data_8ZWZ
# 
_entry.id   8ZWZ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZWZ         pdb_00008zwz 10.2210/pdb8zwz/pdb 
WWPDB D_1300048682 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-12 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZWZ 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-13 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              cywang@ips.ac.cn 
_pdbx_contact_author.name_first         Chengyuan 
_pdbx_contact_author.name_last          Wang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-8605-0716 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Mao, J.J.' 1 ? 
'Chen, B.'  2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Sci Adv' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2375-2548 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            11 
_citation.language                  ? 
_citation.page_first                eadv0805 
_citation.page_last                 eadv0805 
_citation.title                     
'Mining coral-derived terpene synthases and mechanistic studies of the coral biflorane synthase.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1126/sciadv.adv0805 
_citation.pdbx_database_id_PubMed   40009671 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Chen, B.'  1 0000-0001-6868-4996 
primary 'Mao, J.'   2 0009-0000-9599-3508 
primary 'Xu, K.'    3 0009-0005-0134-0458 
primary 'Liu, L.'   4 0009-0000-7555-5850 
primary 'Lin, W.'   5 0000-0002-2940-6966 
primary 'Guo, Y.W.' 6 0000-0003-0413-2070 
primary 'Wu, R.'    7 0000-0002-1984-046X 
primary 'Wang, C.'  8 0000-0002-8605-0716 
primary 'Xu, B.'    9 0000-0002-0144-2455 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'Diterpene synthase' 
_entity.formula_weight             47694.859 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;YFQGHMMIHAPRRWVERHKQVQVLPQNAVEKLISMNELIELVIECGLCDKTSIKKMYDKINTYQFMWCIVDTIPASQYAE
EIFKSSLHFLCALFLVDDAVESYSANEMQDLSRSYDILEKEVCKTFPNFPSINEMKESLMHLRNPFDRSSITFCMQYVNK
ITAILLEEGNTPHHVVYNLRRRTSNAISIAFQAVLIKSKCGSIITSHEMLWRRVFDGLVILFYQFGELISGATETAQQHI
TVVTELRMLGCLYCIVINDLYSYQRDKLASSDNMIKTWLLEKTVSSLSEATARCSQILDAIMKYMYQRVEQCMQSNPGCP
QLESLLETTIYTTVGWIRSHTTVVPRYSESQLKVALVEVEERELPKWLAEKDEYGWNVVEKFVETLNDEKHKGILDALQG
IADGRDQLLKTQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;YFQGHMMIHAPRRWVERHKQVQVLPQNAVEKLISMNELIELVIECGLCDKTSIKKMYDKINTYQFMWCIVDTIPASQYAE
EIFKSSLHFLCALFLVDDAVESYSANEMQDLSRSYDILEKEVCKTFPNFPSINEMKESLMHLRNPFDRSSITFCMQYVNK
ITAILLEEGNTPHHVVYNLRRRTSNAISIAFQAVLIKSKCGSIITSHEMLWRRVFDGLVILFYQFGELISGATETAQQHI
TVVTELRMLGCLYCIVINDLYSYQRDKLASSDNMIKTWLLEKTVSSLSEATARCSQILDAIMKYMYQRVEQCMQSNPGCP
QLESLLETTIYTTVGWIRSHTTVVPRYSESQLKVALVEVEERELPKWLAEKDEYGWNVVEKFVETLNDEKHKGILDALQG
IADGRDQLLKTQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   TYR n 
1 2   PHE n 
1 3   GLN n 
1 4   GLY n 
1 5   HIS n 
1 6   MET n 
1 7   MET n 
1 8   ILE n 
1 9   HIS n 
1 10  ALA n 
1 11  PRO n 
1 12  ARG n 
1 13  ARG n 
1 14  TRP n 
1 15  VAL n 
1 16  GLU n 
1 17  ARG n 
1 18  HIS n 
1 19  LYS n 
1 20  GLN n 
1 21  VAL n 
1 22  GLN n 
1 23  VAL n 
1 24  LEU n 
1 25  PRO n 
1 26  GLN n 
1 27  ASN n 
1 28  ALA n 
1 29  VAL n 
1 30  GLU n 
1 31  LYS n 
1 32  LEU n 
1 33  ILE n 
1 34  SER n 
1 35  MET n 
1 36  ASN n 
1 37  GLU n 
1 38  LEU n 
1 39  ILE n 
1 40  GLU n 
1 41  LEU n 
1 42  VAL n 
1 43  ILE n 
1 44  GLU n 
1 45  CYS n 
1 46  GLY n 
1 47  LEU n 
1 48  CYS n 
1 49  ASP n 
1 50  LYS n 
1 51  THR n 
1 52  SER n 
1 53  ILE n 
1 54  LYS n 
1 55  LYS n 
1 56  MET n 
1 57  TYR n 
1 58  ASP n 
1 59  LYS n 
1 60  ILE n 
1 61  ASN n 
1 62  THR n 
1 63  TYR n 
1 64  GLN n 
1 65  PHE n 
1 66  MET n 
1 67  TRP n 
1 68  CYS n 
1 69  ILE n 
1 70  VAL n 
1 71  ASP n 
1 72  THR n 
1 73  ILE n 
1 74  PRO n 
1 75  ALA n 
1 76  SER n 
1 77  GLN n 
1 78  TYR n 
1 79  ALA n 
1 80  GLU n 
1 81  GLU n 
1 82  ILE n 
1 83  PHE n 
1 84  LYS n 
1 85  SER n 
1 86  SER n 
1 87  LEU n 
1 88  HIS n 
1 89  PHE n 
1 90  LEU n 
1 91  CYS n 
1 92  ALA n 
1 93  LEU n 
1 94  PHE n 
1 95  LEU n 
1 96  VAL n 
1 97  ASP n 
1 98  ASP n 
1 99  ALA n 
1 100 VAL n 
1 101 GLU n 
1 102 SER n 
1 103 TYR n 
1 104 SER n 
1 105 ALA n 
1 106 ASN n 
1 107 GLU n 
1 108 MET n 
1 109 GLN n 
1 110 ASP n 
1 111 LEU n 
1 112 SER n 
1 113 ARG n 
1 114 SER n 
1 115 TYR n 
1 116 ASP n 
1 117 ILE n 
1 118 LEU n 
1 119 GLU n 
1 120 LYS n 
1 121 GLU n 
1 122 VAL n 
1 123 CYS n 
1 124 LYS n 
1 125 THR n 
1 126 PHE n 
1 127 PRO n 
1 128 ASN n 
1 129 PHE n 
1 130 PRO n 
1 131 SER n 
1 132 ILE n 
1 133 ASN n 
1 134 GLU n 
1 135 MET n 
1 136 LYS n 
1 137 GLU n 
1 138 SER n 
1 139 LEU n 
1 140 MET n 
1 141 HIS n 
1 142 LEU n 
1 143 ARG n 
1 144 ASN n 
1 145 PRO n 
1 146 PHE n 
1 147 ASP n 
1 148 ARG n 
1 149 SER n 
1 150 SER n 
1 151 ILE n 
1 152 THR n 
1 153 PHE n 
1 154 CYS n 
1 155 MET n 
1 156 GLN n 
1 157 TYR n 
1 158 VAL n 
1 159 ASN n 
1 160 LYS n 
1 161 ILE n 
1 162 THR n 
1 163 ALA n 
1 164 ILE n 
1 165 LEU n 
1 166 LEU n 
1 167 GLU n 
1 168 GLU n 
1 169 GLY n 
1 170 ASN n 
1 171 THR n 
1 172 PRO n 
1 173 HIS n 
1 174 HIS n 
1 175 VAL n 
1 176 VAL n 
1 177 TYR n 
1 178 ASN n 
1 179 LEU n 
1 180 ARG n 
1 181 ARG n 
1 182 ARG n 
1 183 THR n 
1 184 SER n 
1 185 ASN n 
1 186 ALA n 
1 187 ILE n 
1 188 SER n 
1 189 ILE n 
1 190 ALA n 
1 191 PHE n 
1 192 GLN n 
1 193 ALA n 
1 194 VAL n 
1 195 LEU n 
1 196 ILE n 
1 197 LYS n 
1 198 SER n 
1 199 LYS n 
1 200 CYS n 
1 201 GLY n 
1 202 SER n 
1 203 ILE n 
1 204 ILE n 
1 205 THR n 
1 206 SER n 
1 207 HIS n 
1 208 GLU n 
1 209 MET n 
1 210 LEU n 
1 211 TRP n 
1 212 ARG n 
1 213 ARG n 
1 214 VAL n 
1 215 PHE n 
1 216 ASP n 
1 217 GLY n 
1 218 LEU n 
1 219 VAL n 
1 220 ILE n 
1 221 LEU n 
1 222 PHE n 
1 223 TYR n 
1 224 GLN n 
1 225 PHE n 
1 226 GLY n 
1 227 GLU n 
1 228 LEU n 
1 229 ILE n 
1 230 SER n 
1 231 GLY n 
1 232 ALA n 
1 233 THR n 
1 234 GLU n 
1 235 THR n 
1 236 ALA n 
1 237 GLN n 
1 238 GLN n 
1 239 HIS n 
1 240 ILE n 
1 241 THR n 
1 242 VAL n 
1 243 VAL n 
1 244 THR n 
1 245 GLU n 
1 246 LEU n 
1 247 ARG n 
1 248 MET n 
1 249 LEU n 
1 250 GLY n 
1 251 CYS n 
1 252 LEU n 
1 253 TYR n 
1 254 CYS n 
1 255 ILE n 
1 256 VAL n 
1 257 ILE n 
1 258 ASN n 
1 259 ASP n 
1 260 LEU n 
1 261 TYR n 
1 262 SER n 
1 263 TYR n 
1 264 GLN n 
1 265 ARG n 
1 266 ASP n 
1 267 LYS n 
1 268 LEU n 
1 269 ALA n 
1 270 SER n 
1 271 SER n 
1 272 ASP n 
1 273 ASN n 
1 274 MET n 
1 275 ILE n 
1 276 LYS n 
1 277 THR n 
1 278 TRP n 
1 279 LEU n 
1 280 LEU n 
1 281 GLU n 
1 282 LYS n 
1 283 THR n 
1 284 VAL n 
1 285 SER n 
1 286 SER n 
1 287 LEU n 
1 288 SER n 
1 289 GLU n 
1 290 ALA n 
1 291 THR n 
1 292 ALA n 
1 293 ARG n 
1 294 CYS n 
1 295 SER n 
1 296 GLN n 
1 297 ILE n 
1 298 LEU n 
1 299 ASP n 
1 300 ALA n 
1 301 ILE n 
1 302 MET n 
1 303 LYS n 
1 304 TYR n 
1 305 MET n 
1 306 TYR n 
1 307 GLN n 
1 308 ARG n 
1 309 VAL n 
1 310 GLU n 
1 311 GLN n 
1 312 CYS n 
1 313 MET n 
1 314 GLN n 
1 315 SER n 
1 316 ASN n 
1 317 PRO n 
1 318 GLY n 
1 319 CYS n 
1 320 PRO n 
1 321 GLN n 
1 322 LEU n 
1 323 GLU n 
1 324 SER n 
1 325 LEU n 
1 326 LEU n 
1 327 GLU n 
1 328 THR n 
1 329 THR n 
1 330 ILE n 
1 331 TYR n 
1 332 THR n 
1 333 THR n 
1 334 VAL n 
1 335 GLY n 
1 336 TRP n 
1 337 ILE n 
1 338 ARG n 
1 339 SER n 
1 340 HIS n 
1 341 THR n 
1 342 THR n 
1 343 VAL n 
1 344 VAL n 
1 345 PRO n 
1 346 ARG n 
1 347 TYR n 
1 348 SER n 
1 349 GLU n 
1 350 SER n 
1 351 GLN n 
1 352 LEU n 
1 353 LYS n 
1 354 VAL n 
1 355 ALA n 
1 356 LEU n 
1 357 VAL n 
1 358 GLU n 
1 359 VAL n 
1 360 GLU n 
1 361 GLU n 
1 362 ARG n 
1 363 GLU n 
1 364 LEU n 
1 365 PRO n 
1 366 LYS n 
1 367 TRP n 
1 368 LEU n 
1 369 ALA n 
1 370 GLU n 
1 371 LYS n 
1 372 ASP n 
1 373 GLU n 
1 374 TYR n 
1 375 GLY n 
1 376 TRP n 
1 377 ASN n 
1 378 VAL n 
1 379 VAL n 
1 380 GLU n 
1 381 LYS n 
1 382 PHE n 
1 383 VAL n 
1 384 GLU n 
1 385 THR n 
1 386 LEU n 
1 387 ASN n 
1 388 ASP n 
1 389 GLU n 
1 390 LYS n 
1 391 HIS n 
1 392 LYS n 
1 393 GLY n 
1 394 ILE n 
1 395 LEU n 
1 396 ASP n 
1 397 ALA n 
1 398 LEU n 
1 399 GLN n 
1 400 GLY n 
1 401 ILE n 
1 402 ALA n 
1 403 ASP n 
1 404 GLY n 
1 405 ARG n 
1 406 ASP n 
1 407 GLN n 
1 408 LEU n 
1 409 LEU n 
1 410 LYS n 
1 411 THR n 
1 412 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   412 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PACLA_8A045082 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Paramuricea clavata' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     317549 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   TYR 1   -5  -5  TYR TYR A . n 
A 1 2   PHE 2   -4  -4  PHE PHE A . n 
A 1 3   GLN 3   -3  -3  GLN GLN A . n 
A 1 4   GLY 4   -2  -2  GLY GLY A . n 
A 1 5   HIS 5   -1  -1  HIS HIS A . n 
A 1 6   MET 6   0   0   MET MET A . n 
A 1 7   MET 7   1   1   MET MET A . n 
A 1 8   ILE 8   2   2   ILE ILE A . n 
A 1 9   HIS 9   3   3   HIS HIS A . n 
A 1 10  ALA 10  4   4   ALA ALA A . n 
A 1 11  PRO 11  5   5   PRO PRO A . n 
A 1 12  ARG 12  6   6   ARG ARG A . n 
A 1 13  ARG 13  7   7   ARG ARG A . n 
A 1 14  TRP 14  8   8   TRP TRP A . n 
A 1 15  VAL 15  9   9   VAL VAL A . n 
A 1 16  GLU 16  10  10  GLU GLU A . n 
A 1 17  ARG 17  11  11  ARG ARG A . n 
A 1 18  HIS 18  12  12  HIS HIS A . n 
A 1 19  LYS 19  13  13  LYS LYS A . n 
A 1 20  GLN 20  14  14  GLN GLN A . n 
A 1 21  VAL 21  15  15  VAL VAL A . n 
A 1 22  GLN 22  16  16  GLN GLN A . n 
A 1 23  VAL 23  17  17  VAL VAL A . n 
A 1 24  LEU 24  18  18  LEU LEU A . n 
A 1 25  PRO 25  19  19  PRO PRO A . n 
A 1 26  GLN 26  20  20  GLN GLN A . n 
A 1 27  ASN 27  21  21  ASN ASN A . n 
A 1 28  ALA 28  22  22  ALA ALA A . n 
A 1 29  VAL 29  23  23  VAL VAL A . n 
A 1 30  GLU 30  24  24  GLU GLU A . n 
A 1 31  LYS 31  25  25  LYS LYS A . n 
A 1 32  LEU 32  26  26  LEU LEU A . n 
A 1 33  ILE 33  27  27  ILE ILE A . n 
A 1 34  SER 34  28  28  SER SER A . n 
A 1 35  MET 35  29  29  MET MET A . n 
A 1 36  ASN 36  30  30  ASN ASN A . n 
A 1 37  GLU 37  31  31  GLU GLU A . n 
A 1 38  LEU 38  32  32  LEU LEU A . n 
A 1 39  ILE 39  33  33  ILE ILE A . n 
A 1 40  GLU 40  34  34  GLU GLU A . n 
A 1 41  LEU 41  35  35  LEU LEU A . n 
A 1 42  VAL 42  36  36  VAL VAL A . n 
A 1 43  ILE 43  37  37  ILE ILE A . n 
A 1 44  GLU 44  38  38  GLU GLU A . n 
A 1 45  CYS 45  39  39  CYS CYS A . n 
A 1 46  GLY 46  40  40  GLY GLY A . n 
A 1 47  LEU 47  41  41  LEU LEU A . n 
A 1 48  CYS 48  42  42  CYS CYS A . n 
A 1 49  ASP 49  43  43  ASP ASP A . n 
A 1 50  LYS 50  44  44  LYS LYS A . n 
A 1 51  THR 51  45  45  THR THR A . n 
A 1 52  SER 52  46  46  SER SER A . n 
A 1 53  ILE 53  47  47  ILE ILE A . n 
A 1 54  LYS 54  48  48  LYS LYS A . n 
A 1 55  LYS 55  49  49  LYS LYS A . n 
A 1 56  MET 56  50  50  MET MET A . n 
A 1 57  TYR 57  51  51  TYR TYR A . n 
A 1 58  ASP 58  52  52  ASP ASP A . n 
A 1 59  LYS 59  53  53  LYS LYS A . n 
A 1 60  ILE 60  54  54  ILE ILE A . n 
A 1 61  ASN 61  55  55  ASN ASN A . n 
A 1 62  THR 62  56  56  THR THR A . n 
A 1 63  TYR 63  57  57  TYR TYR A . n 
A 1 64  GLN 64  58  58  GLN GLN A . n 
A 1 65  PHE 65  59  59  PHE PHE A . n 
A 1 66  MET 66  60  60  MET MET A . n 
A 1 67  TRP 67  61  61  TRP TRP A . n 
A 1 68  CYS 68  62  62  CYS CYS A . n 
A 1 69  ILE 69  63  63  ILE ILE A . n 
A 1 70  VAL 70  64  64  VAL VAL A . n 
A 1 71  ASP 71  65  65  ASP ASP A . n 
A 1 72  THR 72  66  66  THR THR A . n 
A 1 73  ILE 73  67  67  ILE ILE A . n 
A 1 74  PRO 74  68  68  PRO PRO A . n 
A 1 75  ALA 75  69  69  ALA ALA A . n 
A 1 76  SER 76  70  70  SER SER A . n 
A 1 77  GLN 77  71  71  GLN GLN A . n 
A 1 78  TYR 78  72  72  TYR TYR A . n 
A 1 79  ALA 79  73  73  ALA ALA A . n 
A 1 80  GLU 80  74  74  GLU GLU A . n 
A 1 81  GLU 81  75  75  GLU GLU A . n 
A 1 82  ILE 82  76  76  ILE ILE A . n 
A 1 83  PHE 83  77  77  PHE PHE A . n 
A 1 84  LYS 84  78  78  LYS LYS A . n 
A 1 85  SER 85  79  79  SER SER A . n 
A 1 86  SER 86  80  80  SER SER A . n 
A 1 87  LEU 87  81  81  LEU LEU A . n 
A 1 88  HIS 88  82  82  HIS HIS A . n 
A 1 89  PHE 89  83  83  PHE PHE A . n 
A 1 90  LEU 90  84  84  LEU LEU A . n 
A 1 91  CYS 91  85  85  CYS CYS A . n 
A 1 92  ALA 92  86  86  ALA ALA A . n 
A 1 93  LEU 93  87  87  LEU LEU A . n 
A 1 94  PHE 94  88  88  PHE PHE A . n 
A 1 95  LEU 95  89  89  LEU LEU A . n 
A 1 96  VAL 96  90  90  VAL VAL A . n 
A 1 97  ASP 97  91  91  ASP ASP A . n 
A 1 98  ASP 98  92  92  ASP ASP A . n 
A 1 99  ALA 99  93  93  ALA ALA A . n 
A 1 100 VAL 100 94  94  VAL VAL A . n 
A 1 101 GLU 101 95  95  GLU GLU A . n 
A 1 102 SER 102 96  96  SER SER A . n 
A 1 103 TYR 103 97  97  TYR TYR A . n 
A 1 104 SER 104 98  98  SER SER A . n 
A 1 105 ALA 105 99  99  ALA ALA A . n 
A 1 106 ASN 106 100 100 ASN ASN A . n 
A 1 107 GLU 107 101 101 GLU GLU A . n 
A 1 108 MET 108 102 102 MET MET A . n 
A 1 109 GLN 109 103 103 GLN GLN A . n 
A 1 110 ASP 110 104 104 ASP ASP A . n 
A 1 111 LEU 111 105 105 LEU LEU A . n 
A 1 112 SER 112 106 106 SER SER A . n 
A 1 113 ARG 113 107 107 ARG ARG A . n 
A 1 114 SER 114 108 108 SER SER A . n 
A 1 115 TYR 115 109 109 TYR TYR A . n 
A 1 116 ASP 116 110 110 ASP ASP A . n 
A 1 117 ILE 117 111 111 ILE ILE A . n 
A 1 118 LEU 118 112 112 LEU LEU A . n 
A 1 119 GLU 119 113 113 GLU GLU A . n 
A 1 120 LYS 120 114 114 LYS LYS A . n 
A 1 121 GLU 121 115 115 GLU GLU A . n 
A 1 122 VAL 122 116 116 VAL VAL A . n 
A 1 123 CYS 123 117 117 CYS CYS A . n 
A 1 124 LYS 124 118 118 LYS LYS A . n 
A 1 125 THR 125 119 119 THR THR A . n 
A 1 126 PHE 126 120 120 PHE PHE A . n 
A 1 127 PRO 127 121 121 PRO PRO A . n 
A 1 128 ASN 128 122 122 ASN ASN A . n 
A 1 129 PHE 129 123 123 PHE PHE A . n 
A 1 130 PRO 130 124 124 PRO PRO A . n 
A 1 131 SER 131 125 125 SER SER A . n 
A 1 132 ILE 132 126 126 ILE ILE A . n 
A 1 133 ASN 133 127 127 ASN ASN A . n 
A 1 134 GLU 134 128 128 GLU GLU A . n 
A 1 135 MET 135 129 129 MET MET A . n 
A 1 136 LYS 136 130 130 LYS LYS A . n 
A 1 137 GLU 137 131 131 GLU GLU A . n 
A 1 138 SER 138 132 132 SER SER A . n 
A 1 139 LEU 139 133 133 LEU LEU A . n 
A 1 140 MET 140 134 134 MET MET A . n 
A 1 141 HIS 141 135 135 HIS HIS A . n 
A 1 142 LEU 142 136 136 LEU LEU A . n 
A 1 143 ARG 143 137 137 ARG ARG A . n 
A 1 144 ASN 144 138 138 ASN ASN A . n 
A 1 145 PRO 145 139 139 PRO PRO A . n 
A 1 146 PHE 146 140 140 PHE PHE A . n 
A 1 147 ASP 147 141 141 ASP ASP A . n 
A 1 148 ARG 148 142 142 ARG ARG A . n 
A 1 149 SER 149 143 143 SER SER A . n 
A 1 150 SER 150 144 144 SER SER A . n 
A 1 151 ILE 151 145 145 ILE ILE A . n 
A 1 152 THR 152 146 146 THR THR A . n 
A 1 153 PHE 153 147 147 PHE PHE A . n 
A 1 154 CYS 154 148 148 CYS CYS A . n 
A 1 155 MET 155 149 149 MET MET A . n 
A 1 156 GLN 156 150 150 GLN GLN A . n 
A 1 157 TYR 157 151 151 TYR TYR A . n 
A 1 158 VAL 158 152 152 VAL VAL A . n 
A 1 159 ASN 159 153 153 ASN ASN A . n 
A 1 160 LYS 160 154 154 LYS LYS A . n 
A 1 161 ILE 161 155 155 ILE ILE A . n 
A 1 162 THR 162 156 156 THR THR A . n 
A 1 163 ALA 163 157 157 ALA ALA A . n 
A 1 164 ILE 164 158 158 ILE ILE A . n 
A 1 165 LEU 165 159 159 LEU LEU A . n 
A 1 166 LEU 166 160 160 LEU LEU A . n 
A 1 167 GLU 167 161 161 GLU GLU A . n 
A 1 168 GLU 168 162 162 GLU GLU A . n 
A 1 169 GLY 169 163 163 GLY GLY A . n 
A 1 170 ASN 170 164 164 ASN ASN A . n 
A 1 171 THR 171 165 165 THR THR A . n 
A 1 172 PRO 172 166 166 PRO PRO A . n 
A 1 173 HIS 173 167 167 HIS HIS A . n 
A 1 174 HIS 174 168 168 HIS HIS A . n 
A 1 175 VAL 175 169 169 VAL VAL A . n 
A 1 176 VAL 176 170 170 VAL VAL A . n 
A 1 177 TYR 177 171 171 TYR TYR A . n 
A 1 178 ASN 178 172 172 ASN ASN A . n 
A 1 179 LEU 179 173 173 LEU LEU A . n 
A 1 180 ARG 180 174 174 ARG ARG A . n 
A 1 181 ARG 181 175 175 ARG ARG A . n 
A 1 182 ARG 182 176 176 ARG ARG A . n 
A 1 183 THR 183 177 177 THR THR A . n 
A 1 184 SER 184 178 178 SER SER A . n 
A 1 185 ASN 185 179 179 ASN ASN A . n 
A 1 186 ALA 186 180 180 ALA ALA A . n 
A 1 187 ILE 187 181 181 ILE ILE A . n 
A 1 188 SER 188 182 182 SER SER A . n 
A 1 189 ILE 189 183 183 ILE ILE A . n 
A 1 190 ALA 190 184 184 ALA ALA A . n 
A 1 191 PHE 191 185 185 PHE PHE A . n 
A 1 192 GLN 192 186 186 GLN GLN A . n 
A 1 193 ALA 193 187 187 ALA ALA A . n 
A 1 194 VAL 194 188 188 VAL VAL A . n 
A 1 195 LEU 195 189 189 LEU LEU A . n 
A 1 196 ILE 196 190 190 ILE ILE A . n 
A 1 197 LYS 197 191 191 LYS LYS A . n 
A 1 198 SER 198 192 192 SER SER A . n 
A 1 199 LYS 199 193 193 LYS LYS A . n 
A 1 200 CYS 200 194 194 CYS CYS A . n 
A 1 201 GLY 201 195 195 GLY GLY A . n 
A 1 202 SER 202 196 196 SER SER A . n 
A 1 203 ILE 203 197 ?   ?   ?   A . n 
A 1 204 ILE 204 198 198 ILE ILE A . n 
A 1 205 THR 205 199 199 THR THR A . n 
A 1 206 SER 206 200 200 SER SER A . n 
A 1 207 HIS 207 201 201 HIS HIS A . n 
A 1 208 GLU 208 202 202 GLU GLU A . n 
A 1 209 MET 209 203 203 MET MET A . n 
A 1 210 LEU 210 204 204 LEU LEU A . n 
A 1 211 TRP 211 205 205 TRP TRP A . n 
A 1 212 ARG 212 206 206 ARG ARG A . n 
A 1 213 ARG 213 207 207 ARG ARG A . n 
A 1 214 VAL 214 208 208 VAL VAL A . n 
A 1 215 PHE 215 209 209 PHE PHE A . n 
A 1 216 ASP 216 210 210 ASP ASP A . n 
A 1 217 GLY 217 211 211 GLY GLY A . n 
A 1 218 LEU 218 212 212 LEU LEU A . n 
A 1 219 VAL 219 213 213 VAL VAL A . n 
A 1 220 ILE 220 214 214 ILE ILE A . n 
A 1 221 LEU 221 215 215 LEU LEU A . n 
A 1 222 PHE 222 216 216 PHE PHE A . n 
A 1 223 TYR 223 217 217 TYR TYR A . n 
A 1 224 GLN 224 218 218 GLN GLN A . n 
A 1 225 PHE 225 219 219 PHE PHE A . n 
A 1 226 GLY 226 220 220 GLY GLY A . n 
A 1 227 GLU 227 221 221 GLU GLU A . n 
A 1 228 LEU 228 222 222 LEU LEU A . n 
A 1 229 ILE 229 223 223 ILE ILE A . n 
A 1 230 SER 230 224 224 SER SER A . n 
A 1 231 GLY 231 225 225 GLY GLY A . n 
A 1 232 ALA 232 226 226 ALA ALA A . n 
A 1 233 THR 233 227 227 THR THR A . n 
A 1 234 GLU 234 228 228 GLU GLU A . n 
A 1 235 THR 235 229 229 THR THR A . n 
A 1 236 ALA 236 230 230 ALA ALA A . n 
A 1 237 GLN 237 231 231 GLN GLN A . n 
A 1 238 GLN 238 232 232 GLN GLN A . n 
A 1 239 HIS 239 233 233 HIS HIS A . n 
A 1 240 ILE 240 234 234 ILE ILE A . n 
A 1 241 THR 241 235 235 THR THR A . n 
A 1 242 VAL 242 236 236 VAL VAL A . n 
A 1 243 VAL 243 237 237 VAL VAL A . n 
A 1 244 THR 244 238 238 THR THR A . n 
A 1 245 GLU 245 239 239 GLU GLU A . n 
A 1 246 LEU 246 240 240 LEU LEU A . n 
A 1 247 ARG 247 241 241 ARG ARG A . n 
A 1 248 MET 248 242 242 MET MET A . n 
A 1 249 LEU 249 243 243 LEU LEU A . n 
A 1 250 GLY 250 244 244 GLY GLY A . n 
A 1 251 CYS 251 245 245 CYS CYS A . n 
A 1 252 LEU 252 246 246 LEU LEU A . n 
A 1 253 TYR 253 247 247 TYR TYR A . n 
A 1 254 CYS 254 248 248 CYS CYS A . n 
A 1 255 ILE 255 249 249 ILE ILE A . n 
A 1 256 VAL 256 250 250 VAL VAL A . n 
A 1 257 ILE 257 251 251 ILE ILE A . n 
A 1 258 ASN 258 252 252 ASN ASN A . n 
A 1 259 ASP 259 253 253 ASP ASP A . n 
A 1 260 LEU 260 254 254 LEU LEU A . n 
A 1 261 TYR 261 255 255 TYR TYR A . n 
A 1 262 SER 262 256 256 SER SER A . n 
A 1 263 TYR 263 257 257 TYR TYR A . n 
A 1 264 GLN 264 258 258 GLN GLN A . n 
A 1 265 ARG 265 259 259 ARG ARG A . n 
A 1 266 ASP 266 260 260 ASP ASP A . n 
A 1 267 LYS 267 261 261 LYS LYS A . n 
A 1 268 LEU 268 262 262 LEU LEU A . n 
A 1 269 ALA 269 263 263 ALA ALA A . n 
A 1 270 SER 270 264 264 SER SER A . n 
A 1 271 SER 271 265 265 SER SER A . n 
A 1 272 ASP 272 266 266 ASP ASP A . n 
A 1 273 ASN 273 267 267 ASN ASN A . n 
A 1 274 MET 274 268 268 MET MET A . n 
A 1 275 ILE 275 269 269 ILE ILE A . n 
A 1 276 LYS 276 270 270 LYS LYS A . n 
A 1 277 THR 277 271 271 THR THR A . n 
A 1 278 TRP 278 272 272 TRP TRP A . n 
A 1 279 LEU 279 273 273 LEU LEU A . n 
A 1 280 LEU 280 274 274 LEU LEU A . n 
A 1 281 GLU 281 275 275 GLU GLU A . n 
A 1 282 LYS 282 276 276 LYS LYS A . n 
A 1 283 THR 283 277 277 THR THR A . n 
A 1 284 VAL 284 278 278 VAL VAL A . n 
A 1 285 SER 285 279 279 SER SER A . n 
A 1 286 SER 286 280 280 SER SER A . n 
A 1 287 LEU 287 281 281 LEU LEU A . n 
A 1 288 SER 288 282 282 SER SER A . n 
A 1 289 GLU 289 283 283 GLU GLU A . n 
A 1 290 ALA 290 284 284 ALA ALA A . n 
A 1 291 THR 291 285 285 THR THR A . n 
A 1 292 ALA 292 286 286 ALA ALA A . n 
A 1 293 ARG 293 287 287 ARG ARG A . n 
A 1 294 CYS 294 288 288 CYS CYS A . n 
A 1 295 SER 295 289 289 SER SER A . n 
A 1 296 GLN 296 290 290 GLN GLN A . n 
A 1 297 ILE 297 291 291 ILE ILE A . n 
A 1 298 LEU 298 292 292 LEU LEU A . n 
A 1 299 ASP 299 293 293 ASP ASP A . n 
A 1 300 ALA 300 294 294 ALA ALA A . n 
A 1 301 ILE 301 295 295 ILE ILE A . n 
A 1 302 MET 302 296 296 MET MET A . n 
A 1 303 LYS 303 297 297 LYS LYS A . n 
A 1 304 TYR 304 298 298 TYR TYR A . n 
A 1 305 MET 305 299 299 MET MET A . n 
A 1 306 TYR 306 300 300 TYR TYR A . n 
A 1 307 GLN 307 301 301 GLN GLN A . n 
A 1 308 ARG 308 302 302 ARG ARG A . n 
A 1 309 VAL 309 303 303 VAL VAL A . n 
A 1 310 GLU 310 304 304 GLU GLU A . n 
A 1 311 GLN 311 305 305 GLN GLN A . n 
A 1 312 CYS 312 306 306 CYS CYS A . n 
A 1 313 MET 313 307 307 MET MET A . n 
A 1 314 GLN 314 308 308 GLN GLN A . n 
A 1 315 SER 315 309 309 SER SER A . n 
A 1 316 ASN 316 310 310 ASN ASN A . n 
A 1 317 PRO 317 311 311 PRO PRO A . n 
A 1 318 GLY 318 312 312 GLY GLY A . n 
A 1 319 CYS 319 313 313 CYS CYS A . n 
A 1 320 PRO 320 314 314 PRO PRO A . n 
A 1 321 GLN 321 315 315 GLN GLN A . n 
A 1 322 LEU 322 316 316 LEU LEU A . n 
A 1 323 GLU 323 317 317 GLU GLU A . n 
A 1 324 SER 324 318 318 SER SER A . n 
A 1 325 LEU 325 319 319 LEU LEU A . n 
A 1 326 LEU 326 320 320 LEU LEU A . n 
A 1 327 GLU 327 321 321 GLU GLU A . n 
A 1 328 THR 328 322 322 THR THR A . n 
A 1 329 THR 329 323 323 THR THR A . n 
A 1 330 ILE 330 324 324 ILE ILE A . n 
A 1 331 TYR 331 325 325 TYR TYR A . n 
A 1 332 THR 332 326 326 THR THR A . n 
A 1 333 THR 333 327 327 THR THR A . n 
A 1 334 VAL 334 328 328 VAL VAL A . n 
A 1 335 GLY 335 329 329 GLY GLY A . n 
A 1 336 TRP 336 330 330 TRP TRP A . n 
A 1 337 ILE 337 331 331 ILE ILE A . n 
A 1 338 ARG 338 332 332 ARG ARG A . n 
A 1 339 SER 339 333 333 SER SER A . n 
A 1 340 HIS 340 334 334 HIS HIS A . n 
A 1 341 THR 341 335 335 THR THR A . n 
A 1 342 THR 342 336 336 THR THR A . n 
A 1 343 VAL 343 337 337 VAL VAL A . n 
A 1 344 VAL 344 338 338 VAL VAL A . n 
A 1 345 PRO 345 339 339 PRO PRO A . n 
A 1 346 ARG 346 340 340 ARG ARG A . n 
A 1 347 TYR 347 341 341 TYR TYR A . n 
A 1 348 SER 348 342 342 SER SER A . n 
A 1 349 GLU 349 343 343 GLU GLU A . n 
A 1 350 SER 350 344 344 SER SER A . n 
A 1 351 GLN 351 345 345 GLN GLN A . n 
A 1 352 LEU 352 346 346 LEU LEU A . n 
A 1 353 LYS 353 347 347 LYS LYS A . n 
A 1 354 VAL 354 348 348 VAL VAL A . n 
A 1 355 ALA 355 349 349 ALA ALA A . n 
A 1 356 LEU 356 350 350 LEU LEU A . n 
A 1 357 VAL 357 351 351 VAL VAL A . n 
A 1 358 GLU 358 352 352 GLU GLU A . n 
A 1 359 VAL 359 353 353 VAL VAL A . n 
A 1 360 GLU 360 354 354 GLU GLU A . n 
A 1 361 GLU 361 355 355 GLU GLU A . n 
A 1 362 ARG 362 356 356 ARG ARG A . n 
A 1 363 GLU 363 357 357 GLU GLU A . n 
A 1 364 LEU 364 358 358 LEU LEU A . n 
A 1 365 PRO 365 359 359 PRO PRO A . n 
A 1 366 LYS 366 360 360 LYS LYS A . n 
A 1 367 TRP 367 361 361 TRP TRP A . n 
A 1 368 LEU 368 362 362 LEU LEU A . n 
A 1 369 ALA 369 363 363 ALA ALA A . n 
A 1 370 GLU 370 364 364 GLU GLU A . n 
A 1 371 LYS 371 365 365 LYS LYS A . n 
A 1 372 ASP 372 366 366 ASP ASP A . n 
A 1 373 GLU 373 367 367 GLU GLU A . n 
A 1 374 TYR 374 368 368 TYR TYR A . n 
A 1 375 GLY 375 369 369 GLY GLY A . n 
A 1 376 TRP 376 370 370 TRP TRP A . n 
A 1 377 ASN 377 371 371 ASN ASN A . n 
A 1 378 VAL 378 372 372 VAL VAL A . n 
A 1 379 VAL 379 373 373 VAL VAL A . n 
A 1 380 GLU 380 374 374 GLU GLU A . n 
A 1 381 LYS 381 375 375 LYS LYS A . n 
A 1 382 PHE 382 376 376 PHE PHE A . n 
A 1 383 VAL 383 377 377 VAL VAL A . n 
A 1 384 GLU 384 378 378 GLU GLU A . n 
A 1 385 THR 385 379 379 THR THR A . n 
A 1 386 LEU 386 380 380 LEU LEU A . n 
A 1 387 ASN 387 381 381 ASN ASN A . n 
A 1 388 ASP 388 382 382 ASP ASP A . n 
A 1 389 GLU 389 383 383 GLU GLU A . n 
A 1 390 LYS 390 384 384 LYS LYS A . n 
A 1 391 HIS 391 385 385 HIS HIS A . n 
A 1 392 LYS 392 386 386 LYS LYS A . n 
A 1 393 GLY 393 387 387 GLY GLY A . n 
A 1 394 ILE 394 388 388 ILE ILE A . n 
A 1 395 LEU 395 389 389 LEU LEU A . n 
A 1 396 ASP 396 390 390 ASP ASP A . n 
A 1 397 ALA 397 391 391 ALA ALA A . n 
A 1 398 LEU 398 392 392 LEU LEU A . n 
A 1 399 GLN 399 393 393 GLN GLN A . n 
A 1 400 GLY 400 394 394 GLY GLY A . n 
A 1 401 ILE 401 395 395 ILE ILE A . n 
A 1 402 ALA 402 396 396 ALA ALA A . n 
A 1 403 ASP 403 397 397 ASP ASP A . n 
A 1 404 GLY 404 398 398 GLY GLY A . n 
A 1 405 ARG 405 399 399 ARG ARG A . n 
A 1 406 ASP 406 400 400 ASP ASP A . n 
A 1 407 GLN 407 401 401 GLN GLN A . n 
A 1 408 LEU 408 402 402 LEU LEU A . n 
A 1 409 LEU 409 403 403 LEU LEU A . n 
A 1 410 LYS 410 404 404 LYS LYS A . n 
A 1 411 THR 411 405 405 THR THR A . n 
A 1 412 GLN 412 406 406 GLN GLN A . n 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? '(1.20.1_4487: ???)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DIALS  ? ? ? .                    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? DIALS  ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZWZ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     85.284 
_cell.length_a_esd                 ? 
_cell.length_b                     85.284 
_cell.length_b_esd                 ? 
_cell.length_c                     106.137 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZWZ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZWZ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.34 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          47.35 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.2 M Tri-lithium citrate 
20%  polyethylene glycol (PEG) 3350
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     80 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 S 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-12-23 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97918 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL10U2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97918 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL10U2 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8ZWZ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              3.5 
_reflns.d_resolution_low                               73.86 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     5948 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.78 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                17.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          2.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.967 
_reflns.pdbx_CC_star                                   0.992 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    3.501 
_reflns_shell.d_res_low                                     3.626 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             572 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.807 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZWZ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.50 
_refine.ls_d_res_low                             73.86 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     5925 
_refine.ls_number_reflns_R_free                  266 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.78 
_refine.ls_percent_reflns_R_free                 4.49 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2612 
_refine.ls_R_factor_R_free                       0.2956 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2597 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.75 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.41 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       3.50 
_refine_hist.d_res_low                        73.86 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               3330 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3330 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.004 ? ?   ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.690 ? ?   ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 5.929 ? 445 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.043 ? 522 ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.005 ? 578 ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 3.50 4.41  . . 130 2773 100.00 . . . . 0.2802 . . . . . . . . . . . . . . . 0.3362 
'X-RAY DIFFRACTION' 4.41 73.86 . . 136 2886 100.00 . . . . 0.2454 . . . . . . . . . . . . . . . 0.2640 
# 
_struct.entry_id                     8ZWZ 
_struct.title                        'terpene synthases with from Paramuricea clavata' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZWZ 
_struct_keywords.text            'terpene synthases, coral, complex, Mg, alpha helix, BIOSYNTHETIC PROTEIN' 
_struct_keywords.pdbx_keywords   'BIOSYNTHETIC PROTEIN' 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A6S7HXL7_PARCT 
_struct_ref.pdbx_db_accession          A0A6S7HXL7 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;IHAPRRWVERHKQVQVLPQNAVEKLISMNELIELVIECGLCDKTSIKKMYDKINTYQFMWCIVDTIPASQYAEEIFKSSL
HFLCALFLVDDAVESYSANEMQDLSRSYDILEKEVCKTFPNFPSINEMKESLMHLRNPFDRSSITFCMQYVNKITAILLE
EGNTPHHVVYNLRRRTSNAISIAFQAVLIKSKCGSIITSHEMLWRRVFDGLVILFYQFGELISGATETAQQHITVVTELR
MLGCLYCIVINDLYSYQRDKLASSDNMIKTWLLEKTVSSLSEATARCSQILDAIMKYMYQRVEQCMQSNPGCPQLESLLE
TTIYTTVGWIRSHTTVVPRYSESQLKVALVEVEERELPKWLAEKDEYGWNVVEKFVETLNDEKHKGILDALQGIADGRDQ
LLKTQ
;
_struct_ref.pdbx_align_begin           7 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8ZWZ 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 8 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 412 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A6S7HXL7 
_struct_ref_seq.db_align_beg                  7 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  411 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       2 
_struct_ref_seq.pdbx_auth_seq_align_end       406 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZWZ TYR A 1 ? UNP A0A6S7HXL7 ? ? 'expression tag' -5 1 
1 8ZWZ PHE A 2 ? UNP A0A6S7HXL7 ? ? 'expression tag' -4 2 
1 8ZWZ GLN A 3 ? UNP A0A6S7HXL7 ? ? 'expression tag' -3 3 
1 8ZWZ GLY A 4 ? UNP A0A6S7HXL7 ? ? 'expression tag' -2 4 
1 8ZWZ HIS A 5 ? UNP A0A6S7HXL7 ? ? 'expression tag' -1 5 
1 8ZWZ MET A 6 ? UNP A0A6S7HXL7 ? ? 'expression tag' 0  6 
1 8ZWZ MET A 7 ? UNP A0A6S7HXL7 ? ? 'expression tag' 1  7 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ARG A 12  ? GLU A 16  ? ARG A 6   GLU A 10  1 ? 5  
HELX_P HELX_P2  AA2 PRO A 25  ? ILE A 33  ? PRO A 19  ILE A 27  1 ? 9  
HELX_P HELX_P3  AA3 SER A 34  ? CYS A 45  ? SER A 28  CYS A 39  1 ? 12 
HELX_P HELX_P4  AA4 ASP A 49  ? ASN A 61  ? ASP A 43  ASN A 55  1 ? 13 
HELX_P HELX_P5  AA5 ASN A 61  ? CYS A 68  ? ASN A 55  CYS A 62  1 ? 8  
HELX_P HELX_P6  AA6 SER A 76  ? GLU A 101 ? SER A 70  GLU A 95  1 ? 26 
HELX_P HELX_P7  AA7 SER A 104 ? CYS A 123 ? SER A 98  CYS A 117 1 ? 20 
HELX_P HELX_P8  AA8 SER A 131 ? GLU A 137 ? SER A 125 GLU A 131 1 ? 7  
HELX_P HELX_P9  AA9 SER A 138 ? MET A 140 ? SER A 132 MET A 134 5 ? 3  
HELX_P HELX_P10 AB1 ASN A 144 ? GLU A 168 ? ASN A 138 GLU A 162 1 ? 25 
HELX_P HELX_P11 AB2 PRO A 172 ? LYS A 197 ? PRO A 166 LYS A 191 1 ? 26 
HELX_P HELX_P12 AB3 HIS A 207 ? ASP A 216 ? HIS A 201 ASP A 210 1 ? 10 
HELX_P HELX_P13 AB4 VAL A 219 ? SER A 230 ? VAL A 213 SER A 224 1 ? 12 
HELX_P HELX_P14 AB5 ALA A 232 ? GLN A 238 ? ALA A 226 GLN A 232 1 ? 7  
HELX_P HELX_P15 AB6 HIS A 239 ? TYR A 263 ? HIS A 233 TYR A 257 1 ? 25 
HELX_P HELX_P16 AB7 ASN A 273 ? LYS A 282 ? ASN A 267 LYS A 276 1 ? 10 
HELX_P HELX_P17 AB8 SER A 285 ? ASN A 316 ? SER A 279 ASN A 310 1 ? 32 
HELX_P HELX_P18 AB9 CYS A 319 ? VAL A 343 ? CYS A 313 VAL A 337 1 ? 25 
HELX_P HELX_P19 AC1 GLU A 360 ? ARG A 362 ? GLU A 354 ARG A 356 5 ? 3  
HELX_P HELX_P20 AC2 GLU A 363 ? ALA A 369 ? GLU A 357 ALA A 363 1 ? 7  
HELX_P HELX_P21 AC3 GLU A 373 ? ASN A 387 ? GLU A 367 ASN A 381 1 ? 15 
HELX_P HELX_P22 AC4 ASP A 388 ? LYS A 390 ? ASP A 382 LYS A 384 5 ? 3  
HELX_P HELX_P23 AC5 HIS A 391 ? GLN A 399 ? HIS A 385 GLN A 393 1 ? 9  
HELX_P HELX_P24 AC6 ASP A 406 ? THR A 411 ? ASP A 400 THR A 405 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          PHE 
_struct_mon_prot_cis.label_seq_id           126 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           PHE 
_struct_mon_prot_cis.auth_seq_id            120 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    127 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     121 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       1.24 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   2 
_struct_sheet.details          ? 
# 
_struct_sheet_order.sheet_id     AA1 
_struct_sheet_order.range_id_1   1 
_struct_sheet_order.range_id_2   2 
_struct_sheet_order.offset       ? 
_struct_sheet_order.sense        parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 MET A 6   ? PRO A 11  ? MET A 0   PRO A 5   
AA1 2 VAL A 354 ? VAL A 359 ? VAL A 348 VAL A 353 
# 
_pdbx_struct_sheet_hbond.sheet_id                AA1 
_pdbx_struct_sheet_hbond.range_id_1              1 
_pdbx_struct_sheet_hbond.range_id_2              2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id   N 
_pdbx_struct_sheet_hbond.range_1_label_comp_id   MET 
_pdbx_struct_sheet_hbond.range_1_label_asym_id   A 
_pdbx_struct_sheet_hbond.range_1_label_seq_id    6 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code    ? 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id    N 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id    MET 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id    A 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id     0 
_pdbx_struct_sheet_hbond.range_2_label_atom_id   O 
_pdbx_struct_sheet_hbond.range_2_label_comp_id   ALA 
_pdbx_struct_sheet_hbond.range_2_label_asym_id   A 
_pdbx_struct_sheet_hbond.range_2_label_seq_id    355 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code    ? 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id    O 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id    ALA 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id    A 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id     349 
# 
_pdbx_entry_details.entry_id                   8ZWZ 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 PHE A -4  ? ? -143.48 -149.92 
2  1 LEU A 41  ? ? -61.07  -78.72  
3  1 LYS A 191 ? ? -60.84  3.49    
4  1 VAL A 236 ? ? 68.70   -51.11  
5  1 SER A 264 ? ? 54.27   -144.34 
6  1 SER A 265 ? ? 54.37   -154.61 
7  1 GLU A 275 ? ? -132.96 -49.30  
8  1 VAL A 278 ? ? -93.22  -90.34  
9  1 SER A 280 ? ? -67.82  -78.89  
10 1 TYR A 341 ? ? -76.60  41.77   
11 1 GLU A 343 ? ? 66.45   -17.89  
12 1 GLU A 364 ? ? -90.77  31.82   
# 
_pdbx_unobs_or_zero_occ_residues.id               1 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num    1 
_pdbx_unobs_or_zero_occ_residues.polymer_flag     Y 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag   1 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id     A 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id     ILE 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id      197 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code     ? 
