data_8ZVT
# 
_entry.id   8ZVT 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZVT         pdb_00008zvt 10.2210/pdb8zvt/pdb 
WWPDB D_1300048625 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZVT 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-12 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yl521gl@ustc.edu.cn 
_pdbx_contact_author.name_first         Lin 
_pdbx_contact_author.name_last          Yang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1550-6947 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Yang, L.Y.' 1 0000-0003-1550-6947 
'Fang, Y.J.' 2 0009-0009-0272-0830 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Human citrate synthase intermediate 3' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yang, L.Y.' 1 0000-0003-1550-6947 
primary 'Fang, Y.J.' 2 0009-0009-0272-0830 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Citrate synthase, mitochondrial' 48790.703 1   2.3.3.1 ? ? ? 
2 non-polymer syn 'OXALOACETATE ION'                131.064   1   ?       ? ? ? 
3 non-polymer syn 'ACETIC ACID'                     60.052    1   ?       ? ? ? 
4 non-polymer syn 'COENZYME A'                      767.534   1   ?       ? ? ? 
5 water       nat water                             18.015    152 ?       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Citrate (Si)-synthase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;ASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPK
AKGGEEPLPEGLFWLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFARAYAQ
GISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTRLYLTIHSDHEG
GNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGH
AVLRKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVS
RALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;ASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPK
AKGGEEPLPEGLFWLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFARAYAQ
GISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTRLYLTIHSDHEG
GNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGH
AVLRKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVS
RALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDS
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'OXALOACETATE ION' OAA 
3 'ACETIC ACID'      ACY 
4 'COENZYME A'       COA 
5 water              HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   SER n 
1 3   SER n 
1 4   THR n 
1 5   ASN n 
1 6   LEU n 
1 7   LYS n 
1 8   ASP n 
1 9   ILE n 
1 10  LEU n 
1 11  ALA n 
1 12  ASP n 
1 13  LEU n 
1 14  ILE n 
1 15  PRO n 
1 16  LYS n 
1 17  GLU n 
1 18  GLN n 
1 19  ALA n 
1 20  ARG n 
1 21  ILE n 
1 22  LYS n 
1 23  THR n 
1 24  PHE n 
1 25  ARG n 
1 26  GLN n 
1 27  GLN n 
1 28  HIS n 
1 29  GLY n 
1 30  LYS n 
1 31  THR n 
1 32  VAL n 
1 33  VAL n 
1 34  GLY n 
1 35  GLN n 
1 36  ILE n 
1 37  THR n 
1 38  VAL n 
1 39  ASP n 
1 40  MET n 
1 41  MET n 
1 42  TYR n 
1 43  GLY n 
1 44  GLY n 
1 45  MET n 
1 46  ARG n 
1 47  GLY n 
1 48  MET n 
1 49  LYS n 
1 50  GLY n 
1 51  LEU n 
1 52  VAL n 
1 53  TYR n 
1 54  GLU n 
1 55  THR n 
1 56  SER n 
1 57  VAL n 
1 58  LEU n 
1 59  ASP n 
1 60  PRO n 
1 61  ASP n 
1 62  GLU n 
1 63  GLY n 
1 64  ILE n 
1 65  ARG n 
1 66  PHE n 
1 67  ARG n 
1 68  GLY n 
1 69  PHE n 
1 70  SER n 
1 71  ILE n 
1 72  PRO n 
1 73  GLU n 
1 74  CYS n 
1 75  GLN n 
1 76  LYS n 
1 77  LEU n 
1 78  LEU n 
1 79  PRO n 
1 80  LYS n 
1 81  ALA n 
1 82  LYS n 
1 83  GLY n 
1 84  GLY n 
1 85  GLU n 
1 86  GLU n 
1 87  PRO n 
1 88  LEU n 
1 89  PRO n 
1 90  GLU n 
1 91  GLY n 
1 92  LEU n 
1 93  PHE n 
1 94  TRP n 
1 95  LEU n 
1 96  LEU n 
1 97  VAL n 
1 98  THR n 
1 99  GLY n 
1 100 HIS n 
1 101 ILE n 
1 102 PRO n 
1 103 THR n 
1 104 GLU n 
1 105 GLU n 
1 106 GLN n 
1 107 VAL n 
1 108 SER n 
1 109 TRP n 
1 110 LEU n 
1 111 SER n 
1 112 LYS n 
1 113 GLU n 
1 114 TRP n 
1 115 ALA n 
1 116 LYS n 
1 117 ARG n 
1 118 ALA n 
1 119 ALA n 
1 120 LEU n 
1 121 PRO n 
1 122 SER n 
1 123 HIS n 
1 124 VAL n 
1 125 VAL n 
1 126 THR n 
1 127 MET n 
1 128 LEU n 
1 129 ASP n 
1 130 ASN n 
1 131 PHE n 
1 132 PRO n 
1 133 THR n 
1 134 ASN n 
1 135 LEU n 
1 136 HIS n 
1 137 PRO n 
1 138 MET n 
1 139 SER n 
1 140 GLN n 
1 141 LEU n 
1 142 SER n 
1 143 ALA n 
1 144 ALA n 
1 145 VAL n 
1 146 THR n 
1 147 ALA n 
1 148 LEU n 
1 149 ASN n 
1 150 SER n 
1 151 GLU n 
1 152 SER n 
1 153 ASN n 
1 154 PHE n 
1 155 ALA n 
1 156 ARG n 
1 157 ALA n 
1 158 TYR n 
1 159 ALA n 
1 160 GLN n 
1 161 GLY n 
1 162 ILE n 
1 163 SER n 
1 164 ARG n 
1 165 THR n 
1 166 LYS n 
1 167 TYR n 
1 168 TRP n 
1 169 GLU n 
1 170 LEU n 
1 171 ILE n 
1 172 TYR n 
1 173 GLU n 
1 174 ASP n 
1 175 SER n 
1 176 MET n 
1 177 ASP n 
1 178 LEU n 
1 179 ILE n 
1 180 ALA n 
1 181 LYS n 
1 182 LEU n 
1 183 PRO n 
1 184 CYS n 
1 185 VAL n 
1 186 ALA n 
1 187 ALA n 
1 188 LYS n 
1 189 ILE n 
1 190 TYR n 
1 191 ARG n 
1 192 ASN n 
1 193 LEU n 
1 194 TYR n 
1 195 ARG n 
1 196 GLU n 
1 197 GLY n 
1 198 SER n 
1 199 GLY n 
1 200 ILE n 
1 201 GLY n 
1 202 ALA n 
1 203 ILE n 
1 204 ASP n 
1 205 SER n 
1 206 ASN n 
1 207 LEU n 
1 208 ASP n 
1 209 TRP n 
1 210 SER n 
1 211 HIS n 
1 212 ASN n 
1 213 PHE n 
1 214 THR n 
1 215 ASN n 
1 216 MET n 
1 217 LEU n 
1 218 GLY n 
1 219 TYR n 
1 220 THR n 
1 221 ASP n 
1 222 HIS n 
1 223 GLN n 
1 224 PHE n 
1 225 THR n 
1 226 GLU n 
1 227 LEU n 
1 228 THR n 
1 229 ARG n 
1 230 LEU n 
1 231 TYR n 
1 232 LEU n 
1 233 THR n 
1 234 ILE n 
1 235 HIS n 
1 236 SER n 
1 237 ASP n 
1 238 HIS n 
1 239 GLU n 
1 240 GLY n 
1 241 GLY n 
1 242 ASN n 
1 243 VAL n 
1 244 SER n 
1 245 ALA n 
1 246 HIS n 
1 247 THR n 
1 248 SER n 
1 249 HIS n 
1 250 LEU n 
1 251 VAL n 
1 252 GLY n 
1 253 SER n 
1 254 ALA n 
1 255 LEU n 
1 256 SER n 
1 257 ASP n 
1 258 PRO n 
1 259 TYR n 
1 260 LEU n 
1 261 SER n 
1 262 PHE n 
1 263 ALA n 
1 264 ALA n 
1 265 ALA n 
1 266 MET n 
1 267 ASN n 
1 268 GLY n 
1 269 LEU n 
1 270 ALA n 
1 271 GLY n 
1 272 PRO n 
1 273 LEU n 
1 274 HIS n 
1 275 GLY n 
1 276 LEU n 
1 277 ALA n 
1 278 ASN n 
1 279 GLN n 
1 280 GLU n 
1 281 VAL n 
1 282 LEU n 
1 283 VAL n 
1 284 TRP n 
1 285 LEU n 
1 286 THR n 
1 287 GLN n 
1 288 LEU n 
1 289 GLN n 
1 290 LYS n 
1 291 GLU n 
1 292 VAL n 
1 293 GLY n 
1 294 LYS n 
1 295 ASP n 
1 296 VAL n 
1 297 SER n 
1 298 ASP n 
1 299 GLU n 
1 300 LYS n 
1 301 LEU n 
1 302 ARG n 
1 303 ASP n 
1 304 TYR n 
1 305 ILE n 
1 306 TRP n 
1 307 ASN n 
1 308 THR n 
1 309 LEU n 
1 310 ASN n 
1 311 SER n 
1 312 GLY n 
1 313 ARG n 
1 314 VAL n 
1 315 VAL n 
1 316 PRO n 
1 317 GLY n 
1 318 TYR n 
1 319 GLY n 
1 320 HIS n 
1 321 ALA n 
1 322 VAL n 
1 323 LEU n 
1 324 ARG n 
1 325 LYS n 
1 326 THR n 
1 327 ASP n 
1 328 PRO n 
1 329 ARG n 
1 330 TYR n 
1 331 THR n 
1 332 CYS n 
1 333 GLN n 
1 334 ARG n 
1 335 GLU n 
1 336 PHE n 
1 337 ALA n 
1 338 LEU n 
1 339 LYS n 
1 340 HIS n 
1 341 LEU n 
1 342 PRO n 
1 343 ASN n 
1 344 ASP n 
1 345 PRO n 
1 346 MET n 
1 347 PHE n 
1 348 LYS n 
1 349 LEU n 
1 350 VAL n 
1 351 ALA n 
1 352 GLN n 
1 353 LEU n 
1 354 TYR n 
1 355 LYS n 
1 356 ILE n 
1 357 VAL n 
1 358 PRO n 
1 359 ASN n 
1 360 VAL n 
1 361 LEU n 
1 362 LEU n 
1 363 GLU n 
1 364 GLN n 
1 365 GLY n 
1 366 LYS n 
1 367 ALA n 
1 368 LYS n 
1 369 ASN n 
1 370 PRO n 
1 371 TRP n 
1 372 PRO n 
1 373 ASN n 
1 374 VAL n 
1 375 ASP n 
1 376 ALA n 
1 377 HIS n 
1 378 SER n 
1 379 GLY n 
1 380 VAL n 
1 381 LEU n 
1 382 LEU n 
1 383 GLN n 
1 384 TYR n 
1 385 TYR n 
1 386 GLY n 
1 387 MET n 
1 388 THR n 
1 389 GLU n 
1 390 MET n 
1 391 ASN n 
1 392 TYR n 
1 393 TYR n 
1 394 THR n 
1 395 VAL n 
1 396 LEU n 
1 397 PHE n 
1 398 GLY n 
1 399 VAL n 
1 400 SER n 
1 401 ARG n 
1 402 ALA n 
1 403 LEU n 
1 404 GLY n 
1 405 VAL n 
1 406 LEU n 
1 407 ALA n 
1 408 GLN n 
1 409 LEU n 
1 410 ILE n 
1 411 TRP n 
1 412 SER n 
1 413 ARG n 
1 414 ALA n 
1 415 LEU n 
1 416 GLY n 
1 417 PHE n 
1 418 PRO n 
1 419 LEU n 
1 420 GLU n 
1 421 ARG n 
1 422 PRO n 
1 423 LYS n 
1 424 SER n 
1 425 MET n 
1 426 SER n 
1 427 THR n 
1 428 GLU n 
1 429 GLY n 
1 430 LEU n 
1 431 MET n 
1 432 LYS n 
1 433 PHE n 
1 434 VAL n 
1 435 ASP n 
1 436 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   436 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 CS 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACY non-polymer         . 'ACETIC ACID'      ? 'C2 H4 O2'            60.052  
ALA 'L-peptide linking' y ALANINE            ? 'C3 H7 N O2'          89.093  
ARG 'L-peptide linking' y ARGININE           ? 'C6 H15 N4 O2 1'      175.209 
ASN 'L-peptide linking' y ASPARAGINE         ? 'C4 H8 N2 O3'         132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'    ? 'C4 H7 N O4'          133.103 
COA non-polymer         . 'COENZYME A'       ? 'C21 H36 N7 O16 P3 S' 767.534 
CYS 'L-peptide linking' y CYSTEINE           ? 'C3 H7 N O2 S'        121.158 
GLN 'L-peptide linking' y GLUTAMINE          ? 'C5 H10 N2 O3'        146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'    ? 'C5 H9 N O4'          147.129 
GLY 'peptide linking'   y GLYCINE            ? 'C2 H5 N O2'          75.067  
HIS 'L-peptide linking' y HISTIDINE          ? 'C6 H10 N3 O2 1'      156.162 
HOH non-polymer         . WATER              ? 'H2 O'                18.015  
ILE 'L-peptide linking' y ISOLEUCINE         ? 'C6 H13 N O2'         131.173 
LEU 'L-peptide linking' y LEUCINE            ? 'C6 H13 N O2'         131.173 
LYS 'L-peptide linking' y LYSINE             ? 'C6 H15 N2 O2 1'      147.195 
MET 'L-peptide linking' y METHIONINE         ? 'C5 H11 N O2 S'       149.211 
OAA non-polymer         . 'OXALOACETATE ION' ? 'C4 H3 O5 -1'         131.064 
PHE 'L-peptide linking' y PHENYLALANINE      ? 'C9 H11 N O2'         165.189 
PRO 'L-peptide linking' y PROLINE            ? 'C5 H9 N O2'          115.130 
SER 'L-peptide linking' y SERINE             ? 'C3 H7 N O3'          105.093 
THR 'L-peptide linking' y THREONINE          ? 'C4 H9 N O3'          119.119 
TRP 'L-peptide linking' y TRYPTOPHAN         ? 'C11 H12 N2 O2'       204.225 
TYR 'L-peptide linking' y TYROSINE           ? 'C9 H11 N O3'         181.189 
VAL 'L-peptide linking' y VALINE             ? 'C5 H11 N O2'         117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   28  ?   ?   ?   A . n 
A 1 2   SER 2   29  ?   ?   ?   A . n 
A 1 3   SER 3   30  30  SER SER A . n 
A 1 4   THR 4   31  31  THR THR A . n 
A 1 5   ASN 5   32  32  ASN ASN A . n 
A 1 6   LEU 6   33  33  LEU LEU A . n 
A 1 7   LYS 7   34  34  LYS LYS A . n 
A 1 8   ASP 8   35  35  ASP ASP A . n 
A 1 9   ILE 9   36  36  ILE ILE A . n 
A 1 10  LEU 10  37  37  LEU LEU A . n 
A 1 11  ALA 11  38  38  ALA ALA A . n 
A 1 12  ASP 12  39  39  ASP ASP A . n 
A 1 13  LEU 13  40  40  LEU LEU A . n 
A 1 14  ILE 14  41  41  ILE ILE A . n 
A 1 15  PRO 15  42  42  PRO PRO A . n 
A 1 16  LYS 16  43  43  LYS LYS A . n 
A 1 17  GLU 17  44  44  GLU GLU A . n 
A 1 18  GLN 18  45  45  GLN GLN A . n 
A 1 19  ALA 19  46  46  ALA ALA A . n 
A 1 20  ARG 20  47  47  ARG ARG A . n 
A 1 21  ILE 21  48  48  ILE ILE A . n 
A 1 22  LYS 22  49  49  LYS LYS A . n 
A 1 23  THR 23  50  50  THR THR A . n 
A 1 24  PHE 24  51  51  PHE PHE A . n 
A 1 25  ARG 25  52  52  ARG ARG A . n 
A 1 26  GLN 26  53  53  GLN GLN A . n 
A 1 27  GLN 27  54  54  GLN GLN A . n 
A 1 28  HIS 28  55  55  HIS HIS A . n 
A 1 29  GLY 29  56  56  GLY GLY A . n 
A 1 30  LYS 30  57  57  LYS LYS A . n 
A 1 31  THR 31  58  58  THR THR A . n 
A 1 32  VAL 32  59  59  VAL VAL A . n 
A 1 33  VAL 33  60  60  VAL VAL A . n 
A 1 34  GLY 34  61  61  GLY GLY A . n 
A 1 35  GLN 35  62  62  GLN GLN A . n 
A 1 36  ILE 36  63  63  ILE ILE A . n 
A 1 37  THR 37  64  64  THR THR A . n 
A 1 38  VAL 38  65  65  VAL VAL A . n 
A 1 39  ASP 39  66  66  ASP ASP A . n 
A 1 40  MET 40  67  67  MET MET A . n 
A 1 41  MET 41  68  68  MET MET A . n 
A 1 42  TYR 42  69  69  TYR TYR A . n 
A 1 43  GLY 43  70  70  GLY GLY A . n 
A 1 44  GLY 44  71  71  GLY GLY A . n 
A 1 45  MET 45  72  72  MET MET A . n 
A 1 46  ARG 46  73  73  ARG ARG A . n 
A 1 47  GLY 47  74  74  GLY GLY A . n 
A 1 48  MET 48  75  75  MET MET A . n 
A 1 49  LYS 49  76  76  LYS LYS A . n 
A 1 50  GLY 50  77  77  GLY GLY A . n 
A 1 51  LEU 51  78  78  LEU LEU A . n 
A 1 52  VAL 52  79  79  VAL VAL A . n 
A 1 53  TYR 53  80  80  TYR TYR A . n 
A 1 54  GLU 54  81  81  GLU GLU A . n 
A 1 55  THR 55  82  82  THR THR A . n 
A 1 56  SER 56  83  83  SER SER A . n 
A 1 57  VAL 57  84  84  VAL VAL A . n 
A 1 58  LEU 58  85  85  LEU LEU A . n 
A 1 59  ASP 59  86  86  ASP ASP A . n 
A 1 60  PRO 60  87  87  PRO PRO A . n 
A 1 61  ASP 61  88  88  ASP ASP A . n 
A 1 62  GLU 62  89  89  GLU GLU A . n 
A 1 63  GLY 63  90  90  GLY GLY A . n 
A 1 64  ILE 64  91  91  ILE ILE A . n 
A 1 65  ARG 65  92  92  ARG ARG A . n 
A 1 66  PHE 66  93  93  PHE PHE A . n 
A 1 67  ARG 67  94  94  ARG ARG A . n 
A 1 68  GLY 68  95  95  GLY GLY A . n 
A 1 69  PHE 69  96  96  PHE PHE A . n 
A 1 70  SER 70  97  97  SER SER A . n 
A 1 71  ILE 71  98  98  ILE ILE A . n 
A 1 72  PRO 72  99  99  PRO PRO A . n 
A 1 73  GLU 73  100 100 GLU GLU A . n 
A 1 74  CYS 74  101 101 CYS CYS A . n 
A 1 75  GLN 75  102 102 GLN GLN A . n 
A 1 76  LYS 76  103 103 LYS LYS A . n 
A 1 77  LEU 77  104 104 LEU LEU A . n 
A 1 78  LEU 78  105 105 LEU LEU A . n 
A 1 79  PRO 79  106 106 PRO PRO A . n 
A 1 80  LYS 80  107 107 LYS LYS A . n 
A 1 81  ALA 81  108 108 ALA ALA A . n 
A 1 82  LYS 82  109 109 LYS LYS A . n 
A 1 83  GLY 83  110 110 GLY GLY A . n 
A 1 84  GLY 84  111 111 GLY GLY A . n 
A 1 85  GLU 85  112 112 GLU GLU A . n 
A 1 86  GLU 86  113 113 GLU GLU A . n 
A 1 87  PRO 87  114 114 PRO PRO A . n 
A 1 88  LEU 88  115 115 LEU LEU A . n 
A 1 89  PRO 89  116 116 PRO PRO A . n 
A 1 90  GLU 90  117 117 GLU GLU A . n 
A 1 91  GLY 91  118 118 GLY GLY A . n 
A 1 92  LEU 92  119 119 LEU LEU A . n 
A 1 93  PHE 93  120 120 PHE PHE A . n 
A 1 94  TRP 94  121 121 TRP TRP A . n 
A 1 95  LEU 95  122 122 LEU LEU A . n 
A 1 96  LEU 96  123 123 LEU LEU A . n 
A 1 97  VAL 97  124 124 VAL VAL A . n 
A 1 98  THR 98  125 125 THR THR A . n 
A 1 99  GLY 99  126 126 GLY GLY A . n 
A 1 100 HIS 100 127 127 HIS HIS A . n 
A 1 101 ILE 101 128 128 ILE ILE A . n 
A 1 102 PRO 102 129 129 PRO PRO A . n 
A 1 103 THR 103 130 130 THR THR A . n 
A 1 104 GLU 104 131 131 GLU GLU A . n 
A 1 105 GLU 105 132 132 GLU GLU A . n 
A 1 106 GLN 106 133 133 GLN GLN A . n 
A 1 107 VAL 107 134 134 VAL VAL A . n 
A 1 108 SER 108 135 135 SER SER A . n 
A 1 109 TRP 109 136 136 TRP TRP A . n 
A 1 110 LEU 110 137 137 LEU LEU A . n 
A 1 111 SER 111 138 138 SER SER A . n 
A 1 112 LYS 112 139 139 LYS LYS A . n 
A 1 113 GLU 113 140 140 GLU GLU A . n 
A 1 114 TRP 114 141 141 TRP TRP A . n 
A 1 115 ALA 115 142 142 ALA ALA A . n 
A 1 116 LYS 116 143 143 LYS LYS A . n 
A 1 117 ARG 117 144 144 ARG ARG A . n 
A 1 118 ALA 118 145 145 ALA ALA A . n 
A 1 119 ALA 119 146 146 ALA ALA A . n 
A 1 120 LEU 120 147 147 LEU LEU A . n 
A 1 121 PRO 121 148 148 PRO PRO A . n 
A 1 122 SER 122 149 149 SER SER A . n 
A 1 123 HIS 123 150 150 HIS HIS A . n 
A 1 124 VAL 124 151 151 VAL VAL A . n 
A 1 125 VAL 125 152 152 VAL VAL A . n 
A 1 126 THR 126 153 153 THR THR A . n 
A 1 127 MET 127 154 154 MET MET A . n 
A 1 128 LEU 128 155 155 LEU LEU A . n 
A 1 129 ASP 129 156 156 ASP ASP A . n 
A 1 130 ASN 130 157 157 ASN ASN A . n 
A 1 131 PHE 131 158 158 PHE PHE A . n 
A 1 132 PRO 132 159 159 PRO PRO A . n 
A 1 133 THR 133 160 160 THR THR A . n 
A 1 134 ASN 134 161 161 ASN ASN A . n 
A 1 135 LEU 135 162 162 LEU LEU A . n 
A 1 136 HIS 136 163 163 HIS HIS A . n 
A 1 137 PRO 137 164 164 PRO PRO A . n 
A 1 138 MET 138 165 165 MET MET A . n 
A 1 139 SER 139 166 166 SER SER A . n 
A 1 140 GLN 140 167 167 GLN GLN A . n 
A 1 141 LEU 141 168 168 LEU LEU A . n 
A 1 142 SER 142 169 169 SER SER A . n 
A 1 143 ALA 143 170 170 ALA ALA A . n 
A 1 144 ALA 144 171 171 ALA ALA A . n 
A 1 145 VAL 145 172 172 VAL VAL A . n 
A 1 146 THR 146 173 173 THR THR A . n 
A 1 147 ALA 147 174 174 ALA ALA A . n 
A 1 148 LEU 148 175 175 LEU LEU A . n 
A 1 149 ASN 149 176 176 ASN ASN A . n 
A 1 150 SER 150 177 177 SER SER A . n 
A 1 151 GLU 151 178 178 GLU GLU A . n 
A 1 152 SER 152 179 179 SER SER A . n 
A 1 153 ASN 153 180 180 ASN ASN A . n 
A 1 154 PHE 154 181 181 PHE PHE A . n 
A 1 155 ALA 155 182 182 ALA ALA A . n 
A 1 156 ARG 156 183 183 ARG ARG A . n 
A 1 157 ALA 157 184 184 ALA ALA A . n 
A 1 158 TYR 158 185 185 TYR TYR A . n 
A 1 159 ALA 159 186 186 ALA ALA A . n 
A 1 160 GLN 160 187 187 GLN GLN A . n 
A 1 161 GLY 161 188 188 GLY GLY A . n 
A 1 162 ILE 162 189 189 ILE ILE A . n 
A 1 163 SER 163 190 190 SER SER A . n 
A 1 164 ARG 164 191 191 ARG ARG A . n 
A 1 165 THR 165 192 192 THR THR A . n 
A 1 166 LYS 166 193 193 LYS LYS A . n 
A 1 167 TYR 167 194 194 TYR TYR A . n 
A 1 168 TRP 168 195 195 TRP TRP A . n 
A 1 169 GLU 169 196 196 GLU GLU A . n 
A 1 170 LEU 170 197 197 LEU LEU A . n 
A 1 171 ILE 171 198 198 ILE ILE A . n 
A 1 172 TYR 172 199 199 TYR TYR A . n 
A 1 173 GLU 173 200 200 GLU GLU A . n 
A 1 174 ASP 174 201 201 ASP ASP A . n 
A 1 175 SER 175 202 202 SER SER A . n 
A 1 176 MET 176 203 203 MET MET A . n 
A 1 177 ASP 177 204 204 ASP ASP A . n 
A 1 178 LEU 178 205 205 LEU LEU A . n 
A 1 179 ILE 179 206 206 ILE ILE A . n 
A 1 180 ALA 180 207 207 ALA ALA A . n 
A 1 181 LYS 181 208 208 LYS LYS A . n 
A 1 182 LEU 182 209 209 LEU LEU A . n 
A 1 183 PRO 183 210 210 PRO PRO A . n 
A 1 184 CYS 184 211 211 CYS CYS A . n 
A 1 185 VAL 185 212 212 VAL VAL A . n 
A 1 186 ALA 186 213 213 ALA ALA A . n 
A 1 187 ALA 187 214 214 ALA ALA A . n 
A 1 188 LYS 188 215 215 LYS LYS A . n 
A 1 189 ILE 189 216 216 ILE ILE A . n 
A 1 190 TYR 190 217 217 TYR TYR A . n 
A 1 191 ARG 191 218 218 ARG ARG A . n 
A 1 192 ASN 192 219 219 ASN ASN A . n 
A 1 193 LEU 193 220 220 LEU LEU A . n 
A 1 194 TYR 194 221 221 TYR TYR A . n 
A 1 195 ARG 195 222 222 ARG ARG A . n 
A 1 196 GLU 196 223 223 GLU GLU A . n 
A 1 197 GLY 197 224 224 GLY GLY A . n 
A 1 198 SER 198 225 225 SER SER A . n 
A 1 199 GLY 199 226 226 GLY GLY A . n 
A 1 200 ILE 200 227 227 ILE ILE A . n 
A 1 201 GLY 201 228 228 GLY GLY A . n 
A 1 202 ALA 202 229 229 ALA ALA A . n 
A 1 203 ILE 203 230 230 ILE ILE A . n 
A 1 204 ASP 204 231 231 ASP ASP A . n 
A 1 205 SER 205 232 232 SER SER A . n 
A 1 206 ASN 206 233 233 ASN ASN A . n 
A 1 207 LEU 207 234 234 LEU LEU A . n 
A 1 208 ASP 208 235 235 ASP ASP A . n 
A 1 209 TRP 209 236 236 TRP TRP A . n 
A 1 210 SER 210 237 237 SER SER A . n 
A 1 211 HIS 211 238 238 HIS HIS A . n 
A 1 212 ASN 212 239 239 ASN ASN A . n 
A 1 213 PHE 213 240 240 PHE PHE A . n 
A 1 214 THR 214 241 241 THR THR A . n 
A 1 215 ASN 215 242 242 ASN ASN A . n 
A 1 216 MET 216 243 243 MET MET A . n 
A 1 217 LEU 217 244 244 LEU LEU A . n 
A 1 218 GLY 218 245 245 GLY GLY A . n 
A 1 219 TYR 219 246 246 TYR TYR A . n 
A 1 220 THR 220 247 247 THR THR A . n 
A 1 221 ASP 221 248 248 ASP ASP A . n 
A 1 222 HIS 222 249 249 HIS HIS A . n 
A 1 223 GLN 223 250 250 GLN GLN A . n 
A 1 224 PHE 224 251 251 PHE PHE A . n 
A 1 225 THR 225 252 252 THR THR A . n 
A 1 226 GLU 226 253 253 GLU GLU A . n 
A 1 227 LEU 227 254 254 LEU LEU A . n 
A 1 228 THR 228 255 255 THR THR A . n 
A 1 229 ARG 229 256 256 ARG ARG A . n 
A 1 230 LEU 230 257 257 LEU LEU A . n 
A 1 231 TYR 231 258 258 TYR TYR A . n 
A 1 232 LEU 232 259 259 LEU LEU A . n 
A 1 233 THR 233 260 260 THR THR A . n 
A 1 234 ILE 234 261 261 ILE ILE A . n 
A 1 235 HIS 235 262 262 HIS HIS A . n 
A 1 236 SER 236 263 263 SER SER A . n 
A 1 237 ASP 237 264 264 ASP ASP A . n 
A 1 238 HIS 238 265 265 HIS HIS A . n 
A 1 239 GLU 239 266 266 GLU GLU A . n 
A 1 240 GLY 240 267 267 GLY GLY A . n 
A 1 241 GLY 241 268 268 GLY GLY A . n 
A 1 242 ASN 242 269 269 ASN ASN A . n 
A 1 243 VAL 243 270 270 VAL VAL A . n 
A 1 244 SER 244 271 271 SER SER A . n 
A 1 245 ALA 245 272 272 ALA ALA A . n 
A 1 246 HIS 246 273 273 HIS HIS A . n 
A 1 247 THR 247 274 274 THR THR A . n 
A 1 248 SER 248 275 275 SER SER A . n 
A 1 249 HIS 249 276 276 HIS HIS A . n 
A 1 250 LEU 250 277 277 LEU LEU A . n 
A 1 251 VAL 251 278 278 VAL VAL A . n 
A 1 252 GLY 252 279 279 GLY GLY A . n 
A 1 253 SER 253 280 280 SER SER A . n 
A 1 254 ALA 254 281 281 ALA ALA A . n 
A 1 255 LEU 255 282 282 LEU LEU A . n 
A 1 256 SER 256 283 283 SER SER A . n 
A 1 257 ASP 257 284 284 ASP ASP A . n 
A 1 258 PRO 258 285 285 PRO PRO A . n 
A 1 259 TYR 259 286 286 TYR TYR A . n 
A 1 260 LEU 260 287 287 LEU LEU A . n 
A 1 261 SER 261 288 288 SER SER A . n 
A 1 262 PHE 262 289 289 PHE PHE A . n 
A 1 263 ALA 263 290 290 ALA ALA A . n 
A 1 264 ALA 264 291 291 ALA ALA A . n 
A 1 265 ALA 265 292 292 ALA ALA A . n 
A 1 266 MET 266 293 293 MET MET A . n 
A 1 267 ASN 267 294 294 ASN ASN A . n 
A 1 268 GLY 268 295 295 GLY GLY A . n 
A 1 269 LEU 269 296 296 LEU LEU A . n 
A 1 270 ALA 270 297 297 ALA ALA A . n 
A 1 271 GLY 271 298 298 GLY GLY A . n 
A 1 272 PRO 272 299 299 PRO PRO A . n 
A 1 273 LEU 273 300 300 LEU LEU A . n 
A 1 274 HIS 274 301 301 HIS HIS A . n 
A 1 275 GLY 275 302 302 GLY GLY A . n 
A 1 276 LEU 276 303 303 LEU LEU A . n 
A 1 277 ALA 277 304 304 ALA ALA A . n 
A 1 278 ASN 278 305 305 ASN ASN A . n 
A 1 279 GLN 279 306 306 GLN GLN A . n 
A 1 280 GLU 280 307 307 GLU GLU A . n 
A 1 281 VAL 281 308 308 VAL VAL A . n 
A 1 282 LEU 282 309 309 LEU LEU A . n 
A 1 283 VAL 283 310 310 VAL VAL A . n 
A 1 284 TRP 284 311 311 TRP TRP A . n 
A 1 285 LEU 285 312 312 LEU LEU A . n 
A 1 286 THR 286 313 313 THR THR A . n 
A 1 287 GLN 287 314 314 GLN GLN A . n 
A 1 288 LEU 288 315 315 LEU LEU A . n 
A 1 289 GLN 289 316 316 GLN GLN A . n 
A 1 290 LYS 290 317 317 LYS LYS A . n 
A 1 291 GLU 291 318 318 GLU GLU A . n 
A 1 292 VAL 292 319 319 VAL VAL A . n 
A 1 293 GLY 293 320 320 GLY GLY A . n 
A 1 294 LYS 294 321 321 LYS LYS A . n 
A 1 295 ASP 295 322 322 ASP ASP A . n 
A 1 296 VAL 296 323 323 VAL VAL A . n 
A 1 297 SER 297 324 324 SER SER A . n 
A 1 298 ASP 298 325 325 ASP ASP A . n 
A 1 299 GLU 299 326 326 GLU GLU A . n 
A 1 300 LYS 300 327 327 LYS LYS A . n 
A 1 301 LEU 301 328 328 LEU LEU A . n 
A 1 302 ARG 302 329 329 ARG ARG A . n 
A 1 303 ASP 303 330 330 ASP ASP A . n 
A 1 304 TYR 304 331 331 TYR TYR A . n 
A 1 305 ILE 305 332 332 ILE ILE A . n 
A 1 306 TRP 306 333 333 TRP TRP A . n 
A 1 307 ASN 307 334 334 ASN ASN A . n 
A 1 308 THR 308 335 335 THR THR A . n 
A 1 309 LEU 309 336 336 LEU LEU A . n 
A 1 310 ASN 310 337 337 ASN ASN A . n 
A 1 311 SER 311 338 338 SER SER A . n 
A 1 312 GLY 312 339 339 GLY GLY A . n 
A 1 313 ARG 313 340 340 ARG ARG A . n 
A 1 314 VAL 314 341 341 VAL VAL A . n 
A 1 315 VAL 315 342 342 VAL VAL A . n 
A 1 316 PRO 316 343 343 PRO PRO A . n 
A 1 317 GLY 317 344 344 GLY GLY A . n 
A 1 318 TYR 318 345 345 TYR TYR A . n 
A 1 319 GLY 319 346 346 GLY GLY A . n 
A 1 320 HIS 320 347 347 HIS HIS A . n 
A 1 321 ALA 321 348 348 ALA ALA A . n 
A 1 322 VAL 322 349 349 VAL VAL A . n 
A 1 323 LEU 323 350 350 LEU LEU A . n 
A 1 324 ARG 324 351 351 ARG ARG A . n 
A 1 325 LYS 325 352 352 LYS LYS A . n 
A 1 326 THR 326 353 353 THR THR A . n 
A 1 327 ASP 327 354 354 ASP ASP A . n 
A 1 328 PRO 328 355 355 PRO PRO A . n 
A 1 329 ARG 329 356 356 ARG ARG A . n 
A 1 330 TYR 330 357 357 TYR TYR A . n 
A 1 331 THR 331 358 358 THR THR A . n 
A 1 332 CYS 332 359 359 CYS CYS A . n 
A 1 333 GLN 333 360 360 GLN GLN A . n 
A 1 334 ARG 334 361 361 ARG ARG A . n 
A 1 335 GLU 335 362 362 GLU GLU A . n 
A 1 336 PHE 336 363 363 PHE PHE A . n 
A 1 337 ALA 337 364 364 ALA ALA A . n 
A 1 338 LEU 338 365 365 LEU LEU A . n 
A 1 339 LYS 339 366 366 LYS LYS A . n 
A 1 340 HIS 340 367 367 HIS HIS A . n 
A 1 341 LEU 341 368 368 LEU LEU A . n 
A 1 342 PRO 342 369 369 PRO PRO A . n 
A 1 343 ASN 343 370 370 ASN ASN A . n 
A 1 344 ASP 344 371 371 ASP ASP A . n 
A 1 345 PRO 345 372 372 PRO PRO A . n 
A 1 346 MET 346 373 373 MET MET A . n 
A 1 347 PHE 347 374 374 PHE PHE A . n 
A 1 348 LYS 348 375 375 LYS LYS A . n 
A 1 349 LEU 349 376 376 LEU LEU A . n 
A 1 350 VAL 350 377 377 VAL VAL A . n 
A 1 351 ALA 351 378 378 ALA ALA A . n 
A 1 352 GLN 352 379 379 GLN GLN A . n 
A 1 353 LEU 353 380 380 LEU LEU A . n 
A 1 354 TYR 354 381 381 TYR TYR A . n 
A 1 355 LYS 355 382 382 LYS LYS A . n 
A 1 356 ILE 356 383 383 ILE ILE A . n 
A 1 357 VAL 357 384 384 VAL VAL A . n 
A 1 358 PRO 358 385 385 PRO PRO A . n 
A 1 359 ASN 359 386 386 ASN ASN A . n 
A 1 360 VAL 360 387 387 VAL VAL A . n 
A 1 361 LEU 361 388 388 LEU LEU A . n 
A 1 362 LEU 362 389 389 LEU LEU A . n 
A 1 363 GLU 363 390 390 GLU GLU A . n 
A 1 364 GLN 364 391 391 GLN GLN A . n 
A 1 365 GLY 365 392 392 GLY GLY A . n 
A 1 366 LYS 366 393 393 LYS LYS A . n 
A 1 367 ALA 367 394 394 ALA ALA A . n 
A 1 368 LYS 368 395 395 LYS LYS A . n 
A 1 369 ASN 369 396 396 ASN ASN A . n 
A 1 370 PRO 370 397 397 PRO PRO A . n 
A 1 371 TRP 371 398 398 TRP TRP A . n 
A 1 372 PRO 372 399 399 PRO PRO A . n 
A 1 373 ASN 373 400 400 ASN ASN A . n 
A 1 374 VAL 374 401 401 VAL VAL A . n 
A 1 375 ASP 375 402 402 ASP ASP A . n 
A 1 376 ALA 376 403 403 ALA ALA A . n 
A 1 377 HIS 377 404 404 HIS HIS A . n 
A 1 378 SER 378 405 405 SER SER A . n 
A 1 379 GLY 379 406 406 GLY GLY A . n 
A 1 380 VAL 380 407 407 VAL VAL A . n 
A 1 381 LEU 381 408 408 LEU LEU A . n 
A 1 382 LEU 382 409 409 LEU LEU A . n 
A 1 383 GLN 383 410 410 GLN GLN A . n 
A 1 384 TYR 384 411 411 TYR TYR A . n 
A 1 385 TYR 385 412 412 TYR TYR A . n 
A 1 386 GLY 386 413 413 GLY GLY A . n 
A 1 387 MET 387 414 414 MET MET A . n 
A 1 388 THR 388 415 415 THR THR A . n 
A 1 389 GLU 389 416 416 GLU GLU A . n 
A 1 390 MET 390 417 417 MET MET A . n 
A 1 391 ASN 391 418 418 ASN ASN A . n 
A 1 392 TYR 392 419 419 TYR TYR A . n 
A 1 393 TYR 393 420 420 TYR TYR A . n 
A 1 394 THR 394 421 421 THR THR A . n 
A 1 395 VAL 395 422 422 VAL VAL A . n 
A 1 396 LEU 396 423 423 LEU LEU A . n 
A 1 397 PHE 397 424 424 PHE PHE A . n 
A 1 398 GLY 398 425 425 GLY GLY A . n 
A 1 399 VAL 399 426 426 VAL VAL A . n 
A 1 400 SER 400 427 427 SER SER A . n 
A 1 401 ARG 401 428 428 ARG ARG A . n 
A 1 402 ALA 402 429 429 ALA ALA A . n 
A 1 403 LEU 403 430 430 LEU LEU A . n 
A 1 404 GLY 404 431 431 GLY GLY A . n 
A 1 405 VAL 405 432 432 VAL VAL A . n 
A 1 406 LEU 406 433 433 LEU LEU A . n 
A 1 407 ALA 407 434 434 ALA ALA A . n 
A 1 408 GLN 408 435 435 GLN GLN A . n 
A 1 409 LEU 409 436 436 LEU LEU A . n 
A 1 410 ILE 410 437 437 ILE ILE A . n 
A 1 411 TRP 411 438 438 TRP TRP A . n 
A 1 412 SER 412 439 439 SER SER A . n 
A 1 413 ARG 413 440 440 ARG ARG A . n 
A 1 414 ALA 414 441 441 ALA ALA A . n 
A 1 415 LEU 415 442 442 LEU LEU A . n 
A 1 416 GLY 416 443 443 GLY GLY A . n 
A 1 417 PHE 417 444 444 PHE PHE A . n 
A 1 418 PRO 418 445 445 PRO PRO A . n 
A 1 419 LEU 419 446 446 LEU LEU A . n 
A 1 420 GLU 420 447 447 GLU GLU A . n 
A 1 421 ARG 421 448 448 ARG ARG A . n 
A 1 422 PRO 422 449 449 PRO PRO A . n 
A 1 423 LYS 423 450 450 LYS LYS A . n 
A 1 424 SER 424 451 451 SER SER A . n 
A 1 425 MET 425 452 452 MET MET A . n 
A 1 426 SER 426 453 453 SER SER A . n 
A 1 427 THR 427 454 454 THR THR A . n 
A 1 428 GLU 428 455 455 GLU GLU A . n 
A 1 429 GLY 429 456 456 GLY GLY A . n 
A 1 430 LEU 430 457 457 LEU LEU A . n 
A 1 431 MET 431 458 458 MET MET A . n 
A 1 432 LYS 432 459 459 LYS LYS A . n 
A 1 433 PHE 433 460 460 PHE PHE A . n 
A 1 434 VAL 434 461 461 VAL VAL A . n 
A 1 435 ASP 435 462 462 ASP ASP A . n 
A 1 436 SER 436 463 463 SER SER A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 OAA 1   501 501 OAA OAA A . 
C 3 ACY 1   502 502 ACY ACY A . 
D 4 COA 1   503 502 COA COA A . 
E 5 HOH 1   601 200 HOH HOH A . 
E 5 HOH 2   602 183 HOH HOH A . 
E 5 HOH 3   603 22  HOH HOH A . 
E 5 HOH 4   604 15  HOH HOH A . 
E 5 HOH 5   605 4   HOH HOH A . 
E 5 HOH 6   606 80  HOH HOH A . 
E 5 HOH 7   607 126 HOH HOH A . 
E 5 HOH 8   608 56  HOH HOH A . 
E 5 HOH 9   609 199 HOH HOH A . 
E 5 HOH 10  610 191 HOH HOH A . 
E 5 HOH 11  611 106 HOH HOH A . 
E 5 HOH 12  612 5   HOH HOH A . 
E 5 HOH 13  613 20  HOH HOH A . 
E 5 HOH 14  614 109 HOH HOH A . 
E 5 HOH 15  615 141 HOH HOH A . 
E 5 HOH 16  616 76  HOH HOH A . 
E 5 HOH 17  617 3   HOH HOH A . 
E 5 HOH 18  618 113 HOH HOH A . 
E 5 HOH 19  619 108 HOH HOH A . 
E 5 HOH 20  620 30  HOH HOH A . 
E 5 HOH 21  621 49  HOH HOH A . 
E 5 HOH 22  622 10  HOH HOH A . 
E 5 HOH 23  623 195 HOH HOH A . 
E 5 HOH 24  624 52  HOH HOH A . 
E 5 HOH 25  625 144 HOH HOH A . 
E 5 HOH 26  626 18  HOH HOH A . 
E 5 HOH 27  627 58  HOH HOH A . 
E 5 HOH 28  628 92  HOH HOH A . 
E 5 HOH 29  629 163 HOH HOH A . 
E 5 HOH 30  630 149 HOH HOH A . 
E 5 HOH 31  631 44  HOH HOH A . 
E 5 HOH 32  632 139 HOH HOH A . 
E 5 HOH 33  633 97  HOH HOH A . 
E 5 HOH 34  634 112 HOH HOH A . 
E 5 HOH 35  635 40  HOH HOH A . 
E 5 HOH 36  636 62  HOH HOH A . 
E 5 HOH 37  637 132 HOH HOH A . 
E 5 HOH 38  638 74  HOH HOH A . 
E 5 HOH 39  639 135 HOH HOH A . 
E 5 HOH 40  640 86  HOH HOH A . 
E 5 HOH 41  641 150 HOH HOH A . 
E 5 HOH 42  642 93  HOH HOH A . 
E 5 HOH 43  643 37  HOH HOH A . 
E 5 HOH 44  644 85  HOH HOH A . 
E 5 HOH 45  645 31  HOH HOH A . 
E 5 HOH 46  646 148 HOH HOH A . 
E 5 HOH 47  647 90  HOH HOH A . 
E 5 HOH 48  648 13  HOH HOH A . 
E 5 HOH 49  649 100 HOH HOH A . 
E 5 HOH 50  650 129 HOH HOH A . 
E 5 HOH 51  651 63  HOH HOH A . 
E 5 HOH 52  652 55  HOH HOH A . 
E 5 HOH 53  653 29  HOH HOH A . 
E 5 HOH 54  654 182 HOH HOH A . 
E 5 HOH 55  655 66  HOH HOH A . 
E 5 HOH 56  656 61  HOH HOH A . 
E 5 HOH 57  657 23  HOH HOH A . 
E 5 HOH 58  658 8   HOH HOH A . 
E 5 HOH 59  659 53  HOH HOH A . 
E 5 HOH 60  660 41  HOH HOH A . 
E 5 HOH 61  661 152 HOH HOH A . 
E 5 HOH 62  662 65  HOH HOH A . 
E 5 HOH 63  663 194 HOH HOH A . 
E 5 HOH 64  664 12  HOH HOH A . 
E 5 HOH 65  665 6   HOH HOH A . 
E 5 HOH 66  666 116 HOH HOH A . 
E 5 HOH 67  667 38  HOH HOH A . 
E 5 HOH 68  668 95  HOH HOH A . 
E 5 HOH 69  669 24  HOH HOH A . 
E 5 HOH 70  670 164 HOH HOH A . 
E 5 HOH 71  671 17  HOH HOH A . 
E 5 HOH 72  672 143 HOH HOH A . 
E 5 HOH 73  673 27  HOH HOH A . 
E 5 HOH 74  674 114 HOH HOH A . 
E 5 HOH 75  675 9   HOH HOH A . 
E 5 HOH 76  676 170 HOH HOH A . 
E 5 HOH 77  677 78  HOH HOH A . 
E 5 HOH 78  678 16  HOH HOH A . 
E 5 HOH 79  679 45  HOH HOH A . 
E 5 HOH 80  680 162 HOH HOH A . 
E 5 HOH 81  681 50  HOH HOH A . 
E 5 HOH 82  682 57  HOH HOH A . 
E 5 HOH 83  683 110 HOH HOH A . 
E 5 HOH 84  684 26  HOH HOH A . 
E 5 HOH 85  685 167 HOH HOH A . 
E 5 HOH 86  686 127 HOH HOH A . 
E 5 HOH 87  687 105 HOH HOH A . 
E 5 HOH 88  688 42  HOH HOH A . 
E 5 HOH 89  689 72  HOH HOH A . 
E 5 HOH 90  690 25  HOH HOH A . 
E 5 HOH 91  691 28  HOH HOH A . 
E 5 HOH 92  692 91  HOH HOH A . 
E 5 HOH 93  693 11  HOH HOH A . 
E 5 HOH 94  694 145 HOH HOH A . 
E 5 HOH 95  695 73  HOH HOH A . 
E 5 HOH 96  696 46  HOH HOH A . 
E 5 HOH 97  697 59  HOH HOH A . 
E 5 HOH 98  698 96  HOH HOH A . 
E 5 HOH 99  699 19  HOH HOH A . 
E 5 HOH 100 700 176 HOH HOH A . 
E 5 HOH 101 701 32  HOH HOH A . 
E 5 HOH 102 702 146 HOH HOH A . 
E 5 HOH 103 703 34  HOH HOH A . 
E 5 HOH 104 704 111 HOH HOH A . 
E 5 HOH 105 705 47  HOH HOH A . 
E 5 HOH 106 706 79  HOH HOH A . 
E 5 HOH 107 707 68  HOH HOH A . 
E 5 HOH 108 708 43  HOH HOH A . 
E 5 HOH 109 709 134 HOH HOH A . 
E 5 HOH 110 710 2   HOH HOH A . 
E 5 HOH 111 711 39  HOH HOH A . 
E 5 HOH 112 712 142 HOH HOH A . 
E 5 HOH 113 713 21  HOH HOH A . 
E 5 HOH 114 714 130 HOH HOH A . 
E 5 HOH 115 715 84  HOH HOH A . 
E 5 HOH 116 716 154 HOH HOH A . 
E 5 HOH 117 717 157 HOH HOH A . 
E 5 HOH 118 718 172 HOH HOH A . 
E 5 HOH 119 719 89  HOH HOH A . 
E 5 HOH 120 720 159 HOH HOH A . 
E 5 HOH 121 721 169 HOH HOH A . 
E 5 HOH 122 722 69  HOH HOH A . 
E 5 HOH 123 723 187 HOH HOH A . 
E 5 HOH 124 724 103 HOH HOH A . 
E 5 HOH 125 725 14  HOH HOH A . 
E 5 HOH 126 726 98  HOH HOH A . 
E 5 HOH 127 727 120 HOH HOH A . 
E 5 HOH 128 728 136 HOH HOH A . 
E 5 HOH 129 729 138 HOH HOH A . 
E 5 HOH 130 730 82  HOH HOH A . 
E 5 HOH 131 731 156 HOH HOH A . 
E 5 HOH 132 732 158 HOH HOH A . 
E 5 HOH 133 733 48  HOH HOH A . 
E 5 HOH 134 734 161 HOH HOH A . 
E 5 HOH 135 735 122 HOH HOH A . 
E 5 HOH 136 736 190 HOH HOH A . 
E 5 HOH 137 737 192 HOH HOH A . 
E 5 HOH 138 738 197 HOH HOH A . 
E 5 HOH 139 739 188 HOH HOH A . 
E 5 HOH 140 740 185 HOH HOH A . 
E 5 HOH 141 741 124 HOH HOH A . 
E 5 HOH 142 742 196 HOH HOH A . 
E 5 HOH 143 743 186 HOH HOH A . 
E 5 HOH 144 744 131 HOH HOH A . 
E 5 HOH 145 745 75  HOH HOH A . 
E 5 HOH 146 746 189 HOH HOH A . 
E 5 HOH 147 747 198 HOH HOH A . 
E 5 HOH 148 748 107 HOH HOH A . 
E 5 HOH 149 749 104 HOH HOH A . 
E 5 HOH 150 750 193 HOH HOH A . 
E 5 HOH 151 751 151 HOH HOH A . 
E 5 HOH 152 752 117 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A LYS 215 ? NZ ? A LYS 188 NZ 
2 1 Y 1 A LYS 393 ? CG ? A LYS 366 CG 
3 1 Y 1 A LYS 393 ? CD ? A LYS 366 CD 
4 1 Y 1 A LYS 393 ? CE ? A LYS 366 CE 
5 1 Y 1 A LYS 393 ? NZ ? A LYS 366 NZ 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0419 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZVT 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     57.840 
_cell.length_a_esd                 ? 
_cell.length_b                     57.840 
_cell.length_b_esd                 ? 
_cell.length_c                     250.360 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZVT 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZVT 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.15 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          42.68 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M ammonium acetate pH=7.1, 20% w/v PEG3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-10-26 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL10U2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL10U2 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8ZVT 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.05 
_reflns.d_resolution_low                               31.68 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     27927 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                24.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          12.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.268 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.262 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.05 
_reflns_shell.d_res_low                                     2.10 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2004 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               1.617 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.754 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.586 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.01 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][2]                            0.01 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            -0.01 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               33.257 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.949 
_refine.correlation_coeff_Fo_to_Fc_free          0.898 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZVT 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.05 
_refine.ls_d_res_low                             31.68 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     26468 
_refine.ls_number_reflns_R_free                  1362 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.87 
_refine.ls_percent_reflns_R_free                 4.9 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.20399 
_refine.ls_R_factor_R_free                       0.26936 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20089 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.231 
_refine.pdbx_overall_ESU_R_Free                  0.208 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             5.421 
_refine.overall_SU_ML                            0.145 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.05 
_refine_hist.d_res_low                        31.68 
_refine_hist.number_atoms_solvent             152 
_refine_hist.number_atoms_total               3630 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3430 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         48 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.007  0.012  3571 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  3352 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.630  1.831  4854 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.549  1.747  7724 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 6.598  5.000  435  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 8.896  5.000  22   ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 15.509 10.000 593  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.080  0.200  533  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.007  0.020  4174 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  809  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 2.799  3.222  1738 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 2.798  3.221  1737 ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 4.027  5.782  2170 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 4.026  5.784  2171 ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 3.372  3.655  1833 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 3.372  3.656  1834 ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 5.225  6.539  2684 ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 6.771  32.85  4273 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 6.768  32.73  4256 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.050 
_refine_ls_shell.d_res_low                        2.103 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             127 
_refine_ls_shell.number_reflns_R_work             1870 
_refine_ls_shell.percent_reflns_obs               100.00 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.276 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.284 
# 
_struct.entry_id                     8ZVT 
_struct.title                        'Human citrate synthase intermediate 3' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZVT 
_struct_keywords.text            'citrate synthase, complex, reaction intermediate, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    CISY_HUMAN 
_struct_ref.pdbx_db_accession          O75390 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;ASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPK
AKGGEEPLPEGLFWLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFARAYAQ
GISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTRLYLTIHSDHEG
GNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGH
AVLRKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVS
RALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDS
;
_struct_ref.pdbx_align_begin           28 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8ZVT 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 436 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             O75390 
_struct_ref_seq.db_align_beg                  28 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  463 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       28 
_struct_ref_seq.pdbx_auth_seq_align_end       463 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 11640 ? 
1 MORE         -58   ? 
1 'SSA (A^2)'  30240 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'       1_555 x,y,z 1.0 0.0 0.0 0.0           0.0 1.0 0.0 0.0            0.0 0.0 1.0  0.0 
2 'point symmetry operation' ?     ?     0.0 1.0 0.0 57.8400000000 1.0 0.0 0.0 -57.8400000000 0.0 0.0 -1.0 0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 5   ? GLY A 29  ? ASN A 32  GLY A 56  1 ? 25 
HELX_P HELX_P2  AA2 THR A 37  ? GLY A 43  ? THR A 64  GLY A 70  1 ? 7  
HELX_P HELX_P3  AA3 SER A 70  ? LEU A 78  ? SER A 97  LEU A 105 1 ? 9  
HELX_P HELX_P4  AA4 LEU A 88  ? GLY A 99  ? LEU A 115 GLY A 126 1 ? 12 
HELX_P HELX_P5  AA5 THR A 103 ? ARG A 117 ? THR A 130 ARG A 144 1 ? 15 
HELX_P HELX_P6  AA6 PRO A 121 ? PHE A 131 ? PRO A 148 PHE A 158 1 ? 11 
HELX_P HELX_P7  AA7 HIS A 136 ? LEU A 148 ? HIS A 163 LEU A 175 1 ? 13 
HELX_P HELX_P8  AA8 ASN A 149 ? GLU A 151 ? ASN A 176 GLU A 178 5 ? 3  
HELX_P HELX_P9  AA9 SER A 152 ? GLN A 160 ? SER A 179 GLN A 187 1 ? 9  
HELX_P HELX_P10 AB1 SER A 163 ? THR A 165 ? SER A 190 THR A 192 5 ? 3  
HELX_P HELX_P11 AB2 LYS A 166 ? ARG A 195 ? LYS A 193 ARG A 222 1 ? 30 
HELX_P HELX_P12 AB3 ASP A 208 ? GLY A 218 ? ASP A 235 GLY A 245 1 ? 11 
HELX_P HELX_P13 AB4 ASP A 221 ? HIS A 235 ? ASP A 248 HIS A 262 1 ? 15 
HELX_P HELX_P14 AB5 ASN A 242 ? ALA A 254 ? ASN A 269 ALA A 281 1 ? 13 
HELX_P HELX_P15 AB6 ASP A 257 ? ALA A 270 ? ASP A 284 ALA A 297 1 ? 14 
HELX_P HELX_P16 AB7 GLY A 271 ? LEU A 276 ? GLY A 298 LEU A 303 1 ? 6  
HELX_P HELX_P17 AB8 LEU A 276 ? GLY A 293 ? LEU A 303 GLY A 320 1 ? 18 
HELX_P HELX_P18 AB9 SER A 297 ? SER A 311 ? SER A 324 SER A 338 1 ? 15 
HELX_P HELX_P19 AC1 ASP A 327 ? LEU A 341 ? ASP A 354 LEU A 368 1 ? 15 
HELX_P HELX_P20 AC2 ASP A 344 ? GLU A 363 ? ASP A 371 GLU A 390 1 ? 20 
HELX_P HELX_P21 AC3 VAL A 374 ? TYR A 385 ? VAL A 401 TYR A 412 1 ? 12 
HELX_P HELX_P22 AC4 GLU A 389 ? ASN A 391 ? GLU A 416 ASN A 418 5 ? 3  
HELX_P HELX_P23 AC5 TYR A 392 ? LEU A 415 ? TYR A 419 LEU A 442 1 ? 24 
HELX_P HELX_P24 AC6 SER A 426 ? SER A 436 ? SER A 453 SER A 463 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   2 
_struct_sheet.details          ? 
# 
_struct_sheet_order.sheet_id     AA1 
_struct_sheet_order.range_id_1   1 
_struct_sheet_order.range_id_2   2 
_struct_sheet_order.offset       ? 
_struct_sheet_order.sense        anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 SER A 56 ? ASP A 59 ? SER A 83 ASP A 86 
AA1 2 GLY A 63 ? PHE A 66 ? GLY A 90 PHE A 93 
# 
_pdbx_struct_sheet_hbond.sheet_id                AA1 
_pdbx_struct_sheet_hbond.range_id_1              1 
_pdbx_struct_sheet_hbond.range_id_2              2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id   N 
_pdbx_struct_sheet_hbond.range_1_label_comp_id   ASP 
_pdbx_struct_sheet_hbond.range_1_label_asym_id   A 
_pdbx_struct_sheet_hbond.range_1_label_seq_id    59 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code    ? 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id    N 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id    ASP 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id    A 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id     86 
_pdbx_struct_sheet_hbond.range_2_label_atom_id   O 
_pdbx_struct_sheet_hbond.range_2_label_comp_id   GLY 
_pdbx_struct_sheet_hbond.range_2_label_asym_id   A 
_pdbx_struct_sheet_hbond.range_2_label_seq_id    63 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code    ? 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id    O 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id    GLY 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id    A 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id     90 
# 
_pdbx_entry_details.entry_id                   8ZVT 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O3 A OAA 501 ? ? OXT A ACY 502 ? ? 1.95 
2 1 O  A VAL 384 ? ? O   A VAL 387 ? ? 1.96 
3 1 C3 A OAA 501 ? ? CH3 A ACY 502 ? ? 2.07 
4 1 O  A GLU 326 ? ? OD1 A ASP 330 ? ? 2.11 
5 1 O  A GLN 102 ? ? NZ  A LYS 107 ? ? 2.18 
6 1 O3 A OAA 501 ? ? C   A ACY 502 ? ? 2.19 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 NE A ARG 218 ? ? CZ A ARG 218 ? ? NH2 A ARG 218 ? ? 116.66 120.30 -3.64 0.50 N 
2 1 CG A MET 414 ? ? SD A MET 414 ? ? CE  A MET 414 ? ? 110.08 100.20 9.88  1.60 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 GLU A 223 ? ? 47.53   28.45   
2  1 HIS A 265 ? ? -145.30 56.81   
3  1 GLU A 266 ? ? 69.57   -169.80 
4  1 ARG A 351 ? ? -143.14 20.90   
5  1 LEU A 368 ? ? -155.89 57.73   
6  1 LEU A 388 ? ? 103.01  -43.65  
7  1 LYS A 393 ? ? -28.23  110.63  
8  1 ALA A 394 ? ? 179.85  -37.35  
9  1 LYS A 395 ? ? 60.96   -64.44  
10 1 ARG A 448 ? ? -151.38 71.83   
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 361 ? ? 0.086 'SIDE CHAIN' 
2 1 ARG A 448 ? ? 0.128 'SIDE CHAIN' 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 712 ? E HOH . 
