data_8ZXM
# 
_entry.id   8ZXM 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZXM         pdb_00008zxm 10.2210/pdb8zxm/pdb 
WWPDB D_1300048615 ?            ?                   
EMDB  EMD-60544    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-16 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZXM 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-14 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of human GLUT9 bound to urate' 
_pdbx_database_related.db_id          EMD-60544 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 4 
_pdbx_contact_author.email              t-2438@yokohama-cu.ac.jp 
_pdbx_contact_author.name_first         Tomohiro 
_pdbx_contact_author.name_last          Nishizawa 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7463-8398 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Matsushita, D.' 1 0009-0008-2024-2767 
'Lee, Y.'        2 0000-0002-1507-805X 
'Nishizawa, T.'  3 0000-0001-7463-8398 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Cell Rep' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2211-1247 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            44 
_citation.language                  ? 
_citation.page_first                115514 
_citation.page_last                 115514 
_citation.title                     'Structural basis of urate transport by glucose transporter 9.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.celrep.2025.115514 
_citation.pdbx_database_id_PubMed   40186864 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Matsushita, D.' 1 ? 
primary 'Toyoda, Y.'     2 ? 
primary 'Lee, Y.'        3 ? 
primary 'Aoi, M.'        4 ? 
primary 'Matsuo, H.'     5 ? 
primary 'Takada, T.'     6 ? 
primary 'Nishizawa, T.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Solute carrier family 2, facilitated glucose transporter member 9'                       59707.477 1 ? ? ? ? 
2 branched    man '2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose' 424.401   1 ? ? ? ? 
3 non-polymer syn 'URIC ACID'                                                                               168.110   1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Glucose transporter type 9,GLUT-9,Urate transporter' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNA
PTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQ
AGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVV
PAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTV
IVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTI
TLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYC
FLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRPGTENLYFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNA
PTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQ
AGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVV
PAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTV
IVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTI
TLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYC
FLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRPGTENLYFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        'URIC ACID' 
_pdbx_entity_nonpoly.comp_id     URC 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   ARG n 
1 4   LYS n 
1 5   GLN n 
1 6   ASN n 
1 7   ARG n 
1 8   ASN n 
1 9   SER n 
1 10  LYS n 
1 11  GLU n 
1 12  LEU n 
1 13  GLY n 
1 14  LEU n 
1 15  VAL n 
1 16  PRO n 
1 17  LEU n 
1 18  THR n 
1 19  ASP n 
1 20  ASP n 
1 21  THR n 
1 22  SER n 
1 23  HIS n 
1 24  ALA n 
1 25  GLY n 
1 26  PRO n 
1 27  PRO n 
1 28  GLY n 
1 29  PRO n 
1 30  GLY n 
1 31  ARG n 
1 32  ALA n 
1 33  LEU n 
1 34  LEU n 
1 35  GLU n 
1 36  CYS n 
1 37  ASP n 
1 38  HIS n 
1 39  LEU n 
1 40  ARG n 
1 41  SER n 
1 42  GLY n 
1 43  VAL n 
1 44  PRO n 
1 45  GLY n 
1 46  GLY n 
1 47  ARG n 
1 48  ARG n 
1 49  ARG n 
1 50  LYS n 
1 51  ASP n 
1 52  TRP n 
1 53  SER n 
1 54  CYS n 
1 55  SER n 
1 56  LEU n 
1 57  LEU n 
1 58  VAL n 
1 59  ALA n 
1 60  SER n 
1 61  LEU n 
1 62  ALA n 
1 63  GLY n 
1 64  ALA n 
1 65  PHE n 
1 66  GLY n 
1 67  SER n 
1 68  SER n 
1 69  PHE n 
1 70  LEU n 
1 71  TYR n 
1 72  GLY n 
1 73  TYR n 
1 74  ASN n 
1 75  LEU n 
1 76  SER n 
1 77  VAL n 
1 78  VAL n 
1 79  ASN n 
1 80  ALA n 
1 81  PRO n 
1 82  THR n 
1 83  PRO n 
1 84  TYR n 
1 85  ILE n 
1 86  LYS n 
1 87  ALA n 
1 88  PHE n 
1 89  TYR n 
1 90  ASN n 
1 91  GLU n 
1 92  SER n 
1 93  TRP n 
1 94  GLU n 
1 95  ARG n 
1 96  ARG n 
1 97  HIS n 
1 98  GLY n 
1 99  ARG n 
1 100 PRO n 
1 101 ILE n 
1 102 ASP n 
1 103 PRO n 
1 104 ASP n 
1 105 THR n 
1 106 LEU n 
1 107 THR n 
1 108 LEU n 
1 109 LEU n 
1 110 TRP n 
1 111 SER n 
1 112 VAL n 
1 113 THR n 
1 114 VAL n 
1 115 SER n 
1 116 ILE n 
1 117 PHE n 
1 118 ALA n 
1 119 ILE n 
1 120 GLY n 
1 121 GLY n 
1 122 LEU n 
1 123 VAL n 
1 124 GLY n 
1 125 THR n 
1 126 LEU n 
1 127 ILE n 
1 128 VAL n 
1 129 LYS n 
1 130 MET n 
1 131 ILE n 
1 132 GLY n 
1 133 LYS n 
1 134 VAL n 
1 135 LEU n 
1 136 GLY n 
1 137 ARG n 
1 138 LYS n 
1 139 HIS n 
1 140 THR n 
1 141 LEU n 
1 142 LEU n 
1 143 ALA n 
1 144 ASN n 
1 145 ASN n 
1 146 GLY n 
1 147 PHE n 
1 148 ALA n 
1 149 ILE n 
1 150 SER n 
1 151 ALA n 
1 152 ALA n 
1 153 LEU n 
1 154 LEU n 
1 155 MET n 
1 156 ALA n 
1 157 CYS n 
1 158 SER n 
1 159 LEU n 
1 160 GLN n 
1 161 ALA n 
1 162 GLY n 
1 163 ALA n 
1 164 PHE n 
1 165 GLU n 
1 166 MET n 
1 167 LEU n 
1 168 ILE n 
1 169 VAL n 
1 170 GLY n 
1 171 ARG n 
1 172 PHE n 
1 173 ILE n 
1 174 MET n 
1 175 GLY n 
1 176 ILE n 
1 177 ASP n 
1 178 GLY n 
1 179 GLY n 
1 180 VAL n 
1 181 ALA n 
1 182 LEU n 
1 183 SER n 
1 184 VAL n 
1 185 LEU n 
1 186 PRO n 
1 187 MET n 
1 188 TYR n 
1 189 LEU n 
1 190 SER n 
1 191 GLU n 
1 192 ILE n 
1 193 SER n 
1 194 PRO n 
1 195 LYS n 
1 196 GLU n 
1 197 ILE n 
1 198 ARG n 
1 199 GLY n 
1 200 SER n 
1 201 LEU n 
1 202 GLY n 
1 203 GLN n 
1 204 VAL n 
1 205 THR n 
1 206 ALA n 
1 207 ILE n 
1 208 PHE n 
1 209 ILE n 
1 210 CYS n 
1 211 ILE n 
1 212 GLY n 
1 213 VAL n 
1 214 PHE n 
1 215 THR n 
1 216 GLY n 
1 217 GLN n 
1 218 LEU n 
1 219 LEU n 
1 220 GLY n 
1 221 LEU n 
1 222 PRO n 
1 223 GLU n 
1 224 LEU n 
1 225 LEU n 
1 226 GLY n 
1 227 LYS n 
1 228 GLU n 
1 229 SER n 
1 230 THR n 
1 231 TRP n 
1 232 PRO n 
1 233 TYR n 
1 234 LEU n 
1 235 PHE n 
1 236 GLY n 
1 237 VAL n 
1 238 ILE n 
1 239 VAL n 
1 240 VAL n 
1 241 PRO n 
1 242 ALA n 
1 243 VAL n 
1 244 VAL n 
1 245 GLN n 
1 246 LEU n 
1 247 LEU n 
1 248 SER n 
1 249 LEU n 
1 250 PRO n 
1 251 PHE n 
1 252 LEU n 
1 253 PRO n 
1 254 ASP n 
1 255 SER n 
1 256 PRO n 
1 257 ARG n 
1 258 TYR n 
1 259 LEU n 
1 260 LEU n 
1 261 LEU n 
1 262 GLU n 
1 263 LYS n 
1 264 HIS n 
1 265 ASN n 
1 266 GLU n 
1 267 ALA n 
1 268 ARG n 
1 269 ALA n 
1 270 VAL n 
1 271 LYS n 
1 272 ALA n 
1 273 PHE n 
1 274 GLN n 
1 275 THR n 
1 276 PHE n 
1 277 LEU n 
1 278 GLY n 
1 279 LYS n 
1 280 ALA n 
1 281 ASP n 
1 282 VAL n 
1 283 SER n 
1 284 GLN n 
1 285 GLU n 
1 286 VAL n 
1 287 GLU n 
1 288 GLU n 
1 289 VAL n 
1 290 LEU n 
1 291 ALA n 
1 292 GLU n 
1 293 SER n 
1 294 ARG n 
1 295 VAL n 
1 296 GLN n 
1 297 ARG n 
1 298 SER n 
1 299 ILE n 
1 300 ARG n 
1 301 LEU n 
1 302 VAL n 
1 303 SER n 
1 304 VAL n 
1 305 LEU n 
1 306 GLU n 
1 307 LEU n 
1 308 LEU n 
1 309 ARG n 
1 310 ALA n 
1 311 PRO n 
1 312 TYR n 
1 313 VAL n 
1 314 ARG n 
1 315 TRP n 
1 316 GLN n 
1 317 VAL n 
1 318 VAL n 
1 319 THR n 
1 320 VAL n 
1 321 ILE n 
1 322 VAL n 
1 323 THR n 
1 324 MET n 
1 325 ALA n 
1 326 CYS n 
1 327 TYR n 
1 328 GLN n 
1 329 LEU n 
1 330 CYS n 
1 331 GLY n 
1 332 LEU n 
1 333 ASN n 
1 334 ALA n 
1 335 ILE n 
1 336 TRP n 
1 337 PHE n 
1 338 TYR n 
1 339 THR n 
1 340 ASN n 
1 341 SER n 
1 342 ILE n 
1 343 PHE n 
1 344 GLY n 
1 345 LYS n 
1 346 ALA n 
1 347 GLY n 
1 348 ILE n 
1 349 PRO n 
1 350 PRO n 
1 351 ALA n 
1 352 LYS n 
1 353 ILE n 
1 354 PRO n 
1 355 TYR n 
1 356 VAL n 
1 357 THR n 
1 358 LEU n 
1 359 SER n 
1 360 THR n 
1 361 GLY n 
1 362 GLY n 
1 363 ILE n 
1 364 GLU n 
1 365 THR n 
1 366 LEU n 
1 367 ALA n 
1 368 ALA n 
1 369 VAL n 
1 370 PHE n 
1 371 SER n 
1 372 GLY n 
1 373 LEU n 
1 374 VAL n 
1 375 ILE n 
1 376 GLU n 
1 377 HIS n 
1 378 LEU n 
1 379 GLY n 
1 380 ARG n 
1 381 ARG n 
1 382 PRO n 
1 383 LEU n 
1 384 LEU n 
1 385 ILE n 
1 386 GLY n 
1 387 GLY n 
1 388 PHE n 
1 389 GLY n 
1 390 LEU n 
1 391 MET n 
1 392 GLY n 
1 393 LEU n 
1 394 PHE n 
1 395 PHE n 
1 396 GLY n 
1 397 THR n 
1 398 LEU n 
1 399 THR n 
1 400 ILE n 
1 401 THR n 
1 402 LEU n 
1 403 THR n 
1 404 LEU n 
1 405 GLN n 
1 406 ASP n 
1 407 HIS n 
1 408 ALA n 
1 409 PRO n 
1 410 TRP n 
1 411 VAL n 
1 412 PRO n 
1 413 TYR n 
1 414 LEU n 
1 415 SER n 
1 416 ILE n 
1 417 VAL n 
1 418 GLY n 
1 419 ILE n 
1 420 LEU n 
1 421 ALA n 
1 422 ILE n 
1 423 ILE n 
1 424 ALA n 
1 425 SER n 
1 426 PHE n 
1 427 CYS n 
1 428 SER n 
1 429 GLY n 
1 430 PRO n 
1 431 GLY n 
1 432 GLY n 
1 433 ILE n 
1 434 PRO n 
1 435 PHE n 
1 436 ILE n 
1 437 LEU n 
1 438 THR n 
1 439 GLY n 
1 440 GLU n 
1 441 PHE n 
1 442 PHE n 
1 443 GLN n 
1 444 GLN n 
1 445 SER n 
1 446 GLN n 
1 447 ARG n 
1 448 PRO n 
1 449 ALA n 
1 450 ALA n 
1 451 PHE n 
1 452 ILE n 
1 453 ILE n 
1 454 ALA n 
1 455 GLY n 
1 456 THR n 
1 457 VAL n 
1 458 ASN n 
1 459 TRP n 
1 460 LEU n 
1 461 SER n 
1 462 ASN n 
1 463 PHE n 
1 464 ALA n 
1 465 VAL n 
1 466 GLY n 
1 467 LEU n 
1 468 LEU n 
1 469 PHE n 
1 470 PRO n 
1 471 PHE n 
1 472 ILE n 
1 473 GLN n 
1 474 LYS n 
1 475 SER n 
1 476 LEU n 
1 477 ASP n 
1 478 THR n 
1 479 TYR n 
1 480 CYS n 
1 481 PHE n 
1 482 LEU n 
1 483 VAL n 
1 484 PHE n 
1 485 ALA n 
1 486 THR n 
1 487 ILE n 
1 488 CYS n 
1 489 ILE n 
1 490 THR n 
1 491 GLY n 
1 492 ALA n 
1 493 ILE n 
1 494 TYR n 
1 495 LEU n 
1 496 TYR n 
1 497 PHE n 
1 498 VAL n 
1 499 LEU n 
1 500 PRO n 
1 501 GLU n 
1 502 THR n 
1 503 LYS n 
1 504 ASN n 
1 505 ARG n 
1 506 THR n 
1 507 TYR n 
1 508 ALA n 
1 509 GLU n 
1 510 ILE n 
1 511 SER n 
1 512 GLN n 
1 513 ALA n 
1 514 PHE n 
1 515 SER n 
1 516 LYS n 
1 517 ARG n 
1 518 ASN n 
1 519 LYS n 
1 520 ALA n 
1 521 TYR n 
1 522 PRO n 
1 523 PRO n 
1 524 GLU n 
1 525 GLU n 
1 526 LYS n 
1 527 ILE n 
1 528 ASP n 
1 529 SER n 
1 530 ALA n 
1 531 VAL n 
1 532 THR n 
1 533 ASP n 
1 534 GLY n 
1 535 LYS n 
1 536 ILE n 
1 537 ASN n 
1 538 GLY n 
1 539 ARG n 
1 540 PRO n 
1 541 GLY n 
1 542 THR n 
1 543 GLU n 
1 544 ASN n 
1 545 LEU n 
1 546 TYR n 
1 547 PHE n 
1 548 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   548 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SLC2A9, GLUT9' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            HEK293F 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_branch.entity_id   2 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 2 DGlcpNAcb1-4DGlcpNAcb1-ROH                            'Glycam Condensed Sequence' GMML       1.0   
2 2 'WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1' WURCS                       PDB2Glycan 1.1.0 
3 2 '[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}'       LINUCS                      PDB-CARE   ?     
# 
_pdbx_entity_branch_link.link_id                    1 
_pdbx_entity_branch_link.entity_id                  2 
_pdbx_entity_branch_link.entity_branch_list_num_1   2 
_pdbx_entity_branch_link.comp_id_1                  NAG 
_pdbx_entity_branch_link.atom_id_1                  C1 
_pdbx_entity_branch_link.leaving_atom_id_1          O1 
_pdbx_entity_branch_link.entity_branch_list_num_2   1 
_pdbx_entity_branch_link.comp_id_2                  NAG 
_pdbx_entity_branch_link.atom_id_2                  O4 
_pdbx_entity_branch_link.leaving_atom_id_2          HO4 
_pdbx_entity_branch_link.value_order                sing 
_pdbx_entity_branch_link.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
URC non-polymer                  . 'URIC ACID'                              '7,9-DIHYDRO-1H-PURINE-2,6,8(3H)-TRIONE' 'C5 H4 N4 O3' 
168.110 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   ARG 3   3   ?   ?   ?   A . n 
A 1 4   LYS 4   4   ?   ?   ?   A . n 
A 1 5   GLN 5   5   ?   ?   ?   A . n 
A 1 6   ASN 6   6   ?   ?   ?   A . n 
A 1 7   ARG 7   7   ?   ?   ?   A . n 
A 1 8   ASN 8   8   ?   ?   ?   A . n 
A 1 9   SER 9   9   ?   ?   ?   A . n 
A 1 10  LYS 10  10  ?   ?   ?   A . n 
A 1 11  GLU 11  11  ?   ?   ?   A . n 
A 1 12  LEU 12  12  ?   ?   ?   A . n 
A 1 13  GLY 13  13  ?   ?   ?   A . n 
A 1 14  LEU 14  14  ?   ?   ?   A . n 
A 1 15  VAL 15  15  ?   ?   ?   A . n 
A 1 16  PRO 16  16  ?   ?   ?   A . n 
A 1 17  LEU 17  17  ?   ?   ?   A . n 
A 1 18  THR 18  18  ?   ?   ?   A . n 
A 1 19  ASP 19  19  ?   ?   ?   A . n 
A 1 20  ASP 20  20  ?   ?   ?   A . n 
A 1 21  THR 21  21  ?   ?   ?   A . n 
A 1 22  SER 22  22  ?   ?   ?   A . n 
A 1 23  HIS 23  23  ?   ?   ?   A . n 
A 1 24  ALA 24  24  ?   ?   ?   A . n 
A 1 25  GLY 25  25  ?   ?   ?   A . n 
A 1 26  PRO 26  26  ?   ?   ?   A . n 
A 1 27  PRO 27  27  ?   ?   ?   A . n 
A 1 28  GLY 28  28  ?   ?   ?   A . n 
A 1 29  PRO 29  29  ?   ?   ?   A . n 
A 1 30  GLY 30  30  ?   ?   ?   A . n 
A 1 31  ARG 31  31  ?   ?   ?   A . n 
A 1 32  ALA 32  32  ?   ?   ?   A . n 
A 1 33  LEU 33  33  ?   ?   ?   A . n 
A 1 34  LEU 34  34  ?   ?   ?   A . n 
A 1 35  GLU 35  35  ?   ?   ?   A . n 
A 1 36  CYS 36  36  ?   ?   ?   A . n 
A 1 37  ASP 37  37  ?   ?   ?   A . n 
A 1 38  HIS 38  38  ?   ?   ?   A . n 
A 1 39  LEU 39  39  ?   ?   ?   A . n 
A 1 40  ARG 40  40  ?   ?   ?   A . n 
A 1 41  SER 41  41  ?   ?   ?   A . n 
A 1 42  GLY 42  42  ?   ?   ?   A . n 
A 1 43  VAL 43  43  ?   ?   ?   A . n 
A 1 44  PRO 44  44  ?   ?   ?   A . n 
A 1 45  GLY 45  45  ?   ?   ?   A . n 
A 1 46  GLY 46  46  ?   ?   ?   A . n 
A 1 47  ARG 47  47  ?   ?   ?   A . n 
A 1 48  ARG 48  48  ?   ?   ?   A . n 
A 1 49  ARG 49  49  ?   ?   ?   A . n 
A 1 50  LYS 50  50  ?   ?   ?   A . n 
A 1 51  ASP 51  51  ?   ?   ?   A . n 
A 1 52  TRP 52  52  52  TRP TRP A . n 
A 1 53  SER 53  53  53  SER SER A . n 
A 1 54  CYS 54  54  54  CYS CYS A . n 
A 1 55  SER 55  55  55  SER SER A . n 
A 1 56  LEU 56  56  56  LEU LEU A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  VAL 58  58  58  VAL VAL A . n 
A 1 59  ALA 59  59  59  ALA ALA A . n 
A 1 60  SER 60  60  60  SER SER A . n 
A 1 61  LEU 61  61  61  LEU LEU A . n 
A 1 62  ALA 62  62  62  ALA ALA A . n 
A 1 63  GLY 63  63  63  GLY GLY A . n 
A 1 64  ALA 64  64  64  ALA ALA A . n 
A 1 65  PHE 65  65  65  PHE PHE A . n 
A 1 66  GLY 66  66  66  GLY GLY A . n 
A 1 67  SER 67  67  67  SER SER A . n 
A 1 68  SER 68  68  68  SER SER A . n 
A 1 69  PHE 69  69  69  PHE PHE A . n 
A 1 70  LEU 70  70  70  LEU LEU A . n 
A 1 71  TYR 71  71  71  TYR TYR A . n 
A 1 72  GLY 72  72  72  GLY GLY A . n 
A 1 73  TYR 73  73  73  TYR TYR A . n 
A 1 74  ASN 74  74  74  ASN ASN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  SER 76  76  76  SER SER A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  VAL 78  78  78  VAL VAL A . n 
A 1 79  ASN 79  79  79  ASN ASN A . n 
A 1 80  ALA 80  80  80  ALA ALA A . n 
A 1 81  PRO 81  81  81  PRO PRO A . n 
A 1 82  THR 82  82  82  THR THR A . n 
A 1 83  PRO 83  83  83  PRO PRO A . n 
A 1 84  TYR 84  84  84  TYR TYR A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  LYS 86  86  86  LYS LYS A . n 
A 1 87  ALA 87  87  87  ALA ALA A . n 
A 1 88  PHE 88  88  88  PHE PHE A . n 
A 1 89  TYR 89  89  89  TYR TYR A . n 
A 1 90  ASN 90  90  90  ASN ASN A . n 
A 1 91  GLU 91  91  91  GLU GLU A . n 
A 1 92  SER 92  92  92  SER SER A . n 
A 1 93  TRP 93  93  93  TRP TRP A . n 
A 1 94  GLU 94  94  94  GLU GLU A . n 
A 1 95  ARG 95  95  95  ARG ARG A . n 
A 1 96  ARG 96  96  96  ARG ARG A . n 
A 1 97  HIS 97  97  97  HIS HIS A . n 
A 1 98  GLY 98  98  98  GLY GLY A . n 
A 1 99  ARG 99  99  99  ARG ARG A . n 
A 1 100 PRO 100 100 100 PRO PRO A . n 
A 1 101 ILE 101 101 101 ILE ILE A . n 
A 1 102 ASP 102 102 102 ASP ASP A . n 
A 1 103 PRO 103 103 103 PRO PRO A . n 
A 1 104 ASP 104 104 104 ASP ASP A . n 
A 1 105 THR 105 105 105 THR THR A . n 
A 1 106 LEU 106 106 106 LEU LEU A . n 
A 1 107 THR 107 107 107 THR THR A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 TRP 110 110 110 TRP TRP A . n 
A 1 111 SER 111 111 111 SER SER A . n 
A 1 112 VAL 112 112 112 VAL VAL A . n 
A 1 113 THR 113 113 113 THR THR A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 SER 115 115 115 SER SER A . n 
A 1 116 ILE 116 116 116 ILE ILE A . n 
A 1 117 PHE 117 117 117 PHE PHE A . n 
A 1 118 ALA 118 118 118 ALA ALA A . n 
A 1 119 ILE 119 119 119 ILE ILE A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 GLY 121 121 121 GLY GLY A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 VAL 123 123 123 VAL VAL A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 THR 125 125 125 THR THR A . n 
A 1 126 LEU 126 126 126 LEU LEU A . n 
A 1 127 ILE 127 127 127 ILE ILE A . n 
A 1 128 VAL 128 128 128 VAL VAL A . n 
A 1 129 LYS 129 129 129 LYS LYS A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ILE 131 131 131 ILE ILE A . n 
A 1 132 GLY 132 132 132 GLY GLY A . n 
A 1 133 LYS 133 133 133 LYS LYS A . n 
A 1 134 VAL 134 134 134 VAL VAL A . n 
A 1 135 LEU 135 135 135 LEU LEU A . n 
A 1 136 GLY 136 136 136 GLY GLY A . n 
A 1 137 ARG 137 137 137 ARG ARG A . n 
A 1 138 LYS 138 138 138 LYS LYS A . n 
A 1 139 HIS 139 139 139 HIS HIS A . n 
A 1 140 THR 140 140 140 THR THR A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 LEU 142 142 142 LEU LEU A . n 
A 1 143 ALA 143 143 143 ALA ALA A . n 
A 1 144 ASN 144 144 144 ASN ASN A . n 
A 1 145 ASN 145 145 145 ASN ASN A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 PHE 147 147 147 PHE PHE A . n 
A 1 148 ALA 148 148 148 ALA ALA A . n 
A 1 149 ILE 149 149 149 ILE ILE A . n 
A 1 150 SER 150 150 150 SER SER A . n 
A 1 151 ALA 151 151 151 ALA ALA A . n 
A 1 152 ALA 152 152 152 ALA ALA A . n 
A 1 153 LEU 153 153 153 LEU LEU A . n 
A 1 154 LEU 154 154 154 LEU LEU A . n 
A 1 155 MET 155 155 155 MET MET A . n 
A 1 156 ALA 156 156 156 ALA ALA A . n 
A 1 157 CYS 157 157 157 CYS CYS A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 LEU 159 159 159 LEU LEU A . n 
A 1 160 GLN 160 160 160 GLN GLN A . n 
A 1 161 ALA 161 161 161 ALA ALA A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 ALA 163 163 163 ALA ALA A . n 
A 1 164 PHE 164 164 164 PHE PHE A . n 
A 1 165 GLU 165 165 165 GLU GLU A . n 
A 1 166 MET 166 166 166 MET MET A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 ILE 168 168 168 ILE ILE A . n 
A 1 169 VAL 169 169 169 VAL VAL A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 ARG 171 171 171 ARG ARG A . n 
A 1 172 PHE 172 172 172 PHE PHE A . n 
A 1 173 ILE 173 173 173 ILE ILE A . n 
A 1 174 MET 174 174 174 MET MET A . n 
A 1 175 GLY 175 175 175 GLY GLY A . n 
A 1 176 ILE 176 176 176 ILE ILE A . n 
A 1 177 ASP 177 177 177 ASP ASP A . n 
A 1 178 GLY 178 178 178 GLY GLY A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 VAL 180 180 180 VAL VAL A . n 
A 1 181 ALA 181 181 181 ALA ALA A . n 
A 1 182 LEU 182 182 182 LEU LEU A . n 
A 1 183 SER 183 183 183 SER SER A . n 
A 1 184 VAL 184 184 184 VAL VAL A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 PRO 186 186 186 PRO PRO A . n 
A 1 187 MET 187 187 187 MET MET A . n 
A 1 188 TYR 188 188 188 TYR TYR A . n 
A 1 189 LEU 189 189 189 LEU LEU A . n 
A 1 190 SER 190 190 190 SER SER A . n 
A 1 191 GLU 191 191 191 GLU GLU A . n 
A 1 192 ILE 192 192 192 ILE ILE A . n 
A 1 193 SER 193 193 193 SER SER A . n 
A 1 194 PRO 194 194 194 PRO PRO A . n 
A 1 195 LYS 195 195 195 LYS LYS A . n 
A 1 196 GLU 196 196 196 GLU GLU A . n 
A 1 197 ILE 197 197 197 ILE ILE A . n 
A 1 198 ARG 198 198 198 ARG ARG A . n 
A 1 199 GLY 199 199 199 GLY GLY A . n 
A 1 200 SER 200 200 200 SER SER A . n 
A 1 201 LEU 201 201 201 LEU LEU A . n 
A 1 202 GLY 202 202 202 GLY GLY A . n 
A 1 203 GLN 203 203 203 GLN GLN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 THR 205 205 205 THR THR A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 ILE 207 207 207 ILE ILE A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 ILE 209 209 209 ILE ILE A . n 
A 1 210 CYS 210 210 210 CYS CYS A . n 
A 1 211 ILE 211 211 211 ILE ILE A . n 
A 1 212 GLY 212 212 212 GLY GLY A . n 
A 1 213 VAL 213 213 213 VAL VAL A . n 
A 1 214 PHE 214 214 214 PHE PHE A . n 
A 1 215 THR 215 215 215 THR THR A . n 
A 1 216 GLY 216 216 216 GLY GLY A . n 
A 1 217 GLN 217 217 217 GLN GLN A . n 
A 1 218 LEU 218 218 218 LEU LEU A . n 
A 1 219 LEU 219 219 219 LEU LEU A . n 
A 1 220 GLY 220 220 220 GLY GLY A . n 
A 1 221 LEU 221 221 221 LEU LEU A . n 
A 1 222 PRO 222 222 222 PRO PRO A . n 
A 1 223 GLU 223 223 223 GLU GLU A . n 
A 1 224 LEU 224 224 224 LEU LEU A . n 
A 1 225 LEU 225 225 225 LEU LEU A . n 
A 1 226 GLY 226 226 226 GLY GLY A . n 
A 1 227 LYS 227 227 227 LYS LYS A . n 
A 1 228 GLU 228 228 228 GLU GLU A . n 
A 1 229 SER 229 229 229 SER SER A . n 
A 1 230 THR 230 230 230 THR THR A . n 
A 1 231 TRP 231 231 231 TRP TRP A . n 
A 1 232 PRO 232 232 232 PRO PRO A . n 
A 1 233 TYR 233 233 233 TYR TYR A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 PHE 235 235 235 PHE PHE A . n 
A 1 236 GLY 236 236 236 GLY GLY A . n 
A 1 237 VAL 237 237 237 VAL VAL A . n 
A 1 238 ILE 238 238 238 ILE ILE A . n 
A 1 239 VAL 239 239 239 VAL VAL A . n 
A 1 240 VAL 240 240 240 VAL VAL A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 ALA 242 242 242 ALA ALA A . n 
A 1 243 VAL 243 243 243 VAL VAL A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 GLN 245 245 245 GLN GLN A . n 
A 1 246 LEU 246 246 246 LEU LEU A . n 
A 1 247 LEU 247 247 247 LEU LEU A . n 
A 1 248 SER 248 248 248 SER SER A . n 
A 1 249 LEU 249 249 249 LEU LEU A . n 
A 1 250 PRO 250 250 250 PRO PRO A . n 
A 1 251 PHE 251 251 251 PHE PHE A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 PRO 253 253 253 PRO PRO A . n 
A 1 254 ASP 254 254 254 ASP ASP A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 PRO 256 256 256 PRO PRO A . n 
A 1 257 ARG 257 257 257 ARG ARG A . n 
A 1 258 TYR 258 258 258 TYR TYR A . n 
A 1 259 LEU 259 259 259 LEU LEU A . n 
A 1 260 LEU 260 260 260 LEU LEU A . n 
A 1 261 LEU 261 261 261 LEU LEU A . n 
A 1 262 GLU 262 262 262 GLU GLU A . n 
A 1 263 LYS 263 263 263 LYS LYS A . n 
A 1 264 HIS 264 264 264 HIS HIS A . n 
A 1 265 ASN 265 265 265 ASN ASN A . n 
A 1 266 GLU 266 266 266 GLU GLU A . n 
A 1 267 ALA 267 267 267 ALA ALA A . n 
A 1 268 ARG 268 268 268 ARG ARG A . n 
A 1 269 ALA 269 269 269 ALA ALA A . n 
A 1 270 VAL 270 270 270 VAL VAL A . n 
A 1 271 LYS 271 271 271 LYS LYS A . n 
A 1 272 ALA 272 272 272 ALA ALA A . n 
A 1 273 PHE 273 273 273 PHE PHE A . n 
A 1 274 GLN 274 274 274 GLN GLN A . n 
A 1 275 THR 275 275 275 THR THR A . n 
A 1 276 PHE 276 276 276 PHE PHE A . n 
A 1 277 LEU 277 277 277 LEU LEU A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 LYS 279 279 279 LYS LYS A . n 
A 1 280 ALA 280 280 280 ALA ALA A . n 
A 1 281 ASP 281 281 281 ASP ASP A . n 
A 1 282 VAL 282 282 282 VAL VAL A . n 
A 1 283 SER 283 283 283 SER SER A . n 
A 1 284 GLN 284 284 284 GLN GLN A . n 
A 1 285 GLU 285 285 285 GLU GLU A . n 
A 1 286 VAL 286 286 286 VAL VAL A . n 
A 1 287 GLU 287 287 287 GLU GLU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 VAL 289 289 289 VAL VAL A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 ALA 291 291 291 ALA ALA A . n 
A 1 292 GLU 292 292 292 GLU GLU A . n 
A 1 293 SER 293 293 293 SER SER A . n 
A 1 294 ARG 294 294 294 ARG ARG A . n 
A 1 295 VAL 295 295 295 VAL VAL A . n 
A 1 296 GLN 296 296 296 GLN GLN A . n 
A 1 297 ARG 297 297 297 ARG ARG A . n 
A 1 298 SER 298 298 298 SER SER A . n 
A 1 299 ILE 299 299 299 ILE ILE A . n 
A 1 300 ARG 300 300 300 ARG ARG A . n 
A 1 301 LEU 301 301 301 LEU LEU A . n 
A 1 302 VAL 302 302 302 VAL VAL A . n 
A 1 303 SER 303 303 303 SER SER A . n 
A 1 304 VAL 304 304 304 VAL VAL A . n 
A 1 305 LEU 305 305 305 LEU LEU A . n 
A 1 306 GLU 306 306 306 GLU GLU A . n 
A 1 307 LEU 307 307 307 LEU LEU A . n 
A 1 308 LEU 308 308 308 LEU LEU A . n 
A 1 309 ARG 309 309 309 ARG ARG A . n 
A 1 310 ALA 310 310 310 ALA ALA A . n 
A 1 311 PRO 311 311 311 PRO PRO A . n 
A 1 312 TYR 312 312 312 TYR TYR A . n 
A 1 313 VAL 313 313 313 VAL VAL A . n 
A 1 314 ARG 314 314 314 ARG ARG A . n 
A 1 315 TRP 315 315 315 TRP TRP A . n 
A 1 316 GLN 316 316 316 GLN GLN A . n 
A 1 317 VAL 317 317 317 VAL VAL A . n 
A 1 318 VAL 318 318 318 VAL VAL A . n 
A 1 319 THR 319 319 319 THR THR A . n 
A 1 320 VAL 320 320 320 VAL VAL A . n 
A 1 321 ILE 321 321 321 ILE ILE A . n 
A 1 322 VAL 322 322 322 VAL VAL A . n 
A 1 323 THR 323 323 323 THR THR A . n 
A 1 324 MET 324 324 324 MET MET A . n 
A 1 325 ALA 325 325 325 ALA ALA A . n 
A 1 326 CYS 326 326 326 CYS CYS A . n 
A 1 327 TYR 327 327 327 TYR TYR A . n 
A 1 328 GLN 328 328 328 GLN GLN A . n 
A 1 329 LEU 329 329 329 LEU LEU A . n 
A 1 330 CYS 330 330 330 CYS CYS A . n 
A 1 331 GLY 331 331 331 GLY GLY A . n 
A 1 332 LEU 332 332 332 LEU LEU A . n 
A 1 333 ASN 333 333 333 ASN ASN A . n 
A 1 334 ALA 334 334 334 ALA ALA A . n 
A 1 335 ILE 335 335 335 ILE ILE A . n 
A 1 336 TRP 336 336 336 TRP TRP A . n 
A 1 337 PHE 337 337 337 PHE PHE A . n 
A 1 338 TYR 338 338 338 TYR TYR A . n 
A 1 339 THR 339 339 339 THR THR A . n 
A 1 340 ASN 340 340 340 ASN ASN A . n 
A 1 341 SER 341 341 341 SER SER A . n 
A 1 342 ILE 342 342 342 ILE ILE A . n 
A 1 343 PHE 343 343 343 PHE PHE A . n 
A 1 344 GLY 344 344 344 GLY GLY A . n 
A 1 345 LYS 345 345 345 LYS LYS A . n 
A 1 346 ALA 346 346 346 ALA ALA A . n 
A 1 347 GLY 347 347 347 GLY GLY A . n 
A 1 348 ILE 348 348 348 ILE ILE A . n 
A 1 349 PRO 349 349 349 PRO PRO A . n 
A 1 350 PRO 350 350 350 PRO PRO A . n 
A 1 351 ALA 351 351 351 ALA ALA A . n 
A 1 352 LYS 352 352 352 LYS LYS A . n 
A 1 353 ILE 353 353 353 ILE ILE A . n 
A 1 354 PRO 354 354 354 PRO PRO A . n 
A 1 355 TYR 355 355 355 TYR TYR A . n 
A 1 356 VAL 356 356 356 VAL VAL A . n 
A 1 357 THR 357 357 357 THR THR A . n 
A 1 358 LEU 358 358 358 LEU LEU A . n 
A 1 359 SER 359 359 359 SER SER A . n 
A 1 360 THR 360 360 360 THR THR A . n 
A 1 361 GLY 361 361 361 GLY GLY A . n 
A 1 362 GLY 362 362 362 GLY GLY A . n 
A 1 363 ILE 363 363 363 ILE ILE A . n 
A 1 364 GLU 364 364 364 GLU GLU A . n 
A 1 365 THR 365 365 365 THR THR A . n 
A 1 366 LEU 366 366 366 LEU LEU A . n 
A 1 367 ALA 367 367 367 ALA ALA A . n 
A 1 368 ALA 368 368 368 ALA ALA A . n 
A 1 369 VAL 369 369 369 VAL VAL A . n 
A 1 370 PHE 370 370 370 PHE PHE A . n 
A 1 371 SER 371 371 371 SER SER A . n 
A 1 372 GLY 372 372 372 GLY GLY A . n 
A 1 373 LEU 373 373 373 LEU LEU A . n 
A 1 374 VAL 374 374 374 VAL VAL A . n 
A 1 375 ILE 375 375 375 ILE ILE A . n 
A 1 376 GLU 376 376 376 GLU GLU A . n 
A 1 377 HIS 377 377 377 HIS HIS A . n 
A 1 378 LEU 378 378 378 LEU LEU A . n 
A 1 379 GLY 379 379 379 GLY GLY A . n 
A 1 380 ARG 380 380 380 ARG ARG A . n 
A 1 381 ARG 381 381 381 ARG ARG A . n 
A 1 382 PRO 382 382 382 PRO PRO A . n 
A 1 383 LEU 383 383 383 LEU LEU A . n 
A 1 384 LEU 384 384 384 LEU LEU A . n 
A 1 385 ILE 385 385 385 ILE ILE A . n 
A 1 386 GLY 386 386 386 GLY GLY A . n 
A 1 387 GLY 387 387 387 GLY GLY A . n 
A 1 388 PHE 388 388 388 PHE PHE A . n 
A 1 389 GLY 389 389 389 GLY GLY A . n 
A 1 390 LEU 390 390 390 LEU LEU A . n 
A 1 391 MET 391 391 391 MET MET A . n 
A 1 392 GLY 392 392 392 GLY GLY A . n 
A 1 393 LEU 393 393 393 LEU LEU A . n 
A 1 394 PHE 394 394 394 PHE PHE A . n 
A 1 395 PHE 395 395 395 PHE PHE A . n 
A 1 396 GLY 396 396 396 GLY GLY A . n 
A 1 397 THR 397 397 397 THR THR A . n 
A 1 398 LEU 398 398 398 LEU LEU A . n 
A 1 399 THR 399 399 399 THR THR A . n 
A 1 400 ILE 400 400 400 ILE ILE A . n 
A 1 401 THR 401 401 401 THR THR A . n 
A 1 402 LEU 402 402 402 LEU LEU A . n 
A 1 403 THR 403 403 403 THR THR A . n 
A 1 404 LEU 404 404 404 LEU LEU A . n 
A 1 405 GLN 405 405 405 GLN GLN A . n 
A 1 406 ASP 406 406 406 ASP ASP A . n 
A 1 407 HIS 407 407 407 HIS HIS A . n 
A 1 408 ALA 408 408 408 ALA ALA A . n 
A 1 409 PRO 409 409 409 PRO PRO A . n 
A 1 410 TRP 410 410 410 TRP TRP A . n 
A 1 411 VAL 411 411 411 VAL VAL A . n 
A 1 412 PRO 412 412 412 PRO PRO A . n 
A 1 413 TYR 413 413 413 TYR TYR A . n 
A 1 414 LEU 414 414 414 LEU LEU A . n 
A 1 415 SER 415 415 415 SER SER A . n 
A 1 416 ILE 416 416 416 ILE ILE A . n 
A 1 417 VAL 417 417 417 VAL VAL A . n 
A 1 418 GLY 418 418 418 GLY GLY A . n 
A 1 419 ILE 419 419 419 ILE ILE A . n 
A 1 420 LEU 420 420 420 LEU LEU A . n 
A 1 421 ALA 421 421 421 ALA ALA A . n 
A 1 422 ILE 422 422 422 ILE ILE A . n 
A 1 423 ILE 423 423 423 ILE ILE A . n 
A 1 424 ALA 424 424 424 ALA ALA A . n 
A 1 425 SER 425 425 425 SER SER A . n 
A 1 426 PHE 426 426 426 PHE PHE A . n 
A 1 427 CYS 427 427 427 CYS CYS A . n 
A 1 428 SER 428 428 428 SER SER A . n 
A 1 429 GLY 429 429 429 GLY GLY A . n 
A 1 430 PRO 430 430 430 PRO PRO A . n 
A 1 431 GLY 431 431 431 GLY GLY A . n 
A 1 432 GLY 432 432 432 GLY GLY A . n 
A 1 433 ILE 433 433 433 ILE ILE A . n 
A 1 434 PRO 434 434 434 PRO PRO A . n 
A 1 435 PHE 435 435 435 PHE PHE A . n 
A 1 436 ILE 436 436 436 ILE ILE A . n 
A 1 437 LEU 437 437 437 LEU LEU A . n 
A 1 438 THR 438 438 438 THR THR A . n 
A 1 439 GLY 439 439 439 GLY GLY A . n 
A 1 440 GLU 440 440 440 GLU GLU A . n 
A 1 441 PHE 441 441 441 PHE PHE A . n 
A 1 442 PHE 442 442 442 PHE PHE A . n 
A 1 443 GLN 443 443 443 GLN GLN A . n 
A 1 444 GLN 444 444 444 GLN GLN A . n 
A 1 445 SER 445 445 445 SER SER A . n 
A 1 446 GLN 446 446 446 GLN GLN A . n 
A 1 447 ARG 447 447 447 ARG ARG A . n 
A 1 448 PRO 448 448 448 PRO PRO A . n 
A 1 449 ALA 449 449 449 ALA ALA A . n 
A 1 450 ALA 450 450 450 ALA ALA A . n 
A 1 451 PHE 451 451 451 PHE PHE A . n 
A 1 452 ILE 452 452 452 ILE ILE A . n 
A 1 453 ILE 453 453 453 ILE ILE A . n 
A 1 454 ALA 454 454 454 ALA ALA A . n 
A 1 455 GLY 455 455 455 GLY GLY A . n 
A 1 456 THR 456 456 456 THR THR A . n 
A 1 457 VAL 457 457 457 VAL VAL A . n 
A 1 458 ASN 458 458 458 ASN ASN A . n 
A 1 459 TRP 459 459 459 TRP TRP A . n 
A 1 460 LEU 460 460 460 LEU LEU A . n 
A 1 461 SER 461 461 461 SER SER A . n 
A 1 462 ASN 462 462 462 ASN ASN A . n 
A 1 463 PHE 463 463 463 PHE PHE A . n 
A 1 464 ALA 464 464 464 ALA ALA A . n 
A 1 465 VAL 465 465 465 VAL VAL A . n 
A 1 466 GLY 466 466 466 GLY GLY A . n 
A 1 467 LEU 467 467 467 LEU LEU A . n 
A 1 468 LEU 468 468 468 LEU LEU A . n 
A 1 469 PHE 469 469 469 PHE PHE A . n 
A 1 470 PRO 470 470 470 PRO PRO A . n 
A 1 471 PHE 471 471 471 PHE PHE A . n 
A 1 472 ILE 472 472 472 ILE ILE A . n 
A 1 473 GLN 473 473 473 GLN GLN A . n 
A 1 474 LYS 474 474 474 LYS LYS A . n 
A 1 475 SER 475 475 475 SER SER A . n 
A 1 476 LEU 476 476 476 LEU LEU A . n 
A 1 477 ASP 477 477 477 ASP ASP A . n 
A 1 478 THR 478 478 478 THR THR A . n 
A 1 479 TYR 479 479 479 TYR TYR A . n 
A 1 480 CYS 480 480 480 CYS CYS A . n 
A 1 481 PHE 481 481 481 PHE PHE A . n 
A 1 482 LEU 482 482 482 LEU LEU A . n 
A 1 483 VAL 483 483 483 VAL VAL A . n 
A 1 484 PHE 484 484 484 PHE PHE A . n 
A 1 485 ALA 485 485 485 ALA ALA A . n 
A 1 486 THR 486 486 486 THR THR A . n 
A 1 487 ILE 487 487 487 ILE ILE A . n 
A 1 488 CYS 488 488 488 CYS CYS A . n 
A 1 489 ILE 489 489 489 ILE ILE A . n 
A 1 490 THR 490 490 490 THR THR A . n 
A 1 491 GLY 491 491 491 GLY GLY A . n 
A 1 492 ALA 492 492 492 ALA ALA A . n 
A 1 493 ILE 493 493 493 ILE ILE A . n 
A 1 494 TYR 494 494 494 TYR TYR A . n 
A 1 495 LEU 495 495 495 LEU LEU A . n 
A 1 496 TYR 496 496 496 TYR TYR A . n 
A 1 497 PHE 497 497 497 PHE PHE A . n 
A 1 498 VAL 498 498 498 VAL VAL A . n 
A 1 499 LEU 499 499 499 LEU LEU A . n 
A 1 500 PRO 500 500 500 PRO PRO A . n 
A 1 501 GLU 501 501 501 GLU GLU A . n 
A 1 502 THR 502 502 502 THR THR A . n 
A 1 503 LYS 503 503 503 LYS LYS A . n 
A 1 504 ASN 504 504 504 ASN ASN A . n 
A 1 505 ARG 505 505 505 ARG ARG A . n 
A 1 506 THR 506 506 506 THR THR A . n 
A 1 507 TYR 507 507 507 TYR TYR A . n 
A 1 508 ALA 508 508 508 ALA ALA A . n 
A 1 509 GLU 509 509 509 GLU GLU A . n 
A 1 510 ILE 510 510 510 ILE ILE A . n 
A 1 511 SER 511 511 511 SER SER A . n 
A 1 512 GLN 512 512 512 GLN GLN A . n 
A 1 513 ALA 513 513 513 ALA ALA A . n 
A 1 514 PHE 514 514 514 PHE PHE A . n 
A 1 515 SER 515 515 515 SER SER A . n 
A 1 516 LYS 516 516 516 LYS LYS A . n 
A 1 517 ARG 517 517 517 ARG ARG A . n 
A 1 518 ASN 518 518 518 ASN ASN A . n 
A 1 519 LYS 519 519 519 LYS LYS A . n 
A 1 520 ALA 520 520 520 ALA ALA A . n 
A 1 521 TYR 521 521 521 TYR TYR A . n 
A 1 522 PRO 522 522 522 PRO PRO A . n 
A 1 523 PRO 523 523 ?   ?   ?   A . n 
A 1 524 GLU 524 524 ?   ?   ?   A . n 
A 1 525 GLU 525 525 ?   ?   ?   A . n 
A 1 526 LYS 526 526 ?   ?   ?   A . n 
A 1 527 ILE 527 527 ?   ?   ?   A . n 
A 1 528 ASP 528 528 ?   ?   ?   A . n 
A 1 529 SER 529 529 ?   ?   ?   A . n 
A 1 530 ALA 530 530 ?   ?   ?   A . n 
A 1 531 VAL 531 531 ?   ?   ?   A . n 
A 1 532 THR 532 532 ?   ?   ?   A . n 
A 1 533 ASP 533 533 ?   ?   ?   A . n 
A 1 534 GLY 534 534 ?   ?   ?   A . n 
A 1 535 LYS 535 535 ?   ?   ?   A . n 
A 1 536 ILE 536 536 ?   ?   ?   A . n 
A 1 537 ASN 537 537 ?   ?   ?   A . n 
A 1 538 GLY 538 538 ?   ?   ?   A . n 
A 1 539 ARG 539 539 ?   ?   ?   A . n 
A 1 540 PRO 540 540 ?   ?   ?   A . n 
A 1 541 GLY 541 541 ?   ?   ?   A . n 
A 1 542 THR 542 542 ?   ?   ?   A . n 
A 1 543 GLU 543 543 ?   ?   ?   A . n 
A 1 544 ASN 544 544 ?   ?   ?   A . n 
A 1 545 LEU 545 545 ?   ?   ?   A . n 
A 1 546 TYR 546 546 ?   ?   ?   A . n 
A 1 547 PHE 547 547 ?   ?   ?   A . n 
A 1 548 GLN 548 548 ?   ?   ?   A . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
B 2 NAG 1 B NAG 1 A NAG 523 n 
B 2 NAG 2 B NAG 2 A NAG 524 n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        URC 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   URC 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         C 
_pdbx_nonpoly_scheme.entity_id       3 
_pdbx_nonpoly_scheme.mon_id          URC 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     601 
_pdbx_nonpoly_scheme.auth_seq_num    1 
_pdbx_nonpoly_scheme.pdb_mon_id      URC 
_pdbx_nonpoly_scheme.auth_mon_id     URC 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZXM 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZXM 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZXM 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               127.209 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.790 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  'HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZXM 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.39 
_refine.ls_d_res_low                             3.39 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     29278 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    100.00 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.42055 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.42055 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'PARAMETERS FOR MASK CACLULATION' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD WITH PHASES' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.695 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             16.093 
_refine.overall_SU_ML                            0.253 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'ELECTRON MICROSCOPY' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       . 
_refine_hist.d_res_low                        . 
_refine_hist.number_atoms_solvent             ? 
_refine_hist.number_atoms_total               3666 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        ? 
_refine_hist.pdbx_number_atoms_nucleic_acid   ? 
_refine_hist.pdbx_number_atoms_ligand         ? 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.006  0.011  3762  ? r_bond_refined_d             ? ? 
'ELECTRON MICROSCOPY' ? 0.000  0.016  3675  ? r_bond_other_d               ? ? 
'ELECTRON MICROSCOPY' ? 1.525  1.637  5132  ? r_angle_refined_deg          ? ? 
'ELECTRON MICROSCOPY' ? 0.491  1.555  8432  ? r_angle_other_deg            ? ? 
'ELECTRON MICROSCOPY' ? 6.446  5.000  470   ? r_dihedral_angle_1_deg       ? ? 
'ELECTRON MICROSCOPY' ? 3.429  5.000  18    ? r_dihedral_angle_2_deg       ? ? 
'ELECTRON MICROSCOPY' ? 14.526 10.000 594   ? r_dihedral_angle_3_deg       ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_dihedral_angle_4_deg       ? ? 
'ELECTRON MICROSCOPY' ? 0.082  0.200  606   ? r_chiral_restr               ? ? 
'ELECTRON MICROSCOPY' ? 0.006  0.020  4323  ? r_gen_planes_refined         ? ? 
'ELECTRON MICROSCOPY' ? 0.001  0.020  875   ? r_gen_planes_other           ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'ELECTRON MICROSCOPY' ? 14.667 11.135 1883  ? r_mcbond_it                  ? ? 
'ELECTRON MICROSCOPY' ? 14.666 11.136 1883  ? r_mcbond_other               ? ? 
'ELECTRON MICROSCOPY' ? 21.987 20.176 2352  ? r_mcangle_it                 ? ? 
'ELECTRON MICROSCOPY' ? 21.987 20.188 2353  ? r_mcangle_other              ? ? 
'ELECTRON MICROSCOPY' ? 19.479 13.961 1879  ? r_scbond_it                  ? ? 
'ELECTRON MICROSCOPY' ? 19.475 13.961 1879  ? r_scbond_other               ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'ELECTRON MICROSCOPY' ? 30.355 24.557 2781  ? r_scangle_other              ? ? 
'ELECTRON MICROSCOPY' ? 36.197 139.58 14951 ? r_long_range_B_refined       ? ? 
'ELECTRON MICROSCOPY' ? 36.197 139.58 14952 ? r_long_range_B_other         ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'ELECTRON MICROSCOPY' 
_refine_ls_shell.d_res_high                       3.300 
_refine_ls_shell.d_res_low                        3.386 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             0 
_refine_ls_shell.number_reflns_R_work             2178 
_refine_ls_shell.percent_reflns_obs               100.00 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  2.365 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.000 
# 
_struct.entry_id                     8ZXM 
_struct.title                        'Cryo-EM structure of human GLUT9 bound to urate' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZXM 
_struct_keywords.text            'Urate, Transporter, Hypouricemia, RHUC, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    GTR9_HUMAN 
_struct_ref.pdbx_db_accession          Q9NRM0 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNA
PTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQ
AGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVV
PAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTV
IVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTI
TLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYC
FLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8ZXM 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 540 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q9NRM0 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  540 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       540 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZXM GLY A 541 ? UNP Q9NRM0 ? ? 'expression tag' 541 1 
1 8ZXM THR A 542 ? UNP Q9NRM0 ? ? 'expression tag' 542 2 
1 8ZXM GLU A 543 ? UNP Q9NRM0 ? ? 'expression tag' 543 3 
1 8ZXM ASN A 544 ? UNP Q9NRM0 ? ? 'expression tag' 544 4 
1 8ZXM LEU A 545 ? UNP Q9NRM0 ? ? 'expression tag' 545 5 
1 8ZXM TYR A 546 ? UNP Q9NRM0 ? ? 'expression tag' 546 6 
1 8ZXM PHE A 547 ? UNP Q9NRM0 ? ? 'expression tag' 547 7 
1 8ZXM GLN A 548 ? UNP Q9NRM0 ? ? 'expression tag' 548 8 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 53  ? PHE A 65  ? SER A 53  PHE A 65  1 ? 13 
HELX_P HELX_P2  AA2 SER A 68  ? LEU A 75  ? SER A 68  LEU A 75  1 ? 8  
HELX_P HELX_P3  AA3 PRO A 81  ? GLY A 98  ? PRO A 81  GLY A 98  1 ? 18 
HELX_P HELX_P4  AA4 ASP A 102 ? GLY A 132 ? ASP A 102 GLY A 132 1 ? 31 
HELX_P HELX_P5  AA5 GLY A 136 ? ASN A 144 ? GLY A 136 ASN A 144 1 ? 9  
HELX_P HELX_P6  AA6 ASN A 144 ? ALA A 156 ? ASN A 144 ALA A 156 1 ? 13 
HELX_P HELX_P7  AA7 CYS A 157 ? GLY A 162 ? CYS A 157 GLY A 162 1 ? 6  
HELX_P HELX_P8  AA8 PHE A 164 ? SER A 193 ? PHE A 164 SER A 193 1 ? 30 
HELX_P HELX_P9  AA9 SER A 200 ? LEU A 219 ? SER A 200 LEU A 219 1 ? 20 
HELX_P HELX_P10 AB1 TRP A 231 ? VAL A 237 ? TRP A 231 VAL A 237 1 ? 7  
HELX_P HELX_P11 AB2 ILE A 238 ? LEU A 247 ? ILE A 238 LEU A 247 1 ? 10 
HELX_P HELX_P12 AB3 SER A 248 ? LEU A 252 ? SER A 248 LEU A 252 5 ? 5  
HELX_P HELX_P13 AB4 ARG A 257 ? GLU A 262 ? ARG A 257 GLU A 262 1 ? 6  
HELX_P HELX_P14 AB5 ASN A 265 ? GLY A 278 ? ASN A 265 GLY A 278 1 ? 14 
HELX_P HELX_P15 AB6 VAL A 282 ? ARG A 297 ? VAL A 282 ARG A 297 1 ? 16 
HELX_P HELX_P16 AB7 SER A 303 ? LEU A 308 ? SER A 303 LEU A 308 1 ? 6  
HELX_P HELX_P17 AB8 ALA A 310 ? TYR A 312 ? ALA A 310 TYR A 312 5 ? 3  
HELX_P HELX_P18 AB9 VAL A 313 ? CYS A 330 ? VAL A 313 CYS A 330 1 ? 18 
HELX_P HELX_P19 AC1 GLY A 331 ? TYR A 338 ? GLY A 331 TYR A 338 1 ? 8  
HELX_P HELX_P20 AC2 TYR A 338 ? GLY A 347 ? TYR A 338 GLY A 347 1 ? 10 
HELX_P HELX_P21 AC3 LYS A 352 ? PHE A 370 ? LYS A 352 PHE A 370 1 ? 19 
HELX_P HELX_P22 AC4 SER A 371 ? GLY A 379 ? SER A 371 GLY A 379 1 ? 9  
HELX_P HELX_P23 AC5 ARG A 380 ? LEU A 404 ? ARG A 380 LEU A 404 1 ? 25 
HELX_P HELX_P24 AC6 VAL A 411 ? SER A 428 ? VAL A 411 SER A 428 1 ? 18 
HELX_P HELX_P25 AC7 GLY A 429 ? GLY A 432 ? GLY A 429 GLY A 432 5 ? 4  
HELX_P HELX_P26 AC8 ILE A 433 ? PHE A 441 ? ILE A 433 PHE A 441 1 ? 9  
HELX_P HELX_P27 AC9 GLN A 446 ? LEU A 467 ? GLN A 446 LEU A 467 1 ? 22 
HELX_P HELX_P28 AD1 LEU A 468 ? ASP A 477 ? LEU A 468 ASP A 477 1 ? 10 
HELX_P HELX_P29 AD2 THR A 478 ? CYS A 480 ? THR A 478 CYS A 480 5 ? 3  
HELX_P HELX_P30 AD3 PHE A 481 ? LEU A 499 ? PHE A 481 LEU A 499 1 ? 19 
HELX_P HELX_P31 AD4 THR A 506 ? LYS A 519 ? THR A 506 LYS A 519 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale one  ? A ASN 90 ND2 ? ? ? 1_555 B NAG . C1 ? ? A ASN 90 B NAG 1 1_555 ? ? ? ? ? ? ? 1.420 ? N-Glycosylation 
covale2 covale both ? B NAG .  O4  ? ? ? 1_555 B NAG . C1 ? ? B NAG 1  B NAG 2 1_555 ? ? ? ? ? ? ? 1.391 ? ?               
