data_8ZXN
# 
_entry.id   8ZXN 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZXN         pdb_00008zxn 10.2210/pdb8zxn/pdb 
WWPDB D_1300048572 ?            ?                   
EMDB  EMD-60545    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-16 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZXN 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-14 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of human GLUT9 apo state' 
_pdbx_database_related.db_id          EMD-60545 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 4 
_pdbx_contact_author.email              t-2438@yokohama-cu.ac.jp 
_pdbx_contact_author.name_first         Tomohiro 
_pdbx_contact_author.name_last          Nishizawa 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7463-8398 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Matsushita, D.' 1 0009-0008-2024-2767 
'Lee, Y.'        2 0000-0002-1507-805X 
'Nishizawa, T.'  3 0000-0001-7463-8398 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Cell Rep' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2211-1247 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            44 
_citation.language                  ? 
_citation.page_first                115514 
_citation.page_last                 115514 
_citation.title                     'Structural basis of urate transport by glucose transporter 9.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.celrep.2025.115514 
_citation.pdbx_database_id_PubMed   40186864 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Matsushita, D.' 1 ? 
primary 'Toyoda, Y.'     2 ? 
primary 'Lee, Y.'        3 ? 
primary 'Aoi, M.'        4 ? 
primary 'Matsuo, H.'     5 ? 
primary 'Takada, T.'     6 ? 
primary 'Nishizawa, T.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer  man 'Solute carrier family 2, facilitated glucose transporter member 9'                       59707.477 1 ? ? ? ? 
2 branched man '2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose' 424.401   1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Glucose transporter type 9,GLUT-9,Urate transporter' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNA
PTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQ
AGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVV
PAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTV
IVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTI
TLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYC
FLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRPGTENLYFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNA
PTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQ
AGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVV
PAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTV
IVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTI
TLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYC
FLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRPGTENLYFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   ARG n 
1 4   LYS n 
1 5   GLN n 
1 6   ASN n 
1 7   ARG n 
1 8   ASN n 
1 9   SER n 
1 10  LYS n 
1 11  GLU n 
1 12  LEU n 
1 13  GLY n 
1 14  LEU n 
1 15  VAL n 
1 16  PRO n 
1 17  LEU n 
1 18  THR n 
1 19  ASP n 
1 20  ASP n 
1 21  THR n 
1 22  SER n 
1 23  HIS n 
1 24  ALA n 
1 25  GLY n 
1 26  PRO n 
1 27  PRO n 
1 28  GLY n 
1 29  PRO n 
1 30  GLY n 
1 31  ARG n 
1 32  ALA n 
1 33  LEU n 
1 34  LEU n 
1 35  GLU n 
1 36  CYS n 
1 37  ASP n 
1 38  HIS n 
1 39  LEU n 
1 40  ARG n 
1 41  SER n 
1 42  GLY n 
1 43  VAL n 
1 44  PRO n 
1 45  GLY n 
1 46  GLY n 
1 47  ARG n 
1 48  ARG n 
1 49  ARG n 
1 50  LYS n 
1 51  ASP n 
1 52  TRP n 
1 53  SER n 
1 54  CYS n 
1 55  SER n 
1 56  LEU n 
1 57  LEU n 
1 58  VAL n 
1 59  ALA n 
1 60  SER n 
1 61  LEU n 
1 62  ALA n 
1 63  GLY n 
1 64  ALA n 
1 65  PHE n 
1 66  GLY n 
1 67  SER n 
1 68  SER n 
1 69  PHE n 
1 70  LEU n 
1 71  TYR n 
1 72  GLY n 
1 73  TYR n 
1 74  ASN n 
1 75  LEU n 
1 76  SER n 
1 77  VAL n 
1 78  VAL n 
1 79  ASN n 
1 80  ALA n 
1 81  PRO n 
1 82  THR n 
1 83  PRO n 
1 84  TYR n 
1 85  ILE n 
1 86  LYS n 
1 87  ALA n 
1 88  PHE n 
1 89  TYR n 
1 90  ASN n 
1 91  GLU n 
1 92  SER n 
1 93  TRP n 
1 94  GLU n 
1 95  ARG n 
1 96  ARG n 
1 97  HIS n 
1 98  GLY n 
1 99  ARG n 
1 100 PRO n 
1 101 ILE n 
1 102 ASP n 
1 103 PRO n 
1 104 ASP n 
1 105 THR n 
1 106 LEU n 
1 107 THR n 
1 108 LEU n 
1 109 LEU n 
1 110 TRP n 
1 111 SER n 
1 112 VAL n 
1 113 THR n 
1 114 VAL n 
1 115 SER n 
1 116 ILE n 
1 117 PHE n 
1 118 ALA n 
1 119 ILE n 
1 120 GLY n 
1 121 GLY n 
1 122 LEU n 
1 123 VAL n 
1 124 GLY n 
1 125 THR n 
1 126 LEU n 
1 127 ILE n 
1 128 VAL n 
1 129 LYS n 
1 130 MET n 
1 131 ILE n 
1 132 GLY n 
1 133 LYS n 
1 134 VAL n 
1 135 LEU n 
1 136 GLY n 
1 137 ARG n 
1 138 LYS n 
1 139 HIS n 
1 140 THR n 
1 141 LEU n 
1 142 LEU n 
1 143 ALA n 
1 144 ASN n 
1 145 ASN n 
1 146 GLY n 
1 147 PHE n 
1 148 ALA n 
1 149 ILE n 
1 150 SER n 
1 151 ALA n 
1 152 ALA n 
1 153 LEU n 
1 154 LEU n 
1 155 MET n 
1 156 ALA n 
1 157 CYS n 
1 158 SER n 
1 159 LEU n 
1 160 GLN n 
1 161 ALA n 
1 162 GLY n 
1 163 ALA n 
1 164 PHE n 
1 165 GLU n 
1 166 MET n 
1 167 LEU n 
1 168 ILE n 
1 169 VAL n 
1 170 GLY n 
1 171 ARG n 
1 172 PHE n 
1 173 ILE n 
1 174 MET n 
1 175 GLY n 
1 176 ILE n 
1 177 ASP n 
1 178 GLY n 
1 179 GLY n 
1 180 VAL n 
1 181 ALA n 
1 182 LEU n 
1 183 SER n 
1 184 VAL n 
1 185 LEU n 
1 186 PRO n 
1 187 MET n 
1 188 TYR n 
1 189 LEU n 
1 190 SER n 
1 191 GLU n 
1 192 ILE n 
1 193 SER n 
1 194 PRO n 
1 195 LYS n 
1 196 GLU n 
1 197 ILE n 
1 198 ARG n 
1 199 GLY n 
1 200 SER n 
1 201 LEU n 
1 202 GLY n 
1 203 GLN n 
1 204 VAL n 
1 205 THR n 
1 206 ALA n 
1 207 ILE n 
1 208 PHE n 
1 209 ILE n 
1 210 CYS n 
1 211 ILE n 
1 212 GLY n 
1 213 VAL n 
1 214 PHE n 
1 215 THR n 
1 216 GLY n 
1 217 GLN n 
1 218 LEU n 
1 219 LEU n 
1 220 GLY n 
1 221 LEU n 
1 222 PRO n 
1 223 GLU n 
1 224 LEU n 
1 225 LEU n 
1 226 GLY n 
1 227 LYS n 
1 228 GLU n 
1 229 SER n 
1 230 THR n 
1 231 TRP n 
1 232 PRO n 
1 233 TYR n 
1 234 LEU n 
1 235 PHE n 
1 236 GLY n 
1 237 VAL n 
1 238 ILE n 
1 239 VAL n 
1 240 VAL n 
1 241 PRO n 
1 242 ALA n 
1 243 VAL n 
1 244 VAL n 
1 245 GLN n 
1 246 LEU n 
1 247 LEU n 
1 248 SER n 
1 249 LEU n 
1 250 PRO n 
1 251 PHE n 
1 252 LEU n 
1 253 PRO n 
1 254 ASP n 
1 255 SER n 
1 256 PRO n 
1 257 ARG n 
1 258 TYR n 
1 259 LEU n 
1 260 LEU n 
1 261 LEU n 
1 262 GLU n 
1 263 LYS n 
1 264 HIS n 
1 265 ASN n 
1 266 GLU n 
1 267 ALA n 
1 268 ARG n 
1 269 ALA n 
1 270 VAL n 
1 271 LYS n 
1 272 ALA n 
1 273 PHE n 
1 274 GLN n 
1 275 THR n 
1 276 PHE n 
1 277 LEU n 
1 278 GLY n 
1 279 LYS n 
1 280 ALA n 
1 281 ASP n 
1 282 VAL n 
1 283 SER n 
1 284 GLN n 
1 285 GLU n 
1 286 VAL n 
1 287 GLU n 
1 288 GLU n 
1 289 VAL n 
1 290 LEU n 
1 291 ALA n 
1 292 GLU n 
1 293 SER n 
1 294 ARG n 
1 295 VAL n 
1 296 GLN n 
1 297 ARG n 
1 298 SER n 
1 299 ILE n 
1 300 ARG n 
1 301 LEU n 
1 302 VAL n 
1 303 SER n 
1 304 VAL n 
1 305 LEU n 
1 306 GLU n 
1 307 LEU n 
1 308 LEU n 
1 309 ARG n 
1 310 ALA n 
1 311 PRO n 
1 312 TYR n 
1 313 VAL n 
1 314 ARG n 
1 315 TRP n 
1 316 GLN n 
1 317 VAL n 
1 318 VAL n 
1 319 THR n 
1 320 VAL n 
1 321 ILE n 
1 322 VAL n 
1 323 THR n 
1 324 MET n 
1 325 ALA n 
1 326 CYS n 
1 327 TYR n 
1 328 GLN n 
1 329 LEU n 
1 330 CYS n 
1 331 GLY n 
1 332 LEU n 
1 333 ASN n 
1 334 ALA n 
1 335 ILE n 
1 336 TRP n 
1 337 PHE n 
1 338 TYR n 
1 339 THR n 
1 340 ASN n 
1 341 SER n 
1 342 ILE n 
1 343 PHE n 
1 344 GLY n 
1 345 LYS n 
1 346 ALA n 
1 347 GLY n 
1 348 ILE n 
1 349 PRO n 
1 350 PRO n 
1 351 ALA n 
1 352 LYS n 
1 353 ILE n 
1 354 PRO n 
1 355 TYR n 
1 356 VAL n 
1 357 THR n 
1 358 LEU n 
1 359 SER n 
1 360 THR n 
1 361 GLY n 
1 362 GLY n 
1 363 ILE n 
1 364 GLU n 
1 365 THR n 
1 366 LEU n 
1 367 ALA n 
1 368 ALA n 
1 369 VAL n 
1 370 PHE n 
1 371 SER n 
1 372 GLY n 
1 373 LEU n 
1 374 VAL n 
1 375 ILE n 
1 376 GLU n 
1 377 HIS n 
1 378 LEU n 
1 379 GLY n 
1 380 ARG n 
1 381 ARG n 
1 382 PRO n 
1 383 LEU n 
1 384 LEU n 
1 385 ILE n 
1 386 GLY n 
1 387 GLY n 
1 388 PHE n 
1 389 GLY n 
1 390 LEU n 
1 391 MET n 
1 392 GLY n 
1 393 LEU n 
1 394 PHE n 
1 395 PHE n 
1 396 GLY n 
1 397 THR n 
1 398 LEU n 
1 399 THR n 
1 400 ILE n 
1 401 THR n 
1 402 LEU n 
1 403 THR n 
1 404 LEU n 
1 405 GLN n 
1 406 ASP n 
1 407 HIS n 
1 408 ALA n 
1 409 PRO n 
1 410 TRP n 
1 411 VAL n 
1 412 PRO n 
1 413 TYR n 
1 414 LEU n 
1 415 SER n 
1 416 ILE n 
1 417 VAL n 
1 418 GLY n 
1 419 ILE n 
1 420 LEU n 
1 421 ALA n 
1 422 ILE n 
1 423 ILE n 
1 424 ALA n 
1 425 SER n 
1 426 PHE n 
1 427 CYS n 
1 428 SER n 
1 429 GLY n 
1 430 PRO n 
1 431 GLY n 
1 432 GLY n 
1 433 ILE n 
1 434 PRO n 
1 435 PHE n 
1 436 ILE n 
1 437 LEU n 
1 438 THR n 
1 439 GLY n 
1 440 GLU n 
1 441 PHE n 
1 442 PHE n 
1 443 GLN n 
1 444 GLN n 
1 445 SER n 
1 446 GLN n 
1 447 ARG n 
1 448 PRO n 
1 449 ALA n 
1 450 ALA n 
1 451 PHE n 
1 452 ILE n 
1 453 ILE n 
1 454 ALA n 
1 455 GLY n 
1 456 THR n 
1 457 VAL n 
1 458 ASN n 
1 459 TRP n 
1 460 LEU n 
1 461 SER n 
1 462 ASN n 
1 463 PHE n 
1 464 ALA n 
1 465 VAL n 
1 466 GLY n 
1 467 LEU n 
1 468 LEU n 
1 469 PHE n 
1 470 PRO n 
1 471 PHE n 
1 472 ILE n 
1 473 GLN n 
1 474 LYS n 
1 475 SER n 
1 476 LEU n 
1 477 ASP n 
1 478 THR n 
1 479 TYR n 
1 480 CYS n 
1 481 PHE n 
1 482 LEU n 
1 483 VAL n 
1 484 PHE n 
1 485 ALA n 
1 486 THR n 
1 487 ILE n 
1 488 CYS n 
1 489 ILE n 
1 490 THR n 
1 491 GLY n 
1 492 ALA n 
1 493 ILE n 
1 494 TYR n 
1 495 LEU n 
1 496 TYR n 
1 497 PHE n 
1 498 VAL n 
1 499 LEU n 
1 500 PRO n 
1 501 GLU n 
1 502 THR n 
1 503 LYS n 
1 504 ASN n 
1 505 ARG n 
1 506 THR n 
1 507 TYR n 
1 508 ALA n 
1 509 GLU n 
1 510 ILE n 
1 511 SER n 
1 512 GLN n 
1 513 ALA n 
1 514 PHE n 
1 515 SER n 
1 516 LYS n 
1 517 ARG n 
1 518 ASN n 
1 519 LYS n 
1 520 ALA n 
1 521 TYR n 
1 522 PRO n 
1 523 PRO n 
1 524 GLU n 
1 525 GLU n 
1 526 LYS n 
1 527 ILE n 
1 528 ASP n 
1 529 SER n 
1 530 ALA n 
1 531 VAL n 
1 532 THR n 
1 533 ASP n 
1 534 GLY n 
1 535 LYS n 
1 536 ILE n 
1 537 ASN n 
1 538 GLY n 
1 539 ARG n 
1 540 PRO n 
1 541 GLY n 
1 542 THR n 
1 543 GLU n 
1 544 ASN n 
1 545 LEU n 
1 546 TYR n 
1 547 PHE n 
1 548 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   548 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SLC2A9, GLUT9' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            HEK293F 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_branch.entity_id   2 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 2 DGlcpNAcb1-4DGlcpNAcb1-ROH                            'Glycam Condensed Sequence' GMML       1.0   
2 2 'WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1' WURCS                       PDB2Glycan 1.1.0 
3 2 '[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}'       LINUCS                      PDB-CARE   ?     
# 
_pdbx_entity_branch_link.link_id                    1 
_pdbx_entity_branch_link.entity_id                  2 
_pdbx_entity_branch_link.entity_branch_list_num_1   2 
_pdbx_entity_branch_link.comp_id_1                  NAG 
_pdbx_entity_branch_link.atom_id_1                  C1 
_pdbx_entity_branch_link.leaving_atom_id_1          O1 
_pdbx_entity_branch_link.entity_branch_list_num_2   1 
_pdbx_entity_branch_link.comp_id_2                  NAG 
_pdbx_entity_branch_link.atom_id_2                  O4 
_pdbx_entity_branch_link.leaving_atom_id_2          HO4 
_pdbx_entity_branch_link.value_order                sing 
_pdbx_entity_branch_link.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   ARG 3   3   ?   ?   ?   A . n 
A 1 4   LYS 4   4   ?   ?   ?   A . n 
A 1 5   GLN 5   5   ?   ?   ?   A . n 
A 1 6   ASN 6   6   ?   ?   ?   A . n 
A 1 7   ARG 7   7   ?   ?   ?   A . n 
A 1 8   ASN 8   8   ?   ?   ?   A . n 
A 1 9   SER 9   9   ?   ?   ?   A . n 
A 1 10  LYS 10  10  ?   ?   ?   A . n 
A 1 11  GLU 11  11  ?   ?   ?   A . n 
A 1 12  LEU 12  12  ?   ?   ?   A . n 
A 1 13  GLY 13  13  ?   ?   ?   A . n 
A 1 14  LEU 14  14  ?   ?   ?   A . n 
A 1 15  VAL 15  15  ?   ?   ?   A . n 
A 1 16  PRO 16  16  ?   ?   ?   A . n 
A 1 17  LEU 17  17  ?   ?   ?   A . n 
A 1 18  THR 18  18  ?   ?   ?   A . n 
A 1 19  ASP 19  19  ?   ?   ?   A . n 
A 1 20  ASP 20  20  ?   ?   ?   A . n 
A 1 21  THR 21  21  ?   ?   ?   A . n 
A 1 22  SER 22  22  ?   ?   ?   A . n 
A 1 23  HIS 23  23  ?   ?   ?   A . n 
A 1 24  ALA 24  24  ?   ?   ?   A . n 
A 1 25  GLY 25  25  ?   ?   ?   A . n 
A 1 26  PRO 26  26  ?   ?   ?   A . n 
A 1 27  PRO 27  27  ?   ?   ?   A . n 
A 1 28  GLY 28  28  ?   ?   ?   A . n 
A 1 29  PRO 29  29  ?   ?   ?   A . n 
A 1 30  GLY 30  30  ?   ?   ?   A . n 
A 1 31  ARG 31  31  ?   ?   ?   A . n 
A 1 32  ALA 32  32  ?   ?   ?   A . n 
A 1 33  LEU 33  33  ?   ?   ?   A . n 
A 1 34  LEU 34  34  ?   ?   ?   A . n 
A 1 35  GLU 35  35  ?   ?   ?   A . n 
A 1 36  CYS 36  36  ?   ?   ?   A . n 
A 1 37  ASP 37  37  ?   ?   ?   A . n 
A 1 38  HIS 38  38  ?   ?   ?   A . n 
A 1 39  LEU 39  39  ?   ?   ?   A . n 
A 1 40  ARG 40  40  ?   ?   ?   A . n 
A 1 41  SER 41  41  ?   ?   ?   A . n 
A 1 42  GLY 42  42  ?   ?   ?   A . n 
A 1 43  VAL 43  43  ?   ?   ?   A . n 
A 1 44  PRO 44  44  ?   ?   ?   A . n 
A 1 45  GLY 45  45  ?   ?   ?   A . n 
A 1 46  GLY 46  46  ?   ?   ?   A . n 
A 1 47  ARG 47  47  ?   ?   ?   A . n 
A 1 48  ARG 48  48  ?   ?   ?   A . n 
A 1 49  ARG 49  49  ?   ?   ?   A . n 
A 1 50  LYS 50  50  ?   ?   ?   A . n 
A 1 51  ASP 51  51  ?   ?   ?   A . n 
A 1 52  TRP 52  52  52  TRP TRP A . n 
A 1 53  SER 53  53  53  SER SER A . n 
A 1 54  CYS 54  54  54  CYS CYS A . n 
A 1 55  SER 55  55  55  SER SER A . n 
A 1 56  LEU 56  56  56  LEU LEU A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  VAL 58  58  58  VAL VAL A . n 
A 1 59  ALA 59  59  59  ALA ALA A . n 
A 1 60  SER 60  60  60  SER SER A . n 
A 1 61  LEU 61  61  61  LEU LEU A . n 
A 1 62  ALA 62  62  62  ALA ALA A . n 
A 1 63  GLY 63  63  63  GLY GLY A . n 
A 1 64  ALA 64  64  64  ALA ALA A . n 
A 1 65  PHE 65  65  65  PHE PHE A . n 
A 1 66  GLY 66  66  66  GLY GLY A . n 
A 1 67  SER 67  67  67  SER SER A . n 
A 1 68  SER 68  68  68  SER SER A . n 
A 1 69  PHE 69  69  69  PHE PHE A . n 
A 1 70  LEU 70  70  70  LEU LEU A . n 
A 1 71  TYR 71  71  71  TYR TYR A . n 
A 1 72  GLY 72  72  72  GLY GLY A . n 
A 1 73  TYR 73  73  73  TYR TYR A . n 
A 1 74  ASN 74  74  74  ASN ASN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  SER 76  76  76  SER SER A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  VAL 78  78  78  VAL VAL A . n 
A 1 79  ASN 79  79  79  ASN ASN A . n 
A 1 80  ALA 80  80  80  ALA ALA A . n 
A 1 81  PRO 81  81  81  PRO PRO A . n 
A 1 82  THR 82  82  82  THR THR A . n 
A 1 83  PRO 83  83  83  PRO PRO A . n 
A 1 84  TYR 84  84  84  TYR TYR A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  LYS 86  86  86  LYS LYS A . n 
A 1 87  ALA 87  87  87  ALA ALA A . n 
A 1 88  PHE 88  88  88  PHE PHE A . n 
A 1 89  TYR 89  89  89  TYR TYR A . n 
A 1 90  ASN 90  90  90  ASN ASN A . n 
A 1 91  GLU 91  91  91  GLU GLU A . n 
A 1 92  SER 92  92  92  SER SER A . n 
A 1 93  TRP 93  93  93  TRP TRP A . n 
A 1 94  GLU 94  94  94  GLU GLU A . n 
A 1 95  ARG 95  95  95  ARG ARG A . n 
A 1 96  ARG 96  96  96  ARG ARG A . n 
A 1 97  HIS 97  97  97  HIS HIS A . n 
A 1 98  GLY 98  98  98  GLY GLY A . n 
A 1 99  ARG 99  99  99  ARG ARG A . n 
A 1 100 PRO 100 100 100 PRO PRO A . n 
A 1 101 ILE 101 101 101 ILE ILE A . n 
A 1 102 ASP 102 102 102 ASP ASP A . n 
A 1 103 PRO 103 103 103 PRO PRO A . n 
A 1 104 ASP 104 104 104 ASP ASP A . n 
A 1 105 THR 105 105 105 THR THR A . n 
A 1 106 LEU 106 106 106 LEU LEU A . n 
A 1 107 THR 107 107 107 THR THR A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 TRP 110 110 110 TRP TRP A . n 
A 1 111 SER 111 111 111 SER SER A . n 
A 1 112 VAL 112 112 112 VAL VAL A . n 
A 1 113 THR 113 113 113 THR THR A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 SER 115 115 115 SER SER A . n 
A 1 116 ILE 116 116 116 ILE ILE A . n 
A 1 117 PHE 117 117 117 PHE PHE A . n 
A 1 118 ALA 118 118 118 ALA ALA A . n 
A 1 119 ILE 119 119 119 ILE ILE A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 GLY 121 121 121 GLY GLY A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 VAL 123 123 123 VAL VAL A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 THR 125 125 125 THR THR A . n 
A 1 126 LEU 126 126 126 LEU LEU A . n 
A 1 127 ILE 127 127 127 ILE ILE A . n 
A 1 128 VAL 128 128 128 VAL VAL A . n 
A 1 129 LYS 129 129 129 LYS LYS A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ILE 131 131 131 ILE ILE A . n 
A 1 132 GLY 132 132 132 GLY GLY A . n 
A 1 133 LYS 133 133 133 LYS LYS A . n 
A 1 134 VAL 134 134 134 VAL VAL A . n 
A 1 135 LEU 135 135 135 LEU LEU A . n 
A 1 136 GLY 136 136 136 GLY GLY A . n 
A 1 137 ARG 137 137 137 ARG ARG A . n 
A 1 138 LYS 138 138 138 LYS LYS A . n 
A 1 139 HIS 139 139 139 HIS HIS A . n 
A 1 140 THR 140 140 140 THR THR A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 LEU 142 142 142 LEU LEU A . n 
A 1 143 ALA 143 143 143 ALA ALA A . n 
A 1 144 ASN 144 144 144 ASN ASN A . n 
A 1 145 ASN 145 145 145 ASN ASN A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 PHE 147 147 147 PHE PHE A . n 
A 1 148 ALA 148 148 148 ALA ALA A . n 
A 1 149 ILE 149 149 149 ILE ILE A . n 
A 1 150 SER 150 150 150 SER SER A . n 
A 1 151 ALA 151 151 151 ALA ALA A . n 
A 1 152 ALA 152 152 152 ALA ALA A . n 
A 1 153 LEU 153 153 153 LEU LEU A . n 
A 1 154 LEU 154 154 154 LEU LEU A . n 
A 1 155 MET 155 155 155 MET MET A . n 
A 1 156 ALA 156 156 156 ALA ALA A . n 
A 1 157 CYS 157 157 157 CYS CYS A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 LEU 159 159 159 LEU LEU A . n 
A 1 160 GLN 160 160 160 GLN GLN A . n 
A 1 161 ALA 161 161 161 ALA ALA A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 ALA 163 163 163 ALA ALA A . n 
A 1 164 PHE 164 164 164 PHE PHE A . n 
A 1 165 GLU 165 165 165 GLU GLU A . n 
A 1 166 MET 166 166 166 MET MET A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 ILE 168 168 168 ILE ILE A . n 
A 1 169 VAL 169 169 169 VAL VAL A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 ARG 171 171 171 ARG ARG A . n 
A 1 172 PHE 172 172 172 PHE PHE A . n 
A 1 173 ILE 173 173 173 ILE ILE A . n 
A 1 174 MET 174 174 174 MET MET A . n 
A 1 175 GLY 175 175 175 GLY GLY A . n 
A 1 176 ILE 176 176 176 ILE ILE A . n 
A 1 177 ASP 177 177 177 ASP ASP A . n 
A 1 178 GLY 178 178 178 GLY GLY A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 VAL 180 180 180 VAL VAL A . n 
A 1 181 ALA 181 181 181 ALA ALA A . n 
A 1 182 LEU 182 182 182 LEU LEU A . n 
A 1 183 SER 183 183 183 SER SER A . n 
A 1 184 VAL 184 184 184 VAL VAL A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 PRO 186 186 186 PRO PRO A . n 
A 1 187 MET 187 187 187 MET MET A . n 
A 1 188 TYR 188 188 188 TYR TYR A . n 
A 1 189 LEU 189 189 189 LEU LEU A . n 
A 1 190 SER 190 190 190 SER SER A . n 
A 1 191 GLU 191 191 191 GLU GLU A . n 
A 1 192 ILE 192 192 192 ILE ILE A . n 
A 1 193 SER 193 193 193 SER SER A . n 
A 1 194 PRO 194 194 194 PRO PRO A . n 
A 1 195 LYS 195 195 195 LYS LYS A . n 
A 1 196 GLU 196 196 196 GLU GLU A . n 
A 1 197 ILE 197 197 197 ILE ILE A . n 
A 1 198 ARG 198 198 198 ARG ARG A . n 
A 1 199 GLY 199 199 199 GLY GLY A . n 
A 1 200 SER 200 200 200 SER SER A . n 
A 1 201 LEU 201 201 201 LEU LEU A . n 
A 1 202 GLY 202 202 202 GLY GLY A . n 
A 1 203 GLN 203 203 203 GLN GLN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 THR 205 205 205 THR THR A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 ILE 207 207 207 ILE ILE A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 ILE 209 209 209 ILE ILE A . n 
A 1 210 CYS 210 210 210 CYS CYS A . n 
A 1 211 ILE 211 211 211 ILE ILE A . n 
A 1 212 GLY 212 212 212 GLY GLY A . n 
A 1 213 VAL 213 213 213 VAL VAL A . n 
A 1 214 PHE 214 214 214 PHE PHE A . n 
A 1 215 THR 215 215 215 THR THR A . n 
A 1 216 GLY 216 216 216 GLY GLY A . n 
A 1 217 GLN 217 217 217 GLN GLN A . n 
A 1 218 LEU 218 218 218 LEU LEU A . n 
A 1 219 LEU 219 219 219 LEU LEU A . n 
A 1 220 GLY 220 220 220 GLY GLY A . n 
A 1 221 LEU 221 221 221 LEU LEU A . n 
A 1 222 PRO 222 222 222 PRO PRO A . n 
A 1 223 GLU 223 223 223 GLU GLU A . n 
A 1 224 LEU 224 224 224 LEU LEU A . n 
A 1 225 LEU 225 225 225 LEU LEU A . n 
A 1 226 GLY 226 226 226 GLY GLY A . n 
A 1 227 LYS 227 227 227 LYS LYS A . n 
A 1 228 GLU 228 228 228 GLU GLU A . n 
A 1 229 SER 229 229 229 SER SER A . n 
A 1 230 THR 230 230 230 THR THR A . n 
A 1 231 TRP 231 231 231 TRP TRP A . n 
A 1 232 PRO 232 232 232 PRO PRO A . n 
A 1 233 TYR 233 233 233 TYR TYR A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 PHE 235 235 235 PHE PHE A . n 
A 1 236 GLY 236 236 236 GLY GLY A . n 
A 1 237 VAL 237 237 237 VAL VAL A . n 
A 1 238 ILE 238 238 238 ILE ILE A . n 
A 1 239 VAL 239 239 239 VAL VAL A . n 
A 1 240 VAL 240 240 240 VAL VAL A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 ALA 242 242 242 ALA ALA A . n 
A 1 243 VAL 243 243 243 VAL VAL A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 GLN 245 245 245 GLN GLN A . n 
A 1 246 LEU 246 246 246 LEU LEU A . n 
A 1 247 LEU 247 247 247 LEU LEU A . n 
A 1 248 SER 248 248 248 SER SER A . n 
A 1 249 LEU 249 249 249 LEU LEU A . n 
A 1 250 PRO 250 250 250 PRO PRO A . n 
A 1 251 PHE 251 251 251 PHE PHE A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 PRO 253 253 253 PRO PRO A . n 
A 1 254 ASP 254 254 254 ASP ASP A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 PRO 256 256 256 PRO PRO A . n 
A 1 257 ARG 257 257 257 ARG ARG A . n 
A 1 258 TYR 258 258 258 TYR TYR A . n 
A 1 259 LEU 259 259 259 LEU LEU A . n 
A 1 260 LEU 260 260 260 LEU LEU A . n 
A 1 261 LEU 261 261 261 LEU LEU A . n 
A 1 262 GLU 262 262 262 GLU GLU A . n 
A 1 263 LYS 263 263 263 LYS LYS A . n 
A 1 264 HIS 264 264 264 HIS HIS A . n 
A 1 265 ASN 265 265 265 ASN ASN A . n 
A 1 266 GLU 266 266 266 GLU GLU A . n 
A 1 267 ALA 267 267 267 ALA ALA A . n 
A 1 268 ARG 268 268 268 ARG ARG A . n 
A 1 269 ALA 269 269 269 ALA ALA A . n 
A 1 270 VAL 270 270 270 VAL VAL A . n 
A 1 271 LYS 271 271 271 LYS LYS A . n 
A 1 272 ALA 272 272 272 ALA ALA A . n 
A 1 273 PHE 273 273 273 PHE PHE A . n 
A 1 274 GLN 274 274 274 GLN GLN A . n 
A 1 275 THR 275 275 275 THR THR A . n 
A 1 276 PHE 276 276 276 PHE PHE A . n 
A 1 277 LEU 277 277 277 LEU LEU A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 LYS 279 279 279 LYS LYS A . n 
A 1 280 ALA 280 280 280 ALA ALA A . n 
A 1 281 ASP 281 281 281 ASP ASP A . n 
A 1 282 VAL 282 282 282 VAL VAL A . n 
A 1 283 SER 283 283 283 SER SER A . n 
A 1 284 GLN 284 284 284 GLN GLN A . n 
A 1 285 GLU 285 285 285 GLU GLU A . n 
A 1 286 VAL 286 286 286 VAL VAL A . n 
A 1 287 GLU 287 287 287 GLU GLU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 VAL 289 289 289 VAL VAL A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 ALA 291 291 291 ALA ALA A . n 
A 1 292 GLU 292 292 292 GLU GLU A . n 
A 1 293 SER 293 293 293 SER SER A . n 
A 1 294 ARG 294 294 294 ARG ARG A . n 
A 1 295 VAL 295 295 295 VAL VAL A . n 
A 1 296 GLN 296 296 296 GLN GLN A . n 
A 1 297 ARG 297 297 297 ARG ARG A . n 
A 1 298 SER 298 298 298 SER SER A . n 
A 1 299 ILE 299 299 299 ILE ILE A . n 
A 1 300 ARG 300 300 300 ARG ARG A . n 
A 1 301 LEU 301 301 301 LEU LEU A . n 
A 1 302 VAL 302 302 302 VAL VAL A . n 
A 1 303 SER 303 303 303 SER SER A . n 
A 1 304 VAL 304 304 304 VAL VAL A . n 
A 1 305 LEU 305 305 305 LEU LEU A . n 
A 1 306 GLU 306 306 306 GLU GLU A . n 
A 1 307 LEU 307 307 307 LEU LEU A . n 
A 1 308 LEU 308 308 308 LEU LEU A . n 
A 1 309 ARG 309 309 309 ARG ARG A . n 
A 1 310 ALA 310 310 310 ALA ALA A . n 
A 1 311 PRO 311 311 311 PRO PRO A . n 
A 1 312 TYR 312 312 312 TYR TYR A . n 
A 1 313 VAL 313 313 313 VAL VAL A . n 
A 1 314 ARG 314 314 314 ARG ARG A . n 
A 1 315 TRP 315 315 315 TRP TRP A . n 
A 1 316 GLN 316 316 316 GLN GLN A . n 
A 1 317 VAL 317 317 317 VAL VAL A . n 
A 1 318 VAL 318 318 318 VAL VAL A . n 
A 1 319 THR 319 319 319 THR THR A . n 
A 1 320 VAL 320 320 320 VAL VAL A . n 
A 1 321 ILE 321 321 321 ILE ILE A . n 
A 1 322 VAL 322 322 322 VAL VAL A . n 
A 1 323 THR 323 323 323 THR THR A . n 
A 1 324 MET 324 324 324 MET MET A . n 
A 1 325 ALA 325 325 325 ALA ALA A . n 
A 1 326 CYS 326 326 326 CYS CYS A . n 
A 1 327 TYR 327 327 327 TYR TYR A . n 
A 1 328 GLN 328 328 328 GLN GLN A . n 
A 1 329 LEU 329 329 329 LEU LEU A . n 
A 1 330 CYS 330 330 330 CYS CYS A . n 
A 1 331 GLY 331 331 331 GLY GLY A . n 
A 1 332 LEU 332 332 332 LEU LEU A . n 
A 1 333 ASN 333 333 333 ASN ASN A . n 
A 1 334 ALA 334 334 334 ALA ALA A . n 
A 1 335 ILE 335 335 335 ILE ILE A . n 
A 1 336 TRP 336 336 336 TRP TRP A . n 
A 1 337 PHE 337 337 337 PHE PHE A . n 
A 1 338 TYR 338 338 338 TYR TYR A . n 
A 1 339 THR 339 339 339 THR THR A . n 
A 1 340 ASN 340 340 340 ASN ASN A . n 
A 1 341 SER 341 341 341 SER SER A . n 
A 1 342 ILE 342 342 342 ILE ILE A . n 
A 1 343 PHE 343 343 343 PHE PHE A . n 
A 1 344 GLY 344 344 344 GLY GLY A . n 
A 1 345 LYS 345 345 345 LYS LYS A . n 
A 1 346 ALA 346 346 346 ALA ALA A . n 
A 1 347 GLY 347 347 347 GLY GLY A . n 
A 1 348 ILE 348 348 348 ILE ILE A . n 
A 1 349 PRO 349 349 349 PRO PRO A . n 
A 1 350 PRO 350 350 350 PRO PRO A . n 
A 1 351 ALA 351 351 351 ALA ALA A . n 
A 1 352 LYS 352 352 352 LYS LYS A . n 
A 1 353 ILE 353 353 353 ILE ILE A . n 
A 1 354 PRO 354 354 354 PRO PRO A . n 
A 1 355 TYR 355 355 355 TYR TYR A . n 
A 1 356 VAL 356 356 356 VAL VAL A . n 
A 1 357 THR 357 357 357 THR THR A . n 
A 1 358 LEU 358 358 358 LEU LEU A . n 
A 1 359 SER 359 359 359 SER SER A . n 
A 1 360 THR 360 360 360 THR THR A . n 
A 1 361 GLY 361 361 361 GLY GLY A . n 
A 1 362 GLY 362 362 362 GLY GLY A . n 
A 1 363 ILE 363 363 363 ILE ILE A . n 
A 1 364 GLU 364 364 364 GLU GLU A . n 
A 1 365 THR 365 365 365 THR THR A . n 
A 1 366 LEU 366 366 366 LEU LEU A . n 
A 1 367 ALA 367 367 367 ALA ALA A . n 
A 1 368 ALA 368 368 368 ALA ALA A . n 
A 1 369 VAL 369 369 369 VAL VAL A . n 
A 1 370 PHE 370 370 370 PHE PHE A . n 
A 1 371 SER 371 371 371 SER SER A . n 
A 1 372 GLY 372 372 372 GLY GLY A . n 
A 1 373 LEU 373 373 373 LEU LEU A . n 
A 1 374 VAL 374 374 374 VAL VAL A . n 
A 1 375 ILE 375 375 375 ILE ILE A . n 
A 1 376 GLU 376 376 376 GLU GLU A . n 
A 1 377 HIS 377 377 377 HIS HIS A . n 
A 1 378 LEU 378 378 378 LEU LEU A . n 
A 1 379 GLY 379 379 379 GLY GLY A . n 
A 1 380 ARG 380 380 380 ARG ARG A . n 
A 1 381 ARG 381 381 381 ARG ARG A . n 
A 1 382 PRO 382 382 382 PRO PRO A . n 
A 1 383 LEU 383 383 383 LEU LEU A . n 
A 1 384 LEU 384 384 384 LEU LEU A . n 
A 1 385 ILE 385 385 385 ILE ILE A . n 
A 1 386 GLY 386 386 386 GLY GLY A . n 
A 1 387 GLY 387 387 387 GLY GLY A . n 
A 1 388 PHE 388 388 388 PHE PHE A . n 
A 1 389 GLY 389 389 389 GLY GLY A . n 
A 1 390 LEU 390 390 390 LEU LEU A . n 
A 1 391 MET 391 391 391 MET MET A . n 
A 1 392 GLY 392 392 392 GLY GLY A . n 
A 1 393 LEU 393 393 393 LEU LEU A . n 
A 1 394 PHE 394 394 394 PHE PHE A . n 
A 1 395 PHE 395 395 395 PHE PHE A . n 
A 1 396 GLY 396 396 396 GLY GLY A . n 
A 1 397 THR 397 397 397 THR THR A . n 
A 1 398 LEU 398 398 398 LEU LEU A . n 
A 1 399 THR 399 399 399 THR THR A . n 
A 1 400 ILE 400 400 400 ILE ILE A . n 
A 1 401 THR 401 401 401 THR THR A . n 
A 1 402 LEU 402 402 402 LEU LEU A . n 
A 1 403 THR 403 403 403 THR THR A . n 
A 1 404 LEU 404 404 404 LEU LEU A . n 
A 1 405 GLN 405 405 405 GLN GLN A . n 
A 1 406 ASP 406 406 406 ASP ASP A . n 
A 1 407 HIS 407 407 407 HIS HIS A . n 
A 1 408 ALA 408 408 408 ALA ALA A . n 
A 1 409 PRO 409 409 409 PRO PRO A . n 
A 1 410 TRP 410 410 410 TRP TRP A . n 
A 1 411 VAL 411 411 411 VAL VAL A . n 
A 1 412 PRO 412 412 412 PRO PRO A . n 
A 1 413 TYR 413 413 413 TYR TYR A . n 
A 1 414 LEU 414 414 414 LEU LEU A . n 
A 1 415 SER 415 415 415 SER SER A . n 
A 1 416 ILE 416 416 416 ILE ILE A . n 
A 1 417 VAL 417 417 417 VAL VAL A . n 
A 1 418 GLY 418 418 418 GLY GLY A . n 
A 1 419 ILE 419 419 419 ILE ILE A . n 
A 1 420 LEU 420 420 420 LEU LEU A . n 
A 1 421 ALA 421 421 421 ALA ALA A . n 
A 1 422 ILE 422 422 422 ILE ILE A . n 
A 1 423 ILE 423 423 423 ILE ILE A . n 
A 1 424 ALA 424 424 424 ALA ALA A . n 
A 1 425 SER 425 425 425 SER SER A . n 
A 1 426 PHE 426 426 426 PHE PHE A . n 
A 1 427 CYS 427 427 427 CYS CYS A . n 
A 1 428 SER 428 428 428 SER SER A . n 
A 1 429 GLY 429 429 429 GLY GLY A . n 
A 1 430 PRO 430 430 430 PRO PRO A . n 
A 1 431 GLY 431 431 431 GLY GLY A . n 
A 1 432 GLY 432 432 432 GLY GLY A . n 
A 1 433 ILE 433 433 433 ILE ILE A . n 
A 1 434 PRO 434 434 434 PRO PRO A . n 
A 1 435 PHE 435 435 435 PHE PHE A . n 
A 1 436 ILE 436 436 436 ILE ILE A . n 
A 1 437 LEU 437 437 437 LEU LEU A . n 
A 1 438 THR 438 438 438 THR THR A . n 
A 1 439 GLY 439 439 439 GLY GLY A . n 
A 1 440 GLU 440 440 440 GLU GLU A . n 
A 1 441 PHE 441 441 441 PHE PHE A . n 
A 1 442 PHE 442 442 442 PHE PHE A . n 
A 1 443 GLN 443 443 443 GLN GLN A . n 
A 1 444 GLN 444 444 444 GLN GLN A . n 
A 1 445 SER 445 445 445 SER SER A . n 
A 1 446 GLN 446 446 446 GLN GLN A . n 
A 1 447 ARG 447 447 447 ARG ARG A . n 
A 1 448 PRO 448 448 448 PRO PRO A . n 
A 1 449 ALA 449 449 449 ALA ALA A . n 
A 1 450 ALA 450 450 450 ALA ALA A . n 
A 1 451 PHE 451 451 451 PHE PHE A . n 
A 1 452 ILE 452 452 452 ILE ILE A . n 
A 1 453 ILE 453 453 453 ILE ILE A . n 
A 1 454 ALA 454 454 454 ALA ALA A . n 
A 1 455 GLY 455 455 455 GLY GLY A . n 
A 1 456 THR 456 456 456 THR THR A . n 
A 1 457 VAL 457 457 457 VAL VAL A . n 
A 1 458 ASN 458 458 458 ASN ASN A . n 
A 1 459 TRP 459 459 459 TRP TRP A . n 
A 1 460 LEU 460 460 460 LEU LEU A . n 
A 1 461 SER 461 461 461 SER SER A . n 
A 1 462 ASN 462 462 462 ASN ASN A . n 
A 1 463 PHE 463 463 463 PHE PHE A . n 
A 1 464 ALA 464 464 464 ALA ALA A . n 
A 1 465 VAL 465 465 465 VAL VAL A . n 
A 1 466 GLY 466 466 466 GLY GLY A . n 
A 1 467 LEU 467 467 467 LEU LEU A . n 
A 1 468 LEU 468 468 468 LEU LEU A . n 
A 1 469 PHE 469 469 469 PHE PHE A . n 
A 1 470 PRO 470 470 470 PRO PRO A . n 
A 1 471 PHE 471 471 471 PHE PHE A . n 
A 1 472 ILE 472 472 472 ILE ILE A . n 
A 1 473 GLN 473 473 473 GLN GLN A . n 
A 1 474 LYS 474 474 474 LYS LYS A . n 
A 1 475 SER 475 475 475 SER SER A . n 
A 1 476 LEU 476 476 476 LEU LEU A . n 
A 1 477 ASP 477 477 477 ASP ASP A . n 
A 1 478 THR 478 478 478 THR THR A . n 
A 1 479 TYR 479 479 479 TYR TYR A . n 
A 1 480 CYS 480 480 480 CYS CYS A . n 
A 1 481 PHE 481 481 481 PHE PHE A . n 
A 1 482 LEU 482 482 482 LEU LEU A . n 
A 1 483 VAL 483 483 483 VAL VAL A . n 
A 1 484 PHE 484 484 484 PHE PHE A . n 
A 1 485 ALA 485 485 485 ALA ALA A . n 
A 1 486 THR 486 486 486 THR THR A . n 
A 1 487 ILE 487 487 487 ILE ILE A . n 
A 1 488 CYS 488 488 488 CYS CYS A . n 
A 1 489 ILE 489 489 489 ILE ILE A . n 
A 1 490 THR 490 490 490 THR THR A . n 
A 1 491 GLY 491 491 491 GLY GLY A . n 
A 1 492 ALA 492 492 492 ALA ALA A . n 
A 1 493 ILE 493 493 493 ILE ILE A . n 
A 1 494 TYR 494 494 494 TYR TYR A . n 
A 1 495 LEU 495 495 495 LEU LEU A . n 
A 1 496 TYR 496 496 496 TYR TYR A . n 
A 1 497 PHE 497 497 497 PHE PHE A . n 
A 1 498 VAL 498 498 498 VAL VAL A . n 
A 1 499 LEU 499 499 499 LEU LEU A . n 
A 1 500 PRO 500 500 500 PRO PRO A . n 
A 1 501 GLU 501 501 501 GLU GLU A . n 
A 1 502 THR 502 502 502 THR THR A . n 
A 1 503 LYS 503 503 503 LYS LYS A . n 
A 1 504 ASN 504 504 504 ASN ASN A . n 
A 1 505 ARG 505 505 505 ARG ARG A . n 
A 1 506 THR 506 506 506 THR THR A . n 
A 1 507 TYR 507 507 507 TYR TYR A . n 
A 1 508 ALA 508 508 508 ALA ALA A . n 
A 1 509 GLU 509 509 509 GLU GLU A . n 
A 1 510 ILE 510 510 510 ILE ILE A . n 
A 1 511 SER 511 511 511 SER SER A . n 
A 1 512 GLN 512 512 512 GLN GLN A . n 
A 1 513 ALA 513 513 513 ALA ALA A . n 
A 1 514 PHE 514 514 514 PHE PHE A . n 
A 1 515 SER 515 515 515 SER SER A . n 
A 1 516 LYS 516 516 516 LYS LYS A . n 
A 1 517 ARG 517 517 517 ARG ARG A . n 
A 1 518 ASN 518 518 518 ASN ASN A . n 
A 1 519 LYS 519 519 519 LYS LYS A . n 
A 1 520 ALA 520 520 520 ALA ALA A . n 
A 1 521 TYR 521 521 521 TYR TYR A . n 
A 1 522 PRO 522 522 522 PRO PRO A . n 
A 1 523 PRO 523 523 ?   ?   ?   A . n 
A 1 524 GLU 524 524 ?   ?   ?   A . n 
A 1 525 GLU 525 525 ?   ?   ?   A . n 
A 1 526 LYS 526 526 ?   ?   ?   A . n 
A 1 527 ILE 527 527 ?   ?   ?   A . n 
A 1 528 ASP 528 528 ?   ?   ?   A . n 
A 1 529 SER 529 529 ?   ?   ?   A . n 
A 1 530 ALA 530 530 ?   ?   ?   A . n 
A 1 531 VAL 531 531 ?   ?   ?   A . n 
A 1 532 THR 532 532 ?   ?   ?   A . n 
A 1 533 ASP 533 533 ?   ?   ?   A . n 
A 1 534 GLY 534 534 ?   ?   ?   A . n 
A 1 535 LYS 535 535 ?   ?   ?   A . n 
A 1 536 ILE 536 536 ?   ?   ?   A . n 
A 1 537 ASN 537 537 ?   ?   ?   A . n 
A 1 538 GLY 538 538 ?   ?   ?   A . n 
A 1 539 ARG 539 539 ?   ?   ?   A . n 
A 1 540 PRO 540 540 ?   ?   ?   A . n 
A 1 541 GLY 541 541 ?   ?   ?   A . n 
A 1 542 THR 542 542 ?   ?   ?   A . n 
A 1 543 GLU 543 543 ?   ?   ?   A . n 
A 1 544 ASN 544 544 ?   ?   ?   A . n 
A 1 545 LEU 545 545 ?   ?   ?   A . n 
A 1 546 TYR 546 546 ?   ?   ?   A . n 
A 1 547 PHE 547 547 ?   ?   ?   A . n 
A 1 548 GLN 548 548 ?   ?   ?   A . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
B 2 NAG 1 B NAG 1 A NAG 523 n 
B 2 NAG 2 B NAG 2 A NAG 524 n 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZXN 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZXN 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZXN 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               94.864 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.796 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  'HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZXN 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.06 
_refine.ls_d_res_low                             3.06 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     35766 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    100.00 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.37301 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.37301 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'PARAMETERS FOR MASK CACLULATION' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD WITH PHASES' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.481 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             9.368 
_refine.overall_SU_ML                            0.165 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'ELECTRON MICROSCOPY' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       . 
_refine_hist.d_res_low                        . 
_refine_hist.number_atoms_solvent             ? 
_refine_hist.number_atoms_total               3653 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        ? 
_refine_hist.pdbx_number_atoms_nucleic_acid   ? 
_refine_hist.pdbx_number_atoms_ligand         ? 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.006  0.011  3748  ? r_bond_refined_d             ? ? 
'ELECTRON MICROSCOPY' ? 0.000  0.016  3671  ? r_bond_other_d               ? ? 
'ELECTRON MICROSCOPY' ? 1.445  1.637  5111  ? r_angle_refined_deg          ? ? 
'ELECTRON MICROSCOPY' ? 0.439  1.555  8424  ? r_angle_other_deg            ? ? 
'ELECTRON MICROSCOPY' ? 5.918  5.000  470   ? r_dihedral_angle_1_deg       ? ? 
'ELECTRON MICROSCOPY' ? 4.825  5.000  18    ? r_dihedral_angle_2_deg       ? ? 
'ELECTRON MICROSCOPY' ? 13.592 10.000 594   ? r_dihedral_angle_3_deg       ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_dihedral_angle_4_deg       ? ? 
'ELECTRON MICROSCOPY' ? 0.071  0.200  606   ? r_chiral_restr               ? ? 
'ELECTRON MICROSCOPY' ? 0.005  0.020  4307  ? r_gen_planes_refined         ? ? 
'ELECTRON MICROSCOPY' ? 0.001  0.020  871   ? r_gen_planes_other           ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'ELECTRON MICROSCOPY' ? 9.663  8.446  1883  ? r_mcbond_it                  ? ? 
'ELECTRON MICROSCOPY' ? 9.660  8.447  1883  ? r_mcbond_other               ? ? 
'ELECTRON MICROSCOPY' ? 13.920 15.330 2352  ? r_mcangle_it                 ? ? 
'ELECTRON MICROSCOPY' ? 13.919 15.338 2353  ? r_mcangle_other              ? ? 
'ELECTRON MICROSCOPY' ? 13.490 10.351 1865  ? r_scbond_it                  ? ? 
'ELECTRON MICROSCOPY' ? 13.487 10.358 1866  ? r_scbond_other               ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'ELECTRON MICROSCOPY' ? 21.284 18.254 2760  ? r_scangle_other              ? ? 
'ELECTRON MICROSCOPY' ? 25.651 105.24 15025 ? r_long_range_B_refined       ? ? 
'ELECTRON MICROSCOPY' ? 25.651 105.25 15026 ? r_long_range_B_other         ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'ELECTRON MICROSCOPY' 
_refine_ls_shell.d_res_high                       3.100 
_refine_ls_shell.d_res_low                        3.180 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             0 
_refine_ls_shell.number_reflns_R_work             2669 
_refine_ls_shell.percent_reflns_obs               100.00 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  2.252 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.000 
# 
_struct.entry_id                     8ZXN 
_struct.title                        'Cryo-EM structure of human GLUT9 apo state' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZXN 
_struct_keywords.text            'Urate, Transporter, Hypouricemia, RHUC, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    GTR9_HUMAN 
_struct_ref.pdbx_db_accession          Q9NRM0 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNA
PTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQ
AGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVV
PAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTV
IVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTI
TLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYC
FLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8ZXN 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 540 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q9NRM0 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  540 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       540 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZXN GLY A 541 ? UNP Q9NRM0 ? ? 'expression tag' 541 1 
1 8ZXN THR A 542 ? UNP Q9NRM0 ? ? 'expression tag' 542 2 
1 8ZXN GLU A 543 ? UNP Q9NRM0 ? ? 'expression tag' 543 3 
1 8ZXN ASN A 544 ? UNP Q9NRM0 ? ? 'expression tag' 544 4 
1 8ZXN LEU A 545 ? UNP Q9NRM0 ? ? 'expression tag' 545 5 
1 8ZXN TYR A 546 ? UNP Q9NRM0 ? ? 'expression tag' 546 6 
1 8ZXN PHE A 547 ? UNP Q9NRM0 ? ? 'expression tag' 547 7 
1 8ZXN GLN A 548 ? UNP Q9NRM0 ? ? 'expression tag' 548 8 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 53  ? GLY A 66  ? SER A 53  GLY A 66  1 ? 14 
HELX_P HELX_P2  AA2 SER A 67  ? VAL A 77  ? SER A 67  VAL A 77  1 ? 11 
HELX_P HELX_P3  AA3 PRO A 81  ? GLY A 98  ? PRO A 81  GLY A 98  1 ? 18 
HELX_P HELX_P4  AA4 ASP A 102 ? GLY A 132 ? ASP A 102 GLY A 132 1 ? 31 
HELX_P HELX_P5  AA5 GLY A 136 ? ASN A 144 ? GLY A 136 ASN A 144 1 ? 9  
HELX_P HELX_P6  AA6 ASN A 144 ? CYS A 157 ? ASN A 144 CYS A 157 1 ? 14 
HELX_P HELX_P7  AA7 CYS A 157 ? GLY A 162 ? CYS A 157 GLY A 162 1 ? 6  
HELX_P HELX_P8  AA8 PHE A 164 ? SER A 193 ? PHE A 164 SER A 193 1 ? 30 
HELX_P HELX_P9  AA9 PRO A 194 ? ARG A 198 ? PRO A 194 ARG A 198 5 ? 5  
HELX_P HELX_P10 AB1 SER A 200 ? GLY A 220 ? SER A 200 GLY A 220 1 ? 21 
HELX_P HELX_P11 AB2 TRP A 231 ? VAL A 237 ? TRP A 231 VAL A 237 1 ? 7  
HELX_P HELX_P12 AB3 ILE A 238 ? LEU A 247 ? ILE A 238 LEU A 247 1 ? 10 
HELX_P HELX_P13 AB4 SER A 248 ? LEU A 252 ? SER A 248 LEU A 252 5 ? 5  
HELX_P HELX_P14 AB5 ARG A 257 ? GLU A 262 ? ARG A 257 GLU A 262 1 ? 6  
HELX_P HELX_P15 AB6 ASN A 265 ? GLY A 278 ? ASN A 265 GLY A 278 1 ? 14 
HELX_P HELX_P16 AB7 VAL A 282 ? ARG A 297 ? VAL A 282 ARG A 297 1 ? 16 
HELX_P HELX_P17 AB8 SER A 303 ? ALA A 310 ? SER A 303 ALA A 310 1 ? 8  
HELX_P HELX_P18 AB9 VAL A 313 ? CYS A 330 ? VAL A 313 CYS A 330 1 ? 18 
HELX_P HELX_P19 AC1 GLY A 331 ? ALA A 346 ? GLY A 331 ALA A 346 1 ? 16 
HELX_P HELX_P20 AC2 LYS A 352 ? GLU A 376 ? LYS A 352 GLU A 376 1 ? 25 
HELX_P HELX_P21 AC3 GLY A 379 ? LEU A 404 ? GLY A 379 LEU A 404 1 ? 26 
HELX_P HELX_P22 AC4 TRP A 410 ? SER A 428 ? TRP A 410 SER A 428 1 ? 19 
HELX_P HELX_P23 AC5 GLY A 432 ? PHE A 441 ? GLY A 432 PHE A 441 1 ? 10 
HELX_P HELX_P24 AC6 GLN A 446 ? ASP A 477 ? GLN A 446 ASP A 477 1 ? 32 
HELX_P HELX_P25 AC7 THR A 478 ? CYS A 480 ? THR A 478 CYS A 480 5 ? 3  
HELX_P HELX_P26 AC8 PHE A 481 ? LEU A 499 ? PHE A 481 LEU A 499 1 ? 19 
HELX_P HELX_P27 AC9 THR A 506 ? LYS A 519 ? THR A 506 LYS A 519 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale one  ? A ASN 90 ND2 ? ? ? 1_555 B NAG . C1 ? ? A ASN 90 B NAG 1 1_555 ? ? ? ? ? ? ? 1.447 ? N-Glycosylation 
covale2 covale both ? B NAG .  O4  ? ? ? 1_555 B NAG . C1 ? ? B NAG 1  B NAG 2 1_555 ? ? ? ? ? ? ? 1.399 ? ?               