2 1 A HOH 721 ? E HOH . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A ALA 28 ? A ALA 1 
2 1 Y 1 A SER 29 ? A SER 2 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ACY C    C N N 1   
ACY O    O N N 2   
ACY OXT  O N N 3   
ACY CH3  C N N 4   
ACY HXT  H N N 5   
ACY H1   H N N 6   
ACY H2   H N N 7   
ACY H3   H N N 8   
ALA N    N N N 9   
ALA CA   C N S 10  
ALA C    C N N 11  
ALA O    O N N 12  
ALA CB   C N N 13  
ALA OXT  O N N 14  
ALA H    H N N 15  
ALA H2   H N N 16  
ALA HA   H N N 17  
ALA HB1  H N N 18  
ALA HB2  H N N 19  
ALA HB3  H N N 20  
ALA HXT  H N N 21  
ARG N    N N N 22  
ARG CA   C N S 23  
ARG C    C N N 24  
ARG O    O N N 25  
ARG CB   C N N 26  
ARG CG   C N N 27  
ARG CD   C N N 28  
ARG NE   N N N 29  
ARG CZ   C N N 30  
ARG NH1  N N N 31  
ARG NH2  N N N 32  
ARG OXT  O N N 33  
ARG H    H N N 34  
ARG H2   H N N 35  
ARG HA   H N N 36  
ARG HB2  H N N 37  
ARG HB3  H N N 38  
ARG HG2  H N N 39  
ARG HG3  H N N 40  
ARG HD2  H N N 41  
ARG HD3  H N N 42  
ARG HE   H N N 43  
ARG HH11 H N N 44  
ARG HH12 H N N 45  
ARG HH21 H N N 46  
ARG HH22 H N N 47  
ARG HXT  H N N 48  
ASN N    N N N 49  
ASN CA   C N S 50  
ASN C    C N N 51  
ASN O    O N N 52  
ASN CB   C N N 53  
ASN CG   C N N 54  
ASN OD1  O N N 55  
ASN ND2  N N N 56  
ASN OXT  O N N 57  
ASN H    H N N 58  
ASN H2   H N N 59  
ASN HA   H N N 60  
ASN HB2  H N N 61  
ASN HB3  H N N 62  
ASN HD21 H N N 63  
ASN HD22 H N N 64  
ASN HXT  H N N 65  
ASP N    N N N 66  
ASP CA   C N S 67  
ASP C    C N N 68  
ASP O    O N N 69  
ASP CB   C N N 70  
ASP CG   C N N 71  
ASP OD1  O N N 72  
ASP OD2  O N N 73  
ASP OXT  O N N 74  
ASP H    H N N 75  
ASP H2   H N N 76  
ASP HA   H N N 77  
ASP HB2  H N N 78  
ASP HB3  H N N 79  
ASP HD2  H N N 80  
ASP HXT  H N N 81  
COA N1A  N Y N 82  
COA C2A  C Y N 83  
COA N3A  N Y N 84  
COA C4A  C Y N 85  
COA C5A  C Y N 86  
COA C6A  C Y N 87  
COA N6A  N N N 88  
COA N7A  N Y N 89  
COA C8A  C Y N 90  
COA N9A  N Y N 91  
COA C1B  C N R 92  
COA C2B  C N R 93  
COA O2B  O N N 94  
COA C3B  C N S 95  
COA O3B  O N N 96  
COA P3B  P N N 97  
COA O7A  O N N 98  
COA O8A  O N N 99  
COA O9A  O N N 100 
COA C4B  C N R 101 
COA O4B  O N N 102 
COA C5B  C N N 103 
COA O5B  O N N 104 
COA P1A  P N S 105 
COA O1A  O N N 106 
COA O2A  O N N 107 
COA O3A  O N N 108 
COA P2A  P N S 109 
COA O4A  O N N 110 
COA O5A  O N N 111 
COA O6A  O N N 112 
COA CBP  C N N 113 
COA CCP  C N N 114 
COA CDP  C N N 115 
COA CEP  C N N 116 
COA CAP  C N R 117 
COA OAP  O N N 118 
COA C9P  C N N 119 
COA O9P  O N N 120 
COA N8P  N N N 121 
COA C7P  C N N 122 
COA C6P  C N N 123 
COA C5P  C N N 124 
COA O5P  O N N 125 
COA N4P  N N N 126 
COA C3P  C N N 127 
COA C2P  C N N 128 
COA S1P  S N N 129 
COA H2A  H N N 130 
COA H61A H N N 131 
COA H62A H N N 132 
COA H8A  H N N 133 
COA H1B  H N N 134 
COA H2B  H N N 135 
COA HO2A H N N 136 
COA H3B  H N N 137 
COA HOA8 H N N 138 
COA HOA9 H N N 139 
COA H4B  H N N 140 
COA H51A H N N 141 
COA H52A H N N 142 
COA HOA2 H N N 143 
COA HOA5 H N N 144 
COA H121 H N N 145 
COA H122 H N N 146 
COA H131 H N N 147 
COA H132 H N N 148 
COA H133 H N N 149 
COA H141 H N N 150 
COA H142 H N N 151 
COA H143 H N N 152 
COA H10  H N N 153 
COA HO1  H N N 154 
COA HN8  H N N 155 
COA H71  H N N 156 
COA H72  H N N 157 
COA H61  H N N 158 
COA H62  H N N 159 
COA HN4  H N N 160 
COA H31  H N N 161 
COA H32  H N N 162 
COA H21  H N N 163 
COA H22  H N N 164 
COA HS1  H N N 165 
CYS N    N N N 166 
CYS CA   C N R 167 
CYS C    C N N 168 
CYS O    O N N 169 
CYS CB   C N N 170 
CYS SG   S N N 171 
CYS OXT  O N N 172 
CYS H    H N N 173 
CYS H2   H N N 174 
CYS HA   H N N 175 
CYS HB2  H N N 176 
CYS HB3  H N N 177 
CYS HG   H N N 178 
CYS HXT  H N N 179 
GLN N    N N N 180 
GLN CA   C N S 181 
GLN C    C N N 182 
GLN O    O N N 183 
GLN CB   C N N 184 
GLN CG   C N N 185 
GLN CD   C N N 186 
GLN OE1  O N N 187 
GLN NE2  N N N 188 
GLN OXT  O N N 189 
GLN H    H N N 190 
GLN H2   H N N 191 
GLN HA   H N N 192 
GLN HB2  H N N 193 
GLN HB3  H N N 194 
GLN HG2  H N N 195 
GLN HG3  H N N 196 
GLN HE21 H N N 197 
GLN HE22 H N N 198 
GLN HXT  H N N 199 
GLU N    N N N 200 
GLU CA   C N S 201 
GLU C    C N N 202 
GLU O    O N N 203 
GLU CB   C N N 204 
GLU CG   C N N 205 
GLU CD   C N N 206 
GLU OE1  O N N 207 
GLU OE2  O N N 208 
GLU OXT  O N N 209 
GLU H    H N N 210 
GLU H2   H N N 211 
GLU HA   H N N 212 
GLU HB2  H N N 213 
GLU HB3  H N N 214 
GLU HG2  H N N 215 
GLU HG3  H N N 216 
GLU HE2  H N N 217 
GLU HXT  H N N 218 
GLY N    N N N 219 
GLY CA   C N N 220 
GLY C    C N N 221 
GLY O    O N N 222 
GLY OXT  O N N 223 
GLY H    H N N 224 
GLY H2   H N N 225 
GLY HA2  H N N 226 
GLY HA3  H N N 227 
GLY HXT  H N N 228 
HIS N    N N N 229 
HIS CA   C N S 230 
HIS C    C N N 231 
HIS O    O N N 232 
HIS CB   C N N 233 
HIS CG   C Y N 234 
HIS ND1  N Y N 235 
HIS CD2  C Y N 236 
HIS CE1  C Y N 237 
HIS NE2  N Y N 238 
HIS OXT  O N N 239 
HIS H    H N N 240 
HIS H2   H N N 241 
HIS HA   H N N 242 
HIS HB2  H N N 243 
HIS HB3  H N N 244 
HIS HD1  H N N 245 
HIS HD2  H N N 246 
HIS HE1  H N N 247 
HIS HE2  H N N 248 
HIS HXT  H N N 249 
HOH O    O N N 250 
HOH H1   H N N 251 
HOH H2   H N N 252 
ILE N    N N N 253 
ILE CA   C N S 254 
ILE C    C N N 255 
ILE O    O N N 256 
ILE CB   C N S 257 
ILE CG1  C N N 258 
ILE CG2  C N N 259 
ILE CD1  C N N 260 
ILE OXT  O N N 261 
ILE H    H N N 262 
ILE H2   H N N 263 
ILE HA   H N N 264 
ILE HB   H N N 265 
ILE HG12 H N N 266 
ILE HG13 H N N 267 
ILE HG21 H N N 268 
ILE HG22 H N N 269 
ILE HG23 H N N 270 
ILE HD11 H N N 271 
ILE HD12 H N N 272 
ILE HD13 H N N 273 
ILE HXT  H N N 274 
LEU N    N N N 275 
LEU CA   C N S 276 
LEU C    C N N 277 
LEU O    O N N 278 
LEU CB   C N N 279 
LEU CG   C N N 280 
LEU CD1  C N N 281 
LEU CD2  C N N 282 
LEU OXT  O N N 283 
LEU H    H N N 284 
LEU H2   H N N 285 
LEU HA   H N N 286 
LEU HB2  H N N 287 
LEU HB3  H N N 288 
LEU HG   H N N 289 
LEU HD11 H N N 290 
LEU HD12 H N N 291 
LEU HD13 H N N 292 
LEU HD21 H N N 293 
LEU HD22 H N N 294 
LEU HD23 H N N 295 
LEU HXT  H N N 296 
LYS N    N N N 297 
LYS CA   C N S 298 
LYS C    C N N 299 
LYS O    O N N 300 
LYS CB   C N N 301 
LYS CG   C N N 302 
LYS CD   C N N 303 
LYS CE   C N N 304 
LYS NZ   N N N 305 
LYS OXT  O N N 306 
LYS H    H N N 307 
LYS H2   H N N 308 
LYS HA   H N N 309 
LYS HB2  H N N 310 
LYS HB3  H N N 311 
LYS HG2  H N N 312 
LYS HG3  H N N 313 
LYS HD2  H N N 314 
LYS HD3  H N N 315 
LYS HE2  H N N 316 
LYS HE3  H N N 317 
LYS HZ1  H N N 318 
LYS HZ2  H N N 319 
LYS HZ3  H N N 320 
LYS HXT  H N N 321 
MET N    N N N 322 
MET CA   C N S 323 
MET C    C N N 324 
MET O    O N N 325 
MET CB   C N N 326 
MET CG   C N N 327 
MET SD   S N N 328 
MET CE   C N N 329 
MET OXT  O N N 330 
MET H    H N N 331 
MET H2   H N N 332 
MET HA   H N N 333 
MET HB2  H N N 334 
MET HB3  H N N 335 
MET HG2  H N N 336 
MET HG3  H N N 337 
MET HE1  H N N 338 
MET HE2  H N N 339 
MET HE3  H N N 340 
MET HXT  H N N 341 
OAA O1   O N N 342 
OAA O2   O N N 343 
OAA O4   O N N 344 
OAA O5   O N N 345 
OAA O3   O N N 346 
OAA C1   C N N 347 
OAA C2   C N N 348 
OAA C3   C N N 349 
OAA C4   C N N 350 
OAA HO5  H N N 351 
OAA H21  H N N 352 
OAA H22  H N N 353 
PHE N    N N N 354 
PHE CA   C N S 355 
PHE C    C N N 356 
PHE O    O N N 357 
PHE CB   C N N 358 
PHE CG   C Y N 359 
PHE CD1  C Y N 360 
PHE CD2  C Y N 361 
PHE CE1  C Y N 362 
PHE CE2  C Y N 363 
PHE CZ   C Y N 364 
PHE OXT  O N N 365 
PHE H    H N N 366 
PHE H2   H N N 367 
PHE HA   H N N 368 
PHE HB2  H N N 369 
PHE HB3  H N N 370 
PHE HD1  H N N 371 
PHE HD2  H N N 372 
PHE HE1  H N N 373 
PHE HE2  H N N 374 
PHE HZ   H N N 375 
PHE HXT  H N N 376 
PRO N    N N N 377 
PRO CA   C N S 378 
PRO C    C N N 379 
PRO O    O N N 380 
PRO CB   C N N 381 
PRO CG   C N N 382 
PRO CD   C N N 383 
PRO OXT  O N N 384 
PRO H    H N N 385 
PRO HA   H N N 386 
PRO HB2  H N N 387 
PRO HB3  H N N 388 
PRO HG2  H N N 389 
PRO HG3  H N N 390 
PRO HD2  H N N 391 
PRO HD3  H N N 392 
PRO HXT  H N N 393 
SER N    N N N 394 
SER CA   C N S 395 
SER C    C N N 396 
SER O    O N N 397 
SER CB   C N N 398 
SER OG   O N N 399 
SER OXT  O N N 400 
SER H    H N N 401 
SER H2   H N N 402 
SER HA   H N N 403 
SER HB2  H N N 404 
SER HB3  H N N 405 
SER HG   H N N 406 
SER HXT  H N N 407 
THR N    N N N 408 
THR CA   C N S 409 
THR C    C N N 410 
THR O    O N N 411 
THR CB   C N R 412 
THR OG1  O N N 413 
THR CG2  C N N 414 
THR OXT  O N N 415 
THR H    H N N 416 
THR H2   H N N 417 
THR HA   H N N 418 
THR HB   H N N 419 
THR HG1  H N N 420 
THR HG21 H N N 421 
THR HG22 H N N 422 
THR HG23 H N N 423 
THR HXT  H N N 424 
TRP N    N N N 425 
TRP CA   C N S 426 
TRP C    C N N 427 
TRP O    O N N 428 
TRP CB   C N N 429 
TRP CG   C Y N 430 
TRP CD1  C Y N 431 
TRP CD2  C Y N 432 
TRP NE1  N Y N 433 
TRP CE2  C Y N 434 
TRP CE3  C Y N 435 
TRP CZ2  C Y N 436 
TRP CZ3  C Y N 437 
TRP CH2  C Y N 438 
TRP OXT  O N N 439 
TRP H    H N N 440 
TRP H2   H N N 441 
TRP HA   H N N 442 
TRP HB2  H N N 443 
TRP HB3  H N N 444 
TRP HD1  H N N 445 
TRP HE1  H N N 446 
TRP HE3  H N N 447 
TRP HZ2  H N N 448 
TRP HZ3  H N N 449 
TRP HH2  H N N 450 
TRP HXT  H N N 451 
TYR N    N N N 452 
TYR CA   C N S 453 
TYR C    C N N 454 
TYR O    O N N 455 
TYR CB   C N N 456 
TYR CG   C Y N 457 
TYR CD1  C Y N 458 
TYR CD2  C Y N 459 
TYR CE1  C Y N 460 
TYR CE2  C Y N 461 
TYR CZ   C Y N 462 
TYR OH   O N N 463 
TYR OXT  O N N 464 
TYR H    H N N 465 
TYR H2   H N N 466 
TYR HA   H N N 467 
TYR HB2  H N N 468 
TYR HB3  H N N 469 
TYR HD1  H N N 470 
TYR HD2  H N N 471 
TYR HE1  H N N 472 
TYR HE2  H N N 473 
TYR HH   H N N 474 
TYR HXT  H N N 475 
VAL N    N N N 476 
VAL CA   C N S 477 
VAL C    C N N 478 
VAL O    O N N 479 
VAL CB   C N N 480 
VAL CG1  C N N 481 
VAL CG2  C N N 482 
VAL OXT  O N N 483 
VAL H    H N N 484 
VAL H2   H N N 485 
VAL HA   H N N 486 
VAL HB   H N N 487 
VAL HG11 H N N 488 
VAL HG12 H N N 489 
VAL HG13 H N N 490 
VAL HG21 H N N 491 
VAL HG22 H N N 492 
VAL HG23 H N N 493 
VAL HXT  H N N 494 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ACY C   O    doub N N 1   
ACY C   OXT  sing N N 2   
ACY C   CH3  sing N N 3   
ACY OXT HXT  sing N N 4   
ACY CH3 H1   sing N N 5   
ACY CH3 H2   sing N N 6   
ACY CH3 H3   sing N N 7   
ALA N   CA   sing N N 8   
ALA N   H    sing N N 9   
ALA N   H2   sing N N 10  
ALA CA  C    sing N N 11  
ALA CA  CB   sing N N 12  
ALA CA  HA   sing N N 13  
ALA C   O    doub N N 14  
ALA C   OXT  sing N N 15  
ALA CB  HB1  sing N N 16  
ALA CB  HB2  sing N N 17  
ALA CB  HB3  sing N N 18  
ALA OXT HXT  sing N N 19  
ARG N   CA   sing N N 20  
ARG N   H    sing N N 21  
ARG N   H2   sing N N 22  
ARG CA  C    sing N N 23  
ARG CA  CB   sing N N 24  
ARG CA  HA   sing N N 25  
ARG C   O    doub N N 26  
ARG C   OXT  sing N N 27  
ARG CB  CG   sing N N 28  
ARG CB  HB2  sing N N 29  
ARG CB  HB3  sing N N 30  
ARG CG  CD   sing N N 31  
ARG CG  HG2  sing N N 32  
ARG CG  HG3  sing N N 33  
ARG CD  NE   sing N N 34  
ARG CD  HD2  sing N N 35  
ARG CD  HD3  sing N N 36  
ARG NE  CZ   sing N N 37  
ARG NE  HE   sing N N 38  
ARG CZ  NH1  sing N N 39  
ARG CZ  NH2  doub N N 40  
ARG NH1 HH11 sing N N 41  
ARG NH1 HH12 sing N N 42  
ARG NH2 HH21 sing N N 43  
ARG NH2 HH22 sing N N 44  
ARG OXT HXT  sing N N 45  
ASN N   CA   sing N N 46  
ASN N   H    sing N N 47  
ASN N   H2   sing N N 48  
ASN CA  C    sing N N 49  
ASN CA  CB   sing N N 50  
ASN CA  HA   sing N N 51  
ASN C   O    doub N N 52  
ASN C   OXT  sing N N 53  
ASN CB  CG   sing N N 54  
ASN CB  HB2  sing N N 55  
ASN CB  HB3  sing N N 56  
ASN CG  OD1  doub N N 57  
ASN CG  ND2  sing N N 58  
ASN ND2 HD21 sing N N 59  
ASN ND2 HD22 sing N N 60  
ASN OXT HXT  sing N N 61  
ASP N   CA   sing N N 62  
ASP N   H    sing N N 63  
ASP N   H2   sing N N 64  
ASP CA  C    sing N N 65  
ASP CA  CB   sing N N 66  
ASP CA  HA   sing N N 67  
ASP C   O    doub N N 68  
ASP C   OXT  sing N N 69  
ASP CB  CG   sing N N 70  
ASP CB  HB2  sing N N 71  
ASP CB  HB3  sing N N 72  
ASP CG  OD1  doub N N 73  
ASP CG  OD2  sing N N 74  
ASP OD2 HD2  sing N N 75  
ASP OXT HXT  sing N N 76  
COA N1A C2A  sing Y N 77  
COA N1A C6A  doub Y N 78  
COA C2A N3A  doub Y N 79  
COA C2A H2A  sing N N 80  
COA N3A C4A  sing Y N 81  
COA C4A C5A  doub Y N 82  
COA C4A N9A  sing Y N 83  
COA C5A C6A  sing Y N 84  
COA C5A N7A  sing Y N 85  
COA C6A N6A  sing N N 86  
COA N6A H61A sing N N 87  
COA N6A H62A sing N N 88  
COA N7A C8A  doub Y N 89  
COA C8A N9A  sing Y N 90  
COA C8A H8A  sing N N 91  
COA N9A C1B  sing N N 92  
COA C1B C2B  sing N N 93  
COA C1B O4B  sing N N 94  
COA C1B H1B  sing N N 95  
COA C2B O2B  sing N N 96  
COA C2B C3B  sing N N 97  
COA C2B H2B  sing N N 98  
COA O2B HO2A sing N N 99  
COA C3B O3B  sing N N 100 
COA C3B C4B  sing N N 101 
COA C3B H3B  sing N N 102 
COA O3B P3B  sing N N 103 
COA P3B O7A  doub N N 104 
COA P3B O8A  sing N N 105 
COA P3B O9A  sing N N 106 
COA O8A HOA8 sing N N 107 
COA O9A HOA9 sing N N 108 
COA C4B O4B  sing N N 109 
COA C4B C5B  sing N N 110 
COA C4B H4B  sing N N 111 
COA C5B O5B  sing N N 112 
COA C5B H51A sing N N 113 
COA C5B H52A sing N N 114 
COA O5B P1A  sing N N 115 
COA P1A O1A  doub N N 116 
COA P1A O2A  sing N N 117 
COA P1A O3A  sing N N 118 
COA O2A HOA2 sing N N 119 
COA O3A P2A  sing N N 120 
COA P2A O4A  doub N N 121 
COA P2A O5A  sing N N 122 
COA P2A O6A  sing N N 123 
COA O5A HOA5 sing N N 124 
COA O6A CCP  sing N N 125 
COA CBP CCP  sing N N 126 
COA CBP CDP  sing N N 127 
COA CBP CEP  sing N N 128 
COA CBP CAP  sing N N 129 
COA CCP H121 sing N N 130 
COA CCP H122 sing N N 131 
COA CDP H131 sing N N 132 
COA CDP H132 sing N N 133 
COA CDP H133 sing N N 134 
COA CEP H141 sing N N 135 
COA CEP H142 sing N N 136 
COA CEP H143 sing N N 137 
COA CAP OAP  sing N N 138 
COA CAP C9P  sing N N 139 
COA CAP H10  sing N N 140 
COA OAP HO1  sing N N 141 
COA C9P O9P  doub N N 142 
COA C9P N8P  sing N N 143 
COA N8P C7P  sing N N 144 
COA N8P HN8  sing N N 145 
COA C7P C6P  sing N N 146 
COA C7P H71  sing N N 147 
COA C7P H72  sing N N 148 
COA C6P C5P  sing N N 149 
COA C6P H61  sing N N 150 
COA C6P H62  sing N N 151 
COA C5P O5P  doub N N 152 
COA C5P N4P  sing N N 153 
COA N4P C3P  sing N N 154 
COA N4P HN4  sing N N 155 
COA C3P C2P  sing N N 156 
COA C3P H31  sing N N 157 
COA C3P H32  sing N N 158 
COA C2P S1P  sing N N 159 
COA C2P H21  sing N N 160 
COA C2P H22  sing N N 161 
COA S1P HS1  sing N N 162 
CYS N   CA   sing N N 163 
CYS N   H    sing N N 164 
CYS N   H2   sing N N 165 
CYS CA  C    sing N N 166 
CYS CA  CB   sing N N 167 
CYS CA  HA   sing N N 168 
CYS C   O    doub N N 169 
CYS C   OXT  sing N N 170 
CYS CB  SG   sing N N 171 
CYS CB  HB2  sing N N 172 
CYS CB  HB3  sing N N 173 
CYS SG  HG   sing N N 174 
CYS OXT HXT  sing N N 175 
GLN N   CA   sing N N 176 
GLN N   H    sing N N 177 
GLN N   H2   sing N N 178 
GLN CA  C    sing N N 179 
GLN CA  CB   sing N N 180 
GLN CA  HA   sing N N 181 
GLN C   O    doub N N 182 
GLN C   OXT  sing N N 183 
GLN CB  CG   sing N N 184 
GLN CB  HB2  sing N N 185 
GLN CB  HB3  sing N N 186 
GLN CG  CD   sing N N 187 
GLN CG  HG2  sing N N 188 
GLN CG  HG3  sing N N 189 
GLN CD  OE1  doub N N 190 
GLN CD  NE2  sing N N 191 
GLN NE2 HE21 sing N N 192 
GLN NE2 HE22 sing N N 193 
GLN OXT HXT  sing N N 194 
GLU N   CA   sing N N 195 
GLU N   H    sing N N 196 
GLU N   H2   sing N N 197 
GLU CA  C    sing N N 198 
GLU CA  CB   sing N N 199 
GLU CA  HA   sing N N 200 
GLU C   O    doub N N 201 
GLU C   OXT  sing N N 202 
GLU CB  CG   sing N N 203 
GLU CB  HB2  sing N N 204 
GLU CB  HB3  sing N N 205 
GLU CG  CD   sing N N 206 
GLU CG  HG2  sing N N 207 
GLU CG  HG3  sing N N 208 
GLU CD  OE1  doub N N 209 
GLU CD  OE2  sing N N 210 
GLU OE2 HE2  sing N N 211 
GLU OXT HXT  sing N N 212 
GLY N   CA   sing N N 213 
GLY N   H    sing N N 214 
GLY N   H2   sing N N 215 
GLY CA  C    sing N N 216 
GLY CA  HA2  sing N N 217 
GLY CA  HA3  sing N N 218 
GLY C   O    doub N N 219 
GLY C   OXT  sing N N 220 
GLY OXT HXT  sing N N 221 
HIS N   CA   sing N N 222 
HIS N   H    sing N N 223 
HIS N   H2   sing N N 224 
HIS CA  C    sing N N 225 
HIS CA  CB   sing N N 226 
HIS CA  HA   sing N N 227 
HIS C   O    doub N N 228 
HIS C   OXT  sing N N 229 
HIS CB  CG   sing N N 230 
HIS CB  HB2  sing N N 231 
HIS CB  HB3  sing N N 232 
HIS CG  ND1  sing Y N 233 
HIS CG  CD2  doub Y N 234 
HIS ND1 CE1  doub Y N 235 
HIS ND1 HD1  sing N N 236 
HIS CD2 NE2  sing Y N 237 
HIS CD2 HD2  sing N N 238 
HIS CE1 NE2  sing Y N 239 
HIS CE1 HE1  sing N N 240 
HIS NE2 HE2  sing N N 241 
HIS OXT HXT  sing N N 242 
HOH O   H1   sing N N 243 
HOH O   H2   sing N N 244 
ILE N   CA   sing N N 245 
ILE N   H    sing N N 246 
ILE N   H2   sing N N 247 
ILE CA  C    sing N N 248 
ILE CA  CB   sing N N 249 
ILE CA  HA   sing N N 250 
ILE C   O    doub N N 251 
ILE C   OXT  sing N N 252 
ILE CB  CG1  sing N N 253 
ILE CB  CG2  sing N N 254 
ILE CB  HB   sing N N 255 
ILE CG1 CD1  sing N N 256 
ILE CG1 HG12 sing N N 257 
ILE CG1 HG13 sing N N 258 
ILE CG2 HG21 sing N N 259 
ILE CG2 HG22 sing N N 260 
ILE CG2 HG23 sing N N 261 
ILE CD1 HD11 sing N N 262 
ILE CD1 HD12 sing N N 263 
ILE CD1 HD13 sing N N 264 
ILE OXT HXT  sing N N 265 
LEU N   CA   sing N N 266 
LEU N   H    sing N N 267 
LEU N   H2   sing N N 268 
LEU CA  C    sing N N 269 
LEU CA  CB   sing N N 270 
LEU CA  HA   sing N N 271 
LEU C   O    doub N N 272 
LEU C   OXT  sing N N 273 
LEU CB  CG   sing N N 274 
LEU CB  HB2  sing N N 275 
LEU CB  HB3  sing N N 276 
LEU CG  CD1  sing N N 277 
LEU CG  CD2  sing N N 278 
LEU CG  HG   sing N N 279 
LEU CD1 HD11 sing N N 280 
LEU CD1 HD12 sing N N 281 
LEU CD1 HD13 sing N N 282 
LEU CD2 HD21 sing N N 283 
LEU CD2 HD22 sing N N 284 
LEU CD2 HD23 sing N N 285 
LEU OXT HXT  sing N N 286 
LYS N   CA   sing N N 287 
LYS N   H    sing N N 288 
LYS N   H2   sing N N 289 
LYS CA  C    sing N N 290 
LYS CA  CB   sing N N 291 
LYS CA  HA   sing N N 292 
LYS C   O    doub N N 293 
LYS C   OXT  sing N N 294 
LYS CB  CG   sing N N 295 
LYS CB  HB2  sing N N 296 
LYS CB  HB3  sing N N 297 
LYS CG  CD   sing N N 298 
LYS CG  HG2  sing N N 299 
LYS CG  HG3  sing N N 300 
LYS CD  CE   sing N N 301 
LYS CD  HD2  sing N N 302 
LYS CD  HD3  sing N N 303 
LYS CE  NZ   sing N N 304 
LYS CE  HE2  sing N N 305 
LYS CE  HE3  sing N N 306 
LYS NZ  HZ1  sing N N 307 
LYS NZ  HZ2  sing N N 308 
LYS NZ  HZ3  sing N N 309 
LYS OXT HXT  sing N N 310 
MET N   CA   sing N N 311 
MET N   H    sing N N 312 
MET N   H2   sing N N 313 
MET CA  C    sing N N 314 
MET CA  CB   sing N N 315 
MET CA  HA   sing N N 316 
MET C   O    doub N N 317 
MET C   OXT  sing N N 318 
MET CB  CG   sing N N 319 
MET CB  HB2  sing N N 320 
MET CB  HB3  sing N N 321 
MET CG  SD   sing N N 322 
MET CG  HG2  sing N N 323 
MET CG  HG3  sing N N 324 
MET SD  CE   sing N N 325 
MET CE  HE1  sing N N 326 
MET CE  HE2  sing N N 327 
MET CE  HE3  sing N N 328 
MET OXT HXT  sing N N 329 
OAA O1  C1   doub N N 330 
OAA O2  C1   sing N N 331 
OAA O4  C4   doub N N 332 
OAA O5  C4   sing N N 333 
OAA O5  HO5  sing N N 334 
OAA O3  C3   doub N N 335 
OAA C1  C2   sing N N 336 
OAA C2  C3   sing N N 337 
OAA C2  H21  sing N N 338 
OAA C2  H22  sing N N 339 
OAA C3  C4   sing N N 340 
PHE N   CA   sing N N 341 
PHE N   H    sing N N 342 
PHE N   H2   sing N N 343 
PHE CA  C    sing N N 344 
PHE CA  CB   sing N N 345 
PHE CA  HA   sing N N 346 
PHE C   O    doub N N 347 
PHE C   OXT  sing N N 348 
PHE CB  CG   sing N N 349 
PHE CB  HB2  sing N N 350 
PHE CB  HB3  sing N N 351 
PHE CG  CD1  doub Y N 352 
PHE CG  CD2  sing Y N 353 
PHE CD1 CE1  sing Y N 354 
PHE CD1 HD1  sing N N 355 
PHE CD2 CE2  doub Y N 356 
PHE CD2 HD2  sing N N 357 
PHE CE1 CZ   doub Y N 358 
PHE CE1 HE1  sing N N 359 
PHE CE2 CZ   sing Y N 360 
PHE CE2 HE2  sing N N 361 
PHE CZ  HZ   sing N N 362 
PHE OXT HXT  sing N N 363 
PRO N   CA   sing N N 364 
PRO N   CD   sing N N 365 
PRO N   H    sing N N 366 
PRO CA  C    sing N N 367 
PRO CA  CB   sing N N 368 
PRO CA  HA   sing N N 369 
PRO C   O    doub N N 370 
PRO C   OXT  sing N N 371 
PRO CB  CG   sing N N 372 
PRO CB  HB2  sing N N 373 
PRO CB  HB3  sing N N 374 
PRO CG  CD   sing N N 375 
PRO CG  HG2  sing N N 376 
PRO CG  HG3  sing N N 377 
PRO CD  HD2  sing N N 378 
PRO CD  HD3  sing N N 379 
PRO OXT HXT  sing N N 380 
SER N   CA   sing N N 381 
SER N   H    sing N N 382 
SER N   H2   sing N N 383 
SER CA  C    sing N N 384 
SER CA  CB   sing N N 385 
SER CA  HA   sing N N 386 
SER C   O    doub N N 387 
SER C   OXT  sing N N 388 
SER CB  OG   sing N N 389 
SER CB  HB2  sing N N 390 
SER CB  HB3  sing N N 391 
SER OG  HG   sing N N 392 
SER OXT HXT  sing N N 393 
THR N   CA   sing N N 394 
THR N   H    sing N N 395 
THR N   H2   sing N N 396 
THR CA  C    sing N N 397 
THR CA  CB   sing N N 398 
THR CA  HA   sing N N 399 
THR C   O    doub N N 400 
THR C   OXT  sing N N 401 
THR CB  OG1  sing N N 402 
THR CB  CG2  sing N N 403 
THR CB  HB   sing N N 404 
THR OG1 HG1  sing N N 405 
THR CG2 HG21 sing N N 406 
THR CG2 HG22 sing N N 407 
THR CG2 HG23 sing N N 408 
THR OXT HXT  sing N N 409 
TRP N   CA   sing N N 410 
TRP N   H    sing N N 411 
TRP N   H2   sing N N 412 
TRP CA  C    sing N N 413 
TRP CA  CB   sing N N 414 
TRP CA  HA   sing N N 415 
TRP C   O    doub N N 416 
TRP C   OXT  sing N N 417 
TRP CB  CG   sing N N 418 
TRP CB  HB2  sing N N 419 
TRP CB  HB3  sing N N 420 
TRP CG  CD1  doub Y N 421 
TRP CG  CD2  sing Y N 422 
TRP CD1 NE1  sing Y N 423 
TRP CD1 HD1  sing N N 424 
TRP CD2 CE2  doub Y N 425 
TRP CD2 CE3  sing Y N 426 
TRP NE1 CE2  sing Y N 427 
TRP NE1 HE1  sing N N 428 
TRP CE2 CZ2  sing Y N 429 
TRP CE3 CZ3  doub Y N 430 
TRP CE3 HE3  sing N N 431 
TRP CZ2 CH2  doub Y N 432 
TRP CZ2 HZ2  sing N N 433 
TRP CZ3 CH2  sing Y N 434 
TRP CZ3 HZ3  sing N N 435 
TRP CH2 HH2  sing N N 436 
TRP OXT HXT  sing N N 437 
TYR N   CA   sing N N 438 
TYR N   H    sing N N 439 
TYR N   H2   sing N N 440 
TYR CA  C    sing N N 441 
TYR CA  CB   sing N N 442 
TYR CA  HA   sing N N 443 
TYR C   O    doub N N 444 
TYR C   OXT  sing N N 445 
TYR CB  CG   sing N N 446 
TYR CB  HB2  sing N N 447 
TYR CB  HB3  sing N N 448 
TYR CG  CD1  doub Y N 449 
TYR CG  CD2  sing Y N 450 
TYR CD1 CE1  sing Y N 451 
TYR CD1 HD1  sing N N 452 
TYR CD2 CE2  doub Y N 453 
TYR CD2 HD2  sing N N 454 
TYR CE1 CZ   doub Y N 455 
TYR CE1 HE1  sing N N 456 
TYR CE2 CZ   sing Y N 457 
TYR CE2 HE2  sing N N 458 
TYR CZ  OH   sing N N 459 
TYR OH  HH   sing N N 460 
TYR OXT HXT  sing N N 461 
VAL N   CA   sing N N 462 
VAL N   H    sing N N 463 
VAL N   H2   sing N N 464 
VAL CA  C    sing N N 465 
VAL CA  CB   sing N N 466 
VAL CA  HA   sing N N 467 
VAL C   O    doub N N 468 
VAL C   OXT  sing N N 469 
VAL CB  CG1  sing N N 470 
VAL CB  CG2  sing N N 471 
VAL CB  HB   sing N N 472 
VAL CG1 HG11 sing N N 473 
VAL CG1 HG12 sing N N 474 
VAL CG1 HG13 sing N N 475 
VAL CG2 HG21 sing N N 476 
VAL CG2 HG22 sing N N 477 
VAL CG2 HG23 sing N N 478 
VAL OXT HXT  sing N N 479 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5UZR 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8ZVT 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017289 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.017289 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.003994 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 3   ? 3.726  -8.860  -13.845 1.00 66.50 ? 30  SER A N   1 
ATOM   2    C CA  . SER A 1 3   ? 3.853  -7.990  -15.047 1.00 69.13 ? 30  SER A CA  1 
ATOM   3    C C   . SER A 1 3   ? 5.025  -8.498  -15.893 1.00 72.53 ? 30  SER A C   1 
ATOM   4    O O   . SER A 1 3   ? 4.864  -9.452  -16.656 1.00 71.11 ? 30  SER A O   1 
ATOM   5    C CB  . SER A 1 3   ? 3.972  -6.525  -14.636 1.00 71.22 ? 30  SER A CB  1 
ATOM   6    O OG  . SER A 1 3   ? 4.170  -5.665  -15.750 1.00 72.05 ? 30  SER A OG  1 
ATOM   7    N N   . THR A 1 4   ? 6.205  -7.880  -15.740 1.00 67.93 ? 31  THR A N   1 
ATOM   8    C CA  . THR A 1 4   ? 7.458  -8.546  -16.057 1.00 64.92 ? 31  THR A CA  1 
ATOM   9    C C   . THR A 1 4   ? 8.226  -8.865  -14.774 1.00 62.48 ? 31  THR A C   1 
ATOM   10   O O   . THR A 1 4   ? 9.330  -9.402  -14.874 1.00 67.10 ? 31  THR A O   1 
ATOM   11   C CB  . THR A 1 4   ? 8.327  -7.701  -16.989 1.00 59.08 ? 31  THR A CB  1 
ATOM   12   O OG1 . THR A 1 4   ? 8.459  -6.470  -16.286 1.00 60.84 ? 31  THR A OG1 1 
ATOM   13   C CG2 . THR A 1 4   ? 7.724  -7.541  -18.372 1.00 56.35 ? 31  THR A CG2 1 
ATOM   14   N N   . ASN A 1 5   ? 7.675  -8.550  -13.585 1.00 49.59 ? 32  ASN A N   1 
ATOM   15   C CA  . ASN A 1 5   ? 8.397  -8.841  -12.352 1.00 41.74 ? 32  ASN A CA  1 
ATOM   16   C C   . ASN A 1 5   ? 8.135  -10.290 -11.938 1.00 33.03 ? 32  ASN A C   1 
ATOM   17   O O   . ASN A 1 5   ? 7.030  -10.668 -11.553 1.00 29.23 ? 32  ASN A O   1 
ATOM   18   C CB  . ASN A 1 5   ? 8.105  -7.878  -11.211 1.00 42.94 ? 32  ASN A CB  1 
ATOM   19   C CG  . ASN A 1 5   ? 9.016  -8.182  -10.042 1.00 51.55 ? 32  ASN A CG  1 
ATOM   20   O OD1 . ASN A 1 5   ? 9.118  -9.339  -9.617  1.00 55.94 ? 32  ASN A OD1 1 
ATOM   21   N ND2 . ASN A 1 5   ? 9.737  -7.192  -9.543  1.00 52.89 ? 32  ASN A ND2 1 
ATOM   22   N N   . LEU A 1 6   ? 9.182  -11.107 -12.042 1.00 28.89 ? 33  LEU A N   1 
ATOM   23   C CA  . LEU A 1 6   ? 9.085  -12.526 -11.764 1.00 28.42 ? 33  LEU A CA  1 
ATOM   24   C C   . LEU A 1 6   ? 8.610  -12.765 -10.331 1.00 25.13 ? 33  LEU A C   1 
ATOM   25   O O   . LEU A 1 6   ? 7.814  -13.650 -10.062 1.00 25.73 ? 33  LEU A O   1 
ATOM   26   C CB  . LEU A 1 6   ? 10.483 -13.082 -12.014 1.00 27.22 ? 33  LEU A CB  1 
ATOM   27   C CG  . LEU A 1 6   ? 10.673 -14.579 -11.798 1.00 27.34 ? 33  LEU A CG  1 
ATOM   28   C CD1 . LEU A 1 6   ? 9.651  -15.402 -12.550 1.00 29.34 ? 33  LEU A CD1 1 
ATOM   29   C CD2 . LEU A 1 6   ? 12.070 -14.911 -12.272 1.00 29.77 ? 33  LEU A CD2 1 
ATOM   30   N N   . LYS A 1 7   ? 9.132  -11.991 -9.388  1.00 26.01 ? 34  LYS A N   1 
ATOM   31   C CA  . LYS A 1 7   ? 8.804  -12.215 -7.993  1.00 29.88 ? 34  LYS A CA  1 
ATOM   32   C C   . LYS A 1 7   ? 7.297  -12.093 -7.747  1.00 31.76 ? 34  LYS A C   1 
ATOM   33   O O   . LYS A 1 7   ? 6.766  -12.833 -6.925  1.00 31.11 ? 34  LYS A O   1 
ATOM   34   C CB  . LYS A 1 7   ? 9.576  -11.257 -7.088  1.00 30.48 ? 34  LYS A CB  1 
ATOM   35   C CG  . LYS A 1 7   ? 9.607  -11.729 -5.643  1.00 31.25 ? 34  LYS A CG  1 
ATOM   36   C CD  . LYS A 1 7   ? 10.187 -10.635 -4.755  1.00 30.56 ? 34  LYS A CD  1 
ATOM   37   C CE  . LYS A 1 7   ? 10.576 -11.090 -3.389  1.00 30.36 ? 34  LYS A CE  1 
ATOM   38   N NZ  . LYS A 1 7   ? 11.551 -10.168 -2.806  1.00 30.73 ? 34  LYS A NZ  1 
ATOM   39   N N   . ASP A 1 8   ? 6.626  -11.164 -8.444  1.00 32.22 ? 35  ASP A N   1 
ATOM   40   C CA  . ASP A 1 8   ? 5.188  -10.965 -8.287  1.00 35.62 ? 35  ASP A CA  1 
ATOM   41   C C   . ASP A 1 8   ? 4.401  -12.118 -8.912  1.00 29.62 ? 35  ASP A C   1 
ATOM   42   O O   . ASP A 1 8   ? 3.384  -12.548 -8.384  1.00 28.58 ? 35  ASP A O   1 
ATOM   43   C CB  . ASP A 1 8   ? 4.731  -9.657  -8.918  1.00 37.27 ? 35  ASP A CB  1 
ATOM   44   C CG  . ASP A 1 8   ? 5.223  -8.413  -8.203  1.00 40.50 ? 35  ASP A CG  1 
ATOM   45   O OD1 . ASP A 1 8   ? 4.936  -8.301  -6.999  1.00 51.63 ? 35  ASP A OD1 1 
ATOM   46   O OD2 . ASP A 1 8   ? 5.906  -7.585  -8.846  1.00 48.95 ? 35  ASP A OD2 1 
ATOM   47   N N   . ILE A 1 9   ? 4.855  -12.567 -10.078 1.00 29.58 ? 36  ILE A N   1 
ATOM   48   C CA  . ILE A 1 9   ? 4.228  -13.674 -10.769 1.00 30.37 ? 36  ILE A CA  1 
ATOM   49   C C   . ILE A 1 9   ? 4.373  -14.916 -9.914  1.00 31.59 ? 36  ILE A C   1 
ATOM   50   O O   . ILE A 1 9   ? 3.425  -15.677 -9.784  1.00 34.15 ? 36  ILE A O   1 
ATOM   51   C CB  . ILE A 1 9   ? 4.852  -13.846 -12.164 1.00 34.09 ? 36  ILE A CB  1 
ATOM   52   C CG1 . ILE A 1 9   ? 4.438  -12.681 -13.082 1.00 38.25 ? 36  ILE A CG1 1 
ATOM   53   C CG2 . ILE A 1 9   ? 4.491  -15.201 -12.769 1.00 34.23 ? 36  ILE A CG2 1 
ATOM   54   C CD1 . ILE A 1 9   ? 5.449  -12.344 -14.163 1.00 42.11 ? 36  ILE A CD1 1 
ATOM   55   N N   . LEU A 1 10  ? 5.564  -15.108 -9.324  1.00 28.88 ? 37  LEU A N   1 
ATOM   56   C CA  . LEU A 1 10  ? 5.799  -16.259 -8.461  1.00 29.62 ? 37  LEU A CA  1 
ATOM   57   C C   . LEU A 1 10  ? 4.983  -16.168 -7.168  1.00 29.66 ? 37  LEU A C   1 
ATOM   58   O O   . LEU A 1 10  ? 4.473  -17.184 -6.692  1.00 28.66 ? 37  LEU A O   1 
ATOM   59   C CB  . LEU A 1 10  ? 7.302  -16.272 -8.208  1.00 33.64 ? 37  LEU A CB  1 
ATOM   60   C CG  . LEU A 1 10  ? 7.864  -17.398 -7.352  1.00 34.26 ? 37  LEU A CG  1 
ATOM   61   C CD1 . LEU A 1 10  ? 7.554  -18.770 -7.913  1.00 32.75 ? 37  LEU A CD1 1 
ATOM   62   C CD2 . LEU A 1 10  ? 9.375  -17.150 -7.278  1.00 35.31 ? 37  LEU A CD2 1 
ATOM   63   N N   . ALA A 1 11  ? 4.817  -14.949 -6.620  1.00 26.23 ? 38  ALA A N   1 
ATOM   64   C CA  . ALA A 1 11  ? 3.946  -14.750 -5.476  1.00 26.37 ? 38  ALA A CA  1 
ATOM   65   C C   . ALA A 1 11  ? 2.521  -15.243 -5.767  1.00 29.43 ? 38  ALA A C   1 
ATOM   66   O O   . ALA A 1 11  ? 1.859  -15.725 -4.863  1.00 31.73 ? 38  ALA A O   1 
ATOM   67   C CB  . ALA A 1 11  ? 3.936  -13.289 -5.054  1.00 25.44 ? 38  ALA A CB  1 
ATOM   68   N N   . ASP A 1 12  ? 2.030  -15.100 -7.007  1.00 36.84 ? 39  ASP A N   1 
ATOM   69   C CA  . ASP A 1 12  ? 0.672  -15.522 -7.362  1.00 37.35 ? 39  ASP A CA  1 
ATOM   70   C C   . ASP A 1 12  ? 0.548  -17.034 -7.533  1.00 34.05 ? 39  ASP A C   1 
ATOM   71   O O   . ASP A 1 12  ? -0.518 -17.599 -7.291  1.00 33.70 ? 39  ASP A O   1 
ATOM   72   C CB  . ASP A 1 12  ? 0.213  -14.939 -8.686  1.00 46.79 ? 39  ASP A CB  1 
ATOM   73   C CG  . ASP A 1 12  ? -0.777 -13.792 -8.571  1.00 62.56 ? 39  ASP A CG  1 
ATOM   74   O OD1 . ASP A 1 12  ? -0.372 -12.738 -8.019  1.00 64.96 ? 39  ASP A OD1 1 
ATOM   75   O OD2 . ASP A 1 12  ? -1.948 -13.981 -9.011  1.00 64.57 ? 39  ASP A OD2 1 
ATOM   76   N N   . LEU A 1 13  ? 1.624  -17.673 -8.013  1.00 32.89 ? 40  LEU A N   1 
ATOM   77   C CA  . LEU A 1 13  ? 1.616  -19.100 -8.323  1.00 30.07 ? 40  LEU A CA  1 
ATOM   78   C C   . LEU A 1 13  ? 1.628  -19.932 -7.045  1.00 29.15 ? 40  LEU A C   1 
ATOM   79   O O   . LEU A 1 13  ? 1.031  -20.999 -7.018  1.00 30.61 ? 40  LEU A O   1 
ATOM   80   C CB  . LEU A 1 13  ? 2.797  -19.470 -9.223  1.00 27.56 ? 40  LEU A CB  1 
ATOM   81   C CG  . LEU A 1 13  ? 2.767  -18.859 -10.632 1.00 29.05 ? 40  LEU A CG  1 
ATOM   82   C CD1 . LEU A 1 13  ? 4.090  -19.003 -11.356 1.00 28.64 ? 40  LEU A CD1 1 
ATOM   83   C CD2 . LEU A 1 13  ? 1.641  -19.494 -11.442 1.00 28.36 ? 40  LEU A CD2 1 
ATOM   84   N N   . ILE A 1 14  ? 2.323  -19.455 -6.009  1.00 27.11 ? 41  ILE A N   1 
ATOM   85   C CA  . ILE A 1 14  ? 2.681  -20.295 -4.874  1.00 28.71 ? 41  ILE A CA  1 
ATOM   86   C C   . ILE A 1 14  ? 1.451  -20.790 -4.116  1.00 26.12 ? 41  ILE A C   1 
ATOM   87   O O   . ILE A 1 14  ? 1.399  -21.961 -3.775  1.00 24.40 ? 41  ILE A O   1 
ATOM   88   C CB  . ILE A 1 14  ? 3.659  -19.557 -3.950  1.00 27.16 ? 41  ILE A CB  1 
ATOM   89   C CG1 . ILE A 1 14  ? 5.057  -19.522 -4.563  1.00 26.41 ? 41  ILE A CG1 1 
ATOM   90   C CG2 . ILE A 1 14  ? 3.659  -20.160 -2.549  1.00 26.80 ? 41  ILE A CG2 1 
ATOM   91   C CD1 . ILE A 1 14  ? 5.980  -18.519 -3.909  1.00 27.75 ? 41  ILE A CD1 1 
ATOM   92   N N   . PRO A 1 15  ? 0.476  -19.926 -3.764  1.00 27.29 ? 42  PRO A N   1 
ATOM   93   C CA  . PRO A 1 15  ? -0.687 -20.354 -2.996  1.00 26.64 ? 42  PRO A CA  1 
ATOM   94   C C   . PRO A 1 15  ? -1.433 -21.508 -3.647  1.00 25.22 ? 42  PRO A C   1 
ATOM   95   O O   . PRO A 1 15  ? -1.914 -22.391 -2.952  1.00 31.69 ? 42  PRO A O   1 
ATOM   96   C CB  . PRO A 1 15  ? -1.547 -19.090 -2.955  1.00 27.55 ? 42  PRO A CB  1 
ATOM   97   C CG  . PRO A 1 15  ? -0.559 -17.959 -3.099  1.00 28.04 ? 42  PRO A CG  1 
ATOM   98   C CD  . PRO A 1 15  ? 0.430  -18.486 -4.083  1.00 29.37 ? 42  PRO A CD  1 
ATOM   99   N N   . LYS A 1 16  ? -1.486 -21.487 -4.970  1.00 26.52 ? 43  LYS A N   1 
ATOM   100  C CA  . LYS A 1 16  ? -2.229 -22.453 -5.763  1.00 29.34 ? 43  LYS A CA  1 
ATOM   101  C C   . LYS A 1 16  ? -1.556 -23.805 -5.618  1.00 27.77 ? 43  LYS A C   1 
ATOM   102  O O   . LYS A 1 16  ? -2.213 -24.835 -5.446  1.00 25.15 ? 43  LYS A O   1 
ATOM   103  C CB  . LYS A 1 16  ? -2.175 -21.997 -7.222  1.00 34.68 ? 43  LYS A CB  1 
ATOM   104  C CG  . LYS A 1 16  ? -2.079 -20.467 -7.420  1.00 48.32 ? 43  LYS A CG  1 
ATOM   105  C CD  . LYS A 1 16  ? -3.281 -19.747 -8.023  1.00 52.49 ? 43  LYS A CD  1 
ATOM   106  C CE  . LYS A 1 16  ? -3.171 -19.612 -9.524  1.00 51.20 ? 43  LYS A CE  1 
ATOM   107  N NZ  . LYS A 1 16  ? -4.136 -18.609 -9.975  1.00 54.63 ? 43  LYS A NZ  1 
ATOM   108  N N   . GLU A 1 17  ? -0.217 -23.780 -5.694  1.00 26.19 ? 44  GLU A N   1 
ATOM   109  C CA  . GLU A 1 17  ? 0.556  -25.006 -5.568  1.00 26.49 ? 44  GLU A CA  1 
ATOM   110  C C   . GLU A 1 17  ? 0.492  -25.524 -4.136  1.00 23.14 ? 44  GLU A C   1 
ATOM   111  O O   . GLU A 1 17  ? 0.468  -26.739 -3.948  1.00 27.13 ? 44  GLU A O   1 
ATOM   112  C CB  . GLU A 1 17  ? 2.004  -24.907 -6.059  1.00 28.15 ? 44  GLU A CB  1 
ATOM   113  C CG  . GLU A 1 17  ? 2.095  -24.784 -7.578  1.00 29.79 ? 44  GLU A CG  1 
ATOM   114  C CD  . GLU A 1 17  ? 1.337  -25.879 -8.314  1.00 32.26 ? 44  GLU A CD  1 
ATOM   115  O OE1 . GLU A 1 17  ? 1.596  -27.086 -8.058  1.00 38.16 ? 44  GLU A OE1 1 
ATOM   116  O OE2 . GLU A 1 17  ? 0.440  -25.518 -9.102  1.00 38.00 ? 44  GLU A OE2 1 
ATOM   117  N N   . GLN A 1 18  ? 0.458  -24.638 -3.137  1.00 24.02 ? 45  GLN A N   1 
ATOM   118  C CA  . GLN A 1 18  ? 0.341  -25.093 -1.761  1.00 23.12 ? 45  GLN A CA  1 
ATOM   119  C C   . GLN A 1 18  ? -0.997 -25.807 -1.585  1.00 22.45 ? 45  GLN A C   1 
ATOM   120  O O   . GLN A 1 18  ? -1.056 -26.834 -0.923  1.00 21.94 ? 45  GLN A O   1 
ATOM   121  C CB  . GLN A 1 18  ? 0.456  -23.975 -0.730  1.00 26.83 ? 45  GLN A CB  1 
ATOM   122  C CG  . GLN A 1 18  ? 1.822  -23.308 -0.705  1.00 27.60 ? 45  GLN A CG  1 
ATOM   123  C CD  . GLN A 1 18  ? 1.828  -22.027 0.085   1.00 29.52 ? 45  GLN A CD  1 
ATOM   124  O OE1 . GLN A 1 18  ? 0.858  -21.261 0.086   1.00 29.96 ? 45  GLN A OE1 1 
ATOM   125  N NE2 . GLN A 1 18  ? 2.935  -21.784 0.761   1.00 28.43 ? 45  GLN A NE2 1 
ATOM   126  N N   . ALA A 1 19  ? -2.067 -25.263 -2.173  1.00 22.19 ? 46  ALA A N   1 
ATOM   127  C CA  . ALA A 1 19  ? -3.393 -25.836 -1.981  1.00 22.31 ? 46  ALA A CA  1 
ATOM   128  C C   . ALA A 1 19  ? -3.471 -27.225 -2.611  1.00 23.72 ? 46  ALA A C   1 
ATOM   129  O O   . ALA A 1 19  ? -4.032 -28.150 -2.037  1.00 22.98 ? 46  ALA A O   1 
ATOM   130  C CB  . ALA A 1 19  ? -4.429 -24.911 -2.555  1.00 23.35 ? 46  ALA A CB  1 
ATOM   131  N N   . ARG A 1 20  ? -2.895 -27.340 -3.814  1.00 26.50 ? 47  ARG A N   1 
ATOM   132  C CA  . ARG A 1 20  ? -2.912 -28.550 -4.617  1.00 29.06 ? 47  ARG A CA  1 
ATOM   133  C C   . ARG A 1 20  ? -2.201 -29.660 -3.863  1.00 26.51 ? 47  ARG A C   1 
ATOM   134  O O   . ARG A 1 20  ? -2.720 -30.755 -3.705  1.00 28.18 ? 47  ARG A O   1 
ATOM   135  C CB  . ARG A 1 20  ? -2.292 -28.112 -5.951  1.00 33.67 ? 47  ARG A CB  1 
ATOM   136  C CG  . ARG A 1 20  ? -1.902 -29.180 -6.959  1.00 43.15 ? 47  ARG A CG  1 
ATOM   137  C CD  . ARG A 1 20  ? -1.807 -28.512 -8.344  1.00 49.39 ? 47  ARG A CD  1 
ATOM   138  N NE  . ARG A 1 20  ? -0.866 -29.199 -9.228  1.00 57.61 ? 47  ARG A NE  1 
ATOM   139  C CZ  . ARG A 1 20  ? -1.188 -30.073 -10.178 1.00 71.09 ? 47  ARG A CZ  1 
ATOM   140  N NH1 . ARG A 1 20  ? -0.248 -30.533 -10.998 1.00 65.99 ? 47  ARG A NH1 1 
ATOM   141  N NH2 . ARG A 1 20  ? -2.446 -30.471 -10.308 1.00 75.71 ? 47  ARG A NH2 1 
ATOM   142  N N   . ILE A 1 21  ? -1.044 -29.327 -3.300  1.00 25.20 ? 48  ILE A N   1 
ATOM   143  C CA  . ILE A 1 21  ? -0.268 -30.295 -2.551  1.00 26.53 ? 48  ILE A CA  1 
ATOM   144  C C   . ILE A 1 21  ? -0.966 -30.677 -1.247  1.00 24.03 ? 48  ILE A C   1 
ATOM   145  O O   . ILE A 1 21  ? -0.933 -31.843 -0.858  1.00 25.53 ? 48  ILE A O   1 
ATOM   146  C CB  . ILE A 1 21  ? 1.158  -29.769 -2.318  1.00 25.80 ? 48  ILE A CB  1 
ATOM   147  C CG1 . ILE A 1 21  ? 1.973  -29.853 -3.618  1.00 28.65 ? 48  ILE A CG1 1 
ATOM   148  C CG2 . ILE A 1 21  ? 1.819  -30.517 -1.162  1.00 26.33 ? 48  ILE A CG2 1 
ATOM   149  C CD1 . ILE A 1 21  ? 3.254  -29.029 -3.626  1.00 28.63 ? 48  ILE A CD1 1 
ATOM   150  N N   . LYS A 1 22  ? -1.565 -29.712 -0.556  1.00 22.92 ? 49  LYS A N   1 
ATOM   151  C CA  . LYS A 1 22  ? -2.257 -29.997 0.697   1.00 26.86 ? 49  LYS A CA  1 
ATOM   152  C C   . LYS A 1 22  ? -3.396 -31.008 0.481   1.00 26.60 ? 49  LYS A C   1 
ATOM   153  O O   . LYS A 1 22  ? -3.539 -31.984 1.230   1.00 25.96 ? 49  LYS A O   1 
ATOM   154  C CB  . LYS A 1 22  ? -2.743 -28.685 1.319   1.00 30.21 ? 49  LYS A CB  1 
ATOM   155  C CG  . LYS A 1 22  ? -3.164 -28.769 2.786   1.00 36.76 ? 49  LYS A CG  1 
ATOM   156  C CD  . LYS A 1 22  ? -3.720 -27.469 3.370   1.00 41.01 ? 49  LYS A CD  1 
ATOM   157  C CE  . LYS A 1 22  ? -4.368 -27.594 4.742   1.00 42.49 ? 49  LYS A CE  1 
ATOM   158  N NZ  . LYS A 1 22  ? -5.496 -28.543 4.729   1.00 45.29 ? 49  LYS A NZ  1 
ATOM   159  N N   . THR A 1 23  ? -4.216 -30.777 -0.547  1.00 25.26 ? 50  THR A N   1 
ATOM   160  C CA  . THR A 1 23  ? -5.301 -31.692 -0.893  1.00 28.06 ? 50  THR A CA  1 
ATOM   161  C C   . THR A 1 23  ? -4.748 -33.079 -1.245  1.00 28.25 ? 50  THR A C   1 
ATOM   162  O O   . THR A 1 23  ? -5.196 -34.102 -0.722  1.00 29.43 ? 50  THR A O   1 
ATOM   163  C CB  . THR A 1 23  ? -6.107 -31.111 -2.058  1.00 25.35 ? 50  THR A CB  1 
ATOM   164  O OG1 . THR A 1 23  ? -6.638 -29.903 -1.524  1.00 24.05 ? 50  THR A OG1 1 
ATOM   165  C CG2 . THR A 1 23  ? -7.211 -32.043 -2.517  1.00 22.96 ? 50  THR A CG2 1 
ATOM   166  N N   . PHE A 1 24  ? -3.764 -33.105 -2.148  1.00 29.66 ? 51  PHE A N   1 
ATOM   167  C CA  . PHE A 1 24  ? -3.171 -34.354 -2.592  1.00 26.45 ? 51  PHE A CA  1 
ATOM   168  C C   . PHE A 1 24  ? -2.601 -35.139 -1.405  1.00 26.41 ? 51  PHE A C   1 
ATOM   169  O O   . PHE A 1 24  ? -2.785 -36.356 -1.320  1.00 25.88 ? 51  PHE A O   1 
ATOM   170  C CB  . PHE A 1 24  ? -2.173 -34.065 -3.724  1.00 27.32 ? 51  PHE A CB  1 
ATOM   171  C CG  . PHE A 1 24  ? -1.452 -35.304 -4.229  1.00 27.05 ? 51  PHE A CG  1 
ATOM   172  C CD1 . PHE A 1 24  ? -2.164 -36.439 -4.589  1.00 28.32 ? 51  PHE A CD1 1 
ATOM   173  C CD2 . PHE A 1 24  ? -0.064 -35.362 -4.252  1.00 27.50 ? 51  PHE A CD2 1 
ATOM   174  C CE1 . PHE A 1 24  ? -1.506 -37.578 -5.040  1.00 31.54 ? 51  PHE A CE1 1 
ATOM   175  C CE2 . PHE A 1 24  ? 0.589  -36.493 -4.703  1.00 29.77 ? 51  PHE A CE2 1 
ATOM   176  C CZ  . PHE A 1 24  ? -0.126 -37.610 -5.081  1.00 30.59 ? 51  PHE A CZ  1 
ATOM   177  N N   . ARG A 1 25  ? -1.933 -34.474 -0.456  1.00 27.01 ? 52  ARG A N   1 
ATOM   178  C CA  . ARG A 1 25  ? -1.469 -35.176 0.732   1.00 26.83 ? 52  ARG A CA  1 
ATOM   179  C C   . ARG A 1 25  ? -2.630 -35.664 1.598   1.00 26.46 ? 52  ARG A C   1 
ATOM   180  O O   . ARG A 1 25  ? -2.541 -36.717 2.234   1.00 23.97 ? 52  ARG A O   1 
ATOM   181  C CB  . ARG A 1 25  ? -0.507 -34.357 1.588   1.00 25.68 ? 52  ARG A CB  1 
ATOM   182  C CG  . ARG A 1 25  ? 0.826  -34.208 0.876   1.00 24.45 ? 52  ARG A CG  1 
ATOM   183  C CD  . ARG A 1 25  ? 1.822  -33.505 1.722   1.00 24.99 ? 52  ARG A CD  1 
ATOM   184  N NE  . ARG A 1 25  ? 2.340  -34.268 2.855   1.00 28.03 ? 52  ARG A NE  1 
ATOM   185  C CZ  . ARG A 1 25  ? 3.241  -33.795 3.705   1.00 30.97 ? 52  ARG A CZ  1 
ATOM   186  N NH1 . ARG A 1 25  ? 3.643  -32.545 3.600   1.00 33.96 ? 52  ARG A NH1 1 
ATOM   187  N NH2 . ARG A 1 25  ? 3.749  -34.577 4.639   1.00 34.00 ? 52  ARG A NH2 1 
ATOM   188  N N   . GLN A 1 26  ? -3.707 -34.882 1.687   1.00 27.93 ? 53  GLN A N   1 
ATOM   189  C CA  . GLN A 1 26  ? -4.816 -35.299 2.523   1.00 29.90 ? 53  GLN A CA  1 
ATOM   190  C C   . GLN A 1 26  ? -5.468 -36.562 1.948   1.00 27.79 ? 53  GLN A C   1 
ATOM   191  O O   . GLN A 1 26  ? -5.877 -37.432 2.705   1.00 29.05 ? 53  GLN A O   1 
ATOM   192  C CB  . GLN A 1 26  ? -5.791 -34.147 2.761   1.00 33.88 ? 53  GLN A CB  1 
ATOM   193  C CG  . GLN A 1 26  ? -6.747 -34.403 3.923   1.00 44.73 ? 53  GLN A CG  1 
ATOM   194  C CD  . GLN A 1 26  ? -6.085 -34.477 5.289   1.00 48.64 ? 53  GLN A CD  1 
ATOM   195  O OE1 . GLN A 1 26  ? -6.183 -35.486 6.001   1.00 52.16 ? 53  GLN A OE1 1 
ATOM   196  N NE2 . GLN A 1 26  ? -5.452 -33.388 5.700   1.00 46.91 ? 53  GLN A NE2 1 
ATOM   197  N N   . GLN A 1 27  ? -5.582 -36.666 0.624   1.00 27.16 ? 54  GLN A N   1 
ATOM   198  C CA  . GLN A 1 27  ? -6.232 -37.806 -0.003  1.00 26.99 ? 54  GLN A CA  1 
ATOM   199  C C   . GLN A 1 27  ? -5.277 -38.981 -0.198  1.00 29.42 ? 54  GLN A C   1 
ATOM   200  O O   . GLN A 1 27  ? -5.692 -40.135 -0.217  1.00 25.76 ? 54  GLN A O   1 
ATOM   201  C CB  . GLN A 1 27  ? -6.721 -37.335 -1.368  1.00 31.02 ? 54  GLN A CB  1 
ATOM   202  C CG  . GLN A 1 27  ? -7.774 -36.237 -1.266  1.00 30.20 ? 54  GLN A CG  1 
ATOM   203  C CD  . GLN A 1 27  ? -8.264 -35.751 -2.611  1.00 28.60 ? 54  GLN A CD  1 
ATOM   204  O OE1 . GLN A 1 27  ? -7.589 -35.894 -3.634  1.00 30.23 ? 54  GLN A OE1 1 
ATOM   205  N NE2 . GLN A 1 27  ? -9.446 -35.154 -2.617  1.00 27.31 ? 54  GLN A NE2 1 
ATOM   206  N N   . HIS A 1 28  ? -3.988 -38.706 -0.391  1.00 27.79 ? 55  HIS A N   1 
ATOM   207  C CA  . HIS A 1 28  ? -3.098 -39.742 -0.881  1.00 29.17 ? 55  HIS A CA  1 
ATOM   208  C C   . HIS A 1 28  ? -1.780 -39.803 -0.122  1.00 30.65 ? 55  HIS A C   1 
ATOM   209  O O   . HIS A 1 28  ? -0.892 -40.557 -0.523  1.00 32.55 ? 55  HIS A O   1 
ATOM   210  C CB  . HIS A 1 28  ? -2.807 -39.506 -2.359  1.00 27.17 ? 55  HIS A CB  1 
ATOM   211  C CG  . HIS A 1 28  ? -3.897 -39.926 -3.256  1.00 29.50 ? 55  HIS A CG  1 
ATOM   212  N ND1 . HIS A 1 28  ? -4.359 -41.222 -3.263  1.00 35.35 ? 55  HIS A ND1 1 
ATOM   213  C CD2 . HIS A 1 28  ? -4.534 -39.285 -4.250  1.00 31.10 ? 55  HIS A CD2 1 
ATOM   214  C CE1 . HIS A 1 28  ? -5.284 -41.343 -4.200  1.00 35.13 ? 55  HIS A CE1 1 
ATOM   215  N NE2 . HIS A 1 28  ? -5.425 -40.169 -4.793  1.00 34.30 ? 55  HIS A NE2 1 
ATOM   216  N N   . GLY A 1 29  ? -1.674 -39.064 0.987   1.00 31.85 ? 56  GLY A N   1 
ATOM   217  C CA  . GLY A 1 29  ? -0.471 -39.062 1.798   1.00 32.20 ? 56  GLY A CA  1 
ATOM   218  C C   . GLY A 1 29  ? 0.018  -40.476 2.124   1.00 34.88 ? 56  GLY A C   1 
ATOM   219  O O   . GLY A 1 29  ? 1.223  -40.740 2.088   1.00 30.43 ? 56  GLY A O   1 
ATOM   220  N N   . LYS A 1 30  ? -0.925 -41.373 2.430   1.00 30.71 ? 57  LYS A N   1 
ATOM   221  C CA  . LYS A 1 30  ? -0.601 -42.705 2.909   1.00 34.15 ? 57  LYS A CA  1 
ATOM   222  C C   . LYS A 1 30  ? -0.509 -43.715 1.768   1.00 31.03 ? 57  LYS A C   1 
ATOM   223  O O   . LYS A 1 30  ? -0.233 -44.892 2.000   1.00 29.46 ? 57  LYS A O   1 
ATOM   224  C CB  . LYS A 1 30  ? -1.638 -43.163 3.933   1.00 41.61 ? 57  LYS A CB  1 
ATOM   225  C CG  . LYS A 1 30  ? -1.614 -42.454 5.287   1.00 45.42 ? 57  LYS A CG  1 
ATOM   226  C CD  . LYS A 1 30  ? -2.895 -42.766 6.058   1.00 53.48 ? 57  LYS A CD  1 
ATOM   227  C CE  . LYS A 1 30  ? -2.989 -42.129 7.408   1.00 59.93 ? 57  LYS A CE  1 
ATOM   228  N NZ  . LYS A 1 30  ? -2.234 -42.862 8.430   1.00 60.06 ? 57  LYS A NZ  1 
ATOM   229  N N   . THR A 1 31  ? -0.712 -43.260 0.533   1.00 27.79 ? 58  THR A N   1 
ATOM   230  C CA  . THR A 1 31  ? -0.579 -44.125 -0.625  1.00 28.31 ? 58  THR A CA  1 
ATOM   231  C C   . THR A 1 31  ? 0.878  -44.561 -0.820  1.00 31.21 ? 58  THR A C   1 
ATOM   232  O O   . THR A 1 31  ? 1.798  -43.743 -0.832  1.00 25.84 ? 58  THR A O   1 
ATOM   233  C CB  . THR A 1 31  ? -1.114 -43.409 -1.855  1.00 27.01 ? 58  THR A CB  1 
ATOM   234  O OG1 . THR A 1 31  ? -2.457 -43.048 -1.534  1.00 29.34 ? 58  THR A OG1 1 
ATOM   235  C CG2 . THR A 1 31  ? -1.071 -44.276 -3.104  1.00 27.04 ? 58  THR A CG2 1 
ATOM   236  N N   . VAL A 1 32  ? 1.067  -45.869 -1.014  1.00 33.44 ? 59  VAL A N   1 
ATOM   237  C CA  . VAL A 1 32  ? 2.384  -46.436 -1.254  1.00 30.12 ? 59  VAL A CA  1 
ATOM   238  C C   . VAL A 1 32  ? 2.746  -46.247 -2.726  1.00 31.27 ? 59  VAL A C   1 
ATOM   239  O O   . VAL A 1 32  ? 1.979  -46.585 -3.612  1.00 29.86 ? 59  VAL A O   1 
ATOM   240  C CB  . VAL A 1 32  ? 2.353  -47.913 -0.828  1.00 32.36 ? 59  VAL A CB  1 
ATOM   241  C CG1 . VAL A 1 32  ? 3.621  -48.658 -1.241  1.00 35.73 ? 59  VAL A CG1 1 
ATOM   242  C CG2 . VAL A 1 32  ? 2.107  -48.059 0.676   1.00 31.03 ? 59  VAL A CG2 1 
ATOM   243  N N   . VAL A 1 33  ? 3.920  -45.678 -3.000  1.00 30.76 ? 60  VAL A N   1 
ATOM   244  C CA  . VAL A 1 33  ? 4.323  -45.459 -4.380  1.00 32.44 ? 60  VAL A CA  1 
ATOM   245  C C   . VAL A 1 33  ? 5.533  -46.331 -4.729  1.00 29.04 ? 60  VAL A C   1 
ATOM   246  O O   . VAL A 1 33  ? 5.920  -46.377 -5.891  1.00 32.46 ? 60  VAL A O   1 
ATOM   247  C CB  . VAL A 1 33  ? 4.595  -43.976 -4.698  1.00 35.23 ? 60  VAL A CB  1 
ATOM   248  C CG1 . VAL A 1 33  ? 3.309  -43.160 -4.734  1.00 42.40 ? 60  VAL A CG1 1 
ATOM   249  C CG2 . VAL A 1 33  ? 5.578  -43.340 -3.739  1.00 39.07 ? 60  VAL A CG2 1 
ATOM   250  N N   . GLY A 1 34  ? 6.149  -46.986 -3.742  1.00 28.17 ? 61  GLY A N   1 
ATOM   251  C CA  . GLY A 1 34  ? 7.161  -47.992 -4.035  1.00 30.87 ? 61  GLY A CA  1 
ATOM   252  C C   . GLY A 1 34  ? 7.606  -48.723 -2.777  1.00 30.58 ? 61  GLY A C   1 
ATOM   253  O O   . GLY A 1 34  ? 7.203  -48.375 -1.667  1.00 34.25 ? 61  GLY A O   1 
ATOM   254  N N   . GLN A 1 35  ? 8.464  -49.732 -2.966  1.00 33.75 ? 62  GLN A N   1 
ATOM   255  C CA  . GLN A 1 35  ? 8.976  -50.537 -1.868  1.00 34.49 ? 62  GLN A CA  1 
ATOM   256  C C   . GLN A 1 35  ? 10.487 -50.315 -1.786  1.00 31.56 ? 62  GLN A C   1 
ATOM   257  O O   . GLN A 1 35  ? 11.137 -50.040 -2.796  1.00 31.48 ? 62  GLN A O   1 
ATOM   258  C CB  . GLN A 1 35  ? 8.691  -52.022 -2.095  1.00 38.16 ? 62  GLN A CB  1 
ATOM   259  C CG  . GLN A 1 35  ? 7.423  -52.333 -2.880  1.00 45.60 ? 62  GLN A CG  1 
ATOM   260  C CD  . GLN A 1 35  ? 6.215  -52.499 -1.993  1.00 52.59 ? 62  GLN A CD  1 
ATOM   261  O OE1 . GLN A 1 35  ? 5.202  -51.802 -2.135  1.00 61.12 ? 62  GLN A OE1 1 
ATOM   262  N NE2 . GLN A 1 35  ? 6.321  -53.438 -1.064  1.00 55.71 ? 62  GLN A NE2 1 
ATOM   263  N N   . ILE A 1 36  ? 11.043 -50.420 -0.584  1.00 29.61 ? 63  ILE A N   1 
ATOM   264  C CA  . ILE A 1 36  ? 12.485 -50.299 -0.416  1.00 28.79 ? 63  ILE A CA  1 
ATOM   265  C C   . ILE A 1 36  ? 13.011 -51.705 -0.171  1.00 26.49 ? 63  ILE A C   1 
ATOM   266  O O   . ILE A 1 36  ? 12.501 -52.368 0.719   1.00 27.13 ? 63  ILE A O   1 
ATOM   267  C CB  . ILE A 1 36  ? 12.832 -49.408 0.787   1.00 29.70 ? 63  ILE A CB  1 
ATOM   268  C CG1 . ILE A 1 36  ? 12.289 -47.997 0.600   1.00 31.24 ? 63  ILE A CG1 1 
ATOM   269  C CG2 . ILE A 1 36  ? 14.343 -49.421 1.077   1.00 29.42 ? 63  ILE A CG2 1 
ATOM   270  C CD1 . ILE A 1 36  ? 12.118 -47.251 1.905   1.00 29.23 ? 63  ILE A CD1 1 
ATOM   271  N N   . THR A 1 37  ? 14.010 -52.127 -0.947  1.00 28.27 ? 64  THR A N   1 
ATOM   272  C CA  . THR A 1 37  ? 14.643 -53.424 -0.766  1.00 27.23 ? 64  THR A CA  1 
ATOM   273  C C   . THR A 1 37  ? 16.038 -53.223 -0.183  1.00 26.83 ? 64  THR A C   1 
ATOM   274  O O   . THR A 1 37  ? 16.624 -52.141 -0.277  1.00 21.78 ? 64  THR A O   1 
ATOM   275  C CB  . THR A 1 37  ? 14.740 -54.170 -2.097  1.00 29.49 ? 64  THR A CB  1 
ATOM   276  O OG1 . THR A 1 37  ? 15.505 -53.336 -2.949  1.00 31.04 ? 64  THR A OG1 1 
ATOM   277  C CG2 . THR A 1 37  ? 13.410 -54.415 -2.778  1.00 34.95 ? 64  THR A CG2 1 
ATOM   278  N N   . VAL A 1 38  ? 16.603 -54.319 0.337   1.00 27.99 ? 65  VAL A N   1 
ATOM   279  C CA  . VAL A 1 38  ? 17.964 -54.324 0.844   1.00 28.55 ? 65  VAL A CA  1 
ATOM   280  C C   . VAL A 1 38  ? 18.909 -53.801 -0.243  1.00 25.78 ? 65  VAL A C   1 
ATOM   281  O O   . VAL A 1 38  ? 19.818 -53.022 0.053   1.00 25.63 ? 65  VAL A O   1 
ATOM   282  C CB  . VAL A 1 38  ? 18.365 -55.726 1.356   1.00 30.75 ? 65  VAL A CB  1 
ATOM   283  C CG1 . VAL A 1 38  ? 19.870 -55.854 1.584   1.00 33.07 ? 65  VAL A CG1 1 
ATOM   284  C CG2 . VAL A 1 38  ? 17.596 -56.088 2.622   1.00 28.05 ? 65  VAL A CG2 1 
ATOM   285  N N   . ASP A 1 39  ? 18.688 -54.218 -1.496  1.00 25.74 ? 66  ASP A N   1 
ATOM   286  C CA  . ASP A 1 39  ? 19.576 -53.871 -2.595  1.00 25.00 ? 66  ASP A CA  1 
ATOM   287  C C   . ASP A 1 39  ? 19.524 -52.377 -2.885  1.00 26.34 ? 66  ASP A C   1 
ATOM   288  O O   . ASP A 1 39  ? 20.501 -51.847 -3.388  1.00 26.59 ? 66  ASP A O   1 
ATOM   289  C CB  . ASP A 1 39  ? 19.288 -54.648 -3.874  1.00 28.02 ? 66  ASP A CB  1 