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      NAG 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     ASN 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      90 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       NAG 
_pdbx_modification_feature.auth_asym_id                       B 
_pdbx_modification_feature.auth_seq_id                        1 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      ASN 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       90 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C1 
_pdbx_modification_feature.modified_residue_id_linking_atom   ND2 
_pdbx_modification_feature.modified_residue_id                ASN 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        NAG 
_pdbx_modification_feature.type                               N-Glycosylation 
_pdbx_modification_feature.category                           Carbohydrate 
# 
_pdbx_entry_details.entry_id                   8ZXM 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER A 67  ? ? -139.10 -33.25  
2 1 ARG A 96  ? ? -130.12 -41.92  
3 1 LYS A 195 ? ? -78.12  21.98   
4 1 LEU A 224 ? ? -105.27 -125.11 
5 1 SER A 248 ? ? -135.67 -50.50  
6 1 GLU A 262 ? ? -130.33 -35.96  
7 1 LEU A 404 ? ? -94.67  30.97   
8 1 ASP A 477 ? ? 55.00   -116.74 
9 1 VAL A 498 ? ? -132.05 -52.69  
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8ZXM 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8ZXM 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.39 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               180531 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            8.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Glucose transporter 9' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8ZXM 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             1600 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8ZXM 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8ZXM 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ALA 2   ? A ALA 2   
3  1 Y 1 A ARG 3   ? A ARG 3   
4  1 Y 1 A LYS 4   ? A LYS 4   
5  1 Y 1 A GLN 5   ? A GLN 5   
6  1 Y 1 A ASN 6   ? A ASN 6   
7  1 Y 1 A ARG 7   ? A ARG 7   
8  1 Y 1 A ASN 8   ? A ASN 8   
9  1 Y 1 A SER 9   ? A SER 9   
10 1 Y 1 A LYS 10  ? A LYS 10  
11 1 Y 1 A GLU 11  ? A GLU 11  
12 1 Y 1 A LEU 12  ? A LEU 12  
13 1 Y 1 A GLY 13  ? A GLY 13  
14 1 Y 1 A LEU 14  ? A LEU 14  
15 1 Y 1 A VAL 15  ? A VAL 15  
16 1 Y 1 A PRO 16  ? A PRO 16  
17 1 Y 1 A LEU 17  ? A LEU 17  
18 1 Y 1 A THR 18  ? A THR 18  
19 1 Y 1 A ASP 19  ? A ASP 19  
20 1 Y 1 A ASP 20  ? A ASP 20  
21 1 Y 1 A THR 21  ? A THR 21  
22 1 Y 1 A SER 22  ? A SER 22  
23 1 Y 1 A HIS 23  ? A HIS 23  
24 1 Y 1 A ALA 24  ? A ALA 24  
25 1 Y 1 A GLY 25  ? A GLY 25  
26 1 Y 1 A PRO 26  ? A PRO 26  
27 1 Y 1 A PRO 27  ? A PRO 27  
28 1 Y 1 A GLY 28  ? A GLY 28  
29 1 Y 1 A PRO 29  ? A PRO 29  
30 1 Y 1 A GLY 30  ? A GLY 30  
31 1 Y 1 A ARG 31  ? A ARG 31  
32 1 Y 1 A ALA 32  ? A ALA 32  
33 1 Y 1 A LEU 33  ? A LEU 33  
34 1 Y 1 A LEU 34  ? A LEU 34  
35 1 Y 1 A GLU 35  ? A GLU 35  
36 1 Y 1 A CYS 36  ? A CYS 36  
37 1 Y 1 A ASP 37  ? A ASP 37  
38 1 Y 1 A HIS 38  ? A HIS 38  
39 1 Y 1 A LEU 39  ? A LEU 39  
40 1 Y 1 A ARG 40  ? A ARG 40  
41 1 Y 1 A SER 41  ? A SER 41  
42 1 Y 1 A GLY 42  ? A GLY 42  
43 1 Y 1 A VAL 43  ? A VAL 43  
44 1 Y 1 A PRO 44  ? A PRO 44  
45 1 Y 1 A GLY 45  ? A GLY 45  
46 1 Y 1 A GLY 46  ? A GLY 46  
47 1 Y 1 A ARG 47  ? A ARG 47  
48 1 Y 1 A ARG 48  ? A ARG 48  
49 1 Y 1 A ARG 49  ? A ARG 49  
50 1 Y 1 A LYS 50  ? A LYS 50  
51 1 Y 1 A ASP 51  ? A ASP 51  
52 1 Y 1 A PRO 523 ? A PRO 523 
53 1 Y 1 A GLU 524 ? A GLU 524 
54 1 Y 1 A GLU 525 ? A GLU 525 
55 1 Y 1 A LYS 526 ? A LYS 526 
56 1 Y 1 A ILE 527 ? A ILE 527 
57 1 Y 1 A ASP 528 ? A ASP 528 
58 1 Y 1 A SER 529 ? A SER 529 
59 1 Y 1 A ALA 530 ? A ALA 530 
60 1 Y 1 A VAL 531 ? A VAL 531 
61 1 Y 1 A THR 532 ? A THR 532 
62 1 Y 1 A ASP 533 ? A ASP 533 
63 1 Y 1 A GLY 534 ? A GLY 534 
64 1 Y 1 A LYS 535 ? A LYS 535 
65 1 Y 1 A ILE 536 ? A ILE 536 
66 1 Y 1 A ASN 537 ? A ASN 537 
67 1 Y 1 A GLY 538 ? A GLY 538 
68 1 Y 1 A ARG 539 ? A ARG 539 
69 1 Y 1 A PRO 540 ? A PRO 540 
70 1 Y 1 A GLY 541 ? A GLY 541 
71 1 Y 1 A THR 542 ? A THR 542 
72 1 Y 1 A GLU 543 ? A GLU 543 
73 1 Y 1 A ASN 544 ? A ASN 544 
74 1 Y 1 A LEU 545 ? A LEU 545 
75 1 Y 1 A TYR 546 ? A TYR 546 
76 1 Y 1 A PHE 547 ? A PHE 547 
77 1 Y 1 A GLN 548 ? A GLN 548 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
NAG C1   C N R 247 
NAG C2   C N R 248 
NAG C3   C N R 249 
NAG C4   C N S 250 
NAG C5   C N R 251 
NAG C6   C N N 252 
NAG C7   C N N 253 
NAG C8   C N N 254 
NAG N2   N N N 255 
NAG O1   O N N 256 
NAG O3   O N N 257 
NAG O4   O N N 258 
NAG O5   O N N 259 
NAG O6   O N N 260 
NAG O7   O N N 261 
NAG H1   H N N 262 
NAG H2   H N N 263 
NAG H3   H N N 264 
NAG H4   H N N 265 
NAG H5   H N N 266 
NAG H61  H N N 267 
NAG H62  H N N 268 
NAG H81  H N N 269 
NAG H82  H N N 270 
NAG H83  H N N 271 
NAG HN2  H N N 272 
NAG HO1  H N N 273 
NAG HO3  H N N 274 
NAG HO4  H N N 275 
NAG HO6  H N N 276 
PHE N    N N N 277 
PHE CA   C N S 278 
PHE C    C N N 279 
PHE O    O N N 280 
PHE CB   C N N 281 
PHE CG   C Y N 282 
PHE CD1  C Y N 283 
PHE CD2  C Y N 284 
PHE CE1  C Y N 285 
PHE CE2  C Y N 286 
PHE CZ   C Y N 287 
PHE OXT  O N N 288 
PHE H    H N N 289 
PHE H2   H N N 290 
PHE HA   H N N 291 
PHE HB2  H N N 292 
PHE HB3  H N N 293 
PHE HD1  H N N 294 
PHE HD2  H N N 295 
PHE HE1  H N N 296 
PHE HE2  H N N 297 
PHE HZ   H N N 298 
PHE HXT  H N N 299 
PRO N    N N N 300 
PRO CA   C N S 301 
PRO C    C N N 302 
PRO O    O N N 303 
PRO CB   C N N 304 
PRO CG   C N N 305 
PRO CD   C N N 306 
PRO OXT  O N N 307 
PRO H    H N N 308 
PRO HA   H N N 309 
PRO HB2  H N N 310 
PRO HB3  H N N 311 
PRO HG2  H N N 312 
PRO HG3  H N N 313 
PRO HD2  H N N 314 
PRO HD3  H N N 315 
PRO HXT  H N N 316 
SER N    N N N 317 
SER CA   C N S 318 
SER C    C N N 319 
SER O    O N N 320 
SER CB   C N N 321 
SER OG   O N N 322 
SER OXT  O N N 323 
SER H    H N N 324 
SER H2   H N N 325 
SER HA   H N N 326 
SER HB2  H N N 327 
SER HB3  H N N 328 
SER HG   H N N 329 
SER HXT  H N N 330 
THR N    N N N 331 
THR CA   C N S 332 
THR C    C N N 333 
THR O    O N N 334 
THR CB   C N R 335 
THR OG1  O N N 336 
THR CG2  C N N 337 
THR OXT  O N N 338 
THR H    H N N 339 
THR H2   H N N 340 
THR HA   H N N 341 
THR HB   H N N 342 
THR HG1  H N N 343 
THR HG21 H N N 344 
THR HG22 H N N 345 
THR HG23 H N N 346 
THR HXT  H N N 347 
TRP N    N N N 348 
TRP CA   C N S 349 
TRP C    C N N 350 
TRP O    O N N 351 
TRP CB   C N N 352 
TRP CG   C Y N 353 
TRP CD1  C Y N 354 
TRP CD2  C Y N 355 
TRP NE1  N Y N 356 
TRP CE2  C Y N 357 
TRP CE3  C Y N 358 
TRP CZ2  C Y N 359 
TRP CZ3  C Y N 360 
TRP CH2  C Y N 361 
TRP OXT  O N N 362 
TRP H    H N N 363 
TRP H2   H N N 364 
TRP HA   H N N 365 
TRP HB2  H N N 366 
TRP HB3  H N N 367 
TRP HD1  H N N 368 
TRP HE1  H N N 369 
TRP HE3  H N N 370 
TRP HZ2  H N N 371 
TRP HZ3  H N N 372 
TRP HH2  H N N 373 
TRP HXT  H N N 374 
TYR N    N N N 375 
TYR CA   C N S 376 
TYR C    C N N 377 
TYR O    O N N 378 
TYR CB   C N N 379 
TYR CG   C Y N 380 
TYR CD1  C Y N 381 
TYR CD2  C Y N 382 
TYR CE1  C Y N 383 
TYR CE2  C Y N 384 
TYR CZ   C Y N 385 
TYR OH   O N N 386 
TYR OXT  O N N 387 
TYR H    H N N 388 
TYR H2   H N N 389 
TYR HA   H N N 390 
TYR HB2  H N N 391 
TYR HB3  H N N 392 
TYR HD1  H N N 393 
TYR HD2  H N N 394 
TYR HE1  H N N 395 
TYR HE2  H N N 396 
TYR HH   H N N 397 
TYR HXT  H N N 398 
URC N1   N Y N 399 
URC C2   C Y N 400 
URC C6   C Y N 401 
URC N3   N Y N 402 
URC O11  O N N 403 
URC C4   C Y N 404 
URC C5   C Y N 405 
URC N9   N Y N 406 
URC O13  O N N 407 
URC N7   N Y N 408 
URC C8   C Y N 409 
URC O24  O N N 410 
URC HN1  H N N 411 
URC HN3  H N N 412 
URC HN9  H N N 413 
URC HN7  H N N 414 
VAL N    N N N 415 
VAL CA   C N S 416 
VAL C    C N N 417 
VAL O    O N N 418 
VAL CB   C N N 419 
VAL CG1  C N N 420 
VAL CG2  C N N 421 
VAL OXT  O N N 422 
VAL H    H N N 423 
VAL H2   H N N 424 
VAL HA   H N N 425 
VAL HB   H N N 426 
VAL HG11 H N N 427 
VAL HG12 H N N 428 
VAL HG13 H N N 429 
VAL HG21 H N N 430 
VAL HG22 H N N 431 
VAL HG23 H N N 432 
VAL HXT  H N N 433 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
NAG C1  C2   sing N N 235 
NAG C1  O1   sing N N 236 
NAG C1  O5   sing N N 237 
NAG C1  H1   sing N N 238 
NAG C2  C3   sing N N 239 
NAG C2  N2   sing N N 240 
NAG C2  H2   sing N N 241 
NAG C3  C4   sing N N 242 
NAG C3  O3   sing N N 243 
NAG C3  H3   sing N N 244 
NAG C4  C5   sing N N 245 
NAG C4  O4   sing N N 246 
NAG C4  H4   sing N N 247 
NAG C5  C6   sing N N 248 
NAG C5  O5   sing N N 249 
NAG C5  H5   sing N N 250 
NAG C6  O6   sing N N 251 
NAG C6  H61  sing N N 252 
NAG C6  H62  sing N N 253 
NAG C7  C8   sing N N 254 
NAG C7  N2   sing N N 255 
NAG C7  O7   doub N N 256 
NAG C8  H81  sing N N 257 
NAG C8  H82  sing N N 258 
NAG C8  H83  sing N N 259 
NAG N2  HN2  sing N N 260 
NAG O1  HO1  sing N N 261 
NAG O3  HO3  sing N N 262 
NAG O4  HO4  sing N N 263 
NAG O6  HO6  sing N N 264 
PHE N   CA   sing N N 265 
PHE N   H    sing N N 266 
PHE N   H2   sing N N 267 
PHE CA  C    sing N N 268 
PHE CA  CB   sing N N 269 
PHE CA  HA   sing N N 270 
PHE C   O    doub N N 271 
PHE C   OXT  sing N N 272 
PHE CB  CG   sing N N 273 
PHE CB  HB2  sing N N 274 
PHE CB  HB3  sing N N 275 
PHE CG  CD1  doub Y N 276 
PHE CG  CD2  sing Y N 277 
PHE CD1 CE1  sing Y N 278 
PHE CD1 HD1  sing N N 279 
PHE CD2 CE2  doub Y N 280 
PHE CD2 HD2  sing N N 281 
PHE CE1 CZ   doub Y N 282 
PHE CE1 HE1  sing N N 283 
PHE CE2 CZ   sing Y N 284 
PHE CE2 HE2  sing N N 285 
PHE CZ  HZ   sing N N 286 
PHE OXT HXT  sing N N 287 
PRO N   CA   sing N N 288 
PRO N   CD   sing N N 289 
PRO N   H    sing N N 290 
PRO CA  C    sing N N 291 
PRO CA  CB   sing N N 292 
PRO CA  HA   sing N N 293 
PRO C   O    doub N N 294 
PRO C   OXT  sing N N 295 
PRO CB  CG   sing N N 296 
PRO CB  HB2  sing N N 297 
PRO CB  HB3  sing N N 298 
PRO CG  CD   sing N N 299 
PRO CG  HG2  sing N N 300 
PRO CG  HG3  sing N N 301 
PRO CD  HD2  sing N N 302 
PRO CD  HD3  sing N N 303 
PRO OXT HXT  sing N N 304 
SER N   CA   sing N N 305 
SER N   H    sing N N 306 
SER N   H2   sing N N 307 
SER CA  C    sing N N 308 
SER CA  CB   sing N N 309 
SER CA  HA   sing N N 310 
SER C   O    doub N N 311 
SER C   OXT  sing N N 312 
SER CB  OG   sing N N 313 
SER CB  HB2  sing N N 314 
SER CB  HB3  sing N N 315 
SER OG  HG   sing N N 316 
SER OXT HXT  sing N N 317 
THR N   CA   sing N N 318 
THR N   H    sing N N 319 
THR N   H2   sing N N 320 
THR CA  C    sing N N 321 
THR CA  CB   sing N N 322 
THR CA  HA   sing N N 323 
THR C   O    doub N N 324 
THR C   OXT  sing N N 325 
THR CB  OG1  sing N N 326 
THR CB  CG2  sing N N 327 
THR CB  HB   sing N N 328 
THR OG1 HG1  sing N N 329 
THR CG2 HG21 sing N N 330 
THR CG2 HG22 sing N N 331 
THR CG2 HG23 sing N N 332 
THR OXT HXT  sing N N 333 
TRP N   CA   sing N N 334 
TRP N   H    sing N N 335 
TRP N   H2   sing N N 336 
TRP CA  C    sing N N 337 
TRP CA  CB   sing N N 338 
TRP CA  HA   sing N N 339 
TRP C   O    doub N N 340 
TRP C   OXT  sing N N 341 
TRP CB  CG   sing N N 342 
TRP CB  HB2  sing N N 343 
TRP CB  HB3  sing N N 344 
TRP CG  CD1  doub Y N 345 
TRP CG  CD2  sing Y N 346 
TRP CD1 NE1  sing Y N 347 
TRP CD1 HD1  sing N N 348 
TRP CD2 CE2  doub Y N 349 
TRP CD2 CE3  sing Y N 350 
TRP NE1 CE2  sing Y N 351 
TRP NE1 HE1  sing N N 352 
TRP CE2 CZ2  sing Y N 353 
TRP CE3 CZ3  doub Y N 354 
TRP CE3 HE3  sing N N 355 
TRP CZ2 CH2  doub Y N 356 
TRP CZ2 HZ2  sing N N 357 
TRP CZ3 CH2  sing Y N 358 
TRP CZ3 HZ3  sing N N 359 
TRP CH2 HH2  sing N N 360 
TRP OXT HXT  sing N N 361 
TYR N   CA   sing N N 362 
TYR N   H    sing N N 363 
TYR N   H2   sing N N 364 
TYR CA  C    sing N N 365 
TYR CA  CB   sing N N 366 
TYR CA  HA   sing N N 367 
TYR C   O    doub N N 368 
TYR C   OXT  sing N N 369 
TYR CB  CG   sing N N 370 
TYR CB  HB2  sing N N 371 
TYR CB  HB3  sing N N 372 
TYR CG  CD1  doub Y N 373 
TYR CG  CD2  sing Y N 374 
TYR CD1 CE1  sing Y N 375 
TYR CD1 HD1  sing N N 376 
TYR CD2 CE2  doub Y N 377 
TYR CD2 HD2  sing N N 378 
TYR CE1 CZ   doub Y N 379 
TYR CE1 HE1  sing N N 380 
TYR CE2 CZ   sing Y N 381 
TYR CE2 HE2  sing N N 382 
TYR CZ  OH   sing N N 383 
TYR OH  HH   sing N N 384 
TYR OXT HXT  sing N N 385 
URC N1  C2   sing Y N 386 
URC N1  C6   sing Y N 387 
URC N1  HN1  sing N N 388 
URC C2  N3   sing Y N 389 
URC C2  O11  doub N N 390 
URC C6  C5   sing Y N 391 
URC C6  O13  doub N N 392 
URC N3  C4   sing Y N 393 
URC N3  HN3  sing N N 394 
URC C4  C5   doub Y N 395 
URC C4  N9   sing Y N 396 
URC C5  N7   sing Y N 397 
URC N9  C8   sing Y N 398 
URC N9  HN9  sing N N 399 
URC N7  C8   sing Y N 400 
URC N7  HN7  sing N N 401 
URC C8  O24  doub N N 402 
VAL N   CA   sing N N 403 
VAL N   H    sing N N 404 
VAL N   H2   sing N N 405 
VAL CA  C    sing N N 406 
VAL CA  CB   sing N N 407 
VAL CA  HA   sing N N 408 
VAL C   O    doub N N 409 
VAL C   OXT  sing N N 410 
VAL CB  CG1  sing N N 411 
VAL CB  CG2  sing N N 412 
VAL CB  HB   sing N N 413 
VAL CG1 HG11 sing N N 414 
VAL CG1 HG12 sing N N 415 
VAL CG1 HG13 sing N N 416 
VAL CG2 HG21 sing N N 417 
VAL CG2 HG22 sing N N 418 
VAL CG2 HG23 sing N N 419 
VAL OXT HXT  sing N N 420 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-06-14 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8ZXM 
_em_admin.last_update        2025-04-16 
_em_admin.map_release_date   2025-04-16 
_em_admin.title              'Cryo-EM structure of human GLUT9 bound to urate' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                KILODALTONS/NANOMETER 
_em_entity_assembly_molwt.value                60 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         51 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Society for the Promotion of Science (JSPS)' Japan 24K18064   1 
'Japan Society for the Promotion of Science (JSPS)' Japan 23K27132   2 
'Japan Society for the Promotion of Science (JSPS)' Japan 24H02264   3 
'Japan Science and Technology'                      Japan JPMJPR21EF 4 
'Japan Society for the Promotion of Science (JSPS)' Japan 21K15031   5 
'Japan Society for the Promotion of Science (JSPS)' Japan 20H03216   6 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
2 NAG 1 n 
2 NAG 2 n 
# 
_atom_sites.entry_id                    8ZXM 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . TRP A 1 52  ? 84.766  88.585  97.555  1.00 241.30 ? 52  TRP A N   1 
ATOM   2    C CA  . TRP A 1 52  ? 85.864  89.053  96.666  1.00 227.73 ? 52  TRP A CA  1 
ATOM   3    C C   . TRP A 1 52  ? 85.573  88.658  95.217  1.00 215.88 ? 52  TRP A C   1 
ATOM   4    O O   . TRP A 1 52  ? 84.801  87.735  94.955  1.00 215.47 ? 52  TRP A O   1 
ATOM   5    C CB  . TRP A 1 52  ? 87.217  88.489  97.136  1.00 220.83 ? 52  TRP A CB  1 
ATOM   6    C CG  . TRP A 1 52  ? 87.717  89.048  98.447  1.00 227.52 ? 52  TRP A CG  1 
ATOM   7    C CD1 . TRP A 1 52  ? 87.470  88.533  99.688  1.00 231.20 ? 52  TRP A CD1 1 
ATOM   8    C CD2 . TRP A 1 52  ? 88.579  90.195  98.657  1.00 247.55 ? 52  TRP A CD2 1 
ATOM   9    N NE1 . TRP A 1 52  ? 88.088  89.284  100.651 1.00 235.13 ? 52  TRP A NE1 1 
ATOM   10   C CE2 . TRP A 1 52  ? 88.775  90.310  100.054 1.00 249.70 ? 52  TRP A CE2 1 
ATOM   11   C CE3 . TRP A 1 52  ? 89.188  91.143  97.822  1.00 259.20 ? 52  TRP A CE3 1 
ATOM   12   C CZ2 . TRP A 1 52  ? 89.554  91.323  100.618 1.00 253.86 ? 52  TRP A CZ2 1 
ATOM   13   C CZ3 . TRP A 1 52  ? 89.946  92.153  98.382  1.00 243.51 ? 52  TRP A CZ3 1 
ATOM   14   C CH2 . TRP A 1 52  ? 90.131  92.236  99.762  1.00 240.89 ? 52  TRP A CH2 1 
ATOM   15   N N   . SER A 1 53  ? 86.208  89.387  94.288  1.00 199.87 ? 53  SER A N   1 
ATOM   16   C CA  . SER A 1 53  ? 86.101  89.160  92.852  1.00 201.07 ? 53  SER A CA  1 
ATOM   17   C C   . SER A 1 53  ? 87.440  89.510  92.203  1.00 194.63 ? 53  SER A C   1 
ATOM   18   O O   . SER A 1 53  ? 88.211  90.269  92.786  1.00 209.43 ? 53  SER A O   1 
ATOM   19   C CB  . SER A 1 53  ? 84.986  89.976  92.261  1.00 193.80 ? 53  SER A CB  1 
ATOM   20   O OG  . SER A 1 53  ? 85.272  91.362  92.382  1.00 199.61 ? 53  SER A OG  1 
ATOM   21   N N   . CYS A 1 54  ? 87.715  88.991  90.996  1.00 182.21 ? 54  CYS A N   1 
ATOM   22   C CA  . CYS A 1 54  ? 89.029  89.135  90.387  1.00 185.26 ? 54  CYS A CA  1 
ATOM   23   C C   . CYS A 1 54  ? 89.416  90.614  90.254  1.00 148.22 ? 54  CYS A C   1 
ATOM   24   O O   . CYS A 1 54  ? 90.516  91.012  90.653  1.00 114.87 ? 54  CYS A O   1 
ATOM   25   C CB  . CYS A 1 54  ? 89.086  88.414  89.044  1.00 217.73 ? 54  CYS A CB  1 
ATOM   26   S SG  . CYS A 1 54  ? 90.733  88.441  88.286  1.00 238.96 ? 54  CYS A SG  1 
ATOM   27   N N   . SER A 1 55  ? 88.511  91.437  89.710  1.00 154.90 ? 55  SER A N   1 
ATOM   28   C CA  . SER A 1 55  ? 88.790  92.848  89.462  1.00 156.27 ? 55  SER A CA  1 
ATOM   29   C C   . SER A 1 55  ? 89.038  93.620  90.761  1.00 133.58 ? 55  SER A C   1 
ATOM   30   O O   . SER A 1 55  ? 89.796  94.585  90.755  1.00 145.61 ? 55  SER A O   1 
ATOM   31   C CB  . SER A 1 55  ? 87.687  93.482  88.646  1.00 131.59 ? 55  SER A CB  1 
ATOM   32   O OG  . SER A 1 55  ? 87.540  92.814  87.407  1.00 123.29 ? 55  SER A OG  1 
ATOM   33   N N   . LEU A 1 56  ? 88.425  93.198  91.873  1.00 117.59 ? 56  LEU A N   1 
ATOM   34   C CA  . LEU A 1 56  ? 88.638  93.853  93.155  1.00 119.81 ? 56  LEU A CA  1 
ATOM   35   C C   . LEU A 1 56  ? 89.985  93.453  93.765  1.00 124.56 ? 56  LEU A C   1 
ATOM   36   O O   . LEU A 1 56  ? 90.598  94.260  94.462  1.00 114.97 ? 56  LEU A O   1 
ATOM   37   C CB  . LEU A 1 56  ? 87.466  93.529  94.090  1.00 114.62 ? 56  LEU A CB  1 
ATOM   38   C CG  . LEU A 1 56  ? 87.537  94.129  95.495  1.00 97.29  ? 56  LEU A CG  1 
ATOM   39   C CD1 . LEU A 1 56  ? 87.611  95.643  95.443  1.00 112.94 ? 56  LEU A CD1 1 
ATOM   40   C CD2 . LEU A 1 56  ? 86.339  93.708  96.316  1.00 93.02  ? 56  LEU A CD2 1 
ATOM   41   N N   . LEU A 1 57  ? 90.465  92.229  93.503  1.00 133.13 ? 57  LEU A N   1 
ATOM   42   C CA  . LEU A 1 57  ? 91.788  91.821  93.955  1.00 146.80 ? 57  LEU A CA  1 
ATOM   43   C C   . LEU A 1 57  ? 92.854  92.647  93.239  1.00 134.23 ? 57  LEU A C   1 
ATOM   44   O O   . LEU A 1 57  ? 93.669  93.273  93.916  1.00 140.13 ? 57  LEU A O   1 
ATOM   45   C CB  . LEU A 1 57  ? 92.000  90.315  93.743  1.00 170.21 ? 57  LEU A CB  1 
ATOM   46   C CG  . LEU A 1 57  ? 91.259  89.405  94.722  1.00 221.44 ? 57  LEU A CG  1 
ATOM   47   C CD1 . LEU A 1 57  ? 91.351  87.951  94.275  1.00 246.03 ? 57  LEU A CD1 1 
ATOM   48   C CD2 . LEU A 1 57  ? 91.789  89.564  96.143  1.00 225.50 ? 57  LEU A CD2 1 
ATOM   49   N N   . VAL A 1 58  ? 92.855  92.690  91.896  1.00 121.48 ? 58  VAL A N   1 
ATOM   50   C CA  . VAL A 1 58  ? 93.906  93.409  91.188  1.00 125.64 ? 58  VAL A CA  1 
ATOM   51   C C   . VAL A 1 58  ? 93.802  94.916  91.438  1.00 107.65 ? 58  VAL A C   1 
ATOM   52   O O   . VAL A 1 58  ? 94.833  95.565  91.590  1.00 121.13 ? 58  VAL A O   1 
ATOM   53   C CB  . VAL A 1 58  ? 94.002  93.057  89.688  1.00 160.38 ? 58  VAL A CB  1 
ATOM   54   C CG1 . VAL A 1 58  ? 94.525  91.647  89.478  1.00 181.85 ? 58  VAL A CG1 1 
ATOM   55   C CG2 . VAL A 1 58  ? 92.701  93.228  88.939  1.00 193.24 ? 58  VAL A CG2 1 
ATOM   56   N N   . ALA A 1 59  ? 92.594  95.484  91.552  1.00 111.35 ? 59  ALA A N   1 
ATOM   57   C CA  . ALA A 1 59  ? 92.441  96.895  91.901  1.00 96.46  ? 59  ALA A CA  1 
ATOM   58   C C   . ALA A 1 59  ? 93.022  97.202  93.283  1.00 94.79  ? 59  ALA A C   1 
ATOM   59   O O   . ALA A 1 59  ? 93.542  98.297  93.487  1.00 87.29  ? 59  ALA A O   1 
ATOM   60   C CB  . ALA A 1 59  ? 90.979  97.301  91.824  1.00 99.34  ? 59  ALA A CB  1 
ATOM   61   N N   . SER A 1 60  ? 92.898  96.266  94.248  1.00 104.20 ? 60  SER A N   1 
ATOM   62   C CA  . SER A 1 60  ? 93.424  96.439  95.596  1.00 104.51 ? 60  SER A CA  1 
ATOM   63   C C   . SER A 1 60  ? 94.947  96.328  95.612  1.00 129.22 ? 60  SER A C   1 
ATOM   64   O O   . SER A 1 60  ? 95.619  97.174  96.217  1.00 141.51 ? 60  SER A O   1 
ATOM   65   C CB  . SER A 1 60  ? 92.834  95.442  96.556  1.00 121.19 ? 60  SER A CB  1 
ATOM   66   O OG  . SER A 1 60  ? 91.426  95.561  96.642  1.00 149.95 ? 60  SER A OG  1 
ATOM   67   N N   . LEU A 1 61  ? 95.478  95.269  94.972  1.00 136.60 ? 61  LEU A N   1 
ATOM   68   C CA  . LEU A 1 61  ? 96.903  94.956  95.020  1.00 121.73 ? 61  LEU A CA  1 
ATOM   69   C C   . LEU A 1 61  ? 97.698  95.874  94.089  1.00 114.39 ? 61  LEU A C   1 
ATOM   70   O O   . LEU A 1 61  ? 98.631  96.520  94.553  1.00 138.37 ? 61  LEU A O   1 
ATOM   71   C CB  . LEU A 1 61  ? 97.120  93.479  94.672  1.00 122.05 ? 61  LEU A CB  1 
ATOM   72   C CG  . LEU A 1 61  ? 96.522  92.477  95.655  1.00 124.80 ? 61  LEU A CG  1 
ATOM   73   C CD1 . LEU A 1 61  ? 96.738  91.050  95.153  1.00 151.03 ? 61  LEU A CD1 1 
ATOM   74   C CD2 . LEU A 1 61  ? 97.094  92.664  97.049  1.00 109.99 ? 61  LEU A CD2 1 
ATOM   75   N N   . ALA A 1 62  ? 97.362  95.945  92.792  1.00 91.04  ? 62  ALA A N   1 
ATOM   76   C CA  . ALA A 1 62  ? 98.089  96.806  91.873  1.00 102.06 ? 62  ALA A CA  1 
ATOM   77   C C   . ALA A 1 62  ? 97.808  98.289  92.135  1.00 110.07 ? 62  ALA A C   1 
ATOM   78   O O   . ALA A 1 62  ? 98.553  99.150  91.675  1.00 131.77 ? 62  ALA A O   1 
ATOM   79   C CB  . ALA A 1 62  ? 97.780  96.424  90.446  1.00 120.73 ? 62  ALA A CB  1 
ATOM   80   N N   . GLY A 1 63  ? 96.744  98.598  92.873  1.00 116.04 ? 63  GLY A N   1 
ATOM   81   C CA  . GLY A 1 63  ? 96.563  99.914  93.470  1.00 135.81 ? 63  GLY A CA  1 
ATOM   82   C C   . GLY A 1 63  ? 97.620  100.197 94.541  1.00 114.86 ? 63  GLY A C   1 
ATOM   83   O O   . GLY A 1 63  ? 98.394  101.136 94.405  1.00 146.96 ? 63  GLY A O   1 
ATOM   84   N N   . ALA A 1 64  ? 97.680  99.361  95.582  1.00 98.37  ? 64  ALA A N   1 
ATOM   85   C CA  . ALA A 1 64  ? 98.587  99.569  96.695  1.00 108.30 ? 64  ALA A CA  1 
ATOM   86   C C   . ALA A 1 64  ? 100.057 99.454  96.270  1.00 114.94 ? 64  ALA A C   1 
ATOM   87   O O   . ALA A 1 64  ? 100.889 100.230 96.742  1.00 141.70 ? 64  ALA A O   1 
ATOM   88   C CB  . ALA A 1 64  ? 98.244  98.594  97.806  1.00 135.64 ? 64  ALA A CB  1 
ATOM   89   N N   . PHE A 1 65  ? 100.400 98.509  95.379  1.00 102.60 ? 65  PHE A N   1 
ATOM   90   C CA  . PHE A 1 65  ? 101.779 98.168  95.053  1.00 113.98 ? 65  PHE A CA  1 
ATOM   91   C C   . PHE A 1 65  ? 102.501 99.296  94.315  1.00 123.35 ? 65  PHE A C   1 
ATOM   92   O O   . PHE A 1 65  ? 103.736 99.340  94.309  1.00 155.22 ? 65  PHE A O   1 
ATOM   93   C CB  . PHE A 1 65  ? 101.806 96.867  94.237  1.00 125.05 ? 65  PHE A CB  1 
ATOM   94   C CG  . PHE A 1 65  ? 103.173 96.317  93.906  1.00 138.90 ? 65  PHE A CG  1 
ATOM   95   C CD1 . PHE A 1 65  ? 104.047 95.875  94.902  1.00 149.45 ? 65  PHE A CD1 1 
ATOM   96   C CD2 . PHE A 1 65  ? 103.582 96.237  92.584  1.00 152.32 ? 65  PHE A CD2 1 
ATOM   97   C CE1 . PHE A 1 65  ? 105.315 95.424  94.576  1.00 160.30 ? 65  PHE A CE1 1 
ATOM   98   C CE2 . PHE A 1 65  ? 104.830 95.724  92.256  1.00 176.35 ? 65  PHE A CE2 1 
ATOM   99   C CZ  . PHE A 1 65  ? 105.702 95.339  93.254  1.00 178.15 ? 65  PHE A CZ  1 
ATOM   100  N N   . GLY A 1 66  ? 101.753 100.202 93.673  1.00 114.69 ? 66  GLY A N   1 
ATOM   101  C CA  . GLY A 1 66  ? 102.355 101.319 92.957  1.00 121.91 ? 66  GLY A CA  1 
ATOM   102  C C   . GLY A 1 66  ? 102.196 102.675 93.651  1.00 118.48 ? 66  GLY A C   1 
ATOM   103  O O   . GLY A 1 66  ? 102.680 103.673 93.135  1.00 102.32 ? 66  GLY A O   1 
ATOM   104  N N   . SER A 1 67  ? 101.542 102.712 94.828  1.00 97.02  ? 67  SER A N   1 
ATOM   105  C CA  . SER A 1 67  ? 101.055 103.958 95.390  1.00 98.96  ? 67  SER A CA  1 
ATOM   106  C C   . SER A 1 67  ? 101.260 104.073 96.897  1.00 91.93  ? 67  SER A C   1 
ATOM   107  O O   . SER A 1 67  ? 101.413 105.182 97.405  1.00 115.60 ? 67  SER A O   1 
ATOM   108  C CB  . SER A 1 67  ? 99.599  104.146 95.021  1.00 113.68 ? 67  SER A CB  1 
ATOM   109  O OG  . SER A 1 67  ? 99.449  104.190 93.601  1.00 125.63 ? 67  SER A OG  1 
ATOM   110  N N   . SER A 1 68  ? 101.184 102.953 97.620  1.00 97.13  ? 68  SER A N   1 
ATOM   111  C CA  . SER A 1 68  ? 101.431 102.928 99.061  1.00 89.26  ? 68  SER A CA  1 
ATOM   112  C C   . SER A 1 68  ? 102.787 102.293 99.342  1.00 79.21  ? 68  SER A C   1 
ATOM   113  O O   . SER A 1 68  ? 103.584 102.827 100.089 1.00 88.13  ? 68  SER A O   1 
ATOM   114  C CB  . SER A 1 68  ? 100.323 102.209 99.790  1.00 86.06  ? 68  SER A CB  1 
ATOM   115  O OG  . SER A 1 68  ? 100.605 102.153 101.168 1.00 94.39  ? 68  SER A OG  1 
ATOM   116  N N   . PHE A 1 69  ? 103.091 101.186 98.664  1.00 88.73  ? 69  PHE A N   1 
ATOM   117  C CA  . PHE A 1 69  ? 104.382 100.527 98.775  1.00 72.35  ? 69  PHE A CA  1 
ATOM   118  C C   . PHE A 1 69  ? 105.526 101.497 98.454  1.00 65.10  ? 69  PHE A C   1 
ATOM   119  O O   . PHE A 1 69  ? 106.535 101.477 99.140  1.00 70.63  ? 69  PHE A O   1 
ATOM   120  C CB  . PHE A 1 69  ? 104.360 99.279  97.882  1.00 75.59  ? 69  PHE A CB  1 
ATOM   121  C CG  . PHE A 1 69  ? 105.676 98.566  97.740  1.00 77.40  ? 69  PHE A CG  1 
ATOM   122  C CD1 . PHE A 1 69  ? 106.589 98.966  96.763  1.00 72.16  ? 69  PHE A CD1 1 
ATOM   123  C CD2 . PHE A 1 69  ? 105.996 97.511  98.584  1.00 84.50  ? 69  PHE A CD2 1 
ATOM   124  C CE1 . PHE A 1 69  ? 107.812 98.346  96.656  1.00 89.97  ? 69  PHE A CE1 1 
ATOM   125  C CE2 . PHE A 1 69  ? 107.210 96.857  98.444  1.00 94.93  ? 69  PHE A CE2 1 
ATOM   126  C CZ  . PHE A 1 69  ? 108.111 97.288  97.496  1.00 104.71 ? 69  PHE A CZ  1 
ATOM   127  N N   . LEU A 1 70  ? 105.382 102.367 97.453  1.00 67.79  ? 70  LEU A N   1 
ATOM   128  C CA  . LEU A 1 70  ? 106.455 103.299 97.132  1.00 66.20  ? 70  LEU A CA  1 
ATOM   129  C C   . LEU A 1 70  ? 106.502 104.477 98.105  1.00 81.11  ? 70  LEU A C   1 
ATOM   130  O O   . LEU A 1 70  ? 107.405 105.291 97.981  1.00 122.56 ? 70  LEU A O   1 
ATOM   131  C CB  . LEU A 1 70  ? 106.268 103.880 95.716  1.00 80.22  ? 70  LEU A CB  1 
ATOM   132  C CG  . LEU A 1 70  ? 106.534 102.941 94.560  1.00 84.12  ? 70  LEU A CG  1 
ATOM   133  C CD1 . LEU A 1 70  ? 106.381 103.658 93.242  1.00 83.93  ? 70  LEU A CD1 1 
ATOM   134  C CD2 . LEU A 1 70  ? 107.928 102.376 94.734  1.00 97.27  ? 70  LEU A CD2 1 
ATOM   135  N N   . TYR A 1 71  ? 105.580 104.615 99.067  1.00 70.81  ? 71  TYR A N   1 
ATOM   136  C CA  . TYR A 1 71  ? 105.826 105.499 100.197 1.00 66.65  ? 71  TYR A CA  1 
ATOM   137  C C   . TYR A 1 71  ? 106.677 104.741 101.208 1.00 55.28  ? 71  TYR A C   1 
ATOM   138  O O   . TYR A 1 71  ? 107.722 105.205 101.597 1.00 68.99  ? 71  TYR A O   1 
ATOM   139  C CB  . TYR A 1 71  ? 104.505 106.002 100.790 1.00 71.34  ? 71  TYR A CB  1 
ATOM   140  C CG  . TYR A 1 71  ? 104.627 106.740 102.116 1.00 64.06  ? 71  TYR A CG  1 
ATOM   141  C CD1 . TYR A 1 71  ? 105.203 107.995 102.178 1.00 67.45  ? 71  TYR A CD1 1 
ATOM   142  C CD2 . TYR A 1 71  ? 104.170 106.173 103.294 1.00 63.47  ? 71  TYR A CD2 1 
ATOM   143  C CE1 . TYR A 1 71  ? 105.308 108.674 103.377 1.00 89.09  ? 71  TYR A CE1 1 
ATOM   144  C CE2 . TYR A 1 71  ? 104.280 106.829 104.500 1.00 89.58  ? 71  TYR A CE2 1 
ATOM   145  C CZ  . TYR A 1 71  ? 104.843 108.098 104.545 1.00 102.29 ? 71  TYR A CZ  1 
ATOM   146  O OH  . TYR A 1 71  ? 104.944 108.786 105.733 1.00 81.66  ? 71  TYR A OH  1 
ATOM   147  N N   . GLY A 1 72  ? 106.242 103.550 101.592 1.00 54.36  ? 72  GLY A N   1 
ATOM   148  C CA  . GLY A 1 72  ? 106.942 102.706 102.547 1.00 49.90  ? 72  GLY A CA  1 
ATOM   149  C C   . GLY A 1 72  ? 108.377 102.397 102.127 1.00 52.72  ? 72  GLY A C   1 
ATOM   150  O O   . GLY A 1 72  ? 109.272 102.394 102.963 1.00 45.79  ? 72  GLY A O   1 
ATOM   151  N N   . TYR A 1 73  ? 108.617 102.160 100.835 1.00 48.79  ? 73  TYR A N   1 
ATOM   152  C CA  . TYR A 1 73  ? 109.957 101.946 100.318 1.00 50.54  ? 73  TYR A CA  1 
ATOM   153  C C   . TYR A 1 73  ? 110.796 103.218 100.403 1.00 49.40  ? 73  TYR A C   1 
ATOM   154  O O   . TYR A 1 73  ? 111.929 103.164 100.880 1.00 66.63  ? 73  TYR A O   1 
ATOM   155  C CB  . TYR A 1 73  ? 109.844 101.448 98.885  1.00 57.22  ? 73  TYR A CB  1 
ATOM   156  C CG  . TYR A 1 73  ? 111.158 101.065 98.223  1.00 55.47  ? 73  TYR A CG  1 
ATOM   157  C CD1 . TYR A 1 73  ? 111.696 99.793  98.387  1.00 66.79  ? 73  TYR A CD1 1 
ATOM   158  C CD2 . TYR A 1 73  ? 111.854 101.984 97.448  1.00 57.81  ? 73  TYR A CD2 1 
ATOM   159  C CE1 . TYR A 1 73  ? 112.879 99.432  97.764  1.00 76.48  ? 73  TYR A CE1 1 
ATOM   160  C CE2 . TYR A 1 73  ? 113.038 101.647 96.831  1.00 65.95  ? 73  TYR A CE2 1 
ATOM   161  C CZ  . TYR A 1 73  ? 113.549 100.362 96.983  1.00 78.33  ? 73  TYR A CZ  1 
ATOM   162  O OH  . TYR A 1 73  ? 114.725 100.003 96.382  1.00 69.09  ? 73  TYR A OH  1 
ATOM   163  N N   . ASN A 1 74  ? 110.249 104.361 99.988  1.00 46.53  ? 74  ASN A N   1 
ATOM   164  C CA  . ASN A 1 74  ? 111.005 105.598 99.927  1.00 53.67  ? 74  ASN A CA  1 
ATOM   165  C C   . ASN A 1 74  ? 111.394 106.153 101.304 1.00 48.53  ? 74  ASN A C   1 
ATOM   166  O O   . ASN A 1 74  ? 112.324 106.942 101.377 1.00 45.42  ? 74  ASN A O   1 
ATOM   167  C CB  . ASN A 1 74  ? 110.279 106.647 99.095  1.00 68.12  ? 74  ASN A CB  1 
ATOM   168  C CG  . ASN A 1 74  ? 110.617 106.501 97.627  1.00 82.19  ? 74  ASN A CG  1 
ATOM   169  O OD1 . ASN A 1 74  ? 111.781 106.632 97.252  1.00 88.14  ? 74  ASN A OD1 1 
ATOM   170  N ND2 . ASN A 1 74  ? 109.623 106.232 96.792  1.00 84.24  ? 74  ASN A ND2 1 
ATOM   171  N N   . LEU A 1 75  ? 110.764 105.724 102.396 1.00 48.33  ? 75  LEU A N   1 
ATOM   172  C CA  . LEU A 1 75  ? 111.188 106.164 103.714 1.00 56.27  ? 75  LEU A CA  1 
ATOM   173  C C   . LEU A 1 75  ? 112.111 105.152 104.397 1.00 48.18  ? 75  LEU A C   1 
ATOM   174  O O   . LEU A 1 75  ? 112.492 105.375 105.548 1.00 72.67  ? 75  LEU A O   1 
ATOM   175  C CB  . LEU A 1 75  ? 109.980 106.578 104.600 1.00 59.17  ? 75  LEU A CB  1 
ATOM   176  C CG  . LEU A 1 75  ? 108.972 105.525 104.999 1.00 67.39  ? 75  LEU A CG  1 
ATOM   177  C CD1 . LEU A 1 75  ? 109.343 104.848 106.286 1.00 83.63  ? 75  LEU A CD1 1 
ATOM   178  C CD2 . LEU A 1 75  ? 107.607 106.158 105.151 1.00 75.56  ? 75  LEU A CD2 1 
ATOM   179  N N   . SER A 1 76  ? 112.598 104.134 103.693 1.00 47.54  ? 76  SER A N   1 
ATOM   180  C CA  . SER A 1 76  ? 113.653 103.290 104.249 1.00 60.97  ? 76  SER A CA  1 
ATOM   181  C C   . SER A 1 76  ? 114.790 103.005 103.271 1.00 59.89  ? 76  SER A C   1 
ATOM   182  O O   . SER A 1 76  ? 115.869 102.600 103.714 1.00 73.23  ? 76  SER A O   1 
ATOM   183  C CB  . SER A 1 76  ? 113.104 101.973 104.811 1.00 64.76  ? 76  SER A CB  1 
ATOM   184  O OG  . SER A 1 76  ? 112.829 101.034 103.784 1.00 51.15  ? 76  SER A OG  1 
ATOM   185  N N   . VAL A 1 77  ? 114.580 103.209 101.963 1.00 60.91  ? 77  VAL A N   1 
ATOM   186  C CA  . VAL A 1 77  ? 115.630 102.978 100.971 1.00 67.97  ? 77  VAL A CA  1 
ATOM   187  C C   . VAL A 1 77  ? 116.838 103.878 101.230 1.00 75.61  ? 77  VAL A C   1 
ATOM   188  O O   . VAL A 1 77  ? 117.953 103.534 100.857 1.00 75.76  ? 77  VAL A O   1 
ATOM   189  C CB  . VAL A 1 77  ? 115.115 103.180 99.536  1.00 72.42  ? 77  VAL A CB  1 
ATOM   190  C CG1 . VAL A 1 77  ? 114.817 104.646 99.250  1.00 74.44  ? 77  VAL A CG1 1 
ATOM   191  C CG2 . VAL A 1 77  ? 116.086 102.605 98.518  1.00 85.43  ? 77  VAL A CG2 1 
ATOM   192  N N   . VAL A 1 78  ? 116.599 105.037 101.862 1.00 89.29  ? 78  VAL A N   1 
ATOM   193  C CA  . VAL A 1 78  ? 117.606 106.074 102.080 1.00 70.48  ? 78  VAL A CA  1 
ATOM   194  C C   . VAL A 1 78  ? 118.533 105.713 103.251 1.00 63.68  ? 78  VAL A C   1 
ATOM   195  O O   . VAL A 1 78  ? 119.558 106.342 103.417 1.00 58.82  ? 78  VAL A O   1 
ATOM   196  C CB  . VAL A 1 78  ? 116.881 107.422 102.311 1.00 69.49  ? 78  VAL A CB  1 
ATOM   197  C CG1 . VAL A 1 78  ? 116.312 107.567 103.733 1.00 67.05  ? 78  VAL A CG1 1 
ATOM   198  C CG2 . VAL A 1 78  ? 117.778 108.595 101.996 1.00 92.10  ? 78  VAL A CG2 1 
ATOM   199  N N   . ASN A 1 79  ? 118.193 104.693 104.058 1.00 79.00  ? 79  ASN A N   1 
ATOM   200  C CA  . ASN A 1 79  ? 119.013 104.258 105.181 1.00 70.24  ? 79  ASN A CA  1 
ATOM   201  C C   . ASN A 1 79  ? 120.324 103.610 104.726 1.00 72.41  ? 79  ASN A C   1 
ATOM   202  O O   . ASN A 1 79  ? 121.401 104.109 105.026 1.00 71.32  ? 79  ASN A O   1 
ATOM   203  C CB  . ASN A 1 79  ? 118.256 103.273 106.066 1.00 75.23  ? 79  ASN A CB  1 
ATOM   204  C CG  . ASN A 1 79  ? 119.165 102.606 107.073 1.00 71.45  ? 79  ASN A CG  1 
ATOM   205  O OD1 . ASN A 1 79  ? 119.814 103.263 107.884 1.00 67.22  ? 79  ASN A OD1 1 
ATOM   206  N ND2 . ASN A 1 79  ? 119.228 101.297 107.007 1.00 90.19  ? 79  ASN A ND2 1 
ATOM   207  N N   . ALA A 1 80  ? 120.232 102.509 103.969 1.00 94.75  ? 80  ALA A N   1 
ATOM   208  C CA  . ALA A 1 80  ? 121.366 101.632 103.684 1.00 97.94  ? 80  ALA A CA  1 
ATOM   209  C C   . ALA A 1 80  ? 122.507 102.322 102.931 1.00 74.81  ? 80  ALA A C   1 
ATOM   210  O O   . ALA A 1 80  ? 123.659 102.071 103.269 1.00 84.29  ? 80  ALA A O   1 
ATOM   211  C CB  . ALA A 1 80  ? 120.852 100.404 102.940 1.00 137.58 ? 80  ALA A CB  1 
ATOM   212  N N   . PRO A 1 81  ? 122.292 103.140 101.867 1.00 70.17  ? 81  PRO A N   1 
ATOM   213  C CA  . PRO A 1 81  ? 123.379 103.814 101.175 1.00 75.60  ? 81  PRO A CA  1 
ATOM   214  C C   . PRO A 1 81  ? 123.880 105.104 101.826 1.00 67.46  ? 81  PRO A C   1 
ATOM   215  O O   . PRO A 1 81  ? 124.658 105.818 101.219 1.00 80.73  ? 81  PRO A O   1 
ATOM   216  C CB  . PRO A 1 81  ? 122.760 104.107 99.799  1.00 82.40  ? 81  PRO A CB  1 
ATOM   217  C CG  . PRO A 1 81  ? 121.340 104.398 100.099 1.00 87.49  ? 81  PRO A CG  1 
ATOM   218  C CD  . PRO A 1 81  ? 121.014 103.435 101.222 1.00 85.32  ? 81  PRO A CD  1 
ATOM   219  N N   . THR A 1 82  ? 123.541 105.365 103.095 1.00 73.12  ? 82  THR A N   1 
ATOM   220  C CA  . THR A 1 82  ? 123.963 106.590 103.790 1.00 74.49  ? 82  THR A CA  1 
ATOM   221  C C   . THR A 1 82  ? 125.471 106.830 103.681 1.00 67.49  ? 82  THR A C   1 
ATOM   222  O O   . THR A 1 82  ? 125.861 107.953 103.388 1.00 75.83  ? 82  THR A O   1 
ATOM   223  C CB  . THR A 1 82  ? 123.562 106.576 105.271 1.00 97.11  ? 82  THR A CB  1 
ATOM   224  O OG1 . THR A 1 82  ? 122.148 106.689 105.373 1.00 105.39 ? 82  THR A OG1 1 
ATOM   225  C CG2 . THR A 1 82  ? 124.178 107.693 106.080 1.00 112.42 ? 82  THR A CG2 1 
ATOM   226  N N   . PRO A 1 83  ? 126.384 105.857 103.944 1.00 64.79  ? 83  PRO A N   1 
ATOM   227  C CA  . PRO A 1 83  ? 127.814 106.130 103.911 1.00 76.64  ? 83  PRO A CA  1 
ATOM   228  C C   . PRO A 1 83  ? 128.417 106.270 102.522 1.00 84.52  ? 83  PRO A C   1 
ATOM   229  O O   . PRO A 1 83  ? 129.549 106.740 102.408 1.00 99.17  ? 83  PRO A O   1 
ATOM   230  C CB  . PRO A 1 83  ? 128.414 104.915 104.631 1.00 108.21 ? 83  PRO A CB  1 
ATOM   231  C CG  . PRO A 1 83  ? 127.443 103.784 104.308 1.00 102.88 ? 83  PRO A CG  1 
ATOM   232  C CD  . PRO A 1 83  ? 126.103 104.479 104.355 1.00 85.63  ? 83  PRO A CD  1 
ATOM   233  N N   . TYR A 1 84  ? 127.676 105.847 101.470 1.00 87.25  ? 84  TYR A N   1 
ATOM   234  C CA  . TYR A 1 84  ? 128.102 105.948 100.080 1.00 90.85  ? 84  TYR A CA  1 
ATOM   235  C C   . TYR A 1 84  ? 127.614 107.259 99.459  1.00 74.63  ? 84  TYR A C   1 
ATOM   236  O O   . TYR A 1 84  ? 128.341 107.875 98.685  1.00 69.55  ? 84  TYR A O   1 
ATOM   237  C CB  . TYR A 1 84  ? 127.654 104.720 99.297  1.00 72.78  ? 84  TYR A CB  1 
ATOM   238  C CG  . TYR A 1 84  ? 128.164 103.422 99.899  1.00 99.72  ? 84  TYR A CG  1 
ATOM   239  C CD1 . TYR A 1 84  ? 129.518 103.255 100.198 1.00 112.76 ? 84  TYR A CD1 1 
ATOM   240  C CD2 . TYR A 1 84  ? 127.303 102.365 100.184 1.00 120.22 ? 84  TYR A CD2 1 
ATOM   241  C CE1 . TYR A 1 84  ? 129.997 102.083 100.765 1.00 131.48 ? 84  TYR A CE1 1 
ATOM   242  C CE2 . TYR A 1 84  ? 127.774 101.187 100.752 1.00 136.41 ? 84  TYR A CE2 1 
ATOM   243  C CZ  . TYR A 1 84  ? 129.122 101.043 101.042 1.00 140.73 ? 84  TYR A CZ  1 
ATOM   244  O OH  . TYR A 1 84  ? 129.583 99.874  101.585 1.00 145.55 ? 84  TYR A OH  1 
ATOM   245  N N   . ILE A 1 85  ? 126.407 107.707 99.817  1.00 60.17  ? 85  ILE A N   1 
ATOM   246  C CA  . ILE A 1 85  ? 125.911 108.975 99.321  1.00 68.48  ? 85  ILE A CA  1 
ATOM   247  C C   . ILE A 1 85  ? 126.691 110.122 99.969  1.00 85.75  ? 85  ILE A C   1 
ATOM   248  O O   . ILE A 1 85  ? 127.123 111.023 99.260  1.00 105.77 ? 85  ILE A O   1 
ATOM   249  C CB  . ILE A 1 85  ? 124.394 109.133 99.532  1.00 78.66  ? 85  ILE A CB  1 
ATOM   250  C CG1 . ILE A 1 85  ? 123.616 108.039 98.805  1.00 76.32  ? 85  ILE A CG1 1 
ATOM   251  C CG2 . ILE A 1 85  ? 123.950 110.512 99.091  1.00 83.23  ? 85  ILE A CG2 1 
ATOM   252  C CD1 . ILE A 1 85  ? 122.206 107.830 99.301  1.00 83.79  ? 85  ILE A CD1 1 
ATOM   253  N N   . LYS A 1 86  ? 126.833 110.151 101.294 1.00 84.30  ? 86  LYS A N   1 
ATOM   254  C CA  . LYS A 1 86  ? 127.499 111.289 101.922 1.00 83.11  ? 86  LYS A CA  1 
ATOM   255  C C   . LYS A 1 86  ? 128.880 111.444 101.311 1.00 100.03 ? 86  LYS A C   1 
ATOM   256  O O   . LYS A 1 86  ? 129.378 112.573 101.255 1.00 146.60 ? 86  LYS A O   1 
ATOM   257  C CB  . LYS A 1 86  ? 127.569 111.199 103.461 1.00 70.97  ? 86  LYS A CB  1 
ATOM   258  C CG  . LYS A 1 86  ? 126.290 111.640 104.175 1.00 80.60  ? 86  LYS A CG  1 
ATOM   259  C CD  . LYS A 1 86  ? 126.062 110.953 105.477 1.00 77.42  ? 86  LYS A CD  1 
ATOM   260  C CE  . LYS A 1 86  ? 126.489 111.828 106.634 1.00 77.84  ? 86  LYS A CE  1 
ATOM   261  N NZ  . LYS A 1 86  ? 125.494 111.743 107.735 1.00 87.02  ? 86  LYS A NZ  1 
ATOM   262  N N   . ALA A 1 87  ? 129.481 110.342 100.833 1.00 86.79  ? 87  ALA A N   1 
ATOM   263  C CA  . ALA A 1 87  ? 130.819 110.386 100.251 1.00 94.89  ? 87  ALA A CA  1 
ATOM   264  C C   . ALA A 1 87  ? 130.783 111.053 98.877  1.00 90.87  ? 87  ALA A C   1 
ATOM   265  O O   . ALA A 1 87  ? 131.697 111.805 98.541  1.00 92.08  ? 87  ALA A O   1 
ATOM   266  C CB  . ALA A 1 87  ? 131.419 109.016 100.189 1.00 107.09 ? 87  ALA A CB  1 
ATOM   267  N N   . PHE A 1 88  ? 129.736 110.791 98.085  1.00 90.46  ? 88  PHE A N   1 
ATOM   268  C CA  . PHE A 1 88  ? 129.571 111.434 96.784  1.00 87.81  ? 88  PHE A CA  1 
ATOM   269  C C   . PHE A 1 88  ? 129.332 112.938 96.964  1.00 87.85  ? 88  PHE A C   1 
ATOM   270  O O   . PHE A 1 88  ? 129.778 113.725 96.131  1.00 103.34 ? 88  PHE A O   1 
ATOM   271  C CB  . PHE A 1 88  ? 128.498 110.726 95.943  1.00 73.65  ? 88  PHE A CB  1 
ATOM   272  C CG  . PHE A 1 88  ? 127.721 111.535 94.941  1.00 66.56  ? 88  PHE A CG  1 
ATOM   273  C CD1 . PHE A 1 88  ? 128.325 112.074 93.819  1.00 77.58  ? 88  PHE A CD1 1 
ATOM   274  C CD2 . PHE A 1 88  ? 126.354 111.737 95.116  1.00 78.87  ? 88  PHE A CD2 1 
ATOM   275  C CE1 . PHE A 1 88  ? 127.587 112.834 92.908  1.00 96.30  ? 88  PHE A CE1 1 
ATOM   276  C CE2 . PHE A 1 88  ? 125.608 112.480 94.206  1.00 81.39  ? 88  PHE A CE2 1 
ATOM   277  C CZ  . PHE A 1 88  ? 126.232 113.046 93.110  1.00 88.66  ? 88  PHE A CZ  1 
ATOM   278  N N   . TYR A 1 89  ? 128.662 113.359 98.045  1.00 67.83  ? 89  TYR A N   1 
ATOM   279  C CA  . TYR A 1 89  ? 128.501 114.786 98.273  1.00 79.77  ? 89  TYR A CA  1 
ATOM   280  C C   . TYR A 1 89  ? 129.878 115.406 98.474  1.00 80.63  ? 89  TYR A C   1 
ATOM   281  O O   . TYR A 1 89  ? 130.195 116.402 97.833  1.00 90.24  ? 89  TYR A O   1 
ATOM   282  C CB  . TYR A 1 89  ? 127.562 115.111 99.431  1.00 81.21  ? 89  TYR A CB  1 
ATOM   283  C CG  . TYR A 1 89  ? 126.094 114.820 99.173  1.00 87.12  ? 89  TYR A CG  1 
ATOM   284  C CD1 . TYR A 1 89  ? 125.648 114.331 97.957  1.00 78.75  ? 89  TYR A CD1 1 
ATOM   285  C CD2 . TYR A 1 89  ? 125.147 115.034 100.171 1.00 84.97  ? 89  TYR A CD2 1 
ATOM   286  C CE1 . TYR A 1 89  ? 124.309 114.040 97.737  1.00 66.18  ? 89  TYR A CE1 1 
ATOM   287  C CE2 . TYR A 1 89  ? 123.806 114.740 99.978  1.00 71.70  ? 89  TYR A CE2 1 
ATOM   288  C CZ  . TYR A 1 89  ? 123.395 114.221 98.762  1.00 62.37  ? 89  TYR A CZ  1 
ATOM   289  O OH  . TYR A 1 89  ? 122.084 113.937 98.564  1.00 83.61  ? 89  TYR A OH  1 
ATOM   290  N N   . ASN A 1 90  ? 130.700 114.788 99.330  1.00 70.54  ? 90  ASN A N   1 
ATOM   291  C CA  . ASN A 1 90  ? 132.044 115.269 99.610  1.00 78.22  ? 90  ASN A CA  1 
ATOM   292  C C   . ASN A 1 90  ? 132.780 115.547 98.301  1.00 88.79  ? 90  ASN A C   1 
ATOM   293  O O   . ASN A 1 90  ? 133.247 116.670 98.089  1.00 91.72  ? 90  ASN A O   1 
ATOM   294  C CB  . ASN A 1 90  ? 132.794 114.301 100.520 1.00 77.63  ? 90  ASN A CB  1 
ATOM   295  C CG  . ASN A 1 90  ? 134.171 114.765 100.930 1.00 87.87  ? 90  ASN A CG  1 
ATOM   296  O OD1 . ASN A 1 90  ? 134.631 115.834 100.530 1.00 107.67 ? 90  ASN A OD1 1 
ATOM   297  N ND2 . ASN A 1 90  ? 134.831 113.956 101.741 1.00 118.84 ? 90  ASN A ND2 1 
ATOM   298  N N   . GLU A 1 91  ? 132.865 114.548 97.410  1.00 91.48  ? 91  GLU A N   1 
ATOM   299  C CA  . GLU A 1 91  ? 133.617 114.705 96.175  1.00 96.38  ? 91  GLU A CA  1 
ATOM   300  C C   . GLU A 1 91  ? 132.930 115.729 95.271  1.00 99.59  ? 91  GLU A C   1 
ATOM   301  O O   . GLU A 1 91  ? 133.614 116.581 94.696  1.00 131.66 ? 91  GLU A O   1 
ATOM   302  C CB  . GLU A 1 91  ? 133.805 113.362 95.471  1.00 116.49 ? 91  GLU A CB  1 
ATOM   303  C CG  . GLU A 1 91  ? 134.568 112.346 96.294  1.00 165.51 ? 91  GLU A CG  1 
ATOM   304  C CD  . GLU A 1 91  ? 133.952 110.951 96.310  1.00 229.93 ? 91  GLU A CD  1 
ATOM   305  O OE1 . GLU A 1 91  ? 133.417 110.511 95.265  1.00 257.11 ? 91  GLU A OE1 1 
ATOM   306  O OE2 . GLU A 1 91  ? 134.029 110.284 97.367  1.00 256.30 ? 91  GLU A OE2 1 
ATOM   307  N N   . SER A 1 92  ? 131.598 115.648 95.128  1.00 100.05 ? 92  SER A N   1 
ATOM   308  C CA  . SER A 1 92  ? 130.861 116.535 94.235  1.00 103.12 ? 92  SER A CA  1 
ATOM   309  C C   . SER A 1 92  ? 130.834 117.976 94.748  1.00 110.58 ? 92  SER A C   1 
ATOM   310  O O   . SER A 1 92  ? 130.306 118.844 94.055  1.00 140.76 ? 92  SER A O   1 
ATOM   311  C CB  . SER A 1 92  ? 129.460 116.028 93.983  1.00 94.92  ? 92  SER A CB  1 
ATOM   312  O OG  . SER A 1 92  ? 128.765 116.899 93.102  1.00 108.36 ? 92  SER A OG  1 
ATOM   313  N N   . TRP A 1 93  ? 131.339 118.221 95.965  1.00 104.65 ? 93  TRP A N   1 
ATOM   314  C CA  . TRP A 1 93  ? 131.451 119.570 96.509  1.00 102.08 ? 93  TRP A CA  1 
ATOM   315  C C   . TRP A 1 93  ? 132.888 120.064 96.364  1.00 113.93 ? 93  TRP A C   1 
ATOM   316  O O   . TRP A 1 93  ? 133.147 121.254 96.525  1.00 150.02 ? 93  TRP A O   1 
ATOM   317  C CB  . TRP A 1 93  ? 130.997 119.598 97.976  1.00 104.26 ? 93  TRP A CB  1 
ATOM   318  C CG  . TRP A 1 93  ? 130.915 120.964 98.603  1.00 106.37 ? 93  TRP A CG  1 
ATOM   319  C CD1 . TRP A 1 93  ? 131.938 121.727 99.088  1.00 105.41 ? 93  TRP A CD1 1 
ATOM   320  C CD2 . TRP A 1 93  ? 129.711 121.721 98.841  1.00 120.32 ? 93  TRP A CD2 1 
ATOM   321  N NE1 . TRP A 1 93  ? 131.464 122.899 99.608  1.00 99.54  ? 93  TRP A NE1 1 
ATOM   322  C CE2 . TRP A 1 93  ? 130.104 122.926 99.472  1.00 127.25 ? 93  TRP A CE2 1 
ATOM   323  C CE3 . TRP A 1 93  ? 128.351 121.498 98.586  1.00 113.16 ? 93  TRP A CE3 1 
ATOM   324  C CZ2 . TRP A 1 93  ? 129.180 123.902 99.844  1.00 150.96 ? 93  TRP A CZ2 1 
ATOM   325  C CZ3 . TRP A 1 93  ? 127.440 122.457 98.966  1.00 124.92 ? 93  TRP A CZ3 1 
ATOM   326  C CH2 . TRP A 1 93  ? 127.853 123.652 99.564  1.00 151.91 ? 93  TRP A CH2 1 
ATOM   327  N N   . GLU A 1 94  ? 133.818 119.155 96.046  1.00 110.70 ? 94  GLU A N   1 
ATOM   328  C CA  . GLU A 1 94  ? 135.198 119.532 95.794  1.00 137.54 ? 94  GLU A CA  1 
ATOM   329  C C   . GLU A 1 94  ? 135.405 119.856 94.314  1.00 153.62 ? 94  GLU A C   1 
ATOM   330  O O   . GLU A 1 94  ? 136.076 120.836 93.999  1.00 179.25 ? 94  GLU A O   1 
ATOM   331  C CB  . GLU A 1 94  ? 136.159 118.438 96.261  1.00 175.53 ? 94  GLU A CB  1 
ATOM   332  C CG  . GLU A 1 94  ? 136.226 118.305 97.777  1.00 223.82 ? 94  GLU A CG  1 
ATOM   333  C CD  . GLU A 1 94  ? 137.597 117.917 98.308  1.00 264.10 ? 94  GLU A CD  1 
ATOM   334  O OE1 . GLU A 1 94  ? 138.604 118.217 97.628  1.00 261.86 ? 94  GLU A OE1 1 
ATOM   335  O OE2 . GLU A 1 94  ? 137.653 117.281 99.384  1.00 283.49 ? 94  GLU A OE2 1 
ATOM   336  N N   . ARG A 1 95  ? 134.805 119.067 93.411  1.00 177.53 ? 95  ARG A N   1 
ATOM   337  C CA  . ARG A 1 95  ? 135.018 119.249 91.978  1.00 200.06 ? 95  ARG A CA  1 
ATOM   338  C C   . ARG A 1 95  ? 134.107 120.336 91.388  1.00 194.89 ? 95  ARG A C   1 
ATOM   339  O O   . ARG A 1 95  ? 134.064 120.475 90.163  1.00 211.90 ? 95  ARG A O   1 
ATOM   340  C CB  . ARG A 1 95  ? 134.863 117.926 91.208  1.00 205.44 ? 95  ARG A CB  1 
ATOM   341  C CG  . ARG A 1 95  ? 133.454 117.350 91.160  1.00 205.84 ? 95  ARG A CG  1 
ATOM   342  C CD  . ARG A 1 95  ? 133.335 116.096 90.314  1.00 218.72 ? 95  ARG A CD  1 
ATOM   343  N NE  . ARG A 1 95  ? 133.411 116.380 88.886  1.00 272.00 ? 95  ARG A NE  1 
ATOM   344  C CZ  . ARG A 1 95  ? 133.201 115.485 87.918  1.00 317.93 ? 95  ARG A CZ  1 
ATOM   345  N NH1 . ARG A 1 95  ? 133.230 115.858 86.650  1.00 321.67 ? 95  ARG A NH1 1 
ATOM   346  N NH2 . ARG A 1 95  ? 132.948 114.224 88.224  1.00 326.66 ? 95  ARG A NH2 1 
ATOM   347  N N   . ARG A 1 96  ? 133.412 121.126 92.239  1.00 164.16 ? 96  ARG A N   1 
ATOM   348  C CA  . ARG A 1 96  ? 132.602 122.251 91.785  1.00 176.04 ? 96  ARG A CA  1 
ATOM   349  C C   . ARG A 1 96  ? 132.916 123.530 92.570  1.00 177.36 ? 96  ARG A C   1 
ATOM   350  O O   . ARG A 1 96  ? 133.002 124.604 91.974  1.00 215.88 ? 96  ARG A O   1 
ATOM   351  C CB  . ARG A 1 96  ? 131.100 121.940 91.860  1.00 177.96 ? 96  ARG A CB  1 
ATOM   352  C CG  . ARG A 1 96  ? 130.651 120.854 90.889  1.00 216.91 ? 96  ARG A CG  1 
ATOM   353  C CD  . ARG A 1 96  ? 129.164 120.897 90.585  1.00 197.52 ? 96  ARG A CD  1 
ATOM   354  N NE  . ARG A 1 96  ? 128.354 120.782 91.788  1.00 162.65 ? 96  ARG A NE  1 
ATOM   355  C CZ  . ARG A 1 96  ? 127.032 120.868 91.835  1.00 132.37 ? 96  ARG A CZ  1 
ATOM   356  N NH1 . ARG A 1 96  ? 126.420 120.854 93.000  1.00 140.42 ? 96  ARG A NH1 1 
ATOM   357  N NH2 . ARG A 1 96  ? 126.325 121.033 90.735  1.00 155.18 ? 96  ARG A NH2 1 
ATOM   358  N N   . HIS A 1 97  ? 133.086 123.431 93.893  1.00 169.47 ? 97  HIS A N   1 
ATOM   359  C CA  . HIS A 1 97  ? 133.254 124.604 94.745  1.00 182.88 ? 97  HIS A CA  1 
ATOM   360  C C   . HIS A 1 97  ? 134.713 124.818 95.171  1.00 193.12 ? 97  HIS A C   1 
ATOM   361  O O   . HIS A 1 97  ? 135.024 125.853 95.762  1.00 212.49 ? 97  HIS A O   1 
ATOM   362  C CB  . HIS A 1 97  ? 132.280 124.549 95.932  1.00 185.26 ? 97  HIS A CB  1 
ATOM   363  C CG  . HIS A 1 97  ? 130.844 124.713 95.560  1.00 220.37 ? 97  HIS A CG  1 
ATOM   364  N ND1 . HIS A 1 97  ? 130.145 123.874 94.721  1.00 246.24 ? 97  HIS A ND1 1 
ATOM   365  C CD2 . HIS A 1 97  ? 129.974 125.657 95.938  1.00 256.46 ? 97  HIS A CD2 1 
ATOM   366  C CE1 . HIS A 1 97  ? 128.896 124.306 94.602  1.00 268.34 ? 97  HIS A CE1 1 
ATOM   367  N NE2 . HIS A 1 97  ? 128.767 125.390 95.334  1.00 265.17 ? 97  HIS A NE2 1 
ATOM   368  N N   . GLY A 1 98  ? 135.612 123.861 94.892  1.00 211.98 ? 98  GLY A N   1 
ATOM   369  C CA  . GLY A 1 98  ? 137.050 124.102 94.964  1.00 240.36 ? 98  GLY A CA  1 
ATOM   370  C C   . GLY A 1 98  ? 137.665 123.982 96.363  1.00 238.78 ? 98  GLY A C   1 
ATOM   371  O O   . GLY A 1 98  ? 138.831 124.334 96.539  1.00 238.00 ? 98  GLY A O   1 
ATOM   372  N N   . ARG A 1 99  ? 136.899 123.487 97.352  1.00 222.00 ? 99  ARG A N   1 
ATOM   373  C CA  . ARG A 1 99  ? 137.414 123.230 98.696  1.00 206.26 ? 99  ARG A CA  1 
ATOM   374  C C   . ARG A 1 99  ? 136.665 122.052 99.331  1.00 190.45 ? 99  ARG A C   1 
ATOM   375  O O   . ARG A 1 99  ? 135.527 121.765 98.958  1.00 205.14 ? 99  ARG A O   1 
ATOM   376  C CB  . ARG A 1 99  ? 137.362 124.489 99.579  1.00 205.91 ? 99  ARG A CB  1 
ATOM   377  C CG  . ARG A 1 99  ? 135.979 124.997 99.974  1.00 236.12 ? 99  ARG A CG  1 
ATOM   378  C CD  . ARG A 1 99  ? 135.215 125.660 98.842  1.00 268.71 ? 99  ARG A CD  1 
ATOM   379  N NE  . ARG A 1 99  ? 134.085 126.445 99.335  1.00 279.44 ? 99  ARG A NE  1 
ATOM   380  C CZ  . ARG A 1 99  ? 133.445 127.396 98.654  1.00 262.77 ? 99  ARG A CZ  1 
ATOM   381  N NH1 . ARG A 1 99  ? 132.398 128.000 99.187  1.00 281.47 ? 99  ARG A NH1 1 
ATOM   382  N NH2 . ARG A 1 99  ? 133.826 127.728 97.432  1.00 224.68 ? 99  ARG A NH2 1 
ATOM   383  N N   . PRO A 1 100 ? 137.278 121.316 100.293 1.00 192.20 ? 100 PRO A N   1 
ATOM   384  C CA  . PRO A 1 100 ? 136.600 120.220 100.990 1.00 199.53 ? 100 PRO A CA  1 
ATOM   385  C C   . PRO A 1 100 ? 135.362 120.673 101.758 1.00 162.63 ? 100 PRO A C   1 