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      NAG 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     ASN 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      90 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       NAG 
_pdbx_modification_feature.auth_asym_id                       B 
_pdbx_modification_feature.auth_seq_id                        1 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      ASN 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       90 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C1 
_pdbx_modification_feature.modified_residue_id_linking_atom   ND2 
_pdbx_modification_feature.modified_residue_id                ASN 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        NAG 
_pdbx_modification_feature.type                               N-Glycosylation 
_pdbx_modification_feature.category                           Carbohydrate 
# 
_pdbx_entry_details.entry_id                   8ZXN 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER A 67  ? ? -133.80 -69.26  
2 1 LEU A 224 ? ? -102.82 -108.31 
3 1 ASP A 477 ? ? 61.48   -105.94 
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     137 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.089 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8ZXN 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8ZXN 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.06 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               311544 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            8.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Glucose transporter 9' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8ZXN 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             1600 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8ZXN 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8ZXN 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ALA 2   ? A ALA 2   
3  1 Y 1 A ARG 3   ? A ARG 3   
4  1 Y 1 A LYS 4   ? A LYS 4   
5  1 Y 1 A GLN 5   ? A GLN 5   
6  1 Y 1 A ASN 6   ? A ASN 6   
7  1 Y 1 A ARG 7   ? A ARG 7   
8  1 Y 1 A ASN 8   ? A ASN 8   
9  1 Y 1 A SER 9   ? A SER 9   
10 1 Y 1 A LYS 10  ? A LYS 10  
11 1 Y 1 A GLU 11  ? A GLU 11  
12 1 Y 1 A LEU 12  ? A LEU 12  
13 1 Y 1 A GLY 13  ? A GLY 13  
14 1 Y 1 A LEU 14  ? A LEU 14  
15 1 Y 1 A VAL 15  ? A VAL 15  
16 1 Y 1 A PRO 16  ? A PRO 16  
17 1 Y 1 A LEU 17  ? A LEU 17  
18 1 Y 1 A THR 18  ? A THR 18  
19 1 Y 1 A ASP 19  ? A ASP 19  
20 1 Y 1 A ASP 20  ? A ASP 20  
21 1 Y 1 A THR 21  ? A THR 21  
22 1 Y 1 A SER 22  ? A SER 22  
23 1 Y 1 A HIS 23  ? A HIS 23  
24 1 Y 1 A ALA 24  ? A ALA 24  
25 1 Y 1 A GLY 25  ? A GLY 25  
26 1 Y 1 A PRO 26  ? A PRO 26  
27 1 Y 1 A PRO 27  ? A PRO 27  
28 1 Y 1 A GLY 28  ? A GLY 28  
29 1 Y 1 A PRO 29  ? A PRO 29  
30 1 Y 1 A GLY 30  ? A GLY 30  
31 1 Y 1 A ARG 31  ? A ARG 31  
32 1 Y 1 A ALA 32  ? A ALA 32  
33 1 Y 1 A LEU 33  ? A LEU 33  
34 1 Y 1 A LEU 34  ? A LEU 34  
35 1 Y 1 A GLU 35  ? A GLU 35  
36 1 Y 1 A CYS 36  ? A CYS 36  
37 1 Y 1 A ASP 37  ? A ASP 37  
38 1 Y 1 A HIS 38  ? A HIS 38  
39 1 Y 1 A LEU 39  ? A LEU 39  
40 1 Y 1 A ARG 40  ? A ARG 40  
41 1 Y 1 A SER 41  ? A SER 41  
42 1 Y 1 A GLY 42  ? A GLY 42  
43 1 Y 1 A VAL 43  ? A VAL 43  
44 1 Y 1 A PRO 44  ? A PRO 44  
45 1 Y 1 A GLY 45  ? A GLY 45  
46 1 Y 1 A GLY 46  ? A GLY 46  
47 1 Y 1 A ARG 47  ? A ARG 47  
48 1 Y 1 A ARG 48  ? A ARG 48  
49 1 Y 1 A ARG 49  ? A ARG 49  
50 1 Y 1 A LYS 50  ? A LYS 50  
51 1 Y 1 A ASP 51  ? A ASP 51  
52 1 Y 1 A PRO 523 ? A PRO 523 
53 1 Y 1 A GLU 524 ? A GLU 524 
54 1 Y 1 A GLU 525 ? A GLU 525 
55 1 Y 1 A LYS 526 ? A LYS 526 
56 1 Y 1 A ILE 527 ? A ILE 527 
57 1 Y 1 A ASP 528 ? A ASP 528 
58 1 Y 1 A SER 529 ? A SER 529 
59 1 Y 1 A ALA 530 ? A ALA 530 
60 1 Y 1 A VAL 531 ? A VAL 531 
61 1 Y 1 A THR 532 ? A THR 532 
62 1 Y 1 A ASP 533 ? A ASP 533 
63 1 Y 1 A GLY 534 ? A GLY 534 
64 1 Y 1 A LYS 535 ? A LYS 535 
65 1 Y 1 A ILE 536 ? A ILE 536 
66 1 Y 1 A ASN 537 ? A ASN 537 
67 1 Y 1 A GLY 538 ? A GLY 538 
68 1 Y 1 A ARG 539 ? A ARG 539 
69 1 Y 1 A PRO 540 ? A PRO 540 
70 1 Y 1 A GLY 541 ? A GLY 541 
71 1 Y 1 A THR 542 ? A THR 542 
72 1 Y 1 A GLU 543 ? A GLU 543 
73 1 Y 1 A ASN 544 ? A ASN 544 
74 1 Y 1 A LEU 545 ? A LEU 545 
75 1 Y 1 A TYR 546 ? A TYR 546 
76 1 Y 1 A PHE 547 ? A PHE 547 
77 1 Y 1 A GLN 548 ? A GLN 548 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
NAG C1   C N R 247 
NAG C2   C N R 248 
NAG C3   C N R 249 
NAG C4   C N S 250 
NAG C5   C N R 251 
NAG C6   C N N 252 
NAG C7   C N N 253 
NAG C8   C N N 254 
NAG N2   N N N 255 
NAG O1   O N N 256 
NAG O3   O N N 257 
NAG O4   O N N 258 
NAG O5   O N N 259 
NAG O6   O N N 260 
NAG O7   O N N 261 
NAG H1   H N N 262 
NAG H2   H N N 263 
NAG H3   H N N 264 
NAG H4   H N N 265 
NAG H5   H N N 266 
NAG H61  H N N 267 
NAG H62  H N N 268 
NAG H81  H N N 269 
NAG H82  H N N 270 
NAG H83  H N N 271 
NAG HN2  H N N 272 
NAG HO1  H N N 273 
NAG HO3  H N N 274 
NAG HO4  H N N 275 
NAG HO6  H N N 276 
PHE N    N N N 277 
PHE CA   C N S 278 
PHE C    C N N 279 
PHE O    O N N 280 
PHE CB   C N N 281 
PHE CG   C Y N 282 
PHE CD1  C Y N 283 
PHE CD2  C Y N 284 
PHE CE1  C Y N 285 
PHE CE2  C Y N 286 
PHE CZ   C Y N 287 
PHE OXT  O N N 288 
PHE H    H N N 289 
PHE H2   H N N 290 
PHE HA   H N N 291 
PHE HB2  H N N 292 
PHE HB3  H N N 293 
PHE HD1  H N N 294 
PHE HD2  H N N 295 
PHE HE1  H N N 296 
PHE HE2  H N N 297 
PHE HZ   H N N 298 
PHE HXT  H N N 299 
PRO N    N N N 300 
PRO CA   C N S 301 
PRO C    C N N 302 
PRO O    O N N 303 
PRO CB   C N N 304 
PRO CG   C N N 305 
PRO CD   C N N 306 
PRO OXT  O N N 307 
PRO H    H N N 308 
PRO HA   H N N 309 
PRO HB2  H N N 310 
PRO HB3  H N N 311 
PRO HG2  H N N 312 
PRO HG3  H N N 313 
PRO HD2  H N N 314 
PRO HD3  H N N 315 
PRO HXT  H N N 316 
SER N    N N N 317 
SER CA   C N S 318 
SER C    C N N 319 
SER O    O N N 320 
SER CB   C N N 321 
SER OG   O N N 322 
SER OXT  O N N 323 
SER H    H N N 324 
SER H2   H N N 325 
SER HA   H N N 326 
SER HB2  H N N 327 
SER HB3  H N N 328 
SER HG   H N N 329 
SER HXT  H N N 330 
THR N    N N N 331 
THR CA   C N S 332 
THR C    C N N 333 
THR O    O N N 334 
THR CB   C N R 335 
THR OG1  O N N 336 
THR CG2  C N N 337 
THR OXT  O N N 338 
THR H    H N N 339 
THR H2   H N N 340 
THR HA   H N N 341 
THR HB   H N N 342 
THR HG1  H N N 343 
THR HG21 H N N 344 
THR HG22 H N N 345 
THR HG23 H N N 346 
THR HXT  H N N 347 
TRP N    N N N 348 
TRP CA   C N S 349 
TRP C    C N N 350 
TRP O    O N N 351 
TRP CB   C N N 352 
TRP CG   C Y N 353 
TRP CD1  C Y N 354 
TRP CD2  C Y N 355 
TRP NE1  N Y N 356 
TRP CE2  C Y N 357 
TRP CE3  C Y N 358 
TRP CZ2  C Y N 359 
TRP CZ3  C Y N 360 
TRP CH2  C Y N 361 
TRP OXT  O N N 362 
TRP H    H N N 363 
TRP H2   H N N 364 
TRP HA   H N N 365 
TRP HB2  H N N 366 
TRP HB3  H N N 367 
TRP HD1  H N N 368 
TRP HE1  H N N 369 
TRP HE3  H N N 370 
TRP HZ2  H N N 371 
TRP HZ3  H N N 372 
TRP HH2  H N N 373 
TRP HXT  H N N 374 
TYR N    N N N 375 
TYR CA   C N S 376 
TYR C    C N N 377 
TYR O    O N N 378 
TYR CB   C N N 379 
TYR CG   C Y N 380 
TYR CD1  C Y N 381 
TYR CD2  C Y N 382 
TYR CE1  C Y N 383 
TYR CE2  C Y N 384 
TYR CZ   C Y N 385 
TYR OH   O N N 386 
TYR OXT  O N N 387 
TYR H    H N N 388 
TYR H2   H N N 389 
TYR HA   H N N 390 
TYR HB2  H N N 391 
TYR HB3  H N N 392 
TYR HD1  H N N 393 
TYR HD2  H N N 394 
TYR HE1  H N N 395 
TYR HE2  H N N 396 
TYR HH   H N N 397 
TYR HXT  H N N 398 
VAL N    N N N 399 
VAL CA   C N S 400 
VAL C    C N N 401 
VAL O    O N N 402 
VAL CB   C N N 403 
VAL CG1  C N N 404 
VAL CG2  C N N 405 
VAL OXT  O N N 406 
VAL H    H N N 407 
VAL H2   H N N 408 
VAL HA   H N N 409 
VAL HB   H N N 410 
VAL HG11 H N N 411 
VAL HG12 H N N 412 
VAL HG13 H N N 413 
VAL HG21 H N N 414 
VAL HG22 H N N 415 
VAL HG23 H N N 416 
VAL HXT  H N N 417 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
NAG C1  C2   sing N N 235 
NAG C1  O1   sing N N 236 
NAG C1  O5   sing N N 237 
NAG C1  H1   sing N N 238 
NAG C2  C3   sing N N 239 
NAG C2  N2   sing N N 240 
NAG C2  H2   sing N N 241 
NAG C3  C4   sing N N 242 
NAG C3  O3   sing N N 243 
NAG C3  H3   sing N N 244 
NAG C4  C5   sing N N 245 
NAG C4  O4   sing N N 246 
NAG C4  H4   sing N N 247 
NAG C5  C6   sing N N 248 
NAG C5  O5   sing N N 249 
NAG C5  H5   sing N N 250 
NAG C6  O6   sing N N 251 
NAG C6  H61  sing N N 252 
NAG C6  H62  sing N N 253 
NAG C7  C8   sing N N 254 
NAG C7  N2   sing N N 255 
NAG C7  O7   doub N N 256 
NAG C8  H81  sing N N 257 
NAG C8  H82  sing N N 258 
NAG C8  H83  sing N N 259 
NAG N2  HN2  sing N N 260 
NAG O1  HO1  sing N N 261 
NAG O3  HO3  sing N N 262 
NAG O4  HO4  sing N N 263 
NAG O6  HO6  sing N N 264 
PHE N   CA   sing N N 265 
PHE N   H    sing N N 266 
PHE N   H2   sing N N 267 
PHE CA  C    sing N N 268 
PHE CA  CB   sing N N 269 
PHE CA  HA   sing N N 270 
PHE C   O    doub N N 271 
PHE C   OXT  sing N N 272 
PHE CB  CG   sing N N 273 
PHE CB  HB2  sing N N 274 
PHE CB  HB3  sing N N 275 
PHE CG  CD1  doub Y N 276 
PHE CG  CD2  sing Y N 277 
PHE CD1 CE1  sing Y N 278 
PHE CD1 HD1  sing N N 279 
PHE CD2 CE2  doub Y N 280 
PHE CD2 HD2  sing N N 281 
PHE CE1 CZ   doub Y N 282 
PHE CE1 HE1  sing N N 283 
PHE CE2 CZ   sing Y N 284 
PHE CE2 HE2  sing N N 285 
PHE CZ  HZ   sing N N 286 
PHE OXT HXT  sing N N 287 
PRO N   CA   sing N N 288 
PRO N   CD   sing N N 289 
PRO N   H    sing N N 290 
PRO CA  C    sing N N 291 
PRO CA  CB   sing N N 292 
PRO CA  HA   sing N N 293 
PRO C   O    doub N N 294 
PRO C   OXT  sing N N 295 
PRO CB  CG   sing N N 296 
PRO CB  HB2  sing N N 297 
PRO CB  HB3  sing N N 298 
PRO CG  CD   sing N N 299 
PRO CG  HG2  sing N N 300 
PRO CG  HG3  sing N N 301 
PRO CD  HD2  sing N N 302 
PRO CD  HD3  sing N N 303 
PRO OXT HXT  sing N N 304 
SER N   CA   sing N N 305 
SER N   H    sing N N 306 
SER N   H2   sing N N 307 
SER CA  C    sing N N 308 
SER CA  CB   sing N N 309 
SER CA  HA   sing N N 310 
SER C   O    doub N N 311 
SER C   OXT  sing N N 312 
SER CB  OG   sing N N 313 
SER CB  HB2  sing N N 314 
SER CB  HB3  sing N N 315 
SER OG  HG   sing N N 316 
SER OXT HXT  sing N N 317 
THR N   CA   sing N N 318 
THR N   H    sing N N 319 
THR N   H2   sing N N 320 
THR CA  C    sing N N 321 
THR CA  CB   sing N N 322 
THR CA  HA   sing N N 323 
THR C   O    doub N N 324 
THR C   OXT  sing N N 325 
THR CB  OG1  sing N N 326 
THR CB  CG2  sing N N 327 
THR CB  HB   sing N N 328 
THR OG1 HG1  sing N N 329 
THR CG2 HG21 sing N N 330 
THR CG2 HG22 sing N N 331 
THR CG2 HG23 sing N N 332 
THR OXT HXT  sing N N 333 
TRP N   CA   sing N N 334 
TRP N   H    sing N N 335 
TRP N   H2   sing N N 336 
TRP CA  C    sing N N 337 
TRP CA  CB   sing N N 338 
TRP CA  HA   sing N N 339 
TRP C   O    doub N N 340 
TRP C   OXT  sing N N 341 
TRP CB  CG   sing N N 342 
TRP CB  HB2  sing N N 343 
TRP CB  HB3  sing N N 344 
TRP CG  CD1  doub Y N 345 
TRP CG  CD2  sing Y N 346 
TRP CD1 NE1  sing Y N 347 
TRP CD1 HD1  sing N N 348 
TRP CD2 CE2  doub Y N 349 
TRP CD2 CE3  sing Y N 350 
TRP NE1 CE2  sing Y N 351 
TRP NE1 HE1  sing N N 352 
TRP CE2 CZ2  sing Y N 353 
TRP CE3 CZ3  doub Y N 354 
TRP CE3 HE3  sing N N 355 
TRP CZ2 CH2  doub Y N 356 
TRP CZ2 HZ2  sing N N 357 
TRP CZ3 CH2  sing Y N 358 
TRP CZ3 HZ3  sing N N 359 
TRP CH2 HH2  sing N N 360 
TRP OXT HXT  sing N N 361 
TYR N   CA   sing N N 362 
TYR N   H    sing N N 363 
TYR N   H2   sing N N 364 
TYR CA  C    sing N N 365 
TYR CA  CB   sing N N 366 
TYR CA  HA   sing N N 367 
TYR C   O    doub N N 368 
TYR C   OXT  sing N N 369 
TYR CB  CG   sing N N 370 
TYR CB  HB2  sing N N 371 
TYR CB  HB3  sing N N 372 
TYR CG  CD1  doub Y N 373 
TYR CG  CD2  sing Y N 374 
TYR CD1 CE1  sing Y N 375 
TYR CD1 HD1  sing N N 376 
TYR CD2 CE2  doub Y N 377 
TYR CD2 HD2  sing N N 378 
TYR CE1 CZ   doub Y N 379 
TYR CE1 HE1  sing N N 380 
TYR CE2 CZ   sing Y N 381 
TYR CE2 HE2  sing N N 382 
TYR CZ  OH   sing N N 383 
TYR OH  HH   sing N N 384 
TYR OXT HXT  sing N N 385 
VAL N   CA   sing N N 386 
VAL N   H    sing N N 387 
VAL N   H2   sing N N 388 
VAL CA  C    sing N N 389 
VAL CA  CB   sing N N 390 
VAL CA  HA   sing N N 391 
VAL C   O    doub N N 392 
VAL C   OXT  sing N N 393 
VAL CB  CG1  sing N N 394 
VAL CB  CG2  sing N N 395 
VAL CB  HB   sing N N 396 
VAL CG1 HG11 sing N N 397 
VAL CG1 HG12 sing N N 398 
VAL CG1 HG13 sing N N 399 
VAL CG2 HG21 sing N N 400 
VAL CG2 HG22 sing N N 401 
VAL CG2 HG23 sing N N 402 
VAL OXT HXT  sing N N 403 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-06-14 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8ZXN 
_em_admin.last_update        2025-04-16 
_em_admin.map_release_date   2025-04-16 
_em_admin.title              'Cryo-EM structure of human GLUT9 apo state' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                KILODALTONS/NANOMETER 
_em_entity_assembly_molwt.value                60 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         51 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Society for the Promotion of Science (JSPS)' Japan 24K18064   1 
'Japan Society for the Promotion of Science (JSPS)' Japan 23K27132   2 
'Japan Society for the Promotion of Science (JSPS)' Japan 24H02264   3 
'Japan Science and Technology'                      Japan JPMJPR21EF 4 
'Japan Society for the Promotion of Science (JSPS)' Japan 21K15031   5 
'Japan Society for the Promotion of Science (JSPS)' Japan 20H03216   6 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
2 NAG 1 n 
2 NAG 2 n 
# 
_atom_sites.entry_id                    8ZXN 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . TRP A 1 52  ? 85.873  87.657  97.197  1.00 181.07 ? 52  TRP A N   1 
ATOM   2    C CA  . TRP A 1 52  ? 86.839  88.358  96.312  1.00 177.27 ? 52  TRP A CA  1 
ATOM   3    C C   . TRP A 1 52  ? 86.672  87.882  94.869  1.00 169.25 ? 52  TRP A C   1 
ATOM   4    O O   . TRP A 1 52  ? 87.024  86.750  94.542  1.00 165.91 ? 52  TRP A O   1 
ATOM   5    C CB  . TRP A 1 52  ? 88.284  88.139  96.787  1.00 179.81 ? 52  TRP A CB  1 
ATOM   6    C CG  . TRP A 1 52  ? 88.616  88.747  98.126  1.00 211.62 ? 52  TRP A CG  1 
ATOM   7    C CD1 . TRP A 1 52  ? 88.365  88.199  99.350  1.00 242.32 ? 52  TRP A CD1 1 
ATOM   8    C CD2 . TRP A 1 52  ? 89.266  90.016  98.380  1.00 237.84 ? 52  TRP A CD2 1 
ATOM   9    N NE1 . TRP A 1 52  ? 88.813  89.027  100.345 1.00 258.67 ? 52  TRP A NE1 1 
ATOM   10   C CE2 . TRP A 1 52  ? 89.364  90.150  99.785  1.00 262.75 ? 52  TRP A CE2 1 
ATOM   11   C CE3 . TRP A 1 52  ? 89.760  91.052  97.575  1.00 241.81 ? 52  TRP A CE3 1 
ATOM   12   C CZ2 . TRP A 1 52  ? 89.946  91.264  100.390 1.00 265.97 ? 52  TRP A CZ2 1 
ATOM   13   C CZ3 . TRP A 1 52  ? 90.335  92.155  98.174  1.00 257.42 ? 52  TRP A CZ3 1 
ATOM   14   C CH2 . TRP A 1 52  ? 90.415  92.262  99.565  1.00 256.59 ? 52  TRP A CH2 1 
ATOM   15   N N   . SER A 1 53  ? 86.138  88.769  94.017  1.00 161.93 ? 53  SER A N   1 
ATOM   16   C CA  . SER A 1 53  ? 86.137  88.576  92.574  1.00 153.86 ? 53  SER A CA  1 
ATOM   17   C C   . SER A 1 53  ? 87.537  88.822  92.011  1.00 142.81 ? 53  SER A C   1 
ATOM   18   O O   . SER A 1 53  ? 88.420  89.315  92.711  1.00 125.28 ? 53  SER A O   1 
ATOM   19   C CB  . SER A 1 53  ? 85.145  89.490  91.919  1.00 155.55 ? 53  SER A CB  1 
ATOM   20   O OG  . SER A 1 53  ? 85.554  90.841  92.059  1.00 154.94 ? 53  SER A OG  1 
ATOM   21   N N   . CYS A 1 54  ? 87.716  88.530  90.716  1.00 146.19 ? 54  CYS A N   1 
ATOM   22   C CA  . CYS A 1 54  ? 89.018  88.614  90.072  1.00 151.44 ? 54  CYS A CA  1 
ATOM   23   C C   . CYS A 1 54  ? 89.541  90.052  90.067  1.00 131.14 ? 54  CYS A C   1 
ATOM   24   O O   . CYS A 1 54  ? 90.644  90.317  90.546  1.00 134.05 ? 54  CYS A O   1 
ATOM   25   C CB  . CYS A 1 54  ? 88.950  88.079  88.645  1.00 169.63 ? 54  CYS A CB  1 
ATOM   26   S SG  . CYS A 1 54  ? 90.548  88.117  87.791  1.00 191.54 ? 54  CYS A SG  1 
ATOM   27   N N   . SER A 1 55  ? 88.741  90.984  89.532  1.00 122.39 ? 55  SER A N   1 
ATOM   28   C CA  . SER A 1 55  ? 89.186  92.350  89.285  1.00 111.38 ? 55  SER A CA  1 
ATOM   29   C C   . SER A 1 55  ? 89.410  93.138  90.579  1.00 96.02  ? 55  SER A C   1 
ATOM   30   O O   . SER A 1 55  ? 90.130  94.134  90.562  1.00 97.24  ? 55  SER A O   1 
ATOM   31   C CB  . SER A 1 55  ? 88.223  93.053  88.369  1.00 113.93 ? 55  SER A CB  1 
ATOM   32   O OG  . SER A 1 55  ? 88.109  92.355  87.134  1.00 111.75 ? 55  SER A OG  1 
ATOM   33   N N   . LEU A 1 56  ? 88.813  92.693  91.697  1.00 93.82  ? 56  LEU A N   1 
ATOM   34   C CA  . LEU A 1 56  ? 89.002  93.331  92.994  1.00 93.39  ? 56  LEU A CA  1 
ATOM   35   C C   . LEU A 1 56  ? 90.426  93.066  93.496  1.00 102.53 ? 56  LEU A C   1 
ATOM   36   O O   . LEU A 1 56  ? 91.026  93.931  94.134  1.00 101.68 ? 56  LEU A O   1 
ATOM   37   C CB  . LEU A 1 56  ? 87.948  92.778  93.968  1.00 93.48  ? 56  LEU A CB  1 
ATOM   38   C CG  . LEU A 1 56  ? 87.319  93.754  94.959  1.00 91.93  ? 56  LEU A CG  1 
ATOM   39   C CD1 . LEU A 1 56  ? 88.359  94.538  95.733  1.00 90.85  ? 56  LEU A CD1 1 
ATOM   40   C CD2 . LEU A 1 56  ? 86.413  94.711  94.224  1.00 124.99 ? 56  LEU A CD2 1 
ATOM   41   N N   . LEU A 1 57  ? 90.961  91.863  93.229  1.00 100.07 ? 57  LEU A N   1 
ATOM   42   C CA  . LEU A 1 57  ? 92.299  91.495  93.673  1.00 95.85  ? 57  LEU A CA  1 
ATOM   43   C C   . LEU A 1 57  ? 93.335  92.299  92.900  1.00 87.63  ? 57  LEU A C   1 
ATOM   44   O O   . LEU A 1 57  ? 94.221  92.896  93.498  1.00 92.69  ? 57  LEU A O   1 
ATOM   45   C CB  . LEU A 1 57  ? 92.518  89.992  93.480  1.00 100.93 ? 57  LEU A CB  1 
ATOM   46   C CG  . LEU A 1 57  ? 91.738  89.095  94.430  1.00 122.16 ? 57  LEU A CG  1 
ATOM   47   C CD1 . LEU A 1 57  ? 91.721  87.662  93.918  1.00 144.69 ? 57  LEU A CD1 1 
ATOM   48   C CD2 . LEU A 1 57  ? 92.341  89.173  95.825  1.00 132.82 ? 57  LEU A CD2 1 
ATOM   49   N N   . VAL A 1 58  ? 93.236  92.323  91.563  1.00 72.88  ? 58  VAL A N   1 
ATOM   50   C CA  . VAL A 1 58  ? 94.218  93.023  90.739  1.00 65.68  ? 58  VAL A CA  1 
ATOM   51   C C   . VAL A 1 58  ? 94.168  94.533  91.010  1.00 77.94  ? 58  VAL A C   1 
ATOM   52   O O   . VAL A 1 58  ? 95.220  95.146  91.084  1.00 73.64  ? 58  VAL A O   1 
ATOM   53   C CB  . VAL A 1 58  ? 94.002  92.694  89.254  1.00 63.74  ? 58  VAL A CB  1 
ATOM   54   C CG1 . VAL A 1 58  ? 94.963  93.442  88.346  1.00 70.83  ? 58  VAL A CG1 1 
ATOM   55   C CG2 . VAL A 1 58  ? 94.088  91.186  89.020  1.00 69.62  ? 58  VAL A CG2 1 
ATOM   56   N N   . ALA A 1 59  ? 92.973  95.122  91.236  1.00 84.08  ? 59  ALA A N   1 
ATOM   57   C CA  . ALA A 1 59  ? 92.841  96.523  91.613  1.00 74.09  ? 59  ALA A CA  1 
ATOM   58   C C   . ALA A 1 59  ? 93.491  96.816  92.968  1.00 73.41  ? 59  ALA A C   1 
ATOM   59   O O   . ALA A 1 59  ? 94.121  97.856  93.128  1.00 83.11  ? 59  ALA A O   1 
ATOM   60   C CB  . ALA A 1 59  ? 91.387  96.909  91.632  1.00 89.28  ? 59  ALA A CB  1 
ATOM   61   N N   . SER A 1 60  ? 93.349  95.901  93.935  1.00 78.06  ? 60  SER A N   1 
ATOM   62   C CA  . SER A 1 60  ? 93.920  96.073  95.263  1.00 91.79  ? 60  SER A CA  1 
ATOM   63   C C   . SER A 1 60  ? 95.442  95.919  95.247  1.00 98.68  ? 60  SER A C   1 
ATOM   64   O O   . SER A 1 60  ? 96.142  96.707  95.877  1.00 94.01  ? 60  SER A O   1 
ATOM   65   C CB  . SER A 1 60  ? 93.301  95.107  96.237  1.00 105.60 ? 60  SER A CB  1 
ATOM   66   O OG  . SER A 1 60  ? 91.895  95.291  96.318  1.00 123.72 ? 60  SER A OG  1 
ATOM   67   N N   . LEU A 1 61  ? 95.946  94.897  94.532  1.00 100.87 ? 61  LEU A N   1 
ATOM   68   C CA  . LEU A 1 61  ? 97.363  94.544  94.523  1.00 87.48  ? 61  LEU A CA  1 
ATOM   69   C C   . LEU A 1 61  ? 98.160  95.520  93.663  1.00 85.77  ? 61  LEU A C   1 
ATOM   70   O O   . LEU A 1 61  ? 99.171  96.026  94.128  1.00 107.92 ? 61  LEU A O   1 
ATOM   71   C CB  . LEU A 1 61  ? 97.539  93.105  94.023  1.00 80.72  ? 61  LEU A CB  1 
ATOM   72   C CG  . LEU A 1 61  ? 97.006  92.005  94.938  1.00 79.39  ? 61  LEU A CG  1 
ATOM   73   C CD1 . LEU A 1 61  ? 97.096  90.646  94.267  1.00 86.40  ? 61  LEU A CD1 1 
ATOM   74   C CD2 . LEU A 1 61  ? 97.742  91.976  96.256  1.00 88.82  ? 61  LEU A CD2 1 
ATOM   75   N N   . ALA A 1 62  ? 97.729  95.790  92.422  1.00 92.68  ? 62  ALA A N   1 
ATOM   76   C CA  . ALA A 1 62  ? 98.423  96.721  91.532  1.00 86.65  ? 62  ALA A CA  1 
ATOM   77   C C   . ALA A 1 62  ? 98.192  98.177  91.943  1.00 75.92  ? 62  ALA A C   1 
ATOM   78   O O   . ALA A 1 62  ? 99.035  99.034  91.688  1.00 87.06  ? 62  ALA A O   1 
ATOM   79   C CB  . ALA A 1 62  ? 97.987  96.500  90.107  1.00 91.07  ? 62  ALA A CB  1 
ATOM   80   N N   . GLY A 1 63  ? 97.048  98.459  92.567  1.00 80.31  ? 63  GLY A N   1 
ATOM   81   C CA  . GLY A 1 63  ? 96.808  99.749  93.194  1.00 83.34  ? 63  GLY A CA  1 
ATOM   82   C C   . GLY A 1 63  ? 97.806  100.037 94.314  1.00 71.01  ? 63  GLY A C   1 
ATOM   83   O O   . GLY A 1 63  ? 98.421  101.086 94.323  1.00 78.34  ? 63  GLY A O   1 
ATOM   84   N N   . ALA A 1 64  ? 97.975  99.098  95.244  1.00 75.12  ? 64  ALA A N   1 
ATOM   85   C CA  . ALA A 1 64  ? 98.857  99.269  96.386  1.00 83.02  ? 64  ALA A CA  1 
ATOM   86   C C   . ALA A 1 64  ? 100.331 99.194  95.983  1.00 91.41  ? 64  ALA A C   1 
ATOM   87   O O   . ALA A 1 64  ? 101.108 100.037 96.409  1.00 114.86 ? 64  ALA A O   1 
ATOM   88   C CB  . ALA A 1 64  ? 98.524  98.250  97.456  1.00 89.99  ? 64  ALA A CB  1 
ATOM   89   N N   . PHE A 1 65  ? 100.735 98.214  95.164  1.00 87.89  ? 65  PHE A N   1 
ATOM   90   C CA  . PHE A 1 65  ? 102.139 97.992  94.825  1.00 89.81  ? 65  PHE A CA  1 
ATOM   91   C C   . PHE A 1 65  ? 102.790 99.227  94.192  1.00 86.53  ? 65  PHE A C   1 
ATOM   92   O O   . PHE A 1 65  ? 103.928 99.568  94.511  1.00 106.26 ? 65  PHE A O   1 
ATOM   93   C CB  . PHE A 1 65  ? 102.266 96.777  93.901  1.00 88.60  ? 65  PHE A CB  1 
ATOM   94   C CG  . PHE A 1 65  ? 103.677 96.360  93.574  1.00 101.92 ? 65  PHE A CG  1 
ATOM   95   C CD1 . PHE A 1 65  ? 104.619 96.095  94.566  1.00 110.23 ? 65  PHE A CD1 1 
ATOM   96   C CD2 . PHE A 1 65  ? 104.051 96.188  92.257  1.00 113.35 ? 65  PHE A CD2 1 
ATOM   97   C CE1 . PHE A 1 65  ? 105.915 95.732  94.234  1.00 101.57 ? 65  PHE A CE1 1 
ATOM   98   C CE2 . PHE A 1 65  ? 105.341 95.792  91.926  1.00 118.35 ? 65  PHE A CE2 1 
ATOM   99   C CZ  . PHE A 1 65  ? 106.271 95.566  92.918  1.00 111.04 ? 65  PHE A CZ  1 
ATOM   100  N N   . GLY A 1 66  ? 102.080 99.924  93.311  1.00 86.51  ? 66  GLY A N   1 
ATOM   101  C CA  . GLY A 1 66  ? 102.643 101.095 92.663  1.00 81.53  ? 66  GLY A CA  1 
ATOM   102  C C   . GLY A 1 66  ? 102.471 102.397 93.448  1.00 79.57  ? 66  GLY A C   1 
ATOM   103  O O   . GLY A 1 66  ? 102.867 103.451 92.945  1.00 98.39  ? 66  GLY A O   1 
ATOM   104  N N   . SER A 1 67  ? 101.906 102.348 94.666  1.00 77.18  ? 67  SER A N   1 
ATOM   105  C CA  . SER A 1 67  ? 101.423 103.558 95.329  1.00 87.51  ? 67  SER A CA  1 
ATOM   106  C C   . SER A 1 67  ? 101.857 103.643 96.791  1.00 72.32  ? 67  SER A C   1 
ATOM   107  O O   . SER A 1 67  ? 102.644 104.514 97.140  1.00 87.98  ? 67  SER A O   1 
ATOM   108  C CB  . SER A 1 67  ? 99.912  103.684 95.218  1.00 87.70  ? 67  SER A CB  1 
ATOM   109  O OG  . SER A 1 67  ? 99.484  103.507 93.878  1.00 91.55  ? 67  SER A OG  1 
ATOM   110  N N   . SER A 1 68  ? 101.300 102.768 97.631  1.00 69.60  ? 68  SER A N   1 
ATOM   111  C CA  . SER A 1 68  ? 101.566 102.783 99.063  1.00 70.78  ? 68  SER A CA  1 
ATOM   112  C C   . SER A 1 68  ? 102.871 102.047 99.372  1.00 69.38  ? 68  SER A C   1 
ATOM   113  O O   . SER A 1 68  ? 103.627 102.459 100.241 1.00 56.54  ? 68  SER A O   1 
ATOM   114  C CB  . SER A 1 68  ? 100.398 102.218 99.827  1.00 64.31  ? 68  SER A CB  1 
ATOM   115  O OG  . SER A 1 68  ? 100.113 100.891 99.435  1.00 57.57  ? 68  SER A OG  1 
ATOM   116  N N   . PHE A 1 69  ? 103.163 100.978 98.623  1.00 72.56  ? 69  PHE A N   1 
ATOM   117  C CA  . PHE A 1 69  ? 104.435 100.280 98.737  1.00 64.25  ? 69  PHE A CA  1 
ATOM   118  C C   . PHE A 1 69  ? 105.607 101.205 98.398  1.00 64.17  ? 69  PHE A C   1 
ATOM   119  O O   . PHE A 1 69  ? 106.625 101.151 99.080  1.00 67.55  ? 69  PHE A O   1 
ATOM   120  C CB  . PHE A 1 69  ? 104.391 99.019  97.875  1.00 62.62  ? 69  PHE A CB  1 
ATOM   121  C CG  . PHE A 1 69  ? 105.712 98.319  97.676  1.00 65.43  ? 69  PHE A CG  1 
ATOM   122  C CD1 . PHE A 1 69  ? 106.600 98.776  96.718  1.00 61.93  ? 69  PHE A CD1 1 
ATOM   123  C CD2 . PHE A 1 69  ? 106.052 97.207  98.438  1.00 65.24  ? 69  PHE A CD2 1 
ATOM   124  C CE1 . PHE A 1 69  ? 107.806 98.135  96.520  1.00 69.12  ? 69  PHE A CE1 1 
ATOM   125  C CE2 . PHE A 1 69  ? 107.263 96.576  98.242  1.00 68.80  ? 69  PHE A CE2 1 
ATOM   126  C CZ  . PHE A 1 69  ? 108.128 97.041  97.283  1.00 67.98  ? 69  PHE A CZ  1 
ATOM   127  N N   . LEU A 1 70  ? 105.466 102.080 97.385  1.00 64.51  ? 70  LEU A N   1 
ATOM   128  C CA  . LEU A 1 70  ? 106.517 103.030 97.051  1.00 64.30  ? 70  LEU A CA  1 
ATOM   129  C C   . LEU A 1 70  ? 106.673 104.116 98.119  1.00 61.35  ? 70  LEU A C   1 
ATOM   130  O O   . LEU A 1 70  ? 107.770 104.638 98.272  1.00 68.02  ? 70  LEU A O   1 
ATOM   131  C CB  . LEU A 1 70  ? 106.245 103.689 95.693  1.00 67.81  ? 70  LEU A CB  1 
ATOM   132  C CG  . LEU A 1 70  ? 106.693 102.922 94.466  1.00 79.93  ? 70  LEU A CG  1 
ATOM   133  C CD1 . LEU A 1 70  ? 106.590 103.808 93.247  1.00 89.46  ? 70  LEU A CD1 1 
ATOM   134  C CD2 . LEU A 1 70  ? 108.102 102.379 94.626  1.00 91.06  ? 70  LEU A CD2 1 
ATOM   135  N N   . TYR A 1 71  ? 105.605 104.509 98.817  1.00 52.91  ? 71  TYR A N   1 
ATOM   136  C CA  . TYR A 1 71  ? 105.764 105.417 99.933  1.00 56.45  ? 71  TYR A CA  1 
ATOM   137  C C   . TYR A 1 71  ? 106.636 104.734 100.990 1.00 55.08  ? 71  TYR A C   1 
ATOM   138  O O   . TYR A 1 71  ? 107.635 105.290 101.445 1.00 57.20  ? 71  TYR A O   1 
ATOM   139  C CB  . TYR A 1 71  ? 104.411 105.874 100.495 1.00 57.32  ? 71  TYR A CB  1 
ATOM   140  C CG  . TYR A 1 71  ? 104.546 106.666 101.784 1.00 58.27  ? 71  TYR A CG  1 
ATOM   141  C CD1 . TYR A 1 71  ? 104.962 107.991 101.779 1.00 55.99  ? 71  TYR A CD1 1 
ATOM   142  C CD2 . TYR A 1 71  ? 104.308 106.059 103.004 1.00 57.81  ? 71  TYR A CD2 1 
ATOM   143  C CE1 . TYR A 1 71  ? 105.108 108.694 102.964 1.00 63.91  ? 71  TYR A CE1 1 
ATOM   144  C CE2 . TYR A 1 71  ? 104.459 106.750 104.191 1.00 70.40  ? 71  TYR A CE2 1 
ATOM   145  C CZ  . TYR A 1 71  ? 104.870 108.072 104.173 1.00 68.08  ? 71  TYR A CZ  1 
ATOM   146  O OH  . TYR A 1 71  ? 105.014 108.768 105.340 1.00 73.98  ? 71  TYR A OH  1 
ATOM   147  N N   . GLY A 1 72  ? 106.254 103.516 101.376 1.00 51.27  ? 72  GLY A N   1 
ATOM   148  C CA  . GLY A 1 72  ? 106.978 102.755 102.375 1.00 47.45  ? 72  GLY A CA  1 
ATOM   149  C C   . GLY A 1 72  ? 108.427 102.466 101.996 1.00 46.18  ? 72  GLY A C   1 
ATOM   150  O O   . GLY A 1 72  ? 109.311 102.586 102.827 1.00 47.62  ? 72  GLY A O   1 
ATOM   151  N N   . TYR A 1 73  ? 108.688 102.091 100.744 1.00 51.55  ? 73  TYR A N   1 
ATOM   152  C CA  . TYR A 1 73  ? 110.048 101.883 100.254 1.00 48.36  ? 73  TYR A CA  1 
ATOM   153  C C   . TYR A 1 73  ? 110.894 103.154 100.399 1.00 43.78  ? 73  TYR A C   1 
ATOM   154  O O   . TYR A 1 73  ? 112.022 103.105 100.850 1.00 52.75  ? 73  TYR A O   1 
ATOM   155  C CB  . TYR A 1 73  ? 109.976 101.421 98.799  1.00 41.20  ? 73  TYR A CB  1 
ATOM   156  C CG  . TYR A 1 73  ? 111.323 101.067 98.197  1.00 44.72  ? 73  TYR A CG  1 
ATOM   157  C CD1 . TYR A 1 73  ? 111.868 99.810  98.355  1.00 54.05  ? 73  TYR A CD1 1 
ATOM   158  C CD2 . TYR A 1 73  ? 112.048 101.995 97.461  1.00 52.13  ? 73  TYR A CD2 1 
ATOM   159  C CE1 . TYR A 1 73  ? 113.103 99.495  97.811  1.00 56.49  ? 73  TYR A CE1 1 
ATOM   160  C CE2 . TYR A 1 73  ? 113.274 101.691 96.906  1.00 48.94  ? 73  TYR A CE2 1 
ATOM   161  C CZ  . TYR A 1 73  ? 113.812 100.433 97.094  1.00 50.86  ? 73  TYR A CZ  1 
ATOM   162  O OH  . TYR A 1 73  ? 115.022 100.089 96.560  1.00 52.28  ? 73  TYR A OH  1 
ATOM   163  N N   . ASN A 1 74  ? 110.324 104.310 100.076 1.00 48.50  ? 74  ASN A N   1 
ATOM   164  C CA  . ASN A 1 74  ? 111.048 105.563 100.090 1.00 48.06  ? 74  ASN A CA  1 
ATOM   165  C C   . ASN A 1 74  ? 111.340 106.083 101.502 1.00 51.89  ? 74  ASN A C   1 
ATOM   166  O O   . ASN A 1 74  ? 112.107 107.027 101.640 1.00 66.67  ? 74  ASN A O   1 
ATOM   167  C CB  . ASN A 1 74  ? 110.313 106.585 99.214  1.00 47.92  ? 74  ASN A CB  1 
ATOM   168  C CG  . ASN A 1 74  ? 110.694 106.404 97.757  1.00 54.69  ? 74  ASN A CG  1 
ATOM   169  O OD1 . ASN A 1 74  ? 111.837 106.648 97.372  1.00 67.58  ? 74  ASN A OD1 1 
ATOM   170  N ND2 . ASN A 1 74  ? 109.770 105.941 96.938  1.00 58.09  ? 74  ASN A ND2 1 
ATOM   171  N N   . LEU A 1 75  ? 110.772 105.494 102.557 1.00 56.05  ? 75  LEU A N   1 
ATOM   172  C CA  . LEU A 1 75  ? 111.176 105.810 103.923 1.00 60.48  ? 75  LEU A CA  1 
ATOM   173  C C   . LEU A 1 75  ? 112.509 105.145 104.256 1.00 61.40  ? 75  LEU A C   1 
ATOM   174  O O   . LEU A 1 75  ? 113.353 105.754 104.905 1.00 74.16  ? 75  LEU A O   1 
ATOM   175  C CB  . LEU A 1 75  ? 110.108 105.332 104.917 1.00 67.68  ? 75  LEU A CB  1 
ATOM   176  C CG  . LEU A 1 75  ? 108.752 106.030 104.826 1.00 71.28  ? 75  LEU A CG  1 
ATOM   177  C CD1 . LEU A 1 75  ? 107.785 105.405 105.826 1.00 66.57  ? 75  LEU A CD1 1 
ATOM   178  C CD2 . LEU A 1 75  ? 108.889 107.547 105.024 1.00 67.77  ? 75  LEU A CD2 1 
ATOM   179  N N   . SER A 1 76  ? 112.690 103.885 103.843 1.00 61.22  ? 76  SER A N   1 
ATOM   180  C CA  . SER A 1 76  ? 113.797 103.068 104.310 1.00 55.08  ? 76  SER A CA  1 
ATOM   181  C C   . SER A 1 76  ? 114.925 102.913 103.283 1.00 49.48  ? 76  SER A C   1 
ATOM   182  O O   . SER A 1 76  ? 116.016 102.484 103.668 1.00 61.03  ? 76  SER A O   1 
ATOM   183  C CB  . SER A 1 76  ? 113.281 101.729 104.764 1.00 58.53  ? 76  SER A CB  1 
ATOM   184  O OG  . SER A 1 76  ? 112.852 100.935 103.677 1.00 51.36  ? 76  SER A OG  1 
ATOM   185  N N   . VAL A 1 77  ? 114.689 103.239 102.006 1.00 51.44  ? 77  VAL A N   1 
ATOM   186  C CA  . VAL A 1 77  ? 115.714 103.106 100.973 1.00 61.77  ? 77  VAL A CA  1 
ATOM   187  C C   . VAL A 1 77  ? 116.906 104.010 101.283 1.00 64.14  ? 77  VAL A C   1 
ATOM   188  O O   . VAL A 1 77  ? 118.027 103.728 100.872 1.00 73.87  ? 77  VAL A O   1 
ATOM   189  C CB  . VAL A 1 77  ? 115.183 103.434 99.564  1.00 68.33  ? 77  VAL A CB  1 
ATOM   190  C CG1 . VAL A 1 77  ? 114.762 104.898 99.402  1.00 71.84  ? 77  VAL A CG1 1 
ATOM   191  C CG2 . VAL A 1 77  ? 116.183 103.041 98.487  1.00 64.59  ? 77  VAL A CG2 1 
ATOM   192  N N   . VAL A 1 78  ? 116.646 105.114 101.988 1.00 65.98  ? 78  VAL A N   1 
ATOM   193  C CA  . VAL A 1 78  ? 117.612 106.193 102.158 1.00 62.63  ? 78  VAL A CA  1 
ATOM   194  C C   . VAL A 1 78  ? 118.629 105.842 103.250 1.00 56.33  ? 78  VAL A C   1 
ATOM   195  O O   . VAL A 1 78  ? 119.704 106.430 103.287 1.00 56.42  ? 78  VAL A O   1 
ATOM   196  C CB  . VAL A 1 78  ? 116.834 107.498 102.434 1.00 63.14  ? 78  VAL A CB  1 
ATOM   197  C CG1 . VAL A 1 78  ? 116.430 107.632 103.904 1.00 57.42  ? 78  VAL A CG1 1 
ATOM   198  C CG2 . VAL A 1 78  ? 117.592 108.713 101.955 1.00 77.73  ? 78  VAL A CG2 1 
ATOM   199  N N   . ASN A 1 79  ? 118.321 104.843 104.096 1.00 55.29  ? 79  ASN A N   1 
ATOM   200  C CA  . ASN A 1 79  ? 119.141 104.444 105.235 1.00 51.51  ? 79  ASN A CA  1 
ATOM   201  C C   . ASN A 1 79  ? 120.466 103.773 104.820 1.00 53.21  ? 79  ASN A C   1 
ATOM   202  O O   . ASN A 1 79  ? 121.539 104.285 105.114 1.00 59.28  ? 79  ASN A O   1 
ATOM   203  C CB  . ASN A 1 79  ? 118.325 103.564 106.168 1.00 51.78  ? 79  ASN A CB  1 
ATOM   204  C CG  . ASN A 1 79  ? 119.165 102.829 107.188 1.00 56.97  ? 79  ASN A CG  1 
ATOM   205  O OD1 . ASN A 1 79  ? 119.898 103.463 107.936 1.00 63.71  ? 79  ASN A OD1 1 
ATOM   206  N ND2 . ASN A 1 79  ? 119.043 101.505 107.242 1.00 60.57  ? 79  ASN A ND2 1 
ATOM   207  N N   . ALA A 1 80  ? 120.407 102.640 104.124 1.00 64.31  ? 80  ALA A N   1 
ATOM   208  C CA  . ALA A 1 80  ? 121.581 101.803 103.866 1.00 66.14  ? 80  ALA A CA  1 
ATOM   209  C C   . ALA A 1 80  ? 122.646 102.478 102.989 1.00 74.39  ? 80  ALA A C   1 
ATOM   210  O O   . ALA A 1 80  ? 123.830 102.282 103.261 1.00 88.25  ? 80  ALA A O   1 
ATOM   211  C CB  . ALA A 1 80  ? 121.135 100.500 103.225 1.00 91.47  ? 80  ALA A CB  1 
ATOM   212  N N   . PRO A 1 81  ? 122.338 103.258 101.910 1.00 66.04  ? 81  PRO A N   1 
ATOM   213  C CA  . PRO A 1 81  ? 123.373 103.945 101.145 1.00 61.96  ? 81  PRO A CA  1 
ATOM   214  C C   . PRO A 1 81  ? 123.954 105.218 101.768 1.00 55.86  ? 81  PRO A C   1 
ATOM   215  O O   . PRO A 1 81  ? 124.794 105.853 101.152 1.00 59.46  ? 81  PRO A O   1 
ATOM   216  C CB  . PRO A 1 81  ? 122.654 104.281 99.823  1.00 62.04  ? 81  PRO A CB  1 
ATOM   217  C CG  . PRO A 1 81  ? 121.241 104.520 100.233 1.00 60.54  ? 81  PRO A CG  1 
ATOM   218  C CD  . PRO A 1 81  ? 121.015 103.492 101.324 1.00 61.74  ? 81  PRO A CD  1 
ATOM   219  N N   . THR A 1 82  ? 123.581 105.571 103.009 1.00 59.54  ? 82  THR A N   1 
ATOM   220  C CA  . THR A 1 82  ? 124.000 106.824 103.644 1.00 53.89  ? 82  THR A CA  1 
ATOM   221  C C   . THR A 1 82  ? 125.509 107.094 103.535 1.00 57.35  ? 82  THR A C   1 
ATOM   222  O O   . THR A 1 82  ? 125.879 108.200 103.165 1.00 65.96  ? 82  THR A O   1 
ATOM   223  C CB  . THR A 1 82  ? 123.601 106.860 105.121 1.00 53.32  ? 82  THR A CB  1 
ATOM   224  O OG1 . THR A 1 82  ? 122.182 106.893 105.205 1.00 47.41  ? 82  THR A OG1 1 
ATOM   225  C CG2 . THR A 1 82  ? 124.147 108.050 105.874 1.00 58.40  ? 82  THR A CG2 1 
ATOM   226  N N   . PRO A 1 83  ? 126.447 106.176 103.882 1.00 58.48  ? 83  PRO A N   1 
ATOM   227  C CA  . PRO A 1 83  ? 127.873 106.471 103.788 1.00 60.95  ? 83  PRO A CA  1 
ATOM   228  C C   . PRO A 1 83  ? 128.418 106.675 102.370 1.00 57.85  ? 83  PRO A C   1 
ATOM   229  O O   . PRO A 1 83  ? 129.417 107.357 102.194 1.00 66.28  ? 83  PRO A O   1 
ATOM   230  C CB  . PRO A 1 83  ? 128.531 105.238 104.439 1.00 70.77  ? 83  PRO A CB  1 
ATOM   231  C CG  . PRO A 1 83  ? 127.549 104.130 104.232 1.00 71.56  ? 83  PRO A CG  1 
ATOM   232  C CD  . PRO A 1 83  ? 126.208 104.820 104.379 1.00 71.51  ? 83  PRO A CD  1 
ATOM   233  N N   . TYR A 1 84  ? 127.756 106.081 101.365 1.00 61.63  ? 84  TYR A N   1 
ATOM   234  C CA  . TYR A 1 84  ? 128.121 106.198 99.965  1.00 59.42  ? 84  TYR A CA  1 
ATOM   235  C C   . TYR A 1 84  ? 127.611 107.519 99.396  1.00 61.11  ? 84  TYR A C   1 
ATOM   236  O O   . TYR A 1 84  ? 128.318 108.154 98.615  1.00 70.40  ? 84  TYR A O   1 
ATOM   237  C CB  . TYR A 1 84  ? 127.599 104.988 99.182  1.00 62.60  ? 84  TYR A CB  1 
ATOM   238  C CG  . TYR A 1 84  ? 127.980 103.665 99.837  1.00 69.95  ? 84  TYR A CG  1 
ATOM   239  C CD1 . TYR A 1 84  ? 129.296 103.394 100.166 1.00 80.57  ? 84  TYR A CD1 1 
ATOM   240  C CD2 . TYR A 1 84  ? 127.029 102.724 100.198 1.00 79.40  ? 84  TYR A CD2 1 
ATOM   241  C CE1 . TYR A 1 84  ? 129.652 102.246 100.849 1.00 91.21  ? 84  TYR A CE1 1 
ATOM   242  C CE2 . TYR A 1 84  ? 127.368 101.556 100.864 1.00 91.73  ? 84  TYR A CE2 1 
ATOM   243  C CZ  . TYR A 1 84  ? 128.693 101.311 101.185 1.00 101.42 ? 84  TYR A CZ  1 
ATOM   244  O OH  . TYR A 1 84  ? 129.095 100.168 101.829 1.00 114.31 ? 84  TYR A OH  1 
ATOM   245  N N   . ILE A 1 85  ? 126.407 107.950 99.797  1.00 58.83  ? 85  ILE A N   1 
ATOM   246  C CA  . ILE A 1 85  ? 125.863 109.222 99.344  1.00 60.00  ? 85  ILE A CA  1 
ATOM   247  C C   . ILE A 1 85  ? 126.627 110.388 99.984  1.00 58.12  ? 85  ILE A C   1 
ATOM   248  O O   . ILE A 1 85  ? 126.921 111.360 99.304  1.00 65.37  ? 85  ILE A O   1 
ATOM   249  C CB  . ILE A 1 85  ? 124.343 109.325 99.573  1.00 60.07  ? 85  ILE A CB  1 
ATOM   250  C CG1 . ILE A 1 85  ? 123.596 108.200 98.852  1.00 63.18  ? 85  ILE A CG1 1 
ATOM   251  C CG2 . ILE A 1 85  ? 123.843 110.703 99.138  1.00 62.29  ? 85  ILE A CG2 1 
ATOM   252  C CD1 . ILE A 1 85  ? 122.162 107.978 99.308  1.00 67.68  ? 85  ILE A CD1 1 
ATOM   253  N N   . LYS A 1 86  ? 126.979 110.321 101.267 1.00 58.06  ? 86  LYS A N   1 
ATOM   254  C CA  . LYS A 1 86  ? 127.746 111.392 101.894 1.00 56.91  ? 86  LYS A CA  1 
ATOM   255  C C   . LYS A 1 86  ? 129.137 111.510 101.273 1.00 57.22  ? 86  LYS A C   1 
ATOM   256  O O   . LYS A 1 86  ? 129.630 112.624 101.105 1.00 60.16  ? 86  LYS A O   1 
ATOM   257  C CB  . LYS A 1 86  ? 127.868 111.177 103.406 1.00 56.39  ? 86  LYS A CB  1 
ATOM   258  C CG  . LYS A 1 86  ? 126.607 111.501 104.193 1.00 58.74  ? 86  LYS A CG  1 
ATOM   259  C CD  . LYS A 1 86  ? 126.812 111.338 105.670 1.00 69.07  ? 86  LYS A CD  1 
ATOM   260  C CE  . LYS A 1 86  ? 125.660 111.811 106.516 1.00 83.95  ? 86  LYS A CE  1 
ATOM   261  N NZ  . LYS A 1 86  ? 125.872 111.429 107.933 1.00 101.20 ? 86  LYS A NZ  1 
ATOM   262  N N   . ALA A 1 87  ? 129.777 110.383 100.928 1.00 54.95  ? 87  ALA A N   1 
ATOM   263  C CA  . ALA A 1 87  ? 131.070 110.413 100.261 1.00 59.32  ? 87  ALA A CA  1 
ATOM   264  C C   . ALA A 1 87  ? 130.975 111.081 98.889  1.00 61.16  ? 87  ALA A C   1 
ATOM   265  O O   . ALA A 1 87  ? 131.883 111.803 98.487  1.00 65.64  ? 87  ALA A O   1 
ATOM   266  C CB  . ALA A 1 87  ? 131.608 109.013 100.142 1.00 85.33  ? 87  ALA A CB  1 
ATOM   267  N N   . PHE A 1 88  ? 129.846 110.879 98.195  1.00 64.74  ? 88  PHE A N   1 
ATOM   268  C CA  . PHE A 1 88  ? 129.540 111.516 96.916  1.00 55.96  ? 88  PHE A CA  1 
ATOM   269  C C   . PHE A 1 88  ? 129.331 113.020 97.073  1.00 61.93  ? 88  PHE A C   1 
ATOM   270  O O   . PHE A 1 88  ? 129.832 113.780 96.248  1.00 70.53  ? 88  PHE A O   1 
ATOM   271  C CB  . PHE A 1 88  ? 128.336 110.807 96.291  1.00 56.22  ? 88  PHE A CB  1 
ATOM   272  C CG  . PHE A 1 88  ? 127.593 111.554 95.223  1.00 56.69  ? 88  PHE A CG  1 
ATOM   273  C CD1 . PHE A 1 88  ? 128.249 111.998 94.084  1.00 57.31  ? 88  PHE A CD1 1 
ATOM   274  C CD2 . PHE A 1 88  ? 126.219 111.757 95.350  1.00 59.20  ? 88  PHE A CD2 1 
ATOM   275  C CE1 . PHE A 1 88  ? 127.548 112.690 93.106  1.00 67.51  ? 88  PHE A CE1 1 
ATOM   276  C CE2 . PHE A 1 88  ? 125.516 112.436 94.365  1.00 59.74  ? 88  PHE A CE2 1 
ATOM   277  C CZ  . PHE A 1 88  ? 126.192 112.902 93.250  1.00 64.42  ? 88  PHE A CZ  1 
ATOM   278  N N   . TYR A 1 89  ? 128.612 113.473 98.119  1.00 62.11  ? 89  TYR A N   1 
ATOM   279  C CA  . TYR A 1 89  ? 128.391 114.892 98.352  1.00 49.72  ? 89  TYR A CA  1 
ATOM   280  C C   . TYR A 1 89  ? 129.717 115.595 98.646  1.00 54.84  ? 89  TYR A C   1 
ATOM   281  O O   . TYR A 1 89  ? 129.979 116.672 98.118  1.00 66.71  ? 89  TYR A O   1 
ATOM   282  C CB  . TYR A 1 89  ? 127.431 115.115 99.510  1.00 46.96  ? 89  TYR A CB  1 
ATOM   283  C CG  . TYR A 1 89  ? 125.967 114.828 99.249  1.00 51.50  ? 89  TYR A CG  1 
ATOM   284  C CD1 . TYR A 1 89  ? 125.542 114.282 98.058  1.00 54.42  ? 89  TYR A CD1 1 
ATOM   285  C CD2 . TYR A 1 89  ? 125.004 115.112 100.217 1.00 60.86  ? 89  TYR A CD2 1 
ATOM   286  C CE1 . TYR A 1 89  ? 124.193 114.029 97.827  1.00 67.09  ? 89  TYR A CE1 1 
ATOM   287  C CE2 . TYR A 1 89  ? 123.658 114.858 99.998  1.00 74.14  ? 89  TYR A CE2 1 
ATOM   288  C CZ  . TYR A 1 89  ? 123.249 114.316 98.792  1.00 62.52  ? 89  TYR A CZ  1 
ATOM   289  O OH  . TYR A 1 89  ? 121.934 114.057 98.536  1.00 67.89  ? 89  TYR A OH  1 
ATOM   290  N N   . ASN A 1 90  ? 130.535 114.999 99.514  1.00 56.97  ? 90  ASN A N   1 
ATOM   291  C CA  . ASN A 1 90  ? 131.846 115.500 99.879  1.00 65.94  ? 90  ASN A CA  1 
ATOM   292  C C   . ASN A 1 90  ? 132.695 115.673 98.620  1.00 64.75  ? 90  ASN A C   1 
ATOM   293  O O   . ASN A 1 90  ? 133.142 116.781 98.319  1.00 82.70  ? 90  ASN A O   1 
ATOM   294  C CB  . ASN A 1 90  ? 132.435 114.586 100.960 1.00 66.48  ? 90  ASN A CB  1 
ATOM   295  C CG  . ASN A 1 90  ? 133.825 114.952 101.451 1.00 73.69  ? 90  ASN A CG  1 
ATOM   296  O OD1 . ASN A 1 90  ? 134.499 115.833 100.915 1.00 65.14  ? 90  ASN A OD1 1 
ATOM   297  N ND2 . ASN A 1 90  ? 134.263 114.249 102.482 1.00 88.16  ? 90  ASN A ND2 1 
ATOM   298  N N   . GLU A 1 91  ? 132.879 114.602 97.849  1.00 73.86  ? 91  GLU A N   1 
ATOM   299  C CA  . GLU A 1 91  ? 133.760 114.629 96.687  1.00 99.44  ? 91  GLU A CA  1 
ATOM   300  C C   . GLU A 1 91  ? 133.211 115.502 95.551  1.00 91.23  ? 91  GLU A C   1 
ATOM   301  O O   . GLU A 1 91  ? 133.979 115.893 94.678  1.00 110.43 ? 91  GLU A O   1 
ATOM   302  C CB  . GLU A 1 91  ? 134.028 113.195 96.223  1.00 146.25 ? 91  GLU A CB  1 
ATOM   303  C CG  . GLU A 1 91  ? 134.831 112.388 97.231  1.00 195.93 ? 91  GLU A CG  1 
ATOM   304  C CD  . GLU A 1 91  ? 134.981 110.908 96.920  1.00 238.43 ? 91  GLU A CD  1 
ATOM   305  O OE1 . GLU A 1 91  ? 134.600 110.490 95.804  1.00 264.97 ? 91  GLU A OE1 1 
ATOM   306  O OE2 . GLU A 1 91  ? 135.470 110.174 97.804  1.00 252.03 ? 91  GLU A OE2 1 
ATOM   307  N N   . SER A 1 92  ? 131.898 115.792 95.539  1.00 90.98  ? 92  SER A N   1 
ATOM   308  C CA  . SER A 1 92  ? 131.289 116.748 94.620  1.00 89.78  ? 92  SER A CA  1 
ATOM   309  C C   . SER A 1 92  ? 131.569 118.189 95.043  1.00 83.52  ? 92  SER A C   1 
ATOM   310  O O   . SER A 1 92  ? 131.829 119.047 94.201  1.00 94.62  ? 92  SER A O   1 
ATOM   311  C CB  . SER A 1 92  ? 129.800 116.546 94.512  1.00 89.49  ? 92  SER A CB  1 
ATOM   312  O OG  . SER A 1 92  ? 129.495 115.239 94.044  1.00 99.79  ? 92  SER A OG  1 
ATOM   313  N N   . TRP A 1 93  ? 131.478 118.454 96.349  1.00 85.57  ? 93  TRP A N   1 
ATOM   314  C CA  . TRP A 1 93  ? 131.600 119.795 96.891  1.00 81.87  ? 93  TRP A CA  1 
ATOM   315  C C   . TRP A 1 93  ? 133.026 120.314 96.741  1.00 79.54  ? 93  TRP A C   1 
ATOM   316  O O   . TRP A 1 93  ? 133.219 121.418 96.247  1.00 92.68  ? 93  TRP A O   1 
ATOM   317  C CB  . TRP A 1 93  ? 131.138 119.789 98.351  1.00 93.55  ? 93  TRP A CB  1 
ATOM   318  C CG  . TRP A 1 93  ? 131.103 121.133 99.030  1.00 106.28 ? 93  TRP A CG  1 
ATOM   319  C CD1 . TRP A 1 93  ? 132.163 121.840 99.527  1.00 103.74 ? 93  TRP A CD1 1 
ATOM   320  C CD2 . TRP A 1 93  ? 129.922 121.912 99.330  1.00 99.77  ? 93  TRP A CD2 1 
ATOM   321  N NE1 . TRP A 1 93  ? 131.730 123.006 100.098 1.00 91.38  ? 93  TRP A NE1 1 
ATOM   322  C CE2 . TRP A 1 93  ? 130.366 123.076 100.001 1.00 95.52  ? 93  TRP A CE2 1 
ATOM   323  C CE3 . TRP A 1 93  ? 128.550 121.735 99.102  1.00 97.06  ? 93  TRP A CE3 1 
ATOM   324  C CZ2 . TRP A 1 93  ? 129.481 124.056 100.438 1.00 110.32 ? 93  TRP A CZ2 1 
ATOM   325  C CZ3 . TRP A 1 93  ? 127.678 122.704 99.543  1.00 115.40 ? 93  TRP A CZ3 1 
ATOM   326  C CH2 . TRP A 1 93  ? 128.138 123.845 100.205 1.00 132.10 ? 93  TRP A CH2 1 
ATOM   327  N N   . GLU A 1 94  ? 134.038 119.528 97.129  1.00 91.82  ? 94  GLU A N   1 
ATOM   328  C CA  . GLU A 1 94  ? 135.418 119.991 97.053  1.00 108.02 ? 94  GLU A CA  1 
ATOM   329  C C   . GLU A 1 94  ? 135.819 120.197 95.591  1.00 124.07 ? 94  GLU A C   1 
ATOM   330  O O   . GLU A 1 94  ? 136.520 121.160 95.283  1.00 147.17 ? 94  GLU A O   1 
ATOM   331  C CB  . GLU A 1 94  ? 136.374 119.017 97.747  1.00 127.73 ? 94  GLU A CB  1 
ATOM   332  C CG  . GLU A 1 94  ? 137.816 119.504 97.781  1.00 154.89 ? 94  GLU A CG  1 
ATOM   333  C CD  . GLU A 1 94  ? 138.809 118.573 98.460  1.00 209.39 ? 94  GLU A CD  1 
ATOM   334  O OE1 . GLU A 1 94  ? 138.383 117.508 98.964  1.00 235.98 ? 94  GLU A OE1 1 
ATOM   335  O OE2 . GLU A 1 94  ? 140.013 118.911 98.479  1.00 220.13 ? 94  GLU A OE2 1 
ATOM   336  N N   . ARG A 1 95  ? 135.356 119.323 94.684  1.00 124.71 ? 95  ARG A N   1 
ATOM   337  C CA  . ARG A 1 95  ? 135.699 119.401 93.269  1.00 137.36 ? 95  ARG A CA  1 
ATOM   338  C C   . ARG A 1 95  ? 135.064 120.622 92.594  1.00 121.73 ? 95  ARG A C   1 
ATOM   339  O O   . ARG A 1 95  ? 135.616 121.126 91.616  1.00 143.52 ? 95  ARG A O   1 
ATOM   340  C CB  . ARG A 1 95  ? 135.314 118.078 92.593  1.00 166.80 ? 95  ARG A CB  1 
ATOM   341  C CG  . ARG A 1 95  ? 135.600 117.990 91.099  1.00 178.00 ? 95  ARG A CG  1 
ATOM   342  C CD  . ARG A 1 95  ? 134.372 118.266 90.254  1.00 176.00 ? 95  ARG A CD  1 
ATOM   343  N NE  . ARG A 1 95  ? 133.332 117.276 90.502  1.00 183.49 ? 95  ARG A NE  1 
ATOM   344  C CZ  . ARG A 1 95  ? 132.080 117.359 90.061  1.00 205.16 ? 95  ARG A CZ  1 
ATOM   345  N NH1 . ARG A 1 95  ? 131.206 116.428 90.398  1.00 211.95 ? 95  ARG A NH1 1 
ATOM   346  N NH2 . ARG A 1 95  ? 131.699 118.382 89.312  1.00 207.96 ? 95  ARG A NH2 1 
ATOM   347  N N   . ARG A 1 96  ? 133.927 121.111 93.112  1.00 110.58 ? 96  ARG A N   1 
ATOM   348  C CA  . ARG A 1 96  ? 133.240 122.273 92.555  1.00 107.82 ? 96  ARG A CA  1 
ATOM   349  C C   . ARG A 1 96  ? 133.738 123.584 93.170  1.00 122.95 ? 96  ARG A C   1 
ATOM   350  O O   . ARG A 1 96  ? 133.947 124.550 92.439  1.00 141.16 ? 96  ARG A O   1 
ATOM   351  C CB  . ARG A 1 96  ? 131.725 122.144 92.740  1.00 100.06 ? 96  ARG A CB  1 
ATOM   352  C CG  . ARG A 1 96  ? 131.087 121.163 91.771  1.00 122.63 ? 96  ARG A CG  1 
ATOM   353  C CD  . ARG A 1 96  ? 129.656 120.800 92.113  1.00 133.78 ? 96  ARG A CD  1 
ATOM   354  N NE  . ARG A 1 96  ? 128.742 121.928 92.234  1.00 121.85 ? 96  ARG A NE  1 
ATOM   355  C CZ  . ARG A 1 96  ? 127.426 121.807 92.365  1.00 128.08 ? 96  ARG A CZ  1 
ATOM   356  N NH1 . ARG A 1 96  ? 126.676 122.883 92.507  1.00 157.23 ? 96  ARG A NH1 1 
ATOM   357  N NH2 . ARG A 1 96  ? 126.858 120.612 92.352  1.00 135.10 ? 96  ARG A NH2 1 
ATOM   358  N N   . HIS A 1 97  ? 133.902 123.629 94.506  1.00 125.38 ? 97  HIS A N   1 
ATOM   359  C CA  . HIS A 1 97  ? 134.175 124.865 95.235  1.00 106.63 ? 97  HIS A CA  1 
ATOM   360  C C   . HIS A 1 97  ? 135.662 125.060 95.544  1.00 109.13 ? 97  HIS A C   1 
ATOM   361  O O   . HIS A 1 97  ? 136.067 126.159 95.913  1.00 134.27 ? 97  HIS A O   1 
ATOM   362  C CB  . HIS A 1 97  ? 133.357 124.928 96.529  1.00 99.99  ? 97  HIS A CB  1 
ATOM   363  C CG  . HIS A 1 97  ? 131.878 124.956 96.330  1.00 117.12 ? 97  HIS A CG  1 
ATOM   364  N ND1 . HIS A 1 97  ? 130.966 124.920 97.364  1.00 130.31 ? 97  HIS A ND1 1 
ATOM   365  C CD2 . HIS A 1 97  ? 131.157 125.013 95.208  1.00 145.29 ? 97  HIS A CD2 1 
ATOM   366  C CE1 . HIS A 1 97  ? 129.735 124.950 96.872  1.00 142.13 ? 97  HIS A CE1 1 
ATOM   367  N NE2 . HIS A 1 97  ? 129.827 125.006 95.562  1.00 157.31 ? 97  HIS A NE2 1 
ATOM   368  N N   . GLY A 1 98  ? 136.474 124.004 95.428  1.00 111.70 ? 98  GLY A N   1 
ATOM   369  C CA  . GLY A 1 98  ? 137.917 124.116 95.602  1.00 129.88 ? 98  GLY A CA  1 
ATOM   370  C C   . GLY A 1 98  ? 138.366 124.116 97.064  1.00 152.51 ? 98  GLY A C   1 
ATOM   371  O O   . GLY A 1 98  ? 139.557 124.279 97.332  1.00 180.59 ? 98  GLY A O   1 
ATOM   372  N N   . ARG A 1 99  ? 137.415 123.926 97.997  1.00 157.26 ? 99  ARG A N   1 
ATOM   373  C CA  . ARG A 1 99  ? 137.675 123.919 99.437  1.00 140.40 ? 99  ARG A CA  1 
ATOM   374  C C   . ARG A 1 99  ? 136.892 122.773 100.087 1.00 119.67 ? 99  ARG A C   1 
ATOM   375  O O   . ARG A 1 99  ? 135.745 122.518 99.715  1.00 118.53 ? 99  ARG A O   1 
ATOM   376  C CB  . ARG A 1 99  ? 137.294 125.271 100.056 1.00 156.30 ? 99  ARG A CB  1 
ATOM   377  C CG  . ARG A 1 99  ? 135.849 125.694 99.819  1.00 176.35 ? 99  ARG A CG  1 
ATOM   378  C CD  . ARG A 1 99  ? 135.530 127.086 100.328 1.00 187.84 ? 99  ARG A CD  1 
ATOM   379  N NE  . ARG A 1 99  ? 134.095 127.342 100.264 1.00 202.23 ? 99  ARG A NE  1 
ATOM   380  C CZ  . ARG A 1 99  ? 133.492 128.094 99.347  1.00 218.12 ? 99  ARG A CZ  1 
ATOM   381  N NH1 . ARG A 1 99  ? 132.179 128.246 99.375  1.00 210.89 ? 99  ARG A NH1 1 
ATOM   382  N NH2 . ARG A 1 99  ? 134.197 128.689 98.398  1.00 227.68 ? 99  ARG A NH2 1 
ATOM   383  N N   . PRO A 1 100 ? 137.476 122.004 101.040 1.00 123.85 ? 100 PRO A N   1 
ATOM   384  C CA  . PRO A 1 100 ? 136.783 120.852 101.632 1.00 128.02 ? 100 PRO A CA  1 
ATOM   385  C C   . PRO A 1 100 ? 135.500 121.202 102.385 1.00 120.59 ? 100 PRO A C   1 
ATOM   386  O O   . PRO A 1 100 ? 135.399 122.273 102.985 1.00 123.18 ? 100 PRO A O   1 
ATOM   387  C CB  . PRO A 1 100 ? 137.806 120.251 102.608 1.00 144.19 ? 100 PRO A CB  1 
ATOM   388  C CG  . PRO A 1 100 ? 139.148 120.775 102.128 1.00 154.37 ? 100 PRO A CG  1 
ATOM   389  C CD  . PRO A 1 100 ? 138.851 122.143 101.540 1.00 144.23 ? 100 PRO A CD  1 
ATOM   390  N N   . ILE A 1 101 ? 134.526 120.278 102.347 1.00 106.05 ? 101 ILE A N   1 
ATOM   391  C CA  . ILE A 1 101 ? 133.260 120.443 103.045 1.00 91.63  ? 101 ILE A CA  1 