ATOM   290  C CG  . ASP A 1 39  ? 19.950 -56.019 -3.986  1.00 30.88 ? 66  ASP A CG  1 
ATOM   291  O OD1 . ASP A 1 39  ? 20.852 -56.325 -3.171  1.00 27.92 ? 66  ASP A OD1 1 
ATOM   292  O OD2 . ASP A 1 39  ? 19.560 -56.771 -4.894  1.00 34.29 ? 66  ASP A OD2 1 
ATOM   293  N N   . MET A 1 40  ? 18.385 -51.715 -2.622  1.00 27.73 ? 67  MET A N   1 
ATOM   294  C CA  . MET A 1 40  ? 18.262 -50.293 -2.904  1.00 29.65 ? 67  MET A CA  1 
ATOM   295  C C   . MET A 1 40  ? 19.091 -49.525 -1.884  1.00 27.79 ? 67  MET A C   1 
ATOM   296  O O   . MET A 1 40  ? 19.757 -48.563 -2.233  1.00 35.29 ? 67  MET A O   1 
ATOM   297  C CB  . MET A 1 40  ? 16.807 -49.796 -2.870  1.00 32.41 ? 67  MET A CB  1 
ATOM   298  C CG  . MET A 1 40  ? 15.918 -50.295 -4.004  1.00 34.71 ? 67  MET A CG  1 
ATOM   299  S SD  . MET A 1 40  ? 14.169 -49.858 -3.793  1.00 38.81 ? 67  MET A SD  1 
ATOM   300  C CE  . MET A 1 40  ? 13.426 -51.063 -4.899  1.00 38.05 ? 67  MET A CE  1 
ATOM   301  N N   . MET A 1 41  ? 19.060 -49.979 -0.635  1.00 26.17 ? 68  MET A N   1 
ATOM   302  C CA  . MET A 1 41  ? 19.843 -49.377 0.429   1.00 27.46 ? 68  MET A CA  1 
ATOM   303  C C   . MET A 1 41  ? 21.341 -49.485 0.152   1.00 28.46 ? 68  MET A C   1 
ATOM   304  O O   . MET A 1 41  ? 22.038 -48.490 0.296   1.00 30.99 ? 68  MET A O   1 
ATOM   305  C CB  . MET A 1 41  ? 19.496 -50.011 1.771   1.00 28.51 ? 68  MET A CB  1 
ATOM   306  C CG  . MET A 1 41  ? 18.019 -49.873 2.104   1.00 28.29 ? 68  MET A CG  1 
ATOM   307  S SD  . MET A 1 41  ? 17.706 -50.443 3.778   1.00 29.12 ? 68  MET A SD  1 
ATOM   308  C CE  . MET A 1 41  ? 18.650 -49.336 4.839   1.00 30.82 ? 68  MET A CE  1 
ATOM   309  N N   . TYR A 1 42  ? 21.819 -50.669 -0.258  1.00 26.54 ? 69  TYR A N   1 
ATOM   310  C CA  . TYR A 1 42  ? 23.218 -50.849 -0.632  1.00 28.97 ? 69  TYR A CA  1 
ATOM   311  C C   . TYR A 1 42  ? 23.528 -50.183 -1.974  1.00 27.22 ? 69  TYR A C   1 
ATOM   312  O O   . TYR A 1 42  ? 24.683 -49.851 -2.221  1.00 30.75 ? 69  TYR A O   1 
ATOM   313  C CB  . TYR A 1 42  ? 23.661 -52.321 -0.703  1.00 25.14 ? 69  TYR A CB  1 
ATOM   314  C CG  . TYR A 1 42  ? 23.857 -52.938 0.674   1.00 27.46 ? 69  TYR A CG  1 
ATOM   315  C CD1 . TYR A 1 42  ? 24.998 -52.691 1.432   1.00 27.87 ? 69  TYR A CD1 1 
ATOM   316  C CD2 . TYR A 1 42  ? 22.922 -53.820 1.191   1.00 25.21 ? 69  TYR A CD2 1 
ATOM   317  C CE1 . TYR A 1 42  ? 25.183 -53.275 2.675   1.00 25.31 ? 69  TYR A CE1 1 
ATOM   318  C CE2 . TYR A 1 42  ? 23.085 -54.394 2.436   1.00 23.43 ? 69  TYR A CE2 1 
ATOM   319  C CZ  . TYR A 1 42  ? 24.213 -54.121 3.178   1.00 25.24 ? 69  TYR A CZ  1 
ATOM   320  O OH  . TYR A 1 42  ? 24.272 -54.708 4.401   1.00 26.90 ? 69  TYR A OH  1 
ATOM   321  N N   . GLY A 1 43  ? 22.524 -50.050 -2.852  1.00 28.05 ? 70  GLY A N   1 
ATOM   322  C CA  . GLY A 1 43  ? 22.737 -49.631 -4.231  1.00 27.15 ? 70  GLY A CA  1 
ATOM   323  C C   . GLY A 1 43  ? 22.397 -48.152 -4.474  1.00 25.79 ? 70  GLY A C   1 
ATOM   324  O O   . GLY A 1 43  ? 21.968 -47.778 -5.562  1.00 24.00 ? 70  GLY A O   1 
ATOM   325  N N   . GLY A 1 44  ? 22.648 -47.303 -3.480  1.00 25.14 ? 71  GLY A N   1 
ATOM   326  C CA  . GLY A 1 44  ? 22.557 -45.866 -3.665  1.00 26.81 ? 71  GLY A CA  1 
ATOM   327  C C   . GLY A 1 44  ? 21.134 -45.434 -3.984  1.00 27.03 ? 71  GLY A C   1 
ATOM   328  O O   . GLY A 1 44  ? 20.944 -44.537 -4.784  1.00 28.98 ? 71  GLY A O   1 
ATOM   329  N N   . MET A 1 45  ? 20.154 -46.082 -3.347  1.00 31.25 ? 72  MET A N   1 
ATOM   330  C CA  . MET A 1 45  ? 18.748 -45.740 -3.493  1.00 31.03 ? 72  MET A CA  1 
ATOM   331  C C   . MET A 1 45  ? 18.302 -45.878 -4.952  1.00 34.03 ? 72  MET A C   1 
ATOM   332  O O   . MET A 1 45  ? 17.309 -45.276 -5.350  1.00 31.44 ? 72  MET A O   1 
ATOM   333  C CB  . MET A 1 45  ? 18.448 -44.306 -3.028  1.00 30.70 ? 72  MET A CB  1 
ATOM   334  C CG  . MET A 1 45  ? 18.853 -43.946 -1.601  1.00 34.82 ? 72  MET A CG  1 
ATOM   335  S SD  . MET A 1 45  ? 18.578 -42.180 -1.295  1.00 36.86 ? 72  MET A SD  1 
ATOM   336  C CE  . MET A 1 45  ? 19.263 -41.807 0.326   1.00 36.79 ? 72  MET A CE  1 
ATOM   337  N N   . ARG A 1 46  ? 19.015 -46.685 -5.754  1.00 37.00 ? 73  ARG A N   1 
ATOM   338  C CA  . ARG A 1 46  ? 18.677 -46.875 -7.159  1.00 39.93 ? 73  ARG A CA  1 
ATOM   339  C C   . ARG A 1 46  ? 17.199 -47.257 -7.281  1.00 35.35 ? 73  ARG A C   1 
ATOM   340  O O   . ARG A 1 46  ? 16.742 -48.181 -6.615  1.00 30.17 ? 73  ARG A O   1 
ATOM   341  C CB  . ARG A 1 46  ? 19.567 -47.980 -7.747  1.00 47.72 ? 73  ARG A CB  1 
ATOM   342  C CG  . ARG A 1 46  ? 19.499 -48.202 -9.250  1.00 56.02 ? 73  ARG A CG  1 
ATOM   343  C CD  . ARG A 1 46  ? 20.247 -49.500 -9.638  1.00 64.24 ? 73  ARG A CD  1 
ATOM   344  N NE  . ARG A 1 46  ? 20.598 -49.577 -11.063 1.00 67.74 ? 73  ARG A NE  1 
ATOM   345  C CZ  . ARG A 1 46  ? 21.561 -48.879 -11.664 1.00 77.13 ? 73  ARG A CZ  1 
ATOM   346  N NH1 . ARG A 1 46  ? 22.425 -48.169 -10.960 1.00 76.69 ? 73  ARG A NH1 1 
ATOM   347  N NH2 . ARG A 1 46  ? 21.686 -48.915 -12.979 1.00 84.86 ? 73  ARG A NH2 1 
ATOM   348  N N   . GLY A 1 47  ? 16.465 -46.481 -8.087  1.00 34.42 ? 74  GLY A N   1 
ATOM   349  C CA  . GLY A 1 47  ? 15.065 -46.725 -8.395  1.00 35.48 ? 74  GLY A CA  1 
ATOM   350  C C   . GLY A 1 47  ? 14.118 -46.454 -7.221  1.00 40.06 ? 74  GLY A C   1 
ATOM   351  O O   . GLY A 1 47  ? 12.948 -46.811 -7.279  1.00 40.76 ? 74  GLY A O   1 
ATOM   352  N N   . MET A 1 48  ? 14.622 -45.836 -6.150  1.00 34.35 ? 75  MET A N   1 
ATOM   353  C CA  . MET A 1 48  ? 13.788 -45.444 -5.035  1.00 35.78 ? 75  MET A CA  1 
ATOM   354  C C   . MET A 1 48  ? 13.176 -44.070 -5.338  1.00 35.44 ? 75  MET A C   1 
ATOM   355  O O   . MET A 1 48  ? 13.866 -43.137 -5.748  1.00 34.74 ? 75  MET A O   1 
ATOM   356  C CB  . MET A 1 48  ? 14.656 -45.451 -3.778  1.00 40.99 ? 75  MET A CB  1 
ATOM   357  C CG  . MET A 1 48  ? 13.909 -45.473 -2.475  1.00 47.06 ? 75  MET A CG  1 
ATOM   358  S SD  . MET A 1 48  ? 15.035 -45.300 -1.075  1.00 48.41 ? 75  MET A SD  1 
ATOM   359  C CE  . MET A 1 48  ? 15.936 -46.787 -1.520  1.00 43.06 ? 75  MET A CE  1 
ATOM   360  N N   . LYS A 1 49  ? 11.855 -43.953 -5.190  1.00 34.11 ? 76  LYS A N   1 
ATOM   361  C CA  . LYS A 1 49  ? 11.185 -42.672 -5.319  1.00 36.46 ? 76  LYS A CA  1 
ATOM   362  C C   . LYS A 1 49  ? 11.428 -41.940 -3.999  1.00 36.29 ? 76  LYS A C   1 
ATOM   363  O O   . LYS A 1 49  ? 10.960 -42.353 -2.947  1.00 41.97 ? 76  LYS A O   1 
ATOM   364  C CB  . LYS A 1 49  ? 9.741  -42.913 -5.783  1.00 42.70 ? 76  LYS A CB  1 
ATOM   365  C CG  . LYS A 1 49  ? 9.692  -43.439 -7.227  1.00 48.53 ? 76  LYS A CG  1 
ATOM   366  C CD  . LYS A 1 49  ? 8.402  -44.062 -7.747  1.00 57.85 ? 76  LYS A CD  1 
ATOM   367  C CE  . LYS A 1 49  ? 7.482  -43.057 -8.333  1.00 64.96 ? 76  LYS A CE  1 
ATOM   368  N NZ  . LYS A 1 49  ? 6.997  -42.142 -7.294  1.00 74.27 ? 76  LYS A NZ  1 
ATOM   369  N N   . GLY A 1 50  ? 12.262 -40.909 -4.043  1.00 30.94 ? 77  GLY A N   1 
ATOM   370  C CA  . GLY A 1 50  ? 12.897 -40.428 -2.831  1.00 29.38 ? 77  GLY A CA  1 
ATOM   371  C C   . GLY A 1 50  ? 12.518 -38.993 -2.504  1.00 29.57 ? 77  GLY A C   1 
ATOM   372  O O   . GLY A 1 50  ? 12.540 -38.600 -1.338  1.00 32.52 ? 77  GLY A O   1 
ATOM   373  N N   . LEU A 1 51  ? 12.246 -38.180 -3.526  1.00 28.50 ? 78  LEU A N   1 
ATOM   374  C CA  . LEU A 1 51  ? 11.985 -36.781 -3.227  1.00 28.06 ? 78  LEU A CA  1 
ATOM   375  C C   . LEU A 1 51  ? 11.047 -36.215 -4.266  1.00 23.33 ? 78  LEU A C   1 
ATOM   376  O O   . LEU A 1 51  ? 10.876 -36.777 -5.340  1.00 21.29 ? 78  LEU A O   1 
ATOM   377  C CB  . LEU A 1 51  ? 13.274 -35.964 -3.129  1.00 30.66 ? 78  LEU A CB  1 
ATOM   378  C CG  . LEU A 1 51  ? 14.143 -35.911 -4.386  1.00 30.92 ? 78  LEU A CG  1 
ATOM   379  C CD1 . LEU A 1 51  ? 15.142 -34.761 -4.264  1.00 34.41 ? 78  LEU A CD1 1 
ATOM   380  C CD2 . LEU A 1 51  ? 14.874 -37.226 -4.566  1.00 31.60 ? 78  LEU A CD2 1 
ATOM   381  N N   . VAL A 1 52  ? 10.477 -35.069 -3.913  1.00 25.48 ? 79  VAL A N   1 
ATOM   382  C CA  . VAL A 1 52  ? 9.658  -34.286 -4.813  1.00 22.59 ? 79  VAL A CA  1 
ATOM   383  C C   . VAL A 1 52  ? 10.494 -33.106 -5.285  1.00 23.43 ? 79  VAL A C   1 
ATOM   384  O O   . VAL A 1 52  ? 11.071 -32.386 -4.482  1.00 24.60 ? 79  VAL A O   1 
ATOM   385  C CB  . VAL A 1 52  ? 8.374  -33.853 -4.092  1.00 25.23 ? 79  VAL A CB  1 
ATOM   386  C CG1 . VAL A 1 52  ? 7.507  -32.955 -4.964  1.00 23.62 ? 79  VAL A CG1 1 
ATOM   387  C CG2 . VAL A 1 52  ? 7.603  -35.083 -3.601  1.00 28.13 ? 79  VAL A CG2 1 
ATOM   388  N N   . TYR A 1 53  ? 10.541 -32.953 -6.600  1.00 21.65 ? 80  TYR A N   1 
ATOM   389  C CA  . TYR A 1 53  ? 11.394 -32.009 -7.278  1.00 24.08 ? 80  TYR A CA  1 
ATOM   390  C C   . TYR A 1 53  ? 10.578 -31.573 -8.484  1.00 23.88 ? 80  TYR A C   1 
ATOM   391  O O   . TYR A 1 53  ? 10.239 -32.397 -9.330  1.00 21.04 ? 80  TYR A O   1 
ATOM   392  C CB  . TYR A 1 53  ? 12.746 -32.718 -7.477  1.00 26.78 ? 80  TYR A CB  1 
ATOM   393  C CG  . TYR A 1 53  ? 13.852 -31.810 -7.970  1.00 28.29 ? 80  TYR A CG  1 
ATOM   394  C CD1 . TYR A 1 53  ? 13.907 -31.442 -9.309  1.00 29.00 ? 80  TYR A CD1 1 
ATOM   395  C CD2 . TYR A 1 53  ? 14.832 -31.315 -7.107  1.00 30.05 ? 80  TYR A CD2 1 
ATOM   396  C CE1 . TYR A 1 53  ? 14.905 -30.602 -9.776  1.00 29.63 ? 80  TYR A CE1 1 
ATOM   397  C CE2 . TYR A 1 53  ? 15.825 -30.458 -7.562  1.00 28.51 ? 80  TYR A CE2 1 
ATOM   398  C CZ  . TYR A 1 53  ? 15.860 -30.103 -8.906  1.00 31.26 ? 80  TYR A CZ  1 
ATOM   399  O OH  . TYR A 1 53  ? 16.816 -29.266 -9.426  1.00 30.95 ? 80  TYR A OH  1 
ATOM   400  N N   . GLU A 1 54  ? 10.202 -30.290 -8.500  1.00 25.18 ? 81  GLU A N   1 
ATOM   401  C CA  . GLU A 1 54  ? 9.156  -29.822 -9.397  1.00 27.34 ? 81  GLU A CA  1 
ATOM   402  C C   . GLU A 1 54  ? 9.682  -29.355 -10.749 1.00 27.41 ? 81  GLU A C   1 
ATOM   403  O O   . GLU A 1 54  ? 8.899  -29.308 -11.691 1.00 27.89 ? 81  GLU A O   1 
ATOM   404  C CB  . GLU A 1 54  ? 8.440  -28.632 -8.766  1.00 28.81 ? 81  GLU A CB  1 
ATOM   405  C CG  . GLU A 1 54  ? 7.866  -28.949 -7.386  1.00 29.79 ? 81  GLU A CG  1 
ATOM   406  C CD  . GLU A 1 54  ? 6.617  -29.817 -7.419  1.00 32.00 ? 81  GLU A CD  1 
ATOM   407  O OE1 . GLU A 1 54  ? 6.302  -30.420 -8.472  1.00 29.74 ? 81  GLU A OE1 1 
ATOM   408  O OE2 . GLU A 1 54  ? 5.939  -29.878 -6.368  1.00 39.29 ? 81  GLU A OE2 1 
ATOM   409  N N   . THR A 1 55  ? 10.962 -28.940 -10.833 1.00 27.47 ? 82  THR A N   1 
ATOM   410  C CA  . THR A 1 55  ? 11.401 -28.109 -11.945 1.00 25.86 ? 82  THR A CA  1 
ATOM   411  C C   . THR A 1 55  ? 11.543 -28.936 -13.218 1.00 26.30 ? 82  THR A C   1 
ATOM   412  O O   . THR A 1 55  ? 11.261 -28.430 -14.298 1.00 27.50 ? 82  THR A O   1 
ATOM   413  C CB  . THR A 1 55  ? 12.690 -27.364 -11.605 1.00 26.17 ? 82  THR A CB  1 
ATOM   414  O OG1 . THR A 1 55  ? 13.646 -28.268 -11.051 1.00 23.95 ? 82  THR A OG1 1 
ATOM   415  C CG2 . THR A 1 55  ? 12.413 -26.272 -10.589 1.00 27.77 ? 82  THR A CG2 1 
ATOM   416  N N   . SER A 1 56  ? 11.971 -30.196 -13.067 1.00 29.05 ? 83  SER A N   1 
ATOM   417  C CA  . SER A 1 56  ? 12.235 -31.083 -14.189 1.00 28.37 ? 83  SER A CA  1 
ATOM   418  C C   . SER A 1 56  ? 11.997 -32.531 -13.760 1.00 26.13 ? 83  SER A C   1 
ATOM   419  O O   . SER A 1 56  ? 12.078 -32.888 -12.582 1.00 27.46 ? 83  SER A O   1 
ATOM   420  C CB  . SER A 1 56  ? 13.631 -30.896 -14.749 1.00 28.18 ? 83  SER A CB  1 
ATOM   421  O OG  . SER A 1 56  ? 14.629 -31.252 -13.805 1.00 25.88 ? 83  SER A OG  1 
ATOM   422  N N   . VAL A 1 57  ? 11.651 -33.347 -14.748 1.00 26.87 ? 84  VAL A N   1 
ATOM   423  C CA  . VAL A 1 57  ? 11.341 -34.751 -14.552 1.00 30.09 ? 84  VAL A CA  1 
ATOM   424  C C   . VAL A 1 57  ? 12.056 -35.544 -15.638 1.00 28.98 ? 84  VAL A C   1 
ATOM   425  O O   . VAL A 1 57  ? 11.833 -35.324 -16.814 1.00 27.53 ? 84  VAL A O   1 
ATOM   426  C CB  . VAL A 1 57  ? 9.818  -34.998 -14.626 1.00 35.14 ? 84  VAL A CB  1 
ATOM   427  C CG1 . VAL A 1 57  ? 9.496  -36.489 -14.685 1.00 34.78 ? 84  VAL A CG1 1 
ATOM   428  C CG2 . VAL A 1 57  ? 9.083  -34.333 -13.467 1.00 35.28 ? 84  VAL A CG2 1 
ATOM   429  N N   . LEU A 1 58  ? 12.920 -36.476 -15.256 1.00 38.83 ? 85  LEU A N   1 
ATOM   430  C CA  . LEU A 1 58  ? 13.639 -37.237 -16.263 1.00 40.30 ? 85  LEU A CA  1 
ATOM   431  C C   . LEU A 1 58  ? 12.834 -38.497 -16.562 1.00 45.37 ? 85  LEU A C   1 
ATOM   432  O O   . LEU A 1 58  ? 12.730 -39.387 -15.716 1.00 49.07 ? 85  LEU A O   1 
ATOM   433  C CB  . LEU A 1 58  ? 15.059 -37.575 -15.817 1.00 39.83 ? 85  LEU A CB  1 
ATOM   434  C CG  . LEU A 1 58  ? 15.817 -38.538 -16.737 1.00 39.39 ? 85  LEU A CG  1 
ATOM   435  C CD1 . LEU A 1 58  ? 15.932 -37.985 -18.148 1.00 36.08 ? 85  LEU A CD1 1 
ATOM   436  C CD2 . LEU A 1 58  ? 17.185 -38.869 -16.168 1.00 42.82 ? 85  LEU A CD2 1 
ATOM   437  N N   . ASP A 1 59  ? 12.248 -38.539 -17.759 1.00 43.30 ? 86  ASP A N   1 
ATOM   438  C CA  . ASP A 1 59  ? 11.516 -39.709 -18.195 1.00 48.56 ? 86  ASP A CA  1 
ATOM   439  C C   . ASP A 1 59  ? 12.503 -40.700 -18.821 1.00 48.32 ? 86  ASP A C   1 
ATOM   440  O O   . ASP A 1 59  ? 13.147 -40.353 -19.813 1.00 48.35 ? 86  ASP A O   1 
ATOM   441  C CB  . ASP A 1 59  ? 10.394 -39.324 -19.145 1.00 51.37 ? 86  ASP A CB  1 
ATOM   442  C CG  . ASP A 1 59  ? 9.987  -40.463 -20.065 1.00 53.11 ? 86  ASP A CG  1 
ATOM   443  O OD1 . ASP A 1 59  ? 9.701  -41.553 -19.529 1.00 51.04 ? 86  ASP A OD1 1 
ATOM   444  O OD2 . ASP A 1 59  ? 10.044 -40.269 -21.302 1.00 56.16 ? 86  ASP A OD2 1 
ATOM   445  N N   . PRO A 1 60  ? 12.640 -41.949 -18.290 1.00 48.39 ? 87  PRO A N   1 
ATOM   446  C CA  . PRO A 1 60  ? 13.623 -42.915 -18.803 1.00 50.39 ? 87  PRO A CA  1 
ATOM   447  C C   . PRO A 1 60  ? 13.724 -43.071 -20.324 1.00 46.18 ? 87  PRO A C   1 
ATOM   448  O O   . PRO A 1 60  ? 14.817 -43.293 -20.835 1.00 50.35 ? 87  PRO A O   1 
ATOM   449  C CB  . PRO A 1 60  ? 13.226 -44.247 -18.109 1.00 49.43 ? 87  PRO A CB  1 
ATOM   450  C CG  . PRO A 1 60  ? 12.599 -43.805 -16.790 1.00 50.35 ? 87  PRO A CG  1 
ATOM   451  C CD  . PRO A 1 60  ? 11.885 -42.491 -17.138 1.00 50.62 ? 87  PRO A CD  1 
ATOM   452  N N   . ASP A 1 61  ? 12.608 -42.917 -21.045 1.00 47.70 ? 88  ASP A N   1 
ATOM   453  C CA  . ASP A 1 61  ? 12.568 -43.222 -22.471 1.00 52.88 ? 88  ASP A CA  1 
ATOM   454  C C   . ASP A 1 61  ? 12.730 -41.999 -23.376 1.00 53.03 ? 88  ASP A C   1 
ATOM   455  O O   . ASP A 1 61  ? 13.218 -42.154 -24.492 1.00 61.02 ? 88  ASP A O   1 
ATOM   456  C CB  . ASP A 1 61  ? 11.313 -43.996 -22.823 1.00 58.16 ? 88  ASP A CB  1 
ATOM   457  C CG  . ASP A 1 61  ? 11.275 -45.393 -22.224 1.00 61.81 ? 88  ASP A CG  1 
ATOM   458  O OD1 . ASP A 1 61  ? 12.206 -46.182 -22.523 1.00 55.08 ? 88  ASP A OD1 1 
ATOM   459  O OD2 . ASP A 1 61  ? 10.335 -45.668 -21.446 1.00 64.99 ? 88  ASP A OD2 1 
ATOM   460  N N   . GLU A 1 62  ? 12.305 -40.804 -22.939 1.00 55.66 ? 89  GLU A N   1 
ATOM   461  C CA  . GLU A 1 62  ? 12.367 -39.612 -23.788 1.00 55.11 ? 89  GLU A CA  1 
ATOM   462  C C   . GLU A 1 62  ? 13.387 -38.594 -23.273 1.00 50.64 ? 89  GLU A C   1 
ATOM   463  O O   . GLU A 1 62  ? 13.712 -37.626 -23.968 1.00 43.93 ? 89  GLU A O   1 
ATOM   464  C CB  . GLU A 1 62  ? 11.007 -38.917 -23.893 1.00 66.18 ? 89  GLU A CB  1 
ATOM   465  C CG  . GLU A 1 62  ? 9.937  -39.783 -24.554 1.00 76.50 ? 89  GLU A CG  1 
ATOM   466  C CD  . GLU A 1 62  ? 10.345 -40.243 -25.942 1.00 82.69 ? 89  GLU A CD  1 
ATOM   467  O OE1 . GLU A 1 62  ? 10.509 -39.370 -26.825 1.00 92.52 ? 89  GLU A OE1 1 
ATOM   468  O OE2 . GLU A 1 62  ? 10.538 -41.463 -26.131 1.00 83.97 ? 89  GLU A OE2 1 
ATOM   469  N N   . GLY A 1 63  ? 13.888 -38.814 -22.051 1.00 45.40 ? 90  GLY A N   1 
ATOM   470  C CA  . GLY A 1 63  ? 14.830 -37.891 -21.447 1.00 42.31 ? 90  GLY A CA  1 
ATOM   471  C C   . GLY A 1 63  ? 14.097 -36.751 -20.745 1.00 37.02 ? 90  GLY A C   1 
ATOM   472  O O   . GLY A 1 63  ? 13.002 -36.937 -20.237 1.00 33.96 ? 90  GLY A O   1 
ATOM   473  N N   . ILE A 1 64  ? 14.723 -35.580 -20.719 1.00 31.89 ? 91  ILE A N   1 
ATOM   474  C CA  . ILE A 1 64  ? 14.407 -34.593 -19.704 1.00 29.99 ? 91  ILE A CA  1 
ATOM   475  C C   . ILE A 1 64  ? 13.266 -33.734 -20.223 1.00 28.31 ? 91  ILE A C   1 
ATOM   476  O O   . ILE A 1 64  ? 13.246 -33.405 -21.395 1.00 29.90 ? 91  ILE A O   1 
ATOM   477  C CB  . ILE A 1 64  ? 15.639 -33.743 -19.336 1.00 27.86 ? 91  ILE A CB  1 
ATOM   478  C CG1 . ILE A 1 64  ? 15.385 -32.871 -18.085 1.00 30.50 ? 91  ILE A CG1 1 
ATOM   479  C CG2 . ILE A 1 64  ? 16.113 -32.894 -20.511 1.00 26.34 ? 91  ILE A CG2 1 
ATOM   480  C CD1 . ILE A 1 64  ? 15.206 -33.673 -16.800 1.00 32.20 ? 91  ILE A CD1 1 
ATOM   481  N N   . ARG A 1 65  ? 12.360 -33.361 -19.320 1.00 32.40 ? 92  ARG A N   1 
ATOM   482  C CA  . ARG A 1 65  ? 11.355 -32.348 -19.589 1.00 31.25 ? 92  ARG A CA  1 
ATOM   483  C C   . ARG A 1 65  ? 11.542 -31.235 -18.566 1.00 26.28 ? 92  ARG A C   1 
ATOM   484  O O   . ARG A 1 65  ? 11.684 -31.479 -17.374 1.00 25.62 ? 92  ARG A O   1 
ATOM   485  C CB  . ARG A 1 65  ? 9.951  -32.978 -19.573 1.00 31.52 ? 92  ARG A CB  1 
ATOM   486  C CG  . ARG A 1 65  ? 9.655  -33.681 -20.889 1.00 38.62 ? 92  ARG A CG  1 
ATOM   487  C CD  . ARG A 1 65  ? 8.465  -34.632 -20.834 1.00 49.24 ? 92  ARG A CD  1 
ATOM   488  N NE  . ARG A 1 65  ? 8.135  -35.205 -22.146 1.00 54.80 ? 92  ARG A NE  1 
ATOM   489  C CZ  . ARG A 1 65  ? 7.638  -34.523 -23.186 1.00 64.29 ? 92  ARG A CZ  1 
ATOM   490  N NH1 . ARG A 1 65  ? 7.286  -33.249 -23.065 1.00 64.75 ? 92  ARG A NH1 1 
ATOM   491  N NH2 . ARG A 1 65  ? 7.468  -35.130 -24.353 1.00 64.73 ? 92  ARG A NH2 1 
ATOM   492  N N   . PHE A 1 66  ? 11.600 -30.013 -19.059 1.00 26.64 ? 93  PHE A N   1 
ATOM   493  C CA  . PHE A 1 66  ? 11.619 -28.844 -18.204 1.00 27.10 ? 93  PHE A CA  1 
ATOM   494  C C   . PHE A 1 66  ? 10.178 -28.380 -18.040 1.00 26.90 ? 93  PHE A C   1 
ATOM   495  O O   . PHE A 1 66  ? 9.606  -27.907 -19.002 1.00 28.01 ? 93  PHE A O   1 
ATOM   496  C CB  . PHE A 1 66  ? 12.488 -27.796 -18.895 1.00 28.03 ? 93  PHE A CB  1 
ATOM   497  C CG  . PHE A 1 66  ? 13.930 -28.216 -19.108 1.00 28.83 ? 93  PHE A CG  1 
ATOM   498  C CD1 . PHE A 1 66  ? 14.689 -28.714 -18.053 1.00 28.42 ? 93  PHE A CD1 1 
ATOM   499  C CD2 . PHE A 1 66  ? 14.532 -28.094 -20.358 1.00 29.32 ? 93  PHE A CD2 1 
ATOM   500  C CE1 . PHE A 1 66  ? 16.017 -29.085 -18.250 1.00 28.57 ? 93  PHE A CE1 1 
ATOM   501  C CE2 . PHE A 1 66  ? 15.858 -28.475 -20.547 1.00 31.64 ? 93  PHE A CE2 1 
ATOM   502  C CZ  . PHE A 1 66  ? 16.596 -28.956 -19.492 1.00 29.27 ? 93  PHE A CZ  1 
ATOM   503  N N   . ARG A 1 67  ? 9.600  -28.582 -16.853 1.00 25.91 ? 94  ARG A N   1 
ATOM   504  C CA  . ARG A 1 67  ? 8.226  -28.204 -16.587 1.00 27.53 ? 94  ARG A CA  1 
ATOM   505  C C   . ARG A 1 67  ? 7.353  -28.772 -17.706 1.00 30.19 ? 94  ARG A C   1 
ATOM   506  O O   . ARG A 1 67  ? 6.442  -28.100 -18.165 1.00 32.61 ? 94  ARG A O   1 
ATOM   507  C CB  . ARG A 1 67  ? 8.093  -26.682 -16.440 1.00 25.80 ? 94  ARG A CB  1 
ATOM   508  C CG  . ARG A 1 67  ? 8.666  -26.081 -15.157 1.00 23.57 ? 94  ARG A CG  1 
ATOM   509  C CD  . ARG A 1 67  ? 7.992  -26.605 -13.898 1.00 25.31 ? 94  ARG A CD  1 
ATOM   510  N NE  . ARG A 1 67  ? 8.338  -25.801 -12.727 1.00 26.16 ? 94  ARG A NE  1 
ATOM   511  C CZ  . ARG A 1 67  ? 7.756  -25.844 -11.533 1.00 27.14 ? 94  ARG A CZ  1 
ATOM   512  N NH1 . ARG A 1 67  ? 6.742  -26.651 -11.310 1.00 31.90 ? 94  ARG A NH1 1 
ATOM   513  N NH2 . ARG A 1 67  ? 8.151  -25.024 -10.575 1.00 28.30 ? 94  ARG A NH2 1 
ATOM   514  N N   . GLY A 1 68  ? 7.662  -30.005 -18.132 1.00 31.57 ? 95  GLY A N   1 
ATOM   515  C CA  . GLY A 1 68  ? 6.854  -30.748 -19.087 1.00 34.32 ? 95  GLY A CA  1 
ATOM   516  C C   . GLY A 1 68  ? 7.173  -30.428 -20.550 1.00 32.97 ? 95  GLY A C   1 
ATOM   517  O O   . GLY A 1 68  ? 6.531  -30.993 -21.418 1.00 30.17 ? 95  GLY A O   1 
ATOM   518  N N   . PHE A 1 69  ? 8.174  -29.575 -20.809 1.00 33.09 ? 96  PHE A N   1 
ATOM   519  C CA  . PHE A 1 69  ? 8.641  -29.258 -22.153 1.00 34.24 ? 96  PHE A CA  1 
ATOM   520  C C   . PHE A 1 69  ? 9.954  -29.972 -22.483 1.00 37.79 ? 96  PHE A C   1 
ATOM   521  O O   . PHE A 1 69  ? 10.901 -29.987 -21.696 1.00 34.96 ? 96  PHE A O   1 
ATOM   522  C CB  . PHE A 1 69  ? 8.925  -27.763 -22.295 1.00 32.92 ? 96  PHE A CB  1 
ATOM   523  C CG  . PHE A 1 69  ? 7.669  -26.913 -22.254 1.00 34.71 ? 96  PHE A CG  1 
ATOM   524  C CD1 . PHE A 1 69  ? 7.131  -26.505 -21.043 1.00 32.56 ? 96  PHE A CD1 1 
ATOM   525  C CD2 . PHE A 1 69  ? 7.020  -26.552 -23.430 1.00 35.75 ? 96  PHE A CD2 1 
ATOM   526  C CE1 . PHE A 1 69  ? 5.987  -25.731 -21.006 1.00 32.41 ? 96  PHE A CE1 1 
ATOM   527  C CE2 . PHE A 1 69  ? 5.874  -25.775 -23.392 1.00 36.45 ? 96  PHE A CE2 1 
ATOM   528  C CZ  . PHE A 1 69  ? 5.348  -25.377 -22.179 1.00 36.75 ? 96  PHE A CZ  1 
ATOM   529  N N   . SER A 1 70  ? 10.019 -30.492 -23.708 1.00 39.82 ? 97  SER A N   1 
ATOM   530  C CA  . SER A 1 70  ? 11.181 -31.205 -24.215 1.00 39.13 ? 97  SER A CA  1 
ATOM   531  C C   . SER A 1 70  ? 12.229 -30.181 -24.625 1.00 35.31 ? 97  SER A C   1 
ATOM   532  O O   . SER A 1 70  ? 11.926 -28.992 -24.737 1.00 37.17 ? 97  SER A O   1 
ATOM   533  C CB  . SER A 1 70  ? 10.788 -32.062 -25.399 1.00 36.54 ? 97  SER A CB  1 
ATOM   534  O OG  . SER A 1 70  ? 10.659 -31.212 -26.536 1.00 34.09 ? 97  SER A OG  1 
ATOM   535  N N   . ILE A 1 71  ? 13.455 -30.635 -24.892 1.00 33.18 ? 98  ILE A N   1 
ATOM   536  C CA  . ILE A 1 71  ? 14.460 -29.703 -25.375 1.00 32.76 ? 98  ILE A CA  1 
ATOM   537  C C   . ILE A 1 71  ? 14.079 -29.231 -26.784 1.00 31.01 ? 98  ILE A C   1 
ATOM   538  O O   . ILE A 1 71  ? 14.265 -28.063 -27.108 1.00 28.74 ? 98  ILE A O   1 
ATOM   539  C CB  . ILE A 1 71  ? 15.883 -30.291 -25.280 1.00 33.07 ? 98  ILE A CB  1 
ATOM   540  C CG1 . ILE A 1 71  ? 16.376 -30.297 -23.807 1.00 36.17 ? 98  ILE A CG1 1 
ATOM   541  C CG2 . ILE A 1 71  ? 16.847 -29.530 -26.180 1.00 32.99 ? 98  ILE A CG2 1 
ATOM   542  C CD1 . ILE A 1 71  ? 17.642 -31.101 -23.534 1.00 34.20 ? 98  ILE A CD1 1 
ATOM   543  N N   . PRO A 1 72  ? 13.607 -30.089 -27.713 1.00 29.57 ? 99  PRO A N   1 
ATOM   544  C CA  . PRO A 1 72  ? 13.088 -29.574 -28.988 1.00 31.72 ? 99  PRO A CA  1 
ATOM   545  C C   . PRO A 1 72  ? 12.006 -28.507 -28.814 1.00 33.47 ? 99  PRO A C   1 
ATOM   546  O O   . PRO A 1 72  ? 12.075 -27.421 -29.397 1.00 36.69 ? 99  PRO A O   1 
ATOM   547  C CB  . PRO A 1 72  ? 12.583 -30.831 -29.699 1.00 30.79 ? 99  PRO A CB  1 
ATOM   548  C CG  . PRO A 1 72  ? 13.462 -31.945 -29.122 1.00 31.05 ? 99  PRO A CG  1 
ATOM   549  C CD  . PRO A 1 72  ? 13.676 -31.557 -27.664 1.00 29.46 ? 99  PRO A CD  1 
ATOM   550  N N   . GLU A 1 73  ? 11.032 -28.774 -27.949 1.00 36.07 ? 100 GLU A N   1 
ATOM   551  C CA  . GLU A 1 73  ? 10.032 -27.757 -27.693 1.00 41.89 ? 100 GLU A CA  1 
ATOM   552  C C   . GLU A 1 73  ? 10.727 -26.488 -27.203 1.00 45.37 ? 100 GLU A C   1 
ATOM   553  O O   . GLU A 1 73  ? 10.379 -25.393 -27.639 1.00 46.19 ? 100 GLU A O   1 
ATOM   554  C CB  . GLU A 1 73  ? 8.968  -28.316 -26.754 1.00 44.66 ? 100 GLU A CB  1 
ATOM   555  C CG  . GLU A 1 73  ? 8.061  -29.315 -27.464 1.00 46.98 ? 100 GLU A CG  1 
ATOM   556  C CD  . GLU A 1 73  ? 7.377  -30.302 -26.544 1.00 47.70 ? 100 GLU A CD  1 
ATOM   557  O OE1 . GLU A 1 73  ? 7.559  -30.222 -25.311 1.00 40.86 ? 100 GLU A OE1 1 
ATOM   558  O OE2 . GLU A 1 73  ? 6.652  -31.158 -27.085 1.00 52.93 ? 100 GLU A OE2 1 
ATOM   559  N N   . CYS A 1 74  ? 11.728 -26.644 -26.319 1.00 40.94 ? 101 CYS A N   1 
ATOM   560  C CA  . CYS A 1 74  ? 12.401 -25.493 -25.738 1.00 36.40 ? 101 CYS A CA  1 
ATOM   561  C C   . CYS A 1 74  ? 13.166 -24.722 -26.800 1.00 36.02 ? 101 CYS A C   1 
ATOM   562  O O   . CYS A 1 74  ? 13.132 -23.497 -26.789 1.00 32.62 ? 101 CYS A O   1 
ATOM   563  C CB  . CYS A 1 74  ? 13.308 -25.877 -24.577 1.00 34.04 ? 101 CYS A CB  1 
ATOM   564  S SG  . CYS A 1 74  ? 12.363 -26.171 -23.066 1.00 33.69 ? 101 CYS A SG  1 
ATOM   565  N N   . GLN A 1 75  ? 13.807 -25.458 -27.717 1.00 37.10 ? 102 GLN A N   1 
ATOM   566  C CA  . GLN A 1 75  ? 14.540 -24.871 -28.829 1.00 41.51 ? 102 GLN A CA  1 
ATOM   567  C C   . GLN A 1 75  ? 13.622 -23.969 -29.654 1.00 42.93 ? 102 GLN A C   1 
ATOM   568  O O   . GLN A 1 75  ? 14.034 -22.884 -30.055 1.00 47.56 ? 102 GLN A O   1 
ATOM   569  C CB  . GLN A 1 75  ? 15.178 -25.960 -29.692 1.00 42.47 ? 102 GLN A CB  1 
ATOM   570  C CG  . GLN A 1 75  ? 16.292 -26.721 -28.976 1.00 43.94 ? 102 GLN A CG  1 
ATOM   571  C CD  . GLN A 1 75  ? 17.087 -27.640 -29.878 1.00 44.29 ? 102 GLN A CD  1 
ATOM   572  O OE1 . GLN A 1 75  ? 16.690 -28.772 -30.193 1.00 40.39 ? 102 GLN A OE1 1 
ATOM   573  N NE2 . GLN A 1 75  ? 18.260 -27.157 -30.269 1.00 48.26 ? 102 GLN A NE2 1 
ATOM   574  N N   . LYS A 1 76  ? 12.378 -24.409 -29.873 1.00 45.36 ? 103 LYS A N   1 
ATOM   575  C CA  . LYS A 1 76  ? 11.428 -23.678 -30.706 1.00 51.16 ? 103 LYS A CA  1 
ATOM   576  C C   . LYS A 1 76  ? 10.753 -22.520 -29.959 1.00 47.53 ? 103 LYS A C   1 
ATOM   577  O O   . LYS A 1 76  ? 10.568 -21.444 -30.526 1.00 46.04 ? 103 LYS A O   1 
ATOM   578  C CB  . LYS A 1 76  ? 10.417 -24.691 -31.255 1.00 55.90 ? 103 LYS A CB  1 
ATOM   579  C CG  . LYS A 1 76  ? 11.024 -25.764 -32.171 1.00 63.37 ? 103 LYS A CG  1 
ATOM   580  C CD  . LYS A 1 76  ? 11.572 -25.257 -33.504 1.00 67.55 ? 103 LYS A CD  1 
ATOM   581  C CE  . LYS A 1 76  ? 10.478 -24.802 -34.429 1.00 70.83 ? 103 LYS A CE  1 
ATOM   582  N NZ  . LYS A 1 76  ? 10.983 -24.249 -35.689 1.00 73.98 ? 103 LYS A NZ  1 
ATOM   583  N N   . LEU A 1 77  ? 10.388 -22.728 -28.687 1.00 45.35 ? 104 LEU A N   1 
ATOM   584  C CA  . LEU A 1 77  ? 9.509  -21.809 -27.975 1.00 39.21 ? 104 LEU A CA  1 
ATOM   585  C C   . LEU A 1 77  ? 10.293 -20.738 -27.223 1.00 36.92 ? 104 LEU A C   1 
ATOM   586  O O   . LEU A 1 77  ? 9.798  -19.632 -27.096 1.00 34.98 ? 104 LEU A O   1 
ATOM   587  C CB  . LEU A 1 77  ? 8.632  -22.570 -26.989 1.00 42.90 ? 104 LEU A CB  1 
ATOM   588  C CG  . LEU A 1 77  ? 7.553  -23.490 -27.566 1.00 49.03 ? 104 LEU A CG  1 
ATOM   589  C CD1 . LEU A 1 77  ? 6.943  -24.346 -26.455 1.00 45.20 ? 104 LEU A CD1 1 
ATOM   590  C CD2 . LEU A 1 77  ? 6.473  -22.689 -28.278 1.00 52.56 ? 104 LEU A CD2 1 
ATOM   591  N N   . LEU A 1 78  ? 11.470 -21.076 -26.665 1.00 35.67 ? 105 LEU A N   1 
ATOM   592  C CA  . LEU A 1 78  ? 12.158 -20.188 -25.736 1.00 31.67 ? 105 LEU A CA  1 
ATOM   593  C C   . LEU A 1 78  ? 12.747 -19.026 -26.514 1.00 29.57 ? 105 LEU A C   1 
ATOM   594  O O   . LEU A 1 78  ? 13.280 -19.235 -27.598 1.00 31.36 ? 105 LEU A O   1 
ATOM   595  C CB  . LEU A 1 78  ? 13.262 -20.883 -24.943 1.00 32.75 ? 105 LEU A CB  1 
ATOM   596  C CG  . LEU A 1 78  ? 12.811 -21.785 -23.790 1.00 32.73 ? 105 LEU A CG  1 
ATOM   597  C CD1 . LEU A 1 78  ? 14.030 -22.484 -23.206 1.00 32.74 ? 105 LEU A CD1 1 
ATOM   598  C CD2 . LEU A 1 78  ? 12.069 -20.997 -22.711 1.00 32.09 ? 105 LEU A CD2 1 
ATOM   599  N N   . PRO A 1 79  ? 12.690 -17.782 -25.987 1.00 28.90 ? 106 PRO A N   1 
ATOM   600  C CA  . PRO A 1 79  ? 13.313 -16.651 -26.664 1.00 32.47 ? 106 PRO A CA  1 
ATOM   601  C C   . PRO A 1 79  ? 14.800 -16.884 -26.933 1.00 39.14 ? 106 PRO A C   1 
ATOM   602  O O   . PRO A 1 79  ? 15.521 -17.431 -26.100 1.00 34.38 ? 106 PRO A O   1 
ATOM   603  C CB  . PRO A 1 79  ? 13.070 -15.466 -25.716 1.00 30.59 ? 106 PRO A CB  1 
ATOM   604  C CG  . PRO A 1 79  ? 11.813 -15.853 -24.989 1.00 30.42 ? 106 PRO A CG  1 
ATOM   605  C CD  . PRO A 1 79  ? 11.917 -17.370 -24.807 1.00 28.53 ? 106 PRO A CD  1 
ATOM   606  N N   . LYS A 1 80  ? 15.228 -16.419 -28.108 1.00 40.56 ? 107 LYS A N   1 
ATOM   607  C CA  . LYS A 1 80  ? 16.608 -16.448 -28.533 1.00 40.73 ? 107 LYS A CA  1 
ATOM   608  C C   . LYS A 1 80  ? 17.120 -15.021 -28.467 1.00 35.74 ? 107 LYS A C   1 
ATOM   609  O O   . LYS A 1 80  ? 16.328 -14.099 -28.343 1.00 37.92 ? 107 LYS A O   1 
ATOM   610  C CB  . LYS A 1 80  ? 16.573 -17.056 -29.936 1.00 45.97 ? 107 LYS A CB  1 
ATOM   611  C CG  . LYS A 1 80  ? 15.888 -18.414 -30.000 1.00 51.82 ? 107 LYS A CG  1 
ATOM   612  C CD  . LYS A 1 80  ? 15.509 -18.845 -31.415 1.00 59.11 ? 107 LYS A CD  1 
ATOM   613  C CE  . LYS A 1 80  ? 15.155 -20.300 -31.535 1.00 59.27 ? 107 LYS A CE  1 
ATOM   614  N NZ  . LYS A 1 80  ? 14.264 -20.751 -30.463 1.00 63.41 ? 107 LYS A NZ  1 
ATOM   615  N N   . ALA A 1 81  ? 18.440 -14.851 -28.473 1.00 38.19 ? 108 ALA A N   1 
ATOM   616  C CA  . ALA A 1 81  ? 19.039 -13.546 -28.700 1.00 43.50 ? 108 ALA A CA  1 
ATOM   617  C C   . ALA A 1 81  ? 18.704 -13.084 -30.120 1.00 46.53 ? 108 ALA A C   1 
ATOM   618  O O   . ALA A 1 81  ? 18.485 -13.916 -31.007 1.00 47.13 ? 108 ALA A O   1 
ATOM   619  C CB  . ALA A 1 81  ? 20.536 -13.619 -28.477 1.00 43.43 ? 108 ALA A CB  1 
ATOM   620  N N   . LYS A 1 82  ? 18.691 -11.762 -30.335 1.00 50.40 ? 109 LYS A N   1 
ATOM   621  C CA  . LYS A 1 82  ? 18.143 -11.197 -31.564 1.00 60.79 ? 109 LYS A CA  1 
ATOM   622  C C   . LYS A 1 82  ? 18.813 -11.831 -32.787 1.00 57.36 ? 109 LYS A C   1 
ATOM   623  O O   . LYS A 1 82  ? 18.127 -12.404 -33.636 1.00 55.58 ? 109 LYS A O   1 
ATOM   624  C CB  . LYS A 1 82  ? 18.255 -9.674  -31.698 1.00 64.89 ? 109 LYS A CB  1 
ATOM   625  C CG  . LYS A 1 82  ? 17.813 -8.825  -30.507 1.00 72.71 ? 109 LYS A CG  1 
ATOM   626  C CD  . LYS A 1 82  ? 18.929 -8.426  -29.543 1.00 78.97 ? 109 LYS A CD  1 
ATOM   627  C CE  . LYS A 1 82  ? 20.185 -7.963  -30.232 1.00 80.38 ? 109 LYS A CE  1 
ATOM   628  N NZ  . LYS A 1 82  ? 21.139 -7.346  -29.307 1.00 83.65 ? 109 LYS A NZ  1 
ATOM   629  N N   . GLY A 1 83  ? 20.151 -11.751 -32.854 1.00 48.40 ? 110 GLY A N   1 
ATOM   630  C CA  . GLY A 1 83  ? 20.891 -12.327 -33.965 1.00 48.16 ? 110 GLY A CA  1 
ATOM   631  C C   . GLY A 1 83  ? 21.229 -13.807 -33.780 1.00 45.14 ? 110 GLY A C   1 
ATOM   632  O O   . GLY A 1 83  ? 22.151 -14.296 -34.423 1.00 48.28 ? 110 GLY A O   1 
ATOM   633  N N   . GLY A 1 84  ? 20.480 -14.522 -32.930 1.00 40.91 ? 111 GLY A N   1 
ATOM   634  C CA  . GLY A 1 84  ? 20.854 -15.863 -32.519 1.00 38.82 ? 111 GLY A CA  1 
ATOM   635  C C   . GLY A 1 84  ? 19.764 -16.867 -32.868 1.00 36.13 ? 111 GLY A C   1 
ATOM   636  O O   . GLY A 1 84  ? 18.664 -16.491 -33.252 1.00 38.75 ? 111 GLY A O   1 
ATOM   637  N N   . GLU A 1 85  ? 20.101 -18.146 -32.737 1.00 35.14 ? 112 GLU A N   1 
ATOM   638  C CA  . GLU A 1 85  ? 19.182 -19.251 -32.957 1.00 39.66 ? 112 GLU A CA  1 
ATOM   639  C C   . GLU A 1 85  ? 19.043 -20.106 -31.698 1.00 39.06 ? 112 GLU A C   1 
ATOM   640  O O   . GLU A 1 85  ? 18.170 -20.971 -31.631 1.00 41.34 ? 112 GLU A O   1 
ATOM   641  C CB  . GLU A 1 85  ? 19.688 -20.105 -34.123 1.00 41.91 ? 112 GLU A CB  1 
ATOM   642  C CG  . GLU A 1 85  ? 19.756 -19.349 -35.456 1.00 51.71 ? 112 GLU A CG  1 
ATOM   643  C CD  . GLU A 1 85  ? 18.456 -18.738 -35.995 1.00 63.02 ? 112 GLU A CD  1 
ATOM   644  O OE1 . GLU A 1 85  ? 17.375 -19.331 -35.732 1.00 68.63 ? 112 GLU A OE1 1 
ATOM   645  O OE2 . GLU A 1 85  ? 18.509 -17.704 -36.722 1.00 60.83 ? 112 GLU A OE2 1 
ATOM   646  N N   . GLU A 1 86  ? 19.921 -19.899 -30.708 1.00 38.12 ? 113 GLU A N   1 
ATOM   647  C CA  . GLU A 1 86  ? 19.960 -20.803 -29.564 1.00 39.35 ? 113 GLU A CA  1 
ATOM   648  C C   . GLU A 1 86  ? 19.138 -20.213 -28.423 1.00 31.34 ? 113 GLU A C   1 
ATOM   649  O O   . GLU A 1 86  ? 19.157 -19.010 -28.183 1.00 34.41 ? 113 GLU A O   1 
ATOM   650  C CB  . GLU A 1 86  ? 21.401 -21.126 -29.157 1.00 41.05 ? 113 GLU A CB  1 
ATOM   651  C CG  . GLU A 1 86  ? 22.201 -21.794 -30.274 1.00 42.68 ? 113 GLU A CG  1 
ATOM   652  C CD  . GLU A 1 86  ? 21.633 -23.113 -30.781 1.00 43.87 ? 113 GLU A CD  1 
ATOM   653  O OE1 . GLU A 1 86  ? 20.737 -23.685 -30.137 1.00 42.47 ? 113 GLU A OE1 1 
ATOM   654  O OE2 . GLU A 1 86  ? 22.056 -23.551 -31.869 1.00 43.31 ? 113 GLU A OE2 1 
ATOM   655  N N   . PRO A 1 87  ? 18.391 -21.043 -27.672 1.00 32.44 ? 114 PRO A N   1 
ATOM   656  C CA  . PRO A 1 87  ? 17.551 -20.527 -26.591 1.00 30.98 ? 114 PRO A CA  1 
ATOM   657  C C   . PRO A 1 87  ? 18.415 -19.878 -25.515 1.00 33.05 ? 114 PRO A C   1 
ATOM   658  O O   . PRO A 1 87  ? 19.523 -20.348 -25.220 1.00 32.79 ? 114 PRO A O   1 
ATOM   659  C CB  . PRO A 1 87  ? 16.822 -21.761 -26.097 1.00 29.76 ? 114 PRO A CB  1 
ATOM   660  C CG  . PRO A 1 87  ? 17.785 -22.883 -26.412 1.00 30.94 ? 114 PRO A CG  1 
ATOM   661  C CD  . PRO A 1 87  ? 18.383 -22.515 -27.759 1.00 32.41 ? 114 PRO A CD  1 
ATOM   662  N N   . LEU A 1 88  ? 17.890 -18.791 -24.952 1.00 28.99 ? 115 LEU A N   1 
ATOM   663  C CA  . LEU A 1 88  ? 18.571 -18.078 -23.894 1.00 30.49 ? 115 LEU A CA  1 
ATOM   664  C C   . LEU A 1 88  ? 18.327 -18.814 -22.576 1.00 30.11 ? 115 LEU A C   1 
ATOM   665  O O   . LEU A 1 88  ? 17.199 -19.202 -22.274 1.00 26.60 ? 115 LEU A O   1 
ATOM   666  C CB  . LEU A 1 88  ? 18.070 -16.635 -23.867 1.00 30.47 ? 115 LEU A CB  1 
ATOM   667  C CG  . LEU A 1 88  ? 18.515 -15.731 -25.019 1.00 32.28 ? 115 LEU A CG  1 
ATOM   668  C CD1 . LEU A 1 88  ? 18.147 -14.297 -24.686 1.00 30.87 ? 115 LEU A CD1 1 
ATOM   669  C CD2 . LEU A 1 88  ? 19.998 -15.833 -25.334 1.00 33.88 ? 115 LEU A CD2 1 
ATOM   670  N N   . PRO A 1 89  ? 19.375 -19.074 -21.757 1.00 29.53 ? 116 PRO A N   1 
ATOM   671  C CA  . PRO A 1 89  ? 19.174 -19.694 -20.443 1.00 26.44 ? 116 PRO A CA  1 
ATOM   672  C C   . PRO A 1 89  ? 18.264 -18.934 -19.479 1.00 22.76 ? 116 PRO A C   1 
ATOM   673  O O   . PRO A 1 89  ? 17.612 -19.555 -18.642 1.00 24.36 ? 116 PRO A O   1 
ATOM   674  C CB  . PRO A 1 89  ? 20.584 -19.923 -19.871 1.00 26.35 ? 116 PRO A CB  1 
ATOM   675  C CG  . PRO A 1 89  ? 21.535 -19.338 -20.865 1.00 26.78 ? 116 PRO A CG  1 
ATOM   676  C CD  . PRO A 1 89  ? 20.790 -18.899 -22.103 1.00 27.50 ? 116 PRO A CD  1 
ATOM   677  N N   . GLU A 1 90  ? 18.215 -17.613 -19.611 1.00 23.09 ? 117 GLU A N   1 
ATOM   678  C CA  . GLU A 1 90  ? 17.242 -16.772 -18.931 1.00 24.86 ? 117 GLU A CA  1 
ATOM   679  C C   . GLU A 1 90  ? 15.824 -17.333 -19.041 1.00 25.62 ? 117 GLU A C   1 
ATOM   680  O O   . GLU A 1 90  ? 15.117 -17.490 -18.043 1.00 24.37 ? 117 GLU A O   1 
ATOM   681  C CB  . GLU A 1 90  ? 17.210 -15.360 -19.518 1.00 26.09 ? 117 GLU A CB  1 
ATOM   682  C CG  . GLU A 1 90  ? 18.353 -14.447 -19.097 1.00 25.62 ? 117 GLU A CG  1 
ATOM   683  C CD  . GLU A 1 90  ? 19.559 -14.361 -20.015 1.00 26.60 ? 117 GLU A CD  1 
ATOM   684  O OE1 . GLU A 1 90  ? 19.908 -15.406 -20.616 1.00 24.96 ? 117 GLU A OE1 1 
ATOM   685  O OE2 . GLU A 1 90  ? 20.190 -13.252 -20.064 1.00 26.08 ? 117 GLU A OE2 1 
ATOM   686  N N   . GLY A 1 91  ? 15.400 -17.626 -20.266 1.00 22.02 ? 118 GLY A N   1 
ATOM   687  C CA  . GLY A 1 91  ? 14.056 -18.095 -20.463 1.00 24.60 ? 118 GLY A CA  1 
ATOM   688  C C   . GLY A 1 91  ? 13.848 -19.476 -19.854 1.00 24.20 ? 118 GLY A C   1 
ATOM   689  O O   . GLY A 1 91  ? 12.759 -19.786 -19.383 1.00 25.63 ? 118 GLY A O   1 
ATOM   690  N N   . LEU A 1 92  ? 14.874 -20.322 -19.922 1.00 23.55 ? 119 LEU A N   1 
ATOM   691  C CA  . LEU A 1 92  ? 14.785 -21.605 -19.262 1.00 23.43 ? 119 LEU A CA  1 
ATOM   692  C C   . LEU A 1 92  ? 14.532 -21.399 -17.769 1.00 22.31 ? 119 LEU A C   1 
ATOM   693  O O   . LEU A 1 92  ? 13.665 -22.049 -17.190 1.00 22.03 ? 119 LEU A O   1 
ATOM   694  C CB  . LEU A 1 92  ? 16.002 -22.491 -19.440 1.00 30.14 ? 119 LEU A CB  1 
ATOM   695  C CG  . LEU A 1 92  ? 15.898 -23.684 -18.496 1.00 31.98 ? 119 LEU A CG  1 
ATOM   696  C CD1 . LEU A 1 92  ? 15.596 -24.956 -19.211 1.00 32.70 ? 119 LEU A CD1 1 
ATOM   697  C CD2 . LEU A 1 92  ? 17.086 -23.696 -17.567 1.00 33.77 ? 119 LEU A CD2 1 
ATOM   698  N N   . PHE A 1 93  ? 15.291 -20.510 -17.129 1.00 22.44 ? 120 PHE A N   1 
ATOM   699  C CA  . PHE A 1 93  ? 15.108 -20.278 -15.705 1.00 22.08 ? 120 PHE A CA  1 
ATOM   700  C C   . PHE A 1 93  ? 13.678 -19.791 -15.428 1.00 22.78 ? 120 PHE A C   1 
ATOM   701  O O   . PHE A 1 93  ? 13.058 -20.171 -14.438 1.00 20.02 ? 120 PHE A O   1 
ATOM   702  C CB  . PHE A 1 93  ? 16.144 -19.262 -15.219 1.00 20.15 ? 120 PHE A CB  1 
ATOM   703  C CG  . PHE A 1 93  ? 15.969 -18.924 -13.750 1.00 19.50 ? 120 PHE A CG  1 
ATOM   704  C CD1 . PHE A 1 93  ? 16.407 -19.794 -12.765 1.00 18.39 ? 120 PHE A CD1 1 
ATOM   705  C CD2 . PHE A 1 93  ? 15.345 -17.750 -13.348 1.00 20.19 ? 120 PHE A CD2 1 
ATOM   706  C CE1 . PHE A 1 93  ? 16.253 -19.499 -11.424 1.00 17.84 ? 120 PHE A CE1 1 
ATOM   707  C CE2 . PHE A 1 93  ? 15.195 -17.466 -12.001 1.00 20.54 ? 120 PHE A CE2 1 
ATOM   708  C CZ  . PHE A 1 93  ? 15.668 -18.334 -11.041 1.00 18.34 ? 120 PHE A CZ  1 
ATOM   709  N N   . TRP A 1 94  ? 13.169 -18.932 -16.304 1.00 22.55 ? 121 TRP A N   1 
ATOM   710  C CA  . TRP A 1 94  ? 11.809 -18.421 -16.174 1.00 25.69 ? 121 TRP A CA  1 
ATOM   711  C C   . TRP A 1 94  ? 10.831 -19.590 -16.251 1.00 25.97 ? 121 TRP A C   1 
ATOM   712  O O   . TRP A 1 94  ? 9.950  -19.732 -15.418 1.00 28.24 ? 121 TRP A O   1 
ATOM   713  C CB  . TRP A 1 94  ? 11.515 -17.377 -17.255 1.00 24.37 ? 121 TRP A CB  1 
ATOM   714  C CG  . TRP A 1 94  ? 10.200 -16.678 -17.045 1.00 24.50 ? 121 TRP A CG  1 
ATOM   715  C CD1 . TRP A 1 94  ? 8.952  -17.196 -17.224 1.00 23.79 ? 121 TRP A CD1 1 
ATOM   716  C CD2 . TRP A 1 94  ? 10.016 -15.328 -16.585 1.00 22.88 ? 121 TRP A CD2 1 
ATOM   717  N NE1 . TRP A 1 94  ? 8.001  -16.258 -16.942 1.00 26.19 ? 121 TRP A NE1 1 
ATOM   718  C CE2 . TRP A 1 94  ? 8.622  -15.107 -16.526 1.00 24.79 ? 121 TRP A CE2 1 
ATOM   719  C CE3 . TRP A 1 94  ? 10.887 -14.295 -16.234 1.00 23.67 ? 121 TRP A CE3 1 
ATOM   720  C CZ2 . TRP A 1 94  ? 8.084  -13.896 -16.106 1.00 23.80 ? 121 TRP A CZ2 1 
ATOM   721  C CZ3 . TRP A 1 94  ? 10.352 -13.100 -15.800 1.00 25.20 ? 121 TRP A CZ3 1 
ATOM   722  C CH2 . TRP A 1 94  ? 8.970  -12.904 -15.737 1.00 24.44 ? 121 TRP A CH2 1 
ATOM   723  N N   . LEU A 1 95  ? 11.007 -20.469 -17.230 1.00 26.02 ? 122 LEU A N   1 
ATOM   724  C CA  . LEU A 1 95  ? 10.172 -21.655 -17.309 1.00 24.07 ? 122 LEU A CA  1 
ATOM   725  C C   . LEU A 1 95  ? 10.206 -22.489 -16.025 1.00 25.65 ? 122 LEU A C   1 
ATOM   726  O O   . LEU A 1 95  ? 9.166  -22.899 -15.494 1.00 24.79 ? 122 LEU A O   1 
ATOM   727  C CB  . LEU A 1 95  ? 10.630 -22.460 -18.515 1.00 25.28 ? 122 LEU A CB  1 
ATOM   728  C CG  . LEU A 1 95  ? 9.968  -23.816 -18.723 1.00 26.88 ? 122 LEU A CG  1 
ATOM   729  C CD1 . LEU A 1 95  ? 8.444  -23.723 -18.807 1.00 30.20 ? 122 LEU A CD1 1 
ATOM   730  C CD2 . LEU A 1 95  ? 10.544 -24.402 -19.985 1.00 29.25 ? 122 LEU A CD2 1 
ATOM   731  N N   . LEU A 1 96  ? 11.395 -22.764 -15.503 1.00 24.02 ? 123 LEU A N   1 
ATOM   732  C CA  . LEU A 1 96  ? 11.508 -23.665 -14.367 1.00 22.75 ? 123 LEU A CA  1 
ATOM   733  C C   . LEU A 1 96  ? 10.805 -23.052 -13.158 1.00 23.95 ? 123 LEU A C   1 
ATOM   734  O O   . LEU A 1 96  ? 10.173 -23.768 -12.376 1.00 23.43 ? 123 LEU A O   1 
ATOM   735  C CB  . LEU A 1 96  ? 12.982 -23.964 -14.092 1.00 24.48 ? 123 LEU A CB  1 
ATOM   736  C CG  . LEU A 1 96  ? 13.764 -24.703 -15.191 1.00 24.08 ? 123 LEU A CG  1 
ATOM   737  C CD1 . LEU A 1 96  ? 15.173 -25.083 -14.740 1.00 26.68 ? 123 LEU A CD1 1 
ATOM   738  C CD2 . LEU A 1 96  ? 13.096 -25.975 -15.602 1.00 24.52 ? 123 LEU A CD2 1 
ATOM   739  N N   . VAL A 1 97  ? 10.899 -21.720 -13.034 1.00 23.63 ? 124 VAL A N   1 
ATOM   740  C CA  . VAL A 1 97  ? 10.358 -20.986 -11.901 1.00 26.25 ? 124 VAL A CA  1 
ATOM   741  C C   . VAL A 1 97  ? 8.843  -20.844 -12.023 1.00 26.61 ? 124 VAL A C   1 
ATOM   742  O O   . VAL A 1 97  ? 8.152  -20.945 -11.017 1.00 28.31 ? 124 VAL A O   1 
ATOM   743  C CB  . VAL A 1 97  ? 11.035 -19.609 -11.768 1.00 26.31 ? 124 VAL A CB  1 
ATOM   744  C CG1 . VAL A 1 97  ? 10.269 -18.670 -10.849 1.00 28.13 ? 124 VAL A CG1 1 
ATOM   745  C CG2 . VAL A 1 97  ? 12.481 -19.765 -11.298 1.00 26.42 ? 124 VAL A CG2 1 
ATOM   746  N N   . THR A 1 98  ? 8.321  -20.596 -13.230 1.00 27.71 ? 125 THR A N   1 
ATOM   747  C CA  . THR A 1 98  ? 6.915  -20.217 -13.367 1.00 28.68 ? 125 THR A CA  1 
ATOM   748  C C   . THR A 1 98  ? 6.055  -21.358 -13.935 1.00 31.60 ? 125 THR A C   1 
ATOM   749  O O   . THR A 1 98  ? 4.828  -21.316 -13.814 1.00 29.69 ? 125 THR A O   1 
ATOM   750  C CB  . THR A 1 98  ? 6.790  -18.962 -14.227 1.00 26.02 ? 125 THR A CB  1 
ATOM   751  O OG1 . THR A 1 98  ? 7.224  -19.290 -15.543 1.00 29.09 ? 125 THR A OG1 1 
ATOM   752  C CG2 . THR A 1 98  ? 7.596  -17.801 -13.680 1.00 27.68 ? 125 THR A CG2 1 
ATOM   753  N N   . GLY A 1 99  ? 6.680  -22.354 -14.571 1.00 30.53 ? 126 GLY A N   1 
ATOM   754  C CA  . GLY A 1 99  ? 5.963  -23.337 -15.364 1.00 30.29 ? 126 GLY A CA  1 
ATOM   755  C C   . GLY A 1 99  ? 5.515  -22.809 -16.734 1.00 28.96 ? 126 GLY A C   1 
ATOM   756  O O   . GLY A 1 99  ? 4.891  -23.541 -17.491 1.00 28.04 ? 126 GLY A O   1 
ATOM   757  N N   . HIS A 1 100 ? 5.862  -21.565 -17.073 1.00 31.77 ? 127 HIS A N   1 
ATOM   758  C CA  . HIS A 1 100 ? 5.383  -20.921 -18.282 1.00 33.24 ? 127 HIS A CA  1 
ATOM   759  C C   . HIS A 1 100 ? 6.560  -20.488 -19.151 1.00 32.37 ? 127 HIS A C   1 
ATOM   760  O O   . HIS A 1 100 ? 7.599  -20.052 -18.650 1.00 29.36 ? 127 HIS A O   1 
ATOM   761  C CB  . HIS A 1 100 ? 4.615  -19.630 -17.964 1.00 39.89 ? 127 HIS A CB  1 
ATOM   762  C CG  . HIS A 1 100 ? 3.447  -19.768 -17.041 1.00 44.42 ? 127 HIS A CG  1 
ATOM   763  N ND1 . HIS A 1 100 ? 2.266  -20.385 -17.394 1.00 49.57 ? 127 HIS A ND1 1 
ATOM   764  C CD2 . HIS A 1 100 ? 3.273  -19.338 -15.783 1.00 51.15 ? 127 HIS A CD2 1 
ATOM   765  C CE1 . HIS A 1 100 ? 1.417  -20.333 -16.374 1.00 51.13 ? 127 HIS A CE1 1 
ATOM   766  N NE2 . HIS A 1 100 ? 2.008  -19.704 -15.380 1.00 53.44 ? 127 HIS A NE2 1 
ATOM   767  N N   . ILE A 1 101 ? 6.360  -20.588 -20.466 1.00 29.18 ? 128 ILE A N   1 
ATOM   768  C CA  . ILE A 1 101 ? 7.253  -20.017 -21.463 1.00 29.55 ? 128 ILE A CA  1 
ATOM   769  C C   . ILE A 1 101 ? 7.190  -18.498 -21.321 1.00 27.26 ? 128 ILE A C   1 
ATOM   770  O O   . ILE A 1 101 ? 6.110  -17.925 -21.301 1.00 27.26 ? 128 ILE A O   1 
ATOM   771  C CB  . ILE A 1 101 ? 6.819  -20.511 -22.861 1.00 33.68 ? 128 ILE A CB  1 
ATOM   772  C CG1 . ILE A 1 101 ? 6.900  -22.035 -22.969 1.00 41.20 ? 128 ILE A CG1 1 
ATOM   773  C CG2 . ILE A 1 101 ? 7.597  -19.841 -23.986 1.00 35.61 ? 128 ILE A CG2 1 
ATOM   774  C CD1 . ILE A 1 101 ? 8.290  -22.610 -22.746 1.00 43.55 ? 128 ILE A CD1 1 
ATOM   775  N N   . PRO A 1 102 ? 8.323  -17.788 -21.157 1.00 25.35 ? 129 PRO A N   1 
ATOM   776  C CA  . PRO A 1 102 ? 8.287  -16.343 -20.993 1.00 27.46 ? 129 PRO A CA  1 
ATOM   777  C C   . PRO A 1 102 ? 8.059  -15.632 -22.315 1.00 31.77 ? 129 PRO A C   1 
ATOM   778  O O   . PRO A 1 102 ? 8.332  -16.191 -23.364 1.00 30.27 ? 129 PRO A O   1 
ATOM   779  C CB  . PRO A 1 102 ? 9.692  -16.043 -20.471 1.00 27.09 ? 129 PRO A CB  1 
ATOM   780  C CG  . PRO A 1 102 ? 10.537 -17.047 -21.199 1.00 26.85 ? 129 PRO A CG  1 
ATOM   781  C CD  . PRO A 1 102 ? 9.693  -18.318 -21.147 1.00 26.37 ? 129 PRO A CD  1 
ATOM   782  N N   . THR A 1 103 ? 7.653  -14.362 -22.242 1.00 35.93 ? 130 THR A N   1 
ATOM   783  C CA  . THR A 1 103 ? 7.712  -13.500 -23.408 1.00 35.21 ? 130 THR A CA  1 
ATOM   784  C C   . THR A 1 103 ? 9.164  -13.076 -23.622 1.00 39.96 ? 130 THR A C   1 
ATOM   785  O O   . THR A 1 103 ? 9.998  -13.230 -22.737 1.00 34.75 ? 130 THR A O   1 
ATOM   786  C CB  . THR A 1 103 ? 6.821  -12.276 -23.223 1.00 34.02 ? 130 THR A CB  1 
ATOM   787  O OG1 . THR A 1 103 ? 7.351  -11.619 -22.077 1.00 31.24 ? 130 THR A OG1 1 
ATOM   788  C CG2 . THR A 1 103 ? 5.352  -12.609 -23.029 1.00 36.48 ? 130 THR A CG2 1 
ATOM   789  N N   . GLU A 1 104 ? 9.426  -12.493 -24.798 1.00 41.40 ? 131 GLU A N   1 
ATOM   790  C CA  . GLU A 1 104 ? 10.670 -11.800 -25.093 1.00 42.54 ? 131 GLU A CA  1 
ATOM   791  C C   . GLU A 1 104 ? 10.961 -10.767 -24.014 1.00 35.45 ? 131 GLU A C   1 
ATOM   792  O O   . GLU A 1 104 ? 12.100 -10.621 -23.599 1.00 31.93 ? 131 GLU A O   1 
ATOM   793  C CB  . GLU A 1 104 ? 10.589 -10.986 -26.386 1.00 48.28 ? 131 GLU A CB  1 
ATOM   794  C CG  . GLU A 1 104 ? 10.270 -11.821 -27.627 1.00 54.50 ? 131 GLU A CG  1 
ATOM   795  C CD  . GLU A 1 104 ? 11.463 -12.427 -28.336 1.00 59.44 ? 131 GLU A CD  1 
ATOM   796  O OE1 . GLU A 1 104 ? 12.592 -11.901 -28.232 1.00 61.21 ? 131 GLU A OE1 1 
ATOM   797  O OE2 . GLU A 1 104 ? 11.241 -13.460 -28.988 1.00 56.45 ? 131 GLU A OE2 1 
ATOM   798  N N   . GLU A 1 105 ? 9.931  -10.015 -23.612 1.00 33.49 ? 132 GLU A N   1 
ATOM   799  C CA  . GLU A 1 105 ? 10.112 -8.900  -22.696 1.00 34.29 ? 132 GLU A CA  1 
ATOM   800  C C   . GLU A 1 105 ? 10.445 -9.429  -21.296 1.00 31.51 ? 132 GLU A C   1 
ATOM   801  O O   . GLU A 1 105 ? 11.125 -8.762  -20.528 1.00 29.78 ? 132 GLU A O   1 
ATOM   802  C CB  . GLU A 1 105 ? 8.891  -7.987  -22.578 1.00 35.16 ? 132 GLU A CB  1 
ATOM   803  C CG  . GLU A 1 105 ? 8.584  -7.201  -23.850 1.00 38.77 ? 132 GLU A CG  1 
ATOM   804  C CD  . GLU A 1 105 ? 7.873  -8.005  -24.922 1.00 40.80 ? 132 GLU A CD  1 
ATOM   805  O OE1 . GLU A 1 105 ? 7.389  -9.131  -24.663 1.00 41.02 ? 132 GLU A OE1 1 
ATOM   806  O OE2 . GLU A 1 105 ? 7.800  -7.485  -26.048 1.00 51.98 ? 132 GLU A OE2 1 
ATOM   807  N N   . GLN A 1 106 ? 9.919  -10.607 -20.959 1.00 28.32 ? 133 GLN A N   1 
ATOM   808  C CA  . GLN A 1 106 ? 10.186 -11.192 -19.664 1.00 29.79 ? 133 GLN A CA  1 
ATOM   809  C C   . GLN A 1 106 ? 11.670 -11.551 -19.611 1.00 29.36 ? 133 GLN A C   1 
ATOM   810  O O   . GLN A 1 106 ? 12.343 -11.219 -18.634 1.00 27.37 ? 133 GLN A O   1 
ATOM   811  C CB  . GLN A 1 106 ? 9.198  -12.320 -19.407 1.00 28.90 ? 133 GLN A CB  1 
ATOM   812  C CG  . GLN A 1 106 ? 7.829  -11.816 -18.977 1.00 28.27 ? 133 GLN A CG  1 
ATOM   813  C CD  . GLN A 1 106 ? 6.771  -12.890 -19.011 1.00 30.73 ? 133 GLN A CD  1 
ATOM   814  O OE1 . GLN A 1 106 ? 6.919  -13.919 -19.677 1.00 34.42 ? 133 GLN A OE1 1 
ATOM   815  N NE2 . GLN A 1 106 ? 5.671  -12.631 -18.327 1.00 32.42 ? 133 GLN A NE2 1 
ATOM   816  N N   . VAL A 1 107 ? 12.173 -12.129 -20.703 1.00 28.11 ? 134 VAL A N   1 
ATOM   817  C CA  . VAL A 1 107 ? 13.558 -12.574 -20.784 1.00 28.02 ? 134 VAL A CA  1 
ATOM   818  C C   . VAL A 1 107 ? 14.495 -11.371 -20.816 1.00 30.11 ? 134 VAL A C   1 
ATOM   819  O O   . VAL A 1 107 ? 15.507 -11.367 -20.128 1.00 32.81 ? 134 VAL A O   1 
ATOM   820  C CB  . VAL A 1 107 ? 13.685 -13.532 -21.970 1.00 27.81 ? 134 VAL A CB  1 
ATOM   821  C CG1 . VAL A 1 107 ? 15.111 -13.855 -22.381 1.00 31.80 ? 134 VAL A CG1 1 
ATOM   822  C CG2 . VAL A 1 107 ? 12.949 -14.823 -21.660 1.00 31.02 ? 134 VAL A CG2 1 
ATOM   823  N N   . SER A 1 108 ? 14.099 -10.305 -21.516 1.00 30.16 ? 135 SER A N   1 
ATOM   824  C CA  A SER A 1 108 ? 14.884 -9.084  -21.556 0.50 29.53 ? 135 SER A CA  1 
ATOM   825  C CA  B SER A 1 108 ? 14.875 -9.078  -21.558 0.50 27.95 ? 135 SER A CA  1 
ATOM   826  C C   . SER A 1 108 ? 14.979 -8.485  -20.153 1.00 27.27 ? 135 SER A C   1 
ATOM   827  O O   . SER A 1 108 ? 16.062 -8.091  -19.731 1.00 28.30 ? 135 SER A O   1 
ATOM   828  C CB  A SER A 1 108 ? 14.333 -8.091  -22.546 0.50 29.81 ? 135 SER A CB  1 
ATOM   829  C CB  B SER A 1 108 ? 14.286 -8.105  -22.549 0.50 26.47 ? 135 SER A CB  1 
ATOM   830  O OG  A SER A 1 108 ? 15.120 -6.909  -22.519 0.50 30.02 ? 135 SER A OG  1 
ATOM   831  O OG  B SER A 1 108 ? 14.314 -8.664  -23.853 0.50 23.23 ? 135 SER A OG  1 
ATOM   832  N N   . TRP A 1 109 ? 13.847 -8.451  -19.441 1.00 26.36 ? 136 TRP A N   1 
ATOM   833  C CA  . TRP A 1 109 ? 13.787 -7.997  -18.061 1.00 29.43 ? 136 TRP A CA  1 
ATOM   834  C C   . TRP A 1 109 ? 14.736 -8.824  -17.187 1.00 26.35 ? 136 TRP A C   1 
ATOM   835  O O   . TRP A 1 109 ? 15.472 -8.270  -16.393 1.00 25.92 ? 136 TRP A O   1 
ATOM   836  C CB  . TRP A 1 109 ? 12.353 -8.064  -17.515 1.00 31.14 ? 136 TRP A CB  1 
ATOM   837  C CG  . TRP A 1 109 ? 12.275 -7.721  -16.050 1.00 30.29 ? 136 TRP A CG  1 
ATOM   838  C CD1 . TRP A 1 109 ? 12.157 -6.476  -15.514 1.00 32.01 ? 136 TRP A CD1 1 
ATOM   839  C CD2 . TRP A 1 109 ? 12.358 -8.630  -14.936 1.00 29.83 ? 136 TRP A CD2 1 
ATOM   840  N NE1 . TRP A 1 109 ? 12.165 -6.542  -14.149 1.00 33.75 ? 136 TRP A NE1 1 
ATOM   841  C CE2 . TRP A 1 109 ? 12.281 -7.847  -13.761 1.00 32.51 ? 136 TRP A CE2 1 
ATOM   842  C CE3 . TRP A 1 109 ? 12.486 -10.021 -14.818 1.00 30.95 ? 136 TRP A CE3 1 
ATOM   843  C CZ2 . TRP A 1 109 ? 12.342 -8.402  -12.479 1.00 34.39 ? 136 TRP A CZ2 1 
ATOM   844  C CZ3 . TRP A 1 109 ? 12.561 -10.571 -13.551 1.00 34.71 ? 136 TRP A CZ3 1 
ATOM   845  C CH2 . TRP A 1 109 ? 12.505 -9.771  -12.401 1.00 34.08 ? 136 TRP A CH2 1 
ATOM   846  N N   . LEU A 1 110 ? 14.752 -10.143 -17.370 1.00 27.78 ? 137 LEU A N   1 