ATOM   386  O O   . PRO A 1 100 ? 135.333 121.788 102.277 1.00 162.55 ? 100 PRO A O   1 
ATOM   387  C CB  . PRO A 1 100 ? 137.650 119.687 101.979 1.00 227.26 ? 100 PRO A CB  1 
ATOM   388  C CG  . PRO A 1 100 ? 138.974 120.162 101.415 1.00 239.50 ? 100 PRO A CG  1 
ATOM   389  C CD  . PRO A 1 100 ? 138.661 121.492 100.759 1.00 208.37 ? 100 PRO A CD  1 
ATOM   390  N N   . ILE A 1 101 ? 134.355 119.787 101.843 1.00 127.33 ? 101 ILE A N   1 
ATOM   391  C CA  . ILE A 1 101 ? 133.113 120.103 102.541 1.00 107.04 ? 101 ILE A CA  1 
ATOM   392  C C   . ILE A 1 101 ? 133.334 119.938 104.044 1.00 114.24 ? 101 ILE A C   1 
ATOM   393  O O   . ILE A 1 101 ? 133.947 118.969 104.478 1.00 112.71 ? 101 ILE A O   1 
ATOM   394  C CB  . ILE A 1 101 ? 131.932 119.245 102.034 1.00 94.51  ? 101 ILE A CB  1 
ATOM   395  C CG1 . ILE A 1 101 ? 130.595 119.705 102.608 1.00 78.44  ? 101 ILE A CG1 1 
ATOM   396  C CG2 . ILE A 1 101 ? 132.151 117.765 102.301 1.00 121.20 ? 101 ILE A CG2 1 
ATOM   397  C CD1 . ILE A 1 101 ? 129.394 119.232 101.828 1.00 77.99  ? 101 ILE A CD1 1 
ATOM   398  N N   . ASP A 1 102 ? 132.824 120.901 104.825 1.00 144.84 ? 102 ASP A N   1 
ATOM   399  C CA  . ASP A 1 102 ? 132.929 120.895 106.277 1.00 160.84 ? 102 ASP A CA  1 
ATOM   400  C C   . ASP A 1 102 ? 131.887 119.938 106.864 1.00 148.47 ? 102 ASP A C   1 
ATOM   401  O O   . ASP A 1 102 ? 130.788 119.804 106.317 1.00 168.27 ? 102 ASP A O   1 
ATOM   402  C CB  . ASP A 1 102 ? 132.758 122.310 106.833 1.00 187.33 ? 102 ASP A CB  1 
ATOM   403  C CG  . ASP A 1 102 ? 131.528 123.018 106.301 1.00 208.55 ? 102 ASP A CG  1 
ATOM   404  O OD1 . ASP A 1 102 ? 131.617 123.598 105.192 1.00 195.30 ? 102 ASP A OD1 1 
ATOM   405  O OD2 . ASP A 1 102 ? 130.477 122.943 106.975 1.00 212.53 ? 102 ASP A OD2 1 
ATOM   406  N N   . PRO A 1 103 ? 132.176 119.254 108.002 1.00 112.25 ? 103 PRO A N   1 
ATOM   407  C CA  . PRO A 1 103 ? 131.271 118.246 108.562 1.00 107.68 ? 103 PRO A CA  1 
ATOM   408  C C   . PRO A 1 103 ? 129.824 118.671 108.841 1.00 117.39 ? 103 PRO A C   1 
ATOM   409  O O   . PRO A 1 103 ? 128.919 117.839 108.738 1.00 121.24 ? 103 PRO A O   1 
ATOM   410  C CB  . PRO A 1 103 ? 131.945 117.851 109.883 1.00 127.89 ? 103 PRO A CB  1 
ATOM   411  C CG  . PRO A 1 103 ? 133.406 118.173 109.669 1.00 137.89 ? 103 PRO A CG  1 
ATOM   412  C CD  . PRO A 1 103 ? 133.409 119.394 108.787 1.00 115.44 ? 103 PRO A CD  1 
ATOM   413  N N   . ASP A 1 104 ? 129.608 119.958 109.159 1.00 122.92 ? 104 ASP A N   1 
ATOM   414  C CA  . ASP A 1 104 ? 128.274 120.476 109.424 1.00 123.17 ? 104 ASP A CA  1 
ATOM   415  C C   . ASP A 1 104 ? 127.503 120.646 108.114 1.00 90.93  ? 104 ASP A C   1 
ATOM   416  O O   . ASP A 1 104 ? 126.341 120.251 108.048 1.00 89.76  ? 104 ASP A O   1 
ATOM   417  C CB  . ASP A 1 104 ? 128.315 121.778 110.235 1.00 160.26 ? 104 ASP A CB  1 
ATOM   418  C CG  . ASP A 1 104 ? 128.837 121.603 111.649 1.00 196.33 ? 104 ASP A CG  1 
ATOM   419  O OD1 . ASP A 1 104 ? 128.466 120.588 112.272 1.00 231.42 ? 104 ASP A OD1 1 
ATOM   420  O OD2 . ASP A 1 104 ? 129.589 122.493 112.121 1.00 203.84 ? 104 ASP A OD2 1 
ATOM   421  N N   . THR A 1 105 ? 128.129 121.222 107.072 1.00 68.98  ? 105 THR A N   1 
ATOM   422  C CA  . THR A 1 105 ? 127.458 121.361 105.793 1.00 76.63  ? 105 THR A CA  1 
ATOM   423  C C   . THR A 1 105 ? 127.103 119.987 105.228 1.00 81.95  ? 105 THR A C   1 
ATOM   424  O O   . THR A 1 105 ? 126.031 119.820 104.649 1.00 76.47  ? 105 THR A O   1 
ATOM   425  C CB  . THR A 1 105 ? 128.267 122.186 104.783 1.00 92.67  ? 105 THR A CB  1 
ATOM   426  O OG1 . THR A 1 105 ? 128.563 123.445 105.382 1.00 117.21 ? 105 THR A OG1 1 
ATOM   427  C CG2 . THR A 1 105 ? 127.533 122.432 103.481 1.00 105.65 ? 105 THR A CG2 1 
ATOM   428  N N   . LEU A 1 106 ? 127.992 119.001 105.401 1.00 90.92  ? 106 LEU A N   1 
ATOM   429  C CA  . LEU A 1 106 ? 127.744 117.637 104.950 1.00 77.12  ? 106 LEU A CA  1 
ATOM   430  C C   . LEU A 1 106 ? 126.593 116.991 105.729 1.00 86.50  ? 106 LEU A C   1 
ATOM   431  O O   . LEU A 1 106 ? 125.731 116.342 105.125 1.00 84.51  ? 106 LEU A O   1 
ATOM   432  C CB  . LEU A 1 106 ? 129.033 116.831 105.090 1.00 65.98  ? 106 LEU A CB  1 
ATOM   433  C CG  . LEU A 1 106 ? 128.934 115.376 104.664 1.00 73.18  ? 106 LEU A CG  1 
ATOM   434  C CD1 . LEU A 1 106 ? 128.445 115.247 103.242 1.00 69.30  ? 106 LEU A CD1 1 
ATOM   435  C CD2 . LEU A 1 106 ? 130.281 114.679 104.767 1.00 87.12  ? 106 LEU A CD2 1 
ATOM   436  N N   . THR A 1 107 ? 126.547 117.188 107.054 1.00 88.19  ? 107 THR A N   1 
ATOM   437  C CA  . THR A 1 107 ? 125.436 116.690 107.859 1.00 102.52 ? 107 THR A CA  1 
ATOM   438  C C   . THR A 1 107 ? 124.119 117.367 107.470 1.00 93.19  ? 107 THR A C   1 
ATOM   439  O O   . THR A 1 107 ? 123.077 116.713 107.463 1.00 92.19  ? 107 THR A O   1 
ATOM   440  C CB  . THR A 1 107 ? 125.704 116.813 109.364 1.00 109.44 ? 107 THR A CB  1 
ATOM   441  O OG1 . THR A 1 107 ? 126.906 116.104 109.675 1.00 124.12 ? 107 THR A OG1 1 
ATOM   442  C CG2 . THR A 1 107 ? 124.588 116.234 110.203 1.00 106.82 ? 107 THR A CG2 1 
ATOM   443  N N   . LEU A 1 108 ? 124.167 118.655 107.109 1.00 94.94  ? 108 LEU A N   1 
ATOM   444  C CA  . LEU A 1 108 ? 122.979 119.375 106.666 1.00 90.58  ? 108 LEU A CA  1 
ATOM   445  C C   . LEU A 1 108 ? 122.514 118.880 105.291 1.00 76.21  ? 108 LEU A C   1 
ATOM   446  O O   . LEU A 1 108 ? 121.323 118.632 105.132 1.00 85.67  ? 108 LEU A O   1 
ATOM   447  C CB  . LEU A 1 108 ? 123.244 120.883 106.667 1.00 86.29  ? 108 LEU A CB  1 
ATOM   448  C CG  . LEU A 1 108 ? 122.099 121.744 106.145 1.00 92.25  ? 108 LEU A CG  1 
ATOM   449  C CD1 . LEU A 1 108 ? 120.886 121.594 107.050 1.00 95.88  ? 108 LEU A CD1 1 
ATOM   450  C CD2 . LEU A 1 108 ? 122.538 123.190 105.984 1.00 124.09 ? 108 LEU A CD2 1 
ATOM   451  N N   . LEU A 1 109 ? 123.410 118.741 104.299 1.00 63.48  ? 109 LEU A N   1 
ATOM   452  C CA  . LEU A 1 109 ? 122.990 118.273 102.989 1.00 73.18  ? 109 LEU A CA  1 
ATOM   453  C C   . LEU A 1 109 ? 122.374 116.879 103.079 1.00 70.90  ? 109 LEU A C   1 
ATOM   454  O O   . LEU A 1 109 ? 121.482 116.543 102.292 1.00 64.39  ? 109 LEU A O   1 
ATOM   455  C CB  . LEU A 1 109 ? 124.177 118.266 102.022 1.00 83.13  ? 109 LEU A CB  1 
ATOM   456  C CG  . LEU A 1 109 ? 124.584 119.588 101.401 1.00 79.76  ? 109 LEU A CG  1 
ATOM   457  C CD1 . LEU A 1 109 ? 125.788 119.380 100.504 1.00 82.68  ? 109 LEU A CD1 1 
ATOM   458  C CD2 . LEU A 1 109 ? 123.442 120.166 100.597 1.00 81.19  ? 109 LEU A CD2 1 
ATOM   459  N N   . TRP A 1 110 ? 122.830 116.055 104.031 1.00 67.38  ? 110 TRP A N   1 
ATOM   460  C CA  . TRP A 1 110 ? 122.206 114.753 104.205 1.00 71.46  ? 110 TRP A CA  1 
ATOM   461  C C   . TRP A 1 110 ? 120.851 114.887 104.906 1.00 75.54  ? 110 TRP A C   1 
ATOM   462  O O   . TRP A 1 110 ? 119.869 114.309 104.451 1.00 90.04  ? 110 TRP A O   1 
ATOM   463  C CB  . TRP A 1 110 ? 123.136 113.782 104.925 1.00 71.18  ? 110 TRP A CB  1 
ATOM   464  C CG  . TRP A 1 110 ? 122.519 112.419 104.991 1.00 63.12  ? 110 TRP A CG  1 
ATOM   465  C CD1 . TRP A 1 110 ? 122.158 111.742 106.123 1.00 80.20  ? 110 TRP A CD1 1 
ATOM   466  C CD2 . TRP A 1 110 ? 122.087 111.614 103.880 1.00 65.68  ? 110 TRP A CD2 1 
ATOM   467  N NE1 . TRP A 1 110 ? 121.556 110.563 105.794 1.00 79.30  ? 110 TRP A NE1 1 
ATOM   468  C CE2 . TRP A 1 110 ? 121.498 110.451 104.432 1.00 81.93  ? 110 TRP A CE2 1 
ATOM   469  C CE3 . TRP A 1 110 ? 122.139 111.746 102.486 1.00 69.25  ? 110 TRP A CE3 1 
ATOM   470  C CZ2 . TRP A 1 110 ? 120.991 109.429 103.634 1.00 88.87  ? 110 TRP A CZ2 1 
ATOM   471  C CZ3 . TRP A 1 110 ? 121.613 110.744 101.691 1.00 75.39  ? 110 TRP A CZ3 1 
ATOM   472  C CH2 . TRP A 1 110 ? 121.046 109.607 102.259 1.00 83.97  ? 110 TRP A CH2 1 
ATOM   473  N N   . SER A 1 111 ? 120.761 115.674 105.981 1.00 81.14  ? 111 SER A N   1 
ATOM   474  C CA  . SER A 1 111 ? 119.492 115.899 106.663 1.00 88.54  ? 111 SER A CA  1 
ATOM   475  C C   . SER A 1 111 ? 118.416 116.447 105.718 1.00 79.63  ? 111 SER A C   1 
ATOM   476  O O   . SER A 1 111 ? 117.247 116.106 105.836 1.00 85.63  ? 111 SER A O   1 
ATOM   477  C CB  . SER A 1 111 ? 119.674 116.812 107.849 1.00 97.72  ? 111 SER A CB  1 
ATOM   478  O OG  . SER A 1 111 ? 120.695 116.321 108.704 1.00 129.88 ? 111 SER A OG  1 
ATOM   479  N N   . VAL A 1 112 ? 118.803 117.326 104.787 1.00 78.19  ? 112 VAL A N   1 
ATOM   480  C CA  . VAL A 1 112 ? 117.906 117.848 103.763 1.00 73.58  ? 112 VAL A CA  1 
ATOM   481  C C   . VAL A 1 112 ? 117.562 116.760 102.732 1.00 66.71  ? 112 VAL A C   1 
ATOM   482  O O   . VAL A 1 112 ? 116.401 116.635 102.376 1.00 83.93  ? 112 VAL A O   1 
ATOM   483  C CB  . VAL A 1 112 ? 118.484 119.119 103.118 1.00 73.54  ? 112 VAL A CB  1 
ATOM   484  C CG1 . VAL A 1 112 ? 117.816 119.488 101.805 1.00 91.56  ? 112 VAL A CG1 1 
ATOM   485  C CG2 . VAL A 1 112 ? 118.454 120.272 104.103 1.00 85.99  ? 112 VAL A CG2 1 
ATOM   486  N N   . THR A 1 113 ? 118.521 115.939 102.277 1.00 66.49  ? 113 THR A N   1 
ATOM   487  C CA  . THR A 1 113 ? 118.223 114.907 101.295 1.00 63.70  ? 113 THR A CA  1 
ATOM   488  C C   . THR A 1 113 ? 117.207 113.896 101.832 1.00 60.95  ? 113 THR A C   1 
ATOM   489  O O   . THR A 1 113 ? 116.381 113.368 101.083 1.00 55.61  ? 113 THR A O   1 
ATOM   490  C CB  . THR A 1 113 ? 119.483 114.149 100.869 1.00 59.46  ? 113 THR A CB  1 
ATOM   491  O OG1 . THR A 1 113 ? 120.454 115.056 100.379 1.00 51.34  ? 113 THR A OG1 1 
ATOM   492  C CG2 . THR A 1 113 ? 119.212 113.098 99.815  1.00 62.25  ? 113 THR A CG2 1 
ATOM   493  N N   . VAL A 1 114 ? 117.294 113.588 103.125 1.00 60.05  ? 114 VAL A N   1 
ATOM   494  C CA  . VAL A 1 114 ? 116.406 112.633 103.763 1.00 69.76  ? 114 VAL A CA  1 
ATOM   495  C C   . VAL A 1 114 ? 115.001 113.227 103.886 1.00 62.18  ? 114 VAL A C   1 
ATOM   496  O O   . VAL A 1 114 ? 114.038 112.595 103.491 1.00 57.01  ? 114 VAL A O   1 
ATOM   497  C CB  . VAL A 1 114 ? 116.964 112.177 105.134 1.00 71.74  ? 114 VAL A CB  1 
ATOM   498  C CG1 . VAL A 1 114 ? 115.907 111.519 106.030 1.00 59.25  ? 114 VAL A CG1 1 
ATOM   499  C CG2 . VAL A 1 114 ? 118.182 111.267 104.943 1.00 68.04  ? 114 VAL A CG2 1 
ATOM   500  N N   . SER A 1 115 ? 114.890 114.440 104.426 1.00 64.93  ? 115 SER A N   1 
ATOM   501  C CA  . SER A 1 115 ? 113.618 115.005 104.844 1.00 75.43  ? 115 SER A CA  1 
ATOM   502  C C   . SER A 1 115 ? 112.861 115.762 103.751 1.00 69.65  ? 115 SER A C   1 
ATOM   503  O O   . SER A 1 115 ? 111.665 115.963 103.909 1.00 99.02  ? 115 SER A O   1 
ATOM   504  C CB  . SER A 1 115 ? 113.841 115.913 106.038 1.00 83.51  ? 115 SER A CB  1 
ATOM   505  O OG  . SER A 1 115 ? 114.623 117.017 105.673 1.00 67.26  ? 115 SER A OG  1 
ATOM   506  N N   . ILE A 1 116 ? 113.504 116.172 102.655 1.00 71.54  ? 116 ILE A N   1 
ATOM   507  C CA  . ILE A 1 116 ? 112.848 116.952 101.596 1.00 69.04  ? 116 ILE A CA  1 
ATOM   508  C C   . ILE A 1 116 ? 111.641 116.203 101.019 1.00 65.00  ? 116 ILE A C   1 
ATOM   509  O O   . ILE A 1 116 ? 110.707 116.839 100.528 1.00 80.06  ? 116 ILE A O   1 
ATOM   510  C CB  . ILE A 1 116 ? 113.844 117.333 100.470 1.00 81.74  ? 116 ILE A CB  1 
ATOM   511  C CG1 . ILE A 1 116 ? 113.328 118.462 99.587  1.00 76.78  ? 116 ILE A CG1 1 
ATOM   512  C CG2 . ILE A 1 116 ? 114.257 116.123 99.645  1.00 72.71  ? 116 ILE A CG2 1 
ATOM   513  C CD1 . ILE A 1 116 ? 113.245 119.764 100.343 1.00 90.33  ? 116 ILE A CD1 1 
ATOM   514  N N   . PHE A 1 117 ? 111.640 114.868 101.133 1.00 59.01  ? 117 PHE A N   1 
ATOM   515  C CA  . PHE A 1 117 ? 110.523 114.009 100.780 1.00 59.02  ? 117 PHE A CA  1 
ATOM   516  C C   . PHE A 1 117 ? 109.217 114.489 101.409 1.00 51.20  ? 117 PHE A C   1 
ATOM   517  O O   . PHE A 1 117 ? 108.180 114.498 100.749 1.00 55.07  ? 117 PHE A O   1 
ATOM   518  C CB  . PHE A 1 117 ? 110.871 112.591 101.214 1.00 64.33  ? 117 PHE A CB  1 
ATOM   519  C CG  . PHE A 1 117 ? 109.882 111.501 100.902 1.00 86.35  ? 117 PHE A CG  1 
ATOM   520  C CD1 . PHE A 1 117 ? 109.622 111.110 99.592  1.00 99.68  ? 117 PHE A CD1 1 
ATOM   521  C CD2 . PHE A 1 117 ? 109.254 110.831 101.942 1.00 96.46  ? 117 PHE A CD2 1 
ATOM   522  C CE1 . PHE A 1 117 ? 108.737 110.080 99.331  1.00 106.39 ? 117 PHE A CE1 1 
ATOM   523  C CE2 . PHE A 1 117 ? 108.384 109.781 101.676 1.00 104.56 ? 117 PHE A CE2 1 
ATOM   524  C CZ  . PHE A 1 117 ? 108.120 109.424 100.371 1.00 109.35 ? 117 PHE A CZ  1 
ATOM   525  N N   . ALA A 1 118 ? 109.264 114.917 102.672 1.00 55.90  ? 118 ALA A N   1 
ATOM   526  C CA  . ALA A 1 118 ? 108.082 115.357 103.401 1.00 60.24  ? 118 ALA A CA  1 
ATOM   527  C C   . ALA A 1 118 ? 107.517 116.680 102.869 1.00 56.07  ? 118 ALA A C   1 
ATOM   528  O O   . ALA A 1 118 ? 106.315 116.898 102.941 1.00 61.95  ? 118 ALA A O   1 
ATOM   529  C CB  . ALA A 1 118 ? 108.415 115.418 104.886 1.00 71.82  ? 118 ALA A CB  1 
ATOM   530  N N   . ILE A 1 119 ? 108.357 117.584 102.343 1.00 62.45  ? 119 ILE A N   1 
ATOM   531  C CA  . ILE A 1 119 ? 107.872 118.786 101.665 1.00 60.78  ? 119 ILE A CA  1 
ATOM   532  C C   . ILE A 1 119 ? 107.254 118.402 100.313 1.00 67.73  ? 119 ILE A C   1 
ATOM   533  O O   . ILE A 1 119 ? 106.267 118.990 99.888  1.00 74.67  ? 119 ILE A O   1 
ATOM   534  C CB  . ILE A 1 119 ? 108.976 119.845 101.520 1.00 61.12  ? 119 ILE A CB  1 
ATOM   535  C CG1 . ILE A 1 119 ? 109.593 120.202 102.877 1.00 92.26  ? 119 ILE A CG1 1 
ATOM   536  C CG2 . ILE A 1 119 ? 108.449 121.072 100.800 1.00 64.48  ? 119 ILE A CG2 1 
ATOM   537  C CD1 . ILE A 1 119 ? 108.589 120.765 103.878 1.00 117.54 ? 119 ILE A CD1 1 
ATOM   538  N N   . GLY A 1 120 ? 107.809 117.391 99.638  1.00 64.92  ? 120 GLY A N   1 
ATOM   539  C CA  . GLY A 1 120 ? 107.165 116.798 98.482  1.00 62.81  ? 120 GLY A CA  1 
ATOM   540  C C   . GLY A 1 120 ? 105.780 116.265 98.825  1.00 61.33  ? 120 GLY A C   1 
ATOM   541  O O   . GLY A 1 120 ? 104.825 116.523 98.108  1.00 55.56  ? 120 GLY A O   1 
ATOM   542  N N   . GLY A 1 121 ? 105.664 115.524 99.934  1.00 63.24  ? 121 GLY A N   1 
ATOM   543  C CA  . GLY A 1 121 ? 104.388 115.005 100.408 1.00 59.70  ? 121 GLY A CA  1 
ATOM   544  C C   . GLY A 1 121 ? 103.369 116.104 100.697 1.00 57.32  ? 121 GLY A C   1 
ATOM   545  O O   . GLY A 1 121 ? 102.203 115.989 100.337 1.00 63.10  ? 121 GLY A O   1 
ATOM   546  N N   . LEU A 1 122 ? 103.808 117.188 101.330 1.00 61.01  ? 122 LEU A N   1 
ATOM   547  C CA  . LEU A 1 122 ? 102.950 118.341 101.565 1.00 54.48  ? 122 LEU A CA  1 
ATOM   548  C C   . LEU A 1 122 ? 102.470 118.925 100.239 1.00 66.30  ? 122 LEU A C   1 
ATOM   549  O O   . LEU A 1 122 ? 101.269 119.068 100.054 1.00 103.27 ? 122 LEU A O   1 
ATOM   550  C CB  . LEU A 1 122 ? 103.724 119.364 102.402 1.00 59.28  ? 122 LEU A CB  1 
ATOM   551  C CG  . LEU A 1 122 ? 103.010 120.665 102.704 1.00 70.56  ? 122 LEU A CG  1 
ATOM   552  C CD1 . LEU A 1 122 ? 101.719 120.353 103.415 1.00 84.47  ? 122 LEU A CD1 1 
ATOM   553  C CD2 . LEU A 1 122 ? 103.877 121.564 103.568 1.00 88.80  ? 122 LEU A CD2 1 
ATOM   554  N N   . VAL A 1 123 ? 103.373 119.224 99.296  1.00 75.46  ? 123 VAL A N   1 
ATOM   555  C CA  . VAL A 1 123 ? 103.010 119.778 97.996  1.00 79.64  ? 123 VAL A CA  1 
ATOM   556  C C   . VAL A 1 123 ? 102.076 118.828 97.249  1.00 69.67  ? 123 VAL A C   1 
ATOM   557  O O   . VAL A 1 123 ? 101.084 119.266 96.671  1.00 82.78  ? 123 VAL A O   1 
ATOM   558  C CB  . VAL A 1 123 ? 104.255 120.133 97.153  1.00 85.67  ? 123 VAL A CB  1 
ATOM   559  C CG1 . VAL A 1 123 ? 103.914 120.417 95.700  1.00 87.01  ? 123 VAL A CG1 1 
ATOM   560  C CG2 . VAL A 1 123 ? 104.992 121.320 97.757  1.00 114.03 ? 123 VAL A CG2 1 
ATOM   561  N N   . GLY A 1 124 ? 102.383 117.535 97.270  1.00 78.10  ? 124 GLY A N   1 
ATOM   562  C CA  . GLY A 1 124 ? 101.561 116.527 96.623  1.00 88.60  ? 124 GLY A CA  1 
ATOM   563  C C   . GLY A 1 124 ? 100.153 116.420 97.208  1.00 75.76  ? 124 GLY A C   1 
ATOM   564  O O   . GLY A 1 124 ? 99.212  116.220 96.449  1.00 87.63  ? 124 GLY A O   1 
ATOM   565  N N   . THR A 1 125 ? 99.990  116.586 98.528  1.00 65.86  ? 125 THR A N   1 
ATOM   566  C CA  . THR A 1 125 ? 98.676  116.519 99.158  1.00 69.08  ? 125 THR A CA  1 
ATOM   567  C C   . THR A 1 125 ? 97.776  117.666 98.698  1.00 72.42  ? 125 THR A C   1 
ATOM   568  O O   . THR A 1 125 ? 96.587  117.468 98.465  1.00 87.22  ? 125 THR A O   1 
ATOM   569  C CB  . THR A 1 125 ? 98.768  116.541 100.685 1.00 82.77  ? 125 THR A CB  1 
ATOM   570  O OG1 . THR A 1 125 ? 99.543  115.410 101.079 1.00 118.02 ? 125 THR A OG1 1 
ATOM   571  C CG2 . THR A 1 125 ? 97.423  116.457 101.370 1.00 91.77  ? 125 THR A CG2 1 
ATOM   572  N N   . LEU A 1 126 ? 98.334  118.873 98.557  1.00 66.40  ? 126 LEU A N   1 
ATOM   573  C CA  . LEU A 1 126 ? 97.556  120.037 98.172  1.00 79.60  ? 126 LEU A CA  1 
ATOM   574  C C   . LEU A 1 126 ? 97.299  120.081 96.656  1.00 74.10  ? 126 LEU A C   1 
ATOM   575  O O   . LEU A 1 126 ? 96.383  120.758 96.206  1.00 84.06  ? 126 LEU A O   1 
ATOM   576  C CB  . LEU A 1 126 ? 98.284  121.292 98.685  1.00 99.41  ? 126 LEU A CB  1 
ATOM   577  C CG  . LEU A 1 126 ? 98.498  121.326 100.206 1.00 104.63 ? 126 LEU A CG  1 
ATOM   578  C CD1 . LEU A 1 126 ? 99.196  122.605 100.626 1.00 141.04 ? 126 LEU A CD1 1 
ATOM   579  C CD2 . LEU A 1 126 ? 97.198  121.161 100.986 1.00 106.80 ? 126 LEU A CD2 1 
ATOM   580  N N   . ILE A 1 127 ? 98.050  119.324 95.855  1.00 83.50  ? 127 ILE A N   1 
ATOM   581  C CA  . ILE A 1 127 ? 97.774  119.136 94.431  1.00 93.39  ? 127 ILE A CA  1 
ATOM   582  C C   . ILE A 1 127 ? 96.523  118.266 94.207  1.00 99.81  ? 127 ILE A C   1 
ATOM   583  O O   . ILE A 1 127 ? 95.786  118.505 93.253  1.00 113.23 ? 127 ILE A O   1 
ATOM   584  C CB  . ILE A 1 127 ? 99.040  118.575 93.735  1.00 101.47 ? 127 ILE A CB  1 
ATOM   585  C CG1 . ILE A 1 127 ? 100.030 119.710 93.474  1.00 121.57 ? 127 ILE A CG1 1 
ATOM   586  C CG2 . ILE A 1 127 ? 98.733  117.795 92.466  1.00 97.70  ? 127 ILE A CG2 1 
ATOM   587  C CD1 . ILE A 1 127 ? 101.406 119.239 93.056  1.00 129.23 ? 127 ILE A CD1 1 
ATOM   588  N N   . VAL A 1 128 ? 96.211  117.306 95.099  1.00 101.91 ? 128 VAL A N   1 
ATOM   589  C CA  . VAL A 1 128 ? 95.057  116.432 94.919  1.00 88.88  ? 128 VAL A CA  1 
ATOM   590  C C   . VAL A 1 128 ? 93.766  117.234 95.002  1.00 108.65 ? 128 VAL A C   1 
ATOM   591  O O   . VAL A 1 128 ? 92.827  116.940 94.264  1.00 126.79 ? 128 VAL A O   1 
ATOM   592  C CB  . VAL A 1 128 ? 95.056  115.262 95.924  1.00 92.58  ? 128 VAL A CB  1 
ATOM   593  C CG1 . VAL A 1 128 ? 93.723  114.530 96.026  1.00 130.38 ? 128 VAL A CG1 1 
ATOM   594  C CG2 . VAL A 1 128 ? 96.136  114.274 95.581  1.00 91.47  ? 128 VAL A CG2 1 
ATOM   595  N N   . LYS A 1 129 ? 93.702  118.251 95.878  1.00 136.09 ? 129 LYS A N   1 
ATOM   596  C CA  . LYS A 1 129 ? 92.532  119.102 96.044  1.00 145.97 ? 129 LYS A CA  1 
ATOM   597  C C   . LYS A 1 129 ? 92.063  119.661 94.693  1.00 131.06 ? 129 LYS A C   1 
ATOM   598  O O   . LYS A 1 129 ? 90.861  119.720 94.424  1.00 127.10 ? 129 LYS A O   1 
ATOM   599  C CB  . LYS A 1 129 ? 92.847  120.213 97.057  1.00 136.52 ? 129 LYS A CB  1 
ATOM   600  C CG  . LYS A 1 129 ? 91.651  121.037 97.518  1.00 178.44 ? 129 LYS A CG  1 
ATOM   601  C CD  . LYS A 1 129 ? 91.344  122.262 96.674  1.00 204.74 ? 129 LYS A CD  1 
ATOM   602  C CE  . LYS A 1 129 ? 90.014  122.901 97.025  1.00 203.76 ? 129 LYS A CE  1 
ATOM   603  N NZ  . LYS A 1 129 ? 89.697  124.043 96.134  1.00 195.25 ? 129 LYS A NZ  1 
ATOM   604  N N   . MET A 1 130 ? 93.021  120.078 93.846  1.00 114.06 ? 130 MET A N   1 
ATOM   605  C CA  . MET A 1 130 ? 92.740  120.669 92.548  1.00 105.33 ? 130 MET A CA  1 
ATOM   606  C C   . MET A 1 130 ? 92.553  119.599 91.464  1.00 114.30 ? 130 MET A C   1 
ATOM   607  O O   . MET A 1 130 ? 91.604  119.704 90.688  1.00 157.28 ? 130 MET A O   1 
ATOM   608  C CB  . MET A 1 130 ? 93.873  121.615 92.159  1.00 122.14 ? 130 MET A CB  1 
ATOM   609  C CG  . MET A 1 130 ? 94.037  122.752 93.160  1.00 148.53 ? 130 MET A CG  1 
ATOM   610  S SD  . MET A 1 130 ? 95.315  123.981 92.751  1.00 247.31 ? 130 MET A SD  1 
ATOM   611  C CE  . MET A 1 130 ? 96.792  122.973 92.597  1.00 273.02 ? 130 MET A CE  1 
ATOM   612  N N   . ILE A 1 131 ? 93.418  118.572 91.396  1.00 93.25  ? 131 ILE A N   1 
ATOM   613  C CA  . ILE A 1 131 ? 93.362  117.573 90.336  1.00 109.02 ? 131 ILE A CA  1 
ATOM   614  C C   . ILE A 1 131 ? 92.107  116.698 90.457  1.00 160.16 ? 131 ILE A C   1 
ATOM   615  O O   . ILE A 1 131 ? 91.537  116.300 89.443  1.00 197.80 ? 131 ILE A O   1 
ATOM   616  C CB  . ILE A 1 131 ? 94.663  116.733 90.299  1.00 138.12 ? 131 ILE A CB  1 
ATOM   617  C CG1 . ILE A 1 131 ? 95.851  117.588 89.856  1.00 169.12 ? 131 ILE A CG1 1 
ATOM   618  C CG2 . ILE A 1 131 ? 94.530  115.480 89.428  1.00 151.35 ? 131 ILE A CG2 1 
ATOM   619  C CD1 . ILE A 1 131 ? 97.144  116.806 89.662  1.00 180.47 ? 131 ILE A CD1 1 
ATOM   620  N N   . GLY A 1 132 ? 91.652  116.389 91.683  1.00 204.30 ? 132 GLY A N   1 
ATOM   621  C CA  . GLY A 1 132 ? 90.571  115.438 91.920  1.00 213.08 ? 132 GLY A CA  1 
ATOM   622  C C   . GLY A 1 132 ? 89.224  115.828 91.304  1.00 205.95 ? 132 GLY A C   1 
ATOM   623  O O   . GLY A 1 132 ? 88.357  114.968 91.149  1.00 247.86 ? 132 GLY A O   1 
ATOM   624  N N   . LYS A 1 133 ? 89.040  117.117 90.970  1.00 175.12 ? 133 LYS A N   1 
ATOM   625  C CA  . LYS A 1 133 ? 87.843  117.604 90.298  1.00 176.85 ? 133 LYS A CA  1 
ATOM   626  C C   . LYS A 1 133 ? 87.876  117.345 88.787  1.00 167.83 ? 133 LYS A C   1 
ATOM   627  O O   . LYS A 1 133 ? 86.823  117.330 88.150  1.00 162.53 ? 133 LYS A O   1 
ATOM   628  C CB  . LYS A 1 133 ? 87.699  119.108 90.548  1.00 223.60 ? 133 LYS A CB  1 
ATOM   629  C CG  . LYS A 1 133 ? 87.621  119.517 92.015  1.00 243.94 ? 133 LYS A CG  1 
ATOM   630  C CD  . LYS A 1 133 ? 87.188  120.955 92.244  1.00 264.76 ? 133 LYS A CD  1 
ATOM   631  C CE  . LYS A 1 133 ? 88.148  121.990 91.691  1.00 269.83 ? 133 LYS A CE  1 
ATOM   632  N NZ  . LYS A 1 133 ? 87.676  123.373 91.944  1.00 249.46 ? 133 LYS A NZ  1 
ATOM   633  N N   . VAL A 1 134 ? 89.077  117.156 88.208  1.00 162.01 ? 134 VAL A N   1 
ATOM   634  C CA  . VAL A 1 134 ? 89.291  117.143 86.764  1.00 155.76 ? 134 VAL A CA  1 
ATOM   635  C C   . VAL A 1 134 ? 89.438  115.714 86.225  1.00 155.83 ? 134 VAL A C   1 
ATOM   636  O O   . VAL A 1 134 ? 88.713  115.351 85.297  1.00 181.81 ? 134 VAL A O   1 
ATOM   637  C CB  . VAL A 1 134 ? 90.507  118.017 86.392  1.00 179.30 ? 134 VAL A CB  1 
ATOM   638  C CG1 . VAL A 1 134 ? 90.894  117.919 84.917  1.00 188.31 ? 134 VAL A CG1 1 
ATOM   639  C CG2 . VAL A 1 134 ? 90.273  119.469 86.794  1.00 193.52 ? 134 VAL A CG2 1 
ATOM   640  N N   . LEU A 1 135 ? 90.370  114.912 86.771  1.00 157.34 ? 135 LEU A N   1 
ATOM   641  C CA  . LEU A 1 135 ? 90.725  113.629 86.169  1.00 167.42 ? 135 LEU A CA  1 
ATOM   642  C C   . LEU A 1 135 ? 89.743  112.524 86.571  1.00 134.97 ? 135 LEU A C   1 
ATOM   643  O O   . LEU A 1 135 ? 89.124  111.892 85.709  1.00 127.63 ? 135 LEU A O   1 
ATOM   644  C CB  . LEU A 1 135 ? 92.155  113.245 86.572  1.00 165.50 ? 135 LEU A CB  1 
ATOM   645  C CG  . LEU A 1 135 ? 93.274  114.114 85.993  1.00 187.16 ? 135 LEU A CG  1 
ATOM   646  C CD1 . LEU A 1 135 ? 94.645  113.567 86.394  1.00 180.21 ? 135 LEU A CD1 1 
ATOM   647  C CD2 . LEU A 1 135 ? 93.175  114.215 84.473  1.00 207.63 ? 135 LEU A CD2 1 
ATOM   648  N N   . GLY A 1 136 ? 89.634  112.274 87.878  1.00 117.10 ? 136 GLY A N   1 
ATOM   649  C CA  . GLY A 1 136 ? 88.920  111.107 88.394  1.00 125.33 ? 136 GLY A CA  1 
ATOM   650  C C   . GLY A 1 136 ? 89.810  110.283 89.332  1.00 106.57 ? 136 GLY A C   1 
ATOM   651  O O   . GLY A 1 136 ? 90.917  110.693 89.665  1.00 123.95 ? 136 GLY A O   1 
ATOM   652  N N   . ARG A 1 137 ? 89.320  109.130 89.787  1.00 101.06 ? 137 ARG A N   1 
ATOM   653  C CA  . ARG A 1 137 ? 90.052  108.323 90.752  1.00 125.00 ? 137 ARG A CA  1 
ATOM   654  C C   . ARG A 1 137 ? 91.103  107.483 90.029  1.00 127.60 ? 137 ARG A C   1 
ATOM   655  O O   . ARG A 1 137 ? 92.280  107.547 90.379  1.00 137.84 ? 137 ARG A O   1 
ATOM   656  C CB  . ARG A 1 137 ? 89.135  107.408 91.579  1.00 158.29 ? 137 ARG A CB  1 
ATOM   657  C CG  . ARG A 1 137 ? 88.078  108.132 92.402  1.00 179.62 ? 137 ARG A CG  1 
ATOM   658  C CD  . ARG A 1 137 ? 88.597  109.297 93.225  1.00 170.62 ? 137 ARG A CD  1 
ATOM   659  N NE  . ARG A 1 137 ? 87.591  109.728 94.190  1.00 182.47 ? 137 ARG A NE  1 
ATOM   660  C CZ  . ARG A 1 137 ? 87.703  110.782 94.988  1.00 203.44 ? 137 ARG A CZ  1 
ATOM   661  N NH1 . ARG A 1 137 ? 86.802  110.986 95.934  1.00 232.19 ? 137 ARG A NH1 1 
ATOM   662  N NH2 . ARG A 1 137 ? 88.734  111.600 94.862  1.00 215.35 ? 137 ARG A NH2 1 
ATOM   663  N N   . LYS A 1 138 ? 90.699  106.687 89.029  1.00 145.85 ? 138 LYS A N   1 
ATOM   664  C CA  . LYS A 1 138 ? 91.631  105.790 88.360  1.00 136.98 ? 138 LYS A CA  1 
ATOM   665  C C   . LYS A 1 138 ? 92.711  106.599 87.634  1.00 105.43 ? 138 LYS A C   1 
ATOM   666  O O   . LYS A 1 138 ? 93.896  106.327 87.804  1.00 123.60 ? 138 LYS A O   1 
ATOM   667  C CB  . LYS A 1 138 ? 90.902  104.842 87.394  1.00 151.27 ? 138 LYS A CB  1 
ATOM   668  C CG  . LYS A 1 138 ? 91.794  103.787 86.756  1.00 152.05 ? 138 LYS A CG  1 
ATOM   669  C CD  . LYS A 1 138 ? 91.066  102.856 85.810  1.00 141.29 ? 138 LYS A CD  1 
ATOM   670  C CE  . LYS A 1 138 ? 90.613  103.514 84.526  1.00 152.95 ? 138 LYS A CE  1 
ATOM   671  N NZ  . LYS A 1 138 ? 90.171  102.532 83.504  1.00 145.76 ? 138 LYS A NZ  1 
ATOM   672  N N   . HIS A 1 139 ? 92.320  107.583 86.817  1.00 95.57  ? 139 HIS A N   1 
ATOM   673  C CA  . HIS A 1 139 ? 93.271  108.305 85.987  1.00 86.49  ? 139 HIS A CA  1 
ATOM   674  C C   . HIS A 1 139 ? 94.264  109.122 86.814  1.00 73.96  ? 139 HIS A C   1 
ATOM   675  O O   . HIS A 1 139 ? 95.351  109.391 86.316  1.00 96.81  ? 139 HIS A O   1 
ATOM   676  C CB  . HIS A 1 139 ? 92.570  109.234 84.984  1.00 111.12 ? 139 HIS A CB  1 
ATOM   677  C CG  . HIS A 1 139 ? 91.699  108.560 83.981  1.00 116.36 ? 139 HIS A CG  1 
ATOM   678  N ND1 . HIS A 1 139 ? 91.971  107.400 83.304  1.00 117.90 ? 139 HIS A ND1 1 
ATOM   679  C CD2 . HIS A 1 139 ? 90.489  108.947 83.574  1.00 143.05 ? 139 HIS A CD2 1 
ATOM   680  C CE1 . HIS A 1 139 ? 90.970  107.137 82.481  1.00 136.43 ? 139 HIS A CE1 1 
ATOM   681  N NE2 . HIS A 1 139 ? 90.051  108.054 82.628  1.00 139.55 ? 139 HIS A NE2 1 
ATOM   682  N N   . THR A 1 140 ? 93.961  109.514 88.055  1.00 82.25  ? 140 THR A N   1 
ATOM   683  C CA  . THR A 1 140 ? 94.976  110.141 88.894  1.00 78.10  ? 140 THR A CA  1 
ATOM   684  C C   . THR A 1 140 ? 96.062  109.126 89.237  1.00 78.53  ? 140 THR A C   1 
ATOM   685  O O   . THR A 1 140 ? 97.233  109.458 89.127  1.00 115.93 ? 140 THR A O   1 
ATOM   686  C CB  . THR A 1 140 ? 94.454  110.794 90.187  1.00 71.06  ? 140 THR A CB  1 
ATOM   687  O OG1 . THR A 1 140 ? 93.502  111.801 89.875  1.00 91.13  ? 140 THR A OG1 1 
ATOM   688  C CG2 . THR A 1 140 ? 95.529  111.479 90.982  1.00 62.96  ? 140 THR A CG2 1 
ATOM   689  N N   . LEU A 1 141 ? 95.723  107.893 89.612  1.00 80.37  ? 141 LEU A N   1 
ATOM   690  C CA  . LEU A 1 141 ? 96.761  106.932 89.950  1.00 93.52  ? 141 LEU A CA  1 
ATOM   691  C C   . LEU A 1 141 ? 97.548  106.461 88.717  1.00 93.31  ? 141 LEU A C   1 
ATOM   692  O O   . LEU A 1 141 ? 98.561  105.798 88.886  1.00 126.65 ? 141 LEU A O   1 
ATOM   693  C CB  . LEU A 1 141 ? 96.148  105.740 90.702  1.00 117.28 ? 141 LEU A CB  1 
ATOM   694  C CG  . LEU A 1 141 ? 95.572  106.039 92.079  1.00 108.08 ? 141 LEU A CG  1 
ATOM   695  C CD1 . LEU A 1 141 ? 95.165  104.736 92.748  1.00 119.99 ? 141 LEU A CD1 1 
ATOM   696  C CD2 . LEU A 1 141 ? 96.578  106.779 92.932  1.00 109.87 ? 141 LEU A CD2 1 
ATOM   697  N N   . LEU A 1 142 ? 97.107  106.750 87.488  1.00 82.80  ? 142 LEU A N   1 
ATOM   698  C CA  . LEU A 1 142 ? 97.950  106.562 86.318  1.00 88.71  ? 142 LEU A CA  1 
ATOM   699  C C   . LEU A 1 142 ? 98.832  107.801 86.100  1.00 88.40  ? 142 LEU A C   1 
ATOM   700  O O   . LEU A 1 142 ? 100.043 107.660 85.979  1.00 83.22  ? 142 LEU A O   1 
ATOM   701  C CB  . LEU A 1 142 ? 97.087  106.257 85.078  1.00 104.84 ? 142 LEU A CB  1 
ATOM   702  C CG  . LEU A 1 142 ? 96.229  104.999 85.138  1.00 111.27 ? 142 LEU A CG  1 
ATOM   703  C CD1 . LEU A 1 142 ? 95.444  104.831 83.848  1.00 133.00 ? 142 LEU A CD1 1 
ATOM   704  C CD2 . LEU A 1 142 ? 97.067  103.781 85.399  1.00 122.64 ? 142 LEU A CD2 1 
ATOM   705  N N   . ALA A 1 143 ? 98.241  108.999 86.005  1.00 102.74 ? 143 ALA A N   1 
ATOM   706  C CA  . ALA A 1 143 ? 98.973  110.230 85.733  1.00 97.95  ? 143 ALA A CA  1 
ATOM   707  C C   . ALA A 1 143 ? 99.977  110.522 86.848  1.00 75.51  ? 143 ALA A C   1 
ATOM   708  O O   . ALA A 1 143 ? 100.959 111.238 86.644  1.00 103.19 ? 143 ALA A O   1 
ATOM   709  C CB  . ALA A 1 143 ? 98.001  111.388 85.548  1.00 112.56 ? 143 ALA A CB  1 
ATOM   710  N N   . ASN A 1 144 ? 99.748  109.964 88.035  1.00 63.07  ? 144 ASN A N   1 
ATOM   711  C CA  . ASN A 1 144 ? 100.652 110.114 89.168  1.00 74.96  ? 144 ASN A CA  1 
ATOM   712  C C   . ASN A 1 144 ? 101.995 109.434 88.907  1.00 87.42  ? 144 ASN A C   1 
ATOM   713  O O   . ASN A 1 144 ? 103.021 109.868 89.428  1.00 93.04  ? 144 ASN A O   1 
ATOM   714  C CB  . ASN A 1 144 ? 100.003 109.516 90.409  1.00 99.66  ? 144 ASN A CB  1 
ATOM   715  C CG  . ASN A 1 144 ? 100.945 109.401 91.570  1.00 86.53  ? 144 ASN A CG  1 
ATOM   716  O OD1 . ASN A 1 144 ? 101.124 110.373 92.280  1.00 71.53  ? 144 ASN A OD1 1 
ATOM   717  N ND2 . ASN A 1 144 ? 101.501 108.214 91.759  1.00 94.33  ? 144 ASN A ND2 1 
ATOM   718  N N   . ASN A 1 145 ? 102.021 108.366 88.097  1.00 90.02  ? 145 ASN A N   1 
ATOM   719  C CA  . ASN A 1 145 ? 103.259 107.644 87.845  1.00 84.89  ? 145 ASN A CA  1 
ATOM   720  C C   . ASN A 1 145 ? 104.127 108.348 86.796  1.00 96.56  ? 145 ASN A C   1 
ATOM   721  O O   . ASN A 1 145 ? 105.217 107.871 86.488  1.00 102.03 ? 145 ASN A O   1 
ATOM   722  C CB  . ASN A 1 145 ? 102.987 106.180 87.523  1.00 80.09  ? 145 ASN A CB  1 
ATOM   723  C CG  . ASN A 1 145 ? 102.479 105.473 88.758  1.00 108.83 ? 145 ASN A CG  1 
ATOM   724  O OD1 . ASN A 1 145 ? 102.208 106.104 89.781  1.00 112.92 ? 145 ASN A OD1 1 
ATOM   725  N ND2 . ASN A 1 145 ? 102.333 104.170 88.659  1.00 124.89 ? 145 ASN A ND2 1 
ATOM   726  N N   . GLY A 1 146 ? 103.683 109.519 86.320  1.00 118.27 ? 146 GLY A N   1 
ATOM   727  C CA  . GLY A 1 146 ? 104.578 110.528 85.782  1.00 115.38 ? 146 GLY A CA  1 
ATOM   728  C C   . GLY A 1 146 ? 105.624 110.935 86.817  1.00 75.05  ? 146 GLY A C   1 
ATOM   729  O O   . GLY A 1 146 ? 106.796 111.017 86.482  1.00 86.63  ? 146 GLY A O   1 
ATOM   730  N N   . PHE A 1 147 ? 105.200 111.166 88.062  1.00 59.46  ? 147 PHE A N   1 
ATOM   731  C CA  . PHE A 1 147 ? 106.092 111.582 89.126  1.00 74.91  ? 147 PHE A CA  1 
ATOM   732  C C   . PHE A 1 147 ? 106.970 110.429 89.607  1.00 82.93  ? 147 PHE A C   1 
ATOM   733  O O   . PHE A 1 147 ? 108.169 110.617 89.759  1.00 120.83 ? 147 PHE A O   1 
ATOM   734  C CB  . PHE A 1 147 ? 105.328 112.180 90.314  1.00 90.41  ? 147 PHE A CB  1 
ATOM   735  C CG  . PHE A 1 147 ? 104.470 113.382 90.016  1.00 90.61  ? 147 PHE A CG  1 
ATOM   736  C CD1 . PHE A 1 147 ? 104.986 114.485 89.373  1.00 96.54  ? 147 PHE A CD1 1 
ATOM   737  C CD2 . PHE A 1 147 ? 103.135 113.396 90.401  1.00 106.60 ? 147 PHE A CD2 1 
ATOM   738  C CE1 . PHE A 1 147 ? 104.178 115.581 89.108  1.00 133.67 ? 147 PHE A CE1 1 
ATOM   739  C CE2 . PHE A 1 147 ? 102.323 114.485 90.132  1.00 109.31 ? 147 PHE A CE2 1 
ATOM   740  C CZ  . PHE A 1 147 ? 102.852 115.576 89.482  1.00 134.83 ? 147 PHE A CZ  1 
ATOM   741  N N   . ALA A 1 148 ? 106.420 109.238 89.860  1.00 95.41  ? 148 ALA A N   1 
ATOM   742  C CA  . ALA A 1 148 ? 107.210 108.117 90.373  1.00 92.37  ? 148 ALA A CA  1 
ATOM   743  C C   . ALA A 1 148 ? 108.341 107.725 89.415  1.00 83.51  ? 148 ALA A C   1 
ATOM   744  O O   . ALA A 1 148 ? 109.438 107.439 89.870  1.00 89.93  ? 148 ALA A O   1 
ATOM   745  C CB  . ALA A 1 148 ? 106.300 106.941 90.649  1.00 104.21 ? 148 ALA A CB  1 
ATOM   746  N N   . ILE A 1 149 ? 108.103 107.718 88.090  1.00 86.90  ? 149 ILE A N   1 
ATOM   747  C CA  . ILE A 1 149 ? 109.137 107.368 87.118  1.00 82.37  ? 149 ILE A CA  1 
ATOM   748  C C   . ILE A 1 149 ? 110.087 108.547 86.869  1.00 83.88  ? 149 ILE A C   1 
ATOM   749  O O   . ILE A 1 149 ? 111.290 108.345 86.848  1.00 78.00  ? 149 ILE A O   1 
ATOM   750  C CB  . ILE A 1 149 ? 108.524 106.798 85.819  1.00 82.42  ? 149 ILE A CB  1 
ATOM   751  C CG1 . ILE A 1 149 ? 107.816 105.471 86.101  1.00 95.41  ? 149 ILE A CG1 1 
ATOM   752  C CG2 . ILE A 1 149 ? 109.567 106.645 84.723  1.00 78.93  ? 149 ILE A CG2 1 
ATOM   753  C CD1 . ILE A 1 149 ? 107.159 104.837 84.896  1.00 116.27 ? 149 ILE A CD1 1 
ATOM   754  N N   . SER A 1 150 ? 109.577 109.782 86.733  1.00 86.95  ? 150 SER A N   1 
ATOM   755  C CA  . SER A 1 150 ? 110.413 110.956 86.485  1.00 92.43  ? 150 SER A CA  1 
ATOM   756  C C   . SER A 1 150 ? 111.274 111.343 87.679  1.00 80.12  ? 150 SER A C   1 
ATOM   757  O O   . SER A 1 150 ? 112.225 112.103 87.515  1.00 82.64  ? 150 SER A O   1 
ATOM   758  C CB  . SER A 1 150 ? 109.597 112.135 86.055  1.00 132.02 ? 150 SER A CB  1 
ATOM   759  O OG  . SER A 1 150 ? 108.827 111.809 84.892  1.00 211.63 ? 150 SER A OG  1 
ATOM   760  N N   . ALA A 1 151 ? 110.949 110.829 88.875  1.00 95.17  ? 151 ALA A N   1 
ATOM   761  C CA  . ALA A 1 151 ? 111.770 111.022 90.068  1.00 87.10  ? 151 ALA A CA  1 
ATOM   762  C C   . ALA A 1 151 ? 112.795 109.895 90.198  1.00 62.39  ? 151 ALA A C   1 
ATOM   763  O O   . ALA A 1 151 ? 113.927 110.157 90.568  1.00 78.40  ? 151 ALA A O   1 
ATOM   764  C CB  . ALA A 1 151 ? 110.886 111.144 91.288  1.00 80.77  ? 151 ALA A CB  1 
ATOM   765  N N   . ALA A 1 152 ? 112.436 108.653 89.871  1.00 51.55  ? 152 ALA A N   1 
ATOM   766  C CA  . ALA A 1 152 ? 113.387 107.544 89.913  1.00 58.63  ? 152 ALA A CA  1 
ATOM   767  C C   . ALA A 1 152 ? 114.495 107.705 88.867  1.00 68.50  ? 152 ALA A C   1 
ATOM   768  O O   . ALA A 1 152 ? 115.646 107.414 89.164  1.00 75.17  ? 152 ALA A O   1 
ATOM   769  C CB  . ALA A 1 152 ? 112.662 106.236 89.732  1.00 69.84  ? 152 ALA A CB  1 
ATOM   770  N N   . LEU A 1 153 ? 114.181 108.240 87.677  1.00 83.98  ? 153 LEU A N   1 
ATOM   771  C CA  . LEU A 1 153 ? 115.175 108.447 86.625  1.00 85.42  ? 153 LEU A CA  1 
ATOM   772  C C   . LEU A 1 153 ? 116.077 109.649 86.914  1.00 82.59  ? 153 LEU A C   1 
ATOM   773  O O   . LEU A 1 153 ? 117.159 109.725 86.337  1.00 107.66 ? 153 LEU A O   1 
ATOM   774  C CB  . LEU A 1 153 ? 114.469 108.617 85.270  1.00 97.75  ? 153 LEU A CB  1 
ATOM   775  C CG  . LEU A 1 153 ? 113.760 107.374 84.738  1.00 138.39 ? 153 LEU A CG  1 
ATOM   776  C CD1 . LEU A 1 153 ? 113.068 107.675 83.414  1.00 151.48 ? 153 LEU A CD1 1 
ATOM   777  C CD2 . LEU A 1 153 ? 114.733 106.205 84.594  1.00 165.81 ? 153 LEU A CD2 1 
ATOM   778  N N   . LEU A 1 154 ? 115.647 110.592 87.778  1.00 74.65  ? 154 LEU A N   1 
ATOM   779  C CA  . LEU A 1 154 ? 116.530 111.646 88.266  1.00 74.81  ? 154 LEU A CA  1 
ATOM   780  C C   . LEU A 1 154 ? 117.524 111.071 89.270  1.00 73.79  ? 154 LEU A C   1 
ATOM   781  O O   . LEU A 1 154 ? 118.716 111.311 89.148  1.00 90.93  ? 154 LEU A O   1 
ATOM   782  C CB  . LEU A 1 154 ? 115.724 112.772 88.923  1.00 84.84  ? 154 LEU A CB  1 
ATOM   783  C CG  . LEU A 1 154 ? 115.109 113.813 87.998  1.00 101.37 ? 154 LEU A CG  1 
ATOM   784  C CD1 . LEU A 1 154 ? 114.212 114.747 88.789  1.00 115.88 ? 154 LEU A CD1 1 
ATOM   785  C CD2 . LEU A 1 154 ? 116.184 114.617 87.303  1.00 127.51 ? 154 LEU A CD2 1 
ATOM   786  N N   . MET A 1 155 ? 117.044 110.317 90.266  1.00 69.27  ? 155 MET A N   1 
ATOM   787  C CA  . MET A 1 155 ? 117.872 109.887 91.381  1.00 73.51  ? 155 MET A CA  1 
ATOM   788  C C   . MET A 1 155 ? 118.915 108.861 90.930  1.00 74.04  ? 155 MET A C   1 
ATOM   789  O O   . MET A 1 155 ? 120.065 108.940 91.355  1.00 62.46  ? 155 MET A O   1 
ATOM   790  C CB  . MET A 1 155 ? 117.002 109.323 92.504  1.00 77.85  ? 155 MET A CB  1 
ATOM   791  C CG  . MET A 1 155 ? 116.168 110.388 93.160  1.00 72.11  ? 155 MET A CG  1 
ATOM   792  S SD  . MET A 1 155 ? 115.337 109.908 94.721  1.00 80.71  ? 155 MET A SD  1 
ATOM   793  C CE  . MET A 1 155 ? 114.149 108.707 94.148  1.00 102.71 ? 155 MET A CE  1 
ATOM   794  N N   . ALA A 1 156 ? 118.533 107.934 90.042  1.00 85.16  ? 156 ALA A N   1 
ATOM   795  C CA  . ALA A 1 156 ? 119.399 106.830 89.648  1.00 88.34  ? 156 ALA A CA  1 
ATOM   796  C C   . ALA A 1 156 ? 120.514 107.253 88.691  1.00 78.07  ? 156 ALA A C   1 
ATOM   797  O O   . ALA A 1 156 ? 121.486 106.518 88.531  1.00 80.91  ? 156 ALA A O   1 
ATOM   798  C CB  . ALA A 1 156 ? 118.555 105.730 89.037  1.00 114.67 ? 156 ALA A CB  1 
ATOM   799  N N   . CYS A 1 157 ? 120.374 108.418 88.039  1.00 75.00  ? 157 CYS A N   1 
ATOM   800  C CA  . CYS A 1 157 ? 121.402 108.959 87.160  1.00 96.26  ? 157 CYS A CA  1 
ATOM   801  C C   . CYS A 1 157 ? 122.323 109.958 87.865  1.00 98.34  ? 157 CYS A C   1 
ATOM   802  O O   . CYS A 1 157 ? 123.261 110.454 87.237  1.00 109.29 ? 157 CYS A O   1 
ATOM   803  C CB  . CYS A 1 157 ? 120.764 109.651 85.959  1.00 120.44 ? 157 CYS A CB  1 
ATOM   804  S SG  . CYS A 1 157 ? 119.777 108.522 84.940  1.00 145.79 ? 157 CYS A SG  1 
ATOM   805  N N   . SER A 1 158 ? 122.085 110.228 89.161  1.00 95.38  ? 158 SER A N   1 
ATOM   806  C CA  . SER A 1 158 ? 122.799 111.265 89.901  1.00 95.43  ? 158 SER A CA  1 
ATOM   807  C C   . SER A 1 158 ? 124.293 110.960 90.023  1.00 95.59  ? 158 SER A C   1 
ATOM   808  O O   . SER A 1 158 ? 125.096 111.871 90.089  1.00 86.49  ? 158 SER A O   1 
ATOM   809  C CB  . SER A 1 158 ? 122.190 111.470 91.268  1.00 106.81 ? 158 SER A CB  1 
ATOM   810  O OG  . SER A 1 158 ? 122.280 110.290 92.061  1.00 120.96 ? 158 SER A OG  1 
ATOM   811  N N   . LEU A 1 159 ? 124.684 109.680 90.042  1.00 98.71  ? 159 LEU A N   1 
ATOM   812  C CA  . LEU A 1 159 ? 126.087 109.310 90.131  1.00 104.24 ? 159 LEU A CA  1 
ATOM   813  C C   . LEU A 1 159 ? 126.798 109.534 88.785  1.00 119.93 ? 159 LEU A C   1 
ATOM   814  O O   . LEU A 1 159 ? 127.917 110.043 88.784  1.00 107.06 ? 159 LEU A O   1 
ATOM   815  C CB  . LEU A 1 159 ? 126.184 107.848 90.597  1.00 114.87 ? 159 LEU A CB  1 
ATOM   816  C CG  . LEU A 1 159 ? 127.613 107.334 90.771  1.00 124.31 ? 159 LEU A CG  1 
ATOM   817  C CD1 . LEU A 1 159 ? 128.315 108.054 91.912  1.00 89.10  ? 159 LEU A CD1 1 
ATOM   818  C CD2 . LEU A 1 159 ? 127.609 105.822 90.969  1.00 174.16 ? 159 LEU A CD2 1 
ATOM   819  N N   . GLN A 1 160 ? 126.170 109.184 87.645  1.00 121.10 ? 160 GLN A N   1 
ATOM   820  C CA  . GLN A 1 160 ? 126.783 109.388 86.336  1.00 115.73 ? 160 GLN A CA  1 
ATOM   821  C C   . GLN A 1 160 ? 126.926 110.876 86.006  1.00 116.19 ? 160 GLN A C   1 
ATOM   822  O O   . GLN A 1 160 ? 127.951 111.285 85.450  1.00 130.46 ? 160 GLN A O   1 
ATOM   823  C CB  . GLN A 1 160 ? 125.991 108.713 85.213  1.00 151.47 ? 160 GLN A CB  1 
ATOM   824  C CG  . GLN A 1 160 ? 126.035 107.186 85.233  1.00 215.37 ? 160 GLN A CG  1 
ATOM   825  C CD  . GLN A 1 160 ? 124.832 106.558 85.906  1.00 280.61 ? 160 GLN A CD  1 
ATOM   826  O OE1 . GLN A 1 160 ? 124.377 107.015 86.954  1.00 299.42 ? 160 GLN A OE1 1 
ATOM   827  N NE2 . GLN A 1 160 ? 124.288 105.508 85.300  1.00 292.57 ? 160 GLN A NE2 1 
ATOM   828  N N   . ALA A 1 161 ? 125.895 111.675 86.319  1.00 101.83 ? 161 ALA A N   1 
ATOM   829  C CA  . ALA A 1 161 ? 125.858 113.094 85.990  1.00 102.82 ? 161 ALA A CA  1 
ATOM   830  C C   . ALA A 1 161 ? 126.795 113.927 86.868  1.00 102.42 ? 161 ALA A C   1 
ATOM   831  O O   . ALA A 1 161 ? 127.218 115.009 86.469  1.00 123.22 ? 161 ALA A O   1 
ATOM   832  C CB  . ALA A 1 161 ? 124.438 113.592 86.085  1.00 115.16 ? 161 ALA A CB  1 
ATOM   833  N N   . GLY A 1 162 ? 127.078 113.463 88.090  1.00 124.26 ? 162 GLY A N   1 
ATOM   834  C CA  . GLY A 1 162 ? 128.093 114.075 88.941  1.00 145.40 ? 162 GLY A CA  1 
ATOM   835  C C   . GLY A 1 162 ? 127.578 115.216 89.815  1.00 119.23 ? 162 GLY A C   1 
ATOM   836  O O   . GLY A 1 162 ? 128.284 115.669 90.712  1.00 135.57 ? 162 GLY A O   1 
ATOM   837  N N   . ALA A 1 163 ? 126.346 115.673 89.560  1.00 89.35  ? 163 ALA A N   1 
ATOM   838  C CA  . ALA A 1 163 ? 125.727 116.765 90.295  1.00 92.80  ? 163 ALA A CA  1 
ATOM   839  C C   . ALA A 1 163 ? 124.802 116.238 91.382  1.00 78.53  ? 163 ALA A C   1 
ATOM   840  O O   . ALA A 1 163 ? 123.937 115.427 91.095  1.00 89.82  ? 163 ALA A O   1 
ATOM   841  C CB  . ALA A 1 163 ? 124.927 117.564 89.302  1.00 136.93 ? 163 ALA A CB  1 
ATOM   842  N N   . PHE A 1 164 ? 124.936 116.734 92.618  1.00 75.92  ? 164 PHE A N   1 
ATOM   843  C CA  . PHE A 1 164 ? 124.156 116.209 93.733  1.00 86.29  ? 164 PHE A CA  1 
ATOM   844  C C   . PHE A 1 164 ? 122.736 116.782 93.795  1.00 90.56  ? 164 PHE A C   1 
ATOM   845  O O   . PHE A 1 164 ? 121.893 116.257 94.525  1.00 86.39  ? 164 PHE A O   1 
ATOM   846  C CB  . PHE A 1 164 ? 124.907 116.397 95.053  1.00 106.09 ? 164 PHE A CB  1 
ATOM   847  C CG  . PHE A 1 164 ? 125.117 117.815 95.527  1.00 119.49 ? 164 PHE A CG  1 
ATOM   848  C CD1 . PHE A 1 164 ? 124.089 118.564 96.082  1.00 108.86 ? 164 PHE A CD1 1 
ATOM   849  C CD2 . PHE A 1 164 ? 126.382 118.380 95.472  1.00 128.01 ? 164 PHE A CD2 1 
ATOM   850  C CE1 . PHE A 1 164 ? 124.317 119.856 96.520  1.00 129.19 ? 164 PHE A CE1 1 
ATOM   851  C CE2 . PHE A 1 164 ? 126.612 119.672 95.922  1.00 140.01 ? 164 PHE A CE2 1 
ATOM   852  C CZ  . PHE A 1 164 ? 125.581 120.404 96.456  1.00 148.11 ? 164 PHE A CZ  1 
ATOM   853  N N   . GLU A 1 165 ? 122.444 117.832 93.003  1.00 110.41 ? 165 GLU A N   1 
ATOM   854  C CA  . GLU A 1 165 ? 121.122 118.431 92.968  1.00 96.60  ? 165 GLU A CA  1 
ATOM   855  C C   . GLU A 1 165 ? 120.106 117.390 92.503  1.00 71.41  ? 165 GLU A C   1 
ATOM   856  O O   . GLU A 1 165 ? 118.969 117.410 92.961  1.00 57.37  ? 165 GLU A O   1 
ATOM   857  C CB  . GLU A 1 165 ? 121.099 119.656 92.043  1.00 121.77 ? 165 GLU A CB  1 
ATOM   858  C CG  . GLU A 1 165 ? 121.705 120.896 92.675  1.00 161.43 ? 165 GLU A CG  1 
ATOM   859  C CD  . GLU A 1 165 ? 123.142 121.199 92.299  1.00 179.21 ? 165 GLU A CD  1 
ATOM   860  O OE1 . GLU A 1 165 ? 123.559 120.822 91.192  1.00 203.95 ? 165 GLU A OE1 1 
ATOM   861  O OE2 . GLU A 1 165 ? 123.840 121.844 93.106  1.00 180.51 ? 165 GLU A OE2 1 
ATOM   862  N N   . MET A 1 166 ? 120.464 116.535 91.536  1.00 74.23  ? 166 MET A N   1 
ATOM   863  C CA  . MET A 1 166 ? 119.520 115.607 90.948  1.00 86.61  ? 166 MET A CA  1 
ATOM   864  C C   . MET A 1 166 ? 118.970 114.641 91.985  1.00 82.97  ? 166 MET A C   1 
ATOM   865  O O   . MET A 1 166 ? 117.867 114.123 91.805  1.00 116.99 ? 166 MET A O   1 
ATOM   866  C CB  . MET A 1 166 ? 120.182 114.826 89.805  1.00 100.86 ? 166 MET A CB  1 
ATOM   867  C CG  . MET A 1 166 ? 120.116 115.531 88.482  1.00 110.36 ? 166 MET A CG  1 
ATOM   868  S SD  . MET A 1 166 ? 121.250 114.790 87.288  1.00 123.43 ? 166 MET A SD  1 
ATOM   869  C CE  . MET A 1 166 ? 120.434 113.230 86.989  1.00 101.58 ? 166 MET A CE  1 
ATOM   870  N N   . LEU A 1 167 ? 119.722 114.359 93.052  1.00 84.36  ? 167 LEU A N   1 
ATOM   871  C CA  . LEU A 1 167 ? 119.226 113.456 94.090  1.00 76.24  ? 167 LEU A CA  1 
ATOM   872  C C   . LEU A 1 167 ? 118.294 114.214 95.044  1.00 79.26  ? 167 LEU A C   1 
ATOM   873  O O   . LEU A 1 167 ? 117.246 113.698 95.397  1.00 91.54  ? 167 LEU A O   1 
ATOM   874  C CB  . LEU A 1 167 ? 120.418 112.815 94.803  1.00 63.46  ? 167 LEU A CB  1 
ATOM   875  C CG  . LEU A 1 167 ? 120.106 111.897 95.966  1.00 70.88  ? 167 LEU A CG  1 
ATOM   876  C CD1 . LEU A 1 167 ? 119.111 110.840 95.585  1.00 79.04  ? 167 LEU A CD1 1 
ATOM   877  C CD2 . LEU A 1 167 ? 121.401 111.262 96.456  1.00 93.49  ? 167 LEU A CD2 1 
ATOM   878  N N   . ILE A 1 168 ? 118.624 115.451 95.452  1.00 80.32  ? 168 ILE A N   1 
ATOM   879  C CA  . ILE A 1 168 ? 117.747 116.205 96.331  1.00 63.15  ? 168 ILE A CA  1 
ATOM   880  C C   . ILE A 1 168 ? 116.442 116.537 95.602  1.00 65.07  ? 168 ILE A C   1 
ATOM   881  O O   . ILE A 1 168 ? 115.367 116.374 96.174  1.00 80.73  ? 168 ILE A O   1 
ATOM   882  C CB  . ILE A 1 168 ? 118.463 117.453 96.888  1.00 63.95  ? 168 ILE A CB  1 
ATOM   883  C CG1 . ILE A 1 168 ? 119.734 117.066 97.642  1.00 71.36  ? 168 ILE A CG1 1 
ATOM   884  C CG2 . ILE A 1 168 ? 117.513 118.306 97.737  1.00 58.73  ? 168 ILE A CG2 1 
ATOM   885  C CD1 . ILE A 1 168 ? 120.588 118.222 98.100  1.00 93.12  ? 168 ILE A CD1 1 
ATOM   886  N N   . VAL A 1 169 ? 116.493 117.020 94.353  1.00 64.31  ? 169 VAL A N   1 
ATOM   887  C CA  . VAL A 1 169 ? 115.298 117.301 93.565  1.00 60.87  ? 169 VAL A CA  1 
ATOM   888  C C   . VAL A 1 169 ? 114.529 116.017 93.252  1.00 59.19  ? 169 VAL A C   1 
ATOM   889  O O   . VAL A 1 169 ? 113.310 116.020 93.214  1.00 74.86  ? 169 VAL A O   1 
ATOM   890  C CB  . VAL A 1 169 ? 115.643 118.085 92.286  1.00 74.32  ? 169 VAL A CB  1 
ATOM   891  C CG1 . VAL A 1 169 ? 114.487 118.156 91.285  1.00 84.76  ? 169 VAL A CG1 1 
ATOM   892  C CG2 . VAL A 1 169 ? 116.152 119.480 92.647  1.00 91.66  ? 169 VAL A CG2 1 
ATOM   893  N N   . GLY A 1 170 ? 115.236 114.904 93.041  1.00 78.83  ? 170 GLY A N   1 
ATOM   894  C CA  . GLY A 1 170 ? 114.610 113.615 92.834  1.00 81.17  ? 170 GLY A CA  1 
ATOM   895  C C   . GLY A 1 170 ? 113.781 113.177 94.041  1.00 60.66  ? 170 GLY A C   1 
ATOM   896  O O   . GLY A 1 170 ? 112.670 112.711 93.881  1.00 71.96  ? 170 GLY A O   1 
ATOM   897  N N   . ARG A 1 171 ? 114.299 113.360 95.259  1.00 46.68  ? 171 ARG A N   1 
ATOM   898  C CA  . ARG A 1 171 ? 113.571 113.047 96.468  1.00 44.93  ? 171 ARG A CA  1 
ATOM   899  C C   . ARG A 1 171 ? 112.336 113.923 96.609  1.00 53.96  ? 171 ARG A C   1 
ATOM   900  O O   . ARG A 1 171 ? 111.327 113.463 97.137  1.00 52.37  ? 171 ARG A O   1 
ATOM   901  C CB  . ARG A 1 171 ? 114.456 113.227 97.700  1.00 58.77  ? 171 ARG A CB  1 
ATOM   902  C CG  . ARG A 1 171 ? 115.493 112.144 97.895  1.00 73.96  ? 171 ARG A CG  1 
ATOM   903  C CD  . ARG A 1 171 ? 114.859 110.898 98.465  1.00 77.18  ? 171 ARG A CD  1 
ATOM   904  N NE  . ARG A 1 171 ? 114.531 111.037 99.879  1.00 74.13  ? 171 ARG A NE  1 
ATOM   905  C CZ  . ARG A 1 171 ? 113.988 110.070 100.603 1.00 73.38  ? 171 ARG A CZ  1 
ATOM   906  N NH1 . ARG A 1 171 ? 113.726 110.248 101.888 1.00 50.98  ? 171 ARG A NH1 1 
ATOM   907  N NH2 . ARG A 1 171 ? 113.708 108.923 100.005 1.00 85.80  ? 171 ARG A NH2 1 
ATOM   908  N N   . PHE A 1 172 ? 112.394 115.188 96.177  1.00 67.06  ? 172 PHE A N   1 
ATOM   909  C CA  . PHE A 1 172 ? 111.251 116.085 96.266  1.00 69.46  ? 172 PHE A CA  1 
ATOM   910  C C   . PHE A 1 172 ? 110.117 115.604 95.362  1.00 57.47  ? 172 PHE A C   1 
ATOM   911  O O   . PHE A 1 172 ? 108.999 115.428 95.835  1.00 70.14  ? 172 PHE A O   1 
ATOM   912  C CB  . PHE A 1 172 ? 111.648 117.529 95.941  1.00 74.99  ? 172 PHE A CB  1 
ATOM   913  C CG  . PHE A 1 172 ? 110.464 118.451 95.820  1.00 83.16  ? 172 PHE A CG  1 
ATOM   914  C CD1 . PHE A 1 172 ? 109.744 118.820 96.953  1.00 97.44  ? 172 PHE A CD1 1 
ATOM   915  C CD2 . PHE A 1 172 ? 110.037 118.893 94.581  1.00 85.17  ? 172 PHE A CD2 1 
ATOM   916  C CE1 . PHE A 1 172 ? 108.649 119.658 96.860  1.00 88.19  ? 172 PHE A CE1 1 
ATOM   917  C CE2 . PHE A 1 172 ? 108.913 119.687 94.483  1.00 115.04 ? 172 PHE A CE2 1 
ATOM   918  C CZ  . PHE A 1 172 ? 108.224 120.060 95.619  1.00 111.63 ? 172 PHE A CZ  1 
ATOM   919  N N   . ILE A 1 173 ? 110.391 115.369 94.076  1.00 57.48  ? 173 ILE A N   1 
ATOM   920  C CA  . ILE A 1 173 ? 109.371 114.936 93.131  1.00 61.92  ? 173 ILE A CA  1 
ATOM   921  C C   . ILE A 1 173 ? 108.853 113.528 93.491  1.00 50.78  ? 173 ILE A C   1 
ATOM   922  O O   . ILE A 1 173 ? 107.691 113.235 93.291  1.00 65.40  ? 173 ILE A O   1 
ATOM   923  C CB  . ILE A 1 173 ? 109.895 115.070 91.676  1.00 56.45  ? 173 ILE A CB  1 
ATOM   924  C CG1 . ILE A 1 173 ? 110.246 116.519 91.383  1.00 63.07  ? 173 ILE A CG1 1 
ATOM   925  C CG2 . ILE A 1 173 ? 108.906 114.554 90.662  1.00 65.96  ? 173 ILE A CG2 1 
ATOM   926  C CD1 . ILE A 1 173 ? 110.742 116.777 89.988  1.00 89.25  ? 173 ILE A CD1 1 
ATOM   927  N N   . MET A 1 174 ? 109.675 112.675 94.072  1.00 44.74  ? 174 MET A N   1 
ATOM   928  C CA  . MET A 1 174 ? 109.229 111.416 94.639  1.00 49.00  ? 174 MET A CA  1 
ATOM   929  C C   . MET A 1 174 ? 108.327 111.642 95.859  1.00 50.80  ? 174 MET A C   1 
ATOM   930  O O   . MET A 1 174 ? 107.441 110.843 96.148  1.00 55.24  ? 174 MET A O   1 
ATOM   931  C CB  . MET A 1 174 ? 110.444 110.583 95.078  1.00 68.65  ? 174 MET A CB  1 