_pdbx_unobs_or_zero_occ_residues.label_asym_id    A 
_pdbx_unobs_or_zero_occ_residues.label_comp_id    ILE 
_pdbx_unobs_or_zero_occ_residues.label_seq_id     203 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           32270039 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8ZWU 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8ZWZ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011726 
_atom_sites.fract_transf_matrix[1][2]   0.006770 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013540 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009422 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
MG 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . TYR A 1 1   ? 60.863 -11.427 -21.381 1.00 69.44  ? -5  TYR A N   1 
ATOM 2    C CA  . TYR A 1 1   ? 61.010 -11.868 -19.996 1.00 87.51  ? -5  TYR A CA  1 
ATOM 3    C C   . TYR A 1 1   ? 62.224 -11.247 -19.306 1.00 111.03 ? -5  TYR A C   1 
ATOM 4    O O   . TYR A 1 1   ? 63.351 -11.357 -19.787 1.00 123.92 ? -5  TYR A O   1 
ATOM 5    C CB  . TYR A 1 1   ? 61.106 -13.394 -19.931 1.00 95.86  ? -5  TYR A CB  1 
ATOM 6    C CG  . TYR A 1 1   ? 60.197 -14.030 -18.900 1.00 127.23 ? -5  TYR A CG  1 
ATOM 7    C CD1 . TYR A 1 1   ? 58.814 -13.972 -19.027 1.00 117.74 ? -5  TYR A CD1 1 
ATOM 8    C CD2 . TYR A 1 1   ? 60.726 -14.697 -17.802 1.00 115.84 ? -5  TYR A CD2 1 
ATOM 9    C CE1 . TYR A 1 1   ? 57.982 -14.560 -18.085 1.00 101.17 ? -5  TYR A CE1 1 
ATOM 10   C CE2 . TYR A 1 1   ? 59.906 -15.290 -16.857 1.00 107.93 ? -5  TYR A CE2 1 
ATOM 11   C CZ  . TYR A 1 1   ? 58.536 -15.218 -17.001 1.00 108.05 ? -5  TYR A CZ  1 
ATOM 12   O OH  . TYR A 1 1   ? 57.722 -15.806 -16.058 1.00 98.91  ? -5  TYR A OH  1 
ATOM 13   N N   . PHE A 1 2   ? 61.982 -10.589 -18.173 1.00 112.43 ? -4  PHE A N   1 
ATOM 14   C CA  . PHE A 1 2   ? 63.056 -10.056 -17.340 1.00 112.47 ? -4  PHE A CA  1 
ATOM 15   C C   . PHE A 1 2   ? 62.678 -10.198 -15.872 1.00 118.16 ? -4  PHE A C   1 
ATOM 16   O O   . PHE A 1 2   ? 61.965 -11.133 -15.505 1.00 118.76 ? -4  PHE A O   1 
ATOM 17   C CB  . PHE A 1 2   ? 63.379 -8.597  -17.697 1.00 106.59 ? -4  PHE A CB  1 
ATOM 18   C CG  . PHE A 1 2   ? 62.181 -7.682  -17.731 1.00 106.18 ? -4  PHE A CG  1 
ATOM 19   C CD1 . PHE A 1 2   ? 61.283 -7.734  -18.783 1.00 98.32  ? -4  PHE A CD1 1 
ATOM 20   C CD2 . PHE A 1 2   ? 61.965 -6.752  -16.725 1.00 110.86 ? -4  PHE A CD2 1 
ATOM 21   C CE1 . PHE A 1 2   ? 60.183 -6.887  -18.831 1.00 102.26 ? -4  PHE A CE1 1 
ATOM 22   C CE2 . PHE A 1 2   ? 60.864 -5.901  -16.767 1.00 104.51 ? -4  PHE A CE2 1 
ATOM 23   C CZ  . PHE A 1 2   ? 59.974 -5.971  -17.824 1.00 99.36  ? -4  PHE A CZ  1 
ATOM 24   N N   . GLN A 1 3   ? 63.150 -9.300  -15.011 1.00 116.30 ? -3  GLN A N   1 
ATOM 25   C CA  . GLN A 1 3   ? 62.811 -9.402  -13.593 1.00 104.58 ? -3  GLN A CA  1 
ATOM 26   C C   . GLN A 1 3   ? 61.417 -8.869  -13.271 1.00 114.28 ? -3  GLN A C   1 
ATOM 27   O O   . GLN A 1 3   ? 60.894 -9.157  -12.188 1.00 117.96 ? -3  GLN A O   1 
ATOM 28   C CB  . GLN A 1 3   ? 63.870 -8.691  -12.737 1.00 117.03 ? -3  GLN A CB  1 
ATOM 29   C CG  . GLN A 1 3   ? 63.741 -7.191  -12.685 1.00 130.49 ? -3  GLN A CG  1 
ATOM 30   C CD  . GLN A 1 3   ? 64.198 -6.546  -13.978 1.00 115.67 ? -3  GLN A CD  1 
ATOM 31   O OE1 . GLN A 1 3   ? 64.874 -7.177  -14.792 1.00 104.88 ? -3  GLN A OE1 1 
ATOM 32   N NE2 . GLN A 1 3   ? 63.824 -5.292  -14.180 1.00 99.59  ? -3  GLN A NE2 1 
ATOM 33   N N   . GLY A 1 4   ? 60.800 -8.115  -14.177 1.00 124.00 ? -2  GLY A N   1 
ATOM 34   C CA  . GLY A 1 4   ? 59.381 -7.833  -14.088 1.00 98.36  ? -2  GLY A CA  1 
ATOM 35   C C   . GLY A 1 4   ? 58.626 -8.820  -14.954 1.00 81.95  ? -2  GLY A C   1 
ATOM 36   O O   . GLY A 1 4   ? 58.048 -8.451  -15.981 1.00 77.04  ? -2  GLY A O   1 
ATOM 37   N N   . HIS A 1 5   ? 58.620 -10.084 -14.536 1.00 78.37  ? -1  HIS A N   1 
ATOM 38   C CA  . HIS A 1 5   ? 58.323 -11.203 -15.416 1.00 98.23  ? -1  HIS A CA  1 
ATOM 39   C C   . HIS A 1 5   ? 56.861 -11.640 -15.409 1.00 96.90  ? -1  HIS A C   1 
ATOM 40   O O   . HIS A 1 5   ? 56.560 -12.735 -15.894 1.00 106.77 ? -1  HIS A O   1 
ATOM 41   C CB  . HIS A 1 5   ? 59.245 -12.381 -15.078 1.00 102.60 ? -1  HIS A CB  1 
ATOM 42   C CG  . HIS A 1 5   ? 59.103 -12.899 -13.678 1.00 105.47 ? -1  HIS A CG  1 
ATOM 43   N ND1 . HIS A 1 5   ? 59.627 -12.240 -12.595 1.00 110.61 ? -1  HIS A ND1 1 
ATOM 44   C CD2 . HIS A 1 5   ? 58.508 -14.019 -13.193 1.00 106.63 ? -1  HIS A CD2 1 
ATOM 45   C CE1 . HIS A 1 5   ? 59.367 -12.927 -11.493 1.00 108.23 ? -1  HIS A CE1 1 
ATOM 46   N NE2 . HIS A 1 5   ? 58.687 -14.005 -11.829 1.00 99.77  ? -1  HIS A NE2 1 
ATOM 47   N N   . MET A 1 6   ? 55.945 -10.823 -14.891 1.00 74.61  ? 0   MET A N   1 
ATOM 48   C CA  . MET A 1 6   ? 54.540 -10.968 -15.274 1.00 59.95  ? 0   MET A CA  1 
ATOM 49   C C   . MET A 1 6   ? 54.313 -10.108 -16.514 1.00 67.22  ? 0   MET A C   1 
ATOM 50   O O   . MET A 1 6   ? 53.896 -8.952  -16.450 1.00 84.96  ? 0   MET A O   1 
ATOM 51   C CB  . MET A 1 6   ? 53.590 -10.616 -14.131 1.00 68.71  ? 0   MET A CB  1 
ATOM 52   C CG  . MET A 1 6   ? 52.122 -10.508 -14.582 1.00 76.16  ? 0   MET A CG  1 
ATOM 53   S SD  . MET A 1 6   ? 51.469 -11.940 -15.481 1.00 67.53  ? 0   MET A SD  1 
ATOM 54   C CE  . MET A 1 6   ? 50.569 -12.821 -14.228 1.00 44.99  ? 0   MET A CE  1 
ATOM 55   N N   . MET A 1 7   ? 54.655 -10.677 -17.667 1.00 51.35  ? 1   MET A N   1 
ATOM 56   C CA  . MET A 1 7   ? 54.382 -10.043 -18.949 1.00 48.12  ? 1   MET A CA  1 
ATOM 57   C C   . MET A 1 7   ? 53.149 -10.700 -19.551 1.00 36.71  ? 1   MET A C   1 
ATOM 58   O O   . MET A 1 7   ? 53.171 -11.893 -19.870 1.00 37.82  ? 1   MET A O   1 
ATOM 59   C CB  . MET A 1 7   ? 55.575 -10.174 -19.892 1.00 45.71  ? 1   MET A CB  1 
ATOM 60   C CG  . MET A 1 7   ? 56.866 -9.591  -19.350 1.00 51.90  ? 1   MET A CG  1 
ATOM 61   S SD  . MET A 1 7   ? 58.201 -9.628  -20.563 1.00 90.62  ? 1   MET A SD  1 
ATOM 62   C CE  . MET A 1 7   ? 57.401 -10.439 -21.952 1.00 59.42  ? 1   MET A CE  1 
ATOM 63   N N   . ILE A 1 8   ? 52.068 -9.935  -19.669 1.00 30.07  ? 2   ILE A N   1 
ATOM 64   C CA  . ILE A 1 8   ? 50.852 -10.409 -20.316 1.00 26.24  ? 2   ILE A CA  1 
ATOM 65   C C   . ILE A 1 8   ? 50.651 -9.613  -21.593 1.00 30.35  ? 2   ILE A C   1 
ATOM 66   O O   . ILE A 1 8   ? 51.463 -8.744  -21.927 1.00 31.78  ? 2   ILE A O   1 
ATOM 67   C CB  . ILE A 1 8   ? 49.635 -10.288 -19.385 1.00 28.25  ? 2   ILE A CB  1 
ATOM 68   C CG1 . ILE A 1 8   ? 49.606 -8.903  -18.739 1.00 30.34  ? 2   ILE A CG1 1 
ATOM 69   C CG2 . ILE A 1 8   ? 49.644 -11.392 -18.352 1.00 36.27  ? 2   ILE A CG2 1 
ATOM 70   C CD1 . ILE A 1 8   ? 48.511 -8.741  -17.729 1.00 33.49  ? 2   ILE A CD1 1 
ATOM 71   N N   . HIS A 1 9   ? 49.574 -9.900  -22.311 1.00 34.49  ? 3   HIS A N   1 
ATOM 72   C CA  . HIS A 1 9   ? 49.284 -9.217  -23.557 1.00 30.03  ? 3   HIS A CA  1 
ATOM 73   C C   . HIS A 1 9   ? 47.790 -8.961  -23.654 1.00 30.54  ? 3   HIS A C   1 
ATOM 74   O O   . HIS A 1 9   ? 46.981 -9.782  -23.214 1.00 27.98  ? 3   HIS A O   1 
ATOM 75   C CB  . HIS A 1 9   ? 49.764 -10.036 -24.760 1.00 25.77  ? 3   HIS A CB  1 
ATOM 76   C CG  . HIS A 1 9   ? 51.255 -10.158 -24.857 1.00 24.23  ? 3   HIS A CG  1 
ATOM 77   N ND1 . HIS A 1 9   ? 51.978 -11.094 -24.151 1.00 25.70  ? 3   HIS A ND1 1 
ATOM 78   C CD2 . HIS A 1 9   ? 52.157 -9.451  -25.579 1.00 32.78  ? 3   HIS A CD2 1 
ATOM 79   C CE1 . HIS A 1 9   ? 53.262 -10.963 -24.437 1.00 21.47  ? 3   HIS A CE1 1 
ATOM 80   N NE2 . HIS A 1 9   ? 53.397 -9.972  -25.299 1.00 20.25  ? 3   HIS A NE2 1 
ATOM 81   N N   . ALA A 1 10  ? 47.432 -7.814  -24.230 1.00 30.82  ? 4   ALA A N   1 
ATOM 82   C CA  . ALA A 1 10  ? 46.045 -7.447  -24.444 1.00 37.53  ? 4   ALA A CA  1 
ATOM 83   C C   . ALA A 1 10  ? 45.994 -6.463  -25.600 1.00 49.68  ? 4   ALA A C   1 
ATOM 84   O O   . ALA A 1 10  ? 46.880 -5.600  -25.703 1.00 59.76  ? 4   ALA A O   1 
ATOM 85   C CB  . ALA A 1 10  ? 45.417 -6.825  -23.194 1.00 29.65  ? 4   ALA A CB  1 
ATOM 86   N N   . PRO A 1 11  ? 45.003 -6.574  -26.488 1.00 39.97  ? 5   PRO A N   1 
ATOM 87   C CA  . PRO A 1 11  ? 44.913 -5.647  -27.620 1.00 41.31  ? 5   PRO A CA  1 
ATOM 88   C C   . PRO A 1 11  ? 44.914 -4.193  -27.169 1.00 55.69  ? 5   PRO A C   1 
ATOM 89   O O   . PRO A 1 11  ? 44.418 -3.848  -26.092 1.00 54.50  ? 5   PRO A O   1 
ATOM 90   C CB  . PRO A 1 11  ? 43.585 -6.025  -28.281 1.00 33.70  ? 5   PRO A CB  1 
ATOM 91   C CG  . PRO A 1 11  ? 43.442 -7.488  -27.995 1.00 30.08  ? 5   PRO A CG  1 
ATOM 92   C CD  . PRO A 1 11  ? 44.087 -7.720  -26.639 1.00 27.87  ? 5   PRO A CD  1 
ATOM 93   N N   . ARG A 1 12  ? 45.488 -3.339  -28.017 1.00 55.73  ? 6   ARG A N   1 
ATOM 94   C CA  . ARG A 1 12  ? 45.558 -1.911  -27.718 1.00 43.64  ? 6   ARG A CA  1 
ATOM 95   C C   . ARG A 1 12  ? 44.171 -1.294  -27.566 1.00 35.21  ? 6   ARG A C   1 
ATOM 96   O O   . ARG A 1 12  ? 43.940 -0.472  -26.668 1.00 37.44  ? 6   ARG A O   1 
ATOM 97   C CB  . ARG A 1 12  ? 46.343 -1.199  -28.818 1.00 49.82  ? 6   ARG A CB  1 
ATOM 98   C CG  . ARG A 1 12  ? 46.423 0.305   -28.693 1.00 77.89  ? 6   ARG A CG  1 
ATOM 99   C CD  . ARG A 1 12  ? 47.373 0.843   -29.744 1.00 86.89  ? 6   ARG A CD  1 
ATOM 100  N NE  . ARG A 1 12  ? 46.836 0.594   -31.076 1.00 79.25  ? 6   ARG A NE  1 
ATOM 101  C CZ  . ARG A 1 12  ? 47.500 0.795   -32.205 1.00 86.30  ? 6   ARG A CZ  1 
ATOM 102  N NH1 . ARG A 1 12  ? 48.670 1.420   -32.222 1.00 98.61  ? 6   ARG A NH1 1 
ATOM 103  N NH2 . ARG A 1 12  ? 46.971 0.375   -33.349 1.00 76.07  ? 6   ARG A NH2 1 
ATOM 104  N N   . ARG A 1 13  ? 43.237 -1.659  -28.446 1.00 35.81  ? 7   ARG A N   1 
ATOM 105  C CA  . ARG A 1 13  ? 41.906 -1.066  -28.375 1.00 34.62  ? 7   ARG A CA  1 
ATOM 106  C C   . ARG A 1 13  ? 41.156 -1.535  -27.133 1.00 50.17  ? 7   ARG A C   1 
ATOM 107  O O   . ARG A 1 13  ? 40.261 -0.833  -26.647 1.00 62.85  ? 7   ARG A O   1 
ATOM 108  C CB  . ARG A 1 13  ? 41.103 -1.382  -29.642 1.00 24.63  ? 7   ARG A CB  1 
ATOM 109  C CG  . ARG A 1 13  ? 40.815 -2.857  -29.879 1.00 42.66  ? 7   ARG A CG  1 
ATOM 110  C CD  . ARG A 1 13  ? 40.049 -3.049  -31.181 1.00 48.97  ? 7   ARG A CD  1 
ATOM 111  N NE  . ARG A 1 13  ? 39.559 -4.413  -31.358 1.00 68.58  ? 7   ARG A NE  1 
ATOM 112  C CZ  . ARG A 1 13  ? 38.384 -4.850  -30.923 1.00 65.87  ? 7   ARG A CZ  1 
ATOM 113  N NH1 . ARG A 1 13  ? 37.554 -4.059  -30.263 1.00 70.72  ? 7   ARG A NH1 1 
ATOM 114  N NH2 . ARG A 1 13  ? 38.030 -6.112  -31.162 1.00 47.16  ? 7   ARG A NH2 1 
ATOM 115  N N   . TRP A 1 14  ? 41.513 -2.707  -26.598 1.00 40.24  ? 8   TRP A N   1 
ATOM 116  C CA  . TRP A 1 14  ? 40.916 -3.162  -25.346 1.00 34.48  ? 8   TRP A CA  1 
ATOM 117  C C   . TRP A 1 14  ? 41.425 -2.349  -24.164 1.00 33.49  ? 8   TRP A C   1 
ATOM 118  O O   . TRP A 1 14  ? 40.652 -1.992  -23.268 1.00 41.32  ? 8   TRP A O   1 
ATOM 119  C CB  . TRP A 1 14  ? 41.204 -4.647  -25.119 1.00 39.25  ? 8   TRP A CB  1 
ATOM 120  C CG  . TRP A 1 14  ? 40.526 -5.581  -26.068 1.00 30.02  ? 8   TRP A CG  1 
ATOM 121  C CD1 . TRP A 1 14  ? 39.767 -5.247  -27.150 1.00 31.75  ? 8   TRP A CD1 1 
ATOM 122  C CD2 . TRP A 1 14  ? 40.504 -7.012  -25.986 1.00 29.44  ? 8   TRP A CD2 1 
ATOM 123  N NE1 . TRP A 1 14  ? 39.294 -6.384  -27.762 1.00 35.31  ? 8   TRP A NE1 1 
ATOM 124  C CE2 . TRP A 1 14  ? 39.728 -7.480  -27.063 1.00 28.23  ? 8   TRP A CE2 1 
ATOM 125  C CE3 . TRP A 1 14  ? 41.064 -7.942  -25.104 1.00 41.42  ? 8   TRP A CE3 1 
ATOM 126  C CZ2 . TRP A 1 14  ? 39.503 -8.836  -27.288 1.00 25.40  ? 8   TRP A CZ2 1 
ATOM 127  C CZ3 . TRP A 1 14  ? 40.844 -9.291  -25.332 1.00 34.24  ? 8   TRP A CZ3 1 
ATOM 128  C CH2 . TRP A 1 14  ? 40.070 -9.724  -26.415 1.00 22.04  ? 8   TRP A CH2 1 
ATOM 129  N N   . VAL A 1 15  ? 42.725 -2.049  -24.142 1.00 33.23  ? 9   VAL A N   1 
ATOM 130  C CA  . VAL A 1 15  ? 43.341 -1.437  -22.969 1.00 39.81  ? 9   VAL A CA  1 
ATOM 131  C C   . VAL A 1 15  ? 43.296 0.087   -22.981 1.00 34.46  ? 9   VAL A C   1 
ATOM 132  O O   . VAL A 1 15  ? 43.461 0.708   -21.922 1.00 53.83  ? 9   VAL A O   1 
ATOM 133  C CB  . VAL A 1 15  ? 44.805 -1.889  -22.815 1.00 44.13  ? 9   VAL A CB  1 
ATOM 134  C CG1 . VAL A 1 15  ? 44.867 -3.380  -22.580 1.00 39.84  ? 9   VAL A CG1 1 
ATOM 135  C CG2 . VAL A 1 15  ? 45.620 -1.512  -24.053 1.00 48.45  ? 9   VAL A CG2 1 
ATOM 136  N N   . GLU A 1 16  ? 43.107 0.712   -24.144 1.00 27.24  ? 10  GLU A N   1 
ATOM 137  C CA  . GLU A 1 16  ? 43.019 2.166   -24.163 1.00 33.60  ? 10  GLU A CA  1 
ATOM 138  C C   . GLU A 1 16  ? 41.781 2.673   -23.439 1.00 42.35  ? 10  GLU A C   1 
ATOM 139  O O   . GLU A 1 16  ? 41.728 3.857   -23.089 1.00 53.01  ? 10  GLU A O   1 
ATOM 140  C CB  . GLU A 1 16  ? 43.040 2.690   -25.598 1.00 45.16  ? 10  GLU A CB  1 
ATOM 141  C CG  . GLU A 1 16  ? 44.433 2.820   -26.178 1.00 60.32  ? 10  GLU A CG  1 
ATOM 142  C CD  . GLU A 1 16  ? 44.417 3.206   -27.641 1.00 86.49  ? 10  GLU A CD  1 
ATOM 143  O OE1 . GLU A 1 16  ? 43.330 3.154   -28.255 1.00 62.75  ? 10  GLU A OE1 1 
ATOM 144  O OE2 . GLU A 1 16  ? 45.482 3.592   -28.169 1.00 107.15 ? 10  GLU A OE2 1 
ATOM 145  N N   . ARG A 1 17  ? 40.788 1.810   -23.208 1.00 44.10  ? 11  ARG A N   1 
ATOM 146  C CA  . ARG A 1 17  ? 39.618 2.208   -22.440 1.00 47.39  ? 11  ARG A CA  1 
ATOM 147  C C   . ARG A 1 17  ? 39.847 2.178   -20.935 1.00 51.73  ? 11  ARG A C   1 
ATOM 148  O O   . ARG A 1 17  ? 39.012 2.704   -20.192 1.00 56.41  ? 11  ARG A O   1 
ATOM 149  C CB  . ARG A 1 17  ? 38.415 1.333   -22.797 1.00 39.21  ? 11  ARG A CB  1 
ATOM 150  C CG  . ARG A 1 17  ? 37.974 1.455   -24.242 1.00 27.54  ? 11  ARG A CG  1 
ATOM 151  C CD  . ARG A 1 17  ? 36.694 0.677   -24.495 1.00 43.94  ? 11  ARG A CD  1 
ATOM 152  N NE  . ARG A 1 17  ? 36.916 -0.763  -24.427 1.00 69.10  ? 11  ARG A NE  1 
ATOM 153  C CZ  . ARG A 1 17  ? 35.981 -1.660  -24.141 1.00 63.13  ? 11  ARG A CZ  1 
ATOM 154  N NH1 . ARG A 1 17  ? 34.733 -1.299  -23.878 1.00 34.81  ? 11  ARG A NH1 1 
ATOM 155  N NH2 . ARG A 1 17  ? 36.308 -2.953  -24.118 1.00 55.41  ? 11  ARG A NH2 1 
ATOM 156  N N   . HIS A 1 18  ? 40.944 1.586   -20.466 1.00 52.86  ? 12  HIS A N   1 
ATOM 157  C CA  . HIS A 1 18  ? 41.263 1.590   -19.044 1.00 47.52  ? 12  HIS A CA  1 
ATOM 158  C C   . HIS A 1 18  ? 42.219 2.715   -18.667 1.00 56.77  ? 12  HIS A C   1 
ATOM 159  O O   . HIS A 1 18  ? 42.443 2.945   -17.473 1.00 47.96  ? 12  HIS A O   1 
ATOM 160  C CB  . HIS A 1 18  ? 41.857 0.236   -18.633 1.00 43.75  ? 12  HIS A CB  1 
ATOM 161  C CG  . HIS A 1 18  ? 40.846 -0.866  -18.545 1.00 28.98  ? 12  HIS A CG  1 
ATOM 162  N ND1 . HIS A 1 18  ? 40.454 -1.611  -19.641 1.00 30.88  ? 12  HIS A ND1 1 
ATOM 163  C CD2 . HIS A 1 18  ? 40.155 -1.364  -17.493 1.00 29.78  ? 12  HIS A CD2 1 
ATOM 164  C CE1 . HIS A 1 18  ? 39.564 -2.508  -19.267 1.00 35.44  ? 12  HIS A CE1 1 
ATOM 165  N NE2 . HIS A 1 18  ? 39.362 -2.379  -17.966 1.00 28.44  ? 12  HIS A NE2 1 
ATOM 166  N N   . LYS A 1 19  ? 42.781 3.417   -19.657 1.00 61.68  ? 13  LYS A N   1 
ATOM 167  C CA  . LYS A 1 19  ? 43.582 4.620   -19.442 1.00 75.53  ? 13  LYS A CA  1 
ATOM 168  C C   . LYS A 1 19  ? 42.713 5.826   -19.114 1.00 86.37  ? 13  LYS A C   1 
ATOM 169  O O   . LYS A 1 19  ? 43.221 6.952   -19.024 1.00 79.96  ? 13  LYS A O   1 
ATOM 170  C CB  . LYS A 1 19  ? 44.428 4.910   -20.684 1.00 60.23  ? 13  LYS A CB  1 
ATOM 171  C CG  . LYS A 1 19  ? 45.377 3.781   -21.045 1.00 59.43  ? 13  LYS A CG  1 
ATOM 172  C CD  . LYS A 1 19  ? 46.043 4.045   -22.373 1.00 61.56  ? 13  LYS A CD  1 
ATOM 173  C CE  . LYS A 1 19  ? 46.859 2.848   -22.810 1.00 63.01  ? 13  LYS A CE  1 
ATOM 174  N NZ  . LYS A 1 19  ? 47.477 3.040   -24.149 1.00 67.75  ? 13  LYS A NZ  1 
ATOM 175  N N   . GLN A 1 20  ? 41.422 5.589   -18.912 1.00 80.38  ? 14  GLN A N   1 
ATOM 176  C CA  . GLN A 1 20  ? 40.352 6.574   -18.893 1.00 64.84  ? 14  GLN A CA  1 
ATOM 177  C C   . GLN A 1 20  ? 39.905 6.876   -17.473 1.00 84.32  ? 14  GLN A C   1 
ATOM 178  O O   . GLN A 1 20  ? 39.859 5.993   -16.612 1.00 87.78  ? 14  GLN A O   1 
ATOM 179  C CB  . GLN A 1 20  ? 39.176 6.048   -19.715 1.00 54.88  ? 14  GLN A CB  1 
ATOM 180  C CG  . GLN A 1 20  ? 39.542 5.827   -21.167 1.00 67.86  ? 14  GLN A CG  1 
ATOM 181  C CD  . GLN A 1 20  ? 38.428 5.197   -21.984 1.00 80.30  ? 14  GLN A CD  1 
ATOM 182  O OE1 . GLN A 1 20  ? 37.392 4.809   -21.454 1.00 82.34  ? 14  GLN A OE1 1 
ATOM 183  N NE2 . GLN A 1 20  ? 38.615 5.151   -23.290 1.00 74.27  ? 14  GLN A NE2 1 
ATOM 184  N N   . VAL A 1 21  ? 39.594 8.144   -17.234 1.00 98.93  ? 15  VAL A N   1 
ATOM 185  C CA  . VAL A 1 21  ? 39.128 8.598   -15.936 1.00 109.95 ? 15  VAL A CA  1 
ATOM 186  C C   . VAL A 1 21  ? 37.617 8.800   -15.984 1.00 93.50  ? 15  VAL A C   1 
ATOM 187  O O   . VAL A 1 21  ? 37.015 9.000   -17.044 1.00 94.38  ? 15  VAL A O   1 
ATOM 188  C CB  . VAL A 1 21  ? 39.841 9.893   -15.488 1.00 108.62 ? 15  VAL A CB  1 
ATOM 189  C CG1 . VAL A 1 21  ? 41.320 9.624   -15.272 1.00 113.32 ? 15  VAL A CG1 1 
ATOM 190  C CG2 . VAL A 1 21  ? 39.644 10.995  -16.518 1.00 108.98 ? 15  VAL A CG2 1 
ATOM 191  N N   . GLN A 1 22  ? 36.989 8.754   -14.810 1.00 81.46  ? 16  GLN A N   1 
ATOM 192  C CA  . GLN A 1 22  ? 35.537 8.890   -14.700 1.00 76.96  ? 16  GLN A CA  1 
ATOM 193  C C   . GLN A 1 22  ? 35.167 10.368  -14.745 1.00 82.62  ? 16  GLN A C   1 
ATOM 194  O O   . GLN A 1 22  ? 35.298 11.088  -13.753 1.00 82.57  ? 16  GLN A O   1 
ATOM 195  C CB  . GLN A 1 22  ? 35.027 8.230   -13.423 1.00 93.16  ? 16  GLN A CB  1 
ATOM 196  C CG  . GLN A 1 22  ? 33.506 8.221   -13.288 1.00 105.06 ? 16  GLN A CG  1 
ATOM 197  C CD  . GLN A 1 22  ? 32.803 7.634   -14.496 1.00 103.17 ? 16  GLN A CD  1 
ATOM 198  O OE1 . GLN A 1 22  ? 33.321 6.734   -15.162 1.00 82.04  ? 16  GLN A OE1 1 
ATOM 199  N NE2 . GLN A 1 22  ? 31.614 8.147   -14.789 1.00 94.34  ? 16  GLN A NE2 1 
ATOM 200  N N   . VAL A 1 23  ? 34.702 10.823  -15.908 1.00 88.62  ? 17  VAL A N   1 
ATOM 201  C CA  . VAL A 1 23  ? 34.179 12.174  -16.063 1.00 103.00 ? 17  VAL A CA  1 
ATOM 202  C C   . VAL A 1 23  ? 32.824 12.250  -15.375 1.00 94.70  ? 17  VAL A C   1 
ATOM 203  O O   . VAL A 1 23  ? 31.792 11.902  -15.962 1.00 106.86 ? 17  VAL A O   1 
ATOM 204  C CB  . VAL A 1 23  ? 34.075 12.572  -17.546 1.00 88.68  ? 17  VAL A CB  1 
ATOM 205  C CG1 . VAL A 1 23  ? 33.528 13.968  -17.668 1.00 76.60  ? 17  VAL A CG1 1 
ATOM 206  C CG2 . VAL A 1 23  ? 35.440 12.485  -18.210 1.00 80.87  ? 17  VAL A CG2 1 
ATOM 207  N N   . LEU A 1 24  ? 32.816 12.715  -14.135 1.00 70.01  ? 18  LEU A N   1 
ATOM 208  C CA  . LEU A 1 24  ? 31.586 12.698  -13.363 1.00 64.51  ? 18  LEU A CA  1 
ATOM 209  C C   . LEU A 1 24  ? 31.677 13.673  -12.195 1.00 72.48  ? 18  LEU A C   1 
ATOM 210  O O   . LEU A 1 24  ? 32.655 13.644  -11.439 1.00 64.14  ? 18  LEU A O   1 
ATOM 211  C CB  . LEU A 1 24  ? 31.311 11.281  -12.864 1.00 53.03  ? 18  LEU A CB  1 
ATOM 212  C CG  . LEU A 1 24  ? 29.890 10.930  -12.423 1.00 70.23  ? 18  LEU A CG  1 
ATOM 213  C CD1 . LEU A 1 24  ? 28.930 10.915  -13.607 1.00 50.00  ? 18  LEU A CD1 1 
ATOM 214  C CD2 . LEU A 1 24  ? 29.892 9.590   -11.704 1.00 75.25  ? 18  LEU A CD2 1 
ATOM 215  N N   . PRO A 1 25  ? 30.681 14.533  -12.004 1.00 71.73  ? 19  PRO A N   1 
ATOM 216  C CA  . PRO A 1 25  ? 30.731 15.481  -10.886 1.00 65.33  ? 19  PRO A CA  1 
ATOM 217  C C   . PRO A 1 25  ? 30.525 14.776  -9.557  1.00 78.66  ? 19  PRO A C   1 
ATOM 218  O O   . PRO A 1 25  ? 30.233 13.580  -9.485  1.00 78.35  ? 19  PRO A O   1 
ATOM 219  C CB  . PRO A 1 25  ? 29.585 16.448  -11.191 1.00 62.35  ? 19  PRO A CB  1 
ATOM 220  C CG  . PRO A 1 25  ? 28.605 15.599  -11.929 1.00 59.29  ? 19  PRO A CG  1 
ATOM 221  C CD  . PRO A 1 25  ? 29.429 14.655  -12.769 1.00 84.55  ? 19  PRO A CD  1 
ATOM 222  N N   . GLN A 1 26  ? 30.671 15.556  -8.484  1.00 84.48  ? 20  GLN A N   1 
ATOM 223  C CA  . GLN A 1 26  ? 30.632 15.009  -7.135  1.00 77.31  ? 20  GLN A CA  1 
ATOM 224  C C   . GLN A 1 26  ? 29.226 14.830  -6.601  1.00 76.08  ? 20  GLN A C   1 
ATOM 225  O O   . GLN A 1 26  ? 29.032 14.059  -5.655  1.00 76.03  ? 20  GLN A O   1 
ATOM 226  C CB  . GLN A 1 26  ? 31.422 15.897  -6.186  1.00 79.90  ? 20  GLN A CB  1 
ATOM 227  C CG  . GLN A 1 26  ? 32.864 15.972  -6.596  1.00 107.52 ? 20  GLN A CG  1 
ATOM 228  C CD  . GLN A 1 26  ? 33.457 14.604  -6.842  1.00 112.46 ? 20  GLN A CD  1 
ATOM 229  O OE1 . GLN A 1 26  ? 33.681 13.834  -5.904  1.00 117.23 ? 20  GLN A OE1 1 
ATOM 230  N NE2 . GLN A 1 26  ? 33.733 14.298  -8.106  1.00 99.64  ? 20  GLN A NE2 1 
ATOM 231  N N   . ASN A 1 27  ? 28.244 15.530  -7.168  1.00 69.20  ? 21  ASN A N   1 
ATOM 232  C CA  . ASN A 1 27  ? 26.863 15.175  -6.885  1.00 75.58  ? 21  ASN A CA  1 
ATOM 233  C C   . ASN A 1 27  ? 26.606 13.721  -7.255  1.00 76.41  ? 21  ASN A C   1 
ATOM 234  O O   . ASN A 1 27  ? 26.012 12.964  -6.480  1.00 72.13  ? 21  ASN A O   1 
ATOM 235  C CB  . ASN A 1 27  ? 25.913 16.109  -7.637  1.00 92.55  ? 21  ASN A CB  1 
ATOM 236  C CG  . ASN A 1 27  ? 26.064 17.562  -7.212  1.00 94.68  ? 21  ASN A CG  1 
ATOM 237  O OD1 . ASN A 1 27  ? 26.709 17.862  -6.205  1.00 98.99  ? 21  ASN A OD1 1 
ATOM 238  N ND2 . ASN A 1 27  ? 25.462 18.469  -7.972  1.00 98.62  ? 21  ASN A ND2 1 
ATOM 239  N N   . ALA A 1 28  ? 27.117 13.298  -8.413  1.00 72.45  ? 22  ALA A N   1 
ATOM 240  C CA  . ALA A 1 28  ? 26.870 11.970  -8.957  1.00 56.65  ? 22  ALA A CA  1 
ATOM 241  C C   . ALA A 1 28  ? 27.813 10.895  -8.425  1.00 55.14  ? 22  ALA A C   1 
ATOM 242  O O   . ALA A 1 28  ? 27.531 9.707   -8.611  1.00 48.84  ? 22  ALA A O   1 
ATOM 243  C CB  . ALA A 1 28  ? 26.958 12.011  -10.484 1.00 66.92  ? 22  ALA A CB  1 
ATOM 244  N N   . VAL A 1 29  ? 28.929 11.262  -7.792  1.00 66.40  ? 23  VAL A N   1 
ATOM 245  C CA  . VAL A 1 29  ? 29.716 10.243  -7.104  1.00 55.61  ? 23  VAL A CA  1 
ATOM 246  C C   . VAL A 1 29  ? 29.133 9.933   -5.733  1.00 52.62  ? 23  VAL A C   1 
ATOM 247  O O   . VAL A 1 29  ? 29.347 8.833   -5.211  1.00 52.44  ? 23  VAL A O   1 
ATOM 248  C CB  . VAL A 1 29  ? 31.195 10.644  -6.954  1.00 56.00  ? 23  VAL A CB  1 
ATOM 249  C CG1 . VAL A 1 29  ? 31.773 11.081  -8.291  1.00 47.35  ? 23  VAL A CG1 1 
ATOM 250  C CG2 . VAL A 1 29  ? 31.358 11.728  -5.903  1.00 87.56  ? 23  VAL A CG2 1 
ATOM 251  N N   . GLU A 1 30  ? 28.395 10.870  -5.139  1.00 55.52  ? 24  GLU A N   1 
ATOM 252  C CA  . GLU A 1 30  ? 27.747 10.625  -3.860  1.00 56.20  ? 24  GLU A CA  1 
ATOM 253  C C   . GLU A 1 30  ? 26.333 10.092  -4.034  1.00 52.00  ? 24  GLU A C   1 
ATOM 254  O O   . GLU A 1 30  ? 25.823 9.407   -3.140  1.00 56.15  ? 24  GLU A O   1 
ATOM 255  C CB  . GLU A 1 30  ? 27.735 11.906  -3.021  1.00 61.54  ? 24  GLU A CB  1 
ATOM 256  C CG  . GLU A 1 30  ? 29.121 12.340  -2.554  1.00 51.68  ? 24  GLU A CG  1 
ATOM 257  C CD  . GLU A 1 30  ? 29.826 11.274  -1.732  1.00 83.38  ? 24  GLU A CD  1 
ATOM 258  O OE1 . GLU A 1 30  ? 29.333 10.938  -0.636  1.00 116.55 ? 24  GLU A OE1 1 
ATOM 259  O OE2 . GLU A 1 30  ? 30.880 10.775  -2.183  1.00 78.12  ? 24  GLU A OE2 1 
ATOM 260  N N   . LYS A 1 31  ? 25.689 10.401  -5.162  1.00 44.20  ? 25  LYS A N   1 
ATOM 261  C CA  . LYS A 1 31  ? 24.525 9.630   -5.580  1.00 40.77  ? 25  LYS A CA  1 
ATOM 262  C C   . LYS A 1 31  ? 24.868 8.148   -5.638  1.00 44.51  ? 25  LYS A C   1 
ATOM 263  O O   . LYS A 1 31  ? 24.150 7.307   -5.087  1.00 37.33  ? 25  LYS A O   1 
ATOM 264  C CB  . LYS A 1 31  ? 24.033 10.111  -6.946  1.00 58.58  ? 25  LYS A CB  1 
ATOM 265  C CG  . LYS A 1 31  ? 23.221 11.394  -6.943  1.00 49.23  ? 25  LYS A CG  1 
ATOM 266  C CD  . LYS A 1 31  ? 22.438 11.503  -8.247  1.00 80.65  ? 25  LYS A CD  1 
ATOM 267  C CE  . LYS A 1 31  ? 21.553 12.737  -8.313  1.00 100.24 ? 25  LYS A CE  1 
ATOM 268  N NZ  . LYS A 1 31  ? 20.743 12.732  -9.567  1.00 71.85  ? 25  LYS A NZ  1 
ATOM 269  N N   . LEU A 1 32  ? 25.984 7.815   -6.291  1.00 45.51  ? 26  LEU A N   1 
ATOM 270  C CA  . LEU A 1 32  ? 26.351 6.418   -6.489  1.00 40.09  ? 26  LEU A CA  1 
ATOM 271  C C   . LEU A 1 32  ? 26.943 5.802   -5.228  1.00 43.02  ? 26  LEU A C   1 
ATOM 272  O O   . LEU A 1 32  ? 26.622 4.658   -4.887  1.00 39.09  ? 26  LEU A O   1 
ATOM 273  C CB  . LEU A 1 32  ? 27.322 6.299   -7.662  1.00 43.52  ? 26  LEU A CB  1 
ATOM 274  C CG  . LEU A 1 32  ? 26.726 6.711   -9.011  1.00 33.75  ? 26  LEU A CG  1 
ATOM 275  C CD1 . LEU A 1 32  ? 27.723 6.497   -10.138 1.00 33.18  ? 26  LEU A CD1 1 
ATOM 276  C CD2 . LEU A 1 32  ? 25.423 5.975   -9.280  1.00 43.11  ? 26  LEU A CD2 1 
ATOM 277  N N   . ILE A 1 33  ? 27.808 6.532   -4.527  1.00 49.99  ? 27  ILE A N   1 
ATOM 278  C CA  . ILE A 1 33  ? 28.324 6.089   -3.229  1.00 48.90  ? 27  ILE A CA  1 
ATOM 279  C C   . ILE A 1 33  ? 27.365 6.642   -2.181  1.00 61.76  ? 27  ILE A C   1 
ATOM 280  O O   . ILE A 1 33  ? 27.578 7.712   -1.611  1.00 69.30  ? 27  ILE A O   1 
ATOM 281  C CB  . ILE A 1 33  ? 29.760 6.546   -2.989  1.00 44.73  ? 27  ILE A CB  1 
ATOM 282  C CG1 . ILE A 1 33  ? 30.668 6.146   -4.151  1.00 37.77  ? 27  ILE A CG1 1 
ATOM 283  C CG2 . ILE A 1 33  ? 30.300 5.962   -1.686  1.00 51.01  ? 27  ILE A CG2 1 
ATOM 284  C CD1 . ILE A 1 33  ? 31.912 7.007   -4.259  1.00 46.35  ? 27  ILE A CD1 1 
ATOM 285  N N   . SER A 1 34  ? 26.282 5.908   -1.932  1.00 51.78  ? 28  SER A N   1 
ATOM 286  C CA  . SER A 1 34  ? 25.350 6.277   -0.869  1.00 57.93  ? 28  SER A CA  1 
ATOM 287  C C   . SER A 1 34  ? 25.825 5.594   0.408   1.00 63.74  ? 28  SER A C   1 
ATOM 288  O O   . SER A 1 34  ? 25.329 4.541   0.819   1.00 64.70  ? 28  SER A O   1 
ATOM 289  C CB  . SER A 1 34  ? 23.925 5.891   -1.233  1.00 66.16  ? 28  SER A CB  1 
ATOM 290  O OG  . SER A 1 34  ? 23.419 6.729   -2.256  1.00 46.50  ? 28  SER A OG  1 
ATOM 291  N N   . MET A 1 35  ? 26.824 6.216   1.039   1.00 54.20  ? 29  MET A N   1 
ATOM 292  C CA  . MET A 1 35  ? 27.448 5.609   2.213   1.00 54.63  ? 29  MET A CA  1 
ATOM 293  C C   . MET A 1 35  ? 26.471 5.535   3.382   1.00 50.85  ? 29  MET A C   1 
ATOM 294  O O   . MET A 1 35  ? 26.466 4.558   4.144   1.00 48.79  ? 29  MET A O   1 
ATOM 295  C CB  . MET A 1 35  ? 28.696 6.395   2.609   1.00 57.97  ? 29  MET A CB  1 
ATOM 296  C CG  . MET A 1 35  ? 29.373 5.895   3.866   1.00 66.10  ? 29  MET A CG  1 
ATOM 297  S SD  . MET A 1 35  ? 29.863 4.165   3.740   1.00 39.30  ? 29  MET A SD  1 
ATOM 298  C CE  . MET A 1 35  ? 31.098 4.245   2.442   1.00 36.95  ? 29  MET A CE  1 
ATOM 299  N N   . ASN A 1 36  ? 25.626 6.557   3.534   1.00 55.12  ? 30  ASN A N   1 
ATOM 300  C CA  . ASN A 1 36  ? 24.616 6.528   4.586   1.00 53.26  ? 30  ASN A CA  1 
ATOM 301  C C   . ASN A 1 36  ? 23.639 5.382   4.366   1.00 51.67  ? 30  ASN A C   1 
ATOM 302  O O   . ASN A 1 36  ? 23.226 4.711   5.320   1.00 53.42  ? 30  ASN A O   1 
ATOM 303  C CB  . ASN A 1 36  ? 23.870 7.863   4.644   1.00 68.75  ? 30  ASN A CB  1 
ATOM 304  C CG  . ASN A 1 36  ? 24.777 9.021   5.023   1.00 74.45  ? 30  ASN A CG  1 
ATOM 305  O OD1 . ASN A 1 36  ? 25.900 8.819   5.492   1.00 63.38  ? 30  ASN A OD1 1 
ATOM 306  N ND2 . ASN A 1 36  ? 24.291 10.242  4.827   1.00 76.24  ? 30  ASN A ND2 1 
ATOM 307  N N   . GLU A 1 37  ? 23.265 5.141   3.107   1.00 41.00  ? 31  GLU A N   1 
ATOM 308  C CA  . GLU A 1 37  ? 22.369 4.031   2.803   1.00 42.55  ? 31  GLU A CA  1 
ATOM 309  C C   . GLU A 1 37  ? 23.043 2.693   3.071   1.00 41.49  ? 31  GLU A C   1 
ATOM 310  O O   . GLU A 1 37  ? 22.393 1.748   3.524   1.00 44.63  ? 31  GLU A O   1 
ATOM 311  C CB  . GLU A 1 37  ? 21.888 4.105   1.353   1.00 41.03  ? 31  GLU A CB  1 
ATOM 312  C CG  . GLU A 1 37  ? 20.901 5.231   1.077   1.00 62.00  ? 31  GLU A CG  1 
ATOM 313  C CD  . GLU A 1 37  ? 20.369 5.206   -0.342  1.00 93.04  ? 31  GLU A CD  1 
ATOM 314  O OE1 . GLU A 1 37  ? 19.855 4.148   -0.763  1.00 96.49  ? 31  GLU A OE1 1 
ATOM 315  O OE2 . GLU A 1 37  ? 20.464 6.241   -1.037  1.00 84.96  ? 31  GLU A OE2 1 
ATOM 316  N N   . LEU A 1 38  ? 24.350 2.596   2.818   1.00 35.30  ? 32  LEU A N   1 
ATOM 317  C CA  . LEU A 1 38  ? 25.071 1.368   3.148   1.00 36.05  ? 32  LEU A CA  1 
ATOM 318  C C   . LEU A 1 38  ? 25.104 1.134   4.654   1.00 38.26  ? 32  LEU A C   1 
ATOM 319  O O   . LEU A 1 38  ? 24.920 0.002   5.124   1.00 40.04  ? 32  LEU A O   1 
ATOM 320  C CB  . LEU A 1 38  ? 26.492 1.427   2.588   1.00 24.89  ? 32  LEU A CB  1 
ATOM 321  C CG  . LEU A 1 38  ? 27.390 0.215   2.839   1.00 18.36  ? 32  LEU A CG  1 
ATOM 322  C CD1 . LEU A 1 38  ? 26.772 -1.039  2.256   1.00 18.46  ? 32  LEU A CD1 1 
ATOM 323  C CD2 . LEU A 1 38  ? 28.755 0.461   2.229   1.00 10.82  ? 32  LEU A CD2 1 
ATOM 324  N N   . ILE A 1 39  ? 25.344 2.197   5.424   1.00 40.76  ? 33  ILE A N   1 
ATOM 325  C CA  . ILE A 1 39  ? 25.317 2.106   6.880   1.00 50.29  ? 33  ILE A CA  1 
ATOM 326  C C   . ILE A 1 39  ? 23.960 1.598   7.353   1.00 56.13  ? 33  ILE A C   1 
ATOM 327  O O   . ILE A 1 39  ? 23.867 0.624   8.112   1.00 58.71  ? 33  ILE A O   1 
ATOM 328  C CB  . ILE A 1 39  ? 25.649 3.475   7.501   1.00 48.30  ? 33  ILE A CB  1 
ATOM 329  C CG1 . ILE A 1 39  ? 27.141 3.776   7.358   1.00 44.92  ? 33  ILE A CG1 1 
ATOM 330  C CG2 . ILE A 1 39  ? 25.244 3.513   8.968   1.00 58.39  ? 33  ILE A CG2 1 
ATOM 331  C CD1 . ILE A 1 39  ? 27.487 5.240   7.497   1.00 65.97  ? 33  ILE A CD1 1 
ATOM 332  N N   . GLU A 1 40  ? 22.890 2.267   6.913   1.00 40.25  ? 34  GLU A N   1 
ATOM 333  C CA  . GLU A 1 40  ? 21.544 1.890   7.334   1.00 46.23  ? 34  GLU A CA  1 
ATOM 334  C C   . GLU A 1 40  ? 21.193 0.482   6.874   1.00 59.93  ? 34  GLU A C   1 
ATOM 335  O O   . GLU A 1 40  ? 20.438 -0.226  7.547   1.00 72.67  ? 34  GLU A O   1 
ATOM 336  C CB  . GLU A 1 40  ? 20.521 2.889   6.792   1.00 55.04  ? 34  GLU A CB  1 
ATOM 337  C CG  . GLU A 1 40  ? 20.575 4.261   7.431   1.00 58.39  ? 34  GLU A CG  1 
ATOM 338  C CD  . GLU A 1 40  ? 19.804 5.293   6.632   1.00 77.08  ? 34  GLU A CD  1 
ATOM 339  O OE1 . GLU A 1 40  ? 19.209 4.922   5.597   1.00 68.14  ? 34  GLU A OE1 1 
ATOM 340  O OE2 . GLU A 1 40  ? 19.801 6.475   7.034   1.00 83.33  ? 34  GLU A OE2 1 
ATOM 341  N N   . LEU A 1 41  ? 21.735 0.054   5.732   1.00 56.67  ? 35  LEU A N   1 
ATOM 342  C CA  . LEU A 1 41  ? 21.426 -1.273  5.218   1.00 50.57  ? 35  LEU A CA  1 
ATOM 343  C C   . LEU A 1 41  ? 22.112 -2.355  6.039   1.00 53.95  ? 35  LEU A C   1 
ATOM 344  O O   . LEU A 1 41  ? 21.499 -3.380  6.355   1.00 66.67  ? 35  LEU A O   1 
ATOM 345  C CB  . LEU A 1 41  ? 21.843 -1.369  3.751   1.00 38.26  ? 35  LEU A CB  1 
ATOM 346  C CG  . LEU A 1 41  ? 21.602 -2.693  3.028   1.00 57.52  ? 35  LEU A CG  1 
ATOM 347  C CD1 . LEU A 1 41  ? 20.143 -3.118  3.138   1.00 67.78  ? 35  LEU A CD1 1 
ATOM 348  C CD2 . LEU A 1 41  ? 22.047 -2.594  1.572   1.00 50.53  ? 35  LEU A CD2 1 
ATOM 349  N N   . VAL A 1 42  ? 23.384 -2.151  6.388   1.00 48.19  ? 36  VAL A N   1 
ATOM 350  C CA  . VAL A 1 42  ? 24.101 -3.181  7.135   1.00 47.23  ? 36  VAL A CA  1 
ATOM 351  C C   . VAL A 1 42  ? 23.726 -3.187  8.613   1.00 57.08  ? 36  VAL A C   1 
ATOM 352  O O   . VAL A 1 42  ? 23.927 -4.207  9.285   1.00 53.03  ? 36  VAL A O   1 
ATOM 353  C CB  . VAL A 1 42  ? 25.624 -3.031  6.982   1.00 38.14  ? 36  VAL A CB  1 
ATOM 354  C CG1 . VAL A 1 42  ? 26.026 -3.160  5.517   1.00 29.83  ? 36  VAL A CG1 1 
ATOM 355  C CG2 . VAL A 1 42  ? 26.101 -1.715  7.568   1.00 57.46  ? 36  VAL A CG2 1 
ATOM 356  N N   . ILE A 1 43  ? 23.187 -2.084  9.148   1.00 61.24  ? 37  ILE A N   1 
ATOM 357  C CA  . ILE A 1 43  ? 22.658 -2.111  10.510  1.00 64.72  ? 37  ILE A CA  1 
ATOM 358  C C   . ILE A 1 43  ? 21.163 -2.415  10.549  1.00 55.38  ? 37  ILE A C   1 
ATOM 359  O O   . ILE A 1 43  ? 20.620 -2.642  11.641  1.00 52.22  ? 37  ILE A O   1 
ATOM 360  C CB  . ILE A 1 43  ? 22.951 -0.803  11.281  1.00 71.45  ? 37  ILE A CB  1 
ATOM 361  C CG1 . ILE A 1 43  ? 22.144 0.373   10.725  1.00 69.45  ? 37  ILE A CG1 1 
ATOM 362  C CG2 . ILE A 1 43  ? 24.450 -0.498  11.283  1.00 56.08  ? 37  ILE A CG2 1 
ATOM 363  C CD1 . ILE A 1 43  ? 22.583 1.717   11.286  1.00 60.70  ? 37  ILE A CD1 1 
ATOM 364  N N   . GLU A 1 44  ? 20.481 -2.428  9.401   1.00 59.56  ? 38  GLU A N   1 
ATOM 365  C CA  . GLU A 1 44  ? 19.119 -2.948  9.343   1.00 55.41  ? 38  GLU A CA  1 
ATOM 366  C C   . GLU A 1 44  ? 19.131 -4.465  9.209   1.00 49.95  ? 38  GLU A C   1 
ATOM 367  O O   . GLU A 1 44  ? 18.271 -5.152  9.771   1.00 60.54  ? 38  GLU A O   1 
ATOM 368  C CB  . GLU A 1 44  ? 18.363 -2.297  8.183   1.00 76.08  ? 38  GLU A CB  1 
ATOM 369  C CG  . GLU A 1 44  ? 16.946 -2.824  7.962   1.00 81.78  ? 38  GLU A CG  1 
ATOM 370  C CD  . GLU A 1 44  ? 16.213 -2.088  6.853   1.00 101.57 ? 38  GLU A CD  1 
ATOM 371  O OE1 . GLU A 1 44  ? 16.837 -1.217  6.215   1.00 113.21 ? 38  GLU A OE1 1 
ATOM 372  O OE2 . GLU A 1 44  ? 15.019 -2.377  6.621   1.00 73.81  ? 38  GLU A OE2 1 
ATOM 373  N N   . CYS A 1 45  ? 20.105 -4.993  8.473   1.00 61.25  ? 39  CYS A N   1 
ATOM 374  C CA  . CYS A 1 45  ? 20.481 -6.392  8.558   1.00 49.13  ? 39  CYS A CA  1 
ATOM 375  C C   . CYS A 1 45  ? 21.330 -6.591  9.811   1.00 54.10  ? 39  CYS A C   1 
ATOM 376  O O   . CYS A 1 45  ? 21.629 -5.644  10.545  1.00 64.24  ? 39  CYS A O   1 
ATOM 377  C CB  . CYS A 1 45  ? 21.241 -6.816  7.302   1.00 61.60  ? 39  CYS A CB  1 
ATOM 378  S SG  . CYS A 1 45  ? 20.313 -6.654  5.762   1.00 54.66  ? 39  CYS A SG  1 
ATOM 379  N N   . GLY A 1 46  ? 21.732 -7.831  10.068  1.00 64.31  ? 40  GLY A N   1 
ATOM 380  C CA  . GLY A 1 46  ? 22.573 -8.141  11.204  1.00 80.14  ? 40  GLY A CA  1 
ATOM 381  C C   . GLY A 1 46  ? 24.046 -8.268  10.889  1.00 65.73  ? 40  GLY A C   1 
ATOM 382  O O   . GLY A 1 46  ? 24.793 -8.812  11.712  1.00 80.04  ? 40  GLY A O   1 
ATOM 383  N N   . LEU A 1 47  ? 24.492 -7.779  9.732   1.00 62.62  ? 41  LEU A N   1 
ATOM 384  C CA  . LEU A 1 47  ? 25.855 -7.995  9.263   1.00 67.70  ? 41  LEU A CA  1 
ATOM 385  C C   . LEU A 1 47  ? 26.899 -7.414  10.209  1.00 74.36  ? 41  LEU A C   1 
ATOM 386  O O   . LEU A 1 47  ? 27.516 -8.149  10.987  1.00 69.90  ? 41  LEU A O   1 
ATOM 387  C CB  . LEU A 1 47  ? 26.035 -7.398  7.865   1.00 55.86  ? 41  LEU A CB  1 
ATOM 388  C CG  . LEU A 1 47  ? 25.335 -8.111  6.706   1.00 66.60  ? 41  LEU A CG  1 
ATOM 389  C CD1 . LEU A 1 47  ? 25.333 -7.227  5.469   1.00 76.74  ? 41  LEU A CD1 1 
ATOM 390  C CD2 . LEU A 1 47  ? 26.003 -9.448  6.411   1.00 48.02  ? 41  LEU A CD2 1 
ATOM 391  N N   . CYS A 1 48  ? 27.105 -6.103  10.148  1.00 72.67  ? 42  CYS A N   1 
ATOM 392  C CA  . CYS A 1 48  ? 28.203 -5.470  10.865  1.00 75.99  ? 42  CYS A CA  1 
ATOM 393  C C   . CYS A 1 48  ? 27.796 -4.045  11.217  1.00 66.88  ? 42  CYS A C   1 
ATOM 394  O O   . CYS A 1 48  ? 26.638 -3.651  11.049  1.00 49.22  ? 42  CYS A O   1 
ATOM 395  C CB  . CYS A 1 48  ? 29.478 -5.503  10.017  1.00 72.68  ? 42  CYS A CB  1 
ATOM 396  S SG  . CYS A 1 48  ? 29.299 -4.618  8.459   1.00 45.73  ? 42  CYS A SG  1 
ATOM 397  N N   . ASP A 1 49  ? 28.758 -3.267  11.702  1.00 73.72  ? 43  ASP A N   1 
ATOM 398  C CA  . ASP A 1 49  ? 28.537 -1.895  12.134  1.00 67.83  ? 43  ASP A CA  1 
ATOM 399  C C   . ASP A 1 49  ? 29.193 -0.932  11.150  1.00 60.14  ? 43  ASP A C   1 
ATOM 400  O O   . ASP A 1 49  ? 29.744 -1.334  10.122  1.00 55.86  ? 43  ASP A O   1 
ATOM 401  C CB  . ASP A 1 49  ? 29.066 -1.683  13.556  1.00 82.05  ? 43  ASP A CB  1 
ATOM 402  C CG  . ASP A 1 49  ? 30.580 -1.601  13.607  1.00 99.64  ? 43  ASP A CG  1 
ATOM 403  O OD1 . ASP A 1 49  ? 31.248 -2.323  12.832  1.00 90.79  ? 43  ASP A OD1 1 
ATOM 404  O OD2 . ASP A 1 49  ? 31.103 -0.809  14.419  1.00 102.39 ? 43  ASP A OD2 1 
ATOM 405  N N   . LYS A 1 50  ? 29.142 0.359   11.491  1.00 36.09  ? 44  LYS A N   1 
ATOM 406  C CA  . LYS A 1 50  ? 29.648 1.395   10.592  1.00 47.80  ? 44  LYS A CA  1 
ATOM 407  C C   . LYS A 1 50  ? 31.153 1.269   10.391  1.00 64.21  ? 44  LYS A C   1 
ATOM 408  O O   . LYS A 1 50  ? 31.659 1.437   9.273   1.00 64.60  ? 44  LYS A O   1 
ATOM 409  C CB  . LYS A 1 50  ? 29.301 2.771   11.156  1.00 39.10  ? 44  LYS A CB  1 
ATOM 410  C CG  . LYS A 1 50  ? 27.868 2.874   11.637  1.00 51.33  ? 44  LYS A CG  1 
ATOM 411  C CD  . LYS A 1 50  ? 27.437 4.312   11.849  1.00 53.86  ? 44  LYS A CD  1 
ATOM 412  C CE  . LYS A 1 50  ? 26.012 4.370   12.383  1.00 94.08  ? 44  LYS A CE  1 
ATOM 413  N NZ  . LYS A 1 50  ? 25.524 5.766   12.555  1.00 61.63  ? 44  LYS A NZ  1 
ATOM 414  N N   . THR A 1 51  ? 31.882 0.979   11.470  1.00 50.36  ? 45  THR A N   1 
ATOM 415  C CA  . THR A 1 51  ? 33.332 0.850   11.388  1.00 53.92  ? 45  THR A CA  1 
ATOM 416  C C   . THR A 1 51  ? 33.739 -0.257  10.423  1.00 67.99  ? 45  THR A C   1 
ATOM 417  O O   . THR A 1 51  ? 34.700 -0.104  9.662   1.00 83.73  ? 45  THR A O   1 
ATOM 418  C CB  . THR A 1 51  ? 33.907 0.584   12.779  1.00 56.78  ? 45  THR A CB  1 
ATOM 419  O OG1 . THR A 1 51  ? 33.287 1.460   13.730  1.00 71.43  ? 45  THR A OG1 1 
ATOM 420  C CG2 . THR A 1 51  ? 35.403 0.817   12.783  1.00 69.43  ? 45  THR A CG2 1 
ATOM 421  N N   . SER A 1 52  ? 33.014 -1.376  10.429  1.00 51.37  ? 46  SER A N   1 
ATOM 422  C CA  . SER A 1 52  ? 33.406 -2.507  9.593   1.00 46.25  ? 46  SER A CA  1 
ATOM 423  C C   . SER A 1 52  ? 33.245 -2.189  8.111   1.00 48.06  ? 46  SER A C   1 
ATOM 424  O O   . SER A 1 52  ? 34.148 -2.459  7.309   1.00 52.81  ? 46  SER A O   1 
ATOM 425  C CB  . SER A 1 52  ? 32.601 -3.746  9.978   1.00 52.48  ? 46  SER A CB  1 
ATOM 426  O OG  . SER A 1 52  ? 32.901 -4.134  11.305  1.00 65.85  ? 46  SER A OG  1 
ATOM 427  N N   . ILE A 1 53  ? 32.104 -1.614  7.721   1.00 56.79  ? 47  ILE A N   1 
ATOM 428  C CA  . ILE A 1 53  ? 31.922 -1.279  6.313   1.00 55.03  ? 47  ILE A CA  1 
ATOM 429  C C   . ILE A 1 53  ? 32.864 -0.161  5.894   1.00 57.96  ? 47  ILE A C   1 
ATOM 430  O O   . ILE A 1 53  ? 33.335 -0.144  4.753   1.00 62.58  ? 47  ILE A O   1 
ATOM 431  C CB  . ILE A 1 53  ? 30.461 -0.909  6.004   1.00 34.06  ? 47  ILE A CB  1 
ATOM 432  C CG1 . ILE A 1 53  ? 29.954 0.126   7.002   1.00 50.14  ? 47  ILE A CG1 1 
ATOM 433  C CG2 . ILE A 1 53  ? 29.589 -2.145  5.996   1.00 27.95  ? 47  ILE A CG2 1 
ATOM 434  C CD1 . ILE A 1 53  ? 28.597 0.646   6.670   1.00 41.79  ? 47  ILE A CD1 1 
ATOM 435  N N   . LYS A 1 54  ? 33.165 0.787   6.788   1.00 52.98  ? 48  LYS A N   1 
ATOM 436  C CA  . LYS A 1 54  ? 34.111 1.836   6.413   1.00 57.69  ? 48  LYS A CA  1 
ATOM 437  C C   . LYS A 1 54  ? 35.519 1.277   6.239   1.00 49.23  ? 48  LYS A C   1 
ATOM 438  O O   . LYS A 1 54  ? 36.257 1.703   5.341   1.00 49.71  ? 48  LYS A O   1 
ATOM 439  C CB  . LYS A 1 54  ? 34.088 2.966   7.440   1.00 64.44  ? 48  LYS A CB  1 
ATOM 440  C CG  . LYS A 1 54  ? 32.830 3.815   7.356   1.00 55.01  ? 48  LYS A CG  1 
ATOM 441  C CD  . LYS A 1 54  ? 32.775 4.859   8.453   1.00 68.53  ? 48  LYS A CD  1 
ATOM 442  C CE  . LYS A 1 54  ? 31.467 5.632   8.396   1.00 48.32  ? 48  LYS A CE  1 
ATOM 443  N NZ  . LYS A 1 54  ? 31.399 6.705   9.426   1.00 60.42  ? 48  LYS A NZ  1 
ATOM 444  N N   . LYS A 1 55  ? 35.899 0.303   7.064   1.00 42.71  ? 49  LYS A N   1 
ATOM 445  C CA  . LYS A 1 55  ? 37.198 -0.337  6.896   1.00 51.23  ? 49  LYS A CA  1 
ATOM 446  C C   . LYS A 1 55  ? 37.254 -1.140  5.603   1.00 54.62  ? 49  LYS A C   1 
ATOM 447  O O   . LYS A 1 55  ? 38.253 -1.085  4.876   1.00 69.38  ? 49  LYS A O   1 
ATOM 448  C CB  . LYS A 1 55  ? 37.505 -1.219  8.108   1.00 56.97  ? 49  LYS A CB  1 
ATOM 449  C CG  . LYS A 1 55  ? 37.918 -0.430  9.345   1.00 65.26  ? 49  LYS A CG  1 
ATOM 450  C CD  . LYS A 1 55  ? 38.094 -1.328  10.561  1.00 55.28  ? 49  LYS A CD  1 
ATOM 451  C CE  . LYS A 1 55  ? 38.649 -0.548  11.744  1.00 59.10  ? 49  LYS A CE  1 
ATOM 452  N NZ  . LYS A 1 55  ? 38.728 -1.387  12.970  1.00 95.17  ? 49  LYS A NZ  1 
ATOM 453  N N   . MET A 1 56  ? 36.188 -1.881  5.288   1.00 48.20  ? 50  MET A N   1 
ATOM 454  C CA  . MET A 1 56  ? 36.142 -2.604  4.019   1.00 47.87  ? 50  MET A CA  1 
ATOM 455  C C   . MET A 1 56  ? 36.184 -1.649  2.834   1.00 55.29  ? 50  MET A C   1 
ATOM 456  O O   . MET A 1 56  ? 36.796 -1.952  1.802   1.00 60.91  ? 50  MET A O   1 
ATOM 457  C CB  . MET A 1 56  ? 34.895 -3.488  3.947   1.00 28.74  ? 50  MET A CB  1 
ATOM 458  C CG  . MET A 1 56  ? 34.946 -4.711  4.840   1.00 62.28  ? 50  MET A CG  1 
ATOM 459  S SD  . MET A 1 56  ? 36.355 -5.755  4.419   1.00 81.30  ? 50  MET A SD  1 
ATOM 460  C CE  . MET A 1 56  ? 35.986 -6.147  2.708   1.00 32.11  ? 50  MET A CE  1 
ATOM 461  N N   . TYR A 1 57  ? 35.545 -0.485  2.965   1.00 57.14  ? 51  TYR A N   1 
ATOM 462  C CA  . TYR A 1 57  ? 35.527 0.481   1.873   1.00 52.55  ? 51  TYR A CA  1 
ATOM 463  C C   . TYR A 1 57  ? 36.907 1.094   1.664   1.00 53.96  ? 51  TYR A C   1 
ATOM 464  O O   . TYR A 1 57  ? 37.334 1.305   0.523   1.00 66.20  ? 51  TYR A O   1 
ATOM 465  C CB  . TYR A 1 57  ? 34.482 1.563   2.159   1.00 38.39  ? 51  TYR A CB  1 
ATOM 466  C CG  . TYR A 1 57  ? 34.299 2.572   1.048   1.00 34.84  ? 51  TYR A CG  1 
ATOM 467  C CD1 . TYR A 1 57  ? 35.104 3.700   0.962   1.00 63.43  ? 51  TYR A CD1 1 
ATOM 468  C CD2 . TYR A 1 57  ? 33.309 2.401   0.093   1.00 33.43  ? 51  TYR A CD2 1 
ATOM 469  C CE1 . TYR A 1 57  ? 34.933 4.620   -0.058  1.00 73.77  ? 51  TYR A CE1 1 
