1 116 GLY n 
1 117 PRO n 
1 118 GLU n 
1 119 ALA n 
1 120 GLY n 
1 121 LEU n 
1 122 PRO n 
1 123 TYR n 
1 124 GLY n 
1 125 ALA n 
1 126 ASN n 
1 127 LYS n 
1 128 ASP n 
1 129 GLY n 
1 130 ILE n 
1 131 ILE n 
1 132 TRP n 
1 133 VAL n 
1 134 ALA n 
1 135 THR n 
1 136 GLU n 
1 137 GLY n 
1 138 ALA n 
1 139 LEU n 
1 140 ASN n 
1 141 THR n 
1 142 PRO n 
1 143 LYS n 
1 144 ASP n 
1 145 HIS n 
1 146 ILE n 
1 147 GLY n 
1 148 THR n 
1 149 ARG n 
1 150 ASN n 
1 151 PRO n 
1 152 ALA n 
1 153 ASN n 
1 154 ASN n 
1 155 ALA n 
1 156 ALA n 
1 157 ILE n 
1 158 VAL n 
1 159 LEU n 
1 160 GLN n 
1 161 LEU n 
1 162 PRO n 
1 163 GLN n 
1 164 GLY n 
1 165 THR n 
1 166 THR n 
1 167 LEU n 
1 168 PRO n 
1 169 LYS n 
1 170 GLY n 
1 171 PHE n 
1 172 TYR n 
1 173 ALA n 
1 174 GLU n 
1 175 GLY n 
1 176 SER n 
1 177 ARG n 
1 178 GLY n 
1 179 GLY n 
1 180 SER n 
1 181 GLN n 
1 182 ALA n 
1 183 SER n 
1 184 SER n 
1 185 ARG n 
1 186 SER n 
1 187 SER n 
1 188 SER n 
1 189 ARG n 
1 190 SER n 
1 191 ARG n 
1 192 ASN n 
1 193 SER n 
1 194 SER n 
1 195 ARG n 
1 196 ASN n 
1 197 SER n 
1 198 THR n 
1 199 PRO n 
1 200 GLY n 
1 201 SER n 
1 202 SER n 
1 203 ARG n 
1 204 GLY n 
1 205 THR n 
1 206 SER n 
1 207 PRO n 
1 208 ALA n 
1 209 ARG n 
1 210 MET n 
1 211 ALA n 
1 212 GLY n 
1 213 ASN n 
1 214 GLY n 
1 215 GLY n 
1 216 ASP n 
1 217 ALA n 
1 218 ALA n 
1 219 LEU n 
1 220 ALA n 
1 221 LEU n 
1 222 LEU n 
1 223 LEU n 
1 224 LEU n 
1 225 ASP n 
1 226 ARG n 
1 227 LEU n 
1 228 ASN n 
1 229 GLN n 
1 230 LEU n 
1 231 GLU n 
1 232 SER n 
1 233 LYS n 
1 234 MET n 
1 235 SER n 
1 236 GLY n 
1 237 LYS n 
1 238 GLY n 
1 239 GLN n 
1 240 GLN n 
1 241 GLN n 
1 242 GLN n 
1 243 GLY n 
1 244 GLN n 
1 245 THR n 
1 246 VAL n 
1 247 THR n 
1 248 LYS n 
1 249 LYS n 
1 250 SER n 
1 251 ALA n 
1 252 ALA n 
1 253 GLU n 
1 254 ALA n 
1 255 SER n 
1 256 LYS n 
1 257 LYS n 
1 258 PRO n 
1 259 ARG n 
1 260 GLN n 
1 261 LYS n 
1 262 ARG n 
1 263 THR n 
1 264 ALA n 
1 265 THR n 
1 266 LYS n 
1 267 ALA n 
1 268 TYR n 
1 269 ASN n 
1 270 VAL n 
1 271 THR n 
1 272 GLN n 
1 273 ALA n 
1 274 PHE n 
1 275 GLY n 
1 276 ARG n 
1 277 ARG n 
1 278 GLY n 
1 279 PRO n 
1 280 GLU n 
1 281 GLN n 
1 282 THR n 
1 283 GLN n 
1 284 GLY n 
1 285 ASN n 
1 286 PHE n 
1 287 GLY n 
1 288 ASP n 
1 289 GLN n 
1 290 GLU n 
1 291 LEU n 
1 292 ILE n 
1 293 ARG n 
1 294 GLN n 
1 295 GLY n 
1 296 THR n 
1 297 ASP n 
1 298 TYR n 
1 299 LYS n 
1 300 HIS n 
1 301 TRP n 
1 302 PRO n 
1 303 GLN n 
1 304 ILE n 
1 305 ALA n 
1 306 GLN n 
1 307 PHE n 
1 308 ALA n 
1 309 PRO n 
1 310 SER n 
1 311 ALA n 
1 312 SER n 
1 313 ALA n 
1 314 PHE n 
1 315 PHE n 
1 316 GLY n 
1 317 MET n 
1 318 SER n 
1 319 ARG n 
1 320 ILE n 
1 321 GLY n 
1 322 MET n 
1 323 GLU n 
1 324 VAL n 
1 325 THR n 
1 326 PRO n 
1 327 SER n 
1 328 GLY n 
1 329 THR n 
1 330 TRP n 
1 331 LEU n 
1 332 THR n 
1 333 TYR n 
1 334 THR n 
1 335 GLY n 
1 336 ALA n 
1 337 ILE n 
1 338 LYS n 
1 339 LEU n 
1 340 ASP n 
1 341 ASP n 
1 342 LYS n 
1 343 ASP n 
1 344 PRO n 
1 345 ASN n 
1 346 PHE n 
1 347 LYS n 
1 348 ASP n 
1 349 GLN n 
1 350 VAL n 
1 351 ILE n 
1 352 LEU n 
1 353 LEU n 
1 354 ASN n 
1 355 LYS n 
1 356 HIS n 
1 357 ILE n 
1 358 ASP n 
1 359 ALA n 
1 360 TYR n 
1 361 LYS n 
1 362 THR n 
1 363 PHE n 
1 364 PRO n 
1 365 PRO n 
1 366 THR n 
1 367 GLU n 
1 368 PRO n 
1 369 LYS n 
1 370 LYS n 
1 371 ASP n 
1 372 LYS n 
1 373 LYS n 
1 374 LYS n 
1 375 LYS n 
1 376 ALA n 
1 377 ASP n 
1 378 GLU n 
1 379 THR n 
1 380 GLN n 
1 381 ALA n 
1 382 LEU n 
1 383 PRO n 
1 384 GLN n 
1 385 ARG n 
1 386 GLN n 
1 387 LYS n 
1 388 LYS n 
1 389 GLN n 
1 390 GLN n 
1 391 THR n 
1 392 VAL n 
1 393 THR n 
1 394 LEU n 
1 395 LEU n 
1 396 PRO n 
1 397 ALA n 
1 398 ALA n 
1 399 ASP n 
1 400 LEU n 
1 401 ASP n 
1 402 ASP n 
1 403 PHE n 
1 404 SER n 
1 405 LYS n 
1 406 GLN n 
1 407 LEU n 
1 408 GLN n 
1 409 GLN n 
1 410 SER n 
1 411 MET n 
1 412 SER n 
1 413 SER n 
1 414 ALA n 
1 415 ASP n 
1 416 SER n 
1 417 THR n 
1 418 GLN n 
1 419 ALA n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   419 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   SER 2   2   2   SER SER A . n 
A 1 3   ASP 3   3   3   ASP ASP A . n 
A 1 4   ASN 4   4   4   ASN ASN A . n 
A 1 5   GLY 5   5   5   GLY GLY A . n 
A 1 6   PRO 6   6   6   PRO PRO A . n 
A 1 7   GLN 7   7   7   GLN GLN A . n 
A 1 8   ASN 8   8   8   ASN ASN A . n 
A 1 9   GLN 9   9   9   GLN GLN A . n 
A 1 10  ARG 10  10  10  ARG ARG A . n 
A 1 11  ASN 11  11  11  ASN ASN A . n 
A 1 12  ALA 12  12  12  ALA ALA A . n 
A 1 13  PRO 13  13  13  PRO PRO A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  ILE 15  15  15  ILE ILE A . n 
A 1 16  THR 16  16  16  THR THR A . n 
A 1 17  PHE 17  17  17  PHE PHE A . n 
A 1 18  GLY 18  18  18  GLY GLY A . n 
A 1 19  GLY 19  19  19  GLY GLY A . n 
A 1 20  PRO 20  20  20  PRO PRO A . n 
A 1 21  SER 21  21  21  SER SER A . n 
A 1 22  ASP 22  22  22  ASP ASP A . n 
A 1 23  SER 23  23  23  SER SER A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  GLY 25  25  25  GLY GLY A . n 
A 1 26  SER 26  26  26  SER SER A . n 
A 1 27  ASN 27  27  27  ASN ASN A . n 
A 1 28  GLN 28  28  28  GLN GLN A . n 
A 1 29  ASN 29  29  29  ASN ASN A . n 
A 1 30  GLY 30  30  30  GLY GLY A . n 
A 1 31  GLU 31  31  31  GLU GLU A . n 
A 1 32  ARG 32  32  32  ARG ARG A . n 
A 1 33  SER 33  33  33  SER SER A . n 
A 1 34  GLY 34  34  34  GLY GLY A . n 
A 1 35  ALA 35  35  35  ALA ALA A . n 
A 1 36  ARG 36  36  36  ARG ARG A . n 
A 1 37  SER 37  37  37  SER SER A . n 
A 1 38  LYS 38  38  38  LYS LYS A . n 
A 1 39  GLN 39  39  39  GLN GLN A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  ARG 41  41  41  ARG ARG A . n 
A 1 42  PRO 42  42  42  PRO PRO A . n 
A 1 43  GLN 43  43  43  GLN GLN A . n 
A 1 44  GLY 44  44  44  GLY GLY A . n 
A 1 45  LEU 45  45  45  LEU LEU A . n 
A 1 46  PRO 46  46  46  PRO PRO A . n 
A 1 47  ASN 47  47  47  ASN ASN A . n 
A 1 48  ASN 48  48  48  ASN ASN A . n 
A 1 49  THR 49  49  49  THR THR A . n 
A 1 50  ALA 50  50  50  ALA ALA A . n 
A 1 51  SER 51  51  51  SER SER A . n 
A 1 52  TRP 52  52  52  TRP TRP A . n 
A 1 53  PHE 53  53  53  PHE PHE A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  LEU 56  56  56  LEU LEU A . n 
A 1 57  THR 57  57  57  THR THR A . n 
A 1 58  GLN 58  58  58  GLN GLN A . n 
A 1 59  HIS 59  59  59  HIS HIS A . n 
A 1 60  GLY 60  60  60  GLY GLY A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  GLU 62  62  62  GLU GLU A . n 
A 1 63  ASP 63  63  63  ASP ASP A . n 
A 1 64  LEU 64  64  64  LEU LEU A . n 
A 1 65  LYS 65  65  65  LYS LYS A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  PRO 67  67  67  PRO PRO A . n 
A 1 68  ARG 68  68  68  ARG ARG A . n 
A 1 69  GLY 69  69  69  GLY GLY A . n 
A 1 70  GLN 70  70  70  GLN GLN A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  VAL 72  72  72  VAL VAL A . n 
A 1 73  PRO 73  73  73  PRO PRO A . n 
A 1 74  ILE 74  74  74  ILE ILE A . n 
A 1 75  ASN 75  75  75  ASN ASN A . n 
A 1 76  THR 76  76  76  THR THR A . n 
A 1 77  ASN 77  77  77  ASN ASN A . n 
A 1 78  SER 78  78  78  SER SER A . n 
A 1 79  SER 79  79  79  SER SER A . n 
A 1 80  PRO 80  80  80  PRO PRO A . n 
A 1 81  ASP 81  81  81  ASP ASP A . n 
A 1 82  ASP 82  82  82  ASP ASP A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ILE 84  84  84  ILE ILE A . n 
A 1 85  GLY 85  85  85  GLY GLY A . n 
A 1 86  TYR 86  86  86  TYR TYR A . n 
A 1 87  TYR 87  87  87  TYR TYR A . n 
A 1 88  ARG 88  88  88  ARG ARG A . n 
A 1 89  ARG 89  89  89  ARG ARG A . n 
A 1 90  ALA 90  90  90  ALA ALA A . n 
A 1 91  THR 91  91  91  THR THR A . n 
A 1 92  ARG 92  92  92  ARG ARG A . n 
A 1 93  ARG 93  93  93  ARG ARG A . n 
A 1 94  ILE 94  94  94  ILE ILE A . n 
A 1 95  ARG 95  95  95  ARG ARG A . n 
A 1 96  GLY 96  96  96  GLY GLY A . n 
A 1 97  GLY 97  97  97  GLY GLY A . n 
A 1 98  ASP 98  98  98  ASP ASP A . n 
A 1 99  GLY 99  99  99  GLY GLY A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 MET 101 101 101 MET MET A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 ASP 103 103 103 ASP ASP A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 PRO 106 106 106 PRO PRO A . n 
A 1 107 ARG 107 107 107 ARG ARG A . n 
A 1 108 TRP 108 108 108 TRP TRP A . n 
A 1 109 TYR 109 109 109 TYR TYR A . n 
A 1 110 PHE 110 110 110 PHE PHE A . n 
A 1 111 TYR 111 111 111 TYR TYR A . n 
A 1 112 TYR 112 112 112 TYR TYR A . n 
A 1 113 LEU 113 113 113 LEU LEU A . n 
A 1 114 GLY 114 114 114 GLY GLY A . n 
A 1 115 THR 115 115 115 THR THR A . n 
A 1 116 GLY 116 116 116 GLY GLY A . n 
A 1 117 PRO 117 117 117 PRO PRO A . n 
A 1 118 GLU 118 118 118 GLU GLU A . n 
A 1 119 ALA 119 119 119 ALA ALA A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 LEU 121 121 121 LEU LEU A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 TYR 123 123 123 TYR TYR A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 ALA 125 125 125 ALA ALA A . n 
A 1 126 ASN 126 126 126 ASN ASN A . n 
A 1 127 LYS 127 127 127 LYS LYS A . n 
A 1 128 ASP 128 128 128 ASP ASP A . n 
A 1 129 GLY 129 129 129 GLY GLY A . n 
A 1 130 ILE 130 130 130 ILE ILE A . n 
A 1 131 ILE 131 131 131 ILE ILE A . n 
A 1 132 TRP 132 132 132 TRP TRP A . n 
A 1 133 VAL 133 133 133 VAL VAL A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 GLU 136 136 136 GLU GLU A . n 
A 1 137 GLY 137 137 137 GLY GLY A . n 
A 1 138 ALA 138 138 138 ALA ALA A . n 
A 1 139 LEU 139 139 139 LEU LEU A . n 
A 1 140 ASN 140 140 140 ASN ASN A . n 
A 1 141 THR 141 141 141 THR THR A . n 
A 1 142 PRO 142 142 142 PRO PRO A . n 
A 1 143 LYS 143 143 143 LYS LYS A . n 
A 1 144 ASP 144 144 144 ASP ASP A . n 
A 1 145 HIS 145 145 145 HIS HIS A . n 
A 1 146 ILE 146 146 146 ILE ILE A . n 
A 1 147 GLY 147 147 147 GLY GLY A . n 
A 1 148 THR 148 148 148 THR THR A . n 
A 1 149 ARG 149 149 149 ARG ARG A . n 
A 1 150 ASN 150 150 150 ASN ASN A . n 
A 1 151 PRO 151 151 151 PRO PRO A . n 
A 1 152 ALA 152 152 152 ALA ALA A . n 
A 1 153 ASN 153 153 153 ASN ASN A . n 
A 1 154 ASN 154 154 154 ASN ASN A . n 
A 1 155 ALA 155 155 155 ALA ALA A . n 
A 1 156 ALA 156 156 156 ALA ALA A . n 
A 1 157 ILE 157 157 157 ILE ILE A . n 
A 1 158 VAL 158 158 158 VAL VAL A . n 
A 1 159 LEU 159 159 159 LEU LEU A . n 
A 1 160 GLN 160 160 160 GLN GLN A . n 
A 1 161 LEU 161 161 161 LEU LEU A . n 
A 1 162 PRO 162 162 162 PRO PRO A . n 
A 1 163 GLN 163 163 163 GLN GLN A . n 
A 1 164 GLY 164 164 164 GLY GLY A . n 
A 1 165 THR 165 165 165 THR THR A . n 
A 1 166 THR 166 166 166 THR THR A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 LYS 169 169 169 LYS LYS A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 PHE 171 171 171 PHE PHE A . n 
A 1 172 TYR 172 172 172 TYR TYR A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLU 174 174 174 GLU GLU A . n 
A 1 175 GLY 175 175 175 GLY GLY A . n 
A 1 176 SER 176 176 176 SER SER A . n 
A 1 177 ARG 177 177 177 ARG ARG A . n 
A 1 178 GLY 178 178 178 GLY GLY A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 SER 180 180 180 SER SER A . n 
A 1 181 GLN 181 181 181 GLN GLN A . n 
A 1 182 ALA 182 182 182 ALA ALA A . n 
A 1 183 SER 183 183 183 SER SER A . n 
A 1 184 SER 184 184 184 SER SER A . n 
A 1 185 ARG 185 185 185 ARG ARG A . n 
A 1 186 SER 186 186 186 SER SER A . n 
A 1 187 SER 187 187 187 SER SER A . n 
A 1 188 SER 188 188 188 SER SER A . n 
A 1 189 ARG 189 189 189 ARG ARG A . n 
A 1 190 SER 190 190 190 SER SER A . n 
A 1 191 ARG 191 191 191 ARG ARG A . n 
A 1 192 ASN 192 192 192 ASN ASN A . n 
A 1 193 SER 193 193 193 SER SER A . n 
A 1 194 SER 194 194 194 SER SER A . n 
A 1 195 ARG 195 195 195 ARG ARG A . n 
A 1 196 ASN 196 196 196 ASN ASN A . n 
A 1 197 SER 197 197 197 SER SER A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 PRO 199 199 199 PRO PRO A . n 
A 1 200 GLY 200 200 200 GLY GLY A . n 
A 1 201 SER 201 201 201 SER SER A . n 
A 1 202 SER 202 202 202 SER SER A . n 
A 1 203 ARG 203 203 203 ARG ARG A . n 
A 1 204 GLY 204 204 204 GLY GLY A . n 
A 1 205 THR 205 205 205 THR THR A . n 
A 1 206 SER 206 206 206 SER SER A . n 
A 1 207 PRO 207 207 207 PRO PRO A . n 
A 1 208 ALA 208 208 208 ALA ALA A . n 
A 1 209 ARG 209 209 209 ARG ARG A . n 
A 1 210 MET 210 210 210 MET MET A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 GLY 212 212 212 GLY GLY A . n 
A 1 213 ASN 213 213 213 ASN ASN A . n 
A 1 214 GLY 214 214 214 GLY GLY A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ALA 217 217 217 ALA ALA A . n 
A 1 218 ALA 218 218 218 ALA ALA A . n 
A 1 219 LEU 219 219 219 LEU LEU A . n 
A 1 220 ALA 220 220 220 ALA ALA A . n 
A 1 221 LEU 221 221 221 LEU LEU A . n 
A 1 222 LEU 222 222 222 LEU LEU A . n 
A 1 223 LEU 223 223 223 LEU LEU A . n 
A 1 224 LEU 224 224 224 LEU LEU A . n 
A 1 225 ASP 225 225 225 ASP ASP A . n 
A 1 226 ARG 226 226 226 ARG ARG A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 GLN 229 229 229 GLN GLN A . n 
A 1 230 LEU 230 230 230 LEU LEU A . n 
A 1 231 GLU 231 231 231 GLU GLU A . n 
A 1 232 SER 232 232 232 SER SER A . n 
A 1 233 LYS 233 233 233 LYS LYS A . n 
A 1 234 MET 234 234 234 MET MET A . n 
A 1 235 SER 235 235 235 SER SER A . n 
A 1 236 GLY 236 236 236 GLY GLY A . n 
A 1 237 LYS 237 237 237 LYS LYS A . n 
A 1 238 GLY 238 238 238 GLY GLY A . n 
A 1 239 GLN 239 239 239 GLN GLN A . n 
A 1 240 GLN 240 240 240 GLN GLN A . n 
A 1 241 GLN 241 241 241 GLN GLN A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 GLY 243 243 243 GLY GLY A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 THR 245 245 245 THR THR A . n 
A 1 246 VAL 246 246 246 VAL VAL A . n 
A 1 247 THR 247 247 247 THR THR A . n 
A 1 248 LYS 248 248 248 LYS LYS A . n 
A 1 249 LYS 249 249 249 LYS LYS A . n 
A 1 250 SER 250 250 250 SER SER A . n 
A 1 251 ALA 251 251 251 ALA ALA A . n 
A 1 252 ALA 252 252 252 ALA ALA A . n 
A 1 253 GLU 253 253 253 GLU GLU A . n 
A 1 254 ALA 254 254 254 ALA ALA A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 LYS 256 256 256 LYS LYS A . n 
A 1 257 LYS 257 257 257 LYS LYS A . n 
A 1 258 PRO 258 258 258 PRO PRO A . n 
A 1 259 ARG 259 259 259 ARG ARG A . n 
A 1 260 GLN 260 260 260 GLN GLN A . n 
A 1 261 LYS 261 261 261 LYS LYS A . n 
A 1 262 ARG 262 262 262 ARG ARG A . n 
A 1 263 THR 263 263 263 THR THR A . n 
A 1 264 ALA 264 264 264 ALA ALA A . n 
A 1 265 THR 265 265 265 THR THR A . n 
A 1 266 LYS 266 266 266 LYS LYS A . n 
A 1 267 ALA 267 267 267 ALA ALA A . n 
A 1 268 TYR 268 268 268 TYR TYR A . n 
A 1 269 ASN 269 269 269 ASN ASN A . n 
A 1 270 VAL 270 270 270 VAL VAL A . n 
A 1 271 THR 271 271 271 THR THR A . n 
A 1 272 GLN 272 272 272 GLN GLN A . n 
A 1 273 ALA 273 273 273 ALA ALA A . n 
A 1 274 PHE 274 274 274 PHE PHE A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 ARG 276 276 276 ARG ARG A . n 
A 1 277 ARG 277 277 277 ARG ARG A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 PRO 279 279 279 PRO PRO A . n 
A 1 280 GLU 280 280 280 GLU GLU A . n 
A 1 281 GLN 281 281 281 GLN GLN A . n 
A 1 282 THR 282 282 282 THR THR A . n 
A 1 283 GLN 283 283 283 GLN GLN A . n 
A 1 284 GLY 284 284 284 GLY GLY A . n 
A 1 285 ASN 285 285 285 ASN ASN A . n 
A 1 286 PHE 286 286 286 PHE PHE A . n 
A 1 287 GLY 287 287 287 GLY GLY A . n 
A 1 288 ASP 288 288 288 ASP ASP A . n 
A 1 289 GLN 289 289 289 GLN GLN A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 LEU 291 291 291 LEU LEU A . n 
A 1 292 ILE 292 292 292 ILE ILE A . n 
A 1 293 ARG 293 293 293 ARG ARG A . n 
A 1 294 GLN 294 294 294 GLN GLN A . n 
A 1 295 GLY 295 295 295 GLY GLY A . n 
A 1 296 THR 296 296 296 THR THR A . n 
A 1 297 ASP 297 297 297 ASP ASP A . n 
A 1 298 TYR 298 298 298 TYR TYR A . n 
A 1 299 LYS 299 299 299 LYS LYS A . n 
A 1 300 HIS 300 300 300 HIS HIS A . n 
A 1 301 TRP 301 301 301 TRP TRP A . n 
A 1 302 PRO 302 302 302 PRO PRO A . n 
A 1 303 GLN 303 303 303 GLN GLN A . n 
A 1 304 ILE 304 304 304 ILE ILE A . n 
A 1 305 ALA 305 305 305 ALA ALA A . n 
A 1 306 GLN 306 306 306 GLN GLN A . n 
A 1 307 PHE 307 307 307 PHE PHE A . n 
A 1 308 ALA 308 308 308 ALA ALA A . n 
A 1 309 PRO 309 309 309 PRO PRO A . n 
A 1 310 SER 310 310 310 SER SER A . n 
A 1 311 ALA 311 311 311 ALA ALA A . n 
A 1 312 SER 312 312 312 SER SER A . n 
A 1 313 ALA 313 313 313 ALA ALA A . n 
A 1 314 PHE 314 314 314 PHE PHE A . n 
A 1 315 PHE 315 315 315 PHE PHE A . n 
A 1 316 GLY 316 316 316 GLY GLY A . n 
A 1 317 MET 317 317 317 MET MET A . n 
A 1 318 SER 318 318 318 SER SER A . n 
A 1 319 ARG 319 319 319 ARG ARG A . n 
A 1 320 ILE 320 320 320 ILE ILE A . n 
A 1 321 GLY 321 321 321 GLY GLY A . n 
A 1 322 MET 322 322 322 MET MET A . n 
A 1 323 GLU 323 323 323 GLU GLU A . n 
A 1 324 VAL 324 324 324 VAL VAL A . n 
A 1 325 THR 325 325 325 THR THR A . n 
A 1 326 PRO 326 326 326 PRO PRO A . n 
A 1 327 SER 327 327 327 SER SER A . n 
A 1 328 GLY 328 328 328 GLY GLY A . n 
A 1 329 THR 329 329 329 THR THR A . n 
A 1 330 TRP 330 330 330 TRP TRP A . n 
A 1 331 LEU 331 331 331 LEU LEU A . n 
A 1 332 THR 332 332 332 THR THR A . n 
A 1 333 TYR 333 333 333 TYR TYR A . n 
A 1 334 THR 334 334 334 THR THR A . n 
A 1 335 GLY 335 335 335 GLY GLY A . n 
A 1 336 ALA 336 336 336 ALA ALA A . n 
A 1 337 ILE 337 337 337 ILE ILE A . n 
A 1 338 LYS 338 338 338 LYS LYS A . n 
A 1 339 LEU 339 339 339 LEU LEU A . n 
A 1 340 ASP 340 340 340 ASP ASP A . n 
A 1 341 ASP 341 341 341 ASP ASP A . n 
A 1 342 LYS 342 342 342 LYS LYS A . n 
A 1 343 ASP 343 343 343 ASP ASP A . n 
A 1 344 PRO 344 344 344 PRO PRO A . n 
A 1 345 ASN 345 345 345 ASN ASN A . n 
A 1 346 PHE 346 346 346 PHE PHE A . n 
A 1 347 LYS 347 347 347 LYS LYS A . n 
A 1 348 ASP 348 348 348 ASP ASP A . n 
A 1 349 GLN 349 349 349 GLN GLN A . n 
A 1 350 VAL 350 350 350 VAL VAL A . n 
A 1 351 ILE 351 351 351 ILE ILE A . n 
A 1 352 LEU 352 352 352 LEU LEU A . n 
A 1 353 LEU 353 353 353 LEU LEU A . n 
A 1 354 ASN 354 354 354 ASN ASN A . n 
A 1 355 LYS 355 355 355 LYS LYS A . n 
A 1 356 HIS 356 356 356 HIS HIS A . n 
A 1 357 ILE 357 357 357 ILE ILE A . n 
A 1 358 ASP 358 358 358 ASP ASP A . n 
A 1 359 ALA 359 359 359 ALA ALA A . n 
A 1 360 TYR 360 360 360 TYR TYR A . n 
A 1 361 LYS 361 361 361 LYS LYS A . n 
A 1 362 THR 362 362 362 THR THR A . n 
A 1 363 PHE 363 363 363 PHE PHE A . n 
A 1 364 PRO 364 364 364 PRO PRO A . n 
A 1 365 PRO 365 365 365 PRO PRO A . n 
A 1 366 THR 366 366 366 THR THR A . n 
A 1 367 GLU 367 367 367 GLU GLU A . n 
A 1 368 PRO 368 368 368 PRO PRO A . n 
A 1 369 LYS 369 369 369 LYS LYS A . n 
A 1 370 LYS 370 370 370 LYS LYS A . n 
A 1 371 ASP 371 371 371 ASP ASP A . n 
A 1 372 LYS 372 372 372 LYS LYS A . n 
A 1 373 LYS 373 373 373 LYS LYS A . n 
A 1 374 LYS 374 374 374 LYS LYS A . n 
A 1 375 LYS 375 375 375 LYS LYS A . n 
A 1 376 ALA 376 376 376 ALA ALA A . n 
A 1 377 ASP 377 377 377 ASP ASP A . n 
A 1 378 GLU 378 378 378 GLU GLU A . n 
A 1 379 THR 379 379 379 THR THR A . n 
A 1 380 GLN 380 380 380 GLN GLN A . n 
A 1 381 ALA 381 381 381 ALA ALA A . n 
A 1 382 LEU 382 382 382 LEU LEU A . n 
A 1 383 PRO 383 383 383 PRO PRO A . n 
A 1 384 GLN 384 384 384 GLN GLN A . n 
A 1 385 ARG 385 385 385 ARG ARG A . n 
A 1 386 GLN 386 386 386 GLN GLN A . n 
A 1 387 LYS 387 387 387 LYS LYS A . n 
A 1 388 LYS 388 388 388 LYS LYS A . n 
A 1 389 GLN 389 389 389 GLN GLN A . n 
A 1 390 GLN 390 390 390 GLN GLN A . n 
A 1 391 THR 391 391 391 THR THR A . n 
A 1 392 VAL 392 392 392 VAL VAL A . n 
A 1 393 THR 393 393 393 THR THR A . n 
A 1 394 LEU 394 394 394 LEU LEU A . n 
A 1 395 LEU 395 395 395 LEU LEU A . n 
A 1 396 PRO 396 396 396 PRO PRO A . n 
A 1 397 ALA 397 397 397 ALA ALA A . n 
A 1 398 ALA 398 398 398 ALA ALA A . n 
A 1 399 ASP 399 399 399 ASP ASP A . n 
A 1 400 LEU 400 400 400 LEU LEU A . n 
A 1 401 ASP 401 401 401 ASP ASP A . n 
A 1 402 ASP 402 402 402 ASP ASP A . n 
A 1 403 PHE 403 403 403 PHE PHE A . n 
A 1 404 SER 404 404 404 SER SER A . n 
A 1 405 LYS 405 405 405 LYS LYS A . n 
A 1 406 GLN 406 406 406 GLN GLN A . n 
A 1 407 LEU 407 407 407 LEU LEU A . n 
A 1 408 GLN 408 408 408 GLN GLN A . n 
A 1 409 GLN 409 409 409 GLN GLN A . n 
A 1 410 SER 410 410 410 SER SER A . n 
A 1 411 MET 411 411 411 MET MET A . n 
A 1 412 SER 412 412 412 SER SER A . n 
A 1 413 SER 413 413 413 SER SER A . n 
A 1 414 ALA 414 414 414 ALA ALA A . n 
A 1 415 ASP 415 415 415 ASP ASP A . n 
A 1 416 SER 416 416 416 SER SER A . n 
A 1 417 THR 417 417 417 THR THR A . n 
A 1 418 GLN 418 418 418 GLN GLN A . n 
A 1 419 ALA 419 419 419 ALA ALA A . n 
# 
_software.citation_id            ? 
_software.classification         refinement 
_software.compiler_name          ? 
_software.compiler_version       ? 
_software.contact_author         ? 
_software.contact_author_email   ? 
_software.date                   ? 
_software.description            ? 
_software.dependencies           ? 
_software.hardware               ? 
_software.language               ? 
_software.location               ? 
_software.mods                   ? 
_software.name                   PHENIX 
_software.os                     ? 
_software.os_version             ? 
_software.type                   ? 
_software.version                1.17.1_3660: 
_software.pdbx_ordinal           1 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8FD5 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8FD5 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.006  ? 3276 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 1.107  ? 4416 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 46.831 ? 456  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.057  ? 457  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.008  ? 599  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8FD5 
_struct.title                        'Nucleocapsid monomer structure from SARS-CoV-2' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8FD5 
_struct_keywords.text            'SARS-CoV-2, N protein, COVID-19, RNA binding protein, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    NCAP_SARS2 
_struct_ref.pdbx_db_accession          P0DTC9 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSP
DDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQ
LPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQ
QQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRI
GMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADL
DDFSKQLQQSMSSADSTQA
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8FD5 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 419 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTC9 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  419 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       419 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 LYS A 100 ? LEU A 104 ? LYS A 100 LEU A 104 5 ? 5  
HELX_P HELX_P2  AA2 LEU A 219 ? MET A 234 ? LEU A 219 MET A 234 1 ? 16 
HELX_P HELX_P3  AA3 ALA A 252 ? LYS A 257 ? ALA A 252 LYS A 257 5 ? 6  
HELX_P HELX_P4  AA4 PRO A 258 ? ARG A 262 ? PRO A 258 ARG A 262 5 ? 5  
HELX_P HELX_P5  AA5 ASN A 269 ? PHE A 274 ? ASN A 269 PHE A 274 1 ? 6  
HELX_P HELX_P6  AA6 ASP A 288 ? GLY A 295 ? ASP A 288 GLY A 295 1 ? 8  
HELX_P HELX_P7  AA7 HIS A 300 ? ALA A 305 ? HIS A 300 ALA A 305 1 ? 6  
HELX_P HELX_P8  AA8 SER A 310 ? PHE A 315 ? SER A 310 PHE A 315 1 ? 6  
HELX_P HELX_P9  AA9 ASN A 345 ? ILE A 357 ? ASN A 345 ILE A 357 1 ? 13 
HELX_P HELX_P10 AB1 ASP A 358 ? PHE A 363 ? ASP A 358 PHE A 363 5 ? 6  
HELX_P HELX_P11 AB2 ALA A 398 ? SER A 416 ? ALA A 398 SER A 416 1 ? 19 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LEU A 56  ? THR A 57  ? LEU A 56  THR A 57  
AA1 2 ARG A 107 ? TYR A 112 ? ARG A 107 TYR A 112 
AA1 3 GLY A 85  ? ARG A 89  ? GLY A 85  ARG A 89  
AA1 4 GLY A 129 ? ILE A 130 ? GLY A 129 ILE A 130 
AA2 1 GLY A 321 ? GLU A 323 ? GLY A 321 GLU A 323 
AA2 2 TRP A 330 ? THR A 332 ? TRP A 330 THR A 332 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 56  ? N LEU A 56  O TRP A 108 ? O TRP A 108 
AA1 2 3 O TYR A 109 ? O TYR A 109 N ARG A 88  ? N ARG A 88  
AA1 3 4 N ARG A 89  ? N ARG A 89  O GLY A 129 ? O GLY A 129 
AA2 1 2 N GLU A 323 ? N GLU A 323 O TRP A 330 ? O TRP A 330 
# 
_pdbx_entry_details.entry_id                   8FD5 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 NE A ARG 10  ? ? CZ A ARG 10  ? ? NH1 A ARG 10  ? ? 117.04 120.30 -3.26 0.50 N 
2 1 NE A ARG 149 ? ? CZ A ARG 149 ? ? NH1 A ARG 149 ? ? 117.06 120.30 -3.24 0.50 N 
3 1 NE A ARG 149 ? ? CZ A ARG 149 ? ? NH2 A ARG 149 ? ? 123.46 120.30 3.16  0.50 N 
4 1 NE A ARG 203 ? ? CZ A ARG 203 ? ? NH2 A ARG 203 ? ? 123.30 120.30 3.00  0.50 N 
5 1 NE A ARG 226 ? ? CZ A ARG 226 ? ? NH2 A ARG 226 ? ? 124.40 120.30 4.10  0.50 N 
6 1 NE A ARG 259 ? ? CZ A ARG 259 ? ? NH2 A ARG 259 ? ? 124.03 120.30 3.73  0.50 N 
7 1 NE A ARG 262 ? ? CZ A ARG 262 ? ? NH2 A ARG 262 ? ? 124.33 120.30 4.03  0.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 PRO A 20  ? ? -75.59  -167.12 
2  1 THR A 49  ? ? -104.10 -134.46 
3  1 LYS A 61  ? ? -141.83 10.32   
4  1 PRO A 67  ? ? -53.14  173.39  
5  1 PRO A 117 ? ? -56.24  172.86  
6  1 PRO A 162 ? ? -88.47  48.98   
7  1 ALA A 173 ? ? -57.50  175.92  
8  1 LEU A 219 ? ? 55.01   -137.79 
9  1 ALA A 220 ? ? 41.11   -123.42 
10 1 TYR A 298 ? ? -34.10  121.56  
11 1 PRO A 326 ? ? -63.84  0.24    
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     88 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.078 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8FD5 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   100 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'RIGID BODY FIT' 
# 
_em_3d_reconstruction.entry_id                    8FD5 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  4.57 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               20000 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          1 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       '20 mM Tris (pH 7.5), 150 mM NaCl, 10 mM MgCl2, 10 mM CaCl2' 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'A chain contains the full-length N protein' 
_em_entity_assembly.details              
;Residues 1-49 were fit into the map separately from residues 50 - 419. The 2 fragments were fit as individual rigid bodies, then refined and rebuilt. There is a missing peptide linkage between residues 49 and 50.
;
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_image_scans.entry_id                8FD5 
_em_image_scans.id                      1 
_em_image_scans.number_digital_images   ? 
_em_image_scans.details                 ? 
_em_image_scans.scanner_model           ? 
_em_image_scans.sampling_size           6 
_em_image_scans.od_range                ? 
_em_image_scans.quant_bit_size          ? 
_em_image_scans.citation_id             ? 
_em_image_scans.dimension_height        ? 
_em_image_scans.dimension_width         ? 
_em_image_scans.frames_per_image        30 
_em_image_scans.image_recording_id      1 
_em_image_scans.used_frames_per_image   ? 
# 
_em_imaging.entry_id                        8FD5 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS TALOS F200C' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'GATAN 626 SINGLE TILT LIQUID NITROGEN CRYO TRANSFER HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            200 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1000 
_em_imaging.nominal_defocus_max             5000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           45000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             BASIC 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    'SILICON NITRIDE' 
_em_sample_support.grid_mesh_size   ? 
_em_sample_support.grid_type        Homemade 
_em_sample_support.details          
'Protein samples were added to the Ni-NTA-coated microchips and incubated for 1 minute at room temperature prior to vitrification.' 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              8FD5 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   298 
_em_vitrification.instrument            'FEI VITROBOT MARK III' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               
;A Mark III Vitrobot was used to plunge samples into liquid ethane, operating at room temperature and 100% humidity with 3 - 4 seconds blot time
;
# 
_em_experiment.entry_id                8FD5 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              8FD5 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        C1 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
GLN N    N N N 74  
GLN CA   C N S 75  
GLN C    C N N 76  
GLN O    O N N 77  
GLN CB   C N N 78  
GLN CG   C N N 79  
GLN CD   C N N 80  
GLN OE1  O N N 81  
GLN NE2  N N N 82  
GLN OXT  O N N 83  
GLN H    H N N 84  
GLN H2   H N N 85  
GLN HA   H N N 86  
GLN HB2  H N N 87  
GLN HB3  H N N 88  
GLN HG2  H N N 89  
GLN HG3  H N N 90  
GLN HE21 H N N 91  
GLN HE22 H N N 92  
GLN HXT  H N N 93  
GLU N    N N N 94  
GLU CA   C N S 95  
GLU C    C N N 96  
GLU O    O N N 97  
GLU CB   C N N 98  
GLU CG   C N N 99  
GLU CD   C N N 100 
GLU OE1  O N N 101 
GLU OE2  O N N 102 
GLU OXT  O N N 103 
GLU H    H N N 104 
GLU H2   H N N 105 
GLU HA   H N N 106 
GLU HB2  H N N 107 
GLU HB3  H N N 108 
GLU HG2  H N N 109 
GLU HG3  H N N 110 
GLU HE2  H N N 111 
GLU HXT  H N N 112 
GLY N    N N N 113 
GLY CA   C N N 114 
GLY C    C N N 115 
GLY O    O N N 116 
GLY OXT  O N N 117 
GLY H    H N N 118 
GLY H2   H N N 119 
GLY HA2  H N N 120 
GLY HA3  H N N 121 
GLY HXT  H N N 122 
HIS N    N N N 123 
HIS CA   C N S 124 
HIS C    C N N 125 
HIS O    O N N 126 
HIS CB   C N N 127 
HIS CG   C Y N 128 
HIS ND1  N Y N 129 
HIS CD2  C Y N 130 
HIS CE1  C Y N 131 
HIS NE2  N Y N 132 
HIS OXT  O N N 133 
HIS H    H N N 134 
HIS H2   H N N 135 
HIS HA   H N N 136 
HIS HB2  H N N 137 
HIS HB3  H N N 138 
HIS HD1  H N N 139 
HIS HD2  H N N 140 
HIS HE1  H N N 141 
HIS HE2  H N N 142 
HIS HXT  H N N 143 
ILE N    N N N 144 
ILE CA   C N S 145 
ILE C    C N N 146 
ILE O    O N N 147 
ILE CB   C N S 148 
ILE CG1  C N N 149 
ILE CG2  C N N 150 
ILE CD1  C N N 151 
ILE OXT  O N N 152 
ILE H    H N N 153 
ILE H2   H N N 154 
ILE HA   H N N 155 
ILE HB   H N N 156 
ILE HG12 H N N 157 
ILE HG13 H N N 158 
ILE HG21 H N N 159 
ILE HG22 H N N 160 
ILE HG23 H N N 161 
ILE HD11 H N N 162 
ILE HD12 H N N 163 
ILE HD13 H N N 164 
ILE HXT  H N N 165 
LEU N    N N N 166 
LEU CA   C N S 167 
LEU C    C N N 168 
LEU O    O N N 169 
LEU CB   C N N 170 
LEU CG   C N N 171 
LEU CD1  C N N 172 
LEU CD2  C N N 173 
LEU OXT  O N N 174 
LEU H    H N N 175 
LEU H2   H N N 176 
LEU HA   H N N 177 
LEU HB2  H N N 178 
LEU HB3  H N N 179 
LEU HG   H N N 180 
LEU HD11 H N N 181 
LEU HD12 H N N 182 
LEU HD13 H N N 183 
LEU HD21 H N N 184 
LEU HD22 H N N 185 
LEU HD23 H N N 186 
LEU HXT  H N N 187 
LYS N    N N N 188 
LYS CA   C N S 189 
LYS C    C N N 190 
LYS O    O N N 191 
LYS CB   C N N 192 
LYS CG   C N N 193 
LYS CD   C N N 194 
LYS CE   C N N 195 
LYS NZ   N N N 196 
LYS OXT  O N N 197 
LYS H    H N N 198 
LYS H2   H N N 199 
LYS HA   H N N 200 
LYS HB2  H N N 201 
LYS HB3  H N N 202 
LYS HG2  H N N 203 
LYS HG3  H N N 204 
LYS HD2  H N N 205 
LYS HD3  H N N 206 
LYS HE2  H N N 207 
LYS HE3  H N N 208 
LYS HZ1  H N N 209 
LYS HZ2  H N N 210 
LYS HZ3  H N N 211 
LYS HXT  H N N 212 
MET N    N N N 213 
MET CA   C N S 214 
MET C    C N N 215 
MET O    O N N 216 
MET CB   C N N 217 
MET CG   C N N 218 
MET SD   S N N 219 
MET CE   C N N 220 
MET OXT  O N N 221 
MET H    H N N 222 
MET H2   H N N 223 
MET HA   H N N 224 
MET HB2  H N N 225 
MET HB3  H N N 226 
MET HG2  H N N 227 
MET HG3  H N N 228 
MET HE1  H N N 229 
MET HE2  H N N 230 
MET HE3  H N N 231 
MET HXT  H N N 232 
PHE N    N N N 233 
PHE CA   C N S 234 
PHE C    C N N 235 
PHE O    O N N 236 
PHE CB   C N N 237 
PHE CG   C Y N 238 
PHE CD1  C Y N 239 
PHE CD2  C Y N 240 
PHE CE1  C Y N 241 
PHE CE2  C Y N 242 
PHE CZ   C Y N 243 
PHE OXT  O N N 244 
PHE H    H N N 245 
PHE H2   H N N 246 
PHE HA   H N N 247 
PHE HB2  H N N 248 
PHE HB3  H N N 249 
PHE HD1  H N N 250 
PHE HD2  H N N 251 
PHE HE1  H N N 252 
PHE HE2  H N N 253 
PHE HZ   H N N 254 
PHE HXT  H N N 255 
PRO N    N N N 256 
PRO CA   C N S 257 
PRO C    C N N 258 
PRO O    O N N 259 
PRO CB   C N N 260 
PRO CG   C N N 261 
PRO CD   C N N 262 
PRO OXT  O N N 263 
PRO H    H N N 264 
PRO HA   H N N 265 
PRO HB2  H N N 266 
PRO HB3  H N N 267 
PRO HG2  H N N 268 
PRO HG3  H N N 269 
PRO HD2  H N N 270 
PRO HD3  H N N 271 
PRO HXT  H N N 272 
SER N    N N N 273 
SER CA   C N S 274 
SER C    C N N 275 
SER O    O N N 276 
SER CB   C N N 277 
SER OG   O N N 278 
SER OXT  O N N 279 
SER H    H N N 280 
SER H2   H N N 281 
SER HA   H N N 282 
SER HB2  H N N 283 
SER HB3  H N N 284 
SER HG   H N N 285 
SER HXT  H N N 286 
THR N    N N N 287 
THR CA   C N S 288 
THR C    C N N 289 
THR O    O N N 290 
THR CB   C N R 291 
THR OG1  O N N 292 
THR CG2  C N N 293 
THR OXT  O N N 294 
THR H    H N N 295 
THR H2   H N N 296 
THR HA   H N N 297 
THR HB   H N N 298 
THR HG1  H N N 299 
THR HG21 H N N 300 
THR HG22 H N N 301 
THR HG23 H N N 302 
THR HXT  H N N 303 
TRP N    N N N 304 
TRP CA   C N S 305 
TRP C    C N N 306 
TRP O    O N N 307 
TRP CB   C N N 308 
TRP CG   C Y N 309 
TRP CD1  C Y N 310 
TRP CD2  C Y N 311 
TRP NE1  N Y N 312 
TRP CE2  C Y N 313 
TRP CE3  C Y N 314 
TRP CZ2  C Y N 315 
TRP CZ3  C Y N 316 
TRP CH2  C Y N 317 
TRP OXT  O N N 318 
TRP H    H N N 319 
TRP H2   H N N 320 
TRP HA   H N N 321 
TRP HB2  H N N 322 
TRP HB3  H N N 323 
TRP HD1  H N N 324 
TRP HE1  H N N 325 
TRP HE3  H N N 326 
TRP HZ2  H N N 327 
TRP HZ3  H N N 328 
TRP HH2  H N N 329 
TRP HXT  H N N 330 
TYR N    N N N 331 
TYR CA   C N S 332 
TYR C    C N N 333 
TYR O    O N N 334 
TYR CB   C N N 335 
TYR CG   C Y N 336 
TYR CD1  C Y N 337 
TYR CD2  C Y N 338 
TYR CE1  C Y N 339 
TYR CE2  C Y N 340 
TYR CZ   C Y N 341 
TYR OH   O N N 342 
TYR OXT  O N N 343 
TYR H    H N N 344 
TYR H2   H N N 345 
TYR HA   H N N 346 
TYR HB2  H N N 347 
TYR HB3  H N N 348 
TYR HD1  H N N 349 
TYR HD2  H N N 350 
TYR HE1  H N N 351 
TYR HE2  H N N 352 
TYR HH   H N N 353 
TYR HXT  H N N 354 
VAL N    N N N 355 
VAL CA   C N S 356 
VAL C    C N N 357 
VAL O    O N N 358 
VAL CB   C N N 359 
VAL CG1  C N N 360 
VAL CG2  C N N 361 
VAL OXT  O N N 362 
VAL H    H N N 363 
VAL H2   H N N 364 
VAL HA   H N N 365 
VAL HB   H N N 366 
VAL HG11 H N N 367 
VAL HG12 H N N 368 
VAL HG13 H N N 369 
VAL HG21 H N N 370 
VAL HG22 H N N 371 
VAL HG23 H N N 372 
VAL HXT  H N N 373 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
ILE N   CA   sing N N 137 
ILE N   H    sing N N 138 
ILE N   H2   sing N N 139 
ILE CA  C    sing N N 140 
ILE CA  CB   sing N N 141 
ILE CA  HA   sing N N 142 
ILE C   O    doub N N 143 
ILE C   OXT  sing N N 144 
ILE CB  CG1  sing N N 145 
ILE CB  CG2  sing N N 146 
ILE CB  HB   sing N N 147 
ILE CG1 CD1  sing N N 148 
ILE CG1 HG12 sing N N 149 
ILE CG1 HG13 sing N N 150 
ILE CG2 HG21 sing N N 151 
ILE CG2 HG22 sing N N 152 
ILE CG2 HG23 sing N N 153 
ILE CD1 HD11 sing N N 154 
ILE CD1 HD12 sing N N 155 
ILE CD1 HD13 sing N N 156 
ILE OXT HXT  sing N N 157 
LEU N   CA   sing N N 158 
LEU N   H    sing N N 159 
LEU N   H2   sing N N 160 
LEU CA  C    sing N N 161 
LEU CA  CB   sing N N 162 
LEU CA  HA   sing N N 163 
LEU C   O    doub N N 164 
LEU C   OXT  sing N N 165 
LEU CB  CG   sing N N 166 
LEU CB  HB2  sing N N 167 
LEU CB  HB3  sing N N 168 
LEU CG  CD1  sing N N 169 
LEU CG  CD2  sing N N 170 
LEU CG  HG   sing N N 171 
LEU CD1 HD11 sing N N 172 
LEU CD1 HD12 sing N N 173 
LEU CD1 HD13 sing N N 174 
LEU CD2 HD21 sing N N 175 
LEU CD2 HD22 sing N N 176 
LEU CD2 HD23 sing N N 177 
LEU OXT HXT  sing N N 178 
LYS N   CA   sing N N 179 
LYS N   H    sing N N 180 
LYS N   H2   sing N N 181 
LYS CA  C    sing N N 182 
LYS CA  CB   sing N N 183 
LYS CA  HA   sing N N 184 
LYS C   O    doub N N 185 
LYS C   OXT  sing N N 186 
LYS CB  CG   sing N N 187 
LYS CB  HB2  sing N N 188 
LYS CB  HB3  sing N N 189 
LYS CG  CD   sing N N 190 
LYS CG  HG2  sing N N 191 
LYS CG  HG3  sing N N 192 
LYS CD  CE   sing N N 193 
LYS CD  HD2  sing N N 194 
LYS CD  HD3  sing N N 195 
LYS CE  NZ   sing N N 196 
LYS CE  HE2  sing N N 197 
LYS CE  HE3  sing N N 198 
LYS NZ  HZ1  sing N N 199 
LYS NZ  HZ2  sing N N 200 
LYS NZ  HZ3  sing N N 201 
LYS OXT HXT  sing N N 202 
MET N   CA   sing N N 203 
MET N   H    sing N N 204 
MET N   H2   sing N N 205 
MET CA  C    sing N N 206 
MET CA  CB   sing N N 207 
MET CA  HA   sing N N 208 
MET C   O    doub N N 209 
MET C   OXT  sing N N 210 
MET CB  CG   sing N N 211 
MET CB  HB2  sing N N 212 
MET CB  HB3  sing N N 213 
MET CG  SD   sing N N 214 
MET CG  HG2  sing N N 215 
MET CG  HG3  sing N N 216 
MET SD  CE   sing N N 217 
MET CE  HE1  sing N N 218 
MET CE  HE2  sing N N 219 
MET CE  HE3  sing N N 220 
MET OXT HXT  sing N N 221 
PHE N   CA   sing N N 222 
PHE N   H    sing N N 223 
PHE N   H2   sing N N 224 
PHE CA  C    sing N N 225 
PHE CA  CB   sing N N 226 
PHE CA  HA   sing N N 227 
PHE C   O    doub N N 228 
PHE C   OXT  sing N N 229 
PHE CB  CG   sing N N 230 
PHE CB  HB2  sing N N 231 
PHE CB  HB3  sing N N 232 
PHE CG  CD1  doub Y N 233 
PHE CG  CD2  sing Y N 234 
PHE CD1 CE1  sing Y N 235 
PHE CD1 HD1  sing N N 236 
PHE CD2 CE2  doub Y N 237 
PHE CD2 HD2  sing N N 238 
PHE CE1 CZ   doub Y N 239 
PHE CE1 HE1  sing N N 240 
PHE CE2 CZ   sing Y N 241 
PHE CE2 HE2  sing N N 242 
PHE CZ  HZ   sing N N 243 
PHE OXT HXT  sing N N 244 
PRO N   CA   sing N N 245 
PRO N   CD   sing N N 246 
PRO N   H    sing N N 247 
PRO CA  C    sing N N 248 
PRO CA  CB   sing N N 249 
PRO CA  HA   sing N N 250 
PRO C   O    doub N N 251 
PRO C   OXT  sing N N 252 
PRO CB  CG   sing N N 253 
PRO CB  HB2  sing N N 254 
PRO CB  HB3  sing N N 255 
PRO CG  CD   sing N N 256 
PRO CG  HG2  sing N N 257 
PRO CG  HG3  sing N N 258 
PRO CD  HD2  sing N N 259 
PRO CD  HD3  sing N N 260 
PRO OXT HXT  sing N N 261 
SER N   CA   sing N N 262 
SER N   H    sing N N 263 
SER N   H2   sing N N 264 
SER CA  C    sing N N 265 
SER CA  CB   sing N N 266 
SER CA  HA   sing N N 267 
SER C   O    doub N N 268 
SER C   OXT  sing N N 269 
SER CB  OG   sing N N 270 
SER CB  HB2  sing N N 271 
SER CB  HB3  sing N N 272 
SER OG  HG   sing N N 273 
SER OXT HXT  sing N N 274 
THR N   CA   sing N N 275 
THR N   H    sing N N 276 
THR N   H2   sing N N 277 
THR CA  C    sing N N 278 
THR CA  CB   sing N N 279 
THR CA  HA   sing N N 280 
THR C   O    doub N N 281 
THR C   OXT  sing N N 282 
THR CB  OG1  sing N N 283 
THR CB  CG2  sing N N 284 
THR CB  HB   sing N N 285 
THR OG1 HG1  sing N N 286 
THR CG2 HG21 sing N N 287 
THR CG2 HG22 sing N N 288 
THR CG2 HG23 sing N N 289 
THR OXT HXT  sing N N 290 
TRP N   CA   sing N N 291 
TRP N   H    sing N N 292 
TRP N   H2   sing N N 293 
TRP CA  C    sing N N 294 
TRP CA  CB   sing N N 295 
TRP CA  HA   sing N N 296 
TRP C   O    doub N N 297 
TRP C   OXT  sing N N 298 
TRP CB  CG   sing N N 299 
TRP CB  HB2  sing N N 300 
TRP CB  HB3  sing N N 301 
TRP CG  CD1  doub Y N 302 
TRP CG  CD2  sing Y N 303 
TRP CD1 NE1  sing Y N 304 
TRP CD1 HD1  sing N N 305 
TRP CD2 CE2  doub Y N 306 
TRP CD2 CE3  sing Y N 307 
TRP NE1 CE2  sing Y N 308 
TRP NE1 HE1  sing N N 309 
TRP CE2 CZ2  sing Y N 310 
TRP CE3 CZ3  doub Y N 311 
TRP CE3 HE3  sing N N 312 
TRP CZ2 CH2  doub Y N 313 
TRP CZ2 HZ2  sing N N 314 
TRP CZ3 CH2  sing Y N 315 
TRP CZ3 HZ3  sing N N 316 
TRP CH2 HH2  sing N N 317 
TRP OXT HXT  sing N N 318 
TYR N   CA   sing N N 319 
TYR N   H    sing N N 320 
TYR N   H2   sing N N 321 
TYR CA  C    sing N N 322 
TYR CA  CB   sing N N 323 
TYR CA  HA   sing N N 324 
TYR C   O    doub N N 325 
TYR C   OXT  sing N N 326 
TYR CB  CG   sing N N 327 
TYR CB  HB2  sing N N 328 
TYR CB  HB3  sing N N 329 
TYR CG  CD1  doub Y N 330 
TYR CG  CD2  sing Y N 331 
TYR CD1 CE1  sing Y N 332 
TYR CD1 HD1  sing N N 333 
TYR CD2 CE2  doub Y N 334 
TYR CD2 HD2  sing N N 335 
TYR CE1 CZ   doub Y N 336 
TYR CE1 HE1  sing N N 337 
TYR CE2 CZ   sing Y N 338 
TYR CE2 HE2  sing N N 339 
TYR CZ  OH   sing N N 340 
TYR OH  HH   sing N N 341 
TYR OXT HXT  sing N N 342 
VAL N   CA   sing N N 343 
VAL N   H    sing N N 344 
VAL N   H2   sing N N 345 
VAL CA  C    sing N N 346 
VAL CA  CB   sing N N 347 
VAL CA  HA   sing N N 348 
VAL C   O    doub N N 349 
VAL C   OXT  sing N N 350 
VAL CB  CG1  sing N N 351 
VAL CB  CG2  sing N N 352 
VAL CB  HB   sing N N 353 
VAL CG1 HG11 sing N N 354 
VAL CG1 HG12 sing N N 355 
VAL CG1 HG13 sing N N 356 
VAL CG2 HG21 sing N N 357 
VAL CG2 HG22 sing N N 358 
VAL CG2 HG23 sing N N 359 
VAL OXT HXT  sing N N 360 
# 
_em_admin.current_status     OBS 
_em_admin.deposition_date    2022-12-02 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           8FD5 
_em_admin.last_update        2025-03-05 
_em_admin.map_release_date   2023-01-11 
_em_admin.title              'Nucleocapsid monomer structure from SARS-CoV-2' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING ONLY' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          2697049 
_em_entity_assembly_naturalsource.organism             'Severe acute respiratory syndrome coronavirus 2' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          562 
_em_entity_assembly_recombinant.organism             'Escherichia coli' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               1 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         60 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       INTEGRATING 
_em_image_recording.film_or_detector_model              'DIRECT ELECTRON DE-12 (4k x 3k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    10 
_em_image_recording.num_real_images                     200 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   20000 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? RELION   ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 SerialEM ? 
MASKING                         ? 3  ? ? ? ?        ? 
'CTF CORRECTION'                ? 4  1 ? ? RELION   ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ?        ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?        ? 
'MODEL FITTING'                 ? 7  ? 1 ? PHENIX   ? 
OTHER                           ? 8  ? ? ? ?        ? 
'INITIAL EULER ASSIGNMENT'      ? 9  1 ? ? RELION   ? 
'FINAL EULER ASSIGNMENT'        ? 10 1 ? ? RELION   ? 
CLASSIFICATION                  ? 11 1 ? ? RELION   ? 
RECONSTRUCTION                  ? 12 1 ? ? RELION   ? 
'MODEL REFINEMENT'              ? 13 ? 1 ? ISOLDE   ? 
'VOLUME SELECTION'              ? 14 1 1 1 ?        ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ?        ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?        ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?        ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?        ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?        ? 
