data_8ZVQ
# 
_entry.id   8ZVQ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZVQ         pdb_00008zvq 10.2210/pdb8zvq/pdb 
WWPDB D_1300048633 ?            ?                   
EMDB  EMD-60512    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-23 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZVQ 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-11 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM Structure of Human Hormone-sensitive Lipase (HSL)' 
_pdbx_database_related.db_id          EMD-60512 
_pdbx_database_related.content_type   'associated EM volume' 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 wujianping@westlake.edu.cn Jianping Wu ? 'principal investigator/group leader' 0000-0001-9869-7691 
4 huqi@westlake.edu.cn       Qi       Hu ? 'principal investigator/group leader' 0000-0001-7803-7821 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Peng, H.' 1 ? 
'Xu, Q.'   2 ? 
'Wu, J.'   3 ? 
'Hu, Q.'   4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            16 
_citation.language                  ? 
_citation.page_first                3497 
_citation.page_last                 3497 
_citation.title                     
'Molecular determinants for the association of human hormone-sensitive lipase with lipid droplets.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-025-58887-z 
_citation.pdbx_database_id_PubMed   40221426 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Peng, H.'  1 ?                   
primary 'Xu, Q.'    2 ?                   
primary 'Zhang, T.' 3 ?                   
primary 'Zhu, J.'   4 ?                   
primary 'Pan, J.'   5 ?                   
primary 'Guan, X.'  6 ?                   
primary 'Feng, S.'  7 0000-0001-6474-4429 
primary 'Wu, J.'    8 0000-0001-9869-7691 
primary 'Hu, Q.'    9 0000-0001-7803-7821 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'Hormone-sensitive lipase' 
_entity.formula_weight             84218.227 
_entity.pdbx_number_of_molecules   2 
_entity.pdbx_ec                    3.1.1.79,3.1.1.23 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'HSL,Monoacylglycerol lipase LIPE,Retinyl ester hydrolase,REH' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTAR
CCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLH
KGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKA
FWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSS
LIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFA
YCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLS
KCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQ
PQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAF
PEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVED
LPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTAR
CCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLH
KGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKA
FWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSS
LIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFA
YCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLS
KCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQ
PQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAF
PEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVED
LPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   LEU n 
1 4   ARG n 
1 5   THR n 
1 6   MET n 
1 7   THR n 
1 8   GLN n 
1 9   SER n 
1 10  LEU n 
1 11  VAL n 
1 12  THR n 
1 13  LEU n 
1 14  ALA n 
1 15  GLU n 
1 16  ASP n 
1 17  ASN n 
1 18  ILE n 
1 19  ALA n 
1 20  PHE n 
1 21  PHE n 
1 22  SER n 
1 23  SER n 
1 24  GLN n 
1 25  GLY n 
1 26  PRO n 
1 27  GLY n 
1 28  GLU n 
1 29  THR n 
1 30  ALA n 
1 31  GLN n 
1 32  ARG n 
1 33  LEU n 
1 34  SER n 
1 35  GLY n 
1 36  VAL n 
1 37  PHE n 
1 38  ALA n 
1 39  GLY n 
1 40  VAL n 
1 41  ARG n 
1 42  GLU n 
1 43  GLN n 
1 44  ALA n 
1 45  LEU n 
1 46  GLY n 
1 47  LEU n 
1 48  GLU n 
1 49  PRO n 
1 50  ALA n 
1 51  LEU n 
1 52  GLY n 
1 53  ARG n 
1 54  LEU n 
1 55  LEU n 
1 56  GLY n 
1 57  VAL n 
1 58  ALA n 
1 59  HIS n 
1 60  LEU n 
1 61  PHE n 
1 62  ASP n 
1 63  LEU n 
1 64  ASP n 
1 65  PRO n 
1 66  GLU n 
1 67  THR n 
1 68  PRO n 
1 69  ALA n 
1 70  ASN n 
1 71  GLY n 
1 72  TYR n 
1 73  ARG n 
1 74  SER n 
1 75  LEU n 
1 76  VAL n 
1 77  HIS n 
1 78  THR n 
1 79  ALA n 
1 80  ARG n 
1 81  CYS n 
1 82  CYS n 
1 83  LEU n 
1 84  ALA n 
1 85  HIS n 
1 86  LEU n 
1 87  LEU n 
1 88  HIS n 
1 89  LYS n 
1 90  SER n 
1 91  ARG n 
1 92  TYR n 
1 93  VAL n 
1 94  ALA n 
1 95  SER n 
1 96  ASN n 
1 97  ARG n 
1 98  ARG n 
1 99  SER n 
1 100 ILE n 
1 101 PHE n 
1 102 PHE n 
1 103 ARG n 
1 104 THR n 
1 105 SER n 
1 106 HIS n 
1 107 ASN n 
1 108 LEU n 
1 109 ALA n 
1 110 GLU n 
1 111 LEU n 
1 112 GLU n 
1 113 ALA n 
1 114 TYR n 
1 115 LEU n 
1 116 ALA n 
1 117 ALA n 
1 118 LEU n 
1 119 THR n 
1 120 GLN n 
1 121 LEU n 
1 122 ARG n 
1 123 ALA n 
1 124 LEU n 
1 125 VAL n 
1 126 TYR n 
1 127 TYR n 
1 128 ALA n 
1 129 GLN n 
1 130 ARG n 
1 131 LEU n 
1 132 LEU n 
1 133 VAL n 
1 134 THR n 
1 135 ASN n 
1 136 ARG n 
1 137 PRO n 
1 138 GLY n 
1 139 VAL n 
1 140 LEU n 
1 141 PHE n 
1 142 PHE n 
1 143 GLU n 
1 144 GLY n 
1 145 ASP n 
1 146 GLU n 
1 147 GLY n 
1 148 LEU n 
1 149 THR n 
1 150 ALA n 
1 151 ASP n 
1 152 PHE n 
1 153 LEU n 
1 154 ARG n 
1 155 GLU n 
1 156 TYR n 
1 157 VAL n 
1 158 THR n 
1 159 LEU n 
1 160 HIS n 
1 161 LYS n 
1 162 GLY n 
1 163 CYS n 
1 164 PHE n 
1 165 TYR n 
1 166 GLY n 
1 167 ARG n 
1 168 CYS n 
1 169 LEU n 
1 170 GLY n 
1 171 PHE n 
1 172 GLN n 
1 173 PHE n 
1 174 THR n 
1 175 PRO n 
1 176 ALA n 
1 177 ILE n 
1 178 ARG n 
1 179 PRO n 
1 180 PHE n 
1 181 LEU n 
1 182 GLN n 
1 183 THR n 
1 184 ILE n 
1 185 SER n 
1 186 ILE n 
1 187 GLY n 
1 188 LEU n 
1 189 VAL n 
1 190 SER n 
1 191 PHE n 
1 192 GLY n 
1 193 GLU n 
1 194 HIS n 
1 195 TYR n 
1 196 LYS n 
1 197 ARG n 
1 198 ASN n 
1 199 GLU n 
1 200 THR n 
1 201 GLY n 
1 202 LEU n 
1 203 SER n 
1 204 VAL n 
1 205 ALA n 
1 206 ALA n 
1 207 SER n 
1 208 SER n 
1 209 LEU n 
1 210 PHE n 
1 211 THR n 
1 212 SER n 
1 213 GLY n 
1 214 ARG n 
1 215 PHE n 
1 216 ALA n 
1 217 ILE n 
1 218 ASP n 
1 219 PRO n 
1 220 GLU n 
1 221 LEU n 
1 222 ARG n 
1 223 GLY n 
1 224 ALA n 
1 225 GLU n 
1 226 PHE n 
1 227 GLU n 
1 228 ARG n 
1 229 ILE n 
1 230 THR n 
1 231 GLN n 
1 232 ASN n 
1 233 LEU n 
1 234 ASP n 
1 235 VAL n 
1 236 HIS n 
1 237 PHE n 
1 238 TRP n 
1 239 LYS n 
1 240 ALA n 
1 241 PHE n 
1 242 TRP n 
1 243 ASN n 
1 244 ILE n 
1 245 THR n 
1 246 GLU n 
1 247 MET n 
1 248 GLU n 
1 249 VAL n 
1 250 LEU n 
1 251 SER n 
1 252 SER n 
1 253 LEU n 
1 254 ALA n 
1 255 ASN n 
1 256 MET n 
1 257 ALA n 
1 258 SER n 
1 259 ALA n 
1 260 THR n 
1 261 VAL n 
1 262 ARG n 
1 263 VAL n 
1 264 SER n 
1 265 ARG n 
1 266 LEU n 
1 267 LEU n 
1 268 SER n 
1 269 LEU n 
1 270 PRO n 
1 271 PRO n 
1 272 GLU n 
1 273 ALA n 
1 274 PHE n 
1 275 GLU n 
1 276 MET n 
1 277 PRO n 
1 278 LEU n 
1 279 THR n 
1 280 ALA n 
1 281 ASP n 
1 282 PRO n 
1 283 THR n 
1 284 LEU n 
1 285 THR n 
1 286 VAL n 
1 287 THR n 
1 288 ILE n 
1 289 SER n 
1 290 PRO n 
1 291 PRO n 
1 292 LEU n 
1 293 ALA n 
1 294 HIS n 
1 295 THR n 
1 296 GLY n 
1 297 PRO n 
1 298 GLY n 
1 299 PRO n 
1 300 VAL n 
1 301 LEU n 
1 302 VAL n 
1 303 ARG n 
1 304 LEU n 
1 305 ILE n 
1 306 SER n 
1 307 TYR n 
1 308 ASP n 
1 309 LEU n 
1 310 ARG n 
1 311 GLU n 
1 312 GLY n 
1 313 GLN n 
1 314 ASP n 
1 315 SER n 
1 316 GLU n 
1 317 GLU n 
1 318 LEU n 
1 319 SER n 
1 320 SER n 
1 321 LEU n 
1 322 ILE n 
1 323 LYS n 
1 324 SER n 
1 325 ASN n 
1 326 GLY n 
1 327 GLN n 
1 328 ARG n 
1 329 SER n 
1 330 LEU n 
1 331 GLU n 
1 332 LEU n 
1 333 TRP n 
1 334 PRO n 
1 335 ARG n 
1 336 PRO n 
1 337 GLN n 
1 338 GLN n 
1 339 ALA n 
1 340 PRO n 
1 341 ARG n 
1 342 SER n 
1 343 ARG n 
1 344 SER n 
1 345 LEU n 
1 346 ILE n 
1 347 VAL n 
1 348 HIS n 
1 349 PHE n 
1 350 HIS n 
1 351 GLY n 
1 352 GLY n 
1 353 GLY n 
1 354 PHE n 
1 355 VAL n 
1 356 ALA n 
1 357 GLN n 
1 358 THR n 
1 359 SER n 
1 360 ARG n 
1 361 SER n 
1 362 HIS n 
1 363 GLU n 
1 364 PRO n 
1 365 TYR n 
1 366 LEU n 
1 367 LYS n 
1 368 SER n 
1 369 TRP n 
1 370 ALA n 
1 371 GLN n 
1 372 GLU n 
1 373 LEU n 
1 374 GLY n 
1 375 ALA n 
1 376 PRO n 
1 377 ILE n 
1 378 ILE n 
1 379 SER n 
1 380 ILE n 
1 381 ASP n 
1 382 TYR n 
1 383 SER n 
1 384 LEU n 
1 385 ALA n 
1 386 PRO n 
1 387 GLU n 
1 388 ALA n 
1 389 PRO n 
1 390 PHE n 
1 391 PRO n 
1 392 ARG n 
1 393 ALA n 
1 394 LEU n 
1 395 GLU n 
1 396 GLU n 
1 397 CYS n 
1 398 PHE n 
1 399 PHE n 
1 400 ALA n 
1 401 TYR n 
1 402 CYS n 
1 403 TRP n 
1 404 ALA n 
1 405 ILE n 
1 406 LYS n 
1 407 HIS n 
1 408 CYS n 
1 409 ALA n 
1 410 LEU n 
1 411 LEU n 
1 412 GLY n 
1 413 SER n 
1 414 THR n 
1 415 GLY n 
1 416 GLU n 
1 417 ARG n 
1 418 ILE n 
1 419 CYS n 
1 420 LEU n 
1 421 ALA n 
1 422 GLY n 
1 423 ASP n 
1 424 SER n 
1 425 ALA n 
1 426 GLY n 
1 427 GLY n 
1 428 ASN n 
1 429 LEU n 
1 430 CYS n 
1 431 PHE n 
1 432 THR n 
1 433 VAL n 
1 434 ALA n 
1 435 LEU n 
1 436 ARG n 
1 437 ALA n 
1 438 ALA n 
1 439 ALA n 
1 440 TYR n 
1 441 GLY n 
1 442 VAL n 
1 443 ARG n 
1 444 VAL n 
1 445 PRO n 
1 446 ASP n 
1 447 GLY n 
1 448 ILE n 
1 449 MET n 
1 450 ALA n 
1 451 ALA n 
1 452 TYR n 
1 453 PRO n 
1 454 ALA n 
1 455 THR n 
1 456 MET n 
1 457 LEU n 
1 458 GLN n 
1 459 PRO n 
1 460 ALA n 
1 461 ALA n 
1 462 SER n 
1 463 PRO n 
1 464 SER n 
1 465 ARG n 
1 466 LEU n 
1 467 LEU n 
1 468 SER n 
1 469 LEU n 
1 470 MET n 
1 471 ASP n 
1 472 PRO n 
1 473 LEU n 
1 474 LEU n 
1 475 PRO n 
1 476 LEU n 
1 477 SER n 
1 478 VAL n 
1 479 LEU n 
1 480 SER n 
1 481 LYS n 
1 482 CYS n 
1 483 VAL n 
1 484 SER n 
1 485 ALA n 
1 486 TYR n 
1 487 ALA n 
1 488 GLY n 
1 489 ALA n 
1 490 LYS n 
1 491 THR n 
1 492 GLU n 
1 493 ASP n 
1 494 HIS n 
1 495 SER n 
1 496 ASN n 
1 497 SER n 
1 498 ASP n 
1 499 GLN n 
1 500 LYS n 
1 501 ALA n 
1 502 LEU n 
1 503 GLY n 
1 504 MET n 
1 505 MET n 
1 506 GLY n 
1 507 LEU n 
1 508 VAL n 
1 509 ARG n 
1 510 ARG n 
1 511 ASP n 
1 512 THR n 
1 513 ALA n 
1 514 LEU n 
1 515 LEU n 
1 516 LEU n 
1 517 ARG n 
1 518 ASP n 
1 519 PHE n 
1 520 ARG n 
1 521 LEU n 
1 522 GLY n 
1 523 ALA n 
1 524 SER n 
1 525 SER n 
1 526 TRP n 
1 527 LEU n 
1 528 ASN n 
1 529 SER n 
1 530 PHE n 
1 531 LEU n 
1 532 GLU n 
1 533 LEU n 
1 534 SER n 
1 535 GLY n 
1 536 ARG n 
1 537 LYS n 
1 538 SER n 
1 539 GLN n 
1 540 LYS n 
1 541 MET n 
1 542 SER n 
1 543 GLU n 
1 544 PRO n 
1 545 ILE n 
1 546 ALA n 
1 547 GLU n 
1 548 PRO n 
1 549 MET n 
1 550 ARG n 
1 551 ARG n 
1 552 SER n 
1 553 VAL n 
1 554 SER n 
1 555 GLU n 
1 556 ALA n 
1 557 ALA n 
1 558 LEU n 
1 559 ALA n 
1 560 GLN n 
1 561 PRO n 
1 562 GLN n 
1 563 GLY n 
1 564 PRO n 
1 565 LEU n 
1 566 GLY n 
1 567 THR n 
1 568 ASP n 
1 569 SER n 
1 570 LEU n 
1 571 LYS n 
1 572 ASN n 
1 573 LEU n 
1 574 THR n 
1 575 LEU n 
1 576 ARG n 
1 577 ASP n 
1 578 LEU n 
1 579 SER n 
1 580 LEU n 
1 581 ARG n 
1 582 GLY n 
1 583 ASN n 
1 584 SER n 
1 585 GLU n 
1 586 THR n 
1 587 SER n 
1 588 SER n 
1 589 ASP n 
1 590 THR n 
1 591 PRO n 
1 592 GLU n 
1 593 MET n 
1 594 SER n 
1 595 LEU n 
1 596 SER n 
1 597 ALA n 
1 598 GLU n 
1 599 THR n 
1 600 LEU n 
1 601 SER n 
1 602 PRO n 
1 603 SER n 
1 604 THR n 
1 605 PRO n 
1 606 SER n 
1 607 ASP n 
1 608 VAL n 
1 609 ASN n 
1 610 PHE n 
1 611 LEU n 
1 612 LEU n 
1 613 PRO n 
1 614 PRO n 
1 615 GLU n 
1 616 ASP n 
1 617 ALA n 
1 618 GLY n 
1 619 GLU n 
1 620 GLU n 
1 621 ALA n 
1 622 GLU n 
1 623 ALA n 
1 624 LYS n 
1 625 ASN n 
1 626 GLU n 
1 627 LEU n 
1 628 SER n 
1 629 PRO n 
1 630 MET n 
1 631 ASP n 
1 632 ARG n 
1 633 GLY n 
1 634 LEU n 
1 635 GLY n 
1 636 VAL n 
1 637 ARG n 
1 638 ALA n 
1 639 ALA n 
1 640 PHE n 
1 641 PRO n 
1 642 GLU n 
1 643 GLY n 
1 644 PHE n 
1 645 HIS n 
1 646 PRO n 
1 647 ARG n 
1 648 ARG n 
1 649 SER n 
1 650 SER n 
1 651 GLN n 
1 652 GLY n 
1 653 ALA n 
1 654 THR n 
1 655 GLN n 
1 656 MET n 
1 657 PRO n 
1 658 LEU n 
1 659 TYR n 
1 660 SER n 
1 661 SER n 
1 662 PRO n 
1 663 ILE n 
1 664 VAL n 
1 665 LYS n 
1 666 ASN n 
1 667 PRO n 
1 668 PHE n 
1 669 MET n 
1 670 SER n 
1 671 PRO n 
1 672 LEU n 
1 673 LEU n 
1 674 ALA n 
1 675 PRO n 
1 676 ASP n 
1 677 SER n 
1 678 MET n 
1 679 LEU n 
1 680 LYS n 
1 681 SER n 
1 682 LEU n 
1 683 PRO n 
1 684 PRO n 
1 685 VAL n 
1 686 HIS n 
1 687 ILE n 
1 688 VAL n 
1 689 ALA n 
1 690 CYS n 
1 691 ALA n 
1 692 LEU n 
1 693 ASP n 
1 694 PRO n 
1 695 MET n 
1 696 LEU n 
1 697 ASP n 
1 698 ASP n 
1 699 SER n 
1 700 VAL n 
1 701 MET n 
1 702 LEU n 
1 703 ALA n 
1 704 ARG n 
1 705 ARG n 
1 706 LEU n 
1 707 ARG n 
1 708 ASN n 
1 709 LEU n 
1 710 GLY n 
1 711 GLN n 
1 712 PRO n 
1 713 VAL n 
1 714 THR n 
1 715 LEU n 
1 716 ARG n 
1 717 VAL n 
1 718 VAL n 
1 719 GLU n 
1 720 ASP n 
1 721 LEU n 
1 722 PRO n 
1 723 HIS n 
1 724 GLY n 
1 725 PHE n 
1 726 LEU n 
1 727 THR n 
1 728 LEU n 
1 729 ALA n 
1 730 ALA n 
1 731 LEU n 
1 732 CYS n 
1 733 ARG n 
1 734 GLU n 
1 735 THR n 
1 736 ARG n 
1 737 GLN n 
1 738 ALA n 
1 739 ALA n 
1 740 GLU n 
1 741 LEU n 
1 742 CYS n 
1 743 VAL n 
1 744 GLU n 
1 745 ARG n 
1 746 ILE n 
1 747 ARG n 
1 748 LEU n 
1 749 VAL n 
1 750 LEU n 
1 751 THR n 
1 752 PRO n 
1 753 PRO n 
1 754 ALA n 
1 755 GLY n 
1 756 ALA n 
1 757 GLY n 
1 758 PRO n 
1 759 SER n 
1 760 GLY n 
1 761 GLU n 
1 762 THR n 
1 763 GLY n 
1 764 ALA n 
1 765 ALA n 
1 766 GLY n 
1 767 VAL n 
1 768 ASP n 
1 769 GLY n 
1 770 GLY n 
1 771 CYS n 
1 772 GLY n 
1 773 GLY n 
1 774 ARG n 
1 775 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   775 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 LIPE 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ASP 2   2   ?   ?   ?   A . n 
A 1 3   LEU 3   3   ?   ?   ?   A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   THR 5   5   5   THR THR A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   THR 7   7   7   THR THR A . n 
A 1 8   GLN 8   8   8   GLN GLN A . n 
A 1 9   SER 9   9   9   SER SER A . n 
A 1 10  LEU 10  10  10  LEU LEU A . n 
A 1 11  VAL 11  11  11  VAL VAL A . n 
A 1 12  THR 12  12  12  THR THR A . n 
A 1 13  LEU 13  13  13  LEU LEU A . n 
A 1 14  ALA 14  14  14  ALA ALA A . n 
A 1 15  GLU 15  15  15  GLU GLU A . n 
A 1 16  ASP 16  16  16  ASP ASP A . n 
A 1 17  ASN 17  17  17  ASN ASN A . n 
A 1 18  ILE 18  18  18  ILE ILE A . n 
A 1 19  ALA 19  19  19  ALA ALA A . n 
A 1 20  PHE 20  20  20  PHE PHE A . n 
A 1 21  PHE 21  21  21  PHE PHE A . n 
A 1 22  SER 22  22  22  SER SER A . n 
A 1 23  SER 23  23  23  SER SER A . n 
A 1 24  GLN 24  24  24  GLN GLN A . n 
A 1 25  GLY 25  25  25  GLY GLY A . n 
A 1 26  PRO 26  26  26  PRO PRO A . n 
A 1 27  GLY 27  27  27  GLY GLY A . n 
A 1 28  GLU 28  28  28  GLU GLU A . n 
A 1 29  THR 29  29  29  THR THR A . n 
A 1 30  ALA 30  30  30  ALA ALA A . n 
A 1 31  GLN 31  31  31  GLN GLN A . n 
A 1 32  ARG 32  32  32  ARG ARG A . n 
A 1 33  LEU 33  33  33  LEU LEU A . n 
A 1 34  SER 34  34  34  SER SER A . n 
A 1 35  GLY 35  35  35  GLY GLY A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  PHE 37  37  37  PHE PHE A . n 
A 1 38  ALA 38  38  38  ALA ALA A . n 
A 1 39  GLY 39  39  39  GLY GLY A . n 
A 1 40  VAL 40  40  40  VAL VAL A . n 
A 1 41  ARG 41  41  41  ARG ARG A . n 
A 1 42  GLU 42  42  42  GLU GLU A . n 
A 1 43  GLN 43  43  43  GLN GLN A . n 
A 1 44  ALA 44  44  44  ALA ALA A . n 
A 1 45  LEU 45  45  45  LEU LEU A . n 
A 1 46  GLY 46  46  46  GLY GLY A . n 
A 1 47  LEU 47  47  47  LEU LEU A . n 
A 1 48  GLU 48  48  48  GLU GLU A . n 
A 1 49  PRO 49  49  49  PRO PRO A . n 
A 1 50  ALA 50  50  50  ALA ALA A . n 
A 1 51  LEU 51  51  51  LEU LEU A . n 
A 1 52  GLY 52  52  52  GLY GLY A . n 
A 1 53  ARG 53  53  53  ARG ARG A . n 
A 1 54  LEU 54  54  54  LEU LEU A . n 
A 1 55  LEU 55  55  55  LEU LEU A . n 
A 1 56  GLY 56  56  56  GLY GLY A . n 
A 1 57  VAL 57  57  57  VAL VAL A . n 
A 1 58  ALA 58  58  58  ALA ALA A . n 
A 1 59  HIS 59  59  59  HIS HIS A . n 
A 1 60  LEU 60  60  60  LEU LEU A . n 
A 1 61  PHE 61  61  61  PHE PHE A . n 
A 1 62  ASP 62  62  62  ASP ASP A . n 
A 1 63  LEU 63  63  63  LEU LEU A . n 
A 1 64  ASP 64  64  64  ASP ASP A . n 
A 1 65  PRO 65  65  65  PRO PRO A . n 
A 1 66  GLU 66  66  66  GLU GLU A . n 
A 1 67  THR 67  67  67  THR THR A . n 
A 1 68  PRO 68  68  68  PRO PRO A . n 
A 1 69  ALA 69  69  69  ALA ALA A . n 
A 1 70  ASN 70  70  70  ASN ASN A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  TYR 72  72  72  TYR TYR A . n 
A 1 73  ARG 73  73  73  ARG ARG A . n 
A 1 74  SER 74  74  74  SER SER A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  VAL 76  76  76  VAL VAL A . n 
A 1 77  HIS 77  77  77  HIS HIS A . n 
A 1 78  THR 78  78  78  THR THR A . n 
A 1 79  ALA 79  79  79  ALA ALA A . n 
A 1 80  ARG 80  80  80  ARG ARG A . n 
A 1 81  CYS 81  81  81  CYS CYS A . n 
A 1 82  CYS 82  82  82  CYS CYS A . n 
A 1 83  LEU 83  83  83  LEU LEU A . n 
A 1 84  ALA 84  84  84  ALA ALA A . n 
A 1 85  HIS 85  85  85  HIS HIS A . n 
A 1 86  LEU 86  86  86  LEU LEU A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  HIS 88  88  88  HIS HIS A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  SER 90  90  90  SER SER A . n 
A 1 91  ARG 91  91  91  ARG ARG A . n 
A 1 92  TYR 92  92  92  TYR TYR A . n 
A 1 93  VAL 93  93  93  VAL VAL A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  SER 95  95  95  SER SER A . n 
A 1 96  ASN 96  96  96  ASN ASN A . n 
A 1 97  ARG 97  97  97  ARG ARG A . n 
A 1 98  ARG 98  98  98  ARG ARG A . n 
A 1 99  SER 99  99  99  SER SER A . n 
A 1 100 ILE 100 100 100 ILE ILE A . n 
A 1 101 PHE 101 101 101 PHE PHE A . n 
A 1 102 PHE 102 102 102 PHE PHE A . n 
A 1 103 ARG 103 103 103 ARG ARG A . n 
A 1 104 THR 104 104 104 THR THR A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 HIS 106 106 106 HIS HIS A . n 
A 1 107 ASN 107 107 107 ASN ASN A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 ALA 109 109 109 ALA ALA A . n 
A 1 110 GLU 110 110 110 GLU GLU A . n 
A 1 111 LEU 111 111 111 LEU LEU A . n 
A 1 112 GLU 112 112 112 GLU GLU A . n 
A 1 113 ALA 113 113 113 ALA ALA A . n 
A 1 114 TYR 114 114 114 TYR TYR A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 ALA 117 117 117 ALA ALA A . n 
A 1 118 LEU 118 118 118 LEU LEU A . n 
A 1 119 THR 119 119 119 THR THR A . n 
A 1 120 GLN 120 120 120 GLN GLN A . n 
A 1 121 LEU 121 121 121 LEU LEU A . n 
A 1 122 ARG 122 122 122 ARG ARG A . n 
A 1 123 ALA 123 123 123 ALA ALA A . n 
A 1 124 LEU 124 124 124 LEU LEU A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 TYR 127 127 127 TYR TYR A . n 
A 1 128 ALA 128 128 128 ALA ALA A . n 
A 1 129 GLN 129 129 129 GLN GLN A . n 
A 1 130 ARG 130 130 130 ARG ARG A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 VAL 133 133 133 VAL VAL A . n 
A 1 134 THR 134 134 134 THR THR A . n 
A 1 135 ASN 135 135 135 ASN ASN A . n 
A 1 136 ARG 136 136 136 ARG ARG A . n 
A 1 137 PRO 137 137 137 PRO PRO A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 VAL 139 139 139 VAL VAL A . n 
A 1 140 LEU 140 140 140 LEU LEU A . n 
A 1 141 PHE 141 141 141 PHE PHE A . n 
A 1 142 PHE 142 142 142 PHE PHE A . n 
A 1 143 GLU 143 143 143 GLU GLU A . n 
A 1 144 GLY 144 144 144 GLY GLY A . n 
A 1 145 ASP 145 145 145 ASP ASP A . n 
A 1 146 GLU 146 146 146 GLU GLU A . n 
A 1 147 GLY 147 147 147 GLY GLY A . n 
A 1 148 LEU 148 148 148 LEU LEU A . n 
A 1 149 THR 149 149 149 THR THR A . n 
A 1 150 ALA 150 150 150 ALA ALA A . n 
A 1 151 ASP 151 151 151 ASP ASP A . n 
A 1 152 PHE 152 152 152 PHE PHE A . n 
A 1 153 LEU 153 153 153 LEU LEU A . n 
A 1 154 ARG 154 154 154 ARG ARG A . n 
A 1 155 GLU 155 155 155 GLU GLU A . n 
A 1 156 TYR 156 156 156 TYR TYR A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 THR 158 158 158 THR THR A . n 
A 1 159 LEU 159 159 159 LEU LEU A . n 
A 1 160 HIS 160 160 160 HIS HIS A . n 
A 1 161 LYS 161 161 161 LYS LYS A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 CYS 163 163 163 CYS CYS A . n 
A 1 164 PHE 164 164 164 PHE PHE A . n 
A 1 165 TYR 165 165 165 TYR TYR A . n 
A 1 166 GLY 166 166 166 GLY GLY A . n 
A 1 167 ARG 167 167 167 ARG ARG A . n 
A 1 168 CYS 168 168 168 CYS CYS A . n 
A 1 169 LEU 169 169 169 LEU LEU A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 PHE 171 171 171 PHE PHE A . n 
A 1 172 GLN 172 172 172 GLN GLN A . n 
A 1 173 PHE 173 173 173 PHE PHE A . n 
A 1 174 THR 174 174 174 THR THR A . n 
A 1 175 PRO 175 175 175 PRO PRO A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 ILE 177 177 177 ILE ILE A . n 
A 1 178 ARG 178 178 178 ARG ARG A . n 
A 1 179 PRO 179 179 179 PRO PRO A . n 
A 1 180 PHE 180 180 180 PHE PHE A . n 
A 1 181 LEU 181 181 181 LEU LEU A . n 
A 1 182 GLN 182 182 182 GLN GLN A . n 
A 1 183 THR 183 183 183 THR THR A . n 
A 1 184 ILE 184 184 184 ILE ILE A . n 
A 1 185 SER 185 185 185 SER SER A . n 
A 1 186 ILE 186 186 186 ILE ILE A . n 
A 1 187 GLY 187 187 187 GLY GLY A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 VAL 189 189 189 VAL VAL A . n 
A 1 190 SER 190 190 190 SER SER A . n 
A 1 191 PHE 191 191 191 PHE PHE A . n 
A 1 192 GLY 192 192 192 GLY GLY A . n 
A 1 193 GLU 193 193 193 GLU GLU A . n 
A 1 194 HIS 194 194 194 HIS HIS A . n 
A 1 195 TYR 195 195 195 TYR TYR A . n 
A 1 196 LYS 196 196 196 LYS LYS A . n 
A 1 197 ARG 197 197 197 ARG ARG A . n 
A 1 198 ASN 198 198 198 ASN ASN A . n 
A 1 199 GLU 199 199 ?   ?   ?   A . n 
A 1 200 THR 200 200 ?   ?   ?   A . n 
A 1 201 GLY 201 201 ?   ?   ?   A . n 
A 1 202 LEU 202 202 ?   ?   ?   A . n 
A 1 203 SER 203 203 ?   ?   ?   A . n 
A 1 204 VAL 204 204 ?   ?   ?   A . n 
A 1 205 ALA 205 205 ?   ?   ?   A . n 
A 1 206 ALA 206 206 ?   ?   ?   A . n 
A 1 207 SER 207 207 ?   ?   ?   A . n 
A 1 208 SER 208 208 ?   ?   ?   A . n 
A 1 209 LEU 209 209 ?   ?   ?   A . n 
A 1 210 PHE 210 210 ?   ?   ?   A . n 
A 1 211 THR 211 211 ?   ?   ?   A . n 
A 1 212 SER 212 212 ?   ?   ?   A . n 
A 1 213 GLY 213 213 ?   ?   ?   A . n 
A 1 214 ARG 214 214 214 ARG ARG A . n 
A 1 215 PHE 215 215 215 PHE PHE A . n 
A 1 216 ALA 216 216 216 ALA ALA A . n 
A 1 217 ILE 217 217 217 ILE ILE A . n 
A 1 218 ASP 218 218 218 ASP ASP A . n 
A 1 219 PRO 219 219 219 PRO PRO A . n 
A 1 220 GLU 220 220 220 GLU GLU A . n 
A 1 221 LEU 221 221 221 LEU LEU A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 GLY 223 223 223 GLY GLY A . n 
A 1 224 ALA 224 224 224 ALA ALA A . n 
A 1 225 GLU 225 225 225 GLU GLU A . n 
A 1 226 PHE 226 226 226 PHE PHE A . n 
A 1 227 GLU 227 227 227 GLU GLU A . n 
A 1 228 ARG 228 228 228 ARG ARG A . n 
A 1 229 ILE 229 229 229 ILE ILE A . n 
A 1 230 THR 230 230 230 THR THR A . n 
A 1 231 GLN 231 231 231 GLN GLN A . n 
A 1 232 ASN 232 232 232 ASN ASN A . n 
A 1 233 LEU 233 233 233 LEU LEU A . n 
A 1 234 ASP 234 234 234 ASP ASP A . n 
A 1 235 VAL 235 235 235 VAL VAL A . n 
A 1 236 HIS 236 236 236 HIS HIS A . n 
A 1 237 PHE 237 237 237 PHE PHE A . n 
A 1 238 TRP 238 238 238 TRP TRP A . n 
A 1 239 LYS 239 239 239 LYS LYS A . n 
A 1 240 ALA 240 240 240 ALA ALA A . n 
A 1 241 PHE 241 241 241 PHE PHE A . n 
A 1 242 TRP 242 242 242 TRP TRP A . n 
A 1 243 ASN 243 243 243 ASN ASN A . n 
A 1 244 ILE 244 244 244 ILE ILE A . n 
A 1 245 THR 245 245 245 THR THR A . n 
A 1 246 GLU 246 246 246 GLU GLU A . n 
A 1 247 MET 247 247 247 MET MET A . n 
A 1 248 GLU 248 248 248 GLU GLU A . n 
A 1 249 VAL 249 249 249 VAL VAL A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 SER 251 251 251 SER SER A . n 
A 1 252 SER 252 252 252 SER SER A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 ALA 254 254 254 ALA ALA A . n 
A 1 255 ASN 255 255 255 ASN ASN A . n 
A 1 256 MET 256 256 256 MET MET A . n 
A 1 257 ALA 257 257 257 ALA ALA A . n 
A 1 258 SER 258 258 258 SER SER A . n 
A 1 259 ALA 259 259 259 ALA ALA A . n 
A 1 260 THR 260 260 260 THR THR A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 ARG 262 262 262 ARG ARG A . n 
A 1 263 VAL 263 263 263 VAL VAL A . n 
A 1 264 SER 264 264 264 SER SER A . n 
A 1 265 ARG 265 265 265 ARG ARG A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 LEU 267 267 267 LEU LEU A . n 
A 1 268 SER 268 268 268 SER SER A . n 
A 1 269 LEU 269 269 269 LEU LEU A . n 
A 1 270 PRO 270 270 270 PRO PRO A . n 
A 1 271 PRO 271 271 271 PRO PRO A . n 
A 1 272 GLU 272 272 272 GLU GLU A . n 
A 1 273 ALA 273 273 273 ALA ALA A . n 
A 1 274 PHE 274 274 274 PHE PHE A . n 
A 1 275 GLU 275 275 275 GLU GLU A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 PRO 277 277 277 PRO PRO A . n 
A 1 278 LEU 278 278 278 LEU LEU A . n 
A 1 279 THR 279 279 279 THR THR A . n 
A 1 280 ALA 280 280 280 ALA ALA A . n 
A 1 281 ASP 281 281 281 ASP ASP A . n 
A 1 282 PRO 282 282 282 PRO PRO A . n 
A 1 283 THR 283 283 283 THR THR A . n 
A 1 284 LEU 284 284 284 LEU LEU A . n 
A 1 285 THR 285 285 285 THR THR A . n 
A 1 286 VAL 286 286 286 VAL VAL A . n 
A 1 287 THR 287 287 287 THR THR A . n 
A 1 288 ILE 288 288 288 ILE ILE A . n 
A 1 289 SER 289 289 289 SER SER A . n 
A 1 290 PRO 290 290 290 PRO PRO A . n 
A 1 291 PRO 291 291 291 PRO PRO A . n 
A 1 292 LEU 292 292 292 LEU LEU A . n 
A 1 293 ALA 293 293 293 ALA ALA A . n 
A 1 294 HIS 294 294 294 HIS HIS A . n 
A 1 295 THR 295 295 295 THR THR A . n 
A 1 296 GLY 296 296 296 GLY GLY A . n 
A 1 297 PRO 297 297 297 PRO PRO A . n 
A 1 298 GLY 298 298 298 GLY GLY A . n 
A 1 299 PRO 299 299 299 PRO PRO A . n 
A 1 300 VAL 300 300 300 VAL VAL A . n 
A 1 301 LEU 301 301 301 LEU LEU A . n 
A 1 302 VAL 302 302 302 VAL VAL A . n 
A 1 303 ARG 303 303 303 ARG ARG A . n 
A 1 304 LEU 304 304 304 LEU LEU A . n 
A 1 305 ILE 305 305 305 ILE ILE A . n 
A 1 306 SER 306 306 306 SER SER A . n 
A 1 307 TYR 307 307 307 TYR TYR A . n 
A 1 308 ASP 308 308 308 ASP ASP A . n 
A 1 309 LEU 309 309 309 LEU LEU A . n 
A 1 310 ARG 310 310 310 ARG ARG A . n 
A 1 311 GLU 311 311 311 GLU GLU A . n 
A 1 312 GLY 312 312 312 GLY GLY A . n 
A 1 313 GLN 313 313 313 GLN GLN A . n 
A 1 314 ASP 314 314 314 ASP ASP A . n 
A 1 315 SER 315 315 315 SER SER A . n 
A 1 316 GLU 316 316 316 GLU GLU A . n 
A 1 317 GLU 317 317 317 GLU GLU A . n 
A 1 318 LEU 318 318 318 LEU LEU A . n 
A 1 319 SER 319 319 319 SER SER A . n 
A 1 320 SER 320 320 320 SER SER A . n 
A 1 321 LEU 321 321 321 LEU LEU A . n 
A 1 322 ILE 322 322 322 ILE ILE A . n 
A 1 323 LYS 323 323 323 LYS LYS A . n 
A 1 324 SER 324 324 324 SER SER A . n 
A 1 325 ASN 325 325 ?   ?   ?   A . n 
A 1 326 GLY 326 326 ?   ?   ?   A . n 
A 1 327 GLN 327 327 ?   ?   ?   A . n 
A 1 328 ARG 328 328 ?   ?   ?   A . n 
A 1 329 SER 329 329 ?   ?   ?   A . n 
A 1 330 LEU 330 330 ?   ?   ?   A . n 
A 1 331 GLU 331 331 ?   ?   ?   A . n 
A 1 332 LEU 332 332 ?   ?   ?   A . n 
A 1 333 TRP 333 333 ?   ?   ?   A . n 
A 1 334 PRO 334 334 ?   ?   ?   A . n 
A 1 335 ARG 335 335 ?   ?   ?   A . n 
A 1 336 PRO 336 336 ?   ?   ?   A . n 
A 1 337 GLN 337 337 337 GLN GLN A . n 
A 1 338 GLN 338 338 338 GLN GLN A . n 
A 1 339 ALA 339 339 339 ALA ALA A . n 
A 1 340 PRO 340 340 340 PRO PRO A . n 
A 1 341 ARG 341 341 341 ARG ARG A . n 
A 1 342 SER 342 342 342 SER SER A . n 
A 1 343 ARG 343 343 343 ARG ARG A . n 
A 1 344 SER 344 344 344 SER SER A . n 
A 1 345 LEU 345 345 345 LEU LEU A . n 
A 1 346 ILE 346 346 346 ILE ILE A . n 
A 1 347 VAL 347 347 347 VAL VAL A . n 
A 1 348 HIS 348 348 348 HIS HIS A . n 
A 1 349 PHE 349 349 349 PHE PHE A . n 
A 1 350 HIS 350 350 350 HIS HIS A . n 
A 1 351 GLY 351 351 351 GLY GLY A . n 
A 1 352 GLY 352 352 352 GLY GLY A . n 
A 1 353 GLY 353 353 353 GLY GLY A . n 
A 1 354 PHE 354 354 354 PHE PHE A . n 
A 1 355 VAL 355 355 355 VAL VAL A . n 
A 1 356 ALA 356 356 356 ALA ALA A . n 
A 1 357 GLN 357 357 357 GLN GLN A . n 
A 1 358 THR 358 358 358 THR THR A . n 
A 1 359 SER 359 359 359 SER SER A . n 
A 1 360 ARG 360 360 360 ARG ARG A . n 
A 1 361 SER 361 361 361 SER SER A . n 
A 1 362 HIS 362 362 362 HIS HIS A . n 
A 1 363 GLU 363 363 363 GLU GLU A . n 
A 1 364 PRO 364 364 364 PRO PRO A . n 
A 1 365 TYR 365 365 365 TYR TYR A . n 
A 1 366 LEU 366 366 366 LEU LEU A . n 
A 1 367 LYS 367 367 367 LYS LYS A . n 
A 1 368 SER 368 368 368 SER SER A . n 
A 1 369 TRP 369 369 369 TRP TRP A . n 
A 1 370 ALA 370 370 370 ALA ALA A . n 
A 1 371 GLN 371 371 371 GLN GLN A . n 
A 1 372 GLU 372 372 372 GLU GLU A . n 
A 1 373 LEU 373 373 373 LEU LEU A . n 
A 1 374 GLY 374 374 374 GLY GLY A . n 
A 1 375 ALA 375 375 375 ALA ALA A . n 
A 1 376 PRO 376 376 376 PRO PRO A . n 
A 1 377 ILE 377 377 377 ILE ILE A . n 
A 1 378 ILE 378 378 378 ILE ILE A . n 
A 1 379 SER 379 379 379 SER SER A . n 
A 1 380 ILE 380 380 380 ILE ILE A . n 
A 1 381 ASP 381 381 381 ASP ASP A . n 
A 1 382 TYR 382 382 382 TYR TYR A . n 
A 1 383 SER 383 383 383 SER SER A . n 
A 1 384 LEU 384 384 384 LEU LEU A . n 
A 1 385 ALA 385 385 385 ALA ALA A . n 
A 1 386 PRO 386 386 386 PRO PRO A . n 
A 1 387 GLU 387 387 387 GLU GLU A . n 
A 1 388 ALA 388 388 388 ALA ALA A . n 
A 1 389 PRO 389 389 389 PRO PRO A . n 
A 1 390 PHE 390 390 390 PHE PHE A . n 
A 1 391 PRO 391 391 391 PRO PRO A . n 
A 1 392 ARG 392 392 392 ARG ARG A . n 
A 1 393 ALA 393 393 393 ALA ALA A . n 
A 1 394 LEU 394 394 394 LEU LEU A . n 
A 1 395 GLU 395 395 395 GLU GLU A . n 
A 1 396 GLU 396 396 396 GLU GLU A . n 
A 1 397 CYS 397 397 397 CYS CYS A . n 
A 1 398 PHE 398 398 398 PHE PHE A . n 
A 1 399 PHE 399 399 399 PHE PHE A . n 
A 1 400 ALA 400 400 400 ALA ALA A . n 
A 1 401 TYR 401 401 401 TYR TYR A . n 
A 1 402 CYS 402 402 402 CYS CYS A . n 
A 1 403 TRP 403 403 403 TRP TRP A . n 
A 1 404 ALA 404 404 404 ALA ALA A . n 
A 1 405 ILE 405 405 405 ILE ILE A . n 
A 1 406 LYS 406 406 406 LYS LYS A . n 
A 1 407 HIS 407 407 407 HIS HIS A . n 
A 1 408 CYS 408 408 408 CYS CYS A . n 
A 1 409 ALA 409 409 409 ALA ALA A . n 
A 1 410 LEU 410 410 410 LEU LEU A . n 
A 1 411 LEU 411 411 411 LEU LEU A . n 
A 1 412 GLY 412 412 412 GLY GLY A . n 
A 1 413 SER 413 413 413 SER SER A . n 
A 1 414 THR 414 414 414 THR THR A . n 
A 1 415 GLY 415 415 415 GLY GLY A . n 
A 1 416 GLU 416 416 416 GLU GLU A . n 
A 1 417 ARG 417 417 417 ARG ARG A . n 
A 1 418 ILE 418 418 418 ILE ILE A . n 
A 1 419 CYS 419 419 419 CYS CYS A . n 
A 1 420 LEU 420 420 420 LEU LEU A . n 
A 1 421 ALA 421 421 421 ALA ALA A . n 
A 1 422 GLY 422 422 422 GLY GLY A . n 
A 1 423 ASP 423 423 423 ASP ASP A . n 
A 1 424 SER 424 424 424 SER SER A . n 
A 1 425 ALA 425 425 425 ALA ALA A . n 
A 1 426 GLY 426 426 426 GLY GLY A . n 
A 1 427 GLY 427 427 427 GLY GLY A . n 
A 1 428 ASN 428 428 428 ASN ASN A . n 
A 1 429 LEU 429 429 429 LEU LEU A . n 
A 1 430 CYS 430 430 430 CYS CYS A . n 
A 1 431 PHE 431 431 431 PHE PHE A . n 
A 1 432 THR 432 432 432 THR THR A . n 
A 1 433 VAL 433 433 433 VAL VAL A . n 
A 1 434 ALA 434 434 434 ALA ALA A . n 
A 1 435 LEU 435 435 435 LEU LEU A . n 
A 1 436 ARG 436 436 436 ARG ARG A . n 
A 1 437 ALA 437 437 437 ALA ALA A . n 
A 1 438 ALA 438 438 438 ALA ALA A . n 
A 1 439 ALA 439 439 439 ALA ALA A . n 
A 1 440 TYR 440 440 440 TYR TYR A . n 
A 1 441 GLY 441 441 441 GLY GLY A . n 
A 1 442 VAL 442 442 442 VAL VAL A . n 
A 1 443 ARG 443 443 443 ARG ARG A . n 
A 1 444 VAL 444 444 444 VAL VAL A . n 
A 1 445 PRO 445 445 445 PRO PRO A . n 
A 1 446 ASP 446 446 446 ASP ASP A . n 
A 1 447 GLY 447 447 447 GLY GLY A . n 
A 1 448 ILE 448 448 448 ILE ILE A . n 
A 1 449 MET 449 449 449 MET MET A . n 
A 1 450 ALA 450 450 450 ALA ALA A . n 
A 1 451 ALA 451 451 451 ALA ALA A . n 
A 1 452 TYR 452 452 452 TYR TYR A . n 
A 1 453 PRO 453 453 453 PRO PRO A . n 
A 1 454 ALA 454 454 454 ALA ALA A . n 
A 1 455 THR 455 455 455 THR THR A . n 
A 1 456 MET 456 456 456 MET MET A . n 
A 1 457 LEU 457 457 457 LEU LEU A . n 
A 1 458 GLN 458 458 458 GLN GLN A . n 
A 1 459 PRO 459 459 459 PRO PRO A . n 
A 1 460 ALA 460 460 460 ALA ALA A . n 
A 1 461 ALA 461 461 461 ALA ALA A . n 
A 1 462 SER 462 462 462 SER SER A . n 
A 1 463 PRO 463 463 463 PRO PRO A . n 
A 1 464 SER 464 464 464 SER SER A . n 
A 1 465 ARG 465 465 465 ARG ARG A . n 
A 1 466 LEU 466 466 466 LEU LEU A . n 
A 1 467 LEU 467 467 467 LEU LEU A . n 
A 1 468 SER 468 468 468 SER SER A . n 
A 1 469 LEU 469 469 469 LEU LEU A . n 
A 1 470 MET 470 470 470 MET MET A . n 
A 1 471 ASP 471 471 471 ASP ASP A . n 
A 1 472 PRO 472 472 472 PRO PRO A . n 
A 1 473 LEU 473 473 473 LEU LEU A . n 
A 1 474 LEU 474 474 474 LEU LEU A . n 
A 1 475 PRO 475 475 475 PRO PRO A . n 
A 1 476 LEU 476 476 476 LEU LEU A . n 
A 1 477 SER 477 477 477 SER SER A . n 
A 1 478 VAL 478 478 478 VAL VAL A . n 
A 1 479 LEU 479 479 479 LEU LEU A . n 
A 1 480 SER 480 480 480 SER SER A . n 
A 1 481 LYS 481 481 481 LYS LYS A . n 
A 1 482 CYS 482 482 482 CYS CYS A . n 
A 1 483 VAL 483 483 483 VAL VAL A . n 
A 1 484 SER 484 484 484 SER SER A . n 
A 1 485 ALA 485 485 485 ALA ALA A . n 
A 1 486 TYR 486 486 486 TYR TYR A . n 
A 1 487 ALA 487 487 487 ALA ALA A . n 
A 1 488 GLY 488 488 488 GLY GLY A . n 
A 1 489 ALA 489 489 489 ALA ALA A . n 
A 1 490 LYS 490 490 490 LYS LYS A . n 
A 1 491 THR 491 491 491 THR THR A . n 
A 1 492 GLU 492 492 ?   ?   ?   A . n 
A 1 493 ASP 493 493 ?   ?   ?   A . n 
A 1 494 HIS 494 494 ?   ?   ?   A . n 
A 1 495 SER 495 495 ?   ?   ?   A . n 
A 1 496 ASN 496 496 ?   ?   ?   A . n 
A 1 497 SER 497 497 ?   ?   ?   A . n 
A 1 498 ASP 498 498 ?   ?   ?   A . n 
A 1 499 GLN 499 499 ?   ?   ?   A . n 
A 1 500 LYS 500 500 ?   ?   ?   A . n 
A 1 501 ALA 501 501 ?   ?   ?   A . n 
A 1 502 LEU 502 502 ?   ?   ?   A . n 
A 1 503 GLY 503 503 ?   ?   ?   A . n 
A 1 504 MET 504 504 ?   ?   ?   A . n 
A 1 505 MET 505 505 ?   ?   ?   A . n 
A 1 506 GLY 506 506 ?   ?   ?   A . n 
A 1 507 LEU 507 507 ?   ?   ?   A . n 
A 1 508 VAL 508 508 ?   ?   ?   A . n 
A 1 509 ARG 509 509 ?   ?   ?   A . n 
A 1 510 ARG 510 510 ?   ?   ?   A . n 
A 1 511 ASP 511 511 ?   ?   ?   A . n 
A 1 512 THR 512 512 ?   ?   ?   A . n 
A 1 513 ALA 513 513 ?   ?   ?   A . n 
A 1 514 LEU 514 514 ?   ?   ?   A . n 
A 1 515 LEU 515 515 ?   ?   ?   A . n 
A 1 516 LEU 516 516 ?   ?   ?   A . n 
A 1 517 ARG 517 517 ?   ?   ?   A . n 
A 1 518 ASP 518 518 ?   ?   ?   A . n 
A 1 519 PHE 519 519 ?   ?   ?   A . n 
A 1 520 ARG 520 520 ?   ?   ?   A . n 
A 1 521 LEU 521 521 ?   ?   ?   A . n 
A 1 522 GLY 522 522 ?   ?   ?   A . n 
A 1 523 ALA 523 523 ?   ?   ?   A . n 
A 1 524 SER 524 524 ?   ?   ?   A . n 
A 1 525 SER 525 525 ?   ?   ?   A . n 
A 1 526 TRP 526 526 ?   ?   ?   A . n 
A 1 527 LEU 527 527 ?   ?   ?   A . n 
A 1 528 ASN 528 528 ?   ?   ?   A . n 
A 1 529 SER 529 529 ?   ?   ?   A . n 
A 1 530 PHE 530 530 ?   ?   ?   A . n 
A 1 531 LEU 531 531 ?   ?   ?   A . n 
A 1 532 GLU 532 532 ?   ?   ?   A . n 
A 1 533 LEU 533 533 ?   ?   ?   A . n 
A 1 534 SER 534 534 ?   ?   ?   A . n 
A 1 535 GLY 535 535 ?   ?   ?   A . n 
A 1 536 ARG 536 536 ?   ?   ?   A . n 
A 1 537 LYS 537 537 ?   ?   ?   A . n 
A 1 538 SER 538 538 ?   ?   ?   A . n 
A 1 539 GLN 539 539 ?   ?   ?   A . n 
A 1 540 LYS 540 540 ?   ?   ?   A . n 
A 1 541 MET 541 541 ?   ?   ?   A . n 
A 1 542 SER 542 542 ?   ?   ?   A . n 
A 1 543 GLU 543 543 ?   ?   ?   A . n 
A 1 544 PRO 544 544 ?   ?   ?   A . n 
A 1 545 ILE 545 545 ?   ?   ?   A . n 
A 1 546 ALA 546 546 ?   ?   ?   A . n 
A 1 547 GLU 547 547 ?   ?   ?   A . n 
A 1 548 PRO 548 548 ?   ?   ?   A . n 
A 1 549 MET 549 549 ?   ?   ?   A . n 
A 1 550 ARG 550 550 ?   ?   ?   A . n 
A 1 551 ARG 551 551 ?   ?   ?   A . n 
A 1 552 SER 552 552 ?   ?   ?   A . n 
A 1 553 VAL 553 553 ?   ?   ?   A . n 
A 1 554 SER 554 554 ?   ?   ?   A . n 
A 1 555 GLU 555 555 ?   ?   ?   A . n 
A 1 556 ALA 556 556 ?   ?   ?   A . n 
A 1 557 ALA 557 557 ?   ?   ?   A . n 
A 1 558 LEU 558 558 ?   ?   ?   A . n 
A 1 559 ALA 559 559 ?   ?   ?   A . n 
A 1 560 GLN 560 560 ?   ?   ?   A . n 
A 1 561 PRO 561 561 ?   ?   ?   A . n 
A 1 562 GLN 562 562 ?   ?   ?   A . n 
A 1 563 GLY 563 563 ?   ?   ?   A . n 
A 1 564 PRO 564 564 ?   ?   ?   A . n 
A 1 565 LEU 565 565 ?   ?   ?   A . n 
A 1 566 GLY 566 566 ?   ?   ?   A . n 
A 1 567 THR 567 567 ?   ?   ?   A . n 
A 1 568 ASP 568 568 ?   ?   ?   A . n 
A 1 569 SER 569 569 ?   ?   ?   A . n 
A 1 570 LEU 570 570 ?   ?   ?   A . n 
A 1 571 LYS 571 571 ?   ?   ?   A . n 
A 1 572 ASN 572 572 ?   ?   ?   A . n 
A 1 573 LEU 573 573 ?   ?   ?   A . n 
A 1 574 THR 574 574 ?   ?   ?   A . n 
A 1 575 LEU 575 575 ?   ?   ?   A . n 
A 1 576 ARG 576 576 ?   ?   ?   A . n 
A 1 577 ASP 577 577 ?   ?   ?   A . n 
A 1 578 LEU 578 578 ?   ?   ?   A . n 
A 1 579 SER 579 579 ?   ?   ?   A . n 
A 1 580 LEU 580 580 ?   ?   ?   A . n 
A 1 581 ARG 581 581 ?   ?   ?   A . n 
A 1 582 GLY 582 582 ?   ?   ?   A . n 
A 1 583 ASN 583 583 ?   ?   ?   A . n 
A 1 584 SER 584 584 ?   ?   ?   A . n 
A 1 585 GLU 585 585 ?   ?   ?   A . n 
A 1 586 THR 586 586 ?   ?   ?   A . n 
A 1 587 SER 587 587 ?   ?   ?   A . n 
A 1 588 SER 588 588 ?   ?   ?   A . n 
A 1 589 ASP 589 589 ?   ?   ?   A . n 
A 1 590 THR 590 590 ?   ?   ?   A . n 
A 1 591 PRO 591 591 ?   ?   ?   A . n 
A 1 592 GLU 592 592 ?   ?   ?   A . n 
A 1 593 MET 593 593 ?   ?   ?   A . n 
A 1 594 SER 594 594 ?   ?   ?   A . n 
A 1 595 LEU 595 595 ?   ?   ?   A . n 
A 1 596 SER 596 596 ?   ?   ?   A . n 
A 1 597 ALA 597 597 ?   ?   ?   A . n 
A 1 598 GLU 598 598 ?   ?   ?   A . n 
A 1 599 THR 599 599 ?   ?   ?   A . n 
A 1 600 LEU 600 600 ?   ?   ?   A . n 
A 1 601 SER 601 601 ?   ?   ?   A . n 
A 1 602 PRO 602 602 ?   ?   ?   A . n 
A 1 603 SER 603 603 ?   ?   ?   A . n 
A 1 604 THR 604 604 ?   ?   ?   A . n 
A 1 605 PRO 605 605 ?   ?   ?   A . n 
A 1 606 SER 606 606 ?   ?   ?   A . n 
A 1 607 ASP 607 607 ?   ?   ?   A . n 
A 1 608 VAL 608 608 ?   ?   ?   A . n 
A 1 609 ASN 609 609 ?   ?   ?   A . n 
A 1 610 PHE 610 610 ?   ?   ?   A . n 
A 1 611 LEU 611 611 ?   ?   ?   A . n 
A 1 612 LEU 612 612 ?   ?   ?   A . n 
A 1 613 PRO 613 613 ?   ?   ?   A . n 
A 1 614 PRO 614 614 ?   ?   ?   A . n 
A 1 615 GLU 615 615 ?   ?   ?   A . n 
A 1 616 ASP 616 616 ?   ?   ?   A . n 
A 1 617 ALA 617 617 ?   ?   ?   A . n 
A 1 618 GLY 618 618 ?   ?   ?   A . n 
A 1 619 GLU 619 619 ?   ?   ?   A . n 
A 1 620 GLU 620 620 ?   ?   ?   A . n 
A 1 621 ALA 621 621 ?   ?   ?   A . n 
A 1 622 GLU 622 622 ?   ?   ?   A . n 
A 1 623 ALA 623 623 ?   ?   ?   A . n 
A 1 624 LYS 624 624 ?   ?   ?   A . n 
A 1 625 ASN 625 625 ?   ?   ?   A . n 
A 1 626 GLU 626 626 ?   ?   ?   A . n 
A 1 627 LEU 627 627 ?   ?   ?   A . n 
A 1 628 SER 628 628 ?   ?   ?   A . n 
A 1 629 PRO 629 629 ?   ?   ?   A . n 
A 1 630 MET 630 630 ?   ?   ?   A . n 
A 1 631 ASP 631 631 ?   ?   ?   A . n 
A 1 632 ARG 632 632 ?   ?   ?   A . n 
A 1 633 GLY 633 633 ?   ?   ?   A . n 
A 1 634 LEU 634 634 ?   ?   ?   A . n 
A 1 635 GLY 635 635 ?   ?   ?   A . n 
A 1 636 VAL 636 636 ?   ?   ?   A . n 
A 1 637 ARG 637 637 ?   ?   ?   A . n 
A 1 638 ALA 638 638 638 ALA ALA A . n 
A 1 639 ALA 639 639 639 ALA ALA A . n 
A 1 640 PHE 640 640 640 PHE PHE A . n 
A 1 641 PRO 641 641 641 PRO PRO A . n 
A 1 642 GLU 642 642 642 GLU GLU A . n 
A 1 643 GLY 643 643 643 GLY GLY A . n 
A 1 644 PHE 644 644 644 PHE PHE A . n 
A 1 645 HIS 645 645 645 HIS HIS A . n 
A 1 646 PRO 646 646 646 PRO PRO A . n 
A 1 647 ARG 647 647 647 ARG ARG A . n 
A 1 648 ARG 648 648 648 ARG ARG A . n 
A 1 649 SER 649 649 649 SER SER A . n 
A 1 650 SER 650 650 650 SER SER A . n 
A 1 651 GLN 651 651 651 GLN GLN A . n 
A 1 652 GLY 652 652 652 GLY GLY A . n 
A 1 653 ALA 653 653 653 ALA ALA A . n 
A 1 654 THR 654 654 654 THR THR A . n 
A 1 655 GLN 655 655 655 GLN GLN A . n 
A 1 656 MET 656 656 656 MET MET A . n 
A 1 657 PRO 657 657 657 PRO PRO A . n 
A 1 658 LEU 658 658 658 LEU LEU A . n 
A 1 659 TYR 659 659 659 TYR TYR A . n 
A 1 660 SER 660 660 660 SER SER A . n 
A 1 661 SER 661 661 661 SER SER A . n 
A 1 662 PRO 662 662 662 PRO PRO A . n 
A 1 663 ILE 663 663 663 ILE ILE A . n 
A 1 664 VAL 664 664 664 VAL VAL A . n 
A 1 665 LYS 665 665 665 LYS LYS A . n 
A 1 666 ASN 666 666 666 ASN ASN A . n 
A 1 667 PRO 667 667 667 PRO PRO A . n 
A 1 668 PHE 668 668 668 PHE PHE A . n 
A 1 669 MET 669 669 669 MET MET A . n 
A 1 670 SER 670 670 670 SER SER A . n 
A 1 671 PRO 671 671 671 PRO PRO A . n 
A 1 672 LEU 672 672 672 LEU LEU A . n 
A 1 673 LEU 673 673 673 LEU LEU A . n 
A 1 674 ALA 674 674 674 ALA ALA A . n 
A 1 675 PRO 675 675 675 PRO PRO A . n 
A 1 676 ASP 676 676 676 ASP ASP A . n 
A 1 677 SER 677 677 677 SER SER A . n 
A 1 678 MET 678 678 678 MET MET A . n 
A 1 679 LEU 679 679 679 LEU LEU A . n 
A 1 680 LYS 680 680 680 LYS LYS A . n 
A 1 681 SER 681 681 681 SER SER A . n 
A 1 682 LEU 682 682 682 LEU LEU A . n 
A 1 683 PRO 683 683 683 PRO PRO A . n 
A 1 684 PRO 684 684 684 PRO PRO A . n 
A 1 685 VAL 685 685 685 VAL VAL A . n 
A 1 686 HIS 686 686 686 HIS HIS A . n 
A 1 687 ILE 687 687 687 ILE ILE A . n 
A 1 688 VAL 688 688 688 VAL VAL A . n 
A 1 689 ALA 689 689 689 ALA ALA A . n 
A 1 690 CYS 690 690 690 CYS CYS A . n 
A 1 691 ALA 691 691 691 ALA ALA A . n 
A 1 692 LEU 692 692 692 LEU LEU A . n 
A 1 693 ASP 693 693 693 ASP ASP A . n 
A 1 694 PRO 694 694 694 PRO PRO A . n 
A 1 695 MET 695 695 695 MET MET A . n 
A 1 696 LEU 696 696 696 LEU LEU A . n 
A 1 697 ASP 697 697 697 ASP ASP A . n 
A 1 698 ASP 698 698 698 ASP ASP A . n 
A 1 699 SER 699 699 699 SER SER A . n 
A 1 700 VAL 700 700 700 VAL VAL A . n 
A 1 701 MET 701 701 701 MET MET A . n 
A 1 702 LEU 702 702 702 LEU LEU A . n 
A 1 703 ALA 703 703 703 ALA ALA A . n 
A 1 704 ARG 704 704 704 ARG ARG A . n 
A 1 705 ARG 705 705 705 ARG ARG A . n 
A 1 706 LEU 706 706 706 LEU LEU A . n 
A 1 707 ARG 707 707 707 ARG ARG A . n 
A 1 708 ASN 708 708 708 ASN ASN A . n 
A 1 709 LEU 709 709 709 LEU LEU A . n 
A 1 710 GLY 710 710 710 GLY GLY A . n 
A 1 711 GLN 711 711 711 GLN GLN A . n 
A 1 712 PRO 712 712 712 PRO PRO A . n 
A 1 713 VAL 713 713 713 VAL VAL A . n 
A 1 714 THR 714 714 714 THR THR A . n 
A 1 715 LEU 715 715 715 LEU LEU A . n 
A 1 716 ARG 716 716 716 ARG ARG A . n 
A 1 717 VAL 717 717 717 VAL VAL A . n 
A 1 718 VAL 718 718 718 VAL VAL A . n 
A 1 719 GLU 719 719 719 GLU GLU A . n 
A 1 720 ASP 720 720 720 ASP ASP A . n 
A 1 721 LEU 721 721 721 LEU LEU A . n 
A 1 722 PRO 722 722 722 PRO PRO A . n 
A 1 723 HIS 723 723 723 HIS HIS A . n 
A 1 724 GLY 724 724 724 GLY GLY A . n 
A 1 725 PHE 725 725 725 PHE PHE A . n 
A 1 726 LEU 726 726 726 LEU LEU A . n 
A 1 727 THR 727 727 727 THR THR A . n 
A 1 728 LEU 728 728 728 LEU LEU A . n 
A 1 729 ALA 729 729 729 ALA ALA A . n 
A 1 730 ALA 730 730 730 ALA ALA A . n 
A 1 731 LEU 731 731 731 LEU LEU A . n 
A 1 732 CYS 732 732 732 CYS CYS A . n 
A 1 733 ARG 733 733 733 ARG ARG A . n 
A 1 734 GLU 734 734 734 GLU GLU A . n 
A 1 735 THR 735 735 735 THR THR A . n 
A 1 736 ARG 736 736 736 ARG ARG A . n 
A 1 737 GLN 737 737 737 GLN GLN A . n 
A 1 738 ALA 738 738 738 ALA ALA A . n 
A 1 739 ALA 739 739 739 ALA ALA A . n 
A 1 740 GLU 740 740 740 GLU GLU A . n 
A 1 741 LEU 741 741 741 LEU LEU A . n 
A 1 742 CYS 742 742 742 CYS CYS A . n 
A 1 743 VAL 743 743 743 VAL VAL A . n 
A 1 744 GLU 744 744 744 GLU GLU A . n 
A 1 745 ARG 745 745 745 ARG ARG A . n 
A 1 746 ILE 746 746 746 ILE ILE A . n 
A 1 747 ARG 747 747 747 ARG ARG A . n 
A 1 748 LEU 748 748 748 LEU LEU A . n 
A 1 749 VAL 749 749 749 VAL VAL A . n 
A 1 750 LEU 750 750 750 LEU LEU A . n 
A 1 751 THR 751 751 751 THR THR A . n 
A 1 752 PRO 752 752 752 PRO PRO A . n 
A 1 753 PRO 753 753 ?   ?   ?   A . n 
A 1 754 ALA 754 754 ?   ?   ?   A . n 
A 1 755 GLY 755 755 ?   ?   ?   A . n 
A 1 756 ALA 756 756 ?   ?   ?   A . n 
A 1 757 GLY 757 757 ?   ?   ?   A . n 
A 1 758 PRO 758 758 ?   ?   ?   A . n 
A 1 759 SER 759 759 ?   ?   ?   A . n 
A 1 760 GLY 760 760 ?   ?   ?   A . n 
A 1 761 GLU 761 761 ?   ?   ?   A . n 
A 1 762 THR 762 762 ?   ?   ?   A . n 
A 1 763 GLY 763 763 ?   ?   ?   A . n 
A 1 764 ALA 764 764 ?   ?   ?   A . n 
A 1 765 ALA 765 765 ?   ?   ?   A . n 
A 1 766 GLY 766 766 ?   ?   ?   A . n 
A 1 767 VAL 767 767 ?   ?   ?   A . n 
A 1 768 ASP 768 768 ?   ?   ?   A . n 
A 1 769 GLY 769 769 ?   ?   ?   A . n 
A 1 770 GLY 770 770 ?   ?   ?   A . n 
A 1 771 CYS 771 771 ?   ?   ?   A . n 
A 1 772 GLY 772 772 ?   ?   ?   A . n 
A 1 773 GLY 773 773 ?   ?   ?   A . n 
A 1 774 ARG 774 774 ?   ?   ?   A . n 
A 1 775 HIS 775 775 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   ASP 2   2   ?   ?   ?   B . n 
B 1 3   LEU 3   3   ?   ?   ?   B . n 
B 1 4   ARG 4   4   4   ARG ARG B . n 
B 1 5   THR 5   5   5   THR THR B . n 
B 1 6   MET 6   6   6   MET MET B . n 
B 1 7   THR 7   7   7   THR THR B . n 
B 1 8   GLN 8   8   8   GLN GLN B . n 
B 1 9   SER 9   9   9   SER SER B . n 
B 1 10  LEU 10  10  10  LEU LEU B . n 
B 1 11  VAL 11  11  11  VAL VAL B . n 
B 1 12  THR 12  12  12  THR THR B . n 
B 1 13  LEU 13  13  13  LEU LEU B . n 
B 1 14  ALA 14  14  14  ALA ALA B . n 
B 1 15  GLU 15  15  15  GLU GLU B . n 
B 1 16  ASP 16  16  16  ASP ASP B . n 
B 1 17  ASN 17  17  17  ASN ASN B . n 
B 1 18  ILE 18  18  18  ILE ILE B . n 
B 1 19  ALA 19  19  19  ALA ALA B . n 
B 1 20  PHE 20  20  20  PHE PHE B . n 
B 1 21  PHE 21  21  21  PHE PHE B . n 
B 1 22  SER 22  22  22  SER SER B . n 
B 1 23  SER 23  23  23  SER SER B . n 
B 1 24  GLN 24  24  24  GLN GLN B . n 
B 1 25  GLY 25  25  25  GLY GLY B . n 
B 1 26  PRO 26  26  26  PRO PRO B . n 
B 1 27  GLY 27  27  27  GLY GLY B . n 
B 1 28  GLU 28  28  28  GLU GLU B . n 
B 1 29  THR 29  29  29  THR THR B . n 
B 1 30  ALA 30  30  30  ALA ALA B . n 
B 1 31  GLN 31  31  31  GLN GLN B . n 
B 1 32  ARG 32  32  32  ARG ARG B . n 
B 1 33  LEU 33  33  33  LEU LEU B . n 
B 1 34  SER 34  34  34  SER SER B . n 
B 1 35  GLY 35  35  35  GLY GLY B . n 
B 1 36  VAL 36  36  36  VAL VAL B . n 
B 1 37  PHE 37  37  37  PHE PHE B . n 
B 1 38  ALA 38  38  38  ALA ALA B . n 
B 1 39  GLY 39  39  39  GLY GLY B . n 
B 1 40  VAL 40  40  40  VAL VAL B . n 
B 1 41  ARG 41  41  41  ARG ARG B . n 
B 1 42  GLU 42  42  42  GLU GLU B . n 
B 1 43  GLN 43  43  43  GLN GLN B . n 
B 1 44  ALA 44  44  44  ALA ALA B . n 
B 1 45  LEU 45  45  45  LEU LEU B . n 
B 1 46  GLY 46  46  46  GLY GLY B . n 
B 1 47  LEU 47  47  47  LEU LEU B . n 
B 1 48  GLU 48  48  48  GLU GLU B . n 
B 1 49  PRO 49  49  49  PRO PRO B . n 
B 1 50  ALA 50  50  50  ALA ALA B . n 
B 1 51  LEU 51  51  51  LEU LEU B . n 
B 1 52  GLY 52  52  52  GLY GLY B . n 
B 1 53  ARG 53  53  53  ARG ARG B . n 
B 1 54  LEU 54  54  54  LEU LEU B . n 
B 1 55  LEU 55  55  55  LEU LEU B . n 
B 1 56  GLY 56  56  56  GLY GLY B . n 
B 1 57  VAL 57  57  57  VAL VAL B . n 
B 1 58  ALA 58  58  58  ALA ALA B . n 
B 1 59  HIS 59  59  59  HIS HIS B . n 
B 1 60  LEU 60  60  60  LEU LEU B . n 
B 1 61  PHE 61  61  61  PHE PHE B . n 
B 1 62  ASP 62  62  62  ASP ASP B . n 
B 1 63  LEU 63  63  63  LEU LEU B . n 
B 1 64  ASP 64  64  64  ASP ASP B . n 
B 1 65  PRO 65  65  65  PRO PRO B . n 
B 1 66  GLU 66  66  66  GLU GLU B . n 
B 1 67  THR 67  67  67  THR THR B . n 
B 1 68  PRO 68  68  68  PRO PRO B . n 
B 1 69  ALA 69  69  69  ALA ALA B . n 
B 1 70  ASN 70  70  70  ASN ASN B . n 
B 1 71  GLY 71  71  71  GLY GLY B . n 
B 1 72  TYR 72  72  72  TYR TYR B . n 
B 1 73  ARG 73  73  73  ARG ARG B . n 
B 1 74  SER 74  74  74  SER SER B . n 
B 1 75  LEU 75  75  75  LEU LEU B . n 
B 1 76  VAL 76  76  76  VAL VAL B . n 
B 1 77  HIS 77  77  77  HIS HIS B . n 
B 1 78  THR 78  78  78  THR THR B . n 
B 1 79  ALA 79  79  79  ALA ALA B . n 
B 1 80  ARG 80  80  80  ARG ARG B . n 
B 1 81  CYS 81  81  81  CYS CYS B . n 
B 1 82  CYS 82  82  82  CYS CYS B . n 
B 1 83  LEU 83  83  83  LEU LEU B . n 
B 1 84  ALA 84  84  84  ALA ALA B . n 
B 1 85  HIS 85  85  85  HIS HIS B . n 
B 1 86  LEU 86  86  86  LEU LEU B . n 
B 1 87  LEU 87  87  87  LEU LEU B . n 
B 1 88  HIS 88  88  88  HIS HIS B . n 
B 1 89  LYS 89  89  89  LYS LYS B . n 
B 1 90  SER 90  90  90  SER SER B . n 
B 1 91  ARG 91  91  91  ARG ARG B . n 
B 1 92  TYR 92  92  92  TYR TYR B . n 
B 1 93  VAL 93  93  93  VAL VAL B . n 
B 1 94  ALA 94  94  94  ALA ALA B . n 
B 1 95  SER 95  95  95  SER SER B . n 
B 1 96  ASN 96  96  96  ASN ASN B . n 
B 1 97  ARG 97  97  97  ARG ARG B . n 
B 1 98  ARG 98  98  98  ARG ARG B . n 
B 1 99  SER 99  99  99  SER SER B . n 
B 1 100 ILE 100 100 100 ILE ILE B . n 
B 1 101 PHE 101 101 101 PHE PHE B . n 
B 1 102 PHE 102 102 102 PHE PHE B . n 
B 1 103 ARG 103 103 103 ARG ARG B . n 
B 1 104 THR 104 104 104 THR THR B . n 
B 1 105 SER 105 105 105 SER SER B . n 
B 1 106 HIS 106 106 106 HIS HIS B . n 
B 1 107 ASN 107 107 107 ASN ASN B . n 
B 1 108 LEU 108 108 108 LEU LEU B . n 
B 1 109 ALA 109 109 109 ALA ALA B . n 
B 1 110 GLU 110 110 110 GLU GLU B . n 
B 1 111 LEU 111 111 111 LEU LEU B . n 
B 1 112 GLU 112 112 112 GLU GLU B . n 
B 1 113 ALA 113 113 113 ALA ALA B . n 
B 1 114 TYR 114 114 114 TYR TYR B . n 
B 1 115 LEU 115 115 115 LEU LEU B . n 
B 1 116 ALA 116 116 116 ALA ALA B . n 
B 1 117 ALA 117 117 117 ALA ALA B . n 
B 1 118 LEU 118 118 118 LEU LEU B . n 
B 1 119 THR 119 119 119 THR THR B . n 
B 1 120 GLN 120 120 120 GLN GLN B . n 
B 1 121 LEU 121 121 121 LEU LEU B . n 
B 1 122 ARG 122 122 122 ARG ARG B . n 
B 1 123 ALA 123 123 123 ALA ALA B . n 
B 1 124 LEU 124 124 124 LEU LEU B . n 
B 1 125 VAL 125 125 125 VAL VAL B . n 
B 1 126 TYR 126 126 126 TYR TYR B . n 
B 1 127 TYR 127 127 127 TYR TYR B . n 
B 1 128 ALA 128 128 128 ALA ALA B . n 
B 1 129 GLN 129 129 129 GLN GLN B . n 
B 1 130 ARG 130 130 130 ARG ARG B . n 
B 1 131 LEU 131 131 131 LEU LEU B . n 
B 1 132 LEU 132 132 132 LEU LEU B . n 
B 1 133 VAL 133 133 133 VAL VAL B . n 
B 1 134 THR 134 134 134 THR THR B . n 
B 1 135 ASN 135 135 135 ASN ASN B . n 
B 1 136 ARG 136 136 136 ARG ARG B . n 
B 1 137 PRO 137 137 137 PRO PRO B . n 
B 1 138 GLY 138 138 138 GLY GLY B . n 
B 1 139 VAL 139 139 139 VAL VAL B . n 
B 1 140 LEU 140 140 140 LEU LEU B . n 
B 1 141 PHE 141 141 141 PHE PHE B . n 
B 1 142 PHE 142 142 142 PHE PHE B . n 
B 1 143 GLU 143 143 143 GLU GLU B . n 
B 1 144 GLY 144 144 144 GLY GLY B . n 
B 1 145 ASP 145 145 145 ASP ASP B . n 
B 1 146 GLU 146 146 146 GLU GLU B . n 
B 1 147 GLY 147 147 147 GLY GLY B . n 
B 1 148 LEU 148 148 148 LEU LEU B . n 
B 1 149 THR 149 149 149 THR THR B . n 
B 1 150 ALA 150 150 150 ALA ALA B . n 
B 1 151 ASP 151 151 151 ASP ASP B . n 
B 1 152 PHE 152 152 152 PHE PHE B . n 
B 1 153 LEU 153 153 153 LEU LEU B . n 
B 1 154 ARG 154 154 154 ARG ARG B . n 
B 1 155 GLU 155 155 155 GLU GLU B . n 
B 1 156 TYR 156 156 156 TYR TYR B . n 
B 1 157 VAL 157 157 157 VAL VAL B . n 
B 1 158 THR 158 158 158 THR THR B . n 
B 1 159 LEU 159 159 159 LEU LEU B . n 
B 1 160 HIS 160 160 160 HIS HIS B . n 
B 1 161 LYS 161 161 161 LYS LYS B . n 
B 1 162 GLY 162 162 162 GLY GLY B . n 
B 1 163 CYS 163 163 163 CYS CYS B . n 
B 1 164 PHE 164 164 164 PHE PHE B . n 
B 1 165 TYR 165 165 165 TYR TYR B . n 
B 1 166 GLY 166 166 166 GLY GLY B . n 
B 1 167 ARG 167 167 167 ARG ARG B . n 
B 1 168 CYS 168 168 168 CYS CYS B . n 
B 1 169 LEU 169 169 169 LEU LEU B . n 
B 1 170 GLY 170 170 170 GLY GLY B . n 
B 1 171 PHE 171 171 171 PHE PHE B . n 
B 1 172 GLN 172 172 172 GLN GLN B . n 
B 1 173 PHE 173 173 173 PHE PHE B . n 
B 1 174 THR 174 174 174 THR THR B . n 
B 1 175 PRO 175 175 175 PRO PRO B . n 
B 1 176 ALA 176 176 176 ALA ALA B . n 
B 1 177 ILE 177 177 177 ILE ILE B . n 
B 1 178 ARG 178 178 178 ARG ARG B . n 
B 1 179 PRO 179 179 179 PRO PRO B . n 
B 1 180 PHE 180 180 180 PHE PHE B . n 
B 1 181 LEU 181 181 181 LEU LEU B . n 
B 1 182 GLN 182 182 182 GLN GLN B . n 
B 1 183 THR 183 183 183 THR THR B . n 
B 1 184 ILE 184 184 184 ILE ILE B . n 
B 1 185 SER 185 185 185 SER SER B . n 
B 1 186 ILE 186 186 186 ILE ILE B . n 
B 1 187 GLY 187 187 187 GLY GLY B . n 
B 1 188 LEU 188 188 188 LEU LEU B . n 
B 1 189 VAL 189 189 189 VAL VAL B . n 
B 1 190 SER 190 190 190 SER SER B . n 
B 1 191 PHE 191 191 191 PHE PHE B . n 
B 1 192 GLY 192 192 192 GLY GLY B . n 
B 1 193 GLU 193 193 193 GLU GLU B . n 
B 1 194 HIS 194 194 194 HIS HIS B . n 
B 1 195 TYR 195 195 195 TYR TYR B . n 
B 1 196 LYS 196 196 196 LYS LYS B . n 
B 1 197 ARG 197 197 197 ARG ARG B . n 
B 1 198 ASN 198 198 198 ASN ASN B . n 
B 1 199 GLU 199 199 ?   ?   ?   B . n 
B 1 200 THR 200 200 ?   ?   ?   B . n 
B 1 201 GLY 201 201 ?   ?   ?   B . n 
B 1 202 LEU 202 202 ?   ?   ?   B . n 
B 1 203 SER 203 203 ?   ?   ?   B . n 
B 1 204 VAL 204 204 ?   ?   ?   B . n 
B 1 205 ALA 205 205 ?   ?   ?   B . n 
B 1 206 ALA 206 206 ?   ?   ?   B . n 
B 1 207 SER 207 207 ?   ?   ?   B . n 
B 1 208 SER 208 208 ?   ?   ?   B . n 
B 1 209 LEU 209 209 ?   ?   ?   B . n 
B 1 210 PHE 210 210 ?   ?   ?   B . n 
B 1 211 THR 211 211 ?   ?   ?   B . n 
B 1 212 SER 212 212 ?   ?   ?   B . n 
B 1 213 GLY 213 213 ?   ?   ?   B . n 
B 1 214 ARG 214 214 214 ARG ARG B . n 
B 1 215 PHE 215 215 215 PHE PHE B . n 
B 1 216 ALA 216 216 216 ALA ALA B . n 
B 1 217 ILE 217 217 217 ILE ILE B . n 
B 1 218 ASP 218 218 218 ASP ASP B . n 
B 1 219 PRO 219 219 219 PRO PRO B . n 
B 1 220 GLU 220 220 220 GLU GLU B . n 
B 1 221 LEU 221 221 221 LEU LEU B . n 
B 1 222 ARG 222 222 222 ARG ARG B . n 
B 1 223 GLY 223 223 223 GLY GLY B . n 
B 1 224 ALA 224 224 224 ALA ALA B . n 
B 1 225 GLU 225 225 225 GLU GLU B . n 
B 1 226 PHE 226 226 226 PHE PHE B . n 
B 1 227 GLU 227 227 227 GLU GLU B . n 
B 1 228 ARG 228 228 228 ARG ARG B . n 
B 1 229 ILE 229 229 229 ILE ILE B . n 
B 1 230 THR 230 230 230 THR THR B . n 
B 1 231 GLN 231 231 231 GLN GLN B . n 
B 1 232 ASN 232 232 232 ASN ASN B . n 
B 1 233 LEU 233 233 233 LEU LEU B . n 
B 1 234 ASP 234 234 234 ASP ASP B . n 
B 1 235 VAL 235 235 235 VAL VAL B . n 
B 1 236 HIS 236 236 236 HIS HIS B . n 
B 1 237 PHE 237 237 237 PHE PHE B . n 
B 1 238 TRP 238 238 238 TRP TRP B . n 
B 1 239 LYS 239 239 239 LYS LYS B . n 
B 1 240 ALA 240 240 240 ALA ALA B . n 
B 1 241 PHE 241 241 241 PHE PHE B . n 
B 1 242 TRP 242 242 242 TRP TRP B . n 
B 1 243 ASN 243 243 243 ASN ASN B . n 
B 1 244 ILE 244 244 244 ILE ILE B . n 
B 1 245 THR 245 245 245 THR THR B . n 
B 1 246 GLU 246 246 246 GLU GLU B . n 
B 1 247 MET 247 247 247 MET MET B . n 
B 1 248 GLU 248 248 248 GLU GLU B . n 
B 1 249 VAL 249 249 249 VAL VAL B . n 
B 1 250 LEU 250 250 250 LEU LEU B . n 
B 1 251 SER 251 251 251 SER SER B . n 
B 1 252 SER 252 252 252 SER SER B . n 
B 1 253 LEU 253 253 253 LEU LEU B . n 
B 1 254 ALA 254 254 254 ALA ALA B . n 
B 1 255 ASN 255 255 255 ASN ASN B . n 
B 1 256 MET 256 256 256 MET MET B . n 
B 1 257 ALA 257 257 257 ALA ALA B . n 
B 1 258 SER 258 258 258 SER SER B . n 
B 1 259 ALA 259 259 259 ALA ALA B . n 
B 1 260 THR 260 260 260 THR THR B . n 
B 1 261 VAL 261 261 261 VAL VAL B . n 
B 1 262 ARG 262 262 262 ARG ARG B . n 
B 1 263 VAL 263 263 263 VAL VAL B . n 
B 1 264 SER 264 264 264 SER SER B . n 
B 1 265 ARG 265 265 265 ARG ARG B . n 
B 1 266 LEU 266 266 266 LEU LEU B . n 
B 1 267 LEU 267 267 267 LEU LEU B . n 
B 1 268 SER 268 268 268 SER SER B . n 
B 1 269 LEU 269 269 269 LEU LEU B . n 
B 1 270 PRO 270 270 270 PRO PRO B . n 
B 1 271 PRO 271 271 271 PRO PRO B . n 
B 1 272 GLU 272 272 272 GLU GLU B . n 
B 1 273 ALA 273 273 273 ALA ALA B . n 
B 1 274 PHE 274 274 274 PHE PHE B . n 
B 1 275 GLU 275 275 275 GLU GLU B . n 
B 1 276 MET 276 276 276 MET MET B . n 
B 1 277 PRO 277 277 277 PRO PRO B . n 
B 1 278 LEU 278 278 278 LEU LEU B . n 
B 1 279 THR 279 279 279 THR THR B . n 
B 1 280 ALA 280 280 280 ALA ALA B . n 
B 1 281 ASP 281 281 281 ASP ASP B . n 
B 1 282 PRO 282 282 282 PRO PRO B . n 
B 1 283 THR 283 283 283 THR THR B . n 
B 1 284 LEU 284 284 284 LEU LEU B . n 
B 1 285 THR 285 285 285 THR THR B . n 
B 1 286 VAL 286 286 286 VAL VAL B . n 
B 1 287 THR 287 287 287 THR THR B . n 
B 1 288 ILE 288 288 288 ILE ILE B . n 
B 1 289 SER 289 289 289 SER SER B . n 
B 1 290 PRO 290 290 290 PRO PRO B . n 
B 1 291 PRO 291 291 291 PRO PRO B . n 
B 1 292 LEU 292 292 292 LEU LEU B . n 
B 1 293 ALA 293 293 293 ALA ALA B . n 
B 1 294 HIS 294 294 294 HIS HIS B . n 
B 1 295 THR 295 295 295 THR THR B . n 
B 1 296 GLY 296 296 296 GLY GLY B . n 
B 1 297 PRO 297 297 297 PRO PRO B . n 
B 1 298 GLY 298 298 298 GLY GLY B . n 
B 1 299 PRO 299 299 299 PRO PRO B . n 
B 1 300 VAL 300 300 300 VAL VAL B . n 
B 1 301 LEU 301 301 301 LEU LEU B . n 
B 1 302 VAL 302 302 302 VAL VAL B . n 
B 1 303 ARG 303 303 303 ARG ARG B . n 
B 1 304 LEU 304 304 304 LEU LEU B . n 
B 1 305 ILE 305 305 305 ILE ILE B . n 
B 1 306 SER 306 306 306 SER SER B . n 
B 1 307 TYR 307 307 307 TYR TYR B . n 
B 1 308 ASP 308 308 308 ASP ASP B . n 
B 1 309 LEU 309 309 309 LEU LEU B . n 
B 1 310 ARG 310 310 310 ARG ARG B . n 
B 1 311 GLU 311 311 311 GLU GLU B . n 
B 1 312 GLY 312 312 312 GLY GLY B . n 
B 1 313 GLN 313 313 313 GLN GLN B . n 
B 1 314 ASP 314 314 314 ASP ASP B . n 
B 1 315 SER 315 315 315 SER SER B . n 
B 1 316 GLU 316 316 316 GLU GLU B . n 
B 1 317 GLU 317 317 317 GLU GLU B . n 
B 1 318 LEU 318 318 318 LEU LEU B . n 
B 1 319 SER 319 319 319 SER SER B . n 
B 1 320 SER 320 320 320 SER SER B . n 
B 1 321 LEU 321 321 321 LEU LEU B . n 
B 1 322 ILE 322 322 322 ILE ILE B . n 
B 1 323 LYS 323 323 323 LYS LYS B . n 
B 1 324 SER 324 324 324 SER SER B . n 
B 1 325 ASN 325 325 ?   ?   ?   B . n 
B 1 326 GLY 326 326 ?   ?   ?   B . n 
B 1 327 GLN 327 327 ?   ?   ?   B . n 
B 1 328 ARG 328 328 ?   ?   ?   B . n 
B 1 329 SER 329 329 ?   ?   ?   B . n 
B 1 330 LEU 330 330 ?   ?   ?   B . n 
B 1 331 GLU 331 331 ?   ?   ?   B . n 
B 1 332 LEU 332 332 ?   ?   ?   B . n 
B 1 333 TRP 333 333 ?   ?   ?   B . n 
B 1 334 PRO 334 334 ?   ?   ?   B . n 
B 1 335 ARG 335 335 ?   ?   ?   B . n 
B 1 336 PRO 336 336 ?   ?   ?   B . n 
B 1 337 GLN 337 337 337 GLN GLN B . n 
B 1 338 GLN 338 338 338 GLN GLN B . n 
B 1 339 ALA 339 339 339 ALA ALA B . n 
B 1 340 PRO 340 340 340 PRO PRO B . n 
B 1 341 ARG 341 341 341 ARG ARG B . n 
B 1 342 SER 342 342 342 SER SER B . n 
B 1 343 ARG 343 343 343 ARG ARG B . n 
B 1 344 SER 344 344 344 SER SER B . n 
B 1 345 LEU 345 345 345 LEU LEU B . n 
B 1 346 ILE 346 346 346 ILE ILE B . n 
B 1 347 VAL 347 347 347 VAL VAL B . n 
B 1 348 HIS 348 348 348 HIS HIS B . n 
B 1 349 PHE 349 349 349 PHE PHE B . n 
B 1 350 HIS 350 350 350 HIS HIS B . n 
B 1 351 GLY 351 351 351 GLY GLY B . n 
B 1 352 GLY 352 352 352 GLY GLY B . n 
B 1 353 GLY 353 353 353 GLY GLY B . n 
B 1 354 PHE 354 354 354 PHE PHE B . n 
B 1 355 VAL 355 355 355 VAL VAL B . n 
B 1 356 ALA 356 356 356 ALA ALA B . n 
B 1 357 GLN 357 357 357 GLN GLN B . n 
B 1 358 THR 358 358 358 THR THR B . n 
B 1 359 SER 359 359 359 SER SER B . n 
B 1 360 ARG 360 360 360 ARG ARG B . n 
B 1 361 SER 361 361 361 SER SER B . n 
B 1 362 HIS 362 362 362 HIS HIS B . n 
B 1 363 GLU 363 363 363 GLU GLU B . n 
B 1 364 PRO 364 364 364 PRO PRO B . n 
B 1 365 TYR 365 365 365 TYR TYR B . n 
B 1 366 LEU 366 366 366 LEU LEU B . n 
B 1 367 LYS 367 367 367 LYS LYS B . n 
B 1 368 SER 368 368 368 SER SER B . n 
B 1 369 TRP 369 369 369 TRP TRP B . n 
B 1 370 ALA 370 370 370 ALA ALA B . n 
B 1 371 GLN 371 371 371 GLN GLN B . n 
B 1 372 GLU 372 372 372 GLU GLU B . n 
B 1 373 LEU 373 373 373 LEU LEU B . n 
B 1 374 GLY 374 374 374 GLY GLY B . n 
B 1 375 ALA 375 375 375 ALA ALA B . n 
B 1 376 PRO 376 376 376 PRO PRO B . n 
B 1 377 ILE 377 377 377 ILE ILE B . n 
B 1 378 ILE 378 378 378 ILE ILE B . n 
B 1 379 SER 379 379 379 SER SER B . n 
B 1 380 ILE 380 380 380 ILE ILE B . n 
B 1 381 ASP 381 381 381 ASP ASP B . n 
B 1 382 TYR 382 382 382 TYR TYR B . n 
B 1 383 SER 383 383 383 SER SER B . n 
B 1 384 LEU 384 384 384 LEU LEU B . n 
B 1 385 ALA 385 385 385 ALA ALA B . n 
B 1 386 PRO 386 386 386 PRO PRO B . n 
B 1 387 GLU 387 387 387 GLU GLU B . n 
B 1 388 ALA 388 388 388 ALA ALA B . n 
B 1 389 PRO 389 389 389 PRO PRO B . n 
B 1 390 PHE 390 390 390 PHE PHE B . n 
B 1 391 PRO 391 391 391 PRO PRO B . n 
B 1 392 ARG 392 392 392 ARG ARG B . n 
B 1 393 ALA 393 393 393 ALA ALA B . n 
B 1 394 LEU 394 394 394 LEU LEU B . n 
B 1 395 GLU 395 395 395 GLU GLU B . n 
B 1 396 GLU 396 396 396 GLU GLU B . n 
B 1 397 CYS 397 397 397 CYS CYS B . n 
B 1 398 PHE 398 398 398 PHE PHE B . n 
B 1 399 PHE 399 399 399 PHE PHE B . n 
B 1 400 ALA 400 400 400 ALA ALA B . n 
B 1 401 TYR 401 401 401 TYR TYR B . n 
B 1 402 CYS 402 402 402 CYS CYS B . n 
B 1 403 TRP 403 403 403 TRP TRP B . n 
B 1 404 ALA 404 404 404 ALA ALA B . n 
B 1 405 ILE 405 405 405 ILE ILE B . n 
B 1 406 LYS 406 406 406 LYS LYS B . n 
B 1 407 HIS 407 407 407 HIS HIS B . n 
B 1 408 CYS 408 408 408 CYS CYS B . n 
B 1 409 ALA 409 409 409 ALA ALA B . n 
B 1 410 LEU 410 410 410 LEU LEU B . n 
B 1 411 LEU 411 411 411 LEU LEU B . n 
B 1 412 GLY 412 412 412 GLY GLY B . n 
B 1 413 SER 413 413 413 SER SER B . n 
B 1 414 THR 414 414 414 THR THR B . n 
B 1 415 GLY 415 415 415 GLY GLY B . n 
B 1 416 GLU 416 416 416 GLU GLU B . n 
B 1 417 ARG 417 417 417 ARG ARG B . n 
B 1 418 ILE 418 418 418 ILE ILE B . n 
B 1 419 CYS 419 419 419 CYS CYS B . n 
B 1 420 LEU 420 420 420 LEU LEU B . n 
B 1 421 ALA 421 421 421 ALA ALA B . n 
B 1 422 GLY 422 422 422 GLY GLY B . n 
B 1 423 ASP 423 423 423 ASP ASP B . n 
B 1 424 SER 424 424 424 SER SER B . n 
B 1 425 ALA 425 425 425 ALA ALA B . n 
B 1 426 GLY 426 426 426 GLY GLY B . n 
B 1 427 GLY 427 427 427 GLY GLY B . n 
B 1 428 ASN 428 428 428 ASN ASN B . n 
B 1 429 LEU 429 429 429 LEU LEU B . n 
B 1 430 CYS 430 430 430 CYS CYS B . n 
B 1 431 PHE 431 431 431 PHE PHE B . n 
B 1 432 THR 432 432 432 THR THR B . n 
B 1 433 VAL 433 433 433 VAL VAL B . n 
B 1 434 ALA 434 434 434 ALA ALA B . n 
B 1 435 LEU 435 435 435 LEU LEU B . n 
B 1 436 ARG 436 436 436 ARG ARG B . n 
B 1 437 ALA 437 437 437 ALA ALA B . n 
B 1 438 ALA 438 438 438 ALA ALA B . n 
B 1 439 ALA 439 439 439 ALA ALA B . n 
B 1 440 TYR 440 440 440 TYR TYR B . n 
B 1 441 GLY 441 441 441 GLY GLY B . n 
B 1 442 VAL 442 442 442 VAL VAL B . n 
B 1 443 ARG 443 443 443 ARG ARG B . n 
B 1 444 VAL 444 444 444 VAL VAL B . n 
B 1 445 PRO 445 445 445 PRO PRO B . n 
B 1 446 ASP 446 446 446 ASP ASP B . n 
B 1 447 GLY 447 447 447 GLY GLY B . n 
B 1 448 ILE 448 448 448 ILE ILE B . n 
B 1 449 MET 449 449 449 MET MET B . n 
B 1 450 ALA 450 450 450 ALA ALA B . n 
B 1 451 ALA 451 451 451 ALA ALA B . n 
B 1 452 TYR 452 452 452 TYR TYR B . n 
B 1 453 PRO 453 453 453 PRO PRO B . n 
B 1 454 ALA 454 454 454 ALA ALA B . n 
B 1 455 THR 455 455 455 THR THR B . n 
B 1 456 MET 456 456 456 MET MET B . n 
B 1 457 LEU 457 457 457 LEU LEU B . n 
B 1 458 GLN 458 458 458 GLN GLN B . n 
B 1 459 PRO 459 459 459 PRO PRO B . n 
B 1 460 ALA 460 460 460 ALA ALA B . n 
B 1 461 ALA 461 461 461 ALA ALA B . n 
B 1 462 SER 462 462 462 SER SER B . n 
B 1 463 PRO 463 463 463 PRO PRO B . n 
B 1 464 SER 464 464 464 SER SER B . n 
B 1 465 ARG 465 465 465 ARG ARG B . n 
B 1 466 LEU 466 466 466 LEU LEU B . n 
B 1 467 LEU 467 467 467 LEU LEU B . n 
B 1 468 SER 468 468 468 SER SER B . n 
B 1 469 LEU 469 469 469 LEU LEU B . n 
B 1 470 MET 470 470 470 MET MET B . n 
B 1 471 ASP 471 471 471 ASP ASP B . n 
B 1 472 PRO 472 472 472 PRO PRO B . n 
B 1 473 LEU 473 473 473 LEU LEU B . n 
B 1 474 LEU 474 474 474 LEU LEU B . n 
B 1 475 PRO 475 475 475 PRO PRO B . n 
B 1 476 LEU 476 476 476 LEU LEU B . n 
B 1 477 SER 477 477 477 SER SER B . n 
B 1 478 VAL 478 478 478 VAL VAL B . n 
B 1 479 LEU 479 479 479 LEU LEU B . n 
B 1 480 SER 480 480 480 SER SER B . n 
B 1 481 LYS 481 481 481 LYS LYS B . n 
B 1 482 CYS 482 482 482 CYS CYS B . n 
B 1 483 VAL 483 483 483 VAL VAL B . n 
B 1 484 SER 484 484 484 SER SER B . n 
B 1 485 ALA 485 485 485 ALA ALA B . n 
B 1 486 TYR 486 486 486 TYR TYR B . n 
B 1 487 ALA 487 487 487 ALA ALA B . n 
B 1 488 GLY 488 488 488 GLY GLY B . n 
B 1 489 ALA 489 489 489 ALA ALA B . n 
B 1 490 LYS 490 490 490 LYS LYS B . n 
B 1 491 THR 491 491 491 THR THR B . n 
B 1 492 GLU 492 492 ?   ?   ?   B . n 
B 1 493 ASP 493 493 ?   ?   ?   B . n 
B 1 494 HIS 494 494 ?   ?   ?   B . n 
B 1 495 SER 495 495 ?   ?   ?   B . n 
B 1 496 ASN 496 496 ?   ?   ?   B . n 
B 1 497 SER 497 497 ?   ?   ?   B . n 
B 1 498 ASP 498 498 ?   ?   ?   B . n 
B 1 499 GLN 499 499 ?   ?   ?   B . n 
B 1 500 LYS 500 500 ?   ?   ?   B . n 
B 1 501 ALA 501 501 ?   ?   ?   B . n 
B 1 502 LEU 502 502 ?   ?   ?   B . n 
B 1 503 GLY 503 503 ?   ?   ?   B . n 
B 1 504 MET 504 504 ?   ?   ?   B . n 
B 1 505 MET 505 505 ?   ?   ?   B . n 
B 1 506 GLY 506 506 ?   ?   ?   B . n 
B 1 507 LEU 507 507 ?   ?   ?   B . n 
B 1 508 VAL 508 508 ?   ?   ?   B . n 
B 1 509 ARG 509 509 ?   ?   ?   B . n 
B 1 510 ARG 510 510 ?   ?   ?   B . n 
B 1 511 ASP 511 511 ?   ?   ?   B . n 
B 1 512 THR 512 512 ?   ?   ?   B . n 
B 1 513 ALA 513 513 ?   ?   ?   B . n 
B 1 514 LEU 514 514 ?   ?   ?   B . n 
B 1 515 LEU 515 515 ?   ?   ?   B . n 
B 1 516 LEU 516 516 ?   ?   ?   B . n 
B 1 517 ARG 517 517 ?   ?   ?   B . n 
B 1 518 ASP 518 518 ?   ?   ?   B . n 
B 1 519 PHE 519 519 ?   ?   ?   B . n 
B 1 520 ARG 520 520 ?   ?   ?   B . n 
B 1 521 LEU 521 521 ?   ?   ?   B . n 
B 1 522 GLY 522 522 ?   ?   ?   B . n 
B 1 523 ALA 523 523 ?   ?   ?   B . n 
B 1 524 SER 524 524 ?   ?   ?   B . n 
B 1 525 SER 525 525 ?   ?   ?   B . n 
B 1 526 TRP 526 526 ?   ?   ?   B . n 
B 1 527 LEU 527 527 ?   ?   ?   B . n 
B 1 528 ASN 528 528 ?   ?   ?   B . n 
B 1 529 SER 529 529 ?   ?   ?   B . n 
B 1 530 PHE 530 530 ?   ?   ?   B . n 
B 1 531 LEU 531 531 ?   ?   ?   B . n 
B 1 532 GLU 532 532 ?   ?   ?   B . n 
B 1 533 LEU 533 533 ?   ?   ?   B . n 
B 1 534 SER 534 534 ?   ?   ?   B . n 
B 1 535 GLY 535 535 ?   ?   ?   B . n 
B 1 536 ARG 536 536 ?   ?   ?   B . n 
B 1 537 LYS 537 537 ?   ?   ?   B . n 
B 1 538 SER 538 538 ?   ?   ?   B . n 
B 1 539 GLN 539 539 ?   ?   ?   B . n 
B 1 540 LYS 540 540 ?   ?   ?   B . n 
B 1 541 MET 541 541 ?   ?   ?   B . n 
B 1 542 SER 542 542 ?   ?   ?   B . n 
B 1 543 GLU 543 543 ?   ?   ?   B . n 
B 1 544 PRO 544 544 ?   ?   ?   B . n 
B 1 545 ILE 545 545 ?   ?   ?   B . n 
B 1 546 ALA 546 546 ?   ?   ?   B . n 
B 1 547 GLU 547 547 ?   ?   ?   B . n 
B 1 548 PRO 548 548 ?   ?   ?   B . n 
B 1 549 MET 549 549 ?   ?   ?   B . n 
B 1 550 ARG 550 550 ?   ?   ?   B . n 
B 1 551 ARG 551 551 ?   ?   ?   B . n 
B 1 552 SER 552 552 ?   ?   ?   B . n 
B 1 553 VAL 553 553 ?   ?   ?   B . n 
B 1 554 SER 554 554 ?   ?   ?   B . n 
B 1 555 GLU 555 555 ?   ?   ?   B . n 
B 1 556 ALA 556 556 ?   ?   ?   B . n 
B 1 557 ALA 557 557 ?   ?   ?   B . n 
B 1 558 LEU 558 558 ?   ?   ?   B . n 
B 1 559 ALA 559 559 ?   ?   ?   B . n 
B 1 560 GLN 560 560 ?   ?   ?   B . n 
B 1 561 PRO 561 561 ?   ?   ?   B . n 
B 1 562 GLN 562 562 ?   ?   ?   B . n 
B 1 563 GLY 563 563 ?   ?   ?   B . n 
B 1 564 PRO 564 564 ?   ?   ?   B . n 
B 1 565 LEU 565 565 ?   ?   ?   B . n 
B 1 566 GLY 566 566 ?   ?   ?   B . n 
B 1 567 THR 567 567 ?   ?   ?   B . n 
B 1 568 ASP 568 568 ?   ?   ?   B . n 
B 1 569 SER 569 569 ?   ?   ?   B . n 
B 1 570 LEU 570 570 ?   ?   ?   B . n 
B 1 571 LYS 571 571 ?   ?   ?   B . n 
B 1 572 ASN 572 572 ?   ?   ?   B . n 
B 1 573 LEU 573 573 ?   ?   ?   B . n 
B 1 574 THR 574 574 ?   ?   ?   B . n 
B 1 575 LEU 575 575 ?   ?   ?   B . n 
B 1 576 ARG 576 576 ?   ?   ?   B . n 
B 1 577 ASP 577 577 ?   ?   ?   B . n 
B 1 578 LEU 578 578 ?   ?   ?   B . n 
B 1 579 SER 579 579 ?   ?   ?   B . n 
B 1 580 LEU 580 580 ?   ?   ?   B . n 
B 1 581 ARG 581 581 ?   ?   ?   B . n 
B 1 582 GLY 582 582 ?   ?   ?   B . n 
B 1 583 ASN 583 583 ?   ?   ?   B . n 
B 1 584 SER 584 584 ?   ?   ?   B . n 
B 1 585 GLU 585 585 ?   ?   ?   B . n 
B 1 586 THR 586 586 ?   ?   ?   B . n 
B 1 587 SER 587 587 ?   ?   ?   B . n 
B 1 588 SER 588 588 ?   ?   ?   B . n 
B 1 589 ASP 589 589 ?   ?   ?   B . n 
B 1 590 THR 590 590 ?   ?   ?   B . n 
B 1 591 PRO 591 591 ?   ?   ?   B . n 
B 1 592 GLU 592 592 ?   ?   ?   B . n 
B 1 593 MET 593 593 ?   ?   ?   B . n 
B 1 594 SER 594 594 ?   ?   ?   B . n 
B 1 595 LEU 595 595 ?   ?   ?   B . n 
B 1 596 SER 596 596 ?   ?   ?   B . n 
B 1 597 ALA 597 597 ?   ?   ?   B . n 
B 1 598 GLU 598 598 ?   ?   ?   B . n 
B 1 599 THR 599 599 ?   ?   ?   B . n 
B 1 600 LEU 600 600 ?   ?   ?   B . n 
B 1 601 SER 601 601 ?   ?   ?   B . n 
B 1 602 PRO 602 602 ?   ?   ?   B . n 
B 1 603 SER 603 603 ?   ?   ?   B . n 
B 1 604 THR 604 604 ?   ?   ?   B . n 
B 1 605 PRO 605 605 ?   ?   ?   B . n 
B 1 606 SER 606 606 ?   ?   ?   B . n 
B 1 607 ASP 607 607 ?   ?   ?   B . n 
B 1 608 VAL 608 608 ?   ?   ?   B . n 
B 1 609 ASN 609 609 ?   ?   ?   B . n 
B 1 610 PHE 610 610 ?   ?   ?   B . n 
B 1 611 LEU 611 611 ?   ?   ?   B . n 
B 1 612 LEU 612 612 ?   ?   ?   B . n 
B 1 613 PRO 613 613 ?   ?   ?   B . n 
B 1 614 PRO 614 614 ?   ?   ?   B . n 
B 1 615 GLU 615 615 ?   ?   ?   B . n 
B 1 616 ASP 616 616 ?   ?   ?   B . n 
B 1 617 ALA 617 617 ?   ?   ?   B . n 
B 1 618 GLY 618 618 ?   ?   ?   B . n 
B 1 619 GLU 619 619 ?   ?   ?   B . n 
B 1 620 GLU 620 620 ?   ?   ?   B . n 
B 1 621 ALA 621 621 ?   ?   ?   B . n 
B 1 622 GLU 622 622 ?   ?   ?   B . n 
B 1 623 ALA 623 623 ?   ?   ?   B . n 
B 1 624 LYS 624 624 ?   ?   ?   B . n 
B 1 625 ASN 625 625 ?   ?   ?   B . n 
B 1 626 GLU 626 626 ?   ?   ?   B . n 
B 1 627 LEU 627 627 ?   ?   ?   B . n 
B 1 628 SER 628 628 ?   ?   ?   B . n 
B 1 629 PRO 629 629 ?   ?   ?   B . n 
B 1 630 MET 630 630 ?   ?   ?   B . n 
B 1 631 ASP 631 631 ?   ?   ?   B . n 
B 1 632 ARG 632 632 ?   ?   ?   B . n 
B 1 633 GLY 633 633 ?   ?   ?   B . n 
B 1 634 LEU 634 634 ?   ?   ?   B . n 
B 1 635 GLY 635 635 ?   ?   ?   B . n 
B 1 636 VAL 636 636 ?   ?   ?   B . n 
B 1 637 ARG 637 637 ?   ?   ?   B . n 
B 1 638 ALA 638 638 638 ALA ALA B . n 
B 1 639 ALA 639 639 639 ALA ALA B . n 
B 1 640 PHE 640 640 640 PHE PHE B . n 
B 1 641 PRO 641 641 641 PRO PRO B . n 
B 1 642 GLU 642 642 642 GLU GLU B . n 
B 1 643 GLY 643 643 643 GLY GLY B . n 
B 1 644 PHE 644 644 644 PHE PHE B . n 
B 1 645 HIS 645 645 645 HIS HIS B . n 
B 1 646 PRO 646 646 646 PRO PRO B . n 
B 1 647 ARG 647 647 647 ARG ARG B . n 
B 1 648 ARG 648 648 648 ARG ARG B . n 
B 1 649 SER 649 649 649 SER SER B . n 
B 1 650 SER 650 650 650 SER SER B . n 
B 1 651 GLN 651 651 651 GLN GLN B . n 
B 1 652 GLY 652 652 652 GLY GLY B . n 
B 1 653 ALA 653 653 653 ALA ALA B . n 
B 1 654 THR 654 654 654 THR THR B . n 
B 1 655 GLN 655 655 655 GLN GLN B . n 
B 1 656 MET 656 656 656 MET MET B . n 
B 1 657 PRO 657 657 657 PRO PRO B . n 
B 1 658 LEU 658 658 658 LEU LEU B . n 
B 1 659 TYR 659 659 659 TYR TYR B . n 
B 1 660 SER 660 660 660 SER SER B . n 
B 1 661 SER 661 661 661 SER SER B . n 
B 1 662 PRO 662 662 662 PRO PRO B . n 
B 1 663 ILE 663 663 663 ILE ILE B . n 
B 1 664 VAL 664 664 664 VAL VAL B . n 
B 1 665 LYS 665 665 665 LYS LYS B . n 
B 1 666 ASN 666 666 666 ASN ASN B . n 
B 1 667 PRO 667 667 667 PRO PRO B . n 
B 1 668 PHE 668 668 668 PHE PHE B . n 
B 1 669 MET 669 669 669 MET MET B . n 
B 1 670 SER 670 670 670 SER SER B . n 
B 1 671 PRO 671 671 671 PRO PRO B . n 
B 1 672 LEU 672 672 672 LEU LEU B . n 
B 1 673 LEU 673 673 673 LEU LEU B . n 
B 1 674 ALA 674 674 674 ALA ALA B . n 
B 1 675 PRO 675 675 675 PRO PRO B . n 
B 1 676 ASP 676 676 676 ASP ASP B . n 
B 1 677 SER 677 677 677 SER SER B . n 
B 1 678 MET 678 678 678 MET MET B . n 
B 1 679 LEU 679 679 679 LEU LEU B . n 
B 1 680 LYS 680 680 680 LYS LYS B . n 
B 1 681 SER 681 681 681 SER SER B . n 
B 1 682 LEU 682 682 682 LEU LEU B . n 
B 1 683 PRO 683 683 683 PRO PRO B . n 
B 1 684 PRO 684 684 684 PRO PRO B . n 
B 1 685 VAL 685 685 685 VAL VAL B . n 
B 1 686 HIS 686 686 686 HIS HIS B . n 
B 1 687 ILE 687 687 687 ILE ILE B . n 
B 1 688 VAL 688 688 688 VAL VAL B . n 
B 1 689 ALA 689 689 689 ALA ALA B . n 
B 1 690 CYS 690 690 690 CYS CYS B . n 
B 1 691 ALA 691 691 691 ALA ALA B . n 
B 1 692 LEU 692 692 692 LEU LEU B . n 
B 1 693 ASP 693 693 693 ASP ASP B . n 
B 1 694 PRO 694 694 694 PRO PRO B . n 
B 1 695 MET 695 695 695 MET MET B . n 
B 1 696 LEU 696 696 696 LEU LEU B . n 
B 1 697 ASP 697 697 697 ASP ASP B . n 
B 1 698 ASP 698 698 698 ASP ASP B . n 
B 1 699 SER 699 699 699 SER SER B . n 
B 1 700 VAL 700 700 700 VAL VAL B . n 
B 1 701 MET 701 701 701 MET MET B . n 
B 1 702 LEU 702 702 702 LEU LEU B . n 
B 1 703 ALA 703 703 703 ALA ALA B . n 
B 1 704 ARG 704 704 704 ARG ARG B . n 
B 1 705 ARG 705 705 705 ARG ARG B . n 
B 1 706 LEU 706 706 706 LEU LEU B . n 
B 1 707 ARG 707 707 707 ARG ARG B . n 
B 1 708 ASN 708 708 708 ASN ASN B . n 
B 1 709 LEU 709 709 709 LEU LEU B . n 
B 1 710 GLY 710 710 710 GLY GLY B . n 
B 1 711 GLN 711 711 711 GLN GLN B . n 
B 1 712 PRO 712 712 712 PRO PRO B . n 
B 1 713 VAL 713 713 713 VAL VAL B . n 
B 1 714 THR 714 714 714 THR THR B . n 
B 1 715 LEU 715 715 715 LEU LEU B . n 
B 1 716 ARG 716 716 716 ARG ARG B . n 
B 1 717 VAL 717 717 717 VAL VAL B . n 
B 1 718 VAL 718 718 718 VAL VAL B . n 
B 1 719 GLU 719 719 719 GLU GLU B . n 
B 1 720 ASP 720 720 720 ASP ASP B . n 
B 1 721 LEU 721 721 721 LEU LEU B . n 
B 1 722 PRO 722 722 722 PRO PRO B . n 
B 1 723 HIS 723 723 723 HIS HIS B . n 
B 1 724 GLY 724 724 724 GLY GLY B . n 
B 1 725 PHE 725 725 725 PHE PHE B . n 
B 1 726 LEU 726 726 726 LEU LEU B . n 
B 1 727 THR 727 727 727 THR THR B . n 
B 1 728 LEU 728 728 728 LEU LEU B . n 
B 1 729 ALA 729 729 729 ALA ALA B . n 
B 1 730 ALA 730 730 730 ALA ALA B . n 
B 1 731 LEU 731 731 731 LEU LEU B . n 
B 1 732 CYS 732 732 732 CYS CYS B . n 
B 1 733 ARG 733 733 733 ARG ARG B . n 
B 1 734 GLU 734 734 734 GLU GLU B . n 
B 1 735 THR 735 735 735 THR THR B . n 
B 1 736 ARG 736 736 736 ARG ARG B . n 
B 1 737 GLN 737 737 737 GLN GLN B . n 
B 1 738 ALA 738 738 738 ALA ALA B . n 
B 1 739 ALA 739 739 739 ALA ALA B . n 
B 1 740 GLU 740 740 740 GLU GLU B . n 
B 1 741 LEU 741 741 741 LEU LEU B . n 
B 1 742 CYS 742 742 742 CYS CYS B . n 
B 1 743 VAL 743 743 743 VAL VAL B . n 
B 1 744 GLU 744 744 744 GLU GLU B . n 
B 1 745 ARG 745 745 745 ARG ARG B . n 
B 1 746 ILE 746 746 746 ILE ILE B . n 
B 1 747 ARG 747 747 747 ARG ARG B . n 
B 1 748 LEU 748 748 748 LEU LEU B . n 
B 1 749 VAL 749 749 749 VAL VAL B . n 
B 1 750 LEU 750 750 750 LEU LEU B . n 
B 1 751 THR 751 751 751 THR THR B . n 
B 1 752 PRO 752 752 752 PRO PRO B . n 
B 1 753 PRO 753 753 ?   ?   ?   B . n 
B 1 754 ALA 754 754 ?   ?   ?   B . n 
B 1 755 GLY 755 755 ?   ?   ?   B . n 
B 1 756 ALA 756 756 ?   ?   ?   B . n 
B 1 757 GLY 757 757 ?   ?   ?   B . n 
B 1 758 PRO 758 758 ?   ?   ?   B . n 
B 1 759 SER 759 759 ?   ?   ?   B . n 
B 1 760 GLY 760 760 ?   ?   ?   B . n 
B 1 761 GLU 761 761 ?   ?   ?   B . n 
B 1 762 THR 762 762 ?   ?   ?   B . n 
B 1 763 GLY 763 763 ?   ?   ?   B . n 
B 1 764 ALA 764 764 ?   ?   ?   B . n 
B 1 765 ALA 765 765 ?   ?   ?   B . n 
B 1 766 GLY 766 766 ?   ?   ?   B . n 
B 1 767 VAL 767 767 ?   ?   ?   B . n 
B 1 768 ASP 768 768 ?   ?   ?   B . n 
B 1 769 GLY 769 769 ?   ?   ?   B . n 
B 1 770 GLY 770 770 ?   ?   ?   B . n 
B 1 771 CYS 771 771 ?   ?   ?   B . n 
B 1 772 GLY 772 772 ?   ?   ?   B . n 
B 1 773 GLY 773 773 ?   ?   ?   B . n 
B 1 774 ARG 774 774 ?   ?   ?   B . n 
B 1 775 HIS 775 775 ?   ?   ?   B . n 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZVQ 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     8ZVQ 
_struct.title                        'Cryo-EM Structure of Human Hormone-sensitive Lipase (HSL)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZVQ 
_struct_keywords.text            
'Lipid droplets, Lipolysis, Human hormone-sensitive lipase, Hydrolysis of diacylglycerol (DAG), HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    LIPS_HUMAN 
_struct_ref.pdbx_db_accession          Q05469 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTAR
CCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLH
KGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKA
FWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSS
LIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFA
YCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLS
KCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQ
PQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAF
PEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVED
LPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
;
_struct_ref.pdbx_align_begin           302 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZVQ A 1 ? 775 ? Q05469 302 ? 1076 ? 1 775 
2 1 8ZVQ B 1 ? 775 ? Q05469 302 ? 1076 ? 1 775 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  1  THR A 5   ? SER A 23  ? THR A 5   SER A 23  1 ? 19 
HELX_P HELX_P2  2  GLU A 28  ? PHE A 61  ? GLU A 28  PHE A 61  1 ? 34 
HELX_P HELX_P3  3  GLY A 71  ? ASN A 96  ? GLY A 71  ASN A 96  1 ? 26 
HELX_P HELX_P4  4  THR A 104 ? THR A 134 ? THR A 104 THR A 134 1 ? 31 
HELX_P HELX_P5  5  GLU A 146 ? THR A 158 ? GLU A 146 THR A 158 1 ? 13 
HELX_P HELX_P6  6  GLY A 162 ? TYR A 165 ? GLY A 162 TYR A 165 1 ? 4  
HELX_P HELX_P7  7  PRO A 175 ? ARG A 197 ? PRO A 175 ARG A 197 1 ? 23 
HELX_P HELX_P8  9  PRO A 219 ? ASN A 232 ? PRO A 219 ASN A 232 1 ? 14 
HELX_P HELX_P9  10 VAL A 235 ? GLU A 246 ? VAL A 235 GLU A 246 1 ? 12 
HELX_P HELX_P10 11 GLU A 248 ? MET A 256 ? GLU A 248 MET A 256 1 ? 9  
HELX_P HELX_P11 12 GLU A 316 ? LEU A 321 ? GLU A 316 LEU A 321 1 ? 6  
HELX_P HELX_P12 13 SER A 359 ? LEU A 373 ? SER A 359 LEU A 373 1 ? 15 
HELX_P HELX_P13 14 ARG A 392 ? LYS A 406 ? ARG A 392 LYS A 406 1 ? 15 
HELX_P HELX_P14 15 SER A 424 ? ALA A 439 ? SER A 424 ALA A 439 1 ? 16 
HELX_P HELX_P15 16 SER A 464 ? LEU A 469 ? SER A 464 LEU A 469 5 ? 6  
HELX_P HELX_P16 17 LEU A 476 ? TYR A 486 ? LEU A 476 TYR A 486 1 ? 11 
HELX_P HELX_P17 18 PRO A 662 ? LYS A 665 ? PRO A 662 LYS A 665 5 ? 4  
HELX_P HELX_P18 19 PRO A 671 ? LEU A 673 ? PRO A 671 LEU A 673 5 ? 3  
HELX_P HELX_P19 20 ASP A 676 ? SER A 681 ? ASP A 676 SER A 681 1 ? 6  
HELX_P HELX_P20 21 LEU A 696 ? ASN A 708 ? LEU A 696 ASN A 708 1 ? 13 
HELX_P HELX_P21 22 PHE A 725 ? LEU A 728 ? PHE A 725 LEU A 728 5 ? 4  
HELX_P HELX_P22 23 ARG A 733 ? LEU A 750 ? ARG A 733 LEU A 750 1 ? 18 
HELX_P HELX_P23 24 THR B 5   ? SER B 23  ? THR B 5   SER B 23  1 ? 19 
HELX_P HELX_P24 25 GLU B 28  ? PHE B 61  ? GLU B 28  PHE B 61  1 ? 34 
HELX_P HELX_P25 26 GLY B 71  ? ASN B 96  ? GLY B 71  ASN B 96  1 ? 26 
HELX_P HELX_P26 27 THR B 104 ? THR B 134 ? THR B 104 THR B 134 1 ? 31 
HELX_P HELX_P27 28 GLU B 146 ? THR B 158 ? GLU B 146 THR B 158 1 ? 13 
HELX_P HELX_P28 29 GLY B 162 ? TYR B 165 ? GLY B 162 TYR B 165 1 ? 4  
HELX_P HELX_P29 30 PRO B 175 ? ARG B 197 ? PRO B 175 ARG B 197 1 ? 23 
HELX_P HELX_P30 32 PRO B 219 ? ASN B 232 ? PRO B 219 ASN B 232 1 ? 14 
HELX_P HELX_P31 33 VAL B 235 ? GLU B 246 ? VAL B 235 GLU B 246 1 ? 12 
HELX_P HELX_P32 34 GLU B 248 ? MET B 256 ? GLU B 248 MET B 256 1 ? 9  
HELX_P HELX_P33 35 GLU B 316 ? LEU B 321 ? GLU B 316 LEU B 321 1 ? 6  
HELX_P HELX_P34 36 SER B 359 ? LEU B 373 ? SER B 359 LEU B 373 1 ? 15 
HELX_P HELX_P35 37 ARG B 392 ? LYS B 406 ? ARG B 392 LYS B 406 1 ? 15 
HELX_P HELX_P36 38 SER B 424 ? ALA B 439 ? SER B 424 ALA B 439 1 ? 16 
HELX_P HELX_P37 39 SER B 464 ? LEU B 469 ? SER B 464 LEU B 469 5 ? 6  
HELX_P HELX_P38 40 LEU B 476 ? TYR B 486 ? LEU B 476 TYR B 486 1 ? 11 
HELX_P HELX_P39 41 PRO B 662 ? LYS B 665 ? PRO B 662 LYS B 665 5 ? 4  
HELX_P HELX_P40 42 PRO B 671 ? LEU B 673 ? PRO B 671 LEU B 673 5 ? 3  
HELX_P HELX_P41 43 ASP B 676 ? SER B 681 ? ASP B 676 SER B 681 1 ? 6  
HELX_P HELX_P42 44 LEU B 696 ? ASN B 708 ? LEU B 696 ASN B 708 1 ? 13 
HELX_P HELX_P43 45 PHE B 725 ? LEU B 728 ? PHE B 725 LEU B 728 5 ? 4  
HELX_P HELX_P44 46 ARG B 733 ? LEU B 750 ? ARG B 733 LEU B 750 1 ? 18 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 ALA 385 A . ? ALA 385 A PRO 386 A ? PRO 386 A 1 -0.38 
2 PHE 390 A . ? PHE 390 A PRO 391 A ? PRO 391 A 1 2.80  
3 ALA 385 B . ? ALA 385 B PRO 386 B ? PRO 386 B 1 2.30  
4 PHE 390 B . ? PHE 390 B PRO 391 B ? PRO 391 B 1 2.75  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
A ? 2 ? 