ATOM 470  C CE2 . TYR A 1 57  ? 33.128 3.315   -0.926  1.00 46.90  ? 51  TYR A CE2 1 
ATOM 471  C CZ  . TYR A 1 57  ? 33.943 4.422   -0.997  1.00 64.89  ? 51  TYR A CZ  1 
ATOM 472  O OH  . TYR A 1 57  ? 33.762 5.332   -2.012  1.00 70.99  ? 51  TYR A OH  1 
ATOM 473  N N   . ASP A 1 58  ? 37.622 1.382   2.755   1.00 50.17  ? 52  ASP A N   1 
ATOM 474  C CA  . ASP A 1 58  ? 38.989 1.881   2.626   1.00 52.22  ? 52  ASP A CA  1 
ATOM 475  C C   . ASP A 1 58  ? 39.912 0.816   2.047   1.00 56.13  ? 52  ASP A C   1 
ATOM 476  O O   . ASP A 1 58  ? 40.792 1.123   1.235   1.00 66.75  ? 52  ASP A O   1 
ATOM 477  C CB  . ASP A 1 58  ? 39.514 2.350   3.983   1.00 80.68  ? 52  ASP A CB  1 
ATOM 478  C CG  . ASP A 1 58  ? 38.815 3.595   4.480   1.00 93.75  ? 52  ASP A CG  1 
ATOM 479  O OD1 . ASP A 1 58  ? 38.053 4.203   3.696   1.00 87.63  ? 52  ASP A OD1 1 
ATOM 480  O OD2 . ASP A 1 58  ? 39.034 3.968   5.652   1.00 100.32 ? 52  ASP A OD2 1 
ATOM 481  N N   . LYS A 1 59  ? 39.729 -0.440  2.459   1.00 45.03  ? 53  LYS A N   1 
ATOM 482  C CA  . LYS A 1 59  ? 40.583 -1.515  1.968   1.00 57.26  ? 53  LYS A CA  1 
ATOM 483  C C   . LYS A 1 59  ? 40.382 -1.733  0.475   1.00 58.70  ? 53  LYS A C   1 
ATOM 484  O O   . LYS A 1 59  ? 41.336 -1.681  -0.309  1.00 58.58  ? 53  LYS A O   1 
ATOM 485  C CB  . LYS A 1 59  ? 40.287 -2.807  2.731   1.00 46.94  ? 53  LYS A CB  1 
ATOM 486  C CG  . LYS A 1 59  ? 40.819 -2.851  4.151   1.00 59.31  ? 53  LYS A CG  1 
ATOM 487  C CD  . LYS A 1 59  ? 40.173 -3.996  4.923   1.00 70.56  ? 53  LYS A CD  1 
ATOM 488  C CE  . LYS A 1 59  ? 40.600 -4.011  6.385   1.00 86.07  ? 53  LYS A CE  1 
ATOM 489  N NZ  . LYS A 1 59  ? 39.949 -5.117  7.146   1.00 75.37  ? 53  LYS A NZ  1 
ATOM 490  N N   . ILE A 1 60  ? 39.135 -1.967  0.065   1.00 59.04  ? 54  ILE A N   1 
ATOM 491  C CA  . ILE A 1 60  ? 38.868 -2.428  -1.292  1.00 49.87  ? 54  ILE A CA  1 
ATOM 492  C C   . ILE A 1 60  ? 38.851 -1.285  -2.302  1.00 37.98  ? 54  ILE A C   1 
ATOM 493  O O   . ILE A 1 60  ? 39.110 -1.518  -3.490  1.00 36.91  ? 54  ILE A O   1 
ATOM 494  C CB  . ILE A 1 60  ? 37.544 -3.213  -1.311  1.00 32.37  ? 54  ILE A CB  1 
ATOM 495  C CG1 . ILE A 1 60  ? 37.615 -4.390  -0.333  1.00 32.28  ? 54  ILE A CG1 1 
ATOM 496  C CG2 . ILE A 1 60  ? 37.242 -3.751  -2.699  1.00 34.43  ? 54  ILE A CG2 1 
ATOM 497  C CD1 . ILE A 1 60  ? 38.690 -5.400  -0.671  1.00 47.44  ? 54  ILE A CD1 1 
ATOM 498  N N   . ASN A 1 61  ? 38.594 -0.051  -1.861  1.00 38.07  ? 55  ASN A N   1 
ATOM 499  C CA  . ASN A 1 61  ? 38.400 1.087   -2.763  1.00 35.84  ? 55  ASN A CA  1 
ATOM 500  C C   . ASN A 1 61  ? 37.297 0.769   -3.767  1.00 30.03  ? 55  ASN A C   1 
ATOM 501  O O   . ASN A 1 61  ? 37.490 0.815   -4.984  1.00 42.75  ? 55  ASN A O   1 
ATOM 502  C CB  . ASN A 1 61  ? 39.700 1.466   -3.477  1.00 49.84  ? 55  ASN A CB  1 
ATOM 503  C CG  . ASN A 1 61  ? 40.838 1.748   -2.516  1.00 83.74  ? 55  ASN A CG  1 
ATOM 504  O OD1 . ASN A 1 61  ? 40.890 2.805   -1.888  1.00 104.91 ? 55  ASN A OD1 1 
ATOM 505  N ND2 . ASN A 1 61  ? 41.758 0.796   -2.396  1.00 77.57  ? 55  ASN A ND2 1 
ATOM 506  N N   . THR A 1 62  ? 36.119 0.442   -3.229  1.00 23.29  ? 56  THR A N   1 
ATOM 507  C CA  . THR A 1 62  ? 35.091 -0.236  -4.014  1.00 34.32  ? 56  THR A CA  1 
ATOM 508  C C   . THR A 1 62  ? 34.617 0.596   -5.200  1.00 41.13  ? 56  THR A C   1 
ATOM 509  O O   . THR A 1 62  ? 34.135 0.039   -6.190  1.00 39.47  ? 56  THR A O   1 
ATOM 510  C CB  . THR A 1 62  ? 33.908 -0.597  -3.117  1.00 27.67  ? 56  THR A CB  1 
ATOM 511  O OG1 . THR A 1 62  ? 33.485 0.566   -2.400  1.00 44.15  ? 56  THR A OG1 1 
ATOM 512  C CG2 . THR A 1 62  ? 34.307 -1.668  -2.126  1.00 28.95  ? 56  THR A CG2 1 
ATOM 513  N N   . TYR A 1 63  ? 34.749 1.920   -5.128  1.00 42.40  ? 57  TYR A N   1 
ATOM 514  C CA  . TYR A 1 63  ? 34.298 2.771   -6.227  1.00 35.32  ? 57  TYR A CA  1 
ATOM 515  C C   . TYR A 1 63  ? 35.186 2.612   -7.455  1.00 39.29  ? 57  TYR A C   1 
ATOM 516  O O   . TYR A 1 63  ? 34.695 2.376   -8.568  1.00 51.86  ? 57  TYR A O   1 
ATOM 517  C CB  . TYR A 1 63  ? 34.263 4.228   -5.768  1.00 39.46  ? 57  TYR A CB  1 
ATOM 518  C CG  . TYR A 1 63  ? 33.547 5.170   -6.711  1.00 39.65  ? 57  TYR A CG  1 
ATOM 519  C CD1 . TYR A 1 63  ? 32.202 4.998   -7.013  1.00 50.58  ? 57  TYR A CD1 1 
ATOM 520  C CD2 . TYR A 1 63  ? 34.210 6.254   -7.272  1.00 33.31  ? 57  TYR A CD2 1 
ATOM 521  C CE1 . TYR A 1 63  ? 31.545 5.874   -7.863  1.00 47.16  ? 57  TYR A CE1 1 
ATOM 522  C CE2 . TYR A 1 63  ? 33.563 7.134   -8.121  1.00 39.44  ? 57  TYR A CE2 1 
ATOM 523  C CZ  . TYR A 1 63  ? 32.232 6.941   -8.411  1.00 47.71  ? 57  TYR A CZ  1 
ATOM 524  O OH  . TYR A 1 63  ? 31.591 7.815   -9.259  1.00 60.91  ? 57  TYR A OH  1 
ATOM 525  N N   . GLN A 1 64  ? 36.497 2.758   -7.281  1.00 40.69  ? 58  GLN A N   1 
ATOM 526  C CA  . GLN A 1 64  ? 37.382 2.611   -8.428  1.00 43.47  ? 58  GLN A CA  1 
ATOM 527  C C   . GLN A 1 64  ? 37.419 1.158   -8.890  1.00 42.79  ? 58  GLN A C   1 
ATOM 528  O O   . GLN A 1 64  ? 37.530 0.886   -10.093 1.00 55.51  ? 58  GLN A O   1 
ATOM 529  C CB  . GLN A 1 64  ? 38.775 3.125   -8.066  1.00 42.09  ? 58  GLN A CB  1 
ATOM 530  C CG  . GLN A 1 64  ? 39.765 3.141   -9.203  1.00 52.60  ? 58  GLN A CG  1 
ATOM 531  C CD  . GLN A 1 64  ? 39.211 3.806   -10.445 1.00 87.03  ? 58  GLN A CD  1 
ATOM 532  O OE1 . GLN A 1 64  ? 38.776 4.958   -10.402 1.00 101.40 ? 58  GLN A OE1 1 
ATOM 533  N NE2 . GLN A 1 64  ? 39.231 3.090   -11.562 1.00 81.98  ? 58  GLN A NE2 1 
ATOM 534  N N   . PHE A 1 65  ? 37.284 0.218   -7.947  1.00 28.57  ? 59  PHE A N   1 
ATOM 535  C CA  . PHE A 1 65  ? 37.100 -1.188  -8.294  1.00 35.92  ? 59  PHE A CA  1 
ATOM 536  C C   . PHE A 1 65  ? 35.884 -1.375  -9.197  1.00 38.07  ? 59  PHE A C   1 
ATOM 537  O O   . PHE A 1 65  ? 35.944 -2.118  -10.182 1.00 34.54  ? 59  PHE A O   1 
ATOM 538  C CB  . PHE A 1 65  ? 36.965 -2.019  -7.012  1.00 38.61  ? 59  PHE A CB  1 
ATOM 539  C CG  . PHE A 1 65  ? 37.116 -3.504  -7.220  1.00 37.02  ? 59  PHE A CG  1 
ATOM 540  C CD1 . PHE A 1 65  ? 36.115 -4.244  -7.827  1.00 32.45  ? 59  PHE A CD1 1 
ATOM 541  C CD2 . PHE A 1 65  ? 38.264 -4.160  -6.808  1.00 54.05  ? 59  PHE A CD2 1 
ATOM 542  C CE1 . PHE A 1 65  ? 36.256 -5.606  -8.018  1.00 33.48  ? 59  PHE A CE1 1 
ATOM 543  C CE2 . PHE A 1 65  ? 38.408 -5.523  -6.997  1.00 47.31  ? 59  PHE A CE2 1 
ATOM 544  C CZ  . PHE A 1 65  ? 37.403 -6.244  -7.601  1.00 37.08  ? 59  PHE A CZ  1 
ATOM 545  N N   . MET A 1 66  ? 34.773 -0.711  -8.871  1.00 41.35  ? 60  MET A N   1 
ATOM 546  C CA  . MET A 1 66  ? 33.586 -0.749  -9.721  1.00 32.87  ? 60  MET A CA  1 
ATOM 547  C C   . MET A 1 66  ? 33.876 -0.171  -11.097 1.00 28.06  ? 60  MET A C   1 
ATOM 548  O O   . MET A 1 66  ? 33.410 -0.701  -12.111 1.00 29.54  ? 60  MET A O   1 
ATOM 549  C CB  . MET A 1 66  ? 32.442 0.025   -9.064  1.00 28.29  ? 60  MET A CB  1 
ATOM 550  C CG  . MET A 1 66  ? 31.647 -0.745  -8.036  1.00 27.43  ? 60  MET A CG  1 
ATOM 551  S SD  . MET A 1 66  ? 30.700 -2.095  -8.761  1.00 53.28  ? 60  MET A SD  1 
ATOM 552  C CE  . MET A 1 66  ? 29.487 -1.174  -9.707  1.00 25.35  ? 60  MET A CE  1 
ATOM 553  N N   . TRP A 1 67  ? 34.619 0.934   -11.151 1.00 29.03  ? 61  TRP A N   1 
ATOM 554  C CA  . TRP A 1 67  ? 34.979 1.486   -12.454 1.00 26.32  ? 61  TRP A CA  1 
ATOM 555  C C   . TRP A 1 67  ? 35.961 0.608   -13.217 1.00 32.22  ? 61  TRP A C   1 
ATOM 556  O O   . TRP A 1 67  ? 36.170 0.839   -14.413 1.00 37.10  ? 61  TRP A O   1 
ATOM 557  C CB  . TRP A 1 67  ? 35.531 2.905   -12.311 1.00 24.99  ? 61  TRP A CB  1 
ATOM 558  C CG  . TRP A 1 67  ? 34.465 3.872   -11.910 1.00 28.99  ? 61  TRP A CG  1 
ATOM 559  C CD1 . TRP A 1 67  ? 34.438 4.655   -10.796 1.00 46.74  ? 61  TRP A CD1 1 
ATOM 560  C CD2 . TRP A 1 67  ? 33.233 4.115   -12.602 1.00 40.27  ? 61  TRP A CD2 1 
ATOM 561  N NE1 . TRP A 1 67  ? 33.276 5.392   -10.766 1.00 65.54  ? 61  TRP A NE1 1 
ATOM 562  C CE2 . TRP A 1 67  ? 32.518 5.075   -11.862 1.00 54.21  ? 61  TRP A CE2 1 
ATOM 563  C CE3 . TRP A 1 67  ? 32.672 3.620   -13.784 1.00 44.01  ? 61  TRP A CE3 1 
ATOM 564  C CZ2 . TRP A 1 67  ? 31.271 5.550   -12.262 1.00 53.68  ? 61  TRP A CZ2 1 
ATOM 565  C CZ3 . TRP A 1 67  ? 31.435 4.091   -14.180 1.00 38.11  ? 61  TRP A CZ3 1 
ATOM 566  C CH2 . TRP A 1 67  ? 30.748 5.046   -13.423 1.00 48.67  ? 61  TRP A CH2 1 
ATOM 567  N N   . CYS A 1 68  ? 36.564 -0.382  -12.566 1.00 31.48  ? 62  CYS A N   1 
ATOM 568  C CA  . CYS A 1 68  ? 37.227 -1.450  -13.304 1.00 28.43  ? 62  CYS A CA  1 
ATOM 569  C C   . CYS A 1 68  ? 36.259 -2.546  -13.736 1.00 30.00  ? 62  CYS A C   1 
ATOM 570  O O   . CYS A 1 68  ? 36.654 -3.440  -14.494 1.00 17.02  ? 62  CYS A O   1 
ATOM 571  C CB  . CYS A 1 68  ? 38.343 -2.067  -12.459 1.00 40.74  ? 62  CYS A CB  1 
ATOM 572  S SG  . CYS A 1 68  ? 39.639 -0.920  -11.933 1.00 43.06  ? 62  CYS A SG  1 
ATOM 573  N N   . ILE A 1 69  ? 35.006 -2.494  -13.281 1.00 49.69  ? 63  ILE A N   1 
ATOM 574  C CA  . ILE A 1 69  ? 34.051 -3.571  -13.456 1.00 39.25  ? 63  ILE A CA  1 
ATOM 575  C C   . ILE A 1 69  ? 32.813 -3.149  -14.246 1.00 38.52  ? 63  ILE A C   1 
ATOM 576  O O   . ILE A 1 69  ? 32.054 -4.010  -14.713 1.00 44.03  ? 63  ILE A O   1 
ATOM 577  C CB  . ILE A 1 69  ? 33.654 -4.176  -12.084 1.00 27.39  ? 63  ILE A CB  1 
ATOM 578  C CG1 . ILE A 1 69  ? 34.865 -4.882  -11.476 1.00 34.61  ? 63  ILE A CG1 1 
ATOM 579  C CG2 . ILE A 1 69  ? 32.556 -5.215  -12.173 1.00 42.43  ? 63  ILE A CG2 1 
ATOM 580  C CD1 . ILE A 1 69  ? 35.344 -6.074  -12.288 1.00 49.48  ? 63  ILE A CD1 1 
ATOM 581  N N   . VAL A 1 70  ? 32.598 -1.849  -14.451 1.00 33.38  ? 64  VAL A N   1 
ATOM 582  C CA  . VAL A 1 70  ? 31.639 -1.368  -15.436 1.00 31.83  ? 64  VAL A CA  1 
ATOM 583  C C   . VAL A 1 70  ? 32.339 -0.341  -16.312 1.00 36.10  ? 64  VAL A C   1 
ATOM 584  O O   . VAL A 1 70  ? 33.260 0.357   -15.874 1.00 34.98  ? 64  VAL A O   1 
ATOM 585  C CB  . VAL A 1 70  ? 30.362 -0.761  -14.804 1.00 25.93  ? 64  VAL A CB  1 
ATOM 586  C CG1 . VAL A 1 70  ? 29.769 -1.701  -13.769 1.00 39.94  ? 64  VAL A CG1 1 
ATOM 587  C CG2 . VAL A 1 70  ? 30.644 0.602   -14.203 1.00 30.80  ? 64  VAL A CG2 1 
ATOM 588  N N   . ASP A 1 71  ? 31.911 -0.269  -17.569 1.00 44.79  ? 65  ASP A N   1 
ATOM 589  C CA  . ASP A 1 71  ? 32.421 0.716   -18.510 1.00 51.16  ? 65  ASP A CA  1 
ATOM 590  C C   . ASP A 1 71  ? 31.358 1.693   -18.991 1.00 45.33  ? 65  ASP A C   1 
ATOM 591  O O   . ASP A 1 71  ? 31.670 2.570   -19.808 1.00 27.60  ? 65  ASP A O   1 
ATOM 592  C CB  . ASP A 1 71  ? 33.055 0.021   -19.725 1.00 58.02  ? 65  ASP A CB  1 
ATOM 593  C CG  . ASP A 1 71  ? 32.033 -0.707  -20.590 1.00 53.64  ? 65  ASP A CG  1 
ATOM 594  O OD1 . ASP A 1 71  ? 30.872 -0.866  -20.158 1.00 40.28  ? 65  ASP A OD1 1 
ATOM 595  O OD2 . ASP A 1 71  ? 32.390 -1.111  -21.716 1.00 62.48  ? 65  ASP A OD2 1 
ATOM 596  N N   . THR A 1 72  ? 30.120 1.566   -18.518 1.00 45.29  ? 66  THR A N   1 
ATOM 597  C CA  . THR A 1 72  ? 28.999 2.357   -19.007 1.00 45.01  ? 66  THR A CA  1 
ATOM 598  C C   . THR A 1 72  ? 28.518 3.287   -17.903 1.00 40.94  ? 66  THR A C   1 
ATOM 599  O O   . THR A 1 72  ? 28.043 2.825   -16.861 1.00 55.47  ? 66  THR A O   1 
ATOM 600  C CB  . THR A 1 72  ? 27.858 1.455   -19.483 1.00 35.41  ? 66  THR A CB  1 
ATOM 601  O OG1 . THR A 1 72  ? 28.285 0.702   -20.625 1.00 57.44  ? 66  THR A OG1 1 
ATOM 602  C CG2 . THR A 1 72  ? 26.624 2.281   -19.830 1.00 52.30  ? 66  THR A CG2 1 
ATOM 603  N N   . ILE A 1 73  ? 28.627 4.587   -18.142 1.00 39.82  ? 67  ILE A N   1 
ATOM 604  C CA  . ILE A 1 73  ? 28.160 5.579   -17.167 1.00 40.82  ? 67  ILE A CA  1 
ATOM 605  C C   . ILE A 1 73  ? 26.637 5.500   -17.073 1.00 48.62  ? 67  ILE A C   1 
ATOM 606  O O   . ILE A 1 73  ? 25.970 5.296   -18.102 1.00 44.47  ? 67  ILE A O   1 
ATOM 607  C CB  . ILE A 1 73  ? 28.617 6.983   -17.576 1.00 42.25  ? 67  ILE A CB  1 
ATOM 608  C CG1 . ILE A 1 73  ? 30.121 6.989   -17.851 1.00 43.14  ? 67  ILE A CG1 1 
ATOM 609  C CG2 . ILE A 1 73  ? 28.275 8.002   -16.500 1.00 38.43  ? 67  ILE A CG2 1 
ATOM 610  C CD1 . ILE A 1 73  ? 30.666 8.356   -18.181 1.00 52.65  ? 67  ILE A CD1 1 
ATOM 611  N N   . PRO A 1 74  ? 26.060 5.617   -15.876 1.00 43.08  ? 68  PRO A N   1 
ATOM 612  C CA  . PRO A 1 74  ? 24.596 5.599   -15.759 1.00 32.10  ? 68  PRO A CA  1 
ATOM 613  C C   . PRO A 1 74  ? 23.943 6.640   -16.656 1.00 35.90  ? 68  PRO A C   1 
ATOM 614  O O   . PRO A 1 74  ? 24.393 7.784   -16.747 1.00 53.16  ? 68  PRO A O   1 
ATOM 615  C CB  . PRO A 1 74  ? 24.370 5.910   -14.278 1.00 29.24  ? 68  PRO A CB  1 
ATOM 616  C CG  . PRO A 1 74  ? 25.557 5.306   -13.609 1.00 28.52  ? 68  PRO A CG  1 
ATOM 617  C CD  . PRO A 1 74  ? 26.715 5.497   -14.562 1.00 22.57  ? 68  PRO A CD  1 
ATOM 618  N N   . ALA A 1 75  ? 22.874 6.227   -17.334 1.00 38.75  ? 69  ALA A N   1 
ATOM 619  C CA  . ALA A 1 75  ? 22.145 7.096   -18.243 1.00 45.31  ? 69  ALA A CA  1 
ATOM 620  C C   . ALA A 1 75  ? 20.761 7.458   -17.726 1.00 40.99  ? 69  ALA A C   1 
ATOM 621  O O   . ALA A 1 75  ? 20.056 8.237   -18.376 1.00 60.03  ? 69  ALA A O   1 
ATOM 622  C CB  . ALA A 1 75  ? 22.029 6.440   -19.622 1.00 49.45  ? 69  ALA A CB  1 
ATOM 623  N N   . SER A 1 76  ? 20.350 6.907   -16.588 1.00 45.98  ? 70  SER A N   1 
ATOM 624  C CA  . SER A 1 76  ? 19.065 7.238   -15.990 1.00 50.25  ? 70  SER A CA  1 
ATOM 625  C C   . SER A 1 76  ? 19.140 6.938   -14.500 1.00 58.58  ? 70  SER A C   1 
ATOM 626  O O   . SER A 1 76  ? 20.133 6.402   -14.002 1.00 61.92  ? 70  SER A O   1 
ATOM 627  C CB  . SER A 1 76  ? 17.918 6.471   -16.656 1.00 47.69  ? 70  SER A CB  1 
ATOM 628  O OG  . SER A 1 76  ? 18.119 5.071   -16.582 1.00 56.76  ? 70  SER A OG  1 
ATOM 629  N N   . GLN A 1 77  ? 18.067 7.295   -13.791 1.00 54.76  ? 71  GLN A N   1 
ATOM 630  C CA  . GLN A 1 77  ? 18.043 7.105   -12.345 1.00 66.09  ? 71  GLN A CA  1 
ATOM 631  C C   . GLN A 1 77  ? 18.092 5.629   -11.977 1.00 58.02  ? 71  GLN A C   1 
ATOM 632  O O   . GLN A 1 77  ? 18.698 5.254   -10.964 1.00 64.18  ? 71  GLN A O   1 
ATOM 633  C CB  . GLN A 1 77  ? 16.792 7.754   -11.750 1.00 69.76  ? 71  GLN A CB  1 
ATOM 634  C CG  . GLN A 1 77  ? 16.652 9.255   -12.016 1.00 85.25  ? 71  GLN A CG  1 
ATOM 635  C CD  . GLN A 1 77  ? 17.891 10.049  -11.650 1.00 121.77 ? 71  GLN A CD  1 
ATOM 636  O OE1 . GLN A 1 77  ? 18.044 10.500  -10.513 1.00 123.40 ? 71  GLN A OE1 1 
ATOM 637  N NE2 . GLN A 1 77  ? 18.773 10.250  -12.627 1.00 113.86 ? 71  GLN A NE2 1 
ATOM 638  N N   . TYR A 1 78  ? 17.455 4.779   -12.784 1.00 41.13  ? 72  TYR A N   1 
ATOM 639  C CA  . TYR A 1 78  ? 17.485 3.345   -12.524 1.00 47.93  ? 72  TYR A CA  1 
ATOM 640  C C   . TYR A 1 78  ? 18.906 2.801   -12.615 1.00 49.60  ? 72  TYR A C   1 
ATOM 641  O O   . TYR A 1 78  ? 19.300 1.945   -11.815 1.00 48.23  ? 72  TYR A O   1 
ATOM 642  C CB  . TYR A 1 78  ? 16.563 2.623   -13.506 1.00 39.46  ? 72  TYR A CB  1 
ATOM 643  C CG  . TYR A 1 78  ? 15.140 3.140   -13.507 1.00 47.62  ? 72  TYR A CG  1 
ATOM 644  C CD1 . TYR A 1 78  ? 14.279 2.878   -12.448 1.00 47.05  ? 72  TYR A CD1 1 
ATOM 645  C CD2 . TYR A 1 78  ? 14.661 3.894   -14.570 1.00 57.72  ? 72  TYR A CD2 1 
ATOM 646  C CE1 . TYR A 1 78  ? 12.975 3.355   -12.453 1.00 58.76  ? 72  TYR A CE1 1 
ATOM 647  C CE2 . TYR A 1 78  ? 13.364 4.373   -14.584 1.00 45.64  ? 72  TYR A CE2 1 
ATOM 648  C CZ  . TYR A 1 78  ? 12.525 4.102   -13.525 1.00 47.64  ? 72  TYR A CZ  1 
ATOM 649  O OH  . TYR A 1 78  ? 11.235 4.581   -13.544 1.00 65.79  ? 72  TYR A OH  1 
ATOM 650  N N   . ALA A 1 79  ? 19.692 3.289   -13.577 1.00 36.58  ? 73  ALA A N   1 
ATOM 651  C CA  . ALA A 1 79  ? 21.088 2.873   -13.669 1.00 33.01  ? 73  ALA A CA  1 
ATOM 652  C C   . ALA A 1 79  ? 21.879 3.334   -12.451 1.00 38.66  ? 73  ALA A C   1 
ATOM 653  O O   . ALA A 1 79  ? 22.765 2.618   -11.967 1.00 34.53  ? 73  ALA A O   1 
ATOM 654  C CB  . ALA A 1 79  ? 21.716 3.410   -14.955 1.00 37.58  ? 73  ALA A CB  1 
ATOM 655  N N   . GLU A 1 80  ? 21.575 4.528   -11.940 1.00 35.95  ? 74  GLU A N   1 
ATOM 656  C CA  . GLU A 1 80  ? 22.218 4.986   -10.713 1.00 32.25  ? 74  GLU A CA  1 
ATOM 657  C C   . GLU A 1 80  ? 21.901 4.056   -9.551  1.00 44.62  ? 74  GLU A C   1 
ATOM 658  O O   . GLU A 1 80  ? 22.789 3.689   -8.774  1.00 41.36  ? 74  GLU A O   1 
ATOM 659  C CB  . GLU A 1 80  ? 21.784 6.413   -10.383 1.00 41.03  ? 74  GLU A CB  1 
ATOM 660  C CG  . GLU A 1 80  ? 22.264 7.445   -11.371 1.00 46.70  ? 74  GLU A CG  1 
ATOM 661  C CD  . GLU A 1 80  ? 21.765 8.826   -11.028 1.00 59.83  ? 74  GLU A CD  1 
ATOM 662  O OE1 . GLU A 1 80  ? 20.974 8.951   -10.068 1.00 61.68  ? 74  GLU A OE1 1 
ATOM 663  O OE2 . GLU A 1 80  ? 22.159 9.786   -11.720 1.00 69.74  ? 74  GLU A OE2 1 
ATOM 664  N N   . GLU A 1 81  ? 20.632 3.662   -9.418  1.00 41.42  ? 75  GLU A N   1 
ATOM 665  C CA  . GLU A 1 81  ? 20.258 2.749   -8.342  1.00 50.93  ? 75  GLU A CA  1 
ATOM 666  C C   . GLU A 1 81  ? 20.939 1.393   -8.505  1.00 52.21  ? 75  GLU A C   1 
ATOM 667  O O   . GLU A 1 81  ? 21.359 0.776   -7.515  1.00 63.13  ? 75  GLU A O   1 
ATOM 668  C CB  . GLU A 1 81  ? 18.737 2.589   -8.290  1.00 47.50  ? 75  GLU A CB  1 
ATOM 669  C CG  . GLU A 1 81  ? 18.004 3.836   -7.819  1.00 60.45  ? 75  GLU A CG  1 
ATOM 670  C CD  . GLU A 1 81  ? 16.501 3.724   -7.986  1.00 95.61  ? 75  GLU A CD  1 
ATOM 671  O OE1 . GLU A 1 81  ? 16.034 2.689   -8.508  1.00 81.77  ? 75  GLU A OE1 1 
ATOM 672  O OE2 . GLU A 1 81  ? 15.788 4.674   -7.601  1.00 115.44 ? 75  GLU A OE2 1 
ATOM 673  N N   . ILE A 1 82  ? 21.068 0.926   -9.749  1.00 37.43  ? 76  ILE A N   1 
ATOM 674  C CA  . ILE A 1 82  ? 21.729 -0.354  -10.006 1.00 33.06  ? 76  ILE A CA  1 
ATOM 675  C C   . ILE A 1 82  ? 23.193 -0.289  -9.594  1.00 33.52  ? 76  ILE A C   1 
ATOM 676  O O   . ILE A 1 82  ? 23.709 -1.191  -8.920  1.00 38.31  ? 76  ILE A O   1 
ATOM 677  C CB  . ILE A 1 82  ? 21.578 -0.746  -11.487 1.00 48.48  ? 76  ILE A CB  1 
ATOM 678  C CG1 . ILE A 1 82  ? 20.183 -1.316  -11.745 1.00 48.41  ? 76  ILE A CG1 1 
ATOM 679  C CG2 . ILE A 1 82  ? 22.654 -1.748  -11.887 1.00 49.19  ? 76  ILE A CG2 1 
ATOM 680  C CD1 . ILE A 1 82  ? 19.784 -1.312  -13.198 1.00 54.91  ? 76  ILE A CD1 1 
ATOM 681  N N   . PHE A 1 83  ? 23.888 0.773   -10.003 1.00 27.01  ? 77  PHE A N   1 
ATOM 682  C CA  . PHE A 1 83  ? 25.288 0.933   -9.625  1.00 38.67  ? 77  PHE A CA  1 
ATOM 683  C C   . PHE A 1 83  ? 25.438 1.028   -8.110  1.00 55.13  ? 77  PHE A C   1 
ATOM 684  O O   . PHE A 1 83  ? 26.360 0.442   -7.531  1.00 50.45  ? 77  PHE A O   1 
ATOM 685  C CB  . PHE A 1 83  ? 25.874 2.167   -10.320 1.00 32.78  ? 77  PHE A CB  1 
ATOM 686  C CG  . PHE A 1 83  ? 27.351 2.366   -10.093 1.00 23.15  ? 77  PHE A CG  1 
ATOM 687  C CD1 . PHE A 1 83  ? 27.827 2.892   -8.902  1.00 44.37  ? 77  PHE A CD1 1 
ATOM 688  C CD2 . PHE A 1 83  ? 28.262 2.033   -11.079 1.00 17.74  ? 77  PHE A CD2 1 
ATOM 689  C CE1 . PHE A 1 83  ? 29.181 3.077   -8.704  1.00 47.31  ? 77  PHE A CE1 1 
ATOM 690  C CE2 . PHE A 1 83  ? 29.618 2.218   -10.883 1.00 28.23  ? 77  PHE A CE2 1 
ATOM 691  C CZ  . PHE A 1 83  ? 30.075 2.739   -9.694  1.00 34.82  ? 77  PHE A CZ  1 
ATOM 692  N N   . LYS A 1 84  ? 24.541 1.766   -7.452  1.00 43.16  ? 78  LYS A N   1 
ATOM 693  C CA  . LYS A 1 84  ? 24.602 1.897   -5.999  1.00 31.32  ? 78  LYS A CA  1 
ATOM 694  C C   . LYS A 1 84  ? 24.483 0.537   -5.319  1.00 35.57  ? 78  LYS A C   1 
ATOM 695  O O   . LYS A 1 84  ? 25.333 0.161   -4.497  1.00 55.11  ? 78  LYS A O   1 
ATOM 696  C CB  . LYS A 1 84  ? 23.499 2.847   -5.529  1.00 47.47  ? 78  LYS A CB  1 
ATOM 697  C CG  . LYS A 1 84  ? 23.274 2.889   -4.029  1.00 46.14  ? 78  LYS A CG  1 
ATOM 698  C CD  . LYS A 1 84  ? 22.292 3.996   -3.684  1.00 53.73  ? 78  LYS A CD  1 
ATOM 699  C CE  . LYS A 1 84  ? 20.938 3.746   -4.321  1.00 60.29  ? 78  LYS A CE  1 
ATOM 700  N NZ  . LYS A 1 84  ? 19.945 4.782   -3.928  1.00 73.59  ? 78  LYS A NZ  1 
ATOM 701  N N   . SER A 1 85  ? 23.433 -0.220  -5.657  1.00 31.42  ? 79  SER A N   1 
ATOM 702  C CA  . SER A 1 85  ? 23.236 -1.531  -5.046  1.00 37.39  ? 79  SER A CA  1 
ATOM 703  C C   . SER A 1 85  ? 24.377 -2.484  -5.374  1.00 43.92  ? 79  SER A C   1 
ATOM 704  O O   . SER A 1 85  ? 24.759 -3.299  -4.527  1.00 52.14  ? 79  SER A O   1 
ATOM 705  C CB  . SER A 1 85  ? 21.904 -2.130  -5.495  1.00 36.04  ? 79  SER A CB  1 
ATOM 706  O OG  . SER A 1 85  ? 21.850 -2.231  -6.904  1.00 53.92  ? 79  SER A OG  1 
ATOM 707  N N   . SER A 1 86  ? 24.942 -2.395  -6.582  1.00 35.25  ? 80  SER A N   1 
ATOM 708  C CA  . SER A 1 86  ? 26.057 -3.269  -6.940  1.00 36.34  ? 80  SER A CA  1 
ATOM 709  C C   . SER A 1 86  ? 27.297 -2.950  -6.114  1.00 43.53  ? 80  SER A C   1 
ATOM 710  O O   . SER A 1 86  ? 28.001 -3.860  -5.659  1.00 35.82  ? 80  SER A O   1 
ATOM 711  C CB  . SER A 1 86  ? 26.364 -3.142  -8.432  1.00 33.58  ? 80  SER A CB  1 
ATOM 712  O OG  . SER A 1 86  ? 25.299 -3.643  -9.214  1.00 30.10  ? 80  SER A OG  1 
ATOM 713  N N   . LEU A 1 87  ? 27.588 -1.661  -5.929  1.00 48.73  ? 81  LEU A N   1 
ATOM 714  C CA  . LEU A 1 87  ? 28.700 -1.252  -5.078  1.00 35.88  ? 81  LEU A CA  1 
ATOM 715  C C   . LEU A 1 87  ? 28.526 -1.800  -3.668  1.00 40.53  ? 81  LEU A C   1 
ATOM 716  O O   . LEU A 1 87  ? 29.450 -2.402  -3.096  1.00 51.72  ? 81  LEU A O   1 
ATOM 717  C CB  . LEU A 1 87  ? 28.783 0.276   -5.067  1.00 37.99  ? 81  LEU A CB  1 
ATOM 718  C CG  . LEU A 1 87  ? 29.831 1.021   -4.247  1.00 39.20  ? 81  LEU A CG  1 
ATOM 719  C CD1 . LEU A 1 87  ? 31.187 0.866   -4.882  1.00 43.27  ? 81  LEU A CD1 1 
ATOM 720  C CD2 . LEU A 1 87  ? 29.456 2.488   -4.149  1.00 62.25  ? 81  LEU A CD2 1 
ATOM 721  N N   . HIS A 1 88  ? 27.332 -1.601  -3.097  1.00 33.48  ? 82  HIS A N   1 
ATOM 722  C CA  . HIS A 1 88  ? 27.044 -2.088  -1.750  1.00 25.44  ? 82  HIS A CA  1 
ATOM 723  C C   . HIS A 1 88  ? 27.247 -3.598  -1.661  1.00 36.12  ? 82  HIS A C   1 
ATOM 724  O O   . HIS A 1 88  ? 27.879 -4.106  -0.721  1.00 37.82  ? 82  HIS A O   1 
ATOM 725  C CB  . HIS A 1 88  ? 25.606 -1.725  -1.367  1.00 22.99  ? 82  HIS A CB  1 
ATOM 726  C CG  . HIS A 1 88  ? 25.354 -0.253  -1.273  1.00 25.42  ? 82  HIS A CG  1 
ATOM 727  N ND1 . HIS A 1 88  ? 24.145 0.267   -0.866  1.00 22.42  ? 82  HIS A ND1 1 
ATOM 728  C CD2 . HIS A 1 88  ? 26.143 0.808   -1.564  1.00 37.95  ? 82  HIS A CD2 1 
ATOM 729  C CE1 . HIS A 1 88  ? 24.206 1.587   -0.892  1.00 30.46  ? 82  HIS A CE1 1 
ATOM 730  N NE2 . HIS A 1 88  ? 25.406 1.940   -1.314  1.00 41.20  ? 82  HIS A NE2 1 
ATOM 731  N N   . PHE A 1 89  ? 26.689 -4.331  -2.630  1.00 43.22  ? 83  PHE A N   1 
ATOM 732  C CA  . PHE A 1 89  ? 26.790 -5.786  -2.645  1.00 40.16  ? 83  PHE A CA  1 
ATOM 733  C C   . PHE A 1 89  ? 28.237 -6.240  -2.720  1.00 32.78  ? 83  PHE A C   1 
ATOM 734  O O   . PHE A 1 89  ? 28.641 -7.154  -2.000  1.00 43.55  ? 83  PHE A O   1 
ATOM 735  C CB  . PHE A 1 89  ? 25.990 -6.355  -3.820  1.00 32.26  ? 83  PHE A CB  1 
ATOM 736  C CG  . PHE A 1 89  ? 26.076 -7.849  -3.945  1.00 22.00  ? 83  PHE A CG  1 
ATOM 737  C CD1 . PHE A 1 89  ? 25.433 -8.670  -3.036  1.00 29.20  ? 83  PHE A CD1 1 
ATOM 738  C CD2 . PHE A 1 89  ? 26.811 -8.434  -4.960  1.00 18.01  ? 83  PHE A CD2 1 
ATOM 739  C CE1 . PHE A 1 89  ? 25.515 -10.049 -3.140  1.00 22.16  ? 83  PHE A CE1 1 
ATOM 740  C CE2 . PHE A 1 89  ? 26.895 -9.813  -5.068  1.00 19.89  ? 83  PHE A CE2 1 
ATOM 741  C CZ  . PHE A 1 89  ? 26.247 -10.619 -4.159  1.00 18.03  ? 83  PHE A CZ  1 
ATOM 742  N N   . LEU A 1 90  ? 29.027 -5.630  -3.606  1.00 25.71  ? 84  LEU A N   1 
ATOM 743  C CA  . LEU A 1 90  ? 30.449 -5.950  -3.694  1.00 38.23  ? 84  LEU A CA  1 
ATOM 744  C C   . LEU A 1 90  ? 31.126 -5.791  -2.335  1.00 49.21  ? 84  LEU A C   1 
ATOM 745  O O   . LEU A 1 90  ? 31.769 -6.724  -1.818  1.00 56.53  ? 84  LEU A O   1 
ATOM 746  C CB  . LEU A 1 90  ? 31.099 -5.038  -4.739  1.00 44.31  ? 84  LEU A CB  1 
ATOM 747  C CG  . LEU A 1 90  ? 32.591 -5.072  -5.060  1.00 35.52  ? 84  LEU A CG  1 
ATOM 748  C CD1 . LEU A 1 90  ? 32.932 -6.347  -5.779  1.00 24.84  ? 84  LEU A CD1 1 
ATOM 749  C CD2 . LEU A 1 90  ? 32.979 -3.860  -5.904  1.00 32.45  ? 84  LEU A CD2 1 
ATOM 750  N N   . CYS A 1 91  ? 30.967 -4.604  -1.737  1.00 51.88  ? 85  CYS A N   1 
ATOM 751  C CA  . CYS A 1 91  ? 31.662 -4.279  -0.494  1.00 43.67  ? 85  CYS A CA  1 
ATOM 752  C C   . CYS A 1 91  ? 31.312 -5.259  0.619   1.00 37.42  ? 85  CYS A C   1 
ATOM 753  O O   . CYS A 1 91  ? 32.194 -5.713  1.354   1.00 36.45  ? 85  CYS A O   1 
ATOM 754  C CB  . CYS A 1 91  ? 31.337 -2.846  -0.069  1.00 26.70  ? 85  CYS A CB  1 
ATOM 755  S SG  . CYS A 1 91  ? 32.308 -2.264  1.339   1.00 37.53  ? 85  CYS A SG  1 
ATOM 756  N N   . ALA A 1 92  ? 30.030 -5.600  0.764   1.00 38.53  ? 86  ALA A N   1 
ATOM 757  C CA  . ALA A 1 92  ? 29.674 -6.496  1.863   1.00 35.56  ? 86  ALA A CA  1 
ATOM 758  C C   . ALA A 1 92  ? 29.901 -7.966  1.519   1.00 41.10  ? 86  ALA A C   1 
ATOM 759  O O   . ALA A 1 92  ? 30.105 -8.788  2.425   1.00 57.53  ? 86  ALA A O   1 
ATOM 760  C CB  . ALA A 1 92  ? 28.226 -6.265  2.287   1.00 56.24  ? 86  ALA A CB  1 
ATOM 761  N N   . LEU A 1 93  ? 29.893 -8.318  0.230   1.00 40.18  ? 87  LEU A N   1 
ATOM 762  C CA  . LEU A 1 93  ? 30.212 -9.683  -0.166  1.00 42.87  ? 87  LEU A CA  1 
ATOM 763  C C   . LEU A 1 93  ? 31.643 -10.031 0.204   1.00 49.48  ? 87  LEU A C   1 
ATOM 764  O O   . LEU A 1 93  ? 31.923 -11.155 0.638   1.00 46.67  ? 87  LEU A O   1 
ATOM 765  C CB  . LEU A 1 93  ? 29.985 -9.867  -1.669  1.00 33.78  ? 87  LEU A CB  1 
ATOM 766  C CG  . LEU A 1 93  ? 30.293 -11.230 -2.299  1.00 43.54  ? 87  LEU A CG  1 
ATOM 767  C CD1 . LEU A 1 93  ? 29.495 -12.331 -1.630  1.00 48.82  ? 87  LEU A CD1 1 
ATOM 768  C CD2 . LEU A 1 93  ? 30.028 -11.215 -3.802  1.00 40.66  ? 87  LEU A CD2 1 
ATOM 769  N N   . PHE A 1 94  ? 32.567 -9.077  0.049   1.00 60.30  ? 88  PHE A N   1 
ATOM 770  C CA  . PHE A 1 94  ? 33.933 -9.360  0.492   1.00 57.17  ? 88  PHE A CA  1 
ATOM 771  C C   . PHE A 1 94  ? 34.017 -9.583  2.002   1.00 56.97  ? 88  PHE A C   1 
ATOM 772  O O   . PHE A 1 94  ? 34.783 -10.444 2.457   1.00 55.40  ? 88  PHE A O   1 
ATOM 773  C CB  . PHE A 1 94  ? 34.891 -8.256  0.040   1.00 40.64  ? 88  PHE A CB  1 
ATOM 774  C CG  . PHE A 1 94  ? 35.079 -8.205  -1.448  1.00 48.30  ? 88  PHE A CG  1 
ATOM 775  C CD1 . PHE A 1 94  ? 35.138 -9.383  -2.176  1.00 53.14  ? 88  PHE A CD1 1 
ATOM 776  C CD2 . PHE A 1 94  ? 35.226 -7.002  -2.115  1.00 51.44  ? 88  PHE A CD2 1 
ATOM 777  C CE1 . PHE A 1 94  ? 35.316 -9.364  -3.545  1.00 76.83  ? 88  PHE A CE1 1 
ATOM 778  C CE2 . PHE A 1 94  ? 35.411 -6.976  -3.486  1.00 55.51  ? 88  PHE A CE2 1 
ATOM 779  C CZ  . PHE A 1 94  ? 35.455 -8.161  -4.201  1.00 68.84  ? 88  PHE A CZ  1 
ATOM 780  N N   . LEU A 1 95  ? 33.231 -8.844  2.791   1.00 62.87  ? 89  LEU A N   1 
ATOM 781  C CA  . LEU A 1 95  ? 33.218 -9.065  4.235   1.00 58.24  ? 89  LEU A CA  1 
ATOM 782  C C   . LEU A 1 95  ? 32.655 -10.434 4.593   1.00 54.27  ? 89  LEU A C   1 
ATOM 783  O O   . LEU A 1 95  ? 33.116 -11.065 5.551   1.00 54.46  ? 89  LEU A O   1 
ATOM 784  C CB  . LEU A 1 95  ? 32.408 -7.972  4.929   1.00 50.69  ? 89  LEU A CB  1 
ATOM 785  C CG  . LEU A 1 95  ? 32.508 -7.970  6.454   1.00 61.72  ? 89  LEU A CG  1 
ATOM 786  C CD1 . LEU A 1 95  ? 33.963 -7.913  6.885   1.00 66.65  ? 89  LEU A CD1 1 
ATOM 787  C CD2 . LEU A 1 95  ? 31.724 -6.809  7.033   1.00 52.04  ? 89  LEU A CD2 1 
ATOM 788  N N   . VAL A 1 96  ? 31.648 -10.896 3.852   1.00 55.10  ? 90  VAL A N   1 
ATOM 789  C CA  . VAL A 1 96  ? 31.123 -12.241 4.083   1.00 53.47  ? 90  VAL A CA  1 
ATOM 790  C C   . VAL A 1 96  ? 32.166 -13.291 3.711   1.00 53.48  ? 90  VAL A C   1 
ATOM 791  O O   . VAL A 1 96  ? 32.287 -14.330 4.376   1.00 47.46  ? 90  VAL A O   1 
ATOM 792  C CB  . VAL A 1 96  ? 29.806 -12.443 3.310   1.00 46.10  ? 90  VAL A CB  1 
ATOM 793  C CG1 . VAL A 1 96  ? 29.366 -13.898 3.368   1.00 36.03  ? 90  VAL A CG1 1 
ATOM 794  C CG2 . VAL A 1 96  ? 28.721 -11.530 3.870   1.00 47.89  ? 90  VAL A CG2 1 
ATOM 795  N N   . ASP A 1 97  ? 32.923 -13.046 2.636   1.00 61.50  ? 91  ASP A N   1 
ATOM 796  C CA  . ASP A 1 97  ? 33.975 -13.976 2.236   1.00 65.58  ? 91  ASP A CA  1 
ATOM 797  C C   . ASP A 1 97  ? 35.099 -14.038 3.261   1.00 71.77  ? 91  ASP A C   1 
ATOM 798  O O   . ASP A 1 97  ? 35.700 -15.100 3.452   1.00 89.32  ? 91  ASP A O   1 
ATOM 799  C CB  . ASP A 1 97  ? 34.545 -13.591 0.867   1.00 73.49  ? 91  ASP A CB  1 
ATOM 800  C CG  . ASP A 1 97  ? 33.539 -13.749 -0.253  1.00 80.24  ? 91  ASP A CG  1 
ATOM 801  O OD1 . ASP A 1 97  ? 32.515 -14.426 -0.038  1.00 91.04  ? 91  ASP A OD1 1 
ATOM 802  O OD2 . ASP A 1 97  ? 33.774 -13.199 -1.349  1.00 64.92  ? 91  ASP A OD2 1 
ATOM 803  N N   . ASP A 1 98  ? 35.413 -12.913 3.910   1.00 75.58  ? 92  ASP A N   1 
ATOM 804  C CA  . ASP A 1 98  ? 36.455 -12.929 4.931   1.00 75.82  ? 92  ASP A CA  1 
ATOM 805  C C   . ASP A 1 98  ? 36.094 -13.844 6.094   1.00 63.64  ? 92  ASP A C   1 
ATOM 806  O O   . ASP A 1 98  ? 36.988 -14.388 6.750   1.00 78.99  ? 92  ASP A O   1 
ATOM 807  C CB  . ASP A 1 98  ? 36.730 -11.514 5.438   1.00 78.77  ? 92  ASP A CB  1 
ATOM 808  C CG  . ASP A 1 98  ? 37.426 -10.653 4.408   1.00 84.44  ? 92  ASP A CG  1 
ATOM 809  O OD1 . ASP A 1 98  ? 37.940 -11.207 3.415   1.00 90.99  ? 92  ASP A OD1 1 
ATOM 810  O OD2 . ASP A 1 98  ? 37.466 -9.419  4.597   1.00 84.75  ? 92  ASP A OD2 1 
ATOM 811  N N   . ALA A 1 99  ? 34.802 -14.034 6.360   1.00 46.29  ? 93  ALA A N   1 
ATOM 812  C CA  . ALA A 1 99  ? 34.379 -14.870 7.476   1.00 74.78  ? 93  ALA A CA  1 
ATOM 813  C C   . ALA A 1 99  ? 34.088 -16.309 7.063   1.00 78.73  ? 93  ALA A C   1 
ATOM 814  O O   . ALA A 1 99  ? 34.395 -17.237 7.818   1.00 73.71  ? 93  ALA A O   1 
ATOM 815  C CB  . ALA A 1 99  ? 33.146 -14.263 8.147   1.00 73.91  ? 93  ALA A CB  1 
ATOM 816  N N   . VAL A 1 100 ? 33.509 -16.518 5.876   1.00 66.80  ? 94  VAL A N   1 
ATOM 817  C CA  . VAL A 1 100 ? 33.116 -17.867 5.465   1.00 52.46  ? 94  VAL A CA  1 
ATOM 818  C C   . VAL A 1 100 ? 34.297 -18.738 5.065   1.00 69.84  ? 94  VAL A C   1 
ATOM 819  O O   . VAL A 1 100 ? 34.129 -19.953 4.891   1.00 73.27  ? 94  VAL A O   1 
ATOM 820  C CB  . VAL A 1 100 ? 32.085 -17.790 4.321   1.00 54.12  ? 94  VAL A CB  1 
ATOM 821  C CG1 . VAL A 1 100 ? 32.772 -17.521 2.993   1.00 71.35  ? 94  VAL A CG1 1 
ATOM 822  C CG2 . VAL A 1 100 ? 31.242 -19.061 4.263   1.00 42.87  ? 94  VAL A CG2 1 
ATOM 823  N N   . GLU A 1 101 ? 35.497 -18.166 4.938   1.00 80.12  ? 95  GLU A N   1 
ATOM 824  C CA  . GLU A 1 101 ? 36.668 -18.945 4.549   1.00 68.74  ? 95  GLU A CA  1 
ATOM 825  C C   . GLU A 1 101 ? 37.129 -19.921 5.626   1.00 71.35  ? 95  GLU A C   1 
ATOM 826  O O   . GLU A 1 101 ? 37.940 -20.807 5.328   1.00 56.62  ? 95  GLU A O   1 
ATOM 827  C CB  . GLU A 1 101 ? 37.816 -18.007 4.174   1.00 77.82  ? 95  GLU A CB  1 
ATOM 828  C CG  . GLU A 1 101 ? 38.346 -17.172 5.333   1.00 85.32  ? 95  GLU A CG  1 
ATOM 829  C CD  . GLU A 1 101 ? 39.521 -16.295 4.935   1.00 99.09  ? 95  GLU A CD  1 
ATOM 830  O OE1 . GLU A 1 101 ? 39.923 -16.332 3.752   1.00 121.57 ? 95  GLU A OE1 1 
ATOM 831  O OE2 . GLU A 1 101 ? 40.039 -15.565 5.806   1.00 88.80  ? 95  GLU A OE2 1 
ATOM 832  N N   . SER A 1 102 ? 36.643 -19.779 6.856   1.00 68.10  ? 96  SER A N   1 
ATOM 833  C CA  . SER A 1 102 ? 36.963 -20.675 7.960   1.00 59.77  ? 96  SER A CA  1 
ATOM 834  C C   . SER A 1 102 ? 35.696 -21.257 8.563   1.00 52.80  ? 96  SER A C   1 
ATOM 835  O O   . SER A 1 102 ? 35.511 -21.267 9.780   1.00 66.58  ? 96  SER A O   1 
ATOM 836  C CB  . SER A 1 102 ? 37.761 -19.953 9.037   1.00 66.24  ? 96  SER A CB  1 
ATOM 837  O OG  . SER A 1 102 ? 37.054 -18.814 9.496   1.00 86.63  ? 96  SER A OG  1 
ATOM 838  N N   . TYR A 1 103 ? 34.801 -21.740 7.716   1.00 52.63  ? 97  TYR A N   1 
ATOM 839  C CA  . TYR A 1 103 ? 33.531 -22.287 8.162   1.00 53.68  ? 97  TYR A CA  1 
ATOM 840  C C   . TYR A 1 103 ? 33.619 -23.804 8.146   1.00 61.72  ? 97  TYR A C   1 
ATOM 841  O O   . TYR A 1 103 ? 34.090 -24.395 7.169   1.00 61.40  ? 97  TYR A O   1 
ATOM 842  C CB  . TYR A 1 103 ? 32.393 -21.801 7.267   1.00 62.81  ? 97  TYR A CB  1 
ATOM 843  C CG  . TYR A 1 103 ? 31.558 -20.685 7.850   1.00 61.47  ? 97  TYR A CG  1 
ATOM 844  C CD1 . TYR A 1 103 ? 32.125 -19.726 8.675   1.00 66.56  ? 97  TYR A CD1 1 
ATOM 845  C CD2 . TYR A 1 103 ? 30.207 -20.569 7.542   1.00 67.31  ? 97  TYR A CD2 1 
ATOM 846  C CE1 . TYR A 1 103 ? 31.366 -18.696 9.201   1.00 75.03  ? 97  TYR A CE1 1 
ATOM 847  C CE2 . TYR A 1 103 ? 29.440 -19.541 8.062   1.00 42.27  ? 97  TYR A CE2 1 
ATOM 848  C CZ  . TYR A 1 103 ? 30.024 -18.609 8.889   1.00 54.03  ? 97  TYR A CZ  1 
ATOM 849  O OH  . TYR A 1 103 ? 29.261 -17.587 9.406   1.00 62.19  ? 97  TYR A OH  1 
ATOM 850  N N   . SER A 1 104 ? 33.189 -24.426 9.237   1.00 68.81  ? 98  SER A N   1 
ATOM 851  C CA  . SER A 1 104 ? 33.150 -25.875 9.308   1.00 65.78  ? 98  SER A CA  1 
ATOM 852  C C   . SER A 1 104 ? 32.114 -26.418 8.323   1.00 68.56  ? 98  SER A C   1 
ATOM 853  O O   . SER A 1 104 ? 31.277 -25.684 7.790   1.00 76.53  ? 98  SER A O   1 
ATOM 854  C CB  . SER A 1 104 ? 32.852 -26.321 10.740  1.00 62.18  ? 98  SER A CB  1 
ATOM 855  O OG  . SER A 1 104 ? 31.603 -25.828 11.190  1.00 55.12  ? 98  SER A OG  1 
ATOM 856  N N   . ALA A 1 105 ? 32.186 -27.729 8.073   1.00 67.39  ? 99  ALA A N   1 
ATOM 857  C CA  . ALA A 1 105 ? 31.302 -28.342 7.086   1.00 64.43  ? 99  ALA A CA  1 
ATOM 858  C C   . ALA A 1 105 ? 29.842 -28.229 7.499   1.00 64.50  ? 99  ALA A C   1 
ATOM 859  O O   . ALA A 1 105 ? 28.966 -28.008 6.657   1.00 64.15  ? 99  ALA A O   1 
ATOM 860  C CB  . ALA A 1 105 ? 31.682 -29.807 6.874   1.00 52.86  ? 99  ALA A CB  1 
ATOM 861  N N   . ASN A 1 106 ? 29.560 -28.384 8.792   1.00 56.46  ? 100 ASN A N   1 
ATOM 862  C CA  . ASN A 1 106 ? 28.183 -28.298 9.262   1.00 55.49  ? 100 ASN A CA  1 
ATOM 863  C C   . ASN A 1 106 ? 27.638 -26.884 9.108   1.00 69.93  ? 100 ASN A C   1 
ATOM 864  O O   . ASN A 1 106 ? 26.486 -26.689 8.701   1.00 77.13  ? 100 ASN A O   1 
ATOM 865  C CB  . ASN A 1 106 ? 28.109 -28.743 10.721  1.00 53.37  ? 100 ASN A CB  1 
ATOM 866  C CG  . ASN A 1 106 ? 28.525 -30.182 10.906  1.00 86.76  ? 100 ASN A CG  1 
ATOM 867  O OD1 . ASN A 1 106 ? 28.667 -30.922 9.934   1.00 116.36 ? 100 ASN A OD1 1 
ATOM 868  N ND2 . ASN A 1 106 ? 28.732 -30.588 12.155  1.00 73.23  ? 100 ASN A ND2 1 
ATOM 869  N N   . GLU A 1 107 ? 28.466 -25.888 9.423   1.00 67.21  ? 101 GLU A N   1 
ATOM 870  C CA  . GLU A 1 107 ? 28.044 -24.496 9.364   1.00 58.92  ? 101 GLU A CA  1 
ATOM 871  C C   . GLU A 1 107 ? 27.733 -24.088 7.927   1.00 74.30  ? 101 GLU A C   1 
ATOM 872  O O   . GLU A 1 107 ? 26.683 -23.495 7.647   1.00 81.73  ? 101 GLU A O   1 
ATOM 873  C CB  . GLU A 1 107 ? 29.146 -23.634 9.985   1.00 49.87  ? 101 GLU A CB  1 
ATOM 874  C CG  . GLU A 1 107 ? 28.807 -22.193 10.258  1.00 76.11  ? 101 GLU A CG  1 
ATOM 875  C CD  . GLU A 1 107 ? 29.937 -21.498 10.991  1.00 96.23  ? 101 GLU A CD  1 
ATOM 876  O OE1 . GLU A 1 107 ? 31.034 -22.090 11.077  1.00 84.83  ? 101 GLU A OE1 1 
ATOM 877  O OE2 . GLU A 1 107 ? 29.732 -20.378 11.498  1.00 113.63 ? 101 GLU A OE2 1 
ATOM 878  N N   . MET A 1 108 ? 28.622 -24.437 6.992   1.00 66.17  ? 102 MET A N   1 
ATOM 879  C CA  . MET A 1 108 ? 28.363 -24.188 5.576   1.00 57.57  ? 102 MET A CA  1 
ATOM 880  C C   . MET A 1 108 ? 27.161 -24.976 5.079   1.00 61.89  ? 102 MET A C   1 
ATOM 881  O O   . MET A 1 108 ? 26.393 -24.486 4.245   1.00 63.80  ? 102 MET A O   1 
ATOM 882  C CB  . MET A 1 108 ? 29.594 -24.549 4.749   1.00 65.77  ? 102 MET A CB  1 
ATOM 883  C CG  . MET A 1 108 ? 30.763 -23.636 4.966   1.00 62.26  ? 102 MET A CG  1 
ATOM 884  S SD  . MET A 1 108 ? 32.128 -23.950 3.838   1.00 166.17 ? 102 MET A SD  1 
ATOM 885  C CE  . MET A 1 108 ? 32.590 -25.614 4.325   1.00 87.00  ? 102 MET A CE  1 
ATOM 886  N N   . GLN A 1 109 ? 27.008 -26.216 5.546   1.00 65.28  ? 103 GLN A N   1 
ATOM 887  C CA  . GLN A 1 109 ? 25.859 -27.026 5.162   1.00 65.13  ? 103 GLN A CA  1 
ATOM 888  C C   . GLN A 1 109 ? 24.564 -26.311 5.516   1.00 70.11  ? 103 GLN A C   1 
ATOM 889  O O   . GLN A 1 109 ? 23.667 -26.174 4.678   1.00 73.31  ? 103 GLN A O   1 
ATOM 890  C CB  . GLN A 1 109 ? 25.932 -28.387 5.857   1.00 64.98  ? 103 GLN A CB  1 
ATOM 891  C CG  . GLN A 1 109 ? 24.780 -29.339 5.553   1.00 66.31  ? 103 GLN A CG  1 
ATOM 892  C CD  . GLN A 1 109 ? 24.698 -29.700 4.087   1.00 74.72  ? 103 GLN A CD  1 
ATOM 893  O OE1 . GLN A 1 109 ? 25.322 -30.662 3.641   1.00 83.70  ? 103 GLN A OE1 1 
ATOM 894  N NE2 . GLN A 1 109 ? 23.921 -28.936 3.328   1.00 97.12  ? 103 GLN A NE2 1 
ATOM 895  N N   . ASP A 1 110 ? 24.462 -25.831 6.757   1.00 63.89  ? 104 ASP A N   1 
ATOM 896  C CA  . ASP A 1 110 ? 23.269 -25.106 7.179   1.00 73.77  ? 104 ASP A CA  1 
ATOM 897  C C   . ASP A 1 110 ? 23.087 -23.826 6.372   1.00 72.58  ? 104 ASP A C   1 
ATOM 898  O O   . ASP A 1 110 ? 21.969 -23.500 5.957   1.00 78.34  ? 104 ASP A O   1 
ATOM 899  C CB  . ASP A 1 110 ? 23.344 -24.789 8.673   1.00 90.07  ? 104 ASP A CB  1 
ATOM 900  C CG  . ASP A 1 110 ? 23.140 -26.015 9.540   1.00 92.89  ? 104 ASP A CG  1 
ATOM 901  O OD1 . ASP A 1 110 ? 22.531 -26.997 9.060   1.00 78.50  ? 104 ASP A OD1 1 
ATOM 902  O OD2 . ASP A 1 110 ? 23.569 -25.987 10.711  1.00 104.07 ? 104 ASP A OD2 1 
ATOM 903  N N   . LEU A 1 111 ? 24.177 -23.085 6.147   1.00 63.01  ? 105 LEU A N   1 
ATOM 904  C CA  . LEU A 1 111 ? 24.099 -21.838 5.385   1.00 57.75  ? 105 LEU A CA  1 
ATOM 905  C C   . LEU A 1 111 ? 23.530 -22.071 3.985   1.00 45.44  ? 105 LEU A C   1 
ATOM 906  O O   . LEU A 1 111 ? 22.564 -21.411 3.571   1.00 46.06  ? 105 LEU A O   1 
ATOM 907  C CB  . LEU A 1 111 ? 25.491 -21.202 5.313   1.00 52.73  ? 105 LEU A CB  1 
ATOM 908  C CG  . LEU A 1 111 ? 25.723 -19.939 4.482   1.00 55.69  ? 105 LEU A CG  1 
ATOM 909  C CD1 . LEU A 1 111 ? 24.945 -18.772 5.060   1.00 48.06  ? 105 LEU A CD1 1 
ATOM 910  C CD2 . LEU A 1 111 ? 27.211 -19.617 4.429   1.00 48.91  ? 105 LEU A CD2 1 
ATOM 911  N N   . SER A 1 112 ? 24.111 -23.018 3.244   1.00 51.24  ? 106 SER A N   1 
ATOM 912  C CA  . SER A 1 112 ? 23.669 -23.267 1.874   1.00 54.58  ? 106 SER A CA  1 
ATOM 913  C C   . SER A 1 112 ? 22.277 -23.879 1.835   1.00 52.49  ? 106 SER A C   1 
ATOM 914  O O   . SER A 1 112 ? 21.500 -23.582 0.920   1.00 57.68  ? 106 SER A O   1 
ATOM 915  C CB  . SER A 1 112 ? 24.663 -24.171 1.142   1.00 45.65  ? 106 SER A CB  1 
ATOM 916  O OG  . SER A 1 112 ? 24.824 -25.416 1.796   1.00 73.62  ? 106 SER A OG  1 
ATOM 917  N N   . ARG A 1 113 ? 21.937 -24.721 2.814   1.00 46.84  ? 107 ARG A N   1 
ATOM 918  C CA  . ARG A 1 113 ? 20.582 -25.255 2.897   1.00 58.61  ? 107 ARG A CA  1 
ATOM 919  C C   . ARG A 1 113 ? 19.566 -24.134 3.065   1.00 50.73  ? 107 ARG A C   1 
ATOM 920  O O   . ARG A 1 113 ? 18.520 -24.116 2.402   1.00 55.88  ? 107 ARG A O   1 
ATOM 921  C CB  . ARG A 1 113 ? 20.492 -26.243 4.059   1.00 78.98  ? 107 ARG A CB  1 
ATOM 922  C CG  . ARG A 1 113 ? 19.088 -26.687 4.412   1.00 97.78  ? 107 ARG A CG  1 
ATOM 923  C CD  . ARG A 1 113 ? 19.118 -27.593 5.634   1.00 107.59 ? 107 ARG A CD  1 
ATOM 924  N NE  . ARG A 1 113 ? 19.762 -26.958 6.779   1.00 109.70 ? 107 ARG A NE  1 
ATOM 925  C CZ  . ARG A 1 113 ? 19.240 -25.965 7.487   1.00 106.74 ? 107 ARG A CZ  1 
ATOM 926  N NH1 . ARG A 1 113 ? 18.048 -25.463 7.202   1.00 95.74  ? 107 ARG A NH1 1 
ATOM 927  N NH2 . ARG A 1 113 ? 19.925 -25.470 8.513   1.00 102.82 ? 107 ARG A NH2 1 
ATOM 928  N N   . SER A 1 114 ? 19.865 -23.179 3.949   1.00 42.79  ? 108 SER A N   1 
ATOM 929  C CA  . SER A 1 114 ? 18.945 -22.074 4.184   1.00 41.10  ? 108 SER A CA  1 
ATOM 930  C C   . SER A 1 114 ? 18.806 -21.198 2.945   1.00 58.11  ? 108 SER A C   1 
ATOM 931  O O   . SER A 1 114 ? 17.700 -20.758 2.605   1.00 61.10  ? 108 SER A O   1 
ATOM 932  C CB  . SER A 1 114 ? 19.415 -21.253 5.383   1.00 46.16  ? 108 SER A CB  1 
ATOM 933  O OG  . SER A 1 114 ? 19.382 -22.031 6.566   1.00 51.24  ? 108 SER A OG  1 
ATOM 934  N N   . TYR A 1 115 ? 19.913 -20.939 2.248   1.00 57.95  ? 109 TYR A N   1 
ATOM 935  C CA  . TYR A 1 115 ? 19.809 -20.183 1.002   1.00 42.00  ? 109 TYR A CA  1 
ATOM 936  C C   . TYR A 1 115 ? 18.944 -20.918 -0.020  1.00 55.24  ? 109 TYR A C   1 
ATOM 937  O O   . TYR A 1 115 ? 18.075 -20.315 -0.665  1.00 63.69  ? 109 TYR A O   1 
ATOM 938  C CB  . TYR A 1 115 ? 21.195 -19.897 0.424   1.00 20.95  ? 109 TYR A CB  1 
ATOM 939  C CG  . TYR A 1 115 ? 21.140 -18.879 -0.687  1.00 18.13  ? 109 TYR A CG  1 
ATOM 940  C CD1 . TYR A 1 115 ? 21.230 -17.523 -0.414  1.00 27.77  ? 109 TYR A CD1 1 
ATOM 941  C CD2 . TYR A 1 115 ? 20.972 -19.273 -2.007  1.00 26.85  ? 109 TYR A CD2 1 
ATOM 942  C CE1 . TYR A 1 115 ? 21.167 -16.590 -1.430  1.00 43.18  ? 109 TYR A CE1 1 
ATOM 943  C CE2 . TYR A 1 115 ? 20.907 -18.349 -3.028  1.00 34.51  ? 109 TYR A CE2 1 
ATOM 944  C CZ  . TYR A 1 115 ? 21.005 -17.009 -2.734  1.00 43.65  ? 109 TYR A CZ  1 
ATOM 945  O OH  . TYR A 1 115 ? 20.942 -16.085 -3.750  1.00 41.50  ? 109 TYR A OH  1 
ATOM 946  N N   . ASP A 1 116 ? 19.170 -22.226 -0.182  1.00 54.68  ? 110 ASP A N   1 