ATOM   932  C CG  . MET A 1 174 ? 110.128 109.182 95.510  1.00 66.91  ? 174 MET A CG  1 
ATOM   933  S SD  . MET A 1 174 ? 109.367 108.236 94.205  1.00 98.75  ? 174 MET A SD  1 
ATOM   934  C CE  . MET A 1 174 ? 110.804 107.957 93.151  1.00 127.84 ? 174 MET A CE  1 
ATOM   935  N N   . GLY A 1 175 ? 108.530 112.731 96.591  1.00 58.03  ? 175 GLY A N   1 
ATOM   936  C CA  . GLY A 1 175 ? 107.617 113.124 97.656  1.00 59.73  ? 175 GLY A CA  1 
ATOM   937  C C   . GLY A 1 175 ? 106.251 113.546 97.129  1.00 56.35  ? 175 GLY A C   1 
ATOM   938  O O   . GLY A 1 175 ? 105.258 113.276 97.792  1.00 64.99  ? 175 GLY A O   1 
ATOM   939  N N   . ILE A 1 176 ? 106.187 114.206 95.960  1.00 47.05  ? 176 ILE A N   1 
ATOM   940  C CA  . ILE A 1 176 ? 104.919 114.604 95.371  1.00 50.40  ? 176 ILE A CA  1 
ATOM   941  C C   . ILE A 1 176 ? 104.046 113.364 95.131  1.00 69.34  ? 176 ILE A C   1 
ATOM   942  O O   . ILE A 1 176 ? 102.859 113.390 95.461  1.00 84.49  ? 176 ILE A O   1 
ATOM   943  C CB  . ILE A 1 176 ? 105.119 115.453 94.104  1.00 59.99  ? 176 ILE A CB  1 
ATOM   944  C CG1 . ILE A 1 176 ? 105.679 116.824 94.451  1.00 70.86  ? 176 ILE A CG1 1 
ATOM   945  C CG2 . ILE A 1 176 ? 103.824 115.610 93.339  1.00 75.77  ? 176 ILE A CG2 1 
ATOM   946  C CD1 . ILE A 1 176 ? 105.918 117.720 93.238  1.00 87.12  ? 176 ILE A CD1 1 
ATOM   947  N N   . ASP A 1 177 ? 104.618 112.273 94.596  1.00 65.33  ? 177 ASP A N   1 
ATOM   948  C CA  . ASP A 1 177 ? 103.927 110.999 94.480  1.00 73.60  ? 177 ASP A CA  1 
ATOM   949  C C   . ASP A 1 177 ? 103.393 110.522 95.845  1.00 79.02  ? 177 ASP A C   1 
ATOM   950  O O   . ASP A 1 177 ? 102.235 110.176 95.988  1.00 70.00  ? 177 ASP A O   1 
ATOM   951  C CB  . ASP A 1 177 ? 104.842 109.947 93.847  1.00 90.72  ? 177 ASP A CB  1 
ATOM   952  C CG  . ASP A 1 177 ? 104.427 108.515 94.199  1.00 126.93 ? 177 ASP A CG  1 
ATOM   953  O OD1 . ASP A 1 177 ? 103.428 108.040 93.633  1.00 131.55 ? 177 ASP A OD1 1 
ATOM   954  O OD2 . ASP A 1 177 ? 105.062 107.897 95.073  1.00 126.30 ? 177 ASP A OD2 1 
ATOM   955  N N   . GLY A 1 178 ? 104.239 110.490 96.877  1.00 87.10  ? 178 GLY A N   1 
ATOM   956  C CA  . GLY A 1 178 ? 103.816 110.046 98.195  1.00 96.40  ? 178 GLY A CA  1 
ATOM   957  C C   . GLY A 1 178 ? 102.714 110.899 98.820  1.00 92.10  ? 178 GLY A C   1 
ATOM   958  O O   . GLY A 1 178 ? 101.981 110.411 99.659  1.00 101.05 ? 178 GLY A O   1 
ATOM   959  N N   . GLY A 1 179 ? 102.620 112.179 98.431  1.00 76.31  ? 179 GLY A N   1 
ATOM   960  C CA  . GLY A 1 179 ? 101.571 113.068 98.898  1.00 76.56  ? 179 GLY A CA  1 
ATOM   961  C C   . GLY A 1 179 ? 100.264 112.896 98.130  1.00 82.38  ? 179 GLY A C   1 
ATOM   962  O O   . GLY A 1 179 ? 99.190  112.899 98.744  1.00 85.16  ? 179 GLY A O   1 
ATOM   963  N N   . VAL A 1 180 ? 100.369 112.733 96.792  1.00 83.69  ? 180 VAL A N   1 
ATOM   964  C CA  . VAL A 1 180 ? 99.230  112.527 95.908  1.00 70.66  ? 180 VAL A CA  1 
ATOM   965  C C   . VAL A 1 180 ? 98.607  111.159 96.138  1.00 63.04  ? 180 VAL A C   1 
ATOM   966  O O   . VAL A 1 180 ? 97.399  111.062 96.307  1.00 75.13  ? 180 VAL A O   1 
ATOM   967  C CB  . VAL A 1 180 ? 99.601  112.722 94.427  1.00 81.05  ? 180 VAL A CB  1 
ATOM   968  C CG1 . VAL A 1 180 ? 98.532  112.184 93.474  1.00 70.27  ? 180 VAL A CG1 1 
ATOM   969  C CG2 . VAL A 1 180 ? 99.889  114.190 94.118  1.00 102.42 ? 180 VAL A CG2 1 
ATOM   970  N N   . ALA A 1 181 ? 99.399  110.085 96.146  1.00 79.24  ? 181 ALA A N   1 
ATOM   971  C CA  . ALA A 1 181 ? 98.833  108.754 95.997  1.00 91.42  ? 181 ALA A CA  1 
ATOM   972  C C   . ALA A 1 181 ? 98.319  108.180 97.319  1.00 76.91  ? 181 ALA A C   1 
ATOM   973  O O   . ALA A 1 181 ? 97.408  107.351 97.283  1.00 100.90 ? 181 ALA A O   1 
ATOM   974  C CB  . ALA A 1 181 ? 99.828  107.866 95.305  1.00 101.66 ? 181 ALA A CB  1 
ATOM   975  N N   . LEU A 1 182 ? 98.818  108.652 98.468  1.00 80.13  ? 182 LEU A N   1 
ATOM   976  C CA  . LEU A 1 182 ? 98.238  108.300 99.762  1.00 88.01  ? 182 LEU A CA  1 
ATOM   977  C C   . LEU A 1 182 ? 96.892  108.982 99.991  1.00 85.42  ? 182 LEU A C   1 
ATOM   978  O O   . LEU A 1 182 ? 96.134  108.541 100.853 1.00 121.02 ? 182 LEU A O   1 
ATOM   979  C CB  . LEU A 1 182 ? 99.183  108.656 100.913 1.00 87.98  ? 182 LEU A CB  1 
ATOM   980  C CG  . LEU A 1 182 ? 100.319 107.660 101.182 1.00 98.98  ? 182 LEU A CG  1 
ATOM   981  C CD1 . LEU A 1 182 ? 101.106 108.091 102.409 1.00 79.61  ? 182 LEU A CD1 1 
ATOM   982  C CD2 . LEU A 1 182 ? 99.833  106.203 101.321 1.00 104.81 ? 182 LEU A CD2 1 
ATOM   983  N N   . SER A 1 183 ? 96.609  110.079 99.288  1.00 87.25  ? 183 SER A N   1 
ATOM   984  C CA  . SER A 1 183 ? 95.360  110.812 99.449  1.00 84.06  ? 183 SER A CA  1 
ATOM   985  C C   . SER A 1 183 ? 94.278  110.283 98.509  1.00 71.36  ? 183 SER A C   1 
ATOM   986  O O   . SER A 1 183 ? 93.098  110.505 98.769  1.00 102.58 ? 183 SER A O   1 
ATOM   987  C CB  . SER A 1 183 ? 95.585  112.302 99.247  1.00 102.83 ? 183 SER A CB  1 
ATOM   988  O OG  . SER A 1 183 ? 96.607  112.787 100.121 1.00 136.05 ? 183 SER A OG  1 
ATOM   989  N N   . VAL A 1 184 ? 94.663  109.597 97.422  1.00 68.59  ? 184 VAL A N   1 
ATOM   990  C CA  . VAL A 1 184 ? 93.717  109.093 96.431  1.00 75.56  ? 184 VAL A CA  1 
ATOM   991  C C   . VAL A 1 184 ? 93.447  107.604 96.636  1.00 83.55  ? 184 VAL A C   1 
ATOM   992  O O   . VAL A 1 184 ? 92.305  107.179 96.453  1.00 121.98 ? 184 VAL A O   1 
ATOM   993  C CB  . VAL A 1 184 ? 94.176  109.353 94.983  1.00 76.10  ? 184 VAL A CB  1 
ATOM   994  C CG1 . VAL A 1 184 ? 93.295  108.650 93.958  1.00 72.07  ? 184 VAL A CG1 1 
ATOM   995  C CG2 . VAL A 1 184 ? 94.224  110.837 94.704  1.00 86.65  ? 184 VAL A CG2 1 
ATOM   996  N N   . LEU A 1 185 ? 94.441  106.806 97.041  1.00 75.89  ? 185 LEU A N   1 
ATOM   997  C CA  . LEU A 1 185 ? 94.240  105.364 97.091  1.00 77.98  ? 185 LEU A CA  1 
ATOM   998  C C   . LEU A 1 185 ? 93.137  104.995 98.091  1.00 88.86  ? 185 LEU A C   1 
ATOM   999  O O   . LEU A 1 185 ? 92.263  104.208 97.723  1.00 116.85 ? 185 LEU A O   1 
ATOM   1000 C CB  . LEU A 1 185 ? 95.571  104.655 97.390  1.00 101.76 ? 185 LEU A CB  1 
ATOM   1001 C CG  . LEU A 1 185 ? 95.530  103.134 97.481  1.00 100.46 ? 185 LEU A CG  1 
ATOM   1002 C CD1 . LEU A 1 185 ? 95.315  102.526 96.112  1.00 102.05 ? 185 LEU A CD1 1 
ATOM   1003 C CD2 . LEU A 1 185 ? 96.823  102.619 98.094  1.00 113.61 ? 185 LEU A CD2 1 
ATOM   1004 N N   . PRO A 1 186 ? 93.087  105.485 99.364  1.00 89.68  ? 186 PRO A N   1 
ATOM   1005 C CA  . PRO A 1 186 ? 91.987  105.160 100.273 1.00 103.60 ? 186 PRO A CA  1 
ATOM   1006 C C   . PRO A 1 186 ? 90.592  105.478 99.736  1.00 102.47 ? 186 PRO A C   1 
ATOM   1007 O O   . PRO A 1 186 ? 89.657  104.711 99.955  1.00 104.98 ? 186 PRO A O   1 
ATOM   1008 C CB  . PRO A 1 186 ? 92.273  106.015 101.515 1.00 106.70 ? 186 PRO A CB  1 
ATOM   1009 C CG  . PRO A 1 186 ? 93.762  106.167 101.484 1.00 107.92 ? 186 PRO A CG  1 
ATOM   1010 C CD  . PRO A 1 186 ? 94.082  106.335 100.014 1.00 91.33  ? 186 PRO A CD  1 
ATOM   1011 N N   . MET A 1 187 ? 90.464  106.596 99.012  1.00 84.09  ? 187 MET A N   1 
ATOM   1012 C CA  . MET A 1 187 ? 89.194  107.001 98.446  1.00 88.20  ? 187 MET A CA  1 
ATOM   1013 C C   . MET A 1 187 ? 88.810  106.084 97.288  1.00 84.18  ? 187 MET A C   1 
ATOM   1014 O O   . MET A 1 187 ? 87.667  105.644 97.226  1.00 113.11 ? 187 MET A O   1 
ATOM   1015 C CB  . MET A 1 187 ? 89.250  108.465 98.012  1.00 107.16 ? 187 MET A CB  1 
ATOM   1016 C CG  . MET A 1 187 ? 89.294  109.404 99.214  1.00 136.39 ? 187 MET A CG  1 
ATOM   1017 S SD  . MET A 1 187 ? 89.598  111.133 98.779  1.00 220.30 ? 187 MET A SD  1 
ATOM   1018 C CE  . MET A 1 187 ? 90.088  111.782 100.381 1.00 240.91 ? 187 MET A CE  1 
ATOM   1019 N N   . TYR A 1 188 ? 89.755  105.730 96.414  1.00 91.43  ? 188 TYR A N   1 
ATOM   1020 C CA  . TYR A 1 188 ? 89.480  104.798 95.325  1.00 104.58 ? 188 TYR A CA  1 
ATOM   1021 C C   . TYR A 1 188 ? 89.010  103.448 95.881  1.00 126.05 ? 188 TYR A C   1 
ATOM   1022 O O   . TYR A 1 188 ? 87.957  102.952 95.474  1.00 178.32 ? 188 TYR A O   1 
ATOM   1023 C CB  . TYR A 1 188 ? 90.706  104.634 94.429  1.00 112.69 ? 188 TYR A CB  1 
ATOM   1024 C CG  . TYR A 1 188 ? 90.541  103.586 93.339  1.00 115.48 ? 188 TYR A CG  1 
ATOM   1025 C CD1 . TYR A 1 188 ? 89.541  103.710 92.379  1.00 107.50 ? 188 TYR A CD1 1 
ATOM   1026 C CD2 . TYR A 1 188 ? 91.375  102.466 93.278  1.00 117.06 ? 188 TYR A CD2 1 
ATOM   1027 C CE1 . TYR A 1 188 ? 89.377  102.763 91.376  1.00 99.77  ? 188 TYR A CE1 1 
ATOM   1028 C CE2 . TYR A 1 188 ? 91.207  101.509 92.291  1.00 113.14 ? 188 TYR A CE2 1 
ATOM   1029 C CZ  . TYR A 1 188 ? 90.223  101.667 91.328  1.00 114.20 ? 188 TYR A CZ  1 
ATOM   1030 O OH  . TYR A 1 188 ? 90.091  100.730 90.344  1.00 120.10 ? 188 TYR A OH  1 
ATOM   1031 N N   . LEU A 1 189 ? 89.757  102.857 96.827  1.00 103.10 ? 189 LEU A N   1 
ATOM   1032 C CA  . LEU A 1 189 ? 89.428  101.548 97.375  1.00 108.93 ? 189 LEU A CA  1 
ATOM   1033 C C   . LEU A 1 189 ? 88.058  101.561 98.066  1.00 128.85 ? 189 LEU A C   1 
ATOM   1034 O O   . LEU A 1 189 ? 87.259  100.649 97.859  1.00 112.84 ? 189 LEU A O   1 
ATOM   1035 C CB  . LEU A 1 189 ? 90.514  101.120 98.368  1.00 101.47 ? 189 LEU A CB  1 
ATOM   1036 C CG  . LEU A 1 189 ? 91.892  100.858 97.788  1.00 105.59 ? 189 LEU A CG  1 
ATOM   1037 C CD1 . LEU A 1 189 ? 92.896  100.610 98.914  1.00 100.82 ? 189 LEU A CD1 1 
ATOM   1038 C CD2 . LEU A 1 189 ? 91.848  99.693  96.807  1.00 120.47 ? 189 LEU A CD2 1 
ATOM   1039 N N   . SER A 1 190 ? 87.786  102.578 98.899  1.00 121.45 ? 190 SER A N   1 
ATOM   1040 C CA  . SER A 1 190 ? 86.541  102.644 99.649  1.00 126.35 ? 190 SER A CA  1 
ATOM   1041 C C   . SER A 1 190 ? 85.350  103.039 98.774  1.00 127.54 ? 190 SER A C   1 
ATOM   1042 O O   . SER A 1 190 ? 84.212  102.861 99.207  1.00 160.16 ? 190 SER A O   1 
ATOM   1043 C CB  . SER A 1 190 ? 86.662  103.548 100.856 1.00 125.81 ? 190 SER A CB  1 
ATOM   1044 O OG  . SER A 1 190 ? 86.979  104.879 100.487 1.00 121.41 ? 190 SER A OG  1 
ATOM   1045 N N   . GLU A 1 191 ? 85.582  103.555 97.554  1.00 107.88 ? 191 GLU A N   1 
ATOM   1046 C CA  . GLU A 1 191 ? 84.506  103.804 96.600  1.00 113.16 ? 191 GLU A CA  1 
ATOM   1047 C C   . GLU A 1 191 ? 84.149  102.546 95.798  1.00 102.59 ? 191 GLU A C   1 
ATOM   1048 O O   . GLU A 1 191 ? 82.977  102.376 95.461  1.00 106.49 ? 191 GLU A O   1 
ATOM   1049 C CB  . GLU A 1 191 ? 84.842  104.971 95.670  1.00 139.10 ? 191 GLU A CB  1 
ATOM   1050 C CG  . GLU A 1 191 ? 84.768  106.350 96.322  1.00 180.48 ? 191 GLU A CG  1 
ATOM   1051 C CD  . GLU A 1 191 ? 85.160  107.515 95.419  1.00 214.10 ? 191 GLU A CD  1 
ATOM   1052 O OE1 . GLU A 1 191 ? 85.274  107.293 94.196  1.00 196.23 ? 191 GLU A OE1 1 
ATOM   1053 O OE2 . GLU A 1 191 ? 85.379  108.637 95.933  1.00 256.30 ? 191 GLU A OE2 1 
ATOM   1054 N N   . ILE A 1 192 ? 85.113  101.661 95.474  1.00 119.81 ? 192 ILE A N   1 
ATOM   1055 C CA  . ILE A 1 192 ? 84.838  100.482 94.643  1.00 132.67 ? 192 ILE A CA  1 
ATOM   1056 C C   . ILE A 1 192 ? 84.268  99.318  95.459  1.00 141.69 ? 192 ILE A C   1 
ATOM   1057 O O   . ILE A 1 192 ? 83.528  98.505  94.899  1.00 162.55 ? 192 ILE A O   1 
ATOM   1058 C CB  . ILE A 1 192 ? 86.063  99.990  93.836  1.00 105.66 ? 192 ILE A CB  1 
ATOM   1059 C CG1 . ILE A 1 192 ? 87.222  99.534  94.724  1.00 111.68 ? 192 ILE A CG1 1 
ATOM   1060 C CG2 . ILE A 1 192 ? 86.498  101.038 92.821  1.00 136.31 ? 192 ILE A CG2 1 
ATOM   1061 C CD1 . ILE A 1 192 ? 88.376  98.894  93.995  1.00 135.56 ? 192 ILE A CD1 1 
ATOM   1062 N N   . SER A 1 193 ? 84.619  99.221  96.755  1.00 114.19 ? 193 SER A N   1 
ATOM   1063 C CA  . SER A 1 193 ? 84.435  97.991  97.526  1.00 104.69 ? 193 SER A CA  1 
ATOM   1064 C C   . SER A 1 193 ? 82.981  97.739  97.912  1.00 98.49  ? 193 SER A C   1 
ATOM   1065 O O   . SER A 1 193 ? 82.217  98.674  98.135  1.00 125.44 ? 193 SER A O   1 
ATOM   1066 C CB  . SER A 1 193 ? 85.270  98.017  98.760  1.00 110.36 ? 193 SER A CB  1 
ATOM   1067 O OG  . SER A 1 193 ? 86.640  98.095  98.418  1.00 146.84 ? 193 SER A OG  1 
ATOM   1068 N N   . PRO A 1 194 ? 82.556  96.471  98.103  1.00 110.77 ? 194 PRO A N   1 
ATOM   1069 C CA  . PRO A 1 194 ? 81.220  96.204  98.619  1.00 134.39 ? 194 PRO A CA  1 
ATOM   1070 C C   . PRO A 1 194 ? 81.146  96.875  99.984  1.00 143.51 ? 194 PRO A C   1 
ATOM   1071 O O   . PRO A 1 194 ? 82.178  97.097  100.608 1.00 147.92 ? 194 PRO A O   1 
ATOM   1072 C CB  . PRO A 1 194 ? 81.137  94.677  98.719  1.00 152.52 ? 194 PRO A CB  1 
ATOM   1073 C CG  . PRO A 1 194 ? 82.254  94.181  97.821  1.00 157.37 ? 194 PRO A CG  1 
ATOM   1074 C CD  . PRO A 1 194 ? 83.332  95.243  97.896  1.00 137.02 ? 194 PRO A CD  1 
ATOM   1075 N N   . LYS A 1 195 ? 79.935  97.156  100.459 1.00 149.20 ? 195 LYS A N   1 
ATOM   1076 C CA  . LYS A 1 195 ? 79.763  97.873  101.714 1.00 157.63 ? 195 LYS A CA  1 
ATOM   1077 C C   . LYS A 1 195 ? 79.982  96.936  102.905 1.00 164.74 ? 195 LYS A C   1 
ATOM   1078 O O   . LYS A 1 195 ? 79.506  97.213  104.004 1.00 176.52 ? 195 LYS A O   1 
ATOM   1079 C CB  . LYS A 1 195 ? 78.378  98.523  101.808 1.00 179.14 ? 195 LYS A CB  1 
ATOM   1080 C CG  . LYS A 1 195 ? 77.523  98.509  100.544 1.00 204.83 ? 195 LYS A CG  1 
ATOM   1081 C CD  . LYS A 1 195 ? 76.627  97.256  100.373 1.00 218.01 ? 195 LYS A CD  1 
ATOM   1082 C CE  . LYS A 1 195 ? 76.123  96.626  101.662 1.00 231.22 ? 195 LYS A CE  1 
ATOM   1083 N NZ  . LYS A 1 195 ? 74.722  97.012  101.985 1.00 229.64 ? 195 LYS A NZ  1 
ATOM   1084 N N   . GLU A 1 196 ? 80.703  95.825  102.692 1.00 169.45 ? 196 GLU A N   1 
ATOM   1085 C CA  . GLU A 1 196 ? 80.920  94.805  103.714 1.00 177.22 ? 196 GLU A CA  1 
ATOM   1086 C C   . GLU A 1 196 ? 82.356  94.832  104.233 1.00 142.63 ? 196 GLU A C   1 
ATOM   1087 O O   . GLU A 1 196 ? 82.623  94.282  105.299 1.00 153.88 ? 196 GLU A O   1 
ATOM   1088 C CB  . GLU A 1 196 ? 80.605  93.419  103.148 1.00 194.95 ? 196 GLU A CB  1 
ATOM   1089 C CG  . GLU A 1 196 ? 79.126  93.082  103.158 1.00 226.14 ? 196 GLU A CG  1 
ATOM   1090 C CD  . GLU A 1 196 ? 78.646  92.344  101.925 1.00 219.44 ? 196 GLU A CD  1 
ATOM   1091 O OE1 . GLU A 1 196 ? 79.490  91.750  101.227 1.00 223.76 ? 196 GLU A OE1 1 
ATOM   1092 O OE2 . GLU A 1 196 ? 77.426  92.378  101.660 1.00 206.00 ? 196 GLU A OE2 1 
ATOM   1093 N N   . ILE A 1 197 ? 83.277  95.447  103.482 1.00 128.44 ? 197 ILE A N   1 
ATOM   1094 C CA  . ILE A 1 197 ? 84.696  95.408  103.816 1.00 124.21 ? 197 ILE A CA  1 
ATOM   1095 C C   . ILE A 1 197 ? 85.290  96.814  103.799 1.00 112.97 ? 197 ILE A C   1 
ATOM   1096 O O   . ILE A 1 197 ? 86.482  96.973  104.059 1.00 92.74  ? 197 ILE A O   1 
ATOM   1097 C CB  . ILE A 1 197 ? 85.469  94.465  102.870 1.00 126.06 ? 197 ILE A CB  1 
ATOM   1098 C CG1 . ILE A 1 197 ? 84.832  94.419  101.478 1.00 138.21 ? 197 ILE A CG1 1 
ATOM   1099 C CG2 . ILE A 1 197 ? 85.611  93.072  103.476 1.00 142.11 ? 197 ILE A CG2 1 
ATOM   1100 C CD1 . ILE A 1 197 ? 85.111  93.161  100.717 1.00 138.13 ? 197 ILE A CD1 1 
ATOM   1101 N N   . ARG A 1 198 ? 84.474  97.841  103.537 1.00 122.74 ? 198 ARG A N   1 
ATOM   1102 C CA  . ARG A 1 198 ? 85.007  99.190  103.417 1.00 136.04 ? 198 ARG A CA  1 
ATOM   1103 C C   . ARG A 1 198 ? 85.828  99.572  104.650 1.00 162.82 ? 198 ARG A C   1 
ATOM   1104 O O   . ARG A 1 198 ? 86.631  100.505 104.580 1.00 187.09 ? 198 ARG A O   1 
ATOM   1105 C CB  . ARG A 1 198 ? 83.882  100.194 103.146 1.00 156.40 ? 198 ARG A CB  1 
ATOM   1106 C CG  . ARG A 1 198 ? 83.365  100.147 101.713 1.00 160.70 ? 198 ARG A CG  1 
ATOM   1107 C CD  . ARG A 1 198 ? 82.175  101.053 101.409 1.00 160.91 ? 198 ARG A CD  1 
ATOM   1108 N NE  . ARG A 1 198 ? 81.658  100.750 100.079 1.00 181.74 ? 198 ARG A NE  1 
ATOM   1109 C CZ  . ARG A 1 198 ? 80.464  101.095 99.595  1.00 219.79 ? 198 ARG A CZ  1 
ATOM   1110 N NH1 . ARG A 1 198 ? 80.060  100.598 98.437  1.00 232.93 ? 198 ARG A NH1 1 
ATOM   1111 N NH2 . ARG A 1 198 ? 79.659  101.892 100.278 1.00 229.08 ? 198 ARG A NH2 1 
ATOM   1112 N N   . GLY A 1 199 ? 85.632  98.856  105.771 1.00 187.53 ? 199 GLY A N   1 
ATOM   1113 C CA  . GLY A 1 199 ? 86.399  99.063  106.997 1.00 199.97 ? 199 GLY A CA  1 
ATOM   1114 C C   . GLY A 1 199 ? 87.731  98.309  107.025 1.00 163.66 ? 199 GLY A C   1 
ATOM   1115 O O   . GLY A 1 199 ? 88.668  98.766  107.680 1.00 183.71 ? 199 GLY A O   1 
ATOM   1116 N N   . SER A 1 200 ? 87.814  97.162  106.333 1.00 127.05 ? 200 SER A N   1 
ATOM   1117 C CA  . SER A 1 200 ? 88.980  96.291  106.388 1.00 135.98 ? 200 SER A CA  1 
ATOM   1118 C C   . SER A 1 200 ? 90.136  96.817  105.538 1.00 135.34 ? 200 SER A C   1 
ATOM   1119 O O   . SER A 1 200 ? 91.294  96.611  105.900 1.00 148.84 ? 200 SER A O   1 
ATOM   1120 C CB  . SER A 1 200 ? 88.622  94.881  105.980 1.00 145.01 ? 200 SER A CB  1 
ATOM   1121 O OG  . SER A 1 200 ? 87.699  94.314  106.895 1.00 167.57 ? 200 SER A OG  1 
ATOM   1122 N N   . LEU A 1 201 ? 89.838  97.462  104.402 1.00 131.29 ? 201 LEU A N   1 
ATOM   1123 C CA  . LEU A 1 201 ? 90.880  97.850  103.457 1.00 124.99 ? 201 LEU A CA  1 
ATOM   1124 C C   . LEU A 1 201 ? 91.761  98.979  104.014 1.00 118.30 ? 201 LEU A C   1 
ATOM   1125 O O   . LEU A 1 201 ? 92.831  99.250  103.466 1.00 125.14 ? 201 LEU A O   1 
ATOM   1126 C CB  . LEU A 1 201 ? 90.245  98.222  102.109 1.00 112.99 ? 201 LEU A CB  1 
ATOM   1127 C CG  . LEU A 1 201 ? 89.529  97.080  101.369 1.00 118.12 ? 201 LEU A CG  1 
ATOM   1128 C CD1 . LEU A 1 201 ? 89.206  97.483  99.946  1.00 121.79 ? 201 LEU A CD1 1 
ATOM   1129 C CD2 . LEU A 1 201 ? 90.320  95.771  101.338 1.00 115.29 ? 201 LEU A CD2 1 
ATOM   1130 N N   . GLY A 1 202 ? 91.359  99.599  105.130 1.00 122.91 ? 202 GLY A N   1 
ATOM   1131 C CA  . GLY A 1 202 ? 92.240  100.496 105.872 1.00 150.47 ? 202 GLY A CA  1 
ATOM   1132 C C   . GLY A 1 202 ? 93.472  99.796  106.458 1.00 142.33 ? 202 GLY A C   1 
ATOM   1133 O O   . GLY A 1 202 ? 94.446  100.458 106.816 1.00 133.79 ? 202 GLY A O   1 
ATOM   1134 N N   . GLN A 1 203 ? 93.422  98.460  106.563 1.00 134.57 ? 203 GLN A N   1 
ATOM   1135 C CA  . GLN A 1 203 ? 94.580  97.658  106.927 1.00 136.68 ? 203 GLN A CA  1 
ATOM   1136 C C   . GLN A 1 203 ? 95.394  97.295  105.676 1.00 136.82 ? 203 GLN A C   1 
ATOM   1137 O O   . GLN A 1 203 ? 96.612  97.151  105.780 1.00 143.74 ? 203 GLN A O   1 
ATOM   1138 C CB  . GLN A 1 203 ? 94.142  96.413  107.704 1.00 170.43 ? 203 GLN A CB  1 
ATOM   1139 C CG  . GLN A 1 203 ? 95.281  95.738  108.456 1.00 217.24 ? 203 GLN A CG  1 
ATOM   1140 C CD  . GLN A 1 203 ? 94.901  94.423  109.102 1.00 234.77 ? 203 GLN A CD  1 
ATOM   1141 O OE1 . GLN A 1 203 ? 93.780  93.932  108.970 1.00 197.97 ? 203 GLN A OE1 1 
ATOM   1142 N NE2 . GLN A 1 203 ? 95.853  93.823  109.808 1.00 271.34 ? 203 GLN A NE2 1 
ATOM   1143 N N   . VAL A 1 204 ? 94.749  97.185  104.499 1.00 131.61 ? 204 VAL A N   1 
ATOM   1144 C CA  . VAL A 1 204 ? 95.422  96.848  103.247 1.00 129.94 ? 204 VAL A CA  1 
ATOM   1145 C C   . VAL A 1 204 ? 96.235  98.027  102.698 1.00 115.50 ? 204 VAL A C   1 
ATOM   1146 O O   . VAL A 1 204 ? 97.293  97.807  102.118 1.00 111.64 ? 204 VAL A O   1 
ATOM   1147 C CB  . VAL A 1 204 ? 94.426  96.311  102.202 1.00 142.57 ? 204 VAL A CB  1 
ATOM   1148 C CG1 . VAL A 1 204 ? 94.991  96.268  100.773 1.00 118.04 ? 204 VAL A CG1 1 
ATOM   1149 C CG2 . VAL A 1 204 ? 93.874  94.958  102.656 1.00 170.77 ? 204 VAL A CG2 1 
ATOM   1150 N N   . THR A 1 205 ? 95.799  99.281  102.904 1.00 122.32 ? 205 THR A N   1 
ATOM   1151 C CA  . THR A 1 205 ? 96.650  100.406 102.538 1.00 120.84 ? 205 THR A CA  1 
ATOM   1152 C C   . THR A 1 205 ? 97.880  100.481 103.442 1.00 108.62 ? 205 THR A C   1 
ATOM   1153 O O   . THR A 1 205 ? 98.921  100.946 102.989 1.00 131.23 ? 205 THR A O   1 
ATOM   1154 C CB  . THR A 1 205 ? 95.926  101.759 102.592 1.00 178.10 ? 205 THR A CB  1 
ATOM   1155 O OG1 . THR A 1 205 ? 95.446  101.992 103.919 1.00 196.67 ? 205 THR A OG1 1 
ATOM   1156 C CG2 . THR A 1 205 ? 94.787  101.850 101.597 1.00 224.49 ? 205 THR A CG2 1 
ATOM   1157 N N   . ALA A 1 206 ? 97.761  100.012 104.700 1.00 105.70 ? 206 ALA A N   1 
ATOM   1158 C CA  . ALA A 1 206 ? 98.807  100.121 105.716 1.00 85.83  ? 206 ALA A CA  1 
ATOM   1159 C C   . ALA A 1 206 ? 99.828  98.987  105.626 1.00 82.42  ? 206 ALA A C   1 
ATOM   1160 O O   . ALA A 1 206 ? 101.036 99.262  105.719 1.00 112.56 ? 206 ALA A O   1 
ATOM   1161 C CB  . ALA A 1 206 ? 98.196  100.180 107.088 1.00 99.76  ? 206 ALA A CB  1 
ATOM   1162 N N   . ILE A 1 207 ? 99.381  97.732  105.420 1.00 73.54  ? 207 ILE A N   1 
ATOM   1163 C CA  . ILE A 1 207 ? 100.304 96.612  105.288 1.00 78.67  ? 207 ILE A CA  1 
ATOM   1164 C C   . ILE A 1 207 ? 101.244 96.845  104.100 1.00 78.10  ? 207 ILE A C   1 
ATOM   1165 O O   . ILE A 1 207 ? 102.426 96.497  104.183 1.00 108.12 ? 207 ILE A O   1 
ATOM   1166 C CB  . ILE A 1 207 ? 99.562  95.264  105.210 1.00 86.25  ? 207 ILE A CB  1 
ATOM   1167 C CG1 . ILE A 1 207 ? 99.007  94.885  106.586 1.00 110.84 ? 207 ILE A CG1 1 
ATOM   1168 C CG2 . ILE A 1 207 ? 100.437 94.154  104.638 1.00 83.37  ? 207 ILE A CG2 1 
ATOM   1169 C CD1 . ILE A 1 207 ? 97.947  93.803  106.554 1.00 133.90 ? 207 ILE A CD1 1 
ATOM   1170 N N   . PHE A 1 208 ? 100.766 97.466  103.018 1.00 60.83  ? 208 PHE A N   1 
ATOM   1171 C CA  . PHE A 1 208 ? 101.655 97.727  101.904 1.00 75.25  ? 208 PHE A CA  1 
ATOM   1172 C C   . PHE A 1 208 ? 102.651 98.853  102.208 1.00 70.80  ? 208 PHE A C   1 
ATOM   1173 O O   . PHE A 1 208 ? 103.694 98.895  101.563 1.00 95.60  ? 208 PHE A O   1 
ATOM   1174 C CB  . PHE A 1 208 ? 100.848 97.955  100.625 1.00 100.11 ? 208 PHE A CB  1 
ATOM   1175 C CG  . PHE A 1 208 ? 100.615 96.679  99.861  1.00 80.89  ? 208 PHE A CG  1 
ATOM   1176 C CD1 . PHE A 1 208 ? 101.561 96.223  98.976  1.00 96.88  ? 208 PHE A CD1 1 
ATOM   1177 C CD2 . PHE A 1 208 ? 99.473  95.937  100.050 1.00 83.72  ? 208 PHE A CD2 1 
ATOM   1178 C CE1 . PHE A 1 208 ? 101.361 95.056  98.260  1.00 114.65 ? 208 PHE A CE1 1 
ATOM   1179 C CE2 . PHE A 1 208 ? 99.257  94.781  99.326  1.00 104.29 ? 208 PHE A CE2 1 
ATOM   1180 C CZ  . PHE A 1 208 ? 100.205 94.347  98.435  1.00 128.26 ? 208 PHE A CZ  1 
ATOM   1181 N N   . ILE A 1 209 ? 102.413 99.737  103.182 1.00 60.66  ? 209 ILE A N   1 
ATOM   1182 C CA  . ILE A 1 209 ? 103.491 100.611 103.632 1.00 61.11  ? 209 ILE A CA  1 
ATOM   1183 C C   . ILE A 1 209 ? 104.568 99.755  104.283 1.00 68.05  ? 209 ILE A C   1 
ATOM   1184 O O   . ILE A 1 209 ? 105.744 99.889  103.949 1.00 92.00  ? 209 ILE A O   1 
ATOM   1185 C CB  . ILE A 1 209 ? 103.039 101.751 104.566 1.00 63.68  ? 209 ILE A CB  1 
ATOM   1186 C CG1 . ILE A 1 209 ? 101.977 102.643 103.919 1.00 68.39  ? 209 ILE A CG1 1 
ATOM   1187 C CG2 . ILE A 1 209 ? 104.230 102.562 105.049 1.00 56.19  ? 209 ILE A CG2 1 
ATOM   1188 C CD1 . ILE A 1 209 ? 101.426 103.718 104.841 1.00 95.76  ? 209 ILE A CD1 1 
ATOM   1189 N N   . CYS A 1 210 ? 104.183 98.847  105.191 1.00 72.10  ? 210 CYS A N   1 
ATOM   1190 C CA  . CYS A 1 210 ? 105.151 98.054  105.938 1.00 82.94  ? 210 CYS A CA  1 
ATOM   1191 C C   . CYS A 1 210 ? 105.961 97.134  105.018 1.00 71.19  ? 210 CYS A C   1 
ATOM   1192 O O   . CYS A 1 210 ? 107.178 97.038  105.178 1.00 82.39  ? 210 CYS A O   1 
ATOM   1193 C CB  . CYS A 1 210 ? 104.416 97.272  107.009 1.00 102.37 ? 210 CYS A CB  1 
ATOM   1194 S SG  . CYS A 1 210 ? 103.444 98.378  108.065 1.00 118.56 ? 210 CYS A SG  1 
ATOM   1195 N N   . ILE A 1 211 ? 105.321 96.457  104.056 1.00 59.34  ? 211 ILE A N   1 
ATOM   1196 C CA  . ILE A 1 211 ? 106.049 95.645  103.099 1.00 59.35  ? 211 ILE A CA  1 
ATOM   1197 C C   . ILE A 1 211 ? 106.941 96.538  102.224 1.00 64.93  ? 211 ILE A C   1 
ATOM   1198 O O   . ILE A 1 211 ? 107.974 96.097  101.722 1.00 79.16  ? 211 ILE A O   1 
ATOM   1199 C CB  . ILE A 1 211 ? 105.066 94.763  102.305 1.00 66.97  ? 211 ILE A CB  1 
ATOM   1200 C CG1 . ILE A 1 211 ? 104.392 93.756  103.225 1.00 86.25  ? 211 ILE A CG1 1 
ATOM   1201 C CG2 . ILE A 1 211 ? 105.736 94.066  101.133 1.00 64.60  ? 211 ILE A CG2 1 
ATOM   1202 C CD1 . ILE A 1 211 ? 103.297 92.942  102.563 1.00 124.55 ? 211 ILE A CD1 1 
ATOM   1203 N N   . GLY A 1 212 ? 106.597 97.822  102.088 1.00 66.30  ? 212 GLY A N   1 
ATOM   1204 C CA  . GLY A 1 212 ? 107.502 98.835  101.551 1.00 61.42  ? 212 GLY A CA  1 
ATOM   1205 C C   . GLY A 1 212 ? 108.747 99.035  102.408 1.00 58.81  ? 212 GLY A C   1 
ATOM   1206 O O   . GLY A 1 212 ? 109.847 98.835  101.901 1.00 61.85  ? 212 GLY A O   1 
ATOM   1207 N N   . VAL A 1 213 ? 108.590 99.405  103.702 1.00 57.45  ? 213 VAL A N   1 
ATOM   1208 C CA  . VAL A 1 213 ? 109.741 99.721  104.551 1.00 53.29  ? 213 VAL A CA  1 
ATOM   1209 C C   . VAL A 1 213 ? 110.639 98.495  104.695 1.00 60.17  ? 213 VAL A C   1 
ATOM   1210 O O   . VAL A 1 213 ? 111.843 98.670  104.813 1.00 80.89  ? 213 VAL A O   1 
ATOM   1211 C CB  . VAL A 1 213 ? 109.419 100.322 105.935 1.00 54.67  ? 213 VAL A CB  1 
ATOM   1212 C CG1 . VAL A 1 213 ? 108.249 101.292 105.906 1.00 54.42  ? 213 VAL A CG1 1 
ATOM   1213 C CG2 . VAL A 1 213 ? 109.214 99.275  107.018 1.00 79.64  ? 213 VAL A CG2 1 
ATOM   1214 N N   . PHE A 1 214 ? 110.070 97.281  104.664 1.00 57.57  ? 214 PHE A N   1 
ATOM   1215 C CA  . PHE A 1 214 ? 110.826 96.040  104.718 1.00 57.42  ? 214 PHE A CA  1 
ATOM   1216 C C   . PHE A 1 214 ? 111.594 95.807  103.426 1.00 60.58  ? 214 PHE A C   1 
ATOM   1217 O O   . PHE A 1 214 ? 112.788 95.496  103.481 1.00 103.89 ? 214 PHE A O   1 
ATOM   1218 C CB  . PHE A 1 214 ? 109.916 94.851  105.021 1.00 70.18  ? 214 PHE A CB  1 
ATOM   1219 C CG  . PHE A 1 214 ? 110.615 93.515  104.993 1.00 79.56  ? 214 PHE A CG  1 
ATOM   1220 C CD1 . PHE A 1 214 ? 111.368 93.080  106.066 1.00 77.51  ? 214 PHE A CD1 1 
ATOM   1221 C CD2 . PHE A 1 214 ? 110.552 92.702  103.869 1.00 104.77 ? 214 PHE A CD2 1 
ATOM   1222 C CE1 . PHE A 1 214 ? 112.008 91.853  106.033 1.00 82.86  ? 214 PHE A CE1 1 
ATOM   1223 C CE2 . PHE A 1 214 ? 111.258 91.514  103.811 1.00 115.91 ? 214 PHE A CE2 1 
ATOM   1224 C CZ  . PHE A 1 214 ? 111.944 91.070  104.908 1.00 96.31  ? 214 PHE A CZ  1 
ATOM   1225 N N   . THR A 1 215 ? 110.960 95.957  102.256 1.00 67.17  ? 215 THR A N   1 
ATOM   1226 C CA  . THR A 1 215 ? 111.670 95.717  100.999 1.00 72.90  ? 215 THR A CA  1 
ATOM   1227 C C   . THR A 1 215 ? 112.856 96.684  100.840 1.00 75.16  ? 215 THR A C   1 
ATOM   1228 O O   . THR A 1 215 ? 113.920 96.261  100.429 1.00 61.62  ? 215 THR A O   1 
ATOM   1229 C CB  . THR A 1 215 ? 110.766 95.821  99.770  1.00 77.76  ? 215 THR A CB  1 
ATOM   1230 O OG1 . THR A 1 215 ? 109.676 94.924  99.935  1.00 92.54  ? 215 THR A OG1 1 
ATOM   1231 C CG2 . THR A 1 215 ? 111.492 95.479  98.490  1.00 98.13  ? 215 THR A CG2 1 
ATOM   1232 N N   . GLY A 1 216 ? 112.685 97.960  101.215 1.00 71.64  ? 216 GLY A N   1 
ATOM   1233 C CA  . GLY A 1 216 ? 113.779 98.913  101.210 1.00 70.89  ? 216 GLY A CA  1 
ATOM   1234 C C   . GLY A 1 216 ? 114.947 98.519  102.120 1.00 73.02  ? 216 GLY A C   1 
ATOM   1235 O O   . GLY A 1 216 ? 116.077 98.904  101.858 1.00 92.03  ? 216 GLY A O   1 
ATOM   1236 N N   . GLN A 1 217 ? 114.665 97.794  103.200 1.00 69.61  ? 217 GLN A N   1 
ATOM   1237 C CA  . GLN A 1 217 ? 115.693 97.307  104.109 1.00 78.58  ? 217 GLN A CA  1 
ATOM   1238 C C   . GLN A 1 217 ? 116.309 95.996  103.626 1.00 72.40  ? 217 GLN A C   1 
ATOM   1239 O O   . GLN A 1 217 ? 117.436 95.688  104.018 1.00 87.55  ? 217 GLN A O   1 
ATOM   1240 C CB  . GLN A 1 217 ? 115.117 97.107  105.520 1.00 76.12  ? 217 GLN A CB  1 
ATOM   1241 C CG  . GLN A 1 217 ? 114.915 98.409  106.252 1.00 92.49  ? 217 GLN A CG  1 
ATOM   1242 C CD  . GLN A 1 217 ? 114.365 98.222  107.638 1.00 90.04  ? 217 GLN A CD  1 
ATOM   1243 O OE1 . GLN A 1 217 ? 113.827 97.176  107.975 1.00 84.14  ? 217 GLN A OE1 1 
ATOM   1244 N NE2 . GLN A 1 217 ? 114.491 99.260  108.455 1.00 102.05 ? 217 GLN A NE2 1 
ATOM   1245 N N   . LEU A 1 218 ? 115.592 95.219  102.806 1.00 66.69  ? 218 LEU A N   1 
ATOM   1246 C CA  . LEU A 1 218 ? 116.129 93.985  102.255 1.00 76.22  ? 218 LEU A CA  1 
ATOM   1247 C C   . LEU A 1 218 ? 117.130 94.296  101.134 1.00 92.49  ? 218 LEU A C   1 
ATOM   1248 O O   . LEU A 1 218 ? 118.264 93.836  101.188 1.00 97.93  ? 218 LEU A O   1 
ATOM   1249 C CB  . LEU A 1 218 ? 114.980 93.114  101.743 1.00 81.41  ? 218 LEU A CB  1 
ATOM   1250 C CG  . LEU A 1 218 ? 115.420 91.742  101.246 1.00 83.63  ? 218 LEU A CG  1 
ATOM   1251 C CD1 . LEU A 1 218 ? 115.683 90.887  102.456 1.00 83.79  ? 218 LEU A CD1 1 
ATOM   1252 C CD2 . LEU A 1 218 ? 114.446 91.132  100.244 1.00 110.90 ? 218 LEU A CD2 1 
ATOM   1253 N N   . LEU A 1 219 ? 116.750 95.090  100.117 1.00 79.63  ? 219 LEU A N   1 
ATOM   1254 C CA  . LEU A 1 219 ? 117.631 95.344  98.988  1.00 69.79  ? 219 LEU A CA  1 
ATOM   1255 C C   . LEU A 1 219 ? 118.911 96.065  99.413  1.00 73.08  ? 219 LEU A C   1 
ATOM   1256 O O   . LEU A 1 219 ? 119.915 95.995  98.700  1.00 89.52  ? 219 LEU A O   1 
ATOM   1257 C CB  . LEU A 1 219 ? 116.891 96.153  97.917  1.00 74.50  ? 219 LEU A CB  1 
ATOM   1258 C CG  . LEU A 1 219 ? 115.651 95.534  97.291  1.00 76.56  ? 219 LEU A CG  1 
ATOM   1259 C CD1 . LEU A 1 219 ? 115.154 96.393  96.157  1.00 79.71  ? 219 LEU A CD1 1 
ATOM   1260 C CD2 . LEU A 1 219 ? 115.933 94.158  96.779  1.00 89.08  ? 219 LEU A CD2 1 
ATOM   1261 N N   . GLY A 1 220 ? 118.892 96.748  100.560 1.00 67.65  ? 220 GLY A N   1 
ATOM   1262 C CA  . GLY A 1 220 ? 120.057 97.445  101.099 1.00 71.97  ? 220 GLY A CA  1 
ATOM   1263 C C   . GLY A 1 220 ? 121.081 96.546  101.815 1.00 75.78  ? 220 GLY A C   1 
ATOM   1264 O O   . GLY A 1 220 ? 122.121 97.050  102.235 1.00 80.64  ? 220 GLY A O   1 
ATOM   1265 N N   . LEU A 1 221 ? 120.836 95.234  101.963 1.00 71.96  ? 221 LEU A N   1 
ATOM   1266 C CA  . LEU A 1 221 ? 121.859 94.324  102.468 1.00 78.19  ? 221 LEU A CA  1 
ATOM   1267 C C   . LEU A 1 221 ? 123.060 94.343  101.527 1.00 82.16  ? 221 LEU A C   1 
ATOM   1268 O O   . LEU A 1 221 ? 122.885 94.413  100.317 1.00 96.26  ? 221 LEU A O   1 
ATOM   1269 C CB  . LEU A 1 221 ? 121.314 92.894  102.516 1.00 82.81  ? 221 LEU A CB  1 
ATOM   1270 C CG  . LEU A 1 221 ? 120.280 92.555  103.584 1.00 86.69  ? 221 LEU A CG  1 
ATOM   1271 C CD1 . LEU A 1 221 ? 119.854 91.104  103.418 1.00 98.22  ? 221 LEU A CD1 1 
ATOM   1272 C CD2 . LEU A 1 221 ? 120.811 92.810  104.982 1.00 84.75  ? 221 LEU A CD2 1 
ATOM   1273 N N   . PRO A 1 222 ? 124.318 94.213  102.012 1.00 89.30  ? 222 PRO A N   1 
ATOM   1274 C CA  . PRO A 1 222 ? 125.474 94.214  101.119 1.00 104.62 ? 222 PRO A CA  1 
ATOM   1275 C C   . PRO A 1 222 ? 125.586 92.983  100.205 1.00 110.63 ? 222 PRO A C   1 
ATOM   1276 O O   . PRO A 1 222 ? 126.392 93.003  99.271  1.00 127.44 ? 222 PRO A O   1 
ATOM   1277 C CB  . PRO A 1 222 ? 126.666 94.336  102.092 1.00 117.24 ? 222 PRO A CB  1 
ATOM   1278 C CG  . PRO A 1 222 ? 126.165 93.752  103.389 1.00 109.32 ? 222 PRO A CG  1 
ATOM   1279 C CD  . PRO A 1 222 ? 124.690 94.094  103.428 1.00 97.96  ? 222 PRO A CD  1 
ATOM   1280 N N   . GLU A 1 223 ? 124.764 91.936  100.420 1.00 93.52  ? 223 GLU A N   1 
ATOM   1281 C CA  . GLU A 1 223 ? 124.610 90.845  99.467  1.00 102.05 ? 223 GLU A CA  1 
ATOM   1282 C C   . GLU A 1 223 ? 123.854 91.279  98.201  1.00 108.23 ? 223 GLU A C   1 
ATOM   1283 O O   . GLU A 1 223 ? 124.054 90.690  97.132  1.00 128.93 ? 223 GLU A O   1 
ATOM   1284 C CB  . GLU A 1 223 ? 123.851 89.677  100.103 1.00 120.02 ? 223 GLU A CB  1 
ATOM   1285 C CG  . GLU A 1 223 ? 124.696 88.784  101.000 1.00 171.30 ? 223 GLU A CG  1 
ATOM   1286 C CD  . GLU A 1 223 ? 124.808 89.187  102.463 1.00 207.62 ? 223 GLU A CD  1 
ATOM   1287 O OE1 . GLU A 1 223 ? 124.560 90.358  102.780 1.00 192.56 ? 223 GLU A OE1 1 
ATOM   1288 O OE2 . GLU A 1 223 ? 125.124 88.307  103.295 1.00 248.14 ? 223 GLU A OE2 1 
ATOM   1289 N N   . LEU A 1 224 ? 122.947 92.262  98.319  1.00 98.04  ? 224 LEU A N   1 
ATOM   1290 C CA  . LEU A 1 224 ? 122.116 92.693  97.197  1.00 88.79  ? 224 LEU A CA  1 
ATOM   1291 C C   . LEU A 1 224 ? 122.617 94.045  96.657  1.00 97.39  ? 224 LEU A C   1 
ATOM   1292 O O   . LEU A 1 224 ? 123.785 94.144  96.283  1.00 114.48 ? 224 LEU A O   1 
ATOM   1293 C CB  . LEU A 1 224 ? 120.647 92.718  97.652  1.00 74.18  ? 224 LEU A CB  1 
ATOM   1294 C CG  . LEU A 1 224 ? 120.058 91.347  97.963  1.00 74.66  ? 224 LEU A CG  1 
ATOM   1295 C CD1 . LEU A 1 224 ? 118.639 91.457  98.475  1.00 83.08  ? 224 LEU A CD1 1 
ATOM   1296 C CD2 . LEU A 1 224 ? 120.078 90.456  96.738  1.00 92.95  ? 224 LEU A CD2 1 
ATOM   1297 N N   . LEU A 1 225 ? 121.750 95.073  96.573  1.00 69.27  ? 225 LEU A N   1 
ATOM   1298 C CA  . LEU A 1 225 ? 122.084 96.291  95.860  1.00 73.79  ? 225 LEU A CA  1 
ATOM   1299 C C   . LEU A 1 225 ? 122.825 97.299  96.748  1.00 73.79  ? 225 LEU A C   1 
ATOM   1300 O O   . LEU A 1 225 ? 123.313 98.306  96.239  1.00 84.64  ? 225 LEU A O   1 
ATOM   1301 C CB  . LEU A 1 225 ? 120.789 96.899  95.298  1.00 97.16  ? 225 LEU A CB  1 
ATOM   1302 C CG  . LEU A 1 225 ? 120.348 96.404  93.924  1.00 97.54  ? 225 LEU A CG  1 
ATOM   1303 C CD1 . LEU A 1 225 ? 120.074 94.912  93.921  1.00 132.71 ? 225 LEU A CD1 1 
ATOM   1304 C CD2 . LEU A 1 225 ? 119.102 97.138  93.488  1.00 93.08  ? 225 LEU A CD2 1 
ATOM   1305 N N   . GLY A 1 226 ? 122.967 97.038  98.047  1.00 75.83  ? 226 GLY A N   1 
ATOM   1306 C CA  . GLY A 1 226 ? 123.563 97.990  98.978  1.00 92.36  ? 226 GLY A CA  1 
ATOM   1307 C C   . GLY A 1 226 ? 125.100 98.013  99.016  1.00 103.64 ? 226 GLY A C   1 
ATOM   1308 O O   . GLY A 1 226 ? 125.683 98.587  99.936  1.00 124.23 ? 226 GLY A O   1 
ATOM   1309 N N   . LYS A 1 227 ? 125.771 97.482  97.984  1.00 109.32 ? 227 LYS A N   1 
ATOM   1310 C CA  . LYS A 1 227 ? 127.218 97.602  97.804  1.00 111.87 ? 227 LYS A CA  1 
ATOM   1311 C C   . LYS A 1 227 ? 127.622 99.036  97.437  1.00 103.94 ? 227 LYS A C   1 
ATOM   1312 O O   . LYS A 1 227 ? 126.788 99.898  97.220  1.00 104.67 ? 227 LYS A O   1 
ATOM   1313 C CB  . LYS A 1 227 ? 127.678 96.683  96.666  1.00 122.19 ? 227 LYS A CB  1 
ATOM   1314 C CG  . LYS A 1 227 ? 127.300 95.215  96.780  1.00 133.37 ? 227 LYS A CG  1 
ATOM   1315 C CD  . LYS A 1 227 ? 127.581 94.480  95.485  1.00 150.71 ? 227 LYS A CD  1 
ATOM   1316 C CE  . LYS A 1 227 ? 127.168 93.027  95.509  1.00 170.09 ? 227 LYS A CE  1 
ATOM   1317 N NZ  . LYS A 1 227 ? 127.550 92.365  94.232  1.00 163.81 ? 227 LYS A NZ  1 
ATOM   1318 N N   . GLU A 1 228 ? 128.928 99.289  97.290  1.00 120.98 ? 228 GLU A N   1 
ATOM   1319 C CA  . GLU A 1 228 ? 129.423 100.626 96.974  1.00 137.27 ? 228 GLU A CA  1 
ATOM   1320 C C   . GLU A 1 228 ? 129.171 100.989 95.507  1.00 129.43 ? 228 GLU A C   1 
ATOM   1321 O O   . GLU A 1 228 ? 128.951 102.159 95.194  1.00 115.76 ? 228 GLU A O   1 
ATOM   1322 C CB  . GLU A 1 228 ? 130.909 100.725 97.340  1.00 183.71 ? 228 GLU A CB  1 
ATOM   1323 C CG  . GLU A 1 228 ? 131.509 102.119 97.185  1.00 213.78 ? 228 GLU A CG  1 
ATOM   1324 C CD  . GLU A 1 228 ? 132.188 102.415 95.852  1.00 234.76 ? 228 GLU A CD  1 
ATOM   1325 O OE1 . GLU A 1 228 ? 132.804 101.483 95.278  1.00 225.63 ? 228 GLU A OE1 1 
ATOM   1326 O OE2 . GLU A 1 228 ? 132.154 103.595 95.417  1.00 227.70 ? 228 GLU A OE2 1 
ATOM   1327 N N   . SER A 1 229 ? 129.191 99.988  94.608  1.00 130.46 ? 229 SER A N   1 
ATOM   1328 C CA  . SER A 1 229 ? 129.123 100.205 93.166  1.00 133.78 ? 229 SER A CA  1 
ATOM   1329 C C   . SER A 1 229 ? 127.686 100.272 92.636  1.00 109.11 ? 229 SER A C   1 
ATOM   1330 O O   . SER A 1 229 ? 127.422 100.998 91.679  1.00 106.66 ? 229 SER A O   1 
ATOM   1331 C CB  . SER A 1 229 ? 129.927 99.156  92.442  1.00 131.56 ? 229 SER A CB  1 
ATOM   1332 O OG  . SER A 1 229 ? 129.470 97.852  92.746  1.00 105.49 ? 229 SER A OG  1 
ATOM   1333 N N   . THR A 1 230 ? 126.765 99.506  93.242  1.00 86.47  ? 230 THR A N   1 
ATOM   1334 C CA  . THR A 1 230 ? 125.403 99.364  92.747  1.00 76.73  ? 230 THR A CA  1 
ATOM   1335 C C   . THR A 1 230 ? 124.391 100.293 93.420  1.00 70.60  ? 230 THR A C   1 
ATOM   1336 O O   . THR A 1 230 ? 123.222 100.218 93.079  1.00 66.89  ? 230 THR A O   1 
ATOM   1337 C CB  . THR A 1 230 ? 124.889 97.931  92.931  1.00 93.52  ? 230 THR A CB  1 
ATOM   1338 O OG1 . THR A 1 230 ? 125.035 97.550  94.297  1.00 90.72  ? 230 THR A OG1 1 
ATOM   1339 C CG2 . THR A 1 230 ? 125.627 96.918  92.084  1.00 128.53 ? 230 THR A CG2 1 
ATOM   1340 N N   . TRP A 1 231 ? 124.793 101.198 94.322  1.00 73.50  ? 231 TRP A N   1 
ATOM   1341 C CA  . TRP A 1 231 ? 123.808 101.941 95.115  1.00 63.06  ? 231 TRP A CA  1 
ATOM   1342 C C   . TRP A 1 231 ? 122.785 102.697 94.258  1.00 67.74  ? 231 TRP A C   1 
ATOM   1343 O O   . TRP A 1 231 ? 121.629 102.748 94.669  1.00 69.37  ? 231 TRP A O   1 
ATOM   1344 C CB  . TRP A 1 231 ? 124.441 102.847 96.193  1.00 64.93  ? 231 TRP A CB  1 
ATOM   1345 C CG  . TRP A 1 231 ? 125.077 104.154 95.773  1.00 75.88  ? 231 TRP A CG  1 
ATOM   1346 C CD1 . TRP A 1 231 ? 126.423 104.392 95.726  1.00 91.19  ? 231 TRP A CD1 1 
ATOM   1347 C CD2 . TRP A 1 231 ? 124.450 105.414 95.404  1.00 73.50  ? 231 TRP A CD2 1 
ATOM   1348 N NE1 . TRP A 1 231 ? 126.681 105.678 95.329  1.00 80.47  ? 231 TRP A NE1 1 
ATOM   1349 C CE2 . TRP A 1 231 ? 125.491 106.331 95.123  1.00 80.58  ? 231 TRP A CE2 1 
ATOM   1350 C CE3 . TRP A 1 231 ? 123.129 105.859 95.252  1.00 68.12  ? 231 TRP A CE3 1 
ATOM   1351 C CZ2 . TRP A 1 231 ? 125.238 107.647 94.727  1.00 86.55  ? 231 TRP A CZ2 1 
ATOM   1352 C CZ3 . TRP A 1 231 ? 122.887 107.148 94.832  1.00 72.31  ? 231 TRP A CZ3 1 
ATOM   1353 C CH2 . TRP A 1 231 ? 123.926 108.037 94.608  1.00 90.79  ? 231 TRP A CH2 1 
ATOM   1354 N N   . PRO A 1 232 ? 123.080 103.294 93.065  1.00 75.01  ? 232 PRO A N   1 
ATOM   1355 C CA  . PRO A 1 232 ? 122.046 103.972 92.286  1.00 78.02  ? 232 PRO A CA  1 
ATOM   1356 C C   . PRO A 1 232 ? 120.847 103.099 91.922  1.00 81.87  ? 232 PRO A C   1 
ATOM   1357 O O   . PRO A 1 232 ? 119.748 103.613 91.769  1.00 90.88  ? 232 PRO A O   1 
ATOM   1358 C CB  . PRO A 1 232 ? 122.776 104.455 91.024  1.00 72.94  ? 232 PRO A CB  1 
ATOM   1359 C CG  . PRO A 1 232 ? 124.212 104.581 91.449  1.00 65.65  ? 232 PRO A CG  1 
ATOM   1360 C CD  . PRO A 1 232 ? 124.392 103.422 92.411  1.00 66.72  ? 232 PRO A CD  1 
ATOM   1361 N N   . TYR A 1 233 ? 121.019 101.775 91.828  1.00 64.72  ? 233 TYR A N   1 
ATOM   1362 C CA  . TYR A 1 233 ? 119.904 100.905 91.491  1.00 59.58  ? 233 TYR A CA  1 
ATOM   1363 C C   . TYR A 1 233 ? 118.934 100.736 92.669  1.00 64.38  ? 233 TYR A C   1 
ATOM   1364 O O   . TYR A 1 233 ? 117.804 100.335 92.440  1.00 72.71  ? 233 TYR A O   1 
ATOM   1365 C CB  . TYR A 1 233 ? 120.392 99.561  90.945  1.00 80.40  ? 233 TYR A CB  1 
ATOM   1366 C CG  . TYR A 1 233 ? 121.474 99.681  89.878  1.00 109.87 ? 233 TYR A CG  1 
ATOM   1367 C CD1 . TYR A 1 233 ? 121.448 100.687 88.913  1.00 121.62 ? 233 TYR A CD1 1 
ATOM   1368 C CD2 . TYR A 1 233 ? 122.533 98.785  89.842  1.00 130.32 ? 233 TYR A CD2 1 
ATOM   1369 C CE1 . TYR A 1 233 ? 122.448 100.808 87.963  1.00 129.37 ? 233 TYR A CE1 1 
ATOM   1370 C CE2 . TYR A 1 233 ? 123.518 98.869  88.867  1.00 139.70 ? 233 TYR A CE2 1 
ATOM   1371 C CZ  . TYR A 1 233 ? 123.484 99.891  87.934  1.00 148.64 ? 233 TYR A CZ  1 
ATOM   1372 O OH  . TYR A 1 233 ? 124.483 99.971  86.999  1.00 185.94 ? 233 TYR A OH  1 
ATOM   1373 N N   . LEU A 1 234 ? 119.302 101.075 93.918  1.00 72.30  ? 234 LEU A N   1 
ATOM   1374 C CA  . LEU A 1 234 ? 118.334 101.131 95.008  1.00 68.38  ? 234 LEU A CA  1 
ATOM   1375 C C   . LEU A 1 234 ? 117.215 102.123 94.682  1.00 72.64  ? 234 LEU A C   1 
ATOM   1376 O O   . LEU A 1 234 ? 116.068 101.896 95.057  1.00 80.15  ? 234 LEU A O   1 
ATOM   1377 C CB  . LEU A 1 234 ? 119.003 101.576 96.310  1.00 64.98  ? 234 LEU A CB  1 
ATOM   1378 C CG  . LEU A 1 234 ? 119.971 100.606 96.956  1.00 76.28  ? 234 LEU A CG  1 
ATOM   1379 C CD1 . LEU A 1 234 ? 120.744 101.332 98.056  1.00 83.61  ? 234 LEU A CD1 1 
ATOM   1380 C CD2 . LEU A 1 234 ? 119.251 99.393  97.515  1.00 81.94  ? 234 LEU A CD2 1 
ATOM   1381 N N   . PHE A 1 235 ? 117.563 103.224 94.006  1.00 65.05  ? 235 PHE A N   1 
ATOM   1382 C CA  . PHE A 1 235 ? 116.612 104.238 93.580  1.00 74.71  ? 235 PHE A CA  1 
ATOM   1383 C C   . PHE A 1 235 ? 116.044 103.902 92.198  1.00 65.84  ? 235 PHE A C   1 
ATOM   1384 O O   . PHE A 1 235 ? 114.852 104.080 91.976  1.00 81.17  ? 235 PHE A O   1 
ATOM   1385 C CB  . PHE A 1 235 ? 117.276 105.617 93.595  1.00 81.01  ? 235 PHE A CB  1 
ATOM   1386 C CG  . PHE A 1 235 ? 117.815 106.014 94.946  1.00 78.44  ? 235 PHE A CG  1 
ATOM   1387 C CD1 . PHE A 1 235 ? 116.964 106.269 96.002  1.00 72.50  ? 235 PHE A CD1 1 
ATOM   1388 C CD2 . PHE A 1 235 ? 119.179 106.102 95.159  1.00 84.19  ? 235 PHE A CD2 1 
ATOM   1389 C CE1 . PHE A 1 235 ? 117.481 106.599 97.245  1.00 87.65  ? 235 PHE A CE1 1 
ATOM   1390 C CE2 . PHE A 1 235 ? 119.668 106.481 96.402  1.00 86.06  ? 235 PHE A CE2 1 
ATOM   1391 C CZ  . PHE A 1 235 ? 118.827 106.672 97.456  1.00 77.55  ? 235 PHE A CZ  1 
ATOM   1392 N N   . GLY A 1 236 ? 116.874 103.406 91.283  1.00 67.98  ? 236 GLY A N   1 
ATOM   1393 C CA  . GLY A 1 236 ? 116.428 103.062 89.939  1.00 86.57  ? 236 GLY A CA  1 
ATOM   1394 C C   . GLY A 1 236 ? 115.434 101.884 89.859  1.00 96.58  ? 236 GLY A C   1 
ATOM   1395 O O   . GLY A 1 236 ? 114.787 101.707 88.830  1.00 90.73  ? 236 GLY A O   1 
ATOM   1396 N N   . VAL A 1 237 ? 115.323 101.065 90.924  1.00 91.33  ? 237 VAL A N   1 
ATOM   1397 C CA  . VAL A 1 237 ? 114.389 99.952  90.963  1.00 80.07  ? 237 VAL A CA  1 
ATOM   1398 C C   . VAL A 1 237 ? 112.957 100.432 91.206  1.00 80.71  ? 237 VAL A C   1 
ATOM   1399 O O   . VAL A 1 237 ? 112.016 99.673  90.969  1.00 109.48 ? 237 VAL A O   1 
ATOM   1400 C CB  . VAL A 1 237 ? 114.860 98.883  91.975  1.00 87.44  ? 237 VAL A CB  1 
ATOM   1401 C CG1 . VAL A 1 237 ? 113.753 98.014  92.578  1.00 125.13 ? 237 VAL A CG1 1 
ATOM   1402 C CG2 . VAL A 1 237 ? 115.895 97.992  91.309  1.00 91.65  ? 237 VAL A CG2 1 
ATOM   1403 N N   . ILE A 1 238 ? 112.753 101.688 91.622  1.00 88.37  ? 238 ILE A N   1 
ATOM   1404 C CA  . ILE A 1 238 ? 111.402 102.215 91.836  1.00 86.04  ? 238 ILE A CA  1 
ATOM   1405 C C   . ILE A 1 238 ? 110.586 102.196 90.529  1.00 92.65  ? 238 ILE A C   1 
ATOM   1406 O O   . ILE A 1 238 ? 109.360 102.211 90.564  1.00 90.80  ? 238 ILE A O   1 
ATOM   1407 C CB  . ILE A 1 238 ? 111.494 103.617 92.478  1.00 73.95  ? 238 ILE A CB  1 
ATOM   1408 C CG1 . ILE A 1 238 ? 111.957 103.495 93.925  1.00 93.74  ? 238 ILE A CG1 1 
ATOM   1409 C CG2 . ILE A 1 238 ? 110.193 104.360 92.405  1.00 80.26  ? 238 ILE A CG2 1 
ATOM   1410 C CD1 . ILE A 1 238 ? 112.413 104.787 94.561  1.00 93.14  ? 238 ILE A CD1 1 
ATOM   1411 N N   . VAL A 1 239 ? 111.253 102.128 89.361  1.00 84.45  ? 239 VAL A N   1 
ATOM   1412 C CA  . VAL A 1 239 ? 110.579 102.064 88.079  1.00 74.17  ? 239 VAL A CA  1 
ATOM   1413 C C   . VAL A 1 239 ? 109.760 100.772 87.957  1.00 96.41  ? 239 VAL A C   1 
ATOM   1414 O O   . VAL A 1 239 ? 108.730 100.776 87.285  1.00 110.21 ? 239 VAL A O   1 
ATOM   1415 C CB  . VAL A 1 239 ? 111.588 102.222 86.931  1.00 88.00  ? 239 VAL A CB  1 
ATOM   1416 C CG1 . VAL A 1 239 ? 111.030 101.840 85.559  1.00 114.11 ? 239 VAL A CG1 1 
ATOM   1417 C CG2 . VAL A 1 239 ? 112.147 103.641 86.917  1.00 105.05 ? 239 VAL A CG2 1 
ATOM   1418 N N   . VAL A 1 240 ? 110.157 99.670  88.617  1.00 97.75  ? 240 VAL A N   1 
ATOM   1419 C CA  . VAL A 1 240 ? 109.449 98.404  88.457  1.00 84.76  ? 240 VAL A CA  1 
ATOM   1420 C C   . VAL A 1 240 ? 108.067 98.461  89.114  1.00 82.72  ? 240 VAL A C   1 
ATOM   1421 O O   . VAL A 1 240 ? 107.084 98.207  88.420  1.00 96.50  ? 240 VAL A O   1 
ATOM   1422 C CB  . VAL A 1 240 ? 110.295 97.191  88.897  1.00 76.82  ? 240 VAL A CB  1 
ATOM   1423 C CG1 . VAL A 1 240 ? 109.471 95.923  89.091  1.00 82.54  ? 240 VAL A CG1 1 
ATOM   1424 C CG2 . VAL A 1 240 ? 111.414 96.936  87.895  1.00 92.99  ? 240 VAL A CG2 1 
ATOM   1425 N N   . PRO A 1 241 ? 107.892 98.784  90.427  1.00 102.52 ? 241 PRO A N   1 
ATOM   1426 C CA  . PRO A 1 241 ? 106.557 98.976  90.992  1.00 98.70  ? 241 PRO A CA  1 
ATOM   1427 C C   . PRO A 1 241 ? 105.673 99.965  90.240  1.00 76.88  ? 241 PRO A C   1 
ATOM   1428 O O   . PRO A 1 241 ? 104.468 99.756  90.162  1.00 96.73  ? 241 PRO A O   1 
ATOM   1429 C CB  . PRO A 1 241 ? 106.816 99.447  92.423  1.00 103.24 ? 241 PRO A CB  1 
ATOM   1430 C CG  . PRO A 1 241 ? 108.138 98.814  92.772  1.00 126.71 ? 241 PRO A CG  1 
ATOM   1431 C CD  . PRO A 1 241 ? 108.928 98.874  91.472  1.00 131.41 ? 241 PRO A CD  1 
ATOM   1432 N N   . ALA A 1 242 ? 106.257 101.008 89.655  1.00 73.18  ? 242 ALA A N   1 
ATOM   1433 C CA  . ALA A 1 242 ? 105.485 101.980 88.900  1.00 87.76  ? 242 ALA A CA  1 
ATOM   1434 C C   . ALA A 1 242 ? 104.971 101.389 87.582  1.00 91.04  ? 242 ALA A C   1 
ATOM   1435 O O   . ALA A 1 242 ? 103.810 101.590 87.247  1.00 102.28 ? 242 ALA A O   1 
ATOM   1436 C CB  . ALA A 1 242 ? 106.315 103.231 88.683  1.00 114.56 ? 242 ALA A CB  1 
ATOM   1437 N N   . VAL A 1 243 ? 105.807 100.663 86.822  1.00 96.68  ? 243 VAL A N   1 
ATOM   1438 C CA  . VAL A 1 243 ? 105.406 100.112 85.531  1.00 104.66 ? 243 VAL A CA  1 
ATOM   1439 C C   . VAL A 1 243 ? 104.494 98.886  85.704  1.00 95.74  ? 243 VAL A C   1 
ATOM   1440 O O   . VAL A 1 243 ? 103.597 98.670  84.887  1.00 112.28 ? 243 VAL A O   1 
ATOM   1441 C CB  . VAL A 1 243 ? 106.636 99.817  84.647  1.00 127.07 ? 243 VAL A CB  1 
ATOM   1442 C CG1 . VAL A 1 243 ? 106.317 98.958  83.422  1.00 133.78 ? 243 VAL A CG1 1 
ATOM   1443 C CG2 . VAL A 1 243 ? 107.310 101.114 84.225  1.00 126.81 ? 243 VAL A CG2 1 
ATOM   1444 N N   . VAL A 1 244 ? 104.665 98.111  86.785  1.00 100.02 ? 244 VAL A N   1 
ATOM   1445 C CA  . VAL A 1 244 ? 103.740 97.029  87.116  1.00 109.92 ? 244 VAL A CA  1 
ATOM   1446 C C   . VAL A 1 244 ? 102.346 97.575  87.465  1.00 106.14 ? 244 VAL A C   1 
ATOM   1447 O O   . VAL A 1 244 ? 101.363 96.862  87.308  1.00 111.24 ? 244 VAL A O   1 
ATOM   1448 C CB  . VAL A 1 244 ? 104.315 96.138  88.244  1.00 146.43 ? 244 VAL A CB  1 
ATOM   1449 C CG1 . VAL A 1 244 ? 103.261 95.260  88.918  1.00 142.94 ? 244 VAL A CG1 1 
ATOM   1450 C CG2 . VAL A 1 244 ? 105.479 95.299  87.732  1.00 165.01 ? 244 VAL A CG2 1 
ATOM   1451 N N   . GLN A 1 245 ? 102.230 98.834  87.918  1.00 100.37 ? 245 GLN A N   1 
ATOM   1452 C CA  . GLN A 1 245 ? 100.933 99.467  88.109  1.00 84.60  ? 245 GLN A CA  1 
ATOM   1453 C C   . GLN A 1 245 ? 100.353 99.952  86.776  1.00 92.83  ? 245 GLN A C   1 
ATOM   1454 O O   . GLN A 1 245 ? 99.192  99.685  86.502  1.00 108.37 ? 245 GLN A O   1 
ATOM   1455 C CB  . GLN A 1 245 ? 101.026 100.606 89.119  1.00 91.71  ? 245 GLN A CB  1 
ATOM   1456 C CG  . GLN A 1 245 ? 99.707  101.323 89.346  1.00 100.90 ? 245 GLN A CG  1 
ATOM   1457 C CD  . GLN A 1 245 ? 99.783  102.272 90.523  1.00 113.73 ? 245 GLN A CD  1 
ATOM   1458 O OE1 . GLN A 1 245 ? 100.411 103.321 90.459  1.00 86.51  ? 245 GLN A OE1 1 
ATOM   1459 N NE2 . GLN A 1 245 ? 99.137  101.923 91.619  1.00 117.66 ? 245 GLN A NE2 1 
ATOM   1460 N N   . LEU A 1 246 ? 101.140 100.638 85.931  1.00 108.99 ? 246 LEU A N   1 
ATOM   1461 C CA  . LEU A 1 246 ? 100.662 101.160 84.647  1.00 92.20  ? 246 LEU A CA  1 
ATOM   1462 C C   . LEU A 1 246 ? 100.218 100.044 83.692  1.00 104.81 ? 246 LEU A C   1 
ATOM   1463 O O   . LEU A 1 246 ? 99.350  100.275 82.861  1.00 105.02 ? 246 LEU A O   1 
ATOM   1464 C CB  . LEU A 1 246 ? 101.758 101.991 83.978  1.00 85.59  ? 246 LEU A CB  1 
ATOM   1465 C CG  . LEU A 1 246 ? 102.039 103.350 84.606  1.00 115.19 ? 246 LEU A CG  1 
ATOM   1466 C CD1 . LEU A 1 246 ? 103.211 104.044 83.924  1.00 140.98 ? 246 LEU A CD1 1 
ATOM   1467 C CD2 . LEU A 1 246 ? 100.804 104.227 84.547  1.00 143.25 ? 246 LEU A CD2 1 
ATOM   1468 N N   . LEU A 1 247 ? 100.815 98.846  83.793  1.00 128.54 ? 247 LEU A N   1 
ATOM   1469 C CA  . LEU A 1 247 ? 100.403 97.702  82.986  1.00 137.62 ? 247 LEU A CA  1 
ATOM   1470 C C   . LEU A 1 247 ? 99.347  96.850  83.710  1.00 141.23 ? 247 LEU A C   1 
ATOM   1471 O O   . LEU A 1 247 ? 99.181  95.675  83.369  1.00 172.01 ? 247 LEU A O   1 
ATOM   1472 C CB  . LEU A 1 247 ? 101.644 96.855  82.645  1.00 136.59 ? 247 LEU A CB  1 
ATOM   1473 C CG  . LEU A 1 247 ? 102.669 97.518  81.725  1.00 137.16 ? 247 LEU A CG  1 
ATOM   1474 C CD1 . LEU A 1 247 ? 103.892 96.646  81.526  1.00 151.04 ? 247 LEU A CD1 1 
ATOM   1475 C CD2 . LEU A 1 247 ? 102.045 97.836  80.381  1.00 156.54 ? 247 LEU A CD2 1 
ATOM   1476 N N   . SER A 1 248 ? 98.621  97.428  84.684  1.00 108.49 ? 248 SER A N   1 
ATOM   1477 C CA  . SER A 1 248 ? 97.622  96.692  85.453  1.00 115.42 ? 248 SER A CA  1 
ATOM   1478 C C   . SER A 1 248 ? 96.315  97.459  85.642  1.00 115.99 ? 248 SER A C   1 