# 
_em_specimen.concentration           0.1 
_em_specimen.details                 'Sample was enriched using Ni-NTA coated silicon nitride microchips' 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Cancer Institute (NIH/NCI)' 'United States' R01CA193578 1 
'National Institutes of Health/National Cancer Institute (NIH/NCI)' 'United States' R01CA227261 2 
'National Institutes of Health/National Cancer Institute (NIH/NCI)' 'United States' R01CA219700 3 
# 
_atom_sites.entry_id                    8FD5 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . MET A 1 1   ? 32.854 35.822 5.939  1.00 0.55 ? 1   MET A N   1 
ATOM 2    C CA  . MET A 1 1   ? 32.529 36.311 7.328  1.00 0.55 ? 1   MET A CA  1 
ATOM 3    C C   . MET A 1 1   ? 33.670 37.100 7.928  1.00 0.55 ? 1   MET A C   1 
ATOM 4    O O   . MET A 1 1   ? 34.797 36.960 7.468  1.00 0.55 ? 1   MET A O   1 
ATOM 5    C CB  . MET A 1 1   ? 32.241 35.093 8.250  1.00 0.55 ? 1   MET A CB  1 
ATOM 6    C CG  . MET A 1 1   ? 30.905 34.377 7.986  1.00 0.55 ? 1   MET A CG  1 
ATOM 7    S SD  . MET A 1 1   ? 30.678 32.880 9.003  1.00 0.55 ? 1   MET A SD  1 
ATOM 8    C CE  . MET A 1 1   ? 30.482 33.653 10.637 1.00 0.55 ? 1   MET A CE  1 
ATOM 9    N N   . SER A 1 2   ? 33.415 37.923 8.959  1.00 0.67 ? 2   SER A N   1 
ATOM 10   C CA  . SER A 1 2   ? 34.450 38.638 9.673  1.00 0.67 ? 2   SER A CA  1 
ATOM 11   C C   . SER A 1 2   ? 33.937 38.789 11.095 1.00 0.67 ? 2   SER A C   1 
ATOM 12   O O   . SER A 1 2   ? 32.729 38.729 11.314 1.00 0.67 ? 2   SER A O   1 
ATOM 13   C CB  . SER A 1 2   ? 34.786 40.016 9.021  1.00 0.67 ? 2   SER A CB  1 
ATOM 14   O OG  . SER A 1 2   ? 33.616 40.788 8.742  1.00 0.67 ? 2   SER A OG  1 
ATOM 15   N N   . ASP A 1 3   ? 34.845 38.923 12.096 1.00 0.65 ? 3   ASP A N   1 
ATOM 16   C CA  . ASP A 1 3   ? 34.524 39.048 13.517 1.00 0.65 ? 3   ASP A CA  1 
ATOM 17   C C   . ASP A 1 3   ? 34.061 40.473 13.849 1.00 0.65 ? 3   ASP A C   1 
ATOM 18   O O   . ASP A 1 3   ? 33.522 40.749 14.912 1.00 0.65 ? 3   ASP A O   1 
ATOM 19   C CB  . ASP A 1 3   ? 35.784 38.635 14.351 1.00 0.65 ? 3   ASP A CB  1 
ATOM 20   C CG  . ASP A 1 3   ? 35.506 38.163 15.772 1.00 0.65 ? 3   ASP A CG  1 
ATOM 21   O OD1 . ASP A 1 3   ? 34.498 37.450 16.007 1.00 0.65 ? 3   ASP A OD1 1 
ATOM 22   O OD2 . ASP A 1 3   ? 36.372 38.404 16.654 1.00 0.65 ? 3   ASP A OD2 1 
ATOM 23   N N   . ASN A 1 4   ? 34.243 41.449 12.934 1.00 0.65 ? 4   ASN A N   1 
ATOM 24   C CA  . ASN A 1 4   ? 33.744 42.790 13.151 1.00 0.65 ? 4   ASN A CA  1 
ATOM 25   C C   . ASN A 1 4   ? 33.488 43.477 11.810 1.00 0.65 ? 4   ASN A C   1 
ATOM 26   O O   . ASN A 1 4   ? 33.993 43.038 10.773 1.00 0.65 ? 4   ASN A O   1 
ATOM 27   C CB  . ASN A 1 4   ? 34.672 43.612 14.094 1.00 0.65 ? 4   ASN A CB  1 
ATOM 28   C CG  . ASN A 1 4   ? 36.008 43.894 13.421 1.00 0.65 ? 4   ASN A CG  1 
ATOM 29   O OD1 . ASN A 1 4   ? 36.123 44.847 12.653 1.00 0.65 ? 4   ASN A OD1 1 
ATOM 30   N ND2 . ASN A 1 4   ? 37.034 43.046 13.645 1.00 0.65 ? 4   ASN A ND2 1 
ATOM 31   N N   . GLY A 1 5   ? 32.668 44.553 11.802 1.00 0.68 ? 5   GLY A N   1 
ATOM 32   C CA  . GLY A 1 5   ? 32.293 45.228 10.572 1.00 0.68 ? 5   GLY A CA  1 
ATOM 33   C C   . GLY A 1 5   ? 31.148 46.183 10.824 1.00 0.68 ? 5   GLY A C   1 
ATOM 34   O O   . GLY A 1 5   ? 30.902 46.526 11.984 1.00 0.68 ? 5   GLY A O   1 
ATOM 35   N N   . PRO A 1 6   ? 30.454 46.676 9.797  1.00 0.64 ? 6   PRO A N   1 
ATOM 36   C CA  . PRO A 1 6   ? 29.159 47.355 9.913  1.00 0.64 ? 6   PRO A CA  1 
ATOM 37   C C   . PRO A 1 6   ? 28.048 46.580 10.616 1.00 0.64 ? 6   PRO A C   1 
ATOM 38   O O   . PRO A 1 6   ? 28.174 45.379 10.829 1.00 0.64 ? 6   PRO A O   1 
ATOM 39   C CB  . PRO A 1 6   ? 28.766 47.677 8.458  1.00 0.64 ? 6   PRO A CB  1 
ATOM 40   C CG  . PRO A 1 6   ? 30.077 47.624 7.672  1.00 0.64 ? 6   PRO A CG  1 
ATOM 41   C CD  . PRO A 1 6   ? 30.856 46.531 8.398  1.00 0.64 ? 6   PRO A CD  1 
ATOM 42   N N   . GLN A 1 7   ? 26.958 47.284 11.004 1.00 0.62 ? 7   GLN A N   1 
ATOM 43   C CA  . GLN A 1 7   ? 25.730 46.726 11.576 1.00 0.62 ? 7   GLN A CA  1 
ATOM 44   C C   . GLN A 1 7   ? 25.891 46.064 12.944 1.00 0.62 ? 7   GLN A C   1 
ATOM 45   O O   . GLN A 1 7   ? 25.036 45.317 13.416 1.00 0.62 ? 7   GLN A O   1 
ATOM 46   C CB  . GLN A 1 7   ? 24.975 45.780 10.604 1.00 0.62 ? 7   GLN A CB  1 
ATOM 47   C CG  . GLN A 1 7   ? 24.700 46.333 9.184  1.00 0.62 ? 7   GLN A CG  1 
ATOM 48   C CD  . GLN A 1 7   ? 23.661 47.447 9.101  1.00 0.62 ? 7   GLN A CD  1 
ATOM 49   O OE1 . GLN A 1 7   ? 23.251 48.105 10.061 1.00 0.62 ? 7   GLN A OE1 1 
ATOM 50   N NE2 . GLN A 1 7   ? 23.221 47.692 7.843  1.00 0.62 ? 7   GLN A NE2 1 
ATOM 51   N N   . ASN A 1 8   ? 26.988 46.361 13.662 1.00 0.65 ? 8   ASN A N   1 
ATOM 52   C CA  . ASN A 1 8   ? 27.243 45.832 14.984 1.00 0.65 ? 8   ASN A CA  1 
ATOM 53   C C   . ASN A 1 8   ? 26.259 46.305 16.060 1.00 0.65 ? 8   ASN A C   1 
ATOM 54   O O   . ASN A 1 8   ? 25.852 47.462 16.147 1.00 0.65 ? 8   ASN A O   1 
ATOM 55   C CB  . ASN A 1 8   ? 28.735 45.974 15.385 1.00 0.65 ? 8   ASN A CB  1 
ATOM 56   C CG  . ASN A 1 8   ? 29.137 47.430 15.507 1.00 0.65 ? 8   ASN A CG  1 
ATOM 57   O OD1 . ASN A 1 8   ? 28.816 48.257 14.661 1.00 0.65 ? 8   ASN A OD1 1 
ATOM 58   N ND2 . ASN A 1 8   ? 29.873 47.784 16.584 1.00 0.65 ? 8   ASN A ND2 1 
ATOM 59   N N   . GLN A 1 9   ? 25.835 45.372 16.923 1.00 0.64 ? 9   GLN A N   1 
ATOM 60   C CA  . GLN A 1 9   ? 24.655 45.522 17.752 1.00 0.64 ? 9   GLN A CA  1 
ATOM 61   C C   . GLN A 1 9   ? 24.692 46.586 18.852 1.00 0.64 ? 9   GLN A C   1 
ATOM 62   O O   . GLN A 1 9   ? 23.673 47.220 19.150 1.00 0.64 ? 9   GLN A O   1 
ATOM 63   C CB  . GLN A 1 9   ? 24.294 44.134 18.340 1.00 0.64 ? 9   GLN A CB  1 
ATOM 64   C CG  . GLN A 1 9   ? 22.959 44.052 19.121 1.00 0.64 ? 9   GLN A CG  1 
ATOM 65   C CD  . GLN A 1 9   ? 22.795 42.710 19.846 1.00 0.64 ? 9   GLN A CD  1 
ATOM 66   O OE1 . GLN A 1 9   ? 23.676 42.249 20.582 1.00 0.64 ? 9   GLN A OE1 1 
ATOM 67   N NE2 . GLN A 1 9   ? 21.603 42.088 19.711 1.00 0.64 ? 9   GLN A NE2 1 
ATOM 68   N N   . ARG A 1 10  ? 25.849 46.773 19.523 1.00 0.60 ? 10  ARG A N   1 
ATOM 69   C CA  . ARG A 1 10  ? 25.917 47.465 20.805 1.00 0.60 ? 10  ARG A CA  1 
ATOM 70   C C   . ARG A 1 10  ? 26.754 48.744 20.807 1.00 0.60 ? 10  ARG A C   1 
ATOM 71   O O   . ARG A 1 10  ? 26.928 49.368 21.847 1.00 0.60 ? 10  ARG A O   1 
ATOM 72   C CB  . ARG A 1 10  ? 26.405 46.473 21.893 1.00 0.60 ? 10  ARG A CB  1 
ATOM 73   C CG  . ARG A 1 10  ? 25.493 45.223 21.988 1.00 0.60 ? 10  ARG A CG  1 
ATOM 74   C CD  . ARG A 1 10  ? 25.809 44.269 23.144 1.00 0.60 ? 10  ARG A CD  1 
ATOM 75   N NE  . ARG A 1 10  ? 25.002 43.042 22.867 1.00 0.60 ? 10  ARG A NE  1 
ATOM 76   C CZ  . ARG A 1 10  ? 24.582 42.135 23.753 1.00 0.60 ? 10  ARG A CZ  1 
ATOM 77   N NH1 . ARG A 1 10  ? 23.890 41.101 23.279 1.00 0.60 ? 10  ARG A NH1 1 
ATOM 78   N NH2 . ARG A 1 10  ? 24.800 42.240 25.057 1.00 0.60 ? 10  ARG A NH2 1 
ATOM 79   N N   . ASN A 1 11  ? 27.249 49.205 19.639 1.00 0.60 ? 11  ASN A N   1 
ATOM 80   C CA  . ASN A 1 11  ? 27.790 50.550 19.503 1.00 0.60 ? 11  ASN A CA  1 
ATOM 81   C C   . ASN A 1 11  ? 26.664 51.554 19.203 1.00 0.60 ? 11  ASN A C   1 
ATOM 82   O O   . ASN A 1 11  ? 26.740 52.734 19.543 1.00 0.60 ? 11  ASN A O   1 
ATOM 83   C CB  . ASN A 1 11  ? 28.878 50.536 18.402 1.00 0.60 ? 11  ASN A CB  1 
ATOM 84   C CG  . ASN A 1 11  ? 29.516 51.907 18.231 1.00 0.60 ? 11  ASN A CG  1 
ATOM 85   O OD1 . ASN A 1 11  ? 29.184 52.635 17.295 1.00 0.60 ? 11  ASN A OD1 1 
ATOM 86   N ND2 . ASN A 1 11  ? 30.432 52.281 19.145 1.00 0.60 ? 11  ASN A ND2 1 
ATOM 87   N N   . ALA A 1 12  ? 25.565 51.069 18.592 1.00 0.63 ? 12  ALA A N   1 
ATOM 88   C CA  . ALA A 1 12  ? 24.304 51.764 18.456 1.00 0.63 ? 12  ALA A CA  1 
ATOM 89   C C   . ALA A 1 12  ? 23.666 52.108 19.810 1.00 0.63 ? 12  ALA A C   1 
ATOM 90   O O   . ALA A 1 12  ? 23.988 51.451 20.802 1.00 0.63 ? 12  ALA A O   1 
ATOM 91   C CB  . ALA A 1 12  ? 23.349 50.888 17.615 1.00 0.63 ? 12  ALA A CB  1 
ATOM 92   N N   . PRO A 1 13  ? 22.781 53.101 19.951 1.00 0.55 ? 13  PRO A N   1 
ATOM 93   C CA  . PRO A 1 13  ? 22.204 53.465 21.243 1.00 0.55 ? 13  PRO A CA  1 
ATOM 94   C C   . PRO A 1 13  ? 21.199 52.433 21.746 1.00 0.55 ? 13  PRO A C   1 
ATOM 95   O O   . PRO A 1 13  ? 19.992 52.641 21.678 1.00 0.55 ? 13  PRO A O   1 
ATOM 96   C CB  . PRO A 1 13  ? 21.549 54.834 20.978 1.00 0.55 ? 13  PRO A CB  1 
ATOM 97   C CG  . PRO A 1 13  ? 21.208 54.807 19.486 1.00 0.55 ? 13  PRO A CG  1 
ATOM 98   C CD  . PRO A 1 13  ? 22.362 54.006 18.884 1.00 0.55 ? 13  PRO A CD  1 
ATOM 99   N N   . ARG A 1 14  ? 21.705 51.323 22.306 1.00 0.52 ? 14  ARG A N   1 
ATOM 100  C CA  . ARG A 1 14  ? 20.947 50.185 22.783 1.00 0.52 ? 14  ARG A CA  1 
ATOM 101  C C   . ARG A 1 14  ? 20.401 50.388 24.194 1.00 0.52 ? 14  ARG A C   1 
ATOM 102  O O   . ARG A 1 14  ? 19.597 49.603 24.690 1.00 0.52 ? 14  ARG A O   1 
ATOM 103  C CB  . ARG A 1 14  ? 21.913 48.963 22.759 1.00 0.52 ? 14  ARG A CB  1 
ATOM 104  C CG  . ARG A 1 14  ? 21.271 47.559 22.853 1.00 0.52 ? 14  ARG A CG  1 
ATOM 105  C CD  . ARG A 1 14  ? 20.252 47.204 21.762 1.00 0.52 ? 14  ARG A CD  1 
ATOM 106  N NE  . ARG A 1 14  ? 20.947 47.283 20.431 1.00 0.52 ? 14  ARG A NE  1 
ATOM 107  C CZ  . ARG A 1 14  ? 20.318 47.347 19.249 1.00 0.52 ? 14  ARG A CZ  1 
ATOM 108  N NH1 . ARG A 1 14  ? 21.046 47.512 18.148 1.00 0.52 ? 14  ARG A NH1 1 
ATOM 109  N NH2 . ARG A 1 14  ? 18.998 47.246 19.161 1.00 0.52 ? 14  ARG A NH2 1 
ATOM 110  N N   . ILE A 1 15  ? 20.851 51.461 24.872 1.00 0.50 ? 15  ILE A N   1 
ATOM 111  C CA  . ILE A 1 15  ? 20.581 51.731 26.274 1.00 0.50 ? 15  ILE A CA  1 
ATOM 112  C C   . ILE A 1 15  ? 19.511 52.808 26.491 1.00 0.50 ? 15  ILE A C   1 
ATOM 113  O O   . ILE A 1 15  ? 19.126 53.123 27.621 1.00 0.50 ? 15  ILE A O   1 
ATOM 114  C CB  . ILE A 1 15  ? 21.906 52.108 26.942 1.00 0.50 ? 15  ILE A CB  1 
ATOM 115  C CG1 . ILE A 1 15  ? 21.864 51.991 28.484 1.00 0.50 ? 15  ILE A CG1 1 
ATOM 116  C CG2 . ILE A 1 15  ? 22.414 53.491 26.461 1.00 0.50 ? 15  ILE A CG2 1 
ATOM 117  C CD1 . ILE A 1 15  ? 23.264 51.849 29.094 1.00 0.50 ? 15  ILE A CD1 1 
ATOM 118  N N   . THR A 1 16  ? 18.979 53.422 25.411 1.00 0.45 ? 16  THR A N   1 
ATOM 119  C CA  . THR A 1 16  ? 17.917 54.424 25.502 1.00 0.45 ? 16  THR A CA  1 
ATOM 120  C C   . THR A 1 16  ? 16.534 53.828 25.693 1.00 0.45 ? 16  THR A C   1 
ATOM 121  O O   . THR A 1 16  ? 15.771 54.298 26.533 1.00 0.45 ? 16  THR A O   1 
ATOM 122  C CB  . THR A 1 16  ? 17.859 55.362 24.302 1.00 0.45 ? 16  THR A CB  1 
ATOM 123  O OG1 . THR A 1 16  ? 17.764 54.628 23.092 1.00 0.45 ? 16  THR A OG1 1 
ATOM 124  C CG2 . THR A 1 16  ? 19.147 56.196 24.227 1.00 0.45 ? 16  THR A CG2 1 
ATOM 125  N N   . PHE A 1 17  ? 16.175 52.781 24.931 1.00 0.36 ? 17  PHE A N   1 
ATOM 126  C CA  . PHE A 1 17  ? 14.889 52.123 25.017 1.00 0.36 ? 17  PHE A CA  1 
ATOM 127  C C   . PHE A 1 17  ? 15.083 50.696 24.514 1.00 0.36 ? 17  PHE A C   1 
ATOM 128  O O   . PHE A 1 17  ? 16.012 50.417 23.759 1.00 0.36 ? 17  PHE A O   1 
ATOM 129  C CB  . PHE A 1 17  ? 13.817 52.909 24.198 1.00 0.36 ? 17  PHE A CB  1 
ATOM 130  C CG  . PHE A 1 17  ? 12.429 52.314 24.223 1.00 0.36 ? 17  PHE A CG  1 
ATOM 131  C CD1 . PHE A 1 17  ? 11.759 52.078 25.434 1.00 0.36 ? 17  PHE A CD1 1 
ATOM 132  C CD2 . PHE A 1 17  ? 11.786 51.974 23.021 1.00 0.36 ? 17  PHE A CD2 1 
ATOM 133  C CE1 . PHE A 1 17  ? 10.476 51.513 25.444 1.00 0.36 ? 17  PHE A CE1 1 
ATOM 134  C CE2 . PHE A 1 17  ? 10.501 51.423 23.025 1.00 0.36 ? 17  PHE A CE2 1 
ATOM 135  C CZ  . PHE A 1 17  ? 9.842  51.195 24.238 1.00 0.36 ? 17  PHE A CZ  1 
ATOM 136  N N   . GLY A 1 18  ? 14.224 49.746 24.954 1.00 0.45 ? 18  GLY A N   1 
ATOM 137  C CA  . GLY A 1 18  ? 14.492 48.309 24.858 1.00 0.45 ? 18  GLY A CA  1 
ATOM 138  C C   . GLY A 1 18  ? 15.673 47.893 25.700 1.00 0.45 ? 18  GLY A C   1 
ATOM 139  O O   . GLY A 1 18  ? 15.866 48.414 26.794 1.00 0.45 ? 18  GLY A O   1 
ATOM 140  N N   . GLY A 1 19  ? 16.495 46.932 25.233 1.00 0.53 ? 19  GLY A N   1 
ATOM 141  C CA  . GLY A 1 19  ? 17.729 46.649 25.945 1.00 0.53 ? 19  GLY A CA  1 
ATOM 142  C C   . GLY A 1 19  ? 18.569 45.599 25.258 1.00 0.53 ? 19  GLY A C   1 
ATOM 143  O O   . GLY A 1 19  ? 18.127 44.988 24.282 1.00 0.53 ? 19  GLY A O   1 
ATOM 144  N N   . PRO A 1 20  ? 19.803 45.385 25.707 1.00 0.58 ? 20  PRO A N   1 
ATOM 145  C CA  . PRO A 1 20  ? 20.611 44.222 25.352 1.00 0.58 ? 20  PRO A CA  1 
ATOM 146  C C   . PRO A 1 20  ? 20.163 42.964 26.080 1.00 0.58 ? 20  PRO A C   1 
ATOM 147  O O   . PRO A 1 20  ? 19.096 42.942 26.681 1.00 0.58 ? 20  PRO A O   1 
ATOM 148  C CB  . PRO A 1 20  ? 22.023 44.664 25.785 1.00 0.58 ? 20  PRO A CB  1 
ATOM 149  C CG  . PRO A 1 20  ? 21.789 45.544 27.013 1.00 0.58 ? 20  PRO A CG  1 
ATOM 150  C CD  . PRO A 1 20  ? 20.456 46.226 26.714 1.00 0.58 ? 20  PRO A CD  1 
ATOM 151  N N   . SER A 1 21  ? 20.996 41.893 26.038 1.00 0.57 ? 21  SER A N   1 
ATOM 152  C CA  . SER A 1 21  ? 20.724 40.584 26.631 1.00 0.57 ? 21  SER A CA  1 
ATOM 153  C C   . SER A 1 21  ? 20.422 40.590 28.125 1.00 0.57 ? 21  SER A C   1 
ATOM 154  O O   . SER A 1 21  ? 19.599 39.803 28.583 1.00 0.57 ? 21  SER A O   1 
ATOM 155  C CB  . SER A 1 21  ? 21.892 39.570 26.415 1.00 0.57 ? 21  SER A CB  1 
ATOM 156  O OG  . SER A 1 21  ? 22.391 39.537 25.068 1.00 0.57 ? 21  SER A OG  1 
ATOM 157  N N   . ASP A 1 22  ? 21.067 41.493 28.893 1.00 0.54 ? 22  ASP A N   1 
ATOM 158  C CA  . ASP A 1 22  ? 20.933 41.611 30.331 1.00 0.54 ? 22  ASP A CA  1 
ATOM 159  C C   . ASP A 1 22  ? 20.154 42.890 30.626 1.00 0.54 ? 22  ASP A C   1 
ATOM 160  O O   . ASP A 1 22  ? 20.293 43.898 29.933 1.00 0.54 ? 22  ASP A O   1 
ATOM 161  C CB  . ASP A 1 22  ? 22.324 41.676 31.019 1.00 0.54 ? 22  ASP A CB  1 
ATOM 162  C CG  . ASP A 1 22  ? 23.097 40.376 30.825 1.00 0.54 ? 22  ASP A CG  1 
ATOM 163  O OD1 . ASP A 1 22  ? 22.482 39.354 30.433 1.00 0.54 ? 22  ASP A OD1 1 
ATOM 164  O OD2 . ASP A 1 22  ? 24.338 40.411 31.023 1.00 0.54 ? 22  ASP A OD2 1 
ATOM 165  N N   . SER A 1 23  ? 19.290 42.864 31.667 1.00 0.51 ? 23  SER A N   1 
ATOM 166  C CA  . SER A 1 23  ? 18.352 43.939 32.002 1.00 0.51 ? 23  SER A CA  1 
ATOM 167  C C   . SER A 1 23  ? 19.000 45.154 32.670 1.00 0.51 ? 23  SER A C   1 
ATOM 168  O O   . SER A 1 23  ? 18.439 46.246 32.710 1.00 0.51 ? 23  SER A O   1 
ATOM 169  C CB  . SER A 1 23  ? 17.201 43.397 32.903 1.00 0.51 ? 23  SER A CB  1 
ATOM 170  O OG  . SER A 1 23  ? 16.083 44.286 32.989 1.00 0.51 ? 23  SER A OG  1 
ATOM 171  N N   . THR A 1 24  ? 20.229 45.014 33.206 1.00 0.54 ? 24  THR A N   1 
ATOM 172  C CA  . THR A 1 24  ? 20.960 46.108 33.841 1.00 0.54 ? 24  THR A CA  1 
ATOM 173  C C   . THR A 1 24  ? 21.370 47.198 32.861 1.00 0.54 ? 24  THR A C   1 
ATOM 174  O O   . THR A 1 24  ? 22.026 46.950 31.851 1.00 0.54 ? 24  THR A O   1 
ATOM 175  C CB  . THR A 1 24  ? 22.183 45.632 34.608 1.00 0.54 ? 24  THR A CB  1 
ATOM 176  O OG1 . THR A 1 24  ? 21.804 44.588 35.490 1.00 0.54 ? 24  THR A OG1 1 
ATOM 177  C CG2 . THR A 1 24  ? 22.776 46.741 35.490 1.00 0.54 ? 24  THR A CG2 1 
ATOM 178  N N   . GLY A 1 25  ? 20.976 48.464 33.120 1.00 0.55 ? 25  GLY A N   1 
ATOM 179  C CA  . GLY A 1 25  ? 21.268 49.540 32.191 1.00 0.55 ? 25  GLY A CA  1 
ATOM 180  C C   . GLY A 1 25  ? 20.790 50.860 32.724 1.00 0.55 ? 25  GLY A C   1 
ATOM 181  O O   . GLY A 1 25  ? 20.081 50.926 33.724 1.00 0.55 ? 25  GLY A O   1 
ATOM 182  N N   . SER A 1 26  ? 21.172 51.964 32.057 1.00 0.50 ? 26  SER A N   1 
ATOM 183  C CA  . SER A 1 26  ? 20.969 53.325 32.547 1.00 0.50 ? 26  SER A CA  1 
ATOM 184  C C   . SER A 1 26  ? 19.575 53.894 32.397 1.00 0.50 ? 26  SER A C   1 
ATOM 185  O O   . SER A 1 26  ? 19.274 54.935 32.973 1.00 0.50 ? 26  SER A O   1 
ATOM 186  C CB  . SER A 1 26  ? 21.906 54.343 31.848 1.00 0.50 ? 26  SER A CB  1 
ATOM 187  O OG  . SER A 1 26  ? 23.254 53.878 31.878 1.00 0.50 ? 26  SER A OG  1 
ATOM 188  N N   . ASN A 1 27  ? 18.696 53.252 31.591 1.00 0.45 ? 27  ASN A N   1 
ATOM 189  C CA  . ASN A 1 27  ? 17.371 53.755 31.243 1.00 0.45 ? 27  ASN A CA  1 
ATOM 190  C C   . ASN A 1 27  ? 17.442 55.148 30.599 1.00 0.45 ? 27  ASN A C   1 
ATOM 191  O O   . ASN A 1 27  ? 16.821 56.111 31.044 1.00 0.45 ? 27  ASN A O   1 
ATOM 192  C CB  . ASN A 1 27  ? 16.407 53.658 32.462 1.00 0.45 ? 27  ASN A CB  1 
ATOM 193  C CG  . ASN A 1 27  ? 14.950 53.914 32.092 1.00 0.45 ? 27  ASN A CG  1 
ATOM 194  O OD1 . ASN A 1 27  ? 14.478 53.537 31.018 1.00 0.45 ? 27  ASN A OD1 1 
ATOM 195  N ND2 . ASN A 1 27  ? 14.198 54.567 33.010 1.00 0.45 ? 27  ASN A ND2 1 
ATOM 196  N N   . GLN A 1 28  ? 18.238 55.287 29.514 1.00 0.45 ? 28  GLN A N   1 
ATOM 197  C CA  . GLN A 1 28  ? 18.873 56.554 29.170 1.00 0.45 ? 28  GLN A CA  1 
ATOM 198  C C   . GLN A 1 28  ? 17.959 57.526 28.422 1.00 0.45 ? 28  GLN A C   1 
ATOM 199  O O   . GLN A 1 28  ? 18.329 58.642 28.066 1.00 0.45 ? 28  GLN A O   1 
ATOM 200  C CB  . GLN A 1 28  ? 20.150 56.244 28.334 1.00 0.45 ? 28  GLN A CB  1 
ATOM 201  C CG  . GLN A 1 28  ? 21.112 57.421 28.026 1.00 0.45 ? 28  GLN A CG  1 
ATOM 202  C CD  . GLN A 1 28  ? 21.709 58.030 29.294 1.00 0.45 ? 28  GLN A CD  1 
ATOM 203  O OE1 . GLN A 1 28  ? 21.794 57.398 30.348 1.00 0.45 ? 28  GLN A OE1 1 
ATOM 204  N NE2 . GLN A 1 28  ? 22.183 59.293 29.174 1.00 0.45 ? 28  GLN A NE2 1 
ATOM 205  N N   . ASN A 1 29  ? 16.689 57.133 28.206 1.00 0.43 ? 29  ASN A N   1 
ATOM 206  C CA  . ASN A 1 29  ? 15.622 58.007 27.758 1.00 0.43 ? 29  ASN A CA  1 
ATOM 207  C C   . ASN A 1 29  ? 15.311 59.167 28.710 1.00 0.43 ? 29  ASN A C   1 
ATOM 208  O O   . ASN A 1 29  ? 14.945 60.247 28.246 1.00 0.43 ? 29  ASN A O   1 
ATOM 209  C CB  . ASN A 1 29  ? 14.336 57.209 27.385 1.00 0.43 ? 29  ASN A CB  1 
ATOM 210  C CG  . ASN A 1 29  ? 13.767 56.392 28.546 1.00 0.43 ? 29  ASN A CG  1 
ATOM 211  O OD1 . ASN A 1 29  ? 12.955 56.893 29.319 1.00 0.43 ? 29  ASN A OD1 1 
ATOM 212  N ND2 . ASN A 1 29  ? 14.148 55.102 28.643 1.00 0.43 ? 29  ASN A ND2 1 
ATOM 213  N N   . GLY A 1 30  ? 15.452 58.966 30.044 1.00 0.49 ? 30  GLY A N   1 
ATOM 214  C CA  . GLY A 1 30  ? 15.175 59.977 31.070 1.00 0.49 ? 30  GLY A CA  1 
ATOM 215  C C   . GLY A 1 30  ? 13.756 60.483 31.074 1.00 0.49 ? 30  GLY A C   1 
ATOM 216  O O   . GLY A 1 30  ? 12.813 59.743 31.335 1.00 0.49 ? 30  GLY A O   1 
ATOM 217  N N   . GLU A 1 31  ? 13.563 61.772 30.765 1.00 0.42 ? 31  GLU A N   1 
ATOM 218  C CA  . GLU A 1 31  ? 12.264 62.386 30.615 1.00 0.42 ? 31  GLU A CA  1 
ATOM 219  C C   . GLU A 1 31  ? 11.561 62.004 29.316 1.00 0.42 ? 31  GLU A C   1 
ATOM 220  O O   . GLU A 1 31  ? 10.369 62.236 29.146 1.00 0.42 ? 31  GLU A O   1 
ATOM 221  C CB  . GLU A 1 31  ? 12.399 63.934 30.651 1.00 0.42 ? 31  GLU A CB  1 
ATOM 222  C CG  . GLU A 1 31  ? 12.956 64.497 31.987 1.00 0.42 ? 31  GLU A CG  1 
ATOM 223  C CD  . GLU A 1 31  ? 14.478 64.393 32.142 1.00 0.42 ? 31  GLU A CD  1 
ATOM 224  O OE1 . GLU A 1 31  ? 15.156 63.911 31.195 1.00 0.42 ? 31  GLU A OE1 1 
ATOM 225  O OE2 . GLU A 1 31  ? 14.964 64.793 33.226 1.00 0.42 ? 31  GLU A OE2 1 
ATOM 226  N N   . ARG A 1 32  ? 12.306 61.425 28.347 1.00 0.37 ? 32  ARG A N   1 
ATOM 227  C CA  . ARG A 1 32  ? 11.830 60.994 27.042 1.00 0.37 ? 32  ARG A CA  1 
ATOM 228  C C   . ARG A 1 32  ? 11.248 62.111 26.181 1.00 0.37 ? 32  ARG A C   1 
ATOM 229  O O   . ARG A 1 32  ? 10.301 61.938 25.418 1.00 0.37 ? 32  ARG A O   1 
ATOM 230  C CB  . ARG A 1 32  ? 10.911 59.748 27.144 1.00 0.37 ? 32  ARG A CB  1 
ATOM 231  C CG  . ARG A 1 32  ? 10.830 58.890 25.860 1.00 0.37 ? 32  ARG A CG  1 
ATOM 232  C CD  . ARG A 1 32  ? 10.074 57.580 26.088 1.00 0.37 ? 32  ARG A CD  1 
ATOM 233  N NE  . ARG A 1 32  ? 10.158 56.788 24.811 1.00 0.37 ? 32  ARG A NE  1 
ATOM 234  C CZ  . ARG A 1 32  ? 10.067 55.453 24.743 1.00 0.37 ? 32  ARG A CZ  1 
ATOM 235  N NH1 . ARG A 1 32  ? 10.182 54.832 23.570 1.00 0.37 ? 32  ARG A NH1 1 
ATOM 236  N NH2 . ARG A 1 32  ? 9.869  54.719 25.832 1.00 0.37 ? 32  ARG A NH2 1 
ATOM 237  N N   . SER A 1 33  ? 11.888 63.295 26.249 1.00 0.36 ? 33  SER A N   1 
ATOM 238  C CA  . SER A 1 33  ? 11.561 64.495 25.479 1.00 0.36 ? 33  SER A CA  1 
ATOM 239  C C   . SER A 1 33  ? 11.759 64.313 23.980 1.00 0.36 ? 33  SER A C   1 
ATOM 240  O O   . SER A 1 33  ? 10.992 64.803 23.158 1.00 0.36 ? 33  SER A O   1 
ATOM 241  C CB  . SER A 1 33  ? 12.370 65.711 26.016 1.00 0.36 ? 33  SER A CB  1 
ATOM 242  O OG  . SER A 1 33  ? 12.055 66.936 25.349 1.00 0.36 ? 33  SER A OG  1 
ATOM 243  N N   . GLY A 1 34  ? 12.811 63.564 23.575 1.00 0.37 ? 34  GLY A N   1 
ATOM 244  C CA  . GLY A 1 34  ? 13.010 63.237 22.163 1.00 0.37 ? 34  GLY A CA  1 
ATOM 245  C C   . GLY A 1 34  ? 13.635 64.312 21.322 1.00 0.37 ? 34  GLY A C   1 
ATOM 246  O O   . GLY A 1 34  ? 13.570 64.269 20.102 1.00 0.37 ? 34  GLY A O   1 
ATOM 247  N N   . ALA A 1 35  ? 14.280 65.300 21.963 1.00 0.29 ? 35  ALA A N   1 
ATOM 248  C CA  . ALA A 1 35  ? 14.764 66.505 21.321 1.00 0.29 ? 35  ALA A CA  1 
ATOM 249  C C   . ALA A 1 35  ? 16.011 66.352 20.447 1.00 0.29 ? 35  ALA A C   1 
ATOM 250  O O   . ALA A 1 35  ? 16.368 67.247 19.685 1.00 0.29 ? 35  ALA A O   1 
ATOM 251  C CB  . ALA A 1 35  ? 15.061 67.526 22.438 1.00 0.29 ? 35  ALA A CB  1 
ATOM 252  N N   . ARG A 1 36  ? 16.741 65.225 20.568 1.00 0.23 ? 36  ARG A N   1 
ATOM 253  C CA  . ARG A 1 36  ? 17.935 64.954 19.789 1.00 0.23 ? 36  ARG A CA  1 
ATOM 254  C C   . ARG A 1 36  ? 17.731 64.786 18.287 1.00 0.23 ? 36  ARG A C   1 
ATOM 255  O O   . ARG A 1 36  ? 16.776 64.178 17.819 1.00 0.23 ? 36  ARG A O   1 
ATOM 256  C CB  . ARG A 1 36  ? 18.711 63.734 20.345 1.00 0.23 ? 36  ARG A CB  1 
ATOM 257  C CG  . ARG A 1 36  ? 17.983 62.379 20.215 1.00 0.23 ? 36  ARG A CG  1 
ATOM 258  C CD  . ARG A 1 36  ? 18.813 61.223 20.780 1.00 0.23 ? 36  ARG A CD  1 
ATOM 259  N NE  . ARG A 1 36  ? 17.984 59.970 20.717 1.00 0.23 ? 36  ARG A NE  1 
ATOM 260  C CZ  . ARG A 1 36  ? 17.943 59.129 19.675 1.00 0.23 ? 36  ARG A CZ  1 
ATOM 261  N NH1 . ARG A 1 36  ? 17.127 58.075 19.727 1.00 0.23 ? 36  ARG A NH1 1 
ATOM 262  N NH2 . ARG A 1 36  ? 18.679 59.310 18.585 1.00 0.23 ? 36  ARG A NH2 1 
ATOM 263  N N   . SER A 1 37  ? 18.686 65.296 17.486 1.00 0.30 ? 37  SER A N   1 
ATOM 264  C CA  . SER A 1 37  ? 18.548 65.360 16.039 1.00 0.30 ? 37  SER A CA  1 
ATOM 265  C C   . SER A 1 37  ? 18.866 64.086 15.287 1.00 0.30 ? 37  SER A C   1 
ATOM 266  O O   . SER A 1 37  ? 18.488 63.921 14.131 1.00 0.30 ? 37  SER A O   1 
ATOM 267  C CB  . SER A 1 37  ? 19.516 66.416 15.458 1.00 0.30 ? 37  SER A CB  1 
ATOM 268  O OG  . SER A 1 37  ? 19.392 67.644 16.173 1.00 0.30 ? 37  SER A OG  1 
ATOM 269  N N   . LYS A 1 38  ? 19.622 63.151 15.897 1.00 0.46 ? 38  LYS A N   1 
ATOM 270  C CA  . LYS A 1 38  ? 20.126 62.010 15.161 1.00 0.46 ? 38  LYS A CA  1 
ATOM 271  C C   . LYS A 1 38  ? 20.528 60.886 16.114 1.00 0.46 ? 38  LYS A C   1 
ATOM 272  O O   . LYS A 1 38  ? 20.620 61.060 17.332 1.00 0.46 ? 38  LYS A O   1 
ATOM 273  C CB  . LYS A 1 38  ? 21.345 62.450 14.292 1.00 0.46 ? 38  LYS A CB  1 
ATOM 274  C CG  . LYS A 1 38  ? 21.687 61.558 13.085 1.00 0.46 ? 38  LYS A CG  1 
ATOM 275  C CD  . LYS A 1 38  ? 22.813 62.140 12.205 1.00 0.46 ? 38  LYS A CD  1 
ATOM 276  C CE  . LYS A 1 38  ? 24.170 62.223 12.920 1.00 0.46 ? 38  LYS A CE  1 
ATOM 277  N NZ  . LYS A 1 38  ? 25.195 62.830 12.039 1.00 0.46 ? 38  LYS A NZ  1 
ATOM 278  N N   . GLN A 1 39  ? 20.759 59.670 15.575 1.00 0.51 ? 39  GLN A N   1 
ATOM 279  C CA  . GLN A 1 39  ? 21.561 58.613 16.173 1.00 0.51 ? 39  GLN A CA  1 
ATOM 280  C C   . GLN A 1 39  ? 23.060 58.922 16.077 1.00 0.51 ? 39  GLN A C   1 
ATOM 281  O O   . GLN A 1 39  ? 23.461 59.879 15.420 1.00 0.51 ? 39  GLN A O   1 
ATOM 282  C CB  . GLN A 1 39  ? 21.265 57.264 15.469 1.00 0.51 ? 39  GLN A CB  1 
ATOM 283  C CG  . GLN A 1 39  ? 21.546 57.260 13.945 1.00 0.51 ? 39  GLN A CG  1 
ATOM 284  C CD  . GLN A 1 39  ? 21.163 55.914 13.319 1.00 0.51 ? 39  GLN A CD  1 
ATOM 285  O OE1 . GLN A 1 39  ? 21.031 54.894 14.000 1.00 0.51 ? 39  GLN A OE1 1 
ATOM 286  N NE2 . GLN A 1 39  ? 20.967 55.919 11.983 1.00 0.51 ? 39  GLN A NE2 1 
ATOM 287  N N   . ARG A 1 40  ? 23.929 58.116 16.739 1.00 0.38 ? 40  ARG A N   1 
ATOM 288  C CA  . ARG A 1 40  ? 25.374 58.346 16.791 1.00 0.38 ? 40  ARG A CA  1 
ATOM 289  C C   . ARG A 1 40  ? 26.062 58.368 15.427 1.00 0.38 ? 40  ARG A C   1 
ATOM 290  O O   . ARG A 1 40  ? 26.771 59.316 15.091 1.00 0.38 ? 40  ARG A O   1 
ATOM 291  C CB  . ARG A 1 40  ? 26.039 57.262 17.697 1.00 0.38 ? 40  ARG A CB  1 
ATOM 292  C CG  . ARG A 1 40  ? 27.560 57.423 17.956 1.00 0.38 ? 40  ARG A CG  1 
ATOM 293  C CD  . ARG A 1 40  ? 28.129 56.452 19.016 1.00 0.38 ? 40  ARG A CD  1 
ATOM 294  N NE  . ARG A 1 40  ? 29.580 56.768 19.259 1.00 0.38 ? 40  ARG A NE  1 
ATOM 295  C CZ  . ARG A 1 40  ? 30.040 57.795 19.990 1.00 0.38 ? 40  ARG A CZ  1 
ATOM 296  N NH1 . ARG A 1 40  ? 31.354 57.974 20.090 1.00 0.38 ? 40  ARG A NH1 1 
ATOM 297  N NH2 . ARG A 1 40  ? 29.228 58.644 20.607 1.00 0.38 ? 40  ARG A NH2 1 
ATOM 298  N N   . ARG A 1 41  ? 25.803 57.362 14.568 1.00 0.38 ? 41  ARG A N   1 
ATOM 299  C CA  . ARG A 1 41  ? 26.296 57.337 13.208 1.00 0.38 ? 41  ARG A CA  1 
ATOM 300  C C   . ARG A 1 41  ? 25.260 56.600 12.369 1.00 0.38 ? 41  ARG A C   1 
ATOM 301  O O   . ARG A 1 41  ? 24.537 55.777 12.933 1.00 0.38 ? 41  ARG A O   1 
ATOM 302  C CB  . ARG A 1 41  ? 27.671 56.625 13.078 1.00 0.38 ? 41  ARG A CB  1 
ATOM 303  C CG  . ARG A 1 41  ? 28.867 57.510 13.489 1.00 0.38 ? 41  ARG A CG  1 
ATOM 304  C CD  . ARG A 1 41  ? 30.241 56.857 13.290 1.00 0.38 ? 41  ARG A CD  1 
ATOM 305  N NE  . ARG A 1 41  ? 30.357 55.707 14.252 1.00 0.38 ? 41  ARG A NE  1 
ATOM 306  C CZ  . ARG A 1 41  ? 30.868 55.747 15.491 1.00 0.38 ? 41  ARG A CZ  1 
ATOM 307  N NH1 . ARG A 1 41  ? 30.866 54.648 16.238 1.00 0.38 ? 41  ARG A NH1 1 
ATOM 308  N NH2 . ARG A 1 41  ? 31.404 56.842 16.016 1.00 0.38 ? 41  ARG A NH2 1 
ATOM 309  N N   . PRO A 1 42  ? 25.091 56.864 11.072 1.00 0.47 ? 42  PRO A N   1 
ATOM 310  C CA  . PRO A 1 42  ? 24.290 56.033 10.175 1.00 0.47 ? 42  PRO A CA  1 
ATOM 311  C C   . PRO A 1 42  ? 24.688 54.568 10.055 1.00 0.47 ? 42  PRO A C   1 
ATOM 312  O O   . PRO A 1 42  ? 25.855 54.224 10.234 1.00 0.47 ? 42  PRO A O   1 
ATOM 313  C CB  . PRO A 1 42  ? 24.429 56.712 8.801  1.00 0.47 ? 42  PRO A CB  1 
ATOM 314  C CG  . PRO A 1 42  ? 24.816 58.159 9.117  1.00 0.47 ? 42  PRO A CG  1 
ATOM 315  C CD  . PRO A 1 42  ? 25.665 58.014 10.376 1.00 0.47 ? 42  PRO A CD  1 
ATOM 316  N N   . GLN A 1 43  ? 23.719 53.699 9.705  1.00 0.45 ? 43  GLN A N   1 
ATOM 317  C CA  . GLN A 1 43  ? 23.932 52.334 9.257  1.00 0.45 ? 43  GLN A CA  1 
ATOM 318  C C   . GLN A 1 43  ? 24.716 52.254 7.948  1.00 0.45 ? 43  GLN A C   1 
ATOM 319  O O   . GLN A 1 43  ? 24.673 53.152 7.110  1.00 0.45 ? 43  GLN A O   1 
ATOM 320  C CB  . GLN A 1 43  ? 22.590 51.560 9.128  1.00 0.45 ? 43  GLN A CB  1 
ATOM 321  C CG  . GLN A 1 43  ? 21.913 51.202 10.479 1.00 0.45 ? 43  GLN A CG  1 
ATOM 322  C CD  . GLN A 1 43  ? 21.365 52.417 11.232 1.00 0.45 ? 43  GLN A CD  1 
ATOM 323  O OE1 . GLN A 1 43  ? 20.945 53.418 10.645 1.00 0.45 ? 43  GLN A OE1 1 
ATOM 324  N NE2 . GLN A 1 43  ? 21.394 52.348 12.583 1.00 0.45 ? 43  GLN A NE2 1 
ATOM 325  N N   . GLY A 1 44  ? 25.479 51.154 7.754  1.00 0.40 ? 44  GLY A N   1 
ATOM 326  C CA  . GLY A 1 44  ? 26.316 50.951 6.571  1.00 0.40 ? 44  GLY A CA  1 
ATOM 327  C C   . GLY A 1 44  ? 27.767 51.295 6.764  1.00 0.40 ? 44  GLY A C   1 
ATOM 328  O O   . GLY A 1 44  ? 28.590 51.074 5.881  1.00 0.40 ? 44  GLY A O   1 
ATOM 329  N N   . LEU A 1 45  ? 28.136 51.833 7.936  1.00 0.34 ? 45  LEU A N   1 
ATOM 330  C CA  . LEU A 1 45  ? 29.479 52.296 8.206  1.00 0.34 ? 45  LEU A CA  1 
ATOM 331  C C   . LEU A 1 45  ? 30.205 51.318 9.135  1.00 0.34 ? 45  LEU A C   1 
ATOM 332  O O   . LEU A 1 45  ? 29.590 50.847 10.098 1.00 0.34 ? 45  LEU A O   1 
ATOM 333  C CB  . LEU A 1 45  ? 29.408 53.694 8.866  1.00 0.34 ? 45  LEU A CB  1 
ATOM 334  C CG  . LEU A 1 45  ? 28.753 54.788 7.990  1.00 0.34 ? 45  LEU A CG  1 
ATOM 335  C CD1 . LEU A 1 45  ? 28.560 56.079 8.798  1.00 0.34 ? 45  LEU A CD1 1 
ATOM 336  C CD2 . LEU A 1 45  ? 29.555 55.080 6.710  1.00 0.34 ? 45  LEU A CD2 1 
ATOM 337  N N   . PRO A 1 46  ? 31.470 50.926 8.920  1.00 0.53 ? 46  PRO A N   1 
ATOM 338  C CA  . PRO A 1 46  ? 32.233 50.174 9.900  1.00 0.53 ? 46  PRO A CA  1 
ATOM 339  C C   . PRO A 1 46  ? 32.580 51.020 11.087 1.00 0.53 ? 46  PRO A C   1 
ATOM 340  O O   . PRO A 1 46  ? 32.453 52.241 11.042 1.00 0.53 ? 46  PRO A O   1 
ATOM 341  C CB  . PRO A 1 46  ? 33.496 49.729 9.154  1.00 0.53 ? 46  PRO A CB  1 
ATOM 342  C CG  . PRO A 1 46  ? 33.729 50.837 8.124  1.00 0.53 ? 46  PRO A CG  1 
ATOM 343  C CD  . PRO A 1 46  ? 32.329 51.405 7.839  1.00 0.53 ? 46  PRO A CD  1 
ATOM 344  N N   . ASN A 1 47  ? 33.011 50.363 12.172 1.00 0.52 ? 47  ASN A N   1 
ATOM 345  C CA  . ASN A 1 47  ? 33.318 51.081 13.378 1.00 0.52 ? 47  ASN A CA  1 
ATOM 346  C C   . ASN A 1 47  ? 34.795 50.978 13.634 1.00 0.52 ? 47  ASN A C   1 
ATOM 347  O O   . ASN A 1 47  ? 35.391 51.944 14.102 1.00 0.52 ? 47  ASN A O   1 
ATOM 348  C CB  . ASN A 1 47  ? 32.460 50.593 14.566 1.00 0.52 ? 47  ASN A CB  1 
ATOM 349  C CG  . ASN A 1 47  ? 31.035 51.049 14.268 1.00 0.52 ? 47  ASN A CG  1 
ATOM 350  O OD1 . ASN A 1 47  ? 30.606 52.110 14.728 1.00 0.52 ? 47  ASN A OD1 1 
ATOM 351  N ND2 . ASN A 1 47  ? 30.303 50.269 13.446 1.00 0.52 ? 47  ASN A ND2 1 
ATOM 352  N N   . ASN A 1 48  ? 35.436 49.827 13.293 1.00 0.53 ? 48  ASN A N   1 
ATOM 353  C CA  . ASN A 1 48  ? 36.779 49.559 13.799 1.00 0.53 ? 48  ASN A CA  1 
ATOM 354  C C   . ASN A 1 48  ? 37.552 48.380 13.083 1.00 0.53 ? 48  ASN A C   1 
ATOM 355  O O   . ASN A 1 48  ? 36.951 47.785 12.184 1.00 0.53 ? 48  ASN A O   1 
ATOM 356  C CB  . ASN A 1 48  ? 36.563 49.454 15.331 1.00 0.53 ? 48  ASN A CB  1 
ATOM 357  C CG  . ASN A 1 48  ? 35.655 48.326 15.798 1.00 0.53 ? 48  ASN A CG  1 
ATOM 358  O OD1 . ASN A 1 48  ? 35.304 47.372 15.110 1.00 0.53 ? 48  ASN A OD1 1 
ATOM 359  N ND2 . ASN A 1 48  ? 35.231 48.438 17.088 1.00 0.53 ? 48  ASN A ND2 1 
ATOM 360  N N   . THR A 1 49  ? 38.863 48.098 13.347 1.00 0.44 ? 49  THR A N   1 
ATOM 361  C CA  . THR A 1 49  ? 39.646 46.921 12.759 1.00 0.44 ? 49  THR A CA  1 
ATOM 362  C C   . THR A 1 49  ? 39.790 45.817 13.878 1.00 0.44 ? 49  THR A C   1 
ATOM 363  O O   . THR A 1 49  ? 38.858 45.490 14.534 1.00 0.44 ? 49  THR A O   1 
ATOM 364  C CB  . THR A 1 49  ? 40.997 47.256 12.109 1.00 0.44 ? 49  THR A CB  1 
ATOM 365  O OG1 . THR A 1 49  ? 41.873 48.018 12.907 1.00 0.44 ? 49  THR A OG1 1 
ATOM 366  C CG2 . THR A 1 49  ? 40.661 48.020 10.825 1.00 0.44 ? 49  THR A CG2 1 
ATOM 367  N N   . ALA A 1 50  ? 40.952 45.166 14.155 1.00 0.45 ? 50  ALA A N   1 
ATOM 368  C CA  . ALA A 1 50  ? 41.229 44.347 15.373 1.00 0.45 ? 50  ALA A CA  1 
ATOM 369  C C   . ALA A 1 50  ? 41.895 45.106 16.548 1.00 0.45 ? 50  ALA A C   1 
ATOM 370  O O   . ALA A 1 50  ? 42.542 46.121 16.340 1.00 0.45 ? 50  ALA A O   1 
ATOM 371  C CB  . ALA A 1 50  ? 42.230 43.221 15.047 1.00 0.45 ? 50  ALA A CB  1 
ATOM 372  N N   . SER A 1 51  ? 41.840 44.626 17.831 1.00 0.33 ? 51  SER A N   1 
ATOM 373  C CA  . SER A 1 51  ? 42.585 45.188 18.984 1.00 0.33 ? 51  SER A CA  1 
ATOM 374  C C   . SER A 1 51  ? 43.457 44.089 19.510 1.00 0.33 ? 51  SER A C   1 
ATOM 375  O O   . SER A 1 51  ? 43.315 42.935 19.113 1.00 0.33 ? 51  SER A O   1 
ATOM 376  C CB  . SER A 1 51  ? 41.733 45.689 20.200 1.00 0.33 ? 51  SER A CB  1 
ATOM 377  O OG  . SER A 1 51  ? 42.428 46.173 21.351 1.00 0.33 ? 51  SER A OG  1 
ATOM 378  N N   . TRP A 1 52  ? 44.391 44.423 20.413 1.00 0.38 ? 52  TRP A N   1 
ATOM 379  C CA  . TRP A 1 52  ? 45.191 43.432 21.080 1.00 0.38 ? 52  TRP A CA  1 
ATOM 380  C C   . TRP A 1 52  ? 44.703 43.246 22.500 1.00 0.38 ? 52  TRP A C   1 
ATOM 381  O O   . TRP A 1 52  ? 44.647 44.195 23.283 1.00 0.38 ? 52  TRP A O   1 
ATOM 382  C CB  . TRP A 1 52  ? 46.679 43.813 21.078 1.00 0.38 ? 52  TRP A CB  1 
ATOM 383  C CG  . TRP A 1 52  ? 47.617 42.656 21.345 1.00 0.38 ? 52  TRP A CG  1 
ATOM 384  C CD1 . TRP A 1 52  ? 47.798 41.933 22.494 1.00 0.38 ? 52  TRP A CD1 1 
ATOM 385  C CD2 . TRP A 1 52  ? 48.464 42.045 20.359 1.00 0.38 ? 52  TRP A CD2 1 
ATOM 386  N NE1 . TRP A 1 52  ? 48.823 41.035 22.335 1.00 0.38 ? 52  TRP A NE1 1 
ATOM 387  C CE2 . TRP A 1 52  ? 49.215 41.063 21.028 1.00 0.38 ? 52  TRP A CE2 1 
ATOM 388  C CE3 . TRP A 1 52  ? 48.606 42.242 18.987 1.00 0.38 ? 52  TRP A CE3 1 
ATOM 389  C CZ2 . TRP A 1 52  ? 50.137 40.297 20.350 1.00 0.38 ? 52  TRP A CZ2 1 
ATOM 390  C CZ3 . TRP A 1 52  ? 49.511 41.424 18.291 1.00 0.38 ? 52  TRP A CZ3 1 
ATOM 391  C CH2 . TRP A 1 52  ? 50.277 40.470 18.968 1.00 0.38 ? 52  TRP A CH2 1 
ATOM 392  N N   . PHE A 1 53  ? 44.380 41.990 22.848 1.00 0.55 ? 53  PHE A N   1 
ATOM 393  C CA  . PHE A 1 53  ? 43.837 41.593 24.122 1.00 0.55 ? 53  PHE A CA  1 
ATOM 394  C C   . PHE A 1 53  ? 44.730 40.516 24.713 1.00 0.55 ? 53  PHE A C   1 
ATOM 395  O O   . PHE A 1 53  ? 45.531 39.894 24.017 1.00 0.55 ? 53  PHE A O   1 
ATOM 396  C CB  . PHE A 1 53  ? 42.396 41.030 23.971 1.00 0.55 ? 53  PHE A CB  1 
ATOM 397  C CG  . PHE A 1 53  ? 41.447 42.050 23.400 1.00 0.55 ? 53  PHE A CG  1 
ATOM 398  C CD1 . PHE A 1 53  ? 41.097 43.174 24.158 1.00 0.55 ? 53  PHE A CD1 1 
ATOM 399  C CD2 . PHE A 1 53  ? 40.851 41.878 22.136 1.00 0.55 ? 53  PHE A CD2 1 
ATOM 400  C CE1 . PHE A 1 53  ? 40.190 44.121 23.667 1.00 0.55 ? 53  PHE A CE1 1 
ATOM 401  C CE2 . PHE A 1 53  ? 39.928 42.813 21.650 1.00 0.55 ? 53  PHE A CE2 1 
ATOM 402  C CZ  . PHE A 1 53  ? 39.600 43.937 22.416 1.00 0.55 ? 53  PHE A CZ  1 
ATOM 403  N N   . THR A 1 54  ? 44.635 40.316 26.044 1.00 0.60 ? 54  THR A N   1 
ATOM 404  C CA  . THR A 1 54  ? 45.368 39.301 26.805 1.00 0.60 ? 54  THR A CA  1 
ATOM 405  C C   . THR A 1 54  ? 44.905 37.870 26.521 1.00 0.60 ? 54  THR A C   1 
ATOM 406  O O   . THR A 1 54  ? 43.745 37.664 26.178 1.00 0.60 ? 54  THR A O   1 
ATOM 407  C CB  . THR A 1 54  ? 45.275 39.547 28.313 1.00 0.60 ? 54  THR A CB  1 
ATOM 408  O OG1 . THR A 1 54  ? 45.482 40.896 28.671 1.00 0.60 ? 54  THR A OG1 1 
ATOM 409  C CG2 . THR A 1 54  ? 46.387 38.805 29.050 1.00 0.60 ? 54  THR A CG2 1 
ATOM 410  N N   . ALA A 1 55  ? 45.777 36.830 26.639 1.00 0.60 ? 55  ALA A N   1 
ATOM 411  C CA  . ALA A 1 55  ? 45.475 35.463 26.209 1.00 0.60 ? 55  ALA A CA  1 
ATOM 412  C C   . ALA A 1 55  ? 45.748 34.350 27.235 1.00 0.60 ? 55  ALA A C   1 
ATOM 413  O O   . ALA A 1 55  ? 46.838 34.249 27.788 1.00 0.60 ? 55  ALA A O   1 
ATOM 414  C CB  . ALA A 1 55  ? 46.296 35.150 24.943 1.00 0.60 ? 55  ALA A CB  1 
ATOM 415  N N   . LEU A 1 56  ? 44.752 33.459 27.454 1.00 0.62 ? 56  LEU A N   1 
ATOM 416  C CA  . LEU A 1 56  ? 44.661 32.492 28.550 1.00 0.62 ? 56  LEU A CA  1 
ATOM 417  C C   . LEU A 1 56  ? 44.712 31.051 28.027 1.00 0.62 ? 56  LEU A C   1 
ATOM 418  O O   . LEU A 1 56  ? 44.418 30.812 26.859 1.00 0.62 ? 56  LEU A O   1 
ATOM 419  C CB  . LEU A 1 56  ? 43.320 32.798 29.281 1.00 0.62 ? 56  LEU A CB  1 
ATOM 420  C CG  . LEU A 1 56  ? 42.819 31.844 30.392 1.00 0.62 ? 56  LEU A CG  1 
ATOM 421  C CD1 . LEU A 1 56  ? 42.080 32.648 31.472 1.00 0.62 ? 56  LEU A CD1 1 
ATOM 422  C CD2 . LEU A 1 56  ? 41.881 30.731 29.883 1.00 0.62 ? 56  LEU A CD2 1 
ATOM 423  N N   . THR A 1 57  ? 45.096 30.042 28.855 1.00 0.61 ? 57  THR A N   1 
ATOM 424  C CA  . THR A 1 57  ? 45.195 28.639 28.416 1.00 0.61 ? 57  THR A CA  1 
ATOM 425  C C   . THR A 1 57  ? 44.849 27.699 29.566 1.00 0.61 ? 57  THR A C   1 
ATOM 426  O O   . THR A 1 57  ? 45.250 27.903 30.707 1.00 0.61 ? 57  THR A O   1 
ATOM 427  C CB  . THR A 1 57  ? 46.583 28.266 27.869 1.00 0.61 ? 57  THR A CB  1 
ATOM 428  O OG1 . THR A 1 57  ? 46.829 28.915 26.632 1.00 0.61 ? 57  THR A OG1 1 
ATOM 429  C CG2 . THR A 1 57  ? 46.771 26.768 27.568 1.00 0.61 ? 57  THR A CG2 1 
ATOM 430  N N   . GLN A 1 58  ? 44.066 26.623 29.322 1.00 0.57 ? 58  GLN A N   1 
ATOM 431  C CA  . GLN A 1 58  ? 43.587 25.741 30.382 1.00 0.57 ? 58  GLN A CA  1 
ATOM 432  C C   . GLN A 1 58  ? 44.505 24.673 30.962 1.00 0.57 ? 58  GLN A C   1 
ATOM 433  O O   . GLN A 1 58  ? 44.459 24.463 32.164 1.00 0.57 ? 58  GLN A O   1 
ATOM 434  C CB  . GLN A 1 58  ? 42.286 25.022 29.976 1.00 0.57 ? 58  GLN A CB  1 
ATOM 435  C CG  . GLN A 1 58  ? 41.050 25.924 30.089 1.00 0.57 ? 58  GLN A CG  1 
ATOM 436  C CD  . GLN A 1 58  ? 39.818 25.074 30.378 1.00 0.57 ? 58  GLN A CD  1 
ATOM 437  O OE1 . GLN A 1 58  ? 38.996 24.769 29.513 1.00 0.57 ? 58  GLN A OE1 1 
ATOM 438  N NE2 . GLN A 1 58  ? 39.700 24.662 31.659 1.00 0.57 ? 58  GLN A NE2 1 
ATOM 439  N N   . HIS A 1 59  ? 45.270 23.922 30.139 1.00 0.52 ? 59  HIS A N   1 
ATOM 440  C CA  . HIS A 1 59  ? 45.976 22.707 30.567 1.00 0.52 ? 59  HIS A CA  1 
ATOM 441  C C   . HIS A 1 59  ? 45.038 21.648 31.164 1.00 0.52 ? 59  HIS A C   1 
ATOM 442  O O   . HIS A 1 59  ? 45.344 21.006 32.165 1.00 0.52 ? 59  HIS A O   1 
ATOM 443  C CB  . HIS A 1 59  ? 47.135 23.011 31.544 1.00 0.52 ? 59  HIS A CB  1 
ATOM 444  C CG  . HIS A 1 59  ? 48.112 24.044 31.059 1.00 0.52 ? 59  HIS A CG  1 
ATOM 445  N ND1 . HIS A 1 59  ? 49.383 23.624 30.758 1.00 0.52 ? 59  HIS A ND1 1 
ATOM 446  C CD2 . HIS A 1 59  ? 48.039 25.399 30.946 1.00 0.52 ? 59  HIS A CD2 1 
ATOM 447  C CE1 . HIS A 1 59  ? 50.066 24.701 30.482 1.00 0.52 ? 59  HIS A CE1 1 
ATOM 448  N NE2 . HIS A 1 59  ? 49.303 25.813 30.573 1.00 0.52 ? 59  HIS A NE2 1 
ATOM 449  N N   . GLY A 1 60  ? 43.832 21.465 30.580 1.00 0.54 ? 60  GLY A N   1 
ATOM 450  C CA  . GLY A 1 60  ? 42.821 20.612 31.187 1.00 0.54 ? 60  GLY A CA  1 
ATOM 451  C C   . GLY A 1 60  ? 41.441 20.802 30.603 1.00 0.54 ? 60  GLY A C   1 
ATOM 452  O O   . GLY A 1 60  ? 41.284 21.271 29.474 1.00 0.54 ? 60  GLY A O   1 
ATOM 453  N N   . LYS A 1 61  ? 40.385 20.439 31.375 1.00 0.54 ? 61  LYS A N   1 
ATOM 454  C CA  . LYS A 1 61  ? 39.030 20.328 30.860 1.00 0.54 ? 61  LYS A CA  1 