ATOM 947  C CA  . ASP A 1 116 ? 18.443 -22.985 -1.196  1.00 50.35  ? 110 ASP A CA  1 
ATOM 948  C C   . ASP A 1 116 ? 16.950 -23.025 -0.899  1.00 53.11  ? 110 ASP A C   1 
ATOM 949  O O   . ASP A 1 116 ? 16.126 -22.949 -1.818  1.00 61.57  ? 110 ASP A O   1 
ATOM 950  C CB  . ASP A 1 116 ? 19.006 -24.404 -1.297  1.00 45.41  ? 110 ASP A CB  1 
ATOM 951  C CG  . ASP A 1 116 ? 20.406 -24.430 -1.870  1.00 53.04  ? 110 ASP A CG  1 
ATOM 952  O OD1 . ASP A 1 116 ? 20.887 -23.362 -2.307  1.00 38.89  ? 110 ASP A OD1 1 
ATOM 953  O OD2 . ASP A 1 116 ? 21.027 -25.512 -1.883  1.00 80.56  ? 110 ASP A OD2 1 
ATOM 954  N N   . ILE A 1 117 ? 16.579 -23.132 0.379   1.00 54.14  ? 111 ILE A N   1 
ATOM 955  C CA  . ILE A 1 117 ? 15.159 -23.168 0.720   1.00 61.09  ? 111 ILE A CA  1 
ATOM 956  C C   . ILE A 1 117 ? 14.530 -21.784 0.571   1.00 62.22  ? 111 ILE A C   1 
ATOM 957  O O   . ILE A 1 117 ? 13.403 -21.653 0.077   1.00 60.92  ? 111 ILE A O   1 
ATOM 958  C CB  . ILE A 1 117 ? 14.959 -23.742 2.135   1.00 56.16  ? 111 ILE A CB  1 
ATOM 959  C CG1 . ILE A 1 117 ? 15.592 -22.815 3.170   1.00 50.77  ? 111 ILE A CG1 1 
ATOM 960  C CG2 . ILE A 1 117 ? 15.519 -25.148 2.214   1.00 68.06  ? 111 ILE A CG2 1 
ATOM 961  C CD1 . ILE A 1 117 ? 15.613 -23.325 4.562   1.00 71.57  ? 111 ILE A CD1 1 
ATOM 962  N N   . LEU A 1 118 ? 15.250 -20.728 0.968   1.00 60.86  ? 112 LEU A N   1 
ATOM 963  C CA  . LEU A 1 118 ? 14.660 -19.394 0.930   1.00 50.06  ? 112 LEU A CA  1 
ATOM 964  C C   . LEU A 1 118 ? 14.478 -18.914 -0.503  1.00 55.47  ? 112 LEU A C   1 
ATOM 965  O O   . LEU A 1 118 ? 13.479 -18.257 -0.820  1.00 50.61  ? 112 LEU A O   1 
ATOM 966  C CB  . LEU A 1 118 ? 15.525 -18.414 1.720   1.00 50.55  ? 112 LEU A CB  1 
ATOM 967  C CG  . LEU A 1 118 ? 15.002 -16.982 1.781   1.00 68.02  ? 112 LEU A CG  1 
ATOM 968  C CD1 . LEU A 1 118 ? 13.594 -16.966 2.354   1.00 72.77  ? 112 LEU A CD1 1 
ATOM 969  C CD2 . LEU A 1 118 ? 15.927 -16.101 2.606   1.00 45.37  ? 112 LEU A CD2 1 
ATOM 970  N N   . GLU A 1 119 ? 15.437 -19.227 -1.379  1.00 68.20  ? 113 GLU A N   1 
ATOM 971  C CA  . GLU A 1 119 ? 15.298 -18.881 -2.789  1.00 70.27  ? 113 GLU A CA  1 
ATOM 972  C C   . GLU A 1 119 ? 14.015 -19.461 -3.366  1.00 75.23  ? 113 GLU A C   1 
ATOM 973  O O   . GLU A 1 119 ? 13.235 -18.756 -4.015  1.00 77.35  ? 113 GLU A O   1 
ATOM 974  C CB  . GLU A 1 119 ? 16.514 -19.384 -3.571  1.00 60.93  ? 113 GLU A CB  1 
ATOM 975  C CG  . GLU A 1 119 ? 16.371 -19.261 -5.081  1.00 92.20  ? 113 GLU A CG  1 
ATOM 976  C CD  . GLU A 1 119 ? 17.635 -19.647 -5.825  1.00 111.92 ? 113 GLU A CD  1 
ATOM 977  O OE1 . GLU A 1 119 ? 18.655 -19.935 -5.162  1.00 106.37 ? 113 GLU A OE1 1 
ATOM 978  O OE2 . GLU A 1 119 ? 17.609 -19.661 -7.075  1.00 97.78  ? 113 GLU A OE2 1 
ATOM 979  N N   . LYS A 1 120 ? 13.780 -20.752 -3.125  1.00 69.57  ? 114 LYS A N   1 
ATOM 980  C CA  . LYS A 1 120 ? 12.592 -21.416 -3.640  1.00 77.14  ? 114 LYS A CA  1 
ATOM 981  C C   . LYS A 1 120 ? 11.321 -20.946 -2.947  1.00 76.76  ? 114 LYS A C   1 
ATOM 982  O O   . LYS A 1 120 ? 10.240 -21.060 -3.533  1.00 81.22  ? 114 LYS A O   1 
ATOM 983  C CB  . LYS A 1 120 ? 12.752 -22.931 -3.504  1.00 74.84  ? 114 LYS A CB  1 
ATOM 984  C CG  . LYS A 1 120 ? 13.839 -23.484 -4.402  1.00 96.35  ? 114 LYS A CG  1 
ATOM 985  C CD  . LYS A 1 120 ? 14.060 -24.973 -4.206  1.00 110.77 ? 114 LYS A CD  1 
ATOM 986  C CE  . LYS A 1 120 ? 15.143 -25.485 -5.145  1.00 83.58  ? 114 LYS A CE  1 
ATOM 987  N NZ  . LYS A 1 120 ? 15.398 -26.941 -4.984  1.00 88.26  ? 114 LYS A NZ  1 
ATOM 988  N N   . GLU A 1 121 ? 11.418 -20.431 -1.718  1.00 69.11  ? 115 GLU A N   1 
ATOM 989  C CA  . GLU A 1 121 ? 10.244 -19.827 -1.095  1.00 71.78  ? 115 GLU A CA  1 
ATOM 990  C C   . GLU A 1 121 ? 9.881  -18.507 -1.762  1.00 62.42  ? 115 GLU A C   1 
ATOM 991  O O   . GLU A 1 121 ? 8.707  -18.251 -2.051  1.00 57.25  ? 115 GLU A O   1 
ATOM 992  C CB  . GLU A 1 121 ? 10.466 -19.617 0.402   1.00 87.64  ? 115 GLU A CB  1 
ATOM 993  C CG  . GLU A 1 121 ? 10.545 -20.887 1.210   1.00 100.82 ? 115 GLU A CG  1 
ATOM 994  C CD  . GLU A 1 121 ? 10.991 -20.637 2.633   1.00 127.35 ? 115 GLU A CD  1 
ATOM 995  O OE1 . GLU A 1 121 ? 11.197 -19.461 2.998   1.00 114.49 ? 115 GLU A OE1 1 
ATOM 996  O OE2 . GLU A 1 121 ? 11.123 -21.617 3.393   1.00 121.53 ? 115 GLU A OE2 1 
ATOM 997  N N   . VAL A 1 122 ? 10.874 -17.645 -2.011  1.00 64.72  ? 116 VAL A N   1 
ATOM 998  C CA  . VAL A 1 122 ? 10.580 -16.311 -2.525  1.00 67.38  ? 116 VAL A CA  1 
ATOM 999  C C   . VAL A 1 122 ? 10.554 -16.257 -4.046  1.00 64.23  ? 116 VAL A C   1 
ATOM 1000 O O   . VAL A 1 122 ? 10.318 -15.182 -4.614  1.00 69.15  ? 116 VAL A O   1 
ATOM 1001 C CB  . VAL A 1 122 ? 11.583 -15.275 -1.978  1.00 77.24  ? 116 VAL A CB  1 
ATOM 1002 C CG1 . VAL A 1 122 ? 11.599 -15.307 -0.452  1.00 79.21  ? 116 VAL A CG1 1 
ATOM 1003 C CG2 . VAL A 1 122 ? 12.961 -15.514 -2.551  1.00 85.55  ? 116 VAL A CG2 1 
ATOM 1004 N N   . CYS A 1 123 ? 10.782 -17.379 -4.728  1.00 63.23  ? 117 CYS A N   1 
ATOM 1005 C CA  . CYS A 1 123 ? 10.656 -17.386 -6.179  1.00 57.42  ? 117 CYS A CA  1 
ATOM 1006 C C   . CYS A 1 123 ? 9.209  -17.494 -6.641  1.00 62.84  ? 117 CYS A C   1 
ATOM 1007 O O   . CYS A 1 123 ? 8.918  -17.176 -7.799  1.00 77.73  ? 117 CYS A O   1 
ATOM 1008 C CB  . CYS A 1 123 ? 11.486 -18.524 -6.781  1.00 63.31  ? 117 CYS A CB  1 
ATOM 1009 S SG  . CYS A 1 123 ? 13.227 -18.100 -7.047  1.00 90.51  ? 117 CYS A SG  1 
ATOM 1010 N N   . LYS A 1 124 ? 8.295  -17.906 -5.763  1.00 69.46  ? 118 LYS A N   1 
ATOM 1011 C CA  . LYS A 1 124 ? 6.887  -18.050 -6.106  1.00 68.45  ? 118 LYS A CA  1 
ATOM 1012 C C   . LYS A 1 124 ? 6.036  -16.859 -5.682  1.00 67.11  ? 118 LYS A C   1 
ATOM 1013 O O   . LYS A 1 124 ? 4.847  -16.818 -6.017  1.00 61.72  ? 118 LYS A O   1 
ATOM 1014 C CB  . LYS A 1 124 ? 6.330  -19.335 -5.484  1.00 70.44  ? 118 LYS A CB  1 
ATOM 1015 C CG  . LYS A 1 124 ? 6.560  -19.435 -3.990  1.00 74.86  ? 118 LYS A CG  1 
ATOM 1016 C CD  . LYS A 1 124 ? 5.860  -20.642 -3.400  1.00 85.41  ? 118 LYS A CD  1 
ATOM 1017 C CE  . LYS A 1 124 ? 6.095  -20.721 -1.903  1.00 84.56  ? 118 LYS A CE  1 
ATOM 1018 N NZ  . LYS A 1 124 ? 5.392  -21.883 -1.299  1.00 102.18 ? 118 LYS A NZ  1 
ATOM 1019 N N   . THR A 1 125 ? 6.608  -15.899 -4.957  1.00 69.30  ? 119 THR A N   1 
ATOM 1020 C CA  . THR A 1 125 ? 5.942  -14.640 -4.653  1.00 64.38  ? 119 THR A CA  1 
ATOM 1021 C C   . THR A 1 125 ? 6.171  -13.580 -5.722  1.00 69.32  ? 119 THR A C   1 
ATOM 1022 O O   . THR A 1 125 ? 5.560  -12.508 -5.649  1.00 74.21  ? 119 THR A O   1 
ATOM 1023 C CB  . THR A 1 125 ? 6.418  -14.099 -3.299  1.00 54.26  ? 119 THR A CB  1 
ATOM 1024 O OG1 . THR A 1 125 ? 7.841  -13.934 -3.321  1.00 55.54  ? 119 THR A OG1 1 
ATOM 1025 C CG2 . THR A 1 125 ? 6.047  -15.064 -2.190  1.00 65.57  ? 119 THR A CG2 1 
ATOM 1026 N N   . PHE A 1 126 ? 7.046  -13.856 -6.697  1.00 47.97  ? 120 PHE A N   1 
ATOM 1027 C CA  . PHE A 1 126 ? 7.382  -13.004 -7.832  1.00 46.48  ? 120 PHE A CA  1 
ATOM 1028 C C   . PHE A 1 126 ? 6.117  -12.456 -8.481  1.00 62.71  ? 120 PHE A C   1 
ATOM 1029 O O   . PHE A 1 126 ? 5.147  -13.202 -8.669  1.00 62.82  ? 120 PHE A O   1 
ATOM 1030 C CB  . PHE A 1 126 ? 8.212  -13.805 -8.840  1.00 50.65  ? 120 PHE A CB  1 
ATOM 1031 C CG  . PHE A 1 126 ? 8.724  -12.996 -10.006 1.00 59.74  ? 120 PHE A CG  1 
ATOM 1032 C CD1 . PHE A 1 126 ? 9.931  -12.320 -9.931  1.00 51.61  ? 120 PHE A CD1 1 
ATOM 1033 C CD2 . PHE A 1 126 ? 8.011  -12.935 -11.190 1.00 60.71  ? 120 PHE A CD2 1 
ATOM 1034 C CE1 . PHE A 1 126 ? 10.404 -11.584 -11.011 1.00 40.25  ? 120 PHE A CE1 1 
ATOM 1035 C CE2 . PHE A 1 126 ? 8.479  -12.202 -12.270 1.00 60.53  ? 120 PHE A CE2 1 
ATOM 1036 C CZ  . PHE A 1 126 ? 9.677  -11.526 -12.180 1.00 47.34  ? 120 PHE A CZ  1 
ATOM 1037 N N   . PRO A 1 127 ? 6.079  -11.163 -8.836  1.00 78.17  ? 121 PRO A N   1 
ATOM 1038 C CA  . PRO A 1 127 ? 7.141  -10.154 -8.705  1.00 61.54  ? 121 PRO A CA  1 
ATOM 1039 C C   . PRO A 1 127 ? 7.231  -9.543  -7.307  1.00 65.28  ? 121 PRO A C   1 
ATOM 1040 O O   . PRO A 1 127 ? 8.085  -8.697  -7.058  1.00 81.73  ? 121 PRO A O   1 
ATOM 1041 C CB  . PRO A 1 127 ? 6.736  -9.107  -9.750  1.00 57.70  ? 121 PRO A CB  1 
ATOM 1042 C CG  . PRO A 1 127 ? 5.239  -9.156  -9.729  1.00 72.46  ? 121 PRO A CG  1 
ATOM 1043 C CD  . PRO A 1 127 ? 4.897  -10.615 -9.527  1.00 83.53  ? 121 PRO A CD  1 
ATOM 1044 N N   . ASN A 1 128 ? 6.368  -9.939  -6.377  1.00 52.23  ? 122 ASN A N   1 
ATOM 1045 C CA  . ASN A 1 128 ? 6.418  -9.405  -5.025  1.00 60.21  ? 122 ASN A CA  1 
ATOM 1046 C C   . ASN A 1 128 ? 7.481  -10.120 -4.202  1.00 64.96  ? 122 ASN A C   1 
ATOM 1047 O O   . ASN A 1 128 ? 7.816  -11.283 -4.450  1.00 59.61  ? 122 ASN A O   1 
ATOM 1048 C CB  . ASN A 1 128 ? 5.055  -9.526  -4.347  1.00 75.01  ? 122 ASN A CB  1 
ATOM 1049 C CG  . ASN A 1 128 ? 3.986  -8.722  -5.051  1.00 68.05  ? 122 ASN A CG  1 
ATOM 1050 O OD1 . ASN A 1 128 ? 4.287  -7.836  -5.851  1.00 63.01  ? 122 ASN A OD1 1 
ATOM 1051 N ND2 . ASN A 1 128 ? 2.727  -9.026  -4.760  1.00 68.41  ? 122 ASN A ND2 1 
ATOM 1052 N N   . PHE A 1 129 ? 8.012  -9.409  -3.213  1.00 77.79  ? 123 PHE A N   1 
ATOM 1053 C CA  . PHE A 1 129 ? 9.120  -9.898  -2.409  1.00 77.40  ? 123 PHE A CA  1 
ATOM 1054 C C   . PHE A 1 129 ? 8.953  -9.428  -0.972  1.00 76.39  ? 123 PHE A C   1 
ATOM 1055 O O   . PHE A 1 129 ? 8.376  -8.364  -0.723  1.00 78.67  ? 123 PHE A O   1 
ATOM 1056 C CB  . PHE A 1 129 ? 10.465 -9.393  -2.952  1.00 64.92  ? 123 PHE A CB  1 
ATOM 1057 C CG  . PHE A 1 129 ? 10.774 -9.863  -4.341  1.00 63.54  ? 123 PHE A CG  1 
ATOM 1058 C CD1 . PHE A 1 129 ? 10.932 -11.210 -4.619  1.00 65.75  ? 123 PHE A CD1 1 
ATOM 1059 C CD2 . PHE A 1 129 ? 10.897 -8.948  -5.375  1.00 39.76  ? 123 PHE A CD2 1 
ATOM 1060 C CE1 . PHE A 1 129 ? 11.213 -11.637 -5.902  1.00 54.77  ? 123 PHE A CE1 1 
ATOM 1061 C CE2 . PHE A 1 129 ? 11.178 -9.367  -6.656  1.00 39.97  ? 123 PHE A CE2 1 
ATOM 1062 C CZ  . PHE A 1 129 ? 11.336 -10.709 -6.922  1.00 48.92  ? 123 PHE A CZ  1 
ATOM 1063 N N   . PRO A 1 130 ? 9.456  -10.196 -0.012  1.00 63.88  ? 124 PRO A N   1 
ATOM 1064 C CA  . PRO A 1 130 ? 9.409  -9.763  1.386   1.00 62.55  ? 124 PRO A CA  1 
ATOM 1065 C C   . PRO A 1 130 ? 10.491 -8.741  1.702   1.00 62.94  ? 124 PRO A C   1 
ATOM 1066 O O   . PRO A 1 130 ? 11.530 -8.661  1.044   1.00 68.88  ? 124 PRO A O   1 
ATOM 1067 C CB  . PRO A 1 130 ? 9.643  -11.064 2.157   1.00 61.42  ? 124 PRO A CB  1 
ATOM 1068 C CG  . PRO A 1 130 ? 10.473 -11.894 1.230   1.00 46.63  ? 124 PRO A CG  1 
ATOM 1069 C CD  . PRO A 1 130 ? 9.983  -11.565 -0.155  1.00 44.22  ? 124 PRO A CD  1 
ATOM 1070 N N   . SER A 1 131 ? 10.223 -7.947  2.736   1.00 64.51  ? 125 SER A N   1 
ATOM 1071 C CA  . SER A 1 131 ? 11.189 -6.969  3.210   1.00 71.10  ? 125 SER A CA  1 
ATOM 1072 C C   . SER A 1 131 ? 12.271 -7.663  4.038   1.00 64.77  ? 125 SER A C   1 
ATOM 1073 O O   . SER A 1 131 ? 12.272 -8.885  4.211   1.00 75.43  ? 125 SER A O   1 
ATOM 1074 C CB  . SER A 1 131 ? 10.488 -5.869  4.005   1.00 67.31  ? 125 SER A CB  1 
ATOM 1075 O OG  . SER A 1 131 ? 9.914  -6.372  5.199   1.00 68.86  ? 125 SER A OG  1 
ATOM 1076 N N   . ILE A 1 132 ? 13.207 -6.870  4.564   1.00 44.77  ? 126 ILE A N   1 
ATOM 1077 C CA  . ILE A 1 132 ? 14.364 -7.439  5.253   1.00 53.32  ? 126 ILE A CA  1 
ATOM 1078 C C   . ILE A 1 132 ? 13.935 -8.122  6.548   1.00 73.00  ? 126 ILE A C   1 
ATOM 1079 O O   . ILE A 1 132 ? 14.364 -9.242  6.852   1.00 73.37  ? 126 ILE A O   1 
ATOM 1080 C CB  . ILE A 1 132 ? 15.419 -6.350  5.511   1.00 65.34  ? 126 ILE A CB  1 
ATOM 1081 C CG1 . ILE A 1 132 ? 16.029 -5.885  4.190   1.00 67.29  ? 126 ILE A CG1 1 
ATOM 1082 C CG2 . ILE A 1 132 ? 16.503 -6.868  6.446   1.00 67.68  ? 126 ILE A CG2 1 
ATOM 1083 C CD1 . ILE A 1 132 ? 16.859 -4.634  4.311   1.00 93.40  ? 126 ILE A CD1 1 
ATOM 1084 N N   . ASN A 1 133 ? 13.086 -7.456  7.334   1.00 67.18  ? 127 ASN A N   1 
ATOM 1085 C CA  . ASN A 1 133 ? 12.625 -8.057  8.580   1.00 56.33  ? 127 ASN A CA  1 
ATOM 1086 C C   . ASN A 1 133 ? 11.643 -9.189  8.320   1.00 66.56  ? 127 ASN A C   1 
ATOM 1087 O O   . ASN A 1 133 ? 11.588 -10.146 9.100   1.00 78.72  ? 127 ASN A O   1 
ATOM 1088 C CB  . ASN A 1 133 ? 11.994 -6.997  9.479   1.00 63.30  ? 127 ASN A CB  1 
ATOM 1089 C CG  . ASN A 1 133 ? 12.998 -5.956  9.935   1.00 90.46  ? 127 ASN A CG  1 
ATOM 1090 O OD1 . ASN A 1 133 ? 14.196 -6.229  10.023  1.00 86.64  ? 127 ASN A OD1 1 
ATOM 1091 N ND2 . ASN A 1 133 ? 12.513 -4.758  10.234  1.00 106.09 ? 127 ASN A ND2 1 
ATOM 1092 N N   . GLU A 1 134 ? 10.863 -9.101  7.239   1.00 64.86  ? 128 GLU A N   1 
ATOM 1093 C CA  . GLU A 1 134 ? 10.007 -10.223 6.866   1.00 64.91  ? 128 GLU A CA  1 
ATOM 1094 C C   . GLU A 1 134 ? 10.828 -11.417 6.402   1.00 69.64  ? 128 GLU A C   1 
ATOM 1095 O O   . GLU A 1 134 ? 10.403 -12.565 6.566   1.00 82.20  ? 128 GLU A O   1 
ATOM 1096 C CB  . GLU A 1 134 ? 9.034  -9.814  5.764   1.00 52.71  ? 128 GLU A CB  1 
ATOM 1097 C CG  . GLU A 1 134 ? 7.962  -8.840  6.216   1.00 66.63  ? 128 GLU A CG  1 
ATOM 1098 C CD  . GLU A 1 134 ? 7.075  -8.387  5.075   1.00 79.94  ? 128 GLU A CD  1 
ATOM 1099 O OE1 . GLU A 1 134 ? 7.601  -7.792  4.105   1.00 67.31  ? 128 GLU A OE1 1 
ATOM 1100 O OE2 . GLU A 1 134 ? 5.851  -8.604  5.159   1.00 93.67  ? 128 GLU A OE2 1 
ATOM 1101 N N   . MET A 1 135 ? 12.002 -11.164 5.832   1.00 64.72  ? 129 MET A N   1 
ATOM 1102 C CA  . MET A 1 135 ? 12.878 -12.208 5.329   1.00 63.47  ? 129 MET A CA  1 
ATOM 1103 C C   . MET A 1 135 ? 13.754 -12.809 6.421   1.00 72.62  ? 129 MET A C   1 
ATOM 1104 O O   . MET A 1 135 ? 14.347 -13.872 6.206   1.00 87.73  ? 129 MET A O   1 
ATOM 1105 C CB  . MET A 1 135 ? 13.730 -11.634 4.189   1.00 62.72  ? 129 MET A CB  1 
ATOM 1106 C CG  . MET A 1 135 ? 14.499 -12.632 3.353   1.00 74.43  ? 129 MET A CG  1 
ATOM 1107 S SD  . MET A 1 135 ? 15.551 -11.768 2.168   1.00 102.00 ? 129 MET A SD  1 
ATOM 1108 C CE  . MET A 1 135 ? 14.329 -10.893 1.189   1.00 61.39  ? 129 MET A CE  1 
ATOM 1109 N N   . LYS A 1 136 ? 13.834 -12.163 7.585   1.00 56.37  ? 130 LYS A N   1 
ATOM 1110 C CA  . LYS A 1 136 ? 14.478 -12.767 8.742   1.00 66.20  ? 130 LYS A CA  1 
ATOM 1111 C C   . LYS A 1 136 ? 13.619 -13.848 9.380   1.00 81.19  ? 130 LYS A C   1 
ATOM 1112 O O   . LYS A 1 136 ? 14.153 -14.703 10.095  1.00 80.40  ? 130 LYS A O   1 
ATOM 1113 C CB  . LYS A 1 136 ? 14.792 -11.703 9.795   1.00 69.60  ? 130 LYS A CB  1 
ATOM 1114 C CG  . LYS A 1 136 ? 15.970 -10.812 9.465   1.00 58.37  ? 130 LYS A CG  1 
ATOM 1115 C CD  . LYS A 1 136 ? 16.049 -9.661  10.450  1.00 60.06  ? 130 LYS A CD  1 
ATOM 1116 C CE  . LYS A 1 136 ? 17.120 -8.659  10.068  1.00 53.11  ? 130 LYS A CE  1 
ATOM 1117 N NZ  . LYS A 1 136 ? 17.001 -7.424  10.890  1.00 52.13  ? 130 LYS A NZ  1 
ATOM 1118 N N   . GLU A 1 137 ? 12.309 -13.831 9.121   1.00 89.03  ? 131 GLU A N   1 
ATOM 1119 C CA  . GLU A 1 137 ? 11.378 -14.698 9.836   1.00 94.38  ? 131 GLU A CA  1 
ATOM 1120 C C   . GLU A 1 137 ? 11.671 -16.171 9.573   1.00 105.01 ? 131 GLU A C   1 
ATOM 1121 O O   . GLU A 1 137 ? 11.713 -16.984 10.504  1.00 116.44 ? 131 GLU A O   1 
ATOM 1122 C CB  . GLU A 1 137 ? 9.947  -14.348 9.432   1.00 105.72 ? 131 GLU A CB  1 
ATOM 1123 C CG  . GLU A 1 137 ? 9.496  -12.973 9.898   1.00 103.77 ? 131 GLU A CG  1 
ATOM 1124 C CD  . GLU A 1 137 ? 8.063  -12.672 9.512   1.00 102.45 ? 131 GLU A CD  1 
ATOM 1125 O OE1 . GLU A 1 137 ? 7.414  -13.553 8.910   1.00 91.25  ? 131 GLU A OE1 1 
ATOM 1126 O OE2 . GLU A 1 137 ? 7.588  -11.553 9.801   1.00 79.48  ? 131 GLU A OE2 1 
ATOM 1127 N N   . SER A 1 138 ? 11.874 -16.536 8.305   1.00 84.15  ? 132 SER A N   1 
ATOM 1128 C CA  . SER A 1 138 ? 12.166 -17.923 7.962   1.00 96.43  ? 132 SER A CA  1 
ATOM 1129 C C   . SER A 1 138 ? 13.564 -18.354 8.388   1.00 100.37 ? 132 SER A C   1 
ATOM 1130 O O   . SER A 1 138 ? 13.845 -19.558 8.398   1.00 91.46  ? 132 SER A O   1 
ATOM 1131 C CB  . SER A 1 138 ? 11.997 -18.142 6.457   1.00 100.24 ? 132 SER A CB  1 
ATOM 1132 O OG  . SER A 1 138 ? 12.738 -17.189 5.719   1.00 97.93  ? 132 SER A OG  1 
ATOM 1133 N N   . LEU A 1 139 ? 14.435 -17.411 8.744   1.00 98.55  ? 133 LEU A N   1 
ATOM 1134 C CA  . LEU A 1 139 ? 15.806 -17.703 9.138   1.00 80.66  ? 133 LEU A CA  1 
ATOM 1135 C C   . LEU A 1 139 ? 16.015 -17.588 10.641  1.00 77.21  ? 133 LEU A C   1 
ATOM 1136 O O   . LEU A 1 139 ? 17.156 -17.669 11.109  1.00 68.23  ? 133 LEU A O   1 
ATOM 1137 C CB  . LEU A 1 139 ? 16.766 -16.763 8.411   1.00 80.16  ? 133 LEU A CB  1 
ATOM 1138 C CG  . LEU A 1 139 ? 16.702 -16.778 6.885   1.00 77.15  ? 133 LEU A CG  1 
ATOM 1139 C CD1 . LEU A 1 139 ? 17.599 -15.695 6.314   1.00 52.14  ? 133 LEU A CD1 1 
ATOM 1140 C CD2 . LEU A 1 139 ? 17.087 -18.143 6.342   1.00 81.77  ? 133 LEU A CD2 1 
ATOM 1141 N N   . MET A 1 140 ? 14.938 -17.393 11.403  1.00 98.55  ? 134 MET A N   1 
ATOM 1142 C CA  . MET A 1 140 ? 15.050 -17.209 12.845  1.00 96.35  ? 134 MET A CA  1 
ATOM 1143 C C   . MET A 1 140 ? 15.554 -18.463 13.546  1.00 93.20  ? 134 MET A C   1 
ATOM 1144 O O   . MET A 1 140 ? 16.059 -18.373 14.671  1.00 94.27  ? 134 MET A O   1 
ATOM 1145 C CB  . MET A 1 140 ? 13.689 -16.799 13.413  1.00 106.29 ? 134 MET A CB  1 
ATOM 1146 C CG  . MET A 1 140 ? 13.251 -15.385 13.032  1.00 121.44 ? 134 MET A CG  1 
ATOM 1147 S SD  . MET A 1 140 ? 11.740 -14.850 13.868  1.00 166.60 ? 134 MET A SD  1 
ATOM 1148 C CE  . MET A 1 140 ? 11.702 -13.103 13.455  1.00 109.11 ? 134 MET A CE  1 
ATOM 1149 N N   . HIS A 1 141 ? 15.438 -19.624 12.908  1.00 97.74  ? 135 HIS A N   1 
ATOM 1150 C CA  . HIS A 1 141 ? 15.797 -20.888 13.534  1.00 95.00  ? 135 HIS A CA  1 
ATOM 1151 C C   . HIS A 1 141 ? 17.291 -21.185 13.480  1.00 87.42  ? 135 HIS A C   1 
ATOM 1152 O O   . HIS A 1 141 ? 17.715 -22.228 13.990  1.00 101.54 ? 135 HIS A O   1 
ATOM 1153 C CB  . HIS A 1 141 ? 15.006 -22.024 12.880  1.00 108.00 ? 135 HIS A CB  1 
ATOM 1154 C CG  . HIS A 1 141 ? 13.532 -21.772 12.823  1.00 123.88 ? 135 HIS A CG  1 
ATOM 1155 N ND1 . HIS A 1 141 ? 12.739 -21.736 13.954  1.00 127.05 ? 135 HIS A ND1 1 
ATOM 1156 C CD2 . HIS A 1 141 ? 12.701 -21.542 11.780  1.00 128.17 ? 135 HIS A CD2 1 
ATOM 1157 C CE1 . HIS A 1 141 ? 11.490 -21.496 13.607  1.00 126.48 ? 135 HIS A CE1 1 
ATOM 1158 N NE2 . HIS A 1 141 ? 11.438 -21.374 12.290  1.00 133.35 ? 135 HIS A NE2 1 
ATOM 1159 N N   . LEU A 1 142 ? 18.091 -20.295 12.899  1.00 83.04  ? 136 LEU A N   1 
ATOM 1160 C CA  . LEU A 1 142 ? 19.524 -20.515 12.785  1.00 73.71  ? 136 LEU A CA  1 
ATOM 1161 C C   . LEU A 1 142 ? 20.238 -20.132 14.074  1.00 84.79  ? 136 LEU A C   1 
ATOM 1162 O O   . LEU A 1 142 ? 19.813 -19.235 14.807  1.00 87.28  ? 136 LEU A O   1 
ATOM 1163 C CB  . LEU A 1 142 ? 20.098 -19.715 11.619  1.00 65.18  ? 136 LEU A CB  1 
ATOM 1164 C CG  . LEU A 1 142 ? 19.438 -19.996 10.269  1.00 79.11  ? 136 LEU A CG  1 
ATOM 1165 C CD1 . LEU A 1 142 ? 20.071 -19.155 9.173   1.00 71.84  ? 136 LEU A CD1 1 
ATOM 1166 C CD2 . LEU A 1 142 ? 19.506 -21.479 9.933   1.00 91.68  ? 136 LEU A CD2 1 
ATOM 1167 N N   . ARG A 1 143 ? 21.346 -20.818 14.337  1.00 72.57  ? 137 ARG A N   1 
ATOM 1168 C CA  . ARG A 1 143 ? 22.102 -20.614 15.563  1.00 78.83  ? 137 ARG A CA  1 
ATOM 1169 C C   . ARG A 1 143 ? 23.214 -19.585 15.412  1.00 84.71  ? 137 ARG A C   1 
ATOM 1170 O O   . ARG A 1 143 ? 23.830 -19.208 16.415  1.00 79.97  ? 137 ARG A O   1 
ATOM 1171 C CB  . ARG A 1 143 ? 22.679 -21.952 16.034  1.00 85.08  ? 137 ARG A CB  1 
ATOM 1172 C CG  . ARG A 1 143 ? 21.597 -22.989 16.292  1.00 88.39  ? 137 ARG A CG  1 
ATOM 1173 C CD  . ARG A 1 143 ? 22.167 -24.302 16.790  1.00 114.31 ? 137 ARG A CD  1 
ATOM 1174 N NE  . ARG A 1 143 ? 21.117 -25.288 17.020  1.00 125.96 ? 137 ARG A NE  1 
ATOM 1175 C CZ  . ARG A 1 143 ? 21.339 -26.530 17.430  1.00 133.95 ? 137 ARG A CZ  1 
ATOM 1176 N NH1 . ARG A 1 143 ? 22.565 -26.972 17.667  1.00 130.96 ? 137 ARG A NH1 1 
ATOM 1177 N NH2 . ARG A 1 143 ? 20.307 -27.352 17.601  1.00 124.85 ? 137 ARG A NH2 1 
ATOM 1178 N N   . ASN A 1 144 ? 23.478 -19.122 14.196  1.00 92.34  ? 138 ASN A N   1 
ATOM 1179 C CA  . ASN A 1 144 ? 24.487 -18.093 13.946  1.00 86.11  ? 138 ASN A CA  1 
ATOM 1180 C C   . ASN A 1 144 ? 23.817 -16.910 13.264  1.00 85.35  ? 138 ASN A C   1 
ATOM 1181 O O   . ASN A 1 144 ? 23.400 -17.028 12.095  1.00 98.67  ? 138 ASN A O   1 
ATOM 1182 C CB  . ASN A 1 144 ? 25.624 -18.638 13.081  1.00 98.46  ? 138 ASN A CB  1 
ATOM 1183 C CG  . ASN A 1 144 ? 26.731 -17.620 12.856  1.00 98.58  ? 138 ASN A CG  1 
ATOM 1184 O OD1 . ASN A 1 144 ? 26.696 -16.516 13.398  1.00 89.76  ? 138 ASN A OD1 1 
ATOM 1185 N ND2 . ASN A 1 144 ? 27.717 -17.988 12.044  1.00 86.82  ? 138 ASN A ND2 1 
ATOM 1186 N N   . PRO A 1 145 ? 23.682 -15.763 13.933  1.00 72.59  ? 139 PRO A N   1 
ATOM 1187 C CA  . PRO A 1 145 ? 23.053 -14.601 13.283  1.00 79.01  ? 139 PRO A CA  1 
ATOM 1188 C C   . PRO A 1 145 ? 23.785 -14.127 12.037  1.00 82.53  ? 139 PRO A C   1 
ATOM 1189 O O   . PRO A 1 145 ? 23.166 -13.491 11.172  1.00 72.50  ? 139 PRO A O   1 
ATOM 1190 C CB  . PRO A 1 145 ? 23.084 -13.534 14.383  1.00 61.80  ? 139 PRO A CB  1 
ATOM 1191 C CG  . PRO A 1 145 ? 23.071 -14.316 15.650  1.00 66.79  ? 139 PRO A CG  1 
ATOM 1192 C CD  . PRO A 1 145 ? 23.912 -15.531 15.369  1.00 72.52  ? 139 PRO A CD  1 
ATOM 1193 N N   . PHE A 1 146 ? 25.081 -14.425 11.913  1.00 85.70  ? 140 PHE A N   1 
ATOM 1194 C CA  . PHE A 1 146 ? 25.835 -13.969 10.750  1.00 66.65  ? 140 PHE A CA  1 
ATOM 1195 C C   . PHE A 1 146 ? 25.351 -14.651 9.476   1.00 63.77  ? 140 PHE A C   1 
ATOM 1196 O O   . PHE A 1 146 ? 25.275 -14.021 8.414   1.00 75.74  ? 140 PHE A O   1 
ATOM 1197 C CB  . PHE A 1 146 ? 27.329 -14.217 10.962  1.00 72.01  ? 140 PHE A CB  1 
ATOM 1198 C CG  . PHE A 1 146 ? 28.207 -13.476 9.995   1.00 63.05  ? 140 PHE A CG  1 
ATOM 1199 C CD1 . PHE A 1 146 ? 28.578 -12.165 10.244  1.00 56.18  ? 140 PHE A CD1 1 
ATOM 1200 C CD2 . PHE A 1 146 ? 28.660 -14.087 8.838   1.00 64.51  ? 140 PHE A CD2 1 
ATOM 1201 C CE1 . PHE A 1 146 ? 29.382 -11.477 9.356   1.00 68.60  ? 140 PHE A CE1 1 
ATOM 1202 C CE2 . PHE A 1 146 ? 29.466 -13.403 7.946   1.00 68.16  ? 140 PHE A CE2 1 
ATOM 1203 C CZ  . PHE A 1 146 ? 29.827 -12.097 8.206   1.00 70.67  ? 140 PHE A CZ  1 
ATOM 1204 N N   . ASP A 1 147 ? 25.016 -15.940 9.560   1.00 61.51  ? 141 ASP A N   1 
ATOM 1205 C CA  . ASP A 1 147 ? 24.471 -16.640 8.399   1.00 65.40  ? 141 ASP A CA  1 
ATOM 1206 C C   . ASP A 1 147 ? 23.131 -16.044 7.982   1.00 61.34  ? 141 ASP A C   1 
ATOM 1207 O O   . ASP A 1 147 ? 22.868 -15.833 6.790   1.00 64.67  ? 141 ASP A O   1 
ATOM 1208 C CB  . ASP A 1 147 ? 24.319 -18.132 8.706   1.00 72.73  ? 141 ASP A CB  1 
ATOM 1209 C CG  . ASP A 1 147 ? 25.655 -18.828 8.900   1.00 89.62  ? 141 ASP A CG  1 
ATOM 1210 O OD1 . ASP A 1 147 ? 26.703 -18.199 8.626   1.00 92.10  ? 141 ASP A OD1 1 
ATOM 1211 O OD2 . ASP A 1 147 ? 25.661 -20.001 9.333   1.00 93.25  ? 141 ASP A OD2 1 
ATOM 1212 N N   . ARG A 1 148 ? 22.265 -15.779 8.963   1.00 52.56  ? 142 ARG A N   1 
ATOM 1213 C CA  . ARG A 1 148 ? 20.981 -15.136 8.703   1.00 53.39  ? 142 ARG A CA  1 
ATOM 1214 C C   . ARG A 1 148 ? 21.173 -13.802 7.992   1.00 52.07  ? 142 ARG A C   1 
ATOM 1215 O O   . ARG A 1 148 ? 20.524 -13.524 6.975   1.00 65.73  ? 142 ARG A O   1 
ATOM 1216 C CB  . ARG A 1 148 ? 20.233 -14.947 10.028  1.00 68.76  ? 142 ARG A CB  1 
ATOM 1217 C CG  . ARG A 1 148 ? 18.934 -14.161 9.952   1.00 63.02  ? 142 ARG A CG  1 
ATOM 1218 C CD  . ARG A 1 148 ? 18.389 -13.881 11.355  1.00 79.14  ? 142 ARG A CD  1 
ATOM 1219 N NE  . ARG A 1 148 ? 18.216 -15.094 12.146  1.00 84.96  ? 142 ARG A NE  1 
ATOM 1220 C CZ  . ARG A 1 148 ? 18.828 -15.334 13.298  1.00 70.30  ? 142 ARG A CZ  1 
ATOM 1221 N NH1 . ARG A 1 148 ? 19.666 -14.461 13.833  1.00 63.46  ? 142 ARG A NH1 1 
ATOM 1222 N NH2 . ARG A 1 148 ? 18.592 -16.479 13.932  1.00 71.74  ? 142 ARG A NH2 1 
ATOM 1223 N N   . SER A 1 149 ? 22.068 -12.962 8.519   1.00 44.69  ? 143 SER A N   1 
ATOM 1224 C CA  . SER A 1 149 ? 22.309 -11.653 7.920   1.00 56.35  ? 143 SER A CA  1 
ATOM 1225 C C   . SER A 1 149 ? 22.881 -11.777 6.513   1.00 53.39  ? 143 SER A C   1 
ATOM 1226 O O   . SER A 1 149 ? 22.483 -11.032 5.611   1.00 55.02  ? 143 SER A O   1 
ATOM 1227 C CB  . SER A 1 149 ? 23.242 -10.834 8.808   1.00 54.09  ? 143 SER A CB  1 
ATOM 1228 O OG  . SER A 1 149 ? 24.476 -11.499 8.992   1.00 70.25  ? 143 SER A OG  1 
ATOM 1229 N N   . SER A 1 150 ? 23.817 -12.705 6.302   1.00 46.18  ? 144 SER A N   1 
ATOM 1230 C CA  . SER A 1 150 ? 24.392 -12.892 4.973   1.00 42.22  ? 144 SER A CA  1 
ATOM 1231 C C   . SER A 1 150 ? 23.323 -13.296 3.966   1.00 44.31  ? 144 SER A C   1 
ATOM 1232 O O   . SER A 1 150 ? 23.259 -12.753 2.854   1.00 43.21  ? 144 SER A O   1 
ATOM 1233 C CB  . SER A 1 150 ? 25.502 -13.943 5.025   1.00 32.86  ? 144 SER A CB  1 
ATOM 1234 O OG  . SER A 1 150 ? 26.578 -13.507 5.835   1.00 32.56  ? 144 SER A OG  1 
ATOM 1235 N N   . ILE A 1 151 ? 22.478 -14.260 4.341   1.00 39.65  ? 145 ILE A N   1 
ATOM 1236 C CA  . ILE A 1 151 ? 21.424 -14.712 3.437   1.00 38.87  ? 145 ILE A CA  1 
ATOM 1237 C C   . ILE A 1 151 ? 20.464 -13.569 3.129   1.00 49.34  ? 145 ILE A C   1 
ATOM 1238 O O   . ILE A 1 151 ? 20.088 -13.350 1.967   1.00 58.73  ? 145 ILE A O   1 
ATOM 1239 C CB  . ILE A 1 151 ? 20.697 -15.931 4.035   1.00 44.33  ? 145 ILE A CB  1 
ATOM 1240 C CG1 . ILE A 1 151 ? 21.664 -17.113 4.138   1.00 41.91  ? 145 ILE A CG1 1 
ATOM 1241 C CG2 . ILE A 1 151 ? 19.506 -16.316 3.171   1.00 42.76  ? 145 ILE A CG2 1 
ATOM 1242 C CD1 . ILE A 1 151 ? 21.179 -18.227 5.020   1.00 34.90  ? 145 ILE A CD1 1 
ATOM 1243 N N   . THR A 1 152 ? 20.073 -12.806 4.158   1.00 43.19  ? 146 THR A N   1 
ATOM 1244 C CA  . THR A 1 152 ? 19.153 -11.693 3.940   1.00 53.33  ? 146 THR A CA  1 
ATOM 1245 C C   . THR A 1 152 ? 19.762 -10.646 3.018   1.00 54.23  ? 146 THR A C   1 
ATOM 1246 O O   . THR A 1 152 ? 19.079 -10.111 2.142   1.00 63.68  ? 146 THR A O   1 
ATOM 1247 C CB  . THR A 1 152 ? 18.746 -11.061 5.273   1.00 55.28  ? 146 THR A CB  1 
ATOM 1248 O OG1 . THR A 1 152 ? 19.918 -10.749 6.036   1.00 74.04  ? 146 THR A OG1 1 
ATOM 1249 C CG2 . THR A 1 152 ? 17.872 -12.009 6.059   1.00 61.30  ? 146 THR A CG2 1 
ATOM 1250 N N   . PHE A 1 153 ? 21.052 -10.355 3.187   1.00 35.95  ? 147 PHE A N   1 
ATOM 1251 C CA  . PHE A 1 153 ? 21.705 -9.353  2.352   1.00 39.96  ? 147 PHE A CA  1 
ATOM 1252 C C   . PHE A 1 153 ? 21.775 -9.802  0.896   1.00 43.71  ? 147 PHE A C   1 
ATOM 1253 O O   . PHE A 1 153 ? 21.469 -9.029  -0.026  1.00 38.69  ? 147 PHE A O   1 
ATOM 1254 C CB  . PHE A 1 153 ? 23.106 -9.069  2.888   1.00 43.66  ? 147 PHE A CB  1 
ATOM 1255 C CG  . PHE A 1 153 ? 23.803 -7.950  2.178   1.00 48.34  ? 147 PHE A CG  1 
ATOM 1256 C CD1 . PHE A 1 153 ? 23.500 -6.631  2.473   1.00 46.66  ? 147 PHE A CD1 1 
ATOM 1257 C CD2 . PHE A 1 153 ? 24.750 -8.217  1.203   1.00 51.95  ? 147 PHE A CD2 1 
ATOM 1258 C CE1 . PHE A 1 153 ? 24.137 -5.601  1.818   1.00 46.07  ? 147 PHE A CE1 1 
ATOM 1259 C CE2 . PHE A 1 153 ? 25.385 -7.192  0.543   1.00 57.08  ? 147 PHE A CE2 1 
ATOM 1260 C CZ  . PHE A 1 153 ? 25.078 -5.881  0.852   1.00 64.19  ? 147 PHE A CZ  1 
ATOM 1261 N N   . CYS A 1 154 ? 22.194 -11.049 0.668   1.00 39.81  ? 148 CYS A N   1 
ATOM 1262 C CA  . CYS A 1 154 ? 22.301 -11.553 -0.698  1.00 39.60  ? 148 CYS A CA  1 
ATOM 1263 C C   . CYS A 1 154 ? 20.939 -11.565 -1.385  1.00 41.24  ? 148 CYS A C   1 
ATOM 1264 O O   . CYS A 1 154 ? 20.804 -11.128 -2.537  1.00 47.22  ? 148 CYS A O   1 
ATOM 1265 C CB  . CYS A 1 154 ? 22.919 -12.952 -0.693  1.00 40.46  ? 148 CYS A CB  1 
ATOM 1266 S SG  . CYS A 1 154 ? 24.675 -12.999 -0.294  1.00 38.29  ? 148 CYS A SG  1 
ATOM 1267 N N   . MET A 1 155 ? 19.908 -12.054 -0.690  1.00 33.75  ? 149 MET A N   1 
ATOM 1268 C CA  . MET A 1 155 ? 18.589 -12.092 -1.311  1.00 40.02  ? 149 MET A CA  1 
ATOM 1269 C C   . MET A 1 155 ? 18.009 -10.694 -1.465  1.00 34.06  ? 149 MET A C   1 
ATOM 1270 O O   . MET A 1 155 ? 17.191 -10.457 -2.360  1.00 32.59  ? 149 MET A O   1 
ATOM 1271 C CB  . MET A 1 155 ? 17.642 -12.971 -0.503  1.00 43.19  ? 149 MET A CB  1 
ATOM 1272 C CG  . MET A 1 155 ? 18.015 -14.437 -0.544  1.00 50.09  ? 149 MET A CG  1 
ATOM 1273 S SD  . MET A 1 155 ? 18.086 -15.095 -2.214  1.00 72.80  ? 149 MET A SD  1 
ATOM 1274 C CE  . MET A 1 155 ? 16.379 -14.978 -2.712  1.00 35.40  ? 149 MET A CE  1 
ATOM 1275 N N   . GLN A 1 156 ? 18.434 -9.757  -0.615  1.00 40.20  ? 150 GLN A N   1 
ATOM 1276 C CA  . GLN A 1 156 ? 18.052 -8.360  -0.779  1.00 49.10  ? 150 GLN A CA  1 
ATOM 1277 C C   . GLN A 1 156 ? 18.578 -7.794  -2.088  1.00 54.36  ? 150 GLN A C   1 
ATOM 1278 O O   . GLN A 1 156 ? 17.844 -7.128  -2.824  1.00 60.15  ? 150 GLN A O   1 
ATOM 1279 C CB  . GLN A 1 156 ? 18.564 -7.540  0.406   1.00 45.00  ? 150 GLN A CB  1 
ATOM 1280 C CG  . GLN A 1 156 ? 18.230 -6.067  0.327   1.00 56.60  ? 150 GLN A CG  1 
ATOM 1281 C CD  . GLN A 1 156 ? 16.761 -5.822  0.063   1.00 97.31  ? 150 GLN A CD  1 
ATOM 1282 O OE1 . GLN A 1 156 ? 15.893 -6.389  0.729   1.00 98.86  ? 150 GLN A OE1 1 
ATOM 1283 N NE2 . GLN A 1 156 ? 16.472 -4.975  -0.918  1.00 91.03  ? 150 GLN A NE2 1 
ATOM 1284 N N   . TYR A 1 157 ? 19.857 -8.030  -2.385  1.00 48.19  ? 151 TYR A N   1 
ATOM 1285 C CA  . TYR A 1 157 ? 20.387 -7.621  -3.687  1.00 39.66  ? 151 TYR A CA  1 
ATOM 1286 C C   . TYR A 1 157 ? 19.616 -8.288  -4.822  1.00 40.58  ? 151 TYR A C   1 
ATOM 1287 O O   . TYR A 1 157 ? 19.222 -7.633  -5.806  1.00 42.02  ? 151 TYR A O   1 
ATOM 1288 C CB  . TYR A 1 157 ? 21.875 -7.960  -3.787  1.00 30.48  ? 151 TYR A CB  1 
ATOM 1289 C CG  . TYR A 1 157 ? 22.471 -7.615  -5.133  1.00 33.02  ? 151 TYR A CG  1 
ATOM 1290 C CD1 . TYR A 1 157 ? 22.639 -6.293  -5.518  1.00 31.80  ? 151 TYR A CD1 1 
ATOM 1291 C CD2 . TYR A 1 157 ? 22.847 -8.609  -6.027  1.00 36.69  ? 151 TYR A CD2 1 
ATOM 1292 C CE1 . TYR A 1 157 ? 23.177 -5.971  -6.748  1.00 32.62  ? 151 TYR A CE1 1 
ATOM 1293 C CE2 . TYR A 1 157 ? 23.385 -8.295  -7.263  1.00 39.73  ? 151 TYR A CE2 1 
ATOM 1294 C CZ  . TYR A 1 157 ? 23.546 -6.975  -7.616  1.00 39.10  ? 151 TYR A CZ  1 
ATOM 1295 O OH  . TYR A 1 157 ? 24.078 -6.658  -8.843  1.00 41.86  ? 151 TYR A OH  1 
ATOM 1296 N N   . VAL A 1 158 ? 19.402 -9.603  -4.697  1.00 47.79  ? 152 VAL A N   1 
ATOM 1297 C CA  . VAL A 1 158 ? 18.737 -10.369 -5.749  1.00 43.75  ? 152 VAL A CA  1 
ATOM 1298 C C   . VAL A 1 158 ? 17.356 -9.794  -6.044  1.00 42.29  ? 152 VAL A C   1 
ATOM 1299 O O   . VAL A 1 158 ? 16.952 -9.676  -7.207  1.00 33.60  ? 152 VAL A O   1 
ATOM 1300 C CB  . VAL A 1 158 ? 18.661 -11.857 -5.354  1.00 29.45  ? 152 VAL A CB  1 
ATOM 1301 C CG1 . VAL A 1 158 ? 17.675 -12.603 -6.235  1.00 33.92  ? 152 VAL A CG1 1 
ATOM 1302 C CG2 . VAL A 1 158 ? 20.035 -12.501 -5.437  1.00 31.45  ? 152 VAL A CG2 1 
ATOM 1303 N N   . ASN A 1 159 ? 16.620 -9.409  -5.001  1.00 34.79  ? 153 ASN A N   1 
ATOM 1304 C CA  . ASN A 1 159 ? 15.282 -8.869  -5.204  1.00 36.46  ? 153 ASN A CA  1 
ATOM 1305 C C   . ASN A 1 159 ? 15.309 -7.399  -5.614  1.00 39.01  ? 153 ASN A C   1 
ATOM 1306 O O   . ASN A 1 159 ? 14.415 -6.946  -6.337  1.00 33.29  ? 153 ASN A O   1 
ATOM 1307 C CB  . ASN A 1 159 ? 14.454 -9.058  -3.934  1.00 25.67  ? 153 ASN A CB  1 
ATOM 1308 C CG  . ASN A 1 159 ? 14.217 -10.522 -3.610  1.00 35.34  ? 153 ASN A CG  1 
ATOM 1309 O OD1 . ASN A 1 159 ? 14.424 -11.399 -4.451  1.00 40.14  ? 153 ASN A OD1 1 
ATOM 1310 N ND2 . ASN A 1 159 ? 13.777 -10.793 -2.390  1.00 60.71  ? 153 ASN A ND2 1 
ATOM 1311 N N   . LYS A 1 160 ? 16.330 -6.648  -5.185  1.00 45.56  ? 154 LYS A N   1 
ATOM 1312 C CA  . LYS A 1 160 ? 16.402 -5.223  -5.495  1.00 42.85  ? 154 LYS A CA  1 
ATOM 1313 C C   . LYS A 1 160 ? 16.644 -4.981  -6.977  1.00 29.86  ? 154 LYS A C   1 
ATOM 1314 O O   . LYS A 1 160 ? 16.029 -4.085  -7.571  1.00 36.28  ? 154 LYS A O   1 
ATOM 1315 C CB  . LYS A 1 160 ? 17.503 -4.555  -4.671  1.00 46.15  ? 154 LYS A CB  1 
ATOM 1316 C CG  . LYS A 1 160 ? 17.635 -3.060  -4.927  1.00 32.70  ? 154 LYS A CG  1 
ATOM 1317 C CD  . LYS A 1 160 ? 18.461 -2.373  -3.855  1.00 60.44  ? 154 LYS A CD  1 
ATOM 1318 C CE  . LYS A 1 160 ? 18.459 -0.865  -4.046  1.00 63.53  ? 154 LYS A CE  1 
ATOM 1319 N NZ  . LYS A 1 160 ? 19.248 -0.157  -3.000  1.00 65.08  ? 154 LYS A NZ  1 
ATOM 1320 N N   . ILE A 1 161 ? 17.545 -5.751  -7.593  1.00 29.44  ? 155 ILE A N   1 
ATOM 1321 C CA  . ILE A 1 161 ? 17.780 -5.541  -9.024  1.00 34.79  ? 155 ILE A CA  1 
ATOM 1322 C C   . ILE A 1 161 ? 16.522 -5.871  -9.825  1.00 36.32  ? 155 ILE A C   1 
ATOM 1323 O O   . ILE A 1 161 ? 16.190 -5.193  -10.810 1.00 27.64  ? 155 ILE A O   1 
ATOM 1324 C CB  . ILE A 1 161 ? 19.008 -6.340  -9.500  1.00 26.88  ? 155 ILE A CB  1 
ATOM 1325 C CG1 . ILE A 1 161 ? 18.813 -7.837  -9.272  1.00 42.32  ? 155 ILE A CG1 1 
ATOM 1326 C CG2 . ILE A 1 161 ? 20.259 -5.838  -8.802  1.00 16.99  ? 155 ILE A CG2 1 
ATOM 1327 C CD1 . ILE A 1 161 ? 19.975 -8.669  -9.759  1.00 44.83  ? 155 ILE A CD1 1 
ATOM 1328 N N   . THR A 1 162 ? 15.779 -6.895  -9.393  1.00 43.41  ? 156 THR A N   1 
ATOM 1329 C CA  . THR A 1 162 ? 14.514 -7.235  -10.041 1.00 41.56  ? 156 THR A CA  1 
ATOM 1330 C C   . THR A 1 162 ? 13.496 -6.111  -9.883  1.00 37.61  ? 156 THR A C   1 
ATOM 1331 O O   . THR A 1 162 ? 12.807 -5.738  -10.840 1.00 40.39  ? 156 THR A O   1 
ATOM 1332 C CB  . THR A 1 162 ? 13.956 -8.538  -9.458  1.00 33.42  ? 156 THR A CB  1 
ATOM 1333 O OG1 . THR A 1 162 ? 14.859 -9.620  -9.717  1.00 31.92  ? 156 THR A OG1 1 
ATOM 1334 C CG2 . THR A 1 162 ? 12.592 -8.862  -10.057 1.00 32.29  ? 156 THR A CG2 1 
ATOM 1335 N N   . ALA A 1 163 ? 13.367 -5.580  -8.666  1.00 34.92  ? 157 ALA A N   1 
ATOM 1336 C CA  . ALA A 1 163 ? 12.440 -4.478  -8.434  1.00 29.16  ? 157 ALA A CA  1 
ATOM 1337 C C   . ALA A 1 163 ? 12.799 -3.271  -9.289  1.00 37.18  ? 157 ALA A C   1 
ATOM 1338 O O   . ALA A 1 163 ? 11.912 -2.568  -9.784  1.00 45.13  ? 157 ALA A O   1 
ATOM 1339 C CB  . ALA A 1 163 ? 12.429 -4.104  -6.950  1.00 40.95  ? 157 ALA A CB  1 
ATOM 1340 N N   . ILE A 1 164 ? 14.096 -3.018  -9.481  1.00 39.06  ? 158 ILE A N   1 
ATOM 1341 C CA  . ILE A 1 164 ? 14.506 -1.901  -10.329 1.00 35.45  ? 158 ILE A CA  1 
ATOM 1342 C C   . ILE A 1 164 ? 14.121 -2.154  -11.782 1.00 39.31  ? 158 ILE A C   1 
ATOM 1343 O O   . ILE A 1 164 ? 13.611 -1.257  -12.463 1.00 33.79  ? 158 ILE A O   1 
ATOM 1344 C CB  . ILE A 1 164 ? 16.014 -1.624  -10.188 1.00 30.29  ? 158 ILE A CB  1 
ATOM 1345 C CG1 . ILE A 1 164 ? 16.347 -1.170  -8.767  1.00 28.79  ? 158 ILE A CG1 1 
ATOM 1346 C CG2 . ILE A 1 164 ? 16.462 -0.577  -11.202 1.00 38.83  ? 158 ILE A CG2 1 
ATOM 1347 C CD1 . ILE A 1 164 ? 17.816 -1.268  -8.423  1.00 43.84  ? 158 ILE A CD1 1 
ATOM 1348 N N   . LEU A 1 165 ? 14.357 -3.368  -12.285 1.00 41.64  ? 159 LEU A N   1 
ATOM 1349 C CA  . LEU A 1 165 ? 14.023 -3.623  -13.684 1.00 41.77  ? 159 LEU A CA  1 
ATOM 1350 C C   . LEU A 1 165 ? 12.540 -3.863  -13.931 1.00 40.34  ? 159 LEU A C   1 
ATOM 1351 O O   . LEU A 1 165 ? 12.142 -3.986  -15.094 1.00 55.66  ? 159 LEU A O   1 
ATOM 1352 C CB  . LEU A 1 165 ? 14.823 -4.802  -14.228 1.00 40.47  ? 159 LEU A CB  1 
ATOM 1353 C CG  . LEU A 1 165 ? 16.317 -4.520  -14.292 1.00 48.69  ? 159 LEU A CG  1 
ATOM 1354 C CD1 . LEU A 1 165 ? 17.040 -5.758  -14.742 1.00 45.46  ? 159 LEU A CD1 1 
ATOM 1355 C CD2 . LEU A 1 165 ? 16.584 -3.360  -15.239 1.00 59.20  ? 159 LEU A CD2 1 
ATOM 1356 N N   . LEU A 1 166 ? 11.716 -3.938  -12.889 1.00 43.66  ? 160 LEU A N   1 
ATOM 1357 C CA  . LEU A 1 166 ? 10.272 -3.958  -13.081 1.00 38.16  ? 160 LEU A CA  1 
ATOM 1358 C C   . LEU A 1 166 ? 9.606  -2.625  -12.766 1.00 41.80  ? 160 LEU A C   1 
ATOM 1359 O O   . LEU A 1 166 ? 8.436  -2.436  -13.119 1.00 36.21  ? 160 LEU A O   1 
ATOM 1360 C CB  . LEU A 1 166 ? 9.632  -5.070  -12.243 1.00 42.33  ? 160 LEU A CB  1 
ATOM 1361 C CG  . LEU A 1 166 ? 10.024 -6.482  -12.670 1.00 35.30  ? 160 LEU A CG  1 
ATOM 1362 C CD1 . LEU A 1 166 ? 9.435  -7.499  -11.714 1.00 31.67  ? 160 LEU A CD1 1 
ATOM 1363 C CD2 . LEU A 1 166 ? 9.544  -6.737  -14.095 1.00 42.25  ? 160 LEU A CD2 1 
ATOM 1364 N N   . GLU A 1 167 ? 10.316 -1.701  -12.115 1.00 48.68  ? 161 GLU A N   1 
ATOM 1365 C CA  . GLU A 1 167 ? 9.809  -0.344  -11.963 1.00 39.34  ? 161 GLU A CA  1 
ATOM 1366 C C   . GLU A 1 167 ? 10.005 0.477   -13.227 1.00 50.94  ? 161 GLU A C   1 
ATOM 1367 O O   . GLU A 1 167 ? 9.462  1.583   -13.323 1.00 55.14  ? 161 GLU A O   1 
ATOM 1368 C CB  . GLU A 1 167 ? 10.479 0.343   -10.767 1.00 42.74  ? 161 GLU A CB  1 
ATOM 1369 C CG  . GLU A 1 167 ? 9.908  -0.090  -9.412  1.00 66.21  ? 161 GLU A CG  1 
ATOM 1370 C CD  . GLU A 1 167 ? 10.810 0.265   -8.239  1.00 71.24  ? 161 GLU A CD  1 
ATOM 1371 O OE1 . GLU A 1 167 ? 11.871 0.882   -8.468  1.00 68.42  ? 161 GLU A OE1 1 
ATOM 1372 O OE2 . GLU A 1 167 ? 10.461 -0.083  -7.089  1.00 67.99  ? 161 GLU A OE2 1 
ATOM 1373 N N   . GLU A 1 168 ? 10.764 -0.040  -14.190 1.00 49.23  ? 162 GLU A N   1 
ATOM 1374 C CA  . GLU A 1 168 ? 10.813 0.483   -15.545 1.00 47.82  ? 162 GLU A CA  1 
ATOM 1375 C C   . GLU A 1 168 ? 10.211 -0.536  -16.503 1.00 70.11  ? 162 GLU A C   1 
ATOM 1376 O O   . GLU A 1 168 ? 10.139 -1.733  -16.212 1.00 80.78  ? 162 GLU A O   1 
ATOM 1377 C CB  . GLU A 1 168 ? 12.245 0.810   -15.978 1.00 51.13  ? 162 GLU A CB  1 
ATOM 1378 C CG  . GLU A 1 168 ? 13.084 -0.415  -16.281 1.00 62.93  ? 162 GLU A CG  1 
ATOM 1379 C CD  . GLU A 1 168 ? 14.491 -0.052  -16.677 1.00 62.99  ? 162 GLU A CD  1 
ATOM 1380 O OE1 . GLU A 1 168 ? 14.843 1.135   -16.542 1.00 45.22  ? 162 GLU A OE1 1 
ATOM 1381 O OE2 . GLU A 1 168 ? 15.253 -0.948  -17.095 1.00 66.96  ? 162 GLU A OE2 1 
ATOM 1382 N N   . GLY A 1 169 ? 9.763  -0.045  -17.652 1.00 72.06  ? 163 GLY A N   1 
ATOM 1383 C CA  . GLY A 1 169 ? 9.214  -0.889  -18.690 1.00 70.02  ? 163 GLY A CA  1 
ATOM 1384 C C   . GLY A 1 169 ? 10.199 -1.296  -19.761 1.00 62.66  ? 163 GLY A C   1 
ATOM 1385 O O   . GLY A 1 169 ? 9.795  -1.923  -20.745 1.00 79.68  ? 163 GLY A O   1 
ATOM 1386 N N   . ASN A 1 170 ? 11.481 -0.967  -19.598 1.00 64.86  ? 164 ASN A N   1 
ATOM 1387 C CA  . ASN A 1 170 ? 12.454 -1.209  -20.655 1.00 62.53  ? 164 ASN A CA  1 
ATOM 1388 C C   . ASN A 1 170 ? 12.750 -2.694  -20.809 1.00 64.72  ? 164 ASN A C   1 
ATOM 1389 O O   . ASN A 1 170 ? 12.721 -3.230  -21.920 1.00 36.33  ? 164 ASN A O   1 
ATOM 1390 C CB  . ASN A 1 170 ? 13.735 -0.429  -20.368 1.00 62.87  ? 164 ASN A CB  1 
ATOM 1391 C CG  . ASN A 1 170 ? 13.499 1.063   -20.284 1.00 81.59  ? 164 ASN A CG  1 
ATOM 1392 O OD1 . ASN A 1 170 ? 12.510 1.577   -20.810 1.00 93.62  ? 164 ASN A OD1 1 
ATOM 1393 N ND2 . ASN A 1 170 ? 14.406 1.770   -19.620 1.00 89.11  ? 164 ASN A ND2 1 
ATOM 1394 N N   . THR A 1 171 ? 13.044 -3.377  -19.706 1.00 74.46  ? 165 THR A N   1 
ATOM 1395 C CA  . THR A 1 171 ? 13.375 -4.794  -19.813 1.00 65.94  ? 165 THR A CA  1 
ATOM 1396 C C   . THR A 1 171 ? 12.108 -5.634  -19.737 1.00 64.44  ? 165 THR A C   1 
ATOM 1397 O O   . THR A 1 171 ? 11.268 -5.399  -18.857 1.00 66.93  ? 165 THR A O   1 
ATOM 1398 C CB  . THR A 1 171 ? 14.339 -5.219  -18.715 1.00 63.04  ? 165 THR A CB  1 
ATOM 1399 O OG1 . THR A 1 171 ? 15.432 -4.292  -18.647 1.00 92.59  ? 165 THR A OG1 1 
ATOM 1400 C CG2 . THR A 1 171 ? 14.871 -6.613  -18.993 1.00 32.50  ? 165 THR A CG2 1 
ATOM 1401 N N   . PRO A 1 172 ? 11.928 -6.600  -20.630 1.00 55.55  ? 166 PRO A N   1 
ATOM 1402 C CA  . PRO A 1 172 ? 10.739 -7.449  -20.559 1.00 46.77  ? 166 PRO A CA  1 
ATOM 1403 C C   . PRO A 1 172 ? 10.713 -8.232  -19.256 1.00 61.04  ? 166 PRO A C   1 
ATOM 1404 O O   . PRO A 1 172 ? 11.748 -8.596  -18.703 1.00 60.35  ? 166 PRO A O   1 
ATOM 1405 C CB  . PRO A 1 172 ? 10.889 -8.374  -21.771 1.00 35.10  ? 166 PRO A CB  1 
ATOM 1406 C CG  . PRO A 1 172 ? 11.704 -7.564  -22.751 1.00 45.20  ? 166 PRO A CG  1 
ATOM 1407 C CD  . PRO A 1 172 ? 12.666 -6.786  -21.889 1.00 48.32  ? 166 PRO A CD  1 
ATOM 1408 N N   . HIS A 1 173 ? 9.510  -8.444  -18.747 1.00 69.33  ? 167 HIS A N   1 
ATOM 1409 C CA  . HIS A 1 173 ? 9.197  -9.316  -17.620 1.00 72.78  ? 167 HIS A CA  1 
ATOM 1410 C C   . HIS A 1 173 ? 9.932  -10.664 -17.557 1.00 58.98  ? 167 HIS A C   1 
ATOM 1411 O O   . HIS A 1 173 ? 10.673 -10.942 -16.599 1.00 68.22  ? 167 HIS A O   1 
ATOM 1412 C CB  . HIS A 1 173 ? 7.685  -9.514  -17.664 1.00 70.71  ? 167 HIS A CB  1 
ATOM 1413 C CG  . HIS A 1 173 ? 7.192  -9.990  -18.994 1.00 91.13  ? 167 HIS A CG  1 
ATOM 1414 N ND1 . HIS A 1 173 ? 6.948  -9.137  -20.043 1.00 79.46  ? 167 HIS A ND1 1 
ATOM 1415 C CD2 . HIS A 1 173 ? 6.942  -11.239 -19.456 1.00 100.99 ? 167 HIS A CD2 1 
ATOM 1416 C CE1 . HIS A 1 173 ? 6.519  -9.830  -21.085 1.00 84.10  ? 167 HIS A CE1 1 
ATOM 1417 N NE2 . HIS A 1 173 ? 6.507  -11.106 -20.753 1.00 102.81 ? 167 HIS A NE2 1 
ATOM 1418 N N   . HIS A 1 174 ? 9.696  -11.521 -18.551 1.00 52.19  ? 168 HIS A N   1 
ATOM 1419 C CA  . HIS A 1 174 ? 10.108 -12.922 -18.478 1.00 52.09  ? 168 HIS A CA  1 
ATOM 1420 C C   . HIS A 1 174 ? 11.618 -13.087 -18.463 1.00 55.36  ? 168 HIS A C   1 
ATOM 1421 O O   . HIS A 1 174 ? 12.110 -14.100 -17.953 1.00 62.98  ? 168 HIS A O   1 
ATOM 1422 C CB  . HIS A 1 174 ? 9.510  -13.697 -19.654 1.00 55.41  ? 168 HIS A CB  1 
ATOM 1423 C CG  . HIS A 1 174 ? 9.842  -13.103 -20.984 1.00 48.13  ? 168 HIS A CG  1 