ATOM   1479 O O   . SER A 1 248 ? 95.255  96.906  85.341  1.00 146.66 ? 248 SER A O   1 
ATOM   1480 C CB  . SER A 1 248 ? 98.179  96.259  86.789  1.00 139.24 ? 248 SER A CB  1 
ATOM   1481 O OG  . SER A 1 248 ? 97.220  95.505  87.522  1.00 137.93 ? 248 SER A OG  1 
ATOM   1482 N N   . LEU A 1 249 ? 96.359  98.723  86.100  1.00 125.36 ? 249 LEU A N   1 
ATOM   1483 C CA  . LEU A 1 249 ? 95.135  99.443  86.461  1.00 114.17 ? 249 LEU A CA  1 
ATOM   1484 C C   . LEU A 1 249 ? 94.297  99.842  85.241  1.00 121.87 ? 249 LEU A C   1 
ATOM   1485 O O   . LEU A 1 249 ? 93.078  99.825  85.357  1.00 160.91 ? 249 LEU A O   1 
ATOM   1486 C CB  . LEU A 1 249 ? 95.434  100.686 87.305  1.00 96.41  ? 249 LEU A CB  1 
ATOM   1487 C CG  . LEU A 1 249 ? 95.803  100.464 88.772  1.00 97.49  ? 249 LEU A CG  1 
ATOM   1488 C CD1 . LEU A 1 249 ? 95.900  101.788 89.509  1.00 104.72 ? 249 LEU A CD1 1 
ATOM   1489 C CD2 . LEU A 1 249 ? 94.821  99.556  89.476  1.00 112.45 ? 249 LEU A CD2 1 
ATOM   1490 N N   . PRO A 1 250 ? 94.846  100.262 84.068  1.00 104.50 ? 250 PRO A N   1 
ATOM   1491 C CA  . PRO A 1 250 ? 94.022  100.772 82.967  1.00 125.27 ? 250 PRO A CA  1 
ATOM   1492 C C   . PRO A 1 250 ? 92.842  99.916  82.498  1.00 152.89 ? 250 PRO A C   1 
ATOM   1493 O O   . PRO A 1 250 ? 91.826  100.466 82.084  1.00 185.24 ? 250 PRO A O   1 
ATOM   1494 C CB  . PRO A 1 250 ? 95.017  100.935 81.819  1.00 123.83 ? 250 PRO A CB  1 
ATOM   1495 C CG  . PRO A 1 250 ? 96.309  101.239 82.538  1.00 135.82 ? 250 PRO A CG  1 
ATOM   1496 C CD  . PRO A 1 250 ? 96.271  100.339 83.744  1.00 98.60  ? 250 PRO A CD  1 
ATOM   1497 N N   . PHE A 1 251 ? 92.964  98.584  82.593  1.00 138.53 ? 251 PHE A N   1 
ATOM   1498 C CA  . PHE A 1 251 ? 91.943  97.654  82.132  1.00 161.19 ? 251 PHE A CA  1 
ATOM   1499 C C   . PHE A 1 251 ? 90.768  97.535  83.115  1.00 147.49 ? 251 PHE A C   1 
ATOM   1500 O O   . PHE A 1 251 ? 89.721  96.993  82.757  1.00 157.02 ? 251 PHE A O   1 
ATOM   1501 C CB  . PHE A 1 251 ? 92.559  96.271  81.896  1.00 186.92 ? 251 PHE A CB  1 
ATOM   1502 C CG  . PHE A 1 251 ? 93.860  96.282  81.131  1.00 190.37 ? 251 PHE A CG  1 
ATOM   1503 C CD1 . PHE A 1 251 ? 93.955  96.948  79.919  1.00 200.95 ? 251 PHE A CD1 1 
ATOM   1504 C CD2 . PHE A 1 251 ? 94.987  95.643  81.631  1.00 213.76 ? 251 PHE A CD2 1 
ATOM   1505 C CE1 . PHE A 1 251 ? 95.150  96.974  79.217  1.00 237.05 ? 251 PHE A CE1 1 
ATOM   1506 C CE2 . PHE A 1 251 ? 96.182  95.671  80.929  1.00 255.91 ? 251 PHE A CE2 1 
ATOM   1507 C CZ  . PHE A 1 251 ? 96.258  96.333  79.722  1.00 265.20 ? 251 PHE A CZ  1 
ATOM   1508 N N   . LEU A 1 252 ? 90.937  98.023  84.353  1.00 104.65 ? 252 LEU A N   1 
ATOM   1509 C CA  . LEU A 1 252 ? 89.905  97.941  85.381  1.00 117.26 ? 252 LEU A CA  1 
ATOM   1510 C C   . LEU A 1 252 ? 88.949  99.133  85.271  1.00 132.41 ? 252 LEU A C   1 
ATOM   1511 O O   . LEU A 1 252 ? 89.346  100.214 84.836  1.00 166.68 ? 252 LEU A O   1 
ATOM   1512 C CB  . LEU A 1 252 ? 90.580  97.917  86.761  1.00 122.21 ? 252 LEU A CB  1 
ATOM   1513 C CG  . LEU A 1 252 ? 91.717  96.909  86.927  1.00 121.74 ? 252 LEU A CG  1 
ATOM   1514 C CD1 . LEU A 1 252 ? 92.259  96.923  88.342  1.00 119.04 ? 252 LEU A CD1 1 
ATOM   1515 C CD2 . LEU A 1 252 ? 91.236  95.518  86.549  1.00 130.79 ? 252 LEU A CD2 1 
ATOM   1516 N N   . PRO A 1 253 ? 87.659  98.999  85.665  1.00 131.84 ? 253 PRO A N   1 
ATOM   1517 C CA  . PRO A 1 253 ? 86.737  100.135 85.680  1.00 138.98 ? 253 PRO A CA  1 
ATOM   1518 C C   . PRO A 1 253 ? 87.182  101.271 86.603  1.00 139.76 ? 253 PRO A C   1 
ATOM   1519 O O   . PRO A 1 253 ? 87.837  101.030 87.619  1.00 126.55 ? 253 PRO A O   1 
ATOM   1520 C CB  . PRO A 1 253 ? 85.412  99.529  86.179  1.00 152.66 ? 253 PRO A CB  1 
ATOM   1521 C CG  . PRO A 1 253 ? 85.526  98.059  85.839  1.00 159.28 ? 253 PRO A CG  1 
ATOM   1522 C CD  . PRO A 1 253 ? 86.995  97.741  86.032  1.00 152.19 ? 253 PRO A CD  1 
ATOM   1523 N N   . ASP A 1 254 ? 86.815  102.509 86.237  1.00 134.20 ? 254 ASP A N   1 
ATOM   1524 C CA  . ASP A 1 254 ? 86.986  103.663 87.117  1.00 142.90 ? 254 ASP A CA  1 
ATOM   1525 C C   . ASP A 1 254 ? 86.008  103.515 88.289  1.00 142.69 ? 254 ASP A C   1 
ATOM   1526 O O   . ASP A 1 254 ? 85.072  102.720 88.226  1.00 177.19 ? 254 ASP A O   1 
ATOM   1527 C CB  . ASP A 1 254 ? 86.762  104.966 86.340  1.00 156.26 ? 254 ASP A CB  1 
ATOM   1528 C CG  . ASP A 1 254 ? 87.379  106.208 86.975  1.00 171.63 ? 254 ASP A CG  1 
ATOM   1529 O OD1 . ASP A 1 254 ? 87.925  106.102 88.093  1.00 171.09 ? 254 ASP A OD1 1 
ATOM   1530 O OD2 . ASP A 1 254 ? 87.326  107.273 86.328  1.00 185.58 ? 254 ASP A OD2 1 
ATOM   1531 N N   . SER A 1 255 ? 86.206  104.264 89.381  1.00 136.93 ? 255 SER A N   1 
ATOM   1532 C CA  . SER A 1 255 ? 85.377  104.074 90.566  1.00 135.14 ? 255 SER A CA  1 
ATOM   1533 C C   . SER A 1 255 ? 83.911  104.312 90.201  1.00 137.90 ? 255 SER A C   1 
ATOM   1534 O O   . SER A 1 255 ? 83.605  105.258 89.484  1.00 155.72 ? 255 SER A O   1 
ATOM   1535 C CB  . SER A 1 255 ? 85.801  104.986 91.695  1.00 158.80 ? 255 SER A CB  1 
ATOM   1536 O OG  . SER A 1 255 ? 84.949  106.121 91.787  1.00 153.50 ? 255 SER A OG  1 
ATOM   1537 N N   . PRO A 1 256 ? 82.960  103.474 90.676  1.00 113.57 ? 256 PRO A N   1 
ATOM   1538 C CA  . PRO A 1 256 ? 81.534  103.688 90.408  1.00 100.30 ? 256 PRO A CA  1 
ATOM   1539 C C   . PRO A 1 256 ? 81.027  105.089 90.739  1.00 109.37 ? 256 PRO A C   1 
ATOM   1540 O O   . PRO A 1 256 ? 80.498  105.760 89.863  1.00 114.61 ? 256 PRO A O   1 
ATOM   1541 C CB  . PRO A 1 256 ? 80.848  102.654 91.301  1.00 113.41 ? 256 PRO A CB  1 
ATOM   1542 C CG  . PRO A 1 256 ? 81.923  102.202 92.271  1.00 133.42 ? 256 PRO A CG  1 
ATOM   1543 C CD  . PRO A 1 256 ? 83.206  102.275 91.483  1.00 116.08 ? 256 PRO A CD  1 
ATOM   1544 N N   . ARG A 1 257 ? 81.216  105.535 91.991  1.00 127.51 ? 257 ARG A N   1 
ATOM   1545 C CA  . ARG A 1 257 ? 80.731  106.837 92.440  1.00 113.84 ? 257 ARG A CA  1 
ATOM   1546 C C   . ARG A 1 257 ? 81.126  107.930 91.454  1.00 109.46 ? 257 ARG A C   1 
ATOM   1547 O O   . ARG A 1 257 ? 80.268  108.666 90.982  1.00 130.11 ? 257 ARG A O   1 
ATOM   1548 C CB  . ARG A 1 257 ? 81.245  107.206 93.834  1.00 109.90 ? 257 ARG A CB  1 
ATOM   1549 C CG  . ARG A 1 257 ? 81.080  108.680 94.175  1.00 135.29 ? 257 ARG A CG  1 
ATOM   1550 C CD  . ARG A 1 257 ? 81.283  108.977 95.648  1.00 176.03 ? 257 ARG A CD  1 
ATOM   1551 N NE  . ARG A 1 257 ? 81.044  110.387 95.942  1.00 195.41 ? 257 ARG A NE  1 
ATOM   1552 C CZ  . ARG A 1 257 ? 80.768  110.878 97.149  1.00 222.01 ? 257 ARG A CZ  1 
ATOM   1553 N NH1 . ARG A 1 257 ? 80.684  112.184 97.330  1.00 229.37 ? 257 ARG A NH1 1 
ATOM   1554 N NH2 . ARG A 1 257 ? 80.606  110.070 98.182  1.00 231.90 ? 257 ARG A NH2 1 
ATOM   1555 N N   . TYR A 1 258 ? 82.424  108.060 91.165  1.00 129.07 ? 258 TYR A N   1 
ATOM   1556 C CA  . TYR A 1 258 ? 82.886  109.118 90.276  1.00 139.92 ? 258 TYR A CA  1 
ATOM   1557 C C   . TYR A 1 258 ? 82.144  109.051 88.938  1.00 136.61 ? 258 TYR A C   1 
ATOM   1558 O O   . TYR A 1 258 ? 81.797  110.080 88.370  1.00 133.17 ? 258 TYR A O   1 
ATOM   1559 C CB  . TYR A 1 258 ? 84.399  109.029 90.096  1.00 138.28 ? 258 TYR A CB  1 
ATOM   1560 C CG  . TYR A 1 258 ? 84.951  110.034 89.101  1.00 166.24 ? 258 TYR A CG  1 
ATOM   1561 C CD1 . TYR A 1 258 ? 84.997  111.393 89.398  1.00 169.09 ? 258 TYR A CD1 1 
ATOM   1562 C CD2 . TYR A 1 258 ? 85.395  109.627 87.847  1.00 183.76 ? 258 TYR A CD2 1 
ATOM   1563 C CE1 . TYR A 1 258 ? 85.498  112.313 88.490  1.00 156.78 ? 258 TYR A CE1 1 
ATOM   1564 C CE2 . TYR A 1 258 ? 85.902  110.539 86.931  1.00 162.26 ? 258 TYR A CE2 1 
ATOM   1565 C CZ  . TYR A 1 258 ? 85.950  111.883 87.252  1.00 150.40 ? 258 TYR A CZ  1 
ATOM   1566 O OH  . TYR A 1 258 ? 86.485  112.760 86.354  1.00 161.75 ? 258 TYR A OH  1 
ATOM   1567 N N   . LEU A 1 259 ? 81.827  107.840 88.467  1.00 134.37 ? 259 LEU A N   1 
ATOM   1568 C CA  . LEU A 1 259 ? 81.133  107.684 87.194  1.00 153.01 ? 259 LEU A CA  1 
ATOM   1569 C C   . LEU A 1 259 ? 79.624  107.920 87.324  1.00 156.33 ? 259 LEU A C   1 
ATOM   1570 O O   . LEU A 1 259 ? 78.911  107.773 86.332  1.00 166.68 ? 259 LEU A O   1 
ATOM   1571 C CB  . LEU A 1 259 ? 81.419  106.286 86.629  1.00 148.23 ? 259 LEU A CB  1 
ATOM   1572 C CG  . LEU A 1 259 ? 82.640  106.172 85.717  1.00 162.77 ? 259 LEU A CG  1 
ATOM   1573 C CD1 . LEU A 1 259 ? 82.857  104.733 85.288  1.00 155.08 ? 259 LEU A CD1 1 
ATOM   1574 C CD2 . LEU A 1 259 ? 82.498  107.073 84.496  1.00 188.17 ? 259 LEU A CD2 1 
ATOM   1575 N N   . LEU A 1 260 ? 79.132  108.274 88.524  1.00 152.77 ? 260 LEU A N   1 
ATOM   1576 C CA  . LEU A 1 260 ? 77.701  108.454 88.749  1.00 158.76 ? 260 LEU A CA  1 
ATOM   1577 C C   . LEU A 1 260 ? 77.386  109.820 89.365  1.00 160.19 ? 260 LEU A C   1 
ATOM   1578 O O   . LEU A 1 260 ? 76.266  110.305 89.212  1.00 175.94 ? 260 LEU A O   1 
ATOM   1579 C CB  . LEU A 1 260 ? 77.193  107.316 89.646  1.00 157.95 ? 260 LEU A CB  1 
ATOM   1580 C CG  . LEU A 1 260 ? 75.680  107.222 89.837  1.00 174.15 ? 260 LEU A CG  1 
ATOM   1581 C CD1 . LEU A 1 260 ? 74.971  106.924 88.522  1.00 178.45 ? 260 LEU A CD1 1 
ATOM   1582 C CD2 . LEU A 1 260 ? 75.344  106.164 90.876  1.00 178.80 ? 260 LEU A CD2 1 
ATOM   1583 N N   . LEU A 1 261 ? 78.356  110.439 90.059  1.00 165.53 ? 261 LEU A N   1 
ATOM   1584 C CA  . LEU A 1 261 ? 78.116  111.699 90.751  1.00 181.31 ? 261 LEU A CA  1 
ATOM   1585 C C   . LEU A 1 261 ? 78.873  112.871 90.115  1.00 197.87 ? 261 LEU A C   1 
ATOM   1586 O O   . LEU A 1 261 ? 78.545  114.019 90.410  1.00 191.91 ? 261 LEU A O   1 
ATOM   1587 C CB  . LEU A 1 261 ? 78.502  111.554 92.232  1.00 183.00 ? 261 LEU A CB  1 
ATOM   1588 C CG  . LEU A 1 261 ? 77.654  110.593 93.067  1.00 197.30 ? 261 LEU A CG  1 
ATOM   1589 C CD1 . LEU A 1 261 ? 77.821  110.883 94.551  1.00 193.80 ? 261 LEU A CD1 1 
ATOM   1590 C CD2 . LEU A 1 261 ? 76.184  110.661 92.680  1.00 226.62 ? 261 LEU A CD2 1 
ATOM   1591 N N   . GLU A 1 262 ? 79.882  112.613 89.260  1.00 201.13 ? 262 GLU A N   1 
ATOM   1592 C CA  . GLU A 1 262 ? 80.697  113.698 88.716  1.00 209.96 ? 262 GLU A CA  1 
ATOM   1593 C C   . GLU A 1 262 ? 80.826  113.602 87.192  1.00 212.62 ? 262 GLU A C   1 
ATOM   1594 O O   . GLU A 1 262 ? 80.809  114.632 86.514  1.00 214.15 ? 262 GLU A O   1 
ATOM   1595 C CB  . GLU A 1 262 ? 82.055  113.752 89.424  1.00 210.40 ? 262 GLU A CB  1 
ATOM   1596 C CG  . GLU A 1 262 ? 82.968  114.882 88.958  1.00 237.10 ? 262 GLU A CG  1 
ATOM   1597 C CD  . GLU A 1 262 ? 82.388  116.287 89.058  1.00 237.91 ? 262 GLU A CD  1 
ATOM   1598 O OE1 . GLU A 1 262 ? 81.725  116.576 90.070  1.00 250.68 ? 262 GLU A OE1 1 
ATOM   1599 O OE2 . GLU A 1 262 ? 82.631  117.108 88.144  1.00 232.10 ? 262 GLU A OE2 1 
ATOM   1600 N N   . LYS A 1 263 ? 80.906  112.378 86.642  1.00 216.26 ? 263 LYS A N   1 
ATOM   1601 C CA  . LYS A 1 263 ? 80.921  112.195 85.194  1.00 232.47 ? 263 LYS A CA  1 
ATOM   1602 C C   . LYS A 1 263 ? 79.553  111.807 84.616  1.00 237.46 ? 263 LYS A C   1 
ATOM   1603 O O   . LYS A 1 263 ? 79.461  111.606 83.408  1.00 209.09 ? 263 LYS A O   1 
ATOM   1604 C CB  . LYS A 1 263 ? 82.019  111.210 84.771  1.00 224.31 ? 263 LYS A CB  1 
ATOM   1605 C CG  . LYS A 1 263 ? 83.093  111.809 83.877  1.00 244.28 ? 263 LYS A CG  1 
ATOM   1606 C CD  . LYS A 1 263 ? 83.707  113.101 84.395  1.00 250.36 ? 263 LYS A CD  1 
ATOM   1607 C CE  . LYS A 1 263 ? 84.786  113.646 83.479  1.00 244.50 ? 263 LYS A CE  1 
ATOM   1608 N NZ  . LYS A 1 263 ? 85.366  114.916 83.982  1.00 230.73 ? 263 LYS A NZ  1 
ATOM   1609 N N   . HIS A 1 264 ? 78.494  111.746 85.445  1.00 245.11 ? 264 HIS A N   1 
ATOM   1610 C CA  . HIS A 1 264 ? 77.109  111.661 84.983  1.00 242.42 ? 264 HIS A CA  1 
ATOM   1611 C C   . HIS A 1 264 ? 76.887  110.586 83.909  1.00 224.40 ? 264 HIS A C   1 
ATOM   1612 O O   . HIS A 1 264 ? 76.359  110.878 82.831  1.00 203.92 ? 264 HIS A O   1 
ATOM   1613 C CB  . HIS A 1 264 ? 76.640  113.037 84.489  1.00 267.41 ? 264 HIS A CB  1 
ATOM   1614 C CG  . HIS A 1 264 ? 76.841  114.144 85.476  1.00 285.48 ? 264 HIS A CG  1 
ATOM   1615 N ND1 . HIS A 1 264 ? 76.216  114.220 86.703  1.00 292.74 ? 264 HIS A ND1 1 
ATOM   1616 C CD2 . HIS A 1 264 ? 77.619  115.228 85.387  1.00 294.91 ? 264 HIS A CD2 1 
ATOM   1617 C CE1 . HIS A 1 264 ? 76.612  115.320 87.327  1.00 307.10 ? 264 HIS A CE1 1 
ATOM   1618 N NE2 . HIS A 1 264 ? 77.469  115.945 86.546  1.00 309.29 ? 264 HIS A NE2 1 
ATOM   1619 N N   . ASN A 1 265 ? 77.207  109.325 84.238  1.00 231.85 ? 265 ASN A N   1 
ATOM   1620 C CA  . ASN A 1 265 ? 76.991  108.212 83.320  1.00 225.16 ? 265 ASN A CA  1 
ATOM   1621 C C   . ASN A 1 265 ? 76.534  106.962 84.080  1.00 231.05 ? 265 ASN A C   1 
ATOM   1622 O O   . ASN A 1 265 ? 77.358  106.216 84.610  1.00 240.24 ? 265 ASN A O   1 
ATOM   1623 C CB  . ASN A 1 265 ? 78.248  107.950 82.485  1.00 215.12 ? 265 ASN A CB  1 
ATOM   1624 C CG  . ASN A 1 265 ? 77.986  107.067 81.284  1.00 226.41 ? 265 ASN A CG  1 
ATOM   1625 O OD1 . ASN A 1 265 ? 77.503  105.948 81.431  1.00 227.70 ? 265 ASN A OD1 1 
ATOM   1626 N ND2 . ASN A 1 265 ? 78.295  107.558 80.094  1.00 249.81 ? 265 ASN A ND2 1 
ATOM   1627 N N   . GLU A 1 266 ? 75.216  106.691 84.056  1.00 240.12 ? 266 GLU A N   1 
ATOM   1628 C CA  . GLU A 1 266 ? 74.623  105.584 84.798  1.00 251.00 ? 266 GLU A CA  1 
ATOM   1629 C C   . GLU A 1 266 ? 75.049  104.236 84.209  1.00 218.71 ? 266 GLU A C   1 
ATOM   1630 O O   . GLU A 1 266 ? 75.329  103.306 84.961  1.00 198.33 ? 266 GLU A O   1 
ATOM   1631 C CB  . GLU A 1 266 ? 73.097  105.714 84.828  1.00 298.81 ? 266 GLU A CB  1 
ATOM   1632 C CG  . GLU A 1 266 ? 72.410  104.622 85.635  1.00 320.83 ? 266 GLU A CG  1 
ATOM   1633 C CD  . GLU A 1 266 ? 70.917  104.812 85.850  1.00 333.17 ? 266 GLU A CD  1 
ATOM   1634 O OE1 . GLU A 1 266 ? 70.539  105.799 86.511  1.00 328.89 ? 266 GLU A OE1 1 
ATOM   1635 O OE2 . GLU A 1 266 ? 70.136  103.971 85.359  1.00 329.27 ? 266 GLU A OE2 1 
ATOM   1636 N N   . ALA A 1 267 ? 75.111  104.126 82.874  1.00 212.16 ? 267 ALA A N   1 
ATOM   1637 C CA  . ALA A 1 267 ? 75.443  102.868 82.216  1.00 225.66 ? 267 ALA A CA  1 
ATOM   1638 C C   . ALA A 1 267 ? 76.845  102.394 82.617  1.00 214.88 ? 267 ALA A C   1 
ATOM   1639 O O   . ALA A 1 267 ? 77.036  101.216 82.927  1.00 208.31 ? 267 ALA A O   1 
ATOM   1640 C CB  . ALA A 1 267 ? 75.300  103.018 80.717  1.00 246.74 ? 267 ALA A CB  1 
ATOM   1641 N N   . ARG A 1 268 ? 77.818  103.319 82.640  1.00 211.76 ? 268 ARG A N   1 
ATOM   1642 C CA  . ARG A 1 268 ? 79.173  103.022 83.085  1.00 200.50 ? 268 ARG A CA  1 
ATOM   1643 C C   . ARG A 1 268 ? 79.214  102.734 84.587  1.00 163.42 ? 268 ARG A C   1 
ATOM   1644 O O   . ARG A 1 268 ? 79.935  101.835 85.007  1.00 155.98 ? 268 ARG A O   1 
ATOM   1645 C CB  . ARG A 1 268 ? 80.127  104.169 82.731  1.00 213.26 ? 268 ARG A CB  1 
ATOM   1646 C CG  . ARG A 1 268 ? 80.455  104.269 81.249  1.00 216.20 ? 268 ARG A CG  1 
ATOM   1647 C CD  . ARG A 1 268 ? 81.475  105.361 80.989  1.00 231.37 ? 268 ARG A CD  1 
ATOM   1648 N NE  . ARG A 1 268 ? 81.937  105.393 79.611  1.00 257.15 ? 268 ARG A NE  1 
ATOM   1649 C CZ  . ARG A 1 268 ? 82.929  106.159 79.166  1.00 276.31 ? 268 ARG A CZ  1 
ATOM   1650 N NH1 . ARG A 1 268 ? 83.262  106.139 77.886  1.00 292.44 ? 268 ARG A NH1 1 
ATOM   1651 N NH2 . ARG A 1 268 ? 83.587  106.947 80.000  1.00 272.78 ? 268 ARG A NH2 1 
ATOM   1652 N N   . ALA A 1 269 ? 78.454  103.480 85.399  1.00 165.14 ? 269 ALA A N   1 
ATOM   1653 C CA  . ALA A 1 269 ? 78.396  103.239 86.835  1.00 162.07 ? 269 ALA A CA  1 
ATOM   1654 C C   . ALA A 1 269 ? 77.878  101.828 87.127  1.00 150.81 ? 269 ALA A C   1 
ATOM   1655 O O   . ALA A 1 269 ? 78.461  101.120 87.945  1.00 156.47 ? 269 ALA A O   1 
ATOM   1656 C CB  . ALA A 1 269 ? 77.556  104.302 87.512  1.00 182.27 ? 269 ALA A CB  1 
ATOM   1657 N N   . VAL A 1 270 ? 76.813  101.395 86.434  1.00 154.56 ? 270 VAL A N   1 
ATOM   1658 C CA  . VAL A 1 270 ? 76.272  100.049 86.579  1.00 161.50 ? 270 VAL A CA  1 
ATOM   1659 C C   . VAL A 1 270 ? 77.339  99.012  86.217  1.00 151.83 ? 270 VAL A C   1 
ATOM   1660 O O   . VAL A 1 270 ? 77.541  98.061  86.963  1.00 120.84 ? 270 VAL A O   1 
ATOM   1661 C CB  . VAL A 1 270 ? 74.972  99.871  85.762  1.00 180.29 ? 270 VAL A CB  1 
ATOM   1662 C CG1 . VAL A 1 270 ? 74.578  98.410  85.568  1.00 193.95 ? 270 VAL A CG1 1 
ATOM   1663 C CG2 . VAL A 1 270 ? 73.822  100.646 86.387  1.00 188.19 ? 270 VAL A CG2 1 
ATOM   1664 N N   . LYS A 1 271 ? 78.056  99.204  85.100  1.00 171.37 ? 271 LYS A N   1 
ATOM   1665 C CA  . LYS A 1 271 ? 79.113  98.288  84.691  1.00 197.10 ? 271 LYS A CA  1 
ATOM   1666 C C   . LYS A 1 271 ? 80.228  98.226  85.741  1.00 176.35 ? 271 LYS A C   1 
ATOM   1667 O O   . LYS A 1 271 ? 80.768  97.155  86.005  1.00 168.58 ? 271 LYS A O   1 
ATOM   1668 C CB  . LYS A 1 271 ? 79.669  98.693  83.320  1.00 254.66 ? 271 LYS A CB  1 
ATOM   1669 C CG  . LYS A 1 271 ? 80.734  97.762  82.753  1.00 289.07 ? 271 LYS A CG  1 
ATOM   1670 C CD  . LYS A 1 271 ? 81.281  98.218  81.418  1.00 319.72 ? 271 LYS A CD  1 
ATOM   1671 C CE  . LYS A 1 271 ? 82.395  97.330  80.907  1.00 347.83 ? 271 LYS A CE  1 
ATOM   1672 N NZ  . LYS A 1 271 ? 82.967  97.847  79.641  1.00 359.05 ? 271 LYS A NZ  1 
ATOM   1673 N N   . ALA A 1 272 ? 80.592  99.370  86.337  1.00 170.13 ? 272 ALA A N   1 
ATOM   1674 C CA  . ALA A 1 272 ? 81.615  99.427  87.374  1.00 146.47 ? 272 ALA A CA  1 
ATOM   1675 C C   . ALA A 1 272 ? 81.169  98.669  88.625  1.00 138.53 ? 272 ALA A C   1 
ATOM   1676 O O   . ALA A 1 272 ? 81.912  97.820  89.112  1.00 162.14 ? 272 ALA A O   1 
ATOM   1677 C CB  . ALA A 1 272 ? 81.968  100.863 87.676  1.00 141.18 ? 272 ALA A CB  1 
ATOM   1678 N N   . PHE A 1 273 ? 79.944  98.919  89.115  1.00 116.58 ? 273 PHE A N   1 
ATOM   1679 C CA  . PHE A 1 273 ? 79.400  98.187  90.252  1.00 127.62 ? 273 PHE A CA  1 
ATOM   1680 C C   . PHE A 1 273 ? 79.309  96.682  89.966  1.00 160.55 ? 273 PHE A C   1 
ATOM   1681 O O   . PHE A 1 273 ? 79.734  95.883  90.797  1.00 177.21 ? 273 PHE A O   1 
ATOM   1682 C CB  . PHE A 1 273 ? 78.023  98.720  90.646  1.00 140.69 ? 273 PHE A CB  1 
ATOM   1683 C CG  . PHE A 1 273 ? 77.982  100.000 91.447  1.00 155.24 ? 273 PHE A CG  1 
ATOM   1684 C CD1 . PHE A 1 273 ? 78.629  100.103 92.673  1.00 151.58 ? 273 PHE A CD1 1 
ATOM   1685 C CD2 . PHE A 1 273 ? 77.226  101.084 91.000  1.00 137.68 ? 273 PHE A CD2 1 
ATOM   1686 C CE1 . PHE A 1 273 ? 78.534  101.272 93.417  1.00 168.72 ? 273 PHE A CE1 1 
ATOM   1687 C CE2 . PHE A 1 273 ? 77.135  102.251 91.740  1.00 105.66 ? 273 PHE A CE2 1 
ATOM   1688 C CZ  . PHE A 1 273 ? 77.787  102.342 92.946  1.00 141.84 ? 273 PHE A CZ  1 
ATOM   1689 N N   . GLN A 1 274 ? 78.753  96.280  88.811  1.00 161.66 ? 274 GLN A N   1 
ATOM   1690 C CA  . GLN A 1 274 ? 78.605  94.868  88.465  1.00 168.38 ? 274 GLN A CA  1 
ATOM   1691 C C   . GLN A 1 274 ? 79.958  94.156  88.396  1.00 136.37 ? 274 GLN A C   1 
ATOM   1692 O O   . GLN A 1 274 ? 80.059  92.997  88.780  1.00 139.30 ? 274 GLN A O   1 
ATOM   1693 C CB  . GLN A 1 274 ? 77.863  94.698  87.134  1.00 204.96 ? 274 GLN A CB  1 
ATOM   1694 C CG  . GLN A 1 274 ? 76.359  94.925  87.231  1.00 230.77 ? 274 GLN A CG  1 
ATOM   1695 C CD  . GLN A 1 274 ? 75.665  94.816  85.892  1.00 258.12 ? 274 GLN A CD  1 
ATOM   1696 O OE1 . GLN A 1 274 ? 76.224  95.152  84.849  1.00 249.83 ? 274 GLN A OE1 1 
ATOM   1697 N NE2 . GLN A 1 274 ? 74.429  94.339  85.910  1.00 281.14 ? 274 GLN A NE2 1 
ATOM   1698 N N   . THR A 1 275 ? 80.994  94.842  87.892  1.00 130.68 ? 275 THR A N   1 
ATOM   1699 C CA  . THR A 1 275 ? 82.319  94.261  87.723  1.00 140.76 ? 275 THR A CA  1 
ATOM   1700 C C   . THR A 1 275 ? 83.011  94.039  89.071  1.00 130.43 ? 275 THR A C   1 
ATOM   1701 O O   . THR A 1 275 ? 83.646  93.002  89.253  1.00 152.16 ? 275 THR A O   1 
ATOM   1702 C CB  . THR A 1 275 ? 83.187  95.108  86.781  1.00 169.58 ? 275 THR A CB  1 
ATOM   1703 O OG1 . THR A 1 275 ? 82.531  95.220  85.516  1.00 187.79 ? 275 THR A OG1 1 
ATOM   1704 C CG2 . THR A 1 275 ? 84.562  94.516  86.554  1.00 188.04 ? 275 THR A CG2 1 
ATOM   1705 N N   . PHE A 1 276 ? 82.911  94.997  90.008  1.00 114.66 ? 276 PHE A N   1 
ATOM   1706 C CA  . PHE A 1 276 ? 83.560  94.875  91.310  1.00 126.93 ? 276 PHE A CA  1 
ATOM   1707 C C   . PHE A 1 276 ? 82.757  93.995  92.276  1.00 141.28 ? 276 PHE A C   1 
ATOM   1708 O O   . PHE A 1 276 ? 83.342  93.157  92.956  1.00 132.66 ? 276 PHE A O   1 
ATOM   1709 C CB  . PHE A 1 276 ? 83.846  96.256  91.911  1.00 124.53 ? 276 PHE A CB  1 
ATOM   1710 C CG  . PHE A 1 276 ? 84.928  97.028  91.196  1.00 138.16 ? 276 PHE A CG  1 
ATOM   1711 C CD1 . PHE A 1 276 ? 86.198  96.495  91.046  1.00 150.03 ? 276 PHE A CD1 1 
ATOM   1712 C CD2 . PHE A 1 276 ? 84.683  98.288  90.677  1.00 142.99 ? 276 PHE A CD2 1 
ATOM   1713 C CE1 . PHE A 1 276 ? 87.192  97.207  90.389  1.00 147.20 ? 276 PHE A CE1 1 
ATOM   1714 C CE2 . PHE A 1 276 ? 85.675  98.990  90.014  1.00 141.12 ? 276 PHE A CE2 1 
ATOM   1715 C CZ  . PHE A 1 276 ? 86.920  98.440  89.854  1.00 138.05 ? 276 PHE A CZ  1 
ATOM   1716 N N   . LEU A 1 277 ? 81.429  94.186  92.357  1.00 152.51 ? 277 LEU A N   1 
ATOM   1717 C CA  . LEU A 1 277 ? 80.602  93.474  93.326  1.00 160.30 ? 277 LEU A CA  1 
ATOM   1718 C C   . LEU A 1 277 ? 80.350  92.024  92.896  1.00 158.22 ? 277 LEU A C   1 
ATOM   1719 O O   . LEU A 1 277 ? 80.072  91.175  93.747  1.00 191.73 ? 277 LEU A O   1 
ATOM   1720 C CB  . LEU A 1 277 ? 79.277  94.225  93.521  1.00 174.23 ? 277 LEU A CB  1 
ATOM   1721 C CG  . LEU A 1 277 ? 79.383  95.658  94.052  1.00 194.10 ? 277 LEU A CG  1 
ATOM   1722 C CD1 . LEU A 1 277 ? 78.007  96.288  94.209  1.00 200.97 ? 277 LEU A CD1 1 
ATOM   1723 C CD2 . LEU A 1 277 ? 80.137  95.702  95.377  1.00 189.74 ? 277 LEU A CD2 1 
ATOM   1724 N N   . GLY A 1 278 ? 80.395  91.741  91.590  1.00 149.75 ? 278 GLY A N   1 
ATOM   1725 C CA  . GLY A 1 278 ? 80.295  90.379  91.078  1.00 190.04 ? 278 GLY A CA  1 
ATOM   1726 C C   . GLY A 1 278 ? 78.895  89.769  91.198  1.00 212.62 ? 278 GLY A C   1 
ATOM   1727 O O   . GLY A 1 278 ? 78.773  88.554  91.365  1.00 229.77 ? 278 GLY A O   1 
ATOM   1728 N N   . LYS A 1 279 ? 77.851  90.611  91.079  1.00 207.69 ? 279 LYS A N   1 
ATOM   1729 C CA  . LYS A 1 279 ? 76.463  90.166  91.178  1.00 225.57 ? 279 LYS A CA  1 
ATOM   1730 C C   . LYS A 1 279 ? 75.580  90.871  90.139  1.00 246.80 ? 279 LYS A C   1 
ATOM   1731 O O   . LYS A 1 279 ? 75.969  91.881  89.559  1.00 247.86 ? 279 LYS A O   1 
ATOM   1732 C CB  . LYS A 1 279 ? 75.944  90.355  92.611  1.00 238.13 ? 279 LYS A CB  1 
ATOM   1733 C CG  . LYS A 1 279 ? 75.792  91.789  93.108  1.00 242.38 ? 279 LYS A CG  1 
ATOM   1734 C CD  . LYS A 1 279 ? 75.525  91.857  94.602  1.00 251.01 ? 279 LYS A CD  1 
ATOM   1735 C CE  . LYS A 1 279 ? 75.281  93.255  95.129  1.00 241.86 ? 279 LYS A CE  1 
ATOM   1736 N NZ  . LYS A 1 279 ? 73.887  93.702  94.903  1.00 231.04 ? 279 LYS A NZ  1 
ATOM   1737 N N   . ALA A 1 280 ? 74.370  90.328  89.929  1.00 270.29 ? 280 ALA A N   1 
ATOM   1738 C CA  . ALA A 1 280 ? 73.504  90.693  88.814  1.00 288.85 ? 280 ALA A CA  1 
ATOM   1739 C C   . ALA A 1 280 ? 72.937  92.110  88.959  1.00 283.70 ? 280 ALA A C   1 
ATOM   1740 O O   . ALA A 1 280 ? 73.090  92.928  88.051  1.00 276.13 ? 280 ALA A O   1 
ATOM   1741 C CB  . ALA A 1 280 ? 72.395  89.672  88.682  1.00 307.91 ? 280 ALA A CB  1 
ATOM   1742 N N   . ASP A 1 281 ? 72.268  92.401  90.090  1.00 283.33 ? 281 ASP A N   1 
ATOM   1743 C CA  . ASP A 1 281 ? 71.608  93.688  90.301  1.00 274.28 ? 281 ASP A CA  1 
ATOM   1744 C C   . ASP A 1 281 ? 72.455  94.595  91.197  1.00 255.71 ? 281 ASP A C   1 
ATOM   1745 O O   . ASP A 1 281 ? 72.900  94.194  92.276  1.00 268.42 ? 281 ASP A O   1 
ATOM   1746 C CB  . ASP A 1 281 ? 70.198  93.524  90.884  1.00 282.70 ? 281 ASP A CB  1 
ATOM   1747 C CG  . ASP A 1 281 ? 69.505  94.845  91.193  1.00 275.43 ? 281 ASP A CG  1 
ATOM   1748 O OD1 . ASP A 1 281 ? 69.709  95.802  90.416  1.00 269.44 ? 281 ASP A OD1 1 
ATOM   1749 O OD2 . ASP A 1 281 ? 68.766  94.909  92.207  1.00 275.43 ? 281 ASP A OD2 1 
ATOM   1750 N N   . VAL A 1 282 ? 72.626  95.849  90.742  1.00 216.36 ? 282 VAL A N   1 
ATOM   1751 C CA  . VAL A 1 282 ? 73.374  96.868  91.469  1.00 196.78 ? 282 VAL A CA  1 
ATOM   1752 C C   . VAL A 1 282 ? 72.568  98.164  91.607  1.00 208.32 ? 282 VAL A C   1 
ATOM   1753 O O   . VAL A 1 282 ? 73.096  99.153  92.117  1.00 212.46 ? 282 VAL A O   1 
ATOM   1754 C CB  . VAL A 1 282 ? 74.726  97.140  90.784  1.00 192.81 ? 282 VAL A CB  1 
ATOM   1755 C CG1 . VAL A 1 282 ? 75.578  95.882  90.737  1.00 201.78 ? 282 VAL A CG1 1 
ATOM   1756 C CG2 . VAL A 1 282 ? 74.558  97.724  89.387  1.00 206.05 ? 282 VAL A CG2 1 
ATOM   1757 N N   . SER A 1 283 ? 71.288  98.148  91.192  1.00 231.85 ? 283 SER A N   1 
ATOM   1758 C CA  . SER A 1 283 ? 70.401  99.307  91.247  1.00 254.68 ? 283 SER A CA  1 
ATOM   1759 C C   . SER A 1 283 ? 70.276  99.849  92.672  1.00 260.49 ? 283 SER A C   1 
ATOM   1760 O O   . SER A 1 283 ? 69.979  101.029 92.864  1.00 262.36 ? 283 SER A O   1 
ATOM   1761 C CB  . SER A 1 283 ? 69.035  98.957  90.704  1.00 273.98 ? 283 SER A CB  1 
ATOM   1762 O OG  . SER A 1 283 ? 69.132  98.210  89.497  1.00 290.97 ? 283 SER A OG  1 
ATOM   1763 N N   . GLN A 1 284 ? 70.491  98.967  93.660  1.00 241.34 ? 284 GLN A N   1 
ATOM   1764 C CA  . GLN A 1 284 ? 70.399  99.293  95.076  1.00 219.82 ? 284 GLN A CA  1 
ATOM   1765 C C   . GLN A 1 284 ? 71.520  100.257 95.471  1.00 211.30 ? 284 GLN A C   1 
ATOM   1766 O O   . GLN A 1 284 ? 71.254  101.270 96.115  1.00 223.13 ? 284 GLN A O   1 
ATOM   1767 C CB  . GLN A 1 284 ? 70.429  98.005  95.909  1.00 235.83 ? 284 GLN A CB  1 
ATOM   1768 C CG  . GLN A 1 284 ? 69.544  96.873  95.380  1.00 262.09 ? 284 GLN A CG  1 
ATOM   1769 C CD  . GLN A 1 284 ? 68.125  97.292  95.069  1.00 285.78 ? 284 GLN A CD  1 
ATOM   1770 O OE1 . GLN A 1 284 ? 67.512  98.061  95.807  1.00 293.76 ? 284 GLN A OE1 1 
ATOM   1771 N NE2 . GLN A 1 284 ? 67.587  96.786  93.968  1.00 294.62 ? 284 GLN A NE2 1 
ATOM   1772 N N   . GLU A 1 285 ? 72.764  99.957  95.064  1.00 225.86 ? 285 GLU A N   1 
ATOM   1773 C CA  . GLU A 1 285 ? 73.906  100.833 95.308  1.00 220.82 ? 285 GLU A CA  1 
ATOM   1774 C C   . GLU A 1 285 ? 73.811  102.110 94.468  1.00 169.59 ? 285 GLU A C   1 
ATOM   1775 O O   . GLU A 1 285 ? 74.145  103.184 94.964  1.00 142.92 ? 285 GLU A O   1 
ATOM   1776 C CB  . GLU A 1 285 ? 75.231  100.111 95.041  1.00 235.88 ? 285 GLU A CB  1 
ATOM   1777 C CG  . GLU A 1 285 ? 75.769  99.350  96.244  1.00 236.75 ? 285 GLU A CG  1 
ATOM   1778 C CD  . GLU A 1 285 ? 76.295  100.223 97.377  1.00 230.60 ? 285 GLU A CD  1 
ATOM   1779 O OE1 . GLU A 1 285 ? 77.490  100.621 97.341  1.00 221.91 ? 285 GLU A OE1 1 
ATOM   1780 O OE2 . GLU A 1 285 ? 75.490  100.538 98.277  1.00 216.59 ? 285 GLU A OE2 1 
ATOM   1781 N N   . VAL A 1 286 ? 73.363  101.998 93.208  1.00 160.24 ? 286 VAL A N   1 
ATOM   1782 C CA  . VAL A 1 286 ? 73.176  103.154 92.340  1.00 177.90 ? 286 VAL A CA  1 
ATOM   1783 C C   . VAL A 1 286 ? 72.198  104.136 92.992  1.00 189.59 ? 286 VAL A C   1 
ATOM   1784 O O   . VAL A 1 286 ? 72.483  105.332 93.069  1.00 192.11 ? 286 VAL A O   1 
ATOM   1785 C CB  . VAL A 1 286 ? 72.730  102.737 90.920  1.00 198.95 ? 286 VAL A CB  1 
ATOM   1786 C CG1 . VAL A 1 286 ? 72.335  103.925 90.047  1.00 203.98 ? 286 VAL A CG1 1 
ATOM   1787 C CG2 . VAL A 1 286 ? 73.795  101.915 90.215  1.00 199.96 ? 286 VAL A CG2 1 
ATOM   1788 N N   . GLU A 1 287 ? 71.059  103.638 93.492  1.00 200.52 ? 287 GLU A N   1 
ATOM   1789 C CA  . GLU A 1 287 ? 70.088  104.490 94.163  1.00 223.96 ? 287 GLU A CA  1 
ATOM   1790 C C   . GLU A 1 287 ? 70.656  105.012 95.486  1.00 221.94 ? 287 GLU A C   1 
ATOM   1791 O O   . GLU A 1 287 ? 70.436  106.174 95.822  1.00 234.05 ? 287 GLU A O   1 
ATOM   1792 C CB  . GLU A 1 287 ? 68.761  103.757 94.376  1.00 257.60 ? 287 GLU A CB  1 
ATOM   1793 C CG  . GLU A 1 287 ? 67.634  104.654 94.873  1.00 304.92 ? 287 GLU A CG  1 
ATOM   1794 C CD  . GLU A 1 287 ? 67.311  105.860 94.000  1.00 352.04 ? 287 GLU A CD  1 
ATOM   1795 O OE1 . GLU A 1 287 ? 67.375  105.715 92.761  1.00 358.05 ? 287 GLU A OE1 1 
ATOM   1796 O OE2 . GLU A 1 287 ? 66.961  106.930 94.555  1.00 391.41 ? 287 GLU A OE2 1 
ATOM   1797 N N   . GLU A 1 288 ? 71.391  104.180 96.239  1.00 203.74 ? 288 GLU A N   1 
ATOM   1798 C CA  . GLU A 1 288 ? 71.947  104.603 97.520  1.00 191.77 ? 288 GLU A CA  1 
ATOM   1799 C C   . GLU A 1 288 ? 72.880  105.795 97.325  1.00 177.29 ? 288 GLU A C   1 
ATOM   1800 O O   . GLU A 1 288 ? 72.721  106.817 97.991  1.00 192.62 ? 288 GLU A O   1 
ATOM   1801 C CB  . GLU A 1 288 ? 72.688  103.459 98.217  1.00 191.80 ? 288 GLU A CB  1 
ATOM   1802 C CG  . GLU A 1 288 ? 73.199  103.796 99.605  1.00 216.30 ? 288 GLU A CG  1 
ATOM   1803 C CD  . GLU A 1 288 ? 74.711  103.901 99.722  1.00 260.30 ? 288 GLU A CD  1 
ATOM   1804 O OE1 . GLU A 1 288 ? 75.270  104.968 99.383  1.00 283.07 ? 288 GLU A OE1 1 
ATOM   1805 O OE2 . GLU A 1 288 ? 75.328  102.903 100.142 1.00 280.62 ? 288 GLU A OE2 1 
ATOM   1806 N N   . VAL A 1 289 ? 73.835  105.656 96.399  1.00 159.11 ? 289 VAL A N   1 
ATOM   1807 C CA  . VAL A 1 289 ? 74.823  106.688 96.113  1.00 163.73 ? 289 VAL A CA  1 
ATOM   1808 C C   . VAL A 1 289 ? 74.134  107.981 95.666  1.00 171.96 ? 289 VAL A C   1 
ATOM   1809 O O   . VAL A 1 289 ? 74.504  109.063 96.121  1.00 173.08 ? 289 VAL A O   1 
ATOM   1810 C CB  . VAL A 1 289 ? 75.861  106.178 95.090  1.00 153.58 ? 289 VAL A CB  1 
ATOM   1811 C CG1 . VAL A 1 289 ? 76.665  107.296 94.438  1.00 140.63 ? 289 VAL A CG1 1 
ATOM   1812 C CG2 . VAL A 1 289 ? 76.796  105.159 95.725  1.00 148.68 ? 289 VAL A CG2 1 
ATOM   1813 N N   . LEU A 1 290 ? 73.116  107.883 94.799  1.00 174.98 ? 290 LEU A N   1 
ATOM   1814 C CA  . LEU A 1 290 ? 72.357  109.057 94.389  1.00 183.58 ? 290 LEU A CA  1 
ATOM   1815 C C   . LEU A 1 290 ? 71.574  109.644 95.568  1.00 207.66 ? 290 LEU A C   1 
ATOM   1816 O O   . LEU A 1 290 ? 71.521  110.863 95.694  1.00 224.58 ? 290 LEU A O   1 
ATOM   1817 C CB  . LEU A 1 290 ? 71.439  108.696 93.216  1.00 200.88 ? 290 LEU A CB  1 
ATOM   1818 C CG  . LEU A 1 290 ? 72.146  108.472 91.881  1.00 229.57 ? 290 LEU A CG  1 
ATOM   1819 C CD1 . LEU A 1 290 ? 71.188  107.878 90.859  1.00 255.84 ? 290 LEU A CD1 1 
ATOM   1820 C CD2 . LEU A 1 290 ? 72.746  109.769 91.355  1.00 229.47 ? 290 LEU A CD2 1 
ATOM   1821 N N   . ALA A 1 291 ? 70.997  108.801 96.441  1.00 211.65 ? 291 ALA A N   1 
ATOM   1822 C CA  . ALA A 1 291 ? 70.291  109.258 97.633  1.00 229.54 ? 291 ALA A CA  1 
ATOM   1823 C C   . ALA A 1 291 ? 71.225  110.006 98.588  1.00 227.55 ? 291 ALA A C   1 
ATOM   1824 O O   . ALA A 1 291 ? 70.865  111.065 99.109  1.00 235.02 ? 291 ALA A O   1 
ATOM   1825 C CB  . ALA A 1 291 ? 69.621  108.088 98.319  1.00 243.66 ? 291 ALA A CB  1 
ATOM   1826 N N   . GLU A 1 292 ? 72.425  109.459 98.826  1.00 202.48 ? 292 GLU A N   1 
ATOM   1827 C CA  . GLU A 1 292 ? 73.415  110.147 99.642  1.00 197.89 ? 292 GLU A CA  1 
ATOM   1828 C C   . GLU A 1 292 ? 73.701  111.514 99.022  1.00 201.74 ? 292 GLU A C   1 
ATOM   1829 O O   . GLU A 1 292 ? 73.652  112.528 99.714  1.00 223.93 ? 292 GLU A O   1 
ATOM   1830 C CB  . GLU A 1 292 ? 74.697  109.322 99.760  1.00 220.62 ? 292 GLU A CB  1 
ATOM   1831 C CG  . GLU A 1 292 ? 75.316  109.318 101.146 1.00 249.08 ? 292 GLU A CG  1 
ATOM   1832 C CD  . GLU A 1 292 ? 76.114  108.059 101.439 1.00 277.54 ? 292 GLU A CD  1 
ATOM   1833 O OE1 . GLU A 1 292 ? 77.007  107.721 100.633 1.00 285.19 ? 292 GLU A OE1 1 
ATOM   1834 O OE2 . GLU A 1 292 ? 75.831  107.409 102.465 1.00 290.93 ? 292 GLU A OE2 1 
ATOM   1835 N N   . SER A 1 293 ? 73.964  111.533 97.710  1.00 199.34 ? 293 SER A N   1 
ATOM   1836 C CA  . SER A 1 293 ? 74.215  112.774 96.992  1.00 217.25 ? 293 SER A CA  1 
ATOM   1837 C C   . SER A 1 293 ? 73.046  113.757 97.134  1.00 260.70 ? 293 SER A C   1 
ATOM   1838 O O   . SER A 1 293 ? 73.292  114.938 97.358  1.00 282.15 ? 293 SER A O   1 
ATOM   1839 C CB  . SER A 1 293 ? 74.557  112.518 95.543  1.00 226.72 ? 293 SER A CB  1 
ATOM   1840 O OG  . SER A 1 293 ? 74.806  113.737 94.856  1.00 232.87 ? 293 SER A OG  1 
ATOM   1841 N N   . ARG A 1 294 ? 71.786  113.294 97.042  1.00 283.83 ? 294 ARG A N   1 
ATOM   1842 C CA  . ARG A 1 294 ? 70.621  114.171 97.171  1.00 297.14 ? 294 ARG A CA  1 
ATOM   1843 C C   . ARG A 1 294 ? 70.606  114.886 98.529  1.00 302.02 ? 294 ARG A C   1 
ATOM   1844 O O   . ARG A 1 294 ? 70.148  116.027 98.613  1.00 290.52 ? 294 ARG A O   1 
ATOM   1845 C CB  . ARG A 1 294 ? 69.309  113.407 96.932  1.00 301.08 ? 294 ARG A CB  1 
ATOM   1846 C CG  . ARG A 1 294 ? 69.025  113.103 95.466  1.00 313.96 ? 294 ARG A CG  1 
ATOM   1847 C CD  . ARG A 1 294 ? 67.663  112.482 95.181  1.00 326.41 ? 294 ARG A CD  1 
ATOM   1848 N NE  . ARG A 1 294 ? 67.348  111.298 95.979  1.00 327.58 ? 294 ARG A NE  1 
ATOM   1849 C CZ  . ARG A 1 294 ? 67.246  110.049 95.518  1.00 324.15 ? 294 ARG A CZ  1 
ATOM   1850 N NH1 . ARG A 1 294 ? 66.827  109.086 96.319  1.00 317.42 ? 294 ARG A NH1 1 
ATOM   1851 N NH2 . ARG A 1 294 ? 67.543  109.755 94.262  1.00 323.61 ? 294 ARG A NH2 1 
ATOM   1852 N N   . VAL A 1 295 ? 71.098  114.221 99.589  1.00 304.35 ? 295 VAL A N   1 
ATOM   1853 C CA  . VAL A 1 295 ? 71.330  114.855 100.883 1.00 301.71 ? 295 VAL A CA  1 
ATOM   1854 C C   . VAL A 1 295 ? 72.553  115.778 100.800 1.00 294.53 ? 295 VAL A C   1 
ATOM   1855 O O   . VAL A 1 295 ? 72.431  116.982 101.033 1.00 293.34 ? 295 VAL A O   1 
ATOM   1856 C CB  . VAL A 1 295 ? 71.471  113.801 102.005 1.00 295.22 ? 295 VAL A CB  1 
ATOM   1857 C CG1 . VAL A 1 295 ? 71.914  114.406 103.333 1.00 283.84 ? 295 VAL A CG1 1 
ATOM   1858 C CG2 . VAL A 1 295 ? 70.185  113.011 102.196 1.00 300.04 ? 295 VAL A CG2 1 
ATOM   1859 N N   . GLN A 1 296 ? 73.719  115.219 100.432 1.00 284.57 ? 296 GLN A N   1 
ATOM   1860 C CA  . GLN A 1 296 ? 75.017  115.879 100.538 1.00 274.72 ? 296 GLN A CA  1 
ATOM   1861 C C   . GLN A 1 296 ? 75.112  117.150 99.682  1.00 269.54 ? 296 GLN A C   1 
ATOM   1862 O O   . GLN A 1 296 ? 75.811  118.086 100.066 1.00 261.74 ? 296 GLN A O   1 
ATOM   1863 C CB  . GLN A 1 296 ? 76.111  114.864 100.181 1.00 301.85 ? 296 GLN A CB  1 
ATOM   1864 C CG  . GLN A 1 296 ? 77.530  115.426 100.182 1.00 323.10 ? 296 GLN A CG  1 
ATOM   1865 C CD  . GLN A 1 296 ? 78.601  114.359 100.224 1.00 336.31 ? 296 GLN A CD  1 
ATOM   1866 O OE1 . GLN A 1 296 ? 79.577  114.467 100.967 1.00 342.77 ? 296 GLN A OE1 1 
ATOM   1867 N NE2 . GLN A 1 296 ? 78.437  113.323 99.415  1.00 331.62 ? 296 GLN A NE2 1 
ATOM   1868 N N   . ARG A 1 297 ? 74.408  117.203 98.540  1.00 287.18 ? 297 ARG A N   1 
ATOM   1869 C CA  . ARG A 1 297 ? 74.492  118.322 97.603  1.00 314.18 ? 297 ARG A CA  1 
ATOM   1870 C C   . ARG A 1 297 ? 73.892  119.609 98.190  1.00 315.17 ? 297 ARG A C   1 
ATOM   1871 O O   . ARG A 1 297 ? 74.140  120.697 97.667  1.00 323.68 ? 297 ARG A O   1 
ATOM   1872 C CB  . ARG A 1 297 ? 73.806  117.916 96.292  1.00 348.80 ? 297 ARG A CB  1 
ATOM   1873 C CG  . ARG A 1 297 ? 74.044  118.849 95.114  1.00 382.81 ? 297 ARG A CG  1 
ATOM   1874 C CD  . ARG A 1 297 ? 73.609  118.205 93.809  1.00 410.72 ? 297 ARG A CD  1 
ATOM   1875 N NE  . ARG A 1 297 ? 72.200  117.829 93.815  1.00 434.11 ? 297 ARG A NE  1 
ATOM   1876 C CZ  . ARG A 1 297 ? 71.621  117.031 92.922  1.00 446.31 ? 297 ARG A CZ  1 
ATOM   1877 N NH1 . ARG A 1 297 ? 70.330  116.762 93.014  1.00 449.38 ? 297 ARG A NH1 1 
ATOM   1878 N NH2 . ARG A 1 297 ? 72.331  116.500 91.940  1.00 445.86 ? 297 ARG A NH2 1 
ATOM   1879 N N   . SER A 1 298 ? 73.113  119.490 99.281  1.00 309.69 ? 298 SER A N   1 
ATOM   1880 C CA  . SER A 1 298 ? 72.507  120.626 99.972  1.00 299.11 ? 298 SER A CA  1 
ATOM   1881 C C   . SER A 1 298 ? 73.462  121.284 100.974 1.00 267.95 ? 298 SER A C   1 
ATOM   1882 O O   . SER A 1 298 ? 73.191  122.393 101.432 1.00 248.14 ? 298 SER A O   1 
ATOM   1883 C CB  . SER A 1 298 ? 71.234  120.199 100.671 1.00 309.72 ? 298 SER A CB  1 
ATOM   1884 O OG  . SER A 1 298 ? 71.519  119.375 101.795 1.00 314.64 ? 298 SER A OG  1 
ATOM   1885 N N   . ILE A 1 299 ? 74.573  120.607 101.315 1.00 253.11 ? 299 ILE A N   1 
ATOM   1886 C CA  . ILE A 1 299 ? 75.436  120.981 102.432 1.00 254.45 ? 299 ILE A CA  1 
ATOM   1887 C C   . ILE A 1 299 ? 76.358  122.146 102.052 1.00 226.08 ? 299 ILE A C   1 
ATOM   1888 O O   . ILE A 1 299 ? 77.005  122.125 101.006 1.00 199.83 ? 299 ILE A O   1 
ATOM   1889 C CB  . ILE A 1 299 ? 76.241  119.748 102.909 1.00 301.25 ? 299 ILE A CB  1 
ATOM   1890 C CG1 . ILE A 1 299 ? 75.317  118.633 103.414 1.00 337.39 ? 299 ILE A CG1 1 
ATOM   1891 C CG2 . ILE A 1 299 ? 77.289  120.126 103.953 1.00 310.17 ? 299 ILE A CG2 1 
ATOM   1892 C CD1 . ILE A 1 299 ? 76.039  117.372 103.854 1.00 345.30 ? 299 ILE A CD1 1 
ATOM   1893 N N   . ARG A 1 300 ? 76.445  123.149 102.944 1.00 217.01 ? 300 ARG A N   1 
ATOM   1894 C CA  . ARG A 1 300 ? 77.475  124.178 102.881 1.00 190.09 ? 300 ARG A CA  1 
ATOM   1895 C C   . ARG A 1 300 ? 78.777  123.613 103.454 1.00 156.53 ? 300 ARG A C   1 
ATOM   1896 O O   . ARG A 1 300 ? 78.835  123.207 104.617 1.00 197.89 ? 300 ARG A O   1 
ATOM   1897 C CB  . ARG A 1 300 ? 77.042  125.427 103.663 1.00 215.13 ? 300 ARG A CB  1 
ATOM   1898 C CG  . ARG A 1 300 ? 77.976  126.621 103.516 1.00 247.85 ? 300 ARG A CG  1 
ATOM   1899 C CD  . ARG A 1 300 ? 77.631  127.803 104.414 1.00 292.27 ? 300 ARG A CD  1 
ATOM   1900 N NE  . ARG A 1 300 ? 78.101  127.687 105.795 1.00 316.58 ? 300 ARG A NE  1 
ATOM   1901 C CZ  . ARG A 1 300 ? 79.294  128.078 106.248 1.00 320.79 ? 300 ARG A CZ  1 
ATOM   1902 N NH1 . ARG A 1 300 ? 79.603  127.909 107.523 1.00 314.91 ? 300 ARG A NH1 1 
ATOM   1903 N NH2 . ARG A 1 300 ? 80.179  128.644 105.442 1.00 321.16 ? 300 ARG A NH2 1 
ATOM   1904 N N   . LEU A 1 301 ? 79.831  123.590 102.626 1.00 141.66 ? 301 LEU A N   1 
ATOM   1905 C CA  . LEU A 1 301 ? 81.160  123.193 103.074 1.00 139.27 ? 301 LEU A CA  1 
ATOM   1906 C C   . LEU A 1 301 ? 81.781  124.301 103.924 1.00 123.42 ? 301 LEU A C   1 
ATOM   1907 O O   . LEU A 1 301 ? 81.519  125.483 103.696 1.00 126.80 ? 301 LEU A O   1 
ATOM   1908 C CB  . LEU A 1 301 ? 82.040  122.911 101.849 1.00 161.11 ? 301 LEU A CB  1 
ATOM   1909 C CG  . LEU A 1 301 ? 81.718  121.637 101.068 1.00 180.92 ? 301 LEU A CG  1 
ATOM   1910 C CD1 . LEU A 1 301 ? 82.540  121.587 99.786  1.00 201.58 ? 301 LEU A CD1 1 
ATOM   1911 C CD2 . LEU A 1 301 ? 81.957  120.387 101.917 1.00 172.27 ? 301 LEU A CD2 1 
ATOM   1912 N N   . VAL A 1 302 ? 82.633  123.898 104.880 1.00 125.45 ? 302 VAL A N   1 
ATOM   1913 C CA  . VAL A 1 302 ? 83.369  124.823 105.735 1.00 131.96 ? 302 VAL A CA  1 
ATOM   1914 C C   . VAL A 1 302 ? 84.803  124.928 105.213 1.00 114.34 ? 302 VAL A C   1 
ATOM   1915 O O   . VAL A 1 302 ? 85.417  123.920 104.879 1.00 92.98  ? 302 VAL A O   1 
ATOM   1916 C CB  . VAL A 1 302 ? 83.312  124.383 107.220 1.00 158.79 ? 302 VAL A CB  1 
ATOM   1917 C CG1 . VAL A 1 302 ? 84.093  125.289 108.154 1.00 158.07 ? 302 VAL A CG1 1 
ATOM   1918 C CG2 . VAL A 1 302 ? 81.884  124.275 107.728 1.00 171.73 ? 302 VAL A CG2 1 
ATOM   1919 N N   . SER A 1 303 ? 85.334  126.162 105.174 1.00 135.73 ? 303 SER A N   1 
ATOM   1920 C CA  . SER A 1 303 ? 86.684  126.436 104.689 1.00 133.25 ? 303 SER A CA  1 
ATOM   1921 C C   . SER A 1 303 ? 87.717  126.238 105.806 1.00 120.35 ? 303 SER A C   1 
ATOM   1922 O O   . SER A 1 303 ? 87.403  126.365 106.990 1.00 119.80 ? 303 SER A O   1 
ATOM   1923 C CB  . SER A 1 303 ? 86.754  127.835 104.098 1.00 162.66 ? 303 SER A CB  1 
ATOM   1924 O OG  . SER A 1 303 ? 86.423  128.840 105.049 1.00 145.68 ? 303 SER A OG  1 
ATOM   1925 N N   . VAL A 1 304 ? 88.983  125.961 105.443 1.00 108.77 ? 304 VAL A N   1 
ATOM   1926 C CA  . VAL A 1 304 ? 90.007  125.568 106.414 1.00 102.37 ? 304 VAL A CA  1 
ATOM   1927 C C   . VAL A 1 304 ? 90.223  126.652 107.478 1.00 90.85  ? 304 VAL A C   1 
ATOM   1928 O O   . VAL A 1 304 ? 90.338  126.348 108.659 1.00 72.55  ? 304 VAL A O   1 
ATOM   1929 C CB  . VAL A 1 304 ? 91.319  125.182 105.703 1.00 102.52 ? 304 VAL A CB  1 
ATOM   1930 C CG1 . VAL A 1 304 ? 92.417  124.823 106.677 1.00 108.06 ? 304 VAL A CG1 1 
ATOM   1931 C CG2 . VAL A 1 304 ? 91.122  124.042 104.721 1.00 107.40 ? 304 VAL A CG2 1 
ATOM   1932 N N   . LEU A 1 305 ? 90.239  127.918 107.048 1.00 118.56 ? 305 LEU A N   1 
ATOM   1933 C CA  . LEU A 1 305 ? 90.498  129.081 107.897 1.00 128.76 ? 305 LEU A CA  1 
ATOM   1934 C C   . LEU A 1 305 ? 89.341  129.365 108.860 1.00 130.68 ? 305 LEU A C   1 
ATOM   1935 O O   . LEU A 1 305 ? 89.539  129.984 109.906 1.00 112.23 ? 305 LEU A O   1 
ATOM   1936 C CB  . LEU A 1 305 ? 90.742  130.269 106.954 1.00 149.57 ? 305 LEU A CB  1 
ATOM   1937 C CG  . LEU A 1 305 ? 91.027  131.617 107.610 1.00 197.25 ? 305 LEU A CG  1 
ATOM   1938 C CD1 . LEU A 1 305 ? 92.325  131.570 108.406 1.00 223.36 ? 305 LEU A CD1 1 
ATOM   1939 C CD2 . LEU A 1 305 ? 91.073  132.715 106.556 1.00 248.00 ? 305 LEU A CD2 1 
ATOM   1940 N N   . GLU A 1 306 ? 88.134  128.900 108.488 1.00 149.39 ? 306 GLU A N   1 
ATOM   1941 C CA  . GLU A 1 306 ? 86.872  129.075 109.204 1.00 150.91 ? 306 GLU A CA  1 
ATOM   1942 C C   . GLU A 1 306 ? 86.696  127.968 110.249 1.00 118.64 ? 306 GLU A C   1 
ATOM   1943 O O   . GLU A 1 306 ? 86.273  128.234 111.374 1.00 121.10 ? 306 GLU A O   1 
ATOM   1944 C CB  . GLU A 1 306 ? 85.810  129.105 108.098 1.00 175.15 ? 306 GLU A CB  1 
ATOM   1945 C CG  . GLU A 1 306 ? 84.342  129.091 108.494 1.00 225.27 ? 306 GLU A CG  1 
ATOM   1946 C CD  . GLU A 1 306 ? 83.448  128.890 107.273 1.00 267.44 ? 306 GLU A CD  1 
ATOM   1947 O OE1 . GLU A 1 306 ? 84.004  128.662 106.161 1.00 264.31 ? 306 GLU A OE1 1 
ATOM   1948 O OE2 . GLU A 1 306 ? 82.207  128.965 107.423 1.00 297.69 ? 306 GLU A OE2 1 
ATOM   1949 N N   . LEU A 1 307 ? 87.058  126.729 109.874 1.00 104.98 ? 307 LEU A N   1 
ATOM   1950 C CA  . LEU A 1 307 ? 87.078  125.573 110.770 1.00 88.44  ? 307 LEU A CA  1 
ATOM   1951 C C   . LEU A 1 307 ? 88.081  125.770 111.915 1.00 97.76  ? 307 LEU A C   1 
ATOM   1952 O O   . LEU A 1 307 ? 87.790  125.418 113.048 1.00 93.05  ? 307 LEU A O   1 
ATOM   1953 C CB  . LEU A 1 307 ? 87.437  124.338 109.941 1.00 78.80  ? 307 LEU A CB  1 
ATOM   1954 C CG  . LEU A 1 307 ? 87.364  122.993 110.648 1.00 69.10  ? 307 LEU A CG  1 
ATOM   1955 C CD1 . LEU A 1 307 ? 85.920  122.655 110.923 1.00 81.75  ? 307 LEU A CD1 1 
ATOM   1956 C CD2 . LEU A 1 307 ? 88.021  121.900 109.805 1.00 77.64  ? 307 LEU A CD2 1 
ATOM   1957 N N   . LEU A 1 308 ? 89.253  126.354 111.617 1.00 117.17 ? 308 LEU A N   1 
ATOM   1958 C CA  . LEU A 1 308 ? 90.310  126.609 112.590 1.00 104.18 ? 308 LEU A CA  1 
ATOM   1959 C C   . LEU A 1 308 ? 89.894  127.573 113.707 1.00 111.23 ? 308 LEU A C   1 
ATOM   1960 O O   . LEU A 1 308 ? 90.606  127.649 114.709 1.00 117.69 ? 308 LEU A O   1 
ATOM   1961 C CB  . LEU A 1 308 ? 91.520  127.186 111.852 1.00 107.24 ? 308 LEU A CB  1 
ATOM   1962 C CG  . LEU A 1 308 ? 92.501  126.170 111.266 1.00 125.90 ? 308 LEU A CG  1 
ATOM   1963 C CD1 . LEU A 1 308 ? 93.400  126.804 110.223 1.00 162.34 ? 308 LEU A CD1 1 
ATOM   1964 C CD2 . LEU A 1 308 ? 93.364  125.561 112.346 1.00 130.24 ? 308 LEU A CD2 1 
ATOM   1965 N N   . ARG A 1 309 ? 88.774  128.309 113.553 1.00 124.72 ? 309 ARG A N   1 
ATOM   1966 C CA  . ARG A 1 309 ? 88.462  129.419 114.447 1.00 164.49 ? 309 ARG A CA  1 
ATOM   1967 C C   . ARG A 1 309 ? 87.119  129.274 115.173 1.00 176.48 ? 309 ARG A C   1 
ATOM   1968 O O   . ARG A 1 309 ? 87.002  129.754 116.302 1.00 210.52 ? 309 ARG A O   1 
ATOM   1969 C CB  . ARG A 1 309 ? 88.554  130.741 113.678 1.00 189.45 ? 309 ARG A CB  1 
ATOM   1970 C CG  . ARG A 1 309 ? 89.988  131.232 113.538 1.00 235.80 ? 309 ARG A CG  1 
ATOM   1971 C CD  . ARG A 1 309 ? 90.138  132.487 112.687 1.00 255.37 ? 309 ARG A CD  1 
ATOM   1972 N NE  . ARG A 1 309 ? 91.353  133.252 112.977 1.00 261.20 ? 309 ARG A NE  1 
ATOM   1973 C CZ  . ARG A 1 309 ? 92.602  132.872 112.694 1.00 254.80 ? 309 ARG A CZ  1 
ATOM   1974 N NH1 . ARG A 1 309 ? 93.622  133.625 113.064 1.00 246.91 ? 309 ARG A NH1 1 
ATOM   1975 N NH2 . ARG A 1 309 ? 92.838  131.740 112.052 1.00 258.80 ? 309 ARG A NH2 1 
ATOM   1976 N N   . ALA A 1 310 ? 86.121  128.618 114.560 1.00 164.20 ? 310 ALA A N   1 
ATOM   1977 C CA  . ALA A 1 310 ? 84.793  128.480 115.149 1.00 165.26 ? 310 ALA A CA  1 
ATOM   1978 C C   . ALA A 1 310 ? 84.859  127.786 116.511 1.00 155.89 ? 310 ALA A C   1 
ATOM   1979 O O   . ALA A 1 310 ? 85.530  126.760 116.655 1.00 153.84 ? 310 ALA A O   1 
ATOM   1980 C CB  . ALA A 1 310 ? 83.895  127.729 114.194 1.00 174.30 ? 310 ALA A CB  1 
ATOM   1981 N N   . PRO A 1 311 ? 84.148  128.295 117.555 1.00 167.03 ? 311 PRO A N   1 
ATOM   1982 C CA  . PRO A 1 311 ? 84.233  127.718 118.898 1.00 155.50 ? 311 PRO A CA  1 
ATOM   1983 C C   . PRO A 1 311 ? 83.530  126.367 119.067 1.00 143.08 ? 311 PRO A C   1 
ATOM   1984 O O   . PRO A 1 311 ? 83.963  125.569 119.889 1.00 114.58 ? 311 PRO A O   1 
ATOM   1985 C CB  . PRO A 1 311 ? 83.606  128.804 119.787 1.00 153.84 ? 311 PRO A CB  1 
ATOM   1986 C CG  . PRO A 1 311 ? 82.625  129.510 118.881 1.00 163.69 ? 311 PRO A CG  1 
ATOM   1987 C CD  . PRO A 1 311 ? 83.268  129.476 117.510 1.00 173.99 ? 311 PRO A CD  1 
ATOM   1988 N N   . TYR A 1 312 ? 82.496  126.089 118.256 1.00 151.72 ? 312 TYR A N   1 
ATOM   1989 C CA  . TYR A 1 312 ? 81.690  124.883 118.408 1.00 163.39 ? 312 TYR A CA  1 
ATOM   1990 C C   . TYR A 1 312 ? 82.399  123.629 117.876 1.00 137.36 ? 312 TYR A C   1 
ATOM   1991 O O   . TYR A 1 312 ? 81.774  122.566 117.852 1.00 122.26 ? 312 TYR A O   1 
ATOM   1992 C CB  . TYR A 1 312 ? 80.314  125.110 117.763 1.00 179.44 ? 312 TYR A CB  1 
ATOM   1993 C CG  . TYR A 1 312 ? 80.304  125.250 116.246 1.00 176.12 ? 312 TYR A CG  1 
ATOM   1994 C CD1 . TYR A 1 312 ? 80.227  124.135 115.421 1.00 161.47 ? 312 TYR A CD1 1 
ATOM   1995 C CD2 . TYR A 1 312 ? 80.367  126.500 115.643 1.00 205.00 ? 312 TYR A CD2 1 
ATOM   1996 C CE1 . TYR A 1 312 ? 80.237  124.259 114.041 1.00 209.35 ? 312 TYR A CE1 1 
ATOM   1997 C CE2 . TYR A 1 312 ? 80.363  126.637 114.263 1.00 241.33 ? 312 TYR A CE2 1 
ATOM   1998 C CZ  . TYR A 1 312 ? 80.298  125.513 113.456 1.00 226.75 ? 312 TYR A CZ  1 
ATOM   1999 O OH  . TYR A 1 312 ? 80.294  125.629 112.092 1.00 192.09 ? 312 TYR A OH  1 
ATOM   2000 N N   . VAL A 1 313 ? 83.692  123.731 117.484 1.00 122.45 ? 313 VAL A N   1 
ATOM   2001 C CA  . VAL A 1 313 ? 84.515  122.575 117.128 1.00 111.88 ? 313 VAL A CA  1 
ATOM   2002 C C   . VAL A 1 313 ? 85.950  122.660 117.679 1.00 120.70 ? 313 VAL A C   1 
ATOM   2003 O O   . VAL A 1 313 ? 86.783  121.829 117.312 1.00 116.48 ? 313 VAL A O   1 
ATOM   2004 C CB  . VAL A 1 313 ? 84.591  122.344 115.610 1.00 88.70  ? 313 VAL A CB  1 
ATOM   2005 C CG1 . VAL A 1 313 ? 83.248  121.958 115.016 1.00 92.29  ? 313 VAL A CG1 1 
ATOM   2006 C CG2 . VAL A 1 313 ? 85.179  123.552 114.895 1.00 106.88 ? 313 VAL A CG2 1 
ATOM   2007 N N   . ARG A 1 314 ? 86.270  123.616 118.559 1.00 120.81 ? 314 ARG A N   1 
ATOM   2008 C CA  . ARG A 1 314 ? 87.664  123.983 118.795 1.00 113.36 ? 314 ARG A CA  1 
ATOM   2009 C C   . ARG A 1 314 ? 88.488  122.809 119.330 1.00 117.82 ? 314 ARG A C   1 
ATOM   2010 O O   . ARG A 1 314 ? 89.628  122.636 118.895 1.00 133.75 ? 314 ARG A O   1 
ATOM   2011 C CB  . ARG A 1 314 ? 87.781  125.215 119.698 1.00 110.71 ? 314 ARG A CB  1 
ATOM   2012 C CG  . ARG A 1 314 ? 89.203  125.747 119.803 1.00 131.43 ? 314 ARG A CG  1 
ATOM   2013 C CD  . ARG A 1 314 ? 89.302  127.131 120.411 1.00 159.36 ? 314 ARG A CD  1 
ATOM   2014 N NE  . ARG A 1 314 ? 88.742  128.167 119.552 1.00 182.16 ? 314 ARG A NE  1 
ATOM   2015 C CZ  . ARG A 1 314 ? 88.617  129.451 119.896 1.00 213.35 ? 314 ARG A CZ  1 
ATOM   2016 N NH1 . ARG A 1 314 ? 88.079  130.310 119.048 1.00 238.91 ? 314 ARG A NH1 1 
ATOM   2017 N NH2 . ARG A 1 314 ? 89.019  129.867 121.088 1.00 204.78 ? 314 ARG A NH2 1 
ATOM   2018 N N   . TRP A 1 315 ? 87.935  121.983 120.233 1.00 114.81 ? 315 TRP A N   1 
ATOM   2019 C CA  . TRP A 1 315 ? 88.695  120.864 120.782 1.00 102.39 ? 315 TRP A CA  1 
ATOM   2020 C C   . TRP A 1 315 ? 88.771  119.663 119.836 1.00 86.07  ? 315 TRP A C   1 
ATOM   2021 O O   . TRP A 1 315 ? 89.629  118.804 120.027 1.00 91.52  ? 315 TRP A O   1 
ATOM   2022 C CB  . TRP A 1 315 ? 88.131  120.455 122.144 1.00 114.16 ? 315 TRP A CB  1 
ATOM   2023 C CG  . TRP A 1 315 ? 88.502  121.450 123.198 1.00 97.30  ? 315 TRP A CG  1 
ATOM   2024 C CD1 . TRP A 1 315 ? 87.725  122.470 123.662 1.00 128.39 ? 315 TRP A CD1 1 
ATOM   2025 C CD2 . TRP A 1 315 ? 89.763  121.547 123.886 1.00 92.69  ? 315 TRP A CD2 1 