ATOM 455  C C   . LYS A 1 61  ? 37.935 20.807 31.812 1.00 0.54 ? 61  LYS A C   1 
ATOM 456  O O   . LYS A 1 61  ? 36.758 20.570 31.559 1.00 0.54 ? 61  LYS A O   1 
ATOM 457  C CB  . LYS A 1 61  ? 38.725 18.837 30.525 1.00 0.54 ? 61  LYS A CB  1 
ATOM 458  C CG  . LYS A 1 61  ? 38.734 17.877 31.736 1.00 0.54 ? 61  LYS A CG  1 
ATOM 459  C CD  . LYS A 1 61  ? 38.537 16.395 31.358 1.00 0.54 ? 61  LYS A CD  1 
ATOM 460  C CE  . LYS A 1 61  ? 37.151 16.075 30.782 1.00 0.54 ? 61  LYS A CE  1 
ATOM 461  N NZ  . LYS A 1 61  ? 37.026 14.622 30.502 1.00 0.54 ? 61  LYS A NZ  1 
ATOM 462  N N   . GLU A 1 62  ? 38.297 21.474 32.928 1.00 0.55 ? 62  GLU A N   1 
ATOM 463  C CA  . GLU A 1 62  ? 37.374 22.080 33.883 1.00 0.55 ? 62  GLU A CA  1 
ATOM 464  C C   . GLU A 1 62  ? 36.674 23.330 33.348 1.00 0.55 ? 62  GLU A C   1 
ATOM 465  O O   . GLU A 1 62  ? 37.211 24.027 32.489 1.00 0.55 ? 62  GLU A O   1 
ATOM 466  C CB  . GLU A 1 62  ? 38.133 22.387 35.196 1.00 0.55 ? 62  GLU A CB  1 
ATOM 467  C CG  . GLU A 1 62  ? 37.263 22.896 36.368 1.00 0.55 ? 62  GLU A CG  1 
ATOM 468  C CD  . GLU A 1 62  ? 37.965 22.740 37.715 1.00 0.55 ? 62  GLU A CD  1 
ATOM 469  O OE1 . GLU A 1 62  ? 39.224 22.765 37.744 1.00 0.55 ? 62  GLU A OE1 1 
ATOM 470  O OE2 . GLU A 1 62  ? 37.236 22.599 38.729 1.00 0.55 ? 62  GLU A OE2 1 
ATOM 471  N N   . ASP A 1 63  ? 35.449 23.661 33.807 1.00 0.51 ? 63  ASP A N   1 
ATOM 472  C CA  . ASP A 1 63  ? 34.739 24.849 33.367 1.00 0.51 ? 63  ASP A CA  1 
ATOM 473  C C   . ASP A 1 63  ? 35.438 26.167 33.723 1.00 0.51 ? 63  ASP A C   1 
ATOM 474  O O   . ASP A 1 63  ? 35.854 26.404 34.856 1.00 0.51 ? 63  ASP A O   1 
ATOM 475  C CB  . ASP A 1 63  ? 33.308 24.947 33.956 1.00 0.51 ? 63  ASP A CB  1 
ATOM 476  C CG  . ASP A 1 63  ? 32.342 23.857 33.502 1.00 0.51 ? 63  ASP A CG  1 
ATOM 477  O OD1 . ASP A 1 63  ? 32.680 23.010 32.651 1.00 0.51 ? 63  ASP A OD1 1 
ATOM 478  O OD2 . ASP A 1 63  ? 31.187 23.929 34.006 1.00 0.51 ? 63  ASP A OD2 1 
ATOM 479  N N   . LEU A 1 64  ? 35.522 27.113 32.763 1.00 0.57 ? 64  LEU A N   1 
ATOM 480  C CA  . LEU A 1 64  ? 35.936 28.483 33.040 1.00 0.57 ? 64  LEU A CA  1 
ATOM 481  C C   . LEU A 1 64  ? 34.789 29.267 33.687 1.00 0.57 ? 64  LEU A C   1 
ATOM 482  O O   . LEU A 1 64  ? 34.000 29.928 33.013 1.00 0.57 ? 64  LEU A O   1 
ATOM 483  C CB  . LEU A 1 64  ? 36.408 29.188 31.739 1.00 0.57 ? 64  LEU A CB  1 
ATOM 484  C CG  . LEU A 1 64  ? 37.019 30.597 31.926 1.00 0.57 ? 64  LEU A CG  1 
ATOM 485  C CD1 . LEU A 1 64  ? 38.503 30.555 32.297 1.00 0.57 ? 64  LEU A CD1 1 
ATOM 486  C CD2 . LEU A 1 64  ? 36.873 31.454 30.668 1.00 0.57 ? 64  LEU A CD2 1 
ATOM 487  N N   . LYS A 1 65  ? 34.645 29.179 35.025 1.00 0.52 ? 65  LYS A N   1 
ATOM 488  C CA  . LYS A 1 65  ? 33.531 29.756 35.754 1.00 0.52 ? 65  LYS A CA  1 
ATOM 489  C C   . LYS A 1 65  ? 33.992 30.437 37.027 1.00 0.52 ? 65  LYS A C   1 
ATOM 490  O O   . LYS A 1 65  ? 35.077 30.174 37.540 1.00 0.52 ? 65  LYS A O   1 
ATOM 491  C CB  . LYS A 1 65  ? 32.493 28.662 36.114 1.00 0.52 ? 65  LYS A CB  1 
ATOM 492  C CG  . LYS A 1 65  ? 31.588 28.302 34.927 1.00 0.52 ? 65  LYS A CG  1 
ATOM 493  C CD  . LYS A 1 65  ? 30.641 27.127 35.226 1.00 0.52 ? 65  LYS A CD  1 
ATOM 494  C CE  . LYS A 1 65  ? 29.776 26.756 34.015 1.00 0.52 ? 65  LYS A CE  1 
ATOM 495  N NZ  . LYS A 1 65  ? 29.146 25.436 34.204 1.00 0.52 ? 65  LYS A NZ  1 
ATOM 496  N N   . PHE A 1 66  ? 33.152 31.354 37.555 1.00 0.46 ? 66  PHE A N   1 
ATOM 497  C CA  . PHE A 1 66  ? 33.500 32.239 38.645 1.00 0.46 ? 66  PHE A CA  1 
ATOM 498  C C   . PHE A 1 66  ? 32.266 32.431 39.531 1.00 0.46 ? 66  PHE A C   1 
ATOM 499  O O   . PHE A 1 66  ? 31.155 32.152 39.073 1.00 0.46 ? 66  PHE A O   1 
ATOM 500  C CB  . PHE A 1 66  ? 33.892 33.642 38.108 1.00 0.46 ? 66  PHE A CB  1 
ATOM 501  C CG  . PHE A 1 66  ? 35.127 33.626 37.248 1.00 0.46 ? 66  PHE A CG  1 
ATOM 502  C CD1 . PHE A 1 66  ? 36.392 33.809 37.825 1.00 0.46 ? 66  PHE A CD1 1 
ATOM 503  C CD2 . PHE A 1 66  ? 35.029 33.508 35.851 1.00 0.46 ? 66  PHE A CD2 1 
ATOM 504  C CE1 . PHE A 1 66  ? 37.535 33.890 37.022 1.00 0.46 ? 66  PHE A CE1 1 
ATOM 505  C CE2 . PHE A 1 66  ? 36.171 33.570 35.046 1.00 0.46 ? 66  PHE A CE2 1 
ATOM 506  C CZ  . PHE A 1 66  ? 37.426 33.775 35.633 1.00 0.46 ? 66  PHE A CZ  1 
ATOM 507  N N   . PRO A 1 67  ? 32.375 32.887 40.784 1.00 0.44 ? 67  PRO A N   1 
ATOM 508  C CA  . PRO A 1 67  ? 31.277 33.486 41.551 1.00 0.44 ? 67  PRO A CA  1 
ATOM 509  C C   . PRO A 1 67  ? 30.530 34.644 40.892 1.00 0.44 ? 67  PRO A C   1 
ATOM 510  O O   . PRO A 1 67  ? 30.914 35.140 39.837 1.00 0.44 ? 67  PRO A O   1 
ATOM 511  C CB  . PRO A 1 67  ? 31.940 33.942 42.865 1.00 0.44 ? 67  PRO A CB  1 
ATOM 512  C CG  . PRO A 1 67  ? 33.201 33.087 42.980 1.00 0.44 ? 67  PRO A CG  1 
ATOM 513  C CD  . PRO A 1 67  ? 33.631 32.936 41.526 1.00 0.44 ? 67  PRO A CD  1 
ATOM 514  N N   . ARG A 1 68  ? 29.431 35.115 41.526 1.00 0.44 ? 68  ARG A N   1 
ATOM 515  C CA  . ARG A 1 68  ? 28.634 36.241 41.051 1.00 0.44 ? 68  ARG A CA  1 
ATOM 516  C C   . ARG A 1 68  ? 29.387 37.575 40.996 1.00 0.44 ? 68  ARG A C   1 
ATOM 517  O O   . ARG A 1 68  ? 29.181 38.389 40.097 1.00 0.44 ? 68  ARG A O   1 
ATOM 518  C CB  . ARG A 1 68  ? 27.335 36.387 41.896 1.00 0.44 ? 68  ARG A CB  1 
ATOM 519  C CG  . ARG A 1 68  ? 26.457 35.112 41.981 1.00 0.44 ? 68  ARG A CG  1 
ATOM 520  C CD  . ARG A 1 68  ? 26.023 34.492 40.639 1.00 0.44 ? 68  ARG A CD  1 
ATOM 521  N NE  . ARG A 1 68  ? 25.139 35.485 39.927 1.00 0.44 ? 68  ARG A NE  1 
ATOM 522  C CZ  . ARG A 1 68  ? 24.998 35.588 38.595 1.00 0.44 ? 68  ARG A CZ  1 
ATOM 523  N NH1 . ARG A 1 68  ? 24.137 36.470 38.078 1.00 0.44 ? 68  ARG A NH1 1 
ATOM 524  N NH2 . ARG A 1 68  ? 25.709 34.832 37.766 1.00 0.44 ? 68  ARG A NH2 1 
ATOM 525  N N   . GLY A 1 69  ? 30.279 37.829 41.975 1.00 0.53 ? 69  GLY A N   1 
ATOM 526  C CA  . GLY A 1 69  ? 31.171 38.980 41.974 1.00 0.53 ? 69  GLY A CA  1 
ATOM 527  C C   . GLY A 1 69  ? 32.502 38.652 41.348 1.00 0.53 ? 69  GLY A C   1 
ATOM 528  O O   . GLY A 1 69  ? 32.978 37.525 41.439 1.00 0.53 ? 69  GLY A O   1 
ATOM 529  N N   . GLN A 1 70  ? 33.132 39.663 40.711 1.00 0.55 ? 70  GLN A N   1 
ATOM 530  C CA  . GLN A 1 70  ? 34.454 39.591 40.091 1.00 0.55 ? 70  GLN A CA  1 
ATOM 531  C C   . GLN A 1 70  ? 34.605 38.559 38.974 1.00 0.55 ? 70  GLN A C   1 
ATOM 532  O O   . GLN A 1 70  ? 35.700 38.115 38.649 1.00 0.55 ? 70  GLN A O   1 
ATOM 533  C CB  . GLN A 1 70  ? 35.585 39.495 41.143 1.00 0.55 ? 70  GLN A CB  1 
ATOM 534  C CG  . GLN A 1 70  ? 35.630 40.734 42.070 1.00 0.55 ? 70  GLN A CG  1 
ATOM 535  C CD  . GLN A 1 70  ? 36.781 40.669 43.077 1.00 0.55 ? 70  GLN A CD  1 
ATOM 536  O OE1 . GLN A 1 70  ? 37.455 39.652 43.223 1.00 0.55 ? 70  GLN A OE1 1 
ATOM 537  N NE2 . GLN A 1 70  ? 36.979 41.790 43.811 1.00 0.55 ? 70  GLN A NE2 1 
ATOM 538  N N   . GLY A 1 71  ? 33.491 38.217 38.294 1.00 0.57 ? 71  GLY A N   1 
ATOM 539  C CA  . GLY A 1 71  ? 33.461 37.184 37.262 1.00 0.57 ? 71  GLY A CA  1 
ATOM 540  C C   . GLY A 1 71  ? 33.986 37.561 35.905 1.00 0.57 ? 71  GLY A C   1 
ATOM 541  O O   . GLY A 1 71  ? 34.021 36.733 35.001 1.00 0.57 ? 71  GLY A O   1 
ATOM 542  N N   . VAL A 1 72  ? 34.408 38.820 35.711 1.00 0.66 ? 72  VAL A N   1 
ATOM 543  C CA  . VAL A 1 72  ? 35.026 39.263 34.474 1.00 0.66 ? 72  VAL A CA  1 
ATOM 544  C C   . VAL A 1 72  ? 36.028 40.371 34.819 1.00 0.66 ? 72  VAL A C   1 
ATOM 545  O O   . VAL A 1 72  ? 35.772 41.082 35.797 1.00 0.66 ? 72  VAL A O   1 
ATOM 546  C CB  . VAL A 1 72  ? 33.984 39.705 33.435 1.00 0.66 ? 72  VAL A CB  1 
ATOM 547  C CG1 . VAL A 1 72  ? 33.217 40.971 33.880 1.00 0.66 ? 72  VAL A CG1 1 
ATOM 548  C CG2 . VAL A 1 72  ? 34.621 39.880 32.045 1.00 0.66 ? 72  VAL A CG2 1 
ATOM 549  N N   . PRO A 1 73  ? 37.171 40.579 34.147 1.00 0.65 ? 73  PRO A N   1 
ATOM 550  C CA  . PRO A 1 73  ? 38.144 41.602 34.541 1.00 0.65 ? 73  PRO A CA  1 
ATOM 551  C C   . PRO A 1 73  ? 37.742 43.048 34.274 1.00 0.65 ? 73  PRO A C   1 
ATOM 552  O O   . PRO A 1 73  ? 37.068 43.331 33.283 1.00 0.65 ? 73  PRO A O   1 
ATOM 553  C CB  . PRO A 1 73  ? 39.398 41.284 33.707 1.00 0.65 ? 73  PRO A CB  1 
ATOM 554  C CG  . PRO A 1 73  ? 39.279 39.797 33.390 1.00 0.65 ? 73  PRO A CG  1 
ATOM 555  C CD  . PRO A 1 73  ? 37.774 39.616 33.221 1.00 0.65 ? 73  PRO A CD  1 
ATOM 556  N N   . ILE A 1 74  ? 38.202 43.980 35.138 1.00 0.58 ? 74  ILE A N   1 
ATOM 557  C CA  . ILE A 1 74  ? 38.090 45.426 34.977 1.00 0.58 ? 74  ILE A CA  1 
ATOM 558  C C   . ILE A 1 74  ? 39.483 45.988 35.255 1.00 0.58 ? 74  ILE A C   1 
ATOM 559  O O   . ILE A 1 74  ? 40.098 45.636 36.261 1.00 0.58 ? 74  ILE A O   1 
ATOM 560  C CB  . ILE A 1 74  ? 37.085 46.047 35.957 1.00 0.58 ? 74  ILE A CB  1 
ATOM 561  C CG1 . ILE A 1 74  ? 35.633 45.577 35.681 1.00 0.58 ? 74  ILE A CG1 1 
ATOM 562  C CG2 . ILE A 1 74  ? 37.175 47.591 35.974 1.00 0.58 ? 74  ILE A CG2 1 
ATOM 563  C CD1 . ILE A 1 74  ? 35.019 46.118 34.385 1.00 0.58 ? 74  ILE A CD1 1 
ATOM 564  N N   . ASN A 1 75  ? 40.040 46.861 34.383 1.00 0.49 ? 75  ASN A N   1 
ATOM 565  C CA  . ASN A 1 75  ? 41.368 47.427 34.545 1.00 0.49 ? 75  ASN A CA  1 
ATOM 566  C C   . ASN A 1 75  ? 41.345 48.843 33.965 1.00 0.49 ? 75  ASN A C   1 
ATOM 567  O O   . ASN A 1 75  ? 40.452 49.182 33.200 1.00 0.49 ? 75  ASN A O   1 
ATOM 568  C CB  . ASN A 1 75  ? 42.463 46.579 33.826 1.00 0.49 ? 75  ASN A CB  1 
ATOM 569  C CG  . ASN A 1 75  ? 42.688 45.235 34.512 1.00 0.49 ? 75  ASN A CG  1 
ATOM 570  O OD1 . ASN A 1 75  ? 42.352 44.166 34.004 1.00 0.49 ? 75  ASN A OD1 1 
ATOM 571  N ND2 . ASN A 1 75  ? 43.310 45.254 35.715 1.00 0.49 ? 75  ASN A ND2 1 
ATOM 572  N N   . THR A 1 76  ? 42.330 49.719 34.301 1.00 0.43 ? 76  THR A N   1 
ATOM 573  C CA  . THR A 1 76  ? 42.313 51.168 33.990 1.00 0.43 ? 76  THR A CA  1 
ATOM 574  C C   . THR A 1 76  ? 42.062 51.544 32.537 1.00 0.43 ? 76  THR A C   1 
ATOM 575  O O   . THR A 1 76  ? 41.391 52.534 32.254 1.00 0.43 ? 76  THR A O   1 
ATOM 576  C CB  . THR A 1 76  ? 43.619 51.869 34.429 1.00 0.43 ? 76  THR A CB  1 
ATOM 577  O OG1 . THR A 1 76  ? 43.702 52.035 35.840 1.00 0.43 ? 76  THR A OG1 1 
ATOM 578  C CG2 . THR A 1 76  ? 43.827 53.299 33.902 1.00 0.43 ? 76  THR A CG2 1 
ATOM 579  N N   . ASN A 1 77  ? 42.595 50.785 31.561 1.00 0.56 ? 77  ASN A N   1 
ATOM 580  C CA  . ASN A 1 77  ? 42.380 51.073 30.157 1.00 0.56 ? 77  ASN A CA  1 
ATOM 581  C C   . ASN A 1 77  ? 41.308 50.213 29.497 1.00 0.56 ? 77  ASN A C   1 
ATOM 582  O O   . ASN A 1 77  ? 41.045 50.390 28.310 1.00 0.56 ? 77  ASN A O   1 
ATOM 583  C CB  . ASN A 1 77  ? 43.699 50.834 29.380 1.00 0.56 ? 77  ASN A CB  1 
ATOM 584  C CG  . ASN A 1 77  ? 44.733 51.875 29.779 1.00 0.56 ? 77  ASN A CG  1 
ATOM 585  O OD1 . ASN A 1 77  ? 45.692 51.640 30.518 1.00 0.56 ? 77  ASN A OD1 1 
ATOM 586  N ND2 . ASN A 1 77  ? 44.539 53.111 29.269 1.00 0.56 ? 77  ASN A ND2 1 
ATOM 587  N N   . SER A 1 78  ? 40.665 49.259 30.209 1.00 0.62 ? 78  SER A N   1 
ATOM 588  C CA  . SER A 1 78  ? 39.747 48.321 29.572 1.00 0.62 ? 78  SER A CA  1 
ATOM 589  C C   . SER A 1 78  ? 38.401 48.896 29.171 1.00 0.62 ? 78  SER A C   1 
ATOM 590  O O   . SER A 1 78  ? 37.912 48.653 28.067 1.00 0.62 ? 78  SER A O   1 
ATOM 591  C CB  . SER A 1 78  ? 39.538 47.003 30.386 1.00 0.62 ? 78  SER A CB  1 
ATOM 592  O OG  . SER A 1 78  ? 38.984 47.198 31.688 1.00 0.62 ? 78  SER A OG  1 
ATOM 593  N N   . SER A 1 79  ? 37.741 49.669 30.050 1.00 0.57 ? 79  SER A N   1 
ATOM 594  C CA  . SER A 1 79  ? 36.328 49.930 29.870 1.00 0.57 ? 79  SER A CA  1 
ATOM 595  C C   . SER A 1 79  ? 35.850 50.999 30.847 1.00 0.57 ? 79  SER A C   1 
ATOM 596  O O   . SER A 1 79  ? 36.559 51.274 31.811 1.00 0.57 ? 79  SER A O   1 
ATOM 597  C CB  . SER A 1 79  ? 35.510 48.611 30.008 1.00 0.57 ? 79  SER A CB  1 
ATOM 598  O OG  . SER A 1 79  ? 35.933 47.805 31.106 1.00 0.57 ? 79  SER A OG  1 
ATOM 599  N N   . PRO A 1 80  ? 34.702 51.667 30.678 1.00 0.39 ? 80  PRO A N   1 
ATOM 600  C CA  . PRO A 1 80  ? 34.330 52.801 31.530 1.00 0.39 ? 80  PRO A CA  1 
ATOM 601  C C   . PRO A 1 80  ? 33.534 52.334 32.746 1.00 0.39 ? 80  PRO A C   1 
ATOM 602  O O   . PRO A 1 80  ? 32.332 52.584 32.812 1.00 0.39 ? 80  PRO A O   1 
ATOM 603  C CB  . PRO A 1 80  ? 33.437 53.647 30.589 1.00 0.39 ? 80  PRO A CB  1 
ATOM 604  C CG  . PRO A 1 80  ? 32.773 52.619 29.668 1.00 0.39 ? 80  PRO A CG  1 
ATOM 605  C CD  . PRO A 1 80  ? 33.867 51.574 29.477 1.00 0.39 ? 80  PRO A CD  1 
ATOM 606  N N   . ASP A 1 81  ? 34.194 51.637 33.697 1.00 0.49 ? 81  ASP A N   1 
ATOM 607  C CA  . ASP A 1 81  ? 33.619 51.060 34.907 1.00 0.49 ? 81  ASP A CA  1 
ATOM 608  C C   . ASP A 1 81  ? 32.443 50.117 34.610 1.00 0.49 ? 81  ASP A C   1 
ATOM 609  O O   . ASP A 1 81  ? 31.436 50.061 35.314 1.00 0.49 ? 81  ASP A O   1 
ATOM 610  C CB  . ASP A 1 81  ? 33.309 52.138 35.987 1.00 0.49 ? 81  ASP A CB  1 
ATOM 611  C CG  . ASP A 1 81  ? 34.545 52.947 36.360 1.00 0.49 ? 81  ASP A CG  1 
ATOM 612  O OD1 . ASP A 1 81  ? 35.682 52.485 36.076 1.00 0.49 ? 81  ASP A OD1 1 
ATOM 613  O OD2 . ASP A 1 81  ? 34.360 54.035 36.964 1.00 0.49 ? 81  ASP A OD2 1 
ATOM 614  N N   . ASP A 1 82  ? 32.585 49.320 33.531 1.00 0.52 ? 82  ASP A N   1 
ATOM 615  C CA  . ASP A 1 82  ? 31.510 48.588 32.908 1.00 0.52 ? 82  ASP A CA  1 
ATOM 616  C C   . ASP A 1 82  ? 32.164 47.463 32.106 1.00 0.52 ? 82  ASP A C   1 
ATOM 617  O O   . ASP A 1 82  ? 33.384 47.458 31.933 1.00 0.52 ? 82  ASP A O   1 
ATOM 618  C CB  . ASP A 1 82  ? 30.706 49.551 31.993 1.00 0.52 ? 82  ASP A CB  1 
ATOM 619  C CG  . ASP A 1 82  ? 29.429 48.930 31.474 1.00 0.52 ? 82  ASP A CG  1 
ATOM 620  O OD1 . ASP A 1 82  ? 29.076 47.803 31.911 1.00 0.52 ? 82  ASP A OD1 1 
ATOM 621  O OD2 . ASP A 1 82  ? 28.767 49.573 30.629 1.00 0.52 ? 82  ASP A OD2 1 
ATOM 622  N N   . GLN A 1 83  ? 31.416 46.469 31.591 1.00 0.62 ? 83  GLN A N   1 
ATOM 623  C CA  . GLN A 1 83  ? 32.025 45.440 30.771 1.00 0.62 ? 83  GLN A CA  1 
ATOM 624  C C   . GLN A 1 83  ? 31.067 44.740 29.816 1.00 0.62 ? 83  GLN A C   1 
ATOM 625  O O   . GLN A 1 83  ? 30.102 44.118 30.243 1.00 0.62 ? 83  GLN A O   1 
ATOM 626  C CB  . GLN A 1 83  ? 32.727 44.368 31.651 1.00 0.62 ? 83  GLN A CB  1 
ATOM 627  C CG  . GLN A 1 83  ? 33.636 43.374 30.897 1.00 0.62 ? 83  GLN A CG  1 
ATOM 628  C CD  . GLN A 1 83  ? 34.744 44.097 30.137 1.00 0.62 ? 83  GLN A CD  1 
ATOM 629  O OE1 . GLN A 1 83  ? 34.530 44.646 29.050 1.00 0.62 ? 83  GLN A OE1 1 
ATOM 630  N NE2 . GLN A 1 83  ? 35.969 44.117 30.707 1.00 0.62 ? 83  GLN A NE2 1 
ATOM 631  N N   . ILE A 1 84  ? 31.348 44.783 28.487 1.00 0.60 ? 84  ILE A N   1 
ATOM 632  C CA  . ILE A 1 84  ? 30.631 43.974 27.501 1.00 0.60 ? 84  ILE A CA  1 
ATOM 633  C C   . ILE A 1 84  ? 31.586 43.050 26.751 1.00 0.60 ? 84  ILE A C   1 
ATOM 634  O O   . ILE A 1 84  ? 31.219 42.404 25.767 1.00 0.60 ? 84  ILE A O   1 
ATOM 635  C CB  . ILE A 1 84  ? 29.760 44.788 26.527 1.00 0.60 ? 84  ILE A CB  1 
ATOM 636  C CG1 . ILE A 1 84  ? 30.562 45.638 25.511 1.00 0.60 ? 84  ILE A CG1 1 
ATOM 637  C CG2 . ILE A 1 84  ? 28.779 45.636 27.368 1.00 0.60 ? 84  ILE A CG2 1 
ATOM 638  C CD1 . ILE A 1 84  ? 29.688 46.430 24.524 1.00 0.60 ? 84  ILE A CD1 1 
ATOM 639  N N   . GLY A 1 85  ? 32.853 42.950 27.218 1.00 0.64 ? 85  GLY A N   1 
ATOM 640  C CA  . GLY A 1 85  ? 33.821 41.956 26.774 1.00 0.64 ? 85  GLY A CA  1 
ATOM 641  C C   . GLY A 1 85  ? 33.753 40.695 27.588 1.00 0.64 ? 85  GLY A C   1 
ATOM 642  O O   . GLY A 1 85  ? 33.597 40.730 28.803 1.00 0.64 ? 85  GLY A O   1 
ATOM 643  N N   . TYR A 1 86  ? 33.905 39.533 26.933 1.00 0.61 ? 86  TYR A N   1 
ATOM 644  C CA  . TYR A 1 86  ? 33.730 38.235 27.550 1.00 0.61 ? 86  TYR A CA  1 
ATOM 645  C C   . TYR A 1 86  ? 34.813 37.293 27.069 1.00 0.61 ? 86  TYR A C   1 
ATOM 646  O O   . TYR A 1 86  ? 35.380 37.459 25.989 1.00 0.61 ? 86  TYR A O   1 
ATOM 647  C CB  . TYR A 1 86  ? 32.384 37.587 27.135 1.00 0.61 ? 86  TYR A CB  1 
ATOM 648  C CG  . TYR A 1 86  ? 31.220 38.278 27.779 1.00 0.61 ? 86  TYR A CG  1 
ATOM 649  C CD1 . TYR A 1 86  ? 30.691 39.452 27.227 1.00 0.61 ? 86  TYR A CD1 1 
ATOM 650  C CD2 . TYR A 1 86  ? 30.623 37.748 28.931 1.00 0.61 ? 86  TYR A CD2 1 
ATOM 651  C CE1 . TYR A 1 86  ? 29.600 40.092 27.822 1.00 0.61 ? 86  TYR A CE1 1 
ATOM 652  C CE2 . TYR A 1 86  ? 29.490 38.356 29.494 1.00 0.61 ? 86  TYR A CE2 1 
ATOM 653  C CZ  . TYR A 1 86  ? 28.979 39.536 28.940 1.00 0.61 ? 86  TYR A CZ  1 
ATOM 654  O OH  . TYR A 1 86  ? 27.837 40.196 29.435 1.00 0.61 ? 86  TYR A OH  1 
ATOM 655  N N   . TYR A 1 87  ? 35.129 36.257 27.874 1.00 0.64 ? 87  TYR A N   1 
ATOM 656  C CA  . TYR A 1 87  ? 36.048 35.197 27.497 1.00 0.64 ? 87  TYR A CA  1 
ATOM 657  C C   . TYR A 1 87  ? 35.567 34.376 26.299 1.00 0.64 ? 87  TYR A C   1 
ATOM 658  O O   . TYR A 1 87  ? 34.402 33.980 26.209 1.00 0.64 ? 87  TYR A O   1 
ATOM 659  C CB  . TYR A 1 87  ? 36.319 34.214 28.664 1.00 0.64 ? 87  TYR A CB  1 
ATOM 660  C CG  . TYR A 1 87  ? 36.923 34.873 29.874 1.00 0.64 ? 87  TYR A CG  1 
ATOM 661  C CD1 . TYR A 1 87  ? 38.316 34.917 30.051 1.00 0.64 ? 87  TYR A CD1 1 
ATOM 662  C CD2 . TYR A 1 87  ? 36.094 35.323 30.917 1.00 0.64 ? 87  TYR A CD2 1 
ATOM 663  C CE1 . TYR A 1 87  ? 38.865 35.386 31.257 1.00 0.64 ? 87  TYR A CE1 1 
ATOM 664  C CE2 . TYR A 1 87  ? 36.640 35.800 32.111 1.00 0.64 ? 87  TYR A CE2 1 
ATOM 665  C CZ  . TYR A 1 87  ? 38.023 35.825 32.279 1.00 0.64 ? 87  TYR A CZ  1 
ATOM 666  O OH  . TYR A 1 87  ? 38.554 36.257 33.500 1.00 0.64 ? 87  TYR A OH  1 
ATOM 667  N N   . ARG A 1 88  ? 36.489 34.086 25.361 1.00 0.61 ? 88  ARG A N   1 
ATOM 668  C CA  . ARG A 1 88  ? 36.254 33.285 24.178 1.00 0.61 ? 88  ARG A CA  1 
ATOM 669  C C   . ARG A 1 88  ? 37.245 32.138 24.155 1.00 0.61 ? 88  ARG A C   1 
ATOM 670  O O   . ARG A 1 88  ? 38.456 32.349 24.142 1.00 0.61 ? 88  ARG A O   1 
ATOM 671  C CB  . ARG A 1 88  ? 36.473 34.152 22.898 1.00 0.61 ? 88  ARG A CB  1 
ATOM 672  C CG  . ARG A 1 88  ? 36.568 33.395 21.550 1.00 0.61 ? 88  ARG A CG  1 
ATOM 673  C CD  . ARG A 1 88  ? 36.889 34.284 20.328 1.00 0.61 ? 88  ARG A CD  1 
ATOM 674  N NE  . ARG A 1 88  ? 35.602 34.773 19.737 1.00 0.61 ? 88  ARG A NE  1 
ATOM 675  C CZ  . ARG A 1 88  ? 35.530 35.712 18.780 1.00 0.61 ? 88  ARG A CZ  1 
ATOM 676  N NH1 . ARG A 1 88  ? 34.400 35.876 18.097 1.00 0.61 ? 88  ARG A NH1 1 
ATOM 677  N NH2 . ARG A 1 88  ? 36.551 36.502 18.481 1.00 0.61 ? 88  ARG A NH2 1 
ATOM 678  N N   . ARG A 1 89  ? 36.756 30.883 24.110 1.00 0.57 ? 89  ARG A N   1 
ATOM 679  C CA  . ARG A 1 89  ? 37.584 29.723 23.812 1.00 0.57 ? 89  ARG A CA  1 
ATOM 680  C C   . ARG A 1 89  ? 37.843 29.683 22.314 1.00 0.57 ? 89  ARG A C   1 
ATOM 681  O O   . ARG A 1 89  ? 36.894 29.624 21.536 1.00 0.57 ? 89  ARG A O   1 
ATOM 682  C CB  . ARG A 1 89  ? 36.862 28.419 24.232 1.00 0.57 ? 89  ARG A CB  1 
ATOM 683  C CG  . ARG A 1 89  ? 37.672 27.118 24.041 1.00 0.57 ? 89  ARG A CG  1 
ATOM 684  C CD  . ARG A 1 89  ? 36.952 25.907 24.651 1.00 0.57 ? 89  ARG A CD  1 
ATOM 685  N NE  . ARG A 1 89  ? 37.804 24.692 24.429 1.00 0.57 ? 89  ARG A NE  1 
ATOM 686  C CZ  . ARG A 1 89  ? 37.564 23.498 24.990 1.00 0.57 ? 89  ARG A CZ  1 
ATOM 687  N NH1 . ARG A 1 89  ? 38.352 22.461 24.710 1.00 0.57 ? 89  ARG A NH1 1 
ATOM 688  N NH2 . ARG A 1 89  ? 36.548 23.320 25.828 1.00 0.57 ? 89  ARG A NH2 1 
ATOM 689  N N   . ALA A 1 90  ? 39.113 29.741 21.870 1.00 0.54 ? 90  ALA A N   1 
ATOM 690  C CA  . ALA A 1 90  ? 39.441 29.934 20.472 1.00 0.54 ? 90  ALA A CA  1 
ATOM 691  C C   . ALA A 1 90  ? 39.874 28.632 19.801 1.00 0.54 ? 90  ALA A C   1 
ATOM 692  O O   . ALA A 1 90  ? 40.695 27.879 20.321 1.00 0.54 ? 90  ALA A O   1 
ATOM 693  C CB  . ALA A 1 90  ? 40.574 30.983 20.378 1.00 0.54 ? 90  ALA A CB  1 
ATOM 694  N N   . THR A 1 91  ? 39.366 28.338 18.583 1.00 0.39 ? 91  THR A N   1 
ATOM 695  C CA  . THR A 1 91  ? 39.658 27.090 17.870 1.00 0.39 ? 91  THR A CA  1 
ATOM 696  C C   . THR A 1 91  ? 40.893 27.221 17.008 1.00 0.39 ? 91  THR A C   1 
ATOM 697  O O   . THR A 1 91  ? 41.320 26.295 16.322 1.00 0.39 ? 91  THR A O   1 
ATOM 698  C CB  . THR A 1 91  ? 38.536 26.609 16.939 1.00 0.39 ? 91  THR A CB  1 
ATOM 699  O OG1 . THR A 1 91  ? 38.239 27.504 15.876 1.00 0.39 ? 91  THR A OG1 1 
ATOM 700  C CG2 . THR A 1 91  ? 37.252 26.403 17.756 1.00 0.39 ? 91  THR A CG2 1 
ATOM 701  N N   . ARG A 1 92  ? 41.528 28.408 17.032 1.00 0.32 ? 92  ARG A N   1 
ATOM 702  C CA  . ARG A 1 92  ? 42.597 28.761 16.130 1.00 0.32 ? 92  ARG A CA  1 
ATOM 703  C C   . ARG A 1 92  ? 43.889 27.960 16.219 1.00 0.32 ? 92  ARG A C   1 
ATOM 704  O O   . ARG A 1 92  ? 44.463 27.630 15.174 1.00 0.32 ? 92  ARG A O   1 
ATOM 705  C CB  . ARG A 1 92  ? 42.958 30.257 16.299 1.00 0.32 ? 92  ARG A CB  1 
ATOM 706  C CG  . ARG A 1 92  ? 44.055 30.838 15.368 1.00 0.32 ? 92  ARG A CG  1 
ATOM 707  C CD  . ARG A 1 92  ? 43.695 30.912 13.873 1.00 0.32 ? 92  ARG A CD  1 
ATOM 708  N NE  . ARG A 1 92  ? 43.921 29.563 13.261 1.00 0.32 ? 92  ARG A NE  1 
ATOM 709  C CZ  . ARG A 1 92  ? 43.625 29.242 11.994 1.00 0.32 ? 92  ARG A CZ  1 
ATOM 710  N NH1 . ARG A 1 92  ? 43.813 27.994 11.576 1.00 0.32 ? 92  ARG A NH1 1 
ATOM 711  N NH2 . ARG A 1 92  ? 43.132 30.146 11.153 1.00 0.32 ? 92  ARG A NH2 1 
ATOM 712  N N   . ARG A 1 93  ? 44.420 27.687 17.432 1.00 0.41 ? 93  ARG A N   1 
ATOM 713  C CA  . ARG A 1 93  ? 45.679 26.981 17.559 1.00 0.41 ? 93  ARG A CA  1 
ATOM 714  C C   . ARG A 1 93  ? 45.970 26.459 18.958 1.00 0.41 ? 93  ARG A C   1 
ATOM 715  O O   . ARG A 1 93  ? 45.550 27.044 19.960 1.00 0.41 ? 93  ARG A O   1 
ATOM 716  C CB  . ARG A 1 93  ? 46.898 27.865 17.154 1.00 0.41 ? 93  ARG A CB  1 
ATOM 717  C CG  . ARG A 1 93  ? 47.107 29.132 18.016 1.00 0.41 ? 93  ARG A CG  1 
ATOM 718  C CD  . ARG A 1 93  ? 48.371 29.938 17.682 1.00 0.41 ? 93  ARG A CD  1 
ATOM 719  N NE  . ARG A 1 93  ? 48.181 30.634 16.361 1.00 0.41 ? 93  ARG A NE  1 
ATOM 720  C CZ  . ARG A 1 93  ? 48.745 30.275 15.196 1.00 0.41 ? 93  ARG A CZ  1 
ATOM 721  N NH1 . ARG A 1 93  ? 48.520 31.012 14.108 1.00 0.41 ? 93  ARG A NH1 1 
ATOM 722  N NH2 . ARG A 1 93  ? 49.526 29.207 15.087 1.00 0.41 ? 93  ARG A NH2 1 
ATOM 723  N N   . ILE A 1 94  ? 46.796 25.393 19.030 1.00 0.42 ? 94  ILE A N   1 
ATOM 724  C CA  . ILE A 1 94  ? 47.542 24.973 20.210 1.00 0.42 ? 94  ILE A CA  1 
ATOM 725  C C   . ILE A 1 94  ? 48.981 25.383 19.924 1.00 0.42 ? 94  ILE A C   1 
ATOM 726  O O   . ILE A 1 94  ? 49.454 25.248 18.797 1.00 0.42 ? 94  ILE A O   1 
ATOM 727  C CB  . ILE A 1 94  ? 47.453 23.461 20.465 1.00 0.42 ? 94  ILE A CB  1 
ATOM 728  C CG1 . ILE A 1 94  ? 45.993 23.049 20.769 1.00 0.42 ? 94  ILE A CG1 1 
ATOM 729  C CG2 . ILE A 1 94  ? 48.376 23.042 21.638 1.00 0.42 ? 94  ILE A CG2 1 
ATOM 730  C CD1 . ILE A 1 94  ? 45.737 21.537 20.722 1.00 0.42 ? 94  ILE A CD1 1 
ATOM 731  N N   . ARG A 1 95  ? 49.704 25.965 20.908 1.00 0.39 ? 95  ARG A N   1 
ATOM 732  C CA  . ARG A 1 95  ? 51.097 26.348 20.739 1.00 0.39 ? 95  ARG A CA  1 
ATOM 733  C C   . ARG A 1 95  ? 51.910 25.832 21.915 1.00 0.39 ? 95  ARG A C   1 
ATOM 734  O O   . ARG A 1 95  ? 51.460 25.890 23.057 1.00 0.39 ? 95  ARG A O   1 
ATOM 735  C CB  . ARG A 1 95  ? 51.247 27.890 20.620 1.00 0.39 ? 95  ARG A CB  1 
ATOM 736  C CG  . ARG A 1 95  ? 52.676 28.401 20.326 1.00 0.39 ? 95  ARG A CG  1 
ATOM 737  C CD  . ARG A 1 95  ? 52.734 29.909 20.045 1.00 0.39 ? 95  ARG A CD  1 
ATOM 738  N NE  . ARG A 1 95  ? 54.170 30.281 19.815 1.00 0.39 ? 95  ARG A NE  1 
ATOM 739  C CZ  . ARG A 1 95  ? 54.600 31.518 19.525 1.00 0.39 ? 95  ARG A CZ  1 
ATOM 740  N NH1 . ARG A 1 95  ? 55.899 31.747 19.346 1.00 0.39 ? 95  ARG A NH1 1 
ATOM 741  N NH2 . ARG A 1 95  ? 53.747 32.525 19.380 1.00 0.39 ? 95  ARG A NH2 1 
ATOM 742  N N   . GLY A 1 96  ? 53.138 25.324 21.654 1.00 0.45 ? 96  GLY A N   1 
ATOM 743  C CA  . GLY A 1 96  ? 53.943 24.600 22.637 1.00 0.45 ? 96  GLY A CA  1 
ATOM 744  C C   . GLY A 1 96  ? 53.410 23.230 22.979 1.00 0.45 ? 96  GLY A C   1 
ATOM 745  O O   . GLY A 1 96  ? 52.506 22.725 22.321 1.00 0.45 ? 96  GLY A O   1 
ATOM 746  N N   . GLY A 1 97  ? 54.003 22.567 23.991 1.00 0.44 ? 97  GLY A N   1 
ATOM 747  C CA  . GLY A 1 97  ? 53.568 21.243 24.428 1.00 0.44 ? 97  GLY A CA  1 
ATOM 748  C C   . GLY A 1 97  ? 53.670 21.058 25.917 1.00 0.44 ? 97  GLY A C   1 
ATOM 749  O O   . GLY A 1 97  ? 54.472 21.711 26.575 1.00 0.44 ? 97  GLY A O   1 
ATOM 750  N N   . ASP A 1 98  ? 52.859 20.146 26.490 1.00 0.39 ? 98  ASP A N   1 
ATOM 751  C CA  . ASP A 1 98  ? 52.883 19.840 27.898 1.00 0.39 ? 98  ASP A CA  1 
ATOM 752  C C   . ASP A 1 98  ? 52.459 18.386 28.038 1.00 0.39 ? 98  ASP A C   1 
ATOM 753  O O   . ASP A 1 98  ? 51.714 17.882 27.195 1.00 0.39 ? 98  ASP A O   1 
ATOM 754  C CB  . ASP A 1 98  ? 51.934 20.782 28.682 1.00 0.39 ? 98  ASP A CB  1 
ATOM 755  C CG  . ASP A 1 98  ? 52.114 20.604 30.181 1.00 0.39 ? 98  ASP A CG  1 
ATOM 756  O OD1 . ASP A 1 98  ? 53.239 20.200 30.596 1.00 0.39 ? 98  ASP A OD1 1 
ATOM 757  O OD2 . ASP A 1 98  ? 51.169 20.895 30.942 1.00 0.39 ? 98  ASP A OD2 1 
ATOM 758  N N   . GLY A 1 99  ? 52.944 17.686 29.093 1.00 0.41 ? 99  GLY A N   1 
ATOM 759  C CA  . GLY A 1 99  ? 52.619 16.294 29.419 1.00 0.41 ? 99  GLY A CA  1 
ATOM 760  C C   . GLY A 1 99  ? 52.579 15.305 28.277 1.00 0.41 ? 99  GLY A C   1 
ATOM 761  O O   . GLY A 1 99  ? 53.458 15.223 27.422 1.00 0.41 ? 99  GLY A O   1 
ATOM 762  N N   . LYS A 1 100 ? 51.518 14.477 28.234 1.00 0.35 ? 100 LYS A N   1 
ATOM 763  C CA  . LYS A 1 100 ? 51.123 13.843 26.992 1.00 0.35 ? 100 LYS A CA  1 
ATOM 764  C C   . LYS A 1 100 ? 50.510 14.884 26.067 1.00 0.35 ? 100 LYS A C   1 
ATOM 765  O O   . LYS A 1 100 ? 49.583 15.582 26.458 1.00 0.35 ? 100 LYS A O   1 
ATOM 766  C CB  . LYS A 1 100 ? 50.090 12.720 27.236 1.00 0.35 ? 100 LYS A CB  1 
ATOM 767  C CG  . LYS A 1 100 ? 50.667 11.539 28.027 1.00 0.35 ? 100 LYS A CG  1 
ATOM 768  C CD  . LYS A 1 100 ? 49.623 10.429 28.240 1.00 0.35 ? 100 LYS A CD  1 
ATOM 769  C CE  . LYS A 1 100 ? 50.159 9.178  28.944 1.00 0.35 ? 100 LYS A CE  1 
ATOM 770  N NZ  . LYS A 1 100 ? 50.479 9.482  30.355 1.00 0.35 ? 100 LYS A NZ  1 
ATOM 771  N N   . MET A 1 101 ? 50.996 14.992 24.811 1.00 0.30 ? 101 MET A N   1 
ATOM 772  C CA  . MET A 1 101 ? 50.821 16.162 23.952 1.00 0.30 ? 101 MET A CA  1 
ATOM 773  C C   . MET A 1 101 ? 49.388 16.620 23.697 1.00 0.30 ? 101 MET A C   1 
ATOM 774  O O   . MET A 1 101 ? 49.101 17.804 23.552 1.00 0.30 ? 101 MET A O   1 
ATOM 775  C CB  . MET A 1 101 ? 51.550 15.905 22.603 1.00 0.30 ? 101 MET A CB  1 
ATOM 776  C CG  . MET A 1 101 ? 51.697 17.137 21.685 1.00 0.30 ? 101 MET A CG  1 
ATOM 777  S SD  . MET A 1 101 ? 52.720 18.448 22.411 1.00 0.30 ? 101 MET A SD  1 
ATOM 778  C CE  . MET A 1 101 ? 52.630 19.554 20.976 1.00 0.30 ? 101 MET A CE  1 
ATOM 779  N N   . LYS A 1 102 ? 48.440 15.667 23.667 1.00 0.42 ? 102 LYS A N   1 
ATOM 780  C CA  . LYS A 1 102 ? 47.023 15.904 23.488 1.00 0.42 ? 102 LYS A CA  1 
ATOM 781  C C   . LYS A 1 102 ? 46.335 16.651 24.642 1.00 0.42 ? 102 LYS A C   1 
ATOM 782  O O   . LYS A 1 102 ? 45.268 17.228 24.449 1.00 0.42 ? 102 LYS A O   1 
ATOM 783  C CB  . LYS A 1 102 ? 46.352 14.520 23.282 1.00 0.42 ? 102 LYS A CB  1 
ATOM 784  C CG  . LYS A 1 102 ? 44.895 14.581 22.796 1.00 0.42 ? 102 LYS A CG  1 
ATOM 785  C CD  . LYS A 1 102 ? 44.316 13.196 22.467 1.00 0.42 ? 102 LYS A CD  1 
ATOM 786  C CE  . LYS A 1 102 ? 42.867 13.273 21.976 1.00 0.42 ? 102 LYS A CE  1 
ATOM 787  N NZ  . LYS A 1 102 ? 42.348 11.923 21.660 1.00 0.42 ? 102 LYS A NZ  1 
ATOM 788  N N   . ASP A 1 103 ? 46.922 16.651 25.863 1.00 0.34 ? 103 ASP A N   1 
ATOM 789  C CA  . ASP A 1 103 ? 46.339 17.233 27.060 1.00 0.34 ? 103 ASP A CA  1 
ATOM 790  C C   . ASP A 1 103 ? 46.483 18.761 27.091 1.00 0.34 ? 103 ASP A C   1 
ATOM 791  O O   . ASP A 1 103 ? 45.735 19.484 27.749 1.00 0.34 ? 103 ASP A O   1 
ATOM 792  C CB  . ASP A 1 103 ? 47.032 16.537 28.262 1.00 0.34 ? 103 ASP A CB  1 
ATOM 793  C CG  . ASP A 1 103 ? 46.224 16.588 29.551 1.00 0.34 ? 103 ASP A CG  1 
ATOM 794  O OD1 . ASP A 1 103 ? 44.970 16.521 29.470 1.00 0.34 ? 103 ASP A OD1 1 
ATOM 795  O OD2 . ASP A 1 103 ? 46.872 16.574 30.630 1.00 0.34 ? 103 ASP A OD2 1 
ATOM 796  N N   . LEU A 1 104 ? 47.428 19.329 26.308 1.00 0.46 ? 104 LEU A N   1 
ATOM 797  C CA  . LEU A 1 104 ? 47.559 20.773 26.236 1.00 0.46 ? 104 LEU A CA  1 
ATOM 798  C C   . LEU A 1 104 ? 46.445 21.425 25.424 1.00 0.46 ? 104 LEU A C   1 
ATOM 799  O O   . LEU A 1 104 ? 46.315 21.263 24.211 1.00 0.46 ? 104 LEU A O   1 
ATOM 800  C CB  . LEU A 1 104 ? 48.941 21.227 25.715 1.00 0.46 ? 104 LEU A CB  1 
ATOM 801  C CG  . LEU A 1 104 ? 49.174 22.759 25.726 1.00 0.46 ? 104 LEU A CG  1 
ATOM 802  C CD1 . LEU A 1 104 ? 49.031 23.389 27.122 1.00 0.46 ? 104 LEU A CD1 1 
ATOM 803  C CD2 . LEU A 1 104 ? 50.557 23.086 25.153 1.00 0.46 ? 104 LEU A CD2 1 
ATOM 804  N N   . SER A 1 105 ? 45.590 22.195 26.122 1.00 0.55 ? 105 SER A N   1 
ATOM 805  C CA  . SER A 1 105 ? 44.463 22.931 25.575 1.00 0.55 ? 105 SER A CA  1 
ATOM 806  C C   . SER A 1 105 ? 44.797 24.006 24.542 1.00 0.55 ? 105 SER A C   1 
ATOM 807  O O   . SER A 1 105 ? 45.871 24.603 24.618 1.00 0.55 ? 105 SER A O   1 
ATOM 808  C CB  . SER A 1 105 ? 43.640 23.630 26.692 1.00 0.55 ? 105 SER A CB  1 
ATOM 809  O OG  . SER A 1 105 ? 43.581 22.843 27.879 1.00 0.55 ? 105 SER A OG  1 
ATOM 810  N N   . PRO A 1 106 ? 43.937 24.335 23.567 1.00 0.55 ? 106 PRO A N   1 
ATOM 811  C CA  . PRO A 1 106 ? 44.107 25.531 22.743 1.00 0.55 ? 106 PRO A CA  1 
ATOM 812  C C   . PRO A 1 106 ? 44.017 26.834 23.524 1.00 0.55 ? 106 PRO A C   1 
ATOM 813  O O   . PRO A 1 106 ? 43.758 26.828 24.726 1.00 0.55 ? 106 PRO A O   1 
ATOM 814  C CB  . PRO A 1 106 ? 42.990 25.412 21.698 1.00 0.55 ? 106 PRO A CB  1 
ATOM 815  C CG  . PRO A 1 106 ? 41.872 24.686 22.440 1.00 0.55 ? 106 PRO A CG  1 
ATOM 816  C CD  . PRO A 1 106 ? 42.641 23.695 23.317 1.00 0.55 ? 106 PRO A CD  1 
ATOM 817  N N   . ARG A 1 107 ? 44.261 27.963 22.842 1.00 0.55 ? 107 ARG A N   1 
ATOM 818  C CA  . ARG A 1 107 ? 44.174 29.297 23.406 1.00 0.55 ? 107 ARG A CA  1 
ATOM 819  C C   . ARG A 1 107 ? 42.771 29.809 23.729 1.00 0.55 ? 107 ARG A C   1 
ATOM 820  O O   . ARG A 1 107 ? 41.766 29.446 23.120 1.00 0.55 ? 107 ARG A O   1 
ATOM 821  C CB  . ARG A 1 107 ? 44.835 30.336 22.474 1.00 0.55 ? 107 ARG A CB  1 
ATOM 822  C CG  . ARG A 1 107 ? 46.373 30.294 22.478 1.00 0.55 ? 107 ARG A CG  1 
ATOM 823  C CD  . ARG A 1 107 ? 46.926 31.420 21.611 1.00 0.55 ? 107 ARG A CD  1 
ATOM 824  N NE  . ARG A 1 107 ? 48.404 31.524 21.802 1.00 0.55 ? 107 ARG A NE  1 
ATOM 825  C CZ  . ARG A 1 107 ? 49.097 32.599 21.403 1.00 0.55 ? 107 ARG A CZ  1 
ATOM 826  N NH1 . ARG A 1 107 ? 50.376 32.723 21.759 1.00 0.55 ? 107 ARG A NH1 1 
ATOM 827  N NH2 . ARG A 1 107 ? 48.532 33.572 20.695 1.00 0.55 ? 107 ARG A NH2 1 
ATOM 828  N N   . TRP A 1 108 ? 42.701 30.731 24.702 1.00 0.52 ? 108 TRP A N   1 
ATOM 829  C CA  . TRP A 1 108 ? 41.543 31.531 25.026 1.00 0.52 ? 108 TRP A CA  1 
ATOM 830  C C   . TRP A 1 108 ? 41.891 32.999 24.818 1.00 0.52 ? 108 TRP A C   1 
ATOM 831  O O   . TRP A 1 108 ? 43.018 33.438 25.050 1.00 0.52 ? 108 TRP A O   1 
ATOM 832  C CB  . TRP A 1 108 ? 41.127 31.349 26.506 1.00 0.52 ? 108 TRP A CB  1 
ATOM 833  C CG  . TRP A 1 108 ? 40.107 30.281 26.838 1.00 0.52 ? 108 TRP A CG  1 
ATOM 834  C CD1 . TRP A 1 108 ? 38.868 30.509 27.360 1.00 0.52 ? 108 TRP A CD1 1 
ATOM 835  C CD2 . TRP A 1 108 ? 40.255 28.848 26.774 1.00 0.52 ? 108 TRP A CD2 1 
ATOM 836  N NE1 . TRP A 1 108 ? 38.233 29.322 27.627 1.00 0.52 ? 108 TRP A NE1 1 
ATOM 837  C CE2 . TRP A 1 108 ? 39.058 28.294 27.265 1.00 0.52 ? 108 TRP A CE2 1 
ATOM 838  C CE3 . TRP A 1 108 ? 41.293 28.027 26.351 1.00 0.52 ? 108 TRP A CE3 1 
ATOM 839  C CZ2 . TRP A 1 108 ? 38.877 26.923 27.324 1.00 0.52 ? 108 TRP A CZ2 1 
ATOM 840  C CZ3 . TRP A 1 108 ? 41.083 26.638 26.351 1.00 0.52 ? 108 TRP A CZ3 1 
ATOM 841  C CH2 . TRP A 1 108 ? 39.889 26.091 26.827 1.00 0.52 ? 108 TRP A CH2 1 
ATOM 842  N N   . TYR A 1 109 ? 40.894 33.795 24.382 1.00 0.62 ? 109 TYR A N   1 
ATOM 843  C CA  . TYR A 1 109 ? 41.014 35.209 24.064 1.00 0.62 ? 109 TYR A CA  1 
ATOM 844  C C   . TYR A 1 109 ? 39.779 35.930 24.606 1.00 0.62 ? 109 TYR A C   1 
ATOM 845  O O   . TYR A 1 109 ? 38.939 35.326 25.267 1.00 0.62 ? 109 TYR A O   1 
ATOM 846  C CB  . TYR A 1 109 ? 41.084 35.460 22.529 1.00 0.62 ? 109 TYR A CB  1 
ATOM 847  C CG  . TYR A 1 109 ? 42.306 34.892 21.855 1.00 0.62 ? 109 TYR A CG  1 
ATOM 848  C CD1 . TYR A 1 109 ? 43.602 35.078 22.364 1.00 0.62 ? 109 TYR A CD1 1 
ATOM 849  C CD2 . TYR A 1 109 ? 42.163 34.250 20.613 1.00 0.62 ? 109 TYR A CD2 1 
ATOM 850  C CE1 . TYR A 1 109 ? 44.725 34.616 21.660 1.00 0.62 ? 109 TYR A CE1 1 
ATOM 851  C CE2 . TYR A 1 109 ? 43.280 33.791 19.906 1.00 0.62 ? 109 TYR A CE2 1 
ATOM 852  C CZ  . TYR A 1 109 ? 44.563 33.970 20.429 1.00 0.62 ? 109 TYR A CZ  1 
ATOM 853  O OH  . TYR A 1 109 ? 45.672 33.532 19.675 1.00 0.62 ? 109 TYR A OH  1 
ATOM 854  N N   . PHE A 1 110 ? 39.632 37.251 24.348 1.00 0.62 ? 110 PHE A N   1 
ATOM 855  C CA  . PHE A 1 110 ? 38.466 38.035 24.746 1.00 0.62 ? 110 PHE A CA  1 
ATOM 856  C C   . PHE A 1 110 ? 37.728 38.543 23.507 1.00 0.62 ? 110 PHE A C   1 
ATOM 857  O O   . PHE A 1 110 ? 38.336 38.809 22.473 1.00 0.62 ? 110 PHE A O   1 
ATOM 858  C CB  . PHE A 1 110 ? 38.835 39.252 25.637 1.00 0.62 ? 110 PHE A CB  1 
ATOM 859  C CG  . PHE A 1 110 ? 39.261 38.812 27.009 1.00 0.62 ? 110 PHE A CG  1 
ATOM 860  C CD1 . PHE A 1 110 ? 38.309 38.660 28.029 1.00 0.62 ? 110 PHE A CD1 1 
ATOM 861  C CD2 . PHE A 1 110 ? 40.613 38.573 27.306 1.00 0.62 ? 110 PHE A CD2 1 
ATOM 862  C CE1 . PHE A 1 110 ? 38.700 38.301 29.322 1.00 0.62 ? 110 PHE A CE1 1 
ATOM 863  C CE2 . PHE A 1 110 ? 41.008 38.206 28.598 1.00 0.62 ? 110 PHE A CE2 1 
ATOM 864  C CZ  . PHE A 1 110 ? 40.051 38.081 29.611 1.00 0.62 ? 110 PHE A CZ  1 
ATOM 865  N N   . TYR A 1 111 ? 36.387 38.667 23.592 1.00 0.58 ? 111 TYR A N   1 
ATOM 866  C CA  . TYR A 1 111 ? 35.519 39.118 22.514 1.00 0.58 ? 111 TYR A CA  1 
ATOM 867  C C   . TYR A 1 111 ? 34.465 40.059 23.098 1.00 0.58 ? 111 TYR A C   1 
ATOM 868  O O   . TYR A 1 111 ? 33.940 39.813 24.181 1.00 0.58 ? 111 TYR A O   1 
ATOM 869  C CB  . TYR A 1 111 ? 34.860 37.882 21.823 1.00 0.58 ? 111 TYR A CB  1 
ATOM 870  C CG  . TYR A 1 111 ? 33.675 38.195 20.934 1.00 0.58 ? 111 TYR A CG  1 
ATOM 871  C CD1 . TYR A 1 111 ? 33.826 38.663 19.618 1.00 0.58 ? 111 TYR A CD1 1 
ATOM 872  C CD2 . TYR A 1 111 ? 32.379 38.053 21.454 1.00 0.58 ? 111 TYR A CD2 1 
ATOM 873  C CE1 . TYR A 1 111 ? 32.699 38.973 18.840 1.00 0.58 ? 111 TYR A CE1 1 
ATOM 874  C CE2 . TYR A 1 111 ? 31.260 38.369 20.681 1.00 0.58 ? 111 TYR A CE2 1 
ATOM 875  C CZ  . TYR A 1 111 ? 31.417 38.857 19.390 1.00 0.58 ? 111 TYR A CZ  1 
ATOM 876  O OH  . TYR A 1 111 ? 30.263 39.232 18.688 1.00 0.58 ? 111 TYR A OH  1 
ATOM 877  N N   . TYR A 1 112 ? 34.135 41.158 22.382 1.00 0.60 ? 112 TYR A N   1 
ATOM 878  C CA  . TYR A 1 112 ? 33.169 42.165 22.794 1.00 0.60 ? 112 TYR A CA  1 
ATOM 879  C C   . TYR A 1 112 ? 31.890 41.958 22.005 1.00 0.60 ? 112 TYR A C   1 
ATOM 880  O O   . TYR A 1 112 ? 31.911 41.876 20.782 1.00 0.60 ? 112 TYR A O   1 
ATOM 881  C CB  . TYR A 1 112 ? 33.707 43.609 22.568 1.00 0.60 ? 112 TYR A CB  1 
ATOM 882  C CG  . TYR A 1 112 ? 34.582 44.026 23.723 1.00 0.60 ? 112 TYR A CG  1 
ATOM 883  C CD1 . TYR A 1 112 ? 35.814 43.403 23.983 1.00 0.60 ? 112 TYR A CD1 1 
ATOM 884  C CD2 . TYR A 1 112 ? 34.136 45.025 24.602 1.00 0.60 ? 112 TYR A CD2 1 
ATOM 885  C CE1 . TYR A 1 112 ? 36.557 43.736 25.124 1.00 0.60 ? 112 TYR A CE1 1 
ATOM 886  C CE2 . TYR A 1 112 ? 34.870 45.353 25.749 1.00 0.60 ? 112 TYR A CE2 1 
ATOM 887  C CZ  . TYR A 1 112 ? 36.083 44.707 26.010 1.00 0.60 ? 112 TYR A CZ  1 
ATOM 888  O OH  . TYR A 1 112 ? 36.789 44.994 27.192 1.00 0.60 ? 112 TYR A OH  1 
ATOM 889  N N   . LEU A 1 113 ? 30.743 41.817 22.703 1.00 0.55 ? 113 LEU A N   1 
ATOM 890  C CA  . LEU A 1 113 ? 29.489 41.379 22.105 1.00 0.55 ? 113 LEU A CA  1 
ATOM 891  C C   . LEU A 1 113 ? 28.874 42.230 20.997 1.00 0.55 ? 113 LEU A C   1 
ATOM 892  O O   . LEU A 1 113 ? 28.885 43.460 21.005 1.00 0.55 ? 113 LEU A O   1 
ATOM 893  C CB  . LEU A 1 113 ? 28.373 41.137 23.152 1.00 0.55 ? 113 LEU A CB  1 
ATOM 894  C CG  . LEU A 1 113 ? 28.700 40.145 24.283 1.00 0.55 ? 113 LEU A CG  1 
ATOM 895  C CD1 . LEU A 1 113 ? 27.467 39.958 25.181 1.00 0.55 ? 113 LEU A CD1 1 
ATOM 896  C CD2 . LEU A 1 113 ? 29.196 38.777 23.785 1.00 0.55 ? 113 LEU A CD2 1 
ATOM 897  N N   . GLY A 1 114 ? 28.216 41.547 20.034 1.00 0.51 ? 114 GLY A N   1 
ATOM 898  C CA  . GLY A 1 114 ? 27.502 42.203 18.952 1.00 0.51 ? 114 GLY A CA  1 
ATOM 899  C C   . GLY A 1 114 ? 28.275 42.519 17.708 1.00 0.51 ? 114 GLY A C   1 
ATOM 900  O O   . GLY A 1 114 ? 27.780 43.287 16.888 1.00 0.51 ? 114 GLY A O   1 
ATOM 901  N N   . THR A 1 115 ? 29.492 41.985 17.519 1.00 0.39 ? 115 THR A N   1 
ATOM 902  C CA  . THR A 1 115 ? 30.304 42.243 16.341 1.00 0.39 ? 115 THR A CA  1 
ATOM 903  C C   . THR A 1 115 ? 30.340 41.007 15.444 1.00 0.39 ? 115 THR A C   1 
ATOM 904  O O   . THR A 1 115 ? 30.470 39.872 15.887 1.00 0.39 ? 115 THR A O   1 
ATOM 905  C CB  . THR A 1 115 ? 31.713 42.741 16.690 1.00 0.39 ? 115 THR A CB  1 
ATOM 906  O OG1 . THR A 1 115 ? 32.428 41.842 17.512 1.00 0.39 ? 115 THR A OG1 1 
ATOM 907  C CG2 . THR A 1 115 ? 31.646 44.031 17.522 1.00 0.39 ? 115 THR A CG2 1 
ATOM 908  N N   . GLY A 1 116 ? 30.138 41.156 14.113 1.00 0.37 ? 116 GLY A N   1 
ATOM 909  C CA  . GLY A 1 116 ? 30.085 39.960 13.283 1.00 0.37 ? 116 GLY A CA  1 
ATOM 910  C C   . GLY A 1 116 ? 29.681 40.288 11.872 1.00 0.37 ? 116 GLY A C   1 
ATOM 911  O O   . GLY A 1 116 ? 29.902 41.418 11.437 1.00 0.37 ? 116 GLY A O   1 
ATOM 912  N N   . PRO A 1 117 ? 29.104 39.356 11.109 1.00 0.27 ? 117 PRO A N   1 
ATOM 913  C CA  . PRO A 1 117 ? 28.484 39.620 9.806  1.00 0.27 ? 117 PRO A CA  1 
ATOM 914  C C   . PRO A 1 117 ? 27.379 40.672 9.769  1.00 0.27 ? 117 PRO A C   1 