B ? 2 ? 
C ? 4 ? 
D ? 2 ? 
E ? 2 ? 
F ? 2 ? 
G ? 4 ? 
H ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
A 1 2 ? anti-parallel 
B 1 2 ? anti-parallel 
C 1 2 ? parallel      
C 2 3 ? parallel      
C 3 4 ? parallel      
D 1 2 ? parallel      
E 1 2 ? anti-parallel 
F 1 2 ? anti-parallel 
G 1 2 ? parallel      
G 2 3 ? parallel      
G 3 4 ? parallel      
H 1 2 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
A 1 VAL A 263 ? LEU A 269 ? VAL A 263 LEU A 269 
A 2 VAL A 300 ? SER A 306 ? VAL A 300 SER A 306 
B 1 PHE A 274 ? PRO A 277 ? PHE A 274 PRO A 277 
B 2 THR A 285 ? ILE A 288 ? THR A 285 ILE A 288 
C 1 PRO A 376 ? ILE A 380 ? PRO A 376 ILE A 380 
C 2 SER A 344 ? PHE A 349 ? SER A 344 PHE A 349 
C 3 ARG A 417 ? ASP A 423 ? ARG A 417 ASP A 423 
C 4 GLY A 447 ? ALA A 451 ? GLY A 447 ALA A 451 
D 1 VAL A 685 ? CYS A 690 ? VAL A 685 CYS A 690 
D 2 VAL A 713 ? VAL A 718 ? VAL A 713 VAL A 718 
E 1 VAL B 263 ? LEU B 269 ? VAL B 263 LEU B 269 
E 2 VAL B 300 ? SER B 306 ? VAL B 300 SER B 306 
F 1 PHE B 274 ? PRO B 277 ? PHE B 274 PRO B 277 
F 2 THR B 285 ? ILE B 288 ? THR B 285 ILE B 288 
G 1 PRO B 376 ? ILE B 380 ? PRO B 376 ILE B 380 
G 2 SER B 344 ? PHE B 349 ? SER B 344 PHE B 349 
G 3 ARG B 417 ? ASP B 423 ? ARG B 417 ASP B 423 
G 4 GLY B 447 ? ALA B 451 ? GLY B 447 ALA B 451 
H 1 VAL B 685 ? CYS B 690 ? VAL B 685 CYS B 690 
H 2 VAL B 713 ? VAL B 718 ? VAL B 713 VAL B 718 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
A 1 2 O VAL A 263 ? O VAL A 263 N SER A 306 ? N SER A 306 
B 1 2 O PHE A 274 ? O PHE A 274 N ILE A 288 ? N ILE A 288 
C 1 2 O PRO A 376 ? O PRO A 376 N ILE A 346 ? N ILE A 346 
C 2 3 O LEU A 345 ? O LEU A 345 N ARG A 417 ? N ARG A 417 
C 3 4 O LEU A 420 ? O LEU A 420 N GLY A 447 ? N GLY A 447 
D 1 2 O VAL A 685 ? O VAL A 685 N THR A 714 ? N THR A 714 
E 1 2 O VAL B 263 ? O VAL B 263 N SER B 306 ? N SER B 306 
F 1 2 O PHE B 274 ? O PHE B 274 N ILE B 288 ? N ILE B 288 
G 1 2 O PRO B 376 ? O PRO B 376 N ILE B 346 ? N ILE B 346 
G 2 3 O LEU B 345 ? O LEU B 345 N ARG B 417 ? N ARG B 417 
G 3 4 O LEU B 420 ? O LEU B 420 N GLY B 447 ? N GLY B 447 
H 1 2 O VAL B 685 ? O VAL B 685 N THR B 714 ? N THR B 714 
# 
_pdbx_entry_details.entry_id                   8ZVQ 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A ARG 178 ? ? NE2 A GLN 182 ? ? 1.53 
2 1 NH1 A ARG 262 ? ? O   A TYR 307 ? ? 1.60 
3 1 O   A ARG 178 ? ? CD  A GLN 182 ? ? 1.70 
4 1 CA  A PRO 179 ? ? OE1 A GLN 182 ? ? 1.78 
5 1 C   A ARG 178 ? ? NE2 A GLN 182 ? ? 1.81 
6 1 O   A ARG 178 ? ? OE1 A GLN 182 ? ? 1.87 
7 1 C   A PRO 179 ? ? OE1 A GLN 182 ? ? 2.01 
8 1 O   A PRO 179 ? ? OE1 A GLN 182 ? ? 2.17 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CA A LEU 728 ? ? CB A LEU 728 ? ? CG  A LEU 728 ? ? 132.48 115.30 17.18  2.30 N 
2 1 C  A THR 751 ? ? N  A PRO 752 ? ? CA  A PRO 752 ? ? 129.19 119.30 9.89   1.50 Y 
3 1 N  A PRO 752 ? ? CD A PRO 752 ? ? CG  A PRO 752 ? ? 92.85  103.20 -10.35 1.50 N 
4 1 CA B LEU 140 ? ? CB B LEU 140 ? ? CG  B LEU 140 ? ? 129.35 115.30 14.05  2.30 N 
5 1 CB B LEU 140 ? ? CG B LEU 140 ? ? CD2 B LEU 140 ? ? 100.68 111.00 -10.32 1.70 N 
6 1 CA B LEU 188 ? ? CB B LEU 188 ? ? CG  B LEU 188 ? ? 134.04 115.30 18.74  2.30 N 
7 1 CA B LEU 474 ? ? CB B LEU 474 ? ? CG  B LEU 474 ? ? 129.65 115.30 14.35  2.30 N 
8 1 CA B LEU 728 ? ? CB B LEU 728 ? ? CG  B LEU 728 ? ? 136.81 115.30 21.51  2.30 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 CYS A 168 ? ? -89.80  30.52   
2  1 ARG A 262 ? ? -130.92 -37.40  
3  1 PRO A 340 ? ? -77.25  -167.45 
4  1 PHE A 354 ? ? 56.55   13.74   
5  1 HIS A 407 ? ? -93.07  54.11   
6  1 TYR A 452 ? ? 37.41   68.72   
7  1 LEU A 467 ? ? -91.36  47.12   
8  1 PRO A 662 ? ? -58.10  -5.01   
9  1 LEU A 728 ? ? -140.98 27.86   
10 1 LEU A 731 ? ? -130.49 -36.26  
11 1 ARG B 262 ? ? -130.50 -32.29  
12 1 HIS B 294 ? ? 39.59   40.08   
13 1 TYR B 452 ? ? 39.54   70.64   
14 1 LEU B 467 ? ? -89.01  44.56   
15 1 MET B 695 ? ? -86.73  48.51   
16 1 ALA B 730 ? ? -95.73  34.74   
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     417 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.076 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8ZVQ 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8ZVQ 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.4 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               384309 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            8.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Human Hormone-sensitive Lipase (HSL)' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8ZVQ 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1500 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8ZVQ 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8ZVQ 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A ASP 2   ? A ASP 2   
3   1 Y 1 A LEU 3   ? A LEU 3   
4   1 Y 1 A GLU 199 ? A GLU 199 
5   1 Y 1 A THR 200 ? A THR 200 
6   1 Y 1 A GLY 201 ? A GLY 201 
7   1 Y 1 A LEU 202 ? A LEU 202 
8   1 Y 1 A SER 203 ? A SER 203 
9   1 Y 1 A VAL 204 ? A VAL 204 
10  1 Y 1 A ALA 205 ? A ALA 205 
11  1 Y 1 A ALA 206 ? A ALA 206 
12  1 Y 1 A SER 207 ? A SER 207 
13  1 Y 1 A SER 208 ? A SER 208 
14  1 Y 1 A LEU 209 ? A LEU 209 
15  1 Y 1 A PHE 210 ? A PHE 210 
16  1 Y 1 A THR 211 ? A THR 211 
17  1 Y 1 A SER 212 ? A SER 212 
18  1 Y 1 A GLY 213 ? A GLY 213 
19  1 Y 1 A ASN 325 ? A ASN 325 
20  1 Y 1 A GLY 326 ? A GLY 326 
21  1 Y 1 A GLN 327 ? A GLN 327 
22  1 Y 1 A ARG 328 ? A ARG 328 
23  1 Y 1 A SER 329 ? A SER 329 
24  1 Y 1 A LEU 330 ? A LEU 330 
25  1 Y 1 A GLU 331 ? A GLU 331 
26  1 Y 1 A LEU 332 ? A LEU 332 
27  1 Y 1 A TRP 333 ? A TRP 333 
28  1 Y 1 A PRO 334 ? A PRO 334 
29  1 Y 1 A ARG 335 ? A ARG 335 
30  1 Y 1 A PRO 336 ? A PRO 336 
31  1 Y 1 A GLU 492 ? A GLU 492 
32  1 Y 1 A ASP 493 ? A ASP 493 
33  1 Y 1 A HIS 494 ? A HIS 494 
34  1 Y 1 A SER 495 ? A SER 495 
35  1 Y 1 A ASN 496 ? A ASN 496 
36  1 Y 1 A SER 497 ? A SER 497 
37  1 Y 1 A ASP 498 ? A ASP 498 
38  1 Y 1 A GLN 499 ? A GLN 499 
39  1 Y 1 A LYS 500 ? A LYS 500 
40  1 Y 1 A ALA 501 ? A ALA 501 
41  1 Y 1 A LEU 502 ? A LEU 502 
42  1 Y 1 A GLY 503 ? A GLY 503 
43  1 Y 1 A MET 504 ? A MET 504 
44  1 Y 1 A MET 505 ? A MET 505 
45  1 Y 1 A GLY 506 ? A GLY 506 
46  1 Y 1 A LEU 507 ? A LEU 507 
47  1 Y 1 A VAL 508 ? A VAL 508 
48  1 Y 1 A ARG 509 ? A ARG 509 
49  1 Y 1 A ARG 510 ? A ARG 510 
50  1 Y 1 A ASP 511 ? A ASP 511 
51  1 Y 1 A THR 512 ? A THR 512 
52  1 Y 1 A ALA 513 ? A ALA 513 
53  1 Y 1 A LEU 514 ? A LEU 514 
54  1 Y 1 A LEU 515 ? A LEU 515 
55  1 Y 1 A LEU 516 ? A LEU 516 
56  1 Y 1 A ARG 517 ? A ARG 517 
57  1 Y 1 A ASP 518 ? A ASP 518 
58  1 Y 1 A PHE 519 ? A PHE 519 
59  1 Y 1 A ARG 520 ? A ARG 520 
60  1 Y 1 A LEU 521 ? A LEU 521 
61  1 Y 1 A GLY 522 ? A GLY 522 
62  1 Y 1 A ALA 523 ? A ALA 523 
63  1 Y 1 A SER 524 ? A SER 524 
64  1 Y 1 A SER 525 ? A SER 525 
65  1 Y 1 A TRP 526 ? A TRP 526 
66  1 Y 1 A LEU 527 ? A LEU 527 
67  1 Y 1 A ASN 528 ? A ASN 528 
68  1 Y 1 A SER 529 ? A SER 529 
69  1 Y 1 A PHE 530 ? A PHE 530 
70  1 Y 1 A LEU 531 ? A LEU 531 
71  1 Y 1 A GLU 532 ? A GLU 532 
72  1 Y 1 A LEU 533 ? A LEU 533 
73  1 Y 1 A SER 534 ? A SER 534 
74  1 Y 1 A GLY 535 ? A GLY 535 
75  1 Y 1 A ARG 536 ? A ARG 536 
76  1 Y 1 A LYS 537 ? A LYS 537 
77  1 Y 1 A SER 538 ? A SER 538 
78  1 Y 1 A GLN 539 ? A GLN 539 
79  1 Y 1 A LYS 540 ? A LYS 540 
80  1 Y 1 A MET 541 ? A MET 541 
81  1 Y 1 A SER 542 ? A SER 542 
82  1 Y 1 A GLU 543 ? A GLU 543 
83  1 Y 1 A PRO 544 ? A PRO 544 
84  1 Y 1 A ILE 545 ? A ILE 545 
85  1 Y 1 A ALA 546 ? A ALA 546 
86  1 Y 1 A GLU 547 ? A GLU 547 
87  1 Y 1 A PRO 548 ? A PRO 548 
88  1 Y 1 A MET 549 ? A MET 549 
89  1 Y 1 A ARG 550 ? A ARG 550 
90  1 Y 1 A ARG 551 ? A ARG 551 
91  1 Y 1 A SER 552 ? A SER 552 
92  1 Y 1 A VAL 553 ? A VAL 553 
93  1 Y 1 A SER 554 ? A SER 554 
94  1 Y 1 A GLU 555 ? A GLU 555 
95  1 Y 1 A ALA 556 ? A ALA 556 
96  1 Y 1 A ALA 557 ? A ALA 557 
97  1 Y 1 A LEU 558 ? A LEU 558 
98  1 Y 1 A ALA 559 ? A ALA 559 
99  1 Y 1 A GLN 560 ? A GLN 560 
100 1 Y 1 A PRO 561 ? A PRO 561 
101 1 Y 1 A GLN 562 ? A GLN 562 
102 1 Y 1 A GLY 563 ? A GLY 563 
103 1 Y 1 A PRO 564 ? A PRO 564 
104 1 Y 1 A LEU 565 ? A LEU 565 
105 1 Y 1 A GLY 566 ? A GLY 566 
106 1 Y 1 A THR 567 ? A THR 567 
107 1 Y 1 A ASP 568 ? A ASP 568 
108 1 Y 1 A SER 569 ? A SER 569 
109 1 Y 1 A LEU 570 ? A LEU 570 
110 1 Y 1 A LYS 571 ? A LYS 571 
111 1 Y 1 A ASN 572 ? A ASN 572 
112 1 Y 1 A LEU 573 ? A LEU 573 
113 1 Y 1 A THR 574 ? A THR 574 
114 1 Y 1 A LEU 575 ? A LEU 575 
115 1 Y 1 A ARG 576 ? A ARG 576 
116 1 Y 1 A ASP 577 ? A ASP 577 
117 1 Y 1 A LEU 578 ? A LEU 578 
118 1 Y 1 A SER 579 ? A SER 579 
119 1 Y 1 A LEU 580 ? A LEU 580 
120 1 Y 1 A ARG 581 ? A ARG 581 
121 1 Y 1 A GLY 582 ? A GLY 582 
122 1 Y 1 A ASN 583 ? A ASN 583 
123 1 Y 1 A SER 584 ? A SER 584 
124 1 Y 1 A GLU 585 ? A GLU 585 
125 1 Y 1 A THR 586 ? A THR 586 
126 1 Y 1 A SER 587 ? A SER 587 
127 1 Y 1 A SER 588 ? A SER 588 
128 1 Y 1 A ASP 589 ? A ASP 589 
129 1 Y 1 A THR 590 ? A THR 590 
130 1 Y 1 A PRO 591 ? A PRO 591 
131 1 Y 1 A GLU 592 ? A GLU 592 
132 1 Y 1 A MET 593 ? A MET 593 
133 1 Y 1 A SER 594 ? A SER 594 
134 1 Y 1 A LEU 595 ? A LEU 595 
135 1 Y 1 A SER 596 ? A SER 596 
136 1 Y 1 A ALA 597 ? A ALA 597 
137 1 Y 1 A GLU 598 ? A GLU 598 
138 1 Y 1 A THR 599 ? A THR 599 
139 1 Y 1 A LEU 600 ? A LEU 600 
140 1 Y 1 A SER 601 ? A SER 601 
141 1 Y 1 A PRO 602 ? A PRO 602 
142 1 Y 1 A SER 603 ? A SER 603 
143 1 Y 1 A THR 604 ? A THR 604 
144 1 Y 1 A PRO 605 ? A PRO 605 
145 1 Y 1 A SER 606 ? A SER 606 
146 1 Y 1 A ASP 607 ? A ASP 607 
147 1 Y 1 A VAL 608 ? A VAL 608 
148 1 Y 1 A ASN 609 ? A ASN 609 
149 1 Y 1 A PHE 610 ? A PHE 610 
150 1 Y 1 A LEU 611 ? A LEU 611 
151 1 Y 1 A LEU 612 ? A LEU 612 
152 1 Y 1 A PRO 613 ? A PRO 613 
153 1 Y 1 A PRO 614 ? A PRO 614 
154 1 Y 1 A GLU 615 ? A GLU 615 
155 1 Y 1 A ASP 616 ? A ASP 616 
156 1 Y 1 A ALA 617 ? A ALA 617 
157 1 Y 1 A GLY 618 ? A GLY 618 
158 1 Y 1 A GLU 619 ? A GLU 619 
159 1 Y 1 A GLU 620 ? A GLU 620 
160 1 Y 1 A ALA 621 ? A ALA 621 
161 1 Y 1 A GLU 622 ? A GLU 622 
162 1 Y 1 A ALA 623 ? A ALA 623 
163 1 Y 1 A LYS 624 ? A LYS 624 
164 1 Y 1 A ASN 625 ? A ASN 625 
165 1 Y 1 A GLU 626 ? A GLU 626 
166 1 Y 1 A LEU 627 ? A LEU 627 
167 1 Y 1 A SER 628 ? A SER 628 
168 1 Y 1 A PRO 629 ? A PRO 629 
169 1 Y 1 A MET 630 ? A MET 630 
170 1 Y 1 A ASP 631 ? A ASP 631 
171 1 Y 1 A ARG 632 ? A ARG 632 
172 1 Y 1 A GLY 633 ? A GLY 633 
173 1 Y 1 A LEU 634 ? A LEU 634 
174 1 Y 1 A GLY 635 ? A GLY 635 
175 1 Y 1 A VAL 636 ? A VAL 636 
176 1 Y 1 A ARG 637 ? A ARG 637 
177 1 Y 1 A PRO 753 ? A PRO 753 
178 1 Y 1 A ALA 754 ? A ALA 754 
179 1 Y 1 A GLY 755 ? A GLY 755 
180 1 Y 1 A ALA 756 ? A ALA 756 
181 1 Y 1 A GLY 757 ? A GLY 757 
182 1 Y 1 A PRO 758 ? A PRO 758 
183 1 Y 1 A SER 759 ? A SER 759 
184 1 Y 1 A GLY 760 ? A GLY 760 
185 1 Y 1 A GLU 761 ? A GLU 761 
186 1 Y 1 A THR 762 ? A THR 762 
187 1 Y 1 A GLY 763 ? A GLY 763 
188 1 Y 1 A ALA 764 ? A ALA 764 
189 1 Y 1 A ALA 765 ? A ALA 765 
190 1 Y 1 A GLY 766 ? A GLY 766 
191 1 Y 1 A VAL 767 ? A VAL 767 
192 1 Y 1 A ASP 768 ? A ASP 768 
193 1 Y 1 A GLY 769 ? A GLY 769 
194 1 Y 1 A GLY 770 ? A GLY 770 
195 1 Y 1 A CYS 771 ? A CYS 771 
196 1 Y 1 A GLY 772 ? A GLY 772 
197 1 Y 1 A GLY 773 ? A GLY 773 
198 1 Y 1 A ARG 774 ? A ARG 774 
199 1 Y 1 A HIS 775 ? A HIS 775 
200 1 Y 1 B MET 1   ? B MET 1   
201 1 Y 1 B ASP 2   ? B ASP 2   
202 1 Y 1 B LEU 3   ? B LEU 3   
203 1 Y 1 B GLU 199 ? B GLU 199 
204 1 Y 1 B THR 200 ? B THR 200 
205 1 Y 1 B GLY 201 ? B GLY 201 
206 1 Y 1 B LEU 202 ? B LEU 202 
207 1 Y 1 B SER 203 ? B SER 203 
208 1 Y 1 B VAL 204 ? B VAL 204 
209 1 Y 1 B ALA 205 ? B ALA 205 
210 1 Y 1 B ALA 206 ? B ALA 206 
211 1 Y 1 B SER 207 ? B SER 207 
212 1 Y 1 B SER 208 ? B SER 208 
213 1 Y 1 B LEU 209 ? B LEU 209 
214 1 Y 1 B PHE 210 ? B PHE 210 
215 1 Y 1 B THR 211 ? B THR 211 
216 1 Y 1 B SER 212 ? B SER 212 
217 1 Y 1 B GLY 213 ? B GLY 213 
218 1 Y 1 B ASN 325 ? B ASN 325 
219 1 Y 1 B GLY 326 ? B GLY 326 
220 1 Y 1 B GLN 327 ? B GLN 327 
221 1 Y 1 B ARG 328 ? B ARG 328 
222 1 Y 1 B SER 329 ? B SER 329 
223 1 Y 1 B LEU 330 ? B LEU 330 
224 1 Y 1 B GLU 331 ? B GLU 331 
225 1 Y 1 B LEU 332 ? B LEU 332 
226 1 Y 1 B TRP 333 ? B TRP 333 
227 1 Y 1 B PRO 334 ? B PRO 334 
228 1 Y 1 B ARG 335 ? B ARG 335 
229 1 Y 1 B PRO 336 ? B PRO 336 
230 1 Y 1 B GLU 492 ? B GLU 492 
231 1 Y 1 B ASP 493 ? B ASP 493 
232 1 Y 1 B HIS 494 ? B HIS 494 
233 1 Y 1 B SER 495 ? B SER 495 
234 1 Y 1 B ASN 496 ? B ASN 496 
235 1 Y 1 B SER 497 ? B SER 497 
236 1 Y 1 B ASP 498 ? B ASP 498 
237 1 Y 1 B GLN 499 ? B GLN 499 
238 1 Y 1 B LYS 500 ? B LYS 500 
239 1 Y 1 B ALA 501 ? B ALA 501 
240 1 Y 1 B LEU 502 ? B LEU 502 
241 1 Y 1 B GLY 503 ? B GLY 503 
242 1 Y 1 B MET 504 ? B MET 504 
243 1 Y 1 B MET 505 ? B MET 505 
244 1 Y 1 B GLY 506 ? B GLY 506 
245 1 Y 1 B LEU 507 ? B LEU 507 
246 1 Y 1 B VAL 508 ? B VAL 508 
247 1 Y 1 B ARG 509 ? B ARG 509 
248 1 Y 1 B ARG 510 ? B ARG 510 
249 1 Y 1 B ASP 511 ? B ASP 511 
250 1 Y 1 B THR 512 ? B THR 512 
251 1 Y 1 B ALA 513 ? B ALA 513 
252 1 Y 1 B LEU 514 ? B LEU 514 
253 1 Y 1 B LEU 515 ? B LEU 515 
254 1 Y 1 B LEU 516 ? B LEU 516 
255 1 Y 1 B ARG 517 ? B ARG 517 
256 1 Y 1 B ASP 518 ? B ASP 518 
257 1 Y 1 B PHE 519 ? B PHE 519 
258 1 Y 1 B ARG 520 ? B ARG 520 
259 1 Y 1 B LEU 521 ? B LEU 521 
260 1 Y 1 B GLY 522 ? B GLY 522 
261 1 Y 1 B ALA 523 ? B ALA 523 
262 1 Y 1 B SER 524 ? B SER 524 
263 1 Y 1 B SER 525 ? B SER 525 
264 1 Y 1 B TRP 526 ? B TRP 526 
265 1 Y 1 B LEU 527 ? B LEU 527 
266 1 Y 1 B ASN 528 ? B ASN 528 
267 1 Y 1 B SER 529 ? B SER 529 
268 1 Y 1 B PHE 530 ? B PHE 530 
269 1 Y 1 B LEU 531 ? B LEU 531 
270 1 Y 1 B GLU 532 ? B GLU 532 
271 1 Y 1 B LEU 533 ? B LEU 533 
272 1 Y 1 B SER 534 ? B SER 534 
273 1 Y 1 B GLY 535 ? B GLY 535 
274 1 Y 1 B ARG 536 ? B ARG 536 
275 1 Y 1 B LYS 537 ? B LYS 537 
276 1 Y 1 B SER 538 ? B SER 538 
277 1 Y 1 B GLN 539 ? B GLN 539 
278 1 Y 1 B LYS 540 ? B LYS 540 
279 1 Y 1 B MET 541 ? B MET 541 
280 1 Y 1 B SER 542 ? B SER 542 
281 1 Y 1 B GLU 543 ? B GLU 543 
282 1 Y 1 B PRO 544 ? B PRO 544 
283 1 Y 1 B ILE 545 ? B ILE 545 
284 1 Y 1 B ALA 546 ? B ALA 546 
285 1 Y 1 B GLU 547 ? B GLU 547 
286 1 Y 1 B PRO 548 ? B PRO 548 
287 1 Y 1 B MET 549 ? B MET 549 
288 1 Y 1 B ARG 550 ? B ARG 550 
289 1 Y 1 B ARG 551 ? B ARG 551 
290 1 Y 1 B SER 552 ? B SER 552 
291 1 Y 1 B VAL 553 ? B VAL 553 
292 1 Y 1 B SER 554 ? B SER 554 
293 1 Y 1 B GLU 555 ? B GLU 555 
294 1 Y 1 B ALA 556 ? B ALA 556 
295 1 Y 1 B ALA 557 ? B ALA 557 
296 1 Y 1 B LEU 558 ? B LEU 558 
297 1 Y 1 B ALA 559 ? B ALA 559 
298 1 Y 1 B GLN 560 ? B GLN 560 
299 1 Y 1 B PRO 561 ? B PRO 561 
300 1 Y 1 B GLN 562 ? B GLN 562 
301 1 Y 1 B GLY 563 ? B GLY 563 
302 1 Y 1 B PRO 564 ? B PRO 564 
303 1 Y 1 B LEU 565 ? B LEU 565 
304 1 Y 1 B GLY 566 ? B GLY 566 
305 1 Y 1 B THR 567 ? B THR 567 
306 1 Y 1 B ASP 568 ? B ASP 568 
307 1 Y 1 B SER 569 ? B SER 569 
308 1 Y 1 B LEU 570 ? B LEU 570 
309 1 Y 1 B LYS 571 ? B LYS 571 
310 1 Y 1 B ASN 572 ? B ASN 572 
311 1 Y 1 B LEU 573 ? B LEU 573 
312 1 Y 1 B THR 574 ? B THR 574 
313 1 Y 1 B LEU 575 ? B LEU 575 
314 1 Y 1 B ARG 576 ? B ARG 576 
315 1 Y 1 B ASP 577 ? B ASP 577 
316 1 Y 1 B LEU 578 ? B LEU 578 
317 1 Y 1 B SER 579 ? B SER 579 
318 1 Y 1 B LEU 580 ? B LEU 580 
319 1 Y 1 B ARG 581 ? B ARG 581 
320 1 Y 1 B GLY 582 ? B GLY 582 
321 1 Y 1 B ASN 583 ? B ASN 583 
322 1 Y 1 B SER 584 ? B SER 584 
323 1 Y 1 B GLU 585 ? B GLU 585 
324 1 Y 1 B THR 586 ? B THR 586 
325 1 Y 1 B SER 587 ? B SER 587 
326 1 Y 1 B SER 588 ? B SER 588 
327 1 Y 1 B ASP 589 ? B ASP 589 
328 1 Y 1 B THR 590 ? B THR 590 
329 1 Y 1 B PRO 591 ? B PRO 591 
330 1 Y 1 B GLU 592 ? B GLU 592 
331 1 Y 1 B MET 593 ? B MET 593 
332 1 Y 1 B SER 594 ? B SER 594 
333 1 Y 1 B LEU 595 ? B LEU 595 
334 1 Y 1 B SER 596 ? B SER 596 
335 1 Y 1 B ALA 597 ? B ALA 597 
336 1 Y 1 B GLU 598 ? B GLU 598 
337 1 Y 1 B THR 599 ? B THR 599 
338 1 Y 1 B LEU 600 ? B LEU 600 
339 1 Y 1 B SER 601 ? B SER 601 
340 1 Y 1 B PRO 602 ? B PRO 602 
341 1 Y 1 B SER 603 ? B SER 603 
342 1 Y 1 B THR 604 ? B THR 604 
343 1 Y 1 B PRO 605 ? B PRO 605 
344 1 Y 1 B SER 606 ? B SER 606 
345 1 Y 1 B ASP 607 ? B ASP 607 
346 1 Y 1 B VAL 608 ? B VAL 608 
347 1 Y 1 B ASN 609 ? B ASN 609 
348 1 Y 1 B PHE 610 ? B PHE 610 
349 1 Y 1 B LEU 611 ? B LEU 611 
350 1 Y 1 B LEU 612 ? B LEU 612 
351 1 Y 1 B PRO 613 ? B PRO 613 
352 1 Y 1 B PRO 614 ? B PRO 614 
353 1 Y 1 B GLU 615 ? B GLU 615 
354 1 Y 1 B ASP 616 ? B ASP 616 
355 1 Y 1 B ALA 617 ? B ALA 617 
356 1 Y 1 B GLY 618 ? B GLY 618 
357 1 Y 1 B GLU 619 ? B GLU 619 
358 1 Y 1 B GLU 620 ? B GLU 620 
359 1 Y 1 B ALA 621 ? B ALA 621 
360 1 Y 1 B GLU 622 ? B GLU 622 
361 1 Y 1 B ALA 623 ? B ALA 623 
362 1 Y 1 B LYS 624 ? B LYS 624 
363 1 Y 1 B ASN 625 ? B ASN 625 
364 1 Y 1 B GLU 626 ? B GLU 626 
365 1 Y 1 B LEU 627 ? B LEU 627 
366 1 Y 1 B SER 628 ? B SER 628 
367 1 Y 1 B PRO 629 ? B PRO 629 
368 1 Y 1 B MET 630 ? B MET 630 
369 1 Y 1 B ASP 631 ? B ASP 631 
370 1 Y 1 B ARG 632 ? B ARG 632 
371 1 Y 1 B GLY 633 ? B GLY 633 
372 1 Y 1 B LEU 634 ? B LEU 634 
373 1 Y 1 B GLY 635 ? B GLY 635 
374 1 Y 1 B VAL 636 ? B VAL 636 
375 1 Y 1 B ARG 637 ? B ARG 637 
376 1 Y 1 B PRO 753 ? B PRO 753 
377 1 Y 1 B ALA 754 ? B ALA 754 
378 1 Y 1 B GLY 755 ? B GLY 755 
379 1 Y 1 B ALA 756 ? B ALA 756 
380 1 Y 1 B GLY 757 ? B GLY 757 
381 1 Y 1 B PRO 758 ? B PRO 758 
382 1 Y 1 B SER 759 ? B SER 759 
383 1 Y 1 B GLY 760 ? B GLY 760 
384 1 Y 1 B GLU 761 ? B GLU 761 
385 1 Y 1 B THR 762 ? B THR 762 
386 1 Y 1 B GLY 763 ? B GLY 763 
387 1 Y 1 B ALA 764 ? B ALA 764 
388 1 Y 1 B ALA 765 ? B ALA 765 
389 1 Y 1 B GLY 766 ? B GLY 766 
390 1 Y 1 B VAL 767 ? B VAL 767 
391 1 Y 1 B ASP 768 ? B ASP 768 
392 1 Y 1 B GLY 769 ? B GLY 769 
393 1 Y 1 B GLY 770 ? B GLY 770 
394 1 Y 1 B CYS 771 ? B CYS 771 
395 1 Y 1 B GLY 772 ? B GLY 772 
396 1 Y 1 B GLY 773 ? B GLY 773 
397 1 Y 1 B ARG 774 ? B ARG 774 
398 1 Y 1 B HIS 775 ? B HIS 775 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-06-11 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8ZVQ 
_em_admin.last_update        2025-04-23 
_em_admin.map_release_date   2025-04-23 
_em_admin.title              'Cryo-EM Structure of Human Hormone-sensitive Lipase (HSL)' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? 
MASKING                         ? 3  ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8ZVQ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . ARG A 1 4   ? 88.328  146.040 106.013 1.00 84.80  ? 4   ARG A N   1 
ATOM 2    C CA  . ARG A 1 4   ? 86.934  146.389 106.263 1.00 85.23  ? 4   ARG A CA  1 
ATOM 3    C C   . ARG A 1 4   ? 86.026  145.179 106.071 1.00 84.37  ? 4   ARG A C   1 
ATOM 4    O O   . ARG A 1 4   ? 85.081  144.975 106.832 1.00 84.24  ? 4   ARG A O   1 
ATOM 5    C CB  . ARG A 1 4   ? 86.498  147.535 105.349 1.00 84.41  ? 4   ARG A CB  1 
ATOM 6    C CG  . ARG A 1 4   ? 87.442  148.731 105.358 1.00 83.86  ? 4   ARG A CG  1 
ATOM 7    C CD  . ARG A 1 4   ? 87.401  149.470 106.692 1.00 84.01  ? 4   ARG A CD  1 
ATOM 8    N NE  . ARG A 1 4   ? 88.493  149.085 107.579 1.00 83.64  ? 4   ARG A NE  1 
ATOM 9    C CZ  . ARG A 1 4   ? 89.553  149.838 107.837 1.00 84.92  ? 4   ARG A CZ  1 
ATOM 10   N NH1 . ARG A 1 4   ? 89.704  151.031 107.286 1.00 82.04  ? 4   ARG A NH1 1 
ATOM 11   N NH2 . ARG A 1 4   ? 90.486  149.383 108.668 1.00 83.28  ? 4   ARG A NH2 1 
ATOM 12   N N   . THR A 1 5   ? 86.317  144.376 105.045 1.00 88.49  ? 5   THR A N   1 
ATOM 13   C CA  . THR A 1 5   ? 85.575  143.138 104.841 1.00 89.63  ? 5   THR A CA  1 
ATOM 14   C C   . THR A 1 5   ? 85.948  142.071 105.861 1.00 92.66  ? 5   THR A C   1 
ATOM 15   O O   . THR A 1 5   ? 85.147  141.164 106.111 1.00 90.30  ? 5   THR A O   1 
ATOM 16   C CB  . THR A 1 5   ? 85.802  142.605 103.424 1.00 90.57  ? 5   THR A CB  1 
ATOM 17   O OG1 . THR A 1 5   ? 85.208  141.307 103.298 1.00 86.69  ? 5   THR A OG1 1 
ATOM 18   C CG2 . THR A 1 5   ? 87.289  142.513 103.109 1.00 90.55  ? 5   THR A CG2 1 
ATOM 19   N N   . MET A 1 6   ? 87.142  142.157 106.449 1.00 90.65  ? 6   MET A N   1 
ATOM 20   C CA  . MET A 1 6   ? 87.547  141.201 107.473 1.00 87.95  ? 6   MET A CA  1 
ATOM 21   C C   . MET A 1 6   ? 86.885  141.502 108.811 1.00 81.77  ? 6   MET A C   1 
ATOM 22   O O   . MET A 1 6   ? 86.570  140.580 109.572 1.00 79.95  ? 6   MET A O   1 
ATOM 23   C CB  . MET A 1 6   ? 89.068  141.207 107.618 1.00 85.85  ? 6   MET A CB  1 
ATOM 24   C CG  . MET A 1 6   ? 89.816  141.361 106.303 1.00 86.03  ? 6   MET A CG  1 
ATOM 25   S SD  . MET A 1 6   ? 90.073  139.790 105.459 1.00 85.93  ? 6   MET A SD  1 
ATOM 26   C CE  . MET A 1 6   ? 91.329  139.056 106.503 1.00 85.68  ? 6   MET A CE  1 
ATOM 27   N N   . THR A 1 7   ? 86.677  142.784 109.118 1.00 83.33  ? 7   THR A N   1 
ATOM 28   C CA  . THR A 1 7   ? 86.069  143.162 110.389 1.00 92.86  ? 7   THR A CA  1 
ATOM 29   C C   . THR A 1 7   ? 84.569  142.887 110.407 1.00 92.90  ? 7   THR A C   1 
ATOM 30   O O   . THR A 1 7   ? 84.041  142.397 111.411 1.00 89.62  ? 7   THR A O   1 
ATOM 31   C CB  . THR A 1 7   ? 86.343  144.639 110.684 1.00 91.29  ? 7   THR A CB  1 
ATOM 32   O OG1 . THR A 1 7   ? 85.339  145.447 110.059 1.00 90.68  ? 7   THR A OG1 1 
ATOM 33   C CG2 . THR A 1 7   ? 87.715  145.048 110.163 1.00 86.44  ? 7   THR A CG2 1 
ATOM 34   N N   . GLN A 1 8   ? 83.870  143.194 109.309 1.00 85.63  ? 8   GLN A N   1 
ATOM 35   C CA  . GLN A 1 8   ? 82.423  143.001 109.238 1.00 82.56  ? 8   GLN A CA  1 
ATOM 36   C C   . GLN A 1 8   ? 82.044  141.526 109.232 1.00 86.16  ? 8   GLN A C   1 
ATOM 37   O O   . GLN A 1 8   ? 80.980  141.170 109.748 1.00 86.59  ? 8   GLN A O   1 
ATOM 38   C CB  . GLN A 1 8   ? 81.870  143.685 107.978 1.00 85.47  ? 8   GLN A CB  1 
ATOM 39   C CG  . GLN A 1 8   ? 80.366  143.513 107.541 1.00 82.90  ? 8   GLN A CG  1 
ATOM 40   C CD  . GLN A 1 8   ? 79.250  143.837 108.564 1.00 83.70  ? 8   GLN A CD  1 
ATOM 41   O OE1 . GLN A 1 8   ? 78.628  144.895 108.567 1.00 82.37  ? 8   GLN A OE1 1 
ATOM 42   N NE2 . GLN A 1 8   ? 79.019  142.885 109.462 1.00 83.50  ? 8   GLN A NE2 1 
ATOM 43   N N   . SER A 1 9   ? 82.899  140.663 108.672 1.00 82.24  ? 9   SER A N   1 
ATOM 44   C CA  . SER A 1 9   ? 82.574  139.244 108.554 1.00 78.55  ? 9   SER A CA  1 
ATOM 45   C C   . SER A 1 9   ? 82.440  138.585 109.921 1.00 79.50  ? 9   SER A C   1 
ATOM 46   O O   . SER A 1 9   ? 81.617  137.681 110.100 1.00 79.53  ? 9   SER A O   1 
ATOM 47   C CB  . SER A 1 9   ? 83.631  138.532 107.712 1.00 79.77  ? 9   SER A CB  1 
ATOM 48   O OG  . SER A 1 9   ? 84.928  138.788 108.213 1.00 79.20  ? 9   SER A OG  1 
ATOM 49   N N   . LEU A 1 10  ? 83.230  139.025 110.899 1.00 73.37  ? 10  LEU A N   1 
ATOM 50   C CA  . LEU A 1 10  ? 83.025  138.551 112.262 1.00 72.16  ? 10  LEU A CA  1 
ATOM 51   C C   . LEU A 1 10  ? 81.754  139.131 112.868 1.00 74.63  ? 10  LEU A C   1 
ATOM 52   O O   . LEU A 1 10  ? 81.091  138.464 113.672 1.00 74.09  ? 10  LEU A O   1 
ATOM 53   C CB  . LEU A 1 10  ? 84.234  138.901 113.128 1.00 74.04  ? 10  LEU A CB  1 
ATOM 54   C CG  . LEU A 1 10  ? 85.237  137.776 113.381 1.00 75.85  ? 10  LEU A CG  1 
ATOM 55   C CD1 . LEU A 1 10  ? 86.381  138.270 114.249 1.00 70.70  ? 10  LEU A CD1 1 
ATOM 56   C CD2 . LEU A 1 10  ? 84.556  136.572 114.011 1.00 76.75  ? 10  LEU A CD2 1 
ATOM 57   N N   . VAL A 1 11  ? 81.401  140.365 112.501 1.00 76.96  ? 11  VAL A N   1 
ATOM 58   C CA  . VAL A 1 11  ? 80.229  141.016 113.081 1.00 74.38  ? 11  VAL A CA  1 
ATOM 59   C C   . VAL A 1 11  ? 78.941  140.435 112.504 1.00 75.96  ? 11  VAL A C   1 
ATOM 60   O O   . VAL A 1 11  ? 77.965  140.217 113.231 1.00 76.46  ? 11  VAL A O   1 
ATOM 61   C CB  . VAL A 1 11  ? 80.317  142.541 112.877 1.00 77.12  ? 11  VAL A CB  1 
ATOM 62   C CG1 . VAL A 1 11  ? 79.089  143.242 113.446 1.00 75.91  ? 11  VAL A CG1 1 
ATOM 63   C CG2 . VAL A 1 11  ? 81.582  143.087 113.518 1.00 75.39  ? 11  VAL A CG2 1 
ATOM 64   N N   . THR A 1 12  ? 78.911  140.169 111.197 1.00 82.71  ? 12  THR A N   1 
ATOM 65   C CA  . THR A 1 12  ? 77.690  139.662 110.579 1.00 82.49  ? 12  THR A CA  1 
ATOM 66   C C   . THR A 1 12  ? 77.399  138.206 110.929 1.00 81.09  ? 12  THR A C   1 
ATOM 67   O O   . THR A 1 12  ? 76.290  137.734 110.656 1.00 82.73  ? 12  THR A O   1 
ATOM 68   C CB  . THR A 1 12  ? 77.749  139.825 109.055 1.00 82.64  ? 12  THR A CB  1 
ATOM 69   O OG1 . THR A 1 12  ? 76.501  139.416 108.480 1.00 81.70  ? 12  THR A OG1 1 
ATOM 70   C CG2 . THR A 1 12  ? 78.861  138.989 108.462 1.00 81.09  ? 12  THR A CG2 1 
ATOM 71   N N   . LEU A 1 13  ? 78.352  137.489 111.526 1.00 81.57  ? 13  LEU A N   1 
ATOM 72   C CA  . LEU A 1 13  ? 78.134  136.137 112.030 1.00 82.04  ? 13  LEU A CA  1 
ATOM 73   C C   . LEU A 1 13  ? 77.983  136.098 113.546 1.00 81.56  ? 13  LEU A C   1 
ATOM 74   O O   . LEU A 1 13  ? 78.160  135.038 114.154 1.00 81.37  ? 13  LEU A O   1 
ATOM 75   C CB  . LEU A 1 13  ? 79.271  135.205 111.603 1.00 78.69  ? 13  LEU A CB  1 
ATOM 76   C CG  . LEU A 1 13  ? 79.266  134.490 110.247 1.00 80.64  ? 13  LEU A CG  1 
ATOM 77   C CD1 . LEU A 1 13  ? 79.470  135.428 109.076 1.00 80.72  ? 13  LEU A CD1 1 
ATOM 78   C CD2 . LEU A 1 13  ? 80.329  133.397 110.239 1.00 80.47  ? 13  LEU A CD2 1 
ATOM 79   N N   . ALA A 1 14  ? 77.647  137.226 114.173 1.00 87.45  ? 14  ALA A N   1 
ATOM 80   C CA  . ALA A 1 14  ? 77.639  137.317 115.631 1.00 84.14  ? 14  ALA A CA  1 
ATOM 81   C C   . ALA A 1 14  ? 76.273  137.017 116.237 1.00 88.91  ? 14  ALA A C   1 
ATOM 82   O O   . ALA A 1 14  ? 76.150  136.105 117.062 1.00 89.27  ? 14  ALA A O   1 
ATOM 83   C CB  . ALA A 1 14  ? 78.119  138.702 116.079 1.00 85.14  ? 14  ALA A CB  1 
ATOM 84   N N   . GLU A 1 15  ? 75.246  137.782 115.851 1.00 92.58  ? 15  GLU A N   1 
ATOM 85   C CA  . GLU A 1 15  ? 73.932  137.651 116.476 1.00 93.92  ? 15  GLU A CA  1 
ATOM 86   C C   . GLU A 1 15  ? 73.300  136.294 116.202 1.00 98.04  ? 15  GLU A C   1 
ATOM 87   O O   . GLU A 1 15  ? 72.653  135.725 117.091 1.00 94.58  ? 15  GLU A O   1 
ATOM 88   C CB  . GLU A 1 15  ? 73.004  138.772 116.003 1.00 91.91  ? 15  GLU A CB  1 
ATOM 89   C CG  . GLU A 1 15  ? 71.622  138.759 116.652 1.00 92.75  ? 15  GLU A CG  1 
ATOM 90   C CD  . GLU A 1 15  ? 71.657  139.093 118.132 1.00 92.74  ? 15  GLU A CD  1 
ATOM 91   O OE1 . GLU A 1 15  ? 72.561  139.843 118.555 1.00 92.73  ? 15  GLU A OE1 1 
ATOM 92   O OE2 . GLU A 1 15  ? 70.780  138.601 118.875 1.00 92.74  ? 15  GLU A OE2 1 
ATOM 93   N N   . ASP A 1 16  ? 73.467  135.762 114.986 1.00 102.31 ? 16  ASP A N   1 
ATOM 94   C CA  . ASP A 1 16  ? 72.946  134.431 114.698 1.00 95.55  ? 16  ASP A CA  1 
ATOM 95   C C   . ASP A 1 16  ? 73.643  133.379 115.557 1.00 95.80  ? 16  ASP A C   1 
ATOM 96   O O   . ASP A 1 16  ? 72.981  132.561 116.202 1.00 94.20  ? 16  ASP A O   1 
ATOM 97   C CB  . ASP A 1 16  ? 73.039  134.134 113.188 1.00 97.76  ? 16  ASP A CB  1 
ATOM 98   C CG  . ASP A 1 16  ? 74.463  133.890 112.689 1.00 97.56  ? 16  ASP A CG  1 
ATOM 99   O OD1 . ASP A 1 16  ? 75.001  134.776 111.992 1.00 92.14  ? 16  ASP A OD1 1 
ATOM 100  O OD2 . ASP A 1 16  ? 75.025  132.800 112.936 1.00 98.28  ? 16  ASP A OD2 1 
ATOM 101  N N   . ASN A 1 17  ? 74.972  133.461 115.674 1.00 95.25  ? 17  ASN A N   1 
ATOM 102  C CA  . ASN A 1 17  ? 75.692  132.519 116.522 1.00 96.02  ? 17  ASN A CA  1 
ATOM 103  C C   . ASN A 1 17  ? 75.433  132.779 117.998 1.00 95.00  ? 17  ASN A C   1 
ATOM 104  O O   . ASN A 1 17  ? 75.557  131.858 118.813 1.00 98.21  ? 17  ASN A O   1 
ATOM 105  C CB  . ASN A 1 17  ? 77.190  132.572 116.226 1.00 92.00  ? 17  ASN A CB  1 
ATOM 106  C CG  . ASN A 1 17  ? 77.570  131.740 115.017 1.00 91.06  ? 17  ASN A CG  1 
ATOM 107  O OD1 . ASN A 1 17  ? 76.754  130.982 114.492 1.00 93.09  ? 17  ASN A OD1 1 
ATOM 108  N ND2 . ASN A 1 17  ? 78.814  131.869 114.573 1.00 92.23  ? 17  ASN A ND2 1 
ATOM 109  N N   . ILE A 1 18  ? 75.074  134.011 118.360 1.00 91.42  ? 18  ILE A N   1 
ATOM 110  C CA  . ILE A 1 18  ? 74.548  134.260 119.697 1.00 91.31  ? 18  ILE A CA  1 
ATOM 111  C C   . ILE A 1 18  ? 73.192  133.578 119.860 1.00 91.68  ? 18  ILE A C   1 
ATOM 112  O O   . ILE A 1 18  ? 72.927  132.915 120.871 1.00 91.68  ? 18  ILE A O   1 
ATOM 113  C CB  . ILE A 1 18  ? 74.473  135.775 119.970 1.00 91.10  ? 18  ILE A CB  1 
ATOM 114  C CG1 . ILE A 1 18  ? 75.862  136.317 120.319 1.00 90.24  ? 18  ILE A CG1 1 
ATOM 115  C CG2 . ILE A 1 18  ? 73.499  136.091 121.098 1.00 91.09  ? 18  ILE A CG2 1 
ATOM 116  C CD1 . ILE A 1 18  ? 75.977  137.821 120.224 1.00 90.26  ? 18  ILE A CD1 1 
ATOM 117  N N   . ALA A 1 19  ? 72.327  133.700 118.850 1.00 96.79  ? 19  ALA A N   1 
ATOM 118  C CA  . ALA A 1 19  ? 71.016  133.063 118.904 1.00 97.69  ? 19  ALA A CA  1 
ATOM 119  C C   . ALA A 1 19  ? 71.085  131.555 118.689 1.00 99.11  ? 19  ALA A C   1 
ATOM 120  O O   . ALA A 1 19  ? 70.147  130.847 119.071 1.00 98.18  ? 19  ALA A O   1 
ATOM 121  C CB  . ALA A 1 19  ? 70.084  133.692 117.868 1.00 97.18  ? 19  ALA A CB  1 
ATOM 122  N N   . PHE A 1 20  ? 72.164  131.053 118.079 1.00 104.22 ? 20  PHE A N   1 
ATOM 123  C CA  . PHE A 1 20  ? 72.307  129.614 117.871 1.00 102.31 ? 20  PHE A CA  1 
ATOM 124  C C   . PHE A 1 20  ? 72.497  128.870 119.188 1.00 102.34 ? 20  PHE A C   1 
ATOM 125  O O   . PHE A 1 20  ? 72.008  127.746 119.344 1.00 103.19 ? 20  PHE A O   1 
ATOM 126  C CB  . PHE A 1 20  ? 73.476  129.332 116.924 1.00 102.64 ? 20  PHE A CB  1 
ATOM 127  C CG  . PHE A 1 20  ? 73.068  129.099 115.491 1.00 106.32 ? 20  PHE A CG  1 
ATOM 128  C CD1 . PHE A 1 20  ? 72.205  129.966 114.841 1.00 102.50 ? 20  PHE A CD1 1 
ATOM 129  C CD2 . PHE A 1 20  ? 73.585  128.028 114.783 1.00 102.74 ? 20  PHE A CD2 1 
ATOM 130  C CE1 . PHE A 1 20  ? 71.843  129.758 113.525 1.00 105.08 ? 20  PHE A CE1 1 
ATOM 131  C CE2 . PHE A 1 20  ? 73.230  127.812 113.465 1.00 105.84 ? 20  PHE A CE2 1 
ATOM 132  C CZ  . PHE A 1 20  ? 72.357  128.679 112.834 1.00 109.04 ? 20  PHE A CZ  1 
ATOM 133  N N   . PHE A 1 21  ? 73.202  129.472 120.143 1.00 101.36 ? 21  PHE A N   1 
ATOM 134  C CA  . PHE A 1 21  ? 73.512  128.792 121.395 1.00 103.27 ? 21  PHE A CA  1 
ATOM 135  C C   . PHE A 1 21  ? 72.628  129.220 122.557 1.00 103.15 ? 21  PHE A C   1 
ATOM 136  O O   . PHE A 1 21  ? 72.405  128.422 123.474 1.00 105.35 ? 21  PHE A O   1 
ATOM 137  C CB  . PHE A 1 21  ? 74.981  129.019 121.769 1.00 98.60  ? 21  PHE A CB  1 
ATOM 138  C CG  . PHE A 1 21  ? 75.653  127.807 122.347 1.00 96.20  ? 21  PHE A CG  1 
ATOM 139  C CD1 . PHE A 1 21  ? 75.496  127.483 123.683 1.00 98.63  ? 21  PHE A CD1 1 
ATOM 140  C CD2 . PHE A 1 21  ? 76.433  126.986 121.550 1.00 95.31  ? 21  PHE A CD2 1 
ATOM 141  C CE1 . PHE A 1 21  ? 76.112  126.368 124.220 1.00 100.33 ? 21  PHE A CE1 1 
ATOM 142  C CE2 . PHE A 1 21  ? 77.052  125.868 122.080 1.00 97.45  ? 21  PHE A CE2 1 
ATOM 143  C CZ  . PHE A 1 21  ? 76.889  125.559 123.417 1.00 98.29  ? 21  PHE A CZ  1 
ATOM 144  N N   . SER A 1 22  ? 72.120  130.453 122.548 1.00 94.92  ? 22  SER A N   1 
ATOM 145  C CA  . SER A 1 22  ? 71.284  130.927 123.645 1.00 95.41  ? 22  SER A CA  1 
ATOM 146  C C   . SER A 1 22  ? 69.871  130.360 123.606 1.00 95.67  ? 22  SER A C   1 
ATOM 147  O O   . SER A 1 22  ? 69.186  130.374 124.635 1.00 95.53  ? 22  SER A O   1 
ATOM 148  C CB  . SER A 1 22  ? 71.222  132.455 123.634 1.00 95.46  ? 22  SER A CB  1 
ATOM 149  O OG  . SER A 1 22  ? 70.899  132.940 122.343 1.00 95.68  ? 22  SER A OG  1 
ATOM 150  N N   . SER A 1 23  ? 69.419  129.865 122.455 1.00 100.79 ? 23  SER A N   1 
ATOM 151  C CA  . SER A 1 23  ? 68.063  129.350 122.321 1.00 101.02 ? 23  SER A CA  1 
ATOM 152  C C   . SER A 1 23  ? 67.958  127.850 122.564 1.00 101.03 ? 23  SER A C   1 
ATOM 153  O O   . SER A 1 23  ? 66.840  127.325 122.601 1.00 99.19  ? 23  SER A O   1 
ATOM 154  C CB  . SER A 1 23  ? 67.514  129.674 120.928 1.00 103.94 ? 23  SER A CB  1 
ATOM 155  O OG  . SER A 1 23  ? 68.398  129.223 119.918 1.00 104.05 ? 23  SER A OG  1 
ATOM 156  N N   . GLN A 1 24  ? 69.078  127.150 122.733 1.00 105.04 ? 24  GLN A N   1 
ATOM 157  C CA  . GLN A 1 24  ? 69.091  125.698 122.901 1.00 105.31 ? 24  GLN A CA  1 
ATOM 158  C C   . GLN A 1 24  ? 69.809  125.316 124.187 1.00 107.71 ? 24  GLN A C   1 
ATOM 159  O O   . GLN A 1 24  ? 70.689  124.452 124.208 1.00 109.08 ? 24  GLN A O   1 
ATOM 160  C CB  . GLN A 1 24  ? 69.736  124.991 121.710 1.00 105.50 ? 24  GLN A CB  1 
ATOM 161  C CG  . GLN A 1 24  ? 69.657  125.740 120.393 1.00 105.82 ? 24  GLN A CG  1 
ATOM 162  C CD  . GLN A 1 24  ? 70.375  125.015 119.273 1.00 107.60 ? 24  GLN A CD  1 
ATOM 163  O OE1 . GLN A 1 24  ? 71.599  124.886 119.285 1.00 108.91 ? 24  GLN A OE1 1 
ATOM 164  N NE2 . GLN A 1 24  ? 69.614  124.535 118.296 1.00 105.68 ? 24  GLN A NE2 1 
ATOM 165  N N   . GLY A 1 25  ? 69.439  125.963 125.287 1.00 96.54  ? 25  GLY A N   1 
ATOM 166  C CA  . GLY A 1 25  ? 69.971  125.613 126.580 1.00 94.83  ? 25  GLY A CA  1 
ATOM 167  C C   . GLY A 1 25  ? 70.003  126.777 127.549 1.00 93.78  ? 25  GLY A C   1 
ATOM 168  O O   . GLY A 1 25  ? 70.422  127.889 127.214 1.00 93.18  ? 25  GLY A O   1 
ATOM 169  N N   . PRO A 1 26  ? 69.552  126.535 128.780 1.00 86.04  ? 26  PRO A N   1 
ATOM 170  C CA  . PRO A 1 26  ? 69.593  127.570 129.827 1.00 85.40  ? 26  PRO A CA  1 
ATOM 171  C C   . PRO A 1 26  ? 70.820  127.517 130.730 1.00 86.32  ? 26  PRO A C   1 
ATOM 172  O O   . PRO A 1 26  ? 70.839  128.232 131.737 1.00 87.62  ? 26  PRO A O   1 
ATOM 173  C CB  . PRO A 1 26  ? 68.328  127.251 130.632 1.00 85.68  ? 26  PRO A CB  1 
ATOM 174  C CG  . PRO A 1 26  ? 68.193  125.756 130.527 1.00 85.74  ? 26  PRO A CG  1 
ATOM 175  C CD  . PRO A 1 26  ? 68.870  125.314 129.245 1.00 87.41  ? 26  PRO A CD  1 
ATOM 176  N N   . GLY A 1 27  ? 71.820  126.705 130.402 1.00 83.45  ? 27  GLY A N   1 
ATOM 177  C CA  . GLY A 1 27  ? 72.989  126.564 131.241 1.00 82.79  ? 27  GLY A CA  1 
ATOM 178  C C   . GLY A 1 27  ? 73.921  127.758 131.143 1.00 82.49  ? 27  GLY A C   1 
ATOM 179  O O   . GLY A 1 27  ? 73.663  128.752 130.463 1.00 81.33  ? 27  GLY A O   1 
ATOM 180  N N   . GLU A 1 28  ? 75.040  127.647 131.863 1.00 84.68  ? 28  GLU A N   1 
ATOM 181  C CA  . GLU A 1 28  ? 76.015  128.732 131.894 1.00 84.77  ? 28  GLU A CA  1 
ATOM 182  C C   . GLU A 1 28  ? 76.727  128.893 130.557 1.00 87.21  ? 28  GLU A C   1 
ATOM 183  O O   . GLU A 1 28  ? 77.091  130.014 130.186 1.00 86.04  ? 28  GLU A O   1 
ATOM 184  C CB  . GLU A 1 28  ? 77.038  128.492 133.005 1.00 88.18  ? 28  GLU A CB  1 
ATOM 185  C CG  . GLU A 1 28  ? 77.628  127.090 133.016 1.00 85.54  ? 28  GLU A CG  1 
ATOM 186  C CD  . GLU A 1 28  ? 78.447  126.809 134.257 1.00 85.73  ? 28  GLU A CD  1 
ATOM 187  O OE1 . GLU A 1 28  ? 78.468  127.665 135.165 1.00 84.80  ? 28  GLU A OE1 1 
ATOM 188  O OE2 . GLU A 1 28  ? 79.077  125.733 134.322 1.00 87.36  ? 28  GLU A OE2 1 
ATOM 189  N N   . THR A 1 29  ? 76.915  127.792 129.821 1.00 85.31  ? 29  THR A N   1 
ATOM 190  C CA  . THR A 1 29  ? 77.726  127.823 128.607 1.00 83.78  ? 29  THR A CA  1 
ATOM 191  C C   . THR A 1 29  ? 77.080  128.650 127.503 1.00 84.56  ? 29  THR A C   1 
ATOM 192  O O   . THR A 1 29  ? 77.792  129.224 126.673 0.62 84.02  ? 29  THR A O   1 
ATOM 193  C CB  . THR A 1 29  ? 77.990  126.401 128.114 1.00 81.51  ? 29  THR A CB  1 
ATOM 194  O OG1 . THR A 1 29  ? 76.757  125.799 127.701 1.00 83.87  ? 29  THR A OG1 1 
ATOM 195  C CG2 . THR A 1 29  ? 78.614  125.564 129.222 1.00 81.09  ? 29  THR A CG2 1 
ATOM 196  N N   . ALA A 1 30  ? 75.747  128.731 127.480 1.00 86.92  ? 30  ALA A N   1 
ATOM 197  C CA  . ALA A 1 30  ? 75.074  129.594 126.512 1.00 87.31  ? 30  ALA A CA  1 
ATOM 198  C C   . ALA A 1 30  ? 75.409  131.058 126.762 1.00 90.65  ? 30  ALA A C   1 
ATOM 199  O O   . ALA A 1 30  ? 75.737  131.802 125.828 1.00 92.27  ? 30  ALA A O   1 
ATOM 200  C CB  . ALA A 1 30  ? 73.564  129.369 126.567 1.00 87.85  ? 30  ALA A CB  1 
ATOM 201  N N   . GLN A 1 31  ? 75.353  131.480 128.029 1.00 91.47  ? 31  GLN A N   1 
ATOM 202  C CA  . GLN A 1 31  ? 75.733  132.842 128.388 1.00 91.76  ? 31  GLN A CA  1 
ATOM 203  C C   . GLN A 1 31  ? 77.206  133.095 128.099 1.00 85.95  ? 31  GLN A C   1 
ATOM 204  O O   . GLN A 1 31  ? 77.571  134.167 127.599 1.00 86.82  ? 31  GLN A O   1 
ATOM 205  C CB  . GLN A 1 31  ? 75.430  133.098 129.865 1.00 90.64  ? 31  GLN A CB  1 
ATOM 206  C CG  . GLN A 1 31  ? 73.952  133.070 130.218 1.00 90.48  ? 31  GLN A CG  1 
ATOM 207  C CD  . GLN A 1 31  ? 73.595  131.906 131.123 1.00 88.60  ? 31  GLN A CD  1 
ATOM 208  O OE1 . GLN A 1 31  ? 74.127  131.776 132.226 1.00 87.40  ? 31  GLN A OE1 1 
ATOM 209  N NE2 . GLN A 1 31  ? 72.691  131.051 130.660 1.00 87.33  ? 31  GLN A NE2 1 
ATOM 210  N N   . ARG A 1 32  ? 78.061  132.108 128.397 1.00 83.45  ? 32  ARG A N   1 
ATOM 211  C CA  . ARG A 1 32  ? 79.493  132.238 128.136 1.00 83.21  ? 32  ARG A CA  1 
ATOM 212  C C   . ARG A 1 32  ? 79.771  132.439 126.652 1.00 82.66  ? 32  ARG A C   1 
ATOM 213  O O   . ARG A 1 32  ? 80.497  133.361 126.269 1.00 86.70  ? 32  ARG A O   1 
ATOM 214  C CB  . ARG A 1 32  ? 80.240  131.004 128.645 1.00 83.38  ? 32  ARG A CB  1 
ATOM 215  C CG  . ARG A 1 32  ? 80.203  130.781 130.148 1.00 83.15  ? 32  ARG A CG  1 
ATOM 216  C CD  . ARG A 1 32  ? 81.501  131.182 130.820 1.00 80.69  ? 32  ARG A CD  1 
ATOM 217  N NE  . ARG A 1 32  ? 81.684  130.469 132.079 1.00 80.77  ? 32  ARG A NE  1 
ATOM 218  C CZ  . ARG A 1 32  ? 82.664  130.704 132.940 1.00 83.14  ? 32  ARG A CZ  1 
ATOM 219  N NH1 . ARG A 1 32  ? 83.575  131.635 132.714 1.00 88.16  ? 32  ARG A NH1 1 
ATOM 220  N NH2 . ARG A 1 32  ? 82.731  129.986 134.058 1.00 83.14  ? 32  ARG A NH2 1 
ATOM 221  N N   . LEU A 1 33  ? 79.177  131.603 125.798 1.00 75.94  ? 33  LEU A N   1 
ATOM 222  C CA  . LEU A 1 33  ? 79.457  131.697 124.369 1.00 79.18  ? 33  LEU A CA  1 
ATOM 223  C C   . LEU A 1 33  ? 78.838  132.948 123.756 1.00 79.90  ? 33  LEU A C   1 
ATOM 224  O O   . LEU A 1 33  ? 79.449  133.575 122.881 1.00 79.00  ? 33  LEU A O   1 
ATOM 225  C CB  . LEU A 1 33  ? 78.969  130.441 123.649 1.00 82.35  ? 33  LEU A CB  1 
ATOM 226  C CG  . LEU A 1 33  ? 79.865  129.917 122.519 1.00 82.66  ? 33  LEU A CG  1 
ATOM 227  C CD1 . LEU A 1 33  ? 81.340  130.201 122.783 1.00 81.78  ? 33  LEU A CD1 1 
ATOM 228  C CD2 . LEU A 1 33  ? 79.647  128.431 122.305 1.00 76.88  ? 33  LEU A CD2 1 
ATOM 229  N N   . SER A 1 34  ? 77.639  133.337 124.207 1.00 74.42  ? 34  SER A N   1 
ATOM 230  C CA  . SER A 1 34  ? 77.024  134.560 123.697 1.00 82.34  ? 34  SER A CA  1 
ATOM 231  C C   . SER A 1 34  ? 77.839  135.791 124.077 1.00 85.90  ? 34  SER A C   1 
ATOM 232  O O   . SER A 1 34  ? 78.085  136.664 123.234 1.00 87.78  ? 34  SER A O   1 
ATOM 233  C CB  . SER A 1 34  ? 75.592  134.683 124.213 1.00 84.03  ? 34  SER A CB  1 
ATOM 234  O OG  . SER A 1 34  ? 74.952  133.420 124.239 1.00 90.94  ? 34  SER A OG  1 
ATOM 235  N N   . GLY A 1 35  ? 78.289  135.866 125.334 1.00 77.61  ? 35  GLY A N   1 
ATOM 236  C CA  . GLY A 1 35  ? 79.130  136.977 125.743 1.00 73.94  ? 35  GLY A CA  1 
ATOM 237  C C   . GLY A 1 35  ? 80.479  136.975 125.052 1.00 69.75  ? 35  GLY A C   1 
ATOM 238  O O   . GLY A 1 35  ? 81.013  138.035 124.720 1.00 71.59  ? 35  GLY A O   1 
ATOM 239  N N   . VAL A 1 36  ? 81.035  135.785 124.804 1.00 61.98  ? 36  VAL A N   1 
ATOM 240  C CA  . VAL A 1 36  ? 82.316  135.678 124.113 1.00 63.62  ? 36  VAL A CA  1 
ATOM 241  C C   . VAL A 1 36  ? 82.196  136.191 122.684 1.00 65.35  ? 36  VAL A C   1 
ATOM 242  O O   . VAL A 1 36  ? 83.043  136.955 122.208 1.00 64.25  ? 36  VAL A O   1 
ATOM 243  C CB  . VAL A 1 36  ? 82.828  134.225 124.165 1.00 62.53  ? 36  VAL A CB  1 
ATOM 244  C CG1 . VAL A 1 36  ? 83.699  133.900 122.970 1.00 61.44  ? 36  VAL A CG1 1 
ATOM 245  C CG2 . VAL A 1 36  ? 83.610  133.998 125.444 1.00 64.23  ? 36  VAL A CG2 1 
ATOM 246  N N   . PHE A 1 37  ? 81.123  135.815 121.988 1.00 62.90  ? 37  PHE A N   1 
ATOM 247  C CA  . PHE A 1 37  ? 81.017  136.224 120.592 1.00 62.49  ? 37  PHE A CA  1 
ATOM 248  C C   . PHE A 1 37  ? 80.615  137.693 120.477 1.00 66.64  ? 37  PHE A C   1 
ATOM 249  O O   . PHE A 1 37  ? 81.027  138.387 119.533 1.00 70.49  ? 37  PHE A O   1 
ATOM 250  C CB  . PHE A 1 37  ? 80.037  135.319 119.853 1.00 66.65  ? 37  PHE A CB  1 
ATOM 251  C CG  . PHE A 1 37  ? 80.534  134.877 118.511 1.00 70.29  ? 37  PHE A CG  1 
ATOM 252  C CD1 . PHE A 1 37  ? 80.144  135.533 117.364 1.00 72.22  ? 37  PHE A CD1 1 
ATOM 253  C CD2 . PHE A 1 37  ? 81.401  133.802 118.404 1.00 67.79  ? 37  PHE A CD2 1 
ATOM 254  C CE1 . PHE A 1 37  ? 80.607  135.130 116.130 1.00 73.17  ? 37  PHE A CE1 1 
ATOM 255  C CE2 . PHE A 1 37  ? 81.866  133.390 117.172 1.00 67.84  ? 37  PHE A CE2 1 
ATOM 256  C CZ  . PHE A 1 37  ? 81.467  134.056 116.034 1.00 68.67  ? 37  PHE A CZ  1 
ATOM 257  N N   . ALA A 1 38  ? 79.834  138.193 121.444 1.00 66.39  ? 38  ALA A N   1 
ATOM 258  C CA  . ALA A 1 38  ? 79.557  139.626 121.507 1.00 69.77  ? 38  ALA A CA  1 
ATOM 259  C C   . ALA A 1 38  ? 80.832  140.422 121.763 1.00 71.37  ? 38  ALA A C   1 
ATOM 260  O O   . ALA A 1 38  ? 81.045  141.482 121.161 1.00 68.21  ? 38  ALA A O   1 
ATOM 261  C CB  . ALA A 1 38  ? 78.515  139.913 122.586 1.00 67.69  ? 38  ALA A CB  1 
ATOM 262  N N   . GLY A 1 39  ? 81.700  139.918 122.644 1.00 65.80  ? 39  GLY A N   1 
ATOM 263  C CA  . GLY A 1 39  ? 82.993  140.548 122.840 1.00 54.43  ? 39  GLY A CA  1 
ATOM 264  C C   . GLY A 1 39  ? 83.864  140.490 121.600 1.00 52.81  ? 39  GLY A C   1 
ATOM 265  O O   . GLY A 1 39  ? 84.614  141.425 121.323 1.00 57.01  ? 39  GLY A O   1 
ATOM 266  N N   . VAL A 1 40  ? 83.772  139.395 120.838 1.00 55.54  ? 40  VAL A N   1 
ATOM 267  C CA  . VAL A 1 40  ? 84.547  139.265 119.604 1.00 54.09  ? 40  VAL A CA  1 
ATOM 268  C C   . VAL A 1 40  ? 84.131  140.326 118.592 1.00 53.86  ? 40  VAL A C   1 
ATOM 269  O O   . VAL A 1 40  ? 84.982  141.034 118.028 1.00 54.05  ? 40  VAL A O   1 
ATOM 270  C CB  . VAL A 1 40  ? 84.402  137.844 119.027 1.00 48.70  ? 40  VAL A CB  1 
ATOM 271  C CG1 . VAL A 1 40  ? 84.685  137.829 117.533 1.00 46.23  ? 40  VAL A CG1 1 
ATOM 272  C CG2 . VAL A 1 40  ? 85.335  136.885 119.734 1.00 51.59  ? 40  VAL A CG2 1 
ATOM 273  N N   . ARG A 1 41  ? 82.821  140.477 118.365 1.00 48.44  ? 41  ARG A N   1 
ATOM 274  C CA  . ARG A 1 41  ? 82.375  141.477 117.397 1.00 52.13  ? 41  ARG A CA  1 
ATOM 275  C C   . ARG A 1 41  ? 82.644  142.894 117.900 1.00 56.15  ? 41  ARG A C   1 
ATOM 276  O O   . ARG A 1 41  ? 83.012  143.777 117.111 1.00 56.20  ? 41  ARG A O   1 
ATOM 277  C CB  . ARG A 1 41  ? 80.897  141.277 117.042 1.00 57.10  ? 41  ARG A CB  1 
ATOM 278  C CG  . ARG A 1 41  ? 79.923  141.198 118.201 1.00 53.86  ? 41  ARG A CG  1 
ATOM 279  C CD  . ARG A 1 41  ? 79.276  142.542 118.512 1.00 55.23  ? 41  ARG A CD  1 
ATOM 280  N NE  . ARG A 1 41  ? 78.074  142.400 119.325 1.00 55.69  ? 41  ARG A NE  1 
ATOM 281  C CZ  . ARG A 1 41  ? 77.333  143.414 119.749 1.00 56.23  ? 41  ARG A CZ  1 
ATOM 282  N NH1 . ARG A 1 41  ? 77.646  144.667 119.461 1.00 56.13  ? 41  ARG A NH1 1 
ATOM 283  N NH2 . ARG A 1 41  ? 76.252  143.166 120.484 1.00 56.18  ? 41  ARG A NH2 1 
ATOM 284  N N   . GLU A 1 42  ? 82.516  143.118 119.216 1.00 58.17  ? 42  GLU A N   1 
ATOM 285  C CA  . GLU A 1 42  ? 82.810  144.434 119.779 1.00 59.82  ? 42  GLU A CA  1 
ATOM 286  C C   . GLU A 1 42  ? 84.285  144.791 119.637 1.00 54.04  ? 42  GLU A C   1 
ATOM 287  O O   . GLU A 1 42  ? 84.617  145.926 119.276 1.00 51.17  ? 42  GLU A O   1 
ATOM 288  C CB  . GLU A 1 42  ? 82.391  144.481 121.248 1.00 58.03  ? 42  GLU A CB  1 
ATOM 289  C CG  . GLU A 1 42  ? 82.015  145.869 121.735 1.00 53.91  ? 42  GLU A CG  1 
ATOM 290  C CD  . GLU A 1 42  ? 83.218  146.680 122.165 1.00 56.27  ? 42  GLU A CD  1 
ATOM 291  O OE1 . GLU A 1 42  ? 84.018  146.170 122.977 1.00 55.27  ? 42  GLU A OE1 1 
ATOM 292  O OE2 . GLU A 1 42  ? 83.368  147.824 121.687 1.00 57.35  ? 42  GLU A OE2 1 
ATOM 293  N N   . GLN A 1 43  ? 85.182  143.837 119.908 1.00 55.77  ? 43  GLN A N   1 
ATOM 294  C CA  . GLN A 1 43  ? 86.612  144.098 119.787 1.00 49.51  ? 43  GLN A CA  1 
ATOM 295  C C   . GLN A 1 43  ? 87.015  144.342 118.340 1.00 49.82  ? 43  GLN A C   1 
ATOM 296  O O   . GLN A 1 43  ? 87.818  145.240 118.068 1.00 52.14  ? 43  GLN A O   1 
ATOM 297  C CB  . GLN A 1 43  ? 87.419  142.941 120.376 1.00 38.80  ? 43  GLN A CB  1 
ATOM 298  C CG  . GLN A 1 43  ? 87.425  142.887 121.892 1.00 49.09  ? 43  GLN A CG  1 
ATOM 299  C CD  . GLN A 1 43  ? 87.562  144.250 122.527 1.00 51.58  ? 43  GLN A CD  1 
ATOM 300  O OE1 . GLN A 1 43  ? 88.570  144.928 122.352 0.28 50.89  ? 43  GLN A OE1 1 
ATOM 301  N NE2 . GLN A 1 43  ? 86.545  144.662 123.270 1.00 53.76  ? 43  GLN A NE2 1 
ATOM 302  N N   . ALA A 1 44  ? 86.463  143.570 117.396 1.00 61.20  ? 44  ALA A N   1 
ATOM 303  C CA  . ALA A 1 44  ? 86.780  143.801 115.987 1.00 56.78  ? 44  ALA A CA  1 
ATOM 304  C C   . ALA A 1 44  ? 86.298  145.175 115.525 1.00 55.79  ? 44  ALA A C   1 
ATOM 305  O O   . ALA A 1 44  ? 87.049  145.926 114.879 1.00 57.50  ? 44  ALA A O   1 
ATOM 306  C CB  . ALA A 1 44  ? 86.169  142.700 115.123 1.00 56.69  ? 44  ALA A CB  1 
ATOM 307  N N   . LEU A 1 45  ? 85.058  145.534 115.879 1.00 50.09  ? 45  LEU A N   1 
ATOM 308  C CA  . LEU A 1 45  ? 84.500  146.808 115.438 1.00 56.87  ? 45  LEU A CA  1 
ATOM 309  C C   . LEU A 1 45  ? 85.211  147.992 116.085 1.00 64.25  ? 45  LEU A C   1 
ATOM 310  O O   . LEU A 1 45  ? 85.402  149.031 115.442 1.00 63.90  ? 45  LEU A O   1 
ATOM 311  C CB  . LEU A 1 45  ? 83.001  146.848 115.732 1.00 58.16  ? 45  LEU A CB  1 
ATOM 312  C CG  . LEU A 1 45  ? 82.098  147.459 114.657 1.00 57.50  ? 45  LEU A CG  1 
ATOM 313  C CD1 . LEU A 1 45  ? 82.558  147.073 113.257 1.00 61.68  ? 45  LEU A CD1 1 
ATOM 314  C CD2 . LEU A 1 45  ? 80.654  147.037 114.881 1.00 56.84  ? 45  LEU A CD2 1 
ATOM 315  N N   . GLY A 1 46  ? 85.609  147.863 117.354 1.00 64.68  ? 46  GLY A N   1 
ATOM 316  C CA  . GLY A 1 46  ? 86.341  148.934 118.005 1.00 60.29  ? 46  GLY A CA  1 
ATOM 317  C C   . GLY A 1 46  ? 87.803  149.011 117.620 1.00 60.95  ? 46  GLY A C   1 
ATOM 318  O O   . GLY A 1 46  ? 88.415  150.074 117.766 1.00 60.56  ? 46  GLY A O   1 
ATOM 319  N N   . LEU A 1 47  ? 88.377  147.915 117.127 1.00 61.70  ? 47  LEU A N   1 
ATOM 320  C CA  . LEU A 1 47  ? 89.778  147.904 116.746 1.00 49.16  ? 47  LEU A CA  1 
ATOM 321  C C   . LEU A 1 47  ? 90.005  148.285 115.292 1.00 54.67  ? 47  LEU A C   1 
ATOM 322  O O   . LEU A 1 47  ? 91.141  148.605 114.929 1.00 56.66  ? 47  LEU A O   1 
ATOM 323  C CB  . LEU A 1 47  ? 90.376  146.517 117.007 1.00 45.45  ? 47  LEU A CB  1 
ATOM 324  C CG  . LEU A 1 47  ? 91.875  146.418 117.287 1.00 50.38  ? 47  LEU A CG  1 
ATOM 325  C CD1 . LEU A 1 47  ? 92.369  147.641 118.037 1.00 59.64  ? 47  LEU A CD1 1 
ATOM 326  C CD2 . LEU A 1 47  ? 92.191  145.153 118.061 1.00 52.07  ? 47  LEU A CD2 1 
ATOM 327  N N   . GLU A 1 48  ? 88.964  148.243 114.456 1.00 66.93  ? 48  GLU A N   1 
ATOM 328  C CA  . GLU A 1 48  ? 89.113  148.657 113.057 1.00 68.46  ? 48  GLU A CA  1 
ATOM 329  C C   . GLU A 1 48  ? 89.635  150.088 112.845 1.00 74.83  ? 48  GLU A C   1 
ATOM 330  O O   . GLU A 1 48  ? 90.594  150.250 112.064 1.00 74.33  ? 48  GLU A O   1 
ATOM 331  C CB  . GLU A 1 48  ? 87.781  148.435 112.328 1.00 67.51  ? 48  GLU A CB  1 
ATOM 332  C CG  . GLU A 1 48  ? 87.590  149.278 111.079 1.00 71.06  ? 48  GLU A CG  1 
ATOM 333  C CD  . GLU A 1 48  ? 86.201  149.135 110.492 1.00 69.00  ? 48  GLU A CD  1 
ATOM 334  O OE1 . GLU A 1 48  ? 85.743  147.986 110.318 1.00 68.82  ? 48  GLU A OE1 1 
ATOM 335  O OE2 . GLU A 1 48  ? 85.565  150.172 110.206 1.00 63.62  ? 48  GLU A OE2 1 
ATOM 336  N N   . PRO A 1 49  ? 89.096  151.151 113.478 1.00 69.46  ? 49  PRO A N   1 
ATOM 337  C CA  . PRO A 1 49  ? 89.559  152.502 113.098 1.00 65.40  ? 49  PRO A CA  1 
ATOM 338  C C   . PRO A 1 49  ? 90.966  152.835 113.572 1.00 64.17  ? 49  PRO A C   1 
ATOM 339  O O   . PRO A 1 49  ? 91.691  153.550 112.863 1.00 64.24  ? 49  PRO A O   1 
ATOM 340  C CB  . PRO A 1 49  ? 88.517  153.425 113.742 1.00 65.95  ? 49  PRO A CB  1 
ATOM 341  C CG  . PRO A 1 49  ? 88.059  152.686 114.923 1.00 64.39  ? 49  PRO A CG  1 
ATOM 342  C CD  . PRO A 1 49  ? 88.038  151.243 114.510 1.00 61.67  ? 49  PRO A CD  1 
ATOM 343  N N   . ALA A 1 50  ? 91.370  152.346 114.748 1.00 64.71  ? 50  ALA A N   1 
ATOM 344  C CA  . ALA A 1 50  ? 92.734  152.564 115.214 1.00 60.62  ? 50  ALA A CA  1 
ATOM 345  C C   . ALA A 1 50  ? 93.739  151.889 114.291 1.00 56.70  ? 50  ALA A C   1 
ATOM 346  O O   . ALA A 1 50  ? 94.797  152.455 113.991 1.00 60.02  ? 50  ALA A O   1 
ATOM 347  C CB  . ALA A 1 50  ? 92.881  152.058 116.647 1.00 58.46  ? 50  ALA A CB  1 
ATOM 348  N N   . LEU A 1 51  ? 93.406  150.688 113.807 1.00 52.10  ? 51  LEU A N   1 
ATOM 349  C CA  . LEU A 1 51  ? 94.251  150.013 112.827 1.00 59.21  ? 51  LEU A CA  1 
ATOM 350  C C   . LEU A 1 51  ? 94.315  150.789 111.517 1.00 58.24  ? 51  LEU A C   1 
ATOM 351  O O   . LEU A 1 51  ? 95.370  150.842 110.874 1.00 63.65  ? 51  LEU A O   1 
ATOM 352  C CB  . LEU A 1 51  ? 93.740  148.594 112.577 1.00 59.15  ? 51  LEU A CB  1 
ATOM 353  C CG  . LEU A 1 51  ? 93.971  147.551 113.671 1.00 58.87  ? 51  LEU A CG  1 
ATOM 354  C CD1 . LEU A 1 51  ? 93.644  146.161 113.146 1.00 61.02  ? 51  LEU A CD1 1 
ATOM 355  C CD2 . LEU A 1 51  ? 95.388  147.620 114.214 1.00 54.25  ? 51  LEU A CD2 1 
ATOM 356  N N   . GLY A 1 52  ? 93.195  151.392 111.103 1.00 66.25  ? 52  GLY A N   1 
ATOM 357  C CA  . GLY A 1 52  ? 93.212  152.201 109.889 1.00 72.46  ? 52  GLY A CA  1 
ATOM 358  C C   . GLY A 1 52  ? 94.119  153.415 109.999 1.00 70.13  ? 52  GLY A C   1 
ATOM 359  O O   . GLY A 1 52  ? 94.902  153.710 109.086 1.00 65.71  ? 52  GLY A O   1 
ATOM 360  N N   . ARG A 1 53  ? 94.031  154.130 111.127 1.00 66.76  ? 53  ARG A N   1 
ATOM 361  C CA  . ARG A 1 53  ? 94.922  155.270 111.353 1.00 68.49  ? 53  ARG A CA  1 
ATOM 362  C C   . ARG A 1 53  ? 96.381  154.830 111.417 1.00 67.47  ? 53  ARG A C   1 
ATOM 363  O O   . ARG A 1 53  ? 97.269  155.507 110.874 1.00 69.06  ? 53  ARG A O   1 
ATOM 364  C CB  . ARG A 1 53  ? 94.545  156.008 112.638 1.00 66.18  ? 53  ARG A CB  1 
ATOM 365  C CG  . ARG A 1 53  ? 93.102  156.466 112.733 1.00 63.94  ? 53  ARG A CG  1 
ATOM 366  C CD  . ARG A 1 53  ? 92.755  156.815 114.174 1.00 64.78  ? 53  ARG A CD  1 
ATOM 367  N NE  . ARG A 1 53  ? 91.476  156.254 114.592 1.00 64.21  ? 53  ARG A NE  1 
ATOM 368  C CZ  . ARG A 1 53  ? 91.062  156.193 115.850 1.00 64.21  ? 53  ARG A CZ  1 
ATOM 369  N NH1 . ARG A 1 53  ? 91.803  156.652 116.845 1.00 63.99  ? 53  ARG A NH1 1 
ATOM 370  N NH2 . ARG A 1 53  ? 89.875  155.655 116.117 1.00 67.94  ? 53  ARG A NH2 1 
ATOM 371  N N   . LEU A 1 54  ? 96.642  153.693 112.075 1.00 55.74  ? 54  LEU A N   1 
ATOM 372  C CA  . LEU A 1 54  ? 98.005  153.184 112.181 1.00 46.00  ? 54  LEU A CA  1 
ATOM 373  C C   . LEU A 1 54  ? 98.582  152.830 110.818 1.00 52.06  ? 54  LEU A C   1 
ATOM 374  O O   . LEU A 1 54  ? 99.737  153.155 110.535 1.00 54.69  ? 54  LEU A O   1 
ATOM 375  C CB  . LEU A 1 54  ? 98.048  151.967 113.104 1.00 45.74  ? 54  LEU A CB  1 
ATOM 376  C CG  . LEU A 1 54  ? 98.408  152.202 114.572 1.00 42.40  ? 54  LEU A CG  1 
ATOM 377  C CD1 . LEU A 1 54  ? 98.922  150.918 115.196 1.00 46.56  ? 54  LEU A CD1 1 
ATOM 378  C CD2 . LEU A 1 54  ? 99.432  153.306 114.720 1.00 48.57  ? 54  LEU A CD2 1 
ATOM 379  N N   . LEU A 1 55  ? 97.797  152.184 109.949 1.00 63.73  ? 55  LEU A N   1 
ATOM 380  C CA  . LEU A 1 55  ? 98.333  151.834 108.635 1.00 65.84  ? 55  LEU A CA  1 
ATOM 381  C C   . LEU A 1 55  ? 98.517  153.063 107.752 1.00 66.36  ? 55  LEU A C   1 
ATOM 382  O O   . LEU A 1 55  ? 99.490  153.128 106.986 1.00 70.73  ? 55  LEU A O   1 
ATOM 383  C CB  . LEU A 1 55  ? 97.452  150.794 107.932 1.00 63.58  ? 55  LEU A CB  1 
ATOM 384  C CG  . LEU A 1 55  ? 95.967  151.011 107.633 1.00 58.27  ? 55  LEU A CG  1 
ATOM 385  C CD1 . LEU A 1 55  ? 95.757  151.549 106.226 1.00 62.14  ? 55  LEU A CD1 1 
ATOM 386  C CD2 . LEU A 1 55  ? 95.207  149.708 107.815 1.00 58.22  ? 55  LEU A CD2 1 
ATOM 387  N N   . GLY A 1 56  ? 97.621  154.052 107.856 1.00 60.33  ? 56  GLY A N   1 
ATOM 388  C CA  . GLY A 1 56  ? 97.805  155.278 107.089 1.00 64.37  ? 56  GLY A CA  1 
ATOM 389  C C   . GLY A 1 56  ? 99.067  156.028 107.477 1.00 66.98  ? 56  GLY A C   1 
ATOM 390  O O   . GLY A 1 56  ? 99.871  156.422 106.620 1.00 62.34  ? 56  GLY A O   1 
ATOM 391  N N   . VAL A 1 57  ? 99.295  156.192 108.780 1.00 62.55  ? 57  VAL A N   1 
ATOM 392  C CA  . VAL A 1 57  ? 100.497 156.916 109.171 1.00 57.53  ? 57  VAL A CA  1 
ATOM 393  C C   . VAL A 1 57  ? 101.739 156.033 109.007 1.00 60.50  ? 57  VAL A C   1 
ATOM 394  O O   . VAL A 1 57  ? 102.834 156.551 108.761 1.00 60.62  ? 57  VAL A O   1 
ATOM 395  C CB  . VAL A 1 57  ? 100.298 157.485 110.590 1.00 57.00  ? 57  VAL A CB  1 
ATOM 396  C CG1 . VAL A 1 57  ? 101.603 157.700 111.305 1.00 61.63  ? 57  VAL A CG1 1 
ATOM 397  C CG2 . VAL A 1 57  ? 99.502  158.782 110.534 1.00 60.56  ? 57  VAL A CG2 1 
ATOM 398  N N   . ALA A 1 58  ? 101.587 154.705 109.040 1.00 58.72  ? 58  ALA A N   1 
ATOM 399  C CA  . ALA A 1 58  ? 102.700 153.812 108.732 1.00 58.40  ? 58  ALA A CA  1 
ATOM 400  C C   . ALA A 1 58  ? 103.147 153.959 107.284 1.00 59.72  ? 58  ALA A C   1 
ATOM 401  O O   . ALA A 1 58  ? 104.345 153.873 106.987 1.00 55.66  ? 58  ALA A O   1 
ATOM 402  C CB  . ALA A 1 58  ? 102.300 152.367 109.020 1.00 57.96  ? 58  ALA A CB  1 
ATOM 403  N N   . HIS A 1 59  ? 102.197 154.156 106.367 1.00 61.80  ? 59  HIS A N   1 
ATOM 404  C CA  . HIS A 1 59  ? 102.566 154.563 105.014 1.00 65.76  ? 59  HIS A CA  1 
ATOM 405  C C   . HIS A 1 59  ? 103.249 155.925 105.027 1.00 68.52  ? 59  HIS A C   1 
ATOM 406  O O   . HIS A 1 59  ? 104.212 156.154 104.284 1.00 67.27  ? 59  HIS A O   1 
ATOM 407  C CB  . HIS A 1 59  ? 101.337 154.593 104.107 1.00 65.21  ? 59  HIS A CB  1 
ATOM 408  C CG  . HIS A 1 59  ? 101.591 155.226 102.774 1.00 62.83  ? 59  HIS A CG  1 
ATOM 409  N ND1 . HIS A 1 59  ? 100.736 156.150 102.214 1.00 60.59  ? 59  HIS A ND1 1 
ATOM 410  C CD2 . HIS A 1 59  ? 102.603 155.066 101.888 1.00 62.85  ? 59  HIS A CD2 1 
ATOM 411  C CE1 . HIS A 1 59  ? 101.212 156.536 101.044 1.00 65.00  ? 59  HIS A CE1 1 
ATOM 412  N NE2 . HIS A 1 59  ? 102.345 155.894 100.823 1.00 62.90  ? 59  HIS A NE2 1 
ATOM 413  N N   . LEU A 1 60  ? 102.765 156.842 105.871 1.00 67.43  ? 60  LEU A N   1 
ATOM 414  C CA  . LEU A 1 60  ? 103.390 158.162 105.990 1.00 62.00  ? 60  LEU A CA  1 
ATOM 415  C C   . LEU A 1 60  ? 104.790 158.120 106.616 1.00 62.32  ? 60  LEU A C   1 
ATOM 416  O O   . LEU A 1 60  ? 105.541 159.093 106.485 1.00 58.16  ? 60  LEU A O   1 
ATOM 417  C CB  . LEU A 1 60  ? 102.473 159.088 106.800 1.00 61.36  ? 60  LEU A CB  1 
ATOM 418  C CG  . LEU A 1 60  ? 102.615 160.613 106.755 1.00 62.04  ? 60  LEU A CG  1 
ATOM 419  C CD1 . LEU A 1 60  ? 101.240 161.254 106.807 1.00 62.93  ? 60  LEU A CD1 1 
ATOM 420  C CD2 . LEU A 1 60  ? 103.461 161.122 107.915 1.00 60.53  ? 60  LEU A CD2 1 
ATOM 421  N N   . PHE A 1 61  ? 105.171 157.016 107.259 1.00 58.50  ? 61  PHE A N   1 
ATOM 422  C CA  . PHE A 1 61  ? 106.306 156.985 108.174 1.00 62.87  ? 61  PHE A CA  1 
ATOM 423  C C   . PHE A 1 61  ? 107.549 156.302 107.623 1.00 66.86  ? 61  PHE A C   1 
ATOM 424  O O   . PHE A 1 61  ? 108.655 156.641 108.046 1.00 66.94  ? 61  PHE A O   1 
ATOM 425  C CB  . PHE A 1 61  ? 105.904 156.272 109.471 1.00 64.44  ? 61  PHE A CB  1 
ATOM 426  C CG  . PHE A 1 61  ? 106.295 157.004 110.720 1.00 61.57  ? 61  PHE A CG  1 
ATOM 427  C CD1 . PHE A 1 61  ? 107.422 156.638 111.434 1.00 57.64  ? 61  PHE A CD1 1 
ATOM 428  C CD2 . PHE A 1 61  ? 105.515 158.043 111.195 1.00 59.81  ? 61  PHE A CD2 1 
ATOM 429  C CE1 . PHE A 1 61  ? 107.770 157.309 112.591 1.00 57.12  ? 61  PHE A CE1 1 
ATOM 430  C CE2 . PHE A 1 61  ? 105.859 158.713 112.351 1.00 59.71  ? 61  PHE A CE2 1 
ATOM 431  C CZ  . PHE A 1 61  ? 106.988 158.347 113.049 1.00 59.78  ? 61  PHE A CZ  1 
ATOM 432  N N   . ASP A 1 62  ? 107.399 155.345 106.709 1.00 64.20  ? 62  ASP A N   1 
ATOM 433  C CA  . ASP A 1 62  ? 108.510 154.492 106.307 1.00 63.18  ? 62  ASP A CA  1 
ATOM 434  C C   . ASP A 1 62  ? 109.516 155.246 105.440 1.00 63.19  ? 62  ASP A C   1 
ATOM 435  O O   . ASP A 1 62  ? 109.194 156.231 104.769 1.00 64.99  ? 62  ASP A O   1 
ATOM 436  C CB  . ASP A 1 62  ? 108.000 153.262 105.554 1.00 64.68  ? 62  ASP A CB  1 
ATOM 437  C CG  . ASP A 1 62  ? 108.985 152.107 105.589 1.00 65.10  ? 62  ASP A CG  1 
ATOM 438  O OD1 . ASP A 1 62  ? 110.058 152.220 104.960 1.00 66.72  ? 62  ASP A OD1 1 
ATOM 439  O OD2 . ASP A 1 62  ? 108.689 151.086 106.244 1.00 64.61  ? 62  ASP A OD2 1 
ATOM 440  N N   . LEU A 1 63  ? 110.758 154.756 105.465 1.00 71.97  ? 63  LEU A N   1 
ATOM 441  C CA  . LEU A 1 63  ? 111.844 155.390 104.726 1.00 71.95  ? 63  LEU A CA  1 
ATOM 442  C C   . LEU A 1 63  ? 111.728 155.148 103.223 1.00 71.68  ? 63  LEU A C   1 
ATOM 443  O O   . LEU A 1 63  ? 111.882 156.081 102.427 1.00 67.98  ? 63  LEU A O   1 
ATOM 444  C CB  . LEU A 1 63  ? 113.193 154.908 105.278 1.00 69.12  ? 63  LEU A CB  1 
ATOM 445  C CG  . LEU A 1 63  ? 113.577 153.422 105.312 1.00 65.83  ? 63  LEU A CG  1 
ATOM 446  C CD1 . LEU A 1 63  ? 114.419 153.024 104.108 1.00 71.98  ? 63  LEU A CD1 1 
ATOM 447  C CD2 . LEU A 1 63  ? 114.298 153.082 106.608 1.00 64.44  ? 63  LEU A CD2 1 
ATOM 448  N N   . ASP A 1 64  ? 111.443 153.915 102.814 1.00 84.04  ? 64  ASP A N   1 
ATOM 449  C CA  . ASP A 1 64  ? 111.327 153.566 101.407 1.00 85.80  ? 64  ASP A CA  1 
ATOM 450  C C   . ASP A 1 64  ? 110.090 152.712 101.180 1.00 84.97  ? 64  ASP A C   1 
ATOM 451  O O   . ASP A 1 64  ? 109.690 151.945 102.062 1.00 80.19  ? 64  ASP A O   1 
ATOM 452  C CB  . ASP A 1 64  ? 112.566 152.802 100.911 1.00 83.23  ? 64  ASP A CB  1 
ATOM 453  C CG  . ASP A 1 64  ? 113.689 153.722 100.465 1.00 79.45  ? 64  ASP A CG  1 
ATOM 454  O OD1 . ASP A 1 64  ? 114.050 154.647 101.221 1.00 80.18  ? 64  ASP A OD1 1 
ATOM 455  O OD2 . ASP A 1 64  ? 114.209 153.522 99.347  1.00 76.97  ? 64  ASP A OD2 1 
ATOM 456  N N   . PRO A 1 65  ? 109.460 152.826 100.006 1.00 87.02  ? 65  PRO A N   1 
ATOM 457  C CA  . PRO A 1 65  ? 108.329 151.937 99.697  1.00 85.83  ? 65  PRO A CA  1 
ATOM 458  C C   . PRO A 1 65  ? 108.733 150.489 99.482  1.00 82.80  ? 65  PRO A C   1 
ATOM 459  O O   . PRO A 1 65  ? 107.876 149.604 99.596  1.00 82.23  ? 65  PRO A O   1 
ATOM 460  C CB  . PRO A 1 65  ? 107.740 152.543 98.416  1.00 85.53  ? 65  PRO A CB  1 
ATOM 461  C CG  . PRO A 1 65  ? 108.851 153.328 97.815  1.00 84.88  ? 65  PRO A CG  1 
ATOM 462  C CD  . PRO A 1 65  ? 109.675 153.838 98.957  1.00 85.65  ? 65  PRO A CD  1 
ATOM 463  N N   . GLU A 1 66  ? 110.004 150.220 99.175  1.00 87.99  ? 66  GLU A N   1 
ATOM 464  C CA  . GLU A 1 66  ? 110.425 148.853 98.889  1.00 91.48  ? 66  GLU A CA  1 
ATOM 465  C C   . GLU A 1 66  ? 110.471 147.995 100.146 1.00 91.59  ? 66  GLU A C   1 
ATOM 466  O O   . GLU A 1 66  ? 110.222 146.787 100.077 1.00 89.08  ? 66  GLU A O   1 
ATOM 467  C CB  . GLU A 1 66  ? 111.790 148.858 98.202  1.00 91.26  ? 66  GLU A CB  1 
ATOM 468  C CG  . GLU A 1 66  ? 111.968 149.982 97.196  1.00 91.28  ? 66  GLU A CG  1 
ATOM 469  C CD  . GLU A 1 66  ? 113.418 150.191 96.806  1.00 88.96  ? 66  GLU A CD  1 
ATOM 470  O OE1 . GLU A 1 66  ? 114.263 149.349 97.176  1.00 88.99  ? 66  GLU A OE1 1 
ATOM 471  O OE2 . GLU A 1 66  ? 113.712 151.198 96.129  1.00 85.02  ? 66  GLU A OE2 1 
ATOM 472  N N   . THR A 1 67  ? 110.784 148.590 101.294 1.00 87.12  ? 67  THR A N   1 
ATOM 473  C CA  . THR A 1 67  ? 110.919 147.844 102.545 1.00 86.07  ? 67  THR A CA  1 
ATOM 474  C C   . THR A 1 67  ? 109.844 148.278 103.528 1.00 86.45  ? 67  THR A C   1 
ATOM 475  O O   . THR A 1 67  ? 109.987 149.322 104.189 1.00 81.41  ? 67  THR A O   1 
ATOM 476  C CB  . THR A 1 67  ? 112.305 148.048 103.151 1.00 82.25  ? 67  THR A CB  1 
ATOM 477  O OG1 . THR A 1 67  ? 112.578 149.449 103.259 1.00 83.09  ? 67  THR A OG1 1 
ATOM 478  C CG2 . THR A 1 67  ? 113.357 147.405 102.270 1.00 81.28  ? 67  THR A CG2 1 
ATOM 479  N N   . PRO A 1 68  ? 108.754 147.522 103.663 1.00 87.92  ? 68  PRO A N   1 
ATOM 480  C CA  . PRO A 1 68  ? 107.761 147.842 104.697 1.00 85.12  ? 68  PRO A CA  1 
ATOM 481  C C   . PRO A 1 68  ? 108.262 147.452 106.076 1.00 82.72  ? 68  PRO A C   1 
ATOM 482  O O   . PRO A 1 68  ? 107.836 146.434 106.631 1.00 78.85  ? 68  PRO A O   1 
ATOM 483  C CB  . PRO A 1 68  ? 106.535 147.015 104.294 1.00 80.33  ? 68  PRO A CB  1 
ATOM 484  C CG  . PRO A 1 68  ? 107.035 145.968 103.370 1.00 79.67  ? 68  PRO A CG  1 
ATOM 485  C CD  . PRO A 1 68  ? 108.350 146.396 102.804 1.00 81.21  ? 68  PRO A CD  1 
ATOM 486  N N   . ALA A 1 69  ? 109.168 148.246 106.637 1.00 58.10  ? 69  ALA A N   1 
ATOM 487  C CA  . ALA A 1 69  ? 109.820 147.928 107.902 1.00 56.01  ? 69  ALA A CA  1 
ATOM 488  C C   . ALA A 1 69  ? 109.615 149.092 108.863 1.00 52.69  ? 69  ALA A C   1 
ATOM 489  O O   . ALA A 1 69  ? 110.354 150.076 108.831 1.00 62.52  ? 69  ALA A O   1 
ATOM 490  C CB  . ALA A 1 69  ? 111.299 147.634 107.688 1.00 61.59  ? 69  ALA A CB  1 
ATOM 491  N N   . ASN A 1 70  ? 108.588 148.982 109.701 1.00 47.45  ? 70  ASN A N   1 
ATOM 492  C CA  . ASN A 1 70  ? 108.362 149.892 110.814 1.00 53.47  ? 70  ASN A CA  1 
ATOM 493  C C   . ASN A 1 70  ? 107.782 149.087 111.965 1.00 59.42  ? 70  ASN A C   1 
ATOM 494  O O   . ASN A 1 70  ? 107.462 147.906 111.817 1.00 55.95  ? 70  ASN A O   1 
ATOM 495  C CB  . ASN A 1 70  ? 107.401 151.044 110.467 1.00 56.55  ? 70  ASN A CB  1 
ATOM 496  C CG  . ASN A 1 70  ? 107.713 151.702 109.139 1.00 57.01  ? 70  ASN A CG  1 
ATOM 497  O OD1 . ASN A 1 70  ? 108.464 152.674 109.074 1.00 59.11  ? 70  ASN A OD1 1 
ATOM 498  N ND2 . ASN A 1 70  ? 107.134 151.173 108.069 1.00 57.62  ? 70  ASN A ND2 1 
ATOM 499  N N   . GLY A 1 71  ? 107.641 149.734 113.121 1.00 60.72  ? 71  GLY A N   1 
ATOM 500  C CA  . GLY A 1 71  ? 106.928 149.099 114.216 1.00 64.04  ? 71  GLY A CA  1 
ATOM 501  C C   . GLY A 1 71  ? 105.426 149.109 114.024 1.00 60.48  ? 71  GLY A C   1 
ATOM 502  O O   . GLY A 1 71  ? 104.728 148.193 114.480 1.00 59.45  ? 71  GLY A O   1 
ATOM 503  N N   . TYR A 1 72  ? 104.910 150.138 113.346 1.00 47.84  ? 72  TYR A N   1 
ATOM 504  C CA  . TYR A 1 72  ? 103.475 150.247 113.111 1.00 51.95  ? 72  TYR A CA  1 
ATOM 505  C C   . TYR A 1 72  ? 102.971 149.117 112.225 1.00 49.79  ? 72  TYR A C   1 
ATOM 506  O O   . TYR A 1 72  ? 101.912 148.534 112.493 1.00 52.44  ? 72  TYR A O   1 
ATOM 507  C CB  . TYR A 1 72  ? 103.161 151.605 112.487 1.00 55.01  ? 72  TYR A CB  1 
ATOM 508  C CG  . TYR A 1 72  ? 103.576 152.765 113.351 1.00 49.88  ? 72  TYR A CG  1 
ATOM 509  C CD1 . TYR A 1 72  ? 103.134 152.864 114.660 1.00 54.98  ? 72  TYR A CD1 1 
ATOM 510  C CD2 . TYR A 1 72  ? 104.417 153.753 112.865 1.00 51.92  ? 72  TYR A CD2 1 
ATOM 511  C CE1 . TYR A 1 72  ? 103.507 153.918 115.462 1.00 56.14  ? 72  TYR A CE1 1 
ATOM 512  C CE2 . TYR A 1 72  ? 104.802 154.814 113.661 1.00 57.81  ? 72  TYR A CE2 1 
ATOM 513  C CZ  . TYR A 1 72  ? 104.341 154.890 114.960 1.00 56.88  ? 72  TYR A CZ  1 
ATOM 514  O OH  . TYR A 1 72  ? 104.717 155.935 115.771 1.00 57.58  ? 72  TYR A OH  1 
ATOM 515  N N   . ARG A 1 73  ? 103.723 148.791 111.169 1.00 44.26  ? 73  ARG A N   1 
ATOM 516  C CA  . ARG A 1 73  ? 103.362 147.664 110.319 1.00 48.82  ? 73  ARG A CA  1 
ATOM 517  C C   . ARG A 1 73  ? 103.390 146.357 111.092 1.00 44.67  ? 73  ARG A C   1 
ATOM 518  O O   . ARG A 1 73  ? 102.562 145.477 110.846 1.00 50.83  ? 73  ARG A O   1 
ATOM 519  C CB  . ARG A 1 73  ? 104.302 147.583 109.118 1.00 48.73  ? 73  ARG A CB  1 
ATOM 520  C CG  . ARG A 1 73  ? 104.571 148.916 108.457 1.00 51.15  ? 73  ARG A CG  1 
ATOM 521  C CD  . ARG A 1 73  ? 103.566 149.206 107.368 1.00 54.42  ? 73  ARG A CD  1 
ATOM 522  N NE  . ARG A 1 73  ? 103.870 150.455 106.683 1.00 60.79  ? 73  ARG A NE  1 
ATOM 523  C CZ  . ARG A 1 73  ? 104.199 150.547 105.403 1.00 60.09  ? 73  ARG A CZ  1 
ATOM 524  N NH1 . ARG A 1 73  ? 104.270 149.477 104.630 1.00 55.40  ? 73  ARG A NH1 1 
ATOM 525  N NH2 . ARG A 1 73  ? 104.461 151.743 104.885 1.00 55.74  ? 73  ARG A NH2 1 
ATOM 526  N N   . SER A 1 74  ? 104.299 146.230 112.060 1.00 35.43  ? 74  SER A N   1 
ATOM 527  C CA  . SER A 1 74  ? 104.374 145.005 112.847 1.00 42.61  ? 74  SER A CA  1 
ATOM 528  C C   . SER A 1 74  ? 103.185 144.867 113.793 1.00 48.24  ? 74  SER A C   1 
ATOM 529  O O   . SER A 1 74  ? 102.625 143.772 113.937 1.00 46.00  ? 74  SER A O   1 
ATOM 530  C CB  . SER A 1 74  ? 105.687 144.966 113.622 1.00 43.17  ? 74  SER A CB  1 
ATOM 531  O OG  . SER A 1 74  ? 105.915 143.676 114.157 1.00 55.85  ? 74  SER A OG  1 
ATOM 532  N N   . LEU A 1 75  ? 102.778 145.962 114.446 1.00 47.88  ? 75  LEU A N   1 
ATOM 533  C CA  . LEU A 1 75  ? 101.614 145.884 115.329 1.00 50.14  ? 75  LEU A CA  1 
ATOM 534  C C   . LEU A 1 75  ? 100.328 145.648 114.542 1.00 44.15  ? 75  LEU A C   1 
ATOM 535  O O   . LEU A 1 75  ? 99.462  144.871 114.973 1.00 39.71  ? 75  LEU A O   1 
ATOM 536  C CB  . LEU A 1 75  ? 101.505 147.148 116.178 1.00 47.86  ? 75  LEU A CB  1 
ATOM 537  C CG  . LEU A 1 75  ? 102.107 147.006 117.577 1.00 48.13  ? 75  LEU A CG  1 
ATOM 538  C CD1 . LEU A 1 75  ? 102.112 148.341 118.295 1.00 50.26  ? 75  LEU A CD1 1 
ATOM 539  C CD2 . LEU A 1 75  ? 101.360 145.962 118.388 1.00 34.70  ? 75  LEU A CD2 1 
ATOM 540  N N   . VAL A 1 76  ? 100.192 146.294 113.379 1.00 46.06  ? 76  VAL A N   1 
ATOM 541  C CA  . VAL A 1 76  ? 99.046  146.044 112.510 1.00 39.40  ? 76  VAL A CA  1 
ATOM 542  C C   . VAL A 1 76  ? 99.046  144.600 112.014 1.00 40.78  ? 76  VAL A C   1 
ATOM 543  O O   . VAL A 1 76  ? 97.986  143.963 111.937 1.00 51.25  ? 76  VAL A O   1 
ATOM 544  C CB  . VAL A 1 76  ? 99.051  147.065 111.353 1.00 44.43  ? 76  VAL A CB  1 
ATOM 545  C CG1 . VAL A 1 76  ? 98.136  146.638 110.216 1.00 41.20  ? 76  VAL A CG1 1 
ATOM 546  C CG2 . VAL A 1 76  ? 98.655  148.442 111.867 1.00 39.90  ? 76  VAL A CG2 1 
ATOM 547  N N   . HIS A 1 77  ? 100.227 144.050 111.708 1.00 35.00  ? 77  HIS A N   1 
ATOM 548  C CA  . HIS A 1 77  ? 100.338 142.655 111.294 1.00 32.27  ? 77  HIS A CA  1 
ATOM 549  C C   . HIS A 1 77  ? 99.905  141.704 112.399 1.00 37.52  ? 77  HIS A C   1 
ATOM 550  O O   . HIS A 1 77  ? 99.200  140.723 112.138 1.00 43.58  ? 77  HIS A O   1 
ATOM 551  C CB  . HIS A 1 77  ? 101.774 142.353 110.878 1.00 43.55  ? 77  HIS A CB  1 
ATOM 552  C CG  . HIS A 1 77  ? 101.887 141.342 109.784 1.00 45.61  ? 77  HIS A CG  1 
ATOM 553  N ND1 . HIS A 1 77  ? 101.657 141.650 108.461 1.00 43.58  ? 77  HIS A ND1 1 
ATOM 554  C CD2 . HIS A 1 77  ? 102.210 140.028 109.815 1.00 49.87  ? 77  HIS A CD2 1 
ATOM 555  C CE1 . HIS A 1 77  ? 101.833 140.569 107.723 1.00 48.27  ? 77  HIS A CE1 1 
ATOM 556  N NE2 . HIS A 1 77  ? 102.169 139.571 108.520 1.00 53.75  ? 77  HIS A NE2 1 
ATOM 557  N N   . THR A 1 78  ? 100.318 141.980 113.638 1.00 32.92  ? 78  THR A N   1 
ATOM 558  C CA  . THR A 1 78  ? 99.909  141.150 114.769 1.00 41.31  ? 78  THR A CA  1 
ATOM 559  C C   . THR A 1 78  ? 98.396  141.199 114.978 1.00 50.14  ? 78  THR A C   1 
ATOM 560  O O   . THR A 1 78  ? 97.749  140.157 115.184 1.00 54.90  ? 78  THR A O   1 
ATOM 561  C CB  . THR A 1 78  ? 100.655 141.604 116.023 1.00 39.47  ? 78  THR A CB  1 
ATOM 562  O OG1 . THR A 1 78  ? 102.057 141.673 115.738 1.00 40.19  ? 78  THR A OG1 1 
ATOM 563  C CG2 . THR A 1 78  ? 100.440 140.644 117.162 1.00 40.97  ? 78  THR A CG2 1 
ATOM 564  N N   . ALA A 1 79  ? 97.811  142.397 114.881 1.00 42.21  ? 79  ALA A N   1 
ATOM 565  C CA  . ALA A 1 79  ? 96.367  142.541 115.054 1.00 30.77  ? 79  ALA A CA  1 
ATOM 566  C C   . ALA A 1 79  ? 95.592  141.816 113.959 1.00 33.14  ? 79  ALA A C   1 
ATOM 567  O O   . ALA A 1 79  ? 94.611  141.116 114.239 1.00 41.64  ? 79  ALA A O   1 
ATOM 568  C CB  . ALA A 1 79  ? 95.991  144.021 115.092 1.00 40.71  ? 79  ALA A CB  1 
ATOM 569  N N   . ARG A 1 80  ? 96.023  141.954 112.702 1.00 40.33  ? 80  ARG A N   1 
ATOM 570  C CA  . ARG A 1 80  ? 95.275  141.303 111.632 1.00 41.11  ? 80  ARG A CA  1 
ATOM 571  C C   . ARG A 1 80  ? 95.515  139.800 111.608 1.00 39.70  ? 80  ARG A C   1 
ATOM 572  O O   . ARG A 1 80  ? 94.642  139.054 111.155 1.00 46.39  ? 80  ARG A O   1 
ATOM 573  C CB  . ARG A 1 80  ? 95.591  141.926 110.269 1.00 40.52  ? 80  ARG A CB  1 
ATOM 574  C CG  . ARG A 1 80  ? 96.990  141.716 109.729 1.00 50.84  ? 80  ARG A CG  1 
ATOM 575  C CD  . ARG A 1 80  ? 97.250  142.693 108.583 1.00 53.42  ? 80  ARG A CD  1 
ATOM 576  N NE  . ARG A 1 80  ? 98.657  143.057 108.465 1.00 57.26  ? 80  ARG A NE  1 
ATOM 577  C CZ  . ARG A 1 80  ? 99.104  144.133 107.832 1.00 59.05  ? 80  ARG A CZ  1 
ATOM 578  N NH1 . ARG A 1 80  ? 98.280  144.969 107.224 1.00 55.63  ? 80  ARG A NH1 1 
ATOM 579  N NH2 . ARG A 1 80  ? 100.411 144.379 107.816 1.00 53.45  ? 80  ARG A NH2 1 
ATOM 580  N N   . CYS A 1 81  ? 96.657  139.326 112.117 1.00 39.69  ? 81  CYS A N   1 
ATOM 581  C CA  . CYS A 1 81  ? 96.839  137.886 112.272 1.00 35.33  ? 81  CYS A CA  1 
ATOM 582  C C   . CYS A 1 81  ? 95.881  137.318 113.310 1.00 43.24  ? 81  CYS A C   1 
ATOM 583  O O   . CYS A 1 81  ? 95.274  136.261 113.087 1.00 59.63  ? 81  CYS A O   1 
ATOM 584  C CB  . CYS A 1 81  ? 98.283  137.569 112.648 1.00 41.18  ? 81  CYS A CB  1 
ATOM 585  S SG  . CYS A 1 81  ? 99.321  137.087 111.252 1.00 63.95  ? 81  CYS A SG  1 
ATOM 586  N N   . CYS A 1 82  ? 95.720  138.017 114.441 1.00 38.64  ? 82  CYS A N   1 
ATOM 587  C CA  . CYS A 1 82  ? 94.743  137.582 115.441 1.00 50.48  ? 82  CYS A CA  1 
ATOM 588  C C   . CYS A 1 82  ? 93.322  137.607 114.880 1.00 50.36  ? 82  CYS A C   1 
ATOM 589  O O   . CYS A 1 82  ? 92.532  136.681 115.120 1.00 41.39  ? 82  CYS A O   1 
ATOM 590  C CB  . CYS A 1 82  ? 94.840  138.460 116.688 1.00 46.44  ? 82  CYS A CB  1 
ATOM 591  S SG  . CYS A 1 82  ? 94.213  137.699 118.196 1.00 27.29  ? 82  CYS A SG  1 
ATOM 592  N N   . LEU A 1 83  ? 92.989  138.652 114.113 1.00 54.96  ? 83  LEU A N   1 
ATOM 593  C CA  . LEU A 1 83  ? 91.658  138.755 113.520 1.00 38.60  ? 83  LEU A CA  1 
ATOM 594  C C   . LEU A 1 83  ? 91.404  137.650 112.499 1.00 41.46  ? 83  LEU A C   1 
ATOM 595  O O   . LEU A 1 83  ? 90.307  137.084 112.458 1.00 45.77  ? 83  LEU A O   1 
ATOM 596  C CB  . LEU A 1 83  ? 91.475  140.128 112.877 1.00 36.09  ? 83  LEU A CB  1 
ATOM 597  C CG  . LEU A 1 83  ? 91.043  141.246 113.826 1.00 39.26  ? 83  LEU A CG  1 
ATOM 598  C CD1 . LEU A 1 83  ? 90.899  142.561 113.078 1.00 45.18  ? 83  LEU A CD1 1 
ATOM 599  C CD2 . LEU A 1 83  ? 89.746  140.878 114.523 1.00 49.00  ? 83  LEU A CD2 1 
ATOM 600  N N   . ALA A 1 84  ? 92.402  137.324 111.672 1.00 48.20  ? 84  ALA A N   1 
ATOM 601  C CA  . ALA A 1 84  ? 92.229  136.266 110.681 1.00 50.79  ? 84  ALA A CA  1 
ATOM 602  C C   . ALA A 1 84  ? 92.106  134.898 111.340 1.00 51.22  ? 84  ALA A C   1 
ATOM 603  O O   . ALA A 1 84  ? 91.339  134.047 110.873 1.00 57.47  ? 84  ALA A O   1 
ATOM 604  C CB  . ALA A 1 84  ? 93.390  136.278 109.688 1.00 50.38  ? 84  ALA A CB  1 
ATOM 605  N N   . HIS A 1 85  ? 92.852  134.669 112.425 1.00 45.28  ? 85  HIS A N   1 
ATOM 606  C CA  . HIS A 1 85  ? 92.724  133.408 113.152 1.00 46.03  ? 85  HIS A CA  1 
ATOM 607  C C   . HIS A 1 85  ? 91.343  133.266 113.787 1.00 45.98  ? 85  HIS A C   1 
ATOM 608  O O   . HIS A 1 85  ? 90.727  132.191 113.722 1.00 48.24  ? 85  HIS A O   1 
ATOM 609  C CB  . HIS A 1 85  ? 93.818  133.310 114.212 1.00 41.06  ? 85  HIS A CB  1 
ATOM 610  C CG  . HIS A 1 85  ? 95.063  132.628 113.740 1.00 46.20  ? 85  HIS A CG  1 
ATOM 611  N ND1 . HIS A 1 85  ? 95.868  131.888 114.578 1.00 55.36  ? 85  HIS A ND1 1 
ATOM 612  C CD2 . HIS A 1 85  ? 95.646  132.581 112.519 1.00 50.38  ? 85  HIS A CD2 1 
ATOM 613  C CE1 . HIS A 1 85  ? 96.891  131.410 113.893 1.00 52.72  ? 85  HIS A CE1 1 
ATOM 614  N NE2 . HIS A 1 85  ? 96.780  131.816 112.641 1.00 47.85  ? 85  HIS A NE2 1 
ATOM 615  N N   . LEU A 1 86  ? 90.834  134.346 114.394 1.00 44.71  ? 86  LEU A N   1 
ATOM 616  C CA  . LEU A 1 86  ? 89.488  134.311 114.964 1.00 46.55  ? 86  LEU A CA  1 
ATOM 617  C C   . LEU A 1 86  ? 88.432  134.127 113.880 1.00 53.32  ? 86  LEU A C   1 
ATOM 618  O O   . LEU A 1 86  ? 87.438  133.422 114.087 1.00 58.01  ? 86  LEU A O   1 
ATOM 619  C CB  . LEU A 1 86  ? 89.221  135.587 115.759 1.00 53.27  ? 86  LEU A CB  1 
ATOM 620  C CG  . LEU A 1 86  ? 89.115  135.437 117.277 1.00 47.77  ? 86  LEU A CG  1 
ATOM 621  C CD1 . LEU A 1 86  ? 89.088  136.796 117.957 1.00 52.06  ? 86  LEU A CD1 1 
ATOM 622  C CD2 . LEU A 1 86  ? 87.886  134.633 117.642 1.00 50.27  ? 86  LEU A CD2 1 
ATOM 623  N N   . LEU A 1 87  ? 88.640  134.748 112.713 1.00 57.10  ? 87  LEU A N   1 
ATOM 624  C CA  . LEU A 1 87  ? 87.736  134.573 111.579 1.00 51.63  ? 87  LEU A CA  1 
ATOM 625  C C   . LEU A 1 87  ? 87.695  133.125 111.106 1.00 59.73  ? 87  LEU A C   1 
ATOM 626  O O   . LEU A 1 87  ? 86.613  132.583 110.853 1.00 56.80  ? 87  LEU A O   1 
ATOM 627  C CB  . LEU A 1 87  ? 88.166  135.494 110.435 1.00 53.18  ? 87  LEU A CB  1 
ATOM 628  C CG  . LEU A 1 87  ? 87.513  135.373 109.054 1.00 55.80  ? 87  LEU A CG  1 