ATOM   392  C C   . ILE A 1 101 ? 133.480 120.199 104.538 1.00 101.05 ? 101 ILE A C   1 
ATOM   393  O O   . ILE A 1 101 ? 134.236 119.304 104.921 1.00 115.20 ? 101 ILE A O   1 
ATOM   394  C CB  . ILE A 1 101 ? 132.176 119.514 102.445 1.00 83.14  ? 101 ILE A CB  1 
ATOM   395  C CG1 . ILE A 1 101 ? 130.762 119.944 102.834 1.00 79.59  ? 101 ILE A CG1 1 
ATOM   396  C CG2 . ILE A 1 101 ? 132.417 118.055 102.793 1.00 95.16  ? 101 ILE A CG2 1 
ATOM   397  C CD1 . ILE A 1 101 ? 129.677 119.241 102.079 1.00 82.69  ? 101 ILE A CD1 1 
ATOM   398  N N   . ASP A 1 102 ? 132.803 121.004 105.380 1.00 109.38 ? 102 ASP A N   1 
ATOM   399  C CA  . ASP A 1 102 ? 132.875 120.875 106.831 1.00 108.10 ? 102 ASP A CA  1 
ATOM   400  C C   . ASP A 1 102 ? 131.743 119.979 107.345 1.00 101.97 ? 102 ASP A C   1 
ATOM   401  O O   . ASP A 1 102 ? 130.669 119.900 106.741 1.00 130.34 ? 102 ASP A O   1 
ATOM   402  C CB  . ASP A 1 102 ? 132.946 122.240 107.526 1.00 129.02 ? 102 ASP A CB  1 
ATOM   403  C CG  . ASP A 1 102 ? 132.125 123.381 106.939 1.00 150.19 ? 102 ASP A CG  1 
ATOM   404  O OD1 . ASP A 1 102 ? 131.239 123.126 106.101 1.00 136.13 ? 102 ASP A OD1 1 
ATOM   405  O OD2 . ASP A 1 102 ? 132.385 124.541 107.337 1.00 185.21 ? 102 ASP A OD2 1 
ATOM   406  N N   . PRO A 1 103 ? 131.941 119.262 108.477 1.00 99.34  ? 103 PRO A N   1 
ATOM   407  C CA  . PRO A 1 103 ? 130.986 118.255 108.949 1.00 112.73 ? 103 PRO A CA  1 
ATOM   408  C C   . PRO A 1 103 ? 129.531 118.691 109.109 1.00 111.26 ? 103 PRO A C   1 
ATOM   409  O O   . PRO A 1 103 ? 128.629 117.880 108.887 1.00 125.58 ? 103 PRO A O   1 
ATOM   410  C CB  . PRO A 1 103 ? 131.550 117.844 110.318 1.00 133.75 ? 103 PRO A CB  1 
ATOM   411  C CG  . PRO A 1 103 ? 133.035 118.083 110.180 1.00 136.93 ? 103 PRO A CG  1 
ATOM   412  C CD  . PRO A 1 103 ? 133.131 119.336 109.334 1.00 118.78 ? 103 PRO A CD  1 
ATOM   413  N N   . ASP A 1 104 ? 129.307 119.964 109.481 1.00 101.95 ? 104 ASP A N   1 
ATOM   414  C CA  . ASP A 1 104 ? 127.969 120.475 109.737 1.00 98.23  ? 104 ASP A CA  1 
ATOM   415  C C   . ASP A 1 104 ? 127.232 120.768 108.430 1.00 78.22  ? 104 ASP A C   1 
ATOM   416  O O   . ASP A 1 104 ? 126.013 120.587 108.370 1.00 73.80  ? 104 ASP A O   1 
ATOM   417  C CB  . ASP A 1 104 ? 128.031 121.680 110.677 1.00 135.68 ? 104 ASP A CB  1 
ATOM   418  C CG  . ASP A 1 104 ? 128.364 121.314 112.121 1.00 163.49 ? 104 ASP A CG  1 
ATOM   419  O OD1 . ASP A 1 104 ? 128.360 120.099 112.446 1.00 175.11 ? 104 ASP A OD1 1 
ATOM   420  O OD2 . ASP A 1 104 ? 128.626 122.243 112.913 1.00 168.31 ? 104 ASP A OD2 1 
ATOM   421  N N   . THR A 1 105 ? 127.957 121.214 107.389 1.00 73.40  ? 105 THR A N   1 
ATOM   422  C CA  . THR A 1 105 ? 127.361 121.421 106.073 1.00 62.98  ? 105 THR A CA  1 
ATOM   423  C C   . THR A 1 105 ? 126.922 120.077 105.501 1.00 64.28  ? 105 THR A C   1 
ATOM   424  O O   . THR A 1 105 ? 125.826 119.972 104.955 1.00 61.96  ? 105 THR A O   1 
ATOM   425  C CB  . THR A 1 105 ? 128.317 122.127 105.100 1.00 68.55  ? 105 THR A CB  1 
ATOM   426  O OG1 . THR A 1 105 ? 128.690 123.383 105.667 1.00 81.12  ? 105 THR A OG1 1 
ATOM   427  C CG2 . THR A 1 105 ? 127.722 122.370 103.728 1.00 77.39  ? 105 THR A CG2 1 
ATOM   428  N N   . LEU A 1 106 ? 127.798 119.059 105.592 1.00 66.57  ? 106 LEU A N   1 
ATOM   429  C CA  . LEU A 1 106 ? 127.519 117.737 105.064 1.00 62.70  ? 106 LEU A CA  1 
ATOM   430  C C   . LEU A 1 106 ? 126.368 117.064 105.825 1.00 67.09  ? 106 LEU A C   1 
ATOM   431  O O   . LEU A 1 106 ? 125.592 116.306 105.231 1.00 67.98  ? 106 LEU A O   1 
ATOM   432  C CB  . LEU A 1 106 ? 128.818 116.931 105.132 1.00 61.01  ? 106 LEU A CB  1 
ATOM   433  C CG  . LEU A 1 106 ? 128.766 115.501 104.589 1.00 57.64  ? 106 LEU A CG  1 
ATOM   434  C CD1 . LEU A 1 106 ? 128.282 115.450 103.177 1.00 51.82  ? 106 LEU A CD1 1 
ATOM   435  C CD2 . LEU A 1 106 ? 130.150 114.873 104.644 1.00 66.45  ? 106 LEU A CD2 1 
ATOM   436  N N   . THR A 1 107 ? 126.243 117.325 107.135 1.00 66.46  ? 107 THR A N   1 
ATOM   437  C CA  . THR A 1 107 ? 125.130 116.821 107.935 1.00 71.33  ? 107 THR A CA  1 
ATOM   438  C C   . THR A 1 107 ? 123.813 117.501 107.541 1.00 62.71  ? 107 THR A C   1 
ATOM   439  O O   . THR A 1 107 ? 122.772 116.850 107.488 1.00 67.36  ? 107 THR A O   1 
ATOM   440  C CB  . THR A 1 107 ? 125.390 116.963 109.440 1.00 74.59  ? 107 THR A CB  1 
ATOM   441  O OG1 . THR A 1 107 ? 126.614 116.290 109.752 1.00 82.95  ? 107 THR A OG1 1 
ATOM   442  C CG2 . THR A 1 107 ? 124.264 116.408 110.292 1.00 69.87  ? 107 THR A CG2 1 
ATOM   443  N N   . LEU A 1 108 ? 123.856 118.798 107.238 1.00 60.54  ? 108 LEU A N   1 
ATOM   444  C CA  . LEU A 1 108 ? 122.668 119.502 106.780 1.00 71.21  ? 108 LEU A CA  1 
ATOM   445  C C   . LEU A 1 108 ? 122.229 119.029 105.379 1.00 67.74  ? 108 LEU A C   1 
ATOM   446  O O   . LEU A 1 108 ? 121.037 118.826 105.175 1.00 73.30  ? 108 LEU A O   1 
ATOM   447  C CB  . LEU A 1 108 ? 122.965 121.009 106.815 1.00 70.85  ? 108 LEU A CB  1 
ATOM   448  C CG  . LEU A 1 108 ? 121.889 121.953 106.315 1.00 65.76  ? 108 LEU A CG  1 
ATOM   449  C CD1 . LEU A 1 108 ? 120.606 121.815 107.096 1.00 64.67  ? 108 LEU A CD1 1 
ATOM   450  C CD2 . LEU A 1 108 ? 122.424 123.370 106.456 1.00 88.72  ? 108 LEU A CD2 1 
ATOM   451  N N   . LEU A 1 109 ? 123.145 118.865 104.407 1.00 51.78  ? 109 LEU A N   1 
ATOM   452  C CA  . LEU A 1 109 ? 122.791 118.393 103.081 1.00 51.42  ? 109 LEU A CA  1 
ATOM   453  C C   . LEU A 1 109 ? 122.137 117.014 103.137 1.00 51.55  ? 109 LEU A C   1 
ATOM   454  O O   . LEU A 1 109 ? 121.252 116.713 102.331 1.00 56.21  ? 109 LEU A O   1 
ATOM   455  C CB  . LEU A 1 109 ? 124.037 118.328 102.189 1.00 54.40  ? 109 LEU A CB  1 
ATOM   456  C CG  . LEU A 1 109 ? 124.585 119.648 101.688 1.00 56.28  ? 109 LEU A CG  1 
ATOM   457  C CD1 . LEU A 1 109 ? 125.851 119.435 100.882 1.00 59.35  ? 109 LEU A CD1 1 
ATOM   458  C CD2 . LEU A 1 109 ? 123.537 120.293 100.827 1.00 61.73  ? 109 LEU A CD2 1 
ATOM   459  N N   . TRP A 1 110 ? 122.609 116.148 104.037 1.00 55.75  ? 110 TRP A N   1 
ATOM   460  C CA  . TRP A 1 110 ? 122.031 114.826 104.174 1.00 52.43  ? 110 TRP A CA  1 
ATOM   461  C C   . TRP A 1 110 ? 120.650 114.920 104.840 1.00 54.55  ? 110 TRP A C   1 
ATOM   462  O O   . TRP A 1 110 ? 119.701 114.268 104.414 1.00 54.56  ? 110 TRP A O   1 
ATOM   463  C CB  . TRP A 1 110 ? 122.988 113.894 104.926 1.00 53.56  ? 110 TRP A CB  1 
ATOM   464  C CG  . TRP A 1 110 ? 122.400 112.514 105.050 1.00 59.32  ? 110 TRP A CG  1 
ATOM   465  C CD1 . TRP A 1 110 ? 122.023 111.868 106.196 1.00 57.83  ? 110 TRP A CD1 1 
ATOM   466  C CD2 . TRP A 1 110 ? 122.004 111.668 103.953 1.00 57.41  ? 110 TRP A CD2 1 
ATOM   467  N NE1 . TRP A 1 110 ? 121.446 110.675 105.888 1.00 58.20  ? 110 TRP A NE1 1 
ATOM   468  C CE2 . TRP A 1 110 ? 121.412 110.529 104.519 1.00 64.26  ? 110 TRP A CE2 1 
ATOM   469  C CE3 . TRP A 1 110 ? 122.072 111.758 102.560 1.00 67.05  ? 110 TRP A CE3 1 
ATOM   470  C CZ2 . TRP A 1 110 ? 120.915 109.490 103.728 1.00 68.56  ? 110 TRP A CZ2 1 
ATOM   471  C CZ3 . TRP A 1 110 ? 121.560 110.736 101.786 1.00 60.48  ? 110 TRP A CZ3 1 
ATOM   472  C CH2 . TRP A 1 110 ? 120.980 109.625 102.363 1.00 54.26  ? 110 TRP A CH2 1 
ATOM   473  N N   . SER A 1 111 ? 120.508 115.761 105.871 1.00 58.54  ? 111 SER A N   1 
ATOM   474  C CA  . SER A 1 111 ? 119.229 115.981 106.528 1.00 59.32  ? 111 SER A CA  1 
ATOM   475  C C   . SER A 1 111 ? 118.176 116.540 105.564 1.00 60.04  ? 111 SER A C   1 
ATOM   476  O O   . SER A 1 111 ? 117.006 116.188 105.657 1.00 62.56  ? 111 SER A O   1 
ATOM   477  C CB  . SER A 1 111 ? 119.420 116.908 107.695 1.00 62.22  ? 111 SER A CB  1 
ATOM   478  O OG  . SER A 1 111 ? 120.379 116.401 108.598 1.00 74.43  ? 111 SER A OG  1 
ATOM   479  N N   . VAL A 1 112 ? 118.573 117.463 104.680 1.00 57.70  ? 112 VAL A N   1 
ATOM   480  C CA  . VAL A 1 112 ? 117.703 118.007 103.644 1.00 54.56  ? 112 VAL A CA  1 
ATOM   481  C C   . VAL A 1 112 ? 117.363 116.936 102.594 1.00 56.37  ? 112 VAL A C   1 
ATOM   482  O O   . VAL A 1 112 ? 116.215 116.818 102.208 1.00 59.99  ? 112 VAL A O   1 
ATOM   483  C CB  . VAL A 1 112 ? 118.326 119.259 103.007 1.00 59.04  ? 112 VAL A CB  1 
ATOM   484  C CG1 . VAL A 1 112 ? 117.642 119.667 101.722 1.00 61.75  ? 112 VAL A CG1 1 
ATOM   485  C CG2 . VAL A 1 112 ? 118.326 120.411 103.985 1.00 72.02  ? 112 VAL A CG2 1 
ATOM   486  N N   . THR A 1 113 ? 118.322 116.114 102.155 1.00 61.59  ? 113 THR A N   1 
ATOM   487  C CA  . THR A 1 113 ? 118.034 115.038 101.218 1.00 55.53  ? 113 THR A CA  1 
ATOM   488  C C   . THR A 1 113 ? 116.983 114.087 101.790 1.00 50.61  ? 113 THR A C   1 
ATOM   489  O O   . THR A 1 113 ? 116.078 113.666 101.084 1.00 63.24  ? 113 THR A O   1 
ATOM   490  C CB  . THR A 1 113 ? 119.304 114.243 100.862 1.00 59.88  ? 113 THR A CB  1 
ATOM   491  O OG1 . THR A 1 113 ? 120.277 115.144 100.334 1.00 60.94  ? 113 THR A OG1 1 
ATOM   492  C CG2 . THR A 1 113 ? 119.057 113.134 99.863  1.00 62.96  ? 113 THR A CG2 1 
ATOM   493  N N   . VAL A 1 114 ? 117.140 113.673 103.044 1.00 54.67  ? 114 VAL A N   1 
ATOM   494  C CA  . VAL A 1 114 ? 116.226 112.742 103.702 1.00 59.34  ? 114 VAL A CA  1 
ATOM   495  C C   . VAL A 1 114 ? 114.824 113.335 103.854 1.00 51.54  ? 114 VAL A C   1 
ATOM   496  O O   . VAL A 1 114 ? 113.854 112.689 103.491 1.00 53.13  ? 114 VAL A O   1 
ATOM   497  C CB  . VAL A 1 114 ? 116.803 112.291 105.061 1.00 57.75  ? 114 VAL A CB  1 
ATOM   498  C CG1 . VAL A 1 114 ? 115.781 111.644 105.966 1.00 50.59  ? 114 VAL A CG1 1 
ATOM   499  C CG2 . VAL A 1 114 ? 117.989 111.364 104.854 1.00 54.84  ? 114 VAL A CG2 1 
ATOM   500  N N   . SER A 1 115 ? 114.727 114.576 104.344 1.00 57.80  ? 115 SER A N   1 
ATOM   501  C CA  . SER A 1 115 ? 113.468 115.163 104.781 1.00 60.34  ? 115 SER A CA  1 
ATOM   502  C C   . SER A 1 115 ? 112.683 115.903 103.687 1.00 53.24  ? 115 SER A C   1 
ATOM   503  O O   . SER A 1 115 ? 111.487 116.068 103.848 1.00 57.79  ? 115 SER A O   1 
ATOM   504  C CB  . SER A 1 115 ? 113.729 116.076 105.956 1.00 68.23  ? 115 SER A CB  1 
ATOM   505  O OG  . SER A 1 115 ? 114.529 117.172 105.569 1.00 67.24  ? 115 SER A OG  1 
ATOM   506  N N   . ILE A 1 116 ? 113.312 116.358 102.596 1.00 55.95  ? 116 ILE A N   1 
ATOM   507  C CA  . ILE A 1 116 ? 112.631 117.123 101.547 1.00 59.75  ? 116 ILE A CA  1 
ATOM   508  C C   . ILE A 1 116 ? 111.461 116.329 100.934 1.00 60.55  ? 116 ILE A C   1 
ATOM   509  O O   . ILE A 1 116 ? 110.504 116.915 100.430 1.00 71.14  ? 116 ILE A O   1 
ATOM   510  C CB  . ILE A 1 116 ? 113.614 117.596 100.455 1.00 65.98  ? 116 ILE A CB  1 
ATOM   511  C CG1 . ILE A 1 116 ? 113.050 118.723 99.598  1.00 73.20  ? 116 ILE A CG1 1 
ATOM   512  C CG2 . ILE A 1 116 ? 114.087 116.449 99.591  1.00 67.88  ? 116 ILE A CG2 1 
ATOM   513  C CD1 . ILE A 1 116 ? 112.841 120.003 100.418 1.00 93.13  ? 116 ILE A CD1 1 
ATOM   514  N N   . PHE A 1 117 ? 111.514 115.002 101.044 1.00 57.71  ? 117 PHE A N   1 
ATOM   515  C CA  . PHE A 1 117 ? 110.440 114.101 100.672 1.00 57.66  ? 117 PHE A CA  1 
ATOM   516  C C   . PHE A 1 117 ? 109.110 114.461 101.341 1.00 64.70  ? 117 PHE A C   1 
ATOM   517  O O   . PHE A 1 117 ? 108.048 114.293 100.734 1.00 78.69  ? 117 PHE A O   1 
ATOM   518  C CB  . PHE A 1 117 ? 110.898 112.697 101.058 1.00 60.17  ? 117 PHE A CB  1 
ATOM   519  C CG  . PHE A 1 117 ? 109.936 111.563 100.829 1.00 69.16  ? 117 PHE A CG  1 
ATOM   520  C CD1 . PHE A 1 117 ? 109.769 110.987 99.571  1.00 74.05  ? 117 PHE A CD1 1 
ATOM   521  C CD2 . PHE A 1 117 ? 109.241 111.040 101.902 1.00 78.32  ? 117 PHE A CD2 1 
ATOM   522  C CE1 . PHE A 1 117 ? 108.912 109.916 99.398  1.00 88.60  ? 117 PHE A CE1 1 
ATOM   523  C CE2 . PHE A 1 117 ? 108.383 109.969 101.719 1.00 95.61  ? 117 PHE A CE2 1 
ATOM   524  C CZ  . PHE A 1 117 ? 108.208 109.419 100.468 1.00 95.16  ? 117 PHE A CZ  1 
ATOM   525  N N   . ALA A 1 118 ? 109.146 114.951 102.594 1.00 61.57  ? 118 ALA A N   1 
ATOM   526  C CA  . ALA A 1 118 ? 107.940 115.293 103.331 1.00 60.33  ? 118 ALA A CA  1 
ATOM   527  C C   . ALA A 1 118 ? 107.331 116.613 102.849 1.00 60.23  ? 118 ALA A C   1 
ATOM   528  O O   . ALA A 1 118 ? 106.108 116.789 102.933 1.00 66.10  ? 118 ALA A O   1 
ATOM   529  C CB  . ALA A 1 118 ? 108.251 115.317 104.810 1.00 67.81  ? 118 ALA A CB  1 
ATOM   530  N N   . ILE A 1 119 ? 108.161 117.544 102.348 1.00 56.49  ? 119 ILE A N   1 
ATOM   531  C CA  . ILE A 1 119 ? 107.668 118.758 101.698 1.00 59.23  ? 119 ILE A CA  1 
ATOM   532  C C   . ILE A 1 119 ? 107.069 118.394 100.333 1.00 58.37  ? 119 ILE A C   1 
ATOM   533  O O   . ILE A 1 119 ? 106.087 118.994 99.902  1.00 65.13  ? 119 ILE A O   1 
ATOM   534  C CB  . ILE A 1 119 ? 108.773 119.827 101.610 1.00 60.20  ? 119 ILE A CB  1 
ATOM   535  C CG1 . ILE A 1 119 ? 109.283 120.213 103.001 1.00 74.90  ? 119 ILE A CG1 1 
ATOM   536  C CG2 . ILE A 1 119 ? 108.288 121.047 100.840 1.00 70.22  ? 119 ILE A CG2 1 
ATOM   537  C CD1 . ILE A 1 119 ? 108.216 120.840 103.902 1.00 89.18  ? 119 ILE A CD1 1 
ATOM   538  N N   . GLY A 1 120 ? 107.646 117.404 99.654  1.00 55.06  ? 120 GLY A N   1 
ATOM   539  C CA  . GLY A 1 120 ? 107.031 116.813 98.484  1.00 55.87  ? 120 GLY A CA  1 
ATOM   540  C C   . GLY A 1 120 ? 105.642 116.270 98.780  1.00 56.18  ? 120 GLY A C   1 
ATOM   541  O O   . GLY A 1 120 ? 104.689 116.592 98.076  1.00 58.64  ? 120 GLY A O   1 
ATOM   542  N N   . GLY A 1 121 ? 105.526 115.459 99.836  1.00 57.33  ? 121 GLY A N   1 
ATOM   543  C CA  . GLY A 1 121 ? 104.254 114.862 100.222 1.00 59.24  ? 121 GLY A CA  1 
ATOM   544  C C   . GLY A 1 121 ? 103.164 115.884 100.546 1.00 55.32  ? 121 GLY A C   1 
ATOM   545  O O   . GLY A 1 121 ? 101.993 115.640 100.264 1.00 61.13  ? 121 GLY A O   1 
ATOM   546  N N   . LEU A 1 122 ? 103.548 117.024 101.130 1.00 53.43  ? 122 LEU A N   1 
ATOM   547  C CA  . LEU A 1 122 ? 102.618 118.108 101.409 1.00 52.69  ? 122 LEU A CA  1 
ATOM   548  C C   . LEU A 1 122 ? 102.103 118.734 100.107 1.00 51.82  ? 122 LEU A C   1 
ATOM   549  O O   . LEU A 1 122 ? 100.899 118.965 99.975  1.00 55.40  ? 122 LEU A O   1 
ATOM   550  C CB  . LEU A 1 122 ? 103.327 119.128 102.311 1.00 60.13  ? 122 LEU A CB  1 
ATOM   551  C CG  . LEU A 1 122 ? 102.521 120.357 102.735 1.00 63.68  ? 122 LEU A CG  1 
ATOM   552  C CD1 . LEU A 1 122 ? 101.243 119.955 103.424 1.00 74.47  ? 122 LEU A CD1 1 
ATOM   553  C CD2 . LEU A 1 122 ? 103.319 121.219 103.683 1.00 67.97  ? 122 LEU A CD2 1 
ATOM   554  N N   . VAL A 1 123 ? 102.993 118.991 99.136  1.00 50.93  ? 123 VAL A N   1 
ATOM   555  C CA  . VAL A 1 123 ? 102.589 119.471 97.824  1.00 54.90  ? 123 VAL A CA  1 
ATOM   556  C C   . VAL A 1 123 ? 101.671 118.446 97.150  1.00 56.13  ? 123 VAL A C   1 
ATOM   557  O O   . VAL A 1 123 ? 100.640 118.814 96.601  1.00 67.24  ? 123 VAL A O   1 
ATOM   558  C CB  . VAL A 1 123 ? 103.808 119.830 96.949  1.00 60.73  ? 123 VAL A CB  1 
ATOM   559  C CG1 . VAL A 1 123 ? 103.416 120.094 95.502  1.00 65.36  ? 123 VAL A CG1 1 
ATOM   560  C CG2 . VAL A 1 123 ? 104.550 121.024 97.504  1.00 66.38  ? 123 VAL A CG2 1 
ATOM   561  N N   . GLY A 1 124 ? 102.009 117.153 97.200  1.00 63.18  ? 124 GLY A N   1 
ATOM   562  C CA  . GLY A 1 124 ? 101.156 116.119 96.633  1.00 60.61  ? 124 GLY A CA  1 
ATOM   563  C C   . GLY A 1 124 ? 99.779  116.031 97.294  1.00 64.84  ? 124 GLY A C   1 
ATOM   564  O O   . GLY A 1 124 ? 98.796  115.814 96.613  1.00 76.95  ? 124 GLY A O   1 
ATOM   565  N N   . THR A 1 125 ? 99.688  116.257 98.611  1.00 71.65  ? 125 THR A N   1 
ATOM   566  C CA  . THR A 1 125 ? 98.416  116.271 99.336  1.00 64.52  ? 125 THR A CA  1 
ATOM   567  C C   . THR A 1 125 ? 97.529  117.457 98.939  1.00 64.20  ? 125 THR A C   1 
ATOM   568  O O   . THR A 1 125 ? 96.310  117.364 99.048  1.00 78.56  ? 125 THR A O   1 
ATOM   569  C CB  . THR A 1 125 ? 98.663  116.279 100.848 1.00 63.46  ? 125 THR A CB  1 
ATOM   570  O OG1 . THR A 1 125 ? 99.368  115.085 101.168 1.00 61.50  ? 125 THR A OG1 1 
ATOM   571  C CG2 . THR A 1 125 ? 97.416  116.320 101.703 1.00 74.65  ? 125 THR A CG2 1 
ATOM   572  N N   . LEU A 1 126 ? 98.123  118.566 98.474  1.00 59.86  ? 126 LEU A N   1 
ATOM   573  C CA  . LEU A 1 126 ? 97.380  119.745 98.049  1.00 66.11  ? 126 LEU A CA  1 
ATOM   574  C C   . LEU A 1 126 ? 97.030  119.687 96.557  1.00 72.98  ? 126 LEU A C   1 
ATOM   575  O O   . LEU A 1 126 ? 95.965  120.155 96.158  1.00 84.70  ? 126 LEU A O   1 
ATOM   576  C CB  . LEU A 1 126 ? 98.199  120.998 98.387  1.00 75.55  ? 126 LEU A CB  1 
ATOM   577  C CG  . LEU A 1 126 ? 98.403  121.240 99.885  1.00 91.32  ? 126 LEU A CG  1 
ATOM   578  C CD1 . LEU A 1 126 ? 99.439  122.324 100.118 1.00 106.98 ? 126 LEU A CD1 1 
ATOM   579  C CD2 . LEU A 1 126 ? 97.096  121.586 100.593 1.00 92.53  ? 126 LEU A CD2 1 
ATOM   580  N N   . ILE A 1 127 ? 97.885  119.085 95.716  1.00 82.60  ? 127 ILE A N   1 
ATOM   581  C CA  . ILE A 1 127 ? 97.614  118.918 94.289  1.00 77.99  ? 127 ILE A CA  1 
ATOM   582  C C   . ILE A 1 127 ? 96.320  118.127 94.056  1.00 86.75  ? 127 ILE A C   1 
ATOM   583  O O   . ILE A 1 127 ? 95.570  118.459 93.143  1.00 99.44  ? 127 ILE A O   1 
ATOM   584  C CB  . ILE A 1 127 ? 98.840  118.289 93.594  1.00 87.87  ? 127 ILE A CB  1 
ATOM   585  C CG1 . ILE A 1 127 ? 99.918  119.344 93.380  1.00 113.21 ? 127 ILE A CG1 1 
ATOM   586  C CG2 . ILE A 1 127 ? 98.495  117.606 92.282  1.00 103.06 ? 127 ILE A CG2 1 
ATOM   587  C CD1 . ILE A 1 127 ? 101.264 118.767 92.968  1.00 134.23 ? 127 ILE A CD1 1 
ATOM   588  N N   . VAL A 1 128 ? 96.007  117.130 94.897  1.00 87.92  ? 128 VAL A N   1 
ATOM   589  C CA  . VAL A 1 128 ? 94.809  116.308 94.747  1.00 92.24  ? 128 VAL A CA  1 
ATOM   590  C C   . VAL A 1 128 ? 93.519  117.134 94.866  1.00 118.65 ? 128 VAL A C   1 
ATOM   591  O O   . VAL A 1 128 ? 92.512  116.772 94.244  1.00 137.99 ? 128 VAL A O   1 
ATOM   592  C CB  . VAL A 1 128 ? 94.840  115.125 95.733  1.00 93.01  ? 128 VAL A CB  1 
ATOM   593  C CG1 . VAL A 1 128 ? 93.533  114.353 95.838  1.00 108.30 ? 128 VAL A CG1 1 
ATOM   594  C CG2 . VAL A 1 128 ? 95.939  114.173 95.341  1.00 100.59 ? 128 VAL A CG2 1 
ATOM   595  N N   . LYS A 1 129 ? 93.541  118.261 95.603  1.00 126.16 ? 129 LYS A N   1 
ATOM   596  C CA  . LYS A 1 129 ? 92.405  119.170 95.687  1.00 142.47 ? 129 LYS A CA  1 
ATOM   597  C C   . LYS A 1 129 ? 92.189  119.899 94.354  1.00 140.44 ? 129 LYS A C   1 
ATOM   598  O O   . LYS A 1 129 ? 91.045  120.076 93.934  1.00 148.65 ? 129 LYS A O   1 
ATOM   599  C CB  . LYS A 1 129 ? 92.591  120.183 96.827  1.00 166.13 ? 129 LYS A CB  1 
ATOM   600  C CG  . LYS A 1 129 ? 92.287  119.679 98.234  1.00 174.07 ? 129 LYS A CG  1 
ATOM   601  C CD  . LYS A 1 129 ? 93.057  118.439 98.644  1.00 193.31 ? 129 LYS A CD  1 
ATOM   602  C CE  . LYS A 1 129 ? 92.860  118.085 100.104 1.00 210.26 ? 129 LYS A CE  1 
ATOM   603  N NZ  . LYS A 1 129 ? 93.573  116.838 100.474 1.00 216.93 ? 129 LYS A NZ  1 
ATOM   604  N N   . MET A 1 130 ? 93.278  120.326 93.691  1.00 125.87 ? 130 MET A N   1 
ATOM   605  C CA  . MET A 1 130 ? 93.222  121.020 92.411  1.00 130.30 ? 130 MET A CA  1 
ATOM   606  C C   . MET A 1 130 ? 92.804  120.079 91.276  1.00 130.87 ? 130 MET A C   1 
ATOM   607  O O   . MET A 1 130 ? 92.052  120.495 90.395  1.00 162.46 ? 130 MET A O   1 
ATOM   608  C CB  . MET A 1 130 ? 94.586  121.631 92.071  1.00 162.31 ? 130 MET A CB  1 
ATOM   609  C CG  . MET A 1 130 ? 95.009  122.753 93.004  1.00 190.16 ? 130 MET A CG  1 
ATOM   610  S SD  . MET A 1 130 ? 96.500  123.640 92.436  1.00 232.76 ? 130 MET A SD  1 
ATOM   611  C CE  . MET A 1 130 ? 97.779  122.397 92.637  1.00 239.39 ? 130 MET A CE  1 
ATOM   612  N N   . ILE A 1 131 ? 93.309  118.832 91.267  1.00 128.93 ? 131 ILE A N   1 
ATOM   613  C CA  . ILE A 1 131 ? 92.948  117.827 90.270  1.00 122.22 ? 131 ILE A CA  1 
ATOM   614  C C   . ILE A 1 131 ? 91.472  117.456 90.437  1.00 151.48 ? 131 ILE A C   1 
ATOM   615  O O   . ILE A 1 131 ? 90.708  117.577 89.487  1.00 176.85 ? 131 ILE A O   1 
ATOM   616  C CB  . ILE A 1 131 ? 93.880  116.594 90.341  1.00 118.65 ? 131 ILE A CB  1 
ATOM   617  C CG1 . ILE A 1 131 ? 95.311  116.956 89.938  1.00 120.87 ? 131 ILE A CG1 1 
ATOM   618  C CG2 . ILE A 1 131 ? 93.360  115.431 89.499  1.00 123.11 ? 131 ILE A CG2 1 
ATOM   619  C CD1 . ILE A 1 131 ? 96.312  115.823 90.068  1.00 125.78 ? 131 ILE A CD1 1 
ATOM   620  N N   . GLY A 1 132 ? 91.078  116.987 91.630  1.00 167.24 ? 132 GLY A N   1 
ATOM   621  C CA  . GLY A 1 132 ? 89.682  116.737 91.978  1.00 182.70 ? 132 GLY A CA  1 
ATOM   622  C C   . GLY A 1 132 ? 88.872  116.021 90.892  1.00 189.68 ? 132 GLY A C   1 
ATOM   623  O O   . GLY A 1 132 ? 89.222  114.915 90.480  1.00 194.71 ? 132 GLY A O   1 
ATOM   624  N N   . LYS A 1 133 ? 87.790  116.683 90.441  1.00 180.71 ? 133 LYS A N   1 
ATOM   625  C CA  . LYS A 1 133 ? 86.793  116.150 89.521  1.00 183.82 ? 133 LYS A CA  1 
ATOM   626  C C   . LYS A 1 133 ? 87.346  115.855 88.116  1.00 161.94 ? 133 LYS A C   1 
ATOM   627  O O   . LYS A 1 133 ? 86.723  115.101 87.367  1.00 163.35 ? 133 LYS A O   1 
ATOM   628  C CB  . LYS A 1 133 ? 85.653  117.176 89.471  1.00 224.84 ? 133 LYS A CB  1 
ATOM   629  C CG  . LYS A 1 133 ? 84.451  116.830 88.605  1.00 252.48 ? 133 LYS A CG  1 
ATOM   630  C CD  . LYS A 1 133 ? 83.327  117.832 88.754  1.00 258.67 ? 133 LYS A CD  1 
ATOM   631  C CE  . LYS A 1 133 ? 82.162  117.565 87.826  1.00 259.76 ? 133 LYS A CE  1 
ATOM   632  N NZ  . LYS A 1 133 ? 81.084  118.565 88.004  1.00 256.58 ? 133 LYS A NZ  1 
ATOM   633  N N   . VAL A 1 134 ? 88.509  116.423 87.742  1.00 133.53 ? 134 VAL A N   1 
ATOM   634  C CA  . VAL A 1 134 ? 88.991  116.448 86.358  1.00 120.04 ? 134 VAL A CA  1 
ATOM   635  C C   . VAL A 1 134 ? 89.399  115.056 85.831  1.00 132.24 ? 134 VAL A C   1 
ATOM   636  O O   . VAL A 1 134 ? 88.965  114.688 84.733  1.00 134.51 ? 134 VAL A O   1 
ATOM   637  C CB  . VAL A 1 134 ? 90.132  117.470 86.195  1.00 108.12 ? 134 VAL A CB  1 
ATOM   638  C CG1 . VAL A 1 134 ? 90.733  117.491 84.794  1.00 115.27 ? 134 VAL A CG1 1 
ATOM   639  C CG2 . VAL A 1 134 ? 89.664  118.864 86.576  1.00 121.43 ? 134 VAL A CG2 1 
ATOM   640  N N   . LEU A 1 135 ? 90.229  114.283 86.559  1.00 104.36 ? 135 LEU A N   1 
ATOM   641  C CA  . LEU A 1 135 ? 90.720  113.004 86.055  1.00 96.30  ? 135 LEU A CA  1 
ATOM   642  C C   . LEU A 1 135 ? 89.880  111.801 86.515  1.00 108.01 ? 135 LEU A C   1 
ATOM   643  O O   . LEU A 1 135 ? 89.665  110.871 85.731  1.00 132.42 ? 135 LEU A O   1 
ATOM   644  C CB  . LEU A 1 135 ? 92.180  112.799 86.478  1.00 93.12  ? 135 LEU A CB  1 
ATOM   645  C CG  . LEU A 1 135 ? 93.207  113.579 85.678  1.00 109.36 ? 135 LEU A CG  1 
ATOM   646  C CD1 . LEU A 1 135 ? 94.604  113.312 86.227  1.00 121.43 ? 135 LEU A CD1 1 
ATOM   647  C CD2 . LEU A 1 135 ? 93.114  113.211 84.208  1.00 121.66 ? 135 LEU A CD2 1 
ATOM   648  N N   . GLY A 1 136 ? 89.446  111.770 87.777  1.00 90.99  ? 136 GLY A N   1 
ATOM   649  C CA  . GLY A 1 136 ? 88.903  110.534 88.329  1.00 88.81  ? 136 GLY A CA  1 
ATOM   650  C C   . GLY A 1 136 ? 89.989  109.706 89.021  1.00 87.25  ? 136 GLY A C   1 
ATOM   651  O O   . GLY A 1 136 ? 91.169  110.025 88.928  1.00 86.81  ? 136 GLY A O   1 
ATOM   652  N N   . ARG A 1 137 ? 89.591  108.642 89.744  1.00 89.18  ? 137 ARG A N   1 
ATOM   653  C CA  . ARG A 1 137 ? 90.476  108.032 90.730  1.00 78.45  ? 137 ARG A CA  1 
ATOM   654  C C   . ARG A 1 137 ? 91.517  107.146 90.042  1.00 82.09  ? 137 ARG A C   1 
ATOM   655  O O   . ARG A 1 137 ? 92.662  107.114 90.473  1.00 87.42  ? 137 ARG A O   1 
ATOM   656  C CB  . ARG A 1 137 ? 89.726  107.192 91.770  1.00 89.17  ? 137 ARG A CB  1 
ATOM   657  C CG  . ARG A 1 137 ? 88.501  107.823 92.414  1.00 99.76  ? 137 ARG A CG  1 
ATOM   658  C CD  . ARG A 1 137 ? 88.741  109.111 93.194  1.00 100.79 ? 137 ARG A CD  1 
ATOM   659  N NE  . ARG A 1 137 ? 87.520  109.462 93.917  1.00 104.63 ? 137 ARG A NE  1 
ATOM   660  C CZ  . ARG A 1 137 ? 86.632  110.388 93.565  1.00 122.12 ? 137 ARG A CZ  1 
ATOM   661  N NH1 . ARG A 1 137 ? 85.419  110.324 94.084  1.00 126.98 ? 137 ARG A NH1 1 
ATOM   662  N NH2 . ARG A 1 137 ? 86.898  111.314 92.653  1.00 127.54 ? 137 ARG A NH2 1 
ATOM   663  N N   . LYS A 1 138 ? 91.144  106.423 88.973  1.00 90.06  ? 138 LYS A N   1 
ATOM   664  C CA  . LYS A 1 138 ? 92.090  105.545 88.296  1.00 78.42  ? 138 LYS A CA  1 
ATOM   665  C C   . LYS A 1 138 ? 93.143  106.380 87.570  1.00 76.01  ? 138 LYS A C   1 
ATOM   666  O O   . LYS A 1 138 ? 94.335  106.139 87.737  1.00 88.14  ? 138 LYS A O   1 
ATOM   667  C CB  . LYS A 1 138 ? 91.385  104.602 87.309  1.00 71.03  ? 138 LYS A CB  1 
ATOM   668  C CG  . LYS A 1 138 ? 92.268  103.502 86.754  1.00 68.57  ? 138 LYS A CG  1 
ATOM   669  C CD  . LYS A 1 138 ? 91.562  102.593 85.765  1.00 75.32  ? 138 LYS A CD  1 
ATOM   670  C CE  . LYS A 1 138 ? 91.261  103.263 84.449  1.00 75.95  ? 138 LYS A CE  1 
ATOM   671  N NZ  . LYS A 1 138 ? 90.769  102.300 83.440  1.00 83.02  ? 138 LYS A NZ  1 
ATOM   672  N N   . HIS A 1 139 ? 92.712  107.340 86.738  1.00 73.07  ? 139 HIS A N   1 
ATOM   673  C CA  . HIS A 1 139 ? 93.609  108.128 85.914  1.00 64.88  ? 139 HIS A CA  1 
ATOM   674  C C   . HIS A 1 139 ? 94.530  109.004 86.760  1.00 73.99  ? 139 HIS A C   1 
ATOM   675  O O   . HIS A 1 139 ? 95.641  109.286 86.318  1.00 94.18  ? 139 HIS A O   1 
ATOM   676  C CB  . HIS A 1 139 ? 92.825  108.974 84.908  1.00 75.88  ? 139 HIS A CB  1 
ATOM   677  C CG  . HIS A 1 139 ? 92.253  108.162 83.807  1.00 96.01  ? 139 HIS A CG  1 
ATOM   678  N ND1 . HIS A 1 139 ? 91.121  107.382 83.887  1.00 117.98 ? 139 HIS A ND1 1 
ATOM   679  C CD2 . HIS A 1 139 ? 92.701  108.036 82.560  1.00 123.71 ? 139 HIS A CD2 1 
ATOM   680  C CE1 . HIS A 1 139 ? 90.912  106.798 82.715  1.00 138.68 ? 139 HIS A CE1 1 
ATOM   681  N NE2 . HIS A 1 139 ? 91.864  107.176 81.894  1.00 136.00 ? 139 HIS A NE2 1 
ATOM   682  N N   . THR A 1 140 ? 94.117  109.444 87.958  1.00 65.58  ? 140 THR A N   1 
ATOM   683  C CA  . THR A 1 140 ? 95.052  110.088 88.868  1.00 59.11  ? 140 THR A CA  1 
ATOM   684  C C   . THR A 1 140 ? 96.144  109.112 89.314  1.00 57.22  ? 140 THR A C   1 
ATOM   685  O O   . THR A 1 140 ? 97.297  109.506 89.355  1.00 76.83  ? 140 THR A O   1 
ATOM   686  C CB  . THR A 1 140 ? 94.374  110.715 90.090  1.00 68.84  ? 140 THR A CB  1 
ATOM   687  O OG1 . THR A 1 140 ? 93.339  111.606 89.687  1.00 72.93  ? 140 THR A OG1 1 
ATOM   688  C CG2 . THR A 1 140 ? 95.323  111.501 90.956  1.00 75.49  ? 140 THR A CG2 1 
ATOM   689  N N   . LEU A 1 141 ? 95.836  107.841 89.613  1.00 62.23  ? 141 LEU A N   1 
ATOM   690  C CA  . LEU A 1 141 ? 96.862  106.875 89.986  1.00 64.33  ? 141 LEU A CA  1 
ATOM   691  C C   . LEU A 1 141 ? 97.746  106.490 88.793  1.00 73.30  ? 141 LEU A C   1 
ATOM   692  O O   . LEU A 1 141 ? 98.931  106.250 88.991  1.00 80.10  ? 141 LEU A O   1 
ATOM   693  C CB  . LEU A 1 141 ? 96.219  105.618 90.580  1.00 72.15  ? 141 LEU A CB  1 
ATOM   694  C CG  . LEU A 1 141 ? 95.568  105.732 91.947  1.00 75.66  ? 141 LEU A CG  1 
ATOM   695  C CD1 . LEU A 1 141 ? 94.974  104.381 92.337  1.00 85.86  ? 141 LEU A CD1 1 
ATOM   696  C CD2 . LEU A 1 141 ? 96.560  106.204 92.985  1.00 79.11  ? 141 LEU A CD2 1 
ATOM   697  N N   . LEU A 1 142 ? 97.211  106.419 87.560  1.00 76.82  ? 142 LEU A N   1 
ATOM   698  C CA  . LEU A 1 142 ? 98.047  106.209 86.387  1.00 70.67  ? 142 LEU A CA  1 
ATOM   699  C C   . LEU A 1 142 ? 98.998  107.398 86.198  1.00 79.37  ? 142 LEU A C   1 
ATOM   700  O O   . LEU A 1 142 ? 100.201 107.201 86.089  1.00 78.87  ? 142 LEU A O   1 
ATOM   701  C CB  . LEU A 1 142 ? 97.184  106.043 85.137  1.00 76.88  ? 142 LEU A CB  1 
ATOM   702  C CG  . LEU A 1 142 ? 96.371  104.769 85.032  1.00 76.91  ? 142 LEU A CG  1 
ATOM   703  C CD1 . LEU A 1 142 ? 95.529  104.800 83.762  1.00 84.32  ? 142 LEU A CD1 1 
ATOM   704  C CD2 . LEU A 1 142 ? 97.287  103.584 85.044  1.00 79.73  ? 142 LEU A CD2 1 
ATOM   705  N N   . ALA A 1 143 ? 98.463  108.626 86.147  1.00 72.65  ? 143 ALA A N   1 
ATOM   706  C CA  . ALA A 1 143 ? 99.231  109.827 85.862  1.00 78.92  ? 143 ALA A CA  1 
ATOM   707  C C   . ALA A 1 143 ? 100.304 110.094 86.919  1.00 67.16  ? 143 ALA A C   1 
ATOM   708  O O   . ALA A 1 143 ? 101.322 110.723 86.639  1.00 82.02  ? 143 ALA A O   1 
ATOM   709  C CB  . ALA A 1 143 ? 98.289  111.001 85.729  1.00 92.11  ? 143 ALA A CB  1 
ATOM   710  N N   . ASN A 1 144 ? 100.093 109.608 88.136  1.00 66.53  ? 144 ASN A N   1 
ATOM   711  C CA  . ASN A 1 144 ? 101.021 109.733 89.248  1.00 70.45  ? 144 ASN A CA  1 
ATOM   712  C C   . ASN A 1 144 ? 102.369 109.063 88.965  1.00 71.95  ? 144 ASN A C   1 
ATOM   713  O O   . ASN A 1 144 ? 103.388 109.469 89.522  1.00 74.33  ? 144 ASN A O   1 
ATOM   714  C CB  . ASN A 1 144 ? 100.338 109.145 90.480  1.00 86.28  ? 144 ASN A CB  1 
ATOM   715  C CG  . ASN A 1 144 ? 101.114 109.317 91.744  1.00 89.37  ? 144 ASN A CG  1 
ATOM   716  O OD1 . ASN A 1 144 ? 101.580 110.416 92.005  1.00 94.04  ? 144 ASN A OD1 1 
ATOM   717  N ND2 . ASN A 1 144 ? 101.263 108.237 92.494  1.00 96.21  ? 144 ASN A ND2 1 
ATOM   718  N N   . ASN A 1 145 ? 102.400 108.056 88.086  1.00 83.65  ? 145 ASN A N   1 
ATOM   719  C CA  . ASN A 1 145 ? 103.642 107.372 87.730  1.00 78.39  ? 145 ASN A CA  1 
ATOM   720  C C   . ASN A 1 145 ? 104.583 108.268 86.916  1.00 79.11  ? 145 ASN A C   1 
ATOM   721  O O   . ASN A 1 145 ? 105.737 107.921 86.740  1.00 84.29  ? 145 ASN A O   1 
ATOM   722  C CB  . ASN A 1 145 ? 103.348 106.065 86.993  1.00 72.51  ? 145 ASN A CB  1 
ATOM   723  C CG  . ASN A 1 145 ? 102.658 105.109 87.929  1.00 85.35  ? 145 ASN A CG  1 
ATOM   724  O OD1 . ASN A 1 145 ? 103.267 104.611 88.872  1.00 110.21 ? 145 ASN A OD1 1 
ATOM   725  N ND2 . ASN A 1 145 ? 101.375 104.898 87.730  1.00 101.26 ? 145 ASN A ND2 1 
ATOM   726  N N   . GLY A 1 146 ? 104.122 109.423 86.433  1.00 77.05  ? 146 GLY A N   1 
ATOM   727  C CA  . GLY A 1 146 ? 105.020 110.409 85.861  1.00 78.59  ? 146 GLY A CA  1 
ATOM   728  C C   . GLY A 1 146 ? 106.035 110.930 86.879  1.00 71.59  ? 146 GLY A C   1 
ATOM   729  O O   . GLY A 1 146 ? 107.123 111.340 86.502  1.00 90.01  ? 146 GLY A O   1 
ATOM   730  N N   . PHE A 1 147 ? 105.643 110.993 88.158  1.00 66.45  ? 147 PHE A N   1 
ATOM   731  C CA  . PHE A 1 147 ? 106.495 111.460 89.233  1.00 69.39  ? 147 PHE A CA  1 
ATOM   732  C C   . PHE A 1 147 ? 107.391 110.330 89.743  1.00 74.80  ? 147 PHE A C   1 
ATOM   733  O O   . PHE A 1 147 ? 108.562 110.554 90.014  1.00 99.61  ? 147 PHE A O   1 
ATOM   734  C CB  . PHE A 1 147 ? 105.644 112.027 90.370  1.00 74.40  ? 147 PHE A CB  1 
ATOM   735  C CG  . PHE A 1 147 ? 104.791 113.227 90.035  1.00 92.77  ? 147 PHE A CG  1 
ATOM   736  C CD1 . PHE A 1 147 ? 105.349 114.354 89.452  1.00 89.35  ? 147 PHE A CD1 1 
ATOM   737  C CD2 . PHE A 1 147 ? 103.434 113.241 90.340  1.00 103.64 ? 147 PHE A CD2 1 
ATOM   738  C CE1 . PHE A 1 147 ? 104.572 115.466 89.177  1.00 94.02  ? 147 PHE A CE1 1 
ATOM   739  C CE2 . PHE A 1 147 ? 102.652 114.340 90.030  1.00 99.62  ? 147 PHE A CE2 1 
ATOM   740  C CZ  . PHE A 1 147 ? 103.225 115.447 89.453  1.00 104.57 ? 147 PHE A CZ  1 
ATOM   741  N N   . ALA A 1 148 ? 106.884 109.100 89.838  1.00 77.82  ? 148 ALA A N   1 
ATOM   742  C CA  . ALA A 1 148 ? 107.690 107.952 90.238  1.00 65.39  ? 148 ALA A CA  1 
ATOM   743  C C   . ALA A 1 148 ? 108.849 107.729 89.273  1.00 60.18  ? 148 ALA A C   1 
ATOM   744  O O   . ALA A 1 148 ? 109.978 107.551 89.707  1.00 71.81  ? 148 ALA A O   1 
ATOM   745  C CB  . ALA A 1 148 ? 106.819 106.714 90.279  1.00 84.30  ? 148 ALA A CB  1 
ATOM   746  N N   . ILE A 1 149 ? 108.575 107.687 87.963  1.00 65.99  ? 149 ILE A N   1 
ATOM   747  C CA  . ILE A 1 149 ? 109.567 107.331 86.962  1.00 63.31  ? 149 ILE A CA  1 
ATOM   748  C C   . ILE A 1 149 ? 110.573 108.473 86.779  1.00 73.29  ? 149 ILE A C   1 
ATOM   749  O O   . ILE A 1 149 ? 111.765 108.219 86.650  1.00 86.68  ? 149 ILE A O   1 
ATOM   750  C CB  . ILE A 1 149 ? 108.870 106.911 85.653  1.00 64.44  ? 149 ILE A CB  1 
ATOM   751  C CG1 . ILE A 1 149 ? 108.092 105.608 85.872  1.00 68.00  ? 149 ILE A CG1 1 
ATOM   752  C CG2 . ILE A 1 149 ? 109.865 106.805 84.497  1.00 72.65  ? 149 ILE A CG2 1 
ATOM   753  C CD1 . ILE A 1 149 ? 107.263 105.149 84.679  1.00 70.99  ? 149 ILE A CD1 1 
ATOM   754  N N   . SER A 1 150 ? 110.120 109.735 86.799  1.00 73.21  ? 150 SER A N   1 
ATOM   755  C CA  . SER A 1 150 ? 110.996 110.882 86.668  1.00 70.33  ? 150 SER A CA  1 
ATOM   756  C C   . SER A 1 150 ? 111.915 111.008 87.878  1.00 72.12  ? 150 SER A C   1 
ATOM   757  O O   . SER A 1 150 ? 113.088 111.336 87.727  1.00 91.62  ? 150 SER A O   1 
ATOM   758  C CB  . SER A 1 150 ? 110.207 112.141 86.473  1.00 89.73  ? 150 SER A CB  1 
ATOM   759  O OG  . SER A 1 150 ? 109.422 112.054 85.290  1.00 120.02 ? 150 SER A OG  1 
ATOM   760  N N   . ALA A 1 151 ? 111.392 110.782 89.082  1.00 70.68  ? 151 ALA A N   1 
ATOM   761  C CA  . ALA A 1 151 ? 112.185 110.872 90.297  1.00 66.70  ? 151 ALA A CA  1 
ATOM   762  C C   . ALA A 1 151 ? 113.184 109.722 90.378  1.00 73.67  ? 151 ALA A C   1 
ATOM   763  O O   . ALA A 1 151 ? 114.336 109.948 90.727  1.00 96.47  ? 151 ALA A O   1 
ATOM   764  C CB  . ALA A 1 151 ? 111.276 110.905 91.504  1.00 68.53  ? 151 ALA A CB  1 
ATOM   765  N N   . ALA A 1 152 ? 112.773 108.497 90.030  1.00 73.22  ? 152 ALA A N   1 
ATOM   766  C CA  . ALA A 1 152 ? 113.672 107.356 89.961  1.00 64.63  ? 152 ALA A CA  1 
ATOM   767  C C   . ALA A 1 152 ? 114.848 107.624 89.020  1.00 70.66  ? 152 ALA A C   1 
ATOM   768  O O   . ALA A 1 152 ? 115.982 107.325 89.379  1.00 93.86  ? 152 ALA A O   1 
ATOM   769  C CB  . ALA A 1 152 ? 112.911 106.121 89.548  1.00 70.03  ? 152 ALA A CB  1 
ATOM   770  N N   . LEU A 1 153 ? 114.610 108.231 87.851  1.00 76.29  ? 153 LEU A N   1 
ATOM   771  C CA  . LEU A 1 153 ? 115.671 108.523 86.896  1.00 80.88  ? 153 LEU A CA  1 
ATOM   772  C C   . LEU A 1 153 ? 116.554 109.695 87.342  1.00 69.92  ? 153 LEU A C   1 
ATOM   773  O O   . LEU A 1 153 ? 117.753 109.669 87.093  1.00 86.71  ? 153 LEU A O   1 
ATOM   774  C CB  . LEU A 1 153 ? 115.064 108.781 85.512  1.00 87.42  ? 153 LEU A CB  1 
ATOM   775  C CG  . LEU A 1 153 ? 114.471 107.553 84.823  1.00 97.05  ? 153 LEU A CG  1 
ATOM   776  C CD1 . LEU A 1 153 ? 113.891 107.932 83.473  1.00 104.02 ? 153 LEU A CD1 1 
ATOM   777  C CD2 . LEU A 1 153 ? 115.505 106.448 84.664  1.00 116.65 ? 153 LEU A CD2 1 
ATOM   778  N N   . LEU A 1 154 ? 115.999 110.710 88.007  1.00 69.23  ? 154 LEU A N   1 
ATOM   779  C CA  . LEU A 1 154 ? 116.806 111.808 88.544  1.00 74.62  ? 154 LEU A CA  1 
ATOM   780  C C   . LEU A 1 154 ? 117.747 111.307 89.639  1.00 73.62  ? 154 LEU A C   1 
ATOM   781  O O   . LEU A 1 154 ? 118.898 111.709 89.694  1.00 85.80  ? 154 LEU A O   1 
ATOM   782  C CB  . LEU A 1 154 ? 115.900 112.899 89.132  1.00 69.68  ? 154 LEU A CB  1 
ATOM   783  C CG  . LEU A 1 154 ? 115.277 113.866 88.148  1.00 67.55  ? 154 LEU A CG  1 
ATOM   784  C CD1 . LEU A 1 154 ? 114.225 114.709 88.849  1.00 69.30  ? 154 LEU A CD1 1 
ATOM   785  C CD2 . LEU A 1 154 ? 116.352 114.727 87.537  1.00 69.88  ? 154 LEU A CD2 1 
ATOM   786  N N   . MET A 1 155 ? 117.259 110.433 90.528  1.00 63.25  ? 155 MET A N   1 
ATOM   787  C CA  . MET A 1 155 ? 118.044 109.983 91.657  1.00 59.38  ? 155 MET A CA  1 
ATOM   788  C C   . MET A 1 155 ? 119.103 108.965 91.221  1.00 60.14  ? 155 MET A C   1 
ATOM   789  O O   . MET A 1 155 ? 120.243 109.042 91.664  1.00 68.27  ? 155 MET A O   1 
ATOM   790  C CB  . MET A 1 155 ? 117.126 109.391 92.720  1.00 62.33  ? 155 MET A CB  1 
ATOM   791  C CG  . MET A 1 155 ? 116.273 110.448 93.378  1.00 64.80  ? 155 MET A CG  1 
ATOM   792  S SD  . MET A 1 155 ? 115.423 109.894 94.888  1.00 77.52  ? 155 MET A SD  1 
ATOM   793  C CE  . MET A 1 155 ? 114.290 108.668 94.227  1.00 74.50  ? 155 MET A CE  1 
ATOM   794  N N   . ALA A 1 156 ? 118.754 108.049 90.318  1.00 62.14  ? 156 ALA A N   1 
ATOM   795  C CA  . ALA A 1 156 ? 119.682 107.047 89.822  1.00 69.16  ? 156 ALA A CA  1 
ATOM   796  C C   . ALA A 1 156 ? 120.835 107.679 89.040  1.00 82.78  ? 156 ALA A C   1 
ATOM   797  O O   . ALA A 1 156 ? 121.995 107.300 89.241  1.00 100.20 ? 156 ALA A O   1 
ATOM   798  C CB  . ALA A 1 156 ? 118.944 106.018 88.996  1.00 69.97  ? 156 ALA A CB  1 
ATOM   799  N N   . CYS A 1 157 ? 120.544 108.633 88.144  1.00 75.65  ? 157 CYS A N   1 
ATOM   800  C CA  . CYS A 1 157 ? 121.568 109.203 87.280  1.00 80.92  ? 157 CYS A CA  1 
ATOM   801  C C   . CYS A 1 157 ? 122.307 110.386 87.908  1.00 78.81  ? 157 CYS A C   1 
ATOM   802  O O   . CYS A 1 157 ? 123.136 111.010 87.240  1.00 95.38  ? 157 CYS A O   1 
ATOM   803  C CB  . CYS A 1 157 ? 120.959 109.586 85.942  1.00 92.52  ? 157 CYS A CB  1 
ATOM   804  S SG  . CYS A 1 157 ? 120.348 108.124 85.061  1.00 144.71 ? 157 CYS A SG  1 
ATOM   805  N N   . SER A 1 158 ? 122.064 110.664 89.196  1.00 78.75  ? 158 SER A N   1 
ATOM   806  C CA  . SER A 1 158 ? 122.701 111.773 89.892  1.00 80.24  ? 158 SER A CA  1 
ATOM   807  C C   . SER A 1 158 ? 124.217 111.588 89.954  1.00 77.81  ? 158 SER A C   1 
ATOM   808  O O   . SER A 1 158 ? 124.965 112.539 89.774  1.00 85.44  ? 158 SER A O   1 
ATOM   809  C CB  . SER A 1 158 ? 122.108 111.960 91.278  1.00 82.44  ? 158 SER A CB  1 
ATOM   810  O OG  . SER A 1 158 ? 122.296 110.792 92.072  1.00 93.54  ? 158 SER A OG  1 
ATOM   811  N N   . LEU A 1 159 ? 124.671 110.358 90.217  1.00 82.69  ? 159 LEU A N   1 
ATOM   812  C CA  . LEU A 1 159 ? 126.087 110.061 90.378  1.00 75.44  ? 159 LEU A CA  1 
ATOM   813  C C   . LEU A 1 159 ? 126.849 110.184 89.054  1.00 66.86  ? 159 LEU A C   1 
ATOM   814  O O   . LEU A 1 159 ? 128.005 110.594 89.055  1.00 70.56  ? 159 LEU A O   1 
ATOM   815  C CB  . LEU A 1 159 ? 126.216 108.663 90.996  1.00 78.37  ? 159 LEU A CB  1 
ATOM   816  C CG  . LEU A 1 159 ? 127.632 108.127 91.198  1.00 75.81  ? 159 LEU A CG  1 
ATOM   817  C CD1 . LEU A 1 159 ? 128.407 108.999 92.162  1.00 78.10  ? 159 LEU A CD1 1 
ATOM   818  C CD2 . LEU A 1 159 ? 127.596 106.693 91.703  1.00 80.48  ? 159 LEU A CD2 1 
ATOM   819  N N   . GLN A 1 160 ? 126.220 109.832 87.926  1.00 79.06  ? 160 GLN A N   1 
ATOM   820  C CA  . GLN A 1 160 ? 126.856 109.936 86.616  1.00 87.61  ? 160 GLN A CA  1 
ATOM   821  C C   . GLN A 1 160 ? 126.915 111.390 86.150  1.00 86.37  ? 160 GLN A C   1 
ATOM   822  O O   . GLN A 1 160 ? 127.896 111.788 85.513  1.00 95.54  ? 160 GLN A O   1 
ATOM   823  C CB  . GLN A 1 160 ? 126.149 109.045 85.591  1.00 97.79  ? 160 GLN A CB  1 
ATOM   824  C CG  . GLN A 1 160 ? 126.540 107.573 85.694  1.00 134.64 ? 160 GLN A CG  1 
ATOM   825  C CD  . GLN A 1 160 ? 126.127 106.907 86.994  1.00 179.49 ? 160 GLN A CD  1 
ATOM   826  O OE1 . GLN A 1 160 ? 125.056 107.169 87.548  1.00 172.08 ? 160 GLN A OE1 1 
ATOM   827  N NE2 . GLN A 1 160 ? 126.982 106.027 87.501  1.00 194.43 ? 160 GLN A NE2 1 
ATOM   828  N N   . ALA A 1 161 ? 125.865 112.170 86.451  1.00 91.05  ? 161 ALA A N   1 
ATOM   829  C CA  . ALA A 1 161 ? 125.840 113.601 86.180  1.00 93.74  ? 161 ALA A CA  1 
ATOM   830  C C   . ALA A 1 161 ? 126.899 114.335 87.002  1.00 85.64  ? 161 ALA A C   1 
ATOM   831  O O   . ALA A 1 161 ? 127.438 115.349 86.556  1.00 96.84  ? 161 ALA A O   1 
ATOM   832  C CB  . ALA A 1 161 ? 124.453 114.136 86.459  1.00 90.03  ? 161 ALA A CB  1 
ATOM   833  N N   . GLY A 1 162 ? 127.158 113.842 88.219  1.00 100.18 ? 162 GLY A N   1 
ATOM   834  C CA  . GLY A 1 162 ? 128.125 114.429 89.134  1.00 98.62  ? 162 GLY A CA  1 
ATOM   835  C C   . GLY A 1 162 ? 127.569 115.650 89.866  1.00 95.07  ? 162 GLY A C   1 
ATOM   836  O O   . GLY A 1 162 ? 128.327 116.549 90.256  1.00 116.02 ? 162 GLY A O   1 
ATOM   837  N N   . ALA A 1 163 ? 126.244 115.665 90.059  1.00 82.27  ? 163 ALA A N   1 
ATOM   838  C CA  . ALA A 1 163 ? 125.538 116.772 90.694  1.00 82.82  ? 163 ALA A CA  1 
ATOM   839  C C   . ALA A 1 163 ? 124.658 116.250 91.819  1.00 73.62  ? 163 ALA A C   1 
ATOM   840  O O   . ALA A 1 163 ? 123.774 115.446 91.562  1.00 66.00  ? 163 ALA A O   1 
ATOM   841  C CB  . ALA A 1 163 ? 124.689 117.500 89.683  1.00 83.95  ? 163 ALA A CB  1 
ATOM   842  N N   . PHE A 1 164 ? 124.870 116.748 93.050  1.00 77.44  ? 164 PHE A N   1 
ATOM   843  C CA  . PHE A 1 164 ? 124.094 116.298 94.198  1.00 76.26  ? 164 PHE A CA  1 
ATOM   844  C C   . PHE A 1 164 ? 122.692 116.917 94.213  1.00 83.37  ? 164 PHE A C   1 
ATOM   845  O O   . PHE A 1 164 ? 121.798 116.374 94.850  1.00 84.64  ? 164 PHE A O   1 
ATOM   846  C CB  . PHE A 1 164 ? 124.869 116.527 95.497  1.00 83.07  ? 164 PHE A CB  1 
ATOM   847  C CG  . PHE A 1 164 ? 125.108 117.958 95.910  1.00 92.30  ? 164 PHE A CG  1 
ATOM   848  C CD1 . PHE A 1 164 ? 124.149 118.683 96.602  1.00 89.17  ? 164 PHE A CD1 1 
ATOM   849  C CD2 . PHE A 1 164 ? 126.315 118.572 95.624  1.00 104.99 ? 164 PHE A CD2 1 
ATOM   850  C CE1 . PHE A 1 164 ? 124.373 120.004 96.942  1.00 96.93  ? 164 PHE A CE1 1 
ATOM   851  C CE2 . PHE A 1 164 ? 126.541 119.889 95.986  1.00 114.05 ? 164 PHE A CE2 1 
ATOM   852  C CZ  . PHE A 1 164 ? 125.578 120.601 96.650  1.00 115.15 ? 164 PHE A CZ  1 
ATOM   853  N N   . GLU A 1 165 ? 122.474 118.026 93.485  1.00 84.36  ? 165 GLU A N   1 
ATOM   854  C CA  . GLU A 1 165 ? 121.171 118.664 93.450  1.00 75.31  ? 165 GLU A CA  1 
ATOM   855  C C   . GLU A 1 165 ? 120.121 117.738 92.826  1.00 75.39  ? 165 GLU A C   1 
ATOM   856  O O   . GLU A 1 165 ? 118.954 117.817 93.196  1.00 96.46  ? 165 GLU A O   1 
ATOM   857  C CB  . GLU A 1 165 ? 121.237 119.987 92.696  1.00 78.65  ? 165 GLU A CB  1 
ATOM   858  C CG  . GLU A 1 165 ? 122.083 121.019 93.411  1.00 89.05  ? 165 GLU A CG  1 
ATOM   859  C CD  . GLU A 1 165 ? 123.486 121.206 92.868  1.00 97.87  ? 165 GLU A CD  1 
ATOM   860  O OE1 . GLU A 1 165 ? 124.109 120.204 92.507  1.00 80.98  ? 165 GLU A OE1 1 
ATOM   861  O OE2 . GLU A 1 165 ? 123.951 122.371 92.811  1.00 136.37 ? 165 GLU A OE2 1 
ATOM   862  N N   . MET A 1 166 ? 120.516 116.869 91.891  1.00 61.00  ? 166 MET A N   1 
ATOM   863  C CA  . MET A 1 166 ? 119.588 115.952 91.256  1.00 56.52  ? 166 MET A CA  1 
ATOM   864  C C   . MET A 1 166 ? 118.991 114.979 92.270  1.00 55.13  ? 166 MET A C   1 
ATOM   865  O O   . MET A 1 166 ? 117.870 114.511 92.088  1.00 75.77  ? 166 MET A O   1 
ATOM   866  C CB  . MET A 1 166 ? 120.284 115.165 90.137  1.00 58.95  ? 166 MET A CB  1 
ATOM   867  C CG  . MET A 1 166 ? 120.421 115.932 88.873  1.00 71.32  ? 166 MET A CG  1 
ATOM   868  S SD  . MET A 1 166 ? 121.496 115.119 87.680  1.00 75.96  ? 166 MET A SD  1 
ATOM   869  C CE  . MET A 1 166 ? 120.388 113.837 87.129  1.00 84.32  ? 166 MET A CE  1 
ATOM   870  N N   . LEU A 1 167 ? 119.746 114.609 93.306  1.00 58.76  ? 167 LEU A N   1 
ATOM   871  C CA  . LEU A 1 167 ? 119.287 113.647 94.294  1.00 59.31  ? 167 LEU A CA  1 
ATOM   872  C C   . LEU A 1 167 ? 118.354 114.320 95.299  1.00 58.60  ? 167 LEU A C   1 
ATOM   873  O O   . LEU A 1 167 ? 117.413 113.682 95.770  1.00 64.55  ? 167 LEU A O   1 
ATOM   874  C CB  . LEU A 1 167 ? 120.533 112.998 94.928  1.00 64.19  ? 167 LEU A CB  1 
ATOM   875  C CG  . LEU A 1 167 ? 120.341 111.842 95.901  1.00 67.15  ? 167 LEU A CG  1 
ATOM   876  C CD1 . LEU A 1 167 ? 119.408 110.780 95.362  1.00 72.13  ? 167 LEU A CD1 1 
ATOM   877  C CD2 . LEU A 1 167 ? 121.688 111.217 96.213  1.00 71.77  ? 167 LEU A CD2 1 
ATOM   878  N N   . ILE A 1 168 ? 118.558 115.617 95.591  1.00 72.40  ? 168 ILE A N   1 
ATOM   879  C CA  . ILE A 1 168 ? 117.645 116.393 96.438  1.00 71.62  ? 168 ILE A CA  1 
ATOM   880  C C   . ILE A 1 168 ? 116.341 116.698 95.689  1.00 69.62  ? 168 ILE A C   1 
ATOM   881  O O   . ILE A 1 168 ? 115.263 116.554 96.261  1.00 74.62  ? 168 ILE A O   1 
ATOM   882  C CB  . ILE A 1 168 ? 118.339 117.663 96.974  1.00 64.88  ? 168 ILE A CB  1 
ATOM   883  C CG1 . ILE A 1 168 ? 119.576 117.312 97.809  1.00 83.05  ? 168 ILE A CG1 1 
ATOM   884  C CG2 . ILE A 1 168 ? 117.369 118.497 97.780  1.00 63.64  ? 168 ILE A CG2 1 
ATOM   885  C CD1 . ILE A 1 168 ? 120.452 118.497 98.153  1.00 90.95  ? 168 ILE A CD1 1 
ATOM   886  N N   . VAL A 1 169 ? 116.424 117.081 94.406  1.00 68.25  ? 169 VAL A N   1 
ATOM   887  C CA  . VAL A 1 169 ? 115.257 117.332 93.561  1.00 60.40  ? 169 VAL A CA  1 
ATOM   888  C C   . VAL A 1 169 ? 114.495 116.030 93.260  1.00 54.84  ? 169 VAL A C   1 
ATOM   889  O O   . VAL A 1 169 ? 113.276 116.042 93.154  1.00 68.97  ? 169 VAL A O   1 
ATOM   890  C CB  . VAL A 1 169 ? 115.656 118.058 92.261  1.00 56.19  ? 169 VAL A CB  1 
ATOM   891  C CG1 . VAL A 1 169 ? 114.523 118.127 91.259  1.00 59.82  ? 169 VAL A CG1 1 
ATOM   892  C CG2 . VAL A 1 169 ? 116.184 119.444 92.540  1.00 64.81  ? 169 VAL A CG2 1 
ATOM   893  N N   . GLY A 1 170 ? 115.188 114.901 93.150  1.00 57.74  ? 170 GLY A N   1 
ATOM   894  C CA  . GLY A 1 170 ? 114.539 113.614 92.961  1.00 57.18  ? 170 GLY A CA  1 
ATOM   895  C C   . GLY A 1 170 ? 113.743 113.173 94.190  1.00 54.86  ? 170 GLY A C   1 
ATOM   896  O O   . GLY A 1 170 ? 112.626 112.702 94.057  1.00 57.08  ? 170 GLY A O   1 
ATOM   897  N N   . ARG A 1 171 ? 114.295 113.345 95.397  1.00 53.73  ? 171 ARG A N   1 
ATOM   898  C CA  . ARG A 1 171 ? 113.582 113.038 96.626  1.00 48.73  ? 171 ARG A CA  1 
ATOM   899  C C   . ARG A 1 171 ? 112.320 113.875 96.751  1.00 50.41  ? 171 ARG A C   1 
ATOM   900  O O   . ARG A 1 171 ? 111.316 113.392 97.274  1.00 57.77  ? 171 ARG A O   1 
ATOM   901  C CB  . ARG A 1 171 ? 114.470 113.261 97.858  1.00 49.65  ? 171 ARG A CB  1 
ATOM   902  C CG  . ARG A 1 171 ? 115.498 112.174 98.104  1.00 48.20  ? 171 ARG A CG  1 
ATOM   903  C CD  . ARG A 1 171 ? 114.819 110.964 98.657  1.00 50.03  ? 171 ARG A CD  1 
ATOM   904  N NE  . ARG A 1 171 ? 114.379 111.103 100.024 1.00 45.68  ? 171 ARG A NE  1 
ATOM   905  C CZ  . ARG A 1 171 ? 113.788 110.121 100.715 1.00 57.92  ? 171 ARG A CZ  1 
ATOM   906  N NH1 . ARG A 1 171 ? 113.402 110.315 101.966 1.00 62.03  ? 171 ARG A NH1 1 
ATOM   907  N NH2 . ARG A 1 171 ? 113.546 108.956 100.141 1.00 56.02  ? 171 ARG A NH2 1 
ATOM   908  N N   . PHE A 1 172 ? 112.366 115.137 96.301  1.00 55.39  ? 172 PHE A N   1 
ATOM   909  C CA  . PHE A 1 172 ? 111.204 116.019 96.336  1.00 50.36  ? 172 PHE A CA  1 
ATOM   910  C C   . PHE A 1 172 ? 110.070 115.470 95.479  1.00 54.54  ? 172 PHE A C   1 
ATOM   911  O O   . PHE A 1 172 ? 108.956 115.303 95.987  1.00 60.04  ? 172 PHE A O   1 
ATOM   912  C CB  . PHE A 1 172 ? 111.581 117.433 95.906  1.00 52.79  ? 172 PHE A CB  1 
ATOM   913  C CG  . PHE A 1 172 ? 110.387 118.349 95.812  1.00 61.12  ? 172 PHE A CG  1 
ATOM   914  C CD1 . PHE A 1 172 ? 109.707 118.735 96.964  1.00 60.27  ? 172 PHE A CD1 1 
ATOM   915  C CD2 . PHE A 1 172 ? 109.942 118.816 94.585  1.00 63.93  ? 172 PHE A CD2 1 
ATOM   916  C CE1 . PHE A 1 172 ? 108.622 119.583 96.892  1.00 60.23  ? 172 PHE A CE1 1 
ATOM   917  C CE2 . PHE A 1 172 ? 108.833 119.640 94.522  1.00 75.12  ? 172 PHE A CE2 1 
ATOM   918  C CZ  . PHE A 1 172 ? 108.167 120.002 95.670  1.00 70.20  ? 172 PHE A CZ  1 
ATOM   919  N N   . ILE A 1 173 ? 110.335 115.173 94.189  1.00 60.13  ? 173 ILE A N   1 
ATOM   920  C CA  . ILE A 1 173 ? 109.310 114.722 93.251  1.00 53.37  ? 173 ILE A CA  1 
ATOM   921  C C   . ILE A 1 173 ? 108.732 113.376 93.690  1.00 50.62  ? 173 ILE A C   1 
ATOM   922  O O   . ILE A 1 173 ? 107.527 113.166 93.559  1.00 65.26  ? 173 ILE A O   1 
ATOM   923  C CB  . ILE A 1 173 ? 109.874 114.711 91.818  1.00 49.64  ? 173 ILE A CB  1 
ATOM   924  C CG1 . ILE A 1 173 ? 110.206 116.132 91.368  1.00 57.35  ? 173 ILE A CG1 1 
ATOM   925  C CG2 . ILE A 1 173 ? 108.930 114.064 90.848  1.00 54.37  ? 173 ILE A CG2 1 
ATOM   926  C CD1 . ILE A 1 173 ? 111.000 116.208 90.094  1.00 62.30  ? 173 ILE A CD1 1 
ATOM   927  N N   . MET A 1 174 ? 109.571 112.482 94.211  1.00 52.34  ? 174 MET A N   1 
ATOM   928  C CA  . MET A 1 174 ? 109.134 111.219 94.783  1.00 59.14  ? 174 MET A CA  1 
ATOM   929  C C   . MET A 1 174 ? 108.233 111.460 96.006  1.00 55.61  ? 174 MET A C   1 
ATOM   930  O O   . MET A 1 174 ? 107.389 110.628 96.341  1.00 59.69  ? 174 MET A O   1 
ATOM   931  C CB  . MET A 1 174 ? 110.374 110.417 95.201  1.00 72.51  ? 174 MET A CB  1 
ATOM   932  C CG  . MET A 1 174 ? 110.120 108.963 95.529  1.00 81.05  ? 174 MET A CG  1 
ATOM   933  S SD  . MET A 1 174 ? 109.547 107.983 94.126  1.00 90.96  ? 174 MET A SD  1 
ATOM   934  C CE  . MET A 1 174 ? 111.079 107.830 93.202  1.00 105.85 ? 174 MET A CE  1 
ATOM   935  N N   . GLY A 1 175 ? 108.420 112.591 96.687  1.00 52.49  ? 175 GLY A N   1 