ATOM 915  O O   . PRO A 1 117 ? 26.893 41.089 10.817 1.00 0.27 ? 117 PRO A O   1 
ATOM 916  C CB  . PRO A 1 117 ? 27.920 38.250 9.375  1.00 0.27 ? 117 PRO A CB  1 
ATOM 917  C CG  . PRO A 1 117 ? 28.709 37.222 10.188 1.00 0.27 ? 117 PRO A CG  1 
ATOM 918  C CD  . PRO A 1 117 ? 28.972 37.952 11.502 1.00 0.27 ? 117 PRO A CD  1 
ATOM 919  N N   . GLU A 1 118 ? 26.907 41.026 8.543  1.00 0.21 ? 118 GLU A N   1 
ATOM 920  C CA  . GLU A 1 118 ? 25.890 42.030 8.213  1.00 0.21 ? 118 GLU A CA  1 
ATOM 921  C C   . GLU A 1 118 ? 24.570 41.891 8.981  1.00 0.21 ? 118 GLU A C   1 
ATOM 922  O O   . GLU A 1 118 ? 23.847 42.850 9.236  1.00 0.21 ? 118 GLU A O   1 
ATOM 923  C CB  . GLU A 1 118 ? 25.621 41.966 6.679  1.00 0.21 ? 118 GLU A CB  1 
ATOM 924  C CG  . GLU A 1 118 ? 24.718 43.093 6.093  1.00 0.21 ? 118 GLU A CG  1 
ATOM 925  C CD  . GLU A 1 118 ? 25.329 44.495 6.158  1.00 0.21 ? 118 GLU A CD  1 
ATOM 926  O OE1 . GLU A 1 118 ? 26.569 44.605 6.327  1.00 0.21 ? 118 GLU A OE1 1 
ATOM 927  O OE2 . GLU A 1 118 ? 24.545 45.481 6.042  1.00 0.21 ? 118 GLU A OE2 1 
ATOM 928  N N   . ALA A 1 119 ? 24.243 40.661 9.421  1.00 0.24 ? 119 ALA A N   1 
ATOM 929  C CA  . ALA A 1 119 ? 23.101 40.361 10.256 1.00 0.24 ? 119 ALA A CA  1 
ATOM 930  C C   . ALA A 1 119 ? 23.191 40.907 11.690 1.00 0.24 ? 119 ALA A C   1 
ATOM 931  O O   . ALA A 1 119 ? 22.189 40.930 12.402 1.00 0.24 ? 119 ALA A O   1 
ATOM 932  C CB  . ALA A 1 119 ? 22.922 38.827 10.304 1.00 0.24 ? 119 ALA A CB  1 
ATOM 933  N N   . GLY A 1 120 ? 24.382 41.352 12.164 1.00 0.33 ? 120 GLY A N   1 
ATOM 934  C CA  . GLY A 1 120 ? 24.520 42.002 13.470 1.00 0.33 ? 120 GLY A CA  1 
ATOM 935  C C   . GLY A 1 120 ? 24.443 41.076 14.656 1.00 0.33 ? 120 GLY A C   1 
ATOM 936  O O   . GLY A 1 120 ? 23.867 41.397 15.694 1.00 0.33 ? 120 GLY A O   1 
ATOM 937  N N   . LEU A 1 121 ? 25.019 39.872 14.502 1.00 0.29 ? 121 LEU A N   1 
ATOM 938  C CA  . LEU A 1 121 ? 24.938 38.780 15.449 1.00 0.29 ? 121 LEU A CA  1 
ATOM 939  C C   . LEU A 1 121 ? 25.526 39.072 16.838 1.00 0.29 ? 121 LEU A C   1 
ATOM 940  O O   . LEU A 1 121 ? 26.499 39.815 16.948 1.00 0.29 ? 121 LEU A O   1 
ATOM 941  C CB  . LEU A 1 121 ? 25.595 37.503 14.867 1.00 0.29 ? 121 LEU A CB  1 
ATOM 942  C CG  . LEU A 1 121 ? 25.012 37.006 13.525 1.00 0.29 ? 121 LEU A CG  1 
ATOM 943  C CD1 . LEU A 1 121 ? 25.789 35.767 13.047 1.00 0.29 ? 121 LEU A CD1 1 
ATOM 944  C CD2 . LEU A 1 121 ? 23.510 36.681 13.603 1.00 0.29 ? 121 LEU A CD2 1 
ATOM 945  N N   . PRO A 1 122 ? 25.004 38.533 17.948 1.00 0.51 ? 122 PRO A N   1 
ATOM 946  C CA  . PRO A 1 122 ? 25.558 38.772 19.276 1.00 0.51 ? 122 PRO A CA  1 
ATOM 947  C C   . PRO A 1 122 ? 26.948 38.169 19.435 1.00 0.51 ? 122 PRO A C   1 
ATOM 948  O O   . PRO A 1 122 ? 27.769 38.710 20.178 1.00 0.51 ? 122 PRO A O   1 
ATOM 949  C CB  . PRO A 1 122 ? 24.500 38.188 20.232 1.00 0.51 ? 122 PRO A CB  1 
ATOM 950  C CG  . PRO A 1 122 ? 23.791 37.114 19.405 1.00 0.51 ? 122 PRO A CG  1 
ATOM 951  C CD  . PRO A 1 122 ? 23.811 37.690 17.989 1.00 0.51 ? 122 PRO A CD  1 
ATOM 952  N N   . TYR A 1 123 ? 27.236 37.061 18.737 1.00 0.24 ? 123 TYR A N   1 
ATOM 953  C CA  . TYR A 1 123 ? 28.525 36.406 18.696 1.00 0.24 ? 123 TYR A CA  1 
ATOM 954  C C   . TYR A 1 123 ? 28.995 36.357 17.249 1.00 0.24 ? 123 TYR A C   1 
ATOM 955  O O   . TYR A 1 123 ? 28.186 36.227 16.333 1.00 0.24 ? 123 TYR A O   1 
ATOM 956  C CB  . TYR A 1 123 ? 28.506 35.010 19.387 1.00 0.24 ? 123 TYR A CB  1 
ATOM 957  C CG  . TYR A 1 123 ? 27.484 34.075 18.794 1.00 0.24 ? 123 TYR A CG  1 
ATOM 958  C CD1 . TYR A 1 123 ? 27.804 33.313 17.662 1.00 0.24 ? 123 TYR A CD1 1 
ATOM 959  C CD2 . TYR A 1 123 ? 26.203 33.947 19.354 1.00 0.24 ? 123 TYR A CD2 1 
ATOM 960  C CE1 . TYR A 1 123 ? 26.860 32.456 17.086 1.00 0.24 ? 123 TYR A CE1 1 
ATOM 961  C CE2 . TYR A 1 123 ? 25.256 33.085 18.781 1.00 0.24 ? 123 TYR A CE2 1 
ATOM 962  C CZ  . TYR A 1 123 ? 25.585 32.349 17.639 1.00 0.24 ? 123 TYR A CZ  1 
ATOM 963  O OH  . TYR A 1 123 ? 24.645 31.495 17.031 1.00 0.24 ? 123 TYR A OH  1 
ATOM 964  N N   . GLY A 1 124 ? 30.318 36.491 17.004 1.00 0.29 ? 124 GLY A N   1 
ATOM 965  C CA  . GLY A 1 124 ? 30.856 36.635 15.650 1.00 0.29 ? 124 GLY A CA  1 
ATOM 966  C C   . GLY A 1 124 ? 30.886 35.398 14.786 1.00 0.29 ? 124 GLY A C   1 
ATOM 967  O O   . GLY A 1 124 ? 30.729 35.463 13.568 1.00 0.29 ? 124 GLY A O   1 
ATOM 968  N N   . ALA A 1 125 ? 31.086 34.218 15.393 1.00 0.43 ? 125 ALA A N   1 
ATOM 969  C CA  . ALA A 1 125 ? 31.097 32.971 14.674 1.00 0.43 ? 125 ALA A CA  1 
ATOM 970  C C   . ALA A 1 125 ? 30.754 31.846 15.633 1.00 0.43 ? 125 ALA A C   1 
ATOM 971  O O   . ALA A 1 125 ? 30.941 31.977 16.839 1.00 0.43 ? 125 ALA A O   1 
ATOM 972  C CB  . ALA A 1 125 ? 32.478 32.717 14.023 1.00 0.43 ? 125 ALA A CB  1 
ATOM 973  N N   . ASN A 1 126 ? 30.218 30.719 15.106 1.00 0.36 ? 126 ASN A N   1 
ATOM 974  C CA  . ASN A 1 126 ? 29.768 29.568 15.885 1.00 0.36 ? 126 ASN A CA  1 
ATOM 975  C C   . ASN A 1 126 ? 30.889 28.667 16.414 1.00 0.36 ? 126 ASN A C   1 
ATOM 976  O O   . ASN A 1 126 ? 30.725 27.965 17.404 1.00 0.36 ? 126 ASN A O   1 
ATOM 977  C CB  . ASN A 1 126 ? 28.804 28.742 14.975 1.00 0.36 ? 126 ASN A CB  1 
ATOM 978  C CG  . ASN A 1 126 ? 28.106 27.594 15.709 1.00 0.36 ? 126 ASN A CG  1 
ATOM 979  O OD1 . ASN A 1 126 ? 27.415 27.805 16.702 1.00 0.36 ? 126 ASN A OD1 1 
ATOM 980  N ND2 . ASN A 1 126 ? 28.257 26.348 15.198 1.00 0.36 ? 126 ASN A ND2 1 
ATOM 981  N N   . LYS A 1 127 ? 32.050 28.615 15.731 1.00 0.42 ? 127 LYS A N   1 
ATOM 982  C CA  . LYS A 1 127 ? 33.120 27.703 16.102 1.00 0.42 ? 127 LYS A CA  1 
ATOM 983  C C   . LYS A 1 127 ? 33.838 28.043 17.404 1.00 0.42 ? 127 LYS A C   1 
ATOM 984  O O   . LYS A 1 127 ? 34.060 27.169 18.240 1.00 0.42 ? 127 LYS A O   1 
ATOM 985  C CB  . LYS A 1 127 ? 34.156 27.609 14.958 1.00 0.42 ? 127 LYS A CB  1 
ATOM 986  C CG  . LYS A 1 127 ? 33.602 26.943 13.686 1.00 0.42 ? 127 LYS A CG  1 
ATOM 987  C CD  . LYS A 1 127 ? 34.705 26.605 12.663 1.00 0.42 ? 127 LYS A CD  1 
ATOM 988  C CE  . LYS A 1 127 ? 35.398 27.799 11.995 1.00 0.42 ? 127 LYS A CE  1 
ATOM 989  N NZ  . LYS A 1 127 ? 34.518 28.388 10.962 1.00 0.42 ? 127 LYS A NZ  1 
ATOM 990  N N   . ASP A 1 128 ? 34.207 29.323 17.601 1.00 0.39 ? 128 ASP A N   1 
ATOM 991  C CA  . ASP A 1 128 ? 34.801 29.797 18.832 1.00 0.39 ? 128 ASP A CA  1 
ATOM 992  C C   . ASP A 1 128 ? 33.751 30.007 19.917 1.00 0.39 ? 128 ASP A C   1 
ATOM 993  O O   . ASP A 1 128 ? 32.729 30.663 19.723 1.00 0.39 ? 128 ASP A O   1 
ATOM 994  C CB  . ASP A 1 128 ? 35.542 31.137 18.630 1.00 0.39 ? 128 ASP A CB  1 
ATOM 995  C CG  . ASP A 1 128 ? 36.752 31.009 17.726 1.00 0.39 ? 128 ASP A CG  1 
ATOM 996  O OD1 . ASP A 1 128 ? 37.377 29.921 17.703 1.00 0.39 ? 128 ASP A OD1 1 
ATOM 997  O OD2 . ASP A 1 128 ? 37.096 32.035 17.089 1.00 0.39 ? 128 ASP A OD2 1 
ATOM 998  N N   . GLY A 1 129 ? 33.993 29.455 21.120 1.00 0.55 ? 129 GLY A N   1 
ATOM 999  C CA  . GLY A 1 129 ? 32.999 29.424 22.185 1.00 0.55 ? 129 GLY A CA  1 
ATOM 1000 C C   . GLY A 1 129 ? 33.016 30.620 23.095 1.00 0.55 ? 129 GLY A C   1 
ATOM 1001 O O   . GLY A 1 129 ? 33.919 30.767 23.918 1.00 0.55 ? 129 GLY A O   1 
ATOM 1002 N N   . ILE A 1 130 ? 31.997 31.500 23.002 1.00 0.49 ? 130 ILE A N   1 
ATOM 1003 C CA  . ILE A 1 130 ? 31.748 32.558 23.979 1.00 0.49 ? 130 ILE A CA  1 
ATOM 1004 C C   . ILE A 1 130 ? 31.224 31.959 25.280 1.00 0.49 ? 130 ILE A C   1 
ATOM 1005 O O   . ILE A 1 130 ? 30.399 31.050 25.267 1.00 0.49 ? 130 ILE A O   1 
ATOM 1006 C CB  . ILE A 1 130 ? 30.826 33.659 23.437 1.00 0.49 ? 130 ILE A CB  1 
ATOM 1007 C CG1 . ILE A 1 130 ? 31.337 34.211 22.080 1.00 0.49 ? 130 ILE A CG1 1 
ATOM 1008 C CG2 . ILE A 1 130 ? 30.641 34.805 24.460 1.00 0.49 ? 130 ILE A CG2 1 
ATOM 1009 C CD1 . ILE A 1 130 ? 32.787 34.713 22.097 1.00 0.49 ? 130 ILE A CD1 1 
ATOM 1010 N N   . ILE A 1 131 ? 31.740 32.417 26.443 1.00 0.50 ? 131 ILE A N   1 
ATOM 1011 C CA  . ILE A 1 131 ? 31.493 31.740 27.717 1.00 0.50 ? 131 ILE A CA  1 
ATOM 1012 C C   . ILE A 1 131 ? 30.480 32.484 28.589 1.00 0.50 ? 131 ILE A C   1 
ATOM 1013 O O   . ILE A 1 131 ? 29.917 31.931 29.529 1.00 0.50 ? 131 ILE A O   1 
ATOM 1014 C CB  . ILE A 1 131 ? 32.854 31.513 28.384 1.00 0.50 ? 131 ILE A CB  1 
ATOM 1015 C CG1 . ILE A 1 131 ? 33.666 30.544 27.484 1.00 0.50 ? 131 ILE A CG1 1 
ATOM 1016 C CG2 . ILE A 1 131 ? 32.734 30.944 29.817 1.00 0.50 ? 131 ILE A CG2 1 
ATOM 1017 C CD1 . ILE A 1 131 ? 35.146 30.421 27.838 1.00 0.50 ? 131 ILE A CD1 1 
ATOM 1018 N N   . TRP A 1 132 ? 30.173 33.755 28.257 1.00 0.37 ? 132 TRP A N   1 
ATOM 1019 C CA  . TRP A 1 132 ? 29.054 34.533 28.795 1.00 0.37 ? 132 TRP A CA  1 
ATOM 1020 C C   . TRP A 1 132 ? 29.078 34.851 30.302 1.00 0.37 ? 132 TRP A C   1 
ATOM 1021 O O   . TRP A 1 132 ? 28.126 35.398 30.852 1.00 0.37 ? 132 TRP A O   1 
ATOM 1022 C CB  . TRP A 1 132 ? 27.670 33.950 28.383 1.00 0.37 ? 132 TRP A CB  1 
ATOM 1023 C CG  . TRP A 1 132 ? 27.521 33.527 26.923 1.00 0.37 ? 132 TRP A CG  1 
ATOM 1024 C CD1 . TRP A 1 132 ? 27.607 32.256 26.432 1.00 0.37 ? 132 TRP A CD1 1 
ATOM 1025 C CD2 . TRP A 1 132 ? 27.245 34.375 25.787 1.00 0.37 ? 132 TRP A CD2 1 
ATOM 1026 N NE1 . TRP A 1 132 ? 27.426 32.254 25.068 1.00 0.37 ? 132 TRP A NE1 1 
ATOM 1027 C CE2 . TRP A 1 132 ? 27.201 33.537 24.651 1.00 0.37 ? 132 TRP A CE2 1 
ATOM 1028 C CE3 . TRP A 1 132 ? 27.041 35.746 25.665 1.00 0.37 ? 132 TRP A CE3 1 
ATOM 1029 C CZ2 . TRP A 1 132 ? 26.965 34.055 23.387 1.00 0.37 ? 132 TRP A CZ2 1 
ATOM 1030 C CZ3 . TRP A 1 132 ? 26.789 36.264 24.386 1.00 0.37 ? 132 TRP A CZ3 1 
ATOM 1031 C CH2 . TRP A 1 132 ? 26.758 35.435 23.257 1.00 0.37 ? 132 TRP A CH2 1 
ATOM 1032 N N   . VAL A 1 133 ? 30.188 34.576 31.019 1.00 0.39 ? 133 VAL A N   1 
ATOM 1033 C CA  . VAL A 1 133 ? 30.351 34.920 32.426 1.00 0.39 ? 133 VAL A CA  1 
ATOM 1034 C C   . VAL A 1 133 ? 30.684 36.397 32.649 1.00 0.39 ? 133 VAL A C   1 
ATOM 1035 O O   . VAL A 1 133 ? 31.650 36.929 32.104 1.00 0.39 ? 133 VAL A O   1 
ATOM 1036 C CB  . VAL A 1 133 ? 31.368 34.022 33.151 1.00 0.39 ? 133 VAL A CB  1 
ATOM 1037 C CG1 . VAL A 1 133 ? 30.806 32.588 33.239 1.00 0.39 ? 133 VAL A CG1 1 
ATOM 1038 C CG2 . VAL A 1 133 ? 32.750 34.017 32.460 1.00 0.39 ? 133 VAL A CG2 1 
ATOM 1039 N N   . ALA A 1 134 ? 29.872 37.104 33.466 1.00 0.54 ? 134 ALA A N   1 
ATOM 1040 C CA  . ALA A 1 134 ? 30.139 38.471 33.853 1.00 0.54 ? 134 ALA A CA  1 
ATOM 1041 C C   . ALA A 1 134 ? 29.345 38.823 35.104 1.00 0.54 ? 134 ALA A C   1 
ATOM 1042 O O   . ALA A 1 134 ? 28.466 38.080 35.542 1.00 0.54 ? 134 ALA A O   1 
ATOM 1043 C CB  . ALA A 1 134 ? 29.815 39.475 32.722 1.00 0.54 ? 134 ALA A CB  1 
ATOM 1044 N N   . THR A 1 135 ? 29.688 39.957 35.749 1.00 0.52 ? 135 THR A N   1 
ATOM 1045 C CA  . THR A 1 135 ? 28.967 40.548 36.872 1.00 0.52 ? 135 THR A CA  1 
ATOM 1046 C C   . THR A 1 135 ? 27.621 41.147 36.462 1.00 0.52 ? 135 THR A C   1 
ATOM 1047 O O   . THR A 1 135 ? 27.521 41.876 35.483 1.00 0.52 ? 135 THR A O   1 
ATOM 1048 C CB  . THR A 1 135 ? 29.791 41.632 37.578 1.00 0.52 ? 135 THR A CB  1 
ATOM 1049 O OG1 . THR A 1 135 ? 30.315 42.583 36.661 1.00 0.52 ? 135 THR A OG1 1 
ATOM 1050 C CG2 . THR A 1 135 ? 31.020 41.006 38.253 1.00 0.52 ? 135 THR A CG2 1 
ATOM 1051 N N   . GLU A 1 136 ? 26.548 40.904 37.253 1.00 0.48 ? 136 GLU A N   1 
ATOM 1052 C CA  . GLU A 1 136 ? 25.185 41.402 37.019 1.00 0.48 ? 136 GLU A CA  1 
ATOM 1053 C C   . GLU A 1 136 ? 25.062 42.927 37.044 1.00 0.48 ? 136 GLU A C   1 
ATOM 1054 O O   . GLU A 1 136 ? 24.199 43.541 36.421 1.00 0.48 ? 136 GLU A O   1 
ATOM 1055 C CB  . GLU A 1 136 ? 24.247 40.787 38.096 1.00 0.48 ? 136 GLU A CB  1 
ATOM 1056 C CG  . GLU A 1 136 ? 22.741 41.167 38.037 1.00 0.48 ? 136 GLU A CG  1 
ATOM 1057 C CD  . GLU A 1 136 ? 21.983 40.510 36.883 1.00 0.48 ? 136 GLU A CD  1 
ATOM 1058 O OE1 . GLU A 1 136 ? 22.628 39.772 36.093 1.00 0.48 ? 136 GLU A OE1 1 
ATOM 1059 O OE2 . GLU A 1 136 ? 20.737 40.672 36.859 1.00 0.48 ? 136 GLU A OE2 1 
ATOM 1060 N N   . GLY A 1 137 ? 25.984 43.592 37.767 1.00 0.51 ? 137 GLY A N   1 
ATOM 1061 C CA  . GLY A 1 137 ? 26.051 45.044 37.865 1.00 0.51 ? 137 GLY A CA  1 
ATOM 1062 C C   . GLY A 1 137 ? 26.640 45.760 36.675 1.00 0.51 ? 137 GLY A C   1 
ATOM 1063 O O   . GLY A 1 137 ? 26.761 46.980 36.716 1.00 0.51 ? 137 GLY A O   1 
ATOM 1064 N N   . ALA A 1 138 ? 27.054 45.048 35.603 1.00 0.54 ? 138 ALA A N   1 
ATOM 1065 C CA  . ALA A 1 138 ? 27.480 45.658 34.355 1.00 0.54 ? 138 ALA A CA  1 
ATOM 1066 C C   . ALA A 1 138 ? 26.386 46.514 33.715 1.00 0.54 ? 138 ALA A C   1 
ATOM 1067 O O   . ALA A 1 138 ? 25.217 46.146 33.689 1.00 0.54 ? 138 ALA A O   1 
ATOM 1068 C CB  . ALA A 1 138 ? 27.950 44.566 33.371 1.00 0.54 ? 138 ALA A CB  1 
ATOM 1069 N N   . LEU A 1 139 ? 26.735 47.704 33.198 1.00 0.42 ? 139 LEU A N   1 
ATOM 1070 C CA  . LEU A 1 139 ? 25.771 48.727 32.844 1.00 0.42 ? 139 LEU A CA  1 
ATOM 1071 C C   . LEU A 1 139 ? 25.482 48.717 31.352 1.00 0.42 ? 139 LEU A C   1 
ATOM 1072 O O   . LEU A 1 139 ? 24.492 49.280 30.884 1.00 0.42 ? 139 LEU A O   1 
ATOM 1073 C CB  . LEU A 1 139 ? 26.351 50.091 33.297 1.00 0.42 ? 139 LEU A CB  1 
ATOM 1074 C CG  . LEU A 1 139 ? 25.396 51.303 33.274 1.00 0.42 ? 139 LEU A CG  1 
ATOM 1075 C CD1 . LEU A 1 139 ? 24.180 51.108 34.196 1.00 0.42 ? 139 LEU A CD1 1 
ATOM 1076 C CD2 . LEU A 1 139 ? 26.148 52.583 33.678 1.00 0.42 ? 139 LEU A CD2 1 
ATOM 1077 N N   . ASN A 1 140 ? 26.327 48.012 30.575 1.00 0.49 ? 140 ASN A N   1 
ATOM 1078 C CA  . ASN A 1 140 ? 26.157 47.718 29.164 1.00 0.49 ? 140 ASN A CA  1 
ATOM 1079 C C   . ASN A 1 140 ? 26.143 48.964 28.266 1.00 0.49 ? 140 ASN A C   1 
ATOM 1080 O O   . ASN A 1 140 ? 25.372 49.043 27.306 1.00 0.49 ? 140 ASN A O   1 
ATOM 1081 C CB  . ASN A 1 140 ? 24.912 46.817 28.909 1.00 0.49 ? 140 ASN A CB  1 
ATOM 1082 C CG  . ASN A 1 140 ? 25.022 45.514 29.690 1.00 0.49 ? 140 ASN A CG  1 
ATOM 1083 O OD1 . ASN A 1 140 ? 25.871 44.687 29.349 1.00 0.49 ? 140 ASN A OD1 1 
ATOM 1084 N ND2 . ASN A 1 140 ? 24.147 45.284 30.695 1.00 0.49 ? 140 ASN A ND2 1 
ATOM 1085 N N   . THR A 1 141 ? 26.993 49.974 28.568 1.00 0.40 ? 141 THR A N   1 
ATOM 1086 C CA  . THR A 1 141 ? 27.058 51.266 27.876 1.00 0.40 ? 141 THR A CA  1 
ATOM 1087 C C   . THR A 1 141 ? 27.632 51.202 26.462 1.00 0.40 ? 141 THR A C   1 
ATOM 1088 O O   . THR A 1 141 ? 28.539 50.410 26.192 1.00 0.40 ? 141 THR A O   1 
ATOM 1089 C CB  . THR A 1 141 ? 27.740 52.409 28.646 1.00 0.40 ? 141 THR A CB  1 
ATOM 1090 O OG1 . THR A 1 141 ? 29.132 52.231 28.856 1.00 0.40 ? 141 THR A OG1 1 
ATOM 1091 C CG2 . THR A 1 141 ? 27.067 52.563 30.020 1.00 0.40 ? 141 THR A CG2 1 
ATOM 1092 N N   . PRO A 1 142 ? 27.173 51.990 25.492 1.00 0.37 ? 142 PRO A N   1 
ATOM 1093 C CA  . PRO A 1 142 ? 27.802 52.020 24.178 1.00 0.37 ? 142 PRO A CA  1 
ATOM 1094 C C   . PRO A 1 142 ? 29.036 52.913 24.157 1.00 0.37 ? 142 PRO A C   1 
ATOM 1095 O O   . PRO A 1 142 ? 29.008 54.028 24.679 1.00 0.37 ? 142 PRO A O   1 
ATOM 1096 C CB  . PRO A 1 142 ? 26.695 52.564 23.261 1.00 0.37 ? 142 PRO A CB  1 
ATOM 1097 C CG  . PRO A 1 142 ? 25.826 53.436 24.174 1.00 0.37 ? 142 PRO A CG  1 
ATOM 1098 C CD  . PRO A 1 142 ? 25.911 52.731 25.526 1.00 0.37 ? 142 PRO A CD  1 
ATOM 1099 N N   . LYS A 1 143 ? 30.134 52.462 23.513 1.00 0.38 ? 143 LYS A N   1 
ATOM 1100 C CA  . LYS A 1 143 ? 31.305 53.290 23.321 1.00 0.38 ? 143 LYS A CA  1 
ATOM 1101 C C   . LYS A 1 143 ? 32.068 52.798 22.097 1.00 0.38 ? 143 LYS A C   1 
ATOM 1102 O O   . LYS A 1 143 ? 32.001 51.618 21.755 1.00 0.38 ? 143 LYS A O   1 
ATOM 1103 C CB  . LYS A 1 143 ? 32.213 53.284 24.582 1.00 0.38 ? 143 LYS A CB  1 
ATOM 1104 C CG  . LYS A 1 143 ? 33.282 54.389 24.583 1.00 0.38 ? 143 LYS A CG  1 
ATOM 1105 C CD  . LYS A 1 143 ? 33.953 54.610 25.949 1.00 0.38 ? 143 LYS A CD  1 
ATOM 1106 C CE  . LYS A 1 143 ? 34.959 55.769 25.902 1.00 0.38 ? 143 LYS A CE  1 
ATOM 1107 N NZ  . LYS A 1 143 ? 35.562 56.041 27.224 1.00 0.38 ? 143 LYS A NZ  1 
ATOM 1108 N N   . ASP A 1 144 ? 32.796 53.691 21.379 1.00 0.37 ? 144 ASP A N   1 
ATOM 1109 C CA  . ASP A 1 144 ? 33.591 53.359 20.205 1.00 0.37 ? 144 ASP A CA  1 
ATOM 1110 C C   . ASP A 1 144 ? 34.900 52.653 20.575 1.00 0.37 ? 144 ASP A C   1 
ATOM 1111 O O   . ASP A 1 144 ? 35.331 51.680 19.958 1.00 0.37 ? 144 ASP A O   1 
ATOM 1112 C CB  . ASP A 1 144 ? 33.895 54.649 19.381 1.00 0.37 ? 144 ASP A CB  1 
ATOM 1113 C CG  . ASP A 1 144 ? 32.662 55.350 18.848 1.00 0.37 ? 144 ASP A CG  1 
ATOM 1114 O OD1 . ASP A 1 144 ? 31.538 54.792 18.836 1.00 0.37 ? 144 ASP A OD1 1 
ATOM 1115 O OD2 . ASP A 1 144 ? 32.774 56.524 18.410 1.00 0.37 ? 144 ASP A OD2 1 
ATOM 1116 N N   . HIS A 1 145 ? 35.553 53.134 21.653 1.00 0.49 ? 145 HIS A N   1 
ATOM 1117 C CA  . HIS A 1 145 ? 36.934 52.867 22.013 1.00 0.49 ? 145 HIS A CA  1 
ATOM 1118 C C   . HIS A 1 145 ? 37.276 51.457 22.473 1.00 0.49 ? 145 HIS A C   1 
ATOM 1119 O O   . HIS A 1 145 ? 38.447 51.093 22.525 1.00 0.49 ? 145 HIS A O   1 
ATOM 1120 C CB  . HIS A 1 145 ? 37.347 53.786 23.198 1.00 0.49 ? 145 HIS A CB  1 
ATOM 1121 C CG  . HIS A 1 145 ? 37.224 55.263 22.967 1.00 0.49 ? 145 HIS A CG  1 
ATOM 1122 N ND1 . HIS A 1 145 ? 35.993 55.842 22.700 1.00 0.49 ? 145 HIS A ND1 1 
ATOM 1123 C CD2 . HIS A 1 145 ? 38.185 56.218 23.032 1.00 0.49 ? 145 HIS A CD2 1 
ATOM 1124 C CE1 . HIS A 1 145 ? 36.243 57.133 22.590 1.00 0.49 ? 145 HIS A CE1 1 
ATOM 1125 N NE2 . HIS A 1 145 ? 37.553 57.415 22.785 1.00 0.49 ? 145 HIS A NE2 1 
ATOM 1126 N N   . ILE A 1 146 ? 36.277 50.651 22.869 1.00 0.59 ? 146 ILE A N   1 
ATOM 1127 C CA  . ILE A 1 146 ? 36.495 49.403 23.580 1.00 0.59 ? 146 ILE A CA  1 
ATOM 1128 C C   . ILE A 1 146 ? 36.463 48.188 22.690 1.00 0.59 ? 146 ILE A C   1 
ATOM 1129 O O   . ILE A 1 146 ? 36.901 47.110 23.084 1.00 0.59 ? 146 ILE A O   1 
ATOM 1130 C CB  . ILE A 1 146 ? 35.423 49.201 24.652 1.00 0.59 ? 146 ILE A CB  1 
ATOM 1131 C CG1 . ILE A 1 146 ? 33.984 49.085 24.075 1.00 0.59 ? 146 ILE A CG1 1 
ATOM 1132 C CG2 . ILE A 1 146 ? 35.568 50.347 25.678 1.00 0.59 ? 146 ILE A CG2 1 
ATOM 1133 C CD1 . ILE A 1 146 ? 32.898 48.854 25.135 1.00 0.59 ? 146 ILE A CD1 1 
ATOM 1134 N N   . GLY A 1 147 ? 35.944 48.316 21.449 1.00 0.58 ? 147 GLY A N   1 
ATOM 1135 C CA  . GLY A 1 147 ? 35.772 47.139 20.613 1.00 0.58 ? 147 GLY A CA  1 
ATOM 1136 C C   . GLY A 1 147 ? 37.053 46.666 20.046 1.00 0.58 ? 147 GLY A C   1 
ATOM 1137 O O   . GLY A 1 147 ? 37.391 45.495 20.198 1.00 0.58 ? 147 GLY A O   1 
ATOM 1138 N N   . THR A 1 148 ? 37.801 47.562 19.374 1.00 0.52 ? 148 THR A N   1 
ATOM 1139 C CA  . THR A 1 148 ? 39.006 47.190 18.665 1.00 0.52 ? 148 THR A CA  1 
ATOM 1140 C C   . THR A 1 148 ? 39.991 48.384 18.525 1.00 0.52 ? 148 THR A C   1 
ATOM 1141 O O   . THR A 1 148 ? 39.703 49.475 19.021 1.00 0.52 ? 148 THR A O   1 
ATOM 1142 C CB  . THR A 1 148 ? 38.759 46.478 17.332 1.00 0.52 ? 148 THR A CB  1 
ATOM 1143 O OG1 . THR A 1 148 ? 38.369 47.393 16.383 1.00 0.52 ? 148 THR A OG1 1 
ATOM 1144 C CG2 . THR A 1 148 ? 37.711 45.334 17.296 1.00 0.52 ? 148 THR A CG2 1 
ATOM 1145 N N   . ARG A 1 149 ? 41.210 48.246 17.914 1.00 0.44 ? 149 ARG A N   1 
ATOM 1146 C CA  . ARG A 1 149 ? 42.258 49.275 17.745 1.00 0.44 ? 149 ARG A CA  1 
ATOM 1147 C C   . ARG A 1 149 ? 41.920 50.362 16.741 1.00 0.44 ? 149 ARG A C   1 
ATOM 1148 O O   . ARG A 1 149 ? 41.817 50.147 15.536 1.00 0.44 ? 149 ARG A O   1 
ATOM 1149 C CB  . ARG A 1 149 ? 43.605 48.647 17.264 1.00 0.44 ? 149 ARG A CB  1 
ATOM 1150 C CG  . ARG A 1 149 ? 44.894 49.497 17.143 1.00 0.44 ? 149 ARG A CG  1 
ATOM 1151 C CD  . ARG A 1 149 ? 46.081 48.651 16.632 1.00 0.44 ? 149 ARG A CD  1 
ATOM 1152 N NE  . ARG A 1 149 ? 46.501 47.716 17.727 1.00 0.44 ? 149 ARG A NE  1 
ATOM 1153 C CZ  . ARG A 1 149 ? 47.184 46.572 17.573 1.00 0.44 ? 149 ARG A CZ  1 
ATOM 1154 N NH1 . ARG A 1 149 ? 47.642 45.987 18.677 1.00 0.44 ? 149 ARG A NH1 1 
ATOM 1155 N NH2 . ARG A 1 149 ? 47.412 46.011 16.396 1.00 0.44 ? 149 ARG A NH2 1 
ATOM 1156 N N   . ASN A 1 150 ? 41.846 51.605 17.232 1.00 0.45 ? 150 ASN A N   1 
ATOM 1157 C CA  . ASN A 1 150 ? 41.664 52.782 16.426 1.00 0.45 ? 150 ASN A CA  1 
ATOM 1158 C C   . ASN A 1 150 ? 42.426 53.885 17.129 1.00 0.45 ? 150 ASN A C   1 
ATOM 1159 O O   . ASN A 1 150 ? 42.664 53.747 18.328 1.00 0.45 ? 150 ASN A O   1 
ATOM 1160 C CB  . ASN A 1 150 ? 40.174 53.178 16.374 1.00 0.45 ? 150 ASN A CB  1 
ATOM 1161 C CG  . ASN A 1 150 ? 39.471 52.392 15.286 1.00 0.45 ? 150 ASN A CG  1 
ATOM 1162 O OD1 . ASN A 1 150 ? 38.725 51.464 15.575 1.00 0.45 ? 150 ASN A OD1 1 
ATOM 1163 N ND2 . ASN A 1 150 ? 39.665 52.772 14.003 1.00 0.45 ? 150 ASN A ND2 1 
ATOM 1164 N N   . PRO A 1 151 ? 42.793 54.994 16.483 1.00 0.33 ? 151 PRO A N   1 
ATOM 1165 C CA  . PRO A 1 151 ? 43.634 56.030 17.089 1.00 0.33 ? 151 PRO A CA  1 
ATOM 1166 C C   . PRO A 1 151 ? 43.019 56.790 18.251 1.00 0.33 ? 151 PRO A C   1 
ATOM 1167 O O   . PRO A 1 151 ? 43.712 57.574 18.888 1.00 0.33 ? 151 PRO A O   1 
ATOM 1168 C CB  . PRO A 1 151 ? 43.885 57.011 15.932 1.00 0.33 ? 151 PRO A CB  1 
ATOM 1169 C CG  . PRO A 1 151 ? 43.804 56.148 14.675 1.00 0.33 ? 151 PRO A CG  1 
ATOM 1170 C CD  . PRO A 1 151 ? 42.711 55.147 15.026 1.00 0.33 ? 151 PRO A CD  1 
ATOM 1171 N N   . ALA A 1 152 ? 41.724 56.580 18.543 1.00 0.39 ? 152 ALA A N   1 
ATOM 1172 C CA  . ALA A 1 152 ? 41.022 57.152 19.666 1.00 0.39 ? 152 ALA A CA  1 
ATOM 1173 C C   . ALA A 1 152 ? 41.408 56.524 21.006 1.00 0.39 ? 152 ALA A C   1 
ATOM 1174 O O   . ALA A 1 152 ? 41.068 57.059 22.058 1.00 0.39 ? 152 ALA A O   1 
ATOM 1175 C CB  . ALA A 1 152 ? 39.508 56.953 19.439 1.00 0.39 ? 152 ALA A CB  1 
ATOM 1176 N N   . ASN A 1 153 ? 42.104 55.367 21.006 1.00 0.47 ? 153 ASN A N   1 
ATOM 1177 C CA  . ASN A 1 153 ? 42.468 54.659 22.215 1.00 0.47 ? 153 ASN A CA  1 
ATOM 1178 C C   . ASN A 1 153 ? 43.896 54.131 22.087 1.00 0.47 ? 153 ASN A C   1 
ATOM 1179 O O   . ASN A 1 153 ? 44.468 54.065 20.999 1.00 0.47 ? 153 ASN A O   1 
ATOM 1180 C CB  . ASN A 1 153 ? 41.458 53.499 22.439 1.00 0.47 ? 153 ASN A CB  1 
ATOM 1181 C CG  . ASN A 1 153 ? 41.477 52.944 23.861 1.00 0.47 ? 153 ASN A CG  1 
ATOM 1182 O OD1 . ASN A 1 153 ? 42.161 53.442 24.757 1.00 0.47 ? 153 ASN A OD1 1 
ATOM 1183 N ND2 . ASN A 1 153 ? 40.676 51.881 24.093 1.00 0.47 ? 153 ASN A ND2 1 
ATOM 1184 N N   . ASN A 1 154 ? 44.505 53.728 23.223 1.00 0.45 ? 154 ASN A N   1 
ATOM 1185 C CA  . ASN A 1 154 ? 45.787 53.043 23.282 1.00 0.45 ? 154 ASN A CA  1 
ATOM 1186 C C   . ASN A 1 154 ? 45.746 51.713 22.535 1.00 0.45 ? 154 ASN A C   1 
ATOM 1187 O O   . ASN A 1 154 ? 44.730 51.027 22.487 1.00 0.45 ? 154 ASN A O   1 
ATOM 1188 C CB  . ASN A 1 154 ? 46.258 52.806 24.739 1.00 0.45 ? 154 ASN A CB  1 
ATOM 1189 C CG  . ASN A 1 154 ? 46.530 54.150 25.402 1.00 0.45 ? 154 ASN A CG  1 
ATOM 1190 O OD1 . ASN A 1 154 ? 47.139 55.040 24.812 1.00 0.45 ? 154 ASN A OD1 1 
ATOM 1191 N ND2 . ASN A 1 154 ? 46.103 54.306 26.675 1.00 0.45 ? 154 ASN A ND2 1 
ATOM 1192 N N   . ALA A 1 155 ? 46.870 51.304 21.914 1.00 0.45 ? 155 ALA A N   1 
ATOM 1193 C CA  . ALA A 1 155 ? 46.862 50.258 20.907 1.00 0.45 ? 155 ALA A CA  1 
ATOM 1194 C C   . ALA A 1 155 ? 46.693 48.813 21.401 1.00 0.45 ? 155 ALA A C   1 
ATOM 1195 O O   . ALA A 1 155 ? 46.657 47.876 20.593 1.00 0.45 ? 155 ALA A O   1 
ATOM 1196 C CB  . ALA A 1 155 ? 48.153 50.379 20.070 1.00 0.45 ? 155 ALA A CB  1 
ATOM 1197 N N   . ALA A 1 156 ? 46.592 48.589 22.724 1.00 0.53 ? 156 ALA A N   1 
ATOM 1198 C CA  . ALA A 1 156 ? 46.384 47.281 23.295 1.00 0.53 ? 156 ALA A CA  1 
ATOM 1199 C C   . ALA A 1 156 ? 45.695 47.393 24.648 1.00 0.53 ? 156 ALA A C   1 
ATOM 1200 O O   . ALA A 1 156 ? 45.896 48.369 25.368 1.00 0.53 ? 156 ALA A O   1 
ATOM 1201 C CB  . ALA A 1 156 ? 47.733 46.551 23.477 1.00 0.53 ? 156 ALA A CB  1 
ATOM 1202 N N   . ILE A 1 157 ? 44.891 46.372 25.017 1.00 0.57 ? 157 ILE A N   1 
ATOM 1203 C CA  . ILE A 1 157 ? 44.123 46.319 26.252 1.00 0.57 ? 157 ILE A CA  1 
ATOM 1204 C C   . ILE A 1 157 ? 44.601 45.149 27.097 1.00 0.57 ? 157 ILE A C   1 
ATOM 1205 O O   . ILE A 1 157 ? 44.598 44.001 26.649 1.00 0.57 ? 157 ILE A O   1 
ATOM 1206 C CB  . ILE A 1 157 ? 42.639 46.074 25.991 1.00 0.57 ? 157 ILE A CB  1 
ATOM 1207 C CG1 . ILE A 1 157 ? 42.011 47.089 25.006 1.00 0.57 ? 157 ILE A CG1 1 
ATOM 1208 C CG2 . ILE A 1 157 ? 41.838 46.008 27.315 1.00 0.57 ? 157 ILE A CG2 1 
ATOM 1209 C CD1 . ILE A 1 157 ? 42.055 48.552 25.451 1.00 0.57 ? 157 ILE A CD1 1 
ATOM 1210 N N   . VAL A 1 158 ? 45.001 45.412 28.358 1.00 0.60 ? 158 VAL A N   1 
ATOM 1211 C CA  . VAL A 1 158 ? 45.424 44.393 29.314 1.00 0.60 ? 158 VAL A CA  1 
ATOM 1212 C C   . VAL A 1 158 ? 44.254 44.018 30.203 1.00 0.60 ? 158 VAL A C   1 
ATOM 1213 O O   . VAL A 1 158 ? 43.586 44.880 30.771 1.00 0.60 ? 158 VAL A O   1 
ATOM 1214 C CB  . VAL A 1 158 ? 46.603 44.847 30.188 1.00 0.60 ? 158 VAL A CB  1 
ATOM 1215 C CG1 . VAL A 1 158 ? 46.825 43.970 31.446 1.00 0.60 ? 158 VAL A CG1 1 
ATOM 1216 C CG2 . VAL A 1 158 ? 47.879 44.813 29.332 1.00 0.60 ? 158 VAL A CG2 1 
ATOM 1217 N N   . LEU A 1 159 ? 44.007 42.703 30.348 1.00 0.61 ? 159 LEU A N   1 
ATOM 1218 C CA  . LEU A 1 159 ? 43.045 42.122 31.254 1.00 0.61 ? 159 LEU A CA  1 
ATOM 1219 C C   . LEU A 1 159 ? 43.791 41.156 32.175 1.00 0.61 ? 159 LEU A C   1 
ATOM 1220 O O   . LEU A 1 159 ? 44.724 40.472 31.749 1.00 0.61 ? 159 LEU A O   1 
ATOM 1221 C CB  . LEU A 1 159 ? 41.903 41.406 30.485 1.00 0.61 ? 159 LEU A CB  1 
ATOM 1222 C CG  . LEU A 1 159 ? 41.151 42.326 29.491 1.00 0.61 ? 159 LEU A CG  1 
ATOM 1223 C CD1 . LEU A 1 159 ? 41.711 42.235 28.059 1.00 0.61 ? 159 LEU A CD1 1 
ATOM 1224 C CD2 . LEU A 1 159 ? 39.643 42.027 29.472 1.00 0.61 ? 159 LEU A CD2 1 
ATOM 1225 N N   . GLN A 1 160 ? 43.459 41.122 33.486 1.00 0.63 ? 160 GLN A N   1 
ATOM 1226 C CA  . GLN A 1 160 ? 44.196 40.331 34.452 1.00 0.63 ? 160 GLN A CA  1 
ATOM 1227 C C   . GLN A 1 160 ? 43.391 40.108 35.720 1.00 0.63 ? 160 GLN A C   1 
ATOM 1228 O O   . GLN A 1 160 ? 42.357 40.738 35.930 1.00 0.63 ? 160 GLN A O   1 
ATOM 1229 C CB  . GLN A 1 160 ? 45.542 41.023 34.817 1.00 0.63 ? 160 GLN A CB  1 
ATOM 1230 C CG  . GLN A 1 160 ? 45.372 42.439 35.419 1.00 0.63 ? 160 GLN A CG  1 
ATOM 1231 C CD  . GLN A 1 160 ? 46.697 43.195 35.497 1.00 0.63 ? 160 GLN A CD  1 
ATOM 1232 O OE1 . GLN A 1 160 ? 47.785 42.627 35.624 1.00 0.63 ? 160 GLN A OE1 1 
ATOM 1233 N NE2 . GLN A 1 160 ? 46.594 44.541 35.420 1.00 0.63 ? 160 GLN A NE2 1 
ATOM 1234 N N   . LEU A 1 161 ? 43.867 39.196 36.604 1.00 0.60 ? 161 LEU A N   1 
ATOM 1235 C CA  . LEU A 1 161 ? 43.238 38.845 37.869 1.00 0.60 ? 161 LEU A CA  1 
ATOM 1236 C C   . LEU A 1 161 ? 43.002 40.035 38.819 1.00 0.60 ? 161 LEU A C   1 
ATOM 1237 O O   . LEU A 1 161 ? 43.941 40.804 39.052 1.00 0.60 ? 161 LEU A O   1 
ATOM 1238 C CB  . LEU A 1 161 ? 44.117 37.826 38.653 1.00 0.60 ? 161 LEU A CB  1 
ATOM 1239 C CG  . LEU A 1 161 ? 44.312 36.449 37.983 1.00 0.60 ? 161 LEU A CG  1 
ATOM 1240 C CD1 . LEU A 1 161 ? 45.394 35.635 38.716 1.00 0.60 ? 161 LEU A CD1 1 
ATOM 1241 C CD2 . LEU A 1 161 ? 43.002 35.648 37.919 1.00 0.60 ? 161 LEU A CD2 1 
ATOM 1242 N N   . PRO A 1 162 ? 41.843 40.222 39.459 1.00 0.58 ? 162 PRO A N   1 
ATOM 1243 C CA  . PRO A 1 162 ? 41.553 41.436 40.228 1.00 0.58 ? 162 PRO A CA  1 
ATOM 1244 C C   . PRO A 1 162 ? 42.029 41.281 41.667 1.00 0.58 ? 162 PRO A C   1 
ATOM 1245 O O   . PRO A 1 162 ? 41.290 41.557 42.609 1.00 0.58 ? 162 PRO A O   1 
ATOM 1246 C CB  . PRO A 1 162 ? 40.015 41.532 40.144 1.00 0.58 ? 162 PRO A CB  1 
ATOM 1247 C CG  . PRO A 1 162 ? 39.541 40.082 40.031 1.00 0.58 ? 162 PRO A CG  1 
ATOM 1248 C CD  . PRO A 1 162 ? 40.640 39.431 39.199 1.00 0.58 ? 162 PRO A CD  1 
ATOM 1249 N N   . GLN A 1 163 ? 43.287 40.831 41.844 1.00 0.49 ? 163 GLN A N   1 
ATOM 1250 C CA  . GLN A 1 163 ? 43.949 40.558 43.112 1.00 0.49 ? 163 GLN A CA  1 
ATOM 1251 C C   . GLN A 1 163 ? 43.233 39.533 44.004 1.00 0.49 ? 163 GLN A C   1 
ATOM 1252 O O   . GLN A 1 163 ? 43.437 39.480 45.220 1.00 0.49 ? 163 GLN A O   1 
ATOM 1253 C CB  . GLN A 1 163 ? 44.300 41.864 43.878 1.00 0.49 ? 163 GLN A CB  1 
ATOM 1254 C CG  . GLN A 1 163 ? 45.130 42.872 43.046 1.00 0.49 ? 163 GLN A CG  1 
ATOM 1255 C CD  . GLN A 1 163 ? 45.516 44.111 43.856 1.00 0.49 ? 163 GLN A CD  1 
ATOM 1256 O OE1 . GLN A 1 163 ? 44.856 45.149 43.829 1.00 0.49 ? 163 GLN A OE1 1 
ATOM 1257 N NE2 . GLN A 1 163 ? 46.641 44.015 44.602 1.00 0.49 ? 163 GLN A NE2 1 
ATOM 1258 N N   . GLY A 1 164 ? 42.402 38.652 43.413 1.00 0.54 ? 164 GLY A N   1 
ATOM 1259 C CA  . GLY A 1 164 ? 41.548 37.729 44.137 1.00 0.54 ? 164 GLY A CA  1 
ATOM 1260 C C   . GLY A 1 164 ? 40.637 37.062 43.149 1.00 0.54 ? 164 GLY A C   1 
ATOM 1261 O O   . GLY A 1 164 ? 40.744 37.317 41.952 1.00 0.54 ? 164 GLY A O   1 
ATOM 1262 N N   . THR A 1 165 ? 39.739 36.177 43.644 1.00 0.52 ? 165 THR A N   1 
ATOM 1263 C CA  . THR A 1 165 ? 38.718 35.429 42.888 1.00 0.52 ? 165 THR A CA  1 
ATOM 1264 C C   . THR A 1 165 ? 39.285 34.689 41.686 1.00 0.52 ? 165 THR A C   1 
ATOM 1265 O O   . THR A 1 165 ? 38.834 34.811 40.549 1.00 0.52 ? 165 THR A O   1 
ATOM 1266 C CB  . THR A 1 165 ? 37.470 36.251 42.576 1.00 0.52 ? 165 THR A CB  1 
ATOM 1267 O OG1 . THR A 1 165 ? 37.002 36.851 43.778 1.00 0.52 ? 165 THR A OG1 1 
ATOM 1268 C CG2 . THR A 1 165 ? 36.271 35.426 42.085 1.00 0.52 ? 165 THR A CG2 1 
ATOM 1269 N N   . THR A 1 166 ? 40.354 33.900 41.917 1.00 0.56 ? 166 THR A N   1 
ATOM 1270 C CA  . THR A 1 166 ? 41.137 33.307 40.845 1.00 0.56 ? 166 THR A CA  1 
ATOM 1271 C C   . THR A 1 166 ? 40.546 32.013 40.321 1.00 0.56 ? 166 THR A C   1 
ATOM 1272 O O   . THR A 1 166 ? 39.749 31.333 40.966 1.00 0.56 ? 166 THR A O   1 
ATOM 1273 C CB  . THR A 1 166 ? 42.618 33.081 41.188 1.00 0.56 ? 166 THR A CB  1 
ATOM 1274 O OG1 . THR A 1 166 ? 42.814 32.043 42.135 1.00 0.56 ? 166 THR A OG1 1 
ATOM 1275 C CG2 . THR A 1 166 ? 43.223 34.353 41.806 1.00 0.56 ? 166 THR A CG2 1 
ATOM 1276 N N   . LEU A 1 167 ? 40.921 31.645 39.082 1.00 0.54 ? 167 LEU A N   1 
ATOM 1277 C CA  . LEU A 1 167 ? 40.657 30.340 38.508 1.00 0.54 ? 167 LEU A CA  1 
ATOM 1278 C C   . LEU A 1 167 ? 41.398 29.194 39.210 1.00 0.54 ? 167 LEU A C   1 
ATOM 1279 O O   . LEU A 1 167 ? 42.488 29.415 39.742 1.00 0.54 ? 167 LEU A O   1 
ATOM 1280 C CB  . LEU A 1 167 ? 41.040 30.355 37.013 1.00 0.54 ? 167 LEU A CB  1 
ATOM 1281 C CG  . LEU A 1 167 ? 40.087 31.199 36.152 1.00 0.54 ? 167 LEU A CG  1 
ATOM 1282 C CD1 . LEU A 1 167 ? 40.751 31.549 34.815 1.00 0.54 ? 167 LEU A CD1 1 
ATOM 1283 C CD2 . LEU A 1 167 ? 38.743 30.473 35.939 1.00 0.54 ? 167 LEU A CD2 1 
ATOM 1284 N N   . PRO A 1 168 ? 40.863 27.971 39.259 1.00 0.42 ? 168 PRO A N   1 
ATOM 1285 C CA  . PRO A 1 168 ? 41.506 26.849 39.927 1.00 0.42 ? 168 PRO A CA  1 
ATOM 1286 C C   . PRO A 1 168 ? 42.796 26.375 39.276 1.00 0.42 ? 168 PRO A C   1 
ATOM 1287 O O   . PRO A 1 168 ? 43.220 26.866 38.233 1.00 0.42 ? 168 PRO A O   1 
ATOM 1288 C CB  . PRO A 1 168 ? 40.418 25.764 39.949 1.00 0.42 ? 168 PRO A CB  1 
ATOM 1289 C CG  . PRO A 1 168 ? 39.574 26.055 38.713 1.00 0.42 ? 168 PRO A CG  1 
ATOM 1290 C CD  . PRO A 1 168 ? 39.597 27.577 38.630 1.00 0.42 ? 168 PRO A CD  1 
ATOM 1291 N N   . LYS A 1 169 ? 43.441 25.386 39.925 1.00 0.35 ? 169 LYS A N   1 
ATOM 1292 C CA  . LYS A 1 169 ? 44.833 24.995 39.768 1.00 0.35 ? 169 LYS A CA  1 
ATOM 1293 C C   . LYS A 1 169 ? 45.309 24.567 38.380 1.00 0.35 ? 169 LYS A C   1 
ATOM 1294 O O   . LYS A 1 169 ? 46.503 24.602 38.096 1.00 0.35 ? 169 LYS A O   1 
ATOM 1295 C CB  . LYS A 1 169 ? 45.132 23.867 40.789 1.00 0.35 ? 169 LYS A CB  1 
ATOM 1296 C CG  . LYS A 1 169 ? 46.624 23.584 41.045 1.00 0.35 ? 169 LYS A CG  1 
ATOM 1297 C CD  . LYS A 1 169 ? 46.869 22.439 42.045 1.00 0.35 ? 169 LYS A CD  1 
ATOM 1298 C CE  . LYS A 1 169 ? 46.389 22.749 43.467 1.00 0.35 ? 169 LYS A CE  1 
ATOM 1299 N NZ  . LYS A 1 169 ? 46.625 21.593 44.364 1.00 0.35 ? 169 LYS A NZ  1 
ATOM 1300 N N   . GLY A 1 170 ? 44.401 24.145 37.477 1.00 0.45 ? 170 GLY A N   1 
ATOM 1301 C CA  . GLY A 1 170 ? 44.773 23.810 36.106 1.00 0.45 ? 170 GLY A CA  1 
ATOM 1302 C C   . GLY A 1 170 ? 45.178 24.996 35.262 1.00 0.45 ? 170 GLY A C   1 
ATOM 1303 O O   . GLY A 1 170 ? 46.102 24.923 34.458 1.00 0.45 ? 170 GLY A O   1 
ATOM 1304 N N   . PHE A 1 171 ? 44.470 26.125 35.422 1.00 0.47 ? 171 PHE A N   1 
ATOM 1305 C CA  . PHE A 1 171 ? 44.545 27.250 34.512 1.00 0.47 ? 171 PHE A CA  1 
ATOM 1306 C C   . PHE A 1 171 ? 45.855 28.044 34.497 1.00 0.47 ? 171 PHE A C   1 
ATOM 1307 O O   . PHE A 1 171 ? 46.341 28.560 35.503 1.00 0.47 ? 171 PHE A O   1 
ATOM 1308 C CB  . PHE A 1 171 ? 43.386 28.253 34.760 1.00 0.47 ? 171 PHE A CB  1 
ATOM 1309 C CG  . PHE A 1 171 ? 42.022 27.699 34.417 1.00 0.47 ? 171 PHE A CG  1 
ATOM 1310 C CD1 . PHE A 1 171 ? 41.309 26.882 35.312 1.00 0.47 ? 171 PHE A CD1 1 
ATOM 1311 C CD2 . PHE A 1 171 ? 41.393 28.083 33.221 1.00 0.47 ? 171 PHE A CD2 1 
ATOM 1312 C CE1 . PHE A 1 171 ? 39.999 26.475 35.031 1.00 0.47 ? 171 PHE A CE1 1 
ATOM 1313 C CE2 . PHE A 1 171 ? 40.079 27.685 32.944 1.00 0.47 ? 171 PHE A CE2 1 
ATOM 1314 C CZ  . PHE A 1 171 ? 39.379 26.890 33.853 1.00 0.47 ? 171 PHE A CZ  1 
ATOM 1315 N N   . TYR A 1 172 ? 46.404 28.269 33.283 1.00 0.44 ? 172 TYR A N   1 
ATOM 1316 C CA  . TYR A 1 172 ? 47.333 29.349 33.014 1.00 0.44 ? 172 TYR A CA  1 
ATOM 1317 C C   . TYR A 1 172 ? 46.470 30.596 32.835 1.00 0.44 ? 172 TYR A C   1 
ATOM 1318 O O   . TYR A 1 172 ? 45.775 30.730 31.830 1.00 0.44 ? 172 TYR A O   1 
ATOM 1319 C CB  . TYR A 1 172 ? 48.165 29.022 31.731 1.00 0.44 ? 172 TYR A CB  1 
ATOM 1320 C CG  . TYR A 1 172 ? 49.269 29.997 31.399 1.00 0.44 ? 172 TYR A CG  1 
ATOM 1321 C CD1 . TYR A 1 172 ? 48.986 31.268 30.872 1.00 0.44 ? 172 TYR A CD1 1 
ATOM 1322 C CD2 . TYR A 1 172 ? 50.614 29.633 31.573 1.00 0.44 ? 172 TYR A CD2 1 
ATOM 1323 C CE1 . TYR A 1 172 ? 50.010 32.191 30.623 1.00 0.44 ? 172 TYR A CE1 1 
ATOM 1324 C CE2 . TYR A 1 172 ? 51.643 30.545 31.303 1.00 0.44 ? 172 TYR A CE2 1 
ATOM 1325 C CZ  . TYR A 1 172 ? 51.339 31.837 30.859 1.00 0.44 ? 172 TYR A CZ  1 
ATOM 1326 O OH  . TYR A 1 172 ? 52.382 32.749 30.607 1.00 0.44 ? 172 TYR A OH  1 
ATOM 1327 N N   . ALA A 1 173 ? 46.460 31.489 33.853 1.00 0.63 ? 173 ALA A N   1 
ATOM 1328 C CA  . ALA A 1 173 ? 45.754 32.765 33.896 1.00 0.63 ? 173 ALA A CA  1 
ATOM 1329 C C   . ALA A 1 173 ? 46.112 33.737 32.772 1.00 0.63 ? 173 ALA A C   1 
ATOM 1330 O O   . ALA A 1 173 ? 47.003 33.474 31.973 1.00 0.63 ? 173 ALA A O   1 
ATOM 1331 C CB  . ALA A 1 173 ? 45.956 33.414 35.284 1.00 0.63 ? 173 ALA A CB  1 
ATOM 1332 N N   . GLU A 1 174 ? 45.443 34.910 32.688 1.00 0.61 ? 174 GLU A N   1 
ATOM 1333 C CA  . GLU A 1 174 ? 45.477 35.810 31.549 1.00 0.61 ? 174 GLU A CA  1 
ATOM 1334 C C   . GLU A 1 174 ? 46.876 36.184 31.080 1.00 0.61 ? 174 GLU A C   1 
ATOM 1335 O O   . GLU A 1 174 ? 47.210 36.060 29.910 1.00 0.61 ? 174 GLU A O   1 
ATOM 1336 C CB  . GLU A 1 174 ? 44.642 37.092 31.822 1.00 0.61 ? 174 GLU A CB  1 
ATOM 1337 C CG  . GLU A 1 174 ? 43.125 36.835 31.991 1.00 0.61 ? 174 GLU A CG  1 
ATOM 1338 C CD  . GLU A 1 174 ? 42.738 36.405 33.408 1.00 0.61 ? 174 GLU A CD  1 
ATOM 1339 O OE1 . GLU A 1 174 ? 43.646 36.113 34.234 1.00 0.61 ? 174 GLU A OE1 1 
ATOM 1340 O OE2 . GLU A 1 174 ? 41.518 36.382 33.679 1.00 0.61 ? 174 GLU A OE2 1 
ATOM 1341 N N   . GLY A 1 175 ? 47.800 36.573 31.972 1.00 0.61 ? 175 GLY A N   1 
ATOM 1342 C CA  . GLY A 1 175 ? 49.206 36.466 31.574 1.00 0.61 ? 175 GLY A CA  1 
ATOM 1343 C C   . GLY A 1 175 ? 49.813 37.542 30.712 1.00 0.61 ? 175 GLY A C   1 
ATOM 1344 O O   . GLY A 1 175 ? 50.609 37.258 29.815 1.00 0.61 ? 175 GLY A O   1 
ATOM 1345 N N   . SER A 1 176 ? 49.501 38.823 31.009 1.00 0.55 ? 176 SER A N   1 
ATOM 1346 C CA  . SER A 1 176 ? 50.205 39.980 30.457 1.00 0.55 ? 176 SER A CA  1 
ATOM 1347 C C   . SER A 1 176 ? 51.717 39.921 30.671 1.00 0.55 ? 176 SER A C   1 
ATOM 1348 O O   . SER A 1 176 ? 52.197 39.600 31.760 1.00 0.55 ? 176 SER A O   1 
ATOM 1349 C CB  . SER A 1 176 ? 49.679 41.333 31.017 1.00 0.55 ? 176 SER A CB  1 
ATOM 1350 O OG  . SER A 1 176 ? 50.329 42.451 30.411 1.00 0.55 ? 176 SER A OG  1 
ATOM 1351 N N   . ARG A 1 177 ? 52.483 40.220 29.602 1.00 0.46 ? 177 ARG A N   1 
ATOM 1352 C CA  . ARG A 1 177 ? 53.924 40.132 29.557 1.00 0.46 ? 177 ARG A CA  1 
ATOM 1353 C C   . ARG A 1 177 ? 54.409 41.185 28.585 1.00 0.46 ? 177 ARG A C   1 
ATOM 1354 O O   . ARG A 1 177 ? 53.763 41.436 27.569 1.00 0.46 ? 177 ARG A O   1 
ATOM 1355 C CB  . ARG A 1 177 ? 54.418 38.763 29.014 1.00 0.46 ? 177 ARG A CB  1 
ATOM 1356 C CG  . ARG A 1 177 ? 54.266 37.600 30.013 1.00 0.46 ? 177 ARG A CG  1 
ATOM 1357 C CD  . ARG A 1 177 ? 54.657 36.229 29.455 1.00 0.46 ? 177 ARG A CD  1 
ATOM 1358 N NE  . ARG A 1 177 ? 53.585 35.833 28.485 1.00 0.46 ? 177 ARG A NE  1 
ATOM 1359 C CZ  . ARG A 1 177 ? 53.777 35.531 27.195 1.00 0.46 ? 177 ARG A CZ  1 
ATOM 1360 N NH1 . ARG A 1 177 ? 52.713 35.378 26.407 1.00 0.46 ? 177 ARG A NH1 1 
ATOM 1361 N NH2 . ARG A 1 177 ? 54.992 35.375 26.677 1.00 0.46 ? 177 ARG A NH2 1 
ATOM 1362 N N   . GLY A 1 178 ? 55.591 41.780 28.860 1.00 0.35 ? 178 GLY A N   1 
ATOM 1363 C CA  . GLY A 1 178 ? 56.106 42.977 28.188 1.00 0.35 ? 178 GLY A CA  1 
ATOM 1364 C C   . GLY A 1 178 ? 56.237 42.977 26.687 1.00 0.35 ? 178 GLY A C   1 
ATOM 1365 O O   . GLY A 1 178 ? 56.119 44.019 26.055 1.00 0.35 ? 178 GLY A O   1 
ATOM 1366 N N   . GLY A 1 179 ? 56.514 41.805 26.083 1.00 0.39 ? 179 GLY A N   1 
ATOM 1367 C CA  . GLY A 1 179 ? 56.631 41.663 24.637 1.00 0.39 ? 179 GLY A CA  1 
ATOM 1368 C C   . GLY A 1 179 ? 55.414 41.088 23.977 1.00 0.39 ? 179 GLY A C   1 
ATOM 1369 O O   . GLY A 1 179 ? 55.366 40.972 22.758 1.00 0.39 ? 179 GLY A O   1 
ATOM 1370 N N   . SER A 1 180 ? 54.390 40.694 24.759 1.00 0.40 ? 180 SER A N   1 
ATOM 1371 C CA  . SER A 1 180 ? 53.101 40.306 24.202 1.00 0.40 ? 180 SER A CA  1 
ATOM 1372 C C   . SER A 1 180 ? 52.291 41.560 23.935 1.00 0.40 ? 180 SER A C   1 
ATOM 1373 O O   . SER A 1 180 ? 51.797 41.774 22.834 1.00 0.40 ? 180 SER A O   1 
ATOM 1374 C CB  . SER A 1 180 ? 52.342 39.328 25.149 1.00 0.40 ? 180 SER A CB  1 