ATOM 1424 N ND1 . HIS A 1 174 ? 9.112  -12.073 -21.540 1.00 72.79  ? 168 HIS A ND1 1 
ATOM 1425 C CD2 . HIS A 1 174 ? 10.787 -13.424 -21.898 1.00 38.91  ? 168 HIS A CD2 1 
ATOM 1426 C CE1 . HIS A 1 174 ? 9.617  -11.758 -22.717 1.00 85.37  ? 168 HIS A CE1 1 
ATOM 1427 N NE2 . HIS A 1 174 ? 10.631 -12.570 -22.962 1.00 75.44  ? 168 HIS A NE2 1 
ATOM 1428 N N   . VAL A 1 175 ? 12.358 -12.122 -19.005 1.00 49.71  ? 169 VAL A N   1 
ATOM 1429 C CA  . VAL A 1 175 ? 13.812 -12.178 -18.944 1.00 47.01  ? 169 VAL A CA  1 
ATOM 1430 C C   . VAL A 1 175 ? 14.336 -11.609 -17.628 1.00 53.13  ? 169 VAL A C   1 
ATOM 1431 O O   . VAL A 1 175 ? 15.398 -12.029 -17.161 1.00 62.33  ? 169 VAL A O   1 
ATOM 1432 C CB  . VAL A 1 175 ? 14.439 -11.460 -20.151 1.00 38.99  ? 169 VAL A CB  1 
ATOM 1433 C CG1 . VAL A 1 175 ? 14.030 -12.162 -21.434 1.00 49.79  ? 169 VAL A CG1 1 
ATOM 1434 C CG2 . VAL A 1 175 ? 14.042 -10.004 -20.191 1.00 39.66  ? 169 VAL A CG2 1 
ATOM 1435 N N   . VAL A 1 176 ? 13.602 -10.683 -17.001 1.00 55.11  ? 170 VAL A N   1 
ATOM 1436 C CA  . VAL A 1 176 ? 13.945 -10.277 -15.638 1.00 43.48  ? 170 VAL A CA  1 
ATOM 1437 C C   . VAL A 1 176 ? 13.830 -11.470 -14.697 1.00 34.23  ? 170 VAL A C   1 
ATOM 1438 O O   . VAL A 1 176 ? 14.646 -11.641 -13.779 1.00 44.90  ? 170 VAL A O   1 
ATOM 1439 C CB  . VAL A 1 176 ? 13.061 -9.101  -15.172 1.00 37.08  ? 170 VAL A CB  1 
ATOM 1440 C CG1 . VAL A 1 176 ? 13.298 -8.796  -13.695 1.00 27.66  ? 170 VAL A CG1 1 
ATOM 1441 C CG2 . VAL A 1 176 ? 13.325 -7.864  -16.007 1.00 50.70  ? 170 VAL A CG2 1 
ATOM 1442 N N   . TYR A 1 177 ? 12.821 -12.318 -14.918 1.00 31.47  ? 171 TYR A N   1 
ATOM 1443 C CA  . TYR A 1 177 ? 12.700 -13.544 -14.127 1.00 41.41  ? 171 TYR A CA  1 
ATOM 1444 C C   . TYR A 1 177 ? 13.943 -14.422 -14.268 1.00 40.70  ? 171 TYR A C   1 
ATOM 1445 O O   . TYR A 1 177 ? 14.511 -14.888 -13.268 1.00 38.61  ? 171 TYR A O   1 
ATOM 1446 C CB  . TYR A 1 177 ? 11.439 -14.305 -14.544 1.00 43.63  ? 171 TYR A CB  1 
ATOM 1447 C CG  . TYR A 1 177 ? 11.150 -15.557 -13.738 1.00 39.91  ? 171 TYR A CG  1 
ATOM 1448 C CD1 . TYR A 1 177 ? 10.790 -15.478 -12.396 1.00 41.37  ? 171 TYR A CD1 1 
ATOM 1449 C CD2 . TYR A 1 177 ? 11.193 -16.813 -14.329 1.00 57.54  ? 171 TYR A CD2 1 
ATOM 1450 C CE1 . TYR A 1 177 ? 10.515 -16.619 -11.658 1.00 48.40  ? 171 TYR A CE1 1 
ATOM 1451 C CE2 . TYR A 1 177 ? 10.911 -17.957 -13.603 1.00 61.85  ? 171 TYR A CE2 1 
ATOM 1452 C CZ  . TYR A 1 177 ? 10.577 -17.854 -12.267 1.00 62.99  ? 171 TYR A CZ  1 
ATOM 1453 O OH  . TYR A 1 177 ? 10.300 -18.989 -11.539 1.00 55.04  ? 171 TYR A OH  1 
ATOM 1454 N N   . ASN A 1 178 ? 14.382 -14.653 -15.508 1.00 42.60  ? 172 ASN A N   1 
ATOM 1455 C CA  . ASN A 1 178 ? 15.579 -15.453 -15.747 1.00 36.34  ? 172 ASN A CA  1 
ATOM 1456 C C   . ASN A 1 178 ? 16.809 -14.807 -15.124 1.00 36.52  ? 172 ASN A C   1 
ATOM 1457 O O   . ASN A 1 178 ? 17.678 -15.505 -14.596 1.00 40.22  ? 172 ASN A O   1 
ATOM 1458 C CB  . ASN A 1 178 ? 15.782 -15.639 -17.249 1.00 46.54  ? 172 ASN A CB  1 
ATOM 1459 C CG  . ASN A 1 178 ? 14.676 -16.442 -17.883 1.00 57.56  ? 172 ASN A CG  1 
ATOM 1460 O OD1 . ASN A 1 178 ? 13.834 -17.010 -17.187 1.00 56.76  ? 172 ASN A OD1 1 
ATOM 1461 N ND2 . ASN A 1 178 ? 14.652 -16.476 -19.210 1.00 55.69  ? 172 ASN A ND2 1 
ATOM 1462 N N   . LEU A 1 179 ? 16.905 -13.479 -15.191 1.00 38.50  ? 173 LEU A N   1 
ATOM 1463 C CA  . LEU A 1 179 ? 18.031 -12.773 -14.587 1.00 34.87  ? 173 LEU A CA  1 
ATOM 1464 C C   . LEU A 1 179 ? 18.088 -13.010 -13.084 1.00 33.81  ? 173 LEU A C   1 
ATOM 1465 O O   . LEU A 1 179 ? 19.157 -13.299 -12.527 1.00 42.17  ? 173 LEU A O   1 
ATOM 1466 C CB  . LEU A 1 179 ? 17.920 -11.282 -14.889 1.00 27.42  ? 173 LEU A CB  1 
ATOM 1467 C CG  . LEU A 1 179 ? 18.831 -10.367 -14.083 1.00 29.20  ? 173 LEU A CG  1 
ATOM 1468 C CD1 . LEU A 1 179 ? 20.286 -10.604 -14.425 1.00 41.12  ? 173 LEU A CD1 1 
ATOM 1469 C CD2 . LEU A 1 179 ? 18.449 -8.936  -14.344 1.00 33.20  ? 173 LEU A CD2 1 
ATOM 1470 N N   . ARG A 1 180 ? 16.948 -12.857 -12.406 1.00 29.33  ? 174 ARG A N   1 
ATOM 1471 C CA  . ARG A 1 180 ? 16.898 -13.110 -10.969 1.00 38.31  ? 174 ARG A CA  1 
ATOM 1472 C C   . ARG A 1 180 ? 17.333 -14.537 -10.653 1.00 41.98  ? 174 ARG A C   1 
ATOM 1473 O O   . ARG A 1 180 ? 18.134 -14.771 -9.735  1.00 36.72  ? 174 ARG A O   1 
ATOM 1474 C CB  . ARG A 1 180 ? 15.488 -12.863 -10.436 1.00 39.15  ? 174 ARG A CB  1 
ATOM 1475 C CG  . ARG A 1 180 ? 15.406 -12.928 -8.928  1.00 47.00  ? 174 ARG A CG  1 
ATOM 1476 C CD  . ARG A 1 180 ? 14.006 -12.637 -8.436  1.00 43.53  ? 174 ARG A CD  1 
ATOM 1477 N NE  . ARG A 1 180 ? 13.064 -13.624 -8.946  1.00 69.29  ? 174 ARG A NE  1 
ATOM 1478 C CZ  . ARG A 1 180 ? 12.834 -14.795 -8.368  1.00 89.10  ? 174 ARG A CZ  1 
ATOM 1479 N NH1 . ARG A 1 180 ? 13.457 -15.145 -7.251  1.00 71.82  ? 174 ARG A NH1 1 
ATOM 1480 N NH2 . ARG A 1 180 ? 11.969 -15.638 -8.929  1.00 94.26  ? 174 ARG A NH2 1 
ATOM 1481 N N   . ARG A 1 181 ? 16.789 -15.509 -11.393 1.00 37.47  ? 175 ARG A N   1 
ATOM 1482 C CA  . ARG A 1 181 ? 17.175 -16.901 -11.172 1.00 29.68  ? 175 ARG A CA  1 
ATOM 1483 C C   . ARG A 1 181 ? 18.670 -17.099 -11.383 1.00 35.41  ? 175 ARG A C   1 
ATOM 1484 O O   . ARG A 1 181 ? 19.319 -17.822 -10.623 1.00 38.93  ? 175 ARG A O   1 
ATOM 1485 C CB  . ARG A 1 181 ? 16.377 -17.828 -12.090 1.00 35.93  ? 175 ARG A CB  1 
ATOM 1486 C CG  . ARG A 1 181 ? 14.934 -17.992 -11.669 1.00 55.81  ? 175 ARG A CG  1 
ATOM 1487 C CD  . ARG A 1 181 ? 14.121 -18.640 -12.759 1.00 66.97  ? 175 ARG A CD  1 
ATOM 1488 N NE  . ARG A 1 181 ? 14.550 -20.007 -13.027 1.00 50.49  ? 175 ARG A NE  1 
ATOM 1489 C CZ  . ARG A 1 181 ? 14.236 -20.685 -14.123 1.00 58.54  ? 175 ARG A CZ  1 
ATOM 1490 N NH1 . ARG A 1 181 ? 13.522 -20.140 -15.095 1.00 49.46  ? 175 ARG A NH1 1 
ATOM 1491 N NH2 . ARG A 1 181 ? 14.641 -21.944 -14.244 1.00 60.09  ? 175 ARG A NH2 1 
ATOM 1492 N N   . ARG A 1 182 ? 19.231 -16.457 -12.407 1.00 46.58  ? 176 ARG A N   1 
ATOM 1493 C CA  . ARG A 1 182 ? 20.659 -16.561 -12.686 1.00 37.85  ? 176 ARG A CA  1 
ATOM 1494 C C   . ARG A 1 182 ? 21.485 -16.052 -11.513 1.00 39.24  ? 176 ARG A C   1 
ATOM 1495 O O   . ARG A 1 182 ? 22.425 -16.719 -11.063 1.00 47.55  ? 176 ARG A O   1 
ATOM 1496 C CB  . ARG A 1 182 ? 20.961 -15.789 -13.971 1.00 28.96  ? 176 ARG A CB  1 
ATOM 1497 C CG  . ARG A 1 182 ? 22.390 -15.813 -14.458 1.00 44.42  ? 176 ARG A CG  1 
ATOM 1498 C CD  . ARG A 1 182 ? 22.433 -15.235 -15.868 1.00 61.17  ? 176 ARG A CD  1 
ATOM 1499 N NE  . ARG A 1 182 ? 22.243 -13.790 -15.902 1.00 57.44  ? 176 ARG A NE  1 
ATOM 1500 C CZ  . ARG A 1 182 ? 22.371 -13.048 -16.995 1.00 38.57  ? 176 ARG A CZ  1 
ATOM 1501 N NH1 . ARG A 1 182 ? 22.693 -13.583 -18.161 1.00 49.53  ? 176 ARG A NH1 1 
ATOM 1502 N NH2 . ARG A 1 182 ? 22.163 -11.737 -16.921 1.00 25.94  ? 176 ARG A NH2 1 
ATOM 1503 N N   . THR A 1 183 ? 21.125 -14.882 -10.984 1.00 37.51  ? 177 THR A N   1 
ATOM 1504 C CA  . THR A 1 183 ? 21.874 -14.307 -9.869  1.00 34.87  ? 177 THR A CA  1 
ATOM 1505 C C   . THR A 1 183 ? 21.817 -15.209 -8.634  1.00 29.34  ? 177 THR A C   1 
ATOM 1506 O O   . THR A 1 183 ? 22.857 -15.554 -8.045  1.00 30.64  ? 177 THR A O   1 
ATOM 1507 C CB  . THR A 1 183 ? 21.334 -12.912 -9.549  1.00 28.47  ? 177 THR A CB  1 
ATOM 1508 O OG1 . THR A 1 183 ? 21.336 -12.114 -10.739 1.00 21.96  ? 177 THR A OG1 1 
ATOM 1509 C CG2 . THR A 1 183 ? 22.193 -12.231 -8.500  1.00 35.73  ? 177 THR A CG2 1 
ATOM 1510 N N   . SER A 1 184 ? 20.605 -15.608 -8.229  1.00 30.25  ? 178 SER A N   1 
ATOM 1511 C CA  . SER A 1 184 ? 20.485 -16.424 -7.021  1.00 33.25  ? 178 SER A CA  1 
ATOM 1512 C C   . SER A 1 184 ? 21.140 -17.787 -7.200  1.00 35.09  ? 178 SER A C   1 
ATOM 1513 O O   . SER A 1 184 ? 21.710 -18.332 -6.245  1.00 45.13  ? 178 SER A O   1 
ATOM 1514 C CB  . SER A 1 184 ? 19.018 -16.591 -6.622  1.00 30.77  ? 178 SER A CB  1 
ATOM 1515 O OG  . SER A 1 184 ? 18.261 -17.174 -7.664  1.00 54.16  ? 178 SER A OG  1 
ATOM 1516 N N   . ASN A 1 185 ? 21.089 -18.346 -8.411  1.00 29.63  ? 179 ASN A N   1 
ATOM 1517 C CA  . ASN A 1 185 ? 21.774 -19.604 -8.668  1.00 33.81  ? 179 ASN A CA  1 
ATOM 1518 C C   . ASN A 1 185 ? 23.285 -19.438 -8.566  1.00 36.79  ? 179 ASN A C   1 
ATOM 1519 O O   . ASN A 1 185 ? 23.972 -20.330 -8.061  1.00 32.67  ? 179 ASN A O   1 
ATOM 1520 C CB  . ASN A 1 185 ? 21.375 -20.141 -10.041 1.00 39.57  ? 179 ASN A CB  1 
ATOM 1521 C CG  . ASN A 1 185 ? 20.003 -20.785 -10.033 1.00 45.76  ? 179 ASN A CG  1 
ATOM 1522 O OD1 . ASN A 1 185 ? 19.483 -21.144 -8.976  1.00 43.15  ? 179 ASN A OD1 1 
ATOM 1523 N ND2 . ASN A 1 185 ? 19.401 -20.915 -11.208 1.00 53.00  ? 179 ASN A ND2 1 
ATOM 1524 N N   . ALA A 1 186 ? 23.819 -18.304 -9.025  1.00 41.28  ? 180 ALA A N   1 
ATOM 1525 C CA  . ALA A 1 186 ? 25.250 -18.052 -8.874  1.00 28.31  ? 180 ALA A CA  1 
ATOM 1526 C C   . ALA A 1 186 ? 25.643 -18.039 -7.401  1.00 21.50  ? 180 ALA A C   1 
ATOM 1527 O O   . ALA A 1 186 ? 26.638 -18.662 -7.002  1.00 23.97  ? 180 ALA A O   1 
ATOM 1528 C CB  . ALA A 1 186 ? 25.627 -16.732 -9.550  1.00 18.09  ? 180 ALA A CB  1 
ATOM 1529 N N   . ILE A 1 187 ? 24.854 -17.350 -6.571  1.00 30.28  ? 181 ILE A N   1 
ATOM 1530 C CA  . ILE A 1 187 ? 25.170 -17.295 -5.140  1.00 36.36  ? 181 ILE A CA  1 
ATOM 1531 C C   . ILE A 1 187 ? 25.095 -18.688 -4.509  1.00 30.47  ? 181 ILE A C   1 
ATOM 1532 O O   . ILE A 1 187 ? 25.971 -19.089 -3.722  1.00 24.35  ? 181 ILE A O   1 
ATOM 1533 C CB  . ILE A 1 187 ? 24.246 -16.295 -4.418  1.00 23.12  ? 181 ILE A CB  1 
ATOM 1534 C CG1 . ILE A 1 187 ? 24.444 -14.886 -4.977  1.00 29.62  ? 181 ILE A CG1 1 
ATOM 1535 C CG2 . ILE A 1 187 ? 24.509 -16.307 -2.920  1.00 10.52  ? 181 ILE A CG2 1 
ATOM 1536 C CD1 . ILE A 1 187 ? 23.347 -13.919 -4.605  1.00 23.45  ? 181 ILE A CD1 1 
ATOM 1537 N N   . SER A 1 188 ? 24.049 -19.449 -4.846  1.00 33.06  ? 182 SER A N   1 
ATOM 1538 C CA  . SER A 1 188 ? 23.887 -20.782 -4.269  1.00 33.72  ? 182 SER A CA  1 
ATOM 1539 C C   . SER A 1 188 ? 25.000 -21.719 -4.715  1.00 30.11  ? 182 SER A C   1 
ATOM 1540 O O   . SER A 1 188 ? 25.463 -22.557 -3.933  1.00 35.59  ? 182 SER A O   1 
ATOM 1541 C CB  . SER A 1 188 ? 22.524 -21.361 -4.644  1.00 40.43  ? 182 SER A CB  1 
ATOM 1542 O OG  . SER A 1 188 ? 22.501 -21.763 -6.000  1.00 48.88  ? 182 SER A OG  1 
ATOM 1543 N N   . ILE A 1 189 ? 25.451 -21.586 -5.964  1.00 25.05  ? 183 ILE A N   1 
ATOM 1544 C CA  . ILE A 1 189 ? 26.548 -22.410 -6.452  1.00 26.64  ? 183 ILE A CA  1 
ATOM 1545 C C   . ILE A 1 189 ? 27.854 -22.025 -5.771  1.00 26.80  ? 183 ILE A C   1 
ATOM 1546 O O   . ILE A 1 189 ? 28.712 -22.881 -5.533  1.00 30.20  ? 183 ILE A O   1 
ATOM 1547 C CB  . ILE A 1 189 ? 26.643 -22.307 -7.987  1.00 32.15  ? 183 ILE A CB  1 
ATOM 1548 C CG1 . ILE A 1 189 ? 25.487 -23.068 -8.637  1.00 41.27  ? 183 ILE A CG1 1 
ATOM 1549 C CG2 . ILE A 1 189 ? 27.977 -22.844 -8.497  1.00 32.18  ? 183 ILE A CG2 1 
ATOM 1550 C CD1 . ILE A 1 189 ? 25.294 -22.754 -10.100 1.00 36.26  ? 183 ILE A CD1 1 
ATOM 1551 N N   . ALA A 1 190 ? 28.031 -20.746 -5.439  1.00 21.26  ? 184 ALA A N   1 
ATOM 1552 C CA  . ALA A 1 190 ? 29.198 -20.354 -4.651  1.00 36.50  ? 184 ALA A CA  1 
ATOM 1553 C C   . ALA A 1 190 ? 29.192 -21.030 -3.284  1.00 47.44  ? 184 ALA A C   1 
ATOM 1554 O O   . ALA A 1 190 ? 30.219 -21.554 -2.829  1.00 47.28  ? 184 ALA A O   1 
ATOM 1555 C CB  . ALA A 1 190 ? 29.244 -18.837 -4.497  1.00 33.20  ? 184 ALA A CB  1 
ATOM 1556 N N   . PHE A 1 191 ? 28.041 -21.006 -2.601  1.00 42.06  ? 185 PHE A N   1 
ATOM 1557 C CA  . PHE A 1 191 ? 27.934 -21.726 -1.331  1.00 36.53  ? 185 PHE A CA  1 
ATOM 1558 C C   . PHE A 1 191 ? 28.222 -23.213 -1.507  1.00 36.19  ? 185 PHE A C   1 
ATOM 1559 O O   . PHE A 1 191 ? 28.912 -23.824 -0.683  1.00 42.00  ? 185 PHE A O   1 
ATOM 1560 C CB  . PHE A 1 191 ? 26.553 -21.528 -0.703  1.00 34.86  ? 185 PHE A CB  1 
ATOM 1561 C CG  . PHE A 1 191 ? 26.329 -20.154 -0.154  1.00 38.81  ? 185 PHE A CG  1 
ATOM 1562 C CD1 . PHE A 1 191 ? 27.297 -19.543 0.627   1.00 34.92  ? 185 PHE A CD1 1 
ATOM 1563 C CD2 . PHE A 1 191 ? 25.147 -19.477 -0.401  1.00 44.64  ? 185 PHE A CD2 1 
ATOM 1564 C CE1 . PHE A 1 191 ? 27.090 -18.277 1.141   1.00 34.27  ? 185 PHE A CE1 1 
ATOM 1565 C CE2 . PHE A 1 191 ? 24.937 -18.213 0.111   1.00 32.19  ? 185 PHE A CE2 1 
ATOM 1566 C CZ  . PHE A 1 191 ? 25.909 -17.614 0.882   1.00 33.68  ? 185 PHE A CZ  1 
ATOM 1567 N N   . GLN A 1 192 ? 27.704 -23.812 -2.581  1.00 37.15  ? 186 GLN A N   1 
ATOM 1568 C CA  . GLN A 1 192 ? 27.943 -25.232 -2.828  1.00 44.82  ? 186 GLN A CA  1 
ATOM 1569 C C   . GLN A 1 192 ? 29.422 -25.518 -3.062  1.00 40.02  ? 186 GLN A C   1 
ATOM 1570 O O   . GLN A 1 192 ? 29.941 -26.539 -2.606  1.00 43.45  ? 186 GLN A O   1 
ATOM 1571 C CB  . GLN A 1 192 ? 27.106 -25.709 -4.016  1.00 40.84  ? 186 GLN A CB  1 
ATOM 1572 C CG  . GLN A 1 192 ? 25.618 -25.770 -3.718  1.00 40.62  ? 186 GLN A CG  1 
ATOM 1573 C CD  . GLN A 1 192 ? 24.791 -26.156 -4.926  1.00 39.09  ? 186 GLN A CD  1 
ATOM 1574 O OE1 . GLN A 1 192 ? 24.477 -27.329 -5.130  1.00 59.82  ? 186 GLN A OE1 1 
ATOM 1575 N NE2 . GLN A 1 192 ? 24.448 -25.171 -5.745  1.00 44.64  ? 186 GLN A NE2 1 
ATOM 1576 N N   . ALA A 1 193 ? 30.122 -24.622 -3.758  1.00 41.90  ? 187 ALA A N   1 
ATOM 1577 C CA  . ALA A 1 193 ? 31.549 -24.816 -4.001  1.00 57.76  ? 187 ALA A CA  1 
ATOM 1578 C C   . ALA A 1 193 ? 32.357 -24.685 -2.713  1.00 54.21  ? 187 ALA A C   1 
ATOM 1579 O O   . ALA A 1 193 ? 33.271 -25.483 -2.461  1.00 52.12  ? 187 ALA A O   1 
ATOM 1580 C CB  . ALA A 1 193 ? 32.045 -23.817 -5.047  1.00 63.92  ? 187 ALA A CB  1 
ATOM 1581 N N   . VAL A 1 194 ? 32.041 -23.688 -1.881  1.00 62.36  ? 188 VAL A N   1 
ATOM 1582 C CA  . VAL A 1 194 ? 32.776 -23.565 -0.624  1.00 56.02  ? 188 VAL A CA  1 
ATOM 1583 C C   . VAL A 1 194 ? 32.447 -24.722 0.316   1.00 52.28  ? 188 VAL A C   1 
ATOM 1584 O O   . VAL A 1 194 ? 33.264 -25.070 1.177   1.00 60.03  ? 188 VAL A O   1 
ATOM 1585 C CB  . VAL A 1 194 ? 32.523 -22.203 0.060   1.00 55.70  ? 188 VAL A CB  1 
ATOM 1586 C CG1 . VAL A 1 194 ? 31.125 -22.124 0.630   1.00 72.09  ? 188 VAL A CG1 1 
ATOM 1587 C CG2 . VAL A 1 194 ? 33.562 -21.950 1.154   1.00 40.53  ? 188 VAL A CG2 1 
ATOM 1588 N N   . LEU A 1 195 ? 31.269 -25.337 0.170   1.00 56.19  ? 189 LEU A N   1 
ATOM 1589 C CA  . LEU A 1 195 ? 30.958 -26.545 0.930   1.00 60.63  ? 189 LEU A CA  1 
ATOM 1590 C C   . LEU A 1 195 ? 31.689 -27.769 0.387   1.00 56.59  ? 189 LEU A C   1 
ATOM 1591 O O   . LEU A 1 195 ? 32.081 -28.650 1.161   1.00 50.17  ? 189 LEU A O   1 
ATOM 1592 C CB  . LEU A 1 195 ? 29.447 -26.792 0.926   1.00 62.02  ? 189 LEU A CB  1 
ATOM 1593 C CG  . LEU A 1 195 ? 28.933 -28.035 1.658   1.00 56.46  ? 189 LEU A CG  1 
ATOM 1594 C CD1 . LEU A 1 195 ? 29.378 -28.052 3.115   1.00 59.49  ? 189 LEU A CD1 1 
ATOM 1595 C CD2 . LEU A 1 195 ? 27.422 -28.120 1.561   1.00 79.22  ? 189 LEU A CD2 1 
ATOM 1596 N N   . ILE A 1 196 ? 31.858 -27.851 -0.935  1.00 61.81  ? 190 ILE A N   1 
ATOM 1597 C CA  . ILE A 1 196 ? 32.653 -28.912 -1.540  1.00 46.84  ? 190 ILE A CA  1 
ATOM 1598 C C   . ILE A 1 196 ? 34.113 -28.780 -1.140  1.00 56.10  ? 190 ILE A C   1 
ATOM 1599 O O   . ILE A 1 196 ? 34.843 -29.780 -1.100  1.00 83.51  ? 190 ILE A O   1 
ATOM 1600 C CB  . ILE A 1 196 ? 32.461 -28.896 -3.072  1.00 46.08  ? 190 ILE A CB  1 
ATOM 1601 C CG1 . ILE A 1 196 ? 31.047 -29.358 -3.430  1.00 64.36  ? 190 ILE A CG1 1 
ATOM 1602 C CG2 . ILE A 1 196 ? 33.484 -29.770 -3.781  1.00 61.15  ? 190 ILE A CG2 1 
ATOM 1603 C CD1 . ILE A 1 196 ? 30.590 -28.966 -4.806  1.00 78.69  ? 190 ILE A CD1 1 
ATOM 1604 N N   . LYS A 1 197 ? 34.552 -27.569 -0.810  1.00 60.34  ? 191 LYS A N   1 
ATOM 1605 C CA  . LYS A 1 197 ? 35.887 -27.441 -0.206  1.00 57.52  ? 191 LYS A CA  1 
ATOM 1606 C C   . LYS A 1 197 ? 36.034 -28.203 1.142   1.00 68.26  ? 191 LYS A C   1 
ATOM 1607 O O   . LYS A 1 197 ? 37.116 -28.075 1.732   1.00 61.65  ? 191 LYS A O   1 
ATOM 1608 C CB  . LYS A 1 197 ? 36.270 -25.974 0.005   1.00 57.85  ? 191 LYS A CB  1 
ATOM 1609 C CG  . LYS A 1 197 ? 36.421 -25.151 -1.259  1.00 69.89  ? 191 LYS A CG  1 
ATOM 1610 C CD  . LYS A 1 197 ? 36.716 -23.703 -0.906  1.00 81.76  ? 191 LYS A CD  1 
ATOM 1611 C CE  . LYS A 1 197 ? 36.668 -22.815 -2.124  1.00 72.25  ? 191 LYS A CE  1 
ATOM 1612 N NZ  . LYS A 1 197 ? 36.848 -21.377 -1.789  1.00 67.63  ? 191 LYS A NZ  1 
ATOM 1613 N N   . SER A 1 198 ? 35.063 -28.962 1.664   1.00 74.69  ? 192 SER A N   1 
ATOM 1614 C CA  . SER A 1 198 ? 35.289 -29.767 2.859   1.00 55.02  ? 192 SER A CA  1 
ATOM 1615 C C   . SER A 1 198 ? 36.055 -31.048 2.558   1.00 64.06  ? 192 SER A C   1 
ATOM 1616 O O   . SER A 1 198 ? 36.576 -31.672 3.487   1.00 73.00  ? 192 SER A O   1 
ATOM 1617 C CB  . SER A 1 198 ? 33.957 -30.123 3.523   1.00 44.41  ? 192 SER A CB  1 
ATOM 1618 O OG  . SER A 1 198 ? 33.146 -30.903 2.663   1.00 47.77  ? 192 SER A OG  1 
ATOM 1619 N N   . LYS A 1 199 ? 36.120 -31.459 1.295   1.00 81.09  ? 193 LYS A N   1 
ATOM 1620 C CA  . LYS A 1 199 ? 36.875 -32.629 0.869   1.00 91.25  ? 193 LYS A CA  1 
ATOM 1621 C C   . LYS A 1 199 ? 38.051 -32.190 0.007   1.00 84.90  ? 193 LYS A C   1 
ATOM 1622 O O   . LYS A 1 199 ? 38.000 -31.148 -0.655  1.00 76.29  ? 193 LYS A O   1 
ATOM 1623 C CB  . LYS A 1 199 ? 35.993 -33.597 0.075   1.00 94.50  ? 193 LYS A CB  1 
ATOM 1624 C CG  . LYS A 1 199 ? 34.821 -34.157 0.854   1.00 100.44 ? 193 LYS A CG  1 
ATOM 1625 C CD  . LYS A 1 199 ? 34.080 -35.221 0.063   1.00 110.70 ? 193 LYS A CD  1 
ATOM 1626 C CE  . LYS A 1 199 ? 32.931 -35.798 0.877   1.00 116.82 ? 193 LYS A CE  1 
ATOM 1627 N NZ  . LYS A 1 199 ? 32.213 -36.892 0.167   1.00 106.09 ? 193 LYS A NZ  1 
ATOM 1628 N N   . CYS A 1 200 ? 39.113 -32.996 0.005   1.00 89.86  ? 194 CYS A N   1 
ATOM 1629 C CA  . CYS A 1 200 ? 40.315 -32.679 -0.758  1.00 103.40 ? 194 CYS A CA  1 
ATOM 1630 C C   . CYS A 1 200 ? 40.480 -33.553 -1.997  1.00 104.72 ? 194 CYS A C   1 
ATOM 1631 O O   . CYS A 1 200 ? 41.596 -33.687 -2.510  1.00 107.11 ? 194 CYS A O   1 
ATOM 1632 C CB  . CYS A 1 200 ? 41.556 -32.784 0.129   1.00 103.70 ? 194 CYS A CB  1 
ATOM 1633 S SG  . CYS A 1 200 ? 41.569 -31.644 1.526   1.00 103.74 ? 194 CYS A SG  1 
ATOM 1634 N N   . GLY A 1 201 ? 39.402 -34.133 -2.496  1.00 103.65 ? 195 GLY A N   1 
ATOM 1635 C CA  . GLY A 1 201 ? 39.472 -34.929 -3.704  1.00 100.51 ? 195 GLY A CA  1 
ATOM 1636 C C   . GLY A 1 201 ? 39.648 -36.408 -3.414  1.00 110.94 ? 195 GLY A C   1 
ATOM 1637 O O   . GLY A 1 201 ? 40.218 -36.811 -2.393  1.00 100.75 ? 195 GLY A O   1 
ATOM 1638 N N   . SER A 1 202 ? 39.155 -37.235 -4.332  1.00 121.96 ? 196 SER A N   1 
ATOM 1639 C CA  . SER A 1 202 ? 39.249 -38.683 -4.185  1.00 111.19 ? 196 SER A CA  1 
ATOM 1640 C C   . SER A 1 202 ? 39.942 -39.320 -5.387  1.00 98.56  ? 196 SER A C   1 
ATOM 1641 O O   . SER A 1 202 ? 39.499 -39.170 -6.526  1.00 74.50  ? 196 SER A O   1 
ATOM 1642 C CB  . SER A 1 202 ? 37.857 -39.296 -3.992  1.00 108.78 ? 196 SER A CB  1 
ATOM 1643 O OG  . SER A 1 202 ? 37.251 -38.821 -2.801  1.00 102.58 ? 196 SER A OG  1 
ATOM 1644 N N   . ILE A 1 204 ? 42.592 -32.457 -7.290  1.00 99.25  ? 198 ILE A N   1 
ATOM 1645 C CA  . ILE A 1 204 ? 43.768 -33.259 -7.599  1.00 93.50  ? 198 ILE A CA  1 
ATOM 1646 C C   . ILE A 1 204 ? 44.223 -32.995 -9.033  1.00 94.96  ? 198 ILE A C   1 
ATOM 1647 O O   . ILE A 1 204 ? 45.296 -32.435 -9.257  1.00 58.53  ? 198 ILE A O   1 
ATOM 1648 C CB  . ILE A 1 204 ? 43.494 -34.755 -7.376  1.00 65.09  ? 198 ILE A CB  1 
ATOM 1649 C CG1 . ILE A 1 204 ? 43.126 -35.022 -5.917  1.00 69.96  ? 198 ILE A CG1 1 
ATOM 1650 C CG2 . ILE A 1 204 ? 44.713 -35.575 -7.750  1.00 61.97  ? 198 ILE A CG2 1 
ATOM 1651 C CD1 . ILE A 1 204 ? 42.736 -36.456 -5.644  1.00 72.59  ? 198 ILE A CD1 1 
ATOM 1652 N N   . THR A 1 205 ? 43.404 -33.404 -10.001 1.00 109.27 ? 199 THR A N   1 
ATOM 1653 C CA  . THR A 1 205 ? 43.729 -33.167 -11.400 1.00 110.14 ? 199 THR A CA  1 
ATOM 1654 C C   . THR A 1 205 ? 43.655 -31.676 -11.711 1.00 114.56 ? 199 THR A C   1 
ATOM 1655 O O   . THR A 1 205 ? 42.834 -30.942 -11.156 1.00 115.20 ? 199 THR A O   1 
ATOM 1656 C CB  . THR A 1 205 ? 42.780 -33.936 -12.322 1.00 101.64 ? 199 THR A CB  1 
ATOM 1657 O OG1 . THR A 1 205 ? 41.438 -33.831 -11.836 1.00 97.02  ? 199 THR A OG1 1 
ATOM 1658 C CG2 . THR A 1 205 ? 43.169 -35.400 -12.370 1.00 97.67  ? 199 THR A CG2 1 
ATOM 1659 N N   . SER A 1 206 ? 44.527 -31.232 -12.616 1.00 105.56 ? 200 SER A N   1 
ATOM 1660 C CA  . SER A 1 206 ? 44.671 -29.817 -12.935 1.00 95.71  ? 200 SER A CA  1 
ATOM 1661 C C   . SER A 1 206 ? 43.576 -29.291 -13.857 1.00 92.57  ? 200 SER A C   1 
ATOM 1662 O O   . SER A 1 206 ? 43.757 -28.225 -14.458 1.00 94.26  ? 200 SER A O   1 
ATOM 1663 C CB  . SER A 1 206 ? 46.045 -29.556 -13.555 1.00 91.18  ? 200 SER A CB  1 
ATOM 1664 O OG  . SER A 1 206 ? 46.239 -30.352 -14.711 1.00 114.40 ? 200 SER A OG  1 
ATOM 1665 N N   . HIS A 1 207 ? 42.461 -30.002 -13.990 1.00 96.41  ? 201 HIS A N   1 
ATOM 1666 C CA  . HIS A 1 207 ? 41.290 -29.504 -14.700 1.00 102.83 ? 201 HIS A CA  1 
ATOM 1667 C C   . HIS A 1 207 ? 40.078 -29.408 -13.794 1.00 106.67 ? 201 HIS A C   1 
ATOM 1668 O O   . HIS A 1 207 ? 39.284 -28.470 -13.917 1.00 114.52 ? 201 HIS A O   1 
ATOM 1669 C CB  . HIS A 1 207 ? 40.982 -30.397 -15.911 1.00 105.00 ? 201 HIS A CB  1 
ATOM 1670 C CG  . HIS A 1 207 ? 42.005 -30.305 -16.995 1.00 108.74 ? 201 HIS A CG  1 
ATOM 1671 N ND1 . HIS A 1 207 ? 42.111 -29.207 -17.823 1.00 100.36 ? 201 HIS A ND1 1 
ATOM 1672 C CD2 . HIS A 1 207 ? 42.970 -31.167 -17.389 1.00 99.61  ? 201 HIS A CD2 1 
ATOM 1673 C CE1 . HIS A 1 207 ? 43.101 -29.395 -18.674 1.00 89.37  ? 201 HIS A CE1 1 
ATOM 1674 N NE2 . HIS A 1 207 ? 43.638 -30.579 -18.435 1.00 95.60  ? 201 HIS A NE2 1 
ATOM 1675 N N   . GLU A 1 208 ? 39.906 -30.383 -12.900 1.00 101.59 ? 202 GLU A N   1 
ATOM 1676 C CA  . GLU A 1 208 ? 39.033 -30.204 -11.746 1.00 119.27 ? 202 GLU A CA  1 
ATOM 1677 C C   . GLU A 1 208 ? 39.390 -28.930 -10.988 1.00 117.77 ? 202 GLU A C   1 
ATOM 1678 O O   . GLU A 1 208 ? 38.507 -28.192 -10.527 1.00 118.65 ? 202 GLU A O   1 
ATOM 1679 C CB  . GLU A 1 208 ? 39.155 -31.426 -10.837 1.00 125.24 ? 202 GLU A CB  1 
ATOM 1680 C CG  . GLU A 1 208 ? 38.519 -31.307 -9.472  1.00 123.52 ? 202 GLU A CG  1 
ATOM 1681 C CD  . GLU A 1 208 ? 39.105 -32.315 -8.501  1.00 126.57 ? 202 GLU A CD  1 
ATOM 1682 O OE1 . GLU A 1 208 ? 39.950 -33.121 -8.941  1.00 127.69 ? 202 GLU A OE1 1 
ATOM 1683 O OE2 . GLU A 1 208 ? 38.736 -32.293 -7.308  1.00 120.68 ? 202 GLU A OE2 1 
ATOM 1684 N N   . MET A 1 209 ? 40.690 -28.658 -10.865 1.00 100.49 ? 203 MET A N   1 
ATOM 1685 C CA  . MET A 1 209 ? 41.165 -27.449 -10.202 1.00 105.65 ? 203 MET A CA  1 
ATOM 1686 C C   . MET A 1 209 ? 40.591 -26.194 -10.849 1.00 99.74  ? 203 MET A C   1 
ATOM 1687 O O   . MET A 1 209 ? 40.078 -25.310 -10.156 1.00 82.94  ? 203 MET A O   1 
ATOM 1688 C CB  . MET A 1 209 ? 42.692 -27.422 -10.237 1.00 104.89 ? 203 MET A CB  1 
ATOM 1689 C CG  . MET A 1 209 ? 43.327 -26.204 -9.609  1.00 91.71  ? 203 MET A CG  1 
ATOM 1690 S SD  . MET A 1 209 ? 45.088 -26.228 -9.976  1.00 130.06 ? 203 MET A SD  1 
ATOM 1691 C CE  . MET A 1 209 ? 45.084 -25.716 -11.696 1.00 88.85  ? 203 MET A CE  1 
ATOM 1692 N N   . LEU A 1 210 ? 40.698 -26.086 -12.176 1.00 86.57  ? 204 LEU A N   1 
ATOM 1693 C CA  . LEU A 1 210 ? 40.141 -24.933 -12.879 1.00 87.45  ? 204 LEU A CA  1 
ATOM 1694 C C   . LEU A 1 210 ? 38.645 -24.822 -12.631 1.00 92.19  ? 204 LEU A C   1 
ATOM 1695 O O   . LEU A 1 210 ? 38.122 -23.735 -12.351 1.00 91.12  ? 204 LEU A O   1 
ATOM 1696 C CB  . LEU A 1 210 ? 40.418 -25.059 -14.376 1.00 93.99  ? 204 LEU A CB  1 
ATOM 1697 C CG  . LEU A 1 210 ? 41.864 -25.312 -14.802 1.00 99.12  ? 204 LEU A CG  1 
ATOM 1698 C CD1 . LEU A 1 210 ? 41.936 -25.554 -16.304 1.00 79.75  ? 204 LEU A CD1 1 
ATOM 1699 C CD2 . LEU A 1 210 ? 42.766 -24.166 -14.378 1.00 80.37  ? 204 LEU A CD2 1 
ATOM 1700 N N   . TRP A 1 211 ? 37.944 -25.951 -12.727 1.00 85.39  ? 205 TRP A N   1 
ATOM 1701 C CA  . TRP A 1 211 ? 36.493 -25.963 -12.600 1.00 80.62  ? 205 TRP A CA  1 
ATOM 1702 C C   . TRP A 1 211 ? 36.057 -25.459 -11.230 1.00 86.70  ? 205 TRP A C   1 
ATOM 1703 O O   . TRP A 1 211 ? 35.045 -24.760 -11.110 1.00 76.68  ? 205 TRP A O   1 
ATOM 1704 C CB  . TRP A 1 211 ? 35.985 -27.383 -12.849 1.00 55.08  ? 205 TRP A CB  1 
ATOM 1705 C CG  . TRP A 1 211 ? 34.518 -27.500 -13.092 1.00 62.49  ? 205 TRP A CG  1 
ATOM 1706 C CD1 . TRP A 1 211 ? 33.629 -28.249 -12.378 1.00 75.34  ? 205 TRP A CD1 1 
ATOM 1707 C CD2 . TRP A 1 211 ? 33.771 -26.898 -14.156 1.00 66.13  ? 205 TRP A CD2 1 
ATOM 1708 N NE1 . TRP A 1 211 ? 32.370 -28.128 -12.913 1.00 82.39  ? 205 TRP A NE1 1 
ATOM 1709 C CE2 . TRP A 1 211 ? 32.430 -27.305 -14.007 1.00 66.14  ? 205 TRP A CE2 1 
ATOM 1710 C CE3 . TRP A 1 211 ? 34.103 -26.044 -15.212 1.00 62.72  ? 205 TRP A CE3 1 
ATOM 1711 C CZ2 . TRP A 1 211 ? 31.422 -26.887 -14.874 1.00 61.92  ? 205 TRP A CZ2 1 
ATOM 1712 C CZ3 . TRP A 1 211 ? 33.099 -25.629 -16.071 1.00 67.25  ? 205 TRP A CZ3 1 
ATOM 1713 C CH2 . TRP A 1 211 ? 31.777 -26.051 -15.897 1.00 66.99  ? 205 TRP A CH2 1 
ATOM 1714 N N   . ARG A 1 212 ? 36.818 -25.791 -10.184 1.00 78.87  ? 206 ARG A N   1 
ATOM 1715 C CA  . ARG A 1 212 ? 36.460 -25.338 -8.842  1.00 85.01  ? 206 ARG A CA  1 
ATOM 1716 C C   . ARG A 1 212 ? 36.865 -23.880 -8.636  1.00 85.33  ? 206 ARG A C   1 
ATOM 1717 O O   . ARG A 1 212 ? 36.083 -23.063 -8.126  1.00 83.08  ? 206 ARG A O   1 
ATOM 1718 C CB  . ARG A 1 212 ? 37.126 -26.240 -7.797  1.00 93.47  ? 206 ARG A CB  1 
ATOM 1719 C CG  . ARG A 1 212 ? 36.927 -25.810 -6.348  1.00 105.29 ? 206 ARG A CG  1 
ATOM 1720 C CD  . ARG A 1 212 ? 37.654 -26.757 -5.407  1.00 103.36 ? 206 ARG A CD  1 
ATOM 1721 N NE  . ARG A 1 212 ? 37.100 -28.105 -5.439  1.00 115.08 ? 206 ARG A NE  1 
ATOM 1722 C CZ  . ARG A 1 212 ? 37.749 -29.166 -5.899  1.00 116.55 ? 206 ARG A CZ  1 
ATOM 1723 N NH1 . ARG A 1 212 ? 38.970 -29.066 -6.399  1.00 108.49 ? 206 ARG A NH1 1 
ATOM 1724 N NH2 . ARG A 1 212 ? 37.154 -30.355 -5.866  1.00 105.46 ? 206 ARG A NH2 1 
ATOM 1725 N N   . ARG A 1 213 ? 38.086 -23.533 -9.044  1.00 76.86  ? 207 ARG A N   1 
ATOM 1726 C CA  . ARG A 1 213 ? 38.601 -22.191 -8.804  1.00 79.61  ? 207 ARG A CA  1 
ATOM 1727 C C   . ARG A 1 213 ? 37.780 -21.144 -9.539  1.00 76.84  ? 207 ARG A C   1 
ATOM 1728 O O   . ARG A 1 213 ? 37.698 -19.991 -9.096  1.00 85.27  ? 207 ARG A O   1 
ATOM 1729 C CB  . ARG A 1 213 ? 40.068 -22.124 -9.223  1.00 73.10  ? 207 ARG A CB  1 
ATOM 1730 C CG  . ARG A 1 213 ? 41.016 -22.873 -8.289  1.00 66.92  ? 207 ARG A CG  1 
ATOM 1731 C CD  . ARG A 1 213 ? 40.893 -22.422 -6.844  1.00 58.46  ? 207 ARG A CD  1 
ATOM 1732 N NE  . ARG A 1 213 ? 41.292 -21.031 -6.665  1.00 67.08  ? 207 ARG A NE  1 
ATOM 1733 C CZ  . ARG A 1 213 ? 40.747 -20.198 -5.787  1.00 97.31  ? 207 ARG A CZ  1 
ATOM 1734 N NH1 . ARG A 1 213 ? 39.788 -20.589 -4.961  1.00 105.89 ? 207 ARG A NH1 1 
ATOM 1735 N NH2 . ARG A 1 213 ? 41.180 -18.941 -5.731  1.00 90.82  ? 207 ARG A NH2 1 
ATOM 1736 N N   . VAL A 1 214 ? 37.139 -21.526 -10.644 1.00 73.66  ? 208 VAL A N   1 
ATOM 1737 C CA  . VAL A 1 214 ? 36.250 -20.582 -11.315 1.00 68.67  ? 208 VAL A CA  1 
ATOM 1738 C C   . VAL A 1 214 ? 35.044 -20.263 -10.436 1.00 63.27  ? 208 VAL A C   1 
ATOM 1739 O O   . VAL A 1 214 ? 34.658 -19.097 -10.286 1.00 77.78  ? 208 VAL A O   1 
ATOM 1740 C CB  . VAL A 1 214 ? 35.825 -21.119 -12.695 1.00 71.66  ? 208 VAL A CB  1 
ATOM 1741 C CG1 . VAL A 1 214 ? 34.616 -20.360 -13.217 1.00 68.97  ? 208 VAL A CG1 1 
ATOM 1742 C CG2 . VAL A 1 214 ? 36.984 -21.033 -13.685 1.00 74.96  ? 208 VAL A CG2 1 
ATOM 1743 N N   . PHE A 1 215 ? 34.440 -21.286 -9.830  1.00 67.62  ? 209 PHE A N   1 
ATOM 1744 C CA  . PHE A 1 215 ? 33.246 -21.110 -9.011  1.00 79.62  ? 209 PHE A CA  1 
ATOM 1745 C C   . PHE A 1 215 ? 33.546 -20.588 -7.614  1.00 70.94  ? 209 PHE A C   1 
ATOM 1746 O O   . PHE A 1 215 ? 32.607 -20.292 -6.867  1.00 53.81  ? 209 PHE A O   1 
ATOM 1747 C CB  . PHE A 1 215 ? 32.487 -22.433 -8.887  1.00 62.19  ? 209 PHE A CB  1 
ATOM 1748 C CG  . PHE A 1 215 ? 31.940 -22.934 -10.184 1.00 58.21  ? 209 PHE A CG  1 
ATOM 1749 C CD1 . PHE A 1 215 ? 31.409 -22.054 -11.109 1.00 73.26  ? 209 PHE A CD1 1 
ATOM 1750 C CD2 . PHE A 1 215 ? 31.961 -24.285 -10.484 1.00 53.15  ? 209 PHE A CD2 1 
ATOM 1751 C CE1 . PHE A 1 215 ? 30.908 -22.510 -12.308 1.00 74.26  ? 209 PHE A CE1 1 
ATOM 1752 C CE2 . PHE A 1 215 ? 31.460 -24.749 -11.683 1.00 60.70  ? 209 PHE A CE2 1 
ATOM 1753 C CZ  . PHE A 1 215 ? 30.932 -23.859 -12.597 1.00 63.64  ? 209 PHE A CZ  1 
ATOM 1754 N N   . ASP A 1 216 ? 34.816 -20.482 -7.234  1.00 75.67  ? 210 ASP A N   1 
ATOM 1755 C CA  . ASP A 1 216 ? 35.179 -20.113 -5.868  1.00 77.71  ? 210 ASP A CA  1 
ATOM 1756 C C   . ASP A 1 216 ? 35.095 -18.607 -5.577  1.00 70.21  ? 210 ASP A C   1 
ATOM 1757 O O   . ASP A 1 216 ? 35.538 -18.191 -4.499  1.00 70.34  ? 210 ASP A O   1 
ATOM 1758 C CB  . ASP A 1 216 ? 36.596 -20.603 -5.559  1.00 81.56  ? 210 ASP A CB  1 
ATOM 1759 C CG  . ASP A 1 216 ? 36.657 -22.096 -5.305  1.00 96.58  ? 210 ASP A CG  1 
ATOM 1760 O OD1 . ASP A 1 216 ? 35.591 -22.715 -5.089  1.00 97.40  ? 210 ASP A OD1 1 
ATOM 1761 O OD2 . ASP A 1 216 ? 37.773 -22.653 -5.319  1.00 98.42  ? 210 ASP A OD2 1 
ATOM 1762 N N   . GLY A 1 217 ? 34.533 -17.781 -6.463  1.00 61.55  ? 211 GLY A N   1 
ATOM 1763 C CA  . GLY A 1 217 ? 34.696 -16.347 -6.278  1.00 72.89  ? 211 GLY A CA  1 
ATOM 1764 C C   . GLY A 1 217 ? 33.509 -15.414 -6.455  1.00 73.70  ? 211 GLY A C   1 
ATOM 1765 O O   . GLY A 1 217 ? 33.536 -14.297 -5.927  1.00 38.86  ? 211 GLY A O   1 
ATOM 1766 N N   . LEU A 1 218 ? 32.473 -15.838 -7.187  1.00 83.00  ? 212 LEU A N   1 
ATOM 1767 C CA  . LEU A 1 218 ? 31.341 -14.972 -7.556  1.00 52.25  ? 212 LEU A CA  1 
ATOM 1768 C C   . LEU A 1 218 ? 31.793 -13.776 -8.393  1.00 50.39  ? 212 LEU A C   1 
ATOM 1769 O O   . LEU A 1 218 ? 31.484 -12.622 -8.090  1.00 43.00  ? 212 LEU A O   1 
ATOM 1770 C CB  . LEU A 1 218 ? 30.556 -14.499 -6.330  1.00 33.15  ? 212 LEU A CB  1 
ATOM 1771 C CG  . LEU A 1 218 ? 29.686 -15.533 -5.628  1.00 44.03  ? 212 LEU A CG  1 
ATOM 1772 C CD1 . LEU A 1 218 ? 29.155 -14.972 -4.324  1.00 41.24  ? 212 LEU A CD1 1 
ATOM 1773 C CD2 . LEU A 1 218 ? 28.551 -15.960 -6.543  1.00 33.99  ? 212 LEU A CD2 1 
ATOM 1774 N N   . VAL A 1 219 ? 32.527 -14.066 -9.468  1.00 45.90  ? 213 VAL A N   1 
ATOM 1775 C CA  . VAL A 1 219 ? 32.930 -13.018 -10.399 1.00 32.24  ? 213 VAL A CA  1 
ATOM 1776 C C   . VAL A 1 219 ? 31.868 -12.803 -11.472 1.00 37.99  ? 213 VAL A C   1 
ATOM 1777 O O   . VAL A 1 219 ? 31.780 -11.709 -12.054 1.00 44.11  ? 213 VAL A O   1 
ATOM 1778 C CB  . VAL A 1 219 ? 34.295 -13.384 -11.008 1.00 40.31  ? 213 VAL A CB  1 
ATOM 1779 C CG1 . VAL A 1 219 ? 34.733 -12.369 -12.053 1.00 45.51  ? 213 VAL A CG1 1 
ATOM 1780 C CG2 . VAL A 1 219 ? 35.339 -13.539 -9.909  1.00 16.85  ? 213 VAL A CG2 1 
ATOM 1781 N N   . ILE A 1 220 ? 31.043 -13.821 -11.728 1.00 39.51  ? 214 ILE A N   1 
ATOM 1782 C CA  . ILE A 1 220 ? 29.928 -13.685 -12.660 1.00 34.30  ? 214 ILE A CA  1 
ATOM 1783 C C   . ILE A 1 220 ? 29.010 -12.547 -12.229 1.00 40.03  ? 214 ILE A C   1 
ATOM 1784 O O   . ILE A 1 220 ? 28.545 -11.752 -13.058 1.00 50.80  ? 214 ILE A O   1 
ATOM 1785 C CB  . ILE A 1 220 ? 29.166 -15.021 -12.758 1.00 34.62  ? 214 ILE A CB  1 
ATOM 1786 C CG1 . ILE A 1 220 ? 30.135 -16.154 -13.097 1.00 47.74  ? 214 ILE A CG1 1 
ATOM 1787 C CG2 . ILE A 1 220 ? 28.085 -14.942 -13.818 1.00 53.99  ? 214 ILE A CG2 1 
ATOM 1788 C CD1 . ILE A 1 220 ? 29.503 -17.531 -13.106 1.00 56.39  ? 214 ILE A CD1 1 
ATOM 1789 N N   . LEU A 1 221 ? 28.725 -12.458 -10.927 1.00 34.94  ? 215 LEU A N   1 
ATOM 1790 C CA  . LEU A 1 221 ? 27.913 -11.358 -10.421 1.00 32.97  ? 215 LEU A CA  1 
ATOM 1791 C C   . LEU A 1 221 ? 28.558 -10.012 -10.717 1.00 27.02  ? 215 LEU A C   1 
ATOM 1792 O O   . LEU A 1 221 ? 27.852 -9.026  -10.951 1.00 28.37  ? 215 LEU A O   1 
ATOM 1793 C CB  . LEU A 1 221 ? 27.677 -11.522 -8.917  1.00 41.36  ? 215 LEU A CB  1 
ATOM 1794 C CG  . LEU A 1 221 ? 27.001 -12.820 -8.472  1.00 38.70  ? 215 LEU A CG  1 
ATOM 1795 C CD1 . LEU A 1 221 ? 26.726 -12.812 -6.974  1.00 17.47  ? 215 LEU A CD1 1 
ATOM 1796 C CD2 . LEU A 1 221 ? 25.727 -13.049 -9.260  1.00 27.37  ? 215 LEU A CD2 1 
ATOM 1797 N N   . PHE A 1 222 ? 29.892 -9.953  -10.726 1.00 27.73  ? 216 PHE A N   1 
ATOM 1798 C CA  . PHE A 1 222 ? 30.566 -8.698  -11.048 1.00 23.99  ? 216 PHE A CA  1 
ATOM 1799 C C   . PHE A 1 222 ? 30.437 -8.374  -12.534 1.00 34.39  ? 216 PHE A C   1 
ATOM 1800 O O   . PHE A 1 222 ? 30.238 -7.209  -12.900 1.00 40.66  ? 216 PHE A O   1 
ATOM 1801 C CB  . PHE A 1 222 ? 32.036 -8.764  -10.625 1.00 36.91  ? 216 PHE A CB  1 
ATOM 1802 C CG  . PHE A 1 222 ? 32.246 -9.136  -9.178  1.00 38.25  ? 216 PHE A CG  1 
ATOM 1803 C CD1 . PHE A 1 222 ? 31.276 -8.870  -8.220  1.00 38.17  ? 216 PHE A CD1 1 
ATOM 1804 C CD2 . PHE A 1 222 ? 33.422 -9.753  -8.779  1.00 37.31  ? 216 PHE A CD2 1 
ATOM 1805 C CE1 . PHE A 1 222 ? 31.472 -9.218  -6.898  1.00 35.90  ? 216 PHE A CE1 1 
ATOM 1806 C CE2 . PHE A 1 222 ? 33.626 -10.101 -7.457  1.00 46.02  ? 216 PHE A CE2 1 
ATOM 1807 C CZ  . PHE A 1 222 ? 32.649 -9.831  -6.515  1.00 49.37  ? 216 PHE A CZ  1 
ATOM 1808 N N   . TYR A 1 223 ? 30.539 -9.382  -13.407 1.00 46.64  ? 217 TYR A N   1 
ATOM 1809 C CA  . TYR A 1 223 ? 30.289 -9.135  -14.827 1.00 38.00  ? 217 TYR A CA  1 
ATOM 1810 C C   . TYR A 1 223 ? 28.857 -8.686  -15.101 1.00 29.36  ? 217 TYR A C   1 
ATOM 1811 O O   . TYR A 1 223 ? 28.623 -7.929  -16.048 1.00 23.53  ? 217 TYR A O   1 
ATOM 1812 C CB  . TYR A 1 223 ? 30.626 -10.364 -15.678 1.00 35.36  ? 217 TYR A CB  1 
ATOM 1813 C CG  . TYR A 1 223 ? 32.105 -10.679 -15.752 1.00 40.83  ? 217 TYR A CG  1 
ATOM 1814 C CD1 . TYR A 1 223 ? 33.040 -9.660  -15.717 1.00 59.67  ? 217 TYR A CD1 1 
ATOM 1815 C CD2 . TYR A 1 223 ? 32.566 -11.980 -15.897 1.00 41.59  ? 217 TYR A CD2 1 
ATOM 1816 C CE1 . TYR A 1 223 ? 34.391 -9.917  -15.808 1.00 55.03  ? 217 TYR A CE1 1 
ATOM 1817 C CE2 . TYR A 1 223 ? 33.925 -12.251 -15.985 1.00 46.18  ? 217 TYR A CE2 1 
ATOM 1818 C CZ  . TYR A 1 223 ? 34.830 -11.210 -15.940 1.00 43.49  ? 217 TYR A CZ  1 
ATOM 1819 O OH  . TYR A 1 223 ? 36.179 -11.453 -16.022 1.00 33.88  ? 217 TYR A OH  1 
ATOM 1820 N N   . GLN A 1 224 ? 27.888 -9.137  -14.300 1.00 39.22  ? 218 GLN A N   1 
ATOM 1821 C CA  . GLN A 1 224 ? 26.509 -8.714  -14.551 1.00 29.13  ? 218 GLN A CA  1 
ATOM 1822 C C   . GLN A 1 224 ? 26.273 -7.234  -14.261 1.00 34.54  ? 218 GLN A C   1 
ATOM 1823 O O   . GLN A 1 224 ? 25.256 -6.692  -14.710 1.00 33.09  ? 218 GLN A O   1 
ATOM 1824 C CB  . GLN A 1 224 ? 25.524 -9.559  -13.742 1.00 33.41  ? 218 GLN A CB  1 
ATOM 1825 C CG  . GLN A 1 224 ? 25.474 -11.016 -14.159 1.00 52.21  ? 218 GLN A CG  1 
ATOM 1826 C CD  . GLN A 1 224 ? 24.423 -11.801 -13.403 1.00 65.86  ? 218 GLN A CD  1 
ATOM 1827 O OE1 . GLN A 1 224 ? 23.235 -11.721 -13.709 1.00 44.72  ? 218 GLN A OE1 1 
ATOM 1828 N NE2 . GLN A 1 224 ? 24.855 -12.562 -12.407 1.00 70.62  ? 218 GLN A NE2 1 
ATOM 1829 N N   . PHE A 1 225 ? 27.173 -6.574  -13.525 1.00 37.30  ? 219 PHE A N   1 
ATOM 1830 C CA  . PHE A 1 225 ? 27.020 -5.140  -13.272 1.00 29.98  ? 219 PHE A CA  1 
ATOM 1831 C C   . PHE A 1 225 ? 27.001 -4.349  -14.575 1.00 36.71  ? 219 PHE A C   1 
ATOM 1832 O O   . PHE A 1 225 ? 26.149 -3.474  -14.768 1.00 35.64  ? 219 PHE A O   1 
ATOM 1833 C CB  . PHE A 1 225 ? 28.143 -4.625  -12.367 1.00 26.11  ? 219 PHE A CB  1 
ATOM 1834 C CG  . PHE A 1 225 ? 28.153 -5.219  -10.989 1.00 31.82  ? 219 PHE A CG  1 
ATOM 1835 C CD1 . PHE A 1 225 ? 27.084 -5.962  -10.521 1.00 34.44  ? 219 PHE A CD1 1 
ATOM 1836 C CD2 . PHE A 1 225 ? 29.232 -5.002  -10.146 1.00 39.01  ? 219 PHE A CD2 1 
ATOM 1837 C CE1 . PHE A 1 225 ? 27.100 -6.494  -9.245  1.00 37.52  ? 219 PHE A CE1 1 
ATOM 1838 C CE2 . PHE A 1 225 ? 29.252 -5.529  -8.871  1.00 34.33  ? 219 PHE A CE2 1 
ATOM 1839 C CZ  . PHE A 1 225 ? 28.186 -6.275  -8.420  1.00 35.38  ? 219 PHE A CZ  1 
ATOM 1840 N N   . GLY A 1 226 ? 27.945 -4.634  -15.474 1.00 30.61  ? 220 GLY A N   1 
ATOM 1841 C CA  . GLY A 1 226 ? 27.984 -3.927  -16.745 1.00 22.54  ? 220 GLY A CA  1 
ATOM 1842 C C   . GLY A 1 226 ? 26.775 -4.211  -17.612 1.00 33.10  ? 220 GLY A C   1 
ATOM 1843 O O   . GLY A 1 226 ? 26.292 -3.332  -18.327 1.00 49.92  ? 220 GLY A O   1 
ATOM 1844 N N   . GLU A 1 227 ? 26.275 -5.448  -17.574 1.00 39.59  ? 221 GLU A N   1 
ATOM 1845 C CA  . GLU A 1 227 ? 25.026 -5.769  -18.258 1.00 39.82  ? 221 GLU A CA  1 
ATOM 1846 C C   . GLU A 1 227 ? 23.882 -4.906  -17.741 1.00 36.94  ? 221 GLU A C   1 
ATOM 1847 O O   . GLU A 1 227 ? 23.145 -4.294  -18.521 1.00 38.10  ? 221 GLU A O   1 
ATOM 1848 C CB  . GLU A 1 227 ? 24.678 -7.245  -18.064 1.00 48.19  ? 221 GLU A CB  1 
ATOM 1849 C CG  . GLU A 1 227 ? 25.644 -8.233  -18.676 1.00 63.64  ? 221 GLU A CG  1 
ATOM 1850 C CD  . GLU A 1 227 ? 25.270 -9.666  -18.352 1.00 62.29  ? 221 GLU A CD  1 
ATOM 1851 O OE1 . GLU A 1 227 ? 24.112 -10.049 -18.633 1.00 43.74  ? 221 GLU A OE1 1 
ATOM 1852 O OE2 . GLU A 1 227 ? 26.136 -10.409 -17.841 1.00 50.74  ? 221 GLU A OE2 1 
ATOM 1853 N N   . LEU A 1 228 ? 23.710 -4.862  -16.419 1.00 33.98  ? 222 LEU A N   1 
ATOM 1854 C CA  . LEU A 1 228 ? 22.565 -4.163  -15.843 1.00 42.34  ? 222 LEU A CA  1 
ATOM 1855 C C   . LEU A 1 228 ? 22.658 -2.663  -16.073 1.00 32.71  ? 222 LEU A C   1 
ATOM 1856 O O   . LEU A 1 228 ? 21.687 -2.031  -16.505 1.00 30.43  ? 222 LEU A O   1 
ATOM 1857 C CB  . LEU A 1 228 ? 22.466 -4.467  -14.351 1.00 45.39  ? 222 LEU A CB  1 
ATOM 1858 C CG  . LEU A 1 228 ? 22.108 -5.912  -14.022 1.00 20.68  ? 222 LEU A CG  1 
ATOM 1859 C CD1 . LEU A 1 228 ? 22.474 -6.215  -12.586 1.00 35.30  ? 222 LEU A CD1 1 
ATOM 1860 C CD2 . LEU A 1 228 ? 20.638 -6.141  -14.276 1.00 18.58  ? 222 LEU A CD2 1 
ATOM 1861 N N   . ILE A 1 229 ? 23.819 -2.074  -15.789 1.00 30.37  ? 223 ILE A N   1 
ATOM 1862 C CA  . ILE A 1 229 ? 23.953 -0.627  -15.871 1.00 32.92  ? 223 ILE A CA  1 
ATOM 1863 C C   . ILE A 1 229 ? 23.876 -0.129  -17.310 1.00 30.48  ? 223 ILE A C   1 
ATOM 1864 O O   . ILE A 1 229 ? 23.633 1.063   -17.535 1.00 35.85  ? 223 ILE A O   1 
ATOM 1865 C CB  . ILE A 1 229 ? 25.264 -0.183  -15.197 1.00 27.16  ? 223 ILE A CB  1 
ATOM 1866 C CG1 . ILE A 1 229 ? 25.185 1.292   -14.813 1.00 35.13  ? 223 ILE A CG1 1 
ATOM 1867 C CG2 . ILE A 1 229 ? 26.453 -0.413  -16.121 1.00 51.64  ? 223 ILE A CG2 1 
ATOM 1868 C CD1 . ILE A 1 229 ? 26.343 1.758   -13.970 1.00 43.59  ? 223 ILE A CD1 1 
ATOM 1869 N N   . SER A 1 230 ? 24.065 -1.003  -18.297 1.00 26.38  ? 224 SER A N   1 
ATOM 1870 C CA  . SER A 1 230 ? 23.980 -0.600  -19.694 1.00 41.02  ? 224 SER A CA  1 
ATOM 1871 C C   . SER A 1 230 ? 22.643 -0.951  -20.333 1.00 44.69  ? 224 SER A C   1 
ATOM 1872 O O   . SER A 1 230 ? 22.456 -0.689  -21.525 1.00 50.56  ? 224 SER A O   1 
ATOM 1873 C CB  . SER A 1 230 ? 25.121 -1.225  -20.507 1.00 38.86  ? 224 SER A CB  1 
ATOM 1874 O OG  . SER A 1 230 ? 24.989 -2.632  -20.602 1.00 43.42  ? 224 SER A OG  1 
ATOM 1875 N N   . GLY A 1 231 ? 21.717 -1.533  -19.580 1.00 46.71  ? 225 GLY A N   1 
ATOM 1876 C CA  . GLY A 1 231 ? 20.404 -1.867  -20.111 1.00 40.89  ? 225 GLY A CA  1 
ATOM 1877 C C   . GLY A 1 231 ? 20.403 -2.911  -21.206 1.00 33.77  ? 225 GLY A C   1 
ATOM 1878 O O   . GLY A 1 231 ? 19.607 -2.813  -22.149 1.00 38.90  ? 225 GLY A O   1 
ATOM 1879 N N   . ALA A 1 232 ? 21.272 -3.917  -21.103 1.00 22.52  ? 226 ALA A N   1 
ATOM 1880 C CA  . ALA A 1 232 ? 21.370 -4.965  -22.110 1.00 33.05  ? 226 ALA A CA  1 
ATOM 1881 C C   . ALA A 1 232 ? 20.899 -6.320  -21.591 1.00 44.39  ? 226 ALA A C   1 
ATOM 1882 O O   . ALA A 1 232 ? 21.320 -7.358  -22.112 1.00 45.80  ? 226 ALA A O   1 
ATOM 1883 C CB  . ALA A 1 232 ? 22.804 -5.068  -22.629 1.00 43.49  ? 226 ALA A CB  1 
ATOM 1884 N N   . THR A 1 233 ? 20.033 -6.327  -20.573 1.00 41.98  ? 227 THR A N   1 
ATOM 1885 C CA  . THR A 1 233 ? 19.556 -7.584  -20.000 1.00 39.63  ? 227 THR A CA  1 
ATOM 1886 C C   . THR A 1 233 ? 18.823 -8.426  -21.038 1.00 33.66  ? 227 THR A C   1 
ATOM 1887 O O   . THR A 1 233 ? 18.945 -9.657  -21.054 1.00 40.46  ? 227 THR A O   1 
ATOM 1888 C CB  . THR A 1 233 ? 18.645 -7.298  -18.803 1.00 50.41  ? 227 THR A CB  1 
ATOM 1889 O OG1 . THR A 1 233 ? 19.407 -6.689  -17.753 1.00 67.66  ? 227 THR A OG1 1 
ATOM 1890 C CG2 . THR A 1 233 ? 18.002 -8.587  -18.287 1.00 36.99  ? 227 THR A CG2 1 
ATOM 1891 N N   . GLU A 1 234 ? 18.067 -7.779  -21.923 1.00 32.12  ? 228 GLU A N   1 
ATOM 1892 C CA  . GLU A 1 234 ? 17.311 -8.516  -22.928 1.00 37.05  ? 228 GLU A CA  1 
ATOM 1893 C C   . GLU A 1 234 ? 18.219 -9.090  -24.009 1.00 48.32  ? 228 GLU A C   1 
ATOM 1894 O O   . GLU A 1 234 ? 18.028 -10.234 -24.439 1.00 44.71  ? 228 GLU A O   1 
ATOM 1895 C CB  . GLU A 1 234 ? 16.253 -7.610  -23.551 1.00 33.17  ? 228 GLU A CB  1 
ATOM 1896 C CG  . GLU A 1 234 ? 15.459 -8.269  -24.662 1.00 45.46  ? 228 GLU A CG  1 
ATOM 1897 C CD  . GLU A 1 234 ? 14.292 -7.422  -25.111 1.00 48.44  ? 228 GLU A CD  1 
ATOM 1898 O OE1 . GLU A 1 234 ? 14.150 -6.301  -24.584 1.00 56.91  ? 228 GLU A OE1 1 
ATOM 1899 O OE2 . GLU A 1 234 ? 13.518 -7.873  -25.982 1.00 47.32  ? 228 GLU A OE2 1 
ATOM 1900 N N   . THR A 1 235 ? 19.207 -8.316  -24.461 1.00 48.74  ? 229 THR A N   1 