ATOM   847  C CA  . LEU A 1 110 ? 15.603 -11.004 -16.564 1.00 27.11 ? 137 LEU A CA  1 
ATOM   848  C C   . LEU A 1 110 ? 17.091 -10.783 -16.885 1.00 24.97 ? 137 LEU A C   1 
ATOM   849  O O   . LEU A 1 110 ? 17.899 -10.645 -15.977 1.00 24.30 ? 137 LEU A O   1 
ATOM   850  C CB  . LEU A 1 110 ? 15.120 -12.434 -16.779 1.00 28.94 ? 137 LEU A CB  1 
ATOM   851  C CG  . LEU A 1 110 ? 15.743 -13.517 -15.896 1.00 28.78 ? 137 LEU A CG  1 
ATOM   852  C CD1 . LEU A 1 110 ? 15.722 -13.176 -14.409 1.00 30.09 ? 137 LEU A CD1 1 
ATOM   853  C CD2 . LEU A 1 110 ? 14.952 -14.771 -16.141 1.00 27.56 ? 137 LEU A CD2 1 
ATOM   854  N N   . SER A 1 111 ? 17.476 -10.690 -18.164 1.00 25.83 ? 138 SER A N   1 
ATOM   855  C CA  . SER A 1 111 ? 18.863 -10.405 -18.498 1.00 24.66 ? 138 SER A CA  1 
ATOM   856  C C   . SER A 1 111 ? 19.340 -9.149  -17.778 1.00 25.87 ? 138 SER A C   1 
ATOM   857  O O   . SER A 1 111 ? 20.460 -9.119  -17.272 1.00 28.21 ? 138 SER A O   1 
ATOM   858  C CB  . SER A 1 111 ? 19.068 -10.244 -19.989 1.00 26.18 ? 138 SER A CB  1 
ATOM   859  O OG  . SER A 1 111 ? 18.554 -11.348 -20.717 1.00 22.82 ? 138 SER A OG  1 
ATOM   860  N N   . LYS A 1 112 ? 18.492 -8.105  -17.754 1.00 28.30 ? 139 LYS A N   1 
ATOM   861  C CA  . LYS A 1 112 ? 18.818 -6.844  -17.112 1.00 30.00 ? 139 LYS A CA  1 
ATOM   862  C C   . LYS A 1 112 ? 18.934 -7.004  -15.597 1.00 31.74 ? 139 LYS A C   1 
ATOM   863  O O   . LYS A 1 112 ? 19.791 -6.381  -14.981 1.00 31.77 ? 139 LYS A O   1 
ATOM   864  C CB  . LYS A 1 112 ? 17.805 -5.738  -17.427 1.00 34.42 ? 139 LYS A CB  1 
ATOM   865  C CG  . LYS A 1 112 ? 17.946 -5.117  -18.832 1.00 41.07 ? 139 LYS A CG  1 
ATOM   866  C CD  . LYS A 1 112 ? 16.787 -4.238  -19.311 1.00 46.88 ? 139 LYS A CD  1 
ATOM   867  C CE  . LYS A 1 112 ? 15.448 -4.912  -19.135 1.00 50.71 ? 139 LYS A CE  1 
ATOM   868  N NZ  . LYS A 1 112 ? 14.340 -4.436  -19.975 1.00 47.76 ? 139 LYS A NZ  1 
ATOM   869  N N   . GLU A 1 113 ? 18.048 -7.792  -14.990 1.00 27.87 ? 140 GLU A N   1 
ATOM   870  C CA  . GLU A 1 113 ? 18.118 -8.032  -13.553 1.00 30.46 ? 140 GLU A CA  1 
ATOM   871  C C   . GLU A 1 113 ? 19.461 -8.642  -13.145 1.00 28.18 ? 140 GLU A C   1 
ATOM   872  O O   . GLU A 1 113 ? 20.069 -8.214  -12.169 1.00 29.46 ? 140 GLU A O   1 
ATOM   873  C CB  . GLU A 1 113 ? 17.026 -9.000  -13.098 1.00 32.58 ? 140 GLU A CB  1 
ATOM   874  C CG  . GLU A 1 113 ? 15.736 -8.306  -12.693 1.00 37.24 ? 140 GLU A CG  1 
ATOM   875  C CD  . GLU A 1 113 ? 15.899 -7.262  -11.598 1.00 39.03 ? 140 GLU A CD  1 
ATOM   876  O OE1 . GLU A 1 113 ? 16.429 -7.577  -10.513 1.00 41.63 ? 140 GLU A OE1 1 
ATOM   877  O OE2 . GLU A 1 113 ? 15.466 -6.123  -11.840 1.00 39.55 ? 140 GLU A OE2 1 
ATOM   878  N N   . TRP A 1 114 ? 19.870 -9.681  -13.872 1.00 28.04 ? 141 TRP A N   1 
ATOM   879  C CA  . TRP A 1 114 ? 21.073 -10.411 -13.557 1.00 27.84 ? 141 TRP A CA  1 
ATOM   880  C C   . TRP A 1 114 ? 22.289 -9.536  -13.846 1.00 35.00 ? 141 TRP A C   1 
ATOM   881  O O   . TRP A 1 114 ? 23.268 -9.596  -13.119 1.00 36.56 ? 141 TRP A O   1 
ATOM   882  C CB  . TRP A 1 114 ? 21.115 -11.725 -14.339 1.00 27.20 ? 141 TRP A CB  1 
ATOM   883  C CG  . TRP A 1 114 ? 20.112 -12.746 -13.882 1.00 23.83 ? 141 TRP A CG  1 
ATOM   884  C CD1 . TRP A 1 114 ? 19.408 -12.724 -12.721 1.00 23.84 ? 141 TRP A CD1 1 
ATOM   885  C CD2 . TRP A 1 114 ? 19.787 -13.996 -14.525 1.00 24.73 ? 141 TRP A CD2 1 
ATOM   886  N NE1 . TRP A 1 114 ? 18.631 -13.833 -12.621 1.00 24.37 ? 141 TRP A NE1 1 
ATOM   887  C CE2 . TRP A 1 114 ? 18.862 -14.652 -13.694 1.00 24.23 ? 141 TRP A CE2 1 
ATOM   888  C CE3 . TRP A 1 114 ? 20.204 -14.636 -15.693 1.00 26.61 ? 141 TRP A CE3 1 
ATOM   889  C CZ2 . TRP A 1 114 ? 18.319 -15.888 -14.011 1.00 22.58 ? 141 TRP A CZ2 1 
ATOM   890  C CZ3 . TRP A 1 114 ? 19.696 -15.875 -15.992 1.00 26.20 ? 141 TRP A CZ3 1 
ATOM   891  C CH2 . TRP A 1 114 ? 18.756 -16.493 -15.162 1.00 26.24 ? 141 TRP A CH2 1 
ATOM   892  N N   . ALA A 1 115 ? 22.209 -8.698  -14.884 1.00 35.07 ? 142 ALA A N   1 
ATOM   893  C CA  . ALA A 1 115 ? 23.275 -7.751  -15.172 1.00 31.94 ? 142 ALA A CA  1 
ATOM   894  C C   . ALA A 1 115 ? 23.478 -6.776  -14.012 1.00 30.99 ? 142 ALA A C   1 
ATOM   895  O O   . ALA A 1 115 ? 24.613 -6.431  -13.724 1.00 32.28 ? 142 ALA A O   1 
ATOM   896  C CB  . ALA A 1 115 ? 23.031 -7.028  -16.494 1.00 30.16 ? 142 ALA A CB  1 
ATOM   897  N N   . LYS A 1 116 ? 22.418 -6.377  -13.303 1.00 30.49 ? 143 LYS A N   1 
ATOM   898  C CA  . LYS A 1 116 ? 22.547 -5.391  -12.231 1.00 33.20 ? 143 LYS A CA  1 
ATOM   899  C C   . LYS A 1 116 ? 22.971 -5.989  -10.886 1.00 28.83 ? 143 LYS A C   1 
ATOM   900  O O   . LYS A 1 116 ? 23.403 -5.266  -10.000 1.00 29.25 ? 143 LYS A O   1 
ATOM   901  C CB  . LYS A 1 116 ? 21.219 -4.676  -11.955 1.00 40.00 ? 143 LYS A CB  1 
ATOM   902  C CG  . LYS A 1 116 ? 20.961 -3.471  -12.846 1.00 47.46 ? 143 LYS A CG  1 
ATOM   903  C CD  . LYS A 1 116 ? 19.634 -2.762  -12.594 1.00 49.80 ? 143 LYS A CD  1 
ATOM   904  C CE  . LYS A 1 116 ? 18.503 -3.733  -12.469 1.00 54.68 ? 143 LYS A CE  1 
ATOM   905  N NZ  . LYS A 1 116 ? 17.210 -3.062  -12.618 1.00 58.82 ? 143 LYS A NZ  1 
ATOM   906  N N   . ARG A 1 117 ? 22.807 -7.294  -10.701 1.00 25.33 ? 144 ARG A N   1 
ATOM   907  C CA  . ARG A 1 117 ? 23.164 -7.948  -9.454  1.00 26.63 ? 144 ARG A CA  1 
ATOM   908  C C   . ARG A 1 117 ? 24.557 -8.583  -9.454  1.00 30.00 ? 144 ARG A C   1 
ATOM   909  O O   . ARG A 1 117 ? 24.881 -9.293  -8.498  1.00 33.50 ? 144 ARG A O   1 
ATOM   910  C CB  . ARG A 1 117 ? 22.135 -9.072  -9.263  1.00 26.90 ? 144 ARG A CB  1 
ATOM   911  C CG  . ARG A 1 117 ? 20.762 -8.520  -8.916  1.00 25.42 ? 144 ARG A CG  1 
ATOM   912  C CD  . ARG A 1 117 ? 19.754 -9.611  -9.048  1.00 28.11 ? 144 ARG A CD  1 
ATOM   913  N NE  . ARG A 1 117 ? 18.426 -9.093  -8.707  1.00 27.96 ? 144 ARG A NE  1 
ATOM   914  C CZ  . ARG A 1 117 ? 17.741 -9.350  -7.593  1.00 27.88 ? 144 ARG A CZ  1 
ATOM   915  N NH1 . ARG A 1 117 ? 18.293 -10.010 -6.586  1.00 24.33 ? 144 ARG A NH1 1 
ATOM   916  N NH2 . ARG A 1 117 ? 16.483 -8.953  -7.510  1.00 27.61 ? 144 ARG A NH2 1 
ATOM   917  N N   . ALA A 1 118 ? 25.376 -8.379  -10.504 1.00 28.43 ? 145 ALA A N   1 
ATOM   918  C CA  . ALA A 1 118 ? 26.517 -9.265  -10.750 1.00 27.75 ? 145 ALA A CA  1 
ATOM   919  C C   . ALA A 1 118 ? 27.801 -8.911  -9.980  1.00 28.59 ? 145 ALA A C   1 
ATOM   920  O O   . ALA A 1 118 ? 28.788 -9.658  -10.038 1.00 31.59 ? 145 ALA A O   1 
ATOM   921  C CB  . ALA A 1 118 ? 26.786 -9.335  -12.241 1.00 26.56 ? 145 ALA A CB  1 
ATOM   922  N N   . ALA A 1 119 ? 27.836 -7.795  -9.249  1.00 27.32 ? 146 ALA A N   1 
ATOM   923  C CA  . ALA A 1 119 ? 29.098 -7.312  -8.714  1.00 27.58 ? 146 ALA A CA  1 
ATOM   924  C C   . ALA A 1 119 ? 29.601 -8.230  -7.599  1.00 25.98 ? 146 ALA A C   1 
ATOM   925  O O   . ALA A 1 119 ? 28.826 -8.670  -6.761  1.00 27.57 ? 146 ALA A O   1 
ATOM   926  C CB  . ALA A 1 119 ? 28.951 -5.875  -8.234  1.00 30.66 ? 146 ALA A CB  1 
ATOM   927  N N   . LEU A 1 120 ? 30.907 -8.531  -7.612  1.00 25.38 ? 147 LEU A N   1 
ATOM   928  C CA  . LEU A 1 120 ? 31.512 -9.381  -6.607  1.00 24.15 ? 147 LEU A CA  1 
ATOM   929  C C   . LEU A 1 120 ? 31.932 -8.510  -5.434  1.00 22.41 ? 147 LEU A C   1 
ATOM   930  O O   . LEU A 1 120 ? 32.419 -7.409  -5.635  1.00 21.69 ? 147 LEU A O   1 
ATOM   931  C CB  . LEU A 1 120 ? 32.701 -10.135 -7.199  1.00 23.69 ? 147 LEU A CB  1 
ATOM   932  C CG  . LEU A 1 120 ? 32.370 -11.037 -8.385  1.00 24.79 ? 147 LEU A CG  1 
ATOM   933  C CD1 . LEU A 1 120 ? 33.610 -11.752 -8.797  1.00 23.38 ? 147 LEU A CD1 1 
ATOM   934  C CD2 . LEU A 1 120 ? 31.250 -11.998 -8.081  1.00 26.82 ? 147 LEU A CD2 1 
ATOM   935  N N   . PRO A 1 121 ? 31.754 -8.963  -4.179  1.00 20.91 ? 148 PRO A N   1 
ATOM   936  C CA  . PRO A 1 121 ? 32.358 -8.290  -3.030  1.00 21.69 ? 148 PRO A CA  1 
ATOM   937  C C   . PRO A 1 121 ? 33.878 -8.446  -3.096  1.00 22.68 ? 148 PRO A C   1 
ATOM   938  O O   . PRO A 1 121 ? 34.401 -9.421  -3.657  1.00 22.58 ? 148 PRO A O   1 
ATOM   939  C CB  . PRO A 1 121 ? 31.752 -8.961  -1.793  1.00 22.97 ? 148 PRO A CB  1 
ATOM   940  C CG  . PRO A 1 121 ? 31.087 -10.221 -2.311  1.00 23.16 ? 148 PRO A CG  1 
ATOM   941  C CD  . PRO A 1 121 ? 30.978 -10.145 -3.808  1.00 22.70 ? 148 PRO A CD  1 
ATOM   942  N N   . SER A 1 122 ? 34.589 -7.480  -2.528  1.00 21.73 ? 149 SER A N   1 
ATOM   943  C CA  . SER A 1 122 ? 36.024 -7.413  -2.719  1.00 24.95 ? 149 SER A CA  1 
ATOM   944  C C   . SER A 1 122 ? 36.758 -8.566  -2.022  1.00 24.21 ? 149 SER A C   1 
ATOM   945  O O   . SER A 1 122 ? 37.837 -8.958  -2.458  1.00 27.85 ? 149 SER A O   1 
ATOM   946  C CB  . SER A 1 122 ? 36.526 -6.074  -2.304  1.00 30.71 ? 149 SER A CB  1 
ATOM   947  O OG  . SER A 1 122 ? 36.305 -5.873  -0.921  1.00 39.81 ? 149 SER A OG  1 
ATOM   948  N N   . HIS A 1 123 ? 36.218 -9.110  -0.923  1.00 26.10 ? 150 HIS A N   1 
ATOM   949  C CA  . HIS A 1 123 ? 36.868 -10.232 -0.252  1.00 24.89 ? 150 HIS A CA  1 
ATOM   950  C C   . HIS A 1 123 ? 36.900 -11.459 -1.166  1.00 23.36 ? 150 HIS A C   1 
ATOM   951  O O   . HIS A 1 123 ? 37.843 -12.230 -1.080  1.00 25.55 ? 150 HIS A O   1 
ATOM   952  C CB  . HIS A 1 123 ? 36.257 -10.546 1.124   1.00 25.35 ? 150 HIS A CB  1 
ATOM   953  C CG  . HIS A 1 123 ? 34.919 -11.209 1.135   1.00 23.40 ? 150 HIS A CG  1 
ATOM   954  N ND1 . HIS A 1 123 ? 33.762 -10.477 0.967   1.00 23.19 ? 150 HIS A ND1 1 
ATOM   955  C CD2 . HIS A 1 123 ? 34.528 -12.498 1.285   1.00 23.03 ? 150 HIS A CD2 1 
ATOM   956  C CE1 . HIS A 1 123 ? 32.712 -11.282 1.023   1.00 22.44 ? 150 HIS A CE1 1 
ATOM   957  N NE2 . HIS A 1 123 ? 33.143 -12.519 1.202   1.00 22.43 ? 150 HIS A NE2 1 
ATOM   958  N N   . VAL A 1 124 ? 35.918 -11.607 -2.070  1.00 21.50 ? 151 VAL A N   1 
ATOM   959  C CA  . VAL A 1 124 ? 35.861 -12.755 -2.960  1.00 22.85 ? 151 VAL A CA  1 
ATOM   960  C C   . VAL A 1 124 ? 36.799 -12.568 -4.150  1.00 21.81 ? 151 VAL A C   1 
ATOM   961  O O   . VAL A 1 124 ? 37.448 -13.512 -4.592  1.00 20.57 ? 151 VAL A O   1 
ATOM   962  C CB  . VAL A 1 124 ? 34.414 -13.065 -3.383  1.00 21.55 ? 151 VAL A CB  1 
ATOM   963  C CG1 . VAL A 1 124 ? 34.333 -14.051 -4.545  1.00 22.58 ? 151 VAL A CG1 1 
ATOM   964  C CG2 . VAL A 1 124 ? 33.615 -13.549 -2.187  1.00 22.55 ? 151 VAL A CG2 1 
ATOM   965  N N   . VAL A 1 125 ? 36.944 -11.336 -4.614  1.00 23.55 ? 152 VAL A N   1 
ATOM   966  C CA  . VAL A 1 125 ? 37.929 -11.003 -5.633  1.00 23.20 ? 152 VAL A CA  1 
ATOM   967  C C   . VAL A 1 125 ? 39.329 -11.310 -5.097  1.00 23.45 ? 152 VAL A C   1 
ATOM   968  O O   . VAL A 1 125 ? 40.147 -11.925 -5.772  1.00 21.29 ? 152 VAL A O   1 
ATOM   969  C CB  . VAL A 1 125 ? 37.761 -9.521  -6.044  1.00 26.72 ? 152 VAL A CB  1 
ATOM   970  C CG1 . VAL A 1 125 ? 38.857 -9.070  -7.015  1.00 29.62 ? 152 VAL A CG1 1 
ATOM   971  C CG2 . VAL A 1 125 ? 36.384 -9.257  -6.653  1.00 27.00 ? 152 VAL A CG2 1 
ATOM   972  N N   . THR A 1 126 ? 39.589 -10.930 -3.844  1.00 25.29 ? 153 THR A N   1 
ATOM   973  C CA  . THR A 1 126 ? 40.904 -11.094 -3.244  1.00 23.87 ? 153 THR A CA  1 
ATOM   974  C C   . THR A 1 126 ? 41.224 -12.575 -3.094  1.00 24.28 ? 153 THR A C   1 
ATOM   975  O O   . THR A 1 126 ? 42.359 -12.998 -3.369  1.00 21.50 ? 153 THR A O   1 
ATOM   976  C CB  . THR A 1 126 ? 40.903 -10.392 -1.885  1.00 27.74 ? 153 THR A CB  1 
ATOM   977  O OG1 . THR A 1 126 ? 40.584 -9.055  -2.221  1.00 26.40 ? 153 THR A OG1 1 
ATOM   978  C CG2 . THR A 1 126 ? 42.221 -10.503 -1.136  1.00 32.94 ? 153 THR A CG2 1 
ATOM   979  N N   . MET A 1 127 ? 40.231 -13.338 -2.610  1.00 21.48 ? 154 MET A N   1 
ATOM   980  C CA  . MET A 1 127 ? 40.383 -14.775 -2.392  1.00 22.92 ? 154 MET A CA  1 
ATOM   981  C C   . MET A 1 127 ? 40.754 -15.413 -3.731  1.00 22.35 ? 154 MET A C   1 
ATOM   982  O O   . MET A 1 127 ? 41.765 -16.115 -3.854  1.00 24.82 ? 154 MET A O   1 
ATOM   983  C CB  . MET A 1 127 ? 39.083 -15.369 -1.834  1.00 24.02 ? 154 MET A CB  1 
ATOM   984  C CG  . MET A 1 127 ? 39.165 -16.706 -1.116  1.00 28.18 ? 154 MET A CG  1 
ATOM   985  S SD  . MET A 1 127 ? 37.606 -17.639 -1.140  1.00 31.40 ? 154 MET A SD  1 
ATOM   986  C CE  . MET A 1 127 ? 36.472 -16.296 -1.480  1.00 26.23 ? 154 MET A CE  1 
ATOM   987  N N   . LEU A 1 128 ? 39.959 -15.109 -4.758  1.00 21.70 ? 155 LEU A N   1 
ATOM   988  C CA  . LEU A 1 128 ? 40.186 -15.663 -6.086  1.00 21.11 ? 155 LEU A CA  1 
ATOM   989  C C   . LEU A 1 128 ? 41.569 -15.291 -6.611  1.00 22.33 ? 155 LEU A C   1 
ATOM   990  O O   . LEU A 1 128 ? 42.263 -16.155 -7.124  1.00 22.49 ? 155 LEU A O   1 
ATOM   991  C CB  . LEU A 1 128 ? 39.100 -15.243 -7.060  1.00 21.96 ? 155 LEU A CB  1 
ATOM   992  C CG  . LEU A 1 128 ? 37.758 -15.948 -6.855  1.00 22.77 ? 155 LEU A CG  1 
ATOM   993  C CD1 . LEU A 1 128 ? 36.625 -15.334 -7.634  1.00 23.64 ? 155 LEU A CD1 1 
ATOM   994  C CD2 . LEU A 1 128 ? 37.898 -17.398 -7.242  1.00 25.50 ? 155 LEU A CD2 1 
ATOM   995  N N   . ASP A 1 129 ? 41.973 -14.028 -6.471  1.00 23.85 ? 156 ASP A N   1 
ATOM   996  C CA  . ASP A 1 129 ? 43.217 -13.569 -7.062  1.00 26.50 ? 156 ASP A CA  1 
ATOM   997  C C   . ASP A 1 129 ? 44.434 -14.174 -6.357  1.00 26.59 ? 156 ASP A C   1 
ATOM   998  O O   . ASP A 1 129 ? 45.480 -14.298 -6.979  1.00 28.32 ? 156 ASP A O   1 
ATOM   999  C CB  . ASP A 1 129 ? 43.249 -12.045 -7.120  1.00 27.63 ? 156 ASP A CB  1 
ATOM   1000 C CG  . ASP A 1 129 ? 42.289 -11.457 -8.144  1.00 30.04 ? 156 ASP A CG  1 
ATOM   1001 O OD1 . ASP A 1 129 ? 41.781 -12.221 -9.020  1.00 31.71 ? 156 ASP A OD1 1 
ATOM   1002 O OD2 . ASP A 1 129 ? 42.057 -10.241 -8.071  1.00 29.26 ? 156 ASP A OD2 1 
ATOM   1003 N N   . ASN A 1 130 ? 44.284 -14.566 -5.085  1.00 26.37 ? 157 ASN A N   1 
ATOM   1004 C CA  . ASN A 1 130 ? 45.342 -15.139 -4.277  1.00 26.58 ? 157 ASN A CA  1 
ATOM   1005 C C   . ASN A 1 130 ? 45.464 -16.656 -4.406  1.00 28.40 ? 157 ASN A C   1 
ATOM   1006 O O   . ASN A 1 130 ? 46.460 -17.219 -3.944  1.00 29.63 ? 157 ASN A O   1 
ATOM   1007 C CB  . ASN A 1 130 ? 45.157 -14.777 -2.810  1.00 27.90 ? 157 ASN A CB  1 
ATOM   1008 C CG  . ASN A 1 130 ? 45.446 -13.318 -2.597  1.00 31.57 ? 157 ASN A CG  1 
ATOM   1009 O OD1 . ASN A 1 130 ? 46.225 -12.740 -3.352  1.00 32.98 ? 157 ASN A OD1 1 
ATOM   1010 N ND2 . ASN A 1 130 ? 44.848 -12.707 -1.591  1.00 37.92 ? 157 ASN A ND2 1 
ATOM   1011 N N   . PHE A 1 131 ? 44.495 -17.317 -5.035  1.00 25.16 ? 158 PHE A N   1 
ATOM   1012 C CA  . PHE A 1 131 ? 44.509 -18.766 -5.082  1.00 25.34 ? 158 PHE A CA  1 
ATOM   1013 C C   . PHE A 1 131 ? 45.607 -19.242 -6.015  1.00 25.96 ? 158 PHE A C   1 
ATOM   1014 O O   . PHE A 1 131 ? 45.762 -18.696 -7.091  1.00 28.64 ? 158 PHE A O   1 
ATOM   1015 C CB  . PHE A 1 131 ? 43.217 -19.349 -5.668  1.00 24.83 ? 158 PHE A CB  1 
ATOM   1016 C CG  . PHE A 1 131 ? 42.057 -19.564 -4.709  1.00 23.54 ? 158 PHE A CG  1 
ATOM   1017 C CD1 . PHE A 1 131 ? 42.277 -19.795 -3.356  1.00 23.50 ? 158 PHE A CD1 1 
ATOM   1018 C CD2 . PHE A 1 131 ? 40.749 -19.562 -5.178  1.00 21.63 ? 158 PHE A CD2 1 
ATOM   1019 C CE1 . PHE A 1 131 ? 41.213 -20.006 -2.502  1.00 22.53 ? 158 PHE A CE1 1 
ATOM   1020 C CE2 . PHE A 1 131 ? 39.697 -19.750 -4.314  1.00 24.33 ? 158 PHE A CE2 1 
ATOM   1021 C CZ  . PHE A 1 131 ? 39.934 -19.974 -2.974  1.00 23.67 ? 158 PHE A CZ  1 
ATOM   1022 N N   . PRO A 1 132 ? 46.320 -20.341 -5.715  1.00 27.28 ? 159 PRO A N   1 
ATOM   1023 C CA  . PRO A 1 132 ? 47.377 -20.809 -6.607  1.00 28.25 ? 159 PRO A CA  1 
ATOM   1024 C C   . PRO A 1 132 ? 46.789 -21.473 -7.847  1.00 30.08 ? 159 PRO A C   1 
ATOM   1025 O O   . PRO A 1 132 ? 45.638 -21.903 -7.839  1.00 29.10 ? 159 PRO A O   1 
ATOM   1026 C CB  . PRO A 1 132 ? 48.143 -21.782 -5.717  1.00 26.48 ? 159 PRO A CB  1 
ATOM   1027 C CG  . PRO A 1 132 ? 47.047 -22.392 -4.871  1.00 27.09 ? 159 PRO A CG  1 
ATOM   1028 C CD  . PRO A 1 132 ? 46.125 -21.223 -4.557  1.00 27.64 ? 159 PRO A CD  1 
ATOM   1029 N N   . THR A 1 133 ? 47.617 -21.603 -8.890  1.00 29.15 ? 160 THR A N   1 
ATOM   1030 C CA  . THR A 1 133 ? 47.170 -22.140 -10.165 1.00 31.23 ? 160 THR A CA  1 
ATOM   1031 C C   . THR A 1 133 ? 46.913 -23.634 -10.053 1.00 30.50 ? 160 THR A C   1 
ATOM   1032 O O   . THR A 1 133 ? 46.189 -24.192 -10.863 1.00 34.63 ? 160 THR A O   1 
ATOM   1033 C CB  . THR A 1 133 ? 48.210 -21.845 -11.242 1.00 32.16 ? 160 THR A CB  1 
ATOM   1034 O OG1 . THR A 1 133 ? 49.375 -22.489 -10.730 1.00 32.73 ? 160 THR A OG1 1 
ATOM   1035 C CG2 . THR A 1 133 ? 48.435 -20.354 -11.419 1.00 34.69 ? 160 THR A CG2 1 
ATOM   1036 N N   . ASN A 1 134 ? 47.489 -24.292 -9.055  1.00 29.36 ? 161 ASN A N   1 
ATOM   1037 C CA  . ASN A 1 134 ? 47.279 -25.722 -8.898  1.00 33.94 ? 161 ASN A CA  1 
ATOM   1038 C C   . ASN A 1 134 ? 46.030 -26.022 -8.067  1.00 30.68 ? 161 ASN A C   1 
ATOM   1039 O O   . ASN A 1 134 ? 45.807 -27.181 -7.747  1.00 34.38 ? 161 ASN A O   1 
ATOM   1040 C CB  . ASN A 1 134 ? 48.483 -26.425 -8.266  1.00 35.55 ? 161 ASN A CB  1 
ATOM   1041 C CG  . ASN A 1 134 ? 48.623 -26.101 -6.798  1.00 38.83 ? 161 ASN A CG  1 
ATOM   1042 O OD1 . ASN A 1 134 ? 48.763 -26.996 -5.961  1.00 48.84 ? 161 ASN A OD1 1 
ATOM   1043 N ND2 . ASN A 1 134 ? 48.560 -24.831 -6.446  1.00 39.63 ? 161 ASN A ND2 1 
ATOM   1044 N N   . LEU A 1 135 ? 45.233 -25.009 -7.685  1.00 26.90 ? 162 LEU A N   1 
ATOM   1045 C CA  . LEU A 1 135 ? 43.945 -25.287 -7.067  1.00 24.08 ? 162 LEU A CA  1 
ATOM   1046 C C   . LEU A 1 135 ? 42.861 -25.406 -8.144  1.00 23.47 ? 162 LEU A C   1 
ATOM   1047 O O   . LEU A 1 135 ? 42.538 -24.427 -8.847  1.00 22.58 ? 162 LEU A O   1 
ATOM   1048 C CB  . LEU A 1 135 ? 43.552 -24.247 -6.015  1.00 24.53 ? 162 LEU A CB  1 
ATOM   1049 C CG  . LEU A 1 135 ? 42.201 -24.497 -5.322  1.00 24.81 ? 162 LEU A CG  1 
ATOM   1050 C CD1 . LEU A 1 135 ? 42.174 -25.884 -4.608  1.00 23.36 ? 162 LEU A CD1 1 
ATOM   1051 C CD2 . LEU A 1 135 ? 41.786 -23.406 -4.360  1.00 22.46 ? 162 LEU A CD2 1 
ATOM   1052 N N   . HIS A 1 136 ? 42.252 -26.602 -8.180  1.00 20.77 ? 163 HIS A N   1 
ATOM   1053 C CA  . HIS A 1 136 ? 41.336 -26.993 -9.230  1.00 24.96 ? 163 HIS A CA  1 
ATOM   1054 C C   . HIS A 1 136 ? 40.214 -25.964 -9.373  1.00 23.23 ? 163 HIS A C   1 
ATOM   1055 O O   . HIS A 1 136 ? 39.672 -25.481 -8.385  1.00 19.40 ? 163 HIS A O   1 
ATOM   1056 C CB  . HIS A 1 136 ? 40.762 -28.386 -8.936  1.00 29.75 ? 163 HIS A CB  1 
ATOM   1057 C CG  . HIS A 1 136 ? 39.991 -28.983 -10.054 1.00 36.91 ? 163 HIS A CG  1 
ATOM   1058 N ND1 . HIS A 1 136 ? 38.712 -28.572 -10.385 1.00 34.66 ? 163 HIS A ND1 1 
ATOM   1059 C CD2 . HIS A 1 136 ? 40.319 -29.945 -10.940 1.00 40.90 ? 163 HIS A CD2 1 
ATOM   1060 C CE1 . HIS A 1 136 ? 38.272 -29.271 -11.422 1.00 32.32 ? 163 HIS A CE1 1 
ATOM   1061 N NE2 . HIS A 1 136 ? 39.219 -30.128 -11.761 1.00 39.85 ? 163 HIS A NE2 1 
ATOM   1062 N N   . PRO A 1 137 ? 39.824 -25.613 -10.617 1.00 22.64 ? 164 PRO A N   1 
ATOM   1063 C CA  . PRO A 1 137 ? 38.780 -24.625 -10.831 1.00 24.08 ? 164 PRO A CA  1 
ATOM   1064 C C   . PRO A 1 137 ? 37.458 -24.907 -10.110 1.00 20.85 ? 164 PRO A C   1 
ATOM   1065 O O   . PRO A 1 137 ? 36.817 -23.974 -9.683  1.00 20.80 ? 164 PRO A O   1 
ATOM   1066 C CB  . PRO A 1 137 ? 38.615 -24.531 -12.369 1.00 25.95 ? 164 PRO A CB  1 
ATOM   1067 C CG  . PRO A 1 137 ? 39.543 -25.571 -12.944 1.00 25.85 ? 164 PRO A CG  1 
ATOM   1068 C CD  . PRO A 1 137 ? 40.462 -26.075 -11.860 1.00 24.04 ? 164 PRO A CD  1 
ATOM   1069 N N   . MET A 1 138 ? 37.069 -26.172 -9.946  1.00 20.06 ? 165 MET A N   1 
ATOM   1070 C CA  . MET A 1 138 ? 35.859 -26.533 -9.223  1.00 19.50 ? 165 MET A CA  1 
ATOM   1071 C C   . MET A 1 138 ? 35.996 -26.239 -7.727  1.00 19.94 ? 165 MET A C   1 
ATOM   1072 O O   . MET A 1 138 ? 35.035 -25.831 -7.092  1.00 20.25 ? 165 MET A O   1 
ATOM   1073 C CB  . MET A 1 138 ? 35.489 -28.010 -9.445  1.00 21.08 ? 165 MET A CB  1 
ATOM   1074 C CG  . MET A 1 138 ? 34.752 -28.267 -10.735 1.00 22.88 ? 165 MET A CG  1 
ATOM   1075 S SD  . MET A 1 138 ? 33.284 -27.224 -10.923 1.00 22.37 ? 165 MET A SD  1 
ATOM   1076 C CE  . MET A 1 138 ? 32.226 -28.184 -9.834  1.00 24.42 ? 165 MET A CE  1 
ATOM   1077 N N   . SER A 1 139 ? 37.194 -26.420 -7.158  1.00 20.20 ? 166 SER A N   1 
ATOM   1078 C CA  . SER A 1 139 ? 37.451 -26.039 -5.775  1.00 18.48 ? 166 SER A CA  1 
ATOM   1079 C C   . SER A 1 139 ? 37.341 -24.514 -5.619  1.00 18.82 ? 166 SER A C   1 
ATOM   1080 O O   . SER A 1 139 ? 36.737 -24.028 -4.666  1.00 16.70 ? 166 SER A O   1 
ATOM   1081 C CB  . SER A 1 139 ? 38.794 -26.531 -5.333  1.00 18.75 ? 166 SER A CB  1 
ATOM   1082 O OG  . SER A 1 139 ? 38.809 -27.953 -5.437  1.00 20.09 ? 166 SER A OG  1 
ATOM   1083 N N   . GLN A 1 140 ? 37.911 -23.782 -6.579  1.00 17.99 ? 167 GLN A N   1 
ATOM   1084 C CA  . GLN A 1 140 ? 37.930 -22.329 -6.541  1.00 18.65 ? 167 GLN A CA  1 
ATOM   1085 C C   . GLN A 1 140 ? 36.504 -21.801 -6.580  1.00 18.17 ? 167 GLN A C   1 
ATOM   1086 O O   . GLN A 1 140 ? 36.162 -20.909 -5.822  1.00 19.45 ? 167 GLN A O   1 
ATOM   1087 C CB  . GLN A 1 140 ? 38.729 -21.732 -7.687  1.00 20.33 ? 167 GLN A CB  1 
ATOM   1088 C CG  . GLN A 1 140 ? 40.198 -22.149 -7.726  1.00 20.53 ? 167 GLN A CG  1 
ATOM   1089 C CD  . GLN A 1 140 ? 41.051 -21.147 -8.469  1.00 23.20 ? 167 GLN A CD  1 
ATOM   1090 O OE1 . GLN A 1 140 ? 40.688 -19.970 -8.650  1.00 23.57 ? 167 GLN A OE1 1 
ATOM   1091 N NE2 . GLN A 1 140 ? 42.240 -21.594 -8.833  1.00 25.81 ? 167 GLN A NE2 1 
ATOM   1092 N N   . LEU A 1 141 ? 35.679 -22.393 -7.437  1.00 17.61 ? 168 LEU A N   1 
ATOM   1093 C CA  . LEU A 1 141 ? 34.274 -22.030 -7.560  1.00 18.75 ? 168 LEU A CA  1 
ATOM   1094 C C   . LEU A 1 141 ? 33.536 -22.223 -6.238  1.00 18.76 ? 168 LEU A C   1 
ATOM   1095 O O   . LEU A 1 141 ? 32.819 -21.333 -5.785  1.00 22.67 ? 168 LEU A O   1 
ATOM   1096 C CB  . LEU A 1 141 ? 33.643 -22.881 -8.668  1.00 17.03 ? 168 LEU A CB  1 
ATOM   1097 C CG  . LEU A 1 141 ? 32.141 -22.676 -8.887  1.00 18.71 ? 168 LEU A CG  1 
ATOM   1098 C CD1 . LEU A 1 141 ? 31.922 -21.256 -9.419  1.00 20.34 ? 168 LEU A CD1 1 
ATOM   1099 C CD2 . LEU A 1 141 ? 31.476 -23.688 -9.813  1.00 18.46 ? 168 LEU A CD2 1 
ATOM   1100 N N   . SER A 1 142 ? 33.589 -23.452 -5.722  1.00 19.50 ? 169 SER A N   1 
ATOM   1101 C CA  . SER A 1 142 ? 32.896 -23.826 -4.504  1.00 20.50 ? 169 SER A CA  1 
ATOM   1102 C C   . SER A 1 142 ? 33.349 -22.939 -3.349  1.00 19.55 ? 169 SER A C   1 
ATOM   1103 O O   . SER A 1 142 ? 32.513 -22.393 -2.642  1.00 19.56 ? 169 SER A O   1 
ATOM   1104 C CB  . SER A 1 142 ? 33.108 -25.297 -4.190  1.00 22.20 ? 169 SER A CB  1 
ATOM   1105 O OG  . SER A 1 142 ? 32.463 -25.610 -2.963  1.00 26.69 ? 169 SER A OG  1 
ATOM   1106 N N   . ALA A 1 143 ? 34.667 -22.783 -3.164  1.00 16.52 ? 170 ALA A N   1 
ATOM   1107 C CA  . ALA A 1 143 ? 35.153 -21.918 -2.101  1.00 17.61 ? 170 ALA A CA  1 
ATOM   1108 C C   . ALA A 1 143 ? 34.585 -20.498 -2.205  1.00 16.43 ? 170 ALA A C   1 
ATOM   1109 O O   . ALA A 1 143 ? 34.156 -19.953 -1.202  1.00 15.85 ? 170 ALA A O   1 
ATOM   1110 C CB  . ALA A 1 143 ? 36.642 -21.834 -2.106  1.00 17.64 ? 170 ALA A CB  1 
ATOM   1111 N N   . ALA A 1 144 ? 34.701 -19.875 -3.386  1.00 15.98 ? 171 ALA A N   1 
ATOM   1112 C CA  . ALA A 1 144 ? 34.219 -18.527 -3.631  1.00 16.95 ? 171 ALA A CA  1 
ATOM   1113 C C   . ALA A 1 144 ? 32.717 -18.401 -3.392  1.00 17.62 ? 171 ALA A C   1 
ATOM   1114 O O   . ALA A 1 144 ? 32.259 -17.391 -2.858  1.00 17.54 ? 171 ALA A O   1 
ATOM   1115 C CB  . ALA A 1 144 ? 34.553 -18.128 -5.047  1.00 18.66 ? 171 ALA A CB  1 
ATOM   1116 N N   . VAL A 1 145 ? 31.939 -19.402 -3.818  1.00 18.45 ? 172 VAL A N   1 
ATOM   1117 C CA  . VAL A 1 145 ? 30.500 -19.346 -3.621  1.00 19.17 ? 172 VAL A CA  1 
ATOM   1118 C C   . VAL A 1 145 ? 30.224 -19.423 -2.121  1.00 20.45 ? 172 VAL A C   1 
ATOM   1119 O O   . VAL A 1 145 ? 29.448 -18.642 -1.585  1.00 20.07 ? 172 VAL A O   1 
ATOM   1120 C CB  . VAL A 1 145 ? 29.697 -20.375 -4.434  1.00 21.45 ? 172 VAL A CB  1 
ATOM   1121 C CG1 . VAL A 1 145 ? 28.212 -20.330 -4.087  1.00 21.03 ? 172 VAL A CG1 1 
ATOM   1122 C CG2 . VAL A 1 145 ? 29.840 -20.109 -5.924  1.00 23.13 ? 172 VAL A CG2 1 
ATOM   1123 N N   . THR A 1 146 ? 30.954 -20.269 -1.403  1.00 20.20 ? 173 THR A N   1 
ATOM   1124 C CA  . THR A 1 146 ? 30.738 -20.356 0.029   1.00 19.30 ? 173 THR A CA  1 
ATOM   1125 C C   . THR A 1 146 ? 31.049 -19.002 0.683   1.00 19.82 ? 173 THR A C   1 
ATOM   1126 O O   . THR A 1 146 ? 30.262 -18.495 1.492   1.00 17.36 ? 173 THR A O   1 
ATOM   1127 C CB  . THR A 1 146 ? 31.556 -21.520 0.587   1.00 19.57 ? 173 THR A CB  1 
ATOM   1128 O OG1 . THR A 1 146 ? 30.927 -22.737 0.166   1.00 20.99 ? 173 THR A OG1 1 
ATOM   1129 C CG2 . THR A 1 146 ? 31.595 -21.480 2.106   1.00 19.46 ? 173 THR A CG2 1 
ATOM   1130 N N   . ALA A 1 147 ? 32.184 -18.393 0.306   1.00 19.44 ? 174 ALA A N   1 
ATOM   1131 C CA  . ALA A 1 147 ? 32.562 -17.094 0.848   1.00 19.84 ? 174 ALA A CA  1 
ATOM   1132 C C   . ALA A 1 147 ? 31.573 -15.987 0.490   1.00 20.88 ? 174 ALA A C   1 
ATOM   1133 O O   . ALA A 1 147 ? 31.478 -15.018 1.234   1.00 22.31 ? 174 ALA A O   1 
ATOM   1134 C CB  . ALA A 1 147 ? 33.940 -16.698 0.382   1.00 19.46 ? 174 ALA A CB  1 
ATOM   1135 N N   . LEU A 1 148 ? 30.825 -16.144 -0.614  1.00 22.43 ? 175 LEU A N   1 
ATOM   1136 C CA  . LEU A 1 148 ? 29.734 -15.242 -0.991  1.00 21.65 ? 175 LEU A CA  1 
ATOM   1137 C C   . LEU A 1 148 ? 28.565 -15.246 -0.002  1.00 22.22 ? 175 LEU A C   1 
ATOM   1138 O O   . LEU A 1 148 ? 27.662 -14.395 -0.096  1.00 19.43 ? 175 LEU A O   1 
ATOM   1139 C CB  . LEU A 1 148 ? 29.223 -15.568 -2.394  1.00 21.70 ? 175 LEU A CB  1 
ATOM   1140 C CG  . LEU A 1 148 ? 29.987 -15.001 -3.589  1.00 22.74 ? 175 LEU A CG  1 
ATOM   1141 C CD1 . LEU A 1 148 ? 29.403 -15.555 -4.899  1.00 21.90 ? 175 LEU A CD1 1 
ATOM   1142 C CD2 . LEU A 1 148 ? 29.927 -13.505 -3.628  1.00 23.34 ? 175 LEU A CD2 1 
ATOM   1143 N N   . ASN A 1 149 ? 28.533 -16.189 0.949   1.00 22.68 ? 176 ASN A N   1 
ATOM   1144 C CA  . ASN A 1 149 ? 27.359 -16.330 1.807   1.00 21.89 ? 176 ASN A CA  1 
ATOM   1145 C C   . ASN A 1 149 ? 27.248 -15.103 2.718   1.00 22.05 ? 176 ASN A C   1 
ATOM   1146 O O   . ASN A 1 149 ? 26.170 -14.805 3.204   1.00 22.39 ? 176 ASN A O   1 
ATOM   1147 C CB  . ASN A 1 149 ? 27.284 -17.699 2.480   1.00 22.23 ? 176 ASN A CB  1 
ATOM   1148 C CG  . ASN A 1 149 ? 27.382 -17.623 3.979   1.00 22.80 ? 176 ASN A CG  1 
ATOM   1149 O OD1 . ASN A 1 149 ? 28.402 -17.184 4.520   1.00 26.39 ? 176 ASN A OD1 1 
ATOM   1150 N ND2 . ASN A 1 149 ? 26.320 -18.015 4.654   1.00 21.40 ? 176 ASN A ND2 1 
ATOM   1151 N N   . SER A 1 150 ? 28.344 -14.360 2.849   1.00 21.82 ? 177 SER A N   1 
ATOM   1152 C CA  . SER A 1 150 ? 28.380 -13.071 3.505   1.00 24.29 ? 177 SER A CA  1 
ATOM   1153 C C   . SER A 1 150 ? 27.276 -12.180 2.971   1.00 24.94 ? 177 SER A C   1 
ATOM   1154 O O   . SER A 1 150 ? 26.742 -11.401 3.728   1.00 23.88 ? 177 SER A O   1 
ATOM   1155 C CB  . SER A 1 150 ? 29.728 -12.403 3.382   1.00 21.28 ? 177 SER A CB  1 
ATOM   1156 O OG  . SER A 1 150 ? 30.020 -12.164 2.013   1.00 21.13 ? 177 SER A OG  1 
ATOM   1157 N N   . GLU A 1 151 ? 26.889 -12.365 1.706   1.00 27.39 ? 178 GLU A N   1 
ATOM   1158 C CA  . GLU A 1 151 ? 25.960 -11.452 1.063   1.00 30.47 ? 178 GLU A CA  1 
ATOM   1159 C C   . GLU A 1 151 ? 24.503 -11.889 1.221   1.00 27.56 ? 178 GLU A C   1 
ATOM   1160 O O   . GLU A 1 151 ? 23.629 -11.197 0.710   1.00 28.23 ? 178 GLU A O   1 
ATOM   1161 C CB  . GLU A 1 151 ? 26.353 -11.312 -0.407  1.00 30.15 ? 178 GLU A CB  1 
ATOM   1162 C CG  . GLU A 1 151 ? 27.824 -10.923 -0.566  1.00 33.11 ? 178 GLU A CG  1 
ATOM   1163 C CD  . GLU A 1 151 ? 28.319 -9.725  0.257   1.00 33.11 ? 178 GLU A CD  1 
ATOM   1164 O OE1 . GLU A 1 151 ? 27.762 -8.643  -0.004  1.00 35.01 ? 178 GLU A OE1 1 
ATOM   1165 O OE2 . GLU A 1 151 ? 29.217 -9.837  1.147   1.00 30.75 ? 178 GLU A OE2 1 
ATOM   1166 N N   . SER A 1 152 ? 24.263 -12.995 1.939   1.00 24.50 ? 179 SER A N   1 
ATOM   1167 C CA  . SER A 1 152 ? 22.975 -13.677 1.940   1.00 23.28 ? 179 SER A CA  1 
ATOM   1168 C C   . SER A 1 152 ? 21.917 -12.908 2.730   1.00 22.33 ? 179 SER A C   1 
ATOM   1169 O O   . SER A 1 152 ? 22.062 -12.697 3.936   1.00 22.42 ? 179 SER A O   1 
ATOM   1170 C CB  . SER A 1 152 ? 23.087 -15.048 2.487   1.00 22.79 ? 179 SER A CB  1 
ATOM   1171 O OG  . SER A 1 152 ? 21.790 -15.603 2.599   1.00 20.47 ? 179 SER A OG  1 
ATOM   1172 N N   . ASN A 1 153 ? 20.824 -12.591 2.043   1.00 23.29 ? 180 ASN A N   1 
ATOM   1173 C CA  . ASN A 1 153 ? 19.615 -12.029 2.632   1.00 23.71 ? 180 ASN A CA  1 
ATOM   1174 C C   . ASN A 1 153 ? 18.949 -13.017 3.577   1.00 24.23 ? 180 ASN A C   1 
ATOM   1175 O O   . ASN A 1 153 ? 18.579 -12.651 4.687   1.00 20.08 ? 180 ASN A O   1 
ATOM   1176 C CB  . ASN A 1 153 ? 18.574 -11.693 1.583   1.00 25.54 ? 180 ASN A CB  1 
ATOM   1177 C CG  . ASN A 1 153 ? 19.030 -10.569 0.689   1.00 30.20 ? 180 ASN A CG  1 
ATOM   1178 O OD1 . ASN A 1 153 ? 18.910 -9.395  1.063   1.00 32.47 ? 180 ASN A OD1 1 
ATOM   1179 N ND2 . ASN A 1 153 ? 19.506 -10.910 -0.498  1.00 28.22 ? 180 ASN A ND2 1 
ATOM   1180 N N   . PHE A 1 154 ? 18.815 -14.267 3.110   1.00 25.62 ? 181 PHE A N   1 
ATOM   1181 C CA  . PHE A 1 154 ? 18.110 -15.298 3.853   1.00 24.51 ? 181 PHE A CA  1 
ATOM   1182 C C   . PHE A 1 154 ? 18.809 -15.575 5.178   1.00 24.87 ? 181 PHE A C   1 
ATOM   1183 O O   . PHE A 1 154 ? 18.150 -15.580 6.218   1.00 26.43 ? 181 PHE A O   1 
ATOM   1184 C CB  . PHE A 1 154 ? 17.951 -16.563 3.006   1.00 25.08 ? 181 PHE A CB  1 
ATOM   1185 C CG  . PHE A 1 154 ? 17.179 -17.612 3.786   1.00 26.38 ? 181 PHE A CG  1 
ATOM   1186 C CD1 . PHE A 1 154 ? 15.797 -17.545 3.881   1.00 29.48 ? 181 PHE A CD1 1 
ATOM   1187 C CD2 . PHE A 1 154 ? 17.833 -18.602 4.501   1.00 25.66 ? 181 PHE A CD2 1 
ATOM   1188 C CE1 . PHE A 1 154 ? 15.087 -18.489 4.606   1.00 29.33 ? 181 PHE A CE1 1 
ATOM   1189 C CE2 . PHE A 1 154 ? 17.113 -19.538 5.226   1.00 27.26 ? 181 PHE A CE2 1 
ATOM   1190 C CZ  . PHE A 1 154 ? 15.746 -19.475 5.279   1.00 27.35 ? 181 PHE A CZ  1 
ATOM   1191 N N   . ALA A 1 155 ? 20.135 -15.783 5.138   1.00 24.40 ? 182 ALA A N   1 
ATOM   1192 C CA  . ALA A 1 155 ? 20.897 -16.099 6.334   1.00 26.99 ? 182 ALA A CA  1 
ATOM   1193 C C   . ALA A 1 155 ? 20.708 -15.005 7.378   1.00 26.65 ? 182 ALA A C   1 
ATOM   1194 O O   . ALA A 1 155 ? 20.477 -15.310 8.537   1.00 27.72 ? 182 ALA A O   1 
ATOM   1195 C CB  . ALA A 1 155 ? 22.372 -16.315 6.019   1.00 26.77 ? 182 ALA A CB  1 
ATOM   1196 N N   . ARG A 1 156 ? 20.849 -13.749 6.952   1.00 34.08 ? 183 ARG A N   1 
ATOM   1197 C CA  . ARG A 1 156 ? 20.682 -12.581 7.808   1.00 35.72 ? 183 ARG A CA  1 
ATOM   1198 C C   . ARG A 1 156 ? 19.263 -12.530 8.367   1.00 30.42 ? 183 ARG A C   1 
ATOM   1199 O O   . ARG A 1 156 ? 19.081 -12.504 9.570   1.00 30.31 ? 183 ARG A O   1 
ATOM   1200 C CB  . ARG A 1 156 ? 21.057 -11.309 7.039   1.00 40.73 ? 183 ARG A CB  1 
ATOM   1201 C CG  . ARG A 1 156 ? 20.768 -10.009 7.781   1.00 52.07 ? 183 ARG A CG  1 
ATOM   1202 C CD  . ARG A 1 156 ? 21.446 -8.790  7.162   1.00 62.23 ? 183 ARG A CD  1 
ATOM   1203 N NE  . ARG A 1 156 ? 22.872 -9.032  6.904   1.00 72.56 ? 183 ARG A NE  1 
ATOM   1204 C CZ  . ARG A 1 156 ? 23.884 -8.763  7.733   1.00 74.64 ? 183 ARG A CZ  1 
ATOM   1205 N NH1 . ARG A 1 156 ? 25.127 -8.914  7.318   1.00 73.41 ? 183 ARG A NH1 1 
ATOM   1206 N NH2 . ARG A 1 156 ? 23.663 -8.314  8.957   1.00 73.88 ? 183 ARG A NH2 1 
ATOM   1207 N N   . ALA A 1 157 ? 18.249 -12.546 7.505   1.00 28.81 ? 184 ALA A N   1 
ATOM   1208 C CA  . ALA A 1 157 ? 16.874 -12.438 7.974   1.00 30.88 ? 184 ALA A CA  1 
ATOM   1209 C C   . ALA A 1 157 ? 16.465 -13.611 8.878   1.00 33.04 ? 184 ALA A C   1 
ATOM   1210 O O   . ALA A 1 157 ? 15.716 -13.408 9.827   1.00 31.79 ? 184 ALA A O   1 
ATOM   1211 C CB  . ALA A 1 157 ? 15.934 -12.288 6.807   1.00 32.42 ? 184 ALA A CB  1 
ATOM   1212 N N   . TYR A 1 158 ? 16.990 -14.821 8.658   1.00 32.07 ? 185 TYR A N   1 
ATOM   1213 C CA  . TYR A 1 158 ? 16.536 -15.960 9.441   1.00 30.93 ? 185 TYR A CA  1 
ATOM   1214 C C   . TYR A 1 158 ? 16.942 -15.797 10.901  1.00 35.95 ? 185 TYR A C   1 
ATOM   1215 O O   . TYR A 1 158 ? 16.203 -16.185 11.796  1.00 35.10 ? 185 TYR A O   1 
ATOM   1216 C CB  . TYR A 1 158 ? 17.130 -17.300 9.015   1.00 30.89 ? 185 TYR A CB  1 
ATOM   1217 C CG  . TYR A 1 158 ? 16.514 -18.498 9.727   1.00 30.93 ? 185 TYR A CG  1 
ATOM   1218 C CD1 . TYR A 1 158 ? 15.345 -19.079 9.246   1.00 30.08 ? 185 TYR A CD1 1 
ATOM   1219 C CD2 . TYR A 1 158 ? 17.090 -19.033 10.877  1.00 28.43 ? 185 TYR A CD2 1 
ATOM   1220 C CE1 . TYR A 1 158 ? 14.772 -20.173 9.876   1.00 30.35 ? 185 TYR A CE1 1 
ATOM   1221 C CE2 . TYR A 1 158 ? 16.511 -20.113 11.530  1.00 28.91 ? 185 TYR A CE2 1 
ATOM   1222 C CZ  . TYR A 1 158 ? 15.364 -20.686 11.017  1.00 27.10 ? 185 TYR A CZ  1 
ATOM   1223 O OH  . TYR A 1 158 ? 14.795 -21.761 11.592  1.00 32.20 ? 185 TYR A OH  1 
ATOM   1224 N N   . ALA A 1 159 ? 18.155 -15.283 11.113  1.00 41.82 ? 186 ALA A N   1 
ATOM   1225 C CA  . ALA A 1 159 ? 18.721 -15.128 12.445  1.00 46.53 ? 186 ALA A CA  1 
ATOM   1226 C C   . ALA A 1 159 ? 17.953 -14.065 13.235  1.00 45.55 ? 186 ALA A C   1 
ATOM   1227 O O   . ALA A 1 159 ? 17.962 -14.092 14.458  1.00 54.24 ? 186 ALA A O   1 
ATOM   1228 C CB  . ALA A 1 159 ? 20.201 -14.800 12.328  1.00 46.16 ? 186 ALA A CB  1 
ATOM   1229 N N   . GLN A 1 160 ? 17.269 -13.154 12.534  1.00 45.69 ? 187 GLN A N   1 
ATOM   1230 C CA  . GLN A 1 160 ? 16.422 -12.143 13.151  1.00 45.78 ? 187 GLN A CA  1 
ATOM   1231 C C   . GLN A 1 160 ? 14.985 -12.625 13.338  1.00 46.23 ? 187 GLN A C   1 
ATOM   1232 O O   . GLN A 1 160 ? 14.134 -11.846 13.757  1.00 47.11 ? 187 GLN A O   1 
ATOM   1233 C CB  . GLN A 1 160 ? 16.413 -10.887 12.276  1.00 49.16 ? 187 GLN A CB  1 
ATOM   1234 C CG  . GLN A 1 160 ? 17.765 -10.184 12.213  1.00 53.84 ? 187 GLN A CG  1 
ATOM   1235 C CD  . GLN A 1 160 ? 17.725 -8.882  11.444  1.00 57.85 ? 187 GLN A CD  1 
ATOM   1236 O OE1 . GLN A 1 160 ? 17.551 -8.861  10.222  1.00 58.52 ? 187 GLN A OE1 1 
ATOM   1237 N NE2 . GLN A 1 160 ? 17.889 -7.779  12.159  1.00 62.41 ? 187 GLN A NE2 1 
ATOM   1238 N N   . GLY A 1 161 ? 14.714 -13.892 13.024  1.00 43.18 ? 188 GLY A N   1 
ATOM   1239 C CA  . GLY A 1 161 ? 13.348 -14.422 13.190  1.00 42.31 ? 188 GLY A CA  1 
ATOM   1240 C C   . GLY A 1 161 ? 12.434 -13.929 12.086  1.00 50.21 ? 188 GLY A C   1 
ATOM   1241 O O   . GLY A 1 161 ? 11.980 -12.768 12.160  1.00 61.71 ? 188 GLY A O   1 
ATOM   1242 N N   . ILE A 1 162 ? 12.148 -14.781 11.104  1.00 50.90 ? 189 ILE A N   1 
ATOM   1243 C CA  . ILE A 1 162 ? 11.324 -14.399 9.967   1.00 48.96 ? 189 ILE A CA  1 
ATOM   1244 C C   . ILE A 1 162 ? 10.269 -15.489 9.789   1.00 41.53 ? 189 ILE A C   1 
ATOM   1245 O O   . ILE A 1 162 ? 10.539 -16.655 10.029  1.00 41.60 ? 189 ILE A O   1 
ATOM   1246 C CB  . ILE A 1 162 ? 12.200 -14.158 8.711   1.00 55.68 ? 189 ILE A CB  1 
ATOM   1247 C CG1 . ILE A 1 162 ? 11.523 -13.232 7.699   1.00 59.62 ? 189 ILE A CG1 1 
ATOM   1248 C CG2 . ILE A 1 162 ? 12.668 -15.458 8.053   1.00 52.55 ? 189 ILE A CG2 1 
ATOM   1249 C CD1 . ILE A 1 162 ? 11.598 -11.754 8.055   1.00 59.52 ? 189 ILE A CD1 1 
ATOM   1250 N N   . SER A 1 163 ? 9.048  -15.106 9.417   1.00 38.28 ? 190 SER A N   1 
ATOM   1251 C CA  . SER A 1 163 ? 7.994  -16.079 9.194   1.00 39.58 ? 190 SER A CA  1 
ATOM   1252 C C   . SER A 1 163 ? 8.439  -17.129 8.173   1.00 38.23 ? 190 SER A C   1 
ATOM   1253 O O   . SER A 1 163 ? 9.143  -16.802 7.222   1.00 38.06 ? 190 SER A O   1 
ATOM   1254 C CB  . SER A 1 163 ? 6.729  -15.378 8.751   1.00 40.54 ? 190 SER A CB  1 
ATOM   1255 O OG  . SER A 1 163 ? 5.741  -16.307 8.341   1.00 41.79 ? 190 SER A OG  1 
ATOM   1256 N N   . ARG A 1 164 ? 7.981  -18.375 8.363   1.00 37.52 ? 191 ARG A N   1 
ATOM   1257 C CA  . ARG A 1 164 ? 8.150  -19.441 7.390   1.00 42.78 ? 191 ARG A CA  1 
ATOM   1258 C C   . ARG A 1 164 ? 7.624  -19.029 6.012   1.00 43.35 ? 191 ARG A C   1 
ATOM   1259 O O   . ARG A 1 164 ? 8.170  -19.468 4.996   1.00 36.86 ? 191 ARG A O   1 
ATOM   1260 C CB  . ARG A 1 164 ? 7.411  -20.713 7.815   1.00 49.90 ? 191 ARG A CB  1 
ATOM   1261 C CG  . ARG A 1 164 ? 8.038  -21.522 8.941   1.00 57.89 ? 191 ARG A CG  1 
ATOM   1262 C CD  . ARG A 1 164 ? 7.344  -22.885 9.113   1.00 67.26 ? 191 ARG A CD  1 
ATOM   1263 N NE  . ARG A 1 164 ? 7.977  -23.981 8.359   1.00 72.21 ? 191 ARG A NE  1 
ATOM   1264 C CZ  . ARG A 1 164 ? 7.459  -24.769 7.402   1.00 65.90 ? 191 ARG A CZ  1 
ATOM   1265 N NH1 . ARG A 1 164 ? 6.247  -24.569 6.914   1.00 68.35 ? 191 ARG A NH1 1 
ATOM   1266 N NH2 . ARG A 1 164 ? 8.177  -25.770 6.921   1.00 65.48 ? 191 ARG A NH2 1 
ATOM   1267 N N   . THR A 1 165 ? 6.580  -18.178 5.975   1.00 41.29 ? 192 THR A N   1 
ATOM   1268 C CA  . THR A 1 165 ? 5.836  -17.911 4.748   1.00 38.67 ? 192 THR A CA  1 
ATOM   1269 C C   . THR A 1 165 ? 6.632  -16.950 3.875   1.00 33.80 ? 192 THR A C   1 
ATOM   1270 O O   . THR A 1 165 ? 6.337  -16.813 2.694   1.00 33.47 ? 192 THR A O   1 
ATOM   1271 C CB  . THR A 1 165 ? 4.450  -17.323 5.036   1.00 42.63 ? 192 THR A CB  1 
ATOM   1272 O OG1 . THR A 1 165 ? 4.670  -15.969 5.424   1.00 44.01 ? 192 THR A OG1 1 
ATOM   1273 C CG2 . THR A 1 165 ? 3.691  -18.047 6.134   1.00 43.25 ? 192 THR A CG2 1 
ATOM   1274 N N   . LYS A 1 166 ? 7.614  -16.267 4.473   1.00 34.54 ? 193 LYS A N   1 
ATOM   1275 C CA  . LYS A 1 166 ? 8.397  -15.265 3.777   1.00 36.95 ? 193 LYS A CA  1 
ATOM   1276 C C   . LYS A 1 166 ? 9.754  -15.846 3.367   1.00 33.80 ? 193 LYS A C   1 
ATOM   1277 O O   . LYS A 1 166 ? 10.582 -15.122 2.813   1.00 31.11 ? 193 LYS A O   1 
ATOM   1278 C CB  . LYS A 1 166 ? 8.649  -14.014 4.632   1.00 44.90 ? 193 LYS A CB  1 
ATOM   1279 C CG  . LYS A 1 166 ? 7.629  -13.696 5.738   1.00 55.88 ? 193 LYS A CG  1 
ATOM   1280 C CD  . LYS A 1 166 ? 6.623  -12.558 5.564   1.00 62.84 ? 193 LYS A CD  1 
ATOM   1281 C CE  . LYS A 1 166 ? 5.679  -12.698 4.418   1.00 67.08 ? 193 LYS A CE  1 
ATOM   1282 N NZ  . LYS A 1 166 ? 6.161  -11.908 3.289   1.00 74.09 ? 193 LYS A NZ  1 
ATOM   1283 N N   . TYR A 1 167 ? 9.996  -17.142 3.634   1.00 28.69 ? 194 TYR A N   1 
ATOM   1284 C CA  . TYR A 1 167 ? 11.300 -17.723 3.360   1.00 27.68 ? 194 TYR A CA  1 
ATOM   1285 C C   . TYR A 1 167 ? 11.613 -17.607 1.869   1.00 25.64 ? 194 TYR A C   1 
ATOM   1286 O O   . TYR A 1 167 ? 12.685 -17.131 1.510   1.00 22.29 ? 194 TYR A O   1 
ATOM   1287 C CB  . TYR A 1 167 ? 11.496 -19.197 3.723   1.00 27.99 ? 194 TYR A CB  1 
ATOM   1288 C CG  . TYR A 1 167 ? 11.575 -19.586 5.187   1.00 27.98 ? 194 TYR A CG  1 
ATOM   1289 C CD1 . TYR A 1 167 ? 11.771 -18.657 6.205   1.00 32.99 ? 194 TYR A CD1 1 
ATOM   1290 C CD2 . TYR A 1 167 ? 11.407 -20.917 5.550   1.00 29.29 ? 194 TYR A CD2 1 
ATOM   1291 C CE1 . TYR A 1 167 ? 11.802 -19.040 7.541   1.00 31.84 ? 194 TYR A CE1 1 
ATOM   1292 C CE2 . TYR A 1 167 ? 11.466 -21.314 6.869   1.00 30.60 ? 194 TYR A CE2 1 
ATOM   1293 C CZ  . TYR A 1 167 ? 11.674 -20.377 7.867   1.00 34.37 ? 194 TYR A CZ  1 
ATOM   1294 O OH  . TYR A 1 167 ? 11.725 -20.798 9.164   1.00 34.54 ? 194 TYR A OH  1 
ATOM   1295 N N   . TRP A 1 168 ? 10.662 -17.993 1.005   1.00 23.28 ? 195 TRP A N   1 
ATOM   1296 C CA  . TRP A 1 168 ? 10.929 -18.104 -0.417  1.00 24.65 ? 195 TRP A CA  1 
ATOM   1297 C C   . TRP A 1 168 ? 11.382 -16.766 -1.015  1.00 25.52 ? 195 TRP A C   1 
ATOM   1298 O O   . TRP A 1 168 ? 12.111 -16.753 -2.001  1.00 25.79 ? 195 TRP A O   1 
ATOM   1299 C CB  . TRP A 1 168 ? 9.699  -18.650 -1.152  1.00 23.69 ? 195 TRP A CB  1 
ATOM   1300 C CG  . TRP A 1 168 ? 8.567  -17.667 -1.278  1.00 27.54 ? 195 TRP A CG  1 
ATOM   1301 C CD1 . TRP A 1 168 ? 7.500  -17.560 -0.432  1.00 28.79 ? 195 TRP A CD1 1 
ATOM   1302 C CD2 . TRP A 1 168 ? 8.393  -16.638 -2.275  1.00 25.45 ? 195 TRP A CD2 1 
ATOM   1303 N NE1 . TRP A 1 168 ? 6.664  -16.567 -0.852  1.00 27.45 ? 195 TRP A NE1 1 
ATOM   1304 C CE2 . TRP A 1 168 ? 7.178  -15.982 -1.974  1.00 27.81 ? 195 TRP A CE2 1 
ATOM   1305 C CE3 . TRP A 1 168 ? 9.122  -16.227 -3.393  1.00 26.57 ? 195 TRP A CE3 1 
ATOM   1306 C CZ2 . TRP A 1 168 ? 6.691  -14.919 -2.730  1.00 28.24 ? 195 TRP A CZ2 1 
ATOM   1307 C CZ3 . TRP A 1 168 ? 8.649  -15.172 -4.141  1.00 28.41 ? 195 TRP A CZ3 1 
ATOM   1308 C CH2 . TRP A 1 168 ? 7.460  -14.513 -3.799  1.00 30.10 ? 195 TRP A CH2 1 
ATOM   1309 N N   . GLU A 1 169 ? 10.915 -15.646 -0.447  1.00 24.42 ? 196 GLU A N   1 
ATOM   1310 C CA  . GLU A 1 169 ? 11.202 -14.334 -1.006  1.00 25.06 ? 196 GLU A CA  1 
ATOM   1311 C C   . GLU A 1 169 ? 12.703 -14.027 -0.894  1.00 23.88 ? 196 GLU A C   1 
ATOM   1312 O O   . GLU A 1 169 ? 13.305 -13.516 -1.840  1.00 21.74 ? 196 GLU A O   1 
ATOM   1313 C CB  . GLU A 1 169 ? 10.408 -13.229 -0.299  1.00 27.70 ? 196 GLU A CB  1 
ATOM   1314 C CG  . GLU A 1 169 ? 8.905  -13.486 -0.223  1.00 29.60 ? 196 GLU A CG  1 
ATOM   1315 C CD  . GLU A 1 169 ? 8.148  -12.374 0.482   1.00 39.21 ? 196 GLU A CD  1 
ATOM   1316 O OE1 . GLU A 1 169 ? 8.791  -11.391 0.950   1.00 42.36 ? 196 GLU A OE1 1 
ATOM   1317 O OE2 . GLU A 1 169 ? 6.903  -12.468 0.527   1.00 37.93 ? 196 GLU A OE2 1 
ATOM   1318 N N   . LEU A 1 170 ? 13.295 -14.327 0.267   1.00 21.44 ? 197 LEU A N   1 
ATOM   1319 C CA  . LEU A 1 170 ? 14.696 -14.042 0.499   1.00 24.27 ? 197 LEU A CA  1 
ATOM   1320 C C   . LEU A 1 170 ? 15.549 -15.040 -0.277  1.00 22.55 ? 197 LEU A C   1 
ATOM   1321 O O   . LEU A 1 170 ? 16.641 -14.708 -0.731  1.00 22.23 ? 197 LEU A O   1 
ATOM   1322 C CB  . LEU A 1 170 ? 14.942 -14.123 2.001   1.00 28.03 ? 197 LEU A CB  1 
ATOM   1323 C CG  . LEU A 1 170 ? 14.164 -13.096 2.827   1.00 30.22 ? 197 LEU A CG  1 
ATOM   1324 C CD1 . LEU A 1 170 ? 13.697 -13.747 4.132   1.00 32.48 ? 197 LEU A CD1 1 
ATOM   1325 C CD2 . LEU A 1 170 ? 15.008 -11.848 3.062   1.00 31.03 ? 197 LEU A CD2 1 
ATOM   1326 N N   . ILE A 1 171 ? 15.027 -16.261 -0.402  1.00 20.24 ? 198 ILE A N   1 
ATOM   1327 C CA  . ILE A 1 171 ? 15.645 -17.325 -1.175  1.00 20.65 ? 198 ILE A CA  1 
ATOM   1328 C C   . ILE A 1 171 ? 15.675 -16.936 -2.648  1.00 19.54 ? 198 ILE A C   1 
ATOM   1329 O O   . ILE A 1 171 ? 16.687 -17.129 -3.297  1.00 19.70 ? 198 ILE A O   1 
ATOM   1330 C CB  . ILE A 1 171 ? 14.912 -18.661 -0.938  1.00 20.93 ? 198 ILE A CB  1 
ATOM   1331 C CG1 . ILE A 1 171 ? 14.988 -19.077 0.513   1.00 21.42 ? 198 ILE A CG1 1 
ATOM   1332 C CG2 . ILE A 1 171 ? 15.424 -19.761 -1.864  1.00 20.28 ? 198 ILE A CG2 1 
ATOM   1333 C CD1 . ILE A 1 171 ? 16.314 -19.698 0.900   1.00 23.91 ? 198 ILE A CD1 1 
ATOM   1334 N N   . TYR A 1 172 ? 14.578 -16.367 -3.149  1.00 18.49 ? 199 TYR A N   1 
ATOM   1335 C CA  . TYR A 1 172 ? 14.543 -15.801 -4.481  1.00 21.45 ? 199 TYR A CA  1 
ATOM   1336 C C   . TYR A 1 172 ? 15.632 -14.747 -4.643  1.00 20.43 ? 199 TYR A C   1 
ATOM   1337 O O   . TYR A 1 172 ? 16.390 -14.805 -5.618  1.00 22.81 ? 199 TYR A O   1 
ATOM   1338 C CB  . TYR A 1 172 ? 13.151 -15.247 -4.805  1.00 22.69 ? 199 TYR A CB  1 
ATOM   1339 C CG  . TYR A 1 172 ? 13.093 -14.315 -6.002  1.00 22.24 ? 199 TYR A CG  1 
ATOM   1340 C CD1 . TYR A 1 172 ? 13.276 -12.938 -5.858  1.00 20.65 ? 199 TYR A CD1 1 
ATOM   1341 C CD2 . TYR A 1 172 ? 12.841 -14.823 -7.263  1.00 21.94 ? 199 TYR A CD2 1 
ATOM   1342 C CE1 . TYR A 1 172 ? 13.248 -12.094 -6.951  1.00 21.46 ? 199 TYR A CE1 1 
ATOM   1343 C CE2 . TYR A 1 172 ? 12.805 -13.993 -8.359  1.00 24.87 ? 199 TYR A CE2 1 
ATOM   1344 C CZ  . TYR A 1 172 ? 12.988 -12.629 -8.198  1.00 23.27 ? 199 TYR A CZ  1 
ATOM   1345 O OH  . TYR A 1 172 ? 12.951 -11.872 -9.308  1.00 24.23 ? 199 TYR A OH  1 
ATOM   1346 N N   . GLU A 1 173 ? 15.698 -13.796 -3.711  1.00 20.71 ? 200 GLU A N   1 
ATOM   1347 C CA  . GLU A 1 173 ? 16.629 -12.690 -3.839  1.00 20.42 ? 200 GLU A CA  1 
ATOM   1348 C C   . GLU A 1 173 ? 18.062 -13.217 -3.929  1.00 20.27 ? 200 GLU A C   1 
ATOM   1349 O O   . GLU A 1 173 ? 18.804 -12.807 -4.803  1.00 20.97 ? 200 GLU A O   1 
ATOM   1350 C CB  . GLU A 1 173 ? 16.448 -11.666 -2.723  1.00 21.59 ? 200 GLU A CB  1 
ATOM   1351 C CG  . GLU A 1 173 ? 15.158 -10.841 -2.820  1.00 22.52 ? 200 GLU A CG  1 
ATOM   1352 C CD  . GLU A 1 173 ? 14.865 -10.094 -4.110  1.00 23.93 ? 200 GLU A CD  1 
ATOM   1353 O OE1 . GLU A 1 173 ? 15.802 -9.926  -4.889  1.00 24.64 ? 200 GLU A OE1 1 
ATOM   1354 O OE2 . GLU A 1 173 ? 13.709 -9.650  -4.344  1.00 23.79 ? 200 GLU A OE2 1 
ATOM   1355 N N   . ASP A 1 174 ? 18.439 -14.146 -3.041  1.00 21.53 ? 201 ASP A N   1 
ATOM   1356 C CA  . ASP A 1 174 ? 19.779 -14.723 -3.000  1.00 21.71 ? 201 ASP A CA  1 
ATOM   1357 C C   . ASP A 1 174 ? 20.090 -15.509 -4.276  1.00 21.28 ? 201 ASP A C   1 
ATOM   1358 O O   . ASP A 1 174 ? 21.197 -15.417 -4.807  1.00 19.45 ? 201 ASP A O   1 
ATOM   1359 C CB  . ASP A 1 174 ? 19.934 -15.581 -1.762  1.00 21.34 ? 201 ASP A CB  1 
ATOM   1360 C CG  . ASP A 1 174 ? 20.118 -14.807 -0.465  1.00 23.62 ? 201 ASP A CG  1 
ATOM   1361 O OD1 . ASP A 1 174 ? 20.329 -13.567 -0.561  1.00 26.65 ? 201 ASP A OD1 1 
ATOM   1362 O OD2 . ASP A 1 174 ? 20.052 -15.434 0.620   1.00 23.58 ? 201 ASP A OD2 1 
ATOM   1363 N N   . SER A 1 175 ? 19.101 -16.262 -4.754  1.00 20.84 ? 202 SER A N   1 
ATOM   1364 C CA  . SER A 1 175 ? 19.233 -17.087 -5.948  1.00 22.62 ? 202 SER A CA  1 
ATOM   1365 C C   . SER A 1 175 ? 19.490 -16.241 -7.194  1.00 22.20 ? 202 SER A C   1 
ATOM   1366 O O   . SER A 1 175 ? 20.387 -16.559 -7.969  1.00 22.80 ? 202 SER A O   1 
ATOM   1367 C CB  . SER A 1 175 ? 18.010 -17.953 -6.115  1.00 23.74 ? 202 SER A CB  1 
ATOM   1368 O OG  . SER A 1 175 ? 17.983 -18.896 -5.061  1.00 22.41 ? 202 SER A OG  1 
ATOM   1369 N N   . MET A 1 176 ? 18.761 -15.125 -7.324  1.00 20.07 ? 203 MET A N   1 
ATOM   1370 C CA  . MET A 1 176 ? 18.947 -14.192 -8.422  1.00 23.16 ? 203 MET A CA  1 
ATOM   1371 C C   . MET A 1 176 ? 20.315 -13.538 -8.319  1.00 22.45 ? 203 MET A C   1 
ATOM   1372 O O   . MET A 1 176 ? 20.961 -13.353 -9.341  1.00 21.53 ? 203 MET A O   1 
ATOM   1373 C CB  . MET A 1 176 ? 17.880 -13.092 -8.442  1.00 22.40 ? 203 MET A CB  1 
ATOM   1374 C CG  . MET A 1 176 ? 16.472 -13.627 -8.657  1.00 22.94 ? 203 MET A CG  1 
ATOM   1375 S SD  . MET A 1 176 ? 16.079 -13.933 -10.393 1.00 26.80 ? 203 MET A SD  1 
ATOM   1376 C CE  . MET A 1 176 ? 15.813 -12.228 -10.915 1.00 25.21 ? 203 MET A CE  1 
ATOM   1377 N N   . ASP A 1 177 ? 20.736 -13.224 -7.093  1.00 21.49 ? 204 ASP A N   1 
ATOM   1378 C CA  . ASP A 1 177 ? 22.036 -12.625 -6.853  1.00 22.71 ? 204 ASP A CA  1 
ATOM   1379 C C   . ASP A 1 177 ? 23.140 -13.618 -7.228  1.00 22.48 ? 204 ASP A C   1 
ATOM   1380 O O   . ASP A 1 177 ? 24.125 -13.235 -7.852  1.00 19.94 ? 204 ASP A O   1 
ATOM   1381 C CB  . ASP A 1 177 ? 22.169 -12.109 -5.425  1.00 23.25 ? 204 ASP A CB  1 
ATOM   1382 C CG  . ASP A 1 177 ? 21.467 -10.791 -5.066  1.00 28.22 ? 204 ASP A CG  1 
ATOM   1383 O OD1 . ASP A 1 177 ? 20.914 -10.122 -5.981  1.00 25.03 ? 204 ASP A OD1 1 
ATOM   1384 O OD2 . ASP A 1 177 ? 21.446 -10.448 -3.840  1.00 26.38 ? 204 ASP A OD2 1 
ATOM   1385 N N   . LEU A 1 178 ? 22.960 -14.895 -6.870  1.00 21.08 ? 205 LEU A N   1 
ATOM   1386 C CA  . LEU A 1 178 ? 23.989 -15.889 -7.096  1.00 20.72 ? 205 LEU A CA  1 
ATOM   1387 C C   . LEU A 1 178 ? 24.107 -16.181 -8.592  1.00 20.96 ? 205 LEU A C   1 
ATOM   1388 O O   . LEU A 1 178 ? 25.200 -16.173 -9.153  1.00 20.47 ? 205 LEU A O   1 
ATOM   1389 C CB  . LEU A 1 178 ? 23.675 -17.152 -6.299  1.00 20.70 ? 205 LEU A CB  1 
ATOM   1390 C CG  . LEU A 1 178 ? 24.587 -18.357 -6.556  1.00 20.33 ? 205 LEU A CG  1 
ATOM   1391 C CD1 . LEU A 1 178 ? 26.080 -18.055 -6.438  1.00 20.10 ? 205 LEU A CD1 1 
ATOM   1392 C CD2 . LEU A 1 178 ? 24.161 -19.423 -5.568  1.00 20.86 ? 205 LEU A CD2 1 
ATOM   1393 N N   . ILE A 1 179 ? 22.982 -16.446 -9.247  1.00 21.24 ? 206 ILE A N   1 
ATOM   1394 C CA  . ILE A 1 179 ? 22.986 -16.612 -10.690 1.00 20.82 ? 206 ILE A CA  1 
ATOM   1395 C C   . ILE A 1 179 ? 23.728 -15.443 -11.355 1.00 20.73 ? 206 ILE A C   1 
ATOM   1396 O O   . ILE A 1 179 ? 24.626 -15.661 -12.158 1.00 18.25 ? 206 ILE A O   1 
ATOM   1397 C CB  . ILE A 1 179 ? 21.559 -16.789 -11.219 1.00 20.70 ? 206 ILE A CB  1 
ATOM   1398 C CG1 . ILE A 1 179 ? 21.004 -18.131 -10.762 1.00 21.82 ? 206 ILE A CG1 1 
ATOM   1399 C CG2 . ILE A 1 179 ? 21.547 -16.690 -12.742 1.00 21.63 ? 206 ILE A CG2 1 
ATOM   1400 C CD1 . ILE A 1 179 ? 19.502 -18.156 -10.627 1.00 24.19 ? 206 ILE A CD1 1 
ATOM   1401 N N   . ALA A 1 180 ? 23.408 -14.206 -10.961 1.00 19.46 ? 207 ALA A N   1 
ATOM   1402 C CA  . ALA A 1 180 ? 24.055 -13.048 -11.541 1.00 19.78 ? 207 ALA A CA  1 
ATOM   1403 C C   . ALA A 1 180 ? 25.573 -13.109 -11.395 1.00 19.55 ? 207 ALA A C   1 
ATOM   1404 O O   . ALA A 1 180 ? 26.326 -12.736 -12.301 1.00 20.14 ? 207 ALA A O   1 