ATOM 1375 O OG  . SER A 1 180 ? 51.125 38.823 24.594 1.00 0.40 ? 180 SER A OG  1 
ATOM 1376 N N   . GLN A 1 181 ? 52.187 42.476 24.920 1.00 0.50 ? 181 GLN A N   1 
ATOM 1377 C CA  . GLN A 1 181 ? 51.561 43.760 24.688 1.00 0.50 ? 181 GLN A CA  1 
ATOM 1378 C C   . GLN A 1 181 ? 52.090 44.758 25.696 1.00 0.50 ? 181 GLN A C   1 
ATOM 1379 O O   . GLN A 1 181 ? 52.369 44.411 26.841 1.00 0.50 ? 181 GLN A O   1 
ATOM 1380 C CB  . GLN A 1 181 ? 50.012 43.698 24.790 1.00 0.50 ? 181 GLN A CB  1 
ATOM 1381 C CG  . GLN A 1 181 ? 49.540 42.782 25.947 1.00 0.50 ? 181 GLN A CG  1 
ATOM 1382 C CD  . GLN A 1 181 ? 48.049 42.812 26.309 1.00 0.50 ? 181 GLN A CD  1 
ATOM 1383 O OE1 . GLN A 1 181 ? 47.681 42.258 27.346 1.00 0.50 ? 181 GLN A OE1 1 
ATOM 1384 N NE2 . GLN A 1 181 ? 47.178 43.420 25.484 1.00 0.50 ? 181 GLN A NE2 1 
ATOM 1385 N N   . ALA A 1 182 ? 52.226 46.037 25.285 1.00 0.51 ? 182 ALA A N   1 
ATOM 1386 C CA  . ALA A 1 182 ? 52.872 47.044 26.104 1.00 0.51 ? 182 ALA A CA  1 
ATOM 1387 C C   . ALA A 1 182 ? 52.095 48.351 26.263 1.00 0.51 ? 182 ALA A C   1 
ATOM 1388 O O   . ALA A 1 182 ? 52.420 49.171 27.115 1.00 0.51 ? 182 ALA A O   1 
ATOM 1389 C CB  . ALA A 1 182 ? 54.207 47.385 25.424 1.00 0.51 ? 182 ALA A CB  1 
ATOM 1390 N N   . SER A 1 183 ? 51.059 48.607 25.444 1.00 0.55 ? 183 SER A N   1 
ATOM 1391 C CA  . SER A 1 183 ? 50.473 49.942 25.343 1.00 0.55 ? 183 SER A CA  1 
ATOM 1392 C C   . SER A 1 183 ? 49.492 50.333 26.432 1.00 0.55 ? 183 SER A C   1 
ATOM 1393 O O   . SER A 1 183 ? 49.177 51.507 26.617 1.00 0.55 ? 183 SER A O   1 
ATOM 1394 C CB  . SER A 1 183 ? 49.714 50.112 24.011 1.00 0.55 ? 183 SER A CB  1 
ATOM 1395 O OG  . SER A 1 183 ? 50.488 49.572 22.936 1.00 0.55 ? 183 SER A OG  1 
ATOM 1396 N N   . SER A 1 184 ? 48.963 49.345 27.165 1.00 0.61 ? 184 SER A N   1 
ATOM 1397 C CA  . SER A 1 184 ? 48.133 49.552 28.341 1.00 0.61 ? 184 SER A CA  1 
ATOM 1398 C C   . SER A 1 184 ? 48.972 49.863 29.568 1.00 0.61 ? 184 SER A C   1 
ATOM 1399 O O   . SER A 1 184 ? 50.092 49.384 29.725 1.00 0.61 ? 184 SER A O   1 
ATOM 1400 C CB  . SER A 1 184 ? 47.311 48.282 28.659 1.00 0.61 ? 184 SER A CB  1 
ATOM 1401 O OG  . SER A 1 184 ? 46.274 48.489 29.619 1.00 0.61 ? 184 SER A OG  1 
ATOM 1402 N N   . ARG A 1 185 ? 48.436 50.663 30.507 1.00 0.58 ? 185 ARG A N   1 
ATOM 1403 C CA  . ARG A 1 185 ? 48.999 50.792 31.837 1.00 0.58 ? 185 ARG A CA  1 
ATOM 1404 C C   . ARG A 1 185 ? 48.851 49.507 32.642 1.00 0.58 ? 185 ARG A C   1 
ATOM 1405 O O   . ARG A 1 185 ? 47.915 48.730 32.472 1.00 0.58 ? 185 ARG A O   1 
ATOM 1406 C CB  . ARG A 1 185 ? 48.350 51.944 32.647 1.00 0.58 ? 185 ARG A CB  1 
ATOM 1407 C CG  . ARG A 1 185 ? 48.512 53.334 31.999 1.00 0.58 ? 185 ARG A CG  1 
ATOM 1408 C CD  . ARG A 1 185 ? 47.870 54.496 32.772 1.00 0.58 ? 185 ARG A CD  1 
ATOM 1409 N NE  . ARG A 1 185 ? 48.707 54.749 33.991 1.00 0.58 ? 185 ARG A NE  1 
ATOM 1410 C CZ  . ARG A 1 185 ? 48.585 55.824 34.783 1.00 0.58 ? 185 ARG A CZ  1 
ATOM 1411 N NH1 . ARG A 1 185 ? 49.479 56.046 35.746 1.00 0.58 ? 185 ARG A NH1 1 
ATOM 1412 N NH2 . ARG A 1 185 ? 47.613 56.709 34.601 1.00 0.58 ? 185 ARG A NH2 1 
ATOM 1413 N N   . SER A 1 186 ? 49.761 49.269 33.604 1.00 0.63 ? 186 SER A N   1 
ATOM 1414 C CA  . SER A 1 186 ? 49.762 48.055 34.407 1.00 0.63 ? 186 SER A CA  1 
ATOM 1415 C C   . SER A 1 186 ? 48.617 47.956 35.413 1.00 0.63 ? 186 SER A C   1 
ATOM 1416 O O   . SER A 1 186 ? 48.271 46.868 35.871 1.00 0.63 ? 186 SER A O   1 
ATOM 1417 C CB  . SER A 1 186 ? 51.107 47.933 35.166 1.00 0.63 ? 186 SER A CB  1 
ATOM 1418 O OG  . SER A 1 186 ? 51.387 49.104 35.941 1.00 0.63 ? 186 SER A OG  1 
ATOM 1419 N N   . SER A 1 187 ? 48.009 49.107 35.771 1.00 0.64 ? 187 SER A N   1 
ATOM 1420 C CA  . SER A 1 187 ? 46.809 49.232 36.593 1.00 0.64 ? 187 SER A CA  1 
ATOM 1421 C C   . SER A 1 187 ? 47.047 48.982 38.084 1.00 0.64 ? 187 SER A C   1 
ATOM 1422 O O   . SER A 1 187 ? 46.125 48.945 38.889 1.00 0.64 ? 187 SER A O   1 
ATOM 1423 C CB  . SER A 1 187 ? 45.575 48.516 35.956 1.00 0.64 ? 187 SER A CB  1 
ATOM 1424 O OG  . SER A 1 187 ? 44.300 48.947 36.439 1.00 0.64 ? 187 SER A OG  1 
ATOM 1425 N N   . SER A 1 188 ? 48.331 48.967 38.528 1.00 0.64 ? 188 SER A N   1 
ATOM 1426 C CA  . SER A 1 188 ? 48.734 48.862 39.937 1.00 0.64 ? 188 SER A CA  1 
ATOM 1427 C C   . SER A 1 188 ? 48.519 50.141 40.736 1.00 0.64 ? 188 SER A C   1 
ATOM 1428 O O   . SER A 1 188 ? 48.656 50.186 41.957 1.00 0.64 ? 188 SER A O   1 
ATOM 1429 C CB  . SER A 1 188 ? 50.226 48.472 40.069 1.00 0.64 ? 188 SER A CB  1 
ATOM 1430 O OG  . SER A 1 188 ? 51.110 49.409 39.442 1.00 0.64 ? 188 SER A OG  1 
ATOM 1431 N N   . ARG A 1 189 ? 48.166 51.212 40.004 1.00 0.59 ? 189 ARG A N   1 
ATOM 1432 C CA  . ARG A 1 189 ? 47.769 52.534 40.439 1.00 0.59 ? 189 ARG A CA  1 
ATOM 1433 C C   . ARG A 1 189 ? 46.576 52.565 41.372 1.00 0.59 ? 189 ARG A C   1 
ATOM 1434 O O   . ARG A 1 189 ? 46.499 53.438 42.234 1.00 0.59 ? 189 ARG A O   1 
ATOM 1435 C CB  . ARG A 1 189 ? 47.386 53.334 39.161 1.00 0.59 ? 189 ARG A CB  1 
ATOM 1436 C CG  . ARG A 1 189 ? 46.877 54.784 39.366 1.00 0.59 ? 189 ARG A CG  1 
ATOM 1437 C CD  . ARG A 1 189 ? 46.442 55.499 38.077 1.00 0.59 ? 189 ARG A CD  1 
ATOM 1438 N NE  . ARG A 1 189 ? 45.216 54.814 37.519 1.00 0.59 ? 189 ARG A NE  1 
ATOM 1439 C CZ  . ARG A 1 189 ? 43.942 55.188 37.725 1.00 0.59 ? 189 ARG A CZ  1 
ATOM 1440 N NH1 . ARG A 1 189 ? 42.945 54.451 37.236 1.00 0.59 ? 189 ARG A NH1 1 
ATOM 1441 N NH2 . ARG A 1 189 ? 43.645 56.282 38.414 1.00 0.59 ? 189 ARG A NH2 1 
ATOM 1442 N N   . SER A 1 190 ? 45.600 51.658 41.174 1.00 0.58 ? 190 SER A N   1 
ATOM 1443 C CA  . SER A 1 190 ? 44.387 51.669 41.961 1.00 0.58 ? 190 SER A CA  1 
ATOM 1444 C C   . SER A 1 190 ? 44.046 50.249 42.325 1.00 0.58 ? 190 SER A C   1 
ATOM 1445 O O   . SER A 1 190 ? 43.593 49.483 41.478 1.00 0.58 ? 190 SER A O   1 
ATOM 1446 C CB  . SER A 1 190 ? 43.184 52.251 41.176 1.00 0.58 ? 190 SER A CB  1 
ATOM 1447 O OG  . SER A 1 190 ? 43.410 53.608 40.783 1.00 0.58 ? 190 SER A OG  1 
ATOM 1448 N N   . ARG A 1 191 ? 44.265 49.856 43.595 1.00 0.59 ? 191 ARG A N   1 
ATOM 1449 C CA  . ARG A 1 191 ? 44.016 48.503 44.070 1.00 0.59 ? 191 ARG A CA  1 
ATOM 1450 C C   . ARG A 1 191 ? 42.584 47.980 43.974 1.00 0.59 ? 191 ARG A C   1 
ATOM 1451 O O   . ARG A 1 191 ? 41.607 48.688 44.218 1.00 0.59 ? 191 ARG A O   1 
ATOM 1452 C CB  . ARG A 1 191 ? 44.533 48.304 45.520 1.00 0.59 ? 191 ARG A CB  1 
ATOM 1453 C CG  . ARG A 1 191 ? 43.852 49.171 46.604 1.00 0.59 ? 191 ARG A CG  1 
ATOM 1454 C CD  . ARG A 1 191 ? 44.396 48.879 48.007 1.00 0.59 ? 191 ARG A CD  1 
ATOM 1455 N NE  . ARG A 1 191 ? 43.833 49.904 48.957 1.00 0.59 ? 191 ARG A NE  1 
ATOM 1456 C CZ  . ARG A 1 191 ? 44.457 51.035 49.317 1.00 0.59 ? 191 ARG A CZ  1 
ATOM 1457 N NH1 . ARG A 1 191 ? 43.850 51.887 50.143 1.00 0.59 ? 191 ARG A NH1 1 
ATOM 1458 N NH2 . ARG A 1 191 ? 45.668 51.349 48.878 1.00 0.59 ? 191 ARG A NH2 1 
ATOM 1459 N N   . ASN A 1 192 ? 42.439 46.681 43.639 1.00 0.61 ? 192 ASN A N   1 
ATOM 1460 C CA  . ASN A 1 192 ? 41.160 46.002 43.595 1.00 0.61 ? 192 ASN A CA  1 
ATOM 1461 C C   . ASN A 1 192 ? 40.666 45.623 44.988 1.00 0.61 ? 192 ASN A C   1 
ATOM 1462 O O   . ASN A 1 192 ? 41.435 45.457 45.935 1.00 0.61 ? 192 ASN A O   1 
ATOM 1463 C CB  . ASN A 1 192 ? 41.229 44.709 42.747 1.00 0.61 ? 192 ASN A CB  1 
ATOM 1464 C CG  . ASN A 1 192 ? 41.567 44.999 41.291 1.00 0.61 ? 192 ASN A CG  1 
ATOM 1465 O OD1 . ASN A 1 192 ? 42.682 44.766 40.824 1.00 0.61 ? 192 ASN A OD1 1 
ATOM 1466 N ND2 . ASN A 1 192 ? 40.562 45.465 40.514 1.00 0.61 ? 192 ASN A ND2 1 
ATOM 1467 N N   . SER A 1 193 ? 39.336 45.471 45.152 1.00 0.57 ? 193 SER A N   1 
ATOM 1468 C CA  . SER A 1 193 ? 38.729 45.014 46.397 1.00 0.57 ? 193 SER A CA  1 
ATOM 1469 C C   . SER A 1 193 ? 39.056 43.566 46.736 1.00 0.57 ? 193 SER A C   1 
ATOM 1470 O O   . SER A 1 193 ? 38.468 42.640 46.181 1.00 0.57 ? 193 SER A O   1 
ATOM 1471 C CB  . SER A 1 193 ? 37.186 45.153 46.367 1.00 0.57 ? 193 SER A CB  1 
ATOM 1472 O OG  . SER A 1 193 ? 36.827 46.501 46.058 1.00 0.57 ? 193 SER A OG  1 
ATOM 1473 N N   . SER A 1 194 ? 39.992 43.323 47.673 1.00 0.62 ? 194 SER A N   1 
ATOM 1474 C CA  . SER A 1 194 ? 40.422 41.980 48.029 1.00 0.62 ? 194 SER A CA  1 
ATOM 1475 C C   . SER A 1 194 ? 40.932 41.991 49.452 1.00 0.62 ? 194 SER A C   1 
ATOM 1476 O O   . SER A 1 194 ? 41.383 43.019 49.949 1.00 0.62 ? 194 SER A O   1 
ATOM 1477 C CB  . SER A 1 194 ? 41.551 41.455 47.095 1.00 0.62 ? 194 SER A CB  1 
ATOM 1478 O OG  . SER A 1 194 ? 42.053 40.158 47.451 1.00 0.62 ? 194 SER A OG  1 
ATOM 1479 N N   . ARG A 1 195 ? 40.853 40.830 50.134 1.00 0.61 ? 195 ARG A N   1 
ATOM 1480 C CA  . ARG A 1 195 ? 41.345 40.627 51.480 1.00 0.61 ? 195 ARG A CA  1 
ATOM 1481 C C   . ARG A 1 195 ? 42.478 39.615 51.534 1.00 0.61 ? 195 ARG A C   1 
ATOM 1482 O O   . ARG A 1 195 ? 42.830 39.152 52.617 1.00 0.61 ? 195 ARG A O   1 
ATOM 1483 C CB  . ARG A 1 195 ? 40.210 40.079 52.394 1.00 0.61 ? 195 ARG A CB  1 
ATOM 1484 C CG  . ARG A 1 195 ? 39.637 38.686 52.025 1.00 0.61 ? 195 ARG A CG  1 
ATOM 1485 C CD  . ARG A 1 195 ? 38.512 38.248 52.974 1.00 0.61 ? 195 ARG A CD  1 
ATOM 1486 N NE  . ARG A 1 195 ? 37.954 36.931 52.497 1.00 0.61 ? 195 ARG A NE  1 
ATOM 1487 C CZ  . ARG A 1 195 ? 38.320 35.722 52.951 1.00 0.61 ? 195 ARG A CZ  1 
ATOM 1488 N NH1 . ARG A 1 195 ? 37.675 34.639 52.518 1.00 0.61 ? 195 ARG A NH1 1 
ATOM 1489 N NH2 . ARG A 1 195 ? 39.306 35.573 53.829 1.00 0.61 ? 195 ARG A NH2 1 
ATOM 1490 N N   . ASN A 1 196 ? 43.032 39.182 50.379 1.00 0.71 ? 196 ASN A N   1 
ATOM 1491 C CA  . ASN A 1 196 ? 43.867 37.990 50.345 1.00 0.71 ? 196 ASN A CA  1 
ATOM 1492 C C   . ASN A 1 196 ? 45.361 38.247 50.221 1.00 0.71 ? 196 ASN A C   1 
ATOM 1493 O O   . ASN A 1 196 ? 46.141 37.307 50.127 1.00 0.71 ? 196 ASN A O   1 
ATOM 1494 C CB  . ASN A 1 196 ? 43.377 37.095 49.177 1.00 0.71 ? 196 ASN A CB  1 
ATOM 1495 C CG  . ASN A 1 196 ? 43.705 35.631 49.425 1.00 0.71 ? 196 ASN A CG  1 
ATOM 1496 O OD1 . ASN A 1 196 ? 43.578 35.148 50.550 1.00 0.71 ? 196 ASN A OD1 1 
ATOM 1497 N ND2 . ASN A 1 196 ? 44.046 34.877 48.360 1.00 0.71 ? 196 ASN A ND2 1 
ATOM 1498 N N   . SER A 1 197 ? 45.808 39.516 50.202 1.00 0.72 ? 197 SER A N   1 
ATOM 1499 C CA  . SER A 1 197 ? 47.214 39.855 50.427 1.00 0.72 ? 197 SER A CA  1 
ATOM 1500 C C   . SER A 1 197 ? 48.218 39.340 49.395 1.00 0.72 ? 197 SER A C   1 
ATOM 1501 O O   . SER A 1 197 ? 49.379 39.079 49.714 1.00 0.72 ? 197 SER A O   1 
ATOM 1502 C CB  . SER A 1 197 ? 47.727 39.374 51.813 1.00 0.72 ? 197 SER A CB  1 
ATOM 1503 O OG  . SER A 1 197 ? 46.747 39.398 52.850 1.00 0.72 ? 197 SER A OG  1 
ATOM 1504 N N   . THR A 1 198 ? 47.796 39.164 48.123 1.00 0.77 ? 198 THR A N   1 
ATOM 1505 C CA  . THR A 1 198 ? 48.622 38.697 46.991 1.00 0.77 ? 198 THR A CA  1 
ATOM 1506 C C   . THR A 1 198 ? 49.542 37.481 47.245 1.00 0.77 ? 198 THR A C   1 
ATOM 1507 O O   . THR A 1 198 ? 50.772 37.600 47.168 1.00 0.77 ? 198 THR A O   1 
ATOM 1508 C CB  . THR A 1 198 ? 49.343 39.823 46.233 1.00 0.77 ? 198 THR A CB  1 
ATOM 1509 O OG1 . THR A 1 198 ? 49.981 40.745 47.104 1.00 0.77 ? 198 THR A OG1 1 
ATOM 1510 C CG2 . THR A 1 198 ? 48.297 40.634 45.442 1.00 0.77 ? 198 THR A CG2 1 
ATOM 1511 N N   . PRO A 1 199 ? 49.025 36.285 47.576 1.00 0.75 ? 199 PRO A N   1 
ATOM 1512 C CA  . PRO A 1 199 ? 49.826 35.087 47.841 1.00 0.75 ? 199 PRO A CA  1 
ATOM 1513 C C   . PRO A 1 199 ? 50.688 34.579 46.694 1.00 0.75 ? 199 PRO A C   1 
ATOM 1514 O O   . PRO A 1 199 ? 50.486 34.965 45.544 1.00 0.75 ? 199 PRO A O   1 
ATOM 1515 C CB  . PRO A 1 199 ? 48.798 34.008 48.237 1.00 0.75 ? 199 PRO A CB  1 
ATOM 1516 C CG  . PRO A 1 199 ? 47.521 34.777 48.544 1.00 0.75 ? 199 PRO A CG  1 
ATOM 1517 C CD  . PRO A 1 199 ? 47.600 35.948 47.578 1.00 0.75 ? 199 PRO A CD  1 
ATOM 1518 N N   . GLY A 1 200 ? 51.663 33.692 47.004 1.00 0.75 ? 200 GLY A N   1 
ATOM 1519 C CA  . GLY A 1 200 ? 52.500 33.013 46.017 1.00 0.75 ? 200 GLY A CA  1 
ATOM 1520 C C   . GLY A 1 200 ? 51.975 31.667 45.585 1.00 0.75 ? 200 GLY A C   1 
ATOM 1521 O O   . GLY A 1 200 ? 50.777 31.411 45.568 1.00 0.75 ? 200 GLY A O   1 
ATOM 1522 N N   . SER A 1 201 ? 52.885 30.739 45.235 1.00 0.21 ? 201 SER A N   1 
ATOM 1523 C CA  . SER A 1 201 ? 52.521 29.396 44.813 1.00 0.21 ? 201 SER A CA  1 
ATOM 1524 C C   . SER A 1 201 ? 53.627 28.461 45.251 1.00 0.21 ? 201 SER A C   1 
ATOM 1525 O O   . SER A 1 201 ? 54.793 28.849 45.299 1.00 0.21 ? 201 SER A O   1 
ATOM 1526 C CB  . SER A 1 201 ? 52.331 29.298 43.272 1.00 0.21 ? 201 SER A CB  1 
ATOM 1527 O OG  . SER A 1 201 ? 52.216 27.941 42.808 1.00 0.21 ? 201 SER A OG  1 
ATOM 1528 N N   . SER A 1 202 ? 53.265 27.203 45.595 1.00 0.30 ? 202 SER A N   1 
ATOM 1529 C CA  . SER A 1 202 ? 54.146 26.209 46.207 1.00 0.30 ? 202 SER A CA  1 
ATOM 1530 C C   . SER A 1 202 ? 55.199 25.617 45.276 1.00 0.30 ? 202 SER A C   1 
ATOM 1531 O O   . SER A 1 202 ? 56.256 25.175 45.716 1.00 0.30 ? 202 SER A O   1 
ATOM 1532 C CB  . SER A 1 202 ? 53.313 25.067 46.855 1.00 0.30 ? 202 SER A CB  1 
ATOM 1533 O OG  . SER A 1 202 ? 54.095 24.274 47.748 1.00 0.30 ? 202 SER A OG  1 
ATOM 1534 N N   . ARG A 1 203 ? 54.964 25.626 43.944 1.00 0.34 ? 203 ARG A N   1 
ATOM 1535 C CA  . ARG A 1 203 ? 55.932 25.113 42.979 1.00 0.34 ? 203 ARG A CA  1 
ATOM 1536 C C   . ARG A 1 203 ? 57.225 25.922 42.934 1.00 0.34 ? 203 ARG A C   1 
ATOM 1537 O O   . ARG A 1 203 ? 58.324 25.379 42.909 1.00 0.34 ? 203 ARG A O   1 
ATOM 1538 C CB  . ARG A 1 203 ? 55.320 25.016 41.558 1.00 0.34 ? 203 ARG A CB  1 
ATOM 1539 C CG  . ARG A 1 203 ? 54.161 24.005 41.450 1.00 0.34 ? 203 ARG A CG  1 
ATOM 1540 C CD  . ARG A 1 203 ? 53.800 23.686 39.993 1.00 0.34 ? 203 ARG A CD  1 
ATOM 1541 N NE  . ARG A 1 203 ? 52.637 22.743 40.029 1.00 0.34 ? 203 ARG A NE  1 
ATOM 1542 C CZ  . ARG A 1 203 ? 52.371 21.855 39.061 1.00 0.34 ? 203 ARG A CZ  1 
ATOM 1543 N NH1 . ARG A 1 203 ? 51.259 21.124 39.138 1.00 0.34 ? 203 ARG A NH1 1 
ATOM 1544 N NH2 . ARG A 1 203 ? 53.162 21.658 38.018 1.00 0.34 ? 203 ARG A NH2 1 
ATOM 1545 N N   . GLY A 1 204 ? 57.116 27.266 42.951 1.00 0.35 ? 204 GLY A N   1 
ATOM 1546 C CA  . GLY A 1 204 ? 58.254 28.144 43.191 1.00 0.35 ? 204 GLY A CA  1 
ATOM 1547 C C   . GLY A 1 204 ? 59.255 28.389 42.087 1.00 0.35 ? 204 GLY A C   1 
ATOM 1548 O O   . GLY A 1 204 ? 60.202 29.135 42.313 1.00 0.35 ? 204 GLY A O   1 
ATOM 1549 N N   . THR A 1 205 ? 59.064 27.790 40.897 1.00 0.44 ? 205 THR A N   1 
ATOM 1550 C CA  . THR A 1 205 ? 59.987 27.861 39.763 1.00 0.44 ? 205 THR A CA  1 
ATOM 1551 C C   . THR A 1 205 ? 59.168 27.610 38.510 1.00 0.44 ? 205 THR A C   1 
ATOM 1552 O O   . THR A 1 205 ? 58.155 26.920 38.568 1.00 0.44 ? 205 THR A O   1 
ATOM 1553 C CB  . THR A 1 205 ? 61.117 26.822 39.861 1.00 0.44 ? 205 THR A CB  1 
ATOM 1554 O OG1 . THR A 1 205 ? 62.104 27.249 40.784 1.00 0.44 ? 205 THR A OG1 1 
ATOM 1555 C CG2 . THR A 1 205 ? 61.905 26.576 38.563 1.00 0.44 ? 205 THR A CG2 1 
ATOM 1556 N N   . SER A 1 206 ? 59.585 28.169 37.341 1.00 0.44 ? 206 SER A N   1 
ATOM 1557 C CA  . SER A 1 206 ? 58.892 28.027 36.065 1.00 0.44 ? 206 SER A CA  1 
ATOM 1558 C C   . SER A 1 206 ? 59.912 28.042 34.933 1.00 0.44 ? 206 SER A C   1 
ATOM 1559 O O   . SER A 1 206 ? 60.968 28.644 35.133 1.00 0.44 ? 206 SER A O   1 
ATOM 1560 C CB  . SER A 1 206 ? 57.971 29.229 35.749 1.00 0.44 ? 206 SER A CB  1 
ATOM 1561 O OG  . SER A 1 206 ? 56.989 29.435 36.761 1.00 0.44 ? 206 SER A OG  1 
ATOM 1562 N N   . PRO A 1 207 ? 59.699 27.454 33.741 1.00 0.40 ? 207 PRO A N   1 
ATOM 1563 C CA  . PRO A 1 207 ? 60.729 27.353 32.702 1.00 0.40 ? 207 PRO A CA  1 
ATOM 1564 C C   . PRO A 1 207 ? 60.994 28.659 31.976 1.00 0.40 ? 207 PRO A C   1 
ATOM 1565 O O   . PRO A 1 207 ? 62.148 28.957 31.678 1.00 0.40 ? 207 PRO A O   1 
ATOM 1566 C CB  . PRO A 1 207 ? 60.179 26.291 31.724 1.00 0.40 ? 207 PRO A CB  1 
ATOM 1567 C CG  . PRO A 1 207 ? 58.662 26.318 31.930 1.00 0.40 ? 207 PRO A CG  1 
ATOM 1568 C CD  . PRO A 1 207 ? 58.525 26.645 33.416 1.00 0.40 ? 207 PRO A CD  1 
ATOM 1569 N N   . ALA A 1 208 ? 59.952 29.435 31.636 1.00 0.45 ? 208 ALA A N   1 
ATOM 1570 C CA  . ALA A 1 208 ? 60.117 30.635 30.857 1.00 0.45 ? 208 ALA A CA  1 
ATOM 1571 C C   . ALA A 1 208 ? 58.887 31.510 30.990 1.00 0.45 ? 208 ALA A C   1 
ATOM 1572 O O   . ALA A 1 208 ? 57.814 31.055 31.376 1.00 0.45 ? 208 ALA A O   1 
ATOM 1573 C CB  . ALA A 1 208 ? 60.323 30.297 29.364 1.00 0.45 ? 208 ALA A CB  1 
ATOM 1574 N N   . ARG A 1 209 ? 59.008 32.806 30.633 1.00 0.38 ? 209 ARG A N   1 
ATOM 1575 C CA  . ARG A 1 209 ? 57.881 33.716 30.503 1.00 0.38 ? 209 ARG A CA  1 
ATOM 1576 C C   . ARG A 1 209 ? 57.125 33.513 29.186 1.00 0.38 ? 209 ARG A C   1 
ATOM 1577 O O   . ARG A 1 209 ? 57.048 34.393 28.325 1.00 0.38 ? 209 ARG A O   1 
ATOM 1578 C CB  . ARG A 1 209 ? 58.352 35.185 30.663 1.00 0.38 ? 209 ARG A CB  1 
ATOM 1579 C CG  . ARG A 1 209 ? 58.643 35.553 32.132 1.00 0.38 ? 209 ARG A CG  1 
ATOM 1580 C CD  . ARG A 1 209 ? 59.101 36.999 32.352 1.00 0.38 ? 209 ARG A CD  1 
ATOM 1581 N NE  . ARG A 1 209 ? 59.050 37.256 33.829 1.00 0.38 ? 209 ARG A NE  1 
ATOM 1582 C CZ  . ARG A 1 209 ? 60.073 37.355 34.685 1.00 0.38 ? 209 ARG A CZ  1 
ATOM 1583 N NH1 . ARG A 1 209 ? 59.823 37.572 35.974 1.00 0.38 ? 209 ARG A NH1 1 
ATOM 1584 N NH2 . ARG A 1 209 ? 61.331 37.257 34.271 1.00 0.38 ? 209 ARG A NH2 1 
ATOM 1585 N N   . MET A 1 210 ? 56.520 32.323 29.020 1.00 0.33 ? 210 MET A N   1 
ATOM 1586 C CA  . MET A 1 210 ? 55.854 31.858 27.821 1.00 0.33 ? 210 MET A CA  1 
ATOM 1587 C C   . MET A 1 210 ? 54.431 31.455 28.160 1.00 0.33 ? 210 MET A C   1 
ATOM 1588 O O   . MET A 1 210 ? 54.142 31.032 29.276 1.00 0.33 ? 210 MET A O   1 
ATOM 1589 C CB  . MET A 1 210 ? 56.633 30.647 27.241 1.00 0.33 ? 210 MET A CB  1 
ATOM 1590 C CG  . MET A 1 210 ? 55.996 29.917 26.039 1.00 0.33 ? 210 MET A CG  1 
ATOM 1591 S SD  . MET A 1 210 ? 55.644 30.984 24.607 1.00 0.33 ? 210 MET A SD  1 
ATOM 1592 C CE  . MET A 1 210 ? 54.918 29.655 23.610 1.00 0.33 ? 210 MET A CE  1 
ATOM 1593 N N   . ALA A 1 211 ? 53.495 31.617 27.197 1.00 0.43 ? 211 ALA A N   1 
ATOM 1594 C CA  . ALA A 1 211 ? 52.125 31.158 27.299 1.00 0.43 ? 211 ALA A CA  1 
ATOM 1595 C C   . ALA A 1 211 ? 52.042 29.645 27.135 1.00 0.43 ? 211 ALA A C   1 
ATOM 1596 O O   . ALA A 1 211 ? 52.299 29.119 26.052 1.00 0.43 ? 211 ALA A O   1 
ATOM 1597 C CB  . ALA A 1 211 ? 51.263 31.828 26.205 1.00 0.43 ? 211 ALA A CB  1 
ATOM 1598 N N   . GLY A 1 212 ? 51.660 28.912 28.205 1.00 0.47 ? 212 GLY A N   1 
ATOM 1599 C CA  . GLY A 1 212 ? 51.698 27.452 28.235 1.00 0.47 ? 212 GLY A CA  1 
ATOM 1600 C C   . GLY A 1 212 ? 53.074 26.864 28.044 1.00 0.47 ? 212 GLY A C   1 
ATOM 1601 O O   . GLY A 1 212 ? 54.038 27.330 28.639 1.00 0.47 ? 212 GLY A O   1 
ATOM 1602 N N   . ASN A 1 213 ? 53.172 25.782 27.244 1.00 0.42 ? 213 ASN A N   1 
ATOM 1603 C CA  . ASN A 1 213 ? 54.417 25.084 26.951 1.00 0.42 ? 213 ASN A CA  1 
ATOM 1604 C C   . ASN A 1 213 ? 55.066 24.427 28.176 1.00 0.42 ? 213 ASN A C   1 
ATOM 1605 O O   . ASN A 1 213 ? 56.289 24.335 28.292 1.00 0.42 ? 213 ASN A O   1 
ATOM 1606 C CB  . ASN A 1 213 ? 55.379 26.025 26.165 1.00 0.42 ? 213 ASN A CB  1 
ATOM 1607 C CG  . ASN A 1 213 ? 56.445 25.268 25.383 1.00 0.42 ? 213 ASN A CG  1 
ATOM 1608 O OD1 . ASN A 1 213 ? 56.171 24.256 24.738 1.00 0.42 ? 213 ASN A OD1 1 
ATOM 1609 N ND2 . ASN A 1 213 ? 57.690 25.796 25.366 1.00 0.42 ? 213 ASN A ND2 1 
ATOM 1610 N N   . GLY A 1 214 ? 54.231 23.938 29.113 1.00 0.45 ? 214 GLY A N   1 
ATOM 1611 C CA  . GLY A 1 214 ? 54.662 23.200 30.285 1.00 0.45 ? 214 GLY A CA  1 
ATOM 1612 C C   . GLY A 1 214 ? 53.814 23.565 31.466 1.00 0.45 ? 214 GLY A C   1 
ATOM 1613 O O   . GLY A 1 214 ? 53.496 24.734 31.689 1.00 0.45 ? 214 GLY A O   1 
ATOM 1614 N N   . GLY A 1 215 ? 53.435 22.574 32.290 1.00 0.46 ? 215 GLY A N   1 
ATOM 1615 C CA  . GLY A 1 215 ? 52.574 22.777 33.456 1.00 0.46 ? 215 GLY A CA  1 
ATOM 1616 C C   . GLY A 1 215 ? 53.091 23.689 34.542 1.00 0.46 ? 215 GLY A C   1 
ATOM 1617 O O   . GLY A 1 215 ? 52.323 24.333 35.249 1.00 0.46 ? 215 GLY A O   1 
ATOM 1618 N N   . ASP A 1 216 ? 54.424 23.796 34.673 1.00 0.41 ? 216 ASP A N   1 
ATOM 1619 C CA  . ASP A 1 216 ? 55.093 24.690 35.598 1.00 0.41 ? 216 ASP A CA  1 
ATOM 1620 C C   . ASP A 1 216 ? 55.134 26.136 35.101 1.00 0.41 ? 216 ASP A C   1 
ATOM 1621 O O   . ASP A 1 216 ? 55.493 27.054 35.832 1.00 0.41 ? 216 ASP A O   1 
ATOM 1622 C CB  . ASP A 1 216 ? 56.529 24.180 35.881 1.00 0.41 ? 216 ASP A CB  1 
ATOM 1623 C CG  . ASP A 1 216 ? 56.496 22.903 36.705 1.00 0.41 ? 216 ASP A CG  1 
ATOM 1624 O OD1 . ASP A 1 216 ? 55.451 22.633 37.354 1.00 0.41 ? 216 ASP A OD1 1 
ATOM 1625 O OD2 . ASP A 1 216 ? 57.523 22.184 36.703 1.00 0.41 ? 216 ASP A OD2 1 
ATOM 1626 N N   . ALA A 1 217 ? 54.772 26.408 33.827 1.00 0.45 ? 217 ALA A N   1 
ATOM 1627 C CA  . ALA A 1 217 ? 54.620 27.767 33.344 1.00 0.45 ? 217 ALA A CA  1 
ATOM 1628 C C   . ALA A 1 217 ? 53.377 28.443 33.920 1.00 0.45 ? 217 ALA A C   1 
ATOM 1629 O O   . ALA A 1 217 ? 53.366 29.651 34.156 1.00 0.45 ? 217 ALA A O   1 
ATOM 1630 C CB  . ALA A 1 217 ? 54.625 27.799 31.805 1.00 0.45 ? 217 ALA A CB  1 
ATOM 1631 N N   . ALA A 1 218 ? 52.312 27.654 34.183 1.00 0.45 ? 218 ALA A N   1 
ATOM 1632 C CA  . ALA A 1 218 ? 51.149 28.069 34.936 1.00 0.45 ? 218 ALA A CA  1 
ATOM 1633 C C   . ALA A 1 218 ? 51.475 28.174 36.422 1.00 0.45 ? 218 ALA A C   1 
ATOM 1634 O O   . ALA A 1 218 ? 52.542 27.771 36.880 1.00 0.45 ? 218 ALA A O   1 
ATOM 1635 C CB  . ALA A 1 218 ? 49.989 27.073 34.715 1.00 0.45 ? 218 ALA A CB  1 
ATOM 1636 N N   . LEU A 1 219 ? 50.553 28.746 37.228 1.00 0.46 ? 219 LEU A N   1 
ATOM 1637 C CA  . LEU A 1 219 ? 50.789 29.032 38.635 1.00 0.46 ? 219 LEU A CA  1 
ATOM 1638 C C   . LEU A 1 219 ? 52.040 29.893 38.872 1.00 0.46 ? 219 LEU A C   1 
ATOM 1639 O O   . LEU A 1 219 ? 52.272 30.859 38.149 1.00 0.46 ? 219 LEU A O   1 
ATOM 1640 C CB  . LEU A 1 219 ? 50.788 27.733 39.492 1.00 0.46 ? 219 LEU A CB  1 
ATOM 1641 C CG  . LEU A 1 219 ? 49.584 26.800 39.248 1.00 0.46 ? 219 LEU A CG  1 
ATOM 1642 C CD1 . LEU A 1 219 ? 49.771 25.467 39.989 1.00 0.46 ? 219 LEU A CD1 1 
ATOM 1643 C CD2 . LEU A 1 219 ? 48.246 27.452 39.631 1.00 0.46 ? 219 LEU A CD2 1 
ATOM 1644 N N   . ALA A 1 220 ? 52.860 29.570 39.901 1.00 0.55 ? 220 ALA A N   1 
ATOM 1645 C CA  . ALA A 1 220 ? 54.272 29.910 40.005 1.00 0.55 ? 220 ALA A CA  1 
ATOM 1646 C C   . ALA A 1 220 ? 54.704 31.307 39.563 1.00 0.55 ? 220 ALA A C   1 
ATOM 1647 O O   . ALA A 1 220 ? 54.210 32.306 40.082 1.00 0.55 ? 220 ALA A O   1 
ATOM 1648 C CB  . ALA A 1 220 ? 55.070 28.764 39.359 1.00 0.55 ? 220 ALA A CB  1 
ATOM 1649 N N   . LEU A 1 221 ? 55.654 31.406 38.610 1.00 0.51 ? 221 LEU A N   1 
ATOM 1650 C CA  . LEU A 1 221 ? 56.171 32.665 38.090 1.00 0.51 ? 221 LEU A CA  1 
ATOM 1651 C C   . LEU A 1 221 ? 55.101 33.565 37.495 1.00 0.51 ? 221 LEU A C   1 
ATOM 1652 O O   . LEU A 1 221 ? 55.100 34.765 37.739 1.00 0.51 ? 221 LEU A O   1 
ATOM 1653 C CB  . LEU A 1 221 ? 57.280 32.378 37.048 1.00 0.51 ? 221 LEU A CB  1 
ATOM 1654 C CG  . LEU A 1 221 ? 58.121 33.548 36.507 1.00 0.51 ? 221 LEU A CG  1 
ATOM 1655 C CD1 . LEU A 1 221 ? 59.518 33.043 36.103 1.00 0.51 ? 221 LEU A CD1 1 
ATOM 1656 C CD2 . LEU A 1 221 ? 57.477 34.229 35.292 1.00 0.51 ? 221 LEU A CD2 1 
ATOM 1657 N N   . LEU A 1 222 ? 54.127 33.013 36.738 1.00 0.53 ? 222 LEU A N   1 
ATOM 1658 C CA  . LEU A 1 222 ? 53.032 33.768 36.155 1.00 0.53 ? 222 LEU A CA  1 
ATOM 1659 C C   . LEU A 1 222 ? 52.175 34.486 37.189 1.00 0.53 ? 222 LEU A C   1 
ATOM 1660 O O   . LEU A 1 222 ? 51.874 35.677 37.063 1.00 0.53 ? 222 LEU A O   1 
ATOM 1661 C CB  . LEU A 1 222 ? 52.146 32.767 35.367 1.00 0.53 ? 222 LEU A CB  1 
ATOM 1662 C CG  . LEU A 1 222 ? 50.735 33.241 34.964 1.00 0.53 ? 222 LEU A CG  1 
ATOM 1663 C CD1 . LEU A 1 222 ? 50.789 34.378 33.944 1.00 0.53 ? 222 LEU A CD1 1 
ATOM 1664 C CD2 . LEU A 1 222 ? 49.921 32.062 34.417 1.00 0.53 ? 222 LEU A CD2 1 
ATOM 1665 N N   . LEU A 1 223 ? 51.777 33.779 38.266 1.00 0.57 ? 223 LEU A N   1 
ATOM 1666 C CA  . LEU A 1 223 ? 51.052 34.384 39.368 1.00 0.57 ? 223 LEU A CA  1 
ATOM 1667 C C   . LEU A 1 223 ? 51.899 35.359 40.156 1.00 0.57 ? 223 LEU A C   1 
ATOM 1668 O O   . LEU A 1 223 ? 51.447 36.457 40.468 1.00 0.57 ? 223 LEU A O   1 
ATOM 1669 C CB  . LEU A 1 223 ? 50.442 33.339 40.326 1.00 0.57 ? 223 LEU A CB  1 
ATOM 1670 C CG  . LEU A 1 223 ? 49.343 32.456 39.699 1.00 0.57 ? 223 LEU A CG  1 
ATOM 1671 C CD1 . LEU A 1 223 ? 48.826 31.450 40.740 1.00 0.57 ? 223 LEU A CD1 1 
ATOM 1672 C CD2 . LEU A 1 223 ? 48.165 33.268 39.133 1.00 0.57 ? 223 LEU A CD2 1 
ATOM 1673 N N   . LEU A 1 224 ? 53.166 35.007 40.457 1.00 0.49 ? 224 LEU A N   1 
ATOM 1674 C CA  . LEU A 1 224 ? 54.078 35.894 41.153 1.00 0.49 ? 224 LEU A CA  1 
ATOM 1675 C C   . LEU A 1 224 ? 54.365 37.189 40.399 1.00 0.49 ? 224 LEU A C   1 
ATOM 1676 O O   . LEU A 1 224 ? 54.244 38.258 40.988 1.00 0.49 ? 224 LEU A O   1 
ATOM 1677 C CB  . LEU A 1 224 ? 55.401 35.169 41.508 1.00 0.49 ? 224 LEU A CB  1 
ATOM 1678 C CG  . LEU A 1 224 ? 55.280 34.109 42.627 1.00 0.49 ? 224 LEU A CG  1 
ATOM 1679 C CD1 . LEU A 1 224 ? 56.573 33.285 42.728 1.00 0.49 ? 224 LEU A CD1 1 
ATOM 1680 C CD2 . LEU A 1 224 ? 54.957 34.737 43.992 1.00 0.49 ? 224 LEU A CD2 1 
ATOM 1681 N N   . ASP A 1 225 ? 54.653 37.155 39.076 1.00 0.44 ? 225 ASP A N   1 
ATOM 1682 C CA  . ASP A 1 225 ? 54.817 38.354 38.269 1.00 0.44 ? 225 ASP A CA  1 
ATOM 1683 C C   . ASP A 1 225 ? 53.550 39.217 38.256 1.00 0.44 ? 225 ASP A C   1 
ATOM 1684 O O   . ASP A 1 225 ? 53.591 40.413 38.540 1.00 0.44 ? 225 ASP A O   1 
ATOM 1685 C CB  . ASP A 1 225 ? 55.139 37.997 36.780 1.00 0.44 ? 225 ASP A CB  1 
ATOM 1686 C CG  . ASP A 1 225 ? 56.597 37.765 36.416 1.00 0.44 ? 225 ASP A CG  1 
ATOM 1687 O OD1 . ASP A 1 225 ? 57.522 37.847 37.259 1.00 0.44 ? 225 ASP A OD1 1 
ATOM 1688 O OD2 . ASP A 1 225 ? 56.837 37.544 35.197 1.00 0.44 ? 225 ASP A OD2 1 
ATOM 1689 N N   . ARG A 1 226 ? 52.365 38.638 37.960 1.00 0.49 ? 226 ARG A N   1 
ATOM 1690 C CA  . ARG A 1 226 ? 51.136 39.409 37.858 1.00 0.49 ? 226 ARG A CA  1 
ATOM 1691 C C   . ARG A 1 226 ? 50.654 40.006 39.163 1.00 0.49 ? 226 ARG A C   1 
ATOM 1692 O O   . ARG A 1 226 ? 50.301 41.186 39.233 1.00 0.49 ? 226 ARG A O   1 
ATOM 1693 C CB  . ARG A 1 226 ? 49.995 38.558 37.241 1.00 0.49 ? 226 ARG A CB  1 
ATOM 1694 C CG  . ARG A 1 226 ? 50.224 38.222 35.753 1.00 0.49 ? 226 ARG A CG  1 
ATOM 1695 C CD  . ARG A 1 226 ? 49.458 39.065 34.714 1.00 0.49 ? 226 ARG A CD  1 
ATOM 1696 N NE  . ARG A 1 226 ? 49.563 40.541 34.971 1.00 0.49 ? 226 ARG A NE  1 
ATOM 1697 C CZ  . ARG A 1 226 ? 50.668 41.286 34.891 1.00 0.49 ? 226 ARG A CZ  1 
ATOM 1698 N NH1 . ARG A 1 226 ? 50.606 42.549 35.305 1.00 0.49 ? 226 ARG A NH1 1 
ATOM 1699 N NH2 . ARG A 1 226 ? 51.840 40.842 34.465 1.00 0.49 ? 226 ARG A NH2 1 
ATOM 1700 N N   . LEU A 1 227 ? 50.644 39.207 40.242 1.00 0.53 ? 227 LEU A N   1 
ATOM 1701 C CA  . LEU A 1 227 ? 50.234 39.657 41.548 1.00 0.53 ? 227 LEU A CA  1 
ATOM 1702 C C   . LEU A 1 227 ? 51.235 40.595 42.200 1.00 0.53 ? 227 LEU A C   1 
ATOM 1703 O O   . LEU A 1 227 ? 50.831 41.608 42.767 1.00 0.53 ? 227 LEU A O   1 
ATOM 1704 C CB  . LEU A 1 227 ? 49.874 38.457 42.453 1.00 0.53 ? 227 LEU A CB  1 
ATOM 1705 C CG  . LEU A 1 227 ? 48.719 37.579 41.906 1.00 0.53 ? 227 LEU A CG  1 
ATOM 1706 C CD1 . LEU A 1 227 ? 48.512 36.349 42.802 1.00 0.53 ? 227 LEU A CD1 1 
ATOM 1707 C CD2 . LEU A 1 227 ? 47.395 38.350 41.735 1.00 0.53 ? 227 LEU A CD2 1 
ATOM 1708 N N   . ASN A 1 228 ? 52.565 40.337 42.096 1.00 0.39 ? 228 ASN A N   1 
ATOM 1709 C CA  . ASN A 1 228 ? 53.590 41.250 42.594 1.00 0.39 ? 228 ASN A CA  1 
ATOM 1710 C C   . ASN A 1 228 ? 53.616 42.575 41.830 1.00 0.39 ? 228 ASN A C   1 
ATOM 1711 O O   . ASN A 1 228 ? 53.843 43.626 42.418 1.00 0.39 ? 228 ASN A O   1 
ATOM 1712 C CB  . ASN A 1 228 ? 55.024 40.645 42.724 1.00 0.39 ? 228 ASN A CB  1 
ATOM 1713 C CG  . ASN A 1 228 ? 55.161 39.512 43.749 1.00 0.39 ? 228 ASN A CG  1 
ATOM 1714 O OD1 . ASN A 1 228 ? 56.215 38.873 43.860 1.00 0.39 ? 228 ASN A OD1 1 
ATOM 1715 N ND2 . ASN A 1 228 ? 54.140 39.276 44.596 1.00 0.39 ? 228 ASN A ND2 1 
ATOM 1716 N N   . GLN A 1 229 ? 53.341 42.593 40.505 1.00 0.45 ? 229 GLN A N   1 
ATOM 1717 C CA  . GLN A 1 229 ? 53.164 43.843 39.772 1.00 0.45 ? 229 GLN A CA  1 
ATOM 1718 C C   . GLN A 1 229 ? 51.984 44.696 40.218 1.00 0.45 ? 229 GLN A C   1 
ATOM 1719 O O   . GLN A 1 229 ? 52.117 45.908 40.375 1.00 0.45 ? 229 GLN A O   1 
ATOM 1720 C CB  . GLN A 1 229 ? 53.055 43.607 38.249 1.00 0.45 ? 229 GLN A CB  1 
ATOM 1721 C CG  . GLN A 1 229 ? 54.439 43.387 37.610 1.00 0.45 ? 229 GLN A CG  1 
ATOM 1722 C CD  . GLN A 1 229 ? 54.375 43.249 36.091 1.00 0.45 ? 229 GLN A CD  1 
ATOM 1723 O OE1 . GLN A 1 229 ? 53.324 43.084 35.461 1.00 0.45 ? 229 GLN A OE1 1 
ATOM 1724 N NE2 . GLN A 1 229 ? 55.567 43.342 35.463 1.00 0.45 ? 229 GLN A NE2 1 
ATOM 1725 N N   . LEU A 1 230 ? 50.804 44.089 40.460 1.00 0.48 ? 230 LEU A N   1 
ATOM 1726 C CA  . LEU A 1 230 ? 49.648 44.758 41.040 1.00 0.48 ? 230 LEU A CA  1 
ATOM 1727 C C   . LEU A 1 230 ? 49.903 45.272 42.459 1.00 0.48 ? 230 LEU A C   1 
ATOM 1728 O O   . LEU A 1 230 ? 49.530 46.388 42.819 1.00 0.48 ? 230 LEU A O   1 
ATOM 1729 C CB  . LEU A 1 230 ? 48.430 43.806 41.016 1.00 0.48 ? 230 LEU A CB  1 
ATOM 1730 C CG  . LEU A 1 230 ? 47.848 43.576 39.602 1.00 0.48 ? 230 LEU A CG  1 
ATOM 1731 C CD1 . LEU A 1 230 ? 46.966 42.318 39.553 1.00 0.48 ? 230 LEU A CD1 1 
ATOM 1732 C CD2 . LEU A 1 230 ? 47.050 44.803 39.121 1.00 0.48 ? 230 LEU A CD2 1 
ATOM 1733 N N   . GLU A 1 231 ? 50.609 44.465 43.274 1.00 0.49 ? 231 GLU A N   1 
ATOM 1734 C CA  . GLU A 1 231 ? 51.062 44.759 44.623 1.00 0.49 ? 231 GLU A CA  1 
ATOM 1735 C C   . GLU A 1 231 ? 52.149 45.843 44.714 1.00 0.49 ? 231 GLU A C   1 
ATOM 1736 O O   . GLU A 1 231 ? 52.294 46.480 45.756 1.00 0.49 ? 231 GLU A O   1 
ATOM 1737 C CB  . GLU A 1 231 ? 51.571 43.415 45.207 1.00 0.49 ? 231 GLU A CB  1 
ATOM 1738 C CG  . GLU A 1 231 ? 52.415 43.437 46.506 1.00 0.49 ? 231 GLU A CG  1 
ATOM 1739 C CD  . GLU A 1 231 ? 52.939 42.076 46.926 1.00 0.49 ? 231 GLU A CD  1 
ATOM 1740 O OE1 . GLU A 1 231 ? 52.593 41.047 46.285 1.00 0.49 ? 231 GLU A OE1 1 
ATOM 1741 O OE2 . GLU A 1 231 ? 53.699 42.001 47.933 1.00 0.49 ? 231 GLU A OE2 1 
ATOM 1742 N N   . SER A 1 232 ? 52.918 46.103 43.624 1.00 0.47 ? 232 SER A N   1 
ATOM 1743 C CA  . SER A 1 232 ? 54.103 46.975 43.604 1.00 0.47 ? 232 SER A CA  1 
ATOM 1744 C C   . SER A 1 232 ? 53.832 48.391 44.083 1.00 0.47 ? 232 SER A C   1 
ATOM 1745 O O   . SER A 1 232 ? 54.536 48.928 44.935 1.00 0.47 ? 232 SER A O   1 
ATOM 1746 C CB  . SER A 1 232 ? 54.747 47.012 42.174 1.00 0.47 ? 232 SER A CB  1 
ATOM 1747 O OG  . SER A 1 232 ? 55.830 47.935 42.037 1.00 0.47 ? 232 SER A OG  1 
ATOM 1748 N N   . LYS A 1 233 ? 52.739 49.011 43.599 1.00 0.45 ? 233 LYS A N   1 
ATOM 1749 C CA  . LYS A 1 233 ? 52.261 50.249 44.178 1.00 0.45 ? 233 LYS A CA  1 
ATOM 1750 C C   . LYS A 1 233 ? 51.128 49.995 45.158 1.00 0.45 ? 233 LYS A C   1 
ATOM 1751 O O   . LYS A 1 233 ? 51.229 50.332 46.338 1.00 0.45 ? 233 LYS A O   1 
ATOM 1752 C CB  . LYS A 1 233 ? 51.843 51.248 43.074 1.00 0.45 ? 233 LYS A CB  1 
ATOM 1753 C CG  . LYS A 1 233 ? 53.047 51.733 42.246 1.00 0.45 ? 233 LYS A CG  1 
ATOM 1754 C CD  . LYS A 1 233 ? 52.709 52.834 41.223 1.00 0.45 ? 233 LYS A CD  1 
ATOM 1755 C CE  . LYS A 1 233 ? 52.322 54.163 41.881 1.00 0.45 ? 233 LYS A CE  1 
ATOM 1756 N NZ  . LYS A 1 233 ? 52.240 55.238 40.867 1.00 0.45 ? 233 LYS A NZ  1 
ATOM 1757 N N   . MET A 1 234 ? 50.007 49.395 44.693 1.00 0.43 ? 234 MET A N   1 
ATOM 1758 C CA  . MET A 1 234 ? 48.846 49.042 45.496 1.00 0.43 ? 234 MET A CA  1 
ATOM 1759 C C   . MET A 1 234 ? 48.172 50.228 46.188 1.00 0.43 ? 234 MET A C   1 
ATOM 1760 O O   . MET A 1 234 ? 47.539 50.132 47.246 1.00 0.43 ? 234 MET A O   1 
ATOM 1761 C CB  . MET A 1 234 ? 49.173 47.849 46.429 1.00 0.43 ? 234 MET A CB  1 
ATOM 1762 C CG  . MET A 1 234 ? 47.963 47.066 46.975 1.00 0.43 ? 234 MET A CG  1 
ATOM 1763 S SD  . MET A 1 234 ? 48.383 45.381 47.512 1.00 0.43 ? 234 MET A SD  1 
ATOM 1764 C CE  . MET A 1 234 ? 46.740 44.971 48.163 1.00 0.43 ? 234 MET A CE  1 
ATOM 1765 N N   . SER A 1 235 ? 48.270 51.408 45.548 1.00 0.44 ? 235 SER A N   1 
ATOM 1766 C CA  . SER A 1 235 ? 47.726 52.678 45.975 1.00 0.44 ? 235 SER A CA  1 
ATOM 1767 C C   . SER A 1 235 ? 46.218 52.761 45.774 1.00 0.44 ? 235 SER A C   1 
ATOM 1768 O O   . SER A 1 235 ? 45.584 51.882 45.195 1.00 0.44 ? 235 SER A O   1 
ATOM 1769 C CB  . SER A 1 235 ? 48.509 53.871 45.345 1.00 0.44 ? 235 SER A CB  1 
ATOM 1770 O OG  . SER A 1 235 ? 49.002 53.626 44.022 1.00 0.44 ? 235 SER A OG  1 
ATOM 1771 N N   . GLY A 1 236 ? 45.551 53.784 46.351 1.00 0.48 ? 236 GLY A N   1 
ATOM 1772 C CA  . GLY A 1 236 ? 44.114 53.926 46.187 1.00 0.48 ? 236 GLY A CA  1 
ATOM 1773 C C   . GLY A 1 236 ? 43.675 55.312 46.557 1.00 0.48 ? 236 GLY A C   1 
ATOM 1774 O O   . GLY A 1 236 ? 44.470 56.106 47.049 1.00 0.48 ? 236 GLY A O   1 
ATOM 1775 N N   . LYS A 1 237 ? 42.372 55.613 46.368 1.00 0.28 ? 237 LYS A N   1 
ATOM 1776 C CA  . LYS A 1 237 ? 41.787 56.951 46.418 1.00 0.28 ? 237 LYS A CA  1 
ATOM 1777 C C   . LYS A 1 237 ? 41.841 57.657 47.770 1.00 0.28 ? 237 LYS A C   1 
ATOM 1778 O O   . LYS A 1 237 ? 41.757 58.880 47.851 1.00 0.28 ? 237 LYS A O   1 
ATOM 1779 C CB  . LYS A 1 237 ? 40.309 56.866 45.925 1.00 0.28 ? 237 LYS A CB  1 
ATOM 1780 C CG  . LYS A 1 237 ? 39.538 58.196 45.748 1.00 0.28 ? 237 LYS A CG  1 
ATOM 1781 C CD  . LYS A 1 237 ? 40.174 59.166 44.733 1.00 0.28 ? 237 LYS A CD  1 
ATOM 1782 C CE  . LYS A 1 237 ? 39.408 60.482 44.528 1.00 0.28 ? 237 LYS A CE  1 
ATOM 1783 N NZ  . LYS A 1 237 ? 38.158 60.245 43.772 1.00 0.28 ? 237 LYS A NZ  1 
ATOM 1784 N N   . GLY A 1 238 ? 42.015 56.904 48.875 1.00 0.40 ? 238 GLY A N   1 
ATOM 1785 C CA  . GLY A 1 238 ? 42.195 57.467 50.211 1.00 0.40 ? 238 GLY A CA  1 
ATOM 1786 C C   . GLY A 1 238 ? 43.580 57.997 50.508 1.00 0.40 ? 238 GLY A C   1 
ATOM 1787 O O   . GLY A 1 238 ? 43.824 58.509 51.594 1.00 0.40 ? 238 GLY A O   1 
ATOM 1788 N N   . GLN A 1 239 ? 44.539 57.874 49.573 1.00 0.39 ? 239 GLN A N   1 
ATOM 1789 C CA  . GLN A 1 239 ? 45.897 58.342 49.766 1.00 0.39 ? 239 GLN A CA  1 
ATOM 1790 C C   . GLN A 1 239 ? 46.178 59.514 48.843 1.00 0.39 ? 239 GLN A C   1 
ATOM 1791 O O   . GLN A 1 239 ? 45.874 59.460 47.656 1.00 0.39 ? 239 GLN A O   1 
ATOM 1792 C CB  . GLN A 1 239 ? 46.917 57.228 49.408 1.00 0.39 ? 239 GLN A CB  1 
ATOM 1793 C CG  . GLN A 1 239 ? 46.805 55.979 50.315 1.00 0.39 ? 239 GLN A CG  1 
ATOM 1794 C CD  . GLN A 1 239 ? 47.525 54.765 49.735 1.00 0.39 ? 239 GLN A CD  1 
ATOM 1795 O OE1 . GLN A 1 239 ? 46.912 53.733 49.437 1.00 0.39 ? 239 GLN A OE1 1 
ATOM 1796 N NE2 . GLN A 1 239 ? 48.862 54.879 49.592 1.00 0.39 ? 239 GLN A NE2 1 
ATOM 1797 N N   . GLN A 1 240 ? 46.788 60.606 49.361 1.00 0.33 ? 240 GLN A N   1 
ATOM 1798 C CA  . GLN A 1 240 ? 47.178 61.741 48.534 1.00 0.33 ? 240 GLN A CA  1 
ATOM 1799 C C   . GLN A 1 240 ? 48.342 61.458 47.587 1.00 0.33 ? 240 GLN A C   1 
ATOM 1800 O O   . GLN A 1 240 ? 48.284 61.748 46.396 1.00 0.33 ? 240 GLN A O   1 
ATOM 1801 C CB  . GLN A 1 240 ? 47.551 62.946 49.436 1.00 0.33 ? 240 GLN A CB  1 
ATOM 1802 C CG  . GLN A 1 240 ? 47.941 64.230 48.660 1.00 0.33 ? 240 GLN A CG  1 
ATOM 1803 C CD  . GLN A 1 240 ? 48.142 65.422 49.595 1.00 0.33 ? 240 GLN A CD  1 
ATOM 1804 O OE1 . GLN A 1 240 ? 48.086 65.325 50.818 1.00 0.33 ? 240 GLN A OE1 1 
ATOM 1805 N NE2 . GLN A 1 240 ? 48.393 66.607 48.988 1.00 0.33 ? 240 GLN A NE2 1 
ATOM 1806 N N   . GLN A 1 241 ? 49.435 60.860 48.099 1.00 0.41 ? 241 GLN A N   1 
ATOM 1807 C CA  . GLN A 1 241 ? 50.583 60.513 47.292 1.00 0.41 ? 241 GLN A CA  1 
ATOM 1808 C C   . GLN A 1 241 ? 51.426 59.517 48.070 1.00 0.41 ? 241 GLN A C   1 
ATOM 1809 O O   . GLN A 1 241 ? 51.800 59.762 49.211 1.00 0.41 ? 241 GLN A O   1 
ATOM 1810 C CB  . GLN A 1 241 ? 51.421 61.760 46.892 1.00 0.41 ? 241 GLN A CB  1 
ATOM 1811 C CG  . GLN A 1 241 ? 52.701 61.440 46.082 1.00 0.41 ? 241 GLN A CG  1 
ATOM 1812 C CD  . GLN A 1 241 ? 53.221 62.610 45.240 1.00 0.41 ? 241 GLN A CD  1 
ATOM 1813 O OE1 . GLN A 1 241 ? 53.727 62.384 44.141 1.00 0.41 ? 241 GLN A OE1 1 
ATOM 1814 N NE2 . GLN A 1 241 ? 53.132 63.855 45.751 1.00 0.41 ? 241 GLN A NE2 1 
ATOM 1815 N N   . GLN A 1 242 ? 51.694 58.320 47.497 1.00 0.44 ? 242 GLN A N   1 
ATOM 1816 C CA  . GLN A 1 242 ? 52.456 57.278 48.174 1.00 0.44 ? 242 GLN A CA  1 
ATOM 1817 C C   . GLN A 1 242 ? 53.967 57.497 48.174 1.00 0.44 ? 242 GLN A C   1 
ATOM 1818 O O   . GLN A 1 242 ? 54.649 57.267 49.167 1.00 0.44 ? 242 GLN A O   1 
ATOM 1819 C CB  . GLN A 1 242 ? 52.077 55.888 47.602 1.00 0.44 ? 242 GLN A CB  1 
ATOM 1820 C CG  . GLN A 1 242 ? 52.641 54.684 48.403 1.00 0.44 ? 242 GLN A CG  1 
ATOM 1821 C CD  . GLN A 1 242 ? 51.869 53.392 48.105 1.00 0.44 ? 242 GLN A CD  1 
ATOM 1822 O OE1 . GLN A 1 242 ? 50.638 53.410 48.016 1.00 0.44 ? 242 GLN A OE1 1 
ATOM 1823 N NE2 . GLN A 1 242 ? 52.576 52.251 47.985 1.00 0.44 ? 242 GLN A NE2 1 
ATOM 1824 N N   . GLY A 1 243 ? 54.542 57.960 47.042 1.00 0.52 ? 243 GLY A N   1 
ATOM 1825 C CA  . GLY A 1 243 ? 55.922 58.451 47.013 1.00 0.52 ? 243 GLY A CA  1 
ATOM 1826 C C   . GLY A 1 243 ? 57.039 57.438 47.045 1.00 0.52 ? 243 GLY A C   1 
ATOM 1827 O O   . GLY A 1 243 ? 58.199 57.807 47.229 1.00 0.52 ? 243 GLY A O   1 
ATOM 1828 N N   . GLN A 1 244 ? 56.734 56.140 46.896 1.00 0.49 ? 244 GLN A N   1 
ATOM 1829 C CA  . GLN A 1 244 ? 57.717 55.081 47.060 1.00 0.49 ? 244 GLN A CA  1 
ATOM 1830 C C   . GLN A 1 244 ? 58.384 54.613 45.774 1.00 0.49 ? 244 GLN A C   1 
ATOM 1831 O O   . GLN A 1 244 ? 59.371 53.887 45.839 1.00 0.49 ? 244 GLN A O   1 
ATOM 1832 C CB  . GLN A 1 244 ? 57.037 53.866 47.729 1.00 0.49 ? 244 GLN A CB  1 
ATOM 1833 C CG  . GLN A 1 244 ? 56.665 54.150 49.204 1.00 0.49 ? 244 GLN A CG  1 
ATOM 1834 C CD  . GLN A 1 244 ? 55.920 52.971 49.831 1.00 0.49 ? 244 GLN A CD  1 