ATOM 1901 C CA  . THR A 1 235 ? 20.109 -8.793  -25.500 1.00 50.37  ? 229 THR A CA  1 
ATOM 1902 C C   . THR A 1 235 ? 21.153 -9.764  -24.970 1.00 44.53  ? 229 THR A C   1 
ATOM 1903 O O   . THR A 1 235 ? 21.739 -10.514 -25.758 1.00 52.54  ? 229 THR A O   1 
ATOM 1904 C CB  . THR A 1 235 ? 20.801 -7.616  -26.190 1.00 52.99  ? 229 THR A CB  1 
ATOM 1905 O OG1 . THR A 1 235 ? 21.322 -6.713  -25.208 1.00 70.53  ? 229 THR A OG1 1 
ATOM 1906 C CG2 . THR A 1 235 ? 19.816 -6.876  -27.083 1.00 54.55  ? 229 THR A CG2 1 
ATOM 1907 N N   . ALA A 1 236 ? 21.405 -9.767  -23.662 1.00 38.39  ? 230 ALA A N   1 
ATOM 1908 C CA  . ALA A 1 236 ? 22.224 -10.807 -23.059 1.00 33.90  ? 230 ALA A CA  1 
ATOM 1909 C C   . ALA A 1 236 ? 21.430 -12.071 -22.782 1.00 42.90  ? 230 ALA A C   1 
ATOM 1910 O O   . ALA A 1 236 ? 22.026 -13.145 -22.633 1.00 45.87  ? 230 ALA A O   1 
ATOM 1911 C CB  . ALA A 1 236 ? 22.858 -10.306 -21.758 1.00 46.33  ? 230 ALA A CB  1 
ATOM 1912 N N   . GLN A 1 237 ? 20.101 -11.962 -22.706 1.00 49.77  ? 231 GLN A N   1 
ATOM 1913 C CA  . GLN A 1 237 ? 19.243 -13.125 -22.558 1.00 40.32  ? 231 GLN A CA  1 
ATOM 1914 C C   . GLN A 1 237 ? 18.846 -13.718 -23.900 1.00 47.64  ? 231 GLN A C   1 
ATOM 1915 O O   . GLN A 1 237 ? 18.350 -14.850 -23.943 1.00 65.56  ? 231 GLN A O   1 
ATOM 1916 C CB  . GLN A 1 237 ? 17.987 -12.763 -21.763 1.00 38.86  ? 231 GLN A CB  1 
ATOM 1917 C CG  . GLN A 1 237 ? 18.230 -12.692 -20.264 1.00 54.62  ? 231 GLN A CG  1 
ATOM 1918 C CD  . GLN A 1 237 ? 18.525 -14.043 -19.651 1.00 55.74  ? 231 GLN A CD  1 
ATOM 1919 O OE1 . GLN A 1 237 ? 17.848 -15.032 -19.934 1.00 49.34  ? 231 GLN A OE1 1 
ATOM 1920 N NE2 . GLN A 1 237 ? 19.548 -14.094 -18.807 1.00 49.34  ? 231 GLN A NE2 1 
ATOM 1921 N N   . GLN A 1 238 ? 19.034 -12.969 -24.991 1.00 45.59  ? 232 GLN A N   1 
ATOM 1922 C CA  . GLN A 1 238 ? 18.942 -13.542 -26.327 1.00 48.02  ? 232 GLN A CA  1 
ATOM 1923 C C   . GLN A 1 238 ? 20.200 -14.313 -26.688 1.00 37.26  ? 232 GLN A C   1 
ATOM 1924 O O   . GLN A 1 238 ? 20.190 -15.093 -27.648 1.00 37.57  ? 232 GLN A O   1 
ATOM 1925 C CB  . GLN A 1 238 ? 18.710 -12.444 -27.368 1.00 53.66  ? 232 GLN A CB  1 
ATOM 1926 C CG  . GLN A 1 238 ? 17.342 -11.780 -27.305 1.00 87.70  ? 232 GLN A CG  1 
ATOM 1927 C CD  . GLN A 1 238 ? 17.294 -10.470 -28.073 1.00 97.20  ? 232 GLN A CD  1 
ATOM 1928 O OE1 . GLN A 1 238 ? 18.282 -10.058 -28.683 1.00 67.03  ? 232 GLN A OE1 1 
ATOM 1929 N NE2 . GLN A 1 238 ? 16.147 -9.801  -28.031 1.00 102.85 ? 232 GLN A NE2 1 
ATOM 1930 N N   . HIS A 1 239 ? 21.275 -14.106 -25.936 1.00 36.82  ? 233 HIS A N   1 
ATOM 1931 C CA  . HIS A 1 239 ? 22.570 -14.715 -26.194 1.00 38.81  ? 233 HIS A CA  1 
ATOM 1932 C C   . HIS A 1 239 ? 23.182 -15.160 -24.870 1.00 37.82  ? 233 HIS A C   1 
ATOM 1933 O O   . HIS A 1 239 ? 24.296 -14.776 -24.519 1.00 43.79  ? 233 HIS A O   1 
ATOM 1934 C CB  . HIS A 1 239 ? 23.508 -13.739 -26.909 1.00 37.66  ? 233 HIS A CB  1 
ATOM 1935 C CG  . HIS A 1 239 ? 23.015 -13.274 -28.243 1.00 28.57  ? 233 HIS A CG  1 
ATOM 1936 N ND1 . HIS A 1 239 ? 23.161 -14.020 -29.396 1.00 37.18  ? 233 HIS A ND1 1 
ATOM 1937 C CD2 . HIS A 1 239 ? 22.407 -12.125 -28.618 1.00 17.46  ? 233 HIS A CD2 1 
ATOM 1938 C CE1 . HIS A 1 239 ? 22.650 -13.356 -30.415 1.00 35.00  ? 233 HIS A CE1 1 
ATOM 1939 N NE2 . HIS A 1 239 ? 22.184 -12.201 -29.970 1.00 18.67  ? 233 HIS A NE2 1 
ATOM 1940 N N   . ILE A 1 240 ? 22.440 -15.959 -24.097 1.00 46.06  ? 234 ILE A N   1 
ATOM 1941 C CA  . ILE A 1 240 ? 22.933 -16.360 -22.781 1.00 33.06  ? 234 ILE A CA  1 
ATOM 1942 C C   . ILE A 1 240 ? 24.180 -17.227 -22.927 1.00 43.49  ? 234 ILE A C   1 
ATOM 1943 O O   . ILE A 1 240 ? 25.163 -17.051 -22.197 1.00 60.04  ? 234 ILE A O   1 
ATOM 1944 C CB  . ILE A 1 240 ? 21.832 -17.079 -21.982 1.00 44.26  ? 234 ILE A CB  1 
ATOM 1945 C CG1 . ILE A 1 240 ? 20.491 -16.377 -22.180 1.00 69.50  ? 234 ILE A CG1 1 
ATOM 1946 C CG2 . ILE A 1 240 ? 22.170 -17.064 -20.507 1.00 41.17  ? 234 ILE A CG2 1 
ATOM 1947 C CD1 . ILE A 1 240 ? 19.304 -17.203 -21.750 1.00 79.84  ? 234 ILE A CD1 1 
ATOM 1948 N N   . THR A 1 241 ? 24.160 -18.169 -23.865 1.00 43.11  ? 235 THR A N   1 
ATOM 1949 C CA  . THR A 1 241 ? 25.381 -18.846 -24.263 1.00 36.83  ? 235 THR A CA  1 
ATOM 1950 C C   . THR A 1 241 ? 26.329 -17.846 -24.916 1.00 40.63  ? 235 THR A C   1 
ATOM 1951 O O   . THR A 1 241 ? 25.938 -16.738 -25.295 1.00 36.12  ? 235 THR A O   1 
ATOM 1952 C CB  . THR A 1 241 ? 25.087 -19.990 -25.236 1.00 35.69  ? 235 THR A CB  1 
ATOM 1953 O OG1 . THR A 1 241 ? 24.268 -19.511 -26.310 1.00 45.89  ? 235 THR A OG1 1 
ATOM 1954 C CG2 . THR A 1 241 ? 24.362 -21.123 -24.526 1.00 30.37  ? 235 THR A CG2 1 
ATOM 1955 N N   . VAL A 1 242 ? 27.593 -18.250 -25.030 1.00 38.42  ? 236 VAL A N   1 
ATOM 1956 C CA  . VAL A 1 242 ? 28.684 -17.414 -25.531 1.00 36.00  ? 236 VAL A CA  1 
ATOM 1957 C C   . VAL A 1 242 ? 28.989 -16.300 -24.539 1.00 36.78  ? 236 VAL A C   1 
ATOM 1958 O O   . VAL A 1 242 ? 30.145 -16.111 -24.153 1.00 43.51  ? 236 VAL A O   1 
ATOM 1959 C CB  . VAL A 1 242 ? 28.395 -16.835 -26.928 1.00 40.67  ? 236 VAL A CB  1 
ATOM 1960 C CG1 . VAL A 1 242 ? 29.513 -15.900 -27.334 1.00 31.37  ? 236 VAL A CG1 1 
ATOM 1961 C CG2 . VAL A 1 242 ? 28.245 -17.955 -27.949 1.00 57.96  ? 236 VAL A CG2 1 
ATOM 1962 N N   . VAL A 1 243 ? 27.967 -15.556 -24.110 1.00 33.94  ? 237 VAL A N   1 
ATOM 1963 C CA  . VAL A 1 243 ? 28.178 -14.568 -23.054 1.00 23.00  ? 237 VAL A CA  1 
ATOM 1964 C C   . VAL A 1 243 ? 28.571 -15.258 -21.753 1.00 27.31  ? 237 VAL A C   1 
ATOM 1965 O O   . VAL A 1 243 ? 29.522 -14.847 -21.074 1.00 36.68  ? 237 VAL A O   1 
ATOM 1966 C CB  . VAL A 1 243 ? 26.928 -13.688 -22.877 1.00 13.64  ? 237 VAL A CB  1 
ATOM 1967 C CG1 . VAL A 1 243 ? 27.125 -12.722 -21.727 1.00 29.99  ? 237 VAL A CG1 1 
ATOM 1968 C CG2 . VAL A 1 243 ? 26.668 -12.910 -24.156 1.00 29.08  ? 237 VAL A CG2 1 
ATOM 1969 N N   . THR A 1 244 ? 27.869 -16.338 -21.398 1.00 29.23  ? 238 THR A N   1 
ATOM 1970 C CA  . THR A 1 244 ? 28.222 -17.080 -20.191 1.00 29.87  ? 238 THR A CA  1 
ATOM 1971 C C   . THR A 1 244 ? 29.602 -17.715 -20.322 1.00 24.47  ? 238 THR A C   1 
ATOM 1972 O O   . THR A 1 244 ? 30.367 -17.770 -19.354 1.00 19.40  ? 238 THR A O   1 
ATOM 1973 C CB  . THR A 1 244 ? 27.164 -18.147 -19.900 1.00 35.02  ? 238 THR A CB  1 
ATOM 1974 O OG1 . THR A 1 244 ? 25.886 -17.524 -19.715 1.00 32.22  ? 238 THR A OG1 1 
ATOM 1975 C CG2 . THR A 1 244 ? 27.522 -18.933 -18.644 1.00 34.32  ? 238 THR A CG2 1 
ATOM 1976 N N   . GLU A 1 245 ? 29.948 -18.184 -21.521 1.00 31.65  ? 239 GLU A N   1 
ATOM 1977 C CA  . GLU A 1 245 ? 31.266 -18.782 -21.726 1.00 25.55  ? 239 GLU A CA  1 
ATOM 1978 C C   . GLU A 1 245 ? 32.374 -17.739 -21.614 1.00 22.26  ? 239 GLU A C   1 
ATOM 1979 O O   . GLU A 1 245 ? 33.435 -18.005 -21.035 1.00 31.12  ? 239 GLU A O   1 
ATOM 1980 C CB  . GLU A 1 245 ? 31.317 -19.471 -23.089 1.00 36.86  ? 239 GLU A CB  1 
ATOM 1981 C CG  . GLU A 1 245 ? 30.280 -20.568 -23.248 1.00 50.18  ? 239 GLU A CG  1 
ATOM 1982 C CD  . GLU A 1 245 ? 30.381 -21.270 -24.584 1.00 62.63  ? 239 GLU A CD  1 
ATOM 1983 O OE1 . GLU A 1 245 ? 31.292 -22.108 -24.747 1.00 54.78  ? 239 GLU A OE1 1 
ATOM 1984 O OE2 . GLU A 1 245 ? 29.547 -20.982 -25.471 1.00 102.75 ? 239 GLU A OE2 1 
ATOM 1985 N N   . LEU A 1 246 ? 32.147 -16.547 -22.165 1.00 19.95  ? 240 LEU A N   1 
ATOM 1986 C CA  . LEU A 1 246 ? 33.123 -15.470 -22.050 1.00 23.44  ? 240 LEU A CA  1 
ATOM 1987 C C   . LEU A 1 246 ? 33.280 -15.031 -20.601 1.00 24.53  ? 240 LEU A C   1 
ATOM 1988 O O   . LEU A 1 246 ? 34.391 -14.736 -20.148 1.00 23.36  ? 240 LEU A O   1 
ATOM 1989 C CB  . LEU A 1 246 ? 32.692 -14.288 -22.917 1.00 30.08  ? 240 LEU A CB  1 
ATOM 1990 C CG  . LEU A 1 246 ? 32.876 -14.444 -24.424 1.00 37.00  ? 240 LEU A CG  1 
ATOM 1991 C CD1 . LEU A 1 246 ? 32.016 -13.423 -25.141 1.00 40.44  ? 240 LEU A CD1 1 
ATOM 1992 C CD2 . LEU A 1 246 ? 34.334 -14.311 -24.831 1.00 45.30  ? 240 LEU A CD2 1 
ATOM 1993 N N   . ARG A 1 247 ? 32.172 -14.982 -19.858 1.00 27.13  ? 241 ARG A N   1 
ATOM 1994 C CA  . ARG A 1 247 ? 32.242 -14.643 -18.441 1.00 18.80  ? 241 ARG A CA  1 
ATOM 1995 C C   . ARG A 1 247 ? 32.957 -15.729 -17.640 1.00 24.06  ? 241 ARG A C   1 
ATOM 1996 O O   . ARG A 1 247 ? 33.681 -15.417 -16.690 1.00 24.87  ? 241 ARG A O   1 
ATOM 1997 C CB  . ARG A 1 247 ? 30.826 -14.381 -17.913 1.00 19.48  ? 241 ARG A CB  1 
ATOM 1998 C CG  . ARG A 1 247 ? 30.231 -13.058 -18.408 1.00 25.33  ? 241 ARG A CG  1 
ATOM 1999 C CD  . ARG A 1 247 ? 28.850 -12.768 -17.825 1.00 35.49  ? 241 ARG A CD  1 
ATOM 2000 N NE  . ARG A 1 247 ? 27.911 -13.851 -18.093 1.00 56.84  ? 241 ARG A NE  1 
ATOM 2001 C CZ  . ARG A 1 247 ? 26.749 -14.013 -17.474 1.00 69.30  ? 241 ARG A CZ  1 
ATOM 2002 N NH1 . ARG A 1 247 ? 26.342 -13.170 -16.536 1.00 56.89  ? 241 ARG A NH1 1 
ATOM 2003 N NH2 . ARG A 1 247 ? 25.976 -15.046 -17.805 1.00 65.00  ? 241 ARG A NH2 1 
ATOM 2004 N N   . MET A 1 248 ? 32.800 -16.999 -18.025 1.00 35.55  ? 242 MET A N   1 
ATOM 2005 C CA  . MET A 1 248 ? 33.556 -18.074 -17.387 1.00 31.18  ? 242 MET A CA  1 
ATOM 2006 C C   . MET A 1 248 ? 35.049 -17.937 -17.663 1.00 29.11  ? 242 MET A C   1 
ATOM 2007 O O   . MET A 1 248 ? 35.875 -18.127 -16.762 1.00 43.12  ? 242 MET A O   1 
ATOM 2008 C CB  . MET A 1 248 ? 33.043 -19.430 -17.875 1.00 34.57  ? 242 MET A CB  1 
ATOM 2009 C CG  . MET A 1 248 ? 31.675 -19.807 -17.343 1.00 35.05  ? 242 MET A CG  1 
ATOM 2010 S SD  . MET A 1 248 ? 31.663 -20.152 -15.579 1.00 50.84  ? 242 MET A SD  1 
ATOM 2011 C CE  . MET A 1 248 ? 32.353 -21.804 -15.574 1.00 63.80  ? 242 MET A CE  1 
ATOM 2012 N N   . LEU A 1 249 ? 35.413 -17.635 -18.912 1.00 18.50  ? 243 LEU A N   1 
ATOM 2013 C CA  . LEU A 1 249 ? 36.813 -17.383 -19.243 1.00 24.60  ? 243 LEU A CA  1 
ATOM 2014 C C   . LEU A 1 249 ? 37.362 -16.210 -18.440 1.00 30.12  ? 243 LEU A C   1 
ATOM 2015 O O   . LEU A 1 249 ? 38.505 -16.242 -17.968 1.00 30.26  ? 243 LEU A O   1 
ATOM 2016 C CB  . LEU A 1 249 ? 36.959 -17.121 -20.743 1.00 30.60  ? 243 LEU A CB  1 
ATOM 2017 C CG  . LEU A 1 249 ? 36.779 -18.330 -21.661 1.00 22.83  ? 243 LEU A CG  1 
ATOM 2018 C CD1 . LEU A 1 249 ? 36.621 -17.881 -23.108 1.00 16.82  ? 243 LEU A CD1 1 
ATOM 2019 C CD2 . LEU A 1 249 ? 37.931 -19.313 -21.511 1.00 22.27  ? 243 LEU A CD2 1 
ATOM 2020 N N   . GLY A 1 250 ? 36.549 -15.170 -18.260 1.00 30.25  ? 244 GLY A N   1 
ATOM 2021 C CA  . GLY A 1 250 ? 36.980 -14.041 -17.452 1.00 24.58  ? 244 GLY A CA  1 
ATOM 2022 C C   . GLY A 1 250 ? 37.150 -14.394 -15.987 1.00 31.70  ? 244 GLY A C   1 
ATOM 2023 O O   . GLY A 1 250 ? 38.055 -13.889 -15.317 1.00 43.20  ? 244 GLY A O   1 
ATOM 2024 N N   . CYS A 1 251 ? 36.270 -15.250 -15.464 1.00 32.37  ? 245 CYS A N   1 
ATOM 2025 C CA  . CYS A 1 251 ? 36.422 -15.740 -14.097 1.00 29.59  ? 245 CYS A CA  1 
ATOM 2026 C C   . CYS A 1 251 ? 37.719 -16.521 -13.937 1.00 41.50  ? 245 CYS A C   1 
ATOM 2027 O O   . CYS A 1 251 ? 38.437 -16.354 -12.946 1.00 37.90  ? 245 CYS A O   1 
ATOM 2028 C CB  . CYS A 1 251 ? 35.230 -16.619 -13.713 1.00 35.24  ? 245 CYS A CB  1 
ATOM 2029 S SG  . CYS A 1 251 ? 33.657 -15.746 -13.636 1.00 36.57  ? 245 CYS A SG  1 
ATOM 2030 N N   . LEU A 1 252 ? 38.022 -17.393 -14.901 1.00 43.71  ? 246 LEU A N   1 
ATOM 2031 C CA  . LEU A 1 252 ? 39.290 -18.119 -14.882 1.00 33.03  ? 246 LEU A CA  1 
ATOM 2032 C C   . LEU A 1 252 ? 40.471 -17.158 -14.902 1.00 24.94  ? 246 LEU A C   1 
ATOM 2033 O O   . LEU A 1 252 ? 41.463 -17.358 -14.192 1.00 20.46  ? 246 LEU A O   1 
ATOM 2034 C CB  . LEU A 1 252 ? 39.357 -19.073 -16.076 1.00 22.56  ? 246 LEU A CB  1 
ATOM 2035 C CG  . LEU A 1 252 ? 40.589 -19.969 -16.197 1.00 29.39  ? 246 LEU A CG  1 
ATOM 2036 C CD1 . LEU A 1 252 ? 40.755 -20.823 -14.954 1.00 30.82  ? 246 LEU A CD1 1 
ATOM 2037 C CD2 . LEU A 1 252 ? 40.507 -20.834 -17.452 1.00 31.39  ? 246 LEU A CD2 1 
ATOM 2038 N N   . TYR A 1 253 ? 40.375 -16.107 -15.714 1.00 27.46  ? 247 TYR A N   1 
ATOM 2039 C CA  . TYR A 1 253 ? 41.424 -15.095 -15.791 1.00 35.41  ? 247 TYR A CA  1 
ATOM 2040 C C   . TYR A 1 253 ? 41.641 -14.441 -14.425 1.00 31.13  ? 247 TYR A C   1 
ATOM 2041 O O   . TYR A 1 253 ? 42.765 -14.403 -13.896 1.00 36.84  ? 247 TYR A O   1 
ATOM 2042 C CB  . TYR A 1 253 ? 41.003 -14.062 -16.844 1.00 39.45  ? 247 TYR A CB  1 
ATOM 2043 C CG  . TYR A 1 253 ? 42.043 -13.075 -17.325 1.00 31.99  ? 247 TYR A CG  1 
ATOM 2044 C CD1 . TYR A 1 253 ? 42.854 -13.382 -18.409 1.00 26.67  ? 247 TYR A CD1 1 
ATOM 2045 C CD2 . TYR A 1 253 ? 42.195 -11.835 -16.729 1.00 33.38  ? 247 TYR A CD2 1 
ATOM 2046 C CE1 . TYR A 1 253 ? 43.797 -12.498 -18.876 1.00 19.41  ? 247 TYR A CE1 1 
ATOM 2047 C CE2 . TYR A 1 253 ? 43.146 -10.936 -17.193 1.00 27.87  ? 247 TYR A CE2 1 
ATOM 2048 C CZ  . TYR A 1 253 ? 43.944 -11.280 -18.267 1.00 19.97  ? 247 TYR A CZ  1 
ATOM 2049 O OH  . TYR A 1 253 ? 44.895 -10.414 -18.748 1.00 26.48  ? 247 TYR A OH  1 
ATOM 2050 N N   . CYS A 1 254 ? 40.552 -13.937 -13.837 1.00 24.51  ? 248 CYS A N   1 
ATOM 2051 C CA  . CYS A 1 254 ? 40.600 -13.300 -12.526 1.00 37.83  ? 248 CYS A CA  1 
ATOM 2052 C C   . CYS A 1 254 ? 41.162 -14.232 -11.465 1.00 30.85  ? 248 CYS A C   1 
ATOM 2053 O O   . CYS A 1 254 ? 41.935 -13.805 -10.603 1.00 22.35  ? 248 CYS A O   1 
ATOM 2054 C CB  . CYS A 1 254 ? 39.197 -12.838 -12.124 1.00 44.29  ? 248 CYS A CB  1 
ATOM 2055 S SG  . CYS A 1 254 ? 39.106 -12.100 -10.478 1.00 23.70  ? 248 CYS A SG  1 
ATOM 2056 N N   . ILE A 1 255 ? 40.779 -15.508 -11.500 1.00 40.55  ? 249 ILE A N   1 
ATOM 2057 C CA  . ILE A 1 255 ? 41.231 -16.424 -10.459 1.00 42.74  ? 249 ILE A CA  1 
ATOM 2058 C C   . ILE A 1 255 ? 42.693 -16.816 -10.658 1.00 34.34  ? 249 ILE A C   1 
ATOM 2059 O O   . ILE A 1 255 ? 43.412 -17.019 -9.677  1.00 43.61  ? 249 ILE A O   1 
ATOM 2060 C CB  . ILE A 1 255 ? 40.303 -17.650 -10.380 1.00 39.78  ? 249 ILE A CB  1 
ATOM 2061 C CG1 . ILE A 1 255 ? 38.880 -17.209 -10.016 1.00 63.98  ? 249 ILE A CG1 1 
ATOM 2062 C CG2 . ILE A 1 255 ? 40.796 -18.637 -9.337  1.00 56.04  ? 249 ILE A CG2 1 
ATOM 2063 C CD1 . ILE A 1 255 ? 38.746 -16.679 -8.596  1.00 68.64  ? 249 ILE A CD1 1 
ATOM 2064 N N   . VAL A 1 256 ? 43.172 -16.911 -11.902 1.00 28.43  ? 250 VAL A N   1 
ATOM 2065 C CA  . VAL A 1 256 ? 44.605 -17.099 -12.122 1.00 19.94  ? 250 VAL A CA  1 
ATOM 2066 C C   . VAL A 1 256 ? 45.379 -15.948 -11.498 1.00 28.60  ? 250 VAL A C   1 
ATOM 2067 O O   . VAL A 1 256 ? 46.349 -16.152 -10.749 1.00 46.44  ? 250 VAL A O   1 
ATOM 2068 C CB  . VAL A 1 256 ? 44.912 -17.227 -13.624 1.00 18.60  ? 250 VAL A CB  1 
ATOM 2069 C CG1 . VAL A 1 256 ? 46.406 -17.076 -13.865 1.00 18.64  ? 250 VAL A CG1 1 
ATOM 2070 C CG2 . VAL A 1 256 ? 44.421 -18.561 -14.159 1.00 21.12  ? 250 VAL A CG2 1 
ATOM 2071 N N   . ILE A 1 257 ? 44.946 -14.715 -11.782 1.00 31.04  ? 251 ILE A N   1 
ATOM 2072 C CA  . ILE A 1 257 ? 45.659 -13.560 -11.240 1.00 38.85  ? 251 ILE A CA  1 
ATOM 2073 C C   . ILE A 1 257 ? 45.561 -13.532 -9.715  1.00 37.40  ? 251 ILE A C   1 
ATOM 2074 O O   . ILE A 1 257 ? 46.520 -13.165 -9.024  1.00 34.08  ? 251 ILE A O   1 
ATOM 2075 C CB  . ILE A 1 257 ? 45.140 -12.256 -11.875 1.00 40.06  ? 251 ILE A CB  1 
ATOM 2076 C CG1 . ILE A 1 257 ? 45.352 -12.276 -13.388 1.00 40.95  ? 251 ILE A CG1 1 
ATOM 2077 C CG2 . ILE A 1 257 ? 45.858 -11.051 -11.300 1.00 32.17  ? 251 ILE A CG2 1 
ATOM 2078 C CD1 . ILE A 1 257 ? 44.651 -11.147 -14.108 1.00 49.80  ? 251 ILE A CD1 1 
ATOM 2079 N N   . ASN A 1 258 ? 44.414 -13.939 -9.164  1.00 40.78  ? 252 ASN A N   1 
ATOM 2080 C CA  . ASN A 1 258 ? 44.258 -13.977 -7.712  1.00 43.39  ? 252 ASN A CA  1 
ATOM 2081 C C   . ASN A 1 258 ? 45.202 -14.993 -7.082  1.00 35.91  ? 252 ASN A C   1 
ATOM 2082 O O   . ASN A 1 258 ? 45.886 -14.693 -6.097  1.00 45.83  ? 252 ASN A O   1 
ATOM 2083 C CB  . ASN A 1 258 ? 42.808 -14.298 -7.340  1.00 46.87  ? 252 ASN A CB  1 
ATOM 2084 C CG  . ASN A 1 258 ? 41.982 -13.053 -7.072  1.00 50.04  ? 252 ASN A CG  1 
ATOM 2085 O OD1 . ASN A 1 258 ? 42.010 -12.503 -5.975  1.00 34.41  ? 252 ASN A OD1 1 
ATOM 2086 N ND2 . ASN A 1 258 ? 41.238 -12.606 -8.077  1.00 79.63  ? 252 ASN A ND2 1 
ATOM 2087 N N   . ASP A 1 259 ? 45.238 -16.210 -7.627  1.00 26.67  ? 253 ASP A N   1 
ATOM 2088 C CA  . ASP A 1 259 ? 46.093 -17.255 -7.077  1.00 33.38  ? 253 ASP A CA  1 
ATOM 2089 C C   . ASP A 1 259 ? 47.566 -16.893 -7.188  1.00 37.51  ? 253 ASP A C   1 
ATOM 2090 O O   . ASP A 1 259 ? 48.376 -17.338 -6.367  1.00 40.07  ? 253 ASP A O   1 
ATOM 2091 C CB  . ASP A 1 259 ? 45.817 -18.582 -7.783  1.00 35.09  ? 253 ASP A CB  1 
ATOM 2092 C CG  . ASP A 1 259 ? 44.516 -19.217 -7.337  1.00 48.83  ? 253 ASP A CG  1 
ATOM 2093 O OD1 . ASP A 1 259 ? 43.742 -18.544 -6.621  1.00 54.86  ? 253 ASP A OD1 1 
ATOM 2094 O OD2 . ASP A 1 259 ? 44.266 -20.384 -7.709  1.00 49.73  ? 253 ASP A OD2 1 
ATOM 2095 N N   . LEU A 1 260 ? 47.937 -16.095 -8.192  1.00 41.36  ? 254 LEU A N   1 
ATOM 2096 C CA  . LEU A 1 260 ? 49.328 -15.666 -8.298  1.00 33.95  ? 254 LEU A CA  1 
ATOM 2097 C C   . LEU A 1 260 ? 49.655 -14.477 -7.395  1.00 44.08  ? 254 LEU A C   1 
ATOM 2098 O O   . LEU A 1 260 ? 50.798 -14.350 -6.943  1.00 52.84  ? 254 LEU A O   1 
ATOM 2099 C CB  . LEU A 1 260 ? 49.660 -15.364 -9.757  1.00 34.50  ? 254 LEU A CB  1 
ATOM 2100 C CG  . LEU A 1 260 ? 51.119 -15.084 -10.114 1.00 22.66  ? 254 LEU A CG  1 
ATOM 2101 C CD1 . LEU A 1 260 ? 52.087 -16.163 -9.730  1.00 34.91  ? 254 LEU A CD1 1 
ATOM 2102 C CD2 . LEU A 1 260 ? 51.165 -14.926 -11.610 1.00 49.83  ? 254 LEU A CD2 1 
ATOM 2103 N N   . TYR A 1 261 ? 48.681 -13.614 -7.096  1.00 52.86  ? 255 TYR A N   1 
ATOM 2104 C CA  . TYR A 1 261 ? 48.946 -12.517 -6.164  1.00 44.33  ? 255 TYR A CA  1 
ATOM 2105 C C   . TYR A 1 261 ? 48.961 -12.986 -4.710  1.00 35.23  ? 255 TYR A C   1 
ATOM 2106 O O   . TYR A 1 261 ? 49.779 -12.519 -3.908  1.00 46.45  ? 255 TYR A O   1 
ATOM 2107 C CB  . TYR A 1 261 ? 47.922 -11.398 -6.353  1.00 65.77  ? 255 TYR A CB  1 
ATOM 2108 C CG  . TYR A 1 261 ? 48.381 -10.285 -7.270  1.00 72.99  ? 255 TYR A CG  1 
ATOM 2109 C CD1 . TYR A 1 261 ? 48.571 -10.492 -8.631  1.00 46.63  ? 255 TYR A CD1 1 
ATOM 2110 C CD2 . TYR A 1 261 ? 48.609 -9.015  -6.765  1.00 82.30  ? 255 TYR A CD2 1 
ATOM 2111 C CE1 . TYR A 1 261 ? 48.992 -9.454  -9.453  1.00 42.03  ? 255 TYR A CE1 1 
ATOM 2112 C CE2 . TYR A 1 261 ? 49.023 -7.983  -7.570  1.00 67.10  ? 255 TYR A CE2 1 
ATOM 2113 C CZ  . TYR A 1 261 ? 49.214 -8.201  -8.907  1.00 48.78  ? 255 TYR A CZ  1 
ATOM 2114 O OH  . TYR A 1 261 ? 49.627 -7.150  -9.689  1.00 51.51  ? 255 TYR A OH  1 
ATOM 2115 N N   . SER A 1 262 ? 48.059 -13.894 -4.347  1.00 44.17  ? 256 SER A N   1 
ATOM 2116 C CA  . SER A 1 262 ? 47.923 -14.351 -2.969  1.00 50.55  ? 256 SER A CA  1 
ATOM 2117 C C   . SER A 1 262 ? 48.953 -15.399 -2.562  1.00 46.40  ? 256 SER A C   1 
ATOM 2118 O O   . SER A 1 262 ? 49.053 -15.709 -1.369  1.00 44.47  ? 256 SER A O   1 
ATOM 2119 C CB  . SER A 1 262 ? 46.518 -14.915 -2.747  1.00 46.32  ? 256 SER A CB  1 
ATOM 2120 O OG  . SER A 1 262 ? 46.305 -16.033 -3.588  1.00 57.19  ? 256 SER A OG  1 
ATOM 2121 N N   . TYR A 1 263 ? 49.703 -15.968 -3.507  1.00 52.51  ? 257 TYR A N   1 
ATOM 2122 C CA  . TYR A 1 263 ? 50.770 -16.886 -3.133  1.00 38.64  ? 257 TYR A CA  1 
ATOM 2123 C C   . TYR A 1 263 ? 52.035 -16.147 -2.710  1.00 44.96  ? 257 TYR A C   1 
ATOM 2124 O O   . TYR A 1 263 ? 52.917 -16.754 -2.091  1.00 57.30  ? 257 TYR A O   1 
ATOM 2125 C CB  . TYR A 1 263 ? 51.076 -17.843 -4.292  1.00 40.49  ? 257 TYR A CB  1 
ATOM 2126 C CG  . TYR A 1 263 ? 52.183 -18.842 -4.013  1.00 36.90  ? 257 TYR A CG  1 
ATOM 2127 C CD1 . TYR A 1 263 ? 52.039 -19.818 -3.038  1.00 37.14  ? 257 TYR A CD1 1 
ATOM 2128 C CD2 . TYR A 1 263 ? 53.381 -18.789 -4.707  1.00 52.90  ? 257 TYR A CD2 1 
ATOM 2129 C CE1 . TYR A 1 263 ? 53.051 -20.730 -2.781  1.00 42.74  ? 257 TYR A CE1 1 
ATOM 2130 C CE2 . TYR A 1 263 ? 54.399 -19.691 -4.453  1.00 51.19  ? 257 TYR A CE2 1 
ATOM 2131 C CZ  . TYR A 1 263 ? 54.231 -20.658 -3.491  1.00 43.55  ? 257 TYR A CZ  1 
ATOM 2132 O OH  . TYR A 1 263 ? 55.248 -21.552 -3.241  1.00 54.90  ? 257 TYR A OH  1 
ATOM 2133 N N   . GLN A 1 264 ? 52.131 -14.850 -3.014  1.00 43.40  ? 258 GLN A N   1 
ATOM 2134 C CA  . GLN A 1 264 ? 53.255 -14.014 -2.610  1.00 43.35  ? 258 GLN A CA  1 
ATOM 2135 C C   . GLN A 1 264 ? 52.934 -13.164 -1.384  1.00 53.20  ? 258 GLN A C   1 
ATOM 2136 O O   . GLN A 1 264 ? 53.542 -12.107 -1.189  1.00 71.05  ? 258 GLN A O   1 
ATOM 2137 C CB  . GLN A 1 264 ? 53.697 -13.124 -3.774  1.00 55.07  ? 258 GLN A CB  1 
ATOM 2138 C CG  . GLN A 1 264 ? 54.316 -13.872 -4.950  1.00 71.96  ? 258 GLN A CG  1 
ATOM 2139 C CD  . GLN A 1 264 ? 55.568 -14.636 -4.564  1.00 95.87  ? 258 GLN A CD  1 
ATOM 2140 O OE1 . GLN A 1 264 ? 56.630 -14.047 -4.364  1.00 88.47  ? 258 GLN A OE1 1 
ATOM 2141 N NE2 . GLN A 1 264 ? 55.449 -15.955 -4.455  1.00 117.59 ? 258 GLN A NE2 1 
ATOM 2142 N N   . ARG A 1 265 ? 51.995 -13.603 -0.551  1.00 65.39  ? 259 ARG A N   1 
ATOM 2143 C CA  . ARG A 1 265 ? 51.602 -12.876 0.646   1.00 56.82  ? 259 ARG A CA  1 
ATOM 2144 C C   . ARG A 1 265 ? 52.049 -13.620 1.899   1.00 63.88  ? 259 ARG A C   1 
ATOM 2145 O O   . ARG A 1 265 ? 52.346 -14.817 1.868   1.00 60.35  ? 259 ARG A O   1 
ATOM 2146 C CB  . ARG A 1 265 ? 50.085 -12.664 0.692   1.00 40.93  ? 259 ARG A CB  1 
ATOM 2147 C CG  . ARG A 1 265 ? 49.527 -11.863 -0.466  1.00 48.95  ? 259 ARG A CG  1 
ATOM 2148 C CD  . ARG A 1 265 ? 48.074 -11.504 -0.216  1.00 72.75  ? 259 ARG A CD  1 
ATOM 2149 N NE  . ARG A 1 265 ? 47.262 -12.674 0.101   1.00 92.10  ? 259 ARG A NE  1 
ATOM 2150 C CZ  . ARG A 1 265 ? 45.948 -12.642 0.285   1.00 99.19  ? 259 ARG A CZ  1 
ATOM 2151 N NH1 . ARG A 1 265 ? 45.262 -11.513 0.185   1.00 89.26  ? 259 ARG A NH1 1 
ATOM 2152 N NH2 . ARG A 1 265 ? 45.305 -13.772 0.570   1.00 91.70  ? 259 ARG A NH2 1 
ATOM 2153 N N   . ASP A 1 266 ? 52.093 -12.882 3.013   1.00 62.71  ? 260 ASP A N   1 
ATOM 2154 C CA  . ASP A 1 266 ? 52.372 -13.501 4.306   1.00 50.91  ? 260 ASP A CA  1 
ATOM 2155 C C   . ASP A 1 266 ? 51.273 -14.480 4.694   1.00 54.86  ? 260 ASP A C   1 
ATOM 2156 O O   . ASP A 1 266 ? 51.549 -15.548 5.253   1.00 65.00  ? 260 ASP A O   1 
ATOM 2157 C CB  . ASP A 1 266 ? 52.529 -12.428 5.385   1.00 54.58  ? 260 ASP A CB  1 
ATOM 2158 C CG  . ASP A 1 266 ? 53.723 -11.528 5.145   1.00 87.65  ? 260 ASP A CG  1 
ATOM 2159 O OD1 . ASP A 1 266 ? 54.575 -11.878 4.301   1.00 101.31 ? 260 ASP A OD1 1 
ATOM 2160 O OD2 . ASP A 1 266 ? 53.812 -10.468 5.800   1.00 90.47  ? 260 ASP A OD2 1 
ATOM 2161 N N   . LYS A 1 267 ? 50.021 -14.127 4.414   1.00 61.36  ? 261 LYS A N   1 
ATOM 2162 C CA  . LYS A 1 267 ? 48.901 -15.015 4.693   1.00 56.81  ? 261 LYS A CA  1 
ATOM 2163 C C   . LYS A 1 267 ? 49.029 -16.300 3.882   1.00 52.57  ? 261 LYS A C   1 
ATOM 2164 O O   . LYS A 1 267 ? 49.186 -16.257 2.659   1.00 58.59  ? 261 LYS A O   1 
ATOM 2165 C CB  . LYS A 1 267 ? 47.586 -14.304 4.374   1.00 49.82  ? 261 LYS A CB  1 
ATOM 2166 C CG  . LYS A 1 267 ? 46.353 -15.155 4.606   1.00 66.02  ? 261 LYS A CG  1 
ATOM 2167 C CD  . LYS A 1 267 ? 45.083 -14.339 4.434   1.00 89.00  ? 261 LYS A CD  1 
ATOM 2168 C CE  . LYS A 1 267 ? 43.846 -15.183 4.712   1.00 85.54  ? 261 LYS A CE  1 
ATOM 2169 N NZ  . LYS A 1 267 ? 42.581 -14.408 4.570   1.00 106.44 ? 261 LYS A NZ  1 
ATOM 2170 N N   . LEU A 1 268 ? 48.988 -17.439 4.572   1.00 42.08  ? 262 LEU A N   1 
ATOM 2171 C CA  . LEU A 1 268 ? 48.978 -18.737 3.910   1.00 55.64  ? 262 LEU A CA  1 
ATOM 2172 C C   . LEU A 1 268 ? 47.858 -18.809 2.883   1.00 75.94  ? 262 LEU A C   1 
ATOM 2173 O O   . LEU A 1 268 ? 46.704 -18.491 3.181   1.00 68.87  ? 262 LEU A O   1 
ATOM 2174 C CB  . LEU A 1 268 ? 48.806 -19.841 4.950   1.00 61.92  ? 262 LEU A CB  1 
ATOM 2175 C CG  . LEU A 1 268 ? 48.701 -21.282 4.461   1.00 34.14  ? 262 LEU A CG  1 
ATOM 2176 C CD1 . LEU A 1 268 ? 49.897 -21.683 3.653   1.00 28.80  ? 262 LEU A CD1 1 
ATOM 2177 C CD2 . LEU A 1 268 ? 48.565 -22.182 5.648   1.00 82.65  ? 262 LEU A CD2 1 
ATOM 2178 N N   . ALA A 1 269 ? 48.207 -19.225 1.665   1.00 70.68  ? 263 ALA A N   1 
ATOM 2179 C CA  . ALA A 1 269 ? 47.205 -19.318 0.608   1.00 60.19  ? 263 ALA A CA  1 
ATOM 2180 C C   . ALA A 1 269 ? 46.148 -20.359 0.946   1.00 72.63  ? 263 ALA A C   1 
ATOM 2181 O O   . ALA A 1 269 ? 44.956 -20.151 0.691   1.00 82.36  ? 263 ALA A O   1 
ATOM 2182 C CB  . ALA A 1 269 ? 47.876 -19.653 -0.720  1.00 71.29  ? 263 ALA A CB  1 
ATOM 2183 N N   . SER A 1 270 ? 46.565 -21.468 1.538   1.00 80.66  ? 264 SER A N   1 
ATOM 2184 C CA  . SER A 1 270 ? 45.678 -22.578 1.938   1.00 87.67  ? 264 SER A CA  1 
ATOM 2185 C C   . SER A 1 270 ? 44.889 -22.997 0.691   1.00 89.07  ? 264 SER A C   1 
ATOM 2186 O O   . SER A 1 270 ? 45.440 -22.958 -0.419  1.00 93.62  ? 264 SER A O   1 
ATOM 2187 C CB  . SER A 1 270 ? 44.831 -22.156 3.142   1.00 89.56  ? 264 SER A CB  1 
ATOM 2188 O OG  . SER A 1 270 ? 44.174 -23.258 3.748   1.00 95.63  ? 264 SER A OG  1 
ATOM 2189 N N   . SER A 1 271 ? 43.620 -23.394 0.829   1.00 73.91  ? 265 SER A N   1 
ATOM 2190 C CA  . SER A 1 271 ? 42.750 -23.611 -0.330  1.00 88.83  ? 265 SER A CA  1 
ATOM 2191 C C   . SER A 1 271 ? 43.300 -24.572 -1.380  1.00 75.08  ? 265 SER A C   1 
ATOM 2192 O O   . SER A 1 271 ? 44.116 -25.447 -1.078  1.00 45.30  ? 265 SER A O   1 
ATOM 2193 C CB  . SER A 1 271 ? 42.453 -22.286 -1.030  1.00 92.67  ? 265 SER A CB  1 
ATOM 2194 O OG  . SER A 1 271 ? 41.344 -22.422 -1.906  1.00 105.57 ? 265 SER A OG  1 
ATOM 2195 N N   . ASP A 1 272 ? 42.851 -24.415 -2.625  1.00 75.80  ? 266 ASP A N   1 
ATOM 2196 C CA  . ASP A 1 272 ? 43.371 -25.192 -3.742  1.00 74.13  ? 266 ASP A CA  1 
ATOM 2197 C C   . ASP A 1 272 ? 44.125 -24.272 -4.701  1.00 64.20  ? 266 ASP A C   1 
ATOM 2198 O O   . ASP A 1 272 ? 43.920 -24.292 -5.917  1.00 54.66  ? 266 ASP A O   1 
ATOM 2199 C CB  . ASP A 1 272 ? 42.249 -25.951 -4.446  1.00 89.02  ? 266 ASP A CB  1 
ATOM 2200 C CG  . ASP A 1 272 ? 42.772 -26.895 -5.490  1.00 89.64  ? 266 ASP A CG  1 
ATOM 2201 O OD1 . ASP A 1 272 ? 44.002 -27.123 -5.469  1.00 89.11  ? 266 ASP A OD1 1 
ATOM 2202 O OD2 . ASP A 1 272 ? 41.977 -27.416 -6.304  1.00 74.30  ? 266 ASP A OD2 1 
ATOM 2203 N N   . ASN A 1 273 ? 44.988 -23.430 -4.138  1.00 60.61  ? 267 ASN A N   1 
ATOM 2204 C CA  . ASN A 1 273 ? 45.775 -22.488 -4.924  1.00 46.42  ? 267 ASN A CA  1 
ATOM 2205 C C   . ASN A 1 273 ? 46.579 -23.234 -5.975  1.00 54.56  ? 267 ASN A C   1 
ATOM 2206 O O   . ASN A 1 273 ? 47.322 -24.164 -5.652  1.00 55.03  ? 267 ASN A O   1 
ATOM 2207 C CB  . ASN A 1 273 ? 46.696 -21.692 -3.995  1.00 36.93  ? 267 ASN A CB  1 
ATOM 2208 C CG  . ASN A 1 273 ? 47.532 -20.664 -4.735  1.00 45.36  ? 267 ASN A CG  1 
ATOM 2209 O OD1 . ASN A 1 273 ? 48.583 -20.983 -5.293  1.00 59.88  ? 267 ASN A OD1 1 
ATOM 2210 N ND2 . ASN A 1 273 ? 47.072 -19.419 -4.735  1.00 50.25  ? 267 ASN A ND2 1 
ATOM 2211 N N   . MET A 1 274 ? 46.427 -22.823 -7.238  1.00 50.54  ? 268 MET A N   1 
ATOM 2212 C CA  . MET A 1 274 ? 46.954 -23.616 -8.346  1.00 44.95  ? 268 MET A CA  1 
ATOM 2213 C C   . MET A 1 274 ? 48.478 -23.682 -8.322  1.00 51.22  ? 268 MET A C   1 
ATOM 2214 O O   . MET A 1 274 ? 49.064 -24.704 -8.702  1.00 60.05  ? 268 MET A O   1 
ATOM 2215 C CB  . MET A 1 274 ? 46.453 -23.057 -9.680  1.00 47.68  ? 268 MET A CB  1 
ATOM 2216 C CG  . MET A 1 274 ? 46.818 -21.610 -9.969  1.00 66.93  ? 268 MET A CG  1 
ATOM 2217 S SD  . MET A 1 274 ? 46.112 -21.035 -11.529 1.00 51.17  ? 268 MET A SD  1 
ATOM 2218 C CE  . MET A 1 274 ? 44.375 -20.922 -11.105 1.00 46.41  ? 268 MET A CE  1 
ATOM 2219 N N   . ILE A 1 275 ? 49.135 -22.608 -7.881  1.00 44.51  ? 269 ILE A N   1 
ATOM 2220 C CA  . ILE A 1 275 ? 50.594 -22.601 -7.803  1.00 36.85  ? 269 ILE A CA  1 
ATOM 2221 C C   . ILE A 1 275 ? 51.071 -23.647 -6.811  1.00 39.73  ? 269 ILE A C   1 
ATOM 2222 O O   . ILE A 1 275 ? 52.082 -24.322 -7.032  1.00 37.24  ? 269 ILE A O   1 
ATOM 2223 C CB  . ILE A 1 275 ? 51.094 -21.207 -7.404  1.00 22.36  ? 269 ILE A CB  1 
ATOM 2224 C CG1 . ILE A 1 275 ? 50.495 -20.159 -8.321  1.00 31.47  ? 269 ILE A CG1 1 
ATOM 2225 C CG2 . ILE A 1 275 ? 52.611 -21.155 -7.474  1.00 20.53  ? 269 ILE A CG2 1 
ATOM 2226 C CD1 . ILE A 1 275 ? 50.983 -18.817 -7.993  1.00 28.15  ? 269 ILE A CD1 1 
ATOM 2227 N N   . LYS A 1 276 ? 50.370 -23.765 -5.684  1.00 47.94  ? 270 LYS A N   1 
ATOM 2228 C CA  . LYS A 1 276 ? 50.680 -24.799 -4.706  1.00 47.52  ? 270 LYS A CA  1 
ATOM 2229 C C   . LYS A 1 276 ? 50.584 -26.184 -5.333  1.00 55.20  ? 270 LYS A C   1 
ATOM 2230 O O   . LYS A 1 276 ? 51.484 -27.016 -5.166  1.00 62.72  ? 270 LYS A O   1 
ATOM 2231 C CB  . LYS A 1 276 ? 49.723 -24.666 -3.523  1.00 38.07  ? 270 LYS A CB  1 
ATOM 2232 C CG  . LYS A 1 276 ? 49.981 -23.436 -2.670  1.00 42.45  ? 270 LYS A CG  1 
ATOM 2233 C CD  . LYS A 1 276 ? 49.021 -23.369 -1.498  1.00 76.54  ? 270 LYS A CD  1 
ATOM 2234 C CE  . LYS A 1 276 ? 49.098 -24.626 -0.658  1.00 80.14  ? 270 LYS A CE  1 
ATOM 2235 N NZ  . LYS A 1 276 ? 48.167 -24.581 0.501   1.00 65.13  ? 270 LYS A NZ  1 
ATOM 2236 N N   . THR A 1 277 ? 49.503 -26.437 -6.077  1.00 42.65  ? 271 THR A N   1 
ATOM 2237 C CA  . THR A 1 277 ? 49.305 -27.740 -6.705  1.00 37.17  ? 271 THR A CA  1 
ATOM 2238 C C   . THR A 1 277 ? 50.410 -28.042 -7.710  1.00 52.07  ? 271 THR A C   1 
ATOM 2239 O O   . THR A 1 277 ? 50.939 -29.158 -7.748  1.00 67.27  ? 271 THR A O   1 
ATOM 2240 C CB  . THR A 1 277 ? 47.932 -27.797 -7.381  1.00 39.85  ? 271 THR A CB  1 
ATOM 2241 O OG1 . THR A 1 277 ? 46.920 -27.419 -6.440  1.00 54.66  ? 271 THR A OG1 1 
ATOM 2242 C CG2 . THR A 1 277 ? 47.648 -29.200 -7.877  1.00 42.26  ? 271 THR A CG2 1 
ATOM 2243 N N   . TRP A 1 278 ? 50.774 -27.054 -8.534  1.00 51.14  ? 272 TRP A N   1 
ATOM 2244 C CA  . TRP A 1 278 ? 51.862 -27.254 -9.489  1.00 57.14  ? 272 TRP A CA  1 
ATOM 2245 C C   . TRP A 1 278 ? 53.175 -27.535 -8.772  1.00 58.19  ? 272 TRP A C   1 
ATOM 2246 O O   . TRP A 1 278 ? 53.860 -28.520 -9.069  1.00 69.26  ? 272 TRP A O   1 
ATOM 2247 C CB  . TRP A 1 278 ? 52.016 -26.037 -10.405 1.00 51.59  ? 272 TRP A CB  1 
ATOM 2248 C CG  . TRP A 1 278 ? 50.785 -25.634 -11.160 1.00 53.32  ? 272 TRP A CG  1 
ATOM 2249 C CD1 . TRP A 1 278 ? 49.712 -26.420 -11.474 1.00 56.44  ? 272 TRP A CD1 1 
ATOM 2250 C CD2 . TRP A 1 278 ? 50.523 -24.349 -11.735 1.00 49.46  ? 272 TRP A CD2 1 
ATOM 2251 N NE1 . TRP A 1 278 ? 48.790 -25.694 -12.192 1.00 40.34  ? 272 TRP A NE1 1 
ATOM 2252 C CE2 . TRP A 1 278 ? 49.264 -24.420 -12.366 1.00 47.12  ? 272 TRP A CE2 1 
ATOM 2253 C CE3 . TRP A 1 278 ? 51.227 -23.142 -11.767 1.00 46.47  ? 272 TRP A CE3 1 
ATOM 2254 C CZ2 . TRP A 1 278 ? 48.696 -23.327 -13.022 1.00 42.83  ? 272 TRP A CZ2 1 
ATOM 2255 C CZ3 . TRP A 1 278 ? 50.663 -22.060 -12.418 1.00 41.47  ? 272 TRP A CZ3 1 
ATOM 2256 C CH2 . TRP A 1 278 ? 49.411 -22.159 -13.037 1.00 32.70  ? 272 TRP A CH2 1 
ATOM 2257 N N   . LEU A 1 279 ? 53.540 -26.675 -7.819  1.00 49.84  ? 273 LEU A N   1 
ATOM 2258 C CA  . LEU A 1 279 ? 54.824 -26.785 -7.143  1.00 46.27  ? 273 LEU A CA  1 
ATOM 2259 C C   . LEU A 1 279 ? 54.933 -28.059 -6.318  1.00 42.45  ? 273 LEU A C   1 
ATOM 2260 O O   . LEU A 1 279 ? 56.049 -28.521 -6.060  1.00 49.49  ? 273 LEU A O   1 
ATOM 2261 C CB  . LEU A 1 279 ? 55.040 -25.554 -6.264  1.00 34.62  ? 273 LEU A CB  1 
ATOM 2262 C CG  . LEU A 1 279 ? 56.380 -25.388 -5.554  1.00 69.16  ? 273 LEU A CG  1 
ATOM 2263 C CD1 . LEU A 1 279 ? 57.512 -25.372 -6.569  1.00 70.90  ? 273 LEU A CD1 1 
ATOM 2264 C CD2 . LEU A 1 279 ? 56.369 -24.114 -4.742  1.00 67.56  ? 273 LEU A CD2 1 
ATOM 2265 N N   . LEU A 1 280 ? 53.803 -28.639 -5.903  1.00 47.72  ? 274 LEU A N   1 
ATOM 2266 C CA  . LEU A 1 280 ? 53.852 -29.941 -5.247  1.00 72.22  ? 274 LEU A CA  1 
ATOM 2267 C C   . LEU A 1 280 ? 54.438 -31.007 -6.163  1.00 77.96  ? 274 LEU A C   1 
ATOM 2268 O O   . LEU A 1 280 ? 55.095 -31.941 -5.688  1.00 96.09  ? 274 LEU A O   1 
ATOM 2269 C CB  . LEU A 1 280 ? 52.451 -30.355 -4.790  1.00 76.15  ? 274 LEU A CB  1 
ATOM 2270 C CG  . LEU A 1 280 ? 52.325 -31.677 -4.024  1.00 83.64  ? 274 LEU A CG  1 
ATOM 2271 C CD1 . LEU A 1 280 ? 53.132 -31.655 -2.735  1.00 66.31  ? 274 LEU A CD1 1 
ATOM 2272 C CD2 . LEU A 1 280 ? 50.865 -31.995 -3.738  1.00 76.11  ? 274 LEU A CD2 1 
ATOM 2273 N N   . GLU A 1 281 ? 54.239 -30.872 -7.474  1.00 79.50  ? 275 GLU A N   1 
ATOM 2274 C CA  . GLU A 1 281 ? 54.515 -31.971 -8.388  1.00 82.96  ? 275 GLU A CA  1 
ATOM 2275 C C   . GLU A 1 281 ? 55.318 -31.548 -9.614  1.00 68.64  ? 275 GLU A C   1 
ATOM 2276 O O   . GLU A 1 281 ? 56.319 -32.183 -9.958  1.00 71.22  ? 275 GLU A O   1 
ATOM 2277 C CB  . GLU A 1 281 ? 53.196 -32.593 -8.845  1.00 88.56  ? 275 GLU A CB  1 
ATOM 2278 C CG  . GLU A 1 281 ? 52.366 -33.206 -7.730  1.00 100.26 ? 275 GLU A CG  1 
ATOM 2279 C CD  . GLU A 1 281 ? 51.062 -33.771 -8.244  1.00 118.76 ? 275 GLU A CD  1 
ATOM 2280 O OE1 . GLU A 1 281 ? 50.816 -33.654 -9.463  1.00 121.61 ? 275 GLU A OE1 1 
ATOM 2281 O OE2 . GLU A 1 281 ? 50.285 -34.326 -7.438  1.00 119.47 ? 275 GLU A OE2 1 
ATOM 2282 N N   . LYS A 1 282 ? 54.888 -30.479 -10.279 1.00 67.40  ? 276 LYS A N   1 
ATOM 2283 C CA  . LYS A 1 282 ? 55.210 -30.252 -11.684 1.00 70.03  ? 276 LYS A CA  1 
ATOM 2284 C C   . LYS A 1 282 ? 55.795 -28.864 -11.920 1.00 56.74  ? 276 LYS A C   1 
ATOM 2285 O O   . LYS A 1 282 ? 55.499 -28.207 -12.923 1.00 42.98  ? 276 LYS A O   1 
ATOM 2286 C CB  . LYS A 1 282 ? 53.966 -30.479 -12.539 1.00 67.09  ? 276 LYS A CB  1 
ATOM 2287 C CG  . LYS A 1 282 ? 52.765 -29.661 -12.067 1.00 72.33  ? 276 LYS A CG  1 
ATOM 2288 C CD  . LYS A 1 282 ? 51.439 -30.185 -12.611 1.00 84.87  ? 276 LYS A CD  1 
ATOM 2289 C CE  . LYS A 1 282 ? 51.383 -30.151 -14.122 1.00 82.80  ? 276 LYS A CE  1 
ATOM 2290 N NZ  . LYS A 1 282 ? 50.082 -30.675 -14.622 1.00 95.70  ? 276 LYS A NZ  1 
ATOM 2291 N N   . THR A 1 283 ? 56.652 -28.400 -11.014 1.00 72.32  ? 277 THR A N   1 
ATOM 2292 C CA  . THR A 1 283 ? 57.345 -27.132 -11.205 1.00 85.37  ? 277 THR A CA  1 
ATOM 2293 C C   . THR A 1 283 ? 58.735 -27.232 -10.593 1.00 98.05  ? 277 THR A C   1 
ATOM 2294 O O   . THR A 1 283 ? 58.939 -27.902 -9.572  1.00 107.44 ? 277 THR A O   1 
ATOM 2295 C CB  . THR A 1 283 ? 56.564 -25.956 -10.603 1.00 77.72  ? 277 THR A CB  1 
ATOM 2296 O OG1 . THR A 1 283 ? 55.207 -26.000 -11.058 1.00 70.02  ? 277 THR A OG1 1 
ATOM 2297 C CG2 . THR A 1 283 ? 57.181 -24.625 -11.017 1.00 57.92  ? 277 THR A CG2 1 
ATOM 2298 N N   . VAL A 1 284 ? 59.692 -26.565 -11.243 1.00 84.32  ? 278 VAL A N   1 
ATOM 2299 C CA  . VAL A 1 284 ? 61.108 -26.730 -10.937 1.00 91.77  ? 278 VAL A CA  1 
ATOM 2300 C C   . VAL A 1 284 ? 61.470 -25.657 -9.931  1.00 85.22  ? 278 VAL A C   1 
ATOM 2301 O O   . VAL A 1 284 ? 61.371 -25.863 -8.718  1.00 59.52  ? 278 VAL A O   1 
ATOM 2302 C CB  . VAL A 1 284 ? 61.974 -26.578 -12.197 1.00 86.28  ? 278 VAL A CB  1 
ATOM 2303 C CG1 . VAL A 1 284 ? 63.448 -26.859 -11.929 1.00 87.35  ? 278 VAL A CG1 1 
ATOM 2304 C CG2 . VAL A 1 284 ? 61.393 -27.345 -13.349 1.00 76.02  ? 278 VAL A CG2 1 
ATOM 2305 N N   . SER A 1 285 ? 61.895 -24.505 -10.441 1.00 99.95  ? 279 SER A N   1 
ATOM 2306 C CA  . SER A 1 285 ? 61.971 -23.276 -9.667  1.00 89.62  ? 279 SER A CA  1 
ATOM 2307 C C   . SER A 1 285 ? 60.578 -22.659 -9.618  1.00 60.50  ? 279 SER A C   1 
ATOM 2308 O O   . SER A 1 285 ? 59.868 -22.644 -10.629 1.00 81.95  ? 279 SER A O   1 
ATOM 2309 C CB  . SER A 1 285 ? 62.992 -22.318 -10.290 1.00 94.67  ? 279 SER A CB  1 
ATOM 2310 O OG  . SER A 1 285 ? 62.669 -22.005 -11.637 1.00 125.49 ? 279 SER A OG  1 
ATOM 2311 N N   . SER A 1 286 ? 60.188 -22.165 -8.442  1.00 38.49  ? 280 SER A N   1 
ATOM 2312 C CA  . SER A 1 286 ? 58.796 -21.837 -8.164  1.00 69.27  ? 280 SER A CA  1 
ATOM 2313 C C   . SER A 1 286 ? 58.302 -20.654 -8.985  1.00 54.35  ? 280 SER A C   1 
ATOM 2314 O O   . SER A 1 286 ? 57.600 -20.824 -9.990  1.00 59.41  ? 280 SER A O   1 
ATOM 2315 C CB  . SER A 1 286 ? 58.621 -21.535 -6.671  1.00 98.19  ? 280 SER A CB  1 
ATOM 2316 O OG  . SER A 1 286 ? 57.266 -21.286 -6.342  1.00 89.45  ? 280 SER A OG  1 
ATOM 2317 N N   . LEU A 1 287 ? 58.667 -19.450 -8.542  1.00 57.15  ? 281 LEU A N   1 
ATOM 2318 C CA  . LEU A 1 287 ? 57.989 -18.242 -8.996  1.00 69.30  ? 281 LEU A CA  1 
ATOM 2319 C C   . LEU A 1 287 ? 58.201 -17.999 -10.485 1.00 68.15  ? 281 LEU A C   1 
ATOM 2320 O O   . LEU A 1 287 ? 57.249 -17.679 -11.205 1.00 68.82  ? 281 LEU A O   1 
ATOM 2321 C CB  . LEU A 1 287 ? 58.472 -17.044 -8.180  1.00 84.52  ? 281 LEU A CB  1 
ATOM 2322 C CG  . LEU A 1 287 ? 57.777 -15.710 -8.437  1.00 111.64 ? 281 LEU A CG  1 
ATOM 2323 C CD1 . LEU A 1 287 ? 56.283 -15.831 -8.173  1.00 98.02  ? 281 LEU A CD1 1 
ATOM 2324 C CD2 . LEU A 1 287 ? 58.392 -14.606 -7.588  1.00 120.84 ? 281 LEU A CD2 1 
ATOM 2325 N N   . SER A 1 288 ? 59.436 -18.159 -10.967 1.00 59.81  ? 282 SER A N   1 
ATOM 2326 C CA  . SER A 1 288 ? 59.736 -17.804 -12.351 1.00 74.18  ? 282 SER A CA  1 
ATOM 2327 C C   . SER A 1 288 ? 58.958 -18.666 -13.337 1.00 76.34  ? 282 SER A C   1 
ATOM 2328 O O   . SER A 1 288 ? 58.546 -18.178 -14.395 1.00 84.39  ? 282 SER A O   1 
ATOM 2329 C CB  . SER A 1 288 ? 61.240 -17.917 -12.618 1.00 96.50  ? 282 SER A CB  1 
ATOM 2330 O OG  . SER A 1 288 ? 61.758 -19.150 -12.151 1.00 93.39  ? 282 SER A OG  1 
ATOM 2331 N N   . GLU A 1 289 ? 58.743 -19.938 -13.010 1.00 65.80  ? 283 GLU A N   1 
ATOM 2332 C CA  . GLU A 1 289 ? 58.019 -20.835 -13.902 1.00 64.31  ? 283 GLU A CA  1 
ATOM 2333 C C   . GLU A 1 289 ? 56.509 -20.773 -13.695 1.00 60.82  ? 283 GLU A C   1 
ATOM 2334 O O   . GLU A 1 289 ? 55.747 -20.866 -14.666 1.00 56.13  ? 283 GLU A O   1 
ATOM 2335 C CB  . GLU A 1 289 ? 58.516 -22.267 -13.713 1.00 64.16  ? 283 GLU A CB  1 
ATOM 2336 C CG  . GLU A 1 289 ? 59.957 -22.455 -14.119 1.00 63.15  ? 283 GLU A CG  1 
ATOM 2337 C CD  . GLU A 1 289 ? 60.463 -23.838 -13.806 1.00 65.42  ? 283 GLU A CD  1 
ATOM 2338 O OE1 . GLU A 1 289 ? 59.645 -24.689 -13.398 1.00 87.72  ? 283 GLU A OE1 1 
ATOM 2339 O OE2 . GLU A 1 289 ? 61.676 -24.072 -13.981 1.00 47.84  ? 283 GLU A OE2 1 
ATOM 2340 N N   . ALA A 1 290 ? 56.059 -20.624 -12.446 1.00 56.38  ? 284 ALA A N   1 
ATOM 2341 C CA  . ALA A 1 290 ? 54.630 -20.460 -12.197 1.00 52.06  ? 284 ALA A CA  1 
ATOM 2342 C C   . ALA A 1 290 ? 54.109 -19.192 -12.855 1.00 54.02  ? 284 ALA A C   1 
ATOM 2343 O O   . ALA A 1 290 ? 52.996 -19.168 -13.397 1.00 47.81  ? 284 ALA A O   1 
ATOM 2344 C CB  . ALA A 1 290 ? 54.360 -20.438 -10.694 1.00 22.58  ? 284 ALA A CB  1 
ATOM 2345 N N   . THR A 1 291 ? 54.924 -18.136 -12.855 1.00 49.01  ? 285 THR A N   1 
ATOM 2346 C CA  . THR A 1 291 ? 54.518 -16.888 -13.482 1.00 44.44  ? 285 THR A CA  1 
ATOM 2347 C C   . THR A 1 291 ? 54.400 -17.046 -14.992 1.00 48.58  ? 285 THR A C   1 
ATOM 2348 O O   . THR A 1 291 ? 53.479 -16.504 -15.605 1.00 63.26  ? 285 THR A O   1 
ATOM 2349 C CB  . THR A 1 291 ? 55.515 -15.786 -13.129 1.00 45.74  ? 285 THR A CB  1 
ATOM 2350 O OG1 . THR A 1 291 ? 55.545 -15.610 -11.707 1.00 39.35  ? 285 THR A OG1 1 
ATOM 2351 C CG2 . THR A 1 291 ? 55.111 -14.479 -13.778 1.00 65.18  ? 285 THR A CG2 1 
ATOM 2352 N N   . ALA A 1 292 ? 55.310 -17.801 -15.609 1.00 37.82  ? 286 ALA A N   1 
ATOM 2353 C CA  . ALA A 1 292 ? 55.232 -17.990 -17.055 1.00 36.62  ? 286 ALA A CA  1 
ATOM 2354 C C   . ALA A 1 292 ? 54.049 -18.874 -17.434 1.00 44.75  ? 286 ALA A C   1 
ATOM 2355 O O   . ALA A 1 292 ? 53.395 -18.639 -18.457 1.00 60.82  ? 286 ALA A O   1 
ATOM 2356 C CB  . ALA A 1 292 ? 56.540 -18.576 -17.584 1.00 51.22  ? 286 ALA A CB  1 
ATOM 2357 N N   . ARG A 1 293 ? 53.754 -19.894 -16.625 1.00 40.64  ? 287 ARG A N   1 
ATOM 2358 C CA  . ARG A 1 293 ? 52.558 -20.696 -16.871 1.00 36.93  ? 287 ARG A CA  1 
ATOM 2359 C C   . ARG A 1 293 ? 51.305 -19.832 -16.785 1.00 25.82  ? 287 ARG A C   1 
ATOM 2360 O O   . ARG A 1 293 ? 50.425 -19.894 -17.656 1.00 25.51  ? 287 ARG A O   1 
ATOM 2361 C CB  . ARG A 1 293 ? 52.488 -21.858 -15.877 1.00 56.03  ? 287 ARG A CB  1 
ATOM 2362 C CG  . ARG A 1 293 ? 53.510 -22.942 -16.155 1.00 62.10  ? 287 ARG A CG  1 
ATOM 2363 C CD  . ARG A 1 293 ? 53.685 -23.911 -14.996 1.00 72.83  ? 287 ARG A CD  1 
ATOM 2364 N NE  . ARG A 1 293 ? 52.464 -24.632 -14.659 1.00 82.68  ? 287 ARG A NE  1 
ATOM 2365 C CZ  . ARG A 1 293 ? 52.028 -25.700 -15.314 1.00 79.23  ? 287 ARG A CZ  1 
ATOM 2366 N NH1 . ARG A 1 293 ? 52.687 -26.194 -16.349 1.00 82.03  ? 287 ARG A NH1 1 
ATOM 2367 N NH2 . ARG A 1 293 ? 50.908 -26.294 -14.913 1.00 83.35  ? 287 ARG A NH2 1 
ATOM 2368 N N   . CYS A 1 294 ? 51.216 -19.002 -15.742 1.00 39.37  ? 288 CYS A N   1 
ATOM 2369 C CA  . CYS A 1 294 ? 50.074 -18.106 -15.601 1.00 36.22  ? 288 CYS A CA  1 
ATOM 2370 C C   . CYS A 1 294 ? 49.992 -17.123 -16.762 1.00 28.40  ? 288 CYS A C   1 
ATOM 2371 O O   . CYS A 1 294 ? 48.899 -16.818 -17.245 1.00 31.74  ? 288 CYS A O   1 
ATOM 2372 C CB  . CYS A 1 294 ? 50.155 -17.356 -14.270 1.00 41.69  ? 288 CYS A CB  1 
ATOM 2373 S SG  . CYS A 1 294 ? 49.931 -18.398 -12.803 1.00 48.08  ? 288 CYS A SG  1 
ATOM 2374 N N   . SER A 1 295 ? 51.137 -16.612 -17.218 1.00 28.93  ? 289 SER A N   1 
ATOM 2375 C CA  . SER A 1 295 ? 51.142 -15.679 -18.339 1.00 29.66  ? 289 SER A CA  1 
ATOM 2376 C C   . SER A 1 295 ? 50.642 -16.351 -19.607 1.00 32.61  ? 289 SER A C   1 