ATOM   936  C CA  . GLY A 1 175 ? 107.528 113.018 97.753  1.00 51.49  ? 175 GLY A CA  1 
ATOM   937  C C   . GLY A 1 175 ? 106.147 113.380 97.226  1.00 50.06  ? 175 GLY A C   1 
ATOM   938  O O   . GLY A 1 175 ? 105.158 112.949 97.801  1.00 61.95  ? 175 GLY A O   1 
ATOM   939  N N   . ILE A 1 176 ? 106.083 114.170 96.146  1.00 51.53  ? 176 ILE A N   1 
ATOM   940  C CA  . ILE A 1 176 ? 104.816 114.542 95.530  1.00 55.00  ? 176 ILE A CA  1 
ATOM   941  C C   . ILE A 1 176 ? 104.027 113.280 95.196  1.00 56.50  ? 176 ILE A C   1 
ATOM   942  O O   . ILE A 1 176 ? 102.849 113.193 95.527  1.00 64.57  ? 176 ILE A O   1 
ATOM   943  C CB  . ILE A 1 176 ? 105.010 115.425 94.273  1.00 56.87  ? 176 ILE A CB  1 
ATOM   944  C CG1 . ILE A 1 176 ? 105.785 116.704 94.561  1.00 50.68  ? 176 ILE A CG1 1 
ATOM   945  C CG2 . ILE A 1 176 ? 103.678 115.753 93.618  1.00 56.97  ? 176 ILE A CG2 1 
ATOM   946  C CD1 . ILE A 1 176 ? 105.969 117.531 93.329  1.00 62.86  ? 176 ILE A CD1 1 
ATOM   947  N N   . ASP A 1 177 ? 104.675 112.319 94.537  1.00 62.61  ? 177 ASP A N   1 
ATOM   948  C CA  . ASP A 1 177 ? 104.122 111.004 94.242  1.00 66.61  ? 177 ASP A CA  1 
ATOM   949  C C   . ASP A 1 177 ? 103.495 110.391 95.502  1.00 55.71  ? 177 ASP A C   1 
ATOM   950  O O   . ASP A 1 177 ? 102.327 110.025 95.521  1.00 56.24  ? 177 ASP A O   1 
ATOM   951  C CB  . ASP A 1 177 ? 105.231 110.151 93.617  1.00 75.76  ? 177 ASP A CB  1 
ATOM   952  C CG  . ASP A 1 177 ? 104.931 108.682 93.400  1.00 100.91 ? 177 ASP A CG  1 
ATOM   953  O OD1 . ASP A 1 177 ? 103.774 108.269 93.583  1.00 131.26 ? 177 ASP A OD1 1 
ATOM   954  O OD2 . ASP A 1 177 ? 105.897 107.946 93.091  1.00 126.07 ? 177 ASP A OD2 1 
ATOM   955  N N   . GLY A 1 178 ? 104.271 110.261 96.573  1.00 62.10  ? 178 GLY A N   1 
ATOM   956  C CA  . GLY A 1 178 ? 103.767 109.680 97.803  1.00 63.40  ? 178 GLY A CA  1 
ATOM   957  C C   . GLY A 1 178 ? 102.577 110.427 98.399  1.00 58.70  ? 178 GLY A C   1 
ATOM   958  O O   . GLY A 1 178 ? 101.775 109.821 99.085  1.00 62.25  ? 178 GLY A O   1 
ATOM   959  N N   . GLY A 1 179 ? 102.479 111.749 98.183  1.00 56.84  ? 179 GLY A N   1 
ATOM   960  C CA  . GLY A 1 179 ? 101.364 112.549 98.664  1.00 60.42  ? 179 GLY A CA  1 
ATOM   961  C C   . GLY A 1 179 ? 100.068 112.297 97.889  1.00 63.00  ? 179 GLY A C   1 
ATOM   962  O O   . GLY A 1 179 ? 98.997  112.208 98.487  1.00 79.04  ? 179 GLY A O   1 
ATOM   963  N N   . VAL A 1 180 ? 100.172 112.178 96.558  1.00 58.11  ? 180 VAL A N   1 
ATOM   964  C CA  . VAL A 1 180 ? 99.052  111.850 95.689  1.00 57.58  ? 180 VAL A CA  1 
ATOM   965  C C   . VAL A 1 180 ? 98.631  110.385 95.874  1.00 68.28  ? 180 VAL A C   1 
ATOM   966  O O   . VAL A 1 180 ? 97.445  110.093 95.949  1.00 78.01  ? 180 VAL A O   1 
ATOM   967  C CB  . VAL A 1 180 ? 99.386  112.153 94.217  1.00 60.69  ? 180 VAL A CB  1 
ATOM   968  C CG1 . VAL A 1 180 ? 98.263  111.749 93.276  1.00 72.51  ? 180 VAL A CG1 1 
ATOM   969  C CG2 . VAL A 1 180 ? 99.713  113.606 93.993  1.00 64.61  ? 180 VAL A CG2 1 
ATOM   970  N N   . ALA A 1 181 ? 99.591  109.464 95.982  1.00 75.69  ? 181 ALA A N   1 
ATOM   971  C CA  . ALA A 1 181 ? 99.336  108.049 96.198  1.00 71.50  ? 181 ALA A CA  1 
ATOM   972  C C   . ALA A 1 181 ? 98.482  107.810 97.435  1.00 73.67  ? 181 ALA A C   1 
ATOM   973  O O   . ALA A 1 181 ? 97.517  107.044 97.359  1.00 90.46  ? 181 ALA A O   1 
ATOM   974  C CB  . ALA A 1 181 ? 100.654 107.304 96.315  1.00 86.51  ? 181 ALA A CB  1 
ATOM   975  N N   . LEU A 1 182 ? 98.831  108.434 98.573  1.00 63.14  ? 182 LEU A N   1 
ATOM   976  C CA  . LEU A 1 182 ? 98.184  108.164 99.851  1.00 56.91  ? 182 LEU A CA  1 
ATOM   977  C C   . LEU A 1 182 ? 96.845  108.877 99.993  1.00 57.56  ? 182 LEU A C   1 
ATOM   978  O O   . LEU A 1 182 ? 96.087  108.544 100.906 1.00 73.38  ? 182 LEU A O   1 
ATOM   979  C CB  . LEU A 1 182 ? 99.114  108.575 100.992 1.00 59.98  ? 182 LEU A CB  1 
ATOM   980  C CG  . LEU A 1 182 ? 100.364 107.718 101.195 1.00 68.21  ? 182 LEU A CG  1 
ATOM   981  C CD1 . LEU A 1 182 ? 101.091 108.164 102.464 1.00 73.00  ? 182 LEU A CD1 1 
ATOM   982  C CD2 . LEU A 1 182 ? 100.057 106.212 101.222 1.00 70.94  ? 182 LEU A CD2 1 
ATOM   983  N N   . SER A 1 183 ? 96.564  109.872 99.141  1.00 59.76  ? 183 SER A N   1 
ATOM   984  C CA  . SER A 1 183 ? 95.309  110.611 99.172  1.00 66.35  ? 183 SER A CA  1 
ATOM   985  C C   . SER A 1 183 ? 94.254  109.942 98.299  1.00 67.96  ? 183 SER A C   1 
ATOM   986  O O   . SER A 1 183 ? 93.078  109.946 98.659  1.00 91.39  ? 183 SER A O   1 
ATOM   987  C CB  . SER A 1 183 ? 95.519  112.045 98.754  1.00 85.02  ? 183 SER A CB  1 
ATOM   988  O OG  . SER A 1 183 ? 96.447  112.709 99.613  1.00 103.70 ? 183 SER A OG  1 
ATOM   989  N N   . VAL A 1 184 ? 94.661  109.366 97.154  1.00 68.34  ? 184 VAL A N   1 
ATOM   990  C CA  . VAL A 1 184 ? 93.747  108.820 96.152  1.00 60.24  ? 184 VAL A CA  1 
ATOM   991  C C   . VAL A 1 184 ? 93.578  107.305 96.290  1.00 67.94  ? 184 VAL A C   1 
ATOM   992  O O   . VAL A 1 184 ? 92.534  106.790 95.897  1.00 73.55  ? 184 VAL A O   1 
ATOM   993  C CB  . VAL A 1 184 ? 94.203  109.180 94.724  1.00 62.33  ? 184 VAL A CB  1 
ATOM   994  C CG1 . VAL A 1 184 ? 93.329  108.580 93.647  1.00 65.23  ? 184 VAL A CG1 1 
ATOM   995  C CG2 . VAL A 1 184 ? 94.254  110.682 94.556  1.00 71.27  ? 184 VAL A CG2 1 
ATOM   996  N N   . LEU A 1 185 ? 94.546  106.554 96.843  1.00 75.35  ? 185 LEU A N   1 
ATOM   997  C CA  . LEU A 1 185 ? 94.381  105.103 96.883  1.00 76.93  ? 185 LEU A CA  1 
ATOM   998  C C   . LEU A 1 185 ? 93.275  104.732 97.879  1.00 80.96  ? 185 LEU A C   1 
ATOM   999  O O   . LEU A 1 185 ? 92.446  103.894 97.555  1.00 89.41  ? 185 LEU A O   1 
ATOM   1000 C CB  . LEU A 1 185 ? 95.717  104.418 97.198  1.00 83.58  ? 185 LEU A CB  1 
ATOM   1001 C CG  . LEU A 1 185 ? 95.691  102.891 97.314  1.00 82.82  ? 185 LEU A CG  1 
ATOM   1002 C CD1 . LEU A 1 185 ? 95.485  102.246 95.950  1.00 76.53  ? 185 LEU A CD1 1 
ATOM   1003 C CD2 . LEU A 1 185 ? 96.979  102.385 97.974  1.00 86.24  ? 185 LEU A CD2 1 
ATOM   1004 N N   . PRO A 1 186 ? 93.183  105.297 99.114  1.00 71.96  ? 186 PRO A N   1 
ATOM   1005 C CA  . PRO A 1 186 ? 92.047  105.027 99.990  1.00 73.35  ? 186 PRO A CA  1 
ATOM   1006 C C   . PRO A 1 186 ? 90.676  105.364 99.398  1.00 76.17  ? 186 PRO A C   1 
ATOM   1007 O O   . PRO A 1 186 ? 89.713  104.663 99.684  1.00 76.73  ? 186 PRO A O   1 
ATOM   1008 C CB  . PRO A 1 186 ? 92.337  105.914 101.215 1.00 87.65  ? 186 PRO A CB  1 
ATOM   1009 C CG  . PRO A 1 186 ? 93.841  105.997 101.236 1.00 82.25  ? 186 PRO A CG  1 
ATOM   1010 C CD  . PRO A 1 186 ? 94.193  106.130 99.775  1.00 77.86  ? 186 PRO A CD  1 
ATOM   1011 N N   . MET A 1 187 ? 90.582  106.431 98.583  1.00 68.95  ? 187 MET A N   1 
ATOM   1012 C CA  . MET A 1 187 ? 89.361  106.741 97.855  1.00 69.14  ? 187 MET A CA  1 
ATOM   1013 C C   . MET A 1 187 ? 89.040  105.604 96.880  1.00 66.94  ? 187 MET A C   1 
ATOM   1014 O O   . MET A 1 187 ? 87.980  105.006 96.969  1.00 65.75  ? 187 MET A O   1 
ATOM   1015 C CB  . MET A 1 187 ? 89.469  108.053 97.077  1.00 88.43  ? 187 MET A CB  1 
ATOM   1016 C CG  . MET A 1 187 ? 89.619  109.301 97.941  1.00 107.42 ? 187 MET A CG  1 
ATOM   1017 S SD  . MET A 1 187 ? 89.942  110.775 96.875  1.00 140.91 ? 187 MET A SD  1 
ATOM   1018 C CE  . MET A 1 187 ? 90.330  112.029 98.095  1.00 174.62 ? 187 MET A CE  1 
ATOM   1019 N N   . TYR A 1 188 ? 89.976  105.244 95.998  1.00 77.33  ? 188 TYR A N   1 
ATOM   1020 C CA  . TYR A 1 188 ? 89.742  104.222 94.981  1.00 75.37  ? 188 TYR A CA  1 
ATOM   1021 C C   . TYR A 1 188 ? 89.338  102.886 95.617  1.00 75.75  ? 188 TYR A C   1 
ATOM   1022 O O   . TYR A 1 188 ? 88.353  102.295 95.203  1.00 74.07  ? 188 TYR A O   1 
ATOM   1023 C CB  . TYR A 1 188 ? 90.993  104.077 94.108  1.00 77.17  ? 188 TYR A CB  1 
ATOM   1024 C CG  . TYR A 1 188 ? 90.857  103.139 92.917  1.00 76.92  ? 188 TYR A CG  1 
ATOM   1025 C CD1 . TYR A 1 188 ? 89.849  103.314 91.980  1.00 77.14  ? 188 TYR A CD1 1 
ATOM   1026 C CD2 . TYR A 1 188 ? 91.754  102.094 92.722  1.00 82.88  ? 188 TYR A CD2 1 
ATOM   1027 C CE1 . TYR A 1 188 ? 89.729  102.473 90.884  1.00 85.25  ? 188 TYR A CE1 1 
ATOM   1028 C CE2 . TYR A 1 188 ? 91.637  101.237 91.638  1.00 85.05  ? 188 TYR A CE2 1 
ATOM   1029 C CZ  . TYR A 1 188 ? 90.629  101.434 90.710  1.00 87.82  ? 188 TYR A CZ  1 
ATOM   1030 O OH  . TYR A 1 188 ? 90.515  100.591 89.640  1.00 87.80  ? 188 TYR A OH  1 
ATOM   1031 N N   . LEU A 1 189 ? 90.075  102.405 96.630  1.00 73.95  ? 189 LEU A N   1 
ATOM   1032 C CA  . LEU A 1 189 ? 89.836  101.095 97.220  1.00 71.70  ? 189 LEU A CA  1 
ATOM   1033 C C   . LEU A 1 189 ? 88.505  101.044 97.976  1.00 77.09  ? 189 LEU A C   1 
ATOM   1034 O O   . LEU A 1 189 ? 87.833  100.028 97.920  1.00 79.28  ? 189 LEU A O   1 
ATOM   1035 C CB  . LEU A 1 189 ? 90.987  100.723 98.162  1.00 74.69  ? 189 LEU A CB  1 
ATOM   1036 C CG  . LEU A 1 189 ? 92.340  100.451 97.524  1.00 72.82  ? 189 LEU A CG  1 
ATOM   1037 C CD1 . LEU A 1 189 ? 93.317  99.971  98.590  1.00 80.13  ? 189 LEU A CD1 1 
ATOM   1038 C CD2 . LEU A 1 189 ? 92.224  99.467  96.373  1.00 77.21  ? 189 LEU A CD2 1 
ATOM   1039 N N   . SER A 1 190 ? 88.115  102.110 98.685  1.00 74.70  ? 190 SER A N   1 
ATOM   1040 C CA  . SER A 1 190 ? 86.831  102.116 99.374  1.00 74.75  ? 190 SER A CA  1 
ATOM   1041 C C   . SER A 1 190 ? 85.665  102.249 98.393  1.00 73.22  ? 190 SER A C   1 
ATOM   1042 O O   . SER A 1 190 ? 84.583  101.764 98.686  1.00 95.91  ? 190 SER A O   1 
ATOM   1043 C CB  . SER A 1 190 ? 86.761  103.176 100.457 1.00 88.53  ? 190 SER A CB  1 
ATOM   1044 O OG  . SER A 1 190 ? 86.897  104.485 99.930  1.00 96.46  ? 190 SER A OG  1 
ATOM   1045 N N   . GLU A 1 191 ? 85.864  102.870 97.222  1.00 71.57  ? 191 GLU A N   1 
ATOM   1046 C CA  . GLU A 1 191 ? 84.786  103.089 96.265  1.00 72.20  ? 191 GLU A CA  1 
ATOM   1047 C C   . GLU A 1 191 ? 84.487  101.842 95.428  1.00 62.65  ? 191 GLU A C   1 
ATOM   1048 O O   . GLU A 1 191 ? 83.326  101.636 95.069  1.00 64.47  ? 191 GLU A O   1 
ATOM   1049 C CB  . GLU A 1 191 ? 85.077  104.285 95.353  1.00 80.26  ? 191 GLU A CB  1 
ATOM   1050 C CG  . GLU A 1 191 ? 84.991  105.643 96.036  1.00 97.38  ? 191 GLU A CG  1 
ATOM   1051 C CD  . GLU A 1 191 ? 85.280  106.837 95.134  1.00 111.95 ? 191 GLU A CD  1 
ATOM   1052 O OE1 . GLU A 1 191 ? 85.517  106.623 93.929  1.00 106.86 ? 191 GLU A OE1 1 
ATOM   1053 O OE2 . GLU A 1 191 ? 85.287  107.984 95.643  1.00 138.01 ? 191 GLU A OE2 1 
ATOM   1054 N N   . ILE A 1 192 ? 85.496  101.020 95.097  1.00 69.92  ? 192 ILE A N   1 
ATOM   1055 C CA  . ILE A 1 192 ? 85.297  99.847  94.236  1.00 92.54  ? 192 ILE A CA  1 
ATOM   1056 C C   . ILE A 1 192 ? 84.750  98.654  95.025  1.00 93.56  ? 192 ILE A C   1 
ATOM   1057 O O   . ILE A 1 192 ? 84.146  97.762  94.427  1.00 93.79  ? 192 ILE A O   1 
ATOM   1058 C CB  . ILE A 1 192 ? 86.576  99.414  93.475  1.00 88.44  ? 192 ILE A CB  1 
ATOM   1059 C CG1 . ILE A 1 192 ? 87.698  98.962  94.420  1.00 93.16  ? 192 ILE A CG1 1 
ATOM   1060 C CG2 . ILE A 1 192 ? 87.043  100.491 92.503  1.00 78.64  ? 192 ILE A CG2 1 
ATOM   1061 C CD1 . ILE A 1 192 ? 88.943  98.452  93.721  1.00 86.05  ? 192 ILE A CD1 1 
ATOM   1062 N N   . SER A 1 193 ? 84.945  98.639  96.353  1.00 82.46  ? 193 SER A N   1 
ATOM   1063 C CA  . SER A 1 193 ? 84.782  97.434  97.156  1.00 85.28  ? 193 SER A CA  1 
ATOM   1064 C C   . SER A 1 193 ? 83.337  97.183  97.595  1.00 90.78  ? 193 SER A C   1 
ATOM   1065 O O   . SER A 1 193 ? 82.539  98.114  97.750  1.00 89.27  ? 193 SER A O   1 
ATOM   1066 C CB  . SER A 1 193 ? 85.654  97.499  98.355  1.00 85.42  ? 193 SER A CB  1 
ATOM   1067 O OG  . SER A 1 193 ? 87.014  97.527  97.953  1.00 114.77 ? 193 SER A OG  1 
ATOM   1068 N N   . PRO A 1 194 ? 82.982  95.898  97.861  1.00 73.49  ? 194 PRO A N   1 
ATOM   1069 C CA  . PRO A 1 194 ? 81.711  95.552  98.480  1.00 76.33  ? 194 PRO A CA  1 
ATOM   1070 C C   . PRO A 1 194 ? 81.536  96.265  99.821  1.00 102.43 ? 194 PRO A C   1 
ATOM   1071 O O   . PRO A 1 194 ? 82.509  96.512  100.529 1.00 117.53 ? 194 PRO A O   1 
ATOM   1072 C CB  . PRO A 1 194 ? 81.798  94.038  98.700  1.00 76.60  ? 194 PRO A CB  1 
ATOM   1073 C CG  . PRO A 1 194 ? 82.847  93.553  97.744  1.00 82.05  ? 194 PRO A CG  1 
ATOM   1074 C CD  . PRO A 1 194 ? 83.797  94.713  97.574  1.00 78.18  ? 194 PRO A CD  1 
ATOM   1075 N N   . LYS A 1 195 ? 80.279  96.537  100.180 1.00 116.62 ? 195 LYS A N   1 
ATOM   1076 C CA  . LYS A 1 195 ? 79.930  97.249  101.399 1.00 124.25 ? 195 LYS A CA  1 
ATOM   1077 C C   . LYS A 1 195 ? 80.529  96.569  102.631 1.00 123.74 ? 195 LYS A C   1 
ATOM   1078 O O   . LYS A 1 195 ? 80.900  97.251  103.588 1.00 125.09 ? 195 LYS A O   1 
ATOM   1079 C CB  . LYS A 1 195 ? 78.400  97.333  101.480 1.00 161.46 ? 195 LYS A CB  1 
ATOM   1080 C CG  . LYS A 1 195 ? 77.830  98.118  102.651 1.00 190.36 ? 195 LYS A CG  1 
ATOM   1081 C CD  . LYS A 1 195 ? 76.345  98.369  102.500 1.00 222.07 ? 195 LYS A CD  1 
ATOM   1082 C CE  . LYS A 1 195 ? 75.761  99.230  103.600 1.00 245.92 ? 195 LYS A CE  1 
ATOM   1083 N NZ  . LYS A 1 195 ? 74.335  99.544  103.346 1.00 256.67 ? 195 LYS A NZ  1 
ATOM   1084 N N   . GLU A 1 196 ? 80.606  95.227  102.612 1.00 137.37 ? 196 GLU A N   1 
ATOM   1085 C CA  . GLU A 1 196 ? 80.964  94.429  103.779 1.00 135.02 ? 196 GLU A CA  1 
ATOM   1086 C C   . GLU A 1 196 ? 82.435  94.587  104.167 1.00 118.15 ? 196 GLU A C   1 
ATOM   1087 O O   . GLU A 1 196 ? 82.767  94.387  105.338 1.00 143.00 ? 196 GLU A O   1 
ATOM   1088 C CB  . GLU A 1 196 ? 80.672  92.946  103.527 1.00 153.61 ? 196 GLU A CB  1 
ATOM   1089 C CG  . GLU A 1 196 ? 79.191  92.603  103.416 1.00 193.11 ? 196 GLU A CG  1 
ATOM   1090 C CD  . GLU A 1 196 ? 78.522  92.866  102.074 1.00 215.31 ? 196 GLU A CD  1 
ATOM   1091 O OE1 . GLU A 1 196 ? 79.229  93.256  101.124 1.00 212.36 ? 196 GLU A OE1 1 
ATOM   1092 O OE2 . GLU A 1 196 ? 77.289  92.687  101.985 1.00 236.07 ? 196 GLU A OE2 1 
ATOM   1093 N N   . ILE A 1 197 ? 83.320  94.913  103.209 1.00 100.70 ? 197 ILE A N   1 
ATOM   1094 C CA  . ILE A 1 197 ? 84.759  94.823  103.452 1.00 91.99  ? 197 ILE A CA  1 
ATOM   1095 C C   . ILE A 1 197 ? 85.449  96.200  103.436 1.00 86.83  ? 197 ILE A C   1 
ATOM   1096 O O   . ILE A 1 197 ? 86.662  96.261  103.577 1.00 97.79  ? 197 ILE A O   1 
ATOM   1097 C CB  . ILE A 1 197 ? 85.452  93.825  102.489 1.00 87.00  ? 197 ILE A CB  1 
ATOM   1098 C CG1 . ILE A 1 197 ? 85.656  94.369  101.071 1.00 97.73  ? 197 ILE A CG1 1 
ATOM   1099 C CG2 . ILE A 1 197 ? 84.705  92.505  102.464 1.00 91.16  ? 197 ILE A CG2 1 
ATOM   1100 C CD1 . ILE A 1 197 ? 86.501  93.477  100.195 1.00 108.14 ? 197 ILE A CD1 1 
ATOM   1101 N N   . ARG A 1 198 ? 84.709  97.311  103.325 1.00 77.88  ? 198 ARG A N   1 
ATOM   1102 C CA  . ARG A 1 198 ? 85.314  98.635  103.314 1.00 84.51  ? 198 ARG A CA  1 
ATOM   1103 C C   . ARG A 1 198 ? 86.056  98.931  104.622 1.00 104.86 ? 198 ARG A C   1 
ATOM   1104 O O   . ARG A 1 198 ? 86.889  99.841  104.662 1.00 121.09 ? 198 ARG A O   1 
ATOM   1105 C CB  . ARG A 1 198 ? 84.248  99.716  103.090 1.00 104.41 ? 198 ARG A CB  1 
ATOM   1106 C CG  . ARG A 1 198 ? 83.753  99.818  101.659 1.00 98.50  ? 198 ARG A CG  1 
ATOM   1107 C CD  . ARG A 1 198 ? 82.709  100.912 101.460 1.00 94.29  ? 198 ARG A CD  1 
ATOM   1108 N NE  . ARG A 1 198 ? 82.282  100.928 100.061 1.00 108.65 ? 198 ARG A NE  1 
ATOM   1109 C CZ  . ARG A 1 198 ? 81.027  100.955 99.624  1.00 133.87 ? 198 ARG A CZ  1 
ATOM   1110 N NH1 . ARG A 1 198 ? 80.780  100.812 98.333  1.00 131.61 ? 198 ARG A NH1 1 
ATOM   1111 N NH2 . ARG A 1 198 ? 80.027  101.114 100.476 1.00 158.25 ? 198 ARG A NH2 1 
ATOM   1112 N N   . GLY A 1 199 ? 85.751  98.181  105.695 1.00 118.56 ? 199 GLY A N   1 
ATOM   1113 C CA  . GLY A 1 199 ? 86.419  98.324  106.982 1.00 127.21 ? 199 GLY A CA  1 
ATOM   1114 C C   . GLY A 1 199 ? 87.825  97.718  107.016 1.00 110.60 ? 199 GLY A C   1 
ATOM   1115 O O   . GLY A 1 199 ? 88.672  98.201  107.769 1.00 121.04 ? 199 GLY A O   1 
ATOM   1116 N N   . SER A 1 200 ? 88.058  96.667  106.217 1.00 93.62  ? 200 SER A N   1 
ATOM   1117 C CA  . SER A 1 200 ? 89.328  95.953  106.170 1.00 98.53  ? 200 SER A CA  1 
ATOM   1118 C C   . SER A 1 200 ? 90.412  96.733  105.419 1.00 97.78  ? 200 SER A C   1 
ATOM   1119 O O   . SER A 1 200 ? 91.602  96.549  105.674 1.00 107.75 ? 200 SER A O   1 
ATOM   1120 C CB  . SER A 1 200 ? 89.155  94.588  105.540 1.00 94.17  ? 200 SER A CB  1 
ATOM   1121 O OG  . SER A 1 200 ? 88.281  93.770  106.304 1.00 89.36  ? 200 SER A OG  1 
ATOM   1122 N N   . LEU A 1 201 ? 90.011  97.586  104.472 1.00 98.32  ? 201 LEU A N   1 
ATOM   1123 C CA  . LEU A 1 201 ? 90.931  98.097  103.468 1.00 105.29 ? 201 LEU A CA  1 
ATOM   1124 C C   . LEU A 1 201 ? 91.767  99.270  103.991 1.00 95.82  ? 201 LEU A C   1 
ATOM   1125 O O   . LEU A 1 201 ? 92.798  99.595  103.397 1.00 116.31 ? 201 LEU A O   1 
ATOM   1126 C CB  . LEU A 1 201 ? 90.138  98.453  102.208 1.00 99.50  ? 201 LEU A CB  1 
ATOM   1127 C CG  . LEU A 1 201 ? 89.551  97.240  101.488 1.00 98.25  ? 201 LEU A CG  1 
ATOM   1128 C CD1 . LEU A 1 201 ? 88.538  97.674  100.466 1.00 112.13 ? 201 LEU A CD1 1 
ATOM   1129 C CD2 . LEU A 1 201 ? 90.617  96.400  100.821 1.00 109.71 ? 201 LEU A CD2 1 
ATOM   1130 N N   . GLY A 1 202 ? 91.364  99.889  105.102 1.00 96.90  ? 202 GLY A N   1 
ATOM   1131 C CA  . GLY A 1 202 ? 92.239  100.829 105.791 1.00 126.88 ? 202 GLY A CA  1 
ATOM   1132 C C   . GLY A 1 202 ? 93.505  100.157 106.335 1.00 126.27 ? 202 GLY A C   1 
ATOM   1133 O O   . GLY A 1 202 ? 94.494  100.837 106.626 1.00 101.32 ? 202 GLY A O   1 
ATOM   1134 N N   . GLN A 1 203 ? 93.446  98.826  106.496 1.00 122.77 ? 203 GLN A N   1 
ATOM   1135 C CA  . GLN A 1 203 ? 94.565  98.030  106.971 1.00 119.31 ? 203 GLN A CA  1 
ATOM   1136 C C   . GLN A 1 203 ? 95.405  97.516  105.795 1.00 97.39  ? 203 GLN A C   1 
ATOM   1137 O O   . GLN A 1 203 ? 96.609  97.331  105.964 1.00 107.78 ? 203 GLN A O   1 
ATOM   1138 C CB  . GLN A 1 203 ? 94.058  96.901  107.870 1.00 117.49 ? 203 GLN A CB  1 
ATOM   1139 C CG  . GLN A 1 203 ? 95.123  96.386  108.831 1.00 127.94 ? 203 GLN A CG  1 
ATOM   1140 C CD  . GLN A 1 203 ? 94.740  95.087  109.499 1.00 138.45 ? 203 GLN A CD  1 
ATOM   1141 O OE1 . GLN A 1 203 ? 93.589  94.654  109.446 1.00 145.13 ? 203 GLN A OE1 1 
ATOM   1142 N NE2 . GLN A 1 203 ? 95.719  94.448  110.123 1.00 150.24 ? 203 GLN A NE2 1 
ATOM   1143 N N   . VAL A 1 204 ? 94.811  97.324  104.612 1.00 81.33  ? 204 VAL A N   1 
ATOM   1144 C CA  . VAL A 1 204 ? 95.563  96.932  103.424 1.00 93.07  ? 204 VAL A CA  1 
ATOM   1145 C C   . VAL A 1 204 ? 96.531  98.042  102.998 1.00 85.64  ? 204 VAL A C   1 
ATOM   1146 O O   . VAL A 1 204 ? 97.672  97.746  102.658 1.00 96.11  ? 204 VAL A O   1 
ATOM   1147 C CB  . VAL A 1 204 ? 94.636  96.482  102.270 1.00 101.85 ? 204 VAL A CB  1 
ATOM   1148 C CG1 . VAL A 1 204 ? 95.336  96.421  100.916 1.00 100.08 ? 204 VAL A CG1 1 
ATOM   1149 C CG2 . VAL A 1 204 ? 93.999  95.137  102.589 1.00 112.85 ? 204 VAL A CG2 1 
ATOM   1150 N N   . THR A 1 205 ? 96.135  99.317  103.052 1.00 88.57  ? 205 THR A N   1 
ATOM   1151 C CA  . THR A 1 205 ? 97.065  100.386 102.691 1.00 89.15  ? 205 THR A CA  1 
ATOM   1152 C C   . THR A 1 205 ? 98.128  100.583 103.775 1.00 87.55  ? 205 THR A C   1 
ATOM   1153 O O   . THR A 1 205 ? 99.124  101.247 103.511 1.00 100.29 ? 205 THR A O   1 
ATOM   1154 C CB  . THR A 1 205 ? 96.373  101.731 102.408 1.00 99.88  ? 205 THR A CB  1 
ATOM   1155 O OG1 . THR A 1 205 ? 95.746  102.244 103.587 1.00 116.76 ? 205 THR A OG1 1 
ATOM   1156 C CG2 . THR A 1 205 ? 95.304  101.627 101.343 1.00 122.54 ? 205 THR A CG2 1 
ATOM   1157 N N   . ALA A 1 206 ? 97.915  100.044 104.992 1.00 76.78  ? 206 ALA A N   1 
ATOM   1158 C CA  . ALA A 1 206 ? 98.891  100.107 106.073 1.00 69.27  ? 206 ALA A CA  1 
ATOM   1159 C C   . ALA A 1 206 ? 99.914  98.980  105.958 1.00 63.41  ? 206 ALA A C   1 
ATOM   1160 O O   . ALA A 1 206 ? 101.109 99.224  106.135 1.00 59.29  ? 206 ALA A O   1 
ATOM   1161 C CB  . ALA A 1 206 ? 98.191  100.074 107.404 1.00 85.72  ? 206 ALA A CB  1 
ATOM   1162 N N   . ILE A 1 207 ? 99.452  97.756  105.646 1.00 70.72  ? 207 ILE A N   1 
ATOM   1163 C CA  . ILE A 1 207 ? 100.314 96.594  105.478 1.00 63.99  ? 207 ILE A CA  1 
ATOM   1164 C C   . ILE A 1 207 ? 101.282 96.812  104.324 1.00 67.76  ? 207 ILE A C   1 
ATOM   1165 O O   . ILE A 1 207 ? 102.464 96.500  104.466 1.00 76.40  ? 207 ILE A O   1 
ATOM   1166 C CB  . ILE A 1 207 ? 99.484  95.309  105.303 1.00 73.40  ? 207 ILE A CB  1 
ATOM   1167 C CG1 . ILE A 1 207 ? 98.825  94.915  106.631 1.00 83.20  ? 207 ILE A CG1 1 
ATOM   1168 C CG2 . ILE A 1 207 ? 100.336 94.172  104.751 1.00 82.22  ? 207 ILE A CG2 1 
ATOM   1169 C CD1 . ILE A 1 207 ? 97.686  93.932  106.494 1.00 90.73  ? 207 ILE A CD1 1 
ATOM   1170 N N   . PHE A 1 208 ? 100.815 97.355  103.192 1.00 73.95  ? 208 PHE A N   1 
ATOM   1171 C CA  . PHE A 1 208 ? 101.692 97.516  102.038 1.00 75.88  ? 208 PHE A CA  1 
ATOM   1172 C C   . PHE A 1 208 ? 102.762 98.582  102.272 1.00 67.90  ? 208 PHE A C   1 
ATOM   1173 O O   . PHE A 1 208 ? 103.835 98.475  101.688 1.00 79.35  ? 208 PHE A O   1 
ATOM   1174 C CB  . PHE A 1 208 ? 100.887 97.763  100.765 1.00 88.79  ? 208 PHE A CB  1 
ATOM   1175 C CG  . PHE A 1 208 ? 100.543 96.496  100.026 1.00 96.00  ? 208 PHE A CG  1 
ATOM   1176 C CD1 . PHE A 1 208 ? 101.452 95.931  99.147  1.00 117.19 ? 208 PHE A CD1 1 
ATOM   1177 C CD2 . PHE A 1 208 ? 99.341  95.848  100.249 1.00 93.87  ? 208 PHE A CD2 1 
ATOM   1178 C CE1 . PHE A 1 208 ? 101.142 94.766  98.463  1.00 129.72 ? 208 PHE A CE1 1 
ATOM   1179 C CE2 . PHE A 1 208 ? 99.038  94.677  99.577  1.00 109.19 ? 208 PHE A CE2 1 
ATOM   1180 C CZ  . PHE A 1 208 ? 99.942  94.135  98.696  1.00 122.51 ? 208 PHE A CZ  1 
ATOM   1181 N N   . ILE A 1 209 ? 102.521 99.568  103.144 1.00 59.87  ? 209 ILE A N   1 
ATOM   1182 C CA  . ILE A 1 209 ? 103.581 100.489 103.544 1.00 54.36  ? 209 ILE A CA  1 
ATOM   1183 C C   . ILE A 1 209 ? 104.685 99.739  104.290 1.00 58.19  ? 209 ILE A C   1 
ATOM   1184 O O   . ILE A 1 209 ? 105.862 99.948  104.017 1.00 63.62  ? 209 ILE A O   1 
ATOM   1185 C CB  . ILE A 1 209 ? 103.021 101.683 104.336 1.00 58.56  ? 209 ILE A CB  1 
ATOM   1186 C CG1 . ILE A 1 209 ? 102.159 102.565 103.425 1.00 63.77  ? 209 ILE A CG1 1 
ATOM   1187 C CG2 . ILE A 1 209 ? 104.146 102.474 104.995 1.00 60.81  ? 209 ILE A CG2 1 
ATOM   1188 C CD1 . ILE A 1 209 ? 101.365 103.646 104.098 1.00 60.92  ? 209 ILE A CD1 1 
ATOM   1189 N N   . CYS A 1 210 ? 104.304 98.806  105.177 1.00 62.49  ? 210 CYS A N   1 
ATOM   1190 C CA  . CYS A 1 210 ? 105.247 98.031  105.960 1.00 63.24  ? 210 CYS A CA  1 
ATOM   1191 C C   . CYS A 1 210 ? 106.054 97.058  105.092 1.00 64.34  ? 210 CYS A C   1 
ATOM   1192 O O   . CYS A 1 210 ? 107.263 96.908  105.302 1.00 59.98  ? 210 CYS A O   1 
ATOM   1193 C CB  . CYS A 1 210 ? 104.510 97.295  107.062 1.00 67.54  ? 210 CYS A CB  1 
ATOM   1194 S SG  . CYS A 1 210 ? 103.533 98.438  108.062 1.00 82.03  ? 210 CYS A SG  1 
ATOM   1195 N N   . ILE A 1 211 ? 105.402 96.381  104.135 1.00 56.92  ? 211 ILE A N   1 
ATOM   1196 C CA  . ILE A 1 211 ? 106.106 95.541  103.169 1.00 57.03  ? 211 ILE A CA  1 
ATOM   1197 C C   . ILE A 1 211 ? 107.052 96.403  102.330 1.00 51.25  ? 211 ILE A C   1 
ATOM   1198 O O   . ILE A 1 211 ? 108.092 95.928  101.873 1.00 43.31  ? 211 ILE A O   1 
ATOM   1199 C CB  . ILE A 1 211 ? 105.107 94.748  102.308 1.00 58.35  ? 211 ILE A CB  1 
ATOM   1200 C CG1 . ILE A 1 211 ? 104.277 93.778  103.137 1.00 65.93  ? 211 ILE A CG1 1 
ATOM   1201 C CG2 . ILE A 1 211 ? 105.812 94.012  101.192 1.00 68.08  ? 211 ILE A CG2 1 
ATOM   1202 C CD1 . ILE A 1 211 ? 103.111 93.193  102.359 1.00 80.72  ? 211 ILE A CD1 1 
ATOM   1203 N N   . GLY A 1 212 ? 106.692 97.682  102.147 1.00 54.17  ? 212 GLY A N   1 
ATOM   1204 C CA  . GLY A 1 212 ? 107.568 98.688  101.556 1.00 52.35  ? 212 GLY A CA  1 
ATOM   1205 C C   . GLY A 1 212 ? 108.820 98.944  102.386 1.00 51.04  ? 212 GLY A C   1 
ATOM   1206 O O   . GLY A 1 212 ? 109.914 98.758  101.872 1.00 57.56  ? 212 GLY A O   1 
ATOM   1207 N N   . VAL A 1 213 ? 108.678 99.331  103.673 1.00 55.42  ? 213 VAL A N   1 
ATOM   1208 C CA  . VAL A 1 213 ? 109.848 99.642  104.493 1.00 56.75  ? 213 VAL A CA  1 
ATOM   1209 C C   . VAL A 1 213 ? 110.733 98.402  104.636 1.00 51.75  ? 213 VAL A C   1 
ATOM   1210 O O   . VAL A 1 213 ? 111.946 98.543  104.606 1.00 57.72  ? 213 VAL A O   1 
ATOM   1211 C CB  . VAL A 1 213 ? 109.576 100.312 105.859 1.00 48.00  ? 213 VAL A CB  1 
ATOM   1212 C CG1 . VAL A 1 213 ? 108.325 101.164 105.860 1.00 42.70  ? 213 VAL A CG1 1 
ATOM   1213 C CG2 . VAL A 1 213 ? 109.539 99.339  107.014 1.00 64.16  ? 213 VAL A CG2 1 
ATOM   1214 N N   . PHE A 1 214 ? 110.142 97.212  104.748 1.00 48.21  ? 214 PHE A N   1 
ATOM   1215 C CA  . PHE A 1 214 ? 110.910 95.978  104.806 1.00 52.86  ? 214 PHE A CA  1 
ATOM   1216 C C   . PHE A 1 214 ? 111.707 95.764  103.521 1.00 49.82  ? 214 PHE A C   1 
ATOM   1217 O O   . PHE A 1 214 ? 112.887 95.430  103.582 1.00 62.32  ? 214 PHE A O   1 
ATOM   1218 C CB  . PHE A 1 214 ? 110.004 94.777  105.093 1.00 55.31  ? 214 PHE A CB  1 
ATOM   1219 C CG  . PHE A 1 214 ? 110.736 93.461  105.148 1.00 57.83  ? 214 PHE A CG  1 
ATOM   1220 C CD1 . PHE A 1 214 ? 111.473 93.105  106.265 1.00 64.80  ? 214 PHE A CD1 1 
ATOM   1221 C CD2 . PHE A 1 214 ? 110.726 92.596  104.070 1.00 64.78  ? 214 PHE A CD2 1 
ATOM   1222 C CE1 . PHE A 1 214 ? 112.147 91.895  106.313 1.00 64.62  ? 214 PHE A CE1 1 
ATOM   1223 C CE2 . PHE A 1 214 ? 111.429 91.403  104.112 1.00 77.23  ? 214 PHE A CE2 1 
ATOM   1224 C CZ  . PHE A 1 214 ? 112.115 91.039  105.245 1.00 69.22  ? 214 PHE A CZ  1 
ATOM   1225 N N   . THR A 1 215 ? 111.088 95.939  102.346 1.00 55.95  ? 215 THR A N   1 
ATOM   1226 C CA  . THR A 1 215 ? 111.765 95.683  101.075 1.00 52.86  ? 215 THR A CA  1 
ATOM   1227 C C   . THR A 1 215 ? 112.913 96.673  100.843 1.00 53.26  ? 215 THR A C   1 
ATOM   1228 O O   . THR A 1 215 ? 113.947 96.281  100.319 1.00 55.31  ? 215 THR A O   1 
ATOM   1229 C CB  . THR A 1 215 ? 110.798 95.716  99.892  1.00 50.69  ? 215 THR A CB  1 
ATOM   1230 O OG1 . THR A 1 215 ? 109.793 94.741  100.156 1.00 58.31  ? 215 THR A OG1 1 
ATOM   1231 C CG2 . THR A 1 215 ? 111.471 95.413  98.575  1.00 65.37  ? 215 THR A CG2 1 
ATOM   1232 N N   . GLY A 1 216 ? 112.755 97.940  101.250 1.00 51.25  ? 216 GLY A N   1 
ATOM   1233 C CA  . GLY A 1 216 ? 113.843 98.901  101.223 1.00 49.34  ? 216 GLY A CA  1 
ATOM   1234 C C   . GLY A 1 216 ? 115.038 98.448  102.056 1.00 55.42  ? 216 GLY A C   1 
ATOM   1235 O O   . GLY A 1 216 ? 116.185 98.633  101.639 1.00 69.84  ? 216 GLY A O   1 
ATOM   1236 N N   . GLN A 1 217 ? 114.772 97.861  103.237 1.00 52.18  ? 217 GLN A N   1 
ATOM   1237 C CA  . GLN A 1 217 ? 115.798 97.347  104.127 1.00 49.95  ? 217 GLN A CA  1 
ATOM   1238 C C   . GLN A 1 217 ? 116.414 96.044  103.622 1.00 54.98  ? 217 GLN A C   1 
ATOM   1239 O O   . GLN A 1 217 ? 117.594 95.796  103.883 1.00 67.88  ? 217 GLN A O   1 
ATOM   1240 C CB  . GLN A 1 217 ? 115.213 97.112  105.510 1.00 50.95  ? 217 GLN A CB  1 
ATOM   1241 C CG  . GLN A 1 217 ? 114.868 98.405  106.233 1.00 62.01  ? 217 GLN A CG  1 
ATOM   1242 C CD  . GLN A 1 217 ? 114.255 98.152  107.593 1.00 65.47  ? 217 GLN A CD  1 
ATOM   1243 O OE1 . GLN A 1 217 ? 113.798 97.061  107.896 1.00 66.63  ? 217 GLN A OE1 1 
ATOM   1244 N NE2 . GLN A 1 217 ? 114.236 99.170  108.430 1.00 74.95  ? 217 GLN A NE2 1 
ATOM   1245 N N   . LEU A 1 218 ? 115.629 95.215  102.926 1.00 53.02  ? 218 LEU A N   1 
ATOM   1246 C CA  . LEU A 1 218 ? 116.116 93.990  102.315 1.00 59.23  ? 218 LEU A CA  1 
ATOM   1247 C C   . LEU A 1 218 ? 117.050 94.279  101.130 1.00 67.48  ? 218 LEU A C   1 
ATOM   1248 O O   . LEU A 1 218 ? 118.157 93.752  101.113 1.00 75.75  ? 218 LEU A O   1 
ATOM   1249 C CB  . LEU A 1 218 ? 114.914 93.137  101.914 1.00 60.85  ? 218 LEU A CB  1 
ATOM   1250 C CG  . LEU A 1 218 ? 115.256 91.772  101.332 1.00 70.56  ? 218 LEU A CG  1 
ATOM   1251 C CD1 . LEU A 1 218 ? 115.835 90.869  102.383 1.00 70.57  ? 218 LEU A CD1 1 
ATOM   1252 C CD2 . LEU A 1 218 ? 114.018 91.125  100.747 1.00 93.87  ? 218 LEU A CD2 1 
ATOM   1253 N N   . LEU A 1 219 ? 116.665 95.104  100.143 1.00 66.26  ? 219 LEU A N   1 
ATOM   1254 C CA  . LEU A 1 219 ? 117.545 95.412  99.013  1.00 64.95  ? 219 LEU A CA  1 
ATOM   1255 C C   . LEU A 1 219 ? 118.827 96.134  99.450  1.00 61.03  ? 219 LEU A C   1 
ATOM   1256 O O   . LEU A 1 219 ? 119.861 95.985  98.809  1.00 65.84  ? 219 LEU A O   1 
ATOM   1257 C CB  . LEU A 1 219 ? 116.806 96.231  97.951  1.00 60.70  ? 219 LEU A CB  1 
ATOM   1258 C CG  . LEU A 1 219 ? 115.649 95.548  97.230  1.00 62.85  ? 219 LEU A CG  1 
ATOM   1259 C CD1 . LEU A 1 219 ? 115.165 96.379  96.075  1.00 68.56  ? 219 LEU A CD1 1 
ATOM   1260 C CD2 . LEU A 1 219 ? 116.053 94.198  96.716  1.00 67.27  ? 219 LEU A CD2 1 
ATOM   1261 N N   . GLY A 1 220 ? 118.768 96.891  100.545 1.00 60.14  ? 220 GLY A N   1 
ATOM   1262 C CA  . GLY A 1 220 ? 119.920 97.588  101.101 1.00 56.60  ? 220 GLY A CA  1 
ATOM   1263 C C   . GLY A 1 220 ? 120.915 96.697  101.852 1.00 59.66  ? 220 GLY A C   1 
ATOM   1264 O O   . GLY A 1 220 ? 121.892 97.221  102.377 1.00 75.41  ? 220 GLY A O   1 
ATOM   1265 N N   . LEU A 1 221 ? 120.715 95.371  101.925 1.00 61.47  ? 221 LEU A N   1 
ATOM   1266 C CA  . LEU A 1 221 ? 121.734 94.470  102.458 1.00 57.56  ? 221 LEU A CA  1 
ATOM   1267 C C   . LEU A 1 221 ? 122.962 94.501  101.544 1.00 74.05  ? 221 LEU A C   1 
ATOM   1268 O O   . LEU A 1 221 ? 122.831 94.630  100.324 1.00 74.89  ? 221 LEU A O   1 
ATOM   1269 C CB  . LEU A 1 221 ? 121.183 93.040  102.508 1.00 56.93  ? 221 LEU A CB  1 
ATOM   1270 C CG  . LEU A 1 221 ? 120.170 92.690  103.585 1.00 58.13  ? 221 LEU A CG  1 
ATOM   1271 C CD1 . LEU A 1 221 ? 119.797 91.236  103.470 1.00 67.42  ? 221 LEU A CD1 1 
ATOM   1272 C CD2 . LEU A 1 221 ? 120.699 92.937  104.971 1.00 67.86  ? 221 LEU A CD2 1 
ATOM   1273 N N   . PRO A 1 222 ? 124.196 94.304  102.077 1.00 79.33  ? 222 PRO A N   1 
ATOM   1274 C CA  . PRO A 1 222 ? 125.406 94.340  101.259 1.00 85.38  ? 222 PRO A CA  1 
ATOM   1275 C C   . PRO A 1 222 ? 125.562 93.169  100.291 1.00 91.95  ? 222 PRO A C   1 
ATOM   1276 O O   . PRO A 1 222 ? 126.428 93.218  99.409  1.00 124.81 ? 222 PRO A O   1 
ATOM   1277 C CB  . PRO A 1 222 ? 126.541 94.364  102.292 1.00 99.50  ? 222 PRO A CB  1 
ATOM   1278 C CG  . PRO A 1 222 ? 125.952 93.698  103.502 1.00 96.56  ? 222 PRO A CG  1 
ATOM   1279 C CD  . PRO A 1 222 ? 124.490 94.088  103.496 1.00 81.81  ? 222 PRO A CD  1 
ATOM   1280 N N   . GLU A 1 223 ? 124.704 92.145  100.425 1.00 91.55  ? 223 GLU A N   1 
ATOM   1281 C CA  . GLU A 1 223 ? 124.661 91.011  99.507  1.00 103.16 ? 223 GLU A CA  1 
ATOM   1282 C C   . GLU A 1 223 ? 123.760 91.268  98.297  1.00 82.45  ? 223 GLU A C   1 
ATOM   1283 O O   . GLU A 1 223 ? 123.874 90.556  97.303  1.00 86.36  ? 223 GLU A O   1 
ATOM   1284 C CB  . GLU A 1 223 ? 124.206 89.772  100.273 1.00 112.08 ? 223 GLU A CB  1 
ATOM   1285 C CG  . GLU A 1 223 ? 125.203 89.360  101.326 1.00 135.64 ? 223 GLU A CG  1 
ATOM   1286 C CD  . GLU A 1 223 ? 124.768 88.192  102.185 1.00 192.73 ? 223 GLU A CD  1 
ATOM   1287 O OE1 . GLU A 1 223 ? 124.462 87.122  101.619 1.00 231.67 ? 223 GLU A OE1 1 
ATOM   1288 O OE2 . GLU A 1 223 ? 124.751 88.353  103.416 1.00 227.64 ? 223 GLU A OE2 1 
ATOM   1289 N N   . LEU A 1 224 ? 122.850 92.253  98.392  1.00 83.06  ? 224 LEU A N   1 
ATOM   1290 C CA  . LEU A 1 224 ? 122.036 92.694  97.260  1.00 82.64  ? 224 LEU A CA  1 
ATOM   1291 C C   . LEU A 1 224 ? 122.585 94.020  96.692  1.00 73.42  ? 224 LEU A C   1 
ATOM   1292 O O   . LEU A 1 224 ? 123.651 93.993  96.075  1.00 90.35  ? 224 LEU A O   1 
ATOM   1293 C CB  . LEU A 1 224 ? 120.565 92.765  97.705  1.00 74.34  ? 224 LEU A CB  1 
ATOM   1294 C CG  . LEU A 1 224 ? 119.920 91.422  98.028  1.00 76.36  ? 224 LEU A CG  1 
ATOM   1295 C CD1 . LEU A 1 224 ? 118.462 91.593  98.375  1.00 80.66  ? 224 LEU A CD1 1 
ATOM   1296 C CD2 . LEU A 1 224 ? 120.024 90.450  96.866  1.00 100.09 ? 224 LEU A CD2 1 
ATOM   1297 N N   . LEU A 1 225 ? 121.900 95.160  96.887  1.00 53.66  ? 225 LEU A N   1 
ATOM   1298 C CA  . LEU A 1 225 ? 122.235 96.385  96.180  1.00 63.98  ? 225 LEU A CA  1 
ATOM   1299 C C   . LEU A 1 225 ? 122.973 97.422  97.055  1.00 73.49  ? 225 LEU A C   1 
ATOM   1300 O O   . LEU A 1 225 ? 123.494 98.405  96.528  1.00 74.88  ? 225 LEU A O   1 
ATOM   1301 C CB  . LEU A 1 225 ? 120.942 96.974  95.600  1.00 65.76  ? 225 LEU A CB  1 
ATOM   1302 C CG  . LEU A 1 225 ? 120.664 96.665  94.130  1.00 58.75  ? 225 LEU A CG  1 
ATOM   1303 C CD1 . LEU A 1 225 ? 120.802 95.204  93.830  1.00 65.90  ? 225 LEU A CD1 1 
ATOM   1304 C CD2 . LEU A 1 225 ? 119.277 97.155  93.762  1.00 61.08  ? 225 LEU A CD2 1 
ATOM   1305 N N   . GLY A 1 226 ? 123.081 97.212  98.366  1.00 76.26  ? 226 GLY A N   1 
ATOM   1306 C CA  . GLY A 1 226 ? 123.686 98.194  99.253  1.00 75.56  ? 226 GLY A CA  1 
ATOM   1307 C C   . GLY A 1 226 ? 125.221 98.140  99.295  1.00 73.16  ? 226 GLY A C   1 
ATOM   1308 O O   . GLY A 1 226 ? 125.822 98.290  100.359 1.00 91.60  ? 226 GLY A O   1 
ATOM   1309 N N   . LYS A 1 227 ? 125.855 98.011  98.125  1.00 65.97  ? 227 LYS A N   1 
ATOM   1310 C CA  . LYS A 1 227 ? 127.300 98.082  97.962  1.00 70.79  ? 227 LYS A CA  1 
ATOM   1311 C C   . LYS A 1 227 ? 127.709 99.460  97.432  1.00 74.61  ? 227 LYS A C   1 
ATOM   1312 O O   . LYS A 1 227 ? 126.902 100.194 96.876  1.00 77.80  ? 227 LYS A O   1 
ATOM   1313 C CB  . LYS A 1 227 ? 127.768 97.057  96.920  1.00 86.74  ? 227 LYS A CB  1 
ATOM   1314 C CG  . LYS A 1 227 ? 127.368 95.612  97.159  1.00 101.35 ? 227 LYS A CG  1 
ATOM   1315 C CD  . LYS A 1 227 ? 127.643 94.760  95.952  1.00 127.82 ? 227 LYS A CD  1 
ATOM   1316 C CE  . LYS A 1 227 ? 127.195 93.328  96.139  1.00 158.90 ? 227 LYS A CE  1 
ATOM   1317 N NZ  . LYS A 1 227 ? 127.382 92.540  94.896  1.00 173.55 ? 227 LYS A NZ  1 
ATOM   1318 N N   . GLU A 1 228 ? 129.009 99.766  97.477  1.00 90.35  ? 228 GLU A N   1 
ATOM   1319 C CA  . GLU A 1 228 ? 129.522 101.053 97.025  1.00 97.09  ? 228 GLU A CA  1 
ATOM   1320 C C   . GLU A 1 228 ? 129.300 101.227 95.519  1.00 100.07 ? 228 GLU A C   1 
ATOM   1321 O O   . GLU A 1 228 ? 128.994 102.327 95.056  1.00 121.01 ? 228 GLU A O   1 
ATOM   1322 C CB  . GLU A 1 228 ? 131.008 101.160 97.371  1.00 121.01 ? 228 GLU A CB  1 
ATOM   1323 C CG  . GLU A 1 228 ? 131.644 102.484 96.989  1.00 147.88 ? 228 GLU A CG  1 
ATOM   1324 C CD  . GLU A 1 228 ? 133.146 102.545 97.206  1.00 193.23 ? 228 GLU A CD  1 
ATOM   1325 O OE1 . GLU A 1 228 ? 133.691 101.636 97.868  1.00 218.99 ? 228 GLU A OE1 1 
ATOM   1326 O OE2 . GLU A 1 228 ? 133.769 103.489 96.694  1.00 218.80 ? 228 GLU A OE2 1 
ATOM   1327 N N   . SER A 1 229 ? 129.437 100.140 94.744  1.00 101.16 ? 229 SER A N   1 
ATOM   1328 C CA  . SER A 1 229 ? 129.393 100.178 93.284  1.00 104.19 ? 229 SER A CA  1 
ATOM   1329 C C   . SER A 1 229 ? 127.982 100.033 92.707  1.00 83.11  ? 229 SER A C   1 
ATOM   1330 O O   . SER A 1 229 ? 127.821 100.134 91.494  1.00 101.29 ? 229 SER A O   1 
ATOM   1331 C CB  . SER A 1 229 ? 130.310 99.121  92.701  1.00 118.91 ? 229 SER A CB  1 
ATOM   1332 O OG  . SER A 1 229 ? 129.977 97.829  93.186  1.00 116.18 ? 229 SER A OG  1 
ATOM   1333 N N   . THR A 1 230 ? 126.959 99.804  93.554  1.00 75.48  ? 230 THR A N   1 
ATOM   1334 C CA  . THR A 1 230 ? 125.595 99.568  93.092  1.00 68.38  ? 230 THR A CA  1 
ATOM   1335 C C   . THR A 1 230 ? 124.538 100.344 93.891  1.00 57.64  ? 230 THR A C   1 
ATOM   1336 O O   . THR A 1 230 ? 123.348 100.092 93.721  1.00 65.55  ? 230 THR A O   1 
ATOM   1337 C CB  . THR A 1 230 ? 125.219 98.077  93.113  1.00 67.83  ? 230 THR A CB  1 
ATOM   1338 O OG1 . THR A 1 230 ? 125.176 97.587  94.451  1.00 57.47  ? 230 THR A OG1 1 
ATOM   1339 C CG2 . THR A 1 230 ? 126.164 97.224  92.296  1.00 86.45  ? 230 THR A CG2 1 
ATOM   1340 N N   . TRP A 1 231 ? 124.916 101.347 94.676  1.00 46.90  ? 231 TRP A N   1 
ATOM   1341 C CA  . TRP A 1 231 ? 123.907 102.098 95.409  1.00 52.83  ? 231 TRP A CA  1 
ATOM   1342 C C   . TRP A 1 231 ? 122.941 102.839 94.487  1.00 58.05  ? 231 TRP A C   1 
ATOM   1343 O O   . TRP A 1 231 ? 121.771 102.944 94.846  1.00 64.73  ? 231 TRP A O   1 
ATOM   1344 C CB  . TRP A 1 231 ? 124.513 103.011 96.500  1.00 62.50  ? 231 TRP A CB  1 
ATOM   1345 C CG  . TRP A 1 231 ? 125.237 104.258 96.050  1.00 62.19  ? 231 TRP A CG  1 
ATOM   1346 C CD1 . TRP A 1 231 ? 126.589 104.392 95.947  1.00 55.25  ? 231 TRP A CD1 1 
ATOM   1347 C CD2 . TRP A 1 231 ? 124.678 105.552 95.712  1.00 66.77  ? 231 TRP A CD2 1 
ATOM   1348 N NE1 . TRP A 1 231 ? 126.911 105.660 95.552  1.00 64.83  ? 231 TRP A NE1 1 
ATOM   1349 C CE2 . TRP A 1 231 ? 125.764 106.401 95.392  1.00 68.59  ? 231 TRP A CE2 1 
ATOM   1350 C CE3 . TRP A 1 231 ? 123.380 106.075 95.614  1.00 73.20  ? 231 TRP A CE3 1 
ATOM   1351 C CZ2 . TRP A 1 231 ? 125.586 107.737 95.004  1.00 70.76  ? 231 TRP A CZ2 1 
ATOM   1352 C CZ3 . TRP A 1 231 ? 123.205 107.383 95.210  1.00 83.81  ? 231 TRP A CZ3 1 
ATOM   1353 C CH2 . TRP A 1 231 ? 124.295 108.205 94.916  1.00 81.19  ? 231 TRP A CH2 1 
ATOM   1354 N N   . PRO A 1 232 ? 123.308 103.366 93.283  1.00 63.09  ? 232 PRO A N   1 
ATOM   1355 C CA  . PRO A 1 232 ? 122.335 104.047 92.424  1.00 57.79  ? 232 PRO A CA  1 
ATOM   1356 C C   . PRO A 1 232 ? 121.124 103.205 91.999  1.00 60.94  ? 232 PRO A C   1 
ATOM   1357 O O   . PRO A 1 232 ? 120.055 103.752 91.749  1.00 63.63  ? 232 PRO A O   1 
ATOM   1358 C CB  . PRO A 1 232 ? 123.151 104.447 91.195  1.00 55.00  ? 232 PRO A CB  1 
ATOM   1359 C CG  . PRO A 1 232 ? 124.536 104.564 91.716  1.00 61.45  ? 232 PRO A CG  1 
ATOM   1360 C CD  . PRO A 1 232 ? 124.657 103.425 92.706  1.00 66.80  ? 232 PRO A CD  1 
ATOM   1361 N N   . TYR A 1 233 ? 121.275 101.874 91.941  1.00 52.48  ? 233 TYR A N   1 
ATOM   1362 C CA  . TYR A 1 233 ? 120.166 101.015 91.590  1.00 53.08  ? 233 TYR A CA  1 
ATOM   1363 C C   . TYR A 1 233 ? 119.121 100.927 92.703  1.00 49.38  ? 233 TYR A C   1 
ATOM   1364 O O   . TYR A 1 233 ? 117.987 100.578 92.421  1.00 63.82  ? 233 TYR A O   1 
ATOM   1365 C CB  . TYR A 1 233 ? 120.672 99.628  91.224  1.00 61.94  ? 233 TYR A CB  1 
ATOM   1366 C CG  . TYR A 1 233 ? 121.647 99.617  90.062  1.00 65.37  ? 233 TYR A CG  1 
ATOM   1367 C CD1 . TYR A 1 233 ? 121.245 99.771  88.753  1.00 76.62  ? 233 TYR A CD1 1 
ATOM   1368 C CD2 . TYR A 1 233 ? 122.987 99.437  90.295  1.00 89.46  ? 233 TYR A CD2 1 
ATOM   1369 C CE1 . TYR A 1 233 ? 122.149 99.735  87.706  1.00 86.76  ? 233 TYR A CE1 1 
ATOM   1370 C CE2 . TYR A 1 233 ? 123.905 99.347  89.256  1.00 103.45 ? 233 TYR A CE2 1 
ATOM   1371 C CZ  . TYR A 1 233 ? 123.488 99.515  87.953  1.00 93.49  ? 233 TYR A CZ  1 
ATOM   1372 O OH  . TYR A 1 233 ? 124.409 99.460  86.942  1.00 102.24 ? 233 TYR A OH  1 
ATOM   1373 N N   . LEU A 1 234 ? 119.445 101.258 93.958  1.00 60.02  ? 234 LEU A N   1 
ATOM   1374 C CA  . LEU A 1 234 ? 118.440 101.308 95.014  1.00 61.08  ? 234 LEU A CA  1 
ATOM   1375 C C   . LEU A 1 234 ? 117.327 102.304 94.668  1.00 60.10  ? 234 LEU A C   1 
ATOM   1376 O O   . LEU A 1 234 ? 116.167 102.052 94.986  1.00 58.61  ? 234 LEU A O   1 
ATOM   1377 C CB  . LEU A 1 234 ? 119.095 101.687 96.345  1.00 61.43  ? 234 LEU A CB  1 
ATOM   1378 C CG  . LEU A 1 234 ? 120.017 100.639 96.953  1.00 65.58  ? 234 LEU A CG  1 
ATOM   1379 C CD1 . LEU A 1 234 ? 120.780 101.248 98.126  1.00 76.70  ? 234 LEU A CD1 1 
ATOM   1380 C CD2 . LEU A 1 234 ? 119.243 99.432  97.420  1.00 67.02  ? 234 LEU A CD2 1 
ATOM   1381 N N   . PHE A 1 235 ? 117.677 103.409 94.001  1.00 62.27  ? 235 PHE A N   1 
ATOM   1382 C CA  . PHE A 1 235 ? 116.711 104.400 93.534  1.00 69.29  ? 235 PHE A CA  1 
ATOM   1383 C C   . PHE A 1 235 ? 116.201 104.057 92.128  1.00 65.55  ? 235 PHE A C   1 
ATOM   1384 O O   . PHE A 1 235 ? 115.045 104.292 91.822  1.00 65.17  ? 235 PHE A O   1 
ATOM   1385 C CB  . PHE A 1 235 ? 117.330 105.797 93.572  1.00 67.72  ? 235 PHE A CB  1 
ATOM   1386 C CG  . PHE A 1 235 ? 117.866 106.166 94.929  1.00 72.02  ? 235 PHE A CG  1 
ATOM   1387 C CD1 . PHE A 1 235 ? 117.003 106.415 95.973  1.00 67.86  ? 235 PHE A CD1 1 
ATOM   1388 C CD2 . PHE A 1 235 ? 119.228 106.208 95.176  1.00 80.85  ? 235 PHE A CD2 1 
ATOM   1389 C CE1 . PHE A 1 235 ? 117.481 106.749 97.226  1.00 74.62  ? 235 PHE A CE1 1 
ATOM   1390 C CE2 . PHE A 1 235 ? 119.700 106.522 96.440  1.00 81.58  ? 235 PHE A CE2 1 
ATOM   1391 C CZ  . PHE A 1 235 ? 118.828 106.773 97.464  1.00 80.26  ? 235 PHE A CZ  1 
ATOM   1392 N N   . GLY A 1 236 ? 117.055 103.492 91.278  1.00 71.06  ? 236 GLY A N   1 
ATOM   1393 C CA  . GLY A 1 236 ? 116.659 103.098 89.939  1.00 76.95  ? 236 GLY A CA  1 
ATOM   1394 C C   . GLY A 1 236 ? 115.591 102.002 89.884  1.00 65.31  ? 236 GLY A C   1 
ATOM   1395 O O   . GLY A 1 236 ? 114.842 101.940 88.921  1.00 70.29  ? 236 GLY A O   1 
ATOM   1396 N N   . VAL A 1 237 ? 115.542 101.104 90.876  1.00 77.88  ? 237 VAL A N   1 
ATOM   1397 C CA  . VAL A 1 237 ? 114.603 99.976  90.925  1.00 71.63  ? 237 VAL A CA  1 
ATOM   1398 C C   . VAL A 1 237 ? 113.163 100.457 91.163  1.00 76.88  ? 237 VAL A C   1 
ATOM   1399 O O   . VAL A 1 237 ? 112.222 99.712  90.899  1.00 68.79  ? 237 VAL A O   1 
ATOM   1400 C CB  . VAL A 1 237 ? 115.072 98.961  91.994  1.00 72.38  ? 237 VAL A CB  1 
ATOM   1401 C CG1 . VAL A 1 237 ? 113.985 98.098  92.609  1.00 96.67  ? 237 VAL A CG1 1 
ATOM   1402 C CG2 . VAL A 1 237 ? 116.157 98.081  91.426  1.00 72.63  ? 237 VAL A CG2 1 
ATOM   1403 N N   . ILE A 1 238 ? 112.967 101.717 91.588  1.00 76.02  ? 238 ILE A N   1 
ATOM   1404 C CA  . ILE A 1 238 ? 111.632 102.269 91.801  1.00 67.10  ? 238 ILE A CA  1 
ATOM   1405 C C   . ILE A 1 238 ? 110.829 102.313 90.495  1.00 71.53  ? 238 ILE A C   1 
ATOM   1406 O O   . ILE A 1 238 ? 109.609 102.458 90.530  1.00 84.22  ? 238 ILE A O   1 
ATOM   1407 C CB  . ILE A 1 238 ? 111.763 103.649 92.487  1.00 69.85  ? 238 ILE A CB  1 
ATOM   1408 C CG1 . ILE A 1 238 ? 112.300 103.480 93.912  1.00 84.03  ? 238 ILE A CG1 1 
ATOM   1409 C CG2 . ILE A 1 238 ? 110.459 104.419 92.476  1.00 79.78  ? 238 ILE A CG2 1 
ATOM   1410 C CD1 . ILE A 1 238 ? 112.766 104.771 94.562  1.00 80.20  ? 238 ILE A CD1 1 
ATOM   1411 N N   . VAL A 1 239 ? 111.492 102.177 89.334  1.00 74.60  ? 239 VAL A N   1 
ATOM   1412 C CA  . VAL A 1 239 ? 110.818 102.092 88.049  1.00 77.54  ? 239 VAL A CA  1 
ATOM   1413 C C   . VAL A 1 239 ? 109.953 100.822 87.949  1.00 86.00  ? 239 VAL A C   1 
ATOM   1414 O O   . VAL A 1 239 ? 108.970 100.824 87.214  1.00 98.40  ? 239 VAL A O   1 
ATOM   1415 C CB  . VAL A 1 239 ? 111.843 102.179 86.903  1.00 82.67  ? 239 VAL A CB  1 
ATOM   1416 C CG1 . VAL A 1 239 ? 111.230 101.890 85.540  1.00 103.30 ? 239 VAL A CG1 1 
ATOM   1417 C CG2 . VAL A 1 239 ? 112.518 103.532 86.886  1.00 91.82  ? 239 VAL A CG2 1 
ATOM   1418 N N   . VAL A 1 240 ? 110.268 99.739  88.680  1.00 80.07  ? 240 VAL A N   1 
ATOM   1419 C CA  . VAL A 1 240 ? 109.552 98.479  88.501  1.00 78.94  ? 240 VAL A CA  1 
ATOM   1420 C C   . VAL A 1 240 ? 108.138 98.536  89.102  1.00 87.82  ? 240 VAL A C   1 
ATOM   1421 O O   . VAL A 1 240 ? 107.192 98.196  88.397  1.00 94.18  ? 240 VAL A O   1 
ATOM   1422 C CB  . VAL A 1 240 ? 110.356 97.265  88.996  1.00 72.33  ? 240 VAL A CB  1 
ATOM   1423 C CG1 . VAL A 1 240 ? 109.524 95.995  89.037  1.00 72.03  ? 240 VAL A CG1 1 
ATOM   1424 C CG2 . VAL A 1 240 ? 111.589 97.051  88.136  1.00 87.16  ? 240 VAL A CG2 1 
ATOM   1425 N N   . PRO A 1 241 ? 107.892 98.955  90.370  1.00 88.74  ? 241 PRO A N   1 
ATOM   1426 C CA  . PRO A 1 241 ? 106.530 99.198  90.844  1.00 83.16  ? 241 PRO A CA  1 
ATOM   1427 C C   . PRO A 1 241 ? 105.679 100.111 89.969  1.00 87.61  ? 241 PRO A C   1 
ATOM   1428 O O   . PRO A 1 241 ? 104.485 99.866  89.815  1.00 109.07 ? 241 PRO A O   1 
ATOM   1429 C CB  . PRO A 1 241 ? 106.730 99.822  92.233  1.00 70.62  ? 241 PRO A CB  1 
ATOM   1430 C CG  . PRO A 1 241 ? 107.998 99.194  92.705  1.00 85.41  ? 241 PRO A CG  1 
ATOM   1431 C CD  . PRO A 1 241 ? 108.863 99.108  91.459  1.00 94.40  ? 241 PRO A CD  1 
ATOM   1432 N N   . ALA A 1 242 ? 106.287 101.161 89.405  1.00 85.04  ? 242 ALA A N   1 
ATOM   1433 C CA  . ALA A 1 242 ? 105.593 102.091 88.532  1.00 75.40  ? 242 ALA A CA  1 
ATOM   1434 C C   . ALA A 1 242 ? 105.189 101.409 87.223  1.00 73.24  ? 242 ALA A C   1 
ATOM   1435 O O   . ALA A 1 242 ? 104.052 101.548 86.792  1.00 102.25 ? 242 ALA A O   1 
ATOM   1436 C CB  . ALA A 1 242 ? 106.451 103.317 88.302  1.00 78.68  ? 242 ALA A CB  1 
ATOM   1437 N N   . VAL A 1 243 ? 106.081 100.632 86.601  1.00 72.07  ? 243 VAL A N   1 
ATOM   1438 C CA  . VAL A 1 243 ? 105.783 99.984  85.330  1.00 76.75  ? 243 VAL A CA  1 
ATOM   1439 C C   . VAL A 1 243 ? 104.789 98.832  85.511  1.00 75.35  ? 243 VAL A C   1 
ATOM   1440 O O   . VAL A 1 243 ? 103.935 98.632  84.648  1.00 94.47  ? 243 VAL A O   1 
ATOM   1441 C CB  . VAL A 1 243 ? 107.075 99.552  84.607  1.00 83.12  ? 243 VAL A CB  1 
ATOM   1442 C CG1 . VAL A 1 243 ? 106.830 98.558  83.482  1.00 88.81  ? 243 VAL A CG1 1 
ATOM   1443 C CG2 . VAL A 1 243 ? 107.818 100.773 84.079  1.00 92.49  ? 243 VAL A CG2 1 
ATOM   1444 N N   . VAL A 1 244 ? 104.839 98.104  86.635  1.00 81.55  ? 244 VAL A N   1 
ATOM   1445 C CA  . VAL A 1 244 ? 103.874 97.039  86.913  1.00 90.56  ? 244 VAL A CA  1 
ATOM   1446 C C   . VAL A 1 244 ? 102.467 97.608  87.149  1.00 87.40  ? 244 VAL A C   1 
ATOM   1447 O O   . VAL A 1 244 ? 101.478 96.965  86.818  1.00 77.19  ? 244 VAL A O   1 
ATOM   1448 C CB  . VAL A 1 244 ? 104.333 96.157  88.087  1.00 88.84  ? 244 VAL A CB  1 
ATOM   1449 C CG1 . VAL A 1 244 ? 103.208 95.294  88.645  1.00 83.24  ? 244 VAL A CG1 1 
ATOM   1450 C CG2 . VAL A 1 244 ? 105.527 95.303  87.687  1.00 108.18 ? 244 VAL A CG2 1 
ATOM   1451 N N   . GLN A 1 245 ? 102.369 98.837  87.663  1.00 87.79  ? 245 GLN A N   1 
ATOM   1452 C CA  . GLN A 1 245 ? 101.082 99.500  87.791  1.00 81.16  ? 245 GLN A CA  1 
ATOM   1453 C C   . GLN A 1 245 ? 100.582 99.992  86.431  1.00 74.62  ? 245 GLN A C   1 
ATOM   1454 O O   . GLN A 1 245 ? 99.448  99.705  86.072  1.00 84.86  ? 245 GLN A O   1 
ATOM   1455 C CB  . GLN A 1 245 ? 101.161 100.648 88.797  1.00 69.28  ? 245 GLN A CB  1 
ATOM   1456 C CG  . GLN A 1 245 ? 99.801  101.241 89.072  1.00 70.63  ? 245 GLN A CG  1 
ATOM   1457 C CD  . GLN A 1 245 ? 99.874  102.286 90.149  1.00 79.27  ? 245 GLN A CD  1 
ATOM   1458 O OE1 . GLN A 1 245 ? 100.205 103.435 89.900  1.00 93.51  ? 245 GLN A OE1 1 
ATOM   1459 N NE2 . GLN A 1 245 ? 99.535  101.909 91.360  1.00 73.15  ? 245 GLN A NE2 1 
ATOM   1460 N N   . LEU A 1 246 ? 101.423 100.695 85.662  1.00 78.33  ? 246 LEU A N   1 
ATOM   1461 C CA  . LEU A 1 246 ? 101.055 101.233 84.353  1.00 82.66  ? 246 LEU A CA  1 
ATOM   1462 C C   . LEU A 1 246 ? 100.616 100.145 83.373  1.00 84.44  ? 246 LEU A C   1 
ATOM   1463 O O   . LEU A 1 246 ? 99.853  100.442 82.458  1.00 94.47  ? 246 LEU A O   1 
ATOM   1464 C CB  . LEU A 1 246 ? 102.250 101.984 83.753  1.00 94.80  ? 246 LEU A CB  1 
ATOM   1465 C CG  . LEU A 1 246 ? 102.492 103.396 84.272  1.00 85.99  ? 246 LEU A CG  1 
ATOM   1466 C CD1 . LEU A 1 246 ? 103.803 103.949 83.748  1.00 94.32  ? 246 LEU A CD1 1 
ATOM   1467 C CD2 . LEU A 1 246 ? 101.355 104.291 83.872  1.00 94.17  ? 246 LEU A CD2 1 
ATOM   1468 N N   . LEU A 1 247 ? 101.123 98.912  83.521  1.00 86.68  ? 247 LEU A N   1 
ATOM   1469 C CA  . LEU A 1 247 ? 100.778 97.828  82.611  1.00 105.14 ? 247 LEU A CA  1 
ATOM   1470 C C   . LEU A 1 247 ? 99.525  97.072  83.054  1.00 97.61  ? 247 LEU A C   1 
ATOM   1471 O O   . LEU A 1 247 ? 99.037  96.257  82.277  1.00 117.39 ? 247 LEU A O   1 
ATOM   1472 C CB  . LEU A 1 247 ? 101.968 96.865  82.494  1.00 122.21 ? 247 LEU A CB  1 
ATOM   1473 C CG  . LEU A 1 247 ? 103.165 97.395  81.706  1.00 131.97 ? 247 LEU A CG  1 
ATOM   1474 C CD1 . LEU A 1 247 ? 104.355 96.455  81.830  1.00 141.20 ? 247 LEU A CD1 1 
ATOM   1475 C CD2 . LEU A 1 247 ? 102.792 97.605  80.243  1.00 137.09 ? 247 LEU A CD2 1 
ATOM   1476 N N   . SER A 1 248 ? 99.007  97.313  84.271  1.00 94.75  ? 248 SER A N   1 
ATOM   1477 C CA  . SER A 1 248 ? 97.885  96.528  84.793  1.00 110.23 ? 248 SER A CA  1 
ATOM   1478 C C   . SER A 1 248 ? 96.636  97.354  85.124  1.00 109.24 ? 248 SER A C   1 
ATOM   1479 O O   . SER A 1 248 ? 95.536  96.840  84.922  1.00 124.56 ? 248 SER A O   1 