ATOM 629  C CD1 . LEU A 1 87  ? 87.358  136.744 108.452 1.00 56.63  ? 87  LEU A CD1 1 
ATOM 630  C CD2 . LEU A 1 87  ? 88.343  134.504 108.114 1.00 56.31  ? 87  LEU A CD2 1 
ATOM 631  N N   . HIS A 1 88  ? 88.864  132.493 110.958 1.00 65.04  ? 88  HIS A N   1 
ATOM 632  C CA  . HIS A 1 88  ? 88.908  131.103 110.509 1.00 57.84  ? 88  HIS A CA  1 
ATOM 633  C C   . HIS A 1 88  ? 88.259  130.168 111.522 1.00 53.96  ? 88  HIS A C   1 
ATOM 634  O O   . HIS A 1 88  ? 87.508  129.257 111.140 1.00 52.53  ? 88  HIS A O   1 
ATOM 635  C CB  . HIS A 1 88  ? 90.349  130.676 110.246 1.00 51.39  ? 88  HIS A CB  1 
ATOM 636  C CG  . HIS A 1 88  ? 90.508  129.205 110.030 1.00 52.74  ? 88  HIS A CG  1 
ATOM 637  N ND1 . HIS A 1 88  ? 90.871  128.340 111.040 1.00 56.11  ? 88  HIS A ND1 1 
ATOM 638  C CD2 . HIS A 1 88  ? 90.350  128.444 108.922 1.00 60.09  ? 88  HIS A CD2 1 
ATOM 639  C CE1 . HIS A 1 88  ? 90.932  127.110 110.563 1.00 57.87  ? 88  HIS A CE1 1 
ATOM 640  N NE2 . HIS A 1 88  ? 90.620  127.145 109.280 1.00 57.17  ? 88  HIS A NE2 1 
ATOM 641  N N   . LYS A 1 89  ? 88.529  130.385 112.815 1.00 53.89  ? 89  LYS A N   1 
ATOM 642  C CA  . LYS A 1 89  ? 87.897  129.569 113.848 1.00 51.92  ? 89  LYS A CA  1 
ATOM 643  C C   . LYS A 1 89  ? 86.384  129.748 113.848 1.00 50.77  ? 89  LYS A C   1 
ATOM 644  O O   . LYS A 1 89  ? 85.640  128.768 113.979 1.00 59.63  ? 89  LYS A O   1 
ATOM 645  C CB  . LYS A 1 89  ? 88.477  129.912 115.218 1.00 56.55  ? 89  LYS A CB  1 
ATOM 646  C CG  . LYS A 1 89  ? 89.867  129.349 115.458 1.00 65.87  ? 89  LYS A CG  1 
ATOM 647  C CD  . LYS A 1 89  ? 89.947  127.878 115.084 1.00 61.00  ? 89  LYS A CD  1 
ATOM 648  C CE  . LYS A 1 89  ? 91.389  127.427 114.922 1.00 57.46  ? 89  LYS A CE  1 
ATOM 649  N NZ  . LYS A 1 89  ? 92.111  128.239 113.904 1.00 57.51  ? 89  LYS A NZ  1 
ATOM 650  N N   . SER A 1 90  ? 85.914  130.990 113.673 1.00 64.37  ? 90  SER A N   1 
ATOM 651  C CA  . SER A 1 90  ? 84.480  131.261 113.620 1.00 65.84  ? 90  SER A CA  1 
ATOM 652  C C   . SER A 1 90  ? 83.824  130.604 112.413 1.00 64.84  ? 90  SER A C   1 
ATOM 653  O O   . SER A 1 90  ? 82.727  130.043 112.528 1.00 66.57  ? 90  SER A O   1 
ATOM 654  C CB  . SER A 1 90  ? 84.231  132.767 113.598 1.00 67.11  ? 90  SER A CB  1 
ATOM 655  O OG  . SER A 1 90  ? 82.863  133.045 113.357 1.00 61.75  ? 90  SER A OG  1 
ATOM 656  N N   . ARG A 1 91  ? 84.476  130.669 111.246 1.00 71.31  ? 91  ARG A N   1 
ATOM 657  C CA  . ARG A 1 91  ? 83.934  130.031 110.048 1.00 71.34  ? 91  ARG A CA  1 
ATOM 658  C C   . ARG A 1 91  ? 83.838  128.522 110.227 1.00 76.39  ? 91  ARG A C   1 
ATOM 659  O O   . ARG A 1 91  ? 82.840  127.903 109.833 1.00 72.70  ? 91  ARG A O   1 
ATOM 660  C CB  . ARG A 1 91  ? 84.799  130.364 108.830 1.00 69.64  ? 91  ARG A CB  1 
ATOM 661  C CG  . ARG A 1 91  ? 84.697  131.802 108.359 1.00 74.08  ? 91  ARG A CG  1 
ATOM 662  C CD  . ARG A 1 91  ? 83.289  132.161 107.929 1.00 74.46  ? 91  ARG A CD  1 
ATOM 663  N NE  . ARG A 1 91  ? 83.244  132.609 106.543 1.00 76.41  ? 91  ARG A NE  1 
ATOM 664  C CZ  . ARG A 1 91  ? 82.224  133.259 106.000 1.00 74.14  ? 91  ARG A CZ  1 
ATOM 665  N NH1 . ARG A 1 91  ? 81.143  133.557 106.701 1.00 72.18  ? 91  ARG A NH1 1 
ATOM 666  N NH2 . ARG A 1 91  ? 82.292  133.621 104.722 1.00 74.83  ? 91  ARG A NH2 1 
ATOM 667  N N   . TYR A 1 92  ? 84.856  127.918 110.849 1.00 81.04  ? 92  TYR A N   1 
ATOM 668  C CA  . TYR A 1 92  ? 84.835  126.475 111.070 1.00 71.94  ? 92  TYR A CA  1 
ATOM 669  C C   . TYR A 1 92  ? 83.740  126.064 112.054 1.00 70.72  ? 92  TYR A C   1 
ATOM 670  O O   . TYR A 1 92  ? 83.037  125.074 111.813 1.00 73.14  ? 92  TYR A O   1 
ATOM 671  C CB  . TYR A 1 92  ? 86.204  126.002 111.554 1.00 72.59  ? 92  TYR A CB  1 
ATOM 672  C CG  . TYR A 1 92  ? 86.618  124.650 111.019 1.00 71.29  ? 92  TYR A CG  1 
ATOM 673  C CD1 . TYR A 1 92  ? 87.150  124.521 109.741 1.00 70.75  ? 92  TYR A CD1 1 
ATOM 674  C CD2 . TYR A 1 92  ? 86.488  123.505 111.795 1.00 72.60  ? 92  TYR A CD2 1 
ATOM 675  C CE1 . TYR A 1 92  ? 87.537  123.289 109.251 1.00 70.49  ? 92  TYR A CE1 1 
ATOM 676  C CE2 . TYR A 1 92  ? 86.872  122.270 111.313 1.00 76.09  ? 92  TYR A CE2 1 
ATOM 677  C CZ  . TYR A 1 92  ? 87.395  122.167 110.041 1.00 73.11  ? 92  TYR A CZ  1 
ATOM 678  O OH  . TYR A 1 92  ? 87.775  120.935 109.561 1.00 73.96  ? 92  TYR A OH  1 
ATOM 679  N N   . VAL A 1 93  ? 83.567  126.800 113.162 1.00 73.90  ? 93  VAL A N   1 
ATOM 680  C CA  . VAL A 1 93  ? 82.550  126.374 114.127 1.00 74.42  ? 93  VAL A CA  1 
ATOM 681  C C   . VAL A 1 93  ? 81.156  126.632 113.558 1.00 74.66  ? 93  VAL A C   1 
ATOM 682  O O   . VAL A 1 93  ? 80.223  125.854 113.791 1.00 74.99  ? 93  VAL A O   1 
ATOM 683  C CB  . VAL A 1 93  ? 82.736  127.046 115.509 1.00 74.53  ? 93  VAL A CB  1 
ATOM 684  C CG1 . VAL A 1 93  ? 82.962  128.531 115.409 1.00 74.46  ? 93  VAL A CG1 1 
ATOM 685  C CG2 . VAL A 1 93  ? 81.600  126.713 116.480 1.00 74.91  ? 93  VAL A CG2 1 
ATOM 686  N N   . ALA A 1 94  ? 81.000  127.702 112.768 1.00 70.24  ? 94  ALA A N   1 
ATOM 687  C CA  . ALA A 1 94  ? 79.717  127.972 112.125 1.00 75.53  ? 94  ALA A CA  1 
ATOM 688  C C   . ALA A 1 94  ? 79.367  126.899 111.101 1.00 78.01  ? 94  ALA A C   1 
ATOM 689  O O   . ALA A 1 94  ? 78.204  126.493 110.994 1.00 79.32  ? 94  ALA A O   1 
ATOM 690  C CB  . ALA A 1 94  ? 79.739  129.352 111.470 1.00 76.10  ? 94  ALA A CB  1 
ATOM 691  N N   . SER A 1 95  ? 80.357  126.423 110.340 1.00 73.28  ? 95  SER A N   1 
ATOM 692  C CA  . SER A 1 95  ? 80.096  125.339 109.401 1.00 74.68  ? 95  SER A CA  1 
ATOM 693  C C   . SER A 1 95  ? 79.937  123.991 110.095 1.00 77.21  ? 95  SER A C   1 
ATOM 694  O O   . SER A 1 95  ? 79.382  123.065 109.494 1.00 73.27  ? 95  SER A O   1 
ATOM 695  C CB  . SER A 1 95  ? 81.217  125.256 108.364 1.00 74.60  ? 95  SER A CB  1 
ATOM 696  O OG  . SER A 1 95  ? 81.255  123.975 107.761 1.00 73.79  ? 95  SER A OG  1 
ATOM 697  N N   . ASN A 1 96  ? 80.404  123.858 111.339 1.00 81.61  ? 96  ASN A N   1 
ATOM 698  C CA  . ASN A 1 96  ? 80.366  122.569 112.024 1.00 77.79  ? 96  ASN A CA  1 
ATOM 699  C C   . ASN A 1 96  ? 79.661  122.641 113.376 1.00 75.41  ? 96  ASN A C   1 
ATOM 700  O O   . ASN A 1 96  ? 80.193  122.150 114.377 1.00 74.66  ? 96  ASN A O   1 
ATOM 701  C CB  . ASN A 1 96  ? 81.787  122.031 112.216 1.00 76.89  ? 96  ASN A CB  1 
ATOM 702  C CG  . ASN A 1 96  ? 82.327  121.343 110.976 1.00 74.07  ? 96  ASN A CG  1 
ATOM 703  O OD1 . ASN A 1 96  ? 81.800  121.508 109.877 1.00 72.04  ? 96  ASN A OD1 1 
ATOM 704  N ND2 . ASN A 1 96  ? 83.388  120.565 111.150 1.00 74.50  ? 96  ASN A ND2 1 
ATOM 705  N N   . ARG A 1 97  ? 78.475  123.244 113.425 1.00 79.08  ? 97  ARG A N   1 
ATOM 706  C CA  . ARG A 1 97  ? 77.686  123.329 114.651 1.00 79.09  ? 97  ARG A CA  1 
ATOM 707  C C   . ARG A 1 97  ? 76.347  122.617 114.493 1.00 83.11  ? 97  ARG A C   1 
ATOM 708  O O   . ARG A 1 97  ? 75.334  123.020 115.068 1.00 83.46  ? 97  ARG A O   1 
ATOM 709  C CB  . ARG A 1 97  ? 77.471  124.783 115.069 1.00 82.50  ? 97  ARG A CB  1 
ATOM 710  C CG  . ARG A 1 97  ? 77.395  124.998 116.579 1.00 83.49  ? 97  ARG A CG  1 
ATOM 711  C CD  . ARG A 1 97  ? 77.174  126.463 116.929 1.00 82.81  ? 97  ARG A CD  1 
ATOM 712  N NE  . ARG A 1 97  ? 78.310  127.298 116.559 1.00 81.83  ? 97  ARG A NE  1 
ATOM 713  C CZ  . ARG A 1 97  ? 78.288  128.213 115.600 1.00 82.66  ? 97  ARG A CZ  1 
ATOM 714  N NH1 . ARG A 1 97  ? 77.202  128.430 114.877 1.00 83.03  ? 97  ARG A NH1 1 
ATOM 715  N NH2 . ARG A 1 97  ? 79.383  128.928 115.361 1.00 82.43  ? 97  ARG A NH2 1 
ATOM 716  N N   . ARG A 1 98  ? 76.324  121.544 113.702 1.00 95.78  ? 98  ARG A N   1 
ATOM 717  C CA  . ARG A 1 98  ? 75.091  120.781 113.540 1.00 96.44  ? 98  ARG A CA  1 
ATOM 718  C C   . ARG A 1 98  ? 74.804  119.919 114.763 1.00 100.31 ? 98  ARG A C   1 
ATOM 719  O O   . ARG A 1 98  ? 73.638  119.691 115.105 1.00 99.65  ? 98  ARG A O   1 
ATOM 720  C CB  . ARG A 1 98  ? 75.167  119.919 112.279 1.00 95.44  ? 98  ARG A CB  1 
ATOM 721  C CG  . ARG A 1 98  ? 75.190  120.722 110.989 1.00 93.87  ? 98  ARG A CG  1 
ATOM 722  C CD  . ARG A 1 98  ? 73.791  121.164 110.593 1.00 95.09  ? 98  ARG A CD  1 
ATOM 723  N NE  . ARG A 1 98  ? 73.798  122.448 109.902 1.00 100.24 ? 98  ARG A NE  1 
ATOM 724  C CZ  . ARG A 1 98  ? 72.887  123.396 110.074 1.00 100.48 ? 98  ARG A CZ  1 
ATOM 725  N NH1 . ARG A 1 98  ? 71.876  123.240 110.913 1.00 100.82 ? 98  ARG A NH1 1 
ATOM 726  N NH2 . ARG A 1 98  ? 72.992  124.530 109.385 1.00 96.82  ? 98  ARG A NH2 1 
ATOM 727  N N   . SER A 1 99  ? 75.847  119.439 115.430 1.00 104.65 ? 99  SER A N   1 
ATOM 728  C CA  . SER A 1 99  ? 75.724  118.641 116.639 1.00 105.29 ? 99  SER A CA  1 
ATOM 729  C C   . SER A 1 99  ? 76.495  119.308 117.772 1.00 104.80 ? 99  SER A C   1 
ATOM 730  O O   . SER A 1 99  ? 77.248  120.264 117.567 1.00 99.33  ? 99  SER A O   1 
ATOM 731  C CB  . SER A 1 99  ? 76.232  117.211 116.412 1.00 99.21  ? 99  SER A CB  1 
ATOM 732  O OG  . SER A 1 99  ? 76.257  116.479 117.625 1.00 99.84  ? 99  SER A OG  1 
ATOM 733  N N   . ILE A 1 100 ? 76.296  118.791 118.983 1.00 100.07 ? 100 ILE A N   1 
ATOM 734  C CA  . ILE A 1 100 ? 76.952  119.312 120.180 1.00 94.09  ? 100 ILE A CA  1 
ATOM 735  C C   . ILE A 1 100 ? 77.953  118.222 120.568 1.00 94.42  ? 100 ILE A C   1 
ATOM 736  O O   . ILE A 1 100 ? 78.213  117.962 121.750 1.00 95.36  ? 100 ILE A O   1 
ATOM 737  C CB  . ILE A 1 100 ? 75.938  119.648 121.301 1.00 94.34  ? 100 ILE A CB  1 
ATOM 738  C CG1 . ILE A 1 100 ? 74.827  120.601 120.835 1.00 92.50  ? 100 ILE A CG1 1 
ATOM 739  C CG2 . ILE A 1 100 ? 76.580  120.487 122.411 1.00 94.39  ? 100 ILE A CG2 1 
ATOM 740  C CD1 . ILE A 1 100 ? 75.238  121.723 119.879 1.00 91.55  ? 100 ILE A CD1 1 
ATOM 741  N N   . PHE A 1 101 ? 78.477  117.528 119.553 1.00 94.12  ? 101 PHE A N   1 
ATOM 742  C CA  . PHE A 1 101 ? 79.476  116.489 119.789 1.00 93.49  ? 101 PHE A CA  1 
ATOM 743  C C   . PHE A 1 101 ? 80.759  117.072 120.369 1.00 95.07  ? 101 PHE A C   1 
ATOM 744  O O   . PHE A 1 101 ? 81.349  116.496 121.291 1.00 96.94  ? 101 PHE A O   1 
ATOM 745  C CB  . PHE A 1 101 ? 79.766  115.738 118.489 1.00 91.36  ? 101 PHE A CB  1 
ATOM 746  C CG  . PHE A 1 101 ? 80.931  114.794 118.581 1.00 93.23  ? 101 PHE A CG  1 
ATOM 747  C CD1 . PHE A 1 101 ? 80.826  113.613 119.300 1.00 92.41  ? 101 PHE A CD1 1 
ATOM 748  C CD2 . PHE A 1 101 ? 82.130  115.084 117.947 1.00 93.22  ? 101 PHE A CD2 1 
ATOM 749  C CE1 . PHE A 1 101 ? 81.895  112.740 119.388 1.00 98.48  ? 101 PHE A CE1 1 
ATOM 750  C CE2 . PHE A 1 101 ? 83.204  114.215 118.032 1.00 90.50  ? 101 PHE A CE2 1 
ATOM 751  C CZ  . PHE A 1 101 ? 83.086  113.042 118.753 1.00 94.12  ? 101 PHE A CZ  1 
ATOM 752  N N   . PHE A 1 102 ? 81.210  118.208 119.840 1.00 89.07  ? 102 PHE A N   1 
ATOM 753  C CA  . PHE A 1 102 ? 82.380  118.878 120.389 1.00 87.24  ? 102 PHE A CA  1 
ATOM 754  C C   . PHE A 1 102 ? 82.060  119.444 121.766 1.00 89.91  ? 102 PHE A C   1 
ATOM 755  O O   . PHE A 1 102 ? 80.965  119.961 122.004 1.00 94.32  ? 102 PHE A O   1 
ATOM 756  C CB  . PHE A 1 102 ? 82.860  119.992 119.450 1.00 85.03  ? 102 PHE A CB  1 
ATOM 757  C CG  . PHE A 1 102 ? 81.897  121.146 119.315 1.00 89.05  ? 102 PHE A CG  1 
ATOM 758  C CD1 . PHE A 1 102 ? 80.817  121.071 118.449 1.00 92.55  ? 102 PHE A CD1 1 
ATOM 759  C CD2 . PHE A 1 102 ? 82.086  122.314 120.038 1.00 87.65  ? 102 PHE A CD2 1 
ATOM 760  C CE1 . PHE A 1 102 ? 79.936  122.129 118.322 1.00 88.61  ? 102 PHE A CE1 1 
ATOM 761  C CE2 . PHE A 1 102 ? 81.207  123.373 119.914 1.00 88.24  ? 102 PHE A CE2 1 
ATOM 762  C CZ  . PHE A 1 102 ? 80.133  123.279 119.054 1.00 87.24  ? 102 PHE A CZ  1 
ATOM 763  N N   . ARG A 1 103 ? 83.015  119.326 122.684 1.00 87.75  ? 103 ARG A N   1 
ATOM 764  C CA  . ARG A 1 103 ? 82.813  119.854 124.025 1.00 88.21  ? 103 ARG A CA  1 
ATOM 765  C C   . ARG A 1 103 ? 82.899  121.374 124.007 1.00 87.48  ? 103 ARG A C   1 
ATOM 766  O O   . ARG A 1 103 ? 83.811  121.950 123.407 1.00 85.00  ? 103 ARG A O   1 
ATOM 767  C CB  . ARG A 1 103 ? 83.836  119.270 124.997 1.00 86.38  ? 103 ARG A CB  1 
ATOM 768  C CG  . ARG A 1 103 ? 83.210  118.375 126.054 1.00 85.96  ? 103 ARG A CG  1 
ATOM 769  C CD  . ARG A 1 103 ? 84.194  118.014 127.151 1.00 86.73  ? 103 ARG A CD  1 
ATOM 770  N NE  . ARG A 1 103 ? 83.567  117.194 128.181 1.00 93.16  ? 103 ARG A NE  1 
ATOM 771  C CZ  . ARG A 1 103 ? 84.136  116.872 129.335 1.00 90.49  ? 103 ARG A CZ  1 
ATOM 772  N NH1 . ARG A 1 103 ? 85.355  117.284 129.643 1.00 86.90  ? 103 ARG A NH1 1 
ATOM 773  N NH2 . ARG A 1 103 ? 83.465  116.118 130.201 1.00 89.70  ? 103 ARG A NH2 1 
ATOM 774  N N   . THR A 1 104 ? 81.937  122.021 124.667 1.00 75.86  ? 104 THR A N   1 
ATOM 775  C CA  . THR A 1 104 ? 81.889  123.475 124.701 1.00 73.92  ? 104 THR A CA  1 
ATOM 776  C C   . THR A 1 104 ? 83.044  124.074 125.492 1.00 72.37  ? 104 THR A C   1 
ATOM 777  O O   . THR A 1 104 ? 83.402  125.231 125.255 1.00 73.73  ? 104 THR A O   1 
ATOM 778  C CB  . THR A 1 104 ? 80.553  123.934 125.291 1.00 76.46  ? 104 THR A CB  1 
ATOM 779  O OG1 . THR A 1 104 ? 79.516  123.037 124.874 1.00 72.65  ? 104 THR A OG1 1 
ATOM 780  C CG2 . THR A 1 104 ? 80.202  125.340 124.824 1.00 77.05  ? 104 THR A CG2 1 
ATOM 781  N N   . SER A 1 105 ? 83.643  123.308 126.410 1.00 60.80  ? 105 SER A N   1 
ATOM 782  C CA  . SER A 1 105 ? 84.709  123.839 127.257 1.00 66.89  ? 105 SER A CA  1 
ATOM 783  C C   . SER A 1 105 ? 85.966  124.165 126.455 1.00 75.12  ? 105 SER A C   1 
ATOM 784  O O   . SER A 1 105 ? 86.612  125.193 126.697 1.00 75.40  ? 105 SER A O   1 
ATOM 785  C CB  . SER A 1 105 ? 85.028  122.844 128.372 1.00 65.03  ? 105 SER A CB  1 
ATOM 786  O OG  . SER A 1 105 ? 85.259  121.551 127.843 1.00 68.44  ? 105 SER A OG  1 
ATOM 787  N N   . HIS A 1 106 ? 86.324  123.304 125.497 1.00 69.82  ? 106 HIS A N   1 
ATOM 788  C CA  . HIS A 1 106 ? 87.551  123.499 124.725 1.00 67.69  ? 106 HIS A CA  1 
ATOM 789  C C   . HIS A 1 106 ? 87.478  124.757 123.865 1.00 67.12  ? 106 HIS A C   1 
ATOM 790  O O   . HIS A 1 106 ? 88.360  125.625 123.936 1.00 65.74  ? 106 HIS A O   1 
ATOM 791  C CB  . HIS A 1 106 ? 87.810  122.263 123.864 1.00 66.12  ? 106 HIS A CB  1 
ATOM 792  C CG  . HIS A 1 106 ? 88.899  122.441 122.852 1.00 64.84  ? 106 HIS A CG  1 
ATOM 793  N ND1 . HIS A 1 106 ? 90.230  122.252 123.152 1.00 66.72  ? 106 HIS A ND1 1 
ATOM 794  C CD2 . HIS A 1 106 ? 88.851  122.771 121.540 1.00 66.21  ? 106 HIS A CD2 1 
ATOM 795  C CE1 . HIS A 1 106 ? 90.957  122.468 122.070 1.00 68.76  ? 106 HIS A CE1 1 
ATOM 796  N NE2 . HIS A 1 106 ? 90.145  122.784 121.078 1.00 69.62  ? 106 HIS A NE2 1 
ATOM 797  N N   . ASN A 1 107 ? 86.417  124.886 123.062 1.00 65.93  ? 107 ASN A N   1 
ATOM 798  C CA  . ASN A 1 107 ? 86.263  126.080 122.237 1.00 65.91  ? 107 ASN A CA  1 
ATOM 799  C C   . ASN A 1 107 ? 85.951  127.308 123.081 1.00 63.54  ? 107 ASN A C   1 
ATOM 800  O O   . ASN A 1 107 ? 86.298  128.427 122.687 1.00 62.07  ? 107 ASN A O   1 
ATOM 801  C CB  . ASN A 1 107 ? 85.180  125.861 121.184 1.00 61.25  ? 107 ASN A CB  1 
ATOM 802  C CG  . ASN A 1 107 ? 85.686  125.079 119.991 1.00 61.48  ? 107 ASN A CG  1 
ATOM 803  O OD1 . ASN A 1 107 ? 86.821  125.259 119.554 1.00 63.41  ? 107 ASN A OD1 1 
ATOM 804  N ND2 . ASN A 1 107 ? 84.844  124.204 119.458 1.00 64.16  ? 107 ASN A ND2 1 
ATOM 805  N N   . LEU A 1 108 ? 85.329  127.116 124.248 1.00 56.08  ? 108 LEU A N   1 
ATOM 806  C CA  . LEU A 1 108 ? 85.127  128.210 125.192 1.00 56.27  ? 108 LEU A CA  1 
ATOM 807  C C   . LEU A 1 108 ? 86.459  128.790 125.647 1.00 59.49  ? 108 LEU A C   1 
ATOM 808  O O   . LEU A 1 108 ? 86.663  130.008 125.608 1.00 64.16  ? 108 LEU A O   1 
ATOM 809  C CB  . LEU A 1 108 ? 84.312  127.711 126.389 1.00 54.74  ? 108 LEU A CB  1 
ATOM 810  C CG  . LEU A 1 108 ? 84.123  128.565 127.647 1.00 59.17  ? 108 LEU A CG  1 
ATOM 811  C CD1 . LEU A 1 108 ? 82.722  128.363 128.171 1.00 58.53  ? 108 LEU A CD1 1 
ATOM 812  C CD2 . LEU A 1 108 ? 85.122  128.201 128.739 1.00 64.56  ? 108 LEU A CD2 1 
ATOM 813  N N   . ALA A 1 109 ? 87.386  127.924 126.064 1.00 52.16  ? 109 ALA A N   1 
ATOM 814  C CA  . ALA A 1 109 ? 88.689  128.396 126.523 1.00 58.97  ? 109 ALA A CA  1 
ATOM 815  C C   . ALA A 1 109 ? 89.508  128.978 125.375 1.00 63.80  ? 109 ALA A C   1 
ATOM 816  O O   . ALA A 1 109 ? 90.219  129.977 125.559 1.00 66.34  ? 109 ALA A O   1 
ATOM 817  C CB  . ALA A 1 109 ? 89.441  127.259 127.213 1.00 62.17  ? 109 ALA A CB  1 
ATOM 818  N N   . GLU A 1 110 ? 89.400  128.385 124.180 1.00 57.88  ? 110 GLU A N   1 
ATOM 819  C CA  . GLU A 1 110 ? 90.106  128.912 123.012 1.00 54.11  ? 110 GLU A CA  1 
ATOM 820  C C   . GLU A 1 110 ? 89.631  130.319 122.658 1.00 53.69  ? 110 GLU A C   1 
ATOM 821  O O   . GLU A 1 110 ? 90.441  131.239 122.468 1.00 51.70  ? 110 GLU A O   1 
ATOM 822  C CB  . GLU A 1 110 ? 89.917  127.969 121.824 1.00 53.70  ? 110 GLU A CB  1 
ATOM 823  C CG  . GLU A 1 110 ? 90.148  128.612 120.468 1.00 50.13  ? 110 GLU A CG  1 
ATOM 824  C CD  . GLU A 1 110 ? 91.592  128.546 120.031 1.00 52.78  ? 110 GLU A CD  1 
ATOM 825  O OE1 . GLU A 1 110 ? 92.416  127.984 120.779 1.00 50.63  ? 110 GLU A OE1 1 
ATOM 826  O OE2 . GLU A 1 110 ? 91.905  129.058 118.938 1.00 51.95  ? 110 GLU A OE2 1 
ATOM 827  N N   . LEU A 1 111 ? 88.314  130.516 122.595 1.00 41.23  ? 111 LEU A N   1 
ATOM 828  C CA  . LEU A 1 111 ? 87.802  131.826 122.226 1.00 46.33  ? 111 LEU A CA  1 
ATOM 829  C C   . LEU A 1 111 ? 87.950  132.827 123.367 1.00 50.92  ? 111 LEU A C   1 
ATOM 830  O O   . LEU A 1 111 ? 88.046  134.031 123.113 1.00 47.21  ? 111 LEU A O   1 
ATOM 831  C CB  . LEU A 1 111 ? 86.349  131.709 121.768 1.00 47.15  ? 111 LEU A CB  1 
ATOM 832  C CG  . LEU A 1 111 ? 86.076  131.003 120.428 1.00 46.89  ? 111 LEU A CG  1 
ATOM 833  C CD1 . LEU A 1 111 ? 84.831  131.568 119.761 1.00 45.28  ? 111 LEU A CD1 1 
ATOM 834  C CD2 . LEU A 1 111 ? 87.263  131.073 119.471 1.00 46.16  ? 111 LEU A CD2 1 
ATOM 835  N N   . GLU A 1 112 ? 88.020  132.358 124.617 1.00 41.50  ? 112 GLU A N   1 
ATOM 836  C CA  . GLU A 1 112 ? 88.328  133.254 125.729 1.00 44.25  ? 112 GLU A CA  1 
ATOM 837  C C   . GLU A 1 112 ? 89.761  133.770 125.637 1.00 46.06  ? 112 GLU A C   1 
ATOM 838  O O   . GLU A 1 112 ? 90.018  134.969 125.834 1.00 49.68  ? 112 GLU A O   1 
ATOM 839  C CB  . GLU A 1 112 ? 88.095  132.530 127.056 1.00 42.02  ? 112 GLU A CB  1 
ATOM 840  C CG  . GLU A 1 112 ? 88.759  133.178 128.260 1.00 46.58  ? 112 GLU A CG  1 
ATOM 841  C CD  . GLU A 1 112 ? 90.023  132.458 128.694 1.00 52.96  ? 112 GLU A CD  1 
ATOM 842  O OE1 . GLU A 1 112 ? 90.386  131.452 128.052 1.00 51.90  ? 112 GLU A OE1 1 
ATOM 843  O OE2 . GLU A 1 112 ? 90.652  132.898 129.679 1.00 57.12  ? 112 GLU A OE2 1 
ATOM 844  N N   . ALA A 1 113 ? 90.708  132.877 125.324 1.00 44.05  ? 113 ALA A N   1 
ATOM 845  C CA  . ALA A 1 113 ? 92.094  133.299 125.135 1.00 48.36  ? 113 ALA A CA  1 
ATOM 846  C C   . ALA A 1 113 ? 92.227  134.250 123.953 1.00 39.10  ? 113 ALA A C   1 
ATOM 847  O O   . ALA A 1 113 ? 93.000  135.213 124.005 1.00 42.72  ? 113 ALA A O   1 
ATOM 848  C CB  . ALA A 1 113 ? 92.996  132.081 124.948 1.00 41.88  ? 113 ALA A CB  1 
ATOM 849  N N   . TYR A 1 114 ? 91.464  134.015 122.886 1.00 33.44  ? 114 TYR A N   1 
ATOM 850  C CA  . TYR A 1 114 ? 91.536  134.932 121.754 1.00 31.49  ? 114 TYR A CA  1 
ATOM 851  C C   . TYR A 1 114 ? 90.844  136.266 122.032 1.00 33.89  ? 114 TYR A C   1 
ATOM 852  O O   . TYR A 1 114 ? 91.262  137.295 121.486 1.00 39.58  ? 114 TYR A O   1 
ATOM 853  C CB  . TYR A 1 114 ? 90.968  134.266 120.509 1.00 32.47  ? 114 TYR A CB  1 
ATOM 854  C CG  . TYR A 1 114 ? 92.042  133.574 119.708 1.00 36.91  ? 114 TYR A CG  1 
ATOM 855  C CD1 . TYR A 1 114 ? 92.950  132.718 120.320 1.00 32.23  ? 114 TYR A CD1 1 
ATOM 856  C CD2 . TYR A 1 114 ? 92.162  133.786 118.345 1.00 41.91  ? 114 TYR A CD2 1 
ATOM 857  C CE1 . TYR A 1 114 ? 93.937  132.089 119.591 1.00 35.76  ? 114 TYR A CE1 1 
ATOM 858  C CE2 . TYR A 1 114 ? 93.143  133.163 117.613 1.00 42.53  ? 114 TYR A CE2 1 
ATOM 859  C CZ  . TYR A 1 114 ? 94.029  132.316 118.236 1.00 39.90  ? 114 TYR A CZ  1 
ATOM 860  O OH  . TYR A 1 114 ? 95.007  131.697 117.495 1.00 38.05  ? 114 TYR A OH  1 
ATOM 861  N N   . LEU A 1 115 ? 89.813  136.278 122.883 1.00 39.40  ? 115 LEU A N   1 
ATOM 862  C CA  . LEU A 1 115 ? 89.268  137.541 123.377 1.00 41.41  ? 115 LEU A CA  1 
ATOM 863  C C   . LEU A 1 115 ? 90.314  138.324 124.156 1.00 44.45  ? 115 LEU A C   1 
ATOM 864  O O   . LEU A 1 115 ? 90.439  139.548 123.994 1.00 40.63  ? 115 LEU A O   1 
ATOM 865  C CB  . LEU A 1 115 ? 88.051  137.281 124.263 1.00 31.19  ? 115 LEU A CB  1 
ATOM 866  C CG  . LEU A 1 115 ? 86.981  138.371 124.267 1.00 30.31  ? 115 LEU A CG  1 
ATOM 867  C CD1 . LEU A 1 115 ? 86.173  138.296 123.004 1.00 37.99  ? 115 LEU A CD1 1 
ATOM 868  C CD2 . LEU A 1 115 ? 86.087  138.260 125.491 1.00 40.98  ? 115 LEU A CD2 1 
ATOM 869  N N   . ALA A 1 116 ? 91.069  137.630 125.012 1.00 38.15  ? 116 ALA A N   1 
ATOM 870  C CA  . ALA A 1 116 ? 92.144  138.286 125.751 1.00 40.94  ? 116 ALA A CA  1 
ATOM 871  C C   . ALA A 1 116 ? 93.213  138.826 124.807 1.00 47.85  ? 116 ALA A C   1 
ATOM 872  O O   . ALA A 1 116 ? 93.736  139.930 125.013 1.00 37.70  ? 116 ALA A O   1 
ATOM 873  C CB  . ALA A 1 116 ? 92.754  137.314 126.760 1.00 43.75  ? 116 ALA A CB  1 
ATOM 874  N N   . ALA A 1 117 ? 93.535  138.067 123.756 1.00 52.19  ? 117 ALA A N   1 
ATOM 875  C CA  . ALA A 1 117 ? 94.517  138.523 122.777 1.00 34.15  ? 117 ALA A CA  1 
ATOM 876  C C   . ALA A 1 117 ? 94.049  139.778 122.055 1.00 30.78  ? 117 ALA A C   1 
ATOM 877  O O   . ALA A 1 117 ? 94.822  140.730 121.888 1.00 40.83  ? 117 ALA A O   1 
ATOM 878  C CB  . ALA A 1 117 ? 94.824  137.412 121.776 1.00 34.00  ? 117 ALA A CB  1 
ATOM 879  N N   . LEU A 1 118 ? 92.781  139.808 121.640 1.00 24.77  ? 118 LEU A N   1 
ATOM 880  C CA  . LEU A 1 118 ? 92.284  140.976 120.922 1.00 28.48  ? 118 LEU A CA  1 
ATOM 881  C C   . LEU A 1 118 ? 92.207  142.200 121.826 1.00 33.49  ? 118 LEU A C   1 
ATOM 882  O O   . LEU A 1 118 ? 92.541  143.308 121.393 1.00 41.14  ? 118 LEU A O   1 
ATOM 883  C CB  . LEU A 1 118 ? 90.926  140.681 120.291 1.00 49.54  ? 118 LEU A CB  1 
ATOM 884  C CG  . LEU A 1 118 ? 90.781  141.187 118.852 1.00 46.60  ? 118 LEU A CG  1 
ATOM 885  C CD1 . LEU A 1 118 ? 91.960  140.750 117.999 1.00 36.36  ? 118 LEU A CD1 1 
ATOM 886  C CD2 . LEU A 1 118 ? 89.477  140.709 118.243 1.00 42.10  ? 118 LEU A CD2 1 
ATOM 887  N N   . THR A 1 119 ? 91.804  142.032 123.092 1.00 40.61  ? 119 THR A N   1 
ATOM 888  C CA  . THR A 1 119 ? 91.741  143.209 123.960 1.00 54.23  ? 119 THR A CA  1 
ATOM 889  C C   . THR A 1 119 ? 93.139  143.712 124.340 1.00 54.84  ? 119 THR A C   1 
ATOM 890  O O   . THR A 1 119 ? 93.350  144.933 124.440 1.00 50.79  ? 119 THR A O   1 
ATOM 891  C CB  . THR A 1 119 ? 90.863  142.930 125.195 1.00 46.20  ? 119 THR A CB  1 
ATOM 892  O OG1 . THR A 1 119 ? 90.593  144.157 125.885 1.00 50.85  ? 119 THR A OG1 1 
ATOM 893  C CG2 . THR A 1 119 ? 91.493  141.948 126.163 1.00 45.29  ? 119 THR A CG2 1 
ATOM 894  N N   . GLN A 1 120 ? 94.122  142.810 124.479 1.00 49.82  ? 120 GLN A N   1 
ATOM 895  C CA  . GLN A 1 120 ? 95.481  143.256 124.778 1.00 44.60  ? 120 GLN A CA  1 
ATOM 896  C C   . GLN A 1 120 ? 96.107  143.959 123.581 1.00 36.68  ? 120 GLN A C   1 
ATOM 897  O O   . GLN A 1 120 ? 96.796  144.976 123.739 1.00 37.89  ? 120 GLN A O   1 
ATOM 898  C CB  . GLN A 1 120 ? 96.339  142.070 125.218 1.00 52.88  ? 120 GLN A CB  1 
ATOM 899  C CG  . GLN A 1 120 ? 96.062  141.598 126.636 1.00 54.79  ? 120 GLN A CG  1 
ATOM 900  C CD  . GLN A 1 120 ? 96.054  142.718 127.654 1.00 54.42  ? 120 GLN A CD  1 
ATOM 901  O OE1 . GLN A 1 120 ? 95.166  142.787 128.500 1.00 51.66  ? 120 GLN A OE1 1 
ATOM 902  N NE2 . GLN A 1 120 ? 97.081  143.560 127.625 1.00 53.00  ? 120 GLN A NE2 1 
ATOM 903  N N   . LEU A 1 121 ? 95.866  143.445 122.373 1.00 37.84  ? 121 LEU A N   1 
ATOM 904  C CA  . LEU A 1 121 ? 96.341  144.144 121.189 1.00 27.45  ? 121 LEU A CA  1 
ATOM 905  C C   . LEU A 1 121 ? 95.614  145.467 120.993 1.00 39.89  ? 121 LEU A C   1 
ATOM 906  O O   . LEU A 1 121 ? 96.198  146.407 120.450 1.00 40.47  ? 121 LEU A O   1 
ATOM 907  C CB  . LEU A 1 121 ? 96.188  143.264 119.954 1.00 29.57  ? 121 LEU A CB  1 
ATOM 908  C CG  . LEU A 1 121 ? 97.210  142.135 119.839 1.00 29.24  ? 121 LEU A CG  1 
ATOM 909  C CD1 . LEU A 1 121 ? 97.091  141.459 118.494 1.00 37.12  ? 121 LEU A CD1 1 
ATOM 910  C CD2 . LEU A 1 121 ? 98.613  142.650 120.057 1.00 40.07  ? 121 LEU A CD2 1 
ATOM 911  N N   . ARG A 1 122 ? 94.357  145.567 121.439 1.00 48.94  ? 122 ARG A N   1 
ATOM 912  C CA  . ARG A 1 122 ? 93.664  146.854 121.415 1.00 51.82  ? 122 ARG A CA  1 
ATOM 913  C C   . ARG A 1 122 ? 94.358  147.869 122.313 1.00 54.30  ? 122 ARG A C   1 
ATOM 914  O O   . ARG A 1 122 ? 94.577  149.022 121.911 1.00 47.44  ? 122 ARG A O   1 
ATOM 915  C CB  . ARG A 1 122 ? 92.204  146.673 121.835 1.00 40.46  ? 122 ARG A CB  1 
ATOM 916  C CG  . ARG A 1 122 ? 91.539  147.947 122.337 1.00 42.73  ? 122 ARG A CG  1 
ATOM 917  C CD  . ARG A 1 122 ? 90.028  147.865 122.261 1.00 49.53  ? 122 ARG A CD  1 
ATOM 918  N NE  . ARG A 1 122 ? 89.388  148.910 123.050 1.00 53.84  ? 122 ARG A NE  1 
ATOM 919  C CZ  . ARG A 1 122 ? 88.092  148.954 123.324 1.00 49.29  ? 122 ARG A CZ  1 
ATOM 920  N NH1 . ARG A 1 122 ? 87.263  148.020 122.890 1.00 41.33  ? 122 ARG A NH1 1 
ATOM 921  N NH2 . ARG A 1 122 ? 87.616  149.961 124.050 1.00 52.50  ? 122 ARG A NH2 1 
ATOM 922  N N   . ALA A 1 123 ? 94.733  147.447 123.525 1.00 48.68  ? 123 ALA A N   1 
ATOM 923  C CA  . ALA A 1 123 ? 95.456  148.340 124.430 1.00 47.86  ? 123 ALA A CA  1 
ATOM 924  C C   . ALA A 1 123 ? 96.809  148.753 123.852 1.00 47.28  ? 123 ALA A C   1 
ATOM 925  O O   . ALA A 1 123 ? 97.200  149.927 123.933 1.00 47.78  ? 123 ALA A O   1 
ATOM 926  C CB  . ALA A 1 123 ? 95.632  147.672 125.791 1.00 46.71  ? 123 ALA A CB  1 
ATOM 927  N N   . LEU A 1 124 ? 97.526  147.806 123.236 1.00 47.08  ? 124 LEU A N   1 
ATOM 928  C CA  . LEU A 1 124 ? 98.833  148.126 122.659 1.00 36.11  ? 124 LEU A CA  1 
ATOM 929  C C   . LEU A 1 124 ? 98.711  149.050 121.449 1.00 39.32  ? 124 LEU A C   1 
ATOM 930  O O   . LEU A 1 124 ? 99.555  149.930 121.252 1.00 41.91  ? 124 LEU A O   1 
ATOM 931  C CB  . LEU A 1 124 ? 99.573  146.845 122.278 1.00 41.04  ? 124 LEU A CB  1 
ATOM 932  C CG  . LEU A 1 124 ? 100.346 146.135 123.391 1.00 28.15  ? 124 LEU A CG  1 
ATOM 933  C CD1 . LEU A 1 124 ? 101.278 145.091 122.803 1.00 32.57  ? 124 LEU A CD1 1 
ATOM 934  C CD2 . LEU A 1 124 ? 101.115 147.128 124.242 1.00 37.59  ? 124 LEU A CD2 1 
ATOM 935  N N   . VAL A 1 125 ? 97.674  148.867 120.628 1.00 37.32  ? 125 VAL A N   1 
ATOM 936  C CA  . VAL A 1 125 ? 97.476  149.732 119.469 1.00 35.79  ? 125 VAL A CA  1 
ATOM 937  C C   . VAL A 1 125 ? 97.103  151.144 119.913 1.00 40.02  ? 125 VAL A C   1 
ATOM 938  O O   . VAL A 1 125 ? 97.563  152.137 119.330 1.00 43.53  ? 125 VAL A O   1 
ATOM 939  C CB  . VAL A 1 125 ? 96.424  149.109 118.531 1.00 33.14  ? 125 VAL A CB  1 
ATOM 940  C CG1 . VAL A 1 125 ? 95.853  150.132 117.577 1.00 43.30  ? 125 VAL A CG1 1 
ATOM 941  C CG2 . VAL A 1 125 ? 97.043  147.972 117.741 1.00 42.10  ? 125 VAL A CG2 1 
ATOM 942  N N   . TYR A 1 126 ? 96.303  151.258 120.978 1.00 42.17  ? 126 TYR A N   1 
ATOM 943  C CA  . TYR A 1 126 ? 96.013  152.574 121.545 1.00 42.40  ? 126 TYR A CA  1 
ATOM 944  C C   . TYR A 1 126 ? 97.277  153.245 122.078 1.00 50.13  ? 126 TYR A C   1 
ATOM 945  O O   . TYR A 1 126 ? 97.460  154.459 121.919 1.00 57.66  ? 126 TYR A O   1 
ATOM 946  C CB  . TYR A 1 126 ? 94.967  152.451 122.653 1.00 45.28  ? 126 TYR A CB  1 
ATOM 947  C CG  . TYR A 1 126 ? 93.537  152.399 122.162 1.00 61.12  ? 126 TYR A CG  1 
ATOM 948  C CD1 . TYR A 1 126 ? 93.241  152.470 120.806 1.00 62.27  ? 126 TYR A CD1 1 
ATOM 949  C CD2 . TYR A 1 126 ? 92.483  152.279 123.058 1.00 58.43  ? 126 TYR A CD2 1 
ATOM 950  C CE1 . TYR A 1 126 ? 91.936  152.422 120.357 1.00 53.45  ? 126 TYR A CE1 1 
ATOM 951  C CE2 . TYR A 1 126 ? 91.175  152.230 122.618 1.00 50.97  ? 126 TYR A CE2 1 
ATOM 952  C CZ  . TYR A 1 126 ? 90.908  152.302 121.268 1.00 50.58  ? 126 TYR A CZ  1 
ATOM 953  O OH  . TYR A 1 126 ? 89.606  152.255 120.828 1.00 59.05  ? 126 TYR A OH  1 
ATOM 954  N N   . TYR A 1 127 ? 98.166  152.468 122.707 1.00 50.06  ? 127 TYR A N   1 
ATOM 955  C CA  . TYR A 1 127 ? 99.415  153.039 123.215 1.00 45.47  ? 127 TYR A CA  1 
ATOM 956  C C   . TYR A 1 127 ? 100.346 153.472 122.083 1.00 42.07  ? 127 TYR A C   1 
ATOM 957  O O   . TYR A 1 127 ? 101.031 154.499 122.191 1.00 43.06  ? 127 TYR A O   1 
ATOM 958  C CB  . TYR A 1 127 ? 100.102 152.036 124.136 1.00 50.53  ? 127 TYR A CB  1 
ATOM 959  C CG  . TYR A 1 127 ? 99.809  152.297 125.589 1.00 46.51  ? 127 TYR A CG  1 
ATOM 960  C CD1 . TYR A 1 127 ? 98.614  152.887 125.975 1.00 50.75  ? 127 TYR A CD1 1 
ATOM 961  C CD2 . TYR A 1 127 ? 100.716 151.950 126.576 1.00 46.91  ? 127 TYR A CD2 1 
ATOM 962  C CE1 . TYR A 1 127 ? 98.337  153.134 127.300 1.00 56.03  ? 127 TYR A CE1 1 
ATOM 963  C CE2 . TYR A 1 127 ? 100.443 152.188 127.903 1.00 46.05  ? 127 TYR A CE2 1 
ATOM 964  C CZ  . TYR A 1 127 ? 99.254  152.779 128.260 1.00 52.83  ? 127 TYR A CZ  1 
ATOM 965  O OH  . TYR A 1 127 ? 98.982  153.019 129.587 1.00 62.38  ? 127 TYR A OH  1 
ATOM 966  N N   . ALA A 1 128 ? 100.383 152.703 120.992 1.00 38.48  ? 128 ALA A N   1 
ATOM 967  C CA  . ALA A 1 128 ? 101.157 153.108 119.822 1.00 26.73  ? 128 ALA A CA  1 
ATOM 968  C C   . ALA A 1 128 ? 100.598 154.384 119.209 1.00 32.77  ? 128 ALA A C   1 
ATOM 969  O O   . ALA A 1 128 ? 101.358 155.248 118.758 1.00 45.88  ? 128 ALA A O   1 
ATOM 970  C CB  . ALA A 1 128 ? 101.181 151.985 118.788 1.00 36.55  ? 128 ALA A CB  1 
ATOM 971  N N   . GLN A 1 129 ? 99.270  154.528 119.195 1.00 47.76  ? 129 GLN A N   1 
ATOM 972  C CA  . GLN A 1 129 ? 98.664  155.770 118.720 1.00 54.73  ? 129 GLN A CA  1 
ATOM 973  C C   . GLN A 1 129 ? 99.015  156.948 119.627 1.00 52.90  ? 129 GLN A C   1 
ATOM 974  O O   . GLN A 1 129 ? 99.251  158.063 119.142 1.00 53.70  ? 129 GLN A O   1 
ATOM 975  C CB  . GLN A 1 129 ? 97.150  155.604 118.610 1.00 53.17  ? 129 GLN A CB  1 
ATOM 976  C CG  . GLN A 1 129 ? 96.440  156.800 118.006 1.00 57.03  ? 129 GLN A CG  1 
ATOM 977  C CD  . GLN A 1 129 ? 95.169  156.417 117.283 1.00 55.66  ? 129 GLN A CD  1 
ATOM 978  O OE1 . GLN A 1 129 ? 94.109  156.994 117.518 1.00 55.37  ? 129 GLN A OE1 1 
ATOM 979  N NE2 . GLN A 1 129 ? 95.269  155.441 116.389 1.00 51.73  ? 129 GLN A NE2 1 
ATOM 980  N N   . ARG A 1 130 ? 99.047  156.720 120.945 1.00 53.82  ? 130 ARG A N   1 
ATOM 981  C CA  . ARG A 1 130 ? 99.440  157.774 121.880 1.00 53.03  ? 130 ARG A CA  1 
ATOM 982  C C   . ARG A 1 130 ? 100.880 158.219 121.643 1.00 56.33  ? 130 ARG A C   1 
ATOM 983  O O   . ARG A 1 130 ? 101.172 159.424 121.629 1.00 61.58  ? 130 ARG A O   1 
ATOM 984  C CB  . ARG A 1 130 ? 99.260  157.290 123.320 1.00 56.58  ? 130 ARG A CB  1 
ATOM 985  C CG  . ARG A 1 130 ? 100.173 157.965 124.340 1.00 57.44  ? 130 ARG A CG  1 
ATOM 986  C CD  . ARG A 1 130 ? 99.532  158.017 125.718 1.00 54.62  ? 130 ARG A CD  1 
ATOM 987  N NE  . ARG A 1 130 ? 100.268 158.880 126.634 1.00 56.51  ? 130 ARG A NE  1 
ATOM 988  C CZ  . ARG A 1 130 ? 100.032 160.175 126.799 1.00 56.60  ? 130 ARG A CZ  1 
ATOM 989  N NH1 . ARG A 1 130 ? 99.080  160.795 126.122 1.00 59.76  ? 130 ARG A NH1 1 
ATOM 990  N NH2 . ARG A 1 130 ? 100.769 160.864 127.666 1.00 56.40  ? 130 ARG A NH2 1 
ATOM 991  N N   . LEU A 1 131 ? 101.786 157.257 121.438 1.00 58.16  ? 131 LEU A N   1 
ATOM 992  C CA  . LEU A 1 131 ? 103.175 157.581 121.112 1.00 61.01  ? 131 LEU A CA  1 
ATOM 993  C C   . LEU A 1 131 ? 103.271 158.337 119.793 1.00 53.20  ? 131 LEU A C   1 
ATOM 994  O O   . LEU A 1 131 ? 104.090 159.252 119.645 1.00 59.66  ? 131 LEU A O   1 
ATOM 995  C CB  . LEU A 1 131 ? 104.006 156.298 121.043 1.00 61.40  ? 131 LEU A CB  1 
ATOM 996  C CG  . LEU A 1 131 ? 105.460 156.397 120.581 1.00 58.99  ? 131 LEU A CG  1 
ATOM 997  C CD1 . LEU A 1 131 ? 106.372 155.642 121.528 1.00 59.66  ? 131 LEU A CD1 1 
ATOM 998  C CD2 . LEU A 1 131 ? 105.609 155.866 119.169 1.00 58.58  ? 131 LEU A CD2 1 
ATOM 999  N N   . LEU A 1 132 ? 102.449 157.947 118.822 1.00 48.00  ? 132 LEU A N   1 
ATOM 1000 C CA  . LEU A 1 132 ? 102.435 158.588 117.515 1.00 46.44  ? 132 LEU A CA  1 
ATOM 1001 C C   . LEU A 1 132 ? 102.014 160.047 117.606 1.00 61.97  ? 132 LEU A C   1 
ATOM 1002 O O   . LEU A 1 132 ? 102.596 160.914 116.944 1.00 59.27  ? 132 LEU A O   1 
ATOM 1003 C CB  . LEU A 1 132 ? 101.484 157.811 116.619 1.00 50.64  ? 132 LEU A CB  1 
ATOM 1004 C CG  . LEU A 1 132 ? 101.467 157.996 115.123 1.00 47.91  ? 132 LEU A CG  1 
ATOM 1005 C CD1 . LEU A 1 132 ? 102.856 158.333 114.635 1.00 50.56  ? 132 LEU A CD1 1 
ATOM 1006 C CD2 . LEU A 1 132 ? 101.012 156.654 114.621 1.00 54.96  ? 132 LEU A CD2 1 
ATOM 1007 N N   . VAL A 1 133 ? 100.985 160.330 118.405 1.00 77.88  ? 133 VAL A N   1 
ATOM 1008 C CA  . VAL A 1 133 ? 100.534 161.708 118.577 1.00 64.91  ? 133 VAL A CA  1 
ATOM 1009 C C   . VAL A 1 133 ? 101.563 162.514 119.365 1.00 65.25  ? 133 VAL A C   1 
ATOM 1010 O O   . VAL A 1 133 ? 101.830 163.681 119.047 1.00 63.44  ? 133 VAL A O   1 
ATOM 1011 C CB  . VAL A 1 133 ? 99.145  161.731 119.246 1.00 64.77  ? 133 VAL A CB  1 
ATOM 1012 C CG1 . VAL A 1 133 ? 98.692  163.155 119.522 1.00 65.10  ? 133 VAL A CG1 1 
ATOM 1013 C CG2 . VAL A 1 133 ? 98.126  161.029 118.362 1.00 61.92  ? 133 VAL A CG2 1 
ATOM 1014 N N   . THR A 1 134 ? 102.175 161.899 120.383 1.00 72.95  ? 134 THR A N   1 
ATOM 1015 C CA  . THR A 1 134 ? 103.078 162.628 121.273 1.00 73.28  ? 134 THR A CA  1 
ATOM 1016 C C   . THR A 1 134 ? 104.352 163.082 120.561 1.00 70.56  ? 134 THR A C   1 
ATOM 1017 O O   . THR A 1 134 ? 104.837 164.194 120.801 1.00 69.99  ? 134 THR A O   1 
ATOM 1018 C CB  . THR A 1 134 ? 103.422 161.764 122.488 1.00 69.34  ? 134 THR A CB  1 
ATOM 1019 O OG1 . THR A 1 134 ? 102.221 161.194 123.025 1.00 68.64  ? 134 THR A OG1 1 
ATOM 1020 C CG2 . THR A 1 134 ? 104.097 162.595 123.568 1.00 69.48  ? 134 THR A CG2 1 
ATOM 1021 N N   . ASN A 1 135 ? 104.903 162.252 119.679 1.00 71.82  ? 135 ASN A N   1 
ATOM 1022 C CA  . ASN A 1 135 ? 106.186 162.563 119.064 1.00 73.56  ? 135 ASN A CA  1 
ATOM 1023 C C   . ASN A 1 135 ? 106.013 163.303 117.738 1.00 73.79  ? 135 ASN A C   1 
ATOM 1024 O O   . ASN A 1 135 ? 104.911 163.442 117.204 1.00 73.53  ? 135 ASN A O   1 
ATOM 1025 C CB  . ASN A 1 135 ? 107.008 161.289 118.845 1.00 76.40  ? 135 ASN A CB  1 
ATOM 1026 C CG  . ASN A 1 135 ? 106.680 160.592 117.537 1.00 78.12  ? 135 ASN A CG  1 
ATOM 1027 O OD1 . ASN A 1 135 ? 105.516 160.328 117.230 1.00 72.71  ? 135 ASN A OD1 1 
ATOM 1028 N ND2 . ASN A 1 135 ? 107.710 160.295 116.754 1.00 74.59  ? 135 ASN A ND2 1 
ATOM 1029 N N   . ARG A 1 136 ? 107.135 163.786 117.216 1.00 81.82  ? 136 ARG A N   1 
ATOM 1030 C CA  . ARG A 1 136 ? 107.178 164.378 115.885 1.00 82.67  ? 136 ARG A CA  1 
ATOM 1031 C C   . ARG A 1 136 ? 107.267 163.269 114.843 1.00 79.90  ? 136 ARG A C   1 
ATOM 1032 O O   . ARG A 1 136 ? 108.153 162.412 114.943 1.00 79.39  ? 136 ARG A O   1 
ATOM 1033 C CB  . ARG A 1 136 ? 108.370 165.325 115.773 1.00 81.20  ? 136 ARG A CB  1 
ATOM 1034 C CG  . ARG A 1 136 ? 108.956 165.534 114.374 1.00 79.91  ? 136 ARG A CG  1 
ATOM 1035 C CD  . ARG A 1 136 ? 108.101 166.441 113.499 1.00 81.32  ? 136 ARG A CD  1 
ATOM 1036 N NE  . ARG A 1 136 ? 107.408 165.701 112.452 1.00 80.54  ? 136 ARG A NE  1 
ATOM 1037 C CZ  . ARG A 1 136 ? 106.621 166.252 111.538 1.00 79.64  ? 136 ARG A CZ  1 
ATOM 1038 N NH1 . ARG A 1 136 ? 106.402 167.557 111.511 1.00 79.95  ? 136 ARG A NH1 1 
ATOM 1039 N NH2 . ARG A 1 136 ? 106.039 165.475 110.630 1.00 79.67  ? 136 ARG A NH2 1 
ATOM 1040 N N   . PRO A 1 137 ? 106.357 163.214 113.872 1.00 83.72  ? 137 PRO A N   1 
ATOM 1041 C CA  . PRO A 1 137 ? 106.471 162.214 112.804 1.00 81.07  ? 137 PRO A CA  1 
ATOM 1042 C C   . PRO A 1 137 ? 107.725 162.415 111.966 1.00 81.66  ? 137 PRO A C   1 
ATOM 1043 O O   . PRO A 1 137 ? 108.239 163.524 111.806 1.00 83.26  ? 137 PRO A O   1 
ATOM 1044 C CB  . PRO A 1 137 ? 105.208 162.421 111.959 1.00 78.73  ? 137 PRO A CB  1 
ATOM 1045 C CG  . PRO A 1 137 ? 104.311 163.294 112.740 1.00 80.19  ? 137 PRO A CG  1 
ATOM 1046 C CD  . PRO A 1 137 ? 105.048 163.890 113.892 1.00 82.05  ? 137 PRO A CD  1 
ATOM 1047 N N   . GLY A 1 138 ? 108.218 161.301 111.429 1.00 75.17  ? 138 GLY A N   1 
ATOM 1048 C CA  . GLY A 1 138 ? 109.451 161.262 110.682 1.00 74.06  ? 138 GLY A CA  1 
ATOM 1049 C C   . GLY A 1 138 ? 110.612 160.645 111.431 1.00 76.23  ? 138 GLY A C   1 
ATOM 1050 O O   . GLY A 1 138 ? 111.558 160.164 110.796 1.00 70.16  ? 138 GLY A O   1 
ATOM 1051 N N   . VAL A 1 139 ? 110.561 160.639 112.760 1.00 79.64  ? 139 VAL A N   1 
ATOM 1052 C CA  . VAL A 1 139 ? 111.548 159.964 113.592 1.00 72.89  ? 139 VAL A CA  1 
ATOM 1053 C C   . VAL A 1 139 ? 110.815 158.929 114.439 1.00 71.32  ? 139 VAL A C   1 
ATOM 1054 O O   . VAL A 1 139 ? 109.800 159.237 115.078 1.00 72.56  ? 139 VAL A O   1 
ATOM 1055 C CB  . VAL A 1 139 ? 112.362 160.958 114.445 1.00 72.81  ? 139 VAL A CB  1 
ATOM 1056 C CG1 . VAL A 1 139 ? 111.475 161.995 115.132 1.00 76.73  ? 139 VAL A CG1 1 
ATOM 1057 C CG2 . VAL A 1 139 ? 113.204 160.217 115.471 1.00 72.61  ? 139 VAL A CG2 1 
ATOM 1058 N N   . LEU A 1 140 ? 111.292 157.686 114.394 1.00 67.52  ? 140 LEU A N   1 
ATOM 1059 C CA  . LEU A 1 140 ? 110.608 156.601 115.080 1.00 65.50  ? 140 LEU A CA  1 
ATOM 1060 C C   . LEU A 1 140 ? 111.070 156.435 116.519 1.00 69.11  ? 140 LEU A C   1 
ATOM 1061 O O   . LEU A 1 140 ? 110.595 155.523 117.202 1.00 68.17  ? 140 LEU A O   1 
ATOM 1062 C CB  . LEU A 1 140 ? 110.794 155.280 114.327 1.00 66.00  ? 140 LEU A CB  1 
ATOM 1063 C CG  . LEU A 1 140 ? 110.658 155.252 112.798 1.00 65.23  ? 140 LEU A CG  1 
ATOM 1064 C CD1 . LEU A 1 140 ? 112.003 155.422 112.100 1.00 67.38  ? 140 LEU A CD1 1 
ATOM 1065 C CD2 . LEU A 1 140 ? 109.934 154.007 112.299 1.00 67.21  ? 140 LEU A CD2 1 
ATOM 1066 N N   . PHE A 1 141 ? 111.984 157.278 116.983 1.00 74.30  ? 141 PHE A N   1 
ATOM 1067 C CA  . PHE A 1 141 ? 112.428 157.304 118.365 1.00 68.61  ? 141 PHE A CA  1 
ATOM 1068 C C   . PHE A 1 141 ? 111.944 158.593 119.023 1.00 75.73  ? 141 PHE A C   1 
ATOM 1069 O O   . PHE A 1 141 ? 111.205 159.383 118.425 1.00 74.85  ? 141 PHE A O   1 
ATOM 1070 C CB  . PHE A 1 141 ? 113.949 157.160 118.435 1.00 68.72  ? 141 PHE A CB  1 
ATOM 1071 C CG  . PHE A 1 141 ? 114.408 155.764 118.737 1.00 69.01  ? 141 PHE A CG  1 
ATOM 1072 C CD1 . PHE A 1 141 ? 114.476 155.316 120.044 1.00 72.54  ? 141 PHE A CD1 1 
ATOM 1073 C CD2 . PHE A 1 141 ? 114.766 154.899 117.716 1.00 69.82  ? 141 PHE A CD2 1 
ATOM 1074 C CE1 . PHE A 1 141 ? 114.895 154.033 120.332 1.00 70.66  ? 141 PHE A CE1 1 
ATOM 1075 C CE2 . PHE A 1 141 ? 115.185 153.613 117.997 1.00 66.76  ? 141 PHE A CE2 1 
ATOM 1076 C CZ  . PHE A 1 141 ? 115.242 153.180 119.309 1.00 64.35  ? 141 PHE A CZ  1 
ATOM 1077 N N   . PHE A 1 142 ? 112.361 158.808 120.267 1.00 85.78  ? 142 PHE A N   1 
ATOM 1078 C CA  . PHE A 1 142 ? 111.951 159.969 121.042 1.00 84.17  ? 142 PHE A CA  1 
ATOM 1079 C C   . PHE A 1 142 ? 113.153 160.850 121.349 1.00 84.08  ? 142 PHE A C   1 
ATOM 1080 O O   . PHE A 1 142 ? 114.260 160.353 121.576 1.00 86.80  ? 142 PHE A O   1 
ATOM 1081 C CB  . PHE A 1 142 ? 111.267 159.550 122.346 1.00 86.80  ? 142 PHE A CB  1 
ATOM 1082 C CG  . PHE A 1 142 ? 110.117 160.431 122.734 1.00 84.51  ? 142 PHE A CG  1 
ATOM 1083 C CD1 . PHE A 1 142 ? 109.050 160.623 121.872 1.00 83.28  ? 142 PHE A CD1 1 
ATOM 1084 C CD2 . PHE A 1 142 ? 110.108 161.077 123.958 1.00 84.70  ? 142 PHE A CD2 1 
ATOM 1085 C CE1 . PHE A 1 142 ? 107.993 161.438 122.230 1.00 86.51  ? 142 PHE A CE1 1 
ATOM 1086 C CE2 . PHE A 1 142 ? 109.055 161.894 124.318 1.00 84.61  ? 142 PHE A CE2 1 
ATOM 1087 C CZ  . PHE A 1 142 ? 107.996 162.074 123.453 1.00 84.18  ? 142 PHE A CZ  1 
ATOM 1088 N N   . GLU A 1 143 ? 112.924 162.162 121.352 1.00 83.26  ? 143 GLU A N   1 
ATOM 1089 C CA  . GLU A 1 143 ? 113.956 163.145 121.652 1.00 86.54  ? 143 GLU A CA  1 
ATOM 1090 C C   . GLU A 1 143 ? 113.922 163.622 123.099 1.00 88.20  ? 143 GLU A C   1 
ATOM 1091 O O   . GLU A 1 143 ? 114.715 164.494 123.468 1.00 87.25  ? 143 GLU A O   1 
ATOM 1092 C CB  . GLU A 1 143 ? 113.824 164.346 120.707 1.00 87.93  ? 143 GLU A CB  1 
ATOM 1093 C CG  . GLU A 1 143 ? 112.677 165.292 121.043 1.00 88.63  ? 143 GLU A CG  1 
ATOM 1094 C CD  . GLU A 1 143 ? 111.342 164.817 120.502 1.00 87.42  ? 143 GLU A CD  1 
ATOM 1095 O OE1 . GLU A 1 143 ? 111.328 163.856 119.705 1.00 87.64  ? 143 GLU A OE1 1 
ATOM 1096 O OE2 . GLU A 1 143 ? 110.305 165.404 120.877 1.00 88.35  ? 143 GLU A OE2 1 
ATOM 1097 N N   . GLY A 1 144 ? 113.036 163.067 123.927 1.00 96.53  ? 144 GLY A N   1 
ATOM 1098 C CA  . GLY A 1 144 ? 112.885 163.534 125.287 1.00 98.47  ? 144 GLY A CA  1 
ATOM 1099 C C   . GLY A 1 144 ? 114.009 163.090 126.204 1.00 98.34  ? 144 GLY A C   1 
ATOM 1100 O O   . GLY A 1 144 ? 114.901 162.329 125.831 1.00 94.48  ? 144 GLY A O   1 
ATOM 1101 N N   . ASP A 1 145 ? 113.950 163.584 127.439 1.00 105.28 ? 145 ASP A N   1 
ATOM 1102 C CA  . ASP A 1 145 ? 114.976 163.305 128.431 1.00 104.27 ? 145 ASP A CA  1 
ATOM 1103 C C   . ASP A 1 145 ? 114.762 161.924 129.050 1.00 101.02 ? 145 ASP A C   1 
ATOM 1104 O O   . ASP A 1 145 ? 113.922 161.135 128.610 1.00 98.93  ? 145 ASP A O   1 
ATOM 1105 C CB  . ASP A 1 145 ? 114.988 164.395 129.500 1.00 100.44 ? 145 ASP A CB  1 
ATOM 1106 C CG  . ASP A 1 145 ? 116.391 164.751 129.954 1.00 100.51 ? 145 ASP A CG  1 
ATOM 1107 O OD1 . ASP A 1 145 ? 117.212 163.827 130.129 1.00 101.53 ? 145 ASP A OD1 1 
ATOM 1108 O OD2 . ASP A 1 145 ? 116.673 165.954 130.132 1.00 104.24 ? 145 ASP A OD2 1 
ATOM 1109 N N   . GLU A 1 146 ? 115.542 161.630 130.093 1.00 94.37  ? 146 GLU A N   1 
ATOM 1110 C CA  . GLU A 1 146 ? 115.519 160.296 130.687 1.00 93.49  ? 146 GLU A CA  1 
ATOM 1111 C C   . GLU A 1 146 ? 114.263 160.066 131.520 1.00 94.76  ? 146 GLU A C   1 
ATOM 1112 O O   . GLU A 1 146 ? 113.703 158.963 131.508 1.00 93.76  ? 146 GLU A O   1 
ATOM 1113 C CB  . GLU A 1 146 ? 116.771 160.084 131.539 1.00 95.10  ? 146 GLU A CB  1 
ATOM 1114 C CG  . GLU A 1 146 ? 118.020 159.754 130.738 1.00 93.88  ? 146 GLU A CG  1 
ATOM 1115 C CD  . GLU A 1 146 ? 119.289 159.881 131.559 1.00 95.75  ? 146 GLU A CD  1 
ATOM 1116 O OE1 . GLU A 1 146 ? 119.482 159.068 132.487 1.00 96.06  ? 146 GLU A OE1 1 
ATOM 1117 O OE2 . GLU A 1 146 ? 120.095 160.791 131.274 1.00 93.50  ? 146 GLU A OE2 1 
ATOM 1118 N N   . GLY A 1 147 ? 113.817 161.085 132.260 1.00 96.29  ? 147 GLY A N   1 
ATOM 1119 C CA  . GLY A 1 147 ? 112.695 160.896 133.170 1.00 93.75  ? 147 GLY A CA  1 
ATOM 1120 C C   . GLY A 1 147 ? 111.384 160.623 132.456 1.00 92.28  ? 147 GLY A C   1 
ATOM 1121 O O   . GLY A 1 147 ? 110.641 159.707 132.825 1.00 89.79  ? 147 GLY A O   1 
ATOM 1122 N N   . LEU A 1 148 ? 111.091 161.397 131.409 1.00 94.49  ? 148 LEU A N   1 
ATOM 1123 C CA  . LEU A 1 148 ? 109.837 161.203 130.687 1.00 95.95  ? 148 LEU A CA  1 
ATOM 1124 C C   . LEU A 1 148 ? 109.860 159.920 129.864 1.00 97.09  ? 148 LEU A C   1 
ATOM 1125 O O   . LEU A 1 148 ? 108.828 159.254 129.732 1.00 99.42  ? 148 LEU A O   1 
ATOM 1126 C CB  . LEU A 1 148 ? 109.549 162.415 129.800 1.00 95.34  ? 148 LEU A CB  1 
ATOM 1127 C CG  . LEU A 1 148 ? 108.139 162.539 129.214 1.00 94.89  ? 148 LEU A CG  1 
ATOM 1128 C CD1 . LEU A 1 148 ? 107.654 163.977 129.314 1.00 94.68  ? 148 LEU A CD1 1 
ATOM 1129 C CD2 . LEU A 1 148 ? 108.094 162.068 127.770 1.00 95.40  ? 148 LEU A CD2 1 
ATOM 1130 N N   . THR A 1 149 ? 111.022 159.558 129.314 1.00 92.79  ? 149 THR A N   1 
ATOM 1131 C CA  . THR A 1 149 ? 111.155 158.288 128.605 1.00 93.70  ? 149 THR A CA  1 
ATOM 1132 C C   . THR A 1 149 ? 110.963 157.108 129.555 1.00 93.27  ? 149 THR A C   1 
ATOM 1133 O O   . THR A 1 149 ? 110.294 156.127 129.208 1.00 91.94  ? 149 THR A O   1 
ATOM 1134 C CB  . THR A 1 149 ? 112.517 158.232 127.904 1.00 95.91  ? 149 THR A CB  1 
ATOM 1135 O OG1 . THR A 1 149 ? 112.469 159.019 126.708 1.00 97.79  ? 149 THR A OG1 1 
ATOM 1136 C CG2 . THR A 1 149 ? 112.910 156.808 127.541 1.00 94.15  ? 149 THR A CG2 1 
ATOM 1137 N N   . ALA A 1 150 ? 111.519 157.200 130.768 1.00 87.90  ? 150 ALA A N   1 
ATOM 1138 C CA  . ALA A 1 150 ? 111.295 156.166 131.774 1.00 87.53  ? 150 ALA A CA  1 
ATOM 1139 C C   . ALA A 1 150 ? 109.831 156.091 132.190 1.00 87.26  ? 150 ALA A C   1 
ATOM 1140 O O   . ALA A 1 150 ? 109.306 154.990 132.403 1.00 84.05  ? 150 ALA A O   1 
ATOM 1141 C CB  . ALA A 1 150 ? 112.181 156.418 132.993 1.00 87.23  ? 150 ALA A CB  1 
ATOM 1142 N N   . ASP A 1 151 ? 109.163 157.244 132.308 1.00 85.41  ? 151 ASP A N   1 
ATOM 1143 C CA  . ASP A 1 151 ? 107.732 157.258 132.603 1.00 87.25  ? 151 ASP A CA  1 
ATOM 1144 C C   . ASP A 1 151 ? 106.934 156.581 131.495 1.00 88.02  ? 151 ASP A C   1 
ATOM 1145 O O   . ASP A 1 151 ? 106.016 155.799 131.770 1.00 94.09  ? 151 ASP A O   1 
ATOM 1146 C CB  . ASP A 1 151 ? 107.259 158.699 132.802 1.00 88.35  ? 151 ASP A CB  1 
ATOM 1147 C CG  . ASP A 1 151 ? 105.765 158.801 133.058 1.00 87.52  ? 151 ASP A CG  1 
ATOM 1148 O OD1 . ASP A 1 151 ? 105.189 157.871 133.661 1.00 87.39  ? 151 ASP A OD1 1 
ATOM 1149 O OD2 . ASP A 1 151 ? 105.164 159.817 132.650 1.00 87.20  ? 151 ASP A OD2 1 
ATOM 1150 N N   . PHE A 1 152 ? 107.282 156.864 130.237 1.00 82.18  ? 152 PHE A N   1 
ATOM 1151 C CA  . PHE A 1 152 ? 106.621 156.230 129.099 1.00 84.78  ? 152 PHE A CA  1 
ATOM 1152 C C   . PHE A 1 152 ? 106.835 154.722 129.102 1.00 84.17  ? 152 PHE A C   1 
ATOM 1153 O O   . PHE A 1 152 ? 105.897 153.950 128.860 1.00 86.15  ? 152 PHE A O   1 
ATOM 1154 C CB  . PHE A 1 152 ? 107.150 156.838 127.798 1.00 86.55  ? 152 PHE A CB  1 
ATOM 1155 C CG  . PHE A 1 152 ? 106.193 156.749 126.646 1.00 86.00  ? 152 PHE A CG  1 
ATOM 1156 C CD1 . PHE A 1 152 ? 106.014 155.557 125.964 1.00 84.71  ? 152 PHE A CD1 1 
ATOM 1157 C CD2 . PHE A 1 152 ? 105.489 157.867 126.232 1.00 83.98  ? 152 PHE A CD2 1 
ATOM 1158 C CE1 . PHE A 1 152 ? 105.139 155.476 124.907 1.00 85.89  ? 152 PHE A CE1 1 
ATOM 1159 C CE2 . PHE A 1 152 ? 104.615 157.793 125.170 1.00 82.95  ? 152 PHE A CE2 1 
ATOM 1160 C CZ  . PHE A 1 152 ? 104.439 156.597 124.510 1.00 84.65  ? 152 PHE A CZ  1 
ATOM 1161 N N   . LEU A 1 153 ? 108.067 154.287 129.376 1.00 78.74  ? 153 LEU A N   1 
ATOM 1162 C CA  . LEU A 1 153 ? 108.373 152.863 129.382 1.00 79.07  ? 153 LEU A CA  1 
ATOM 1163 C C   . LEU A 1 153 ? 107.644 152.143 130.507 1.00 79.95  ? 153 LEU A C   1 
ATOM 1164 O O   . LEU A 1 153 ? 107.132 151.037 130.307 1.00 76.72  ? 153 LEU A O   1 
ATOM 1165 C CB  . LEU A 1 153 ? 109.881 152.649 129.496 1.00 81.66  ? 153 LEU A CB  1 
ATOM 1166 C CG  . LEU A 1 153 ? 110.472 151.411 128.815 1.00 81.00  ? 153 LEU A CG  1 
ATOM 1167 C CD1 . LEU A 1 153 ? 109.706 151.034 127.555 1.00 76.99  ? 153 LEU A CD1 1 
ATOM 1168 C CD2 . LEU A 1 153 ? 111.940 151.638 128.500 1.00 84.44  ? 153 LEU A CD2 1 
ATOM 1169 N N   . ARG A 1 154 ? 107.574 152.758 131.692 1.00 82.05  ? 154 ARG A N   1 
ATOM 1170 C CA  . ARG A 1 154 ? 106.841 152.146 132.797 1.00 82.15  ? 154 ARG A CA  1 
ATOM 1171 C C   . ARG A 1 154 ? 105.343 152.101 132.515 1.00 82.50  ? 154 ARG A C   1 
ATOM 1172 O O   . ARG A 1 154 ? 104.675 151.109 132.838 1.00 82.13  ? 154 ARG A O   1 
ATOM 1173 C CB  . ARG A 1 154 ? 107.122 152.898 134.099 0.16 80.76  ? 154 ARG A CB  1 
ATOM 1174 C CG  . ARG A 1 154 ? 108.478 152.588 134.721 1.00 82.47  ? 154 ARG A CG  1 
ATOM 1175 C CD  . ARG A 1 154 ? 108.626 151.112 135.097 1.00 82.07  ? 154 ARG A CD  1 
ATOM 1176 N NE  . ARG A 1 154 ? 107.410 150.527 135.653 1.00 82.74  ? 154 ARG A NE  1 
ATOM 1177 C CZ  . ARG A 1 154 ? 106.958 150.740 136.882 1.00 81.37  ? 154 ARG A CZ  1 
ATOM 1178 N NH1 . ARG A 1 154 ? 107.612 151.508 137.738 1.00 83.74  ? 154 ARG A NH1 1 
ATOM 1179 N NH2 . ARG A 1 154 ? 105.823 150.161 137.265 1.00 81.44  ? 154 ARG A NH2 1 
ATOM 1180 N N   . GLU A 1 155 ? 104.806 153.161 131.900 1.00 71.62  ? 155 GLU A N   1 
ATOM 1181 C CA  . GLU A 1 155 ? 103.386 153.202 131.571 1.00 66.26  ? 155 GLU A CA  1 
ATOM 1182 C C   . GLU A 1 155 ? 103.022 152.134 130.546 1.00 67.68  ? 155 GLU A C   1 
ATOM 1183 O O   . GLU A 1 155 ? 101.964 151.502 130.649 1.00 69.46  ? 155 GLU A O   1 
ATOM 1184 C CB  . GLU A 1 155 ? 103.016 154.604 131.074 1.00 70.61  ? 155 GLU A CB  1 
ATOM 1185 C CG  . GLU A 1 155 ? 102.013 154.660 129.933 1.00 69.82  ? 155 GLU A CG  1 
ATOM 1186 C CD  . GLU A 1 155 ? 101.328 156.008 129.828 1.00 69.68  ? 155 GLU A CD  1 
ATOM 1187 O OE1 . GLU A 1 155 ? 101.966 157.028 130.163 1.00 72.90  ? 155 GLU A OE1 1 
ATOM 1188 O OE2 . GLU A 1 155 ? 100.151 156.047 129.411 1.00 69.56  ? 155 GLU A OE2 1 
ATOM 1189 N N   . TYR A 1 156 ? 103.894 151.898 129.562 1.00 68.50  ? 156 TYR A N   1 
ATOM 1190 C CA  . TYR A 1 156 ? 103.619 150.827 128.606 1.00 71.43  ? 156 TYR A CA  1 
ATOM 1191 C C   . TYR A 1 156 ? 103.831 149.448 129.228 1.00 71.01  ? 156 TYR A C   1 
ATOM 1192 O O   . TYR A 1 156 ? 103.052 148.524 128.967 1.00 70.04  ? 156 TYR A O   1 
ATOM 1193 C CB  . TYR A 1 156 ? 104.464 151.008 127.342 1.00 72.98  ? 156 TYR A CB  1 
ATOM 1194 C CG  . TYR A 1 156 ? 105.010 149.724 126.757 1.00 68.60  ? 156 TYR A CG  1 
ATOM 1195 C CD1 . TYR A 1 156 ? 104.198 148.849 126.037 1.00 63.24  ? 156 TYR A CD1 1 
ATOM 1196 C CD2 . TYR A 1 156 ? 106.350 149.400 126.903 1.00 68.90  ? 156 TYR A CD2 1 
ATOM 1197 C CE1 . TYR A 1 156 ? 104.711 147.683 125.504 1.00 64.59  ? 156 TYR A CE1 1 
ATOM 1198 C CE2 . TYR A 1 156 ? 106.867 148.241 126.373 1.00 67.45  ? 156 TYR A CE2 1 
ATOM 1199 C CZ  . TYR A 1 156 ? 106.046 147.386 125.677 1.00 65.67  ? 156 TYR A CZ  1 
ATOM 1200 O OH  . TYR A 1 156 ? 106.570 146.229 125.154 1.00 70.67  ? 156 TYR A OH  1 
ATOM 1201 N N   . VAL A 1 157 ? 104.866 149.282 130.058 1.00 66.19  ? 157 VAL A N   1 
ATOM 1202 C CA  . VAL A 1 157 ? 105.147 147.967 130.633 1.00 65.21  ? 157 VAL A CA  1 
ATOM 1203 C C   . VAL A 1 157 ? 104.189 147.611 131.759 1.00 72.87  ? 157 VAL A C   1 
ATOM 1204 O O   . VAL A 1 157 ? 104.192 146.462 132.223 1.00 74.92  ? 157 VAL A O   1 
ATOM 1205 C CB  . VAL A 1 157 ? 106.612 147.904 131.110 1.00 68.62  ? 157 VAL A CB  1 
ATOM 1206 C CG1 . VAL A 1 157 ? 106.760 148.457 132.524 1.00 69.47  ? 157 VAL A CG1 1 
ATOM 1207 C CG2 . VAL A 1 157 ? 107.171 146.487 130.992 1.00 67.46  ? 157 VAL A CG2 1 
ATOM 1208 N N   . THR A 1 158 ? 103.348 148.555 132.196 1.00 72.02  ? 158 THR A N   1 
ATOM 1209 C CA  . THR A 1 158 ? 102.325 148.252 133.194 1.00 72.15  ? 158 THR A CA  1 
ATOM 1210 C C   . THR A 1 158 ? 101.281 147.257 132.685 1.00 71.43  ? 158 THR A C   1 
ATOM 1211 O O   . THR A 1 158 ? 100.602 146.622 133.499 1.00 75.55  ? 158 THR A O   1 
ATOM 1212 C CB  . THR A 1 158 ? 101.637 149.547 133.642 1.00 71.72  ? 158 THR A CB  1 
ATOM 1213 O OG1 . THR A 1 158 ? 102.588 150.619 133.636 1.00 72.34  ? 158 THR A OG1 1 
ATOM 1214 C CG2 . THR A 1 158 ? 101.079 149.406 135.054 1.00 72.68  ? 158 THR A CG2 1 
ATOM 1215 N N   . LEU A 1 159 ? 101.149 147.095 131.368 1.00 69.73  ? 159 LEU A N   1 
ATOM 1216 C CA  . LEU A 1 159 ? 100.170 146.171 130.810 1.00 72.25  ? 159 LEU A CA  1 
ATOM 1217 C C   . LEU A 1 159 ? 100.530 144.721 131.124 1.00 69.42  ? 159 LEU A C   1 
ATOM 1218 O O   . LEU A 1 159 ? 101.674 144.394 131.451 1.00 68.68  ? 159 LEU A O   1 
ATOM 1219 C CB  . LEU A 1 159 ? 100.054 146.355 129.297 1.00 68.59  ? 159 LEU A CB  1 
ATOM 1220 C CG  . LEU A 1 159 ? 99.317  147.596 128.795 1.00 69.09  ? 159 LEU A CG  1 
ATOM 1221 C CD1 . LEU A 1 159 ? 99.019  147.453 127.317 1.00 70.37  ? 159 LEU A CD1 1 
ATOM 1222 C CD2 . LEU A 1 159 ? 98.036  147.831 129.575 1.00 64.15  ? 159 LEU A CD2 1 
ATOM 1223 N N   . HIS A 1 160 ? 99.530  143.851 131.019 1.00 70.66  ? 160 HIS A N   1 
ATOM 1224 C CA  . HIS A 1 160 ? 99.635  142.458 131.426 1.00 69.68  ? 160 HIS A CA  1 
ATOM 1225 C C   . HIS A 1 160 ? 99.444  141.577 130.199 1.00 69.37  ? 160 HIS A C   1 
ATOM 1226 O O   . HIS A 1 160 ? 98.632  141.887 129.322 1.00 69.75  ? 160 HIS A O   1 
ATOM 1227 C CB  . HIS A 1 160 ? 98.609  142.172 132.537 1.00 69.44  ? 160 HIS A CB  1 
ATOM 1228 C CG  . HIS A 1 160 ? 98.390  140.723 132.857 1.00 71.96  ? 160 HIS A CG  1 
ATOM 1229 N ND1 . HIS A 1 160 ? 97.728  139.850 132.021 1.00 71.79  ? 160 HIS A ND1 1 
ATOM 1230 C CD2 . HIS A 1 160 ? 98.740  140.002 133.948 1.00 73.04  ? 160 HIS A CD2 1 
ATOM 1231 C CE1 . HIS A 1 160 ? 97.677  138.657 132.585 1.00 71.27  ? 160 HIS A CE1 1 
ATOM 1232 N NE2 . HIS A 1 160 ? 98.290  138.720 133.752 1.00 71.52  ? 160 HIS A NE2 1 
ATOM 1233 N N   . LYS A 1 161 ? 100.194 140.477 130.143 1.00 74.48  ? 161 LYS A N   1 
ATOM 1234 C CA  . LYS A 1 161 ? 100.378 139.730 128.903 1.00 75.74  ? 161 LYS A CA  1 
ATOM 1235 C C   . LYS A 1 161 ? 99.858  138.299 129.001 1.00 76.38  ? 161 LYS A C   1 
ATOM 1236 O O   . LYS A 1 161 ? 100.551 137.351 128.616 1.00 68.79  ? 161 LYS A O   1 
ATOM 1237 C CB  . LYS A 1 161 ? 101.859 139.735 128.511 1.00 66.41  ? 161 LYS A CB  1 
ATOM 1238 C CG  . LYS A 1 161 ? 102.807 139.427 129.664 1.00 69.29  ? 161 LYS A CG  1 
ATOM 1239 C CD  . LYS A 1 161 ? 104.151 140.113 129.500 1.00 68.32  ? 161 LYS A CD  1 
ATOM 1240 C CE  . LYS A 1 161 ? 104.155 141.485 130.146 1.00 69.19  ? 161 LYS A CE  1 
ATOM 1241 N NZ  . LYS A 1 161 ? 103.676 141.434 131.554 1.00 69.59  ? 161 LYS A NZ  1 
ATOM 1242 N N   . GLY A 1 162 ? 98.631  138.133 129.492 1.00 70.03  ? 162 GLY A N   1 
ATOM 1243 C CA  . GLY A 1 162 ? 98.078  136.818 129.763 1.00 70.06  ? 162 GLY A CA  1 
ATOM 1244 C C   . GLY A 1 162 ? 97.640  135.995 128.571 1.00 74.12  ? 162 GLY A C   1 
ATOM 1245 O O   . GLY A 1 162 ? 97.074  134.910 128.736 1.00 69.93  ? 162 GLY A O   1 
ATOM 1246 N N   . CYS A 1 163 ? 97.896  136.490 127.367 1.00 68.59  ? 163 CYS A N   1 
ATOM 1247 C CA  . CYS A 1 163 ? 97.396  135.872 126.148 1.00 67.74  ? 163 CYS A CA  1 
ATOM 1248 C C   . CYS A 1 163 ? 98.501  135.398 125.218 1.00 65.44  ? 163 CYS A C   1 
ATOM 1249 O O   . CYS A 1 163 ? 98.407  134.292 124.671 1.00 62.39  ? 163 CYS A O   1 
ATOM 1250 C CB  . CYS A 1 163 ? 96.488  136.869 125.429 1.00 61.17  ? 163 CYS A CB  1 
ATOM 1251 S SG  . CYS A 1 163 ? 97.414  138.248 124.769 1.00 61.42  ? 163 CYS A SG  1 
ATOM 1252 N N   . PHE A 1 164 ? 99.542  136.209 125.005 1.00 58.96  ? 164 PHE A N   1 
ATOM 1253 C CA  . PHE A 1 164 ? 100.624 135.795 124.116 1.00 52.00  ? 164 PHE A CA  1 
ATOM 1254 C C   . PHE A 1 164 ? 101.473 134.694 124.736 1.00 58.09  ? 164 PHE A C   1 
ATOM 1255 O O   . PHE A 1 164 ? 102.104 133.919 124.010 1.00 58.68  ? 164 PHE A O   1 
ATOM 1256 C CB  . PHE A 1 164 ? 101.519 136.981 123.760 1.00 54.49  ? 164 PHE A CB  1 
ATOM 1257 C CG  . PHE A 1 164 ? 100.798 138.291 123.650 1.00 56.12  ? 164 PHE A CG  1 
ATOM 1258 C CD1 . PHE A 1 164 ? 100.126 138.632 122.489 1.00 58.15  ? 164 PHE A CD1 1 
ATOM 1259 C CD2 . PHE A 1 164 ? 100.827 139.201 124.695 1.00 54.69  ? 164 PHE A CD2 1 
ATOM 1260 C CE1 . PHE A 1 164 ? 99.476  139.847 122.380 1.00 56.83  ? 164 PHE A CE1 1 
ATOM 1261 C CE2 . PHE A 1 164 ? 100.178 140.416 124.593 1.00 56.34  ? 164 PHE A CE2 1 
ATOM 1262 C CZ  . PHE A 1 164 ? 99.503  140.740 123.433 1.00 52.76  ? 164 PHE A CZ  1 
ATOM 1263 N N   . TYR A 1 165 ? 101.511 134.612 126.065 1.00 68.68  ? 165 TYR A N   1 
ATOM 1264 C CA  . TYR A 1 165 ? 102.373 133.673 126.769 1.00 68.26  ? 165 TYR A CA  1 
ATOM 1265 C C   . TYR A 1 165 ? 101.628 132.436 127.246 1.00 63.64  ? 165 TYR A C   1 
ATOM 1266 O O   . TYR A 1 165 ? 102.205 131.616 127.966 1.00 62.45  ? 165 TYR A O   1 
ATOM 1267 C CB  . TYR A 1 165 ? 103.047 134.371 127.951 1.00 67.04  ? 165 TYR A CB  1 
ATOM 1268 C CG  . TYR A 1 165 ? 104.184 135.286 127.548 1.00 67.88  ? 165 TYR A CG  1 
ATOM 1269 C CD1 . TYR A 1 165 ? 104.690 135.269 126.253 1.00 64.60  ? 165 TYR A CD1 1 
ATOM 1270 C CD2 . TYR A 1 165 ? 104.741 136.174 128.457 1.00 65.21  ? 165 TYR A CD2 1 
ATOM 1271 C CE1 . TYR A 1 165 ? 105.720 136.104 125.877 1.00 66.61  ? 165 TYR A CE1 1 
ATOM 1272 C CE2 . TYR A 1 165 ? 105.774 137.015 128.089 1.00 70.24  ? 165 TYR A CE2 1 
ATOM 1273 C CZ  . TYR A 1 165 ? 106.259 136.973 126.798 1.00 66.72  ? 165 TYR A CZ  1 
ATOM 1274 O OH  . TYR A 1 165 ? 107.285 137.808 126.425 1.00 60.72  ? 165 TYR A OH  1 
ATOM 1275 N N   . GLY A 1 166 ? 100.364 132.285 126.867 1.00 64.24  ? 166 GLY A N   1 
ATOM 1276 C CA  . GLY A 1 166 ? 99.604  131.109 127.233 1.00 67.64  ? 166 GLY A CA  1 
ATOM 1277 C C   . GLY A 1 166 ? 99.489  130.131 126.084 1.00 70.36  ? 166 GLY A C   1 
ATOM 1278 O O   . GLY A 1 166 ? 100.502 129.689 125.535 1.00 71.07  ? 166 GLY A O   1 
ATOM 1279 N N   . ARG A 1 167 ? 98.257  129.793 125.705 1.00 68.92  ? 167 ARG A N   1 
ATOM 1280 C CA  . ARG A 1 167 ? 98.033  128.855 124.613 1.00 67.17  ? 167 ARG A CA  1 
ATOM 1281 C C   . ARG A 1 167 ? 98.347  129.462 123.249 1.00 66.62  ? 167 ARG A C   1 
ATOM 1282 O O   . ARG A 1 167 ? 98.770  128.738 122.340 1.00 67.78  ? 167 ARG A O   1 
ATOM 1283 C CB  . ARG A 1 167 ? 96.587  128.338 124.687 1.00 66.23  ? 167 ARG A CB  1 
ATOM 1284 C CG  . ARG A 1 167 ? 95.966  127.851 123.385 1.00 69.04  ? 167 ARG A CG  1 
ATOM 1285 C CD  . ARG A 1 167 ? 95.104  126.627 123.620 1.00 71.54  ? 167 ARG A CD  1 
ATOM 1286 N NE  . ARG A 1 167 ? 93.802  126.960 124.180 1.00 69.54  ? 167 ARG A NE  1 
ATOM 1287 C CZ  . ARG A 1 167 ? 92.821  126.087 124.349 1.00 68.86  ? 167 ARG A CZ  1 
ATOM 1288 N NH1 . ARG A 1 167 ? 92.963  124.815 124.014 1.00 72.31  ? 167 ARG A NH1 1 
ATOM 1289 N NH2 . ARG A 1 167 ? 91.669  126.498 124.867 1.00 65.60  ? 167 ARG A NH2 1 
ATOM 1290 N N   . CYS A 1 168 ? 98.244  130.781 123.113 1.00 66.40  ? 168 CYS A N   1 
ATOM 1291 C CA  . CYS A 1 168 ? 98.410  131.456 121.826 1.00 69.37  ? 168 CYS A CA  1 
ATOM 1292 C C   . CYS A 1 168 ? 99.855  131.855 121.556 1.00 66.04  ? 168 CYS A C   1 
ATOM 1293 O O   . CYS A 1 168 ? 100.109 132.859 120.884 1.00 66.35  ? 168 CYS A O   1 
ATOM 1294 C CB  . CYS A 1 168 ? 97.496  132.675 121.774 0.09 68.03  ? 168 CYS A CB  1 
ATOM 1295 S SG  . CYS A 1 168 ? 95.876  132.417 122.524 1.00 64.76  ? 168 CYS A SG  1 
ATOM 1296 N N   . LEU A 1 169 ? 100.822 131.096 122.072 1.00 67.03  ? 169 LEU A N   1 
ATOM 1297 C CA  . LEU A 1 169 ? 102.242 131.406 121.896 1.00 68.54  ? 169 LEU A CA  1 
ATOM 1298 C C   . LEU A 1 169 ? 102.642 131.117 120.455 1.00 70.83  ? 169 LEU A C   1 
ATOM 1299 O O   . LEU A 1 169 ? 102.851 129.970 120.059 1.00 66.96  ? 169 LEU A O   1 
ATOM 1300 C CB  . LEU A 1 169 ? 103.095 130.607 122.873 1.00 65.16  ? 169 LEU A CB  1 
ATOM 1301 C CG  . LEU A 1 169 ? 104.594 130.923 122.877 1.00 67.00  ? 169 LEU A CG  1 
ATOM 1302 C CD1 . LEU A 1 169 ? 104.844 132.423 122.845 1.00 66.80  ? 169 LEU A CD1 1 
ATOM 1303 C CD2 . LEU A 1 169 ? 105.283 130.301 124.073 1.00 63.41  ? 169 LEU A CD2 1 
ATOM 1304 N N   . GLY A 1 170 ? 102.757 132.177 119.662 1.00 77.98  ? 170 GLY A N   1 
ATOM 1305 C CA  . GLY A 1 170 ? 103.250 132.042 118.309 1.00 73.84  ? 170 GLY A CA  1 
ATOM 1306 C C   . GLY A 1 170 ? 102.177 132.076 117.243 1.00 72.76  ? 170 GLY A C   1 
ATOM 1307 O O   . GLY A 1 170 ? 102.274 131.354 116.247 1.00 74.31  ? 170 GLY A O   1 
ATOM 1308 N N   . PHE A 1 171 ? 101.147 132.902 117.433 1.00 61.68  ? 171 PHE A N   1 
ATOM 1309 C CA  . PHE A 1 171 ? 100.145 133.074 116.390 1.00 63.99  ? 171 PHE A CA  1 
ATOM 1310 C C   . PHE A 1 171 ? 100.649 133.958 115.259 1.00 65.04  ? 171 PHE A C   1 
ATOM 1311 O O   . PHE A 1 171 ? 100.151 133.852 114.134 1.00 66.79  ? 171 PHE A O   1 
ATOM 1312 C CB  . PHE A 1 171 ? 98.829  133.593 117.017 1.00 63.98  ? 171 PHE A CB  1 
ATOM 1313 C CG  . PHE A 1 171 ? 98.831  135.057 117.458 1.00 70.79  ? 171 PHE A CG  1 
ATOM 1314 C CD1 . PHE A 1 171 ? 98.755  136.118 116.553 1.00 65.94  ? 171 PHE A CD1 1 
ATOM 1315 C CD2 . PHE A 1 171 ? 98.921  135.359 118.806 1.00 70.20  ? 171 PHE A CD2 1 
ATOM 1316 C CE1 . PHE A 1 171 ? 98.759  137.426 116.989 1.00 63.06  ? 171 PHE A CE1 1 
ATOM 1317 C CE2 . PHE A 1 171 ? 98.928  136.671 119.244 1.00 66.42  ? 171 PHE A CE2 1 
ATOM 1318 C CZ  . PHE A 1 171 ? 98.847  137.701 118.335 1.00 66.49  ? 171 PHE A CZ  1 
ATOM 1319 N N   . GLN A 1 172 ? 101.624 134.822 115.537 1.00 62.55  ? 172 GLN A N   1 
ATOM 1320 C CA  . GLN A 1 172 ? 102.124 135.768 114.552 1.00 58.44  ? 172 GLN A CA  1 
ATOM 1321 C C   . GLN A 1 172 ? 103.199 135.175 113.655 1.00 65.19  ? 172 GLN A C   1 
ATOM 1322 O O   . GLN A 1 172 ? 103.652 135.855 112.728 1.00 66.25  ? 172 GLN A O   1 
ATOM 1323 C CB  . GLN A 1 172 ? 102.673 137.014 115.253 1.00 61.83  ? 172 GLN A CB  1 
ATOM 1324 C CG  . GLN A 1 172 ? 103.922 136.773 116.087 1.00 62.14  ? 172 GLN A CG  1 
ATOM 1325 C CD  . GLN A 1 172 ? 103.627 136.566 117.558 1.00 58.88  ? 172 GLN A CD  1 
ATOM 1326 O OE1 . GLN A 1 172 ? 102.951 135.614 117.940 1.00 56.35  ? 172 GLN A OE1 1 
ATOM 1327 N NE2 . GLN A 1 172 ? 104.141 137.459 118.395 1.00 57.81  ? 172 GLN A NE2 1 
ATOM 1328 N N   . PHE A 1 173 ? 103.608 133.936 113.902 1.00 70.91  ? 173 PHE A N   1 
ATOM 1329 C CA  . PHE A 1 173 ? 104.656 133.271 113.146 1.00 63.88  ? 173 PHE A CA  1 
ATOM 1330 C C   . PHE A 1 173 ? 104.055 132.218 112.225 1.00 62.40  ? 173 PHE A C   1 
ATOM 1331 O O   . PHE A 1 173 ? 102.836 132.059 112.121 1.00 66.44  ? 173 PHE A O   1 
ATOM 1332 C CB  . PHE A 1 173 ? 105.677 132.630 114.086 1.00 60.83  ? 173 PHE A CB  1 
ATOM 1333 C CG  . PHE A 1 173 ? 106.284 133.587 115.058 1.00 63.03  ? 173 PHE A CG  1 
ATOM 1334 C CD1 . PHE A 1 173 ? 107.098 134.617 114.620 1.00 64.25  ? 173 PHE A CD1 1 
ATOM 1335 C CD2 . PHE A 1 173 ? 106.036 133.461 116.411 1.00 62.29  ? 173 PHE A CD2 1 
ATOM 1336 C CE1 . PHE A 1 173 ? 107.656 135.501 115.518 1.00 65.13  ? 173 PHE A CE1 1 
ATOM 1337 C CE2 . PHE A 1 173 ? 106.585 134.341 117.308 1.00 64.03  ? 173 PHE A CE2 1 
ATOM 1338 C CZ  . PHE A 1 173 ? 107.399 135.361 116.865 1.00 67.95  ? 173 PHE A CZ  1 
ATOM 1339 N N   . THR A 1 174 ? 104.943 131.503 111.547 1.00 57.26  ? 174 THR A N   1 
ATOM 1340 C CA  . THR A 1 174 ? 104.547 130.360 110.750 1.00 65.41  ? 174 THR A CA  1 
ATOM 1341 C C   . THR A 1 174 ? 104.051 129.239 111.664 1.00 67.85  ? 174 THR A C   1 
ATOM 1342 O O   . THR A 1 174 ? 104.595 129.030 112.752 1.00 68.24  ? 174 THR A O   1 
ATOM 1343 C CB  . THR A 1 174 ? 105.733 129.877 109.919 1.00 64.09  ? 174 THR A CB  1 
ATOM 1344 O OG1 . THR A 1 174 ? 106.392 131.011 109.344 1.00 65.68  ? 174 THR A OG1 1 
ATOM 1345 C CG2 . THR A 1 174 ? 105.290 128.948 108.797 1.00 66.07  ? 174 THR A CG2 1 
ATOM 1346 N N   . PRO A 1 175 ? 103.006 128.510 111.256 1.00 65.01  ? 175 PRO A N   1 
ATOM 1347 C CA  . PRO A 1 175 ? 102.579 127.334 112.032 1.00 64.34  ? 175 PRO A CA  1 
ATOM 1348 C C   . PRO A 1 175 ? 103.562 126.170 112.007 1.00 63.79  ? 175 PRO A C   1 
ATOM 1349 O O   . PRO A 1 175 ? 103.334 125.183 112.715 1.00 64.36  ? 175 PRO A O   1 
ATOM 1350 C CB  . PRO A 1 175 ? 101.250 126.940 111.369 1.00 61.31  ? 175 PRO A CB  1 
ATOM 1351 C CG  . PRO A 1 175 ? 100.772 128.176 110.702 1.00 58.38  ? 175 PRO A CG  1 
ATOM 1352 C CD  . PRO A 1 175 ? 101.994 128.916 110.266 1.00 58.57  ? 175 PRO A CD  1 
ATOM 1353 N N   . ALA A 1 176 ? 104.641 126.245 111.229 1.00 56.88  ? 176 ALA A N   1 
ATOM 1354 C CA  . ALA A 1 176 ? 105.634 125.181 111.163 1.00 60.18  ? 176 ALA A CA  1 
ATOM 1355 C C   . ALA A 1 176 ? 106.728 125.318 112.212 1.00 61.53  ? 176 ALA A C   1 
ATOM 1356 O O   . ALA A 1 176 ? 107.683 124.534 112.192 1.00 66.78  ? 176 ALA A O   1 
ATOM 1357 C CB  . ALA A 1 176 ? 106.266 125.141 109.769 1.00 62.30  ? 176 ALA A CB  1 
ATOM 1358 N N   . ILE A 1 177 ? 106.619 126.283 113.121 1.00 56.35  ? 177 ILE A N   1 
ATOM 1359 C CA  . ILE A 1 177 ? 107.657 126.522 114.114 1.00 55.91  ? 177 ILE A CA  1 
ATOM 1360 C C   . ILE A 1 177 ? 107.139 126.468 115.547 1.00 56.18  ? 177 ILE A C   1 
ATOM 1361 O O   . ILE A 1 177 ? 107.953 126.311 116.472 1.00 48.50  ? 177 ILE A O   1 
ATOM 1362 C CB  . ILE A 1 177 ? 108.366 127.871 113.847 1.00 54.82  ? 177 ILE A CB  1 
ATOM 1363 C CG1 . ILE A 1 177 ? 109.789 127.881 114.417 1.00 56.59  ? 177 ILE A CG1 1 
ATOM 1364 C CG2 . ILE A 1 177 ? 107.544 129.043 114.374 1.00 59.82  ? 177 ILE A CG2 1 
ATOM 1365 C CD1 . ILE A 1 177 ? 110.542 129.163 114.154 1.00 55.05  ? 177 ILE A CD1 1 
ATOM 1366 N N   . ARG A 1 178 ? 105.823 126.542 115.760 1.00 56.93  ? 178 ARG A N   1 
ATOM 1367 C CA  . ARG A 1 178 ? 105.246 126.667 117.099 1.00 53.18  ? 178 ARG A CA  1 
ATOM 1368 C C   . ARG A 1 178 ? 105.635 125.580 118.101 1.00 58.04  ? 178 ARG A C   1 
ATOM 1369 O O   . ARG A 1 178 ? 105.852 125.948 119.274 1.00 57.53  ? 178 ARG A O   1 
ATOM 1370 C CB  . ARG A 1 178 ? 103.716 126.758 116.983 1.00 44.82  ? 178 ARG A CB  1 
ATOM 1371 C CG  . ARG A 1 178 ? 103.228 127.616 115.826 1.00 46.10  ? 178 ARG A CG  1 
ATOM 1372 C CD  . ARG A 1 178 ? 101.724 127.476 115.618 1.00 58.19  ? 178 ARG A CD  1 
ATOM 1373 N NE  . ARG A 1 178 ? 100.963 128.506 116.315 1.00 63.69  ? 178 ARG A NE  1 
ATOM 1374 C CZ  . ARG A 1 178 ? 99.857  128.278 117.011 1.00 59.87  ? 178 ARG A CZ  1 
ATOM 1375 N NH1 . ARG A 1 178 ? 99.350  127.062 117.126 1.00 59.71  ? 178 ARG A NH1 1 
ATOM 1376 N NH2 . ARG A 1 178 ? 99.240  129.298 117.601 1.00 53.09  ? 178 ARG A NH2 1 
ATOM 1377 N N   . PRO A 1 179 ? 105.703 124.273 117.770 1.00 61.09  ? 179 PRO A N   1 
ATOM 1378 C CA  . PRO A 1 179 ? 106.130 123.282 118.779 1.00 53.06  ? 179 PRO A CA  1 
ATOM 1379 C C   . PRO A 1 179 ? 107.506 123.542 119.373 1.00 59.28  ? 179 PRO A C   1 
ATOM 1380 O O   . PRO A 1 179 ? 107.712 123.273 120.566 1.00 61.53  ? 179 PRO A O   1 
ATOM 1381 C CB  . PRO A 1 179 ? 106.078 121.955 118.029 1.00 53.93  ? 179 PRO A CB  1 
ATOM 1382 C CG  . PRO A 1 179 ? 106.082 122.325 116.597 1.00 56.41  ? 179 PRO A CG  1 
ATOM 1383 C CD  . PRO A 1 179 ? 105.277 123.566 116.548 1.00 61.43  ? 179 PRO A CD  1 
ATOM 1384 N N   . PHE A 1 180 ? 108.435 124.077 118.582 1.00 64.46  ? 180 PHE A N   1 
ATOM 1385 C CA  . PHE A 1 180 ? 109.740 124.436 119.123 1.00 59.80  ? 180 PHE A CA  1 
ATOM 1386 C C   . PHE A 1 180 ? 109.625 125.571 120.131 1.00 61.23  ? 180 PHE A C   1 
ATOM 1387 O O   . PHE A 1 180 ? 110.300 125.555 121.166 1.00 58.98  ? 180 PHE A O   1 
ATOM 1388 C CB  . PHE A 1 180 ? 110.702 124.802 117.995 1.00 58.77  ? 180 PHE A CB  1 
ATOM 1389 C CG  . PHE A 1 180 ? 112.076 125.171 118.473 1.00 55.76  ? 180 PHE A CG  1 
ATOM 1390 C CD1 . PHE A 1 180 ? 112.452 126.498 118.612 1.00 54.07  ? 180 PHE A CD1 1 
ATOM 1391 C CD2 . PHE A 1 180 ? 112.976 124.184 118.835 1.00 56.56  ? 180 PHE A CD2 1 
ATOM 1392 C CE1 . PHE A 1 180 ? 113.711 126.830 119.065 1.00 48.16  ? 180 PHE A CE1 1 
ATOM 1393 C CE2 . PHE A 1 180 ? 114.238 124.510 119.287 1.00 57.74  ? 180 PHE A CE2 1 
ATOM 1394 C CZ  . PHE A 1 180 ? 114.605 125.836 119.402 1.00 56.95  ? 180 PHE A CZ  1 
ATOM 1395 N N   . LEU A 1 181 ? 108.776 126.562 119.850 1.00 57.32  ? 181 LEU A N   1 
ATOM 1396 C CA  . LEU A 1 181 ? 108.543 127.629 120.818 1.00 54.88  ? 181 LEU A CA  1 
ATOM 1397 C C   . LEU A 1 181 ? 107.910 127.092 122.096 1.00 53.72  ? 181 LEU A C   1 
ATOM 1398 O O   . LEU A 1 181 ? 108.276 127.520 123.199 1.00 54.46  ? 181 LEU A O   1 
ATOM 1399 C CB  . LEU A 1 181 ? 107.686 128.749 120.213 1.00 60.21  ? 181 LEU A CB  1 
ATOM 1400 C CG  . LEU A 1 181 ? 108.134 129.719 119.098 1.00 56.51  ? 181 LEU A CG  1 
ATOM 1401 C CD1 . LEU A 1 181 ? 108.779 129.114 117.862 1.00 50.89  ? 181 LEU A CD1 1 
ATOM 1402 C CD2 . LEU A 1 181 ? 106.944 130.573 118.677 1.00 57.30  ? 181 LEU A CD2 1 
ATOM 1403 N N   . GLN A 1 182 ? 106.981 126.135 121.976 1.00 56.75  ? 182 GLN A N   1 
ATOM 1404 C CA  . GLN A 1 182 ? 106.376 125.576 123.184 1.00 60.53  ? 182 GLN A CA  1 
ATOM 1405 C C   . GLN A 1 182 ? 107.388 124.785 124.013 1.00 65.58  ? 182 GLN A C   1 
ATOM 1406 O O   . GLN A 1 182 ? 107.406 124.906 125.243 1.00 66.66  ? 182 GLN A O   1 
ATOM 1407 C CB  . GLN A 1 182 ? 105.145 124.715 122.867 1.00 58.02  ? 182 GLN A CB  1 
ATOM 1408 C CG  . GLN A 1 182 ? 104.279 125.249 121.713 1.00 65.35  ? 182 GLN A CG  1 
ATOM 1409 C CD  . GLN A 1 182 ? 104.882 125.052 120.347 1.00 68.08  ? 182 GLN A CD  1 
ATOM 1410 O OE1 . GLN A 1 182 ? 105.848 124.324 120.194 1.00 60.58  ? 182 GLN A OE1 1 
ATOM 1411 N NE2 . GLN A 1 182 ? 104.336 125.742 119.348 1.00 70.04  ? 182 GLN A NE2 1 
ATOM 1412 N N   . THR A 1 183 ? 108.257 123.990 123.373 1.00 61.39  ? 183 THR A N   1 
ATOM 1413 C CA  . THR A 1 183 ? 109.206 123.231 124.191 1.00 56.73  ? 183 THR A CA  1 
ATOM 1414 C C   . THR A 1 183 ? 110.318 124.122 124.736 1.00 56.41  ? 183 THR A C   1 
ATOM 1415 O O   . THR A 1 183 ? 110.863 123.832 125.806 1.00 60.15  ? 183 THR A O   1 
ATOM 1416 C CB  . THR A 1 183 ? 109.824 122.053 123.434 1.00 62.45  ? 183 THR A CB  1 
ATOM 1417 O OG1 . THR A 1 183 ? 110.962 121.580 124.164 1.00 67.19  ? 183 THR A OG1 1 
ATOM 1418 C CG2 . THR A 1 183 ? 110.326 122.480 122.099 1.00 60.03  ? 183 THR A CG2 1 
ATOM 1419 N N   . ILE A 1 184 ? 110.657 125.213 124.039 1.00 49.18  ? 184 ILE A N   1 
ATOM 1420 C CA  . ILE A 1 184 ? 111.595 126.180 124.602 1.00 52.94  ? 184 ILE A CA  1 
ATOM 1421 C C   . ILE A 1 184 ? 110.985 126.860 125.821 1.00 55.72  ? 184 ILE A C   1 
ATOM 1422 O O   . ILE A 1 184 ? 111.664 127.066 126.836 1.00 53.70  ? 184 ILE A O   1 
ATOM 1423 C CB  . ILE A 1 184 ? 112.034 127.192 123.525 1.00 54.33  ? 184 ILE A CB  1 
ATOM 1424 C CG1 . ILE A 1 184 ? 113.051 126.541 122.580 1.00 53.42  ? 184 ILE A CG1 1 
ATOM 1425 C CG2 . ILE A 1 184 ? 112.570 128.488 124.141 1.00 52.14  ? 184 ILE A CG2 1 
ATOM 1426 C CD1 . ILE A 1 184 ? 114.506 126.725 122.976 1.00 54.21  ? 184 ILE A CD1 1 
ATOM 1427 N N   . SER A 1 185 ? 109.688 127.182 125.755 1.00 60.44  ? 185 SER A N   1 
ATOM 1428 C CA  . SER A 1 185 ? 108.997 127.731 126.919 1.00 62.16  ? 185 SER A CA  1 
ATOM 1429 C C   . SER A 1 185 ? 108.985 126.742 128.079 1.00 63.00  ? 185 SER A C   1 
ATOM 1430 O O   . SER A 1 185 ? 109.227 127.124 129.232 1.00 61.13  ? 185 SER A O   1 
ATOM 1431 C CB  . SER A 1 185 ? 107.571 128.127 126.544 1.00 60.48  ? 185 SER A CB  1 
ATOM 1432 O OG  . SER A 1 185 ? 107.133 129.228 127.317 1.00 54.24  ? 185 SER A OG  1 
ATOM 1433 N N   . ILE A 1 186 ? 108.725 125.464 127.786 1.00 66.85  ? 186 ILE A N   1 
ATOM 1434 C CA  . ILE A 1 186 ? 108.705 124.435 128.826 1.00 66.24  ? 186 ILE A CA  1 
ATOM 1435 C C   . ILE A 1 186 ? 110.083 124.280 129.459 1.00 66.33  ? 186 ILE A C   1 
ATOM 1436 O O   . ILE A 1 186 ? 110.214 124.213 130.688 1.00 65.87  ? 186 ILE A O   1 
ATOM 1437 C CB  . ILE A 1 186 ? 108.186 123.105 128.247 1.00 61.13  ? 186 ILE A CB  1 
ATOM 1438 C CG1 . ILE A 1 186 ? 106.694 123.215 127.932 1.00 60.47  ? 186 ILE A CG1 1 
ATOM 1439 C CG2 . ILE A 1 186 ? 108.430 121.960 129.215 1.00 65.64  ? 186 ILE A CG2 1 
ATOM 1440 C CD1 . ILE A 1 186 ? 106.222 122.268 126.857 1.00 64.52  ? 186 ILE A CD1 1 
ATOM 1441 N N   . GLY A 1 187 ? 111.133 124.261 128.634 1.00 62.33  ? 187 GLY A N   1 
ATOM 1442 C CA  . GLY A 1 187 ? 112.483 124.146 129.161 1.00 62.26  ? 187 GLY A CA  1 
ATOM 1443 C C   . GLY A 1 187 ? 112.900 125.342 129.997 1.00 60.89  ? 187 GLY A C   1 
ATOM 1444 O O   . GLY A 1 187 ? 113.530 125.184 131.045 1.00 57.12  ? 187 GLY A O   1 
ATOM 1445 N N   . LEU A 1 188 ? 112.542 126.552 129.556 1.00 61.53  ? 188 LEU A N   1 
ATOM 1446 C CA  . LEU A 1 188 ? 112.937 127.745 130.297 1.00 66.68  ? 188 LEU A CA  1 
ATOM 1447 C C   . LEU A 1 188 ? 112.190 127.855 131.622 1.00 65.31  ? 188 LEU A C   1 
ATOM 1448 O O   . LEU A 1 188 ? 112.781 128.241 132.639 1.00 69.74  ? 188 LEU A O   1 
ATOM 1449 C CB  . LEU A 1 188 ? 112.748 128.993 129.429 1.00 61.80  ? 188 LEU A CB  1 
ATOM 1450 C CG  . LEU A 1 188 ? 111.421 129.587 128.964 1.00 63.36  ? 188 LEU A CG  1 
ATOM 1451 C CD1 . LEU A 1 188 ? 110.811 130.511 129.991 1.00 67.15  ? 188 LEU A CD1 1 
ATOM 1452 C CD2 . LEU A 1 188 ? 111.642 130.328 127.652 1.00 63.65  ? 188 LEU A CD2 1 
ATOM 1453 N N   . VAL A 1 189 ? 110.900 127.501 131.640 1.00 65.17  ? 189 VAL A N   1 
ATOM 1454 C CA  . VAL A 1 189 ? 110.175 127.431 132.908 1.00 65.71  ? 189 VAL A CA  1 
ATOM 1455 C C   . VAL A 1 189 ? 110.757 126.340 133.801 1.00 65.12  ? 189 VAL A C   1 
ATOM 1456 O O   . VAL A 1 189 ? 110.827 126.502 135.028 1.00 66.56  ? 189 VAL A O   1 
ATOM 1457 C CB  . VAL A 1 189 ? 108.667 127.231 132.649 1.00 65.18  ? 189 VAL A CB  1 
ATOM 1458 C CG1 . VAL A 1 189 ? 107.911 127.026 133.946 1.00 69.59  ? 189 VAL A CG1 1 
ATOM 1459 C CG2 . VAL A 1 189 ? 108.097 128.440 131.938 1.00 66.44  ? 189 VAL A CG2 1 
ATOM 1460 N N   . SER A 1 190 ? 111.210 125.232 133.207 1.00 68.83  ? 190 SER A N   1 
ATOM 1461 C CA  . SER A 1 190 ? 111.828 124.162 133.983 1.00 73.62  ? 190 SER A CA  1 
ATOM 1462 C C   . SER A 1 190 ? 113.111 124.634 134.660 1.00 75.51  ? 190 SER A C   1 
ATOM 1463 O O   . SER A 1 190 ? 113.323 124.377 135.852 1.00 74.25  ? 190 SER A O   1 
ATOM 1464 C CB  . SER A 1 190 ? 112.102 122.962 133.079 1.00 76.68  ? 190 SER A CB  1 
ATOM 1465 O OG  . SER A 1 190 ? 110.968 122.659 132.283 1.00 73.66  ? 190 SER A OG  1 
ATOM 1466 N N   . PHE A 1 191 ? 113.973 125.343 133.919 1.00 76.13  ? 191 PHE A N   1 
ATOM 1467 C CA  . PHE A 1 191 ? 115.187 125.873 134.540 1.00 76.94  ? 191 PHE A CA  1 