ATOM 1835 O OE1 . GLN A 1 244 ? 55.119 52.303 49.176 1.00 0.49 ? 244 GLN A OE1 1 
ATOM 1836 N NE2 . GLN A 1 244 ? 56.141 52.731 51.143 1.00 0.49 ? 244 GLN A NE2 1 
ATOM 1837 N N   . THR A 1 245 ? 57.865 55.031 44.597 1.00 0.44 ? 245 THR A N   1 
ATOM 1838 C CA  . THR A 1 245 ? 58.492 54.891 43.273 1.00 0.44 ? 245 THR A CA  1 
ATOM 1839 C C   . THR A 1 245 ? 58.995 53.495 42.901 1.00 0.44 ? 245 THR A C   1 
ATOM 1840 O O   . THR A 1 245 ? 60.054 53.319 42.305 1.00 0.44 ? 245 THR A O   1 
ATOM 1841 C CB  . THR A 1 245 ? 59.516 55.988 42.944 1.00 0.44 ? 245 THR A CB  1 
ATOM 1842 O OG1 . THR A 1 245 ? 60.602 56.046 43.853 1.00 0.44 ? 245 THR A OG1 1 
ATOM 1843 C CG2 . THR A 1 245 ? 58.852 57.370 43.053 1.00 0.44 ? 245 THR A CG2 1 
ATOM 1844 N N   . VAL A 1 246 ? 58.194 52.454 43.217 1.00 0.37 ? 246 VAL A N   1 
ATOM 1845 C CA  . VAL A 1 246 ? 58.546 51.053 43.052 1.00 0.37 ? 246 VAL A CA  1 
ATOM 1846 C C   . VAL A 1 246 ? 58.560 50.588 41.590 1.00 0.37 ? 246 VAL A C   1 
ATOM 1847 O O   . VAL A 1 246 ? 57.807 51.067 40.735 1.00 0.37 ? 246 VAL A O   1 
ATOM 1848 C CB  . VAL A 1 246 ? 57.677 50.151 43.934 1.00 0.37 ? 246 VAL A CB  1 
ATOM 1849 C CG1 . VAL A 1 246 ? 58.281 48.737 44.076 1.00 0.37 ? 246 VAL A CG1 1 
ATOM 1850 C CG2 . VAL A 1 246 ? 57.512 50.771 45.344 1.00 0.37 ? 246 VAL A CG2 1 
ATOM 1851 N N   . THR A 1 247 ? 59.468 49.648 41.257 1.00 0.45 ? 247 THR A N   1 
ATOM 1852 C CA  . THR A 1 247 ? 59.699 49.118 39.925 1.00 0.45 ? 247 THR A CA  1 
ATOM 1853 C C   . THR A 1 247 ? 58.607 48.183 39.418 1.00 0.45 ? 247 THR A C   1 
ATOM 1854 O O   . THR A 1 247 ? 57.821 47.595 40.160 1.00 0.45 ? 247 THR A O   1 
ATOM 1855 C CB  . THR A 1 247 ? 61.059 48.418 39.796 1.00 0.45 ? 247 THR A CB  1 
ATOM 1856 O OG1 . THR A 1 247 ? 61.211 47.351 40.723 1.00 0.45 ? 247 THR A OG1 1 
ATOM 1857 C CG2 . THR A 1 247 ? 62.198 49.406 40.095 1.00 0.45 ? 247 THR A CG2 1 
ATOM 1858 N N   . LYS A 1 248 ? 58.518 48.016 38.080 1.00 0.46 ? 248 LYS A N   1 
ATOM 1859 C CA  . LYS A 1 248 ? 57.631 47.038 37.473 1.00 0.46 ? 248 LYS A CA  1 
ATOM 1860 C C   . LYS A 1 248 ? 58.282 45.669 37.294 1.00 0.46 ? 248 LYS A C   1 
ATOM 1861 O O   . LYS A 1 248 ? 57.600 44.690 36.993 1.00 0.46 ? 248 LYS A O   1 
ATOM 1862 C CB  . LYS A 1 248 ? 57.211 47.507 36.055 1.00 0.46 ? 248 LYS A CB  1 
ATOM 1863 C CG  . LYS A 1 248 ? 56.437 48.838 36.036 1.00 0.46 ? 248 LYS A CG  1 
ATOM 1864 C CD  . LYS A 1 248 ? 55.991 49.221 34.611 1.00 0.46 ? 248 LYS A CD  1 
ATOM 1865 C CE  . LYS A 1 248 ? 55.184 50.523 34.512 1.00 0.46 ? 248 LYS A CE  1 
ATOM 1866 N NZ  . LYS A 1 248 ? 56.061 51.694 34.738 1.00 0.46 ? 248 LYS A NZ  1 
ATOM 1867 N N   . LYS A 1 249 ? 59.621 45.567 37.440 1.00 0.40 ? 249 LYS A N   1 
ATOM 1868 C CA  . LYS A 1 249 ? 60.375 44.361 37.155 1.00 0.40 ? 249 LYS A CA  1 
ATOM 1869 C C   . LYS A 1 249 ? 61.615 44.327 38.028 1.00 0.40 ? 249 LYS A C   1 
ATOM 1870 O O   . LYS A 1 249 ? 62.002 45.348 38.603 1.00 0.40 ? 249 LYS A O   1 
ATOM 1871 C CB  . LYS A 1 249 ? 60.882 44.308 35.686 1.00 0.40 ? 249 LYS A CB  1 
ATOM 1872 C CG  . LYS A 1 249 ? 59.770 44.174 34.636 1.00 0.40 ? 249 LYS A CG  1 
ATOM 1873 C CD  . LYS A 1 249 ? 60.299 44.000 33.199 1.00 0.40 ? 249 LYS A CD  1 
ATOM 1874 C CE  . LYS A 1 249 ? 61.092 45.210 32.684 1.00 0.40 ? 249 LYS A CE  1 
ATOM 1875 N NZ  . LYS A 1 249 ? 61.506 45.016 31.274 1.00 0.40 ? 249 LYS A NZ  1 
ATOM 1876 N N   . SER A 1 250 ? 62.275 43.149 38.106 1.00 0.45 ? 250 SER A N   1 
ATOM 1877 C CA  . SER A 1 250 ? 63.396 42.898 38.994 1.00 0.45 ? 250 SER A CA  1 
ATOM 1878 C C   . SER A 1 250 ? 64.514 42.200 38.271 1.00 0.45 ? 250 SER A C   1 
ATOM 1879 O O   . SER A 1 250 ? 64.270 41.288 37.485 1.00 0.45 ? 250 SER A O   1 
ATOM 1880 C CB  . SER A 1 250 ? 63.038 41.940 40.141 1.00 0.45 ? 250 SER A CB  1 
ATOM 1881 O OG  . SER A 1 250 ? 61.913 42.447 40.849 1.00 0.45 ? 250 SER A OG  1 
ATOM 1882 N N   . ALA A 1 251 ? 65.775 42.617 38.512 1.00 0.35 ? 251 ALA A N   1 
ATOM 1883 C CA  . ALA A 1 251 ? 66.964 41.935 38.025 1.00 0.35 ? 251 ALA A CA  1 
ATOM 1884 C C   . ALA A 1 251 ? 67.278 40.643 38.786 1.00 0.35 ? 251 ALA A C   1 
ATOM 1885 O O   . ALA A 1 251 ? 67.648 39.625 38.209 1.00 0.35 ? 251 ALA A O   1 
ATOM 1886 C CB  . ALA A 1 251 ? 68.167 42.904 38.092 1.00 0.35 ? 251 ALA A CB  1 
ATOM 1887 N N   . ALA A 1 252 ? 67.139 40.669 40.128 1.00 0.47 ? 252 ALA A N   1 
ATOM 1888 C CA  . ALA A 1 252 ? 67.318 39.520 40.987 1.00 0.47 ? 252 ALA A CA  1 
ATOM 1889 C C   . ALA A 1 252 ? 66.230 38.457 40.853 1.00 0.47 ? 252 ALA A C   1 
ATOM 1890 O O   . ALA A 1 252 ? 65.055 38.741 40.621 1.00 0.47 ? 252 ALA A O   1 
ATOM 1891 C CB  . ALA A 1 252 ? 67.423 39.982 42.456 1.00 0.47 ? 252 ALA A CB  1 
ATOM 1892 N N   . GLU A 1 253 ? 66.590 37.175 41.066 1.00 0.52 ? 253 GLU A N   1 
ATOM 1893 C CA  . GLU A 1 253 ? 65.681 36.058 40.879 1.00 0.52 ? 253 GLU A CA  1 
ATOM 1894 C C   . GLU A 1 253 ? 64.693 35.839 42.019 1.00 0.52 ? 253 GLU A C   1 
ATOM 1895 O O   . GLU A 1 253 ? 63.833 34.962 41.961 1.00 0.52 ? 253 GLU A O   1 
ATOM 1896 C CB  . GLU A 1 253 ? 66.482 34.758 40.692 1.00 0.52 ? 253 GLU A CB  1 
ATOM 1897 C CG  . GLU A 1 253 ? 67.301 34.744 39.387 1.00 0.52 ? 253 GLU A CG  1 
ATOM 1898 C CD  . GLU A 1 253 ? 67.688 33.301 39.072 1.00 0.52 ? 253 GLU A CD  1 
ATOM 1899 O OE1 . GLU A 1 253 ? 68.416 32.689 39.887 1.00 0.52 ? 253 GLU A OE1 1 
ATOM 1900 O OE2 . GLU A 1 253 ? 67.152 32.779 38.055 1.00 0.52 ? 253 GLU A OE2 1 
ATOM 1901 N N   . ALA A 1 254 ? 64.779 36.635 43.094 1.00 0.56 ? 254 ALA A N   1 
ATOM 1902 C CA  . ALA A 1 254 ? 63.906 36.577 44.248 1.00 0.56 ? 254 ALA A CA  1 
ATOM 1903 C C   . ALA A 1 254 ? 62.423 36.812 43.937 1.00 0.56 ? 254 ALA A C   1 
ATOM 1904 O O   . ALA A 1 254 ? 61.556 36.174 44.536 1.00 0.56 ? 254 ALA A O   1 
ATOM 1905 C CB  . ALA A 1 254 ? 64.421 37.570 45.303 1.00 0.56 ? 254 ALA A CB  1 
ATOM 1906 N N   . SER A 1 255 ? 62.088 37.689 42.963 1.00 0.54 ? 255 SER A N   1 
ATOM 1907 C CA  . SER A 1 255 ? 60.706 37.983 42.589 1.00 0.54 ? 255 SER A CA  1 
ATOM 1908 C C   . SER A 1 255 ? 59.946 36.849 41.950 1.00 0.54 ? 255 SER A C   1 
ATOM 1909 O O   . SER A 1 255 ? 58.721 36.814 42.014 1.00 0.54 ? 255 SER A O   1 
ATOM 1910 C CB  . SER A 1 255 ? 60.563 39.182 41.637 1.00 0.54 ? 255 SER A CB  1 
ATOM 1911 O OG  . SER A 1 255 ? 60.992 40.343 42.323 1.00 0.54 ? 255 SER A OG  1 
ATOM 1912 N N   . LYS A 1 256 ? 60.641 35.856 41.367 1.00 0.52 ? 256 LYS A N   1 
ATOM 1913 C CA  . LYS A 1 256 ? 59.996 34.685 40.811 1.00 0.52 ? 256 LYS A CA  1 
ATOM 1914 C C   . LYS A 1 256 ? 59.998 33.529 41.807 1.00 0.52 ? 256 LYS A C   1 
ATOM 1915 O O   . LYS A 1 256 ? 59.655 32.406 41.447 1.00 0.52 ? 256 LYS A O   1 
ATOM 1916 C CB  . LYS A 1 256 ? 60.629 34.241 39.458 1.00 0.52 ? 256 LYS A CB  1 
ATOM 1917 C CG  . LYS A 1 256 ? 62.134 33.934 39.498 1.00 0.52 ? 256 LYS A CG  1 
ATOM 1918 C CD  . LYS A 1 256 ? 62.682 33.296 38.202 1.00 0.52 ? 256 LYS A CD  1 
ATOM 1919 C CE  . LYS A 1 256 ? 64.192 33.080 38.296 1.00 0.52 ? 256 LYS A CE  1 
ATOM 1920 N NZ  . LYS A 1 256 ? 64.795 32.447 37.102 1.00 0.52 ? 256 LYS A NZ  1 
ATOM 1921 N N   . LYS A 1 257 ? 60.360 33.764 43.093 1.00 0.49 ? 257 LYS A N   1 
ATOM 1922 C CA  . LYS A 1 257 ? 60.415 32.723 44.108 1.00 0.49 ? 257 LYS A CA  1 
ATOM 1923 C C   . LYS A 1 257 ? 59.503 33.050 45.296 1.00 0.49 ? 257 LYS A C   1 
ATOM 1924 O O   . LYS A 1 257 ? 59.187 34.228 45.500 1.00 0.49 ? 257 LYS A O   1 
ATOM 1925 C CB  . LYS A 1 257 ? 61.876 32.515 44.587 1.00 0.49 ? 257 LYS A CB  1 
ATOM 1926 C CG  . LYS A 1 257 ? 62.741 31.860 43.497 1.00 0.49 ? 257 LYS A CG  1 
ATOM 1927 C CD  . LYS A 1 257 ? 64.161 31.476 43.947 1.00 0.49 ? 257 LYS A CD  1 
ATOM 1928 C CE  . LYS A 1 257 ? 65.054 32.683 44.253 1.00 0.49 ? 257 LYS A CE  1 
ATOM 1929 N NZ  . LYS A 1 257 ? 66.431 32.255 44.589 1.00 0.49 ? 257 LYS A NZ  1 
ATOM 1930 N N   . PRO A 1 258 ? 59.011 32.082 46.096 1.00 0.54 ? 258 PRO A N   1 
ATOM 1931 C CA  . PRO A 1 258 ? 58.159 32.336 47.262 1.00 0.54 ? 258 PRO A CA  1 
ATOM 1932 C C   . PRO A 1 258 ? 58.766 33.241 48.326 1.00 0.54 ? 258 PRO A C   1 
ATOM 1933 O O   . PRO A 1 258 ? 59.986 33.340 48.413 1.00 0.54 ? 258 PRO A O   1 
ATOM 1934 C CB  . PRO A 1 258 ? 57.861 30.939 47.837 1.00 0.54 ? 258 PRO A CB  1 
ATOM 1935 C CG  . PRO A 1 258 ? 58.097 29.986 46.667 1.00 0.54 ? 258 PRO A CG  1 
ATOM 1936 C CD  . PRO A 1 258 ? 59.256 30.648 45.926 1.00 0.54 ? 258 PRO A CD  1 
ATOM 1937 N N   . ARG A 1 259 ? 57.925 33.881 49.174 1.00 0.52 ? 259 ARG A N   1 
ATOM 1938 C CA  . ARG A 1 259 ? 58.315 34.919 50.121 1.00 0.52 ? 259 ARG A CA  1 
ATOM 1939 C C   . ARG A 1 259 ? 59.378 34.509 51.126 1.00 0.52 ? 259 ARG A C   1 
ATOM 1940 O O   . ARG A 1 259 ? 60.300 35.268 51.396 1.00 0.52 ? 259 ARG A O   1 
ATOM 1941 C CB  . ARG A 1 259 ? 57.092 35.452 50.913 1.00 0.52 ? 259 ARG A CB  1 
ATOM 1942 C CG  . ARG A 1 259 ? 55.905 35.972 50.061 1.00 0.52 ? 259 ARG A CG  1 
ATOM 1943 C CD  . ARG A 1 259 ? 56.203 37.169 49.142 1.00 0.52 ? 259 ARG A CD  1 
ATOM 1944 N NE  . ARG A 1 259 ? 54.915 37.483 48.427 1.00 0.52 ? 259 ARG A NE  1 
ATOM 1945 C CZ  . ARG A 1 259 ? 54.473 38.706 48.102 1.00 0.52 ? 259 ARG A CZ  1 
ATOM 1946 N NH1 . ARG A 1 259 ? 53.240 38.866 47.625 1.00 0.52 ? 259 ARG A NH1 1 
ATOM 1947 N NH2 . ARG A 1 259 ? 55.198 39.811 48.213 1.00 0.52 ? 259 ARG A NH2 1 
ATOM 1948 N N   . GLN A 1 260 ? 59.298 33.275 51.650 1.00 0.53 ? 260 GLN A N   1 
ATOM 1949 C CA  . GLN A 1 260 ? 60.215 32.711 52.616 1.00 0.53 ? 260 GLN A CA  1 
ATOM 1950 C C   . GLN A 1 260 ? 61.591 32.355 52.052 1.00 0.53 ? 260 GLN A C   1 
ATOM 1951 O O   . GLN A 1 260 ? 62.515 32.033 52.795 1.00 0.53 ? 260 GLN A O   1 
ATOM 1952 C CB  . GLN A 1 260 ? 59.581 31.461 53.289 1.00 0.53 ? 260 GLN A CB  1 
ATOM 1953 C CG  . GLN A 1 260 ? 59.364 30.194 52.405 1.00 0.53 ? 260 GLN A CG  1 
ATOM 1954 C CD  . GLN A 1 260 ? 58.082 30.190 51.560 1.00 0.53 ? 260 GLN A CD  1 
ATOM 1955 O OE1 . GLN A 1 260 ? 57.527 31.209 51.151 1.00 0.53 ? 260 GLN A OE1 1 
ATOM 1956 N NE2 . GLN A 1 260 ? 57.591 28.964 51.251 1.00 0.53 ? 260 GLN A NE2 1 
ATOM 1957 N N   . LYS A 1 261 ? 61.761 32.381 50.713 1.00 0.53 ? 261 LYS A N   1 
ATOM 1958 C CA  . LYS A 1 261 ? 63.054 32.234 50.076 1.00 0.53 ? 261 LYS A CA  1 
ATOM 1959 C C   . LYS A 1 261 ? 63.632 33.573 49.623 1.00 0.53 ? 261 LYS A C   1 
ATOM 1960 O O   . LYS A 1 261 ? 64.743 33.618 49.089 1.00 0.53 ? 261 LYS A O   1 
ATOM 1961 C CB  . LYS A 1 261 ? 62.933 31.328 48.826 1.00 0.53 ? 261 LYS A CB  1 
ATOM 1962 C CG  . LYS A 1 261 ? 62.803 29.831 49.162 1.00 0.53 ? 261 LYS A CG  1 
ATOM 1963 C CD  . LYS A 1 261 ? 62.826 28.943 47.902 1.00 0.53 ? 261 LYS A CD  1 
ATOM 1964 C CE  . LYS A 1 261 ? 63.115 27.456 48.158 1.00 0.53 ? 261 LYS A CE  1 
ATOM 1965 N NZ  . LYS A 1 261 ? 61.969 26.798 48.823 1.00 0.53 ? 261 LYS A NZ  1 
ATOM 1966 N N   . ARG A 1 262 ? 62.908 34.695 49.809 1.00 0.53 ? 262 ARG A N   1 
ATOM 1967 C CA  . ARG A 1 262 ? 63.403 36.028 49.508 1.00 0.53 ? 262 ARG A CA  1 
ATOM 1968 C C   . ARG A 1 262 ? 64.124 36.656 50.694 1.00 0.53 ? 262 ARG A C   1 
ATOM 1969 O O   . ARG A 1 262 ? 63.767 36.412 51.840 1.00 0.53 ? 262 ARG A O   1 
ATOM 1970 C CB  . ARG A 1 262 ? 62.251 37.010 49.159 1.00 0.53 ? 262 ARG A CB  1 
ATOM 1971 C CG  . ARG A 1 262 ? 61.339 36.548 48.007 1.00 0.53 ? 262 ARG A CG  1 
ATOM 1972 C CD  . ARG A 1 262 ? 60.257 37.571 47.633 1.00 0.53 ? 262 ARG A CD  1 
ATOM 1973 N NE  . ARG A 1 262 ? 59.359 36.899 46.647 1.00 0.53 ? 262 ARG A NE  1 
ATOM 1974 C CZ  . ARG A 1 262 ? 58.470 37.515 45.863 1.00 0.53 ? 262 ARG A CZ  1 
ATOM 1975 N NH1 . ARG A 1 262 ? 57.889 36.814 44.895 1.00 0.53 ? 262 ARG A NH1 1 
ATOM 1976 N NH2 . ARG A 1 262 ? 58.135 38.794 45.973 1.00 0.53 ? 262 ARG A NH2 1 
ATOM 1977 N N   . THR A 1 263 ? 65.116 37.538 50.426 1.00 0.56 ? 263 THR A N   1 
ATOM 1978 C CA  . THR A 1 263 ? 65.796 38.340 51.445 1.00 0.56 ? 263 THR A CA  1 
ATOM 1979 C C   . THR A 1 263 ? 66.218 39.622 50.758 1.00 0.56 ? 263 THR A C   1 
ATOM 1980 O O   . THR A 1 263 ? 66.866 39.581 49.715 1.00 0.56 ? 263 THR A O   1 
ATOM 1981 C CB  . THR A 1 263 ? 67.024 37.666 52.066 1.00 0.56 ? 263 THR A CB  1 
ATOM 1982 O OG1 . THR A 1 263 ? 66.603 36.642 52.950 1.00 0.56 ? 263 THR A OG1 1 
ATOM 1983 C CG2 . THR A 1 263 ? 67.885 38.605 52.928 1.00 0.56 ? 263 THR A CG2 1 
ATOM 1984 N N   . ALA A 1 264 ? 65.826 40.802 51.286 1.00 0.60 ? 264 ALA A N   1 
ATOM 1985 C CA  . ALA A 1 264 ? 66.167 42.093 50.705 1.00 0.60 ? 264 ALA A CA  1 
ATOM 1986 C C   . ALA A 1 264 ? 67.614 42.543 50.934 1.00 0.60 ? 264 ALA A C   1 
ATOM 1987 O O   . ALA A 1 264 ? 68.249 42.217 51.936 1.00 0.60 ? 264 ALA A O   1 
ATOM 1988 C CB  . ALA A 1 264 ? 65.175 43.180 51.166 1.00 0.60 ? 264 ALA A CB  1 
ATOM 1989 N N   . THR A 1 265 ? 68.172 43.321 49.983 1.00 0.56 ? 265 THR A N   1 
ATOM 1990 C CA  . THR A 1 265 ? 69.565 43.767 49.970 1.00 0.56 ? 265 THR A CA  1 
ATOM 1991 C C   . THR A 1 265 ? 69.611 45.125 49.294 1.00 0.56 ? 265 THR A C   1 
ATOM 1992 O O   . THR A 1 265 ? 68.613 45.603 48.763 1.00 0.56 ? 265 THR A O   1 
ATOM 1993 C CB  . THR A 1 265 ? 70.549 42.833 49.226 1.00 0.56 ? 265 THR A CB  1 
ATOM 1994 O OG1 . THR A 1 265 ? 70.305 42.751 47.827 1.00 0.56 ? 265 THR A OG1 1 
ATOM 1995 C CG2 . THR A 1 265 ? 70.462 41.399 49.764 1.00 0.56 ? 265 THR A CG2 1 
ATOM 1996 N N   . LYS A 1 266 ? 70.782 45.798 49.253 1.00 0.51 ? 266 LYS A N   1 
ATOM 1997 C CA  . LYS A 1 266 ? 70.990 47.004 48.457 1.00 0.51 ? 266 LYS A CA  1 
ATOM 1998 C C   . LYS A 1 266 ? 70.761 46.804 46.950 1.00 0.51 ? 266 LYS A C   1 
ATOM 1999 O O   . LYS A 1 266 ? 70.365 47.724 46.235 1.00 0.51 ? 266 LYS A O   1 
ATOM 2000 C CB  . LYS A 1 266 ? 72.416 47.566 48.712 1.00 0.51 ? 266 LYS A CB  1 
ATOM 2001 C CG  . LYS A 1 266 ? 72.711 48.926 48.044 1.00 0.51 ? 266 LYS A CG  1 
ATOM 2002 C CD  . LYS A 1 266 ? 74.069 49.514 48.476 1.00 0.51 ? 266 LYS A CD  1 
ATOM 2003 C CE  . LYS A 1 266 ? 74.362 50.926 47.953 1.00 0.51 ? 266 LYS A CE  1 
ATOM 2004 N NZ  . LYS A 1 266 ? 74.582 50.885 46.491 1.00 0.51 ? 266 LYS A NZ  1 
ATOM 2005 N N   . ALA A 1 267 ? 71.008 45.579 46.439 1.00 0.52 ? 267 ALA A N   1 
ATOM 2006 C CA  . ALA A 1 267 ? 70.744 45.180 45.072 1.00 0.52 ? 267 ALA A CA  1 
ATOM 2007 C C   . ALA A 1 267 ? 69.290 44.745 44.822 1.00 0.52 ? 267 ALA A C   1 
ATOM 2008 O O   . ALA A 1 267 ? 68.847 44.659 43.677 1.00 0.52 ? 267 ALA A O   1 
ATOM 2009 C CB  . ALA A 1 267 ? 71.697 44.013 44.734 1.00 0.52 ? 267 ALA A CB  1 
ATOM 2010 N N   . TYR A 1 268 ? 68.499 44.471 45.880 1.00 0.46 ? 268 TYR A N   1 
ATOM 2011 C CA  . TYR A 1 268 ? 67.125 44.030 45.750 1.00 0.46 ? 268 TYR A CA  1 
ATOM 2012 C C   . TYR A 1 268 ? 66.332 44.592 46.925 1.00 0.46 ? 268 TYR A C   1 
ATOM 2013 O O   . TYR A 1 268 ? 66.301 44.031 48.018 1.00 0.46 ? 268 TYR A O   1 
ATOM 2014 C CB  . TYR A 1 268 ? 67.065 42.477 45.693 1.00 0.46 ? 268 TYR A CB  1 
ATOM 2015 C CG  . TYR A 1 268 ? 65.666 41.941 45.570 1.00 0.46 ? 268 TYR A CG  1 
ATOM 2016 C CD1 . TYR A 1 268 ? 64.928 42.103 44.387 1.00 0.46 ? 268 TYR A CD1 1 
ATOM 2017 C CD2 . TYR A 1 268 ? 65.081 41.263 46.651 1.00 0.46 ? 268 TYR A CD2 1 
ATOM 2018 C CE1 . TYR A 1 268 ? 63.640 41.562 44.278 1.00 0.46 ? 268 TYR A CE1 1 
ATOM 2019 C CE2 . TYR A 1 268 ? 63.785 40.748 46.551 1.00 0.46 ? 268 TYR A CE2 1 
ATOM 2020 C CZ  . TYR A 1 268 ? 63.077 40.883 45.356 1.00 0.46 ? 268 TYR A CZ  1 
ATOM 2021 O OH  . TYR A 1 268 ? 61.816 40.285 45.235 1.00 0.46 ? 268 TYR A OH  1 
ATOM 2022 N N   . ASN A 1 269 ? 65.689 45.761 46.731 1.00 0.57 ? 269 ASN A N   1 
ATOM 2023 C CA  . ASN A 1 269 ? 65.001 46.499 47.781 1.00 0.57 ? 269 ASN A CA  1 
ATOM 2024 C C   . ASN A 1 269 ? 63.804 45.789 48.435 1.00 0.57 ? 269 ASN A C   1 
ATOM 2025 O O   . ASN A 1 269 ? 63.142 44.943 47.835 1.00 0.57 ? 269 ASN A O   1 
ATOM 2026 C CB  . ASN A 1 269 ? 64.590 47.918 47.300 1.00 0.57 ? 269 ASN A CB  1 
ATOM 2027 C CG  . ASN A 1 269 ? 65.807 48.839 47.243 1.00 0.57 ? 269 ASN A CG  1 
ATOM 2028 O OD1 . ASN A 1 269 ? 66.431 49.132 48.264 1.00 0.57 ? 269 ASN A OD1 1 
ATOM 2029 N ND2 . ASN A 1 269 ? 66.160 49.357 46.047 1.00 0.57 ? 269 ASN A ND2 1 
ATOM 2030 N N   . VAL A 1 270 ? 63.476 46.158 49.702 1.00 0.62 ? 270 VAL A N   1 
ATOM 2031 C CA  . VAL A 1 270 ? 62.339 45.647 50.481 1.00 0.62 ? 270 VAL A CA  1 
ATOM 2032 C C   . VAL A 1 270 ? 61.009 45.821 49.751 1.00 0.62 ? 270 VAL A C   1 
ATOM 2033 O O   . VAL A 1 270 ? 60.151 44.944 49.771 1.00 0.62 ? 270 VAL A O   1 
ATOM 2034 C CB  . VAL A 1 270 ? 62.270 46.321 51.859 1.00 0.62 ? 270 VAL A CB  1 
ATOM 2035 C CG1 . VAL A 1 270 ? 61.011 45.910 52.657 1.00 0.62 ? 270 VAL A CG1 1 
ATOM 2036 C CG2 . VAL A 1 270 ? 63.520 45.954 52.686 1.00 0.62 ? 270 VAL A CG2 1 
ATOM 2037 N N   . THR A 1 271 ? 60.871 46.946 49.022 1.00 0.54 ? 271 THR A N   1 
ATOM 2038 C CA  . THR A 1 271 ? 59.768 47.292 48.135 1.00 0.54 ? 271 THR A CA  1 
ATOM 2039 C C   . THR A 1 271 ? 59.530 46.311 46.994 1.00 0.54 ? 271 THR A C   1 
ATOM 2040 O O   . THR A 1 271 ? 58.413 46.168 46.511 1.00 0.54 ? 271 THR A O   1 
ATOM 2041 C CB  . THR A 1 271 ? 59.955 48.680 47.521 1.00 0.54 ? 271 THR A CB  1 
ATOM 2042 O OG1 . THR A 1 271 ? 61.220 48.833 46.885 1.00 0.54 ? 271 THR A OG1 1 
ATOM 2043 C CG2 . THR A 1 271 ? 59.916 49.755 48.614 1.00 0.54 ? 271 THR A CG2 1 
ATOM 2044 N N   . GLN A 1 272 ? 60.579 45.611 46.508 1.00 0.53 ? 272 GLN A N   1 
ATOM 2045 C CA  . GLN A 1 272 ? 60.433 44.579 45.498 1.00 0.53 ? 272 GLN A CA  1 
ATOM 2046 C C   . GLN A 1 272 ? 60.061 43.234 46.111 1.00 0.53 ? 272 GLN A C   1 
ATOM 2047 O O   . GLN A 1 272 ? 59.317 42.437 45.542 1.00 0.53 ? 272 GLN A O   1 
ATOM 2048 C CB  . GLN A 1 272 ? 61.727 44.448 44.665 1.00 0.53 ? 272 GLN A CB  1 
ATOM 2049 C CG  . GLN A 1 272 ? 62.121 45.765 43.956 1.00 0.53 ? 272 GLN A CG  1 
ATOM 2050 C CD  . GLN A 1 272 ? 63.260 45.548 42.957 1.00 0.53 ? 272 GLN A CD  1 
ATOM 2051 O OE1 . GLN A 1 272 ? 63.493 44.461 42.424 1.00 0.53 ? 272 GLN A OE1 1 
ATOM 2052 N NE2 . GLN A 1 272 ? 64.022 46.632 42.679 1.00 0.53 ? 272 GLN A NE2 1 
ATOM 2053 N N   . ALA A 1 273 ? 60.563 42.945 47.331 1.00 0.57 ? 273 ALA A N   1 
ATOM 2054 C CA  . ALA A 1 273 ? 60.183 41.769 48.084 1.00 0.57 ? 273 ALA A CA  1 
ATOM 2055 C C   . ALA A 1 273 ? 58.712 41.743 48.503 1.00 0.57 ? 273 ALA A C   1 
ATOM 2056 O O   . ALA A 1 273 ? 58.054 40.697 48.417 1.00 0.57 ? 273 ALA A O   1 
ATOM 2057 C CB  . ALA A 1 273 ? 61.091 41.618 49.323 1.00 0.57 ? 273 ALA A CB  1 
ATOM 2058 N N   . PHE A 1 274 ? 58.191 42.905 48.948 1.00 0.50 ? 274 PHE A N   1 
ATOM 2059 C CA  . PHE A 1 274 ? 56.854 43.082 49.466 1.00 0.50 ? 274 PHE A CA  1 
ATOM 2060 C C   . PHE A 1 274 ? 56.314 44.441 49.053 1.00 0.50 ? 274 PHE A C   1 
ATOM 2061 O O   . PHE A 1 274 ? 57.022 45.441 49.135 1.00 0.50 ? 274 PHE A O   1 
ATOM 2062 C CB  . PHE A 1 274 ? 56.853 43.114 51.020 1.00 0.50 ? 274 PHE A CB  1 
ATOM 2063 C CG  . PHE A 1 274 ? 57.486 41.900 51.630 1.00 0.50 ? 274 PHE A CG  1 
ATOM 2064 C CD1 . PHE A 1 274 ? 56.917 40.631 51.457 1.00 0.50 ? 274 PHE A CD1 1 
ATOM 2065 C CD2 . PHE A 1 274 ? 58.641 42.022 52.419 1.00 0.50 ? 274 PHE A CD2 1 
ATOM 2066 C CE1 . PHE A 1 274 ? 57.472 39.508 52.083 1.00 0.50 ? 274 PHE A CE1 1 
ATOM 2067 C CE2 . PHE A 1 274 ? 59.211 40.900 53.032 1.00 0.50 ? 274 PHE A CE2 1 
ATOM 2068 C CZ  . PHE A 1 274 ? 58.621 39.641 52.867 1.00 0.50 ? 274 PHE A CZ  1 
ATOM 2069 N N   . GLY A 1 275 ? 55.031 44.512 48.639 1.00 0.56 ? 275 GLY A N   1 
ATOM 2070 C CA  . GLY A 1 275 ? 54.356 45.778 48.353 1.00 0.56 ? 275 GLY A CA  1 
ATOM 2071 C C   . GLY A 1 275 ? 53.935 46.578 49.558 1.00 0.56 ? 275 GLY A C   1 
ATOM 2072 O O   . GLY A 1 275 ? 54.515 46.514 50.642 1.00 0.56 ? 275 GLY A O   1 
ATOM 2073 N N   . ARG A 1 276 ? 52.871 47.392 49.390 1.00 0.45 ? 276 ARG A N   1 
ATOM 2074 C CA  . ARG A 1 276 ? 52.325 48.207 50.462 1.00 0.45 ? 276 ARG A CA  1 
ATOM 2075 C C   . ARG A 1 276 ? 51.866 47.398 51.680 1.00 0.45 ? 276 ARG A C   1 
ATOM 2076 O O   . ARG A 1 276 ? 51.022 46.513 51.575 1.00 0.45 ? 276 ARG A O   1 
ATOM 2077 C CB  . ARG A 1 276 ? 51.156 49.096 49.957 1.00 0.45 ? 276 ARG A CB  1 
ATOM 2078 C CG  . ARG A 1 276 ? 50.921 50.370 50.798 1.00 0.45 ? 276 ARG A CG  1 
ATOM 2079 C CD  . ARG A 1 276 ? 49.738 51.233 50.326 1.00 0.45 ? 276 ARG A CD  1 
ATOM 2080 N NE  . ARG A 1 276 ? 48.462 50.651 50.881 1.00 0.45 ? 276 ARG A NE  1 
ATOM 2081 C CZ  . ARG A 1 276 ? 47.831 51.050 51.994 1.00 0.45 ? 276 ARG A CZ  1 
ATOM 2082 N NH1 . ARG A 1 276 ? 46.721 50.425 52.390 1.00 0.45 ? 276 ARG A NH1 1 
ATOM 2083 N NH2 . ARG A 1 276 ? 48.264 52.084 52.710 1.00 0.45 ? 276 ARG A NH2 1 
ATOM 2084 N N   . ARG A 1 277 ? 52.438 47.674 52.868 1.00 0.50 ? 277 ARG A N   1 
ATOM 2085 C CA  . ARG A 1 277 ? 52.240 46.867 54.063 1.00 0.50 ? 277 ARG A CA  1 
ATOM 2086 C C   . ARG A 1 277 ? 51.036 47.267 54.918 1.00 0.50 ? 277 ARG A C   1 
ATOM 2087 O O   . ARG A 1 277 ? 50.419 48.317 54.731 1.00 0.50 ? 277 ARG A O   1 
ATOM 2088 C CB  . ARG A 1 277 ? 53.547 46.891 54.899 1.00 0.50 ? 277 ARG A CB  1 
ATOM 2089 C CG  . ARG A 1 277 ? 54.616 45.925 54.340 1.00 0.50 ? 277 ARG A CG  1 
ATOM 2090 C CD  . ARG A 1 277 ? 56.071 46.256 54.696 1.00 0.50 ? 277 ARG A CD  1 
ATOM 2091 N NE  . ARG A 1 277 ? 56.198 46.265 56.193 1.00 0.50 ? 277 ARG A NE  1 
ATOM 2092 C CZ  . ARG A 1 277 ? 56.754 47.244 56.916 1.00 0.50 ? 277 ARG A CZ  1 
ATOM 2093 N NH1 . ARG A 1 277 ? 56.898 47.147 58.237 1.00 0.50 ? 277 ARG A NH1 1 
ATOM 2094 N NH2 . ARG A 1 277 ? 57.238 48.347 56.352 1.00 0.50 ? 277 ARG A NH2 1 
ATOM 2095 N N   . GLY A 1 278 ? 50.666 46.413 55.899 1.00 0.56 ? 278 GLY A N   1 
ATOM 2096 C CA  . GLY A 1 278 ? 49.468 46.616 56.697 1.00 0.56 ? 278 GLY A CA  1 
ATOM 2097 C C   . GLY A 1 278 ? 49.264 45.438 57.614 1.00 0.56 ? 278 GLY A C   1 
ATOM 2098 O O   . GLY A 1 278 ? 50.195 44.655 57.799 1.00 0.56 ? 278 GLY A O   1 
ATOM 2099 N N   . PRO A 1 279 ? 48.082 45.254 58.205 1.00 0.51 ? 279 PRO A N   1 
ATOM 2100 C CA  . PRO A 1 279 ? 47.777 44.112 59.063 1.00 0.51 ? 279 PRO A CA  1 
ATOM 2101 C C   . PRO A 1 279 ? 47.501 42.862 58.227 1.00 0.51 ? 279 PRO A C   1 
ATOM 2102 O O   . PRO A 1 279 ? 46.380 42.359 58.216 1.00 0.51 ? 279 PRO A O   1 
ATOM 2103 C CB  . PRO A 1 279 ? 46.517 44.588 59.819 1.00 0.51 ? 279 PRO A CB  1 
ATOM 2104 C CG  . PRO A 1 279 ? 45.809 45.523 58.835 1.00 0.51 ? 279 PRO A CG  1 
ATOM 2105 C CD  . PRO A 1 279 ? 46.963 46.188 58.092 1.00 0.51 ? 279 PRO A CD  1 
ATOM 2106 N N   . GLU A 1 280 ? 48.526 42.342 57.528 1.00 0.53 ? 280 GLU A N   1 
ATOM 2107 C CA  . GLU A 1 280 ? 48.383 41.344 56.490 1.00 0.53 ? 280 GLU A CA  1 
ATOM 2108 C C   . GLU A 1 280 ? 49.488 40.313 56.635 1.00 0.53 ? 280 GLU A C   1 
ATOM 2109 O O   . GLU A 1 280 ? 50.620 40.635 56.974 1.00 0.53 ? 280 GLU A O   1 
ATOM 2110 C CB  . GLU A 1 280 ? 48.445 42.003 55.084 1.00 0.53 ? 280 GLU A CB  1 
ATOM 2111 C CG  . GLU A 1 280 ? 47.300 43.028 54.858 1.00 0.53 ? 280 GLU A CG  1 
ATOM 2112 C CD  . GLU A 1 280 ? 47.147 43.538 53.423 1.00 0.53 ? 280 GLU A CD  1 
ATOM 2113 O OE1 . GLU A 1 280 ? 46.895 42.691 52.526 1.00 0.53 ? 280 GLU A OE1 1 
ATOM 2114 O OE2 . GLU A 1 280 ? 47.220 44.783 53.239 1.00 0.53 ? 280 GLU A OE2 1 
ATOM 2115 N N   . GLN A 1 281 ? 49.164 39.015 56.442 1.00 0.54 ? 281 GLN A N   1 
ATOM 2116 C CA  . GLN A 1 281 ? 50.081 37.925 56.742 1.00 0.54 ? 281 GLN A CA  1 
ATOM 2117 C C   . GLN A 1 281 ? 51.146 37.632 55.692 1.00 0.54 ? 281 GLN A C   1 
ATOM 2118 O O   . GLN A 1 281 ? 52.217 37.133 56.013 1.00 0.54 ? 281 GLN A O   1 
ATOM 2119 C CB  . GLN A 1 281 ? 49.266 36.640 57.018 1.00 0.54 ? 281 GLN A CB  1 
ATOM 2120 C CG  . GLN A 1 281 ? 50.081 35.442 57.572 1.00 0.54 ? 281 GLN A CG  1 
ATOM 2121 C CD  . GLN A 1 281 ? 49.127 34.357 58.064 1.00 0.54 ? 281 GLN A CD  1 
ATOM 2122 O OE1 . GLN A 1 281 ? 47.926 34.406 57.806 1.00 0.54 ? 281 GLN A OE1 1 
ATOM 2123 N NE2 . GLN A 1 281 ? 49.639 33.369 58.828 1.00 0.54 ? 281 GLN A NE2 1 
ATOM 2124 N N   . THR A 1 282 ? 50.882 37.898 54.398 1.00 0.56 ? 282 THR A N   1 
ATOM 2125 C CA  . THR A 1 282 ? 51.802 37.567 53.307 1.00 0.56 ? 282 THR A CA  1 
ATOM 2126 C C   . THR A 1 282 ? 53.031 38.453 53.224 1.00 0.56 ? 282 THR A C   1 
ATOM 2127 O O   . THR A 1 282 ? 54.143 38.003 52.934 1.00 0.56 ? 282 THR A O   1 
ATOM 2128 C CB  . THR A 1 282 ? 51.089 37.576 51.966 1.00 0.56 ? 282 THR A CB  1 
ATOM 2129 O OG1 . THR A 1 282 ? 50.052 36.606 51.976 1.00 0.56 ? 282 THR A OG1 1 
ATOM 2130 C CG2 . THR A 1 282 ? 51.991 37.208 50.778 1.00 0.56 ? 282 THR A CG2 1 
ATOM 2131 N N   . GLN A 1 283 ? 52.852 39.766 53.437 1.00 0.53 ? 283 GLN A N   1 
ATOM 2132 C CA  . GLN A 1 283 ? 53.900 40.758 53.414 1.00 0.53 ? 283 GLN A CA  1 
ATOM 2133 C C   . GLN A 1 283 ? 54.662 40.807 54.728 1.00 0.53 ? 283 GLN A C   1 
ATOM 2134 O O   . GLN A 1 283 ? 54.133 40.587 55.812 1.00 0.53 ? 283 GLN A O   1 
ATOM 2135 C CB  . GLN A 1 283 ? 53.357 42.170 53.055 1.00 0.53 ? 283 GLN A CB  1 
ATOM 2136 C CG  . GLN A 1 283 ? 52.916 42.351 51.574 1.00 0.53 ? 283 GLN A CG  1 
ATOM 2137 C CD  . GLN A 1 283 ? 51.706 41.493 51.187 1.00 0.53 ? 283 GLN A CD  1 
ATOM 2138 O OE1 . GLN A 1 283 ? 50.855 41.151 52.012 1.00 0.53 ? 283 GLN A OE1 1 
ATOM 2139 N NE2 . GLN A 1 283 ? 51.643 41.094 49.898 1.00 0.53 ? 283 GLN A NE2 1 
ATOM 2140 N N   . GLY A 1 284 ? 55.980 41.087 54.666 1.00 0.59 ? 284 GLY A N   1 
ATOM 2141 C CA  . GLY A 1 284 ? 56.815 41.159 55.856 1.00 0.59 ? 284 GLY A CA  1 
ATOM 2142 C C   . GLY A 1 284 ? 56.456 42.216 56.873 1.00 0.59 ? 284 GLY A C   1 
ATOM 2143 O O   . GLY A 1 284 ? 56.136 43.365 56.561 1.00 0.59 ? 284 GLY A O   1 
ATOM 2144 N N   . ASN A 1 285 ? 56.606 41.868 58.165 1.00 0.58 ? 285 ASN A N   1 
ATOM 2145 C CA  . ASN A 1 285 ? 56.263 42.752 59.266 1.00 0.58 ? 285 ASN A CA  1 
ATOM 2146 C C   . ASN A 1 285 ? 57.246 43.908 59.440 1.00 0.58 ? 285 ASN A C   1 
ATOM 2147 O O   . ASN A 1 285 ? 56.943 44.917 60.075 1.00 0.58 ? 285 ASN A O   1 
ATOM 2148 C CB  . ASN A 1 285 ? 56.237 41.971 60.604 1.00 0.58 ? 285 ASN A CB  1 
ATOM 2149 C CG  . ASN A 1 285 ? 55.101 40.961 60.604 1.00 0.58 ? 285 ASN A CG  1 
ATOM 2150 O OD1 . ASN A 1 285 ? 53.940 41.331 60.474 1.00 0.58 ? 285 ASN A OD1 1 
ATOM 2151 N ND2 . ASN A 1 285 ? 55.410 39.658 60.792 1.00 0.58 ? 285 ASN A ND2 1 
ATOM 2152 N N   . PHE A 1 286 ? 58.457 43.801 58.862 1.00 0.58 ? 286 PHE A N   1 
ATOM 2153 C CA  . PHE A 1 286 ? 59.634 44.514 59.319 1.00 0.58 ? 286 PHE A CA  1 
ATOM 2154 C C   . PHE A 1 286 ? 60.083 45.615 58.353 1.00 0.58 ? 286 PHE A C   1 
ATOM 2155 O O   . PHE A 1 286 ? 60.219 45.392 57.153 1.00 0.58 ? 286 PHE A O   1 
ATOM 2156 C CB  . PHE A 1 286 ? 60.808 43.508 59.530 1.00 0.58 ? 286 PHE A CB  1 
ATOM 2157 C CG  . PHE A 1 286 ? 60.346 42.234 60.195 1.00 0.58 ? 286 PHE A CG  1 
ATOM 2158 C CD1 . PHE A 1 286 ? 59.986 42.219 61.552 1.00 0.58 ? 286 PHE A CD1 1 
ATOM 2159 C CD2 . PHE A 1 286 ? 60.255 41.037 59.461 1.00 0.58 ? 286 PHE A CD2 1 
ATOM 2160 C CE1 . PHE A 1 286 ? 59.542 41.037 62.163 1.00 0.58 ? 286 PHE A CE1 1 
ATOM 2161 C CE2 . PHE A 1 286 ? 59.808 39.858 60.067 1.00 0.58 ? 286 PHE A CE2 1 
ATOM 2162 C CZ  . PHE A 1 286 ? 59.450 39.856 61.417 1.00 0.58 ? 286 PHE A CZ  1 
ATOM 2163 N N   . GLY A 1 287 ? 60.328 46.850 58.861 1.00 0.66 ? 287 GLY A N   1 
ATOM 2164 C CA  . GLY A 1 287 ? 60.866 47.966 58.073 1.00 0.66 ? 287 GLY A CA  1 
ATOM 2165 C C   . GLY A 1 287 ? 60.036 49.216 58.189 1.00 0.66 ? 287 GLY A C   1 
ATOM 2166 O O   . GLY A 1 287 ? 58.843 49.151 58.481 1.00 0.66 ? 287 GLY A O   1 
ATOM 2167 N N   . ASP A 1 288 ? 60.637 50.392 57.925 1.00 0.69 ? 288 ASP A N   1 
ATOM 2168 C CA  . ASP A 1 288 ? 60.001 51.675 58.108 1.00 0.69 ? 288 ASP A CA  1 
ATOM 2169 C C   . ASP A 1 288 ? 60.388 52.600 56.944 1.00 0.69 ? 288 ASP A C   1 
ATOM 2170 O O   . ASP A 1 288 ? 61.315 52.298 56.194 1.00 0.69 ? 288 ASP A O   1 
ATOM 2171 C CB  . ASP A 1 288 ? 60.414 52.261 59.481 1.00 0.69 ? 288 ASP A CB  1 
ATOM 2172 C CG  . ASP A 1 288 ? 59.441 53.336 59.898 1.00 0.69 ? 288 ASP A CG  1 
ATOM 2173 O OD1 . ASP A 1 288 ? 58.414 53.520 59.198 1.00 0.69 ? 288 ASP A OD1 1 
ATOM 2174 O OD2 . ASP A 1 288 ? 59.684 53.964 60.953 1.00 0.69 ? 288 ASP A OD2 1 
ATOM 2175 N N   . GLN A 1 289 ? 59.679 53.738 56.761 1.00 0.69 ? 289 GLN A N   1 
ATOM 2176 C CA  . GLN A 1 289 ? 59.790 54.669 55.637 1.00 0.69 ? 289 GLN A CA  1 
ATOM 2177 C C   . GLN A 1 289 ? 61.158 55.332 55.494 1.00 0.69 ? 289 GLN A C   1 
ATOM 2178 O O   . GLN A 1 289 ? 61.561 55.709 54.394 1.00 0.69 ? 289 GLN A O   1 
ATOM 2179 C CB  . GLN A 1 289 ? 58.679 55.753 55.659 1.00 0.69 ? 289 GLN A CB  1 
ATOM 2180 C CG  . GLN A 1 289 ? 57.261 55.223 55.317 1.00 0.69 ? 289 GLN A CG  1 
ATOM 2181 C CD  . GLN A 1 289 ? 56.998 55.085 53.812 1.00 0.69 ? 289 GLN A CD  1 
ATOM 2182 O OE1 . GLN A 1 289 ? 57.599 54.284 53.091 1.00 0.69 ? 289 GLN A OE1 1 
ATOM 2183 N NE2 . GLN A 1 289 ? 56.034 55.882 53.298 1.00 0.69 ? 289 GLN A NE2 1 
ATOM 2184 N N   . GLU A 1 290 ? 61.939 55.456 56.584 1.00 0.66 ? 290 GLU A N   1 
ATOM 2185 C CA  . GLU A 1 290 ? 63.320 55.909 56.544 1.00 0.66 ? 290 GLU A CA  1 
ATOM 2186 C C   . GLU A 1 290 ? 64.233 55.036 55.686 1.00 0.66 ? 290 GLU A C   1 
ATOM 2187 O O   . GLU A 1 290 ? 65.016 55.540 54.877 1.00 0.66 ? 290 GLU A O   1 
ATOM 2188 C CB  . GLU A 1 290 ? 63.884 55.953 57.973 1.00 0.66 ? 290 GLU A CB  1 
ATOM 2189 C CG  . GLU A 1 290 ? 63.253 57.046 58.858 1.00 0.66 ? 290 GLU A CG  1 
ATOM 2190 C CD  . GLU A 1 290 ? 63.941 57.020 60.219 1.00 0.66 ? 290 GLU A CD  1 
ATOM 2191 O OE1 . GLU A 1 290 ? 63.815 56.007 60.952 1.00 0.66 ? 290 GLU A OE1 1 
ATOM 2192 O OE2 . GLU A 1 290 ? 64.689 57.995 60.483 1.00 0.66 ? 290 GLU A OE2 1 
ATOM 2193 N N   . LEU A 1 291 ? 64.100 53.695 55.811 1.00 0.65 ? 291 LEU A N   1 
ATOM 2194 C CA  . LEU A 1 291 ? 64.738 52.709 54.952 1.00 0.65 ? 291 LEU A CA  1 
ATOM 2195 C C   . LEU A 1 291 ? 64.231 52.788 53.529 1.00 0.65 ? 291 LEU A C   1 
ATOM 2196 O O   . LEU A 1 291 ? 65.000 52.742 52.580 1.00 0.65 ? 291 LEU A O   1 
ATOM 2197 C CB  . LEU A 1 291 ? 64.549 51.277 55.521 1.00 0.65 ? 291 LEU A CB  1 
ATOM 2198 C CG  . LEU A 1 291 ? 65.198 50.119 54.719 1.00 0.65 ? 291 LEU A CG  1 
ATOM 2199 C CD1 . LEU A 1 291 ? 65.629 48.988 55.662 1.00 0.65 ? 291 LEU A CD1 1 
ATOM 2200 C CD2 . LEU A 1 291 ? 64.288 49.520 53.626 1.00 0.65 ? 291 LEU A CD2 1 
ATOM 2201 N N   . ILE A 1 292 ? 62.907 52.950 53.332 1.00 0.60 ? 292 ILE A N   1 
ATOM 2202 C CA  . ILE A 1 292 ? 62.305 53.055 52.008 1.00 0.60 ? 292 ILE A CA  1 
ATOM 2203 C C   . ILE A 1 292 ? 62.824 54.270 51.237 1.00 0.60 ? 292 ILE A C   1 
ATOM 2204 O O   . ILE A 1 292 ? 63.097 54.205 50.041 1.00 0.60 ? 292 ILE A O   1 
ATOM 2205 C CB  . ILE A 1 292 ? 60.778 53.048 52.085 1.00 0.60 ? 292 ILE A CB  1 
ATOM 2206 C CG1 . ILE A 1 292 ? 60.225 51.869 52.937 1.00 0.60 ? 292 ILE A CG1 1 
ATOM 2207 C CG2 . ILE A 1 292 ? 60.149 53.036 50.676 1.00 0.60 ? 292 ILE A CG2 1 
ATOM 2208 C CD1 . ILE A 1 292 ? 60.550 50.463 52.418 1.00 0.60 ? 292 ILE A CD1 1 
ATOM 2209 N N   . ARG A 1 293 ? 63.010 55.416 51.923 1.00 0.48 ? 293 ARG A N   1 
ATOM 2210 C CA  . ARG A 1 293 ? 63.650 56.594 51.366 1.00 0.48 ? 293 ARG A CA  1 
ATOM 2211 C C   . ARG A 1 293 ? 65.142 56.498 51.064 1.00 0.48 ? 293 ARG A C   1 
ATOM 2212 O O   . ARG A 1 293 ? 65.583 57.014 50.042 1.00 0.48 ? 293 ARG A O   1 
ATOM 2213 C CB  . ARG A 1 293 ? 63.433 57.802 52.305 1.00 0.48 ? 293 ARG A CB  1 
ATOM 2214 C CG  . ARG A 1 293 ? 62.021 58.417 52.229 1.00 0.48 ? 293 ARG A CG  1 
ATOM 2215 C CD  . ARG A 1 293 ? 61.866 59.538 51.188 1.00 0.48 ? 293 ARG A CD  1 
ATOM 2216 N NE  . ARG A 1 293 ? 61.932 58.963 49.798 1.00 0.48 ? 293 ARG A NE  1 
ATOM 2217 C CZ  . ARG A 1 293 ? 60.872 58.616 49.054 1.00 0.48 ? 293 ARG A CZ  1 
ATOM 2218 N NH1 . ARG A 1 293 ? 61.032 58.218 47.793 1.00 0.48 ? 293 ARG A NH1 1 
ATOM 2219 N NH2 . ARG A 1 293 ? 59.631 58.654 49.521 1.00 0.48 ? 293 ARG A NH2 1 
ATOM 2220 N N   . GLN A 1 294 ? 65.957 55.884 51.949 1.00 0.47 ? 294 GLN A N   1 
ATOM 2221 C CA  . GLN A 1 294 ? 67.390 55.720 51.726 1.00 0.47 ? 294 GLN A CA  1 
ATOM 2222 C C   . GLN A 1 294 ? 67.720 54.581 50.762 1.00 0.47 ? 294 GLN A C   1 
ATOM 2223 O O   . GLN A 1 294 ? 68.791 54.530 50.157 1.00 0.47 ? 294 GLN A O   1 
ATOM 2224 C CB  . GLN A 1 294 ? 68.092 55.458 53.093 1.00 0.47 ? 294 GLN A CB  1 
ATOM 2225 C CG  . GLN A 1 294 ? 69.618 55.158 53.063 1.00 0.47 ? 294 GLN A CG  1 
ATOM 2226 C CD  . GLN A 1 294 ? 70.457 56.262 52.415 1.00 0.47 ? 294 GLN A CD  1 
ATOM 2227 O OE1 . GLN A 1 294 ? 70.071 57.436 52.347 1.00 0.47 ? 294 GLN A OE1 1 
ATOM 2228 N NE2 . GLN A 1 294 ? 71.670 55.886 51.949 1.00 0.47 ? 294 GLN A NE2 1 
ATOM 2229 N N   . GLY A 1 295 ? 66.784 53.634 50.581 1.00 0.55 ? 295 GLY A N   1 
ATOM 2230 C CA  . GLY A 1 295 ? 67.048 52.325 50.010 1.00 0.55 ? 295 GLY A CA  1 
ATOM 2231 C C   . GLY A 1 295 ? 67.592 51.378 51.049 1.00 0.55 ? 295 GLY A C   1 
ATOM 2232 O O   . GLY A 1 295 ? 67.953 51.748 52.166 1.00 0.55 ? 295 GLY A O   1 
ATOM 2233 N N   . THR A 1 296 ? 67.703 50.084 50.695 1.00 0.56 ? 296 THR A N   1 
ATOM 2234 C CA  . THR A 1 296 ? 68.022 49.010 51.646 1.00 0.56 ? 296 THR A CA  1 
ATOM 2235 C C   . THR A 1 296 ? 69.514 48.952 52.025 1.00 0.56 ? 296 THR A C   1 
ATOM 2236 O O   . THR A 1 296 ? 69.974 48.120 52.800 1.00 0.56 ? 296 THR A O   1 
ATOM 2237 C CB  . THR A 1 296 ? 67.539 47.668 51.101 1.00 0.56 ? 296 THR A CB  1 
ATOM 2238 O OG1 . THR A 1 296 ? 66.162 47.690 50.778 1.00 0.56 ? 296 THR A OG1 1 
ATOM 2239 C CG2 . THR A 1 296 ? 67.624 46.489 52.070 1.00 0.56 ? 296 THR A CG2 1 
ATOM 2240 N N   . ASP A 1 297 ? 70.297 49.944 51.552 1.00 0.54 ? 297 ASP A N   1 
ATOM 2241 C CA  . ASP A 1 297 ? 71.584 50.394 52.061 1.00 0.54 ? 297 ASP A CA  1 
ATOM 2242 C C   . ASP A 1 297 ? 71.493 50.796 53.537 1.00 0.54 ? 297 ASP A C   1 
ATOM 2243 O O   . ASP A 1 297 ? 72.434 50.594 54.300 1.00 0.54 ? 297 ASP A O   1 
ATOM 2244 C CB  . ASP A 1 297 ? 71.980 51.599 51.163 1.00 0.54 ? 297 ASP A CB  1 
ATOM 2245 C CG  . ASP A 1 297 ? 73.274 52.298 51.553 1.00 0.54 ? 297 ASP A CG  1 
ATOM 2246 O OD1 . ASP A 1 297 ? 74.350 51.692 51.319 1.00 0.54 ? 297 ASP A OD1 1 
ATOM 2247 O OD2 . ASP A 1 297 ? 73.184 53.476 51.996 1.00 0.54 ? 297 ASP A OD2 1 
ATOM 2248 N N   . TYR A 1 298 ? 70.339 51.375 53.956 1.00 0.56 ? 298 TYR A N   1 
ATOM 2249 C CA  . TYR A 1 298 ? 70.056 51.858 55.296 1.00 0.56 ? 298 TYR A CA  1 
ATOM 2250 C C   . TYR A 1 298 ? 70.676 51.078 56.464 1.00 0.56 ? 298 TYR A C   1 
ATOM 2251 O O   . TYR A 1 298 ? 70.402 49.896 56.676 1.00 0.56 ? 298 TYR A O   1 
ATOM 2252 C CB  . TYR A 1 298 ? 68.521 52.017 55.462 1.00 0.56 ? 298 TYR A CB  1 
ATOM 2253 C CG  . TYR A 1 298 ? 68.103 52.710 56.731 1.00 0.56 ? 298 TYR A CG  1 
ATOM 2254 C CD1 . TYR A 1 298 ? 68.197 54.105 56.867 1.00 0.56 ? 298 TYR A CD1 1 
ATOM 2255 C CD2 . TYR A 1 298 ? 67.578 51.958 57.793 1.00 0.56 ? 298 TYR A CD2 1 
ATOM 2256 C CE1 . TYR A 1 298 ? 67.790 54.730 58.052 1.00 0.56 ? 298 TYR A CE1 1 
ATOM 2257 C CE2 . TYR A 1 298 ? 67.158 52.586 58.972 1.00 0.56 ? 298 TYR A CE2 1 
ATOM 2258 C CZ  . TYR A 1 298 ? 67.294 53.969 59.111 1.00 0.56 ? 298 TYR A CZ  1 
ATOM 2259 O OH  . TYR A 1 298 ? 66.959 54.608 60.316 1.00 0.56 ? 298 TYR A OH  1 
ATOM 2260 N N   . LYS A 1 299 ? 71.487 51.774 57.294 1.00 0.64 ? 299 LYS A N   1 
ATOM 2261 C CA  . LYS A 1 299 ? 72.378 51.185 58.293 1.00 0.64 ? 299 LYS A CA  1 
ATOM 2262 C C   . LYS A 1 299 ? 71.786 50.154 59.257 1.00 0.64 ? 299 LYS A C   1 
ATOM 2263 O O   . LYS A 1 299 ? 72.470 49.234 59.696 1.00 0.64 ? 299 LYS A O   1 
ATOM 2264 C CB  . LYS A 1 299 ? 73.083 52.289 59.131 1.00 0.64 ? 299 LYS A CB  1 
ATOM 2265 C CG  . LYS A 1 299 ? 74.382 52.804 58.492 1.00 0.64 ? 299 LYS A CG  1 
ATOM 2266 C CD  . LYS A 1 299 ? 75.122 53.796 59.408 1.00 0.64 ? 299 LYS A CD  1 
ATOM 2267 C CE  . LYS A 1 299 ? 76.544 54.124 58.937 1.00 0.64 ? 299 LYS A CE  1 
ATOM 2268 N NZ  . LYS A 1 299 ? 77.189 55.062 59.882 1.00 0.64 ? 299 LYS A NZ  1 
ATOM 2269 N N   . HIS A 1 300 ? 70.496 50.274 59.619 1.00 0.67 ? 300 HIS A N   1 
ATOM 2270 C CA  . HIS A 1 300 ? 69.847 49.323 60.508 1.00 0.67 ? 300 HIS A CA  1 
ATOM 2271 C C   . HIS A 1 300 ? 69.490 47.990 59.858 1.00 0.67 ? 300 HIS A C   1 
ATOM 2272 O O   . HIS A 1 300 ? 69.244 47.010 60.561 1.00 0.67 ? 300 HIS A O   1 
ATOM 2273 C CB  . HIS A 1 300 ? 68.548 49.895 61.100 1.00 0.67 ? 300 HIS A CB  1 
ATOM 2274 C CG  . HIS A 1 300 ? 68.748 51.150 61.884 1.00 0.67 ? 300 HIS A CG  1 
ATOM 2275 N ND1 . HIS A 1 300 ? 67.629 51.842 62.303 1.00 0.67 ? 300 HIS A ND1 1 
ATOM 2276 C CD2 . HIS A 1 300 ? 69.880 51.779 62.302 1.00 0.67 ? 300 HIS A CD2 1 
ATOM 2277 C CE1 . HIS A 1 300 ? 68.105 52.880 62.963 1.00 0.67 ? 300 HIS A CE1 1 
ATOM 2278 N NE2 . HIS A 1 300 ? 69.458 52.890 62.994 1.00 0.67 ? 300 HIS A NE2 1 
ATOM 2279 N N   . TRP A 1 301 ? 69.456 47.894 58.509 1.00 0.57 ? 301 TRP A N   1 
ATOM 2280 C CA  . TRP A 1 301 ? 68.971 46.710 57.808 1.00 0.57 ? 301 TRP A CA  1 
ATOM 2281 C C   . TRP A 1 301 ? 69.683 45.390 58.130 1.00 0.57 ? 301 TRP A C   1 
ATOM 2282 O O   . TRP A 1 301 ? 68.953 44.416 58.317 1.00 0.57 ? 301 TRP A O   1 
ATOM 2283 C CB  . TRP A 1 301 ? 68.863 46.929 56.270 1.00 0.57 ? 301 TRP A CB  1 
ATOM 2284 C CG  . TRP A 1 301 ? 68.332 45.725 55.490 1.00 0.57 ? 301 TRP A CG  1 
ATOM 2285 C CD1 . TRP A 1 301 ? 69.046 44.881 54.683 1.00 0.57 ? 301 TRP A CD1 1 
ATOM 2286 C CD2 . TRP A 1 301 ? 67.016 45.144 55.608 1.00 0.57 ? 301 TRP A CD2 1 
ATOM 2287 N NE1 . TRP A 1 301 ? 68.259 43.824 54.283 1.00 0.57 ? 301 TRP A NE1 1 
ATOM 2288 C CE2 . TRP A 1 301 ? 67.025 43.954 54.856 1.00 0.57 ? 301 TRP A CE2 1 
ATOM 2289 C CE3 . TRP A 1 301 ? 65.876 45.533 56.303 1.00 0.57 ? 301 TRP A CE3 1 
ATOM 2290 C CZ2 . TRP A 1 301 ? 65.912 43.132 54.799 1.00 0.57 ? 301 TRP A CZ2 1 
ATOM 2291 C CZ3 . TRP A 1 301 ? 64.736 44.718 56.219 1.00 0.57 ? 301 TRP A CZ3 1 
ATOM 2292 C CH2 . TRP A 1 301 ? 64.753 43.527 55.483 1.00 0.57 ? 301 TRP A CH2 1 
ATOM 2293 N N   . PRO A 1 302 ? 71.002 45.224 58.270 1.00 0.63 ? 302 PRO A N   1 
ATOM 2294 C CA  . PRO A 1 302 ? 71.604 43.947 58.657 1.00 0.63 ? 302 PRO A CA  1 