ATOM   1480 C CB  . SER A 1 248 ? 98.289  95.676  85.977  1.00 106.00 ? 248 SER A CB  1 
ATOM   1481 O OG  . SER A 1 248 ? 98.750  96.472  87.048  1.00 106.44 ? 248 SER A OG  1 
ATOM   1482 N N   . LEU A 1 249 ? 96.762  98.612  85.585  1.00 107.01 ? 249 LEU A N   1 
ATOM   1483 C CA  . LEU A 1 249 ? 95.579  99.394  85.935  1.00 91.91  ? 249 LEU A CA  1 
ATOM   1484 C C   . LEU A 1 249 ? 94.753  99.730  84.690  1.00 95.26  ? 249 LEU A C   1 
ATOM   1485 O O   . LEU A 1 249 ? 93.533  99.714  84.784  1.00 118.53 ? 249 LEU A O   1 
ATOM   1486 C CB  . LEU A 1 249 ? 95.934  100.670 86.710  1.00 82.11  ? 249 LEU A CB  1 
ATOM   1487 C CG  . LEU A 1 249 ? 96.132  100.533 88.220  1.00 95.57  ? 249 LEU A CG  1 
ATOM   1488 C CD1 . LEU A 1 249 ? 96.211  101.895 88.882  1.00 91.25  ? 249 LEU A CD1 1 
ATOM   1489 C CD2 . LEU A 1 249 ? 95.027  99.708  88.859  1.00 106.90 ? 249 LEU A CD2 1 
ATOM   1490 N N   . PRO A 1 250 ? 95.319  100.095 83.514  1.00 81.79  ? 250 PRO A N   1 
ATOM   1491 C CA  . PRO A 1 250 ? 94.492  100.458 82.364  1.00 87.04  ? 250 PRO A CA  1 
ATOM   1492 C C   . PRO A 1 250 ? 93.461  99.436  81.876  1.00 98.14  ? 250 PRO A C   1 
ATOM   1493 O O   . PRO A 1 250 ? 92.549  99.810  81.140  1.00 122.31 ? 250 PRO A O   1 
ATOM   1494 C CB  . PRO A 1 250 ? 95.529  100.732 81.265  1.00 94.62  ? 250 PRO A CB  1 
ATOM   1495 C CG  . PRO A 1 250 ? 96.735  101.196 82.024  1.00 88.97  ? 250 PRO A CG  1 
ATOM   1496 C CD  . PRO A 1 250 ? 96.746  100.314 83.253  1.00 87.91  ? 250 PRO A CD  1 
ATOM   1497 N N   . PHE A 1 251 ? 93.585  98.166  82.283  1.00 98.12  ? 251 PHE A N   1 
ATOM   1498 C CA  . PHE A 1 251 ? 92.636  97.129  81.894  1.00 110.49 ? 251 PHE A CA  1 
ATOM   1499 C C   . PHE A 1 251 ? 91.448  97.017  82.854  1.00 98.76  ? 251 PHE A C   1 
ATOM   1500 O O   . PHE A 1 251 ? 90.470  96.353  82.523  1.00 122.59 ? 251 PHE A O   1 
ATOM   1501 C CB  . PHE A 1 251 ? 93.347  95.779  81.779  1.00 119.17 ? 251 PHE A CB  1 
ATOM   1502 C CG  . PHE A 1 251 ? 94.352  95.727  80.659  1.00 128.54 ? 251 PHE A CG  1 
ATOM   1503 C CD1 . PHE A 1 251 ? 93.934  95.649  79.341  1.00 143.04 ? 251 PHE A CD1 1 
ATOM   1504 C CD2 . PHE A 1 251 ? 95.708  95.809  80.920  1.00 133.96 ? 251 PHE A CD2 1 
ATOM   1505 C CE1 . PHE A 1 251 ? 94.854  95.611  78.307  1.00 150.78 ? 251 PHE A CE1 1 
ATOM   1506 C CE2 . PHE A 1 251 ? 96.628  95.778  79.886  1.00 153.99 ? 251 PHE A CE2 1 
ATOM   1507 C CZ  . PHE A 1 251 ? 96.199  95.679  78.582  1.00 163.08 ? 251 PHE A CZ  1 
ATOM   1508 N N   . LEU A 1 252 ? 91.523  97.653  84.030  1.00 90.76  ? 252 LEU A N   1 
ATOM   1509 C CA  . LEU A 1 252 ? 90.460  97.595  85.025  1.00 99.65  ? 252 LEU A CA  1 
ATOM   1510 C C   . LEU A 1 252 ? 89.481  98.762  84.852  1.00 120.22 ? 252 LEU A C   1 
ATOM   1511 O O   . LEU A 1 252 ? 89.838  99.826  84.336  1.00 128.76 ? 252 LEU A O   1 
ATOM   1512 C CB  . LEU A 1 252 ? 91.091  97.657  86.418  1.00 98.90  ? 252 LEU A CB  1 
ATOM   1513 C CG  . LEU A 1 252 ? 92.123  96.583  86.722  1.00 120.54 ? 252 LEU A CG  1 
ATOM   1514 C CD1 . LEU A 1 252 ? 92.649  96.759  88.132  1.00 125.15 ? 252 LEU A CD1 1 
ATOM   1515 C CD2 . LEU A 1 252 ? 91.527  95.197  86.518  1.00 131.55 ? 252 LEU A CD2 1 
ATOM   1516 N N   . PRO A 1 253 ? 88.215  98.620  85.319  1.00 107.58 ? 253 PRO A N   1 
ATOM   1517 C CA  . PRO A 1 253 ? 87.271  99.736  85.332  1.00 101.96 ? 253 PRO A CA  1 
ATOM   1518 C C   . PRO A 1 253 ? 87.678  100.887 86.251  1.00 102.66 ? 253 PRO A C   1 
ATOM   1519 O O   . PRO A 1 253 ? 88.413  100.689 87.219  1.00 95.29  ? 253 PRO A O   1 
ATOM   1520 C CB  . PRO A 1 253 ? 85.962  99.115  85.830  1.00 104.41 ? 253 PRO A CB  1 
ATOM   1521 C CG  . PRO A 1 253 ? 86.123  97.626  85.595  1.00 112.98 ? 253 PRO A CG  1 
ATOM   1522 C CD  . PRO A 1 253 ? 87.601  97.362  85.765  1.00 105.32 ? 253 PRO A CD  1 
ATOM   1523 N N   . ASP A 1 254 ? 87.221  102.099 85.894  1.00 104.27 ? 254 ASP A N   1 
ATOM   1524 C CA  . ASP A 1 254 ? 87.303  103.258 86.771  1.00 103.73 ? 254 ASP A CA  1 
ATOM   1525 C C   . ASP A 1 254 ? 86.339  103.066 87.943  1.00 92.47  ? 254 ASP A C   1 
ATOM   1526 O O   . ASP A 1 254 ? 85.483  102.183 87.914  1.00 109.47 ? 254 ASP A O   1 
ATOM   1527 C CB  . ASP A 1 254 ? 87.033  104.537 85.969  1.00 110.02 ? 254 ASP A CB  1 
ATOM   1528 C CG  . ASP A 1 254 ? 87.483  105.845 86.615  1.00 125.01 ? 254 ASP A CG  1 
ATOM   1529 O OD1 . ASP A 1 254 ? 88.069  105.817 87.730  1.00 113.86 ? 254 ASP A OD1 1 
ATOM   1530 O OD2 . ASP A 1 254 ? 87.229  106.903 85.998  1.00 137.89 ? 254 ASP A OD2 1 
ATOM   1531 N N   . SER A 1 255 ? 86.466  103.890 88.989  1.00 89.79  ? 255 SER A N   1 
ATOM   1532 C CA  . SER A 1 255 ? 85.610  103.787 90.165  1.00 81.69  ? 255 SER A CA  1 
ATOM   1533 C C   . SER A 1 255 ? 84.134  103.960 89.797  1.00 81.46  ? 255 SER A C   1 
ATOM   1534 O O   . SER A 1 255 ? 83.754  104.920 89.126  1.00 83.53  ? 255 SER A O   1 
ATOM   1535 C CB  . SER A 1 255 ? 86.013  104.789 91.196  1.00 81.49  ? 255 SER A CB  1 
ATOM   1536 O OG  . SER A 1 255 ? 84.992  104.918 92.155  1.00 84.63  ? 255 SER A OG  1 
ATOM   1537 N N   . PRO A 1 256 ? 83.232  103.057 90.251  1.00 95.17  ? 256 PRO A N   1 
ATOM   1538 C CA  . PRO A 1 256 ? 81.832  103.109 89.832  1.00 89.52  ? 256 PRO A CA  1 
ATOM   1539 C C   . PRO A 1 256 ? 81.013  104.240 90.442  1.00 80.52  ? 256 PRO A C   1 
ATOM   1540 O O   . PRO A 1 256 ? 79.866  104.415 90.049  1.00 90.89  ? 256 PRO A O   1 
ATOM   1541 C CB  . PRO A 1 256 ? 81.319  101.743 90.305  1.00 84.51  ? 256 PRO A CB  1 
ATOM   1542 C CG  . PRO A 1 256 ? 82.120  101.465 91.536  1.00 101.22 ? 256 PRO A CG  1 
ATOM   1543 C CD  . PRO A 1 256 ? 83.506  101.931 91.163  1.00 98.95  ? 256 PRO A CD  1 
ATOM   1544 N N   . ARG A 1 257 ? 81.581  104.977 91.410  1.00 79.22  ? 257 ARG A N   1 
ATOM   1545 C CA  . ARG A 1 257 ? 80.939  106.172 91.955  1.00 85.78  ? 257 ARG A CA  1 
ATOM   1546 C C   . ARG A 1 257 ? 81.276  107.375 91.075  1.00 88.10  ? 257 ARG A C   1 
ATOM   1547 O O   . ARG A 1 257 ? 80.372  108.078 90.626  1.00 81.37  ? 257 ARG A O   1 
ATOM   1548 C CB  . ARG A 1 257 ? 81.347  106.396 93.418  1.00 88.95  ? 257 ARG A CB  1 
ATOM   1549 C CG  . ARG A 1 257 ? 81.110  107.796 93.966  1.00 93.43  ? 257 ARG A CG  1 
ATOM   1550 C CD  . ARG A 1 257 ? 81.352  107.793 95.469  1.00 111.24 ? 257 ARG A CD  1 
ATOM   1551 N NE  . ARG A 1 257 ? 80.802  108.954 96.156  1.00 136.40 ? 257 ARG A NE  1 
ATOM   1552 C CZ  . ARG A 1 257 ? 81.412  110.130 96.293  1.00 158.95 ? 257 ARG A CZ  1 
ATOM   1553 N NH1 . ARG A 1 257 ? 80.795  111.131 96.902  1.00 168.30 ? 257 ARG A NH1 1 
ATOM   1554 N NH2 . ARG A 1 257 ? 82.634  110.313 95.820  1.00 162.95 ? 257 ARG A NH2 1 
ATOM   1555 N N   . TYR A 1 258 ? 82.578  107.573 90.815  1.00 86.62  ? 258 TYR A N   1 
ATOM   1556 C CA  . TYR A 1 258 ? 83.058  108.610 89.919  1.00 84.37  ? 258 TYR A CA  1 
ATOM   1557 C C   . TYR A 1 258 ? 82.329  108.524 88.574  1.00 72.81  ? 258 TYR A C   1 
ATOM   1558 O O   . TYR A 1 258 ? 81.805  109.521 88.093  1.00 98.71  ? 258 TYR A O   1 
ATOM   1559 C CB  . TYR A 1 258 ? 84.583  108.543 89.744  1.00 93.48  ? 258 TYR A CB  1 
ATOM   1560 C CG  . TYR A 1 258 ? 85.094  109.631 88.807  1.00 96.13  ? 258 TYR A CG  1 
ATOM   1561 C CD1 . TYR A 1 258 ? 85.401  110.904 89.276  1.00 95.55  ? 258 TYR A CD1 1 
ATOM   1562 C CD2 . TYR A 1 258 ? 85.181  109.413 87.438  1.00 88.50  ? 258 TYR A CD2 1 
ATOM   1563 C CE1 . TYR A 1 258 ? 85.808  111.911 88.419  1.00 98.31  ? 258 TYR A CE1 1 
ATOM   1564 C CE2 . TYR A 1 258 ? 85.602  110.408 86.573  1.00 90.96  ? 258 TYR A CE2 1 
ATOM   1565 C CZ  . TYR A 1 258 ? 85.910  111.662 87.064  1.00 103.56 ? 258 TYR A CZ  1 
ATOM   1566 O OH  . TYR A 1 258 ? 86.300  112.649 86.198  1.00 129.64 ? 258 TYR A OH  1 
ATOM   1567 N N   . LEU A 1 259 ? 82.233  107.338 87.981  1.00 72.73  ? 259 LEU A N   1 
ATOM   1568 C CA  . LEU A 1 259 ? 81.522  107.184 86.720  1.00 82.85  ? 259 LEU A CA  1 
ATOM   1569 C C   . LEU A 1 259 ? 80.068  107.649 86.825  1.00 87.05  ? 259 LEU A C   1 
ATOM   1570 O O   . LEU A 1 259 ? 79.522  108.143 85.847  1.00 101.14 ? 259 LEU A O   1 
ATOM   1571 C CB  . LEU A 1 259 ? 81.567  105.717 86.279  1.00 97.33  ? 259 LEU A CB  1 
ATOM   1572 C CG  . LEU A 1 259 ? 82.917  105.222 85.775  1.00 113.70 ? 259 LEU A CG  1 
ATOM   1573 C CD1 . LEU A 1 259 ? 82.932  103.702 85.667  1.00 119.36 ? 259 LEU A CD1 1 
ATOM   1574 C CD2 . LEU A 1 259 ? 83.255  105.864 84.436  1.00 117.17 ? 259 LEU A CD2 1 
ATOM   1575 N N   . LEU A 1 260 ? 79.429  107.445 87.986  1.00 86.44  ? 260 LEU A N   1 
ATOM   1576 C CA  . LEU A 1 260 ? 78.011  107.713 88.170  1.00 89.35  ? 260 LEU A CA  1 
ATOM   1577 C C   . LEU A 1 260 ? 77.753  109.174 88.555  1.00 90.93  ? 260 LEU A C   1 
ATOM   1578 O O   . LEU A 1 260 ? 76.899  109.823 87.952  1.00 105.04 ? 260 LEU A O   1 
ATOM   1579 C CB  . LEU A 1 260 ? 77.506  106.751 89.252  1.00 92.83  ? 260 LEU A CB  1 
ATOM   1580 C CG  . LEU A 1 260 ? 76.011  106.759 89.546  1.00 93.29  ? 260 LEU A CG  1 
ATOM   1581 C CD1 . LEU A 1 260 ? 75.176  106.448 88.305  1.00 84.01  ? 260 LEU A CD1 1 
ATOM   1582 C CD2 . LEU A 1 260 ? 75.730  105.761 90.652  1.00 103.01 ? 260 LEU A CD2 1 
ATOM   1583 N N   . LEU A 1 261 ? 78.471  109.688 89.562  1.00 92.00  ? 261 LEU A N   1 
ATOM   1584 C CA  . LEU A 1 261 ? 78.207  111.008 90.129  1.00 96.48  ? 261 LEU A CA  1 
ATOM   1585 C C   . LEU A 1 261 ? 78.902  112.121 89.343  1.00 107.32 ? 261 LEU A C   1 
ATOM   1586 O O   . LEU A 1 261 ? 78.287  113.150 89.068  1.00 122.66 ? 261 LEU A O   1 
ATOM   1587 C CB  . LEU A 1 261 ? 78.697  111.042 91.582  1.00 98.41  ? 261 LEU A CB  1 
ATOM   1588 C CG  . LEU A 1 261 ? 78.031  110.059 92.545  1.00 107.40 ? 261 LEU A CG  1 
ATOM   1589 C CD1 . LEU A 1 261 ? 78.525  110.286 93.962  1.00 102.87 ? 261 LEU A CD1 1 
ATOM   1590 C CD2 . LEU A 1 261 ? 76.513  110.168 92.484  1.00 109.93 ? 261 LEU A CD2 1 
ATOM   1591 N N   . GLU A 1 262 ? 80.192  111.920 89.029  1.00 123.54 ? 262 GLU A N   1 
ATOM   1592 C CA  . GLU A 1 262 ? 81.080  112.977 88.556  1.00 116.56 ? 262 GLU A CA  1 
ATOM   1593 C C   . GLU A 1 262 ? 81.223  112.939 87.027  1.00 113.01 ? 262 GLU A C   1 
ATOM   1594 O O   . GLU A 1 262 ? 81.441  113.985 86.419  1.00 127.29 ? 262 GLU A O   1 
ATOM   1595 C CB  . GLU A 1 262 ? 82.423  112.875 89.292  1.00 117.55 ? 262 GLU A CB  1 
ATOM   1596 C CG  . GLU A 1 262 ? 82.282  112.807 90.819  1.00 154.93 ? 262 GLU A CG  1 
ATOM   1597 C CD  . GLU A 1 262 ? 83.560  112.977 91.635  1.00 184.68 ? 262 GLU A CD  1 
ATOM   1598 O OE1 . GLU A 1 262 ? 84.230  114.014 91.460  1.00 199.75 ? 262 GLU A OE1 1 
ATOM   1599 O OE2 . GLU A 1 262 ? 83.880  112.084 92.462  1.00 194.54 ? 262 GLU A OE2 1 
ATOM   1600 N N   . LYS A 1 263 ? 81.071  111.755 86.404  1.00 114.40 ? 263 LYS A N   1 
ATOM   1601 C CA  . LYS A 1 263 ? 81.138  111.600 84.953  1.00 120.31 ? 263 LYS A CA  1 
ATOM   1602 C C   . LYS A 1 263 ? 79.756  111.496 84.292  1.00 116.97 ? 263 LYS A C   1 
ATOM   1603 O O   . LYS A 1 263 ? 79.674  111.566 83.066  1.00 98.57  ? 263 LYS A O   1 
ATOM   1604 C CB  . LYS A 1 263 ? 81.987  110.380 84.581  1.00 130.86 ? 263 LYS A CB  1 
ATOM   1605 C CG  . LYS A 1 263 ? 83.228  110.691 83.752  1.00 143.56 ? 263 LYS A CG  1 
ATOM   1606 C CD  . LYS A 1 263 ? 82.897  111.175 82.360  1.00 165.48 ? 263 LYS A CD  1 
ATOM   1607 C CE  . LYS A 1 263 ? 84.118  111.325 81.477  1.00 183.73 ? 263 LYS A CE  1 
ATOM   1608 N NZ  . LYS A 1 263 ? 83.746  111.740 80.103  1.00 196.77 ? 263 LYS A NZ  1 
ATOM   1609 N N   . HIS A 1 264 ? 78.693  111.319 85.098  1.00 129.02 ? 264 HIS A N   1 
ATOM   1610 C CA  . HIS A 1 264 ? 77.291  111.265 84.676  1.00 133.31 ? 264 HIS A CA  1 
ATOM   1611 C C   . HIS A 1 264 ? 77.000  110.145 83.671  1.00 132.09 ? 264 HIS A C   1 
ATOM   1612 O O   . HIS A 1 264 ? 76.070  110.264 82.871  1.00 149.19 ? 264 HIS A O   1 
ATOM   1613 C CB  . HIS A 1 264 ? 76.810  112.632 84.168  1.00 162.82 ? 264 HIS A CB  1 
ATOM   1614 C CG  . HIS A 1 264 ? 76.916  113.740 85.171  1.00 199.61 ? 264 HIS A CG  1 
ATOM   1615 N ND1 . HIS A 1 264 ? 76.058  113.939 86.233  1.00 214.54 ? 264 HIS A ND1 1 
ATOM   1616 C CD2 . HIS A 1 264 ? 77.810  114.732 85.223  1.00 212.14 ? 264 HIS A CD2 1 
ATOM   1617 C CE1 . HIS A 1 264 ? 76.440  115.016 86.903  1.00 222.85 ? 264 HIS A CE1 1 
ATOM   1618 N NE2 . HIS A 1 264 ? 77.502  115.514 86.305  1.00 224.48 ? 264 HIS A NE2 1 
ATOM   1619 N N   . ASN A 1 265 ? 77.732  109.024 83.766  1.00 146.60 ? 265 ASN A N   1 
ATOM   1620 C CA  . ASN A 1 265 ? 77.632  107.938 82.798  1.00 144.92 ? 265 ASN A CA  1 
ATOM   1621 C C   . ASN A 1 265 ? 77.160  106.661 83.498  1.00 135.43 ? 265 ASN A C   1 
ATOM   1622 O O   . ASN A 1 265 ? 77.975  105.819 83.883  1.00 135.92 ? 265 ASN A O   1 
ATOM   1623 C CB  . ASN A 1 265 ? 78.970  107.734 82.077  1.00 151.57 ? 265 ASN A CB  1 
ATOM   1624 C CG  . ASN A 1 265 ? 78.853  106.933 80.796  1.00 165.82 ? 265 ASN A CG  1 
ATOM   1625 O OD1 . ASN A 1 265 ? 78.120  105.948 80.737  1.00 156.51 ? 265 ASN A OD1 1 
ATOM   1626 N ND2 . ASN A 1 265 ? 79.569  107.345 79.762  1.00 185.39 ? 265 ASN A ND2 1 
ATOM   1627 N N   . GLU A 1 266 ? 75.832  106.489 83.594  1.00 136.60 ? 266 GLU A N   1 
ATOM   1628 C CA  . GLU A 1 266 ? 75.233  105.447 84.417  1.00 146.00 ? 266 GLU A CA  1 
ATOM   1629 C C   . GLU A 1 266 ? 75.508  104.055 83.842  1.00 141.14 ? 266 GLU A C   1 
ATOM   1630 O O   . GLU A 1 266 ? 75.690  103.103 84.601  1.00 145.38 ? 266 GLU A O   1 
ATOM   1631 C CB  . GLU A 1 266 ? 73.735  105.717 84.584  1.00 169.41 ? 266 GLU A CB  1 
ATOM   1632 C CG  . GLU A 1 266 ? 73.025  104.726 85.495  1.00 193.60 ? 266 GLU A CG  1 
ATOM   1633 C CD  . GLU A 1 266 ? 71.609  105.112 85.900  1.00 216.99 ? 266 GLU A CD  1 
ATOM   1634 O OE1 . GLU A 1 266 ? 71.430  106.231 86.430  1.00 207.96 ? 266 GLU A OE1 1 
ATOM   1635 O OE2 . GLU A 1 266 ? 70.686  104.288 85.700  1.00 228.70 ? 266 GLU A OE2 1 
ATOM   1636 N N   . ALA A 1 267 ? 75.572  103.936 82.507  1.00 138.79 ? 267 ALA A N   1 
ATOM   1637 C CA  . ALA A 1 267 ? 75.786  102.653 81.848  1.00 131.73 ? 267 ALA A CA  1 
ATOM   1638 C C   . ALA A 1 267 ? 77.171  102.083 82.171  1.00 106.19 ? 267 ALA A C   1 
ATOM   1639 O O   . ALA A 1 267 ? 77.308  100.878 82.370  1.00 113.01 ? 267 ALA A O   1 
ATOM   1640 C CB  . ALA A 1 267 ? 75.577  102.805 80.356  1.00 143.92 ? 267 ALA A CB  1 
ATOM   1641 N N   . ARG A 1 268 ? 78.197  102.945 82.232  1.00 100.54 ? 268 ARG A N   1 
ATOM   1642 C CA  . ARG A 1 268 ? 79.541  102.533 82.607  1.00 106.55 ? 268 ARG A CA  1 
ATOM   1643 C C   . ARG A 1 268 ? 79.618  102.210 84.098  1.00 99.48  ? 268 ARG A C   1 
ATOM   1644 O O   . ARG A 1 268 ? 80.315  101.270 84.478  1.00 107.86 ? 268 ARG A O   1 
ATOM   1645 C CB  . ARG A 1 268 ? 80.575  103.609 82.262  1.00 126.31 ? 268 ARG A CB  1 
ATOM   1646 C CG  . ARG A 1 268 ? 80.875  103.747 80.778  1.00 142.55 ? 268 ARG A CG  1 
ATOM   1647 C CD  . ARG A 1 268 ? 82.017  104.720 80.544  1.00 163.45 ? 268 ARG A CD  1 
ATOM   1648 N NE  . ARG A 1 268 ? 82.331  104.888 79.132  1.00 212.57 ? 268 ARG A NE  1 
ATOM   1649 C CZ  . ARG A 1 268 ? 83.297  105.669 78.656  1.00 258.81 ? 268 ARG A CZ  1 
ATOM   1650 N NH1 . ARG A 1 268 ? 83.491  105.757 77.351  1.00 270.95 ? 268 ARG A NH1 1 
ATOM   1651 N NH2 . ARG A 1 268 ? 84.065  106.364 79.481  1.00 266.48 ? 268 ARG A NH2 1 
ATOM   1652 N N   . ALA A 1 269 ? 78.912  102.979 84.937  1.00 89.06  ? 269 ALA A N   1 
ATOM   1653 C CA  . ALA A 1 269 ? 78.884  102.737 86.374  1.00 87.54  ? 269 ALA A CA  1 
ATOM   1654 C C   . ALA A 1 269 ? 78.274  101.367 86.679  1.00 93.14  ? 269 ALA A C   1 
ATOM   1655 O O   . ALA A 1 269 ? 78.795  100.633 87.512  1.00 97.50  ? 269 ALA A O   1 
ATOM   1656 C CB  . ALA A 1 269 ? 78.138  103.849 87.073  1.00 100.07 ? 269 ALA A CB  1 
ATOM   1657 N N   . VAL A 1 270 ? 77.178  101.006 85.998  1.00 94.65  ? 270 VAL A N   1 
ATOM   1658 C CA  . VAL A 1 270 ? 76.591  99.682  86.129  1.00 90.23  ? 270 VAL A CA  1 
ATOM   1659 C C   . VAL A 1 270 ? 77.615  98.617  85.736  1.00 105.07 ? 270 VAL A C   1 
ATOM   1660 O O   . VAL A 1 270 ? 77.791  97.652  86.475  1.00 118.55 ? 270 VAL A O   1 
ATOM   1661 C CB  . VAL A 1 270 ? 75.278  99.559  85.333  1.00 94.88  ? 270 VAL A CB  1 
ATOM   1662 C CG1 . VAL A 1 270 ? 74.848  98.119  85.118  1.00 104.60 ? 270 VAL A CG1 1 
ATOM   1663 C CG2 . VAL A 1 270 ? 74.159  100.330 86.004  1.00 115.53 ? 270 VAL A CG2 1 
ATOM   1664 N N   . LYS A 1 271 ? 78.313  98.794  84.604  1.00 110.47 ? 271 LYS A N   1 
ATOM   1665 C CA  . LYS A 1 271 ? 79.261  97.801  84.109  1.00 116.64 ? 271 LYS A CA  1 
ATOM   1666 C C   . LYS A 1 271 ? 80.468  97.644  85.046  1.00 100.05 ? 271 LYS A C   1 
ATOM   1667 O O   . LYS A 1 271 ? 81.028  96.552  85.159  1.00 94.12  ? 271 LYS A O   1 
ATOM   1668 C CB  . LYS A 1 271 ? 79.693  98.157  82.684  1.00 133.87 ? 271 LYS A CB  1 
ATOM   1669 C CG  . LYS A 1 271 ? 80.407  97.041  81.937  1.00 173.71 ? 271 LYS A CG  1 
ATOM   1670 C CD  . LYS A 1 271 ? 80.572  97.310  80.457  1.00 205.36 ? 271 LYS A CD  1 
ATOM   1671 C CE  . LYS A 1 271 ? 81.166  96.132  79.713  1.00 222.55 ? 271 LYS A CE  1 
ATOM   1672 N NZ  . LYS A 1 271 ? 81.229  96.383  78.254  1.00 230.00 ? 271 LYS A NZ  1 
ATOM   1673 N N   . ALA A 1 272 ? 80.861  98.728  85.731  1.00 83.50  ? 272 ALA A N   1 
ATOM   1674 C CA  . ALA A 1 272 ? 81.943  98.688  86.701  1.00 76.25  ? 272 ALA A CA  1 
ATOM   1675 C C   . ALA A 1 272 ? 81.506  97.982  87.990  1.00 83.39  ? 272 ALA A C   1 
ATOM   1676 O O   . ALA A 1 272 ? 82.248  97.152  88.504  1.00 91.35  ? 272 ALA A O   1 
ATOM   1677 C CB  . ALA A 1 272 ? 82.442  100.092 86.956  1.00 82.43  ? 272 ALA A CB  1 
ATOM   1678 N N   . PHE A 1 273 ? 80.301  98.273  88.509  1.00 92.24  ? 273 PHE A N   1 
ATOM   1679 C CA  . PHE A 1 273 ? 79.744  97.530  89.634  1.00 90.59  ? 273 PHE A CA  1 
ATOM   1680 C C   . PHE A 1 273 ? 79.630  96.039  89.295  1.00 96.20  ? 273 PHE A C   1 
ATOM   1681 O O   . PHE A 1 273 ? 80.007  95.200  90.108  1.00 96.16  ? 273 PHE A O   1 
ATOM   1682 C CB  . PHE A 1 273 ? 78.356  98.045  90.029  1.00 93.64  ? 273 PHE A CB  1 
ATOM   1683 C CG  . PHE A 1 273 ? 78.304  99.277  90.894  1.00 87.81  ? 273 PHE A CG  1 
ATOM   1684 C CD1 . PHE A 1 273 ? 78.950  99.315  92.112  1.00 91.56  ? 273 PHE A CD1 1 
ATOM   1685 C CD2 . PHE A 1 273 ? 77.551  100.374 90.515  1.00 86.02  ? 273 PHE A CD2 1 
ATOM   1686 C CE1 . PHE A 1 273 ? 78.876  100.446 92.916  1.00 98.18  ? 273 PHE A CE1 1 
ATOM   1687 C CE2 . PHE A 1 273 ? 77.480  101.500 91.317  1.00 88.85  ? 273 PHE A CE2 1 
ATOM   1688 C CZ  . PHE A 1 273 ? 78.144  101.534 92.517  1.00 90.38  ? 273 PHE A CZ  1 
ATOM   1689 N N   . GLN A 1 274 ? 79.113  95.704  88.103  1.00 92.54  ? 274 GLN A N   1 
ATOM   1690 C CA  . GLN A 1 274 ? 78.953  94.319  87.685  1.00 99.95  ? 274 GLN A CA  1 
ATOM   1691 C C   . GLN A 1 274 ? 80.301  93.600  87.602  1.00 98.24  ? 274 GLN A C   1 
ATOM   1692 O O   . GLN A 1 274 ? 80.363  92.396  87.839  1.00 124.87 ? 274 GLN A O   1 
ATOM   1693 C CB  . GLN A 1 274 ? 78.213  94.243  86.346  1.00 114.68 ? 274 GLN A CB  1 
ATOM   1694 C CG  . GLN A 1 274 ? 76.719  94.513  86.450  1.00 110.90 ? 274 GLN A CG  1 
ATOM   1695 C CD  . GLN A 1 274 ? 76.016  94.427  85.116  1.00 129.33 ? 274 GLN A CD  1 
ATOM   1696 O OE1 . GLN A 1 274 ? 76.613  94.603  84.057  1.00 145.22 ? 274 GLN A OE1 1 
ATOM   1697 N NE2 . GLN A 1 274 ? 74.718  94.176  85.153  1.00 144.21 ? 274 GLN A NE2 1 
ATOM   1698 N N   . THR A 1 275 ? 81.377  94.319  87.251  1.00 92.97  ? 275 THR A N   1 
ATOM   1699 C CA  . THR A 1 275 ? 82.712  93.738  87.129  1.00 89.45  ? 275 THR A CA  1 
ATOM   1700 C C   . THR A 1 275 ? 83.362  93.526  88.501  1.00 82.73  ? 275 THR A C   1 
ATOM   1701 O O   . THR A 1 275 ? 83.883  92.446  88.766  1.00 106.65 ? 275 THR A O   1 
ATOM   1702 C CB  . THR A 1 275 ? 83.605  94.597  86.228  1.00 102.19 ? 275 THR A CB  1 
ATOM   1703 O OG1 . THR A 1 275 ? 83.028  94.602  84.919  1.00 119.42 ? 275 THR A OG1 1 
ATOM   1704 C CG2 . THR A 1 275 ? 85.034  94.104  86.154  1.00 110.48 ? 275 THR A CG2 1 
ATOM   1705 N N   . PHE A 1 276 ? 83.338  94.543  89.369  1.00 75.61  ? 276 PHE A N   1 
ATOM   1706 C CA  . PHE A 1 276 ? 83.997  94.475  90.660  1.00 81.31  ? 276 PHE A CA  1 
ATOM   1707 C C   . PHE A 1 276 ? 83.238  93.591  91.658  1.00 86.08  ? 276 PHE A C   1 
ATOM   1708 O O   . PHE A 1 276 ? 83.867  92.854  92.412  1.00 104.94 ? 276 PHE A O   1 
ATOM   1709 C CB  . PHE A 1 276 ? 84.221  95.879  91.228  1.00 83.20  ? 276 PHE A CB  1 
ATOM   1710 C CG  . PHE A 1 276 ? 85.349  96.655  90.603  1.00 88.35  ? 276 PHE A CG  1 
ATOM   1711 C CD1 . PHE A 1 276 ? 86.634  96.151  90.581  1.00 93.82  ? 276 PHE A CD1 1 
ATOM   1712 C CD2 . PHE A 1 276 ? 85.140  97.921  90.081  1.00 112.90 ? 276 PHE A CD2 1 
ATOM   1713 C CE1 . PHE A 1 276 ? 87.678  96.889  90.037  1.00 91.51  ? 276 PHE A CE1 1 
ATOM   1714 C CE2 . PHE A 1 276 ? 86.180  98.654  89.531  1.00 105.12 ? 276 PHE A CE2 1 
ATOM   1715 C CZ  . PHE A 1 276 ? 87.450  98.132  89.505  1.00 96.26  ? 276 PHE A CZ  1 
ATOM   1716 N N   . LEU A 1 277 ? 81.902  93.651  91.698  1.00 88.57  ? 277 LEU A N   1 
ATOM   1717 C CA  . LEU A 1 277 ? 81.144  92.881  92.681  1.00 99.44  ? 277 LEU A CA  1 
ATOM   1718 C C   . LEU A 1 277 ? 80.887  91.449  92.197  1.00 109.71 ? 277 LEU A C   1 
ATOM   1719 O O   . LEU A 1 277 ? 80.640  90.565  93.017  1.00 105.92 ? 277 LEU A O   1 
ATOM   1720 C CB  . LEU A 1 277 ? 79.820  93.593  92.991  1.00 96.08  ? 277 LEU A CB  1 
ATOM   1721 C CG  . LEU A 1 277 ? 79.950  95.008  93.551  1.00 99.23  ? 277 LEU A CG  1 
ATOM   1722 C CD1 . LEU A 1 277 ? 78.587  95.570  93.901  1.00 87.98  ? 277 LEU A CD1 1 
ATOM   1723 C CD2 . LEU A 1 277 ? 80.891  95.051  94.759  1.00 104.21 ? 277 LEU A CD2 1 
ATOM   1724 N N   . GLY A 1 278 ? 80.930  91.222  90.877  1.00 108.66 ? 278 GLY A N   1 
ATOM   1725 C CA  . GLY A 1 278 ? 80.818  89.890  90.299  1.00 122.15 ? 278 GLY A CA  1 
ATOM   1726 C C   . GLY A 1 278 ? 79.383  89.356  90.275  1.00 139.99 ? 278 GLY A C   1 
ATOM   1727 O O   . GLY A 1 278 ? 79.176  88.147  90.393  1.00 161.07 ? 278 GLY A O   1 
ATOM   1728 N N   . LYS A 1 279 ? 78.402  90.259  90.095  1.00 132.60 ? 279 LYS A N   1 
ATOM   1729 C CA  . LYS A 1 279 ? 76.989  89.899  90.052  1.00 139.36 ? 279 LYS A CA  1 
ATOM   1730 C C   . LYS A 1 279 ? 76.247  90.763  89.025  1.00 150.82 ? 279 LYS A C   1 
ATOM   1731 O O   . LYS A 1 279 ? 76.722  91.830  88.651  1.00 148.66 ? 279 LYS A O   1 
ATOM   1732 C CB  . LYS A 1 279 ? 76.361  90.033  91.446  1.00 139.59 ? 279 LYS A CB  1 
ATOM   1733 C CG  . LYS A 1 279 ? 76.372  91.428  92.055  1.00 133.24 ? 279 LYS A CG  1 
ATOM   1734 C CD  . LYS A 1 279 ? 75.721  91.489  93.418  1.00 148.54 ? 279 LYS A CD  1 
ATOM   1735 C CE  . LYS A 1 279 ? 75.639  92.896  93.974  1.00 168.95 ? 279 LYS A CE  1 
ATOM   1736 N NZ  . LYS A 1 279 ? 74.911  92.947  95.265  1.00 172.62 ? 279 LYS A NZ  1 
ATOM   1737 N N   . ALA A 1 280 ? 75.054  90.311  88.608  1.00 161.08 ? 280 ALA A N   1 
ATOM   1738 C CA  . ALA A 1 280 ? 74.306  90.947  87.529  1.00 167.52 ? 280 ALA A CA  1 
ATOM   1739 C C   . ALA A 1 280 ? 73.415  92.079  88.051  1.00 169.13 ? 280 ALA A C   1 
ATOM   1740 O O   . ALA A 1 280 ? 73.419  93.170  87.485  1.00 169.09 ? 280 ALA A O   1 
ATOM   1741 C CB  . ALA A 1 280 ? 73.495  89.909  86.784  1.00 181.37 ? 280 ALA A CB  1 
ATOM   1742 N N   . ASP A 1 281 ? 72.632  91.819  89.109  1.00 177.42 ? 281 ASP A N   1 
ATOM   1743 C CA  . ASP A 1 281 ? 71.639  92.774  89.588  1.00 181.96 ? 281 ASP A CA  1 
ATOM   1744 C C   . ASP A 1 281 ? 72.271  93.724  90.607  1.00 141.37 ? 281 ASP A C   1 
ATOM   1745 O O   . ASP A 1 281 ? 72.101  93.547  91.816  1.00 141.88 ? 281 ASP A O   1 
ATOM   1746 C CB  . ASP A 1 281 ? 70.421  92.049  90.173  1.00 219.74 ? 281 ASP A CB  1 
ATOM   1747 C CG  . ASP A 1 281 ? 69.263  92.962  90.551  1.00 253.83 ? 281 ASP A CG  1 
ATOM   1748 O OD1 . ASP A 1 281 ? 69.343  94.175  90.263  1.00 261.82 ? 281 ASP A OD1 1 
ATOM   1749 O OD2 . ASP A 1 281 ? 68.288  92.450  91.138  1.00 276.46 ? 281 ASP A OD2 1 
ATOM   1750 N N   . VAL A 1 282 ? 72.945  94.770  90.104  1.00 103.14 ? 282 VAL A N   1 
ATOM   1751 C CA  . VAL A 1 282 ? 73.622  95.743  90.953  1.00 103.67 ? 282 VAL A CA  1 
ATOM   1752 C C   . VAL A 1 282 ? 72.713  96.945  91.252  1.00 120.08 ? 282 VAL A C   1 
ATOM   1753 O O   . VAL A 1 282 ? 73.205  97.984  91.701  1.00 122.95 ? 282 VAL A O   1 
ATOM   1754 C CB  . VAL A 1 282 ? 74.956  96.201  90.326  1.00 100.64 ? 282 VAL A CB  1 
ATOM   1755 C CG1 . VAL A 1 282 ? 75.953  95.065  90.241  1.00 96.76  ? 282 VAL A CG1 1 
ATOM   1756 C CG2 . VAL A 1 282 ? 74.771  96.833  88.954  1.00 122.46 ? 282 VAL A CG2 1 
ATOM   1757 N N   . SER A 1 283 ? 71.388  96.794  91.083  1.00 124.22 ? 283 SER A N   1 
ATOM   1758 C CA  . SER A 1 283 ? 70.441  97.900  91.170  1.00 128.15 ? 283 SER A CA  1 
ATOM   1759 C C   . SER A 1 283 ? 70.532  98.623  92.515  1.00 125.43 ? 283 SER A C   1 
ATOM   1760 O O   . SER A 1 283 ? 70.437  99.855  92.568  1.00 145.96 ? 283 SER A O   1 
ATOM   1761 C CB  . SER A 1 283 ? 69.032  97.413  90.917  1.00 140.57 ? 283 SER A CB  1 
ATOM   1762 O OG  . SER A 1 283 ? 68.950  96.706  89.688  1.00 153.40 ? 283 SER A OG  1 
ATOM   1763 N N   . GLN A 1 284 ? 70.702  97.849  93.596  1.00 121.32 ? 284 GLN A N   1 
ATOM   1764 C CA  . GLN A 1 284 ? 70.724  98.371  94.955  1.00 135.70 ? 284 GLN A CA  1 
ATOM   1765 C C   . GLN A 1 284 ? 72.018  99.136  95.242  1.00 133.33 ? 284 GLN A C   1 
ATOM   1766 O O   . GLN A 1 284 ? 72.056  99.966  96.149  1.00 151.61 ? 284 GLN A O   1 
ATOM   1767 C CB  . GLN A 1 284 ? 70.559  97.227  95.959  1.00 159.41 ? 284 GLN A CB  1 
ATOM   1768 C CG  . GLN A 1 284 ? 69.264  96.434  95.801  1.00 183.95 ? 284 GLN A CG  1 
ATOM   1769 C CD  . GLN A 1 284 ? 68.022  97.274  95.992  1.00 204.42 ? 284 GLN A CD  1 
ATOM   1770 O OE1 . GLN A 1 284 ? 67.978  98.157  96.847  1.00 210.80 ? 284 GLN A OE1 1 
ATOM   1771 N NE2 . GLN A 1 284 ? 67.000  97.011  95.190  1.00 211.27 ? 284 GLN A NE2 1 
ATOM   1772 N N   . GLU A 1 285 ? 73.080  98.848  94.476  1.00 131.74 ? 285 GLU A N   1 
ATOM   1773 C CA  . GLU A 1 285 ? 74.382  99.481  94.643  1.00 129.85 ? 285 GLU A CA  1 
ATOM   1774 C C   . GLU A 1 285 ? 74.357  100.887 94.039  1.00 107.83 ? 285 GLU A C   1 
ATOM   1775 O O   . GLU A 1 285 ? 74.867  101.830 94.639  1.00 94.12  ? 285 GLU A O   1 
ATOM   1776 C CB  . GLU A 1 285 ? 75.474  98.634  93.981  1.00 154.08 ? 285 GLU A CB  1 
ATOM   1777 C CG  . GLU A 1 285 ? 75.367  97.139  94.260  1.00 170.60 ? 285 GLU A CG  1 
ATOM   1778 C CD  . GLU A 1 285 ? 75.535  96.717  95.710  1.00 203.31 ? 285 GLU A CD  1 
ATOM   1779 O OE1 . GLU A 1 285 ? 76.095  97.509  96.501  1.00 206.49 ? 285 GLU A OE1 1 
ATOM   1780 O OE2 . GLU A 1 285 ? 75.099  95.594  96.047  1.00 219.52 ? 285 GLU A OE2 1 
ATOM   1781 N N   . VAL A 1 286 ? 73.749  101.016 92.851  1.00 101.03 ? 286 VAL A N   1 
ATOM   1782 C CA  . VAL A 1 286 ? 73.600  102.289 92.160  1.00 96.16  ? 286 VAL A CA  1 
ATOM   1783 C C   . VAL A 1 286 ? 72.717  103.228 92.980  1.00 112.10 ? 286 VAL A C   1 
ATOM   1784 O O   . VAL A 1 286 ? 73.089  104.383 93.179  1.00 109.30 ? 286 VAL A O   1 
ATOM   1785 C CB  . VAL A 1 286 ? 73.051  102.098 90.730  1.00 102.22 ? 286 VAL A CB  1 
ATOM   1786 C CG1 . VAL A 1 286 ? 72.663  103.415 90.071  1.00 92.37  ? 286 VAL A CG1 1 
ATOM   1787 C CG2 . VAL A 1 286 ? 74.033  101.339 89.849  1.00 107.19 ? 286 VAL A CG2 1 
ATOM   1788 N N   . GLU A 1 287 ? 71.568  102.745 93.482  1.00 123.90 ? 287 GLU A N   1 
ATOM   1789 C CA  . GLU A 1 287 ? 70.629  103.613 94.182  1.00 125.16 ? 287 GLU A CA  1 
ATOM   1790 C C   . GLU A 1 287 ? 71.205  104.081 95.522  1.00 113.70 ? 287 GLU A C   1 
ATOM   1791 O O   . GLU A 1 287 ? 70.918  105.199 95.945  1.00 129.93 ? 287 GLU A O   1 
ATOM   1792 C CB  . GLU A 1 287 ? 69.262  102.943 94.343  1.00 139.62 ? 287 GLU A CB  1 
ATOM   1793 C CG  . GLU A 1 287 ? 68.158  103.900 94.792  1.00 173.58 ? 287 GLU A CG  1 
ATOM   1794 C CD  . GLU A 1 287 ? 67.875  105.091 93.882  1.00 192.64 ? 287 GLU A CD  1 
ATOM   1795 O OE1 . GLU A 1 287 ? 67.853  104.892 92.649  1.00 191.09 ? 287 GLU A OE1 1 
ATOM   1796 O OE2 . GLU A 1 287 ? 67.635  106.208 94.406  1.00 211.96 ? 287 GLU A OE2 1 
ATOM   1797 N N   . GLU A 1 288 ? 72.030  103.263 96.190  1.00 118.70 ? 288 GLU A N   1 
ATOM   1798 C CA  . GLU A 1 288 ? 72.680  103.664 97.433  1.00 129.77 ? 288 GLU A CA  1 
ATOM   1799 C C   . GLU A 1 288 ? 73.630  104.847 97.205  1.00 122.27 ? 288 GLU A C   1 
ATOM   1800 O O   . GLU A 1 288 ? 73.687  105.762 98.028  1.00 136.18 ? 288 GLU A O   1 
ATOM   1801 C CB  . GLU A 1 288 ? 73.416  102.473 98.055  1.00 150.36 ? 288 GLU A CB  1 
ATOM   1802 C CG  . GLU A 1 288 ? 74.068  102.780 99.393  1.00 184.16 ? 288 GLU A CG  1 
ATOM   1803 C CD  . GLU A 1 288 ? 74.715  101.584 100.078 1.00 201.46 ? 288 GLU A CD  1 
ATOM   1804 O OE1 . GLU A 1 288 ? 75.850  101.217 99.698  1.00 198.59 ? 288 GLU A OE1 1 
ATOM   1805 O OE2 . GLU A 1 288 ? 74.073  101.010 100.984 1.00 211.46 ? 288 GLU A OE2 1 
ATOM   1806 N N   . VAL A 1 289 ? 74.366  104.841 96.086  1.00 106.43 ? 289 VAL A N   1 
ATOM   1807 C CA  . VAL A 1 289 ? 75.308  105.905 95.762  1.00 103.52 ? 289 VAL A CA  1 
ATOM   1808 C C   . VAL A 1 289 ? 74.564  107.171 95.325  1.00 86.94  ? 289 VAL A C   1 
ATOM   1809 O O   . VAL A 1 289 ? 74.966  108.268 95.704  1.00 96.45  ? 289 VAL A O   1 
ATOM   1810 C CB  . VAL A 1 289 ? 76.335  105.446 94.704  1.00 116.36 ? 289 VAL A CB  1 
ATOM   1811 C CG1 . VAL A 1 289 ? 77.103  106.609 94.084  1.00 125.09 ? 289 VAL A CG1 1 
ATOM   1812 C CG2 . VAL A 1 289 ? 77.299  104.427 95.278  1.00 118.26 ? 289 VAL A CG2 1 
ATOM   1813 N N   . LEU A 1 290 ? 73.485  107.043 94.544  1.00 84.83  ? 290 LEU A N   1 
ATOM   1814 C CA  . LEU A 1 290 ? 72.678  108.199 94.180  1.00 91.88  ? 290 LEU A CA  1 
ATOM   1815 C C   . LEU A 1 290 ? 72.026  108.812 95.423  1.00 112.20 ? 290 LEU A C   1 
ATOM   1816 O O   . LEU A 1 290 ? 71.980  110.034 95.531  1.00 126.42 ? 290 LEU A O   1 
ATOM   1817 C CB  . LEU A 1 290 ? 71.612  107.805 93.153  1.00 94.69  ? 290 LEU A CB  1 
ATOM   1818 C CG  . LEU A 1 290 ? 72.110  107.536 91.738  1.00 101.87 ? 290 LEU A CG  1 
ATOM   1819 C CD1 . LEU A 1 290 ? 70.945  107.163 90.829  1.00 119.31 ? 290 LEU A CD1 1 
ATOM   1820 C CD2 . LEU A 1 290 ? 72.843  108.744 91.185  1.00 109.94 ? 290 LEU A CD2 1 
ATOM   1821 N N   . ALA A 1 291 ? 71.542  107.978 96.360  1.00 116.33 ? 291 ALA A N   1 
ATOM   1822 C CA  . ALA A 1 291 ? 70.936  108.456 97.595  1.00 121.24 ? 291 ALA A CA  1 
ATOM   1823 C C   . ALA A 1 291 ? 71.925  109.294 98.405  1.00 110.79 ? 291 ALA A C   1 
ATOM   1824 O O   . ALA A 1 291 ? 71.594  110.407 98.812  1.00 109.47 ? 291 ALA A O   1 
ATOM   1825 C CB  . ALA A 1 291 ? 70.404  107.294 98.402  1.00 132.97 ? 291 ALA A CB  1 
ATOM   1826 N N   . GLU A 1 292 ? 73.138  108.768 98.623  1.00 106.09 ? 292 GLU A N   1 
ATOM   1827 C CA  . GLU A 1 292 ? 74.151  109.441 99.424  1.00 103.72 ? 292 GLU A CA  1 
ATOM   1828 C C   . GLU A 1 292 ? 74.578  110.758 98.765  1.00 97.39  ? 292 GLU A C   1 
ATOM   1829 O O   . GLU A 1 292 ? 74.840  111.737 99.465  1.00 135.41 ? 292 GLU A O   1 
ATOM   1830 C CB  . GLU A 1 292 ? 75.325  108.493 99.688  1.00 125.50 ? 292 GLU A CB  1 
ATOM   1831 C CG  . GLU A 1 292 ? 76.179  108.882 100.889 1.00 162.79 ? 292 GLU A CG  1 
ATOM   1832 C CD  . GLU A 1 292 ? 77.332  109.840 100.629 1.00 188.71 ? 292 GLU A CD  1 
ATOM   1833 O OE1 . GLU A 1 292 ? 77.757  109.959 99.455  1.00 184.64 ? 292 GLU A OE1 1 
ATOM   1834 O OE2 . GLU A 1 292 ? 77.803  110.475 101.611 1.00 195.89 ? 292 GLU A OE2 1 
ATOM   1835 N N   . SER A 1 293 ? 74.591  110.815 97.429  1.00 98.76  ? 293 SER A N   1 
ATOM   1836 C CA  . SER A 1 293 ? 74.853  112.052 96.702  1.00 110.11 ? 293 SER A CA  1 
ATOM   1837 C C   . SER A 1 293 ? 73.707  113.060 96.855  1.00 116.30 ? 293 SER A C   1 
ATOM   1838 O O   . SER A 1 293 ? 73.973  114.243 97.060  1.00 124.20 ? 293 SER A O   1 
ATOM   1839 C CB  . SER A 1 293 ? 75.148  111.780 95.247  1.00 125.74 ? 293 SER A CB  1 
ATOM   1840 O OG  . SER A 1 293 ? 75.378  112.993 94.543  1.00 136.57 ? 293 SER A OG  1 
ATOM   1841 N N   . ARG A 1 294 ? 72.443  112.611 96.765  1.00 132.58 ? 294 ARG A N   1 
ATOM   1842 C CA  . ARG A 1 294 ? 71.291  113.489 96.961  1.00 151.20 ? 294 ARG A CA  1 
ATOM   1843 C C   . ARG A 1 294 ? 71.314  114.117 98.360  1.00 146.32 ? 294 ARG A C   1 
ATOM   1844 O O   . ARG A 1 294 ? 70.858  115.248 98.530  1.00 158.00 ? 294 ARG A O   1 
ATOM   1845 C CB  . ARG A 1 294 ? 69.971  112.746 96.700  1.00 171.45 ? 294 ARG A CB  1 
ATOM   1846 C CG  . ARG A 1 294 ? 69.684  112.472 95.228  1.00 186.45 ? 294 ARG A CG  1 
ATOM   1847 C CD  . ARG A 1 294 ? 68.322  111.849 94.937  1.00 191.58 ? 294 ARG A CD  1 
ATOM   1848 N NE  . ARG A 1 294 ? 68.031  110.660 95.737  1.00 195.72 ? 294 ARG A NE  1 
ATOM   1849 C CZ  . ARG A 1 294 ? 67.901  109.414 95.274  1.00 201.03 ? 294 ARG A CZ  1 
ATOM   1850 N NH1 . ARG A 1 294 ? 67.615  108.432 96.112  1.00 211.09 ? 294 ARG A NH1 1 
ATOM   1851 N NH2 . ARG A 1 294 ? 68.053  109.136 93.989  1.00 193.50 ? 294 ARG A NH2 1 
ATOM   1852 N N   . VAL A 1 295 ? 71.842  113.389 99.360  1.00 139.29 ? 295 VAL A N   1 
ATOM   1853 C CA  . VAL A 1 295 ? 72.077  113.927 100.697 1.00 126.40 ? 295 VAL A CA  1 
ATOM   1854 C C   . VAL A 1 295 ? 73.216  114.949 100.661 1.00 124.13 ? 295 VAL A C   1 
ATOM   1855 O O   . VAL A 1 295 ? 73.015  116.083 101.092 1.00 132.35 ? 295 VAL A O   1 
ATOM   1856 C CB  . VAL A 1 295 ? 72.331  112.804 101.726 1.00 131.00 ? 295 VAL A CB  1 
ATOM   1857 C CG1 . VAL A 1 295 ? 72.991  113.301 103.005 1.00 131.45 ? 295 VAL A CG1 1 
ATOM   1858 C CG2 . VAL A 1 295 ? 71.043  112.055 102.045 1.00 147.62 ? 295 VAL A CG2 1 
ATOM   1859 N N   . GLN A 1 296 ? 74.390  114.575 100.121 1.00 125.52 ? 296 GLN A N   1 
ATOM   1860 C CA  . GLN A 1 296 ? 75.589  115.406 100.185 1.00 127.96 ? 296 GLN A CA  1 
ATOM   1861 C C   . GLN A 1 296 ? 75.428  116.715 99.394  1.00 123.37 ? 296 GLN A C   1 
ATOM   1862 O O   . GLN A 1 296 ? 76.021  117.726 99.761  1.00 115.41 ? 296 GLN A O   1 
ATOM   1863 C CB  . GLN A 1 296 ? 76.805  114.602 99.717  1.00 133.36 ? 296 GLN A CB  1 
ATOM   1864 C CG  . GLN A 1 296 ? 78.137  115.320 99.909  1.00 150.61 ? 296 GLN A CG  1 
ATOM   1865 C CD  . GLN A 1 296 ? 79.331  114.486 99.502  1.00 168.15 ? 296 GLN A CD  1 
ATOM   1866 O OE1 . GLN A 1 296 ? 79.294  113.734 98.527  1.00 191.50 ? 296 GLN A OE1 1 
ATOM   1867 N NE2 . GLN A 1 296 ? 80.413  114.610 100.255 1.00 165.29 ? 296 GLN A NE2 1 
ATOM   1868 N N   . ARG A 1 297 ? 74.607  116.720 98.333  1.00 148.76 ? 297 ARG A N   1 
ATOM   1869 C CA  . ARG A 1 297 ? 74.361  117.911 97.525  1.00 168.54 ? 297 ARG A CA  1 
ATOM   1870 C C   . ARG A 1 297 ? 73.707  119.027 98.349  1.00 163.23 ? 297 ARG A C   1 
ATOM   1871 O O   . ARG A 1 297 ? 73.816  120.201 97.992  1.00 176.22 ? 297 ARG A O   1 
ATOM   1872 C CB  . ARG A 1 297 ? 73.486  117.534 96.321  1.00 215.34 ? 297 ARG A CB  1 
ATOM   1873 C CG  . ARG A 1 297 ? 73.271  118.643 95.299  1.00 241.12 ? 297 ARG A CG  1 
ATOM   1874 C CD  . ARG A 1 297 ? 72.488  118.158 94.091  1.00 268.29 ? 297 ARG A CD  1 
ATOM   1875 N NE  . ARG A 1 297 ? 71.131  117.735 94.422  1.00 289.50 ? 297 ARG A NE  1 
ATOM   1876 C CZ  . ARG A 1 297 ? 70.274  117.186 93.565  1.00 310.88 ? 297 ARG A CZ  1 
ATOM   1877 N NH1 . ARG A 1 297 ? 69.061  116.848 93.967  1.00 312.24 ? 297 ARG A NH1 1 
ATOM   1878 N NH2 . ARG A 1 297 ? 70.627  116.976 92.307  1.00 322.09 ? 297 ARG A NH2 1 
ATOM   1879 N N   . SER A 1 298 ? 73.026  118.668 99.449  1.00 170.70 ? 298 SER A N   1 
ATOM   1880 C CA  . SER A 1 298 ? 72.320  119.628 100.294 1.00 184.64 ? 298 SER A CA  1 
ATOM   1881 C C   . SER A 1 298 ? 73.255  120.379 101.251 1.00 175.47 ? 298 SER A C   1 
ATOM   1882 O O   . SER A 1 298 ? 72.822  121.339 101.889 1.00 178.19 ? 298 SER A O   1 
ATOM   1883 C CB  . SER A 1 298 ? 71.211  118.939 101.065 1.00 194.88 ? 298 SER A CB  1 
ATOM   1884 O OG  . SER A 1 298 ? 71.732  118.128 102.112 1.00 192.58 ? 298 SER A OG  1 
ATOM   1885 N N   . ILE A 1 299 ? 74.532  119.966 101.334 1.00 164.02 ? 299 ILE A N   1 
ATOM   1886 C CA  . ILE A 1 299 ? 75.458  120.392 102.382 1.00 147.11 ? 299 ILE A CA  1 
ATOM   1887 C C   . ILE A 1 299 ? 76.460  121.413 101.836 1.00 142.12 ? 299 ILE A C   1 
ATOM   1888 O O   . ILE A 1 299 ? 77.055  121.202 100.775 1.00 169.22 ? 299 ILE A O   1 
ATOM   1889 C CB  . ILE A 1 299 ? 76.173  119.154 102.965 1.00 158.30 ? 299 ILE A CB  1 
ATOM   1890 C CG1 . ILE A 1 299 ? 75.190  118.236 103.701 1.00 170.45 ? 299 ILE A CG1 1 
ATOM   1891 C CG2 . ILE A 1 299 ? 77.350  119.553 103.847 1.00 161.77 ? 299 ILE A CG2 1 
ATOM   1892 C CD1 . ILE A 1 299 ? 75.779  116.907 104.133 1.00 180.38 ? 299 ILE A CD1 1 
ATOM   1893 N N   . ARG A 1 300 ? 76.658  122.507 102.594 1.00 136.41 ? 300 ARG A N   1 
ATOM   1894 C CA  . ARG A 1 300 ? 77.652  123.532 102.294 1.00 132.85 ? 300 ARG A CA  1 
ATOM   1895 C C   . ARG A 1 300 ? 78.869  123.330 103.201 1.00 102.48 ? 300 ARG A C   1 
ATOM   1896 O O   . ARG A 1 300 ? 78.726  123.303 104.420 1.00 115.37 ? 300 ARG A O   1 
ATOM   1897 C CB  . ARG A 1 300 ? 77.003  124.915 102.451 1.00 147.57 ? 300 ARG A CB  1 
ATOM   1898 C CG  . ARG A 1 300 ? 77.950  126.097 102.292 1.00 163.03 ? 300 ARG A CG  1 
ATOM   1899 C CD  . ARG A 1 300 ? 78.444  126.650 103.616 1.00 184.40 ? 300 ARG A CD  1 
ATOM   1900 N NE  . ARG A 1 300 ? 79.658  127.444 103.474 1.00 213.27 ? 300 ARG A NE  1 
ATOM   1901 C CZ  . ARG A 1 300 ? 80.413  127.848 104.488 1.00 236.94 ? 300 ARG A CZ  1 
ATOM   1902 N NH1 . ARG A 1 300 ? 81.553  128.474 104.253 1.00 251.48 ? 300 ARG A NH1 1 
ATOM   1903 N NH2 . ARG A 1 300 ? 80.044  127.595 105.733 1.00 233.19 ? 300 ARG A NH2 1 
ATOM   1904 N N   . LEU A 1 301 ? 80.064  123.194 102.602 1.00 84.84  ? 301 LEU A N   1 
ATOM   1905 C CA  . LEU A 1 301 ? 81.259  122.768 103.314 1.00 82.29  ? 301 LEU A CA  1 
ATOM   1906 C C   . LEU A 1 301 ? 81.878  123.921 104.115 1.00 91.77  ? 301 LEU A C   1 
ATOM   1907 O O   . LEU A 1 301 ? 81.978  125.047 103.634 1.00 100.13 ? 301 LEU A O   1 
ATOM   1908 C CB  . LEU A 1 301 ? 82.286  122.236 102.312 1.00 89.36  ? 301 LEU A CB  1 
ATOM   1909 C CG  . LEU A 1 301 ? 81.879  121.027 101.473 1.00 106.44 ? 301 LEU A CG  1 
ATOM   1910 C CD1 . LEU A 1 301 ? 83.053  120.527 100.645 1.00 117.44 ? 301 LEU A CD1 1 
ATOM   1911 C CD2 . LEU A 1 301 ? 81.352  119.894 102.332 1.00 123.78 ? 301 LEU A CD2 1 
ATOM   1912 N N   . VAL A 1 302 ? 82.332  123.608 105.341 1.00 90.93  ? 302 VAL A N   1 
ATOM   1913 C CA  . VAL A 1 302 ? 83.016  124.558 106.197 1.00 85.68  ? 302 VAL A CA  1 
ATOM   1914 C C   . VAL A 1 302 ? 84.460  124.673 105.710 1.00 105.97 ? 302 VAL A C   1 
ATOM   1915 O O   . VAL A 1 302 ? 85.154  123.661 105.611 1.00 119.36 ? 302 VAL A O   1 
ATOM   1916 C CB  . VAL A 1 302 ? 82.936  124.127 107.676 1.00 100.18 ? 302 VAL A CB  1 
ATOM   1917 C CG1 . VAL A 1 302 ? 83.714  125.044 108.608 1.00 110.47 ? 302 VAL A CG1 1 
ATOM   1918 C CG2 . VAL A 1 302 ? 81.498  124.024 108.155 1.00 116.06 ? 302 VAL A CG2 1 
ATOM   1919 N N   . SER A 1 303 ? 84.911  125.912 105.431 1.00 103.83 ? 303 SER A N   1 
ATOM   1920 C CA  . SER A 1 303 ? 86.243  126.168 104.894 1.00 95.44  ? 303 SER A CA  1 
ATOM   1921 C C   . SER A 1 303 ? 87.307  126.033 105.983 1.00 83.78  ? 303 SER A C   1 
ATOM   1922 O O   . SER A 1 303 ? 86.989  126.108 107.168 1.00 98.65  ? 303 SER A O   1 
ATOM   1923 C CB  . SER A 1 303 ? 86.293  127.521 104.219 1.00 120.19 ? 303 SER A CB  1 
ATOM   1924 O OG  . SER A 1 303 ? 86.000  128.577 105.120 1.00 115.37 ? 303 SER A OG  1 
ATOM   1925 N N   . VAL A 1 304 ? 88.588  125.879 105.602 1.00 81.95  ? 304 VAL A N   1 
ATOM   1926 C CA  . VAL A 1 304 ? 89.638  125.510 106.550 1.00 73.60  ? 304 VAL A CA  1 
ATOM   1927 C C   . VAL A 1 304 ? 89.858  126.604 107.592 1.00 70.04  ? 304 VAL A C   1 
ATOM   1928 O O   . VAL A 1 304 ? 90.012  126.302 108.772 1.00 76.13  ? 304 VAL A O   1 
ATOM   1929 C CB  . VAL A 1 304 ? 90.949  125.118 105.848 1.00 75.71  ? 304 VAL A CB  1 
ATOM   1930 C CG1 . VAL A 1 304 ? 92.078  124.909 106.836 1.00 67.98  ? 304 VAL A CG1 1 
ATOM   1931 C CG2 . VAL A 1 304 ? 90.776  123.861 104.999 1.00 95.68  ? 304 VAL A CG2 1 
ATOM   1932 N N   . LEU A 1 305 ? 89.851  127.873 107.169 1.00 83.26  ? 305 LEU A N   1 
ATOM   1933 C CA  . LEU A 1 305 ? 90.074  128.994 108.072 1.00 86.22  ? 305 LEU A CA  1 
ATOM   1934 C C   . LEU A 1 305 ? 88.868  129.192 109.000 1.00 92.97  ? 305 LEU A C   1 
ATOM   1935 O O   . LEU A 1 305 ? 89.016  129.661 110.130 1.00 109.72 ? 305 LEU A O   1 
ATOM   1936 C CB  . LEU A 1 305 ? 90.357  130.234 107.219 1.00 85.27  ? 305 LEU A CB  1 
ATOM   1937 C CG  . LEU A 1 305 ? 90.552  131.545 107.972 1.00 103.01 ? 305 LEU A CG  1 
ATOM   1938 C CD1 . LEU A 1 305 ? 91.762  131.442 108.888 1.00 113.97 ? 305 LEU A CD1 1 
ATOM   1939 C CD2 . LEU A 1 305 ? 90.687  132.700 106.990 1.00 126.29 ? 305 LEU A CD2 1 
ATOM   1940 N N   . GLU A 1 306 ? 87.677  128.826 108.519 1.00 94.58  ? 306 GLU A N   1 
ATOM   1941 C CA  . GLU A 1 306 ? 86.408  128.943 109.228 1.00 102.61 ? 306 GLU A CA  1 
ATOM   1942 C C   . GLU A 1 306 ? 86.262  127.828 110.271 1.00 86.09  ? 306 GLU A C   1 
ATOM   1943 O O   . GLU A 1 306 ? 85.682  128.047 111.333 1.00 82.21  ? 306 GLU A O   1 
ATOM   1944 C CB  . GLU A 1 306 ? 85.344  128.920 108.128 1.00 131.23 ? 306 GLU A CB  1 
ATOM   1945 C CG  . GLU A 1 306 ? 83.891  129.019 108.544 1.00 156.76 ? 306 GLU A CG  1 
ATOM   1946 C CD  . GLU A 1 306 ? 82.980  128.801 107.344 1.00 190.66 ? 306 GLU A CD  1 
ATOM   1947 O OE1 . GLU A 1 306 ? 83.518  128.561 106.228 1.00 165.32 ? 306 GLU A OE1 1 
ATOM   1948 O OE2 . GLU A 1 306 ? 81.742  128.857 107.515 1.00 225.06 ? 306 GLU A OE2 1 
ATOM   1949 N N   . LEU A 1 307 ? 86.820  126.643 109.984 1.00 77.52  ? 307 LEU A N   1 
ATOM   1950 C CA  . LEU A 1 307 ? 86.919  125.547 110.945 1.00 68.25  ? 307 LEU A CA  1 
ATOM   1951 C C   . LEU A 1 307 ? 87.899  125.900 112.062 1.00 75.67  ? 307 LEU A C   1 
ATOM   1952 O O   . LEU A 1 307 ? 87.604  125.633 113.217 1.00 95.26  ? 307 LEU A O   1 
ATOM   1953 C CB  . LEU A 1 307 ? 87.361  124.278 110.208 1.00 65.76  ? 307 LEU A CB  1 
ATOM   1954 C CG  . LEU A 1 307 ? 87.305  122.973 110.986 1.00 63.97  ? 307 LEU A CG  1 
ATOM   1955 C CD1 . LEU A 1 307 ? 85.856  122.582 111.226 1.00 74.57  ? 307 LEU A CD1 1 
ATOM   1956 C CD2 . LEU A 1 307 ? 88.050  121.861 110.240 1.00 65.98  ? 307 LEU A CD2 1 
ATOM   1957 N N   . LEU A 1 308 ? 89.040  126.534 111.747 1.00 81.09  ? 308 LEU A N   1 
ATOM   1958 C CA  . LEU A 1 308 ? 89.984  127.002 112.760 1.00 74.28  ? 308 LEU A CA  1 
ATOM   1959 C C   . LEU A 1 308 ? 89.350  128.050 113.677 1.00 76.81  ? 308 LEU A C   1 
ATOM   1960 O O   . LEU A 1 308 ? 89.532  127.975 114.892 1.00 96.82  ? 308 LEU A O   1 
ATOM   1961 C CB  . LEU A 1 308 ? 91.234  127.577 112.089 1.00 67.67  ? 308 LEU A CB  1 
ATOM   1962 C CG  . LEU A 1 308 ? 92.191  126.555 111.481 1.00 69.72  ? 308 LEU A CG  1 
ATOM   1963 C CD1 . LEU A 1 308 ? 93.167  127.228 110.535 1.00 84.35  ? 308 LEU A CD1 1 
ATOM   1964 C CD2 . LEU A 1 308 ? 92.963  125.830 112.544 1.00 76.63  ? 308 LEU A CD2 1 
ATOM   1965 N N   . ARG A 1 309 ? 88.612  129.009 113.105 1.00 81.66  ? 309 ARG A N   1 
ATOM   1966 C CA  . ARG A 1 309 ? 88.047  130.130 113.850 1.00 108.54 ? 309 ARG A CA  1 
ATOM   1967 C C   . ARG A 1 309 ? 86.837  129.752 114.710 1.00 111.63 ? 309 ARG A C   1 
ATOM   1968 O O   . ARG A 1 309 ? 86.616  130.379 115.743 1.00 127.10 ? 309 ARG A O   1 
ATOM   1969 C CB  . ARG A 1 309 ? 87.644  131.253 112.891 1.00 122.91 ? 309 ARG A CB  1 
ATOM   1970 C CG  . ARG A 1 309 ? 88.827  132.065 112.387 1.00 146.13 ? 309 ARG A CG  1 
ATOM   1971 C CD  . ARG A 1 309 ? 88.421  133.061 111.320 1.00 161.21 ? 309 ARG A CD  1 
ATOM   1972 N NE  . ARG A 1 309 ? 89.521  133.940 110.950 1.00 178.89 ? 309 ARG A NE  1 
ATOM   1973 C CZ  . ARG A 1 309 ? 89.472  134.844 109.977 1.00 219.86 ? 309 ARG A CZ  1 
ATOM   1974 N NH1 . ARG A 1 309 ? 90.535  135.582 109.703 1.00 227.53 ? 309 ARG A NH1 1 
ATOM   1975 N NH2 . ARG A 1 309 ? 88.358  135.012 109.282 1.00 232.63 ? 309 ARG A NH2 1 
ATOM   1976 N N   . ALA A 1 310 ? 86.043  128.758 114.288 1.00 121.51 ? 310 ALA A N   1 
ATOM   1977 C CA  . ALA A 1 310 ? 84.809  128.377 114.976 1.00 121.31 ? 310 ALA A CA  1 
ATOM   1978 C C   . ALA A 1 310 ? 85.075  127.901 116.408 1.00 108.52 ? 310 ALA A C   1 
ATOM   1979 O O   . ALA A 1 310 ? 85.807  126.931 116.615 1.00 115.21 ? 310 ALA A O   1 
ATOM   1980 C CB  . ALA A 1 310 ? 84.110  127.295 114.182 1.00 119.92 ? 310 ALA A CB  1 
ATOM   1981 N N   . PRO A 1 311 ? 84.477  128.532 117.451 1.00 98.60  ? 311 PRO A N   1 
ATOM   1982 C CA  . PRO A 1 311 ? 84.701  128.105 118.834 1.00 99.79  ? 311 PRO A CA  1 
ATOM   1983 C C   . PRO A 1 311 ? 84.027  126.783 119.204 1.00 88.38  ? 311 PRO A C   1 
ATOM   1984 O O   . PRO A 1 311 ? 84.533  126.058 120.046 1.00 83.69  ? 311 PRO A O   1 
ATOM   1985 C CB  . PRO A 1 311 ? 84.138  129.273 119.667 1.00 104.01 ? 311 PRO A CB  1 
ATOM   1986 C CG  . PRO A 1 311 ? 83.087  129.897 118.781 1.00 107.55 ? 311 PRO A CG  1 
ATOM   1987 C CD  . PRO A 1 311 ? 83.590  129.701 117.367 1.00 102.90 ? 311 PRO A CD  1 
ATOM   1988 N N   . TYR A 1 312 ? 82.909  126.464 118.541 1.00 96.77  ? 312 TYR A N   1 
ATOM   1989 C CA  . TYR A 1 312 ? 82.107  125.287 118.843 1.00 86.91  ? 312 TYR A CA  1 
ATOM   1990 C C   . TYR A 1 312 ? 82.755  123.996 118.328 1.00 73.79  ? 312 TYR A C   1 
ATOM   1991 O O   . TYR A 1 312 ? 82.135  122.937 118.446 1.00 87.23  ? 312 TYR A O   1 
ATOM   1992 C CB  . TYR A 1 312 ? 80.698  125.493 118.268 1.00 109.79 ? 312 TYR A CB  1 
ATOM   1993 C CG  . TYR A 1 312 ? 80.632  125.760 116.767 1.00 116.45 ? 312 TYR A CG  1 
ATOM   1994 C CD1 . TYR A 1 312 ? 80.648  124.719 115.843 1.00 97.69  ? 312 TYR A CD1 1 
ATOM   1995 C CD2 . TYR A 1 312 ? 80.567  127.061 116.280 1.00 124.04 ? 312 TYR A CD2 1 
ATOM   1996 C CE1 . TYR A 1 312 ? 80.596  124.971 114.484 1.00 129.22 ? 312 TYR A CE1 1 
ATOM   1997 C CE2 . TYR A 1 312 ? 80.518  127.325 114.922 1.00 140.04 ? 312 TYR A CE2 1 
ATOM   1998 C CZ  . TYR A 1 312 ? 80.535  126.275 114.019 1.00 159.95 ? 312 TYR A CZ  1 
ATOM   1999 O OH  . TYR A 1 312 ? 80.489  126.526 112.673 1.00 172.89 ? 312 TYR A OH  1 
ATOM   2000 N N   . VAL A 1 313 ? 83.988  124.060 117.787 1.00 69.51  ? 313 VAL A N   1 
ATOM   2001 C CA  . VAL A 1 313 ? 84.794  122.875 117.499 1.00 71.25  ? 313 VAL A CA  1 
ATOM   2002 C C   . VAL A 1 313 ? 86.254  123.037 117.980 1.00 87.57  ? 313 VAL A C   1 
ATOM   2003 O O   . VAL A 1 313 ? 87.120  122.263 117.578 1.00 89.10  ? 313 VAL A O   1 
ATOM   2004 C CB  . VAL A 1 313 ? 84.771  122.498 116.007 1.00 62.19  ? 313 VAL A CB  1 
ATOM   2005 C CG1 . VAL A 1 313 ? 83.455  121.909 115.584 1.00 71.90  ? 313 VAL A CG1 1 
ATOM   2006 C CG2 . VAL A 1 313 ? 85.131  123.666 115.114 1.00 82.79  ? 313 VAL A CG2 1 
ATOM   2007 N N   . ARG A 1 314 ? 86.536  123.983 118.884 1.00 79.57  ? 314 ARG A N   1 
ATOM   2008 C CA  . ARG A 1 314 ? 87.907  124.332 119.229 1.00 78.81  ? 314 ARG A CA  1 
ATOM   2009 C C   . ARG A 1 314 ? 88.713  123.128 119.729 1.00 75.27  ? 314 ARG A C   1 
ATOM   2010 O O   . ARG A 1 314 ? 89.801  122.876 119.213 1.00 85.26  ? 314 ARG A O   1 
ATOM   2011 C CB  . ARG A 1 314 ? 87.965  125.474 120.249 1.00 91.74  ? 314 ARG A CB  1 
ATOM   2012 C CG  . ARG A 1 314 ? 89.371  126.011 120.466 1.00 99.79  ? 314 ARG A CG  1 
ATOM   2013 C CD  . ARG A 1 314 ? 89.430  127.167 121.460 1.00 145.14 ? 314 ARG A CD  1 
ATOM   2014 N NE  . ARG A 1 314 ? 90.801  127.458 121.897 1.00 204.80 ? 314 ARG A NE  1 
ATOM   2015 C CZ  . ARG A 1 314 ? 91.230  127.615 123.158 1.00 215.27 ? 314 ARG A CZ  1 
ATOM   2016 N NH1 . ARG A 1 314 ? 92.526  127.739 123.387 1.00 202.35 ? 314 ARG A NH1 1 
ATOM   2017 N NH2 . ARG A 1 314 ? 90.393  127.629 124.184 1.00 195.65 ? 314 ARG A NH2 1 
ATOM   2018 N N   . TRP A 1 315 ? 88.221  122.383 120.720 1.00 68.99  ? 315 TRP A N   1 
ATOM   2019 C CA  . TRP A 1 315 ? 88.997  121.283 121.288 1.00 60.49  ? 315 TRP A CA  1 
ATOM   2020 C C   . TRP A 1 315 ? 89.043  120.032 120.396 1.00 62.00  ? 315 TRP A C   1 
ATOM   2021 O O   . TRP A 1 315 ? 89.905  119.181 120.605 1.00 58.53  ? 315 TRP A O   1 
ATOM   2022 C CB  . TRP A 1 315 ? 88.507  120.963 122.706 1.00 56.96  ? 315 TRP A CB  1 