ATOM 1468 C C   . PHE A 1 191 ? 114.865 126.942 135.576 1.00 77.41  ? 191 PHE A C   1 
ATOM 1469 O O   . PHE A 1 191 ? 115.526 127.000 136.622 1.00 80.05  ? 191 PHE A O   1 
ATOM 1470 C CB  . PHE A 1 191 ? 116.173 126.441 133.510 1.00 79.76  ? 191 PHE A CB  1 
ATOM 1471 C CG  . PHE A 1 191 ? 116.351 125.599 132.276 1.00 81.96  ? 191 PHE A CG  1 
ATOM 1472 C CD1 . PHE A 1 191 ? 116.548 124.230 132.367 1.00 85.62  ? 191 PHE A CD1 1 
ATOM 1473 C CD2 . PHE A 1 191 ? 116.420 126.196 131.028 1.00 77.22  ? 191 PHE A CD2 1 
ATOM 1474 C CE1 . PHE A 1 191 ? 116.732 123.464 131.228 1.00 85.12  ? 191 PHE A CE1 1 
ATOM 1475 C CE2 . PHE A 1 191 ? 116.605 125.440 129.887 1.00 80.18  ? 191 PHE A CE2 1 
ATOM 1476 C CZ  . PHE A 1 191 ? 116.765 124.072 129.987 1.00 85.02  ? 191 PHE A CZ  1 
ATOM 1477 N N   . GLY A 1 192 ? 113.845 127.769 135.320 1.00 75.78  ? 192 GLY A N   1 
ATOM 1478 C CA  . GLY A 1 192 ? 113.458 128.779 136.293 1.00 78.06  ? 192 GLY A CA  1 
ATOM 1479 C C   . GLY A 1 192 ? 112.982 128.178 137.603 1.00 79.13  ? 192 GLY A C   1 
ATOM 1480 O O   . GLY A 1 192 ? 113.387 128.615 138.681 1.00 80.06  ? 192 GLY A O   1 
ATOM 1481 N N   . GLU A 1 193 ? 112.140 127.143 137.522 1.00 83.76  ? 193 GLU A N   1 
ATOM 1482 C CA  . GLU A 1 193 ? 111.666 126.464 138.727 1.00 80.80  ? 193 GLU A CA  1 
ATOM 1483 C C   . GLU A 1 193 ? 112.791 125.720 139.439 1.00 81.00  ? 193 GLU A C   1 
ATOM 1484 O O   . GLU A 1 193 ? 112.888 125.769 140.674 1.00 83.69  ? 193 GLU A O   1 
ATOM 1485 C CB  . GLU A 1 193 ? 110.534 125.500 138.375 1.00 83.95  ? 193 GLU A CB  1 
ATOM 1486 C CG  . GLU A 1 193 ? 109.983 124.721 139.565 1.00 84.26  ? 193 GLU A CG  1 
ATOM 1487 C CD  . GLU A 1 193 ? 109.317 125.608 140.600 1.00 83.35  ? 193 GLU A CD  1 
ATOM 1488 O OE1 . GLU A 1 193 ? 108.117 125.911 140.435 1.00 84.93  ? 193 GLU A OE1 1 
ATOM 1489 O OE2 . GLU A 1 193 ? 109.989 125.996 141.580 1.00 83.44  ? 193 GLU A OE2 1 
ATOM 1490 N N   . HIS A 1 194 ? 113.656 125.038 138.677 1.00 85.50  ? 194 HIS A N   1 
ATOM 1491 C CA  . HIS A 1 194 ? 114.759 124.283 139.267 1.00 85.23  ? 194 HIS A CA  1 
ATOM 1492 C C   . HIS A 1 194 ? 115.725 125.189 140.009 1.00 85.84  ? 194 HIS A C   1 
ATOM 1493 O O   . HIS A 1 194 ? 116.258 124.815 141.061 1.00 85.97  ? 194 HIS A O   1 
ATOM 1494 C CB  . HIS A 1 194 ? 115.513 123.519 138.183 1.00 82.78  ? 194 HIS A CB  1 
ATOM 1495 C CG  . HIS A 1 194 ? 114.843 122.255 137.760 1.00 90.20  ? 194 HIS A CG  1 
ATOM 1496 N ND1 . HIS A 1 194 ? 113.900 122.210 136.756 1.00 85.49  ? 194 HIS A ND1 1 
ATOM 1497 C CD2 . HIS A 1 194 ? 114.971 120.987 138.215 1.00 85.86  ? 194 HIS A CD2 1 
ATOM 1498 C CE1 . HIS A 1 194 ? 113.481 120.967 136.607 1.00 86.30  ? 194 HIS A CE1 1 
ATOM 1499 N NE2 . HIS A 1 194 ? 114.115 120.205 137.480 1.00 89.28  ? 194 HIS A NE2 1 
ATOM 1500 N N   . TYR A 1 195 ? 115.977 126.371 139.463 1.00 89.56  ? 195 TYR A N   1 
ATOM 1501 C CA  . TYR A 1 195 ? 116.920 127.287 140.078 1.00 89.57  ? 195 TYR A CA  1 
ATOM 1502 C C   . TYR A 1 195 ? 116.285 128.159 141.154 1.00 87.29  ? 195 TYR A C   1 
ATOM 1503 O O   . TYR A 1 195 ? 116.997 128.651 142.037 1.00 87.30  ? 195 TYR A O   1 
ATOM 1504 C CB  . TYR A 1 195 ? 117.539 128.142 138.994 1.00 85.62  ? 195 TYR A CB  1 
ATOM 1505 C CG  . TYR A 1 195 ? 118.906 127.693 138.524 1.00 89.23  ? 195 TYR A CG  1 
ATOM 1506 C CD1 . TYR A 1 195 ? 119.140 127.411 137.183 1.00 89.27  ? 195 TYR A CD1 1 
ATOM 1507 C CD2 . TYR A 1 195 ? 119.980 127.630 139.402 1.00 88.31  ? 195 TYR A CD2 1 
ATOM 1508 C CE1 . TYR A 1 195 ? 120.394 127.030 136.739 1.00 89.61  ? 195 TYR A CE1 1 
ATOM 1509 C CE2 . TYR A 1 195 ? 121.240 127.251 138.968 1.00 87.34  ? 195 TYR A CE2 1 
ATOM 1510 C CZ  . TYR A 1 195 ? 121.441 126.952 137.636 1.00 87.32  ? 195 TYR A CZ  1 
ATOM 1511 O OH  . TYR A 1 195 ? 122.691 126.570 137.199 1.00 86.47  ? 195 TYR A OH  1 
ATOM 1512 N N   . LYS A 1 196 ? 114.970 128.387 141.090 1.00 90.14  ? 196 LYS A N   1 
ATOM 1513 C CA  . LYS A 1 196 ? 114.279 128.965 142.236 1.00 90.45  ? 196 LYS A CA  1 
ATOM 1514 C C   . LYS A 1 196 ? 114.317 128.007 143.417 1.00 90.01  ? 196 LYS A C   1 
ATOM 1515 O O   . LYS A 1 196 ? 114.511 128.427 144.564 1.00 90.22  ? 196 LYS A O   1 
ATOM 1516 C CB  . LYS A 1 196 ? 112.839 129.319 141.862 1.00 92.39  ? 196 LYS A CB  1 
ATOM 1517 C CG  . LYS A 1 196 ? 111.993 129.819 143.023 1.00 92.75  ? 196 LYS A CG  1 
ATOM 1518 C CD  . LYS A 1 196 ? 112.531 131.123 143.586 1.00 94.16  ? 196 LYS A CD  1 
ATOM 1519 C CE  . LYS A 1 196 ? 111.879 131.455 144.919 1.00 92.35  ? 196 LYS A CE  1 
ATOM 1520 N NZ  . LYS A 1 196 ? 112.431 130.626 146.028 1.00 94.02  ? 196 LYS A NZ  1 
ATOM 1521 N N   . ARG A 1 197 ? 114.160 126.710 143.150 1.00 87.11  ? 197 ARG A N   1 
ATOM 1522 C CA  . ARG A 1 197 ? 114.328 125.700 144.183 1.00 86.52  ? 197 ARG A CA  1 
ATOM 1523 C C   . ARG A 1 197 ? 115.791 125.375 144.461 1.00 86.89  ? 197 ARG A C   1 
ATOM 1524 O O   . ARG A 1 197 ? 116.068 124.671 145.439 1.00 86.91  ? 197 ARG A O   1 
ATOM 1525 C CB  . ARG A 1 197 ? 113.578 124.425 143.792 1.00 86.96  ? 197 ARG A CB  1 
ATOM 1526 C CG  . ARG A 1 197 ? 112.066 124.569 143.851 1.00 86.94  ? 197 ARG A CG  1 
ATOM 1527 C CD  . ARG A 1 197 ? 111.379 123.222 143.976 1.00 84.85  ? 197 ARG A CD  1 
ATOM 1528 N NE  . ARG A 1 197 ? 110.161 123.318 144.772 1.00 87.34  ? 197 ARG A NE  1 
ATOM 1529 C CZ  . ARG A 1 197 ? 109.598 122.299 145.407 1.00 89.67  ? 197 ARG A CZ  1 
ATOM 1530 N NH1 . ARG A 1 197 ? 110.115 121.082 145.354 1.00 90.75  ? 197 ARG A NH1 1 
ATOM 1531 N NH2 . ARG A 1 197 ? 108.491 122.506 146.113 1.00 87.47  ? 197 ARG A NH2 1 
ATOM 1532 N N   . ASN A 1 198 ? 116.713 125.872 143.631 1.00 85.71  ? 198 ASN A N   1 
ATOM 1533 C CA  . ASN A 1 198 ? 118.163 125.681 143.771 1.00 84.06  ? 198 ASN A CA  1 
ATOM 1534 C C   . ASN A 1 198 ? 118.572 124.210 143.848 1.00 84.40  ? 198 ASN A C   1 
ATOM 1535 O O   . ASN A 1 198 ? 119.680 123.842 143.455 1.00 86.14  ? 198 ASN A O   1 
ATOM 1536 C CB  . ASN A 1 198 ? 118.692 126.432 144.999 1.00 83.36  ? 198 ASN A CB  1 
ATOM 1537 C CG  . ASN A 1 198 ? 118.904 127.910 144.732 1.00 83.38  ? 198 ASN A CG  1 
ATOM 1538 O OD1 . ASN A 1 198 ? 117.967 128.706 144.799 1.00 84.50  ? 198 ASN A OD1 1 
ATOM 1539 N ND2 . ASN A 1 198 ? 120.141 128.285 144.426 0.96 84.06  ? 198 ASN A ND2 1 
ATOM 1540 N N   . ARG A 1 214 ? 104.199 117.852 133.740 1.00 80.13  ? 214 ARG A N   1 
ATOM 1541 C CA  . ARG A 1 214 ? 103.612 118.588 134.853 1.00 84.51  ? 214 ARG A CA  1 
ATOM 1542 C C   . ARG A 1 214 ? 102.690 119.688 134.345 1.00 84.85  ? 214 ARG A C   1 
ATOM 1543 O O   . ARG A 1 214 ? 101.486 119.484 134.187 1.00 88.06  ? 214 ARG A O   1 
ATOM 1544 C CB  . ARG A 1 214 ? 104.706 119.187 135.737 1.00 85.92  ? 214 ARG A CB  1 
ATOM 1545 C CG  . ARG A 1 214 ? 105.962 118.338 135.828 0.56 84.12  ? 214 ARG A CG  1 
ATOM 1546 C CD  . ARG A 1 214 ? 107.218 119.199 135.771 1.00 83.77  ? 214 ARG A CD  1 
ATOM 1547 N NE  . ARG A 1 214 ? 107.412 119.820 134.465 1.00 82.52  ? 214 ARG A NE  1 
ATOM 1548 C CZ  . ARG A 1 214 ? 107.875 119.193 133.391 1.00 84.86  ? 214 ARG A CZ  1 
ATOM 1549 N NH1 . ARG A 1 214 ? 108.228 117.919 133.431 1.00 83.93  ? 214 ARG A NH1 1 
ATOM 1550 N NH2 . ARG A 1 214 ? 107.994 119.865 132.250 1.00 85.77  ? 214 ARG A NH2 1 
ATOM 1551 N N   . PHE A 1 215 ? 103.268 120.859 134.095 1.00 77.07  ? 215 PHE A N   1 
ATOM 1552 C CA  . PHE A 1 215 ? 102.542 122.005 133.567 1.00 77.49  ? 215 PHE A CA  1 
ATOM 1553 C C   . PHE A 1 215 ? 102.479 122.020 132.045 1.00 77.52  ? 215 PHE A C   1 
ATOM 1554 O O   . PHE A 1 215 ? 101.800 122.879 131.476 1.00 79.48  ? 215 PHE A O   1 
ATOM 1555 C CB  . PHE A 1 215 ? 103.185 123.303 134.065 1.00 77.79  ? 215 PHE A CB  1 
ATOM 1556 C CG  . PHE A 1 215 ? 104.320 123.778 133.206 1.00 76.80  ? 215 PHE A CG  1 
ATOM 1557 C CD1 . PHE A 1 215 ? 104.214 124.954 132.485 1.00 77.35  ? 215 PHE A CD1 1 
ATOM 1558 C CD2 . PHE A 1 215 ? 105.494 123.046 133.119 1.00 74.16  ? 215 PHE A CD2 1 
ATOM 1559 C CE1 . PHE A 1 215 ? 105.254 125.389 131.694 1.00 78.94  ? 215 PHE A CE1 1 
ATOM 1560 C CE2 . PHE A 1 215 ? 106.534 123.475 132.328 1.00 76.83  ? 215 PHE A CE2 1 
ATOM 1561 C CZ  . PHE A 1 215 ? 106.413 124.648 131.614 1.00 76.36  ? 215 PHE A CZ  1 
ATOM 1562 N N   . ALA A 1 216 ? 103.178 121.104 131.377 1.00 79.68  ? 216 ALA A N   1 
ATOM 1563 C CA  . ALA A 1 216 ? 103.209 121.070 129.922 1.00 79.67  ? 216 ALA A CA  1 
ATOM 1564 C C   . ALA A 1 216 ? 101.921 120.547 129.308 1.00 82.23  ? 216 ALA A C   1 
ATOM 1565 O O   . ALA A 1 216 ? 101.636 120.854 128.145 1.00 80.71  ? 216 ALA A O   1 
ATOM 1566 C CB  . ALA A 1 216 ? 104.383 120.213 129.441 1.00 79.41  ? 216 ALA A CB  1 
ATOM 1567 N N   . ILE A 1 217 ? 101.146 119.759 130.054 1.00 81.12  ? 217 ILE A N   1 
ATOM 1568 C CA  . ILE A 1 217 ? 99.888  119.235 129.532 1.00 80.16  ? 217 ILE A CA  1 
ATOM 1569 C C   . ILE A 1 217 ? 98.846  120.342 129.396 1.00 80.57  ? 217 ILE A C   1 
ATOM 1570 O O   . ILE A 1 217 ? 98.144  120.416 128.380 1.00 83.46  ? 217 ILE A O   1 
ATOM 1571 C CB  . ILE A 1 217 ? 99.394  118.084 130.428 1.00 78.78  ? 217 ILE A CB  1 
ATOM 1572 C CG1 . ILE A 1 217 ? 100.297 116.860 130.258 1.00 79.43  ? 217 ILE A CG1 1 
ATOM 1573 C CG2 . ILE A 1 217 ? 97.951  117.714 130.114 1.00 76.63  ? 217 ILE A CG2 1 
ATOM 1574 C CD1 . ILE A 1 217 ? 101.025 116.455 131.519 1.00 82.55  ? 217 ILE A CD1 1 
ATOM 1575 N N   . ASP A 1 218 ? 98.748  121.234 130.382 1.00 79.79  ? 218 ASP A N   1 
ATOM 1576 C CA  . ASP A 1 218 ? 97.750  122.300 130.372 1.00 79.22  ? 218 ASP A CA  1 
ATOM 1577 C C   . ASP A 1 218 ? 98.379  123.623 129.950 1.00 78.16  ? 218 ASP A C   1 
ATOM 1578 O O   . ASP A 1 218 ? 99.164  124.210 130.711 1.00 78.12  ? 218 ASP A O   1 
ATOM 1579 C CB  . ASP A 1 218 ? 97.092  122.431 131.751 1.00 78.33  ? 218 ASP A CB  1 
ATOM 1580 C CG  . ASP A 1 218 ? 98.092  122.335 132.895 1.00 78.34  ? 218 ASP A CG  1 
ATOM 1581 O OD1 . ASP A 1 218 ? 99.280  122.055 132.632 1.00 77.57  ? 218 ASP A OD1 1 
ATOM 1582 O OD2 . ASP A 1 218 ? 97.688  122.542 134.059 1.00 79.03  ? 218 ASP A OD2 1 
ATOM 1583 N N   . PRO A 1 219 ? 98.071  124.139 128.756 1.00 70.08  ? 219 PRO A N   1 
ATOM 1584 C CA  . PRO A 1 219 ? 98.636  125.433 128.343 1.00 70.47  ? 219 PRO A CA  1 
ATOM 1585 C C   . PRO A 1 219 ? 98.025  126.627 129.057 1.00 69.62  ? 219 PRO A C   1 
ATOM 1586 O O   . PRO A 1 219 ? 98.542  127.741 128.902 1.00 71.54  ? 219 PRO A O   1 
ATOM 1587 C CB  . PRO A 1 219 ? 98.340  125.484 126.836 1.00 72.99  ? 219 PRO A CB  1 
ATOM 1588 C CG  . PRO A 1 219 ? 97.974  124.078 126.452 1.00 76.76  ? 219 PRO A CG  1 
ATOM 1589 C CD  . PRO A 1 219 ? 97.321  123.502 127.664 1.00 73.50  ? 219 PRO A CD  1 
ATOM 1590 N N   . GLU A 1 220 ? 96.942  126.435 129.816 1.00 84.99  ? 220 GLU A N   1 
ATOM 1591 C CA  . GLU A 1 220 ? 96.317  127.546 130.526 1.00 88.85  ? 220 GLU A CA  1 
ATOM 1592 C C   . GLU A 1 220 ? 97.226  128.084 131.624 1.00 87.10  ? 220 GLU A C   1 
ATOM 1593 O O   . GLU A 1 220 ? 97.230  129.289 131.899 1.00 89.10  ? 220 GLU A O   1 
ATOM 1594 C CB  . GLU A 1 220 ? 94.978  127.105 131.116 1.00 91.42  ? 220 GLU A CB  1 
ATOM 1595 C CG  . GLU A 1 220 ? 93.973  126.560 130.106 1.00 90.45  ? 220 GLU A CG  1 
ATOM 1596 C CD  . GLU A 1 220 ? 93.936  127.352 128.814 1.00 89.67  ? 220 GLU A CD  1 
ATOM 1597 O OE1 . GLU A 1 220 ? 93.286  128.417 128.791 1.00 88.72  ? 220 GLU A OE1 1 
ATOM 1598 O OE2 . GLU A 1 220 ? 94.539  126.901 127.817 1.00 88.07  ? 220 GLU A OE2 1 
ATOM 1599 N N   . LEU A 1 221 ? 97.997  127.209 132.263 1.00 74.90  ? 221 LEU A N   1 
ATOM 1600 C CA  . LEU A 1 221 ? 98.898  127.612 133.331 1.00 77.27  ? 221 LEU A CA  1 
ATOM 1601 C C   . LEU A 1 221 ? 100.296 127.950 132.836 1.00 79.23  ? 221 LEU A C   1 
ATOM 1602 O O   . LEU A 1 221 ? 101.173 128.226 133.660 1.00 83.01  ? 221 LEU A O   1 
ATOM 1603 C CB  . LEU A 1 221 ? 98.984  126.514 134.395 1.00 78.88  ? 221 LEU A CB  1 
ATOM 1604 C CG  . LEU A 1 221 ? 97.969  126.592 135.538 1.00 78.06  ? 221 LEU A CG  1 
ATOM 1605 C CD1 . LEU A 1 221 ? 98.341  125.621 136.650 1.00 78.03  ? 221 LEU A CD1 1 
ATOM 1606 C CD2 . LEU A 1 221 ? 97.860  128.012 136.077 1.00 78.04  ? 221 LEU A CD2 1 
ATOM 1607 N N   . ARG A 1 222 ? 100.532 127.912 131.523 1.00 70.49  ? 222 ARG A N   1 
ATOM 1608 C CA  . ARG A 1 222 ? 101.832 128.310 130.987 1.00 71.01  ? 222 ARG A CA  1 
ATOM 1609 C C   . ARG A 1 222 ? 102.093 129.796 131.207 1.00 68.87  ? 222 ARG A C   1 
ATOM 1610 O O   . ARG A 1 222 ? 103.204 130.191 131.590 1.00 67.47  ? 222 ARG A O   1 
ATOM 1611 C CB  . ARG A 1 222 ? 101.903 127.966 129.502 1.00 66.93  ? 222 ARG A CB  1 
ATOM 1612 C CG  . ARG A 1 222 ? 102.147 126.500 129.237 1.00 71.51  ? 222 ARG A CG  1 
ATOM 1613 C CD  . ARG A 1 222 ? 103.521 126.285 128.638 1.00 68.11  ? 222 ARG A CD  1 
ATOM 1614 N NE  . ARG A 1 222 ? 103.747 127.126 127.469 1.00 62.18  ? 222 ARG A NE  1 
ATOM 1615 C CZ  . ARG A 1 222 ? 103.195 126.932 126.279 1.00 64.08  ? 222 ARG A CZ  1 
ATOM 1616 N NH1 . ARG A 1 222 ? 102.413 125.893 126.036 1.00 68.69  ? 222 ARG A NH1 1 
ATOM 1617 N NH2 . ARG A 1 222 ? 103.447 127.794 125.300 1.00 68.45  ? 222 ARG A NH2 1 
ATOM 1618 N N   . GLY A 1 223 ? 101.073 130.628 130.981 1.00 63.53  ? 223 GLY A N   1 
ATOM 1619 C CA  . GLY A 1 223 ? 101.225 132.059 131.163 1.00 66.29  ? 223 GLY A CA  1 
ATOM 1620 C C   . GLY A 1 223 ? 101.503 132.458 132.598 1.00 67.60  ? 223 GLY A C   1 
ATOM 1621 O O   . GLY A 1 223 ? 102.256 133.404 132.845 1.00 70.70  ? 223 GLY A O   1 
ATOM 1622 N N   . ALA A 1 224 ? 100.962 131.703 133.560 1.00 67.90  ? 224 ALA A N   1 
ATOM 1623 C CA  . ALA A 1 224 ? 101.110 132.011 134.980 1.00 70.45  ? 224 ALA A CA  1 
ATOM 1624 C C   . ALA A 1 224 ? 102.549 131.919 135.473 1.00 66.03  ? 224 ALA A C   1 
ATOM 1625 O O   . ALA A 1 224 ? 102.812 132.289 136.621 1.00 66.27  ? 224 ALA A O   1 
ATOM 1626 C CB  . ALA A 1 224 ? 100.227 131.080 135.813 1.00 70.96  ? 224 ALA A CB  1 
ATOM 1627 N N   . GLU A 1 225 ? 103.473 131.414 134.658 1.00 62.56  ? 225 GLU A N   1 
ATOM 1628 C CA  . GLU A 1 225 ? 104.892 131.536 134.957 1.00 68.47  ? 225 GLU A CA  1 
ATOM 1629 C C   . GLU A 1 225 ? 105.633 132.268 133.842 1.00 68.10  ? 225 GLU A C   1 
ATOM 1630 O O   . GLU A 1 225 ? 106.650 132.925 134.102 1.00 68.27  ? 225 GLU A O   1 
ATOM 1631 C CB  . GLU A 1 225 ? 105.511 130.161 135.202 1.00 69.37  ? 225 GLU A CB  1 
ATOM 1632 C CG  . GLU A 1 225 ? 104.932 129.051 134.351 1.00 70.03  ? 225 GLU A CG  1 
ATOM 1633 C CD  . GLU A 1 225 ? 103.896 128.237 135.099 1.00 73.37  ? 225 GLU A CD  1 
ATOM 1634 O OE1 . GLU A 1 225 ? 103.088 128.836 135.840 1.00 68.43  ? 225 GLU A OE1 1 
ATOM 1635 O OE2 . GLU A 1 225 ? 103.898 126.996 134.957 1.00 68.71  ? 225 GLU A OE2 1 
ATOM 1636 N N   . PHE A 1 226 ? 105.133 132.184 132.603 1.00 67.76  ? 226 PHE A N   1 
ATOM 1637 C CA  . PHE A 1 226 ? 105.818 132.847 131.498 1.00 64.13  ? 226 PHE A CA  1 
ATOM 1638 C C   . PHE A 1 226 ? 105.697 134.365 131.555 1.00 57.37  ? 226 PHE A C   1 
ATOM 1639 O O   . PHE A 1 226 ? 106.493 135.060 130.917 1.00 56.53  ? 226 PHE A O   1 
ATOM 1640 C CB  . PHE A 1 226 ? 105.287 132.331 130.161 1.00 64.88  ? 226 PHE A CB  1 
ATOM 1641 C CG  . PHE A 1 226 ? 106.286 132.407 129.044 1.00 64.47  ? 226 PHE A CG  1 
ATOM 1642 C CD1 . PHE A 1 226 ? 107.626 132.622 129.307 1.00 64.94  ? 226 PHE A CD1 1 
ATOM 1643 C CD2 . PHE A 1 226 ? 105.886 132.256 127.729 1.00 64.06  ? 226 PHE A CD2 1 
ATOM 1644 C CE1 . PHE A 1 226 ? 108.541 132.696 128.285 1.00 69.11  ? 226 PHE A CE1 1 
ATOM 1645 C CE2 . PHE A 1 226 ? 106.800 132.328 126.704 1.00 63.16  ? 226 PHE A CE2 1 
ATOM 1646 C CZ  . PHE A 1 226 ? 108.127 132.544 126.986 1.00 63.77  ? 226 PHE A CZ  1 
ATOM 1647 N N   . GLU A 1 227 ? 104.728 134.899 132.295 1.00 62.31  ? 227 GLU A N   1 
ATOM 1648 C CA  . GLU A 1 227 ? 104.673 136.337 132.509 1.00 64.48  ? 227 GLU A CA  1 
ATOM 1649 C C   . GLU A 1 227 ? 105.330 136.763 133.811 1.00 68.64  ? 227 GLU A C   1 
ATOM 1650 O O   . GLU A 1 227 ? 105.694 137.936 133.950 1.00 68.82  ? 227 GLU A O   1 
ATOM 1651 C CB  . GLU A 1 227 ? 103.224 136.820 132.486 1.00 70.76  ? 227 GLU A CB  1 
ATOM 1652 C CG  . GLU A 1 227 ? 102.426 136.213 131.361 1.00 72.72  ? 227 GLU A CG  1 
ATOM 1653 C CD  . GLU A 1 227 ? 100.967 136.074 131.707 1.00 68.58  ? 227 GLU A CD  1 
ATOM 1654 O OE1 . GLU A 1 227 ? 100.466 136.863 132.535 1.00 64.71  ? 227 GLU A OE1 1 
ATOM 1655 O OE2 . GLU A 1 227 ? 100.332 135.141 131.181 1.00 68.21  ? 227 GLU A OE2 1 
ATOM 1656 N N   . ARG A 1 228 ? 105.483 135.846 134.767 1.00 72.43  ? 228 ARG A N   1 
ATOM 1657 C CA  . ARG A 1 228 ? 106.213 136.164 135.988 1.00 72.53  ? 228 ARG A CA  1 
ATOM 1658 C C   . ARG A 1 228 ? 107.718 136.168 135.760 1.00 75.74  ? 228 ARG A C   1 
ATOM 1659 O O   . ARG A 1 228 ? 108.434 136.961 136.388 1.00 72.67  ? 228 ARG A O   1 
ATOM 1660 C CB  . ARG A 1 228 ? 105.844 135.178 137.096 1.00 71.69  ? 228 ARG A CB  1 
ATOM 1661 C CG  . ARG A 1 228 ? 104.349 135.072 137.363 1.00 74.73  ? 228 ARG A CG  1 
ATOM 1662 C CD  . ARG A 1 228 ? 103.707 136.433 137.587 1.00 71.94  ? 228 ARG A CD  1 
ATOM 1663 N NE  . ARG A 1 228 ? 102.519 136.622 136.762 1.00 71.36  ? 228 ARG A NE  1 
ATOM 1664 C CZ  . ARG A 1 228 ? 101.285 136.322 137.143 1.00 72.32  ? 228 ARG A CZ  1 
ATOM 1665 N NH1 . ARG A 1 228 ? 101.036 135.800 138.333 1.00 72.64  ? 228 ARG A NH1 1 
ATOM 1666 N NH2 . ARG A 1 228 ? 100.274 136.550 136.309 1.00 71.97  ? 228 ARG A NH2 1 
ATOM 1667 N N   . ILE A 1 229 ? 108.218 135.310 134.863 1.00 69.46  ? 229 ILE A N   1 
ATOM 1668 C CA  . ILE A 1 229 ? 109.641 135.355 134.527 1.00 73.43  ? 229 ILE A CA  1 
ATOM 1669 C C   . ILE A 1 229 ? 110.021 136.588 133.722 1.00 70.35  ? 229 ILE A C   1 
ATOM 1670 O O   . ILE A 1 229 ? 111.214 136.879 133.588 1.00 62.80  ? 229 ILE A O   1 
ATOM 1671 C CB  . ILE A 1 229 ? 110.133 134.145 133.712 1.00 71.67  ? 229 ILE A CB  1 
ATOM 1672 C CG1 . ILE A 1 229 ? 109.468 134.127 132.340 1.00 69.03  ? 229 ILE A CG1 1 
ATOM 1673 C CG2 . ILE A 1 229 ? 109.886 132.849 134.467 1.00 69.43  ? 229 ILE A CG2 1 
ATOM 1674 C CD1 . ILE A 1 229 ? 110.438 133.889 131.223 1.00 66.73  ? 229 ILE A CD1 1 
ATOM 1675 N N   . THR A 1 230 ? 109.046 137.304 133.155 1.00 73.84  ? 230 THR A N   1 
ATOM 1676 C CA  . THR A 1 230 ? 109.350 138.556 132.472 1.00 72.75  ? 230 THR A CA  1 
ATOM 1677 C C   . THR A 1 230 ? 109.869 139.598 133.455 1.00 75.38  ? 230 THR A C   1 
ATOM 1678 O O   . THR A 1 230 ? 110.889 140.248 133.202 1.00 76.12  ? 230 THR A O   1 
ATOM 1679 C CB  . THR A 1 230 ? 108.104 139.063 131.737 1.00 77.20  ? 230 THR A CB  1 
ATOM 1680 O OG1 . THR A 1 230 ? 107.981 138.384 130.481 1.00 81.29  ? 230 THR A OG1 1 
ATOM 1681 C CG2 . THR A 1 230 ? 108.168 140.568 131.484 1.00 71.74  ? 230 THR A CG2 1 
ATOM 1682 N N   . GLN A 1 231 ? 109.211 139.735 134.602 1.00 82.68  ? 231 GLN A N   1 
ATOM 1683 C CA  . GLN A 1 231 ? 109.563 140.748 135.583 1.00 82.23  ? 231 GLN A CA  1 
ATOM 1684 C C   . GLN A 1 231 ? 110.332 140.189 136.772 1.00 78.98  ? 231 GLN A C   1 
ATOM 1685 O O   . GLN A 1 231 ? 110.655 140.947 137.691 1.00 79.23  ? 231 GLN A O   1 
ATOM 1686 C CB  . GLN A 1 231 ? 108.296 141.458 136.069 1.00 81.53  ? 231 GLN A CB  1 
ATOM 1687 C CG  . GLN A 1 231 ? 107.584 142.260 134.987 1.00 77.97  ? 231 GLN A CG  1 
ATOM 1688 C CD  . GLN A 1 231 ? 106.436 143.086 135.532 1.00 79.59  ? 231 GLN A CD  1 
ATOM 1689 O OE1 . GLN A 1 231 ? 106.452 144.316 135.466 1.00 78.28  ? 231 GLN A OE1 1 
ATOM 1690 N NE2 . GLN A 1 231 ? 105.432 142.412 136.081 1.00 78.69  ? 231 GLN A NE2 1 
ATOM 1691 N N   . ASN A 1 232 ? 110.633 138.892 136.784 1.00 71.18  ? 232 ASN A N   1 
ATOM 1692 C CA  . ASN A 1 232 ? 111.360 138.276 137.891 1.00 76.58  ? 232 ASN A CA  1 
ATOM 1693 C C   . ASN A 1 232 ? 112.569 137.500 137.380 1.00 79.11  ? 232 ASN A C   1 
ATOM 1694 O O   . ASN A 1 232 ? 112.790 136.339 137.730 1.00 82.00  ? 232 ASN A O   1 
ATOM 1695 C CB  . ASN A 1 232 ? 110.432 137.380 138.705 1.00 76.45  ? 232 ASN A CB  1 
ATOM 1696 C CG  . ASN A 1 232 ? 109.289 138.152 139.338 1.00 75.70  ? 232 ASN A CG  1 
ATOM 1697 O OD1 . ASN A 1 232 ? 109.501 139.180 139.982 1.00 76.21  ? 232 ASN A OD1 1 
ATOM 1698 N ND2 . ASN A 1 232 ? 108.069 137.663 139.152 1.00 77.33  ? 232 ASN A ND2 1 
ATOM 1699 N N   . LEU A 1 233 ? 113.378 138.139 136.535 1.00 78.84  ? 233 LEU A N   1 
ATOM 1700 C CA  . LEU A 1 233 ? 114.529 137.494 135.921 1.00 78.35  ? 233 LEU A CA  1 
ATOM 1701 C C   . LEU A 1 233 ? 115.777 138.345 136.120 1.00 75.86  ? 233 LEU A C   1 
ATOM 1702 O O   . LEU A 1 233 ? 115.700 139.571 136.238 1.00 73.74  ? 233 LEU A O   1 
ATOM 1703 C CB  . LEU A 1 233 ? 114.290 137.256 134.424 1.00 77.33  ? 233 LEU A CB  1 
ATOM 1704 C CG  . LEU A 1 233 ? 115.236 136.356 133.631 1.00 67.48  ? 233 LEU A CG  1 
ATOM 1705 C CD1 . LEU A 1 233 ? 114.418 135.332 132.878 1.00 68.49  ? 233 LEU A CD1 1 
ATOM 1706 C CD2 . LEU A 1 233 ? 116.099 137.167 132.678 1.00 65.37  ? 233 LEU A CD2 1 
ATOM 1707 N N   . ASP A 1 234 ? 116.928 137.677 136.164 1.00 76.52  ? 234 ASP A N   1 
ATOM 1708 C CA  . ASP A 1 234 ? 118.228 138.323 136.260 1.00 75.76  ? 234 ASP A CA  1 
ATOM 1709 C C   . ASP A 1 234 ? 119.069 137.957 135.042 1.00 74.11  ? 234 ASP A C   1 
ATOM 1710 O O   . ASP A 1 234 ? 118.923 136.869 134.478 1.00 75.17  ? 234 ASP A O   1 
ATOM 1711 C CB  . ASP A 1 234 ? 118.956 137.909 137.544 1.00 75.65  ? 234 ASP A CB  1 
ATOM 1712 C CG  . ASP A 1 234 ? 119.998 138.915 137.973 1.00 78.10  ? 234 ASP A CG  1 
ATOM 1713 O OD1 . ASP A 1 234 ? 119.614 140.016 138.419 1.00 77.39  ? 234 ASP A OD1 1 
ATOM 1714 O OD2 . ASP A 1 234 ? 121.203 138.605 137.867 1.00 78.41  ? 234 ASP A OD2 1 
ATOM 1715 N N   . VAL A 1 235 ? 119.946 138.879 134.632 1.00 74.05  ? 235 VAL A N   1 
ATOM 1716 C CA  . VAL A 1 235 ? 120.790 138.643 133.462 1.00 75.77  ? 235 VAL A CA  1 
ATOM 1717 C C   . VAL A 1 235 ? 121.841 137.571 133.731 1.00 71.74  ? 235 VAL A C   1 
ATOM 1718 O O   . VAL A 1 235 ? 122.251 136.860 132.803 1.00 68.54  ? 235 VAL A O   1 
ATOM 1719 C CB  . VAL A 1 235 ? 121.433 139.962 132.983 1.00 73.95  ? 235 VAL A CB  1 
ATOM 1720 C CG1 . VAL A 1 235 ? 122.500 140.458 133.954 1.00 71.77  ? 235 VAL A CG1 1 
ATOM 1721 C CG2 . VAL A 1 235 ? 121.997 139.813 131.571 1.00 69.28  ? 235 VAL A CG2 1 
ATOM 1722 N N   . HIS A 1 236 ? 122.253 137.400 134.993 1.00 73.66  ? 236 HIS A N   1 
ATOM 1723 C CA  . HIS A 1 236 ? 123.130 136.293 135.356 1.00 70.84  ? 236 HIS A CA  1 
ATOM 1724 C C   . HIS A 1 236 ? 122.446 134.956 135.131 1.00 73.07  ? 236 HIS A C   1 
ATOM 1725 O O   . HIS A 1 236 ? 123.115 133.927 134.987 1.00 75.65  ? 236 HIS A O   1 
ATOM 1726 C CB  . HIS A 1 236 ? 123.551 136.418 136.818 1.00 73.98  ? 236 HIS A CB  1 
ATOM 1727 C CG  . HIS A 1 236 ? 124.919 135.889 137.098 1.00 73.98  ? 236 HIS A CG  1 
ATOM 1728 N ND1 . HIS A 1 236 ? 126.055 136.461 136.569 1.00 73.92  ? 236 HIS A ND1 1 
ATOM 1729 C CD2 . HIS A 1 236 ? 125.339 134.848 137.855 1.00 76.15  ? 236 HIS A CD2 1 
ATOM 1730 C CE1 . HIS A 1 236 ? 127.116 135.793 136.985 1.00 78.30  ? 236 HIS A CE1 1 
ATOM 1731 N NE2 . HIS A 1 236 ? 126.709 134.810 137.767 1.00 79.52  ? 236 HIS A NE2 1 
ATOM 1732 N N   . PHE A 1 237 ? 121.117 134.962 135.098 1.00 70.19  ? 237 PHE A N   1 
ATOM 1733 C CA  . PHE A 1 237 ? 120.352 133.740 134.969 1.00 70.57  ? 237 PHE A CA  1 
ATOM 1734 C C   . PHE A 1 237 ? 120.002 133.438 133.523 1.00 65.31  ? 237 PHE A C   1 
ATOM 1735 O O   . PHE A 1 237 ? 119.855 132.268 133.150 1.00 61.54  ? 237 PHE A O   1 
ATOM 1736 C CB  . PHE A 1 237 ? 119.102 133.854 135.821 1.00 72.59  ? 237 PHE A CB  1 
ATOM 1737 C CG  . PHE A 1 237 ? 119.172 133.006 137.002 1.00 70.13  ? 237 PHE A CG  1 
ATOM 1738 C CD1 . PHE A 1 237 ? 119.556 133.519 138.227 1.00 72.94  ? 237 PHE A CD1 1 
ATOM 1739 C CD2 . PHE A 1 237 ? 119.007 131.658 136.858 1.00 71.79  ? 237 PHE A CD2 1 
ATOM 1740 C CE1 . PHE A 1 237 ? 119.669 132.689 139.313 1.00 74.34  ? 237 PHE A CE1 1 
ATOM 1741 C CE2 . PHE A 1 237 ? 119.133 130.854 137.902 1.00 68.70  ? 237 PHE A CE2 1 
ATOM 1742 C CZ  . PHE A 1 237 ? 119.453 131.342 139.147 1.00 72.89  ? 237 PHE A CZ  1 
ATOM 1743 N N   . TRP A 1 238 ? 119.864 134.478 132.706 1.00 65.23  ? 238 TRP A N   1 
ATOM 1744 C CA  . TRP A 1 238 ? 119.801 134.326 131.263 1.00 63.75  ? 238 TRP A CA  1 
ATOM 1745 C C   . TRP A 1 238 ? 121.177 134.082 130.663 1.00 65.70  ? 238 TRP A C   1 
ATOM 1746 O O   . TRP A 1 238 ? 121.269 133.710 129.489 1.00 62.02  ? 238 TRP A O   1 
ATOM 1747 C CB  . TRP A 1 238 ? 119.163 135.574 130.653 1.00 62.91  ? 238 TRP A CB  1 
ATOM 1748 C CG  . TRP A 1 238 ? 118.571 135.367 129.304 1.00 62.38  ? 238 TRP A CG  1 
ATOM 1749 C CD1 . TRP A 1 238 ? 119.221 135.419 128.109 1.00 58.75  ? 238 TRP A CD1 1 
ATOM 1750 C CD2 . TRP A 1 238 ? 117.200 135.089 129.003 1.00 62.49  ? 238 TRP A CD2 1 
ATOM 1751 N NE1 . TRP A 1 238 ? 118.344 135.180 127.083 1.00 58.86  ? 238 TRP A NE1 1 
ATOM 1752 C CE2 . TRP A 1 238 ? 117.095 134.977 127.605 1.00 63.77  ? 238 TRP A CE2 1 
ATOM 1753 C CE3 . TRP A 1 238 ? 116.052 134.920 129.780 1.00 60.24  ? 238 TRP A CE3 1 
ATOM 1754 C CZ2 . TRP A 1 238 ? 115.891 134.705 126.968 1.00 64.28  ? 238 TRP A CZ2 1 
ATOM 1755 C CZ3 . TRP A 1 238 ? 114.857 134.650 129.146 1.00 60.09  ? 238 TRP A CZ3 1 
ATOM 1756 C CH2 . TRP A 1 238 ? 114.785 134.545 127.754 1.00 61.55  ? 238 TRP A CH2 1 
ATOM 1757 N N   . LYS A 1 239 ? 122.240 134.274 131.452 1.00 65.04  ? 239 LYS A N   1 
ATOM 1758 C CA  . LYS A 1 239 ? 123.592 133.962 130.999 1.00 59.15  ? 239 LYS A CA  1 
ATOM 1759 C C   . LYS A 1 239 ? 123.750 132.487 130.651 1.00 57.78  ? 239 LYS A C   1 
ATOM 1760 O O   . LYS A 1 239 ? 124.603 132.138 129.830 1.00 57.42  ? 239 LYS A O   1 
ATOM 1761 C CB  . LYS A 1 239 ? 124.601 134.360 132.077 1.00 56.83  ? 239 LYS A CB  1 
ATOM 1762 C CG  . LYS A 1 239 ? 125.948 134.822 131.557 1.00 52.84  ? 239 LYS A CG  1 
ATOM 1763 C CD  . LYS A 1 239 ? 126.714 135.577 132.634 1.00 57.94  ? 239 LYS A CD  1 
ATOM 1764 C CE  . LYS A 1 239 ? 128.090 136.000 132.153 1.00 57.39  ? 239 LYS A CE  1 
ATOM 1765 N NZ  . LYS A 1 239 ? 128.026 137.226 131.315 1.00 52.95  ? 239 LYS A NZ  1 
ATOM 1766 N N   . ALA A 1 240 ? 122.951 131.612 131.267 1.00 61.53  ? 240 ALA A N   1 
ATOM 1767 C CA  . ALA A 1 240 ? 122.956 130.194 130.928 1.00 52.15  ? 240 ALA A CA  1 
ATOM 1768 C C   . ALA A 1 240 ? 122.184 129.883 129.650 1.00 56.40  ? 240 ALA A C   1 
ATOM 1769 O O   . ALA A 1 240 ? 122.468 128.872 128.996 1.00 55.09  ? 240 ALA A O   1 
ATOM 1770 C CB  . ALA A 1 240 ? 122.381 129.375 132.086 1.00 47.77  ? 240 ALA A CB  1 
ATOM 1771 N N   . PHE A 1 241 ? 121.229 130.733 129.271 1.00 61.61  ? 241 PHE A N   1 
ATOM 1772 C CA  . PHE A 1 241 ? 120.282 130.370 128.222 1.00 60.44  ? 241 PHE A CA  1 
ATOM 1773 C C   . PHE A 1 241 ? 120.923 130.392 126.841 1.00 57.48  ? 241 PHE A C   1 
ATOM 1774 O O   . PHE A 1 241 ? 120.705 129.482 126.032 1.00 57.73  ? 241 PHE A O   1 
ATOM 1775 C CB  . PHE A 1 241 ? 119.079 131.306 128.270 1.00 59.73  ? 241 PHE A CB  1 
ATOM 1776 C CG  . PHE A 1 241 ? 117.988 130.821 129.162 1.00 56.20  ? 241 PHE A CG  1 
ATOM 1777 C CD1 . PHE A 1 241 ? 117.196 129.762 128.776 1.00 53.06  ? 241 PHE A CD1 1 
ATOM 1778 C CD2 . PHE A 1 241 ? 117.765 131.413 130.394 1.00 58.17  ? 241 PHE A CD2 1 
ATOM 1779 C CE1 . PHE A 1 241 ? 116.201 129.307 129.592 1.00 55.81  ? 241 PHE A CE1 1 
ATOM 1780 C CE2 . PHE A 1 241 ? 116.762 130.961 131.220 1.00 58.46  ? 241 PHE A CE2 1 
ATOM 1781 C CZ  . PHE A 1 241 ? 115.977 129.906 130.818 1.00 58.74  ? 241 PHE A CZ  1 
ATOM 1782 N N   . TRP A 1 242 ? 121.705 131.429 126.544 1.00 50.26  ? 242 TRP A N   1 
ATOM 1783 C CA  . TRP A 1 242 ? 122.295 131.534 125.215 1.00 44.20  ? 242 TRP A CA  1 
ATOM 1784 C C   . TRP A 1 242 ? 123.401 130.507 125.018 1.00 44.26  ? 242 TRP A C   1 
ATOM 1785 O O   . TRP A 1 242 ? 123.642 130.057 123.891 1.00 42.50  ? 242 TRP A O   1 
ATOM 1786 C CB  . TRP A 1 242 ? 122.833 132.944 124.983 1.00 49.45  ? 242 TRP A CB  1 
ATOM 1787 C CG  . TRP A 1 242 ? 121.784 134.003 124.826 1.00 53.24  ? 242 TRP A CG  1 
ATOM 1788 C CD1 . TRP A 1 242 ? 121.607 135.097 125.618 1.00 56.95  ? 242 TRP A CD1 1 
ATOM 1789 C CD2 . TRP A 1 242 ? 120.790 134.089 123.796 1.00 49.60  ? 242 TRP A CD2 1 
ATOM 1790 N NE1 . TRP A 1 242 ? 120.560 135.853 125.156 1.00 52.21  ? 242 TRP A NE1 1 
ATOM 1791 C CE2 . TRP A 1 242 ? 120.040 135.255 124.039 1.00 52.37  ? 242 TRP A CE2 1 
ATOM 1792 C CE3 . TRP A 1 242 ? 120.458 133.292 122.695 1.00 46.62  ? 242 TRP A CE3 1 
ATOM 1793 C CZ2 . TRP A 1 242 ? 118.979 135.643 123.227 1.00 55.83  ? 242 TRP A CZ2 1 
ATOM 1794 C CZ3 . TRP A 1 242 ? 119.404 133.679 121.891 1.00 53.25  ? 242 TRP A CZ3 1 
ATOM 1795 C CH2 . TRP A 1 242 ? 118.676 134.843 122.160 1.00 59.63  ? 242 TRP A CH2 1 
ATOM 1796 N N   . ASN A 1 243 ? 124.082 130.120 126.096 1.00 54.36  ? 243 ASN A N   1 
ATOM 1797 C CA  . ASN A 1 243 ? 125.176 129.167 126.001 1.00 59.40  ? 243 ASN A CA  1 
ATOM 1798 C C   . ASN A 1 243 ? 124.787 127.780 126.519 1.00 57.96  ? 243 ASN A C   1 
ATOM 1799 O O   . ASN A 1 243 ? 125.663 126.986 126.869 1.00 63.01  ? 243 ASN A O   1 
ATOM 1800 C CB  . ASN A 1 243 ? 126.423 129.713 126.712 1.00 59.72  ? 243 ASN A CB  1 
ATOM 1801 C CG  . ASN A 1 243 ? 126.277 129.809 128.212 1.00 57.55  ? 243 ASN A CG  1 
ATOM 1802 O OD1 . ASN A 1 243 ? 125.200 129.642 128.758 1.00 60.06  ? 243 ASN A OD1 1 
ATOM 1803 N ND2 . ASN A 1 243 ? 127.383 130.091 128.888 1.00 54.02  ? 243 ASN A ND2 1 
ATOM 1804 N N   . ILE A 1 244 ? 123.485 127.493 126.614 1.00 58.77  ? 244 ILE A N   1 
ATOM 1805 C CA  . ILE A 1 244 ? 123.042 126.109 126.769 1.00 55.13  ? 244 ILE A CA  1 
ATOM 1806 C C   . ILE A 1 244 ? 123.387 125.256 125.552 1.00 54.83  ? 244 ILE A C   1 
ATOM 1807 O O   . ILE A 1 244 ? 123.394 124.024 125.652 1.00 60.39  ? 244 ILE A O   1 
ATOM 1808 C CB  . ILE A 1 244 ? 121.529 126.055 127.071 1.00 60.73  ? 244 ILE A CB  1 
ATOM 1809 C CG1 . ILE A 1 244 ? 121.214 124.895 128.016 1.00 58.73  ? 244 ILE A CG1 1 
ATOM 1810 C CG2 . ILE A 1 244 ? 120.700 125.940 125.794 1.00 59.02  ? 244 ILE A CG2 1 
ATOM 1811 C CD1 . ILE A 1 244 ? 121.738 125.088 129.416 1.00 58.74  ? 244 ILE A CD1 1 
ATOM 1812 N N   . THR A 1 245 ? 123.681 125.869 124.404 1.00 55.55  ? 245 THR A N   1 
ATOM 1813 C CA  . THR A 1 245 ? 124.218 125.157 123.255 1.00 55.19  ? 245 THR A CA  1 
ATOM 1814 C C   . THR A 1 245 ? 125.742 125.091 123.277 1.00 62.08  ? 245 THR A C   1 
ATOM 1815 O O   . THR A 1 245 ? 126.365 124.946 122.218 1.00 67.57  ? 245 THR A O   1 
ATOM 1816 C CB  . THR A 1 245 ? 123.735 125.801 121.954 1.00 55.69  ? 245 THR A CB  1 
ATOM 1817 O OG1 . THR A 1 245 ? 123.661 127.222 122.118 1.00 65.01  ? 245 THR A OG1 1 
ATOM 1818 C CG2 . THR A 1 245 ? 122.364 125.269 121.578 1.00 59.18  ? 245 THR A CG2 1 
ATOM 1819 N N   . GLU A 1 246 ? 126.352 125.206 124.463 1.00 74.25  ? 246 GLU A N   1 
ATOM 1820 C CA  . GLU A 1 246 ? 127.790 125.065 124.634 1.00 70.76  ? 246 GLU A CA  1 
ATOM 1821 C C   . GLU A 1 246 ? 128.204 123.823 125.403 1.00 68.95  ? 246 GLU A C   1 
ATOM 1822 O O   . GLU A 1 246 ? 129.348 123.384 125.245 1.00 68.86  ? 246 GLU A O   1 
ATOM 1823 C CB  . GLU A 1 246 ? 128.377 126.269 125.383 1.00 68.90  ? 246 GLU A CB  1 
ATOM 1824 C CG  . GLU A 1 246 ? 128.322 127.588 124.672 1.00 68.41  ? 246 GLU A CG  1 
ATOM 1825 C CD  . GLU A 1 246 ? 129.624 127.967 124.043 1.00 71.75  ? 246 GLU A CD  1 
ATOM 1826 O OE1 . GLU A 1 246 ? 129.704 127.888 122.812 1.00 69.72  ? 246 GLU A OE1 1 
ATOM 1827 O OE2 . GLU A 1 246 ? 130.568 128.325 124.777 1.00 71.95  ? 246 GLU A OE2 1 
ATOM 1828 N N   . MET A 1 247 ? 127.338 123.271 126.251 1.00 85.57  ? 247 MET A N   1 
ATOM 1829 C CA  . MET A 1 247 ? 127.751 122.156 127.089 1.00 90.11  ? 247 MET A CA  1 
ATOM 1830 C C   . MET A 1 247 ? 127.960 120.917 126.233 1.00 89.74  ? 247 MET A C   1 
ATOM 1831 O O   . MET A 1 247 ? 127.385 120.777 125.151 1.00 88.40  ? 247 MET A O   1 
ATOM 1832 C CB  . MET A 1 247 ? 126.741 121.890 128.211 1.00 88.08  ? 247 MET A CB  1 
ATOM 1833 C CG  . MET A 1 247 ? 125.293 121.742 127.810 1.00 85.38  ? 247 MET A CG  1 
ATOM 1834 S SD  . MET A 1 247 ? 124.136 121.754 129.211 0.50 84.22  ? 247 MET A SD  1 
ATOM 1835 C CE  . MET A 1 247 ? 125.014 122.731 130.422 1.00 86.29  ? 247 MET A CE  1 
ATOM 1836 N N   . GLU A 1 248 ? 128.790 120.010 126.743 1.00 94.77  ? 248 GLU A N   1 
ATOM 1837 C CA  . GLU A 1 248 ? 129.510 119.061 125.904 1.00 95.68  ? 248 GLU A CA  1 
ATOM 1838 C C   . GLU A 1 248 ? 128.611 118.003 125.271 1.00 96.09  ? 248 GLU A C   1 
ATOM 1839 O O   . GLU A 1 248 ? 129.079 117.253 124.408 1.00 99.98  ? 248 GLU A O   1 
ATOM 1840 C CB  . GLU A 1 248 ? 130.619 118.416 126.734 1.00 96.98  ? 248 GLU A CB  1 
ATOM 1841 C CG  . GLU A 1 248 ? 131.580 119.426 127.372 1.00 96.14  ? 248 GLU A CG  1 
ATOM 1842 C CD  . GLU A 1 248 ? 131.144 119.858 128.765 1.00 96.99  ? 248 GLU A CD  1 
ATOM 1843 O OE1 . GLU A 1 248 ? 131.439 119.133 129.736 1.00 97.55  ? 248 GLU A OE1 1 
ATOM 1844 O OE2 . GLU A 1 248 ? 130.496 120.920 128.884 1.00 94.64  ? 248 GLU A OE2 1 
ATOM 1845 N N   . VAL A 1 249 ? 127.343 117.917 125.672 1.00 80.59  ? 249 VAL A N   1 
ATOM 1846 C CA  . VAL A 1 249 ? 126.425 117.003 124.999 1.00 79.13  ? 249 VAL A CA  1 
ATOM 1847 C C   . VAL A 1 249 ? 125.763 117.674 123.796 1.00 84.20  ? 249 VAL A C   1 
ATOM 1848 O O   . VAL A 1 249 ? 125.795 117.138 122.684 1.00 84.85  ? 249 VAL A O   1 
ATOM 1849 C CB  . VAL A 1 249 ? 125.399 116.433 125.999 1.00 82.45  ? 249 VAL A CB  1 
ATOM 1850 C CG1 . VAL A 1 249 ? 126.044 115.359 126.828 1.00 79.88  ? 249 VAL A CG1 1 
ATOM 1851 C CG2 . VAL A 1 249 ? 124.893 117.516 126.945 1.00 86.40  ? 249 VAL A CG2 1 
ATOM 1852 N N   . LEU A 1 250 ? 125.183 118.868 123.979 1.00 83.79  ? 250 LEU A N   1 
ATOM 1853 C CA  . LEU A 1 250 ? 124.511 119.554 122.875 1.00 79.08  ? 250 LEU A CA  1 
ATOM 1854 C C   . LEU A 1 250 ? 125.474 120.200 121.888 1.00 76.60  ? 250 LEU A C   1 
ATOM 1855 O O   . LEU A 1 250 ? 125.146 120.284 120.702 1.00 75.75  ? 250 LEU A O   1 
ATOM 1856 C CB  . LEU A 1 250 ? 123.518 120.595 123.401 1.00 75.37  ? 250 LEU A CB  1 
ATOM 1857 C CG  . LEU A 1 250 ? 122.426 120.107 124.353 1.00 78.81  ? 250 LEU A CG  1 
ATOM 1858 C CD1 . LEU A 1 250 ? 122.701 120.411 125.783 1.00 79.26  ? 250 LEU A CD1 1 
ATOM 1859 C CD2 . LEU A 1 250 ? 121.135 120.796 123.942 1.00 79.06  ? 250 LEU A CD2 1 
ATOM 1860 N N   . SER A 1 251 ? 126.652 120.657 122.329 1.00 76.18  ? 251 SER A N   1 
ATOM 1861 C CA  . SER A 1 251 ? 127.633 121.154 121.364 1.00 79.96  ? 251 SER A CA  1 
ATOM 1862 C C   . SER A 1 251 ? 128.115 120.040 120.440 1.00 83.10  ? 251 SER A C   1 
ATOM 1863 O O   . SER A 1 251 ? 128.389 120.285 119.259 1.00 83.19  ? 251 SER A O   1 
ATOM 1864 C CB  . SER A 1 251 ? 128.817 121.802 122.084 1.00 82.84  ? 251 SER A CB  1 
ATOM 1865 O OG  . SER A 1 251 ? 129.345 120.945 123.079 1.00 84.58  ? 251 SER A OG  1 
ATOM 1866 N N   . SER A 1 252 ? 128.205 118.813 120.954 1.00 82.58  ? 252 SER A N   1 
ATOM 1867 C CA  . SER A 1 252 ? 128.528 117.661 120.120 1.00 79.37  ? 252 SER A CA  1 
ATOM 1868 C C   . SER A 1 252 ? 127.330 117.204 119.294 1.00 83.64  ? 252 SER A C   1 
ATOM 1869 O O   . SER A 1 252 ? 127.497 116.757 118.154 1.00 81.35  ? 252 SER A O   1 
ATOM 1870 C CB  . SER A 1 252 ? 129.037 116.516 120.994 1.00 78.89  ? 252 SER A CB  1 
ATOM 1871 O OG  . SER A 1 252 ? 128.130 116.246 122.047 0.46 81.72  ? 252 SER A OG  1 
ATOM 1872 N N   . LEU A 1 253 ? 126.120 117.306 119.847 1.00 87.38  ? 253 LEU A N   1 
ATOM 1873 C CA  . LEU A 1 253 ? 124.915 116.827 119.183 1.00 79.98  ? 253 LEU A CA  1 
ATOM 1874 C C   . LEU A 1 253 ? 124.342 117.824 118.182 1.00 81.78  ? 253 LEU A C   1 
ATOM 1875 O O   . LEU A 1 253 ? 123.389 117.490 117.473 1.00 84.09  ? 253 LEU A O   1 
ATOM 1876 C CB  . LEU A 1 253 ? 123.856 116.483 120.236 1.00 76.50  ? 253 LEU A CB  1 
ATOM 1877 C CG  . LEU A 1 253 ? 122.790 115.436 119.910 1.00 77.43  ? 253 LEU A CG  1 
ATOM 1878 C CD1 . LEU A 1 253 ? 123.405 114.242 119.203 1.00 78.11  ? 253 LEU A CD1 1 
ATOM 1879 C CD2 . LEU A 1 253 ? 122.069 115.001 121.175 1.00 83.83  ? 253 LEU A CD2 1 
ATOM 1880 N N   . ALA A 1 254 ? 124.872 119.041 118.123 1.00 79.63  ? 254 ALA A N   1 
ATOM 1881 C CA  . ALA A 1 254 ? 124.415 120.021 117.151 1.00 79.76  ? 254 ALA A CA  1 
ATOM 1882 C C   . ALA A 1 254 ? 125.282 120.066 115.902 1.00 78.50  ? 254 ALA A C   1 
ATOM 1883 O O   . ALA A 1 254 ? 125.079 120.945 115.059 1.00 78.68  ? 254 ALA A O   1 
ATOM 1884 C CB  . ALA A 1 254 ? 124.366 121.411 117.790 1.00 80.33  ? 254 ALA A CB  1 
ATOM 1885 N N   . ASN A 1 255 ? 126.230 119.143 115.754 1.00 84.70  ? 255 ASN A N   1 
ATOM 1886 C CA  . ASN A 1 255 ? 127.257 119.255 114.729 1.00 88.26  ? 255 ASN A CA  1 
ATOM 1887 C C   . ASN A 1 255 ? 127.111 118.267 113.579 1.00 90.18  ? 255 ASN A C   1 
ATOM 1888 O O   . ASN A 1 255 ? 127.975 118.251 112.696 1.00 92.16  ? 255 ASN A O   1 
ATOM 1889 C CB  . ASN A 1 255 ? 128.644 119.100 115.363 1.00 91.75  ? 255 ASN A CB  1 
ATOM 1890 C CG  . ASN A 1 255 ? 129.204 120.416 115.865 1.00 88.03  ? 255 ASN A CG  1 
ATOM 1891 O OD1 . ASN A 1 255 ? 130.073 121.015 115.233 1.00 87.32  ? 255 ASN A OD1 1 
ATOM 1892 N ND2 . ASN A 1 255 ? 128.704 120.875 117.005 1.00 87.75  ? 255 ASN A ND2 1 
ATOM 1893 N N   . MET A 1 256 ? 126.061 117.442 113.551 1.00 86.20  ? 256 MET A N   1 
ATOM 1894 C CA  . MET A 1 256 ? 125.867 116.600 112.373 1.00 87.96  ? 256 MET A CA  1 
ATOM 1895 C C   . MET A 1 256 ? 125.340 117.392 111.185 1.00 87.27  ? 256 MET A C   1 
ATOM 1896 O O   . MET A 1 256 ? 125.622 117.035 110.036 1.00 86.44  ? 256 MET A O   1 
ATOM 1897 C CB  . MET A 1 256 ? 124.929 115.431 112.677 1.00 85.92  ? 256 MET A CB  1 
ATOM 1898 C CG  . MET A 1 256 ? 125.278 114.652 113.927 1.00 88.39  ? 256 MET A CG  1 
ATOM 1899 S SD  . MET A 1 256 ? 124.743 115.478 115.426 0.40 86.60  ? 256 MET A SD  1 
ATOM 1900 C CE  . MET A 1 256 ? 123.069 114.849 115.542 1.00 86.04  ? 256 MET A CE  1 
ATOM 1901 N N   . ALA A 1 257 ? 124.583 118.462 111.433 1.00 87.48  ? 257 ALA A N   1 
ATOM 1902 C CA  . ALA A 1 257 ? 124.168 119.338 110.345 1.00 87.09  ? 257 ALA A CA  1 
ATOM 1903 C C   . ALA A 1 257 ? 125.311 120.215 109.852 1.00 87.27  ? 257 ALA A C   1 
ATOM 1904 O O   . ALA A 1 257 ? 125.219 120.768 108.750 1.00 84.08  ? 257 ALA A O   1 
ATOM 1905 C CB  . ALA A 1 257 ? 122.992 120.209 110.786 1.00 81.22  ? 257 ALA A CB  1 
ATOM 1906 N N   . SER A 1 258 ? 126.374 120.356 110.640 1.00 74.82  ? 258 SER A N   1 
ATOM 1907 C CA  . SER A 1 258 ? 127.533 121.130 110.222 1.00 73.91  ? 258 SER A CA  1 
ATOM 1908 C C   . SER A 1 258 ? 128.275 120.418 109.097 1.00 79.00  ? 258 SER A C   1 
ATOM 1909 O O   . SER A 1 258 ? 128.305 119.187 109.034 1.00 81.53  ? 258 SER A O   1 
ATOM 1910 C CB  . SER A 1 258 ? 128.467 121.362 111.408 1.00 76.25  ? 258 SER A CB  1 
ATOM 1911 O OG  . SER A 1 258 ? 129.039 120.145 111.852 1.00 75.69  ? 258 SER A OG  1 
ATOM 1912 N N   . ALA A 1 259 ? 128.876 121.203 108.207 1.00 71.83  ? 259 ALA A N   1 
ATOM 1913 C CA  . ALA A 1 259 ? 129.556 120.662 107.041 1.00 73.41  ? 259 ALA A CA  1 
ATOM 1914 C C   . ALA A 1 259 ? 130.927 120.101 107.422 1.00 71.30  ? 259 ALA A C   1 
ATOM 1915 O O   . ALA A 1 259 ? 131.352 120.142 108.580 1.00 70.94  ? 259 ALA A O   1 
ATOM 1916 C CB  . ALA A 1 259 ? 129.680 121.731 105.957 1.00 72.95  ? 259 ALA A CB  1 
ATOM 1917 N N   . THR A 1 260 ? 131.625 119.564 106.423 1.00 69.99  ? 260 THR A N   1 
ATOM 1918 C CA  . THR A 1 260 ? 132.930 118.954 106.646 1.00 68.47  ? 260 THR A CA  1 
ATOM 1919 C C   . THR A 1 260 ? 133.996 120.016 106.884 1.00 71.56  ? 260 THR A C   1 
ATOM 1920 O O   . THR A 1 260 ? 133.886 121.150 106.409 1.00 66.45  ? 260 THR A O   1 
ATOM 1921 C CB  . THR A 1 260 ? 133.325 118.088 105.450 1.00 72.19  ? 260 THR A CB  1 
ATOM 1922 O OG1 . THR A 1 260 ? 133.793 118.926 104.386 1.00 77.77  ? 260 THR A OG1 1 
ATOM 1923 C CG2 . THR A 1 260 ? 132.133 117.280 104.964 1.00 71.71  ? 260 THR A CG2 1 
ATOM 1924 N N   . VAL A 1 261 ? 135.042 119.635 107.617 1.00 67.86  ? 261 VAL A N   1 
ATOM 1925 C CA  . VAL A 1 261 ? 136.077 120.573 108.037 1.00 66.06  ? 261 VAL A CA  1 
ATOM 1926 C C   . VAL A 1 261 ? 137.323 119.770 108.389 1.00 58.57  ? 261 VAL A C   1 
ATOM 1927 O O   . VAL A 1 261 ? 137.276 118.545 108.521 1.00 56.86  ? 261 VAL A O   1 
ATOM 1928 C CB  . VAL A 1 261 ? 135.592 121.419 109.243 1.00 57.98  ? 261 VAL A CB  1 
ATOM 1929 C CG1 . VAL A 1 261 ? 135.756 120.630 110.537 1.00 56.90  ? 261 VAL A CG1 1 
ATOM 1930 C CG2 . VAL A 1 261 ? 136.283 122.783 109.295 1.00 48.86  ? 261 VAL A CG2 1 
ATOM 1931 N N   . ARG A 1 262 ? 138.455 120.457 108.489 1.00 46.08  ? 262 ARG A N   1 
ATOM 1932 C CA  . ARG A 1 262 ? 139.639 119.924 109.147 1.00 41.90  ? 262 ARG A CA  1 
ATOM 1933 C C   . ARG A 1 262 ? 140.246 120.890 110.153 1.00 45.64  ? 262 ARG A C   1 
ATOM 1934 O O   . ARG A 1 262 ? 140.711 120.460 111.211 1.00 45.71  ? 262 ARG A O   1 
ATOM 1935 C CB  . ARG A 1 262 ? 140.687 119.540 108.100 1.00 51.71  ? 262 ARG A CB  1 
ATOM 1936 C CG  . ARG A 1 262 ? 141.033 120.661 107.148 1.00 49.45  ? 262 ARG A CG  1 
ATOM 1937 C CD  . ARG A 1 262 ? 141.413 120.119 105.786 1.00 47.15  ? 262 ARG A CD  1 
ATOM 1938 N NE  . ARG A 1 262 ? 140.422 119.178 105.279 1.00 52.65  ? 262 ARG A NE  1 
ATOM 1939 C CZ  . ARG A 1 262 ? 139.207 119.517 104.871 1.00 47.66  ? 262 ARG A CZ  1 
ATOM 1940 N NH1 . ARG A 1 262 ? 138.809 120.777 104.862 1.00 51.92  ? 262 ARG A NH1 1 
ATOM 1941 N NH2 . ARG A 1 262 ? 138.371 118.568 104.461 1.00 47.41  ? 262 ARG A NH2 1 
ATOM 1942 N N   . VAL A 1 263 ? 140.239 122.187 109.856 1.00 35.81  ? 263 VAL A N   1 
ATOM 1943 C CA  . VAL A 1 263 ? 140.937 123.187 110.656 1.00 35.75  ? 263 VAL A CA  1 
ATOM 1944 C C   . VAL A 1 263 ? 139.914 123.836 111.584 1.00 27.70  ? 263 VAL A C   1 
ATOM 1945 O O   . VAL A 1 263 ? 139.100 124.653 111.156 1.00 32.66  ? 263 VAL A O   1 
ATOM 1946 C CB  . VAL A 1 263 ? 141.632 124.221 109.770 1.00 33.78  ? 263 VAL A CB  1 
ATOM 1947 C CG1 . VAL A 1 263 ? 142.570 125.076 110.585 1.00 37.41  ? 263 VAL A CG1 1 
ATOM 1948 C CG2 . VAL A 1 263 ? 142.370 123.534 108.638 1.00 33.17  ? 263 VAL A CG2 1 
ATOM 1949 N N   . SER A 1 264 ? 139.956 123.470 112.861 1.00 30.24  ? 264 SER A N   1 
ATOM 1950 C CA  . SER A 1 264 ? 139.060 124.024 113.873 1.00 29.89  ? 264 SER A CA  1 
ATOM 1951 C C   . SER A 1 264 ? 139.844 124.344 115.140 1.00 29.68  ? 264 SER A C   1 
ATOM 1952 O O   . SER A 1 264 ? 139.442 124.008 116.254 1.00 27.39  ? 264 SER A O   1 
ATOM 1953 C CB  . SER A 1 264 ? 137.908 123.068 114.172 1.00 28.75  ? 264 SER A CB  1 
ATOM 1954 O OG  . SER A 1 264 ? 137.106 123.559 115.231 1.00 16.70  ? 264 SER A OG  1 
ATOM 1955 N N   . ARG A 1 265 ? 140.979 125.013 114.975 1.00 27.99  ? 265 ARG A N   1 
ATOM 1956 C CA  . ARG A 1 265 ? 141.964 125.177 116.033 1.00 27.50  ? 265 ARG A CA  1 
ATOM 1957 C C   . ARG A 1 265 ? 141.850 126.548 116.682 1.00 25.59  ? 265 ARG A C   1 
ATOM 1958 O O   . ARG A 1 265 ? 141.657 127.557 115.998 1.00 30.60  ? 265 ARG A O   1 
ATOM 1959 C CB  . ARG A 1 265 ? 143.374 124.994 115.476 1.00 30.87  ? 265 ARG A CB  1 
ATOM 1960 C CG  . ARG A 1 265 ? 143.521 125.545 114.075 1.00 29.73  ? 265 ARG A CG  1 
ATOM 1961 C CD  . ARG A 1 265 ? 144.880 125.237 113.503 1.00 32.13  ? 265 ARG A CD  1 
ATOM 1962 N NE  . ARG A 1 265 ? 145.938 125.727 114.373 1.00 33.31  ? 265 ARG A NE  1 
ATOM 1963 C CZ  . ARG A 1 265 ? 147.070 125.081 114.604 1.00 37.20  ? 265 ARG A CZ  1 
ATOM 1964 N NH1 . ARG A 1 265 ? 147.327 123.912 114.041 1.00 42.66  ? 265 ARG A NH1 1 
ATOM 1965 N NH2 . ARG A 1 265 ? 147.967 125.620 115.422 1.00 35.08  ? 265 ARG A NH2 1 
ATOM 1966 N N   . LEU A 1 266 ? 141.985 126.576 118.004 1.00 17.21  ? 266 LEU A N   1 
ATOM 1967 C CA  . LEU A 1 266 ? 142.035 127.819 118.752 1.00 17.92  ? 266 LEU A CA  1 
ATOM 1968 C C   . LEU A 1 266 ? 143.417 128.456 118.626 1.00 19.68  ? 266 LEU A C   1 
ATOM 1969 O O   . LEU A 1 266 ? 144.384 127.829 118.190 1.00 27.30  ? 266 LEU A O   1 
ATOM 1970 C CB  . LEU A 1 266 ? 141.704 127.574 120.223 1.00 16.50  ? 266 LEU A CB  1 
ATOM 1971 C CG  . LEU A 1 266 ? 140.240 127.591 120.659 1.00 27.26  ? 266 LEU A CG  1 
ATOM 1972 C CD1 . LEU A 1 266 ? 139.561 126.270 120.344 1.00 23.64  ? 266 LEU A CD1 1 
ATOM 1973 C CD2 . LEU A 1 266 ? 140.145 127.900 122.142 1.00 23.88  ? 266 LEU A CD2 1 
ATOM 1974 N N   . LEU A 1 267 ? 143.502 129.727 119.008 1.00 25.50  ? 267 LEU A N   1 
ATOM 1975 C CA  . LEU A 1 267 ? 144.769 130.441 119.055 1.00 27.33  ? 267 LEU A CA  1 
ATOM 1976 C C   . LEU A 1 267 ? 144.894 131.135 120.401 1.00 30.38  ? 267 LEU A C   1 
ATOM 1977 O O   . LEU A 1 267 ? 143.954 131.162 121.198 1.00 35.69  ? 267 LEU A O   1 
ATOM 1978 C CB  . LEU A 1 267 ? 144.904 131.478 117.934 1.00 25.18  ? 267 LEU A CB  1 
ATOM 1979 C CG  . LEU A 1 267 ? 145.422 131.088 116.549 1.00 20.64  ? 267 LEU A CG  1 
ATOM 1980 C CD1 . LEU A 1 267 ? 144.462 130.187 115.794 1.00 15.63  ? 267 LEU A CD1 1 
ATOM 1981 C CD2 . LEU A 1 267 ? 145.713 132.343 115.749 1.00 38.13  ? 267 LEU A CD2 1 
ATOM 1982 N N   . SER A 1 268 ? 146.074 131.698 120.649 1.00 24.89  ? 268 SER A N   1 
ATOM 1983 C CA  . SER A 1 268 ? 146.341 132.447 121.878 1.00 34.38  ? 268 SER A CA  1 
ATOM 1984 C C   . SER A 1 268 ? 147.296 133.582 121.527 1.00 41.29  ? 268 SER A C   1 
ATOM 1985 O O   . SER A 1 268 ? 148.494 133.356 121.332 1.00 43.65  ? 268 SER A O   1 
ATOM 1986 C CB  . SER A 1 268 ? 146.918 131.549 122.965 1.00 39.13  ? 268 SER A CB  1 
ATOM 1987 O OG  . SER A 1 268 ? 147.017 132.241 124.197 1.00 38.11  ? 268 SER A OG  1 
ATOM 1988 N N   . LEU A 1 269 ? 146.763 134.797 121.445 1.00 49.57  ? 269 LEU A N   1 
ATOM 1989 C CA  . LEU A 1 269 ? 147.559 135.950 121.062 1.00 49.06  ? 269 LEU A CA  1 
ATOM 1990 C C   . LEU A 1 269 ? 148.373 136.472 122.246 1.00 54.54  ? 269 LEU A C   1 
ATOM 1991 O O   . LEU A 1 269 ? 147.937 136.378 123.397 1.00 56.45  ? 269 LEU A O   1 
ATOM 1992 C CB  . LEU A 1 269 ? 146.659 137.054 120.517 1.00 47.52  ? 269 LEU A CB  1 
ATOM 1993 C CG  . LEU A 1 269 ? 145.767 136.639 119.347 1.00 48.27  ? 269 LEU A CG  1 
ATOM 1994 C CD1 . LEU A 1 269 ? 145.084 137.848 118.744 0.34 50.79  ? 269 LEU A CD1 1 
ATOM 1995 C CD2 . LEU A 1 269 ? 146.570 135.899 118.293 1.00 41.54  ? 269 LEU A CD2 1 
ATOM 1996 N N   . PRO A 1 270 ? 149.563 137.013 121.992 1.00 71.57  ? 270 PRO A N   1 
ATOM 1997 C CA  . PRO A 1 270 ? 150.391 137.540 123.084 1.00 76.56  ? 270 PRO A CA  1 
ATOM 1998 C C   . PRO A 1 270 ? 149.806 138.820 123.652 1.00 77.13  ? 270 PRO A C   1 
ATOM 1999 O O   . PRO A 1 270 ? 149.257 139.648 122.909 1.00 69.99  ? 270 PRO A O   1 
ATOM 2000 C CB  . PRO A 1 270 ? 151.745 137.798 122.406 1.00 73.35  ? 270 PRO A CB  1 
ATOM 2001 C CG  . PRO A 1 270 ? 151.410 138.002 120.971 1.00 70.04  ? 270 PRO A CG  1 
ATOM 2002 C CD  . PRO A 1 270 ? 150.257 137.085 120.693 1.00 69.23  ? 270 PRO A CD  1 
ATOM 2003 N N   . PRO A 1 271 ? 149.904 139.023 124.977 1.00 82.76  ? 271 PRO A N   1 
ATOM 2004 C CA  . PRO A 1 271 ? 149.390 140.242 125.612 1.00 77.99  ? 271 PRO A CA  1 
ATOM 2005 C C   . PRO A 1 271 ? 150.395 141.393 125.617 1.00 71.98  ? 271 PRO A C   1 
ATOM 2006 O O   . PRO A 1 271 ? 150.660 142.012 126.654 1.00 70.42  ? 271 PRO A O   1 
ATOM 2007 C CB  . PRO A 1 271 ? 149.066 139.775 127.036 1.00 79.87  ? 271 PRO A CB  1 
ATOM 2008 C CG  . PRO A 1 271 ? 149.355 138.281 127.076 1.00 77.78  ? 271 PRO A CG  1 
ATOM 2009 C CD  . PRO A 1 271 ? 150.320 138.031 125.978 1.00 82.42  ? 271 PRO A CD  1 
ATOM 2010 N N   . GLU A 1 272 ? 150.966 141.691 124.453 1.00 80.81  ? 272 GLU A N   1 
ATOM 2011 C CA  . GLU A 1 272 ? 151.908 142.792 124.321 1.00 80.37  ? 272 GLU A CA  1 
ATOM 2012 C C   . GLU A 1 272 ? 151.666 143.502 122.997 1.00 85.64  ? 272 GLU A C   1 
ATOM 2013 O O   . GLU A 1 272 ? 151.268 142.882 122.007 1.00 80.45  ? 272 GLU A O   1 
ATOM 2014 C CB  . GLU A 1 272 ? 153.361 142.305 124.412 1.00 82.92  ? 272 GLU A CB  1 
ATOM 2015 C CG  . GLU A 1 272 ? 154.367 143.374 124.827 1.00 84.24  ? 272 GLU A CG  1 
ATOM 2016 C CD  . GLU A 1 272 ? 153.963 144.108 126.093 1.00 84.65  ? 272 GLU A CD  1 
ATOM 2017 O OE1 . GLU A 1 272 ? 153.360 145.199 125.992 1.00 81.52  ? 272 GLU A OE1 1 
ATOM 2018 O OE2 . GLU A 1 272 ? 154.249 143.591 127.193 1.00 85.91  ? 272 GLU A OE2 1 
ATOM 2019 N N   . ALA A 1 273 ? 151.920 144.809 122.988 1.00 75.08  ? 273 ALA A N   1 
ATOM 2020 C CA  . ALA A 1 273 ? 151.647 145.630 121.820 1.00 76.87  ? 273 ALA A CA  1 
ATOM 2021 C C   . ALA A 1 273 ? 152.663 145.353 120.714 1.00 73.67  ? 273 ALA A C   1 
ATOM 2022 O O   . ALA A 1 273 ? 153.725 144.762 120.932 1.00 74.51  ? 273 ALA A O   1 
ATOM 2023 C CB  . ALA A 1 273 ? 151.664 147.112 122.189 1.00 75.05  ? 273 ALA A CB  1 
ATOM 2024 N N   . PHE A 1 274 ? 152.321 145.793 119.508 1.00 64.91  ? 274 PHE A N   1 
ATOM 2025 C CA  . PHE A 1 274 ? 153.191 145.634 118.353 1.00 64.08  ? 274 PHE A CA  1 
ATOM 2026 C C   . PHE A 1 274 ? 153.059 146.880 117.484 1.00 65.35  ? 274 PHE A C   1 
ATOM 2027 O O   . PHE A 1 274 ? 152.497 147.897 117.902 1.00 68.00  ? 274 PHE A O   1 
ATOM 2028 C CB  . PHE A 1 274 ? 152.872 144.335 117.598 1.00 65.11  ? 274 PHE A CB  1 
ATOM 2029 C CG  . PHE A 1 274 ? 151.482 144.275 117.028 1.00 60.38  ? 274 PHE A CG  1 
ATOM 2030 C CD1 . PHE A 1 274 ? 150.416 143.851 117.805 1.00 64.51  ? 274 PHE A CD1 1 
ATOM 2031 C CD2 . PHE A 1 274 ? 151.247 144.613 115.705 1.00 55.89  ? 274 PHE A CD2 1 
ATOM 2032 C CE1 . PHE A 1 274 ? 149.143 143.788 117.281 1.00 63.60  ? 274 PHE A CE1 1 
ATOM 2033 C CE2 . PHE A 1 274 ? 149.977 144.552 115.177 1.00 62.59  ? 274 PHE A CE2 1 
ATOM 2034 C CZ  . PHE A 1 274 ? 148.924 144.140 115.966 1.00 64.78  ? 274 PHE A CZ  1 
ATOM 2035 N N   . GLU A 1 275 ? 153.581 146.796 116.266 1.00 70.82  ? 275 GLU A N   1 
ATOM 2036 C CA  . GLU A 1 275 ? 153.713 147.939 115.376 1.00 70.80  ? 275 GLU A CA  1 
ATOM 2037 C C   . GLU A 1 275 ? 152.678 147.862 114.262 1.00 73.82  ? 275 GLU A C   1 
ATOM 2038 O O   . GLU A 1 275 ? 152.478 146.803 113.659 1.00 71.28  ? 275 GLU A O   1 
ATOM 2039 C CB  . GLU A 1 275 ? 155.123 147.990 114.782 1.00 71.20  ? 275 GLU A CB  1 
ATOM 2040 C CG  . GLU A 1 275 ? 155.343 149.053 113.726 1.00 70.71  ? 275 GLU A CG  1 
ATOM 2041 C CD  . GLU A 1 275 ? 155.949 150.313 114.301 1.00 76.74  ? 275 GLU A CD  1 
ATOM 2042 O OE1 . GLU A 1 275 ? 155.807 150.541 115.521 1.00 79.34  ? 275 GLU A OE1 1 
ATOM 2043 O OE2 . GLU A 1 275 ? 156.579 151.072 113.537 1.00 76.90  ? 275 GLU A OE2 1 
ATOM 2044 N N   . MET A 1 276 ? 152.019 148.993 113.995 1.00 67.56  ? 276 MET A N   1 
ATOM 2045 C CA  . MET A 1 276 ? 151.025 149.071 112.934 1.00 65.55  ? 276 MET A CA  1 
ATOM 2046 C C   . MET A 1 276 ? 151.010 150.463 112.329 1.00 68.36  ? 276 MET A C   1 
ATOM 2047 O O   . MET A 1 276 ? 151.052 151.451 113.075 1.00 66.33  ? 276 MET A O   1 
ATOM 2048 C CB  . MET A 1 276 ? 149.635 148.685 113.454 1.00 65.28  ? 276 MET A CB  1 
ATOM 2049 C CG  . MET A 1 276 ? 149.190 149.366 114.735 1.00 65.44  ? 276 MET A CG  1 
ATOM 2050 S SD  . MET A 1 276 ? 147.783 148.471 115.419 1.00 46.76  ? 276 MET A SD  1 
ATOM 2051 C CE  . MET A 1 276 ? 147.871 148.924 117.144 1.00 54.98  ? 276 MET A CE  1 
ATOM 2052 N N   . PRO A 1 277 ? 150.973 150.583 110.998 1.00 69.82  ? 277 PRO A N   1 
ATOM 2053 C CA  . PRO A 1 277 ? 151.012 151.907 110.366 1.00 71.75  ? 277 PRO A CA  1 
ATOM 2054 C C   . PRO A 1 277 ? 149.633 152.518 110.182 1.00 67.03  ? 277 PRO A C   1 
ATOM 2055 O O   . PRO A 1 277 ? 148.628 151.955 110.625 1.00 67.95  ? 277 PRO A O   1 
ATOM 2056 C CB  . PRO A 1 277 ? 151.683 151.630 109.011 1.00 73.79  ? 277 PRO A CB  1 
ATOM 2057 C CG  . PRO A 1 277 ? 151.804 150.107 108.900 1.00 64.62  ? 277 PRO A CG  1 
ATOM 2058 C CD  . PRO A 1 277 ? 150.987 149.509 109.997 1.00 61.83  ? 277 PRO A CD  1 
ATOM 2059 N N   . LEU A 1 278 ? 149.582 153.679 109.532 1.00 72.49  ? 278 LEU A N   1 
ATOM 2060 C CA  . LEU A 1 278 ? 148.333 154.350 109.206 1.00 78.16  ? 278 LEU A CA  1 
ATOM 2061 C C   . LEU A 1 278 ? 148.346 154.768 107.741 1.00 78.60  ? 278 LEU A C   1 
ATOM 2062 O O   . LEU A 1 278 ? 149.402 155.044 107.167 1.00 75.97  ? 278 LEU A O   1 
ATOM 2063 C CB  . LEU A 1 278 ? 148.094 155.555 110.138 1.00 75.83  ? 278 LEU A CB  1 
ATOM 2064 C CG  . LEU A 1 278 ? 149.185 156.612 110.344 1.00 75.64  ? 278 LEU A CG  1 
ATOM 2065 C CD1 . LEU A 1 278 ? 149.104 157.744 109.333 1.00 75.92  ? 278 LEU A CD1 1 
ATOM 2066 C CD2 . LEU A 1 278 ? 149.126 157.161 111.764 1.00 75.18  ? 278 LEU A CD2 1 
ATOM 2067 N N   . THR A 1 279 ? 147.151 154.811 107.141 1.00 79.29  ? 279 THR A N   1 
ATOM 2068 C CA  . THR A 1 279 ? 147.030 155.002 105.698 1.00 79.91  ? 279 THR A CA  1 
ATOM 2069 C C   . THR A 1 279 ? 147.367 156.425 105.263 1.00 81.58  ? 279 THR A C   1 
ATOM 2070 O O   . THR A 1 279 ? 147.760 156.627 104.108 1.00 82.43  ? 279 THR A O   1 
ATOM 2071 C CB  . THR A 1 279 ? 145.611 154.641 105.241 1.00 81.97  ? 279 THR A CB  1 
ATOM 2072 O OG1 . THR A 1 279 ? 145.160 153.488 105.963 1.00 80.73  ? 279 THR A OG1 1 
ATOM 2073 C CG2 . THR A 1 279 ? 145.578 154.316 103.751 1.00 82.62  ? 279 THR A CG2 1 
ATOM 2074 N N   . ALA A 1 280 ? 147.234 157.409 106.159 1.00 86.90  ? 280 ALA A N   1 
ATOM 2075 C CA  . ALA A 1 280 ? 147.510 158.796 105.790 1.00 87.80  ? 280 ALA A CA  1 
ATOM 2076 C C   . ALA A 1 280 ? 148.981 159.013 105.456 1.00 86.63  ? 280 ALA A C   1 
ATOM 2077 O O   . ALA A 1 280 ? 149.309 159.874 104.632 1.00 84.85  ? 280 ALA A O   1 
ATOM 2078 C CB  . ALA A 1 280 ? 147.075 159.735 106.915 1.00 86.20  ? 280 ALA A CB  1 
ATOM 2079 N N   . ASP A 1 281 ? 149.872 158.247 106.076 1.00 80.12  ? 281 ASP A N   1 
ATOM 2080 C CA  . ASP A 1 281 ? 151.291 158.270 105.749 1.00 80.47  ? 281 ASP A CA  1 
ATOM 2081 C C   . ASP A 1 281 ? 151.889 156.901 106.047 1.00 81.70  ? 281 ASP A C   1 
ATOM 2082 O O   . ASP A 1 281 ? 152.001 156.517 107.218 1.00 83.28  ? 281 ASP A O   1 
ATOM 2083 C CB  . ASP A 1 281 ? 152.016 159.365 106.534 1.00 79.83  ? 281 ASP A CB  1 
ATOM 2084 C CG  . ASP A 1 281 ? 153.348 159.742 105.913 1.00 79.36  ? 281 ASP A CG  1 
ATOM 2085 O OD1 . ASP A 1 281 ? 154.305 158.948 106.026 1.00 80.06  ? 281 ASP A OD1 1 
ATOM 2086 O OD2 . ASP A 1 281 ? 153.438 160.832 105.310 1.00 79.87  ? 281 ASP A OD2 1 
ATOM 2087 N N   . PRO A 1 282 ? 152.251 156.129 105.017 1.00 81.17  ? 282 PRO A N   1 
ATOM 2088 C CA  . PRO A 1 282 ? 152.820 154.790 105.260 1.00 80.33  ? 282 PRO A CA  1 
ATOM 2089 C C   . PRO A 1 282 ? 154.139 154.805 106.015 1.00 78.01  ? 282 PRO A C   1 
ATOM 2090 O O   . PRO A 1 282 ? 154.444 153.838 106.724 1.00 76.19  ? 282 PRO A O   1 
ATOM 2091 C CB  . PRO A 1 282 ? 152.989 154.221 103.843 1.00 80.15  ? 282 PRO A CB  1 
ATOM 2092 C CG  . PRO A 1 282 ? 152.055 155.022 102.989 1.00 77.66  ? 282 PRO A CG  1 
ATOM 2093 C CD  . PRO A 1 282 ? 152.053 156.395 103.583 1.00 78.22  ? 282 PRO A CD  1 
ATOM 2094 N N   . THR A 1 283 ? 154.932 155.870 105.887 1.00 77.42  ? 283 THR A N   1 
ATOM 2095 C CA  . THR A 1 283 ? 156.200 155.953 106.602 1.00 77.33  ? 283 THR A CA  1 
ATOM 2096 C C   . THR A 1 283 ? 156.023 156.201 108.094 1.00 78.55  ? 283 THR A C   1 
ATOM 2097 O O   . THR A 1 283 ? 156.968 155.973 108.856 1.00 77.21  ? 283 THR A O   1 
ATOM 2098 C CB  . THR A 1 283 ? 157.075 157.056 106.004 1.00 79.30  ? 283 THR A CB  1 
ATOM 2099 O OG1 . THR A 1 283 ? 156.659 158.329 106.516 1.00 77.33  ? 283 THR A OG1 1 
ATOM 2100 C CG2 . THR A 1 283 ? 156.962 157.062 104.487 1.00 78.36  ? 283 THR A CG2 1 
ATOM 2101 N N   . LEU A 1 284 ? 154.852 156.658 108.527 1.00 75.40  ? 284 LEU A N   1 
ATOM 2102 C CA  . LEU A 1 284 ? 154.570 156.888 109.936 1.00 75.18  ? 284 LEU A CA  1 
ATOM 2103 C C   . LEU A 1 284 ? 153.655 155.794 110.468 1.00 74.24  ? 284 LEU A C   1 
ATOM 2104 O O   . LEU A 1 284 ? 152.660 155.435 109.830 1.00 75.08  ? 284 LEU A O   1 
ATOM 2105 C CB  . LEU A 1 284 ? 153.927 158.259 110.161 1.00 75.17  ? 284 LEU A CB  1 
ATOM 2106 C CG  . LEU A 1 284 ? 154.506 159.440 109.382 1.00 75.70  ? 284 LEU A CG  1 
ATOM 2107 C CD1 . LEU A 1 284 ? 153.695 160.697 109.651 1.00 75.13  ? 284 LEU A CD1 1 
ATOM 2108 C CD2 . LEU A 1 284 ? 155.968 159.655 109.743 1.00 74.50  ? 284 LEU A CD2 1 
ATOM 2109 N N   . THR A 1 285 ? 154.006 155.263 111.634 1.00 74.09  ? 285 THR A N   1 
ATOM 2110 C CA  . THR A 1 285 ? 153.237 154.228 112.303 1.00 72.26  ? 285 THR A CA  1 
ATOM 2111 C C   . THR A 1 285 ? 152.798 154.722 113.674 1.00 74.21  ? 285 THR A C   1 
ATOM 2112 O O   . THR A 1 285 ? 153.394 155.636 114.250 1.00 74.05  ? 285 THR A O   1 
ATOM 2113 C CB  . THR A 1 285 ? 154.045 152.936 112.462 1.00 73.56  ? 285 THR A CB  1 
ATOM 2114 O OG1 . THR A 1 285 ? 155.025 153.118 113.491 1.00 75.53  ? 285 THR A OG1 1 
ATOM 2115 C CG2 . THR A 1 285 ? 154.737 152.558 111.159 1.00 73.55  ? 285 THR A CG2 1 
ATOM 2116 N N   . VAL A 1 286 ? 151.743 154.104 114.196 1.00 78.60  ? 286 VAL A N   1 
ATOM 2117 C CA  . VAL A 1 286 ? 151.190 154.456 115.497 1.00 81.16  ? 286 VAL A CA  1 
ATOM 2118 C C   . VAL A 1 286 ? 151.145 153.199 116.359 1.00 85.69  ? 286 VAL A C   1 
ATOM 2119 O O   . VAL A 1 286 ? 150.710 152.136 115.901 1.00 86.40  ? 286 VAL A O   1 
ATOM 2120 C CB  . VAL A 1 286 ? 149.803 155.120 115.361 1.00 81.86  ? 286 VAL A CB  1 
ATOM 2121 C CG1 . VAL A 1 286 ? 148.855 154.293 114.487 1.00 82.43  ? 286 VAL A CG1 1 
ATOM 2122 C CG2 . VAL A 1 286 ? 149.198 155.417 116.729 1.00 80.01  ? 286 VAL A CG2 1 
ATOM 2123 N N   . THR A 1 287 ? 151.639 153.313 117.588 1.00 100.84 ? 287 THR A N   1 
ATOM 2124 C CA  . THR A 1 287 ? 151.658 152.210 118.539 1.00 98.76  ? 287 THR A CA  1 
ATOM 2125 C C   . THR A 1 287 ? 150.553 152.425 119.565 1.00 96.06  ? 287 THR A C   1 
ATOM 2126 O O   . THR A 1 287 ? 150.473 153.492 120.183 1.00 93.69  ? 287 THR A O   1 
ATOM 2127 C CB  . THR A 1 287 ? 153.018 152.104 119.231 1.00 95.55  ? 287 THR A CB  1 
ATOM 2128 O OG1 . THR A 1 287 ? 154.062 152.169 118.251 1.00 93.82  ? 287 THR A OG1 1 
ATOM 2129 C CG2 . THR A 1 287 ? 153.126 150.796 120.001 1.00 92.90  ? 287 THR A CG2 1 
ATOM 2130 N N   . ILE A 1 288 ? 149.705 151.415 119.740 1.00 97.95  ? 288 ILE A N   1 
ATOM 2131 C CA  . ILE A 1 288 ? 148.580 151.470 120.665 1.00 98.97  ? 288 ILE A CA  1 
ATOM 2132 C C   . ILE A 1 288 ? 148.700 150.310 121.645 1.00 99.76  ? 288 ILE A C   1 
ATOM 2133 O O   . ILE A 1 288 ? 149.007 149.179 121.253 1.00 96.84  ? 288 ILE A O   1 
ATOM 2134 C CB  . ILE A 1 288 ? 147.230 151.452 119.913 1.00 101.95 ? 288 ILE A CB  1 
ATOM 2135 C CG1 . ILE A 1 288 ? 147.087 152.721 119.070 1.00 101.99 ? 288 ILE A CG1 1 
ATOM 2136 C CG2 . ILE A 1 288 ? 146.046 151.333 120.864 1.00 99.86  ? 288 ILE A CG2 1 
ATOM 2137 C CD1 . ILE A 1 288 ? 147.148 152.481 117.590 1.00 102.55 ? 288 ILE A CD1 1 
ATOM 2138 N N   . SER A 1 289 ? 148.462 150.609 122.922 1.00 94.53  ? 289 SER A N   1 
ATOM 2139 C CA  . SER A 1 289 ? 148.660 149.677 124.016 1.00 90.59  ? 289 SER A CA  1 
ATOM 2140 C C   . SER A 1 289 ? 147.713 148.479 123.907 1.00 92.32  ? 289 SER A C   1 
ATOM 2141 O O   . SER A 1 289 ? 146.677 148.554 123.242 1.00 89.76  ? 289 SER A O   1 
ATOM 2142 C CB  . SER A 1 289 ? 148.443 150.406 125.344 1.00 90.52  ? 289 SER A CB  1 
ATOM 2143 O OG  . SER A 1 289 ? 149.282 151.544 125.443 1.00 92.21  ? 289 SER A OG  1 
ATOM 2144 N N   . PRO A 1 290 ? 148.062 147.355 124.535 1.00 82.36  ? 290 PRO A N   1 
ATOM 2145 C CA  . PRO A 1 290 ? 147.150 146.195 124.570 1.00 77.37  ? 290 PRO A CA  1 
ATOM 2146 C C   . PRO A 1 290 ? 145.896 146.499 125.372 1.00 76.19  ? 290 PRO A C   1 
ATOM 2147 O O   . PRO A 1 290 ? 145.819 147.534 126.050 1.00 76.14  ? 290 PRO A O   1 
ATOM 2148 C CB  . PRO A 1 290 ? 147.995 145.102 125.249 1.00 77.35  ? 290 PRO A CB  1 
ATOM 2149 C CG  . PRO A 1 290 ? 149.395 145.530 125.085 1.00 77.27  ? 290 PRO A CG  1 
ATOM 2150 C CD  . PRO A 1 290 ? 149.387 147.019 125.089 1.00 79.38  ? 290 PRO A CD  1 
ATOM 2151 N N   . PRO A 1 291 ? 144.874 145.626 125.317 1.00 70.05  ? 291 PRO A N   1 
ATOM 2152 C CA  . PRO A 1 291 ? 143.699 145.847 126.167 1.00 72.82  ? 291 PRO A CA  1 
ATOM 2153 C C   . PRO A 1 291 ? 144.025 145.657 127.637 1.00 74.33  ? 291 PRO A C   1 
ATOM 2154 O O   . PRO A 1 291 ? 144.188 144.529 128.109 1.00 73.72  ? 291 PRO A O   1 
ATOM 2155 C CB  . PRO A 1 291 ? 142.699 144.792 125.675 1.00 69.50  ? 291 PRO A CB  1 
ATOM 2156 C CG  . PRO A 1 291 ? 143.512 143.796 124.934 1.00 66.35  ? 291 PRO A CG  1 
ATOM 2157 C CD  . PRO A 1 291 ? 144.617 144.577 124.315 1.00 67.48  ? 291 PRO A CD  1 
ATOM 2158 N N   . LEU A 1 292 ? 144.119 146.767 128.370 1.00 77.06  ? 292 LEU A N   1 
ATOM 2159 C CA  . LEU A 1 292 ? 144.441 146.725 129.792 1.00 79.60  ? 292 LEU A CA  1 
ATOM 2160 C C   . LEU A 1 292 ? 143.178 146.711 130.647 1.00 80.70  ? 292 LEU A C   1 
ATOM 2161 O O   . LEU A 1 292 ? 142.962 145.773 131.420 1.00 80.15  ? 292 LEU A O   1 
ATOM 2162 C CB  . LEU A 1 292 ? 145.331 147.917 130.167 1.00 78.43  ? 292 LEU A CB  1 
ATOM 2163 C CG  . LEU A 1 292 ? 146.409 148.325 129.162 1.00 80.24  ? 292 LEU A CG  1 
ATOM 2164 C CD1 . LEU A 1 292 ? 146.995 149.684 129.512 1.00 80.59  ? 292 LEU A CD1 1 
ATOM 2165 C CD2 . LEU A 1 292 ? 147.502 147.269 129.080 1.00 79.18  ? 292 LEU A CD2 1 
ATOM 2166 N N   . ALA A 1 293 ? 142.340 147.745 130.498 1.00 78.46  ? 293 ALA A N   1 
ATOM 2167 C CA  . ALA A 1 293 ? 141.116 147.939 131.286 1.00 77.52  ? 293 ALA A CA  1 
ATOM 2168 C C   . ALA A 1 293 ? 141.406 147.903 132.784 1.00 75.67  ? 293 ALA A C   1 
ATOM 2169 O O   . ALA A 1 293 ? 140.634 147.348 133.569 1.00 76.31  ? 293 ALA A O   1 
ATOM 2170 C CB  . ALA A 1 293 ? 140.040 146.920 130.908 1.00 71.94  ? 293 ALA A CB  1 
ATOM 2171 N N   . HIS A 1 294 ? 142.541 148.506 133.165 1.00 76.37  ? 294 HIS A N   1 
ATOM 2172 C CA  . HIS A 1 294 ? 143.120 148.574 134.510 1.00 73.91  ? 294 HIS A CA  1 
ATOM 2173 C C   . HIS A 1 294 ? 143.056 147.257 135.285 1.00 74.61  ? 294 HIS A C   1 
ATOM 2174 O O   . HIS A 1 294 ? 142.873 147.257 136.507 1.00 76.43  ? 294 HIS A O   1 
ATOM 2175 C CB  . HIS A 1 294 ? 142.481 149.712 135.329 1.00 76.34  ? 294 HIS A CB  1 
ATOM 2176 C CG  . HIS A 1 294 ? 141.003 149.580 135.535 1.00 76.34  ? 294 HIS A CG  1 
ATOM 2177 N ND1 . HIS A 1 294 ? 140.081 150.149 134.683 1.00 76.94  ? 294 HIS A ND1 1 
ATOM 2178 C CD2 . HIS A 1 294 ? 140.287 148.950 136.496 1.00 77.37  ? 294 HIS A CD2 1 
ATOM 2179 C CE1 . HIS A 1 294 ? 138.861 149.871 135.108 1.00 75.98  ? 294 HIS A CE1 1 
ATOM 2180 N NE2 . HIS A 1 294 ? 138.958 149.145 136.207 1.00 77.96  ? 294 HIS A NE2 1 
ATOM 2181 N N   . THR A 1 295 ? 143.231 146.131 134.587 1.00 79.63  ? 295 THR A N   1 
ATOM 2182 C CA  . THR A 1 295 ? 143.278 144.829 135.239 1.00 80.14  ? 295 THR A CA  1 
ATOM 2183 C C   . THR A 1 295 ? 144.321 143.893 134.644 1.00 78.79  ? 295 THR A C   1 
ATOM 2184 O O   . THR A 1 295 ? 144.376 142.728 135.051 1.00 77.40  ? 295 THR A O   1 
ATOM 2185 C CB  . THR A 1 295 ? 141.900 144.146 135.195 1.00 80.15  ? 295 THR A CB  1 
ATOM 2186 O OG1 . THR A 1 295 ? 141.953 142.909 135.917 1.00 84.13  ? 295 THR A OG1 1 
ATOM 2187 C CG2 . THR A 1 295 ? 141.485 143.869 133.763 1.00 77.69  ? 295 THR A CG2 1 
ATOM 2188 N N   . GLY A 1 296 ? 145.142 144.353 133.704 1.00 76.97  ? 296 GLY A N   1 
ATOM 2189 C CA  . GLY A 1 296 ? 146.182 143.533 133.131 1.00 77.89  ? 296 GLY A CA  1 
ATOM 2190 C C   . GLY A 1 296 ? 145.745 142.845 131.854 1.00 76.80  ? 296 GLY A C   1 
ATOM 2191 O O   . GLY A 1 296 ? 144.703 142.184 131.804 1.00 76.60  ? 296 GLY A O   1 
ATOM 2192 N N   . PRO A 1 297 ? 146.530 143.004 130.788 1.00 78.43  ? 297 PRO A N   1 
ATOM 2193 C CA  . PRO A 1 297 ? 146.215 142.316 129.531 1.00 78.07  ? 297 PRO A CA  1 
ATOM 2194 C C   . PRO A 1 297 ? 146.375 140.810 129.651 1.00 78.81  ? 297 PRO A C   1 
ATOM 2195 O O   . PRO A 1 297 ? 147.233 140.304 130.380 1.00 79.60  ? 297 PRO A O   1 
ATOM 2196 C CB  . PRO A 1 297 ? 147.224 142.907 128.539 1.00 77.52  ? 297 PRO A CB  1 
ATOM 2197 C CG  . PRO A 1 297 ? 148.349 143.391 129.388 1.00 77.64  ? 297 PRO A CG  1 
ATOM 2198 C CD  . PRO A 1 297 ? 147.724 143.858 130.669 1.00 78.17  ? 297 PRO A CD  1 
ATOM 2199 N N   . GLY A 1 298 ? 145.534 140.093 128.912 1.00 73.38  ? 298 GLY A N   1 
ATOM 2200 C CA  . GLY A 1 298 ? 145.538 138.652 128.938 1.00 72.94  ? 298 GLY A CA  1 
ATOM 2201 C C   . GLY A 1 298 ? 145.581 138.051 127.548 1.00 73.47  ? 298 GLY A C   1 
ATOM 2202 O O   . GLY A 1 298 ? 145.973 138.699 126.573 1.00 75.50  ? 298 GLY A O   1 
ATOM 2203 N N   . PRO A 1 299 ? 145.159 136.791 127.430 1.00 67.12  ? 299 PRO A N   1 
ATOM 2204 C CA  . PRO A 1 299 ? 145.186 136.107 126.133 1.00 63.83  ? 299 PRO A CA  1 
ATOM 2205 C C   . PRO A 1 299 ? 143.946 136.369 125.284 1.00 59.13  ? 299 PRO A C   1 
ATOM 2206 O O   . PRO A 1 299 ? 142.829 135.969 125.625 1.00 65.56  ? 299 PRO A O   1 
ATOM 2207 C CB  . PRO A 1 299 ? 145.314 134.635 126.538 1.00 59.35  ? 299 PRO A CB  1 
ATOM 2208 C CG  . PRO A 1 299 ? 144.530 134.570 127.909 1.00 59.16  ? 299 PRO A CG  1 
ATOM 2209 C CD  . PRO A 1 299 ? 144.293 136.034 128.355 1.00 63.62  ? 299 PRO A CD  1 
ATOM 2210 N N   . VAL A 1 300 ? 144.154 137.031 124.148 1.00 50.76  ? 300 VAL A N   1 
ATOM 2211 C CA  . VAL A 1 300 ? 143.053 137.321 123.242 1.00 44.59  ? 300 VAL A CA  1 
ATOM 2212 C C   . VAL A 1 300 ? 142.741 136.015 122.524 1.00 49.25  ? 300 VAL A C   1 
ATOM 2213 O O   . VAL A 1 300 ? 143.457 135.605 121.600 1.00 48.84  ? 300 VAL A O   1 
ATOM 2214 C CB  . VAL A 1 300 ? 143.405 138.456 122.263 1.00 39.29  ? 300 VAL A CB  1 
ATOM 2215 C CG1 . VAL A 1 300 ? 142.419 138.495 121.109 1.00 43.21  ? 300 VAL A CG1 1 
ATOM 2216 C CG2 . VAL A 1 300 ? 143.457 139.787 122.986 1.00 42.39  ? 300 VAL A CG2 1 
ATOM 2217 N N   . LEU A 1 301 ? 141.702 135.325 122.985 1.00 49.30  ? 301 LEU A N   1 
ATOM 2218 C CA  . LEU A 1 301 ? 141.415 133.966 122.534 1.00 39.13  ? 301 LEU A CA  1 
ATOM 2219 C C   . LEU A 1 301 ? 140.553 134.020 121.278 1.00 28.10  ? 301 LEU A C   1 
ATOM 2220 O O   . LEU A 1 301 ? 139.360 134.325 121.325 1.00 30.83  ? 301 LEU A O   1 
ATOM 2221 C CB  . LEU A 1 301 ? 140.768 133.154 123.657 1.00 38.74  ? 301 LEU A CB  1 
ATOM 2222 C CG  . LEU A 1 301 ? 139.485 133.538 124.408 1.00 29.57  ? 301 LEU A CG  1 
ATOM 2223 C CD1 . LEU A 1 301 ? 138.805 132.279 124.910 1.00 32.05  ? 301 LEU A CD1 1 
ATOM 2224 C CD2 . LEU A 1 301 ? 139.757 134.487 125.566 1.00 34.26  ? 301 LEU A CD2 1 
ATOM 2225 N N   . VAL A 1 302 ? 141.174 133.753 120.137 1.00 13.17  ? 302 VAL A N   1 
ATOM 2226 C CA  . VAL A 1 302 ? 140.476 133.653 118.871 1.00 6.96   ? 302 VAL A CA  1 
ATOM 2227 C C   . VAL A 1 302 ? 140.545 132.198 118.426 1.00 14.29  ? 302 VAL A C   1 
ATOM 2228 O O   . VAL A 1 302 ? 141.236 131.379 119.028 1.00 23.89  ? 302 VAL A O   1 
ATOM 2229 C CB  . VAL A 1 302 ? 141.068 134.603 117.816 1.00 5.53   ? 302 VAL A CB  1 
ATOM 2230 C CG1 . VAL A 1 302 ? 141.332 135.959 118.436 1.00 21.89  ? 302 VAL A CG1 1 
ATOM 2231 C CG2 . VAL A 1 302 ? 142.348 134.038 117.265 1.00 12.87  ? 302 VAL A CG2 1 
ATOM 2232 N N   . ARG A 1 303 ? 139.807 131.869 117.369 1.00 12.25  ? 303 ARG A N   1 
ATOM 2233 C CA  . ARG A 1 303 ? 139.875 130.511 116.843 1.00 22.67  ? 303 ARG A CA  1 
ATOM 2234 C C   . ARG A 1 303 ? 139.627 130.508 115.342 1.00 21.13  ? 303 ARG A C   1 
ATOM 2235 O O   . ARG A 1 303 ? 138.673 131.122 114.860 1.00 28.70  ? 303 ARG A O   1 
ATOM 2236 C CB  . ARG A 1 303 ? 138.893 129.589 117.575 1.00 8.62   ? 303 ARG A CB  1 
ATOM 2237 C CG  . ARG A 1 303 ? 137.462 130.064 117.647 1.00 11.48  ? 303 ARG A CG  1 
ATOM 2238 C CD  . ARG A 1 303 ? 136.681 129.243 118.674 1.00 25.47  ? 303 ARG A CD  1 
ATOM 2239 N NE  . ARG A 1 303 ? 136.863 127.797 118.559 1.00 41.63  ? 303 ARG A NE  1 
ATOM 2240 C CZ  . ARG A 1 303 ? 136.486 127.043 117.533 1.00 42.33  ? 303 ARG A CZ  1 
ATOM 2241 N NH1 . ARG A 1 303 ? 135.816 127.544 116.509 1.00 30.38  ? 303 ARG A NH1 1 
ATOM 2242 N NH2 . ARG A 1 303 ? 136.769 125.744 117.547 1.00 26.63  ? 303 ARG A NH2 1 
ATOM 2243 N N   . LEU A 1 304 ? 140.497 129.816 114.614 1.00 26.44  ? 304 LEU A N   1 
ATOM 2244 C CA  . LEU A 1 304 ? 140.477 129.795 113.158 1.00 19.89  ? 304 LEU A CA  1 
ATOM 2245 C C   . LEU A 1 304 ? 139.665 128.608 112.664 1.00 18.25  ? 304 LEU A C   1 
ATOM 2246 O O   . LEU A 1 304 ? 139.942 127.463 113.032 1.00 24.98  ? 304 LEU A O   1 
ATOM 2247 C CB  . LEU A 1 304 ? 141.900 129.721 112.600 1.00 27.22  ? 304 LEU A CB  1 
ATOM 2248 C CG  . LEU A 1 304 ? 142.071 129.717 111.077 1.00 20.22  ? 304 LEU A CG  1 
ATOM 2249 C CD1 . LEU A 1 304 ? 141.205 130.770 110.413 1.00 19.42  ? 304 LEU A CD1 1 
ATOM 2250 C CD2 . LEU A 1 304 ? 143.523 129.921 110.703 1.00 13.76  ? 304 LEU A CD2 1 
ATOM 2251 N N   . ILE A 1 305 ? 138.677 128.885 111.824 1.00 11.63  ? 305 ILE A N   1 
ATOM 2252 C CA  . ILE A 1 305 ? 137.884 127.862 111.159 1.00 16.85  ? 305 ILE A CA  1 
ATOM 2253 C C   . ILE A 1 305 ? 138.121 128.016 109.665 1.00 14.52  ? 305 ILE A C   1 
ATOM 2254 O O   . ILE A 1 305 ? 137.762 129.040 109.073 1.00 25.86  ? 305 ILE A O   1 
ATOM 2255 C CB  . ILE A 1 305 ? 136.394 127.981 111.502 1.00 5.68   ? 305 ILE A CB  1 
ATOM 2256 C CG1 . ILE A 1 305 ? 136.168 127.743 112.998 1.00 0.98   ? 305 ILE A CG1 1 
ATOM 2257 C CG2 . ILE A 1 305 ? 135.580 127.022 110.646 1.00 23.01  ? 305 ILE A CG2 1 
ATOM 2258 C CD1 . ILE A 1 305 ? 134.735 127.443 113.363 1.00 8.51   ? 305 ILE A CD1 1 
ATOM 2259 N N   . SER A 1 306 ? 138.724 127.006 109.051 1.00 27.37  ? 306 SER A N   1 
ATOM 2260 C CA  . SER A 1 306 ? 139.028 127.034 107.630 1.00 26.88  ? 306 SER A CA  1 
ATOM 2261 C C   . SER A 1 306 ? 138.615 125.717 106.996 1.00 34.72  ? 306 SER A C   1 
ATOM 2262 O O   . SER A 1 306 ? 138.523 124.687 107.668 1.00 34.42  ? 306 SER A O   1 
ATOM 2263 C CB  . SER A 1 306 ? 140.516 127.289 107.374 1.00 39.25  ? 306 SER A CB  1 
ATOM 2264 O OG  . SER A 1 306 ? 140.972 128.406 108.115 1.00 46.60  ? 306 SER A OG  1 
ATOM 2265 N N   . TYR A 1 307 ? 138.357 125.765 105.689 1.00 44.60  ? 307 TYR A N   1 
ATOM 2266 C CA  . TYR A 1 307 ? 137.927 124.564 104.982 1.00 46.26  ? 307 TYR A CA  1 
ATOM 2267 C C   . TYR A 1 307 ? 139.072 123.571 104.833 1.00 52.34  ? 307 TYR A C   1 
ATOM 2268 O O   . TYR A 1 307 ? 138.892 122.369 105.047 1.00 56.58  ? 307 TYR A O   1 
ATOM 2269 C CB  . TYR A 1 307 ? 137.353 124.934 103.616 1.00 46.75  ? 307 TYR A CB  1 
ATOM 2270 C CG  . TYR A 1 307 ? 136.447 123.871 103.050 1.00 46.82  ? 307 TYR A CG  1 
ATOM 2271 C CD1 . TYR A 1 307 ? 135.786 122.981 103.887 1.00 46.71  ? 307 TYR A CD1 1 
ATOM 2272 C CD2 . TYR A 1 307 ? 136.257 123.751 101.682 1.00 47.67  ? 307 TYR A CD2 1 
ATOM 2273 C CE1 . TYR A 1 307 ? 134.960 122.005 103.379 1.00 49.34  ? 307 TYR A CE1 1 
ATOM 2274 C CE2 . TYR A 1 307 ? 135.433 122.776 101.163 1.00 48.69  ? 307 TYR A CE2 1 
ATOM 2275 C CZ  . TYR A 1 307 ? 134.787 121.906 102.016 1.00 48.72  ? 307 TYR A CZ  1 
ATOM 2276 O OH  . TYR A 1 307 ? 133.962 120.932 101.504 1.00 43.56  ? 307 TYR A OH  1 
ATOM 2277 N N   . ASP A 1 308 ? 140.256 124.055 104.461 1.00 54.67  ? 308 ASP A N   1 
ATOM 2278 C CA  . ASP A 1 308 ? 141.425 123.208 104.273 1.00 51.44  ? 308 ASP A CA  1 
ATOM 2279 C C   . ASP A 1 308 ? 142.637 123.881 104.901 1.00 52.68  ? 308 ASP A C   1 
ATOM 2280 O O   . ASP A 1 308 ? 142.578 125.029 105.349 1.00 49.66  ? 308 ASP A O   1 
ATOM 2281 C CB  . ASP A 1 308 ? 141.696 122.927 102.787 1.00 49.66  ? 308 ASP A CB  1 
ATOM 2282 C CG  . ASP A 1 308 ? 140.467 122.443 102.046 1.00 49.33  ? 308 ASP A CG  1 
ATOM 2283 O OD1 . ASP A 1 308 ? 139.857 121.446 102.486 1.00 49.23  ? 308 ASP A OD1 1 
ATOM 2284 O OD2 . ASP A 1 308 ? 140.112 123.059 101.019 1.00 46.05  ? 308 ASP A OD2 1 
ATOM 2285 N N   . LEU A 1 309 ? 143.747 123.148 104.933 1.00 51.05  ? 309 LEU A N   1 
ATOM 2286 C CA  . LEU A 1 309 ? 145.018 123.724 105.351 1.00 57.33  ? 309 LEU A CA  1 
ATOM 2287 C C   . LEU A 1 309 ? 145.557 124.603 104.229 1.00 59.32  ? 309 LEU A C   1 
ATOM 2288 O O   . LEU A 1 309 ? 145.699 124.147 103.090 1.00 58.64  ? 309 LEU A O   1 
ATOM 2289 C CB  . LEU A 1 309 ? 146.012 122.621 105.702 1.00 59.60  ? 309 LEU A CB  1 
ATOM 2290 C CG  . LEU A 1 309 ? 145.865 121.935 107.063 1.00 58.20  ? 309 LEU A CG  1 
ATOM 2291 C CD1 . LEU A 1 309 ? 146.907 120.844 107.216 1.00 56.19  ? 309 LEU A CD1 1 
ATOM 2292 C CD2 . LEU A 1 309 ? 145.990 122.941 108.193 1.00 57.43  ? 309 LEU A CD2 1 
ATOM 2293 N N   . ARG A 1 310 ? 145.854 125.859 104.546 1.00 61.23  ? 310 ARG A N   1 
ATOM 2294 C CA  . ARG A 1 310 ? 146.257 126.837 103.551 1.00 50.91  ? 310 ARG A CA  1 
ATOM 2295 C C   . ARG A 1 310 ? 147.776 127.002 103.548 1.00 54.95  ? 310 ARG A C   1 
ATOM 2296 O O   . ARG A 1 310 ? 148.489 126.465 104.398 1.00 58.18  ? 310 ARG A O   1 
ATOM 2297 C CB  . ARG A 1 310 ? 145.547 128.166 103.806 1.00 56.52  ? 310 ARG A CB  1 
ATOM 2298 C CG  . ARG A 1 310 ? 144.037 128.030 103.887 1.00 57.83  ? 310 ARG A CG  1 
ATOM 2299 C CD  . ARG A 1 310 ? 143.362 128.602 102.657 1.00 58.45  ? 310 ARG A CD  1 
ATOM 2300 N NE  . ARG A 1 310 ? 141.917 128.420 102.703 1.00 53.05  ? 310 ARG A NE  1 
ATOM 2301 C CZ  . ARG A 1 310 ? 141.150 128.263 101.634 1.00 62.00  ? 310 ARG A CZ  1 
ATOM 2302 N NH1 . ARG A 1 310 ? 141.657 128.267 100.412 1.00 63.79  ? 310 ARG A NH1 1 
ATOM 2303 N NH2 . ARG A 1 310 ? 139.841 128.096 101.794 1.00 67.36  ? 310 ARG A NH2 1 
ATOM 2304 N N   . GLU A 1 311 ? 148.270 127.763 102.574 1.00 64.55  ? 311 GLU A N   1 
ATOM 2305 C CA  . GLU A 1 311 ? 149.708 127.888 102.364 1.00 70.64  ? 311 GLU A CA  1 
ATOM 2306 C C   . GLU A 1 311 ? 150.346 128.721 103.467 1.00 70.86  ? 311 GLU A C   1 