ATOM   1405 C CB  . ALA A 1 180 ? 23.528 -11.797 -10.903 1.00 18.58 ? 207 ALA A CB  1 
ATOM   1406 N N   . LYS A 1 181 ? 26.032 -13.423 -10.199 1.00 18.84 ? 208 LYS A N   1 
ATOM   1407 C CA  . LYS A 1 181 ? 27.443 -13.307 -9.900  1.00 20.71 ? 208 LYS A CA  1 
ATOM   1408 C C   . LYS A 1 181 ? 28.237 -14.482 -10.457 1.00 20.13 ? 208 LYS A C   1 
ATOM   1409 O O   . LYS A 1 181 ? 29.448 -14.393 -10.592 1.00 19.08 ? 208 LYS A O   1 
ATOM   1410 C CB  . LYS A 1 181 ? 27.647 -13.273 -8.381  1.00 21.45 ? 208 LYS A CB  1 
ATOM   1411 C CG  . LYS A 1 181 ? 27.154 -12.028 -7.710  1.00 22.33 ? 208 LYS A CG  1 
ATOM   1412 C CD  . LYS A 1 181 ? 27.010 -12.207 -6.210  1.00 24.69 ? 208 LYS A CD  1 
ATOM   1413 C CE  . LYS A 1 181 ? 26.958 -10.934 -5.466  1.00 28.25 ? 208 LYS A CE  1 
ATOM   1414 N NZ  . LYS A 1 181 ? 26.132 -9.906  -6.085  1.00 29.76 ? 208 LYS A NZ  1 
ATOM   1415 N N   . LEU A 1 182 ? 27.570 -15.600 -10.720 1.00 21.21 ? 209 LEU A N   1 
ATOM   1416 C CA  . LEU A 1 182 ? 28.272 -16.827 -11.043 1.00 23.15 ? 209 LEU A CA  1 
ATOM   1417 C C   . LEU A 1 182 ? 29.156 -16.692 -12.282 1.00 22.42 ? 209 LEU A C   1 
ATOM   1418 O O   . LEU A 1 182 ? 30.252 -17.228 -12.299 1.00 23.65 ? 209 LEU A O   1 
ATOM   1419 C CB  . LEU A 1 182 ? 27.289 -17.985 -11.207 1.00 21.96 ? 209 LEU A CB  1 
ATOM   1420 C CG  . LEU A 1 182 ? 27.146 -18.874 -9.970  1.00 22.76 ? 209 LEU A CG  1 
ATOM   1421 C CD1 . LEU A 1 182 ? 25.895 -19.742 -10.080 1.00 21.87 ? 209 LEU A CD1 1 
ATOM   1422 C CD2 . LEU A 1 182 ? 28.405 -19.694 -9.792  1.00 23.79 ? 209 LEU A CD2 1 
ATOM   1423 N N   . PRO A 1 183 ? 28.710 -16.099 -13.407 1.00 24.52 ? 210 PRO A N   1 
ATOM   1424 C CA  . PRO A 1 183 ? 29.612 -15.907 -14.546 1.00 25.76 ? 210 PRO A CA  1 
ATOM   1425 C C   . PRO A 1 183 ? 30.832 -15.059 -14.179 1.00 24.92 ? 210 PRO A C   1 
ATOM   1426 O O   . PRO A 1 183 ? 31.926 -15.331 -14.660 1.00 26.65 ? 210 PRO A O   1 
ATOM   1427 C CB  . PRO A 1 183 ? 28.721 -15.259 -15.608 1.00 25.33 ? 210 PRO A CB  1 
ATOM   1428 C CG  . PRO A 1 183 ? 27.347 -15.685 -15.198 1.00 25.61 ? 210 PRO A CG  1 
ATOM   1429 C CD  . PRO A 1 183 ? 27.349 -15.633 -13.686 1.00 24.51 ? 210 PRO A CD  1 
ATOM   1430 N N   . CYS A 1 184 ? 30.676 -14.074 -13.284 1.00 25.78 ? 211 CYS A N   1 
ATOM   1431 C CA  . CYS A 1 184 ? 31.819 -13.265 -12.867 1.00 25.21 ? 211 CYS A CA  1 
ATOM   1432 C C   . CYS A 1 184 ? 32.831 -14.105 -12.100 1.00 24.27 ? 211 CYS A C   1 
ATOM   1433 O O   . CYS A 1 184 ? 34.042 -14.009 -12.348 1.00 22.67 ? 211 CYS A O   1 
ATOM   1434 C CB  . CYS A 1 184 ? 31.423 -12.097 -11.976 1.00 29.05 ? 211 CYS A CB  1 
ATOM   1435 S SG  . CYS A 1 184 ? 30.319 -10.938 -12.821 1.00 33.05 ? 211 CYS A SG  1 
ATOM   1436 N N   . VAL A 1 185 ? 32.313 -14.948 -11.204 1.00 20.62 ? 212 VAL A N   1 
ATOM   1437 C CA  . VAL A 1 185 ? 33.155 -15.832 -10.418 1.00 21.32 ? 212 VAL A CA  1 
ATOM   1438 C C   . VAL A 1 185 ? 33.883 -16.778 -11.366 1.00 20.72 ? 212 VAL A C   1 
ATOM   1439 O O   . VAL A 1 185 ? 35.107 -16.913 -11.280 1.00 19.23 ? 212 VAL A O   1 
ATOM   1440 C CB  . VAL A 1 185 ? 32.387 -16.625 -9.341  1.00 22.05 ? 212 VAL A CB  1 
ATOM   1441 C CG1 . VAL A 1 185 ? 33.229 -17.754 -8.723  1.00 21.48 ? 212 VAL A CG1 1 
ATOM   1442 C CG2 . VAL A 1 185 ? 31.803 -15.719 -8.267  1.00 21.53 ? 212 VAL A CG2 1 
ATOM   1443 N N   . ALA A 1 186 ? 33.096 -17.449 -12.218 1.00 20.92 ? 213 ALA A N   1 
ATOM   1444 C CA  . ALA A 1 186 ? 33.579 -18.444 -13.156 1.00 20.97 ? 213 ALA A CA  1 
ATOM   1445 C C   . ALA A 1 186 ? 34.637 -17.854 -14.085 1.00 22.35 ? 213 ALA A C   1 
ATOM   1446 O O   . ALA A 1 186 ? 35.662 -18.491 -14.354 1.00 20.92 ? 213 ALA A O   1 
ATOM   1447 C CB  . ALA A 1 186 ? 32.415 -19.021 -13.942 1.00 21.31 ? 213 ALA A CB  1 
ATOM   1448 N N   . ALA A 1 187 ? 34.403 -16.614 -14.511 1.00 19.70 ? 214 ALA A N   1 
ATOM   1449 C CA  . ALA A 1 187 ? 35.299 -15.960 -15.443 1.00 21.77 ? 214 ALA A CA  1 
ATOM   1450 C C   . ALA A 1 187 ? 36.582 -15.500 -14.768 1.00 22.17 ? 214 ALA A C   1 
ATOM   1451 O O   . ALA A 1 187 ? 37.617 -15.512 -15.413 1.00 21.66 ? 214 ALA A O   1 
ATOM   1452 C CB  . ALA A 1 187 ? 34.607 -14.811 -16.116 1.00 22.17 ? 214 ALA A CB  1 
ATOM   1453 N N   . LYS A 1 188 ? 36.514 -15.088 -13.498 1.00 22.33 ? 215 LYS A N   1 
ATOM   1454 C CA  . LYS A 1 188 ? 37.713 -14.722 -12.758 1.00 23.04 ? 215 LYS A CA  1 
ATOM   1455 C C   . LYS A 1 188 ? 38.642 -15.935 -12.626 1.00 24.01 ? 215 LYS A C   1 
ATOM   1456 O O   . LYS A 1 188 ? 39.867 -15.807 -12.789 1.00 22.70 ? 215 LYS A O   1 
ATOM   1457 C CB  . LYS A 1 188 ? 37.324 -14.086 -11.424 1.00 25.77 ? 215 LYS A CB  1 
ATOM   1458 C CG  . LYS A 1 188 ? 38.395 -13.290 -10.663 1.00 29.39 ? 215 LYS A CG  1 
ATOM   1459 C CD  . LYS A 1 188 ? 38.164 -11.783 -10.510 1.00 30.14 ? 215 LYS A CD  1 
ATOM   1460 C CE  . LYS A 1 188 ? 39.386 -10.957 -10.855 1.00 26.92 ? 215 LYS A CE  1 
ATOM   1461 N N   . ILE A 1 189 ? 38.060 -17.103 -12.333 1.00 22.43 ? 216 ILE A N   1 
ATOM   1462 C CA  . ILE A 1 189 ? 38.811 -18.344 -12.250 1.00 21.16 ? 216 ILE A CA  1 
ATOM   1463 C C   . ILE A 1 189 ? 39.499 -18.604 -13.593 1.00 21.81 ? 216 ILE A C   1 
ATOM   1464 O O   . ILE A 1 189 ? 40.693 -18.892 -13.633 1.00 21.27 ? 216 ILE A O   1 
ATOM   1465 C CB  . ILE A 1 189 ? 37.882 -19.492 -11.805 1.00 21.93 ? 216 ILE A CB  1 
ATOM   1466 C CG1 . ILE A 1 189 ? 37.416 -19.269 -10.371 1.00 23.01 ? 216 ILE A CG1 1 
ATOM   1467 C CG2 . ILE A 1 189 ? 38.543 -20.857 -11.958 1.00 22.54 ? 216 ILE A CG2 1 
ATOM   1468 C CD1 . ILE A 1 189 ? 36.215 -20.090 -9.974  1.00 23.11 ? 216 ILE A CD1 1 
ATOM   1469 N N   . TYR A 1 190 ? 38.743 -18.513 -14.698 1.00 21.58 ? 217 TYR A N   1 
ATOM   1470 C CA  . TYR A 1 190 ? 39.281 -18.801 -16.021 1.00 21.52 ? 217 TYR A CA  1 
ATOM   1471 C C   . TYR A 1 190 ? 40.448 -17.864 -16.336 1.00 21.41 ? 217 TYR A C   1 
ATOM   1472 O O   . TYR A 1 190 ? 41.499 -18.314 -16.754 1.00 23.60 ? 217 TYR A O   1 
ATOM   1473 C CB  . TYR A 1 190 ? 38.169 -18.697 -17.067 1.00 20.47 ? 217 TYR A CB  1 
ATOM   1474 C CG  . TYR A 1 190 ? 38.607 -19.200 -18.426 1.00 21.09 ? 217 TYR A CG  1 
ATOM   1475 C CD1 . TYR A 1 190 ? 38.608 -20.561 -18.701 1.00 22.63 ? 217 TYR A CD1 1 
ATOM   1476 C CD2 . TYR A 1 190 ? 39.060 -18.329 -19.415 1.00 22.85 ? 217 TYR A CD2 1 
ATOM   1477 C CE1 . TYR A 1 190 ? 39.006 -21.044 -19.933 1.00 22.53 ? 217 TYR A CE1 1 
ATOM   1478 C CE2 . TYR A 1 190 ? 39.495 -18.806 -20.645 1.00 23.64 ? 217 TYR A CE2 1 
ATOM   1479 C CZ  . TYR A 1 190 ? 39.426 -20.160 -20.914 1.00 23.19 ? 217 TYR A CZ  1 
ATOM   1480 O OH  . TYR A 1 190 ? 39.845 -20.670 -22.105 1.00 24.65 ? 217 TYR A OH  1 
ATOM   1481 N N   . ARG A 1 191 ? 40.273 -16.563 -16.086 1.00 22.42 ? 218 ARG A N   1 
ATOM   1482 C CA  . ARG A 1 191 ? 41.300 -15.584 -16.392 1.00 23.71 ? 218 ARG A CA  1 
ATOM   1483 C C   . ARG A 1 191 ? 42.523 -15.748 -15.497 1.00 24.58 ? 218 ARG A C   1 
ATOM   1484 O O   . ARG A 1 191 ? 43.642 -15.637 -15.991 1.00 24.37 ? 218 ARG A O   1 
ATOM   1485 C CB  . ARG A 1 191 ? 40.733 -14.171 -16.279 1.00 24.96 ? 218 ARG A CB  1 
ATOM   1486 C CG  . ARG A 1 191 ? 39.712 -13.844 -17.359 1.00 27.11 ? 218 ARG A CG  1 
ATOM   1487 C CD  . ARG A 1 191 ? 39.794 -12.351 -17.593 1.00 31.88 ? 218 ARG A CD  1 
ATOM   1488 N NE  . ARG A 1 191 ? 38.966 -11.971 -18.727 1.00 38.32 ? 218 ARG A NE  1 
ATOM   1489 C CZ  . ARG A 1 191 ? 39.343 -11.371 -19.837 1.00 37.32 ? 218 ARG A CZ  1 
ATOM   1490 N NH1 . ARG A 1 191 ? 40.617 -11.206 -20.147 1.00 35.89 ? 218 ARG A NH1 1 
ATOM   1491 N NH2 . ARG A 1 191 ? 38.388 -10.929 -20.621 1.00 36.24 ? 218 ARG A NH2 1 
ATOM   1492 N N   . ASN A 1 192 ? 42.311 -16.050 -14.208 1.00 22.10 ? 219 ASN A N   1 
ATOM   1493 C CA  . ASN A 1 192 ? 43.411 -16.181 -13.266 1.00 24.01 ? 219 ASN A CA  1 
ATOM   1494 C C   . ASN A 1 192 ? 44.229 -17.413 -13.616 1.00 23.20 ? 219 ASN A C   1 
ATOM   1495 O O   . ASN A 1 192 ? 45.455 -17.400 -13.532 1.00 26.04 ? 219 ASN A O   1 
ATOM   1496 C CB  . ASN A 1 192 ? 42.905 -16.188 -11.822 1.00 25.25 ? 219 ASN A CB  1 
ATOM   1497 C CG  . ASN A 1 192 ? 42.446 -14.826 -11.359 1.00 25.43 ? 219 ASN A CG  1 
ATOM   1498 O OD1 . ASN A 1 192 ? 42.692 -13.811 -12.027 1.00 27.07 ? 219 ASN A OD1 1 
ATOM   1499 N ND2 . ASN A 1 192 ? 41.753 -14.776 -10.229 1.00 26.44 ? 219 ASN A ND2 1 
ATOM   1500 N N   . LEU A 1 193 ? 43.554 -18.470 -14.066 1.00 22.94 ? 220 LEU A N   1 
ATOM   1501 C CA  . LEU A 1 193 ? 44.233 -19.698 -14.429 1.00 25.19 ? 220 LEU A CA  1 
ATOM   1502 C C   . LEU A 1 193 ? 44.877 -19.610 -15.814 1.00 26.60 ? 220 LEU A C   1 
ATOM   1503 O O   . LEU A 1 193 ? 45.989 -20.101 -15.965 1.00 26.29 ? 220 LEU A O   1 
ATOM   1504 C CB  . LEU A 1 193 ? 43.272 -20.886 -14.330 1.00 25.57 ? 220 LEU A CB  1 
ATOM   1505 C CG  . LEU A 1 193 ? 42.899 -21.333 -12.910 1.00 26.69 ? 220 LEU A CG  1 
ATOM   1506 C CD1 . LEU A 1 193 ? 41.967 -22.547 -12.950 1.00 29.15 ? 220 LEU A CD1 1 
ATOM   1507 C CD2 . LEU A 1 193 ? 44.143 -21.666 -12.123 1.00 29.13 ? 220 LEU A CD2 1 
ATOM   1508 N N   . TYR A 1 194 ? 44.199 -19.035 -16.826 1.00 28.38 ? 221 TYR A N   1 
ATOM   1509 C CA  . TYR A 1 194 ? 44.650 -19.203 -18.211 1.00 27.42 ? 221 TYR A CA  1 
ATOM   1510 C C   . TYR A 1 194 ? 44.832 -17.893 -18.971 1.00 29.19 ? 221 TYR A C   1 
ATOM   1511 O O   . TYR A 1 194 ? 45.211 -17.922 -20.133 1.00 35.22 ? 221 TYR A O   1 
ATOM   1512 C CB  . TYR A 1 194 ? 43.661 -20.037 -19.018 1.00 26.54 ? 221 TYR A CB  1 
ATOM   1513 C CG  . TYR A 1 194 ? 43.172 -21.230 -18.228 1.00 26.14 ? 221 TYR A CG  1 
ATOM   1514 C CD1 . TYR A 1 194 ? 44.056 -22.230 -17.819 1.00 25.43 ? 221 TYR A CD1 1 
ATOM   1515 C CD2 . TYR A 1 194 ? 41.839 -21.333 -17.850 1.00 27.56 ? 221 TYR A CD2 1 
ATOM   1516 C CE1 . TYR A 1 194 ? 43.614 -23.321 -17.088 1.00 23.79 ? 221 TYR A CE1 1 
ATOM   1517 C CE2 . TYR A 1 194 ? 41.386 -22.432 -17.137 1.00 25.26 ? 221 TYR A CE2 1 
ATOM   1518 C CZ  . TYR A 1 194 ? 42.275 -23.410 -16.745 1.00 25.35 ? 221 TYR A CZ  1 
ATOM   1519 O OH  . TYR A 1 194 ? 41.794 -24.486 -16.073 1.00 30.94 ? 221 TYR A OH  1 
ATOM   1520 N N   . ARG A 1 195 ? 44.546 -16.756 -18.362 1.00 28.27 ? 222 ARG A N   1 
ATOM   1521 C CA  . ARG A 1 195 ? 44.760 -15.477 -19.015 1.00 28.97 ? 222 ARG A CA  1 
ATOM   1522 C C   . ARG A 1 195 ? 45.606 -14.589 -18.110 1.00 28.25 ? 222 ARG A C   1 
ATOM   1523 O O   . ARG A 1 195 ? 45.374 -13.391 -18.037 1.00 27.21 ? 222 ARG A O   1 
ATOM   1524 C CB  . ARG A 1 195 ? 43.452 -14.795 -19.422 1.00 29.10 ? 222 ARG A CB  1 
ATOM   1525 C CG  . ARG A 1 195 ? 42.643 -15.542 -20.479 1.00 31.87 ? 222 ARG A CG  1 
ATOM   1526 C CD  . ARG A 1 195 ? 41.616 -14.601 -21.149 1.00 34.64 ? 222 ARG A CD  1 
ATOM   1527 N NE  . ARG A 1 195 ? 40.715 -15.282 -22.089 1.00 34.41 ? 222 ARG A NE  1 
ATOM   1528 C CZ  . ARG A 1 195 ? 41.054 -15.837 -23.261 1.00 38.73 ? 222 ARG A CZ  1 
ATOM   1529 N NH1 . ARG A 1 195 ? 42.261 -15.663 -23.773 1.00 40.71 ? 222 ARG A NH1 1 
ATOM   1530 N NH2 . ARG A 1 195 ? 40.179 -16.560 -23.932 1.00 35.80 ? 222 ARG A NH2 1 
ATOM   1531 N N   . GLU A 1 196 ? 46.600 -15.200 -17.450 1.00 33.07 ? 223 GLU A N   1 
ATOM   1532 C CA  . GLU A 1 196 ? 47.569 -14.495 -16.617 1.00 35.96 ? 223 GLU A CA  1 
ATOM   1533 C C   . GLU A 1 196 ? 46.919 -13.501 -15.653 1.00 33.53 ? 223 GLU A C   1 
ATOM   1534 O O   . GLU A 1 196 ? 47.547 -12.526 -15.293 1.00 31.77 ? 223 GLU A O   1 
ATOM   1535 C CB  . GLU A 1 196 ? 48.592 -13.749 -17.480 1.00 44.04 ? 223 GLU A CB  1 
ATOM   1536 C CG  . GLU A 1 196 ? 49.420 -14.677 -18.366 1.00 52.74 ? 223 GLU A CG  1 
ATOM   1537 C CD  . GLU A 1 196 ? 50.751 -14.113 -18.845 1.00 65.40 ? 223 GLU A CD  1 
ATOM   1538 O OE1 . GLU A 1 196 ? 51.577 -13.776 -17.971 1.00 76.60 ? 223 GLU A OE1 1 
ATOM   1539 O OE2 . GLU A 1 196 ? 50.980 -14.018 -20.075 1.00 70.45 ? 223 GLU A OE2 1 
ATOM   1540 N N   . GLY A 1 197 ? 45.675 -13.725 -15.214 1.00 30.61 ? 224 GLY A N   1 
ATOM   1541 C CA  . GLY A 1 197 ? 45.098 -12.888 -14.177 1.00 30.17 ? 224 GLY A CA  1 
ATOM   1542 C C   . GLY A 1 197 ? 44.603 -11.544 -14.703 1.00 30.71 ? 224 GLY A C   1 
ATOM   1543 O O   . GLY A 1 197 ? 44.402 -10.619 -13.930 1.00 27.25 ? 224 GLY A O   1 
ATOM   1544 N N   . SER A 1 198 ? 44.391 -11.435 -16.018 1.00 33.16 ? 225 SER A N   1 
ATOM   1545 C CA  . SER A 1 198 ? 43.779 -10.243 -16.588 1.00 33.34 ? 225 SER A CA  1 
ATOM   1546 C C   . SER A 1 198 ? 42.374 -10.033 -16.024 1.00 33.95 ? 225 SER A C   1 
ATOM   1547 O O   . SER A 1 198 ? 41.722 -10.992 -15.635 1.00 33.23 ? 225 SER A O   1 
ATOM   1548 C CB  . SER A 1 198 ? 43.750 -10.319 -18.093 1.00 33.77 ? 225 SER A CB  1 
ATOM   1549 O OG  . SER A 1 198 ? 43.461 -11.641 -18.536 1.00 33.95 ? 225 SER A OG  1 
ATOM   1550 N N   . GLY A 1 199 ? 41.927 -8.768  -16.007 1.00 31.96 ? 226 GLY A N   1 
ATOM   1551 C CA  . GLY A 1 199 ? 40.608 -8.380  -15.522 1.00 34.45 ? 226 GLY A CA  1 
ATOM   1552 C C   . GLY A 1 199 ? 39.470 -8.975  -16.356 1.00 30.93 ? 226 GLY A C   1 
ATOM   1553 O O   . GLY A 1 199 ? 39.636 -9.283  -17.525 1.00 30.75 ? 226 GLY A O   1 
ATOM   1554 N N   . ILE A 1 200 ? 38.318 -9.191  -15.715 1.00 34.55 ? 227 ILE A N   1 
ATOM   1555 C CA  . ILE A 1 200 ? 37.183 -9.807  -16.389 1.00 35.27 ? 227 ILE A CA  1 
ATOM   1556 C C   . ILE A 1 200 ? 36.385 -8.732  -17.119 1.00 35.45 ? 227 ILE A C   1 
ATOM   1557 O O   . ILE A 1 200 ? 35.450 -9.054  -17.849 1.00 36.77 ? 227 ILE A O   1 
ATOM   1558 C CB  . ILE A 1 200 ? 36.271 -10.594 -15.435 1.00 33.06 ? 227 ILE A CB  1 
ATOM   1559 C CG1 . ILE A 1 200 ? 35.736 -9.733  -14.317 1.00 33.32 ? 227 ILE A CG1 1 
ATOM   1560 C CG2 . ILE A 1 200 ? 36.955 -11.855 -14.908 1.00 32.03 ? 227 ILE A CG2 1 
ATOM   1561 C CD1 . ILE A 1 200 ? 34.672 -10.428 -13.482 1.00 36.07 ? 227 ILE A CD1 1 
ATOM   1562 N N   . GLY A 1 201 ? 36.744 -7.465  -16.910 1.00 37.47 ? 228 GLY A N   1 
ATOM   1563 C CA  . GLY A 1 201 ? 36.092 -6.386  -17.636 1.00 43.81 ? 228 GLY A CA  1 
ATOM   1564 C C   . GLY A 1 201 ? 34.637 -6.222  -17.193 1.00 44.82 ? 228 GLY A C   1 
ATOM   1565 O O   . GLY A 1 201 ? 34.213 -6.807  -16.196 1.00 46.41 ? 228 GLY A O   1 
ATOM   1566 N N   . ALA A 1 202 ? 33.885 -5.457  -17.982 1.00 42.66 ? 229 ALA A N   1 
ATOM   1567 C CA  . ALA A 1 202 ? 32.627 -4.881  -17.552 1.00 46.01 ? 229 ALA A CA  1 
ATOM   1568 C C   . ALA A 1 202 ? 31.466 -5.805  -17.887 1.00 40.16 ? 229 ALA A C   1 
ATOM   1569 O O   . ALA A 1 202 ? 31.531 -6.535  -18.861 1.00 38.77 ? 229 ALA A O   1 
ATOM   1570 C CB  . ALA A 1 202 ? 32.438 -3.526  -18.215 1.00 50.87 ? 229 ALA A CB  1 
ATOM   1571 N N   . ILE A 1 203 ? 30.420 -5.751  -17.053 1.00 39.64 ? 230 ILE A N   1 
ATOM   1572 C CA  . ILE A 1 203 ? 29.099 -6.262  -17.388 1.00 39.28 ? 230 ILE A CA  1 
ATOM   1573 C C   . ILE A 1 203 ? 28.392 -5.226  -18.270 1.00 39.45 ? 230 ILE A C   1 
ATOM   1574 O O   . ILE A 1 203 ? 28.413 -4.041  -17.974 1.00 39.65 ? 230 ILE A O   1 
ATOM   1575 C CB  . ILE A 1 203 ? 28.309 -6.563  -16.096 1.00 41.61 ? 230 ILE A CB  1 
ATOM   1576 C CG1 . ILE A 1 203 ? 28.933 -7.706  -15.308 1.00 44.51 ? 230 ILE A CG1 1 
ATOM   1577 C CG2 . ILE A 1 203 ? 26.828 -6.824  -16.366 1.00 41.57 ? 230 ILE A CG2 1 
ATOM   1578 C CD1 . ILE A 1 203 ? 28.934 -9.034  -16.034 1.00 48.37 ? 230 ILE A CD1 1 
ATOM   1579 N N   . ASP A 1 204 ? 27.765 -5.685  -19.356 1.00 36.17 ? 231 ASP A N   1 
ATOM   1580 C CA  . ASP A 1 204 ? 26.990 -4.832  -20.238 1.00 41.43 ? 231 ASP A CA  1 
ATOM   1581 C C   . ASP A 1 204 ? 25.514 -5.106  -19.948 1.00 43.89 ? 231 ASP A C   1 
ATOM   1582 O O   . ASP A 1 204 ? 25.036 -6.245  -20.099 1.00 45.67 ? 231 ASP A O   1 
ATOM   1583 C CB  . ASP A 1 204 ? 27.440 -5.044  -21.678 1.00 43.48 ? 231 ASP A CB  1 
ATOM   1584 C CG  . ASP A 1 204 ? 26.616 -4.386  -22.782 1.00 47.06 ? 231 ASP A CG  1 
ATOM   1585 O OD1 . ASP A 1 204 ? 25.459 -3.979  -22.507 1.00 44.24 ? 231 ASP A OD1 1 
ATOM   1586 O OD2 . ASP A 1 204 ? 27.138 -4.304  -23.925 1.00 42.76 ? 231 ASP A OD2 1 
ATOM   1587 N N   . SER A 1 205 ? 24.806 -4.057  -19.510 1.00 38.95 ? 232 SER A N   1 
ATOM   1588 C CA  . SER A 1 205 ? 23.424 -4.173  -19.065 1.00 44.83 ? 232 SER A CA  1 
ATOM   1589 C C   . SER A 1 205 ? 22.454 -4.471  -20.209 1.00 44.84 ? 232 SER A C   1 
ATOM   1590 O O   . SER A 1 205 ? 21.286 -4.724  -19.952 1.00 50.30 ? 232 SER A O   1 
ATOM   1591 C CB  . SER A 1 205 ? 23.001 -2.925  -18.329 1.00 51.07 ? 232 SER A CB  1 
ATOM   1592 O OG  . SER A 1 205 ? 23.220 -1.780  -19.140 1.00 53.66 ? 232 SER A OG  1 
ATOM   1593 N N   . ASN A 1 206 ? 22.920 -4.443  -21.463 1.00 44.27 ? 233 ASN A N   1 
ATOM   1594 C CA  . ASN A 1 206 ? 22.051 -4.715  -22.595 1.00 46.56 ? 233 ASN A CA  1 
ATOM   1595 C C   . ASN A 1 206 ? 22.394 -6.070  -23.200 1.00 43.49 ? 233 ASN A C   1 
ATOM   1596 O O   . ASN A 1 206 ? 21.962 -6.397  -24.305 1.00 40.50 ? 233 ASN A O   1 
ATOM   1597 C CB  . ASN A 1 206 ? 22.128 -3.595  -23.626 1.00 48.75 ? 233 ASN A CB  1 
ATOM   1598 C CG  . ASN A 1 206 ? 21.786 -2.257  -23.016 1.00 52.66 ? 233 ASN A CG  1 
ATOM   1599 O OD1 . ASN A 1 206 ? 22.592 -1.322  -23.069 1.00 58.86 ? 233 ASN A OD1 1 
ATOM   1600 N ND2 . ASN A 1 206 ? 20.616 -2.155  -22.404 1.00 51.95 ? 233 ASN A ND2 1 
ATOM   1601 N N   . LEU A 1 207 ? 23.190 -6.864  -22.483 1.00 36.91 ? 234 LEU A N   1 
ATOM   1602 C CA  . LEU A 1 207 ? 23.541 -8.173  -23.002 1.00 34.98 ? 234 LEU A CA  1 
ATOM   1603 C C   . LEU A 1 207 ? 22.917 -9.252  -22.123 1.00 30.10 ? 234 LEU A C   1 
ATOM   1604 O O   . LEU A 1 207 ? 22.620 -9.051  -20.952 1.00 34.98 ? 234 LEU A O   1 
ATOM   1605 C CB  . LEU A 1 207 ? 25.054 -8.320  -23.142 1.00 34.39 ? 234 LEU A CB  1 
ATOM   1606 C CG  . LEU A 1 207 ? 25.733 -7.404  -24.168 1.00 38.13 ? 234 LEU A CG  1 
ATOM   1607 C CD1 . LEU A 1 207 ? 27.249 -7.667  -24.218 1.00 40.09 ? 234 LEU A CD1 1 
ATOM   1608 C CD2 . LEU A 1 207 ? 25.125 -7.563  -25.568 1.00 39.03 ? 234 LEU A CD2 1 
ATOM   1609 N N   . ASP A 1 208 ? 22.674 -10.392 -22.749 1.00 31.67 ? 235 ASP A N   1 
ATOM   1610 C CA  . ASP A 1 208 ? 22.180 -11.564 -22.058 1.00 32.13 ? 235 ASP A CA  1 
ATOM   1611 C C   . ASP A 1 208 ? 23.316 -12.193 -21.251 1.00 29.28 ? 235 ASP A C   1 
ATOM   1612 O O   . ASP A 1 208 ? 24.506 -11.946 -21.467 1.00 29.18 ? 235 ASP A O   1 
ATOM   1613 C CB  . ASP A 1 208 ? 21.586 -12.571 -23.025 1.00 30.42 ? 235 ASP A CB  1 
ATOM   1614 C CG  . ASP A 1 208 ? 22.580 -13.126 -24.037 1.00 34.25 ? 235 ASP A CG  1 
ATOM   1615 O OD1 . ASP A 1 208 ? 23.077 -12.321 -24.838 1.00 38.55 ? 235 ASP A OD1 1 
ATOM   1616 O OD2 . ASP A 1 208 ? 22.870 -14.351 -24.006 1.00 32.40 ? 235 ASP A OD2 1 
ATOM   1617 N N   . TRP A 1 209 ? 22.917 -13.068 -20.347 1.00 27.55 ? 236 TRP A N   1 
ATOM   1618 C CA  . TRP A 1 209 ? 23.838 -13.635 -19.373 1.00 28.09 ? 236 TRP A CA  1 
ATOM   1619 C C   . TRP A 1 209 ? 24.974 -14.384 -20.068 1.00 24.20 ? 236 TRP A C   1 
ATOM   1620 O O   . TRP A 1 209 ? 26.130 -14.170 -19.741 1.00 25.86 ? 236 TRP A O   1 
ATOM   1621 C CB  . TRP A 1 209 ? 23.007 -14.530 -18.458 1.00 26.24 ? 236 TRP A CB  1 
ATOM   1622 C CG  . TRP A 1 209 ? 23.615 -15.118 -17.216 1.00 23.55 ? 236 TRP A CG  1 
ATOM   1623 C CD1 . TRP A 1 209 ? 23.979 -14.501 -16.051 1.00 22.93 ? 236 TRP A CD1 1 
ATOM   1624 C CD2 . TRP A 1 209 ? 23.616 -16.522 -16.936 1.00 21.21 ? 236 TRP A CD2 1 
ATOM   1625 N NE1 . TRP A 1 209 ? 24.298 -15.433 -15.105 1.00 20.77 ? 236 TRP A NE1 1 
ATOM   1626 C CE2 . TRP A 1 209 ? 24.073 -16.677 -15.612 1.00 21.72 ? 236 TRP A CE2 1 
ATOM   1627 C CE3 . TRP A 1 209 ? 23.297 -17.649 -17.682 1.00 21.34 ? 236 TRP A CE3 1 
ATOM   1628 C CZ2 . TRP A 1 209 ? 24.231 -17.925 -15.026 1.00 23.13 ? 236 TRP A CZ2 1 
ATOM   1629 C CZ3 . TRP A 1 209 ? 23.434 -18.880 -17.093 1.00 22.91 ? 236 TRP A CZ3 1 
ATOM   1630 C CH2 . TRP A 1 209 ? 23.878 -19.016 -15.776 1.00 22.57 ? 236 TRP A CH2 1 
ATOM   1631 N N   . SER A 1 210 ? 24.646 -15.239 -21.030 1.00 23.49 ? 237 SER A N   1 
ATOM   1632 C CA  . SER A 1 210 ? 25.653 -16.053 -21.682 1.00 25.08 ? 237 SER A CA  1 
ATOM   1633 C C   . SER A 1 210 ? 26.681 -15.178 -22.390 1.00 28.19 ? 237 SER A C   1 
ATOM   1634 O O   . SER A 1 210 ? 27.827 -15.589 -22.567 1.00 24.47 ? 237 SER A O   1 
ATOM   1635 C CB  . SER A 1 210 ? 25.053 -16.984 -22.686 1.00 24.22 ? 237 SER A CB  1 
ATOM   1636 O OG  . SER A 1 210 ? 24.035 -17.795 -22.139 1.00 24.36 ? 237 SER A OG  1 
ATOM   1637 N N   . HIS A 1 211 ? 26.222 -14.038 -22.919 1.00 29.82 ? 238 HIS A N   1 
ATOM   1638 C CA  . HIS A 1 211 ? 27.080 -13.178 -23.721 1.00 33.70 ? 238 HIS A CA  1 
ATOM   1639 C C   . HIS A 1 211 ? 28.037 -12.411 -22.819 1.00 31.89 ? 238 HIS A C   1 
ATOM   1640 O O   . HIS A 1 211 ? 29.226 -12.322 -23.125 1.00 33.07 ? 238 HIS A O   1 
ATOM   1641 C CB  . HIS A 1 211 ? 26.248 -12.232 -24.603 1.00 37.28 ? 238 HIS A CB  1 
ATOM   1642 C CG  . HIS A 1 211 ? 27.040 -11.549 -25.657 1.00 38.47 ? 238 HIS A CG  1 
ATOM   1643 N ND1 . HIS A 1 211 ? 26.492 -10.580 -26.465 1.00 45.44 ? 238 HIS A ND1 1 
ATOM   1644 C CD2 . HIS A 1 211 ? 28.298 -11.706 -26.071 1.00 38.46 ? 238 HIS A CD2 1 
ATOM   1645 C CE1 . HIS A 1 211 ? 27.405 -10.159 -27.323 1.00 40.50 ? 238 HIS A CE1 1 
ATOM   1646 N NE2 . HIS A 1 211 ? 28.508 -10.828 -27.095 1.00 41.69 ? 238 HIS A NE2 1 
ATOM   1647 N N   . ASN A 1 212 ? 27.517 -11.862 -21.715 1.00 28.30 ? 239 ASN A N   1 
ATOM   1648 C CA  . ASN A 1 212 ? 28.376 -11.226 -20.733 1.00 28.84 ? 239 ASN A CA  1 
ATOM   1649 C C   . ASN A 1 212 ? 29.411 -12.234 -20.245 1.00 25.61 ? 239 ASN A C   1 
ATOM   1650 O O   . ASN A 1 212 ? 30.558 -11.886 -20.038 1.00 23.44 ? 239 ASN A O   1 
ATOM   1651 C CB  . ASN A 1 212 ? 27.620 -10.684 -19.532 1.00 29.29 ? 239 ASN A CB  1 
ATOM   1652 C CG  . ASN A 1 212 ? 27.120 -9.283  -19.768 1.00 32.98 ? 239 ASN A CG  1 
ATOM   1653 O OD1 . ASN A 1 212 ? 27.872 -8.425  -20.255 1.00 31.10 ? 239 ASN A OD1 1 
ATOM   1654 N ND2 . ASN A 1 212 ? 25.865 -9.039  -19.420 1.00 32.05 ? 239 ASN A ND2 1 
ATOM   1655 N N   . PHE A 1 213 ? 28.986 -13.484 -20.092 1.00 24.86 ? 240 PHE A N   1 
ATOM   1656 C CA  . PHE A 1 213 ? 29.867 -14.547 -19.654 1.00 23.59 ? 240 PHE A CA  1 
ATOM   1657 C C   . PHE A 1 213 ? 30.979 -14.790 -20.671 1.00 26.73 ? 240 PHE A C   1 
ATOM   1658 O O   . PHE A 1 213 ? 32.136 -14.874 -20.262 1.00 27.94 ? 240 PHE A O   1 
ATOM   1659 C CB  . PHE A 1 213 ? 29.087 -15.832 -19.369 1.00 22.80 ? 240 PHE A CB  1 
ATOM   1660 C CG  . PHE A 1 213 ? 29.908 -16.909 -18.674 1.00 22.77 ? 240 PHE A CG  1 
ATOM   1661 C CD1 . PHE A 1 213 ? 31.032 -16.603 -17.921 1.00 23.35 ? 240 PHE A CD1 1 
ATOM   1662 C CD2 . PHE A 1 213 ? 29.535 -18.236 -18.747 1.00 24.67 ? 240 PHE A CD2 1 
ATOM   1663 C CE1 . PHE A 1 213 ? 31.741 -17.595 -17.275 1.00 22.68 ? 240 PHE A CE1 1 
ATOM   1664 C CE2 . PHE A 1 213 ? 30.262 -19.221 -18.110 1.00 24.98 ? 240 PHE A CE2 1 
ATOM   1665 C CZ  . PHE A 1 213 ? 31.360 -18.896 -17.370 1.00 22.69 ? 240 PHE A CZ  1 
ATOM   1666 N N   . THR A 1 214 ? 30.649 -14.936 -21.966 1.00 22.72 ? 241 THR A N   1 
ATOM   1667 C CA  . THR A 1 214 ? 31.697 -15.271 -22.935 1.00 26.95 ? 241 THR A CA  1 
ATOM   1668 C C   . THR A 1 214 ? 32.657 -14.093 -23.120 1.00 24.06 ? 241 THR A C   1 
ATOM   1669 O O   . THR A 1 214 ? 33.862 -14.291 -23.293 1.00 25.26 ? 241 THR A O   1 
ATOM   1670 C CB  . THR A 1 214 ? 31.132 -15.756 -24.272 1.00 26.57 ? 241 THR A CB  1 
ATOM   1671 O OG1 . THR A 1 214 ? 30.357 -14.718 -24.862 1.00 25.64 ? 241 THR A OG1 1 
ATOM   1672 C CG2 . THR A 1 214 ? 30.361 -17.049 -24.124 1.00 26.05 ? 241 THR A CG2 1 
ATOM   1673 N N   . ASN A 1 215 ? 32.127 -12.873 -22.997 1.00 25.98 ? 242 ASN A N   1 
ATOM   1674 C CA  . ASN A 1 215 ? 32.919 -11.653 -22.985 1.00 25.02 ? 242 ASN A CA  1 
ATOM   1675 C C   . ASN A 1 215 ? 33.905 -11.637 -21.821 1.00 26.35 ? 242 ASN A C   1 
ATOM   1676 O O   . ASN A 1 215 ? 35.057 -11.260 -21.997 1.00 27.67 ? 242 ASN A O   1 
ATOM   1677 C CB  . ASN A 1 215 ? 32.073 -10.392 -22.868 1.00 24.81 ? 242 ASN A CB  1 
ATOM   1678 C CG  . ASN A 1 215 ? 31.479 -9.961  -24.194 1.00 26.59 ? 242 ASN A CG  1 
ATOM   1679 O OD1 . ASN A 1 215 ? 31.763 -10.538 -25.245 1.00 24.44 ? 242 ASN A OD1 1 
ATOM   1680 N ND2 . ASN A 1 215 ? 30.603 -8.975  -24.158 1.00 27.04 ? 242 ASN A ND2 1 
ATOM   1681 N N   . MET A 1 216 ? 33.435 -11.963 -20.610 1.00 26.22 ? 243 MET A N   1 
ATOM   1682 C CA  . MET A 1 216 ? 34.329 -11.994 -19.462 1.00 25.59 ? 243 MET A CA  1 
ATOM   1683 C C   . MET A 1 216 ? 35.327 -13.147 -19.583 1.00 24.08 ? 243 MET A C   1 
ATOM   1684 O O   . MET A 1 216 ? 36.445 -13.035 -19.091 1.00 28.28 ? 243 MET A O   1 
ATOM   1685 C CB  . MET A 1 216 ? 33.558 -12.081 -18.144 1.00 26.50 ? 243 MET A CB  1 
ATOM   1686 C CG  . MET A 1 216 ? 32.649 -10.895 -17.877 1.00 26.42 ? 243 MET A CG  1 
ATOM   1687 S SD  . MET A 1 216 ? 31.977 -10.981 -16.202 1.00 29.02 ? 243 MET A SD  1 
ATOM   1688 C CE  . MET A 1 216 ? 30.694 -12.226 -16.356 1.00 30.57 ? 243 MET A CE  1 
ATOM   1689 N N   . LEU A 1 217 ? 34.940 -14.251 -20.223 1.00 23.75 ? 244 LEU A N   1 
ATOM   1690 C CA  . LEU A 1 217 ? 35.872 -15.342 -20.480 1.00 24.77 ? 244 LEU A CA  1 
ATOM   1691 C C   . LEU A 1 217 ? 36.980 -14.945 -21.458 1.00 27.13 ? 244 LEU A C   1 
ATOM   1692 O O   . LEU A 1 217 ? 38.033 -15.578 -21.444 1.00 25.34 ? 244 LEU A O   1 
ATOM   1693 C CB  . LEU A 1 217 ? 35.158 -16.575 -20.997 1.00 25.95 ? 244 LEU A CB  1 
ATOM   1694 C CG  . LEU A 1 217 ? 34.427 -17.409 -19.946 1.00 28.22 ? 244 LEU A CG  1 
ATOM   1695 C CD1 . LEU A 1 217 ? 33.663 -18.496 -20.678 1.00 27.62 ? 244 LEU A CD1 1 
ATOM   1696 C CD2 . LEU A 1 217 ? 35.434 -17.966 -18.960 1.00 26.78 ? 244 LEU A CD2 1 
ATOM   1697 N N   . GLY A 1 218 ? 36.750 -13.916 -22.290 1.00 30.85 ? 245 GLY A N   1 
ATOM   1698 C CA  . GLY A 1 218 ? 37.766 -13.401 -23.205 1.00 31.31 ? 245 GLY A CA  1 
ATOM   1699 C C   . GLY A 1 218 ? 37.613 -13.947 -24.626 1.00 29.21 ? 245 GLY A C   1 
ATOM   1700 O O   . GLY A 1 218 ? 38.563 -13.897 -25.396 1.00 31.32 ? 245 GLY A O   1 
ATOM   1701 N N   . TYR A 1 219 ? 36.426 -14.485 -24.949 1.00 31.20 ? 246 TYR A N   1 
ATOM   1702 C CA  . TYR A 1 219 ? 36.072 -14.940 -26.284 1.00 34.08 ? 246 TYR A CA  1 
ATOM   1703 C C   . TYR A 1 219 ? 35.214 -13.878 -26.973 1.00 36.86 ? 246 TYR A C   1 
ATOM   1704 O O   . TYR A 1 219 ? 34.553 -13.097 -26.290 1.00 42.80 ? 246 TYR A O   1 
ATOM   1705 C CB  . TYR A 1 219 ? 35.311 -16.259 -26.164 1.00 35.74 ? 246 TYR A CB  1 
ATOM   1706 C CG  . TYR A 1 219 ? 36.194 -17.387 -25.669 1.00 41.34 ? 246 TYR A CG  1 
ATOM   1707 C CD1 . TYR A 1 219 ? 36.397 -17.590 -24.313 1.00 34.90 ? 246 TYR A CD1 1 
ATOM   1708 C CD2 . TYR A 1 219 ? 36.870 -18.206 -26.561 1.00 43.10 ? 246 TYR A CD2 1 
ATOM   1709 C CE1 . TYR A 1 219 ? 37.224 -18.597 -23.855 1.00 35.85 ? 246 TYR A CE1 1 
ATOM   1710 C CE2 . TYR A 1 219 ? 37.687 -19.231 -26.113 1.00 50.39 ? 246 TYR A CE2 1 
ATOM   1711 C CZ  . TYR A 1 219 ? 37.862 -19.427 -24.754 1.00 40.62 ? 246 TYR A CZ  1 
ATOM   1712 O OH  . TYR A 1 219 ? 38.685 -20.414 -24.318 1.00 39.46 ? 246 TYR A OH  1 
ATOM   1713 N N   . THR A 1 220 ? 35.239 -13.836 -28.314 1.00 37.60 ? 247 THR A N   1 
ATOM   1714 C CA  . THR A 1 220 ? 34.374 -12.929 -29.069 1.00 38.85 ? 247 THR A CA  1 
ATOM   1715 C C   . THR A 1 220 ? 33.581 -13.661 -30.153 1.00 33.26 ? 247 THR A C   1 
ATOM   1716 O O   . THR A 1 220 ? 32.613 -13.125 -30.670 1.00 38.10 ? 247 THR A O   1 
ATOM   1717 C CB  . THR A 1 220 ? 35.198 -11.802 -29.686 1.00 44.66 ? 247 THR A CB  1 
ATOM   1718 O OG1 . THR A 1 220 ? 36.068 -12.508 -30.563 1.00 47.46 ? 247 THR A OG1 1 
ATOM   1719 C CG2 . THR A 1 220 ? 35.939 -10.969 -28.653 1.00 46.16 ? 247 THR A CG2 1 
ATOM   1720 N N   . ASP A 1 221 ? 33.982 -14.872 -30.524 1.00 33.37 ? 248 ASP A N   1 
ATOM   1721 C CA  . ASP A 1 221 ? 33.300 -15.605 -31.570 1.00 34.33 ? 248 ASP A CA  1 
ATOM   1722 C C   . ASP A 1 221 ? 31.806 -15.711 -31.234 1.00 38.41 ? 248 ASP A C   1 
ATOM   1723 O O   . ASP A 1 221 ? 31.417 -16.340 -30.245 1.00 34.71 ? 248 ASP A O   1 
ATOM   1724 C CB  . ASP A 1 221 ? 33.988 -16.944 -31.783 1.00 34.92 ? 248 ASP A CB  1 
ATOM   1725 C CG  . ASP A 1 221 ? 33.414 -17.831 -32.880 1.00 40.71 ? 248 ASP A CG  1 
ATOM   1726 O OD1 . ASP A 1 221 ? 32.178 -17.895 -33.004 1.00 44.35 ? 248 ASP A OD1 1 
ATOM   1727 O OD2 . ASP A 1 221 ? 34.207 -18.496 -33.582 1.00 46.27 ? 248 ASP A OD2 1 
ATOM   1728 N N   . HIS A 1 222 ? 30.962 -15.145 -32.110 1.00 37.48 ? 249 HIS A N   1 
ATOM   1729 C CA  . HIS A 1 222 ? 29.514 -15.168 -31.956 1.00 35.76 ? 249 HIS A CA  1 
ATOM   1730 C C   . HIS A 1 222 ? 28.999 -16.596 -31.779 1.00 34.05 ? 249 HIS A C   1 
ATOM   1731 O O   . HIS A 1 222 ? 28.082 -16.803 -30.993 1.00 35.56 ? 249 HIS A O   1 
ATOM   1732 C CB  . HIS A 1 222 ? 28.826 -14.488 -33.149 1.00 43.06 ? 249 HIS A CB  1 
ATOM   1733 C CG  . HIS A 1 222 ? 27.340 -14.699 -33.237 1.00 46.65 ? 249 HIS A CG  1 
ATOM   1734 N ND1 . HIS A 1 222 ? 26.777 -15.802 -33.850 1.00 50.39 ? 249 HIS A ND1 1 
ATOM   1735 C CD2 . HIS A 1 222 ? 26.302 -13.961 -32.806 1.00 47.34 ? 249 HIS A CD2 1 
ATOM   1736 C CE1 . HIS A 1 222 ? 25.444 -15.727 -33.789 1.00 44.92 ? 249 HIS A CE1 1 
ATOM   1737 N NE2 . HIS A 1 222 ? 25.136 -14.623 -33.148 1.00 46.83 ? 249 HIS A NE2 1 
ATOM   1738 N N   . GLN A 1 223 ? 29.573 -17.581 -32.489 1.00 29.86 ? 250 GLN A N   1 
ATOM   1739 C CA  . GLN A 1 223 ? 29.026 -18.924 -32.444 1.00 34.76 ? 250 GLN A CA  1 
ATOM   1740 C C   . GLN A 1 223 ? 29.434 -19.617 -31.146 1.00 32.99 ? 250 GLN A C   1 
ATOM   1741 O O   . GLN A 1 223 ? 28.859 -20.634 -30.790 1.00 28.13 ? 250 GLN A O   1 
ATOM   1742 C CB  . GLN A 1 223 ? 29.376 -19.796 -33.649 1.00 40.71 ? 250 GLN A CB  1 
ATOM   1743 C CG  . GLN A 1 223 ? 28.539 -19.493 -34.889 1.00 45.06 ? 250 GLN A CG  1 
ATOM   1744 C CD  . GLN A 1 223 ? 27.078 -19.870 -34.731 1.00 50.93 ? 250 GLN A CD  1 
ATOM   1745 O OE1 . GLN A 1 223 ? 26.746 -21.000 -34.353 1.00 61.73 ? 250 GLN A OE1 1 
ATOM   1746 N NE2 . GLN A 1 223 ? 26.183 -18.934 -35.007 1.00 49.68 ? 250 GLN A NE2 1 
ATOM   1747 N N   . PHE A 1 224 ? 30.422 -19.067 -30.447 1.00 33.82 ? 251 PHE A N   1 
ATOM   1748 C CA  . PHE A 1 224 ? 30.798 -19.632 -29.165 1.00 33.51 ? 251 PHE A CA  1 
ATOM   1749 C C   . PHE A 1 224 ? 29.745 -19.219 -28.141 1.00 27.78 ? 251 PHE A C   1 
ATOM   1750 O O   . PHE A 1 224 ? 29.331 -20.036 -27.333 1.00 25.72 ? 251 PHE A O   1 
ATOM   1751 C CB  . PHE A 1 224 ? 32.225 -19.248 -28.763 1.00 30.48 ? 251 PHE A CB  1 
ATOM   1752 C CG  . PHE A 1 224 ? 32.584 -19.835 -27.407 1.00 30.04 ? 251 PHE A CG  1 
ATOM   1753 C CD1 . PHE A 1 224 ? 32.660 -21.216 -27.230 1.00 32.32 ? 251 PHE A CD1 1 
ATOM   1754 C CD2 . PHE A 1 224 ? 32.781 -19.016 -26.304 1.00 31.00 ? 251 PHE A CD2 1 
ATOM   1755 C CE1 . PHE A 1 224 ? 32.958 -21.753 -25.980 1.00 31.93 ? 251 PHE A CE1 1 
ATOM   1756 C CE2 . PHE A 1 224 ? 33.129 -19.557 -25.067 1.00 31.25 ? 251 PHE A CE2 1 
ATOM   1757 C CZ  . PHE A 1 224 ? 33.193 -20.917 -24.910 1.00 30.06 ? 251 PHE A CZ  1 
ATOM   1758 N N   . THR A 1 225 ? 29.358 -17.937 -28.184 1.00 24.92 ? 252 THR A N   1 
ATOM   1759 C CA  . THR A 1 225 ? 28.272 -17.404 -27.394 1.00 26.07 ? 252 THR A CA  1 
ATOM   1760 C C   . THR A 1 225 ? 27.006 -18.200 -27.650 1.00 25.69 ? 252 THR A C   1 
ATOM   1761 O O   . THR A 1 225 ? 26.286 -18.500 -26.708 1.00 28.18 ? 252 THR A O   1 
ATOM   1762 C CB  . THR A 1 225 ? 28.096 -15.924 -27.707 1.00 28.17 ? 252 THR A CB  1 
ATOM   1763 O OG1 . THR A 1 225 ? 29.355 -15.373 -27.337 1.00 27.15 ? 252 THR A OG1 1 
ATOM   1764 C CG2 . THR A 1 225 ? 27.017 -15.268 -26.869 1.00 28.40 ? 252 THR A CG2 1 
ATOM   1765 N N   . GLU A 1 226 ? 26.759 -18.569 -28.912 1.00 24.25 ? 253 GLU A N   1 
ATOM   1766 C CA  . GLU A 1 226 ? 25.584 -19.343 -29.240 1.00 24.76 ? 253 GLU A CA  1 
ATOM   1767 C C   . GLU A 1 226 ? 25.697 -20.720 -28.597 1.00 26.01 ? 253 GLU A C   1 
ATOM   1768 O O   . GLU A 1 226 ? 24.729 -21.229 -28.032 1.00 21.94 ? 253 GLU A O   1 
ATOM   1769 C CB  . GLU A 1 226 ? 25.393 -19.421 -30.758 1.00 25.50 ? 253 GLU A CB  1 
ATOM   1770 C CG  . GLU A 1 226 ? 24.749 -18.154 -31.313 1.00 27.93 ? 253 GLU A CG  1 
ATOM   1771 C CD  . GLU A 1 226 ? 23.245 -18.158 -31.085 1.00 27.68 ? 253 GLU A CD  1 
ATOM   1772 O OE1 . GLU A 1 226 ? 22.579 -18.896 -31.822 1.00 30.52 ? 253 GLU A OE1 1 
ATOM   1773 O OE2 . GLU A 1 226 ? 22.736 -17.549 -30.122 1.00 31.62 ? 253 GLU A OE2 1 
ATOM   1774 N N   . LEU A 1 227 ? 26.883 -21.328 -28.689 1.00 26.09 ? 254 LEU A N   1 
ATOM   1775 C CA  . LEU A 1 227 ? 27.069 -22.638 -28.084 1.00 27.97 ? 254 LEU A CA  1 
ATOM   1776 C C   . LEU A 1 227 ? 26.865 -22.558 -26.571 1.00 25.58 ? 254 LEU A C   1 
ATOM   1777 O O   . LEU A 1 227 ? 26.280 -23.461 -25.971 1.00 31.91 ? 254 LEU A O   1 
ATOM   1778 C CB  . LEU A 1 227 ? 28.455 -23.187 -28.395 1.00 26.08 ? 254 LEU A CB  1 
ATOM   1779 C CG  . LEU A 1 227 ? 28.852 -24.452 -27.636 1.00 23.99 ? 254 LEU A CG  1 
ATOM   1780 C CD1 . LEU A 1 227 ? 28.061 -25.673 -28.012 1.00 26.33 ? 254 LEU A CD1 1 
ATOM   1781 C CD2 . LEU A 1 227 ? 30.326 -24.682 -27.891 1.00 25.09 ? 254 LEU A CD2 1 
ATOM   1782 N N   . THR A 1 228 ? 27.354 -21.477 -25.974 1.00 25.04 ? 255 THR A N   1 
ATOM   1783 C CA  . THR A 1 228 ? 27.264 -21.290 -24.536 1.00 25.34 ? 255 THR A CA  1 
ATOM   1784 C C   . THR A 1 228 ? 25.805 -21.170 -24.091 1.00 23.77 ? 255 THR A C   1 
ATOM   1785 O O   . THR A 1 228 ? 25.450 -21.685 -23.046 1.00 23.67 ? 255 THR A O   1 
ATOM   1786 C CB  . THR A 1 228 ? 28.074 -20.061 -24.158 1.00 23.46 ? 255 THR A CB  1 
ATOM   1787 O OG1 . THR A 1 228 ? 29.417 -20.402 -24.464 1.00 23.47 ? 255 THR A OG1 1 
ATOM   1788 C CG2 . THR A 1 228 ? 28.038 -19.791 -22.666 1.00 25.14 ? 255 THR A CG2 1 
ATOM   1789 N N   . ARG A 1 229 ? 24.982 -20.449 -24.864 1.00 24.75 ? 256 ARG A N   1 
ATOM   1790 C CA  . ARG A 1 229 ? 23.561 -20.304 -24.602 1.00 23.99 ? 256 ARG A CA  1 
ATOM   1791 C C   . ARG A 1 229 ? 22.909 -21.672 -24.588 1.00 22.67 ? 256 ARG A C   1 
ATOM   1792 O O   . ARG A 1 229 ? 22.136 -21.979 -23.687 1.00 26.16 ? 256 ARG A O   1 
ATOM   1793 C CB  . ARG A 1 229 ? 22.891 -19.424 -25.659 1.00 26.26 ? 256 ARG A CB  1 
ATOM   1794 C CG  . ARG A 1 229 ? 23.312 -17.968 -25.583 1.00 25.91 ? 256 ARG A CG  1 
ATOM   1795 C CD  . ARG A 1 229 ? 22.936 -17.188 -26.836 1.00 26.94 ? 256 ARG A CD  1 
ATOM   1796 N NE  . ARG A 1 229 ? 23.203 -15.755 -26.635 1.00 26.25 ? 256 ARG A NE  1 
ATOM   1797 C CZ  . ARG A 1 229 ? 23.717 -14.923 -27.525 1.00 27.82 ? 256 ARG A CZ  1 
ATOM   1798 N NH1 . ARG A 1 229 ? 24.049 -15.367 -28.728 1.00 32.21 ? 256 ARG A NH1 1 
ATOM   1799 N NH2 . ARG A 1 229 ? 23.854 -13.644 -27.235 1.00 26.12 ? 256 ARG A NH2 1 
ATOM   1800 N N   . LEU A 1 230 ? 23.257 -22.497 -25.570 1.00 24.61 ? 257 LEU A N   1 
ATOM   1801 C CA  . LEU A 1 230 ? 22.707 -23.840 -25.692 1.00 26.96 ? 257 LEU A CA  1 
ATOM   1802 C C   . LEU A 1 230 ? 23.153 -24.687 -24.509 1.00 25.57 ? 257 LEU A C   1 
ATOM   1803 O O   . LEU A 1 230 ? 22.351 -25.379 -23.885 1.00 28.45 ? 257 LEU A O   1 
ATOM   1804 C CB  . LEU A 1 230 ? 23.116 -24.494 -27.015 1.00 27.16 ? 257 LEU A CB  1 
ATOM   1805 C CG  . LEU A 1 230 ? 22.601 -25.920 -27.245 1.00 29.22 ? 257 LEU A CG  1 
ATOM   1806 C CD1 . LEU A 1 230 ? 21.079 -25.945 -27.319 1.00 29.08 ? 257 LEU A CD1 1 
ATOM   1807 C CD2 . LEU A 1 230 ? 23.159 -26.544 -28.510 1.00 31.32 ? 257 LEU A CD2 1 
ATOM   1808 N N   . TYR A 1 231 ? 24.464 -24.667 -24.265 1.00 25.56 ? 258 TYR A N   1 
ATOM   1809 C CA  . TYR A 1 231 ? 25.086 -25.453 -23.214 1.00 23.46 ? 258 TYR A CA  1 
ATOM   1810 C C   . TYR A 1 231 ? 24.495 -25.143 -21.831 1.00 22.44 ? 258 TYR A C   1 
ATOM   1811 O O   . TYR A 1 231 ? 24.208 -26.033 -21.033 1.00 23.05 ? 258 TYR A O   1 
ATOM   1812 C CB  . TYR A 1 231 ? 26.582 -25.108 -23.286 1.00 24.52 ? 258 TYR A CB  1 
ATOM   1813 C CG  . TYR A 1 231 ? 27.377 -25.880 -22.253 1.00 25.19 ? 258 TYR A CG  1 
ATOM   1814 C CD1 . TYR A 1 231 ? 27.308 -25.464 -20.929 1.00 26.21 ? 258 TYR A CD1 1 
ATOM   1815 C CD2 . TYR A 1 231 ? 28.141 -27.007 -22.562 1.00 24.72 ? 258 TYR A CD2 1 
ATOM   1816 C CE1 . TYR A 1 231 ? 27.993 -26.119 -19.934 1.00 28.09 ? 258 TYR A CE1 1 
ATOM   1817 C CE2 . TYR A 1 231 ? 28.828 -27.683 -21.556 1.00 26.66 ? 258 TYR A CE2 1 
ATOM   1818 C CZ  . TYR A 1 231 ? 28.733 -27.241 -20.239 1.00 25.38 ? 258 TYR A CZ  1 
ATOM   1819 O OH  . TYR A 1 231 ? 29.338 -27.759 -19.125 1.00 24.22 ? 258 TYR A OH  1 
ATOM   1820 N N   . LEU A 1 232 ? 24.338 -23.855 -21.549 1.00 24.28 ? 259 LEU A N   1 
ATOM   1821 C CA  . LEU A 1 232 ? 23.855 -23.392 -20.270 1.00 23.18 ? 259 LEU A CA  1 
ATOM   1822 C C   . LEU A 1 232 ? 22.370 -23.735 -20.129 1.00 23.50 ? 259 LEU A C   1 
ATOM   1823 O O   . LEU A 1 232 ? 21.888 -23.974 -19.024 1.00 20.22 ? 259 LEU A O   1 
ATOM   1824 C CB  . LEU A 1 232 ? 24.133 -21.903 -20.124 1.00 22.57 ? 259 LEU A CB  1 
ATOM   1825 C CG  . LEU A 1 232 ? 25.610 -21.515 -20.030 1.00 24.60 ? 259 LEU A CG  1 
ATOM   1826 C CD1 . LEU A 1 232 ? 25.682 -20.016 -19.829 1.00 25.56 ? 259 LEU A CD1 1 
ATOM   1827 C CD2 . LEU A 1 232 ? 26.360 -22.218 -18.911 1.00 26.61 ? 259 LEU A CD2 1 
ATOM   1828 N N   . THR A 1 233 ? 21.657 -23.806 -21.248 1.00 25.67 ? 260 THR A N   1 
ATOM   1829 C CA  . THR A 1 233 ? 20.244 -24.136 -21.212 1.00 24.33 ? 260 THR A CA  1 
ATOM   1830 C C   . THR A 1 233 ? 20.101 -25.623 -20.909 1.00 21.96 ? 260 THR A C   1 
ATOM   1831 O O   . THR A 1 233 ? 19.334 -26.000 -20.045 1.00 22.53 ? 260 THR A O   1 
ATOM   1832 C CB  . THR A 1 233 ? 19.572 -23.763 -22.536 1.00 24.58 ? 260 THR A CB  1 
ATOM   1833 O OG1 . THR A 1 233 ? 19.558 -22.349 -22.661 1.00 24.02 ? 260 THR A OG1 1 
ATOM   1834 C CG2 . THR A 1 233 ? 18.118 -24.188 -22.586 1.00 28.36 ? 260 THR A CG2 1 
ATOM   1835 N N   . ILE A 1 234 ? 20.826 -26.488 -21.618 1.00 23.25 ? 261 ILE A N   1 
ATOM   1836 C CA  . ILE A 1 234 ? 20.522 -27.918 -21.548 1.00 22.53 ? 261 ILE A CA  1 
ATOM   1837 C C   . ILE A 1 234 ? 21.124 -28.646 -20.342 1.00 23.07 ? 261 ILE A C   1 
ATOM   1838 O O   . ILE A 1 234 ? 20.674 -29.761 -20.018 1.00 23.75 ? 261 ILE A O   1 
ATOM   1839 C CB  . ILE A 1 234 ? 20.941 -28.613 -22.851 1.00 23.93 ? 261 ILE A CB  1 
ATOM   1840 C CG1 . ILE A 1 234 ? 22.467 -28.652 -23.004 1.00 25.30 ? 261 ILE A CG1 1 
ATOM   1841 C CG2 . ILE A 1 234 ? 20.250 -27.920 -24.020 1.00 25.00 ? 261 ILE A CG2 1 
ATOM   1842 C CD1 . ILE A 1 234 ? 22.935 -29.316 -24.282 1.00 28.10 ? 261 ILE A CD1 1 
ATOM   1843 N N   . HIS A 1 235 ? 22.184 -28.102 -19.736 1.00 20.99 ? 262 HIS A N   1 
ATOM   1844 C CA  . HIS A 1 235 ? 22.735 -28.666 -18.505 1.00 22.92 ? 262 HIS A CA  1 
ATOM   1845 C C   . HIS A 1 235 ? 22.057 -28.144 -17.228 1.00 24.65 ? 262 HIS A C   1 
ATOM   1846 O O   . HIS A 1 235 ? 22.457 -28.516 -16.112 1.00 24.83 ? 262 HIS A O   1 
ATOM   1847 C CB  . HIS A 1 235 ? 24.238 -28.370 -18.380 1.00 22.35 ? 262 HIS A CB  1 
ATOM   1848 C CG  . HIS A 1 235 ? 25.098 -29.070 -19.371 1.00 23.13 ? 262 HIS A CG  1 
ATOM   1849 N ND1 . HIS A 1 235 ? 25.315 -28.578 -20.633 1.00 20.40 ? 262 HIS A ND1 1 
ATOM   1850 C CD2 . HIS A 1 235 ? 25.845 -30.184 -19.262 1.00 23.37 ? 262 HIS A CD2 1 
ATOM   1851 C CE1 . HIS A 1 235 ? 26.147 -29.399 -21.261 1.00 24.23 ? 262 HIS A CE1 1 
ATOM   1852 N NE2 . HIS A 1 235 ? 26.466 -30.387 -20.449 1.00 24.13 ? 262 HIS A NE2 1 
ATOM   1853 N N   . SER A 1 236 ? 20.978 -27.368 -17.373 1.00 25.37 ? 263 SER A N   1 
ATOM   1854 C CA  . SER A 1 236 ? 20.451 -26.542 -16.297 1.00 25.25 ? 263 SER A CA  1 
ATOM   1855 C C   . SER A 1 236 ? 19.822 -27.351 -15.163 1.00 23.42 ? 263 SER A C   1 
ATOM   1856 O O   . SER A 1 236 ? 19.831 -26.904 -14.014 1.00 26.09 ? 263 SER A O   1 
ATOM   1857 C CB  . SER A 1 236 ? 19.436 -25.582 -16.849 1.00 26.97 ? 263 SER A CB  1 
ATOM   1858 O OG  . SER A 1 236 ? 18.365 -26.300 -17.446 1.00 23.66 ? 263 SER A OG  1 
ATOM   1859 N N   . ASP A 1 237 ? 19.256 -28.515 -15.499 1.00 23.57 ? 264 ASP A N   1 
ATOM   1860 C CA  . ASP A 1 237 ? 18.461 -29.317 -14.581 1.00 24.05 ? 264 ASP A CA  1 
ATOM   1861 C C   . ASP A 1 237 ? 18.352 -30.722 -15.158 1.00 21.45 ? 264 ASP A C   1 
ATOM   1862 O O   . ASP A 1 237 ? 18.203 -30.892 -16.372 1.00 22.92 ? 264 ASP A O   1 
ATOM   1863 C CB  . ASP A 1 237 ? 17.070 -28.706 -14.334 1.00 25.06 ? 264 ASP A CB  1 
ATOM   1864 C CG  . ASP A 1 237 ? 16.455 -28.882 -12.932 1.00 25.43 ? 264 ASP A CG  1 
ATOM   1865 O OD1 . ASP A 1 237 ? 17.198 -28.818 -11.941 1.00 23.01 ? 264 ASP A OD1 1 
ATOM   1866 O OD2 . ASP A 1 237 ? 15.191 -28.975 -12.814 1.00 30.84 ? 264 ASP A OD2 1 
ATOM   1867 N N   . HIS A 1 238 ? 18.429 -31.729 -14.290 1.00 23.26 ? 265 HIS A N   1 
ATOM   1868 C CA  . HIS A 1 238 ? 18.258 -33.116 -14.698 1.00 28.73 ? 265 HIS A CA  1 
ATOM   1869 C C   . HIS A 1 238 ? 17.561 -33.864 -13.568 1.00 27.13 ? 265 HIS A C   1 
ATOM   1870 O O   . HIS A 1 238 ? 18.042 -34.890 -13.081 1.00 26.86 ? 265 HIS A O   1 
ATOM   1871 C CB  . HIS A 1 238 ? 19.587 -33.725 -15.168 1.00 30.36 ? 265 HIS A CB  1 
ATOM   1872 C CG  . HIS A 1 238 ? 19.429 -34.791 -16.203 1.00 34.27 ? 265 HIS A CG  1 
ATOM   1873 N ND1 . HIS A 1 238 ? 18.757 -34.554 -17.381 1.00 34.72 ? 265 HIS A ND1 1 
ATOM   1874 C CD2 . HIS A 1 238 ? 19.891 -36.058 -16.278 1.00 32.34 ? 265 HIS A CD2 1 
ATOM   1875 C CE1 . HIS A 1 238 ? 18.784 -35.650 -18.121 1.00 36.25 ? 265 HIS A CE1 1 
ATOM   1876 N NE2 . HIS A 1 238 ? 19.472 -36.578 -17.474 1.00 39.11 ? 265 HIS A NE2 1 
ATOM   1877 N N   . GLU A 1 239 ? 16.399 -33.346 -13.212 1.00 26.54 ? 266 GLU A N   1 
ATOM   1878 C CA  . GLU A 1 239 ? 15.590 -33.933 -12.118 1.00 26.83 ? 266 GLU A CA  1 
ATOM   1879 C C   . GLU A 1 239 ? 16.291 -33.693 -10.775 1.00 26.21 ? 266 GLU A C   1 
ATOM   1880 O O   . GLU A 1 239 ? 17.280 -32.962 -10.727 1.00 27.93 ? 266 GLU A O   1 
ATOM   1881 C CB  . GLU A 1 239 ? 15.040 -35.331 -12.449 1.00 27.28 ? 266 GLU A CB  1 
ATOM   1882 C CG  . GLU A 1 239 ? 15.767 -36.547 -11.889 1.00 29.54 ? 266 GLU A CG  1 
ATOM   1883 C CD  . GLU A 1 239 ? 14.835 -37.744 -11.916 1.00 33.42 ? 266 GLU A CD  1 
ATOM   1884 O OE1 . GLU A 1 239 ? 13.892 -37.759 -12.735 1.00 31.49 ? 266 GLU A OE1 1 
ATOM   1885 O OE2 . GLU A 1 239 ? 15.047 -38.656 -11.100 1.00 37.05 ? 266 GLU A OE2 1 
ATOM   1886 N N   . GLY A 1 240 ? 15.803 -34.332 -9.736  1.00 23.47 ? 267 GLY A N   1 
ATOM   1887 C CA  . GLY A 1 240 ? 16.215 -34.004 -8.391  1.00 23.68 ? 267 GLY A CA  1 
ATOM   1888 C C   . GLY A 1 240 ? 17.155 -35.046 -7.804  1.00 24.76 ? 267 GLY A C   1 
ATOM   1889 O O   . GLY A 1 240 ? 17.785 -34.759 -6.788  1.00 27.39 ? 267 GLY A O   1 
ATOM   1890 N N   . GLY A 1 241 ? 17.251 -36.222 -8.447  1.00 24.13 ? 268 GLY A N   1 
ATOM   1891 C CA  . GLY A 1 241 ? 18.008 -37.339 -7.895  1.00 22.24 ? 268 GLY A CA  1 
ATOM   1892 C C   . GLY A 1 241 ? 19.496 -37.350 -8.253  1.00 24.29 ? 268 GLY A C   1 
ATOM   1893 O O   . GLY A 1 241 ? 20.260 -38.125 -7.681  1.00 21.70 ? 268 GLY A O   1 
ATOM   1894 N N   . ASN A 1 242 ? 19.941 -36.508 -9.197  1.00 25.41 ? 269 ASN A N   1 
ATOM   1895 C CA  . ASN A 1 242 ? 21.372 -36.453 -9.483  1.00 22.98 ? 269 ASN A CA  1 
ATOM   1896 C C   . ASN A 1 242 ? 22.078 -35.846 -8.271  1.00 20.89 ? 269 ASN A C   1 
ATOM   1897 O O   . ASN A 1 242 ? 21.462 -35.177 -7.466  1.00 24.34 ? 269 ASN A O   1 
ATOM   1898 C CB  . ASN A 1 242 ? 21.638 -35.777 -10.824 1.00 22.11 ? 269 ASN A CB  1 
ATOM   1899 C CG  . ASN A 1 242 ? 21.422 -34.282 -10.809 1.00 23.18 ? 269 ASN A CG  1 
ATOM   1900 O OD1 . ASN A 1 242 ? 22.269 -33.552 -10.304 1.00 25.50 ? 269 ASN A OD1 1 
ATOM   1901 N ND2 . ASN A 1 242 ? 20.356 -33.794 -11.422 1.00 22.25 ? 269 ASN A ND2 1 
ATOM   1902 N N   . VAL A 1 243 ? 23.388 -36.038 -8.160  1.00 23.12 ? 270 VAL A N   1 
ATOM   1903 C CA  . VAL A 1 243 ? 24.096 -35.699 -6.939  1.00 23.31 ? 270 VAL A CA  1 
ATOM   1904 C C   . VAL A 1 243 ? 24.082 -34.193 -6.662  1.00 20.10 ? 270 VAL A C   1 
ATOM   1905 O O   . VAL A 1 243 ? 24.059 -33.822 -5.497  1.00 19.21 ? 270 VAL A O   1 
ATOM   1906 C CB  . VAL A 1 243 ? 25.527 -36.278 -6.970  1.00 23.64 ? 270 VAL A CB  1 
ATOM   1907 C CG1 . VAL A 1 243 ? 26.407 -35.704 -5.863  1.00 22.73 ? 270 VAL A CG1 1 
ATOM   1908 C CG2 . VAL A 1 243 ? 25.472 -37.802 -6.892  1.00 25.18 ? 270 VAL A CG2 1 
ATOM   1909 N N   . SER A 1 244 ? 24.129 -33.348 -7.690  1.00 18.13 ? 271 SER A N   1 
ATOM   1910 C CA  . SER A 1 244 ? 24.237 -31.910 -7.451  1.00 20.74 ? 271 SER A CA  1 
ATOM   1911 C C   . SER A 1 244 ? 22.861 -31.318 -7.117  1.00 19.16 ? 271 SER A C   1 
ATOM   1912 O O   . SER A 1 244 ? 22.706 -30.577 -6.157  1.00 19.51 ? 271 SER A O   1 
ATOM   1913 C CB  . SER A 1 244 ? 24.908 -31.169 -8.593  1.00 20.27 ? 271 SER A CB  1 
ATOM   1914 O OG  . SER A 1 244 ? 24.299 -31.397 -9.860  1.00 22.11 ? 271 SER A OG  1 
ATOM   1915 N N   . ALA A 1 245 ? 21.834 -31.722 -7.847  1.00 18.04 ? 272 ALA A N   1 
ATOM   1916 C CA  . ALA A 1 245 ? 20.489 -31.339 -7.450  1.00 19.85 ? 272 ALA A CA  1 
ATOM   1917 C C   . ALA A 1 245 ? 20.175 -31.869 -6.052  1.00 20.03 ? 272 ALA A C   1 
ATOM   1918 O O   . ALA A 1 245 ? 19.710 -31.130 -5.201  1.00 21.60 ? 272 ALA A O   1 
ATOM   1919 C CB  . ALA A 1 245 ? 19.480 -31.808 -8.474  1.00 20.00 ? 272 ALA A CB  1 
ATOM   1920 N N   . HIS A 1 246 ? 20.458 -33.139 -5.774  1.00 19.35 ? 273 HIS A N   1 
ATOM   1921 C CA  . HIS A 1 246 ? 20.086 -33.693 -4.485  1.00 19.38 ? 273 HIS A CA  1 
ATOM   1922 C C   . HIS A 1 246 ? 20.853 -33.049 -3.330  1.00 19.25 ? 273 HIS A C   1 
ATOM   1923 O O   . HIS A 1 246 ? 20.340 -32.859 -2.206  1.00 19.87 ? 273 HIS A O   1 
ATOM   1924 C CB  . HIS A 1 246 ? 20.293 -35.206 -4.535  1.00 19.63 ? 273 HIS A CB  1 
ATOM   1925 C CG  . HIS A 1 246 ? 19.741 -35.940 -3.389  1.00 21.67 ? 273 HIS A CG  1 
ATOM   1926 N ND1 . HIS A 1 246 ? 20.104 -37.247 -3.168  1.00 20.98 ? 273 HIS A ND1 1 
ATOM   1927 C CD2 . HIS A 1 246 ? 18.878 -35.613 -2.404  1.00 23.93 ? 273 HIS A CD2 1 
ATOM   1928 C CE1 . HIS A 1 246 ? 19.490 -37.684 -2.085  1.00 23.14 ? 273 HIS A CE1 1 
ATOM   1929 N NE2 . HIS A 1 246 ? 18.772 -36.710 -1.587  1.00 23.55 ? 273 HIS A NE2 1 
ATOM   1930 N N   . THR A 1 247 ? 22.128 -32.768 -3.575  1.00 20.30 ? 274 THR A N   1 
ATOM   1931 C CA  . THR A 1 247 ? 22.937 -32.133 -2.558  1.00 19.67 ? 274 THR A CA  1 
ATOM   1932 C C   . THR A 1 247 ? 22.374 -30.743 -2.308  1.00 18.91 ? 274 THR A C   1 
ATOM   1933 O O   . THR A 1 247 ? 22.180 -30.372 -1.158  1.00 19.04 ? 274 THR A O   1 
ATOM   1934 C CB  . THR A 1 247 ? 24.400 -32.101 -2.962  1.00 20.99 ? 274 THR A CB  1 
ATOM   1935 O OG1 . THR A 1 247 ? 24.753 -33.485 -3.068  1.00 20.08 ? 274 THR A OG1 1 
ATOM   1936 C CG2 . THR A 1 247 ? 25.235 -31.333 -1.949  1.00 19.38 ? 274 THR A CG2 1 
ATOM   1937 N N   . SER A 1 248 ? 22.068 -30.000 -3.375  1.00 19.11 ? 275 SER A N   1 
ATOM   1938 C CA  . SER A 1 248 ? 21.535 -28.664 -3.170  1.00 20.02 ? 275 SER A CA  1 
ATOM   1939 C C   . SER A 1 248 ? 20.262 -28.781 -2.345  1.00 18.19 ? 275 SER A C   1 
ATOM   1940 O O   . SER A 1 248 ? 20.003 -27.947 -1.493  1.00 18.78 ? 275 SER A O   1 
ATOM   1941 C CB  . SER A 1 248 ? 21.261 -27.926 -4.462  1.00 21.67 ? 275 SER A CB  1 
ATOM   1942 O OG  . SER A 1 248 ? 20.164 -28.473 -5.182  1.00 24.73 ? 275 SER A OG  1 
ATOM   1943 N N   . HIS A 1 249 ? 19.492 -29.842 -2.608  1.00 19.40 ? 276 HIS A N   1 
ATOM   1944 C CA  . HIS A 1 249 ? 18.166 -30.024 -2.037  1.00 18.86 ? 276 HIS A CA  1 
ATOM   1945 C C   . HIS A 1 249 ? 18.251 -30.353 -0.533  1.00 19.98 ? 276 HIS A C   1 
ATOM   1946 O O   . HIS A 1 249 ? 17.604 -29.707 0.294   1.00 18.26 ? 276 HIS A O   1 
ATOM   1947 C CB  . HIS A 1 249 ? 17.434 -31.064 -2.878  1.00 21.31 ? 276 HIS A CB  1 
ATOM   1948 C CG  . HIS A 1 249 ? 15.981 -31.212 -2.527  1.00 20.46 ? 276 HIS A CG  1 
ATOM   1949 N ND1 . HIS A 1 249 ? 15.551 -32.176 -1.661  1.00 20.62 ? 276 HIS A ND1 1 
ATOM   1950 C CD2 . HIS A 1 249 ? 14.901 -30.548 -2.919  1.00 20.23 ? 276 HIS A CD2 1 
ATOM   1951 C CE1 . HIS A 1 249 ? 14.214 -32.100 -1.566  1.00 22.52 ? 276 HIS A CE1 1 
ATOM   1952 N NE2 . HIS A 1 249 ? 13.816 -31.105 -2.316  1.00 21.97 ? 276 HIS A NE2 1 
ATOM   1953 N N   . LEU A 1 250 ? 19.139 -31.295 -0.194  1.00 18.11 ? 277 LEU A N   1 
ATOM   1954 C CA  . LEU A 1 250 ? 19.439 -31.746 1.151   1.00 20.04 ? 277 LEU A CA  1 
ATOM   1955 C C   . LEU A 1 250 ? 20.015 -30.632 2.039   1.00 20.76 ? 277 LEU A C   1 
ATOM   1956 O O   . LEU A 1 250 ? 19.528 -30.384 3.148   1.00 21.72 ? 277 LEU A O   1 
ATOM   1957 C CB  . LEU A 1 250 ? 20.414 -32.917 0.938   1.00 20.37 ? 277 LEU A CB  1 
ATOM   1958 C CG  . LEU A 1 250 ? 21.073 -33.500 2.189   1.00 21.24 ? 277 LEU A CG  1 
ATOM   1959 C CD1 . LEU A 1 250 ? 19.943 -33.977 3.080   1.00 19.51 ? 277 LEU A CD1 1 
ATOM   1960 C CD2 . LEU A 1 250 ? 22.011 -34.664 1.855   1.00 21.55 ? 277 LEU A CD2 1 
ATOM   1961 N N   . VAL A 1 251 ? 21.078 -29.973 1.585   1.00 19.27 ? 278 VAL A N   1 