ATOM   2023 C CG  . TRP A 1 315 ? 88.914  122.046 123.661 1.00 75.20  ? 315 TRP A CG  1 
ATOM   2024 C CD1 . TRP A 1 315 ? 88.133  123.066 124.111 1.00 84.72  ? 315 TRP A CD1 1 
ATOM   2025 C CD2 . TRP A 1 315 ? 90.228  122.258 124.240 1.00 91.91  ? 315 TRP A CD2 1 
ATOM   2026 N NE1 . TRP A 1 315 ? 88.852  123.890 124.933 1.00 99.55  ? 315 TRP A NE1 1 
ATOM   2027 C CE2 . TRP A 1 315 ? 90.136  123.421 125.034 1.00 93.83  ? 315 TRP A CE2 1 
ATOM   2028 C CE3 . TRP A 1 315 ? 91.454  121.581 124.167 1.00 87.13  ? 315 TRP A CE3 1 
ATOM   2029 C CZ2 . TRP A 1 315 ? 91.223  123.924 125.736 1.00 105.97 ? 315 TRP A CZ2 1 
ATOM   2030 C CZ3 . TRP A 1 315 ? 92.531  122.089 124.845 1.00 94.48  ? 315 TRP A CZ3 1 
ATOM   2031 C CH2 . TRP A 1 315 ? 92.414  123.241 125.620 1.00 118.41 ? 315 TRP A CH2 1 
ATOM   2032 N N   . GLN A 1 316 ? 88.163  119.936 119.382 1.00 53.23  ? 316 GLN A N   1 
ATOM   2033 C CA  . GLN A 1 316 ? 88.284  118.909 118.368 1.00 53.78  ? 316 GLN A CA  1 
ATOM   2034 C C   . GLN A 1 316 ? 89.450  119.233 117.440 1.00 55.36  ? 316 GLN A C   1 
ATOM   2035 O O   . GLN A 1 316 ? 90.238  118.346 117.092 1.00 59.85  ? 316 GLN A O   1 
ATOM   2036 C CB  . GLN A 1 316 ? 86.984  118.744 117.577 1.00 61.90  ? 316 GLN A CB  1 
ATOM   2037 C CG  . GLN A 1 316 ? 85.857  118.091 118.350 1.00 67.18  ? 316 GLN A CG  1 
ATOM   2038 C CD  . GLN A 1 316 ? 84.781  119.032 118.825 1.00 69.26  ? 316 GLN A CD  1 
ATOM   2039 O OE1 . GLN A 1 316 ? 85.027  119.968 119.579 1.00 59.46  ? 316 GLN A OE1 1 
ATOM   2040 N NE2 . GLN A 1 316 ? 83.552  118.771 118.406 1.00 88.18  ? 316 GLN A NE2 1 
ATOM   2041 N N   . VAL A 1 317 ? 89.574  120.505 117.046 1.00 56.04  ? 317 VAL A N   1 
ATOM   2042 C CA  . VAL A 1 317 ? 90.674  120.951 116.194 1.00 62.76  ? 317 VAL A CA  1 
ATOM   2043 C C   . VAL A 1 317 ? 92.002  120.796 116.933 1.00 60.20  ? 317 VAL A C   1 
ATOM   2044 O O   . VAL A 1 317 ? 92.940  120.205 116.389 1.00 61.79  ? 317 VAL A O   1 
ATOM   2045 C CB  . VAL A 1 317 ? 90.431  122.385 115.683 1.00 57.85  ? 317 VAL A CB  1 
ATOM   2046 C CG1 . VAL A 1 317 ? 91.666  122.989 115.061 1.00 53.89  ? 317 VAL A CG1 1 
ATOM   2047 C CG2 . VAL A 1 317 ? 89.269  122.405 114.695 1.00 64.08  ? 317 VAL A CG2 1 
ATOM   2048 N N   . VAL A 1 318 ? 92.071  121.284 118.185 1.00 57.63  ? 318 VAL A N   1 
ATOM   2049 C CA  . VAL A 1 318 ? 93.286  121.179 118.986 1.00 56.79  ? 318 VAL A CA  1 
ATOM   2050 C C   . VAL A 1 318 ? 93.680  119.712 119.235 1.00 56.25  ? 318 VAL A C   1 
ATOM   2051 O O   . VAL A 1 318 ? 94.859  119.399 119.162 1.00 57.79  ? 318 VAL A O   1 
ATOM   2052 C CB  . VAL A 1 318 ? 93.166  121.995 120.285 1.00 54.46  ? 318 VAL A CB  1 
ATOM   2053 C CG1 . VAL A 1 318 ? 94.333  121.776 121.227 1.00 59.33  ? 318 VAL A CG1 1 
ATOM   2054 C CG2 . VAL A 1 318 ? 93.032  123.477 119.975 1.00 54.26  ? 318 VAL A CG2 1 
ATOM   2055 N N   . THR A 1 319 ? 92.714  118.807 119.462 1.00 60.80  ? 319 THR A N   1 
ATOM   2056 C CA  . THR A 1 319 ? 93.003  117.391 119.669 1.00 64.21  ? 319 THR A CA  1 
ATOM   2057 C C   . THR A 1 319 ? 93.546  116.727 118.401 1.00 57.86  ? 319 THR A C   1 
ATOM   2058 O O   . THR A 1 319 ? 94.374  115.819 118.495 1.00 58.85  ? 319 THR A O   1 
ATOM   2059 C CB  . THR A 1 319 ? 91.792  116.638 120.234 1.00 62.35  ? 319 THR A CB  1 
ATOM   2060 O OG1 . THR A 1 319 ? 91.475  117.238 121.484 1.00 61.36  ? 319 THR A OG1 1 
ATOM   2061 C CG2 . THR A 1 319 ? 92.054  115.169 120.473 1.00 69.47  ? 319 THR A CG2 1 
ATOM   2062 N N   . VAL A 1 320 ? 93.104  117.180 117.215 1.00 60.56  ? 320 VAL A N   1 
ATOM   2063 C CA  . VAL A 1 320 ? 93.614  116.651 115.953 1.00 60.63  ? 320 VAL A CA  1 
ATOM   2064 C C   . VAL A 1 320 ? 95.041  117.147 115.704 1.00 64.60  ? 320 VAL A C   1 
ATOM   2065 O O   . VAL A 1 320 ? 95.908  116.366 115.313 1.00 64.73  ? 320 VAL A O   1 
ATOM   2066 C CB  . VAL A 1 320 ? 92.665  116.964 114.788 1.00 56.11  ? 320 VAL A CB  1 
ATOM   2067 C CG1 . VAL A 1 320 ? 93.353  116.851 113.436 1.00 59.70  ? 320 VAL A CG1 1 
ATOM   2068 C CG2 . VAL A 1 320 ? 91.444  116.058 114.845 1.00 66.33  ? 320 VAL A CG2 1 
ATOM   2069 N N   . ILE A 1 321 ? 95.311  118.431 115.981 1.00 71.28  ? 321 ILE A N   1 
ATOM   2070 C CA  . ILE A 1 321 ? 96.641  118.989 115.769 1.00 62.78  ? 321 ILE A CA  1 
ATOM   2071 C C   . ILE A 1 321 ? 97.630  118.322 116.730 1.00 65.73  ? 321 ILE A C   1 
ATOM   2072 O O   . ILE A 1 321 ? 98.700  117.911 116.302 1.00 84.56  ? 321 ILE A O   1 
ATOM   2073 C CB  . ILE A 1 321 ? 96.622  120.527 115.896 1.00 58.70  ? 321 ILE A CB  1 
ATOM   2074 C CG1 . ILE A 1 321 ? 95.785  121.172 114.794 1.00 55.27  ? 321 ILE A CG1 1 
ATOM   2075 C CG2 . ILE A 1 321 ? 98.027  121.088 115.896 1.00 59.11  ? 321 ILE A CG2 1 
ATOM   2076 C CD1 . ILE A 1 321 ? 95.476  122.641 115.033 1.00 62.34  ? 321 ILE A CD1 1 
ATOM   2077 N N   . VAL A 1 322 ? 97.284  118.171 118.017 1.00 67.28  ? 322 VAL A N   1 
ATOM   2078 C CA  . VAL A 1 322 ? 98.177  117.565 119.005 1.00 59.02  ? 322 VAL A CA  1 
ATOM   2079 C C   . VAL A 1 322 ? 98.429  116.083 118.691 1.00 59.44  ? 322 VAL A C   1 
ATOM   2080 O O   . VAL A 1 322 ? 99.549  115.612 118.874 1.00 74.20  ? 322 VAL A O   1 
ATOM   2081 C CB  . VAL A 1 322 ? 97.633  117.749 120.435 1.00 51.29  ? 322 VAL A CB  1 
ATOM   2082 C CG1 . VAL A 1 322 ? 98.322  116.857 121.450 1.00 57.08  ? 322 VAL A CG1 1 
ATOM   2083 C CG2 . VAL A 1 322 ? 97.717  119.199 120.861 1.00 55.59  ? 322 VAL A CG2 1 
ATOM   2084 N N   . THR A 1 323 ? 97.412  115.343 118.226 1.00 60.14  ? 323 THR A N   1 
ATOM   2085 C CA  . THR A 1 323 ? 97.557  113.923 117.969 1.00 67.46  ? 323 THR A CA  1 
ATOM   2086 C C   . THR A 1 323 ? 98.385  113.689 116.707 1.00 67.17  ? 323 THR A C   1 
ATOM   2087 O O   . THR A 1 323 ? 99.204  112.775 116.682 1.00 66.76  ? 323 THR A O   1 
ATOM   2088 C CB  . THR A 1 323 ? 96.200  113.208 117.852 1.00 77.64  ? 323 THR A CB  1 
ATOM   2089 O OG1 . THR A 1 323 ? 95.428  113.454 119.025 1.00 69.14  ? 323 THR A OG1 1 
ATOM   2090 C CG2 . THR A 1 323 ? 96.340  111.712 117.675 1.00 84.57  ? 323 THR A CG2 1 
ATOM   2091 N N   . MET A 1 324 ? 98.173  114.496 115.657 1.00 69.57  ? 324 MET A N   1 
ATOM   2092 C CA  . MET A 1 324 ? 98.910  114.348 114.405 1.00 72.56  ? 324 MET A CA  1 
ATOM   2093 C C   . MET A 1 324 ? 100.362 114.833 114.536 1.00 66.95  ? 324 MET A C   1 
ATOM   2094 O O   . MET A 1 324 ? 101.236 114.327 113.844 1.00 70.21  ? 324 MET A O   1 
ATOM   2095 C CB  . MET A 1 324 ? 98.224  115.106 113.272 1.00 67.52  ? 324 MET A CB  1 
ATOM   2096 C CG  . MET A 1 324 ? 96.933  114.455 112.870 1.00 83.00  ? 324 MET A CG  1 
ATOM   2097 S SD  . MET A 1 324 ? 97.132  112.835 112.124 1.00 91.91  ? 324 MET A SD  1 
ATOM   2098 C CE  . MET A 1 324 ? 95.394  112.380 112.003 1.00 123.88 ? 324 MET A CE  1 
ATOM   2099 N N   . ALA A 1 325 ? 100.617 115.794 115.428 1.00 62.24  ? 325 ALA A N   1 
ATOM   2100 C CA  . ALA A 1 325 ? 101.966 116.172 115.796 1.00 65.69  ? 325 ALA A CA  1 
ATOM   2101 C C   . ALA A 1 325 ? 102.664 115.012 116.528 1.00 72.70  ? 325 ALA A C   1 
ATOM   2102 O O   . ALA A 1 325 ? 103.723 114.580 116.094 1.00 82.63  ? 325 ALA A O   1 
ATOM   2103 C CB  . ALA A 1 325 ? 101.945 117.434 116.621 1.00 65.10  ? 325 ALA A CB  1 
ATOM   2104 N N   . CYS A 1 326 ? 102.081 114.467 117.600 1.00 66.88  ? 326 CYS A N   1 
ATOM   2105 C CA  . CYS A 1 326 ? 102.743 113.429 118.376 1.00 69.96  ? 326 CYS A CA  1 
ATOM   2106 C C   . CYS A 1 326 ? 102.895 112.117 117.597 1.00 67.56  ? 326 CYS A C   1 
ATOM   2107 O O   . CYS A 1 326 ? 103.831 111.372 117.845 1.00 79.59  ? 326 CYS A O   1 
ATOM   2108 C CB  . CYS A 1 326 ? 102.020 113.200 119.699 1.00 79.54  ? 326 CYS A CB  1 
ATOM   2109 S SG  . CYS A 1 326 ? 102.066 114.680 120.748 1.00 100.36 ? 326 CYS A SG  1 
ATOM   2110 N N   . TYR A 1 327 ? 102.027 111.852 116.623 1.00 66.42  ? 327 TYR A N   1 
ATOM   2111 C CA  . TYR A 1 327 ? 102.132 110.685 115.755 1.00 64.46  ? 327 TYR A CA  1 
ATOM   2112 C C   . TYR A 1 327 ? 103.426 110.700 114.947 1.00 64.42  ? 327 TYR A C   1 
ATOM   2113 O O   . TYR A 1 327 ? 103.974 109.636 114.659 1.00 82.06  ? 327 TYR A O   1 
ATOM   2114 C CB  . TYR A 1 327 ? 100.910 110.713 114.828 1.00 73.10  ? 327 TYR A CB  1 
ATOM   2115 C CG  . TYR A 1 327 ? 100.790 109.601 113.804 1.00 72.10  ? 327 TYR A CG  1 
ATOM   2116 C CD1 . TYR A 1 327 ? 100.386 108.337 114.168 1.00 84.79  ? 327 TYR A CD1 1 
ATOM   2117 C CD2 . TYR A 1 327 ? 101.069 109.821 112.467 1.00 95.28  ? 327 TYR A CD2 1 
ATOM   2118 C CE1 . TYR A 1 327 ? 100.254 107.327 113.228 1.00 102.32 ? 327 TYR A CE1 1 
ATOM   2119 C CE2 . TYR A 1 327 ? 100.971 108.815 111.519 1.00 91.49  ? 327 TYR A CE2 1 
ATOM   2120 C CZ  . TYR A 1 327 ? 100.553 107.560 111.900 1.00 104.41 ? 327 TYR A CZ  1 
ATOM   2121 O OH  . TYR A 1 327 ? 100.440 106.539 110.998 1.00 131.77 ? 327 TYR A OH  1 
ATOM   2122 N N   . GLN A 1 328 ? 103.919 111.892 114.571 1.00 65.01  ? 328 GLN A N   1 
ATOM   2123 C CA  . GLN A 1 328 ? 105.156 112.034 113.813 1.00 76.58  ? 328 GLN A CA  1 
ATOM   2124 C C   . GLN A 1 328 ? 106.339 112.394 114.721 1.00 71.64  ? 328 GLN A C   1 
ATOM   2125 O O   . GLN A 1 328 ? 107.412 111.807 114.577 1.00 83.77  ? 328 GLN A O   1 
ATOM   2126 C CB  . GLN A 1 328 ? 104.990 113.059 112.690 1.00 70.78  ? 328 GLN A CB  1 
ATOM   2127 C CG  . GLN A 1 328 ? 104.007 112.613 111.613 1.00 77.82  ? 328 GLN A CG  1 
ATOM   2128 C CD  . GLN A 1 328 ? 104.506 111.473 110.759 1.00 83.94  ? 328 GLN A CD  1 
ATOM   2129 O OE1 . GLN A 1 328 ? 105.592 110.938 110.967 1.00 108.50 ? 328 GLN A OE1 1 
ATOM   2130 N NE2 . GLN A 1 328 ? 103.727 111.103 109.760 1.00 82.23  ? 328 GLN A NE2 1 
ATOM   2131 N N   . LEU A 1 329 ? 106.146 113.359 115.623 1.00 69.10  ? 329 LEU A N   1 
ATOM   2132 C CA  . LEU A 1 329 ? 107.204 113.854 116.499 1.00 67.20  ? 329 LEU A CA  1 
ATOM   2133 C C   . LEU A 1 329 ? 107.584 112.833 117.572 1.00 70.88  ? 329 LEU A C   1 
ATOM   2134 O O   . LEU A 1 329 ? 108.553 113.073 118.287 1.00 87.31  ? 329 LEU A O   1 
ATOM   2135 C CB  . LEU A 1 329 ? 106.754 115.161 117.164 1.00 74.63  ? 329 LEU A CB  1 
ATOM   2136 C CG  . LEU A 1 329 ? 106.520 116.360 116.246 1.00 73.67  ? 329 LEU A CG  1 
ATOM   2137 C CD1 . LEU A 1 329 ? 106.206 117.604 117.064 1.00 79.52  ? 329 LEU A CD1 1 
ATOM   2138 C CD2 . LEU A 1 329 ? 107.728 116.603 115.367 1.00 76.39  ? 329 LEU A CD2 1 
ATOM   2139 N N   . CYS A 1 330 ? 106.864 111.704 117.693 1.00 73.91  ? 330 CYS A N   1 
ATOM   2140 C CA  . CYS A 1 330 ? 107.332 110.594 118.523 1.00 82.86  ? 330 CYS A CA  1 
ATOM   2141 C C   . CYS A 1 330 ? 108.589 109.947 117.925 1.00 85.65  ? 330 CYS A C   1 
ATOM   2142 O O   . CYS A 1 330 ? 109.186 109.078 118.557 1.00 92.15  ? 330 CYS A O   1 
ATOM   2143 C CB  . CYS A 1 330 ? 106.264 109.516 118.678 1.00 90.49  ? 330 CYS A CB  1 
ATOM   2144 S SG  . CYS A 1 330 ? 105.862 108.639 117.135 1.00 82.84  ? 330 CYS A SG  1 
ATOM   2145 N N   . GLY A 1 331 ? 108.967 110.328 116.696 1.00 80.04  ? 331 GLY A N   1 
ATOM   2146 C CA  . GLY A 1 331 ? 110.271 110.009 116.134 1.00 80.94  ? 331 GLY A CA  1 
ATOM   2147 C C   . GLY A 1 331 ? 110.350 108.618 115.498 1.00 81.36  ? 331 GLY A C   1 
ATOM   2148 O O   . GLY A 1 331 ? 111.451 108.125 115.264 1.00 93.98  ? 331 GLY A O   1 
ATOM   2149 N N   . LEU A 1 332 ? 109.219 107.990 115.178 1.00 78.37  ? 332 LEU A N   1 
ATOM   2150 C CA  . LEU A 1 332 ? 109.285 106.662 114.595 1.00 84.40  ? 332 LEU A CA  1 
ATOM   2151 C C   . LEU A 1 332 ? 109.880 106.718 113.181 1.00 90.89  ? 332 LEU A C   1 
ATOM   2152 O O   . LEU A 1 332 ? 110.550 105.773 112.757 1.00 85.46  ? 332 LEU A O   1 
ATOM   2153 C CB  . LEU A 1 332 ? 107.912 105.982 114.588 1.00 94.90  ? 332 LEU A CB  1 
ATOM   2154 C CG  . LEU A 1 332 ? 107.999 104.463 114.450 1.00 110.25 ? 332 LEU A CG  1 
ATOM   2155 C CD1 . LEU A 1 332 ? 108.069 103.814 115.829 1.00 118.41 ? 332 LEU A CD1 1 
ATOM   2156 C CD2 . LEU A 1 332 ? 106.875 103.894 113.587 1.00 108.57 ? 332 LEU A CD2 1 
ATOM   2157 N N   . ASN A 1 333 ? 109.671 107.819 112.448 1.00 93.28  ? 333 ASN A N   1 
ATOM   2158 C CA  . ASN A 1 333 ? 110.285 107.964 111.135 1.00 88.34  ? 333 ASN A CA  1 
ATOM   2159 C C   . ASN A 1 333 ? 111.806 108.142 111.239 1.00 78.37  ? 333 ASN A C   1 
ATOM   2160 O O   . ASN A 1 333 ? 112.520 107.728 110.331 1.00 89.63  ? 333 ASN A O   1 
ATOM   2161 C CB  . ASN A 1 333 ? 109.603 109.058 110.312 1.00 99.56  ? 333 ASN A CB  1 
ATOM   2162 C CG  . ASN A 1 333 ? 108.469 108.496 109.493 1.00 103.53 ? 333 ASN A CG  1 
ATOM   2163 O OD1 . ASN A 1 333 ? 108.695 107.629 108.662 1.00 105.28 ? 333 ASN A OD1 1 
ATOM   2164 N ND2 . ASN A 1 333 ? 107.251 108.948 109.736 1.00 112.51 ? 333 ASN A ND2 1 
ATOM   2165 N N   . ALA A 1 334 ? 112.314 108.728 112.329 1.00 65.09  ? 334 ALA A N   1 
ATOM   2166 C CA  . ALA A 1 334 ? 113.749 108.789 112.544 1.00 73.51  ? 334 ALA A CA  1 
ATOM   2167 C C   . ALA A 1 334 ? 114.338 107.386 112.684 1.00 74.65  ? 334 ALA A C   1 
ATOM   2168 O O   . ALA A 1 334 ? 115.534 107.204 112.501 1.00 80.81  ? 334 ALA A O   1 
ATOM   2169 C CB  . ALA A 1 334 ? 114.089 109.650 113.757 1.00 87.90  ? 334 ALA A CB  1 
ATOM   2170 N N   . ILE A 1 335 ? 113.533 106.380 113.050 1.00 76.30  ? 335 ILE A N   1 
ATOM   2171 C CA  . ILE A 1 335 ? 113.994 104.998 113.091 1.00 74.44  ? 335 ILE A CA  1 
ATOM   2172 C C   . ILE A 1 335 ? 114.120 104.439 111.664 1.00 66.31  ? 335 ILE A C   1 
ATOM   2173 O O   . ILE A 1 335 ? 115.009 103.630 111.437 1.00 69.04  ? 335 ILE A O   1 
ATOM   2174 C CB  . ILE A 1 335 ? 113.103 104.140 114.016 1.00 80.93  ? 335 ILE A CB  1 
ATOM   2175 C CG1 . ILE A 1 335 ? 113.122 104.710 115.443 1.00 86.36  ? 335 ILE A CG1 1 
ATOM   2176 C CG2 . ILE A 1 335 ? 113.499 102.659 113.978 1.00 83.10  ? 335 ILE A CG2 1 
ATOM   2177 C CD1 . ILE A 1 335 ? 112.196 103.994 116.431 1.00 95.91  ? 335 ILE A CD1 1 
ATOM   2178 N N   . TRP A 1 336 ? 113.285 104.863 110.696 1.00 57.10  ? 336 TRP A N   1 
ATOM   2179 C CA  . TRP A 1 336 ? 113.398 104.340 109.337 1.00 54.63  ? 336 TRP A CA  1 
ATOM   2180 C C   . TRP A 1 336 ? 114.501 105.059 108.556 1.00 65.73  ? 336 TRP A C   1 
ATOM   2181 O O   . TRP A 1 336 ? 115.263 104.411 107.841 1.00 68.60  ? 336 TRP A O   1 
ATOM   2182 C CB  . TRP A 1 336 ? 112.078 104.394 108.545 1.00 55.63  ? 336 TRP A CB  1 
ATOM   2183 C CG  . TRP A 1 336 ? 110.904 103.750 109.226 1.00 64.37  ? 336 TRP A CG  1 
ATOM   2184 C CD1 . TRP A 1 336 ? 109.669 104.306 109.371 1.00 76.14  ? 336 TRP A CD1 1 
ATOM   2185 C CD2 . TRP A 1 336 ? 110.855 102.476 109.909 1.00 71.85  ? 336 TRP A CD2 1 
ATOM   2186 N NE1 . TRP A 1 336 ? 108.854 103.485 110.098 1.00 82.22  ? 336 TRP A NE1 1 
ATOM   2187 C CE2 . TRP A 1 336 ? 109.557 102.359 110.445 1.00 73.20  ? 336 TRP A CE2 1 
ATOM   2188 C CE3 . TRP A 1 336 ? 111.763 101.439 110.151 1.00 77.29  ? 336 TRP A CE3 1 
ATOM   2189 C CZ2 . TRP A 1 336 ? 109.159 101.261 111.201 1.00 81.91  ? 336 TRP A CZ2 1 
ATOM   2190 C CZ3 . TRP A 1 336 ? 111.359 100.349 110.887 1.00 83.38  ? 336 TRP A CZ3 1 
ATOM   2191 C CH2 . TRP A 1 336 ? 110.083 100.269 111.434 1.00 86.43  ? 336 TRP A CH2 1 
ATOM   2192 N N   . PHE A 1 337 ? 114.584 106.392 108.678 1.00 62.37  ? 337 PHE A N   1 
ATOM   2193 C CA  . PHE A 1 337 ? 115.544 107.183 107.936 1.00 51.90  ? 337 PHE A CA  1 
ATOM   2194 C C   . PHE A 1 337 ? 116.974 106.972 108.433 1.00 54.85  ? 337 PHE A C   1 
ATOM   2195 O O   . PHE A 1 337 ? 117.916 107.199 107.662 1.00 74.24  ? 337 PHE A O   1 
ATOM   2196 C CB  . PHE A 1 337 ? 115.255 108.678 108.059 1.00 59.47  ? 337 PHE A CB  1 
ATOM   2197 C CG  . PHE A 1 337 ? 113.941 109.195 107.528 1.00 65.63  ? 337 PHE A CG  1 
ATOM   2198 C CD1 . PHE A 1 337 ? 113.435 108.756 106.319 1.00 71.32  ? 337 PHE A CD1 1 
ATOM   2199 C CD2 . PHE A 1 337 ? 113.273 110.211 108.203 1.00 62.79  ? 337 PHE A CD2 1 
ATOM   2200 C CE1 . PHE A 1 337 ? 112.257 109.287 105.819 1.00 90.54  ? 337 PHE A CE1 1 
ATOM   2201 C CE2 . PHE A 1 337 ? 112.094 110.736 107.701 1.00 76.69  ? 337 PHE A CE2 1 
ATOM   2202 C CZ  . PHE A 1 337 ? 111.589 110.271 106.506 1.00 89.37  ? 337 PHE A CZ  1 
ATOM   2203 N N   . TYR A 1 338 ? 117.168 106.588 109.710 1.00 49.62  ? 338 TYR A N   1 
ATOM   2204 C CA  . TYR A 1 338 ? 118.477 106.694 110.351 1.00 53.56  ? 338 TYR A CA  1 
ATOM   2205 C C   . TYR A 1 338 ? 118.885 105.440 111.123 1.00 52.75  ? 338 TYR A C   1 
ATOM   2206 O O   . TYR A 1 338 ? 119.799 105.535 111.934 1.00 54.18  ? 338 TYR A O   1 
ATOM   2207 C CB  . TYR A 1 338 ? 118.534 107.923 111.273 1.00 47.69  ? 338 TYR A CB  1 
ATOM   2208 C CG  . TYR A 1 338 ? 118.393 109.279 110.578 1.00 58.15  ? 338 TYR A CG  1 
ATOM   2209 C CD1 . TYR A 1 338 ? 119.387 109.759 109.739 1.00 74.64  ? 338 TYR A CD1 1 
ATOM   2210 C CD2 . TYR A 1 338 ? 117.262 110.067 110.729 1.00 51.40  ? 338 TYR A CD2 1 
ATOM   2211 C CE1 . TYR A 1 338 ? 119.259 110.964 109.061 1.00 69.50  ? 338 TYR A CE1 1 
ATOM   2212 C CE2 . TYR A 1 338 ? 117.120 111.272 110.065 1.00 55.30  ? 338 TYR A CE2 1 
ATOM   2213 C CZ  . TYR A 1 338 ? 118.119 111.727 109.223 1.00 58.64  ? 338 TYR A CZ  1 
ATOM   2214 O OH  . TYR A 1 338 ? 118.028 112.922 108.569 1.00 58.67  ? 338 TYR A OH  1 
ATOM   2215 N N   . THR A 1 339 ? 118.324 104.260 110.801 1.00 55.79  ? 339 THR A N   1 
ATOM   2216 C CA  . THR A 1 339 ? 118.456 103.084 111.660 1.00 60.99  ? 339 THR A CA  1 
ATOM   2217 C C   . THR A 1 339 ? 119.911 102.648 111.849 1.00 55.20  ? 339 THR A C   1 
ATOM   2218 O O   . THR A 1 339 ? 120.297 102.292 112.957 1.00 67.66  ? 339 THR A O   1 
ATOM   2219 C CB  . THR A 1 339 ? 117.690 101.851 111.150 1.00 64.04  ? 339 THR A CB  1 
ATOM   2220 O OG1 . THR A 1 339 ? 116.743 102.178 110.139 1.00 71.94  ? 339 THR A OG1 1 
ATOM   2221 C CG2 . THR A 1 339 ? 116.963 101.133 112.266 1.00 70.50  ? 339 THR A CG2 1 
ATOM   2222 N N   . ASN A 1 340 ? 120.706 102.613 110.779 1.00 54.51  ? 340 ASN A N   1 
ATOM   2223 C CA  . ASN A 1 340 ? 122.040 102.037 110.838 1.00 56.56  ? 340 ASN A CA  1 
ATOM   2224 C C   . ASN A 1 340 ? 122.982 102.931 111.644 1.00 60.83  ? 340 ASN A C   1 
ATOM   2225 O O   . ASN A 1 340 ? 123.987 102.434 112.161 1.00 66.85  ? 340 ASN A O   1 
ATOM   2226 C CB  . ASN A 1 340 ? 122.628 101.777 109.442 1.00 66.31  ? 340 ASN A CB  1 
ATOM   2227 C CG  . ASN A 1 340 ? 122.020 100.587 108.738 1.00 69.70  ? 340 ASN A CG  1 
ATOM   2228 O OD1 . ASN A 1 340 ? 120.914 100.174 109.062 1.00 74.03  ? 340 ASN A OD1 1 
ATOM   2229 N ND2 . ASN A 1 340 ? 122.723 100.047 107.753 1.00 84.66  ? 340 ASN A ND2 1 
ATOM   2230 N N   . SER A 1 341 ? 122.691 104.239 111.751 1.00 67.27  ? 341 SER A N   1 
ATOM   2231 C CA  . SER A 1 341 ? 123.468 105.131 112.608 1.00 77.08  ? 341 SER A CA  1 
ATOM   2232 C C   . SER A 1 341 ? 123.109 104.924 114.082 1.00 70.04  ? 341 SER A C   1 
ATOM   2233 O O   . SER A 1 341 ? 123.993 104.943 114.938 1.00 78.71  ? 341 SER A O   1 
ATOM   2234 C CB  . SER A 1 341 ? 123.309 106.577 112.204 1.00 80.67  ? 341 SER A CB  1 
ATOM   2235 O OG  . SER A 1 341 ? 122.063 107.103 112.618 1.00 74.80  ? 341 SER A OG  1 
ATOM   2236 N N   . ILE A 1 342 ? 121.817 104.703 114.364 1.00 61.28  ? 342 ILE A N   1 
ATOM   2237 C CA  . ILE A 1 342 ? 121.328 104.467 115.714 1.00 60.59  ? 342 ILE A CA  1 
ATOM   2238 C C   . ILE A 1 342 ? 121.931 103.177 116.270 1.00 58.73  ? 342 ILE A C   1 
ATOM   2239 O O   . ILE A 1 342 ? 122.418 103.181 117.399 1.00 63.63  ? 342 ILE A O   1 
ATOM   2240 C CB  . ILE A 1 342 ? 119.782 104.484 115.733 1.00 64.43  ? 342 ILE A CB  1 
ATOM   2241 C CG1 . ILE A 1 342 ? 119.251 105.899 115.467 1.00 60.81  ? 342 ILE A CG1 1 
ATOM   2242 C CG2 . ILE A 1 342 ? 119.226 103.902 117.028 1.00 61.46  ? 342 ILE A CG2 1 
ATOM   2243 C CD1 . ILE A 1 342 ? 117.797 105.971 115.057 1.00 65.46  ? 342 ILE A CD1 1 
ATOM   2244 N N   . PHE A 1 343 ? 121.922 102.083 115.492 1.00 59.79  ? 343 PHE A N   1 
ATOM   2245 C CA  . PHE A 1 343 ? 122.516 100.823 115.923 1.00 62.72  ? 343 PHE A CA  1 
ATOM   2246 C C   . PHE A 1 343 ? 124.045 100.918 116.007 1.00 68.84  ? 343 PHE A C   1 
ATOM   2247 O O   . PHE A 1 343 ? 124.651 100.245 116.834 1.00 76.04  ? 343 PHE A O   1 
ATOM   2248 C CB  . PHE A 1 343 ? 122.067 99.659  115.044 1.00 53.29  ? 343 PHE A CB  1 
ATOM   2249 C CG  . PHE A 1 343 ? 120.644 99.216  115.272 1.00 65.88  ? 343 PHE A CG  1 
ATOM   2250 C CD1 . PHE A 1 343 ? 120.191 98.873  116.535 1.00 82.67  ? 343 PHE A CD1 1 
ATOM   2251 C CD2 . PHE A 1 343 ? 119.757 99.112  114.213 1.00 82.30  ? 343 PHE A CD2 1 
ATOM   2252 C CE1 . PHE A 1 343 ? 118.881 98.451  116.726 1.00 80.78  ? 343 PHE A CE1 1 
ATOM   2253 C CE2 . PHE A 1 343 ? 118.454 98.684  114.403 1.00 83.94  ? 343 PHE A CE2 1 
ATOM   2254 C CZ  . PHE A 1 343 ? 118.017 98.357  115.661 1.00 78.63  ? 343 PHE A CZ  1 
ATOM   2255 N N   . GLY A 1 344 ? 124.668 101.762 115.186 1.00 63.40  ? 344 GLY A N   1 
ATOM   2256 C CA  . GLY A 1 344 ? 126.097 102.007 115.284 1.00 67.52  ? 344 GLY A CA  1 
ATOM   2257 C C   . GLY A 1 344 ? 126.504 102.655 116.601 1.00 69.64  ? 344 GLY A C   1 
ATOM   2258 O O   . GLY A 1 344 ? 127.480 102.216 117.211 1.00 90.78  ? 344 GLY A O   1 
ATOM   2259 N N   . LYS A 1 345 ? 125.781 103.709 117.017 1.00 75.14  ? 345 LYS A N   1 
ATOM   2260 C CA  . LYS A 1 345 ? 126.009 104.389 118.288 1.00 81.71  ? 345 LYS A CA  1 
ATOM   2261 C C   . LYS A 1 345 ? 125.663 103.490 119.480 1.00 91.33  ? 345 LYS A C   1 
ATOM   2262 O O   . LYS A 1 345 ? 126.225 103.665 120.560 1.00 95.18  ? 345 LYS A O   1 
ATOM   2263 C CB  . LYS A 1 345 ? 125.191 105.682 118.378 1.00 84.15  ? 345 LYS A CB  1 
ATOM   2264 C CG  . LYS A 1 345 ? 125.882 106.939 117.864 1.00 103.00 ? 345 LYS A CG  1 
ATOM   2265 C CD  . LYS A 1 345 ? 125.974 107.030 116.360 1.00 107.80 ? 345 LYS A CD  1 
ATOM   2266 C CE  . LYS A 1 345 ? 126.674 108.288 115.894 1.00 129.24 ? 345 LYS A CE  1 
ATOM   2267 N NZ  . LYS A 1 345 ? 125.969 109.503 116.369 1.00 142.70 ? 345 LYS A NZ  1 
ATOM   2268 N N   . ALA A 1 346 ? 124.723 102.551 119.292 1.00 80.51  ? 346 ALA A N   1 
ATOM   2269 C CA  . ALA A 1 346 ? 124.316 101.615 120.326 1.00 71.03  ? 346 ALA A CA  1 
ATOM   2270 C C   . ALA A 1 346 ? 125.374 100.554 120.606 1.00 77.31  ? 346 ALA A C   1 
ATOM   2271 O O   . ALA A 1 346 ? 125.260 99.844  121.602 1.00 104.65 ? 346 ALA A O   1 
ATOM   2272 C CB  . ALA A 1 346 ? 123.014 100.971 119.914 1.00 79.36  ? 346 ALA A CB  1 
ATOM   2273 N N   . GLY A 1 347 ? 126.360 100.395 119.716 1.00 84.31  ? 347 GLY A N   1 
ATOM   2274 C CA  . GLY A 1 347 ? 127.481 99.492  119.946 1.00 85.87  ? 347 GLY A CA  1 
ATOM   2275 C C   . GLY A 1 347 ? 127.292 98.104  119.343 1.00 70.96  ? 347 GLY A C   1 
ATOM   2276 O O   . GLY A 1 347 ? 128.013 97.182  119.713 1.00 73.26  ? 347 GLY A O   1 
ATOM   2277 N N   . ILE A 1 348 ? 126.352 97.968  118.400 1.00 74.11  ? 348 ILE A N   1 
ATOM   2278 C CA  . ILE A 1 348 ? 126.183 96.727  117.647 1.00 76.83  ? 348 ILE A CA  1 
ATOM   2279 C C   . ILE A 1 348 ? 127.382 96.590  116.711 1.00 85.76  ? 348 ILE A C   1 
ATOM   2280 O O   . ILE A 1 348 ? 127.728 97.557  116.035 1.00 95.41  ? 348 ILE A O   1 
ATOM   2281 C CB  . ILE A 1 348 ? 124.853 96.717  116.866 1.00 81.19  ? 348 ILE A CB  1 
ATOM   2282 C CG1 . ILE A 1 348 ? 123.625 96.978  117.748 1.00 84.84  ? 348 ILE A CG1 1 
ATOM   2283 C CG2 . ILE A 1 348 ? 124.698 95.425  116.086 1.00 85.13  ? 348 ILE A CG2 1 
ATOM   2284 C CD1 . ILE A 1 348 ? 123.448 95.962  118.832 1.00 92.47  ? 348 ILE A CD1 1 
ATOM   2285 N N   . PRO A 1 349 ? 128.090 95.428  116.653 1.00 97.31  ? 349 PRO A N   1 
ATOM   2286 C CA  . PRO A 1 349 ? 129.276 95.284  115.801 1.00 97.31  ? 349 PRO A CA  1 
ATOM   2287 C C   . PRO A 1 349 ? 129.049 95.704  114.350 1.00 97.52  ? 349 PRO A C   1 
ATOM   2288 O O   . PRO A 1 349 ? 128.064 95.287  113.747 1.00 121.25 ? 349 PRO A O   1 
ATOM   2289 C CB  . PRO A 1 349 ? 129.592 93.785  115.890 1.00 93.65  ? 349 PRO A CB  1 
ATOM   2290 C CG  . PRO A 1 349 ? 129.099 93.403  117.269 1.00 103.78 ? 349 PRO A CG  1 
ATOM   2291 C CD  . PRO A 1 349 ? 127.835 94.217  117.450 1.00 101.24 ? 349 PRO A CD  1 
ATOM   2292 N N   . PRO A 1 350 ? 129.963 96.495  113.733 1.00 96.37  ? 350 PRO A N   1 
ATOM   2293 C CA  . PRO A 1 350 ? 129.745 97.062  112.397 1.00 102.75 ? 350 PRO A CA  1 
ATOM   2294 C C   . PRO A 1 350 ? 129.284 96.122  111.282 1.00 107.60 ? 350 PRO A C   1 
ATOM   2295 O O   . PRO A 1 350 ? 128.618 96.578  110.356 1.00 102.45 ? 350 PRO A O   1 
ATOM   2296 C CB  . PRO A 1 350 ? 131.128 97.624  112.043 1.00 127.86 ? 350 PRO A CB  1 
ATOM   2297 C CG  . PRO A 1 350 ? 131.708 98.021  113.379 1.00 137.77 ? 350 PRO A CG  1 
ATOM   2298 C CD  . PRO A 1 350 ? 131.234 96.939  114.326 1.00 118.87 ? 350 PRO A CD  1 
ATOM   2299 N N   . ALA A 1 351 ? 129.663 94.832  111.358 1.00 105.39 ? 351 ALA A N   1 
ATOM   2300 C CA  . ALA A 1 351 ? 129.356 93.842  110.334 1.00 95.78  ? 351 ALA A CA  1 
ATOM   2301 C C   . ALA A 1 351 ? 127.939 93.287  110.481 1.00 84.04  ? 351 ALA A C   1 
ATOM   2302 O O   . ALA A 1 351 ? 127.399 92.731  109.524 1.00 93.42  ? 351 ALA A O   1 
ATOM   2303 C CB  . ALA A 1 351 ? 130.383 92.742  110.402 1.00 111.43 ? 351 ALA A CB  1 
ATOM   2304 N N   . LYS A 1 352 ? 127.332 93.432  111.671 1.00 77.12  ? 352 LYS A N   1 
ATOM   2305 C CA  . LYS A 1 352 ? 126.023 92.867  111.968 1.00 74.74  ? 352 LYS A CA  1 
ATOM   2306 C C   . LYS A 1 352 ? 124.892 93.844  111.655 1.00 67.17  ? 352 LYS A C   1 
ATOM   2307 O O   . LYS A 1 352 ? 123.764 93.414  111.460 1.00 78.94  ? 352 LYS A O   1 
ATOM   2308 C CB  . LYS A 1 352 ? 125.920 92.451  113.436 1.00 79.80  ? 352 LYS A CB  1 
ATOM   2309 C CG  . LYS A 1 352 ? 126.803 91.269  113.812 1.00 107.99 ? 352 LYS A CG  1 
ATOM   2310 C CD  . LYS A 1 352 ? 126.563 90.763  115.214 1.00 134.97 ? 352 LYS A CD  1 
ATOM   2311 C CE  . LYS A 1 352 ? 127.545 89.680  115.611 1.00 160.29 ? 352 LYS A CE  1 
ATOM   2312 N NZ  . LYS A 1 352 ? 127.214 89.088  116.928 1.00 167.12 ? 352 LYS A NZ  1 
ATOM   2313 N N   . ILE A 1 353 ? 125.185 95.143  111.566 1.00 65.67  ? 353 ILE A N   1 
ATOM   2314 C CA  . ILE A 1 353 ? 124.143 96.161  111.568 1.00 68.49  ? 353 ILE A CA  1 
ATOM   2315 C C   . ILE A 1 353 ? 123.167 95.990  110.399 1.00 68.65  ? 353 ILE A C   1 
ATOM   2316 O O   . ILE A 1 353 ? 121.968 96.113  110.626 1.00 79.90  ? 353 ILE A O   1 
ATOM   2317 C CB  . ILE A 1 353 ? 124.748 97.583  111.634 1.00 66.25  ? 353 ILE A CB  1 
ATOM   2318 C CG1 . ILE A 1 353 ? 125.447 97.816  112.971 1.00 64.67  ? 353 ILE A CG1 1 
ATOM   2319 C CG2 . ILE A 1 353 ? 123.690 98.647  111.387 1.00 61.76  ? 353 ILE A CG2 1 
ATOM   2320 C CD1 . ILE A 1 353 ? 126.256 99.080  113.006 1.00 73.00  ? 353 ILE A CD1 1 
ATOM   2321 N N   . PRO A 1 354 ? 123.571 95.712  109.134 1.00 69.47  ? 354 PRO A N   1 
ATOM   2322 C CA  . PRO A 1 354 ? 122.605 95.609  108.040 1.00 76.39  ? 354 PRO A CA  1 
ATOM   2323 C C   . PRO A 1 354 ? 121.542 94.531  108.241 1.00 84.30  ? 354 PRO A C   1 
ATOM   2324 O O   . PRO A 1 354 ? 120.393 94.728  107.854 1.00 92.05  ? 354 PRO A O   1 
ATOM   2325 C CB  . PRO A 1 354 ? 123.463 95.304  106.804 1.00 84.03  ? 354 PRO A CB  1 
ATOM   2326 C CG  . PRO A 1 354 ? 124.829 95.850  107.161 1.00 94.49  ? 354 PRO A CG  1 
ATOM   2327 C CD  . PRO A 1 354 ? 124.946 95.588  108.647 1.00 80.89  ? 354 PRO A CD  1 
ATOM   2328 N N   . TYR A 1 355 ? 121.928 93.410  108.884 1.00 91.69  ? 355 TYR A N   1 
ATOM   2329 C CA  . TYR A 1 355 ? 121.061 92.267  109.152 1.00 73.14  ? 355 TYR A CA  1 
ATOM   2330 C C   . TYR A 1 355 ? 120.235 92.463  110.424 1.00 73.85  ? 355 TYR A C   1 
ATOM   2331 O O   . TYR A 1 355 ? 119.134 91.931  110.512 1.00 89.43  ? 355 TYR A O   1 
ATOM   2332 C CB  . TYR A 1 355 ? 121.933 91.023  109.297 1.00 65.91  ? 355 TYR A CB  1 
ATOM   2333 C CG  . TYR A 1 355 ? 122.894 90.829  108.140 1.00 75.26  ? 355 TYR A CG  1 
ATOM   2334 C CD1 . TYR A 1 355 ? 122.470 90.293  106.934 1.00 91.51  ? 355 TYR A CD1 1 
ATOM   2335 C CD2 . TYR A 1 355 ? 124.219 91.218  108.248 1.00 95.53  ? 355 TYR A CD2 1 
ATOM   2336 C CE1 . TYR A 1 355 ? 123.341 90.131  105.869 1.00 104.68 ? 355 TYR A CE1 1 
ATOM   2337 C CE2 . TYR A 1 355 ? 125.107 91.043  107.196 1.00 117.82 ? 355 TYR A CE2 1 
ATOM   2338 C CZ  . TYR A 1 355 ? 124.669 90.497  106.002 1.00 108.88 ? 355 TYR A CZ  1 
ATOM   2339 O OH  . TYR A 1 355 ? 125.542 90.303  104.965 1.00 112.70 ? 355 TYR A OH  1 
ATOM   2340 N N   . VAL A 1 356 ? 120.744 93.213  111.413 1.00 67.10  ? 356 VAL A N   1 
ATOM   2341 C CA  . VAL A 1 356 ? 119.999 93.544  112.621 1.00 61.15  ? 356 VAL A CA  1 
ATOM   2342 C C   . VAL A 1 356 ? 118.901 94.547  112.281 1.00 59.46  ? 356 VAL A C   1 
ATOM   2343 O O   . VAL A 1 356 ? 117.784 94.413  112.756 1.00 66.69  ? 356 VAL A O   1 
ATOM   2344 C CB  . VAL A 1 356 ? 120.940 94.041  113.736 1.00 67.76  ? 356 VAL A CB  1 
ATOM   2345 C CG1 . VAL A 1 356 ? 120.229 94.810  114.836 1.00 70.41  ? 356 VAL A CG1 1 
ATOM   2346 C CG2 . VAL A 1 356 ? 121.724 92.886  114.333 1.00 77.83  ? 356 VAL A CG2 1 
ATOM   2347 N N   . THR A 1 357 ? 119.192 95.543  111.442 1.00 59.95  ? 357 THR A N   1 
ATOM   2348 C CA  . THR A 1 357 ? 118.215 96.534  110.994 1.00 62.64  ? 357 THR A CA  1 
ATOM   2349 C C   . THR A 1 357 ? 117.013 95.886  110.304 1.00 67.78  ? 357 THR A C   1 
ATOM   2350 O O   . THR A 1 357 ? 115.894 96.359  110.458 1.00 67.29  ? 357 THR A O   1 
ATOM   2351 C CB  . THR A 1 357 ? 118.859 97.539  110.034 1.00 61.71  ? 357 THR A CB  1 
ATOM   2352 O OG1 . THR A 1 357 ? 119.732 98.371  110.804 1.00 61.10  ? 357 THR A OG1 1 
ATOM   2353 C CG2 . THR A 1 357 ? 117.877 98.383  109.253 1.00 57.77  ? 357 THR A CG2 1 
ATOM   2354 N N   . LEU A 1 358 ? 117.234 94.794  109.564 1.00 76.04  ? 358 LEU A N   1 
ATOM   2355 C CA  . LEU A 1 358 ? 116.193 94.097  108.815 1.00 71.78  ? 358 LEU A CA  1 
ATOM   2356 C C   . LEU A 1 358 ? 115.086 93.554  109.726 1.00 71.16  ? 358 LEU A C   1 
ATOM   2357 O O   . LEU A 1 358 ? 113.979 93.295  109.269 1.00 80.10  ? 358 LEU A O   1 
ATOM   2358 C CB  . LEU A 1 358 ? 116.881 92.986  108.017 1.00 62.80  ? 358 LEU A CB  1 
ATOM   2359 C CG  . LEU A 1 358 ? 116.021 92.198  107.051 1.00 70.99  ? 358 LEU A CG  1 
ATOM   2360 C CD1 . LEU A 1 358 ? 115.348 93.118  106.036 1.00 79.96  ? 358 LEU A CD1 1 
ATOM   2361 C CD2 . LEU A 1 358 ? 116.879 91.150  106.356 1.00 76.17  ? 358 LEU A CD2 1 
ATOM   2362 N N   . SER A 1 359 ? 115.351 93.422  111.030 1.00 69.16  ? 359 SER A N   1 
ATOM   2363 C CA  . SER A 1 359 ? 114.343 92.983  111.981 1.00 67.54  ? 359 SER A CA  1 
ATOM   2364 C C   . SER A 1 359 ? 113.337 94.091  112.296 1.00 60.01  ? 359 SER A C   1 
ATOM   2365 O O   . SER A 1 359 ? 112.240 93.785  112.770 1.00 72.54  ? 359 SER A O   1 
ATOM   2366 C CB  . SER A 1 359 ? 114.982 92.444  113.239 1.00 73.07  ? 359 SER A CB  1 
ATOM   2367 O OG  . SER A 1 359 ? 115.598 93.476  113.990 1.00 69.12  ? 359 SER A OG  1 
ATOM   2368 N N   . THR A 1 360 ? 113.684 95.359  112.032 1.00 54.34  ? 360 THR A N   1 
ATOM   2369 C CA  . THR A 1 360 ? 112.824 96.480  112.392 1.00 60.26  ? 360 THR A CA  1 
ATOM   2370 C C   . THR A 1 360 ? 111.634 96.593  111.429 1.00 62.71  ? 360 THR A C   1 
ATOM   2371 O O   . THR A 1 360 ? 110.522 96.861  111.880 1.00 77.12  ? 360 THR A O   1 
ATOM   2372 C CB  . THR A 1 360 ? 113.601 97.803  112.534 1.00 55.77  ? 360 THR A CB  1 
ATOM   2373 O OG1 . THR A 1 360 ? 114.152 98.180  111.276 1.00 61.57  ? 360 THR A OG1 1 
ATOM   2374 C CG2 . THR A 1 360 ? 114.705 97.741  113.568 1.00 55.63  ? 360 THR A CG2 1 
ATOM   2375 N N   . GLY A 1 361 ? 111.846 96.383  110.121 1.00 63.73  ? 361 GLY A N   1 
ATOM   2376 C CA  . GLY A 1 361 ? 110.767 96.274  109.147 1.00 61.32  ? 361 GLY A CA  1 
ATOM   2377 C C   . GLY A 1 361 ? 109.956 94.979  109.276 1.00 70.84  ? 361 GLY A C   1 
ATOM   2378 O O   . GLY A 1 361 ? 108.772 94.935  108.910 1.00 87.85  ? 361 GLY A O   1 
ATOM   2379 N N   . GLY A 1 362 ? 110.609 93.928  109.790 1.00 65.92  ? 362 GLY A N   1 
ATOM   2380 C CA  . GLY A 1 362 ? 109.959 92.656  110.061 1.00 73.56  ? 362 GLY A CA  1 
ATOM   2381 C C   . GLY A 1 362 ? 108.902 92.761  111.164 1.00 73.42  ? 362 GLY A C   1 
ATOM   2382 O O   . GLY A 1 362 ? 107.754 92.360  110.960 1.00 85.83  ? 362 GLY A O   1 
ATOM   2383 N N   . ILE A 1 363 ? 109.297 93.284  112.332 1.00 68.04  ? 363 ILE A N   1 
ATOM   2384 C CA  . ILE A 1 363 ? 108.392 93.452  113.460 1.00 67.90  ? 363 ILE A CA  1 
ATOM   2385 C C   . ILE A 1 363 ? 107.318 94.488  113.129 1.00 59.10  ? 363 ILE A C   1 
ATOM   2386 O O   . ILE A 1 363 ? 106.182 94.345  113.578 1.00 75.71  ? 363 ILE A O   1 
ATOM   2387 C CB  . ILE A 1 363 ? 109.166 93.717  114.781 1.00 73.26  ? 363 ILE A CB  1 
ATOM   2388 C CG1 . ILE A 1 363 ? 109.364 92.418  115.567 1.00 79.16  ? 363 ILE A CG1 1 
ATOM   2389 C CG2 . ILE A 1 363 ? 108.493 94.741  115.665 1.00 72.91  ? 363 ILE A CG2 1 
ATOM   2390 C CD1 . ILE A 1 363 ? 110.199 91.374  114.821 1.00 103.10 ? 363 ILE A CD1 1 
ATOM   2391 N N   . GLU A 1 364 ? 107.626 95.524  112.351 1.00 59.36  ? 364 GLU A N   1 
ATOM   2392 C CA  . GLU A 1 364 ? 106.595 96.465  111.935 1.00 65.91  ? 364 GLU A CA  1 
ATOM   2393 C C   . GLU A 1 364 ? 105.523 95.754  111.101 1.00 75.57  ? 364 GLU A C   1 
ATOM   2394 O O   . GLU A 1 364 ? 104.333 95.960  111.319 1.00 81.66  ? 364 GLU A O   1 
ATOM   2395 C CB  . GLU A 1 364 ? 107.172 97.634  111.137 1.00 72.65  ? 364 GLU A CB  1 
ATOM   2396 C CG  . GLU A 1 364 ? 106.202 98.791  111.035 1.00 94.20  ? 364 GLU A CG  1 
ATOM   2397 C CD  . GLU A 1 364 ? 106.386 99.714  109.844 1.00 118.39 ? 364 GLU A CD  1 
ATOM   2398 O OE1 . GLU A 1 364 ? 106.791 99.212  108.777 1.00 112.76 ? 364 GLU A OE1 1 
ATOM   2399 O OE2 . GLU A 1 364 ? 106.072 100.926 109.977 1.00 141.74 ? 364 GLU A OE2 1 
ATOM   2400 N N   . THR A 1 365 ? 105.935 94.897  110.154 1.00 90.05  ? 365 THR A N   1 
ATOM   2401 C CA  . THR A 1 365 ? 104.990 94.161  109.324 1.00 81.92  ? 365 THR A CA  1 
ATOM   2402 C C   . THR A 1 365 ? 104.162 93.173  110.156 1.00 70.92  ? 365 THR A C   1 
ATOM   2403 O O   . THR A 1 365 ? 102.968 93.043  109.922 1.00 75.66  ? 365 THR A O   1 
ATOM   2404 C CB  . THR A 1 365 ? 105.691 93.444  108.162 1.00 80.19  ? 365 THR A CB  1 
ATOM   2405 O OG1 . THR A 1 365 ? 106.441 94.404  107.414 1.00 75.25  ? 365 THR A OG1 1 
ATOM   2406 C CG2 . THR A 1 365 ? 104.707 92.766  107.234 1.00 84.56  ? 365 THR A CG2 1 
ATOM   2407 N N   . LEU A 1 366 ? 104.772 92.461  111.113 1.00 65.67  ? 366 LEU A N   1 
ATOM   2408 C CA  . LEU A 1 366 ? 104.032 91.582  112.010 1.00 71.66  ? 366 LEU A CA  1 
ATOM   2409 C C   . LEU A 1 366 ? 102.977 92.364  112.787 1.00 68.19  ? 366 LEU A C   1 
ATOM   2410 O O   . LEU A 1 366 ? 101.832 91.924  112.887 1.00 80.15  ? 366 LEU A O   1 
ATOM   2411 C CB  . LEU A 1 366 ? 104.991 90.889  112.987 1.00 75.34  ? 366 LEU A CB  1 
ATOM   2412 C CG  . LEU A 1 366 ? 105.418 89.487  112.604 1.00 88.42  ? 366 LEU A CG  1 
ATOM   2413 C CD1 . LEU A 1 366 ? 106.629 89.058  113.408 1.00 110.11 ? 366 LEU A CD1 1 
ATOM   2414 C CD2 . LEU A 1 366 ? 104.283 88.516  112.836 1.00 90.65  ? 366 LEU A CD2 1 
ATOM   2415 N N   . ALA A 1 367 ? 103.375 93.496  113.372 1.00 69.15  ? 367 ALA A N   1 
ATOM   2416 C CA  . ALA A 1 367 ? 102.497 94.295  114.201 1.00 72.01  ? 367 ALA A CA  1 
ATOM   2417 C C   . ALA A 1 367 ? 101.377 94.929  113.378 1.00 70.18  ? 367 ALA A C   1 
ATOM   2418 O O   . ALA A 1 367 ? 100.263 95.044  113.885 1.00 104.36 ? 367 ALA A O   1 
ATOM   2419 C CB  . ALA A 1 367 ? 103.320 95.333  114.935 1.00 93.47  ? 367 ALA A CB  1 
ATOM   2420 N N   . ALA A 1 368 ? 101.639 95.296  112.119 1.00 74.76  ? 368 ALA A N   1 
ATOM   2421 C CA  . ALA A 1 368 ? 100.631 95.865  111.229 1.00 79.11  ? 368 ALA A CA  1 
ATOM   2422 C C   . ALA A 1 368 ? 99.568  94.837  110.825 1.00 73.67  ? 368 ALA A C   1 
ATOM   2423 O O   . ALA A 1 368 ? 98.414  95.213  110.627 1.00 89.93  ? 368 ALA A O   1 
ATOM   2424 C CB  . ALA A 1 368 ? 101.298 96.468  109.998 1.00 79.92  ? 368 ALA A CB  1 
ATOM   2425 N N   . VAL A 1 369 ? 99.940  93.559  110.684 1.00 74.24  ? 369 VAL A N   1 
ATOM   2426 C CA  . VAL A 1 369 ? 99.016  92.496  110.305 1.00 75.63  ? 369 VAL A CA  1 
ATOM   2427 C C   . VAL A 1 369 ? 98.027  92.211  111.440 1.00 74.08  ? 369 VAL A C   1 
ATOM   2428 O O   . VAL A 1 369 ? 96.844  92.001  111.178 1.00 89.78  ? 369 VAL A O   1 
ATOM   2429 C CB  . VAL A 1 369 ? 99.785  91.232  109.857 1.00 75.03  ? 369 VAL A CB  1 
ATOM   2430 C CG1 . VAL A 1 369 ? 98.947  89.965  109.878 1.00 79.70  ? 369 VAL A CG1 1 
ATOM   2431 C CG2 . VAL A 1 369 ? 100.395 91.427  108.484 1.00 86.45  ? 369 VAL A CG2 1 
ATOM   2432 N N   . PHE A 1 370 ? 98.489  92.218  112.696 1.00 79.46  ? 370 PHE A N   1 
ATOM   2433 C CA  . PHE A 1 370 ? 97.620  91.966  113.837 1.00 91.01  ? 370 PHE A CA  1 
ATOM   2434 C C   . PHE A 1 370 ? 96.978  93.246  114.380 1.00 91.00  ? 370 PHE A C   1 
ATOM   2435 O O   . PHE A 1 370 ? 96.162  93.156  115.286 1.00 98.65  ? 370 PHE A O   1 
ATOM   2436 C CB  . PHE A 1 370 ? 98.387  91.223  114.936 1.00 99.17  ? 370 PHE A CB  1 
ATOM   2437 C CG  . PHE A 1 370 ? 98.824  89.833  114.540 1.00 116.97 ? 370 PHE A CG  1 
ATOM   2438 C CD1 . PHE A 1 370 ? 97.885  88.865  114.231 1.00 134.95 ? 370 PHE A CD1 1 
ATOM   2439 C CD2 . PHE A 1 370 ? 100.164 89.498  114.451 1.00 144.30 ? 370 PHE A CD2 1 
ATOM   2440 C CE1 . PHE A 1 370 ? 98.271  87.587  113.861 1.00 149.36 ? 370 PHE A CE1 1 
ATOM   2441 C CE2 . PHE A 1 370 ? 100.548 88.221  114.081 1.00 162.42 ? 370 PHE A CE2 1 
ATOM   2442 C CZ  . PHE A 1 370 ? 99.603  87.268  113.785 1.00 166.66 ? 370 PHE A CZ  1 
ATOM   2443 N N   . SER A 1 371 ? 97.287  94.413  113.799 1.00 96.40  ? 371 SER A N   1 
ATOM   2444 C CA  . SER A 1 371 ? 96.760  95.708  114.227 1.00 96.81  ? 371 SER A CA  1 
ATOM   2445 C C   . SER A 1 371 ? 95.232  95.714  114.254 1.00 98.93  ? 371 SER A C   1 
ATOM   2446 O O   . SER A 1 371 ? 94.627  96.255  115.175 1.00 109.47 ? 371 SER A O   1 
ATOM   2447 C CB  . SER A 1 371 ? 97.288  96.810  113.324 1.00 104.18 ? 371 SER A CB  1 
ATOM   2448 O OG  . SER A 1 371 ? 97.019  98.094  113.862 1.00 128.83 ? 371 SER A OG  1 
ATOM   2449 N N   . GLY A 1 372 ? 94.608  95.080  113.257 1.00 109.52 ? 372 GLY A N   1 
ATOM   2450 C CA  . GLY A 1 372 ? 93.156  95.016  113.159 1.00 110.98 ? 372 GLY A CA  1 
ATOM   2451 C C   . GLY A 1 372 ? 92.479  94.238  114.291 1.00 103.09 ? 372 GLY A C   1 
ATOM   2452 O O   . GLY A 1 372 ? 91.303  94.451  114.539 1.00 103.54 ? 372 GLY A O   1 
ATOM   2453 N N   . LEU A 1 373 ? 93.193  93.320  114.951 1.00 103.04 ? 373 LEU A N   1 
ATOM   2454 C CA  . LEU A 1 373 ? 92.619  92.523  116.027 1.00 105.72 ? 373 LEU A CA  1 
ATOM   2455 C C   . LEU A 1 373 ? 92.629  93.277  117.355 1.00 98.77  ? 373 LEU A C   1 
ATOM   2456 O O   . LEU A 1 373 ? 91.926  92.876  118.281 1.00 124.35 ? 373 LEU A O   1 
ATOM   2457 C CB  . LEU A 1 373 ? 93.415  91.217  116.183 1.00 116.57 ? 373 LEU A CB  1 
ATOM   2458 C CG  . LEU A 1 373 ? 93.366  90.249  115.014 1.00 113.78 ? 373 LEU A CG  1 
ATOM   2459 C CD1 . LEU A 1 373 ? 94.079  88.959  115.387 1.00 122.31 ? 373 LEU A CD1 1 
ATOM   2460 C CD2 . LEU A 1 373 ? 91.922  89.978  114.626 1.00 130.81 ? 373 LEU A CD2 1 
ATOM   2461 N N   . VAL A 1 374 ? 93.454  94.325  117.469 1.00 84.11  ? 374 VAL A N   1 
ATOM   2462 C CA  . VAL A 1 374 ? 93.583  95.070  118.713 1.00 81.58  ? 374 VAL A CA  1 
ATOM   2463 C C   . VAL A 1 374 ? 92.605  96.248  118.689 1.00 80.54  ? 374 VAL A C   1 
ATOM   2464 O O   . VAL A 1 374 ? 91.952  96.526  119.684 1.00 102.70 ? 374 VAL A O   1 
ATOM   2465 C CB  . VAL A 1 374 ? 95.032  95.542  118.955 1.00 82.53  ? 374 VAL A CB  1 
ATOM   2466 C CG1 . VAL A 1 374 ? 95.219  96.008  120.377 1.00 92.78  ? 374 VAL A CG1 1 
ATOM   2467 C CG2 . VAL A 1 374 ? 96.057  94.466  118.656 1.00 92.72  ? 374 VAL A CG2 1 
ATOM   2468 N N   . ILE A 1 375 ? 92.483  96.922  117.541 1.00 78.97  ? 375 ILE A N   1 
ATOM   2469 C CA  . ILE A 1 375 ? 91.690  98.134  117.401 1.00 79.48  ? 375 ILE A CA  1 
ATOM   2470 C C   . ILE A 1 375 ? 90.188  97.858  117.522 1.00 92.47  ? 375 ILE A C   1 
ATOM   2471 O O   . ILE A 1 375 ? 89.435  98.765  117.883 1.00 115.52 ? 375 ILE A O   1 
ATOM   2472 C CB  . ILE A 1 375 ? 92.063  98.835  116.076 1.00 92.92  ? 375 ILE A CB  1 
ATOM   2473 C CG1 . ILE A 1 375 ? 91.590  100.280 116.014 1.00 100.58 ? 375 ILE A CG1 1 
ATOM   2474 C CG2 . ILE A 1 375 ? 91.563  98.052  114.866 1.00 131.48 ? 375 ILE A CG2 1 
ATOM   2475 C CD1 . ILE A 1 375 ? 92.335  101.073 114.951 1.00 121.11 ? 375 ILE A CD1 1 
ATOM   2476 N N   . GLU A 1 376 ? 89.751  96.617  117.256 1.00 103.96 ? 376 GLU A N   1 
ATOM   2477 C CA  . GLU A 1 376 ? 88.354  96.223  117.392 1.00 111.47 ? 376 GLU A CA  1 
ATOM   2478 C C   . GLU A 1 376 ? 87.997  95.878  118.838 1.00 98.48  ? 376 GLU A C   1 
ATOM   2479 O O   . GLU A 1 376 ? 86.813  95.880  119.185 1.00 129.19 ? 376 GLU A O   1 
ATOM   2480 C CB  . GLU A 1 376 ? 88.027  95.033  116.489 1.00 142.20 ? 376 GLU A CB  1 
ATOM   2481 C CG  . GLU A 1 376 ? 87.979  95.387  115.009 1.00 185.55 ? 376 GLU A CG  1 
ATOM   2482 C CD  . GLU A 1 376 ? 87.562  94.253  114.082 1.00 218.05 ? 376 GLU A CD  1 
ATOM   2483 O OE1 . GLU A 1 376 ? 87.333  93.128  114.579 1.00 225.01 ? 376 GLU A OE1 1 
ATOM   2484 O OE2 . GLU A 1 376 ? 87.463  94.497  112.861 1.00 228.19 ? 376 GLU A OE2 1 
ATOM   2485 N N   . HIS A 1 377 ? 88.995  95.607  119.689 1.00 94.83  ? 377 HIS A N   1 
ATOM   2486 C CA  . HIS A 1 377 ? 88.754  95.095  121.034 1.00 123.44 ? 377 HIS A CA  1 
ATOM   2487 C C   . HIS A 1 377 ? 88.819  96.188  122.107 1.00 113.54 ? 377 HIS A C   1 
ATOM   2488 O O   . HIS A 1 377 ? 87.921  96.270  122.943 1.00 127.69 ? 377 HIS A O   1 
ATOM   2489 C CB  . HIS A 1 377 ? 89.686  93.913  121.327 1.00 138.41 ? 377 HIS A CB  1 
ATOM   2490 C CG  . HIS A 1 377 ? 89.177  92.618  120.770 1.00 172.01 ? 377 HIS A CG  1 
ATOM   2491 N ND1 . HIS A 1 377 ? 88.691  92.476  119.486 1.00 175.54 ? 377 HIS A ND1 1 
ATOM   2492 C CD2 . HIS A 1 377 ? 89.034  91.415  121.349 1.00 196.84 ? 377 HIS A CD2 1 
ATOM   2493 C CE1 . HIS A 1 377 ? 88.299  91.228  119.298 1.00 192.92 ? 377 HIS A CE1 1 
ATOM   2494 N NE2 . HIS A 1 377 ? 88.498  90.565  120.417 1.00 200.80 ? 377 HIS A NE2 1 
ATOM   2495 N N   . LEU A 1 378 ? 89.862  97.026  122.094 1.00 99.33  ? 378 LEU A N   1 
ATOM   2496 C CA  . LEU A 1 378 ? 90.160  97.882  123.232 1.00 112.08 ? 378 LEU A CA  1 
ATOM   2497 C C   . LEU A 1 378 ? 89.390  99.206  123.182 1.00 122.03 ? 378 LEU A C   1 
ATOM   2498 O O   . LEU A 1 378 ? 89.095  99.779  124.238 1.00 129.49 ? 378 LEU A O   1 
ATOM   2499 C CB  . LEU A 1 378 ? 91.674  98.130  123.292 1.00 106.80 ? 378 LEU A CB  1 
ATOM   2500 C CG  . LEU A 1 378 ? 92.492  97.007  123.909 1.00 108.41 ? 378 LEU A CG  1 
ATOM   2501 C CD1 . LEU A 1 378 ? 93.971  97.285  123.748 1.00 117.35 ? 378 LEU A CD1 1 
ATOM   2502 C CD2 . LEU A 1 378 ? 92.128  96.857  125.384 1.00 114.31 ? 378 LEU A CD2 1 
ATOM   2503 N N   . GLY A 1 379 ? 89.104  99.715  121.979 1.00 104.81 ? 379 GLY A N   1 
ATOM   2504 C CA  . GLY A 1 379 ? 88.540  101.053 121.865 1.00 121.78 ? 379 GLY A CA  1 
ATOM   2505 C C   . GLY A 1 379 ? 89.636  102.117 121.847 1.00 110.21 ? 379 GLY A C   1 
ATOM   2506 O O   . GLY A 1 379 ? 90.762  101.854 122.253 1.00 120.75 ? 379 GLY A O   1 
ATOM   2507 N N   . ARG A 1 380 ? 89.295  103.335 121.402 1.00 105.47 ? 380 ARG A N   1 
ATOM   2508 C CA  . ARG A 1 380 ? 90.288  104.277 120.911 1.00 92.56  ? 380 ARG A CA  1 
ATOM   2509 C C   . ARG A 1 380 ? 91.087  104.878 122.064 1.00 86.84  ? 380 ARG A C   1 
ATOM   2510 O O   . ARG A 1 380 ? 92.291  105.086 121.938 1.00 92.08  ? 380 ARG A O   1 
ATOM   2511 C CB  . ARG A 1 380 ? 89.648  105.383 120.063 1.00 91.03  ? 380 ARG A CB  1 
ATOM   2512 C CG  . ARG A 1 380 ? 89.222  104.953 118.665 1.00 93.80  ? 380 ARG A CG  1 
ATOM   2513 C CD  . ARG A 1 380 ? 87.929  104.156 118.610 1.00 88.40  ? 380 ARG A CD  1 
ATOM   2514 N NE  . ARG A 1 380 ? 87.321  104.172 117.285 1.00 100.80 ? 380 ARG A NE  1 
ATOM   2515 C CZ  . ARG A 1 380 ? 87.264  103.140 116.453 1.00 126.30 ? 380 ARG A CZ  1 
ATOM   2516 N NH1 . ARG A 1 380 ? 86.581  103.238 115.324 1.00 136.36 ? 380 ARG A NH1 1 
ATOM   2517 N NH2 . ARG A 1 380 ? 87.865  102.004 116.759 1.00 145.61 ? 380 ARG A NH2 1 
ATOM   2518 N N   . ARG A 1 381 ? 90.433  105.178 123.190 1.00 84.42  ? 381 ARG A N   1 
ATOM   2519 C CA  . ARG A 1 381 ? 91.068  105.954 124.253 1.00 73.69  ? 381 ARG A CA  1 
ATOM   2520 C C   . ARG A 1 381 ? 92.211  105.180 124.920 1.00 74.37  ? 381 ARG A C   1 
ATOM   2521 O O   . ARG A 1 381 ? 93.315  105.709 124.971 1.00 86.39  ? 381 ARG A O   1 
ATOM   2522 C CB  . ARG A 1 381 ? 89.992  106.442 125.229 1.00 67.68  ? 381 ARG A CB  1 
ATOM   2523 C CG  . ARG A 1 381 ? 90.524  107.308 126.351 1.00 62.01  ? 381 ARG A CG  1 
ATOM   2524 C CD  . ARG A 1 381 ? 89.416  107.880 127.200 1.00 63.61  ? 381 ARG A CD  1 
ATOM   2525 N NE  . ARG A 1 381 ? 89.840  108.080 128.577 1.00 68.37  ? 381 ARG A NE  1 
ATOM   2526 C CZ  . ARG A 1 381 ? 90.315  109.214 129.057 1.00 75.60  ? 381 ARG A CZ  1 
ATOM   2527 N NH1 . ARG A 1 381 ? 90.577  109.325 130.347 1.00 107.32 ? 381 ARG A NH1 1 
ATOM   2528 N NH2 . ARG A 1 381 ? 90.473  110.255 128.265 1.00 68.77  ? 381 ARG A NH2 1 
ATOM   2529 N N   . PRO A 1 382 ? 92.056  103.937 125.460 1.00 84.31  ? 382 PRO A N   1 
ATOM   2530 C CA  . PRO A 1 382 ? 93.189  103.216 126.042 1.00 73.87  ? 382 PRO A CA  1 
ATOM   2531 C C   . PRO A 1 382 ? 94.266  102.726 125.073 1.00 62.01  ? 382 PRO A C   1 
ATOM   2532 O O   . PRO A 1 382 ? 95.401  102.544 125.505 1.00 66.99  ? 382 PRO A O   1 
ATOM   2533 C CB  . PRO A 1 382 ? 92.544  102.044 126.787 1.00 78.30  ? 382 PRO A CB  1 
ATOM   2534 C CG  . PRO A 1 382 ? 91.251  101.808 126.063 1.00 90.39  ? 382 PRO A CG  1 
ATOM   2535 C CD  . PRO A 1 382 ? 90.804  103.183 125.619 1.00 105.29 ? 382 PRO A CD  1 
ATOM   2536 N N   . LEU A 1 383 ? 93.949  102.547 123.783 1.00 60.00  ? 383 LEU A N   1 
ATOM   2537 C CA  . LEU A 1 383 ? 94.963  102.239 122.781 1.00 67.68  ? 383 LEU A CA  1 
ATOM   2538 C C   . LEU A 1 383 ? 95.850  103.440 122.473 1.00 71.50  ? 383 LEU A C   1 
ATOM   2539 O O   . LEU A 1 383 ? 97.052  103.281 122.306 1.00 86.41  ? 383 LEU A O   1 
ATOM   2540 C CB  . LEU A 1 383 ? 94.332  101.742 121.481 1.00 75.34  ? 383 LEU A CB  1 
ATOM   2541 C CG  . LEU A 1 383 ? 94.259  100.227 121.315 1.00 94.43  ? 383 LEU A CG  1 
ATOM   2542 C CD1 . LEU A 1 383 ? 93.627  99.874  119.988 1.00 95.92  ? 383 LEU A CD1 1 
ATOM   2543 C CD2 . LEU A 1 383 ? 95.630  99.586  121.409 1.00 107.26 ? 383 LEU A CD2 1 
ATOM   2544 N N   . LEU A 1 384 ? 95.268  104.632 122.360 1.00 87.94  ? 384 LEU A N   1 
ATOM   2545 C CA  . LEU A 1 384 ? 96.044  105.807 121.990 1.00 84.54  ? 384 LEU A CA  1 
ATOM   2546 C C   . LEU A 1 384 ? 96.864  106.302 123.182 1.00 68.53  ? 384 LEU A C   1 
ATOM   2547 O O   . LEU A 1 384 ? 98.038  106.598 123.007 1.00 73.74  ? 384 LEU A O   1 
ATOM   2548 C CB  . LEU A 1 384 ? 95.097  106.875 121.431 1.00 84.76  ? 384 LEU A CB  1 
ATOM   2549 C CG  . LEU A 1 384 ? 95.742  107.983 120.612 1.00 90.73  ? 384 LEU A CG  1 
ATOM   2550 C CD1 . LEU A 1 384 ? 96.543  107.438 119.441 1.00 90.23  ? 384 LEU A CD1 1 
ATOM   2551 C CD2 . LEU A 1 384 ? 94.673  108.930 120.107 1.00 99.76  ? 384 LEU A CD2 1 
ATOM   2552 N N   . ILE A 1 385 ? 96.289  106.323 124.393 1.00 61.96  ? 385 ILE A N   1 
ATOM   2553 C CA  . ILE A 1 385 ? 97.011  106.753 125.587 1.00 60.13  ? 385 ILE A CA  1 
ATOM   2554 C C   . ILE A 1 385 ? 98.094  105.736 125.939 1.00 69.71  ? 385 ILE A C   1 
ATOM   2555 O O   . ILE A 1 385 ? 99.242  106.105 126.161 1.00 62.87  ? 385 ILE A O   1 
ATOM   2556 C CB  . ILE A 1 385 ? 96.062  106.997 126.782 1.00 58.60  ? 385 ILE A CB  1 
ATOM   2557 C CG1 . ILE A 1 385 ? 95.032  108.086 126.483 1.00 77.09  ? 385 ILE A CG1 1 
ATOM   2558 C CG2 . ILE A 1 385 ? 96.850  107.363 128.021 1.00 61.01  ? 385 ILE A CG2 1 
ATOM   2559 C CD1 . ILE A 1 385 ? 93.857  108.047 127.405 1.00 88.16  ? 385 ILE A CD1 1 
ATOM   2560 N N   . GLY A 1 386 ? 97.724  104.453 126.015 1.00 83.69  ? 386 GLY A N   1 
ATOM   2561 C CA  . GLY A 1 386 ? 98.666  103.400 126.360 1.00 80.67  ? 386 GLY A CA  1 
ATOM   2562 C C   . GLY A 1 386 ? 99.698  103.129 125.264 1.00 72.48  ? 386 GLY A C   1 
ATOM   2563 O O   . GLY A 1 386 ? 100.750 102.561 125.549 1.00 91.39  ? 386 GLY A O   1 
ATOM   2564 N N   . GLY A 1 387 ? 99.403  103.523 124.021 1.00 71.46  ? 387 GLY A N   1 
ATOM   2565 C CA  . GLY A 1 387 ? 100.363 103.443 122.928 1.00 67.29  ? 387 GLY A CA  1 
ATOM   2566 C C   . GLY A 1 387 ? 101.504 104.447 123.078 1.00 70.39  ? 387 GLY A C   1 