ATOM   2026 N NE1 . TRP A 1 315 ? 88.407  123.189 124.606 1.00 142.00 ? 315 TRP A NE1 1 
ATOM   2027 C CE2 . TRP A 1 315 ? 89.656  122.642 124.773 1.00 121.10 ? 315 TRP A CE2 1 
ATOM   2028 C CE3 . TRP A 1 315 ? 90.952  120.811 123.866 1.00 102.28 ? 315 TRP A CE3 1 
ATOM   2029 C CZ2 . TRP A 1 315 ? 90.700  123.025 125.611 1.00 143.00 ? 315 TRP A CZ2 1 
ATOM   2030 C CZ3 . TRP A 1 315 ? 91.983  121.189 124.694 1.00 133.51 ? 315 TRP A CZ3 1 
ATOM   2031 C CH2 . TRP A 1 315 ? 91.858  122.282 125.553 1.00 159.44 ? 315 TRP A CH2 1 
ATOM   2032 N N   . GLN A 1 316 ? 87.900  119.599 118.820 1.00 86.68  ? 316 GLN A N   1 
ATOM   2033 C CA  . GLN A 1 316 ? 88.015  118.580 117.786 1.00 101.68 ? 316 GLN A CA  1 
ATOM   2034 C C   . GLN A 1 316 ? 89.130  118.928 116.794 1.00 92.82  ? 316 GLN A C   1 
ATOM   2035 O O   . GLN A 1 316 ? 89.697  118.029 116.175 1.00 81.57  ? 316 GLN A O   1 
ATOM   2036 C CB  . GLN A 1 316 ? 86.653  118.388 117.111 1.00 102.97 ? 316 GLN A CB  1 
ATOM   2037 C CG  . GLN A 1 316 ? 85.633  117.740 118.023 1.00 118.84 ? 316 GLN A CG  1 
ATOM   2038 C CD  . GLN A 1 316 ? 84.280  118.386 117.951 1.00 126.23 ? 316 GLN A CD  1 
ATOM   2039 O OE1 . GLN A 1 316 ? 83.997  119.322 118.685 1.00 125.26 ? 316 GLN A OE1 1 
ATOM   2040 N NE2 . GLN A 1 316 ? 83.402  117.823 117.139 1.00 154.71 ? 316 GLN A NE2 1 
ATOM   2041 N N   . VAL A 1 317 ? 89.463  120.224 116.661 1.00 95.66  ? 317 VAL A N   1 
ATOM   2042 C CA  . VAL A 1 317 ? 90.623  120.653 115.883 1.00 88.88  ? 317 VAL A CA  1 
ATOM   2043 C C   . VAL A 1 317 ? 91.903  120.504 116.715 1.00 91.60  ? 317 VAL A C   1 
ATOM   2044 O O   . VAL A 1 317 ? 92.866  119.924 116.225 1.00 90.98  ? 317 VAL A O   1 
ATOM   2045 C CB  . VAL A 1 317 ? 90.472  122.081 115.332 1.00 79.72  ? 317 VAL A CB  1 
ATOM   2046 C CG1 . VAL A 1 317 ? 91.691  122.464 114.503 1.00 74.16  ? 317 VAL A CG1 1 
ATOM   2047 C CG2 . VAL A 1 317 ? 89.211  122.257 114.514 1.00 82.13  ? 317 VAL A CG2 1 
ATOM   2048 N N   . VAL A 1 318 ? 91.929  120.974 117.972 1.00 85.14  ? 318 VAL A N   1 
ATOM   2049 C CA  . VAL A 1 318 ? 93.118  120.813 118.811 1.00 72.04  ? 318 VAL A CA  1 
ATOM   2050 C C   . VAL A 1 318 ? 93.472  119.335 119.020 1.00 66.34  ? 318 VAL A C   1 
ATOM   2051 O O   . VAL A 1 318 ? 94.645  118.995 118.976 1.00 69.41  ? 318 VAL A O   1 
ATOM   2052 C CB  . VAL A 1 318 ? 92.981  121.533 120.169 1.00 81.53  ? 318 VAL A CB  1 
ATOM   2053 C CG1 . VAL A 1 318 ? 94.123  121.201 121.114 1.00 69.45  ? 318 VAL A CG1 1 
ATOM   2054 C CG2 . VAL A 1 318 ? 92.903  123.045 119.976 1.00 113.18 ? 318 VAL A CG2 1 
ATOM   2055 N N   . THR A 1 319 ? 92.475  118.445 119.193 1.00 69.90  ? 319 THR A N   1 
ATOM   2056 C CA  . THR A 1 319 ? 92.746  117.035 119.428 1.00 60.78  ? 319 THR A CA  1 
ATOM   2057 C C   . THR A 1 319 ? 93.167  116.312 118.155 1.00 54.54  ? 319 THR A C   1 
ATOM   2058 O O   . THR A 1 319 ? 93.717  115.214 118.266 1.00 62.66  ? 319 THR A O   1 
ATOM   2059 C CB  . THR A 1 319 ? 91.571  116.328 120.110 1.00 58.77  ? 319 THR A CB  1 
ATOM   2060 O OG1 . THR A 1 319 ? 91.287  117.031 121.311 1.00 44.16  ? 319 THR A OG1 1 
ATOM   2061 C CG2 . THR A 1 319 ? 91.865  114.890 120.461 1.00 57.77  ? 319 THR A CG2 1 
ATOM   2062 N N   . VAL A 1 320 ? 92.965  116.904 116.963 1.00 64.78  ? 320 VAL A N   1 
ATOM   2063 C CA  . VAL A 1 320 ? 93.494  116.290 115.741 1.00 80.73  ? 320 VAL A CA  1 
ATOM   2064 C C   . VAL A 1 320 ? 94.898  116.820 115.421 1.00 66.34  ? 320 VAL A C   1 
ATOM   2065 O O   . VAL A 1 320 ? 95.744  116.052 114.974 1.00 70.29  ? 320 VAL A O   1 
ATOM   2066 C CB  . VAL A 1 320 ? 92.541  116.364 114.531 1.00 87.06  ? 320 VAL A CB  1 
ATOM   2067 C CG1 . VAL A 1 320 ? 92.633  117.660 113.733 1.00 86.96  ? 320 VAL A CG1 1 
ATOM   2068 C CG2 . VAL A 1 320 ? 92.798  115.184 113.621 1.00 90.30  ? 320 VAL A CG2 1 
ATOM   2069 N N   . ILE A 1 321 ? 95.179  118.096 115.713 1.00 67.51  ? 321 ILE A N   1 
ATOM   2070 C CA  . ILE A 1 321 ? 96.528  118.633 115.584 1.00 69.51  ? 321 ILE A CA  1 
ATOM   2071 C C   . ILE A 1 321 ? 97.456  117.952 116.611 1.00 73.31  ? 321 ILE A C   1 
ATOM   2072 O O   . ILE A 1 321 ? 98.558  117.556 116.253 1.00 83.37  ? 321 ILE A O   1 
ATOM   2073 C CB  . ILE A 1 321 ? 96.513  120.170 115.710 1.00 70.28  ? 321 ILE A CB  1 
ATOM   2074 C CG1 . ILE A 1 321 ? 95.769  120.813 114.550 1.00 68.01  ? 321 ILE A CG1 1 
ATOM   2075 C CG2 . ILE A 1 321 ? 97.903  120.751 115.886 1.00 80.84  ? 321 ILE A CG2 1 
ATOM   2076 C CD1 . ILE A 1 321 ? 95.682  122.331 114.629 1.00 81.74  ? 321 ILE A CD1 1 
ATOM   2077 N N   . VAL A 1 322 ? 97.022  117.757 117.863 1.00 66.57  ? 322 VAL A N   1 
ATOM   2078 C CA  . VAL A 1 322 ? 97.866  117.173 118.891 1.00 71.06  ? 322 VAL A CA  1 
ATOM   2079 C C   . VAL A 1 322 ? 98.021  115.660 118.728 1.00 69.58  ? 322 VAL A C   1 
ATOM   2080 O O   . VAL A 1 322 ? 99.037  115.114 119.134 1.00 97.86  ? 322 VAL A O   1 
ATOM   2081 C CB  . VAL A 1 322 ? 97.375  117.548 120.309 1.00 79.24  ? 322 VAL A CB  1 
ATOM   2082 C CG1 . VAL A 1 322 ? 98.047  116.711 121.407 1.00 66.48  ? 322 VAL A CG1 1 
ATOM   2083 C CG2 . VAL A 1 322 ? 97.563  119.051 120.551 1.00 91.59  ? 322 VAL A CG2 1 
ATOM   2084 N N   . THR A 1 323 ? 97.056  114.953 118.120 1.00 74.96  ? 323 THR A N   1 
ATOM   2085 C CA  . THR A 1 323 ? 97.251  113.546 117.803 1.00 66.45  ? 323 THR A CA  1 
ATOM   2086 C C   . THR A 1 323 ? 98.216  113.413 116.628 1.00 60.80  ? 323 THR A C   1 
ATOM   2087 O O   . THR A 1 323 ? 99.103  112.571 116.668 1.00 70.10  ? 323 THR A O   1 
ATOM   2088 C CB  . THR A 1 323 ? 95.936  112.813 117.492 1.00 75.47  ? 323 THR A CB  1 
ATOM   2089 O OG1 . THR A 1 323 ? 95.079  112.884 118.637 1.00 76.60  ? 323 THR A OG1 1 
ATOM   2090 C CG2 . THR A 1 323 ? 96.134  111.360 117.103 1.00 62.38  ? 323 THR A CG2 1 
ATOM   2091 N N   . MET A 1 324 ? 98.061  114.234 115.586 1.00 70.36  ? 324 MET A N   1 
ATOM   2092 C CA  . MET A 1 324 ? 98.862  114.104 114.375 1.00 88.48  ? 324 MET A CA  1 
ATOM   2093 C C   . MET A 1 324 ? 100.321 114.546 114.589 1.00 97.94  ? 324 MET A C   1 
ATOM   2094 O O   . MET A 1 324 ? 101.223 113.962 114.001 1.00 94.46  ? 324 MET A O   1 
ATOM   2095 C CB  . MET A 1 324 ? 98.257  114.913 113.229 1.00 83.33  ? 324 MET A CB  1 
ATOM   2096 C CG  . MET A 1 324 ? 97.059  114.189 112.635 1.00 100.93 ? 324 MET A CG  1 
ATOM   2097 S SD  . MET A 1 324 ? 97.534  112.697 111.764 1.00 98.28  ? 324 MET A SD  1 
ATOM   2098 C CE  . MET A 1 324 ? 95.980  112.360 110.919 1.00 122.63 ? 324 MET A CE  1 
ATOM   2099 N N   . ALA A 1 325 ? 100.570 115.549 115.441 1.00 81.47  ? 325 ALA A N   1 
ATOM   2100 C CA  . ALA A 1 325 ? 101.928 115.923 115.768 1.00 77.59  ? 325 ALA A CA  1 
ATOM   2101 C C   . ALA A 1 325 ? 102.641 114.762 116.456 1.00 93.37  ? 325 ALA A C   1 
ATOM   2102 O O   . ALA A 1 325 ? 103.689 114.330 115.978 1.00 115.89 ? 325 ALA A O   1 
ATOM   2103 C CB  . ALA A 1 325 ? 101.924 117.185 116.606 1.00 101.62 ? 325 ALA A CB  1 
ATOM   2104 N N   . CYS A 1 326 ? 102.082 114.223 117.551 1.00 88.50  ? 326 CYS A N   1 
ATOM   2105 C CA  . CYS A 1 326 ? 102.725 113.133 118.282 1.00 79.71  ? 326 CYS A CA  1 
ATOM   2106 C C   . CYS A 1 326 ? 102.861 111.858 117.439 1.00 79.02  ? 326 CYS A C   1 
ATOM   2107 O O   . CYS A 1 326 ? 103.814 111.116 117.629 1.00 93.36  ? 326 CYS A O   1 
ATOM   2108 C CB  . CYS A 1 326 ? 101.985 112.847 119.582 1.00 84.62  ? 326 CYS A CB  1 
ATOM   2109 S SG  . CYS A 1 326 ? 101.967 114.306 120.660 1.00 116.41 ? 326 CYS A SG  1 
ATOM   2110 N N   . TYR A 1 327 ? 101.962 111.614 116.481 1.00 75.90  ? 327 TYR A N   1 
ATOM   2111 C CA  . TYR A 1 327 ? 102.052 110.466 115.591 1.00 70.16  ? 327 TYR A CA  1 
ATOM   2112 C C   . TYR A 1 327 ? 103.292 110.511 114.697 1.00 72.40  ? 327 TYR A C   1 
ATOM   2113 O O   . TYR A 1 327 ? 103.673 109.464 114.155 1.00 107.88 ? 327 TYR A O   1 
ATOM   2114 C CB  . TYR A 1 327 ? 100.772 110.423 114.765 1.00 80.01  ? 327 TYR A CB  1 
ATOM   2115 C CG  . TYR A 1 327 ? 100.671 109.380 113.661 1.00 84.05  ? 327 TYR A CG  1 
ATOM   2116 C CD1 . TYR A 1 327 ? 100.424 108.053 113.960 1.00 102.42 ? 327 TYR A CD1 1 
ATOM   2117 C CD2 . TYR A 1 327 ? 100.758 109.740 112.320 1.00 100.15 ? 327 TYR A CD2 1 
ATOM   2118 C CE1 . TYR A 1 327 ? 100.254 107.106 112.958 1.00 104.51 ? 327 TYR A CE1 1 
ATOM   2119 C CE2 . TYR A 1 327 ? 100.649 108.800 111.314 1.00 124.94 ? 327 TYR A CE2 1 
ATOM   2120 C CZ  . TYR A 1 327 ? 100.361 107.481 111.632 1.00 121.78 ? 327 TYR A CZ  1 
ATOM   2121 O OH  . TYR A 1 327 ? 100.222 106.529 110.661 1.00 149.90 ? 327 TYR A OH  1 
ATOM   2122 N N   . GLN A 1 328 ? 103.945 111.680 114.549 1.00 60.10  ? 328 GLN A N   1 
ATOM   2123 C CA  . GLN A 1 328 ? 105.196 111.794 113.802 1.00 62.67  ? 328 GLN A CA  1 
ATOM   2124 C C   . GLN A 1 328 ? 106.386 112.139 114.712 1.00 80.29  ? 328 GLN A C   1 
ATOM   2125 O O   . GLN A 1 328 ? 107.471 111.576 114.529 1.00 81.53  ? 328 GLN A O   1 
ATOM   2126 C CB  . GLN A 1 328 ? 105.066 112.839 112.697 1.00 55.74  ? 328 GLN A CB  1 
ATOM   2127 C CG  . GLN A 1 328 ? 104.160 112.407 111.543 1.00 70.05  ? 328 GLN A CG  1 
ATOM   2128 C CD  . GLN A 1 328 ? 104.737 111.292 110.719 1.00 71.91  ? 328 GLN A CD  1 
ATOM   2129 O OE1 . GLN A 1 328 ? 105.743 110.702 111.082 1.00 123.62 ? 328 GLN A OE1 1 
ATOM   2130 N NE2 . GLN A 1 328 ? 104.143 111.010 109.581 1.00 73.72  ? 328 GLN A NE2 1 
ATOM   2131 N N   . LEU A 1 329 ? 106.181 113.042 115.688 1.00 84.71  ? 329 LEU A N   1 
ATOM   2132 C CA  . LEU A 1 329 ? 107.237 113.465 116.600 1.00 70.02  ? 329 LEU A CA  1 
ATOM   2133 C C   . LEU A 1 329 ? 107.504 112.417 117.698 1.00 81.26  ? 329 LEU A C   1 
ATOM   2134 O O   . LEU A 1 329 ? 108.402 112.609 118.514 1.00 104.52 ? 329 LEU A O   1 
ATOM   2135 C CB  . LEU A 1 329 ? 106.832 114.802 117.231 1.00 63.85  ? 329 LEU A CB  1 
ATOM   2136 C CG  . LEU A 1 329 ? 106.598 115.960 116.283 1.00 70.97  ? 329 LEU A CG  1 
ATOM   2137 C CD1 . LEU A 1 329 ? 106.312 117.225 117.093 1.00 86.07  ? 329 LEU A CD1 1 
ATOM   2138 C CD2 . LEU A 1 329 ? 107.796 116.139 115.367 1.00 98.16  ? 329 LEU A CD2 1 
ATOM   2139 N N   . CYS A 1 330 ? 106.754 111.312 117.740 1.00 73.83  ? 330 CYS A N   1 
ATOM   2140 C CA  . CYS A 1 330 ? 107.172 110.139 118.495 1.00 86.24  ? 330 CYS A CA  1 
ATOM   2141 C C   . CYS A 1 330 ? 108.401 109.472 117.868 1.00 102.57 ? 330 CYS A C   1 
ATOM   2142 O O   . CYS A 1 330 ? 108.897 108.485 118.402 1.00 117.86 ? 330 CYS A O   1 
ATOM   2143 C CB  . CYS A 1 330 ? 106.053 109.102 118.558 1.00 93.72  ? 330 CYS A CB  1 
ATOM   2144 S SG  . CYS A 1 330 ? 105.532 108.524 116.919 1.00 80.99  ? 330 CYS A SG  1 
ATOM   2145 N N   . GLY A 1 331 ? 108.845 109.949 116.696 1.00 108.17 ? 331 GLY A N   1 
ATOM   2146 C CA  . GLY A 1 331 ? 110.182 109.657 116.201 1.00 105.89 ? 331 GLY A CA  1 
ATOM   2147 C C   . GLY A 1 331 ? 110.311 108.328 115.451 1.00 80.32  ? 331 GLY A C   1 
ATOM   2148 O O   . GLY A 1 331 ? 111.426 107.954 115.111 1.00 79.24  ? 331 GLY A O   1 
ATOM   2149 N N   . LEU A 1 332 ? 109.211 107.650 115.134 1.00 74.06  ? 332 LEU A N   1 
ATOM   2150 C CA  . LEU A 1 332 ? 109.316 106.374 114.454 1.00 97.89  ? 332 LEU A CA  1 
ATOM   2151 C C   . LEU A 1 332 ? 109.959 106.549 113.066 1.00 86.81  ? 332 LEU A C   1 
ATOM   2152 O O   . LEU A 1 332 ? 110.746 105.697 112.626 1.00 83.19  ? 332 LEU A O   1 
ATOM   2153 C CB  . LEU A 1 332 ? 107.960 105.662 114.349 1.00 107.42 ? 332 LEU A CB  1 
ATOM   2154 C CG  . LEU A 1 332 ? 108.062 104.227 113.811 1.00 117.53 ? 332 LEU A CG  1 
ATOM   2155 C CD1 . LEU A 1 332 ? 108.754 103.332 114.834 1.00 129.66 ? 332 LEU A CD1 1 
ATOM   2156 C CD2 . LEU A 1 332 ? 106.719 103.648 113.464 1.00 111.71 ? 332 LEU A CD2 1 
ATOM   2157 N N   . ASN A 1 333 ? 109.689 107.663 112.382 1.00 79.58  ? 333 ASN A N   1 
ATOM   2158 C CA  . ASN A 1 333 ? 110.317 107.891 111.098 1.00 79.37  ? 333 ASN A CA  1 
ATOM   2159 C C   . ASN A 1 333 ? 111.820 108.131 111.247 1.00 72.69  ? 333 ASN A C   1 
ATOM   2160 O O   . ASN A 1 333 ? 112.569 107.783 110.342 1.00 81.83  ? 333 ASN A O   1 
ATOM   2161 C CB  . ASN A 1 333 ? 109.546 108.962 110.319 1.00 93.19  ? 333 ASN A CB  1 
ATOM   2162 C CG  . ASN A 1 333 ? 108.406 108.334 109.554 1.00 83.71  ? 333 ASN A CG  1 
ATOM   2163 O OD1 . ASN A 1 333 ? 108.624 107.480 108.709 1.00 73.11  ? 333 ASN A OD1 1 
ATOM   2164 N ND2 . ASN A 1 333 ? 107.180 108.665 109.906 1.00 114.73 ? 333 ASN A ND2 1 
ATOM   2165 N N   . ALA A 1 334 ? 112.304 108.681 112.370 1.00 72.82  ? 334 ALA A N   1 
ATOM   2166 C CA  . ALA A 1 334 ? 113.741 108.771 112.605 1.00 67.04  ? 334 ALA A CA  1 
ATOM   2167 C C   . ALA A 1 334 ? 114.361 107.383 112.773 1.00 64.72  ? 334 ALA A C   1 
ATOM   2168 O O   . ALA A 1 334 ? 115.540 107.200 112.532 1.00 78.09  ? 334 ALA A O   1 
ATOM   2169 C CB  . ALA A 1 334 ? 114.033 109.678 113.784 1.00 63.74  ? 334 ALA A CB  1 
ATOM   2170 N N   . ILE A 1 335 ? 113.590 106.394 113.238 1.00 74.86  ? 335 ILE A N   1 
ATOM   2171 C CA  . ILE A 1 335 ? 114.049 105.014 113.333 1.00 71.99  ? 335 ILE A CA  1 
ATOM   2172 C C   . ILE A 1 335 ? 114.086 104.365 111.943 1.00 67.56  ? 335 ILE A C   1 
ATOM   2173 O O   . ILE A 1 335 ? 114.896 103.463 111.747 1.00 73.52  ? 335 ILE A O   1 
ATOM   2174 C CB  . ILE A 1 335 ? 113.207 104.233 114.372 1.00 75.85  ? 335 ILE A CB  1 
ATOM   2175 C CG1 . ILE A 1 335 ? 113.571 104.678 115.794 1.00 97.02  ? 335 ILE A CG1 1 
ATOM   2176 C CG2 . ILE A 1 335 ? 113.283 102.725 114.227 1.00 78.04  ? 335 ILE A CG2 1 
ATOM   2177 C CD1 . ILE A 1 335 ? 112.548 104.317 116.863 1.00 114.67 ? 335 ILE A CD1 1 
ATOM   2178 N N   . TRP A 1 336 ? 113.281 104.819 110.971 1.00 75.74  ? 336 TRP A N   1 
ATOM   2179 C CA  . TRP A 1 336 ? 113.330 104.254 109.620 1.00 71.91  ? 336 TRP A CA  1 
ATOM   2180 C C   . TRP A 1 336 ? 114.426 104.879 108.779 1.00 73.01  ? 336 TRP A C   1 
ATOM   2181 O O   . TRP A 1 336 ? 115.172 104.139 108.125 1.00 77.29  ? 336 TRP A O   1 
ATOM   2182 C CB  . TRP A 1 336 ? 111.990 104.361 108.861 1.00 60.79  ? 336 TRP A CB  1 
ATOM   2183 C CG  . TRP A 1 336 ? 110.865 103.556 109.446 1.00 68.39  ? 336 TRP A CG  1 
ATOM   2184 C CD1 . TRP A 1 336 ? 109.612 104.009 109.676 1.00 71.50  ? 336 TRP A CD1 1 
ATOM   2185 C CD2 . TRP A 1 336 ? 110.894 102.191 109.925 1.00 91.48  ? 336 TRP A CD2 1 
ATOM   2186 N NE1 . TRP A 1 336 ? 108.848 103.030 110.245 1.00 99.38  ? 336 TRP A NE1 1 
ATOM   2187 C CE2 . TRP A 1 336 ? 109.619 101.907 110.424 1.00 92.73  ? 336 TRP A CE2 1 
ATOM   2188 C CE3 . TRP A 1 336 ? 111.863 101.176 109.990 1.00 130.11 ? 336 TRP A CE3 1 
ATOM   2189 C CZ2 . TRP A 1 336 ? 109.309 100.671 110.987 1.00 96.43  ? 336 TRP A CZ2 1 
ATOM   2190 C CZ3 . TRP A 1 336 ? 111.537 99.962  110.519 1.00 109.03 ? 336 TRP A CZ3 1 
ATOM   2191 C CH2 . TRP A 1 336 ? 110.281 99.714  111.025 1.00 92.91  ? 336 TRP A CH2 1 
ATOM   2192 N N   . PHE A 1 337 ? 114.498 106.221 108.743 1.00 79.13  ? 337 PHE A N   1 
ATOM   2193 C CA  . PHE A 1 337 ? 115.467 106.914 107.902 1.00 66.47  ? 337 PHE A CA  1 
ATOM   2194 C C   . PHE A 1 337 ? 116.895 106.594 108.348 1.00 52.53  ? 337 PHE A C   1 
ATOM   2195 O O   . PHE A 1 337 ? 117.768 106.422 107.490 1.00 76.67  ? 337 PHE A O   1 
ATOM   2196 C CB  . PHE A 1 337 ? 115.268 108.424 107.926 1.00 59.92  ? 337 PHE A CB  1 
ATOM   2197 C CG  . PHE A 1 337 ? 113.954 108.978 107.438 1.00 73.78  ? 337 PHE A CG  1 
ATOM   2198 C CD1 . PHE A 1 337 ? 113.454 108.643 106.195 1.00 77.52  ? 337 PHE A CD1 1 
ATOM   2199 C CD2 . PHE A 1 337 ? 113.272 109.936 108.196 1.00 92.15  ? 337 PHE A CD2 1 
ATOM   2200 C CE1 . PHE A 1 337 ? 112.273 109.225 105.743 1.00 103.17 ? 337 PHE A CE1 1 
ATOM   2201 C CE2 . PHE A 1 337 ? 112.109 110.525 107.735 1.00 97.06  ? 337 PHE A CE2 1 
ATOM   2202 C CZ  . PHE A 1 337 ? 111.591 110.140 106.522 1.00 114.51 ? 337 PHE A CZ  1 
ATOM   2203 N N   . TYR A 1 338 ? 117.142 106.537 109.666 1.00 44.49  ? 338 TYR A N   1 
ATOM   2204 C CA  . TYR A 1 338 ? 118.496 106.575 110.206 1.00 49.96  ? 338 TYR A CA  1 
ATOM   2205 C C   . TYR A 1 338 ? 118.872 105.348 111.043 1.00 49.98  ? 338 TYR A C   1 
ATOM   2206 O O   . TYR A 1 338 ? 119.706 105.451 111.927 1.00 56.63  ? 338 TYR A O   1 
ATOM   2207 C CB  . TYR A 1 338 ? 118.635 107.835 111.081 1.00 56.50  ? 338 TYR A CB  1 
ATOM   2208 C CG  . TYR A 1 338 ? 118.436 109.185 110.386 1.00 62.04  ? 338 TYR A CG  1 
ATOM   2209 C CD1 . TYR A 1 338 ? 119.372 109.663 109.475 1.00 68.99  ? 338 TYR A CD1 1 
ATOM   2210 C CD2 . TYR A 1 338 ? 117.332 109.981 110.648 1.00 57.37  ? 338 TYR A CD2 1 
ATOM   2211 C CE1 . TYR A 1 338 ? 119.217 110.876 108.822 1.00 84.20  ? 338 TYR A CE1 1 
ATOM   2212 C CE2 . TYR A 1 338 ? 117.178 111.203 110.025 1.00 76.78  ? 338 TYR A CE2 1 
ATOM   2213 C CZ  . TYR A 1 338 ? 118.115 111.664 109.111 1.00 82.46  ? 338 TYR A CZ  1 
ATOM   2214 O OH  . TYR A 1 338 ? 117.963 112.883 108.498 1.00 60.30  ? 338 TYR A OH  1 
ATOM   2215 N N   . THR A 1 339 ? 118.348 104.156 110.732 1.00 59.48  ? 339 THR A N   1 
ATOM   2216 C CA  . THR A 1 339 ? 118.490 103.003 111.621 1.00 59.32  ? 339 THR A CA  1 
ATOM   2217 C C   . THR A 1 339 ? 119.946 102.582 111.807 1.00 58.66  ? 339 THR A C   1 
ATOM   2218 O O   . THR A 1 339 ? 120.334 102.206 112.902 1.00 72.91  ? 339 THR A O   1 
ATOM   2219 C CB  . THR A 1 339 ? 117.710 101.760 111.171 1.00 65.19  ? 339 THR A CB  1 
ATOM   2220 O OG1 . THR A 1 339 ? 116.615 102.085 110.323 1.00 87.33  ? 339 THR A OG1 1 
ATOM   2221 C CG2 . THR A 1 339 ? 117.163 100.991 112.354 1.00 74.19  ? 339 THR A CG2 1 
ATOM   2222 N N   . ASN A 1 340 ? 120.760 102.626 110.757 1.00 66.62  ? 340 ASN A N   1 
ATOM   2223 C CA  . ASN A 1 340 ? 122.156 102.206 110.839 1.00 69.20  ? 340 ASN A CA  1 
ATOM   2224 C C   . ASN A 1 340 ? 122.964 103.125 111.765 1.00 72.96  ? 340 ASN A C   1 
ATOM   2225 O O   . ASN A 1 340 ? 123.911 102.668 112.401 1.00 66.71  ? 340 ASN A O   1 
ATOM   2226 C CB  . ASN A 1 340 ? 122.848 102.197 109.467 1.00 97.24  ? 340 ASN A CB  1 
ATOM   2227 C CG  . ASN A 1 340 ? 122.483 101.018 108.600 1.00 94.89  ? 340 ASN A CG  1 
ATOM   2228 O OD1 . ASN A 1 340 ? 121.444 100.425 108.781 1.00 55.72  ? 340 ASN A OD1 1 
ATOM   2229 N ND2 . ASN A 1 340 ? 123.319 100.731 107.610 1.00 127.85 ? 340 ASN A ND2 1 
ATOM   2230 N N   . SER A 1 341 ? 122.626 104.428 111.824 1.00 91.15  ? 341 SER A N   1 
ATOM   2231 C CA  . SER A 1 341 ? 123.271 105.349 112.742 1.00 92.61  ? 341 SER A CA  1 
ATOM   2232 C C   . SER A 1 341 ? 122.924 105.002 114.189 1.00 82.18  ? 341 SER A C   1 
ATOM   2233 O O   . SER A 1 341 ? 123.811 104.932 115.046 1.00 108.44 ? 341 SER A O   1 
ATOM   2234 C CB  . SER A 1 341 ? 122.917 106.768 112.415 1.00 105.25 ? 341 SER A CB  1 
ATOM   2235 O OG  . SER A 1 341 ? 123.517 107.674 113.347 1.00 139.81 ? 341 SER A OG  1 
ATOM   2236 N N   . ILE A 1 342 ? 121.634 104.744 114.444 1.00 81.61  ? 342 ILE A N   1 
ATOM   2237 C CA  . ILE A 1 342 ? 121.127 104.420 115.774 1.00 93.89  ? 342 ILE A CA  1 
ATOM   2238 C C   . ILE A 1 342 ? 121.792 103.145 116.307 1.00 83.69  ? 342 ILE A C   1 
ATOM   2239 O O   . ILE A 1 342 ? 122.356 103.182 117.405 1.00 82.66  ? 342 ILE A O   1 
ATOM   2240 C CB  . ILE A 1 342 ? 119.586 104.344 115.778 1.00 76.98  ? 342 ILE A CB  1 
ATOM   2241 C CG1 . ILE A 1 342 ? 118.969 105.710 115.493 1.00 79.27  ? 342 ILE A CG1 1 
ATOM   2242 C CG2 . ILE A 1 342 ? 119.069 103.765 117.080 1.00 70.00  ? 342 ILE A CG2 1 
ATOM   2243 C CD1 . ILE A 1 342 ? 117.513 105.655 115.074 1.00 85.44  ? 342 ILE A CD1 1 
ATOM   2244 N N   . PHE A 1 343 ? 121.764 102.043 115.544 1.00 61.42  ? 343 PHE A N   1 
ATOM   2245 C CA  . PHE A 1 343 ? 122.383 100.809 115.993 1.00 73.40  ? 343 PHE A CA  1 
ATOM   2246 C C   . PHE A 1 343 ? 123.909 100.951 116.062 1.00 100.55 ? 343 PHE A C   1 
ATOM   2247 O O   . PHE A 1 343 ? 124.536 100.321 116.914 1.00 146.21 ? 343 PHE A O   1 
ATOM   2248 C CB  . PHE A 1 343 ? 121.964 99.611  115.146 1.00 63.02  ? 343 PHE A CB  1 
ATOM   2249 C CG  . PHE A 1 343 ? 120.545 99.156  115.373 1.00 80.53  ? 343 PHE A CG  1 
ATOM   2250 C CD1 . PHE A 1 343 ? 120.088 98.847  116.647 1.00 113.67 ? 343 PHE A CD1 1 
ATOM   2251 C CD2 . PHE A 1 343 ? 119.662 99.005  114.316 1.00 85.37  ? 343 PHE A CD2 1 
ATOM   2252 C CE1 . PHE A 1 343 ? 118.776 98.435  116.852 1.00 107.01 ? 343 PHE A CE1 1 
ATOM   2253 C CE2 . PHE A 1 343 ? 118.358 98.591  114.528 1.00 93.21  ? 343 PHE A CE2 1 
ATOM   2254 C CZ  . PHE A 1 343 ? 117.912 98.297  115.797 1.00 94.73  ? 343 PHE A CZ  1 
ATOM   2255 N N   . GLY A 1 344 ? 124.514 101.792 115.221 1.00 83.03  ? 344 GLY A N   1 
ATOM   2256 C CA  . GLY A 1 344 ? 125.949 102.008 115.252 1.00 82.08  ? 344 GLY A CA  1 
ATOM   2257 C C   . GLY A 1 344 ? 126.431 102.573 116.579 1.00 87.58  ? 344 GLY A C   1 
ATOM   2258 O O   . GLY A 1 344 ? 127.454 102.117 117.108 1.00 97.44  ? 344 GLY A O   1 
ATOM   2259 N N   . LYS A 1 345 ? 125.724 103.590 117.099 1.00 94.28  ? 345 LYS A N   1 
ATOM   2260 C CA  . LYS A 1 345 ? 126.099 104.255 118.340 1.00 109.66 ? 345 LYS A CA  1 
ATOM   2261 C C   . LYS A 1 345 ? 125.690 103.449 119.579 1.00 118.66 ? 345 LYS A C   1 
ATOM   2262 O O   . LYS A 1 345 ? 126.176 103.739 120.675 1.00 109.60 ? 345 LYS A O   1 
ATOM   2263 C CB  . LYS A 1 345 ? 125.495 105.657 118.375 1.00 125.20 ? 345 LYS A CB  1 
ATOM   2264 C CG  . LYS A 1 345 ? 126.211 106.689 117.520 1.00 141.19 ? 345 LYS A CG  1 
ATOM   2265 C CD  . LYS A 1 345 ? 125.829 108.103 117.913 1.00 188.98 ? 345 LYS A CD  1 
ATOM   2266 C CE  . LYS A 1 345 ? 126.815 109.150 117.443 1.00 224.32 ? 345 LYS A CE  1 
ATOM   2267 N NZ  . LYS A 1 345 ? 126.692 110.413 118.206 1.00 221.80 ? 345 LYS A NZ  1 
ATOM   2268 N N   . ALA A 1 346 ? 124.803 102.448 119.418 1.00 98.48  ? 346 ALA A N   1 
ATOM   2269 C CA  . ALA A 1 346 ? 124.397 101.565 120.502 1.00 92.38  ? 346 ALA A CA  1 
ATOM   2270 C C   . ALA A 1 346 ? 125.486 100.555 120.873 1.00 102.54 ? 346 ALA A C   1 
ATOM   2271 O O   . ALA A 1 346 ? 125.406 99.937  121.933 1.00 125.66 ? 346 ALA A O   1 
ATOM   2272 C CB  . ALA A 1 346 ? 123.112 100.871 120.118 1.00 85.43  ? 346 ALA A CB  1 
ATOM   2273 N N   . GLY A 1 347 ? 126.468 100.338 119.999 1.00 104.89 ? 347 GLY A N   1 
ATOM   2274 C CA  . GLY A 1 347 ? 127.581 99.444  120.286 1.00 119.66 ? 347 GLY A CA  1 
ATOM   2275 C C   . GLY A 1 347 ? 127.436 98.059  119.646 1.00 126.79 ? 347 GLY A C   1 
ATOM   2276 O O   . GLY A 1 347 ? 128.183 97.145  120.003 1.00 132.74 ? 347 GLY A O   1 
ATOM   2277 N N   . ILE A 1 348 ? 126.492 97.908  118.703 1.00 111.50 ? 348 ILE A N   1 
ATOM   2278 C CA  . ILE A 1 348 ? 126.345 96.685  117.919 1.00 96.69  ? 348 ILE A CA  1 
ATOM   2279 C C   . ILE A 1 348 ? 127.591 96.551  117.041 1.00 99.34  ? 348 ILE A C   1 
ATOM   2280 O O   . ILE A 1 348 ? 128.048 97.555  116.490 1.00 113.75 ? 348 ILE A O   1 
ATOM   2281 C CB  . ILE A 1 348 ? 125.048 96.718  117.070 1.00 102.14 ? 348 ILE A CB  1 
ATOM   2282 C CG1 . ILE A 1 348 ? 123.793 97.063  117.872 1.00 101.59 ? 348 ILE A CG1 1 
ATOM   2283 C CG2 . ILE A 1 348 ? 124.853 95.414  116.323 1.00 99.77  ? 348 ILE A CG2 1 
ATOM   2284 C CD1 . ILE A 1 348 ? 123.518 96.122  118.994 1.00 121.10 ? 348 ILE A CD1 1 
ATOM   2285 N N   . PRO A 1 349 ? 128.191 95.346  116.856 1.00 116.07 ? 349 PRO A N   1 
ATOM   2286 C CA  . PRO A 1 349 ? 129.370 95.194  115.994 1.00 143.13 ? 349 PRO A CA  1 
ATOM   2287 C C   . PRO A 1 349 ? 129.176 95.714  114.564 1.00 134.58 ? 349 PRO A C   1 
ATOM   2288 O O   . PRO A 1 349 ? 128.208 95.348  113.902 1.00 120.08 ? 349 PRO A O   1 
ATOM   2289 C CB  . PRO A 1 349 ? 129.620 93.677  115.986 1.00 146.55 ? 349 PRO A CB  1 
ATOM   2290 C CG  . PRO A 1 349 ? 129.036 93.211  117.300 1.00 154.25 ? 349 PRO A CG  1 
ATOM   2291 C CD  . PRO A 1 349 ? 127.816 94.084  117.505 1.00 122.07 ? 349 PRO A CD  1 
ATOM   2292 N N   . PRO A 1 350 ? 130.098 96.559  114.040 1.00 139.09 ? 350 PRO A N   1 
ATOM   2293 C CA  . PRO A 1 350 ? 129.923 97.209  112.738 1.00 128.59 ? 350 PRO A CA  1 
ATOM   2294 C C   . PRO A 1 350 ? 129.556 96.310  111.559 1.00 119.11 ? 350 PRO A C   1 
ATOM   2295 O O   . PRO A 1 350 ? 128.879 96.748  110.636 1.00 124.51 ? 350 PRO A O   1 
ATOM   2296 C CB  . PRO A 1 350 ? 131.296 97.865  112.486 1.00 177.37 ? 350 PRO A CB  1 
ATOM   2297 C CG  . PRO A 1 350 ? 131.837 98.139  113.870 1.00 193.09 ? 350 PRO A CG  1 
ATOM   2298 C CD  . PRO A 1 350 ? 131.341 96.984  114.714 1.00 176.98 ? 350 PRO A CD  1 
ATOM   2299 N N   . ALA A 1 351 ? 130.026 95.054  111.571 1.00 128.57 ? 351 ALA A N   1 
ATOM   2300 C CA  . ALA A 1 351 ? 129.814 94.115  110.480 1.00 128.27 ? 351 ALA A CA  1 
ATOM   2301 C C   . ALA A 1 351 ? 128.391 93.549  110.470 1.00 116.02 ? 351 ALA A C   1 
ATOM   2302 O O   . ALA A 1 351 ? 127.984 92.989  109.460 1.00 117.15 ? 351 ALA A O   1 
ATOM   2303 C CB  . ALA A 1 351 ? 130.842 93.010  110.598 1.00 148.36 ? 351 ALA A CB  1 
ATOM   2304 N N   . LYS A 1 352 ? 127.641 93.689  111.580 1.00 119.96 ? 352 LYS A N   1 
ATOM   2305 C CA  . LYS A 1 352 ? 126.360 93.010  111.764 1.00 105.53 ? 352 LYS A CA  1 
ATOM   2306 C C   . LYS A 1 352 ? 125.166 93.948  111.584 1.00 92.76  ? 352 LYS A C   1 
ATOM   2307 O O   . LYS A 1 352 ? 124.052 93.474  111.421 1.00 94.63  ? 352 LYS A O   1 
ATOM   2308 C CB  . LYS A 1 352 ? 126.291 92.352  113.145 1.00 104.45 ? 352 LYS A CB  1 
ATOM   2309 C CG  . LYS A 1 352 ? 127.248 91.177  113.307 1.00 138.07 ? 352 LYS A CG  1 
ATOM   2310 C CD  . LYS A 1 352 ? 127.215 90.523  114.666 1.00 162.38 ? 352 LYS A CD  1 
ATOM   2311 C CE  . LYS A 1 352 ? 128.328 89.504  114.826 1.00 187.95 ? 352 LYS A CE  1 
ATOM   2312 N NZ  . LYS A 1 352 ? 128.392 88.957  116.203 1.00 202.18 ? 352 LYS A NZ  1 
ATOM   2313 N N   . ILE A 1 353 ? 125.386 95.262  111.519 1.00 84.77  ? 353 ILE A N   1 
ATOM   2314 C CA  . ILE A 1 353 ? 124.304 96.245  111.566 1.00 80.03  ? 353 ILE A CA  1 
ATOM   2315 C C   . ILE A 1 353 ? 123.333 96.130  110.382 1.00 84.77  ? 353 ILE A C   1 
ATOM   2316 O O   . ILE A 1 353 ? 122.139 96.338  110.581 1.00 102.18 ? 353 ILE A O   1 
ATOM   2317 C CB  . ILE A 1 353 ? 124.845 97.681  111.715 1.00 70.03  ? 353 ILE A CB  1 
ATOM   2318 C CG1 . ILE A 1 353 ? 125.526 97.887  113.067 1.00 84.43  ? 353 ILE A CG1 1 
ATOM   2319 C CG2 . ILE A 1 353 ? 123.723 98.676  111.530 1.00 66.92  ? 353 ILE A CG2 1 
ATOM   2320 C CD1 . ILE A 1 353 ? 126.409 99.105  113.103 1.00 99.78  ? 353 ILE A CD1 1 
ATOM   2321 N N   . PRO A 1 354 ? 123.755 95.765  109.141 1.00 77.27  ? 354 PRO A N   1 
ATOM   2322 C CA  . PRO A 1 354 ? 122.808 95.579  108.047 1.00 78.76  ? 354 PRO A CA  1 
ATOM   2323 C C   . PRO A 1 354 ? 121.778 94.485  108.292 1.00 91.16  ? 354 PRO A C   1 
ATOM   2324 O O   . PRO A 1 354 ? 120.632 94.608  107.861 1.00 94.68  ? 354 PRO A O   1 
ATOM   2325 C CB  . PRO A 1 354 ? 123.690 95.224  106.843 1.00 94.56  ? 354 PRO A CB  1 
ATOM   2326 C CG  . PRO A 1 354 ? 125.022 95.862  107.171 1.00 112.31 ? 354 PRO A CG  1 
ATOM   2327 C CD  . PRO A 1 354 ? 125.140 95.699  108.670 1.00 88.41  ? 354 PRO A CD  1 
ATOM   2328 N N   . TYR A 1 355 ? 122.196 93.399  108.984 1.00 98.38  ? 355 TYR A N   1 
ATOM   2329 C CA  . TYR A 1 355 ? 121.369 92.221  109.235 1.00 87.21  ? 355 TYR A CA  1 
ATOM   2330 C C   . TYR A 1 355 ? 120.480 92.467  110.441 1.00 69.00  ? 355 TYR A C   1 
ATOM   2331 O O   . TYR A 1 355 ? 119.350 92.014  110.455 1.00 73.12  ? 355 TYR A O   1 
ATOM   2332 C CB  . TYR A 1 355 ? 122.267 90.988  109.395 1.00 91.11  ? 355 TYR A CB  1 
ATOM   2333 C CG  . TYR A 1 355 ? 123.242 90.870  108.241 1.00 96.90  ? 355 TYR A CG  1 
ATOM   2334 C CD1 . TYR A 1 355 ? 122.835 90.332  107.016 1.00 102.93 ? 355 TYR A CD1 1 
ATOM   2335 C CD2 . TYR A 1 355 ? 124.530 91.408  108.345 1.00 102.23 ? 355 TYR A CD2 1 
ATOM   2336 C CE1 . TYR A 1 355 ? 123.712 90.280  105.938 1.00 148.91 ? 355 TYR A CE1 1 
ATOM   2337 C CE2 . TYR A 1 355 ? 125.400 91.392  107.264 1.00 148.50 ? 355 TYR A CE2 1 
ATOM   2338 C CZ  . TYR A 1 355 ? 124.994 90.815  106.066 1.00 178.25 ? 355 TYR A CZ  1 
ATOM   2339 O OH  . TYR A 1 355 ? 125.883 90.771  105.024 1.00 160.08 ? 355 TYR A OH  1 
ATOM   2340 N N   . VAL A 1 356 ? 120.990 93.152  111.475 1.00 65.20  ? 356 VAL A N   1 
ATOM   2341 C CA  . VAL A 1 356 ? 120.209 93.524  112.663 1.00 65.86  ? 356 VAL A CA  1 
ATOM   2342 C C   . VAL A 1 356 ? 119.123 94.519  112.284 1.00 52.69  ? 356 VAL A C   1 
ATOM   2343 O O   . VAL A 1 356 ? 118.006 94.419  112.760 1.00 52.04  ? 356 VAL A O   1 
ATOM   2344 C CB  . VAL A 1 356 ? 121.106 94.056  113.792 1.00 68.37  ? 356 VAL A CB  1 
ATOM   2345 C CG1 . VAL A 1 356 ? 120.329 94.744  114.893 1.00 58.91  ? 356 VAL A CG1 1 
ATOM   2346 C CG2 . VAL A 1 356 ? 121.962 92.929  114.375 1.00 91.58  ? 356 VAL A CG2 1 
ATOM   2347 N N   . THR A 1 357 ? 119.424 95.458  111.389 1.00 56.32  ? 357 THR A N   1 
ATOM   2348 C CA  . THR A 1 357 ? 118.438 96.424  110.901 1.00 56.64  ? 357 THR A CA  1 
ATOM   2349 C C   . THR A 1 357 ? 117.242 95.725  110.255 1.00 66.30  ? 357 THR A C   1 
ATOM   2350 O O   . THR A 1 357 ? 116.125 96.156  110.462 1.00 65.25  ? 357 THR A O   1 
ATOM   2351 C CB  . THR A 1 357 ? 119.054 97.365  109.869 1.00 57.04  ? 357 THR A CB  1 
ATOM   2352 O OG1 . THR A 1 357 ? 120.036 98.142  110.555 1.00 83.43  ? 357 THR A OG1 1 
ATOM   2353 C CG2 . THR A 1 357 ? 118.077 98.263  109.165 1.00 52.34  ? 357 THR A CG2 1 
ATOM   2354 N N   . LEU A 1 358 ? 117.459 94.661  109.475 1.00 80.92  ? 358 LEU A N   1 
ATOM   2355 C CA  . LEU A 1 358 ? 116.410 94.011  108.702 1.00 78.61  ? 358 LEU A CA  1 
ATOM   2356 C C   . LEU A 1 358 ? 115.312 93.435  109.592 1.00 71.54  ? 358 LEU A C   1 
ATOM   2357 O O   . LEU A 1 358 ? 114.189 93.235  109.141 1.00 73.86  ? 358 LEU A O   1 
ATOM   2358 C CB  . LEU A 1 358 ? 117.043 92.926  107.818 1.00 71.54  ? 358 LEU A CB  1 
ATOM   2359 C CG  . LEU A 1 358 ? 116.084 92.182  106.904 1.00 76.35  ? 358 LEU A CG  1 
ATOM   2360 C CD1 . LEU A 1 358 ? 115.342 93.132  105.977 1.00 73.92  ? 358 LEU A CD1 1 
ATOM   2361 C CD2 . LEU A 1 358 ? 116.838 91.147  106.094 1.00 92.86  ? 358 LEU A CD2 1 
ATOM   2362 N N   . SER A 1 359 ? 115.621 93.169  110.865 1.00 74.95  ? 359 SER A N   1 
ATOM   2363 C CA  . SER A 1 359 ? 114.628 92.693  111.821 1.00 67.88  ? 359 SER A CA  1 
ATOM   2364 C C   . SER A 1 359 ? 113.531 93.734  112.024 1.00 60.19  ? 359 SER A C   1 
ATOM   2365 O O   . SER A 1 359 ? 112.378 93.358  112.205 1.00 69.28  ? 359 SER A O   1 
ATOM   2366 C CB  . SER A 1 359 ? 115.263 92.296  113.131 1.00 72.48  ? 359 SER A CB  1 
ATOM   2367 O OG  . SER A 1 359 ? 115.719 93.430  113.844 1.00 61.14  ? 359 SER A OG  1 
ATOM   2368 N N   . THR A 1 360 ? 113.860 95.030  111.956 1.00 61.75  ? 360 THR A N   1 
ATOM   2369 C CA  . THR A 1 360 ? 112.908 96.090  112.267 1.00 66.76  ? 360 THR A CA  1 
ATOM   2370 C C   . THR A 1 360 ? 111.741 96.081  111.285 1.00 58.18  ? 360 THR A C   1 
ATOM   2371 O O   . THR A 1 360 ? 110.598 96.077  111.730 1.00 83.66  ? 360 THR A O   1 
ATOM   2372 C CB  . THR A 1 360 ? 113.577 97.465  112.417 1.00 73.26  ? 360 THR A CB  1 
ATOM   2373 O OG1 . THR A 1 360 ? 114.179 97.851  111.178 1.00 89.31  ? 360 THR A OG1 1 
ATOM   2374 C CG2 . THR A 1 360 ? 114.615 97.501  113.515 1.00 67.72  ? 360 THR A CG2 1 
ATOM   2375 N N   . GLY A 1 361 ? 111.982 96.055  109.978 1.00 64.08  ? 361 GLY A N   1 
ATOM   2376 C CA  . GLY A 1 361 ? 110.910 95.966  108.987 1.00 77.32  ? 361 GLY A CA  1 
ATOM   2377 C C   . GLY A 1 361 ? 110.095 94.672  109.069 1.00 79.20  ? 361 GLY A C   1 
ATOM   2378 O O   . GLY A 1 361 ? 108.933 94.648  108.649 1.00 76.37  ? 361 GLY A O   1 
ATOM   2379 N N   . GLY A 1 362 ? 110.708 93.606  109.617 1.00 83.31  ? 362 GLY A N   1 
ATOM   2380 C CA  . GLY A 1 362 ? 110.033 92.346  109.892 1.00 90.41  ? 362 GLY A CA  1 
ATOM   2381 C C   . GLY A 1 362 ? 109.001 92.474  111.011 1.00 75.09  ? 362 GLY A C   1 
ATOM   2382 O O   . GLY A 1 362 ? 107.836 92.117  110.827 1.00 67.70  ? 362 GLY A O   1 
ATOM   2383 N N   . ILE A 1 363 ? 109.442 92.975  112.173 1.00 59.17  ? 363 ILE A N   1 
ATOM   2384 C CA  . ILE A 1 363 ? 108.592 93.159  113.338 1.00 61.07  ? 363 ILE A CA  1 
ATOM   2385 C C   . ILE A 1 363 ? 107.548 94.246  113.086 1.00 73.00  ? 363 ILE A C   1 
ATOM   2386 O O   . ILE A 1 363 ? 106.443 94.165  113.634 1.00 130.30 ? 363 ILE A O   1 
ATOM   2387 C CB  . ILE A 1 363 ? 109.448 93.367  114.598 1.00 69.93  ? 363 ILE A CB  1 
ATOM   2388 C CG1 . ILE A 1 363 ? 109.768 92.025  115.269 1.00 103.03 ? 363 ILE A CG1 1 
ATOM   2389 C CG2 . ILE A 1 363 ? 108.802 94.297  115.593 1.00 81.99  ? 363 ILE A CG2 1 
ATOM   2390 C CD1 . ILE A 1 363 ? 110.468 90.998  114.371 1.00 105.95 ? 363 ILE A CD1 1 
ATOM   2391 N N   . GLU A 1 364 ? 107.853 95.225  112.235 1.00 71.17  ? 364 GLU A N   1 
ATOM   2392 C CA  . GLU A 1 364 ? 106.871 96.163  111.694 1.00 80.29  ? 364 GLU A CA  1 
ATOM   2393 C C   . GLU A 1 364 ? 105.769 95.431  110.926 1.00 82.32  ? 364 GLU A C   1 
ATOM   2394 O O   . GLU A 1 364 ? 104.585 95.649  111.193 1.00 86.68  ? 364 GLU A O   1 
ATOM   2395 C CB  . GLU A 1 364 ? 107.616 97.181  110.827 1.00 99.96  ? 364 GLU A CB  1 
ATOM   2396 C CG  . GLU A 1 364 ? 106.778 98.023  109.890 1.00 117.23 ? 364 GLU A CG  1 
ATOM   2397 C CD  . GLU A 1 364 ? 106.061 99.192  110.530 1.00 116.52 ? 364 GLU A CD  1 
ATOM   2398 O OE1 . GLU A 1 364 ? 106.060 99.265  111.771 1.00 110.53 ? 364 GLU A OE1 1 
ATOM   2399 O OE2 . GLU A 1 364 ? 105.511 100.044 109.779 1.00 122.87 ? 364 GLU A OE2 1 
ATOM   2400 N N   . THR A 1 365 ? 106.144 94.557  109.978 1.00 80.16  ? 365 THR A N   1 
ATOM   2401 C CA  . THR A 1 365 ? 105.163 93.891  109.122 1.00 71.81  ? 365 THR A CA  1 
ATOM   2402 C C   . THR A 1 365 ? 104.318 92.886  109.905 1.00 74.96  ? 365 THR A C   1 
ATOM   2403 O O   . THR A 1 365 ? 103.113 92.837  109.697 1.00 98.16  ? 365 THR A O   1 
ATOM   2404 C CB  . THR A 1 365 ? 105.806 93.225  107.909 1.00 87.71  ? 365 THR A CB  1 
ATOM   2405 O OG1 . THR A 1 365 ? 106.492 94.226  107.171 1.00 99.47  ? 365 THR A OG1 1 
ATOM   2406 C CG2 . THR A 1 365 ? 104.814 92.528  107.010 1.00 96.16  ? 365 THR A CG2 1 
ATOM   2407 N N   . LEU A 1 366 ? 104.913 92.129  110.835 1.00 72.15  ? 366 LEU A N   1 
ATOM   2408 C CA  . LEU A 1 366 ? 104.133 91.252  111.703 1.00 84.16  ? 366 LEU A CA  1 
ATOM   2409 C C   . LEU A 1 366 ? 103.201 92.065  112.610 1.00 79.09  ? 366 LEU A C   1 
ATOM   2410 O O   . LEU A 1 366 ? 102.092 91.621  112.882 1.00 110.70 ? 366 LEU A O   1 
ATOM   2411 C CB  . LEU A 1 366 ? 105.059 90.367  112.542 1.00 99.63  ? 366 LEU A CB  1 
ATOM   2412 C CG  . LEU A 1 366 ? 105.716 89.227  111.775 1.00 132.03 ? 366 LEU A CG  1 
ATOM   2413 C CD1 . LEU A 1 366 ? 106.698 88.475  112.672 1.00 170.36 ? 366 LEU A CD1 1 
ATOM   2414 C CD2 . LEU A 1 366 ? 104.642 88.280  111.248 1.00 139.04 ? 366 LEU A CD2 1 
ATOM   2415 N N   . ALA A 1 367 ? 103.616 93.246  113.068 1.00 69.98  ? 367 ALA A N   1 
ATOM   2416 C CA  . ALA A 1 367 ? 102.748 94.068  113.887 1.00 84.70  ? 367 ALA A CA  1 
ATOM   2417 C C   . ALA A 1 367 ? 101.554 94.569  113.077 1.00 79.59  ? 367 ALA A C   1 
ATOM   2418 O O   . ALA A 1 367 ? 100.419 94.486  113.540 1.00 103.11 ? 367 ALA A O   1 
ATOM   2419 C CB  . ALA A 1 367 ? 103.532 95.198  114.522 1.00 102.21 ? 367 ALA A CB  1 
ATOM   2420 N N   . ALA A 1 368 ? 101.779 95.050  111.852 1.00 82.49  ? 368 ALA A N   1 
ATOM   2421 C CA  . ALA A 1 368 ? 100.705 95.565  111.012 1.00 103.89 ? 368 ALA A CA  1 
ATOM   2422 C C   . ALA A 1 368 ? 99.702  94.473  110.613 1.00 107.92 ? 368 ALA A C   1 
ATOM   2423 O O   . ALA A 1 368 ? 98.499  94.741  110.572 1.00 114.68 ? 368 ALA A O   1 
ATOM   2424 C CB  . ALA A 1 368 ? 101.301 96.252  109.801 1.00 126.59 ? 368 ALA A CB  1 
ATOM   2425 N N   . VAL A 1 369 ? 100.172 93.248  110.324 1.00 100.22 ? 369 VAL A N   1 
ATOM   2426 C CA  . VAL A 1 369 ? 99.314  92.128  109.953 1.00 97.27  ? 369 VAL A CA  1 
ATOM   2427 C C   . VAL A 1 369 ? 98.380  91.730  111.102 1.00 101.02 ? 369 VAL A C   1 
ATOM   2428 O O   . VAL A 1 369 ? 97.247  91.317  110.847 1.00 138.41 ? 369 VAL A O   1 
ATOM   2429 C CB  . VAL A 1 369 ? 100.151 90.939  109.441 1.00 108.89 ? 369 VAL A CB  1 
ATOM   2430 C CG1 . VAL A 1 369 ? 99.374  89.626  109.397 1.00 111.44 ? 369 VAL A CG1 1 
ATOM   2431 C CG2 . VAL A 1 369 ? 100.746 91.244  108.074 1.00 127.81 ? 369 VAL A CG2 1 
ATOM   2432 N N   . PHE A 1 370 ? 98.820  91.878  112.361 1.00 93.64  ? 370 PHE A N   1 
ATOM   2433 C CA  . PHE A 1 370 ? 97.994  91.573  113.524 1.00 100.94 ? 370 PHE A CA  1 
ATOM   2434 C C   . PHE A 1 370 ? 97.371  92.830  114.156 1.00 116.24 ? 370 PHE A C   1 
ATOM   2435 O O   . PHE A 1 370 ? 96.800  92.742  115.246 1.00 116.59 ? 370 PHE A O   1 
ATOM   2436 C CB  . PHE A 1 370 ? 98.811  90.794  114.554 1.00 106.56 ? 370 PHE A CB  1 
ATOM   2437 C CG  . PHE A 1 370 ? 99.088  89.353  114.193 1.00 134.09 ? 370 PHE A CG  1 
ATOM   2438 C CD1 . PHE A 1 370 ? 99.956  89.017  113.163 1.00 133.31 ? 370 PHE A CD1 1 
ATOM   2439 C CD2 . PHE A 1 370 ? 98.508  88.328  114.920 1.00 173.16 ? 370 PHE A CD2 1 
ATOM   2440 C CE1 . PHE A 1 370 ? 100.210 87.693  112.846 1.00 160.63 ? 370 PHE A CE1 1 
ATOM   2441 C CE2 . PHE A 1 370 ? 98.765  86.999  114.607 1.00 199.47 ? 370 PHE A CE2 1 
ATOM   2442 C CZ  . PHE A 1 370 ? 99.615  86.684  113.569 1.00 196.86 ? 370 PHE A CZ  1 
ATOM   2443 N N   . SER A 1 371 ? 97.399  93.973  113.447 1.00 131.71 ? 371 SER A N   1 
ATOM   2444 C CA  . SER A 1 371 ? 96.847  95.230  113.936 1.00 145.34 ? 371 SER A CA  1 
ATOM   2445 C C   . SER A 1 371 ? 95.320  95.186  113.985 1.00 147.86 ? 371 SER A C   1 
ATOM   2446 O O   . SER A 1 371 ? 94.708  95.745  114.903 1.00 161.10 ? 371 SER A O   1 
ATOM   2447 C CB  . SER A 1 371 ? 97.331  96.383  113.081 1.00 168.63 ? 371 SER A CB  1 
ATOM   2448 O OG  . SER A 1 371 ? 96.944  97.635  113.626 1.00 187.39 ? 371 SER A OG  1 
ATOM   2449 N N   . GLY A 1 372 ? 94.704  94.521  112.991 1.00 165.44 ? 372 GLY A N   1 
ATOM   2450 C CA  . GLY A 1 372 ? 93.253  94.458  112.864 1.00 185.68 ? 372 GLY A CA  1 
ATOM   2451 C C   . GLY A 1 372 ? 92.547  93.967  114.127 1.00 188.01 ? 372 GLY A C   1 
ATOM   2452 O O   . GLY A 1 372 ? 91.557  94.562  114.553 1.00 178.16 ? 372 GLY A O   1 
ATOM   2453 N N   . LEU A 1 373 ? 93.074  92.897  114.738 1.00 168.43 ? 373 LEU A N   1 
ATOM   2454 C CA  . LEU A 1 373 ? 92.406  92.239  115.856 1.00 165.95 ? 373 LEU A CA  1 
ATOM   2455 C C   . LEU A 1 373 ? 92.785  92.868  117.204 1.00 153.89 ? 373 LEU A C   1 
ATOM   2456 O O   . LEU A 1 373 ? 92.637  92.217  118.241 1.00 183.58 ? 373 LEU A O   1 
ATOM   2457 C CB  . LEU A 1 373 ? 92.656  90.716  115.809 1.00 151.58 ? 373 LEU A CB  1 
ATOM   2458 C CG  . LEU A 1 373 ? 94.095  90.213  115.700 1.00 154.70 ? 373 LEU A CG  1 
ATOM   2459 C CD1 . LEU A 1 373 ? 94.735  90.071  117.083 1.00 141.95 ? 373 LEU A CD1 1 
ATOM   2460 C CD2 . LEU A 1 373 ? 94.133  88.878  114.945 1.00 181.17 ? 373 LEU A CD2 1 
ATOM   2461 N N   . VAL A 1 374 ? 93.219  94.145  117.210 1.00 133.31 ? 374 VAL A N   1 
ATOM   2462 C CA  . VAL A 1 374 ? 93.203  94.962  118.426 1.00 127.67 ? 374 VAL A CA  1 
ATOM   2463 C C   . VAL A 1 374 ? 92.455  96.281  118.204 1.00 153.02 ? 374 VAL A C   1 
ATOM   2464 O O   . VAL A 1 374 ? 91.809  96.753  119.132 1.00 173.58 ? 374 VAL A O   1 
ATOM   2465 C CB  . VAL A 1 374 ? 94.599  95.211  119.042 1.00 113.06 ? 374 VAL A CB  1 
ATOM   2466 C CG1 . VAL A 1 374 ? 95.207  93.928  119.577 1.00 149.00 ? 374 VAL A CG1 1 
ATOM   2467 C CG2 . VAL A 1 374 ? 95.577  95.886  118.095 1.00 111.50 ? 374 VAL A CG2 1 
ATOM   2468 N N   . ILE A 1 375 ? 92.489  96.871  116.995 1.00 156.17 ? 375 ILE A N   1 
ATOM   2469 C CA  . ILE A 1 375 ? 91.902  98.192  116.768 1.00 136.60 ? 375 ILE A CA  1 
ATOM   2470 C C   . ILE A 1 375 ? 90.387  98.161  116.997 1.00 164.92 ? 375 ILE A C   1 
ATOM   2471 O O   . ILE A 1 375 ? 89.843  99.107  117.568 1.00 158.29 ? 375 ILE A O   1 
ATOM   2472 C CB  . ILE A 1 375 ? 92.296  98.764  115.389 1.00 149.45 ? 375 ILE A CB  1 
ATOM   2473 C CG1 . ILE A 1 375 ? 93.771  99.170  115.367 1.00 196.46 ? 375 ILE A CG1 1 
ATOM   2474 C CG2 . ILE A 1 375 ? 91.419  99.943  114.997 1.00 151.14 ? 375 ILE A CG2 1 
ATOM   2475 C CD1 . ILE A 1 375 ? 94.279  99.688  114.036 1.00 214.44 ? 375 ILE A CD1 1 
ATOM   2476 N N   . GLU A 1 376 ? 89.696  97.086  116.577 1.00 196.43 ? 376 GLU A N   1 
ATOM   2477 C CA  . GLU A 1 376 ? 88.249  97.011  116.740 1.00 214.72 ? 376 GLU A CA  1 
ATOM   2478 C C   . GLU A 1 376 ? 87.864  96.490  118.130 1.00 207.34 ? 376 GLU A C   1 
ATOM   2479 O O   . GLU A 1 376 ? 86.819  96.883  118.655 1.00 223.74 ? 376 GLU A O   1 
ATOM   2480 C CB  . GLU A 1 376 ? 87.604  96.200  115.611 1.00 241.76 ? 376 GLU A CB  1 
ATOM   2481 C CG  . GLU A 1 376 ? 87.898  94.705  115.623 1.00 246.78 ? 376 GLU A CG  1 
ATOM   2482 C CD  . GLU A 1 376 ? 87.331  93.950  114.425 1.00 278.37 ? 376 GLU A CD  1 
ATOM   2483 O OE1 . GLU A 1 376 ? 87.600  94.365  113.277 1.00 288.20 ? 376 GLU A OE1 1 
ATOM   2484 O OE2 . GLU A 1 376 ? 86.627  92.937  114.639 1.00 289.98 ? 376 GLU A OE2 1 
ATOM   2485 N N   . HIS A 1 377 ? 88.709  95.637  118.736 1.00 183.24 ? 377 HIS A N   1 
ATOM   2486 C CA  . HIS A 1 377 ? 88.399  94.985  120.004 1.00 164.42 ? 377 HIS A CA  1 
ATOM   2487 C C   . HIS A 1 377 ? 88.563  95.904  121.213 1.00 129.37 ? 377 HIS A C   1 
ATOM   2488 O O   . HIS A 1 377 ? 87.817  95.749  122.182 1.00 140.51 ? 377 HIS A O   1 
ATOM   2489 C CB  . HIS A 1 377 ? 89.222  93.704  120.171 1.00 177.25 ? 377 HIS A CB  1 
ATOM   2490 C CG  . HIS A 1 377 ? 88.803  92.632  119.219 1.00 226.41 ? 377 HIS A CG  1 
ATOM   2491 N ND1 . HIS A 1 377 ? 89.199  92.585  117.899 1.00 231.12 ? 377 HIS A ND1 1 
ATOM   2492 C CD2 . HIS A 1 377 ? 88.010  91.569  119.411 1.00 241.05 ? 377 HIS A CD2 1 
ATOM   2493 C CE1 . HIS A 1 377 ? 88.661  91.521  117.322 1.00 254.34 ? 377 HIS A CE1 1 
ATOM   2494 N NE2 . HIS A 1 377 ? 87.929  90.891  118.222 1.00 243.03 ? 377 HIS A NE2 1 
ATOM   2495 N N   . LEU A 1 378 ? 89.536  96.831  121.180 1.00 122.64 ? 378 LEU A N   1 
ATOM   2496 C CA  . LEU A 1 378 ? 89.862  97.648  122.346 1.00 144.50 ? 378 LEU A CA  1 
ATOM   2497 C C   . LEU A 1 378 ? 89.267  99.060  122.254 1.00 151.37 ? 378 LEU A C   1 
ATOM   2498 O O   . LEU A 1 378 ? 89.273  99.781  123.251 1.00 147.17 ? 378 LEU A O   1 
ATOM   2499 C CB  . LEU A 1 378 ? 91.385  97.722  122.503 1.00 139.98 ? 378 LEU A CB  1 
ATOM   2500 C CG  . LEU A 1 378 ? 92.102  96.409  122.794 1.00 152.71 ? 378 LEU A CG  1 
ATOM   2501 C CD1 . LEU A 1 378 ? 93.603  96.647  122.922 1.00 162.63 ? 378 LEU A CD1 1 
ATOM   2502 C CD2 . LEU A 1 378 ? 91.530  95.767  124.047 1.00 191.64 ? 378 LEU A CD2 1 
ATOM   2503 N N   . GLY A 1 379 ? 88.750  99.463  121.085 1.00 140.34 ? 379 GLY A N   1 
ATOM   2504 C CA  . GLY A 1 379 ? 88.275  100.829 120.904 1.00 137.72 ? 379 GLY A CA  1 
ATOM   2505 C C   . GLY A 1 379 ? 89.445  101.806 120.763 1.00 133.76 ? 379 GLY A C   1 
ATOM   2506 O O   . GLY A 1 379 ? 90.603  101.389 120.632 1.00 151.29 ? 379 GLY A O   1 
ATOM   2507 N N   . ARG A 1 380 ? 89.155  103.119 120.792 1.00 127.26 ? 380 ARG A N   1 
ATOM   2508 C CA  . ARG A 1 380 ? 90.145  104.116 120.417 1.00 114.02 ? 380 ARG A CA  1 
ATOM   2509 C C   . ARG A 1 380 ? 90.914  104.648 121.622 1.00 79.70  ? 380 ARG A C   1 
ATOM   2510 O O   . ARG A 1 380 ? 92.102  104.934 121.494 1.00 88.84  ? 380 ARG A O   1 
ATOM   2511 C CB  . ARG A 1 380 ? 89.486  105.278 119.661 1.00 144.16 ? 380 ARG A CB  1 
ATOM   2512 C CG  . ARG A 1 380 ? 89.342  105.052 118.160 1.00 142.39 ? 380 ARG A CG  1 
ATOM   2513 C CD  . ARG A 1 380 ? 88.548  103.815 117.755 1.00 117.93 ? 380 ARG A CD  1 
ATOM   2514 N NE  . ARG A 1 380 ? 87.786  104.052 116.531 1.00 123.54 ? 380 ARG A NE  1 
ATOM   2515 C CZ  . ARG A 1 380 ? 87.605  103.170 115.563 1.00 143.30 ? 380 ARG A CZ  1 
ATOM   2516 N NH1 . ARG A 1 380 ? 86.934  103.503 114.474 1.00 207.48 ? 380 ARG A NH1 1 
ATOM   2517 N NH2 . ARG A 1 380 ? 88.095  101.958 115.670 1.00 137.81 ? 380 ARG A NH2 1 
ATOM   2518 N N   . ARG A 1 381 ? 90.268  104.791 122.788 1.00 80.73  ? 381 ARG A N   1 
ATOM   2519 C CA  . ARG A 1 381 ? 90.868  105.508 123.907 1.00 100.53 ? 381 ARG A CA  1 
ATOM   2520 C C   . ARG A 1 381 ? 92.054  104.754 124.529 1.00 95.86  ? 381 ARG A C   1 
ATOM   2521 O O   . ARG A 1 381 ? 93.112  105.351 124.714 1.00 71.20  ? 381 ARG A O   1 
ATOM   2522 C CB  . ARG A 1 381 ? 89.790  105.874 124.934 1.00 97.00  ? 381 ARG A CB  1 
ATOM   2523 C CG  . ARG A 1 381 ? 90.287  106.687 126.117 1.00 83.13  ? 381 ARG A CG  1 
ATOM   2524 C CD  . ARG A 1 381 ? 89.136  107.174 126.941 1.00 94.29  ? 381 ARG A CD  1 
ATOM   2525 N NE  . ARG A 1 381 ? 89.535  107.667 128.244 1.00 93.17  ? 381 ARG A NE  1 
ATOM   2526 C CZ  . ARG A 1 381 ? 90.109  108.831 128.472 1.00 96.23  ? 381 ARG A CZ  1 
ATOM   2527 N NH1 . ARG A 1 381 ? 90.380  109.185 129.717 1.00 120.30 ? 381 ARG A NH1 1 
ATOM   2528 N NH2 . ARG A 1 381 ? 90.377  109.659 127.482 1.00 82.23  ? 381 ARG A NH2 1 
ATOM   2529 N N   . PRO A 1 382 ? 91.960  103.441 124.874 1.00 108.11 ? 382 PRO A N   1 
ATOM   2530 C CA  . PRO A 1 382 ? 93.106  102.732 125.438 1.00 103.40 ? 382 PRO A CA  1 
ATOM   2531 C C   . PRO A 1 382 ? 94.156  102.260 124.427 1.00 85.29  ? 382 PRO A C   1 
ATOM   2532 O O   . PRO A 1 382 ? 95.165  101.703 124.851 1.00 108.55 ? 382 PRO A O   1 
ATOM   2533 C CB  . PRO A 1 382 ? 92.448  101.542 126.147 1.00 122.90 ? 382 PRO A CB  1 
ATOM   2534 C CG  . PRO A 1 382 ? 91.253  101.231 125.264 1.00 143.88 ? 382 PRO A CG  1 
ATOM   2535 C CD  . PRO A 1 382 ? 90.762  102.584 124.790 1.00 134.61 ? 382 PRO A CD  1 
ATOM   2536 N N   . LEU A 1 383 ? 93.965  102.501 123.127 1.00 71.52  ? 383 LEU A N   1 
ATOM   2537 C CA  . LEU A 1 383 ? 95.043  102.344 122.157 1.00 70.32  ? 383 LEU A CA  1 
ATOM   2538 C C   . LEU A 1 383 ? 95.877  103.619 122.015 1.00 75.48  ? 383 LEU A C   1 
ATOM   2539 O O   . LEU A 1 383 ? 97.092  103.540 122.032 1.00 103.94 ? 383 LEU A O   1 
ATOM   2540 C CB  . LEU A 1 383 ? 94.508  101.907 120.793 1.00 66.53  ? 383 LEU A CB  1 
ATOM   2541 C CG  . LEU A 1 383 ? 94.194  100.426 120.666 1.00 90.34  ? 383 LEU A CG  1 
ATOM   2542 C CD1 . LEU A 1 383 ? 93.836  100.085 119.244 1.00 101.50 ? 383 LEU A CD1 1 
ATOM   2543 C CD2 . LEU A 1 383 ? 95.339  99.547  121.120 1.00 108.56 ? 383 LEU A CD2 1 
ATOM   2544 N N   . LEU A 1 384 ? 95.263  104.789 121.885 1.00 97.33  ? 384 LEU A N   1 
ATOM   2545 C CA  . LEU A 1 384 ? 96.028  106.022 121.758 1.00 97.95  ? 384 LEU A CA  1 
ATOM   2546 C C   . LEU A 1 384 ? 96.649  106.459 123.088 1.00 92.09  ? 384 LEU A C   1 
ATOM   2547 O O   . LEU A 1 384 ? 97.622  107.209 123.067 1.00 134.25 ? 384 LEU A O   1 
ATOM   2548 C CB  . LEU A 1 384 ? 95.124  107.122 121.161 1.00 95.97  ? 384 LEU A CB  1 
ATOM   2549 C CG  . LEU A 1 384 ? 95.286  107.318 119.664 1.00 89.68  ? 384 LEU A CG  1 
ATOM   2550 C CD1 . LEU A 1 384 ? 95.229  105.991 118.929 1.00 102.29 ? 384 LEU A CD1 1 
ATOM   2551 C CD2 . LEU A 1 384 ? 94.213  108.253 119.168 1.00 104.52 ? 384 LEU A CD2 1 
ATOM   2552 N N   . ILE A 1 385 ? 96.119  106.004 124.227 1.00 76.32  ? 385 ILE A N   1 
ATOM   2553 C CA  . ILE A 1 385 ? 96.800  106.207 125.498 1.00 83.75  ? 385 ILE A CA  1 
ATOM   2554 C C   . ILE A 1 385 ? 97.707  105.005 125.801 1.00 90.89  ? 385 ILE A C   1 
ATOM   2555 O O   . ILE A 1 385 ? 98.587  105.096 126.666 1.00 100.01 ? 385 ILE A O   1 
ATOM   2556 C CB  . ILE A 1 385 ? 95.763  106.490 126.606 1.00 92.20  ? 385 ILE A CB  1 
ATOM   2557 C CG1 . ILE A 1 385 ? 94.998  107.769 126.314 1.00 97.62  ? 385 ILE A CG1 1 
ATOM   2558 C CG2 . ILE A 1 385 ? 96.419  106.561 127.971 1.00 111.37 ? 385 ILE A CG2 1 
ATOM   2559 C CD1 . ILE A 1 385 ? 93.686  107.853 127.028 1.00 122.95 ? 385 ILE A CD1 1 
ATOM   2560 N N   . GLY A 1 386 ? 97.519  103.891 125.071 1.00 77.47  ? 386 GLY A N   1 
ATOM   2561 C CA  . GLY A 1 386 ? 98.376  102.727 125.182 1.00 73.86  ? 386 GLY A CA  1 
ATOM   2562 C C   . GLY A 1 386 ? 99.681  102.915 124.426 1.00 75.16  ? 386 GLY A C   1 
ATOM   2563 O O   . GLY A 1 386 ? 100.735 102.875 125.041 1.00 98.91  ? 386 GLY A O   1 
ATOM   2564 N N   . GLY A 1 387 ? 99.612  103.104 123.104 1.00 84.33  ? 387 GLY A N   1 
ATOM   2565 C CA  . GLY A 1 387 ? 100.773 103.285 122.256 1.00 92.65  ? 387 GLY A CA  1 
ATOM   2566 C C   . GLY A 1 387 ? 101.686 104.415 122.728 1.00 100.35 ? 387 GLY A C   1 
ATOM   2567 O O   . GLY A 1 387 ? 102.850 104.174 123.023 1.00 114.33 ? 387 GLY A O   1 
ATOM   2568 N N   . PHE A 1 388 ? 101.175 105.634 122.810 1.00 90.64  ? 388 PHE A N   1 
ATOM   2569 C CA  . PHE A 1 388 ? 101.958 106.774 123.263 1.00 85.67  ? 388 PHE A CA  1 
ATOM   2570 C C   . PHE A 1 388 ? 102.324 106.681 124.754 1.00 69.63  ? 388 PHE A C   1 
ATOM   2571 O O   . PHE A 1 388 ? 103.070 107.512 125.246 1.00 77.50  ? 388 PHE A O   1 
ATOM   2572 C CB  . PHE A 1 388 ? 101.210 108.083 122.971 1.00 91.78  ? 388 PHE A CB  1 