ATOM   1962 C CA  . VAL A 1 251 ? 21.665 -28.899 2.365   1.00 18.36 ? 278 VAL A CA  1 
ATOM   1963 C C   . VAL A 1 251 ? 20.631 -27.782 2.509   1.00 18.59 ? 278 VAL A C   1 
ATOM   1964 O O   . VAL A 1 251 ? 20.412 -27.230 3.598   1.00 19.48 ? 278 VAL A O   1 
ATOM   1965 C CB  . VAL A 1 251 ? 23.003 -28.452 1.729   1.00 16.46 ? 278 VAL A CB  1 
ATOM   1966 C CG1 . VAL A 1 251 ? 23.495 -27.136 2.290   1.00 16.73 ? 278 VAL A CG1 1 
ATOM   1967 C CG2 . VAL A 1 251 ? 24.087 -29.523 1.852   1.00 15.86 ? 278 VAL A CG2 1 
ATOM   1968 N N   . GLY A 1 252 ? 19.936 -27.475 1.413   1.00 17.21 ? 279 GLY A N   1 
ATOM   1969 C CA  . GLY A 1 252 ? 18.921 -26.444 1.477   1.00 16.88 ? 279 GLY A CA  1 
ATOM   1970 C C   . GLY A 1 252 ? 17.810 -26.762 2.465   1.00 17.49 ? 279 GLY A C   1 
ATOM   1971 O O   . GLY A 1 252 ? 17.266 -25.831 3.060   1.00 18.11 ? 279 GLY A O   1 
ATOM   1972 N N   . SER A 1 253 ? 17.510 -28.054 2.677   1.00 15.66 ? 280 SER A N   1 
ATOM   1973 C CA  . SER A 1 253 ? 16.423 -28.469 3.564   1.00 17.24 ? 280 SER A CA  1 
ATOM   1974 C C   . SER A 1 253 ? 16.733 -28.143 5.022   1.00 17.69 ? 280 SER A C   1 
ATOM   1975 O O   . SER A 1 253 ? 15.826 -28.069 5.855   1.00 16.22 ? 280 SER A O   1 
ATOM   1976 C CB  . SER A 1 253 ? 16.128 -29.957 3.421   1.00 18.18 ? 280 SER A CB  1 
ATOM   1977 O OG  . SER A 1 253 ? 17.173 -30.723 3.987   1.00 17.53 ? 280 SER A OG  1 
ATOM   1978 N N   . ALA A 1 254 ? 18.017 -27.968 5.342   1.00 17.63 ? 281 ALA A N   1 
ATOM   1979 C CA  . ALA A 1 254 ? 18.424 -27.515 6.675   1.00 19.73 ? 281 ALA A CA  1 
ATOM   1980 C C   . ALA A 1 254 ? 18.389 -25.986 6.808   1.00 18.87 ? 281 ALA A C   1 
ATOM   1981 O O   . ALA A 1 254 ? 18.843 -25.454 7.828   1.00 17.99 ? 281 ALA A O   1 
ATOM   1982 C CB  . ALA A 1 254 ? 19.803 -28.038 7.014   1.00 20.21 ? 281 ALA A CB  1 
ATOM   1983 N N   . LEU A 1 255 ? 17.869 -25.316 5.771   1.00 18.68 ? 282 LEU A N   1 
ATOM   1984 C CA  . LEU A 1 255 ? 17.723 -23.865 5.683   1.00 18.54 ? 282 LEU A CA  1 
ATOM   1985 C C   . LEU A 1 255 ? 19.081 -23.160 5.531   1.00 21.32 ? 282 LEU A C   1 
ATOM   1986 O O   . LEU A 1 255 ? 19.224 -21.968 5.806   1.00 21.59 ? 282 LEU A O   1 
ATOM   1987 C CB  . LEU A 1 255 ? 16.891 -23.397 6.874   1.00 19.10 ? 282 LEU A CB  1 
ATOM   1988 C CG  . LEU A 1 255 ? 15.429 -23.872 6.865   1.00 18.75 ? 282 LEU A CG  1 
ATOM   1989 C CD1 . LEU A 1 255 ? 14.558 -23.186 7.887   1.00 22.60 ? 282 LEU A CD1 1 
ATOM   1990 C CD2 . LEU A 1 255 ? 14.820 -23.676 5.522   1.00 19.91 ? 282 LEU A CD2 1 
ATOM   1991 N N   . SER A 1 256 ? 20.089 -23.908 5.068   1.00 21.36 ? 283 SER A N   1 
ATOM   1992 C CA  . SER A 1 256 ? 21.284 -23.301 4.506   1.00 22.25 ? 283 SER A CA  1 
ATOM   1993 C C   . SER A 1 256 ? 20.896 -22.386 3.348   1.00 22.51 ? 283 SER A C   1 
ATOM   1994 O O   . SER A 1 256 ? 19.971 -22.690 2.602   1.00 20.50 ? 283 SER A O   1 
ATOM   1995 C CB  . SER A 1 256 ? 22.238 -24.345 4.083   1.00 21.31 ? 283 SER A CB  1 
ATOM   1996 O OG  . SER A 1 256 ? 22.648 -25.062 5.242   1.00 22.14 ? 283 SER A OG  1 
ATOM   1997 N N   . ASP A 1 257 ? 21.561 -21.230 3.250   1.00 20.63 ? 284 ASP A N   1 
ATOM   1998 C CA  . ASP A 1 257 ? 21.194 -20.262 2.239   1.00 20.43 ? 284 ASP A CA  1 
ATOM   1999 C C   . ASP A 1 257 ? 21.583 -20.790 0.854   1.00 21.25 ? 284 ASP A C   1 
ATOM   2000 O O   . ASP A 1 257 ? 22.291 -21.808 0.735   1.00 22.90 ? 284 ASP A O   1 
ATOM   2001 C CB  . ASP A 1 257 ? 21.793 -18.915 2.585   1.00 21.37 ? 284 ASP A CB  1 
ATOM   2002 C CG  . ASP A 1 257 ? 23.310 -18.867 2.588   1.00 21.92 ? 284 ASP A CG  1 
ATOM   2003 O OD1 . ASP A 1 257 ? 23.885 -19.043 1.498   1.00 20.76 ? 284 ASP A OD1 1 
ATOM   2004 O OD2 . ASP A 1 257 ? 23.895 -18.602 3.675   1.00 23.63 ? 284 ASP A OD2 1 
ATOM   2005 N N   . PRO A 1 258 ? 21.093 -20.139 -0.231  1.00 18.59 ? 285 PRO A N   1 
ATOM   2006 C CA  . PRO A 1 258 ? 21.385 -20.584 -1.593  1.00 19.19 ? 285 PRO A CA  1 
ATOM   2007 C C   . PRO A 1 258 ? 22.878 -20.701 -1.873  1.00 21.65 ? 285 PRO A C   1 
ATOM   2008 O O   . PRO A 1 258 ? 23.311 -21.596 -2.595  1.00 20.84 ? 285 PRO A O   1 
ATOM   2009 C CB  . PRO A 1 258 ? 20.715 -19.514 -2.447  1.00 20.26 ? 285 PRO A CB  1 
ATOM   2010 C CG  . PRO A 1 258 ? 19.533 -19.075 -1.606  1.00 20.92 ? 285 PRO A CG  1 
ATOM   2011 C CD  . PRO A 1 258 ? 20.120 -19.029 -0.197  1.00 19.76 ? 285 PRO A CD  1 
ATOM   2012 N N   . TYR A 1 259 ? 23.671 -19.791 -1.295  1.00 21.26 ? 286 TYR A N   1 
ATOM   2013 C CA  . TYR A 1 259 ? 25.096 -19.845 -1.542  1.00 21.17 ? 286 TYR A CA  1 
ATOM   2014 C C   . TYR A 1 259 ? 25.687 -21.138 -0.986  1.00 19.21 ? 286 TYR A C   1 
ATOM   2015 O O   . TYR A 1 259 ? 26.407 -21.830 -1.687  1.00 20.50 ? 286 TYR A O   1 
ATOM   2016 C CB  . TYR A 1 259 ? 25.766 -18.611 -0.956  1.00 20.21 ? 286 TYR A CB  1 
ATOM   2017 C CG  . TYR A 1 259 ? 25.355 -17.294 -1.578  1.00 19.82 ? 286 TYR A CG  1 
ATOM   2018 C CD1 . TYR A 1 259 ? 25.986 -16.831 -2.722  1.00 20.44 ? 286 TYR A CD1 1 
ATOM   2019 C CD2 . TYR A 1 259 ? 24.331 -16.528 -1.040  1.00 19.77 ? 286 TYR A CD2 1 
ATOM   2020 C CE1 . TYR A 1 259 ? 25.631 -15.614 -3.292  1.00 21.18 ? 286 TYR A CE1 1 
ATOM   2021 C CE2 . TYR A 1 259 ? 23.957 -15.320 -1.611  1.00 20.20 ? 286 TYR A CE2 1 
ATOM   2022 C CZ  . TYR A 1 259 ? 24.619 -14.854 -2.731  1.00 21.05 ? 286 TYR A CZ  1 
ATOM   2023 O OH  . TYR A 1 259 ? 24.299 -13.645 -3.276  1.00 21.05 ? 286 TYR A OH  1 
ATOM   2024 N N   . LEU A 1 260 ? 25.387 -21.463 0.274   1.00 20.89 ? 287 LEU A N   1 
ATOM   2025 C CA  . LEU A 1 260 ? 25.912 -22.674 0.881   1.00 18.49 ? 287 LEU A CA  1 
ATOM   2026 C C   . LEU A 1 260 ? 25.401 -23.917 0.144   1.00 17.81 ? 287 LEU A C   1 
ATOM   2027 O O   . LEU A 1 260 ? 26.143 -24.898 0.010   1.00 15.87 ? 287 LEU A O   1 
ATOM   2028 C CB  . LEU A 1 260 ? 25.569 -22.740 2.369   1.00 18.84 ? 287 LEU A CB  1 
ATOM   2029 C CG  . LEU A 1 260 ? 26.128 -21.612 3.247   1.00 18.30 ? 287 LEU A CG  1 
ATOM   2030 C CD1 . LEU A 1 260 ? 25.675 -21.810 4.707   1.00 19.41 ? 287 LEU A CD1 1 
ATOM   2031 C CD2 . LEU A 1 260 ? 27.664 -21.475 3.172   1.00 16.70 ? 287 LEU A CD2 1 
ATOM   2032 N N   . SER A 1 261 ? 24.111 -23.926 -0.222  1.00 16.39 ? 288 SER A N   1 
ATOM   2033 C CA  . SER A 1 261 ? 23.475 -25.085 -0.836  1.00 17.97 ? 288 SER A CA  1 
ATOM   2034 C C   . SER A 1 261 ? 24.078 -25.345 -2.206  1.00 18.15 ? 288 SER A C   1 
ATOM   2035 O O   . SER A 1 261 ? 24.257 -26.494 -2.606  1.00 17.87 ? 288 SER A O   1 
ATOM   2036 C CB  . SER A 1 261 ? 21.976 -24.896 -0.985  1.00 17.52 ? 288 SER A CB  1 
ATOM   2037 O OG  . SER A 1 261 ? 21.418 -24.622 0.296   1.00 20.93 ? 288 SER A OG  1 
ATOM   2038 N N   . PHE A 1 262 ? 24.326 -24.252 -2.932  1.00 18.94 ? 289 PHE A N   1 
ATOM   2039 C CA  . PHE A 1 262 ? 24.900 -24.376 -4.259  1.00 17.59 ? 289 PHE A CA  1 
ATOM   2040 C C   . PHE A 1 262 ? 26.360 -24.829 -4.164  1.00 18.62 ? 289 PHE A C   1 
ATOM   2041 O O   . PHE A 1 262 ? 26.804 -25.578 -5.026  1.00 16.55 ? 289 PHE A O   1 
ATOM   2042 C CB  . PHE A 1 262 ? 24.835 -23.078 -5.041  1.00 18.60 ? 289 PHE A CB  1 
ATOM   2043 C CG  . PHE A 1 262 ? 25.393 -23.217 -6.447  1.00 19.29 ? 289 PHE A CG  1 
ATOM   2044 C CD1 . PHE A 1 262 ? 24.705 -23.922 -7.424  1.00 20.55 ? 289 PHE A CD1 1 
ATOM   2045 C CD2 . PHE A 1 262 ? 26.614 -22.670 -6.772  1.00 20.43 ? 289 PHE A CD2 1 
ATOM   2046 C CE1 . PHE A 1 262 ? 25.227 -24.041 -8.702  1.00 20.53 ? 289 PHE A CE1 1 
ATOM   2047 C CE2 . PHE A 1 262 ? 27.131 -22.811 -8.041  1.00 22.36 ? 289 PHE A CE2 1 
ATOM   2048 C CZ  . PHE A 1 262 ? 26.428 -23.491 -9.003  1.00 21.12 ? 289 PHE A CZ  1 
ATOM   2049 N N   . ALA A 1 263 ? 27.127 -24.315 -3.193  1.00 19.40 ? 290 ALA A N   1 
ATOM   2050 C CA  . ALA A 1 263 ? 28.542 -24.655 -3.089  1.00 20.53 ? 290 ALA A CA  1 
ATOM   2051 C C   . ALA A 1 263 ? 28.724 -26.133 -2.763  1.00 19.86 ? 290 ALA A C   1 
ATOM   2052 O O   . ALA A 1 263 ? 29.629 -26.777 -3.264  1.00 21.91 ? 290 ALA A O   1 
ATOM   2053 C CB  . ALA A 1 263 ? 29.245 -23.791 -2.054  1.00 20.95 ? 290 ALA A CB  1 
ATOM   2054 N N   . ALA A 1 264 ? 27.868 -26.636 -1.895  1.00 19.61 ? 291 ALA A N   1 
ATOM   2055 C CA  . ALA A 1 264 ? 27.799 -28.045 -1.581  1.00 22.11 ? 291 ALA A CA  1 
ATOM   2056 C C   . ALA A 1 264 ? 27.437 -28.850 -2.833  1.00 20.26 ? 291 ALA A C   1 
ATOM   2057 O O   . ALA A 1 264 ? 28.071 -29.861 -3.075  1.00 20.95 ? 291 ALA A O   1 
ATOM   2058 C CB  . ALA A 1 264 ? 26.817 -28.291 -0.448  1.00 19.87 ? 291 ALA A CB  1 
ATOM   2059 N N   . ALA A 1 265 ? 26.453 -28.401 -3.618  1.00 20.23 ? 292 ALA A N   1 
ATOM   2060 C CA  . ALA A 1 265 ? 26.158 -29.032 -4.898  1.00 20.82 ? 292 ALA A CA  1 
ATOM   2061 C C   . ALA A 1 265 ? 27.397 -29.093 -5.792  1.00 19.87 ? 292 ALA A C   1 
ATOM   2062 O O   . ALA A 1 265 ? 27.621 -30.099 -6.454  1.00 19.99 ? 292 ALA A O   1 
ATOM   2063 C CB  . ALA A 1 265 ? 25.044 -28.321 -5.616  1.00 23.77 ? 292 ALA A CB  1 
ATOM   2064 N N   . MET A 1 266 ? 28.209 -28.034 -5.798  1.00 20.54 ? 293 MET A N   1 
ATOM   2065 C CA  . MET A 1 266 ? 29.383 -27.980 -6.659  1.00 19.87 ? 293 MET A CA  1 
ATOM   2066 C C   . MET A 1 266 ? 30.408 -29.024 -6.223  1.00 19.62 ? 293 MET A C   1 
ATOM   2067 O O   . MET A 1 266 ? 31.099 -29.617 -7.058  1.00 18.18 ? 293 MET A O   1 
ATOM   2068 C CB  . MET A 1 266 ? 29.996 -26.584 -6.709  1.00 19.03 ? 293 MET A CB  1 
ATOM   2069 C CG  . MET A 1 266 ? 29.129 -25.591 -7.471  1.00 21.63 ? 293 MET A CG  1 
ATOM   2070 S SD  . MET A 1 266 ? 28.762 -26.139 -9.153  1.00 21.66 ? 293 MET A SD  1 
ATOM   2071 C CE  . MET A 1 266 ? 27.212 -27.014 -8.903  1.00 24.86 ? 293 MET A CE  1 
ATOM   2072 N N   . ASN A 1 267 ? 30.524 -29.226 -4.912  1.00 17.70 ? 294 ASN A N   1 
ATOM   2073 C CA  . ASN A 1 267 ? 31.433 -30.233 -4.413  1.00 19.89 ? 294 ASN A CA  1 
ATOM   2074 C C   . ASN A 1 267 ? 31.001 -31.614 -4.900  1.00 18.92 ? 294 ASN A C   1 
ATOM   2075 O O   . ASN A 1 267 ? 31.849 -32.476 -5.123  1.00 19.25 ? 294 ASN A O   1 
ATOM   2076 C CB  . ASN A 1 267 ? 31.573 -30.136 -2.900  1.00 21.11 ? 294 ASN A CB  1 
ATOM   2077 C CG  . ASN A 1 267 ? 32.515 -29.055 -2.444  1.00 22.08 ? 294 ASN A CG  1 
ATOM   2078 O OD1 . ASN A 1 267 ? 32.992 -28.238 -3.239  1.00 23.15 ? 294 ASN A OD1 1 
ATOM   2079 N ND2 . ASN A 1 267 ? 32.766 -29.027 -1.145  1.00 24.25 ? 294 ASN A ND2 1 
ATOM   2080 N N   . GLY A 1 268 ? 29.693 -31.825 -5.069  1.00 17.38 ? 295 GLY A N   1 
ATOM   2081 C CA  . GLY A 1 268 ? 29.190 -33.073 -5.632  1.00 19.29 ? 295 GLY A CA  1 
ATOM   2082 C C   . GLY A 1 268 ? 29.409 -33.187 -7.143  1.00 19.93 ? 295 GLY A C   1 
ATOM   2083 O O   . GLY A 1 268 ? 29.780 -34.251 -7.640  1.00 18.54 ? 295 GLY A O   1 
ATOM   2084 N N   . LEU A 1 269 ? 29.210 -32.078 -7.864  1.00 19.63 ? 296 LEU A N   1 
ATOM   2085 C CA  . LEU A 1 269 ? 29.426 -32.033 -9.299  1.00 19.66 ? 296 LEU A CA  1 
ATOM   2086 C C   . LEU A 1 269 ? 30.912 -32.208 -9.607  1.00 21.07 ? 296 LEU A C   1 
ATOM   2087 O O   . LEU A 1 269 ? 31.257 -32.612 -10.710 1.00 20.69 ? 296 LEU A O   1 
ATOM   2088 C CB  . LEU A 1 269 ? 28.920 -30.718 -9.876  1.00 20.76 ? 296 LEU A CB  1 
ATOM   2089 C CG  . LEU A 1 269 ? 28.855 -30.679 -11.403 1.00 22.02 ? 296 LEU A CG  1 
ATOM   2090 C CD1 . LEU A 1 269 ? 27.894 -31.715 -11.945 1.00 21.76 ? 296 LEU A CD1 1 
ATOM   2091 C CD2 . LEU A 1 269 ? 28.435 -29.294 -11.819 1.00 23.63 ? 296 LEU A CD2 1 
ATOM   2092 N N   . ALA A 1 270 ? 31.786 -31.883 -8.645  1.00 19.22 ? 297 ALA A N   1 
ATOM   2093 C CA  . ALA A 1 270 ? 33.216 -32.007 -8.864  1.00 20.49 ? 297 ALA A CA  1 
ATOM   2094 C C   . ALA A 1 270 ? 33.637 -33.474 -8.863  1.00 19.73 ? 297 ALA A C   1 
ATOM   2095 O O   . ALA A 1 270 ? 34.749 -33.806 -9.273  1.00 17.33 ? 297 ALA A O   1 
ATOM   2096 C CB  . ALA A 1 270 ? 33.984 -31.220 -7.824  1.00 20.38 ? 297 ALA A CB  1 
ATOM   2097 N N   . GLY A 1 271 ? 32.746 -34.355 -8.396  1.00 21.03 ? 298 GLY A N   1 
ATOM   2098 C CA  . GLY A 1 271 ? 33.104 -35.754 -8.247  1.00 20.91 ? 298 GLY A CA  1 
ATOM   2099 C C   . GLY A 1 271 ? 33.243 -36.381 -9.623  1.00 22.60 ? 298 GLY A C   1 
ATOM   2100 O O   . GLY A 1 271 ? 32.425 -36.108 -10.485 1.00 19.96 ? 298 GLY A O   1 
ATOM   2101 N N   . PRO A 1 272 ? 34.256 -37.242 -9.855  1.00 22.69 ? 299 PRO A N   1 
ATOM   2102 C CA  . PRO A 1 272 ? 34.368 -37.958 -11.124 1.00 23.29 ? 299 PRO A CA  1 
ATOM   2103 C C   . PRO A 1 272 ? 33.090 -38.594 -11.682 1.00 23.62 ? 299 PRO A C   1 
ATOM   2104 O O   . PRO A 1 272 ? 32.855 -38.556 -12.883 1.00 23.72 ? 299 PRO A O   1 
ATOM   2105 C CB  . PRO A 1 272 ? 35.394 -39.024 -10.769 1.00 24.66 ? 299 PRO A CB  1 
ATOM   2106 C CG  . PRO A 1 272 ? 36.275 -38.364 -9.741  1.00 24.52 ? 299 PRO A CG  1 
ATOM   2107 C CD  . PRO A 1 272 ? 35.299 -37.592 -8.884  1.00 23.10 ? 299 PRO A CD  1 
ATOM   2108 N N   . LEU A 1 273 ? 32.274 -39.206 -10.815 1.00 24.19 ? 300 LEU A N   1 
ATOM   2109 C CA  . LEU A 1 273 ? 31.089 -39.914 -11.278 1.00 24.70 ? 300 LEU A CA  1 
ATOM   2110 C C   . LEU A 1 273 ? 29.894 -38.977 -11.471 1.00 25.18 ? 300 LEU A C   1 
ATOM   2111 O O   . LEU A 1 273 ? 28.820 -39.472 -11.800 1.00 31.39 ? 300 LEU A O   1 
ATOM   2112 C CB  . LEU A 1 273 ? 30.711 -41.040 -10.318 1.00 25.96 ? 300 LEU A CB  1 
ATOM   2113 C CG  . LEU A 1 273 ? 31.770 -42.125 -10.101 1.00 27.03 ? 300 LEU A CG  1 
ATOM   2114 C CD1 . LEU A 1 273 ? 31.225 -43.231 -9.193  1.00 27.02 ? 300 LEU A CD1 1 
ATOM   2115 C CD2 . LEU A 1 273 ? 32.252 -42.706 -11.429 1.00 25.76 ? 300 LEU A CD2 1 
ATOM   2116 N N   . HIS A 1 274 ? 30.043 -37.654 -11.296 1.00 22.96 ? 301 HIS A N   1 
ATOM   2117 C CA  . HIS A 1 274 ? 28.941 -36.757 -11.612 1.00 24.98 ? 301 HIS A CA  1 
ATOM   2118 C C   . HIS A 1 274 ? 29.274 -35.750 -12.720 1.00 27.55 ? 301 HIS A C   1 
ATOM   2119 O O   . HIS A 1 274 ? 28.553 -35.695 -13.704 1.00 28.48 ? 301 HIS A O   1 
ATOM   2120 C CB  . HIS A 1 274 ? 28.381 -36.037 -10.375 1.00 24.81 ? 301 HIS A CB  1 
ATOM   2121 C CG  . HIS A 1 274 ? 27.082 -35.326 -10.663 1.00 26.70 ? 301 HIS A CG  1 
ATOM   2122 N ND1 . HIS A 1 274 ? 26.625 -34.185 -10.025 1.00 27.76 ? 301 HIS A ND1 1 
ATOM   2123 C CD2 . HIS A 1 274 ? 26.168 -35.606 -11.602 1.00 29.30 ? 301 HIS A CD2 1 
ATOM   2124 C CE1 . HIS A 1 274 ? 25.467 -33.815 -10.552 1.00 28.87 ? 301 HIS A CE1 1 
ATOM   2125 N NE2 . HIS A 1 274 ? 25.172 -34.662 -11.517 1.00 34.99 ? 301 HIS A NE2 1 
ATOM   2126 N N   . GLY A 1 275 ? 30.303 -34.909 -12.550 1.00 27.62 ? 302 GLY A N   1 
ATOM   2127 C CA  . GLY A 1 275 ? 30.538 -33.817 -13.486 1.00 27.23 ? 302 GLY A CA  1 
ATOM   2128 C C   . GLY A 1 275 ? 31.832 -33.927 -14.287 1.00 26.28 ? 302 GLY A C   1 
ATOM   2129 O O   . GLY A 1 275 ? 32.197 -32.958 -14.933 1.00 28.39 ? 302 GLY A O   1 
ATOM   2130 N N   . LEU A 1 276 ? 32.514 -35.083 -14.304 1.00 27.50 ? 303 LEU A N   1 
ATOM   2131 C CA  . LEU A 1 276 ? 33.787 -35.183 -15.013 1.00 31.89 ? 303 LEU A CA  1 
ATOM   2132 C C   . LEU A 1 276 ? 33.713 -35.977 -16.327 1.00 32.08 ? 303 LEU A C   1 
ATOM   2133 O O   . LEU A 1 276 ? 34.704 -36.062 -17.045 1.00 26.21 ? 303 LEU A O   1 
ATOM   2134 C CB  . LEU A 1 276 ? 34.851 -35.743 -14.079 1.00 33.85 ? 303 LEU A CB  1 
ATOM   2135 C CG  . LEU A 1 276 ? 35.717 -34.687 -13.381 1.00 37.75 ? 303 LEU A CG  1 
ATOM   2136 C CD1 . LEU A 1 276 ? 34.892 -33.728 -12.554 1.00 37.52 ? 303 LEU A CD1 1 
ATOM   2137 C CD2 . LEU A 1 276 ? 36.778 -35.351 -12.519 1.00 38.66 ? 303 LEU A CD2 1 
ATOM   2138 N N   . ALA A 1 277 ? 32.546 -36.514 -16.695 1.00 31.14 ? 304 ALA A N   1 
ATOM   2139 C CA  . ALA A 1 277 ? 32.436 -37.362 -17.881 1.00 29.30 ? 304 ALA A CA  1 
ATOM   2140 C C   . ALA A 1 277 ? 32.885 -36.659 -19.161 1.00 31.08 ? 304 ALA A C   1 
ATOM   2141 O O   . ALA A 1 277 ? 33.432 -37.301 -20.049 1.00 29.14 ? 304 ALA A O   1 
ATOM   2142 C CB  . ALA A 1 277 ? 31.018 -37.849 -18.044 1.00 29.27 ? 304 ALA A CB  1 
ATOM   2143 N N   . ASN A 1 278 ? 32.594 -35.359 -19.283 1.00 28.05 ? 305 ASN A N   1 
ATOM   2144 C CA  . ASN A 1 278 ? 32.994 -34.576 -20.444 1.00 25.64 ? 305 ASN A CA  1 
ATOM   2145 C C   . ASN A 1 278 ? 34.498 -34.749 -20.680 1.00 26.35 ? 305 ASN A C   1 
ATOM   2146 O O   . ASN A 1 278 ? 34.953 -35.048 -21.786 1.00 24.01 ? 305 ASN A O   1 
ATOM   2147 C CB  . ASN A 1 278 ? 32.553 -33.131 -20.233 1.00 24.83 ? 305 ASN A CB  1 
ATOM   2148 C CG  . ASN A 1 278 ? 33.021 -32.174 -21.294 1.00 26.89 ? 305 ASN A CG  1 
ATOM   2149 O OD1 . ASN A 1 278 ? 33.821 -32.527 -22.166 1.00 32.29 ? 305 ASN A OD1 1 
ATOM   2150 N ND2 . ASN A 1 278 ? 32.579 -30.934 -21.219 1.00 27.25 ? 305 ASN A ND2 1 
ATOM   2151 N N   . GLN A 1 279 ? 35.273 -34.594 -19.610 1.00 24.95 ? 306 GLN A N   1 
ATOM   2152 C CA  . GLN A 1 279 ? 36.720 -34.620 -19.703 1.00 26.06 ? 306 GLN A CA  1 
ATOM   2153 C C   . GLN A 1 279 ? 37.182 -36.040 -20.022 1.00 25.80 ? 306 GLN A C   1 
ATOM   2154 O O   . GLN A 1 279 ? 38.078 -36.244 -20.841 1.00 25.50 ? 306 GLN A O   1 
ATOM   2155 C CB  . GLN A 1 279 ? 37.299 -34.054 -18.404 1.00 26.70 ? 306 GLN A CB  1 
ATOM   2156 C CG  . GLN A 1 279 ? 37.018 -32.560 -18.252 1.00 32.68 ? 306 GLN A CG  1 
ATOM   2157 C CD  . GLN A 1 279 ? 35.881 -32.183 -17.308 1.00 33.05 ? 306 GLN A CD  1 
ATOM   2158 O OE1 . GLN A 1 279 ? 34.701 -32.547 -17.501 1.00 29.19 ? 306 GLN A OE1 1 
ATOM   2159 N NE2 . GLN A 1 279 ? 36.236 -31.390 -16.304 1.00 26.84 ? 306 GLN A NE2 1 
ATOM   2160 N N   . GLU A 1 280 ? 36.531 -37.011 -19.386 1.00 24.99 ? 307 GLU A N   1 
ATOM   2161 C CA  . GLU A 1 280 ? 36.849 -38.412 -19.568 1.00 26.95 ? 307 GLU A CA  1 
ATOM   2162 C C   . GLU A 1 280 ? 36.679 -38.767 -21.037 1.00 27.04 ? 307 GLU A C   1 
ATOM   2163 O O   . GLU A 1 280 ? 37.488 -39.513 -21.564 1.00 23.81 ? 307 GLU A O   1 
ATOM   2164 C CB  . GLU A 1 280 ? 35.994 -39.305 -18.678 1.00 26.63 ? 307 GLU A CB  1 
ATOM   2165 C CG  . GLU A 1 280 ? 36.336 -39.125 -17.205 1.00 33.43 ? 307 GLU A CG  1 
ATOM   2166 C CD  . GLU A 1 280 ? 35.377 -39.742 -16.198 1.00 36.98 ? 307 GLU A CD  1 
ATOM   2167 O OE1 . GLU A 1 280 ? 34.388 -40.377 -16.639 1.00 42.88 ? 307 GLU A OE1 1 
ATOM   2168 O OE2 . GLU A 1 280 ? 35.634 -39.599 -14.971 1.00 35.66 ? 307 GLU A OE2 1 
ATOM   2169 N N   . VAL A 1 281 ? 35.622 -38.237 -21.669 1.00 25.82 ? 308 VAL A N   1 
ATOM   2170 C CA  . VAL A 1 281 ? 35.344 -38.538 -23.057 1.00 26.25 ? 308 VAL A CA  1 
ATOM   2171 C C   . VAL A 1 281 ? 36.480 -38.002 -23.913 1.00 28.01 ? 308 VAL A C   1 
ATOM   2172 O O   . VAL A 1 281 ? 37.082 -38.759 -24.663 1.00 31.24 ? 308 VAL A O   1 
ATOM   2173 C CB  . VAL A 1 281 ? 33.971 -37.999 -23.501 1.00 28.09 ? 308 VAL A CB  1 
ATOM   2174 C CG1 . VAL A 1 281 ? 33.809 -38.033 -25.017 1.00 31.51 ? 308 VAL A CG1 1 
ATOM   2175 C CG2 . VAL A 1 281 ? 32.842 -38.753 -22.816 1.00 24.76 ? 308 VAL A CG2 1 
ATOM   2176 N N   . LEU A 1 282 ? 36.820 -36.722 -23.732 1.00 26.63 ? 309 LEU A N   1 
ATOM   2177 C CA  . LEU A 1 282 ? 37.844 -36.069 -24.527 1.00 27.27 ? 309 LEU A CA  1 
ATOM   2178 C C   . LEU A 1 282 ? 39.179 -36.796 -24.362 1.00 29.13 ? 309 LEU A C   1 
ATOM   2179 O O   . LEU A 1 282 ? 39.866 -37.052 -25.354 1.00 27.49 ? 309 LEU A O   1 
ATOM   2180 C CB  . LEU A 1 282 ? 37.901 -34.602 -24.111 1.00 30.74 ? 309 LEU A CB  1 
ATOM   2181 C CG  . LEU A 1 282 ? 38.071 -33.551 -25.204 1.00 36.65 ? 309 LEU A CG  1 
ATOM   2182 C CD1 . LEU A 1 282 ? 37.157 -33.830 -26.390 1.00 40.49 ? 309 LEU A CD1 1 
ATOM   2183 C CD2 . LEU A 1 282 ? 37.810 -32.147 -24.673 1.00 32.83 ? 309 LEU A CD2 1 
ATOM   2184 N N   . VAL A 1 283 ? 39.522 -37.169 -23.122 1.00 26.60 ? 310 VAL A N   1 
ATOM   2185 C CA  . VAL A 1 283 ? 40.741 -37.906 -22.852 1.00 27.55 ? 310 VAL A CA  1 
ATOM   2186 C C   . VAL A 1 283 ? 40.712 -39.246 -23.575 1.00 27.68 ? 310 VAL A C   1 
ATOM   2187 O O   . VAL A 1 283 ? 41.737 -39.666 -24.100 1.00 29.17 ? 310 VAL A O   1 
ATOM   2188 C CB  . VAL A 1 283 ? 40.972 -38.046 -21.333 1.00 29.24 ? 310 VAL A CB  1 
ATOM   2189 C CG1 . VAL A 1 283 ? 41.961 -39.147 -20.987 1.00 28.35 ? 310 VAL A CG1 1 
ATOM   2190 C CG2 . VAL A 1 283 ? 41.431 -36.724 -20.733 1.00 27.20 ? 310 VAL A CG2 1 
ATOM   2191 N N   . TRP A 1 284 ? 39.543 -39.905 -23.614 1.00 27.40 ? 311 TRP A N   1 
ATOM   2192 C CA  . TRP A 1 284 ? 39.394 -41.190 -24.278 1.00 28.15 ? 311 TRP A CA  1 
ATOM   2193 C C   . TRP A 1 284 ? 39.500 -41.074 -25.800 1.00 28.98 ? 311 TRP A C   1 
ATOM   2194 O O   . TRP A 1 284 ? 40.162 -41.888 -26.434 1.00 27.87 ? 311 TRP A O   1 
ATOM   2195 C CB  . TRP A 1 284 ? 38.069 -41.829 -23.877 1.00 31.35 ? 311 TRP A CB  1 
ATOM   2196 C CG  . TRP A 1 284 ? 37.880 -43.242 -24.366 1.00 31.23 ? 311 TRP A CG  1 
ATOM   2197 C CD1 . TRP A 1 284 ? 38.340 -44.389 -23.791 1.00 31.72 ? 311 TRP A CD1 1 
ATOM   2198 C CD2 . TRP A 1 284 ? 37.088 -43.645 -25.502 1.00 32.30 ? 311 TRP A CD2 1 
ATOM   2199 N NE1 . TRP A 1 284 ? 37.902 -45.483 -24.491 1.00 30.74 ? 311 TRP A NE1 1 
ATOM   2200 C CE2 . TRP A 1 284 ? 37.134 -45.059 -25.546 1.00 34.93 ? 311 TRP A CE2 1 
ATOM   2201 C CE3 . TRP A 1 284 ? 36.354 -42.955 -26.474 1.00 36.04 ? 311 TRP A CE3 1 
ATOM   2202 C CZ2 . TRP A 1 284 ? 36.476 -45.786 -26.541 1.00 35.64 ? 311 TRP A CZ2 1 
ATOM   2203 C CZ3 . TRP A 1 284 ? 35.713 -43.675 -27.464 1.00 35.29 ? 311 TRP A CZ3 1 
ATOM   2204 C CH2 . TRP A 1 284 ? 35.761 -45.073 -27.481 1.00 36.28 ? 311 TRP A CH2 1 
ATOM   2205 N N   . LEU A 1 285 ? 38.837 -40.079 -26.383 1.00 30.28 ? 312 LEU A N   1 
ATOM   2206 C CA  . LEU A 1 285 ? 38.978 -39.806 -27.804 1.00 30.99 ? 312 LEU A CA  1 
ATOM   2207 C C   . LEU A 1 285 ? 40.443 -39.526 -28.151 1.00 33.93 ? 312 LEU A C   1 
ATOM   2208 O O   . LEU A 1 285 ? 40.907 -39.911 -29.221 1.00 36.69 ? 312 LEU A O   1 
ATOM   2209 C CB  . LEU A 1 285 ? 38.089 -38.633 -28.210 1.00 29.16 ? 312 LEU A CB  1 
ATOM   2210 C CG  . LEU A 1 285 ? 36.576 -38.800 -28.010 1.00 31.01 ? 312 LEU A CG  1 
ATOM   2211 C CD1 . LEU A 1 285 ? 35.857 -37.500 -28.272 1.00 31.05 ? 312 LEU A CD1 1 
ATOM   2212 C CD2 . LEU A 1 285 ? 35.990 -39.884 -28.896 1.00 32.75 ? 312 LEU A CD2 1 
ATOM   2213 N N   . THR A 1 286 ? 41.181 -38.825 -27.281 1.00 30.91 ? 313 THR A N   1 
ATOM   2214 C CA  . THR A 1 286 ? 42.551 -38.460 -27.608 1.00 31.16 ? 313 THR A CA  1 
ATOM   2215 C C   . THR A 1 286 ? 43.410 -39.728 -27.630 1.00 32.54 ? 313 THR A C   1 
ATOM   2216 O O   . THR A 1 286 ? 44.145 -39.962 -28.576 1.00 32.09 ? 313 THR A O   1 
ATOM   2217 C CB  . THR A 1 286 ? 43.075 -37.397 -26.645 1.00 33.32 ? 313 THR A CB  1 
ATOM   2218 O OG1 . THR A 1 286 ? 42.272 -36.257 -26.930 1.00 38.54 ? 313 THR A OG1 1 
ATOM   2219 C CG2 . THR A 1 286 ? 44.540 -37.065 -26.873 1.00 34.05 ? 313 THR A CG2 1 
ATOM   2220 N N   . GLN A 1 287 ? 43.301 -40.556 -26.594 1.00 29.65 ? 314 GLN A N   1 
ATOM   2221 C CA  . GLN A 1 287 ? 43.945 -41.852 -26.572 1.00 33.10 ? 314 GLN A CA  1 
ATOM   2222 C C   . GLN A 1 287 ? 43.553 -42.666 -27.810 1.00 36.21 ? 314 GLN A C   1 
ATOM   2223 O O   . GLN A 1 287 ? 44.360 -43.419 -28.348 1.00 31.31 ? 314 GLN A O   1 
ATOM   2224 C CB  . GLN A 1 287 ? 43.568 -42.541 -25.257 1.00 34.57 ? 314 GLN A CB  1 
ATOM   2225 C CG  . GLN A 1 287 ? 44.429 -43.740 -24.887 1.00 38.00 ? 314 GLN A CG  1 
ATOM   2226 C CD  . GLN A 1 287 ? 45.905 -43.391 -24.839 1.00 51.37 ? 314 GLN A CD  1 
ATOM   2227 O OE1 . GLN A 1 287 ? 46.301 -42.212 -24.796 1.00 53.68 ? 314 GLN A OE1 1 
ATOM   2228 N NE2 . GLN A 1 287 ? 46.742 -44.420 -24.862 1.00 54.04 ? 314 GLN A NE2 1 
ATOM   2229 N N   . LEU A 1 288 ? 42.299 -42.544 -28.246 1.00 35.25 ? 315 LEU A N   1 
ATOM   2230 C CA  . LEU A 1 288 ? 41.810 -43.307 -29.381 1.00 36.83 ? 315 LEU A CA  1 
ATOM   2231 C C   . LEU A 1 288 ? 42.662 -43.012 -30.609 1.00 36.65 ? 315 LEU A C   1 
ATOM   2232 O O   . LEU A 1 288 ? 43.202 -43.919 -31.233 1.00 39.96 ? 315 LEU A O   1 
ATOM   2233 C CB  . LEU A 1 288 ? 40.346 -42.962 -29.640 1.00 38.78 ? 315 LEU A CB  1 
ATOM   2234 C CG  . LEU A 1 288 ? 39.619 -43.807 -30.693 1.00 41.38 ? 315 LEU A CG  1 
ATOM   2235 C CD1 . LEU A 1 288 ? 40.143 -45.214 -30.752 1.00 41.33 ? 315 LEU A CD1 1 
ATOM   2236 C CD2 . LEU A 1 288 ? 38.147 -43.858 -30.346 1.00 39.22 ? 315 LEU A CD2 1 
ATOM   2237 N N   . GLN A 1 289 ? 42.775 -41.729 -30.937 1.00 36.13 ? 316 GLN A N   1 
ATOM   2238 C CA  . GLN A 1 289 ? 43.478 -41.306 -32.132 1.00 41.37 ? 316 GLN A CA  1 
ATOM   2239 C C   . GLN A 1 289 ? 44.941 -41.727 -32.006 1.00 43.76 ? 316 GLN A C   1 
ATOM   2240 O O   . GLN A 1 289 ? 45.473 -42.391 -32.895 1.00 39.72 ? 316 GLN A O   1 
ATOM   2241 C CB  . GLN A 1 289 ? 43.202 -39.821 -32.333 1.00 40.33 ? 316 GLN A CB  1 
ATOM   2242 C CG  . GLN A 1 289 ? 41.716 -39.529 -32.476 1.00 41.42 ? 316 GLN A CG  1 
ATOM   2243 C CD  . GLN A 1 289 ? 41.456 -38.202 -33.137 1.00 42.57 ? 316 GLN A CD  1 
ATOM   2244 O OE1 . GLN A 1 289 ? 42.005 -37.178 -32.724 1.00 51.54 ? 316 GLN A OE1 1 
ATOM   2245 N NE2 . GLN A 1 289 ? 40.680 -38.222 -34.209 1.00 44.06 ? 316 GLN A NE2 1 
ATOM   2246 N N   . LYS A 1 290 ? 45.539 -41.413 -30.856 1.00 36.71 ? 317 LYS A N   1 
ATOM   2247 C CA  . LYS A 1 290 ? 46.895 -41.825 -30.553 1.00 44.52 ? 317 LYS A CA  1 
ATOM   2248 C C   . LYS A 1 290 ? 47.094 -43.297 -30.872 1.00 42.04 ? 317 LYS A C   1 
ATOM   2249 O O   . LYS A 1 290 ? 48.141 -43.650 -31.383 1.00 41.37 ? 317 LYS A O   1 
ATOM   2250 C CB  . LYS A 1 290 ? 47.290 -41.650 -29.083 1.00 50.38 ? 317 LYS A CB  1 
ATOM   2251 C CG  . LYS A 1 290 ? 47.685 -40.233 -28.669 1.00 61.42 ? 317 LYS A CG  1 
ATOM   2252 C CD  . LYS A 1 290 ? 47.936 -40.044 -27.173 1.00 72.65 ? 317 LYS A CD  1 
ATOM   2253 C CE  . LYS A 1 290 ? 48.793 -41.107 -26.533 1.00 78.85 ? 317 LYS A CE  1 
ATOM   2254 N NZ  . LYS A 1 290 ? 50.096 -41.259 -27.186 1.00 81.95 ? 317 LYS A NZ  1 
ATOM   2255 N N   . GLU A 1 291 ? 46.115 -44.147 -30.548 1.00 42.02 ? 318 GLU A N   1 
ATOM   2256 C CA  . GLU A 1 291 ? 46.330 -45.582 -30.621 1.00 46.39 ? 318 GLU A CA  1 
ATOM   2257 C C   . GLU A 1 291 ? 46.087 -46.109 -32.037 1.00 47.63 ? 318 GLU A C   1 
ATOM   2258 O O   . GLU A 1 291 ? 46.826 -46.995 -32.474 1.00 48.61 ? 318 GLU A O   1 
ATOM   2259 C CB  . GLU A 1 291 ? 45.537 -46.352 -29.562 1.00 48.16 ? 318 GLU A CB  1 
ATOM   2260 C CG  . GLU A 1 291 ? 46.110 -46.181 -28.152 1.00 53.78 ? 318 GLU A CG  1 
ATOM   2261 C CD  . GLU A 1 291 ? 45.361 -46.855 -27.003 1.00 54.18 ? 318 GLU A CD  1 
ATOM   2262 O OE1 . GLU A 1 291 ? 45.821 -46.765 -25.841 1.00 56.41 ? 318 GLU A OE1 1 
ATOM   2263 O OE2 . GLU A 1 291 ? 44.324 -47.489 -27.247 1.00 53.73 ? 318 GLU A OE2 1 
ATOM   2264 N N   . VAL A 1 292 ? 45.052 -45.622 -32.741 1.00 40.85 ? 319 VAL A N   1 
ATOM   2265 C CA  . VAL A 1 292 ? 44.685 -46.222 -34.025 1.00 40.92 ? 319 VAL A CA  1 
ATOM   2266 C C   . VAL A 1 292 ? 44.792 -45.248 -35.196 1.00 40.55 ? 319 VAL A C   1 
ATOM   2267 O O   . VAL A 1 292 ? 44.680 -45.693 -36.341 1.00 37.97 ? 319 VAL A O   1 
ATOM   2268 C CB  . VAL A 1 292 ? 43.284 -46.860 -34.015 1.00 40.73 ? 319 VAL A CB  1 
ATOM   2269 C CG1 . VAL A 1 292 ? 43.210 -47.985 -32.988 1.00 42.66 ? 319 VAL A CG1 1 
ATOM   2270 C CG2 . VAL A 1 292 ? 42.161 -45.838 -33.831 1.00 36.77 ? 319 VAL A CG2 1 
ATOM   2271 N N   . GLY A 1 293 ? 44.944 -43.943 -34.916 1.00 41.79 ? 320 GLY A N   1 
ATOM   2272 C CA  . GLY A 1 293 ? 45.150 -42.932 -35.941 1.00 45.40 ? 320 GLY A CA  1 
ATOM   2273 C C   . GLY A 1 293 ? 43.960 -41.974 -36.072 1.00 49.14 ? 320 GLY A C   1 
ATOM   2274 O O   . GLY A 1 293 ? 42.807 -42.360 -35.863 1.00 44.95 ? 320 GLY A O   1 
ATOM   2275 N N   . LYS A 1 294 ? 44.285 -40.738 -36.478 1.00 52.42 ? 321 LYS A N   1 
ATOM   2276 C CA  . LYS A 1 294 ? 43.381 -39.598 -36.453 1.00 59.98 ? 321 LYS A CA  1 
ATOM   2277 C C   . LYS A 1 294 ? 42.341 -39.719 -37.559 1.00 56.70 ? 321 LYS A C   1 
ATOM   2278 O O   . LYS A 1 294 ? 41.303 -39.071 -37.500 1.00 63.28 ? 321 LYS A O   1 
ATOM   2279 C CB  . LYS A 1 294 ? 44.155 -38.281 -36.624 1.00 64.54 ? 321 LYS A CB  1 
ATOM   2280 C CG  . LYS A 1 294 ? 43.400 -37.018 -36.196 1.00 66.88 ? 321 LYS A CG  1 
ATOM   2281 C CD  . LYS A 1 294 ? 44.010 -35.692 -36.640 1.00 71.01 ? 321 LYS A CD  1 
ATOM   2282 C CE  . LYS A 1 294 ? 45.476 -35.558 -36.345 1.00 71.81 ? 321 LYS A CE  1 
ATOM   2283 N NZ  . LYS A 1 294 ? 45.750 -35.526 -34.907 1.00 74.61 ? 321 LYS A NZ  1 
ATOM   2284 N N   . ASP A 1 295 ? 42.642 -40.531 -38.574 1.00 63.26 ? 322 ASP A N   1 
ATOM   2285 C CA  . ASP A 1 295 ? 41.690 -40.849 -39.620 1.00 64.31 ? 322 ASP A CA  1 
ATOM   2286 C C   . ASP A 1 295 ? 41.493 -42.353 -39.620 1.00 60.58 ? 322 ASP A C   1 
ATOM   2287 O O   . ASP A 1 295 ? 42.468 -43.094 -39.701 1.00 59.71 ? 322 ASP A O   1 
ATOM   2288 C CB  . ASP A 1 295 ? 42.183 -40.382 -40.979 1.00 66.61 ? 322 ASP A CB  1 
ATOM   2289 C CG  . ASP A 1 295 ? 41.893 -38.926 -41.306 1.00 63.94 ? 322 ASP A CG  1 
ATOM   2290 O OD1 . ASP A 1 295 ? 40.703 -38.601 -41.513 1.00 66.49 ? 322 ASP A OD1 1 
ATOM   2291 O OD2 . ASP A 1 295 ? 42.857 -38.138 -41.349 1.00 56.70 ? 322 ASP A OD2 1 
ATOM   2292 N N   . VAL A 1 296 ? 40.242 -42.797 -39.542 1.00 60.32 ? 323 VAL A N   1 
ATOM   2293 C CA  . VAL A 1 296 ? 40.006 -44.226 -39.425 1.00 61.78 ? 323 VAL A CA  1 
ATOM   2294 C C   . VAL A 1 296 ? 38.720 -44.590 -40.154 1.00 62.00 ? 323 VAL A C   1 
ATOM   2295 O O   . VAL A 1 296 ? 37.774 -43.805 -40.207 1.00 64.37 ? 323 VAL A O   1 
ATOM   2296 C CB  . VAL A 1 296 ? 39.998 -44.707 -37.956 1.00 60.90 ? 323 VAL A CB  1 
ATOM   2297 C CG1 . VAL A 1 296 ? 38.723 -44.315 -37.205 1.00 62.62 ? 323 VAL A CG1 1 
ATOM   2298 C CG2 . VAL A 1 296 ? 40.237 -46.207 -37.853 1.00 58.18 ? 323 VAL A CG2 1 
ATOM   2299 N N   . SER A 1 297 ? 38.727 -45.799 -40.720 1.00 69.69 ? 324 SER A N   1 
ATOM   2300 C CA  . SER A 1 297 ? 37.532 -46.419 -41.263 1.00 72.53 ? 324 SER A CA  1 
ATOM   2301 C C   . SER A 1 297 ? 36.729 -47.005 -40.110 1.00 65.00 ? 324 SER A C   1 
ATOM   2302 O O   . SER A 1 297 ? 37.254 -47.200 -39.020 1.00 53.26 ? 324 SER A O   1 
ATOM   2303 C CB  . SER A 1 297 ? 37.863 -47.479 -42.291 1.00 77.17 ? 324 SER A CB  1 
ATOM   2304 O OG  . SER A 1 297 ? 38.597 -46.939 -43.383 1.00 76.79 ? 324 SER A OG  1 
ATOM   2305 N N   . ASP A 1 298 ? 35.464 -47.322 -40.389 1.00 65.38 ? 325 ASP A N   1 
ATOM   2306 C CA  . ASP A 1 298 ? 34.502 -47.666 -39.356 1.00 65.36 ? 325 ASP A CA  1 
ATOM   2307 C C   . ASP A 1 298 ? 34.737 -49.084 -38.836 1.00 60.87 ? 325 ASP A C   1 
ATOM   2308 O O   . ASP A 1 298 ? 34.067 -49.529 -37.902 1.00 64.57 ? 325 ASP A O   1 
ATOM   2309 C CB  . ASP A 1 298 ? 33.087 -47.513 -39.892 1.00 64.34 ? 325 ASP A CB  1 
ATOM   2310 C CG  . ASP A 1 298 ? 32.730 -46.162 -40.501 1.00 65.13 ? 325 ASP A CG  1 
ATOM   2311 O OD1 . ASP A 1 298 ? 33.379 -45.150 -40.152 1.00 70.80 ? 325 ASP A OD1 1 
ATOM   2312 O OD2 . ASP A 1 298 ? 31.818 -46.135 -41.346 1.00 58.13 ? 325 ASP A OD2 1 
ATOM   2313 N N   . GLU A 1 299 ? 35.683 -49.796 -39.456 1.00 67.21 ? 326 GLU A N   1 
ATOM   2314 C CA  . GLU A 1 299 ? 35.914 -51.207 -39.180 1.00 68.91 ? 326 GLU A CA  1 
ATOM   2315 C C   . GLU A 1 299 ? 36.935 -51.376 -38.051 1.00 58.85 ? 326 GLU A C   1 
ATOM   2316 O O   . GLU A 1 299 ? 36.709 -52.155 -37.120 1.00 45.08 ? 326 GLU A O   1 
ATOM   2317 C CB  . GLU A 1 299 ? 36.316 -51.834 -40.518 1.00 74.95 ? 326 GLU A CB  1 
ATOM   2318 C CG  . GLU A 1 299 ? 37.184 -53.086 -40.404 1.00 76.94 ? 326 GLU A CG  1 
ATOM   2319 C CD  . GLU A 1 299 ? 37.688 -53.609 -41.738 1.00 72.66 ? 326 GLU A CD  1 
ATOM   2320 O OE1 . GLU A 1 299 ? 37.133 -53.233 -42.802 1.00 68.10 ? 326 GLU A OE1 1 
ATOM   2321 O OE2 . GLU A 1 299 ? 38.677 -54.371 -41.700 1.00 69.40 ? 326 GLU A OE2 1 
ATOM   2322 N N   . LYS A 1 300 ? 38.075 -50.679 -38.182 1.00 60.03 ? 327 LYS A N   1 
ATOM   2323 C CA  . LYS A 1 300 ? 39.058 -50.551 -37.115 1.00 62.49 ? 327 LYS A CA  1 
ATOM   2324 C C   . LYS A 1 300 ? 38.382 -50.010 -35.857 1.00 65.73 ? 327 LYS A C   1 
ATOM   2325 O O   . LYS A 1 300 ? 38.501 -50.586 -34.776 1.00 62.04 ? 327 LYS A O   1 
ATOM   2326 C CB  . LYS A 1 300 ? 40.168 -49.570 -37.512 1.00 66.98 ? 327 LYS A CB  1 
ATOM   2327 C CG  . LYS A 1 300 ? 41.484 -50.154 -38.036 1.00 70.00 ? 327 LYS A CG  1 
ATOM   2328 C CD  . LYS A 1 300 ? 42.561 -50.381 -36.979 1.00 65.92 ? 327 LYS A CD  1 
ATOM   2329 C CE  . LYS A 1 300 ? 43.948 -50.552 -37.547 1.00 65.12 ? 327 LYS A CE  1 
ATOM   2330 N NZ  . LYS A 1 300 ? 44.531 -49.340 -38.143 1.00 60.98 ? 327 LYS A NZ  1 
ATOM   2331 N N   . LEU A 1 301 ? 37.657 -48.896 -36.021 1.00 68.11 ? 328 LEU A N   1 
ATOM   2332 C CA  . LEU A 1 301 ? 37.029 -48.211 -34.902 1.00 62.15 ? 328 LEU A CA  1 
ATOM   2333 C C   . LEU A 1 301 ? 36.158 -49.179 -34.113 1.00 53.82 ? 328 LEU A C   1 
ATOM   2334 O O   . LEU A 1 301 ? 36.058 -49.049 -32.901 1.00 60.67 ? 328 LEU A O   1 
ATOM   2335 C CB  . LEU A 1 301 ? 36.214 -47.012 -35.390 1.00 59.62 ? 328 LEU A CB  1 
ATOM   2336 C CG  . LEU A 1 301 ? 35.594 -46.150 -34.284 1.00 59.93 ? 328 LEU A CG  1 
ATOM   2337 C CD1 . LEU A 1 301 ? 36.684 -45.600 -33.379 1.00 55.18 ? 328 LEU A CD1 1 
ATOM   2338 C CD2 . LEU A 1 301 ? 34.760 -45.018 -34.854 1.00 58.06 ? 328 LEU A CD2 1 
ATOM   2339 N N   . ARG A 1 302 ? 35.542 -50.147 -34.807 1.00 54.45 ? 329 ARG A N   1 
ATOM   2340 C CA  . ARG A 1 302 ? 34.649 -51.115 -34.180 1.00 56.57 ? 329 ARG A CA  1 
ATOM   2341 C C   . ARG A 1 302 ? 35.424 -52.100 -33.305 1.00 55.69 ? 329 ARG A C   1 
ATOM   2342 O O   . ARG A 1 302 ? 34.869 -52.628 -32.342 1.00 61.76 ? 329 ARG A O   1 
ATOM   2343 C CB  . ARG A 1 302 ? 33.814 -51.871 -35.229 1.00 63.20 ? 329 ARG A CB  1 
ATOM   2344 C CG  . ARG A 1 302 ? 32.776 -52.850 -34.680 1.00 65.43 ? 329 ARG A CG  1 
ATOM   2345 C CD  . ARG A 1 302 ? 31.946 -53.568 -35.759 1.00 66.40 ? 329 ARG A CD  1 
ATOM   2346 N NE  . ARG A 1 302 ? 31.064 -52.673 -36.519 1.00 66.51 ? 329 ARG A NE  1 
ATOM   2347 C CZ  . ARG A 1 302 ? 31.141 -52.325 -37.812 1.00 70.31 ? 329 ARG A CZ  1 
ATOM   2348 N NH1 . ARG A 1 302 ? 32.037 -52.870 -38.621 1.00 73.23 ? 329 ARG A NH1 1 
ATOM   2349 N NH2 . ARG A 1 302 ? 30.302 -51.421 -38.303 1.00 66.32 ? 329 ARG A NH2 1 
ATOM   2350 N N   . ASP A 1 303 ? 36.691 -52.364 -33.659 1.00 65.85 ? 330 ASP A N   1 
ATOM   2351 C CA  . ASP A 1 303 ? 37.515 -53.358 -32.975 1.00 64.76 ? 330 ASP A CA  1 
ATOM   2352 C C   . ASP A 1 303 ? 38.126 -52.759 -31.707 1.00 54.74 ? 330 ASP A C   1 
ATOM   2353 O O   . ASP A 1 303 ? 38.367 -53.469 -30.737 1.00 49.64 ? 330 ASP A O   1 
ATOM   2354 C CB  . ASP A 1 303 ? 38.634 -53.891 -33.862 1.00 66.57 ? 330 ASP A CB  1 
ATOM   2355 C CG  . ASP A 1 303 ? 38.330 -54.041 -35.350 1.00 70.63 ? 330 ASP A CG  1 
ATOM   2356 O OD1 . ASP A 1 303 ? 37.193 -53.709 -35.777 1.00 71.11 ? 330 ASP A OD1 1 
ATOM   2357 O OD2 . ASP A 1 303 ? 39.246 -54.468 -36.081 1.00 67.51 ? 330 ASP A OD2 1 
ATOM   2358 N N   . TYR A 1 304 ? 38.411 -51.452 -31.748 1.00 52.92 ? 331 TYR A N   1 
ATOM   2359 C CA  . TYR A 1 304 ? 38.916 -50.723 -30.594 1.00 52.49 ? 331 TYR A CA  1 
ATOM   2360 C C   . TYR A 1 304 ? 37.914 -50.769 -29.434 1.00 52.06 ? 331 TYR A C   1 
ATOM   2361 O O   . TYR A 1 304 ? 38.291 -51.065 -28.296 1.00 48.47 ? 331 TYR A O   1 
ATOM   2362 C CB  . TYR A 1 304 ? 39.251 -49.299 -31.053 1.00 51.15 ? 331 TYR A CB  1 
ATOM   2363 C CG  . TYR A 1 304 ? 40.002 -48.497 -30.003 1.00 50.07 ? 331 TYR A CG  1 
ATOM   2364 C CD1 . TYR A 1 304 ? 39.328 -47.909 -28.937 1.00 52.07 ? 331 TYR A CD1 1 
ATOM   2365 C CD2 . TYR A 1 304 ? 41.381 -48.361 -30.053 1.00 46.26 ? 331 TYR A CD2 1 
ATOM   2366 C CE1 . TYR A 1 304 ? 39.999 -47.188 -27.965 1.00 49.40 ? 331 TYR A CE1 1 
ATOM   2367 C CE2 . TYR A 1 304 ? 42.066 -47.647 -29.083 1.00 46.53 ? 331 TYR A CE2 1 
ATOM   2368 C CZ  . TYR A 1 304 ? 41.371 -47.052 -28.043 1.00 46.94 ? 331 TYR A CZ  1 
ATOM   2369 O OH  . TYR A 1 304 ? 41.997 -46.336 -27.075 1.00 47.21 ? 331 TYR A OH  1 
ATOM   2370 N N   . ILE A 1 305 ? 36.633 -50.490 -29.726 1.00 54.25 ? 332 ILE A N   1 
ATOM   2371 C CA  . ILE A 1 305 ? 35.593 -50.522 -28.705 1.00 52.94 ? 332 ILE A CA  1 
ATOM   2372 C C   . ILE A 1 305 ? 35.680 -51.857 -27.965 1.00 54.74 ? 332 ILE A C   1 
ATOM   2373 O O   . ILE A 1 305 ? 35.727 -51.908 -26.731 1.00 49.89 ? 332 ILE A O   1 
ATOM   2374 C CB  . ILE A 1 305 ? 34.182 -50.306 -29.299 1.00 54.97 ? 332 ILE A CB  1 
ATOM   2375 C CG1 . ILE A 1 305 ? 34.110 -49.158 -30.326 1.00 51.51 ? 332 ILE A CG1 1 
ATOM   2376 C CG2 . ILE A 1 305 ? 33.154 -50.125 -28.183 1.00 52.67 ? 332 ILE A CG2 1 
ATOM   2377 C CD1 . ILE A 1 305 ? 34.763 -47.862 -29.885 1.00 51.44 ? 332 ILE A CD1 1 
ATOM   2378 N N   . TRP A 1 306 ? 35.732 -52.938 -28.749 1.00 56.91 ? 333 TRP A N   1 
ATOM   2379 C CA  . TRP A 1 306 ? 35.751 -54.289 -28.216 1.00 56.24 ? 333 TRP A CA  1 
ATOM   2380 C C   . TRP A 1 306 ? 36.901 -54.500 -27.243 1.00 57.35 ? 333 TRP A C   1 
ATOM   2381 O O   . TRP A 1 306 ? 36.690 -55.058 -26.167 1.00 53.57 ? 333 TRP A O   1 
ATOM   2382 C CB  . TRP A 1 306 ? 35.798 -55.299 -29.370 1.00 60.05 ? 333 TRP A CB  1 
ATOM   2383 C CG  . TRP A 1 306 ? 34.414 -55.717 -29.782 1.00 62.23 ? 333 TRP A CG  1 
ATOM   2384 C CD1 . TRP A 1 306 ? 33.845 -55.664 -31.022 1.00 59.02 ? 333 TRP A CD1 1 
ATOM   2385 C CD2 . TRP A 1 306 ? 33.410 -56.252 -28.891 1.00 55.52 ? 333 TRP A CD2 1 
ATOM   2386 N NE1 . TRP A 1 306 ? 32.556 -56.124 -30.963 1.00 58.61 ? 333 TRP A NE1 1 
ATOM   2387 C CE2 . TRP A 1 306 ? 32.263 -56.495 -29.673 1.00 57.47 ? 333 TRP A CE2 1 
ATOM   2388 C CE3 . TRP A 1 306 ? 33.373 -56.543 -27.521 1.00 54.23 ? 333 TRP A CE3 1 
ATOM   2389 C CZ2 . TRP A 1 306 ? 31.097 -57.022 -29.122 1.00 52.89 ? 333 TRP A CZ2 1 
ATOM   2390 C CZ3 . TRP A 1 306 ? 32.220 -57.067 -26.982 1.00 53.33 ? 333 TRP A CZ3 1 
ATOM   2391 C CH2 . TRP A 1 306 ? 31.100 -57.307 -27.775 1.00 53.89 ? 333 TRP A CH2 1 
ATOM   2392 N N   . ASN A 1 307 ? 38.099 -54.043 -27.633 1.00 66.83 ? 334 ASN A N   1 
ATOM   2393 C CA  . ASN A 1 307 ? 39.276 -54.104 -26.777 1.00 68.81 ? 334 ASN A CA  1 
ATOM   2394 C C   . ASN A 1 307 ? 39.007 -53.364 -25.475 1.00 66.46 ? 334 ASN A C   1 
ATOM   2395 O O   . ASN A 1 307 ? 39.251 -53.895 -24.392 1.00 68.92 ? 334 ASN A O   1 
ATOM   2396 C CB  . ASN A 1 307 ? 40.504 -53.467 -27.419 1.00 75.71 ? 334 ASN A CB  1 
ATOM   2397 C CG  . ASN A 1 307 ? 40.921 -54.146 -28.701 1.00 82.43 ? 334 ASN A CG  1 
ATOM   2398 O OD1 . ASN A 1 307 ? 41.843 -53.669 -29.372 1.00 88.81 ? 334 ASN A OD1 1 
ATOM   2399 N ND2 . ASN A 1 307 ? 40.271 -55.245 -29.062 1.00 81.70 ? 334 ASN A ND2 1 
ATOM   2400 N N   . THR A 1 308 ? 38.508 -52.129 -25.607 1.00 61.74 ? 335 THR A N   1 
ATOM   2401 C CA  . THR A 1 308 ? 38.152 -51.320 -24.454 1.00 59.30 ? 335 THR A CA  1 
ATOM   2402 C C   . THR A 1 308 ? 37.344 -52.180 -23.488 1.00 54.33 ? 335 THR A C   1 
ATOM   2403 O O   . THR A 1 308 ? 37.664 -52.267 -22.299 1.00 48.95 ? 335 THR A O   1 
ATOM   2404 C CB  . THR A 1 308 ? 37.365 -50.081 -24.893 1.00 57.91 ? 335 THR A CB  1 
ATOM   2405 O OG1 . THR A 1 308 ? 37.916 -49.632 -26.126 1.00 60.60 ? 335 THR A OG1 1 
ATOM   2406 C CG2 . THR A 1 308 ? 37.439 -48.952 -23.884 1.00 59.43 ? 335 THR A CG2 1 
ATOM   2407 N N   . LEU A 1 309 ? 36.300 -52.824 -24.032 1.00 55.54 ? 336 LEU A N   1 
ATOM   2408 C CA  . LEU A 1 309 ? 35.329 -53.556 -23.230 1.00 55.09 ? 336 LEU A CA  1 
ATOM   2409 C C   . LEU A 1 309 ? 35.942 -54.834 -22.661 1.00 51.84 ? 336 LEU A C   1 
ATOM   2410 O O   . LEU A 1 309 ? 35.787 -55.116 -21.476 1.00 50.52 ? 336 LEU A O   1 
ATOM   2411 C CB  . LEU A 1 309 ? 34.090 -53.838 -24.078 1.00 57.66 ? 336 LEU A CB  1 
ATOM   2412 C CG  . LEU A 1 309 ? 33.314 -52.603 -24.546 1.00 59.19 ? 336 LEU A CG  1 
ATOM   2413 C CD1 . LEU A 1 309 ? 32.183 -52.999 -25.469 1.00 62.63 ? 336 LEU A CD1 1 
ATOM   2414 C CD2 . LEU A 1 309 ? 32.780 -51.806 -23.366 1.00 59.02 ? 336 LEU A CD2 1 
ATOM   2415 N N   . ASN A 1 310 ? 36.689 -55.574 -23.488 1.00 56.99 ? 337 ASN A N   1 
ATOM   2416 C CA  . ASN A 1 310 ? 37.363 -56.780 -23.019 1.00 58.52 ? 337 ASN A CA  1 
ATOM   2417 C C   . ASN A 1 310 ? 38.360 -56.444 -21.909 1.00 63.04 ? 337 ASN A C   1 
ATOM   2418 O O   . ASN A 1 310 ? 38.579 -57.258 -21.011 1.00 65.81 ? 337 ASN A O   1 
ATOM   2419 C CB  . ASN A 1 310 ? 38.013 -57.542 -24.167 1.00 57.56 ? 337 ASN A CB  1 
ATOM   2420 C CG  . ASN A 1 310 ? 36.994 -57.897 -25.219 1.00 60.69 ? 337 ASN A CG  1 
ATOM   2421 O OD1 . ASN A 1 310 ? 35.882 -58.327 -24.891 1.00 59.59 ? 337 ASN A OD1 1 
ATOM   2422 N ND2 . ASN A 1 310 ? 37.328 -57.667 -26.480 1.00 68.60 ? 337 ASN A ND2 1 
ATOM   2423 N N   . SER A 1 311 ? 38.939 -55.235 -21.942 1.00 57.70 ? 338 SER A N   1 
ATOM   2424 C CA  . SER A 1 311 ? 39.844 -54.817 -20.884 1.00 60.68 ? 338 SER A CA  1 
ATOM   2425 C C   . SER A 1 311 ? 39.088 -54.563 -19.576 1.00 64.22 ? 338 SER A C   1 
ATOM   2426 O O   . SER A 1 311 ? 39.700 -54.411 -18.520 1.00 55.00 ? 338 SER A O   1 
ATOM   2427 C CB  . SER A 1 311 ? 40.633 -53.609 -21.294 1.00 66.71 ? 338 SER A CB  1 
ATOM   2428 O OG  . SER A 1 311 ? 41.565 -53.257 -20.280 1.00 74.45 ? 338 SER A OG  1 
ATOM   2429 N N   . GLY A 1 312 ? 37.753 -54.528 -19.630 1.00 63.04 ? 339 GLY A N   1 
ATOM   2430 C CA  . GLY A 1 312 ? 36.973 -54.180 -18.456 1.00 61.29 ? 339 GLY A CA  1 
ATOM   2431 C C   . GLY A 1 312 ? 36.985 -52.671 -18.218 1.00 55.42 ? 339 GLY A C   1 
ATOM   2432 O O   . GLY A 1 312 ? 37.000 -52.229 -17.074 1.00 57.88 ? 339 GLY A O   1 
ATOM   2433 N N   . ARG A 1 313 ? 36.966 -51.888 -19.304 1.00 52.94 ? 340 ARG A N   1 
ATOM   2434 C CA  . ARG A 1 313 ? 36.888 -50.437 -19.206 1.00 54.17 ? 340 ARG A CA  1 
ATOM   2435 C C   . ARG A 1 313 ? 35.667 -49.933 -19.976 1.00 47.95 ? 340 ARG A C   1 
ATOM   2436 O O   . ARG A 1 313 ? 35.264 -50.520 -20.979 1.00 41.98 ? 340 ARG A O   1 
ATOM   2437 C CB  . ARG A 1 313 ? 38.175 -49.784 -19.721 1.00 54.83 ? 340 ARG A CB  1 
ATOM   2438 C CG  . ARG A 1 313 ? 39.467 -50.429 -19.237 1.00 59.34 ? 340 ARG A CG  1 
ATOM   2439 C CD  . ARG A 1 313 ? 40.685 -49.517 -19.374 1.00 60.85 ? 340 ARG A CD  1 
ATOM   2440 N NE  . ARG A 1 313 ? 40.678 -48.758 -20.630 1.00 63.08 ? 340 ARG A NE  1 
ATOM   2441 C CZ  . ARG A 1 313 ? 41.008 -49.176 -21.856 1.00 68.61 ? 340 ARG A CZ  1 
ATOM   2442 N NH1 . ARG A 1 313 ? 40.637 -48.455 -22.904 1.00 61.87 ? 340 ARG A NH1 1 
ATOM   2443 N NH2 . ARG A 1 313 ? 41.639 -50.327 -22.041 1.00 70.88 ? 340 ARG A NH2 1 
ATOM   2444 N N   . VAL A 1 314 ? 35.098 -48.810 -19.517 1.00 46.80 ? 341 VAL A N   1 
ATOM   2445 C CA  . VAL A 1 314 ? 33.846 -48.322 -20.076 1.00 43.73 ? 341 VAL A CA  1 
ATOM   2446 C C   . VAL A 1 314 ? 34.166 -47.524 -21.326 1.00 41.97 ? 341 VAL A C   1 
ATOM   2447 O O   . VAL A 1 314 ? 35.297 -47.093 -21.518 1.00 41.58 ? 341 VAL A O   1 
ATOM   2448 C CB  . VAL A 1 314 ? 32.997 -47.486 -19.095 1.00 44.91 ? 341 VAL A CB  1 
ATOM   2449 C CG1 . VAL A 1 314 ? 32.548 -48.322 -17.907 1.00 43.56 ? 341 VAL A CG1 1 
ATOM   2450 C CG2 . VAL A 1 314 ? 33.704 -46.207 -18.631 1.00 46.23 ? 341 VAL A CG2 1 
ATOM   2451 N N   . VAL A 1 315 ? 33.158 -47.346 -22.180 1.00 41.04 ? 342 VAL A N   1 
ATOM   2452 C CA  . VAL A 1 315 ? 33.233 -46.346 -23.227 1.00 36.87 ? 342 VAL A CA  1 
ATOM   2453 C C   . VAL A 1 315 ? 32.608 -45.090 -22.645 1.00 37.39 ? 342 VAL A C   1 
ATOM   2454 O O   . VAL A 1 315 ? 31.406 -45.065 -22.389 1.00 34.56 ? 342 VAL A O   1 
ATOM   2455 C CB  . VAL A 1 315 ? 32.524 -46.801 -24.512 1.00 39.04 ? 342 VAL A CB  1 
ATOM   2456 C CG1 . VAL A 1 315 ? 32.618 -45.774 -25.636 1.00 37.32 ? 342 VAL A CG1 1 
ATOM   2457 C CG2 . VAL A 1 315 ? 33.057 -48.146 -24.977 1.00 40.56 ? 342 VAL A CG2 1 
ATOM   2458 N N   . PRO A 1 316 ? 33.401 -44.031 -22.369 1.00 36.60 ? 343 PRO A N   1 
ATOM   2459 C CA  . PRO A 1 316 ? 32.869 -42.852 -21.690 1.00 34.15 ? 343 PRO A CA  1 
ATOM   2460 C C   . PRO A 1 316 ? 31.885 -42.164 -22.627 1.00 34.47 ? 343 PRO A C   1 
ATOM   2461 O O   . PRO A 1 316 ? 32.077 -42.158 -23.849 1.00 30.88 ? 343 PRO A O   1 
ATOM   2462 C CB  . PRO A 1 316 ? 34.096 -41.993 -21.400 1.00 30.66 ? 343 PRO A CB  1 
ATOM   2463 C CG  . PRO A 1 316 ? 35.067 -42.389 -22.484 1.00 32.36 ? 343 PRO A CG  1 
ATOM   2464 C CD  . PRO A 1 316 ? 34.810 -43.870 -22.753 1.00 33.64 ? 343 PRO A CD  1 
ATOM   2465 N N   . GLY A 1 317 ? 30.840 -41.589 -22.023 1.00 32.76 ? 344 GLY A N   1 
ATOM   2466 C CA  . GLY A 1 317 ? 29.884 -40.780 -22.759 1.00 35.94 ? 344 GLY A CA  1 
ATOM   2467 C C   . GLY A 1 317 ? 28.702 -41.606 -23.259 1.00 31.45 ? 344 GLY A C   1 
ATOM   2468 O O   . GLY A 1 317 ? 27.802 -41.041 -23.858 1.00 33.38 ? 344 GLY A O   1 
ATOM   2469 N N   . TYR A 1 318 ? 28.711 -42.913 -22.970 1.00 32.34 ? 345 TYR A N   1 
ATOM   2470 C CA  . TYR A 1 318 ? 27.618 -43.825 -23.282 1.00 33.90 ? 345 TYR A CA  1 
ATOM   2471 C C   . TYR A 1 318 ? 27.069 -44.365 -21.966 1.00 35.25 ? 345 TYR A C   1 
ATOM   2472 O O   . TYR A 1 318 ? 27.822 -44.614 -21.027 1.00 34.26 ? 345 TYR A O   1 
ATOM   2473 C CB  . TYR A 1 318 ? 28.107 -44.907 -24.257 1.00 31.58 ? 345 TYR A CB  1 
ATOM   2474 C CG  . TYR A 1 318 ? 28.288 -44.340 -25.656 1.00 33.73 ? 345 TYR A CG  1 
ATOM   2475 C CD1 . TYR A 1 318 ? 29.382 -43.539 -25.963 1.00 30.89 ? 345 TYR A CD1 1 
ATOM   2476 C CD2 . TYR A 1 318 ? 27.314 -44.505 -26.637 1.00 31.54 ? 345 TYR A CD2 1 
ATOM   2477 C CE1 . TYR A 1 318 ? 29.518 -42.954 -27.209 1.00 31.71 ? 345 TYR A CE1 1 
ATOM   2478 C CE2 . TYR A 1 318 ? 27.437 -43.918 -27.885 1.00 33.47 ? 345 TYR A CE2 1 
ATOM   2479 C CZ  . TYR A 1 318 ? 28.552 -43.160 -28.183 1.00 35.36 ? 345 TYR A CZ  1 
ATOM   2480 O OH  . TYR A 1 318 ? 28.692 -42.566 -29.416 1.00 35.02 ? 345 TYR A OH  1 
ATOM   2481 N N   . GLY A 1 319 ? 25.738 -44.506 -21.893 1.00 37.50 ? 346 GLY A N   1 
ATOM   2482 C CA  . GLY A 1 319 ? 25.088 -44.987 -20.685 1.00 36.14 ? 346 GLY A CA  1 
ATOM   2483 C C   . GLY A 1 319 ? 24.488 -43.846 -19.870 1.00 38.87 ? 346 GLY A C   1 
ATOM   2484 O O   . GLY A 1 319 ? 24.785 -42.664 -20.109 1.00 37.89 ? 346 GLY A O   1 
ATOM   2485 N N   . HIS A 1 320 ? 23.611 -44.223 -18.932 1.00 40.56 ? 347 HIS A N   1 
ATOM   2486 C CA  . HIS A 1 320 ? 23.074 -43.305 -17.936 1.00 44.30 ? 347 HIS A CA  1 
ATOM   2487 C C   . HIS A 1 320 ? 22.435 -44.102 -16.808 1.00 45.54 ? 347 HIS A C   1 
ATOM   2488 O O   . HIS A 1 320 ? 21.935 -45.203 -17.039 1.00 51.29 ? 347 HIS A O   1 
ATOM   2489 C CB  . HIS A 1 320 ? 22.011 -42.365 -18.518 1.00 44.56 ? 347 HIS A CB  1 
ATOM   2490 C CG  . HIS A 1 320 ? 21.760 -41.140 -17.694 1.00 46.95 ? 347 HIS A CG  1 
ATOM   2491 N ND1 . HIS A 1 320 ? 20.845 -41.079 -16.663 1.00 47.15 ? 347 HIS A ND1 1 
ATOM   2492 C CD2 . HIS A 1 320 ? 22.331 -39.926 -17.755 1.00 45.43 ? 347 HIS A CD2 1 
ATOM   2493 C CE1 . HIS A 1 320 ? 20.876 -39.867 -16.124 1.00 49.99 ? 347 HIS A CE1 1 
ATOM   2494 N NE2 . HIS A 1 320 ? 21.769 -39.149 -16.777 1.00 46.24 ? 347 HIS A NE2 1 
ATOM   2495 N N   . ALA A 1 321 ? 22.410 -43.497 -15.610 1.00 48.00 ? 348 ALA A N   1 
ATOM   2496 C CA  . ALA A 1 321 ? 21.879 -44.130 -14.411 1.00 50.14 ? 348 ALA A CA  1 
ATOM   2497 C C   . ALA A 1 321 ? 20.399 -44.511 -14.562 1.00 53.21 ? 348 ALA A C   1 
ATOM   2498 O O   . ALA A 1 321 ? 19.987 -45.559 -14.067 1.00 50.11 ? 348 ALA A O   1 
ATOM   2499 C CB  . ALA A 1 321 ? 22.102 -43.217 -13.223 1.00 53.55 ? 348 ALA A CB  1 
ATOM   2500 N N   . VAL A 1 322 ? 19.606 -43.658 -15.232 1.00 52.37 ? 349 VAL A N   1 
ATOM   2501 C CA  . VAL A 1 322 ? 18.150 -43.766 -15.235 1.00 51.24 ? 349 VAL A CA  1 
ATOM   2502 C C   . VAL A 1 322 ? 17.644 -43.740 -16.679 1.00 48.17 ? 349 VAL A C   1 
ATOM   2503 O O   . VAL A 1 322 ? 16.809 -44.559 -17.031 1.00 52.36 ? 349 VAL A O   1 
ATOM   2504 C CB  . VAL A 1 322 ? 17.431 -42.750 -14.303 1.00 53.24 ? 349 VAL A CB  1 
ATOM   2505 C CG1 . VAL A 1 322 ? 18.315 -41.601 -13.826 1.00 57.53 ? 349 VAL A CG1 1 
ATOM   2506 C CG2 . VAL A 1 322 ? 16.125 -42.203 -14.872 1.00 59.07 ? 349 VAL A CG2 1 
ATOM   2507 N N   . LEU A 1 323 ? 18.183 -42.843 -17.514 1.00 46.50 ? 350 LEU A N   1 
ATOM   2508 C CA  . LEU A 1 323 ? 17.896 -42.769 -18.945 1.00 47.76 ? 350 LEU A CA  1 
ATOM   2509 C C   . LEU A 1 323 ? 18.134 -44.118 -19.628 1.00 55.46 ? 350 LEU A C   1 
ATOM   2510 O O   . LEU A 1 323 ? 18.987 -44.886 -19.193 1.00 57.70 ? 350 LEU A O   1 
ATOM   2511 C CB  . LEU A 1 323 ? 18.845 -41.694 -19.471 1.00 47.97 ? 350 LEU A CB  1 
ATOM   2512 C CG  . LEU A 1 323 ? 18.492 -40.929 -20.749 1.00 48.78 ? 350 LEU A CG  1 
ATOM   2513 C CD1 . LEU A 1 323 ? 17.033 -40.573 -20.900 1.00 48.33 ? 350 LEU A CD1 1 
ATOM   2514 C CD2 . LEU A 1 323 ? 19.346 -39.655 -20.735 1.00 46.23 ? 350 LEU A CD2 1 
ATOM   2515 N N   . ARG A 1 324 ? 17.400 -44.384 -20.718 1.00 56.16 ? 351 ARG A N   1 
ATOM   2516 C CA  . ARG A 1 324 ? 17.490 -45.659 -21.421 1.00 53.17 ? 351 ARG A CA  1 
ATOM   2517 C C   . ARG A 1 324 ? 17.367 -45.503 -22.942 1.00 47.96 ? 351 ARG A C   1 
ATOM   2518 O O   . ARG A 1 324 ? 17.044 -46.464 -23.634 1.00 55.14 ? 351 ARG A O   1 