ATOM   2567 O O   . GLY A 1 387 ? 102.658 104.046 123.116 1.00 93.07  ? 387 GLY A O   1 
ATOM   2568 N N   . PHE A 1 388 ? 101.183 105.742 123.186 1.00 67.44  ? 388 PHE A N   1 
ATOM   2569 C CA  . PHE A 1 388 ? 102.183 106.767 123.432 1.00 67.88  ? 388 PHE A CA  1 
ATOM   2570 C C   . PHE A 1 388 ? 102.836 106.555 124.800 1.00 63.17  ? 388 PHE A C   1 
ATOM   2571 O O   . PHE A 1 388 ? 104.044 106.731 124.942 1.00 85.29  ? 388 PHE A O   1 
ATOM   2572 C CB  . PHE A 1 388 ? 101.585 108.176 123.321 1.00 69.66  ? 388 PHE A CB  1 
ATOM   2573 C CG  . PHE A 1 388 ? 101.174 108.600 121.936 1.00 81.40  ? 388 PHE A CG  1 
ATOM   2574 C CD1 . PHE A 1 388 ? 102.074 108.558 120.887 1.00 94.09  ? 388 PHE A CD1 1 
ATOM   2575 C CD2 . PHE A 1 388 ? 99.890  109.053 121.680 1.00 96.62  ? 388 PHE A CD2 1 
ATOM   2576 C CE1 . PHE A 1 388 ? 101.692 108.950 119.611 1.00 119.16 ? 388 PHE A CE1 1 
ATOM   2577 C CE2 . PHE A 1 388 ? 99.506  109.430 120.400 1.00 110.02 ? 388 PHE A CE2 1 
ATOM   2578 C CZ  . PHE A 1 388 ? 100.415 109.399 119.368 1.00 109.29 ? 388 PHE A CZ  1 
ATOM   2579 N N   . GLY A 1 389 ? 102.050 106.187 125.811 1.00 60.50  ? 389 GLY A N   1 
ATOM   2580 C CA  . GLY A 1 389 ? 102.582 105.936 127.141 1.00 72.65  ? 389 GLY A CA  1 
ATOM   2581 C C   . GLY A 1 389 ? 103.670 104.859 127.189 1.00 71.20  ? 389 GLY A C   1 
ATOM   2582 O O   . GLY A 1 389 ? 104.625 105.006 127.953 1.00 80.30  ? 389 GLY A O   1 
ATOM   2583 N N   . LEU A 1 390 ? 103.515 103.780 126.404 1.00 68.12  ? 390 LEU A N   1 
ATOM   2584 C CA  . LEU A 1 390 ? 104.498 102.714 126.337 1.00 65.17  ? 390 LEU A CA  1 
ATOM   2585 C C   . LEU A 1 390 ? 105.720 103.149 125.535 1.00 65.26  ? 390 LEU A C   1 
ATOM   2586 O O   . LEU A 1 390 ? 106.833 102.836 125.945 1.00 85.43  ? 390 LEU A O   1 
ATOM   2587 C CB  . LEU A 1 390 ? 103.879 101.447 125.726 1.00 65.11  ? 390 LEU A CB  1 
ATOM   2588 C CG  . LEU A 1 390 ? 103.044 100.601 126.674 1.00 72.97  ? 390 LEU A CG  1 
ATOM   2589 C CD1 . LEU A 1 390 ? 102.380 99.477  125.911 1.00 87.91  ? 390 LEU A CD1 1 
ATOM   2590 C CD2 . LEU A 1 390 ? 103.889 100.040 127.799 1.00 83.23  ? 390 LEU A CD2 1 
ATOM   2591 N N   . MET A 1 391 ? 105.552 103.844 124.406 1.00 63.85  ? 391 MET A N   1 
ATOM   2592 C CA  . MET A 1 391 ? 106.704 104.311 123.654 1.00 79.19  ? 391 MET A CA  1 
ATOM   2593 C C   . MET A 1 391 ? 107.575 105.229 124.528 1.00 82.93  ? 391 MET A C   1 
ATOM   2594 O O   . MET A 1 391 ? 108.798 105.131 124.512 1.00 86.75  ? 391 MET A O   1 
ATOM   2595 C CB  . MET A 1 391 ? 106.261 105.063 122.398 1.00 77.96  ? 391 MET A CB  1 
ATOM   2596 C CG  . MET A 1 391 ? 105.657 104.170 121.363 1.00 86.81  ? 391 MET A CG  1 
ATOM   2597 S SD  . MET A 1 391 ? 104.927 105.133 120.021 1.00 109.54 ? 391 MET A SD  1 
ATOM   2598 C CE  . MET A 1 391 ? 106.429 105.651 119.197 1.00 108.40 ? 391 MET A CE  1 
ATOM   2599 N N   . GLY A 1 392 ? 106.951 106.125 125.290 1.00 81.60  ? 392 GLY A N   1 
ATOM   2600 C CA  . GLY A 1 392 ? 107.669 106.955 126.235 1.00 74.69  ? 392 GLY A CA  1 
ATOM   2601 C C   . GLY A 1 392 ? 108.448 106.168 127.290 1.00 73.60  ? 392 GLY A C   1 
ATOM   2602 O O   . GLY A 1 392 ? 109.434 106.662 127.809 1.00 95.16  ? 392 GLY A O   1 
ATOM   2603 N N   . LEU A 1 393 ? 107.987 104.972 127.669 1.00 71.29  ? 393 LEU A N   1 
ATOM   2604 C CA  . LEU A 1 393 ? 108.714 104.108 128.590 1.00 74.35  ? 393 LEU A CA  1 
ATOM   2605 C C   . LEU A 1 393 ? 109.908 103.455 127.889 1.00 78.06  ? 393 LEU A C   1 
ATOM   2606 O O   . LEU A 1 393 ? 110.994 103.427 128.455 1.00 92.14  ? 393 LEU A O   1 
ATOM   2607 C CB  . LEU A 1 393 ? 107.757 103.052 129.163 1.00 80.81  ? 393 LEU A CB  1 
ATOM   2608 C CG  . LEU A 1 393 ? 108.393 101.870 129.888 1.00 85.69  ? 393 LEU A CG  1 
ATOM   2609 C CD1 . LEU A 1 393 ? 109.040 102.332 131.177 1.00 105.24 ? 393 LEU A CD1 1 
ATOM   2610 C CD2 . LEU A 1 393 ? 107.369 100.785 130.151 1.00 92.57  ? 393 LEU A CD2 1 
ATOM   2611 N N   . PHE A 1 394 ? 109.731 102.962 126.653 1.00 73.17  ? 394 PHE A N   1 
ATOM   2612 C CA  . PHE A 1 394 ? 110.789 102.250 125.950 1.00 76.34  ? 394 PHE A CA  1 
ATOM   2613 C C   . PHE A 1 394 ? 111.865 103.193 125.382 1.00 83.25  ? 394 PHE A C   1 
ATOM   2614 O O   . PHE A 1 394 ? 113.012 102.775 125.253 1.00 97.96  ? 394 PHE A O   1 
ATOM   2615 C CB  . PHE A 1 394 ? 110.194 101.334 124.879 1.00 81.27  ? 394 PHE A CB  1 
ATOM   2616 C CG  . PHE A 1 394 ? 109.343 100.215 125.429 1.00 82.30  ? 394 PHE A CG  1 
ATOM   2617 C CD1 . PHE A 1 394 ? 109.862 99.335  126.363 1.00 80.27  ? 394 PHE A CD1 1 
ATOM   2618 C CD2 . PHE A 1 394 ? 108.030 100.045 125.011 1.00 85.08  ? 394 PHE A CD2 1 
ATOM   2619 C CE1 . PHE A 1 394 ? 109.091 98.311  126.875 1.00 79.46  ? 394 PHE A CE1 1 
ATOM   2620 C CE2 . PHE A 1 394 ? 107.257 99.024  125.526 1.00 84.07  ? 394 PHE A CE2 1 
ATOM   2621 C CZ  . PHE A 1 394 ? 107.793 98.165  126.458 1.00 93.05  ? 394 PHE A CZ  1 
ATOM   2622 N N   . PHE A 1 395 ? 111.549 104.456 125.068 1.00 74.22  ? 395 PHE A N   1 
ATOM   2623 C CA  . PHE A 1 395 ? 112.576 105.461 124.820 1.00 60.89  ? 395 PHE A CA  1 
ATOM   2624 C C   . PHE A 1 395 ? 113.367 105.768 126.096 1.00 70.36  ? 395 PHE A C   1 
ATOM   2625 O O   . PHE A 1 395 ? 114.516 106.208 126.020 1.00 108.65 ? 395 PHE A O   1 
ATOM   2626 C CB  . PHE A 1 395 ? 111.974 106.758 124.265 1.00 58.70  ? 395 PHE A CB  1 
ATOM   2627 C CG  . PHE A 1 395 ? 111.555 106.712 122.816 1.00 59.20  ? 395 PHE A CG  1 
ATOM   2628 C CD1 . PHE A 1 395 ? 112.432 106.297 121.831 1.00 61.67  ? 395 PHE A CD1 1 
ATOM   2629 C CD2 . PHE A 1 395 ? 110.288 107.129 122.434 1.00 66.14  ? 395 PHE A CD2 1 
ATOM   2630 C CE1 . PHE A 1 395 ? 112.052 106.292 120.497 1.00 71.82  ? 395 PHE A CE1 1 
ATOM   2631 C CE2 . PHE A 1 395 ? 109.897 107.101 121.106 1.00 71.83  ? 395 PHE A CE2 1 
ATOM   2632 C CZ  . PHE A 1 395 ? 110.786 106.692 120.136 1.00 76.35  ? 395 PHE A CZ  1 
ATOM   2633 N N   . GLY A 1 396 ? 112.754 105.579 127.267 1.00 68.75  ? 396 GLY A N   1 
ATOM   2634 C CA  . GLY A 1 396 ? 113.432 105.659 128.551 1.00 72.90  ? 396 GLY A CA  1 
ATOM   2635 C C   . GLY A 1 396 ? 114.487 104.570 128.712 1.00 76.94  ? 396 GLY A C   1 
ATOM   2636 O O   . GLY A 1 396 ? 115.648 104.883 128.937 1.00 96.35  ? 396 GLY A O   1 
ATOM   2637 N N   . THR A 1 397 ? 114.095 103.294 128.582 1.00 77.64  ? 397 THR A N   1 
ATOM   2638 C CA  . THR A 1 397 ? 115.014 102.186 128.771 1.00 80.36  ? 397 THR A CA  1 
ATOM   2639 C C   . THR A 1 397 ? 116.029 102.086 127.629 1.00 82.48  ? 397 THR A C   1 
ATOM   2640 O O   . THR A 1 397 ? 117.153 101.639 127.851 1.00 91.72  ? 397 THR A O   1 
ATOM   2641 C CB  . THR A 1 397 ? 114.275 100.864 129.004 1.00 84.35  ? 397 THR A CB  1 
ATOM   2642 O OG1 . THR A 1 397 ? 113.518 100.515 127.850 1.00 78.99  ? 397 THR A OG1 1 
ATOM   2643 C CG2 . THR A 1 397 ? 113.389 100.912 130.230 1.00 95.39  ? 397 THR A CG2 1 
ATOM   2644 N N   . LEU A 1 398 ? 115.665 102.499 126.412 1.00 81.48  ? 398 LEU A N   1 
ATOM   2645 C CA  . LEU A 1 398 ? 116.641 102.630 125.336 1.00 72.23  ? 398 LEU A CA  1 
ATOM   2646 C C   . LEU A 1 398 ? 117.748 103.607 125.747 1.00 77.44  ? 398 LEU A C   1 
ATOM   2647 O O   . LEU A 1 398 ? 118.915 103.270 125.624 1.00 78.59  ? 398 LEU A O   1 
ATOM   2648 C CB  . LEU A 1 398 ? 115.928 103.055 124.049 1.00 64.89  ? 398 LEU A CB  1 
ATOM   2649 C CG  . LEU A 1 398 ? 116.793 103.290 122.818 1.00 61.78  ? 398 LEU A CG  1 
ATOM   2650 C CD1 . LEU A 1 398 ? 117.559 102.049 122.458 1.00 70.76  ? 398 LEU A CD1 1 
ATOM   2651 C CD2 . LEU A 1 398 ? 115.914 103.703 121.649 1.00 70.18  ? 398 LEU A CD2 1 
ATOM   2652 N N   . THR A 1 399 ? 117.401 104.776 126.313 1.00 78.78  ? 399 THR A N   1 
ATOM   2653 C CA  . THR A 1 399 ? 118.388 105.747 126.779 1.00 67.04  ? 399 THR A CA  1 
ATOM   2654 C C   . THR A 1 399 ? 119.340 105.172 127.840 1.00 69.13  ? 399 THR A C   1 
ATOM   2655 O O   . THR A 1 399 ? 120.532 105.486 127.818 1.00 64.92  ? 399 THR A O   1 
ATOM   2656 C CB  . THR A 1 399 ? 117.717 107.001 127.334 1.00 64.09  ? 399 THR A CB  1 
ATOM   2657 O OG1 . THR A 1 399 ? 116.941 107.584 126.279 1.00 80.37  ? 399 THR A OG1 1 
ATOM   2658 C CG2 . THR A 1 399 ? 118.716 108.013 127.848 1.00 76.36  ? 399 THR A CG2 1 
ATOM   2659 N N   . ILE A 1 400 ? 118.825 104.304 128.729 1.00 73.33  ? 400 ILE A N   1 
ATOM   2660 C CA  . ILE A 1 400 ? 119.643 103.665 129.752 1.00 73.03  ? 400 ILE A CA  1 
ATOM   2661 C C   . ILE A 1 400 ? 120.631 102.694 129.100 1.00 74.86  ? 400 ILE A C   1 
ATOM   2662 O O   . ILE A 1 400 ? 121.820 102.705 129.437 1.00 65.44  ? 400 ILE A O   1 
ATOM   2663 C CB  . ILE A 1 400 ? 118.789 102.962 130.830 1.00 70.84  ? 400 ILE A CB  1 
ATOM   2664 C CG1 . ILE A 1 400 ? 117.806 103.891 131.520 1.00 87.40  ? 400 ILE A CG1 1 
ATOM   2665 C CG2 . ILE A 1 400 ? 119.704 102.345 131.870 1.00 74.98  ? 400 ILE A CG2 1 
ATOM   2666 C CD1 . ILE A 1 400 ? 116.825 103.182 132.411 1.00 106.05 ? 400 ILE A CD1 1 
ATOM   2667 N N   . THR A 1 401 ? 120.139 101.844 128.178 1.00 70.97  ? 401 THR A N   1 
ATOM   2668 C CA  . THR A 1 401 ? 120.961 100.797 127.583 1.00 72.82  ? 401 THR A CA  1 
ATOM   2669 C C   . THR A 1 401 ? 121.943 101.344 126.543 1.00 77.29  ? 401 THR A C   1 
ATOM   2670 O O   . THR A 1 401 ? 122.939 100.688 126.256 1.00 86.06  ? 401 THR A O   1 
ATOM   2671 C CB  . THR A 1 401 ? 120.111 99.660  127.010 1.00 82.02  ? 401 THR A CB  1 
ATOM   2672 O OG1 . THR A 1 401 ? 119.199 100.155 126.035 1.00 79.10  ? 401 THR A OG1 1 
ATOM   2673 C CG2 . THR A 1 401 ? 119.361 98.930  128.106 1.00 110.70 ? 401 THR A CG2 1 
ATOM   2674 N N   . LEU A 1 402 ? 121.686 102.532 125.974 1.00 76.38  ? 402 LEU A N   1 
ATOM   2675 C CA  . LEU A 1 402 ? 122.687 103.231 125.178 1.00 66.66  ? 402 LEU A CA  1 
ATOM   2676 C C   . LEU A 1 402 ? 123.771 103.814 126.088 1.00 63.07  ? 402 LEU A C   1 
ATOM   2677 O O   . LEU A 1 402 ? 124.939 103.815 125.713 1.00 76.52  ? 402 LEU A O   1 
ATOM   2678 C CB  . LEU A 1 402 ? 122.041 104.353 124.354 1.00 61.02  ? 402 LEU A CB  1 
ATOM   2679 C CG  . LEU A 1 402 ? 121.108 103.952 123.221 1.00 71.69  ? 402 LEU A CG  1 
ATOM   2680 C CD1 . LEU A 1 402 ? 120.521 105.182 122.555 1.00 76.14  ? 402 LEU A CD1 1 
ATOM   2681 C CD2 . LEU A 1 402 ? 121.819 103.116 122.190 1.00 72.82  ? 402 LEU A CD2 1 
ATOM   2682 N N   . THR A 1 403 ? 123.397 104.342 127.260 1.00 63.16  ? 403 THR A N   1 
ATOM   2683 C CA  . THR A 1 403 ? 124.337 105.006 128.153 1.00 66.51  ? 403 THR A CA  1 
ATOM   2684 C C   . THR A 1 403 ? 125.274 104.002 128.825 1.00 74.91  ? 403 THR A C   1 
ATOM   2685 O O   . THR A 1 403 ? 126.471 104.253 128.941 1.00 84.39  ? 403 THR A O   1 
ATOM   2686 C CB  . THR A 1 403 ? 123.604 105.834 129.218 1.00 84.14  ? 403 THR A CB  1 
ATOM   2687 O OG1 . THR A 1 403 ? 122.784 106.800 128.562 1.00 84.13  ? 403 THR A OG1 1 
ATOM   2688 C CG2 . THR A 1 403 ? 124.533 106.563 130.161 1.00 99.93  ? 403 THR A CG2 1 
ATOM   2689 N N   . LEU A 1 404 ? 124.729 102.877 129.306 1.00 91.05  ? 404 LEU A N   1 
ATOM   2690 C CA  . LEU A 1 404 ? 125.509 101.887 130.042 1.00 96.33  ? 404 LEU A CA  1 
ATOM   2691 C C   . LEU A 1 404 ? 126.033 100.782 129.112 1.00 96.64  ? 404 LEU A C   1 
ATOM   2692 O O   . LEU A 1 404 ? 126.397 99.708  129.588 1.00 105.86 ? 404 LEU A O   1 
ATOM   2693 C CB  . LEU A 1 404 ? 124.626 101.284 131.146 1.00 105.19 ? 404 LEU A CB  1 
ATOM   2694 C CG  . LEU A 1 404 ? 124.043 102.268 132.163 1.00 106.89 ? 404 LEU A CG  1 
ATOM   2695 C CD1 . LEU A 1 404 ? 123.219 101.538 133.209 1.00 120.18 ? 404 LEU A CD1 1 
ATOM   2696 C CD2 . LEU A 1 404 ? 125.132 103.072 132.845 1.00 109.77 ? 404 LEU A CD2 1 
ATOM   2697 N N   . GLN A 1 405 ? 126.168 101.069 127.808 1.00 82.74  ? 405 GLN A N   1 
ATOM   2698 C CA  . GLN A 1 405 ? 126.497 100.066 126.803 1.00 75.31  ? 405 GLN A CA  1 
ATOM   2699 C C   . GLN A 1 405 ? 127.882 99.463  127.013 1.00 76.91  ? 405 GLN A C   1 
ATOM   2700 O O   . GLN A 1 405 ? 128.167 98.391  126.464 1.00 99.25  ? 405 GLN A O   1 
ATOM   2701 C CB  . GLN A 1 405 ? 126.387 100.653 125.394 1.00 73.92  ? 405 GLN A CB  1 
ATOM   2702 C CG  . GLN A 1 405 ? 127.432 101.703 125.072 1.00 84.45  ? 405 GLN A CG  1 
ATOM   2703 C CD  . GLN A 1 405 ? 127.338 102.178 123.644 1.00 100.65 ? 405 GLN A CD  1 
ATOM   2704 O OE1 . GLN A 1 405 ? 127.975 101.631 122.745 1.00 124.06 ? 405 GLN A OE1 1 
ATOM   2705 N NE2 . GLN A 1 405 ? 126.527 103.198 123.417 1.00 104.06 ? 405 GLN A NE2 1 
ATOM   2706 N N   . ASP A 1 406 ? 128.735 100.130 127.805 1.00 80.52  ? 406 ASP A N   1 
ATOM   2707 C CA  . ASP A 1 406 ? 130.103 99.682  128.030 1.00 99.95  ? 406 ASP A CA  1 
ATOM   2708 C C   . ASP A 1 406 ? 130.231 98.750  129.237 1.00 100.99 ? 406 ASP A C   1 
ATOM   2709 O O   . ASP A 1 406 ? 131.314 98.215  129.466 1.00 111.91 ? 406 ASP A O   1 
ATOM   2710 C CB  . ASP A 1 406 ? 131.039 100.874 128.231 1.00 131.85 ? 406 ASP A CB  1 
ATOM   2711 C CG  . ASP A 1 406 ? 131.043 101.846 127.060 1.00 177.70 ? 406 ASP A CG  1 
ATOM   2712 O OD1 . ASP A 1 406 ? 131.481 101.440 125.960 1.00 191.82 ? 406 ASP A OD1 1 
ATOM   2713 O OD2 . ASP A 1 406 ? 130.586 102.997 127.249 1.00 203.44 ? 406 ASP A OD2 1 
ATOM   2714 N N   . HIS A 1 407 ? 129.158 98.562  130.024 1.00 102.30 ? 407 HIS A N   1 
ATOM   2715 C CA  . HIS A 1 407 ? 129.249 97.878  131.312 1.00 122.01 ? 407 HIS A CA  1 
ATOM   2716 C C   . HIS A 1 407 ? 129.298 96.358  131.172 1.00 122.78 ? 407 HIS A C   1 
ATOM   2717 O O   . HIS A 1 407 ? 129.893 95.687  132.018 1.00 139.63 ? 407 HIS A O   1 
ATOM   2718 C CB  . HIS A 1 407 ? 128.131 98.327  132.265 1.00 129.44 ? 407 HIS A CB  1 
ATOM   2719 C CG  . HIS A 1 407 ? 128.383 99.679  132.844 1.00 155.49 ? 407 HIS A CG  1 
ATOM   2720 N ND1 . HIS A 1 407 ? 128.662 99.897  134.178 1.00 181.18 ? 407 HIS A ND1 1 
ATOM   2721 C CD2 . HIS A 1 407 ? 128.455 100.876 132.244 1.00 166.55 ? 407 HIS A CD2 1 
ATOM   2722 C CE1 . HIS A 1 407 ? 128.869 101.193 134.371 1.00 197.97 ? 407 HIS A CE1 1 
ATOM   2723 N NE2 . HIS A 1 407 ? 128.748 101.805 133.210 1.00 188.98 ? 407 HIS A NE2 1 
ATOM   2724 N N   . ALA A 1 408 ? 128.659 95.825  130.126 1.00 118.54 ? 408 ALA A N   1 
ATOM   2725 C CA  . ALA A 1 408 ? 128.694 94.397  129.849 1.00 136.28 ? 408 ALA A CA  1 
ATOM   2726 C C   . ALA A 1 408 ? 128.382 94.154  128.372 1.00 131.26 ? 408 ALA A C   1 
ATOM   2727 O O   . ALA A 1 408 ? 127.597 94.888  127.776 1.00 130.32 ? 408 ALA A O   1 
ATOM   2728 C CB  . ALA A 1 408 ? 127.726 93.691  130.768 1.00 155.61 ? 408 ALA A CB  1 
ATOM   2729 N N   . PRO A 1 409 ? 128.959 93.105  127.736 1.00 118.36 ? 409 PRO A N   1 
ATOM   2730 C CA  . PRO A 1 409 ? 128.865 92.942  126.283 1.00 118.73 ? 409 PRO A CA  1 
ATOM   2731 C C   . PRO A 1 409 ? 127.483 92.582  125.729 1.00 115.82 ? 409 PRO A C   1 
ATOM   2732 O O   . PRO A 1 409 ? 127.255 92.704  124.524 1.00 117.15 ? 409 PRO A O   1 
ATOM   2733 C CB  . PRO A 1 409 ? 129.880 91.824  125.992 1.00 131.94 ? 409 PRO A CB  1 
ATOM   2734 C CG  . PRO A 1 409 ? 129.937 91.022  127.279 1.00 136.64 ? 409 PRO A CG  1 
ATOM   2735 C CD  . PRO A 1 409 ? 129.748 92.042  128.379 1.00 125.10 ? 409 PRO A CD  1 
ATOM   2736 N N   . TRP A 1 410 ? 126.552 92.175  126.606 1.00 100.87 ? 410 TRP A N   1 
ATOM   2737 C CA  . TRP A 1 410 ? 125.192 91.859  126.201 1.00 89.06  ? 410 TRP A CA  1 
ATOM   2738 C C   . TRP A 1 410 ? 124.297 93.097  126.179 1.00 80.42  ? 410 TRP A C   1 
ATOM   2739 O O   . TRP A 1 410 ? 123.189 93.028  125.649 1.00 102.98 ? 410 TRP A O   1 
ATOM   2740 C CB  . TRP A 1 410 ? 124.590 90.770  127.103 1.00 91.90  ? 410 TRP A CB  1 
ATOM   2741 C CG  . TRP A 1 410 ? 124.849 90.951  128.572 1.00 85.13  ? 410 TRP A CG  1 
ATOM   2742 C CD1 . TRP A 1 410 ? 125.838 90.344  129.284 1.00 106.70 ? 410 TRP A CD1 1 
ATOM   2743 C CD2 . TRP A 1 410 ? 124.106 91.755  129.517 1.00 97.44  ? 410 TRP A CD2 1 
ATOM   2744 N NE1 . TRP A 1 410 ? 125.788 90.729  130.596 1.00 117.10 ? 410 TRP A NE1 1 
ATOM   2745 C CE2 . TRP A 1 410 ? 124.737 91.591  130.772 1.00 106.57 ? 410 TRP A CE2 1 
ATOM   2746 C CE3 . TRP A 1 410 ? 122.986 92.597  129.432 1.00 93.54  ? 410 TRP A CE3 1 
ATOM   2747 C CZ2 . TRP A 1 410 ? 124.290 92.236  131.923 1.00 99.42  ? 410 TRP A CZ2 1 
ATOM   2748 C CZ3 . TRP A 1 410 ? 122.548 93.239  130.566 1.00 101.01 ? 410 TRP A CZ3 1 
ATOM   2749 C CH2 . TRP A 1 410 ? 123.191 93.057  131.794 1.00 112.07 ? 410 TRP A CH2 1 
ATOM   2750 N N   . VAL A 1 411 ? 124.758 94.243  126.704 1.00 72.45  ? 411 VAL A N   1 
ATOM   2751 C CA  . VAL A 1 411 ? 123.876 95.393  126.882 1.00 65.61  ? 411 VAL A CA  1 
ATOM   2752 C C   . VAL A 1 411 ? 123.440 95.970  125.531 1.00 64.67  ? 411 VAL A C   1 
ATOM   2753 O O   . VAL A 1 411 ? 122.265 96.296  125.377 1.00 81.72  ? 411 VAL A O   1 
ATOM   2754 C CB  . VAL A 1 411 ? 124.470 96.473  127.803 1.00 66.34  ? 411 VAL A CB  1 
ATOM   2755 C CG1 . VAL A 1 411 ? 123.572 97.695  127.869 1.00 70.92  ? 411 VAL A CG1 1 
ATOM   2756 C CG2 . VAL A 1 411 ? 124.721 95.948  129.205 1.00 71.00  ? 411 VAL A CG2 1 
ATOM   2757 N N   . PRO A 1 412 ? 124.314 96.151  124.512 1.00 69.67  ? 412 PRO A N   1 
ATOM   2758 C CA  . PRO A 1 412 ? 123.871 96.668  123.216 1.00 74.68  ? 412 PRO A CA  1 
ATOM   2759 C C   . PRO A 1 412 ? 122.695 95.932  122.583 1.00 78.21  ? 412 PRO A C   1 
ATOM   2760 O O   . PRO A 1 412 ? 121.879 96.558  121.906 1.00 83.83  ? 412 PRO A O   1 
ATOM   2761 C CB  . PRO A 1 412 ? 125.127 96.520  122.343 1.00 79.97  ? 412 PRO A CB  1 
ATOM   2762 C CG  . PRO A 1 412 ? 126.265 96.690  123.327 1.00 80.04  ? 412 PRO A CG  1 
ATOM   2763 C CD  . PRO A 1 412 ? 125.774 95.980  124.566 1.00 75.21  ? 412 PRO A CD  1 
ATOM   2764 N N   . TYR A 1 413 ? 122.591 94.613  122.820 1.00 87.14  ? 413 TYR A N   1 
ATOM   2765 C CA  . TYR A 1 413 ? 121.514 93.804  122.264 1.00 90.85  ? 413 TYR A CA  1 
ATOM   2766 C C   . TYR A 1 413 ? 120.176 94.121  122.943 1.00 87.20  ? 413 TYR A C   1 
ATOM   2767 O O   . TYR A 1 413 ? 119.134 93.931  122.324 1.00 91.48  ? 413 TYR A O   1 
ATOM   2768 C CB  . TYR A 1 413 ? 121.913 92.329  122.331 1.00 98.49  ? 413 TYR A CB  1 
ATOM   2769 C CG  . TYR A 1 413 ? 123.157 92.022  121.512 1.00 112.95 ? 413 TYR A CG  1 
ATOM   2770 C CD1 . TYR A 1 413 ? 123.097 91.830  120.136 1.00 126.61 ? 413 TYR A CD1 1 
ATOM   2771 C CD2 . TYR A 1 413 ? 124.406 91.987  122.113 1.00 145.65 ? 413 TYR A CD2 1 
ATOM   2772 C CE1 . TYR A 1 413 ? 124.236 91.567  119.390 1.00 141.09 ? 413 TYR A CE1 1 
ATOM   2773 C CE2 . TYR A 1 413 ? 125.554 91.722  121.380 1.00 161.23 ? 413 TYR A CE2 1 
ATOM   2774 C CZ  . TYR A 1 413 ? 125.469 91.515  120.014 1.00 154.78 ? 413 TYR A CZ  1 
ATOM   2775 O OH  . TYR A 1 413 ? 126.604 91.262  119.295 1.00 170.08 ? 413 TYR A OH  1 
ATOM   2776 N N   . LEU A 1 414 ? 120.188 94.639  124.177 1.00 83.12  ? 414 LEU A N   1 
ATOM   2777 C CA  . LEU A 1 414 ? 118.961 95.109  124.820 1.00 76.60  ? 414 LEU A CA  1 
ATOM   2778 C C   . LEU A 1 414 ? 118.411 96.354  124.122 1.00 79.23  ? 414 LEU A C   1 
ATOM   2779 O O   . LEU A 1 414 ? 117.214 96.617  124.232 1.00 102.22 ? 414 LEU A O   1 
ATOM   2780 C CB  . LEU A 1 414 ? 119.200 95.411  126.312 1.00 60.69  ? 414 LEU A CB  1 
ATOM   2781 C CG  . LEU A 1 414 ? 119.561 94.211  127.173 1.00 63.33  ? 414 LEU A CG  1 
ATOM   2782 C CD1 . LEU A 1 414 ? 119.623 94.598  128.624 1.00 74.30  ? 414 LEU A CD1 1 
ATOM   2783 C CD2 . LEU A 1 414 ? 118.567 93.096  126.976 1.00 79.18  ? 414 LEU A CD2 1 
ATOM   2784 N N   . SER A 1 415 ? 119.257 97.129  123.429 1.00 78.43  ? 415 SER A N   1 
ATOM   2785 C CA  . SER A 1 415 ? 118.779 98.267  122.659 1.00 77.35  ? 415 SER A CA  1 
ATOM   2786 C C   . SER A 1 415 ? 118.062 97.813  121.385 1.00 75.09  ? 415 SER A C   1 
ATOM   2787 O O   . SER A 1 415 ? 117.256 98.575  120.849 1.00 83.81  ? 415 SER A O   1 
ATOM   2788 C CB  . SER A 1 415 ? 119.889 99.239  122.356 1.00 82.01  ? 415 SER A CB  1 
ATOM   2789 O OG  . SER A 1 415 ? 120.525 99.669  123.558 1.00 90.14  ? 415 SER A OG  1 
ATOM   2790 N N   . ILE A 1 416 ? 118.327 96.590  120.892 1.00 69.76  ? 416 ILE A N   1 
ATOM   2791 C CA  . ILE A 1 416 ? 117.546 96.033  119.790 1.00 75.04  ? 416 ILE A CA  1 
ATOM   2792 C C   . ILE A 1 416 ? 116.130 95.729  120.280 1.00 84.32  ? 416 ILE A C   1 
ATOM   2793 O O   . ILE A 1 416 ? 115.166 96.138  119.643 1.00 94.96  ? 416 ILE A O   1 
ATOM   2794 C CB  . ILE A 1 416 ? 118.200 94.784  119.165 1.00 76.06  ? 416 ILE A CB  1 
ATOM   2795 C CG1 . ILE A 1 416 ? 119.619 95.042  118.671 1.00 78.96  ? 416 ILE A CG1 1 
ATOM   2796 C CG2 . ILE A 1 416 ? 117.339 94.253  118.035 1.00 83.61  ? 416 ILE A CG2 1 
ATOM   2797 C CD1 . ILE A 1 416 ? 120.366 93.775  118.319 1.00 86.89  ? 416 ILE A CD1 1 
ATOM   2798 N N   . VAL A 1 417 ? 116.009 95.041  121.425 1.00 84.96  ? 417 VAL A N   1 
ATOM   2799 C CA  . VAL A 1 417 ? 114.719 94.730  122.040 1.00 65.25  ? 417 VAL A CA  1 
ATOM   2800 C C   . VAL A 1 417 ? 113.969 96.028  122.382 1.00 64.93  ? 417 VAL A C   1 
ATOM   2801 O O   . VAL A 1 417 ? 112.766 96.114  122.202 1.00 70.04  ? 417 VAL A O   1 
ATOM   2802 C CB  . VAL A 1 417 ? 114.909 93.845  123.287 1.00 65.21  ? 417 VAL A CB  1 
ATOM   2803 C CG1 . VAL A 1 417 ? 113.597 93.518  123.964 1.00 81.91  ? 417 VAL A CG1 1 
ATOM   2804 C CG2 . VAL A 1 417 ? 115.639 92.562  122.972 1.00 71.18  ? 417 VAL A CG2 1 
ATOM   2805 N N   . GLY A 1 418 ? 114.692 97.056  122.836 1.00 69.64  ? 418 GLY A N   1 
ATOM   2806 C CA  . GLY A 1 418 ? 114.145 98.384  123.065 1.00 66.79  ? 418 GLY A CA  1 
ATOM   2807 C C   . GLY A 1 418 ? 113.558 99.029  121.815 1.00 56.12  ? 418 GLY A C   1 
ATOM   2808 O O   . GLY A 1 418 ? 112.460 99.547  121.861 1.00 72.24  ? 418 GLY A O   1 
ATOM   2809 N N   . ILE A 1 419 ? 114.286 99.035  120.701 1.00 62.90  ? 419 ILE A N   1 
ATOM   2810 C CA  . ILE A 1 419 ? 113.796 99.626  119.462 1.00 65.39  ? 419 ILE A CA  1 
ATOM   2811 C C   . ILE A 1 419 ? 112.628 98.811  118.919 1.00 72.18  ? 419 ILE A C   1 
ATOM   2812 O O   . ILE A 1 419 ? 111.672 99.403  118.424 1.00 80.17  ? 419 ILE A O   1 
ATOM   2813 C CB  . ILE A 1 419 ? 114.959 99.838  118.454 1.00 66.86  ? 419 ILE A CB  1 
ATOM   2814 C CG1 . ILE A 1 419 ? 115.784 101.052 118.888 1.00 82.51  ? 419 ILE A CG1 1 
ATOM   2815 C CG2 . ILE A 1 419 ? 114.475 100.007 117.025 1.00 61.95  ? 419 ILE A CG2 1 
ATOM   2816 C CD1 . ILE A 1 419 ? 117.158 101.142 118.293 1.00 102.63 ? 419 ILE A CD1 1 
ATOM   2817 N N   . LEU A 1 420 ? 112.663 97.470  119.015 1.00 77.67  ? 420 LEU A N   1 
ATOM   2818 C CA  . LEU A 1 420 ? 111.567 96.635  118.525 1.00 70.25  ? 420 LEU A CA  1 
ATOM   2819 C C   . LEU A 1 420 ? 110.294 96.817  119.363 1.00 71.10  ? 420 LEU A C   1 
ATOM   2820 O O   . LEU A 1 420 ? 109.204 96.810  118.802 1.00 74.39  ? 420 LEU A O   1 
ATOM   2821 C CB  . LEU A 1 420 ? 112.004 95.167  118.488 1.00 66.18  ? 420 LEU A CB  1 
ATOM   2822 C CG  . LEU A 1 420 ? 113.052 94.809  117.426 1.00 73.91  ? 420 LEU A CG  1 
ATOM   2823 C CD1 . LEU A 1 420 ? 113.194 93.298  117.300 1.00 71.90  ? 420 LEU A CD1 1 
ATOM   2824 C CD2 . LEU A 1 420 ? 112.726 95.417  116.060 1.00 81.13  ? 420 LEU A CD2 1 
ATOM   2825 N N   . ALA A 1 421 ? 110.414 97.013  120.683 1.00 64.30  ? 421 ALA A N   1 
ATOM   2826 C CA  . ALA A 1 421 ? 109.263 97.261  121.538 1.00 61.17  ? 421 ALA A CA  1 
ATOM   2827 C C   . ALA A 1 421 ? 108.615 98.624  121.254 1.00 55.59  ? 421 ALA A C   1 
ATOM   2828 O O   . ALA A 1 421 ? 107.414 98.779  121.428 1.00 64.69  ? 421 ALA A O   1 
ATOM   2829 C CB  . ALA A 1 421 ? 109.662 97.112  122.991 1.00 63.69  ? 421 ALA A CB  1 
ATOM   2830 N N   . ILE A 1 422 ? 109.382 99.604  120.783 1.00 56.96  ? 422 ILE A N   1 
ATOM   2831 C CA  . ILE A 1 422 ? 108.850 100.885 120.334 1.00 56.21  ? 422 ILE A CA  1 
ATOM   2832 C C   . ILE A 1 422 ? 108.034 100.695 119.057 1.00 51.07  ? 422 ILE A C   1 
ATOM   2833 O O   . ILE A 1 422 ? 106.935 101.214 118.958 1.00 60.47  ? 422 ILE A O   1 
ATOM   2834 C CB  . ILE A 1 422 ? 109.987 101.922 120.162 1.00 64.74  ? 422 ILE A CB  1 
ATOM   2835 C CG1 . ILE A 1 422 ? 110.572 102.329 121.516 1.00 73.68  ? 422 ILE A CG1 1 
ATOM   2836 C CG2 . ILE A 1 422 ? 109.548 103.146 119.376 1.00 61.71  ? 422 ILE A CG2 1 
ATOM   2837 C CD1 . ILE A 1 422 ? 111.984 102.865 121.427 1.00 77.95  ? 422 ILE A CD1 1 
ATOM   2838 N N   . ILE A 1 423 ? 108.545 99.918  118.097 1.00 62.61  ? 423 ILE A N   1 
ATOM   2839 C CA  . ILE A 1 423 ? 107.887 99.701  116.811 1.00 65.12  ? 423 ILE A CA  1 
ATOM   2840 C C   . ILE A 1 423 ? 106.604 98.889  117.002 1.00 62.26  ? 423 ILE A C   1 
ATOM   2841 O O   . ILE A 1 423 ? 105.600 99.170  116.353 1.00 63.20  ? 423 ILE A O   1 
ATOM   2842 C CB  . ILE A 1 423 ? 108.872 99.036  115.819 1.00 66.14  ? 423 ILE A CB  1 
ATOM   2843 C CG1 . ILE A 1 423 ? 110.028 99.979  115.486 1.00 66.24  ? 423 ILE A CG1 1 
ATOM   2844 C CG2 . ILE A 1 423 ? 108.177 98.570  114.543 1.00 68.16  ? 423 ILE A CG2 1 
ATOM   2845 C CD1 . ILE A 1 423 ? 111.265 99.267  115.021 1.00 66.11  ? 423 ILE A CD1 1 
ATOM   2846 N N   . ALA A 1 424 ? 106.635 97.883  117.885 1.00 59.89  ? 424 ALA A N   1 
ATOM   2847 C CA  . ALA A 1 424 ? 105.472 97.063  118.180 1.00 62.41  ? 424 ALA A CA  1 
ATOM   2848 C C   . ALA A 1 424 ? 104.407 97.856  118.940 1.00 69.44  ? 424 ALA A C   1 
ATOM   2849 O O   . ALA A 1 424 ? 103.221 97.637  118.711 1.00 81.36  ? 424 ALA A O   1 
ATOM   2850 C CB  . ALA A 1 424 ? 105.903 95.836  118.953 1.00 68.72  ? 424 ALA A CB  1 
ATOM   2851 N N   . SER A 1 425 ? 104.812 98.776  119.830 1.00 71.73  ? 425 SER A N   1 
ATOM   2852 C CA  . SER A 1 425 ? 103.888 99.602  120.604 1.00 73.02  ? 425 SER A CA  1 
ATOM   2853 C C   . SER A 1 425 ? 103.147 100.610 119.730 1.00 62.62  ? 425 SER A C   1 
ATOM   2854 O O   . SER A 1 425 ? 101.987 100.893 119.982 1.00 85.49  ? 425 SER A O   1 
ATOM   2855 C CB  . SER A 1 425 ? 104.593 100.324 121.725 1.00 82.46  ? 425 SER A CB  1 
ATOM   2856 O OG  . SER A 1 425 ? 105.141 99.397  122.653 1.00 98.35  ? 425 SER A OG  1 
ATOM   2857 N N   . PHE A 1 426 ? 103.827 101.179 118.739 1.00 69.58  ? 426 PHE A N   1 
ATOM   2858 C CA  . PHE A 1 426 ? 103.223 102.106 117.795 1.00 69.71  ? 426 PHE A CA  1 
ATOM   2859 C C   . PHE A 1 426 ? 102.212 101.394 116.883 1.00 73.40  ? 426 PHE A C   1 
ATOM   2860 O O   . PHE A 1 426 ? 101.071 101.819 116.799 1.00 78.90  ? 426 PHE A O   1 
ATOM   2861 C CB  . PHE A 1 426 ? 104.325 102.771 116.975 1.00 67.98  ? 426 PHE A CB  1 
ATOM   2862 C CG  . PHE A 1 426 ? 103.883 103.816 115.986 1.00 79.37  ? 426 PHE A CG  1 
ATOM   2863 C CD1 . PHE A 1 426 ? 103.741 105.136 116.371 1.00 89.84  ? 426 PHE A CD1 1 
ATOM   2864 C CD2 . PHE A 1 426 ? 103.606 103.480 114.670 1.00 91.95  ? 426 PHE A CD2 1 
ATOM   2865 C CE1 . PHE A 1 426 ? 103.328 106.099 115.471 1.00 83.34  ? 426 PHE A CE1 1 
ATOM   2866 C CE2 . PHE A 1 426 ? 103.204 104.443 113.765 1.00 92.97  ? 426 PHE A CE2 1 
ATOM   2867 C CZ  . PHE A 1 426 ? 103.077 105.749 114.170 1.00 83.67  ? 426 PHE A CZ  1 
ATOM   2868 N N   . CYS A 1 427 ? 102.600 100.300 116.221 1.00 78.83  ? 427 CYS A N   1 
ATOM   2869 C CA  . CYS A 1 427 ? 101.768 99.671  115.202 1.00 94.01  ? 427 CYS A CA  1 
ATOM   2870 C C   . CYS A 1 427 ? 100.557 98.921  115.776 1.00 100.67 ? 427 CYS A C   1 
ATOM   2871 O O   . CYS A 1 427 ? 99.553  98.749  115.081 1.00 109.39 ? 427 CYS A O   1 
ATOM   2872 C CB  . CYS A 1 427 ? 102.616 98.746  114.344 1.00 98.46  ? 427 CYS A CB  1 
ATOM   2873 S SG  . CYS A 1 427 ? 103.989 99.648  113.579 1.00 119.96 ? 427 CYS A SG  1 
ATOM   2874 N N   . SER A 1 428 ? 100.633 98.498  117.046 1.00 102.19 ? 428 SER A N   1 
ATOM   2875 C CA  . SER A 1 428 ? 99.514  97.832  117.701 1.00 110.12 ? 428 SER A CA  1 
ATOM   2876 C C   . SER A 1 428 ? 98.394  98.808  118.081 1.00 116.25 ? 428 SER A C   1 
ATOM   2877 O O   . SER A 1 428 ? 97.298  98.365  118.428 1.00 132.44 ? 428 SER A O   1 
ATOM   2878 C CB  . SER A 1 428 ? 99.980  97.081  118.927 1.00 117.75 ? 428 SER A CB  1 
ATOM   2879 O OG  . SER A 1 428 ? 100.970 96.113  118.595 1.00 123.85 ? 428 SER A OG  1 
ATOM   2880 N N   . GLY A 1 429 ? 98.657  100.124 118.036 1.00 100.89 ? 429 GLY A N   1 
ATOM   2881 C CA  . GLY A 1 429 ? 97.741  101.131 118.556 1.00 94.64  ? 429 GLY A CA  1 
ATOM   2882 C C   . GLY A 1 429 ? 97.777  102.446 117.773 1.00 91.16  ? 429 GLY A C   1 
ATOM   2883 O O   . GLY A 1 429 ? 97.038  102.625 116.797 1.00 97.37  ? 429 GLY A O   1 
ATOM   2884 N N   . PRO A 1 430 ? 98.610  103.417 118.203 1.00 85.31  ? 430 PRO A N   1 
ATOM   2885 C CA  . PRO A 1 430 ? 98.732  104.721 117.540 1.00 93.76  ? 430 PRO A CA  1 
ATOM   2886 C C   . PRO A 1 430 ? 98.880  104.729 116.016 1.00 85.30  ? 430 PRO A C   1 
ATOM   2887 O O   . PRO A 1 430 ? 98.513  105.709 115.394 1.00 97.84  ? 430 PRO A O   1 
ATOM   2888 C CB  . PRO A 1 430 ? 100.003 105.327 118.166 1.00 91.22  ? 430 PRO A CB  1 
ATOM   2889 C CG  . PRO A 1 430 ? 100.024 104.735 119.553 1.00 103.20 ? 430 PRO A CG  1 
ATOM   2890 C CD  . PRO A 1 430 ? 99.457  103.329 119.392 1.00 87.11  ? 430 PRO A CD  1 
ATOM   2891 N N   . GLY A 1 431 ? 99.386  103.655 115.414 1.00 83.04  ? 431 GLY A N   1 
ATOM   2892 C CA  . GLY A 1 431 ? 99.615  103.595 113.981 1.00 98.17  ? 431 GLY A CA  1 
ATOM   2893 C C   . GLY A 1 431 ? 98.385  103.932 113.133 1.00 120.22 ? 431 GLY A C   1 
ATOM   2894 O O   . GLY A 1 431 ? 98.534  104.504 112.045 1.00 136.39 ? 431 GLY A O   1 
ATOM   2895 N N   . GLY A 1 432 ? 97.184  103.543 113.611 1.00 120.65 ? 432 GLY A N   1 
ATOM   2896 C CA  . GLY A 1 432 ? 95.944  103.637 112.845 1.00 113.24 ? 432 GLY A CA  1 
ATOM   2897 C C   . GLY A 1 432 ? 94.941  104.675 113.366 1.00 98.58  ? 432 GLY A C   1 
ATOM   2898 O O   . GLY A 1 432 ? 94.228  105.281 112.574 1.00 106.58 ? 432 GLY A O   1 
ATOM   2899 N N   . ILE A 1 433 ? 94.904  104.900 114.688 1.00 90.62  ? 433 ILE A N   1 
ATOM   2900 C CA  . ILE A 1 433 ? 93.763  105.534 115.338 1.00 85.82  ? 433 ILE A CA  1 
ATOM   2901 C C   . ILE A 1 433 ? 93.643  107.032 115.017 1.00 97.69  ? 433 ILE A C   1 
ATOM   2902 O O   . ILE A 1 433 ? 92.519  107.512 114.905 1.00 104.66 ? 433 ILE A O   1 
ATOM   2903 C CB  . ILE A 1 433 ? 93.768  105.232 116.853 1.00 88.48  ? 433 ILE A CB  1 
ATOM   2904 C CG1 . ILE A 1 433 ? 93.336  103.786 117.094 1.00 100.49 ? 433 ILE A CG1 1 
ATOM   2905 C CG2 . ILE A 1 433 ? 92.896  106.204 117.646 1.00 90.15  ? 433 ILE A CG2 1 
ATOM   2906 C CD1 . ILE A 1 433 ? 93.570  103.282 118.488 1.00 104.06 ? 433 ILE A CD1 1 
ATOM   2907 N N   . PRO A 1 434 ? 94.716  107.848 114.868 1.00 107.96 ? 434 PRO A N   1 
ATOM   2908 C CA  . PRO A 1 434 ? 94.556  109.272 114.553 1.00 115.83 ? 434 PRO A CA  1 
ATOM   2909 C C   . PRO A 1 434 ? 93.661  109.628 113.363 1.00 114.98 ? 434 PRO A C   1 
ATOM   2910 O O   . PRO A 1 434 ? 92.929  110.618 113.426 1.00 136.27 ? 434 PRO A O   1 
ATOM   2911 C CB  . PRO A 1 434 ? 96.007  109.730 114.317 1.00 112.59 ? 434 PRO A CB  1 
ATOM   2912 C CG  . PRO A 1 434 ? 96.801  108.852 115.245 1.00 98.55  ? 434 PRO A CG  1 
ATOM   2913 C CD  . PRO A 1 434 ? 96.123  107.504 115.112 1.00 109.36 ? 434 PRO A CD  1 
ATOM   2914 N N   . PHE A 1 435 ? 93.686  108.823 112.294 1.00 107.68 ? 435 PHE A N   1 
ATOM   2915 C CA  . PHE A 1 435 ? 92.856  109.074 111.121 1.00 121.02 ? 435 PHE A CA  1 
ATOM   2916 C C   . PHE A 1 435 ? 91.413  108.603 111.339 1.00 114.67 ? 435 PHE A C   1 
ATOM   2917 O O   . PHE A 1 435 ? 90.491  109.125 110.715 1.00 119.97 ? 435 PHE A O   1 
ATOM   2918 C CB  . PHE A 1 435 ? 93.516  108.442 109.896 1.00 146.68 ? 435 PHE A CB  1 
ATOM   2919 C CG  . PHE A 1 435 ? 94.839  109.075 109.551 1.00 175.38 ? 435 PHE A CG  1 
ATOM   2920 C CD1 . PHE A 1 435 ? 94.879  110.301 108.899 1.00 181.73 ? 435 PHE A CD1 1 
ATOM   2921 C CD2 . PHE A 1 435 ? 96.038  108.485 109.936 1.00 185.89 ? 435 PHE A CD2 1 
ATOM   2922 C CE1 . PHE A 1 435 ? 96.093  110.901 108.594 1.00 199.83 ? 435 PHE A CE1 1 
ATOM   2923 C CE2 . PHE A 1 435 ? 97.251  109.088 109.636 1.00 194.44 ? 435 PHE A CE2 1 
ATOM   2924 C CZ  . PHE A 1 435 ? 97.277  110.292 108.961 1.00 208.95 ? 435 PHE A CZ  1 
ATOM   2925 N N   . ILE A 1 436 ? 91.219  107.617 112.226 1.00 102.95 ? 436 ILE A N   1 
ATOM   2926 C CA  . ILE A 1 436 ? 89.899  107.187 112.671 1.00 92.23  ? 436 ILE A CA  1 
ATOM   2927 C C   . ILE A 1 436 ? 89.252  108.306 113.499 1.00 90.09  ? 436 ILE A C   1 
ATOM   2928 O O   . ILE A 1 436 ? 88.120  108.695 113.205 1.00 105.41 ? 436 ILE A O   1 
ATOM   2929 C CB  . ILE A 1 436 ? 89.996  105.821 113.398 1.00 102.56 ? 436 ILE A CB  1 
ATOM   2930 C CG1 . ILE A 1 436 ? 89.835  104.649 112.426 1.00 117.62 ? 436 ILE A CG1 1 
ATOM   2931 C CG2 . ILE A 1 436 ? 89.010  105.685 114.552 1.00 108.43 ? 436 ILE A CG2 1 
ATOM   2932 C CD1 . ILE A 1 436 ? 90.788  104.658 111.256 1.00 127.76 ? 436 ILE A CD1 1 
ATOM   2933 N N   . LEU A 1 437 ? 89.977  108.876 114.478 1.00 82.08  ? 437 LEU A N   1 
ATOM   2934 C CA  . LEU A 1 437 ? 89.439  109.930 115.328 1.00 86.87  ? 437 LEU A CA  1 
ATOM   2935 C C   . LEU A 1 437 ? 89.038  111.162 114.517 1.00 88.45  ? 437 LEU A C   1 
ATOM   2936 O O   . LEU A 1 437 ? 88.018  111.780 114.828 1.00 90.57  ? 437 LEU A O   1 
ATOM   2937 C CB  . LEU A 1 437 ? 90.461  110.321 116.402 1.00 83.54  ? 437 LEU A CB  1 
ATOM   2938 C CG  . LEU A 1 437 ? 90.631  109.339 117.553 1.00 93.88  ? 437 LEU A CG  1 
ATOM   2939 C CD1 . LEU A 1 437 ? 91.680  109.860 118.519 1.00 98.53  ? 437 LEU A CD1 1 
ATOM   2940 C CD2 . LEU A 1 437 ? 89.316  109.076 118.279 1.00 96.93  ? 437 LEU A CD2 1 
ATOM   2941 N N   . THR A 1 438 ? 89.845  111.541 113.515 1.00 91.24  ? 438 THR A N   1 
ATOM   2942 C CA  . THR A 1 438 ? 89.575  112.733 112.720 1.00 87.92  ? 438 THR A CA  1 
ATOM   2943 C C   . THR A 1 438 ? 88.234  112.605 111.991 1.00 84.67  ? 438 THR A C   1 
ATOM   2944 O O   . THR A 1 438 ? 87.602  113.609 111.672 1.00 85.08  ? 438 THR A O   1 
ATOM   2945 C CB  . THR A 1 438 ? 90.735  113.024 111.757 1.00 89.05  ? 438 THR A CB  1 
ATOM   2946 O OG1 . THR A 1 438 ? 91.964  113.059 112.480 1.00 107.32 ? 438 THR A OG1 1 
ATOM   2947 C CG2 . THR A 1 438 ? 90.584  114.337 111.022 1.00 85.46  ? 438 THR A CG2 1 
ATOM   2948 N N   . GLY A 1 439 ? 87.806  111.369 111.699 1.00 92.97  ? 439 GLY A N   1 
ATOM   2949 C CA  . GLY A 1 439 ? 86.483  111.119 111.142 1.00 96.97  ? 439 GLY A CA  1 
ATOM   2950 C C   . GLY A 1 439 ? 85.382  111.178 112.202 1.00 105.34 ? 439 GLY A C   1 
ATOM   2951 O O   . GLY A 1 439 ? 84.337  111.765 111.956 1.00 128.91 ? 439 GLY A O   1 
ATOM   2952 N N   . GLU A 1 440 ? 85.622  110.588 113.383 1.00 93.76  ? 440 GLU A N   1 
ATOM   2953 C CA  . GLU A 1 440 ? 84.612  110.462 114.422 1.00 87.04  ? 440 GLU A CA  1 
ATOM   2954 C C   . GLU A 1 440 ? 84.273  111.800 115.086 1.00 87.74  ? 440 GLU A C   1 
ATOM   2955 O O   . GLU A 1 440 ? 83.188  111.935 115.651 1.00 88.10  ? 440 GLU A O   1 
ATOM   2956 C CB  . GLU A 1 440 ? 85.077  109.438 115.460 1.00 106.77 ? 440 GLU A CB  1 
ATOM   2957 C CG  . GLU A 1 440 ? 85.039  108.011 114.936 1.00 133.65 ? 440 GLU A CG  1 
ATOM   2958 C CD  . GLU A 1 440 ? 85.583  106.936 115.862 1.00 152.94 ? 440 GLU A CD  1 
ATOM   2959 O OE1 . GLU A 1 440 ? 86.141  107.287 116.920 1.00 143.78 ? 440 GLU A OE1 1 
ATOM   2960 O OE2 . GLU A 1 440 ? 85.455  105.740 115.525 1.00 180.90 ? 440 GLU A OE2 1 
ATOM   2961 N N   . PHE A 1 441 ? 85.183  112.792 115.028 1.00 79.45  ? 441 PHE A N   1 
ATOM   2962 C CA  . PHE A 1 441 ? 85.001  114.069 115.711 1.00 73.74  ? 441 PHE A CA  1 
ATOM   2963 C C   . PHE A 1 441 ? 84.120  115.076 114.951 1.00 80.56  ? 441 PHE A C   1 
ATOM   2964 O O   . PHE A 1 441 ? 83.540  115.967 115.578 1.00 77.21  ? 441 PHE A O   1 
ATOM   2965 C CB  . PHE A 1 441 ? 86.345  114.754 115.925 1.00 84.89  ? 441 PHE A CB  1 
ATOM   2966 C CG  . PHE A 1 441 ? 87.243  114.213 117.015 1.00 93.72  ? 441 PHE A CG  1 
ATOM   2967 C CD1 . PHE A 1 441 ? 86.825  113.265 117.930 1.00 87.05  ? 441 PHE A CD1 1 
ATOM   2968 C CD2 . PHE A 1 441 ? 88.543  114.684 117.113 1.00 99.99  ? 441 PHE A CD2 1 
ATOM   2969 C CE1 . PHE A 1 441 ? 87.687  112.794 118.906 1.00 79.37  ? 441 PHE A CE1 1 
ATOM   2970 C CE2 . PHE A 1 441 ? 89.407  114.191 118.071 1.00 100.32 ? 441 PHE A CE2 1 
ATOM   2971 C CZ  . PHE A 1 441 ? 88.972  113.258 118.975 1.00 86.08  ? 441 PHE A CZ  1 
ATOM   2972 N N   . PHE A 1 442 ? 84.005  114.946 113.616 1.00 75.01  ? 442 PHE A N   1 
ATOM   2973 C CA  . PHE A 1 442 ? 83.494  116.021 112.768 1.00 76.33  ? 442 PHE A CA  1 
ATOM   2974 C C   . PHE A 1 442 ? 82.328  115.563 111.875 1.00 85.77  ? 442 PHE A C   1 
ATOM   2975 O O   . PHE A 1 442 ? 82.291  114.428 111.414 1.00 109.70 ? 442 PHE A O   1 
ATOM   2976 C CB  . PHE A 1 442 ? 84.635  116.565 111.892 1.00 70.73  ? 442 PHE A CB  1 
ATOM   2977 C CG  . PHE A 1 442 ? 85.693  117.373 112.603 1.00 59.44  ? 442 PHE A CG  1 
ATOM   2978 C CD1 . PHE A 1 442 ? 85.404  118.628 113.116 1.00 69.43  ? 442 PHE A CD1 1 
ATOM   2979 C CD2 . PHE A 1 442 ? 86.984  116.887 112.757 1.00 50.41  ? 442 PHE A CD2 1 
ATOM   2980 C CE1 . PHE A 1 442 ? 86.373  119.370 113.785 1.00 65.43  ? 442 PHE A CE1 1 
ATOM   2981 C CE2 . PHE A 1 442 ? 87.946  117.622 113.424 1.00 50.01  ? 442 PHE A CE2 1 
ATOM   2982 C CZ  . PHE A 1 442 ? 87.642  118.865 113.935 1.00 57.79  ? 442 PHE A CZ  1 
ATOM   2983 N N   . GLN A 1 443 ? 81.385  116.475 111.591 1.00 72.11  ? 443 GLN A N   1 
ATOM   2984 C CA  . GLN A 1 443 ? 80.289  116.226 110.665 1.00 74.01  ? 443 GLN A CA  1 
ATOM   2985 C C   . GLN A 1 443 ? 80.780  116.117 109.221 1.00 83.56  ? 443 GLN A C   1 
ATOM   2986 O O   . GLN A 1 443 ? 81.853  116.595 108.895 1.00 98.99  ? 443 GLN A O   1 
ATOM   2987 C CB  . GLN A 1 443 ? 79.277  117.375 110.693 1.00 82.57  ? 443 GLN A CB  1 
ATOM   2988 C CG  . GLN A 1 443 ? 78.528  117.524 111.997 1.00 91.88  ? 443 GLN A CG  1 
ATOM   2989 C CD  . GLN A 1 443 ? 77.389  118.504 111.844 1.00 114.25 ? 443 GLN A CD  1 
ATOM   2990 O OE1 . GLN A 1 443 ? 76.217  118.130 111.830 1.00 150.27 ? 443 GLN A OE1 1 
ATOM   2991 N NE2 . GLN A 1 443 ? 77.723  119.776 111.702 1.00 111.61 ? 443 GLN A NE2 1 
ATOM   2992 N N   . GLN A 1 444 ? 79.919  115.623 108.324 1.00 100.67 ? 444 GLN A N   1 
ATOM   2993 C CA  . GLN A 1 444 ? 80.257  115.450 106.914 1.00 116.06 ? 444 GLN A CA  1 
ATOM   2994 C C   . GLN A 1 444 ? 80.541  116.787 106.210 1.00 94.20  ? 444 GLN A C   1 
ATOM   2995 O O   . GLN A 1 444 ? 81.245  116.798 105.197 1.00 85.65  ? 444 GLN A O   1 
ATOM   2996 C CB  . GLN A 1 444 ? 79.138  114.678 106.204 1.00 136.47 ? 444 GLN A CB  1 
ATOM   2997 C CG  . GLN A 1 444 ? 79.506  114.248 104.790 1.00 135.80 ? 444 GLN A CG  1 
ATOM   2998 C CD  . GLN A 1 444 ? 78.522  113.281 104.176 1.00 179.75 ? 444 GLN A CD  1 
ATOM   2999 O OE1 . GLN A 1 444 ? 77.421  113.062 104.676 1.00 195.65 ? 444 GLN A OE1 1 
ATOM   3000 N NE2 . GLN A 1 444 ? 78.917  112.687 103.063 1.00 209.32 ? 444 GLN A NE2 1 
ATOM   3001 N N   . SER A 1 445 ? 80.025  117.905 106.746 1.00 84.79  ? 445 SER A N   1 
ATOM   3002 C CA  . SER A 1 445 ? 80.296  119.236 106.212 1.00 93.12  ? 445 SER A CA  1 
ATOM   3003 C C   . SER A 1 445 ? 81.662  119.781 106.638 1.00 86.43  ? 445 SER A C   1 
ATOM   3004 O O   . SER A 1 445 ? 82.221  120.637 105.948 1.00 101.32 ? 445 SER A O   1 
ATOM   3005 C CB  . SER A 1 445 ? 79.218  120.211 106.607 1.00 101.74 ? 445 SER A CB  1 
ATOM   3006 O OG  . SER A 1 445 ? 79.294  120.520 107.984 1.00 102.42 ? 445 SER A OG  1 
ATOM   3007 N N   . GLN A 1 446 ? 82.180  119.297 107.782 1.00 76.84  ? 446 GLN A N   1 
ATOM   3008 C CA  . GLN A 1 446 ? 83.426  119.761 108.376 1.00 77.26  ? 446 GLN A CA  1 
ATOM   3009 C C   . GLN A 1 446 ? 84.612  118.864 108.011 1.00 62.35  ? 446 GLN A C   1 
ATOM   3010 O O   . GLN A 1 446 ? 85.768  119.298 108.037 1.00 65.24  ? 446 GLN A O   1 
ATOM   3011 C CB  . GLN A 1 446 ? 83.276  119.807 109.896 1.00 71.04  ? 446 GLN A CB  1 
ATOM   3012 C CG  . GLN A 1 446 ? 82.374  120.926 110.388 1.00 78.29  ? 446 GLN A CG  1 
ATOM   3013 C CD  . GLN A 1 446 ? 81.830  120.714 111.782 1.00 98.14  ? 446 GLN A CD  1 
ATOM   3014 O OE1 . GLN A 1 446 ? 81.975  119.656 112.393 1.00 101.27 ? 446 GLN A OE1 1 
ATOM   3015 N NE2 . GLN A 1 446 ? 81.135  121.723 112.283 1.00 109.90 ? 446 GLN A NE2 1 
ATOM   3016 N N   . ARG A 1 447 ? 84.323  117.617 107.639 1.00 58.85  ? 447 ARG A N   1 
ATOM   3017 C CA  . ARG A 1 447 ? 85.306  116.551 107.551 1.00 66.04  ? 447 ARG A CA  1 
ATOM   3018 C C   . ARG A 1 447 ? 86.313  116.826 106.441 1.00 68.94  ? 447 ARG A C   1 
ATOM   3019 O O   . ARG A 1 447 ? 87.490  116.537 106.634 1.00 88.21  ? 447 ARG A O   1 
ATOM   3020 C CB  . ARG A 1 447 ? 84.568  115.215 107.402 1.00 80.77  ? 447 ARG A CB  1 
ATOM   3021 C CG  . ARG A 1 447 ? 85.405  113.979 107.643 1.00 102.19 ? 447 ARG A CG  1 
ATOM   3022 C CD  . ARG A 1 447 ? 84.528  112.738 107.649 1.00 114.07 ? 447 ARG A CD  1 
ATOM   3023 N NE  . ARG A 1 447 ? 83.587  112.746 108.761 1.00 111.11 ? 447 ARG A NE  1 
ATOM   3024 C CZ  . ARG A 1 447 ? 82.505  111.978 108.836 1.00 129.21 ? 447 ARG A CZ  1 
ATOM   3025 N NH1 . ARG A 1 447 ? 81.681  112.080 109.866 1.00 137.87 ? 447 ARG A NH1 1 
ATOM   3026 N NH2 . ARG A 1 447 ? 82.240  111.116 107.870 1.00 145.62 ? 447 ARG A NH2 1 
ATOM   3027 N N   . PRO A 1 448 ? 85.944  117.369 105.254 1.00 82.52  ? 448 PRO A N   1 
ATOM   3028 C CA  . PRO A 1 448 ? 86.928  117.746 104.237 1.00 82.27  ? 448 PRO A CA  1 
ATOM   3029 C C   . PRO A 1 448 ? 87.989  118.727 104.722 1.00 78.16  ? 448 PRO A C   1 
ATOM   3030 O O   . PRO A 1 448 ? 89.158  118.555 104.396 1.00 87.87  ? 448 PRO A O   1 
ATOM   3031 C CB  . PRO A 1 448 ? 86.093  118.378 103.113 1.00 84.27  ? 448 PRO A CB  1 
ATOM   3032 C CG  . PRO A 1 448 ? 84.759  117.687 103.250 1.00 100.27 ? 448 PRO A CG  1 
ATOM   3033 C CD  . PRO A 1 448 ? 84.581  117.560 104.750 1.00 95.39  ? 448 PRO A CD  1 
ATOM   3034 N N   . ALA A 1 449 ? 87.596  119.730 105.514 1.00 77.35  ? 449 ALA A N   1 
ATOM   3035 C CA  . ALA A 1 449 ? 88.521  120.730 106.017 1.00 71.60  ? 449 ALA A CA  1 
ATOM   3036 C C   . ALA A 1 449 ? 89.377  120.163 107.145 1.00 66.41  ? 449 ALA A C   1 
ATOM   3037 O O   . ALA A 1 449 ? 90.557  120.490 107.234 1.00 83.57  ? 449 ALA A O   1 
ATOM   3038 C CB  . ALA A 1 449 ? 87.762  121.964 106.448 1.00 69.79  ? 449 ALA A CB  1 
ATOM   3039 N N   . ALA A 1 450 ? 88.807  119.309 107.999 1.00 68.89  ? 450 ALA A N   1 
ATOM   3040 C CA  . ALA A 1 450 ? 89.545  118.729 109.114 1.00 72.85  ? 450 ALA A CA  1 
ATOM   3041 C C   . ALA A 1 450 ? 90.741  117.914 108.624 1.00 64.41  ? 450 ALA A C   1 
ATOM   3042 O O   . ALA A 1 450 ? 91.795  117.942 109.253 1.00 82.49  ? 450 ALA A O   1 
ATOM   3043 C CB  . ALA A 1 450 ? 88.634  117.888 109.974 1.00 72.45  ? 450 ALA A CB  1 
ATOM   3044 N N   . PHE A 1 451 ? 90.607  117.197 107.505 1.00 60.09  ? 451 PHE A N   1 
ATOM   3045 C CA  . PHE A 1 451 ? 91.679  116.370 106.977 1.00 61.11  ? 451 PHE A CA  1 
ATOM   3046 C C   . PHE A 1 451 ? 92.747  117.189 106.242 1.00 72.64  ? 451 PHE A C   1 
ATOM   3047 O O   . PHE A 1 451 ? 93.865  116.694 106.075 1.00 79.64  ? 451 PHE A O   1 
ATOM   3048 C CB  . PHE A 1 451 ? 91.093  115.275 106.084 1.00 75.12  ? 451 PHE A CB  1 
ATOM   3049 C CG  . PHE A 1 451 ? 90.565  114.072 106.831 1.00 94.00  ? 451 PHE A CG  1 
ATOM   3050 C CD1 . PHE A 1 451 ? 91.438  113.256 107.532 1.00 114.42 ? 451 PHE A CD1 1 
ATOM   3051 C CD2 . PHE A 1 451 ? 89.216  113.734 106.814 1.00 92.08  ? 451 PHE A CD2 1 
ATOM   3052 C CE1 . PHE A 1 451 ? 90.972  112.132 108.196 1.00 117.20 ? 451 PHE A CE1 1 
ATOM   3053 C CE2 . PHE A 1 451 ? 88.746  112.631 107.505 1.00 96.64  ? 451 PHE A CE2 1 
ATOM   3054 C CZ  . PHE A 1 451 ? 89.630  111.817 108.162 1.00 114.06 ? 451 PHE A CZ  1 
ATOM   3055 N N   . ILE A 1 452 ? 92.456  118.437 105.834 1.00 69.51  ? 452 ILE A N   1 
ATOM   3056 C CA  . ILE A 1 452 ? 93.491  119.340 105.334 1.00 67.14  ? 452 ILE A CA  1 
ATOM   3057 C C   . ILE A 1 452 ? 94.372  119.800 106.503 1.00 68.56  ? 452 ILE A C   1 
ATOM   3058 O O   . ILE A 1 452 ? 95.591  119.773 106.382 1.00 76.86  ? 452 ILE A O   1 
ATOM   3059 C CB  . ILE A 1 452 ? 92.880  120.521 104.552 1.00 75.89  ? 452 ILE A CB  1 
ATOM   3060 C CG1 . ILE A 1 452 ? 92.267  120.019 103.249 1.00 95.80  ? 452 ILE A CG1 1 
ATOM   3061 C CG2 . ILE A 1 452 ? 93.902  121.618 104.290 1.00 83.01  ? 452 ILE A CG2 1 
ATOM   3062 C CD1 . ILE A 1 452 ? 91.341  121.029 102.579 1.00 129.26 ? 452 ILE A CD1 1 
ATOM   3063 N N   . ILE A 1 453 ? 93.774  120.192 107.639 1.00 59.63  ? 453 ILE A N   1 
ATOM   3064 C CA  . ILE A 1 453 ? 94.511  120.545 108.836 1.00 54.80  ? 453 ILE A CA  1 
ATOM   3065 C C   . ILE A 1 453 ? 95.350  119.350 109.281 1.00 55.59  ? 453 ILE A C   1 
ATOM   3066 O O   . ILE A 1 453 ? 96.557  119.478 109.455 1.00 58.52  ? 453 ILE A O   1 
ATOM   3067 C CB  . ILE A 1 453 ? 93.571  121.046 109.952 1.00 59.82  ? 453 ILE A CB  1 
ATOM   3068 C CG1 . ILE A 1 453 ? 92.879  122.348 109.557 1.00 69.13  ? 453 ILE A CG1 1 
ATOM   3069 C CG2 . ILE A 1 453 ? 94.294  121.214 111.270 1.00 65.91  ? 453 ILE A CG2 1 
ATOM   3070 C CD1 . ILE A 1 453 ? 91.808  122.807 110.522 1.00 77.22  ? 453 ILE A CD1 1 
ATOM   3071 N N   . ALA A 1 454 ? 94.713  118.196 109.492 1.00 58.55  ? 454 ALA A N   1 
ATOM   3072 C CA  . ALA A 1 454 ? 95.379  116.989 109.963 1.00 60.66  ? 454 ALA A CA  1 
ATOM   3073 C C   . ALA A 1 454 ? 96.532  116.573 109.041 1.00 67.98  ? 454 ALA A C   1 
ATOM   3074 O O   . ALA A 1 454 ? 97.611  116.239 109.523 1.00 76.10  ? 454 ALA A O   1 
ATOM   3075 C CB  . ALA A 1 454 ? 94.369  115.880 110.094 1.00 66.79  ? 454 ALA A CB  1 
ATOM   3076 N N   . GLY A 1 455 ? 96.322  116.602 107.718 1.00 62.38  ? 455 GLY A N   1 
ATOM   3077 C CA  . GLY A 1 455 ? 97.353  116.256 106.751 1.00 67.43  ? 455 GLY A CA  1 
ATOM   3078 C C   . GLY A 1 455 ? 98.508  117.260 106.693 1.00 64.47  ? 455 GLY A C   1 
ATOM   3079 O O   . GLY A 1 455 ? 99.660  116.862 106.614 1.00 68.05  ? 455 GLY A O   1 
ATOM   3080 N N   . THR A 1 456 ? 98.219  118.561 106.786 1.00 61.81  ? 456 THR A N   1 
ATOM   3081 C CA  . THR A 1 456 ? 99.263  119.574 106.820 1.00 63.58  ? 456 THR A CA  1 
ATOM   3082 C C   . THR A 1 456 ? 100.172 119.378 108.032 1.00 63.24  ? 456 THR A C   1 
ATOM   3083 O O   . THR A 1 456 ? 101.391 119.398 107.887 1.00 70.34  ? 456 THR A O   1 
ATOM   3084 C CB  . THR A 1 456 ? 98.679  120.994 106.809 1.00 64.49  ? 456 THR A CB  1 
ATOM   3085 O OG1 . THR A 1 456 ? 97.905  121.151 105.614 1.00 55.76  ? 456 THR A OG1 1 
ATOM   3086 C CG2 . THR A 1 456 ? 99.742  122.072 106.894 1.00 62.41  ? 456 THR A CG2 1 
ATOM   3087 N N   . VAL A 1 457 ? 99.585  119.189 109.223 1.00 65.43  ? 457 VAL A N   1 
ATOM   3088 C CA  . VAL A 1 457 ? 100.339 119.027 110.461 1.00 62.03  ? 457 VAL A CA  1 
ATOM   3089 C C   . VAL A 1 457 ? 101.159 117.733 110.440 1.00 56.58  ? 457 VAL A C   1 
ATOM   3090 O O   . VAL A 1 457 ? 102.244 117.680 111.013 1.00 64.47  ? 457 VAL A O   1 
ATOM   3091 C CB  . VAL A 1 457 ? 99.401  119.107 111.680 1.00 59.01  ? 457 VAL A CB  1 
ATOM   3092 C CG1 . VAL A 1 457 ? 100.099 118.759 112.978 1.00 55.27  ? 457 VAL A CG1 1 
ATOM   3093 C CG2 . VAL A 1 457 ? 98.778  120.489 111.784 1.00 74.74  ? 457 VAL A CG2 1 
ATOM   3094 N N   . ASN A 1 458 ? 100.652 116.700 109.766 1.00 55.94  ? 458 ASN A N   1 
ATOM   3095 C CA  . ASN A 1 458 ? 101.341 115.430 109.590 1.00 59.64  ? 458 ASN A CA  1 
ATOM   3096 C C   . ASN A 1 458 ? 102.646 115.596 108.803 1.00 56.22  ? 458 ASN A C   1 
ATOM   3097 O O   . ASN A 1 458 ? 103.717 115.252 109.294 1.00 56.56  ? 458 ASN A O   1 
ATOM   3098 C CB  . ASN A 1 458 ? 100.388 114.440 108.913 1.00 70.17  ? 458 ASN A CB  1 
ATOM   3099 C CG  . ASN A 1 458 ? 100.833 113.006 109.026 1.00 78.14  ? 458 ASN A CG  1 
ATOM   3100 O OD1 . ASN A 1 458 ? 101.753 112.587 108.325 1.00 97.46  ? 458 ASN A OD1 1 
ATOM   3101 N ND2 . ASN A 1 458 ? 100.188 112.256 109.904 1.00 86.86  ? 458 ASN A ND2 1 
ATOM   3102 N N   . TRP A 1 459 ? 102.579 116.171 107.593 1.00 55.74  ? 459 TRP A N   1 
ATOM   3103 C CA  . TRP A 1 459 ? 103.743 116.304 106.735 1.00 51.13  ? 459 TRP A CA  1 
ATOM   3104 C C   . TRP A 1 459 ? 104.768 117.316 107.270 1.00 53.99  ? 459 TRP A C   1 
ATOM   3105 O O   . TRP A 1 459 ? 105.963 117.079 107.161 1.00 59.06  ? 459 TRP A O   1 
ATOM   3106 C CB  . TRP A 1 459 ? 103.298 116.684 105.319 1.00 58.27  ? 459 TRP A CB  1 
ATOM   3107 C CG  . TRP A 1 459 ? 102.560 115.595 104.587 1.00 60.58  ? 459 TRP A CG  1 
ATOM   3108 C CD1 . TRP A 1 459 ? 101.244 115.615 104.240 1.00 60.64  ? 459 TRP A CD1 1 
ATOM   3109 C CD2 . TRP A 1 459 ? 103.091 114.349 104.074 1.00 63.69  ? 459 TRP A CD2 1 