ATOM 2377 O O   . SER A 1 295 ? 49.871 -15.757 -20.369 1.00 34.53  ? 289 SER A O   1 
ATOM 2378 C CB  . SER A 1 295 ? 52.549 -15.118 -18.549 1.00 28.27  ? 289 SER A CB  1 
ATOM 2379 O OG  . SER A 1 295 ? 52.962 -14.339 -17.439 1.00 43.87  ? 289 SER A OG  1 
ATOM 2380 N N   . GLN A 1 296 ? 51.078 -17.589 -19.853 1.00 28.60  ? 290 GLN A N   1 
ATOM 2381 C CA  . GLN A 1 296 ? 50.579 -18.333 -21.004 1.00 27.96  ? 290 GLN A CA  1 
ATOM 2382 C C   . GLN A 1 296 ? 49.071 -18.515 -20.924 1.00 29.45  ? 290 GLN A C   1 
ATOM 2383 O O   . GLN A 1 296 ? 48.361 -18.299 -21.913 1.00 38.93  ? 290 GLN A O   1 
ATOM 2384 C CB  . GLN A 1 296 ? 51.271 -19.694 -21.110 1.00 42.97  ? 290 GLN A CB  1 
ATOM 2385 C CG  . GLN A 1 296 ? 52.723 -19.629 -21.547 1.00 48.79  ? 290 GLN A CG  1 
ATOM 2386 C CD  . GLN A 1 296 ? 53.360 -21.000 -21.659 1.00 63.84  ? 290 GLN A CD  1 
ATOM 2387 O OE1 . GLN A 1 296 ? 52.688 -22.024 -21.535 1.00 62.50  ? 290 GLN A OE1 1 
ATOM 2388 N NE2 . GLN A 1 296 ? 54.666 -21.025 -21.896 1.00 77.76  ? 290 GLN A NE2 1 
ATOM 2389 N N   . ILE A 1 297 ? 48.562 -18.907 -19.750 1.00 22.23  ? 291 ILE A N   1 
ATOM 2390 C CA  . ILE A 1 297 ? 47.122 -19.126 -19.605 1.00 19.46  ? 291 ILE A CA  1 
ATOM 2391 C C   . ILE A 1 297 ? 46.350 -17.829 -19.830 1.00 23.96  ? 291 ILE A C   1 
ATOM 2392 O O   . ILE A 1 297 ? 45.315 -17.814 -20.510 1.00 26.15  ? 291 ILE A O   1 
ATOM 2393 C CB  . ILE A 1 297 ? 46.804 -19.744 -18.230 1.00 16.26  ? 291 ILE A CB  1 
ATOM 2394 C CG1 . ILE A 1 297 ? 47.381 -21.157 -18.137 1.00 21.42  ? 291 ILE A CG1 1 
ATOM 2395 C CG2 . ILE A 1 297 ? 45.300 -19.774 -17.997 1.00 21.77  ? 291 ILE A CG2 1 
ATOM 2396 C CD1 . ILE A 1 297 ? 47.461 -21.694 -16.733 1.00 27.25  ? 291 ILE A CD1 1 
ATOM 2397 N N   . LEU A 1 298 ? 46.845 -16.720 -19.275 1.00 23.92  ? 292 LEU A N   1 
ATOM 2398 C CA  . LEU A 1 298 ? 46.151 -15.443 -19.421 1.00 20.11  ? 292 LEU A CA  1 
ATOM 2399 C C   . LEU A 1 298 ? 46.152 -14.980 -20.872 1.00 23.56  ? 292 LEU A C   1 
ATOM 2400 O O   . LEU A 1 298 ? 45.124 -14.519 -21.390 1.00 26.28  ? 292 LEU A O   1 
ATOM 2401 C CB  . LEU A 1 298 ? 46.804 -14.390 -18.525 1.00 20.75  ? 292 LEU A CB  1 
ATOM 2402 C CG  . LEU A 1 298 ? 46.734 -14.613 -17.008 1.00 21.58  ? 292 LEU A CG  1 
ATOM 2403 C CD1 . LEU A 1 298 ? 47.699 -13.682 -16.287 1.00 20.25  ? 292 LEU A CD1 1 
ATOM 2404 C CD2 . LEU A 1 298 ? 45.332 -14.495 -16.426 1.00 23.61  ? 292 LEU A CD2 1 
ATOM 2405 N N   . ASP A 1 299 ? 47.297 -15.101 -21.548 1.00 34.24  ? 293 ASP A N   1 
ATOM 2406 C CA  . ASP A 1 299 ? 47.374 -14.735 -22.957 1.00 27.31  ? 293 ASP A CA  1 
ATOM 2407 C C   . ASP A 1 299 ? 46.446 -15.599 -23.804 1.00 24.90  ? 293 ASP A C   1 
ATOM 2408 O O   . ASP A 1 299 ? 45.778 -15.096 -24.715 1.00 32.78  ? 293 ASP A O   1 
ATOM 2409 C CB  . ASP A 1 299 ? 48.818 -14.856 -23.450 1.00 33.64  ? 293 ASP A CB  1 
ATOM 2410 C CG  . ASP A 1 299 ? 49.722 -13.782 -22.880 1.00 43.50  ? 293 ASP A CG  1 
ATOM 2411 O OD1 . ASP A 1 299 ? 49.211 -12.863 -22.201 1.00 41.23  ? 293 ASP A OD1 1 
ATOM 2412 O OD2 . ASP A 1 299 ? 50.945 -13.854 -23.118 1.00 43.38  ? 293 ASP A OD2 1 
ATOM 2413 N N   . ALA A 1 300 ? 46.387 -16.904 -23.516 1.00 26.62  ? 294 ALA A N   1 
ATOM 2414 C CA  . ALA A 1 300 ? 45.502 -17.793 -24.262 1.00 25.23  ? 294 ALA A CA  1 
ATOM 2415 C C   . ALA A 1 300 ? 44.038 -17.434 -24.039 1.00 33.60  ? 294 ALA A C   1 
ATOM 2416 O O   . ALA A 1 300 ? 43.230 -17.496 -24.974 1.00 41.68  ? 294 ALA A O   1 
ATOM 2417 C CB  . ALA A 1 300 ? 45.767 -19.244 -23.864 1.00 26.87  ? 294 ALA A CB  1 
ATOM 2418 N N   . ILE A 1 301 ? 43.677 -17.057 -22.808 1.00 29.42  ? 295 ILE A N   1 
ATOM 2419 C CA  . ILE A 1 301 ? 42.310 -16.615 -22.539 1.00 25.48  ? 295 ILE A CA  1 
ATOM 2420 C C   . ILE A 1 301 ? 41.989 -15.354 -23.332 1.00 31.67  ? 295 ILE A C   1 
ATOM 2421 O O   . ILE A 1 301 ? 40.905 -15.232 -23.913 1.00 40.72  ? 295 ILE A O   1 
ATOM 2422 C CB  . ILE A 1 301 ? 42.091 -16.400 -21.030 1.00 26.76  ? 295 ILE A CB  1 
ATOM 2423 C CG1 . ILE A 1 301 ? 42.073 -17.738 -20.294 1.00 29.56  ? 295 ILE A CG1 1 
ATOM 2424 C CG2 . ILE A 1 301 ? 40.794 -15.641 -20.773 1.00 26.11  ? 295 ILE A CG2 1 
ATOM 2425 C CD1 . ILE A 1 301 ? 42.229 -17.615 -18.796 1.00 29.31  ? 295 ILE A CD1 1 
ATOM 2426 N N   . MET A 1 302 ? 42.920 -14.395 -23.371 1.00 25.56  ? 296 MET A N   1 
ATOM 2427 C CA  . MET A 1 302 ? 42.710 -13.193 -24.177 1.00 29.12  ? 296 MET A CA  1 
ATOM 2428 C C   . MET A 1 302 ? 42.497 -13.532 -25.649 1.00 37.89  ? 296 MET A C   1 
ATOM 2429 O O   . MET A 1 302 ? 41.591 -12.993 -26.297 1.00 38.11  ? 296 MET A O   1 
ATOM 2430 C CB  . MET A 1 302 ? 43.885 -12.227 -24.013 1.00 27.19  ? 296 MET A CB  1 
ATOM 2431 C CG  . MET A 1 302 ? 44.016 -11.629 -22.621 1.00 42.66  ? 296 MET A CG  1 
ATOM 2432 S SD  . MET A 1 302 ? 43.071 -10.093 -22.419 1.00 30.80  ? 296 MET A SD  1 
ATOM 2433 C CE  . MET A 1 302 ? 41.446 -10.704 -21.981 1.00 48.37  ? 296 MET A CE  1 
ATOM 2434 N N   . LYS A 1 303 ? 43.332 -14.420 -26.197 1.00 31.65  ? 297 LYS A N   1 
ATOM 2435 C CA  . LYS A 1 303 ? 43.233 -14.754 -27.617 1.00 29.84  ? 297 LYS A CA  1 
ATOM 2436 C C   . LYS A 1 303 ? 41.922 -15.467 -27.930 1.00 38.59  ? 297 LYS A C   1 
ATOM 2437 O O   . LYS A 1 303 ? 41.247 -15.146 -28.918 1.00 43.60  ? 297 LYS A O   1 
ATOM 2438 C CB  . LYS A 1 303 ? 44.429 -15.610 -28.036 1.00 35.04  ? 297 LYS A CB  1 
ATOM 2439 C CG  . LYS A 1 303 ? 45.758 -14.876 -27.975 1.00 32.14  ? 297 LYS A CG  1 
ATOM 2440 C CD  . LYS A 1 303 ? 46.926 -15.832 -28.130 1.00 21.96  ? 297 LYS A CD  1 
ATOM 2441 C CE  . LYS A 1 303 ? 48.232 -15.210 -27.658 1.00 37.46  ? 297 LYS A CE  1 
ATOM 2442 N NZ  . LYS A 1 303 ? 49.362 -16.178 -27.752 1.00 46.76  ? 297 LYS A NZ  1 
ATOM 2443 N N   . TYR A 1 304 ? 41.549 -16.448 -27.103 1.00 46.23  ? 298 TYR A N   1 
ATOM 2444 C CA  . TYR A 1 304 ? 40.286 -17.150 -27.305 1.00 45.80  ? 298 TYR A CA  1 
ATOM 2445 C C   . TYR A 1 304 ? 39.098 -16.208 -27.172 1.00 39.30  ? 298 TYR A C   1 
ATOM 2446 O O   . TYR A 1 304 ? 38.120 -16.324 -27.917 1.00 50.14  ? 298 TYR A O   1 
ATOM 2447 C CB  . TYR A 1 304 ? 40.153 -18.319 -26.326 1.00 39.42  ? 298 TYR A CB  1 
ATOM 2448 C CG  . TYR A 1 304 ? 40.824 -19.589 -26.804 1.00 87.35  ? 298 TYR A CG  1 
ATOM 2449 C CD1 . TYR A 1 304 ? 40.311 -20.292 -27.890 1.00 108.52 ? 298 TYR A CD1 1 
ATOM 2450 C CD2 . TYR A 1 304 ? 41.960 -20.088 -26.180 1.00 102.06 ? 298 TYR A CD2 1 
ATOM 2451 C CE1 . TYR A 1 304 ? 40.906 -21.454 -28.343 1.00 122.88 ? 298 TYR A CE1 1 
ATOM 2452 C CE2 . TYR A 1 304 ? 42.566 -21.259 -26.629 1.00 105.86 ? 298 TYR A CE2 1 
ATOM 2453 C CZ  . TYR A 1 304 ? 42.033 -21.935 -27.711 1.00 111.72 ? 298 TYR A CZ  1 
ATOM 2454 O OH  . TYR A 1 304 ? 42.620 -23.095 -28.167 1.00 84.74  ? 298 TYR A OH  1 
ATOM 2455 N N   . MET A 1 305 ? 39.162 -15.263 -26.233 1.00 35.96  ? 299 MET A N   1 
ATOM 2456 C CA  . MET A 1 305 ? 38.061 -14.317 -26.084 1.00 41.95  ? 299 MET A CA  1 
ATOM 2457 C C   . MET A 1 305 ? 37.937 -13.428 -27.316 1.00 28.02  ? 299 MET A C   1 
ATOM 2458 O O   . MET A 1 305 ? 36.831 -13.219 -27.834 1.00 20.70  ? 299 MET A O   1 
ATOM 2459 C CB  . MET A 1 305 ? 38.265 -13.479 -24.818 1.00 57.90  ? 299 MET A CB  1 
ATOM 2460 C CG  . MET A 1 305 ? 37.261 -12.363 -24.600 1.00 37.96  ? 299 MET A CG  1 
ATOM 2461 S SD  . MET A 1 305 ? 37.318 -11.791 -22.887 1.00 58.57  ? 299 MET A SD  1 
ATOM 2462 C CE  . MET A 1 305 ? 36.540 -13.164 -22.034 1.00 27.69  ? 299 MET A CE  1 
ATOM 2463 N N   . TYR A 1 306 ? 39.069 -12.912 -27.805 1.00 26.66  ? 300 TYR A N   1 
ATOM 2464 C CA  . TYR A 1 306 ? 39.072 -12.127 -29.037 1.00 42.71  ? 300 TYR A CA  1 
ATOM 2465 C C   . TYR A 1 306 ? 38.457 -12.906 -30.194 1.00 38.29  ? 300 TYR A C   1 
ATOM 2466 O O   . TYR A 1 306 ? 37.581 -12.397 -30.904 1.00 31.78  ? 300 TYR A O   1 
ATOM 2467 C CB  . TYR A 1 306 ? 40.503 -11.702 -29.380 1.00 46.29  ? 300 TYR A CB  1 
ATOM 2468 C CG  . TYR A 1 306 ? 40.612 -10.735 -30.543 1.00 39.84  ? 300 TYR A CG  1 
ATOM 2469 C CD1 . TYR A 1 306 ? 40.572 -11.188 -31.854 1.00 22.68  ? 300 TYR A CD1 1 
ATOM 2470 C CD2 . TYR A 1 306 ? 40.761 -9.371  -30.328 1.00 42.80  ? 300 TYR A CD2 1 
ATOM 2471 C CE1 . TYR A 1 306 ? 40.668 -10.309 -32.917 1.00 36.30  ? 300 TYR A CE1 1 
ATOM 2472 C CE2 . TYR A 1 306 ? 40.861 -8.484  -31.385 1.00 55.86  ? 300 TYR A CE2 1 
ATOM 2473 C CZ  . TYR A 1 306 ? 40.814 -8.960  -32.677 1.00 61.86  ? 300 TYR A CZ  1 
ATOM 2474 O OH  . TYR A 1 306 ? 40.913 -8.090  -33.739 1.00 57.92  ? 300 TYR A OH  1 
ATOM 2475 N N   . GLN A 1 307 ? 38.915 -14.142 -30.409 1.00 38.89  ? 301 GLN A N   1 
ATOM 2476 C CA  . GLN A 1 307 ? 38.430 -14.921 -31.545 1.00 34.42  ? 301 GLN A CA  1 
ATOM 2477 C C   . GLN A 1 307 ? 36.945 -15.240 -31.411 1.00 30.15  ? 301 GLN A C   1 
ATOM 2478 O O   . GLN A 1 307 ? 36.187 -15.124 -32.381 1.00 26.23  ? 301 GLN A O   1 
ATOM 2479 C CB  . GLN A 1 307 ? 39.251 -16.204 -31.696 1.00 39.37  ? 301 GLN A CB  1 
ATOM 2480 C CG  . GLN A 1 307 ? 40.662 -15.974 -32.218 1.00 44.92  ? 301 GLN A CG  1 
ATOM 2481 C CD  . GLN A 1 307 ? 41.523 -17.220 -32.151 1.00 66.18  ? 301 GLN A CD  1 
ATOM 2482 O OE1 . GLN A 1 307 ? 41.095 -18.257 -31.643 1.00 68.31  ? 301 GLN A OE1 1 
ATOM 2483 N NE2 . GLN A 1 307 ? 42.741 -17.127 -32.672 1.00 77.82  ? 301 GLN A NE2 1 
ATOM 2484 N N   . ARG A 1 308 ? 36.503 -15.624 -30.213 1.00 43.06  ? 302 ARG A N   1 
ATOM 2485 C CA  . ARG A 1 308 ? 35.095 -15.945 -30.007 1.00 41.32  ? 302 ARG A CA  1 
ATOM 2486 C C   . ARG A 1 308 ? 34.207 -14.730 -30.253 1.00 40.73  ? 302 ARG A C   1 
ATOM 2487 O O   . ARG A 1 308 ? 33.166 -14.833 -30.914 1.00 37.60  ? 302 ARG A O   1 
ATOM 2488 C CB  . ARG A 1 308 ? 34.894 -16.484 -28.592 1.00 52.65  ? 302 ARG A CB  1 
ATOM 2489 C CG  . ARG A 1 308 ? 33.448 -16.723 -28.203 1.00 55.58  ? 302 ARG A CG  1 
ATOM 2490 C CD  . ARG A 1 308 ? 33.370 -17.267 -26.789 1.00 81.31  ? 302 ARG A CD  1 
ATOM 2491 N NE  . ARG A 1 308 ? 33.859 -18.638 -26.696 1.00 88.91  ? 302 ARG A NE  1 
ATOM 2492 C CZ  . ARG A 1 308 ? 33.092 -19.718 -26.759 1.00 84.00  ? 302 ARG A CZ  1 
ATOM 2493 N NH1 . ARG A 1 308 ? 31.784 -19.627 -26.935 1.00 76.11  ? 302 ARG A NH1 1 
ATOM 2494 N NH2 . ARG A 1 308 ? 33.651 -20.918 -26.632 1.00 81.03  ? 302 ARG A NH2 1 
ATOM 2495 N N   . VAL A 1 309 ? 34.599 -13.565 -29.728 1.00 40.35  ? 303 VAL A N   1 
ATOM 2496 C CA  . VAL A 1 309 ? 33.779 -12.368 -29.903 1.00 33.52  ? 303 VAL A CA  1 
ATOM 2497 C C   . VAL A 1 309 ? 33.745 -11.960 -31.370 1.00 42.68  ? 303 VAL A C   1 
ATOM 2498 O O   . VAL A 1 309 ? 32.677 -11.684 -31.936 1.00 48.23  ? 303 VAL A O   1 
ATOM 2499 C CB  . VAL A 1 309 ? 34.299 -11.222 -29.019 1.00 32.33  ? 303 VAL A CB  1 
ATOM 2500 C CG1 . VAL A 1 309 ? 33.655 -9.900  -29.433 1.00 34.37  ? 303 VAL A CG1 1 
ATOM 2501 C CG2 . VAL A 1 309 ? 34.039 -11.518 -27.555 1.00 27.73  ? 303 VAL A CG2 1 
ATOM 2502 N N   . GLU A 1 310 ? 34.917 -11.910 -32.007 1.00 43.08  ? 304 GLU A N   1 
ATOM 2503 C CA  . GLU A 1 310 ? 35.022 -11.508 -33.402 1.00 41.07  ? 304 GLU A CA  1 
ATOM 2504 C C   . GLU A 1 310 ? 34.580 -12.599 -34.364 1.00 42.15  ? 304 GLU A C   1 
ATOM 2505 O O   . GLU A 1 310 ? 34.726 -12.424 -35.577 1.00 52.04  ? 304 GLU A O   1 
ATOM 2506 C CB  . GLU A 1 310 ? 36.458 -11.084 -33.722 1.00 53.93  ? 304 GLU A CB  1 
ATOM 2507 C CG  . GLU A 1 310 ? 36.932 -9.876  -32.927 1.00 55.21  ? 304 GLU A CG  1 
ATOM 2508 C CD  . GLU A 1 310 ? 36.011 -8.676  -33.069 1.00 82.98  ? 304 GLU A CD  1 
ATOM 2509 O OE1 . GLU A 1 310 ? 35.476 -8.455  -34.179 1.00 122.62 ? 304 GLU A OE1 1 
ATOM 2510 O OE2 . GLU A 1 310 ? 35.826 -7.951  -32.066 1.00 61.06  ? 304 GLU A OE2 1 
ATOM 2511 N N   . GLN A 1 311 ? 34.090 -13.732 -33.861 1.00 46.20  ? 305 GLN A N   1 
ATOM 2512 C CA  . GLN A 1 311 ? 33.334 -14.653 -34.703 1.00 32.72  ? 305 GLN A CA  1 
ATOM 2513 C C   . GLN A 1 311 ? 31.836 -14.494 -34.494 1.00 40.53  ? 305 GLN A C   1 
ATOM 2514 O O   . GLN A 1 311 ? 31.074 -14.436 -35.462 1.00 58.06  ? 305 GLN A O   1 
ATOM 2515 C CB  . GLN A 1 311 ? 33.698 -16.109 -34.412 1.00 31.59  ? 305 GLN A CB  1 
ATOM 2516 C CG  . GLN A 1 311 ? 35.003 -16.580 -34.980 1.00 74.68  ? 305 GLN A CG  1 
ATOM 2517 C CD  . GLN A 1 311 ? 35.358 -17.932 -34.436 1.00 86.13  ? 305 GLN A CD  1 
ATOM 2518 O OE1 . GLN A 1 311 ? 34.539 -18.580 -33.782 1.00 73.60  ? 305 GLN A OE1 1 
ATOM 2519 N NE2 . GLN A 1 311 ? 36.599 -18.340 -34.633 1.00 74.95  ? 305 GLN A NE2 1 
ATOM 2520 N N   . CYS A 1 312 ? 31.397 -14.453 -33.230 1.00 43.42  ? 306 CYS A N   1 
ATOM 2521 C CA  . CYS A 1 312 ? 29.969 -14.339 -32.947 1.00 40.45  ? 306 CYS A CA  1 
ATOM 2522 C C   . CYS A 1 312 ? 29.401 -13.018 -33.446 1.00 43.87  ? 306 CYS A C   1 
ATOM 2523 O O   . CYS A 1 312 ? 28.193 -12.914 -33.687 1.00 46.27  ? 306 CYS A O   1 
ATOM 2524 C CB  . CYS A 1 312 ? 29.705 -14.493 -31.448 1.00 38.74  ? 306 CYS A CB  1 
ATOM 2525 S SG  . CYS A 1 312 ? 30.099 -16.127 -30.775 1.00 94.26  ? 306 CYS A SG  1 
ATOM 2526 N N   . MET A 1 313 ? 30.247 -11.998 -33.606 1.00 51.58  ? 307 MET A N   1 
ATOM 2527 C CA  . MET A 1 313 ? 29.780 -10.767 -34.232 1.00 54.87  ? 307 MET A CA  1 
ATOM 2528 C C   . MET A 1 313 ? 29.665 -10.926 -35.743 1.00 46.96  ? 307 MET A C   1 
ATOM 2529 O O   . MET A 1 313 ? 28.753 -10.367 -36.363 1.00 40.42  ? 307 MET A O   1 
ATOM 2530 C CB  . MET A 1 313 ? 30.714 -9.610  -33.884 1.00 53.04  ? 307 MET A CB  1 
ATOM 2531 C CG  . MET A 1 313 ? 30.520 -9.048  -32.485 1.00 46.64  ? 307 MET A CG  1 
ATOM 2532 S SD  . MET A 1 313 ? 31.817 -7.874  -32.033 1.00 136.21 ? 307 MET A SD  1 
ATOM 2533 C CE  . MET A 1 313 ? 31.924 -6.888  -33.528 1.00 94.44  ? 307 MET A CE  1 
ATOM 2534 N N   . GLN A 1 314 ? 30.575 -11.691 -36.355 1.00 47.61  ? 308 GLN A N   1 
ATOM 2535 C CA  . GLN A 1 314 ? 30.542 -11.851 -37.806 1.00 56.71  ? 308 GLN A CA  1 
ATOM 2536 C C   . GLN A 1 314 ? 29.434 -12.799 -38.245 1.00 48.06  ? 308 GLN A C   1 
ATOM 2537 O O   . GLN A 1 314 ? 28.949 -12.699 -39.378 1.00 54.46  ? 308 GLN A O   1 
ATOM 2538 C CB  . GLN A 1 314 ? 31.891 -12.353 -38.319 1.00 53.22  ? 308 GLN A CB  1 
ATOM 2539 C CG  . GLN A 1 314 ? 33.070 -11.478 -37.931 1.00 77.28  ? 308 GLN A CG  1 
ATOM 2540 C CD  . GLN A 1 314 ? 32.847 -10.011 -38.215 1.00 96.63  ? 308 GLN A CD  1 
ATOM 2541 O OE1 . GLN A 1 314 ? 32.427 -9.636  -39.310 1.00 68.31  ? 308 GLN A OE1 1 
ATOM 2542 N NE2 . GLN A 1 314 ? 33.125 -9.166  -37.225 1.00 92.04  ? 308 GLN A NE2 1 
ATOM 2543 N N   . SER A 1 315 ? 29.032 -13.728 -37.378 1.00 51.97  ? 309 SER A N   1 
ATOM 2544 C CA  . SER A 1 315 ? 27.944 -14.646 -37.679 1.00 58.73  ? 309 SER A CA  1 
ATOM 2545 C C   . SER A 1 315 ? 26.595 -14.148 -37.180 1.00 57.19  ? 309 SER A C   1 
ATOM 2546 O O   . SER A 1 315 ? 25.566 -14.737 -37.531 1.00 33.54  ? 309 SER A O   1 
ATOM 2547 C CB  . SER A 1 315 ? 28.232 -16.033 -37.088 1.00 51.83  ? 309 SER A CB  1 
ATOM 2548 O OG  . SER A 1 315 ? 28.278 -15.992 -35.674 1.00 82.59  ? 309 SER A OG  1 
ATOM 2549 N N   . ASN A 1 316 ? 26.575 -13.083 -36.379 1.00 66.54  ? 310 ASN A N   1 
ATOM 2550 C CA  . ASN A 1 316 ? 25.343 -12.410 -35.966 1.00 68.06  ? 310 ASN A CA  1 
ATOM 2551 C C   . ASN A 1 316 ? 25.407 -10.936 -36.356 1.00 65.66  ? 310 ASN A C   1 
ATOM 2552 O O   . ASN A 1 316 ? 25.415 -10.051 -35.490 1.00 56.74  ? 310 ASN A O   1 
ATOM 2553 C CB  . ASN A 1 316 ? 25.113 -12.561 -34.465 1.00 53.85  ? 310 ASN A CB  1 
ATOM 2554 C CG  . ASN A 1 316 ? 24.785 -13.985 -34.063 1.00 72.54  ? 310 ASN A CG  1 
ATOM 2555 O OD1 . ASN A 1 316 ? 23.627 -14.396 -34.084 1.00 85.36  ? 310 ASN A OD1 1 
ATOM 2556 N ND2 . ASN A 1 316 ? 25.809 -14.747 -33.693 1.00 58.42  ? 310 ASN A ND2 1 
ATOM 2557 N N   . PRO A 1 317 ? 25.445 -10.633 -37.652 1.00 60.78  ? 311 PRO A N   1 
ATOM 2558 C CA  . PRO A 1 317 ? 25.638 -9.245  -38.078 1.00 56.58  ? 311 PRO A CA  1 
ATOM 2559 C C   . PRO A 1 317 ? 24.384 -8.408  -37.875 1.00 58.90  ? 311 PRO A C   1 
ATOM 2560 O O   . PRO A 1 317 ? 23.269 -8.919  -37.747 1.00 67.64  ? 311 PRO A O   1 
ATOM 2561 C CB  . PRO A 1 317 ? 25.978 -9.380  -39.564 1.00 67.29  ? 311 PRO A CB  1 
ATOM 2562 C CG  . PRO A 1 317 ? 25.202 -10.582 -39.984 1.00 59.68  ? 311 PRO A CG  1 
ATOM 2563 C CD  . PRO A 1 317 ? 25.266 -11.533 -38.809 1.00 50.73  ? 311 PRO A CD  1 
ATOM 2564 N N   . GLY A 1 318 ? 24.587 -7.093  -37.855 1.00 49.97  ? 312 GLY A N   1 
ATOM 2565 C CA  . GLY A 1 318 ? 23.488 -6.169  -37.651 1.00 50.10  ? 312 GLY A CA  1 
ATOM 2566 C C   . GLY A 1 318 ? 22.926 -6.167  -36.248 1.00 63.77  ? 312 GLY A C   1 
ATOM 2567 O O   . GLY A 1 318 ? 21.723 -5.947  -36.071 1.00 70.64  ? 312 GLY A O   1 
ATOM 2568 N N   . CYS A 1 319 ? 23.765 -6.404  -35.242 1.00 71.97  ? 313 CYS A N   1 
ATOM 2569 C CA  . CYS A 1 319 ? 23.346 -6.443  -33.841 1.00 78.01  ? 313 CYS A CA  1 
ATOM 2570 C C   . CYS A 1 319 ? 24.287 -5.551  -33.046 1.00 75.54  ? 313 CYS A C   1 
ATOM 2571 O O   . CYS A 1 319 ? 25.232 -6.036  -32.408 1.00 77.90  ? 313 CYS A O   1 
ATOM 2572 C CB  . CYS A 1 319 ? 23.344 -7.876  -33.307 1.00 74.34  ? 313 CYS A CB  1 
ATOM 2573 S SG  . CYS A 1 319 ? 22.197 -8.985  -34.158 1.00 76.40  ? 313 CYS A SG  1 
ATOM 2574 N N   . PRO A 1 320 ? 24.062 -4.232  -33.059 1.00 61.64  ? 314 PRO A N   1 
ATOM 2575 C CA  . PRO A 1 320 ? 24.985 -3.334  -32.344 1.00 61.05  ? 314 PRO A CA  1 
ATOM 2576 C C   . PRO A 1 320 ? 24.908 -3.484  -30.837 1.00 61.98  ? 314 PRO A C   1 
ATOM 2577 O O   . PRO A 1 320 ? 25.928 -3.340  -30.149 1.00 61.87  ? 314 PRO A O   1 
ATOM 2578 C CB  . PRO A 1 320 ? 24.535 -1.938  -32.799 1.00 39.90  ? 314 PRO A CB  1 
ATOM 2579 C CG  . PRO A 1 320 ? 23.089 -2.114  -33.158 1.00 28.70  ? 314 PRO A CG  1 
ATOM 2580 C CD  . PRO A 1 320 ? 22.973 -3.500  -33.729 1.00 49.22  ? 314 PRO A CD  1 
ATOM 2581 N N   . GLN A 1 321 ? 23.711 -3.746  -30.306 1.00 63.99  ? 315 GLN A N   1 
ATOM 2582 C CA  . GLN A 1 321 ? 23.542 -3.970  -28.873 1.00 62.77  ? 315 GLN A CA  1 
ATOM 2583 C C   . GLN A 1 321 ? 24.430 -5.115  -28.395 1.00 60.30  ? 315 GLN A C   1 
ATOM 2584 O O   . GLN A 1 321 ? 25.110 -5.013  -27.365 1.00 67.18  ? 315 GLN A O   1 
ATOM 2585 C CB  . GLN A 1 321 ? 22.067 -4.260  -28.583 1.00 60.35  ? 315 GLN A CB  1 
ATOM 2586 C CG  . GLN A 1 321 ? 21.151 -3.105  -28.981 1.00 74.54  ? 315 GLN A CG  1 
ATOM 2587 C CD  . GLN A 1 321 ? 19.689 -3.364  -28.675 1.00 90.08  ? 315 GLN A CD  1 
ATOM 2588 O OE1 . GLN A 1 321 ? 18.892 -3.632  -29.575 1.00 92.82  ? 315 GLN A OE1 1 
ATOM 2589 N NE2 . GLN A 1 321 ? 19.328 -3.283  -27.402 1.00 84.35  ? 315 GLN A NE2 1 
ATOM 2590 N N   . LEU A 1 322 ? 24.444 -6.212  -29.157 1.00 52.50  ? 316 LEU A N   1 
ATOM 2591 C CA  . LEU A 1 322 ? 25.329 -7.330  -28.854 1.00 48.96  ? 316 LEU A CA  1 
ATOM 2592 C C   . LEU A 1 322 ? 26.790 -6.903  -28.886 1.00 47.78  ? 316 LEU A C   1 
ATOM 2593 O O   . LEU A 1 322 ? 27.586 -7.332  -28.044 1.00 40.61  ? 316 LEU A O   1 
ATOM 2594 C CB  . LEU A 1 322 ? 25.082 -8.466  -29.848 1.00 38.75  ? 316 LEU A CB  1 
ATOM 2595 C CG  . LEU A 1 322 ? 25.928 -9.728  -29.719 1.00 28.96  ? 316 LEU A CG  1 
ATOM 2596 C CD1 . LEU A 1 322 ? 25.737 -10.348 -28.354 1.00 36.61  ? 316 LEU A CD1 1 
ATOM 2597 C CD2 . LEU A 1 322 ? 25.561 -10.704 -30.820 1.00 47.84  ? 316 LEU A CD2 1 
ATOM 2598 N N   . GLU A 1 323 ? 27.165 -6.078  -29.869 1.00 54.56  ? 317 GLU A N   1 
ATOM 2599 C CA  . GLU A 1 323 ? 28.546 -5.617  -29.976 1.00 45.87  ? 317 GLU A CA  1 
ATOM 2600 C C   . GLU A 1 323 ? 28.967 -4.867  -28.720 1.00 59.76  ? 317 GLU A C   1 
ATOM 2601 O O   . GLU A 1 323 ? 30.017 -5.154  -28.133 1.00 63.04  ? 317 GLU A O   1 
ATOM 2602 C CB  . GLU A 1 323 ? 28.709 -4.727  -31.210 1.00 53.89  ? 317 GLU A CB  1 
ATOM 2603 C CG  . GLU A 1 323 ? 28.498 -5.437  -32.535 1.00 91.95  ? 317 GLU A CG  1 
ATOM 2604 C CD  . GLU A 1 323 ? 28.483 -4.478  -33.715 1.00 111.36 ? 317 GLU A CD  1 
ATOM 2605 O OE1 . GLU A 1 323 ? 28.662 -3.261  -33.501 1.00 97.08  ? 317 GLU A OE1 1 
ATOM 2606 O OE2 . GLU A 1 323 ? 28.265 -4.936  -34.856 1.00 128.77 ? 317 GLU A OE2 1 
ATOM 2607 N N   . SER A 1 324 ? 28.153 -3.893  -28.297 1.00 67.73  ? 318 SER A N   1 
ATOM 2608 C CA  . SER A 1 324 ? 28.464 -3.138  -27.088 1.00 46.49  ? 318 SER A CA  1 
ATOM 2609 C C   . SER A 1 324 ? 28.523 -4.047  -25.867 1.00 45.13  ? 318 SER A C   1 
ATOM 2610 O O   . SER A 1 324 ? 29.396 -3.880  -25.010 1.00 42.56  ? 318 SER A O   1 
ATOM 2611 C CB  . SER A 1 324 ? 27.437 -2.023  -26.876 1.00 36.01  ? 318 SER A CB  1 
ATOM 2612 O OG  . SER A 1 324 ? 26.116 -2.529  -26.899 1.00 66.92  ? 318 SER A OG  1 
ATOM 2613 N N   . LEU A 1 325 ? 27.610 -5.020  -25.772 1.00 41.53  ? 319 LEU A N   1 
ATOM 2614 C CA  . LEU A 1 325 ? 27.628 -5.942  -24.635 1.00 40.91  ? 319 LEU A CA  1 
ATOM 2615 C C   . LEU A 1 325 ? 28.918 -6.757  -24.600 1.00 37.06  ? 319 LEU A C   1 
ATOM 2616 O O   . LEU A 1 325 ? 29.536 -6.927  -23.537 1.00 28.38  ? 319 LEU A O   1 
ATOM 2617 C CB  . LEU A 1 325 ? 26.412 -6.867  -24.698 1.00 45.22  ? 319 LEU A CB  1 
ATOM 2618 C CG  . LEU A 1 325 ? 26.358 -8.092  -23.779 1.00 34.14  ? 319 LEU A CG  1 
ATOM 2619 C CD1 . LEU A 1 325 ? 26.297 -7.710  -22.303 1.00 30.81  ? 319 LEU A CD1 1 
ATOM 2620 C CD2 . LEU A 1 325 ? 25.192 -8.983  -24.158 1.00 48.79  ? 319 LEU A CD2 1 
ATOM 2621 N N   . LEU A 1 326 ? 29.343 -7.265  -25.758 1.00 40.72  ? 320 LEU A N   1 
ATOM 2622 C CA  . LEU A 1 326 ? 30.574 -8.042  -25.820 1.00 42.71  ? 320 LEU A CA  1 
ATOM 2623 C C   . LEU A 1 326 ? 31.779 -7.178  -25.479 1.00 36.49  ? 320 LEU A C   1 
ATOM 2624 O O   . LEU A 1 326 ? 32.702 -7.633  -24.792 1.00 36.17  ? 320 LEU A O   1 
ATOM 2625 C CB  . LEU A 1 326 ? 30.736 -8.663  -27.207 1.00 38.48  ? 320 LEU A CB  1 
ATOM 2626 C CG  . LEU A 1 326 ? 29.708 -9.742  -27.550 1.00 30.34  ? 320 LEU A CG  1 
ATOM 2627 C CD1 . LEU A 1 326 ? 29.829 -10.163 -29.009 1.00 38.60  ? 320 LEU A CD1 1 
ATOM 2628 C CD2 . LEU A 1 326 ? 29.805 -10.936 -26.610 1.00 18.89  ? 320 LEU A CD2 1 
ATOM 2629 N N   . GLU A 1 327 ? 31.789 -5.928  -25.946 1.00 31.03  ? 321 GLU A N   1 
ATOM 2630 C CA  . GLU A 1 327 ? 32.883 -5.030  -25.595 1.00 36.97  ? 321 GLU A CA  1 
ATOM 2631 C C   . GLU A 1 327 ? 32.902 -4.738  -24.102 1.00 38.13  ? 321 GLU A C   1 
ATOM 2632 O O   . GLU A 1 327 ? 33.973 -4.594  -23.505 1.00 36.90  ? 321 GLU A O   1 
ATOM 2633 C CB  . GLU A 1 327 ? 32.795 -3.731  -26.394 1.00 37.51  ? 321 GLU A CB  1 
ATOM 2634 C CG  . GLU A 1 327 ? 33.212 -3.870  -27.842 1.00 33.78  ? 321 GLU A CG  1 
ATOM 2635 C CD  . GLU A 1 327 ? 34.680 -4.224  -27.984 1.00 58.68  ? 321 GLU A CD  1 
ATOM 2636 O OE1 . GLU A 1 327 ? 35.529 -3.471  -27.462 1.00 58.90  ? 321 GLU A OE1 1 
ATOM 2637 O OE2 . GLU A 1 327 ? 34.986 -5.250  -28.629 1.00 73.99  ? 321 GLU A OE2 1 
ATOM 2638 N N   . THR A 1 328 ? 31.727 -4.658  -23.476 1.00 33.96  ? 322 THR A N   1 
ATOM 2639 C CA  . THR A 1 328 ? 31.687 -4.485  -22.027 1.00 33.92  ? 322 THR A CA  1 
ATOM 2640 C C   . THR A 1 328 ? 32.284 -5.696  -21.316 1.00 30.15  ? 322 THR A C   1 
ATOM 2641 O O   . THR A 1 328 ? 33.037 -5.550  -20.344 1.00 32.06  ? 322 THR A O   1 
ATOM 2642 C CB  . THR A 1 328 ? 30.249 -4.244  -21.560 1.00 37.36  ? 322 THR A CB  1 
ATOM 2643 O OG1 . THR A 1 328 ? 29.730 -3.064  -22.189 1.00 47.43  ? 322 THR A OG1 1 
ATOM 2644 C CG2 . THR A 1 328 ? 30.197 -4.068  -20.040 1.00 27.04  ? 322 THR A CG2 1 
ATOM 2645 N N   . THR A 1 329 ? 31.954 -6.903  -21.785 1.00 24.18  ? 323 THR A N   1 
ATOM 2646 C CA  . THR A 1 329 ? 32.534 -8.104  -21.181 1.00 27.17  ? 323 THR A CA  1 
ATOM 2647 C C   . THR A 1 329 ? 34.050 -8.121  -21.334 1.00 25.64  ? 323 THR A C   1 
ATOM 2648 O O   . THR A 1 329 ? 34.779 -8.475  -20.398 1.00 38.67  ? 323 THR A O   1 
ATOM 2649 C CB  . THR A 1 329 ? 31.929 -9.366  -21.799 1.00 21.07  ? 323 THR A CB  1 
ATOM 2650 O OG1 . THR A 1 329 ? 30.498 -9.298  -21.745 1.00 22.78  ? 323 THR A OG1 1 
ATOM 2651 C CG2 . THR A 1 329 ? 32.417 -10.609 -21.056 1.00 17.17  ? 323 THR A CG2 1 
ATOM 2652 N N   . ILE A 1 330 ? 34.541 -7.750  -22.516 1.00 23.59  ? 324 ILE A N   1 
ATOM 2653 C CA  . ILE A 1 330 ? 35.983 -7.644  -22.725 1.00 27.12  ? 324 ILE A CA  1 
ATOM 2654 C C   . ILE A 1 330 ? 36.598 -6.647  -21.748 1.00 30.66  ? 324 ILE A C   1 
ATOM 2655 O O   . ILE A 1 330 ? 37.636 -6.920  -21.128 1.00 26.67  ? 324 ILE A O   1 
ATOM 2656 C CB  . ILE A 1 330 ? 36.275 -7.263  -24.187 1.00 23.93  ? 324 ILE A CB  1 
ATOM 2657 C CG1 . ILE A 1 330 ? 36.080 -8.478  -25.098 1.00 26.99  ? 324 ILE A CG1 1 
ATOM 2658 C CG2 . ILE A 1 330 ? 37.669 -6.679  -24.321 1.00 31.03  ? 324 ILE A CG2 1 
ATOM 2659 C CD1 . ILE A 1 330 ? 35.974 -8.136  -26.571 1.00 33.97  ? 324 ILE A CD1 1 
ATOM 2660 N N   . TYR A 1 331 ? 35.972 -5.473  -21.608 1.00 35.57  ? 325 TYR A N   1 
ATOM 2661 C CA  . TYR A 1 331 ? 36.450 -4.453  -20.677 1.00 34.25  ? 325 TYR A CA  1 
ATOM 2662 C C   . TYR A 1 331 ? 36.572 -5.011  -19.267 1.00 28.43  ? 325 TYR A C   1 
ATOM 2663 O O   . TYR A 1 331 ? 37.587 -4.809  -18.589 1.00 21.75  ? 325 TYR A O   1 
ATOM 2664 C CB  . TYR A 1 331 ? 35.498 -3.252  -20.701 1.00 35.88  ? 325 TYR A CB  1 
ATOM 2665 C CG  . TYR A 1 331 ? 35.908 -2.103  -19.803 1.00 30.14  ? 325 TYR A CG  1 
ATOM 2666 C CD1 . TYR A 1 331 ? 35.567 -2.096  -18.454 1.00 30.97  ? 325 TYR A CD1 1 
ATOM 2667 C CD2 . TYR A 1 331 ? 36.609 -1.014  -20.305 1.00 33.95  ? 325 TYR A CD2 1 
ATOM 2668 C CE1 . TYR A 1 331 ? 35.932 -1.054  -17.624 1.00 33.40  ? 325 TYR A CE1 1 
ATOM 2669 C CE2 . TYR A 1 331 ? 36.976 0.039   -19.480 1.00 35.18  ? 325 TYR A CE2 1 
ATOM 2670 C CZ  . TYR A 1 331 ? 36.633 0.012   -18.140 1.00 38.75  ? 325 TYR A CZ  1 
ATOM 2671 O OH  . TYR A 1 331 ? 36.991 1.050   -17.308 1.00 56.71  ? 325 TYR A OH  1 
ATOM 2672 N N   . THR A 1 332 ? 35.533 -5.703  -18.802 1.00 41.46  ? 326 THR A N   1 
ATOM 2673 C CA  . THR A 1 332 ? 35.542 -6.216  -17.438 1.00 42.53  ? 326 THR A CA  1 
ATOM 2674 C C   . THR A 1 332 ? 36.528 -7.365  -17.257 1.00 34.16  ? 326 THR A C   1 
ATOM 2675 O O   . THR A 1 332 ? 37.011 -7.577  -16.140 1.00 39.20  ? 326 THR A O   1 
ATOM 2676 C CB  . THR A 1 332 ? 34.140 -6.666  -17.030 1.00 38.84  ? 326 THR A CB  1 
ATOM 2677 O OG1 . THR A 1 332 ? 33.644 -7.623  -17.973 1.00 51.94  ? 326 THR A OG1 1 
ATOM 2678 C CG2 . THR A 1 332 ? 33.207 -5.481  -17.014 1.00 32.00  ? 326 THR A CG2 1 
ATOM 2679 N N   . THR A 1 333 ? 36.837 -8.110  -18.324 1.00 38.86  ? 327 THR A N   1 
ATOM 2680 C CA  . THR A 1 333 ? 37.868 -9.142  -18.223 1.00 36.81  ? 327 THR A CA  1 
ATOM 2681 C C   . THR A 1 333 ? 39.261 -8.526  -18.155 1.00 36.43  ? 327 THR A C   1 
ATOM 2682 O O   . THR A 1 333 ? 40.138 -9.018  -17.433 1.00 37.16  ? 327 THR A O   1 
ATOM 2683 C CB  . THR A 1 333 ? 37.779 -10.099 -19.408 1.00 24.83  ? 327 THR A CB  1 
ATOM 2684 O OG1 . THR A 1 333 ? 36.468 -10.681 -19.456 1.00 26.44  ? 327 THR A OG1 1 
ATOM 2685 C CG2 . THR A 1 333 ? 38.824 -11.201 -19.272 1.00 23.46  ? 327 THR A CG2 1 
ATOM 2686 N N   . VAL A 1 334 ? 39.485 -7.444  -18.899 1.00 39.19  ? 328 VAL A N   1 
ATOM 2687 C CA  . VAL A 1 334 ? 40.794 -6.799  -18.877 1.00 38.51  ? 328 VAL A CA  1 
ATOM 2688 C C   . VAL A 1 334 ? 40.994 -5.983  -17.604 1.00 32.02  ? 328 VAL A C   1 
ATOM 2689 O O   . VAL A 1 334 ? 42.133 -5.816  -17.149 1.00 36.41  ? 328 VAL A O   1 
ATOM 2690 C CB  . VAL A 1 334 ? 40.965 -5.936  -20.143 1.00 33.82  ? 328 VAL A CB  1 
ATOM 2691 C CG1 . VAL A 1 334 ? 42.183 -5.026  -20.059 1.00 19.19  ? 328 VAL A CG1 1 
ATOM 2692 C CG2 . VAL A 1 334 ? 41.060 -6.825  -21.386 1.00 38.16  ? 328 VAL A CG2 1 
ATOM 2693 N N   . GLY A 1 335 ? 39.911 -5.501  -16.996 1.00 28.00  ? 329 GLY A N   1 
ATOM 2694 C CA  . GLY A 1 335 ? 40.005 -4.678  -15.806 1.00 34.81  ? 329 GLY A CA  1 
ATOM 2695 C C   . GLY A 1 335 ? 40.605 -5.361  -14.596 1.00 30.95  ? 329 GLY A C   1 
ATOM 2696 O O   . GLY A 1 335 ? 40.969 -4.663  -13.645 1.00 38.51  ? 329 GLY A O   1 
ATOM 2697 N N   . TRP A 1 336 ? 40.724 -6.691  -14.600 1.00 33.77  ? 330 TRP A N   1 
ATOM 2698 C CA  . TRP A 1 336 ? 41.274 -7.378  -13.433 1.00 30.71  ? 330 TRP A CA  1 
ATOM 2699 C C   . TRP A 1 336 ? 42.774 -7.127  -13.295 1.00 41.09  ? 330 TRP A C   1 
ATOM 2700 O O   . TRP A 1 336 ? 43.296 -7.054  -12.176 1.00 34.53  ? 330 TRP A O   1 
ATOM 2701 C CB  . TRP A 1 336 ? 40.964 -8.871  -13.518 1.00 23.67  ? 330 TRP A CB  1 
ATOM 2702 C CG  . TRP A 1 336 ? 39.526 -9.168  -13.263 1.00 20.25  ? 330 TRP A CG  1 
ATOM 2703 C CD1 . TRP A 1 336 ? 38.608 -9.600  -14.173 1.00 23.48  ? 330 TRP A CD1 1 
ATOM 2704 C CD2 . TRP A 1 336 ? 38.829 -9.048  -12.013 1.00 42.30  ? 330 TRP A CD2 1 
ATOM 2705 N NE1 . TRP A 1 336 ? 37.382 -9.760  -13.568 1.00 26.29  ? 330 TRP A NE1 1 
ATOM 2706 C CE2 . TRP A 1 336 ? 37.491 -9.428  -12.242 1.00 33.93  ? 330 TRP A CE2 1 
ATOM 2707 C CE3 . TRP A 1 336 ? 39.208 -8.658  -10.723 1.00 82.78  ? 330 TRP A CE3 1 
ATOM 2708 C CZ2 . TRP A 1 336 ? 36.530 -9.430  -11.231 1.00 52.05  ? 330 TRP A CZ2 1 
ATOM 2709 C CZ3 . TRP A 1 336 ? 38.248 -8.664  -9.716  1.00 83.57  ? 330 TRP A CZ3 1 
ATOM 2710 C CH2 . TRP A 1 336 ? 36.928 -9.045  -9.978  1.00 65.53  ? 330 TRP A CH2 1 
ATOM 2711 N N   . ILE A 1 337 ? 43.478 -6.967  -14.419 1.00 38.51  ? 331 ILE A N   1 
ATOM 2712 C CA  . ILE A 1 337 ? 44.876 -6.531  -14.382 1.00 26.17  ? 331 ILE A CA  1 
ATOM 2713 C C   . ILE A 1 337 ? 44.989 -5.207  -13.636 1.00 37.06  ? 331 ILE A C   1 
ATOM 2714 O O   . ILE A 1 337 ? 45.739 -5.074  -12.660 1.00 48.17  ? 331 ILE A O   1 
ATOM 2715 C CB  . ILE A 1 337 ? 45.433 -6.399  -15.809 1.00 22.63  ? 331 ILE A CB  1 
ATOM 2716 C CG1 . ILE A 1 337 ? 45.016 -7.594  -16.659 1.00 31.37  ? 331 ILE A CG1 1 
ATOM 2717 C CG2 . ILE A 1 337 ? 46.949 -6.258  -15.777 1.00 14.89  ? 331 ILE A CG2 1 
ATOM 2718 C CD1 . ILE A 1 337 ? 45.235 -7.388  -18.141 1.00 26.13  ? 331 ILE A CD1 1 
ATOM 2719 N N   . ARG A 1 338 ? 44.257 -4.203  -14.121 1.00 37.97  ? 332 ARG A N   1 
ATOM 2720 C CA  . ARG A 1 338 ? 44.210 -2.887  -13.492 1.00 25.19  ? 332 ARG A CA  1 
ATOM 2721 C C   . ARG A 1 338 ? 43.887 -2.991  -12.004 1.00 24.53  ? 332 ARG A C   1 
ATOM 2722 O O   . ARG A 1 338 ? 44.536 -2.354  -11.164 1.00 22.73  ? 332 ARG A O   1 
ATOM 2723 C CB  . ARG A 1 338 ? 43.170 -2.040  -14.227 1.00 26.77  ? 332 ARG A CB  1 
ATOM 2724 C CG  . ARG A 1 338 ? 42.965 -0.639  -13.726 1.00 28.96  ? 332 ARG A CG  1 
ATOM 2725 C CD  . ARG A 1 338 ? 41.893 0.003   -14.583 1.00 28.96  ? 332 ARG A CD  1 
ATOM 2726 N NE  . ARG A 1 338 ? 41.650 1.399   -14.250 1.00 36.47  ? 332 ARG A NE  1 
ATOM 2727 C CZ  . ARG A 1 338 ? 40.639 2.107   -14.734 1.00 61.35  ? 332 ARG A CZ  1 
ATOM 2728 N NH1 . ARG A 1 338 ? 39.754 1.573   -15.561 1.00 53.77  ? 332 ARG A NH1 1 
ATOM 2729 N NH2 . ARG A 1 338 ? 40.515 3.384   -14.386 1.00 91.63  ? 332 ARG A NH2 1 
ATOM 2730 N N   . SER A 1 339 ? 42.891 -3.814  -11.664 1.00 43.25  ? 333 SER A N   1 
ATOM 2731 C CA  . SER A 1 339 ? 42.465 -3.952  -10.273 1.00 41.11  ? 333 SER A CA  1 
ATOM 2732 C C   . SER A 1 339 ? 43.580 -4.504  -9.398  1.00 38.22  ? 333 SER A C   1 
ATOM 2733 O O   . SER A 1 339 ? 43.857 -3.971  -8.317  1.00 39.24  ? 333 SER A O   1 
ATOM 2734 C CB  . SER A 1 339 ? 41.224 -4.846  -10.170 1.00 32.57  ? 333 SER A CB  1 
ATOM 2735 O OG  . SER A 1 339 ? 40.102 -4.247  -10.784 1.00 34.26  ? 333 SER A OG  1 
ATOM 2736 N N   . HIS A 1 340 ? 44.229 -5.579  -9.847  1.00 46.69  ? 334 HIS A N   1 
ATOM 2737 C CA  . HIS A 1 340 ? 45.283 -6.183  -9.041  1.00 42.47  ? 334 HIS A CA  1 
ATOM 2738 C C   . HIS A 1 340 ? 46.516 -5.292  -8.981  1.00 37.26  ? 334 HIS A C   1 
ATOM 2739 O O   . HIS A 1 340 ? 47.304 -5.388  -8.033  1.00 45.63  ? 334 HIS A O   1 
ATOM 2740 C CB  . HIS A 1 340 ? 45.646 -7.561  -9.597  1.00 34.30  ? 334 HIS A CB  1 
ATOM 2741 C CG  . HIS A 1 340 ? 44.688 -8.642  -9.209  1.00 35.19  ? 334 HIS A CG  1 
ATOM 2742 N ND1 . HIS A 1 340 ? 43.571 -8.946  -9.957  1.00 51.13  ? 334 HIS A ND1 1 
ATOM 2743 C CD2 . HIS A 1 340 ? 44.690 -9.507  -8.167  1.00 42.74  ? 334 HIS A CD2 1 
ATOM 2744 C CE1 . HIS A 1 340 ? 42.918 -9.940  -9.385  1.00 45.01  ? 334 HIS A CE1 1 
ATOM 2745 N NE2 . HIS A 1 340 ? 43.576 -10.300 -8.297  1.00 56.01  ? 334 HIS A NE2 1 
ATOM 2746 N N   . THR A 1 341 ? 46.702 -4.419  -9.972  1.00 28.98  ? 335 THR A N   1 
ATOM 2747 C CA  . THR A 1 341 ? 47.902 -3.591  -9.977  1.00 27.86  ? 335 THR A CA  1 
ATOM 2748 C C   . THR A 1 341 ? 47.752 -2.354  -9.102  1.00 38.52  ? 335 THR A C   1 
ATOM 2749 O O   . THR A 1 341 ? 48.693 -1.989  -8.389  1.00 64.62  ? 335 THR A O   1 
ATOM 2750 C CB  . THR A 1 341 ? 48.270 -3.188  -11.407 1.00 47.12  ? 335 THR A CB  1 
ATOM 2751 O OG1 . THR A 1 341 ? 47.128 -2.634  -12.072 1.00 63.07  ? 335 THR A OG1 1 
ATOM 2752 C CG2 . THR A 1 341 ? 48.765 -4.390  -12.176 1.00 35.19  ? 335 THR A CG2 1 
ATOM 2753 N N   . THR A 1 342 ? 46.589 -1.698  -9.125  1.00 48.85  ? 336 THR A N   1 
ATOM 2754 C CA  . THR A 1 342 ? 46.555 -0.358  -8.543  1.00 58.09  ? 336 THR A CA  1 
ATOM 2755 C C   . THR A 1 342 ? 45.459 -0.089  -7.514  1.00 55.33  ? 336 THR A C   1 
ATOM 2756 O O   . THR A 1 342 ? 45.659 0.736   -6.619  1.00 59.12  ? 336 THR A O   1 
ATOM 2757 C CB  . THR A 1 342 ? 46.443 0.688   -9.657  1.00 53.60  ? 336 THR A CB  1 
ATOM 2758 O OG1 . THR A 1 342 ? 45.428 0.295   -10.588 1.00 63.68  ? 336 THR A OG1 1 
ATOM 2759 C CG2 . THR A 1 342 ? 47.769 0.829   -10.392 1.00 25.92  ? 336 THR A CG2 1 
ATOM 2760 N N   . VAL A 1 343 ? 44.298 -0.731  -7.617  1.00 44.48  ? 337 VAL A N   1 
ATOM 2761 C CA  . VAL A 1 343 ? 43.135 -0.284  -6.853  1.00 47.44  ? 337 VAL A CA  1 
ATOM 2762 C C   . VAL A 1 343 ? 42.838 -1.157  -5.642  1.00 49.14  ? 337 VAL A C   1 
ATOM 2763 O O   . VAL A 1 343 ? 42.092 -0.712  -4.756  1.00 51.64  ? 337 VAL A O   1 
ATOM 2764 C CB  . VAL A 1 343 ? 41.881 -0.186  -7.741  1.00 38.47  ? 337 VAL A CB  1 
ATOM 2765 C CG1 . VAL A 1 343 ? 42.133 0.776   -8.880  1.00 31.16  ? 337 VAL A CG1 1 
ATOM 2766 C CG2 . VAL A 1 343 ? 41.410 -1.538  -8.192  1.00 51.42  ? 337 VAL A CG2 1 
ATOM 2767 N N   . VAL A 1 344 ? 43.370 -2.371  -5.570  1.00 60.79  ? 338 VAL A N   1 
ATOM 2768 C CA  . VAL A 1 344 ? 43.164 -3.240  -4.410  1.00 64.69  ? 338 VAL A CA  1 
ATOM 2769 C C   . VAL A 1 344 ? 44.355 -3.068  -3.473  1.00 81.71  ? 338 VAL A C   1 
ATOM 2770 O O   . VAL A 1 344 ? 45.434 -2.667  -3.930  1.00 86.97  ? 338 VAL A O   1 
ATOM 2771 C CB  . VAL A 1 344 ? 42.988 -4.712  -4.830  1.00 69.27  ? 338 VAL A CB  1 
ATOM 2772 C CG1 . VAL A 1 344 ? 41.775 -4.873  -5.739  1.00 60.92  ? 338 VAL A CG1 1 
ATOM 2773 C CG2 . VAL A 1 344 ? 44.256 -5.261  -5.490  1.00 60.81  ? 338 VAL A CG2 1 
ATOM 2774 N N   . PRO A 1 345 ? 44.236 -3.365  -2.167  1.00 87.61  ? 339 PRO A N   1 
ATOM 2775 C CA  . PRO A 1 345 ? 45.381 -3.192  -1.253  1.00 90.78  ? 339 PRO A CA  1 
ATOM 2776 C C   . PRO A 1 345 ? 46.401 -4.323  -1.357  1.00 94.84  ? 339 PRO A C   1 
ATOM 2777 O O   . PRO A 1 345 ? 46.742 -4.994  -0.378  1.00 87.23  ? 339 PRO A O   1 
ATOM 2778 C CB  . PRO A 1 345 ? 44.688 -3.123  0.114   1.00 95.36  ? 339 PRO A CB  1 
ATOM 2779 C CG  . PRO A 1 345 ? 43.531 -4.054  -0.033  1.00 81.36  ? 339 PRO A CG  1 
ATOM 2780 C CD  . PRO A 1 345 ? 43.100 -4.014  -1.487  1.00 79.76  ? 339 PRO A CD  1 
ATOM 2781 N N   . ARG A 1 346 ? 46.908 -4.536  -2.574  1.00 97.63  ? 340 ARG A N   1 
ATOM 2782 C CA  . ARG A 1 346 ? 47.980 -5.494  -2.836  1.00 88.96  ? 340 ARG A CA  1 
ATOM 2783 C C   . ARG A 1 346 ? 49.190 -4.762  -3.410  1.00 97.26  ? 340 ARG A C   1 
ATOM 2784 O O   . ARG A 1 346 ? 49.768 -5.170  -4.425  1.00 101.26 ? 340 ARG A O   1 
ATOM 2785 C CB  . ARG A 1 346 ? 47.499 -6.606  -3.772  1.00 67.80  ? 340 ARG A CB  1 
ATOM 2786 C CG  . ARG A 1 346 ? 46.313 -7.358  -3.187  1.00 73.36  ? 340 ARG A CG  1 
ATOM 2787 C CD  . ARG A 1 346 ? 45.890 -8.542  -4.030  1.00 60.22  ? 340 ARG A CD  1 
ATOM 2788 N NE  . ARG A 1 346 ? 44.631 -9.111  -3.565  1.00 83.26  ? 340 ARG A NE  1 
ATOM 2789 C CZ  . ARG A 1 346 ? 44.038 -10.160 -4.120  1.00 80.19  ? 340 ARG A CZ  1 
ATOM 2790 N NH1 . ARG A 1 346 ? 44.567 -10.783 -5.160  1.00 66.19  ? 340 ARG A NH1 1 
ATOM 2791 N NH2 . ARG A 1 346 ? 42.886 -10.595 -3.619  1.00 81.34  ? 340 ARG A NH2 1 
ATOM 2792 N N   . TYR A 1 347 ? 49.569 -3.664  -2.756  1.00 114.38 ? 341 TYR A N   1 
ATOM 2793 C CA  . TYR A 1 347 ? 50.725 -2.848  -3.129  1.00 116.04 ? 341 TYR A CA  1 
ATOM 2794 C C   . TYR A 1 347 ? 52.037 -3.494  -2.709  1.00 112.78 ? 341 TYR A C   1 
ATOM 2795 O O   . TYR A 1 347 ? 52.941 -2.817  -2.212  1.00 113.50 ? 341 TYR A O   1 
ATOM 2796 C CB  . TYR A 1 347 ? 50.578 -1.464  -2.500  1.00 106.06 ? 341 TYR A CB  1 
ATOM 2797 C CG  . TYR A 1 347 ? 49.281 -0.776  -2.862  1.00 104.28 ? 341 TYR A CG  1 
ATOM 2798 C CD1 . TYR A 1 347 ? 48.961 -0.500  -4.182  1.00 109.09 ? 341 TYR A CD1 1 
ATOM 2799 C CD2 . TYR A 1 347 ? 48.367 -0.420  -1.878  1.00 99.20  ? 341 TYR A CD2 1 
ATOM 2800 C CE1 . TYR A 1 347 ? 47.771 0.122   -4.514  1.00 109.63 ? 341 TYR A CE1 1 
ATOM 2801 C CE2 . TYR A 1 347 ? 47.173 0.202   -2.197  1.00 110.37 ? 341 TYR A CE2 1 
ATOM 2802 C CZ  . TYR A 1 347 ? 46.878 0.471   -3.517  1.00 126.38 ? 341 TYR A CZ  1 
ATOM 2803 O OH  . TYR A 1 347 ? 45.691 1.091   -3.845  1.00 126.35 ? 341 TYR A OH  1 
ATOM 2804 N N   . SER A 1 348 ? 52.153 -4.811  -2.896  1.00 105.74 ? 342 SER A N   1 
ATOM 2805 C CA  . SER A 1 348 ? 53.282 -5.555  -2.347  1.00 136.38 ? 342 SER A CA  1 
ATOM 2806 C C   . SER A 1 348 ? 54.587 -5.168  -3.031  1.00 147.26 ? 342 SER A C   1 
ATOM 2807 O O   . SER A 1 348 ? 55.585 -4.871  -2.363  1.00 170.70 ? 342 SER A O   1 
ATOM 2808 C CB  . SER A 1 348 ? 53.030 -7.057  -2.490  1.00 128.50 ? 342 SER A CB  1 
ATOM 2809 O OG  . SER A 1 348 ? 51.919 -7.466  -1.714  1.00 133.36 ? 342 SER A OG  1 
ATOM 2810 N N   . GLU A 1 349 ? 54.600 -5.197  -4.367  1.00 118.75 ? 343 GLU A N   1 
ATOM 2811 C CA  . GLU A 1 349 ? 55.768 -4.904  -5.196  1.00 120.63 ? 343 GLU A CA  1 
ATOM 2812 C C   . GLU A 1 349 ? 56.875 -5.943  -5.032  1.00 138.53 ? 343 GLU A C   1 
ATOM 2813 O O   . GLU A 1 349 ? 57.778 -6.032  -5.872  1.00 143.76 ? 343 GLU A O   1 
ATOM 2814 C CB  . GLU A 1 349 ? 56.289 -3.493  -4.918  1.00 123.01 ? 343 GLU A CB  1 
ATOM 2815 C CG  . GLU A 1 349 ? 55.334 -2.406  -5.388  1.00 140.76 ? 343 GLU A CG  1 
ATOM 2816 C CD  . GLU A 1 349 ? 56.035 -1.099  -5.655  1.00 159.27 ? 343 GLU A CD  1 
ATOM 2817 O OE1 . GLU A 1 349 ? 57.280 -1.078  -5.564  1.00 160.42 ? 343 GLU A OE1 1 
ATOM 2818 O OE2 . GLU A 1 349 ? 55.342 -0.105  -5.965  1.00 169.70 ? 343 GLU A OE2 1 
ATOM 2819 N N   . SER A 1 350 ? 56.827 -6.727  -3.953  1.00 145.74 ? 344 SER A N   1 
ATOM 2820 C CA  . SER A 1 350 ? 57.478 -8.029  -3.978  1.00 143.51 ? 344 SER A CA  1 
ATOM 2821 C C   . SER A 1 350 ? 56.664 -9.005  -4.814  1.00 151.38 ? 344 SER A C   1 
ATOM 2822 O O   . SER A 1 350 ? 57.224 -9.935  -5.403  1.00 150.84 ? 344 SER A O   1 
ATOM 2823 C CB  . SER A 1 350 ? 57.672 -8.562  -2.556  1.00 119.03 ? 344 SER A CB  1 
ATOM 2824 O OG  . SER A 1 350 ? 56.471 -8.487  -1.805  1.00 119.90 ? 344 SER A OG  1 
ATOM 2825 N N   . GLN A 1 351 ? 55.349 -8.796  -4.870  1.00 143.47 ? 345 GLN A N   1 
ATOM 2826 C CA  . GLN A 1 351 ? 54.508 -9.416  -5.883  1.00 145.17 ? 345 GLN A CA  1 
ATOM 2827 C C   . GLN A 1 351 ? 54.959 -8.961  -7.267  1.00 134.33 ? 345 GLN A C   1 
ATOM 2828 O O   . GLN A 1 351 ? 55.518 -7.873  -7.437  1.00 139.61 ? 345 GLN A O   1 
ATOM 2829 C CB  . GLN A 1 351 ? 53.036 -9.048  -5.638  1.00 144.74 ? 345 GLN A CB  1 
ATOM 2830 C CG  . GLN A 1 351 ? 52.014 -9.460  -6.719  1.00 131.35 ? 345 GLN A CG  1 
ATOM 2831 C CD  . GLN A 1 351 ? 52.187 -10.877 -7.254  1.00 120.70 ? 345 GLN A CD  1 
ATOM 2832 O OE1 . GLN A 1 351 ? 52.626 -11.777 -6.542  1.00 140.89 ? 345 GLN A OE1 1 
ATOM 2833 N NE2 . GLN A 1 351 ? 51.862 -11.068 -8.531  1.00 91.37  ? 345 GLN A NE2 1 
ATOM 2834 N N   . LEU A 1 352 ? 54.720 -9.818  -8.256  1.00 109.67 ? 346 LEU A N   1 
ATOM 2835 C CA  . LEU A 1 352 ? 55.155 -9.572  -9.624  1.00 102.62 ? 346 LEU A CA  1 
ATOM 2836 C C   . LEU A 1 352 ? 54.732 -8.189  -10.105 1.00 111.81 ? 346 LEU A C   1 
ATOM 2837 O O   . LEU A 1 352 ? 53.577 -7.782  -9.941  1.00 122.93 ? 346 LEU A O   1 
ATOM 2838 C CB  . LEU A 1 352 ? 54.566 -10.643 -10.541 1.00 107.26 ? 346 LEU A CB  1 
ATOM 2839 C CG  . LEU A 1 352 ? 54.863 -12.069 -10.079 1.00 105.30 ? 346 LEU A CG  1 
ATOM 2840 C CD1 . LEU A 1 352 ? 53.947 -13.040 -10.778 1.00 97.03  ? 346 LEU A CD1 1 
ATOM 2841 C CD2 . LEU A 1 352 ? 56.313 -12.445 -10.293 1.00 88.65  ? 346 LEU A CD2 1 
ATOM 2842 N N   . LYS A 1 353 ? 55.681 -7.458  -10.684 1.00 106.97 ? 347 LYS A N   1 
ATOM 2843 C CA  . LYS A 1 353 ? 55.393 -6.175  -11.314 1.00 101.09 ? 347 LYS A CA  1 
ATOM 2844 C C   . LYS A 1 353 ? 55.007 -6.445  -12.762 1.00 88.75  ? 347 LYS A C   1 
ATOM 2845 O O   . LYS A 1 353 ? 55.831 -6.912  -13.557 1.00 90.25  ? 347 LYS A O   1 
ATOM 2846 C CB  . LYS A 1 353 ? 56.587 -5.230  -11.216 1.00 95.42  ? 347 LYS A CB  1 
ATOM 2847 C CG  . LYS A 1 353 ? 56.936 -4.838  -9.786  1.00 92.65  ? 347 LYS A CG  1 
ATOM 2848 C CD  . LYS A 1 353 ? 57.819 -3.602  -9.736  1.00 103.18 ? 347 LYS A CD  1 
ATOM 2849 C CE  . LYS A 1 353 ? 58.003 -3.113  -8.306  1.00 98.45  ? 347 LYS A CE  1 
ATOM 2850 N NZ  . LYS A 1 353 ? 58.722 -1.810  -8.244  1.00 101.82 ? 347 LYS A NZ  1 
ATOM 2851 N N   . VAL A 1 354 ? 53.749 -6.160  -13.097 1.00 49.59  ? 348 VAL A N   1 
ATOM 2852 C CA  . VAL A 1 354 ? 53.211 -6.551  -14.390 1.00 47.13  ? 348 VAL A CA  1 
ATOM 2853 C C   . VAL A 1 354 ? 53.852 -5.728  -15.501 1.00 64.48  ? 348 VAL A C   1 