ATOM 2295 C C   . PRO A 1 302 ? 71.107 43.386 59.984 1.00 0.63 ? 302 PRO A C   1 
ATOM 2296 O O   . PRO A 1 302 ? 71.160 42.174 60.175 1.00 0.63 ? 302 PRO A O   1 
ATOM 2297 C CB  . PRO A 1 302 ? 73.116 44.235 58.666 1.00 0.63 ? 302 PRO A CB  1 
ATOM 2298 C CG  . PRO A 1 302 ? 73.283 45.374 57.659 1.00 0.63 ? 302 PRO A CG  1 
ATOM 2299 C CD  . PRO A 1 302 ? 72.020 46.204 57.878 1.00 0.63 ? 302 PRO A CD  1 
ATOM 2300 N N   . GLN A 1 303 ? 70.645 44.243 60.916 1.00 0.66 ? 303 GLN A N   1 
ATOM 2301 C CA  . GLN A 1 303 ? 70.000 43.822 62.143 1.00 0.66 ? 303 GLN A CA  1 
ATOM 2302 C C   . GLN A 1 303 ? 68.523 43.492 61.952 1.00 0.66 ? 303 GLN A C   1 
ATOM 2303 O O   . GLN A 1 303 ? 68.045 42.461 62.425 1.00 0.66 ? 303 GLN A O   1 
ATOM 2304 C CB  . GLN A 1 303 ? 70.191 44.874 63.256 1.00 0.66 ? 303 GLN A CB  1 
ATOM 2305 C CG  . GLN A 1 303 ? 71.687 45.142 63.544 1.00 0.66 ? 303 GLN A CG  1 
ATOM 2306 C CD  . GLN A 1 303 ? 71.916 45.513 65.015 1.00 0.66 ? 303 GLN A CD  1 
ATOM 2307 O OE1 . GLN A 1 303 ? 71.464 44.793 65.905 1.00 0.66 ? 303 GLN A OE1 1 
ATOM 2308 N NE2 . GLN A 1 303 ? 72.654 46.616 65.274 1.00 0.66 ? 303 GLN A NE2 1 
ATOM 2309 N N   . ILE A 1 304 ? 67.770 44.328 61.195 1.00 0.63 ? 304 ILE A N   1 
ATOM 2310 C CA  . ILE A 1 304 ? 66.351 44.130 60.885 1.00 0.63 ? 304 ILE A CA  1 
ATOM 2311 C C   . ILE A 1 304 ? 66.102 42.845 60.102 1.00 0.63 ? 304 ILE A C   1 
ATOM 2312 O O   . ILE A 1 304 ? 65.140 42.113 60.339 1.00 0.63 ? 304 ILE A O   1 
ATOM 2313 C CB  . ILE A 1 304 ? 65.760 45.305 60.096 1.00 0.63 ? 304 ILE A CB  1 
ATOM 2314 C CG1 . ILE A 1 304 ? 65.904 46.639 60.865 1.00 0.63 ? 304 ILE A CG1 1 
ATOM 2315 C CG2 . ILE A 1 304 ? 64.266 45.058 59.758 1.00 0.63 ? 304 ILE A CG2 1 
ATOM 2316 C CD1 . ILE A 1 304 ? 65.665 47.873 59.980 1.00 0.63 ? 304 ILE A CD1 1 
ATOM 2317 N N   . ALA A 1 305 ? 67.006 42.523 59.159 1.00 0.63 ? 305 ALA A N   1 
ATOM 2318 C CA  . ALA A 1 305 ? 66.974 41.347 58.318 1.00 0.63 ? 305 ALA A CA  1 
ATOM 2319 C C   . ALA A 1 305 ? 67.010 40.019 59.070 1.00 0.63 ? 305 ALA A C   1 
ATOM 2320 O O   . ALA A 1 305 ? 66.598 38.993 58.542 1.00 0.63 ? 305 ALA A O   1 
ATOM 2321 C CB  . ALA A 1 305 ? 68.161 41.415 57.336 1.00 0.63 ? 305 ALA A CB  1 
ATOM 2322 N N   . GLN A 1 306 ? 67.475 40.013 60.336 1.00 0.59 ? 306 GLN A N   1 
ATOM 2323 C CA  . GLN A 1 306 ? 67.485 38.834 61.179 1.00 0.59 ? 306 GLN A CA  1 
ATOM 2324 C C   . GLN A 1 306 ? 66.101 38.423 61.657 1.00 0.59 ? 306 GLN A C   1 
ATOM 2325 O O   . GLN A 1 306 ? 65.862 37.258 61.958 1.00 0.59 ? 306 GLN A O   1 
ATOM 2326 C CB  . GLN A 1 306 ? 68.369 39.064 62.433 1.00 0.59 ? 306 GLN A CB  1 
ATOM 2327 C CG  . GLN A 1 306 ? 69.801 39.578 62.142 1.00 0.59 ? 306 GLN A CG  1 
ATOM 2328 C CD  . GLN A 1 306 ? 70.553 38.681 61.162 1.00 0.59 ? 306 GLN A CD  1 
ATOM 2329 O OE1 . GLN A 1 306 ? 70.488 37.453 61.205 1.00 0.59 ? 306 GLN A OE1 1 
ATOM 2330 N NE2 . GLN A 1 306 ? 71.317 39.317 60.243 1.00 0.59 ? 306 GLN A NE2 1 
ATOM 2331 N N   . PHE A 1 307 ? 65.140 39.371 61.744 1.00 0.52 ? 307 PHE A N   1 
ATOM 2332 C CA  . PHE A 1 307 ? 63.812 39.126 62.287 1.00 0.52 ? 307 PHE A CA  1 
ATOM 2333 C C   . PHE A 1 307 ? 63.007 38.100 61.498 1.00 0.52 ? 307 PHE A C   1 
ATOM 2334 O O   . PHE A 1 307 ? 62.242 37.319 62.065 1.00 0.52 ? 307 PHE A O   1 
ATOM 2335 C CB  . PHE A 1 307 ? 62.992 40.435 62.435 1.00 0.52 ? 307 PHE A CB  1 
ATOM 2336 C CG  . PHE A 1 307 ? 63.642 41.496 63.292 1.00 0.52 ? 307 PHE A CG  1 
ATOM 2337 C CD1 . PHE A 1 307 ? 64.497 41.203 64.371 1.00 0.52 ? 307 PHE A CD1 1 
ATOM 2338 C CD2 . PHE A 1 307 ? 63.343 42.845 63.029 1.00 0.52 ? 307 PHE A CD2 1 
ATOM 2339 C CE1 . PHE A 1 307 ? 65.051 42.230 65.143 1.00 0.52 ? 307 PHE A CE1 1 
ATOM 2340 C CE2 . PHE A 1 307 ? 63.891 43.875 63.803 1.00 0.52 ? 307 PHE A CE2 1 
ATOM 2341 C CZ  . PHE A 1 307 ? 64.754 43.565 64.857 1.00 0.52 ? 307 PHE A CZ  1 
ATOM 2342 N N   . ALA A 1 308 ? 63.181 38.074 60.164 1.00 0.55 ? 308 ALA A N   1 
ATOM 2343 C CA  . ALA A 1 308 ? 62.667 37.032 59.305 1.00 0.55 ? 308 ALA A CA  1 
ATOM 2344 C C   . ALA A 1 308 ? 63.727 35.932 59.125 1.00 0.55 ? 308 ALA A C   1 
ATOM 2345 O O   . ALA A 1 308 ? 64.833 36.244 58.690 1.00 0.55 ? 308 ALA A O   1 
ATOM 2346 C CB  . ALA A 1 308 ? 62.302 37.627 57.930 1.00 0.55 ? 308 ALA A CB  1 
ATOM 2347 N N   . PRO A 1 309 ? 63.506 34.657 59.433 1.00 0.51 ? 309 PRO A N   1 
ATOM 2348 C CA  . PRO A 1 309 ? 64.506 33.612 59.235 1.00 0.51 ? 309 PRO A CA  1 
ATOM 2349 C C   . PRO A 1 309 ? 64.712 33.228 57.782 1.00 0.51 ? 309 PRO A C   1 
ATOM 2350 O O   . PRO A 1 309 ? 63.794 33.319 56.970 1.00 0.51 ? 309 PRO A O   1 
ATOM 2351 C CB  . PRO A 1 309 ? 63.931 32.402 59.989 1.00 0.51 ? 309 PRO A CB  1 
ATOM 2352 C CG  . PRO A 1 309 ? 62.416 32.618 59.937 1.00 0.51 ? 309 PRO A CG  1 
ATOM 2353 C CD  . PRO A 1 309 ? 62.258 34.136 59.979 1.00 0.51 ? 309 PRO A CD  1 
ATOM 2354 N N   . SER A 1 310 ? 65.921 32.722 57.454 1.00 0.52 ? 310 SER A N   1 
ATOM 2355 C CA  . SER A 1 310 ? 66.173 31.953 56.239 1.00 0.52 ? 310 SER A CA  1 
ATOM 2356 C C   . SER A 1 310 ? 65.421 30.629 56.266 1.00 0.52 ? 310 SER A C   1 
ATOM 2357 O O   . SER A 1 310 ? 65.153 30.076 57.332 1.00 0.52 ? 310 SER A O   1 
ATOM 2358 C CB  . SER A 1 310 ? 67.688 31.687 56.002 1.00 0.52 ? 310 SER A CB  1 
ATOM 2359 O OG  . SER A 1 310 ? 67.950 31.027 54.760 1.00 0.52 ? 310 SER A OG  1 
ATOM 2360 N N   . ALA A 1 311 ? 65.073 30.078 55.087 1.00 0.55 ? 311 ALA A N   1 
ATOM 2361 C CA  . ALA A 1 311 ? 64.247 28.898 54.906 1.00 0.55 ? 311 ALA A CA  1 
ATOM 2362 C C   . ALA A 1 311 ? 64.740 27.633 55.619 1.00 0.55 ? 311 ALA A C   1 
ATOM 2363 O O   . ALA A 1 311 ? 63.944 26.820 56.079 1.00 0.55 ? 311 ALA A O   1 
ATOM 2364 C CB  . ALA A 1 311 ? 64.055 28.636 53.396 1.00 0.55 ? 311 ALA A CB  1 
ATOM 2365 N N   . SER A 1 312 ? 66.072 27.463 55.749 1.00 0.45 ? 312 SER A N   1 
ATOM 2366 C CA  . SER A 1 312 ? 66.714 26.409 56.525 1.00 0.45 ? 312 SER A CA  1 
ATOM 2367 C C   . SER A 1 312 ? 66.432 26.491 58.023 1.00 0.45 ? 312 SER A C   1 
ATOM 2368 O O   . SER A 1 312 ? 66.234 25.478 58.687 1.00 0.45 ? 312 SER A O   1 
ATOM 2369 C CB  . SER A 1 312 ? 68.249 26.396 56.275 1.00 0.45 ? 312 SER A CB  1 
ATOM 2370 O OG  . SER A 1 312 ? 68.839 27.674 56.533 1.00 0.45 ? 312 SER A OG  1 
ATOM 2371 N N   . ALA A 1 313 ? 66.386 27.712 58.597 1.00 0.50 ? 313 ALA A N   1 
ATOM 2372 C CA  . ALA A 1 313 ? 66.145 27.935 60.008 1.00 0.50 ? 313 ALA A CA  1 
ATOM 2373 C C   . ALA A 1 313 ? 64.666 28.119 60.346 1.00 0.50 ? 313 ALA A C   1 
ATOM 2374 O O   . ALA A 1 313 ? 64.265 28.037 61.506 1.00 0.50 ? 313 ALA A O   1 
ATOM 2375 C CB  . ALA A 1 313 ? 66.878 29.229 60.418 1.00 0.50 ? 313 ALA A CB  1 
ATOM 2376 N N   . PHE A 1 314 ? 63.815 28.350 59.327 1.00 0.41 ? 314 PHE A N   1 
ATOM 2377 C CA  . PHE A 1 314 ? 62.422 28.753 59.446 1.00 0.41 ? 314 PHE A CA  1 
ATOM 2378 C C   . PHE A 1 314 ? 61.542 27.791 60.235 1.00 0.41 ? 314 PHE A C   1 
ATOM 2379 O O   . PHE A 1 314 ? 60.784 28.211 61.106 1.00 0.41 ? 314 PHE A O   1 
ATOM 2380 C CB  . PHE A 1 314 ? 61.885 29.000 58.006 1.00 0.41 ? 314 PHE A CB  1 
ATOM 2381 C CG  . PHE A 1 314 ? 60.498 29.581 57.857 1.00 0.41 ? 314 PHE A CG  1 
ATOM 2382 C CD1 . PHE A 1 314 ? 59.855 30.361 58.836 1.00 0.41 ? 314 PHE A CD1 1 
ATOM 2383 C CD2 . PHE A 1 314 ? 59.842 29.379 56.631 1.00 0.41 ? 314 PHE A CD2 1 
ATOM 2384 C CE1 . PHE A 1 314 ? 58.600 30.932 58.587 1.00 0.41 ? 314 PHE A CE1 1 
ATOM 2385 C CE2 . PHE A 1 314 ? 58.579 29.926 56.389 1.00 0.41 ? 314 PHE A CE2 1 
ATOM 2386 C CZ  . PHE A 1 314 ? 57.966 30.717 57.363 1.00 0.41 ? 314 PHE A CZ  1 
ATOM 2387 N N   . PHE A 1 315 ? 61.688 26.471 60.007 1.00 0.36 ? 315 PHE A N   1 
ATOM 2388 C CA  . PHE A 1 315 ? 60.977 25.413 60.710 1.00 0.36 ? 315 PHE A CA  1 
ATOM 2389 C C   . PHE A 1 315 ? 61.306 25.360 62.209 1.00 0.36 ? 315 PHE A C   1 
ATOM 2390 O O   . PHE A 1 315 ? 60.501 24.945 63.038 1.00 0.36 ? 315 PHE A O   1 
ATOM 2391 C CB  . PHE A 1 315 ? 61.282 24.076 59.979 1.00 0.36 ? 315 PHE A CB  1 
ATOM 2392 C CG  . PHE A 1 315 ? 60.452 22.922 60.471 1.00 0.36 ? 315 PHE A CG  1 
ATOM 2393 C CD1 . PHE A 1 315 ? 59.077 22.853 60.194 1.00 0.36 ? 315 PHE A CD1 1 
ATOM 2394 C CD2 . PHE A 1 315 ? 61.050 21.887 61.201 1.00 0.36 ? 315 PHE A CD2 1 
ATOM 2395 C CE1 . PHE A 1 315 ? 58.317 21.762 60.633 1.00 0.36 ? 315 PHE A CE1 1 
ATOM 2396 C CE2 . PHE A 1 315 ? 60.293 20.795 61.646 1.00 0.36 ? 315 PHE A CE2 1 
ATOM 2397 C CZ  . PHE A 1 315 ? 58.925 20.731 61.358 1.00 0.36 ? 315 PHE A CZ  1 
ATOM 2398 N N   . GLY A 1 316 ? 62.510 25.823 62.619 1.00 0.46 ? 316 GLY A N   1 
ATOM 2399 C CA  . GLY A 1 316 ? 62.866 25.920 64.031 1.00 0.46 ? 316 GLY A CA  1 
ATOM 2400 C C   . GLY A 1 316 ? 62.383 27.170 64.723 1.00 0.46 ? 316 GLY A C   1 
ATOM 2401 O O   . GLY A 1 316 ? 62.529 27.299 65.941 1.00 0.46 ? 316 GLY A O   1 
ATOM 2402 N N   . MET A 1 317 ? 61.820 28.124 63.954 1.00 0.39 ? 317 MET A N   1 
ATOM 2403 C CA  . MET A 1 317 ? 61.360 29.405 64.447 1.00 0.39 ? 317 MET A CA  1 
ATOM 2404 C C   . MET A 1 317 ? 59.855 29.585 64.309 1.00 0.39 ? 317 MET A C   1 
ATOM 2405 O O   . MET A 1 317 ? 59.268 30.400 65.012 1.00 0.39 ? 317 MET A O   1 
ATOM 2406 C CB  . MET A 1 317 ? 62.071 30.541 63.665 1.00 0.39 ? 317 MET A CB  1 
ATOM 2407 C CG  . MET A 1 317 ? 63.603 30.563 63.845 1.00 0.39 ? 317 MET A CG  1 
ATOM 2408 S SD  . MET A 1 317 ? 64.114 30.907 65.550 1.00 0.39 ? 317 MET A SD  1 
ATOM 2409 C CE  . MET A 1 317 ? 65.900 30.933 65.254 1.00 0.39 ? 317 MET A CE  1 
ATOM 2410 N N   . SER A 1 318 ? 59.179 28.813 63.442 1.00 0.43 ? 318 SER A N   1 
ATOM 2411 C CA  . SER A 1 318 ? 57.762 28.979 63.197 1.00 0.43 ? 318 SER A CA  1 
ATOM 2412 C C   . SER A 1 318 ? 57.182 27.661 62.736 1.00 0.43 ? 318 SER A C   1 
ATOM 2413 O O   . SER A 1 318 ? 57.869 26.830 62.148 1.00 0.43 ? 318 SER A O   1 
ATOM 2414 C CB  . SER A 1 318 ? 57.527 30.015 62.065 1.00 0.43 ? 318 SER A CB  1 
ATOM 2415 O OG  . SER A 1 318 ? 56.155 30.231 61.721 1.00 0.43 ? 318 SER A OG  1 
ATOM 2416 N N   . ARG A 1 319 ? 55.874 27.442 62.977 1.00 0.36 ? 319 ARG A N   1 
ATOM 2417 C CA  . ARG A 1 319 ? 55.089 26.427 62.298 1.00 0.36 ? 319 ARG A CA  1 
ATOM 2418 C C   . ARG A 1 319 ? 55.034 26.634 60.787 1.00 0.36 ? 319 ARG A C   1 
ATOM 2419 O O   . ARG A 1 319 ? 54.968 27.766 60.314 1.00 0.36 ? 319 ARG A O   1 
ATOM 2420 C CB  . ARG A 1 319 ? 53.633 26.384 62.836 1.00 0.36 ? 319 ARG A CB  1 
ATOM 2421 C CG  . ARG A 1 319 ? 52.838 27.712 62.731 1.00 0.36 ? 319 ARG A CG  1 
ATOM 2422 C CD  . ARG A 1 319 ? 51.398 27.573 63.240 1.00 0.36 ? 319 ARG A CD  1 
ATOM 2423 N NE  . ARG A 1 319 ? 50.730 28.916 63.217 1.00 0.36 ? 319 ARG A NE  1 
ATOM 2424 C CZ  . ARG A 1 319 ? 49.467 29.116 63.627 1.00 0.36 ? 319 ARG A CZ  1 
ATOM 2425 N NH1 . ARG A 1 319 ? 48.954 30.346 63.621 1.00 0.36 ? 319 ARG A NH1 1 
ATOM 2426 N NH2 . ARG A 1 319 ? 48.684 28.114 63.997 1.00 0.36 ? 319 ARG A NH2 1 
ATOM 2427 N N   . ILE A 1 320 ? 55.047 25.544 59.989 1.00 0.42 ? 320 ILE A N   1 
ATOM 2428 C CA  . ILE A 1 320 ? 55.023 25.638 58.536 1.00 0.42 ? 320 ILE A CA  1 
ATOM 2429 C C   . ILE A 1 320 ? 53.942 24.702 58.026 1.00 0.42 ? 320 ILE A C   1 
ATOM 2430 O O   . ILE A 1 320 ? 53.814 23.565 58.479 1.00 0.42 ? 320 ILE A O   1 
ATOM 2431 C CB  . ILE A 1 320 ? 56.386 25.328 57.901 1.00 0.42 ? 320 ILE A CB  1 
ATOM 2432 C CG1 . ILE A 1 320 ? 57.423 26.401 58.331 1.00 0.42 ? 320 ILE A CG1 1 
ATOM 2433 C CG2 . ILE A 1 320 ? 56.274 25.251 56.358 1.00 0.42 ? 320 ILE A CG2 1 
ATOM 2434 C CD1 . ILE A 1 320 ? 58.824 26.215 57.739 1.00 0.42 ? 320 ILE A CD1 1 
ATOM 2435 N N   . GLY A 1 321 ? 53.111 25.175 57.075 1.00 0.53 ? 321 GLY A N   1 
ATOM 2436 C CA  . GLY A 1 321 ? 52.102 24.361 56.415 1.00 0.53 ? 321 GLY A CA  1 
ATOM 2437 C C   . GLY A 1 321 ? 51.477 25.185 55.325 1.00 0.53 ? 321 GLY A C   1 
ATOM 2438 O O   . GLY A 1 321 ? 52.062 26.186 54.916 1.00 0.53 ? 321 GLY A O   1 
ATOM 2439 N N   . MET A 1 322 ? 50.276 24.813 54.838 1.00 0.43 ? 322 MET A N   1 
ATOM 2440 C CA  . MET A 1 322 ? 49.529 25.631 53.895 1.00 0.43 ? 322 MET A CA  1 
ATOM 2441 C C   . MET A 1 322 ? 48.035 25.595 54.183 1.00 0.43 ? 322 MET A C   1 
ATOM 2442 O O   . MET A 1 322 ? 47.529 24.656 54.796 1.00 0.43 ? 322 MET A O   1 
ATOM 2443 C CB  . MET A 1 322 ? 49.720 25.199 52.414 1.00 0.43 ? 322 MET A CB  1 
ATOM 2444 C CG  . MET A 1 322 ? 51.112 25.528 51.847 1.00 0.43 ? 322 MET A CG  1 
ATOM 2445 S SD  . MET A 1 322 ? 51.162 25.693 50.036 1.00 0.43 ? 322 MET A SD  1 
ATOM 2446 C CE  . MET A 1 322 ? 50.864 23.945 49.661 1.00 0.43 ? 322 MET A CE  1 
ATOM 2447 N N   . GLU A 1 323 ? 47.308 26.623 53.696 1.00 0.48 ? 323 GLU A N   1 
ATOM 2448 C CA  . GLU A 1 323 ? 45.873 26.769 53.819 1.00 0.48 ? 323 GLU A CA  1 
ATOM 2449 C C   . GLU A 1 323 ? 45.269 27.229 52.490 1.00 0.48 ? 323 GLU A C   1 
ATOM 2450 O O   . GLU A 1 323 ? 45.933 27.836 51.649 1.00 0.48 ? 323 GLU A O   1 
ATOM 2451 C CB  . GLU A 1 323 ? 45.531 27.766 54.958 1.00 0.48 ? 323 GLU A CB  1 
ATOM 2452 C CG  . GLU A 1 323 ? 46.027 29.222 54.760 1.00 0.48 ? 323 GLU A CG  1 
ATOM 2453 C CD  . GLU A 1 323 ? 45.994 30.002 56.078 1.00 0.48 ? 323 GLU A CD  1 
ATOM 2454 O OE1 . GLU A 1 323 ? 46.726 29.595 57.026 1.00 0.48 ? 323 GLU A OE1 1 
ATOM 2455 O OE2 . GLU A 1 323 ? 45.222 30.993 56.148 1.00 0.48 ? 323 GLU A OE2 1 
ATOM 2456 N N   . VAL A 1 324 ? 43.989 26.873 52.216 1.00 0.44 ? 324 VAL A N   1 
ATOM 2457 C CA  . VAL A 1 324 ? 43.251 27.281 51.020 1.00 0.44 ? 324 VAL A CA  1 
ATOM 2458 C C   . VAL A 1 324 ? 42.875 28.771 50.987 1.00 0.44 ? 324 VAL A C   1 
ATOM 2459 O O   . VAL A 1 324 ? 42.464 29.341 51.993 1.00 0.44 ? 324 VAL A O   1 
ATOM 2460 C CB  . VAL A 1 324 ? 42.000 26.422 50.778 1.00 0.44 ? 324 VAL A CB  1 
ATOM 2461 C CG1 . VAL A 1 324 ? 42.414 24.976 50.425 1.00 0.44 ? 324 VAL A CG1 1 
ATOM 2462 C CG2 . VAL A 1 324 ? 41.045 26.434 51.994 1.00 0.44 ? 324 VAL A CG2 1 
ATOM 2463 N N   . THR A 1 325 ? 42.978 29.448 49.816 1.00 0.48 ? 325 THR A N   1 
ATOM 2464 C CA  . THR A 1 325 ? 42.600 30.852 49.680 1.00 0.48 ? 325 THR A CA  1 
ATOM 2465 C C   . THR A 1 325 ? 41.910 31.066 48.338 1.00 0.48 ? 325 THR A C   1 
ATOM 2466 O O   . THR A 1 325 ? 41.914 30.161 47.496 1.00 0.48 ? 325 THR A O   1 
ATOM 2467 C CB  . THR A 1 325 ? 43.705 31.917 49.871 1.00 0.48 ? 325 THR A CB  1 
ATOM 2468 O OG1 . THR A 1 325 ? 44.632 32.051 48.808 1.00 0.48 ? 325 THR A OG1 1 
ATOM 2469 C CG2 . THR A 1 325 ? 44.506 31.725 51.166 1.00 0.48 ? 325 THR A CG2 1 
ATOM 2470 N N   . PRO A 1 326 ? 41.302 32.231 48.058 1.00 0.44 ? 326 PRO A N   1 
ATOM 2471 C CA  . PRO A 1 326 ? 40.830 32.609 46.731 1.00 0.44 ? 326 PRO A CA  1 
ATOM 2472 C C   . PRO A 1 326 ? 41.905 32.763 45.676 1.00 0.44 ? 326 PRO A C   1 
ATOM 2473 O O   . PRO A 1 326 ? 41.556 33.165 44.570 1.00 0.44 ? 326 PRO A O   1 
ATOM 2474 C CB  . PRO A 1 326 ? 40.146 33.967 46.935 1.00 0.44 ? 326 PRO A CB  1 
ATOM 2475 C CG  . PRO A 1 326 ? 39.668 33.927 48.382 1.00 0.44 ? 326 PRO A CG  1 
ATOM 2476 C CD  . PRO A 1 326 ? 40.771 33.139 49.079 1.00 0.44 ? 326 PRO A CD  1 
ATOM 2477 N N   . SER A 1 327 ? 43.190 32.543 46.018 1.00 0.47 ? 327 SER A N   1 
ATOM 2478 C CA  . SER A 1 327 ? 44.311 32.563 45.100 1.00 0.47 ? 327 SER A CA  1 
ATOM 2479 C C   . SER A 1 327 ? 44.976 31.197 45.050 1.00 0.47 ? 327 SER A C   1 
ATOM 2480 O O   . SER A 1 327 ? 46.114 31.076 44.609 1.00 0.47 ? 327 SER A O   1 
ATOM 2481 C CB  . SER A 1 327 ? 45.406 33.591 45.477 1.00 0.47 ? 327 SER A CB  1 
ATOM 2482 O OG  . SER A 1 327 ? 44.876 34.919 45.551 1.00 0.47 ? 327 SER A OG  1 
ATOM 2483 N N   . GLY A 1 328 ? 44.286 30.120 45.503 1.00 0.46 ? 328 GLY A N   1 
ATOM 2484 C CA  . GLY A 1 328 ? 44.862 28.780 45.634 1.00 0.46 ? 328 GLY A CA  1 
ATOM 2485 C C   . GLY A 1 328 ? 45.519 28.558 46.978 1.00 0.46 ? 328 GLY A C   1 
ATOM 2486 O O   . GLY A 1 328 ? 45.454 29.396 47.868 1.00 0.46 ? 328 GLY A O   1 
ATOM 2487 N N   . THR A 1 329 ? 46.130 27.379 47.226 1.00 0.46 ? 329 THR A N   1 
ATOM 2488 C CA  . THR A 1 329 ? 46.827 27.105 48.480 1.00 0.46 ? 329 THR A CA  1 
ATOM 2489 C C   . THR A 1 329 ? 48.071 27.965 48.710 1.00 0.46 ? 329 THR A C   1 
ATOM 2490 O O   . THR A 1 329 ? 48.903 28.118 47.818 1.00 0.46 ? 329 THR A O   1 
ATOM 2491 C CB  . THR A 1 329 ? 47.205 25.630 48.649 1.00 0.46 ? 329 THR A CB  1 
ATOM 2492 O OG1 . THR A 1 329 ? 47.804 25.064 47.488 1.00 0.46 ? 329 THR A OG1 1 
ATOM 2493 C CG2 . THR A 1 329 ? 45.943 24.790 48.882 1.00 0.46 ? 329 THR A CG2 1 
ATOM 2494 N N   . TRP A 1 330 ? 48.254 28.523 49.930 1.00 0.40 ? 330 TRP A N   1 
ATOM 2495 C CA  . TRP A 1 330 ? 49.471 29.254 50.258 1.00 0.40 ? 330 TRP A CA  1 
ATOM 2496 C C   . TRP A 1 330 ? 49.892 29.012 51.705 1.00 0.40 ? 330 TRP A C   1 
ATOM 2497 O O   . TRP A 1 330 ? 49.153 28.426 52.486 1.00 0.40 ? 330 TRP A O   1 
ATOM 2498 C CB  . TRP A 1 330 ? 49.383 30.777 49.945 1.00 0.40 ? 330 TRP A CB  1 
ATOM 2499 C CG  . TRP A 1 330 ? 50.733 31.497 49.922 1.00 0.40 ? 330 TRP A CG  1 
ATOM 2500 C CD1 . TRP A 1 330 ? 51.771 31.253 49.071 1.00 0.40 ? 330 TRP A CD1 1 
ATOM 2501 C CD2 . TRP A 1 330 ? 51.239 32.410 50.920 1.00 0.40 ? 330 TRP A CD2 1 
ATOM 2502 N NE1 . TRP A 1 330 ? 52.885 31.969 49.456 1.00 0.40 ? 330 TRP A NE1 1 
ATOM 2503 C CE2 . TRP A 1 330 ? 52.588 32.662 50.601 1.00 0.40 ? 330 TRP A CE2 1 
ATOM 2504 C CE3 . TRP A 1 330 ? 50.664 32.962 52.058 1.00 0.40 ? 330 TRP A CE3 1 
ATOM 2505 C CZ2 . TRP A 1 330 ? 53.383 33.455 51.420 1.00 0.40 ? 330 TRP A CZ2 1 
ATOM 2506 C CZ3 . TRP A 1 330 ? 51.466 33.761 52.884 1.00 0.40 ? 330 TRP A CZ3 1 
ATOM 2507 C CH2 . TRP A 1 330 ? 52.813 33.999 52.576 1.00 0.40 ? 330 TRP A CH2 1 
ATOM 2508 N N   . LEU A 1 331 ? 51.140 29.418 52.036 1.00 0.49 ? 331 LEU A N   1 
ATOM 2509 C CA  . LEU A 1 331 ? 51.863 29.265 53.288 1.00 0.49 ? 331 LEU A CA  1 
ATOM 2510 C C   . LEU A 1 331 ? 51.163 29.707 54.566 1.00 0.49 ? 331 LEU A C   1 
ATOM 2511 O O   . LEU A 1 331 ? 50.702 30.838 54.704 1.00 0.49 ? 331 LEU A O   1 
ATOM 2512 C CB  . LEU A 1 331 ? 53.189 30.069 53.184 1.00 0.49 ? 331 LEU A CB  1 
ATOM 2513 C CG  . LEU A 1 331 ? 54.146 30.037 54.400 1.00 0.49 ? 331 LEU A CG  1 
ATOM 2514 C CD1 . LEU A 1 331 ? 54.764 28.650 54.638 1.00 0.49 ? 331 LEU A CD1 1 
ATOM 2515 C CD2 . LEU A 1 331 ? 55.242 31.104 54.241 1.00 0.49 ? 331 LEU A CD2 1 
ATOM 2516 N N   . THR A 1 332 ? 51.188 28.809 55.568 1.00 0.53 ? 332 THR A N   1 
ATOM 2517 C CA  . THR A 1 332 ? 50.718 29.033 56.925 1.00 0.53 ? 332 THR A CA  1 
ATOM 2518 C C   . THR A 1 332 ? 51.935 29.212 57.810 1.00 0.53 ? 332 THR A C   1 
ATOM 2519 O O   . THR A 1 332 ? 52.751 28.298 57.919 1.00 0.53 ? 332 THR A O   1 
ATOM 2520 C CB  . THR A 1 332 ? 49.985 27.821 57.495 1.00 0.53 ? 332 THR A CB  1 
ATOM 2521 O OG1 . THR A 1 332 ? 48.986 27.342 56.619 1.00 0.53 ? 332 THR A OG1 1 
ATOM 2522 C CG2 . THR A 1 332 ? 49.331 28.153 58.847 1.00 0.53 ? 332 THR A CG2 1 
ATOM 2523 N N   . TYR A 1 333 ? 52.108 30.375 58.478 1.00 0.40 ? 333 TYR A N   1 
ATOM 2524 C CA  . TYR A 1 333 ? 53.281 30.625 59.307 1.00 0.40 ? 333 TYR A CA  1 
ATOM 2525 C C   . TYR A 1 333 ? 52.989 31.720 60.338 1.00 0.40 ? 333 TYR A C   1 
ATOM 2526 O O   . TYR A 1 333 ? 52.054 32.498 60.156 1.00 0.40 ? 333 TYR A O   1 
ATOM 2527 C CB  . TYR A 1 333 ? 54.540 30.980 58.453 1.00 0.40 ? 333 TYR A CB  1 
ATOM 2528 C CG  . TYR A 1 333 ? 54.602 32.423 58.006 1.00 0.40 ? 333 TYR A CG  1 
ATOM 2529 C CD1 . TYR A 1 333 ? 53.752 32.924 57.006 1.00 0.40 ? 333 TYR A CD1 1 
ATOM 2530 C CD2 . TYR A 1 333 ? 55.482 33.311 58.651 1.00 0.40 ? 333 TYR A CD2 1 
ATOM 2531 C CE1 . TYR A 1 333 ? 53.822 34.271 56.624 1.00 0.40 ? 333 TYR A CE1 1 
ATOM 2532 C CE2 . TYR A 1 333 ? 55.546 34.656 58.277 1.00 0.40 ? 333 TYR A CE2 1 
ATOM 2533 C CZ  . TYR A 1 333 ? 54.747 35.123 57.235 1.00 0.40 ? 333 TYR A CZ  1 
ATOM 2534 O OH  . TYR A 1 333 ? 54.925 36.437 56.773 1.00 0.40 ? 333 TYR A OH  1 
ATOM 2535 N N   . THR A 1 334 ? 53.763 31.818 61.446 1.00 0.44 ? 334 THR A N   1 
ATOM 2536 C CA  . THR A 1 334 ? 53.526 32.849 62.458 1.00 0.44 ? 334 THR A CA  1 
ATOM 2537 C C   . THR A 1 334 ? 54.806 33.289 63.162 1.00 0.44 ? 334 THR A C   1 
ATOM 2538 O O   . THR A 1 334 ? 55.521 32.457 63.703 1.00 0.44 ? 334 THR A O   1 
ATOM 2539 C CB  . THR A 1 334 ? 52.660 32.333 63.609 1.00 0.44 ? 334 THR A CB  1 
ATOM 2540 O OG1 . THR A 1 334 ? 51.436 31.749 63.208 1.00 0.44 ? 334 THR A OG1 1 
ATOM 2541 C CG2 . THR A 1 334 ? 52.189 33.462 64.528 1.00 0.44 ? 334 THR A CG2 1 
ATOM 2542 N N   . GLY A 1 335 ? 55.078 34.616 63.279 1.00 0.48 ? 335 GLY A N   1 
ATOM 2543 C CA  . GLY A 1 335 ? 56.106 35.150 64.190 1.00 0.48 ? 335 GLY A CA  1 
ATOM 2544 C C   . GLY A 1 335 ? 57.512 35.349 63.654 1.00 0.48 ? 335 GLY A C   1 
ATOM 2545 O O   . GLY A 1 335 ? 57.923 34.784 62.644 1.00 0.48 ? 335 GLY A O   1 
ATOM 2546 N N   . ALA A 1 336 ? 58.277 36.228 64.344 1.00 0.50 ? 336 ALA A N   1 
ATOM 2547 C CA  . ALA A 1 336 ? 59.688 36.490 64.116 1.00 0.50 ? 336 ALA A CA  1 
ATOM 2548 C C   . ALA A 1 336 ? 60.589 35.444 64.774 1.00 0.50 ? 336 ALA A C   1 
ATOM 2549 O O   . ALA A 1 336 ? 60.130 34.578 65.514 1.00 0.50 ? 336 ALA A O   1 
ATOM 2550 C CB  . ALA A 1 336 ? 60.054 37.889 64.676 1.00 0.50 ? 336 ALA A CB  1 
ATOM 2551 N N   . ILE A 1 337 ? 61.914 35.493 64.508 1.00 0.45 ? 337 ILE A N   1 
ATOM 2552 C CA  . ILE A 1 337 ? 62.899 34.634 65.160 1.00 0.45 ? 337 ILE A CA  1 
ATOM 2553 C C   . ILE A 1 337 ? 62.987 34.735 66.683 1.00 0.45 ? 337 ILE A C   1 
ATOM 2554 O O   . ILE A 1 337 ? 62.732 35.764 67.306 1.00 0.45 ? 337 ILE A O   1 
ATOM 2555 C CB  . ILE A 1 337 ? 64.320 34.759 64.605 1.00 0.45 ? 337 ILE A CB  1 
ATOM 2556 C CG1 . ILE A 1 337 ? 65.010 36.100 64.954 1.00 0.45 ? 337 ILE A CG1 1 
ATOM 2557 C CG2 . ILE A 1 337 ? 64.298 34.505 63.083 1.00 0.45 ? 337 ILE A CG2 1 
ATOM 2558 C CD1 . ILE A 1 337 ? 66.536 36.030 64.821 1.00 0.45 ? 337 ILE A CD1 1 
ATOM 2559 N N   . LYS A 1 338 ? 63.381 33.622 67.331 1.00 0.43 ? 338 LYS A N   1 
ATOM 2560 C CA  . LYS A 1 338 ? 63.758 33.575 68.731 1.00 0.43 ? 338 LYS A CA  1 
ATOM 2561 C C   . LYS A 1 338 ? 65.077 34.295 69.022 1.00 0.43 ? 338 LYS A C   1 
ATOM 2562 O O   . LYS A 1 338 ? 65.969 34.331 68.178 1.00 0.43 ? 338 LYS A O   1 
ATOM 2563 C CB  . LYS A 1 338 ? 63.879 32.106 69.200 1.00 0.43 ? 338 LYS A CB  1 
ATOM 2564 C CG  . LYS A 1 338 ? 62.557 31.329 69.074 1.00 0.43 ? 338 LYS A CG  1 
ATOM 2565 C CD  . LYS A 1 338 ? 62.662 29.852 69.502 1.00 0.43 ? 338 LYS A CD  1 
ATOM 2566 C CE  . LYS A 1 338 ? 63.519 29.012 68.550 1.00 0.43 ? 338 LYS A CE  1 
ATOM 2567 N NZ  . LYS A 1 338 ? 63.495 27.583 68.925 1.00 0.43 ? 338 LYS A NZ  1 
ATOM 2568 N N   . LEU A 1 339 ? 65.243 34.855 70.239 1.00 0.42 ? 339 LEU A N   1 
ATOM 2569 C CA  . LEU A 1 339 ? 66.438 35.584 70.630 1.00 0.42 ? 339 LEU A CA  1 
ATOM 2570 C C   . LEU A 1 339 ? 66.846 35.167 72.038 1.00 0.42 ? 339 LEU A C   1 
ATOM 2571 O O   . LEU A 1 339 ? 66.035 34.602 72.768 1.00 0.42 ? 339 LEU A O   1 
ATOM 2572 C CB  . LEU A 1 339 ? 66.187 37.117 70.620 1.00 0.42 ? 339 LEU A CB  1 
ATOM 2573 C CG  . LEU A 1 339 ? 66.031 37.754 69.222 1.00 0.42 ? 339 LEU A CG  1 
ATOM 2574 C CD1 . LEU A 1 339 ? 65.635 39.234 69.345 1.00 0.42 ? 339 LEU A CD1 1 
ATOM 2575 C CD2 . LEU A 1 339 ? 67.313 37.622 68.383 1.00 0.42 ? 339 LEU A CD2 1 
ATOM 2576 N N   . ASP A 1 340 ? 68.111 35.444 72.425 1.00 0.42 ? 340 ASP A N   1 
ATOM 2577 C CA  . ASP A 1 340 ? 68.669 35.185 73.739 1.00 0.42 ? 340 ASP A CA  1 
ATOM 2578 C C   . ASP A 1 340 ? 69.068 36.541 74.324 1.00 0.42 ? 340 ASP A C   1 
ATOM 2579 O O   . ASP A 1 340 ? 69.755 37.326 73.670 1.00 0.42 ? 340 ASP A O   1 
ATOM 2580 C CB  . ASP A 1 340 ? 69.905 34.237 73.591 1.00 0.42 ? 340 ASP A CB  1 
ATOM 2581 C CG  . ASP A 1 340 ? 70.635 33.870 74.883 1.00 0.42 ? 340 ASP A CG  1 
ATOM 2582 O OD1 . ASP A 1 340 ? 70.296 34.410 75.968 1.00 0.42 ? 340 ASP A OD1 1 
ATOM 2583 O OD2 . ASP A 1 340 ? 71.589 33.056 74.785 1.00 0.42 ? 340 ASP A OD2 1 
ATOM 2584 N N   . ASP A 1 341 ? 68.659 36.836 75.578 1.00 0.46 ? 341 ASP A N   1 
ATOM 2585 C CA  . ASP A 1 341 ? 69.006 38.015 76.347 1.00 0.46 ? 341 ASP A CA  1 
ATOM 2586 C C   . ASP A 1 341 ? 70.509 38.170 76.597 1.00 0.46 ? 341 ASP A C   1 
ATOM 2587 O O   . ASP A 1 341 ? 71.001 39.264 76.871 1.00 0.46 ? 341 ASP A O   1 
ATOM 2588 C CB  . ASP A 1 341 ? 68.307 38.015 77.739 1.00 0.46 ? 341 ASP A CB  1 
ATOM 2589 C CG  . ASP A 1 341 ? 66.808 37.748 77.679 1.00 0.46 ? 341 ASP A CG  1 
ATOM 2590 O OD1 . ASP A 1 341 ? 66.430 36.647 77.207 1.00 0.46 ? 341 ASP A OD1 1 
ATOM 2591 O OD2 . ASP A 1 341 ? 66.049 38.606 78.196 1.00 0.46 ? 341 ASP A OD2 1 
ATOM 2592 N N   . LYS A 1 342 ? 71.278 37.063 76.538 1.00 0.47 ? 342 LYS A N   1 
ATOM 2593 C CA  . LYS A 1 342 ? 72.709 37.073 76.784 1.00 0.47 ? 342 LYS A CA  1 
ATOM 2594 C C   . LYS A 1 342 ? 73.524 37.374 75.529 1.00 0.47 ? 342 LYS A C   1 
ATOM 2595 O O   . LYS A 1 342 ? 74.728 37.613 75.623 1.00 0.47 ? 342 LYS A O   1 
ATOM 2596 C CB  . LYS A 1 342 ? 73.180 35.716 77.375 1.00 0.47 ? 342 LYS A CB  1 
ATOM 2597 C CG  . LYS A 1 342 ? 73.018 35.569 78.901 1.00 0.47 ? 342 LYS A CG  1 
ATOM 2598 C CD  . LYS A 1 342 ? 71.567 35.570 79.405 1.00 0.47 ? 342 LYS A CD  1 
ATOM 2599 C CE  . LYS A 1 342 ? 71.476 35.230 80.894 1.00 0.47 ? 342 LYS A CE  1 
ATOM 2600 N NZ  . LYS A 1 342 ? 70.067 35.239 81.334 1.00 0.47 ? 342 LYS A NZ  1 
ATOM 2601 N N   . ASP A 1 343 ? 72.907 37.399 74.326 1.00 0.53 ? 343 ASP A N   1 
ATOM 2602 C CA  . ASP A 1 343 ? 73.570 37.789 73.092 1.00 0.53 ? 343 ASP A CA  1 
ATOM 2603 C C   . ASP A 1 343 ? 74.016 39.269 73.142 1.00 0.53 ? 343 ASP A C   1 
ATOM 2604 O O   . ASP A 1 343 ? 73.193 40.126 73.472 1.00 0.53 ? 343 ASP A O   1 
ATOM 2605 C CB  . ASP A 1 343 ? 72.604 37.469 71.907 1.00 0.53 ? 343 ASP A CB  1 
ATOM 2606 C CG  . ASP A 1 343 ? 73.097 37.766 70.498 1.00 0.53 ? 343 ASP A CG  1 
ATOM 2607 O OD1 . ASP A 1 343 ? 74.128 38.468 70.334 1.00 0.53 ? 343 ASP A OD1 1 
ATOM 2608 O OD2 . ASP A 1 343 ? 72.401 37.347 69.544 1.00 0.53 ? 343 ASP A OD2 1 
ATOM 2609 N N   . PRO A 1 344 ? 75.251 39.683 72.821 1.00 0.54 ? 344 PRO A N   1 
ATOM 2610 C CA  . PRO A 1 344 ? 75.650 41.089 72.764 1.00 0.54 ? 344 PRO A CA  1 
ATOM 2611 C C   . PRO A 1 344 ? 74.846 41.918 71.767 1.00 0.54 ? 344 PRO A C   1 
ATOM 2612 O O   . PRO A 1 344 ? 74.755 43.135 71.939 1.00 0.54 ? 344 PRO A O   1 
ATOM 2613 C CB  . PRO A 1 344 ? 77.156 41.048 72.453 1.00 0.54 ? 344 PRO A CB  1 
ATOM 2614 C CG  . PRO A 1 344 ? 77.373 39.685 71.790 1.00 0.54 ? 344 PRO A CG  1 
ATOM 2615 C CD  . PRO A 1 344 ? 76.365 38.790 72.502 1.00 0.54 ? 344 PRO A CD  1 
ATOM 2616 N N   . ASN A 1 345 ? 74.246 41.292 70.731 1.00 0.60 ? 345 ASN A N   1 
ATOM 2617 C CA  . ASN A 1 345 ? 73.413 41.961 69.750 1.00 0.60 ? 345 ASN A CA  1 
ATOM 2618 C C   . ASN A 1 345 ? 72.019 42.279 70.299 1.00 0.60 ? 345 ASN A C   1 
ATOM 2619 O O   . ASN A 1 345 ? 71.317 43.152 69.794 1.00 0.60 ? 345 ASN A O   1 
ATOM 2620 C CB  . ASN A 1 345 ? 73.238 41.095 68.478 1.00 0.60 ? 345 ASN A CB  1 
ATOM 2621 C CG  . ASN A 1 345 ? 74.583 40.823 67.813 1.00 0.60 ? 345 ASN A CG  1 
ATOM 2622 O OD1 . ASN A 1 345 ? 75.067 41.612 67.000 1.00 0.60 ? 345 ASN A OD1 1 
ATOM 2623 N ND2 . ASN A 1 345 ? 75.205 39.669 68.138 1.00 0.60 ? 345 ASN A ND2 1 
ATOM 2624 N N   . PHE A 1 346 ? 71.590 41.600 71.392 1.00 0.51 ? 346 PHE A N   1 
ATOM 2625 C CA  . PHE A 1 346 ? 70.287 41.772 72.021 1.00 0.51 ? 346 PHE A CA  1 
ATOM 2626 C C   . PHE A 1 346 ? 70.067 43.184 72.539 1.00 0.51 ? 346 PHE A C   1 
ATOM 2627 O O   . PHE A 1 346 ? 68.972 43.721 72.444 1.00 0.51 ? 346 PHE A O   1 
ATOM 2628 C CB  . PHE A 1 346 ? 70.062 40.728 73.145 1.00 0.51 ? 346 PHE A CB  1 
ATOM 2629 C CG  . PHE A 1 346 ? 68.662 40.753 73.701 1.00 0.51 ? 346 PHE A CG  1 
ATOM 2630 C CD1 . PHE A 1 346 ? 67.611 40.119 73.023 1.00 0.51 ? 346 PHE A CD1 1 
ATOM 2631 C CD2 . PHE A 1 346 ? 68.396 41.383 74.928 1.00 0.51 ? 346 PHE A CD2 1 
ATOM 2632 C CE1 . PHE A 1 346 ? 66.323 40.088 73.571 1.00 0.51 ? 346 PHE A CE1 1 
ATOM 2633 C CE2 . PHE A 1 346 ? 67.111 41.353 75.481 1.00 0.51 ? 346 PHE A CE2 1 
ATOM 2634 C CZ  . PHE A 1 346 ? 66.074 40.697 74.805 1.00 0.51 ? 346 PHE A CZ  1 
ATOM 2635 N N   . LYS A 1 347 ? 71.138 43.833 73.034 1.00 0.51 ? 347 LYS A N   1 
ATOM 2636 C CA  . LYS A 1 347 ? 71.154 45.214 73.484 1.00 0.51 ? 347 LYS A CA  1 
ATOM 2637 C C   . LYS A 1 347 ? 70.639 46.199 72.433 1.00 0.51 ? 347 LYS A C   1 
ATOM 2638 O O   . LYS A 1 347 ? 69.937 47.153 72.761 1.00 0.51 ? 347 LYS A O   1 
ATOM 2639 C CB  . LYS A 1 347 ? 72.605 45.543 73.933 1.00 0.51 ? 347 LYS A CB  1 
ATOM 2640 C CG  . LYS A 1 347 ? 72.885 46.975 74.437 1.00 0.51 ? 347 LYS A CG  1 
ATOM 2641 C CD  . LYS A 1 347 ? 73.313 47.990 73.353 1.00 0.51 ? 347 LYS A CD  1 
ATOM 2642 C CE  . LYS A 1 347 ? 74.642 47.658 72.659 1.00 0.51 ? 347 LYS A CE  1 
ATOM 2643 N NZ  . LYS A 1 347 ? 74.850 48.553 71.505 1.00 0.51 ? 347 LYS A NZ  1 
ATOM 2644 N N   . ASP A 1 348 ? 70.957 45.982 71.139 1.00 0.55 ? 348 ASP A N   1 
ATOM 2645 C CA  . ASP A 1 348 ? 70.368 46.742 70.055 1.00 0.55 ? 348 ASP A CA  1 
ATOM 2646 C C   . ASP A 1 348 ? 68.987 46.194 69.682 1.00 0.55 ? 348 ASP A C   1 
ATOM 2647 O O   . ASP A 1 348 ? 68.005 46.931 69.598 1.00 0.55 ? 348 ASP A O   1 
ATOM 2648 C CB  . ASP A 1 348 ? 71.274 46.685 68.795 1.00 0.55 ? 348 ASP A CB  1 
ATOM 2649 C CG  . ASP A 1 348 ? 72.580 47.445 68.934 1.00 0.55 ? 348 ASP A CG  1 
ATOM 2650 O OD1 . ASP A 1 348 ? 72.835 48.032 70.016 1.00 0.55 ? 348 ASP A OD1 1 
ATOM 2651 O OD2 . ASP A 1 348 ? 73.361 47.470 67.947 1.00 0.55 ? 348 ASP A OD2 1 
ATOM 2652 N N   . GLN A 1 349 ? 68.859 44.862 69.487 1.00 0.64 ? 349 GLN A N   1 
ATOM 2653 C CA  . GLN A 1 349 ? 67.647 44.231 68.977 1.00 0.64 ? 349 GLN A CA  1 
ATOM 2654 C C   . GLN A 1 349 ? 66.410 44.418 69.830 1.00 0.64 ? 349 GLN A C   1 
ATOM 2655 O O   . GLN A 1 349 ? 65.316 44.591 69.299 1.00 0.64 ? 349 GLN A O   1 
ATOM 2656 C CB  . GLN A 1 349 ? 67.831 42.719 68.672 1.00 0.64 ? 349 GLN A CB  1 
ATOM 2657 C CG  . GLN A 1 349 ? 68.881 42.415 67.573 1.00 0.64 ? 349 GLN A CG  1 
ATOM 2658 C CD  . GLN A 1 349 ? 68.403 42.766 66.158 1.00 0.64 ? 349 GLN A CD  1 
ATOM 2659 O OE1 . GLN A 1 349 ? 67.842 43.824 65.883 1.00 0.64 ? 349 GLN A OE1 1 
ATOM 2660 N NE2 . GLN A 1 349 ? 68.619 41.830 65.207 1.00 0.64 ? 349 GLN A NE2 1 
ATOM 2661 N N   . VAL A 1 350 ? 66.551 44.436 71.166 1.00 0.57 ? 350 VAL A N   1 
ATOM 2662 C CA  . VAL A 1 350 ? 65.465 44.638 72.106 1.00 0.57 ? 350 VAL A CA  1 
ATOM 2663 C C   . VAL A 1 350 ? 64.742 45.983 71.939 1.00 0.57 ? 350 VAL A C   1 
ATOM 2664 O O   . VAL A 1 350 ? 63.552 46.065 72.213 1.00 0.57 ? 350 VAL A O   1 
ATOM 2665 C CB  . VAL A 1 350 ? 65.923 44.328 73.533 1.00 0.57 ? 350 VAL A CB  1 
ATOM 2666 C CG1 . VAL A 1 350 ? 66.771 45.460 74.146 1.00 0.57 ? 350 VAL A CG1 1 
ATOM 2667 C CG2 . VAL A 1 350 ? 64.721 43.953 74.425 1.00 0.57 ? 350 VAL A CG2 1 
ATOM 2668 N N   . ILE A 1 351 ? 65.419 47.034 71.396 1.00 0.58 ? 351 ILE A N   1 
ATOM 2669 C CA  . ILE A 1 351 ? 64.776 48.299 71.050 1.00 0.58 ? 351 ILE A CA  1 
ATOM 2670 C C   . ILE A 1 351 ? 64.583 48.479 69.542 1.00 0.58 ? 351 ILE A C   1 
ATOM 2671 O O   . ILE A 1 351 ? 63.672 49.178 69.092 1.00 0.58 ? 351 ILE A O   1 
ATOM 2672 C CB  . ILE A 1 351 ? 65.535 49.520 71.573 1.00 0.58 ? 351 ILE A CB  1 
ATOM 2673 C CG1 . ILE A 1 351 ? 67.034 49.544 71.177 1.00 0.58 ? 351 ILE A CG1 1 
ATOM 2674 C CG2 . ILE A 1 351 ? 65.335 49.548 73.104 1.00 0.58 ? 351 ILE A CG2 1 
ATOM 2675 C CD1 . ILE A 1 351 ? 67.750 50.847 71.543 1.00 0.58 ? 351 ILE A CD1 1 
ATOM 2676 N N   . LEU A 1 352 ? 65.419 47.837 68.692 1.00 0.63 ? 352 LEU A N   1 
ATOM 2677 C CA  . LEU A 1 352 ? 65.275 47.823 67.241 1.00 0.63 ? 352 LEU A CA  1 
ATOM 2678 C C   . LEU A 1 352 ? 64.010 47.098 66.789 1.00 0.63 ? 352 LEU A C   1 
ATOM 2679 O O   . LEU A 1 352 ? 63.360 47.498 65.830 1.00 0.63 ? 352 LEU A O   1 
ATOM 2680 C CB  . LEU A 1 352 ? 66.551 47.309 66.516 1.00 0.63 ? 352 LEU A CB  1 
ATOM 2681 C CG  . LEU A 1 352 ? 67.544 48.410 66.061 1.00 0.63 ? 352 LEU A CG  1 
ATOM 2682 C CD1 . LEU A 1 352 ? 68.105 49.262 67.214 1.00 0.63 ? 352 LEU A CD1 1 
ATOM 2683 C CD2 . LEU A 1 352 ? 68.707 47.781 65.274 1.00 0.63 ? 352 LEU A CD2 1 
ATOM 2684 N N   . LEU A 1 353 ? 63.559 46.053 67.508 1.00 0.61 ? 353 LEU A N   1 
ATOM 2685 C CA  . LEU A 1 353 ? 62.279 45.416 67.231 1.00 0.61 ? 353 LEU A CA  1 
ATOM 2686 C C   . LEU A 1 353 ? 61.080 46.363 67.273 1.00 0.61 ? 353 LEU A C   1 
ATOM 2687 O O   . LEU A 1 353 ? 60.252 46.395 66.359 1.00 0.61 ? 353 LEU A O   1 
ATOM 2688 C CB  . LEU A 1 353 ? 62.036 44.315 68.285 1.00 0.61 ? 353 LEU A CB  1 
ATOM 2689 C CG  . LEU A 1 353 ? 62.831 43.016 68.049 1.00 0.61 ? 353 LEU A CG  1 
ATOM 2690 C CD1 . LEU A 1 353 ? 62.969 42.220 69.355 1.00 0.61 ? 353 LEU A CD1 1 
ATOM 2691 C CD2 . LEU A 1 353 ? 62.176 42.142 66.970 1.00 0.61 ? 353 LEU A CD2 1 
ATOM 2692 N N   . ASN A 1 354 ? 60.978 47.202 68.316 1.00 0.60 ? 354 ASN A N   1 
ATOM 2693 C CA  . ASN A 1 354 ? 59.904 48.164 68.492 1.00 0.60 ? 354 ASN A CA  1 
ATOM 2694 C C   . ASN A 1 354 ? 59.907 49.293 67.500 1.00 0.60 ? 354 ASN A C   1 
ATOM 2695 O O   . ASN A 1 354 ? 58.861 49.821 67.141 1.00 0.60 ? 354 ASN A O   1 
ATOM 2696 C CB  . ASN A 1 354 ? 59.923 48.731 69.916 1.00 0.60 ? 354 ASN A CB  1 
ATOM 2697 C CG  . ASN A 1 354 ? 59.756 47.525 70.841 1.00 0.60 ? 354 ASN A CG  1 
ATOM 2698 O OD1 . ASN A 1 354 ? 60.709 46.814 71.147 1.00 0.60 ? 354 ASN A OD1 1 
ATOM 2699 N ND2 . ASN A 1 354 ? 58.494 47.144 71.147 1.00 0.60 ? 354 ASN A ND2 1 
ATOM 2700 N N   . LYS A 1 355 ? 61.094 49.673 67.012 1.00 0.59 ? 355 LYS A N   1 
ATOM 2701 C CA  . LYS A 1 355 ? 61.222 50.651 65.954 1.00 0.59 ? 355 LYS A CA  1 
ATOM 2702 C C   . LYS A 1 355 ? 60.775 50.163 64.578 1.00 0.59 ? 355 LYS A C   1 
ATOM 2703 O O   . LYS A 1 355 ? 60.435 50.981 63.727 1.00 0.59 ? 355 LYS A O   1 
ATOM 2704 C CB  . LYS A 1 355 ? 62.695 51.111 65.851 1.00 0.59 ? 355 LYS A CB  1 
ATOM 2705 C CG  . LYS A 1 355 ? 63.133 52.007 67.020 1.00 0.59 ? 355 LYS A CG  1 
ATOM 2706 C CD  . LYS A 1 355 ? 64.630 52.353 66.954 1.00 0.59 ? 355 LYS A CD  1 
ATOM 2707 C CE  . LYS A 1 355 ? 65.094 53.363 68.009 1.00 0.59 ? 355 LYS A CE  1 
ATOM 2708 N NZ  . LYS A 1 355 ? 64.727 54.736 67.589 1.00 0.59 ? 355 LYS A NZ  1 
ATOM 2709 N N   . HIS A 1 356 ? 60.766 48.839 64.309 1.00 0.65 ? 356 HIS A N   1 
ATOM 2710 C CA  . HIS A 1 356 ? 60.647 48.355 62.943 1.00 0.65 ? 356 HIS A CA  1 
ATOM 2711 C C   . HIS A 1 356 ? 59.549 47.327 62.674 1.00 0.65 ? 356 HIS A C   1 
ATOM 2712 O O   . HIS A 1 356 ? 59.174 47.146 61.513 1.00 0.65 ? 356 HIS A O   1 
ATOM 2713 C CB  . HIS A 1 356 ? 62.013 47.814 62.477 1.00 0.65 ? 356 HIS A CB  1 
ATOM 2714 C CG  . HIS A 1 356 ? 63.049 48.901 62.399 1.00 0.65 ? 356 HIS A CG  1 
ATOM 2715 N ND1 . HIS A 1 356 ? 64.140 48.866 63.238 1.00 0.65 ? 356 HIS A ND1 1 
ATOM 2716 C CD2 . HIS A 1 356 ? 63.105 50.008 61.611 1.00 0.65 ? 356 HIS A CD2 1 
ATOM 2717 C CE1 . HIS A 1 356 ? 64.833 49.950 62.960 1.00 0.65 ? 356 HIS A CE1 1 
ATOM 2718 N NE2 . HIS A 1 356 ? 64.251 50.680 61.981 1.00 0.65 ? 356 HIS A NE2 1 
ATOM 2719 N N   . ILE A 1 357 ? 58.977 46.643 63.690 1.00 0.62 ? 357 ILE A N   1 
ATOM 2720 C CA  . ILE A 1 357 ? 57.768 45.818 63.562 1.00 0.62 ? 357 ILE A CA  1 
ATOM 2721 C C   . ILE A 1 357 ? 56.503 46.665 63.364 1.00 0.62 ? 357 ILE A C   1 
ATOM 2722 O O   . ILE A 1 357 ? 56.259 47.602 64.116 1.00 0.62 ? 357 ILE A O   1 
ATOM 2723 C CB  . ILE A 1 357 ? 57.609 44.865 64.757 1.00 0.62 ? 357 ILE A CB  1 
ATOM 2724 C CG1 . ILE A 1 357 ? 58.696 43.765 64.695 1.00 0.62 ? 357 ILE A CG1 1 
ATOM 2725 C CG2 . ILE A 1 357 ? 56.197 44.228 64.826 1.00 0.62 ? 357 ILE A CG2 1 
ATOM 2726 C CD1 . ILE A 1 357 ? 58.798 42.901 65.957 1.00 0.62 ? 357 ILE A CD1 1 
ATOM 2727 N N   . ASP A 1 358 ? 55.689 46.369 62.310 1.00 0.61 ? 358 ASP A N   1 
ATOM 2728 C CA  . ASP A 1 358 ? 54.419 47.024 61.964 1.00 0.61 ? 358 ASP A CA  1 
ATOM 2729 C C   . ASP A 1 358 ? 54.595 48.527 61.672 1.00 0.61 ? 358 ASP A C   1 
ATOM 2730 O O   . ASP A 1 358 ? 53.672 49.339 61.666 1.00 0.61 ? 358 ASP A O   1 
ATOM 2731 C CB  . ASP A 1 358 ? 53.292 46.709 63.001 1.00 0.61 ? 358 ASP A CB  1 
ATOM 2732 C CG  . ASP A 1 358 ? 51.869 46.978 62.522 1.00 0.61 ? 358 ASP A CG  1 
ATOM 2733 O OD1 . ASP A 1 358 ? 51.610 47.029 61.294 1.00 0.61 ? 358 ASP A OD1 1 
ATOM 2734 O OD2 . ASP A 1 358 ? 50.978 47.114 63.409 1.00 0.61 ? 358 ASP A OD2 1 
ATOM 2735 N N   . ALA A 1 359 ? 55.838 48.953 61.369 1.00 0.69 ? 359 ALA A N   1 
ATOM 2736 C CA  . ALA A 1 359 ? 56.222 50.341 61.509 1.00 0.69 ? 359 ALA A CA  1 
ATOM 2737 C C   . ALA A 1 359 ? 55.685 51.299 60.454 1.00 0.69 ? 359 ALA A C   1 
ATOM 2738 O O   . ALA A 1 359 ? 55.652 52.505 60.656 1.00 0.69 ? 359 ALA A O   1 
ATOM 2739 C CB  . ALA A 1 359 ? 57.756 50.413 61.603 1.00 0.69 ? 359 ALA A CB  1 
ATOM 2740 N N   . TYR A 1 360 ? 55.175 50.777 59.324 1.00 0.54 ? 360 TYR A N   1 
ATOM 2741 C CA  . TYR A 1 360 ? 54.498 51.535 58.283 1.00 0.54 ? 360 TYR A CA  1 
ATOM 2742 C C   . TYR A 1 360 ? 53.145 52.113 58.742 1.00 0.54 ? 360 TYR A C   1 
ATOM 2743 O O   . TYR A 1 360 ? 52.632 53.081 58.179 1.00 0.54 ? 360 TYR A O   1 
ATOM 2744 C CB  . TYR A 1 360 ? 54.296 50.578 57.074 1.00 0.54 ? 360 TYR A CB  1 
ATOM 2745 C CG  . TYR A 1 360 ? 53.569 51.219 55.928 1.00 0.54 ? 360 TYR A CG  1 
ATOM 2746 C CD1 . TYR A 1 360 ? 54.130 52.297 55.223 1.00 0.54 ? 360 TYR A CD1 1 
ATOM 2747 C CD2 . TYR A 1 360 ? 52.278 50.782 55.602 1.00 0.54 ? 360 TYR A CD2 1 
ATOM 2748 C CE1 . TYR A 1 360 ? 53.406 52.929 54.202 1.00 0.54 ? 360 TYR A CE1 1 
ATOM 2749 C CE2 . TYR A 1 360 ? 51.564 51.405 54.578 1.00 0.54 ? 360 TYR A CE2 1 
ATOM 2750 C CZ  . TYR A 1 360 ? 52.124 52.478 53.888 1.00 0.54 ? 360 TYR A CZ  1 
ATOM 2751 O OH  . TYR A 1 360 ? 51.349 53.064 52.880 1.00 0.54 ? 360 TYR A OH  1 
ATOM 2752 N N   . LYS A 1 361 ? 52.525 51.532 59.785 1.00 0.55 ? 361 LYS A N   1 
ATOM 2753 C CA  . LYS A 1 361 ? 51.241 51.959 60.314 1.00 0.55 ? 361 LYS A CA  1 
ATOM 2754 C C   . LYS A 1 361 ? 51.202 53.382 60.856 1.00 0.55 ? 361 LYS A C   1 