ATOM   3110 N NE1 . TRP A 1 459 ? 100.908 114.471 103.574 1.00 59.82  ? 459 TRP A NE1 1 
ATOM   3111 C CE2 . TRP A 1 459 ? 102.019 113.680 103.446 1.00 62.29  ? 459 TRP A CE2 1 
ATOM   3112 C CE3 . TRP A 1 459 ? 104.352 113.738 104.080 1.00 64.66  ? 459 TRP A CE3 1 
ATOM   3113 C CZ2 . TRP A 1 459 ? 102.173 112.436 102.835 1.00 67.43  ? 459 TRP A CZ2 1 
ATOM   3114 C CZ3 . TRP A 1 459 ? 104.505 112.515 103.473 1.00 72.72  ? 459 TRP A CZ3 1 
ATOM   3115 C CH2 . TRP A 1 459 ? 103.427 111.874 102.854 1.00 75.32  ? 459 TRP A CH2 1 
ATOM   3116 N N   . LEU A 1 460 ? 104.323 118.429 107.869 1.00 50.35  ? 460 LEU A N   1 
ATOM   3117 C CA  . LEU A 1 460 ? 105.241 119.386 108.456 1.00 54.54  ? 460 LEU A CA  1 
ATOM   3118 C C   . LEU A 1 460 ? 105.979 118.794 109.666 1.00 57.91  ? 460 LEU A C   1 
ATOM   3119 O O   . LEU A 1 460 ? 107.085 119.239 109.982 1.00 69.75  ? 460 LEU A O   1 
ATOM   3120 C CB  . LEU A 1 460 ? 104.475 120.658 108.850 1.00 51.92  ? 460 LEU A CB  1 
ATOM   3121 C CG  . LEU A 1 460 ? 104.057 121.546 107.692 1.00 57.19  ? 460 LEU A CG  1 
ATOM   3122 C CD1 . LEU A 1 460 ? 103.309 122.771 108.186 1.00 63.54  ? 460 LEU A CD1 1 
ATOM   3123 C CD2 . LEU A 1 460 ? 105.257 121.946 106.851 1.00 64.29  ? 460 LEU A CD2 1 
ATOM   3124 N N   . SER A 1 461 ? 105.362 117.854 110.385 1.00 59.64  ? 461 SER A N   1 
ATOM   3125 C CA  . SER A 1 461 ? 105.992 117.218 111.526 1.00 63.92  ? 461 SER A CA  1 
ATOM   3126 C C   . SER A 1 461 ? 106.991 116.155 111.077 1.00 67.00  ? 461 SER A C   1 
ATOM   3127 O O   . SER A 1 461 ? 108.025 115.980 111.719 1.00 77.76  ? 461 SER A O   1 
ATOM   3128 C CB  . SER A 1 461 ? 104.954 116.610 112.449 1.00 66.83  ? 461 SER A CB  1 
ATOM   3129 O OG  . SER A 1 461 ? 104.101 117.611 112.961 1.00 71.63  ? 461 SER A OG  1 
ATOM   3130 N N   . ASN A 1 462 ? 106.670 115.423 110.008 1.00 65.83  ? 462 ASN A N   1 
ATOM   3131 C CA  . ASN A 1 462 ? 107.567 114.433 109.426 1.00 66.32  ? 462 ASN A CA  1 
ATOM   3132 C C   . ASN A 1 462 ? 108.838 115.103 108.878 1.00 64.78  ? 462 ASN A C   1 
ATOM   3133 O O   . ASN A 1 462 ? 109.942 114.584 109.041 1.00 66.72  ? 462 ASN A O   1 
ATOM   3134 C CB  . ASN A 1 462 ? 106.820 113.628 108.362 1.00 66.00  ? 462 ASN A CB  1 
ATOM   3135 C CG  . ASN A 1 462 ? 107.563 112.398 107.907 1.00 78.45  ? 462 ASN A CG  1 
ATOM   3136 O OD1 . ASN A 1 462 ? 108.542 111.993 108.528 1.00 90.42  ? 462 ASN A OD1 1 
ATOM   3137 N ND2 . ASN A 1 462 ? 107.094 111.785 106.834 1.00 95.99  ? 462 ASN A ND2 1 
ATOM   3138 N N   . PHE A 1 463 ? 108.686 116.265 108.241 1.00 61.23  ? 463 PHE A N   1 
ATOM   3139 C CA  . PHE A 1 463 ? 109.804 117.077 107.790 1.00 53.70  ? 463 PHE A CA  1 
ATOM   3140 C C   . PHE A 1 463 ? 110.723 117.450 108.957 1.00 56.15  ? 463 PHE A C   1 
ATOM   3141 O O   . PHE A 1 463 ? 111.930 117.276 108.863 1.00 70.90  ? 463 PHE A O   1 
ATOM   3142 C CB  . PHE A 1 463 ? 109.271 118.316 107.063 1.00 58.58  ? 463 PHE A CB  1 
ATOM   3143 C CG  . PHE A 1 463 ? 110.306 119.352 106.726 1.00 66.43  ? 463 PHE A CG  1 
ATOM   3144 C CD1 . PHE A 1 463 ? 111.261 119.091 105.761 1.00 65.47  ? 463 PHE A CD1 1 
ATOM   3145 C CD2 . PHE A 1 463 ? 110.346 120.564 107.402 1.00 69.99  ? 463 PHE A CD2 1 
ATOM   3146 C CE1 . PHE A 1 463 ? 112.240 120.025 105.461 1.00 68.75  ? 463 PHE A CE1 1 
ATOM   3147 C CE2 . PHE A 1 463 ? 111.330 121.493 107.100 1.00 75.95  ? 463 PHE A CE2 1 
ATOM   3148 C CZ  . PHE A 1 463 ? 112.255 121.228 106.110 1.00 71.20  ? 463 PHE A CZ  1 
ATOM   3149 N N   . ALA A 1 464 ? 110.181 117.964 110.066 1.00 60.64  ? 464 ALA A N   1 
ATOM   3150 C CA  . ALA A 1 464 ? 110.984 118.421 111.193 1.00 60.11  ? 464 ALA A CA  1 
ATOM   3151 C C   . ALA A 1 464 ? 111.786 117.281 111.831 1.00 64.29  ? 464 ALA A C   1 
ATOM   3152 O O   . ALA A 1 464 ? 112.950 117.480 112.181 1.00 80.77  ? 464 ALA A O   1 
ATOM   3153 C CB  . ALA A 1 464 ? 110.103 119.094 112.215 1.00 71.44  ? 464 ALA A CB  1 
ATOM   3154 N N   . VAL A 1 465 ? 111.201 116.086 111.961 1.00 63.46  ? 465 VAL A N   1 
ATOM   3155 C CA  . VAL A 1 465 ? 111.912 114.938 112.511 1.00 75.38  ? 465 VAL A CA  1 
ATOM   3156 C C   . VAL A 1 465 ? 113.030 114.514 111.561 1.00 62.90  ? 465 VAL A C   1 
ATOM   3157 O O   . VAL A 1 465 ? 114.144 114.265 111.993 1.00 74.92  ? 465 VAL A O   1 
ATOM   3158 C CB  . VAL A 1 465 ? 110.935 113.777 112.839 1.00 82.44  ? 465 VAL A CB  1 
ATOM   3159 C CG1 . VAL A 1 465 ? 111.584 112.403 112.949 1.00 78.94  ? 465 VAL A CG1 1 
ATOM   3160 C CG2 . VAL A 1 465 ? 110.175 114.087 114.107 1.00 83.98  ? 465 VAL A CG2 1 
ATOM   3161 N N   . GLY A 1 466 ? 112.734 114.384 110.267 1.00 71.20  ? 466 GLY A N   1 
ATOM   3162 C CA  . GLY A 1 466 ? 113.733 114.021 109.275 1.00 70.80  ? 466 GLY A CA  1 
ATOM   3163 C C   . GLY A 1 466 ? 114.901 115.004 109.219 1.00 64.21  ? 466 GLY A C   1 
ATOM   3164 O O   . GLY A 1 466 ? 116.029 114.578 108.989 1.00 67.47  ? 466 GLY A O   1 
ATOM   3165 N N   . LEU A 1 467 ? 114.625 116.308 109.385 1.00 62.53  ? 467 LEU A N   1 
ATOM   3166 C CA  . LEU A 1 467 ? 115.626 117.357 109.272 1.00 59.24  ? 467 LEU A CA  1 
ATOM   3167 C C   . LEU A 1 467 ? 116.470 117.493 110.544 1.00 61.97  ? 467 LEU A C   1 
ATOM   3168 O O   . LEU A 1 467 ? 117.675 117.700 110.448 1.00 72.42  ? 467 LEU A O   1 
ATOM   3169 C CB  . LEU A 1 467 ? 114.938 118.684 108.932 1.00 59.96  ? 467 LEU A CB  1 
ATOM   3170 C CG  . LEU A 1 467 ? 115.851 119.907 108.795 1.00 61.42  ? 467 LEU A CG  1 
ATOM   3171 C CD1 . LEU A 1 467 ? 116.620 119.877 107.502 1.00 68.29  ? 467 LEU A CD1 1 
ATOM   3172 C CD2 . LEU A 1 467 ? 115.052 121.192 108.832 1.00 69.39  ? 467 LEU A CD2 1 
ATOM   3173 N N   . LEU A 1 468 ? 115.860 117.439 111.734 1.00 67.46  ? 468 LEU A N   1 
ATOM   3174 C CA  . LEU A 1 468 ? 116.549 117.816 112.964 1.00 61.14  ? 468 LEU A CA  1 
ATOM   3175 C C   . LEU A 1 468 ? 117.214 116.637 113.691 1.00 61.59  ? 468 LEU A C   1 
ATOM   3176 O O   . LEU A 1 468 ? 118.128 116.876 114.474 1.00 58.55  ? 468 LEU A O   1 
ATOM   3177 C CB  . LEU A 1 468 ? 115.545 118.495 113.896 1.00 63.21  ? 468 LEU A CB  1 
ATOM   3178 C CG  . LEU A 1 468 ? 115.019 119.833 113.414 1.00 67.54  ? 468 LEU A CG  1 
ATOM   3179 C CD1 . LEU A 1 468 ? 113.947 120.350 114.364 1.00 84.70  ? 468 LEU A CD1 1 
ATOM   3180 C CD2 . LEU A 1 468 ? 116.172 120.813 113.316 1.00 76.75  ? 468 LEU A CD2 1 
ATOM   3181 N N   . PHE A 1 469 ? 116.820 115.382 113.435 1.00 60.26  ? 469 PHE A N   1 
ATOM   3182 C CA  . PHE A 1 469 ? 117.281 114.262 114.250 1.00 54.63  ? 469 PHE A CA  1 
ATOM   3183 C C   . PHE A 1 469 ? 118.810 114.162 114.247 1.00 54.50  ? 469 PHE A C   1 
ATOM   3184 O O   . PHE A 1 469 ? 119.398 113.985 115.313 1.00 53.53  ? 469 PHE A O   1 
ATOM   3185 C CB  . PHE A 1 469 ? 116.613 112.936 113.843 1.00 57.97  ? 469 PHE A CB  1 
ATOM   3186 C CG  . PHE A 1 469 ? 117.074 111.764 114.668 1.00 67.39  ? 469 PHE A CG  1 
ATOM   3187 C CD1 . PHE A 1 469 ? 116.726 111.645 116.004 1.00 77.78  ? 469 PHE A CD1 1 
ATOM   3188 C CD2 . PHE A 1 469 ? 117.937 110.824 114.140 1.00 73.62  ? 469 PHE A CD2 1 
ATOM   3189 C CE1 . PHE A 1 469 ? 117.196 110.597 116.776 1.00 77.83  ? 469 PHE A CE1 1 
ATOM   3190 C CE2 . PHE A 1 469 ? 118.405 109.774 114.906 1.00 69.78  ? 469 PHE A CE2 1 
ATOM   3191 C CZ  . PHE A 1 469 ? 118.027 109.659 116.218 1.00 80.16  ? 469 PHE A CZ  1 
ATOM   3192 N N   . PRO A 1 470 ? 119.537 114.257 113.099 1.00 58.55  ? 470 PRO A N   1 
ATOM   3193 C CA  . PRO A 1 470 ? 121.003 114.230 113.115 1.00 61.30  ? 470 PRO A CA  1 
ATOM   3194 C C   . PRO A 1 470 ? 121.694 115.309 113.949 1.00 67.57  ? 470 PRO A C   1 
ATOM   3195 O O   . PRO A 1 470 ? 122.838 115.106 114.363 1.00 75.50  ? 470 PRO A O   1 
ATOM   3196 C CB  . PRO A 1 470 ? 121.367 114.407 111.641 1.00 64.35  ? 470 PRO A CB  1 
ATOM   3197 C CG  . PRO A 1 470 ? 120.192 113.812 110.917 1.00 60.47  ? 470 PRO A CG  1 
ATOM   3198 C CD  . PRO A 1 470 ? 119.011 114.288 111.728 1.00 57.30  ? 470 PRO A CD  1 
ATOM   3199 N N   . PHE A 1 471 ? 121.004 116.430 114.218 1.00 65.03  ? 471 PHE A N   1 
ATOM   3200 C CA  . PHE A 1 471 ? 121.536 117.501 115.051 1.00 71.70  ? 471 PHE A CA  1 
ATOM   3201 C C   . PHE A 1 471 ? 121.241 117.260 116.529 1.00 70.89  ? 471 PHE A C   1 
ATOM   3202 O O   . PHE A 1 471 ? 122.024 117.677 117.385 1.00 82.87  ? 471 PHE A O   1 
ATOM   3203 C CB  . PHE A 1 471 ? 121.006 118.847 114.562 1.00 83.66  ? 471 PHE A CB  1 
ATOM   3204 C CG  . PHE A 1 471 ? 121.473 119.200 113.170 1.00 106.50 ? 471 PHE A CG  1 
ATOM   3205 C CD1 . PHE A 1 471 ? 122.763 119.669 112.966 1.00 110.87 ? 471 PHE A CD1 1 
ATOM   3206 C CD2 . PHE A 1 471 ? 120.651 119.007 112.066 1.00 102.53 ? 471 PHE A CD2 1 
ATOM   3207 C CE1 . PHE A 1 471 ? 123.210 119.976 111.695 1.00 97.44  ? 471 PHE A CE1 1 
ATOM   3208 C CE2 . PHE A 1 471 ? 121.097 119.311 110.795 1.00 101.04 ? 471 PHE A CE2 1 
ATOM   3209 C CZ  . PHE A 1 471 ? 122.367 119.810 110.625 1.00 112.33 ? 471 PHE A CZ  1 
ATOM   3210 N N   . ILE A 1 472 ? 120.126 116.584 116.826 1.00 72.24  ? 472 ILE A N   1 
ATOM   3211 C CA  . ILE A 1 472 ? 119.810 116.153 118.186 1.00 66.98  ? 472 ILE A CA  1 
ATOM   3212 C C   . ILE A 1 472 ? 120.795 115.057 118.606 1.00 70.52  ? 472 ILE A C   1 
ATOM   3213 O O   . ILE A 1 472 ? 121.297 115.102 119.721 1.00 83.86  ? 472 ILE A O   1 
ATOM   3214 C CB  . ILE A 1 472 ? 118.334 115.709 118.296 1.00 64.74  ? 472 ILE A CB  1 
ATOM   3215 C CG1 . ILE A 1 472 ? 117.355 116.827 117.962 1.00 84.46  ? 472 ILE A CG1 1 
ATOM   3216 C CG2 . ILE A 1 472 ? 118.025 115.136 119.649 1.00 68.04  ? 472 ILE A CG2 1 
ATOM   3217 C CD1 . ILE A 1 472 ? 115.929 116.318 117.746 1.00 100.91 ? 472 ILE A CD1 1 
ATOM   3218 N N   . GLN A 1 473 ? 121.101 114.095 117.718 1.00 71.50  ? 473 GLN A N   1 
ATOM   3219 C CA  . GLN A 1 473 ? 122.122 113.081 117.958 1.00 73.52  ? 473 GLN A CA  1 
ATOM   3220 C C   . GLN A 1 473 ? 123.511 113.685 118.181 1.00 84.81  ? 473 GLN A C   1 
ATOM   3221 O O   . GLN A 1 473 ? 124.303 113.137 118.938 1.00 90.44  ? 473 GLN A O   1 
ATOM   3222 C CB  . GLN A 1 473 ? 122.258 112.139 116.765 1.00 76.88  ? 473 GLN A CB  1 
ATOM   3223 C CG  . GLN A 1 473 ? 121.184 111.083 116.669 1.00 88.95  ? 473 GLN A CG  1 
ATOM   3224 C CD  . GLN A 1 473 ? 121.694 109.902 115.879 1.00 102.55 ? 473 GLN A CD  1 
ATOM   3225 O OE1 . GLN A 1 473 ? 122.011 110.017 114.696 1.00 94.97  ? 473 GLN A OE1 1 
ATOM   3226 N NE2 . GLN A 1 473 ? 121.806 108.764 116.550 1.00 110.42 ? 473 GLN A NE2 1 
ATOM   3227 N N   . LYS A 1 474 ? 123.834 114.773 117.473 1.00 94.32  ? 474 LYS A N   1 
ATOM   3228 C CA  . LYS A 1 474 ? 125.116 115.436 117.623 1.00 103.82 ? 474 LYS A CA  1 
ATOM   3229 C C   . LYS A 1 474 ? 125.204 116.099 119.001 1.00 94.60  ? 474 LYS A C   1 
ATOM   3230 O O   . LYS A 1 474 ? 126.242 116.024 119.657 1.00 93.49  ? 474 LYS A O   1 
ATOM   3231 C CB  . LYS A 1 474 ? 125.306 116.457 116.493 1.00 122.17 ? 474 LYS A CB  1 
ATOM   3232 C CG  . LYS A 1 474 ? 126.683 117.103 116.425 1.00 146.71 ? 474 LYS A CG  1 
ATOM   3233 C CD  . LYS A 1 474 ? 126.707 118.375 115.600 1.00 175.03 ? 474 LYS A CD  1 
ATOM   3234 C CE  . LYS A 1 474 ? 128.039 119.094 115.639 1.00 200.23 ? 474 LYS A CE  1 
ATOM   3235 N NZ  . LYS A 1 474 ? 129.004 118.524 114.667 1.00 211.94 ? 474 LYS A NZ  1 
ATOM   3236 N N   . SER A 1 475 ? 124.117 116.771 119.415 1.00 93.93  ? 475 SER A N   1 
ATOM   3237 C CA  . SER A 1 475 ? 124.111 117.666 120.563 1.00 97.80  ? 475 SER A CA  1 
ATOM   3238 C C   . SER A 1 475 ? 123.968 116.916 121.886 1.00 87.57  ? 475 SER A C   1 
ATOM   3239 O O   . SER A 1 475 ? 124.739 117.165 122.813 1.00 109.44 ? 475 SER A O   1 
ATOM   3240 C CB  . SER A 1 475 ? 123.017 118.692 120.422 1.00 115.81 ? 475 SER A CB  1 
ATOM   3241 O OG  . SER A 1 475 ? 123.159 119.421 119.208 1.00 140.44 ? 475 SER A OG  1 
ATOM   3242 N N   . LEU A 1 476 ? 122.957 116.047 121.987 1.00 87.41  ? 476 LEU A N   1 
ATOM   3243 C CA  . LEU A 1 476 ? 122.659 115.320 123.216 1.00 84.52  ? 476 LEU A CA  1 
ATOM   3244 C C   . LEU A 1 476 ? 123.404 113.982 123.283 1.00 90.59  ? 476 LEU A C   1 
ATOM   3245 O O   . LEU A 1 476 ? 123.378 113.340 124.326 1.00 95.85  ? 476 LEU A O   1 
ATOM   3246 C CB  . LEU A 1 476 ? 121.146 115.075 123.293 1.00 75.58  ? 476 LEU A CB  1 
ATOM   3247 C CG  . LEU A 1 476 ? 120.314 116.296 123.612 1.00 72.21  ? 476 LEU A CG  1 
ATOM   3248 C CD1 . LEU A 1 476 ? 118.833 115.955 123.554 1.00 78.92  ? 476 LEU A CD1 1 
ATOM   3249 C CD2 . LEU A 1 476 ? 120.724 116.792 124.985 1.00 75.16  ? 476 LEU A CD2 1 
ATOM   3250 N N   . ASP A 1 477 ? 124.000 113.551 122.168 1.00 93.04  ? 477 ASP A N   1 
ATOM   3251 C CA  . ASP A 1 477 ? 124.784 112.329 122.105 1.00 94.15  ? 477 ASP A CA  1 
ATOM   3252 C C   . ASP A 1 477 ? 123.905 111.132 122.443 1.00 79.40  ? 477 ASP A C   1 
ATOM   3253 O O   . ASP A 1 477 ? 123.082 110.712 121.620 1.00 83.37  ? 477 ASP A O   1 
ATOM   3254 C CB  . ASP A 1 477 ? 126.057 112.443 122.947 1.00 117.18 ? 477 ASP A CB  1 
ATOM   3255 C CG  . ASP A 1 477 ? 126.963 111.238 122.817 1.00 145.83 ? 477 ASP A CG  1 
ATOM   3256 O OD1 . ASP A 1 477 ? 127.640 111.108 121.772 1.00 155.16 ? 477 ASP A OD1 1 
ATOM   3257 O OD2 . ASP A 1 477 ? 126.955 110.427 123.757 1.00 171.18 ? 477 ASP A OD2 1 
ATOM   3258 N N   . THR A 1 478 ? 124.082 110.573 123.645 1.00 94.33  ? 478 THR A N   1 
ATOM   3259 C CA  . THR A 1 478 ? 123.425 109.330 124.041 1.00 93.00  ? 478 THR A CA  1 
ATOM   3260 C C   . THR A 1 478 ? 122.016 109.567 124.596 1.00 77.38  ? 478 THR A C   1 
ATOM   3261 O O   . THR A 1 478 ? 121.223 108.636 124.662 1.00 82.64  ? 478 THR A O   1 
ATOM   3262 C CB  . THR A 1 478 ? 124.295 108.584 125.047 1.00 100.44 ? 478 THR A CB  1 
ATOM   3263 O OG1 . THR A 1 478 ? 125.564 108.295 124.462 1.00 108.79 ? 478 THR A OG1 1 
ATOM   3264 C CG2 . THR A 1 478 ? 123.657 107.285 125.433 1.00 108.10 ? 478 THR A CG2 1 
ATOM   3265 N N   . TYR A 1 479 ? 121.690 110.818 124.974 1.00 78.30  ? 479 TYR A N   1 
ATOM   3266 C CA  . TYR A 1 479 ? 120.390 111.148 125.538 1.00 72.20  ? 479 TYR A CA  1 
ATOM   3267 C C   . TYR A 1 479 ? 119.396 111.645 124.484 1.00 69.50  ? 479 TYR A C   1 
ATOM   3268 O O   . TYR A 1 479 ? 118.349 112.169 124.840 1.00 78.91  ? 479 TYR A O   1 
ATOM   3269 C CB  . TYR A 1 479 ? 120.604 112.214 126.609 1.00 67.03  ? 479 TYR A CB  1 
ATOM   3270 C CG  . TYR A 1 479 ? 121.519 111.767 127.733 1.00 66.45  ? 479 TYR A CG  1 
ATOM   3271 C CD1 . TYR A 1 479 ? 121.073 110.948 128.759 1.00 72.88  ? 479 TYR A CD1 1 
ATOM   3272 C CD2 . TYR A 1 479 ? 122.837 112.171 127.758 1.00 75.68  ? 479 TYR A CD2 1 
ATOM   3273 C CE1 . TYR A 1 479 ? 121.912 110.563 129.793 1.00 80.64  ? 479 TYR A CE1 1 
ATOM   3274 C CE2 . TYR A 1 479 ? 123.694 111.772 128.772 1.00 102.94 ? 479 TYR A CE2 1 
ATOM   3275 C CZ  . TYR A 1 479 ? 123.236 110.958 129.790 1.00 86.42  ? 479 TYR A CZ  1 
ATOM   3276 O OH  . TYR A 1 479 ? 124.124 110.608 130.767 1.00 86.29  ? 479 TYR A OH  1 
ATOM   3277 N N   . CYS A 1 480 ? 119.681 111.437 123.199 1.00 79.48  ? 480 CYS A N   1 
ATOM   3278 C CA  . CYS A 1 480 ? 118.881 112.007 122.120 1.00 77.64  ? 480 CYS A CA  1 
ATOM   3279 C C   . CYS A 1 480 ? 117.449 111.483 122.149 1.00 75.69  ? 480 CYS A C   1 
ATOM   3280 O O   . CYS A 1 480 ? 116.546 112.162 121.655 1.00 90.92  ? 480 CYS A O   1 
ATOM   3281 C CB  . CYS A 1 480 ? 119.511 111.719 120.759 1.00 88.12  ? 480 CYS A CB  1 
ATOM   3282 S SG  . CYS A 1 480 ? 119.976 109.981 120.544 1.00 106.85 ? 480 CYS A SG  1 
ATOM   3283 N N   . PHE A 1 481 ? 117.214 110.295 122.729 1.00 80.02  ? 481 PHE A N   1 
ATOM   3284 C CA  . PHE A 1 481 ? 115.868 109.727 122.744 1.00 76.22  ? 481 PHE A CA  1 
ATOM   3285 C C   . PHE A 1 481 ? 115.021 110.276 123.902 1.00 69.72  ? 481 PHE A C   1 
ATOM   3286 O O   . PHE A 1 481 ? 113.817 110.048 123.908 1.00 80.72  ? 481 PHE A O   1 
ATOM   3287 C CB  . PHE A 1 481 ? 115.945 108.198 122.762 1.00 78.54  ? 481 PHE A CB  1 
ATOM   3288 C CG  . PHE A 1 481 ? 116.405 107.646 121.448 1.00 83.84  ? 481 PHE A CG  1 
ATOM   3289 C CD1 . PHE A 1 481 ? 115.566 107.679 120.349 1.00 87.49  ? 481 PHE A CD1 1 
ATOM   3290 C CD2 . PHE A 1 481 ? 117.704 107.189 121.281 1.00 93.87  ? 481 PHE A CD2 1 
ATOM   3291 C CE1 . PHE A 1 481 ? 116.007 107.245 119.109 1.00 84.16  ? 481 PHE A CE1 1 
ATOM   3292 C CE2 . PHE A 1 481 ? 118.128 106.718 120.047 1.00 83.05  ? 481 PHE A CE2 1 
ATOM   3293 C CZ  . PHE A 1 481 ? 117.280 106.750 118.971 1.00 78.01  ? 481 PHE A CZ  1 
ATOM   3294 N N   . LEU A 1 482 ? 115.594 111.030 124.850 1.00 57.64  ? 482 LEU A N   1 
ATOM   3295 C CA  . LEU A 1 482 ? 114.779 111.655 125.879 1.00 58.56  ? 482 LEU A CA  1 
ATOM   3296 C C   . LEU A 1 482 ? 113.887 112.756 125.293 1.00 61.89  ? 482 LEU A C   1 
ATOM   3297 O O   . LEU A 1 482 ? 112.896 113.135 125.921 1.00 78.57  ? 482 LEU A O   1 
ATOM   3298 C CB  . LEU A 1 482 ? 115.650 112.203 127.011 1.00 57.99  ? 482 LEU A CB  1 
ATOM   3299 C CG  . LEU A 1 482 ? 116.327 111.149 127.874 1.00 66.84  ? 482 LEU A CG  1 
ATOM   3300 C CD1 . LEU A 1 482 ? 117.089 111.775 129.027 1.00 76.08  ? 482 LEU A CD1 1 
ATOM   3301 C CD2 . LEU A 1 482 ? 115.318 110.137 128.384 1.00 76.09  ? 482 LEU A CD2 1 
ATOM   3302 N N   . VAL A 1 483 ? 114.213 113.266 124.103 1.00 61.40  ? 483 VAL A N   1 
ATOM   3303 C CA  . VAL A 1 483 ? 113.355 114.210 123.401 1.00 68.71  ? 483 VAL A CA  1 
ATOM   3304 C C   . VAL A 1 483 ? 112.046 113.516 123.020 1.00 63.77  ? 483 VAL A C   1 
ATOM   3305 O O   . VAL A 1 483 ? 110.970 114.026 123.316 1.00 82.73  ? 483 VAL A O   1 
ATOM   3306 C CB  . VAL A 1 483 ? 114.081 114.814 122.182 1.00 71.61  ? 483 VAL A CB  1 
ATOM   3307 C CG1 . VAL A 1 483 ? 113.151 115.635 121.305 1.00 89.46  ? 483 VAL A CG1 1 
ATOM   3308 C CG2 . VAL A 1 483 ? 115.280 115.648 122.619 1.00 65.43  ? 483 VAL A CG2 1 
ATOM   3309 N N   . PHE A 1 484 ? 112.135 112.332 122.408 1.00 67.18  ? 484 PHE A N   1 
ATOM   3310 C CA  . PHE A 1 484 ? 110.969 111.589 121.960 1.00 71.88  ? 484 PHE A CA  1 
ATOM   3311 C C   . PHE A 1 484 ? 110.205 110.950 123.128 1.00 70.25  ? 484 PHE A C   1 
ATOM   3312 O O   . PHE A 1 484 ? 108.986 110.803 123.050 1.00 78.16  ? 484 PHE A O   1 
ATOM   3313 C CB  . PHE A 1 484 ? 111.386 110.546 120.923 1.00 77.53  ? 484 PHE A CB  1 
ATOM   3314 C CG  . PHE A 1 484 ? 112.063 111.094 119.692 1.00 90.25  ? 484 PHE A CG  1 
ATOM   3315 C CD1 . PHE A 1 484 ? 111.717 112.327 119.173 1.00 107.96 ? 484 PHE A CD1 1 
ATOM   3316 C CD2 . PHE A 1 484 ? 113.019 110.349 119.022 1.00 108.97 ? 484 PHE A CD2 1 
ATOM   3317 C CE1 . PHE A 1 484 ? 112.333 112.817 118.033 1.00 127.70 ? 484 PHE A CE1 1 
ATOM   3318 C CE2 . PHE A 1 484 ? 113.630 110.838 117.879 1.00 115.39 ? 484 PHE A CE2 1 
ATOM   3319 C CZ  . PHE A 1 484 ? 113.282 112.070 117.385 1.00 118.58 ? 484 PHE A CZ  1 
ATOM   3320 N N   . ALA A 1 485 ? 110.894 110.593 124.217 1.00 61.09  ? 485 ALA A N   1 
ATOM   3321 C CA  . ALA A 1 485 ? 110.231 110.216 125.455 1.00 62.91  ? 485 ALA A CA  1 
ATOM   3322 C C   . ALA A 1 485 ? 109.364 111.358 125.973 1.00 69.74  ? 485 ALA A C   1 
ATOM   3323 O O   . ALA A 1 485 ? 108.220 111.133 126.370 1.00 80.78  ? 485 ALA A O   1 
ATOM   3324 C CB  . ALA A 1 485 ? 111.248 109.806 126.492 1.00 75.30  ? 485 ALA A CB  1 
ATOM   3325 N N   . THR A 1 486 ? 109.900 112.589 125.980 1.00 83.68  ? 486 THR A N   1 
ATOM   3326 C CA  . THR A 1 486 ? 109.188 113.754 126.498 1.00 76.69  ? 486 THR A CA  1 
ATOM   3327 C C   . THR A 1 486 ? 107.965 114.081 125.647 1.00 72.90  ? 486 THR A C   1 
ATOM   3328 O O   . THR A 1 486 ? 106.924 114.436 126.197 1.00 102.86 ? 486 THR A O   1 
ATOM   3329 C CB  . THR A 1 486 ? 110.107 114.969 126.630 1.00 70.69  ? 486 THR A CB  1 
ATOM   3330 O OG1 . THR A 1 486 ? 111.190 114.629 127.494 1.00 82.04  ? 486 THR A OG1 1 
ATOM   3331 C CG2 . THR A 1 486 ? 109.405 116.160 127.233 1.00 84.27  ? 486 THR A CG2 1 
ATOM   3332 N N   . ILE A 1 487 ? 108.073 113.923 124.327 1.00 72.78  ? 487 ILE A N   1 
ATOM   3333 C CA  . ILE A 1 487 ? 106.966 114.177 123.409 1.00 80.76  ? 487 ILE A CA  1 
ATOM   3334 C C   . ILE A 1 487 ? 105.882 113.096 123.535 1.00 75.66  ? 487 ILE A C   1 
ATOM   3335 O O   . ILE A 1 487 ? 104.700 113.429 123.571 1.00 70.18  ? 487 ILE A O   1 
ATOM   3336 C CB  . ILE A 1 487 ? 107.501 114.353 121.968 1.00 75.37  ? 487 ILE A CB  1 
ATOM   3337 C CG1 . ILE A 1 487 ? 108.252 115.680 121.853 1.00 88.82  ? 487 ILE A CG1 1 
ATOM   3338 C CG2 . ILE A 1 487 ? 106.405 114.253 120.929 1.00 72.53  ? 487 ILE A CG2 1 
ATOM   3339 C CD1 . ILE A 1 487 ? 109.137 115.808 120.637 1.00 93.51  ? 487 ILE A CD1 1 
ATOM   3340 N N   . CYS A 1 488 ? 106.268 111.817 123.646 1.00 78.06  ? 488 CYS A N   1 
ATOM   3341 C CA  . CYS A 1 488 ? 105.302 110.743 123.829 1.00 74.81  ? 488 CYS A CA  1 
ATOM   3342 C C   . CYS A 1 488 ? 104.529 110.899 125.139 1.00 68.51  ? 488 CYS A C   1 
ATOM   3343 O O   . CYS A 1 488 ? 103.310 110.765 125.150 1.00 87.33  ? 488 CYS A O   1 
ATOM   3344 C CB  . CYS A 1 488 ? 105.978 109.380 123.772 1.00 71.67  ? 488 CYS A CB  1 
ATOM   3345 S SG  . CYS A 1 488 ? 106.509 108.950 122.099 1.00 91.21  ? 488 CYS A SG  1 
ATOM   3346 N N   . ILE A 1 489 ? 105.219 111.205 126.241 1.00 65.35  ? 489 ILE A N   1 
ATOM   3347 C CA  . ILE A 1 489 ? 104.567 111.316 127.532 1.00 69.85  ? 489 ILE A CA  1 
ATOM   3348 C C   . ILE A 1 489 ? 103.720 112.590 127.585 1.00 83.83  ? 489 ILE A C   1 
ATOM   3349 O O   . ILE A 1 489 ? 102.628 112.572 128.150 1.00 97.57  ? 489 ILE A O   1 
ATOM   3350 C CB  . ILE A 1 489 ? 105.596 111.205 128.676 1.00 82.83  ? 489 ILE A CB  1 
ATOM   3351 C CG1 . ILE A 1 489 ? 106.192 109.797 128.729 1.00 99.50  ? 489 ILE A CG1 1 
ATOM   3352 C CG2 . ILE A 1 489 ? 104.994 111.601 130.016 1.00 83.63  ? 489 ILE A CG2 1 
ATOM   3353 C CD1 . ILE A 1 489 ? 107.431 109.692 129.598 1.00 124.62 ? 489 ILE A CD1 1 
ATOM   3354 N N   . THR A 1 490 ? 104.172 113.699 126.980 1.00 82.03  ? 490 THR A N   1 
ATOM   3355 C CA  . THR A 1 490 ? 103.384 114.928 126.956 1.00 81.93  ? 490 THR A CA  1 
ATOM   3356 C C   . THR A 1 490 ? 102.116 114.766 126.115 1.00 81.82  ? 490 THR A C   1 
ATOM   3357 O O   . THR A 1 490 ? 101.064 115.297 126.478 1.00 101.53 ? 490 THR A O   1 
ATOM   3358 C CB  . THR A 1 490 ? 104.215 116.116 126.467 1.00 86.31  ? 490 THR A CB  1 
ATOM   3359 O OG1 . THR A 1 490 ? 105.288 116.287 127.390 1.00 92.32  ? 490 THR A OG1 1 
ATOM   3360 C CG2 . THR A 1 490 ? 103.433 117.409 126.396 1.00 106.13 ? 490 THR A CG2 1 
ATOM   3361 N N   . GLY A 1 491 ? 102.215 114.032 125.000 1.00 78.38  ? 491 GLY A N   1 
ATOM   3362 C CA  . GLY A 1 491 ? 101.059 113.682 124.189 1.00 74.39  ? 491 GLY A CA  1 
ATOM   3363 C C   . GLY A 1 491 ? 100.079 112.772 124.934 1.00 83.40  ? 491 GLY A C   1 
ATOM   3364 O O   . GLY A 1 491 ? 98.882  112.997 124.892 1.00 89.31  ? 491 GLY A O   1 
ATOM   3365 N N   . ALA A 1 492 ? 100.588 111.736 125.611 1.00 82.68  ? 492 ALA A N   1 
ATOM   3366 C CA  . ALA A 1 492 ? 99.769  110.798 126.358 1.00 69.88  ? 492 ALA A CA  1 
ATOM   3367 C C   . ALA A 1 492 ? 99.028  111.496 127.492 1.00 65.46  ? 492 ALA A C   1 
ATOM   3368 O O   . ALA A 1 492 ? 97.865  111.189 127.738 1.00 82.52  ? 492 ALA A O   1 
ATOM   3369 C CB  . ALA A 1 492 ? 100.633 109.679 126.903 1.00 86.15  ? 492 ALA A CB  1 
ATOM   3370 N N   . ILE A 1 493 ? 99.685  112.393 128.236 1.00 65.56  ? 493 ILE A N   1 
ATOM   3371 C CA  . ILE A 1 493 ? 99.048  113.078 129.354 1.00 70.36  ? 493 ILE A CA  1 
ATOM   3372 C C   . ILE A 1 493 ? 97.946  114.014 128.839 1.00 70.12  ? 493 ILE A C   1 
ATOM   3373 O O   . ILE A 1 493 ? 96.882  114.073 129.442 1.00 73.83  ? 493 ILE A O   1 
ATOM   3374 C CB  . ILE A 1 493 ? 100.075 113.812 130.234 1.00 73.81  ? 493 ILE A CB  1 
ATOM   3375 C CG1 . ILE A 1 493 ? 101.013 112.837 130.941 1.00 88.02  ? 493 ILE A CG1 1 
ATOM   3376 C CG2 . ILE A 1 493 ? 99.380  114.711 131.243 1.00 69.29  ? 493 ILE A CG2 1 
ATOM   3377 C CD1 . ILE A 1 493 ? 102.264 113.505 131.516 1.00 95.85  ? 493 ILE A CD1 1 
ATOM   3378 N N   . TYR A 1 494 ? 98.169  114.719 127.723 1.00 63.24  ? 494 TYR A N   1 
ATOM   3379 C CA  . TYR A 1 494 ? 97.127  115.527 127.099 1.00 66.25  ? 494 TYR A CA  1 
ATOM   3380 C C   . TYR A 1 494 ? 95.883  114.679 126.793 1.00 65.04  ? 494 TYR A C   1 
ATOM   3381 O O   . TYR A 1 494 ? 94.783  115.011 127.216 1.00 71.08  ? 494 TYR A O   1 
ATOM   3382 C CB  . TYR A 1 494 ? 97.663  116.213 125.830 1.00 75.32  ? 494 TYR A CB  1 
ATOM   3383 C CG  . TYR A 1 494 ? 96.568  116.900 125.030 1.00 59.69  ? 494 TYR A CG  1 
ATOM   3384 C CD1 . TYR A 1 494 ? 96.105  118.152 125.384 1.00 64.57  ? 494 TYR A CD1 1 
ATOM   3385 C CD2 . TYR A 1 494 ? 95.937  116.247 123.991 1.00 69.35  ? 494 TYR A CD2 1 
ATOM   3386 C CE1 . TYR A 1 494 ? 95.075  118.758 124.693 1.00 75.83  ? 494 TYR A CE1 1 
ATOM   3387 C CE2 . TYR A 1 494 ? 94.886  116.829 123.301 1.00 82.67  ? 494 TYR A CE2 1 
ATOM   3388 C CZ  . TYR A 1 494 ? 94.463  118.096 123.650 1.00 79.55  ? 494 TYR A CZ  1 
ATOM   3389 O OH  . TYR A 1 494 ? 93.427  118.674 122.980 1.00 85.34  ? 494 TYR A OH  1 
ATOM   3390 N N   . LEU A 1 495 ? 96.049  113.569 126.065 1.00 62.78  ? 495 LEU A N   1 
ATOM   3391 C CA  . LEU A 1 495 ? 94.933  112.739 125.645 1.00 56.03  ? 495 LEU A CA  1 
ATOM   3392 C C   . LEU A 1 495 ? 94.215  112.104 126.839 1.00 64.56  ? 495 LEU A C   1 
ATOM   3393 O O   . LEU A 1 495 ? 93.012  111.923 126.769 1.00 84.92  ? 495 LEU A O   1 
ATOM   3394 C CB  . LEU A 1 495 ? 95.422  111.670 124.668 1.00 52.66  ? 495 LEU A CB  1 
ATOM   3395 C CG  . LEU A 1 495 ? 95.891  112.202 123.319 1.00 60.29  ? 495 LEU A CG  1 
ATOM   3396 C CD1 . LEU A 1 495 ? 96.469  111.090 122.457 1.00 62.30  ? 495 LEU A CD1 1 
ATOM   3397 C CD2 . LEU A 1 495 ? 94.773  112.894 122.570 1.00 64.84  ? 495 LEU A CD2 1 
ATOM   3398 N N   . TYR A 1 496 ? 94.898  111.811 127.947 1.00 61.57  ? 496 TYR A N   1 
ATOM   3399 C CA  . TYR A 1 496 ? 94.226  111.293 129.124 1.00 59.48  ? 496 TYR A CA  1 
ATOM   3400 C C   . TYR A 1 496 ? 93.196  112.295 129.658 1.00 65.76  ? 496 TYR A C   1 
ATOM   3401 O O   . TYR A 1 496 ? 92.103  111.896 130.066 1.00 81.22  ? 496 TYR A O   1 
ATOM   3402 C CB  . TYR A 1 496 ? 95.232  110.870 130.188 1.00 65.30  ? 496 TYR A CB  1 
ATOM   3403 C CG  . TYR A 1 496 ? 94.544  110.430 131.472 1.00 71.50  ? 496 TYR A CG  1 
ATOM   3404 C CD1 . TYR A 1 496 ? 94.079  109.139 131.630 1.00 82.18  ? 496 TYR A CD1 1 
ATOM   3405 C CD2 . TYR A 1 496 ? 94.299  111.338 132.496 1.00 90.80  ? 496 TYR A CD2 1 
ATOM   3406 C CE1 . TYR A 1 496 ? 93.416  108.752 132.783 1.00 100.81 ? 496 TYR A CE1 1 
ATOM   3407 C CE2 . TYR A 1 496 ? 93.645  110.963 133.656 1.00 104.51 ? 496 TYR A CE2 1 
ATOM   3408 C CZ  . TYR A 1 496 ? 93.193  109.666 133.796 1.00 108.41 ? 496 TYR A CZ  1 
ATOM   3409 O OH  . TYR A 1 496 ? 92.542  109.283 134.935 1.00 135.58 ? 496 TYR A OH  1 
ATOM   3410 N N   . PHE A 1 497 ? 93.515  113.597 129.648 1.00 68.60  ? 497 PHE A N   1 
ATOM   3411 C CA  . PHE A 1 497 ? 92.637  114.627 130.199 1.00 80.84  ? 497 PHE A CA  1 
ATOM   3412 C C   . PHE A 1 497 ? 91.566  115.122 129.219 1.00 79.87  ? 497 PHE A C   1 
ATOM   3413 O O   . PHE A 1 497 ? 90.463  115.437 129.662 1.00 87.54  ? 497 PHE A O   1 
ATOM   3414 C CB  . PHE A 1 497 ? 93.457  115.809 130.718 1.00 82.14  ? 497 PHE A CB  1 
ATOM   3415 C CG  . PHE A 1 497 ? 94.157  115.527 132.027 1.00 96.11  ? 497 PHE A CG  1 
ATOM   3416 C CD1 . PHE A 1 497 ? 93.428  115.374 133.185 1.00 106.08 ? 497 PHE A CD1 1 
ATOM   3417 C CD2 . PHE A 1 497 ? 95.530  115.391 132.102 1.00 105.95 ? 497 PHE A CD2 1 
ATOM   3418 C CE1 . PHE A 1 497 ? 94.055  115.135 134.394 1.00 110.07 ? 497 PHE A CE1 1 
ATOM   3419 C CE2 . PHE A 1 497 ? 96.155  115.116 133.300 1.00 118.31 ? 497 PHE A CE2 1 
ATOM   3420 C CZ  . PHE A 1 497 ? 95.415  115.001 134.446 1.00 124.00 ? 497 PHE A CZ  1 
ATOM   3421 N N   . VAL A 1 498 ? 91.859  115.193 127.904 1.00 73.23  ? 498 VAL A N   1 
ATOM   3422 C CA  . VAL A 1 498 ? 90.944  115.822 126.957 1.00 73.47  ? 498 VAL A CA  1 
ATOM   3423 C C   . VAL A 1 498 ? 90.074  114.795 126.222 1.00 81.82  ? 498 VAL A C   1 
ATOM   3424 O O   . VAL A 1 498 ? 88.864  115.012 126.106 1.00 101.91 ? 498 VAL A O   1 
ATOM   3425 C CB  . VAL A 1 498 ? 91.681  116.737 125.964 1.00 79.50  ? 498 VAL A CB  1 
ATOM   3426 C CG1 . VAL A 1 498 ? 90.797  117.197 124.813 1.00 95.00  ? 498 VAL A CG1 1 
ATOM   3427 C CG2 . VAL A 1 498 ? 92.263  117.941 126.680 1.00 87.49  ? 498 VAL A CG2 1 
ATOM   3428 N N   . LEU A 1 499 ? 90.664  113.707 125.711 1.00 67.68  ? 499 LEU A N   1 
ATOM   3429 C CA  . LEU A 1 499 ? 90.028  112.865 124.699 1.00 69.39  ? 499 LEU A CA  1 
ATOM   3430 C C   . LEU A 1 499 ? 88.831  112.101 125.271 1.00 80.95  ? 499 LEU A C   1 
ATOM   3431 O O   . LEU A 1 499 ? 88.991  111.308 126.197 1.00 98.15  ? 499 LEU A O   1 
ATOM   3432 C CB  . LEU A 1 499 ? 91.099  111.903 124.171 1.00 59.39  ? 499 LEU A CB  1 
ATOM   3433 C CG  . LEU A 1 499 ? 90.667  110.891 123.129 1.00 67.48  ? 499 LEU A CG  1 
ATOM   3434 C CD1 . LEU A 1 499 ? 90.404  111.570 121.821 1.00 79.27  ? 499 LEU A CD1 1 
ATOM   3435 C CD2 . LEU A 1 499 ? 91.716  109.812 122.949 1.00 80.50  ? 499 LEU A CD2 1 
ATOM   3436 N N   . PRO A 1 500 ? 87.590  112.277 124.738 1.00 85.64  ? 500 PRO A N   1 
ATOM   3437 C CA  . PRO A 1 500 ? 86.452  111.464 125.164 1.00 88.32  ? 500 PRO A CA  1 
ATOM   3438 C C   . PRO A 1 500 ? 86.439  110.114 124.460 1.00 91.15  ? 500 PRO A C   1 
ATOM   3439 O O   . PRO A 1 500 ? 86.962  109.988 123.356 1.00 91.57  ? 500 PRO A O   1 
ATOM   3440 C CB  . PRO A 1 500 ? 85.245  112.313 124.760 1.00 86.32  ? 500 PRO A CB  1 
ATOM   3441 C CG  . PRO A 1 500 ? 85.716  113.017 123.522 1.00 92.70  ? 500 PRO A CG  1 
ATOM   3442 C CD  . PRO A 1 500 ? 87.198  113.269 123.729 1.00 89.98  ? 500 PRO A CD  1 
ATOM   3443 N N   . GLU A 1 501 ? 85.827  109.113 125.113 1.00 94.31  ? 501 GLU A N   1 
ATOM   3444 C CA  . GLU A 1 501 ? 85.683  107.786 124.536 1.00 95.36  ? 501 GLU A CA  1 
ATOM   3445 C C   . GLU A 1 501 ? 84.750  107.849 123.329 1.00 93.35  ? 501 GLU A C   1 
ATOM   3446 O O   . GLU A 1 501 ? 83.629  108.342 123.452 1.00 101.50 ? 501 GLU A O   1 
ATOM   3447 C CB  . GLU A 1 501 ? 85.145  106.821 125.597 1.00 116.89 ? 501 GLU A CB  1 
ATOM   3448 C CG  . GLU A 1 501 ? 85.015  105.382 125.123 1.00 138.23 ? 501 GLU A CG  1 
ATOM   3449 C CD  . GLU A 1 501 ? 86.292  104.770 124.565 1.00 138.62 ? 501 GLU A CD  1 
ATOM   3450 O OE1 . GLU A 1 501 ? 86.630  105.060 123.398 1.00 121.48 ? 501 GLU A OE1 1 
ATOM   3451 O OE2 . GLU A 1 501 ? 86.945  104.018 125.311 1.00 134.54 ? 501 GLU A OE2 1 
ATOM   3452 N N   . THR A 1 502 ? 85.200  107.318 122.178 1.00 95.35  ? 502 THR A N   1 
ATOM   3453 C CA  . THR A 1 502 ? 84.451  107.419 120.929 1.00 100.72 ? 502 THR A CA  1 
ATOM   3454 C C   . THR A 1 502 ? 83.990  106.063 120.390 1.00 105.08 ? 502 THR A C   1 
ATOM   3455 O O   . THR A 1 502 ? 83.158  106.040 119.489 1.00 114.03 ? 502 THR A O   1 
ATOM   3456 C CB  . THR A 1 502 ? 85.250  108.110 119.809 1.00 112.55 ? 502 THR A CB  1 
ATOM   3457 O OG1 . THR A 1 502 ? 86.405  107.327 119.497 1.00 99.72  ? 502 THR A OG1 1 
ATOM   3458 C CG2 . THR A 1 502 ? 85.683  109.522 120.145 1.00 113.39 ? 502 THR A CG2 1 
ATOM   3459 N N   . LYS A 1 503 ? 84.486  104.933 120.917 1.00 126.24 ? 503 LYS A N   1 
ATOM   3460 C CA  . LYS A 1 503 ? 84.112  103.630 120.374 1.00 126.36 ? 503 LYS A CA  1 
ATOM   3461 C C   . LYS A 1 503 ? 82.620  103.368 120.605 1.00 141.20 ? 503 LYS A C   1 
ATOM   3462 O O   . LYS A 1 503 ? 82.144  103.487 121.735 1.00 143.19 ? 503 LYS A O   1 
ATOM   3463 C CB  . LYS A 1 503 ? 84.922  102.496 121.012 1.00 123.22 ? 503 LYS A CB  1 
ATOM   3464 C CG  . LYS A 1 503 ? 84.965  101.228 120.172 1.00 140.14 ? 503 LYS A CG  1 
ATOM   3465 C CD  . LYS A 1 503 ? 85.118  99.953  120.971 1.00 160.33 ? 503 LYS A CD  1 
ATOM   3466 C CE  . LYS A 1 503 ? 85.185  98.725  120.090 1.00 179.94 ? 503 LYS A CE  1 
ATOM   3467 N NZ  . LYS A 1 503 ? 85.080  97.476  120.883 1.00 196.89 ? 503 LYS A NZ  1 
ATOM   3468 N N   . ASN A 1 504 ? 81.906  103.010 119.518 1.00 142.60 ? 504 ASN A N   1 
ATOM   3469 C CA  . ASN A 1 504 ? 80.481  102.692 119.513 1.00 140.54 ? 504 ASN A CA  1 
ATOM   3470 C C   . ASN A 1 504 ? 79.611  103.890 119.911 1.00 127.90 ? 504 ASN A C   1 
ATOM   3471 O O   . ASN A 1 504 ? 78.470  103.690 120.333 1.00 133.67 ? 504 ASN A O   1 
ATOM   3472 C CB  . ASN A 1 504 ? 80.164  101.472 120.392 1.00 149.99 ? 504 ASN A CB  1 
ATOM   3473 C CG  . ASN A 1 504 ? 80.822  100.192 119.915 1.00 164.33 ? 504 ASN A CG  1 
ATOM   3474 O OD1 . ASN A 1 504 ? 81.125  100.038 118.732 1.00 173.16 ? 504 ASN A OD1 1 
ATOM   3475 N ND2 . ASN A 1 504 ? 81.032  99.265  120.835 1.00 158.93 ? 504 ASN A ND2 1 
ATOM   3476 N N   . ARG A 1 505 ? 80.099  105.131 119.719 1.00 116.07 ? 505 ARG A N   1 
ATOM   3477 C CA  . ARG A 1 505 ? 79.363  106.316 120.144 1.00 113.15 ? 505 ARG A CA  1 
ATOM   3478 C C   . ARG A 1 505 ? 79.102  107.275 118.977 1.00 125.38 ? 505 ARG A C   1 
ATOM   3479 O O   . ARG A 1 505 ? 79.871  107.362 118.016 1.00 135.98 ? 505 ARG A O   1 
ATOM   3480 C CB  . ARG A 1 505 ? 80.087  107.023 121.292 1.00 110.91 ? 505 ARG A CB  1 
ATOM   3481 C CG  . ARG A 1 505 ? 80.220  106.164 122.542 1.00 131.23 ? 505 ARG A CG  1 
ATOM   3482 C CD  . ARG A 1 505 ? 79.892  106.929 123.810 1.00 146.79 ? 505 ARG A CD  1 
ATOM   3483 N NE  . ARG A 1 505 ? 80.846  107.995 124.056 1.00 165.83 ? 505 ARG A NE  1 
ATOM   3484 C CZ  . ARG A 1 505 ? 80.636  109.045 124.845 1.00 197.20 ? 505 ARG A CZ  1 
ATOM   3485 N NH1 . ARG A 1 505 ? 81.628  109.886 125.091 1.00 206.68 ? 505 ARG A NH1 1 
ATOM   3486 N NH2 . ARG A 1 505 ? 79.450  109.246 125.399 1.00 191.42 ? 505 ARG A NH2 1 
ATOM   3487 N N   . THR A 1 506 ? 77.990  108.018 119.101 1.00 116.24 ? 506 THR A N   1 
ATOM   3488 C CA  . THR A 1 506 ? 77.460  108.866 118.043 1.00 126.01 ? 506 THR A CA  1 
ATOM   3489 C C   . THR A 1 506 ? 78.038  110.281 118.123 1.00 114.52 ? 506 THR A C   1 
ATOM   3490 O O   . THR A 1 506 ? 78.490  110.704 119.184 1.00 109.91 ? 506 THR A O   1 
ATOM   3491 C CB  . THR A 1 506 ? 75.928  108.913 118.122 1.00 150.75 ? 506 THR A CB  1 
ATOM   3492 O OG1 . THR A 1 506 ? 75.550  109.230 119.461 1.00 129.57 ? 506 THR A OG1 1 
ATOM   3493 C CG2 . THR A 1 506 ? 75.274  107.611 117.716 1.00 171.65 ? 506 THR A CG2 1 
ATOM   3494 N N   . TYR A 1 507 ? 77.983  111.026 117.005 1.00 100.71 ? 507 TYR A N   1 
ATOM   3495 C CA  . TYR A 1 507 ? 78.447  112.406 116.967 1.00 97.95  ? 507 TYR A CA  1 
ATOM   3496 C C   . TYR A 1 507 ? 77.702  113.247 118.005 1.00 90.19  ? 507 TYR A C   1 
ATOM   3497 O O   . TYR A 1 507 ? 78.276  114.159 118.602 1.00 111.07 ? 507 TYR A O   1 
ATOM   3498 C CB  . TYR A 1 507 ? 78.312  112.991 115.553 1.00 119.28 ? 507 TYR A CB  1 
ATOM   3499 C CG  . TYR A 1 507 ? 78.563  114.493 115.514 1.00 111.76 ? 507 TYR A CG  1 
ATOM   3500 C CD1 . TYR A 1 507 ? 79.853  115.014 115.514 1.00 108.00 ? 507 TYR A CD1 1 
ATOM   3501 C CD2 . TYR A 1 507 ? 77.502  115.389 115.556 1.00 113.99 ? 507 TYR A CD2 1 
ATOM   3502 C CE1 . TYR A 1 507 ? 80.070  116.382 115.526 1.00 128.11 ? 507 TYR A CE1 1 
ATOM   3503 C CE2 . TYR A 1 507 ? 77.709  116.759 115.558 1.00 122.47 ? 507 TYR A CE2 1 
ATOM   3504 C CZ  . TYR A 1 507 ? 78.998  117.257 115.553 1.00 133.31 ? 507 TYR A CZ  1 
ATOM   3505 O OH  . TYR A 1 507 ? 79.235  118.606 115.568 1.00 150.87 ? 507 TYR A OH  1 
ATOM   3506 N N   . ALA A 1 508 ? 76.418  112.937 118.224 1.00 99.96  ? 508 ALA A N   1 
ATOM   3507 C CA  . ALA A 1 508 ? 75.571  113.650 119.179 1.00 114.73 ? 508 ALA A CA  1 
ATOM   3508 C C   . ALA A 1 508 ? 76.062  113.504 120.626 1.00 113.18 ? 508 ALA A C   1 
ATOM   3509 O O   . ALA A 1 508 ? 75.792  114.378 121.443 1.00 120.18 ? 508 ALA A O   1 
ATOM   3510 C CB  . ALA A 1 508 ? 74.149  113.163 119.030 1.00 128.25 ? 508 ALA A CB  1 
ATOM   3511 N N   . GLU A 1 509 ? 76.762  112.404 120.948 1.00 116.05 ? 509 GLU A N   1 
ATOM   3512 C CA  . GLU A 1 509 ? 77.320  112.178 122.276 1.00 118.81 ? 509 GLU A CA  1 
ATOM   3513 C C   . GLU A 1 509 ? 78.748  112.714 122.383 1.00 100.25 ? 509 GLU A C   1 
ATOM   3514 O O   . GLU A 1 509 ? 79.108  113.299 123.399 1.00 104.07 ? 509 GLU A O   1 
ATOM   3515 C CB  . GLU A 1 509 ? 77.317  110.685 122.621 1.00 159.98 ? 509 GLU A CB  1 
ATOM   3516 C CG  . GLU A 1 509 ? 75.944  110.138 122.975 1.00 194.99 ? 509 GLU A CG  1 
ATOM   3517 C CD  . GLU A 1 509 ? 75.965  108.783 123.670 1.00 231.28 ? 509 GLU A CD  1 
ATOM   3518 O OE1 . GLU A 1 509 ? 76.859  108.569 124.519 1.00 239.14 ? 509 GLU A OE1 1 
ATOM   3519 O OE2 . GLU A 1 509 ? 75.070  107.953 123.398 1.00 251.90 ? 509 GLU A OE2 1 
ATOM   3520 N N   . ILE A 1 510 ? 79.570  112.498 121.345 1.00 98.63  ? 510 ILE A N   1 
ATOM   3521 C CA  . ILE A 1 510 ? 80.969  112.907 121.349 1.00 84.67  ? 510 ILE A CA  1 
ATOM   3522 C C   . ILE A 1 510 ? 81.069  114.436 121.362 1.00 86.87  ? 510 ILE A C   1 
ATOM   3523 O O   . ILE A 1 510 ? 81.857  114.989 122.129 1.00 95.99  ? 510 ILE A O   1 
ATOM   3524 C CB  . ILE A 1 510 ? 81.731  112.293 120.156 1.00 85.73  ? 510 ILE A CB  1 
ATOM   3525 C CG1 . ILE A 1 510 ? 81.760  110.766 120.233 1.00 89.46  ? 510 ILE A CG1 1 
ATOM   3526 C CG2 . ILE A 1 510 ? 83.135  112.884 120.040 1.00 83.22  ? 510 ILE A CG2 1 
ATOM   3527 C CD1 . ILE A 1 510 ? 82.098  110.091 118.911 1.00 98.23  ? 510 ILE A CD1 1 
ATOM   3528 N N   . SER A 1 511 ? 80.255  115.129 120.552 1.00 85.22  ? 511 SER A N   1 
ATOM   3529 C CA  . SER A 1 511 ? 80.260  116.584 120.531 1.00 100.84 ? 511 SER A CA  1 
ATOM   3530 C C   . SER A 1 511 ? 79.765  117.161 121.861 1.00 98.92  ? 511 SER A C   1 
ATOM   3531 O O   . SER A 1 511 ? 80.245  118.212 122.296 1.00 114.00 ? 511 SER A O   1 
ATOM   3532 C CB  . SER A 1 511 ? 79.479  117.126 119.360 1.00 102.84 ? 511 SER A CB  1 
ATOM   3533 O OG  . SER A 1 511 ? 78.119  116.748 119.444 1.00 118.54 ? 511 SER A OG  1 
ATOM   3534 N N   . GLN A 1 512 ? 78.835  116.467 122.524 1.00 98.34  ? 512 GLN A N   1 
ATOM   3535 C CA  . GLN A 1 512 ? 78.353  116.883 123.835 1.00 110.30 ? 512 GLN A CA  1 
ATOM   3536 C C   . GLN A 1 512 ? 79.440  116.680 124.894 1.00 103.98 ? 512 GLN A C   1 
ATOM   3537 O O   . GLN A 1 512 ? 79.556  117.506 125.797 1.00 126.66 ? 512 GLN A O   1 
ATOM   3538 C CB  . GLN A 1 512 ? 77.038  116.174 124.178 1.00 137.46 ? 512 GLN A CB  1 
ATOM   3539 C CG  . GLN A 1 512 ? 76.240  116.854 125.286 1.00 149.92 ? 512 GLN A CG  1 
ATOM   3540 C CD  . GLN A 1 512 ? 76.658  116.443 126.678 1.00 175.60 ? 512 GLN A CD  1 
ATOM   3541 O OE1 . GLN A 1 512 ? 77.337  115.436 126.878 1.00 182.67 ? 512 GLN A OE1 1 
ATOM   3542 N NE2 . GLN A 1 512 ? 76.229  117.214 127.665 1.00 193.17 ? 512 GLN A NE2 1 
ATOM   3543 N N   . ALA A 1 513 ? 80.277  115.638 124.765 1.00 102.71 ? 513 ALA A N   1 
ATOM   3544 C CA  . ALA A 1 513 ? 81.396  115.413 125.678 1.00 102.48 ? 513 ALA A CA  1 
ATOM   3545 C C   . ALA A 1 513 ? 82.456  116.518 125.572 1.00 116.91 ? 513 ALA A C   1 
ATOM   3546 O O   . ALA A 1 513 ? 82.994  116.941 126.590 1.00 130.74 ? 513 ALA A O   1 
ATOM   3547 C CB  . ALA A 1 513 ? 82.002  114.051 125.436 1.00 98.15  ? 513 ALA A CB  1 
ATOM   3548 N N   . PHE A 1 514 ? 82.763  116.991 124.352 1.00 109.89 ? 514 PHE A N   1 
ATOM   3549 C CA  . PHE A 1 514 ? 83.664  118.123 124.158 1.00 91.74  ? 514 PHE A CA  1 
ATOM   3550 C C   . PHE A 1 514 ? 83.037  119.452 124.600 1.00 88.12  ? 514 PHE A C   1 
ATOM   3551 O O   . PHE A 1 514 ? 83.774  120.356 124.988 1.00 97.57  ? 514 PHE A O   1 
ATOM   3552 C CB  . PHE A 1 514 ? 84.104  118.227 122.698 1.00 76.17  ? 514 PHE A CB  1 
ATOM   3553 C CG  . PHE A 1 514 ? 85.226  117.315 122.267 1.00 69.98  ? 514 PHE A CG  1 
ATOM   3554 C CD1 . PHE A 1 514 ? 86.522  117.536 122.677 1.00 76.10  ? 514 PHE A CD1 1 
ATOM   3555 C CD2 . PHE A 1 514 ? 85.000  116.275 121.382 1.00 74.00  ? 514 PHE A CD2 1 
ATOM   3556 C CE1 . PHE A 1 514 ? 87.553  116.710 122.251 1.00 78.92  ? 514 PHE A CE1 1 
ATOM   3557 C CE2 . PHE A 1 514 ? 86.030  115.464 120.935 1.00 62.82  ? 514 PHE A CE2 1 
ATOM   3558 C CZ  . PHE A 1 514 ? 87.307  115.677 121.379 1.00 69.08  ? 514 PHE A CZ  1 
ATOM   3559 N N   . SER A 1 515 ? 81.699  119.573 124.578 1.00 96.96  ? 515 SER A N   1 
ATOM   3560 C CA  . SER A 1 515 ? 81.017  120.848 124.803 1.00 110.38 ? 515 SER A CA  1 
ATOM   3561 C C   . SER A 1 515 ? 81.294  121.436 126.193 1.00 119.46 ? 515 SER A C   1 
ATOM   3562 O O   . SER A 1 515 ? 81.141  122.644 126.382 1.00 126.23 ? 515 SER A O   1 
ATOM   3563 C CB  . SER A 1 515 ? 79.524  120.737 124.571 1.00 124.33 ? 515 SER A CB  1 
ATOM   3564 O OG  . SER A 1 515 ? 78.869  120.095 125.660 1.00 133.71 ? 515 SER A OG  1 
ATOM   3565 N N   . LYS A 1 516 ? 81.722  120.605 127.157 1.00 118.74 ? 516 LYS A N   1 
ATOM   3566 C CA  . LYS A 1 516 ? 82.029  121.062 128.504 1.00 141.87 ? 516 LYS A CA  1 
ATOM   3567 C C   . LYS A 1 516 ? 83.238  122.005 128.540 1.00 131.17 ? 516 LYS A C   1 
ATOM   3568 O O   . LYS A 1 516 ? 83.390  122.756 129.506 1.00 138.56 ? 516 LYS A O   1 
ATOM   3569 C CB  . LYS A 1 516 ? 82.268  119.858 129.421 1.00 174.17 ? 516 LYS A CB  1 
ATOM   3570 C CG  . LYS A 1 516 ? 81.027  119.034 129.738 1.00 206.84 ? 516 LYS A CG  1 
ATOM   3571 C CD  . LYS A 1 516 ? 80.017  119.765 130.607 1.00 228.83 ? 516 LYS A CD  1 
ATOM   3572 C CE  . LYS A 1 516 ? 78.814  118.922 130.979 1.00 250.73 ? 516 LYS A CE  1 
ATOM   3573 N NZ  . LYS A 1 516 ? 79.159  117.829 131.921 1.00 257.13 ? 516 LYS A NZ  1 
ATOM   3574 N N   . ARG A 1 517 ? 84.107  121.955 127.512 1.00 115.71 ? 517 ARG A N   1 
ATOM   3575 C CA  . ARG A 1 517 ? 85.311  122.780 127.465 1.00 104.26 ? 517 ARG A CA  1 
ATOM   3576 C C   . ARG A 1 517 ? 85.323  123.739 126.266 1.00 104.51 ? 517 ARG A C   1 
ATOM   3577 O O   . ARG A 1 517 ? 86.015  124.758 126.314 1.00 113.23 ? 517 ARG A O   1 
ATOM   3578 C CB  . ARG A 1 517 ? 86.573  121.906 127.513 1.00 97.51  ? 517 ARG A CB  1 
ATOM   3579 C CG  . ARG A 1 517 ? 86.649  120.812 126.464 1.00 102.72 ? 517 ARG A CG  1 
ATOM   3580 C CD  . ARG A 1 517 ? 87.991  120.104 126.491 1.00 129.13 ? 517 ARG A CD  1 
ATOM   3581 N NE  . ARG A 1 517 ? 88.200  119.322 127.708 1.00 134.28 ? 517 ARG A NE  1 
ATOM   3582 C CZ  . ARG A 1 517 ? 89.012  119.663 128.703 1.00 126.50 ? 517 ARG A CZ  1 
ATOM   3583 N NH1 . ARG A 1 517 ? 89.202  118.831 129.712 1.00 130.16 ? 517 ARG A NH1 1 
ATOM   3584 N NH2 . ARG A 1 517 ? 89.657  120.819 128.685 1.00 131.46 ? 517 ARG A NH2 1 
ATOM   3585 N N   . ASN A 1 518 ? 84.546  123.457 125.207 1.00 101.32 ? 518 ASN A N   1 
ATOM   3586 C CA  . ASN A 1 518 ? 84.308  124.418 124.136 1.00 87.28  ? 518 ASN A CA  1 
ATOM   3587 C C   . ASN A 1 518 ? 83.526  125.623 124.666 1.00 101.83 ? 518 ASN A C   1 
ATOM   3588 O O   . ASN A 1 518 ? 83.762  126.742 124.204 1.00 127.06 ? 518 ASN A O   1 
ATOM   3589 C CB  . ASN A 1 518 ? 83.561  123.780 122.961 1.00 81.72  ? 518 ASN A CB  1 
ATOM   3590 C CG  . ASN A 1 518 ? 84.391  122.831 122.127 1.00 79.36  ? 518 ASN A CG  1 
ATOM   3591 O OD1 . ASN A 1 518 ? 85.604  122.946 122.064 1.00 78.68  ? 518 ASN A OD1 1 
ATOM   3592 N ND2 . ASN A 1 518 ? 83.741  121.909 121.441 1.00 100.02 ? 518 ASN A ND2 1 
ATOM   3593 N N   . LYS A 1 519 ? 82.575  125.380 125.587 1.00 115.93 ? 519 LYS A N   1 
ATOM   3594 C CA  . LYS A 1 519 ? 81.716  126.395 126.197 1.00 151.84 ? 519 LYS A CA  1 
ATOM   3595 C C   . LYS A 1 519 ? 80.874  127.139 125.151 1.00 165.39 ? 519 LYS A C   1 
ATOM   3596 O O   . LYS A 1 519 ? 80.415  128.258 125.403 1.00 165.48 ? 519 LYS A O   1 
ATOM   3597 C CB  . LYS A 1 519 ? 82.539  127.362 127.058 1.00 178.06 ? 519 LYS A CB  1 
ATOM   3598 C CG  . LYS A 1 519 ? 83.214  126.738 128.273 1.00 199.55 ? 519 LYS A CG  1 
ATOM   3599 C CD  . LYS A 1 519 ? 84.080  127.711 129.044 1.00 214.09 ? 519 LYS A CD  1 
ATOM   3600 C CE  . LYS A 1 519 ? 84.859  127.054 130.162 1.00 219.70 ? 519 LYS A CE  1 
ATOM   3601 N NZ  . LYS A 1 519 ? 85.748  128.022 130.847 1.00 222.30 ? 519 LYS A NZ  1 
ATOM   3602 N N   . ALA A 1 520 ? 80.601  126.476 124.014 1.00 181.48 ? 520 ALA A N   1 
ATOM   3603 C CA  . ALA A 1 520 ? 79.890  127.076 122.891 1.00 214.70 ? 520 ALA A CA  1 
ATOM   3604 C C   . ALA A 1 520 ? 79.198  125.991 122.061 1.00 233.20 ? 520 ALA A C   1 
ATOM   3605 O O   . ALA A 1 520 ? 79.558  124.816 122.147 1.00 226.30 ? 520 ALA A O   1 
ATOM   3606 C CB  . ALA A 1 520 ? 80.853  127.881 122.049 1.00 215.50 ? 520 ALA A CB  1 
ATOM   3607 N N   . TYR A 1 521 ? 78.211  126.408 121.247 1.00 247.75 ? 521 TYR A N   1 
ATOM   3608 C CA  . TYR A 1 521 ? 77.400  125.504 120.437 1.00 249.73 ? 521 TYR A CA  1 
ATOM   3609 C C   . TYR A 1 521 ? 77.180  126.096 119.041 1.00 231.04 ? 521 TYR A C   1 
ATOM   3610 O O   . TYR A 1 521 ? 77.208  127.314 118.873 1.00 229.31 ? 521 TYR A O   1 
ATOM   3611 C CB  . TYR A 1 521 ? 76.057  125.258 121.136 1.00 263.23 ? 521 TYR A CB  1 
ATOM   3612 C CG  . TYR A 1 521 ? 76.143  124.737 122.567 1.00 270.18 ? 521 TYR A CG  1 
ATOM   3613 C CD1 . TYR A 1 521 ? 76.232  123.375 122.844 1.00 287.49 ? 521 TYR A CD1 1 
ATOM   3614 C CD2 . TYR A 1 521 ? 76.154  125.617 123.644 1.00 266.16 ? 521 TYR A CD2 1 
ATOM   3615 C CE1 . TYR A 1 521 ? 76.324  122.907 124.147 1.00 295.90 ? 521 TYR A CE1 1 
ATOM   3616 C CE2 . TYR A 1 521 ? 76.242  125.162 124.950 1.00 277.21 ? 521 TYR A CE2 1 
ATOM   3617 C CZ  . TYR A 1 521 ? 76.325  123.803 125.203 1.00 288.99 ? 521 TYR A CZ  1 
ATOM   3618 O OH  . TYR A 1 521 ? 76.411  123.353 126.491 1.00 283.01 ? 521 TYR A OH  1 
ATOM   3619 N N   . PRO A 1 522 ? 76.944  125.261 117.997 1.00 223.02 ? 522 PRO A N   1 
ATOM   3620 C CA  . PRO A 1 522 ? 76.731  125.759 116.633 1.00 223.72 ? 522 PRO A CA  1 
ATOM   3621 C C   . PRO A 1 522 ? 75.679  126.877 116.504 1.00 213.86 ? 522 PRO A C   1 
ATOM   3622 O O   . PRO A 1 522 ? 74.515  126.638 116.790 1.00 204.24 ? 522 PRO A O   1 
ATOM   3623 C CB  . PRO A 1 522 ? 76.296  124.499 115.866 1.00 232.97 ? 522 PRO A CB  1 
ATOM   3624 C CG  . PRO A 1 522 ? 76.989  123.370 116.605 1.00 235.35 ? 522 PRO A CG  1 
ATOM   3625 C CD  . PRO A 1 522 ? 76.916  123.789 118.059 1.00 224.75 ? 522 PRO A CD  1 
HETATM 3626 C C1  . NAG B 2 .   ? 135.568 114.410 103.087 1.00 104.69 ? 1   NAG B C1  1 
HETATM 3627 C C2  . NAG B 2 .   ? 135.553 114.227 104.601 1.00 123.75 ? 1   NAG B C2  1 
HETATM 3628 C C3  . NAG B 2 .   ? 136.972 114.100 105.164 1.00 150.14 ? 1   NAG B C3  1 
HETATM 3629 C C4  . NAG B 2 .   ? 137.783 113.058 104.401 1.00 164.40 ? 1   NAG B C4  1 
HETATM 3630 C C5  . NAG B 2 .   ? 137.763 113.402 102.915 1.00 155.42 ? 1   NAG B C5  1 
HETATM 3631 C C6  . NAG B 2 .   ? 138.491 112.391 102.043 1.00 175.94 ? 1   NAG B C6  1 
HETATM 3632 C C7  . NAG B 2 .   ? 133.759 115.164 106.022 1.00 128.55 ? 1   NAG B C7  1 
HETATM 3633 C C8  . NAG B 2 .   ? 133.228 116.409 106.666 1.00 134.42 ? 1   NAG B C8  1 
HETATM 3634 N N2  . NAG B 2 .   ? 134.842 115.316 105.249 1.00 126.29 ? 1   NAG B N2  1 
HETATM 3635 O O3  . NAG B 2 .   ? 136.932 113.785 106.553 1.00 159.95 ? 1   NAG B O3  1 
HETATM 3636 O O4  . NAG B 2 .   ? 139.143 113.051 104.880 1.00 203.88 ? 1   NAG B O4  1 
HETATM 3637 O O5  . NAG B 2 .   ? 136.397 113.435 102.458 1.00 127.05 ? 1   NAG B O5  1 
HETATM 3638 O O6  . NAG B 2 .   ? 138.000 111.056 102.221 1.00 186.47 ? 1   NAG B O6  1 
HETATM 3639 O O7  . NAG B 2 .   ? 133.227 114.072 106.193 1.00 124.55 ? 1   NAG B O7  1 
HETATM 3640 C C1  . NAG B 2 .   ? 139.633 111.979 105.634 1.00 226.86 ? 2   NAG B C1  1 
HETATM 3641 C C2  . NAG B 2 .   ? 141.162 112.009 105.696 1.00 229.67 ? 2   NAG B C2  1 
HETATM 3642 C C3  . NAG B 2 .   ? 141.687 110.892 106.602 1.00 243.98 ? 2   NAG B C3  1 
HETATM 3643 C C4  . NAG B 2 .   ? 141.030 110.956 107.977 1.00 259.68 ? 2   NAG B C4  1 
HETATM 3644 C C5  . NAG B 2 .   ? 139.509 110.955 107.824 1.00 261.62 ? 2   NAG B C5  1 
HETATM 3645 C C6  . NAG B 2 .   ? 138.776 111.123 109.145 1.00 266.91 ? 2   NAG B C6  1 
HETATM 3646 C C7  . NAG B 2 .   ? 142.206 112.999 103.695 1.00 221.87 ? 2   NAG B C7  1 
HETATM 3647 C C8  . NAG B 2 .   ? 142.757 112.722 102.329 1.00 231.52 ? 2   NAG B C8  1 
HETATM 3648 N N2  . NAG B 2 .   ? 141.790 111.933 104.390 1.00 225.42 ? 2   NAG B N2  1 
HETATM 3649 O O3  . NAG B 2 .   ? 143.105 110.951 106.729 1.00 244.86 ? 2   NAG B O3  1 
HETATM 3650 O O4  . NAG B 2 .   ? 141.447 109.825 108.741 1.00 260.67 ? 2   NAG B O4  1 
HETATM 3651 O O5  . NAG B 2 .   ? 139.097 112.039 106.959 1.00 247.16 ? 2   NAG B O5  1 
HETATM 3652 O O6  . NAG B 2 .   ? 138.985 112.413 109.733 1.00 267.97 ? 2   NAG B O6  1 
HETATM 3653 O O7  . NAG B 2 .   ? 142.141 114.138 104.146 1.00 211.16 ? 2   NAG B O7  1 
# 