ATOM   2573 C CG  . PHE A 1 388 ? 100.843 108.330 121.528 1.00 97.53  ? 388 PHE A CG  1 
ATOM   2574 C CD1 . PHE A 1 388 ? 101.645 107.862 120.488 1.00 96.03  ? 388 PHE A CD1 1 
ATOM   2575 C CD2 . PHE A 1 388 ? 99.699  109.065 121.226 1.00 92.26  ? 388 PHE A CD2 1 
ATOM   2576 C CE1 . PHE A 1 388 ? 101.288 108.101 119.167 1.00 123.09 ? 388 PHE A CE1 1 
ATOM   2577 C CE2 . PHE A 1 388 ? 99.346  109.299 119.905 1.00 110.99 ? 388 PHE A CE2 1 
ATOM   2578 C CZ  . PHE A 1 388 ? 100.141 108.814 118.879 1.00 119.31 ? 388 PHE A CZ  1 
ATOM   2579 N N   . GLY A 1 389 ? 101.826 105.682 125.477 1.00 70.26  ? 389 GLY A N   1 
ATOM   2580 C CA  . GLY A 1 389 ? 102.246 105.397 126.837 1.00 80.01  ? 389 GLY A CA  1 
ATOM   2581 C C   . GLY A 1 389 ? 103.422 104.416 126.901 1.00 82.92  ? 389 GLY A C   1 
ATOM   2582 O O   . GLY A 1 389 ? 104.376 104.668 127.637 1.00 105.20 ? 389 GLY A O   1 
ATOM   2583 N N   . LEU A 1 390 ? 103.365 103.332 126.114 1.00 74.70  ? 390 LEU A N   1 
ATOM   2584 C CA  . LEU A 1 390 ? 104.425 102.337 126.076 1.00 86.44  ? 390 LEU A CA  1 
ATOM   2585 C C   . LEU A 1 390 ? 105.641 102.863 125.314 1.00 91.50  ? 390 LEU A C   1 
ATOM   2586 O O   . LEU A 1 390 ? 106.767 102.535 125.687 1.00 132.79 ? 390 LEU A O   1 
ATOM   2587 C CB  . LEU A 1 390 ? 103.930 101.021 125.452 1.00 86.32  ? 390 LEU A CB  1 
ATOM   2588 C CG  . LEU A 1 390 ? 102.968 100.213 126.309 1.00 96.85  ? 390 LEU A CG  1 
ATOM   2589 C CD1 . LEU A 1 390 ? 102.673 98.876  125.665 1.00 103.27 ? 390 LEU A CD1 1 
ATOM   2590 C CD2 . LEU A 1 390 ? 103.513 99.988  127.713 1.00 111.77 ? 390 LEU A CD2 1 
ATOM   2591 N N   . MET A 1 391 ? 105.458 103.685 124.277 1.00 67.78  ? 391 MET A N   1 
ATOM   2592 C CA  . MET A 1 391 ? 106.615 104.286 123.642 1.00 76.36  ? 391 MET A CA  1 
ATOM   2593 C C   . MET A 1 391 ? 107.366 105.180 124.639 1.00 79.50  ? 391 MET A C   1 
ATOM   2594 O O   . MET A 1 391 ? 108.570 105.374 124.504 1.00 114.39 ? 391 MET A O   1 
ATOM   2595 C CB  . MET A 1 391 ? 106.193 105.046 122.387 1.00 85.53  ? 391 MET A CB  1 
ATOM   2596 C CG  . MET A 1 391 ? 105.787 104.100 121.272 1.00 108.65 ? 391 MET A CG  1 
ATOM   2597 S SD  . MET A 1 391 ? 105.077 104.889 119.818 1.00 123.81 ? 391 MET A SD  1 
ATOM   2598 C CE  . MET A 1 391 ? 106.583 105.293 118.937 1.00 148.27 ? 391 MET A CE  1 
ATOM   2599 N N   . GLY A 1 392 ? 106.691 105.665 125.678 1.00 84.61  ? 392 GLY A N   1 
ATOM   2600 C CA  . GLY A 1 392 ? 107.343 106.356 126.778 1.00 85.34  ? 392 GLY A CA  1 
ATOM   2601 C C   . GLY A 1 392 ? 108.238 105.447 127.612 1.00 73.89  ? 392 GLY A C   1 
ATOM   2602 O O   . GLY A 1 392 ? 109.363 105.828 127.902 1.00 89.59  ? 392 GLY A O   1 
ATOM   2603 N N   . LEU A 1 393 ? 107.758 104.257 127.986 1.00 70.47  ? 393 LEU A N   1 
ATOM   2604 C CA  . LEU A 1 393 ? 108.549 103.294 128.738 1.00 89.25  ? 393 LEU A CA  1 
ATOM   2605 C C   . LEU A 1 393 ? 109.739 102.781 127.914 1.00 102.53 ? 393 LEU A C   1 
ATOM   2606 O O   . LEU A 1 393 ? 110.820 102.561 128.470 1.00 142.87 ? 393 LEU A O   1 
ATOM   2607 C CB  . LEU A 1 393 ? 107.656 102.132 129.179 1.00 98.40  ? 393 LEU A CB  1 
ATOM   2608 C CG  . LEU A 1 393 ? 108.365 100.962 129.857 1.00 111.92 ? 393 LEU A CG  1 
ATOM   2609 C CD1 . LEU A 1 393 ? 108.956 101.402 131.199 1.00 124.20 ? 393 LEU A CD1 1 
ATOM   2610 C CD2 . LEU A 1 393 ? 107.420 99.785  130.049 1.00 141.32 ? 393 LEU A CD2 1 
ATOM   2611 N N   . PHE A 1 394 ? 109.579 102.606 126.592 1.00 86.39  ? 394 PHE A N   1 
ATOM   2612 C CA  . PHE A 1 394 ? 110.634 102.005 125.793 1.00 78.49  ? 394 PHE A CA  1 
ATOM   2613 C C   . PHE A 1 394 ? 111.664 103.033 125.290 1.00 88.28  ? 394 PHE A C   1 
ATOM   2614 O O   . PHE A 1 394 ? 112.825 102.657 125.133 1.00 125.41 ? 394 PHE A O   1 
ATOM   2615 C CB  . PHE A 1 394 ? 110.029 101.115 124.709 1.00 76.81  ? 394 PHE A CB  1 
ATOM   2616 C CG  . PHE A 1 394 ? 109.209 99.974  125.252 1.00 89.57  ? 394 PHE A CG  1 
ATOM   2617 C CD1 . PHE A 1 394 ? 109.644 99.244  126.343 1.00 94.16  ? 394 PHE A CD1 1 
ATOM   2618 C CD2 . PHE A 1 394 ? 107.992 99.640  124.688 1.00 103.85 ? 394 PHE A CD2 1 
ATOM   2619 C CE1 . PHE A 1 394 ? 108.890 98.207  126.856 1.00 102.25 ? 394 PHE A CE1 1 
ATOM   2620 C CE2 . PHE A 1 394 ? 107.230 98.607  125.209 1.00 123.54 ? 394 PHE A CE2 1 
ATOM   2621 C CZ  . PHE A 1 394 ? 107.684 97.900  126.296 1.00 124.92 ? 394 PHE A CZ  1 
ATOM   2622 N N   . PHE A 1 395 ? 111.321 104.316 125.103 1.00 73.56  ? 395 PHE A N   1 
ATOM   2623 C CA  . PHE A 1 395 ? 112.346 105.331 124.928 1.00 67.26  ? 395 PHE A CA  1 
ATOM   2624 C C   . PHE A 1 395 ? 113.100 105.606 126.238 1.00 69.37  ? 395 PHE A C   1 
ATOM   2625 O O   . PHE A 1 395 ? 114.271 105.999 126.210 1.00 109.32 ? 395 PHE A O   1 
ATOM   2626 C CB  . PHE A 1 395 ? 111.754 106.625 124.364 1.00 81.52  ? 395 PHE A CB  1 
ATOM   2627 C CG  . PHE A 1 395 ? 111.371 106.573 122.904 1.00 91.06  ? 395 PHE A CG  1 
ATOM   2628 C CD1 . PHE A 1 395 ? 112.237 106.059 121.951 1.00 82.76  ? 395 PHE A CD1 1 
ATOM   2629 C CD2 . PHE A 1 395 ? 110.168 107.117 122.477 1.00 100.62 ? 395 PHE A CD2 1 
ATOM   2630 C CE1 . PHE A 1 395 ? 111.888 106.041 120.611 1.00 80.42  ? 395 PHE A CE1 1 
ATOM   2631 C CE2 . PHE A 1 395 ? 109.814 107.086 121.138 1.00 93.31  ? 395 PHE A CE2 1 
ATOM   2632 C CZ  . PHE A 1 395 ? 110.678 106.548 120.213 1.00 85.35  ? 395 PHE A CZ  1 
ATOM   2633 N N   . GLY A 1 396 ? 112.449 105.419 127.384 1.00 65.28  ? 396 GLY A N   1 
ATOM   2634 C CA  . GLY A 1 396 ? 113.128 105.433 128.667 1.00 88.67  ? 396 GLY A CA  1 
ATOM   2635 C C   . GLY A 1 396 ? 114.176 104.325 128.769 1.00 90.73  ? 396 GLY A C   1 
ATOM   2636 O O   . GLY A 1 396 ? 115.349 104.618 129.000 1.00 115.93 ? 396 GLY A O   1 
ATOM   2637 N N   . THR A 1 397 ? 113.773 103.051 128.627 1.00 72.65  ? 397 THR A N   1 
ATOM   2638 C CA  . THR A 1 397 ? 114.685 101.935 128.802 1.00 99.51  ? 397 THR A CA  1 
ATOM   2639 C C   . THR A 1 397 ? 115.703 101.825 127.660 1.00 108.54 ? 397 THR A C   1 
ATOM   2640 O O   . THR A 1 397 ? 116.805 101.314 127.881 1.00 145.09 ? 397 THR A O   1 
ATOM   2641 C CB  . THR A 1 397 ? 113.935 100.615 129.026 1.00 110.08 ? 397 THR A CB  1 
ATOM   2642 O OG1 . THR A 1 397 ? 112.970 100.414 127.991 1.00 110.05 ? 397 THR A OG1 1 
ATOM   2643 C CG2 . THR A 1 397 ? 113.272 100.589 130.390 1.00 121.80 ? 397 THR A CG2 1 
ATOM   2644 N N   . LEU A 1 398 ? 115.384 102.311 126.457 1.00 98.33  ? 398 LEU A N   1 
ATOM   2645 C CA  . LEU A 1 398 ? 116.401 102.461 125.425 1.00 87.69  ? 398 LEU A CA  1 
ATOM   2646 C C   . LEU A 1 398 ? 117.497 103.420 125.895 1.00 75.87  ? 398 LEU A C   1 
ATOM   2647 O O   . LEU A 1 398 ? 118.668 103.098 125.764 1.00 65.46  ? 398 LEU A O   1 
ATOM   2648 C CB  . LEU A 1 398 ? 115.754 102.939 124.114 1.00 85.71  ? 398 LEU A CB  1 
ATOM   2649 C CG  . LEU A 1 398 ? 116.701 103.240 122.963 1.00 80.45  ? 398 LEU A CG  1 
ATOM   2650 C CD1 . LEU A 1 398 ? 117.479 101.997 122.572 1.00 96.92  ? 398 LEU A CD1 1 
ATOM   2651 C CD2 . LEU A 1 398 ? 115.926 103.755 121.788 1.00 89.49  ? 398 LEU A CD2 1 
ATOM   2652 N N   . THR A 1 399 ? 117.140 104.581 126.466 1.00 80.19  ? 399 THR A N   1 
ATOM   2653 C CA  . THR A 1 399 ? 118.124 105.554 126.930 1.00 71.03  ? 399 THR A CA  1 
ATOM   2654 C C   . THR A 1 399 ? 119.016 105.000 128.045 1.00 60.30  ? 399 THR A C   1 
ATOM   2655 O O   . THR A 1 399 ? 120.164 105.401 128.160 1.00 58.77  ? 399 THR A O   1 
ATOM   2656 C CB  . THR A 1 399 ? 117.455 106.843 127.406 1.00 84.61  ? 399 THR A CB  1 
ATOM   2657 O OG1 . THR A 1 399 ? 116.744 107.411 126.303 1.00 102.76 ? 399 THR A OG1 1 
ATOM   2658 C CG2 . THR A 1 399 ? 118.442 107.849 127.955 1.00 95.91  ? 399 THR A CG2 1 
ATOM   2659 N N   . ILE A 1 400 ? 118.513 104.067 128.857 1.00 77.44  ? 400 ILE A N   1 
ATOM   2660 C CA  . ILE A 1 400 ? 119.349 103.365 129.820 1.00 99.23  ? 400 ILE A CA  1 
ATOM   2661 C C   . ILE A 1 400 ? 120.350 102.467 129.082 1.00 89.20  ? 400 ILE A C   1 
ATOM   2662 O O   . ILE A 1 400 ? 121.555 102.616 129.304 1.00 98.93  ? 400 ILE A O   1 
ATOM   2663 C CB  . ILE A 1 400 ? 118.495 102.585 130.845 1.00 128.88 ? 400 ILE A CB  1 
ATOM   2664 C CG1 . ILE A 1 400 ? 117.679 103.525 131.729 1.00 155.16 ? 400 ILE A CG1 1 
ATOM   2665 C CG2 . ILE A 1 400 ? 119.361 101.649 131.685 1.00 142.47 ? 400 ILE A CG2 1 
ATOM   2666 C CD1 . ILE A 1 400 ? 116.623 102.815 132.561 1.00 173.13 ? 400 ILE A CD1 1 
ATOM   2667 N N   . THR A 1 401 ? 119.889 101.577 128.186 1.00 83.26  ? 401 THR A N   1 
ATOM   2668 C CA  . THR A 1 401 ? 120.774 100.602 127.554 1.00 94.08  ? 401 THR A CA  1 
ATOM   2669 C C   . THR A 1 401 ? 121.773 101.252 126.579 1.00 97.51  ? 401 THR A C   1 
ATOM   2670 O O   . THR A 1 401 ? 122.841 100.695 126.370 1.00 113.65 ? 401 THR A O   1 
ATOM   2671 C CB  . THR A 1 401 ? 120.020 99.442  126.874 1.00 89.88  ? 401 THR A CB  1 
ATOM   2672 O OG1 . THR A 1 401 ? 119.117 99.908  125.882 1.00 108.16 ? 401 THR A OG1 1 
ATOM   2673 C CG2 . THR A 1 401 ? 119.235 98.610  127.847 1.00 114.32 ? 401 THR A CG2 1 
ATOM   2674 N N   . LEU A 1 402 ? 121.464 102.410 125.975 1.00 84.03  ? 402 LEU A N   1 
ATOM   2675 C CA  . LEU A 1 402 ? 122.457 103.139 125.195 1.00 72.81  ? 402 LEU A CA  1 
ATOM   2676 C C   . LEU A 1 402 ? 123.551 103.720 126.094 1.00 69.47  ? 402 LEU A C   1 
ATOM   2677 O O   . LEU A 1 402 ? 124.681 103.858 125.624 1.00 105.79 ? 402 LEU A O   1 
ATOM   2678 C CB  . LEU A 1 402 ? 121.804 104.288 124.411 1.00 77.06  ? 402 LEU A CB  1 
ATOM   2679 C CG  . LEU A 1 402 ? 120.903 103.913 123.243 1.00 92.55  ? 402 LEU A CG  1 
ATOM   2680 C CD1 . LEU A 1 402 ? 120.379 105.166 122.552 1.00 114.53 ? 402 LEU A CD1 1 
ATOM   2681 C CD2 . LEU A 1 402 ? 121.643 103.062 122.247 1.00 101.76 ? 402 LEU A CD2 1 
ATOM   2682 N N   . THR A 1 403 ? 123.237 104.112 127.339 1.00 73.60  ? 403 THR A N   1 
ATOM   2683 C CA  . THR A 1 403 ? 124.167 104.867 128.171 1.00 103.47 ? 403 THR A CA  1 
ATOM   2684 C C   . THR A 1 403 ? 125.074 103.942 128.987 1.00 90.43  ? 403 THR A C   1 
ATOM   2685 O O   . THR A 1 403 ? 126.236 104.290 129.239 1.00 113.67 ? 403 THR A O   1 
ATOM   2686 C CB  . THR A 1 403 ? 123.458 105.888 129.077 1.00 128.96 ? 403 THR A CB  1 
ATOM   2687 O OG1 . THR A 1 403 ? 122.608 106.701 128.268 1.00 120.57 ? 403 THR A OG1 1 
ATOM   2688 C CG2 . THR A 1 403 ? 124.419 106.804 129.815 1.00 127.46 ? 403 THR A CG2 1 
ATOM   2689 N N   . LEU A 1 404 ? 124.559 102.778 129.406 1.00 75.62  ? 404 LEU A N   1 
ATOM   2690 C CA  . LEU A 1 404 ? 125.370 101.777 130.092 1.00 96.18  ? 404 LEU A CA  1 
ATOM   2691 C C   . LEU A 1 404 ? 125.910 100.732 129.104 1.00 113.60 ? 404 LEU A C   1 
ATOM   2692 O O   . LEU A 1 404 ? 126.181 99.598  129.501 1.00 140.55 ? 404 LEU A O   1 
ATOM   2693 C CB  . LEU A 1 404 ? 124.510 101.093 131.165 1.00 111.51 ? 404 LEU A CB  1 
ATOM   2694 C CG  . LEU A 1 404 ? 123.825 102.011 132.173 1.00 117.37 ? 404 LEU A CG  1 
ATOM   2695 C CD1 . LEU A 1 404 ? 122.998 101.204 133.162 1.00 159.91 ? 404 LEU A CD1 1 
ATOM   2696 C CD2 . LEU A 1 404 ? 124.853 102.840 132.897 1.00 112.39 ? 404 LEU A CD2 1 
ATOM   2697 N N   . GLN A 1 405 ? 126.160 101.128 127.848 1.00 115.44 ? 405 GLN A N   1 
ATOM   2698 C CA  . GLN A 1 405 ? 126.455 100.209 126.750 1.00 129.72 ? 405 GLN A CA  1 
ATOM   2699 C C   . GLN A 1 405 ? 127.769 99.451  126.948 1.00 152.83 ? 405 GLN A C   1 
ATOM   2700 O O   . GLN A 1 405 ? 128.029 98.503  126.205 1.00 149.30 ? 405 GLN A O   1 
ATOM   2701 C CB  . GLN A 1 405 ? 126.487 100.957 125.413 1.00 117.79 ? 405 GLN A CB  1 
ATOM   2702 C CG  . GLN A 1 405 ? 127.546 102.049 125.328 1.00 137.52 ? 405 GLN A CG  1 
ATOM   2703 C CD  . GLN A 1 405 ? 127.652 102.660 123.952 1.00 163.19 ? 405 GLN A CD  1 
ATOM   2704 O OE1 . GLN A 1 405 ? 128.623 102.443 123.233 1.00 201.13 ? 405 GLN A OE1 1 
ATOM   2705 N NE2 . GLN A 1 405 ? 126.650 103.435 123.570 1.00 181.23 ? 405 GLN A NE2 1 
ATOM   2706 N N   . ASP A 1 406 ? 128.601 99.881  127.920 1.00 153.26 ? 406 ASP A N   1 
ATOM   2707 C CA  . ASP A 1 406 ? 129.901 99.263  128.171 1.00 173.53 ? 406 ASP A CA  1 
ATOM   2708 C C   . ASP A 1 406 ? 130.080 98.855  129.640 1.00 178.57 ? 406 ASP A C   1 
ATOM   2709 O O   . ASP A 1 406 ? 131.187 98.494  130.040 1.00 199.92 ? 406 ASP A O   1 
ATOM   2710 C CB  . ASP A 1 406 ? 131.044 100.163 127.681 1.00 210.16 ? 406 ASP A CB  1 
ATOM   2711 C CG  . ASP A 1 406 ? 131.092 101.566 128.270 1.00 251.61 ? 406 ASP A CG  1 
ATOM   2712 O OD1 . ASP A 1 406 ? 130.350 101.837 129.235 1.00 254.44 ? 406 ASP A OD1 1 
ATOM   2713 O OD2 . ASP A 1 406 ? 131.872 102.389 127.743 1.00 283.16 ? 406 ASP A OD2 1 
ATOM   2714 N N   . HIS A 1 407 ? 129.001 98.867  130.442 1.00 174.70 ? 407 HIS A N   1 
ATOM   2715 C CA  . HIS A 1 407 ? 129.025 98.324  131.797 1.00 183.13 ? 407 HIS A CA  1 
ATOM   2716 C C   . HIS A 1 407 ? 128.951 96.795  131.798 1.00 161.66 ? 407 HIS A C   1 
ATOM   2717 O O   . HIS A 1 407 ? 129.270 96.177  132.815 1.00 171.13 ? 407 HIS A O   1 
ATOM   2718 C CB  . HIS A 1 407 ? 127.910 98.934  132.660 1.00 213.06 ? 407 HIS A CB  1 
ATOM   2719 C CG  . HIS A 1 407 ? 128.216 100.306 133.186 1.00 253.61 ? 407 HIS A CG  1 
ATOM   2720 N ND1 . HIS A 1 407 ? 127.764 100.790 134.397 1.00 255.27 ? 407 HIS A ND1 1 
ATOM   2721 C CD2 . HIS A 1 407 ? 128.923 101.301 132.634 1.00 266.08 ? 407 HIS A CD2 1 
ATOM   2722 C CE1 . HIS A 1 407 ? 128.189 102.035 134.556 1.00 246.95 ? 407 HIS A CE1 1 
ATOM   2723 N NE2 . HIS A 1 407 ? 128.919 102.356 133.509 1.00 254.82 ? 407 HIS A NE2 1 
ATOM   2724 N N   . ALA A 1 408 ? 128.517 96.201  130.674 1.00 158.87 ? 408 ALA A N   1 
ATOM   2725 C CA  . ALA A 1 408 ? 128.528 94.755  130.480 1.00 191.91 ? 408 ALA A CA  1 
ATOM   2726 C C   . ALA A 1 408 ? 128.533 94.441  128.980 1.00 160.75 ? 408 ALA A C   1 
ATOM   2727 O O   . ALA A 1 408 ? 128.144 95.280  128.174 1.00 161.45 ? 408 ALA A O   1 
ATOM   2728 C CB  . ALA A 1 408 ? 127.335 94.155  131.193 1.00 237.26 ? 408 ALA A CB  1 
ATOM   2729 N N   . PRO A 1 409 ? 128.975 93.238  128.540 1.00 160.08 ? 409 PRO A N   1 
ATOM   2730 C CA  . PRO A 1 409 ? 129.048 92.925  127.110 1.00 169.01 ? 409 PRO A CA  1 
ATOM   2731 C C   . PRO A 1 409 ? 127.715 92.635  126.416 1.00 152.23 ? 409 PRO A C   1 
ATOM   2732 O O   . PRO A 1 409 ? 127.635 92.722  125.192 1.00 151.59 ? 409 PRO A O   1 
ATOM   2733 C CB  . PRO A 1 409 ? 129.952 91.679  127.073 1.00 191.43 ? 409 PRO A CB  1 
ATOM   2734 C CG  . PRO A 1 409 ? 129.717 91.007  128.404 1.00 191.36 ? 409 PRO A CG  1 
ATOM   2735 C CD  . PRO A 1 409 ? 129.480 92.139  129.380 1.00 176.22 ? 409 PRO A CD  1 
ATOM   2736 N N   . TRP A 1 410 ? 126.666 92.331  127.194 1.00 149.38 ? 410 TRP A N   1 
ATOM   2737 C CA  . TRP A 1 410 ? 125.383 91.893  126.647 1.00 158.03 ? 410 TRP A CA  1 
ATOM   2738 C C   . TRP A 1 410 ? 124.389 93.044  126.462 1.00 127.77 ? 410 TRP A C   1 
ATOM   2739 O O   . TRP A 1 410 ? 123.377 92.870  125.786 1.00 134.95 ? 410 TRP A O   1 
ATOM   2740 C CB  . TRP A 1 410 ? 124.763 90.789  127.528 1.00 198.49 ? 410 TRP A CB  1 
ATOM   2741 C CG  . TRP A 1 410 ? 124.904 91.001  129.016 1.00 185.50 ? 410 TRP A CG  1 
ATOM   2742 C CD1 . TRP A 1 410 ? 125.844 90.415  129.813 1.00 192.84 ? 410 TRP A CD1 1 
ATOM   2743 C CD2 . TRP A 1 410 ? 124.096 91.825  129.890 1.00 143.54 ? 410 TRP A CD2 1 
ATOM   2744 N NE1 . TRP A 1 410 ? 125.695 90.818  131.111 1.00 178.43 ? 410 TRP A NE1 1 
ATOM   2745 C CE2 . TRP A 1 410 ? 124.631 91.681  131.191 1.00 168.35 ? 410 TRP A CE2 1 
ATOM   2746 C CE3 . TRP A 1 410 ? 122.990 92.663  129.713 1.00 143.01 ? 410 TRP A CE3 1 
ATOM   2747 C CZ2 . TRP A 1 410 ? 124.098 92.346  132.296 1.00 190.31 ? 410 TRP A CZ2 1 
ATOM   2748 C CZ3 . TRP A 1 410 ? 122.472 93.325  130.806 1.00 184.72 ? 410 TRP A CZ3 1 
ATOM   2749 C CH2 . TRP A 1 410 ? 123.019 93.169  132.078 1.00 194.25 ? 410 TRP A CH2 1 
ATOM   2750 N N   . VAL A 1 411 ? 124.670 94.229  127.028 1.00 121.19 ? 411 VAL A N   1 
ATOM   2751 C CA  . VAL A 1 411 ? 123.687 95.310  127.089 1.00 99.94  ? 411 VAL A CA  1 
ATOM   2752 C C   . VAL A 1 411 ? 123.288 95.785  125.694 1.00 79.60  ? 411 VAL A C   1 
ATOM   2753 O O   . VAL A 1 411 ? 122.100 95.987  125.469 1.00 92.46  ? 411 VAL A O   1 
ATOM   2754 C CB  . VAL A 1 411 ? 124.152 96.469  128.002 1.00 110.88 ? 411 VAL A CB  1 
ATOM   2755 C CG1 . VAL A 1 411 ? 123.356 97.745  127.808 1.00 101.74 ? 411 VAL A CG1 1 
ATOM   2756 C CG2 . VAL A 1 411 ? 124.099 96.059  129.460 1.00 130.35 ? 411 VAL A CG2 1 
ATOM   2757 N N   . PRO A 1 412 ? 124.200 96.037  124.718 1.00 101.79 ? 412 PRO A N   1 
ATOM   2758 C CA  . PRO A 1 412 ? 123.794 96.503  123.388 1.00 95.68  ? 412 PRO A CA  1 
ATOM   2759 C C   . PRO A 1 412 ? 122.685 95.697  122.716 1.00 105.71 ? 412 PRO A C   1 
ATOM   2760 O O   . PRO A 1 412 ? 121.852 96.268  122.018 1.00 100.08 ? 412 PRO A O   1 
ATOM   2761 C CB  . PRO A 1 412 ? 125.092 96.442  122.581 1.00 106.55 ? 412 PRO A CB  1 
ATOM   2762 C CG  . PRO A 1 412 ? 126.155 96.715  123.623 1.00 135.58 ? 412 PRO A CG  1 
ATOM   2763 C CD  . PRO A 1 412 ? 125.666 95.980  124.849 1.00 131.08 ? 412 PRO A CD  1 
ATOM   2764 N N   . TYR A 1 413 ? 122.629 94.378  122.958 1.00 126.29 ? 413 TYR A N   1 
ATOM   2765 C CA  . TYR A 1 413 ? 121.595 93.538  122.363 1.00 140.45 ? 413 TYR A CA  1 
ATOM   2766 C C   . TYR A 1 413 ? 120.228 93.731  123.039 1.00 106.16 ? 413 TYR A C   1 
ATOM   2767 O O   . TYR A 1 413 ? 119.221 93.315  122.475 1.00 107.85 ? 413 TYR A O   1 
ATOM   2768 C CB  . TYR A 1 413 ? 122.074 92.087  122.363 1.00 155.49 ? 413 TYR A CB  1 
ATOM   2769 C CG  . TYR A 1 413 ? 123.360 91.885  121.578 1.00 146.91 ? 413 TYR A CG  1 
ATOM   2770 C CD1 . TYR A 1 413 ? 123.354 91.758  120.197 1.00 136.66 ? 413 TYR A CD1 1 
ATOM   2771 C CD2 . TYR A 1 413 ? 124.588 91.855  122.227 1.00 186.11 ? 413 TYR A CD2 1 
ATOM   2772 C CE1 . TYR A 1 413 ? 124.526 91.553  119.484 1.00 170.51 ? 413 TYR A CE1 1 
ATOM   2773 C CE2 . TYR A 1 413 ? 125.769 91.649  121.527 1.00 213.82 ? 413 TYR A CE2 1 
ATOM   2774 C CZ  . TYR A 1 413 ? 125.739 91.496  120.151 1.00 185.82 ? 413 TYR A CZ  1 
ATOM   2775 O OH  . TYR A 1 413 ? 126.907 91.302  119.467 1.00 157.29 ? 413 TYR A OH  1 
ATOM   2776 N N   . LEU A 1 414 ? 120.170 94.378  124.213 1.00 91.07  ? 414 LEU A N   1 
ATOM   2777 C CA  . LEU A 1 414 ? 118.905 94.826  124.784 1.00 106.50 ? 414 LEU A CA  1 
ATOM   2778 C C   . LEU A 1 414 ? 118.435 96.144  124.153 1.00 120.95 ? 414 LEU A C   1 
ATOM   2779 O O   . LEU A 1 414 ? 117.246 96.452  124.237 1.00 154.46 ? 414 LEU A O   1 
ATOM   2780 C CB  . LEU A 1 414 ? 119.028 94.987  126.303 1.00 111.93 ? 414 LEU A CB  1 
ATOM   2781 C CG  . LEU A 1 414 ? 119.318 93.719  127.098 1.00 131.75 ? 414 LEU A CG  1 
ATOM   2782 C CD1 . LEU A 1 414 ? 119.336 94.046  128.593 1.00 134.13 ? 414 LEU A CD1 1 
ATOM   2783 C CD2 . LEU A 1 414 ? 118.302 92.628  126.778 1.00 150.76 ? 414 LEU A CD2 1 
ATOM   2784 N N   . SER A 1 415 ? 119.324 96.916  123.503 1.00 100.95 ? 415 SER A N   1 
ATOM   2785 C CA  . SER A 1 415 ? 118.891 98.089  122.753 1.00 79.78  ? 415 SER A CA  1 
ATOM   2786 C C   . SER A 1 415 ? 118.168 97.695  121.469 1.00 76.13  ? 415 SER A C   1 
ATOM   2787 O O   . SER A 1 415 ? 117.382 98.488  120.949 1.00 81.35  ? 415 SER A O   1 
ATOM   2788 C CB  . SER A 1 415 ? 120.034 99.019  122.453 1.00 97.40  ? 415 SER A CB  1 
ATOM   2789 O OG  . SER A 1 415 ? 120.680 99.427  123.650 1.00 104.77 ? 415 SER A OG  1 
ATOM   2790 N N   . ILE A 1 416 ? 118.417 96.479  120.953 1.00 81.91  ? 416 ILE A N   1 
ATOM   2791 C CA  . ILE A 1 416 ? 117.653 95.942  119.830 1.00 88.71  ? 416 ILE A CA  1 
ATOM   2792 C C   . ILE A 1 416 ? 116.227 95.646  120.297 1.00 96.29  ? 416 ILE A C   1 
ATOM   2793 O O   . ILE A 1 416 ? 115.269 96.102  119.690 1.00 104.89 ? 416 ILE A O   1 
ATOM   2794 C CB  . ILE A 1 416 ? 118.320 94.713  119.185 1.00 76.63  ? 416 ILE A CB  1 
ATOM   2795 C CG1 . ILE A 1 416 ? 119.759 94.982  118.754 1.00 91.28  ? 416 ILE A CG1 1 
ATOM   2796 C CG2 . ILE A 1 416 ? 117.491 94.251  117.997 1.00 70.28  ? 416 ILE A CG2 1 
ATOM   2797 C CD1 . ILE A 1 416 ? 120.532 93.738  118.384 1.00 116.27 ? 416 ILE A CD1 1 
ATOM   2798 N N   . VAL A 1 417 ? 116.087 94.899  121.396 1.00 93.57  ? 417 VAL A N   1 
ATOM   2799 C CA  . VAL A 1 417 ? 114.780 94.547  121.932 1.00 97.59  ? 417 VAL A CA  1 
ATOM   2800 C C   . VAL A 1 417 ? 114.008 95.814  122.325 1.00 92.10  ? 417 VAL A C   1 
ATOM   2801 O O   . VAL A 1 417 ? 112.799 95.888  122.093 1.00 110.30 ? 417 VAL A O   1 
ATOM   2802 C CB  . VAL A 1 417 ? 114.927 93.540  123.095 1.00 118.40 ? 417 VAL A CB  1 
ATOM   2803 C CG1 . VAL A 1 417 ? 113.639 93.323  123.885 1.00 146.90 ? 417 VAL A CG1 1 
ATOM   2804 C CG2 . VAL A 1 417 ? 115.469 92.213  122.574 1.00 137.96 ? 417 VAL A CG2 1 
ATOM   2805 N N   . GLY A 1 418 ? 114.685 96.814  122.905 1.00 82.63  ? 418 GLY A N   1 
ATOM   2806 C CA  . GLY A 1 418 ? 114.092 98.117  123.157 1.00 85.79  ? 418 GLY A CA  1 
ATOM   2807 C C   . GLY A 1 418 ? 113.470 98.752  121.907 1.00 75.58  ? 418 GLY A C   1 
ATOM   2808 O O   . GLY A 1 418 ? 112.335 99.191  121.949 1.00 61.07  ? 418 GLY A O   1 
ATOM   2809 N N   . ILE A 1 419 ? 114.203 98.799  120.782 1.00 72.56  ? 419 ILE A N   1 
ATOM   2810 C CA  . ILE A 1 419 ? 113.697 99.406  119.565 1.00 68.07  ? 419 ILE A CA  1 
ATOM   2811 C C   . ILE A 1 419 ? 112.625 98.539  118.896 1.00 75.58  ? 419 ILE A C   1 
ATOM   2812 O O   . ILE A 1 419 ? 111.670 99.089  118.355 1.00 84.01  ? 419 ILE A O   1 
ATOM   2813 C CB  . ILE A 1 419 ? 114.846 99.810  118.620 1.00 68.94  ? 419 ILE A CB  1 
ATOM   2814 C CG1 . ILE A 1 419 ? 115.574 101.013 119.209 1.00 75.20  ? 419 ILE A CG1 1 
ATOM   2815 C CG2 . ILE A 1 419 ? 114.353 100.114 117.208 1.00 79.95  ? 419 ILE A CG2 1 
ATOM   2816 C CD1 . ILE A 1 419 ? 116.736 101.500 118.389 1.00 100.28 ? 419 ILE A CD1 1 
ATOM   2817 N N   . LEU A 1 420 ? 112.708 97.208  118.983 1.00 79.25  ? 420 LEU A N   1 
ATOM   2818 C CA  . LEU A 1 420 ? 111.649 96.365  118.439 1.00 76.28  ? 420 LEU A CA  1 
ATOM   2819 C C   . LEU A 1 420 ? 110.346 96.564  119.223 1.00 77.25  ? 420 LEU A C   1 
ATOM   2820 O O   . LEU A 1 420 ? 109.275 96.531  118.626 1.00 78.63  ? 420 LEU A O   1 
ATOM   2821 C CB  . LEU A 1 420 ? 112.092 94.896  118.420 1.00 72.81  ? 420 LEU A CB  1 
ATOM   2822 C CG  . LEU A 1 420 ? 113.194 94.574  117.408 1.00 70.94  ? 420 LEU A CG  1 
ATOM   2823 C CD1 . LEU A 1 420 ? 113.513 93.088  117.376 1.00 88.00  ? 420 LEU A CD1 1 
ATOM   2824 C CD2 . LEU A 1 420 ? 112.822 95.038  116.027 1.00 61.12  ? 420 LEU A CD2 1 
ATOM   2825 N N   . ALA A 1 421 ? 110.395 96.813  120.537 1.00 83.93  ? 421 ALA A N   1 
ATOM   2826 C CA  . ALA A 1 421 ? 109.184 97.083  121.309 1.00 81.63  ? 421 ALA A CA  1 
ATOM   2827 C C   . ALA A 1 421 ? 108.610 98.465  121.013 1.00 60.38  ? 421 ALA A C   1 
ATOM   2828 O O   . ALA A 1 421 ? 107.409 98.648  121.120 1.00 72.75  ? 421 ALA A O   1 
ATOM   2829 C CB  . ALA A 1 421 ? 109.446 96.893  122.788 1.00 98.94  ? 421 ALA A CB  1 
ATOM   2830 N N   . ILE A 1 422 ? 109.434 99.438  120.616 1.00 72.58  ? 422 ILE A N   1 
ATOM   2831 C CA  . ILE A 1 422 ? 108.954 100.749 120.168 1.00 76.77  ? 422 ILE A CA  1 
ATOM   2832 C C   . ILE A 1 422 ? 108.186 100.600 118.853 1.00 60.35  ? 422 ILE A C   1 
ATOM   2833 O O   . ILE A 1 422 ? 107.168 101.227 118.667 1.00 73.67  ? 422 ILE A O   1 
ATOM   2834 C CB  . ILE A 1 422 ? 110.117 101.768 120.047 1.00 79.63  ? 422 ILE A CB  1 
ATOM   2835 C CG1 . ILE A 1 422 ? 110.637 102.183 121.411 1.00 88.84  ? 422 ILE A CG1 1 
ATOM   2836 C CG2 . ILE A 1 422 ? 109.748 102.985 119.245 1.00 75.64  ? 422 ILE A CG2 1 
ATOM   2837 C CD1 . ILE A 1 422 ? 112.067 102.667 121.394 1.00 91.22  ? 422 ILE A CD1 1 
ATOM   2838 N N   . ILE A 1 423 ? 108.669 99.783  117.926 1.00 64.40  ? 423 ILE A N   1 
ATOM   2839 C CA  . ILE A 1 423 ? 107.997 99.551  116.660 1.00 71.63  ? 423 ILE A CA  1 
ATOM   2840 C C   . ILE A 1 423 ? 106.694 98.788  116.913 1.00 83.37  ? 423 ILE A C   1 
ATOM   2841 O O   . ILE A 1 423 ? 105.643 99.181  116.419 1.00 102.20 ? 423 ILE A O   1 
ATOM   2842 C CB  . ILE A 1 423 ? 108.949 98.817  115.679 1.00 77.90  ? 423 ILE A CB  1 
ATOM   2843 C CG1 . ILE A 1 423 ? 110.097 99.735  115.249 1.00 68.10  ? 423 ILE A CG1 1 
ATOM   2844 C CG2 . ILE A 1 423 ? 108.213 98.211  114.484 1.00 67.73  ? 423 ILE A CG2 1 
ATOM   2845 C CD1 . ILE A 1 423 ? 111.337 98.987  114.818 1.00 61.15  ? 423 ILE A CD1 1 
ATOM   2846 N N   . ALA A 1 424 ? 106.726 97.685  117.679 1.00 70.86  ? 424 ALA A N   1 
ATOM   2847 C CA  . ALA A 1 424 ? 105.546 96.874  117.909 1.00 74.69  ? 424 ALA A CA  1 
ATOM   2848 C C   . ALA A 1 424 ? 104.501 97.582  118.786 1.00 78.46  ? 424 ALA A C   1 
ATOM   2849 O O   . ALA A 1 424 ? 103.333 97.218  118.735 1.00 108.96 ? 424 ALA A O   1 
ATOM   2850 C CB  . ALA A 1 424 ? 105.948 95.543  118.475 1.00 88.12  ? 424 ALA A CB  1 
ATOM   2851 N N   . SER A 1 425 ? 104.877 98.583  119.583 1.00 68.08  ? 425 SER A N   1 
ATOM   2852 C CA  . SER A 1 425 ? 103.924 99.397  120.340 1.00 80.93  ? 425 SER A CA  1 
ATOM   2853 C C   . SER A 1 425 ? 103.206 100.434 119.477 1.00 74.00  ? 425 SER A C   1 
ATOM   2854 O O   . SER A 1 425 ? 102.202 100.979 119.898 1.00 85.51  ? 425 SER A O   1 
ATOM   2855 C CB  . SER A 1 425 ? 104.576 100.112 121.505 1.00 85.75  ? 425 SER A CB  1 
ATOM   2856 O OG  . SER A 1 425 ? 105.111 99.183  122.429 1.00 124.60 ? 425 SER A OG  1 
ATOM   2857 N N   . PHE A 1 426 ? 103.750 100.747 118.307 1.00 90.87  ? 426 PHE A N   1 
ATOM   2858 C CA  . PHE A 1 426 ? 103.175 101.731 117.409 1.00 96.00  ? 426 PHE A CA  1 
ATOM   2859 C C   . PHE A 1 426 ? 102.137 101.062 116.499 1.00 114.59 ? 426 PHE A C   1 
ATOM   2860 O O   . PHE A 1 426 ? 101.018 101.558 116.412 1.00 143.49 ? 426 PHE A O   1 
ATOM   2861 C CB  . PHE A 1 426 ? 104.288 102.438 116.626 1.00 89.81  ? 426 PHE A CB  1 
ATOM   2862 C CG  . PHE A 1 426 ? 103.853 103.561 115.729 1.00 101.82 ? 426 PHE A CG  1 
ATOM   2863 C CD1 . PHE A 1 426 ? 103.793 104.856 116.210 1.00 96.44  ? 426 PHE A CD1 1 
ATOM   2864 C CD2 . PHE A 1 426 ? 103.567 103.332 114.381 1.00 116.19 ? 426 PHE A CD2 1 
ATOM   2865 C CE1 . PHE A 1 426 ? 103.413 105.899 115.387 1.00 106.10 ? 426 PHE A CE1 1 
ATOM   2866 C CE2 . PHE A 1 426 ? 103.199 104.374 113.548 1.00 109.93 ? 426 PHE A CE2 1 
ATOM   2867 C CZ  . PHE A 1 426 ? 103.135 105.658 114.057 1.00 119.03 ? 426 PHE A CZ  1 
ATOM   2868 N N   . CYS A 1 427 ? 102.463 99.927  115.856 1.00 86.08  ? 427 CYS A N   1 
ATOM   2869 C CA  . CYS A 1 427 ? 101.553 99.333  114.890 1.00 104.44 ? 427 CYS A CA  1 
ATOM   2870 C C   . CYS A 1 427 ? 100.413 98.529  115.527 1.00 112.33 ? 427 CYS A C   1 
ATOM   2871 O O   . CYS A 1 427 ? 99.290  98.552  115.017 1.00 131.34 ? 427 CYS A O   1 
ATOM   2872 C CB  . CYS A 1 427 ? 102.322 98.535  113.863 1.00 102.81 ? 427 CYS A CB  1 
ATOM   2873 S SG  . CYS A 1 427 ? 103.262 99.663  112.826 1.00 152.67 ? 427 CYS A SG  1 
ATOM   2874 N N   . SER A 1 428 ? 100.681 97.825  116.631 1.00 100.43 ? 428 SER A N   1 
ATOM   2875 C CA  . SER A 1 428 ? 99.608  97.305  117.456 1.00 106.78 ? 428 SER A CA  1 
ATOM   2876 C C   . SER A 1 428 ? 99.127  98.424  118.377 1.00 114.69 ? 428 SER A C   1 
ATOM   2877 O O   . SER A 1 428 ? 99.251  98.337  119.608 1.00 144.81 ? 428 SER A O   1 
ATOM   2878 C CB  . SER A 1 428 ? 100.059 96.087  118.238 1.00 159.06 ? 428 SER A CB  1 
ATOM   2879 O OG  . SER A 1 428 ? 100.422 95.022  117.377 1.00 146.16 ? 428 SER A OG  1 
ATOM   2880 N N   . GLY A 1 429 ? 98.528  99.459  117.759 1.00 104.43 ? 429 GLY A N   1 
ATOM   2881 C CA  . GLY A 1 429 ? 98.296  100.737 118.425 1.00 94.12  ? 429 GLY A CA  1 
ATOM   2882 C C   . GLY A 1 429 ? 98.039  101.877 117.447 1.00 74.77  ? 429 GLY A C   1 
ATOM   2883 O O   . GLY A 1 429 ? 97.340  101.667 116.460 1.00 91.87  ? 429 GLY A O   1 
ATOM   2884 N N   . PRO A 1 430 ? 98.589  103.087 117.682 1.00 75.24  ? 430 PRO A N   1 
ATOM   2885 C CA  . PRO A 1 430 ? 98.373  104.265 116.835 1.00 94.04  ? 430 PRO A CA  1 
ATOM   2886 C C   . PRO A 1 430 ? 98.584  104.165 115.319 1.00 91.24  ? 430 PRO A C   1 
ATOM   2887 O O   . PRO A 1 430 ? 98.086  105.017 114.602 1.00 108.64 ? 430 PRO A O   1 
ATOM   2888 C CB  . PRO A 1 430 ? 99.417  105.287 117.344 1.00 103.01 ? 430 PRO A CB  1 
ATOM   2889 C CG  . PRO A 1 430 ? 99.590  104.920 118.797 1.00 109.47 ? 430 PRO A CG  1 
ATOM   2890 C CD  . PRO A 1 430 ? 99.401  103.419 118.850 1.00 94.60  ? 430 PRO A CD  1 
ATOM   2891 N N   . GLY A 1 431 ? 99.280  103.134 114.832 1.00 93.03  ? 431 GLY A N   1 
ATOM   2892 C CA  . GLY A 1 431 ? 99.751  103.067 113.455 1.00 118.11 ? 431 GLY A CA  1 
ATOM   2893 C C   . GLY A 1 431 ? 98.735  103.480 112.389 1.00 136.51 ? 431 GLY A C   1 
ATOM   2894 O O   . GLY A 1 431 ? 99.119  104.115 111.399 1.00 181.44 ? 431 GLY A O   1 
ATOM   2895 N N   . GLY A 1 432 ? 97.457  103.098 112.566 1.00 139.33 ? 432 GLY A N   1 
ATOM   2896 C CA  . GLY A 1 432 ? 96.419  103.370 111.581 1.00 156.45 ? 432 GLY A CA  1 
ATOM   2897 C C   . GLY A 1 432 ? 95.285  104.279 112.073 1.00 137.73 ? 432 GLY A C   1 
ATOM   2898 O O   . GLY A 1 432 ? 94.403  104.619 111.283 1.00 148.41 ? 432 GLY A O   1 
ATOM   2899 N N   . ILE A 1 433 ? 95.300  104.697 113.354 1.00 98.57  ? 433 ILE A N   1 
ATOM   2900 C CA  . ILE A 1 433 ? 94.108  105.256 113.981 1.00 96.95  ? 433 ILE A CA  1 
ATOM   2901 C C   . ILE A 1 433 ? 93.913  106.756 113.714 1.00 119.61 ? 433 ILE A C   1 
ATOM   2902 O O   . ILE A 1 433 ? 92.774  107.159 113.476 1.00 144.45 ? 433 ILE A O   1 
ATOM   2903 C CB  . ILE A 1 433 ? 94.021  104.893 115.477 1.00 101.58 ? 433 ILE A CB  1 
ATOM   2904 C CG1 . ILE A 1 433 ? 93.648  103.412 115.627 1.00 139.91 ? 433 ILE A CG1 1 
ATOM   2905 C CG2 . ILE A 1 433 ? 93.031  105.797 116.223 1.00 105.98 ? 433 ILE A CG2 1 
ATOM   2906 C CD1 . ILE A 1 433 ? 93.414  102.962 117.048 1.00 176.59 ? 433 ILE A CD1 1 
ATOM   2907 N N   . PRO A 1 434 ? 94.931  107.654 113.771 1.00 126.99 ? 434 PRO A N   1 
ATOM   2908 C CA  . PRO A 1 434 ? 94.697  109.088 113.573 1.00 128.05 ? 434 PRO A CA  1 
ATOM   2909 C C   . PRO A 1 434 ? 93.926  109.524 112.324 1.00 116.90 ? 434 PRO A C   1 
ATOM   2910 O O   . PRO A 1 434 ? 93.132  110.464 112.412 1.00 111.00 ? 434 PRO A O   1 
ATOM   2911 C CB  . PRO A 1 434 ? 96.126  109.645 113.576 1.00 127.98 ? 434 PRO A CB  1 
ATOM   2912 C CG  . PRO A 1 434 ? 96.851  108.752 114.528 1.00 116.47 ? 434 PRO A CG  1 
ATOM   2913 C CD  . PRO A 1 434 ? 96.320  107.382 114.166 1.00 131.98 ? 434 PRO A CD  1 
ATOM   2914 N N   . PHE A 1 435 ? 94.124  108.841 111.178 1.00 112.59 ? 435 PHE A N   1 
ATOM   2915 C CA  . PHE A 1 435 ? 93.367  109.147 109.972 1.00 112.18 ? 435 PHE A CA  1 
ATOM   2916 C C   . PHE A 1 435 ? 91.937  108.595 110.018 1.00 112.20 ? 435 PHE A C   1 
ATOM   2917 O O   . PHE A 1 435 ? 91.087  109.042 109.248 1.00 109.88 ? 435 PHE A O   1 
ATOM   2918 C CB  . PHE A 1 435 ? 94.129  108.658 108.743 1.00 151.73 ? 435 PHE A CB  1 
ATOM   2919 C CG  . PHE A 1 435 ? 95.177  109.625 108.258 1.00 206.07 ? 435 PHE A CG  1 
ATOM   2920 C CD1 . PHE A 1 435 ? 94.808  110.814 107.639 1.00 223.16 ? 435 PHE A CD1 1 
ATOM   2921 C CD2 . PHE A 1 435 ? 96.526  109.365 108.450 1.00 249.82 ? 435 PHE A CD2 1 
ATOM   2922 C CE1 . PHE A 1 435 ? 95.767  111.716 107.200 1.00 240.14 ? 435 PHE A CE1 1 
ATOM   2923 C CE2 . PHE A 1 435 ? 97.482  110.266 108.003 1.00 284.71 ? 435 PHE A CE2 1 
ATOM   2924 C CZ  . PHE A 1 435 ? 97.103  111.441 107.384 1.00 268.03 ? 435 PHE A CZ  1 
ATOM   2925 N N   . ILE A 1 436 ? 91.658  107.624 110.904 1.00 105.71 ? 436 ILE A N   1 
ATOM   2926 C CA  . ILE A 1 436 ? 90.297  107.190 111.178 1.00 100.53 ? 436 ILE A CA  1 
ATOM   2927 C C   . ILE A 1 436 ? 89.612  108.218 112.076 1.00 86.92  ? 436 ILE A C   1 
ATOM   2928 O O   . ILE A 1 436 ? 88.538  108.706 111.707 1.00 80.70  ? 436 ILE A O   1 
ATOM   2929 C CB  . ILE A 1 436 ? 90.273  105.749 111.734 1.00 118.25 ? 436 ILE A CB  1 
ATOM   2930 C CG1 . ILE A 1 436 ? 90.616  104.747 110.621 1.00 141.03 ? 436 ILE A CG1 1 
ATOM   2931 C CG2 . ILE A 1 436 ? 88.943  105.414 112.397 1.00 133.60 ? 436 ILE A CG2 1 
ATOM   2932 C CD1 . ILE A 1 436 ? 90.676  103.303 111.068 1.00 179.64 ? 436 ILE A CD1 1 
ATOM   2933 N N   . LEU A 1 437 ? 90.239  108.587 113.209 1.00 99.27  ? 437 LEU A N   1 
ATOM   2934 C CA  . LEU A 1 437 ? 89.658  109.544 114.150 1.00 105.76 ? 437 LEU A CA  1 
ATOM   2935 C C   . LEU A 1 437 ? 89.359  110.894 113.483 1.00 113.42 ? 437 LEU A C   1 
ATOM   2936 O O   . LEU A 1 437 ? 88.347  111.510 113.804 1.00 110.00 ? 437 LEU A O   1 
ATOM   2937 C CB  . LEU A 1 437 ? 90.590  109.756 115.345 1.00 103.47 ? 437 LEU A CB  1 
ATOM   2938 C CG  . LEU A 1 437 ? 90.404  108.821 116.529 1.00 116.90 ? 437 LEU A CG  1 
ATOM   2939 C CD1 . LEU A 1 437 ? 91.316  109.254 117.663 1.00 129.63 ? 437 LEU A CD1 1 
ATOM   2940 C CD2 . LEU A 1 437 ? 88.961  108.798 116.998 1.00 119.02 ? 437 LEU A CD2 1 
ATOM   2941 N N   . THR A 1 438 ? 90.237  111.369 112.590 1.00 115.10 ? 438 THR A N   1 
ATOM   2942 C CA  . THR A 1 438 ? 89.992  112.605 111.862 1.00 111.62 ? 438 THR A CA  1 
ATOM   2943 C C   . THR A 1 438 ? 88.612  112.577 111.205 1.00 111.78 ? 438 THR A C   1 
ATOM   2944 O O   . THR A 1 438 ? 87.984  113.618 111.044 1.00 125.84 ? 438 THR A O   1 
ATOM   2945 C CB  . THR A 1 438 ? 91.094  112.869 110.820 1.00 133.59 ? 438 THR A CB  1 
ATOM   2946 O OG1 . THR A 1 438 ? 92.363  112.928 111.470 1.00 158.94 ? 438 THR A OG1 1 
ATOM   2947 C CG2 . THR A 1 438 ? 90.908  114.163 110.049 1.00 127.78 ? 438 THR A CG2 1 
ATOM   2948 N N   . GLY A 1 439 ? 88.156  111.393 110.762 1.00 108.66 ? 439 GLY A N   1 
ATOM   2949 C CA  . GLY A 1 439 ? 86.840  111.236 110.158 1.00 126.34 ? 439 GLY A CA  1 
ATOM   2950 C C   . GLY A 1 439 ? 85.702  111.207 111.183 1.00 134.47 ? 439 GLY A C   1 
ATOM   2951 O O   . GLY A 1 439 ? 84.639  111.763 110.923 1.00 174.90 ? 439 GLY A O   1 
ATOM   2952 N N   . GLU A 1 440 ? 85.905  110.575 112.350 1.00 113.58 ? 440 GLU A N   1 
ATOM   2953 C CA  . GLU A 1 440 ? 84.803  110.272 113.250 1.00 102.85 ? 440 GLU A CA  1 
ATOM   2954 C C   . GLU A 1 440 ? 84.428  111.465 114.135 1.00 105.54 ? 440 GLU A C   1 
ATOM   2955 O O   . GLU A 1 440 ? 83.367  111.440 114.750 1.00 130.19 ? 440 GLU A O   1 
ATOM   2956 C CB  . GLU A 1 440 ? 85.130  109.007 114.053 1.00 151.79 ? 440 GLU A CB  1 
ATOM   2957 C CG  . GLU A 1 440 ? 85.263  107.770 113.169 1.00 212.97 ? 440 GLU A CG  1 
ATOM   2958 C CD  . GLU A 1 440 ? 85.324  106.412 113.857 1.00 236.07 ? 440 GLU A CD  1 
ATOM   2959 O OE1 . GLU A 1 440 ? 86.187  106.221 114.752 1.00 225.30 ? 440 GLU A OE1 1 
ATOM   2960 O OE2 . GLU A 1 440 ? 84.511  105.529 113.484 1.00 242.47 ? 440 GLU A OE2 1 
ATOM   2961 N N   . PHE A 1 441 ? 85.240  112.537 114.184 1.00 98.00  ? 441 PHE A N   1 
ATOM   2962 C CA  . PHE A 1 441 ? 84.896  113.729 114.963 1.00 93.31  ? 441 PHE A CA  1 
ATOM   2963 C C   . PHE A 1 441 ? 83.995  114.718 114.203 1.00 106.48 ? 441 PHE A C   1 
ATOM   2964 O O   . PHE A 1 441 ? 83.370  115.561 114.838 1.00 81.96  ? 441 PHE A O   1 
ATOM   2965 C CB  . PHE A 1 441 ? 86.152  114.516 115.341 1.00 104.02 ? 441 PHE A CB  1 
ATOM   2966 C CG  . PHE A 1 441 ? 87.105  113.870 116.325 1.00 94.97  ? 441 PHE A CG  1 
ATOM   2967 C CD1 . PHE A 1 441 ? 86.669  113.342 117.508 1.00 92.50  ? 441 PHE A CD1 1 
ATOM   2968 C CD2 . PHE A 1 441 ? 88.470  113.873 116.098 1.00 114.59 ? 441 PHE A CD2 1 
ATOM   2969 C CE1 . PHE A 1 441 ? 87.557  112.796 118.418 1.00 93.53  ? 441 PHE A CE1 1 
ATOM   2970 C CE2 . PHE A 1 441 ? 89.357  113.333 117.007 1.00 111.56 ? 441 PHE A CE2 1 
ATOM   2971 C CZ  . PHE A 1 441 ? 88.893  112.804 118.169 1.00 105.54 ? 441 PHE A CZ  1 
ATOM   2972 N N   . PHE A 1 442 ? 83.910  114.616 112.855 1.00 132.18 ? 442 PHE A N   1 
ATOM   2973 C CA  . PHE A 1 442 ? 83.401  115.681 111.985 1.00 106.42 ? 442 PHE A CA  1 
ATOM   2974 C C   . PHE A 1 442 ? 82.335  115.198 110.981 1.00 119.29 ? 442 PHE A C   1 
ATOM   2975 O O   . PHE A 1 442 ? 82.434  114.106 110.431 1.00 94.47  ? 442 PHE A O   1 
ATOM   2976 C CB  . PHE A 1 442 ? 84.558  116.281 111.169 1.00 92.13  ? 442 PHE A CB  1 
ATOM   2977 C CG  . PHE A 1 442 ? 85.619  117.032 111.939 1.00 86.83  ? 442 PHE A CG  1 
ATOM   2978 C CD1 . PHE A 1 442 ? 85.312  118.149 112.690 1.00 100.65 ? 442 PHE A CD1 1 
ATOM   2979 C CD2 . PHE A 1 442 ? 86.949  116.668 111.865 1.00 92.91  ? 442 PHE A CD2 1 
ATOM   2980 C CE1 . PHE A 1 442 ? 86.290  118.850 113.378 1.00 99.06  ? 442 PHE A CE1 1 
ATOM   2981 C CE2 . PHE A 1 442 ? 87.929  117.369 112.547 1.00 100.12 ? 442 PHE A CE2 1 
ATOM   2982 C CZ  . PHE A 1 442 ? 87.600  118.454 113.308 1.00 93.56  ? 442 PHE A CZ  1 
ATOM   2983 N N   . GLN A 1 443 ? 81.347  116.061 110.676 1.00 123.34 ? 443 GLN A N   1 
ATOM   2984 C CA  . GLN A 1 443 ? 80.350  115.824 109.630 1.00 126.79 ? 443 GLN A CA  1 
ATOM   2985 C C   . GLN A 1 443 ? 80.936  116.030 108.229 1.00 110.31 ? 443 GLN A C   1 
ATOM   2986 O O   . GLN A 1 443 ? 81.932  116.718 108.088 1.00 136.48 ? 443 GLN A O   1 
ATOM   2987 C CB  . GLN A 1 443 ? 79.181  116.814 109.741 1.00 125.76 ? 443 GLN A CB  1 
ATOM   2988 C CG  . GLN A 1 443 ? 78.540  116.939 111.115 1.00 146.81 ? 443 GLN A CG  1 
ATOM   2989 C CD  . GLN A 1 443 ? 77.478  118.011 111.133 1.00 154.76 ? 443 GLN A CD  1 
ATOM   2990 O OE1 . GLN A 1 443 ? 77.010  118.455 110.088 1.00 179.60 ? 443 GLN A OE1 1 
ATOM   2991 N NE2 . GLN A 1 443 ? 77.097  118.453 112.321 1.00 167.94 ? 443 GLN A NE2 1 
ATOM   2992 N N   . GLN A 1 444 ? 80.266  115.552 107.169 1.00 120.25 ? 444 GLN A N   1 
ATOM   2993 C CA  . GLN A 1 444 ? 80.724  115.774 105.793 1.00 127.29 ? 444 GLN A CA  1 
ATOM   2994 C C   . GLN A 1 444 ? 80.778  117.259 105.416 1.00 123.91 ? 444 GLN A C   1 
ATOM   2995 O O   . GLN A 1 444 ? 81.420  117.615 104.433 1.00 129.19 ? 444 GLN A O   1 
ATOM   2996 C CB  . GLN A 1 444 ? 79.834  115.035 104.785 1.00 181.52 ? 444 GLN A CB  1 
ATOM   2997 C CG  . GLN A 1 444 ? 80.165  113.554 104.625 1.00 230.24 ? 444 GLN A CG  1 
ATOM   2998 C CD  . GLN A 1 444 ? 81.486  113.314 103.929 1.00 259.81 ? 444 GLN A CD  1 
ATOM   2999 O OE1 . GLN A 1 444 ? 82.377  112.643 104.449 1.00 265.76 ? 444 GLN A OE1 1 
ATOM   3000 N NE2 . GLN A 1 444 ? 81.620  113.840 102.722 1.00 268.97 ? 444 GLN A NE2 1 
ATOM   3001 N N   . SER A 1 445 ? 80.122  118.136 106.194 1.00 155.29 ? 445 SER A N   1 
ATOM   3002 C CA  . SER A 1 445 ? 80.206  119.587 106.060 1.00 142.34 ? 445 SER A CA  1 
ATOM   3003 C C   . SER A 1 445 ? 81.615  120.111 106.378 1.00 115.45 ? 445 SER A C   1 
ATOM   3004 O O   . SER A 1 445 ? 82.078  121.079 105.767 1.00 112.35 ? 445 SER A O   1 
ATOM   3005 C CB  . SER A 1 445 ? 79.151  120.228 106.942 1.00 141.05 ? 445 SER A CB  1 
ATOM   3006 O OG  . SER A 1 445 ? 79.255  121.644 106.954 1.00 172.34 ? 445 SER A OG  1 
ATOM   3007 N N   . GLN A 1 446 ? 82.301  119.462 107.332 1.00 99.70  ? 446 GLN A N   1 
ATOM   3008 C CA  . GLN A 1 446 ? 83.571  119.922 107.878 1.00 106.18 ? 446 GLN A CA  1 
ATOM   3009 C C   . GLN A 1 446 ? 84.742  119.036 107.429 1.00 85.69  ? 446 GLN A C   1 
ATOM   3010 O O   . GLN A 1 446 ? 85.848  119.514 107.221 1.00 91.36  ? 446 GLN A O   1 
ATOM   3011 C CB  . GLN A 1 446 ? 83.474  119.929 109.411 1.00 95.02  ? 446 GLN A CB  1 
ATOM   3012 C CG  . GLN A 1 446 ? 82.481  120.951 109.954 1.00 92.72  ? 446 GLN A CG  1 
ATOM   3013 C CD  . GLN A 1 446 ? 81.878  120.554 111.278 1.00 96.02  ? 446 GLN A CD  1 
ATOM   3014 O OE1 . GLN A 1 446 ? 82.261  119.573 111.885 1.00 90.13  ? 446 GLN A OE1 1 
ATOM   3015 N NE2 . GLN A 1 446 ? 80.896  121.306 111.745 1.00 114.17 ? 446 GLN A NE2 1 
ATOM   3016 N N   . ARG A 1 447 ? 84.484  117.741 107.245 1.00 84.33  ? 447 ARG A N   1 
ATOM   3017 C CA  . ARG A 1 447 ? 85.499  116.707 107.107 1.00 94.40  ? 447 ARG A CA  1 
ATOM   3018 C C   . ARG A 1 447 ? 86.453  116.983 105.946 1.00 106.35 ? 447 ARG A C   1 
ATOM   3019 O O   . ARG A 1 447 ? 87.653  116.745 106.106 1.00 129.69 ? 447 ARG A O   1 
ATOM   3020 C CB  . ARG A 1 447 ? 84.800  115.344 106.995 1.00 103.13 ? 447 ARG A CB  1 
ATOM   3021 C CG  . ARG A 1 447 ? 85.712  114.137 107.043 1.00 120.09 ? 447 ARG A CG  1 
ATOM   3022 C CD  . ARG A 1 447 ? 84.919  112.853 106.863 1.00 151.60 ? 447 ARG A CD  1 
ATOM   3023 N NE  . ARG A 1 447 ? 84.042  112.575 107.994 1.00 137.77 ? 447 ARG A NE  1 
ATOM   3024 C CZ  . ARG A 1 447 ? 82.990  111.761 107.964 1.00 136.43 ? 447 ARG A CZ  1 
ATOM   3025 N NH1 . ARG A 1 447 ? 82.366  111.451 109.085 1.00 171.45 ? 447 ARG A NH1 1 
ATOM   3026 N NH2 . ARG A 1 447 ? 82.594  111.224 106.829 1.00 139.68 ? 447 ARG A NH2 1 
ATOM   3027 N N   . PRO A 1 448 ? 86.024  117.454 104.746 1.00 117.05 ? 448 PRO A N   1 
ATOM   3028 C CA  . PRO A 1 448 ? 86.964  117.737 103.660 1.00 110.63 ? 448 PRO A CA  1 
ATOM   3029 C C   . PRO A 1 448 ? 88.019  118.784 104.005 1.00 112.13 ? 448 PRO A C   1 
ATOM   3030 O O   . PRO A 1 448 ? 89.129  118.715 103.483 1.00 139.15 ? 448 PRO A O   1 
ATOM   3031 C CB  . PRO A 1 448 ? 86.078  118.225 102.505 1.00 142.28 ? 448 PRO A CB  1 
ATOM   3032 C CG  . PRO A 1 448 ? 84.717  117.638 102.812 1.00 173.37 ? 448 PRO A CG  1 
ATOM   3033 C CD  . PRO A 1 448 ? 84.630  117.664 104.326 1.00 155.74 ? 448 PRO A CD  1 
ATOM   3034 N N   . ALA A 1 449 ? 87.679  119.754 104.866 1.00 105.85 ? 449 ALA A N   1 
ATOM   3035 C CA  . ALA A 1 449 ? 88.629  120.749 105.338 1.00 96.02  ? 449 ALA A CA  1 
ATOM   3036 C C   . ALA A 1 449 ? 89.493  120.192 106.466 1.00 73.35  ? 449 ALA A C   1 
ATOM   3037 O O   . ALA A 1 449 ? 90.690  120.461 106.501 1.00 95.19  ? 449 ALA A O   1 
ATOM   3038 C CB  . ALA A 1 449 ? 87.901  122.007 105.750 1.00 102.01 ? 449 ALA A CB  1 
ATOM   3039 N N   . ALA A 1 450 ? 88.920  119.386 107.363 1.00 85.69  ? 450 ALA A N   1 
ATOM   3040 C CA  . ALA A 1 450 ? 89.677  118.798 108.462 1.00 101.29 ? 450 ALA A CA  1 
ATOM   3041 C C   . ALA A 1 450 ? 90.846  117.946 107.954 1.00 103.30 ? 450 ALA A C   1 
ATOM   3042 O O   . ALA A 1 450 ? 91.915  117.960 108.572 1.00 117.92 ? 450 ALA A O   1 
ATOM   3043 C CB  . ALA A 1 450 ? 88.779  117.990 109.357 1.00 103.21 ? 450 ALA A CB  1 
ATOM   3044 N N   . PHE A 1 451 ? 90.683  117.254 106.817 1.00 87.66  ? 451 PHE A N   1 
ATOM   3045 C CA  . PHE A 1 451 ? 91.755  116.448 106.258 1.00 105.67 ? 451 PHE A CA  1 
ATOM   3046 C C   . PHE A 1 451 ? 92.898  117.284 105.672 1.00 92.47  ? 451 PHE A C   1 
ATOM   3047 O O   . PHE A 1 451 ? 93.959  116.721 105.387 1.00 86.65  ? 451 PHE A O   1 
ATOM   3048 C CB  . PHE A 1 451 ? 91.194  115.476 105.211 1.00 134.86 ? 451 PHE A CB  1 
ATOM   3049 C CG  . PHE A 1 451 ? 90.525  114.249 105.786 1.00 126.07 ? 451 PHE A CG  1 
ATOM   3050 C CD1 . PHE A 1 451 ? 91.182  113.438 106.687 1.00 117.06 ? 451 PHE A CD1 1 
ATOM   3051 C CD2 . PHE A 1 451 ? 89.251  113.887 105.395 1.00 148.08 ? 451 PHE A CD2 1 
ATOM   3052 C CE1 . PHE A 1 451 ? 90.569  112.315 107.207 1.00 132.25 ? 451 PHE A CE1 1 
ATOM   3053 C CE2 . PHE A 1 451 ? 88.646  112.745 105.899 1.00 169.10 ? 451 PHE A CE2 1 
ATOM   3054 C CZ  . PHE A 1 451 ? 89.304  111.970 106.816 1.00 158.51 ? 451 PHE A CZ  1 
ATOM   3055 N N   . ILE A 1 452 ? 92.710  118.601 105.490 1.00 95.92  ? 452 ILE A N   1 
ATOM   3056 C CA  . ILE A 1 452 ? 93.803  119.480 105.087 1.00 88.52  ? 452 ILE A CA  1 
ATOM   3057 C C   . ILE A 1 452 ? 94.587  119.903 106.325 1.00 76.47  ? 452 ILE A C   1 
ATOM   3058 O O   . ILE A 1 452 ? 95.815  119.905 106.266 1.00 91.39  ? 452 ILE A O   1 
ATOM   3059 C CB  . ILE A 1 452 ? 93.304  120.658 104.220 1.00 86.94  ? 452 ILE A CB  1 
ATOM   3060 C CG1 . ILE A 1 452 ? 92.927  120.133 102.831 1.00 100.69 ? 452 ILE A CG1 1 
ATOM   3061 C CG2 . ILE A 1 452 ? 94.326  121.784 104.137 1.00 85.96  ? 452 ILE A CG2 1 
ATOM   3062 C CD1 . ILE A 1 452 ? 92.178  121.139 101.980 1.00 133.69 ? 452 ILE A CD1 1 
ATOM   3063 N N   . ILE A 1 453 ? 93.918  120.192 107.454 1.00 61.27  ? 453 ILE A N   1 
ATOM   3064 C CA  . ILE A 1 453 ? 94.610  120.493 108.707 1.00 60.67  ? 453 ILE A CA  1 
ATOM   3065 C C   . ILE A 1 453 ? 95.391  119.252 109.148 1.00 69.50  ? 453 ILE A C   1 
ATOM   3066 O O   . ILE A 1 453 ? 96.589  119.331 109.394 1.00 87.83  ? 453 ILE A O   1 
ATOM   3067 C CB  . ILE A 1 453 ? 93.647  120.954 109.816 1.00 63.05  ? 453 ILE A CB  1 
ATOM   3068 C CG1 . ILE A 1 453 ? 92.886  122.226 109.441 1.00 75.23  ? 453 ILE A CG1 1 
ATOM   3069 C CG2 . ILE A 1 453 ? 94.390  121.158 111.112 1.00 62.18  ? 453 ILE A CG2 1 
ATOM   3070 C CD1 . ILE A 1 453 ? 91.731  122.553 110.370 1.00 80.07  ? 453 ILE A CD1 1 
ATOM   3071 N N   . ALA A 1 454 ? 94.716  118.108 109.248 1.00 67.32  ? 454 ALA A N   1 
ATOM   3072 C CA  . ALA A 1 454 ? 95.322  116.884 109.739 1.00 65.97  ? 454 ALA A CA  1 
ATOM   3073 C C   . ALA A 1 454 ? 96.353  116.305 108.763 1.00 62.13  ? 454 ALA A C   1 
ATOM   3074 O O   . ALA A 1 454 ? 97.176  115.481 109.154 1.00 77.35  ? 454 ALA A O   1 
ATOM   3075 C CB  . ALA A 1 454 ? 94.211  115.881 110.033 1.00 88.83  ? 454 ALA A CB  1 
ATOM   3076 N N   . GLY A 1 455 ? 96.300  116.689 107.483 1.00 72.39  ? 455 GLY A N   1 
ATOM   3077 C CA  . GLY A 1 455 ? 97.314  116.321 106.497 1.00 78.51  ? 455 GLY A CA  1 
ATOM   3078 C C   . GLY A 1 455 ? 98.532  117.249 106.509 1.00 73.17  ? 455 GLY A C   1 
ATOM   3079 O O   . GLY A 1 455 ? 99.651  116.790 106.348 1.00 65.34  ? 455 GLY A O   1 
ATOM   3080 N N   . THR A 1 456 ? 98.314  118.557 106.738 1.00 67.60  ? 456 THR A N   1 
ATOM   3081 C CA  . THR A 1 456 ? 99.384  119.540 106.817 1.00 63.43  ? 456 THR A CA  1 
ATOM   3082 C C   . THR A 1 456 ? 100.227 119.343 108.075 1.00 58.93  ? 456 THR A C   1 
ATOM   3083 O O   . THR A 1 456 ? 101.440 119.454 108.001 1.00 73.74  ? 456 THR A O   1 
ATOM   3084 C CB  . THR A 1 456 ? 98.839  120.970 106.756 1.00 73.35  ? 456 THR A CB  1 
ATOM   3085 O OG1 . THR A 1 456 ? 98.178  121.116 105.485 1.00 70.62  ? 456 THR A OG1 1 
ATOM   3086 C CG2 . THR A 1 456 ? 99.888  122.046 106.973 1.00 79.38  ? 456 THR A CG2 1 
ATOM   3087 N N   . VAL A 1 457 ? 99.615  119.029 109.224 1.00 60.10  ? 457 VAL A N   1 
ATOM   3088 C CA  . VAL A 1 457 ? 100.366 118.828 110.462 1.00 62.00  ? 457 VAL A CA  1 
ATOM   3089 C C   . VAL A 1 457 ? 101.230 117.578 110.367 1.00 60.16  ? 457 VAL A C   1 
ATOM   3090 O O   . VAL A 1 457 ? 102.327 117.541 110.920 1.00 65.22  ? 457 VAL A O   1 
ATOM   3091 C CB  . VAL A 1 457 ? 99.437  118.767 111.693 1.00 68.71  ? 457 VAL A CB  1 
ATOM   3092 C CG1 . VAL A 1 457 ? 100.128 118.290 112.938 1.00 57.16  ? 457 VAL A CG1 1 
ATOM   3093 C CG2 . VAL A 1 457 ? 98.837  120.129 111.951 1.00 101.47 ? 457 VAL A CG2 1 
ATOM   3094 N N   . ASN A 1 458 ? 100.732 116.562 109.667 1.00 64.76  ? 458 ASN A N   1 
ATOM   3095 C CA  . ASN A 1 458 ? 101.438 115.305 109.481 1.00 71.02  ? 458 ASN A CA  1 
ATOM   3096 C C   . ASN A 1 458 ? 102.749 115.543 108.725 1.00 84.02  ? 458 ASN A C   1 
ATOM   3097 O O   . ASN A 1 458 ? 103.830 115.277 109.257 1.00 82.85  ? 458 ASN A O   1 
ATOM   3098 C CB  . ASN A 1 458 ? 100.540 114.292 108.780 1.00 76.51  ? 458 ASN A CB  1 
ATOM   3099 C CG  . ASN A 1 458 ? 101.085 112.887 108.877 1.00 118.88 ? 458 ASN A CG  1 
ATOM   3100 O OD1 . ASN A 1 458 ? 102.225 112.644 108.486 1.00 124.26 ? 458 ASN A OD1 1 
ATOM   3101 N ND2 . ASN A 1 458 ? 100.289 111.965 109.410 1.00 171.79 ? 458 ASN A ND2 1 
ATOM   3102 N N   . TRP A 1 459 ? 102.676 116.072 107.491 1.00 79.98  ? 459 TRP A N   1 
ATOM   3103 C CA  . TRP A 1 459 ? 103.865 116.251 106.672 1.00 64.63  ? 459 TRP A CA  1 
ATOM   3104 C C   . TRP A 1 459 ? 104.861 117.235 107.276 1.00 59.24  ? 459 TRP A C   1 
ATOM   3105 O O   . TRP A 1 459 ? 106.058 116.957 107.237 1.00 85.29  ? 459 TRP A O   1 
ATOM   3106 C CB  . TRP A 1 459 ? 103.469 116.644 105.254 1.00 64.94  ? 459 TRP A CB  1 
ATOM   3107 C CG  . TRP A 1 459 ? 102.845 115.507 104.484 1.00 80.59  ? 459 TRP A CG  1 
ATOM   3108 C CD1 . TRP A 1 459 ? 101.549 115.439 104.068 1.00 100.25 ? 459 TRP A CD1 1 
ATOM   3109 C CD2 . TRP A 1 459 ? 103.476 114.296 104.005 1.00 80.94  ? 459 TRP A CD2 1 
ATOM   3110 N NE1 . TRP A 1 459 ? 101.333 114.282 103.367 1.00 90.20  ? 459 TRP A NE1 1 
ATOM   3111 C CE2 . TRP A 1 459 ? 102.494 113.565 103.309 1.00 79.49  ? 459 TRP A CE2 1 
ATOM   3112 C CE3 . TRP A 1 459 ? 104.768 113.762 104.090 1.00 93.57  ? 459 TRP A CE3 1 
ATOM   3113 C CZ2 . TRP A 1 459 ? 102.769 112.339 102.703 1.00 106.65 ? 459 TRP A CZ2 1 
ATOM   3114 C CZ3 . TRP A 1 459 ? 105.044 112.559 103.485 1.00 105.23 ? 459 TRP A CZ3 1 
ATOM   3115 C CH2 . TRP A 1 459 ? 104.058 111.861 102.794 1.00 116.16 ? 459 TRP A CH2 1 
ATOM   3116 N N   . LEU A 1 460 ? 104.413 118.347 107.861 1.00 56.23  ? 460 LEU A N   1 
ATOM   3117 C CA  . LEU A 1 460 ? 105.332 119.263 108.527 1.00 59.65  ? 460 LEU A CA  1 
ATOM   3118 C C   . LEU A 1 460 ? 105.974 118.623 109.767 1.00 59.64  ? 460 LEU A C   1 
ATOM   3119 O O   . LEU A 1 460 ? 107.076 119.032 110.136 1.00 71.72  ? 460 LEU A O   1 