ATOM   2519 C CB  . ARG A 1 324 ? 16.398 -46.607 -20.902 1.00 49.84 ? 351 ARG A CB  1 
ATOM   2520 C CG  . ARG A 1 324 ? 16.529 -47.090 -19.463 1.00 49.51 ? 351 ARG A CG  1 
ATOM   2521 C CD  . ARG A 1 324 ? 17.795 -47.902 -19.147 1.00 49.59 ? 351 ARG A CD  1 
ATOM   2522 N NE  . ARG A 1 324 ? 17.916 -48.189 -17.709 1.00 45.89 ? 351 ARG A NE  1 
ATOM   2523 C CZ  . ARG A 1 324 ? 18.718 -47.576 -16.842 1.00 50.30 ? 351 ARG A CZ  1 
ATOM   2524 N NH1 . ARG A 1 324 ? 18.597 -47.839 -15.550 1.00 51.35 ? 351 ARG A NH1 1 
ATOM   2525 N NH2 . ARG A 1 324 ? 19.594 -46.663 -17.238 1.00 51.55 ? 351 ARG A NH2 1 
ATOM   2526 N N   . LYS A 1 325 ? 17.623 -44.306 -23.474 1.00 46.99 ? 352 LYS A N   1 
ATOM   2527 C CA  . LYS A 1 325 ? 17.613 -44.069 -24.914 1.00 49.27 ? 352 LYS A CA  1 
ATOM   2528 C C   . LYS A 1 325 ? 18.602 -42.928 -25.175 1.00 45.96 ? 352 LYS A C   1 
ATOM   2529 O O   . LYS A 1 325 ? 19.233 -42.459 -24.237 1.00 48.57 ? 352 LYS A O   1 
ATOM   2530 C CB  . LYS A 1 325 ? 16.149 -43.898 -25.351 1.00 57.48 ? 352 LYS A CB  1 
ATOM   2531 C CG  . LYS A 1 325 ? 15.855 -43.158 -26.675 1.00 64.95 ? 352 LYS A CG  1 
ATOM   2532 C CD  . LYS A 1 325 ? 14.494 -43.446 -27.312 1.00 68.31 ? 352 LYS A CD  1 
ATOM   2533 C CE  . LYS A 1 325 ? 14.263 -42.746 -28.631 1.00 71.74 ? 352 LYS A CE  1 
ATOM   2534 N NZ  . LYS A 1 325 ? 13.043 -43.176 -29.335 1.00 69.24 ? 352 LYS A NZ  1 
ATOM   2535 N N   . THR A 1 326 ? 18.802 -42.513 -26.431 1.00 44.56 ? 353 THR A N   1 
ATOM   2536 C CA  . THR A 1 326 ? 19.730 -41.430 -26.710 1.00 46.85 ? 353 THR A CA  1 
ATOM   2537 C C   . THR A 1 326 ? 19.295 -40.194 -25.927 1.00 47.52 ? 353 THR A C   1 
ATOM   2538 O O   . THR A 1 326 ? 18.108 -39.938 -25.768 1.00 49.11 ? 353 THR A O   1 
ATOM   2539 C CB  . THR A 1 326 ? 19.835 -41.163 -28.210 1.00 45.70 ? 353 THR A CB  1 
ATOM   2540 O OG1 . THR A 1 326 ? 20.467 -42.323 -28.734 1.00 50.06 ? 353 THR A OG1 1 
ATOM   2541 C CG2 . THR A 1 326 ? 20.723 -39.980 -28.550 1.00 46.29 ? 353 THR A CG2 1 
ATOM   2542 N N   . ASP A 1 327 ? 20.278 -39.444 -25.421 1.00 45.31 ? 354 ASP A N   1 
ATOM   2543 C CA  . ASP A 1 327 ? 20.018 -38.286 -24.582 1.00 39.13 ? 354 ASP A CA  1 
ATOM   2544 C C   . ASP A 1 327 ? 19.706 -37.112 -25.498 1.00 34.35 ? 354 ASP A C   1 
ATOM   2545 O O   . ASP A 1 327 ? 20.519 -36.756 -26.349 1.00 36.38 ? 354 ASP A O   1 
ATOM   2546 C CB  . ASP A 1 327 ? 21.186 -38.055 -23.630 1.00 39.69 ? 354 ASP A CB  1 
ATOM   2547 C CG  . ASP A 1 327 ? 21.107 -36.900 -22.638 1.00 38.06 ? 354 ASP A CG  1 
ATOM   2548 O OD1 . ASP A 1 327 ? 20.047 -36.257 -22.538 1.00 33.73 ? 354 ASP A OD1 1 
ATOM   2549 O OD2 . ASP A 1 327 ? 22.127 -36.659 -21.949 1.00 39.74 ? 354 ASP A OD2 1 
ATOM   2550 N N   . PRO A 1 328 ? 18.543 -36.443 -25.321 1.00 31.80 ? 355 PRO A N   1 
ATOM   2551 C CA  . PRO A 1 328 ? 18.215 -35.259 -26.117 1.00 31.06 ? 355 PRO A CA  1 
ATOM   2552 C C   . PRO A 1 328 ? 19.213 -34.110 -25.990 1.00 29.20 ? 355 PRO A C   1 
ATOM   2553 O O   . PRO A 1 328 ? 19.396 -33.342 -26.919 1.00 29.98 ? 355 PRO A O   1 
ATOM   2554 C CB  . PRO A 1 328 ? 16.798 -34.854 -25.670 1.00 32.06 ? 355 PRO A CB  1 
ATOM   2555 C CG  . PRO A 1 328 ? 16.529 -35.643 -24.398 1.00 31.93 ? 355 PRO A CG  1 
ATOM   2556 C CD  . PRO A 1 328 ? 17.510 -36.788 -24.328 1.00 32.99 ? 355 PRO A CD  1 
ATOM   2557 N N   . ARG A 1 329 ? 19.921 -34.047 -24.861 1.00 30.19 ? 356 ARG A N   1 
ATOM   2558 C CA  . ARG A 1 329 ? 21.037 -33.137 -24.694 1.00 28.53 ? 356 ARG A CA  1 
ATOM   2559 C C   . ARG A 1 329 ? 22.179 -33.510 -25.642 1.00 30.25 ? 356 ARG A C   1 
ATOM   2560 O O   . ARG A 1 329 ? 22.887 -32.627 -26.116 1.00 33.71 ? 356 ARG A O   1 
ATOM   2561 C CB  . ARG A 1 329 ? 21.503 -33.180 -23.230 1.00 29.31 ? 356 ARG A CB  1 
ATOM   2562 C CG  . ARG A 1 329 ? 20.442 -32.690 -22.259 1.00 28.25 ? 356 ARG A CG  1 
ATOM   2563 C CD  . ARG A 1 329 ? 20.801 -32.806 -20.783 1.00 26.95 ? 356 ARG A CD  1 
ATOM   2564 N NE  . ARG A 1 329 ? 21.173 -34.173 -20.424 1.00 26.21 ? 356 ARG A NE  1 
ATOM   2565 C CZ  . ARG A 1 329 ? 21.745 -34.525 -19.287 1.00 27.85 ? 356 ARG A CZ  1 
ATOM   2566 N NH1 . ARG A 1 329 ? 21.917 -33.634 -18.326 1.00 26.61 ? 356 ARG A NH1 1 
ATOM   2567 N NH2 . ARG A 1 329 ? 22.096 -35.780 -19.099 1.00 26.80 ? 356 ARG A NH2 1 
ATOM   2568 N N   . TYR A 1 330 ? 22.363 -34.805 -25.929 1.00 28.11 ? 357 TYR A N   1 
ATOM   2569 C CA  . TYR A 1 330 ? 23.336 -35.199 -26.944 1.00 31.03 ? 357 TYR A CA  1 
ATOM   2570 C C   . TYR A 1 330 ? 22.847 -34.739 -28.325 1.00 30.59 ? 357 TYR A C   1 
ATOM   2571 O O   . TYR A 1 330 ? 23.528 -33.999 -29.045 1.00 32.34 ? 357 TYR A O   1 
ATOM   2572 C CB  . TYR A 1 330 ? 23.581 -36.713 -26.849 1.00 30.33 ? 357 TYR A CB  1 
ATOM   2573 C CG  . TYR A 1 330 ? 24.518 -37.262 -27.918 1.00 35.00 ? 357 TYR A CG  1 
ATOM   2574 C CD1 . TYR A 1 330 ? 24.076 -37.508 -29.211 1.00 36.64 ? 357 TYR A CD1 1 
ATOM   2575 C CD2 . TYR A 1 330 ? 25.854 -37.505 -27.646 1.00 36.81 ? 357 TYR A CD2 1 
ATOM   2576 C CE1 . TYR A 1 330 ? 24.920 -38.014 -30.187 1.00 38.20 ? 357 TYR A CE1 1 
ATOM   2577 C CE2 . TYR A 1 330 ? 26.715 -38.003 -28.613 1.00 37.07 ? 357 TYR A CE2 1 
ATOM   2578 C CZ  . TYR A 1 330 ? 26.248 -38.269 -29.886 1.00 41.04 ? 357 TYR A CZ  1 
ATOM   2579 O OH  . TYR A 1 330 ? 27.119 -38.731 -30.832 1.00 34.51 ? 357 TYR A OH  1 
ATOM   2580 N N   . THR A 1 331 ? 21.633 -35.178 -28.688 1.00 30.54 ? 358 THR A N   1 
ATOM   2581 C CA  . THR A 1 331 ? 21.048 -34.878 -29.988 1.00 29.09 ? 358 THR A CA  1 
ATOM   2582 C C   . THR A 1 331 ? 21.223 -33.398 -30.311 1.00 31.11 ? 358 THR A C   1 
ATOM   2583 O O   . THR A 1 331 ? 21.661 -33.054 -31.403 1.00 32.48 ? 358 THR A O   1 
ATOM   2584 C CB  . THR A 1 331 ? 19.572 -35.287 -30.006 1.00 29.65 ? 358 THR A CB  1 
ATOM   2585 O OG1 . THR A 1 331 ? 19.556 -36.662 -29.658 1.00 29.77 ? 358 THR A OG1 1 
ATOM   2586 C CG2 . THR A 1 331 ? 18.929 -35.186 -31.377 1.00 33.95 ? 358 THR A CG2 1 
ATOM   2587 N N   . CYS A 1 332 ? 20.934 -32.493 -29.367 1.00 31.69 ? 359 CYS A N   1 
ATOM   2588 C CA  . CYS A 1 332 ? 20.890 -31.089 -29.746 1.00 30.75 ? 359 CYS A CA  1 
ATOM   2589 C C   . CYS A 1 332 ? 22.291 -30.508 -29.936 1.00 31.07 ? 359 CYS A C   1 
ATOM   2590 O O   . CYS A 1 332 ? 22.456 -29.497 -30.620 1.00 29.91 ? 359 CYS A O   1 
ATOM   2591 C CB  . CYS A 1 332 ? 20.017 -30.282 -28.797 1.00 39.53 ? 359 CYS A CB  1 
ATOM   2592 S SG  . CYS A 1 332 ? 20.836 -29.912 -27.228 1.00 42.57 ? 359 CYS A SG  1 
ATOM   2593 N N   . GLN A 1 333 ? 23.315 -31.129 -29.340 1.00 30.25 ? 360 GLN A N   1 
ATOM   2594 C CA  . GLN A 1 333 ? 24.683 -30.687 -29.583 1.00 28.89 ? 360 GLN A CA  1 
ATOM   2595 C C   . GLN A 1 333 ? 25.148 -31.149 -30.966 1.00 28.77 ? 360 GLN A C   1 
ATOM   2596 O O   . GLN A 1 333 ? 25.872 -30.428 -31.646 1.00 31.49 ? 360 GLN A O   1 
ATOM   2597 C CB  . GLN A 1 333 ? 25.610 -31.219 -28.492 1.00 28.89 ? 360 GLN A CB  1 
ATOM   2598 C CG  . GLN A 1 333 ? 25.429 -30.527 -27.149 1.00 29.04 ? 360 GLN A CG  1 
ATOM   2599 C CD  . GLN A 1 333 ? 26.149 -31.265 -26.047 1.00 30.35 ? 360 GLN A CD  1 
ATOM   2600 O OE1 . GLN A 1 333 ? 25.706 -32.297 -25.532 1.00 33.65 ? 360 GLN A OE1 1 
ATOM   2601 N NE2 . GLN A 1 333 ? 27.303 -30.745 -25.694 1.00 29.46 ? 360 GLN A NE2 1 
ATOM   2602 N N   . ARG A 1 334 ? 24.763 -32.375 -31.335 1.00 31.39 ? 361 ARG A N   1 
ATOM   2603 C CA  . ARG A 1 334 ? 24.989 -32.927 -32.666 1.00 34.41 ? 361 ARG A CA  1 
ATOM   2604 C C   . ARG A 1 334 ? 24.440 -31.979 -33.731 1.00 36.32 ? 361 ARG A C   1 
ATOM   2605 O O   . ARG A 1 334 ? 25.175 -31.542 -34.630 1.00 39.82 ? 361 ARG A O   1 
ATOM   2606 C CB  . ARG A 1 334 ? 24.340 -34.313 -32.716 1.00 35.58 ? 361 ARG A CB  1 
ATOM   2607 C CG  . ARG A 1 334 ? 24.311 -34.950 -34.099 1.00 39.09 ? 361 ARG A CG  1 
ATOM   2608 C CD  . ARG A 1 334 ? 23.996 -36.426 -34.001 1.00 42.68 ? 361 ARG A CD  1 
ATOM   2609 N NE  . ARG A 1 334 ? 23.823 -37.071 -35.308 1.00 48.67 ? 361 ARG A NE  1 
ATOM   2610 C CZ  . ARG A 1 334 ? 24.759 -37.698 -36.022 1.00 56.07 ? 361 ARG A CZ  1 
ATOM   2611 N NH1 . ARG A 1 334 ? 26.054 -37.453 -35.837 1.00 54.96 ? 361 ARG A NH1 1 
ATOM   2612 N NH2 . ARG A 1 334 ? 24.381 -38.509 -36.997 1.00 55.04 ? 361 ARG A NH2 1 
ATOM   2613 N N   . GLU A 1 335 ? 23.164 -31.605 -33.580 1.00 36.15 ? 362 GLU A N   1 
ATOM   2614 C CA  . GLU A 1 335 ? 22.554 -30.644 -34.488 1.00 38.53 ? 362 GLU A CA  1 
ATOM   2615 C C   . GLU A 1 335 ? 23.423 -29.399 -34.622 1.00 36.10 ? 362 GLU A C   1 
ATOM   2616 O O   . GLU A 1 335 ? 23.672 -28.957 -35.735 1.00 39.85 ? 362 GLU A O   1 
ATOM   2617 C CB  . GLU A 1 335 ? 21.148 -30.244 -34.048 1.00 40.54 ? 362 GLU A CB  1 
ATOM   2618 C CG  . GLU A 1 335 ? 20.144 -31.379 -34.200 1.00 45.49 ? 362 GLU A CG  1 
ATOM   2619 C CD  . GLU A 1 335 ? 18.802 -31.095 -33.537 1.00 50.02 ? 362 GLU A CD  1 
ATOM   2620 O OE1 . GLU A 1 335 ? 18.545 -29.952 -33.083 1.00 47.77 ? 362 GLU A OE1 1 
ATOM   2621 O OE2 . GLU A 1 335 ? 18.026 -32.065 -33.451 1.00 52.06 ? 362 GLU A OE2 1 
ATOM   2622 N N   . PHE A 1 336 ? 23.852 -28.813 -33.492 1.00 31.69 ? 363 PHE A N   1 
ATOM   2623 C CA  . PHE A 1 336 ? 24.702 -27.636 -33.512 1.00 30.62 ? 363 PHE A CA  1 
ATOM   2624 C C   . PHE A 1 336 ? 25.970 -27.919 -34.334 1.00 33.56 ? 363 PHE A C   1 
ATOM   2625 O O   . PHE A 1 336 ? 26.352 -27.106 -35.178 1.00 36.24 ? 363 PHE A O   1 
ATOM   2626 C CB  . PHE A 1 336 ? 25.056 -27.223 -32.076 1.00 31.07 ? 363 PHE A CB  1 
ATOM   2627 C CG  . PHE A 1 336 ? 25.838 -25.928 -31.983 1.00 29.01 ? 363 PHE A CG  1 
ATOM   2628 C CD1 . PHE A 1 336 ? 27.209 -25.905 -32.180 1.00 33.93 ? 363 PHE A CD1 1 
ATOM   2629 C CD2 . PHE A 1 336 ? 25.193 -24.727 -31.713 1.00 31.26 ? 363 PHE A CD2 1 
ATOM   2630 C CE1 . PHE A 1 336 ? 27.906 -24.708 -32.146 1.00 33.80 ? 363 PHE A CE1 1 
ATOM   2631 C CE2 . PHE A 1 336 ? 25.895 -23.543 -31.653 1.00 32.47 ? 363 PHE A CE2 1 
ATOM   2632 C CZ  . PHE A 1 336 ? 27.260 -23.537 -31.863 1.00 32.22 ? 363 PHE A CZ  1 
ATOM   2633 N N   . ALA A 1 337 ? 26.615 -29.069 -34.080 1.00 33.15 ? 364 ALA A N   1 
ATOM   2634 C CA  . ALA A 1 337 ? 27.888 -29.416 -34.709 1.00 39.35 ? 364 ALA A CA  1 
ATOM   2635 C C   . ALA A 1 337 ? 27.727 -29.547 -36.224 1.00 40.41 ? 364 ALA A C   1 
ATOM   2636 O O   . ALA A 1 337 ? 28.346 -28.808 -36.989 1.00 39.20 ? 364 ALA A O   1 
ATOM   2637 C CB  . ALA A 1 337 ? 28.422 -30.719 -34.136 1.00 38.21 ? 364 ALA A CB  1 
ATOM   2638 N N   . LEU A 1 338 ? 26.863 -30.475 -36.655 1.00 45.31 ? 365 LEU A N   1 
ATOM   2639 C CA  . LEU A 1 338 ? 26.732 -30.722 -38.080 1.00 47.38 ? 365 LEU A CA  1 
ATOM   2640 C C   . LEU A 1 338 ? 26.191 -29.468 -38.762 1.00 45.28 ? 365 LEU A C   1 
ATOM   2641 O O   . LEU A 1 338 ? 26.411 -29.282 -39.953 1.00 50.99 ? 365 LEU A O   1 
ATOM   2642 C CB  . LEU A 1 338 ? 25.982 -31.994 -38.463 1.00 47.02 ? 365 LEU A CB  1 
ATOM   2643 C CG  . LEU A 1 338 ? 24.698 -32.336 -37.715 1.00 45.14 ? 365 LEU A CG  1 
ATOM   2644 C CD1 . LEU A 1 338 ? 23.556 -31.511 -38.264 1.00 51.41 ? 365 LEU A CD1 1 
ATOM   2645 C CD2 . LEU A 1 338 ? 24.428 -33.822 -37.800 1.00 43.29 ? 365 LEU A CD2 1 
ATOM   2646 N N   . LYS A 1 339 ? 25.609 -28.548 -37.985 1.00 49.59 ? 366 LYS A N   1 
ATOM   2647 C CA  . LYS A 1 339 ? 25.245 -27.238 -38.502 1.00 47.07 ? 366 LYS A CA  1 
ATOM   2648 C C   . LYS A 1 339 ? 26.451 -26.300 -38.547 1.00 45.40 ? 366 LYS A C   1 
ATOM   2649 O O   . LYS A 1 339 ? 26.544 -25.489 -39.458 1.00 45.78 ? 366 LYS A O   1 
ATOM   2650 C CB  . LYS A 1 339 ? 24.089 -26.638 -37.690 1.00 51.54 ? 366 LYS A CB  1 
ATOM   2651 C CG  . LYS A 1 339 ? 23.578 -25.281 -38.168 1.00 55.86 ? 366 LYS A CG  1 
ATOM   2652 C CD  . LYS A 1 339 ? 22.362 -24.782 -37.392 1.00 61.72 ? 366 LYS A CD  1 
ATOM   2653 C CE  . LYS A 1 339 ? 22.032 -23.321 -37.596 1.00 65.73 ? 366 LYS A CE  1 
ATOM   2654 N NZ  . LYS A 1 339 ? 21.421 -23.016 -38.896 1.00 66.52 ? 366 LYS A NZ  1 
ATOM   2655 N N   . HIS A 1 340 ? 27.368 -26.357 -37.570 1.00 43.56 ? 367 HIS A N   1 
ATOM   2656 C CA  . HIS A 1 340 ? 28.359 -25.289 -37.460 1.00 41.12 ? 367 HIS A CA  1 
ATOM   2657 C C   . HIS A 1 340 ? 29.811 -25.740 -37.615 1.00 36.07 ? 367 HIS A C   1 
ATOM   2658 O O   . HIS A 1 340 ? 30.678 -24.895 -37.769 1.00 34.20 ? 367 HIS A O   1 
ATOM   2659 C CB  . HIS A 1 340 ? 28.230 -24.532 -36.134 1.00 43.77 ? 367 HIS A CB  1 
ATOM   2660 C CG  . HIS A 1 340 ? 26.979 -23.734 -36.026 1.00 48.33 ? 367 HIS A CG  1 
ATOM   2661 N ND1 . HIS A 1 340 ? 26.746 -22.606 -36.784 1.00 51.75 ? 367 HIS A ND1 1 
ATOM   2662 C CD2 . HIS A 1 340 ? 25.890 -23.912 -35.276 1.00 48.80 ? 367 HIS A CD2 1 
ATOM   2663 C CE1 . HIS A 1 340 ? 25.553 -22.127 -36.490 1.00 48.26 ? 367 HIS A CE1 1 
ATOM   2664 N NE2 . HIS A 1 340 ? 25.028 -22.893 -35.560 1.00 46.00 ? 367 HIS A NE2 1 
ATOM   2665 N N   . LEU A 1 341 ? 30.103 -27.036 -37.528 1.00 41.28 ? 368 LEU A N   1 
ATOM   2666 C CA  . LEU A 1 341 ? 31.478 -27.496 -37.647 1.00 43.92 ? 368 LEU A CA  1 
ATOM   2667 C C   . LEU A 1 341 ? 31.471 -28.949 -38.106 1.00 44.28 ? 368 LEU A C   1 
ATOM   2668 O O   . LEU A 1 341 ? 31.998 -29.829 -37.429 1.00 39.59 ? 368 LEU A O   1 
ATOM   2669 C CB  . LEU A 1 341 ? 32.150 -27.297 -36.287 1.00 47.28 ? 368 LEU A CB  1 
ATOM   2670 C CG  . LEU A 1 341 ? 31.521 -28.039 -35.098 1.00 43.18 ? 368 LEU A CG  1 
ATOM   2671 C CD1 . LEU A 1 341 ? 32.488 -29.061 -34.500 1.00 40.66 ? 368 LEU A CD1 1 
ATOM   2672 C CD2 . LEU A 1 341 ? 31.001 -27.095 -34.017 1.00 42.57 ? 368 LEU A CD2 1 
ATOM   2673 N N   . PRO A 1 342 ? 30.849 -29.247 -39.271 1.00 42.92 ? 369 PRO A N   1 
ATOM   2674 C CA  . PRO A 1 342 ? 30.613 -30.632 -39.675 1.00 45.05 ? 369 PRO A CA  1 
ATOM   2675 C C   . PRO A 1 342 ? 31.874 -31.336 -40.172 1.00 40.84 ? 369 PRO A C   1 
ATOM   2676 O O   . PRO A 1 342 ? 31.897 -32.565 -40.216 1.00 37.44 ? 369 PRO A O   1 
ATOM   2677 C CB  . PRO A 1 342 ? 29.543 -30.507 -40.785 1.00 45.35 ? 369 PRO A CB  1 
ATOM   2678 C CG  . PRO A 1 342 ? 29.737 -29.132 -41.363 1.00 42.80 ? 369 PRO A CG  1 
ATOM   2679 C CD  . PRO A 1 342 ? 30.353 -28.279 -40.259 1.00 45.71 ? 369 PRO A CD  1 
ATOM   2680 N N   . ASN A 1 343 ? 32.888 -30.542 -40.552 1.00 42.70 ? 370 ASN A N   1 
ATOM   2681 C CA  . ASN A 1 343 ? 34.144 -31.068 -41.074 1.00 49.35 ? 370 ASN A CA  1 
ATOM   2682 C C   . ASN A 1 343 ? 35.214 -30.983 -39.993 1.00 51.06 ? 370 ASN A C   1 
ATOM   2683 O O   . ASN A 1 343 ? 36.398 -30.863 -40.307 1.00 50.66 ? 370 ASN A O   1 
ATOM   2684 C CB  . ASN A 1 343 ? 34.646 -30.331 -42.317 1.00 48.62 ? 370 ASN A CB  1 
ATOM   2685 C CG  . ASN A 1 343 ? 33.606 -30.276 -43.411 1.00 47.45 ? 370 ASN A CG  1 
ATOM   2686 O OD1 . ASN A 1 343 ? 32.974 -31.293 -43.718 1.00 44.50 ? 370 ASN A OD1 1 
ATOM   2687 N ND2 . ASN A 1 343 ? 33.380 -29.097 -43.972 1.00 51.49 ? 370 ASN A ND2 1 
ATOM   2688 N N   . ASP A 1 344 ? 34.776 -31.025 -38.727 1.00 50.65 ? 371 ASP A N   1 
ATOM   2689 C CA  . ASP A 1 344 ? 35.691 -31.066 -37.607 1.00 45.52 ? 371 ASP A CA  1 
ATOM   2690 C C   . ASP A 1 344 ? 36.100 -32.513 -37.392 1.00 40.81 ? 371 ASP A C   1 
ATOM   2691 O O   . ASP A 1 344 ? 35.250 -33.367 -37.134 1.00 45.52 ? 371 ASP A O   1 
ATOM   2692 C CB  . ASP A 1 344 ? 35.095 -30.520 -36.321 1.00 47.67 ? 371 ASP A CB  1 
ATOM   2693 C CG  . ASP A 1 344 ? 36.066 -30.566 -35.150 1.00 45.68 ? 371 ASP A CG  1 
ATOM   2694 O OD1 . ASP A 1 344 ? 37.058 -29.825 -35.205 1.00 46.38 ? 371 ASP A OD1 1 
ATOM   2695 O OD2 . ASP A 1 344 ? 35.866 -31.405 -34.253 1.00 48.03 ? 371 ASP A OD2 1 
ATOM   2696 N N   . PRO A 1 345 ? 37.416 -32.812 -37.462 1.00 40.53 ? 372 PRO A N   1 
ATOM   2697 C CA  . PRO A 1 345 ? 37.915 -34.186 -37.342 1.00 39.34 ? 372 PRO A CA  1 
ATOM   2698 C C   . PRO A 1 345 ? 37.451 -34.886 -36.073 1.00 35.83 ? 372 PRO A C   1 
ATOM   2699 O O   . PRO A 1 345 ? 37.091 -36.068 -36.106 1.00 40.64 ? 372 PRO A O   1 
ATOM   2700 C CB  . PRO A 1 345 ? 39.460 -34.067 -37.382 1.00 38.43 ? 372 PRO A CB  1 
ATOM   2701 C CG  . PRO A 1 345 ? 39.740 -32.650 -37.866 1.00 39.39 ? 372 PRO A CG  1 
ATOM   2702 C CD  . PRO A 1 345 ? 38.486 -31.827 -37.655 1.00 37.57 ? 372 PRO A CD  1 
ATOM   2703 N N   . MET A 1 346 ? 37.505 -34.163 -34.943 1.00 40.23 ? 373 MET A N   1 
ATOM   2704 C CA  . MET A 1 346 ? 37.111 -34.726 -33.655 1.00 41.49 ? 373 MET A CA  1 
ATOM   2705 C C   . MET A 1 346 ? 35.607 -35.005 -33.656 1.00 35.47 ? 373 MET A C   1 
ATOM   2706 O O   . MET A 1 346 ? 35.173 -36.058 -33.204 1.00 36.69 ? 373 MET A O   1 
ATOM   2707 C CB  . MET A 1 346 ? 37.498 -33.788 -32.505 1.00 44.31 ? 373 MET A CB  1 
ATOM   2708 C CG  . MET A 1 346 ? 38.992 -33.721 -32.261 1.00 53.22 ? 373 MET A CG  1 
ATOM   2709 S SD  . MET A 1 346 ? 39.617 -35.291 -31.620 1.00 64.14 ? 373 MET A SD  1 
ATOM   2710 C CE  . MET A 1 346 ? 39.062 -35.357 -29.911 1.00 60.07 ? 373 MET A CE  1 
ATOM   2711 N N   . PHE A 1 347 ? 34.828 -34.056 -34.183 1.00 38.79 ? 374 PHE A N   1 
ATOM   2712 C CA  . PHE A 1 347 ? 33.385 -34.228 -34.308 1.00 40.99 ? 374 PHE A CA  1 
ATOM   2713 C C   . PHE A 1 347 ? 33.085 -35.453 -35.166 1.00 37.32 ? 374 PHE A C   1 
ATOM   2714 O O   . PHE A 1 347 ? 32.212 -36.248 -34.812 1.00 36.87 ? 374 PHE A O   1 
ATOM   2715 C CB  . PHE A 1 347 ? 32.618 -33.040 -34.903 1.00 39.26 ? 374 PHE A CB  1 
ATOM   2716 C CG  . PHE A 1 347 ? 31.187 -33.427 -35.258 1.00 47.02 ? 374 PHE A CG  1 
ATOM   2717 C CD1 . PHE A 1 347 ? 30.360 -34.047 -34.322 1.00 48.54 ? 374 PHE A CD1 1 
ATOM   2718 C CD2 . PHE A 1 347 ? 30.701 -33.268 -36.554 1.00 53.01 ? 374 PHE A CD2 1 
ATOM   2719 C CE1 . PHE A 1 347 ? 29.066 -34.427 -34.650 1.00 49.79 ? 374 PHE A CE1 1 
ATOM   2720 C CE2 . PHE A 1 347 ? 29.409 -33.661 -36.883 1.00 51.80 ? 374 PHE A CE2 1 
ATOM   2721 C CZ  . PHE A 1 347 ? 28.595 -34.238 -35.932 1.00 54.76 ? 374 PHE A CZ  1 
ATOM   2722 N N   . LYS A 1 348 ? 33.809 -35.614 -36.285 1.00 43.46 ? 375 LYS A N   1 
ATOM   2723 C CA  . LYS A 1 348 ? 33.587 -36.779 -37.143 1.00 41.16 ? 375 LYS A CA  1 
ATOM   2724 C C   . LYS A 1 348 ? 33.768 -38.076 -36.349 1.00 36.81 ? 375 LYS A C   1 
ATOM   2725 O O   . LYS A 1 348 ? 32.967 -39.008 -36.464 1.00 34.18 ? 375 LYS A O   1 
ATOM   2726 C CB  . LYS A 1 348 ? 34.463 -36.720 -38.399 1.00 42.95 ? 375 LYS A CB  1 
ATOM   2727 C CG  . LYS A 1 348 ? 33.891 -35.833 -39.489 1.00 47.82 ? 375 LYS A CG  1 
ATOM   2728 C CD  . LYS A 1 348 ? 34.823 -35.549 -40.659 1.00 52.73 ? 375 LYS A CD  1 
ATOM   2729 C CE  . LYS A 1 348 ? 35.722 -34.380 -40.391 1.00 57.32 ? 375 LYS A CE  1 
ATOM   2730 N NZ  . LYS A 1 348 ? 36.910 -34.367 -41.255 1.00 56.39 ? 375 LYS A NZ  1 
ATOM   2731 N N   . LEU A 1 349 ? 34.810 -38.129 -35.505 1.00 36.41 ? 376 LEU A N   1 
ATOM   2732 C CA  . LEU A 1 349 ? 35.007 -39.286 -34.651 1.00 36.74 ? 376 LEU A CA  1 
ATOM   2733 C C   . LEU A 1 349 ? 33.795 -39.443 -33.732 1.00 37.78 ? 376 LEU A C   1 
ATOM   2734 O O   . LEU A 1 349 ? 33.306 -40.557 -33.517 1.00 38.29 ? 376 LEU A O   1 
ATOM   2735 C CB  . LEU A 1 349 ? 36.311 -39.142 -33.858 1.00 36.49 ? 376 LEU A CB  1 
ATOM   2736 C CG  . LEU A 1 349 ? 36.558 -40.170 -32.750 1.00 37.89 ? 376 LEU A CG  1 
ATOM   2737 C CD1 . LEU A 1 349 ? 36.390 -41.643 -33.144 1.00 38.97 ? 376 LEU A CD1 1 
ATOM   2738 C CD2 . LEU A 1 349 ? 37.969 -39.959 -32.215 1.00 40.67 ? 376 LEU A CD2 1 
ATOM   2739 N N   . VAL A 1 350 ? 33.345 -38.321 -33.147 1.00 34.57 ? 377 VAL A N   1 
ATOM   2740 C CA  . VAL A 1 350 ? 32.176 -38.357 -32.278 1.00 37.48 ? 377 VAL A CA  1 
ATOM   2741 C C   . VAL A 1 350 ? 30.994 -38.921 -33.086 1.00 33.70 ? 377 VAL A C   1 
ATOM   2742 O O   . VAL A 1 350 ? 30.345 -39.860 -32.637 1.00 33.39 ? 377 VAL A O   1 
ATOM   2743 C CB  . VAL A 1 350 ? 31.893 -36.980 -31.632 1.00 34.23 ? 377 VAL A CB  1 
ATOM   2744 C CG1 . VAL A 1 350 ? 30.498 -36.880 -31.017 1.00 36.65 ? 377 VAL A CG1 1 
ATOM   2745 C CG2 . VAL A 1 350 ? 32.928 -36.655 -30.570 1.00 37.34 ? 377 VAL A CG2 1 
ATOM   2746 N N   . ALA A 1 351 ? 30.771 -38.396 -34.298 1.00 35.99 ? 378 ALA A N   1 
ATOM   2747 C CA  . ALA A 1 351 ? 29.728 -38.914 -35.195 1.00 40.09 ? 378 ALA A CA  1 
ATOM   2748 C C   . ALA A 1 351 ? 29.904 -40.407 -35.470 1.00 39.88 ? 378 ALA A C   1 
ATOM   2749 O O   . ALA A 1 351 ? 28.956 -41.192 -35.341 1.00 42.46 ? 378 ALA A O   1 
ATOM   2750 C CB  . ALA A 1 351 ? 29.712 -38.127 -36.481 1.00 38.86 ? 378 ALA A CB  1 
ATOM   2751 N N   . GLN A 1 352 ? 31.138 -40.809 -35.795 1.00 40.55 ? 379 GLN A N   1 
ATOM   2752 C CA  . GLN A 1 352 ? 31.419 -42.203 -36.103 1.00 39.64 ? 379 GLN A CA  1 
ATOM   2753 C C   . GLN A 1 352 ? 31.011 -43.116 -34.961 1.00 39.61 ? 379 GLN A C   1 
ATOM   2754 O O   . GLN A 1 352 ? 30.364 -44.141 -35.166 1.00 43.60 ? 379 GLN A O   1 
ATOM   2755 C CB  . GLN A 1 352 ? 32.909 -42.474 -36.266 1.00 43.71 ? 379 GLN A CB  1 
ATOM   2756 C CG  . GLN A 1 352 ? 33.425 -42.362 -37.690 1.00 45.11 ? 379 GLN A CG  1 
ATOM   2757 C CD  . GLN A 1 352 ? 34.709 -43.139 -37.866 1.00 50.14 ? 379 GLN A CD  1 
ATOM   2758 O OE1 . GLN A 1 352 ? 35.800 -42.563 -37.941 1.00 42.44 ? 379 GLN A OE1 1 
ATOM   2759 N NE2 . GLN A 1 352 ? 34.585 -44.462 -37.869 1.00 54.84 ? 379 GLN A NE2 1 
ATOM   2760 N N   . LEU A 1 353 ? 31.452 -42.756 -33.750 1.00 41.20 ? 380 LEU A N   1 
ATOM   2761 C CA  . LEU A 1 353 ? 31.163 -43.542 -32.561 1.00 36.74 ? 380 LEU A CA  1 
ATOM   2762 C C   . LEU A 1 353 ? 29.653 -43.672 -32.339 1.00 36.09 ? 380 LEU A C   1 
ATOM   2763 O O   . LEU A 1 353 ? 29.171 -44.695 -31.839 1.00 37.65 ? 380 LEU A O   1 
ATOM   2764 C CB  . LEU A 1 353 ? 31.863 -42.862 -31.382 1.00 37.86 ? 380 LEU A CB  1 
ATOM   2765 C CG  . LEU A 1 353 ? 33.394 -42.934 -31.385 1.00 36.68 ? 380 LEU A CG  1 
ATOM   2766 C CD1 . LEU A 1 353 ? 33.975 -41.903 -30.451 1.00 40.37 ? 380 LEU A CD1 1 
ATOM   2767 C CD2 . LEU A 1 353 ? 33.838 -44.334 -30.979 1.00 37.90 ? 380 LEU A CD2 1 
ATOM   2768 N N   . TYR A 1 354 ? 28.897 -42.633 -32.705 1.00 43.18 ? 381 TYR A N   1 
ATOM   2769 C CA  . TYR A 1 354 ? 27.448 -42.679 -32.537 1.00 49.25 ? 381 TYR A CA  1 
ATOM   2770 C C   . TYR A 1 354 ? 26.872 -43.948 -33.187 1.00 48.82 ? 381 TYR A C   1 
ATOM   2771 O O   . TYR A 1 354 ? 26.081 -44.656 -32.564 1.00 42.97 ? 381 TYR A O   1 
ATOM   2772 C CB  . TYR A 1 354 ? 26.835 -41.372 -33.059 1.00 50.50 ? 381 TYR A CB  1 
ATOM   2773 C CG  . TYR A 1 354 ? 25.337 -41.227 -32.800 1.00 47.06 ? 381 TYR A CG  1 
ATOM   2774 C CD1 . TYR A 1 354 ? 24.687 -42.022 -31.859 1.00 41.83 ? 381 TYR A CD1 1 
ATOM   2775 C CD2 . TYR A 1 354 ? 24.577 -40.294 -33.495 1.00 46.68 ? 381 TYR A CD2 1 
ATOM   2776 C CE1 . TYR A 1 354 ? 23.331 -41.908 -31.625 1.00 41.18 ? 381 TYR A CE1 1 
ATOM   2777 C CE2 . TYR A 1 354 ? 23.218 -40.152 -33.251 1.00 43.95 ? 381 TYR A CE2 1 
ATOM   2778 C CZ  . TYR A 1 354 ? 22.599 -40.958 -32.310 1.00 42.55 ? 381 TYR A CZ  1 
ATOM   2779 O OH  . TYR A 1 354 ? 21.264 -40.870 -32.038 1.00 49.98 ? 381 TYR A OH  1 
ATOM   2780 N N   . LYS A 1 355 ? 27.332 -44.273 -34.404 1.00 54.30 ? 382 LYS A N   1 
ATOM   2781 C CA  . LYS A 1 355 ? 26.804 -45.390 -35.182 1.00 62.40 ? 382 LYS A CA  1 
ATOM   2782 C C   . LYS A 1 355 ? 27.238 -46.736 -34.603 1.00 62.96 ? 382 LYS A C   1 
ATOM   2783 O O   . LYS A 1 355 ? 26.438 -47.677 -34.482 1.00 48.26 ? 382 LYS A O   1 
ATOM   2784 C CB  . LYS A 1 355 ? 27.339 -45.331 -36.616 1.00 63.35 ? 382 LYS A CB  1 
ATOM   2785 C CG  . LYS A 1 355 ? 27.079 -44.027 -37.357 1.00 67.23 ? 382 LYS A CG  1 
ATOM   2786 C CD  . LYS A 1 355 ? 27.954 -43.833 -38.589 1.00 74.22 ? 382 LYS A CD  1 
ATOM   2787 C CE  . LYS A 1 355 ? 27.807 -44.929 -39.606 1.00 76.78 ? 382 LYS A CE  1 
ATOM   2788 N NZ  . LYS A 1 355 ? 28.932 -44.956 -40.547 1.00 77.77 ? 382 LYS A NZ  1 
ATOM   2789 N N   . ILE A 1 356 ? 28.528 -46.803 -34.249 1.00 60.59 ? 383 ILE A N   1 
ATOM   2790 C CA  . ILE A 1 356 ? 29.191 -48.059 -33.956 1.00 52.37 ? 383 ILE A CA  1 
ATOM   2791 C C   . ILE A 1 356 ? 28.953 -48.455 -32.505 1.00 52.30 ? 383 ILE A C   1 
ATOM   2792 O O   . ILE A 1 356 ? 28.620 -49.609 -32.203 1.00 50.36 ? 383 ILE A O   1 
ATOM   2793 C CB  . ILE A 1 356 ? 30.688 -47.925 -34.273 1.00 54.71 ? 383 ILE A CB  1 
ATOM   2794 C CG1 . ILE A 1 356 ? 30.911 -47.729 -35.754 1.00 56.08 ? 383 ILE A CG1 1 
ATOM   2795 C CG2 . ILE A 1 356 ? 31.478 -49.115 -33.740 1.00 55.27 ? 383 ILE A CG2 1 
ATOM   2796 C CD1 . ILE A 1 356 ? 32.105 -46.856 -36.071 1.00 59.38 ? 383 ILE A CD1 1 
ATOM   2797 N N   . VAL A 1 357 ? 29.150 -47.500 -31.592 1.00 45.19 ? 384 VAL A N   1 
ATOM   2798 C CA  . VAL A 1 357 ? 29.229 -47.873 -30.193 1.00 40.06 ? 384 VAL A CA  1 
ATOM   2799 C C   . VAL A 1 357 ? 27.923 -48.531 -29.748 1.00 45.55 ? 384 VAL A C   1 
ATOM   2800 O O   . VAL A 1 357 ? 27.967 -49.503 -28.990 1.00 47.56 ? 384 VAL A O   1 
ATOM   2801 C CB  . VAL A 1 357 ? 29.611 -46.671 -29.308 1.00 37.23 ? 384 VAL A CB  1 
ATOM   2802 C CG1 . VAL A 1 357 ? 29.475 -46.990 -27.827 1.00 33.08 ? 384 VAL A CG1 1 
ATOM   2803 C CG2 . VAL A 1 357 ? 31.011 -46.181 -29.639 1.00 38.50 ? 384 VAL A CG2 1 
ATOM   2804 N N   . PRO A 1 358 ? 26.728 -47.998 -30.121 1.00 50.51 ? 385 PRO A N   1 
ATOM   2805 C CA  . PRO A 1 358 ? 25.450 -48.572 -29.670 1.00 53.59 ? 385 PRO A CA  1 
ATOM   2806 C C   . PRO A 1 358 ? 25.290 -50.086 -29.819 1.00 48.51 ? 385 PRO A C   1 
ATOM   2807 O O   . PRO A 1 358 ? 24.911 -50.750 -28.857 1.00 45.43 ? 385 PRO A O   1 
ATOM   2808 C CB  . PRO A 1 358 ? 24.433 -47.801 -30.532 1.00 53.38 ? 385 PRO A CB  1 
ATOM   2809 C CG  . PRO A 1 358 ? 25.075 -46.444 -30.694 1.00 53.80 ? 385 PRO A CG  1 
ATOM   2810 C CD  . PRO A 1 358 ? 26.538 -46.784 -30.939 1.00 48.85 ? 385 PRO A CD  1 
ATOM   2811 N N   . ASN A 1 359 ? 25.591 -50.602 -31.020 1.00 60.23 ? 386 ASN A N   1 
ATOM   2812 C CA  . ASN A 1 359 ? 25.507 -52.028 -31.326 1.00 68.26 ? 386 ASN A CA  1 
ATOM   2813 C C   . ASN A 1 359 ? 26.380 -52.830 -30.361 1.00 69.01 ? 386 ASN A C   1 
ATOM   2814 O O   . ASN A 1 359 ? 25.921 -53.776 -29.706 1.00 63.13 ? 386 ASN A O   1 
ATOM   2815 C CB  . ASN A 1 359 ? 25.904 -52.304 -32.774 1.00 72.76 ? 386 ASN A CB  1 
ATOM   2816 C CG  . ASN A 1 359 ? 25.461 -53.670 -33.255 1.00 79.38 ? 386 ASN A CG  1 
ATOM   2817 O OD1 . ASN A 1 359 ? 24.772 -54.406 -32.534 1.00 77.72 ? 386 ASN A OD1 1 
ATOM   2818 N ND2 . ASN A 1 359 ? 25.821 -54.017 -34.482 1.00 73.27 ? 386 ASN A ND2 1 
ATOM   2819 N N   . VAL A 1 360 ? 27.653 -52.433 -30.279 1.00 58.48 ? 387 VAL A N   1 
ATOM   2820 C CA  . VAL A 1 360 ? 28.491 -52.894 -29.194 1.00 55.03 ? 387 VAL A CA  1 
ATOM   2821 C C   . VAL A 1 360 ? 27.909 -52.260 -27.934 1.00 59.36 ? 387 VAL A C   1 
ATOM   2822 O O   . VAL A 1 360 ? 27.485 -51.106 -27.978 1.00 54.06 ? 387 VAL A O   1 
ATOM   2823 C CB  . VAL A 1 360 ? 29.986 -52.534 -29.347 1.00 53.94 ? 387 VAL A CB  1 
ATOM   2824 C CG1 . VAL A 1 360 ? 30.847 -53.472 -28.506 1.00 52.64 ? 387 VAL A CG1 1 
ATOM   2825 C CG2 . VAL A 1 360 ? 30.467 -52.511 -30.799 1.00 46.95 ? 387 VAL A CG2 1 
ATOM   2826 N N   . LEU A 1 361 ? 27.924 -53.007 -26.823 1.00 62.07 ? 388 LEU A N   1 
ATOM   2827 C CA  . LEU A 1 361 ? 27.290 -52.608 -25.571 1.00 65.32 ? 388 LEU A CA  1 
ATOM   2828 C C   . LEU A 1 361 ? 25.995 -53.403 -25.469 1.00 63.84 ? 388 LEU A C   1 
ATOM   2829 O O   . LEU A 1 361 ? 25.667 -53.901 -24.391 1.00 68.18 ? 388 LEU A O   1 
ATOM   2830 C CB  . LEU A 1 361 ? 27.026 -51.106 -25.368 1.00 70.43 ? 388 LEU A CB  1 
ATOM   2831 C CG  . LEU A 1 361 ? 28.104 -50.269 -24.657 1.00 70.30 ? 388 LEU A CG  1 
ATOM   2832 C CD1 . LEU A 1 361 ? 29.513 -50.417 -25.201 1.00 70.01 ? 388 LEU A CD1 1 
ATOM   2833 C CD2 . LEU A 1 361 ? 27.711 -48.795 -24.690 1.00 67.96 ? 388 LEU A CD2 1 
ATOM   2834 N N   . LEU A 1 362 ? 25.274 -53.478 -26.601 1.00 66.08 ? 389 LEU A N   1 
ATOM   2835 C CA  . LEU A 1 362 ? 24.166 -54.409 -26.799 1.00 73.58 ? 389 LEU A CA  1 
ATOM   2836 C C   . LEU A 1 362 ? 24.648 -55.853 -26.639 1.00 73.43 ? 389 LEU A C   1 
ATOM   2837 O O   . LEU A 1 362 ? 24.284 -56.520 -25.667 1.00 63.62 ? 389 LEU A O   1 
ATOM   2838 C CB  . LEU A 1 362 ? 23.519 -54.167 -28.169 1.00 72.77 ? 389 LEU A CB  1 
ATOM   2839 C CG  . LEU A 1 362 ? 22.129 -53.512 -28.193 1.00 78.88 ? 389 LEU A CG  1 
ATOM   2840 C CD1 . LEU A 1 362 ? 21.735 -52.767 -26.923 1.00 77.56 ? 389 LEU A CD1 1 
ATOM   2841 C CD2 . LEU A 1 362 ? 22.030 -52.563 -29.391 1.00 77.08 ? 389 LEU A CD2 1 
ATOM   2842 N N   . GLU A 1 363 ? 25.476 -56.324 -27.582 1.00 68.82 ? 390 GLU A N   1 
ATOM   2843 C CA  . GLU A 1 363 ? 26.014 -57.673 -27.505 1.00 66.90 ? 390 GLU A CA  1 
ATOM   2844 C C   . GLU A 1 363 ? 26.669 -57.896 -26.144 1.00 66.09 ? 390 GLU A C   1 
ATOM   2845 O O   . GLU A 1 363 ? 26.325 -58.855 -25.459 1.00 65.84 ? 390 GLU A O   1 
ATOM   2846 C CB  . GLU A 1 363 ? 27.015 -58.093 -28.581 1.00 70.04 ? 390 GLU A CB  1 
ATOM   2847 C CG  . GLU A 1 363 ? 27.547 -56.976 -29.472 1.00 74.04 ? 390 GLU A CG  1 
ATOM   2848 C CD  . GLU A 1 363 ? 26.751 -56.875 -30.756 1.00 70.18 ? 390 GLU A CD  1 
ATOM   2849 O OE1 . GLU A 1 363 ? 25.633 -56.325 -30.713 1.00 73.06 ? 390 GLU A OE1 1 
ATOM   2850 O OE2 . GLU A 1 363 ? 27.243 -57.403 -31.775 1.00 55.32 ? 390 GLU A OE2 1 
ATOM   2851 N N   . GLN A 1 364 ? 27.608 -57.024 -25.759 1.00 60.78 ? 391 GLN A N   1 
ATOM   2852 C CA  . GLN A 1 364 ? 28.200 -57.105 -24.430 1.00 65.57 ? 391 GLN A CA  1 
ATOM   2853 C C   . GLN A 1 364 ? 27.115 -57.429 -23.395 1.00 65.30 ? 391 GLN A C   1 
ATOM   2854 O O   . GLN A 1 364 ? 27.354 -58.164 -22.436 1.00 48.63 ? 391 GLN A O   1 
ATOM   2855 C CB  . GLN A 1 364 ? 29.012 -55.840 -24.120 1.00 67.73 ? 391 GLN A CB  1 
ATOM   2856 C CG  . GLN A 1 364 ? 28.839 -55.318 -22.696 1.00 70.81 ? 391 GLN A CG  1 
ATOM   2857 C CD  . GLN A 1 364 ? 30.138 -54.957 -22.013 1.00 68.04 ? 391 GLN A CD  1 
ATOM   2858 O OE1 . GLN A 1 364 ? 31.129 -55.686 -22.111 1.00 76.51 ? 391 GLN A OE1 1 
ATOM   2859 N NE2 . GLN A 1 364 ? 30.146 -53.849 -21.285 1.00 62.08 ? 391 GLN A NE2 1 
ATOM   2860 N N   . GLY A 1 365 ? 25.911 -56.880 -23.607 1.00 74.05 ? 392 GLY A N   1 
ATOM   2861 C CA  . GLY A 1 365 ? 24.795 -57.064 -22.696 1.00 72.40 ? 392 GLY A CA  1 
ATOM   2862 C C   . GLY A 1 365 ? 24.812 -55.939 -21.675 1.00 75.51 ? 392 GLY A C   1 
ATOM   2863 O O   . GLY A 1 365 ? 24.388 -54.827 -21.988 1.00 75.48 ? 392 GLY A O   1 
ATOM   2864 N N   . LYS A 1 366 ? 25.422 -56.208 -20.525 1.00 76.49 ? 393 LYS A N   1 
ATOM   2865 C CA  . LYS A 1 366 ? 25.553 -55.186 -19.458 1.00 82.36 ? 393 LYS A CA  1 
ATOM   2866 C C   . LYS A 1 366 ? 25.579 -53.783 -20.058 1.00 83.30 ? 393 LYS A C   1 
ATOM   2867 O O   . LYS A 1 366 ? 26.608 -53.461 -20.694 1.00 82.50 ? 393 LYS A O   1 
ATOM   2868 C CB  . LYS A 1 366 ? 26.881 -55.408 -18.737 1.00 83.16 ? 393 LYS A CB  1 
ATOM   2869 N N   . ALA A 1 367 ? 24.524 -52.999 -19.836 1.00 80.57 ? 394 ALA A N   1 
ATOM   2870 C CA  . ALA A 1 367 ? 24.525 -51.588 -20.294 1.00 84.32 ? 394 ALA A CA  1 
ATOM   2871 C C   . ALA A 1 367 ? 23.216 -50.895 -19.932 1.00 81.72 ? 394 ALA A C   1 
ATOM   2872 O O   . ALA A 1 367 ? 23.306 -49.701 -19.605 1.00 88.69 ? 394 ALA A O   1 
ATOM   2873 C CB  . ALA A 1 367 ? 24.768 -51.494 -21.783 1.00 80.11 ? 394 ALA A CB  1 
ATOM   2874 N N   . LYS A 1 368 ? 22.077 -51.580 -20.005 1.00 77.25 ? 395 LYS A N   1 
ATOM   2875 C CA  . LYS A 1 368 ? 20.782 -50.947 -19.784 1.00 73.10 ? 395 LYS A CA  1 
ATOM   2876 C C   . LYS A 1 368 ? 20.582 -49.853 -20.830 1.00 69.85 ? 395 LYS A C   1 
ATOM   2877 O O   . LYS A 1 368 ? 19.666 -49.938 -21.642 1.00 72.57 ? 395 LYS A O   1 
ATOM   2878 C CB  . LYS A 1 368 ? 20.526 -50.354 -18.390 1.00 74.82 ? 395 LYS A CB  1 
ATOM   2879 C CG  . LYS A 1 368 ? 20.000 -51.287 -17.305 1.00 76.81 ? 395 LYS A CG  1 
ATOM   2880 C CD  . LYS A 1 368 ? 21.068 -52.024 -16.506 1.00 79.17 ? 395 LYS A CD  1 
ATOM   2881 C CE  . LYS A 1 368 ? 20.579 -52.472 -15.163 1.00 79.76 ? 395 LYS A CE  1 
ATOM   2882 N NZ  . LYS A 1 368 ? 21.700 -52.899 -14.319 1.00 79.50 ? 395 LYS A NZ  1 
ATOM   2883 N N   . ASN A 1 369 ? 21.426 -48.815 -20.787 1.00 67.58 ? 396 ASN A N   1 
ATOM   2884 C CA  . ASN A 1 369 ? 21.401 -47.760 -21.785 1.00 65.71 ? 396 ASN A CA  1 
ATOM   2885 C C   . ASN A 1 369 ? 22.657 -47.864 -22.643 1.00 65.63 ? 396 ASN A C   1 
ATOM   2886 O O   . ASN A 1 369 ? 23.732 -47.463 -22.210 1.00 65.75 ? 396 ASN A O   1 
ATOM   2887 C CB  . ASN A 1 369 ? 21.239 -46.389 -21.136 1.00 64.07 ? 396 ASN A CB  1 
ATOM   2888 C CG  . ASN A 1 369 ? 21.214 -45.257 -22.139 1.00 61.57 ? 396 ASN A CG  1 
ATOM   2889 O OD1 . ASN A 1 369 ? 20.764 -45.413 -23.281 1.00 53.55 ? 396 ASN A OD1 1 
ATOM   2890 N ND2 . ASN A 1 369 ? 21.723 -44.102 -21.741 1.00 70.63 ? 396 ASN A ND2 1 
ATOM   2891 N N   . PRO A 1 370 ? 22.557 -48.391 -23.884 1.00 65.43 ? 397 PRO A N   1 
ATOM   2892 C CA  . PRO A 1 370 ? 23.701 -48.467 -24.796 1.00 62.84 ? 397 PRO A CA  1 
ATOM   2893 C C   . PRO A 1 370 ? 23.922 -47.192 -25.602 1.00 54.29 ? 397 PRO A C   1 
ATOM   2894 O O   . PRO A 1 370 ? 24.802 -47.128 -26.452 1.00 52.75 ? 397 PRO A O   1 
ATOM   2895 C CB  . PRO A 1 370 ? 23.267 -49.631 -25.699 1.00 66.45 ? 397 PRO A CB  1 
ATOM   2896 C CG  . PRO A 1 370 ? 21.783 -49.393 -25.866 1.00 68.34 ? 397 PRO A CG  1 
ATOM   2897 C CD  . PRO A 1 370 ? 21.328 -48.946 -24.479 1.00 70.63 ? 397 PRO A CD  1 
ATOM   2898 N N   . TRP A 1 371 ? 23.096 -46.182 -25.347 1.00 50.34 ? 398 TRP A N   1 
ATOM   2899 C CA  . TRP A 1 371 ? 23.086 -44.992 -26.174 1.00 45.40 ? 398 TRP A CA  1 
ATOM   2900 C C   . TRP A 1 371 ? 23.891 -43.880 -25.490 1.00 40.43 ? 398 TRP A C   1 
ATOM   2901 O O   . TRP A 1 371 ? 24.269 -44.006 -24.331 1.00 39.21 ? 398 TRP A O   1 
ATOM   2902 C CB  . TRP A 1 371 ? 21.622 -44.605 -26.426 1.00 45.25 ? 398 TRP A CB  1 
ATOM   2903 C CG  . TRP A 1 371 ? 20.857 -45.627 -27.229 1.00 39.85 ? 398 TRP A CG  1 
ATOM   2904 C CD1 . TRP A 1 371 ? 20.006 -46.581 -26.756 1.00 38.93 ? 398 TRP A CD1 1 
ATOM   2905 C CD2 . TRP A 1 371 ? 20.899 -45.793 -28.661 1.00 37.24 ? 398 TRP A CD2 1 
ATOM   2906 N NE1 . TRP A 1 371 ? 19.512 -47.329 -27.793 1.00 37.72 ? 398 TRP A NE1 1 
ATOM   2907 C CE2 . TRP A 1 371 ? 20.042 -46.870 -28.971 1.00 41.05 ? 398 TRP A CE2 1 
ATOM   2908 C CE3 . TRP A 1 371 ? 21.573 -45.144 -29.707 1.00 39.84 ? 398 TRP A CE3 1 
ATOM   2909 C CZ2 . TRP A 1 371 ? 19.848 -47.304 -30.281 1.00 41.41 ? 398 TRP A CZ2 1 
ATOM   2910 C CZ3 . TRP A 1 371 ? 21.374 -45.571 -31.004 1.00 44.60 ? 398 TRP A CZ3 1 
ATOM   2911 C CH2 . TRP A 1 371 ? 20.519 -46.639 -31.285 1.00 42.33 ? 398 TRP A CH2 1 
ATOM   2912 N N   . PRO A 1 372 ? 24.243 -42.798 -26.206 1.00 35.98 ? 399 PRO A N   1 
ATOM   2913 C CA  . PRO A 1 372 ? 25.031 -41.709 -25.626 1.00 38.13 ? 399 PRO A CA  1 
ATOM   2914 C C   . PRO A 1 372 ? 24.291 -40.764 -24.679 1.00 41.47 ? 399 PRO A C   1 
ATOM   2915 O O   . PRO A 1 372 ? 23.103 -40.493 -24.857 1.00 47.16 ? 399 PRO A O   1 
ATOM   2916 C CB  . PRO A 1 372 ? 25.576 -40.956 -26.857 1.00 33.05 ? 399 PRO A CB  1 
ATOM   2917 C CG  . PRO A 1 372 ? 24.651 -41.315 -27.995 1.00 33.59 ? 399 PRO A CG  1 
ATOM   2918 C CD  . PRO A 1 372 ? 24.020 -42.642 -27.645 1.00 33.77 ? 399 PRO A CD  1 
ATOM   2919 N N   . ASN A 1 373 ? 25.029 -40.268 -23.674 1.00 38.39 ? 400 ASN A N   1 
ATOM   2920 C CA  . ASN A 1 373 ? 24.583 -39.181 -22.811 1.00 33.59 ? 400 ASN A CA  1 
ATOM   2921 C C   . ASN A 1 373 ? 25.209 -37.874 -23.298 1.00 29.49 ? 400 ASN A C   1 
ATOM   2922 O O   . ASN A 1 373 ? 26.064 -37.881 -24.174 1.00 29.19 ? 400 ASN A O   1 
ATOM   2923 C CB  . ASN A 1 373 ? 24.955 -39.464 -21.362 1.00 35.68 ? 400 ASN A CB  1 
ATOM   2924 C CG  . ASN A 1 373 ? 26.450 -39.643 -21.204 1.00 33.71 ? 400 ASN A CG  1 
ATOM   2925 O OD1 . ASN A 1 373 ? 27.224 -38.768 -21.614 1.00 30.88 ? 400 ASN A OD1 1 
ATOM   2926 N ND2 . ASN A 1 373 ? 26.867 -40.779 -20.665 1.00 34.20 ? 400 ASN A ND2 1 
ATOM   2927 N N   . VAL A 1 374 ? 24.805 -36.752 -22.692 1.00 30.46 ? 401 VAL A N   1 
ATOM   2928 C CA  . VAL A 1 374 ? 25.289 -35.425 -23.047 1.00 28.15 ? 401 VAL A CA  1 
ATOM   2929 C C   . VAL A 1 374 ? 26.819 -35.345 -23.080 1.00 27.81 ? 401 VAL A C   1 
ATOM   2930 O O   . VAL A 1 374 ? 27.366 -34.586 -23.870 1.00 31.92 ? 401 VAL A O   1 
ATOM   2931 C CB  . VAL A 1 374 ? 24.712 -34.384 -22.060 1.00 31.06 ? 401 VAL A CB  1 
ATOM   2932 C CG1 . VAL A 1 374 ? 25.200 -34.590 -20.625 1.00 34.04 ? 401 VAL A CG1 1 
ATOM   2933 C CG2 . VAL A 1 374 ? 24.981 -32.951 -22.503 1.00 31.83 ? 401 VAL A CG2 1 
ATOM   2934 N N   . ASP A 1 375 ? 27.527 -36.060 -22.198 1.00 27.20 ? 402 ASP A N   1 
ATOM   2935 C CA  . ASP A 1 375 ? 28.960 -35.855 -22.066 1.00 27.85 ? 402 ASP A CA  1 
ATOM   2936 C C   . ASP A 1 375 ? 29.747 -36.405 -23.256 1.00 30.67 ? 402 ASP A C   1 
ATOM   2937 O O   . ASP A 1 375 ? 30.886 -35.986 -23.491 1.00 30.34 ? 402 ASP A O   1 
ATOM   2938 C CB  . ASP A 1 375 ? 29.458 -36.367 -20.728 1.00 30.45 ? 402 ASP A CB  1 
ATOM   2939 C CG  . ASP A 1 375 ? 28.884 -35.640 -19.520 1.00 31.11 ? 402 ASP A CG  1 
ATOM   2940 O OD1 . ASP A 1 375 ? 28.976 -34.382 -19.453 1.00 33.60 ? 402 ASP A OD1 1 
ATOM   2941 O OD2 . ASP A 1 375 ? 28.378 -36.341 -18.647 1.00 34.70 ? 402 ASP A OD2 1 
ATOM   2942 N N   . ALA A 1 376 ? 29.130 -37.300 -24.039 1.00 33.42 ? 403 ALA A N   1 
ATOM   2943 C CA  . ALA A 1 376 ? 29.766 -37.806 -25.248 1.00 33.61 ? 403 ALA A CA  1 
ATOM   2944 C C   . ALA A 1 376 ? 30.117 -36.679 -26.220 1.00 33.10 ? 403 ALA A C   1 
ATOM   2945 O O   . ALA A 1 376 ? 31.021 -36.837 -27.031 1.00 36.32 ? 403 ALA A O   1 
ATOM   2946 C CB  . ALA A 1 376 ? 28.880 -38.833 -25.906 1.00 33.85 ? 403 ALA A CB  1 
ATOM   2947 N N   . HIS A 1 377 ? 29.451 -35.520 -26.117 1.00 34.35 ? 404 HIS A N   1 
ATOM   2948 C CA  . HIS A 1 377 ? 29.443 -34.558 -27.206 1.00 30.94 ? 404 HIS A CA  1 
ATOM   2949 C C   . HIS A 1 377 ? 29.909 -33.154 -26.816 1.00 28.01 ? 404 HIS A C   1 
ATOM   2950 O O   . HIS A 1 377 ? 30.187 -32.344 -27.698 1.00 24.47 ? 404 HIS A O   1 
ATOM   2951 C CB  . HIS A 1 377 ? 28.038 -34.494 -27.818 1.00 32.79 ? 404 HIS A CB  1 
ATOM   2952 C CG  . HIS A 1 377 ? 28.059 -34.204 -29.284 1.00 36.25 ? 404 HIS A CG  1 
ATOM   2953 N ND1 . HIS A 1 377 ? 27.352 -34.973 -30.184 1.00 42.49 ? 404 HIS A ND1 1 
ATOM   2954 C CD2 . HIS A 1 377 ? 28.702 -33.291 -30.005 1.00 35.58 ? 404 HIS A CD2 1 
ATOM   2955 C CE1 . HIS A 1 377 ? 27.580 -34.521 -31.402 1.00 39.06 ? 404 HIS A CE1 1 
ATOM   2956 N NE2 . HIS A 1 377 ? 28.388 -33.492 -31.314 1.00 40.27 ? 404 HIS A NE2 1 
ATOM   2957 N N   . SER A 1 378 ? 30.002 -32.836 -25.522 1.00 26.27 ? 405 SER A N   1 
ATOM   2958 C CA  . SER A 1 378 ? 30.227 -31.461 -25.121 1.00 28.30 ? 405 SER A CA  1 
ATOM   2959 C C   . SER A 1 378 ? 31.669 -31.024 -25.372 1.00 24.77 ? 405 SER A C   1 
ATOM   2960 O O   . SER A 1 378 ? 31.890 -29.907 -25.834 1.00 24.70 ? 405 SER A O   1 
ATOM   2961 C CB  . SER A 1 378 ? 29.780 -31.227 -23.668 1.00 31.29 ? 405 SER A CB  1 
ATOM   2962 O OG  . SER A 1 378 ? 30.017 -32.393 -22.894 1.00 36.89 ? 405 SER A OG  1 
ATOM   2963 N N   . GLY A 1 379 ? 32.630 -31.908 -25.102 1.00 25.92 ? 406 GLY A N   1 
ATOM   2964 C CA  . GLY A 1 379 ? 34.041 -31.570 -25.186 1.00 27.90 ? 406 GLY A CA  1 
ATOM   2965 C C   . GLY A 1 379 ? 34.483 -31.116 -26.580 1.00 29.47 ? 406 GLY A C   1 
ATOM   2966 O O   . GLY A 1 379 ? 35.164 -30.095 -26.733 1.00 30.31 ? 406 GLY A O   1 
ATOM   2967 N N   . VAL A 1 380 ? 34.096 -31.858 -27.621 1.00 32.57 ? 407 VAL A N   1 
ATOM   2968 C CA  . VAL A 1 380 ? 34.555 -31.481 -28.957 1.00 30.70 ? 407 VAL A CA  1 
ATOM   2969 C C   . VAL A 1 380 ? 34.005 -30.115 -29.363 1.00 29.65 ? 407 VAL A C   1 
ATOM   2970 O O   . VAL A 1 380 ? 34.736 -29.346 -29.971 1.00 32.77 ? 407 VAL A O   1 
ATOM   2971 C CB  . VAL A 1 380 ? 34.254 -32.567 -29.990 1.00 30.96 ? 407 VAL A CB  1 
ATOM   2972 C CG1 . VAL A 1 380 ? 35.096 -33.783 -29.667 1.00 30.70 ? 407 VAL A CG1 1 
ATOM   2973 C CG2 . VAL A 1 380 ? 32.766 -32.915 -30.082 1.00 30.95 ? 407 VAL A CG2 1 
ATOM   2974 N N   . LEU A 1 381 ? 32.766 -29.773 -28.962 1.00 27.97 ? 408 LEU A N   1 
ATOM   2975 C CA  . LEU A 1 381 ? 32.235 -28.450 -29.247 1.00 28.24 ? 408 LEU A CA  1 
ATOM   2976 C C   . LEU A 1 381 ? 33.086 -27.377 -28.587 1.00 28.74 ? 408 LEU A C   1 
ATOM   2977 O O   . LEU A 1 381 ? 33.416 -26.376 -29.199 1.00 29.09 ? 408 LEU A O   1 
ATOM   2978 C CB  . LEU A 1 381 ? 30.775 -28.324 -28.814 1.00 28.77 ? 408 LEU A CB  1 
ATOM   2979 C CG  . LEU A 1 381 ? 29.843 -29.365 -29.431 1.00 28.18 ? 408 LEU A CG  1 
ATOM   2980 C CD1 . LEU A 1 381 ? 28.428 -29.267 -28.964 1.00 32.58 ? 408 LEU A CD1 1 
ATOM   2981 C CD2 . LEU A 1 381 ? 29.898 -29.256 -30.941 1.00 30.26 ? 408 LEU A CD2 1 
ATOM   2982 N N   . LEU A 1 382 ? 33.401 -27.571 -27.307 1.00 31.82 ? 409 LEU A N   1 
ATOM   2983 C CA  . LEU A 1 382 ? 34.067 -26.540 -26.531 1.00 29.23 ? 409 LEU A CA  1 
ATOM   2984 C C   . LEU A 1 382 ? 35.477 -26.349 -27.085 1.00 27.25 ? 409 LEU A C   1 
ATOM   2985 O O   . LEU A 1 382 ? 35.929 -25.219 -27.259 1.00 28.62 ? 409 LEU A O   1 
ATOM   2986 C CB  . LEU A 1 382 ? 34.089 -26.921 -25.047 1.00 26.56 ? 409 LEU A CB  1 
ATOM   2987 C CG  . LEU A 1 382 ? 32.752 -26.890 -24.298 1.00 24.46 ? 409 LEU A CG  1 
ATOM   2988 C CD1 . LEU A 1 382 ? 32.961 -27.580 -22.965 1.00 24.80 ? 409 LEU A CD1 1 
ATOM   2989 C CD2 . LEU A 1 382 ? 32.216 -25.493 -24.073 1.00 23.94 ? 409 LEU A CD2 1 
ATOM   2990 N N   . GLN A 1 383 ? 36.140 -27.479 -27.335 1.00 31.69 ? 410 GLN A N   1 
ATOM   2991 C CA  . GLN A 1 383 ? 37.496 -27.529 -27.862 1.00 34.30 ? 410 GLN A CA  1 
ATOM   2992 C C   . GLN A 1 383 ? 37.559 -26.861 -29.233 1.00 35.32 ? 410 GLN A C   1 
ATOM   2993 O O   . GLN A 1 383 ? 38.476 -26.079 -29.493 1.00 33.45 ? 410 GLN A O   1 
ATOM   2994 C CB  . GLN A 1 383 ? 37.914 -28.997 -27.919 1.00 34.61 ? 410 GLN A CB  1 
ATOM   2995 C CG  . GLN A 1 383 ? 39.380 -29.210 -28.270 1.00 42.90 ? 410 GLN A CG  1 
ATOM   2996 C CD  . GLN A 1 383 ? 40.084 -30.146 -27.312 1.00 50.22 ? 410 GLN A CD  1 
ATOM   2997 O OE1 . GLN A 1 383 ? 40.500 -31.246 -27.694 1.00 56.95 ? 410 GLN A OE1 1 
ATOM   2998 N NE2 . GLN A 1 383 ? 40.203 -29.730 -26.052 1.00 51.88 ? 410 GLN A NE2 1 
ATOM   2999 N N   . TYR A 1 384 ? 36.542 -27.122 -30.071 1.00 31.63 ? 411 TYR A N   1 
ATOM   3000 C CA  . TYR A 1 384 ? 36.464 -26.512 -31.388 1.00 34.64 ? 411 TYR A CA  1 
ATOM   3001 C C   . TYR A 1 384 ? 36.602 -24.996 -31.268 1.00 37.90 ? 411 TYR A C   1 
ATOM   3002 O O   . TYR A 1 384 ? 37.234 -24.384 -32.120 1.00 39.03 ? 411 TYR A O   1 
ATOM   3003 C CB  . TYR A 1 384 ? 35.172 -26.853 -32.137 1.00 33.52 ? 411 TYR A CB  1 
ATOM   3004 C CG  . TYR A 1 384 ? 35.090 -26.208 -33.510 1.00 36.60 ? 411 TYR A CG  1 
ATOM   3005 C CD1 . TYR A 1 384 ? 35.749 -26.760 -34.604 1.00 40.57 ? 411 TYR A CD1 1 
ATOM   3006 C CD2 . TYR A 1 384 ? 34.381 -25.030 -33.702 1.00 37.70 ? 411 TYR A CD2 1 
ATOM   3007 C CE1 . TYR A 1 384 ? 35.683 -26.169 -35.854 1.00 41.05 ? 411 TYR A CE1 1 
ATOM   3008 C CE2 . TYR A 1 384 ? 34.291 -24.436 -34.948 1.00 43.31 ? 411 TYR A CE2 1 
ATOM   3009 C CZ  . TYR A 1 384 ? 34.954 -25.005 -36.024 1.00 44.78 ? 411 TYR A CZ  1 
ATOM   3010 O OH  . TYR A 1 384 ? 34.895 -24.381 -37.230 1.00 46.26 ? 411 TYR A OH  1 
ATOM   3011 N N   . TYR A 1 385 ? 36.058 -24.375 -30.212 1.00 33.94 ? 412 TYR A N   1 
ATOM   3012 C CA  . TYR A 1 385 ? 36.067 -22.920 -30.158 1.00 32.75 ? 412 TYR A CA  1 
ATOM   3013 C C   . TYR A 1 385 ? 37.193 -22.385 -29.286 1.00 30.33 ? 412 TYR A C   1 
ATOM   3014 O O   . TYR A 1 385 ? 37.140 -21.228 -28.891 1.00 27.68 ? 412 TYR A O   1 
ATOM   3015 C CB  . TYR A 1 385 ? 34.746 -22.336 -29.641 1.00 36.09 ? 412 TYR A CB  1 
ATOM   3016 C CG  . TYR A 1 385 ? 33.635 -22.490 -30.657 1.00 34.96 ? 412 TYR A CG  1 
ATOM   3017 C CD1 . TYR A 1 385 ? 33.539 -21.639 -31.750 1.00 35.55 ? 412 TYR A CD1 1 
ATOM   3018 C CD2 . TYR A 1 385 ? 32.751 -23.548 -30.572 1.00 36.75 ? 412 TYR A CD2 1 
ATOM   3019 C CE1 . TYR A 1 385 ? 32.551 -21.825 -32.702 1.00 35.02 ? 412 TYR A CE1 1 
ATOM   3020 C CE2 . TYR A 1 385 ? 31.749 -23.729 -31.503 1.00 34.77 ? 412 TYR A CE2 1 
ATOM   3021 C CZ  . TYR A 1 385 ? 31.654 -22.869 -32.573 1.00 33.36 ? 412 TYR A CZ  1 
ATOM   3022 O OH  . TYR A 1 385 ? 30.649 -23.083 -33.468 1.00 38.36 ? 412 TYR A OH  1 
ATOM   3023 N N   . GLY A 1 386 ? 38.198 -23.211 -28.986 1.00 31.76 ? 413 GLY A N   1 
ATOM   3024 C CA  . GLY A 1 386 ? 39.341 -22.748 -28.221 1.00 32.96 ? 413 GLY A CA  1 
ATOM   3025 C C   . GLY A 1 386 ? 39.174 -22.918 -26.705 1.00 34.85 ? 413 GLY A C   1 
ATOM   3026 O O   . GLY A 1 386 ? 39.983 -22.410 -25.941 1.00 34.89 ? 413 GLY A O   1 
ATOM   3027 N N   . MET A 1 387 ? 38.129 -23.620 -26.260 1.00 31.98 ? 414 MET A N   1 
ATOM   3028 C CA  . MET A 1 387 ? 37.927 -23.848 -24.838 1.00 30.95 ? 414 MET A CA  1 
ATOM   3029 C C   . MET A 1 387 ? 38.563 -25.200 -24.547 1.00 24.74 ? 414 MET A C   1 
ATOM   3030 O O   . MET A 1 387 ? 37.915 -26.238 -24.601 1.00 27.61 ? 414 MET A O   1 
ATOM   3031 C CB  . MET A 1 387 ? 36.434 -23.667 -24.526 1.00 33.92 ? 414 MET A CB  1 
ATOM   3032 C CG  . MET A 1 387 ? 35.938 -24.225 -23.224 1.00 39.01 ? 414 MET A CG  1 
ATOM   3033 S SD  . MET A 1 387 ? 36.480 -23.310 -21.778 1.00 39.11 ? 414 MET A SD  1 
ATOM   3034 C CE  . MET A 1 387 ? 35.846 -21.629 -21.838 1.00 31.15 ? 414 MET A CE  1 
ATOM   3035 N N   . THR A 1 388 ? 39.885 -25.179 -24.374 1.00 26.13 ? 415 THR A N   1 
ATOM   3036 C CA  . THR A 1 388 ? 40.697 -26.394 -24.389 1.00 28.87 ? 415 THR A CA  1 
ATOM   3037 C C   . THR A 1 388 ? 41.072 -26.848 -22.979 1.00 29.63 ? 415 THR A C   1 
ATOM   3038 O O   . THR A 1 388 ? 41.562 -27.963 -22.830 1.00 28.04 ? 415 THR A O   1 
ATOM   3039 C CB  . THR A 1 388 ? 41.971 -26.209 -25.216 1.00 31.21 ? 415 THR A CB  1 
ATOM   3040 O OG1 . THR A 1 388 ? 42.647 -25.050 -24.740 1.00 32.43 ? 415 THR A OG1 1 
ATOM   3041 C CG2 . THR A 1 388 ? 41.690 -26.065 -26.702 1.00 34.76 ? 415 THR A CG2 1 
ATOM   3042 N N   . GLU A 1 389 ? 40.828 -26.009 -21.955 1.00 29.27 ? 416 GLU A N   1 
ATOM   3043 C CA  . GLU A 1 389 ? 41.223 -26.320 -20.592 1.00 28.11 ? 416 GLU A CA  1 
ATOM   3044 C C   . GLU A 1 389 ? 40.176 -27.240 -19.971 1.00 29.83 ? 416 GLU A C   1 
ATOM   3045 O O   . GLU A 1 389 ? 39.140 -26.793 -19.457 1.00 29.15 ? 416 GLU A O   1 
ATOM   3046 C CB  . GLU A 1 389 ? 41.460 -25.011 -19.838 1.00 29.59 ? 416 GLU A CB  1 
ATOM   3047 C CG  . GLU A 1 389 ? 42.454 -24.081 -20.541 1.00 28.10 ? 416 GLU A CG  1 
ATOM   3048 C CD  . GLU A 1 389 ? 41.871 -23.065 -21.535 1.00 30.70 ? 416 GLU A CD  1 
ATOM   3049 O OE1 . GLU A 1 389 ? 40.641 -23.023 -21.824 1.00 25.93 ? 416 GLU A OE1 1 
ATOM   3050 O OE2 . GLU A 1 389 ? 42.700 -22.259 -22.034 1.00 33.35 ? 416 GLU A OE2 1 
ATOM   3051 N N   . MET A 1 390 ? 40.456 -28.545 -20.042 1.00 27.20 ? 417 MET A N   1 
ATOM   3052 C CA  . MET A 1 390 ? 39.483 -29.555 -19.703 1.00 27.26 ? 417 MET A CA  1 
ATOM   3053 C C   . MET A 1 390 ? 39.133 -29.477 -18.212 1.00 29.84 ? 417 MET A C   1 
ATOM   3054 O O   . MET A 1 390 ? 38.009 -29.794 -17.847 1.00 26.35 ? 417 MET A O   1 
ATOM   3055 C CB  . MET A 1 390 ? 39.992 -30.955 -20.047 1.00 28.26 ? 417 MET A CB  1 
ATOM   3056 C CG  . MET A 1 390 ? 40.157 -31.223 -21.517 1.00 32.47 ? 417 MET A CG  1 
ATOM   3057 S SD  . MET A 1 390 ? 40.448 -32.984 -21.781 1.00 38.16 ? 417 MET A SD  1 
ATOM   3058 C CE  . MET A 1 390 ? 41.854 -33.339 -20.716 1.00 45.12 ? 417 MET A CE  1 
ATOM   3059 N N   . ASN A 1 391 ? 40.074 -29.070 -17.344 1.00 26.94 ? 418 ASN A N   1 
ATOM   3060 C CA  . ASN A 1 391 ? 39.788 -29.004 -15.917 1.00 28.34 ? 418 ASN A CA  1 
ATOM   3061 C C   . ASN A 1 391 ? 38.665 -28.013 -15.634 1.00 29.50 ? 418 ASN A C   1 
ATOM   3062 O O   . ASN A 1 391 ? 37.969 -28.152 -14.620 1.00 35.92 ? 418 ASN A O   1 
ATOM   3063 C CB  . ASN A 1 391 ? 41.005 -28.604 -15.086 1.00 30.56 ? 418 ASN A CB  1 
ATOM   3064 C CG  . ASN A 1 391 ? 41.947 -29.764 -14.926 1.00 34.15 ? 418 ASN A CG  1 
ATOM   3065 O OD1 . ASN A 1 391 ? 41.565 -30.905 -15.190 1.00 31.23 ? 418 ASN A OD1 1 
ATOM   3066 N ND2 . ASN A 1 391 ? 43.174 -29.486 -14.530 1.00 39.09 ? 418 ASN A ND2 1 
ATOM   3067 N N   . TYR A 1 392 ? 38.501 -27.037 -16.534 1.00 23.02 ? 419 TYR A N   1 
ATOM   3068 C CA  . TYR A 1 392 ? 37.555 -25.954 -16.339 1.00 24.67 ? 419 TYR A CA  1 
ATOM   3069 C C   . TYR A 1 392 ? 36.133 -26.343 -16.746 1.00 23.45 ? 419 TYR A C   1 
ATOM   3070 O O   . TYR A 1 392 ? 35.197 -25.666 -16.358 1.00 26.11 ? 419 TYR A O   1 
ATOM   3071 C CB  . TYR A 1 392 ? 37.967 -24.733 -17.161 1.00 22.51 ? 419 TYR A CB  1 
ATOM   3072 C CG  . TYR A 1 392 ? 37.127 -23.505 -16.890 1.00 20.65 ? 419 TYR A CG  1 
ATOM   3073 C CD1 . TYR A 1 392 ? 37.338 -22.740 -15.753 1.00 20.22 ? 419 TYR A CD1 1 
ATOM   3074 C CD2 . TYR A 1 392 ? 36.135 -23.096 -17.773 1.00 22.47 ? 419 TYR A CD2 1 
ATOM   3075 C CE1 . TYR A 1 392 ? 36.583 -21.614 -15.493 1.00 19.63 ? 419 TYR A CE1 1 
ATOM   3076 C CE2 . TYR A 1 392 ? 35.378 -21.964 -17.527 1.00 19.16 ? 419 TYR A CE2 1 