ATOM 2854 O O   . VAL A 1 354 ? 54.285 -4.584  -15.302 1.00 84.29  ? 348 VAL A O   1 
ATOM 2855 C CB  . VAL A 1 354 ? 51.677 -6.403  -14.406 1.00 54.30  ? 348 VAL A CB  1 
ATOM 2856 C CG1 . VAL A 1 354 ? 51.276 -4.955  -14.639 1.00 69.37  ? 348 VAL A CG1 1 
ATOM 2857 C CG2 . VAL A 1 354 ? 51.062 -7.298  -15.469 1.00 53.80  ? 348 VAL A CG2 1 
ATOM 2858 N N   . ALA A 1 355 ? 53.932 -6.331  -16.682 1.00 48.85  ? 349 ALA A N   1 
ATOM 2859 C CA  . ALA A 1 355 ? 54.302 -5.646  -17.916 1.00 33.35  ? 349 ALA A CA  1 
ATOM 2860 C C   . ALA A 1 355 ? 53.178 -5.930  -18.904 1.00 35.82  ? 349 ALA A C   1 
ATOM 2861 O O   . ALA A 1 355 ? 53.144 -6.996  -19.526 1.00 43.81  ? 349 ALA A O   1 
ATOM 2862 C CB  . ALA A 1 355 ? 55.655 -6.121  -18.439 1.00 24.96  ? 349 ALA A CB  1 
ATOM 2863 N N   . LEU A 1 356 ? 52.244 -4.992  -19.026 1.00 26.71  ? 350 LEU A N   1 
ATOM 2864 C CA  . LEU A 1 356 ? 51.077 -5.169  -19.883 1.00 25.20  ? 350 LEU A CA  1 
ATOM 2865 C C   . LEU A 1 356 ? 51.414 -4.649  -21.277 1.00 31.69  ? 350 LEU A C   1 
ATOM 2866 O O   . LEU A 1 356 ? 51.450 -3.436  -21.506 1.00 29.77  ? 350 LEU A O   1 
ATOM 2867 C CB  . LEU A 1 356 ? 49.863 -4.450  -19.299 1.00 29.73  ? 350 LEU A CB  1 
ATOM 2868 C CG  . LEU A 1 356 ? 48.563 -4.513  -20.106 1.00 17.65  ? 350 LEU A CG  1 
ATOM 2869 C CD1 . LEU A 1 356 ? 48.224 -5.954  -20.477 1.00 16.23  ? 350 LEU A CD1 1 
ATOM 2870 C CD2 . LEU A 1 356 ? 47.417 -3.870  -19.346 1.00 18.59  ? 350 LEU A CD2 1 
ATOM 2871 N N   . VAL A 1 357 ? 51.652 -5.566  -22.205 1.00 55.20  ? 351 VAL A N   1 
ATOM 2872 C CA  . VAL A 1 357 ? 52.036 -5.244  -23.574 1.00 40.21  ? 351 VAL A CA  1 
ATOM 2873 C C   . VAL A 1 357 ? 50.781 -4.992  -24.394 1.00 40.63  ? 351 VAL A C   1 
ATOM 2874 O O   . VAL A 1 357 ? 49.784 -5.715  -24.270 1.00 43.46  ? 351 VAL A O   1 
ATOM 2875 C CB  . VAL A 1 357 ? 52.885 -6.378  -24.183 1.00 18.04  ? 351 VAL A CB  1 
ATOM 2876 C CG1 . VAL A 1 357 ? 53.291 -6.035  -25.603 1.00 27.27  ? 351 VAL A CG1 1 
ATOM 2877 C CG2 . VAL A 1 357 ? 54.110 -6.640  -23.319 1.00 13.90  ? 351 VAL A CG2 1 
ATOM 2878 N N   . GLU A 1 358 ? 50.830 -3.967  -25.244 1.00 34.42  ? 352 GLU A N   1 
ATOM 2879 C CA  . GLU A 1 358 ? 49.704 -3.576  -26.086 1.00 37.38  ? 352 GLU A CA  1 
ATOM 2880 C C   . GLU A 1 358 ? 49.931 -4.127  -27.490 1.00 51.02  ? 352 GLU A C   1 
ATOM 2881 O O   . GLU A 1 358 ? 50.846 -3.690  -28.194 1.00 46.81  ? 352 GLU A O   1 
ATOM 2882 C CB  . GLU A 1 358 ? 49.552 -2.057  -26.107 1.00 42.61  ? 352 GLU A CB  1 
ATOM 2883 C CG  . GLU A 1 358 ? 49.480 -1.439  -24.722 1.00 48.21  ? 352 GLU A CG  1 
ATOM 2884 C CD  . GLU A 1 358 ? 48.944 -0.024  -24.736 1.00 57.62  ? 352 GLU A CD  1 
ATOM 2885 O OE1 . GLU A 1 358 ? 48.564 0.469   -25.819 1.00 79.91  ? 352 GLU A OE1 1 
ATOM 2886 O OE2 . GLU A 1 358 ? 48.901 0.597   -23.655 1.00 55.04  ? 352 GLU A OE2 1 
ATOM 2887 N N   . VAL A 1 359 ? 49.099 -5.084  -27.895 1.00 49.20  ? 353 VAL A N   1 
ATOM 2888 C CA  . VAL A 1 359 ? 49.222 -5.711  -29.207 1.00 34.06  ? 353 VAL A CA  1 
ATOM 2889 C C   . VAL A 1 359 ? 48.528 -4.823  -30.234 1.00 40.44  ? 353 VAL A C   1 
ATOM 2890 O O   . VAL A 1 359 ? 47.305 -4.667  -30.212 1.00 46.20  ? 353 VAL A O   1 
ATOM 2891 C CB  . VAL A 1 359 ? 48.636 -7.127  -29.213 1.00 37.94  ? 353 VAL A CB  1 
ATOM 2892 C CG1 . VAL A 1 359 ? 48.858 -7.778  -30.563 1.00 36.69  ? 353 VAL A CG1 1 
ATOM 2893 C CG2 . VAL A 1 359 ? 49.270 -7.966  -28.117 1.00 42.91  ? 353 VAL A CG2 1 
ATOM 2894 N N   . GLU A 1 360 ? 49.308 -4.249  -31.141 1.00 45.09  ? 354 GLU A N   1 
ATOM 2895 C CA  . GLU A 1 360 ? 48.761 -3.355  -32.144 1.00 51.41  ? 354 GLU A CA  1 
ATOM 2896 C C   . GLU A 1 360 ? 48.212 -4.153  -33.325 1.00 53.58  ? 354 GLU A C   1 
ATOM 2897 O O   . GLU A 1 360 ? 48.409 -5.366  -33.439 1.00 52.16  ? 354 GLU A O   1 
ATOM 2898 C CB  . GLU A 1 360 ? 49.824 -2.350  -32.579 1.00 53.03  ? 354 GLU A CB  1 
ATOM 2899 C CG  . GLU A 1 360 ? 50.129 -1.336  -31.484 1.00 66.27  ? 354 GLU A CG  1 
ATOM 2900 C CD  . GLU A 1 360 ? 51.508 -0.719  -31.604 1.00 86.44  ? 354 GLU A CD  1 
ATOM 2901 O OE1 . GLU A 1 360 ? 51.797 -0.103  -32.651 1.00 92.18  ? 354 GLU A OE1 1 
ATOM 2902 O OE2 . GLU A 1 360 ? 52.302 -0.849  -30.646 1.00 81.98  ? 354 GLU A OE2 1 
ATOM 2903 N N   . GLU A 1 361 ? 47.521 -3.446  -34.223 1.00 58.56  ? 355 GLU A N   1 
ATOM 2904 C CA  . GLU A 1 361 ? 46.738 -4.117  -35.259 1.00 54.53  ? 355 GLU A CA  1 
ATOM 2905 C C   . GLU A 1 361 ? 47.620 -4.909  -36.221 1.00 65.46  ? 355 GLU A C   1 
ATOM 2906 O O   . GLU A 1 361 ? 47.308 -6.060  -36.549 1.00 67.56  ? 355 GLU A O   1 
ATOM 2907 C CB  . GLU A 1 361 ? 45.888 -3.099  -36.015 1.00 53.53  ? 355 GLU A CB  1 
ATOM 2908 C CG  . GLU A 1 361 ? 45.439 -1.918  -35.177 1.00 57.17  ? 355 GLU A CG  1 
ATOM 2909 C CD  . GLU A 1 361 ? 44.516 -2.324  -34.047 1.00 74.30  ? 355 GLU A CD  1 
ATOM 2910 O OE1 . GLU A 1 361 ? 43.410 -2.832  -34.338 1.00 62.44  ? 355 GLU A OE1 1 
ATOM 2911 O OE2 . GLU A 1 361 ? 44.892 -2.128  -32.872 1.00 87.34  ? 355 GLU A OE2 1 
ATOM 2912 N N   . ARG A 1 362 ? 48.729 -4.321  -36.681 1.00 60.47  ? 356 ARG A N   1 
ATOM 2913 C CA  . ARG A 1 362 ? 49.621 -5.051  -37.579 1.00 60.88  ? 356 ARG A CA  1 
ATOM 2914 C C   . ARG A 1 362 ? 50.160 -6.316  -36.922 1.00 64.20  ? 356 ARG A C   1 
ATOM 2915 O O   . ARG A 1 362 ? 50.545 -7.260  -37.623 1.00 54.27  ? 356 ARG A O   1 
ATOM 2916 C CB  . ARG A 1 362 ? 50.794 -4.170  -38.009 1.00 56.53  ? 356 ARG A CB  1 
ATOM 2917 C CG  . ARG A 1 362 ? 51.626 -3.705  -36.834 1.00 69.99  ? 356 ARG A CG  1 
ATOM 2918 C CD  . ARG A 1 362 ? 52.861 -2.929  -37.251 1.00 59.30  ? 356 ARG A CD  1 
ATOM 2919 N NE  . ARG A 1 362 ? 53.799 -2.800  -36.141 1.00 88.73  ? 356 ARG A NE  1 
ATOM 2920 C CZ  . ARG A 1 362 ? 53.605 -2.049  -35.066 1.00 90.94  ? 356 ARG A CZ  1 
ATOM 2921 N NH1 . ARG A 1 362 ? 52.495 -1.349  -34.899 1.00 99.23  ? 356 ARG A NH1 1 
ATOM 2922 N NH2 . ARG A 1 362 ? 54.546 -2.009  -34.125 1.00 86.12  ? 356 ARG A NH2 1 
ATOM 2923 N N   . GLU A 1 363 ? 50.188 -6.352  -35.587 1.00 69.79  ? 357 GLU A N   1 
ATOM 2924 C CA  . GLU A 1 363 ? 50.668 -7.504  -34.838 1.00 58.61  ? 357 GLU A CA  1 
ATOM 2925 C C   . GLU A 1 363 ? 49.556 -8.477  -34.467 1.00 43.93  ? 357 GLU A C   1 
ATOM 2926 O O   . GLU A 1 363 ? 49.850 -9.621  -34.104 1.00 37.99  ? 357 GLU A O   1 
ATOM 2927 C CB  . GLU A 1 363 ? 51.370 -7.041  -33.557 1.00 67.97  ? 357 GLU A CB  1 
ATOM 2928 C CG  . GLU A 1 363 ? 52.542 -6.101  -33.781 1.00 70.72  ? 357 GLU A CG  1 
ATOM 2929 C CD  . GLU A 1 363 ? 53.603 -6.691  -34.686 1.00 102.38 ? 357 GLU A CD  1 
ATOM 2930 O OE1 . GLU A 1 363 ? 54.185 -7.736  -34.327 1.00 108.26 ? 357 GLU A OE1 1 
ATOM 2931 O OE2 . GLU A 1 363 ? 53.853 -6.104  -35.760 1.00 100.50 ? 357 GLU A OE2 1 
ATOM 2932 N N   . LEU A 1 364 ? 48.297 -8.047  -34.548 1.00 42.84  ? 358 LEU A N   1 
ATOM 2933 C CA  . LEU A 1 364 ? 47.191 -8.888  -34.095 1.00 43.62  ? 358 LEU A CA  1 
ATOM 2934 C C   . LEU A 1 364 ? 47.066 -10.199 -34.865 1.00 41.59  ? 358 LEU A C   1 
ATOM 2935 O O   . LEU A 1 364 ? 46.841 -11.239 -34.216 1.00 40.86  ? 358 LEU A O   1 
ATOM 2936 C CB  . LEU A 1 364 ? 45.882 -8.087  -34.154 1.00 40.60  ? 358 LEU A CB  1 
ATOM 2937 C CG  . LEU A 1 364 ? 45.563 -7.195  -32.953 1.00 48.66  ? 358 LEU A CG  1 
ATOM 2938 C CD1 . LEU A 1 364 ? 44.356 -6.315  -33.240 1.00 45.30  ? 358 LEU A CD1 1 
ATOM 2939 C CD2 . LEU A 1 364 ? 45.328 -8.034  -31.707 1.00 47.35  ? 358 LEU A CD2 1 
ATOM 2940 N N   . PRO A 1 365 ? 47.171 -10.244 -36.201 1.00 41.71  ? 359 PRO A N   1 
ATOM 2941 C CA  . PRO A 1 365 ? 47.192 -11.554 -36.874 1.00 32.84  ? 359 PRO A CA  1 
ATOM 2942 C C   . PRO A 1 365 ? 48.340 -12.438 -36.421 1.00 27.28  ? 359 PRO A C   1 
ATOM 2943 O O   . PRO A 1 365 ? 48.152 -13.646 -36.233 1.00 25.04  ? 359 PRO A O   1 
ATOM 2944 C CB  . PRO A 1 365 ? 47.314 -11.178 -38.355 1.00 40.79  ? 359 PRO A CB  1 
ATOM 2945 C CG  . PRO A 1 365 ? 46.684 -9.845  -38.446 1.00 41.46  ? 359 PRO A CG  1 
ATOM 2946 C CD  . PRO A 1 365 ? 47.060 -9.143  -37.178 1.00 42.96  ? 359 PRO A CD  1 
ATOM 2947 N N   . LYS A 1 366 ? 49.532 -11.863 -36.250 1.00 29.51  ? 360 LYS A N   1 
ATOM 2948 C CA  . LYS A 1 366 ? 50.662 -12.630 -35.736 1.00 36.02  ? 360 LYS A CA  1 
ATOM 2949 C C   . LYS A 1 366 ? 50.364 -13.171 -34.344 1.00 48.13  ? 360 LYS A C   1 
ATOM 2950 O O   . LYS A 1 366 ? 50.622 -14.345 -34.054 1.00 50.62  ? 360 LYS A O   1 
ATOM 2951 C CB  . LYS A 1 366 ? 51.911 -11.750 -35.699 1.00 50.55  ? 360 LYS A CB  1 
ATOM 2952 C CG  . LYS A 1 366 ? 52.245 -11.068 -37.014 1.00 43.49  ? 360 LYS A CG  1 
ATOM 2953 C CD  . LYS A 1 366 ? 53.479 -10.194 -36.854 1.00 75.31  ? 360 LYS A CD  1 
ATOM 2954 C CE  . LYS A 1 366 ? 53.776 -9.384  -38.104 1.00 92.28  ? 360 LYS A CE  1 
ATOM 2955 N NZ  . LYS A 1 366 ? 54.906 -8.436  -37.878 1.00 99.47  ? 360 LYS A NZ  1 
ATOM 2956 N N   . TRP A 1 367 ? 49.801 -12.327 -33.478 1.00 43.03  ? 361 TRP A N   1 
ATOM 2957 C CA  . TRP A 1 367 ? 49.605 -12.679 -32.076 1.00 42.04  ? 361 TRP A CA  1 
ATOM 2958 C C   . TRP A 1 367 ? 48.494 -13.705 -31.887 1.00 46.20  ? 361 TRP A C   1 
ATOM 2959 O O   . TRP A 1 367 ? 48.553 -14.511 -30.952 1.00 39.07  ? 361 TRP A O   1 
ATOM 2960 C CB  . TRP A 1 367 ? 49.332 -11.401 -31.280 1.00 53.18  ? 361 TRP A CB  1 
ATOM 2961 C CG  . TRP A 1 367 ? 49.010 -11.604 -29.839 1.00 46.01  ? 361 TRP A CG  1 
ATOM 2962 C CD1 . TRP A 1 367 ? 49.893 -11.881 -28.836 1.00 44.71  ? 361 TRP A CD1 1 
ATOM 2963 C CD2 . TRP A 1 367 ? 47.725 -11.475 -29.220 1.00 36.08  ? 361 TRP A CD2 1 
ATOM 2964 N NE1 . TRP A 1 367 ? 49.232 -11.972 -27.638 1.00 40.43  ? 361 TRP A NE1 1 
ATOM 2965 C CE2 . TRP A 1 367 ? 47.900 -11.722 -27.845 1.00 35.22  ? 361 TRP A CE2 1 
ATOM 2966 C CE3 . TRP A 1 367 ? 46.443 -11.190 -29.697 1.00 33.97  ? 361 TRP A CE3 1 
ATOM 2967 C CZ2 . TRP A 1 367 ? 46.840 -11.692 -26.940 1.00 38.41  ? 361 TRP A CZ2 1 
ATOM 2968 C CZ3 . TRP A 1 367 ? 45.391 -11.162 -28.796 1.00 37.69  ? 361 TRP A CZ3 1 
ATOM 2969 C CH2 . TRP A 1 367 ? 45.597 -11.411 -27.434 1.00 25.49  ? 361 TRP A CH2 1 
ATOM 2970 N N   . LEU A 1 368 ? 47.481 -13.694 -32.753 1.00 56.83  ? 362 LEU A N   1 
ATOM 2971 C CA  . LEU A 1 368 ? 46.445 -14.717 -32.713 1.00 53.20  ? 362 LEU A CA  1 
ATOM 2972 C C   . LEU A 1 368 ? 46.887 -16.028 -33.351 1.00 48.86  ? 362 LEU A C   1 
ATOM 2973 O O   . LEU A 1 368 ? 46.184 -17.035 -33.211 1.00 58.91  ? 362 LEU A O   1 
ATOM 2974 C CB  . LEU A 1 368 ? 45.172 -14.200 -33.392 1.00 48.65  ? 362 LEU A CB  1 
ATOM 2975 C CG  . LEU A 1 368 ? 44.468 -13.038 -32.680 1.00 42.48  ? 362 LEU A CG  1 
ATOM 2976 C CD1 . LEU A 1 368 ? 43.467 -12.352 -33.595 1.00 43.48  ? 362 LEU A CD1 1 
ATOM 2977 C CD2 . LEU A 1 368 ? 43.783 -13.520 -31.406 1.00 46.01  ? 362 LEU A CD2 1 
ATOM 2978 N N   . ALA A 1 369 ? 48.028 -16.039 -34.042 1.00 59.41  ? 363 ALA A N   1 
ATOM 2979 C CA  . ALA A 1 369 ? 48.638 -17.264 -34.542 1.00 63.26  ? 363 ALA A CA  1 
ATOM 2980 C C   . ALA A 1 369 ? 49.918 -17.618 -33.799 1.00 61.78  ? 363 ALA A C   1 
ATOM 2981 O O   . ALA A 1 369 ? 50.629 -18.543 -34.212 1.00 51.27  ? 363 ALA A O   1 
ATOM 2982 C CB  . ALA A 1 369 ? 48.929 -17.147 -36.041 1.00 63.23  ? 363 ALA A CB  1 
ATOM 2983 N N   . GLU A 1 370 ? 50.239 -16.900 -32.723 1.00 65.40  ? 364 GLU A N   1 
ATOM 2984 C CA  . GLU A 1 370 ? 51.393 -17.232 -31.896 1.00 70.85  ? 364 GLU A CA  1 
ATOM 2985 C C   . GLU A 1 370 ? 50.950 -18.180 -30.790 1.00 76.74  ? 364 GLU A C   1 
ATOM 2986 O O   . GLU A 1 370 ? 51.504 -18.161 -29.688 1.00 102.03 ? 364 GLU A O   1 
ATOM 2987 C CB  . GLU A 1 370 ? 52.025 -15.967 -31.302 1.00 71.77  ? 364 GLU A CB  1 
ATOM 2988 C CG  . GLU A 1 370 ? 53.073 -15.309 -32.195 1.00 74.95  ? 364 GLU A CG  1 
ATOM 2989 C CD  . GLU A 1 370 ? 53.368 -13.883 -31.770 1.00 74.80  ? 364 GLU A CD  1 
ATOM 2990 O OE1 . GLU A 1 370 ? 52.922 -13.486 -30.675 1.00 81.96  ? 364 GLU A OE1 1 
ATOM 2991 O OE2 . GLU A 1 370 ? 54.012 -13.145 -32.543 1.00 74.22  ? 364 GLU A OE2 1 
ATOM 2992 N N   . LYS A 1 371 ? 49.953 -19.017 -31.079 1.00 76.12  ? 365 LYS A N   1 
ATOM 2993 C CA  . LYS A 1 371 ? 49.314 -19.871 -30.075 1.00 93.05  ? 365 LYS A CA  1 
ATOM 2994 C C   . LYS A 1 371 ? 49.965 -21.251 -30.128 1.00 92.43  ? 365 LYS A C   1 
ATOM 2995 O O   . LYS A 1 371 ? 49.487 -22.162 -30.804 1.00 82.48  ? 365 LYS A O   1 
ATOM 2996 C CB  . LYS A 1 371 ? 47.811 -19.958 -30.326 1.00 96.24  ? 365 LYS A CB  1 
ATOM 2997 C CG  . LYS A 1 371 ? 47.078 -18.629 -30.235 1.00 82.83  ? 365 LYS A CG  1 
ATOM 2998 C CD  . LYS A 1 371 ? 45.611 -18.786 -30.603 1.00 72.30  ? 365 LYS A CD  1 
ATOM 2999 C CE  . LYS A 1 371 ? 44.889 -19.645 -29.580 1.00 98.61  ? 365 LYS A CE  1 
ATOM 3000 N NZ  . LYS A 1 371 ? 43.423 -19.382 -29.558 1.00 82.70  ? 365 LYS A NZ  1 
ATOM 3001 N N   . ASP A 1 372 ? 51.069 -21.420 -29.393 1.00 90.13  ? 366 ASP A N   1 
ATOM 3002 C CA  . ASP A 1 372 ? 51.803 -22.688 -29.364 1.00 105.88 ? 366 ASP A CA  1 
ATOM 3003 C C   . ASP A 1 372 ? 52.296 -22.908 -27.929 1.00 103.09 ? 366 ASP A C   1 
ATOM 3004 O O   . ASP A 1 372 ? 53.483 -23.004 -27.638 1.00 108.29 ? 366 ASP A O   1 
ATOM 3005 C CB  . ASP A 1 372 ? 52.944 -22.679 -30.386 1.00 114.13 ? 366 ASP A CB  1 
ATOM 3006 C CG  . ASP A 1 372 ? 53.683 -24.004 -30.470 1.00 124.31 ? 366 ASP A CG  1 
ATOM 3007 O OD1 . ASP A 1 372 ? 53.232 -24.989 -29.849 1.00 137.06 ? 366 ASP A OD1 1 
ATOM 3008 O OD2 . ASP A 1 372 ? 54.719 -24.058 -31.169 1.00 108.79 ? 366 ASP A OD2 1 
ATOM 3009 N N   . GLU A 1 373 ? 51.353 -23.028 -26.995 1.00 79.40  ? 367 GLU A N   1 
ATOM 3010 C CA  . GLU A 1 373 ? 51.672 -22.924 -25.578 1.00 76.39  ? 367 GLU A CA  1 
ATOM 3011 C C   . GLU A 1 373 ? 50.819 -23.901 -24.777 1.00 75.44  ? 367 GLU A C   1 
ATOM 3012 O O   . GLU A 1 373 ? 49.904 -24.538 -25.304 1.00 68.81  ? 367 GLU A O   1 
ATOM 3013 C CB  . GLU A 1 373 ? 51.468 -21.483 -25.102 1.00 81.96  ? 367 GLU A CB  1 
ATOM 3014 C CG  . GLU A 1 373 ? 50.030 -21.013 -25.249 1.00 85.34  ? 367 GLU A CG  1 
ATOM 3015 C CD  . GLU A 1 373 ? 49.898 -19.501 -25.301 1.00 88.49  ? 367 GLU A CD  1 
ATOM 3016 O OE1 . GLU A 1 373 ? 50.396 -18.808 -24.389 1.00 99.57  ? 367 GLU A OE1 1 
ATOM 3017 O OE2 . GLU A 1 373 ? 49.294 -19.002 -26.274 1.00 75.36  ? 367 GLU A OE2 1 
ATOM 3018 N N   . TYR A 1 374 ? 51.139 -24.020 -23.483 1.00 81.85  ? 368 TYR A N   1 
ATOM 3019 C CA  . TYR A 1 374 ? 50.372 -24.890 -22.597 1.00 68.57  ? 368 TYR A CA  1 
ATOM 3020 C C   . TYR A 1 374 ? 49.039 -24.262 -22.214 1.00 71.33  ? 368 TYR A C   1 
ATOM 3021 O O   . TYR A 1 374 ? 48.058 -24.982 -21.982 1.00 85.32  ? 368 TYR A O   1 
ATOM 3022 C CB  . TYR A 1 374 ? 51.186 -25.220 -21.340 1.00 62.01  ? 368 TYR A CB  1 
ATOM 3023 C CG  . TYR A 1 374 ? 52.554 -25.801 -21.636 1.00 108.57 ? 368 TYR A CG  1 
ATOM 3024 C CD1 . TYR A 1 374 ? 52.689 -26.970 -22.374 1.00 125.80 ? 368 TYR A CD1 1 
ATOM 3025 C CD2 . TYR A 1 374 ? 53.711 -25.183 -21.170 1.00 103.61 ? 368 TYR A CD2 1 
ATOM 3026 C CE1 . TYR A 1 374 ? 53.942 -27.508 -22.651 1.00 128.72 ? 368 TYR A CE1 1 
ATOM 3027 C CE2 . TYR A 1 374 ? 54.968 -25.713 -21.439 1.00 101.33 ? 368 TYR A CE2 1 
ATOM 3028 C CZ  . TYR A 1 374 ? 55.078 -26.875 -22.180 1.00 123.79 ? 368 TYR A CZ  1 
ATOM 3029 O OH  . TYR A 1 374 ? 56.326 -27.401 -22.447 1.00 126.32 ? 368 TYR A OH  1 
ATOM 3030 N N   . GLY A 1 375 ? 48.988 -22.928 -22.148 1.00 48.59  ? 369 GLY A N   1 
ATOM 3031 C CA  . GLY A 1 375 ? 47.729 -22.247 -21.914 1.00 41.86  ? 369 GLY A CA  1 
ATOM 3032 C C   . GLY A 1 375 ? 46.686 -22.558 -22.964 1.00 44.69  ? 369 GLY A C   1 
ATOM 3033 O O   . GLY A 1 375 ? 45.491 -22.561 -22.669 1.00 56.29  ? 369 GLY A O   1 
ATOM 3034 N N   . TRP A 1 376 ? 47.120 -22.839 -24.196 1.00 47.91  ? 370 TRP A N   1 
ATOM 3035 C CA  . TRP A 1 376 ? 46.186 -23.248 -25.238 1.00 59.93  ? 370 TRP A CA  1 
ATOM 3036 C C   . TRP A 1 376 ? 45.447 -24.517 -24.831 1.00 63.71  ? 370 TRP A C   1 
ATOM 3037 O O   . TRP A 1 376 ? 44.214 -24.567 -24.866 1.00 64.64  ? 370 TRP A O   1 
ATOM 3038 C CB  . TRP A 1 376 ? 46.936 -23.459 -26.554 1.00 60.53  ? 370 TRP A CB  1 
ATOM 3039 C CG  . TRP A 1 376 ? 46.052 -23.804 -27.709 1.00 76.74  ? 370 TRP A CG  1 
ATOM 3040 C CD1 . TRP A 1 376 ? 45.507 -22.936 -28.602 1.00 84.27  ? 370 TRP A CD1 1 
ATOM 3041 C CD2 . TRP A 1 376 ? 45.598 -25.111 -28.089 1.00 86.07  ? 370 TRP A CD2 1 
ATOM 3042 N NE1 . TRP A 1 376 ? 44.747 -23.617 -29.524 1.00 93.43  ? 370 TRP A NE1 1 
ATOM 3043 C CE2 . TRP A 1 376 ? 44.787 -24.954 -29.231 1.00 91.19  ? 370 TRP A CE2 1 
ATOM 3044 C CE3 . TRP A 1 376 ? 45.803 -26.397 -27.578 1.00 73.18  ? 370 TRP A CE3 1 
ATOM 3045 C CZ2 . TRP A 1 376 ? 44.180 -26.032 -29.869 1.00 89.62  ? 370 TRP A CZ2 1 
ATOM 3046 C CZ3 . TRP A 1 376 ? 45.200 -27.467 -28.212 1.00 66.48  ? 370 TRP A CZ3 1 
ATOM 3047 C CH2 . TRP A 1 376 ? 44.398 -27.279 -29.346 1.00 87.59  ? 370 TRP A CH2 1 
ATOM 3048 N N   . ASN A 1 377 ? 46.195 -25.555 -24.441 1.00 61.53  ? 371 ASN A N   1 
ATOM 3049 C CA  . ASN A 1 377 ? 45.588 -26.798 -23.971 1.00 47.75  ? 371 ASN A CA  1 
ATOM 3050 C C   . ASN A 1 377 ? 44.719 -26.557 -22.747 1.00 48.91  ? 371 ASN A C   1 
ATOM 3051 O O   . ASN A 1 377 ? 43.616 -27.106 -22.635 1.00 55.32  ? 371 ASN A O   1 
ATOM 3052 C CB  . ASN A 1 377 ? 46.674 -27.822 -23.640 1.00 40.76  ? 371 ASN A CB  1 
ATOM 3053 C CG  . ASN A 1 377 ? 47.457 -28.246 -24.853 1.00 82.52  ? 371 ASN A CG  1 
ATOM 3054 O OD1 . ASN A 1 377 ? 47.118 -29.226 -25.513 1.00 96.25  ? 371 ASN A OD1 1 
ATOM 3055 N ND2 . ASN A 1 377 ? 48.513 -27.503 -25.161 1.00 90.62  ? 371 ASN A ND2 1 
ATOM 3056 N N   . VAL A 1 378 ? 45.214 -25.745 -21.808 1.00 46.80  ? 372 VAL A N   1 
ATOM 3057 C CA  . VAL A 1 378 ? 44.464 -25.468 -20.584 1.00 43.50  ? 372 VAL A CA  1 
ATOM 3058 C C   . VAL A 1 378 ? 43.095 -24.893 -20.917 1.00 45.58  ? 372 VAL A C   1 
ATOM 3059 O O   . VAL A 1 378 ? 42.062 -25.403 -20.469 1.00 47.99  ? 372 VAL A O   1 
ATOM 3060 C CB  . VAL A 1 378 ? 45.260 -24.521 -19.668 1.00 37.61  ? 372 VAL A CB  1 
ATOM 3061 C CG1 . VAL A 1 378 ? 44.360 -23.958 -18.569 1.00 52.22  ? 372 VAL A CG1 1 
ATOM 3062 C CG2 . VAL A 1 378 ? 46.464 -25.238 -19.078 1.00 30.81  ? 372 VAL A CG2 1 
ATOM 3063 N N   . VAL A 1 379 ? 43.068 -23.837 -21.731 1.00 41.39  ? 373 VAL A N   1 
ATOM 3064 C CA  . VAL A 1 379 ? 41.814 -23.157 -22.034 1.00 45.61  ? 373 VAL A CA  1 
ATOM 3065 C C   . VAL A 1 379 ? 40.922 -24.024 -22.914 1.00 52.49  ? 373 VAL A C   1 
ATOM 3066 O O   . VAL A 1 379 ? 39.697 -24.032 -22.751 1.00 57.45  ? 373 VAL A O   1 
ATOM 3067 C CB  . VAL A 1 379 ? 42.097 -21.790 -22.679 1.00 48.13  ? 373 VAL A CB  1 
ATOM 3068 C CG1 . VAL A 1 379 ? 40.795 -21.099 -23.053 1.00 37.79  ? 373 VAL A CG1 1 
ATOM 3069 C CG2 . VAL A 1 379 ? 42.905 -20.929 -21.731 1.00 61.78  ? 373 VAL A CG2 1 
ATOM 3070 N N   . GLU A 1 380 ? 41.509 -24.768 -23.855 1.00 50.29  ? 374 GLU A N   1 
ATOM 3071 C CA  . GLU A 1 380 ? 40.709 -25.637 -24.713 1.00 52.29  ? 374 GLU A CA  1 
ATOM 3072 C C   . GLU A 1 380 ? 39.989 -26.694 -23.881 1.00 42.72  ? 374 GLU A C   1 
ATOM 3073 O O   . GLU A 1 380 ? 38.773 -26.894 -24.013 1.00 27.41  ? 374 GLU A O   1 
ATOM 3074 C CB  . GLU A 1 380 ? 41.610 -26.290 -25.766 1.00 61.90  ? 374 GLU A CB  1 
ATOM 3075 C CG  . GLU A 1 380 ? 40.888 -27.034 -26.874 1.00 79.21  ? 374 GLU A CG  1 
ATOM 3076 C CD  . GLU A 1 380 ? 40.019 -26.120 -27.721 1.00 86.86  ? 374 GLU A CD  1 
ATOM 3077 O OE1 . GLU A 1 380 ? 40.581 -25.253 -28.427 1.00 61.96  ? 374 GLU A OE1 1 
ATOM 3078 O OE2 . GLU A 1 380 ? 38.781 -26.266 -27.681 1.00 82.70  ? 374 GLU A OE2 1 
ATOM 3079 N N   . LYS A 1 381 ? 40.724 -27.358 -22.986 1.00 51.17  ? 375 LYS A N   1 
ATOM 3080 C CA  . LYS A 1 381 ? 40.125 -28.388 -22.147 1.00 53.84  ? 375 LYS A CA  1 
ATOM 3081 C C   . LYS A 1 381 ? 39.170 -27.794 -21.118 1.00 41.86  ? 375 LYS A C   1 
ATOM 3082 O O   . LYS A 1 381 ? 38.193 -28.447 -20.731 1.00 39.91  ? 375 LYS A O   1 
ATOM 3083 C CB  . LYS A 1 381 ? 41.227 -29.193 -21.463 1.00 52.44  ? 375 LYS A CB  1 
ATOM 3084 C CG  . LYS A 1 381 ? 42.038 -30.026 -22.438 1.00 74.67  ? 375 LYS A CG  1 
ATOM 3085 C CD  . LYS A 1 381 ? 43.212 -30.704 -21.760 1.00 70.91  ? 375 LYS A CD  1 
ATOM 3086 C CE  . LYS A 1 381 ? 44.051 -31.488 -22.754 1.00 63.04  ? 375 LYS A CE  1 
ATOM 3087 N NZ  . LYS A 1 381 ? 45.196 -32.176 -22.098 1.00 60.80  ? 375 LYS A NZ  1 
ATOM 3088 N N   . PHE A 1 382 ? 39.433 -26.563 -20.668 1.00 43.47  ? 376 PHE A N   1 
ATOM 3089 C CA  . PHE A 1 382 ? 38.475 -25.857 -19.826 1.00 47.81  ? 376 PHE A CA  1 
ATOM 3090 C C   . PHE A 1 382 ? 37.162 -25.625 -20.560 1.00 51.55  ? 376 PHE A C   1 
ATOM 3091 O O   . PHE A 1 382 ? 36.083 -25.805 -19.987 1.00 56.63  ? 376 PHE A O   1 
ATOM 3092 C CB  . PHE A 1 382 ? 39.068 -24.527 -19.360 1.00 46.20  ? 376 PHE A CB  1 
ATOM 3093 C CG  . PHE A 1 382 ? 38.104 -23.678 -18.585 1.00 50.05  ? 376 PHE A CG  1 
ATOM 3094 C CD1 . PHE A 1 382 ? 37.729 -24.032 -17.301 1.00 53.01  ? 376 PHE A CD1 1 
ATOM 3095 C CD2 . PHE A 1 382 ? 37.557 -22.536 -19.150 1.00 47.04  ? 376 PHE A CD2 1 
ATOM 3096 C CE1 . PHE A 1 382 ? 36.834 -23.257 -16.588 1.00 56.26  ? 376 PHE A CE1 1 
ATOM 3097 C CE2 . PHE A 1 382 ? 36.660 -21.757 -18.443 1.00 52.29  ? 376 PHE A CE2 1 
ATOM 3098 C CZ  . PHE A 1 382 ? 36.298 -22.119 -17.159 1.00 55.06  ? 376 PHE A CZ  1 
ATOM 3099 N N   . VAL A 1 383 ? 37.234 -25.226 -21.832 1.00 54.31  ? 377 VAL A N   1 
ATOM 3100 C CA  . VAL A 1 383 ? 36.017 -25.017 -22.610 1.00 45.46  ? 377 VAL A CA  1 
ATOM 3101 C C   . VAL A 1 383 ? 35.286 -26.333 -22.821 1.00 50.96  ? 377 VAL A C   1 
ATOM 3102 O O   . VAL A 1 383 ? 34.050 -26.373 -22.817 1.00 52.33  ? 377 VAL A O   1 
ATOM 3103 C CB  . VAL A 1 383 ? 36.348 -24.327 -23.948 1.00 36.65  ? 377 VAL A CB  1 
ATOM 3104 C CG1 . VAL A 1 383 ? 35.135 -24.328 -24.868 1.00 69.12  ? 377 VAL A CG1 1 
ATOM 3105 C CG2 . VAL A 1 383 ? 36.821 -22.904 -23.696 1.00 38.74  ? 377 VAL A CG2 1 
ATOM 3106 N N   . GLU A 1 384 ? 36.022 -27.430 -22.998 1.00 58.35  ? 378 GLU A N   1 
ATOM 3107 C CA  . GLU A 1 384 ? 35.350 -28.716 -23.182 1.00 58.10  ? 378 GLU A CA  1 
ATOM 3108 C C   . GLU A 1 384 ? 34.652 -29.177 -21.909 1.00 50.32  ? 378 GLU A C   1 
ATOM 3109 O O   . GLU A 1 384 ? 33.483 -29.576 -21.947 1.00 56.42  ? 378 GLU A O   1 
ATOM 3110 C CB  . GLU A 1 384 ? 36.324 -29.776 -23.681 1.00 58.21  ? 378 GLU A CB  1 
ATOM 3111 C CG  . GLU A 1 384 ? 36.672 -29.586 -25.133 1.00 89.62  ? 378 GLU A CG  1 
ATOM 3112 C CD  . GLU A 1 384 ? 37.787 -30.480 -25.577 1.00 106.13 ? 378 GLU A CD  1 
ATOM 3113 O OE1 . GLU A 1 384 ? 38.287 -31.264 -24.741 1.00 97.43  ? 378 GLU A OE1 1 
ATOM 3114 O OE2 . GLU A 1 384 ? 38.128 -30.423 -26.775 1.00 102.71 ? 378 GLU A OE2 1 
ATOM 3115 N N   . THR A 1 385 ? 35.347 -29.140 -20.771 1.00 40.88  ? 379 THR A N   1 
ATOM 3116 C CA  . THR A 1 385 ? 34.670 -29.486 -19.525 1.00 43.97  ? 379 THR A CA  1 
ATOM 3117 C C   . THR A 1 385 ? 33.556 -28.499 -19.194 1.00 43.59  ? 379 THR A C   1 
ATOM 3118 O O   . THR A 1 385 ? 32.636 -28.844 -18.444 1.00 50.49  ? 379 THR A O   1 
ATOM 3119 C CB  . THR A 1 385 ? 35.673 -29.571 -18.375 1.00 27.94  ? 379 THR A CB  1 
ATOM 3120 O OG1 . THR A 1 385 ? 36.470 -28.384 -18.344 1.00 55.14  ? 379 THR A OG1 1 
ATOM 3121 C CG2 . THR A 1 385 ? 36.579 -30.778 -18.559 1.00 42.73  ? 379 THR A CG2 1 
ATOM 3122 N N   . LEU A 1 386 ? 33.612 -27.288 -19.751 1.00 40.51  ? 380 LEU A N   1 
ATOM 3123 C CA  . LEU A 1 386 ? 32.519 -26.337 -19.587 1.00 36.42  ? 380 LEU A CA  1 
ATOM 3124 C C   . LEU A 1 386 ? 31.279 -26.801 -20.340 1.00 46.74  ? 380 LEU A C   1 
ATOM 3125 O O   . LEU A 1 386 ? 30.175 -26.832 -19.783 1.00 49.93  ? 380 LEU A O   1 
ATOM 3126 C CB  . LEU A 1 386 ? 32.956 -24.952 -20.072 1.00 39.71  ? 380 LEU A CB  1 
ATOM 3127 C CG  . LEU A 1 386 ? 31.928 -23.819 -20.049 1.00 26.08  ? 380 LEU A CG  1 
ATOM 3128 C CD1 . LEU A 1 386 ? 31.474 -23.544 -18.629 1.00 27.76  ? 380 LEU A CD1 1 
ATOM 3129 C CD2 . LEU A 1 386 ? 32.490 -22.562 -20.692 1.00 27.17  ? 380 LEU A CD2 1 
ATOM 3130 N N   . ASN A 1 387 ? 31.445 -27.174 -21.609 1.00 59.70  ? 381 ASN A N   1 
ATOM 3131 C CA  . ASN A 1 387 ? 30.358 -27.648 -22.452 1.00 63.02  ? 381 ASN A CA  1 
ATOM 3132 C C   . ASN A 1 387 ? 30.162 -29.157 -22.360 1.00 68.38  ? 381 ASN A C   1 
ATOM 3133 O O   . ASN A 1 387 ? 29.517 -29.746 -23.236 1.00 68.25  ? 381 ASN A O   1 
ATOM 3134 C CB  . ASN A 1 387 ? 30.605 -27.239 -23.904 1.00 56.49  ? 381 ASN A CB  1 
ATOM 3135 C CG  . ASN A 1 387 ? 30.554 -25.741 -24.099 1.00 60.71  ? 381 ASN A CG  1 
ATOM 3136 O OD1 . ASN A 1 387 ? 29.956 -25.019 -23.300 1.00 61.59  ? 381 ASN A OD1 1 
ATOM 3137 N ND2 . ASN A 1 387 ? 31.191 -25.261 -25.160 1.00 77.30  ? 381 ASN A ND2 1 
ATOM 3138 N N   . ASP A 1 388 ? 30.711 -29.793 -21.331 1.00 73.31  ? 382 ASP A N   1 
ATOM 3139 C CA  . ASP A 1 388 ? 30.478 -31.212 -21.115 1.00 81.83  ? 382 ASP A CA  1 
ATOM 3140 C C   . ASP A 1 388 ? 29.025 -31.448 -20.720 1.00 86.48  ? 382 ASP A C   1 
ATOM 3141 O O   . ASP A 1 388 ? 28.411 -30.642 -20.014 1.00 72.52  ? 382 ASP A O   1 
ATOM 3142 C CB  . ASP A 1 388 ? 31.417 -31.743 -20.031 1.00 88.30  ? 382 ASP A CB  1 
ATOM 3143 C CG  . ASP A 1 388 ? 31.423 -33.254 -19.949 1.00 94.83  ? 382 ASP A CG  1 
ATOM 3144 O OD1 . ASP A 1 388 ? 30.922 -33.902 -20.891 1.00 71.60  ? 382 ASP A OD1 1 
ATOM 3145 O OD2 . ASP A 1 388 ? 31.929 -33.788 -18.938 1.00 116.66 ? 382 ASP A OD2 1 
ATOM 3146 N N   . GLU A 1 389 ? 28.469 -32.568 -21.192 1.00 90.98  ? 383 GLU A N   1 
ATOM 3147 C CA  . GLU A 1 389 ? 27.063 -32.854 -20.927 1.00 87.60  ? 383 GLU A CA  1 
ATOM 3148 C C   . GLU A 1 389 ? 26.826 -33.209 -19.465 1.00 75.83  ? 383 GLU A C   1 
ATOM 3149 O O   . GLU A 1 389 ? 25.713 -33.024 -18.960 1.00 73.57  ? 383 GLU A O   1 
ATOM 3150 C CB  . GLU A 1 389 ? 26.558 -33.981 -21.829 1.00 105.69 ? 383 GLU A CB  1 
ATOM 3151 C CG  . GLU A 1 389 ? 26.930 -35.398 -21.388 1.00 109.31 ? 383 GLU A CG  1 
ATOM 3152 C CD  . GLU A 1 389 ? 28.406 -35.708 -21.538 1.00 114.24 ? 383 GLU A CD  1 
ATOM 3153 O OE1 . GLU A 1 389 ? 28.974 -35.404 -22.605 1.00 121.65 ? 383 GLU A OE1 1 
ATOM 3154 O OE2 . GLU A 1 389 ? 28.996 -36.278 -20.597 1.00 89.87  ? 383 GLU A OE2 1 
ATOM 3155 N N   . LYS A 1 390 ? 27.845 -33.734 -18.779 1.00 78.11  ? 384 LYS A N   1 
ATOM 3156 C CA  . LYS A 1 390 ? 27.744 -33.911 -17.335 1.00 65.75  ? 384 LYS A CA  1 
ATOM 3157 C C   . LYS A 1 390 ? 27.493 -32.578 -16.652 1.00 71.77  ? 384 LYS A C   1 
ATOM 3158 O O   . LYS A 1 390 ? 26.775 -32.506 -15.649 1.00 67.12  ? 384 LYS A O   1 
ATOM 3159 C CB  . LYS A 1 390 ? 29.023 -34.541 -16.786 1.00 57.59  ? 384 LYS A CB  1 
ATOM 3160 C CG  . LYS A 1 390 ? 29.466 -35.802 -17.492 1.00 80.65  ? 384 LYS A CG  1 
ATOM 3161 C CD  . LYS A 1 390 ? 30.735 -36.360 -16.862 1.00 90.84  ? 384 LYS A CD  1 
ATOM 3162 C CE  . LYS A 1 390 ? 31.383 -37.418 -17.744 1.00 111.29 ? 384 LYS A CE  1 
ATOM 3163 N NZ  . LYS A 1 390 ? 32.696 -37.880 -17.206 1.00 92.65  ? 384 LYS A NZ  1 
ATOM 3164 N N   . HIS A 1 391 ? 28.080 -31.510 -17.186 1.00 68.67  ? 385 HIS A N   1 
ATOM 3165 C CA  . HIS A 1 391 ? 27.993 -30.181 -16.606 1.00 57.90  ? 385 HIS A CA  1 
ATOM 3166 C C   . HIS A 1 391 ? 26.956 -29.316 -17.308 1.00 55.44  ? 385 HIS A C   1 
ATOM 3167 O O   . HIS A 1 391 ? 27.085 -28.089 -17.332 1.00 52.31  ? 385 HIS A O   1 
ATOM 3168 C CB  . HIS A 1 391 ? 29.368 -29.519 -16.642 1.00 54.52  ? 385 HIS A CB  1 
ATOM 3169 C CG  . HIS A 1 391 ? 30.403 -30.261 -15.863 1.00 59.24  ? 385 HIS A CG  1 
ATOM 3170 N ND1 . HIS A 1 391 ? 30.233 -30.597 -14.534 1.00 80.44  ? 385 HIS A ND1 1 
ATOM 3171 C CD2 . HIS A 1 391 ? 31.615 -30.746 -16.218 1.00 60.41  ? 385 HIS A CD2 1 
ATOM 3172 C CE1 . HIS A 1 391 ? 31.295 -31.254 -14.110 1.00 86.00  ? 385 HIS A CE1 1 
ATOM 3173 N NE2 . HIS A 1 391 ? 32.152 -31.356 -15.112 1.00 86.05  ? 385 HIS A NE2 1 
ATOM 3174 N N   . LYS A 1 392 ? 25.931 -29.939 -17.895 1.00 51.09  ? 386 LYS A N   1 
ATOM 3175 C CA  . LYS A 1 392 ? 24.864 -29.178 -18.536 1.00 43.75  ? 386 LYS A CA  1 
ATOM 3176 C C   . LYS A 1 392 ? 23.967 -28.511 -17.501 1.00 46.31  ? 386 LYS A C   1 
ATOM 3177 O O   . LYS A 1 392 ? 23.480 -27.395 -17.718 1.00 35.03  ? 386 LYS A O   1 
ATOM 3178 C CB  . LYS A 1 392 ? 24.050 -30.092 -19.453 1.00 45.95  ? 386 LYS A CB  1 
ATOM 3179 C CG  . LYS A 1 392 ? 22.875 -29.407 -20.123 1.00 64.91  ? 386 LYS A CG  1 
ATOM 3180 C CD  . LYS A 1 392 ? 22.231 -30.311 -21.158 1.00 81.97  ? 386 LYS A CD  1 
ATOM 3181 C CE  . LYS A 1 392 ? 21.044 -29.634 -21.829 1.00 68.69  ? 386 LYS A CE  1 
ATOM 3182 N NZ  . LYS A 1 392 ? 20.405 -30.512 -22.854 1.00 75.45  ? 386 LYS A NZ  1 
ATOM 3183 N N   . GLY A 1 393 ? 23.748 -29.173 -16.362 1.00 59.51  ? 387 GLY A N   1 
ATOM 3184 C CA  . GLY A 1 393 ? 22.928 -28.572 -15.320 1.00 45.36  ? 387 GLY A CA  1 
ATOM 3185 C C   . GLY A 1 393 ? 23.554 -27.318 -14.739 1.00 45.17  ? 387 GLY A C   1 
ATOM 3186 O O   . GLY A 1 393 ? 22.865 -26.329 -14.470 1.00 48.56  ? 387 GLY A O   1 
ATOM 3187 N N   . ILE A 1 394 ? 24.873 -27.338 -14.547 1.00 44.26  ? 388 ILE A N   1 
ATOM 3188 C CA  . ILE A 1 394 ? 25.577 -26.154 -14.060 1.00 39.69  ? 388 ILE A CA  1 
ATOM 3189 C C   . ILE A 1 394 ? 25.473 -25.018 -15.071 1.00 40.51  ? 388 ILE A C   1 
ATOM 3190 O O   . ILE A 1 394 ? 25.257 -23.855 -14.709 1.00 36.97  ? 388 ILE A O   1 
ATOM 3191 C CB  . ILE A 1 394 ? 27.046 -26.495 -13.756 1.00 37.74  ? 388 ILE A CB  1 
ATOM 3192 C CG1 . ILE A 1 394 ? 27.122 -27.648 -12.766 1.00 47.39  ? 388 ILE A CG1 1 
ATOM 3193 C CG2 . ILE A 1 394 ? 27.765 -25.284 -13.184 1.00 47.41  ? 388 ILE A CG2 1 
ATOM 3194 C CD1 . ILE A 1 394 ? 28.525 -28.138 -12.507 1.00 64.65  ? 388 ILE A CD1 1 
ATOM 3195 N N   . LEU A 1 395 ? 25.633 -25.338 -16.358 1.00 35.61  ? 389 LEU A N   1 
ATOM 3196 C CA  . LEU A 1 395 ? 25.482 -24.330 -17.403 1.00 30.85  ? 389 LEU A CA  1 
ATOM 3197 C C   . LEU A 1 395 ? 24.095 -23.705 -17.365 1.00 38.07  ? 389 LEU A C   1 
ATOM 3198 O O   . LEU A 1 395 ? 23.950 -22.479 -17.370 1.00 57.72  ? 389 LEU A O   1 
ATOM 3199 C CB  . LEU A 1 395 ? 25.746 -24.944 -18.781 1.00 42.59  ? 389 LEU A CB  1 
ATOM 3200 C CG  . LEU A 1 395 ? 27.190 -25.220 -19.199 1.00 48.09  ? 389 LEU A CG  1 
ATOM 3201 C CD1 . LEU A 1 395 ? 27.222 -25.944 -20.534 1.00 50.89  ? 389 LEU A CD1 1 
ATOM 3202 C CD2 . LEU A 1 395 ? 27.970 -23.921 -19.282 1.00 37.94  ? 389 LEU A CD2 1 
ATOM 3203 N N   . ASP A 1 396 ? 23.060 -24.544 -17.320 1.00 35.37  ? 390 ASP A N   1 
ATOM 3204 C CA  . ASP A 1 396 ? 21.692 -24.042 -17.341 1.00 35.96  ? 390 ASP A CA  1 
ATOM 3205 C C   . ASP A 1 396 ? 21.350 -23.285 -16.067 1.00 39.67  ? 390 ASP A C   1 
ATOM 3206 O O   . ASP A 1 396 ? 20.474 -22.414 -16.083 1.00 40.80  ? 390 ASP A O   1 
ATOM 3207 C CB  . ASP A 1 396 ? 20.729 -25.204 -17.545 1.00 40.19  ? 390 ASP A CB  1 
ATOM 3208 C CG  . ASP A 1 396 ? 20.855 -25.816 -18.914 1.00 65.99  ? 390 ASP A CG  1 
ATOM 3209 O OD1 . ASP A 1 396 ? 21.538 -25.211 -19.765 1.00 81.52  ? 390 ASP A OD1 1 
ATOM 3210 O OD2 . ASP A 1 396 ? 20.292 -26.906 -19.135 1.00 84.02  ? 390 ASP A OD2 1 
ATOM 3211 N N   . ALA A 1 397 ? 22.016 -23.610 -14.958 1.00 33.60  ? 391 ALA A N   1 
ATOM 3212 C CA  . ALA A 1 397 ? 21.810 -22.866 -13.724 1.00 34.65  ? 391 ALA A CA  1 
ATOM 3213 C C   . ALA A 1 397 ? 22.529 -21.523 -13.737 1.00 39.34  ? 391 ALA A C   1 
ATOM 3214 O O   . ALA A 1 397 ? 22.018 -20.552 -13.168 1.00 41.46  ? 391 ALA A O   1 
ATOM 3215 C CB  . ALA A 1 397 ? 22.268 -23.701 -12.529 1.00 60.02  ? 391 ALA A CB  1 
ATOM 3216 N N   . LEU A 1 398 ? 23.706 -21.447 -14.363 1.00 34.38  ? 392 LEU A N   1 
ATOM 3217 C CA  . LEU A 1 398 ? 24.368 -20.162 -14.546 1.00 38.23  ? 392 LEU A CA  1 
ATOM 3218 C C   . LEU A 1 398 ? 23.770 -19.369 -15.698 1.00 38.69  ? 392 LEU A C   1 
ATOM 3219 O O   . LEU A 1 398 ? 24.000 -18.159 -15.786 1.00 34.90  ? 392 LEU A O   1 
ATOM 3220 C CB  . LEU A 1 398 ? 25.871 -20.357 -14.745 1.00 31.28  ? 392 LEU A CB  1 
ATOM 3221 C CG  . LEU A 1 398 ? 26.573 -20.865 -13.484 1.00 25.87  ? 392 LEU A CG  1 
ATOM 3222 C CD1 . LEU A 1 398 ? 27.991 -21.308 -13.782 1.00 28.24  ? 392 LEU A CD1 1 
ATOM 3223 C CD2 . LEU A 1 398 ? 26.554 -19.791 -12.402 1.00 26.08  ? 392 LEU A CD2 1 
ATOM 3224 N N   . GLN A 1 399 ? 23.023 -20.025 -16.582 1.00 39.96  ? 393 GLN A N   1 
ATOM 3225 C CA  . GLN A 1 399 ? 22.032 -19.348 -17.396 1.00 41.09  ? 393 GLN A CA  1 
ATOM 3226 C C   . GLN A 1 399 ? 20.786 -19.132 -16.536 1.00 49.00  ? 393 GLN A C   1 
ATOM 3227 O O   . GLN A 1 399 ? 20.710 -19.587 -15.392 1.00 58.28  ? 393 GLN A O   1 
ATOM 3228 C CB  . GLN A 1 399 ? 21.730 -20.161 -18.656 1.00 37.96  ? 393 GLN A CB  1 
ATOM 3229 C CG  . GLN A 1 399 ? 22.886 -20.219 -19.659 1.00 38.37  ? 393 GLN A CG  1 
ATOM 3230 C CD  . GLN A 1 399 ? 22.621 -21.154 -20.827 1.00 41.60  ? 393 GLN A CD  1 
ATOM 3231 O OE1 . GLN A 1 399 ? 21.981 -20.774 -21.808 1.00 49.16  ? 393 GLN A OE1 1 
ATOM 3232 N NE2 . GLN A 1 399 ? 23.128 -22.375 -20.733 1.00 40.19  ? 393 GLN A NE2 1 
ATOM 3233 N N   . GLY A 1 400 ? 19.793 -18.430 -17.067 1.00 48.89  ? 394 GLY A N   1 
ATOM 3234 C CA  . GLY A 1 400 ? 18.606 -18.188 -16.270 1.00 39.79  ? 394 GLY A CA  1 
ATOM 3235 C C   . GLY A 1 400 ? 17.478 -19.169 -16.520 1.00 40.06  ? 394 GLY A C   1 
ATOM 3236 O O   . GLY A 1 400 ? 16.315 -18.764 -16.592 1.00 49.29  ? 394 GLY A O   1 
ATOM 3237 N N   . ILE A 1 401 ? 17.790 -20.460 -16.637 1.00 34.77  ? 395 ILE A N   1 
ATOM 3238 C CA  . ILE A 1 401 ? 16.824 -21.407 -17.187 1.00 33.84  ? 395 ILE A CA  1 
ATOM 3239 C C   . ILE A 1 401 ? 16.747 -22.717 -16.409 1.00 34.31  ? 395 ILE A C   1 
ATOM 3240 O O   . ILE A 1 401 ? 16.163 -23.693 -16.895 1.00 36.70  ? 395 ILE A O   1 
ATOM 3241 C CB  . ILE A 1 401 ? 17.146 -21.689 -18.668 1.00 33.01  ? 395 ILE A CB  1 
ATOM 3242 C CG1 . ILE A 1 401 ? 18.583 -22.196 -18.815 1.00 33.55  ? 395 ILE A CG1 1 
ATOM 3243 C CG2 . ILE A 1 401 ? 16.913 -20.450 -19.528 1.00 22.60  ? 395 ILE A CG2 1 
ATOM 3244 C CD1 . ILE A 1 401 ? 18.945 -22.618 -20.223 1.00 30.37  ? 395 ILE A CD1 1 
ATOM 3245 N N   . ALA A 1 402 ? 17.308 -22.763 -15.202 1.00 43.73  ? 396 ALA A N   1 
ATOM 3246 C CA  . ALA A 1 402 ? 17.315 -24.010 -14.446 1.00 46.03  ? 396 ALA A CA  1 
ATOM 3247 C C   . ALA A 1 402 ? 17.469 -23.727 -12.957 1.00 62.57  ? 396 ALA A C   1 
ATOM 3248 O O   . ALA A 1 402 ? 17.621 -22.580 -12.528 1.00 71.10  ? 396 ALA A O   1 
ATOM 3249 C CB  . ALA A 1 402 ? 18.426 -24.945 -14.930 1.00 50.97  ? 396 ALA A CB  1 
ATOM 3250 N N   . ASP A 1 403 ? 17.421 -24.797 -12.170 1.00 63.72  ? 397 ASP A N   1 
ATOM 3251 C CA  . ASP A 1 403 ? 17.639 -24.758 -10.734 1.00 59.93  ? 397 ASP A CA  1 
ATOM 3252 C C   . ASP A 1 403 ? 19.094 -25.101 -10.436 1.00 65.71  ? 397 ASP A C   1 
ATOM 3253 O O   . ASP A 1 403 ? 19.714 -25.908 -11.134 1.00 80.46  ? 397 ASP A O   1 
ATOM 3254 C CB  . ASP A 1 403 ? 16.701 -25.738 -10.022 1.00 85.32  ? 397 ASP A CB  1 
ATOM 3255 C CG  . ASP A 1 403 ? 16.878 -25.733 -8.516  1.00 112.27 ? 397 ASP A CG  1 
ATOM 3256 O OD1 . ASP A 1 403 ? 17.296 -24.691 -7.965  1.00 114.96 ? 397 ASP A OD1 1 
ATOM 3257 O OD2 . ASP A 1 403 ? 16.596 -26.773 -7.882  1.00 113.24 ? 397 ASP A OD2 1 
ATOM 3258 N N   . GLY A 1 404 ? 19.639 -24.469 -9.400  1.00 60.00  ? 398 GLY A N   1 
ATOM 3259 C CA  . GLY A 1 404 ? 21.037 -24.642 -9.056  1.00 60.73  ? 398 GLY A CA  1 
ATOM 3260 C C   . GLY A 1 404 ? 21.348 -25.918 -8.299  1.00 74.50  ? 398 GLY A C   1 
ATOM 3261 O O   . GLY A 1 404 ? 20.870 -26.118 -7.179  1.00 51.81  ? 398 GLY A O   1 
ATOM 3262 N N   . ARG A 1 405 ? 22.151 -26.788 -8.909  1.00 85.02  ? 399 ARG A N   1 
ATOM 3263 C CA  . ARG A 1 405 ? 22.641 -28.001 -8.265  1.00 68.18  ? 399 ARG A CA  1 
ATOM 3264 C C   . ARG A 1 405 ? 24.059 -28.260 -8.746  1.00 68.10  ? 399 ARG A C   1 
ATOM 3265 O O   . ARG A 1 405 ? 24.292 -28.422 -9.948  1.00 67.95  ? 399 ARG A O   1 
ATOM 3266 C CB  . ARG A 1 405 ? 21.749 -29.203 -8.573  1.00 85.86  ? 399 ARG A CB  1 
ATOM 3267 C CG  . ARG A 1 405 ? 22.130 -30.443 -7.784  1.00 79.13  ? 399 ARG A CG  1 
ATOM 3268 C CD  . ARG A 1 405 ? 22.069 -30.161 -6.299  1.00 78.06  ? 399 ARG A CD  1 
ATOM 3269 N NE  . ARG A 1 405 ? 22.367 -31.342 -5.498  1.00 121.26 ? 399 ARG A NE  1 
ATOM 3270 C CZ  . ARG A 1 405 ? 22.550 -31.320 -4.184  1.00 125.78 ? 399 ARG A CZ  1 
ATOM 3271 N NH1 . ARG A 1 405 ? 22.493 -30.188 -3.497  1.00 131.06 ? 399 ARG A NH1 1 
ATOM 3272 N NH2 . ARG A 1 405 ? 22.790 -32.461 -3.541  1.00 122.86 ? 399 ARG A NH2 1 
ATOM 3273 N N   . ASP A 1 406 ? 24.997 -28.309 -7.802  1.00 60.43  ? 400 ASP A N   1 
ATOM 3274 C CA  . ASP A 1 406 ? 26.416 -28.416 -8.099  1.00 55.99  ? 400 ASP A CA  1 
ATOM 3275 C C   . ASP A 1 406 ? 27.101 -29.591 -7.423  1.00 65.42  ? 400 ASP A C   1 
ATOM 3276 O O   . ASP A 1 406 ? 28.152 -30.031 -7.901  1.00 60.29  ? 400 ASP A O   1 
ATOM 3277 C CB  . ASP A 1 406 ? 27.133 -27.123 -7.677  1.00 67.73  ? 400 ASP A CB  1 
ATOM 3278 C CG  . ASP A 1 406 ? 28.577 -27.076 -8.124  1.00 67.62  ? 400 ASP A CG  1 
ATOM 3279 O OD1 . ASP A 1 406 ? 28.890 -27.618 -9.205  1.00 64.65  ? 400 ASP A OD1 1 
ATOM 3280 O OD2 . ASP A 1 406 ? 29.399 -26.501 -7.380  1.00 47.50  ? 400 ASP A OD2 1 
ATOM 3281 N N   . GLN A 1 407 ? 26.534 -30.116 -6.341  1.00 76.67  ? 401 GLN A N   1 
ATOM 3282 C CA  . GLN A 1 407 ? 27.238 -31.053 -5.480  1.00 62.72  ? 401 GLN A CA  1 
ATOM 3283 C C   . GLN A 1 407 ? 27.363 -32.446 -6.083  1.00 52.19  ? 401 GLN A C   1 
ATOM 3284 O O   . GLN A 1 407 ? 28.187 -33.238 -5.612  1.00 69.75  ? 401 GLN A O   1 
ATOM 3285 C CB  . GLN A 1 407 ? 26.520 -31.123 -4.133  1.00 78.84  ? 401 GLN A CB  1 
ATOM 3286 C CG  . GLN A 1 407 ? 26.601 -29.830 -3.330  1.00 62.44  ? 401 GLN A CG  1 
ATOM 3287 C CD  . GLN A 1 407 ? 25.863 -29.926 -2.013  1.00 100.60 ? 401 GLN A CD  1 
ATOM 3288 O OE1 . GLN A 1 407 ? 25.397 -30.999 -1.633  1.00 127.32 ? 401 GLN A OE1 1 
ATOM 3289 N NE2 . GLN A 1 407 ? 25.747 -28.804 -1.311  1.00 77.88  ? 401 GLN A NE2 1 
ATOM 3290 N N   . LEU A 1 408 ? 26.578 -32.765 -7.108  1.00 54.76  ? 402 LEU A N   1 
ATOM 3291 C CA  . LEU A 1 408 ? 26.575 -34.101 -7.688  1.00 74.01  ? 402 LEU A CA  1 
ATOM 3292 C C   . LEU A 1 408 ? 27.567 -34.259 -8.837  1.00 74.46  ? 402 LEU A C   1 
ATOM 3293 O O   . LEU A 1 408 ? 27.547 -35.291 -9.517  1.00 73.83  ? 402 LEU A O   1 
ATOM 3294 C CB  . LEU A 1 408 ? 25.164 -34.461 -8.163  1.00 83.76  ? 402 LEU A CB  1 
ATOM 3295 C CG  . LEU A 1 408 ? 24.050 -34.346 -7.119  1.00 90.75  ? 402 LEU A CG  1 
ATOM 3296 C CD1 . LEU A 1 408 ? 22.690 -34.623 -7.746  1.00 94.74  ? 402 LEU A CD1 1 
ATOM 3297 C CD2 . LEU A 1 408 ? 24.308 -35.290 -5.953  1.00 89.04  ? 402 LEU A CD2 1 
ATOM 3298 N N   . LEU A 1 409 ? 28.440 -33.274 -9.062  1.00 76.86  ? 403 LEU A N   1 
ATOM 3299 C CA  . LEU A 1 409 ? 29.337 -33.296 -10.209 1.00 83.52  ? 403 LEU A CA  1 
ATOM 3300 C C   . LEU A 1 409 ? 30.800 -33.053 -9.863  1.00 84.74  ? 403 LEU A C   1 
ATOM 3301 O O   . LEU A 1 409 ? 31.662 -33.310 -10.710 1.00 89.32  ? 403 LEU A O   1 
ATOM 3302 C CB  . LEU A 1 409 ? 28.885 -32.261 -11.250 1.00 67.61  ? 403 LEU A CB  1 
ATOM 3303 C CG  . LEU A 1 409 ? 27.515 -32.574 -11.862 1.00 84.77  ? 403 LEU A CG  1 
ATOM 3304 C CD1 . LEU A 1 409 ? 26.958 -31.394 -12.640 1.00 89.47  ? 403 LEU A CD1 1 
ATOM 3305 C CD2 . LEU A 1 409 ? 27.596 -33.809 -12.749 1.00 92.19  ? 403 LEU A CD2 1 
ATOM 3306 N N   . LYS A 1 410 ? 31.107 -32.562 -8.661  1.00 94.21  ? 404 LYS A N   1 
ATOM 3307 C CA  . LYS A 1 410 ? 32.475 -32.447 -8.181  1.00 80.48  ? 404 LYS A CA  1 
ATOM 3308 C C   . LYS A 1 410 ? 32.764 -33.338 -6.982  1.00 94.95  ? 404 LYS A C   1 
ATOM 3309 O O   . LYS A 1 410 ? 33.942 -33.568 -6.675  1.00 98.35  ? 404 LYS A O   1 
ATOM 3310 C CB  . LYS A 1 410 ? 32.797 -30.991 -7.808  1.00 82.96  ? 404 LYS A CB  1 
ATOM 3311 C CG  . LYS A 1 410 ? 33.094 -30.088 -8.993  1.00 91.38  ? 404 LYS A CG  1 
ATOM 3312 C CD  . LYS A 1 410 ? 33.341 -28.659 -8.546  1.00 59.52  ? 404 LYS A CD  1 
ATOM 3313 C CE  . LYS A 1 410 ? 32.030 -27.997 -8.162  1.00 74.57  ? 404 LYS A CE  1 
ATOM 3314 N NZ  . LYS A 1 410 ? 32.231 -26.650 -7.567  1.00 85.05  ? 404 LYS A NZ  1 
ATOM 3315 N N   . THR A 1 411 ? 31.734 -33.823 -6.287  1.00 112.13 ? 405 THR A N   1 
ATOM 3316 C CA  . THR A 1 411 ? 31.875 -34.797 -5.211  1.00 116.73 ? 405 THR A CA  1 
ATOM 3317 C C   . THR A 1 411 ? 31.366 -36.174 -5.599  1.00 115.39 ? 405 THR A C   1 
ATOM 3318 O O   . THR A 1 411 ? 31.988 -37.180 -5.242  1.00 112.49 ? 405 THR A O   1 
ATOM 3319 C CB  . THR A 1 411 ? 31.132 -34.320 -3.955  1.00 104.55 ? 405 THR A CB  1 
ATOM 3320 O OG1 . THR A 1 411 ? 31.636 -33.040 -3.553  1.00 82.93  ? 405 THR A OG1 1 
ATOM 3321 C CG2 . THR A 1 411 ? 31.311 -35.316 -2.814  1.00 114.05 ? 405 THR A CG2 1 
ATOM 3322 N N   . GLN A 1 412 ? 30.250 -36.236 -6.325  1.00 100.49 ? 406 GLN A N   1 
ATOM 3323 C CA  . GLN A 1 412 ? 29.723 -37.481 -6.879  1.00 97.01  ? 406 GLN A CA  1 
ATOM 3324 C C   . GLN A 1 412 ? 29.539 -38.567 -5.820  1.00 93.06  ? 406 GLN A C   1 
ATOM 3325 O O   . GLN A 1 412 ? 29.777 -39.747 -6.081  1.00 88.90  ? 406 GLN A O   1 
ATOM 3326 C CB  . GLN A 1 412 ? 30.642 -37.986 -7.992  1.00 104.60 ? 406 GLN A CB  1 
ATOM 3327 C CG  . GLN A 1 412 ? 30.908 -36.963 -9.087  1.00 85.96  ? 406 GLN A CG  1 
ATOM 3328 C CD  . GLN A 1 412 ? 31.790 -37.513 -10.191 1.00 97.07  ? 406 GLN A CD  1 
ATOM 3329 O OE1 . GLN A 1 412 ? 32.129 -38.697 -10.199 1.00 111.08 ? 406 GLN A OE1 1 
ATOM 3330 N NE2 . GLN A 1 412 ? 32.177 -36.650 -11.125 1.00 83.94  ? 406 GLN A NE2 1 
# 