ATOM 2307 O O   . GLU A 1 311 ? 149.867 129.810 103.797 1.00 67.60  ? 311 GLU A O   1 
ATOM 2308 C CB  . GLU A 1 311 ? 149.987 128.513 100.997 1.00 67.88  ? 311 GLU A CB  1 
ATOM 2309 C CG  . GLU A 1 311 ? 151.366 129.140 100.854 1.00 67.86  ? 311 GLU A CG  1 
ATOM 2310 C CD  . GLU A 1 311 ? 152.483 128.122 100.965 1.00 68.06  ? 311 GLU A CD  1 
ATOM 2311 O OE1 . GLU A 1 311 ? 152.325 127.006 100.431 1.00 71.60  ? 311 GLU A OE1 1 
ATOM 2312 O OE2 . GLU A 1 311 ? 153.515 128.436 101.593 1.00 67.06  ? 311 GLU A OE2 1 
ATOM 2313 N N   . GLY A 1 312 ? 151.434 128.204 104.035 1.00 69.13  ? 312 GLY A N   1 
ATOM 2314 C CA  . GLY A 1 312 ? 152.139 128.907 105.087 1.00 71.16  ? 312 GLY A CA  1 
ATOM 2315 C C   . GLY A 1 312 ? 151.390 128.989 106.393 1.00 70.24  ? 312 GLY A C   1 
ATOM 2316 O O   . GLY A 1 312 ? 151.735 129.810 107.245 1.00 69.96  ? 312 GLY A O   1 
ATOM 2317 N N   . GLN A 1 313 ? 150.375 128.147 106.581 1.00 65.31  ? 313 GLN A N   1 
ATOM 2318 C CA  . GLN A 1 313 ? 149.518 128.211 107.752 1.00 60.92  ? 313 GLN A CA  1 
ATOM 2319 C C   . GLN A 1 313 ? 149.696 127.041 108.706 1.00 71.22  ? 313 GLN A C   1 
ATOM 2320 O O   . GLN A 1 313 ? 149.678 127.256 109.921 1.00 77.66  ? 313 GLN A O   1 
ATOM 2321 C CB  . GLN A 1 313 ? 148.046 128.303 107.316 1.00 61.34  ? 313 GLN A CB  1 
ATOM 2322 C CG  . GLN A 1 313 ? 147.017 128.175 108.420 1.00 64.23  ? 313 GLN A CG  1 
ATOM 2323 C CD  . GLN A 1 313 ? 146.166 126.938 108.273 1.00 70.04  ? 313 GLN A CD  1 
ATOM 2324 O OE1 . GLN A 1 313 ? 145.786 126.562 107.165 1.00 79.79  ? 313 GLN A OE1 1 
ATOM 2325 N NE2 . GLN A 1 313 ? 145.853 126.298 109.392 1.00 68.16  ? 313 GLN A NE2 1 
ATOM 2326 N N   . ASP A 1 314 ? 149.923 125.828 108.204 1.00 74.25  ? 314 ASP A N   1 
ATOM 2327 C CA  . ASP A 1 314 ? 150.101 124.651 109.045 1.00 74.66  ? 314 ASP A CA  1 
ATOM 2328 C C   . ASP A 1 314 ? 151.524 124.503 109.579 1.00 75.07  ? 314 ASP A C   1 
ATOM 2329 O O   . ASP A 1 314 ? 151.886 123.419 110.045 1.00 79.68  ? 314 ASP A O   1 
ATOM 2330 C CB  . ASP A 1 314 ? 149.705 123.389 108.273 1.00 74.14  ? 314 ASP A CB  1 
ATOM 2331 C CG  . ASP A 1 314 ? 150.275 123.360 106.867 1.00 78.87  ? 314 ASP A CG  1 
ATOM 2332 O OD1 . ASP A 1 314 ? 150.932 124.343 106.466 1.00 80.43  ? 314 ASP A OD1 1 
ATOM 2333 O OD2 . ASP A 1 314 ? 150.061 122.354 106.159 1.00 79.05  ? 314 ASP A OD2 1 
ATOM 2334 N N   . SER A 1 315 ? 152.331 125.560 109.527 1.00 69.95  ? 315 SER A N   1 
ATOM 2335 C CA  . SER A 1 315 ? 153.712 125.505 109.984 1.00 68.18  ? 315 SER A CA  1 
ATOM 2336 C C   . SER A 1 315 ? 153.767 125.720 111.497 1.00 69.94  ? 315 SER A C   1 
ATOM 2337 O O   . SER A 1 315 ? 152.749 125.690 112.194 1.00 71.39  ? 315 SER A O   1 
ATOM 2338 C CB  . SER A 1 315 ? 154.557 126.522 109.224 1.00 66.94  ? 315 SER A CB  1 
ATOM 2339 O OG  . SER A 1 315 ? 155.682 126.926 109.984 1.00 73.87  ? 315 SER A OG  1 
ATOM 2340 N N   . GLU A 1 316 ? 154.976 125.937 112.024 1.00 73.97  ? 316 GLU A N   1 
ATOM 2341 C CA  . GLU A 1 316 ? 155.167 126.047 113.466 1.00 75.06  ? 316 GLU A CA  1 
ATOM 2342 C C   . GLU A 1 316 ? 154.650 127.363 114.036 1.00 74.12  ? 316 GLU A C   1 
ATOM 2343 O O   . GLU A 1 316 ? 154.306 127.412 115.224 1.00 73.05  ? 316 GLU A O   1 
ATOM 2344 C CB  . GLU A 1 316 ? 156.649 125.882 113.810 1.00 77.80  ? 316 GLU A CB  1 
ATOM 2345 C CG  . GLU A 1 316 ? 156.915 125.444 115.243 1.00 80.96  ? 316 GLU A CG  1 
ATOM 2346 C CD  . GLU A 1 316 ? 157.279 126.604 116.149 1.00 74.22  ? 316 GLU A CD  1 
ATOM 2347 O OE1 . GLU A 1 316 ? 157.717 127.651 115.629 1.00 74.32  ? 316 GLU A OE1 1 
ATOM 2348 O OE2 . GLU A 1 316 ? 157.127 126.468 117.381 1.00 74.11  ? 316 GLU A OE2 1 
ATOM 2349 N N   . GLU A 1 317 ? 154.579 128.422 113.221 1.00 78.26  ? 317 GLU A N   1 
ATOM 2350 C CA  . GLU A 1 317 ? 154.169 129.728 113.728 1.00 72.99  ? 317 GLU A CA  1 
ATOM 2351 C C   . GLU A 1 317 ? 152.712 129.735 114.171 1.00 72.97  ? 317 GLU A C   1 
ATOM 2352 O O   . GLU A 1 317 ? 152.345 130.502 115.068 1.00 78.41  ? 317 GLU A O   1 
ATOM 2353 C CB  . GLU A 1 317 ? 154.411 130.810 112.674 1.00 72.78  ? 317 GLU A CB  1 
ATOM 2354 C CG  . GLU A 1 317 ? 153.676 130.604 111.361 1.00 72.49  ? 317 GLU A CG  1 
ATOM 2355 C CD  . GLU A 1 317 ? 154.521 129.895 110.323 1.00 73.00  ? 317 GLU A CD  1 
ATOM 2356 O OE1 . GLU A 1 317 ? 155.645 129.468 110.659 1.00 78.74  ? 317 GLU A OE1 1 
ATOM 2357 O OE2 . GLU A 1 317 ? 154.063 129.775 109.168 1.00 74.21  ? 317 GLU A OE2 1 
ATOM 2358 N N   . LEU A 1 318 ? 151.872 128.898 113.567 1.00 56.57  ? 318 LEU A N   1 
ATOM 2359 C CA  . LEU A 1 318 ? 150.524 128.699 114.078 1.00 56.94  ? 318 LEU A CA  1 
ATOM 2360 C C   . LEU A 1 318 ? 150.454 127.555 115.078 1.00 58.00  ? 318 LEU A C   1 
ATOM 2361 O O   . LEU A 1 318 ? 149.624 127.591 115.995 1.00 62.03  ? 318 LEU A O   1 
ATOM 2362 C CB  . LEU A 1 318 ? 149.551 128.444 112.923 1.00 56.96  ? 318 LEU A CB  1 
ATOM 2363 C CG  . LEU A 1 318 ? 148.063 128.326 113.262 1.00 49.50  ? 318 LEU A CG  1 
ATOM 2364 C CD1 . LEU A 1 318 ? 147.501 129.664 113.688 1.00 49.37  ? 318 LEU A CD1 1 
ATOM 2365 C CD2 . LEU A 1 318 ? 147.285 127.779 112.087 1.00 51.55  ? 318 LEU A CD2 1 
ATOM 2366 N N   . SER A 1 319 ? 151.325 126.553 114.942 1.00 57.10  ? 319 SER A N   1 
ATOM 2367 C CA  . SER A 1 319 ? 151.299 125.406 115.840 1.00 61.12  ? 319 SER A CA  1 
ATOM 2368 C C   . SER A 1 319 ? 151.812 125.730 117.236 1.00 60.50  ? 319 SER A C   1 
ATOM 2369 O O   . SER A 1 319 ? 151.603 124.927 118.151 1.00 61.56  ? 319 SER A O   1 
ATOM 2370 C CB  . SER A 1 319 ? 152.117 124.258 115.249 1.00 65.59  ? 319 SER A CB  1 
ATOM 2371 O OG  . SER A 1 319 ? 153.458 124.306 115.702 1.00 67.04  ? 319 SER A OG  1 
ATOM 2372 N N   . SER A 1 320 ? 152.466 126.872 117.426 1.00 62.14  ? 320 SER A N   1 
ATOM 2373 C CA  . SER A 1 320 ? 153.030 127.232 118.719 1.00 62.69  ? 320 SER A CA  1 
ATOM 2374 C C   . SER A 1 320 ? 152.084 128.050 119.592 1.00 58.70  ? 320 SER A C   1 
ATOM 2375 O O   . SER A 1 320 ? 152.497 128.495 120.667 1.00 58.94  ? 320 SER A O   1 
ATOM 2376 C CB  . SER A 1 320 ? 154.336 128.008 118.524 1.00 60.82  ? 320 SER A CB  1 
ATOM 2377 O OG  . SER A 1 320 ? 154.163 129.073 117.607 1.00 58.25  ? 320 SER A OG  1 
ATOM 2378 N N   . LEU A 1 321 ? 150.837 128.267 119.170 1.00 50.55  ? 321 LEU A N   1 
ATOM 2379 C CA  . LEU A 1 321 ? 149.929 129.141 119.905 1.00 48.59  ? 321 LEU A CA  1 
ATOM 2380 C C   . LEU A 1 321 ? 148.623 128.475 120.322 1.00 48.05  ? 321 LEU A C   1 
ATOM 2381 O O   . LEU A 1 321 ? 147.710 129.176 120.772 1.00 51.22  ? 321 LEU A O   1 
ATOM 2382 C CB  . LEU A 1 321 ? 149.610 130.397 119.087 1.00 47.80  ? 321 LEU A CB  1 
ATOM 2383 C CG  . LEU A 1 321 ? 150.697 130.999 118.199 1.00 49.80  ? 321 LEU A CG  1 
ATOM 2384 C CD1 . LEU A 1 321 ? 150.089 132.033 117.276 1.00 47.76  ? 321 LEU A CD1 1 
ATOM 2385 C CD2 . LEU A 1 321 ? 151.795 131.619 119.044 1.00 48.70  ? 321 LEU A CD2 1 
ATOM 2386 N N   . ILE A 1 322 ? 148.496 127.160 120.199 1.00 41.01  ? 322 ILE A N   1 
ATOM 2387 C CA  . ILE A 1 322 ? 147.268 126.491 120.615 1.00 40.73  ? 322 ILE A CA  1 
ATOM 2388 C C   . ILE A 1 322 ? 147.260 126.376 122.133 1.00 48.11  ? 322 ILE A C   1 
ATOM 2389 O O   . ILE A 1 322 ? 148.209 125.859 122.734 1.00 45.95  ? 322 ILE A O   1 
ATOM 2390 C CB  . ILE A 1 322 ? 147.139 125.112 119.950 1.00 47.84  ? 322 ILE A CB  1 
ATOM 2391 C CG1 . ILE A 1 322 ? 146.715 125.269 118.487 1.00 34.85  ? 322 ILE A CG1 1 
ATOM 2392 C CG2 . ILE A 1 322 ? 146.139 124.239 120.709 1.00 44.65  ? 322 ILE A CG2 1 
ATOM 2393 C CD1 . ILE A 1 322 ? 146.208 123.992 117.838 1.00 35.77  ? 322 ILE A CD1 1 
ATOM 2394 N N   . LYS A 1 323 ? 146.194 126.869 122.759 1.00 58.11  ? 323 LYS A N   1 
ATOM 2395 C CA  . LYS A 1 323 ? 146.069 126.794 124.207 1.00 64.68  ? 323 LYS A CA  1 
ATOM 2396 C C   . LYS A 1 323 ? 145.597 125.410 124.630 1.00 65.85  ? 323 LYS A C   1 
ATOM 2397 O O   . LYS A 1 323 ? 144.696 124.829 124.017 1.00 63.86  ? 323 LYS A O   1 
ATOM 2398 C CB  . LYS A 1 323 ? 145.099 127.857 124.720 1.00 62.16  ? 323 LYS A CB  1 
ATOM 2399 C CG  . LYS A 1 323 ? 145.235 128.144 126.207 1.00 61.31  ? 323 LYS A CG  1 
ATOM 2400 C CD  . LYS A 1 323 ? 146.662 128.532 126.559 1.00 63.96  ? 323 LYS A CD  1 
ATOM 2401 C CE  . LYS A 1 323 ? 146.835 128.708 128.057 1.00 60.95  ? 323 LYS A CE  1 
ATOM 2402 N NZ  . LYS A 1 323 ? 145.619 129.282 128.693 1.00 60.88  ? 323 LYS A NZ  1 
ATOM 2403 N N   . SER A 1 324 ? 146.212 124.885 125.685 1.00 73.01  ? 324 SER A N   1 
ATOM 2404 C CA  . SER A 1 324 ? 145.884 123.556 126.187 1.00 74.73  ? 324 SER A CA  1 
ATOM 2405 C C   . SER A 1 324 ? 144.540 123.552 126.906 1.00 76.64  ? 324 SER A C   1 
ATOM 2406 O O   . SER A 1 324 ? 143.874 122.520 126.991 1.00 77.92  ? 324 SER A O   1 
ATOM 2407 C CB  . SER A 1 324 ? 146.983 123.055 127.126 1.00 74.50  ? 324 SER A CB  1 
ATOM 2408 O OG  . SER A 1 324 ? 148.267 123.399 126.634 1.00 75.55  ? 324 SER A OG  1 
ATOM 2409 N N   . GLN A 1 337 ? 148.287 117.788 101.137 1.00 80.98  ? 337 GLN A N   1 
ATOM 2410 C CA  . GLN A 1 337 ? 148.578 118.971 100.336 1.00 82.34  ? 337 GLN A CA  1 
ATOM 2411 C C   . GLN A 1 337 ? 148.166 120.241 101.068 1.00 82.65  ? 337 GLN A C   1 
ATOM 2412 O O   . GLN A 1 337 ? 147.679 120.190 102.198 1.00 82.70  ? 337 GLN A O   1 
ATOM 2413 C CB  . GLN A 1 337 ? 147.875 118.884 98.981  1.00 81.12  ? 337 GLN A CB  1 
ATOM 2414 C CG  . GLN A 1 337 ? 146.415 118.480 99.065  1.00 82.67  ? 337 GLN A CG  1 
ATOM 2415 C CD  . GLN A 1 337 ? 145.823 118.157 97.709  1.00 87.05  ? 337 GLN A CD  1 
ATOM 2416 O OE1 . GLN A 1 337 ? 146.493 118.269 96.683  1.00 86.44  ? 337 GLN A OE1 1 
ATOM 2417 N NE2 . GLN A 1 337 ? 144.557 117.756 97.697  1.00 87.62  ? 337 GLN A NE2 1 
ATOM 2418 N N   . GLN A 1 338 ? 148.371 121.385 100.422 1.00 74.32  ? 338 GLN A N   1 
ATOM 2419 C CA  . GLN A 1 338 ? 148.075 122.679 101.015 1.00 70.25  ? 338 GLN A CA  1 
ATOM 2420 C C   . GLN A 1 338 ? 147.324 123.548 100.019 1.00 71.34  ? 338 GLN A C   1 
ATOM 2421 O O   . GLN A 1 338 ? 147.679 123.607 98.838  1.00 71.57  ? 338 GLN A O   1 
ATOM 2422 C CB  . GLN A 1 338 ? 149.359 123.393 101.468 1.00 73.85  ? 338 GLN A CB  1 
ATOM 2423 C CG  . GLN A 1 338 ? 149.852 122.988 102.853 1.00 73.17  ? 338 GLN A CG  1 
ATOM 2424 C CD  . GLN A 1 338 ? 151.055 123.797 103.312 1.00 72.07  ? 338 GLN A CD  1 
ATOM 2425 O OE1 . GLN A 1 338 ? 151.204 124.968 102.964 1.00 70.71  ? 338 GLN A OE1 1 
ATOM 2426 N NE2 . GLN A 1 338 ? 151.925 123.168 104.091 1.00 70.81  ? 338 GLN A NE2 1 
ATOM 2427 N N   . ALA A 1 339 ? 146.281 124.210 100.510 1.00 66.10  ? 339 ALA A N   1 
ATOM 2428 C CA  . ALA A 1 339 ? 145.567 125.203 99.729  1.00 67.33  ? 339 ALA A CA  1 
ATOM 2429 C C   . ALA A 1 339 ? 146.463 126.426 99.508  1.00 65.72  ? 339 ALA A C   1 
ATOM 2430 O O   . ALA A 1 339 ? 147.296 126.750 100.359 1.00 64.30  ? 339 ALA A O   1 
ATOM 2431 C CB  . ALA A 1 339 ? 144.277 125.586 100.452 1.00 65.26  ? 339 ALA A CB  1 
ATOM 2432 N N   . PRO A 1 340 ? 146.323 127.130 98.360  1.00 71.90  ? 340 PRO A N   1 
ATOM 2433 C CA  . PRO A 1 340 ? 147.322 128.141 98.023  1.00 63.80  ? 340 PRO A CA  1 
ATOM 2434 C C   . PRO A 1 340 ? 147.181 129.445 98.797  1.00 67.38  ? 340 PRO A C   1 
ATOM 2435 O O   . PRO A 1 340 ? 146.510 129.493 99.835  1.00 65.21  ? 340 PRO A O   1 
ATOM 2436 C CB  . PRO A 1 340 ? 147.086 128.313 96.513  1.00 64.21  ? 340 PRO A CB  1 
ATOM 2437 C CG  . PRO A 1 340 ? 145.559 127.886 96.333  1.00 66.20  ? 340 PRO A CG  1 
ATOM 2438 C CD  . PRO A 1 340 ? 145.082 127.621 97.731  1.00 63.53  ? 340 PRO A CD  1 
ATOM 2439 N N   . ARG A 1 341 ? 147.892 130.482 98.353  1.00 68.94  ? 341 ARG A N   1 
ATOM 2440 C CA  . ARG A 1 341 ? 147.833 131.774 99.026  1.00 62.53  ? 341 ARG A CA  1 
ATOM 2441 C C   . ARG A 1 341 ? 146.421 132.340 98.953  1.00 62.00  ? 341 ARG A C   1 
ATOM 2442 O O   . ARG A 1 341 ? 145.888 132.576 97.865  1.00 63.26  ? 341 ARG A O   1 
ATOM 2443 C CB  . ARG A 1 341 ? 148.830 132.743 98.392  1.00 64.05  ? 341 ARG A CB  1 
ATOM 2444 C CG  . ARG A 1 341 ? 149.208 133.908 99.282  1.00 66.01  ? 341 ARG A CG  1 
ATOM 2445 C CD  . ARG A 1 341 ? 149.996 133.438 100.492 1.00 67.72  ? 341 ARG A CD  1 
ATOM 2446 N NE  . ARG A 1 341 ? 149.160 133.380 101.685 1.00 62.39  ? 341 ARG A NE  1 
ATOM 2447 C CZ  . ARG A 1 341 ? 149.604 133.113 102.905 1.00 64.10  ? 341 ARG A CZ  1 
ATOM 2448 N NH1 . ARG A 1 341 ? 150.884 132.876 103.138 1.00 58.76  ? 341 ARG A NH1 1 
ATOM 2449 N NH2 . ARG A 1 341 ? 148.740 133.075 103.914 1.00 61.52  ? 341 ARG A NH2 1 
ATOM 2450 N N   . SER A 1 342 ? 145.813 132.541 100.119 1.00 48.46  ? 342 SER A N   1 
ATOM 2451 C CA  . SER A 1 342 ? 144.428 132.968 100.194 1.00 55.81  ? 342 SER A CA  1 
ATOM 2452 C C   . SER A 1 342 ? 144.295 134.427 99.765  1.00 60.30  ? 342 SER A C   1 
ATOM 2453 O O   . SER A 1 342 ? 145.279 135.155 99.610  1.00 60.42  ? 342 SER A O   1 
ATOM 2454 C CB  . SER A 1 342 ? 143.884 132.769 101.606 1.00 53.36  ? 342 SER A CB  1 
ATOM 2455 O OG  . SER A 1 342 ? 142.491 133.011 101.652 1.00 55.10  ? 342 SER A OG  1 
ATOM 2456 N N   . ARG A 1 343 ? 143.052 134.854 99.564  1.00 52.05  ? 343 ARG A N   1 
ATOM 2457 C CA  . ARG A 1 343 ? 142.770 136.170 99.012  1.00 41.47  ? 343 ARG A CA  1 
ATOM 2458 C C   . ARG A 1 343 ? 142.201 137.137 100.038 1.00 47.87  ? 343 ARG A C   1 
ATOM 2459 O O   . ARG A 1 343 ? 142.606 138.303 100.071 1.00 60.64  ? 343 ARG A O   1 
ATOM 2460 C CB  . ARG A 1 343 ? 141.815 136.029 97.815  1.00 47.75  ? 343 ARG A CB  1 
ATOM 2461 C CG  . ARG A 1 343 ? 141.401 137.333 97.139  1.00 53.02  ? 343 ARG A CG  1 
ATOM 2462 C CD  . ARG A 1 343 ? 142.577 138.235 96.774  1.00 58.13  ? 343 ARG A CD  1 
ATOM 2463 N NE  . ARG A 1 343 ? 143.688 137.535 96.140  1.00 57.73  ? 343 ARG A NE  1 
ATOM 2464 C CZ  . ARG A 1 343 ? 144.004 137.640 94.857  1.00 57.51  ? 343 ARG A CZ  1 
ATOM 2465 N NH1 . ARG A 1 343 ? 143.304 138.403 94.033  1.00 53.77  ? 343 ARG A NH1 1 
ATOM 2466 N NH2 . ARG A 1 343 ? 145.050 136.966 94.389  1.00 53.80  ? 343 ARG A NH2 1 
ATOM 2467 N N   . SER A 1 344 ? 141.281 136.691 100.889 1.00 36.05  ? 344 SER A N   1 
ATOM 2468 C CA  . SER A 1 344 ? 140.666 137.598 101.855 1.00 36.99  ? 344 SER A CA  1 
ATOM 2469 C C   . SER A 1 344 ? 140.113 136.800 103.021 1.00 27.71  ? 344 SER A C   1 
ATOM 2470 O O   . SER A 1 344 ? 139.226 135.965 102.829 1.00 33.07  ? 344 SER A O   1 
ATOM 2471 C CB  . SER A 1 344 ? 139.557 138.405 101.203 1.00 39.42  ? 344 SER A CB  1 
ATOM 2472 O OG  . SER A 1 344 ? 138.629 138.852 102.175 1.00 38.31  ? 344 SER A OG  1 
ATOM 2473 N N   . LEU A 1 345 ? 140.618 137.062 104.219 1.00 18.64  ? 345 LEU A N   1 
ATOM 2474 C CA  . LEU A 1 345 ? 140.050 136.449 105.405 1.00 25.02  ? 345 LEU A CA  1 
ATOM 2475 C C   . LEU A 1 345 ? 138.739 137.131 105.771 1.00 7.10   ? 345 LEU A C   1 
ATOM 2476 O O   . LEU A 1 345 ? 138.465 138.263 105.369 1.00 29.43  ? 345 LEU A O   1 
ATOM 2477 C CB  . LEU A 1 345 ? 141.029 136.517 106.578 1.00 33.68  ? 345 LEU A CB  1 
ATOM 2478 C CG  . LEU A 1 345 ? 141.117 137.814 107.381 1.00 27.51  ? 345 LEU A CG  1 
ATOM 2479 C CD1 . LEU A 1 345 ? 142.007 137.622 108.587 1.00 25.65  ? 345 LEU A CD1 1 
ATOM 2480 C CD2 . LEU A 1 345 ? 141.657 138.931 106.515 1.00 28.92  ? 345 LEU A CD2 1 
ATOM 2481 N N   . ILE A 1 346 ? 137.914 136.415 106.526 1.00 9.20   ? 346 ILE A N   1 
ATOM 2482 C CA  . ILE A 1 346 ? 136.643 136.931 107.019 1.00 26.44  ? 346 ILE A CA  1 
ATOM 2483 C C   . ILE A 1 346 ? 136.714 136.946 108.538 1.00 26.61  ? 346 ILE A C   1 
ATOM 2484 O O   . ILE A 1 346 ? 136.919 135.902 109.168 1.00 44.83  ? 346 ILE A O   1 
ATOM 2485 C CB  . ILE A 1 346 ? 135.451 136.097 106.518 1.00 35.03  ? 346 ILE A CB  1 
ATOM 2486 C CG1 . ILE A 1 346 ? 135.091 136.495 105.084 1.00 28.61  ? 346 ILE A CG1 1 
ATOM 2487 C CG2 . ILE A 1 346 ? 134.235 136.272 107.414 1.00 33.23  ? 346 ILE A CG2 1 
ATOM 2488 C CD1 . ILE A 1 346 ? 133.902 135.753 104.516 1.00 32.04  ? 346 ILE A CD1 1 
ATOM 2489 N N   . VAL A 1 347 ? 136.579 138.126 109.116 1.00 40.14  ? 347 VAL A N   1 
ATOM 2490 C CA  . VAL A 1 347 ? 136.542 138.280 110.562 1.00 39.37  ? 347 VAL A CA  1 
ATOM 2491 C C   . VAL A 1 347 ? 135.129 137.947 111.022 1.00 33.35  ? 347 VAL A C   1 
ATOM 2492 O O   . VAL A 1 347 ? 134.182 137.993 110.233 1.00 48.83  ? 347 VAL A O   1 
ATOM 2493 C CB  . VAL A 1 347 ? 136.974 139.716 110.935 1.00 43.98  ? 347 VAL A CB  1 
ATOM 2494 C CG1 . VAL A 1 347 ? 137.123 139.916 112.434 1.00 42.96  ? 347 VAL A CG1 1 
ATOM 2495 C CG2 . VAL A 1 347 ? 138.265 140.084 110.227 1.00 44.65  ? 347 VAL A CG2 1 
ATOM 2496 N N   . HIS A 1 348 ? 134.970 137.565 112.286 1.00 1.00   ? 348 HIS A N   1 
ATOM 2497 C CA  . HIS A 1 348 ? 133.641 137.280 112.813 1.00 16.02  ? 348 HIS A CA  1 
ATOM 2498 C C   . HIS A 1 348 ? 133.612 137.589 114.299 1.00 19.67  ? 348 HIS A C   1 
ATOM 2499 O O   . HIS A 1 348 ? 134.520 137.194 115.034 1.00 28.57  ? 348 HIS A O   1 
ATOM 2500 C CB  . HIS A 1 348 ? 133.255 135.825 112.557 1.00 25.52  ? 348 HIS A CB  1 
ATOM 2501 C CG  . HIS A 1 348 ? 131.885 135.466 113.040 1.00 26.15  ? 348 HIS A CG  1 
ATOM 2502 N ND1 . HIS A 1 348 ? 131.616 135.141 114.352 1.00 23.49  ? 348 HIS A ND1 1 
ATOM 2503 C CD2 . HIS A 1 348 ? 130.706 135.380 112.383 1.00 24.21  ? 348 HIS A CD2 1 
ATOM 2504 C CE1 . HIS A 1 348 ? 130.331 134.869 114.482 1.00 20.88  ? 348 HIS A CE1 1 
ATOM 2505 N NE2 . HIS A 1 348 ? 129.756 135.005 113.301 1.00 22.93  ? 348 HIS A NE2 1 
ATOM 2506 N N   . PHE A 1 349 ? 132.574 138.297 114.731 1.00 27.76  ? 349 PHE A N   1 
ATOM 2507 C CA  . PHE A 1 349 ? 132.265 138.496 116.139 1.00 21.02  ? 349 PHE A CA  1 
ATOM 2508 C C   . PHE A 1 349 ? 130.920 137.845 116.421 1.00 43.06  ? 349 PHE A C   1 
ATOM 2509 O O   . PHE A 1 349 ? 129.956 138.069 115.683 1.00 45.03  ? 349 PHE A O   1 
ATOM 2510 C CB  . PHE A 1 349 ? 132.208 139.981 116.497 1.00 17.76  ? 349 PHE A CB  1 
ATOM 2511 C CG  . PHE A 1 349 ? 133.395 140.770 116.032 1.00 16.86  ? 349 PHE A CG  1 
ATOM 2512 C CD1 . PHE A 1 349 ? 134.612 140.663 116.676 1.00 22.84  ? 349 PHE A CD1 1 
ATOM 2513 C CD2 . PHE A 1 349 ? 133.290 141.629 114.953 1.00 32.39  ? 349 PHE A CD2 1 
ATOM 2514 C CE1 . PHE A 1 349 ? 135.701 141.391 116.245 1.00 21.61  ? 349 PHE A CE1 1 
ATOM 2515 C CE2 . PHE A 1 349 ? 134.377 142.362 114.527 1.00 32.78  ? 349 PHE A CE2 1 
ATOM 2516 C CZ  . PHE A 1 349 ? 135.582 142.241 115.172 1.00 20.92  ? 349 PHE A CZ  1 
ATOM 2517 N N   . HIS A 1 350 ? 130.852 137.044 117.479 1.00 36.33  ? 350 HIS A N   1 
ATOM 2518 C CA  . HIS A 1 350 ? 129.609 136.356 117.785 1.00 35.80  ? 350 HIS A CA  1 
ATOM 2519 C C   . HIS A 1 350 ? 128.592 137.326 118.386 1.00 29.96  ? 350 HIS A C   1 
ATOM 2520 O O   . HIS A 1 350 ? 128.894 138.482 118.693 1.00 33.10  ? 350 HIS A O   1 
ATOM 2521 C CB  . HIS A 1 350 ? 129.859 135.189 118.740 1.00 33.63  ? 350 HIS A CB  1 
ATOM 2522 C CG  . HIS A 1 350 ? 130.460 135.591 120.051 1.00 27.88  ? 350 HIS A CG  1 
ATOM 2523 N ND1 . HIS A 1 350 ? 131.774 135.337 120.374 1.00 26.98  ? 350 HIS A ND1 1 
ATOM 2524 C CD2 . HIS A 1 350 ? 129.924 136.216 121.126 1.00 29.71  ? 350 HIS A CD2 1 
ATOM 2525 C CE1 . HIS A 1 350 ? 132.023 135.794 121.588 1.00 31.57  ? 350 HIS A CE1 1 
ATOM 2526 N NE2 . HIS A 1 350 ? 130.917 136.332 122.066 1.00 29.64  ? 350 HIS A NE2 1 
ATOM 2527 N N   . GLY A 1 351 ? 127.369 136.835 118.558 1.00 29.20  ? 351 GLY A N   1 
ATOM 2528 C CA  . GLY A 1 351 ? 126.323 137.618 119.184 1.00 33.92  ? 351 GLY A CA  1 
ATOM 2529 C C   . GLY A 1 351 ? 126.115 137.244 120.635 1.00 40.47  ? 351 GLY A C   1 
ATOM 2530 O O   . GLY A 1 351 ? 127.033 137.363 121.450 1.00 41.67  ? 351 GLY A O   1 
ATOM 2531 N N   . GLY A 1 352 ? 124.915 136.785 120.969 1.00 45.56  ? 352 GLY A N   1 
ATOM 2532 C CA  . GLY A 1 352 ? 124.631 136.312 122.312 1.00 45.11  ? 352 GLY A CA  1 
ATOM 2533 C C   . GLY A 1 352 ? 124.607 137.362 123.402 1.00 43.95  ? 352 GLY A C   1 
ATOM 2534 O O   . GLY A 1 352 ? 125.100 137.108 124.508 1.00 36.20  ? 352 GLY A O   1 
ATOM 2535 N N   . GLY A 1 353 ? 124.057 138.540 123.112 1.00 55.82  ? 353 GLY A N   1 
ATOM 2536 C CA  . GLY A 1 353 ? 123.727 139.525 124.127 1.00 58.92  ? 353 GLY A CA  1 
ATOM 2537 C C   . GLY A 1 353 ? 124.884 140.121 124.895 1.00 51.10  ? 353 GLY A C   1 
ATOM 2538 O O   . GLY A 1 353 ? 124.657 140.676 125.975 1.00 64.81  ? 353 GLY A O   1 
ATOM 2539 N N   . PHE A 1 354 ? 126.117 139.995 124.395 1.00 33.62  ? 354 PHE A N   1 
ATOM 2540 C CA  . PHE A 1 354 ? 127.359 140.403 125.056 1.00 50.27  ? 354 PHE A CA  1 
ATOM 2541 C C   . PHE A 1 354 ? 127.554 139.759 126.422 1.00 50.57  ? 354 PHE A C   1 
ATOM 2542 O O   . PHE A 1 354 ? 128.412 140.205 127.191 1.00 49.90  ? 354 PHE A O   1 
ATOM 2543 C CB  . PHE A 1 354 ? 127.475 141.929 125.206 1.00 53.35  ? 354 PHE A CB  1 
ATOM 2544 C CG  . PHE A 1 354 ? 127.820 142.643 123.935 1.00 47.53  ? 354 PHE A CG  1 
ATOM 2545 C CD1 . PHE A 1 354 ? 126.850 142.913 122.992 1.00 46.93  ? 354 PHE A CD1 1 
ATOM 2546 C CD2 . PHE A 1 354 ? 129.123 143.033 123.679 1.00 54.45  ? 354 PHE A CD2 1 
ATOM 2547 C CE1 . PHE A 1 354 ? 127.166 143.567 121.825 1.00 45.49  ? 354 PHE A CE1 1 
ATOM 2548 C CE2 . PHE A 1 354 ? 129.446 143.684 122.509 1.00 54.39  ? 354 PHE A CE2 1 
ATOM 2549 C CZ  . PHE A 1 354 ? 128.466 143.952 121.581 1.00 50.59  ? 354 PHE A CZ  1 
ATOM 2550 N N   . VAL A 1 355 ? 126.782 138.728 126.750 1.00 41.41  ? 355 VAL A N   1 
ATOM 2551 C CA  . VAL A 1 355 ? 126.867 138.082 128.050 1.00 48.58  ? 355 VAL A CA  1 
ATOM 2552 C C   . VAL A 1 355 ? 127.058 136.577 127.948 1.00 49.60  ? 355 VAL A C   1 
ATOM 2553 O O   . VAL A 1 355 ? 127.479 135.955 128.936 1.00 50.01  ? 355 VAL A O   1 
ATOM 2554 C CB  . VAL A 1 355 ? 125.627 138.401 128.915 1.00 48.17  ? 355 VAL A CB  1 
ATOM 2555 C CG1 . VAL A 1 355 ? 125.535 139.893 129.214 1.00 48.17  ? 355 VAL A CG1 1 
ATOM 2556 C CG2 . VAL A 1 355 ? 124.362 137.926 128.222 1.00 48.16  ? 355 VAL A CG2 1 
ATOM 2557 N N   . ALA A 1 356 ? 126.787 135.966 126.800 1.00 44.41  ? 356 ALA A N   1 
ATOM 2558 C CA  . ALA A 1 356 ? 126.902 134.524 126.646 1.00 48.01  ? 356 ALA A CA  1 
ATOM 2559 C C   . ALA A 1 356 ? 127.106 134.214 125.169 1.00 46.74  ? 356 ALA A C   1 
ATOM 2560 O O   . ALA A 1 356 ? 127.362 135.114 124.361 1.00 42.99  ? 356 ALA A O   1 
ATOM 2561 C CB  . ALA A 1 356 ? 125.670 133.815 127.214 1.00 47.43  ? 356 ALA A CB  1 
ATOM 2562 N N   . GLN A 1 357 ? 126.985 132.928 124.825 1.00 49.85  ? 357 GLN A N   1 
ATOM 2563 C CA  . GLN A 1 357 ? 127.113 132.405 123.463 1.00 45.39  ? 357 GLN A CA  1 
ATOM 2564 C C   . GLN A 1 357 ? 128.485 132.746 122.870 1.00 45.43  ? 357 GLN A C   1 
ATOM 2565 O O   . GLN A 1 357 ? 128.624 133.556 121.954 1.00 46.73  ? 357 GLN A O   1 
ATOM 2566 C CB  . GLN A 1 357 ? 125.979 132.895 122.555 1.00 38.64  ? 357 GLN A CB  1 
ATOM 2567 C CG  . GLN A 1 357 ? 125.846 132.084 121.279 1.00 41.47  ? 357 GLN A CG  1 
ATOM 2568 C CD  . GLN A 1 357 ? 124.486 132.213 120.634 1.00 50.36  ? 357 GLN A CD  1 
ATOM 2569 O OE1 . GLN A 1 357 ? 123.893 131.223 120.209 1.00 51.01  ? 357 GLN A OE1 1 
ATOM 2570 N NE2 . GLN A 1 357 ? 123.990 133.440 120.540 1.00 46.15  ? 357 GLN A NE2 1 
ATOM 2571 N N   . THR A 1 358 ? 129.502 132.110 123.441 1.00 45.39  ? 358 THR A N   1 
ATOM 2572 C CA  . THR A 1 358 ? 130.877 132.300 122.994 1.00 45.90  ? 358 THR A CA  1 
ATOM 2573 C C   . THR A 1 358 ? 131.077 131.660 121.616 1.00 42.96  ? 358 THR A C   1 
ATOM 2574 O O   . THR A 1 358 ? 130.151 131.130 120.996 1.00 49.13  ? 358 THR A O   1 
ATOM 2575 C CB  . THR A 1 358 ? 131.853 131.730 124.018 1.00 45.56  ? 358 THR A CB  1 
ATOM 2576 O OG1 . THR A 1 358 ? 131.987 130.318 123.818 1.00 45.96  ? 358 THR A OG1 1 
ATOM 2577 C CG2 . THR A 1 358 ? 131.358 131.992 125.432 1.00 53.28  ? 358 THR A CG2 1 
ATOM 2578 N N   . SER A 1 359 ? 132.317 131.689 121.129 1.00 39.60  ? 359 SER A N   1 
ATOM 2579 C CA  . SER A 1 359 ? 132.602 131.273 119.761 1.00 41.67  ? 359 SER A CA  1 
ATOM 2580 C C   . SER A 1 359 ? 132.473 129.774 119.545 1.00 41.10  ? 359 SER A C   1 
ATOM 2581 O O   . SER A 1 359 ? 132.527 129.335 118.393 1.00 40.12  ? 359 SER A O   1 
ATOM 2582 C CB  . SER A 1 359 ? 134.005 131.718 119.355 1.00 39.50  ? 359 SER A CB  1 
ATOM 2583 O OG  . SER A 1 359 ? 134.209 131.540 117.966 1.00 33.54  ? 359 SER A OG  1 
ATOM 2584 N N   . ARG A 1 360 ? 132.300 128.983 120.605 1.00 55.52  ? 360 ARG A N   1 
ATOM 2585 C CA  . ARG A 1 360 ? 132.143 127.539 120.491 1.00 61.62  ? 360 ARG A CA  1 
ATOM 2586 C C   . ARG A 1 360 ? 130.723 127.111 120.097 1.00 65.87  ? 360 ARG A C   1 
ATOM 2587 O O   . ARG A 1 360 ? 130.399 125.924 120.217 1.00 64.98  ? 360 ARG A O   1 
ATOM 2588 C CB  . ARG A 1 360 ? 132.537 126.857 121.804 1.00 58.32  ? 360 ARG A CB  1 
ATOM 2589 C CG  . ARG A 1 360 ? 134.022 126.679 122.040 1.00 56.25  ? 360 ARG A CG  1 
ATOM 2590 C CD  . ARG A 1 360 ? 134.225 125.714 123.197 1.00 59.67  ? 360 ARG A CD  1 
ATOM 2591 N NE  . ARG A 1 360 ? 133.253 124.627 123.155 1.00 59.11  ? 360 ARG A NE  1 
ATOM 2592 C CZ  . ARG A 1 360 ? 132.815 123.968 124.219 1.00 65.53  ? 360 ARG A CZ  1 
ATOM 2593 N NH1 . ARG A 1 360 ? 133.216 124.281 125.440 1.00 66.21  ? 360 ARG A NH1 1 
ATOM 2594 N NH2 . ARG A 1 360 ? 131.944 122.977 124.055 1.00 63.82  ? 360 ARG A NH2 1 
ATOM 2595 N N   . SER A 1 361 ? 129.874 128.033 119.635 1.00 57.57  ? 361 SER A N   1 
ATOM 2596 C CA  . SER A 1 361 ? 128.460 127.739 119.427 1.00 47.14  ? 361 SER A CA  1 
ATOM 2597 C C   . SER A 1 361 ? 127.985 128.054 118.016 1.00 49.86  ? 361 SER A C   1 
ATOM 2598 O O   . SER A 1 361 ? 126.950 127.541 117.581 1.00 48.28  ? 361 SER A O   1 
ATOM 2599 C CB  . SER A 1 361 ? 127.604 128.519 120.425 1.00 38.42  ? 361 SER A CB  1 
ATOM 2600 O OG  . SER A 1 361 ? 126.227 128.368 120.135 1.00 49.63  ? 361 SER A OG  1 
ATOM 2601 N N   . HIS A 1 362 ? 128.709 128.901 117.298 1.00 48.38  ? 362 HIS A N   1 
ATOM 2602 C CA  . HIS A 1 362 ? 128.225 129.386 116.016 1.00 46.73  ? 362 HIS A CA  1 
ATOM 2603 C C   . HIS A 1 362 ? 128.767 128.598 114.830 1.00 43.97  ? 362 HIS A C   1 
ATOM 2604 O O   . HIS A 1 362 ? 128.488 128.975 113.688 1.00 42.71  ? 362 HIS A O   1 
ATOM 2605 C CB  . HIS A 1 362 ? 128.557 130.875 115.867 1.00 46.18  ? 362 HIS A CB  1 
ATOM 2606 C CG  . HIS A 1 362 ? 127.716 131.762 116.733 1.00 46.33  ? 362 HIS A CG  1 
ATOM 2607 N ND1 . HIS A 1 362 ? 126.464 132.200 116.360 1.00 49.83  ? 362 HIS A ND1 1 
ATOM 2608 C CD2 . HIS A 1 362 ? 127.947 132.286 117.960 1.00 41.63  ? 362 HIS A CD2 1 
ATOM 2609 C CE1 . HIS A 1 362 ? 125.955 132.945 117.324 1.00 44.12  ? 362 HIS A CE1 1 
ATOM 2610 N NE2 . HIS A 1 362 ? 126.840 133.024 118.300 1.00 46.83  ? 362 HIS A NE2 1 
ATOM 2611 N N   . GLU A 1 363 ? 129.517 127.518 115.071 1.00 41.40  ? 363 GLU A N   1 
ATOM 2612 C CA  . GLU A 1 363 ? 130.022 126.693 113.970 1.00 43.41  ? 363 GLU A CA  1 
ATOM 2613 C C   . GLU A 1 363 ? 128.966 126.103 113.037 1.00 42.90  ? 363 GLU A C   1 
ATOM 2614 O O   . GLU A 1 363 ? 129.188 126.182 111.817 1.00 40.83  ? 363 GLU A O   1 
ATOM 2615 C CB  . GLU A 1 363 ? 130.918 125.541 114.460 1.00 40.97  ? 363 GLU A CB  1 
ATOM 2616 C CG  . GLU A 1 363 ? 132.037 125.815 115.445 1.00 42.42  ? 363 GLU A CG  1 
ATOM 2617 C CD  . GLU A 1 363 ? 131.597 126.270 116.807 1.00 43.10  ? 363 GLU A CD  1 
ATOM 2618 O OE1 . GLU A 1 363 ? 130.382 126.194 117.039 1.00 37.20  ? 363 GLU A OE1 1 
ATOM 2619 O OE2 . GLU A 1 363 ? 132.442 126.702 117.621 1.00 42.48  ? 363 GLU A OE2 1 
ATOM 2620 N N   . PRO A 1 364 ? 127.839 125.517 113.492 1.00 44.76  ? 364 PRO A N   1 
ATOM 2621 C CA  . PRO A 1 364 ? 126.947 124.807 112.545 1.00 51.90  ? 364 PRO A CA  1 
ATOM 2622 C C   . PRO A 1 364 ? 126.438 125.628 111.361 1.00 43.99  ? 364 PRO A C   1 
ATOM 2623 O O   . PRO A 1 364 ? 125.933 125.040 110.397 1.00 50.74  ? 364 PRO A O   1 
ATOM 2624 C CB  . PRO A 1 364 ? 125.783 124.345 113.438 1.00 53.76  ? 364 PRO A CB  1 
ATOM 2625 C CG  . PRO A 1 364 ? 125.939 125.087 114.716 1.00 52.20  ? 364 PRO A CG  1 
ATOM 2626 C CD  . PRO A 1 364 ? 127.397 125.243 114.873 1.00 46.81  ? 364 PRO A CD  1 
ATOM 2627 N N   . TYR A 1 365 ? 126.571 126.952 111.389 1.00 26.14  ? 365 TYR A N   1 
ATOM 2628 C CA  . TYR A 1 365 ? 126.483 127.747 110.175 1.00 37.52  ? 365 TYR A CA  1 
ATOM 2629 C C   . TYR A 1 365 ? 127.816 128.376 109.775 1.00 52.46  ? 365 TYR A C   1 
ATOM 2630 O O   . TYR A 1 365 ? 127.966 128.776 108.616 1.00 60.12  ? 365 TYR A O   1 
ATOM 2631 C CB  . TYR A 1 365 ? 125.401 128.827 110.321 1.00 39.12  ? 365 TYR A CB  1 
ATOM 2632 C CG  . TYR A 1 365 ? 125.707 129.932 111.304 1.00 37.93  ? 365 TYR A CG  1 
ATOM 2633 C CD1 . TYR A 1 365 ? 125.532 129.744 112.668 1.00 39.75  ? 365 TYR A CD1 1 
ATOM 2634 C CD2 . TYR A 1 365 ? 126.132 131.176 110.863 1.00 36.38  ? 365 TYR A CD2 1 
ATOM 2635 C CE1 . TYR A 1 365 ? 125.797 130.753 113.562 1.00 42.20  ? 365 TYR A CE1 1 
ATOM 2636 C CE2 . TYR A 1 365 ? 126.398 132.190 111.753 1.00 35.31  ? 365 TYR A CE2 1 
ATOM 2637 C CZ  . TYR A 1 365 ? 126.230 131.975 113.100 1.00 34.66  ? 365 TYR A CZ  1 
ATOM 2638 O OH  . TYR A 1 365 ? 126.496 132.987 113.989 1.00 24.59  ? 365 TYR A OH  1 
ATOM 2639 N N   . LEU A 1 366 ? 128.786 128.464 110.694 1.00 47.24  ? 366 LEU A N   1 
ATOM 2640 C CA  . LEU A 1 366 ? 130.126 128.914 110.320 1.00 36.88  ? 366 LEU A CA  1 
ATOM 2641 C C   . LEU A 1 366 ? 130.834 127.892 109.438 1.00 39.77  ? 366 LEU A C   1 
ATOM 2642 O O   . LEU A 1 366 ? 131.559 128.274 108.514 1.00 48.95  ? 366 LEU A O   1 
ATOM 2643 C CB  . LEU A 1 366 ? 130.963 129.197 111.571 1.00 28.59  ? 366 LEU A CB  1 
ATOM 2644 C CG  . LEU A 1 366 ? 130.930 130.562 112.259 1.00 29.99  ? 366 LEU A CG  1 
ATOM 2645 C CD1 . LEU A 1 366 ? 131.504 130.465 113.651 1.00 27.95  ? 366 LEU A CD1 1 
ATOM 2646 C CD2 . LEU A 1 366 ? 131.745 131.531 111.478 1.00 33.07  ? 366 LEU A CD2 1 
ATOM 2647 N N   . LYS A 1 367 ? 130.658 126.595 109.719 1.00 51.55  ? 367 LYS A N   1 
ATOM 2648 C CA  . LYS A 1 367 ? 131.224 125.567 108.851 1.00 45.69  ? 367 LYS A CA  1 
ATOM 2649 C C   . LYS A 1 367 ? 130.502 125.559 107.513 1.00 48.40  ? 367 LYS A C   1 
ATOM 2650 O O   . LYS A 1 367 ? 131.116 125.331 106.464 1.00 42.94  ? 367 LYS A O   1 
ATOM 2651 C CB  . LYS A 1 367 ? 131.115 124.201 109.524 1.00 40.31  ? 367 LYS A CB  1 
ATOM 2652 C CG  . LYS A 1 367 ? 131.307 124.275 111.023 1.00 37.21  ? 367 LYS A CG  1 
ATOM 2653 C CD  . LYS A 1 367 ? 132.703 124.414 111.555 1.00 41.15  ? 367 LYS A CD  1 
ATOM 2654 C CE  . LYS A 1 367 ? 133.354 123.030 111.514 1.00 50.39  ? 367 LYS A CE  1 
ATOM 2655 N NZ  . LYS A 1 367 ? 134.810 123.007 111.619 1.00 45.88  ? 367 LYS A NZ  1 
ATOM 2656 N N   . SER A 1 368 ? 129.193 125.827 107.534 1.00 46.44  ? 368 SER A N   1 
ATOM 2657 C CA  . SER A 1 368 ? 128.433 125.948 106.298 1.00 45.29  ? 368 SER A CA  1 
ATOM 2658 C C   . SER A 1 368 ? 128.731 127.256 105.580 1.00 41.92  ? 368 SER A C   1 
ATOM 2659 O O   . SER A 1 368 ? 128.415 127.392 104.394 1.00 46.14  ? 368 SER A O   1 
ATOM 2660 C CB  . SER A 1 368 ? 126.937 125.833 106.586 1.00 48.08  ? 368 SER A CB  1 
ATOM 2661 O OG  . SER A 1 368 ? 126.238 125.381 105.440 1.00 53.71  ? 368 SER A OG  1 
ATOM 2662 N N   . TRP A 1 369 ? 129.315 128.233 106.278 1.00 39.45  ? 369 TRP A N   1 
ATOM 2663 C CA  . TRP A 1 369 ? 129.755 129.448 105.601 1.00 42.00  ? 369 TRP A CA  1 
ATOM 2664 C C   . TRP A 1 369 ? 130.984 129.182 104.742 1.00 51.29  ? 369 TRP A C   1 
ATOM 2665 O O   . TRP A 1 369 ? 131.077 129.667 103.609 1.00 48.66  ? 369 TRP A O   1 
ATOM 2666 C CB  . TRP A 1 369 ? 130.049 130.552 106.615 1.00 35.10  ? 369 TRP A CB  1 
ATOM 2667 C CG  . TRP A 1 369 ? 128.873 131.413 106.943 1.00 40.89  ? 369 TRP A CG  1 
ATOM 2668 C CD1 . TRP A 1 369 ? 127.681 131.463 106.284 1.00 43.79  ? 369 TRP A CD1 1 
ATOM 2669 C CD2 . TRP A 1 369 ? 128.795 132.388 107.985 1.00 43.31  ? 369 TRP A CD2 1 
ATOM 2670 N NE1 . TRP A 1 369 ? 126.854 132.389 106.873 1.00 43.96  ? 369 TRP A NE1 1 
ATOM 2671 C CE2 . TRP A 1 369 ? 127.518 132.974 107.917 1.00 43.56  ? 369 TRP A CE2 1 
ATOM 2672 C CE3 . TRP A 1 369 ? 129.678 132.815 108.975 0.62 43.49  ? 369 TRP A CE3 1 
ATOM 2673 C CZ2 . TRP A 1 369 ? 127.104 133.962 108.804 1.00 49.30  ? 369 TRP A CZ2 1 
ATOM 2674 C CZ3 . TRP A 1 369 ? 129.266 133.793 109.852 1.00 42.56  ? 369 TRP A CZ3 1 
ATOM 2675 C CH2 . TRP A 1 369 ? 127.993 134.360 109.761 1.00 42.81  ? 369 TRP A CH2 1 
ATOM 2676 N N   . ALA A 1 370 ? 131.933 128.398 105.259 1.00 52.39  ? 370 ALA A N   1 
ATOM 2677 C CA  . ALA A 1 370 ? 133.208 128.180 104.586 1.00 44.12  ? 370 ALA A CA  1 
ATOM 2678 C C   . ALA A 1 370 ? 133.100 127.285 103.357 1.00 48.50  ? 370 ALA A C   1 
ATOM 2679 O O   . ALA A 1 370 ? 134.087 127.160 102.624 1.00 58.80  ? 370 ALA A O   1 
ATOM 2680 C CB  . ALA A 1 370 ? 134.218 127.585 105.567 1.00 42.46  ? 370 ALA A CB  1 
ATOM 2681 N N   . GLN A 1 371 ? 131.946 126.655 103.123 1.00 56.84  ? 371 GLN A N   1 
ATOM 2682 C CA  . GLN A 1 371 ? 131.796 125.770 101.971 1.00 57.62  ? 371 GLN A CA  1 
ATOM 2683 C C   . GLN A 1 371 ? 131.860 126.537 100.654 1.00 57.51  ? 371 GLN A C   1 
ATOM 2684 O O   . GLN A 1 371 ? 132.492 126.078 99.695  1.00 54.02  ? 371 GLN A O   1 
ATOM 2685 C CB  . GLN A 1 371 ? 130.485 124.991 102.080 1.00 53.30  ? 371 GLN A CB  1 
ATOM 2686 C CG  . GLN A 1 371 ? 130.342 123.839 101.096 1.00 50.61  ? 371 GLN A CG  1 
ATOM 2687 C CD  . GLN A 1 371 ? 131.520 122.888 101.123 1.00 54.71  ? 371 GLN A CD  1 
ATOM 2688 O OE1 . GLN A 1 371 ? 132.378 122.920 100.242 1.00 58.60  ? 371 GLN A OE1 1 
ATOM 2689 N NE2 . GLN A 1 371 ? 131.567 122.032 102.138 1.00 51.50  ? 371 GLN A NE2 1 
ATOM 2690 N N   . GLU A 1 372 ? 131.218 127.703 100.582 1.00 52.17  ? 372 GLU A N   1 
ATOM 2691 C CA  . GLU A 1 372 ? 131.188 128.474 99.344  1.00 52.98  ? 372 GLU A CA  1 
ATOM 2692 C C   . GLU A 1 372 ? 132.055 129.723 99.384  1.00 53.74  ? 372 GLU A C   1 
ATOM 2693 O O   . GLU A 1 372 ? 132.507 130.178 98.328  1.00 57.36  ? 372 GLU A O   1 
ATOM 2694 C CB  . GLU A 1 372 ? 129.752 128.886 98.991  1.00 50.63  ? 372 GLU A CB  1 
ATOM 2695 C CG  . GLU A 1 372 ? 128.986 129.604 100.097 1.00 45.73  ? 372 GLU A CG  1 
ATOM 2696 C CD  . GLU A 1 372 ? 128.268 128.658 101.035 1.00 53.41  ? 372 GLU A CD  1 
ATOM 2697 O OE1 . GLU A 1 372 ? 128.947 127.832 101.672 1.00 56.89  ? 372 GLU A OE1 1 
ATOM 2698 O OE2 . GLU A 1 372 ? 127.026 128.740 101.135 1.00 55.68  ? 372 GLU A OE2 1 
ATOM 2699 N N   . LEU A 1 373 ? 132.288 130.293 100.569 1.00 46.41  ? 373 LEU A N   1 
ATOM 2700 C CA  . LEU A 1 373 ? 133.075 131.519 100.653 1.00 49.03  ? 373 LEU A CA  1 
ATOM 2701 C C   . LEU A 1 373 ? 134.545 131.263 100.348 1.00 43.54  ? 373 LEU A C   1 
ATOM 2702 O O   . LEU A 1 373 ? 135.181 132.047 99.634  1.00 38.04  ? 373 LEU A O   1 
ATOM 2703 C CB  . LEU A 1 373 ? 132.917 132.153 102.035 1.00 48.95  ? 373 LEU A CB  1 
ATOM 2704 C CG  . LEU A 1 373 ? 131.527 132.691 102.368 1.00 37.64  ? 373 LEU A CG  1 
ATOM 2705 C CD1 . LEU A 1 373 ? 131.393 132.947 103.859 1.00 27.80  ? 373 LEU A CD1 1 
ATOM 2706 C CD2 . LEU A 1 373 ? 131.250 133.947 101.570 1.00 42.57  ? 373 LEU A CD2 1 
ATOM 2707 N N   . GLY A 1 374 ? 135.094 130.166 100.861 1.00 42.64  ? 374 GLY A N   1 
ATOM 2708 C CA  . GLY A 1 374 ? 136.509 129.884 100.678 1.00 38.43  ? 374 GLY A CA  1 
ATOM 2709 C C   . GLY A 1 374 ? 137.417 130.867 101.383 1.00 33.63  ? 374 GLY A C   1 
ATOM 2710 O O   . GLY A 1 374 ? 138.423 131.304 100.809 1.00 34.40  ? 374 GLY A O   1 
ATOM 2711 N N   . ALA A 1 375 ? 137.083 131.231 102.615 1.00 31.25  ? 375 ALA A N   1 
ATOM 2712 C CA  . ALA A 1 375 ? 137.859 132.192 103.376 1.00 25.63  ? 375 ALA A CA  1 
ATOM 2713 C C   . ALA A 1 375 ? 138.133 131.655 104.770 1.00 28.82  ? 375 ALA A C   1 
ATOM 2714 O O   . ALA A 1 375 ? 137.275 130.995 105.363 1.00 36.31  ? 375 ALA A O   1 
ATOM 2715 C CB  . ALA A 1 375 ? 137.120 133.532 103.478 1.00 33.39  ? 375 ALA A CB  1 
ATOM 2716 N N   . PRO A 1 376 ? 139.322 131.914 105.316 1.00 14.63  ? 376 PRO A N   1 
ATOM 2717 C CA  . PRO A 1 376 ? 139.606 131.484 106.692 1.00 15.94  ? 376 PRO A CA  1 
ATOM 2718 C C   . PRO A 1 376 ? 138.876 132.333 107.718 1.00 13.52  ? 376 PRO A C   1 
ATOM 2719 O O   . PRO A 1 376 ? 139.266 133.471 107.990 1.00 21.84  ? 376 PRO A O   1 
ATOM 2720 C CB  . PRO A 1 376 ? 141.127 131.643 106.804 1.00 14.46  ? 376 PRO A CB  1 
ATOM 2721 C CG  . PRO A 1 376 ? 141.487 132.633 105.757 1.00 12.66  ? 376 PRO A CG  1 
ATOM 2722 C CD  . PRO A 1 376 ? 140.514 132.448 104.639 1.00 8.49   ? 376 PRO A CD  1 
ATOM 2723 N N   . ILE A 1 377 ? 137.827 131.778 108.313 1.00 16.43  ? 377 ILE A N   1 
ATOM 2724 C CA  . ILE A 1 377 ? 136.924 132.542 109.164 1.00 15.19  ? 377 ILE A CA  1 
ATOM 2725 C C   . ILE A 1 377 ? 137.443 132.497 110.594 1.00 10.91  ? 377 ILE A C   1 
ATOM 2726 O O   . ILE A 1 377 ? 137.228 131.516 111.308 1.00 32.23  ? 377 ILE A O   1 
ATOM 2727 C CB  . ILE A 1 377 ? 135.494 132.003 109.088 1.00 19.68  ? 377 ILE A CB  1 
ATOM 2728 C CG1 . ILE A 1 377 ? 135.092 131.748 107.638 1.00 30.94  ? 377 ILE A CG1 1 
ATOM 2729 C CG2 . ILE A 1 377 ? 134.552 132.993 109.711 1.00 27.88  ? 377 ILE A CG2 1 
ATOM 2730 C CD1 . ILE A 1 377 ? 133.663 131.296 107.472 1.00 37.81  ? 377 ILE A CD1 1 
ATOM 2731 N N   . ILE A 1 378 ? 138.101 133.567 111.027 1.00 5.24   ? 378 ILE A N   1 
ATOM 2732 C CA  . ILE A 1 378 ? 138.588 133.665 112.397 1.00 3.67   ? 378 ILE A CA  1 
ATOM 2733 C C   . ILE A 1 378 ? 137.433 134.213 113.233 1.00 13.96  ? 378 ILE A C   1 
ATOM 2734 O O   . ILE A 1 378 ? 137.101 135.396 113.177 1.00 42.37  ? 378 ILE A O   1 
ATOM 2735 C CB  . ILE A 1 378 ? 139.858 134.517 112.489 1.00 3.42   ? 378 ILE A CB  1 
ATOM 2736 C CG1 . ILE A 1 378 ? 140.152 134.943 113.927 1.00 8.70   ? 378 ILE A CG1 1 
ATOM 2737 C CG2 . ILE A 1 378 ? 139.809 135.702 111.539 1.00 1.00   ? 378 ILE A CG2 1 
ATOM 2738 C CD1 . ILE A 1 378 ? 141.465 135.659 114.064 1.00 30.39  ? 378 ILE A CD1 1 
ATOM 2739 N N   . SER A 1 379 ? 136.784 133.330 113.981 1.00 15.55  ? 379 SER A N   1 
ATOM 2740 C CA  . SER A 1 379 ? 135.615 133.700 114.773 1.00 15.70  ? 379 SER A CA  1 
ATOM 2741 C C   . SER A 1 379 ? 136.086 134.117 116.157 1.00 16.64  ? 379 SER A C   1 
ATOM 2742 O O   . SER A 1 379 ? 136.255 133.280 117.045 1.00 35.93  ? 379 SER A O   1 
ATOM 2743 C CB  . SER A 1 379 ? 134.631 132.540 114.842 1.00 17.73  ? 379 SER A CB  1 
ATOM 2744 O OG  . SER A 1 379 ? 133.832 132.617 116.007 1.00 16.79  ? 379 SER A OG  1 
ATOM 2745 N N   . ILE A 1 380 ? 136.283 135.423 116.346 1.00 3.65   ? 380 ILE A N   1 
ATOM 2746 C CA  . ILE A 1 380 ? 136.883 135.937 117.571 1.00 7.89   ? 380 ILE A CA  1 
ATOM 2747 C C   . ILE A 1 380 ? 135.930 135.735 118.739 1.00 11.68  ? 380 ILE A C   1 
ATOM 2748 O O   . ILE A 1 380 ? 134.755 136.117 118.676 1.00 39.15  ? 380 ILE A O   1 
ATOM 2749 C CB  . ILE A 1 380 ? 137.240 137.422 117.410 1.00 15.29  ? 380 ILE A CB  1 
ATOM 2750 C CG1 . ILE A 1 380 ? 138.425 137.594 116.466 1.00 23.32  ? 380 ILE A CG1 1 
ATOM 2751 C CG2 . ILE A 1 380 ? 137.559 138.051 118.757 1.00 17.42  ? 380 ILE A CG2 1 
ATOM 2752 C CD1 . ILE A 1 380 ? 138.427 138.911 115.745 1.00 19.80  ? 380 ILE A CD1 1 
ATOM 2753 N N   . ASP A 1 381 ? 136.427 135.121 119.808 1.00 21.44  ? 381 ASP A N   1 
ATOM 2754 C CA  . ASP A 1 381 ? 135.679 135.043 121.059 1.00 27.94  ? 381 ASP A CA  1 
ATOM 2755 C C   . ASP A 1 381 ? 136.140 136.205 121.925 1.00 29.75  ? 381 ASP A C   1 
ATOM 2756 O O   . ASP A 1 381 ? 137.105 136.102 122.681 1.00 34.47  ? 381 ASP A O   1 
ATOM 2757 C CB  . ASP A 1 381 ? 135.892 133.701 121.748 1.00 36.57  ? 381 ASP A CB  1 
ATOM 2758 C CG  . ASP A 1 381 ? 135.198 133.619 123.101 1.00 30.46  ? 381 ASP A CG  1 
ATOM 2759 O OD1 . ASP A 1 381 ? 134.118 134.225 123.260 1.00 30.77  ? 381 ASP A OD1 1 
ATOM 2760 O OD2 . ASP A 1 381 ? 135.725 132.939 124.006 1.00 30.11  ? 381 ASP A OD2 1 
ATOM 2761 N N   . TYR A 1 382 ? 135.451 137.334 121.802 1.00 24.90  ? 382 TYR A N   1 
ATOM 2762 C CA  . TYR A 1 382 ? 135.737 138.469 122.659 1.00 29.19  ? 382 TYR A CA  1 
ATOM 2763 C C   . TYR A 1 382 ? 135.178 138.221 124.059 1.00 37.14  ? 382 TYR A C   1 
ATOM 2764 O O   . TYR A 1 382 ? 134.361 137.324 124.281 1.00 44.21  ? 382 TYR A O   1 
ATOM 2765 C CB  . TYR A 1 382 ? 135.165 139.753 122.059 1.00 31.49  ? 382 TYR A CB  1 
ATOM 2766 C CG  . TYR A 1 382 ? 133.706 139.677 121.660 1.00 28.61  ? 382 TYR A CG  1 
ATOM 2767 C CD1 . TYR A 1 382 ? 132.703 139.979 122.571 1.00 33.51  ? 382 TYR A CD1 1 
ATOM 2768 C CD2 . TYR A 1 382 ? 133.333 139.326 120.369 1.00 25.70  ? 382 TYR A CD2 1 
ATOM 2769 C CE1 . TYR A 1 382 ? 131.372 139.917 122.216 1.00 39.56  ? 382 TYR A CE1 1 
ATOM 2770 C CE2 . TYR A 1 382 ? 132.002 139.262 120.005 1.00 38.40  ? 382 TYR A CE2 1 
ATOM 2771 C CZ  . TYR A 1 382 ? 131.028 139.559 120.934 1.00 38.46  ? 382 TYR A CZ  1 
ATOM 2772 O OH  . TYR A 1 382 ? 129.701 139.501 120.586 1.00 17.50  ? 382 TYR A OH  1 
ATOM 2773 N N   . SER A 1 383 ? 135.635 139.024 125.015 1.00 41.72  ? 383 SER A N   1 
ATOM 2774 C CA  . SER A 1 383 ? 135.177 138.880 126.387 1.00 43.24  ? 383 SER A CA  1 
ATOM 2775 C C   . SER A 1 383 ? 133.738 139.377 126.525 1.00 37.65  ? 383 SER A C   1 
ATOM 2776 O O   . SER A 1 383 ? 133.222 140.124 125.691 1.00 34.41  ? 383 SER A O   1 
ATOM 2777 C CB  . SER A 1 383 ? 136.101 139.630 127.343 1.00 41.93  ? 383 SER A CB  1 
ATOM 2778 O OG  . SER A 1 383 ? 136.218 140.993 126.978 1.00 36.41  ? 383 SER A OG  1 
ATOM 2779 N N   . LEU A 1 384 ? 133.086 138.953 127.604 1.00 40.32  ? 384 LEU A N   1 
ATOM 2780 C CA  . LEU A 1 384 ? 131.651 139.127 127.760 1.00 39.45  ? 384 LEU A CA  1 
ATOM 2781 C C   . LEU A 1 384 ? 131.325 139.952 128.999 1.00 48.00  ? 384 LEU A C   1 
ATOM 2782 O O   . LEU A 1 384 ? 132.013 139.877 130.021 1.00 45.60  ? 384 LEU A O   1 
ATOM 2783 C CB  . LEU A 1 384 ? 130.947 137.768 127.843 1.00 44.17  ? 384 LEU A CB  1 
ATOM 2784 C CG  . LEU A 1 384 ? 131.479 136.677 126.912 1.00 44.42  ? 384 LEU A CG  1 
ATOM 2785 C CD1 . LEU A 1 384 ? 130.861 135.333 127.253 1.00 43.85  ? 384 LEU A CD1 1 
ATOM 2786 C CD2 . LEU A 1 384 ? 131.217 137.034 125.459 1.00 40.09  ? 384 LEU A CD2 1 
ATOM 2787 N N   . ALA A 1 385 ? 130.261 140.745 128.884 1.00 39.17  ? 385 ALA A N   1 
ATOM 2788 C CA  . ALA A 1 385 ? 129.730 141.520 129.991 1.00 47.87  ? 385 ALA A CA  1 
ATOM 2789 C C   . ALA A 1 385 ? 129.031 140.594 130.989 1.00 37.90  ? 385 ALA A C   1 
ATOM 2790 O O   . ALA A 1 385 ? 128.616 139.491 130.627 1.00 39.01  ? 385 ALA A O   1 
ATOM 2791 C CB  . ALA A 1 385 ? 128.763 142.573 129.450 1.00 51.38  ? 385 ALA A CB  1 
ATOM 2792 N N   . PRO A 1 386 ? 128.882 141.010 132.268 1.00 42.44  ? 386 PRO A N   1 
ATOM 2793 C CA  . PRO A 1 386 ? 129.294 142.259 132.933 1.00 44.02  ? 386 PRO A CA  1 
ATOM 2794 C C   . PRO A 1 386 ? 130.657 142.209 133.608 1.00 52.28  ? 386 PRO A C   1 
ATOM 2795 O O   . PRO A 1 386 ? 131.173 143.246 134.016 1.00 58.88  ? 386 PRO A O   1 
ATOM 2796 C CB  . PRO A 1 386 ? 128.187 142.454 133.970 1.00 54.20  ? 386 PRO A CB  1 
ATOM 2797 C CG  . PRO A 1 386 ? 127.876 141.053 134.404 1.00 55.06  ? 386 PRO A CG  1 
ATOM 2798 C CD  . PRO A 1 386 ? 128.059 140.185 133.172 1.00 53.35  ? 386 PRO A CD  1 
ATOM 2799 N N   . GLU A 1 387 ? 131.257 141.027 133.756 1.00 72.60  ? 387 GLU A N   1 
ATOM 2800 C CA  . GLU A 1 387 ? 132.568 140.934 134.386 1.00 77.09  ? 387 GLU A CA  1 
ATOM 2801 C C   . GLU A 1 387 ? 133.664 141.531 133.517 1.00 69.29  ? 387 GLU A C   1 
ATOM 2802 O O   . GLU A 1 387 ? 134.706 141.936 134.042 1.00 64.19  ? 387 GLU A O   1 
ATOM 2803 C CB  . GLU A 1 387 ? 132.890 139.477 134.716 1.00 79.68  ? 387 GLU A CB  1 
ATOM 2804 C CG  . GLU A 1 387 ? 131.963 138.865 135.752 1.00 80.92  ? 387 GLU A CG  1 
ATOM 2805 C CD  . GLU A 1 387 ? 131.970 139.631 137.062 1.00 82.64  ? 387 GLU A CD  1 
ATOM 2806 O OE1 . GLU A 1 387 ? 133.070 139.953 137.559 1.00 81.10  ? 387 GLU A OE1 1 
ATOM 2807 O OE2 . GLU A 1 387 ? 130.875 139.913 137.593 1.00 81.20  ? 387 GLU A OE2 1 
ATOM 2808 N N   . ALA A 1 388 ? 133.450 141.599 132.206 1.00 60.16  ? 388 ALA A N   1 
ATOM 2809 C CA  . ALA A 1 388 ? 134.367 142.259 131.281 1.00 61.20  ? 388 ALA A CA  1 
ATOM 2810 C C   . ALA A 1 388 ? 133.560 143.202 130.398 1.00 69.33  ? 388 ALA A C   1 
ATOM 2811 O O   . ALA A 1 388 ? 133.294 142.903 129.226 1.00 67.78  ? 388 ALA A O   1 
ATOM 2812 C CB  . ALA A 1 388 ? 135.142 141.238 130.453 1.00 57.31  ? 388 ALA A CB  1 
ATOM 2813 N N   . PRO A 1 389 ? 133.155 144.361 130.929 1.00 63.40  ? 389 PRO A N   1 
ATOM 2814 C CA  . PRO A 1 389 ? 132.366 145.302 130.129 1.00 51.34  ? 389 PRO A CA  1 
ATOM 2815 C C   . PRO A 1 389 ? 133.252 146.152 129.238 1.00 51.23  ? 389 PRO A C   1 
ATOM 2816 O O   . PRO A 1 389 ? 134.448 145.878 129.109 1.00 55.65  ? 389 PRO A O   1 
ATOM 2817 C CB  . PRO A 1 389 ? 131.653 146.146 131.190 1.00 52.53  ? 389 PRO A CB  1 
ATOM 2818 C CG  . PRO A 1 389 ? 132.566 146.109 132.380 1.00 59.08  ? 389 PRO A CG  1 
ATOM 2819 C CD  . PRO A 1 389 ? 133.496 144.922 132.248 1.00 60.02  ? 389 PRO A CD  1 
ATOM 2820 N N   . PHE A 1 390 ? 132.675 147.162 128.595 1.00 54.74  ? 390 PHE A N   1 
ATOM 2821 C CA  . PHE A 1 390 ? 133.485 148.117 127.863 1.00 58.98  ? 390 PHE A CA  1 
ATOM 2822 C C   . PHE A 1 390 ? 134.375 148.890 128.840 1.00 56.67  ? 390 PHE A C   1 
ATOM 2823 O O   . PHE A 1 390 ? 133.988 149.133 129.986 1.00 59.01  ? 390 PHE A O   1 
ATOM 2824 C CB  . PHE A 1 390 ? 132.597 149.074 127.064 1.00 60.83  ? 390 PHE A CB  1 
ATOM 2825 C CG  . PHE A 1 390 ? 132.128 150.269 127.841 1.00 56.11  ? 390 PHE A CG  1 
ATOM 2826 C CD1 . PHE A 1 390 ? 132.619 151.532 127.553 1.00 60.75  ? 390 PHE A CD1 1 
ATOM 2827 C CD2 . PHE A 1 390 ? 131.192 150.133 128.852 1.00 51.30  ? 390 PHE A CD2 1 
ATOM 2828 C CE1 . PHE A 1 390 ? 132.194 152.633 128.265 1.00 60.10  ? 390 PHE A CE1 1 
ATOM 2829 C CE2 . PHE A 1 390 ? 130.762 151.230 129.568 1.00 54.08  ? 390 PHE A CE2 1 
ATOM 2830 C CZ  . PHE A 1 390 ? 131.264 152.481 129.273 1.00 58.58  ? 390 PHE A CZ  1 
ATOM 2831 N N   . PRO A 1 391 ? 135.590 149.262 128.424 1.00 42.28  ? 391 PRO A N   1 
ATOM 2832 C CA  . PRO A 1 391 ? 136.206 149.083 127.106 1.00 44.79  ? 391 PRO A CA  1 
ATOM 2833 C C   . PRO A 1 391 ? 136.993 147.782 126.941 1.00 56.70  ? 391 PRO A C   1 
ATOM 2834 O O   . PRO A 1 391 ? 137.621 147.599 125.903 1.00 62.60  ? 391 PRO A O   1 
ATOM 2835 C CB  . PRO A 1 391 ? 137.121 150.314 126.993 1.00 52.06  ? 391 PRO A CB  1 
ATOM 2836 C CG  . PRO A 1 391 ? 137.302 150.852 128.422 1.00 52.17  ? 391 PRO A CG  1 
ATOM 2837 C CD  . PRO A 1 391 ? 136.495 149.971 129.339 1.00 46.75  ? 391 PRO A CD  1 
ATOM 2838 N N   . ARG A 1 392 ? 136.995 146.873 127.922 1.00 57.15  ? 392 ARG A N   1 
ATOM 2839 C CA  . ARG A 1 392 ? 137.662 145.584 127.740 1.00 53.28  ? 392 ARG A CA  1 
ATOM 2840 C C   . ARG A 1 392 ? 136.985 144.762 126.650 1.00 58.92  ? 392 ARG A C   1 
ATOM 2841 O O   . ARG A 1 392 ? 137.660 144.132 125.829 1.00 61.88  ? 392 ARG A O   1 
ATOM 2842 C CB  . ARG A 1 392 ? 137.686 144.816 129.064 1.00 57.70  ? 392 ARG A CB  1 
ATOM 2843 C CG  . ARG A 1 392 ? 138.047 143.329 128.970 1.00 61.32  ? 392 ARG A CG  1 
ATOM 2844 C CD  . ARG A 1 392 ? 139.416 143.070 128.350 1.00 62.32  ? 392 ARG A CD  1 
ATOM 2845 N NE  . ARG A 1 392 ? 140.507 143.682 129.095 1.00 62.80  ? 392 ARG A NE  1 
ATOM 2846 C CZ  . ARG A 1 392 ? 141.331 143.012 129.887 1.00 57.20  ? 392 ARG A CZ  1 
ATOM 2847 N NH1 . ARG A 1 392 ? 141.194 141.711 130.084 1.00 58.34  ? 392 ARG A NH1 1 
ATOM 2848 N NH2 . ARG A 1 392 ? 142.322 143.660 130.490 1.00 59.32  ? 392 ARG A NH2 1 
ATOM 2849 N N   . ALA A 1 393 ? 135.653 144.779 126.610 1.00 56.02  ? 393 ALA A N   1 
ATOM 2850 C CA  . ALA A 1 393 ? 134.911 143.997 125.630 1.00 54.74  ? 393 ALA A CA  1 
ATOM 2851 C C   . ALA A 1 393 ? 135.057 144.520 124.204 1.00 48.84  ? 393 ALA A C   1 
ATOM 2852 O O   . ALA A 1 393 ? 134.658 143.819 123.270 1.00 36.65  ? 393 ALA A O   1 
ATOM 2853 C CB  . ALA A 1 393 ? 133.432 143.950 126.018 1.00 48.30  ? 393 ALA A CB  1 
ATOM 2854 N N   . LEU A 1 394 ? 135.607 145.720 124.010 1.00 43.60  ? 394 LEU A N   1 
ATOM 2855 C CA  . LEU A 1 394 ? 135.764 146.296 122.683 1.00 45.89  ? 394 LEU A CA  1 
ATOM 2856 C C   . LEU A 1 394 ? 137.218 146.465 122.265 1.00 47.08  ? 394 LEU A C   1 
ATOM 2857 O O   . LEU A 1 394 ? 137.475 146.850 121.119 1.00 52.72  ? 394 LEU A O   1 
ATOM 2858 C CB  . LEU A 1 394 ? 135.028 147.644 122.596 1.00 51.78  ? 394 LEU A CB  1 
ATOM 2859 C CG  . LEU A 1 394 ? 135.368 148.863 123.470 1.00 49.17  ? 394 LEU A CG  1 
ATOM 2860 C CD1 . LEU A 1 394 ? 136.532 149.709 122.951 1.00 50.19  ? 394 LEU A CD1 1 
ATOM 2861 C CD2 . LEU A 1 394 ? 134.130 149.730 123.649 1.00 49.08  ? 394 LEU A CD2 1 
ATOM 2862 N N   . GLU A 1 395 ? 138.174 146.193 123.150 1.00 43.72  ? 395 GLU A N   1 
ATOM 2863 C CA  . GLU A 1 395 ? 139.581 146.403 122.836 1.00 42.64  ? 395 GLU A CA  1 
ATOM 2864 C C   . GLU A 1 395 ? 140.312 145.126 122.448 1.00 44.02  ? 395 GLU A C   1 
ATOM 2865 O O   . GLU A 1 395 ? 141.236 145.183 121.630 1.00 44.13  ? 395 GLU A O   1 
ATOM 2866 C CB  . GLU A 1 395 ? 140.296 147.053 124.026 1.00 43.50  ? 395 GLU A CB  1 
ATOM 2867 C CG  . GLU A 1 395 ? 140.144 148.564 124.089 1.00 38.10  ? 395 GLU A CG  1 
ATOM 2868 C CD  . GLU A 1 395 ? 141.386 149.259 124.605 1.00 44.85  ? 395 GLU A CD  1 
ATOM 2869 O OE1 . GLU A 1 395 ? 142.402 148.573 124.835 1.00 46.03  ? 395 GLU A OE1 1 
ATOM 2870 O OE2 . GLU A 1 395 ? 141.344 150.493 124.789 1.00 39.97  ? 395 GLU A OE2 1 
ATOM 2871 N N   . GLU A 1 396 ? 139.937 143.976 123.015 1.00 41.33  ? 396 GLU A N   1 
ATOM 2872 C CA  . GLU A 1 396 ? 140.595 142.734 122.625 1.00 40.83  ? 396 GLU A CA  1 
ATOM 2873 C C   . GLU A 1 396 ? 140.120 142.260 121.259 1.00 36.53  ? 396 GLU A C   1 
ATOM 2874 O O   . GLU A 1 396 ? 140.859 141.563 120.557 1.00 42.73  ? 396 GLU A O   1 
ATOM 2875 C CB  . GLU A 1 396 ? 140.385 141.656 123.692 1.00 39.04  ? 396 GLU A CB  1 
ATOM 2876 C CG  . GLU A 1 396 ? 139.149 140.794 123.531 1.00 35.07  ? 396 GLU A CG  1 
ATOM 2877 C CD  . GLU A 1 396 ? 138.609 140.311 124.857 1.00 39.75  ? 396 GLU A CD  1 
ATOM 2878 O OE1 . GLU A 1 396 ? 138.570 141.115 125.811 1.00 40.70  ? 396 GLU A OE1 1 
ATOM 2879 O OE2 . GLU A 1 396 ? 138.230 139.125 124.944 1.00 42.89  ? 396 GLU A OE2 1 
ATOM 2880 N N   . CYS A 1 397 ? 138.898 142.620 120.863 1.00 34.23  ? 397 CYS A N   1 
ATOM 2881 C CA  . CYS A 1 397 ? 138.506 142.436 119.476 1.00 28.52  ? 397 CYS A CA  1 
ATOM 2882 C C   . CYS A 1 397 ? 139.060 143.544 118.601 1.00 26.77  ? 397 CYS A C   1 
ATOM 2883 O O   . CYS A 1 397 ? 139.136 143.377 117.380 1.00 28.72  ? 397 CYS A O   1 
ATOM 2884 C CB  . CYS A 1 397 ? 136.989 142.377 119.348 1.00 29.37  ? 397 CYS A CB  1 
ATOM 2885 S SG  . CYS A 1 397 ? 136.099 143.444 120.477 0.22 43.73  ? 397 CYS A SG  1 
ATOM 2886 N N   . PHE A 1 398 ? 139.429 144.678 119.197 1.00 31.66  ? 398 PHE A N   1 
ATOM 2887 C CA  . PHE A 1 398 ? 140.254 145.642 118.487 1.00 37.14  ? 398 PHE A CA  1 
ATOM 2888 C C   . PHE A 1 398 ? 141.698 145.174 118.392 1.00 46.64  ? 398 PHE A C   1 
ATOM 2889 O O   . PHE A 1 398 ? 142.373 145.484 117.407 1.00 41.81  ? 398 PHE A O   1 
ATOM 2890 C CB  . PHE A 1 398 ? 140.187 147.012 119.164 1.00 32.79  ? 398 PHE A CB  1 
ATOM 2891 C CG  . PHE A 1 398 ? 140.916 148.089 118.414 1.00 43.89  ? 398 PHE A CG  1 
ATOM 2892 C CD1 . PHE A 1 398 ? 140.808 148.188 117.033 1.00 43.36  ? 398 PHE A CD1 1 
ATOM 2893 C CD2 . PHE A 1 398 ? 141.720 148.993 119.085 1.00 43.45  ? 398 PHE A CD2 1 
ATOM 2894 C CE1 . PHE A 1 398 ? 141.485 149.169 116.339 1.00 40.67  ? 398 PHE A CE1 1 
ATOM 2895 C CE2 . PHE A 1 398 ? 142.397 149.977 118.397 1.00 35.91  ? 398 PHE A CE2 1 
ATOM 2896 C CZ  . PHE A 1 398 ? 142.280 150.065 117.022 1.00 34.26  ? 398 PHE A CZ  1 
ATOM 2897 N N   . PHE A 1 399 ? 142.183 144.426 119.380 1.00 45.88  ? 399 PHE A N   1 
ATOM 2898 C CA  . PHE A 1 399 ? 143.523 143.860 119.302 1.00 51.56  ? 399 PHE A CA  1 
ATOM 2899 C C   . PHE A 1 399 ? 143.599 142.695 118.318 1.00 51.48  ? 399 PHE A C   1 
ATOM 2900 O O   . PHE A 1 399 ? 144.556 142.605 117.541 1.00 54.28  ? 399 PHE A O   1 
ATOM 2901 C CB  . PHE A 1 399 ? 143.980 143.409 120.692 1.00 55.97  ? 399 PHE A CB  1 
ATOM 2902 C CG  . PHE A 1 399 ? 145.443 143.630 120.952 1.00 52.71  ? 399 PHE A CG  1 
ATOM 2903 C CD1 . PHE A 1 399 ? 145.975 144.908 120.937 1.00 50.51  ? 399 PHE A CD1 1 
ATOM 2904 C CD2 . PHE A 1 399 ? 146.282 142.563 121.225 1.00 49.58  ? 399 PHE A CD2 1 
ATOM 2905 C CE1 . PHE A 1 399 ? 147.317 145.119 121.174 1.00 50.96  ? 399 PHE A CE1 1 
ATOM 2906 C CE2 . PHE A 1 399 ? 147.624 142.770 121.466 1.00 50.68  ? 399 PHE A CE2 1 
ATOM 2907 C CZ  . PHE A 1 399 ? 148.141 144.050 121.443 1.00 48.35  ? 399 PHE A CZ  1 
ATOM 2908 N N   . ALA A 1 400 ? 142.598 141.807 118.334 1.00 43.66  ? 400 ALA A N   1 
ATOM 2909 C CA  . ALA A 1 400 ? 142.595 140.652 117.438 1.00 35.20  ? 400 ALA A CA  1 
ATOM 2910 C C   . ALA A 1 400 ? 142.437 141.071 115.986 1.00 37.40  ? 400 ALA A C   1 
ATOM 2911 O O   . ALA A 1 400 ? 143.056 140.479 115.096 1.00 32.27  ? 400 ALA A O   1 
ATOM 2912 C CB  . ALA A 1 400 ? 141.483 139.681 117.820 1.00 30.50  ? 400 ALA A CB  1 
ATOM 2913 N N   . TYR A 1 401 ? 141.590 142.067 115.724 1.00 48.79  ? 401 TYR A N   1 
ATOM 2914 C CA  . TYR A 1 401 ? 141.490 142.592 114.369 1.00 40.22  ? 401 TYR A CA  1 
ATOM 2915 C C   . TYR A 1 401 ? 142.791 143.266 113.956 1.00 31.65  ? 401 TYR A C   1 
ATOM 2916 O O   . TYR A 1 401 ? 143.214 143.145 112.803 1.00 44.04  ? 401 TYR A O   1 
ATOM 2917 C CB  . TYR A 1 401 ? 140.320 143.569 114.249 1.00 44.57  ? 401 TYR A CB  1 
ATOM 2918 C CG  . TYR A 1 401 ? 140.257 144.244 112.900 1.00 43.27  ? 401 TYR A CG  1 
ATOM 2919 C CD1 . TYR A 1 401 ? 140.232 145.627 112.791 1.00 45.88  ? 401 TYR A CD1 1 
ATOM 2920 C CD2 . TYR A 1 401 ? 140.233 143.493 111.730 1.00 37.06  ? 401 TYR A CD2 1 
ATOM 2921 C CE1 . TYR A 1 401 ? 140.185 146.242 111.555 1.00 45.47  ? 401 TYR A CE1 1 
ATOM 2922 C CE2 . TYR A 1 401 ? 140.186 144.099 110.494 1.00 35.30  ? 401 TYR A CE2 1 
ATOM 2923 C CZ  . TYR A 1 401 ? 140.162 145.471 110.413 1.00 43.77  ? 401 TYR A CZ  1 
ATOM 2924 O OH  . TYR A 1 401 ? 140.117 146.070 109.181 1.00 43.03  ? 401 TYR A OH  1 
ATOM 2925 N N   . CYS A 1 402 ? 143.444 143.964 114.892 1.00 30.65  ? 402 CYS A N   1 
ATOM 2926 C CA  . CYS A 1 402 ? 144.713 144.619 114.591 1.00 41.74  ? 402 CYS A CA  1 
ATOM 2927 C C   . CYS A 1 402 ? 145.834 143.614 114.361 1.00 50.64  ? 402 CYS A C   1 
ATOM 2928 O O   . CYS A 1 402 ? 146.750 143.876 113.573 1.00 48.38  ? 402 CYS A O   1 
ATOM 2929 C CB  . CYS A 1 402 ? 145.096 145.578 115.716 1.00 38.98  ? 402 CYS A CB  1 
ATOM 2930 S SG  . CYS A 1 402 ? 144.409 147.234 115.523 1.00 60.99  ? 402 CYS A SG  1 
ATOM 2931 N N   . TRP A 1 403 ? 145.791 142.472 115.044 1.00 55.67  ? 403 TRP A N   1 
ATOM 2932 C CA  . TRP A 1 403 ? 146.816 141.452 114.873 1.00 47.58  ? 403 TRP A CA  1 
ATOM 2933 C C   . TRP A 1 403 ? 146.681 140.704 113.551 1.00 52.67  ? 403 TRP A C   1 
ATOM 2934 O O   . TRP A 1 403 ? 147.648 140.076 113.107 1.00 53.60  ? 403 TRP A O   1 
ATOM 2935 C CB  . TRP A 1 403 ? 146.758 140.488 116.062 1.00 51.73  ? 403 TRP A CB  1 
ATOM 2936 C CG  . TRP A 1 403 ? 147.749 139.368 116.041 1.00 47.96  ? 403 TRP A CG  1 
ATOM 2937 C CD1 . TRP A 1 403 ? 149.043 139.405 116.471 1.00 52.91  ? 403 TRP A CD1 1 
ATOM 2938 C CD2 . TRP A 1 403 ? 147.514 138.033 115.589 1.00 48.28  ? 403 TRP A CD2 1 
ATOM 2939 N NE1 . TRP A 1 403 ? 149.632 138.176 116.304 1.00 51.26  ? 403 TRP A NE1 1 
ATOM 2940 C CE2 . TRP A 1 403 ? 148.713 137.316 115.763 1.00 48.51  ? 403 TRP A CE2 1 
ATOM 2941 C CE3 . TRP A 1 403 ? 146.407 137.375 115.047 1.00 54.37  ? 403 TRP A CE3 1 
ATOM 2942 C CZ2 . TRP A 1 403 ? 148.834 135.975 115.416 1.00 54.67  ? 403 TRP A CZ2 1 
ATOM 2943 C CZ3 . TRP A 1 403 ? 146.529 136.045 114.704 1.00 49.37  ? 403 TRP A CZ3 1 
ATOM 2944 C CH2 . TRP A 1 403 ? 147.733 135.359 114.889 1.00 52.23  ? 403 TRP A CH2 1 
ATOM 2945 N N   . ALA A 1 404 ? 145.528 140.791 112.893 1.00 63.66  ? 404 ALA A N   1 
ATOM 2946 C CA  . ALA A 1 404 ? 145.232 139.971 111.727 1.00 59.44  ? 404 ALA A CA  1 
ATOM 2947 C C   . ALA A 1 404 ? 145.515 140.656 110.393 1.00 56.25  ? 404 ALA A C   1 
ATOM 2948 O O   . ALA A 1 404 ? 145.209 140.070 109.351 1.00 56.40  ? 404 ALA A O   1 
ATOM 2949 C CB  . ALA A 1 404 ? 143.771 139.513 111.767 1.00 56.45  ? 404 ALA A CB  1 
ATOM 2950 N N   . ILE A 1 405 ? 146.074 141.869 110.378 1.00 59.53  ? 405 ILE A N   1 
ATOM 2951 C CA  . ILE A 1 405 ? 146.534 142.432 109.107 1.00 64.12  ? 405 ILE A CA  1 
ATOM 2952 C C   . ILE A 1 405 ? 148.027 142.175 108.908 1.00 66.50  ? 405 ILE A C   1 
ATOM 2953 O O   . ILE A 1 405 ? 148.526 142.268 107.776 1.00 65.26  ? 405 ILE A O   1 
ATOM 2954 C CB  . ILE A 1 405 ? 146.280 143.951 108.944 1.00 69.65  ? 405 ILE A CB  1 
ATOM 2955 C CG1 . ILE A 1 405 ? 144.832 144.366 109.207 1.00 64.87  ? 405 ILE A CG1 1 
ATOM 2956 C CG2 . ILE A 1 405 ? 146.580 144.419 107.520 1.00 72.64  ? 405 ILE A CG2 1 
ATOM 2957 C CD1 . ILE A 1 405 ? 144.568 144.823 110.617 1.00 62.75  ? 405 ILE A CD1 1 
ATOM 2958 N N   . LYS A 1 406 ? 148.753 141.840 109.968 1.00 68.00  ? 406 LYS A N   1 
ATOM 2959 C CA  . LYS A 1 406 ? 150.198 141.665 109.898 1.00 68.55  ? 406 LYS A CA  1 
ATOM 2960 C C   . LYS A 1 406 ? 150.603 140.204 109.984 1.00 68.92  ? 406 LYS A C   1 
ATOM 2961 O O   . LYS A 1 406 ? 151.526 139.777 109.287 1.00 65.60  ? 406 LYS A O   1 
ATOM 2962 C CB  . LYS A 1 406 ? 150.920 142.455 111.013 1.00 67.85  ? 406 LYS A CB  1 
ATOM 2963 C CG  . LYS A 1 406 ? 150.895 144.023 110.986 1.00 67.34  ? 406 LYS A CG  1 
ATOM 2964 C CD  . LYS A 1 406 ? 149.513 144.682 110.916 1.00 72.42  ? 406 LYS A CD  1 
ATOM 2965 C CE  . LYS A 1 406 ? 149.551 146.185 110.851 1.00 71.33  ? 406 LYS A CE  1 
ATOM 2966 N NZ  . LYS A 1 406 ? 148.161 146.734 110.855 1.00 68.08  ? 406 LYS A NZ  1 
ATOM 2967 N N   . HIS A 1 407 ? 149.917 139.432 110.821 1.00 65.41  ? 407 HIS A N   1 
ATOM 2968 C CA  . HIS A 1 407 ? 150.103 137.986 110.901 1.00 64.81  ? 407 HIS A CA  1 
ATOM 2969 C C   . HIS A 1 407 ? 149.100 137.285 109.981 1.00 64.36  ? 407 HIS A C   1 
ATOM 2970 O O   . HIS A 1 407 ? 148.323 136.422 110.385 1.00 66.14  ? 407 HIS A O   1 
ATOM 2971 C CB  . HIS A 1 407 ? 149.963 137.520 112.346 1.00 65.26  ? 407 HIS A CB  1 
ATOM 2972 C CG  . HIS A 1 407 ? 150.940 138.158 113.287 1.00 69.93  ? 407 HIS A CG  1 
ATOM 2973 N ND1 . HIS A 1 407 ? 151.971 137.459 113.877 1.00 72.86  ? 407 HIS A ND1 1 
ATOM 2974 C CD2 . HIS A 1 407 ? 151.043 139.431 113.739 1.00 69.30  ? 407 HIS A CD2 1 
ATOM 2975 C CE1 . HIS A 1 407 ? 152.666 138.273 114.652 1.00 67.50  ? 407 HIS A CE1 1 
ATOM 2976 N NE2 . HIS A 1 407 ? 152.124 139.475 114.586 1.00 66.80  ? 407 HIS A NE2 1 
ATOM 2977 N N   . CYS A 1 408 ? 149.121 137.705 108.715 1.00 61.08  ? 408 CYS A N   1 
ATOM 2978 C CA  . CYS A 1 408 ? 148.191 137.171 107.727 1.00 59.56  ? 408 CYS A CA  1 
ATOM 2979 C C   . CYS A 1 408 ? 148.571 135.764 107.287 1.00 70.88  ? 408 CYS A C   1 
ATOM 2980 O O   . CYS A 1 408 ? 147.696 134.904 107.136 1.00 74.53  ? 408 CYS A O   1 
ATOM 2981 C CB  . CYS A 1 408 ? 148.124 138.099 106.518 1.00 58.82  ? 408 CYS A CB  1 
ATOM 2982 S SG  . CYS A 1 408 ? 147.138 139.567 106.801 1.00 84.69  ? 408 CYS A SG  1 
ATOM 2983 N N   . ALA A 1 409 ? 149.863 135.515 107.055 1.00 70.00  ? 409 ALA A N   1 
ATOM 2984 C CA  . ALA A 1 409 ? 150.297 134.167 106.710 1.00 61.50  ? 409 ALA A CA  1 
ATOM 2985 C C   . ALA A 1 409 ? 150.137 133.219 107.888 1.00 58.54  ? 409 ALA A C   1 
ATOM 2986 O O   . ALA A 1 409 ? 149.905 132.022 107.692 1.00 61.12  ? 409 ALA A O   1 
ATOM 2987 C CB  . ALA A 1 409 ? 151.747 134.185 106.231 1.00 61.16  ? 409 ALA A CB  1 
ATOM 2988 N N   . LEU A 1 410 ? 150.245 133.742 109.111 1.00 55.77  ? 410 LEU A N   1 
ATOM 2989 C CA  . LEU A 1 410 ? 150.031 132.933 110.305 1.00 59.81  ? 410 LEU A CA  1 
ATOM 2990 C C   . LEU A 1 410 ? 148.582 132.472 110.414 1.00 54.50  ? 410 LEU A C   1 
ATOM 2991 O O   . LEU A 1 410 ? 148.315 131.401 110.969 1.00 53.15  ? 410 LEU A O   1 
ATOM 2992 C CB  . LEU A 1 410 ? 150.454 133.732 111.539 1.00 58.63  ? 410 LEU A CB  1 
ATOM 2993 C CG  . LEU A 1 410 ? 150.904 133.026 112.819 1.00 60.14  ? 410 LEU A CG  1 
ATOM 2994 C CD1 . LEU A 1 410 ? 151.797 133.955 113.620 1.00 57.64  ? 410 LEU A CD1 1 
ATOM 2995 C CD2 . LEU A 1 410 ? 149.724 132.605 113.665 1.00 56.93  ? 410 LEU A CD2 1 
ATOM 2996 N N   . LEU A 1 411 ? 147.641 133.258 109.895 1.00 46.18  ? 411 LEU A N   1 
ATOM 2997 C CA  . LEU A 1 411 ? 146.243 132.861 109.807 1.00 47.01  ? 411 LEU A CA  1 
ATOM 2998 C C   . LEU A 1 411 ? 145.891 132.255 108.455 1.00 42.20  ? 411 LEU A C   1 
ATOM 2999 O O   . LEU A 1 411 ? 144.720 131.950 108.211 1.00 42.01  ? 411 LEU A O   1 
ATOM 3000 C CB  . LEU A 1 411 ? 145.334 134.058 110.093 1.00 47.97  ? 411 LEU A CB  1 
ATOM 3001 C CG  . LEU A 1 411 ? 145.274 134.517 111.550 1.00 45.51  ? 411 LEU A CG  1 
ATOM 3002 C CD1 . LEU A 1 411 ? 144.576 135.858 111.657 1.00 48.79  ? 411 LEU A CD1 1 
ATOM 3003 C CD2 . LEU A 1 411 ? 144.568 133.479 112.401 1.00 35.62  ? 411 LEU A CD2 1 
ATOM 3004 N N   . GLY A 1 412 ? 146.875 132.066 107.584 1.00 36.29  ? 412 GLY A N   1 
ATOM 3005 C CA  . GLY A 1 412 ? 146.621 131.544 106.254 1.00 42.15  ? 412 GLY A CA  1 
ATOM 3006 C C   . GLY A 1 412 ? 145.860 132.488 105.352 1.00 43.27  ? 412 GLY A C   1 
ATOM 3007 O O   . GLY A 1 412 ? 145.005 132.042 104.577 1.00 45.58  ? 412 GLY A O   1 
ATOM 3008 N N   . SER A 1 413 ? 146.152 133.786 105.430 1.00 53.14  ? 413 SER A N   1 
ATOM 3009 C CA  . SER A 1 413 ? 145.495 134.779 104.589 1.00 56.76  ? 413 SER A CA  1 
ATOM 3010 C C   . SER A 1 413 ? 146.521 135.728 103.988 1.00 54.15  ? 413 SER A C   1 
ATOM 3011 O O   . SER A 1 413 ? 147.725 135.577 104.217 1.00 54.74  ? 413 SER A O   1 
ATOM 3012 C CB  . SER A 1 413 ? 144.459 135.566 105.391 1.00 47.73  ? 413 SER A CB  1 
ATOM 3013 O OG  . SER A 1 413 ? 145.059 136.677 106.032 1.00 48.70  ? 413 SER A OG  1 
ATOM 3014 N N   . THR A 1 414 ? 146.057 136.709 103.220 1.00 53.68  ? 414 THR A N   1 
ATOM 3015 C CA  . THR A 1 414 ? 146.930 137.703 102.612 1.00 59.03  ? 414 THR A CA  1 
ATOM 3016 C C   . THR A 1 414 ? 146.776 139.074 103.249 1.00 59.89  ? 414 THR A C   1 
ATOM 3017 O O   . THR A 1 414 ? 147.771 139.694 103.638 1.00 62.00  ? 414 THR A O   1 
ATOM 3018 C CB  . THR A 1 414 ? 146.658 137.794 101.105 1.00 61.78  ? 414 THR A CB  1 
ATOM 3019 O OG1 . THR A 1 414 ? 147.061 136.573 100.474 1.00 67.35  ? 414 THR A OG1 1 
ATOM 3020 C CG2 . THR A 1 414 ? 147.435 138.944 100.488 1.00 61.19  ? 414 THR A CG2 1 
ATOM 3021 N N   . GLY A 1 415 ? 145.545 139.563 103.372 1.00 69.09  ? 415 GLY A N   1 
ATOM 3022 C CA  . GLY A 1 415 ? 145.283 140.831 104.016 1.00 69.56  ? 415 GLY A CA  1 
ATOM 3023 C C   . GLY A 1 415 ? 145.108 142.010 103.087 1.00 70.32  ? 415 GLY A C   1 
ATOM 3024 O O   . GLY A 1 415 ? 144.949 143.137 103.572 1.00 70.05  ? 415 GLY A O   1 
ATOM 3025 N N   . GLU A 1 416 ? 145.134 141.794 101.771 1.00 79.33  ? 416 GLU A N   1 
ATOM 3026 C CA  . GLU A 1 416 ? 144.858 142.876 100.837 1.00 84.29  ? 416 GLU A CA  1 
ATOM 3027 C C   . GLU A 1 416 ? 143.373 143.186 100.725 1.00 81.43  ? 416 GLU A C   1 
ATOM 3028 O O   . GLU A 1 416 ? 143.012 144.190 100.102 1.00 84.70  ? 416 GLU A O   1 
ATOM 3029 C CB  . GLU A 1 416 ? 145.430 142.547 99.458  1.00 83.16  ? 416 GLU A CB  1 
ATOM 3030 C CG  . GLU A 1 416 ? 144.840 141.321 98.796  1.00 81.11  ? 416 GLU A CG  1 
ATOM 3031 C CD  . GLU A 1 416 ? 145.825 140.668 97.848  1.00 85.30  ? 416 GLU A CD  1 
ATOM 3032 O OE1 . GLU A 1 416 ? 147.001 141.088 97.840  1.00 84.86  ? 416 GLU A OE1 1 
ATOM 3033 O OE2 . GLU A 1 416 ? 145.433 139.737 97.115  1.00 84.77  ? 416 GLU A OE2 1 
ATOM 3034 N N   . ARG A 1 417 ? 142.511 142.355 101.305 1.00 61.24  ? 417 ARG A N   1 
ATOM 3035 C CA  . ARG A 1 417 ? 141.095 142.662 101.406 1.00 61.89  ? 417 ARG A CA  1 
ATOM 3036 C C   . ARG A 1 417 ? 140.526 142.001 102.650 1.00 67.72  ? 417 ARG A C   1 
ATOM 3037 O O   . ARG A 1 417 ? 140.804 140.833 102.924 1.00 74.52  ? 417 ARG A O   1 
ATOM 3038 C CB  . ARG A 1 417 ? 140.342 142.218 100.152 1.00 65.17  ? 417 ARG A CB  1 
ATOM 3039 C CG  . ARG A 1 417 ? 138.877 141.912 100.358 1.00 62.01  ? 417 ARG A CG  1 
ATOM 3040 C CD  . ARG A 1 417 ? 138.297 141.469 99.037  1.00 65.02  ? 417 ARG A CD  1 
ATOM 3041 N NE  . ARG A 1 417 ? 138.464 142.529 98.050  1.00 69.11  ? 417 ARG A NE  1 
ATOM 3042 C CZ  . ARG A 1 417 ? 137.697 143.608 97.947  1.00 65.34  ? 417 ARG A CZ  1 
ATOM 3043 N NH1 . ARG A 1 417 ? 136.504 143.670 98.516  1.00 61.55  ? 417 ARG A NH1 1 
ATOM 3044 N NH2 . ARG A 1 417 ? 138.122 144.639 97.224  1.00 62.94  ? 417 ARG A NH2 1 
ATOM 3045 N N   . ILE A 1 418 ? 139.745 142.763 103.406 1.00 44.27  ? 418 ILE A N   1 
ATOM 3046 C CA  . ILE A 1 418 ? 139.151 142.297 104.648 1.00 34.13  ? 418 ILE A CA  1 
ATOM 3047 C C   . ILE A 1 418 ? 137.640 142.344 104.501 1.00 26.08  ? 418 ILE A C   1 
ATOM 3048 O O   . ILE A 1 418 ? 137.094 143.272 103.896 1.00 52.05  ? 418 ILE A O   1 
ATOM 3049 C CB  . ILE A 1 418 ? 139.605 143.146 105.854 1.00 50.50  ? 418 ILE A CB  1 
ATOM 3050 C CG1 . ILE A 1 418 ? 141.072 143.569 105.701 1.00 55.74  ? 418 ILE A CG1 1 
ATOM 3051 C CG2 . ILE A 1 418 ? 139.376 142.397 107.164 1.00 45.41  ? 418 ILE A CG2 1 
ATOM 3052 C CD1 . ILE A 1 418 ? 142.075 142.462 105.939 1.00 45.08  ? 418 ILE A CD1 1 
ATOM 3053 N N   . CYS A 1 419 ? 136.969 141.334 105.040 1.00 18.39  ? 419 CYS A N   1 
ATOM 3054 C CA  . CYS A 1 419 ? 135.520 141.324 105.138 1.00 33.31  ? 419 CYS A CA  1 
ATOM 3055 C C   . CYS A 1 419 ? 135.141 141.254 106.609 1.00 28.51  ? 419 CYS A C   1 
ATOM 3056 O O   . CYS A 1 419 ? 135.997 141.088 107.481 1.00 34.48  ? 419 CYS A O   1 
ATOM 3057 C CB  . CYS A 1 419 ? 134.910 140.151 104.364 1.00 34.68  ? 419 CYS A CB  1 
ATOM 3058 S SG  . CYS A 1 419 ? 133.206 139.772 104.794 1.00 31.33  ? 419 CYS A SG  1 
ATOM 3059 N N   . LEU A 1 420 ? 133.850 141.397 106.886 1.00 20.40  ? 420 LEU A N   1 
ATOM 3060 C CA  . LEU A 1 420 ? 133.359 141.379 108.254 1.00 17.63  ? 420 LEU A CA  1 
ATOM 3061 C C   . LEU A 1 420 ? 132.042 140.626 108.337 1.00 23.64  ? 420 LEU A C   1 
ATOM 3062 O O   . LEU A 1 420 ? 131.363 140.395 107.335 1.00 37.70  ? 420 LEU A O   1 
ATOM 3063 C CB  . LEU A 1 420 ? 133.187 142.794 108.816 1.00 27.42  ? 420 LEU A CB  1 
ATOM 3064 C CG  . LEU A 1 420 ? 134.284 143.216 109.788 1.00 23.78  ? 420 LEU A CG  1 
ATOM 3065 C CD1 . LEU A 1 420 ? 134.172 144.672 110.162 1.00 17.84  ? 420 LEU A CD1 1 
ATOM 3066 C CD2 . LEU A 1 420 ? 134.177 142.359 111.016 1.00 13.59  ? 420 LEU A CD2 1 
ATOM 3067 N N   . ALA A 1 421 ? 131.696 140.240 109.561 1.00 16.79  ? 421 ALA A N   1 
ATOM 3068 C CA  . ALA A 1 421 ? 130.452 139.544 109.835 1.00 24.58  ? 421 ALA A CA  1 
ATOM 3069 C C   . ALA A 1 421 ? 129.909 140.016 111.172 1.00 15.30  ? 421 ALA A C   1 
ATOM 3070 O O   . ALA A 1 421 ? 130.647 140.495 112.035 1.00 1.00   ? 421 ALA A O   1 
ATOM 3071 C CB  . ALA A 1 421 ? 130.639 138.024 109.846 1.00 27.01  ? 421 ALA A CB  1 
ATOM 3072 N N   . GLY A 1 422 ? 128.601 139.868 111.332 1.00 28.03  ? 422 GLY A N   1 
ATOM 3073 C CA  . GLY A 1 422 ? 127.937 140.291 112.548 1.00 36.94  ? 422 GLY A CA  1 
ATOM 3074 C C   . GLY A 1 422 ? 126.819 139.333 112.882 1.00 44.70  ? 422 GLY A C   1 
ATOM 3075 O O   . GLY A 1 422 ? 126.407 138.511 112.058 1.00 33.87  ? 422 GLY A O   1 
ATOM 3076 N N   . ASP A 1 423 ? 126.322 139.459 114.106 1.00 51.00  ? 423 ASP A N   1 
ATOM 3077 C CA  . ASP A 1 423 ? 125.396 138.485 114.666 1.00 30.12  ? 423 ASP A CA  1 
ATOM 3078 C C   . ASP A 1 423 ? 124.383 139.241 115.517 1.00 25.40  ? 423 ASP A C   1 
ATOM 3079 O O   . ASP A 1 423 ? 124.196 140.451 115.346 1.00 21.91  ? 423 ASP A O   1 
ATOM 3080 C CB  . ASP A 1 423 ? 126.173 137.401 115.421 1.00 30.44  ? 423 ASP A CB  1 
ATOM 3081 C CG  . ASP A 1 423 ? 126.200 136.088 114.671 1.00 31.04  ? 423 ASP A CG  1 
ATOM 3082 O OD1 . ASP A 1 423 ? 125.922 136.093 113.456 1.00 36.50  ? 423 ASP A OD1 1 
ATOM 3083 O OD2 . ASP A 1 423 ? 126.526 135.055 115.281 1.00 31.82  ? 423 ASP A OD2 1 
ATOM 3084 N N   . SER A 1 424 ? 123.702 138.507 116.407 1.00 29.17  ? 424 SER A N   1 
ATOM 3085 C CA  . SER A 1 424 ? 122.564 139.022 117.170 1.00 40.26  ? 424 SER A CA  1 
ATOM 3086 C C   . SER A 1 424 ? 122.904 140.293 117.939 1.00 24.51  ? 424 SER A C   1 
ATOM 3087 O O   . SER A 1 424 ? 122.286 141.343 117.735 1.00 20.84  ? 424 SER A O   1 
ATOM 3088 C CB  . SER A 1 424 ? 122.064 137.945 118.134 1.00 32.88  ? 424 SER A CB  1 
ATOM 3089 O OG  . SER A 1 424 ? 121.394 138.530 119.235 1.00 23.07  ? 424 SER A OG  1 
ATOM 3090 N N   . ALA A 1 425 ? 123.888 140.217 118.825 1.00 24.66  ? 425 ALA A N   1 
ATOM 3091 C CA  . ALA A 1 425 ? 124.368 141.401 119.519 1.00 30.17  ? 425 ALA A CA  1 
ATOM 3092 C C   . ALA A 1 425 ? 125.662 141.943 118.940 1.00 30.91  ? 425 ALA A C   1 
ATOM 3093 O O   . ALA A 1 425 ? 125.905 143.150 119.018 1.00 29.96  ? 425 ALA A O   1 
ATOM 3094 C CB  . ALA A 1 425 ? 124.573 141.105 121.002 1.00 26.91  ? 425 ALA A CB  1 
ATOM 3095 N N   . GLY A 1 426 ? 126.477 141.092 118.323 1.00 37.05  ? 426 GLY A N   1 
ATOM 3096 C CA  . GLY A 1 426 ? 127.723 141.528 117.727 1.00 32.74  ? 426 GLY A CA  1 
ATOM 3097 C C   . GLY A 1 426 ? 127.550 142.219 116.391 1.00 27.74  ? 426 GLY A C   1 
ATOM 3098 O O   . GLY A 1 426 ? 128.271 141.926 115.433 1.00 30.49  ? 426 GLY A O   1 
ATOM 3099 N N   . GLY A 1 427 ? 126.591 143.134 116.314 1.00 20.18  ? 427 GLY A N   1 
ATOM 3100 C CA  . GLY A 1 427 ? 126.418 143.973 115.151 1.00 28.30  ? 427 GLY A CA  1 
ATOM 3101 C C   . GLY A 1 427 ? 126.864 145.386 115.453 1.00 26.17  ? 427 GLY A C   1 
ATOM 3102 O O   . GLY A 1 427 ? 127.455 146.047 114.598 1.00 27.85  ? 427 GLY A O   1 
ATOM 3103 N N   . ASN A 1 428 ? 126.594 145.860 116.672 1.00 19.91  ? 428 ASN A N   1 
ATOM 3104 C CA  . ASN A 1 428 ? 127.152 147.140 117.095 1.00 23.60  ? 428 ASN A CA  1 
ATOM 3105 C C   . ASN A 1 428 ? 128.657 147.030 117.298 1.00 38.73  ? 428 ASN A C   1 
ATOM 3106 O O   . ASN A 1 428 ? 129.398 147.979 117.019 1.00 33.54  ? 428 ASN A O   1 
ATOM 3107 C CB  . ASN A 1 428 ? 126.463 147.626 118.369 1.00 28.19  ? 428 ASN A CB  1 
ATOM 3108 C CG  . ASN A 1 428 ? 126.681 146.697 119.544 1.00 29.28  ? 428 ASN A CG  1 
ATOM 3109 O OD1 . ASN A 1 428 ? 127.702 146.770 120.225 1.00 29.99  ? 428 ASN A OD1 1 
ATOM 3110 N ND2 . ASN A 1 428 ? 125.726 145.810 119.782 1.00 31.14  ? 428 ASN A ND2 1 
ATOM 3111 N N   . LEU A 1 429 ? 129.124 145.875 117.781 1.00 46.51  ? 429 LEU A N   1 
ATOM 3112 C CA  . LEU A 1 429 ? 130.557 145.621 117.852 1.00 36.98  ? 429 LEU A CA  1 
ATOM 3113 C C   . LEU A 1 429 ? 131.147 145.422 116.466 1.00 21.24  ? 429 LEU A C   1 
ATOM 3114 O O   . LEU A 1 429 ? 132.338 145.661 116.258 1.00 31.88  ? 429 LEU A O   1 
ATOM 3115 C CB  . LEU A 1 429 ? 130.833 144.398 118.723 1.00 27.51  ? 429 LEU A CB  1 
ATOM 3116 C CG  . LEU A 1 429 ? 132.242 144.277 119.295 1.00 30.04  ? 429 LEU A CG  1 
ATOM 3117 C CD1 . LEU A 1 429 ? 132.711 145.609 119.850 1.00 34.77  ? 429 LEU A CD1 1 
ATOM 3118 C CD2 . LEU A 1 429 ? 132.286 143.207 120.365 1.00 32.79  ? 429 LEU A CD2 1 
ATOM 3119 N N   . CYS A 1 430 ? 130.332 144.969 115.515 1.00 16.41  ? 430 CYS A N   1 
ATOM 3120 C CA  . CYS A 1 430 ? 130.765 144.923 114.127 1.00 13.70  ? 430 CYS A CA  1 
ATOM 3121 C C   . CYS A 1 430 ? 130.906 146.324 113.543 1.00 21.03  ? 430 CYS A C   1 
ATOM 3122 O O   . CYS A 1 430 ? 131.804 146.568 112.730 1.00 27.82  ? 430 CYS A O   1 
ATOM 3123 C CB  . CYS A 1 430 ? 129.776 144.085 113.319 1.00 36.32  ? 430 CYS A CB  1 
ATOM 3124 S SG  . CYS A 1 430 ? 129.903 144.243 111.544 1.00 55.80  ? 430 CYS A SG  1 
ATOM 3125 N N   . PHE A 1 431 ? 130.038 147.253 113.948 1.00 38.23  ? 431 PHE A N   1 
ATOM 3126 C CA  . PHE A 1 431 ? 130.131 148.638 113.493 1.00 31.47  ? 431 PHE A CA  1 
ATOM 3127 C C   . PHE A 1 431 ? 131.267 149.388 114.172 1.00 33.20  ? 431 PHE A C   1 
ATOM 3128 O O   . PHE A 1 431 ? 132.004 150.130 113.514 1.00 35.29  ? 431 PHE A O   1 
ATOM 3129 C CB  . PHE A 1 431 ? 128.819 149.371 113.767 1.00 26.93  ? 431 PHE A CB  1 
ATOM 3130 C CG  . PHE A 1 431 ? 127.778 149.163 112.720 1.00 38.85  ? 431 PHE A CG  1 
ATOM 3131 C CD1 . PHE A 1 431 ? 127.989 149.580 111.422 1.00 32.58  ? 431 PHE A CD1 1 
ATOM 3132 C CD2 . PHE A 1 431 ? 126.580 148.552 113.038 1.00 39.58  ? 431 PHE A CD2 1 
ATOM 3133 C CE1 . PHE A 1 431 ? 127.025 149.385 110.468 1.00 22.84  ? 431 PHE A CE1 1 
ATOM 3134 C CE2 . PHE A 1 431 ? 125.621 148.347 112.086 1.00 30.69  ? 431 PHE A CE2 1 
ATOM 3135 C CZ  . PHE A 1 431 ? 125.839 148.769 110.803 1.00 22.03  ? 431 PHE A CZ  1 
ATOM 3136 N N   . THR A 1 432 ? 131.415 149.209 115.487 1.00 30.71  ? 432 THR A N   1 
ATOM 3137 C CA  . THR A 1 432 ? 132.283 150.083 116.269 1.00 28.95  ? 432 THR A CA  1 
ATOM 3138 C C   . THR A 1 432 ? 133.759 149.818 115.992 1.00 36.21  ? 432 THR A C   1 
ATOM 3139 O O   . THR A 1 432 ? 134.544 150.762 115.850 1.00 37.16  ? 432 THR A O   1 
ATOM 3140 C CB  . THR A 1 432 ? 131.976 149.918 117.753 1.00 27.14  ? 432 THR A CB  1 
ATOM 3141 O OG1 . THR A 1 432 ? 130.558 149.934 117.946 1.00 29.14  ? 432 THR A OG1 1 
ATOM 3142 C CG2 . THR A 1 432 ? 132.591 151.044 118.537 1.00 39.01  ? 432 THR A CG2 1 
ATOM 3143 N N   . VAL A 1 433 ? 134.159 148.547 115.904 1.00 41.56  ? 433 VAL A N   1 
ATOM 3144 C CA  . VAL A 1 433 ? 135.558 148.240 115.634 1.00 37.86  ? 433 VAL A CA  1 
ATOM 3145 C C   . VAL A 1 433 ? 135.928 148.527 114.187 1.00 44.04  ? 433 VAL A C   1 