ATOM   3077 C CZ  . TYR A 1 392 ? 35.597 -21.231 -16.378 1.00 18.74 ? 419 TYR A CZ  1 
ATOM   3078 O OH  . TYR A 1 392 ? 34.851 -20.125 -16.109 1.00 19.92 ? 419 TYR A OH  1 
ATOM   3079 N N   . TYR A 1 393 ? 35.977 -27.402 -17.537 1.00 21.81 ? 420 TYR A N   1 
ATOM   3080 C CA  . TYR A 1 393 ? 34.700 -27.719 -18.158 1.00 22.49 ? 420 TYR A CA  1 
ATOM   3081 C C   . TYR A 1 393 ? 33.590 -27.876 -17.132 1.00 23.96 ? 420 TYR A C   1 
ATOM   3082 O O   . TYR A 1 393 ? 32.446 -27.480 -17.396 1.00 24.74 ? 420 TYR A O   1 
ATOM   3083 C CB  . TYR A 1 393 ? 34.798 -28.982 -19.015 1.00 23.03 ? 420 TYR A CB  1 
ATOM   3084 C CG  . TYR A 1 393 ? 35.589 -28.818 -20.314 1.00 24.23 ? 420 TYR A CG  1 
ATOM   3085 C CD1 . TYR A 1 393 ? 36.271 -27.650 -20.653 1.00 24.62 ? 420 TYR A CD1 1 
ATOM   3086 C CD2 . TYR A 1 393 ? 35.671 -29.879 -21.192 1.00 27.68 ? 420 TYR A CD2 1 
ATOM   3087 C CE1 . TYR A 1 393 ? 36.998 -27.554 -21.842 1.00 29.57 ? 420 TYR A CE1 1 
ATOM   3088 C CE2 . TYR A 1 393 ? 36.367 -29.793 -22.382 1.00 29.77 ? 420 TYR A CE2 1 
ATOM   3089 C CZ  . TYR A 1 393 ? 37.030 -28.635 -22.715 1.00 30.11 ? 420 TYR A CZ  1 
ATOM   3090 O OH  . TYR A 1 393 ? 37.668 -28.676 -23.914 1.00 33.92 ? 420 TYR A OH  1 
ATOM   3091 N N   . THR A 1 394 ? 33.908 -28.456 -15.971 1.00 23.40 ? 421 THR A N   1 
ATOM   3092 C CA  . THR A 1 394 ? 32.861 -28.699 -14.991 1.00 22.78 ? 421 THR A CA  1 
ATOM   3093 C C   . THR A 1 394 ? 32.377 -27.399 -14.370 1.00 21.38 ? 421 THR A C   1 
ATOM   3094 O O   . THR A 1 394 ? 31.238 -27.341 -13.902 1.00 22.06 ? 421 THR A O   1 
ATOM   3095 C CB  . THR A 1 394 ? 33.265 -29.689 -13.915 1.00 22.95 ? 421 THR A CB  1 
ATOM   3096 O OG1 . THR A 1 394 ? 33.702 -30.788 -14.703 1.00 24.31 ? 421 THR A OG1 1 
ATOM   3097 C CG2 . THR A 1 394 ? 32.057 -30.072 -13.076 1.00 23.94 ? 421 THR A CG2 1 
ATOM   3098 N N   . VAL A 1 395 ? 33.187 -26.346 -14.431 1.00 18.92 ? 422 VAL A N   1 
ATOM   3099 C CA  . VAL A 1 395 ? 32.694 -25.036 -14.040 1.00 20.53 ? 422 VAL A CA  1 
ATOM   3100 C C   . VAL A 1 395 ? 31.531 -24.608 -14.942 1.00 21.98 ? 422 VAL A C   1 
ATOM   3101 O O   . VAL A 1 395 ? 30.540 -24.074 -14.464 1.00 17.91 ? 422 VAL A O   1 
ATOM   3102 C CB  . VAL A 1 395 ? 33.828 -24.001 -14.032 1.00 22.81 ? 422 VAL A CB  1 
ATOM   3103 C CG1 . VAL A 1 395 ? 33.330 -22.607 -13.649 1.00 21.24 ? 422 VAL A CG1 1 
ATOM   3104 C CG2 . VAL A 1 395 ? 34.940 -24.442 -13.096 1.00 22.04 ? 422 VAL A CG2 1 
ATOM   3105 N N   . LEU A 1 396 ? 31.614 -24.859 -16.251 1.00 22.66 ? 423 LEU A N   1 
ATOM   3106 C CA  . LEU A 1 396 ? 30.546 -24.411 -17.130 1.00 22.98 ? 423 LEU A CA  1 
ATOM   3107 C C   . LEU A 1 396 ? 29.262 -25.128 -16.751 1.00 22.55 ? 423 LEU A C   1 
ATOM   3108 O O   . LEU A 1 396 ? 28.211 -24.515 -16.674 1.00 24.74 ? 423 LEU A O   1 
ATOM   3109 C CB  . LEU A 1 396 ? 30.879 -24.637 -18.602 1.00 23.65 ? 423 LEU A CB  1 
ATOM   3110 C CG  . LEU A 1 396 ? 32.091 -23.857 -19.109 1.00 24.16 ? 423 LEU A CG  1 
ATOM   3111 C CD1 . LEU A 1 396 ? 32.528 -24.373 -20.486 1.00 25.37 ? 423 LEU A CD1 1 
ATOM   3112 C CD2 . LEU A 1 396 ? 31.792 -22.371 -19.177 1.00 25.95 ? 423 LEU A CD2 1 
ATOM   3113 N N   . PHE A 1 397 ? 29.389 -26.427 -16.519 1.00 20.96 ? 424 PHE A N   1 
ATOM   3114 C CA  . PHE A 1 397 ? 28.302 -27.249 -16.061 1.00 22.04 ? 424 PHE A CA  1 
ATOM   3115 C C   . PHE A 1 397 ? 27.710 -26.645 -14.797 1.00 21.63 ? 424 PHE A C   1 
ATOM   3116 O O   . PHE A 1 397 ? 26.496 -26.571 -14.672 1.00 19.39 ? 424 PHE A O   1 
ATOM   3117 C CB  . PHE A 1 397 ? 28.891 -28.646 -15.856 1.00 21.82 ? 424 PHE A CB  1 
ATOM   3118 C CG  . PHE A 1 397 ? 27.934 -29.816 -15.798 1.00 23.62 ? 424 PHE A CG  1 
ATOM   3119 C CD1 . PHE A 1 397 ? 26.579 -29.647 -15.546 1.00 27.73 ? 424 PHE A CD1 1 
ATOM   3120 C CD2 . PHE A 1 397 ? 28.410 -31.109 -15.970 1.00 25.49 ? 424 PHE A CD2 1 
ATOM   3121 C CE1 . PHE A 1 397 ? 25.719 -30.736 -15.509 1.00 27.50 ? 424 PHE A CE1 1 
ATOM   3122 C CE2 . PHE A 1 397 ? 27.548 -32.197 -15.929 1.00 28.14 ? 424 PHE A CE2 1 
ATOM   3123 C CZ  . PHE A 1 397 ? 26.204 -32.006 -15.706 1.00 28.88 ? 424 PHE A CZ  1 
ATOM   3124 N N   . GLY A 1 398 ? 28.583 -26.268 -13.853 1.00 20.38 ? 425 GLY A N   1 
ATOM   3125 C CA  . GLY A 1 398 ? 28.149 -25.743 -12.580 1.00 21.13 ? 425 GLY A CA  1 
ATOM   3126 C C   . GLY A 1 398 ? 27.313 -24.477 -12.769 1.00 21.43 ? 425 GLY A C   1 
ATOM   3127 O O   . GLY A 1 398 ? 26.256 -24.319 -12.172 1.00 22.98 ? 425 GLY A O   1 
ATOM   3128 N N   . VAL A 1 399 ? 27.823 -23.550 -13.570 1.00 20.72 ? 426 VAL A N   1 
ATOM   3129 C CA  . VAL A 1 399 ? 27.111 -22.299 -13.826 1.00 22.94 ? 426 VAL A CA  1 
ATOM   3130 C C   . VAL A 1 399 ? 25.729 -22.592 -14.417 1.00 20.86 ? 426 VAL A C   1 
ATOM   3131 O O   . VAL A 1 399 ? 24.748 -21.939 -14.089 1.00 21.24 ? 426 VAL A O   1 
ATOM   3132 C CB  . VAL A 1 399 ? 27.952 -21.441 -14.785 1.00 23.42 ? 426 VAL A CB  1 
ATOM   3133 C CG1 . VAL A 1 399 ? 27.193 -20.209 -15.228 1.00 27.02 ? 426 VAL A CG1 1 
ATOM   3134 C CG2 . VAL A 1 399 ? 29.302 -21.076 -14.195 1.00 23.61 ? 426 VAL A CG2 1 
ATOM   3135 N N   . SER A 1 400 ? 25.656 -23.588 -15.309 1.00 20.08 ? 427 SER A N   1 
ATOM   3136 C CA  . SER A 1 400 ? 24.399 -24.021 -15.888 1.00 20.52 ? 427 SER A CA  1 
ATOM   3137 C C   . SER A 1 400 ? 23.459 -24.533 -14.797 1.00 22.48 ? 427 SER A C   1 
ATOM   3138 O O   . SER A 1 400 ? 22.315 -24.090 -14.697 1.00 20.77 ? 427 SER A O   1 
ATOM   3139 C CB  . SER A 1 400 ? 24.619 -25.092 -16.913 1.00 20.71 ? 427 SER A CB  1 
ATOM   3140 O OG  . SER A 1 400 ? 23.380 -25.544 -17.412 1.00 20.95 ? 427 SER A OG  1 
ATOM   3141 N N   . ARG A 1 401 ? 23.980 -25.462 -13.988 1.00 21.12 ? 428 ARG A N   1 
ATOM   3142 C CA  . ARG A 1 401 ? 23.178 -26.250 -13.077 1.00 21.61 ? 428 ARG A CA  1 
ATOM   3143 C C   . ARG A 1 401 ? 22.584 -25.378 -11.973 1.00 21.61 ? 428 ARG A C   1 
ATOM   3144 O O   . ARG A 1 401 ? 21.581 -25.778 -11.389 1.00 20.38 ? 428 ARG A O   1 
ATOM   3145 C CB  . ARG A 1 401 ? 24.018 -27.448 -12.612 1.00 19.49 ? 428 ARG A CB  1 
ATOM   3146 C CG  . ARG A 1 401 ? 23.295 -28.346 -11.618 1.00 22.90 ? 428 ARG A CG  1 
ATOM   3147 C CD  . ARG A 1 401 ? 21.953 -28.915 -12.127 1.00 23.24 ? 428 ARG A CD  1 
ATOM   3148 N NE  . ARG A 1 401 ? 22.086 -29.582 -13.425 1.00 23.17 ? 428 ARG A NE  1 
ATOM   3149 C CZ  . ARG A 1 401 ? 22.240 -30.886 -13.651 1.00 25.02 ? 428 ARG A CZ  1 
ATOM   3150 N NH1 . ARG A 1 401 ? 22.549 -31.703 -12.673 1.00 25.16 ? 428 ARG A NH1 1 
ATOM   3151 N NH2 . ARG A 1 401 ? 22.201 -31.359 -14.891 1.00 28.11 ? 428 ARG A NH2 1 
ATOM   3152 N N   . ALA A 1 402 ? 23.187 -24.206 -11.697 1.00 21.21 ? 429 ALA A N   1 
ATOM   3153 C CA  . ALA A 1 402 ? 22.603 -23.229 -10.780 1.00 21.70 ? 429 ALA A CA  1 
ATOM   3154 C C   . ALA A 1 402 ? 21.149 -22.951 -11.134 1.00 21.46 ? 429 ALA A C   1 
ATOM   3155 O O   . ALA A 1 402 ? 20.301 -22.839 -10.255 1.00 19.91 ? 429 ALA A O   1 
ATOM   3156 C CB  . ALA A 1 402 ? 23.372 -21.927 -10.781 1.00 21.89 ? 429 ALA A CB  1 
ATOM   3157 N N   . LEU A 1 403 ? 20.868 -22.873 -12.427 1.00 21.50 ? 430 LEU A N   1 
ATOM   3158 C CA  . LEU A 1 403 ? 19.563 -22.429 -12.880 1.00 22.94 ? 430 LEU A CA  1 
ATOM   3159 C C   . LEU A 1 403 ? 18.496 -23.370 -12.353 1.00 21.46 ? 430 LEU A C   1 
ATOM   3160 O O   . LEU A 1 403 ? 17.520 -22.925 -11.763 1.00 24.11 ? 430 LEU A O   1 
ATOM   3161 C CB  . LEU A 1 403 ? 19.540 -22.329 -14.405 1.00 22.47 ? 430 LEU A CB  1 
ATOM   3162 C CG  . LEU A 1 403 ? 20.527 -21.331 -15.010 1.00 22.26 ? 430 LEU A CG  1 
ATOM   3163 C CD1 . LEU A 1 403 ? 20.469 -21.368 -16.503 1.00 22.87 ? 430 LEU A CD1 1 
ATOM   3164 C CD2 . LEU A 1 403 ? 20.286 -19.926 -14.503 1.00 22.35 ? 430 LEU A CD2 1 
ATOM   3165 N N   . GLY A 1 404 ? 18.691 -24.663 -12.577 1.00 23.58 ? 431 GLY A N   1 
ATOM   3166 C CA  . GLY A 1 404 ? 17.706 -25.648 -12.189 1.00 21.76 ? 431 GLY A CA  1 
ATOM   3167 C C   . GLY A 1 404 ? 17.649 -25.792 -10.675 1.00 22.20 ? 431 GLY A C   1 
ATOM   3168 O O   . GLY A 1 404 ? 16.571 -25.862 -10.098 1.00 22.86 ? 431 GLY A O   1 
ATOM   3169 N N   . VAL A 1 405 ? 18.808 -25.907 -10.022 1.00 22.33 ? 432 VAL A N   1 
ATOM   3170 C CA  . VAL A 1 405 ? 18.805 -26.227 -8.596  1.00 20.01 ? 432 VAL A CA  1 
ATOM   3171 C C   . VAL A 1 405 ? 18.282 -25.034 -7.803  1.00 17.84 ? 432 VAL A C   1 
ATOM   3172 O O   . VAL A 1 405 ? 17.660 -25.212 -6.768  1.00 17.88 ? 432 VAL A O   1 
ATOM   3173 C CB  . VAL A 1 405 ? 20.143 -26.756 -8.029  1.00 21.87 ? 432 VAL A CB  1 
ATOM   3174 C CG1 . VAL A 1 405 ? 20.630 -28.004 -8.769  1.00 23.52 ? 432 VAL A CG1 1 
ATOM   3175 C CG2 . VAL A 1 405 ? 21.237 -25.708 -7.978  1.00 20.13 ? 432 VAL A CG2 1 
ATOM   3176 N N   . LEU A 1 406 ? 18.548 -23.808 -8.256  1.00 18.60 ? 433 LEU A N   1 
ATOM   3177 C CA  . LEU A 1 406 ? 18.073 -22.655 -7.517  1.00 18.70 ? 433 LEU A CA  1 
ATOM   3178 C C   . LEU A 1 406 ? 16.597 -22.418 -7.800  1.00 19.56 ? 433 LEU A C   1 
ATOM   3179 O O   . LEU A 1 406 ? 15.875 -21.968 -6.925  1.00 20.92 ? 433 LEU A O   1 
ATOM   3180 C CB  . LEU A 1 406 ? 18.918 -21.416 -7.777  1.00 18.24 ? 433 LEU A CB  1 
ATOM   3181 C CG  . LEU A 1 406 ? 20.364 -21.514 -7.305  1.00 17.27 ? 433 LEU A CG  1 
ATOM   3182 C CD1 . LEU A 1 406 ? 21.136 -20.374 -7.867  1.00 18.26 ? 433 LEU A CD1 1 
ATOM   3183 C CD2 . LEU A 1 406 ? 20.473 -21.505 -5.819  1.00 18.01 ? 433 LEU A CD2 1 
ATOM   3184 N N   . ALA A 1 407 ? 16.146 -22.692 -9.025  1.00 22.88 ? 434 ALA A N   1 
ATOM   3185 C CA  . ALA A 1 407 ? 14.722 -22.632 -9.333  1.00 21.80 ? 434 ALA A CA  1 
ATOM   3186 C C   . ALA A 1 407 ? 13.955 -23.472 -8.330  1.00 21.24 ? 434 ALA A C   1 
ATOM   3187 O O   . ALA A 1 407 ? 12.976 -23.014 -7.755  1.00 22.90 ? 434 ALA A O   1 
ATOM   3188 C CB  . ALA A 1 407 ? 14.443 -23.123 -10.729 1.00 21.31 ? 434 ALA A CB  1 
ATOM   3189 N N   . GLN A 1 408 ? 14.419 -24.709 -8.150  1.00 20.96 ? 435 GLN A N   1 
ATOM   3190 C CA  . GLN A 1 408 ? 13.738 -25.668 -7.295  1.00 22.24 ? 435 GLN A CA  1 
ATOM   3191 C C   . GLN A 1 408 ? 13.857 -25.280 -5.823  1.00 22.27 ? 435 GLN A C   1 
ATOM   3192 O O   . GLN A 1 408 ? 12.887 -25.448 -5.076  1.00 21.60 ? 435 GLN A O   1 
ATOM   3193 C CB  . GLN A 1 408 ? 14.296 -27.076 -7.435  1.00 23.07 ? 435 GLN A CB  1 
ATOM   3194 C CG  . GLN A 1 408 ? 13.720 -28.059 -6.428  1.00 24.23 ? 435 GLN A CG  1 
ATOM   3195 C CD  . GLN A 1 408 ? 12.208 -28.124 -6.494  1.00 25.25 ? 435 GLN A CD  1 
ATOM   3196 O OE1 . GLN A 1 408 ? 11.611 -28.063 -7.571  1.00 27.05 ? 435 GLN A OE1 1 
ATOM   3197 N NE2 . GLN A 1 408 ? 11.574 -28.220 -5.337  1.00 23.29 ? 435 GLN A NE2 1 
ATOM   3198 N N   . LEU A 1 409 ? 15.030 -24.736 -5.423  1.00 21.12 ? 436 LEU A N   1 
ATOM   3199 C CA  . LEU A 1 409 ? 15.238 -24.312 -4.046  1.00 21.43 ? 436 LEU A CA  1 
ATOM   3200 C C   . LEU A 1 409 ? 14.165 -23.300 -3.640  1.00 20.36 ? 436 LEU A C   1 
ATOM   3201 O O   . LEU A 1 409 ? 13.692 -23.300 -2.504  1.00 18.57 ? 436 LEU A O   1 
ATOM   3202 C CB  . LEU A 1 409 ? 16.626 -23.693 -3.874  1.00 23.71 ? 436 LEU A CB  1 
ATOM   3203 C CG  . LEU A 1 409 ? 17.038 -23.384 -2.433  1.00 22.36 ? 436 LEU A CG  1 
ATOM   3204 C CD1 . LEU A 1 409 ? 17.251 -24.642 -1.565  1.00 24.90 ? 436 LEU A CD1 1 
ATOM   3205 C CD2 . LEU A 1 409 ? 18.306 -22.568 -2.461  1.00 22.96 ? 436 LEU A CD2 1 
ATOM   3206 N N   . ILE A 1 410 ? 13.839 -22.384 -4.546  1.00 20.70 ? 437 ILE A N   1 
ATOM   3207 C CA  . ILE A 1 410 ? 12.825 -21.381 -4.271  1.00 22.64 ? 437 ILE A CA  1 
ATOM   3208 C C   . ILE A 1 410 ? 11.508 -22.083 -3.972  1.00 22.52 ? 437 ILE A C   1 
ATOM   3209 O O   . ILE A 1 410 ? 10.826 -21.730 -3.020  1.00 27.10 ? 437 ILE A O   1 
ATOM   3210 C CB  . ILE A 1 410 ? 12.690 -20.399 -5.450  1.00 23.87 ? 437 ILE A CB  1 
ATOM   3211 C CG1 . ILE A 1 410 ? 13.904 -19.495 -5.552  1.00 23.63 ? 437 ILE A CG1 1 
ATOM   3212 C CG2 . ILE A 1 410 ? 11.427 -19.562 -5.340  1.00 23.34 ? 437 ILE A CG2 1 
ATOM   3213 C CD1 . ILE A 1 410 ? 14.082 -18.861 -6.920  1.00 23.42 ? 437 ILE A CD1 1 
ATOM   3214 N N   . TRP A 1 411 ? 11.162 -23.077 -4.791  1.00 24.16 ? 438 TRP A N   1 
ATOM   3215 C CA  . TRP A 1 411 ? 9.904  -23.788 -4.652  1.00 23.43 ? 438 TRP A CA  1 
ATOM   3216 C C   . TRP A 1 411 ? 9.886  -24.664 -3.402  1.00 26.54 ? 438 TRP A C   1 
ATOM   3217 O O   . TRP A 1 411 ? 8.852  -24.743 -2.744  1.00 27.17 ? 438 TRP A O   1 
ATOM   3218 C CB  . TRP A 1 411 ? 9.618  -24.599 -5.922  1.00 22.88 ? 438 TRP A CB  1 
ATOM   3219 C CG  . TRP A 1 411 ? 8.948  -23.724 -6.923  1.00 24.08 ? 438 TRP A CG  1 
ATOM   3220 C CD1 . TRP A 1 411 ? 9.503  -23.057 -7.971  1.00 26.47 ? 438 TRP A CD1 1 
ATOM   3221 C CD2 . TRP A 1 411 ? 7.562  -23.327 -6.869  1.00 25.55 ? 438 TRP A CD2 1 
ATOM   3222 N NE1 . TRP A 1 411 ? 8.546  -22.316 -8.608  1.00 25.96 ? 438 TRP A NE1 1 
ATOM   3223 C CE2 . TRP A 1 411 ? 7.349  -22.458 -7.953  1.00 25.93 ? 438 TRP A CE2 1 
ATOM   3224 C CE3 . TRP A 1 411 ? 6.492  -23.639 -6.026  1.00 26.40 ? 438 TRP A CE3 1 
ATOM   3225 C CZ2 . TRP A 1 411 ? 6.104  -21.898 -8.212  1.00 26.69 ? 438 TRP A CZ2 1 
ATOM   3226 C CZ3 . TRP A 1 411 ? 5.269  -23.043 -6.251  1.00 24.63 ? 438 TRP A CZ3 1 
ATOM   3227 C CH2 . TRP A 1 411 ? 5.078  -22.213 -7.351  1.00 28.06 ? 438 TRP A CH2 1 
ATOM   3228 N N   . SER A 1 412 ? 11.023 -25.283 -3.057  1.00 23.77 ? 439 SER A N   1 
ATOM   3229 C CA  . SER A 1 412 ? 11.109 -26.121 -1.864  1.00 22.78 ? 439 SER A CA  1 
ATOM   3230 C C   . SER A 1 412 ? 10.807 -25.303 -0.605  1.00 23.97 ? 439 SER A C   1 
ATOM   3231 O O   . SER A 1 412 ? 10.177 -25.797 0.343   1.00 21.75 ? 439 SER A O   1 
ATOM   3232 C CB  . SER A 1 412 ? 12.466 -26.787 -1.762  1.00 23.26 ? 439 SER A CB  1 
ATOM   3233 O OG  . SER A 1 412 ? 12.723 -27.632 -2.887  1.00 22.46 ? 439 SER A OG  1 
ATOM   3234 N N   . ARG A 1 413 ? 11.292 -24.055 -0.592  1.00 20.99 ? 440 ARG A N   1 
ATOM   3235 C CA  . ARG A 1 413 ? 11.068 -23.165 0.525   1.00 21.13 ? 440 ARG A CA  1 
ATOM   3236 C C   . ARG A 1 413 ? 9.662  -22.593 0.454   1.00 19.37 ? 440 ARG A C   1 
ATOM   3237 O O   . ARG A 1 413 ? 9.010  -22.481 1.488   1.00 20.91 ? 440 ARG A O   1 
ATOM   3238 C CB  . ARG A 1 413 ? 12.129 -22.063 0.610   1.00 22.33 ? 440 ARG A CB  1 
ATOM   3239 C CG  . ARG A 1 413 ? 13.525 -22.612 0.866   1.00 23.34 ? 440 ARG A CG  1 
ATOM   3240 C CD  . ARG A 1 413 ? 13.714 -23.240 2.236   1.00 22.78 ? 440 ARG A CD  1 
ATOM   3241 N NE  . ARG A 1 413 ? 13.216 -24.609 2.375   1.00 23.87 ? 440 ARG A NE  1 
ATOM   3242 C CZ  . ARG A 1 413 ? 13.749 -25.711 1.859   1.00 23.62 ? 440 ARG A CZ  1 
ATOM   3243 N NH1 . ARG A 1 413 ? 14.771 -25.615 1.029   1.00 22.42 ? 440 ARG A NH1 1 
ATOM   3244 N NH2 . ARG A 1 413 ? 13.222 -26.899 2.140   1.00 23.66 ? 440 ARG A NH2 1 
ATOM   3245 N N   . ALA A 1 414 ? 9.144  -22.342 -0.750  1.00 20.84 ? 441 ALA A N   1 
ATOM   3246 C CA  . ALA A 1 414 ? 7.775  -21.818 -0.871  1.00 21.86 ? 441 ALA A CA  1 
ATOM   3247 C C   . ALA A 1 414 ? 6.753  -22.865 -0.425  1.00 22.25 ? 441 ALA A C   1 
ATOM   3248 O O   . ALA A 1 414 ? 5.701  -22.544 0.142   1.00 22.92 ? 441 ALA A O   1 
ATOM   3249 C CB  . ALA A 1 414 ? 7.512  -21.361 -2.276  1.00 22.32 ? 441 ALA A CB  1 
ATOM   3250 N N   . LEU A 1 415 ? 7.057  -24.138 -0.696  1.00 22.97 ? 442 LEU A N   1 
ATOM   3251 C CA  . LEU A 1 415 ? 6.152  -25.233 -0.371  1.00 22.40 ? 442 LEU A CA  1 
ATOM   3252 C C   . LEU A 1 415 ? 6.411  -25.753 1.043   1.00 24.05 ? 442 LEU A C   1 
ATOM   3253 O O   . LEU A 1 415 ? 5.707  -26.642 1.501   1.00 22.97 ? 442 LEU A O   1 
ATOM   3254 C CB  . LEU A 1 415 ? 6.274  -26.318 -1.434  1.00 20.29 ? 442 LEU A CB  1 
ATOM   3255 C CG  . LEU A 1 415 ? 6.008  -25.852 -2.865  1.00 19.78 ? 442 LEU A CG  1 
ATOM   3256 C CD1 . LEU A 1 415 ? 6.216  -26.924 -3.893  1.00 20.87 ? 442 LEU A CD1 1 
ATOM   3257 C CD2 . LEU A 1 415 ? 4.571  -25.309 -2.976  1.00 21.35 ? 442 LEU A CD2 1 
ATOM   3258 N N   . GLY A 1 416 ? 7.406  -25.179 1.728   1.00 21.18 ? 443 GLY A N   1 
ATOM   3259 C CA  . GLY A 1 416 ? 7.748  -25.569 3.081   1.00 24.20 ? 443 GLY A CA  1 
ATOM   3260 C C   . GLY A 1 416 ? 8.197  -27.026 3.200   1.00 22.34 ? 443 GLY A C   1 
ATOM   3261 O O   . GLY A 1 416 ? 7.935  -27.647 4.217   1.00 21.80 ? 443 GLY A O   1 
ATOM   3262 N N   . PHE A 1 417 ? 8.970  -27.539 2.240   1.00 24.11 ? 444 PHE A N   1 
ATOM   3263 C CA  . PHE A 1 417 ? 9.605  -28.848 2.401   1.00 21.85 ? 444 PHE A CA  1 
ATOM   3264 C C   . PHE A 1 417 ? 10.523 -28.888 3.621   1.00 22.18 ? 444 PHE A C   1 
ATOM   3265 O O   . PHE A 1 417 ? 11.269 -27.941 3.897   1.00 22.12 ? 444 PHE A O   1 
ATOM   3266 C CB  . PHE A 1 417 ? 10.400 -29.246 1.158   1.00 21.83 ? 444 PHE A CB  1 
ATOM   3267 C CG  . PHE A 1 417 ? 9.586  -29.472 -0.092  1.00 22.31 ? 444 PHE A CG  1 
ATOM   3268 C CD1 . PHE A 1 417 ? 8.193  -29.442 -0.066  1.00 25.05 ? 444 PHE A CD1 1 
ATOM   3269 C CD2 . PHE A 1 417 ? 10.215 -29.802 -1.286  1.00 23.21 ? 444 PHE A CD2 1 
ATOM   3270 C CE1 . PHE A 1 417 ? 7.469  -29.653 -1.231  1.00 24.53 ? 444 PHE A CE1 1 
ATOM   3271 C CE2 . PHE A 1 417 ? 9.478  -30.022 -2.431  1.00 23.50 ? 444 PHE A CE2 1 
ATOM   3272 C CZ  . PHE A 1 417 ? 8.111  -29.947 -2.400  1.00 23.13 ? 444 PHE A CZ  1 
ATOM   3273 N N   . PRO A 1 418 ? 10.434 -29.956 4.451   1.00 22.84 ? 445 PRO A N   1 
ATOM   3274 C CA  . PRO A 1 418 ? 11.148 -30.007 5.715   1.00 20.44 ? 445 PRO A CA  1 
ATOM   3275 C C   . PRO A 1 418 ? 12.529 -30.619 5.533   1.00 20.46 ? 445 PRO A C   1 
ATOM   3276 O O   . PRO A 1 418 ? 12.896 -31.026 4.439   1.00 20.24 ? 445 PRO A O   1 
ATOM   3277 C CB  . PRO A 1 418 ? 10.206 -30.877 6.572   1.00 24.75 ? 445 PRO A CB  1 
ATOM   3278 C CG  . PRO A 1 418 ? 9.639  -31.897 5.572   1.00 25.98 ? 445 PRO A CG  1 
ATOM   3279 C CD  . PRO A 1 418 ? 9.533  -31.115 4.267   1.00 26.58 ? 445 PRO A CD  1 
ATOM   3280 N N   . LEU A 1 419 ? 13.264 -30.677 6.636   1.00 20.63 ? 446 LEU A N   1 
ATOM   3281 C CA  . LEU A 1 419 ? 14.603 -31.229 6.661   1.00 24.13 ? 446 LEU A CA  1 
ATOM   3282 C C   . LEU A 1 419 ? 14.535 -32.627 6.057   1.00 24.24 ? 446 LEU A C   1 
ATOM   3283 O O   . LEU A 1 419 ? 13.585 -33.335 6.346   1.00 22.72 ? 446 LEU A O   1 
ATOM   3284 C CB  . LEU A 1 419 ? 14.991 -31.242 8.136   1.00 25.71 ? 446 LEU A CB  1 
ATOM   3285 C CG  . LEU A 1 419 ? 16.438 -31.613 8.463   1.00 29.72 ? 446 LEU A CG  1 
ATOM   3286 C CD1 . LEU A 1 419 ? 17.382 -30.476 8.170   1.00 28.26 ? 446 LEU A CD1 1 
ATOM   3287 C CD2 . LEU A 1 419 ? 16.535 -31.989 9.937   1.00 31.01 ? 446 LEU A CD2 1 
ATOM   3288 N N   . GLU A 1 420 ? 15.447 -32.961 5.127   1.00 23.69 ? 447 GLU A N   1 
ATOM   3289 C CA  . GLU A 1 420 ? 15.584 -34.320 4.621   1.00 23.13 ? 447 GLU A CA  1 
ATOM   3290 C C   . GLU A 1 420 ? 16.366 -35.140 5.641   1.00 22.69 ? 447 GLU A C   1 
ATOM   3291 O O   . GLU A 1 420 ? 17.509 -34.823 5.943   1.00 21.75 ? 447 GLU A O   1 
ATOM   3292 C CB  . GLU A 1 420 ? 16.302 -34.332 3.271   1.00 25.53 ? 447 GLU A CB  1 
ATOM   3293 C CG  . GLU A 1 420 ? 16.289 -35.693 2.579   1.00 27.65 ? 447 GLU A CG  1 
ATOM   3294 C CD  . GLU A 1 420 ? 16.912 -35.690 1.194   1.00 29.29 ? 447 GLU A CD  1 
ATOM   3295 O OE1 . GLU A 1 420 ? 16.373 -34.939 0.350   1.00 30.50 ? 447 GLU A OE1 1 
ATOM   3296 O OE2 . GLU A 1 420 ? 17.934 -36.388 0.967   1.00 28.51 ? 447 GLU A OE2 1 
ATOM   3297 N N   . ARG A 1 421 ? 15.745 -36.204 6.144   1.00 23.60 ? 448 ARG A N   1 
ATOM   3298 C CA  . ARG A 1 421 ? 16.281 -37.010 7.227   1.00 26.03 ? 448 ARG A CA  1 
ATOM   3299 C C   . ARG A 1 421 ? 15.760 -38.446 7.081   1.00 28.56 ? 448 ARG A C   1 
ATOM   3300 O O   . ARG A 1 421 ? 14.944 -38.921 7.859   1.00 27.50 ? 448 ARG A O   1 
ATOM   3301 C CB  . ARG A 1 421 ? 15.939 -36.332 8.558   1.00 27.54 ? 448 ARG A CB  1 
ATOM   3302 C CG  . ARG A 1 421 ? 16.284 -37.052 9.863   1.00 34.40 ? 448 ARG A CG  1 
ATOM   3303 C CD  . ARG A 1 421 ? 17.701 -37.558 9.973   1.00 33.50 ? 448 ARG A CD  1 
ATOM   3304 N NE  . ARG A 1 421 ? 18.261 -37.926 11.277  1.00 33.08 ? 448 ARG A NE  1 
ATOM   3305 C CZ  . ARG A 1 421 ? 18.972 -39.025 11.550  1.00 35.66 ? 448 ARG A CZ  1 
ATOM   3306 N NH1 . ARG A 1 421 ? 19.859 -38.988 12.528  1.00 33.94 ? 448 ARG A NH1 1 
ATOM   3307 N NH2 . ARG A 1 421 ? 18.912 -40.100 10.778  1.00 38.40 ? 448 ARG A NH2 1 
ATOM   3308 N N   . PRO A 1 422 ? 16.243 -39.215 6.084   1.00 29.09 ? 449 PRO A N   1 
ATOM   3309 C CA  . PRO A 1 422 ? 15.983 -40.653 6.063   1.00 26.76 ? 449 PRO A CA  1 
ATOM   3310 C C   . PRO A 1 422 ? 16.590 -41.315 7.290   1.00 26.62 ? 449 PRO A C   1 
ATOM   3311 O O   . PRO A 1 422 ? 17.355 -40.711 8.029   1.00 26.07 ? 449 PRO A O   1 
ATOM   3312 C CB  . PRO A 1 422 ? 16.666 -41.127 4.795   1.00 26.41 ? 449 PRO A CB  1 
ATOM   3313 C CG  . PRO A 1 422 ? 17.786 -40.121 4.599   1.00 27.02 ? 449 PRO A CG  1 
ATOM   3314 C CD  . PRO A 1 422 ? 17.179 -38.786 5.031   1.00 27.53 ? 449 PRO A CD  1 
ATOM   3315 N N   . LYS A 1 423 ? 16.268 -42.598 7.446   1.00 29.68 ? 450 LYS A N   1 
ATOM   3316 C CA  . LYS A 1 423 ? 16.814 -43.442 8.488   1.00 29.07 ? 450 LYS A CA  1 
ATOM   3317 C C   . LYS A 1 423 ? 17.910 -44.290 7.856   1.00 24.64 ? 450 LYS A C   1 
ATOM   3318 O O   . LYS A 1 423 ? 17.722 -44.855 6.788   1.00 25.94 ? 450 LYS A O   1 
ATOM   3319 C CB  . LYS A 1 423 ? 15.691 -44.345 9.017   1.00 36.79 ? 450 LYS A CB  1 
ATOM   3320 C CG  . LYS A 1 423 ? 16.120 -45.436 9.992   1.00 40.57 ? 450 LYS A CG  1 
ATOM   3321 C CD  . LYS A 1 423 ? 17.010 -44.898 11.107  1.00 46.39 ? 450 LYS A CD  1 
ATOM   3322 C CE  . LYS A 1 423 ? 17.205 -45.805 12.281  1.00 45.19 ? 450 LYS A CE  1 
ATOM   3323 N NZ  . LYS A 1 423 ? 16.106 -45.570 13.211  1.00 44.94 ? 450 LYS A NZ  1 
ATOM   3324 N N   . SER A 1 424 ? 19.060 -44.376 8.505   1.00 21.95 ? 451 SER A N   1 
ATOM   3325 C CA  . SER A 1 424 ? 20.103 -45.261 8.023   1.00 22.39 ? 451 SER A CA  1 
ATOM   3326 C C   . SER A 1 424 ? 20.051 -46.549 8.841   1.00 23.60 ? 451 SER A C   1 
ATOM   3327 O O   . SER A 1 424 ? 19.401 -46.595 9.878   1.00 25.94 ? 451 SER A O   1 
ATOM   3328 C CB  . SER A 1 424 ? 21.464 -44.612 8.088   1.00 19.71 ? 451 SER A CB  1 
ATOM   3329 O OG  . SER A 1 424 ? 21.913 -44.529 9.429   1.00 19.45 ? 451 SER A OG  1 
ATOM   3330 N N   . MET A 1 425 ? 20.741 -47.582 8.364   1.00 24.78 ? 452 MET A N   1 
ATOM   3331 C CA  . MET A 1 425 ? 20.921 -48.815 9.108   1.00 25.63 ? 452 MET A CA  1 
ATOM   3332 C C   . MET A 1 425 ? 22.330 -49.317 8.857   1.00 25.68 ? 452 MET A C   1 
ATOM   3333 O O   . MET A 1 425 ? 22.863 -49.070 7.783   1.00 23.96 ? 452 MET A O   1 
ATOM   3334 C CB  . MET A 1 425 ? 20.025 -49.941 8.581   1.00 29.86 ? 452 MET A CB  1 
ATOM   3335 C CG  . MET A 1 425 ? 18.579 -49.610 8.512   1.00 32.60 ? 452 MET A CG  1 
ATOM   3336 S SD  . MET A 1 425 ? 17.970 -49.666 10.197  1.00 43.02 ? 452 MET A SD  1 
ATOM   3337 C CE  . MET A 1 425 ? 17.592 -51.419 10.403  1.00 36.94 ? 452 MET A CE  1 
ATOM   3338 N N   . SER A 1 426 ? 22.896 -50.057 9.806   1.00 24.49 ? 453 SER A N   1 
ATOM   3339 C CA  . SER A 1 426 ? 24.116 -50.811 9.540   1.00 26.41 ? 453 SER A CA  1 
ATOM   3340 C C   . SER A 1 426 ? 23.794 -52.125 8.839   1.00 26.96 ? 453 SER A C   1 
ATOM   3341 O O   . SER A 1 426 ? 22.635 -52.541 8.780   1.00 25.99 ? 453 SER A O   1 
ATOM   3342 C CB  . SER A 1 426 ? 24.878 -51.083 10.789  1.00 27.33 ? 453 SER A CB  1 
ATOM   3343 O OG  . SER A 1 426 ? 24.082 -51.825 11.699  1.00 28.35 ? 453 SER A OG  1 
ATOM   3344 N N   . THR A 1 427 ? 24.840 -52.791 8.334   1.00 27.06 ? 454 THR A N   1 
ATOM   3345 C CA  . THR A 1 427 ? 24.698 -54.152 7.832   1.00 28.15 ? 454 THR A CA  1 
ATOM   3346 C C   . THR A 1 427 ? 24.153 -55.046 8.947   1.00 29.78 ? 454 THR A C   1 
ATOM   3347 O O   . THR A 1 427 ? 23.184 -55.775 8.757   1.00 32.47 ? 454 THR A O   1 
ATOM   3348 C CB  . THR A 1 427 ? 26.040 -54.677 7.319   1.00 29.71 ? 454 THR A CB  1 
ATOM   3349 O OG1 . THR A 1 427 ? 26.348 -53.916 6.158   1.00 28.01 ? 454 THR A OG1 1 
ATOM   3350 C CG2 . THR A 1 427 ? 25.996 -56.142 6.910   1.00 28.03 ? 454 THR A CG2 1 
ATOM   3351 N N   . GLU A 1 428 ? 24.814 -55.003 10.104  1.00 28.73 ? 455 GLU A N   1 
ATOM   3352 C CA  . GLU A 1 428 ? 24.439 -55.809 11.249  1.00 32.67 ? 455 GLU A CA  1 
ATOM   3353 C C   . GLU A 1 428 ? 22.981 -55.538 11.611  1.00 32.43 ? 455 GLU A C   1 
ATOM   3354 O O   . GLU A 1 428 ? 22.193 -56.467 11.783  1.00 26.20 ? 455 GLU A O   1 
ATOM   3355 C CB  . GLU A 1 428 ? 25.418 -55.461 12.368  1.00 40.91 ? 455 GLU A CB  1 
ATOM   3356 C CG  . GLU A 1 428 ? 24.966 -55.954 13.739  1.00 49.47 ? 455 GLU A CG  1 
ATOM   3357 C CD  . GLU A 1 428 ? 25.860 -55.586 14.912  1.00 59.90 ? 455 GLU A CD  1 
ATOM   3358 O OE1 . GLU A 1 428 ? 26.945 -54.981 14.720  1.00 60.87 ? 455 GLU A OE1 1 
ATOM   3359 O OE2 . GLU A 1 428 ? 25.437 -55.925 16.040  1.00 63.50 ? 455 GLU A OE2 1 
ATOM   3360 N N   . GLY A 1 429 ? 22.617 -54.251 11.706  1.00 31.07 ? 456 GLY A N   1 
ATOM   3361 C CA  . GLY A 1 429 ? 21.254 -53.865 12.041  1.00 29.61 ? 456 GLY A CA  1 
ATOM   3362 C C   . GLY A 1 429 ? 20.252 -54.324 10.987  1.00 28.77 ? 456 GLY A C   1 
ATOM   3363 O O   . GLY A 1 429 ? 19.167 -54.788 11.319  1.00 29.49 ? 456 GLY A O   1 
ATOM   3364 N N   . LEU A 1 430 ? 20.631 -54.220 9.710   1.00 28.05 ? 457 LEU A N   1 
ATOM   3365 C CA  . LEU A 1 430 ? 19.733 -54.554 8.617   1.00 27.26 ? 457 LEU A CA  1 
ATOM   3366 C C   . LEU A 1 430 ? 19.530 -56.066 8.525   1.00 28.07 ? 457 LEU A C   1 
ATOM   3367 O O   . LEU A 1 430 ? 18.468 -56.516 8.099   1.00 28.09 ? 457 LEU A O   1 
ATOM   3368 C CB  . LEU A 1 430 ? 20.353 -53.952 7.364   1.00 26.35 ? 457 LEU A CB  1 
ATOM   3369 C CG  . LEU A 1 430 ? 19.540 -53.991 6.077   1.00 27.90 ? 457 LEU A CG  1 
ATOM   3370 C CD1 . LEU A 1 430 ? 18.128 -53.456 6.257   1.00 26.40 ? 457 LEU A CD1 1 
ATOM   3371 C CD2 . LEU A 1 430 ? 20.292 -53.173 5.043   1.00 29.95 ? 457 LEU A CD2 1 
ATOM   3372 N N   . MET A 1 431 ? 20.546 -56.837 8.931   1.00 27.66 ? 458 MET A N   1 
ATOM   3373 C CA  . MET A 1 431 ? 20.449 -58.289 8.979   1.00 30.43 ? 458 MET A CA  1 
ATOM   3374 C C   . MET A 1 431 ? 19.474 -58.711 10.076  1.00 30.17 ? 458 MET A C   1 
ATOM   3375 O O   . MET A 1 431 ? 18.632 -59.577 9.833   1.00 30.20 ? 458 MET A O   1 
ATOM   3376 C CB  . MET A 1 431 ? 21.816 -58.956 9.197   1.00 32.02 ? 458 MET A CB  1 
ATOM   3377 C CG  . MET A 1 431 ? 22.809 -58.831 8.022   1.00 34.57 ? 458 MET A CG  1 
ATOM   3378 S SD  . MET A 1 431 ? 24.470 -59.460 8.391   1.00 41.38 ? 458 MET A SD  1 
ATOM   3379 C CE  . MET A 1 431 ? 24.258 -61.238 8.196   1.00 47.48 ? 458 MET A CE  1 
ATOM   3380 N N   . LYS A 1 432 ? 19.596 -58.134 11.284  1.00 32.09 ? 459 LYS A N   1 
ATOM   3381 C CA  . LYS A 1 432 ? 18.675 -58.463 12.364  1.00 35.81 ? 459 LYS A CA  1 
ATOM   3382 C C   . LYS A 1 432 ? 17.260 -58.008 12.002  1.00 39.15 ? 459 LYS A C   1 
ATOM   3383 O O   . LYS A 1 432 ? 16.285 -58.706 12.288  1.00 39.71 ? 459 LYS A O   1 
ATOM   3384 C CB  . LYS A 1 432 ? 18.966 -57.797 13.712  1.00 42.84 ? 459 LYS A CB  1 
ATOM   3385 C CG  . LYS A 1 432 ? 20.317 -58.060 14.348  1.00 50.10 ? 459 LYS A CG  1 
ATOM   3386 C CD  . LYS A 1 432 ? 20.497 -57.251 15.635  1.00 56.09 ? 459 LYS A CD  1 
ATOM   3387 C CE  . LYS A 1 432 ? 21.896 -56.772 15.904  1.00 56.74 ? 459 LYS A CE  1 
ATOM   3388 N NZ  . LYS A 1 432 ? 22.861 -57.870 15.983  1.00 60.50 ? 459 LYS A NZ  1 
ATOM   3389 N N   . PHE A 1 433 ? 17.142 -56.834 11.370  1.00 33.35 ? 460 PHE A N   1 
ATOM   3390 C CA  . PHE A 1 433 ? 15.835 -56.332 10.984  1.00 33.78 ? 460 PHE A CA  1 
ATOM   3391 C C   . PHE A 1 433 ? 15.167 -57.350 10.082  1.00 35.79 ? 460 PHE A C   1 
ATOM   3392 O O   . PHE A 1 433 ? 14.010 -57.682 10.276  1.00 34.62 ? 460 PHE A O   1 
ATOM   3393 C CB  . PHE A 1 433 ? 15.881 -55.015 10.212  1.00 35.52 ? 460 PHE A CB  1 
ATOM   3394 C CG  . PHE A 1 433 ? 14.514 -54.435 9.886   1.00 31.89 ? 460 PHE A CG  1 
ATOM   3395 C CD1 . PHE A 1 433 ? 13.734 -53.858 10.883  1.00 30.27 ? 460 PHE A CD1 1 
ATOM   3396 C CD2 . PHE A 1 433 ? 14.040 -54.425 8.575   1.00 32.85 ? 460 PHE A CD2 1 
ATOM   3397 C CE1 . PHE A 1 433 ? 12.488 -53.322 10.590  1.00 32.57 ? 460 PHE A CE1 1 
ATOM   3398 C CE2 . PHE A 1 433 ? 12.802 -53.866 8.283   1.00 36.12 ? 460 PHE A CE2 1 
ATOM   3399 C CZ  . PHE A 1 433 ? 12.026 -53.319 9.290   1.00 34.51 ? 460 PHE A CZ  1 
ATOM   3400 N N   . VAL A 1 434 ? 15.914 -57.823 9.076   1.00 36.49 ? 461 VAL A N   1 
ATOM   3401 C CA  . VAL A 1 434 ? 15.374 -58.763 8.113   1.00 37.29 ? 461 VAL A CA  1 
ATOM   3402 C C   . VAL A 1 434 ? 15.021 -60.079 8.813   1.00 38.19 ? 461 VAL A C   1 
ATOM   3403 O O   . VAL A 1 434 ? 13.984 -60.655 8.536   1.00 34.00 ? 461 VAL A O   1 
ATOM   3404 C CB  . VAL A 1 434 ? 16.343 -58.977 6.937   1.00 35.76 ? 461 VAL A CB  1 
ATOM   3405 C CG1 . VAL A 1 434 ? 16.088 -60.295 6.226   1.00 34.80 ? 461 VAL A CG1 1 
ATOM   3406 C CG2 . VAL A 1 434 ? 16.272 -57.815 5.961   1.00 36.72 ? 461 VAL A CG2 1 
ATOM   3407 N N   . ASP A 1 435 ? 15.876 -60.530 9.731   1.00 43.07 ? 462 ASP A N   1 
ATOM   3408 C CA  . ASP A 1 435 ? 15.666 -61.768 10.472  1.00 49.09 ? 462 ASP A CA  1 
ATOM   3409 C C   . ASP A 1 435 ? 14.484 -61.676 11.439  1.00 54.21 ? 462 ASP A C   1 
ATOM   3410 O O   . ASP A 1 435 ? 14.092 -62.694 11.994  1.00 61.22 ? 462 ASP A O   1 
ATOM   3411 C CB  . ASP A 1 435 ? 16.940 -62.205 11.181  1.00 44.27 ? 462 ASP A CB  1 
ATOM   3412 C CG  . ASP A 1 435 ? 18.021 -62.746 10.254  1.00 43.87 ? 462 ASP A CG  1 
ATOM   3413 O OD1 . ASP A 1 435 ? 17.726 -62.908 9.038   1.00 44.50 ? 462 ASP A OD1 1 
ATOM   3414 O OD2 . ASP A 1 435 ? 19.150 -62.993 10.744  1.00 40.88 ? 462 ASP A OD2 1 
ATOM   3415 N N   . SER A 1 436 ? 13.909 -60.485 11.641  1.00 55.45 ? 463 SER A N   1 
ATOM   3416 C CA  . SER A 1 436 ? 12.598 -60.387 12.273  1.00 58.29 ? 463 SER A CA  1 
ATOM   3417 C C   . SER A 1 436 ? 11.690 -59.444 11.468  1.00 55.95 ? 463 SER A C   1 
ATOM   3418 O O   . SER A 1 436 ? 10.985 -59.961 10.577  1.00 56.65 ? 463 SER A O   1 
ATOM   3419 C CB  . SER A 1 436 ? 12.708 -59.951 13.716  1.00 57.37 ? 463 SER A CB  1 
ATOM   3420 O OG  . SER A 1 436 ? 13.456 -58.750 13.823  1.00 52.76 ? 463 SER A OG  1 
HETATM 3421 O O1  . OAA B 2 .   ? 21.325 -37.340 -14.185 1.00 42.31 ? 501 OAA A O1  1 
HETATM 3422 O O2  . OAA B 2 .   ? 22.282 -38.518 -12.573 1.00 38.94 ? 501 OAA A O2  1 
HETATM 3423 O O4  . OAA B 2 .   ? 22.927 -33.951 -15.673 1.00 27.66 ? 501 OAA A O4  1 
HETATM 3424 O O5  . OAA B 2 .   ? 22.817 -34.387 -13.571 1.00 30.24 ? 501 OAA A O5  1 
HETATM 3425 O O3  . OAA B 2 .   ? 23.535 -36.423 -16.105 1.00 38.56 ? 501 OAA A O3  1 
HETATM 3426 C C1  . OAA B 2 .   ? 22.322 -37.680 -13.504 1.00 39.58 ? 501 OAA A C1  1 
HETATM 3427 C C2  . OAA B 2 .   ? 23.642 -36.986 -13.810 1.00 36.58 ? 501 OAA A C2  1 
HETATM 3428 C C3  . OAA B 2 .   ? 23.436 -35.999 -14.952 1.00 37.92 ? 501 OAA A C3  1 
HETATM 3429 C C4  . OAA B 2 .   ? 23.064 -34.734 -14.730 1.00 33.17 ? 501 OAA A C4  1 
HETATM 3430 C C   . ACY C 3 .   ? 25.703 -36.458 -16.376 1.00 64.35 ? 502 ACY A C   1 
HETATM 3431 O O   . ACY C 3 .   ? 26.584 -35.717 -16.841 1.00 60.35 ? 502 ACY A O   1 
HETATM 3432 O OXT . ACY C 3 .   ? 25.000 -37.272 -17.063 1.00 55.93 ? 502 ACY A OXT 1 
HETATM 3433 C CH3 . ACY C 3 .   ? 25.479 -36.342 -14.873 1.00 62.62 ? 502 ACY A CH3 1 
HETATM 3434 N N1A . COA D 4 .   ? 30.645 -48.788 -21.486 1.00 58.32 ? 503 COA A N1A 1 
HETATM 3435 C C2A . COA D 4 .   ? 30.940 -49.971 -20.929 1.00 54.25 ? 503 COA A C2A 1 
HETATM 3436 N N3A . COA D 4 .   ? 30.310 -50.622 -19.956 1.00 53.09 ? 503 COA A N3A 1 
HETATM 3437 C C4A . COA D 4 .   ? 29.233 -49.933 -19.545 1.00 57.53 ? 503 COA A C4A 1 
HETATM 3438 C C5A . COA D 4 .   ? 28.799 -48.710 -20.012 1.00 59.74 ? 503 COA A C5A 1 
HETATM 3439 C C6A . COA D 4 .   ? 29.561 -48.110 -21.034 1.00 57.54 ? 503 COA A C6A 1 
HETATM 3440 N N6A . COA D 4 .   ? 29.261 -46.938 -21.582 1.00 56.22 ? 503 COA A N6A 1 
HETATM 3441 N N7A . COA D 4 .   ? 27.645 -48.316 -19.341 1.00 58.01 ? 503 COA A N7A 1 
HETATM 3442 C C8A . COA D 4 .   ? 27.426 -49.279 -18.476 1.00 57.88 ? 503 COA A C8A 1 
HETATM 3443 N N9A . COA D 4 .   ? 28.359 -50.288 -18.555 1.00 54.89 ? 503 COA A N9A 1 
HETATM 3444 C C1B . COA D 4 .   ? 28.425 -51.500 -17.759 1.00 55.07 ? 503 COA A C1B 1 
HETATM 3445 C C2B . COA D 4 .   ? 28.566 -51.230 -16.267 1.00 60.89 ? 503 COA A C2B 1 
HETATM 3446 O O2B . COA D 4 .   ? 29.876 -50.890 -15.867 1.00 52.43 ? 503 COA A O2B 1 
HETATM 3447 C C3B . COA D 4 .   ? 28.082 -52.573 -15.724 1.00 63.48 ? 503 COA A C3B 1 
HETATM 3448 O O3B . COA D 4 .   ? 29.084 -53.565 -15.934 1.00 71.05 ? 503 COA A O3B 1 
HETATM 3449 P P3B . COA D 4 .   ? 29.380 -54.582 -14.729 1.00 76.57 ? 503 COA A P3B 1 
HETATM 3450 O O7A . COA D 4 .   ? 29.609 -53.804 -13.426 1.00 60.28 ? 503 COA A O7A 1 
HETATM 3451 O O8A . COA D 4 .   ? 30.622 -55.298 -15.199 1.00 67.22 ? 503 COA A O8A 1 
HETATM 3452 O O9A . COA D 4 .   ? 28.194 -55.530 -14.653 1.00 82.12 ? 503 COA A O9A 1 
HETATM 3453 C C4B . COA D 4 .   ? 26.899 -52.863 -16.635 1.00 58.31 ? 503 COA A C4B 1 
HETATM 3454 O O4B . COA D 4 .   ? 27.207 -52.198 -17.886 1.00 56.74 ? 503 COA A O4B 1 
HETATM 3455 C C5B . COA D 4 .   ? 25.543 -52.426 -16.140 1.00 60.67 ? 503 COA A C5B 1 
HETATM 3456 O O5B . COA D 4 .   ? 25.642 -51.131 -15.496 1.00 60.08 ? 503 COA A O5B 1 
HETATM 3457 P P1A . COA D 4 .   ? 24.410 -50.117 -15.678 1.00 55.51 ? 503 COA A P1A 1 
HETATM 3458 O O1A . COA D 4 .   ? 23.433 -50.344 -14.572 1.00 58.91 ? 503 COA A O1A 1 
HETATM 3459 O O2A . COA D 4 .   ? 23.942 -50.087 -17.085 1.00 39.25 ? 503 COA A O2A 1 
HETATM 3460 O O3A . COA D 4 .   ? 25.137 -48.718 -15.448 1.00 58.03 ? 503 COA A O3A 1 
HETATM 3461 P P2A . COA D 4 .   ? 25.091 -47.801 -14.156 1.00 63.00 ? 503 COA A P2A 1 
HETATM 3462 O O4A . COA D 4 .   ? 23.699 -47.259 -14.072 1.00 74.87 ? 503 COA A O4A 1 
HETATM 3463 O O5A . COA D 4 .   ? 25.694 -48.495 -12.981 1.00 51.18 ? 503 COA A O5A 1 
HETATM 3464 O O6A . COA D 4 .   ? 26.132 -46.660 -14.583 1.00 56.99 ? 503 COA A O6A 1 
HETATM 3465 C CBP . COA D 4 .   ? 27.003 -45.026 -16.074 1.00 46.42 ? 503 COA A CBP 1 
HETATM 3466 C CCP . COA D 4 .   ? 25.724 -45.649 -15.537 1.00 47.75 ? 503 COA A CCP 1 
HETATM 3467 C CDP . COA D 4 .   ? 26.679 -43.745 -16.855 1.00 42.63 ? 503 COA A CDP 1 
HETATM 3468 C CEP . COA D 4 .   ? 27.905 -44.689 -14.880 1.00 47.10 ? 503 COA A CEP 1 
HETATM 3469 C CAP . COA D 4 .   ? 27.698 -46.041 -16.987 1.00 41.16 ? 503 COA A CAP 1 
HETATM 3470 O OAP . COA D 4 .   ? 26.929 -46.250 -18.154 1.00 38.89 ? 503 COA A OAP 1 
HETATM 3471 C C9P . COA D 4 .   ? 29.082 -45.557 -17.372 1.00 39.52 ? 503 COA A C9P 1 
HETATM 3472 O O9P . COA D 4 .   ? 30.041 -45.879 -16.671 1.00 39.56 ? 503 COA A O9P 1 
HETATM 3473 N N8P . COA D 4 .   ? 29.177 -44.824 -18.475 1.00 36.78 ? 503 COA A N8P 1 
HETATM 3474 C C7P . COA D 4 .   ? 30.412 -44.165 -18.887 1.00 38.20 ? 503 COA A C7P 1 
HETATM 3475 C C6P . COA D 4 .   ? 30.675 -42.900 -18.075 1.00 36.99 ? 503 COA A C6P 1 
HETATM 3476 C C5P . COA D 4 .   ? 29.694 -41.792 -18.418 1.00 34.08 ? 503 COA A C5P 1 
HETATM 3477 O O5P . COA D 4 .   ? 29.443 -41.524 -19.600 1.00 29.85 ? 503 COA A O5P 1 
HETATM 3478 N N4P . COA D 4 .   ? 29.144 -41.141 -17.376 1.00 31.88 ? 503 COA A N4P 1 
HETATM 3479 C C3P . COA D 4 .   ? 28.383 -39.900 -17.471 1.00 43.35 ? 503 COA A C3P 1 
HETATM 3480 C C2P . COA D 4 .   ? 26.918 -40.038 -17.031 1.00 52.60 ? 503 COA A C2P 1 
HETATM 3481 S S1P . COA D 4 .   ? 26.646 -39.929 -15.237 1.00 58.54 ? 503 COA A S1P 1 
HETATM 3482 O O   . HOH E 5 .   ? 29.623 -35.575 -15.885 1.00 34.16 ? 601 HOH A O   1 
HETATM 3483 O O   . HOH E 5 .   ? 14.893 -11.523 -28.938 1.00 41.56 ? 602 HOH A O   1 
HETATM 3484 O O   . HOH E 5 .   ? 17.217 -31.167 -30.218 1.00 35.96 ? 603 HOH A O   1 
HETATM 3485 O O   . HOH E 5 .   ? 40.843 -44.633 -25.719 1.00 40.70 ? 604 HOH A O   1 
HETATM 3486 O O   . HOH E 5 .   ? 20.150 -17.084 -29.392 1.00 35.82 ? 605 HOH A O   1 
HETATM 3487 O O   . HOH E 5 .   ? 18.296 -10.819 -23.137 1.00 29.99 ? 606 HOH A O   1 
HETATM 3488 O O   . HOH E 5 .   ? 2.251  -15.395 -2.403  1.00 50.13 ? 607 HOH A O   1 
HETATM 3489 O O   . HOH E 5 .   ? -2.590 -32.242 3.543   1.00 30.21 ? 608 HOH A O   1 
HETATM 3490 O O   . HOH E 5 .   ? 31.921 -12.882 -26.158 1.00 32.20 ? 609 HOH A O   1 
HETATM 3491 O O   . HOH E 5 .   ? 45.136 -22.667 -21.530 1.00 37.85 ? 610 HOH A O   1 
HETATM 3492 O O   . HOH E 5 .   ? 17.982 -53.822 13.340  1.00 43.87 ? 611 HOH A O   1 
HETATM 3493 O O   . HOH E 5 .   ? 23.221 -46.488 10.370  1.00 23.53 ? 612 HOH A O   1 
HETATM 3494 O O   . HOH E 5 .   ? 13.427 -27.226 5.627   1.00 18.49 ? 613 HOH A O   1 
HETATM 3495 O O   . HOH E 5 .   ? -3.436 -22.107 -0.920  1.00 41.60 ? 614 HOH A O   1 
HETATM 3496 O O   . HOH E 5 .   ? 21.172 -27.529 -31.627 1.00 37.67 ? 615 HOH A O   1 
HETATM 3497 O O   . HOH E 5 .   ? 44.123 -25.654 -11.227 1.00 30.92 ? 616 HOH A O   1 
HETATM 3498 O O   . HOH E 5 .   ? 22.129 -15.760 -21.988 1.00 27.95 ? 617 HOH A O   1 
HETATM 3499 O O   . HOH E 5 .   ? 8.131  -30.622 -13.787 1.00 29.86 ? 618 HOH A O   1 
HETATM 3500 O O   . HOH E 5 .   ? 28.369 -41.788 -12.870 1.00 32.14 ? 619 HOH A O   1 
HETATM 3501 O O   . HOH E 5 .   ? 14.174 -33.045 -24.254 1.00 30.74 ? 620 HOH A O   1 
HETATM 3502 O O   . HOH E 5 .   ? 32.975 -34.569 -24.103 1.00 32.99 ? 621 HOH A O   1 
HETATM 3503 O O   . HOH E 5 .   ? 21.593 -41.610 -23.058 1.00 38.32 ? 622 HOH A O   1 
HETATM 3504 O O   . HOH E 5 .   ? 25.270 -51.827 14.015  1.00 36.41 ? 623 HOH A O   1 
HETATM 3505 O O   . HOH E 5 .   ? 22.528 -12.108 -2.135  1.00 26.25 ? 624 HOH A O   1 
HETATM 3506 O O   . HOH E 5 .   ? 19.605 0.189   -21.853 1.00 46.95 ? 625 HOH A O   1 
HETATM 3507 O O   . HOH E 5 .   ? 13.875 -34.229 0.628   1.00 21.46 ? 626 HOH A O   1 
HETATM 3508 O O   . HOH E 5 .   ? 31.280 -21.971 -35.746 1.00 35.21 ? 627 HOH A O   1 
HETATM 3509 O O   . HOH E 5 .   ? 41.974 -17.652 -9.249  1.00 23.73 ? 628 HOH A O   1 
HETATM 3510 O O   . HOH E 5 .   ? 20.961 -4.332  -16.128 1.00 38.32 ? 629 HOH A O   1 
HETATM 3511 O O   . HOH E 5 .   ? 29.497 -50.793 -35.568 1.00 51.52 ? 630 HOH A O   1 
HETATM 3512 O O   . HOH E 5 .   ? 28.514 -32.123 -20.712 1.00 25.69 ? 631 HOH A O   1 
HETATM 3513 O O   . HOH E 5 .   ? 16.731 -60.147 14.446  1.00 41.37 ? 632 HOH A O   1 
HETATM 3514 O O   . HOH E 5 .   ? 2.307  -29.158 -9.530  1.00 33.55 ? 633 HOH A O   1 
HETATM 3515 O O   . HOH E 5 .   ? 47.402 -16.624 -7.077  1.00 43.13 ? 634 HOH A O   1 
HETATM 3516 O O   . HOH E 5 .   ? 29.456 -39.728 -30.091 1.00 31.22 ? 635 HOH A O   1 
HETATM 3517 O O   . HOH E 5 .   ? 20.623 -7.356  -20.553 1.00 43.15 ? 636 HOH A O   1 
HETATM 3518 O O   . HOH E 5 .   ? 22.448 -10.305 -18.572 1.00 32.69 ? 637 HOH A O   1 
HETATM 3519 O O   . HOH E 5 .   ? 15.207 -5.570  -14.434 1.00 39.99 ? 638 HOH A O   1 
HETATM 3520 O O   . HOH E 5 .   ? 8.459  -16.047 -26.030 1.00 40.54 ? 639 HOH A O   1 
HETATM 3521 O O   . HOH E 5 .   ? 3.266  -25.568 1.223   1.00 41.63 ? 640 HOH A O   1 
HETATM 3522 O O   . HOH E 5 .   ? 5.923  -9.592  -21.051 1.00 41.66 ? 641 HOH A O   1 
HETATM 3523 O O   . HOH E 5 .   ? 6.714  -19.135 10.606  1.00 42.81 ? 642 HOH A O   1 
HETATM 3524 O O   . HOH E 5 .   ? 15.747 -27.874 -0.382  1.00 17.89 ? 643 HOH A O   1 
HETATM 3525 O O   . HOH E 5 .   ? 35.478 -11.136 -24.684 1.00 40.22 ? 644 HOH A O   1 
HETATM 3526 O O   . HOH E 5 .   ? 30.824 -33.557 -17.667 1.00 27.67 ? 645 HOH A O   1 
HETATM 3527 O O   . HOH E 5 .   ? 13.367 -15.078 -29.537 1.00 38.49 ? 646 HOH A O   1 
HETATM 3528 O O   . HOH E 5 .   ? 39.054 -41.127 -20.062 1.00 29.95 ? 647 HOH A O   1 
HETATM 3529 O O   . HOH E 5 .   ? 27.040 -37.073 -32.972 1.00 37.26 ? 648 HOH A O   1 
HETATM 3530 O O   . HOH E 5 .   ? 13.732 -17.293 11.672  1.00 45.21 ? 649 HOH A O   1 
HETATM 3531 O O   . HOH E 5 .   ? 0.669  -46.142 4.236   1.00 38.98 ? 650 HOH A O   1 
HETATM 3532 O O   . HOH E 5 .   ? 25.545 -5.790  -8.410  1.00 43.43 ? 651 HOH A O   1 
HETATM 3533 O O   . HOH E 5 .   ? 11.033 -24.645 4.000   1.00 23.02 ? 652 HOH A O   1 
HETATM 3534 O O   . HOH E 5 .   ? 9.162  -31.856 -16.419 1.00 36.83 ? 653 HOH A O   1 
HETATM 3535 O O   . HOH E 5 .   ? 32.097 -40.133 -14.971 1.00 33.94 ? 654 HOH A O   1 
HETATM 3536 O O   . HOH E 5 .   ? -4.627 -31.573 -5.480  1.00 27.44 ? 655 HOH A O   1 
HETATM 3537 O O   . HOH E 5 .   ? 17.648 -27.433 -4.968  1.00 19.73 ? 656 HOH A O   1 
HETATM 3538 O O   . HOH E 5 .   ? 36.755 -29.334 -6.591  1.00 27.15 ? 657 HOH A O   1 
HETATM 3539 O O   . HOH E 5 .   ? 20.621 -31.124 -17.620 1.00 25.09 ? 658 HOH A O   1 
HETATM 3540 O O   . HOH E 5 .   ? 32.942 -41.479 -26.352 1.00 33.33 ? 659 HOH A O   1 
HETATM 3541 O O   . HOH E 5 .   ? 28.991 -15.055 6.134   1.00 27.30 ? 660 HOH A O   1 
HETATM 3542 O O   . HOH E 5 .   ? 23.528 -58.701 12.627  1.00 42.19 ? 661 HOH A O   1 
HETATM 3543 O O   . HOH E 5 .   ? 10.203 -46.127 -5.392  1.00 39.74 ? 662 HOH A O   1 
HETATM 3544 O O   . HOH E 5 .   ? 47.972 -17.814 -1.736  1.00 31.75 ? 663 HOH A O   1 
HETATM 3545 O O   . HOH E 5 .   ? 12.107 -29.634 8.905   1.00 30.19 ? 664 HOH A O   1 
HETATM 3546 O O   . HOH E 5 .   ? 14.933 -17.900 -23.446 1.00 26.15 ? 665 HOH A O   1 
HETATM 3547 O O   . HOH E 5 .   ? 27.038 -51.277 -2.394  1.00 34.19 ? 666 HOH A O   1 
HETATM 3548 O O   . HOH E 5 .   ? 24.847 -10.793 -17.544 1.00 30.14 ? 667 HOH A O   1 
HETATM 3549 O O   . HOH E 5 .   ? 23.360 -9.238  -1.220  1.00 32.47 ? 668 HOH A O   1 
HETATM 3550 O O   . HOH E 5 .   ? 32.813 -34.740 -26.831 1.00 25.42 ? 669 HOH A O   1 
HETATM 3551 O O   . HOH E 5 .   ? 38.467 -6.013  -15.306 1.00 45.21 ? 670 HOH A O   1 
HETATM 3552 O O   . HOH E 5 .   ? 42.866 -16.979 -1.466  1.00 21.46 ? 671 HOH A O   1 
HETATM 3553 O O   . HOH E 5 .   ? 30.851 -3.377  -15.692 1.00 54.49 ? 672 HOH A O   1 
HETATM 3554 O O   . HOH E 5 .   ? -1.122 -47.562 -0.851  1.00 31.81 ? 673 HOH A O   1 
HETATM 3555 O O   . HOH E 5 .   ? 17.172 -9.270  7.501   1.00 48.93 ? 674 HOH A O   1 
HETATM 3556 O O   . HOH E 5 .   ? 15.506 -27.812 -3.064  1.00 15.81 ? 675 HOH A O   1 
HETATM 3557 O O   . HOH E 5 .   ? 3.911  -21.515 -21.444 1.00 38.14 ? 676 HOH A O   1 
HETATM 3558 O O   . HOH E 5 .   ? 24.317 -41.457 -15.411 1.00 44.37 ? 677 HOH A O   1 
HETATM 3559 O O   . HOH E 5 .   ? 20.363 -19.623 6.836   1.00 25.94 ? 678 HOH A O   1 
HETATM 3560 O O   . HOH E 5 .   ? 22.610 -20.078 5.699   1.00 22.45 ? 679 HOH A O   1 
HETATM 3561 O O   . HOH E 5 .   ? 8.764  -8.858  -28.311 1.00 37.28 ? 680 HOH A O   1 
HETATM 3562 O O   . HOH E 5 .   ? 28.833 -6.784  -1.831  1.00 32.48 ? 681 HOH A O   1 
HETATM 3563 O O   . HOH E 5 .   ? 31.304 -8.083  1.862   1.00 41.23 ? 682 HOH A O   1 
HETATM 3564 O O   . HOH E 5 .   ? 39.299 -12.720 1.289   1.00 30.03 ? 683 HOH A O   1 
HETATM 3565 O O   . HOH E 5 .   ? 11.256 -33.366 -1.798  1.00 22.85 ? 684 HOH A O   1 
HETATM 3566 O O   . HOH E 5 .   ? 2.356  -22.680 -13.573 1.00 42.89 ? 685 HOH A O   1 
HETATM 3567 O O   . HOH E 5 .   ? 17.094 -8.432  3.015   1.00 39.28 ? 686 HOH A O   1 
HETATM 3568 O O   . HOH E 5 .   ? -6.773 -28.535 -4.007  1.00 41.45 ? 687 HOH A O   1 
HETATM 3569 O O   . HOH E 5 .   ? 39.379 -7.075  -3.919  1.00 50.49 ? 688 HOH A O   1 
HETATM 3570 O O   . HOH E 5 .   ? 21.557 -45.749 -0.283  1.00 22.02 ? 689 HOH A O   1 
HETATM 3571 O O   . HOH E 5 .   ? 44.358 -19.163 -9.521  1.00 29.16 ? 690 HOH A O   1 
HETATM 3572 O O   . HOH E 5 .   ? 12.840 -31.860 1.717   1.00 20.65 ? 691 HOH A O   1 
HETATM 3573 O O   . HOH E 5 .   ? 34.325 -28.296 -5.841  1.00 24.37 ? 692 HOH A O   1 
HETATM 3574 O O   . HOH E 5 .   ? 13.627 -29.332 0.701   1.00 24.55 ? 693 HOH A O   1 
HETATM 3575 O O   . HOH E 5 .   ? -3.778 -41.200 2.111   1.00 41.89 ? 694 HOH A O   1 
HETATM 3576 O O   . HOH E 5 .   ? 17.784 -44.626 -28.108 1.00 43.45 ? 695 HOH A O   1 
HETATM 3577 O O   . HOH E 5 .   ? 12.262 -7.288  -25.355 1.00 42.03 ? 696 HOH A O   1 
HETATM 3578 O O   . HOH E 5 .   ? 36.813 -30.137 -31.828 1.00 37.04 ? 697 HOH A O   1 
HETATM 3579 O O   . HOH E 5 .   ? 42.748 -28.102 -17.900 1.00 40.66 ? 698 HOH A O   1 
HETATM 3580 O O   . HOH E 5 .   ? 8.358  -19.374 2.100   1.00 20.90 ? 699 HOH A O   1 
HETATM 3581 O O   . HOH E 5 .   ? 5.918  -29.194 -12.440 1.00 33.83 ? 700 HOH A O   1 
HETATM 3582 O O   . HOH E 5 .   ? 34.198 -7.604  0.859   1.00 27.65 ? 701 HOH A O   1 
HETATM 3583 O O   . HOH E 5 .   ? -2.594 -46.570 1.739   1.00 44.22 ? 702 HOH A O   1 
HETATM 3584 O O   . HOH E 5 .   ? 24.050 -38.012 -10.191 1.00 26.10 ? 703 HOH A O   1 
HETATM 3585 O O   . HOH E 5 .   ? 12.607 -10.601 -0.126  1.00 24.30 ? 704 HOH A O   1 
HETATM 3586 O O   . HOH E 5 .   ? 31.916 -14.668 -34.830 1.00 47.91 ? 705 HOH A O   1 
HETATM 3587 O O   . HOH E 5 .   ? 26.912 -12.774 -17.288 1.00 33.14 ? 706 HOH A O   1 
HETATM 3588 O O   . HOH E 5 .   ? 20.603 -18.147 9.267   1.00 31.10 ? 707 HOH A O   1 
HETATM 3589 O O   . HOH E 5 .   ? 31.983 -31.215 -17.291 1.00 32.77 ? 708 HOH A O   1 
HETATM 3590 O O   . HOH E 5 .   ? 22.515 -45.705 -9.346  1.00 46.23 ? 709 HOH A O   1 
HETATM 3591 O O   . HOH E 5 .   ? 17.704 -36.282 -20.750 1.00 30.88 ? 710 HOH A O   1 
HETATM 3592 O O   . HOH E 5 .   ? 24.678 -47.137 -1.048  1.00 23.34 ? 711 HOH A O   1 
HETATM 3593 O O   . HOH E 5 .   ? 33.086 -24.754 -0.000  0.50 34.10 ? 712 HOH A O   1 
HETATM 3594 O O   . HOH E 5 .   ? 6.274  -25.639 -8.368  1.00 34.46 ? 713 HOH A O   1 
HETATM 3595 O O   . HOH E 5 .   ? 31.457 -40.346 -38.722 1.00 43.20 ? 714 HOH A O   1 
HETATM 3596 O O   . HOH E 5 .   ? 40.052 -32.855 -16.862 1.00 44.65 ? 715 HOH A O   1 
HETATM 3597 O O   . HOH E 5 .   ? 30.793 -48.412 -39.710 1.00 41.52 ? 716 HOH A O   1 
HETATM 3598 O O   . HOH E 5 .   ? 8.305  -12.264 8.861   1.00 47.37 ? 717 HOH A O   1 
HETATM 3599 O O   . HOH E 5 .   ? 21.651 -29.354 -37.925 1.00 39.46 ? 718 HOH A O   1 
HETATM 3600 O O   . HOH E 5 .   ? 17.476 -7.988  -3.282  1.00 33.10 ? 719 HOH A O   1 
HETATM 3601 O O   . HOH E 5 .   ? 31.099 -43.898 -14.618 1.00 39.33 ? 720 HOH A O   1 
HETATM 3602 O O   . HOH E 5 .   ? 43.126 -14.716 -0.001  0.50 29.94 ? 721 HOH A O   1 
HETATM 3603 O O   . HOH E 5 .   ? 38.505 -8.854  -12.651 1.00 35.46 ? 722 HOH A O   1 
HETATM 3604 O O   . HOH E 5 .   ? 36.487 -31.232 -13.220 1.00 41.25 ? 723 HOH A O   1 
HETATM 3605 O O   . HOH E 5 .   ? 4.901  -16.283 -16.863 1.00 35.61 ? 724 HOH A O   1 
HETATM 3606 O O   . HOH E 5 .   ? 32.763 -5.622  -0.835  1.00 28.90 ? 725 HOH A O   1 
HETATM 3607 O O   . HOH E 5 .   ? 50.574 -20.830 -8.167  1.00 33.85 ? 726 HOH A O   1 
HETATM 3608 O O   . HOH E 5 .   ? 2.608  -30.016 2.045   1.00 34.51 ? 727 HOH A O   1 
HETATM 3609 O O   . HOH E 5 .   ? 46.439 -20.316 -21.782 1.00 41.99 ? 728 HOH A O   1 
HETATM 3610 O O   . HOH E 5 .   ? 16.809 -37.975 -28.798 1.00 33.42 ? 729 HOH A O   1 
HETATM 3611 O O   . HOH E 5 .   ? -4.345 -20.529 -3.818  1.00 48.35 ? 730 HOH A O   1 
HETATM 3612 O O   . HOH E 5 .   ? 18.437 -6.905  -21.530 1.00 41.55 ? 731 HOH A O   1 
HETATM 3613 O O   . HOH E 5 .   ? -0.072 -21.551 -13.749 1.00 48.03 ? 732 HOH A O   1 
HETATM 3614 O O   . HOH E 5 .   ? 37.920 -31.118 -8.345  1.00 24.77 ? 733 HOH A O   1 
HETATM 3615 O O   . HOH E 5 .   ? 42.094 -8.522  -12.586 1.00 47.23 ? 734 HOH A O   1 
HETATM 3616 O O   . HOH E 5 .   ? 14.963 -6.689  -2.945  1.00 54.04 ? 735 HOH A O   1 
HETATM 3617 O O   . HOH E 5 .   ? -3.299 -24.019 0.872   1.00 34.78 ? 736 HOH A O   1 
HETATM 3618 O O   . HOH E 5 .   ? 39.576 -37.356 -17.561 1.00 35.74 ? 737 HOH A O   1 
HETATM 3619 O O   . HOH E 5 .   ? 39.104 -40.466 -15.289 1.00 39.67 ? 738 HOH A O   1 
HETATM 3620 O O   . HOH E 5 .   ? 0.111  -31.656 4.109   1.00 42.83 ? 739 HOH A O   1 
HETATM 3621 O O   . HOH E 5 .   ? 3.596  -24.800 -11.755 1.00 48.62 ? 740 HOH A O   1 
HETATM 3622 O O   . HOH E 5 .   ? 4.401  -21.400 7.402   1.00 51.43 ? 741 HOH A O   1 
HETATM 3623 O O   . HOH E 5 .   ? 17.507 -29.866 -36.659 1.00 44.10 ? 742 HOH A O   1 
HETATM 3624 O O   . HOH E 5 .   ? 20.379 -18.339 11.880  1.00 25.21 ? 743 HOH A O   1 
HETATM 3625 O O   . HOH E 5 .   ? 40.640 -42.756 -21.246 1.00 41.99 ? 744 HOH A O   1 
HETATM 3626 O O   . HOH E 5 .   ? 26.999 -12.346 -30.371 1.00 37.49 ? 745 HOH A O   1 
HETATM 3627 O O   . HOH E 5 .   ? -1.056 -21.079 -11.408 1.00 41.68 ? 746 HOH A O   1 
HETATM 3628 O O   . HOH E 5 .   ? 30.455 -45.802 -12.222 1.00 34.07 ? 747 HOH A O   1 
HETATM 3629 O O   . HOH E 5 .   ? 23.563 -18.470 9.486   1.00 33.11 ? 748 HOH A O   1 
HETATM 3630 O O   . HOH E 5 .   ? 40.131 -39.813 -17.909 1.00 46.30 ? 749 HOH A O   1 
HETATM 3631 O O   . HOH E 5 .   ? -4.379 -45.225 4.006   1.00 58.26 ? 750 HOH A O   1 
HETATM 3632 O O   . HOH E 5 .   ? 28.576 -44.279 -11.414 1.00 28.90 ? 751 HOH A O   1 
HETATM 3633 O O   . HOH E 5 .   ? 37.068 -8.108  -10.741 1.00 52.97 ? 752 HOH A O   1 
# 