ATOM 2755 O O   . LYS A 1 361 ? 50.143 54.000 60.880 1.00 0.55 ? 361 LYS A O   1 
ATOM 2756 C CB  . LYS A 1 361 ? 50.789 50.974 61.412 1.00 0.55 ? 361 LYS A CB  1 
ATOM 2757 C CG  . LYS A 1 361 ? 49.407 51.267 62.024 1.00 0.55 ? 361 LYS A CG  1 
ATOM 2758 C CD  . LYS A 1 361 ? 48.988 50.175 63.014 1.00 0.55 ? 361 LYS A CD  1 
ATOM 2759 C CE  . LYS A 1 361 ? 48.509 48.905 62.310 1.00 0.55 ? 361 LYS A CE  1 
ATOM 2760 N NZ  . LYS A 1 361 ? 48.486 47.779 63.256 1.00 0.55 ? 361 LYS A NZ  1 
ATOM 2761 N N   . THR A 1 362 ? 52.344 53.955 61.270 1.00 0.52 ? 362 THR A N   1 
ATOM 2762 C CA  . THR A 1 362 ? 52.387 55.294 61.830 1.00 0.52 ? 362 THR A CA  1 
ATOM 2763 C C   . THR A 1 362 ? 52.720 56.371 60.805 1.00 0.52 ? 362 THR A C   1 
ATOM 2764 O O   . THR A 1 362 ? 52.964 57.527 61.146 1.00 0.52 ? 362 THR A O   1 
ATOM 2765 C CB  . THR A 1 362 ? 53.342 55.390 63.001 1.00 0.52 ? 362 THR A CB  1 
ATOM 2766 O OG1 . THR A 1 362 ? 54.638 54.912 62.707 1.00 0.52 ? 362 THR A OG1 1 
ATOM 2767 C CG2 . THR A 1 362 ? 52.877 54.506 64.165 1.00 0.52 ? 362 THR A CG2 1 
ATOM 2768 N N   . PHE A 1 363 ? 52.705 56.041 59.494 1.00 0.45 ? 363 PHE A N   1 
ATOM 2769 C CA  . PHE A 1 363 ? 52.774 57.013 58.411 1.00 0.45 ? 363 PHE A CA  1 
ATOM 2770 C C   . PHE A 1 363 ? 51.521 57.928 58.390 1.00 0.45 ? 363 PHE A C   1 
ATOM 2771 O O   . PHE A 1 363 ? 50.438 57.445 58.711 1.00 0.45 ? 363 PHE A O   1 
ATOM 2772 C CB  . PHE A 1 363 ? 52.985 56.251 57.055 1.00 0.45 ? 363 PHE A CB  1 
ATOM 2773 C CG  . PHE A 1 363 ? 53.548 57.076 55.927 1.00 0.45 ? 363 PHE A CG  1 
ATOM 2774 C CD1 . PHE A 1 363 ? 54.695 57.857 56.121 1.00 0.45 ? 363 PHE A CD1 1 
ATOM 2775 C CD2 . PHE A 1 363 ? 52.959 57.057 54.648 1.00 0.45 ? 363 PHE A CD2 1 
ATOM 2776 C CE1 . PHE A 1 363 ? 55.187 58.673 55.097 1.00 0.45 ? 363 PHE A CE1 1 
ATOM 2777 C CE2 . PHE A 1 363 ? 53.444 57.878 53.621 1.00 0.45 ? 363 PHE A CE2 1 
ATOM 2778 C CZ  . PHE A 1 363 ? 54.553 58.698 53.852 1.00 0.45 ? 363 PHE A CZ  1 
ATOM 2779 N N   . PRO A 1 364 ? 51.513 59.218 58.029 1.00 0.34 ? 364 PRO A N   1 
ATOM 2780 C CA  . PRO A 1 364 ? 50.312 60.068 58.091 1.00 0.34 ? 364 PRO A CA  1 
ATOM 2781 C C   . PRO A 1 364 ? 49.042 59.601 57.362 1.00 0.34 ? 364 PRO A C   1 
ATOM 2782 O O   . PRO A 1 364 ? 47.980 59.975 57.857 1.00 0.34 ? 364 PRO A O   1 
ATOM 2783 C CB  . PRO A 1 364 ? 50.787 61.441 57.578 1.00 0.34 ? 364 PRO A CB  1 
ATOM 2784 C CG  . PRO A 1 364 ? 52.302 61.441 57.799 1.00 0.34 ? 364 PRO A CG  1 
ATOM 2785 C CD  . PRO A 1 364 ? 52.691 59.975 57.623 1.00 0.34 ? 364 PRO A CD  1 
ATOM 2786 N N   . PRO A 1 365 ? 49.009 58.872 56.243 1.00 0.43 ? 365 PRO A N   1 
ATOM 2787 C CA  . PRO A 1 365 ? 47.773 58.322 55.698 1.00 0.43 ? 365 PRO A CA  1 
ATOM 2788 C C   . PRO A 1 365 ? 47.253 57.096 56.433 1.00 0.43 ? 365 PRO A C   1 
ATOM 2789 O O   . PRO A 1 365 ? 46.159 56.648 56.100 1.00 0.43 ? 365 PRO A O   1 
ATOM 2790 C CB  . PRO A 1 365 ? 48.159 57.888 54.265 1.00 0.43 ? 365 PRO A CB  1 
ATOM 2791 C CG  . PRO A 1 365 ? 49.414 58.690 53.932 1.00 0.43 ? 365 PRO A CG  1 
ATOM 2792 C CD  . PRO A 1 365 ? 50.101 58.788 55.285 1.00 0.43 ? 365 PRO A CD  1 
ATOM 2793 N N   . THR A 1 366 ? 48.032 56.460 57.330 1.00 0.29 ? 366 THR A N   1 
ATOM 2794 C CA  . THR A 1 366 ? 47.724 55.123 57.823 1.00 0.29 ? 366 THR A CA  1 
ATOM 2795 C C   . THR A 1 366 ? 47.259 55.095 59.271 1.00 0.29 ? 366 THR A C   1 
ATOM 2796 O O   . THR A 1 366 ? 46.785 54.052 59.725 1.00 0.29 ? 366 THR A O   1 
ATOM 2797 C CB  . THR A 1 366 ? 48.883 54.142 57.616 1.00 0.29 ? 366 THR A CB  1 
ATOM 2798 O OG1 . THR A 1 366 ? 50.126 54.703 57.986 1.00 0.29 ? 366 THR A OG1 1 
ATOM 2799 C CG2 . THR A 1 366 ? 49.041 53.836 56.118 1.00 0.29 ? 366 THR A CG2 1 
ATOM 2800 N N   . GLU A 1 367 ? 47.262 56.235 60.002 1.00 0.55 ? 367 GLU A N   1 
ATOM 2801 C CA  . GLU A 1 367 ? 46.650 56.322 61.317 1.00 0.55 ? 367 GLU A CA  1 
ATOM 2802 C C   . GLU A 1 367 ? 46.028 57.702 61.545 1.00 0.55 ? 367 GLU A C   1 
ATOM 2803 O O   . GLU A 1 367 ? 46.359 58.628 60.809 1.00 0.55 ? 367 GLU A O   1 
ATOM 2804 C CB  . GLU A 1 367 ? 47.632 55.958 62.468 1.00 0.55 ? 367 GLU A CB  1 
ATOM 2805 C CG  . GLU A 1 367 ? 48.833 56.915 62.694 1.00 0.55 ? 367 GLU A CG  1 
ATOM 2806 C CD  . GLU A 1 367 ? 49.609 56.589 63.979 1.00 0.55 ? 367 GLU A CD  1 
ATOM 2807 O OE1 . GLU A 1 367 ? 49.141 55.731 64.775 1.00 0.55 ? 367 GLU A OE1 1 
ATOM 2808 O OE2 . GLU A 1 367 ? 50.662 57.238 64.217 1.00 0.55 ? 367 GLU A OE2 1 
ATOM 2809 N N   . PRO A 1 368 ? 45.103 57.943 62.496 1.00 0.47 ? 368 PRO A N   1 
ATOM 2810 C CA  . PRO A 1 368 ? 44.371 59.213 62.559 1.00 0.47 ? 368 PRO A CA  1 
ATOM 2811 C C   . PRO A 1 368 ? 45.171 60.376 63.116 1.00 0.47 ? 368 PRO A C   1 
ATOM 2812 O O   . PRO A 1 368 ? 44.745 61.523 62.980 1.00 0.47 ? 368 PRO A O   1 
ATOM 2813 C CB  . PRO A 1 368 ? 43.194 58.926 63.516 1.00 0.47 ? 368 PRO A CB  1 
ATOM 2814 C CG  . PRO A 1 368 ? 43.015 57.410 63.476 1.00 0.47 ? 368 PRO A CG  1 
ATOM 2815 C CD  . PRO A 1 368 ? 44.444 56.904 63.292 1.00 0.47 ? 368 PRO A CD  1 
ATOM 2816 N N   . LYS A 1 369 ? 46.253 60.105 63.863 1.00 0.52 ? 369 LYS A N   1 
ATOM 2817 C CA  . LYS A 1 369 ? 47.003 61.121 64.571 1.00 0.52 ? 369 LYS A CA  1 
ATOM 2818 C C   . LYS A 1 369 ? 47.835 62.047 63.697 1.00 0.52 ? 369 LYS A C   1 
ATOM 2819 O O   . LYS A 1 369 ? 48.586 61.639 62.818 1.00 0.52 ? 369 LYS A O   1 
ATOM 2820 C CB  . LYS A 1 369 ? 47.895 60.495 65.669 1.00 0.52 ? 369 LYS A CB  1 
ATOM 2821 C CG  . LYS A 1 369 ? 47.070 59.782 66.752 1.00 0.52 ? 369 LYS A CG  1 
ATOM 2822 C CD  . LYS A 1 369 ? 47.937 59.193 67.876 1.00 0.52 ? 369 LYS A CD  1 
ATOM 2823 C CE  . LYS A 1 369 ? 47.099 58.495 68.949 1.00 0.52 ? 369 LYS A CE  1 
ATOM 2824 N NZ  . LYS A 1 369 ? 47.967 57.951 70.016 1.00 0.52 ? 369 LYS A NZ  1 
ATOM 2825 N N   . LYS A 1 370 ? 47.741 63.364 63.963 1.00 0.53 ? 370 LYS A N   1 
ATOM 2826 C CA  . LYS A 1 370 ? 48.605 64.348 63.350 1.00 0.53 ? 370 LYS A CA  1 
ATOM 2827 C C   . LYS A 1 370 ? 49.988 64.390 63.983 1.00 0.53 ? 370 LYS A C   1 
ATOM 2828 O O   . LYS A 1 370 ? 50.177 63.941 65.113 1.00 0.53 ? 370 LYS A O   1 
ATOM 2829 C CB  . LYS A 1 370 ? 47.972 65.759 63.440 1.00 0.53 ? 370 LYS A CB  1 
ATOM 2830 C CG  . LYS A 1 370 ? 47.870 66.333 64.870 1.00 0.53 ? 370 LYS A CG  1 
ATOM 2831 C CD  . LYS A 1 370 ? 47.144 67.692 64.937 1.00 0.53 ? 370 LYS A CD  1 
ATOM 2832 C CE  . LYS A 1 370 ? 47.866 68.809 64.169 1.00 0.53 ? 370 LYS A CE  1 
ATOM 2833 N NZ  . LYS A 1 370 ? 47.145 70.098 64.302 1.00 0.53 ? 370 LYS A NZ  1 
ATOM 2834 N N   . ASP A 1 371 ? 50.989 64.978 63.281 1.00 0.55 ? 371 ASP A N   1 
ATOM 2835 C CA  . ASP A 1 371 ? 52.309 65.213 63.830 1.00 0.55 ? 371 ASP A CA  1 
ATOM 2836 C C   . ASP A 1 371 ? 52.259 66.126 65.068 1.00 0.55 ? 371 ASP A C   1 
ATOM 2837 O O   . ASP A 1 371 ? 51.718 67.239 65.063 1.00 0.55 ? 371 ASP A O   1 
ATOM 2838 C CB  . ASP A 1 371 ? 53.261 65.723 62.712 1.00 0.55 ? 371 ASP A CB  1 
ATOM 2839 C CG  . ASP A 1 371 ? 54.692 65.906 63.203 1.00 0.55 ? 371 ASP A CG  1 
ATOM 2840 O OD1 . ASP A 1 371 ? 55.018 65.384 64.302 1.00 0.55 ? 371 ASP A OD1 1 
ATOM 2841 O OD2 . ASP A 1 371 ? 55.456 66.606 62.502 1.00 0.55 ? 371 ASP A OD2 1 
ATOM 2842 N N   . LYS A 1 372 ? 52.807 65.617 66.185 1.00 0.57 ? 372 LYS A N   1 
ATOM 2843 C CA  . LYS A 1 372 ? 52.933 66.330 67.426 1.00 0.57 ? 372 LYS A CA  1 
ATOM 2844 C C   . LYS A 1 372 ? 54.376 66.648 67.765 1.00 0.57 ? 372 LYS A C   1 
ATOM 2845 O O   . LYS A 1 372 ? 54.620 67.260 68.803 1.00 0.57 ? 372 LYS A O   1 
ATOM 2846 C CB  . LYS A 1 372 ? 52.334 65.484 68.577 1.00 0.57 ? 372 LYS A CB  1 
ATOM 2847 C CG  . LYS A 1 372 ? 50.832 65.174 68.441 1.00 0.57 ? 372 LYS A CG  1 
ATOM 2848 C CD  . LYS A 1 372 ? 49.918 66.411 68.469 1.00 0.57 ? 372 LYS A CD  1 
ATOM 2849 C CE  . LYS A 1 372 ? 50.000 67.174 69.794 1.00 0.57 ? 372 LYS A CE  1 
ATOM 2850 N NZ  . LYS A 1 372 ? 49.020 68.282 69.824 1.00 0.57 ? 372 LYS A NZ  1 
ATOM 2851 N N   . LYS A 1 373 ? 55.364 66.279 66.917 1.00 0.58 ? 373 LYS A N   1 
ATOM 2852 C CA  . LYS A 1 373 ? 56.776 66.460 67.213 1.00 0.58 ? 373 LYS A CA  1 
ATOM 2853 C C   . LYS A 1 373 ? 57.215 67.917 67.280 1.00 0.58 ? 373 LYS A C   1 
ATOM 2854 O O   . LYS A 1 373 ? 57.995 68.317 68.143 1.00 0.58 ? 373 LYS A O   1 
ATOM 2855 C CB  . LYS A 1 373 ? 57.628 65.715 66.156 1.00 0.58 ? 373 LYS A CB  1 
ATOM 2856 C CG  . LYS A 1 373 ? 59.107 65.528 66.538 1.00 0.58 ? 373 LYS A CG  1 
ATOM 2857 C CD  . LYS A 1 373 ? 59.929 64.961 65.366 1.00 0.58 ? 373 LYS A CD  1 
ATOM 2858 C CE  . LYS A 1 373 ? 61.426 64.818 65.656 1.00 0.58 ? 373 LYS A CE  1 
ATOM 2859 N NZ  . LYS A 1 373 ? 62.231 64.444 64.477 1.00 0.58 ? 373 LYS A NZ  1 
ATOM 2860 N N   . LYS A 1 374 ? 56.729 68.756 66.335 1.00 0.53 ? 374 LYS A N   1 
ATOM 2861 C CA  . LYS A 1 374 ? 56.971 70.196 66.275 1.00 0.53 ? 374 LYS A CA  1 
ATOM 2862 C C   . LYS A 1 374 ? 58.441 70.613 66.262 1.00 0.53 ? 374 LYS A C   1 
ATOM 2863 O O   . LYS A 1 374 ? 58.807 71.687 66.740 1.00 0.53 ? 374 LYS A O   1 
ATOM 2864 C CB  . LYS A 1 374 ? 56.188 70.966 67.374 1.00 0.53 ? 374 LYS A CB  1 
ATOM 2865 C CG  . LYS A 1 374 ? 54.665 70.783 67.273 1.00 0.53 ? 374 LYS A CG  1 
ATOM 2866 C CD  . LYS A 1 374 ? 53.873 71.556 68.346 1.00 0.53 ? 374 LYS A CD  1 
ATOM 2867 C CE  . LYS A 1 374 ? 53.981 73.081 68.212 1.00 0.53 ? 374 LYS A CE  1 
ATOM 2868 N NZ  . LYS A 1 374 ? 53.132 73.768 69.214 1.00 0.53 ? 374 LYS A NZ  1 
ATOM 2869 N N   . LYS A 1 375 ? 59.301 69.755 65.676 1.00 0.50 ? 375 LYS A N   1 
ATOM 2870 C CA  . LYS A 1 375 ? 60.748 69.876 65.637 1.00 0.50 ? 375 LYS A CA  1 
ATOM 2871 C C   . LYS A 1 375 ? 61.415 70.031 67.008 1.00 0.50 ? 375 LYS A C   1 
ATOM 2872 O O   . LYS A 1 375 ? 62.432 70.713 67.137 1.00 0.50 ? 375 LYS A O   1 
ATOM 2873 C CB  . LYS A 1 375 ? 61.209 70.987 64.657 1.00 0.50 ? 375 LYS A CB  1 
ATOM 2874 C CG  . LYS A 1 375 ? 60.711 70.771 63.217 1.00 0.50 ? 375 LYS A CG  1 
ATOM 2875 C CD  . LYS A 1 375 ? 61.133 71.885 62.242 1.00 0.50 ? 375 LYS A CD  1 
ATOM 2876 C CE  . LYS A 1 375 ? 62.645 71.945 62.012 1.00 0.50 ? 375 LYS A CE  1 
ATOM 2877 N NZ  . LYS A 1 375 ? 62.976 73.002 61.031 1.00 0.50 ? 375 LYS A NZ  1 
ATOM 2878 N N   . ALA A 1 376 ? 60.875 69.377 68.055 1.00 0.49 ? 376 ALA A N   1 
ATOM 2879 C CA  . ALA A 1 376 ? 61.310 69.576 69.416 1.00 0.49 ? 376 ALA A CA  1 
ATOM 2880 C C   . ALA A 1 376 ? 61.178 68.286 70.208 1.00 0.49 ? 376 ALA A C   1 
ATOM 2881 O O   . ALA A 1 376 ? 60.634 67.295 69.723 1.00 0.49 ? 376 ALA A O   1 
ATOM 2882 C CB  . ALA A 1 376 ? 60.445 70.678 70.054 1.00 0.49 ? 376 ALA A CB  1 
ATOM 2883 N N   . ASP A 1 377 ? 61.743 68.274 71.433 1.00 0.46 ? 377 ASP A N   1 
ATOM 2884 C CA  . ASP A 1 377 ? 61.646 67.220 72.434 1.00 0.46 ? 377 ASP A CA  1 
ATOM 2885 C C   . ASP A 1 377 ? 62.081 65.826 71.982 1.00 0.46 ? 377 ASP A C   1 
ATOM 2886 O O   . ASP A 1 377 ? 61.544 64.802 72.406 1.00 0.46 ? 377 ASP A O   1 
ATOM 2887 C CB  . ASP A 1 377 ? 60.250 67.218 73.105 1.00 0.46 ? 377 ASP A CB  1 
ATOM 2888 C CG  . ASP A 1 377 ? 59.935 68.567 73.739 1.00 0.46 ? 377 ASP A CG  1 
ATOM 2889 O OD1 . ASP A 1 377 ? 60.882 69.379 73.927 1.00 0.46 ? 377 ASP A OD1 1 
ATOM 2890 O OD2 . ASP A 1 377 ? 58.740 68.794 74.050 1.00 0.46 ? 377 ASP A OD2 1 
ATOM 2891 N N   . GLU A 1 378 ? 63.116 65.747 71.121 1.00 0.50 ? 378 GLU A N   1 
ATOM 2892 C CA  . GLU A 1 378 ? 63.691 64.501 70.662 1.00 0.50 ? 378 GLU A CA  1 
ATOM 2893 C C   . GLU A 1 378 ? 64.350 63.690 71.771 1.00 0.50 ? 378 GLU A C   1 
ATOM 2894 O O   . GLU A 1 378 ? 65.109 64.208 72.588 1.00 0.50 ? 378 GLU A O   1 
ATOM 2895 C CB  . GLU A 1 378 ? 64.687 64.747 69.500 1.00 0.50 ? 378 GLU A CB  1 
ATOM 2896 C CG  . GLU A 1 378 ? 64.010 65.388 68.263 1.00 0.50 ? 378 GLU A CG  1 
ATOM 2897 C CD  . GLU A 1 378 ? 64.913 65.446 67.029 1.00 0.50 ? 378 GLU A CD  1 
ATOM 2898 O OE1 . GLU A 1 378 ? 66.101 65.821 67.170 1.00 0.50 ? 378 GLU A OE1 1 
ATOM 2899 O OE2 . GLU A 1 378 ? 64.396 65.132 65.922 1.00 0.50 ? 378 GLU A OE2 1 
ATOM 2900 N N   . THR A 1 379 ? 64.086 62.365 71.818 1.00 0.49 ? 379 THR A N   1 
ATOM 2901 C CA  . THR A 1 379 ? 64.591 61.484 72.877 1.00 0.49 ? 379 THR A CA  1 
ATOM 2902 C C   . THR A 1 379 ? 66.098 61.299 72.884 1.00 0.49 ? 379 THR A C   1 
ATOM 2903 O O   . THR A 1 379 ? 66.696 61.042 73.924 1.00 0.49 ? 379 THR A O   1 
ATOM 2904 C CB  . THR A 1 379 ? 63.900 60.122 72.850 1.00 0.49 ? 379 THR A CB  1 
ATOM 2905 O OG1 . THR A 1 379 ? 62.515 60.311 73.075 1.00 0.49 ? 379 THR A OG1 1 
ATOM 2906 C CG2 . THR A 1 379 ? 64.340 59.147 73.951 1.00 0.49 ? 379 THR A CG2 1 
ATOM 2907 N N   . GLN A 1 380 ? 66.757 61.409 71.708 1.00 0.37 ? 380 GLN A N   1 
ATOM 2908 C CA  . GLN A 1 380 ? 68.198 61.238 71.544 1.00 0.37 ? 380 GLN A CA  1 
ATOM 2909 C C   . GLN A 1 380 ? 68.716 59.891 72.041 1.00 0.37 ? 380 GLN A C   1 
ATOM 2910 O O   . GLN A 1 380 ? 69.632 59.767 72.852 1.00 0.37 ? 380 GLN A O   1 
ATOM 2911 C CB  . GLN A 1 380 ? 68.989 62.461 72.080 1.00 0.37 ? 380 GLN A CB  1 
ATOM 2912 C CG  . GLN A 1 380 ? 70.480 62.553 71.665 1.00 0.37 ? 380 GLN A CG  1 
ATOM 2913 C CD  . GLN A 1 380 ? 70.681 62.738 70.162 1.00 0.37 ? 380 GLN A CD  1 
ATOM 2914 O OE1 . GLN A 1 380 ? 69.764 62.941 69.369 1.00 0.37 ? 380 GLN A OE1 1 
ATOM 2915 N NE2 . GLN A 1 380 ? 71.962 62.659 69.734 1.00 0.37 ? 380 GLN A NE2 1 
ATOM 2916 N N   . ALA A 1 381 ? 68.071 58.817 71.544 1.00 0.45 ? 381 ALA A N   1 
ATOM 2917 C CA  . ALA A 1 381 ? 68.340 57.445 71.910 1.00 0.45 ? 381 ALA A CA  1 
ATOM 2918 C C   . ALA A 1 381 ? 69.698 56.928 71.443 1.00 0.45 ? 381 ALA A C   1 
ATOM 2919 O O   . ALA A 1 381 ? 70.347 57.496 70.576 1.00 0.45 ? 381 ALA A O   1 
ATOM 2920 C CB  . ALA A 1 381 ? 67.200 56.546 71.378 1.00 0.45 ? 381 ALA A CB  1 
ATOM 2921 N N   . LEU A 1 382 ? 70.148 55.800 72.033 1.00 0.39 ? 382 LEU A N   1 
ATOM 2922 C CA  . LEU A 1 382 ? 71.453 55.203 71.791 1.00 0.39 ? 382 LEU A CA  1 
ATOM 2923 C C   . LEU A 1 382 ? 71.813 54.797 70.348 1.00 0.39 ? 382 LEU A C   1 
ATOM 2924 O O   . LEU A 1 382 ? 72.955 55.058 69.957 1.00 0.39 ? 382 LEU A O   1 
ATOM 2925 C CB  . LEU A 1 382 ? 71.599 53.986 72.749 1.00 0.39 ? 382 LEU A CB  1 
ATOM 2926 C CG  . LEU A 1 382 ? 72.959 53.251 72.740 1.00 0.39 ? 382 LEU A CG  1 
ATOM 2927 C CD1 . LEU A 1 382 ? 74.104 54.161 73.215 1.00 0.39 ? 382 LEU A CD1 1 
ATOM 2928 C CD2 . LEU A 1 382 ? 72.884 51.985 73.610 1.00 0.39 ? 382 LEU A CD2 1 
ATOM 2929 N N   . PRO A 1 383 ? 70.994 54.167 69.497 1.00 0.48 ? 383 PRO A N   1 
ATOM 2930 C CA  . PRO A 1 383 ? 71.449 53.770 68.171 1.00 0.48 ? 383 PRO A CA  1 
ATOM 2931 C C   . PRO A 1 383 ? 71.483 54.930 67.190 1.00 0.48 ? 383 PRO A C   1 
ATOM 2932 O O   . PRO A 1 383 ? 70.559 55.741 67.147 1.00 0.48 ? 383 PRO A O   1 
ATOM 2933 C CB  . PRO A 1 383 ? 70.445 52.692 67.727 1.00 0.48 ? 383 PRO A CB  1 
ATOM 2934 C CG  . PRO A 1 383 ? 69.179 53.003 68.523 1.00 0.48 ? 383 PRO A CG  1 
ATOM 2935 C CD  . PRO A 1 383 ? 69.726 53.535 69.846 1.00 0.48 ? 383 PRO A CD  1 
ATOM 2936 N N   . GLN A 1 384 ? 72.547 54.991 66.365 1.00 0.49 ? 384 GLN A N   1 
ATOM 2937 C CA  . GLN A 1 384 ? 72.774 56.033 65.386 1.00 0.49 ? 384 GLN A CA  1 
ATOM 2938 C C   . GLN A 1 384 ? 71.904 55.930 64.138 1.00 0.49 ? 384 GLN A C   1 
ATOM 2939 O O   . GLN A 1 384 ? 71.321 54.888 63.835 1.00 0.49 ? 384 GLN A O   1 
ATOM 2940 C CB  . GLN A 1 384 ? 74.271 56.040 64.959 1.00 0.49 ? 384 GLN A CB  1 
ATOM 2941 C CG  . GLN A 1 384 ? 74.730 54.778 64.172 1.00 0.49 ? 384 GLN A CG  1 
ATOM 2942 C CD  . GLN A 1 384 ? 76.195 54.836 63.725 1.00 0.49 ? 384 GLN A CD  1 
ATOM 2943 O OE1 . GLN A 1 384 ? 76.522 54.785 62.534 1.00 0.49 ? 384 GLN A OE1 1 
ATOM 2944 N NE2 . GLN A 1 384 ? 77.110 54.917 64.716 1.00 0.49 ? 384 GLN A NE2 1 
ATOM 2945 N N   . ARG A 1 385 ? 71.826 57.023 63.346 1.00 0.53 ? 385 ARG A N   1 
ATOM 2946 C CA  . ARG A 1 385 ? 71.186 57.010 62.045 1.00 0.53 ? 385 ARG A CA  1 
ATOM 2947 C C   . ARG A 1 385 ? 72.175 57.510 61.006 1.00 0.53 ? 385 ARG A C   1 
ATOM 2948 O O   . ARG A 1 385 ? 73.082 58.282 61.307 1.00 0.53 ? 385 ARG A O   1 
ATOM 2949 C CB  . ARG A 1 385 ? 69.880 57.846 62.027 1.00 0.53 ? 385 ARG A CB  1 
ATOM 2950 C CG  . ARG A 1 385 ? 68.961 57.564 60.818 1.00 0.53 ? 385 ARG A CG  1 
ATOM 2951 C CD  . ARG A 1 385 ? 67.613 58.299 60.819 1.00 0.53 ? 385 ARG A CD  1 
ATOM 2952 N NE  . ARG A 1 385 ? 67.881 59.740 60.519 1.00 0.53 ? 385 ARG A NE  1 
ATOM 2953 C CZ  . ARG A 1 385 ? 66.923 60.681 60.523 1.00 0.53 ? 385 ARG A CZ  1 
ATOM 2954 N NH1 . ARG A 1 385 ? 67.293 61.946 60.346 1.00 0.53 ? 385 ARG A NH1 1 
ATOM 2955 N NH2 . ARG A 1 385 ? 65.641 60.397 60.686 1.00 0.53 ? 385 ARG A NH2 1 
ATOM 2956 N N   . GLN A 1 386 ? 72.042 57.039 59.749 1.00 0.61 ? 386 GLN A N   1 
ATOM 2957 C CA  . GLN A 1 386 ? 72.962 57.296 58.654 1.00 0.61 ? 386 GLN A CA  1 
ATOM 2958 C C   . GLN A 1 386 ? 72.994 58.724 58.123 1.00 0.61 ? 386 GLN A C   1 
ATOM 2959 O O   . GLN A 1 386 ? 73.986 59.151 57.540 1.00 0.61 ? 386 GLN A O   1 
ATOM 2960 C CB  . GLN A 1 386 ? 72.605 56.322 57.508 1.00 0.61 ? 386 GLN A CB  1 
ATOM 2961 C CG  . GLN A 1 386 ? 73.583 56.286 56.308 1.00 0.61 ? 386 GLN A CG  1 
ATOM 2962 C CD  . GLN A 1 386 ? 73.201 55.128 55.377 1.00 0.61 ? 386 GLN A CD  1 
ATOM 2963 O OE1 . GLN A 1 386 ? 72.303 54.352 55.712 1.00 0.61 ? 386 GLN A OE1 1 
ATOM 2964 N NE2 . GLN A 1 386 ? 73.897 55.014 54.227 1.00 0.61 ? 386 GLN A NE2 1 
ATOM 2965 N N   . LYS A 1 387 ? 71.916 59.509 58.314 1.00 0.56 ? 387 LYS A N   1 
ATOM 2966 C CA  . LYS A 1 387 ? 71.819 60.820 57.711 1.00 0.56 ? 387 LYS A CA  1 
ATOM 2967 C C   . LYS A 1 387 ? 71.014 61.768 58.579 1.00 0.56 ? 387 LYS A C   1 
ATOM 2968 O O   . LYS A 1 387 ? 70.180 61.358 59.392 1.00 0.56 ? 387 LYS A O   1 
ATOM 2969 C CB  . LYS A 1 387 ? 71.231 60.726 56.282 1.00 0.56 ? 387 LYS A CB  1 
ATOM 2970 C CG  . LYS A 1 387 ? 69.787 60.207 56.211 1.00 0.56 ? 387 LYS A CG  1 
ATOM 2971 C CD  . LYS A 1 387 ? 69.426 59.612 54.839 1.00 0.56 ? 387 LYS A CD  1 
ATOM 2972 C CE  . LYS A 1 387 ? 69.608 60.569 53.654 1.00 0.56 ? 387 LYS A CE  1 
ATOM 2973 N NZ  . LYS A 1 387 ? 69.064 59.941 52.431 1.00 0.56 ? 387 LYS A NZ  1 
ATOM 2974 N N   . LYS A 1 388 ? 71.306 63.081 58.459 1.00 0.48 ? 388 LYS A N   1 
ATOM 2975 C CA  . LYS A 1 388 ? 70.722 64.120 59.287 1.00 0.48 ? 388 LYS A CA  1 
ATOM 2976 C C   . LYS A 1 388 ? 69.289 64.491 58.931 1.00 0.48 ? 388 LYS A C   1 
ATOM 2977 O O   . LYS A 1 388 ? 68.448 64.572 59.819 1.00 0.48 ? 388 LYS A O   1 
ATOM 2978 C CB  . LYS A 1 388 ? 71.616 65.386 59.268 1.00 0.48 ? 388 LYS A CB  1 
ATOM 2979 C CG  . LYS A 1 388 ? 73.083 65.158 59.695 1.00 0.48 ? 388 LYS A CG  1 
ATOM 2980 C CD  . LYS A 1 388 ? 73.264 64.698 61.155 1.00 0.48 ? 388 LYS A CD  1 
ATOM 2981 C CE  . LYS A 1 388 ? 74.743 64.610 61.558 1.00 0.48 ? 388 LYS A CE  1 
ATOM 2982 N NZ  . LYS A 1 388 ? 74.889 64.171 62.967 1.00 0.48 ? 388 LYS A NZ  1 
ATOM 2983 N N   . GLN A 1 389 ? 68.958 64.685 57.637 1.00 0.50 ? 389 GLN A N   1 
ATOM 2984 C CA  . GLN A 1 389 ? 67.634 65.129 57.233 1.00 0.50 ? 389 GLN A CA  1 
ATOM 2985 C C   . GLN A 1 389 ? 67.332 64.621 55.831 1.00 0.50 ? 389 GLN A C   1 
ATOM 2986 O O   . GLN A 1 389 ? 68.246 64.448 55.028 1.00 0.50 ? 389 GLN A O   1 
ATOM 2987 C CB  . GLN A 1 389 ? 67.572 66.688 57.278 1.00 0.50 ? 389 GLN A CB  1 
ATOM 2988 C CG  . GLN A 1 389 ? 66.316 67.396 56.697 1.00 0.50 ? 389 GLN A CG  1 
ATOM 2989 C CD  . GLN A 1 389 ? 65.025 67.035 57.431 1.00 0.50 ? 389 GLN A CD  1 
ATOM 2990 O OE1 . GLN A 1 389 ? 64.955 66.106 58.230 1.00 0.50 ? 389 GLN A OE1 1 
ATOM 2991 N NE2 . GLN A 1 389 ? 63.939 67.780 57.124 1.00 0.50 ? 389 GLN A NE2 1 
ATOM 2992 N N   . GLN A 1 390 ? 66.043 64.353 55.499 1.00 0.57 ? 390 GLN A N   1 
ATOM 2993 C CA  . GLN A 1 390 ? 65.630 64.092 54.126 1.00 0.57 ? 390 GLN A CA  1 
ATOM 2994 C C   . GLN A 1 390 ? 64.142 64.374 53.928 1.00 0.57 ? 390 GLN A C   1 
ATOM 2995 O O   . GLN A 1 390 ? 63.344 64.187 54.840 1.00 0.57 ? 390 GLN A O   1 
ATOM 2996 C CB  . GLN A 1 390 ? 65.919 62.625 53.690 1.00 0.57 ? 390 GLN A CB  1 
ATOM 2997 C CG  . GLN A 1 390 ? 65.213 61.540 54.543 1.00 0.57 ? 390 GLN A CG  1 
ATOM 2998 C CD  . GLN A 1 390 ? 65.722 60.138 54.210 1.00 0.57 ? 390 GLN A CD  1 
ATOM 2999 O OE1 . GLN A 1 390 ? 66.452 59.914 53.241 1.00 0.57 ? 390 GLN A OE1 1 
ATOM 3000 N NE2 . GLN A 1 390 ? 65.345 59.153 55.061 1.00 0.57 ? 390 GLN A NE2 1 
ATOM 3001 N N   . THR A 1 391 ? 63.720 64.804 52.717 1.00 0.54 ? 391 THR A N   1 
ATOM 3002 C CA  . THR A 1 391 ? 62.302 64.907 52.356 1.00 0.54 ? 391 THR A CA  1 
ATOM 3003 C C   . THR A 1 391 ? 62.181 64.699 50.857 1.00 0.54 ? 391 THR A C   1 
ATOM 3004 O O   . THR A 1 391 ? 63.063 65.100 50.103 1.00 0.54 ? 391 THR A O   1 
ATOM 3005 C CB  . THR A 1 391 ? 61.592 66.204 52.786 1.00 0.54 ? 391 THR A CB  1 
ATOM 3006 O OG1 . THR A 1 391 ? 60.251 66.276 52.315 1.00 0.54 ? 391 THR A OG1 1 
ATOM 3007 C CG2 . THR A 1 391 ? 62.301 67.466 52.273 1.00 0.54 ? 391 THR A CG2 1 
ATOM 3008 N N   . VAL A 1 392 ? 61.102 64.027 50.397 1.00 0.52 ? 392 VAL A N   1 
ATOM 3009 C CA  . VAL A 1 392 ? 60.795 63.741 49.003 1.00 0.52 ? 392 VAL A CA  1 
ATOM 3010 C C   . VAL A 1 392 ? 59.282 63.768 48.972 1.00 0.52 ? 392 VAL A C   1 
ATOM 3011 O O   . VAL A 1 392 ? 58.672 63.381 49.964 1.00 0.52 ? 392 VAL A O   1 
ATOM 3012 C CB  . VAL A 1 392 ? 61.278 62.360 48.533 1.00 0.52 ? 392 VAL A CB  1 
ATOM 3013 C CG1 . VAL A 1 392 ? 60.757 61.985 47.124 1.00 0.52 ? 392 VAL A CG1 1 
ATOM 3014 C CG2 . VAL A 1 392 ? 62.817 62.329 48.525 1.00 0.52 ? 392 VAL A CG2 1 
ATOM 3015 N N   . THR A 1 393 ? 58.644 64.279 47.885 1.00 0.46 ? 393 THR A N   1 
ATOM 3016 C CA  . THR A 1 393 ? 57.182 64.336 47.679 1.00 0.46 ? 393 THR A CA  1 
ATOM 3017 C C   . THR A 1 393 ? 56.403 64.996 48.805 1.00 0.46 ? 393 THR A C   1 
ATOM 3018 O O   . THR A 1 393 ? 55.241 64.685 49.064 1.00 0.46 ? 393 THR A O   1 
ATOM 3019 C CB  . THR A 1 393 ? 56.496 63.032 47.235 1.00 0.46 ? 393 THR A CB  1 
ATOM 3020 O OG1 . THR A 1 393 ? 56.847 61.910 48.029 1.00 0.46 ? 393 THR A OG1 1 
ATOM 3021 C CG2 . THR A 1 393 ? 56.900 62.674 45.799 1.00 0.46 ? 393 THR A CG2 1 
ATOM 3022 N N   . LEU A 1 394 ? 57.056 65.971 49.477 1.00 0.41 ? 394 LEU A N   1 
ATOM 3023 C CA  . LEU A 1 394 ? 56.576 66.712 50.631 1.00 0.41 ? 394 LEU A CA  1 
ATOM 3024 C C   . LEU A 1 394 ? 56.304 65.843 51.861 1.00 0.41 ? 394 LEU A C   1 
ATOM 3025 O O   . LEU A 1 394 ? 55.571 66.221 52.773 1.00 0.41 ? 394 LEU A O   1 
ATOM 3026 C CB  . LEU A 1 394 ? 55.405 67.682 50.322 1.00 0.41 ? 394 LEU A CB  1 
ATOM 3027 C CG  . LEU A 1 394 ? 55.746 68.868 49.387 1.00 0.41 ? 394 LEU A CG  1 
ATOM 3028 C CD1 . LEU A 1 394 ? 55.767 68.508 47.890 1.00 0.41 ? 394 LEU A CD1 1 
ATOM 3029 C CD2 . LEU A 1 394 ? 54.747 70.015 49.611 1.00 0.41 ? 394 LEU A CD2 1 
ATOM 3030 N N   . LEU A 1 395 ? 56.947 64.659 51.950 1.00 0.53 ? 395 LEU A N   1 
ATOM 3031 C CA  . LEU A 1 395 ? 56.881 63.774 53.097 1.00 0.53 ? 395 LEU A CA  1 
ATOM 3032 C C   . LEU A 1 395 ? 57.473 64.423 54.355 1.00 0.53 ? 395 LEU A C   1 
ATOM 3033 O O   . LEU A 1 395 ? 58.591 64.934 54.279 1.00 0.53 ? 395 LEU A O   1 
ATOM 3034 C CB  . LEU A 1 395 ? 57.629 62.462 52.726 1.00 0.53 ? 395 LEU A CB  1 
ATOM 3035 C CG  . LEU A 1 395 ? 57.497 61.226 53.645 1.00 0.53 ? 395 LEU A CG  1 
ATOM 3036 C CD1 . LEU A 1 395 ? 57.928 59.966 52.871 1.00 0.53 ? 395 LEU A CD1 1 
ATOM 3037 C CD2 . LEU A 1 395 ? 58.311 61.289 54.949 1.00 0.53 ? 395 LEU A CD2 1 
ATOM 3038 N N   . PRO A 1 396 ? 56.846 64.435 55.533 1.00 0.57 ? 396 PRO A N   1 
ATOM 3039 C CA  . PRO A 1 396 ? 57.324 65.220 56.670 1.00 0.57 ? 396 PRO A CA  1 
ATOM 3040 C C   . PRO A 1 396 ? 58.414 64.491 57.449 1.00 0.57 ? 396 PRO A C   1 
ATOM 3041 O O   . PRO A 1 396 ? 58.224 64.180 58.619 1.00 0.57 ? 396 PRO A O   1 
ATOM 3042 C CB  . PRO A 1 396 ? 56.048 65.416 57.509 1.00 0.57 ? 396 PRO A CB  1 
ATOM 3043 C CG  . PRO A 1 396 ? 55.219 64.163 57.230 1.00 0.57 ? 396 PRO A CG  1 
ATOM 3044 C CD  . PRO A 1 396 ? 55.503 63.903 55.755 1.00 0.57 ? 396 PRO A CD  1 
ATOM 3045 N N   . ALA A 1 397 ? 59.550 64.173 56.787 1.00 0.64 ? 397 ALA A N   1 
ATOM 3046 C CA  . ALA A 1 397 ? 60.823 63.740 57.350 1.00 0.64 ? 397 ALA A CA  1 
ATOM 3047 C C   . ALA A 1 397 ? 60.808 62.596 58.368 1.00 0.64 ? 397 ALA A C   1 
ATOM 3048 O O   . ALA A 1 397 ? 61.736 62.438 59.155 1.00 0.64 ? 397 ALA A O   1 
ATOM 3049 C CB  . ALA A 1 397 ? 61.562 64.981 57.878 1.00 0.64 ? 397 ALA A CB  1 
ATOM 3050 N N   . ALA A 1 398 ? 59.755 61.750 58.326 1.00 0.70 ? 398 ALA A N   1 
ATOM 3051 C CA  . ALA A 1 398 ? 59.448 60.731 59.314 1.00 0.70 ? 398 ALA A CA  1 
ATOM 3052 C C   . ALA A 1 398 ? 59.231 61.275 60.743 1.00 0.70 ? 398 ALA A C   1 
ATOM 3053 O O   . ALA A 1 398 ? 59.335 60.549 61.725 1.00 0.70 ? 398 ALA A O   1 
ATOM 3054 C CB  . ALA A 1 398 ? 60.455 59.560 59.237 1.00 0.70 ? 398 ALA A CB  1 
ATOM 3055 N N   . ASP A 1 399 ? 58.849 62.566 60.915 1.00 0.63 ? 399 ASP A N   1 
ATOM 3056 C CA  . ASP A 1 399 ? 58.670 63.200 62.216 1.00 0.63 ? 399 ASP A CA  1 
ATOM 3057 C C   . ASP A 1 399 ? 57.549 62.582 63.060 1.00 0.63 ? 399 ASP A C   1 
ATOM 3058 O O   . ASP A 1 399 ? 57.682 62.362 64.267 1.00 0.63 ? 399 ASP A O   1 
ATOM 3059 C CB  . ASP A 1 399 ? 58.436 64.729 62.048 1.00 0.63 ? 399 ASP A CB  1 
ATOM 3060 C CG  . ASP A 1 399 ? 59.724 65.504 61.785 1.00 0.63 ? 399 ASP A CG  1 
ATOM 3061 O OD1 . ASP A 1 399 ? 60.775 65.138 62.382 1.00 0.63 ? 399 ASP A OD1 1 
ATOM 3062 O OD2 . ASP A 1 399 ? 59.680 66.529 61.058 1.00 0.63 ? 399 ASP A OD2 1 
ATOM 3063 N N   . LEU A 1 400 ? 56.417 62.225 62.415 1.00 0.65 ? 400 LEU A N   1 
ATOM 3064 C CA  . LEU A 1 400 ? 55.328 61.484 63.032 1.00 0.65 ? 400 LEU A CA  1 
ATOM 3065 C C   . LEU A 1 400 ? 55.782 60.108 63.513 1.00 0.65 ? 400 LEU A C   1 
ATOM 3066 O O   . LEU A 1 400 ? 55.471 59.700 64.634 1.00 0.65 ? 400 LEU A O   1 
ATOM 3067 C CB  . LEU A 1 400 ? 54.119 61.371 62.066 1.00 0.65 ? 400 LEU A CB  1 
ATOM 3068 C CG  . LEU A 1 400 ? 52.882 60.601 62.593 1.00 0.65 ? 400 LEU A CG  1 
ATOM 3069 C CD1 . LEU A 1 400 ? 52.301 61.178 63.892 1.00 0.65 ? 400 LEU A CD1 1 
ATOM 3070 C CD2 . LEU A 1 400 ? 51.787 60.542 61.516 1.00 0.65 ? 400 LEU A CD2 1 
ATOM 3071 N N   . ASP A 1 401 ? 56.599 59.397 62.701 1.00 0.71 ? 401 ASP A N   1 
ATOM 3072 C CA  . ASP A 1 401 ? 57.251 58.150 63.046 1.00 0.71 ? 401 ASP A CA  1 
ATOM 3073 C C   . ASP A 1 401 ? 58.198 58.304 64.230 1.00 0.71 ? 401 ASP A C   1 
ATOM 3074 O O   . ASP A 1 401 ? 58.137 57.527 65.182 1.00 0.71 ? 401 ASP A O   1 
ATOM 3075 C CB  . ASP A 1 401 ? 58.012 57.589 61.821 1.00 0.71 ? 401 ASP A CB  1 
ATOM 3076 C CG  . ASP A 1 401 ? 57.033 57.386 60.682 1.00 0.71 ? 401 ASP A CG  1 
ATOM 3077 O OD1 . ASP A 1 401 ? 56.284 56.384 60.792 1.00 0.71 ? 401 ASP A OD1 1 
ATOM 3078 O OD2 . ASP A 1 401 ? 57.013 58.208 59.726 1.00 0.71 ? 401 ASP A OD2 1 
ATOM 3079 N N   . ASP A 1 402 ? 59.040 59.360 64.260 1.00 0.68 ? 402 ASP A N   1 
ATOM 3080 C CA  . ASP A 1 402 ? 59.891 59.651 65.401 1.00 0.68 ? 402 ASP A CA  1 
ATOM 3081 C C   . ASP A 1 402 ? 59.115 59.836 66.691 1.00 0.68 ? 402 ASP A C   1 
ATOM 3082 O O   . ASP A 1 402 ? 59.427 59.213 67.702 1.00 0.68 ? 402 ASP A O   1 
ATOM 3083 C CB  . ASP A 1 402 ? 60.684 60.966 65.208 1.00 0.68 ? 402 ASP A CB  1 
ATOM 3084 C CG  . ASP A 1 402 ? 61.895 60.809 64.312 1.00 0.68 ? 402 ASP A CG  1 
ATOM 3085 O OD1 . ASP A 1 402 ? 62.369 59.663 64.126 1.00 0.68 ? 402 ASP A OD1 1 
ATOM 3086 O OD2 . ASP A 1 402 ? 62.433 61.884 63.945 1.00 0.68 ? 402 ASP A OD2 1 
ATOM 3087 N N   . PHE A 1 403 ? 58.046 60.655 66.674 1.00 0.67 ? 403 PHE A N   1 
ATOM 3088 C CA  . PHE A 1 403 ? 57.162 60.852 67.805 1.00 0.67 ? 403 PHE A CA  1 
ATOM 3089 C C   . PHE A 1 403 ? 56.474 59.554 68.241 1.00 0.67 ? 403 PHE A C   1 
ATOM 3090 O O   . PHE A 1 403 ? 56.539 59.164 69.406 1.00 0.67 ? 403 PHE A O   1 
ATOM 3091 C CB  . PHE A 1 403 ? 56.110 61.941 67.424 1.00 0.67 ? 403 PHE A CB  1 
ATOM 3092 C CG  . PHE A 1 403 ? 55.001 62.125 68.436 1.00 0.67 ? 403 PHE A CG  1 
ATOM 3093 C CD1 . PHE A 1 403 ? 55.226 62.809 69.637 1.00 0.67 ? 403 PHE A CD1 1 
ATOM 3094 C CD2 . PHE A 1 403 ? 53.732 61.573 68.199 1.00 0.67 ? 403 PHE A CD2 1 
ATOM 3095 C CE1 . PHE A 1 403 ? 54.207 62.933 70.590 1.00 0.67 ? 403 PHE A CE1 1 
ATOM 3096 C CE2 . PHE A 1 403 ? 52.709 61.690 69.150 1.00 0.67 ? 403 PHE A CE2 1 
ATOM 3097 C CZ  . PHE A 1 403 ? 52.946 62.374 70.349 1.00 0.67 ? 403 PHE A CZ  1 
ATOM 3098 N N   . SER A 1 404 ? 55.835 58.821 67.306 1.00 0.72 ? 404 SER A N   1 
ATOM 3099 C CA  . SER A 1 404 ? 55.085 57.613 67.624 1.00 0.72 ? 404 SER A CA  1 
ATOM 3100 C C   . SER A 1 404 ? 55.937 56.463 68.117 1.00 0.72 ? 404 SER A C   1 
ATOM 3101 O O   . SER A 1 404 ? 55.622 55.847 69.134 1.00 0.72 ? 404 SER A O   1 
ATOM 3102 C CB  . SER A 1 404 ? 54.198 57.130 66.450 1.00 0.72 ? 404 SER A CB  1 
ATOM 3103 O OG  . SER A 1 404 ? 54.956 56.727 65.311 1.00 0.72 ? 404 SER A OG  1 
ATOM 3104 N N   . LYS A 1 405 ? 57.074 56.177 67.451 1.00 0.72 ? 405 LYS A N   1 
ATOM 3105 C CA  . LYS A 1 405 ? 58.005 55.145 67.859 1.00 0.72 ? 405 LYS A CA  1 
ATOM 3106 C C   . LYS A 1 405 ? 58.714 55.458 69.166 1.00 0.72 ? 405 LYS A C   1 
ATOM 3107 O O   . LYS A 1 405 ? 58.932 54.567 69.983 1.00 0.72 ? 405 LYS A O   1 
ATOM 3108 C CB  . LYS A 1 405 ? 59.044 54.771 66.771 1.00 0.72 ? 405 LYS A CB  1 
ATOM 3109 C CG  . LYS A 1 405 ? 58.490 53.847 65.666 1.00 0.72 ? 405 LYS A CG  1 
ATOM 3110 C CD  . LYS A 1 405 ? 57.961 54.573 64.409 1.00 0.72 ? 405 LYS A CD  1 
ATOM 3111 C CE  . LYS A 1 405 ? 57.485 53.610 63.310 1.00 0.72 ? 405 LYS A CE  1 
ATOM 3112 N NZ  . LYS A 1 405 ? 57.324 54.222 61.971 1.00 0.72 ? 405 LYS A NZ  1 
ATOM 3113 N N   . GLN A 1 406 ? 59.096 56.731 69.417 1.00 0.67 ? 406 GLN A N   1 
ATOM 3114 C CA  . GLN A 1 406 ? 59.641 57.136 70.703 1.00 0.67 ? 406 GLN A CA  1 
ATOM 3115 C C   . GLN A 1 406 ? 58.631 56.993 71.836 1.00 0.67 ? 406 GLN A C   1 
ATOM 3116 O O   . GLN A 1 406 ? 58.955 56.442 72.882 1.00 0.67 ? 406 GLN A O   1 
ATOM 3117 C CB  . GLN A 1 406 ? 60.261 58.559 70.647 1.00 0.67 ? 406 GLN A CB  1 
ATOM 3118 C CG  . GLN A 1 406 ? 61.557 58.582 69.788 1.00 0.67 ? 406 GLN A CG  1 
ATOM 3119 C CD  . GLN A 1 406 ? 62.096 59.987 69.480 1.00 0.67 ? 406 GLN A CD  1 
ATOM 3120 O OE1 . GLN A 1 406 ? 61.973 60.948 70.236 1.00 0.67 ? 406 GLN A OE1 1 
ATOM 3121 N NE2 . GLN A 1 406 ? 62.795 60.123 68.325 1.00 0.67 ? 406 GLN A NE2 1 
ATOM 3122 N N   . LEU A 1 407 ? 57.361 57.402 71.643 1.00 0.71 ? 407 LEU A N   1 
ATOM 3123 C CA  . LEU A 1 407 ? 56.307 57.138 72.611 1.00 0.71 ? 407 LEU A CA  1 
ATOM 3124 C C   . LEU A 1 407 ? 56.038 55.660 72.835 1.00 0.71 ? 407 LEU A C   1 
ATOM 3125 O O   . LEU A 1 407 ? 55.870 55.219 73.969 1.00 0.71 ? 407 LEU A O   1 
ATOM 3126 C CB  . LEU A 1 407 ? 54.971 57.803 72.205 1.00 0.71 ? 407 LEU A CB  1 
ATOM 3127 C CG  . LEU A 1 407 ? 54.721 59.173 72.863 1.00 0.71 ? 407 LEU A CG  1 
ATOM 3128 C CD1 . LEU A 1 407 ? 55.750 60.235 72.448 1.00 0.71 ? 407 LEU A CD1 1 
ATOM 3129 C CD2 . LEU A 1 407 ? 53.298 59.649 72.538 1.00 0.71 ? 407 LEU A CD2 1 
ATOM 3130 N N   . GLN A 1 408 ? 55.993 54.861 71.747 1.00 0.70 ? 408 GLN A N   1 
ATOM 3131 C CA  . GLN A 1 408 ? 55.787 53.429 71.807 1.00 0.70 ? 408 GLN A CA  1 
ATOM 3132 C C   . GLN A 1 408 ? 56.870 52.692 72.572 1.00 0.70 ? 408 GLN A C   1 
ATOM 3133 O O   . GLN A 1 408 ? 56.552 51.860 73.417 1.00 0.70 ? 408 GLN A O   1 
ATOM 3134 C CB  . GLN A 1 408 ? 55.670 52.827 70.389 1.00 0.70 ? 408 GLN A CB  1 
ATOM 3135 C CG  . GLN A 1 408 ? 55.389 51.307 70.357 1.00 0.70 ? 408 GLN A CG  1 
ATOM 3136 C CD  . GLN A 1 408 ? 55.156 50.828 68.924 1.00 0.70 ? 408 GLN A CD  1 
ATOM 3137 O OE1 . GLN A 1 408 ? 55.259 51.578 67.953 1.00 0.70 ? 408 GLN A OE1 1 
ATOM 3138 N NE2 . GLN A 1 408 ? 54.818 49.525 68.785 1.00 0.70 ? 408 GLN A NE2 1 
ATOM 3139 N N   . GLN A 1 409 ? 58.160 53.016 72.328 1.00 0.68 ? 409 GLN A N   1 
ATOM 3140 C CA  . GLN A 1 409 ? 59.284 52.502 73.098 1.00 0.68 ? 409 GLN A CA  1 
ATOM 3141 C C   . GLN A 1 409 ? 59.226 52.943 74.559 1.00 0.68 ? 409 GLN A C   1 
ATOM 3142 O O   . GLN A 1 409 ? 59.406 52.144 75.471 1.00 0.68 ? 409 GLN A O   1 
ATOM 3143 C CB  . GLN A 1 409 ? 60.634 52.885 72.427 1.00 0.68 ? 409 GLN A CB  1 
ATOM 3144 C CG  . GLN A 1 409 ? 61.879 52.109 72.945 1.00 0.68 ? 409 GLN A CG  1 
ATOM 3145 C CD  . GLN A 1 409 ? 62.481 52.672 74.239 1.00 0.68 ? 409 GLN A CD  1 
ATOM 3146 O OE1 . GLN A 1 409 ? 62.643 53.887 74.385 1.00 0.68 ? 409 GLN A OE1 1 
ATOM 3147 N NE2 . GLN A 1 409 ? 62.897 51.791 75.169 1.00 0.68 ? 409 GLN A NE2 1 
ATOM 3148 N N   . SER A 1 410 ? 58.904 54.224 74.841 1.00 0.66 ? 410 SER A N   1 
ATOM 3149 C CA  . SER A 1 410 ? 58.779 54.721 76.210 1.00 0.66 ? 410 SER A CA  1 
ATOM 3150 C C   . SER A 1 410 ? 57.693 54.071 77.045 1.00 0.66 ? 410 SER A C   1 
ATOM 3151 O O   . SER A 1 410 ? 57.889 53.788 78.224 1.00 0.66 ? 410 SER A O   1 
ATOM 3152 C CB  . SER A 1 410 ? 58.462 56.232 76.283 1.00 0.66 ? 410 SER A CB  1 
ATOM 3153 O OG  . SER A 1 410 ? 59.541 57.020 75.790 1.00 0.66 ? 410 SER A OG  1 
ATOM 3154 N N   . MET A 1 411 ? 56.486 53.845 76.483 1.00 0.61 ? 411 MET A N   1 
ATOM 3155 C CA  . MET A 1 411 ? 55.437 53.125 77.185 1.00 0.61 ? 411 MET A CA  1 
ATOM 3156 C C   . MET A 1 411 ? 55.734 51.641 77.345 1.00 0.61 ? 411 MET A C   1 
ATOM 3157 O O   . MET A 1 411 ? 55.570 51.086 78.427 1.00 0.61 ? 411 MET A O   1 
ATOM 3158 C CB  . MET A 1 411 ? 54.029 53.369 76.578 1.00 0.61 ? 411 MET A CB  1 
ATOM 3159 C CG  . MET A 1 411 ? 53.782 52.748 75.190 1.00 0.61 ? 411 MET A CG  1 
ATOM 3160 S SD  . MET A 1 411 ? 52.170 53.141 74.438 1.00 0.61 ? 411 MET A SD  1 
ATOM 3161 C CE  . MET A 1 411 ? 52.513 54.871 74.017 1.00 0.61 ? 411 MET A CE  1 
ATOM 3162 N N   . SER A 1 412 ? 56.250 50.954 76.301 1.00 0.63 ? 412 SER A N   1 
ATOM 3163 C CA  . SER A 1 412 ? 56.600 49.544 76.390 1.00 0.63 ? 412 SER A CA  1 
ATOM 3164 C C   . SER A 1 412 ? 57.731 49.277 77.370 1.00 0.63 ? 412 SER A C   1 
ATOM 3165 O O   . SER A 1 412 ? 57.696 48.269 78.064 1.00 0.63 ? 412 SER A O   1 
ATOM 3166 C CB  . SER A 1 412 ? 56.895 48.881 75.016 1.00 0.63 ? 412 SER A CB  1 
ATOM 3167 O OG  . SER A 1 412 ? 57.981 49.525 74.357 1.00 0.63 ? 412 SER A OG  1 
ATOM 3168 N N   . SER A 1 413 ? 58.716 50.192 77.517 1.00 0.58 ? 413 SER A N   1 
ATOM 3169 C CA  . SER A 1 413 ? 59.782 50.062 78.506 1.00 0.58 ? 413 SER A CA  1 
ATOM 3170 C C   . SER A 1 413 ? 59.390 50.533 79.901 1.00 0.58 ? 413 SER A C   1 
ATOM 3171 O O   . SER A 1 413 ? 60.155 50.414 80.856 1.00 0.58 ? 413 SER A O   1 
ATOM 3172 C CB  . SER A 1 413 ? 61.089 50.795 78.092 1.00 0.58 ? 413 SER A CB  1 
ATOM 3173 O OG  . SER A 1 413 ? 60.977 52.222 78.082 1.00 0.58 ? 413 SER A OG  1 
ATOM 3174 N N   . ALA A 1 414 ? 58.160 51.061 80.069 1.00 0.51 ? 414 ALA A N   1 
ATOM 3175 C CA  . ALA A 1 414 ? 57.528 51.215 81.362 1.00 0.51 ? 414 ALA A CA  1 
ATOM 3176 C C   . ALA A 1 414 ? 56.722 49.972 81.739 1.00 0.51 ? 414 ALA A C   1 
ATOM 3177 O O   . ALA A 1 414 ? 56.761 49.517 82.880 1.00 0.51 ? 414 ALA A O   1 
ATOM 3178 C CB  . ALA A 1 414 ? 56.633 52.468 81.362 1.00 0.51 ? 414 ALA A CB  1 
ATOM 3179 N N   . ASP A 1 415 ? 56.002 49.374 80.761 1.00 0.45 ? 415 ASP A N   1 
ATOM 3180 C CA  . ASP A 1 415 ? 55.203 48.175 80.935 1.00 0.45 ? 415 ASP A CA  1 
ATOM 3181 C C   . ASP A 1 415 ? 56.047 46.890 81.006 1.00 0.45 ? 415 ASP A C   1 
ATOM 3182 O O   . ASP A 1 415 ? 55.600 45.842 81.474 1.00 0.45 ? 415 ASP A O   1 
ATOM 3183 C CB  . ASP A 1 415 ? 54.215 48.035 79.744 1.00 0.45 ? 415 ASP A CB  1 
ATOM 3184 C CG  . ASP A 1 415 ? 53.154 49.130 79.702 1.00 0.45 ? 415 ASP A CG  1 
ATOM 3185 O OD1 . ASP A 1 415 ? 52.934 49.817 80.729 1.00 0.45 ? 415 ASP A OD1 1 
ATOM 3186 O OD2 . ASP A 1 415 ? 52.520 49.246 78.619 1.00 0.45 ? 415 ASP A OD2 1 
ATOM 3187 N N   . SER A 1 416 ? 57.311 46.928 80.539 1.00 0.47 ? 416 SER A N   1 
ATOM 3188 C CA  . SER A 1 416 ? 58.215 45.790 80.545 1.00 0.47 ? 416 SER A CA  1 
ATOM 3189 C C   . SER A 1 416 ? 59.637 46.251 80.780 1.00 0.47 ? 416 SER A C   1 
ATOM 3190 O O   . SER A 1 416 ? 59.943 47.433 80.728 1.00 0.47 ? 416 SER A O   1 
ATOM 3191 C CB  . SER A 1 416 ? 58.126 44.882 79.277 1.00 0.47 ? 416 SER A CB  1 
ATOM 3192 O OG  . SER A 1 416 ? 58.826 45.373 78.129 1.00 0.47 ? 416 SER A OG  1 
ATOM 3193 N N   . THR A 1 417 ? 60.557 45.328 81.111 1.00 0.44 ? 417 THR A N   1 
ATOM 3194 C CA  . THR A 1 417 ? 61.915 45.680 81.522 1.00 0.44 ? 417 THR A CA  1 
ATOM 3195 C C   . THR A 1 417 ? 62.855 46.302 80.495 1.00 0.44 ? 417 THR A C   1 
ATOM 3196 O O   . THR A 1 417 ? 63.589 47.224 80.841 1.00 0.44 ? 417 THR A O   1 
ATOM 3197 C CB  . THR A 1 417 ? 62.667 44.477 82.075 1.00 0.44 ? 417 THR A CB  1 
ATOM 3198 O OG1 . THR A 1 417 ? 62.581 43.368 81.188 1.00 0.44 ? 417 THR A OG1 1 
ATOM 3199 C CG2 . THR A 1 417 ? 62.032 44.026 83.392 1.00 0.44 ? 417 THR A CG2 1 
ATOM 3200 N N   . GLN A 1 418 ? 62.922 45.774 79.253 1.00 0.57 ? 418 GLN A N   1 
ATOM 3201 C CA  . GLN A 1 418 ? 63.984 46.130 78.316 1.00 0.57 ? 418 GLN A CA  1 
ATOM 3202 C C   . GLN A 1 418 ? 63.537 46.479 76.898 1.00 0.57 ? 418 GLN A C   1 
ATOM 3203 O O   . GLN A 1 418 ? 64.383 46.598 76.017 1.00 0.57 ? 418 GLN A O   1 
ATOM 3204 C CB  . GLN A 1 418 ? 64.955 44.929 78.137 1.00 0.57 ? 418 GLN A CB  1 
ATOM 3205 C CG  . GLN A 1 418 ? 65.736 44.484 79.390 1.00 0.57 ? 418 GLN A CG  1 
ATOM 3206 C CD  . GLN A 1 418 ? 66.724 45.548 79.861 1.00 0.57 ? 418 GLN A CD  1 
ATOM 3207 O OE1 . GLN A 1 418 ? 67.093 46.503 79.182 1.00 0.57 ? 418 GLN A OE1 1 
ATOM 3208 N NE2 . GLN A 1 418 ? 67.227 45.350 81.102 1.00 0.57 ? 418 GLN A NE2 1 
ATOM 3209 N N   . ALA A 1 419 ? 62.231 46.615 76.631 1.00 0.70 ? 419 ALA A N   1 
ATOM 3210 C CA  . ALA A 1 419 ? 61.711 46.954 75.318 1.00 0.70 ? 419 ALA A CA  1 
ATOM 3211 C C   . ALA A 1 419 ? 62.016 48.397 74.799 1.00 0.70 ? 419 ALA A C   1 
ATOM 3212 O O   . ALA A 1 419 ? 62.663 49.179 75.549 1.00 0.70 ? 419 ALA A O   1 
ATOM 3213 C CB  . ALA A 1 419 ? 60.183 46.814 75.374 1.00 0.70 ? 419 ALA A CB  1 
ATOM 3214 O OXT . ALA A 1 419 ? 61.579 48.726 73.658 1.00 0.70 ? 419 ALA A OXT 1 
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