ATOM 3146 O O   . VAL A 1 433 ? 137.117 148.597 113.860 1.00 37.99  ? 433 VAL A O   1 
ATOM 3147 C CB  . VAL A 1 433 ? 135.887 146.777 115.987 1.00 35.06  ? 433 VAL A CB  1 
ATOM 3148 C CG1 . VAL A 1 433 ? 135.322 146.417 117.347 1.00 37.05  ? 433 VAL A CG1 1 
ATOM 3149 C CG2 . VAL A 1 433 ? 135.375 145.833 114.915 1.00 36.33  ? 433 VAL A CG2 1 
ATOM 3150 N N   . ALA A 1 434 ? 134.947 148.697 113.309 1.00 35.80  ? 434 ALA A N   1 
ATOM 3151 C CA  . ALA A 1 434 ? 135.212 149.063 111.929 1.00 39.00  ? 434 ALA A CA  1 
ATOM 3152 C C   . ALA A 1 434 ? 135.135 150.562 111.702 1.00 36.52  ? 434 ALA A C   1 
ATOM 3153 O O   . ALA A 1 434 ? 135.275 151.011 110.560 1.00 38.01  ? 434 ALA A O   1 
ATOM 3154 C CB  . ALA A 1 434 ? 134.233 148.351 110.995 1.00 36.67  ? 434 ALA A CB  1 
ATOM 3155 N N   . LEU A 1 435 ? 134.918 151.344 112.754 1.00 29.26  ? 435 LEU A N   1 
ATOM 3156 C CA  . LEU A 1 435 ? 134.752 152.780 112.594 1.00 32.05  ? 435 LEU A CA  1 
ATOM 3157 C C   . LEU A 1 435 ? 135.766 153.532 113.446 1.00 43.91  ? 435 LEU A C   1 
ATOM 3158 O O   . LEU A 1 435 ? 136.251 154.594 113.044 1.00 45.21  ? 435 LEU A O   1 
ATOM 3159 C CB  . LEU A 1 435 ? 133.316 153.176 112.940 1.00 43.00  ? 435 LEU A CB  1 
ATOM 3160 C CG  . LEU A 1 435 ? 132.965 154.642 113.167 1.00 45.58  ? 435 LEU A CG  1 
ATOM 3161 C CD1 . LEU A 1 435 ? 133.153 155.437 111.889 1.00 50.47  ? 435 LEU A CD1 1 
ATOM 3162 C CD2 . LEU A 1 435 ? 131.532 154.752 113.658 1.00 42.63  ? 435 LEU A CD2 1 
ATOM 3163 N N   . ARG A 1 436 ? 136.111 152.986 114.614 1.00 56.38  ? 436 ARG A N   1 
ATOM 3164 C CA  . ARG A 1 436 ? 137.185 153.568 115.409 1.00 59.37  ? 436 ARG A CA  1 
ATOM 3165 C C   . ARG A 1 436 ? 138.559 153.273 114.829 1.00 48.76  ? 436 ARG A C   1 
ATOM 3166 O O   . ARG A 1 436 ? 139.526 153.951 115.192 1.00 52.26  ? 436 ARG A O   1 
ATOM 3167 C CB  . ARG A 1 436 ? 137.117 153.080 116.861 1.00 51.66  ? 436 ARG A CB  1 
ATOM 3168 C CG  . ARG A 1 436 ? 137.980 151.878 117.185 1.00 35.27  ? 436 ARG A CG  1 
ATOM 3169 C CD  . ARG A 1 436 ? 137.927 151.577 118.666 1.00 38.49  ? 436 ARG A CD  1 
ATOM 3170 N NE  . ARG A 1 436 ? 136.675 150.933 119.043 1.00 52.64  ? 436 ARG A NE  1 
ATOM 3171 C CZ  . ARG A 1 436 ? 136.449 149.629 118.963 1.00 55.81  ? 436 ARG A CZ  1 
ATOM 3172 N NH1 . ARG A 1 436 ? 137.374 148.793 118.523 1.00 60.22  ? 436 ARG A NH1 1 
ATOM 3173 N NH2 . ARG A 1 436 ? 135.267 149.150 119.341 1.00 48.66  ? 436 ARG A NH2 1 
ATOM 3174 N N   . ALA A 1 437 ? 138.665 152.285 113.939 1.00 54.96  ? 437 ALA A N   1 
ATOM 3175 C CA  . ALA A 1 437 ? 139.898 152.098 113.190 1.00 62.84  ? 437 ALA A CA  1 
ATOM 3176 C C   . ALA A 1 437 ? 140.148 153.261 112.240 1.00 59.64  ? 437 ALA A C   1 
ATOM 3177 O O   . ALA A 1 437 ? 141.305 153.628 112.004 1.00 60.58  ? 437 ALA A O   1 
ATOM 3178 C CB  . ALA A 1 437 ? 139.849 150.777 112.425 1.00 65.40  ? 437 ALA A CB  1 
ATOM 3179 N N   . ALA A 1 438 ? 139.082 153.857 111.695 1.00 52.65  ? 438 ALA A N   1 
ATOM 3180 C CA  . ALA A 1 438 ? 139.223 155.033 110.844 1.00 57.14  ? 438 ALA A CA  1 
ATOM 3181 C C   . ALA A 1 438 ? 139.688 156.255 111.621 1.00 62.43  ? 438 ALA A C   1 
ATOM 3182 O O   . ALA A 1 438 ? 140.240 157.182 111.021 1.00 71.65  ? 438 ALA A O   1 
ATOM 3183 C CB  . ALA A 1 438 ? 137.902 155.342 110.141 1.00 63.86  ? 438 ALA A CB  1 
ATOM 3184 N N   . ALA A 1 439 ? 139.470 156.280 112.935 1.00 61.10  ? 439 ALA A N   1 
ATOM 3185 C CA  . ALA A 1 439 ? 140.029 157.325 113.780 1.00 66.17  ? 439 ALA A CA  1 
ATOM 3186 C C   . ALA A 1 439 ? 141.519 157.139 114.035 1.00 69.43  ? 439 ALA A C   1 
ATOM 3187 O O   . ALA A 1 439 ? 142.165 158.067 114.532 1.00 66.57  ? 439 ALA A O   1 
ATOM 3188 C CB  . ALA A 1 439 ? 139.283 157.378 115.115 1.00 63.27  ? 439 ALA A CB  1 
ATOM 3189 N N   . TYR A 1 440 ? 142.074 155.970 113.710 1.00 82.50  ? 440 TYR A N   1 
ATOM 3190 C CA  . TYR A 1 440 ? 143.483 155.682 113.930 1.00 76.01  ? 440 TYR A CA  1 
ATOM 3191 C C   . TYR A 1 440 ? 144.307 155.710 112.651 1.00 74.79  ? 440 TYR A C   1 
ATOM 3192 O O   . TYR A 1 440 ? 145.539 155.696 112.728 1.00 75.14  ? 440 TYR A O   1 
ATOM 3193 C CB  . TYR A 1 440 ? 143.642 154.314 114.603 1.00 75.53  ? 440 TYR A CB  1 
ATOM 3194 C CG  . TYR A 1 440 ? 143.473 154.338 116.106 1.00 77.92  ? 440 TYR A CG  1 
ATOM 3195 C CD1 . TYR A 1 440 ? 143.032 155.481 116.762 1.00 81.78  ? 440 TYR A CD1 1 
ATOM 3196 C CD2 . TYR A 1 440 ? 143.741 153.211 116.868 1.00 68.92  ? 440 TYR A CD2 1 
ATOM 3197 C CE1 . TYR A 1 440 ? 142.874 155.501 118.136 1.00 82.10  ? 440 TYR A CE1 1 
ATOM 3198 C CE2 . TYR A 1 440 ? 143.589 153.222 118.240 1.00 68.44  ? 440 TYR A CE2 1 
ATOM 3199 C CZ  . TYR A 1 440 ? 143.154 154.367 118.868 1.00 77.53  ? 440 TYR A CZ  1 
ATOM 3200 O OH  . TYR A 1 440 ? 142.999 154.376 120.235 1.00 78.61  ? 440 TYR A OH  1 
ATOM 3201 N N   . GLY A 1 441 ? 143.664 155.752 111.484 1.00 71.17  ? 441 GLY A N   1 
ATOM 3202 C CA  . GLY A 1 441 ? 144.359 155.795 110.217 1.00 73.66  ? 441 GLY A CA  1 
ATOM 3203 C C   . GLY A 1 441 ? 144.643 154.448 109.588 1.00 79.16  ? 441 GLY A C   1 
ATOM 3204 O O   . GLY A 1 441 ? 145.079 154.404 108.433 1.00 81.38  ? 441 GLY A O   1 
ATOM 3205 N N   . VAL A 1 442 ? 144.414 153.349 110.307 1.00 71.50  ? 442 VAL A N   1 
ATOM 3206 C CA  . VAL A 1 442 ? 144.613 152.021 109.740 1.00 63.58  ? 442 VAL A CA  1 
ATOM 3207 C C   . VAL A 1 442 ? 143.486 151.722 108.752 1.00 66.53  ? 442 VAL A C   1 
ATOM 3208 O O   . VAL A 1 442 ? 142.350 152.187 108.914 1.00 72.65  ? 442 VAL A O   1 
ATOM 3209 C CB  . VAL A 1 442 ? 144.697 150.984 110.880 1.00 64.50  ? 442 VAL A CB  1 
ATOM 3210 C CG1 . VAL A 1 442 ? 143.491 151.089 111.798 1.00 65.06  ? 442 VAL A CG1 1 
ATOM 3211 C CG2 . VAL A 1 442 ? 144.891 149.555 110.367 1.00 69.66  ? 442 VAL A CG2 1 
ATOM 3212 N N   . ARG A 1 443 ? 143.819 150.985 107.688 1.00 56.39  ? 443 ARG A N   1 
ATOM 3213 C CA  . ARG A 1 443 ? 142.883 150.643 106.621 1.00 57.21  ? 443 ARG A CA  1 
ATOM 3214 C C   . ARG A 1 443 ? 141.667 149.888 107.142 1.00 57.54  ? 443 ARG A C   1 
ATOM 3215 O O   . ARG A 1 443 ? 141.780 148.750 107.609 1.00 51.42  ? 443 ARG A O   1 
ATOM 3216 C CB  . ARG A 1 443 ? 143.593 149.811 105.550 1.00 60.30  ? 443 ARG A CB  1 
ATOM 3217 C CG  . ARG A 1 443 ? 145.089 150.059 105.484 1.00 62.87  ? 443 ARG A CG  1 
ATOM 3218 C CD  . ARG A 1 443 ? 145.762 149.234 104.392 1.00 58.30  ? 443 ARG A CD  1 
ATOM 3219 N NE  . ARG A 1 443 ? 147.198 149.080 104.608 1.00 55.88  ? 443 ARG A NE  1 
ATOM 3220 C CZ  . ARG A 1 443 ? 148.099 150.050 104.508 1.00 59.65  ? 443 ARG A CZ  1 
ATOM 3221 N NH1 . ARG A 1 443 ? 147.765 151.273 104.127 1.00 58.11  ? 443 ARG A NH1 1 
ATOM 3222 N NH2 . ARG A 1 443 ? 149.372 149.783 104.781 1.00 55.16  ? 443 ARG A NH2 1 
ATOM 3223 N N   . VAL A 1 444 ? 140.503 150.526 107.068 1.00 52.14  ? 444 VAL A N   1 
ATOM 3224 C CA  . VAL A 1 444 ? 139.239 149.960 107.533 1.00 48.96  ? 444 VAL A CA  1 
ATOM 3225 C C   . VAL A 1 444 ? 138.745 148.943 106.511 1.00 41.27  ? 444 VAL A C   1 
ATOM 3226 O O   . VAL A 1 444 ? 139.147 149.010 105.340 1.00 41.99  ? 444 VAL A O   1 
ATOM 3227 C CB  . VAL A 1 444 ? 138.203 151.072 107.772 1.00 50.77  ? 444 VAL A CB  1 
ATOM 3228 C CG1 . VAL A 1 444 ? 138.617 151.917 108.948 1.00 47.89  ? 444 VAL A CG1 1 
ATOM 3229 C CG2 . VAL A 1 444 ? 138.045 151.927 106.525 1.00 51.16  ? 444 VAL A CG2 1 
ATOM 3230 N N   . PRO A 1 445 ? 137.897 147.986 106.890 1.00 35.29  ? 445 PRO A N   1 
ATOM 3231 C CA  . PRO A 1 445 ? 137.319 147.085 105.891 1.00 37.63  ? 445 PRO A CA  1 
ATOM 3232 C C   . PRO A 1 445 ? 136.361 147.829 104.979 1.00 44.54  ? 445 PRO A C   1 
ATOM 3233 O O   . PRO A 1 445 ? 135.950 148.959 105.248 1.00 49.50  ? 445 PRO A O   1 
ATOM 3234 C CB  . PRO A 1 445 ? 136.582 146.041 106.733 1.00 32.06  ? 445 PRO A CB  1 
ATOM 3235 C CG  . PRO A 1 445 ? 136.293 146.730 108.002 1.00 36.68  ? 445 PRO A CG  1 
ATOM 3236 C CD  . PRO A 1 445 ? 137.455 147.629 108.250 1.00 40.31  ? 445 PRO A CD  1 
ATOM 3237 N N   . ASP A 1 446 ? 136.021 147.183 103.868 1.00 43.65  ? 446 ASP A N   1 
ATOM 3238 C CA  . ASP A 1 446 ? 135.125 147.771 102.885 1.00 42.76  ? 446 ASP A CA  1 
ATOM 3239 C C   . ASP A 1 446 ? 133.750 147.115 102.884 1.00 47.01  ? 446 ASP A C   1 
ATOM 3240 O O   . ASP A 1 446 ? 133.031 147.196 101.882 1.00 45.49  ? 446 ASP A O   1 
ATOM 3241 C CB  . ASP A 1 446 ? 135.753 147.698 101.496 1.00 45.76  ? 446 ASP A CB  1 
ATOM 3242 C CG  . ASP A 1 446 ? 135.803 146.293 100.963 1.00 47.76  ? 446 ASP A CG  1 
ATOM 3243 O OD1 . ASP A 1 446 ? 136.123 145.375 101.746 1.00 46.15  ? 446 ASP A OD1 1 
ATOM 3244 O OD2 . ASP A 1 446 ? 135.519 146.097 99.763  1.00 54.49  ? 446 ASP A OD2 1 
ATOM 3245 N N   . GLY A 1 447 ? 133.366 146.476 103.983 1.00 46.18  ? 447 GLY A N   1 
ATOM 3246 C CA  . GLY A 1 447 ? 132.047 145.882 104.066 1.00 47.22  ? 447 GLY A CA  1 
ATOM 3247 C C   . GLY A 1 447 ? 131.654 145.598 105.494 1.00 43.98  ? 447 GLY A C   1 
ATOM 3248 O O   . GLY A 1 447 ? 132.504 145.387 106.364 1.00 43.47  ? 447 GLY A O   1 
ATOM 3249 N N   . ILE A 1 448 ? 130.347 145.605 105.733 1.00 45.13  ? 448 ILE A N   1 
ATOM 3250 C CA  . ILE A 1 448 ? 129.756 145.287 107.025 1.00 37.37  ? 448 ILE A CA  1 
ATOM 3251 C C   . ILE A 1 448 ? 128.562 144.385 106.757 1.00 34.21  ? 448 ILE A C   1 
ATOM 3252 O O   . ILE A 1 448 ? 127.711 144.715 105.923 1.00 38.04  ? 448 ILE A O   1 
ATOM 3253 C CB  . ILE A 1 448 ? 129.317 146.552 107.782 1.00 49.04  ? 448 ILE A CB  1 
ATOM 3254 C CG1 . ILE A 1 448 ? 130.526 147.375 108.233 1.00 37.94  ? 448 ILE A CG1 1 
ATOM 3255 C CG2 . ILE A 1 448 ? 128.411 146.204 108.952 1.00 43.10  ? 448 ILE A CG2 1 
ATOM 3256 C CD1 . ILE A 1 448 ? 131.215 146.849 109.449 1.00 28.52  ? 448 ILE A CD1 1 
ATOM 3257 N N   . MET A 1 449 ? 128.497 143.250 107.444 1.00 18.90  ? 449 MET A N   1 
ATOM 3258 C CA  . MET A 1 449 ? 127.345 142.359 107.357 1.00 26.91  ? 449 MET A CA  1 
ATOM 3259 C C   . MET A 1 449 ? 126.939 142.063 108.796 1.00 33.04  ? 449 MET A C   1 
ATOM 3260 O O   . MET A 1 449 ? 127.445 141.125 109.413 1.00 32.59  ? 449 MET A O   1 
ATOM 3261 C CB  . MET A 1 449 ? 127.675 141.088 106.570 1.00 26.39  ? 449 MET A CB  1 
ATOM 3262 C CG  . MET A 1 449 ? 126.484 140.343 105.944 1.00 34.10  ? 449 MET A CG  1 
ATOM 3263 S SD  . MET A 1 449 ? 125.024 140.040 106.959 1.00 49.54  ? 449 MET A SD  1 
ATOM 3264 C CE  . MET A 1 449 ? 125.626 138.742 108.033 1.00 38.87  ? 449 MET A CE  1 
ATOM 3265 N N   . ALA A 1 450 ? 126.025 142.868 109.325 1.00 29.71  ? 450 ALA A N   1 
ATOM 3266 C CA  . ALA A 1 450 ? 125.485 142.681 110.663 1.00 24.06  ? 450 ALA A CA  1 
ATOM 3267 C C   . ALA A 1 450 ? 124.012 142.327 110.555 1.00 36.24  ? 450 ALA A C   1 
ATOM 3268 O O   . ALA A 1 450 ? 123.231 143.080 109.965 1.00 31.68  ? 450 ALA A O   1 
ATOM 3269 C CB  . ALA A 1 450 ? 125.669 143.936 111.516 1.00 27.13  ? 450 ALA A CB  1 
ATOM 3270 N N   . ALA A 1 451 ? 123.637 141.188 111.125 1.00 38.37  ? 451 ALA A N   1 
ATOM 3271 C CA  . ALA A 1 451 ? 122.264 140.706 111.090 1.00 30.84  ? 451 ALA A CA  1 
ATOM 3272 C C   . ALA A 1 451 ? 121.573 141.045 112.402 1.00 25.28  ? 451 ALA A C   1 
ATOM 3273 O O   . ALA A 1 451 ? 122.024 140.615 113.468 1.00 24.87  ? 451 ALA A O   1 
ATOM 3274 C CB  . ALA A 1 451 ? 122.224 139.198 110.848 1.00 31.17  ? 451 ALA A CB  1 
ATOM 3275 N N   . TYR A 1 452 ? 120.441 141.762 112.305 1.00 25.73  ? 452 TYR A N   1 
ATOM 3276 C CA  . TYR A 1 452 ? 119.597 142.301 113.376 1.00 33.62  ? 452 TYR A CA  1 
ATOM 3277 C C   . TYR A 1 452 ? 120.407 142.807 114.572 1.00 38.79  ? 452 TYR A C   1 
ATOM 3278 O O   . TYR A 1 452 ? 120.357 142.218 115.658 1.00 43.01  ? 452 TYR A O   1 
ATOM 3279 C CB  . TYR A 1 452 ? 118.527 141.284 113.822 1.00 32.41  ? 452 TYR A CB  1 
ATOM 3280 C CG  . TYR A 1 452 ? 118.961 139.871 114.190 1.00 29.58  ? 452 TYR A CG  1 
ATOM 3281 C CD1 . TYR A 1 452 ? 119.264 138.926 113.214 1.00 36.43  ? 452 TYR A CD1 1 
ATOM 3282 C CD2 . TYR A 1 452 ? 118.991 139.461 115.517 1.00 25.00  ? 452 TYR A CD2 1 
ATOM 3283 C CE1 . TYR A 1 452 ? 119.650 137.649 113.552 1.00 30.84  ? 452 TYR A CE1 1 
ATOM 3284 C CE2 . TYR A 1 452 ? 119.360 138.180 115.860 1.00 27.89  ? 452 TYR A CE2 1 
ATOM 3285 C CZ  . TYR A 1 452 ? 119.689 137.279 114.874 1.00 29.22  ? 452 TYR A CZ  1 
ATOM 3286 O OH  . TYR A 1 452 ? 120.063 136.001 115.212 1.00 21.96  ? 452 TYR A OH  1 
ATOM 3287 N N   . PRO A 1 453 ? 121.155 143.894 114.415 1.00 23.03  ? 453 PRO A N   1 
ATOM 3288 C CA  . PRO A 1 453 ? 122.062 144.338 115.475 1.00 18.63  ? 453 PRO A CA  1 
ATOM 3289 C C   . PRO A 1 453 ? 121.336 145.116 116.565 1.00 12.21  ? 453 PRO A C   1 
ATOM 3290 O O   . PRO A 1 453 ? 120.231 145.624 116.383 1.00 29.84  ? 453 PRO A O   1 
ATOM 3291 C CB  . PRO A 1 453 ? 123.037 145.237 114.721 1.00 29.23  ? 453 PRO A CB  1 
ATOM 3292 C CG  . PRO A 1 453 ? 122.201 145.834 113.659 1.00 19.25  ? 453 PRO A CG  1 
ATOM 3293 C CD  . PRO A 1 453 ? 121.186 144.803 113.259 1.00 14.11  ? 453 PRO A CD  1 
ATOM 3294 N N   . ALA A 1 454 ? 121.996 145.200 117.721 1.00 20.25  ? 454 ALA A N   1 
ATOM 3295 C CA  . ALA A 1 454 ? 121.497 145.961 118.867 1.00 36.50  ? 454 ALA A CA  1 
ATOM 3296 C C   . ALA A 1 454 ? 122.190 147.319 118.858 1.00 45.60  ? 454 ALA A C   1 
ATOM 3297 O O   . ALA A 1 454 ? 123.134 147.577 119.603 1.00 38.82  ? 454 ALA A O   1 
ATOM 3298 C CB  . ALA A 1 454 ? 121.743 145.205 120.169 1.00 35.98  ? 454 ALA A CB  1 
ATOM 3299 N N   . THR A 1 455 ? 121.703 148.204 117.997 1.00 47.80  ? 455 THR A N   1 
ATOM 3300 C CA  . THR A 1 455 ? 122.457 149.395 117.642 1.00 38.59  ? 455 THR A CA  1 
ATOM 3301 C C   . THR A 1 455 ? 121.949 150.618 118.427 1.00 39.32  ? 455 THR A C   1 
ATOM 3302 O O   . THR A 1 455 ? 122.529 151.708 118.353 1.00 42.80  ? 455 THR A O   1 
ATOM 3303 C CB  . THR A 1 455 ? 122.361 149.548 116.115 1.00 37.95  ? 455 THR A CB  1 
ATOM 3304 O OG1 . THR A 1 455 ? 122.884 148.355 115.532 1.00 39.77  ? 455 THR A OG1 1 
ATOM 3305 C CG2 . THR A 1 455 ? 123.332 150.579 115.605 1.00 38.31  ? 455 THR A CG2 1 
ATOM 3306 N N   . MET A 1 456 ? 120.937 150.402 119.268 1.00 47.38  ? 456 MET A N   1 
ATOM 3307 C CA  . MET A 1 456 ? 120.212 151.407 120.058 1.00 49.27  ? 456 MET A CA  1 
ATOM 3308 C C   . MET A 1 456 ? 120.161 151.014 121.529 1.00 53.84  ? 456 MET A C   1 
ATOM 3309 O O   . MET A 1 456 ? 119.101 150.970 122.151 1.00 52.17  ? 456 MET A O   1 
ATOM 3310 C CB  . MET A 1 456 ? 118.818 151.639 119.489 1.00 54.78  ? 456 MET A CB  1 
ATOM 3311 C CG  . MET A 1 456 ? 118.737 152.750 118.483 1.00 53.76  ? 456 MET A CG  1 
ATOM 3312 S SD  . MET A 1 456 ? 119.584 154.086 119.361 1.00 52.36  ? 456 MET A SD  1 
ATOM 3313 C CE  . MET A 1 456 ? 119.579 155.429 118.254 1.00 54.38  ? 456 MET A CE  1 
ATOM 3314 N N   . LEU A 1 457 ? 121.339 150.729 122.085 1.00 56.37  ? 457 LEU A N   1 
ATOM 3315 C CA  . LEU A 1 457 ? 121.463 150.369 123.494 1.00 52.77  ? 457 LEU A CA  1 
ATOM 3316 C C   . LEU A 1 457 ? 121.009 151.480 124.439 1.00 55.44  ? 457 LEU A C   1 
ATOM 3317 O O   . LEU A 1 457 ? 120.756 151.206 125.616 1.00 54.98  ? 457 LEU A O   1 
ATOM 3318 C CB  . LEU A 1 457 ? 122.910 149.985 123.790 1.00 51.68  ? 457 LEU A CB  1 
ATOM 3319 C CG  . LEU A 1 457 ? 123.316 148.605 123.274 1.00 52.24  ? 457 LEU A CG  1 
ATOM 3320 C CD1 . LEU A 1 457 ? 124.822 148.510 123.087 1.00 46.15  ? 457 LEU A CD1 1 
ATOM 3321 C CD2 . LEU A 1 457 ? 122.812 147.518 124.214 1.00 54.91  ? 457 LEU A CD2 1 
ATOM 3322 N N   . GLN A 1 458 ? 120.921 152.719 123.967 1.00 63.83  ? 458 GLN A N   1 
ATOM 3323 C CA  . GLN A 1 458 ? 120.290 153.783 124.739 1.00 67.55  ? 458 GLN A CA  1 
ATOM 3324 C C   . GLN A 1 458 ? 118.810 153.464 124.933 1.00 65.75  ? 458 GLN A C   1 
ATOM 3325 O O   . GLN A 1 458 ? 118.103 153.229 123.941 1.00 60.76  ? 458 GLN A O   1 
ATOM 3326 C CB  . GLN A 1 458 ? 120.460 155.123 124.024 1.00 64.33  ? 458 GLN A CB  1 
ATOM 3327 C CG  . GLN A 1 458 ? 119.455 156.192 124.417 1.00 61.22  ? 458 GLN A CG  1 
ATOM 3328 C CD  . GLN A 1 458 ? 120.050 157.260 125.306 1.00 66.33  ? 458 GLN A CD  1 
ATOM 3329 O OE1 . GLN A 1 458 ? 121.183 157.139 125.767 1.00 69.62  ? 458 GLN A OE1 1 
ATOM 3330 N NE2 . GLN A 1 458 ? 119.289 158.320 125.544 1.00 69.66  ? 458 GLN A NE2 1 
ATOM 3331 N N   . PRO A 1 459 ? 118.306 153.422 126.170 1.00 78.02  ? 459 PRO A N   1 
ATOM 3332 C CA  . PRO A 1 459 ? 116.905 153.031 126.398 1.00 79.42  ? 459 PRO A CA  1 
ATOM 3333 C C   . PRO A 1 459 ? 115.934 154.128 125.980 1.00 85.24  ? 459 PRO A C   1 
ATOM 3334 O O   . PRO A 1 459 ? 116.032 155.271 126.431 1.00 78.70  ? 459 PRO A O   1 
ATOM 3335 C CB  . PRO A 1 459 ? 116.859 152.778 127.912 1.00 77.63  ? 459 PRO A CB  1 
ATOM 3336 C CG  . PRO A 1 459 ? 117.933 153.696 128.442 1.00 78.50  ? 459 PRO A CG  1 
ATOM 3337 C CD  . PRO A 1 459 ? 119.043 153.485 127.444 1.00 80.45  ? 459 PRO A CD  1 
ATOM 3338 N N   . ALA A 1 460 ? 114.991 153.772 125.108 1.00 89.04  ? 460 ALA A N   1 
ATOM 3339 C CA  . ALA A 1 460 ? 113.966 154.705 124.661 1.00 86.47  ? 460 ALA A CA  1 
ATOM 3340 C C   . ALA A 1 460 ? 112.776 153.920 124.129 1.00 87.42  ? 460 ALA A C   1 
ATOM 3341 O O   . ALA A 1 460 ? 112.937 152.811 123.613 1.00 85.07  ? 460 ALA A O   1 
ATOM 3342 C CB  . ALA A 1 460 ? 114.500 155.656 123.584 1.00 88.51  ? 460 ALA A CB  1 
ATOM 3343 N N   . ALA A 1 461 ? 111.587 154.503 124.259 1.00 88.30  ? 461 ALA A N   1 
ATOM 3344 C CA  . ALA A 1 461 ? 110.378 153.865 123.764 1.00 88.41  ? 461 ALA A CA  1 
ATOM 3345 C C   . ALA A 1 461 ? 110.303 153.956 122.244 1.00 83.72  ? 461 ALA A C   1 
ATOM 3346 O O   . ALA A 1 461 ? 110.788 154.906 121.624 1.00 83.80  ? 461 ALA A O   1 
ATOM 3347 C CB  . ALA A 1 461 ? 109.139 154.506 124.386 1.00 84.03  ? 461 ALA A CB  1 
ATOM 3348 N N   . SER A 1 462 ? 109.681 152.947 121.644 1.00 61.08  ? 462 SER A N   1 
ATOM 3349 C CA  . SER A 1 462 ? 109.555 152.868 120.196 1.00 62.18  ? 462 SER A CA  1 
ATOM 3350 C C   . SER A 1 462 ? 108.369 151.973 119.866 1.00 67.17  ? 462 SER A C   1 
ATOM 3351 O O   . SER A 1 462 ? 107.991 151.123 120.680 1.00 70.39  ? 462 SER A O   1 
ATOM 3352 C CB  . SER A 1 462 ? 110.844 152.325 119.560 1.00 64.27  ? 462 SER A CB  1 
ATOM 3353 O OG  . SER A 1 462 ? 111.889 153.275 119.650 1.00 72.96  ? 462 SER A OG  1 
ATOM 3354 N N   . PRO A 1 463 ? 107.743 152.160 118.694 1.00 61.48  ? 463 PRO A N   1 
ATOM 3355 C CA  . PRO A 1 463 ? 106.622 151.278 118.316 1.00 56.01  ? 463 PRO A CA  1 
ATOM 3356 C C   . PRO A 1 463 ? 107.008 149.818 118.172 1.00 56.59  ? 463 PRO A C   1 
ATOM 3357 O O   . PRO A 1 463 ? 106.224 148.936 118.541 1.00 56.13  ? 463 PRO A O   1 
ATOM 3358 C CB  . PRO A 1 463 ? 106.160 151.856 116.972 1.00 49.65  ? 463 PRO A CB  1 
ATOM 3359 C CG  . PRO A 1 463 ? 106.673 153.230 116.941 1.00 55.74  ? 463 PRO A CG  1 
ATOM 3360 C CD  . PRO A 1 463 ? 107.933 153.252 117.725 1.00 56.90  ? 463 PRO A CD  1 
ATOM 3361 N N   . SER A 1 464 ? 108.194 149.536 117.635 1.00 50.37  ? 464 SER A N   1 
ATOM 3362 C CA  . SER A 1 464 ? 108.631 148.156 117.484 1.00 45.54  ? 464 SER A CA  1 
ATOM 3363 C C   . SER A 1 464 ? 109.223 147.592 118.762 1.00 46.11  ? 464 SER A C   1 
ATOM 3364 O O   . SER A 1 464 ? 109.316 146.369 118.897 1.00 50.47  ? 464 SER A O   1 
ATOM 3365 C CB  . SER A 1 464 ? 109.656 148.037 116.359 1.00 54.23  ? 464 SER A CB  1 
ATOM 3366 O OG  . SER A 1 464 ? 110.133 146.709 116.260 1.00 59.25  ? 464 SER A OG  1 
ATOM 3367 N N   . ARG A 1 465 ? 109.628 148.445 119.697 1.00 43.18  ? 465 ARG A N   1 
ATOM 3368 C CA  . ARG A 1 465 ? 110.008 147.960 121.013 1.00 44.13  ? 465 ARG A CA  1 
ATOM 3369 C C   . ARG A 1 465 ? 108.802 147.736 121.911 1.00 47.63  ? 465 ARG A C   1 
ATOM 3370 O O   . ARG A 1 465 ? 108.971 147.260 123.039 1.00 52.98  ? 465 ARG A O   1 
ATOM 3371 C CB  . ARG A 1 465 ? 110.988 148.931 121.675 1.00 54.53  ? 465 ARG A CB  1 
ATOM 3372 C CG  . ARG A 1 465 ? 112.221 149.227 120.832 1.00 57.08  ? 465 ARG A CG  1 
ATOM 3373 C CD  . ARG A 1 465 ? 113.411 148.373 121.237 1.00 52.82  ? 465 ARG A CD  1 
ATOM 3374 N NE  . ARG A 1 465 ? 114.196 148.988 122.300 1.00 54.82  ? 465 ARG A NE  1 
ATOM 3375 C CZ  . ARG A 1 465 ? 114.272 148.525 123.540 1.00 56.48  ? 465 ARG A CZ  1 
ATOM 3376 N NH1 . ARG A 1 465 ? 113.608 147.445 123.916 1.00 57.58  ? 465 ARG A NH1 1 
ATOM 3377 N NH2 . ARG A 1 465 ? 115.035 149.161 124.424 1.00 55.40  ? 465 ARG A NH2 1 
ATOM 3378 N N   . LEU A 1 466 ? 107.595 148.071 121.443 1.00 51.46  ? 466 LEU A N   1 
ATOM 3379 C CA  . LEU A 1 466 ? 106.392 147.761 122.202 1.00 53.72  ? 466 LEU A CA  1 
ATOM 3380 C C   . LEU A 1 466 ? 106.068 146.276 122.141 1.00 54.48  ? 466 LEU A C   1 
ATOM 3381 O O   . LEU A 1 466 ? 105.439 145.748 123.062 1.00 54.99  ? 466 LEU A O   1 
ATOM 3382 C CB  . LEU A 1 466 ? 105.193 148.557 121.684 1.00 44.83  ? 466 LEU A CB  1 
ATOM 3383 C CG  . LEU A 1 466 ? 105.104 150.067 121.937 1.00 46.38  ? 466 LEU A CG  1 
ATOM 3384 C CD1 . LEU A 1 466 ? 103.700 150.583 121.632 1.00 52.43  ? 466 LEU A CD1 1 
ATOM 3385 C CD2 . LEU A 1 466 ? 105.592 150.501 123.310 1.00 47.07  ? 466 LEU A CD2 1 
ATOM 3386 N N   . LEU A 1 467 ? 106.481 145.592 121.077 1.00 40.17  ? 467 LEU A N   1 
ATOM 3387 C CA  . LEU A 1 467 ? 106.296 144.147 120.962 1.00 33.04  ? 467 LEU A CA  1 
ATOM 3388 C C   . LEU A 1 467 ? 107.501 143.384 121.513 1.00 38.65  ? 467 LEU A C   1 
ATOM 3389 O O   . LEU A 1 467 ? 107.995 142.409 120.956 1.00 35.77  ? 467 LEU A O   1 
ATOM 3390 C CB  . LEU A 1 467 ? 105.990 143.796 119.508 1.00 32.80  ? 467 LEU A CB  1 
ATOM 3391 C CG  . LEU A 1 467 ? 106.787 144.299 118.296 1.00 34.44  ? 467 LEU A CG  1 
ATOM 3392 C CD1 . LEU A 1 467 ? 107.897 143.352 117.858 1.00 43.81  ? 467 LEU A CD1 1 
ATOM 3393 C CD2 . LEU A 1 467 ? 105.839 144.575 117.157 1.00 35.27  ? 467 LEU A CD2 1 
ATOM 3394 N N   . SER A 1 468 ? 107.928 143.804 122.700 1.00 53.22  ? 468 SER A N   1 
ATOM 3395 C CA  . SER A 1 468 ? 108.981 143.132 123.438 1.00 54.88  ? 468 SER A CA  1 
ATOM 3396 C C   . SER A 1 468 ? 108.452 142.380 124.645 1.00 62.70  ? 468 SER A C   1 
ATOM 3397 O O   . SER A 1 468 ? 109.205 141.616 125.257 1.00 60.73  ? 468 SER A O   1 
ATOM 3398 C CB  . SER A 1 468 ? 110.044 144.143 123.893 1.00 55.29  ? 468 SER A CB  1 
ATOM 3399 O OG  . SER A 1 468 ? 111.234 143.486 124.290 1.00 61.67  ? 468 SER A OG  1 
ATOM 3400 N N   . LEU A 1 469 ? 107.187 142.579 125.002 1.00 63.45  ? 469 LEU A N   1 
ATOM 3401 C CA  . LEU A 1 469 ? 106.536 141.855 126.084 1.00 59.72  ? 469 LEU A CA  1 
ATOM 3402 C C   . LEU A 1 469 ? 105.801 140.612 125.601 1.00 53.98  ? 469 LEU A C   1 
ATOM 3403 O O   . LEU A 1 469 ? 105.277 139.859 126.427 1.00 55.46  ? 469 LEU A O   1 
ATOM 3404 C CB  . LEU A 1 469 ? 105.562 142.787 126.821 1.00 56.90  ? 469 LEU A CB  1 
ATOM 3405 C CG  . LEU A 1 469 ? 104.104 142.929 126.361 1.00 57.91  ? 469 LEU A CG  1 
ATOM 3406 C CD1 . LEU A 1 469 ? 103.325 143.774 127.354 1.00 60.82  ? 469 LEU A CD1 1 
ATOM 3407 C CD2 . LEU A 1 469 ? 103.976 143.519 124.967 1.00 52.51  ? 469 LEU A CD2 1 
ATOM 3408 N N   . MET A 1 470 ? 105.767 140.371 124.290 1.00 53.43  ? 470 MET A N   1 
ATOM 3409 C CA  . MET A 1 470 ? 104.979 139.297 123.708 1.00 51.90  ? 470 MET A CA  1 
ATOM 3410 C C   . MET A 1 470 ? 105.797 138.252 122.962 1.00 48.43  ? 470 MET A C   1 
ATOM 3411 O O   . MET A 1 470 ? 105.234 137.223 122.570 1.00 41.43  ? 470 MET A O   1 
ATOM 3412 C CB  . MET A 1 470 ? 103.930 139.877 122.747 1.00 43.70  ? 470 MET A CB  1 
ATOM 3413 C CG  . MET A 1 470 ? 104.481 140.223 121.376 1.00 46.48  ? 470 MET A CG  1 
ATOM 3414 S SD  . MET A 1 470 ? 103.232 140.234 120.082 1.00 42.33  ? 470 MET A SD  1 
ATOM 3415 C CE  . MET A 1 470 ? 102.263 141.656 120.571 1.00 36.15  ? 470 MET A CE  1 
ATOM 3416 N N   . ASP A 1 471 ? 107.092 138.479 122.753 1.00 58.72  ? 471 ASP A N   1 
ATOM 3417 C CA  . ASP A 1 471 ? 107.891 137.587 121.927 1.00 60.14  ? 471 ASP A CA  1 
ATOM 3418 C C   . ASP A 1 471 ? 108.135 136.254 122.636 1.00 59.95  ? 471 ASP A C   1 
ATOM 3419 O O   . ASP A 1 471 ? 108.205 136.200 123.866 1.00 59.46  ? 471 ASP A O   1 
ATOM 3420 C CB  . ASP A 1 471 ? 109.220 138.247 121.575 1.00 59.70  ? 471 ASP A CB  1 
ATOM 3421 C CG  . ASP A 1 471 ? 109.252 138.757 120.151 1.00 58.97  ? 471 ASP A CG  1 
ATOM 3422 O OD1 . ASP A 1 471 ? 108.659 138.104 119.269 1.00 58.95  ? 471 ASP A OD1 1 
ATOM 3423 O OD2 . ASP A 1 471 ? 109.875 139.810 119.911 1.00 66.30  ? 471 ASP A OD2 1 
ATOM 3424 N N   . PRO A 1 472 ? 108.258 135.151 121.875 1.00 58.32  ? 472 PRO A N   1 
ATOM 3425 C CA  . PRO A 1 472 ? 108.389 133.827 122.502 1.00 67.48  ? 472 PRO A CA  1 
ATOM 3426 C C   . PRO A 1 472 ? 109.691 133.586 123.248 1.00 62.90  ? 472 PRO A C   1 
ATOM 3427 O O   . PRO A 1 472 ? 109.678 133.120 124.389 1.00 57.58  ? 472 PRO A O   1 
ATOM 3428 C CB  . PRO A 1 472 ? 108.264 132.869 121.312 1.00 66.47  ? 472 PRO A CB  1 
ATOM 3429 C CG  . PRO A 1 472 ? 108.637 133.678 120.126 1.00 60.06  ? 472 PRO A CG  1 
ATOM 3430 C CD  . PRO A 1 472 ? 108.115 135.045 120.413 1.00 52.74  ? 472 PRO A CD  1 
ATOM 3431 N N   . LEU A 1 473 ? 110.809 133.905 122.604 1.00 64.75  ? 473 LEU A N   1 
ATOM 3432 C CA  . LEU A 1 473 ? 112.115 133.633 123.200 1.00 66.39  ? 473 LEU A CA  1 
ATOM 3433 C C   . LEU A 1 473 ? 112.543 134.618 124.273 1.00 68.04  ? 473 LEU A C   1 
ATOM 3434 O O   . LEU A 1 473 ? 113.117 134.213 125.279 1.00 69.54  ? 473 LEU A O   1 
ATOM 3435 C CB  . LEU A 1 473 ? 113.184 133.605 122.100 1.00 66.49  ? 473 LEU A CB  1 
ATOM 3436 C CG  . LEU A 1 473 ? 113.573 134.958 121.494 1.00 66.25  ? 473 LEU A CG  1 
ATOM 3437 C CD1 . LEU A 1 473 ? 115.080 135.103 121.350 1.00 66.09  ? 473 LEU A CD1 1 
ATOM 3438 C CD2 . LEU A 1 473 ? 112.863 135.210 120.174 1.00 66.14  ? 473 LEU A CD2 1 
ATOM 3439 N N   . LEU A 1 474 ? 112.275 135.903 124.079 1.00 63.86  ? 474 LEU A N   1 
ATOM 3440 C CA  . LEU A 1 474 ? 112.777 136.888 125.037 1.00 67.84  ? 474 LEU A CA  1 
ATOM 3441 C C   . LEU A 1 474 ? 111.730 137.868 125.543 1.00 66.65  ? 474 LEU A C   1 
ATOM 3442 O O   . LEU A 1 474 ? 110.905 138.361 124.774 1.00 66.53  ? 474 LEU A O   1 
ATOM 3443 C CB  . LEU A 1 474 ? 113.975 137.646 124.431 1.00 65.45  ? 474 LEU A CB  1 
ATOM 3444 C CG  . LEU A 1 474 ? 113.837 138.765 123.389 1.00 64.10  ? 474 LEU A CG  1 
ATOM 3445 C CD1 . LEU A 1 474 ? 112.846 138.460 122.275 1.00 64.10  ? 474 LEU A CD1 1 
ATOM 3446 C CD2 . LEU A 1 474 ? 113.578 140.129 124.013 1.00 65.18  ? 474 LEU A CD2 1 
ATOM 3447 N N   . PRO A 1 475 ? 111.748 138.136 126.853 1.00 30.00  ? 475 PRO A N   1 
ATOM 3448 C CA  . PRO A 1 475 ? 110.832 139.138 127.397 1.00 30.00  ? 475 PRO A CA  1 
ATOM 3449 C C   . PRO A 1 475 ? 111.485 140.505 127.391 1.00 30.00  ? 475 PRO A C   1 
ATOM 3450 O O   . PRO A 1 475 ? 112.676 140.618 127.097 1.00 30.00  ? 475 PRO A O   1 
ATOM 3451 C CB  . PRO A 1 475 ? 110.640 138.673 128.834 1.00 30.00  ? 475 PRO A CB  1 
ATOM 3452 C CG  . PRO A 1 475 ? 111.936 138.022 129.178 1.00 30.00  ? 475 PRO A CG  1 
ATOM 3453 C CD  . PRO A 1 475 ? 112.410 137.357 127.914 1.00 30.00  ? 475 PRO A CD  1 
ATOM 3454 N N   . LEU A 1 476 ? 110.721 141.535 127.723 1.00 61.35  ? 476 LEU A N   1 
ATOM 3455 C CA  . LEU A 1 476 ? 111.257 142.888 127.751 1.00 60.90  ? 476 LEU A CA  1 
ATOM 3456 C C   . LEU A 1 476 ? 112.502 143.000 128.616 1.00 60.61  ? 476 LEU A C   1 
ATOM 3457 O O   . LEU A 1 476 ? 113.292 143.928 128.444 1.00 62.83  ? 476 LEU A O   1 
ATOM 3458 C CB  . LEU A 1 476 ? 110.196 143.854 128.275 1.00 61.44  ? 476 LEU A CB  1 
ATOM 3459 C CG  . LEU A 1 476 ? 109.436 144.690 127.247 1.00 68.50  ? 476 LEU A CG  1 
ATOM 3460 C CD1 . LEU A 1 476 ? 108.051 145.036 127.765 1.00 58.91  ? 476 LEU A CD1 1 
ATOM 3461 C CD2 . LEU A 1 476 ? 110.213 145.954 126.913 1.00 62.50  ? 476 LEU A CD2 1 
ATOM 3462 N N   . SER A 1 477 ? 112.695 142.066 129.542 1.00 67.34  ? 477 SER A N   1 
ATOM 3463 C CA  . SER A 1 477 ? 113.816 142.186 130.462 1.00 64.01  ? 477 SER A CA  1 
ATOM 3464 C C   . SER A 1 477 ? 115.119 141.641 129.902 1.00 67.57  ? 477 SER A C   1 
ATOM 3465 O O   . SER A 1 477 ? 116.141 141.742 130.586 1.00 70.10  ? 477 SER A O   1 
ATOM 3466 C CB  . SER A 1 477 ? 113.502 141.477 131.778 1.00 66.26  ? 477 SER A CB  1 
ATOM 3467 O OG  . SER A 1 477 ? 112.603 142.239 132.564 1.00 75.38  ? 477 SER A OG  1 
ATOM 3468 N N   . VAL A 1 478 ? 115.115 141.046 128.708 1.00 63.10  ? 478 VAL A N   1 
ATOM 3469 C CA  . VAL A 1 478 ? 116.368 140.601 128.106 1.00 62.55  ? 478 VAL A CA  1 
ATOM 3470 C C   . VAL A 1 478 ? 117.233 141.799 127.727 1.00 59.22  ? 478 VAL A C   1 
ATOM 3471 O O   . VAL A 1 478 ? 118.418 141.866 128.074 1.00 62.80  ? 478 VAL A O   1 
ATOM 3472 C CB  . VAL A 1 478 ? 116.085 139.693 126.896 1.00 62.02  ? 478 VAL A CB  1 
ATOM 3473 C CG1 . VAL A 1 478 ? 117.330 139.523 126.044 1.00 62.59  ? 478 VAL A CG1 1 
ATOM 3474 C CG2 . VAL A 1 478 ? 115.579 138.345 127.367 1.00 57.86  ? 478 VAL A CG2 1 
ATOM 3475 N N   . LEU A 1 479 ? 116.648 142.777 127.034 1.00 62.38  ? 479 LEU A N   1 
ATOM 3476 C CA  . LEU A 1 479 ? 117.420 143.940 126.606 1.00 63.66  ? 479 LEU A CA  1 
ATOM 3477 C C   . LEU A 1 479 ? 117.496 145.013 127.678 1.00 65.02  ? 479 LEU A C   1 
ATOM 3478 O O   . LEU A 1 479 ? 118.345 145.906 127.594 1.00 67.32  ? 479 LEU A O   1 
ATOM 3479 C CB  . LEU A 1 479 ? 116.833 144.539 125.331 1.00 63.74  ? 479 LEU A CB  1 
ATOM 3480 C CG  . LEU A 1 479 ? 117.254 143.932 123.992 1.00 64.64  ? 479 LEU A CG  1 
ATOM 3481 C CD1 . LEU A 1 479 ? 118.735 144.181 123.726 1.00 62.98  ? 479 LEU A CD1 1 
ATOM 3482 C CD2 . LEU A 1 479 ? 116.896 142.460 123.804 1.00 60.65  ? 479 LEU A CD2 1 
ATOM 3483 N N   . SER A 1 480 ? 116.613 144.959 128.673 1.00 76.37  ? 480 SER A N   1 
ATOM 3484 C CA  . SER A 1 480 ? 116.700 145.896 129.785 1.00 72.79  ? 480 SER A CA  1 
ATOM 3485 C C   . SER A 1 480 ? 117.928 145.616 130.639 1.00 75.43  ? 480 SER A C   1 
ATOM 3486 O O   . SER A 1 480 ? 118.571 146.547 131.138 1.00 72.49  ? 480 SER A O   1 
ATOM 3487 C CB  . SER A 1 480 ? 115.428 145.822 130.627 1.00 74.67  ? 480 SER A CB  1 
ATOM 3488 O OG  . SER A 1 480 ? 114.437 146.708 130.136 1.00 77.38  ? 480 SER A OG  1 
ATOM 3489 N N   . LYS A 1 481 ? 118.266 144.343 130.818 1.00 67.17  ? 481 LYS A N   1 
ATOM 3490 C CA  . LYS A 1 481 ? 119.416 143.944 131.614 1.00 57.45  ? 481 LYS A CA  1 
ATOM 3491 C C   . LYS A 1 481 ? 120.647 143.637 130.773 1.00 62.58  ? 481 LYS A C   1 
ATOM 3492 O O   . LYS A 1 481 ? 121.702 143.334 131.338 1.00 71.44  ? 481 LYS A O   1 
ATOM 3493 C CB  . LYS A 1 481 ? 119.054 142.732 132.474 1.00 60.19  ? 481 LYS A CB  1 
ATOM 3494 C CG  . LYS A 1 481 ? 117.732 142.881 133.205 1.00 68.25  ? 481 LYS A CG  1 
ATOM 3495 C CD  . LYS A 1 481 ? 117.760 142.207 134.563 1.00 64.71  ? 481 LYS A CD  1 
ATOM 3496 C CE  . LYS A 1 481 ? 116.569 142.634 135.399 1.00 62.62  ? 481 LYS A CE  1 
ATOM 3497 N NZ  . LYS A 1 481 ? 115.287 142.352 134.698 1.00 65.46  ? 481 LYS A NZ  1 
ATOM 3498 N N   . CYS A 1 482 ? 120.542 143.701 129.444 1.00 62.20  ? 482 CYS A N   1 
ATOM 3499 C CA  . CYS A 1 482 ? 121.726 143.561 128.602 1.00 66.00  ? 482 CYS A CA  1 
ATOM 3500 C C   . CYS A 1 482 ? 122.581 144.823 128.631 1.00 62.68  ? 482 CYS A C   1 
ATOM 3501 O O   . CYS A 1 482 ? 123.813 144.741 128.661 1.00 60.64  ? 482 CYS A O   1 
ATOM 3502 C CB  . CYS A 1 482 ? 121.318 143.219 127.167 1.00 57.94  ? 482 CYS A CB  1 
ATOM 3503 S SG  . CYS A 1 482 ? 122.522 143.672 125.897 1.00 39.93  ? 482 CYS A SG  1 
ATOM 3504 N N   . VAL A 1 483 ? 121.948 145.998 128.635 1.00 49.29  ? 483 VAL A N   1 
ATOM 3505 C CA  . VAL A 1 483 ? 122.706 147.242 128.686 1.00 40.43  ? 483 VAL A CA  1 
ATOM 3506 C C   . VAL A 1 483 ? 123.134 147.594 130.106 1.00 48.03  ? 483 VAL A C   1 
ATOM 3507 O O   . VAL A 1 483 ? 124.017 148.441 130.287 1.00 58.60  ? 483 VAL A O   1 
ATOM 3508 C CB  . VAL A 1 483 ? 121.898 148.389 128.054 1.00 48.02  ? 483 VAL A CB  1 
ATOM 3509 C CG1 . VAL A 1 483 ? 120.966 149.039 129.072 1.00 53.80  ? 483 VAL A CG1 1 
ATOM 3510 C CG2 . VAL A 1 483 ? 122.831 149.418 127.437 1.00 56.30  ? 483 VAL A CG2 1 
ATOM 3511 N N   . SER A 1 484 ? 122.540 146.971 131.126 1.00 57.05  ? 484 SER A N   1 
ATOM 3512 C CA  . SER A 1 484 ? 123.065 147.135 132.477 1.00 61.60  ? 484 SER A CA  1 
ATOM 3513 C C   . SER A 1 484 ? 124.385 146.393 132.634 1.00 57.24  ? 484 SER A C   1 
ATOM 3514 O O   . SER A 1 484 ? 125.279 146.843 133.360 1.00 54.96  ? 484 SER A O   1 
ATOM 3515 C CB  . SER A 1 484 ? 122.044 146.648 133.505 1.00 61.34  ? 484 SER A CB  1 
ATOM 3516 O OG  . SER A 1 484 ? 122.643 146.475 134.777 1.00 65.85  ? 484 SER A OG  1 
ATOM 3517 N N   . ALA A 1 485 ? 124.520 145.254 131.955 1.00 51.12  ? 485 ALA A N   1 
ATOM 3518 C CA  . ALA A 1 485 ? 125.765 144.500 131.997 1.00 55.71  ? 485 ALA A CA  1 
ATOM 3519 C C   . ALA A 1 485 ? 126.852 145.174 131.170 1.00 59.73  ? 485 ALA A C   1 
ATOM 3520 O O   . ALA A 1 485 ? 128.009 145.244 131.598 1.00 61.28  ? 485 ALA A O   1 
ATOM 3521 C CB  . ALA A 1 485 ? 125.522 143.075 131.504 1.00 51.01  ? 485 ALA A CB  1 
ATOM 3522 N N   . TYR A 1 486 ? 126.497 145.666 129.980 1.00 54.09  ? 486 TYR A N   1 
ATOM 3523 C CA  . TYR A 1 486 ? 127.476 146.290 129.093 1.00 50.40  ? 486 TYR A CA  1 
ATOM 3524 C C   . TYR A 1 486 ? 128.019 147.588 129.681 1.00 53.66  ? 486 TYR A C   1 
ATOM 3525 O O   . TYR A 1 486 ? 129.234 147.809 129.690 1.00 61.73  ? 486 TYR A O   1 
ATOM 3526 C CB  . TYR A 1 486 ? 126.840 146.541 127.726 1.00 54.78  ? 486 TYR A CB  1 
ATOM 3527 C CG  . TYR A 1 486 ? 127.783 146.554 126.542 1.00 50.10  ? 486 TYR A CG  1 
ATOM 3528 C CD1 . TYR A 1 486 ? 129.152 146.700 126.708 1.00 56.10  ? 486 TYR A CD1 1 
ATOM 3529 C CD2 . TYR A 1 486 ? 127.293 146.445 125.251 1.00 55.49  ? 486 TYR A CD2 1 
ATOM 3530 C CE1 . TYR A 1 486 ? 130.007 146.724 125.623 1.00 56.05  ? 486 TYR A CE1 1 
ATOM 3531 C CE2 . TYR A 1 486 ? 128.138 146.468 124.160 1.00 57.95  ? 486 TYR A CE2 1 
ATOM 3532 C CZ  . TYR A 1 486 ? 129.495 146.608 124.352 1.00 55.46  ? 486 TYR A CZ  1 
ATOM 3533 O OH  . TYR A 1 486 ? 130.344 146.633 123.269 1.00 50.00  ? 486 TYR A OH  1 
ATOM 3534 N N   . ALA A 1 487 ? 127.143 148.455 130.183 1.00 55.89  ? 487 ALA A N   1 
ATOM 3535 C CA  . ALA A 1 487 ? 127.588 149.739 130.706 1.00 58.57  ? 487 ALA A CA  1 
ATOM 3536 C C   . ALA A 1 487 ? 128.140 149.651 132.122 1.00 66.41  ? 487 ALA A C   1 
ATOM 3537 O O   . ALA A 1 487 ? 128.681 150.646 132.616 1.00 69.87  ? 487 ALA A O   1 
ATOM 3538 C CB  . ALA A 1 487 ? 126.441 150.750 130.668 1.00 62.49  ? 487 ALA A CB  1 
ATOM 3539 N N   . GLY A 1 488 ? 128.031 148.496 132.775 1.00 74.86  ? 488 GLY A N   1 
ATOM 3540 C CA  . GLY A 1 488 ? 128.526 148.339 134.129 1.00 74.36  ? 488 GLY A CA  1 
ATOM 3541 C C   . GLY A 1 488 ? 127.796 149.184 135.153 1.00 75.99  ? 488 GLY A C   1 
ATOM 3542 O O   . GLY A 1 488 ? 128.427 149.860 135.971 1.00 78.91  ? 488 GLY A O   1 
ATOM 3543 N N   . ALA A 1 489 ? 126.466 149.167 135.100 1.00 87.84  ? 489 ALA A N   1 
ATOM 3544 C CA  . ALA A 1 489 ? 125.659 149.930 136.041 1.00 90.34  ? 489 ALA A CA  1 
ATOM 3545 C C   . ALA A 1 489 ? 125.792 149.373 137.456 1.00 89.48  ? 489 ALA A C   1 
ATOM 3546 O O   . ALA A 1 489 ? 125.960 148.169 137.664 1.00 90.39  ? 489 ALA A O   1 
ATOM 3547 C CB  . ALA A 1 489 ? 124.192 149.918 135.613 1.00 90.55  ? 489 ALA A CB  1 
ATOM 3548 N N   . LYS A 1 490 ? 125.718 150.272 138.434 1.00 105.86 ? 490 LYS A N   1 
ATOM 3549 C CA  . LYS A 1 490 ? 125.841 149.904 139.838 1.00 105.90 ? 490 LYS A CA  1 
ATOM 3550 C C   . LYS A 1 490 ? 124.458 149.705 140.445 1.00 107.17 ? 490 LYS A C   1 
ATOM 3551 O O   . LYS A 1 490 ? 123.579 150.562 140.302 1.00 105.10 ? 490 LYS A O   1 
ATOM 3552 C CB  . LYS A 1 490 ? 126.608 150.976 140.613 1.00 104.80 ? 490 LYS A CB  1 
ATOM 3553 C CG  . LYS A 1 490 ? 127.783 151.573 139.856 1.00 103.55 ? 490 LYS A CG  1 
ATOM 3554 C CD  . LYS A 1 490 ? 127.889 153.070 140.095 1.00 104.57 ? 490 LYS A CD  1 
ATOM 3555 C CE  . LYS A 1 490 ? 128.822 153.725 139.090 1.00 104.82 ? 490 LYS A CE  1 
ATOM 3556 N NZ  . LYS A 1 490 ? 128.332 153.570 137.693 1.00 105.94 ? 490 LYS A NZ  1 
ATOM 3557 N N   . THR A 1 491 ? 124.269 148.575 141.120 1.00 115.64 ? 491 THR A N   1 
ATOM 3558 C CA  . THR A 1 491 ? 122.995 148.269 141.759 1.00 112.88 ? 491 THR A CA  1 
ATOM 3559 C C   . THR A 1 491 ? 122.925 148.878 143.155 1.00 111.06 ? 491 THR A C   1 
ATOM 3560 O O   . THR A 1 491 ? 121.841 149.148 143.672 1.00 108.40 ? 491 THR A O   1 
ATOM 3561 C CB  . THR A 1 491 ? 122.762 146.751 141.859 1.00 110.65 ? 491 THR A CB  1 
ATOM 3562 O OG1 . THR A 1 491 ? 123.823 146.149 142.612 1.00 110.58 ? 491 THR A OG1 1 
ATOM 3563 C CG2 . THR A 1 491 ? 122.713 146.127 140.473 1.00 110.66 ? 491 THR A CG2 1 
ATOM 3564 N N   . ALA A 1 638 ? 95.264  161.512 128.699 1.00 86.34  ? 638 ALA A N   1 
ATOM 3565 C CA  . ALA A 1 638 ? 94.909  160.409 129.583 1.00 87.49  ? 638 ALA A CA  1 
ATOM 3566 C C   . ALA A 1 638 ? 95.594  159.121 129.144 1.00 86.39  ? 638 ALA A C   1 
ATOM 3567 O O   . ALA A 1 638 ? 95.909  158.945 127.967 1.00 86.49  ? 638 ALA A O   1 
ATOM 3568 C CB  . ALA A 1 638 ? 93.400  160.221 129.618 1.00 84.81  ? 638 ALA A CB  1 
ATOM 3569 N N   . ALA A 1 639 ? 95.834  158.226 130.106 1.00 82.10  ? 639 ALA A N   1 
ATOM 3570 C CA  . ALA A 1 639 ? 96.442  156.939 129.786 1.00 80.32  ? 639 ALA A CA  1 
ATOM 3571 C C   . ALA A 1 639 ? 95.490  156.061 128.984 1.00 78.30  ? 639 ALA A C   1 
ATOM 3572 O O   . ALA A 1 639 ? 95.914  155.361 128.057 1.00 78.60  ? 639 ALA A O   1 
ATOM 3573 C CB  . ALA A 1 639 ? 96.877  156.229 131.068 1.00 79.97  ? 639 ALA A CB  1 
ATOM 3574 N N   . PHE A 1 640 ? 94.202  156.087 129.322 1.00 76.68  ? 640 PHE A N   1 
ATOM 3575 C CA  . PHE A 1 640 ? 93.206  155.271 128.645 1.00 76.23  ? 640 PHE A CA  1 
ATOM 3576 C C   . PHE A 1 640 ? 91.842  155.908 128.845 1.00 77.32  ? 640 PHE A C   1 
ATOM 3577 O O   . PHE A 1 640 ? 91.618  156.567 129.868 1.00 78.96  ? 640 PHE A O   1 
ATOM 3578 C CB  . PHE A 1 640 ? 93.212  153.834 129.184 1.00 75.24  ? 640 PHE A CB  1 
ATOM 3579 C CG  . PHE A 1 640 ? 94.023  152.884 128.357 1.00 69.38  ? 640 PHE A CG  1 
ATOM 3580 C CD1 . PHE A 1 640 ? 93.924  152.894 126.976 1.00 65.23  ? 640 PHE A CD1 1 
ATOM 3581 C CD2 . PHE A 1 640 ? 94.890  151.987 128.957 1.00 70.42  ? 640 PHE A CD2 1 
ATOM 3582 C CE1 . PHE A 1 640 ? 94.669  152.024 126.209 1.00 69.04  ? 640 PHE A CE1 1 
ATOM 3583 C CE2 . PHE A 1 640 ? 95.638  151.114 128.196 1.00 73.17  ? 640 PHE A CE2 1 
ATOM 3584 C CZ  . PHE A 1 640 ? 95.527  151.133 126.818 1.00 71.80  ? 640 PHE A CZ  1 
ATOM 3585 N N   . PRO A 1 641 ? 90.922  155.751 127.895 1.00 85.50  ? 641 PRO A N   1 
ATOM 3586 C CA  . PRO A 1 641 ? 89.564  156.271 128.087 1.00 85.59  ? 641 PRO A CA  1 
ATOM 3587 C C   . PRO A 1 641 ? 88.826  155.522 129.188 1.00 84.49  ? 641 PRO A C   1 
ATOM 3588 O O   . PRO A 1 641 ? 89.130  154.372 129.514 1.00 83.98  ? 641 PRO A O   1 
ATOM 3589 C CB  . PRO A 1 641 ? 88.897  156.052 126.724 1.00 85.70  ? 641 PRO A CB  1 
ATOM 3590 C CG  . PRO A 1 641 ? 89.717  154.999 126.057 1.00 85.88  ? 641 PRO A CG  1 
ATOM 3591 C CD  . PRO A 1 641 ? 91.116  155.207 126.540 1.00 84.82  ? 641 PRO A CD  1 
ATOM 3592 N N   . GLU A 1 642 ? 87.848  156.212 129.773 1.00 92.19  ? 642 GLU A N   1 
ATOM 3593 C CA  . GLU A 1 642 ? 87.070  155.644 130.866 1.00 90.02  ? 642 GLU A CA  1 
ATOM 3594 C C   . GLU A 1 642 ? 86.194  154.500 130.373 1.00 90.94  ? 642 GLU A C   1 
ATOM 3595 O O   . GLU A 1 642 ? 85.639  154.547 129.271 1.00 90.30  ? 642 GLU A O   1 
ATOM 3596 C CB  . GLU A 1 642 ? 86.202  156.721 131.517 1.00 91.93  ? 642 GLU A CB  1 
ATOM 3597 C CG  . GLU A 1 642 ? 86.980  157.758 132.309 1.00 93.33  ? 642 GLU A CG  1 
ATOM 3598 C CD  . GLU A 1 642 ? 87.249  159.019 131.511 1.00 92.13  ? 642 GLU A CD  1 
ATOM 3599 O OE1 . GLU A 1 642 ? 87.298  158.939 130.265 1.00 92.60  ? 642 GLU A OE1 1 
ATOM 3600 O OE2 . GLU A 1 642 ? 87.409  160.092 132.130 1.00 89.68  ? 642 GLU A OE2 1 
ATOM 3601 N N   . GLY A 1 643 ? 86.074  153.464 131.200 1.00 80.47  ? 643 GLY A N   1 
ATOM 3602 C CA  . GLY A 1 643 ? 85.287  152.299 130.871 1.00 79.00  ? 643 GLY A CA  1 
ATOM 3603 C C   . GLY A 1 643 ? 86.042  151.193 130.169 1.00 79.51  ? 643 GLY A C   1 
ATOM 3604 O O   . GLY A 1 643 ? 85.496  150.093 130.017 1.00 79.65  ? 643 GLY A O   1 
ATOM 3605 N N   . PHE A 1 644 ? 87.275  151.442 129.739 1.00 71.71  ? 644 PHE A N   1 
ATOM 3606 C CA  . PHE A 1 644 ? 88.109  150.433 129.099 1.00 69.85  ? 644 PHE A CA  1 
ATOM 3607 C C   . PHE A 1 644 ? 89.146  149.959 130.105 1.00 68.01  ? 644 PHE A C   1 
ATOM 3608 O O   . PHE A 1 644 ? 89.960  150.756 130.582 1.00 63.53  ? 644 PHE A O   1 
ATOM 3609 C CB  . PHE A 1 644 ? 88.784  150.988 127.845 1.00 70.72  ? 644 PHE A CB  1 
ATOM 3610 C CG  . PHE A 1 644 ? 89.845  150.087 127.278 1.00 69.94  ? 644 PHE A CG  1 
ATOM 3611 C CD1 . PHE A 1 644 ? 89.497  148.931 126.600 1.00 71.86  ? 644 PHE A CD1 1 
ATOM 3612 C CD2 . PHE A 1 644 ? 91.187  150.401 127.413 1.00 68.78  ? 644 PHE A CD2 1 
ATOM 3613 C CE1 . PHE A 1 644 ? 90.467  148.100 126.075 1.00 71.49  ? 644 PHE A CE1 1 
ATOM 3614 C CE2 . PHE A 1 644 ? 92.162  149.575 126.889 1.00 69.08  ? 644 PHE A CE2 1 
ATOM 3615 C CZ  . PHE A 1 644 ? 91.801  148.423 126.219 1.00 65.05  ? 644 PHE A CZ  1 
ATOM 3616 N N   . HIS A 1 645 ? 89.118  148.670 130.419 1.00 82.45  ? 645 HIS A N   1 
ATOM 3617 C CA  . HIS A 1 645 ? 90.040  148.137 131.410 1.00 79.91  ? 645 HIS A CA  1 
ATOM 3618 C C   . HIS A 1 645 ? 90.323  146.663 131.152 1.00 77.80  ? 645 HIS A C   1 
ATOM 3619 O O   . HIS A 1 645 ? 89.585  145.792 131.629 1.00 77.95  ? 645 HIS A O   1 
ATOM 3620 C CB  . HIS A 1 645 ? 89.485  148.332 132.825 1.00 77.92  ? 645 HIS A CB  1 
ATOM 3621 C CG  . HIS A 1 645 ? 88.002  148.152 132.930 1.00 77.99  ? 645 HIS A CG  1 
ATOM 3622 N ND1 . HIS A 1 645 ? 87.106  149.159 132.640 1.00 77.99  ? 645 HIS A ND1 1 
ATOM 3623 C CD2 . HIS A 1 645 ? 87.258  147.083 133.301 1.00 78.13  ? 645 HIS A CD2 1 
ATOM 3624 C CE1 . HIS A 1 645 ? 85.875  148.717 132.823 1.00 79.05  ? 645 HIS A CE1 1 
ATOM 3625 N NE2 . HIS A 1 645 ? 85.939  147.460 133.225 1.00 80.81  ? 645 HIS A NE2 1 
ATOM 3626 N N   . PRO A 1 646 ? 91.383  146.341 130.406 1.00 78.84  ? 646 PRO A N   1 
ATOM 3627 C CA  . PRO A 1 646 ? 91.806  144.938 130.300 1.00 82.46  ? 646 PRO A CA  1 
ATOM 3628 C C   . PRO A 1 646 ? 92.544  144.492 131.553 1.00 75.14  ? 646 PRO A C   1 
ATOM 3629 O O   . PRO A 1 646 ? 92.648  145.258 132.518 1.00 75.36  ? 646 PRO A O   1 
ATOM 3630 C CB  . PRO A 1 646 ? 92.714  144.938 129.065 1.00 77.95  ? 646 PRO A CB  1 
ATOM 3631 C CG  . PRO A 1 646 ? 93.254  146.323 128.998 1.00 75.46  ? 646 PRO A CG  1 
ATOM 3632 C CD  . PRO A 1 646 ? 92.217  147.240 129.590 1.00 71.86  ? 646 PRO A CD  1 
ATOM 3633 N N   . ARG A 1 647 ? 93.050  143.260 131.564 1.00 67.54  ? 647 ARG A N   1 
ATOM 3634 C CA  . ARG A 1 647 ? 93.799  142.779 132.717 1.00 72.47  ? 647 ARG A CA  1 
ATOM 3635 C C   . ARG A 1 647 ? 95.117  143.535 132.842 1.00 72.57  ? 647 ARG A C   1 
ATOM 3636 O O   . ARG A 1 647 ? 95.823  143.747 131.852 1.00 66.70  ? 647 ARG A O   1 
ATOM 3637 C CB  . ARG A 1 647 ? 94.048  141.276 132.604 1.00 75.87  ? 647 ARG A CB  1 
ATOM 3638 C CG  . ARG A 1 647 ? 93.956  140.538 133.933 1.00 76.81  ? 647 ARG A CG  1 
ATOM 3639 C CD  . ARG A 1 647 ? 95.321  140.435 134.592 1.00 72.39  ? 647 ARG A CD  1 
ATOM 3640 N NE  . ARG A 1 647 ? 95.323  139.532 135.737 1.00 68.69  ? 647 ARG A NE  1 
ATOM 3641 C CZ  . ARG A 1 647 ? 95.029  139.896 136.977 1.00 71.13  ? 647 ARG A CZ  1 
ATOM 3642 N NH1 . ARG A 1 647 ? 94.704  141.144 137.272 1.00 74.07  ? 647 ARG A NH1 1 
ATOM 3643 N NH2 . ARG A 1 647 ? 95.067  138.987 137.947 1.00 72.37  ? 647 ARG A NH2 1 
ATOM 3644 N N   . ARG A 1 648 ? 95.438  143.956 134.062 1.00 74.88  ? 648 ARG A N   1 
ATOM 3645 C CA  . ARG A 1 648 ? 96.610  144.772 134.329 1.00 73.38  ? 648 ARG A CA  1 
ATOM 3646 C C   . ARG A 1 648 ? 97.546  144.039 135.279 1.00 75.10  ? 648 ARG A C   1 
ATOM 3647 O O   . ARG A 1 648 ? 97.109  143.261 136.132 1.00 73.05  ? 648 ARG A O   1 
ATOM 3648 C CB  . ARG A 1 648 ? 96.216  146.129 134.924 1.00 75.21  ? 648 ARG A CB  1 
ATOM 3649 C CG  . ARG A 1 648 ? 95.127  146.853 134.151 1.00 73.63  ? 648 ARG A CG  1 
ATOM 3650 C CD  . ARG A 1 648 ? 95.515  147.049 132.696 1.00 76.55  ? 648 ARG A CD  1 
ATOM 3651 N NE  . ARG A 1 648 ? 96.316  148.252 132.502 1.00 81.63  ? 648 ARG A NE  1 
ATOM 3652 C CZ  . ARG A 1 648 ? 95.813  149.464 132.314 1.00 79.31  ? 648 ARG A CZ  1 
ATOM 3653 N NH1 . ARG A 1 648 ? 94.507  149.675 132.292 1.00 78.03  ? 648 ARG A NH1 1 
ATOM 3654 N NH2 . ARG A 1 648 ? 96.641  150.490 132.141 1.00 75.70  ? 648 ARG A NH2 1 
ATOM 3655 N N   . SER A 1 649 ? 98.843  144.293 135.119 1.00 80.84  ? 649 SER A N   1 
ATOM 3656 C CA  . SER A 1 649 ? 99.875  143.610 135.896 1.00 85.50  ? 649 SER A CA  1 
ATOM 3657 C C   . SER A 1 649 ? 99.945  144.244 137.278 1.00 85.35  ? 649 SER A C   1 
ATOM 3658 O O   . SER A 1 649 ? 100.497 145.332 137.450 1.00 86.96  ? 649 SER A O   1 
ATOM 3659 C CB  . SER A 1 649 ? 101.218 143.683 135.180 1.00 80.86  ? 649 SER A CB  1 
ATOM 3660 O OG  . SER A 1 649 ? 101.785 144.977 135.289 1.00 78.00  ? 649 SER A OG  1 
ATOM 3661 N N   . SER A 1 650 ? 99.376  143.563 138.269 1.00 86.41  ? 650 SER A N   1 
ATOM 3662 C CA  . SER A 1 650 ? 99.380  144.031 139.647 1.00 86.31  ? 650 SER A CA  1 
ATOM 3663 C C   . SER A 1 650 ? 100.395 143.296 140.511 1.00 87.28  ? 650 SER A C   1 
ATOM 3664 O O   . SER A 1 650 ? 100.340 143.403 141.741 1.00 87.70  ? 650 SER A O   1 
ATOM 3665 C CB  . SER A 1 650 ? 97.982  143.894 140.255 1.00 89.79  ? 650 SER A CB  1 
ATOM 3666 O OG  . SER A 1 650 ? 97.770  142.584 140.753 1.00 91.44  ? 650 SER A OG  1 
ATOM 3667 N N   . GLN A 1 651 ? 101.314 142.553 139.902 1.00 88.27  ? 651 GLN A N   1 
ATOM 3668 C CA  . GLN A 1 651 ? 102.301 141.765 140.642 1.00 92.62  ? 651 GLN A CA  1 
ATOM 3669 C C   . GLN A 1 651 ? 103.545 142.584 140.980 1.00 91.42  ? 651 GLN A C   1 
ATOM 3670 O O   . GLN A 1 651 ? 104.673 142.194 140.679 1.00 90.05  ? 651 GLN A O   1 
ATOM 3671 C CB  . GLN A 1 651 ? 102.667 140.518 139.847 1.00 93.20  ? 651 GLN A CB  1 
ATOM 3672 C CG  . GLN A 1 651 ? 102.787 140.746 138.346 1.00 91.00  ? 651 GLN A CG  1 
ATOM 3673 C CD  . GLN A 1 651 ? 101.556 140.293 137.585 1.00 89.56  ? 651 GLN A CD  1 
ATOM 3674 O OE1 . GLN A 1 651 ? 100.522 139.987 138.179 1.00 90.99  ? 651 GLN A OE1 1 
ATOM 3675 N NE2 . GLN A 1 651 ? 101.662 140.249 136.262 1.00 90.02  ? 651 GLN A NE2 1 
ATOM 3676 N N   . GLY A 1 652 ? 103.344 143.737 141.614 1.00 93.43  ? 652 GLY A N   1 
ATOM 3677 C CA  . GLY A 1 652 ? 104.452 144.576 142.024 1.00 95.75  ? 652 GLY A CA  1 
ATOM 3678 C C   . GLY A 1 652 ? 104.979 145.457 140.910 1.00 95.35  ? 652 GLY A C   1 
ATOM 3679 O O   . GLY A 1 652 ? 105.234 144.980 139.800 1.00 93.35  ? 652 GLY A O   1 
ATOM 3680 N N   . ALA A 1 653 ? 105.155 146.745 141.196 1.00 98.11  ? 653 ALA A N   1 
ATOM 3681 C CA  . ALA A 1 653 ? 105.677 147.688 140.213 1.00 98.23  ? 653 ALA A CA  1 
ATOM 3682 C C   . ALA A 1 653 ? 107.195 147.566 140.173 1.00 94.98  ? 653 ALA A C   1 
ATOM 3683 O O   . ALA A 1 653 ? 107.876 147.857 141.162 1.00 95.12  ? 653 ALA A O   1 
ATOM 3684 C CB  . ALA A 1 653 ? 105.246 149.111 140.555 1.00 96.52  ? 653 ALA A CB  1 
ATOM 3685 N N   . THR A 1 654 ? 107.728 147.138 139.032 1.00 94.77  ? 654 THR A N   1 
ATOM 3686 C CA  . THR A 1 654 ? 109.162 146.922 138.893 1.00 96.62  ? 654 THR A CA  1 
ATOM 3687 C C   . THR A 1 654 ? 109.868 148.256 138.684 1.00 97.45  ? 654 THR A C   1 
ATOM 3688 O O   . THR A 1 654 ? 109.606 148.958 137.702 1.00 94.92  ? 654 THR A O   1 
ATOM 3689 C CB  . THR A 1 654 ? 109.450 145.976 137.729 1.00 95.93  ? 654 THR A CB  1 
ATOM 3690 O OG1 . THR A 1 654 ? 109.054 146.593 136.497 1.00 94.55  ? 654 THR A OG1 1 
ATOM 3691 C CG2 . THR A 1 654 ? 108.689 144.674 137.907 1.00 94.45  ? 654 THR A CG2 1 
ATOM 3692 N N   . GLN A 1 655 ? 110.761 148.602 139.607 1.00 106.06 ? 655 GLN A N   1 
ATOM 3693 C CA  . GLN A 1 655 ? 111.583 149.806 139.517 1.00 105.63 ? 655 GLN A CA  1 
ATOM 3694 C C   . GLN A 1 655 ? 113.043 149.365 139.574 1.00 103.12 ? 655 GLN A C   1 
ATOM 3695 O O   . GLN A 1 655 ? 113.631 149.240 140.651 1.00 102.99 ? 655 GLN A O   1 
ATOM 3696 C CB  . GLN A 1 655 ? 111.242 150.804 140.626 1.00 103.85 ? 655 GLN A CB  1 
ATOM 3697 C CG  . GLN A 1 655 ? 112.043 152.103 140.577 1.00 104.00 ? 655 GLN A CG  1 
ATOM 3698 C CD  . GLN A 1 655 ? 111.862 152.862 139.276 1.00 106.78 ? 655 GLN A CD  1 
ATOM 3699 O OE1 . GLN A 1 655 ? 112.642 152.703 138.335 1.00 109.18 ? 655 GLN A OE1 1 
ATOM 3700 N NE2 . GLN A 1 655 ? 110.830 153.695 139.216 1.00 103.98 ? 655 GLN A NE2 1 
ATOM 3701 N N   . MET A 1 656 ? 113.608 149.116 138.418 1.00 101.74 ? 656 MET A N   1 
ATOM 3702 C CA  . MET A 1 656 ? 114.967 148.713 138.101 1.00 102.50 ? 656 MET A CA  1 
ATOM 3703 C C   . MET A 1 656 ? 115.845 149.937 137.858 1.00 102.46 ? 656 MET A C   1 
ATOM 3704 O O   . MET A 1 656 ? 115.345 151.001 137.482 1.00 102.11 ? 656 MET A O   1 
ATOM 3705 C CB  . MET A 1 656 ? 114.974 147.831 136.858 1.00 102.48 ? 656 MET A CB  1 
ATOM 3706 C CG  . MET A 1 656 ? 114.138 148.396 135.726 1.00 104.29 ? 656 MET A CG  1 
ATOM 3707 S SD  . MET A 1 656 ? 114.134 147.360 134.257 1.00 108.08 ? 656 MET A SD  1 
ATOM 3708 C CE  . MET A 1 656 ? 115.216 148.324 133.211 1.00 103.26 ? 656 MET A CE  1 
ATOM 3709 N N   . PRO A 1 657 ? 117.158 149.834 138.086 1.00 102.13 ? 657 PRO A N   1 
ATOM 3710 C CA  . PRO A 1 657 ? 118.066 150.925 137.702 1.00 99.93  ? 657 PRO A CA  1 
ATOM 3711 C C   . PRO A 1 657 ? 118.365 150.890 136.210 1.00 102.02 ? 657 PRO A C   1 
ATOM 3712 O O   . PRO A 1 657 ? 119.098 150.022 135.725 1.00 105.07 ? 657 PRO A O   1 
ATOM 3713 C CB  . PRO A 1 657 ? 119.318 150.648 138.548 1.00 102.73 ? 657 PRO A CB  1 
ATOM 3714 C CG  . PRO A 1 657 ? 119.272 149.193 138.847 1.00 104.16 ? 657 PRO A CG  1 
ATOM 3715 C CD  . PRO A 1 657 ? 117.825 148.811 138.913 1.00 102.76 ? 657 PRO A CD  1 
ATOM 3716 N N   . LEU A 1 658 ? 117.790 151.839 135.475 1.00 101.30 ? 658 LEU A N   1 
ATOM 3717 C CA  . LEU A 1 658 ? 118.028 151.987 134.044 1.00 101.20 ? 658 LEU A CA  1 
ATOM 3718 C C   . LEU A 1 658 ? 118.585 153.372 133.730 1.00 101.80 ? 658 LEU A C   1 
ATOM 3719 O O   . LEU A 1 658 ? 118.298 153.961 132.684 1.00 102.43 ? 658 LEU A O   1 
ATOM 3720 C CB  . LEU A 1 658 ? 116.759 151.703 133.236 1.00 100.51 ? 658 LEU A CB  1 
ATOM 3721 C CG  . LEU A 1 658 ? 115.477 152.543 133.332 1.00 104.12 ? 658 LEU A CG  1 
ATOM 3722 C CD1 . LEU A 1 658 ? 114.687 152.419 132.037 1.00 102.58 ? 658 LEU A CD1 1 
ATOM 3723 C CD2 . LEU A 1 658 ? 114.607 152.131 134.506 1.00 102.96 ? 658 LEU A CD2 1 
ATOM 3724 N N   . TYR A 1 659 ? 119.406 153.897 134.639 1.00 95.08  ? 659 TYR A N   1 
ATOM 3725 C CA  . TYR A 1 659 ? 119.979 155.226 134.472 1.00 93.52  ? 659 TYR A CA  1 
ATOM 3726 C C   . TYR A 1 659 ? 120.965 155.254 133.309 1.00 93.13  ? 659 TYR A C   1 
ATOM 3727 O O   . TYR A 1 659 ? 121.621 154.255 133.000 1.00 94.46  ? 659 TYR A O   1 
ATOM 3728 C CB  . TYR A 1 659 ? 120.665 155.669 135.766 1.00 93.37  ? 659 TYR A CB  1 
ATOM 3729 C CG  . TYR A 1 659 ? 122.103 155.218 135.902 1.00 96.91  ? 659 TYR A CG  1 
ATOM 3730 C CD1 . TYR A 1 659 ? 122.413 153.885 136.148 1.00 93.44  ? 659 TYR A CD1 1 
ATOM 3731 C CD2 . TYR A 1 659 ? 123.149 156.125 135.795 1.00 94.73  ? 659 TYR A CD2 1 
ATOM 3732 C CE1 . TYR A 1 659 ? 123.726 153.468 136.276 1.00 93.49  ? 659 TYR A CE1 1 
ATOM 3733 C CE2 . TYR A 1 659 ? 124.465 155.717 135.923 1.00 91.91  ? 659 TYR A CE2 1 
ATOM 3734 C CZ  . TYR A 1 659 ? 124.747 154.389 136.162 1.00 93.45  ? 659 TYR A CZ  1 
ATOM 3735 O OH  . TYR A 1 659 ? 126.054 153.980 136.289 1.00 93.49  ? 659 TYR A OH  1 
ATOM 3736 N N   . SER A 1 660 ? 121.052 156.409 132.653 1.00 90.14  ? 660 SER A N   1 
ATOM 3737 C CA  . SER A 1 660 ? 121.887 156.598 131.468 1.00 87.30  ? 660 SER A CA  1 
ATOM 3738 C C   . SER A 1 660 ? 123.000 157.586 131.808 1.00 88.47  ? 660 SER A C   1 
ATOM 3739 O O   . SER A 1 660 ? 122.828 158.802 131.687 1.00 89.10  ? 660 SER A O   1 
ATOM 3740 C CB  . SER A 1 660 ? 121.048 157.078 130.282 1.00 84.54  ? 660 SER A CB  1 
ATOM 3741 O OG  . SER A 1 660 ? 120.027 156.147 129.971 1.00 83.77  ? 660 SER A OG  1 
ATOM 3742 N N   . SER A 1 661 ? 124.142 157.053 132.236 1.00 76.19  ? 661 SER A N   1 
ATOM 3743 C CA  . SER A 1 661 ? 125.333 157.859 132.436 1.00 74.02  ? 661 SER A CA  1 
ATOM 3744 C C   . SER A 1 661 ? 125.875 158.311 131.079 1.00 74.63  ? 661 SER A C   1 
ATOM 3745 O O   . SER A 1 661 ? 125.575 157.698 130.052 1.00 73.91  ? 661 SER A O   1 
ATOM 3746 C CB  . SER A 1 661 ? 126.379 157.051 133.209 1.00 75.86  ? 661 SER A CB  1 
ATOM 3747 O OG  . SER A 1 661 ? 127.704 157.445 132.901 1.00 78.26  ? 661 SER A OG  1 
ATOM 3748 N N   . PRO A 1 662 ? 126.661 159.398 131.043 1.00 72.73  ? 662 PRO A N   1 
ATOM 3749 C CA  . PRO A 1 662 ? 127.246 159.858 129.764 1.00 72.44  ? 662 PRO A CA  1 
ATOM 3750 C C   . PRO A 1 662 ? 128.123 158.838 129.030 1.00 72.19  ? 662 PRO A C   1 
ATOM 3751 O O   . PRO A 1 662 ? 128.562 159.130 127.911 1.00 77.91  ? 662 PRO A O   1 
ATOM 3752 C CB  . PRO A 1 662 ? 128.071 161.082 130.178 1.00 72.58  ? 662 PRO A CB  1 
ATOM 3753 C CG  . PRO A 1 662 ? 127.381 161.609 131.383 1.00 73.53  ? 662 PRO A CG  1 
ATOM 3754 C CD  . PRO A 1 662 ? 126.711 160.450 132.078 1.00 73.99  ? 662 PRO A CD  1 
ATOM 3755 N N   . ILE A 1 663 ? 128.390 157.663 129.613 1.00 73.04  ? 663 ILE A N   1 
ATOM 3756 C CA  . ILE A 1 663 ? 129.110 156.600 128.916 1.00 71.55  ? 663 ILE A CA  1 
ATOM 3757 C C   . ILE A 1 663 ? 128.223 155.763 128.007 1.00 66.97  ? 663 ILE A C   1 
ATOM 3758 O O   . ILE A 1 663 ? 128.718 154.797 127.410 1.00 67.63  ? 663 ILE A O   1 
ATOM 3759 C CB  . ILE A 1 663 ? 129.806 155.680 129.938 1.00 71.63  ? 663 ILE A CB  1 
ATOM 3760 C CG1 . ILE A 1 663 ? 128.769 155.039 130.865 1.00 66.86  ? 663 ILE A CG1 1 
ATOM 3761 C CG2 . ILE A 1 663 ? 130.847 156.455 130.738 1.00 68.36  ? 663 ILE A CG2 1 
ATOM 3762 C CD1 . ILE A 1 663 ? 129.354 154.108 131.903 1.00 64.04  ? 663 ILE A CD1 1 
ATOM 3763 N N   . VAL A 1 664 ? 126.933 156.087 127.884 1.00 64.25  ? 664 VAL A N   1 
ATOM 3764 C CA  . VAL A 1 664 ? 126.016 155.309 127.052 1.00 65.83  ? 664 VAL A CA  1 
ATOM 3765 C C   . VAL A 1 664 ? 125.590 156.059 125.793 1.00 67.20  ? 664 VAL A C   1 
ATOM 3766 O O   . VAL A 1 664 ? 125.108 155.417 124.845 1.00 66.58  ? 664 VAL A O   1 
ATOM 3767 C CB  . VAL A 1 664 ? 124.769 154.859 127.848 1.00 66.51  ? 664 VAL A CB  1 
ATOM 3768 C CG1 . VAL A 1 664 ? 123.744 155.989 127.940 1.00 69.74  ? 664 VAL A CG1 1 
ATOM 3769 C CG2 . VAL A 1 664 ? 124.163 153.573 127.271 1.00 64.68  ? 664 VAL A CG2 1 
ATOM 3770 N N   . LYS A 1 665 ? 125.739 157.376 125.791 1.00 63.40  ? 665 LYS A N   1 
ATOM 3771 C CA  . LYS A 1 665 ? 125.328 158.174 124.649 1.00 63.41  ? 665 LYS A CA  1 
ATOM 3772 C C   . LYS A 1 665 ? 126.520 158.412 123.752 1.00 63.21  ? 665 LYS A C   1 
ATOM 3773 O O   . LYS A 1 665 ? 127.088 159.503 123.745 1.00 62.98  ? 665 LYS A O   1 
ATOM 3774 C CB  . LYS A 1 665 ? 124.750 159.499 125.131 1.00 61.62  ? 665 LYS A CB  1 
ATOM 3775 C CG  . LYS A 1 665 ? 125.098 159.817 126.577 1.00 61.13  ? 665 LYS A CG  1 
ATOM 3776 C CD  . LYS A 1 665 ? 124.024 160.670 127.230 1.00 61.30  ? 665 LYS A CD  1 
ATOM 3777 C CE  . LYS A 1 665 ? 123.928 160.394 128.720 1.00 64.13  ? 665 LYS A CE  1 
ATOM 3778 N NZ  . LYS A 1 665 ? 123.456 159.010 128.986 1.00 64.84  ? 665 LYS A NZ  1 
ATOM 3779 N N   . ASN A 1 666 ? 126.909 157.395 122.993 1.00 67.66  ? 666 ASN A N   1 
ATOM 3780 C CA  . ASN A 1 666 ? 128.089 157.518 122.150 1.00 64.19  ? 666 ASN A CA  1 
ATOM 3781 C C   . ASN A 1 666 ? 128.082 156.490 121.040 1.00 61.55  ? 666 ASN A C   1 
ATOM 3782 O O   . ASN A 1 666 ? 127.552 155.399 121.214 1.00 62.84  ? 666 ASN A O   1 
ATOM 3783 C CB  . ASN A 1 666 ? 129.348 157.338 122.995 1.00 61.08  ? 666 ASN A CB  1 
ATOM 3784 C CG  . ASN A 1 666 ? 129.315 156.068 123.820 1.00 63.37  ? 666 ASN A CG  1 
ATOM 3785 O OD1 . ASN A 1 666 ? 128.403 155.855 124.618 1.00 61.93  ? 666 ASN A OD1 1 
ATOM 3786 N ND2 . ASN A 1 666 ? 130.313 155.216 123.631 1.00 62.72  ? 666 ASN A ND2 1 
ATOM 3787 N N   . PRO A 1 667 ? 128.682 156.829 119.891 1.00 52.48  ? 667 PRO A N   1 
ATOM 3788 C CA  . PRO A 1 667 ? 128.783 155.853 118.806 1.00 44.19  ? 667 PRO A CA  1 
ATOM 3789 C C   . PRO A 1 667 ? 129.433 154.602 119.318 1.00 52.25  ? 667 PRO A C   1 
ATOM 3790 O O   . PRO A 1 667 ? 128.914 153.505 119.109 1.00 48.26  ? 667 PRO A O   1 
ATOM 3791 C CB  . PRO A 1 667 ? 129.746 156.518 117.822 1.00 30.00  ? 667 PRO A CB  1 
ATOM 3792 C CG  . PRO A 1 667 ? 130.430 157.604 118.592 1.00 30.00  ? 667 PRO A CG  1 
ATOM 3793 C CD  . PRO A 1 667 ? 129.423 158.064 119.598 1.00 30.00  ? 667 PRO A CD  1 
ATOM 3794 N N   . PHE A 1 668 ? 130.571 154.767 119.980 1.00 53.13  ? 668 PHE A N   1 
ATOM 3795 C CA  . PHE A 1 668 ? 131.303 153.623 120.491 1.00 52.75  ? 668 PHE A CA  1 
ATOM 3796 C C   . PHE A 1 668 ? 130.378 152.671 121.214 1.00 55.12  ? 668 PHE A C   1 
ATOM 3797 O O   . PHE A 1 668 ? 130.659 151.476 121.292 1.00 60.87  ? 668 PHE A O   1 
ATOM 3798 C CB  . PHE A 1 668 ? 132.430 154.091 121.405 1.00 49.71  ? 668 PHE A CB  1 
ATOM 3799 C CG  . PHE A 1 668 ? 133.397 155.008 120.726 1.00 53.79  ? 668 PHE A CG  1 
ATOM 3800 C CD1 . PHE A 1 668 ? 133.256 156.380 120.826 1.00 49.22  ? 668 PHE A CD1 1 
ATOM 3801 C CD2 . PHE A 1 668 ? 134.433 154.497 119.963 1.00 58.00  ? 668 PHE A CD2 1 
ATOM 3802 C CE1 . PHE A 1 668 ? 134.141 157.229 120.191 1.00 51.21  ? 668 PHE A CE1 1 
ATOM 3803 C CE2 . PHE A 1 668 ? 135.322 155.339 119.326 1.00 53.47  ? 668 PHE A CE2 1 
ATOM 3804 C CZ  . PHE A 1 668 ? 135.176 156.707 119.440 1.00 52.23  ? 668 PHE A CZ  1 
ATOM 3805 N N   . MET A 1 669 ? 129.270 153.178 121.741 1.00 52.61  ? 669 MET A N   1 
ATOM 3806 C CA  . MET A 1 669 ? 128.323 152.246 122.344 1.00 47.99  ? 669 MET A CA  1 
ATOM 3807 C C   . MET A 1 669 ? 127.029 152.117 121.558 1.00 57.00  ? 669 MET A C   1 
ATOM 3808 O O   . MET A 1 669 ? 126.393 151.058 121.619 1.00 61.73  ? 669 MET A O   1 
ATOM 3809 C CB  . MET A 1 669 ? 128.001 152.670 123.787 1.00 46.93  ? 669 MET A CB  1 
ATOM 3810 C CG  . MET A 1 669 ? 127.255 151.629 124.611 1.00 54.26  ? 669 MET A CG  1 
ATOM 3811 S SD  . MET A 1 669 ? 127.450 151.851 126.387 1.00 69.33  ? 669 MET A SD  1 
ATOM 3812 C CE  . MET A 1 669 ? 127.200 150.174 126.963 1.00 47.75  ? 669 MET A CE  1 
ATOM 3813 N N   . SER A 1 670 ? 126.640 153.133 120.796 1.00 55.54  ? 670 SER A N   1 
ATOM 3814 C CA  . SER A 1 670 ? 125.392 153.121 120.035 1.00 47.89  ? 670 SER A CA  1 
ATOM 3815 C C   . SER A 1 670 ? 125.524 154.100 118.867 1.00 44.61  ? 670 SER A C   1 
ATOM 3816 O O   . SER A 1 670 ? 125.351 155.317 119.032 1.00 47.12  ? 670 SER A O   1 
ATOM 3817 C CB  . SER A 1 670 ? 124.205 153.441 120.940 1.00 42.16  ? 670 SER A CB  1 
ATOM 3818 O OG  . SER A 1 670 ? 124.379 154.677 121.597 1.00 36.11  ? 670 SER A OG  1 
ATOM 3819 N N   . PRO A 1 671 ? 125.856 153.601 117.671 1.00 38.38  ? 671 PRO A N   1 
ATOM 3820 C CA  . PRO A 1 671 ? 126.378 154.473 116.608 1.00 47.99  ? 671 PRO A CA  1 
ATOM 3821 C C   . PRO A 1 671 ? 125.337 155.250 115.800 1.00 47.04  ? 671 PRO A C   1 
ATOM 3822 O O   . PRO A 1 671 ? 125.684 155.734 114.716 1.00 44.83  ? 671 PRO A O   1 
ATOM 3823 C CB  . PRO A 1 671 ? 127.163 153.494 115.714 1.00 44.68  ? 671 PRO A CB  1 
ATOM 3824 C CG  . PRO A 1 671 ? 126.612 152.162 116.011 1.00 33.40  ? 671 PRO A CG  1 
ATOM 3825 C CD  . PRO A 1 671 ? 126.136 152.178 117.420 1.00 31.65  ? 671 PRO A CD  1 
ATOM 3826 N N   . LEU A 1 672 ? 124.084 155.392 116.251 1.00 48.43  ? 672 LEU A N   1 
ATOM 3827 C CA  . LEU A 1 672 ? 123.164 156.336 115.604 1.00 54.70  ? 672 LEU A CA  1 
ATOM 3828 C C   . LEU A 1 672 ? 123.384 157.766 116.070 1.00 58.27  ? 672 LEU A C   1 
ATOM 3829 O O   . LEU A 1 672 ? 123.637 158.664 115.261 1.00 68.07  ? 672 LEU A O   1 
ATOM 3830 C CB  . LEU A 1 672 ? 121.699 155.979 115.851 1.00 56.41  ? 672 LEU A CB  1 
ATOM 3831 C CG  . LEU A 1 672 ? 121.006 154.783 115.242 1.00 53.29  ? 672 LEU A CG  1 
ATOM 3832 C CD1 . LEU A 1 672 ? 121.395 154.810 113.797 1.00 49.85  ? 672 LEU A CD1 1 
ATOM 3833 C CD2 . LEU A 1 672 ? 121.298 153.478 115.904 1.00 49.79  ? 672 LEU A CD2 1 
ATOM 3834 N N   . LEU A 1 673 ? 123.260 158.007 117.379 1.00 57.91  ? 673 LEU A N   1 
ATOM 3835 C CA  . LEU A 1 673 ? 123.286 159.358 117.935 1.00 60.75  ? 673 LEU A CA  1 
ATOM 3836 C C   . LEU A 1 673 ? 124.701 159.908 118.046 1.00 58.96  ? 673 LEU A C   1 
ATOM 3837 O O   . LEU A 1 673 ? 124.938 160.926 118.708 1.00 56.19  ? 673 LEU A O   1 
ATOM 3838 C CB  . LEU A 1 673 ? 122.571 159.395 119.295 1.00 55.80  ? 673 LEU A CB  1 
ATOM 3839 C CG  . LEU A 1 673 ? 122.839 158.364 120.397 1.00 53.28  ? 673 LEU A CG  1 
ATOM 3840 C CD1 . LEU A 1 673 ? 124.310 158.300 120.735 1.00 51.40  ? 673 LEU A CD1 1 
ATOM 3841 C CD2 . LEU A 1 673 ? 122.075 158.717 121.613 1.00 56.63  ? 673 LEU A CD2 1 
ATOM 3842 N N   . ALA A 1 674 ? 125.632 159.261 117.355 1.00 57.93  ? 674 ALA A N   1 
ATOM 3843 C CA  . ALA A 1 674 ? 126.985 159.729 117.223 1.00 56.50  ? 674 ALA A CA  1 
ATOM 3844 C C   . ALA A 1 674 ? 127.013 161.040 116.448 1.00 58.81  ? 674 ALA A C   1 
ATOM 3845 O O   . ALA A 1 674 ? 126.061 161.367 115.732 1.00 59.11  ? 674 ALA A O   1 
ATOM 3846 C CB  . ALA A 1 674 ? 127.809 158.676 116.500 1.00 55.63  ? 674 ALA A CB  1 
ATOM 3847 N N   . PRO A 1 675 ? 128.066 161.836 116.629 1.00 69.10  ? 675 PRO A N   1 
ATOM 3848 C CA  . PRO A 1 675 ? 128.240 163.025 115.789 1.00 67.81  ? 675 PRO A CA  1 
ATOM 3849 C C   . PRO A 1 675 ? 128.303 162.650 114.315 1.00 65.94  ? 675 PRO A C   1 
ATOM 3850 O O   . PRO A 1 675 ? 128.852 161.613 113.938 1.00 64.20  ? 675 PRO A O   1 
ATOM 3851 C CB  . PRO A 1 675 ? 129.565 163.622 116.276 1.00 69.43  ? 675 PRO A CB  1 
ATOM 3852 C CG  . PRO A 1 675 ? 129.798 163.045 117.630 1.00 69.01  ? 675 PRO A CG  1 
ATOM 3853 C CD  . PRO A 1 675 ? 128.887 161.883 117.852 1.00 70.59  ? 675 PRO A CD  1 
ATOM 3854 N N   . ASP A 1 676 ? 127.703 163.507 113.490 1.00 64.97  ? 676 ASP A N   1 
ATOM 3855 C CA  . ASP A 1 676 ? 127.516 163.214 112.073 1.00 66.13  ? 676 ASP A CA  1 
ATOM 3856 C C   . ASP A 1 676 ? 128.839 163.207 111.316 1.00 64.86  ? 676 ASP A C   1 
ATOM 3857 O O   . ASP A 1 676 ? 129.029 162.388 110.410 1.00 67.22  ? 676 ASP A O   1 
ATOM 3858 C CB  . ASP A 1 676 ? 126.557 164.246 111.475 1.00 66.97  ? 676 ASP A CB  1 
ATOM 3859 C CG  . ASP A 1 676 ? 126.073 163.879 110.086 1.00 67.04  ? 676 ASP A CG  1 
ATOM 3860 O OD1 . ASP A 1 676 ? 126.338 162.751 109.630 1.00 64.87  ? 676 ASP A OD1 1 
ATOM 3861 O OD2 . ASP A 1 676 ? 125.422 164.732 109.447 1.00 67.04  ? 676 ASP A OD2 1 
ATOM 3862 N N   . SER A 1 677 ? 129.768 164.092 111.686 1.00 71.84  ? 677 SER A N   1 
ATOM 3863 C CA  . SER A 1 677 ? 130.987 164.316 110.916 1.00 71.23  ? 677 SER A CA  1 
ATOM 3864 C C   . SER A 1 677 ? 131.946 163.132 110.933 1.00 69.70  ? 677 SER A C   1 
ATOM 3865 O O   . SER A 1 677 ? 132.886 163.115 110.132 1.00 69.98  ? 677 SER A O   1 
ATOM 3866 C CB  . SER A 1 677 ? 131.709 165.562 111.434 1.00 69.23  ? 677 SER A CB  1 
ATOM 3867 O OG  . SER A 1 677 ? 132.285 165.329 112.708 1.00 69.22  ? 677 SER A OG  1 
ATOM 3868 N N   . MET A 1 678 ? 131.744 162.152 111.813 1.00 68.08  ? 678 MET A N   1 
ATOM 3869 C CA  . MET A 1 678 ? 132.648 161.015 111.886 1.00 71.23  ? 678 MET A CA  1 
ATOM 3870 C C   . MET A 1 678 ? 132.023 159.710 111.403 1.00 69.69  ? 678 MET A C   1 
ATOM 3871 O O   . MET A 1 678 ? 132.704 158.680 111.410 1.00 64.67  ? 678 MET A O   1 
ATOM 3872 C CB  . MET A 1 678 ? 133.211 160.901 113.319 1.00 67.43  ? 678 MET A CB  1 
ATOM 3873 C CG  . MET A 1 678 ? 132.298 160.439 114.472 1.00 66.92  ? 678 MET A CG  1 
ATOM 3874 S SD  . MET A 1 678 ? 131.630 158.763 114.481 1.00 68.32  ? 678 MET A SD  1 
ATOM 3875 C CE  . MET A 1 678 ? 133.137 157.834 114.732 1.00 66.06  ? 678 MET A CE  1 
ATOM 3876 N N   . LEU A 1 679 ? 130.758 159.728 110.973 1.00 63.31  ? 679 LEU A N   1 
ATOM 3877 C CA  . LEU A 1 679 ? 130.163 158.586 110.283 1.00 59.94  ? 679 LEU A CA  1 
ATOM 3878 C C   . LEU A 1 679 ? 130.352 158.643 108.776 1.00 64.87  ? 679 LEU A C   1 
ATOM 3879 O O   . LEU A 1 679 ? 129.831 157.771 108.073 1.00 61.94  ? 679 LEU A O   1 
ATOM 3880 C CB  . LEU A 1 679 ? 128.661 158.479 110.570 1.00 62.74  ? 679 LEU A CB  1 
ATOM 3881 C CG  . LEU A 1 679 ? 128.187 157.625 111.742 1.00 62.17  ? 679 LEU A CG  1 
ATOM 3882 C CD1 . LEU A 1 679 ? 128.453 158.378 112.993 1.00 64.10  ? 679 LEU A CD1 1 
ATOM 3883 C CD2 . LEU A 1 679 ? 126.708 157.297 111.635 1.00 59.54  ? 679 LEU A CD2 1 
ATOM 3884 N N   . LYS A 1 680 ? 131.060 159.651 108.265 1.00 73.97  ? 680 LYS A N   1 
ATOM 3885 C CA  . LYS A 1 680 ? 131.202 159.799 106.820 1.00 72.09  ? 680 LYS A CA  1 
ATOM 3886 C C   . LYS A 1 680 ? 132.131 158.740 106.238 1.00 72.35  ? 680 LYS A C   1 
ATOM 3887 O O   . LYS A 1 680 ? 131.956 158.317 105.090 1.00 72.44  ? 680 LYS A O   1 
ATOM 3888 C CB  . LYS A 1 680 ? 131.710 161.202 106.486 1.00 75.41  ? 680 LYS A CB  1 
ATOM 3889 C CG  . LYS A 1 680 ? 131.158 162.301 107.384 1.00 75.60  ? 680 LYS A CG  1 
ATOM 3890 C CD  . LYS A 1 680 ? 129.663 162.494 107.185 1.00 74.70  ? 680 LYS A CD  1 
ATOM 3891 C CE  . LYS A 1 680 ? 129.372 163.357 105.970 1.00 77.35  ? 680 LYS A CE  1 
ATOM 3892 N NZ  . LYS A 1 680 ? 127.920 163.660 105.842 1.00 79.74  ? 680 LYS A NZ  1 
ATOM 3893 N N   . SER A 1 681 ? 133.122 158.297 107.014 1.00 65.14  ? 681 SER A N   1 
ATOM 3894 C CA  . SER A 1 681 ? 134.095 157.312 106.559 1.00 73.72  ? 681 SER A CA  1 
ATOM 3895 C C   . SER A 1 681 ? 133.674 155.879 106.864 1.00 72.28  ? 681 SER A C   1 
ATOM 3896 O O   . SER A 1 681 ? 134.532 154.990 106.944 1.00 73.20  ? 681 SER A O   1 
ATOM 3897 C CB  . SER A 1 681 ? 135.464 157.604 107.176 1.00 74.71  ? 681 SER A CB  1 
ATOM 3898 O OG  . SER A 1 681 ? 136.382 156.559 106.904 1.00 71.08  ? 681 SER A OG  1 
ATOM 3899 N N   . LEU A 1 682 ? 132.379 155.632 107.045 1.00 51.89  ? 682 LEU A N   1 
ATOM 3900 C CA  . LEU A 1 682 ? 131.905 154.286 107.310 1.00 46.16  ? 682 LEU A CA  1 
ATOM 3901 C C   . LEU A 1 682 ? 132.047 153.417 106.062 1.00 48.41  ? 682 LEU A C   1 
ATOM 3902 O O   . LEU A 1 682 ? 131.918 153.905 104.937 1.00 52.60  ? 682 LEU A O   1 
ATOM 3903 C CB  . LEU A 1 682 ? 130.445 154.312 107.757 1.00 46.98  ? 682 LEU A CB  1 
ATOM 3904 C CG  . LEU A 1 682 ? 129.960 153.272 108.772 1.00 45.28  ? 682 LEU A CG  1 
ATOM 3905 C CD1 . LEU A 1 682 ? 130.805 153.289 110.030 1.00 35.46  ? 682 LEU A CD1 1 
ATOM 3906 C CD2 . LEU A 1 682 ? 128.499 153.496 109.109 1.00 49.19  ? 682 LEU A CD2 1 
ATOM 3907 N N   . PRO A 1 683 ? 132.332 152.130 106.234 1.00 39.63  ? 683 PRO A N   1 
ATOM 3908 C CA  . PRO A 1 683 ? 132.295 151.200 105.103 1.00 40.95  ? 683 PRO A CA  1 
ATOM 3909 C C   . PRO A 1 683 ? 130.870 150.984 104.630 1.00 50.63  ? 683 PRO A C   1 
ATOM 3910 O O   . PRO A 1 683 ? 129.919 151.296 105.362 1.00 57.47  ? 683 PRO A O   1 
ATOM 3911 C CB  . PRO A 1 683 ? 132.884 149.910 105.690 1.00 40.06  ? 683 PRO A CB  1 
ATOM 3912 C CG  . PRO A 1 683 ? 132.743 150.056 107.164 1.00 34.17  ? 683 PRO A CG  1 
ATOM 3913 C CD  . PRO A 1 683 ? 132.890 151.505 107.443 1.00 37.09  ? 683 PRO A CD  1 
ATOM 3914 N N   . PRO A 1 684 ? 130.677 150.497 103.402 1.00 52.07  ? 684 PRO A N   1 
ATOM 3915 C CA  . PRO A 1 684 ? 129.332 150.087 102.974 1.00 44.04  ? 684 PRO A CA  1 
ATOM 3916 C C   . PRO A 1 684 ? 128.783 148.986 103.869 1.00 36.94  ? 684 PRO A C   1 
ATOM 3917 O O   . PRO A 1 684 ? 129.504 148.072 104.273 1.00 32.37  ? 684 PRO A O   1 
ATOM 3918 C CB  . PRO A 1 684 ? 129.554 149.599 101.540 1.00 42.68  ? 684 PRO A CB  1 
ATOM 3919 C CG  . PRO A 1 684 ? 130.736 150.360 101.076 1.00 47.25  ? 684 PRO A CG  1 
ATOM 3920 C CD  . PRO A 1 684 ? 131.627 150.513 102.278 1.00 49.26  ? 684 PRO A CD  1 
ATOM 3921 N N   . VAL A 1 685 ? 127.494 149.083 104.177 1.00 43.85  ? 685 VAL A N   1 
ATOM 3922 C CA  . VAL A 1 685 ? 126.857 148.264 105.199 1.00 45.54  ? 685 VAL A CA  1 
ATOM 3923 C C   . VAL A 1 685 ? 125.734 147.463 104.562 1.00 49.37  ? 685 VAL A C   1 
ATOM 3924 O O   . VAL A 1 685 ? 124.890 148.023 103.853 1.00 44.89  ? 685 VAL A O   1 
ATOM 3925 C CB  . VAL A 1 685 ? 126.315 149.126 106.352 1.00 49.44  ? 685 VAL A CB  1 
ATOM 3926 C CG1 . VAL A 1 685 ? 125.588 148.263 107.354 1.00 43.38  ? 685 VAL A CG1 1 
ATOM 3927 C CG2 . VAL A 1 685 ? 127.438 149.891 107.009 1.00 38.48  ? 685 VAL A CG2 1 
ATOM 3928 N N   . HIS A 1 686 ? 125.724 146.159 104.816 1.00 29.18  ? 686 HIS A N   1 
ATOM 3929 C CA  . HIS A 1 686 ? 124.629 145.283 104.428 1.00 35.95  ? 686 HIS A CA  1 
ATOM 3930 C C   . HIS A 1 686 ? 124.004 144.740 105.707 1.00 40.34  ? 686 HIS A C   1 
ATOM 3931 O O   . HIS A 1 686 ? 124.705 144.167 106.546 1.00 38.69  ? 686 HIS A O   1 
ATOM 3932 C CB  . HIS A 1 686 ? 125.126 144.157 103.524 1.00 37.72  ? 686 HIS A CB  1 
ATOM 3933 C CG  . HIS A 1 686 ? 125.649 144.631 102.203 1.00 37.15  ? 686 HIS A CG  1 
ATOM 3934 N ND1 . HIS A 1 686 ? 125.251 144.080 101.005 1.00 45.54  ? 686 HIS A ND1 1 
ATOM 3935 C CD2 . HIS A 1 686 ? 126.544 145.598 101.891 1.00 35.51  ? 686 HIS A CD2 1 
ATOM 3936 C CE1 . HIS A 1 686 ? 125.873 144.691 100.013 1.00 47.56  ? 686 HIS A CE1 1 
ATOM 3937 N NE2 . HIS A 1 686 ? 126.663 145.617 100.524 1.00 39.80  ? 686 HIS A NE2 1 
ATOM 3938 N N   . ILE A 1 687 ? 122.699 144.936 105.864 1.00 42.78  ? 687 ILE A N   1 
ATOM 3939 C CA  . ILE A 1 687 ? 122.022 144.677 107.130 1.00 43.99  ? 687 ILE A CA  1 
ATOM 3940 C C   . ILE A 1 687 ? 120.696 143.976 106.857 1.00 50.82  ? 687 ILE A C   1 
ATOM 3941 O O   . ILE A 1 687 ? 120.003 144.289 105.882 1.00 44.20  ? 687 ILE A O   1 
ATOM 3942 C CB  . ILE A 1 687 ? 121.840 145.992 107.927 1.00 35.99  ? 687 ILE A CB  1 
ATOM 3943 C CG1 . ILE A 1 687 ? 121.263 145.748 109.319 1.00 30.79  ? 687 ILE A CG1 1 
ATOM 3944 C CG2 . ILE A 1 687 ? 121.030 147.030 107.162 1.00 40.02  ? 687 ILE A CG2 1 
ATOM 3945 C CD1 . ILE A 1 687 ? 121.564 146.881 110.254 1.00 42.14  ? 687 ILE A CD1 1 
ATOM 3946 N N   . VAL A 1 688 ? 120.367 142.985 107.692 1.00 52.78  ? 688 VAL A N   1 
ATOM 3947 C CA  . VAL A 1 688 ? 119.097 142.274 107.614 1.00 47.30  ? 688 VAL A CA  1 
ATOM 3948 C C   . VAL A 1 688 ? 118.472 142.209 109.002 1.00 46.88  ? 688 VAL A C   1 
ATOM 3949 O O   . VAL A 1 688 ? 119.154 142.294 110.026 1.00 46.41  ? 688 VAL A O   1 
ATOM 3950 C CB  . VAL A 1 688 ? 119.238 140.849 107.030 1.00 38.83  ? 688 VAL A CB  1 
ATOM 3951 C CG1 . VAL A 1 688 ? 119.755 140.893 105.604 1.00 37.25  ? 688 VAL A CG1 1 
ATOM 3952 C CG2 . VAL A 1 688 ? 120.143 140.003 107.895 1.00 41.06  ? 688 VAL A CG2 1 
ATOM 3953 N N   . ALA A 1 689 ? 117.149 142.054 109.020 1.00 40.67  ? 689 ALA A N   1 
ATOM 3954 C CA  . ALA A 1 689 ? 116.381 141.938 110.254 1.00 39.37  ? 689 ALA A CA  1 
ATOM 3955 C C   . ALA A 1 689 ? 115.050 141.278 109.925 1.00 44.92  ? 689 ALA A C   1 
ATOM 3956 O O   . ALA A 1 689 ? 114.740 141.014 108.763 1.00 45.08  ? 689 ALA A O   1 
ATOM 3957 C CB  . ALA A 1 689 ? 116.167 143.303 110.916 1.00 41.08  ? 689 ALA A CB  1 
ATOM 3958 N N   . CYS A 1 690 ? 114.267 141.005 110.965 1.00 51.02  ? 690 CYS A N   1 
ATOM 3959 C CA  . CYS A 1 690 ? 112.916 140.490 110.786 1.00 54.16  ? 690 CYS A CA  1 
ATOM 3960 C C   . CYS A 1 690 ? 111.892 141.550 111.175 1.00 49.04  ? 690 CYS A C   1 
ATOM 3961 O O   . CYS A 1 690 ? 112.197 142.517 111.876 1.00 54.17  ? 690 CYS A O   1 
ATOM 3962 C CB  . CYS A 1 690 ? 112.680 139.222 111.610 1.00 50.43  ? 690 CYS A CB  1 
ATOM 3963 S SG  . CYS A 1 690 ? 114.080 138.104 111.697 1.00 38.55  ? 690 CYS A SG  1 
ATOM 3964 N N   . ALA A 1 691 ? 110.658 141.345 110.717 1.00 40.20  ? 691 ALA A N   1 
ATOM 3965 C CA  . ALA A 1 691 ? 109.600 142.320 110.937 1.00 45.91  ? 691 ALA A CA  1 
ATOM 3966 C C   . ALA A 1 691 ? 109.026 142.286 112.347 1.00 40.20  ? 691 ALA A C   1 
ATOM 3967 O O   . ALA A 1 691 ? 108.322 143.227 112.727 1.00 38.10  ? 691 ALA A O   1 
ATOM 3968 C CB  . ALA A 1 691 ? 108.471 142.106 109.927 1.00 47.96  ? 691 ALA A CB  1 
ATOM 3969 N N   . LEU A 1 692 ? 109.304 141.248 113.130 1.00 41.92  ? 692 LEU A N   1 
ATOM 3970 C CA  . LEU A 1 692 ? 108.700 141.083 114.450 1.00 49.33  ? 692 LEU A CA  1 
ATOM 3971 C C   . LEU A 1 692 ? 109.772 140.896 115.514 1.00 46.33  ? 692 LEU A C   1 
ATOM 3972 O O   . LEU A 1 692 ? 109.692 140.013 116.371 1.00 55.24  ? 692 LEU A O   1 
ATOM 3973 C CB  . LEU A 1 692 ? 107.718 139.914 114.464 1.00 50.54  ? 692 LEU A CB  1 
ATOM 3974 C CG  . LEU A 1 692 ? 106.556 139.996 113.471 1.00 45.90  ? 692 LEU A CG  1 
ATOM 3975 C CD1 . LEU A 1 692 ? 106.796 139.087 112.274 1.00 48.76  ? 692 LEU A CD1 1 
ATOM 3976 C CD2 . LEU A 1 692 ? 105.240 139.665 114.148 1.00 42.26  ? 692 LEU A CD2 1 
ATOM 3977 N N   . ASP A 1 693 ? 110.794 141.739 115.475 1.00 35.76  ? 693 ASP A N   1 
ATOM 3978 C CA  . ASP A 1 693 ? 111.815 141.781 116.505 1.00 38.54  ? 693 ASP A CA  1 
ATOM 3979 C C   . ASP A 1 693 ? 111.738 143.093 117.266 1.00 43.82  ? 693 ASP A C   1 
ATOM 3980 O O   . ASP A 1 693 ? 111.273 144.105 116.733 1.00 48.87  ? 693 ASP A O   1 
ATOM 3981 C CB  . ASP A 1 693 ? 113.222 141.654 115.910 1.00 44.92  ? 693 ASP A CB  1 
ATOM 3982 C CG  . ASP A 1 693 ? 113.298 140.667 114.775 1.00 50.15  ? 693 ASP A CG  1 
ATOM 3983 O OD1 . ASP A 1 693 ? 112.564 139.657 114.801 1.00 59.20  ? 693 ASP A OD1 1 