ATOM   3120 C CB  . LEU A 1 460 ? 104.623 120.565 108.896 1.00 68.04  ? 460 LEU A CB  1 
ATOM   3121 C CG  . LEU A 1 460 ? 104.224 121.452 107.727 1.00 93.94  ? 460 LEU A CG  1 
ATOM   3122 C CD1 . LEU A 1 460 ? 103.479 122.686 108.209 1.00 117.52 ? 460 LEU A CD1 1 
ATOM   3123 C CD2 . LEU A 1 460 ? 105.438 121.855 106.912 1.00 115.60 ? 460 LEU A CD2 1 
ATOM   3124 N N   . SER A 1 461 ? 105.338 117.623 110.395 1.00 57.37  ? 461 SER A N   1 
ATOM   3125 C CA  . SER A 1 461 ? 105.966 116.928 111.512 1.00 74.95  ? 461 SER A CA  1 
ATOM   3126 C C   . SER A 1 461 ? 106.938 115.838 111.042 1.00 74.88  ? 461 SER A C   1 
ATOM   3127 O O   . SER A 1 461 ? 107.945 115.594 111.696 1.00 72.80  ? 461 SER A O   1 
ATOM   3128 C CB  . SER A 1 461 ? 104.953 116.351 112.454 1.00 87.05  ? 461 SER A CB  1 
ATOM   3129 O OG  . SER A 1 461 ? 104.150 117.392 112.987 1.00 110.85 ? 461 SER A OG  1 
ATOM   3130 N N   . ASN A 1 462 ? 106.641 115.175 109.919 1.00 76.38  ? 462 ASN A N   1 
ATOM   3131 C CA  . ASN A 1 462 ? 107.569 114.235 109.308 1.00 68.21  ? 462 ASN A CA  1 
ATOM   3132 C C   . ASN A 1 462 ? 108.847 114.974 108.913 1.00 67.70  ? 462 ASN A C   1 
ATOM   3133 O O   . ASN A 1 462 ? 109.955 114.543 109.238 1.00 88.13  ? 462 ASN A O   1 
ATOM   3134 C CB  . ASN A 1 462 ? 106.884 113.519 108.144 1.00 82.53  ? 462 ASN A CB  1 
ATOM   3135 C CG  . ASN A 1 462 ? 107.688 112.401 107.530 1.00 92.74  ? 462 ASN A CG  1 
ATOM   3136 O OD1 . ASN A 1 462 ? 108.909 112.439 107.516 1.00 112.25 ? 462 ASN A OD1 1 
ATOM   3137 N ND2 . ASN A 1 462 ? 106.999 111.460 106.914 1.00 107.02 ? 462 ASN A ND2 1 
ATOM   3138 N N   . PHE A 1 463 ? 108.700 116.124 108.249 1.00 66.64  ? 463 PHE A N   1 
ATOM   3139 C CA  . PHE A 1 463 ? 109.811 117.014 107.942 1.00 76.01  ? 463 PHE A CA  1 
ATOM   3140 C C   . PHE A 1 463 ? 110.568 117.408 109.218 1.00 66.76  ? 463 PHE A C   1 
ATOM   3141 O O   . PHE A 1 463 ? 111.777 117.245 109.302 1.00 64.00  ? 463 PHE A O   1 
ATOM   3142 C CB  . PHE A 1 463 ? 109.273 118.245 107.206 1.00 87.19  ? 463 PHE A CB  1 
ATOM   3143 C CG  . PHE A 1 463 ? 110.301 119.304 106.900 1.00 89.49  ? 463 PHE A CG  1 
ATOM   3144 C CD1 . PHE A 1 463 ? 111.200 119.123 105.874 1.00 100.92 ? 463 PHE A CD1 1 
ATOM   3145 C CD2 . PHE A 1 463 ? 110.376 120.468 107.647 1.00 84.17  ? 463 PHE A CD2 1 
ATOM   3146 C CE1 . PHE A 1 463 ? 112.151 120.082 105.585 1.00 110.76 ? 463 PHE A CE1 1 
ATOM   3147 C CE2 . PHE A 1 463 ? 111.379 121.381 107.415 1.00 100.52 ? 463 PHE A CE2 1 
ATOM   3148 C CZ  . PHE A 1 463 ? 112.247 121.197 106.369 1.00 103.11 ? 463 PHE A CZ  1 
ATOM   3149 N N   . ALA A 1 464 ? 109.867 117.922 110.235 1.00 66.16  ? 464 ALA A N   1 
ATOM   3150 C CA  . ALA A 1 464 ? 110.520 118.472 111.402 1.00 73.28  ? 464 ALA A CA  1 
ATOM   3151 C C   . ALA A 1 464 ? 111.242 117.431 112.251 1.00 69.60  ? 464 ALA A C   1 
ATOM   3152 O O   . ALA A 1 464 ? 112.044 117.835 113.093 1.00 97.53  ? 464 ALA A O   1 
ATOM   3153 C CB  . ALA A 1 464 ? 109.504 119.218 112.239 1.00 119.54 ? 464 ALA A CB  1 
ATOM   3154 N N   . VAL A 1 465 ? 110.965 116.117 112.124 1.00 65.71  ? 465 VAL A N   1 
ATOM   3155 C CA  . VAL A 1 465 ? 111.735 115.094 112.837 1.00 71.00  ? 465 VAL A CA  1 
ATOM   3156 C C   . VAL A 1 465 ? 112.821 114.500 111.933 1.00 72.46  ? 465 VAL A C   1 
ATOM   3157 O O   . VAL A 1 465 ? 113.925 114.241 112.400 1.00 78.04  ? 465 VAL A O   1 
ATOM   3158 C CB  . VAL A 1 465 ? 110.856 113.996 113.481 1.00 81.39  ? 465 VAL A CB  1 
ATOM   3159 C CG1 . VAL A 1 465 ? 110.296 112.979 112.497 1.00 92.95  ? 465 VAL A CG1 1 
ATOM   3160 C CG2 . VAL A 1 465 ? 111.606 113.255 114.562 1.00 99.79  ? 465 VAL A CG2 1 
ATOM   3161 N N   . GLY A 1 466 ? 112.536 114.325 110.637 1.00 89.46  ? 466 GLY A N   1 
ATOM   3162 C CA  . GLY A 1 466 ? 113.514 113.843 109.670 1.00 90.04  ? 466 GLY A CA  1 
ATOM   3163 C C   . GLY A 1 466 ? 114.694 114.799 109.447 1.00 76.51  ? 466 GLY A C   1 
ATOM   3164 O O   . GLY A 1 466 ? 115.798 114.339 109.206 1.00 70.95  ? 466 GLY A O   1 
ATOM   3165 N N   . LEU A 1 467 ? 114.452 116.117 109.508 1.00 78.50  ? 467 LEU A N   1 
ATOM   3166 C CA  . LEU A 1 467 ? 115.490 117.127 109.338 1.00 80.07  ? 467 LEU A CA  1 
ATOM   3167 C C   . LEU A 1 467 ? 116.303 117.328 110.615 1.00 84.65  ? 467 LEU A C   1 
ATOM   3168 O O   . LEU A 1 467 ? 117.511 117.572 110.525 1.00 115.53 ? 467 LEU A O   1 
ATOM   3169 C CB  . LEU A 1 467 ? 114.868 118.465 108.907 1.00 93.20  ? 467 LEU A CB  1 
ATOM   3170 C CG  . LEU A 1 467 ? 115.811 119.668 108.841 1.00 79.51  ? 467 LEU A CG  1 
ATOM   3171 C CD1 . LEU A 1 467 ? 116.792 119.509 107.722 1.00 94.23  ? 467 LEU A CD1 1 
ATOM   3172 C CD2 . LEU A 1 467 ? 115.071 120.952 108.632 1.00 94.65  ? 467 LEU A CD2 1 
ATOM   3173 N N   . LEU A 1 468 ? 115.676 117.262 111.797 1.00 77.20  ? 468 LEU A N   1 
ATOM   3174 C CA  . LEU A 1 468 ? 116.368 117.621 113.030 1.00 86.01  ? 468 LEU A CA  1 
ATOM   3175 C C   . LEU A 1 468 ? 117.095 116.441 113.693 1.00 94.20  ? 468 LEU A C   1 
ATOM   3176 O O   . LEU A 1 468 ? 118.033 116.696 114.441 1.00 95.27  ? 468 LEU A O   1 
ATOM   3177 C CB  . LEU A 1 468 ? 115.388 118.252 114.012 1.00 99.78  ? 468 LEU A CB  1 
ATOM   3178 C CG  . LEU A 1 468 ? 115.385 119.771 114.013 1.00 125.57 ? 468 LEU A CG  1 
ATOM   3179 C CD1 . LEU A 1 468 ? 114.134 120.321 114.689 1.00 161.09 ? 468 LEU A CD1 1 
ATOM   3180 C CD2 . LEU A 1 468 ? 116.628 120.287 114.732 1.00 139.06 ? 468 LEU A CD2 1 
ATOM   3181 N N   . PHE A 1 469 ? 116.724 115.181 113.421 1.00 89.51  ? 469 PHE A N   1 
ATOM   3182 C CA  . PHE A 1 469 ? 117.230 114.075 114.227 1.00 84.06  ? 469 PHE A CA  1 
ATOM   3183 C C   . PHE A 1 469 ? 118.762 114.011 114.267 1.00 75.13  ? 469 PHE A C   1 
ATOM   3184 O O   . PHE A 1 469 ? 119.326 113.858 115.350 1.00 71.90  ? 469 PHE A O   1 
ATOM   3185 C CB  . PHE A 1 469 ? 116.628 112.725 113.821 1.00 88.15  ? 469 PHE A CB  1 
ATOM   3186 C CG  . PHE A 1 469 ? 117.029 111.600 114.736 1.00 89.16  ? 469 PHE A CG  1 
ATOM   3187 C CD1 . PHE A 1 469 ? 116.584 111.558 116.051 1.00 98.24  ? 469 PHE A CD1 1 
ATOM   3188 C CD2 . PHE A 1 469 ? 117.899 110.622 114.308 1.00 88.46  ? 469 PHE A CD2 1 
ATOM   3189 C CE1 . PHE A 1 469 ? 116.975 110.532 116.897 1.00 109.01 ? 469 PHE A CE1 1 
ATOM   3190 C CE2 . PHE A 1 469 ? 118.272 109.585 115.151 1.00 102.91 ? 469 PHE A CE2 1 
ATOM   3191 C CZ  . PHE A 1 469 ? 117.818 109.548 116.449 1.00 99.94  ? 469 PHE A CZ  1 
ATOM   3192 N N   . PRO A 1 470 ? 119.514 114.130 113.142 1.00 73.30  ? 470 PRO A N   1 
ATOM   3193 C CA  . PRO A 1 470 ? 120.979 114.127 113.193 1.00 65.98  ? 470 PRO A CA  1 
ATOM   3194 C C   . PRO A 1 470 ? 121.596 115.164 114.114 1.00 64.31  ? 470 PRO A C   1 
ATOM   3195 O O   . PRO A 1 470 ? 122.673 114.916 114.666 1.00 64.33  ? 470 PRO A O   1 
ATOM   3196 C CB  . PRO A 1 470 ? 121.385 114.380 111.739 1.00 65.09  ? 470 PRO A CB  1 
ATOM   3197 C CG  . PRO A 1 470 ? 120.237 113.791 110.958 1.00 79.82  ? 470 PRO A CG  1 
ATOM   3198 C CD  . PRO A 1 470 ? 119.023 114.197 111.758 1.00 73.99  ? 470 PRO A CD  1 
ATOM   3199 N N   . PHE A 1 471 ? 120.912 116.314 114.285 1.00 74.20  ? 471 PHE A N   1 
ATOM   3200 C CA  . PHE A 1 471 ? 121.404 117.413 115.106 1.00 88.47  ? 471 PHE A CA  1 
ATOM   3201 C C   . PHE A 1 471 ? 121.023 117.240 116.581 1.00 70.08  ? 471 PHE A C   1 
ATOM   3202 O O   . PHE A 1 471 ? 121.744 117.719 117.447 1.00 67.81  ? 471 PHE A O   1 
ATOM   3203 C CB  . PHE A 1 471 ? 120.903 118.735 114.530 1.00 110.81 ? 471 PHE A CB  1 
ATOM   3204 C CG  . PHE A 1 471 ? 121.412 119.033 113.142 1.00 135.34 ? 471 PHE A CG  1 
ATOM   3205 C CD1 . PHE A 1 471 ? 122.747 119.355 112.930 1.00 157.66 ? 471 PHE A CD1 1 
ATOM   3206 C CD2 . PHE A 1 471 ? 120.558 118.983 112.048 1.00 155.18 ? 471 PHE A CD2 1 
ATOM   3207 C CE1 . PHE A 1 471 ? 123.207 119.643 111.654 1.00 174.88 ? 471 PHE A CE1 1 
ATOM   3208 C CE2 . PHE A 1 471 ? 121.018 119.276 110.775 1.00 167.80 ? 471 PHE A CE2 1 
ATOM   3209 C CZ  . PHE A 1 471 ? 122.339 119.603 110.585 1.00 171.76 ? 471 PHE A CZ  1 
ATOM   3210 N N   . ILE A 1 472 ? 119.896 116.578 116.877 1.00 64.86  ? 472 ILE A N   1 
ATOM   3211 C CA  . ILE A 1 472 ? 119.546 116.215 118.242 1.00 69.18  ? 472 ILE A CA  1 
ATOM   3212 C C   . ILE A 1 472 ? 120.570 115.190 118.714 1.00 88.57  ? 472 ILE A C   1 
ATOM   3213 O O   . ILE A 1 472 ? 121.148 115.334 119.793 1.00 107.78 ? 472 ILE A O   1 
ATOM   3214 C CB  . ILE A 1 472 ? 118.103 115.669 118.359 1.00 84.96  ? 472 ILE A CB  1 
ATOM   3215 C CG1 . ILE A 1 472 ? 117.032 116.678 117.962 1.00 122.75 ? 472 ILE A CG1 1 
ATOM   3216 C CG2 . ILE A 1 472 ? 117.820 115.140 119.754 1.00 83.67  ? 472 ILE A CG2 1 
ATOM   3217 C CD1 . ILE A 1 472 ? 115.646 116.053 117.814 1.00 139.32 ? 472 ILE A CD1 1 
ATOM   3218 N N   . GLN A 1 473 ? 120.800 114.144 117.899 1.00 100.06 ? 473 GLN A N   1 
ATOM   3219 C CA  . GLN A 1 473 ? 121.672 113.027 118.234 1.00 89.18  ? 473 GLN A CA  1 
ATOM   3220 C C   . GLN A 1 473 ? 123.107 113.493 118.503 1.00 90.48  ? 473 GLN A C   1 
ATOM   3221 O O   . GLN A 1 473 ? 123.722 113.062 119.464 1.00 84.01  ? 473 GLN A O   1 
ATOM   3222 C CB  . GLN A 1 473 ? 121.603 112.012 117.097 1.00 86.56  ? 473 GLN A CB  1 
ATOM   3223 C CG  . GLN A 1 473 ? 122.205 110.660 117.428 1.00 88.72  ? 473 GLN A CG  1 
ATOM   3224 C CD  . GLN A 1 473 ? 122.091 109.689 116.268 1.00 106.58 ? 473 GLN A CD  1 
ATOM   3225 O OE1 . GLN A 1 473 ? 121.973 110.062 115.100 1.00 100.58 ? 473 GLN A OE1 1 
ATOM   3226 N NE2 . GLN A 1 473 ? 122.163 108.404 116.572 1.00 132.60 ? 473 GLN A NE2 1 
ATOM   3227 N N   . LYS A 1 474 ? 123.641 114.386 117.663 1.00 109.22 ? 474 LYS A N   1 
ATOM   3228 C CA  . LYS A 1 474 ? 124.985 114.936 117.810 1.00 117.82 ? 474 LYS A CA  1 
ATOM   3229 C C   . LYS A 1 474 ? 125.138 115.774 119.083 1.00 105.79 ? 474 LYS A C   1 
ATOM   3230 O O   . LYS A 1 474 ? 126.248 115.877 119.609 1.00 132.08 ? 474 LYS A O   1 
ATOM   3231 C CB  . LYS A 1 474 ? 125.321 115.765 116.561 1.00 168.22 ? 474 LYS A CB  1 
ATOM   3232 C CG  . LYS A 1 474 ? 126.690 116.438 116.543 1.00 195.58 ? 474 LYS A CG  1 
ATOM   3233 C CD  . LYS A 1 474 ? 126.996 117.132 115.236 1.00 236.05 ? 474 LYS A CD  1 
ATOM   3234 C CE  . LYS A 1 474 ? 128.355 117.802 115.219 1.00 264.93 ? 474 LYS A CE  1 
ATOM   3235 N NZ  . LYS A 1 474 ? 128.734 118.259 113.860 1.00 276.46 ? 474 LYS A NZ  1 
ATOM   3236 N N   . SER A 1 475 ? 124.042 116.391 119.570 1.00 115.07 ? 475 SER A N   1 
ATOM   3237 C CA  . SER A 1 475 ? 124.069 117.340 120.681 1.00 123.85 ? 475 SER A CA  1 
ATOM   3238 C C   . SER A 1 475 ? 123.861 116.679 122.048 1.00 106.30 ? 475 SER A C   1 
ATOM   3239 O O   . SER A 1 475 ? 124.273 117.249 123.055 1.00 113.02 ? 475 SER A O   1 
ATOM   3240 C CB  . SER A 1 475 ? 123.041 118.425 120.477 1.00 160.22 ? 475 SER A CB  1 
ATOM   3241 O OG  . SER A 1 475 ? 123.249 119.098 119.238 1.00 201.56 ? 475 SER A OG  1 
ATOM   3242 N N   . LEU A 1 476 ? 123.209 115.502 122.095 1.00 105.51 ? 476 LEU A N   1 
ATOM   3243 C CA  . LEU A 1 476 ? 122.881 114.824 123.346 1.00 105.98 ? 476 LEU A CA  1 
ATOM   3244 C C   . LEU A 1 476 ? 123.509 113.425 123.451 1.00 115.14 ? 476 LEU A C   1 
ATOM   3245 O O   . LEU A 1 476 ? 123.537 112.864 124.543 1.00 134.96 ? 476 LEU A O   1 
ATOM   3246 C CB  . LEU A 1 476 ? 121.353 114.717 123.456 1.00 100.42 ? 476 LEU A CB  1 
ATOM   3247 C CG  . LEU A 1 476 ? 120.601 116.039 123.554 1.00 107.79 ? 476 LEU A CG  1 
ATOM   3248 C CD1 . LEU A 1 476 ? 119.106 115.808 123.511 1.00 113.92 ? 476 LEU A CD1 1 
ATOM   3249 C CD2 . LEU A 1 476 ? 120.970 116.779 124.826 1.00 143.85 ? 476 LEU A CD2 1 
ATOM   3250 N N   . ASP A 1 477 ? 123.972 112.851 122.334 1.00 117.79 ? 477 ASP A N   1 
ATOM   3251 C CA  . ASP A 1 477 ? 124.509 111.497 122.260 1.00 144.24 ? 477 ASP A CA  1 
ATOM   3252 C C   . ASP A 1 477 ? 123.491 110.484 122.807 1.00 131.53 ? 477 ASP A C   1 
ATOM   3253 O O   . ASP A 1 477 ? 122.424 110.315 122.228 1.00 132.06 ? 477 ASP A O   1 
ATOM   3254 C CB  . ASP A 1 477 ? 125.924 111.409 122.850 1.00 173.96 ? 477 ASP A CB  1 
ATOM   3255 C CG  . ASP A 1 477 ? 126.809 110.369 122.159 1.00 234.73 ? 477 ASP A CG  1 
ATOM   3256 O OD1 . ASP A 1 477 ? 126.542 110.021 120.965 1.00 261.85 ? 477 ASP A OD1 1 
ATOM   3257 O OD2 . ASP A 1 477 ? 127.750 109.877 122.822 1.00 260.42 ? 477 ASP A OD2 1 
ATOM   3258 N N   . THR A 1 478 ? 123.799 109.766 123.901 1.00 131.79 ? 478 THR A N   1 
ATOM   3259 C CA  . THR A 1 478 ? 122.983 108.634 124.328 1.00 120.90 ? 478 THR A CA  1 
ATOM   3260 C C   . THR A 1 478 ? 121.626 109.080 124.875 1.00 110.77 ? 478 THR A C   1 
ATOM   3261 O O   . THR A 1 478 ? 120.698 108.272 124.913 1.00 138.75 ? 478 THR A O   1 
ATOM   3262 C CB  . THR A 1 478 ? 123.706 107.758 125.362 1.00 132.71 ? 478 THR A CB  1 
ATOM   3263 O OG1 . THR A 1 478 ? 123.871 108.485 126.579 1.00 112.69 ? 478 THR A OG1 1 
ATOM   3264 C CG2 . THR A 1 478 ? 125.056 107.267 124.887 1.00 175.00 ? 478 THR A CG2 1 
ATOM   3265 N N   . TYR A 1 479 ? 121.486 110.350 125.279 1.00 97.68  ? 479 TYR A N   1 
ATOM   3266 C CA  . TYR A 1 479 ? 120.241 110.846 125.851 1.00 96.76  ? 479 TYR A CA  1 
ATOM   3267 C C   . TYR A 1 479 ? 119.280 111.400 124.789 1.00 74.52  ? 479 TYR A C   1 
ATOM   3268 O O   . TYR A 1 479 ? 118.224 111.915 125.140 1.00 79.09  ? 479 TYR A O   1 
ATOM   3269 C CB  . TYR A 1 479 ? 120.529 111.944 126.883 1.00 115.80 ? 479 TYR A CB  1 
ATOM   3270 C CG  . TYR A 1 479 ? 121.416 111.518 128.045 1.00 114.58 ? 479 TYR A CG  1 
ATOM   3271 C CD1 . TYR A 1 479 ? 121.005 110.596 128.983 1.00 106.44 ? 479 TYR A CD1 1 
ATOM   3272 C CD2 . TYR A 1 479 ? 122.698 112.023 128.174 1.00 162.93 ? 479 TYR A CD2 1 
ATOM   3273 C CE1 . TYR A 1 479 ? 121.823 110.222 130.035 1.00 128.11 ? 479 TYR A CE1 1 
ATOM   3274 C CE2 . TYR A 1 479 ? 123.534 111.648 129.213 1.00 172.95 ? 479 TYR A CE2 1 
ATOM   3275 C CZ  . TYR A 1 479 ? 123.100 110.731 130.144 1.00 144.55 ? 479 TYR A CZ  1 
ATOM   3276 O OH  . TYR A 1 479 ? 123.923 110.358 131.170 1.00 158.62 ? 479 TYR A OH  1 
ATOM   3277 N N   . CYS A 1 480 ? 119.574 111.252 123.498 1.00 70.13  ? 480 CYS A N   1 
ATOM   3278 C CA  . CYS A 1 480 ? 118.764 111.857 122.452 1.00 87.45  ? 480 CYS A CA  1 
ATOM   3279 C C   . CYS A 1 480 ? 117.326 111.342 122.462 1.00 90.43  ? 480 CYS A C   1 
ATOM   3280 O O   . CYS A 1 480 ? 116.410 112.058 122.056 1.00 102.36 ? 480 CYS A O   1 
ATOM   3281 C CB  . CYS A 1 480 ? 119.381 111.624 121.073 1.00 117.68 ? 480 CYS A CB  1 
ATOM   3282 S SG  . CYS A 1 480 ? 119.624 109.874 120.665 1.00 121.53 ? 480 CYS A SG  1 
ATOM   3283 N N   . PHE A 1 481 ? 117.092 110.100 122.918 1.00 95.05  ? 481 PHE A N   1 
ATOM   3284 C CA  . PHE A 1 481 ? 115.748 109.539 122.919 1.00 93.59  ? 481 PHE A CA  1 
ATOM   3285 C C   . PHE A 1 481 ? 114.881 110.052 124.080 1.00 82.96  ? 481 PHE A C   1 
ATOM   3286 O O   . PHE A 1 481 ? 113.687 109.773 124.105 1.00 89.15  ? 481 PHE A O   1 
ATOM   3287 C CB  . PHE A 1 481 ? 115.825 108.013 122.890 1.00 88.56  ? 481 PHE A CB  1 
ATOM   3288 C CG  . PHE A 1 481 ? 116.175 107.492 121.525 1.00 90.67  ? 481 PHE A CG  1 
ATOM   3289 C CD1 . PHE A 1 481 ? 115.210 107.388 120.540 1.00 84.27  ? 481 PHE A CD1 1 
ATOM   3290 C CD2 . PHE A 1 481 ? 117.476 107.146 121.216 1.00 97.31  ? 481 PHE A CD2 1 
ATOM   3291 C CE1 . PHE A 1 481 ? 115.528 106.913 119.278 1.00 94.71  ? 481 PHE A CE1 1 
ATOM   3292 C CE2 . PHE A 1 481 ? 117.790 106.672 119.949 1.00 113.14 ? 481 PHE A CE2 1 
ATOM   3293 C CZ  . PHE A 1 481 ? 116.813 106.558 118.983 1.00 95.13  ? 481 PHE A CZ  1 
ATOM   3294 N N   . LEU A 1 482 ? 115.417 110.851 125.006 1.00 74.19  ? 482 LEU A N   1 
ATOM   3295 C CA  . LEU A 1 482 ? 114.562 111.455 126.016 1.00 77.92  ? 482 LEU A CA  1 
ATOM   3296 C C   . LEU A 1 482 ? 113.648 112.526 125.402 1.00 87.99  ? 482 LEU A C   1 
ATOM   3297 O O   . LEU A 1 482 ? 112.643 112.881 126.022 1.00 113.15 ? 482 LEU A O   1 
ATOM   3298 C CB  . LEU A 1 482 ? 115.418 112.040 127.148 1.00 92.25  ? 482 LEU A CB  1 
ATOM   3299 C CG  . LEU A 1 482 ? 116.177 111.015 127.980 1.00 94.68  ? 482 LEU A CG  1 
ATOM   3300 C CD1 . LEU A 1 482 ? 116.953 111.663 129.110 1.00 121.12 ? 482 LEU A CD1 1 
ATOM   3301 C CD2 . LEU A 1 482 ? 115.237 109.965 128.544 1.00 99.88  ? 482 LEU A CD2 1 
ATOM   3302 N N   . VAL A 1 483 ? 113.959 113.039 124.199 1.00 79.37  ? 483 VAL A N   1 
ATOM   3303 C CA  . VAL A 1 483 ? 113.086 113.977 123.505 1.00 80.88  ? 483 VAL A CA  1 
ATOM   3304 C C   . VAL A 1 483 ? 111.806 113.262 123.066 1.00 81.55  ? 483 VAL A C   1 
ATOM   3305 O O   . VAL A 1 483 ? 110.709 113.735 123.365 1.00 87.62  ? 483 VAL A O   1 
ATOM   3306 C CB  . VAL A 1 483 ? 113.806 114.651 122.328 1.00 90.42  ? 483 VAL A CB  1 
ATOM   3307 C CG1 . VAL A 1 483 ? 112.876 115.470 121.449 1.00 111.10 ? 483 VAL A CG1 1 
ATOM   3308 C CG2 . VAL A 1 483 ? 114.975 115.499 122.823 1.00 97.05  ? 483 VAL A CG2 1 
ATOM   3309 N N   . PHE A 1 484 ? 111.935 112.098 122.410 1.00 79.22  ? 484 PHE A N   1 
ATOM   3310 C CA  . PHE A 1 484 ? 110.779 111.329 121.977 1.00 77.09  ? 484 PHE A CA  1 
ATOM   3311 C C   . PHE A 1 484 ? 110.023 110.728 123.168 1.00 79.15  ? 484 PHE A C   1 
ATOM   3312 O O   . PHE A 1 484 ? 108.807 110.563 123.093 1.00 96.94  ? 484 PHE A O   1 
ATOM   3313 C CB  . PHE A 1 484 ? 111.212 110.268 120.969 1.00 77.40  ? 484 PHE A CB  1 
ATOM   3314 C CG  . PHE A 1 484 ? 111.927 110.773 119.740 1.00 98.77  ? 484 PHE A CG  1 
ATOM   3315 C CD1 . PHE A 1 484 ? 111.753 112.066 119.276 1.00 126.43 ? 484 PHE A CD1 1 
ATOM   3316 C CD2 . PHE A 1 484 ? 112.797 109.957 119.046 1.00 113.10 ? 484 PHE A CD2 1 
ATOM   3317 C CE1 . PHE A 1 484 ? 112.416 112.520 118.144 1.00 131.65 ? 484 PHE A CE1 1 
ATOM   3318 C CE2 . PHE A 1 484 ? 113.450 110.410 117.915 1.00 117.64 ? 484 PHE A CE2 1 
ATOM   3319 C CZ  . PHE A 1 484 ? 113.265 111.690 117.467 1.00 110.18 ? 484 PHE A CZ  1 
ATOM   3320 N N   . ALA A 1 485 ? 110.711 110.437 124.282 1.00 90.64  ? 485 ALA A N   1 
ATOM   3321 C CA  . ALA A 1 485 ? 110.051 110.056 125.526 1.00 89.18  ? 485 ALA A CA  1 
ATOM   3322 C C   . ALA A 1 485 ? 109.184 111.192 126.062 1.00 82.54  ? 485 ALA A C   1 
ATOM   3323 O O   . ALA A 1 485 ? 108.077 110.937 126.534 1.00 108.51 ? 485 ALA A O   1 
ATOM   3324 C CB  . ALA A 1 485 ? 111.077 109.648 126.558 1.00 122.09 ? 485 ALA A CB  1 
ATOM   3325 N N   . THR A 1 486 ? 109.678 112.439 126.015 1.00 83.37  ? 486 THR A N   1 
ATOM   3326 C CA  . THR A 1 486 ? 108.963 113.597 126.540 1.00 98.54  ? 486 THR A CA  1 
ATOM   3327 C C   . THR A 1 486 ? 107.742 113.937 125.687 1.00 84.89  ? 486 THR A C   1 
ATOM   3328 O O   . THR A 1 486 ? 106.710 114.319 126.229 1.00 116.81 ? 486 THR A O   1 
ATOM   3329 C CB  . THR A 1 486 ? 109.889 114.816 126.658 1.00 121.50 ? 486 THR A CB  1 
ATOM   3330 O OG1 . THR A 1 486 ? 110.918 114.478 127.595 1.00 165.80 ? 486 THR A OG1 1 
ATOM   3331 C CG2 . THR A 1 486 ? 109.190 116.082 127.110 1.00 123.71 ? 486 THR A CG2 1 
ATOM   3332 N N   . ILE A 1 487 ? 107.847 113.786 124.362 1.00 73.48  ? 487 ILE A N   1 
ATOM   3333 C CA  . ILE A 1 487 ? 106.737 114.071 123.465 1.00 75.86  ? 487 ILE A CA  1 
ATOM   3334 C C   . ILE A 1 487 ? 105.681 112.961 123.517 1.00 75.62  ? 487 ILE A C   1 
ATOM   3335 O O   . ILE A 1 487 ? 104.500 113.281 123.616 1.00 95.64  ? 487 ILE A O   1 
ATOM   3336 C CB  . ILE A 1 487 ? 107.244 114.357 122.040 1.00 84.84  ? 487 ILE A CB  1 
ATOM   3337 C CG1 . ILE A 1 487 ? 107.942 115.724 122.032 1.00 113.21 ? 487 ILE A CG1 1 
ATOM   3338 C CG2 . ILE A 1 487 ? 106.133 114.256 121.003 1.00 72.85  ? 487 ILE A CG2 1 
ATOM   3339 C CD1 . ILE A 1 487 ? 108.620 116.093 120.726 1.00 127.66 ? 487 ILE A CD1 1 
ATOM   3340 N N   . CYS A 1 488 ? 106.065 111.678 123.512 1.00 76.07  ? 488 CYS A N   1 
ATOM   3341 C CA  . CYS A 1 488 ? 105.088 110.608 123.632 1.00 68.44  ? 488 CYS A CA  1 
ATOM   3342 C C   . CYS A 1 488 ? 104.295 110.724 124.926 1.00 69.25  ? 488 CYS A C   1 
ATOM   3343 O O   . CYS A 1 488 ? 103.074 110.710 124.883 1.00 97.21  ? 488 CYS A O   1 
ATOM   3344 C CB  . CYS A 1 488 ? 105.758 109.241 123.551 1.00 87.81  ? 488 CYS A CB  1 
ATOM   3345 S SG  . CYS A 1 488 ? 106.383 108.891 121.887 1.00 99.06  ? 488 CYS A SG  1 
ATOM   3346 N N   . ILE A 1 489 ? 104.952 110.872 126.091 1.00 73.58  ? 489 ILE A N   1 
ATOM   3347 C CA  . ILE A 1 489 ? 104.227 110.940 127.356 1.00 72.38  ? 489 ILE A CA  1 
ATOM   3348 C C   . ILE A 1 489 ? 103.382 112.214 127.447 1.00 79.37  ? 489 ILE A C   1 
ATOM   3349 O O   . ILE A 1 489 ? 102.304 112.168 128.029 1.00 89.32  ? 489 ILE A O   1 
ATOM   3350 C CB  . ILE A 1 489 ? 105.176 110.736 128.542 1.00 88.59  ? 489 ILE A CB  1 
ATOM   3351 C CG1 . ILE A 1 489 ? 105.599 109.268 128.616 1.00 103.63 ? 489 ILE A CG1 1 
ATOM   3352 C CG2 . ILE A 1 489 ? 104.569 111.225 129.858 1.00 106.78 ? 489 ILE A CG2 1 
ATOM   3353 C CD1 . ILE A 1 489 ? 106.795 109.038 129.547 1.00 142.54 ? 489 ILE A CD1 1 
ATOM   3354 N N   . THR A 1 490 ? 103.788 113.325 126.810 1.00 81.26  ? 490 THR A N   1 
ATOM   3355 C CA  . THR A 1 490 ? 102.942 114.515 126.743 1.00 80.21  ? 490 THR A CA  1 
ATOM   3356 C C   . THR A 1 490 ? 101.702 114.266 125.873 1.00 89.76  ? 490 THR A C   1 
ATOM   3357 O O   . THR A 1 490 ? 100.619 114.743 126.207 1.00 126.69 ? 490 THR A O   1 
ATOM   3358 C CB  . THR A 1 490 ? 103.716 115.737 126.259 1.00 93.63  ? 490 THR A CB  1 
ATOM   3359 O OG1 . THR A 1 490 ? 104.725 115.999 127.234 1.00 116.47 ? 490 THR A OG1 1 
ATOM   3360 C CG2 . THR A 1 490 ? 102.856 116.971 126.093 1.00 122.39 ? 490 THR A CG2 1 
ATOM   3361 N N   . GLY A 1 491 ? 101.841 113.508 124.781 1.00 80.88  ? 491 GLY A N   1 
ATOM   3362 C CA  . GLY A 1 491 ? 100.700 113.068 123.989 1.00 84.10  ? 491 GLY A CA  1 
ATOM   3363 C C   . GLY A 1 491 ? 99.737  112.190 124.797 1.00 78.46  ? 491 GLY A C   1 
ATOM   3364 O O   . GLY A 1 491 ? 98.535  112.387 124.739 1.00 77.30  ? 491 GLY A O   1 
ATOM   3365 N N   . ALA A 1 492 ? 100.264 111.223 125.563 1.00 65.50  ? 492 ALA A N   1 
ATOM   3366 C CA  . ALA A 1 492 ? 99.451  110.301 126.325 1.00 73.85  ? 492 ALA A CA  1 
ATOM   3367 C C   . ALA A 1 492 ? 98.773  110.982 127.514 1.00 84.63  ? 492 ALA A C   1 
ATOM   3368 O O   . ALA A 1 492 ? 97.624  110.648 127.820 1.00 141.11 ? 492 ALA A O   1 
ATOM   3369 C CB  . ALA A 1 492 ? 100.277 109.122 126.774 1.00 92.63  ? 492 ALA A CB  1 
ATOM   3370 N N   . ILE A 1 493 ? 99.434  111.921 128.199 1.00 71.10  ? 493 ILE A N   1 
ATOM   3371 C CA  . ILE A 1 493 ? 98.793  112.639 129.297 1.00 80.37  ? 493 ILE A CA  1 
ATOM   3372 C C   . ILE A 1 493 ? 97.700  113.563 128.748 1.00 80.84  ? 493 ILE A C   1 
ATOM   3373 O O   . ILE A 1 493 ? 96.617  113.661 129.343 1.00 96.09  ? 493 ILE A O   1 
ATOM   3374 C CB  . ILE A 1 493 ? 99.794  113.384 130.196 1.00 90.15  ? 493 ILE A CB  1 
ATOM   3375 C CG1 . ILE A 1 493 ? 100.714 112.446 130.964 1.00 114.39 ? 493 ILE A CG1 1 
ATOM   3376 C CG2 . ILE A 1 493 ? 99.061  114.258 131.186 1.00 94.47  ? 493 ILE A CG2 1 
ATOM   3377 C CD1 . ILE A 1 493 ? 101.904 113.159 131.620 1.00 106.54 ? 493 ILE A CD1 1 
ATOM   3378 N N   . TYR A 1 494 ? 97.935  114.196 127.596 1.00 72.45  ? 494 TYR A N   1 
ATOM   3379 C CA  . TYR A 1 494 ? 96.901  114.998 126.947 1.00 92.28  ? 494 TYR A CA  1 
ATOM   3380 C C   . TYR A 1 494 ? 95.665  114.151 126.601 1.00 91.07  ? 494 TYR A C   1 
ATOM   3381 O O   . TYR A 1 494 ? 94.568  114.461 127.050 1.00 88.82  ? 494 TYR A O   1 
ATOM   3382 C CB  . TYR A 1 494 ? 97.457  115.728 125.712 1.00 106.70 ? 494 TYR A CB  1 
ATOM   3383 C CG  . TYR A 1 494 ? 96.359  116.452 124.944 1.00 74.31  ? 494 TYR A CG  1 
ATOM   3384 C CD1 . TYR A 1 494 ? 95.887  117.676 125.389 1.00 90.26  ? 494 TYR A CD1 1 
ATOM   3385 C CD2 . TYR A 1 494 ? 95.746  115.872 123.857 1.00 52.81  ? 494 TYR A CD2 1 
ATOM   3386 C CE1 . TYR A 1 494 ? 94.841  118.319 124.759 1.00 92.41  ? 494 TYR A CE1 1 
ATOM   3387 C CE2 . TYR A 1 494 ? 94.706  116.497 123.209 1.00 71.68  ? 494 TYR A CE2 1 
ATOM   3388 C CZ  . TYR A 1 494 ? 94.257  117.726 123.659 1.00 101.60 ? 494 TYR A CZ  1 
ATOM   3389 O OH  . TYR A 1 494 ? 93.201  118.343 123.044 1.00 128.65 ? 494 TYR A OH  1 
ATOM   3390 N N   . LEU A 1 495 ? 95.818  113.084 125.803 1.00 84.00  ? 495 LEU A N   1 
ATOM   3391 C CA  . LEU A 1 495 ? 94.669  112.330 125.310 1.00 72.48  ? 495 LEU A CA  1 
ATOM   3392 C C   . LEU A 1 495 ? 93.915  111.673 126.460 1.00 78.29  ? 495 LEU A C   1 
ATOM   3393 O O   . LEU A 1 495 ? 92.696  111.545 126.364 1.00 98.52  ? 495 LEU A O   1 
ATOM   3394 C CB  . LEU A 1 495 ? 95.103  111.313 124.253 1.00 64.04  ? 495 LEU A CB  1 
ATOM   3395 C CG  . LEU A 1 495 ? 95.623  111.892 122.952 1.00 77.46  ? 495 LEU A CG  1 
ATOM   3396 C CD1 . LEU A 1 495 ? 96.131  110.810 122.024 1.00 78.98  ? 495 LEU A CD1 1 
ATOM   3397 C CD2 . LEU A 1 495 ? 94.560  112.700 122.271 1.00 86.00  ? 495 LEU A CD2 1 
ATOM   3398 N N   . TYR A 1 496 ? 94.580  111.326 127.569 1.00 78.43  ? 496 TYR A N   1 
ATOM   3399 C CA  . TYR A 1 496 ? 93.872  110.861 128.757 1.00 93.93  ? 496 TYR A CA  1 
ATOM   3400 C C   . TYR A 1 496 ? 92.882  111.928 129.244 1.00 102.66 ? 496 TYR A C   1 
ATOM   3401 O O   . TYR A 1 496 ? 91.719  111.612 129.502 1.00 114.25 ? 496 TYR A O   1 
ATOM   3402 C CB  . TYR A 1 496 ? 94.848  110.431 129.854 1.00 106.49 ? 496 TYR A CB  1 
ATOM   3403 C CG  . TYR A 1 496 ? 94.122  109.932 131.094 1.00 104.98 ? 496 TYR A CG  1 
ATOM   3404 C CD1 . TYR A 1 496 ? 93.690  108.618 131.201 1.00 105.52 ? 496 TYR A CD1 1 
ATOM   3405 C CD2 . TYR A 1 496 ? 93.796  110.815 132.127 1.00 119.11 ? 496 TYR A CD2 1 
ATOM   3406 C CE1 . TYR A 1 496 ? 93.004  108.185 132.324 1.00 143.02 ? 496 TYR A CE1 1 
ATOM   3407 C CE2 . TYR A 1 496 ? 93.107  110.390 133.251 1.00 127.54 ? 496 TYR A CE2 1 
ATOM   3408 C CZ  . TYR A 1 496 ? 92.699  109.074 133.343 1.00 155.86 ? 496 TYR A CZ  1 
ATOM   3409 O OH  . TYR A 1 496 ? 92.017  108.650 134.452 1.00 195.87 ? 496 TYR A OH  1 
ATOM   3410 N N   . PHE A 1 497 ? 93.303  113.196 129.361 1.00 89.49  ? 497 PHE A N   1 
ATOM   3411 C CA  . PHE A 1 497 ? 92.424  114.234 129.880 1.00 95.16  ? 497 PHE A CA  1 
ATOM   3412 C C   . PHE A 1 497 ? 91.459  114.815 128.835 1.00 102.72 ? 497 PHE A C   1 
ATOM   3413 O O   . PHE A 1 497 ? 90.698  115.708 129.202 1.00 121.48 ? 497 PHE A O   1 
ATOM   3414 C CB  . PHE A 1 497 ? 93.250  115.376 130.483 1.00 119.57 ? 497 PHE A CB  1 
ATOM   3415 C CG  . PHE A 1 497 ? 94.009  115.037 131.746 1.00 131.59 ? 497 PHE A CG  1 
ATOM   3416 C CD1 . PHE A 1 497 ? 93.364  114.423 132.803 1.00 139.52 ? 497 PHE A CD1 1 
ATOM   3417 C CD2 . PHE A 1 497 ? 95.340  115.390 131.898 1.00 152.61 ? 497 PHE A CD2 1 
ATOM   3418 C CE1 . PHE A 1 497 ? 94.041  114.140 133.978 1.00 158.98 ? 497 PHE A CE1 1 
ATOM   3419 C CE2 . PHE A 1 497 ? 96.020  115.087 133.064 1.00 175.23 ? 497 PHE A CE2 1 
ATOM   3420 C CZ  . PHE A 1 497 ? 95.365  114.479 134.106 1.00 176.88 ? 497 PHE A CZ  1 
ATOM   3421 N N   . VAL A 1 498 ? 91.449  114.347 127.564 1.00 92.68  ? 498 VAL A N   1 
ATOM   3422 C CA  . VAL A 1 498 ? 90.571  114.941 126.550 1.00 79.71  ? 498 VAL A CA  1 
ATOM   3423 C C   . VAL A 1 498 ? 89.766  113.926 125.724 1.00 91.20  ? 498 VAL A C   1 
ATOM   3424 O O   . VAL A 1 498 ? 88.552  114.088 125.634 1.00 107.26 ? 498 VAL A O   1 
ATOM   3425 C CB  . VAL A 1 498 ? 91.337  115.899 125.629 1.00 77.63  ? 498 VAL A CB  1 
ATOM   3426 C CG1 . VAL A 1 498 ? 90.474  116.373 124.463 1.00 89.50  ? 498 VAL A CG1 1 
ATOM   3427 C CG2 . VAL A 1 498 ? 91.879  117.086 126.413 1.00 89.22  ? 498 VAL A CG2 1 
ATOM   3428 N N   . LEU A 1 499 ? 90.400  112.910 125.105 1.00 105.30 ? 499 LEU A N   1 
ATOM   3429 C CA  . LEU A 1 499 ? 89.797  112.133 124.017 1.00 92.89  ? 499 LEU A CA  1 
ATOM   3430 C C   . LEU A 1 499 ? 88.624  111.273 124.515 1.00 107.02 ? 499 LEU A C   1 
ATOM   3431 O O   . LEU A 1 499 ? 88.828  110.302 125.258 1.00 104.91 ? 499 LEU A O   1 
ATOM   3432 C CB  . LEU A 1 499 ? 90.894  111.240 123.424 1.00 85.56  ? 499 LEU A CB  1 
ATOM   3433 C CG  . LEU A 1 499 ? 90.484  110.235 122.353 1.00 88.63  ? 499 LEU A CG  1 
ATOM   3434 C CD1 . LEU A 1 499 ? 90.094  110.959 121.084 1.00 97.03  ? 499 LEU A CD1 1 
ATOM   3435 C CD2 . LEU A 1 499 ? 91.574  109.214 122.072 1.00 96.85  ? 499 LEU A CD2 1 
ATOM   3436 N N   . PRO A 1 500 ? 87.359  111.546 124.077 1.00 112.32 ? 500 PRO A N   1 
ATOM   3437 C CA  . PRO A 1 500 ? 86.232  110.677 124.412 1.00 121.69 ? 500 PRO A CA  1 
ATOM   3438 C C   . PRO A 1 500 ? 86.207  109.455 123.498 1.00 120.18 ? 500 PRO A C   1 
ATOM   3439 O O   . PRO A 1 500 ? 86.579  109.552 122.329 1.00 101.30 ? 500 PRO A O   1 
ATOM   3440 C CB  . PRO A 1 500 ? 85.019  111.587 124.185 1.00 137.67 ? 500 PRO A CB  1 
ATOM   3441 C CG  . PRO A 1 500 ? 85.459  112.508 123.058 1.00 137.15 ? 500 PRO A CG  1 
ATOM   3442 C CD  . PRO A 1 500 ? 86.953  112.688 123.231 1.00 117.79 ? 500 PRO A CD  1 
ATOM   3443 N N   . GLU A 1 501 ? 85.750  108.312 124.045 1.00 136.24 ? 501 GLU A N   1 
ATOM   3444 C CA  . GLU A 1 501 ? 85.747  107.039 123.327 1.00 143.99 ? 501 GLU A CA  1 
ATOM   3445 C C   . GLU A 1 501 ? 84.883  107.155 122.064 1.00 127.99 ? 501 GLU A C   1 
ATOM   3446 O O   . GLU A 1 501 ? 83.923  107.928 122.026 1.00 109.01 ? 501 GLU A O   1 
ATOM   3447 C CB  . GLU A 1 501 ? 85.297  105.915 124.261 1.00 148.06 ? 501 GLU A CB  1 
ATOM   3448 C CG  . GLU A 1 501 ? 85.315  104.533 123.621 1.00 190.81 ? 501 GLU A CG  1 
ATOM   3449 C CD  . GLU A 1 501 ? 86.578  104.173 122.849 1.00 193.21 ? 501 GLU A CD  1 
ATOM   3450 O OE1 . GLU A 1 501 ? 87.654  104.128 123.463 1.00 196.50 ? 501 GLU A OE1 1 
ATOM   3451 O OE2 . GLU A 1 501 ? 86.485  103.948 121.629 1.00 181.92 ? 501 GLU A OE2 1 
ATOM   3452 N N   . THR A 1 502 ? 85.229  106.366 121.027 1.00 120.14 ? 502 THR A N   1 
ATOM   3453 C CA  . THR A 1 502 ? 84.694  106.555 119.685 1.00 106.87 ? 502 THR A CA  1 
ATOM   3454 C C   . THR A 1 502 ? 84.080  105.270 119.111 1.00 123.93 ? 502 THR A C   1 
ATOM   3455 O O   . THR A 1 502 ? 83.242  105.353 118.213 1.00 156.06 ? 502 THR A O   1 
ATOM   3456 C CB  . THR A 1 502 ? 85.781  107.088 118.740 1.00 114.02 ? 502 THR A CB  1 
ATOM   3457 O OG1 . THR A 1 502 ? 86.745  107.858 119.465 1.00 106.24 ? 502 THR A OG1 1 
ATOM   3458 C CG2 . THR A 1 502 ? 85.212  107.931 117.616 1.00 114.55 ? 502 THR A CG2 1 
ATOM   3459 N N   . LYS A 1 503 ? 84.467  104.090 119.623 1.00 144.52 ? 503 LYS A N   1 
ATOM   3460 C CA  . LYS A 1 503 ? 83.941  102.816 119.145 1.00 172.58 ? 503 LYS A CA  1 
ATOM   3461 C C   . LYS A 1 503 ? 82.480  102.646 119.587 1.00 176.26 ? 503 LYS A C   1 
ATOM   3462 O O   . LYS A 1 503 ? 82.165  102.803 120.768 1.00 153.03 ? 503 LYS A O   1 
ATOM   3463 C CB  . LYS A 1 503 ? 84.823  101.673 119.665 1.00 193.24 ? 503 LYS A CB  1 
ATOM   3464 C CG  . LYS A 1 503 ? 84.520  100.286 119.106 1.00 223.63 ? 503 LYS A CG  1 
ATOM   3465 C CD  . LYS A 1 503 ? 84.894  100.106 117.647 1.00 231.55 ? 503 LYS A CD  1 
ATOM   3466 C CE  . LYS A 1 503 ? 84.684  98.696  117.128 1.00 244.05 ? 503 LYS A CE  1 
ATOM   3467 N NZ  . LYS A 1 503 ? 83.305  98.472  116.635 1.00 247.89 ? 503 LYS A NZ  1 
ATOM   3468 N N   . ASN A 1 504 ? 81.600  102.329 118.614 1.00 169.49 ? 504 ASN A N   1 
ATOM   3469 C CA  . ASN A 1 504 ? 80.169  102.115 118.806 1.00 163.70 ? 504 ASN A CA  1 
ATOM   3470 C C   . ASN A 1 504 ? 79.477  103.356 119.390 1.00 161.57 ? 504 ASN A C   1 
ATOM   3471 O O   . ASN A 1 504 ? 78.439  103.225 120.046 1.00 178.83 ? 504 ASN A O   1 
ATOM   3472 C CB  . ASN A 1 504 ? 79.878  100.854 119.640 1.00 185.24 ? 504 ASN A CB  1 
ATOM   3473 C CG  . ASN A 1 504 ? 80.286  99.553  118.970 1.00 204.46 ? 504 ASN A CG  1 
ATOM   3474 O OD1 . ASN A 1 504 ? 81.028  99.554  117.989 1.00 190.86 ? 504 ASN A OD1 1 
ATOM   3475 N ND2 . ASN A 1 504 ? 79.813  98.435  119.503 1.00 216.06 ? 504 ASN A ND2 1 
ATOM   3476 N N   . ARG A 1 505 ? 80.021  104.562 119.125 1.00 157.10 ? 505 ARG A N   1 
ATOM   3477 C CA  . ARG A 1 505 ? 79.387  105.818 119.520 1.00 157.20 ? 505 ARG A CA  1 
ATOM   3478 C C   . ARG A 1 505 ? 79.014  106.608 118.255 1.00 151.44 ? 505 ARG A C   1 
ATOM   3479 O O   . ARG A 1 505 ? 79.769  106.630 117.280 1.00 140.24 ? 505 ARG A O   1 
ATOM   3480 C CB  . ARG A 1 505 ? 80.281  106.680 120.431 1.00 145.97 ? 505 ARG A CB  1 
ATOM   3481 C CG  . ARG A 1 505 ? 81.102  105.956 121.494 1.00 152.98 ? 505 ARG A CG  1 
ATOM   3482 C CD  . ARG A 1 505 ? 80.347  105.044 122.444 1.00 162.93 ? 505 ARG A CD  1 
ATOM   3483 N NE  . ARG A 1 505 ? 79.486  105.782 123.356 1.00 185.68 ? 505 ARG A NE  1 
ATOM   3484 C CZ  . ARG A 1 505 ? 78.156  105.798 123.305 1.00 230.65 ? 505 ARG A CZ  1 
ATOM   3485 N NH1 . ARG A 1 505 ? 77.482  106.587 124.125 1.00 245.58 ? 505 ARG A NH1 1 
ATOM   3486 N NH2 . ARG A 1 505 ? 77.495  105.068 122.419 1.00 249.95 ? 505 ARG A NH2 1 
ATOM   3487 N N   . THR A 1 506 ? 77.849  107.276 118.284 1.00 156.54 ? 506 THR A N   1 
ATOM   3488 C CA  . THR A 1 506 ? 77.383  108.086 117.165 1.00 180.97 ? 506 THR A CA  1 
ATOM   3489 C C   . THR A 1 506 ? 78.050  109.463 117.163 1.00 154.47 ? 506 THR A C   1 
ATOM   3490 O O   . THR A 1 506 ? 78.521  109.927 118.199 1.00 130.55 ? 506 THR A O   1 
ATOM   3491 C CB  . THR A 1 506 ? 75.863  108.301 117.210 1.00 226.86 ? 506 THR A CB  1 
ATOM   3492 O OG1 . THR A 1 506 ? 75.532  109.017 118.402 1.00 201.57 ? 506 THR A OG1 1 
ATOM   3493 C CG2 . THR A 1 506 ? 75.069  107.013 117.148 1.00 258.09 ? 506 THR A CG2 1 
ATOM   3494 N N   . TYR A 1 507 ? 77.995  110.148 116.006 1.00 139.58 ? 507 TYR A N   1 
ATOM   3495 C CA  . TYR A 1 507 ? 78.448  111.528 115.886 1.00 144.07 ? 507 TYR A CA  1 
ATOM   3496 C C   . TYR A 1 507 ? 77.720  112.432 116.896 1.00 125.46 ? 507 TYR A C   1 
ATOM   3497 O O   . TYR A 1 507 ? 78.308  113.356 117.466 1.00 123.16 ? 507 TYR A O   1 
ATOM   3498 C CB  . TYR A 1 507 ? 78.311  112.042 114.444 1.00 149.75 ? 507 TYR A CB  1 
ATOM   3499 C CG  . TYR A 1 507 ? 78.499  113.550 114.403 1.00 155.69 ? 507 TYR A CG  1 
ATOM   3500 C CD1 . TYR A 1 507 ? 79.765  114.125 114.500 1.00 179.67 ? 507 TYR A CD1 1 
ATOM   3501 C CD2 . TYR A 1 507 ? 77.404  114.402 114.413 1.00 169.87 ? 507 TYR A CD2 1 
ATOM   3502 C CE1 . TYR A 1 507 ? 79.933  115.499 114.534 1.00 183.17 ? 507 TYR A CE1 1 
ATOM   3503 C CE2 . TYR A 1 507 ? 77.565  115.778 114.439 1.00 201.54 ? 507 TYR A CE2 1 
ATOM   3504 C CZ  . TYR A 1 507 ? 78.832  116.329 114.516 1.00 206.24 ? 507 TYR A CZ  1 
ATOM   3505 O OH  . TYR A 1 507 ? 79.023  117.680 114.564 1.00 239.08 ? 507 TYR A OH  1 
ATOM   3506 N N   . ALA A 1 508 ? 76.438  112.147 117.143 1.00 133.23 ? 508 ALA A N   1 
ATOM   3507 C CA  . ALA A 1 508 ? 75.616  112.913 118.073 1.00 164.52 ? 508 ALA A CA  1 
ATOM   3508 C C   . ALA A 1 508 ? 76.121  112.803 119.515 1.00 157.89 ? 508 ALA A C   1 
ATOM   3509 O O   . ALA A 1 508 ? 75.996  113.763 120.279 1.00 137.28 ? 508 ALA A O   1 
ATOM   3510 C CB  . ALA A 1 508 ? 74.176  112.461 117.955 1.00 182.61 ? 508 ALA A CB  1 
ATOM   3511 N N   . GLU A 1 509 ? 76.676  111.639 119.893 1.00 165.84 ? 509 GLU A N   1 
ATOM   3512 C CA  . GLU A 1 509 ? 77.178  111.403 121.242 1.00 185.77 ? 509 GLU A CA  1 
ATOM   3513 C C   . GLU A 1 509 ? 78.577  112.003 121.423 1.00 146.28 ? 509 GLU A C   1 
ATOM   3514 O O   . GLU A 1 509 ? 78.854  112.616 122.455 1.00 112.98 ? 509 GLU A O   1 
ATOM   3515 C CB  . GLU A 1 509 ? 77.166  109.901 121.542 1.00 214.16 ? 509 GLU A CB  1 
ATOM   3516 C CG  . GLU A 1 509 ? 75.767  109.328 121.705 1.00 233.58 ? 509 GLU A CG  1 
ATOM   3517 C CD  . GLU A 1 509 ? 75.665  107.829 121.482 1.00 229.76 ? 509 GLU A CD  1 
ATOM   3518 O OE1 . GLU A 1 509 ? 75.940  107.385 120.352 1.00 170.76 ? 509 GLU A OE1 1 
ATOM   3519 O OE2 . GLU A 1 509 ? 75.323  107.107 122.437 1.00 277.29 ? 509 GLU A OE2 1 
ATOM   3520 N N   . ILE A 1 510 ? 79.458  111.829 120.421 1.00 116.01 ? 510 ILE A N   1 
ATOM   3521 C CA  . ILE A 1 510 ? 80.827  112.325 120.472 1.00 84.26  ? 510 ILE A CA  1 
ATOM   3522 C C   . ILE A 1 510 ? 80.811  113.845 120.595 1.00 92.43  ? 510 ILE A C   1 
ATOM   3523 O O   . ILE A 1 510 ? 81.502  114.406 121.446 1.00 95.62  ? 510 ILE A O   1 
ATOM   3524 C CB  . ILE A 1 510 ? 81.638  111.851 119.245 1.00 80.75  ? 510 ILE A CB  1 
ATOM   3525 C CG1 . ILE A 1 510 ? 81.787  110.334 119.222 1.00 98.95  ? 510 ILE A CG1 1 
ATOM   3526 C CG2 . ILE A 1 510 ? 82.999  112.517 119.190 1.00 91.71  ? 510 ILE A CG2 1 
ATOM   3527 C CD1 . ILE A 1 510 ? 82.084  109.754 117.864 1.00 103.90 ? 510 ILE A CD1 1 
ATOM   3528 N N   . SER A 1 511 ? 80.061  114.526 119.714 1.00 127.92 ? 511 SER A N   1 
ATOM   3529 C CA  . SER A 1 511 ? 80.009  115.983 119.698 1.00 148.15 ? 511 SER A CA  1 
ATOM   3530 C C   . SER A 1 511 ? 79.440  116.535 121.011 1.00 130.83 ? 511 SER A C   1 
ATOM   3531 O O   . SER A 1 511 ? 79.862  117.597 121.466 1.00 102.23 ? 511 SER A O   1 
ATOM   3532 C CB  . SER A 1 511 ? 79.269  116.495 118.468 1.00 142.98 ? 511 SER A CB  1 
ATOM   3533 O OG  . SER A 1 511 ? 77.964  115.947 118.380 1.00 146.65 ? 511 SER A OG  1 
ATOM   3534 N N   . GLN A 1 512 ? 78.505  115.807 121.642 1.00 146.93 ? 512 GLN A N   1 
ATOM   3535 C CA  . GLN A 1 512 ? 77.945  116.200 122.929 1.00 173.09 ? 512 GLN A CA  1 
ATOM   3536 C C   . GLN A 1 512 ? 79.029  116.172 124.014 1.00 161.51 ? 512 GLN A C   1 
ATOM   3537 O O   . GLN A 1 512 ? 79.092  117.085 124.835 1.00 147.93 ? 512 GLN A O   1 
ATOM   3538 C CB  . GLN A 1 512 ? 76.734  115.319 123.269 1.00 204.50 ? 512 GLN A CB  1 
ATOM   3539 C CG  . GLN A 1 512 ? 75.856  115.843 124.406 1.00 243.41 ? 512 GLN A CG  1 
ATOM   3540 C CD  . GLN A 1 512 ? 76.347  115.496 125.793 1.00 266.33 ? 512 GLN A CD  1 
ATOM   3541 O OE1 . GLN A 1 512 ? 76.437  116.351 126.674 1.00 263.20 ? 512 GLN A OE1 1 
ATOM   3542 N NE2 . GLN A 1 512 ? 76.636  114.223 126.009 1.00 279.31 ? 512 GLN A NE2 1 
ATOM   3543 N N   . ALA A 1 513 ? 79.916  115.164 124.000 1.00 161.53 ? 513 ALA A N   1 
ATOM   3544 C CA  . ALA A 1 513 ? 81.001  115.058 124.969 1.00 173.43 ? 513 ALA A CA  1 
ATOM   3545 C C   . ALA A 1 513 ? 81.981  116.232 124.867 1.00 151.74 ? 513 ALA A C   1 
ATOM   3546 O O   . ALA A 1 513 ? 82.392  116.771 125.893 1.00 166.66 ? 513 ALA A O   1 
ATOM   3547 C CB  . ALA A 1 513 ? 81.707  113.730 124.814 1.00 184.58 ? 513 ALA A CB  1 
ATOM   3548 N N   . PHE A 1 514 ? 82.358  116.633 123.645 1.00 134.19 ? 514 PHE A N   1 
ATOM   3549 C CA  . PHE A 1 514 ? 83.225  117.785 123.435 1.00 127.28 ? 514 PHE A CA  1 
ATOM   3550 C C   . PHE A 1 514 ? 82.545  119.114 123.792 1.00 148.15 ? 514 PHE A C   1 
ATOM   3551 O O   . PHE A 1 514 ? 83.248  120.071 124.119 1.00 147.00 ? 514 PHE A O   1 
ATOM   3552 C CB  . PHE A 1 514 ? 83.723  117.824 121.988 1.00 113.30 ? 514 PHE A CB  1 
ATOM   3553 C CG  . PHE A 1 514 ? 84.916  116.950 121.711 1.00 109.14 ? 514 PHE A CG  1 
ATOM   3554 C CD1 . PHE A 1 514 ? 86.165  117.292 122.195 1.00 98.55  ? 514 PHE A CD1 1 
ATOM   3555 C CD2 . PHE A 1 514 ? 84.794  115.823 120.914 1.00 112.97 ? 514 PHE A CD2 1 
ATOM   3556 C CE1 . PHE A 1 514 ? 87.269  116.488 121.942 1.00 107.21 ? 514 PHE A CE1 1 
ATOM   3557 C CE2 . PHE A 1 514 ? 85.900  115.033 120.649 1.00 115.50 ? 514 PHE A CE2 1 
ATOM   3558 C CZ  . PHE A 1 514 ? 87.135  115.373 121.153 1.00 120.05 ? 514 PHE A CZ  1 
ATOM   3559 N N   . SER A 1 515 ? 81.204  119.197 123.736 1.00 160.26 ? 515 SER A N   1 
ATOM   3560 C CA  . SER A 1 515 ? 80.501  120.450 123.992 1.00 167.92 ? 515 SER A CA  1 
ATOM   3561 C C   . SER A 1 515 ? 80.826  121.002 125.387 1.00 179.93 ? 515 SER A C   1 
ATOM   3562 O O   . SER A 1 515 ? 80.817  122.220 125.580 1.00 172.18 ? 515 SER A O   1 
ATOM   3563 C CB  . SER A 1 515 ? 79.000  120.323 123.765 1.00 181.44 ? 515 SER A CB  1 
ATOM   3564 O OG  . SER A 1 515 ? 78.343  119.650 124.835 1.00 193.26 ? 515 SER A OG  1 
ATOM   3565 N N   . LYS A 1 516 ? 81.162  120.122 126.342 1.00 185.73 ? 516 LYS A N   1 
ATOM   3566 C CA  . LYS A 1 516 ? 81.484  120.510 127.711 1.00 197.99 ? 516 LYS A CA  1 
ATOM   3567 C C   . LYS A 1 516 ? 82.737  121.390 127.787 1.00 204.27 ? 516 LYS A C   1 
ATOM   3568 O O   . LYS A 1 516 ? 82.929  122.073 128.798 1.00 233.29 ? 516 LYS A O   1 
ATOM   3569 C CB  . LYS A 1 516 ? 81.682  119.264 128.585 1.00 218.74 ? 516 LYS A CB  1 
ATOM   3570 C CG  . LYS A 1 516 ? 80.513  118.285 128.618 1.00 255.79 ? 516 LYS A CG  1 
ATOM   3571 C CD  . LYS A 1 516 ? 79.181  118.920 128.974 1.00 287.60 ? 516 LYS A CD  1 
ATOM   3572 C CE  . LYS A 1 516 ? 78.046  117.921 129.071 1.00 310.69 ? 516 LYS A CE  1 
ATOM   3573 N NZ  . LYS A 1 516 ? 78.137  117.093 130.298 1.00 319.45 ? 516 LYS A NZ  1 
ATOM   3574 N N   . ARG A 1 517 ? 83.596  121.360 126.744 1.00 189.24 ? 517 ARG A N   1 
ATOM   3575 C CA  . ARG A 1 517 ? 84.839  122.135 126.715 1.00 177.20 ? 517 ARG A CA  1 
ATOM   3576 C C   . ARG A 1 517 ? 84.907  123.107 125.523 1.00 145.36 ? 517 ARG A C   1 
ATOM   3577 O O   . ARG A 1 517 ? 85.596  124.121 125.611 1.00 168.03 ? 517 ARG A O   1 
ATOM   3578 C CB  . ARG A 1 517 ? 86.066  121.211 126.806 1.00 176.59 ? 517 ARG A CB  1 
ATOM   3579 C CG  . ARG A 1 517 ? 86.121  120.057 125.809 1.00 176.80 ? 517 ARG A CG  1 
ATOM   3580 C CD  . ARG A 1 517 ? 87.343  119.182 126.021 1.00 174.02 ? 517 ARG A CD  1 
ATOM   3581 N NE  . ARG A 1 517 ? 87.250  118.383 127.239 1.00 165.16 ? 517 ARG A NE  1 
ATOM   3582 C CZ  . ARG A 1 517 ? 87.901  118.632 128.374 1.00 192.76 ? 517 ARG A CZ  1 
ATOM   3583 N NH1 . ARG A 1 517 ? 87.711  117.856 129.426 1.00 212.67 ? 517 ARG A NH1 1 
ATOM   3584 N NH2 . ARG A 1 517 ? 88.728  119.663 128.471 1.00 199.20 ? 517 ARG A NH2 1 
ATOM   3585 N N   . ASN A 1 518 ? 84.164  122.853 124.438 1.00 139.40 ? 518 ASN A N   1 
ATOM   3586 C CA  . ASN A 1 518 ? 83.940  123.844 123.390 1.00 155.05 ? 518 ASN A CA  1 
ATOM   3587 C C   . ASN A 1 518 ? 83.170  125.058 123.929 1.00 162.87 ? 518 ASN A C   1 
ATOM   3588 O O   . ASN A 1 518 ? 83.399  126.176 123.466 1.00 183.07 ? 518 ASN A O   1 
ATOM   3589 C CB  . ASN A 1 518 ? 83.190  123.231 122.197 1.00 167.80 ? 518 ASN A CB  1 
ATOM   3590 C CG  . ASN A 1 518 ? 84.005  122.276 121.348 1.00 147.31 ? 518 ASN A CG  1 
ATOM   3591 O OD1 . ASN A 1 518 ? 85.219  122.405 121.229 1.00 117.31 ? 518 ASN A OD1 1 
ATOM   3592 N ND2 . ASN A 1 518 ? 83.330  121.340 120.702 1.00 174.92 ? 518 ASN A ND2 1 
ATOM   3593 N N   . LYS A 1 519 ? 82.214  124.818 124.846 1.00 170.92 ? 519 LYS A N   1 
ATOM   3594 C CA  . LYS A 1 519 ? 81.354  125.819 125.479 1.00 201.27 ? 519 LYS A CA  1 
ATOM   3595 C C   . LYS A 1 519 ? 80.480  126.561 124.459 1.00 213.38 ? 519 LYS A C   1 
ATOM   3596 O O   . LYS A 1 519 ? 80.037  127.681 124.721 1.00 210.63 ? 519 LYS A O   1 
ATOM   3597 C CB  . LYS A 1 519 ? 82.180  126.771 126.354 1.00 223.66 ? 519 LYS A CB  1 
ATOM   3598 C CG  . LYS A 1 519 ? 82.853  126.116 127.553 1.00 246.04 ? 519 LYS A CG  1 
ATOM   3599 C CD  . LYS A 1 519 ? 83.638  127.077 128.418 1.00 270.69 ? 519 LYS A CD  1 
ATOM   3600 C CE  . LYS A 1 519 ? 84.314  126.389 129.586 1.00 286.91 ? 519 LYS A CE  1 
ATOM   3601 N NZ  . LYS A 1 519 ? 85.024  127.354 130.459 1.00 290.68 ? 519 LYS A NZ  1 
ATOM   3602 N N   . ALA A 1 520 ? 80.171  125.899 123.330 1.00 223.61 ? 520 ALA A N   1 
ATOM   3603 C CA  . ALA A 1 520 ? 79.356  126.477 122.265 1.00 253.21 ? 520 ALA A CA  1 
ATOM   3604 C C   . ALA A 1 520 ? 78.702  125.369 121.432 1.00 264.86 ? 520 ALA A C   1 
ATOM   3605 O O   . ALA A 1 520 ? 79.139  124.219 121.475 1.00 240.11 ? 520 ALA A O   1 
ATOM   3606 C CB  . ALA A 1 520 ? 80.210  127.383 121.401 1.00 271.41 ? 520 ALA A CB  1 
ATOM   3607 N N   . TYR A 1 521 ? 77.661  125.742 120.663 1.00 291.39 ? 521 TYR A N   1 
ATOM   3608 C CA  . TYR A 1 521 ? 76.888  124.817 119.839 1.00 306.40 ? 521 TYR A CA  1 
ATOM   3609 C C   . TYR A 1 521 ? 76.687  125.386 118.429 1.00 305.58 ? 521 TYR A C   1 
ATOM   3610 O O   . TYR A 1 521 ? 76.741  126.600 118.236 1.00 294.57 ? 521 TYR A O   1 
ATOM   3611 C CB  . TYR A 1 521 ? 75.551  124.537 120.537 1.00 334.66 ? 521 TYR A CB  1 
ATOM   3612 C CG  . TYR A 1 521 ? 75.683  123.762 121.843 1.00 367.69 ? 521 TYR A CG  1 
ATOM   3613 C CD1 . TYR A 1 521 ? 75.781  122.373 121.855 1.00 393.73 ? 521 TYR A CD1 1 
ATOM   3614 C CD2 . TYR A 1 521 ? 75.758  124.424 123.064 1.00 375.57 ? 521 TYR A CD2 1 
ATOM   3615 C CE1 . TYR A 1 521 ? 75.924  121.667 123.039 1.00 403.08 ? 521 TYR A CE1 1 
ATOM   3616 C CE2 . TYR A 1 521 ? 75.896  123.728 124.257 1.00 389.34 ? 521 TYR A CE2 1 
ATOM   3617 C CZ  . TYR A 1 521 ? 75.979  122.346 124.245 1.00 395.61 ? 521 TYR A CZ  1 
ATOM   3618 O OH  . TYR A 1 521 ? 76.119  121.642 125.409 1.00 378.37 ? 521 TYR A OH  1 
ATOM   3619 N N   . PRO A 1 522 ? 76.456  124.526 117.400 1.00 320.57 ? 522 PRO A N   1 
ATOM   3620 C CA  . PRO A 1 522 ? 76.287  124.975 116.009 1.00 319.97 ? 522 PRO A CA  1 
ATOM   3621 C C   . PRO A 1 522 ? 75.173  126.005 115.724 1.00 294.78 ? 522 PRO A C   1 
ATOM   3622 O O   . PRO A 1 522 ? 74.123  125.920 116.354 1.00 302.92 ? 522 PRO A O   1 
ATOM   3623 C CB  . PRO A 1 522 ? 75.980  123.670 115.249 1.00 339.99 ? 522 PRO A CB  1 
ATOM   3624 C CG  . PRO A 1 522 ? 76.619  122.583 116.088 1.00 341.26 ? 522 PRO A CG  1 
ATOM   3625 C CD  . PRO A 1 522 ? 76.426  123.056 117.514 1.00 328.35 ? 522 PRO A CD  1 
HETATM 3626 C C1  . NAG B 2 .   ? 136.141 114.251 102.203 1.00 159.06 ? 1   NAG B C1  1 
HETATM 3627 C C2  . NAG B 2 .   ? 136.274 113.986 103.695 1.00 164.45 ? 1   NAG B C2  1 
HETATM 3628 C C3  . NAG B 2 .   ? 137.725 114.152 104.127 1.00 197.73 ? 1   NAG B C3  1 
HETATM 3629 C C4  . NAG B 2 .   ? 138.643 113.301 103.262 1.00 239.69 ? 1   NAG B C4  1 
HETATM 3630 C C5  . NAG B 2 .   ? 138.413 113.611 101.787 1.00 243.83 ? 1   NAG B C5  1 
HETATM 3631 C C6  . NAG B 2 .   ? 139.202 112.704 100.869 1.00 285.05 ? 1   NAG B C6  1 
HETATM 3632 C C7  . NAG B 2 .   ? 134.334 114.507 105.119 1.00 121.15 ? 1   NAG B C7  1 
HETATM 3633 C C8  . NAG B 2 .   ? 133.787 115.506 106.091 1.00 114.84 ? 1   NAG B C8  1 
HETATM 3634 N N2  . NAG B 2 .   ? 135.437 114.878 104.472 1.00 149.33 ? 1   NAG B N2  1 
HETATM 3635 O O3  . NAG B 2 .   ? 137.848 113.808 105.501 1.00 190.10 ? 1   NAG B O3  1 
HETATM 3636 O O4  . NAG B 2 .   ? 140.002 113.604 103.596 1.00 290.75 ? 1   NAG B O4  1 
HETATM 3637 O O5  . NAG B 2 .   ? 137.023 113.419 101.459 1.00 178.51 ? 1   NAG B O5  1 
HETATM 3638 O O6  . NAG B 2 .   ? 138.874 112.922 99.495  1.00 282.90 ? 1   NAG B O6  1 
HETATM 3639 O O7  . NAG B 2 .   ? 133.787 113.432 104.905 1.00 116.60 ? 1   NAG B O7  1 
HETATM 3640 C C1  . NAG B 2 .   ? 140.790 112.567 104.085 1.00 316.11 ? 2   NAG B C1  1 
HETATM 3641 C C2  . NAG B 2 .   ? 142.226 113.063 104.059 1.00 331.09 ? 2   NAG B C2  1 
HETATM 3642 C C3  . NAG B 2 .   ? 143.154 112.008 104.650 1.00 318.66 ? 2   NAG B C3  1 
HETATM 3643 C C4  . NAG B 2 .   ? 142.682 111.619 106.044 1.00 300.59 ? 2   NAG B C4  1 
HETATM 3644 C C5  . NAG B 2 .   ? 141.223 111.172 105.991 1.00 290.28 ? 2   NAG B C5  1 
HETATM 3645 C C6  . NAG B 2 .   ? 140.646 110.891 107.358 1.00 295.96 ? 2   NAG B C6  1 
HETATM 3646 C C7  . NAG B 2 .   ? 142.766 114.698 102.318 1.00 356.26 ? 2   NAG B C7  1 
HETATM 3647 C C8  . NAG B 2 .   ? 143.149 114.900 100.883 1.00 353.20 ? 2   NAG B C8  1 
HETATM 3648 N N2  . NAG B 2 .   ? 142.628 113.432 102.718 1.00 351.38 ? 2   NAG B N2  1 
HETATM 3649 O O3  . NAG B 2 .   ? 144.487 112.500 104.681 1.00 326.52 ? 2   NAG B O3  1 
HETATM 3650 O O4  . NAG B 2 .   ? 143.486 110.550 106.531 1.00 296.74 ? 2   NAG B O4  1 
HETATM 3651 O O5  . NAG B 2 .   ? 140.412 112.215 105.415 1.00 300.60 ? 2   NAG B O5  1 
HETATM 3652 O O6  . NAG B 2 .   ? 140.649 112.065 108.168 1.00 296.34 ? 2   NAG B O6  1 
HETATM 3653 O O7  . NAG B 2 .   ? 142.592 115.643 103.080 1.00 357.07 ? 2   NAG B O7  1 
HETATM 3654 N N1  . URC C 3 .   ? 104.107 102.343 109.444 1.00 216.44 ? 601 URC A N1  1 
HETATM 3655 C C2  . URC C 3 .   ? 102.731 102.337 109.400 1.00 211.62 ? 601 URC A C2  1 
HETATM 3656 C C6  . URC C 3 .   ? 104.904 103.460 109.205 1.00 185.97 ? 601 URC A C6  1 
HETATM 3657 N N3  . URC C 3 .   ? 102.082 103.502 109.097 1.00 216.50 ? 601 URC A N3  1 
HETATM 3658 O O11 . URC C 3 .   ? 102.085 101.327 109.621 1.00 189.90 ? 601 URC A O11 1 
HETATM 3659 C C4  . URC C 3 .   ? 102.774 104.623 108.855 1.00 228.00 ? 601 URC A C4  1 
HETATM 3660 C C5  . URC C 3 .   ? 104.176 104.633 108.904 1.00 205.32 ? 601 URC A C5  1 
HETATM 3661 N N9  . URC C 3 .   ? 102.363 105.889 108.532 1.00 219.72 ? 601 URC A N9  1 
HETATM 3662 O O13 . URC C 3 .   ? 106.131 103.371 109.261 1.00 151.00 ? 601 URC A O13 1 
HETATM 3663 N N7  . URC C 3 .   ? 104.581 105.908 108.615 1.00 194.18 ? 601 URC A N7  1 
HETATM 3664 C C8  . URC C 3 .   ? 103.471 106.674 108.389 1.00 206.40 ? 601 URC A C8  1 
HETATM 3665 O O24 . URC C 3 .   ? 103.466 107.871 108.100 1.00 189.22 ? 601 URC A O24 1 
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