ATOM 3984 O OD2 . ASP A 1 693 ? 114.127 140.893 113.870 1.00 48.01  ? 693 ASP A OD2 1 
ATOM 3985 N N   . PRO A 1 694 ? 112.170 143.113 118.527 1.00 46.22  ? 694 PRO A N   1 
ATOM 3986 C CA  . PRO A 1 694 ? 112.458 144.406 119.165 1.00 47.98  ? 694 PRO A CA  1 
ATOM 3987 C C   . PRO A 1 694 ? 113.617 145.136 118.504 1.00 53.24  ? 694 PRO A C   1 
ATOM 3988 O O   . PRO A 1 694 ? 113.660 146.372 118.532 1.00 51.91  ? 694 PRO A O   1 
ATOM 3989 C CB  . PRO A 1 694 ? 112.770 144.022 120.619 1.00 52.48  ? 694 PRO A CB  1 
ATOM 3990 C CG  . PRO A 1 694 ? 112.195 142.656 120.795 1.00 56.64  ? 694 PRO A CG  1 
ATOM 3991 C CD  . PRO A 1 694 ? 112.313 141.989 119.464 1.00 50.23  ? 694 PRO A CD  1 
ATOM 3992 N N   . MET A 1 695 ? 114.565 144.402 117.921 1.00 61.77  ? 695 MET A N   1 
ATOM 3993 C CA  . MET A 1 695 ? 115.659 144.954 117.113 1.00 53.50  ? 695 MET A CA  1 
ATOM 3994 C C   . MET A 1 695 ? 115.225 145.216 115.676 1.00 52.84  ? 695 MET A C   1 
ATOM 3995 O O   . MET A 1 695 ? 115.875 144.788 114.725 1.00 52.71  ? 695 MET A O   1 
ATOM 3996 C CB  . MET A 1 695 ? 116.862 144.014 117.141 1.00 52.27  ? 695 MET A CB  1 
ATOM 3997 C CG  . MET A 1 695 ? 117.490 143.679 118.497 1.00 52.64  ? 695 MET A CG  1 
ATOM 3998 S SD  . MET A 1 695 ? 117.474 145.014 119.710 1.00 65.27  ? 695 MET A SD  1 
ATOM 3999 C CE  . MET A 1 695 ? 116.052 144.624 120.698 1.00 58.07  ? 695 MET A CE  1 
ATOM 4000 N N   . LEU A 1 696 ? 114.119 145.932 115.510 1.00 45.61  ? 696 LEU A N   1 
ATOM 4001 C CA  . LEU A 1 696 ? 113.652 146.329 114.191 1.00 41.59  ? 696 LEU A CA  1 
ATOM 4002 C C   . LEU A 1 696 ? 113.634 147.837 114.025 1.00 43.20  ? 696 LEU A C   1 
ATOM 4003 O O   . LEU A 1 696 ? 114.125 148.348 113.013 1.00 49.06  ? 696 LEU A O   1 
ATOM 4004 C CB  . LEU A 1 696 ? 112.257 145.752 113.921 1.00 46.24  ? 696 LEU A CB  1 
ATOM 4005 C CG  . LEU A 1 696 ? 111.494 146.396 112.767 1.00 50.92  ? 696 LEU A CG  1 
ATOM 4006 C CD1 . LEU A 1 696 ? 111.945 145.821 111.438 1.00 41.49  ? 696 LEU A CD1 1 
ATOM 4007 C CD2 . LEU A 1 696 ? 110.008 146.192 112.964 1.00 52.55  ? 696 LEU A CD2 1 
ATOM 4008 N N   . ASP A 1 697 ? 113.091 148.568 114.999 1.00 44.60  ? 697 ASP A N   1 
ATOM 4009 C CA  . ASP A 1 697 ? 113.122 150.024 114.926 1.00 50.43  ? 697 ASP A CA  1 
ATOM 4010 C C   . ASP A 1 697 ? 114.534 150.558 115.103 1.00 53.46  ? 697 ASP A C   1 
ATOM 4011 O O   . ASP A 1 697 ? 114.860 151.636 114.592 1.00 51.93  ? 697 ASP A O   1 
ATOM 4012 C CB  . ASP A 1 697 ? 112.194 150.627 115.976 1.00 56.55  ? 697 ASP A CB  1 
ATOM 4013 C CG  . ASP A 1 697 ? 111.553 151.901 115.501 1.00 59.50  ? 697 ASP A CG  1 
ATOM 4014 O OD1 . ASP A 1 697 ? 110.898 152.595 116.305 1.00 57.81  ? 697 ASP A OD1 1 
ATOM 4015 O OD2 . ASP A 1 697 ? 111.715 152.201 114.304 1.00 61.94  ? 697 ASP A OD2 1 
ATOM 4016 N N   . ASP A 1 698 ? 115.373 149.826 115.837 1.00 69.20  ? 698 ASP A N   1 
ATOM 4017 C CA  . ASP A 1 698 ? 116.771 150.208 115.997 1.00 65.03  ? 698 ASP A CA  1 
ATOM 4018 C C   . ASP A 1 698 ? 117.509 150.146 114.666 1.00 52.86  ? 698 ASP A C   1 
ATOM 4019 O O   . ASP A 1 698 ? 118.248 151.069 114.307 1.00 56.16  ? 698 ASP A O   1 
ATOM 4020 C CB  . ASP A 1 698 ? 117.434 149.290 117.022 1.00 60.60  ? 698 ASP A CB  1 
ATOM 4021 C CG  . ASP A 1 698 ? 116.665 149.226 118.328 1.00 65.23  ? 698 ASP A CG  1 
ATOM 4022 O OD1 . ASP A 1 698 ? 115.622 149.903 118.439 1.00 65.12  ? 698 ASP A OD1 1 
ATOM 4023 O OD2 . ASP A 1 698 ? 117.109 148.504 119.246 1.00 61.81  ? 698 ASP A OD2 1 
ATOM 4024 N N   . SER A 1 699 ? 117.305 149.065 113.913 1.00 38.16  ? 699 SER A N   1 
ATOM 4025 C CA  . SER A 1 699 ? 117.967 148.918 112.623 1.00 38.87  ? 699 SER A CA  1 
ATOM 4026 C C   . SER A 1 699 ? 117.355 149.822 111.560 1.00 45.95  ? 699 SER A C   1 
ATOM 4027 O O   . SER A 1 699 ? 118.031 150.170 110.586 1.00 52.34  ? 699 SER A O   1 
ATOM 4028 C CB  . SER A 1 699 ? 117.906 147.459 112.175 1.00 41.73  ? 699 SER A CB  1 
ATOM 4029 O OG  . SER A 1 699 ? 118.308 147.322 110.825 1.00 51.96  ? 699 SER A OG  1 
ATOM 4030 N N   . VAL A 1 700 ? 116.082 150.193 111.714 1.00 55.01  ? 700 VAL A N   1 
ATOM 4031 C CA  . VAL A 1 700 ? 115.432 151.056 110.730 1.00 53.94  ? 700 VAL A CA  1 
ATOM 4032 C C   . VAL A 1 700 ? 116.002 152.469 110.800 1.00 55.06  ? 700 VAL A C   1 
ATOM 4033 O O   . VAL A 1 700 ? 116.216 153.117 109.767 1.00 53.89  ? 700 VAL A O   1 
ATOM 4034 C CB  . VAL A 1 700 ? 113.903 151.019 110.926 1.00 44.26  ? 700 VAL A CB  1 
ATOM 4035 C CG1 . VAL A 1 700 ? 113.229 152.273 110.392 1.00 47.82  ? 700 VAL A CG1 1 
ATOM 4036 C CG2 . VAL A 1 700 ? 113.329 149.803 110.228 1.00 51.08  ? 700 VAL A CG2 1 
ATOM 4037 N N   . MET A 1 701 ? 116.303 152.949 112.011 1.00 51.12  ? 701 MET A N   1 
ATOM 4038 C CA  . MET A 1 701 ? 116.877 154.283 112.171 1.00 52.86  ? 701 MET A CA  1 
ATOM 4039 C C   . MET A 1 701 ? 118.273 154.384 111.559 1.00 58.62  ? 701 MET A C   1 
ATOM 4040 O O   . MET A 1 701 ? 118.723 155.488 111.228 1.00 56.60  ? 701 MET A O   1 
ATOM 4041 C CB  . MET A 1 701 ? 116.917 154.656 113.653 1.00 52.35  ? 701 MET A CB  1 
ATOM 4042 C CG  . MET A 1 701 ? 115.670 155.368 114.157 1.00 55.09  ? 701 MET A CG  1 
ATOM 4043 S SD  . MET A 1 701 ? 115.281 156.867 113.234 0.53 55.14  ? 701 MET A SD  1 
ATOM 4044 C CE  . MET A 1 701 ? 116.352 158.050 114.045 1.00 53.03  ? 701 MET A CE  1 
ATOM 4045 N N   . LEU A 1 702 ? 118.971 153.253 111.410 1.00 58.34  ? 702 LEU A N   1 
ATOM 4046 C CA  . LEU A 1 702 ? 120.283 153.249 110.765 1.00 55.64  ? 702 LEU A CA  1 
ATOM 4047 C C   . LEU A 1 702 ? 120.204 153.675 109.306 1.00 57.40  ? 702 LEU A C   1 
ATOM 4048 O O   . LEU A 1 702 ? 121.033 154.466 108.844 1.00 57.63  ? 702 LEU A O   1 
ATOM 4049 C CB  . LEU A 1 702 ? 120.919 151.864 110.890 1.00 57.56  ? 702 LEU A CB  1 
ATOM 4050 C CG  . LEU A 1 702 ? 122.110 151.680 111.829 1.00 58.09  ? 702 LEU A CG  1 
ATOM 4051 C CD1 . LEU A 1 702 ? 122.612 150.260 111.733 1.00 53.96  ? 702 LEU A CD1 1 
ATOM 4052 C CD2 . LEU A 1 702 ? 123.220 152.627 111.411 1.00 56.14  ? 702 LEU A CD2 1 
ATOM 4053 N N   . ALA A 1 703 ? 119.218 153.167 108.566 1.00 65.16  ? 703 ALA A N   1 
ATOM 4054 C CA  . ALA A 1 703 ? 119.105 153.516 107.154 1.00 66.63  ? 703 ALA A CA  1 
ATOM 4055 C C   . ALA A 1 703 ? 118.758 154.989 106.967 1.00 69.14  ? 703 ALA A C   1 
ATOM 4056 O O   . ALA A 1 703 ? 119.289 155.644 106.063 1.00 72.17  ? 703 ALA A O   1 
ATOM 4057 C CB  . ALA A 1 703 ? 118.068 152.625 106.473 1.00 68.46  ? 703 ALA A CB  1 
ATOM 4058 N N   . ARG A 1 704 ? 117.882 155.533 107.818 1.00 61.90  ? 704 ARG A N   1 
ATOM 4059 C CA  . ARG A 1 704 ? 117.504 156.938 107.691 1.00 62.94  ? 704 ARG A CA  1 
ATOM 4060 C C   . ARG A 1 704 ? 118.644 157.876 108.064 1.00 69.71  ? 704 ARG A C   1 
ATOM 4061 O O   . ARG A 1 704 ? 118.754 158.969 107.496 1.00 73.20  ? 704 ARG A O   1 
ATOM 4062 C CB  . ARG A 1 704 ? 116.278 157.244 108.551 1.00 61.96  ? 704 ARG A CB  1 
ATOM 4063 C CG  . ARG A 1 704 ? 115.333 156.075 108.730 1.00 64.43  ? 704 ARG A CG  1 
ATOM 4064 C CD  . ARG A 1 704 ? 113.966 156.525 109.224 1.00 69.79  ? 704 ARG A CD  1 
ATOM 4065 N NE  . ARG A 1 704 ? 113.240 157.318 108.239 1.00 68.30  ? 704 ARG A NE  1 
ATOM 4066 C CZ  . ARG A 1 704 ? 113.085 158.633 108.299 1.00 60.33  ? 704 ARG A CZ  1 
ATOM 4067 N NH1 . ARG A 1 704 ? 113.588 159.344 109.294 1.00 65.62  ? 704 ARG A NH1 1 
ATOM 4068 N NH2 . ARG A 1 704 ? 112.405 159.250 107.338 1.00 65.57  ? 704 ARG A NH2 1 
ATOM 4069 N N   . ARG A 1 705 ? 119.496 157.479 109.008 1.00 67.16  ? 705 ARG A N   1 
ATOM 4070 C CA  . ARG A 1 705 ? 120.592 158.345 109.418 1.00 62.85  ? 705 ARG A CA  1 
ATOM 4071 C C   . ARG A 1 705 ? 121.800 158.258 108.497 1.00 58.61  ? 705 ARG A C   1 
ATOM 4072 O O   . ARG A 1 705 ? 122.749 159.025 108.682 1.00 64.97  ? 705 ARG A O   1 
ATOM 4073 C CB  . ARG A 1 705 ? 121.017 158.025 110.850 1.00 60.40  ? 705 ARG A CB  1 
ATOM 4074 C CG  . ARG A 1 705 ? 120.292 158.854 111.889 1.00 65.50  ? 705 ARG A CG  1 
ATOM 4075 C CD  . ARG A 1 705 ? 121.133 159.033 113.133 1.00 63.38  ? 705 ARG A CD  1 
ATOM 4076 N NE  . ARG A 1 705 ? 122.555 159.086 112.820 1.00 63.98  ? 705 ARG A NE  1 
ATOM 4077 C CZ  . ARG A 1 705 ? 123.233 160.205 112.602 1.00 69.25  ? 705 ARG A CZ  1 
ATOM 4078 N NH1 . ARG A 1 705 ? 122.650 161.390 112.666 1.00 67.54  ? 705 ARG A NH1 1 
ATOM 4079 N NH2 . ARG A 1 705 ? 124.530 160.132 112.318 1.00 64.44  ? 705 ARG A NH2 1 
ATOM 4080 N N   . LEU A 1 706 ? 121.793 157.354 107.515 1.00 56.33  ? 706 LEU A N   1 
ATOM 4081 C CA  . LEU A 1 706 ? 122.860 157.284 106.529 1.00 63.84  ? 706 LEU A CA  1 
ATOM 4082 C C   . LEU A 1 706 ? 122.400 157.541 105.102 1.00 66.50  ? 706 LEU A C   1 
ATOM 4083 O O   . LEU A 1 706 ? 123.252 157.761 104.234 1.00 66.05  ? 706 LEU A O   1 
ATOM 4084 C CB  . LEU A 1 706 ? 123.569 155.921 106.581 1.00 66.41  ? 706 LEU A CB  1 
ATOM 4085 C CG  . LEU A 1 706 ? 124.040 155.402 107.940 1.00 64.52  ? 706 LEU A CG  1 
ATOM 4086 C CD1 . LEU A 1 706 ? 124.284 153.901 107.888 1.00 62.41  ? 706 LEU A CD1 1 
ATOM 4087 C CD2 . LEU A 1 706 ? 125.292 156.132 108.386 1.00 65.29  ? 706 LEU A CD2 1 
ATOM 4088 N N   . ARG A 1 707 ? 121.095 157.518 104.826 1.00 71.80  ? 707 ARG A N   1 
ATOM 4089 C CA  . ARG A 1 707 ? 120.626 157.860 103.489 1.00 74.21  ? 707 ARG A CA  1 
ATOM 4090 C C   . ARG A 1 707 ? 120.547 159.364 103.265 1.00 75.84  ? 707 ARG A C   1 
ATOM 4091 O O   . ARG A 1 707 ? 120.431 159.800 102.115 1.00 72.36  ? 707 ARG A O   1 
ATOM 4092 C CB  . ARG A 1 707 ? 119.259 157.227 103.218 1.00 70.08  ? 707 ARG A CB  1 
ATOM 4093 C CG  . ARG A 1 707 ? 119.322 155.765 102.796 1.00 69.51  ? 707 ARG A CG  1 
ATOM 4094 C CD  . ARG A 1 707 ? 120.359 155.535 101.709 1.00 70.66  ? 707 ARG A CD  1 
ATOM 4095 N NE  . ARG A 1 707 ? 119.762 155.522 100.379 1.00 72.22  ? 707 ARG A NE  1 
ATOM 4096 C CZ  . ARG A 1 707 ? 119.249 154.445 99.802  1.00 72.19  ? 707 ARG A CZ  1 
ATOM 4097 N NH1 . ARG A 1 707 ? 119.238 153.272 100.413 1.00 76.13  ? 707 ARG A NH1 1 
ATOM 4098 N NH2 . ARG A 1 707 ? 118.733 154.547 98.580  1.00 72.31  ? 707 ARG A NH2 1 
ATOM 4099 N N   . ASN A 1 708 ? 120.606 160.161 104.330 1.00 80.14  ? 708 ASN A N   1 
ATOM 4100 C CA  . ASN A 1 708 ? 120.694 161.609 104.210 1.00 77.33  ? 708 ASN A CA  1 
ATOM 4101 C C   . ASN A 1 708 ? 122.133 162.100 104.124 1.00 83.64  ? 708 ASN A C   1 
ATOM 4102 O O   . ASN A 1 708 ? 122.357 163.313 104.059 1.00 90.22  ? 708 ASN A O   1 
ATOM 4103 C CB  . ASN A 1 708 ? 119.978 162.287 105.387 1.00 78.91  ? 708 ASN A CB  1 
ATOM 4104 C CG  . ASN A 1 708 ? 120.270 161.619 106.718 1.00 80.98  ? 708 ASN A CG  1 
ATOM 4105 O OD1 . ASN A 1 708 ? 121.265 160.912 106.869 1.00 79.01  ? 708 ASN A OD1 1 
ATOM 4106 N ND2 . ASN A 1 708 ? 119.399 161.845 107.694 1.00 80.48  ? 708 ASN A ND2 1 
ATOM 4107 N N   . LEU A 1 709 ? 123.108 161.189 104.125 1.00 69.36  ? 709 LEU A N   1 
ATOM 4108 C CA  . LEU A 1 709 ? 124.515 161.542 104.016 1.00 68.82  ? 709 LEU A CA  1 
ATOM 4109 C C   . LEU A 1 709 ? 125.153 161.086 102.712 1.00 68.34  ? 709 LEU A C   1 
ATOM 4110 O O   . LEU A 1 709 ? 126.286 161.487 102.425 1.00 67.77  ? 709 LEU A O   1 
ATOM 4111 C CB  . LEU A 1 709 ? 125.306 160.946 105.189 1.00 65.70  ? 709 LEU A CB  1 
ATOM 4112 C CG  . LEU A 1 709 ? 124.670 161.025 106.574 1.00 65.00  ? 709 LEU A CG  1 
ATOM 4113 C CD1 . LEU A 1 709 ? 125.557 160.327 107.584 1.00 69.19  ? 709 LEU A CD1 1 
ATOM 4114 C CD2 . LEU A 1 709 ? 124.432 162.470 106.970 1.00 64.61  ? 709 LEU A CD2 1 
ATOM 4115 N N   . GLY A 1 710 ? 124.467 160.262 101.922 1.00 55.60  ? 710 GLY A N   1 
ATOM 4116 C CA  . GLY A 1 710 ? 124.995 159.748 100.681 1.00 59.48  ? 710 GLY A CA  1 
ATOM 4117 C C   . GLY A 1 710 ? 125.623 158.374 100.785 1.00 63.29  ? 710 GLY A C   1 
ATOM 4118 O O   . GLY A 1 710 ? 125.861 157.738 99.752  1.00 62.09  ? 710 GLY A O   1 
ATOM 4119 N N   . GLN A 1 711 ? 125.899 157.906 101.996 1.00 64.28  ? 711 GLN A N   1 
ATOM 4120 C CA  . GLN A 1 711 ? 126.459 156.572 102.172 1.00 62.37  ? 711 GLN A CA  1 
ATOM 4121 C C   . GLN A 1 711 ? 125.387 155.526 101.891 1.00 66.26  ? 711 GLN A C   1 
ATOM 4122 O O   . GLN A 1 711 ? 124.272 155.635 102.413 1.00 67.54  ? 711 GLN A O   1 
ATOM 4123 C CB  . GLN A 1 711 ? 127.005 156.403 103.588 1.00 60.41  ? 711 GLN A CB  1 
ATOM 4124 C CG  . GLN A 1 711 ? 127.893 155.182 103.767 1.00 65.77  ? 711 GLN A CG  1 
ATOM 4125 C CD  . GLN A 1 711 ? 127.128 153.963 104.240 1.00 66.34  ? 711 GLN A CD  1 
ATOM 4126 O OE1 . GLN A 1 711 ? 126.412 154.013 105.239 1.00 67.59  ? 711 GLN A OE1 1 
ATOM 4127 N NE2 . GLN A 1 711 ? 127.270 152.860 103.516 1.00 59.67  ? 711 GLN A NE2 1 
ATOM 4128 N N   . PRO A 1 712 ? 125.675 154.509 101.081 1.00 71.57  ? 712 PRO A N   1 
ATOM 4129 C CA  . PRO A 1 712 ? 124.649 153.502 100.783 1.00 73.54  ? 712 PRO A CA  1 
ATOM 4130 C C   . PRO A 1 712 ? 124.572 152.400 101.828 1.00 70.89  ? 712 PRO A C   1 
ATOM 4131 O O   . PRO A 1 712 ? 125.591 151.817 102.208 1.00 69.48  ? 712 PRO A O   1 
ATOM 4132 C CB  . PRO A 1 712 ? 125.087 152.952 99.420  1.00 75.48  ? 712 PRO A CB  1 
ATOM 4133 C CG  . PRO A 1 712 ? 126.569 153.174 99.371  1.00 71.39  ? 712 PRO A CG  1 
ATOM 4134 C CD  . PRO A 1 712 ? 126.928 154.269 100.344 1.00 67.41  ? 712 PRO A CD  1 
ATOM 4135 N N   . VAL A 1 713 ? 123.363 152.117 102.304 1.00 53.02  ? 713 VAL A N   1 
ATOM 4136 C CA  . VAL A 1 713 ? 123.103 150.981 103.181 1.00 46.73  ? 713 VAL A CA  1 
ATOM 4137 C C   . VAL A 1 713 ? 121.840 150.287 102.686 1.00 53.51  ? 713 VAL A C   1 
ATOM 4138 O O   . VAL A 1 713 ? 120.880 150.948 102.274 1.00 59.70  ? 713 VAL A O   1 
ATOM 4139 C CB  . VAL A 1 713 ? 122.993 151.405 104.664 1.00 51.21  ? 713 VAL A CB  1 
ATOM 4140 C CG1 . VAL A 1 713 ? 121.883 152.420 104.884 1.00 55.99  ? 713 VAL A CG1 1 
ATOM 4141 C CG2 . VAL A 1 713 ? 122.791 150.194 105.565 1.00 47.33  ? 713 VAL A CG2 1 
ATOM 4142 N N   . THR A 1 714 ? 121.864 148.959 102.659 1.00 56.27  ? 714 THR A N   1 
ATOM 4143 C CA  . THR A 1 714 ? 120.738 148.161 102.196 1.00 60.06  ? 714 THR A CA  1 
ATOM 4144 C C   . THR A 1 714 ? 120.174 147.365 103.363 1.00 48.89  ? 714 THR A C   1 
ATOM 4145 O O   . THR A 1 714 ? 120.876 146.538 103.951 1.00 52.15  ? 714 THR A O   1 
ATOM 4146 C CB  . THR A 1 714 ? 121.159 147.215 101.069 1.00 58.41  ? 714 THR A CB  1 
ATOM 4147 O OG1 . THR A 1 714 ? 121.602 147.978 99.940  1.00 60.97  ? 714 THR A OG1 1 
ATOM 4148 C CG2 . THR A 1 714 ? 119.991 146.342 100.646 1.00 50.17  ? 714 THR A CG2 1 
ATOM 4149 N N   . LEU A 1 715 ? 118.907 147.606 103.684 1.00 43.89  ? 715 LEU A N   1 
ATOM 4150 C CA  . LEU A 1 715 ? 118.220 146.905 104.759 1.00 53.74  ? 715 LEU A CA  1 
ATOM 4151 C C   . LEU A 1 715 ? 117.159 145.995 104.163 1.00 59.59  ? 715 LEU A C   1 
ATOM 4152 O O   . LEU A 1 715 ? 116.279 146.458 103.432 1.00 53.02  ? 715 LEU A O   1 
ATOM 4153 C CB  . LEU A 1 715 ? 117.586 147.893 105.741 1.00 57.80  ? 715 LEU A CB  1 
ATOM 4154 C CG  . LEU A 1 715 ? 116.470 147.378 106.651 1.00 50.38  ? 715 LEU A CG  1 
ATOM 4155 C CD1 . LEU A 1 715 ? 117.037 146.547 107.784 1.00 50.22  ? 715 LEU A CD1 1 
ATOM 4156 C CD2 . LEU A 1 715 ? 115.661 148.537 107.202 1.00 41.98  ? 715 LEU A CD2 1 
ATOM 4157 N N   . ARG A 1 716 ? 117.253 144.704 104.463 1.00 63.69  ? 716 ARG A N   1 
ATOM 4158 C CA  . ARG A 1 716 ? 116.263 143.723 104.048 1.00 62.29  ? 716 ARG A CA  1 
ATOM 4159 C C   . ARG A 1 716 ? 115.545 143.195 105.280 1.00 56.16  ? 716 ARG A C   1 
ATOM 4160 O O   . ARG A 1 716 ? 116.178 142.891 106.294 1.00 50.54  ? 716 ARG A O   1 
ATOM 4161 C CB  . ARG A 1 716 ? 116.909 142.568 103.268 1.00 62.55  ? 716 ARG A CB  1 
ATOM 4162 C CG  . ARG A 1 716 ? 115.949 141.437 102.930 1.00 60.04  ? 716 ARG A CG  1 
ATOM 4163 C CD  . ARG A 1 716 ? 116.023 141.034 101.470 1.00 58.67  ? 716 ARG A CD  1 
ATOM 4164 N NE  . ARG A 1 716 ? 115.086 139.958 101.168 1.00 65.06  ? 716 ARG A NE  1 
ATOM 4165 C CZ  . ARG A 1 716 ? 115.182 139.147 100.124 1.00 67.52  ? 716 ARG A CZ  1 
ATOM 4166 N NH1 . ARG A 1 716 ? 116.167 139.261 99.248  1.00 62.04  ? 716 ARG A NH1 1 
ATOM 4167 N NH2 . ARG A 1 716 ? 114.267 138.197 99.954  1.00 68.99  ? 716 ARG A NH2 1 
ATOM 4168 N N   . VAL A 1 717 ? 114.222 143.099 105.196 1.00 55.35  ? 717 VAL A N   1 
ATOM 4169 C CA  . VAL A 1 717 ? 113.398 142.647 106.307 1.00 58.54  ? 717 VAL A CA  1 
ATOM 4170 C C   . VAL A 1 717 ? 112.719 141.342 105.907 1.00 52.48  ? 717 VAL A C   1 
ATOM 4171 O O   . VAL A 1 717 ? 112.378 141.142 104.735 1.00 58.12  ? 717 VAL A O   1 
ATOM 4172 C CB  . VAL A 1 717 ? 112.384 143.730 106.738 1.00 54.31  ? 717 VAL A CB  1 
ATOM 4173 C CG1 . VAL A 1 717 ? 111.279 143.934 105.704 1.00 55.22  ? 717 VAL A CG1 1 
ATOM 4174 C CG2 . VAL A 1 717 ? 111.803 143.412 108.107 1.00 48.74  ? 717 VAL A CG2 1 
ATOM 4175 N N   . VAL A 1 718 ? 112.601 140.426 106.863 1.00 46.69  ? 718 VAL A N   1 
ATOM 4176 C CA  . VAL A 1 718 ? 111.880 139.180 106.666 1.00 53.74  ? 718 VAL A CA  1 
ATOM 4177 C C   . VAL A 1 718 ? 110.734 139.124 107.673 1.00 52.43  ? 718 VAL A C   1 
ATOM 4178 O O   . VAL A 1 718 ? 110.610 139.973 108.555 1.00 55.98  ? 718 VAL A O   1 
ATOM 4179 C CB  . VAL A 1 718 ? 112.800 137.949 106.783 1.00 51.52  ? 718 VAL A CB  1 
ATOM 4180 C CG1 . VAL A 1 718 ? 113.739 137.879 105.590 1.00 48.15  ? 718 VAL A CG1 1 
ATOM 4181 C CG2 . VAL A 1 718 ? 113.584 137.990 108.078 1.00 49.94  ? 718 VAL A CG2 1 
ATOM 4182 N N   . GLU A 1 719 ? 109.881 138.113 107.529 1.00 56.83  ? 719 GLU A N   1 
ATOM 4183 C CA  . GLU A 1 719 ? 108.646 138.052 108.296 1.00 57.17  ? 719 GLU A CA  1 
ATOM 4184 C C   . GLU A 1 719 ? 108.436 136.648 108.843 1.00 55.40  ? 719 GLU A C   1 
ATOM 4185 O O   . GLU A 1 719 ? 109.118 135.694 108.454 1.00 57.42  ? 719 GLU A O   1 
ATOM 4186 C CB  . GLU A 1 719 ? 107.446 138.483 107.443 1.00 57.38  ? 719 GLU A CB  1 
ATOM 4187 C CG  . GLU A 1 719 ? 107.258 137.659 106.182 1.00 61.14  ? 719 GLU A CG  1 
ATOM 4188 C CD  . GLU A 1 719 ? 107.944 138.272 104.975 1.00 60.89  ? 719 GLU A CD  1 
ATOM 4189 O OE1 . GLU A 1 719 ? 108.792 139.169 105.161 1.00 60.13  ? 719 GLU A OE1 1 
ATOM 4190 O OE2 . GLU A 1 719 ? 107.634 137.856 103.838 1.00 57.52  ? 719 GLU A OE2 1 
ATOM 4191 N N   . ASP A 1 720 ? 107.485 136.548 109.777 1.00 59.41  ? 720 ASP A N   1 
ATOM 4192 C CA  . ASP A 1 720 ? 107.031 135.300 110.396 1.00 63.92  ? 720 ASP A CA  1 
ATOM 4193 C C   . ASP A 1 720 ? 108.144 134.567 111.136 1.00 62.78  ? 720 ASP A C   1 
ATOM 4194 O O   . ASP A 1 720 ? 108.093 133.342 111.279 1.00 60.93  ? 720 ASP A O   1 
ATOM 4195 C CB  . ASP A 1 720 ? 106.381 134.365 109.366 1.00 63.89  ? 720 ASP A CB  1 
ATOM 4196 C CG  . ASP A 1 720 ? 104.943 134.738 109.062 1.00 61.41  ? 720 ASP A CG  1 
ATOM 4197 O OD1 . ASP A 1 720 ? 104.307 135.405 109.904 1.00 62.68  ? 720 ASP A OD1 1 
ATOM 4198 O OD2 . ASP A 1 720 ? 104.450 134.363 107.977 1.00 63.87  ? 720 ASP A OD2 1 
ATOM 4199 N N   . LEU A 1 721 ? 109.153 135.287 111.615 1.00 61.47  ? 721 LEU A N   1 
ATOM 4200 C CA  . LEU A 1 721 ? 110.285 134.688 112.302 1.00 62.55  ? 721 LEU A CA  1 
ATOM 4201 C C   . LEU A 1 721 ? 110.698 135.572 113.467 1.00 61.60  ? 721 LEU A C   1 
ATOM 4202 O O   . LEU A 1 721 ? 110.554 136.798 113.399 1.00 57.70  ? 721 LEU A O   1 
ATOM 4203 C CB  . LEU A 1 721 ? 111.479 134.496 111.352 1.00 60.95  ? 721 LEU A CB  1 
ATOM 4204 C CG  . LEU A 1 721 ? 111.337 133.393 110.306 1.00 57.51  ? 721 LEU A CG  1 
ATOM 4205 C CD1 . LEU A 1 721 ? 112.014 133.782 109.011 1.00 56.82  ? 721 LEU A CD1 1 
ATOM 4206 C CD2 . LEU A 1 721 ? 111.916 132.110 110.846 1.00 59.21  ? 721 LEU A CD2 1 
ATOM 4207 N N   . PRO A 1 722 ? 111.219 134.983 114.546 1.00 52.48  ? 722 PRO A N   1 
ATOM 4208 C CA  . PRO A 1 722 ? 111.748 135.802 115.641 1.00 48.92  ? 722 PRO A CA  1 
ATOM 4209 C C   . PRO A 1 722 ? 113.173 136.248 115.362 1.00 56.44  ? 722 PRO A C   1 
ATOM 4210 O O   . PRO A 1 722 ? 113.688 136.027 114.262 1.00 51.51  ? 722 PRO A O   1 
ATOM 4211 C CB  . PRO A 1 722 ? 111.678 134.858 116.844 1.00 40.78  ? 722 PRO A CB  1 
ATOM 4212 C CG  . PRO A 1 722 ? 111.852 133.508 116.255 1.00 40.16  ? 722 PRO A CG  1 
ATOM 4213 C CD  . PRO A 1 722 ? 111.302 133.544 114.849 1.00 46.84  ? 722 PRO A CD  1 
ATOM 4214 N N   . HIS A 1 723 ? 113.817 136.886 116.333 1.00 53.11  ? 723 HIS A N   1 
ATOM 4215 C CA  . HIS A 1 723 ? 115.242 137.165 116.248 1.00 49.01  ? 723 HIS A CA  1 
ATOM 4216 C C   . HIS A 1 723 ? 115.991 136.099 117.038 1.00 55.98  ? 723 HIS A C   1 
ATOM 4217 O O   . HIS A 1 723 ? 115.571 135.706 118.130 1.00 60.87  ? 723 HIS A O   1 
ATOM 4218 C CB  . HIS A 1 723 ? 115.557 138.593 116.731 1.00 49.35  ? 723 HIS A CB  1 
ATOM 4219 C CG  . HIS A 1 723 ? 115.894 138.719 118.187 1.00 57.05  ? 723 HIS A CG  1 
ATOM 4220 N ND1 . HIS A 1 723 ? 117.089 138.293 118.728 1.00 53.66  ? 723 HIS A ND1 1 
ATOM 4221 C CD2 . HIS A 1 723 ? 115.182 139.236 119.216 1.00 61.10  ? 723 HIS A CD2 1 
ATOM 4222 C CE1 . HIS A 1 723 ? 117.096 138.538 120.026 1.00 59.56  ? 723 HIS A CE1 1 
ATOM 4223 N NE2 . HIS A 1 723 ? 115.951 139.111 120.347 1.00 65.80  ? 723 HIS A NE2 1 
ATOM 4224 N N   . GLY A 1 724 ? 117.089 135.617 116.466 1.00 52.76  ? 724 GLY A N   1 
ATOM 4225 C CA  . GLY A 1 724 ? 117.803 134.492 117.030 1.00 56.18  ? 724 GLY A CA  1 
ATOM 4226 C C   . GLY A 1 724 ? 117.703 133.283 116.127 1.00 52.15  ? 724 GLY A C   1 
ATOM 4227 O O   . GLY A 1 724 ? 117.788 132.141 116.586 1.00 52.06  ? 724 GLY A O   1 
ATOM 4228 N N   . PHE A 1 725 ? 117.516 133.530 114.833 1.00 44.85  ? 725 PHE A N   1 
ATOM 4229 C CA  . PHE A 1 725 ? 117.337 132.475 113.847 1.00 41.90  ? 725 PHE A CA  1 
ATOM 4230 C C   . PHE A 1 725 ? 118.636 132.036 113.184 1.00 49.73  ? 725 PHE A C   1 
ATOM 4231 O O   . PHE A 1 725 ? 118.611 131.105 112.373 1.00 56.32  ? 725 PHE A O   1 
ATOM 4232 C CB  . PHE A 1 725 ? 116.345 132.925 112.766 1.00 35.62  ? 725 PHE A CB  1 
ATOM 4233 C CG  . PHE A 1 725 ? 116.829 134.081 111.937 1.00 31.32  ? 725 PHE A CG  1 
ATOM 4234 C CD1 . PHE A 1 725 ? 116.668 135.383 112.378 1.00 34.94  ? 725 PHE A CD1 1 
ATOM 4235 C CD2 . PHE A 1 725 ? 117.429 133.870 110.707 1.00 33.22  ? 725 PHE A CD2 1 
ATOM 4236 C CE1 . PHE A 1 725 ? 117.112 136.445 111.618 1.00 38.52  ? 725 PHE A CE1 1 
ATOM 4237 C CE2 . PHE A 1 725 ? 117.876 134.934 109.951 1.00 44.94  ? 725 PHE A CE2 1 
ATOM 4238 C CZ  . PHE A 1 725 ? 117.712 136.220 110.404 1.00 43.86  ? 725 PHE A CZ  1 
ATOM 4239 N N   . LEU A 1 726 ? 119.759 132.689 113.483 1.00 48.51  ? 726 LEU A N   1 
ATOM 4240 C CA  . LEU A 1 726 ? 121.016 132.303 112.851 1.00 41.76  ? 726 LEU A CA  1 
ATOM 4241 C C   . LEU A 1 726 ? 121.559 131.012 113.448 1.00 46.56  ? 726 LEU A C   1 
ATOM 4242 O O   . LEU A 1 726 ? 122.114 130.175 112.728 1.00 46.78  ? 726 LEU A O   1 
ATOM 4243 C CB  . LEU A 1 726 ? 122.032 133.436 112.972 1.00 45.92  ? 726 LEU A CB  1 
ATOM 4244 C CG  . LEU A 1 726 ? 122.009 134.396 111.782 1.00 44.54  ? 726 LEU A CG  1 
ATOM 4245 C CD1 . LEU A 1 726 ? 123.083 135.452 111.907 1.00 44.29  ? 726 LEU A CD1 1 
ATOM 4246 C CD2 . LEU A 1 726 ? 122.177 133.622 110.486 1.00 44.62  ? 726 LEU A CD2 1 
ATOM 4247 N N   . THR A 1 727 ? 121.386 130.821 114.755 1.00 57.38  ? 727 THR A N   1 
ATOM 4248 C CA  . THR A 1 727 ? 121.742 129.579 115.425 1.00 66.33  ? 727 THR A CA  1 
ATOM 4249 C C   . THR A 1 727 ? 120.632 128.538 115.339 1.00 65.80  ? 727 THR A C   1 
ATOM 4250 O O   . THR A 1 727 ? 120.596 127.609 116.153 1.00 69.48  ? 727 THR A O   1 
ATOM 4251 C CB  . THR A 1 727 ? 122.090 129.851 116.890 1.00 63.61  ? 727 THR A CB  1 
ATOM 4252 O OG1 . THR A 1 727 ? 120.890 129.859 117.672 1.00 65.77  ? 727 THR A OG1 1 
ATOM 4253 C CG2 . THR A 1 727 ? 122.783 131.195 117.032 1.00 56.74  ? 727 THR A CG2 1 
ATOM 4254 N N   . LEU A 1 728 ? 119.722 128.686 114.375 1.00 41.86  ? 728 LEU A N   1 
ATOM 4255 C CA  . LEU A 1 728 ? 118.517 127.873 114.281 1.00 34.67  ? 728 LEU A CA  1 
ATOM 4256 C C   . LEU A 1 728 ? 118.210 127.530 112.822 1.00 40.54  ? 728 LEU A C   1 
ATOM 4257 O O   . LEU A 1 728 ? 117.051 127.313 112.458 1.00 47.23  ? 728 LEU A O   1 
ATOM 4258 C CB  . LEU A 1 728 ? 117.377 128.625 114.985 1.00 43.00  ? 728 LEU A CB  1 
ATOM 4259 C CG  . LEU A 1 728 ? 115.907 128.284 115.220 1.00 48.80  ? 728 LEU A CG  1 
ATOM 4260 C CD1 . LEU A 1 728 ? 115.574 128.633 116.645 1.00 46.39  ? 728 LEU A CD1 1 
ATOM 4261 C CD2 . LEU A 1 728 ? 115.041 129.102 114.295 1.00 37.58  ? 728 LEU A CD2 1 
ATOM 4262 N N   . ALA A 1 729 ? 119.243 127.470 111.976 1.00 51.50  ? 729 ALA A N   1 
ATOM 4263 C CA  . ALA A 1 729 ? 119.044 127.253 110.545 1.00 56.38  ? 729 ALA A CA  1 
ATOM 4264 C C   . ALA A 1 729 ? 118.530 125.854 110.234 1.00 58.19  ? 729 ALA A C   1 
ATOM 4265 O O   . ALA A 1 729 ? 117.681 125.692 109.350 1.00 55.88  ? 729 ALA A O   1 
ATOM 4266 C CB  . ALA A 1 729 ? 120.349 127.503 109.792 1.00 54.88  ? 729 ALA A CB  1 
ATOM 4267 N N   . ALA A 1 730 ? 119.030 124.839 110.930 1.00 52.35  ? 730 ALA A N   1 
ATOM 4268 C CA  . ALA A 1 730 ? 118.652 123.453 110.654 1.00 46.35  ? 730 ALA A CA  1 
ATOM 4269 C C   . ALA A 1 730 ? 117.437 123.026 111.469 1.00 50.06  ? 730 ALA A C   1 
ATOM 4270 O O   . ALA A 1 730 ? 117.455 122.012 112.165 1.00 57.25  ? 730 ALA A O   1 
ATOM 4271 C CB  . ALA A 1 730 ? 119.837 122.532 110.915 1.00 52.63  ? 730 ALA A CB  1 
ATOM 4272 N N   . LEU A 1 731 ? 116.373 123.806 111.393 1.00 46.05  ? 731 LEU A N   1 
ATOM 4273 C CA  . LEU A 1 731 ? 115.165 123.500 112.148 1.00 46.22  ? 731 LEU A CA  1 
ATOM 4274 C C   . LEU A 1 731 ? 113.902 123.536 111.303 1.00 49.45  ? 731 LEU A C   1 
ATOM 4275 O O   . LEU A 1 731 ? 112.999 122.726 111.525 1.00 59.36  ? 731 LEU A O   1 
ATOM 4276 C CB  . LEU A 1 731 ? 115.042 124.474 113.317 1.00 46.05  ? 731 LEU A CB  1 
ATOM 4277 C CG  . LEU A 1 731 ? 113.933 124.197 114.321 1.00 49.39  ? 731 LEU A CG  1 
ATOM 4278 C CD1 . LEU A 1 731 ? 114.554 124.122 115.690 1.00 50.06  ? 731 LEU A CD1 1 
ATOM 4279 C CD2 . LEU A 1 731 ? 112.868 125.275 114.266 1.00 44.91  ? 731 LEU A CD2 1 
ATOM 4280 N N   . CYS A 1 732 ? 113.814 124.449 110.340 1.00 47.91  ? 732 CYS A N   1 
ATOM 4281 C CA  . CYS A 1 732 ? 112.612 124.596 109.533 1.00 47.11  ? 732 CYS A CA  1 
ATOM 4282 C C   . CYS A 1 732 ? 113.006 125.087 108.148 1.00 51.98  ? 732 CYS A C   1 
ATOM 4283 O O   . CYS A 1 732 ? 114.171 125.385 107.880 1.00 60.86  ? 732 CYS A O   1 
ATOM 4284 C CB  . CYS A 1 732 ? 111.615 125.551 110.195 1.00 52.31  ? 732 CYS A CB  1 
ATOM 4285 S SG  . CYS A 1 732 ? 110.480 126.369 109.056 1.00 72.41  ? 732 CYS A SG  1 
ATOM 4286 N N   . ARG A 1 733 ? 112.016 125.150 107.257 1.00 52.78  ? 733 ARG A N   1 
ATOM 4287 C CA  . ARG A 1 733 ? 112.279 125.619 105.901 1.00 51.71  ? 733 ARG A CA  1 
ATOM 4288 C C   . ARG A 1 733 ? 112.374 127.140 105.850 1.00 60.77  ? 733 ARG A C   1 
ATOM 4289 O O   . ARG A 1 733 ? 113.206 127.691 105.120 1.00 65.85  ? 733 ARG A O   1 
ATOM 4290 C CB  . ARG A 1 733 ? 111.197 125.097 104.948 1.00 59.18  ? 733 ARG A CB  1 
ATOM 4291 C CG  . ARG A 1 733 ? 111.205 125.596 103.474 1.00 59.98  ? 733 ARG A CG  1 
ATOM 4292 C CD  . ARG A 1 733 ? 112.569 125.728 102.745 1.00 60.76  ? 733 ARG A CD  1 
ATOM 4293 N NE  . ARG A 1 733 ? 113.606 124.789 103.164 1.00 59.20  ? 733 ARG A NE  1 
ATOM 4294 C CZ  . ARG A 1 733 ? 114.833 124.760 102.662 1.00 65.72  ? 733 ARG A CZ  1 
ATOM 4295 N NH1 . ARG A 1 733 ? 115.219 125.616 101.730 1.00 67.62  ? 733 ARG A NH1 1 
ATOM 4296 N NH2 . ARG A 1 733 ? 115.698 123.857 103.115 1.00 61.05  ? 733 ARG A NH2 1 
ATOM 4297 N N   . GLU A 1 734 ? 111.544 127.843 106.620 1.00 60.77  ? 734 GLU A N   1 
ATOM 4298 C CA  . GLU A 1 734 ? 111.619 129.298 106.606 1.00 59.66  ? 734 GLU A CA  1 
ATOM 4299 C C   . GLU A 1 734 ? 112.815 129.835 107.382 1.00 61.42  ? 734 GLU A C   1 
ATOM 4300 O O   . GLU A 1 734 ? 113.330 130.901 107.033 1.00 57.39  ? 734 GLU A O   1 
ATOM 4301 C CB  . GLU A 1 734 ? 110.326 129.909 107.144 1.00 53.61  ? 734 GLU A CB  1 
ATOM 4302 C CG  . GLU A 1 734 ? 109.085 129.443 106.409 1.00 57.45  ? 734 GLU A CG  1 
ATOM 4303 C CD  . GLU A 1 734 ? 108.009 130.505 106.364 1.00 65.07  ? 734 GLU A CD  1 
ATOM 4304 O OE1 . GLU A 1 734 ? 107.584 130.874 105.249 1.00 59.42  ? 734 GLU A OE1 1 
ATOM 4305 O OE2 . GLU A 1 734 ? 107.604 130.989 107.437 1.00 68.65  ? 734 GLU A OE2 1 
ATOM 4306 N N   . THR A 1 735 ? 113.271 129.127 108.419 1.00 55.81  ? 735 THR A N   1 
ATOM 4307 C CA  . THR A 1 735 ? 114.517 129.510 109.072 1.00 52.19  ? 735 THR A CA  1 
ATOM 4308 C C   . THR A 1 735 ? 115.725 129.173 108.212 1.00 43.33  ? 735 THR A C   1 
ATOM 4309 O O   . THR A 1 735 ? 116.791 129.767 108.402 1.00 45.75  ? 735 THR A O   1 
ATOM 4310 C CB  . THR A 1 735 ? 114.654 128.822 110.428 1.00 49.14  ? 735 THR A CB  1 
ATOM 4311 O OG1 . THR A 1 735 ? 115.163 127.499 110.238 1.00 59.00  ? 735 THR A OG1 1 
ATOM 4312 C CG2 . THR A 1 735 ? 113.304 128.723 111.099 1.00 45.58  ? 735 THR A CG2 1 
ATOM 4313 N N   . ARG A 1 736 ? 115.586 128.215 107.294 1.00 50.56  ? 736 ARG A N   1 
ATOM 4314 C CA  . ARG A 1 736 ? 116.650 127.936 106.338 1.00 49.89  ? 736 ARG A CA  1 
ATOM 4315 C C   . ARG A 1 736 ? 116.883 129.127 105.423 1.00 51.16  ? 736 ARG A C   1 
ATOM 4316 O O   . ARG A 1 736 ? 118.008 129.616 105.299 0.17 55.27  ? 736 ARG A O   1 
ATOM 4317 C CB  . ARG A 1 736 ? 116.299 126.704 105.506 1.00 60.05  ? 736 ARG A CB  1 
ATOM 4318 C CG  . ARG A 1 736 ? 117.489 125.929 104.976 1.00 54.11  ? 736 ARG A CG  1 
ATOM 4319 C CD  . ARG A 1 736 ? 118.018 124.949 105.998 1.00 53.72  ? 736 ARG A CD  1 
ATOM 4320 N NE  . ARG A 1 736 ? 116.956 124.067 106.468 1.00 51.17  ? 736 ARG A NE  1 
ATOM 4321 C CZ  . ARG A 1 736 ? 117.152 122.968 107.181 1.00 55.46  ? 736 ARG A CZ  1 
ATOM 4322 N NH1 . ARG A 1 736 ? 118.370 122.538 107.464 1.00 53.86  ? 736 ARG A NH1 1 
ATOM 4323 N NH2 . ARG A 1 736 ? 116.101 122.270 107.601 1.00 55.19  ? 736 ARG A NH2 1 
ATOM 4324 N N   . GLN A 1 737 ? 115.820 129.625 104.791 1.00 51.35  ? 737 GLN A N   1 
ATOM 4325 C CA  . GLN A 1 737 ? 115.951 130.698 103.814 1.00 60.33  ? 737 GLN A CA  1 
ATOM 4326 C C   . GLN A 1 737 ? 116.223 132.053 104.449 1.00 62.23  ? 737 GLN A C   1 
ATOM 4327 O O   . GLN A 1 737 ? 116.563 132.998 103.728 1.00 58.80  ? 737 GLN A O   1 
ATOM 4328 C CB  . GLN A 1 737 ? 114.690 130.779 102.947 1.00 57.37  ? 737 GLN A CB  1 
ATOM 4329 C CG  . GLN A 1 737 ? 114.432 129.554 102.070 1.00 56.12  ? 737 GLN A CG  1 
ATOM 4330 C CD  . GLN A 1 737 ? 115.340 129.479 100.850 1.00 56.02  ? 737 GLN A CD  1 
ATOM 4331 O OE1 . GLN A 1 737 ? 116.551 129.285 100.964 1.00 50.74  ? 737 GLN A OE1 1 
ATOM 4332 N NE2 . GLN A 1 737 ? 114.750 129.632 99.670  1.00 59.59  ? 737 GLN A NE2 1 
ATOM 4333 N N   . ALA A 1 738 ? 116.079 132.175 105.767 1.00 57.97  ? 738 ALA A N   1 
ATOM 4334 C CA  . ALA A 1 738 ? 116.410 133.412 106.459 1.00 55.12  ? 738 ALA A CA  1 
ATOM 4335 C C   . ALA A 1 738 ? 117.845 133.419 106.969 1.00 51.70  ? 738 ALA A C   1 
ATOM 4336 O O   . ALA A 1 738 ? 118.526 134.446 106.884 1.00 53.08  ? 738 ALA A O   1 
ATOM 4337 C CB  . ALA A 1 738 ? 115.443 133.639 107.621 1.00 55.00  ? 738 ALA A CB  1 
ATOM 4338 N N   . ALA A 1 739 ? 118.319 132.298 107.516 1.00 51.54  ? 739 ALA A N   1 
ATOM 4339 C CA  . ALA A 1 739 ? 119.701 132.235 107.978 1.00 52.15  ? 739 ALA A CA  1 
ATOM 4340 C C   . ALA A 1 739 ? 120.677 132.121 106.814 1.00 52.04  ? 739 ALA A C   1 
ATOM 4341 O O   . ALA A 1 739 ? 121.841 132.513 106.945 1.00 60.46  ? 739 ALA A O   1 
ATOM 4342 C CB  . ALA A 1 739 ? 119.883 131.068 108.945 1.00 54.51  ? 739 ALA A CB  1 
ATOM 4343 N N   . GLU A 1 740 ? 120.230 131.582 105.681 1.00 43.84  ? 740 GLU A N   1 
ATOM 4344 C CA  . GLU A 1 740 ? 121.024 131.592 104.460 1.00 42.40  ? 740 GLU A CA  1 
ATOM 4345 C C   . GLU A 1 740 ? 121.048 132.970 103.806 1.00 47.98  ? 740 GLU A C   1 
ATOM 4346 O O   . GLU A 1 740 ? 121.979 133.265 103.046 1.00 51.73  ? 740 GLU A O   1 
ATOM 4347 C CB  . GLU A 1 740 ? 120.488 130.501 103.513 1.00 53.82  ? 740 GLU A CB  1 
ATOM 4348 C CG  . GLU A 1 740 ? 120.560 130.728 102.008 1.00 53.83  ? 740 GLU A CG  1 
ATOM 4349 C CD  . GLU A 1 740 ? 119.712 129.738 101.231 1.00 58.27  ? 740 GLU A CD  1 
ATOM 4350 O OE1 . GLU A 1 740 ? 119.258 130.085 100.120 1.00 54.84  ? 740 GLU A OE1 1 
ATOM 4351 O OE2 . GLU A 1 740 ? 119.498 128.613 101.732 1.00 61.08  ? 740 GLU A OE2 1 
ATOM 4352 N N   . LEU A 1 741 ? 120.095 133.845 104.152 1.00 55.30  ? 741 LEU A N   1 
ATOM 4353 C CA  . LEU A 1 741 ? 120.078 135.204 103.612 1.00 63.11  ? 741 LEU A CA  1 
ATOM 4354 C C   . LEU A 1 741 ? 121.301 136.010 104.036 1.00 65.90  ? 741 LEU A C   1 
ATOM 4355 O O   . LEU A 1 741 ? 121.677 136.969 103.353 1.00 67.19  ? 741 LEU A O   1 
ATOM 4356 C CB  . LEU A 1 741 ? 118.802 135.929 104.040 1.00 61.94  ? 741 LEU A CB  1 
ATOM 4357 C CG  . LEU A 1 741 ? 118.278 137.044 103.132 1.00 61.70  ? 741 LEU A CG  1 
ATOM 4358 C CD1 . LEU A 1 741 ? 118.367 136.655 101.663 1.00 60.61  ? 741 LEU A CD1 1 
ATOM 4359 C CD2 . LEU A 1 741 ? 116.851 137.407 103.512 1.00 61.90  ? 741 LEU A CD2 1 
ATOM 4360 N N   . CYS A 1 742 ? 121.929 135.646 105.156 1.00 63.51  ? 742 CYS A N   1 
ATOM 4361 C CA  . CYS A 1 742 ? 123.183 136.281 105.544 1.00 56.65  ? 742 CYS A CA  1 
ATOM 4362 C C   . CYS A 1 742 ? 124.321 135.920 104.595 1.00 51.71  ? 742 CYS A C   1 
ATOM 4363 O O   . CYS A 1 742 ? 125.236 136.725 104.398 1.00 53.34  ? 742 CYS A O   1 
ATOM 4364 C CB  . CYS A 1 742 ? 123.548 135.884 106.973 1.00 48.19  ? 742 CYS A CB  1 
ATOM 4365 S SG  . CYS A 1 742 ? 122.411 136.493 108.230 1.00 60.23  ? 742 CYS A SG  1 
ATOM 4366 N N   . VAL A 1 743 ? 124.281 134.723 104.003 1.00 53.73  ? 743 VAL A N   1 
ATOM 4367 C CA  . VAL A 1 743 ? 125.431 134.213 103.261 1.00 49.85  ? 743 VAL A CA  1 
ATOM 4368 C C   . VAL A 1 743 ? 125.625 134.959 101.945 1.00 55.27  ? 743 VAL A C   1 
ATOM 4369 O O   . VAL A 1 743 ? 126.748 135.349 101.608 1.00 59.28  ? 743 VAL A O   1 
ATOM 4370 C CB  . VAL A 1 743 ? 125.292 132.698 103.031 1.00 52.58  ? 743 VAL A CB  1 
ATOM 4371 C CG1 . VAL A 1 743 ? 126.621 132.110 102.603 1.00 47.97  ? 743 VAL A CG1 1 
ATOM 4372 C CG2 . VAL A 1 743 ? 124.796 132.015 104.288 1.00 53.77  ? 743 VAL A CG2 1 
ATOM 4373 N N   . GLU A 1 744 ? 124.555 135.159 101.168 1.00 54.04  ? 744 GLU A N   1 
ATOM 4374 C CA  . GLU A 1 744 ? 124.754 135.725 99.834  1.00 59.84  ? 744 GLU A CA  1 
ATOM 4375 C C   . GLU A 1 744 ? 125.042 137.219 99.879  1.00 60.04  ? 744 GLU A C   1 
ATOM 4376 O O   . GLU A 1 744 ? 125.576 137.770 98.910  1.00 64.48  ? 744 GLU A O   1 
ATOM 4377 C CB  . GLU A 1 744 ? 123.550 135.467 98.920  1.00 58.61  ? 744 GLU A CB  1 
ATOM 4378 C CG  . GLU A 1 744 ? 123.708 135.881 97.468  1.00 59.22  ? 744 GLU A CG  1 
ATOM 4379 C CD  . GLU A 1 744 ? 122.481 136.585 96.935  1.00 66.91  ? 744 GLU A CD  1 
ATOM 4380 O OE1 . GLU A 1 744 ? 122.534 137.815 96.732  1.00 66.00  ? 744 GLU A OE1 1 
ATOM 4381 O OE2 . GLU A 1 744 ? 121.452 135.906 96.754  1.00 66.24  ? 744 GLU A OE2 1 
ATOM 4382 N N   . ARG A 1 745 ? 124.701 137.889 100.974 1.00 56.52  ? 745 ARG A N   1 
ATOM 4383 C CA  . ARG A 1 745 ? 125.056 139.290 101.129 1.00 63.57  ? 745 ARG A CA  1 
ATOM 4384 C C   . ARG A 1 745 ? 126.413 139.487 101.790 1.00 64.48  ? 745 ARG A C   1 
ATOM 4385 O O   . ARG A 1 745 ? 126.929 140.610 101.783 1.00 67.15  ? 745 ARG A O   1 
ATOM 4386 C CB  . ARG A 1 745 ? 123.978 140.022 101.932 1.00 55.80  ? 745 ARG A CB  1 
ATOM 4387 C CG  . ARG A 1 745 ? 122.563 139.650 101.528 1.00 54.02  ? 745 ARG A CG  1 
ATOM 4388 C CD  . ARG A 1 745 ? 121.544 140.337 102.413 1.00 56.06  ? 745 ARG A CD  1 
ATOM 4389 N NE  . ARG A 1 745 ? 121.875 141.743 102.606 1.00 60.33  ? 745 ARG A NE  1 
ATOM 4390 C CZ  . ARG A 1 745 ? 121.620 142.702 101.727 1.00 61.30  ? 745 ARG A CZ  1 
ATOM 4391 N NH1 . ARG A 1 745 ? 121.014 142.447 100.579 1.00 59.86  ? 745 ARG A NH1 1 
ATOM 4392 N NH2 . ARG A 1 745 ? 121.985 143.950 102.006 1.00 56.23  ? 745 ARG A NH2 1 
ATOM 4393 N N   . ILE A 1 746 ? 127.005 138.431 102.351 1.00 47.64  ? 746 ILE A N   1 
ATOM 4394 C CA  . ILE A 1 746 ? 128.331 138.546 102.947 1.00 38.35  ? 746 ILE A CA  1 
ATOM 4395 C C   . ILE A 1 746 ? 129.435 138.393 101.907 1.00 37.65  ? 746 ILE A C   1 
ATOM 4396 O O   . ILE A 1 746 ? 130.581 138.780 102.173 1.00 53.06  ? 746 ILE A O   1 
ATOM 4397 C CB  . ILE A 1 746 ? 128.503 137.525 104.090 1.00 37.52  ? 746 ILE A CB  1 
ATOM 4398 C CG1 . ILE A 1 746 ? 129.367 138.096 105.208 1.00 32.14  ? 746 ILE A CG1 1 
ATOM 4399 C CG2 . ILE A 1 746 ? 129.132 136.235 103.612 1.00 45.38  ? 746 ILE A CG2 1 
ATOM 4400 C CD1 . ILE A 1 746 ? 129.307 137.279 106.472 1.00 25.23  ? 746 ILE A CD1 1 
ATOM 4401 N N   . ARG A 1 747 ? 129.122 137.862 100.727 1.00 40.67  ? 747 ARG A N   1 
ATOM 4402 C CA  . ARG A 1 747 ? 130.108 137.677 99.673  1.00 50.58  ? 747 ARG A CA  1 
ATOM 4403 C C   . ARG A 1 747 ? 130.160 138.843 98.694  1.00 50.99  ? 747 ARG A C   1 
ATOM 4404 O O   . ARG A 1 747 ? 131.015 138.845 97.803  1.00 53.61  ? 747 ARG A O   1 
ATOM 4405 C CB  . ARG A 1 747 ? 129.836 136.373 98.915  1.00 51.71  ? 747 ARG A CB  1 
ATOM 4406 C CG  . ARG A 1 747 ? 128.660 136.428 97.958  1.00 49.85  ? 747 ARG A CG  1 
ATOM 4407 C CD  . ARG A 1 747 ? 128.638 135.194 97.080  1.00 52.40  ? 747 ARG A CD  1 
ATOM 4408 N NE  . ARG A 1 747 ? 128.507 133.980 97.875  1.00 48.74  ? 747 ARG A NE  1 
ATOM 4409 C CZ  . ARG A 1 747 ? 127.367 133.329 98.059  1.00 52.90  ? 747 ARG A CZ  1 
ATOM 4410 N NH1 . ARG A 1 747 ? 126.241 133.735 97.496  1.00 51.28  ? 747 ARG A NH1 1 
ATOM 4411 N NH2 . ARG A 1 747 ? 127.357 132.243 98.826  1.00 55.25  ? 747 ARG A NH2 1 
ATOM 4412 N N   . LEU A 1 748 ? 129.270 139.827 98.830  1.00 48.10  ? 748 LEU A N   1 
ATOM 4413 C CA  . LEU A 1 748 ? 129.375 141.051 98.044  1.00 56.01  ? 748 LEU A CA  1 
ATOM 4414 C C   . LEU A 1 748 ? 130.520 141.938 98.508  1.00 60.68  ? 748 LEU A C   1 
ATOM 4415 O O   . LEU A 1 748 ? 131.004 142.762 97.725  1.00 61.11  ? 748 LEU A O   1 
ATOM 4416 C CB  . LEU A 1 748 ? 128.062 141.836 98.096  1.00 55.05  ? 748 LEU A CB  1 
ATOM 4417 C CG  . LEU A 1 748 ? 127.086 141.673 96.926  1.00 57.90  ? 748 LEU A CG  1 
ATOM 4418 C CD1 . LEU A 1 748 ? 127.592 142.433 95.708  1.00 57.18  ? 748 LEU A CD1 1 
ATOM 4419 C CD2 . LEU A 1 748 ? 126.833 140.211 96.584  1.00 58.25  ? 748 LEU A CD2 1 
ATOM 4420 N N   . VAL A 1 749 ? 130.948 141.790 99.764  1.00 50.98  ? 749 VAL A N   1 
ATOM 4421 C CA  . VAL A 1 749 ? 132.178 142.407 100.244 1.00 48.41  ? 749 VAL A CA  1 
ATOM 4422 C C   . VAL A 1 749 ? 133.407 141.889 99.507  1.00 48.68  ? 749 VAL A C   1 
ATOM 4423 O O   . VAL A 1 749 ? 134.358 142.650 99.282  1.00 47.58  ? 749 VAL A O   1 
ATOM 4424 C CB  . VAL A 1 749 ? 132.330 142.152 101.753 1.00 42.59  ? 749 VAL A CB  1 
ATOM 4425 C CG1 . VAL A 1 749 ? 133.421 143.020 102.343 1.00 46.95  ? 749 VAL A CG1 1 
ATOM 4426 C CG2 . VAL A 1 749 ? 131.008 142.386 102.468 1.00 33.18  ? 749 VAL A CG2 1 
ATOM 4427 N N   . LEU A 1 750 ? 133.394 140.618 99.101  1.00 50.85  ? 750 LEU A N   1 
ATOM 4428 C CA  . LEU A 1 750 ? 134.611 139.937 98.679  1.00 51.98  ? 750 LEU A CA  1 
ATOM 4429 C C   . LEU A 1 750 ? 135.088 140.393 97.305  1.00 53.42  ? 750 LEU A C   1 
ATOM 4430 O O   . LEU A 1 750 ? 136.236 140.130 96.936  1.00 55.03  ? 750 LEU A O   1 
ATOM 4431 C CB  . LEU A 1 750 ? 134.380 138.425 98.687  1.00 43.55  ? 750 LEU A CB  1 
ATOM 4432 C CG  . LEU A 1 750 ? 134.639 137.616 99.967  1.00 44.89  ? 750 LEU A CG  1 
ATOM 4433 C CD1 . LEU A 1 750 ? 136.115 137.616 100.301 1.00 52.48  ? 750 LEU A CD1 1 
ATOM 4434 C CD2 . LEU A 1 750 ? 133.817 138.077 101.166 1.00 34.88  ? 750 LEU A CD2 1 
ATOM 4435 N N   . THR A 1 751 ? 134.236 141.042 96.526  1.00 66.46  ? 751 THR A N   1 
ATOM 4436 C CA  . THR A 1 751 ? 134.654 141.474 95.194  1.00 68.10  ? 751 THR A CA  1 
ATOM 4437 C C   . THR A 1 751 ? 135.247 142.880 95.254  1.00 64.69  ? 751 THR A C   1 
ATOM 4438 O O   . THR A 1 751 ? 134.663 143.763 95.888  1.00 69.57  ? 751 THR A O   1 
ATOM 4439 C CB  . THR A 1 751 ? 133.480 141.435 94.215  1.00 68.39  ? 751 THR A CB  1 
ATOM 4440 O OG1 . THR A 1 751 ? 132.333 142.062 94.803  1.00 72.76  ? 751 THR A OG1 1 
ATOM 4441 C CG2 . THR A 1 751 ? 133.144 139.997 93.839  1.00 72.14  ? 751 THR A CG2 1 
ATOM 4442 N N   . PRO A 1 752 ? 136.416 143.118 94.630  1.00 82.13  ? 752 PRO A N   1 
ATOM 4443 C CA  . PRO A 1 752 ? 137.156 144.386 94.489  1.00 85.87  ? 752 PRO A CA  1 
ATOM 4444 C C   . PRO A 1 752 ? 136.402 145.483 93.748  1.00 86.15  ? 752 PRO A C   1 
ATOM 4445 O O   . PRO A 1 752 ? 136.745 145.775 92.604  1.00 86.80  ? 752 PRO A O   1 
ATOM 4446 C CB  . PRO A 1 752 ? 138.363 143.878 93.695  1.00 87.70  ? 752 PRO A CB  1 
ATOM 4447 C CG  . PRO A 1 752 ? 138.399 142.544 94.374  1.00 85.53  ? 752 PRO A CG  1 
ATOM 4448 C CD  . PRO A 1 752 ? 137.115 142.208 93.791  1.00 81.47  ? 752 PRO A CD  1 
ATOM 4449 N N   . ARG B 1 4   ? 147.029 88.190  105.754 1.00 94.38  ? 4   ARG B N   1 
ATOM 4450 C CA  . ARG B 1 4   ? 148.403 88.172  106.242 1.00 98.14  ? 4   ARG B CA  1 
ATOM 4451 C C   . ARG B 1 4   ? 149.065 89.534  106.065 1.00 96.31  ? 4   ARG B C   1 
ATOM 4452 O O   . ARG B 1 4   ? 149.794 89.993  106.943 1.00 94.84  ? 4   ARG B O   1 
ATOM 4453 C CB  . ARG B 1 4   ? 149.215 87.092  105.521 1.00 96.00  ? 4   ARG B CB  1 
ATOM 4454 C CG  . ARG B 1 4   ? 150.646 86.934  106.021 1.00 94.54  ? 4   ARG B CG  1 
ATOM 4455 C CD  . ARG B 1 4   ? 150.702 86.766  107.534 1.00 94.18  ? 4   ARG B CD  1 
ATOM 4456 N NE  . ARG B 1 4   ? 152.010 87.119  108.074 1.00 94.20  ? 4   ARG B NE  1 
ATOM 4457 C CZ  . ARG B 1 4   ? 152.286 87.215  109.367 1.00 92.26  ? 4   ARG B CZ  1 
ATOM 4458 N NH1 . ARG B 1 4   ? 151.363 87.001  110.289 1.00 93.21  ? 4   ARG B NH1 1 
ATOM 4459 N NH2 . ARG B 1 4   ? 153.521 87.533  109.745 1.00 94.25  ? 4   ARG B NH2 1 
ATOM 4460 N N   . THR B 1 5   ? 148.802 90.178  104.924 1.00 103.32 ? 5   THR B N   1 
ATOM 4461 C CA  . THR B 1 5   ? 149.416 91.473  104.646 1.00 103.16 ? 5   THR B CA  1 
ATOM 4462 C C   . THR B 1 5   ? 148.864 92.572  105.546 1.00 107.13 ? 5   THR B C   1 
ATOM 4463 O O   . THR B 1 5   ? 149.546 93.575  105.782 1.00 108.11 ? 5   THR B O   1 
ATOM 4464 C CB  . THR B 1 5   ? 149.231 91.843  103.171 1.00 105.77 ? 5   THR B CB  1 
ATOM 4465 O OG1 . THR B 1 5   ? 149.787 93.142  102.927 1.00 103.58 ? 5   THR B OG1 1 
ATOM 4466 C CG2 . THR B 1 5   ? 147.758 91.837  102.779 1.00 105.53 ? 5   THR B CG2 1 
ATOM 4467 N N   . MET B 1 6   ? 147.641 92.408  106.054 1.00 97.36  ? 6   MET B N   1 
ATOM 4468 C CA  . MET B 1 6   ? 147.100 93.383  106.995 1.00 95.98  ? 6   MET B CA  1 
ATOM 4469 C C   . MET B 1 6   ? 147.699 93.210  108.384 1.00 93.73  ? 6   MET B C   1 
ATOM 4470 O O   . MET B 1 6   ? 147.769 94.175  109.153 1.00 90.98  ? 6   MET B O   1 
ATOM 4471 C CB  . MET B 1 6   ? 145.577 93.269  107.050 1.00 98.82  ? 6   MET B CB  1 
ATOM 4472 C CG  . MET B 1 6   ? 144.875 93.710  105.776 1.00 96.51  ? 6   MET B CG  1 
ATOM 4473 S SD  . MET B 1 6   ? 144.590 95.489  105.720 1.00 100.93 ? 6   MET B SD  1 
ATOM 4474 C CE  . MET B 1 6   ? 143.089 95.621  106.688 1.00 95.58  ? 6   MET B CE  1 
ATOM 4475 N N   . THR B 1 7   ? 148.131 91.996  108.722 1.00 95.54  ? 7   THR B N   1 
ATOM 4476 C CA  . THR B 1 7   ? 148.733 91.724  110.022 1.00 101.32 ? 7   THR B CA  1 
ATOM 4477 C C   . THR B 1 7   ? 150.245 91.913  110.008 1.00 102.93 ? 7   THR B C   1 
ATOM 4478 O O   . THR B 1 7   ? 150.814 92.385  110.998 1.00 103.11 ? 7   THR B O   1 
ATOM 4479 C CB  . THR B 1 7   ? 148.392 90.302  110.474 1.00 99.25  ? 7   THR B CB  1 
ATOM 4480 O OG1 . THR B 1 7   ? 148.925 89.359  109.537 1.00 97.82  ? 7   THR B OG1 1 
ATOM 4481 C CG2 . THR B 1 7   ? 146.885 90.117  110.564 1.00 97.15  ? 7   THR B CG2 1 
ATOM 4482 N N   . GLN B 1 8   ? 150.904 91.545  108.905 1.00 93.87  ? 8   GLN B N   1 
ATOM 4483 C CA  . GLN B 1 8   ? 152.347 91.741  108.785 1.00 90.47  ? 8   GLN B CA  1 
ATOM 4484 C C   . GLN B 1 8   ? 152.714 93.219  108.757 1.00 92.39  ? 8   GLN B C   1 
ATOM 4485 O O   . GLN B 1 8   ? 153.751 93.609  109.307 1.00 91.70  ? 8   GLN B O   1 
ATOM 4486 C CB  . GLN B 1 8   ? 152.864 91.036  107.528 1.00 93.42  ? 8   GLN B CB  1 
ATOM 4487 C CG  . GLN B 1 8   ? 154.347 91.233  107.235 1.00 92.51  ? 8   GLN B CG  1 
ATOM 4488 C CD  . GLN B 1 8   ? 155.242 90.706  108.339 1.00 93.14  ? 8   GLN B CD  1 
ATOM 4489 O OE1 . GLN B 1 8   ? 155.738 91.467  109.170 1.00 93.29  ? 8   GLN B OE1 1 
ATOM 4490 N NE2 . GLN B 1 8   ? 155.468 89.398  108.342 1.00 93.29  ? 8   GLN B NE2 1 
ATOM 4491 N N   . SER B 1 9   ? 151.868 94.055  108.147 1.00 91.38  ? 9   SER B N   1 
ATOM 4492 C CA  . SER B 1 9   ? 152.156 95.485  108.063 1.00 89.37  ? 9   SER B CA  1 
ATOM 4493 C C   . SER B 1 9   ? 152.097 96.163  109.426 1.00 89.10  ? 9   SER B C   1 
ATOM 4494 O O   . SER B 1 9   ? 152.610 97.274  109.586 1.00 89.69  ? 9   SER B O   1 
ATOM 4495 C CB  . SER B 1 9   ? 151.193 96.159  107.085 1.00 87.45  ? 9   SER B CB  1 
ATOM 4496 O OG  . SER B 1 9   ? 149.861 95.734  107.306 1.00 87.72  ? 9   SER B OG  1 
ATOM 4497 N N   . LEU B 1 10  ? 151.471 95.528  110.414 1.00 87.55  ? 10  LEU B N   1 
ATOM 4498 C CA  . LEU B 1 10  ? 151.568 96.001  111.787 1.00 86.74  ? 10  LEU B CA  1 
ATOM 4499 C C   . LEU B 1 10  ? 152.842 95.529  112.477 1.00 86.48  ? 10  LEU B C   1 
ATOM 4500 O O   . LEU B 1 10  ? 153.154 96.015  113.569 1.00 85.38  ? 10  LEU B O   1 
ATOM 4501 C CB  . LEU B 1 10  ? 150.343 95.544  112.583 1.00 87.77  ? 10  LEU B CB  1 
ATOM 4502 C CG  . LEU B 1 10  ? 149.890 96.410  113.759 1.00 87.95  ? 10  LEU B CG  1 
ATOM 4503 C CD1 . LEU B 1 10  ? 149.355 97.737  113.265 1.00 86.68  ? 10  LEU B CD1 1 
ATOM 4504 C CD2 . LEU B 1 10  ? 148.830 95.676  114.558 1.00 83.78  ? 10  LEU B CD2 1 
ATOM 4505 N N   . VAL B 1 11  ? 153.585 94.611  111.863 1.00 88.30  ? 11  VAL B N   1 
ATOM 4506 C CA  . VAL B 1 11  ? 154.776 94.040  112.487 1.00 86.30  ? 11  VAL B CA  1 
ATOM 4507 C C   . VAL B 1 11  ? 156.052 94.679  111.944 1.00 87.84  ? 11  VAL B C   1 
ATOM 4508 O O   . VAL B 1 11  ? 157.029 94.845  112.679 1.00 86.58  ? 11  VAL B O   1 
ATOM 4509 C CB  . VAL B 1 11  ? 154.769 92.507  112.288 1.00 85.44  ? 11  VAL B CB  1 
ATOM 4510 C CG1 . VAL B 1 11  ? 155.985 91.849  112.931 1.00 82.01  ? 11  VAL B CG1 1 
ATOM 4511 C CG2 . VAL B 1 11  ? 153.492 91.910  112.853 1.00 86.14  ? 11  VAL B CG2 1 
ATOM 4512 N N   . THR B 1 12  ? 156.055 95.075  110.667 1.00 93.09  ? 12  THR B N   1 
ATOM 4513 C CA  . THR B 1 12  ? 157.280 95.571  110.041 1.00 93.18  ? 12  THR B CA  1 
ATOM 4514 C C   . THR B 1 12  ? 157.716 96.919  110.607 1.00 93.52  ? 12  THR B C   1 
ATOM 4515 O O   . THR B 1 12  ? 158.899 97.267  110.522 1.00 93.39  ? 12  THR B O   1 
ATOM 4516 C CB  . THR B 1 12  ? 157.101 95.671  108.525 1.00 92.70  ? 12  THR B CB  1 
ATOM 4517 O OG1 . THR B 1 12  ? 158.175 96.435  107.963 1.00 91.44  ? 12  THR B OG1 1 
ATOM 4518 C CG2 . THR B 1 12  ? 155.786 96.347  108.185 1.00 90.22  ? 12  THR B CG2 1 
ATOM 4519 N N   . LEU B 1 13  ? 156.794 97.684  111.188 1.00 88.04  ? 13  LEU B N   1 
ATOM 4520 C CA  . LEU B 1 13  ? 157.121 98.956  111.832 1.00 89.65  ? 13  LEU B CA  1 
ATOM 4521 C C   . LEU B 1 13  ? 157.107 98.849  113.350 1.00 89.34  ? 13  LEU B C   1 
ATOM 4522 O O   . LEU B 1 13  ? 156.657 99.771  114.033 1.00 87.57  ? 13  LEU B O   1 
ATOM 4523 C CB  . LEU B 1 13  ? 156.174 100.062 111.373 1.00 87.40  ? 13  LEU B CB  1 
ATOM 4524 C CG  . LEU B 1 13  ? 155.992 100.316 109.877 1.00 89.88  ? 13  LEU B CG  1 
ATOM 4525 C CD1 . LEU B 1 13  ? 154.692 99.730  109.381 1.00 86.68  ? 13  LEU B CD1 1 
ATOM 4526 C CD2 . LEU B 1 13  ? 156.049 101.809 109.587 1.00 93.36  ? 13  LEU B CD2 1 
ATOM 4527 N N   . ALA B 1 14  ? 157.596 97.744  113.909 1.00 84.68  ? 14  ALA B N   1 
ATOM 4528 C CA  . ALA B 1 14  ? 157.580 97.545  115.353 1.00 84.30  ? 14  ALA B CA  1 
ATOM 4529 C C   . ALA B 1 14  ? 158.937 97.779  116.007 1.00 86.66  ? 14  ALA B C   1 
ATOM 4530 O O   . ALA B 1 14  ? 159.016 98.458  117.035 1.00 85.63  ? 14  ALA B O   1 
ATOM 4531 C CB  . ALA B 1 14  ? 157.085 96.134  115.680 1.00 84.78  ? 14  ALA B CB  1 
ATOM 4532 N N   . GLU B 1 15  ? 160.007 97.219  115.434 1.00 87.39  ? 15  GLU B N   1 
ATOM 4533 C CA  . GLU B 1 15  ? 161.329 97.342  116.045 1.00 89.07  ? 15  GLU B CA  1 
ATOM 4534 C C   . GLU B 1 15  ? 161.847 98.774  115.977 1.00 89.56  ? 15  GLU B C   1 
ATOM 4535 O O   . GLU B 1 15  ? 162.417 99.277  116.954 1.00 85.96  ? 15  GLU B O   1 
ATOM 4536 C CB  . GLU B 1 15  ? 162.311 96.384  115.372 1.00 87.57  ? 15  GLU B CB  1 
ATOM 4537 C CG  . GLU B 1 15  ? 163.732 96.467  115.915 1.00 85.85  ? 15  GLU B CG  1 
ATOM 4538 C CD  . GLU B 1 15  ? 163.795 96.285  117.420 1.00 85.83  ? 15  GLU B CD  1 
ATOM 4539 O OE1 . GLU B 1 15  ? 163.318 95.242  117.914 1.00 85.65  ? 15  GLU B OE1 1 
ATOM 4540 O OE2 . GLU B 1 15  ? 164.323 97.184  118.110 1.00 82.46  ? 15  GLU B OE2 1 
ATOM 4541 N N   . ASP B 1 16  ? 161.663 99.441  114.833 1.00 87.35  ? 16  ASP B N   1 
ATOM 4542 C CA  . ASP B 1 16  ? 162.070 100.839 114.723 1.00 87.57  ? 16  ASP B CA  1 
ATOM 4543 C C   . ASP B 1 16  ? 161.261 101.719 115.668 1.00 91.16  ? 16  ASP B C   1 
ATOM 4544 O O   . ASP B 1 16  ? 161.814 102.622 116.305 1.00 91.44  ? 16  ASP B O   1 
ATOM 4545 C CB  . ASP B 1 16  ? 161.946 101.322 113.274 1.00 87.54  ? 16  ASP B CB  1 
ATOM 4546 C CG  . ASP B 1 16  ? 160.641 100.901 112.612 1.00 87.51  ? 16  ASP B CG  1 
ATOM 4547 O OD1 . ASP B 1 16  ? 159.652 100.638 113.324 1.00 86.47  ? 16  ASP B OD1 1 
ATOM 4548 O OD2 . ASP B 1 16  ? 160.609 100.832 111.366 1.00 87.59  ? 16  ASP B OD2 1 
ATOM 4549 N N   . ASN B 1 17  ? 159.960 101.435 115.803 1.00 88.32  ? 17  ASN B N   1 
ATOM 4550 C CA  . ASN B 1 17  ? 159.102 102.204 116.700 1.00 85.29  ? 17  ASN B CA  1 
ATOM 4551 C C   . ASN B 1 17  ? 159.572 102.058 118.142 1.00 85.40  ? 17  ASN B C   1 
ATOM 4552 O O   . ASN B 1 17  ? 159.553 103.031 118.905 1.00 84.67  ? 17  ASN B O   1 
ATOM 4553 C CB  . ASN B 1 17  ? 157.640 101.758 116.493 1.00 83.28  ? 17  ASN B CB  1 
ATOM 4554 C CG  . ASN B 1 17  ? 156.638 102.324 117.526 1.00 79.51  ? 17  ASN B CG  1 
ATOM 4555 O OD1 . ASN B 1 17  ? 156.780 102.196 118.743 1.00 83.93  ? 17  ASN B OD1 1 
ATOM 4556 N ND2 . ASN B 1 17  ? 155.605 102.972 117.005 1.00 83.97  ? 17  ASN B ND2 1 
ATOM 4557 N N   . ILE B 1 18  ? 160.001 100.857 118.530 1.00 85.44  ? 18  ILE B N   1 
ATOM 4558 C CA  . ILE B 1 18  ? 160.578 100.677 119.859 1.00 85.47  ? 18  ILE B CA  1 
ATOM 4559 C C   . ILE B 1 18  ? 161.921 101.396 119.961 1.00 85.77  ? 18  ILE B C   1 
ATOM 4560 O O   . ILE B 1 18  ? 162.208 102.066 120.961 1.00 85.82  ? 18  ILE B O   1 
ATOM 4561 C CB  . ILE B 1 18  ? 160.694 99.177  120.188 1.00 85.92  ? 18  ILE B CB  1 
ATOM 4562 C CG1 . ILE B 1 18  ? 159.300 98.560  120.315 1.00 85.16  ? 18  ILE B CG1 1 
ATOM 4563 C CG2 . ILE B 1 18  ? 161.473 98.956  121.477 1.00 85.98  ? 18  ILE B CG2 1 
ATOM 4564 C CD1 . ILE B 1 18  ? 159.296 97.054  120.295 1.00 84.51  ? 18  ILE B CD1 1 
ATOM 4565 N N   . ALA B 1 19  ? 162.752 101.294 118.920 1.00 88.97  ? 19  ALA B N   1 
ATOM 4566 C CA  . ALA B 1 19  ? 164.051 101.957 118.932 1.00 90.60  ? 19  ALA B CA  1 
ATOM 4567 C C   . ALA B 1 19  ? 163.939 103.475 118.837 1.00 90.90  ? 19  ALA B C   1 
ATOM 4568 O O   . ALA B 1 19  ? 164.867 104.176 119.255 1.00 92.06  ? 19  ALA B O   1 
ATOM 4569 C CB  . ALA B 1 19  ? 164.920 101.428 117.791 1.00 89.26  ? 19  ALA B CB  1 
ATOM 4570 N N   . PHE B 1 20  ? 162.834 103.994 118.295 1.00 92.10  ? 20  PHE B N   1 
ATOM 4571 C CA  . PHE B 1 20  ? 162.666 105.441 118.186 1.00 92.42  ? 20  PHE B CA  1 
ATOM 4572 C C   . PHE B 1 20  ? 162.425 106.086 119.546 1.00 94.67  ? 20  PHE B C   1 
ATOM 4573 O O   . PHE B 1 20  ? 162.888 107.204 119.797 1.00 92.67  ? 20  PHE B O   1 
ATOM 4574 C CB  . PHE B 1 20  ? 161.515 105.765 117.231 1.00 94.24  ? 20  PHE B CB  1 
ATOM 4575 C CG  . PHE B 1 20  ? 161.959 106.298 115.896 1.00 94.59  ? 20  PHE B CG  1 
ATOM 4576 C CD1 . PHE B 1 20  ? 162.943 105.654 115.164 1.00 94.49  ? 20  PHE B CD1 1 
ATOM 4577 C CD2 . PHE B 1 20  ? 161.368 107.430 115.361 1.00 90.83  ? 20  PHE B CD2 1 
ATOM 4578 C CE1 . PHE B 1 20  ? 163.344 106.137 113.934 1.00 94.77  ? 20  PHE B CE1 1 
ATOM 4579 C CE2 . PHE B 1 20  ? 161.763 107.919 114.130 1.00 91.13  ? 20  PHE B CE2 1 
ATOM 4580 C CZ  . PHE B 1 20  ? 162.752 107.272 113.416 1.00 95.89  ? 20  PHE B CZ  1 
ATOM 4581 N N   . PHE B 1 21  ? 161.707 105.405 120.436 1.00 93.94  ? 21  PHE B N   1 
ATOM 4582 C CA  . PHE B 1 21  ? 161.295 106.014 121.694 1.00 91.72  ? 21  PHE B CA  1 
ATOM 4583 C C   . PHE B 1 21  ? 162.101 105.543 122.896 1.00 95.04  ? 21  PHE B C   1 
ATOM 4584 O O   . PHE B 1 21  ? 162.337 106.335 123.813 1.00 97.35  ? 21  PHE B O   1 
ATOM 4585 C CB  . PHE B 1 21  ? 159.809 105.743 121.950 1.00 91.61  ? 21  PHE B CB  1 
ATOM 4586 C CG  . PHE B 1 21  ? 159.089 106.890 122.599 1.00 90.50  ? 21  PHE B CG  1 
ATOM 4587 C CD1 . PHE B 1 21  ? 159.164 107.086 123.966 1.00 92.87  ? 21  PHE B CD1 1 
ATOM 4588 C CD2 . PHE B 1 21  ? 158.340 107.774 121.840 1.00 90.67  ? 21  PHE B CD2 1 
ATOM 4589 C CE1 . PHE B 1 21  ? 158.505 108.139 124.569 1.00 95.08  ? 21  PHE B CE1 1 
ATOM 4590 C CE2 . PHE B 1 21  ? 157.677 108.831 122.436 1.00 93.14  ? 21  PHE B CE2 1 
ATOM 4591 C CZ  . PHE B 1 21  ? 157.763 109.014 123.803 1.00 94.78  ? 21  PHE B CZ  1 
ATOM 4592 N N   . SER B 1 22  ? 162.528 104.280 122.921 1.00 85.75  ? 22  SER B N   1 
ATOM 4593 C CA  . SER B 1 22  ? 163.289 103.772 124.055 1.00 88.42  ? 22  SER B CA  1 
ATOM 4594 C C   . SER B 1 22  ? 164.726 104.277 124.080 1.00 88.63  ? 22  SER B C   1 
ATOM 4595 O O   . SER B 1 22  ? 165.343 104.294 125.150 1.00 88.48  ? 22  SER B O   1 
ATOM 4596 C CB  . SER B 1 22  ? 163.282 102.242 124.053 1.00 88.28  ? 22  SER B CB  1 
ATOM 4597 O OG  . SER B 1 22  ? 163.689 101.733 122.795 1.00 88.33  ? 22  SER B OG  1 
ATOM 4598 N N   . SER B 1 23  ? 165.271 104.685 122.936 1.00 92.17  ? 23  SER B N   1 
ATOM 4599 C CA  . SER B 1 23  ? 166.630 105.203 122.860 1.00 91.83  ? 23  SER B CA  1 
ATOM 4600 C C   . SER B 1 23  ? 166.690 106.723 122.918 1.00 92.49  ? 23  SER B C   1 
ATOM 4601 O O   . SER B 1 23  ? 167.783 107.289 122.822 1.00 91.72  ? 23  SER B O   1 
ATOM 4602 C CB  . SER B 1 23  ? 167.309 104.713 121.578 1.00 92.40  ? 23  SER B CB  1 
ATOM 4603 O OG  . SER B 1 23  ? 166.607 105.157 120.431 1.00 97.45  ? 23  SER B OG  1 
ATOM 4604 N N   . GLN B 1 24  ? 165.552 107.394 123.074 1.00 92.93  ? 24  GLN B N   1 
ATOM 4605 C CA  . GLN B 1 24  ? 165.476 108.852 123.089 1.00 94.76  ? 24  GLN B CA  1 
ATOM 4606 C C   . GLN B 1 24  ? 164.752 109.334 124.339 1.00 98.31  ? 24  GLN B C   1 
ATOM 4607 O O   . GLN B 1 24  ? 163.841 110.163 124.285 1.00 99.82  ? 24  GLN B O   1 
ATOM 4608 C CB  . GLN B 1 24  ? 164.799 109.378 121.827 1.00 94.92  ? 24  GLN B CB  1 
ATOM 4609 C CG  . GLN B 1 24  ? 165.667 109.288 120.583 1.00 94.57  ? 24  GLN B CG  1 
ATOM 4610 C CD  . GLN B 1 24  ? 164.886 109.522 119.306 1.00 96.48  ? 24  GLN B CD  1 
ATOM 4611 O OE1 . GLN B 1 24  ? 163.754 110.004 119.336 1.00 100.48 ? 24  GLN B OE1 1 
ATOM 4612 N NE2 . GLN B 1 24  ? 165.489 109.179 118.174 1.00 95.06  ? 24  GLN B NE2 1 
ATOM 4613 N N   . GLY B 1 25  ? 165.152 108.805 125.491 1.00 85.44  ? 25  GLY B N   1 
ATOM 4614 C CA  . GLY B 1 25  ? 164.596 109.226 126.754 1.00 87.39  ? 25  GLY B CA  1 
ATOM 4615 C C   . GLY B 1 25  ? 164.620 108.127 127.795 1.00 85.56  ? 25  GLY B C   1 
ATOM 4616 O O   . GLY B 1 25  ? 164.259 106.976 127.528 1.00 84.58  ? 25  GLY B O   1 
ATOM 4617 N N   . PRO B 1 26  ? 165.054 108.462 129.010 1.00 79.12  ? 26  PRO B N   1 
ATOM 4618 C CA  . PRO B 1 26  ? 165.077 107.482 130.111 1.00 78.06  ? 26  PRO B CA  1 
ATOM 4619 C C   . PRO B 1 26  ? 163.842 107.497 131.006 1.00 78.74  ? 26  PRO B C   1 
ATOM 4620 O O   . PRO B 1 26  ? 163.861 106.821 132.040 1.00 78.60  ? 26  PRO B O   1 
ATOM 4621 C CB  . PRO B 1 26  ? 166.315 107.919 130.907 1.00 78.81  ? 26  PRO B CB  1 
ATOM 4622 C CG  . PRO B 1 26  ? 166.734 109.288 130.353 1.00 80.87  ? 26  PRO B CG  1 
ATOM 4623 C CD  . PRO B 1 26  ? 165.668 109.735 129.412 1.00 82.94  ? 26  PRO B CD  1 
ATOM 4624 N N   . GLY B 1 27  ? 162.794 108.235 130.643 1.00 76.93  ? 27  GLY B N   1 
ATOM 4625 C CA  . GLY B 1 27  ? 161.614 108.350 131.471 1.00 78.29  ? 27  GLY B CA  1 
ATOM 4626 C C   . GLY B 1 27  ? 160.728 107.121 131.407 1.00 78.61  ? 27  GLY B C   1 
ATOM 4627 O O   . GLY B 1 27  ? 161.024 106.127 130.743 1.00 78.80  ? 27  GLY B O   1 
ATOM 4628 N N   . GLU B 1 28  ? 159.609 107.198 132.135 1.00 83.04  ? 28  GLU B N   1 
ATOM 4629 C CA  . GLU B 1 28  ? 158.677 106.076 132.177 1.00 83.24  ? 28  GLU B CA  1 
ATOM 4630 C C   . GLU B 1 28  ? 157.967 105.881 130.844 1.00 83.33  ? 28  GLU B C   1 
ATOM 4631 O O   . GLU B 1 28  ? 157.616 104.748 130.489 1.00 82.94  ? 28  GLU B O   1 
ATOM 4632 C CB  . GLU B 1 28  ? 157.659 106.274 133.299 1.00 85.02  ? 28  GLU B CB  1 
ATOM 4633 C CG  . GLU B 1 28  ? 157.077 107.670 133.389 1.00 84.28  ? 28  GLU B CG  1 
ATOM 4634 C CD  . GLU B 1 28  ? 156.199 107.840 134.608 1.00 83.35  ? 28  GLU B CD  1 
ATOM 4635 O OE1 . GLU B 1 28  ? 156.099 106.881 135.401 1.00 86.01  ? 28  GLU B OE1 1 
ATOM 4636 O OE2 . GLU B 1 28  ? 155.610 108.927 134.776 1.00 85.82  ? 28  GLU B OE2 1 
ATOM 4637 N N   . THR B 1 29  ? 157.778 106.965 130.088 1.00 85.37  ? 29  THR B N   1 
ATOM 4638 C CA  . THR B 1 29  ? 156.995 106.905 128.859 1.00 83.45  ? 29  THR B CA  1 
ATOM 4639 C C   . THR B 1 29  ? 157.680 106.080 127.776 1.00 83.35  ? 29  THR B C   1 
ATOM 4640 O O   . THR B 1 29  ? 156.997 105.523 126.911 1.00 83.36  ? 29  THR B O   1 
ATOM 4641 C CB  . THR B 1 29  ? 156.717 108.318 128.354 1.00 82.04  ? 29  THR B CB  1 
ATOM 4642 O OG1 . THR B 1 29  ? 157.940 108.915 127.908 1.00 84.23  ? 29  THR B OG1 1 
ATOM 4643 C CG2 . THR B 1 29  ? 156.124 109.164 129.471 1.00 80.47  ? 29  THR B CG2 1 
ATOM 4644 N N   . ALA B 1 30  ? 159.012 105.982 127.806 1.00 80.92  ? 30  ALA B N   1 
ATOM 4645 C CA  . ALA B 1 30  ? 159.710 105.114 126.861 1.00 83.94  ? 30  ALA B CA  1 
ATOM 4646 C C   . ALA B 1 30  ? 159.342 103.653 127.084 1.00 84.34  ? 30  ALA B C   1 
ATOM 4647 O O   . ALA B 1 30  ? 159.020 102.928 126.133 1.00 84.24  ? 30  ALA B O   1 
ATOM 4648 C CB  . ALA B 1 30  ? 161.220 105.314 126.979 1.00 85.46  ? 30  ALA B CB  1 
ATOM 4649 N N   . GLN B 1 31  ? 159.363 103.211 128.346 1.00 87.41  ? 31  GLN B N   1 
ATOM 4650 C CA  . GLN B 1 31  ? 158.947 101.849 128.662 1.00 88.07  ? 31  GLN B CA  1 
ATOM 4651 C C   . GLN B 1 31  ? 157.467 101.643 128.367 1.00 86.85  ? 31  GLN B C   1 
ATOM 4652 O O   . GLN B 1 31  ? 157.073 100.577 127.880 1.00 88.50  ? 31  GLN B O   1 
ATOM 4653 C CB  . GLN B 1 31  ? 159.261 101.509 130.122 1.00 87.00  ? 31  GLN B CB  1 
ATOM 4654 C CG  . GLN B 1 31  ? 160.754 101.451 130.448 1.00 89.09  ? 31  GLN B CG  1 
ATOM 4655 C CD  . GLN B 1 31  ? 161.353 102.806 130.779 1.00 89.56  ? 31  GLN B CD  1 
ATOM 4656 O OE1 . GLN B 1 31  ? 162.432 103.159 130.304 1.00 86.21  ? 31  GLN B OE1 1 
ATOM 4657 N NE2 . GLN B 1 31  ? 160.684 103.542 131.649 1.00 89.81  ? 31  GLN B NE2 1 
ATOM 4658 N N   . ARG B 1 32  ? 156.639 102.661 128.640 1.00 84.22  ? 32  ARG B N   1 
ATOM 4659 C CA  . ARG B 1 32  ? 155.211 102.566 128.338 1.00 84.14  ? 32  ARG B CA  1 
ATOM 4660 C C   . ARG B 1 32  ? 154.965 102.363 126.847 1.00 84.62  ? 32  ARG B C   1 
ATOM 4661 O O   . ARG B 1 32  ? 154.222 101.461 126.451 1.00 86.17  ? 32  ARG B O   1 
ATOM 4662 C CB  . ARG B 1 32  ? 154.479 103.818 128.822 1.00 82.62  ? 32  ARG B CB  1 
ATOM 4663 C CG  . ARG B 1 32  ? 154.510 104.062 130.319 1.00 82.43  ? 32  ARG B CG  1 
ATOM 4664 C CD  . ARG B 1 32  ? 153.234 103.615 131.002 1.00 80.65  ? 32  ARG B CD  1 
ATOM 4665 N NE  . ARG B 1 32  ? 153.046 104.314 132.267 1.00 84.06  ? 32  ARG B NE  1 
ATOM 4666 C CZ  . ARG B 1 32  ? 152.123 104.006 133.166 1.00 85.21  ? 32  ARG B CZ  1 
ATOM 4667 N NH1 . ARG B 1 32  ? 151.281 103.004 132.977 1.00 85.54  ? 32  ARG B NH1 1 
ATOM 4668 N NH2 . ARG B 1 32  ? 152.043 104.719 134.286 1.00 87.66  ? 32  ARG B NH2 1 
ATOM 4669 N N   . LEU B 1 33  ? 155.606 103.174 126.002 1.00 81.51  ? 33  LEU B N   1 
ATOM 4670 C CA  . LEU B 1 33  ? 155.364 103.082 124.566 1.00 81.64  ? 33  LEU B CA  1 
ATOM 4671 C C   . LEU B 1 33  ? 155.964 101.809 123.978 1.00 81.65  ? 33  LEU B C   1 
ATOM 4672 O O   . LEU B 1 33  ? 155.362 101.191 123.088 1.00 87.73  ? 33  LEU B O   1 
ATOM 4673 C CB  . LEU B 1 33  ? 155.913 104.322 123.860 1.00 84.86  ? 33  LEU B CB  1 
ATOM 4674 C CG  . LEU B 1 33  ? 155.435 104.573 122.427 1.00 88.54  ? 33  LEU B CG  1 
ATOM 4675 C CD1 . LEU B 1 33  ? 155.125 106.046 122.225 1.00 83.90  ? 33  LEU B CD1 1 
ATOM 4676 C CD2 . LEU B 1 33  ? 156.475 104.115 121.416 1.00 88.05  ? 33  LEU B CD2 1 
ATOM 4677 N N   . SER B 1 34  ? 157.142 101.396 124.462 1.00 72.92  ? 34  SER B N   1 
ATOM 4678 C CA  . SER B 1 34  ? 157.736 100.151 123.983 1.00 80.00  ? 34  SER B CA  1 
ATOM 4679 C C   . SER B 1 34  ? 156.879 98.947  124.357 1.00 81.98  ? 34  SER B C   1 
ATOM 4680 O O   . SER B 1 34  ? 156.646 98.060  123.525 1.00 79.39  ? 34  SER B O   1 
ATOM 4681 C CB  . SER B 1 34  ? 159.151 99.998  124.536 1.00 82.32  ? 34  SER B CB  1 
ATOM 4682 O OG  . SER B 1 34  ? 159.812 101.249 124.588 1.00 85.85  ? 34  SER B OG  1 
ATOM 4683 N N   . GLY B 1 35  ? 156.381 98.911  125.597 1.00 79.63  ? 35  GLY B N   1 
ATOM 4684 C CA  . GLY B 1 35  ? 155.485 97.839  125.996 1.00 74.77  ? 35  GLY B CA  1 
ATOM 4685 C C   . GLY B 1 35  ? 154.167 97.871  125.249 1.00 71.49  ? 35  GLY B C   1 
ATOM 4686 O O   . GLY B 1 35  ? 153.600 96.822  124.938 1.00 73.27  ? 35  GLY B O   1 
ATOM 4687 N N   . VAL B 1 36  ? 153.672 99.072  124.936 1.00 66.39  ? 36  VAL B N   1 
ATOM 4688 C CA  . VAL B 1 36  ? 152.427 99.203  124.183 1.00 63.04  ? 36  VAL B CA  1 
ATOM 4689 C C   . VAL B 1 36  ? 152.589 98.630  122.782 1.00 63.50  ? 36  VAL B C   1 
ATOM 4690 O O   . VAL B 1 36  ? 151.742 97.864  122.306 1.00 66.68  ? 36  VAL B O   1 
ATOM 4691 C CB  . VAL B 1 36  ? 151.974 100.674 124.154 1.00 64.95  ? 36  VAL B CB  1 
ATOM 4692 C CG1 . VAL B 1 36  ? 151.161 100.974 122.912 1.00 65.63  ? 36  VAL B CG1 1 
ATOM 4693 C CG2 . VAL B 1 36  ? 151.150 100.985 125.387 1.00 66.22  ? 36  VAL B CG2 1 
ATOM 4694 N N   . PHE B 1 37  ? 153.695 98.956  122.111 1.00 67.69  ? 37  PHE B N   1 
ATOM 4695 C CA  . PHE B 1 37  ? 153.834 98.468  120.744 1.00 69.17  ? 37  PHE B CA  1 
ATOM 4696 C C   . PHE B 1 37  ? 154.204 96.988  120.712 1.00 71.75  ? 37  PHE B C   1 
ATOM 4697 O O   . PHE B 1 37  ? 153.803 96.272  119.783 1.00 70.83  ? 37  PHE B O   1 
ATOM 4698 C CB  . PHE B 1 37  ? 154.848 99.306  119.970 1.00 73.42  ? 37  PHE B CB  1 
ATOM 4699 C CG  . PHE B 1 37  ? 154.417 99.606  118.563 1.00 76.86  ? 37  PHE B CG  1 
ATOM 4700 C CD1 . PHE B 1 37  ? 154.895 98.863  117.500 1.00 74.56  ? 37  PHE B CD1 1 
ATOM 4701 C CD2 . PHE B 1 37  ? 153.510 100.624 118.311 1.00 75.92  ? 37  PHE B CD2 1 
ATOM 4702 C CE1 . PHE B 1 37  ? 154.483 99.136  116.211 1.00 76.55  ? 37  PHE B CE1 1 
ATOM 4703 C CE2 . PHE B 1 37  ? 153.097 100.902 117.024 1.00 75.08  ? 37  PHE B CE2 1 
ATOM 4704 C CZ  . PHE B 1 37  ? 153.587 100.159 115.972 1.00 79.15  ? 37  PHE B CZ  1 
ATOM 4705 N N   . ALA B 1 38  ? 154.932 96.504  121.727 1.00 69.34  ? 38  ALA B N   1 
ATOM 4706 C CA  . ALA B 1 38  ? 155.166 95.067  121.851 1.00 65.78  ? 38  ALA B CA  1 
ATOM 4707 C C   . ALA B 1 38  ? 153.863 94.310  122.089 1.00 65.01  ? 38  ALA B C   1 
ATOM 4708 O O   . ALA B 1 38  ? 153.637 93.247  121.495 1.00 66.98  ? 38  ALA B O   1 
ATOM 4709 C CB  . ALA B 1 38  ? 156.162 94.792  122.976 1.00 66.58  ? 38  ALA B CB  1 
ATOM 4710 N N   . GLY B 1 39  ? 152.989 94.848  122.945 1.00 64.56  ? 39  GLY B N   1 
ATOM 4711 C CA  . GLY B 1 39  ? 151.692 94.232  123.153 1.00 55.11  ? 39  GLY B CA  1 
ATOM 4712 C C   . GLY B 1 39  ? 150.830 94.255  121.906 1.00 56.18  ? 39  GLY B C   1 
ATOM 4713 O O   . GLY B 1 39  ? 150.119 93.292  121.621 1.00 58.66  ? 39  GLY B O   1 
ATOM 4714 N N   . VAL B 1 40  ? 150.901 95.344  121.136 1.00 64.16  ? 40  VAL B N   1 
ATOM 4715 C CA  . VAL B 1 40  ? 150.124 95.444  119.903 1.00 62.58  ? 40  VAL B CA  1 
ATOM 4716 C C   . VAL B 1 40  ? 150.593 94.412  118.881 1.00 59.20  ? 40  VAL B C   1 
ATOM 4717 O O   . VAL B 1 40  ? 149.772 93.701  118.278 1.00 58.21  ? 40  VAL B O   1 
ATOM 4718 C CB  . VAL B 1 40  ? 150.197 96.880  119.352 1.00 55.72  ? 40  VAL B CB  1 
ATOM 4719 C CG1 . VAL B 1 40  ? 149.944 96.913  117.854 1.00 49.84  ? 40  VAL B CG1 1 
ATOM 4720 C CG2 . VAL B 1 40  ? 149.201 97.766  120.080 1.00 58.11  ? 40  VAL B CG2 1 
ATOM 4721 N N   . ARG B 1 41  ? 151.913 94.283  118.695 1.00 50.09  ? 41  ARG B N   1 
ATOM 4722 C CA  . ARG B 1 41  ? 152.410 93.310  117.725 1.00 54.11  ? 41  ARG B CA  1 
ATOM 4723 C C   . ARG B 1 41  ? 152.130 91.876  118.178 1.00 61.62  ? 41  ARG B C   1 
ATOM 4724 O O   . ARG B 1 41  ? 151.759 91.028  117.354 1.00 59.52  ? 41  ARG B O   1 
ATOM 4725 C CB  . ARG B 1 41  ? 153.902 93.531  117.441 1.00 59.61  ? 41  ARG B CB  1 
ATOM 4726 C CG  . ARG B 1 41  ? 154.863 93.193  118.565 1.00 59.47  ? 41  ARG B CG  1 
ATOM 4727 C CD  . ARG B 1 41  ? 156.148 93.983  118.474 1.00 62.05  ? 41  ARG B CD  1 
ATOM 4728 N NE  . ARG B 1 41  ? 157.206 93.399  119.290 1.00 63.18  ? 41  ARG B NE  1 
ATOM 4729 C CZ  . ARG B 1 41  ? 158.498 93.650  119.133 1.00 60.27  ? 41  ARG B CZ  1 
ATOM 4730 N NH1 . ARG B 1 41  ? 158.935 94.452  118.176 1.00 61.24  ? 41  ARG B NH1 1 
ATOM 4731 N NH2 . ARG B 1 41  ? 159.375 93.079  119.955 1.00 60.19  ? 41  ARG B NH2 1 
ATOM 4732 N N   . GLU B 1 42  ? 152.231 91.594  119.486 1.00 62.53  ? 42  GLU B N   1 
ATOM 4733 C CA  . GLU B 1 42  ? 151.977 90.228  119.934 1.00 61.95  ? 42  GLU B CA  1 
ATOM 4734 C C   . GLU B 1 42  ? 150.489 89.894  119.906 1.00 55.51  ? 42  GLU B C   1 
ATOM 4735 O O   . GLU B 1 42  ? 150.127 88.753  119.602 1.00 53.91  ? 42  GLU B O   1 
ATOM 4736 C CB  . GLU B 1 42  ? 152.579 89.990  121.325 1.00 61.42  ? 42  GLU B CB  1 
ATOM 4737 C CG  . GLU B 1 42  ? 151.865 90.646  122.493 1.00 60.47  ? 42  GLU B CG  1 
ATOM 4738 C CD  . GLU B 1 42  ? 152.136 89.946  123.808 1.00 54.41  ? 42  GLU B CD  1 
ATOM 4739 O OE1 . GLU B 1 42  ? 152.885 88.947  123.806 1.00 57.77  ? 42  GLU B OE1 1 
ATOM 4740 O OE2 . GLU B 1 42  ? 151.601 90.394  124.844 1.00 57.75  ? 42  GLU B OE2 1 
ATOM 4741 N N   . GLN B 1 43  ? 149.614 90.876  120.159 1.00 52.68  ? 43  GLN B N   1 
ATOM 4742 C CA  . GLN B 1 43  ? 148.180 90.630  120.064 1.00 52.38  ? 43  GLN B CA  1 
ATOM 4743 C C   . GLN B 1 43  ? 147.758 90.383  118.623 1.00 52.81  ? 43  GLN B C   1 
ATOM 4744 O O   . GLN B 1 43  ? 146.966 89.472  118.360 1.00 53.10  ? 43  GLN B O   1 
ATOM 4745 C CB  . GLN B 1 43  ? 147.396 91.799  120.657 1.00 44.70  ? 43  GLN B CB  1 
ATOM 4746 C CG  . GLN B 1 43  ? 147.320 91.796  122.172 1.00 50.58  ? 43  GLN B CG  1 
ATOM 4747 C CD  . GLN B 1 43  ? 147.130 90.413  122.749 1.00 53.23  ? 43  GLN B CD  1 
ATOM 4748 O OE1 . GLN B 1 43  ? 146.118 89.763  122.507 1.00 59.45  ? 43  GLN B OE1 1 
ATOM 4749 N NE2 . GLN B 1 43  ? 148.107 89.955  123.518 1.00 50.14  ? 43  GLN B NE2 1 
ATOM 4750 N N   . ALA B 1 44  ? 148.288 91.165  117.674 1.00 58.44  ? 44  ALA B N   1 
ATOM 4751 C CA  . ALA B 1 44  ? 147.975 90.917  116.268 1.00 56.62  ? 44  ALA B CA  1 
ATOM 4752 C C   . ALA B 1 44  ? 148.485 89.553  115.814 1.00 53.61  ? 44  ALA B C   1 
ATOM 4753 O O   . ALA B 1 44  ? 147.748 88.785  115.175 1.00 57.27  ? 44  ALA B O   1 
ATOM 4754 C CB  . ALA B 1 44  ? 148.561 92.022  115.392 1.00 59.46  ? 44  ALA B CB  1 
ATOM 4755 N N   . LEU B 1 45  ? 149.727 89.213  116.178 1.00 44.32  ? 45  LEU B N   1 
ATOM 4756 C CA  . LEU B 1 45  ? 150.325 87.967  115.709 1.00 55.39  ? 45  LEU B CA  1 
ATOM 4757 C C   . LEU B 1 45  ? 149.671 86.749  116.356 1.00 63.60  ? 45  LEU B C   1 
ATOM 4758 O O   . LEU B 1 45  ? 149.608 85.674  115.748 1.00 60.38  ? 45  LEU B O   1 
ATOM 4759 C CB  . LEU B 1 45  ? 151.830 87.982  115.974 1.00 54.26  ? 45  LEU B CB  1 
ATOM 4760 C CG  . LEU B 1 45  ? 152.735 87.484  114.844 1.00 52.51  ? 45  LEU B CG  1 
ATOM 4761 C CD1 . LEU B 1 45  ? 152.259 87.993  113.490 1.00 59.55  ? 45  LEU B CD1 1 
ATOM 4762 C CD2 . LEU B 1 45  ? 154.175 87.902  115.097 1.00 56.96  ? 45  LEU B CD2 1 
ATOM 4763 N N   . GLY B 1 46  ? 149.179 86.890  117.590 1.00 64.89  ? 46  GLY B N   1 
ATOM 4764 C CA  . GLY B 1 46  ? 148.509 85.776  118.238 1.00 58.83  ? 46  GLY B CA  1 
ATOM 4765 C C   . GLY B 1 46  ? 147.030 85.675  117.929 1.00 56.51  ? 46  GLY B C   1 
ATOM 4766 O O   . GLY B 1 46  ? 146.448 84.599  118.094 1.00 58.10  ? 46  GLY B O   1 
ATOM 4767 N N   . LEU B 1 47  ? 146.411 86.765  117.478 1.00 57.39  ? 47  LEU B N   1 
ATOM 4768 C CA  . LEU B 1 47  ? 144.996 86.750  117.149 1.00 47.38  ? 47  LEU B CA  1 
ATOM 4769 C C   . LEU B 1 47  ? 144.741 86.437  115.681 1.00 53.01  ? 47  LEU B C   1 
ATOM 4770 O O   . LEU B 1 47  ? 143.615 86.067  115.330 1.00 55.19  ? 47  LEU B O   1 
ATOM 4771 C CB  . LEU B 1 47  ? 144.379 88.098  117.556 1.00 40.93  ? 47  LEU B CB  1 
ATOM 4772 C CG  . LEU B 1 47  ? 143.016 88.631  117.115 1.00 50.92  ? 47  LEU B CG  1 
ATOM 4773 C CD1 . LEU B 1 47  ? 142.352 89.356  118.265 1.00 56.54  ? 47  LEU B CD1 1 
ATOM 4774 C CD2 . LEU B 1 47  ? 143.175 89.568  115.933 1.00 54.30  ? 47  LEU B CD2 1 
ATOM 4775 N N   . GLU B 1 48  ? 145.764 86.550  114.826 1.00 67.12  ? 48  GLU B N   1 
ATOM 4776 C CA  . GLU B 1 48  ? 145.612 86.165  113.420 1.00 66.51  ? 48  GLU B CA  1 
ATOM 4777 C C   . GLU B 1 48  ? 145.155 84.718  113.181 1.00 67.09  ? 48  GLU B C   1 
ATOM 4778 O O   . GLU B 1 48  ? 144.222 84.528  112.377 1.00 65.40  ? 48  GLU B O   1 
ATOM 4779 C CB  . GLU B 1 48  ? 146.919 86.462  112.674 1.00 64.74  ? 48  GLU B CB  1 
ATOM 4780 C CG  . GLU B 1 48  ? 147.024 85.793  111.314 1.00 67.63  ? 48  GLU B CG  1 
ATOM 4781 C CD  . GLU B 1 48  ? 148.410 85.905  110.718 1.00 63.02  ? 48  GLU B CD  1 
ATOM 4782 O OE1 . GLU B 1 48  ? 148.984 87.013  110.753 1.00 64.93  ? 48  GLU B OE1 1 
ATOM 4783 O OE2 . GLU B 1 48  ? 148.927 84.885  110.217 1.00 53.83  ? 48  GLU B OE2 1 
ATOM 4784 N N   . PRO B 1 49  ? 145.737 83.667  113.798 1.00 62.54  ? 49  PRO B N   1 
ATOM 4785 C CA  . PRO B 1 49  ? 145.284 82.305  113.445 1.00 61.65  ? 49  PRO B CA  1 
ATOM 4786 C C   . PRO B 1 49  ? 143.867 81.985  113.896 1.00 63.40  ? 49  PRO B C   1 
ATOM 4787 O O   . PRO B 1 49  ? 143.152 81.260  113.187 1.00 65.96  ? 49  PRO B O   1 
ATOM 4788 C CB  . PRO B 1 49  ? 146.309 81.401  114.142 1.00 65.23  ? 49  PRO B CB  1 
ATOM 4789 C CG  . PRO B 1 49  ? 146.773 82.190  115.289 1.00 64.63  ? 49  PRO B CG  1 
ATOM 4790 C CD  . PRO B 1 49  ? 146.840 83.597  114.782 1.00 58.89  ? 49  PRO B CD  1 
ATOM 4791 N N   . ALA B 1 50  ? 143.440 82.506  115.049 1.00 62.79  ? 50  ALA B N   1 
ATOM 4792 C CA  . ALA B 1 50  ? 142.062 82.314  115.485 1.00 59.07  ? 50  ALA B CA  1 
ATOM 4793 C C   . ALA B 1 50  ? 141.089 82.994  114.532 1.00 55.34  ? 50  ALA B C   1 
ATOM 4794 O O   . ALA B 1 50  ? 140.023 82.447  114.225 1.00 62.34  ? 50  ALA B O   1 
ATOM 4795 C CB  . ALA B 1 50  ? 141.892 82.837  116.909 1.00 56.69  ? 50  ALA B CB  1 
ATOM 4796 N N   . LEU B 1 51  ? 141.458 84.177  114.031 1.00 56.10  ? 51  LEU B N   1 
ATOM 4797 C CA  . LEU B 1 51  ? 140.649 84.854  113.021 1.00 57.08  ? 51  LEU B CA  1 
ATOM 4798 C C   . LEU B 1 51  ? 140.576 84.045  111.731 1.00 57.89  ? 51  LEU B C   1 
ATOM 4799 O O   . LEU B 1 51  ? 139.521 83.988  111.087 1.00 58.76  ? 51  LEU B O   1 
ATOM 4800 C CB  . LEU B 1 51  ? 141.216 86.244  112.734 1.00 57.49  ? 51  LEU B CB  1 
ATOM 4801 C CG  . LEU B 1 51  ? 140.944 87.380  113.721 1.00 55.15  ? 51  LEU B CG  1 
ATOM 4802 C CD1 . LEU B 1 51  ? 141.040 88.715  112.997 1.00 55.40  ? 51  LEU B CD1 1 
ATOM 4803 C CD2 . LEU B 1 51  ? 139.598 87.222  114.412 1.00 52.65  ? 51  LEU B CD2 1 
ATOM 4804 N N   . GLY B 1 52  ? 141.689 83.423  111.330 1.00 63.31  ? 52  GLY B N   1 
ATOM 4805 C CA  . GLY B 1 52  ? 141.673 82.599  110.129 1.00 67.18  ? 52  GLY B CA  1 
ATOM 4806 C C   . GLY B 1 52  ? 140.775 81.382  110.259 1.00 63.72  ? 52  GLY B C   1 
ATOM 4807 O O   . GLY B 1 52  ? 140.013 81.054  109.339 1.00 59.86  ? 52  GLY B O   1 
ATOM 4808 N N   . ARG B 1 53  ? 140.842 80.705  111.410 1.00 63.26  ? 53  ARG B N   1 
ATOM 4809 C CA  . ARG B 1 53  ? 139.940 79.582  111.658 1.00 63.41  ? 53  ARG B CA  1 
ATOM 4810 C C   . ARG B 1 53  ? 138.484 80.038  111.670 1.00 66.49  ? 53  ARG B C   1 
ATOM 4811 O O   . ARG B 1 53  ? 137.612 79.366  111.101 1.00 67.30  ? 53  ARG B O   1 
ATOM 4812 C CB  . ARG B 1 53  ? 140.293 78.889  112.976 1.00 62.60  ? 53  ARG B CB  1 
ATOM 4813 C CG  . ARG B 1 53  ? 141.708 78.332  113.048 1.00 67.25  ? 53  ARG B CG  1 
ATOM 4814 C CD  . ARG B 1 53  ? 142.063 77.930  114.473 1.00 67.54  ? 53  ARG B CD  1 
ATOM 4815 N NE  . ARG B 1 53  ? 143.426 78.299  114.835 1.00 63.59  ? 53  ARG B NE  1 
ATOM 4816 C CZ  . ARG B 1 53  ? 143.898 78.296  116.075 1.00 63.59  ? 53  ARG B CZ  1 
ATOM 4817 N NH1 . ARG B 1 53  ? 143.140 77.948  117.102 1.00 64.85  ? 53  ARG B NH1 1 
ATOM 4818 N NH2 . ARG B 1 53  ? 145.161 78.653  116.289 1.00 65.31  ? 53  ARG B NH2 1 
ATOM 4819 N N   . LEU B 1 54  ? 138.211 81.193  112.290 1.00 64.72  ? 54  LEU B N   1 
ATOM 4820 C CA  . LEU B 1 54  ? 136.846 81.707  112.357 1.00 52.60  ? 54  LEU B CA  1 
ATOM 4821 C C   . LEU B 1 54  ? 136.304 82.063  110.976 1.00 57.14  ? 54  LEU B C   1 
ATOM 4822 O O   . LEU B 1 54  ? 135.129 81.822  110.689 1.00 58.91  ? 54  LEU B O   1 
ATOM 4823 C CB  . LEU B 1 54  ? 136.780 82.921  113.281 1.00 53.36  ? 54  LEU B CB  1 
ATOM 4824 C CG  . LEU B 1 54  ? 136.268 82.704  114.707 1.00 48.12  ? 54  LEU B CG  1 
ATOM 4825 C CD1 . LEU B 1 54  ? 135.713 84.001  115.268 1.00 54.01  ? 54  LEU B CD1 1 
ATOM 4826 C CD2 . LEU B 1 54  ? 135.227 81.600  114.776 1.00 50.03  ? 54  LEU B CD2 1 
ATOM 4827 N N   . LEU B 1 55  ? 137.133 82.633  110.099 1.00 71.13  ? 55  LEU B N   1 
ATOM 4828 C CA  . LEU B 1 55  ? 136.615 82.940  108.767 1.00 70.00  ? 55  LEU B CA  1 
ATOM 4829 C C   . LEU B 1 55  ? 136.431 81.680  107.925 1.00 67.99  ? 55  LEU B C   1 
ATOM 4830 O O   . LEU B 1 55  ? 135.482 81.609  107.129 1.00 74.13  ? 55  LEU B O   1 
ATOM 4831 C CB  . LEU B 1 55  ? 137.506 83.952  108.039 1.00 69.38  ? 55  LEU B CB  1 
ATOM 4832 C CG  . LEU B 1 55  ? 139.008 83.757  107.854 1.00 67.02  ? 55  LEU B CG  1 
ATOM 4833 C CD1 . LEU B 1 55  ? 139.314 83.136  106.503 1.00 68.12  ? 55  LEU B CD1 1 
ATOM 4834 C CD2 . LEU B 1 55  ? 139.723 85.089  108.003 1.00 62.86  ? 55  LEU B CD2 1 
ATOM 4835 N N   . GLY B 1 56  ? 137.300 80.675  108.093 1.00 58.33  ? 56  GLY B N   1 
ATOM 4836 C CA  . GLY B 1 56  ? 137.108 79.424  107.366 1.00 62.18  ? 56  GLY B CA  1 
ATOM 4837 C C   . GLY B 1 56  ? 135.821 78.716  107.750 1.00 63.21  ? 56  GLY B C   1 
ATOM 4838 O O   . GLY B 1 56  ? 135.022 78.325  106.891 1.00 58.29  ? 56  GLY B O   1 
ATOM 4839 N N   . VAL B 1 57  ? 135.571 78.590  109.054 1.00 67.55  ? 57  VAL B N   1 
ATOM 4840 C CA  . VAL B 1 57  ? 134.296 78.031  109.495 1.00 69.15  ? 57  VAL B CA  1 
ATOM 4841 C C   . VAL B 1 57  ? 133.106 78.961  109.257 1.00 67.43  ? 57  VAL B C   1 
ATOM 4842 O O   . VAL B 1 57  ? 131.964 78.488  109.221 1.00 68.47  ? 57  VAL B O   1 
ATOM 4843 C CB  . VAL B 1 57  ? 134.388 77.638  110.973 1.00 70.16  ? 57  VAL B CB  1 
ATOM 4844 C CG1 . VAL B 1 57  ? 133.034 77.718  111.630 1.00 66.99  ? 57  VAL B CG1 1 
ATOM 4845 C CG2 . VAL B 1 57  ? 134.832 76.205  111.015 1.00 67.29  ? 57  VAL B CG2 1 
ATOM 4846 N N   . ALA B 1 58  ? 133.326 80.267  109.078 1.00 66.36  ? 58  ALA B N   1 
ATOM 4847 C CA  . ALA B 1 58  ? 132.220 81.152  108.741 1.00 66.11  ? 58  ALA B CA  1 
ATOM 4848 C C   . ALA B 1 58  ? 131.784 80.939  107.302 1.00 64.44  ? 58  ALA B C   1 
ATOM 4849 O O   . ALA B 1 58  ? 130.588 80.988  106.990 1.00 64.59  ? 58  ALA B O   1 
ATOM 4850 C CB  . ALA B 1 58  ? 132.630 82.603  108.976 1.00 65.51  ? 58  ALA B CB  1 
ATOM 4851 N N   . HIS B 1 59  ? 132.751 80.708  106.414 1.00 72.37  ? 59  HIS B N   1 
ATOM 4852 C CA  . HIS B 1 59  ? 132.422 80.262  105.066 1.00 73.88  ? 59  HIS B CA  1 
ATOM 4853 C C   . HIS B 1 59  ? 131.765 78.888  105.093 1.00 76.00  ? 59  HIS B C   1 
ATOM 4854 O O   . HIS B 1 59  ? 130.855 78.610  104.302 1.00 79.01  ? 59  HIS B O   1 
ATOM 4855 C CB  . HIS B 1 59  ? 133.681 80.242  104.201 1.00 74.23  ? 59  HIS B CB  1 
ATOM 4856 C CG  . HIS B 1 59  ? 133.472 79.648  102.843 1.00 72.78  ? 59  HIS B CG  1 
ATOM 4857 N ND1 . HIS B 1 59  ? 134.376 78.785  102.264 1.00 73.61  ? 59  HIS B ND1 1 
ATOM 4858 C CD2 . HIS B 1 59  ? 132.468 79.799  101.947 1.00 73.81  ? 59  HIS B CD2 1 
ATOM 4859 C CE1 . HIS B 1 59  ? 133.935 78.423  101.073 1.00 77.28  ? 59  HIS B CE1 1 
ATOM 4860 N NE2 . HIS B 1 59  ? 132.779 79.024  100.856 1.00 73.87  ? 59  HIS B NE2 1 
ATOM 4861 N N   . LEU B 1 60  ? 132.208 78.016  106.004 1.00 81.70  ? 60  LEU B N   1 
ATOM 4862 C CA  . LEU B 1 60  ? 131.627 76.679  106.106 1.00 84.43  ? 60  LEU B CA  1 
ATOM 4863 C C   . LEU B 1 60  ? 130.233 76.675  106.732 1.00 78.97  ? 60  LEU B C   1 
ATOM 4864 O O   . LEU B 1 60  ? 129.505 75.687  106.584 1.00 77.98  ? 60  LEU B O   1 
ATOM 4865 C CB  . LEU B 1 60  ? 132.562 75.773  106.915 1.00 79.43  ? 60  LEU B CB  1 
ATOM 4866 C CG  . LEU B 1 60  ? 132.431 74.252  106.778 1.00 79.81  ? 60  LEU B CG  1 
ATOM 4867 C CD1 . LEU B 1 60  ? 133.801 73.613  106.663 1.00 79.20  ? 60  LEU B CD1 1 
ATOM 4868 C CD2 . LEU B 1 60  ? 131.671 73.659  107.960 1.00 77.96  ? 60  LEU B CD2 1 
ATOM 4869 N N   . PHE B 1 61  ? 129.831 77.750  107.415 1.00 72.93  ? 61  PHE B N   1 
ATOM 4870 C CA  . PHE B 1 61  ? 128.686 77.677  108.309 1.00 70.84  ? 61  PHE B CA  1 
ATOM 4871 C C   . PHE B 1 61  ? 127.440 78.405  107.817 1.00 73.53  ? 61  PHE B C   1 
ATOM 4872 O O   . PHE B 1 61  ? 126.338 78.048  108.243 1.00 78.32  ? 61  PHE B O   1 
ATOM 4873 C CB  . PHE B 1 61  ? 129.073 78.236  109.682 1.00 72.97  ? 61  PHE B CB  1 
ATOM 4874 C CG  . PHE B 1 61  ? 128.408 77.544  110.823 1.00 67.48  ? 61  PHE B CG  1 
ATOM 4875 C CD1 . PHE B 1 61  ? 127.317 78.106  111.451 1.00 62.85  ? 61  PHE B CD1 1 
ATOM 4876 C CD2 . PHE B 1 61  ? 128.900 76.335  111.288 1.00 71.03  ? 61  PHE B CD2 1 
ATOM 4877 C CE1 . PHE B 1 61  ? 126.712 77.465  112.508 1.00 69.66  ? 61  PHE B CE1 1 
ATOM 4878 C CE2 . PHE B 1 61  ? 128.307 75.694  112.346 1.00 73.20  ? 61  PHE B CE2 1 
ATOM 4879 C CZ  . PHE B 1 61  ? 127.206 76.255  112.956 1.00 74.02  ? 61  PHE B CZ  1 
ATOM 4880 N N   . ASP B 1 62  ? 127.578 79.409  106.951 1.00 68.71  ? 62  ASP B N   1 
ATOM 4881 C CA  . ASP B 1 62  ? 126.444 80.218  106.519 1.00 68.70  ? 62  ASP B CA  1 
ATOM 4882 C C   . ASP B 1 62  ? 125.544 79.431  105.563 1.00 68.21  ? 62  ASP B C   1 
ATOM 4883 O O   . ASP B 1 62  ? 125.941 78.422  104.974 1.00 68.78  ? 62  ASP B O   1 
ATOM 4884 C CB  . ASP B 1 62  ? 126.932 81.504  105.850 1.00 68.14  ? 62  ASP B CB  1 
ATOM 4885 C CG  . ASP B 1 62  ? 125.877 82.597  105.835 1.00 68.15  ? 62  ASP B CG  1 
ATOM 4886 O OD1 . ASP B 1 62  ? 124.877 82.449  105.101 1.00 68.53  ? 62  ASP B OD1 1 
ATOM 4887 O OD2 . ASP B 1 62  ? 126.046 83.603  106.556 1.00 67.42  ? 62  ASP B OD2 1 
ATOM 4888 N N   . LEU B 1 63  ? 124.307 79.915  105.409 1.00 72.66  ? 63  LEU B N   1 
ATOM 4889 C CA  . LEU B 1 63  ? 123.327 79.209  104.587 1.00 72.86  ? 63  LEU B CA  1 
ATOM 4890 C C   . LEU B 1 63  ? 123.501 79.515  103.103 1.00 75.93  ? 63  LEU B C   1 
ATOM 4891 O O   . LEU B 1 63  ? 123.516 78.599  102.274 1.00 75.95  ? 63  LEU B O   1 
ATOM 4892 C CB  . LEU B 1 63  ? 121.902 79.542  105.049 1.00 71.91  ? 63  LEU B CB  1 
ATOM 4893 C CG  . LEU B 1 63  ? 121.368 80.976  105.153 1.00 70.55  ? 63  LEU B CG  1 
ATOM 4894 C CD1 . LEU B 1 63  ? 120.566 81.362  103.934 1.00 75.52  ? 63  LEU B CD1 1 
ATOM 4895 C CD2 . LEU B 1 63  ? 120.483 81.075  106.348 1.00 69.78  ? 63  LEU B CD2 1 
ATOM 4896 N N   . ASP B 1 64  ? 123.632 80.789  102.745 1.00 82.33  ? 64  ASP B N   1 
ATOM 4897 C CA  . ASP B 1 64  ? 123.725 81.201  101.354 1.00 82.55  ? 64  ASP B CA  1 
ATOM 4898 C C   . ASP B 1 64  ? 124.898 82.150  101.171 1.00 80.36  ? 64  ASP B C   1 
ATOM 4899 O O   . ASP B 1 64  ? 125.245 82.901  102.089 1.00 78.32  ? 64  ASP B O   1 
ATOM 4900 C CB  . ASP B 1 64  ? 122.435 81.895  100.885 1.00 81.79  ? 64  ASP B CB  1 
ATOM 4901 C CG  . ASP B 1 64  ? 121.377 80.913  100.409 1.00 78.77  ? 64  ASP B CG  1 
ATOM 4902 O OD1 . ASP B 1 64  ? 121.188 79.865  101.060 1.00 79.13  ? 64  ASP B OD1 1 
ATOM 4903 O OD2 . ASP B 1 64  ? 120.729 81.193  99.379  1.00 75.92  ? 64  ASP B OD2 1 
ATOM 4904 N N   . PRO B 1 65  ? 125.530 82.138  99.993  1.00 81.07  ? 65  PRO B N   1 
ATOM 4905 C CA  . PRO B 1 65  ? 126.607 83.107  99.735  1.00 82.37  ? 65  PRO B CA  1 
ATOM 4906 C C   . PRO B 1 65  ? 126.116 84.533  99.569  1.00 78.89  ? 65  PRO B C   1 
ATOM 4907 O O   . PRO B 1 65  ? 126.928 85.462  99.670  1.00 78.81  ? 65  PRO B O   1 
ATOM 4908 C CB  . PRO B 1 65  ? 127.246 82.588  98.440  1.00 82.70  ? 65  PRO B CB  1 
ATOM 4909 C CG  . PRO B 1 65  ? 126.181 81.779  97.786  1.00 81.28  ? 65  PRO B CG  1 
ATOM 4910 C CD  . PRO B 1 65  ? 125.378 81.170  98.893  1.00 78.84  ? 65  PRO B CD  1 
ATOM 4911 N N   . GLU B 1 66  ? 124.821 84.737  99.314  1.00 79.64  ? 66  GLU B N   1 
ATOM 4912 C CA  . GLU B 1 66  ? 124.313 86.080  99.052  1.00 80.38  ? 66  GLU B CA  1 
ATOM 4913 C C   . GLU B 1 66  ? 124.306 86.933  100.314 1.00 79.62  ? 66  GLU B C   1 
ATOM 4914 O O   . GLU B 1 66  ? 124.575 88.139  100.254 1.00 79.52  ? 66  GLU B O   1 
ATOM 4915 C CB  . GLU B 1 66  ? 122.910 85.999  98.452  1.00 79.31  ? 66  GLU B CB  1 
ATOM 4916 C CG  . GLU B 1 66  ? 122.888 85.774  96.948  1.00 82.38  ? 66  GLU B CG  1 
ATOM 4917 C CD  . GLU B 1 66  ? 123.226 84.346  96.560  1.00 80.66  ? 66  GLU B CD  1 
ATOM 4918 O OE1 . GLU B 1 66  ? 123.089 83.446  97.414  1.00 80.62  ? 66  GLU B OE1 1 
ATOM 4919 O OE2 . GLU B 1 66  ? 123.631 84.125  95.399  1.00 84.91  ? 66  GLU B OE2 1 
ATOM 4920 N N   . THR B 1 67  ? 124.006 86.331  101.465 1.00 76.79  ? 67  THR B N   1 
ATOM 4921 C CA  . THR B 1 67  ? 123.900 87.052  102.732 1.00 80.49  ? 67  THR B CA  1 
ATOM 4922 C C   . THR B 1 67  ? 124.915 86.491  103.718 1.00 78.72  ? 67  THR B C   1 
ATOM 4923 O O   . THR B 1 67  ? 124.620 85.533  104.451 1.00 77.27  ? 67  THR B O   1 
ATOM 4924 C CB  . THR B 1 67  ? 122.486 86.961  103.300 1.00 76.54  ? 67  THR B CB  1 
ATOM 4925 O OG1 . THR B 1 67  ? 121.936 85.670  103.009 1.00 78.00  ? 67  THR B OG1 1 
ATOM 4926 C CG2 . THR B 1 67  ? 121.602 88.034  102.690 1.00 74.36  ? 67  THR B CG2 1 
ATOM 4927 N N   . PRO B 1 68  ? 126.122 87.055  103.776 1.00 76.08  ? 68  PRO B N   1 
ATOM 4928 C CA  . PRO B 1 68  ? 127.089 86.616  104.790 1.00 75.63  ? 68  PRO B CA  1 
ATOM 4929 C C   . PRO B 1 68  ? 126.718 87.140  106.167 1.00 71.91  ? 68  PRO B C   1 
ATOM 4930 O O   . PRO B 1 68  ? 127.294 88.126  106.638 1.00 71.35  ? 68  PRO B O   1 
ATOM 4931 C CB  . PRO B 1 68  ? 128.417 87.206  104.302 1.00 75.73  ? 68  PRO B CB  1 
ATOM 4932 C CG  . PRO B 1 68  ? 128.047 88.332  103.407 1.00 76.39  ? 68  PRO B CG  1 
ATOM 4933 C CD  . PRO B 1 68  ? 126.659 88.104  102.891 1.00 74.81  ? 68  PRO B CD  1 
ATOM 4934 N N   . ALA B 1 69  ? 125.756 86.493  106.819 1.00 49.49  ? 69  ALA B N   1 
ATOM 4935 C CA  . ALA B 1 69  ? 125.230 86.952  108.101 1.00 49.49  ? 69  ALA B CA  1 
ATOM 4936 C C   . ALA B 1 69  ? 125.264 85.794  109.091 1.00 50.43  ? 69  ALA B C   1 
ATOM 4937 O O   . ALA B 1 69  ? 124.436 84.882  109.019 1.00 59.04  ? 69  ALA B O   1 
ATOM 4938 C CB  . ALA B 1 69  ? 123.817 87.502  107.945 1.00 55.64  ? 69  ALA B CB  1 
ATOM 4939 N N   . ASN B 1 70  ? 126.238 85.823  109.997 1.00 46.68  ? 70  ASN B N   1 
ATOM 4940 C CA  . ASN B 1 70  ? 126.326 84.923  111.139 1.00 48.19  ? 70  ASN B CA  1 
ATOM 4941 C C   . ASN B 1 70  ? 126.873 85.720  112.315 1.00 52.14  ? 70  ASN B C   1 
ATOM 4942 O O   . ASN B 1 70  ? 126.992 86.945  112.256 0.15 53.22  ? 70  ASN B O   1 
ATOM 4943 C CB  . ASN B 1 70  ? 127.232 83.711  110.867 1.00 54.62  ? 70  ASN B CB  1 
ATOM 4944 C CG  . ASN B 1 70  ? 126.927 83.012  109.553 1.00 53.69  ? 70  ASN B CG  1 
ATOM 4945 O OD1 . ASN B 1 70  ? 126.274 81.968  109.527 1.00 55.77  ? 70  ASN B OD1 1 
ATOM 4946 N ND2 . ASN B 1 70  ? 127.443 83.558  108.461 1.00 53.24  ? 70  ASN B ND2 1 
ATOM 4947 N N   . GLY B 1 71  ? 127.215 85.021  113.397 1.00 57.96  ? 71  GLY B N   1 
ATOM 4948 C CA  . GLY B 1 71  ? 128.013 85.653  114.433 1.00 62.67  ? 71  GLY B CA  1 
ATOM 4949 C C   . GLY B 1 71  ? 129.494 85.674  114.136 1.00 60.56  ? 71  GLY B C   1 
ATOM 4950 O O   . GLY B 1 71  ? 130.198 86.590  114.582 1.00 55.85  ? 71  GLY B O   1 
ATOM 4951 N N   . TYR B 1 72  ? 129.973 84.690  113.374 1.00 52.31  ? 72  TYR B N   1 
ATOM 4952 C CA  . TYR B 1 72  ? 131.396 84.580  113.084 1.00 57.86  ? 72  TYR B CA  1 
ATOM 4953 C C   . TYR B 1 72  ? 131.869 85.719  112.191 1.00 56.59  ? 72  TYR B C   1 
ATOM 4954 O O   . TYR B 1 72  ? 132.932 86.306  112.433 1.00 56.93  ? 72  TYR B O   1 
ATOM 4955 C CB  . TYR B 1 72  ? 131.682 83.224  112.446 1.00 61.00  ? 72  TYR B CB  1 
ATOM 4956 C CG  . TYR B 1 72  ? 131.196 82.068  113.280 1.00 54.70  ? 72  TYR B CG  1 
ATOM 4957 C CD1 . TYR B 1 72  ? 131.527 81.978  114.624 1.00 56.86  ? 72  TYR B CD1 1 
ATOM 4958 C CD2 . TYR B 1 72  ? 130.404 81.073  112.732 1.00 60.44  ? 72  TYR B CD2 1 
ATOM 4959 C CE1 . TYR B 1 72  ? 131.089 80.928  115.400 1.00 60.28  ? 72  TYR B CE1 1 
ATOM 4960 C CE2 . TYR B 1 72  ? 129.957 80.016  113.501 1.00 67.08  ? 72  TYR B CE2 1 
ATOM 4961 C CZ  . TYR B 1 72  ? 130.304 79.950  114.836 1.00 63.15  ? 72  TYR B CZ  1 
ATOM 4962 O OH  . TYR B 1 72  ? 129.866 78.903  115.615 1.00 57.15  ? 72  TYR B OH  1 
ATOM 4963 N N   . ARG B 1 73  ? 131.086 86.052  111.159 1.00 44.09  ? 73  ARG B N   1 
ATOM 4964 C CA  . ARG B 1 73  ? 131.419 87.191  110.311 1.00 48.58  ? 73  ARG B CA  1 
ATOM 4965 C C   . ARG B 1 73  ? 131.416 88.490  111.100 1.00 44.65  ? 73  ARG B C   1 
ATOM 4966 O O   . ARG B 1 73  ? 132.253 89.363  110.852 1.00 52.36  ? 73  ARG B O   1 
ATOM 4967 C CB  . ARG B 1 73  ? 130.440 87.296  109.143 1.00 48.76  ? 73  ARG B CB  1 
ATOM 4968 C CG  . ARG B 1 73  ? 130.107 85.978  108.484 1.00 54.47  ? 73  ARG B CG  1 
ATOM 4969 C CD  . ARG B 1 73  ? 131.154 85.590  107.469 1.00 53.43  ? 73  ARG B CD  1 
ATOM 4970 N NE  . ARG B 1 73  ? 130.795 84.356  106.783 1.00 64.33  ? 73  ARG B NE  1 
ATOM 4971 C CZ  . ARG B 1 73  ? 130.767 84.207  105.467 1.00 63.46  ? 73  ARG B CZ  1 
ATOM 4972 N NH1 . ARG B 1 73  ? 131.094 85.197  104.653 1.00 59.75  ? 73  ARG B NH1 1 
ATOM 4973 N NH2 . ARG B 1 73  ? 130.415 83.032  104.954 1.00 59.27  ? 73  ARG B NH2 1 
ATOM 4974 N N   . SER B 1 74  ? 130.516 88.618  112.075 1.00 36.67  ? 74  SER B N   1 
ATOM 4975 C CA  . SER B 1 74  ? 130.443 89.850  112.851 1.00 45.94  ? 74  SER B CA  1 
ATOM 4976 C C   . SER B 1 74  ? 131.635 89.990  113.795 1.00 52.12  ? 74  SER B C   1 
ATOM 4977 O O   . SER B 1 74  ? 132.203 91.083  113.924 1.00 60.16  ? 74  SER B O   1 
ATOM 4978 C CB  . SER B 1 74  ? 129.125 89.898  113.618 1.00 47.74  ? 74  SER B CB  1 
ATOM 4979 O OG  . SER B 1 74  ? 128.930 91.170  114.203 1.00 52.28  ? 74  SER B OG  1 
ATOM 4980 N N   . LEU B 1 75  ? 132.045 88.898  114.452 1.00 46.08  ? 75  LEU B N   1 
ATOM 4981 C CA  . LEU B 1 75  ? 133.223 88.973  115.317 1.00 49.95  ? 75  LEU B CA  1 
ATOM 4982 C C   . LEU B 1 75  ? 134.499 89.187  114.507 1.00 46.52  ? 75  LEU B C   1 
ATOM 4983 O O   . LEU B 1 75  ? 135.397 89.932  114.934 1.00 42.38  ? 75  LEU B O   1 
ATOM 4984 C CB  . LEU B 1 75  ? 133.334 87.714  116.174 1.00 46.30  ? 75  LEU B CB  1 
ATOM 4985 C CG  . LEU B 1 75  ? 133.755 87.965  117.624 1.00 42.93  ? 75  LEU B CG  1 
ATOM 4986 C CD1 . LEU B 1 75  ? 132.848 88.987  118.287 1.00 36.62  ? 75  LEU B CD1 1 
ATOM 4987 C CD2 . LEU B 1 75  ? 133.767 86.670  118.411 1.00 45.76  ? 75  LEU B CD2 1 
ATOM 4988 N N   . VAL B 1 76  ? 134.590 88.557  113.331 1.00 47.92  ? 76  VAL B N   1 
ATOM 4989 C CA  . VAL B 1 76  ? 135.727 88.770  112.441 1.00 43.54  ? 76  VAL B CA  1 
ATOM 4990 C C   . VAL B 1 76  ? 135.783 90.224  111.985 1.00 42.81  ? 76  VAL B C   1 
ATOM 4991 O O   . VAL B 1 76  ? 136.858 90.835  111.953 1.00 45.14  ? 76  VAL B O   1 
ATOM 4992 C CB  . VAL B 1 76  ? 135.651 87.789  111.253 1.00 47.39  ? 76  VAL B CB  1 
ATOM 4993 C CG1 . VAL B 1 76  ? 136.388 88.320  110.028 1.00 50.17  ? 76  VAL B CG1 1 
ATOM 4994 C CG2 . VAL B 1 76  ? 136.194 86.427  111.658 1.00 40.63  ? 76  VAL B CG2 1 
ATOM 4995 N N   . HIS B 1 77  ? 134.626 90.808  111.653 1.00 38.53  ? 77  HIS B N   1 
ATOM 4996 C CA  . HIS B 1 77  ? 134.581 92.210  111.247 1.00 38.80  ? 77  HIS B CA  1 
ATOM 4997 C C   . HIS B 1 77  ? 134.968 93.141  112.388 1.00 40.27  ? 77  HIS B C   1 
ATOM 4998 O O   . HIS B 1 77  ? 135.641 94.151  112.160 1.00 43.91  ? 77  HIS B O   1 
ATOM 4999 C CB  . HIS B 1 77  ? 133.192 92.563  110.725 1.00 48.12  ? 77  HIS B CB  1 
ATOM 5000 C CG  . HIS B 1 77  ? 133.016 92.298  109.264 1.00 51.58  ? 77  HIS B CG  1 
ATOM 5001 N ND1 . HIS B 1 77  ? 133.232 91.059  108.702 1.00 44.80  ? 77  HIS B ND1 1 
ATOM 5002 C CD2 . HIS B 1 77  ? 132.637 93.112  108.251 1.00 49.63  ? 77  HIS B CD2 1 
ATOM 5003 C CE1 . HIS B 1 77  ? 132.998 91.121  107.403 1.00 49.00  ? 77  HIS B CE1 1 
ATOM 5004 N NE2 . HIS B 1 77  ? 132.635 92.355  107.104 1.00 51.36  ? 77  HIS B NE2 1 
ATOM 5005 N N   . THR B 1 78  ? 134.555 92.822  113.619 1.00 24.88  ? 78  THR B N   1 
ATOM 5006 C CA  . THR B 1 78  ? 134.942 93.646  114.763 1.00 34.75  ? 78  THR B CA  1 
ATOM 5007 C C   . THR B 1 78  ? 136.454 93.616  114.991 1.00 50.32  ? 78  THR B C   1 
ATOM 5008 O O   . THR B 1 78  ? 137.086 94.668  115.187 1.00 52.33  ? 78  THR B O   1 
ATOM 5009 C CB  . THR B 1 78  ? 134.194 93.180  116.011 1.00 33.35  ? 78  THR B CB  1 
ATOM 5010 O OG1 . THR B 1 78  ? 132.817 92.967  115.685 1.00 43.27  ? 78  THR B OG1 1 
ATOM 5011 C CG2 . THR B 1 78  ? 134.280 94.218  117.107 1.00 36.00  ? 78  THR B CG2 1 
ATOM 5012 N N   . ALA B 1 79  ? 137.056 92.421  114.934 1.00 40.55  ? 79  ALA B N   1 
ATOM 5013 C CA  . ALA B 1 79  ? 138.504 92.313  115.100 1.00 29.89  ? 79  ALA B CA  1 
ATOM 5014 C C   . ALA B 1 79  ? 139.254 93.001  113.964 1.00 33.02  ? 79  ALA B C   1 
ATOM 5015 O O   . ALA B 1 79  ? 140.263 93.681  114.198 1.00 39.65  ? 79  ALA B O   1 
ATOM 5016 C CB  . ALA B 1 79  ? 138.913 90.846  115.201 1.00 37.89  ? 79  ALA B CB  1 
ATOM 5017 N N   . ARG B 1 80  ? 138.768 92.848  112.731 1.00 38.92  ? 80  ARG B N   1 
ATOM 5018 C CA  . ARG B 1 80  ? 139.408 93.486  111.586 1.00 43.81  ? 80  ARG B CA  1 
ATOM 5019 C C   . ARG B 1 80  ? 139.312 95.004  111.670 1.00 38.82  ? 80  ARG B C   1 
ATOM 5020 O O   . ARG B 1 80  ? 140.263 95.708  111.316 1.00 42.44  ? 80  ARG B O   1 
ATOM 5021 C CB  . ARG B 1 80  ? 138.785 92.965  110.289 1.00 44.32  ? 80  ARG B CB  1 
ATOM 5022 C CG  . ARG B 1 80  ? 139.055 93.814  109.054 1.00 44.91  ? 80  ARG B CG  1 
ATOM 5023 C CD  . ARG B 1 80  ? 139.247 92.958  107.810 1.00 47.69  ? 80  ARG B CD  1 
ATOM 5024 N NE  . ARG B 1 80  ? 138.357 91.803  107.778 1.00 45.86  ? 80  ARG B NE  1 
ATOM 5025 C CZ  . ARG B 1 80  ? 137.077 91.849  107.436 1.00 45.78  ? 80  ARG B CZ  1 
ATOM 5026 N NH1 . ARG B 1 80  ? 136.501 92.980  107.061 1.00 35.48  ? 80  ARG B NH1 1 
ATOM 5027 N NH2 . ARG B 1 80  ? 136.358 90.731  107.464 1.00 50.79  ? 80  ARG B NH2 1 
ATOM 5028 N N   . CYS B 1 81  ? 138.183 95.529  112.153 1.00 39.71  ? 81  CYS B N   1 
ATOM 5029 C CA  . CYS B 1 81  ? 138.045 96.976  112.261 1.00 34.01  ? 81  CYS B CA  1 
ATOM 5030 C C   . CYS B 1 81  ? 138.956 97.536  113.348 1.00 42.41  ? 81  CYS B C   1 
ATOM 5031 O O   . CYS B 1 81  ? 139.553 98.608  113.172 1.00 58.25  ? 81  CYS B O   1 
ATOM 5032 C CB  . CYS B 1 81  ? 136.585 97.348  112.516 1.00 37.98  ? 81  CYS B CB  1 
ATOM 5033 S SG  . CYS B 1 81  ? 136.320 99.071  112.963 1.00 61.57  ? 81  CYS B SG  1 
ATOM 5034 N N   . CYS B 1 82  ? 139.099 96.813  114.468 1.00 35.72  ? 82  CYS B N   1 
ATOM 5035 C CA  . CYS B 1 82  ? 140.064 97.225  115.493 1.00 49.26  ? 82  CYS B CA  1 
ATOM 5036 C C   . CYS B 1 82  ? 141.494 97.219  114.952 1.00 43.21  ? 82  CYS B C   1 
ATOM 5037 O O   . CYS B 1 82  ? 142.272 98.152  115.210 1.00 36.31  ? 82  CYS B O   1 
ATOM 5038 C CB  . CYS B 1 82  ? 139.955 96.314  116.717 1.00 46.23  ? 82  CYS B CB  1 
ATOM 5039 S SG  . CYS B 1 82  ? 140.247 97.120  118.309 1.00 16.23  ? 82  CYS B SG  1 
ATOM 5040 N N   . LEU B 1 83  ? 141.851 96.181  114.185 1.00 44.07  ? 83  LEU B N   1 
ATOM 5041 C CA  . LEU B 1 83  ? 143.191 96.103  113.608 1.00 35.38  ? 83  LEU B CA  1 
ATOM 5042 C C   . LEU B 1 83  ? 143.437 97.215  112.593 1.00 41.08  ? 83  LEU B C   1 
ATOM 5043 O O   . LEU B 1 83  ? 144.534 97.779  112.545 1.00 52.31  ? 83  LEU B O   1 
ATOM 5044 C CB  . LEU B 1 83  ? 143.408 94.735  112.965 1.00 35.18  ? 83  LEU B CB  1 
ATOM 5045 C CG  . LEU B 1 83  ? 143.753 93.601  113.931 1.00 38.22  ? 83  LEU B CG  1 
ATOM 5046 C CD1 . LEU B 1 83  ? 144.052 92.320  113.172 1.00 41.61  ? 83  LEU B CD1 1 
ATOM 5047 C CD2 . LEU B 1 83  ? 144.929 93.991  114.807 1.00 42.61  ? 83  LEU B CD2 1 
ATOM 5048 N N   . ALA B 1 84  ? 142.432 97.546  111.778 1.00 39.96  ? 84  ALA B N   1 
ATOM 5049 C CA  . ALA B 1 84  ? 142.594 98.618  110.798 1.00 41.82  ? 84  ALA B CA  1 
ATOM 5050 C C   . ALA B 1 84  ? 142.721 99.977  111.476 1.00 41.25  ? 84  ALA B C   1 
ATOM 5051 O O   . ALA B 1 84  ? 143.489 100.835 111.020 1.00 44.66  ? 84  ALA B O   1 
ATOM 5052 C CB  . ALA B 1 84  ? 141.424 98.617  109.816 1.00 40.06  ? 84  ALA B CB  1 
ATOM 5053 N N   . HIS B 1 85  ? 141.977 100.189 112.567 1.00 40.79  ? 85  HIS B N   1 
ATOM 5054 C CA  . HIS B 1 85  ? 142.107 101.425 113.334 1.00 43.50  ? 85  HIS B CA  1 
ATOM 5055 C C   . HIS B 1 85  ? 143.504 101.564 113.931 1.00 43.59  ? 85  HIS B C   1 
ATOM 5056 O O   . HIS B 1 85  ? 144.123 102.637 113.847 1.00 44.06  ? 85  HIS B O   1 
ATOM 5057 C CB  . HIS B 1 85  ? 141.048 101.453 114.436 1.00 37.94  ? 85  HIS B CB  1 
ATOM 5058 C CG  . HIS B 1 85  ? 139.859 102.303 114.117 1.00 42.94  ? 85  HIS B CG  1 
ATOM 5059 N ND1 . HIS B 1 85  ? 139.710 103.585 114.599 1.00 53.89  ? 85  HIS B ND1 1 
ATOM 5060 C CD2 . HIS B 1 85  ? 138.766 102.057 113.357 1.00 41.83  ? 85  HIS B CD2 1 
ATOM 5061 C CE1 . HIS B 1 85  ? 138.573 104.089 114.156 1.00 57.26  ? 85  HIS B CE1 1 
ATOM 5062 N NE2 . HIS B 1 85  ? 137.981 103.183 113.399 1.00 50.97  ? 85  HIS B NE2 1 
ATOM 5063 N N   . LEU B 1 86  ? 144.026 100.481 114.517 1.00 45.93  ? 86  LEU B N   1 
ATOM 5064 C CA  . LEU B 1 86  ? 145.376 100.521 115.075 1.00 43.47  ? 86  LEU B CA  1 
ATOM 5065 C C   . LEU B 1 86  ? 146.427 100.706 113.985 1.00 47.51  ? 86  LEU B C   1 
ATOM 5066 O O   . LEU B 1 86  ? 147.430 101.395 114.197 1.00 49.29  ? 86  LEU B O   1 
ATOM 5067 C CB  . LEU B 1 86  ? 145.650 99.251  115.877 1.00 46.85  ? 86  LEU B CB  1 
ATOM 5068 C CG  . LEU B 1 86  ? 146.407 99.400  117.196 1.00 39.98  ? 86  LEU B CG  1 
ATOM 5069 C CD1 . LEU B 1 86  ? 146.090 100.722 117.868 1.00 45.81  ? 86  LEU B CD1 1 
ATOM 5070 C CD2 . LEU B 1 86  ? 146.065 98.244  118.120 1.00 43.93  ? 86  LEU B CD2 1 
ATOM 5071 N N   . LEU B 1 87  ? 146.203 100.111 112.810 1.00 57.54  ? 87  LEU B N   1 
ATOM 5072 C CA  . LEU B 1 87  ? 147.127 100.270 111.691 1.00 53.73  ? 87  LEU B CA  1 
ATOM 5073 C C   . LEU B 1 87  ? 147.174 101.713 111.205 1.00 59.26  ? 87  LEU B C   1 
ATOM 5074 O O   . LEU B 1 87  ? 148.255 102.254 110.943 1.00 58.50  ? 87  LEU B O   1 
ATOM 5075 C CB  . LEU B 1 87  ? 146.724 99.336  110.551 1.00 57.04  ? 87  LEU B CB  1 
ATOM 5076 C CG  . LEU B 1 87  ? 147.735 99.133  109.423 1.00 57.88  ? 87  LEU B CG  1 
ATOM 5077 C CD1 . LEU B 1 87  ? 147.903 97.655  109.137 1.00 62.94  ? 87  LEU B CD1 1 
ATOM 5078 C CD2 . LEU B 1 87  ? 147.291 99.874  108.172 1.00 58.59  ? 87  LEU B CD2 1 
ATOM 5079 N N   . HIS B 1 88  ? 146.008 102.353 111.070 1.00 57.59  ? 88  HIS B N   1 
ATOM 5080 C CA  . HIS B 1 88  ? 145.978 103.746 110.628 1.00 58.05  ? 88  HIS B CA  1 
ATOM 5081 C C   . HIS B 1 88  ? 146.616 104.671 111.659 1.00 56.95  ? 88  HIS B C   1 
ATOM 5082 O O   . HIS B 1 88  ? 147.350 105.602 111.294 1.00 58.85  ? 88  HIS B O   1 
ATOM 5083 C CB  . HIS B 1 88  ? 144.544 104.179 110.335 1.00 57.90  ? 88  HIS B CB  1 
ATOM 5084 C CG  . HIS B 1 88  ? 144.361 105.663 110.284 1.00 54.70  ? 88  HIS B CG  1 
ATOM 5085 N ND1 . HIS B 1 88  ? 143.934 106.398 111.369 1.00 58.19  ? 88  HIS B ND1 1 
ATOM 5086 C CD2 . HIS B 1 88  ? 144.552 106.551 109.281 1.00 58.23  ? 88  HIS B CD2 1 
ATOM 5087 C CE1 . HIS B 1 88  ? 143.866 107.674 111.035 1.00 61.24  ? 88  HIS B CE1 1 
ATOM 5088 N NE2 . HIS B 1 88  ? 144.236 107.794 109.773 1.00 60.38  ? 88  HIS B NE2 1 
ATOM 5089 N N   . LYS B 1 89  ? 146.354 104.427 112.950 1.00 58.77  ? 89  LYS B N   1 
ATOM 5090 C CA  . LYS B 1 89  ? 146.986 105.231 113.994 1.00 58.00  ? 89  LYS B CA  1 
ATOM 5091 C C   . LYS B 1 89  ? 148.501 105.054 113.996 1.00 57.75  ? 89  LYS B C   1 
ATOM 5092 O O   . LYS B 1 89  ? 149.245 106.029 114.153 1.00 63.00  ? 89  LYS B O   1 
ATOM 5093 C CB  . LYS B 1 89  ? 146.405 104.874 115.360 1.00 61.39  ? 89  LYS B CB  1 
ATOM 5094 C CG  . LYS B 1 89  ? 145.008 105.420 115.610 1.00 69.92  ? 89  LYS B CG  1 
ATOM 5095 C CD  . LYS B 1 89  ? 144.887 106.881 115.207 1.00 65.81  ? 89  LYS B CD  1 
ATOM 5096 C CE  . LYS B 1 89  ? 143.431 107.321 115.174 1.00 64.01  ? 89  LYS B CE  1 
ATOM 5097 N NZ  . LYS B 1 89  ? 142.650 106.602 114.131 1.00 62.34  ? 89  LYS B NZ  1 
ATOM 5098 N N   . SER B 1 90  ? 148.976 103.818 113.805 1.00 65.28  ? 90  SER B N   1 
ATOM 5099 C CA  . SER B 1 90  ? 150.413 103.573 113.741 1.00 65.76  ? 90  SER B CA  1 
ATOM 5100 C C   . SER B 1 90  ? 151.042 104.234 112.520 1.00 65.27  ? 90  SER B C   1 
ATOM 5101 O O   . SER B 1 90  ? 152.156 104.758 112.608 1.00 67.88  ? 90  SER B O   1 
ATOM 5102 C CB  . SER B 1 90  ? 150.692 102.072 113.735 1.00 68.98  ? 90  SER B CB  1 
ATOM 5103 O OG  . SER B 1 90  ? 152.076 101.817 113.582 1.00 63.46  ? 90  SER B OG  1 
ATOM 5104 N N   . ARG B 1 91  ? 150.346 104.214 111.377 1.00 75.15  ? 91  ARG B N   1 
ATOM 5105 C CA  . ARG B 1 91  ? 150.851 104.871 110.172 1.00 77.58  ? 91  ARG B CA  1 
ATOM 5106 C C   . ARG B 1 91  ? 150.993 106.375 110.383 1.00 81.61  ? 91  ARG B C   1 
ATOM 5107 O O   . ARG B 1 91  ? 152.021 106.971 110.032 1.00 78.27  ? 91  ARG B O   1 
ATOM 5108 C CB  . ARG B 1 91  ? 149.918 104.592 108.991 1.00 71.54  ? 91  ARG B CB  1 
ATOM 5109 C CG  . ARG B 1 91  ? 150.060 103.213 108.377 1.00 77.13  ? 91  ARG B CG  1 
ATOM 5110 C CD  . ARG B 1 91  ? 151.396 103.042 107.686 1.00 81.44  ? 91  ARG B CD  1 
ATOM 5111 N NE  . ARG B 1 91  ? 151.382 101.915 106.761 1.00 82.38  ? 91  ARG B NE  1 
ATOM 5112 C CZ  . ARG B 1 91  ? 152.465 101.276 106.342 1.00 77.11  ? 91  ARG B CZ  1 
ATOM 5113 N NH1 . ARG B 1 91  ? 153.675 101.631 106.743 1.00 76.92  ? 91  ARG B NH1 1 
ATOM 5114 N NH2 . ARG B 1 91  ? 152.332 100.257 105.499 1.00 79.29  ? 91  ARG B NH2 1 
ATOM 5115 N N   . TYR B 1 92  ? 149.971 106.998 110.980 1.00 77.14  ? 92  TYR B N   1 
ATOM 5116 C CA  . TYR B 1 92  ? 150.016 108.435 111.246 1.00 74.74  ? 92  TYR B CA  1 
ATOM 5117 C C   . TYR B 1 92  ? 151.114 108.790 112.245 1.00 73.01  ? 92  TYR B C   1 
ATOM 5118 O O   . TYR B 1 92  ? 151.838 109.775 112.052 1.00 78.41  ? 92  TYR B O   1 
ATOM 5119 C CB  . TYR B 1 92  ? 148.655 108.907 111.756 1.00 77.43  ? 92  TYR B CB  1 
ATOM 5120 C CG  . TYR B 1 92  ? 148.269 110.307 111.337 1.00 79.21  ? 92  TYR B CG  1 
ATOM 5121 C CD1 . TYR B 1 92  ? 147.666 110.543 110.107 1.00 77.48  ? 92  TYR B CD1 1 
ATOM 5122 C CD2 . TYR B 1 92  ? 148.490 111.389 112.179 1.00 80.36  ? 92  TYR B CD2 1 
ATOM 5123 C CE1 . TYR B 1 92  ? 147.302 111.819 109.724 1.00 77.68  ? 92  TYR B CE1 1 
ATOM 5124 C CE2 . TYR B 1 92  ? 148.131 112.669 111.806 1.00 84.32  ? 92  TYR B CE2 1 
ATOM 5125 C CZ  . TYR B 1 92  ? 147.538 112.878 110.578 1.00 83.06  ? 92  TYR B CZ  1 
ATOM 5126 O OH  . TYR B 1 92  ? 147.179 114.153 110.203 1.00 79.47  ? 92  TYR B OH  1 
ATOM 5127 N N   . VAL B 1 93  ? 151.263 107.997 113.310 1.00 76.09  ? 93  VAL B N   1 
ATOM 5128 C CA  . VAL B 1 93  ? 152.279 108.295 114.317 1.00 78.36  ? 93  VAL B CA  1 
ATOM 5129 C C   . VAL B 1 93  ? 153.681 108.086 113.751 1.00 78.82  ? 93  VAL B C   1 
ATOM 5130 O O   . VAL B 1 93  ? 154.591 108.881 114.013 1.00 79.16  ? 93  VAL B O   1 
ATOM 5131 C CB  . VAL B 1 93  ? 152.028 107.459 115.587 1.00 79.48  ? 93  VAL B CB  1 
ATOM 5132 C CG1 . VAL B 1 93  ? 153.193 107.565 116.564 1.00 75.27  ? 93  VAL B CG1 1 
ATOM 5133 C CG2 . VAL B 1 93  ? 150.759 107.928 116.264 1.00 78.68  ? 93  VAL B CG2 1 
ATOM 5134 N N   . ALA B 1 94  ? 153.873 107.037 112.946 1.00 78.26  ? 94  ALA B N   1 
ATOM 5135 C CA  . ALA B 1 94  ? 155.173 106.801 112.325 1.00 80.09  ? 94  ALA B CA  1 
ATOM 5136 C C   . ALA B 1 94  ? 155.528 107.902 111.334 1.00 83.30  ? 94  ALA B C   1 
ATOM 5137 O O   . ALA B 1 94  ? 156.689 108.321 111.256 1.00 81.93  ? 94  ALA B O   1 
ATOM 5138 C CB  . ALA B 1 94  ? 155.186 105.435 111.638 1.00 79.06  ? 94  ALA B CB  1 
ATOM 5139 N N   . SER B 1 95  ? 154.548 108.389 110.571 1.00 84.66  ? 95  SER B N   1 
ATOM 5140 C CA  . SER B 1 95  ? 154.810 109.493 109.659 1.00 84.55  ? 95  SER B CA  1 
ATOM 5141 C C   . SER B 1 95  ? 154.955 110.835 110.367 1.00 88.76  ? 95  SER B C   1 
ATOM 5142 O O   . SER B 1 95  ? 155.502 111.769 109.772 1.00 83.73  ? 95  SER B O   1 
ATOM 5143 C CB  . SER B 1 95  ? 153.696 109.589 108.613 1.00 85.44  ? 95  SER B CB  1 
ATOM 5144 O OG  . SER B 1 95  ? 153.731 110.839 107.946 1.00 86.72  ? 95  SER B OG  1 
ATOM 5145 N N   . ASN B 1 96  ? 154.491 110.957 111.611 1.00 90.42  ? 96  ASN B N   1 
ATOM 5146 C CA  . ASN B 1 96  ? 154.493 112.230 112.330 1.00 85.35  ? 96  ASN B CA  1 
ATOM 5147 C C   . ASN B 1 96  ? 155.182 112.095 113.686 1.00 83.71  ? 96  ASN B C   1 
ATOM 5148 O O   . ASN B 1 96  ? 154.664 112.530 114.717 1.00 81.44  ? 96  ASN B O   1 
ATOM 5149 C CB  . ASN B 1 96  ? 153.069 112.750 112.509 1.00 82.46  ? 96  ASN B CB  1 
ATOM 5150 C CG  . ASN B 1 96  ? 152.555 113.483 111.285 1.00 81.32  ? 96  ASN B CG  1 
ATOM 5151 O OD1 . ASN B 1 96  ? 153.111 113.364 110.194 1.00 82.37  ? 96  ASN B OD1 1 
ATOM 5152 N ND2 . ASN B 1 96  ? 151.482 114.244 111.461 1.00 80.62  ? 96  ASN B ND2 1 
ATOM 5153 N N   . ARG B 1 97  ? 156.368 111.490 113.707 1.00 88.95  ? 97  ARG B N   1 
ATOM 5154 C CA  . ARG B 1 97  ? 157.159 111.361 114.928 1.00 89.62  ? 97  ARG B CA  1 
ATOM 5155 C C   . ARG B 1 97  ? 158.504 112.067 114.788 1.00 91.93  ? 97  ARG B C   1 
ATOM 5156 O O   . ARG B 1 97  ? 159.524 111.614 115.311 1.00 89.06  ? 97  ARG B O   1 
ATOM 5157 C CB  . ARG B 1 97  ? 157.363 109.894 115.304 1.00 89.37  ? 97  ARG B CB  1 
ATOM 5158 C CG  . ARG B 1 97  ? 157.430 109.642 116.809 1.00 92.75  ? 97  ARG B CG  1 
ATOM 5159 C CD  . ARG B 1 97  ? 157.738 108.187 117.138 1.00 88.85  ? 97  ARG B CD  1 
ATOM 5160 N NE  . ARG B 1 97  ? 156.673 107.283 116.721 1.00 87.60  ? 97  ARG B NE  1 
ATOM 5161 C CZ  . ARG B 1 97  ? 156.775 106.416 115.723 1.00 87.81  ? 97  ARG B CZ  1 
ATOM 5162 N NH1 . ARG B 1 97  ? 157.880 106.318 115.003 1.00 92.83  ? 97  ARG B NH1 1 
ATOM 5163 N NH2 . ARG B 1 97  ? 155.743 105.626 115.442 1.00 87.99  ? 97  ARG B NH2 1 
ATOM 5164 N N   . ARG B 1 98  ? 158.522 113.190 114.070 1.00 91.81  ? 98  ARG B N   1 
ATOM 5165 C CA  . ARG B 1 98  ? 159.759 113.952 113.937 1.00 92.00  ? 98  ARG B CA  1 
ATOM 5166 C C   . ARG B 1 98  ? 160.074 114.733 115.207 1.00 94.31  ? 98  ARG B C   1 
ATOM 5167 O O   . ARG B 1 98  ? 161.245 114.881 115.574 1.00 91.63  ? 98  ARG B O   1 
ATOM 5168 C CB  . ARG B 1 98  ? 159.671 114.894 112.736 1.00 92.05  ? 98  ARG B CB  1 
ATOM 5169 C CG  . ARG B 1 98  ? 159.607 114.176 111.399 1.00 90.66  ? 98  ARG B CG  1 
ATOM 5170 C CD  . ARG B 1 98  ? 160.995 113.777 110.928 1.00 89.05  ? 98  ARG B CD  1 
ATOM 5171 N NE  . ARG B 1 98  ? 160.970 112.571 110.108 1.00 93.47  ? 98  ARG B NE  1 
ATOM 5172 C CZ  . ARG B 1 98  ? 161.893 111.620 110.149 1.00 94.48  ? 98  ARG B CZ  1 
ATOM 5173 N NH1 . ARG B 1 98  ? 162.932 111.699 110.964 1.00 94.94  ? 98  ARG B NH1 1 
ATOM 5174 N NH2 . ARG B 1 98  ? 161.770 110.562 109.352 1.00 92.09  ? 98  ARG B NH2 1 
ATOM 5175 N N   . SER B 1 99  ? 159.049 115.230 115.887 1.00 93.03  ? 99  SER B N   1 
ATOM 5176 C CA  . SER B 1 99  ? 159.195 115.971 117.131 1.00 98.03  ? 99  SER B CA  1 
ATOM 5177 C C   . SER B 1 99  ? 158.379 115.290 118.227 1.00 98.78  ? 99  SER B C   1 
ATOM 5178 O O   . SER B 1 99  ? 157.680 114.302 117.992 1.00 92.82  ? 99  SER B O   1 
ATOM 5179 C CB  . SER B 1 99  ? 158.767 117.430 116.949 0.19 93.01  ? 99  SER B CB  1 
ATOM 5180 O OG  . SER B 1 99  ? 158.759 118.119 118.187 1.00 93.00  ? 99  SER B OG  1 
ATOM 5181 N N   . ILE B 1 100 ? 158.477 115.832 119.439 1.00 95.76  ? 100 ILE B N   1 
ATOM 5182 C CA  . ILE B 1 100 ? 157.743 115.315 120.590 1.00 90.81  ? 100 ILE B CA  1 
ATOM 5183 C C   . ILE B 1 100 ? 156.749 116.412 120.965 1.00 87.92  ? 100 ILE B C   1 
ATOM 5184 O O   . ILE B 1 100 ? 156.452 116.642 122.144 1.00 86.60  ? 100 ILE B O   1 
ATOM 5185 C CB  . ILE B 1 100 ? 158.681 114.938 121.760 1.00 89.51  ? 100 ILE B CB  1 
ATOM 5186 C CG1 . ILE B 1 100 ? 159.916 114.159 121.290 1.00 88.69  ? 100 ILE B CG1 1 
ATOM 5187 C CG2 . ILE B 1 100 ? 157.988 113.981 122.734 1.00 91.48  ? 100 ILE B CG2 1 
ATOM 5188 C CD1 . ILE B 1 100 ? 159.633 112.937 120.414 1.00 89.08  ? 100 ILE B CD1 1 
ATOM 5189 N N   . PHE B 1 101 ? 156.267 117.134 119.948 1.00 87.88  ? 101 PHE B N   1 
ATOM 5190 C CA  . PHE B 1 101 ? 155.294 118.198 120.177 1.00 88.81  ? 101 PHE B CA  1 
ATOM 5191 C C   . PHE B 1 101 ? 153.977 117.646 120.710 1.00 88.33  ? 101 PHE B C   1 
ATOM 5192 O O   . PHE B 1 101 ? 153.383 118.220 121.631 1.00 88.83  ? 101 PHE B O   1 
ATOM 5193 C CB  . PHE B 1 101 ? 155.063 118.983 118.885 1.00 87.70  ? 101 PHE B CB  1 
ATOM 5194 C CG  . PHE B 1 101 ? 153.980 120.017 118.990 1.00 87.64  ? 101 PHE B CG  1 
ATOM 5195 C CD1 . PHE B 1 101 ? 154.191 121.189 119.698 1.00 85.28  ? 101 PHE B CD1 1 
ATOM 5196 C CD2 . PHE B 1 101 ? 152.750 119.818 118.379 1.00 87.63  ? 101 PHE B CD2 1 
ATOM 5197 C CE1 . PHE B 1 101 ? 153.196 122.143 119.798 1.00 90.60  ? 101 PHE B CE1 1 
ATOM 5198 C CE2 . PHE B 1 101 ? 151.750 120.768 118.476 1.00 86.69  ? 101 PHE B CE2 1 
ATOM 5199 C CZ  . PHE B 1 101 ? 151.974 121.932 119.187 1.00 89.80  ? 101 PHE B CZ  1 
ATOM 5200 N N   . PHE B 1 102 ? 153.500 116.542 120.138 1.00 86.71  ? 102 PHE B N   1 
ATOM 5201 C CA  . PHE B 1 102 ? 152.304 115.891 120.652 1.00 86.37  ? 102 PHE B CA  1 
ATOM 5202 C C   . PHE B 1 102 ? 152.592 115.286 122.019 1.00 88.80  ? 102 PHE B C   1 
ATOM 5203 O O   . PHE B 1 102 ? 153.667 114.726 122.253 1.00 92.32  ? 102 PHE B O   1 
ATOM 5204 C CB  . PHE B 1 102 ? 151.810 114.811 119.679 1.00 83.38  ? 102 PHE B CB  1 
ATOM 5205 C CG  . PHE B 1 102 ? 152.782 113.675 119.469 1.00 85.54  ? 102 PHE B CG  1 
ATOM 5206 C CD1 . PHE B 1 102 ? 153.816 113.786 118.552 1.00 90.49  ? 102 PHE B CD1 1 
ATOM 5207 C CD2 . PHE B 1 102 ? 152.644 112.488 120.170 1.00 84.73  ? 102 PHE B CD2 1 
ATOM 5208 C CE1 . PHE B 1 102 ? 154.704 112.745 118.356 1.00 87.05  ? 102 PHE B CE1 1 
ATOM 5209 C CE2 . PHE B 1 102 ? 153.530 111.445 119.978 1.00 88.33  ? 102 PHE B CE2 1 
ATOM 5210 C CZ  . PHE B 1 102 ? 154.559 111.575 119.069 1.00 85.85  ? 102 PHE B CZ  1 
ATOM 5211 N N   . ARG B 1 103 ? 151.636 115.420 122.934 1.00 86.04  ? 103 ARG B N   1 
ATOM 5212 C CA  . ARG B 1 103 ? 151.838 114.905 124.280 1.00 83.62  ? 103 ARG B CA  1 
ATOM 5213 C C   . ARG B 1 103 ? 151.741 113.386 124.281 1.00 82.60  ? 103 ARG B C   1 
ATOM 5214 O O   . ARG B 1 103 ? 150.790 112.809 123.746 1.00 81.85  ? 103 ARG B O   1 
ATOM 5215 C CB  . ARG B 1 103 ? 150.826 115.510 125.250 1.00 84.34  ? 103 ARG B CB  1 
ATOM 5216 C CG  . ARG B 1 103 ? 151.477 116.379 126.314 1.00 85.26  ? 103 ARG B CG  1 
ATOM 5217 C CD  . ARG B 1 103 ? 150.511 116.758 127.421 1.00 83.86  ? 103 ARG B CD  1 
ATOM 5218 N NE  . ARG B 1 103 ? 151.187 117.492 128.485 1.00 89.13  ? 103 ARG B NE  1 
ATOM 5219 C CZ  . ARG B 1 103 ? 150.586 117.970 129.567 1.00 87.49  ? 103 ARG B CZ  1 
ATOM 5220 N NH1 . ARG B 1 103 ? 149.288 117.810 129.765 1.00 86.10  ? 103 ARG B NH1 1 
ATOM 5221 N NH2 . ARG B 1 103 ? 151.307 118.625 130.473 1.00 84.27  ? 103 ARG B NH2 1 
ATOM 5222 N N   . THR B 1 104 ? 152.740 112.742 124.885 1.00 70.08  ? 104 THR B N   1 
ATOM 5223 C CA  . THR B 1 104 ? 152.810 111.288 124.900 1.00 71.56  ? 104 THR B CA  1 
ATOM 5224 C C   . THR B 1 104 ? 151.710 110.671 125.757 1.00 71.18  ? 104 THR B C   1 
ATOM 5225 O O   . THR B 1 104 ? 151.337 109.519 125.524 1.00 71.24  ? 104 THR B O   1 
ATOM 5226 C CB  . THR B 1 104 ? 154.198 110.857 125.392 1.00 74.72  ? 104 THR B CB  1 
ATOM 5227 O OG1 . THR B 1 104 ? 155.197 111.626 124.711 1.00 71.17  ? 104 THR B OG1 1 
ATOM 5228 C CG2 . THR B 1 104 ? 154.462 109.383 125.107 1.00 73.57  ? 104 THR B CG2 1 
ATOM 5229 N N   . SER B 1 105 ? 151.161 111.423 126.717 1.00 66.13  ? 105 SER B N   1 
ATOM 5230 C CA  . SER B 1 105 ? 150.131 110.880 127.600 1.00 69.67  ? 105 SER B CA  1 
ATOM 5231 C C   . SER B 1 105 ? 148.840 110.568 126.846 1.00 71.78  ? 105 SER B C   1 
ATOM 5232 O O   . SER B 1 105 ? 148.204 109.536 127.097 1.00 73.91  ? 105 SER B O   1 
ATOM 5233 C CB  . SER B 1 105 ? 149.861 111.857 128.743 1.00 66.11  ? 105 SER B CB  1 
ATOM 5234 O OG  . SER B 1 105 ? 149.625 113.162 128.246 1.00 66.10  ? 105 SER B OG  1 
ATOM 5235 N N   . HIS B 1 106 ? 148.449 111.438 125.911 1.00 67.54  ? 106 HIS B N   1 
ATOM 5236 C CA  . HIS B 1 106 ? 147.197 111.254 125.181 1.00 66.53  ? 106 HIS B CA  1 
ATOM 5237 C C   . HIS B 1 106 ? 147.252 110.024 124.278 1.00 70.22  ? 106 HIS B C   1 
ATOM 5238 O O   . HIS B 1 106 ? 146.357 109.166 124.319 1.00 71.55  ? 106 HIS B O   1 
ATOM 5239 C CB  . HIS B 1 106 ? 146.891 112.517 124.375 1.00 64.31  ? 106 HIS B CB  1 
ATOM 5240 C CG  . HIS B 1 106 ? 145.903 112.315 123.270 1.00 64.06  ? 106 HIS B CG  1 
ATOM 5241 N ND1 . HIS B 1 106 ? 144.541 112.357 123.473 1.00 67.96  ? 106 HIS B ND1 1 
ATOM 5242 C CD2 . HIS B 1 106 ? 146.079 112.097 121.945 1.00 64.25  ? 106 HIS B CD2 1 
ATOM 5243 C CE1 . HIS B 1 106 ? 143.920 112.160 122.324 1.00 66.45  ? 106 HIS B CE1 1 
ATOM 5244 N NE2 . HIS B 1 106 ? 144.830 111.999 121.381 1.00 66.69  ? 106 HIS B NE2 1 
ATOM 5245 N N   . ASN B 1 107 ? 148.307 109.914 123.464 1.00 63.82  ? 107 ASN B N   1 
ATOM 5246 C CA  . ASN B 1 107 ? 148.464 108.741 122.611 1.00 62.85  ? 107 ASN B CA  1 
ATOM 5247 C C   . ASN B 1 107 ? 148.755 107.489 123.426 1.00 59.52  ? 107 ASN B C   1 
ATOM 5248 O O   . ASN B 1 107 ? 148.379 106.388 123.013 1.00 59.17  ? 107 ASN B O   1 
ATOM 5249 C CB  . ASN B 1 107 ? 149.566 108.980 121.583 1.00 59.64  ? 107 ASN B CB  1 
ATOM 5250 C CG  . ASN B 1 107 ? 149.035 109.556 120.292 1.00 56.73  ? 107 ASN B CG  1 
ATOM 5251 O OD1 . ASN B 1 107 ? 148.093 110.346 120.293 1.00 51.64  ? 107 ASN B OD1 1 
ATOM 5252 N ND2 . ASN B 1 107 ? 149.636 109.164 119.181 1.00 60.97  ? 107 ASN B ND2 1 
ATOM 5253 N N   . LEU B 1 108 ? 149.401 107.643 124.585 1.00 55.61  ? 108 LEU B N   1 
ATOM 5254 C CA  . LEU B 1 108 ? 149.577 106.534 125.518 1.00 54.87  ? 108 LEU B CA  1 
ATOM 5255 C C   . LEU B 1 108 ? 148.236 105.976 125.967 1.00 61.95  ? 108 LEU B C   1 
ATOM 5256 O O   . LEU B 1 108 ? 148.019 104.758 125.942 1.00 67.27  ? 108 LEU B O   1 
ATOM 5257 C CB  . LEU B 1 108 ? 150.391 107.012 126.723 1.00 54.55  ? 108 LEU B CB  1 
ATOM 5258 C CG  . LEU B 1 108 ? 150.539 106.184 128.003 1.00 59.01  ? 108 LEU B CG  1 
ATOM 5259 C CD1 . LEU B 1 108 ? 151.933 106.373 128.540 1.00 60.20  ? 108 LEU B CD1 1 
ATOM 5260 C CD2 . LEU B 1 108 ? 149.532 106.593 129.071 1.00 62.56  ? 108 LEU B CD2 1 
ATOM 5261 N N   . ALA B 1 109 ? 147.322 106.859 126.373 1.00 49.65  ? 109 ALA B N   1 
ATOM 5262 C CA  . ALA B 1 109 ? 146.017 106.416 126.847 1.00 50.93  ? 109 ALA B CA  1 
ATOM 5263 C C   . ALA B 1 109 ? 145.185 105.813 125.717 1.00 53.83  ? 109 ALA B C   1 
ATOM 5264 O O   . ALA B 1 109 ? 144.518 104.785 125.911 1.00 54.31  ? 109 ALA B O   1 
ATOM 5265 C CB  . ALA B 1 109 ? 145.292 107.583 127.513 1.00 52.87  ? 109 ALA B CB  1 
ATOM 5266 N N   . GLU B 1 110 ? 145.234 106.418 124.523 1.00 49.48  ? 110 GLU B N   1 
ATOM 5267 C CA  . GLU B 1 110 ? 144.521 105.847 123.379 1.00 53.49  ? 110 GLU B CA  1 
ATOM 5268 C C   . GLU B 1 110 ? 145.059 104.469 123.006 1.00 52.33  ? 110 GLU B C   1 
ATOM 5269 O O   . GLU B 1 110 ? 144.285 103.533 122.753 1.00 49.72  ? 110 GLU B O   1 
ATOM 5270 C CB  . GLU B 1 110 ? 144.608 106.776 122.171 1.00 52.17  ? 110 GLU B CB  1 
ATOM 5271 C CG  . GLU B 1 110 ? 143.438 106.625 121.218 1.00 54.40  ? 110 GLU B CG  1 
ATOM 5272 C CD  . GLU B 1 110 ? 143.745 107.150 119.836 1.00 54.97  ? 110 GLU B CD  1 
ATOM 5273 O OE1 . GLU B 1 110 ? 142.809 107.263 119.019 1.00 53.49  ? 110 GLU B OE1 1 
ATOM 5274 O OE2 . GLU B 1 110 ? 144.927 107.442 119.563 1.00 54.60  ? 110 GLU B OE2 1 
ATOM 5275 N N   . LEU B 1 111 ? 146.383 104.316 122.983 1.00 41.70  ? 111 LEU B N   1 
ATOM 5276 C CA  . LEU B 1 111 ? 146.965 103.050 122.569 1.00 41.71  ? 111 LEU B CA  1 
ATOM 5277 C C   . LEU B 1 111 ? 146.787 101.972 123.631 1.00 46.23  ? 111 LEU B C   1 
ATOM 5278 O O   . LEU B 1 111 ? 146.639 100.796 123.287 1.00 43.34  ? 111 LEU B O   1 
ATOM 5279 C CB  . LEU B 1 111 ? 148.438 103.249 122.218 1.00 42.45  ? 111 LEU B CB  1 
ATOM 5280 C CG  . LEU B 1 111 ? 148.833 103.486 120.750 1.00 41.22  ? 111 LEU B CG  1 
ATOM 5281 C CD1 . LEU B 1 111 ? 148.881 102.179 119.981 1.00 40.06  ? 111 LEU B CD1 1 
ATOM 5282 C CD2 . LEU B 1 111 ? 147.910 104.472 120.044 1.00 43.51  ? 111 LEU B CD2 1 
ATOM 5283 N N   . GLU B 1 112 ? 146.755 102.339 124.918 1.00 37.33  ? 112 GLU B N   1 
ATOM 5284 C CA  . GLU B 1 112 ? 146.465 101.323 125.928 1.00 41.03  ? 112 GLU B CA  1 
ATOM 5285 C C   . GLU B 1 112 ? 144.994 100.918 125.908 1.00 40.22  ? 112 GLU B C   1 
ATOM 5286 O O   . GLU B 1 112 ? 144.675 99.746  126.156 1.00 39.40  ? 112 GLU B O   1 
ATOM 5287 C CB  . GLU B 1 112 ? 146.902 101.793 127.322 1.00 40.75  ? 112 GLU B CB  1 
ATOM 5288 C CG  . GLU B 1 112 ? 146.089 102.908 127.963 1.00 39.98  ? 112 GLU B CG  1 
ATOM 5289 C CD  . GLU B 1 112 ? 144.955 102.400 128.837 1.00 40.70  ? 112 GLU B CD  1 
ATOM 5290 O OE1 . GLU B 1 112 ? 145.019 101.236 129.282 1.00 47.94  ? 112 GLU B OE1 1 
ATOM 5291 O OE2 . GLU B 1 112 ? 143.998 103.167 129.077 1.00 42.13  ? 112 GLU B OE2 1 
ATOM 5292 N N   . ALA B 1 113 ? 144.088 101.852 125.580 1.00 46.21  ? 113 ALA B N   1 
ATOM 5293 C CA  . ALA B 1 113 ? 142.689 101.476 125.383 1.00 44.46  ? 113 ALA B CA  1 
ATOM 5294 C C   . ALA B 1 113 ? 142.535 100.519 124.206 1.00 36.84  ? 113 ALA B C   1 
ATOM 5295 O O   . ALA B 1 113 ? 141.776 99.544  124.281 1.00 45.21  ? 113 ALA B O   1 
ATOM 5296 C CB  . ALA B 1 113 ? 141.830 102.723 125.178 1.00 36.71  ? 113 ALA B CB  1 
ATOM 5297 N N   . TYR B 1 114 ? 143.268 100.764 123.119 1.00 28.60  ? 114 TYR B N   1 
ATOM 5298 C CA  . TYR B 1 114 ? 143.202 99.847  121.984 1.00 30.95  ? 114 TYR B CA  1 
ATOM 5299 C C   . TYR B 1 114 ? 143.866 98.506  122.282 1.00 29.04  ? 114 TYR B C   1 
ATOM 5300 O O   . TYR B 1 114 ? 143.438 97.476  121.747 1.00 34.86  ? 114 TYR B O   1 
ATOM 5301 C CB  . TYR B 1 114 ? 143.828 100.491 120.759 1.00 28.48  ? 114 TYR B CB  1 
ATOM 5302 C CG  . TYR B 1 114 ? 142.813 101.204 119.913 1.00 32.70  ? 114 TYR B CG  1 
ATOM 5303 C CD1 . TYR B 1 114 ? 142.191 102.357 120.366 1.00 32.41  ? 114 TYR B CD1 1 
ATOM 5304 C CD2 . TYR B 1 114 ? 142.461 100.714 118.667 1.00 38.78  ? 114 TYR B CD2 1 
ATOM 5305 C CE1 . TYR B 1 114 ? 141.257 103.010 119.591 1.00 36.21  ? 114 TYR B CE1 1 
ATOM 5306 C CE2 . TYR B 1 114 ? 141.529 101.355 117.890 1.00 37.52  ? 114 TYR B CE2 1 
ATOM 5307 C CZ  . TYR B 1 114 ? 140.930 102.502 118.352 1.00 29.82  ? 114 TYR B CZ  1 
ATOM 5308 O OH  . TYR B 1 114 ? 139.998 103.140 117.567 1.00 36.52  ? 114 TYR B OH  1 
ATOM 5309 N N   . LEU B 1 115 ? 144.904 98.495  123.121 1.00 29.40  ? 115 LEU B N   1 
ATOM 5310 C CA  . LEU B 1 115 ? 145.484 97.234  123.575 1.00 37.07  ? 115 LEU B CA  1 
ATOM 5311 C C   . LEU B 1 115 ? 144.467 96.422  124.370 1.00 37.50  ? 115 LEU B C   1 
ATOM 5312 O O   . LEU B 1 115 ? 144.346 95.201  124.191 1.00 33.57  ? 115 LEU B O   1 
ATOM 5313 C CB  . LEU B 1 115 ? 146.730 97.512  124.416 1.00 28.30  ? 115 LEU B CB  1 
ATOM 5314 C CG  . LEU B 1 115 ? 147.432 96.317  125.062 1.00 25.55  ? 115 LEU B CG  1 
ATOM 5315 C CD1 . LEU B 1 115 ? 148.468 95.745  124.119 1.00 35.11  ? 115 LEU B CD1 1 
ATOM 5316 C CD2 . LEU B 1 115 ? 148.066 96.713  126.383 1.00 31.92  ? 115 LEU B CD2 1 
ATOM 5317 N N   . ALA B 1 116 ? 143.713 97.097  125.244 1.00 29.77  ? 116 ALA B N   1 
ATOM 5318 C CA  . ALA B 1 116 ? 142.644 96.427  125.978 1.00 33.16  ? 116 ALA B CA  1 
ATOM 5319 C C   . ALA B 1 116 ? 141.568 95.900  125.032 1.00 38.82  ? 116 ALA B C   1 
ATOM 5320 O O   . ALA B 1 116 ? 141.038 94.796  125.233 1.00 33.25  ? 116 ALA B O   1 
ATOM 5321 C CB  . ALA B 1 116 ? 142.038 97.380  127.007 1.00 33.39  ? 116 ALA B CB  1 
ATOM 5322 N N   . ALA B 1 117 ? 141.242 96.675  123.992 1.00 39.66  ? 117 ALA B N   1 
ATOM 5323 C CA  . ALA B 1 117 ? 140.253 96.236  123.010 1.00 25.30  ? 117 ALA B CA  1 
ATOM 5324 C C   . ALA B 1 117 ? 140.707 94.981  122.282 1.00 21.92  ? 117 ALA B C   1 
ATOM 5325 O O   . ALA B 1 117 ? 139.919 94.045  122.097 1.00 33.64  ? 117 ALA B O   1 
ATOM 5326 C CB  . ALA B 1 117 ? 139.963 97.355  122.011 1.00 24.58  ? 117 ALA B CB  1 
ATOM 5327 N N   . LEU B 1 118 ? 141.977 94.933  121.881 1.00 12.74  ? 118 LEU B N   1 
ATOM 5328 C CA  . LEU B 1 118 ? 142.468 93.755  121.176 1.00 21.35  ? 118 LEU B CA  1 
ATOM 5329 C C   . LEU B 1 118 ? 142.527 92.538  122.092 1.00 23.89  ? 118 LEU B C   1 
ATOM 5330 O O   . LEU B 1 118 ? 142.223 91.424  121.654 1.00 34.68  ? 118 LEU B O   1 
ATOM 5331 C CB  . LEU B 1 118 ? 143.833 94.030  120.553 1.00 49.19  ? 118 LEU B CB  1 
ATOM 5332 C CG  . LEU B 1 118 ? 143.975 93.533  119.111 1.00 43.56  ? 118 LEU B CG  1 
ATOM 5333 C CD1 . LEU B 1 118 ? 142.798 93.981  118.258 1.00 27.67  ? 118 LEU B CD1 1 
ATOM 5334 C CD2 . LEU B 1 118 ? 145.285 94.001  118.505 1.00 36.52  ? 118 LEU B CD2 1 
ATOM 5335 N N   . THR B 1 119 ? 142.889 92.725  123.367 1.00 34.62  ? 119 THR B N   1 
ATOM 5336 C CA  . THR B 1 119 ? 142.897 91.586  124.289 1.00 44.26  ? 119 THR B CA  1 
ATOM 5337 C C   . THR B 1 119 ? 141.490 91.036  124.518 1.00 36.89  ? 119 THR B C   1 
ATOM 5338 O O   . THR B 1 119 ? 141.281 89.811  124.510 1.00 40.81  ? 119 THR B O   1 
ATOM 5339 C CB  . THR B 1 119 ? 143.531 91.974  125.626 1.00 37.86  ? 119 THR B CB  1 
ATOM 5340 O OG1 . THR B 1 119 ? 142.918 93.168  126.121 1.00 37.14  ? 119 THR B OG1 1 
ATOM 5341 C CG2 . THR B 1 119 ? 145.026 92.196  125.470 1.00 22.28  ? 119 THR B CG2 1 
ATOM 5342 N N   . GLN B 1 120 ? 140.506 91.922  124.708 1.00 39.70  ? 120 GLN B N   1 
ATOM 5343 C CA  . GLN B 1 120 ? 139.144 91.454  124.957 1.00 36.22  ? 120 GLN B CA  1 
ATOM 5344 C C   . GLN B 1 120 ? 138.537 90.808  123.716 1.00 30.49  ? 120 GLN B C   1 
ATOM 5345 O O   . GLN B 1 120 ? 137.821 89.803  123.820 1.00 35.56  ? 120 GLN B O   1 
ATOM 5346 C CB  . GLN B 1 120 ? 138.277 92.606  125.456 1.00 45.28  ? 120 GLN B CB  1 
ATOM 5347 C CG  . GLN B 1 120 ? 138.667 93.089  126.838 1.00 47.67  ? 120 GLN B CG  1 
ATOM 5348 C CD  . GLN B 1 120 ? 139.074 91.953  127.751 1.00 45.79  ? 120 GLN B CD  1 
ATOM 5349 O OE1 . GLN B 1 120 ? 140.251 91.791  128.074 1.00 33.44  ? 120 GLN B OE1 1 
ATOM 5350 N NE2 . GLN B 1 120 ? 138.099 91.162  128.179 1.00 47.93  ? 120 GLN B NE2 1 
ATOM 5351 N N   . LEU B 1 121 ? 138.827 91.351  122.531 1.00 35.26  ? 121 LEU B N   1 
ATOM 5352 C CA  . LEU B 1 121 ? 138.369 90.695  121.315 1.00 23.16  ? 121 LEU B CA  1 
ATOM 5353 C C   . LEU B 1 121 ? 139.074 89.364  121.097 1.00 29.23  ? 121 LEU B C   1 
ATOM 5354 O O   . LEU B 1 121 ? 138.475 88.442  120.536 1.00 36.62  ? 121 LEU B O   1 
ATOM 5355 C CB  . LEU B 1 121 ? 138.568 91.609  120.110 1.00 22.99  ? 121 LEU B CB  1 
ATOM 5356 C CG  . LEU B 1 121 ? 137.488 92.670  119.907 1.00 19.07  ? 121 LEU B CG  1 
ATOM 5357 C CD1 . LEU B 1 121 ? 137.592 93.271  118.524 1.00 27.59  ? 121 LEU B CD1 1 
ATOM 5358 C CD2 . LEU B 1 121 ? 136.110 92.093  120.127 1.00 39.48  ? 121 LEU B CD2 1 
ATOM 5359 N N   . ARG B 1 122 ? 140.329 89.235  121.543 1.00 38.89  ? 122 ARG B N   1 
ATOM 5360 C CA  . ARG B 1 122 ? 141.004 87.940  121.494 1.00 47.59  ? 122 ARG B CA  1 
ATOM 5361 C C   . ARG B 1 122 ? 140.293 86.918  122.372 1.00 47.88  ? 122 ARG B C   1 
ATOM 5362 O O   . ARG B 1 122 ? 140.087 85.767  121.959 1.00 43.95  ? 122 ARG B O   1 
ATOM 5363 C CB  . ARG B 1 122 ? 142.464 88.100  121.920 1.00 41.93  ? 122 ARG B CB  1 
ATOM 5364 C CG  . ARG B 1 122 ? 143.101 86.843  122.486 1.00 39.32  ? 122 ARG B CG  1 
ATOM 5365 C CD  . ARG B 1 122 ? 144.604 86.849  122.303 1.00 40.94  ? 122 ARG B CD  1 
ATOM 5366 N NE  . ARG B 1 122 ? 145.266 85.932  123.222 1.00 48.19  ? 122 ARG B NE  1 
ATOM 5367 C CZ  . ARG B 1 122 ? 146.580 85.828  123.357 1.00 46.12  ? 122 ARG B CZ  1 
ATOM 5368 N NH1 . ARG B 1 122 ? 147.409 86.580  122.653 1.00 37.24  ? 122 ARG B NH1 1 
ATOM 5369 N NH2 . ARG B 1 122 ? 147.076 84.947  124.222 1.00 47.99  ? 122 ARG B NH2 1 
ATOM 5370 N N   . ALA B 1 123 ? 139.891 87.332  123.578 1.00 42.19  ? 123 ALA B N   1 
ATOM 5371 C CA  . ALA B 1 123 ? 139.145 86.435  124.460 1.00 47.98  ? 123 ALA B CA  1 
ATOM 5372 C C   . ALA B 1 123 ? 137.802 86.034  123.851 1.00 50.95  ? 123 ALA B C   1 
ATOM 5373 O O   . ALA B 1 123 ? 137.400 84.865  123.926 1.00 51.29  ? 123 ALA B O   1 
ATOM 5374 C CB  . ALA B 1 123 ? 138.942 87.089  125.825 1.00 47.04  ? 123 ALA B CB  1 
ATOM 5375 N N   . LEU B 1 124 ? 137.104 86.988  123.222 1.00 47.66  ? 124 LEU B N   1 
ATOM 5376 C CA  . LEU B 1 124 ? 135.819 86.673  122.594 1.00 36.27  ? 124 LEU B CA  1 
ATOM 5377 C C   . LEU B 1 124 ? 135.983 85.737  121.398 1.00 39.88  ? 124 LEU B C   1 
ATOM 5378 O O   . LEU B 1 124 ? 135.153 84.845  121.187 1.00 52.74  ? 124 LEU B O   1 
ATOM 5379 C CB  . LEU B 1 124 ? 135.102 87.953  122.164 1.00 37.13  ? 124 LEU B CB  1 
ATOM 5380 C CG  . LEU B 1 124 ? 134.624 88.947  123.224 1.00 35.51  ? 124 LEU B CG  1 
ATOM 5381 C CD1 . LEU B 1 124 ? 133.455 89.753  122.686 1.00 32.41  ? 124 LEU B CD1 1 
ATOM 5382 C CD2 . LEU B 1 124 ? 134.250 88.257  124.522 1.00 34.35  ? 124 LEU B CD2 1 
ATOM 5383 N N   . VAL B 1 125 ? 137.035 85.928  120.599 1.00 37.41  ? 125 VAL B N   1 
ATOM 5384 C CA  . VAL B 1 125 ? 137.257 85.064  119.442 1.00 41.56  ? 125 VAL B CA  1 
ATOM 5385 C C   . VAL B 1 125 ? 137.628 83.652  119.890 1.00 41.54  ? 125 VAL B C   1 
ATOM 5386 O O   . VAL B 1 125 ? 137.194 82.658  119.289 1.00 45.22  ? 125 VAL B O   1 
ATOM 5387 C CB  . VAL B 1 125 ? 138.318 85.691  118.518 1.00 40.98  ? 125 VAL B CB  1 
ATOM 5388 C CG1 . VAL B 1 125 ? 138.811 84.701  117.492 1.00 44.69  ? 125 VAL B CG1 1 
ATOM 5389 C CG2 . VAL B 1 125 ? 137.737 86.896  117.806 1.00 46.18  ? 125 VAL B CG2 1 
ATOM 5390 N N   . TYR B 1 126 ? 138.402 83.538  120.974 1.00 38.79  ? 126 TYR B N   1 
ATOM 5391 C CA  . TYR B 1 126 ? 138.677 82.223  121.549 1.00 39.04  ? 126 TYR B CA  1 
ATOM 5392 C C   . TYR B 1 126 ? 137.399 81.561  122.062 1.00 50.75  ? 126 TYR B C   1 
ATOM 5393 O O   . TYR B 1 126 ? 137.220 80.344  121.914 1.00 58.10  ? 126 TYR B O   1 
ATOM 5394 C CB  . TYR B 1 126 ? 139.703 82.343  122.675 1.00 45.00  ? 126 TYR B CB  1 
ATOM 5395 C CG  . TYR B 1 126 ? 141.142 82.366  122.210 1.00 56.80  ? 126 TYR B CG  1 
ATOM 5396 C CD1 . TYR B 1 126 ? 141.462 82.266  120.861 1.00 62.16  ? 126 TYR B CD1 1 
ATOM 5397 C CD2 . TYR B 1 126 ? 142.181 82.487  123.123 1.00 53.96  ? 126 TYR B CD2 1 
ATOM 5398 C CE1 . TYR B 1 126 ? 142.776 82.287  120.436 1.00 54.33  ? 126 TYR B CE1 1 
ATOM 5399 C CE2 . TYR B 1 126 ? 143.498 82.508  122.708 1.00 50.59  ? 126 TYR B CE2 1 
ATOM 5400 C CZ  . TYR B 1 126 ? 143.789 82.408  121.364 1.00 49.87  ? 126 TYR B CZ  1 
ATOM 5401 O OH  . TYR B 1 126 ? 145.100 82.428  120.948 1.00 48.90  ? 126 TYR B OH  1 
ATOM 5402 N N   . TYR B 1 127 ? 136.500 82.349  122.665 1.00 54.49  ? 127 TYR B N   1 
ATOM 5403 C CA  . TYR B 1 127 ? 135.212 81.815  123.110 1.00 54.91  ? 127 TYR B CA  1 
ATOM 5404 C C   . TYR B 1 127 ? 134.369 81.318  121.937 1.00 46.46  ? 127 TYR B C   1 
ATOM 5405 O O   . TYR B 1 127 ? 133.714 80.273  122.035 1.00 41.35  ? 127 TYR B O   1 
ATOM 5406 C CB  . TYR B 1 127 ? 134.450 82.878  123.897 1.00 60.45  ? 127 TYR B CB  1 
ATOM 5407 C CG  . TYR B 1 127 ? 134.528 82.710  125.395 1.00 57.96  ? 127 TYR B CG  1 
ATOM 5408 C CD1 . TYR B 1 127 ? 135.746 82.521  126.028 1.00 51.27  ? 127 TYR B CD1 1 
ATOM 5409 C CD2 . TYR B 1 127 ? 133.380 82.744  126.175 1.00 59.15  ? 127 TYR B CD2 1 
ATOM 5410 C CE1 . TYR B 1 127 ? 135.818 82.369  127.396 1.00 54.75  ? 127 TYR B CE1 1 
ATOM 5411 C CE2 . TYR B 1 127 ? 133.442 82.593  127.543 1.00 54.49  ? 127 TYR B CE2 1 
ATOM 5412 C CZ  . TYR B 1 127 ? 134.663 82.406  128.148 1.00 60.38  ? 127 TYR B CZ  1 
ATOM 5413 O OH  . TYR B 1 127 ? 134.731 82.257  129.512 1.00 69.24  ? 127 TYR B OH  1 
ATOM 5414 N N   . ALA B 1 128 ? 134.366 82.061  120.826 1.00 40.57  ? 128 ALA B N   1 
ATOM 5415 C CA  . ALA B 1 128 ? 133.640 81.629  119.632 1.00 26.46  ? 128 ALA B CA  1 
ATOM 5416 C C   . ALA B 1 128 ? 134.213 80.336  119.067 1.00 40.83  ? 128 ALA B C   1 
ATOM 5417 O O   . ALA B 1 128 ? 133.463 79.440  118.650 1.00 50.35  ? 128 ALA B O   1 
ATOM 5418 C CB  . ALA B 1 128 ? 133.672 82.725  118.570 1.00 39.98  ? 128 ALA B CB  1 
ATOM 5419 N N   . GLN B 1 129 ? 135.544 80.223  119.042 1.00 62.16  ? 129 GLN B N   1 
ATOM 5420 C CA  . GLN B 1 129 ? 136.179 78.994  118.574 1.00 63.98  ? 129 GLN B CA  1 
ATOM 5421 C C   . GLN B 1 129 ? 135.823 77.809  119.466 1.00 57.29  ? 129 GLN B C   1 
ATOM 5422 O O   . GLN B 1 129 ? 135.526 76.713  118.967 1.00 60.65  ? 129 GLN B O   1 
ATOM 5423 C CB  . GLN B 1 129 ? 137.692 79.183  118.509 1.00 62.36  ? 129 GLN B CB  1 
ATOM 5424 C CG  . GLN B 1 129 ? 138.437 77.981  117.970 1.00 63.70  ? 129 GLN B CG  1 
ATOM 5425 C CD  . GLN B 1 129 ? 139.768 78.356  117.366 1.00 60.72  ? 129 GLN B CD  1 
ATOM 5426 O OE1 . GLN B 1 129 ? 140.797 77.760  117.680 1.00 65.85  ? 129 GLN B OE1 1 
ATOM 5427 N NE2 . GLN B 1 129 ? 139.756 79.352  116.489 1.00 59.96  ? 129 GLN B NE2 1 
ATOM 5428 N N   . ARG B 1 130 ? 135.822 78.020  120.787 1.00 61.40  ? 130 ARG B N   1 
ATOM 5429 C CA  . ARG B 1 130 ? 135.478 76.945  121.712 1.00 62.34  ? 130 ARG B CA  1 
ATOM 5430 C C   . ARG B 1 130 ? 134.015 76.538  121.574 1.00 66.29  ? 130 ARG B C   1 
ATOM 5431 O O   . ARG B 1 130 ? 133.693 75.345  121.659 1.00 67.60  ? 130 ARG B O   1 
ATOM 5432 C CB  . ARG B 1 130 ? 135.801 77.375  123.144 1.00 65.89  ? 130 ARG B CB  1 
ATOM 5433 C CG  . ARG B 1 130 ? 135.361 76.406  124.231 1.00 69.59  ? 130 ARG B CG  1 
ATOM 5434 C CD  . ARG B 1 130 ? 134.545 77.064  125.356 1.00 65.37  ? 130 ARG B CD  1 
ATOM 5435 N NE  . ARG B 1 130 ? 133.288 77.709  124.983 1.00 71.65  ? 130 ARG B NE  1 
ATOM 5436 C CZ  . ARG B 1 130 ? 132.242 77.113  124.422 1.00 71.26  ? 130 ARG B CZ  1 
ATOM 5437 N NH1 . ARG B 1 130 ? 132.250 75.828  124.113 1.00 66.99  ? 130 ARG B NH1 1 
ATOM 5438 N NH2 . ARG B 1 130 ? 131.144 77.821  124.186 1.00 68.20  ? 130 ARG B NH2 1 
ATOM 5439 N N   . LEU B 1 131 ? 133.141 77.508  121.332 1.00 71.24  ? 131 LEU B N   1 
ATOM 5440 C CA  . LEU B 1 131 ? 131.735 77.195  121.126 1.00 70.23  ? 131 LEU B CA  1 
ATOM 5441 C C   . LEU B 1 131 ? 131.573 76.357  119.878 1.00 64.05  ? 131 LEU B C   1 
ATOM 5442 O O   . LEU B 1 131 ? 131.040 75.248  119.929 1.00 66.39  ? 131 LEU B O   1 
ATOM 5443 C CB  . LEU B 1 131 ? 130.915 78.476  121.003 1.00 68.99  ? 131 LEU B CB  1 
ATOM 5444 C CG  . LEU B 1 131 ? 129.417 78.281  120.767 1.00 58.96  ? 131 LEU B CG  1 
ATOM 5445 C CD1 . LEU B 1 131 ? 128.845 77.253  121.732 1.00 65.69  ? 131 LEU B CD1 1 
ATOM 5446 C CD2 . LEU B 1 131 ? 128.676 79.605  120.882 1.00 67.14  ? 131 LEU B CD2 1 
ATOM 5447 N N   . LEU B 1 132 ? 132.031 76.888  118.751 1.00 59.30  ? 132 LEU B N   1 
ATOM 5448 C CA  . LEU B 1 132 ? 131.929 76.162  117.496 1.00 57.60  ? 132 LEU B CA  1 
ATOM 5449 C C   . LEU B 1 132 ? 132.419 74.734  117.665 1.00 72.14  ? 132 LEU B C   1 
ATOM 5450 O O   . LEU B 1 132 ? 131.758 73.786  117.249 1.00 67.93  ? 132 LEU B O   1 
ATOM 5451 C CB  . LEU B 1 132 ? 132.737 76.869  116.411 1.00 58.26  ? 132 LEU B CB  1 
ATOM 5452 C CG  . LEU B 1 132 ? 132.433 76.459  114.971 1.00 64.30  ? 132 LEU B CG  1 
ATOM 5453 C CD1 . LEU B 1 132 ? 133.407 75.390  114.501 1.00 64.23  ? 132 LEU B CD1 1 
ATOM 5454 C CD2 . LEU B 1 132 ? 130.995 75.983  114.827 1.00 72.35  ? 132 LEU B CD2 1 
ATOM 5455 N N   . VAL B 1 133 ? 133.587 74.578  118.270 1.00 84.74  ? 133 VAL B N   1 
ATOM 5456 C CA  . VAL B 1 133 ? 134.127 73.248  118.487 1.00 74.44  ? 133 VAL B CA  1 
ATOM 5457 C C   . VAL B 1 133 ? 133.137 72.397  119.262 1.00 72.67  ? 133 VAL B C   1 
ATOM 5458 O O   . VAL B 1 133 ? 132.676 71.369  118.769 1.00 71.81  ? 133 VAL B O   1 
ATOM 5459 C CB  . VAL B 1 133 ? 135.456 73.310  119.258 1.00 74.40  ? 133 VAL B CB  1 
ATOM 5460 C CG1 . VAL B 1 133 ? 135.826 71.937  119.798 1.00 74.67  ? 133 VAL B CG1 1 
ATOM 5461 C CG2 . VAL B 1 133 ? 136.559 73.847  118.361 1.00 74.33  ? 133 VAL B CG2 1 
ATOM 5462 N N   . THR B 1 134 ? 132.797 72.828  120.468 1.00 85.28  ? 134 THR B N   1 
ATOM 5463 C CA  . THR B 1 134 ? 131.894 72.057  121.318 1.00 88.01  ? 134 THR B CA  1 
ATOM 5464 C C   . THR B 1 134 ? 130.611 71.597  120.644 1.00 85.86  ? 134 THR B C   1 
ATOM 5465 O O   . THR B 1 134 ? 130.224 70.438  120.778 1.00 82.59  ? 134 THR B O   1 
ATOM 5466 C CB  . THR B 1 134 ? 131.498 72.895  122.549 1.00 84.84  ? 134 THR B CB  1 
ATOM 5467 O OG1 . THR B 1 134 ? 132.680 73.296  123.253 1.00 81.71  ? 134 THR B OG1 1 
ATOM 5468 C CG2 . THR B 1 134 ? 130.601 72.096  123.480 1.00 81.98  ? 134 THR B CG2 1 
ATOM 5469 N N   . ASN B 1 135 ? 129.952 72.482  119.911 1.00 86.83  ? 135 ASN B N   1 
ATOM 5470 C CA  . ASN B 1 135 ? 128.659 72.151  119.326 1.00 88.36  ? 135 ASN B CA  1 
ATOM 5471 C C   . ASN B 1 135 ? 128.823 71.418  117.995 1.00 87.09  ? 135 ASN B C   1 
ATOM 5472 O O   . ASN B 1 135 ? 129.911 71.337  117.421 1.00 86.09  ? 135 ASN B O   1 
ATOM 5473 C CB  . ASN B 1 135 ? 127.800 73.406  119.138 1.00 87.23  ? 135 ASN B CB  1 
ATOM 5474 C CG  . ASN B 1 135 ? 128.052 74.108  117.814 1.00 88.58  ? 135 ASN B CG  1 
ATOM 5475 O OD1 . ASN B 1 135 ? 129.191 74.375  117.442 1.00 85.92  ? 135 ASN B OD1 1 
ATOM 5476 N ND2 . ASN B 1 135 ? 126.978 74.407  117.093 1.00 83.62  ? 135 ASN B ND2 1 
ATOM 5477 N N   . ARG B 1 136 ? 127.711 70.879  117.509 1.00 101.43 ? 136 ARG B N   1 
ATOM 5478 C CA  . ARG B 1 136 ? 127.675 70.208  116.215 1.00 99.87  ? 136 ARG B CA  1 
ATOM 5479 C C   . ARG B 1 136 ? 127.743 71.242  115.095 1.00 101.28 ? 136 ARG B C   1 
ATOM 5480 O O   . ARG B 1 136 ? 127.012 72.236  115.134 1.00 96.91  ? 136 ARG B O   1 
ATOM 5481 C CB  . ARG B 1 136 ? 126.403 69.368  116.094 1.00 96.06  ? 136 ARG B CB  1 
ATOM 5482 C CG  . ARG B 1 136 ? 125.919 69.109  114.674 1.00 97.59  ? 136 ARG B CG  1 
ATOM 5483 C CD  . ARG B 1 136 ? 126.739 68.027  113.989 1.00 95.90  ? 136 ARG B CD  1 
ATOM 5484 N NE  . ARG B 1 136 ? 126.892 66.844  114.827 1.00 97.99  ? 136 ARG B NE  1 
ATOM 5485 C CZ  . ARG B 1 136 ? 126.010 65.857  114.900 1.00 100.17 ? 136 ARG B CZ  1 
ATOM 5486 N NH1 . ARG B 1 136 ? 124.892 65.875  114.191 1.00 97.67  ? 136 ARG B NH1 1 
ATOM 5487 N NH2 . ARG B 1 136 ? 126.254 64.826  115.704 1.00 98.52  ? 136 ARG B NH2 1 
ATOM 5488 N N   . PRO B 1 137 ? 128.627 71.069  114.114 1.00 101.58 ? 137 PRO B N   1 
ATOM 5489 C CA  . PRO B 1 137 ? 128.633 71.978  112.963 1.00 97.99  ? 137 PRO B CA  1 
ATOM 5490 C C   . PRO B 1 137 ? 127.377 71.823  112.119 1.00 97.20  ? 137 PRO B C   1 
ATOM 5491 O O   . PRO B 1 137 ? 126.800 70.740  112.007 1.00 96.63  ? 137 PRO B O   1 
ATOM 5492 C CB  . PRO B 1 137 ? 129.883 71.561  112.179 1.00 96.25  ? 137 PRO B CB  1 
ATOM 5493 C CG  . PRO B 1 137 ? 130.720 70.793  113.149 1.00 98.26  ? 137 PRO B CG  1 
ATOM 5494 C CD  . PRO B 1 137 ? 129.759 70.128  114.082 1.00 97.91  ? 137 PRO B CD  1 
ATOM 5495 N N   . GLY B 1 138 ? 126.967 72.931  111.509 1.00 91.60  ? 138 GLY B N   1 
ATOM 5496 C CA  . GLY B 1 138 ? 125.787 72.987  110.682 1.00 90.44  ? 138 GLY B CA  1 
ATOM 5497 C C   . GLY B 1 138 ? 124.583 73.631  111.338 1.00 91.52  ? 138 GLY B C   1 
ATOM 5498 O O   . GLY B 1 138 ? 123.692 74.110  110.627 1.00 90.20  ? 138 GLY B O   1 
ATOM 5499 N N   . VAL B 1 139 ? 124.532 73.664  112.668 1.00 95.01  ? 139 VAL B N   1 
ATOM 5500 C CA  . VAL B 1 139 ? 123.433 74.284  113.396 1.00 93.86  ? 139 VAL B CA  1 
ATOM 5501 C C   . VAL B 1 139 ? 123.963 75.514  114.125 1.00 91.24  ? 139 VAL B C   1 
ATOM 5502 O O   . VAL B 1 139 ? 124.885 75.419  114.944 1.00 90.73  ? 139 VAL B O   1 
ATOM 5503 C CB  . VAL B 1 139 ? 122.742 73.291  114.355 1.00 94.20  ? 139 VAL B CB  1 
ATOM 5504 C CG1 . VAL B 1 139 ? 123.730 72.644  115.318 1.00 92.12  ? 139 VAL B CG1 1 
ATOM 5505 C CG2 . VAL B 1 139 ? 121.621 73.977  115.120 1.00 91.17  ? 139 VAL B CG2 1 
ATOM 5506 N N   . LEU B 1 140 ? 123.379 76.667  113.814 1.00 79.74  ? 140 LEU B N   1 
ATOM 5507 C CA  . LEU B 1 140 ? 123.749 77.958  114.379 1.00 77.03  ? 140 LEU B CA  1 
ATOM 5508 C C   . LEU B 1 140 ? 123.493 78.068  115.872 1.00 78.20  ? 140 LEU B C   1 
ATOM 5509 O O   . LEU B 1 140 ? 124.091 78.931  116.520 1.00 68.88  ? 140 LEU B O   1 
ATOM 5510 C CB  . LEU B 1 140 ? 122.971 79.047  113.652 1.00 73.53  ? 140 LEU B CB  1 
ATOM 5511 C CG  . LEU B 1 140 ? 123.464 80.371  113.086 1.00 71.32  ? 140 LEU B CG  1 
ATOM 5512 C CD1 . LEU B 1 140 ? 124.721 80.379  112.264 0.18 74.44  ? 140 LEU B CD1 1 
ATOM 5513 C CD2 . LEU B 1 140 ? 122.312 80.739  112.195 1.00 78.68  ? 140 LEU B CD2 1 
ATOM 5514 N N   . PHE B 1 141 ? 122.629 77.230  116.429 1.00 94.18  ? 141 PHE B N   1 
ATOM 5515 C CA  . PHE B 1 141 ? 122.221 77.324  117.819 1.00 90.16  ? 141 PHE B CA  1 
ATOM 5516 C C   . PHE B 1 141 ? 122.744 76.104  118.565 1.00 91.11  ? 141 PHE B C   1 
ATOM 5517 O O   . PHE B 1 141 ? 123.361 75.209  117.981 1.00 91.41  ? 141 PHE B O   1 
ATOM 5518 C CB  . PHE B 1 141 ? 120.695 77.440  117.921 1.00 89.92  ? 141 PHE B CB  1 
ATOM 5519 C CG  . PHE B 1 141 ? 120.222 78.317  119.039 1.00 87.65  ? 141 PHE B CG  1 
ATOM 5520 C CD1 . PHE B 1 141 ? 120.201 79.696  118.895 1.00 84.21  ? 141 PHE B CD1 1 
ATOM 5521 C CD2 . PHE B 1 141 ? 119.765 77.763  120.220 1.00 91.26  ? 141 PHE B CD2 1 
ATOM 5522 C CE1 . PHE B 1 141 ? 119.752 80.505  119.920 1.00 86.13  ? 141 PHE B CE1 1 
ATOM 5523 C CE2 . PHE B 1 141 ? 119.315 78.563  121.242 1.00 93.17  ? 141 PHE B CE2 1 
ATOM 5524 C CZ  . PHE B 1 141 ? 119.312 79.938  121.096 1.00 89.65  ? 141 PHE B CZ  1 
ATOM 5525 N N   . PHE B 1 142 ? 122.497 76.068  119.869 1.00 100.01 ? 142 PHE B N   1 
ATOM 5526 C CA  . PHE B 1 142 ? 122.939 74.974  120.719 1.00 100.41 ? 142 PHE B CA  1 
ATOM 5527 C C   . PHE B 1 142 ? 121.746 74.116  121.116 1.00 100.24 ? 142 PHE B C   1 
ATOM 5528 O O   . PHE B 1 142 ? 120.663 74.640  121.398 1.00 100.48 ? 142 PHE B O   1 
ATOM 5529 C CB  . PHE B 1 142 ? 123.654 75.498  121.963 1.00 102.50 ? 142 PHE B CB  1 
ATOM 5530 C CG  . PHE B 1 142 ? 124.572 74.497  122.588 1.00 100.63 ? 142 PHE B CG  1 
ATOM 5531 C CD1 . PHE B 1 142 ? 125.513 73.833  121.822 1.00 99.32  ? 142 PHE B CD1 1 
ATOM 5532 C CD2 . PHE B 1 142 ? 124.485 74.206  123.936 1.00 100.59 ? 142 PHE B CD2 1 
ATOM 5533 C CE1 . PHE B 1 142 ? 126.359 72.902  122.390 1.00 102.73 ? 142 PHE B CE1 1 
ATOM 5534 C CE2 . PHE B 1 142 ? 125.325 73.278  124.508 1.00 100.59 ? 142 PHE B CE2 1 
ATOM 5535 C CZ  . PHE B 1 142 ? 126.265 72.625  123.735 1.00 102.89 ? 142 PHE B CZ  1 
ATOM 5536 N N   . GLU B 1 143 ? 121.951 72.802  121.133 1.00 103.30 ? 143 GLU B N   1 
ATOM 5537 C CA  . GLU B 1 143 ? 120.910 71.838  121.461 1.00 105.42 ? 143 GLU B CA  1 
ATOM 5538 C C   . GLU B 1 143 ? 120.956 71.377  122.913 1.00 107.88 ? 143 GLU B C   1 
ATOM 5539 O O   . GLU B 1 143 ? 120.159 70.514  123.298 1.00 109.43 ? 143 GLU B O   1 
ATOM 5540 C CB  . GLU B 1 143 ? 121.016 70.623  120.530 1.00 106.46 ? 143 GLU B CB  1 
ATOM 5541 C CG  . GLU B 1 143 ? 122.160 69.668  120.863 1.00 107.59 ? 143 GLU B CG  1 
ATOM 5542 C CD  . GLU B 1 143 ? 123.504 70.143  120.342 1.00 107.17 ? 143 GLU B CD  1 
ATOM 5543 O OE1 . GLU B 1 143 ? 123.534 71.112  119.554 1.00 107.24 ? 143 GLU B OE1 1 
ATOM 5544 O OE2 . GLU B 1 143 ? 124.534 69.547  120.722 1.00 106.36 ? 143 GLU B OE2 1 
ATOM 5545 N N   . GLY B 1 144 ? 121.851 71.932  123.724 1.00 104.34 ? 144 GLY B N   1 
ATOM 5546 C CA  . GLY B 1 144 ? 122.031 71.457  125.080 1.00 104.99 ? 144 GLY B CA  1 
ATOM 5547 C C   . GLY B 1 144 ? 120.903 71.862  126.010 1.00 102.01 ? 144 GLY B C   1 
ATOM 5548 O O   . GLY B 1 144 ? 119.991 72.613  125.662 1.00 98.04  ? 144 GLY B O   1 
ATOM 5549 N N   . ASP B 1 145 ? 120.980 71.344  127.233 1.00 97.37  ? 145 ASP B N   1 
ATOM 5550 C CA  . ASP B 1 145 ? 119.955 71.577  128.241 1.00 96.98  ? 145 ASP B CA  1 
ATOM 5551 C C   . ASP B 1 145 ? 120.185 72.931  128.911 1.00 95.02  ? 145 ASP B C   1 
ATOM 5552 O O   . ASP B 1 145 ? 121.043 73.719  128.506 1.00 96.97  ? 145 ASP B O   1 
ATOM 5553 C CB  . ASP B 1 145 ? 119.939 70.432  129.250 1.00 95.34  ? 145 ASP B CB  1 
ATOM 5554 C CG  . ASP B 1 145 ? 118.536 70.072  129.700 1.00 96.84  ? 145 ASP B CG  1 
ATOM 5555 O OD1 . ASP B 1 145 ? 117.696 70.988  129.821 0.24 95.23  ? 145 ASP B OD1 1 
ATOM 5556 O OD2 . ASP B 1 145 ? 118.273 68.873  129.928 1.00 97.63  ? 145 ASP B OD2 1 
ATOM 5557 N N   . GLU B 1 146 ? 119.409 73.214  129.961 1.00 91.25  ? 146 GLU B N   1 
ATOM 5558 C CA  . GLU B 1 146 ? 119.464 74.528  130.595 1.00 90.00  ? 146 GLU B CA  1 
ATOM 5559 C C   . GLU B 1 146 ? 120.692 74.694  131.483 1.00 90.83  ? 146 GLU B C   1 
ATOM 5560 O O   . GLU B 1 146 ? 121.241 75.798  131.568 1.00 89.18  ? 146 GLU B O   1 
ATOM 5561 C CB  . GLU B 1 146 ? 118.192 74.768  131.408 1.00 89.50  ? 146 GLU B CB  1 
ATOM 5562 C CG  . GLU B 1 146 ? 116.949 75.006  130.566 1.00 89.08  ? 146 GLU B CG  1 
ATOM 5563 C CD  . GLU B 1 146 ? 115.666 74.820  131.354 1.00 88.78  ? 146 GLU B CD  1 
ATOM 5564 O OE1 . GLU B 1 146 ? 115.391 75.645  132.251 1.00 90.99  ? 146 GLU B OE1 1 
ATOM 5565 O OE2 . GLU B 1 146 ? 114.931 73.851  131.074 1.00 88.94  ? 146 GLU B OE2 1 
ATOM 5566 N N   . GLY B 1 147 ? 121.131 73.624  132.150 1.00 92.24  ? 147 GLY B N   1 
ATOM 5567 C CA  . GLY B 1 147 ? 122.178 73.764  133.154 1.00 90.11  ? 147 GLY B CA  1 
ATOM 5568 C C   . GLY B 1 147 ? 123.534 74.116  132.567 1.00 88.89  ? 147 GLY B C   1 
ATOM 5569 O O   . GLY B 1 147 ? 124.180 75.076  132.997 1.00 86.05  ? 147 GLY B O   1 
ATOM 5570 N N   . LEU B 1 148 ? 123.979 73.357  131.566 1.00 94.73  ? 148 LEU B N   1 
ATOM 5571 C CA  . LEU B 1 148 ? 125.302 73.613  131.007 1.00 95.32  ? 148 LEU B CA  1 
ATOM 5572 C C   . LEU B 1 148 ? 125.294 74.852  130.116 1.00 96.53  ? 148 LEU B C   1 
ATOM 5573 O O   . LEU B 1 148 ? 126.319 75.528  129.975 1.00 95.15  ? 148 LEU B O   1 
ATOM 5574 C CB  . LEU B 1 148 ? 125.805 72.373  130.263 1.00 92.78  ? 148 LEU B CB  1 
ATOM 5575 C CG  . LEU B 1 148 ? 125.309 71.984  128.870 1.00 92.14  ? 148 LEU B CG  1 
ATOM 5576 C CD1 . LEU B 1 148 ? 126.263 72.493  127.803 1.00 92.24  ? 148 LEU B CD1 1 
ATOM 5577 C CD2 . LEU B 1 148 ? 125.139 70.477  128.766 1.00 94.13  ? 148 LEU B CD2 1 
ATOM 5578 N N   . THR B 1 149 ? 124.142 75.181  129.522 1.00 93.35  ? 149 THR B N   1 
ATOM 5579 C CA  . THR B 1 149 ? 124.032 76.443  128.796 1.00 90.33  ? 149 THR B CA  1 
ATOM 5580 C C   . THR B 1 149 ? 124.095 77.631  129.748 1.00 88.97  ? 149 THR B C   1 
ATOM 5581 O O   . THR B 1 149 ? 124.688 78.665  129.421 1.00 88.91  ? 149 THR B O   1 
ATOM 5582 C CB  . THR B 1 149 ? 122.744 76.479  127.975 1.00 85.45  ? 149 THR B CB  1 
ATOM 5583 O OG1 . THR B 1 149 ? 122.530 75.200  127.365 1.00 89.46  ? 149 THR B OG1 1 
ATOM 5584 C CG2 . THR B 1 149 ? 122.841 77.536  126.886 1.00 86.34  ? 149 THR B CG2 1 
ATOM 5585 N N   . ALA B 1 150 ? 123.498 77.501  130.937 1.00 88.46  ? 150 ALA B N   1 
ATOM 5586 C CA  . ALA B 1 150 ? 123.662 78.526  131.963 1.00 87.75  ? 150 ALA B CA  1 
ATOM 5587 C C   . ALA B 1 150 ? 125.105 78.602  132.446 1.00 87.80  ? 150 ALA B C   1 
ATOM 5588 O O   . ALA B 1 150 ? 125.591 79.691  132.773 1.00 81.77  ? 150 ALA B O   1 
ATOM 5589 C CB  . ALA B 1 150 ? 122.720 78.255  133.135 1.00 89.92  ? 150 ALA B CB  1 
ATOM 5590 N N   . ASP B 1 151 ? 125.794 77.458  132.500 1.00 87.76  ? 151 ASP B N   1 
ATOM 5591 C CA  . ASP B 1 151 ? 127.218 77.452  132.827 1.00 91.40  ? 151 ASP B CA  1 
ATOM 5592 C C   . ASP B 1 151 ? 128.025 78.222  131.786 1.00 92.30  ? 151 ASP B C   1 
ATOM 5593 O O   . ASP B 1 151 ? 128.911 79.011  132.138 1.00 95.03  ? 151 ASP B O   1 
ATOM 5594 C CB  . ASP B 1 151 ? 127.718 76.011  132.941 1.00 90.40  ? 151 ASP B CB  1 
ATOM 5595 C CG  . ASP B 1 151 ? 129.220 75.888  132.744 1.00 90.77  ? 151 ASP B CG  1 
ATOM 5596 O OD1 . ASP B 1 151 ? 129.740 74.752  132.721 1.00 91.16  ? 151 ASP B OD1 1 
ATOM 5597 O OD2 . ASP B 1 151 ? 129.887 76.936  132.616 1.00 89.92  ? 151 ASP B OD2 1 
ATOM 5598 N N   . PHE B 1 152 ? 127.725 78.005  130.500 1.00 87.45  ? 152 PHE B N   1 
ATOM 5599 C CA  . PHE B 1 152 ? 128.371 78.761  129.427 1.00 89.27  ? 152 PHE B CA  1 
ATOM 5600 C C   . PHE B 1 152 ? 128.058 80.250  129.560 1.00 87.60  ? 152 PHE B C   1 
ATOM 5601 O O   . PHE B 1 152 ? 128.951 81.093  129.419 1.00 87.17  ? 152 PHE B O   1 
ATOM 5602 C CB  . PHE B 1 152 ? 127.911 78.206  128.066 1.00 89.14  ? 152 PHE B CB  1 
ATOM 5603 C CG  . PHE B 1 152 ? 128.278 79.054  126.844 1.00 90.41  ? 152 PHE B CG  1 
ATOM 5604 C CD1 . PHE B 1 152 ? 127.706 78.756  125.619 1.00 88.28  ? 152 PHE B CD1 1 
ATOM 5605 C CD2 . PHE B 1 152 ? 129.256 80.045  126.878 1.00 94.47  ? 152 PHE B CD2 1 
ATOM 5606 C CE1 . PHE B 1 152 ? 128.021 79.486  124.487 1.00 89.19  ? 152 PHE B CE1 1 
ATOM 5607 C CE2 . PHE B 1 152 ? 129.563 80.787  125.751 1.00 92.54  ? 152 PHE B CE2 1 
ATOM 5608 C CZ  . PHE B 1 152 ? 128.950 80.500  124.551 1.00 89.93  ? 152 PHE B CZ  1 
ATOM 5609 N N   . LEU B 1 153 ? 126.804 80.590  129.855 1.00 83.02  ? 153 LEU B N   1 
ATOM 5610 C CA  . LEU B 1 153 ? 126.429 81.996  129.958 1.00 85.41  ? 153 LEU B CA  1 
ATOM 5611 C C   . LEU B 1 153 ? 127.136 82.684  131.122 1.00 86.87  ? 153 LEU B C   1 
ATOM 5612 O O   . LEU B 1 153 ? 127.592 83.822  130.984 1.00 88.00  ? 153 LEU B O   1 
ATOM 5613 C CB  . LEU B 1 153 ? 124.913 82.130  130.085 1.00 87.34  ? 153 LEU B CB  1 
ATOM 5614 C CG  . LEU B 1 153 ? 124.284 83.291  129.310 1.00 86.52  ? 153 LEU B CG  1 
ATOM 5615 C CD1 . LEU B 1 153 ? 124.903 83.440  127.929 1.00 84.56  ? 153 LEU B CD1 1 
ATOM 5616 C CD2 . LEU B 1 153 ? 122.780 83.107  129.202 1.00 91.98  ? 153 LEU B CD2 1 
ATOM 5617 N N   . ARG B 1 154 ? 127.265 82.005  132.266 1.00 88.40  ? 154 ARG B N   1 
ATOM 5618 C CA  . ARG B 1 154 ? 127.966 82.611  133.398 1.00 90.60  ? 154 ARG B CA  1 
ATOM 5619 C C   . ARG B 1 154 ? 129.469 82.698  133.145 1.00 90.13  ? 154 ARG B C   1 
ATOM 5620 O O   . ARG B 1 154 ? 130.110 83.698  133.503 1.00 87.54  ? 154 ARG B O   1 
ATOM 5621 C CB  . ARG B 1 154 ? 127.681 81.827  134.680 1.00 88.70  ? 154 ARG B CB  1 
ATOM 5622 C CG  . ARG B 1 154 ? 126.516 82.368  135.505 1.00 89.91  ? 154 ARG B CG  1 
ATOM 5623 C CD  . ARG B 1 154 ? 126.732 83.800  136.001 1.00 88.26  ? 154 ARG B CD  1 
ATOM 5624 N NE  . ARG B 1 154 ? 128.119 84.108  136.333 1.00 87.58  ? 154 ARG B NE  1 
ATOM 5625 C CZ  . ARG B 1 154 ? 128.717 83.768  137.467 1.00 88.26  ? 154 ARG B CZ  1 
ATOM 5626 N NH1 . ARG B 1 154 ? 128.074 83.109  138.417 1.00 92.17  ? 154 ARG B NH1 1 
ATOM 5627 N NH2 . ARG B 1 154 ? 129.990 84.103  137.654 1.00 88.15  ? 154 ARG B NH2 1 
ATOM 5628 N N   . GLU B 1 155 ? 130.046 81.662  132.520 1.00 75.11  ? 155 GLU B N   1 
ATOM 5629 C CA  . GLU B 1 155 ? 131.449 81.678  132.119 1.00 68.07  ? 155 GLU B CA  1 
ATOM 5630 C C   . GLU B 1 155 ? 131.731 82.748  131.072 1.00 69.67  ? 155 GLU B C   1 
ATOM 5631 O O   . GLU B 1 155 ? 132.884 83.158  130.907 1.00 75.73  ? 155 GLU B O   1 
ATOM 5632 C CB  . GLU B 1 155 ? 131.838 80.292  131.593 1.00 69.11  ? 155 GLU B CB  1 
ATOM 5633 C CG  . GLU B 1 155 ? 133.328 79.981  131.595 1.00 73.11  ? 155 GLU B CG  1 
ATOM 5634 C CD  . GLU B 1 155 ? 133.798 79.390  130.278 1.00 72.86  ? 155 GLU B CD  1 
ATOM 5635 O OE1 . GLU B 1 155 ? 132.942 79.099  129.417 1.00 76.13  ? 155 GLU B OE1 1 
ATOM 5636 O OE2 . GLU B 1 155 ? 135.022 79.214  130.105 1.00 72.98  ? 155 GLU B OE2 1 
ATOM 5637 N N   . TYR B 1 156 ? 130.704 83.184  130.346 1.00 72.29  ? 156 TYR B N   1 
ATOM 5638 C CA  . TYR B 1 156 ? 130.810 84.366  129.501 1.00 74.03  ? 156 TYR B CA  1 
ATOM 5639 C C   . TYR B 1 156 ? 130.726 85.649  130.325 1.00 71.84  ? 156 TYR B C   1 
ATOM 5640 O O   . TYR B 1 156 ? 131.526 86.573  130.140 1.00 73.27  ? 156 TYR B O   1 
ATOM 5641 C CB  . TYR B 1 156 ? 129.701 84.351  128.450 1.00 75.75  ? 156 TYR B CB  1 
ATOM 5642 C CG  . TYR B 1 156 ? 129.974 85.249  127.278 1.00 72.50  ? 156 TYR B CG  1 
ATOM 5643 C CD1 . TYR B 1 156 ? 131.242 85.762  127.058 1.00 70.18  ? 156 TYR B CD1 1 
ATOM 5644 C CD2 . TYR B 1 156 ? 128.950 85.639  126.431 1.00 72.40  ? 156 TYR B CD2 1 
ATOM 5645 C CE1 . TYR B 1 156 ? 131.492 86.593  126.012 1.00 76.47  ? 156 TYR B CE1 1 
ATOM 5646 C CE2 . TYR B 1 156 ? 129.189 86.484  125.382 1.00 65.90  ? 156 TYR B CE2 1 
ATOM 5647 C CZ  . TYR B 1 156 ? 130.467 86.952  125.173 1.00 74.29  ? 156 TYR B CZ  1 
ATOM 5648 O OH  . TYR B 1 156 ? 130.744 87.794  124.128 1.00 69.16  ? 156 TYR B OH  1 
ATOM 5649 N N   . VAL B 1 157 ? 129.738 85.723  131.223 1.00 75.42  ? 157 VAL B N   1 
ATOM 5650 C CA  . VAL B 1 157 ? 129.448 86.933  131.989 1.00 78.07  ? 157 VAL B CA  1 
ATOM 5651 C C   . VAL B 1 157 ? 130.613 87.343  132.883 1.00 84.73  ? 157 VAL B C   1 
ATOM 5652 O O   . VAL B 1 157 ? 130.860 88.543  133.063 1.00 84.32  ? 157 VAL B O   1 
ATOM 5653 C CB  . VAL B 1 157 ? 128.133 86.717  132.782 1.00 79.99  ? 157 VAL B CB  1 
ATOM 5654 C CG1 . VAL B 1 157 ? 127.976 87.704  133.930 1.00 81.42  ? 157 VAL B CG1 1 
ATOM 5655 C CG2 . VAL B 1 157 ? 126.941 86.853  131.850 1.00 81.99  ? 157 VAL B CG2 1 
ATOM 5656 N N   . THR B 1 158 ? 131.396 86.378  133.383 1.00 79.12  ? 158 THR B N   1 
ATOM 5657 C CA  . THR B 1 158 ? 132.508 86.723  134.269 1.00 79.97  ? 158 THR B CA  1 
ATOM 5658 C C   . THR B 1 158 ? 133.625 87.491  133.561 1.00 78.79  ? 158 THR B C   1 
ATOM 5659 O O   . THR B 1 158 ? 134.515 88.016  134.238 1.00 81.95  ? 158 THR B O   1 
ATOM 5660 C CB  . THR B 1 158 ? 133.094 85.470  134.924 1.00 81.26  ? 158 THR B CB  1 
ATOM 5661 O OG1 . THR B 1 158 ? 134.347 85.796  135.538 1.00 79.23  ? 158 THR B OG1 1 
ATOM 5662 C CG2 . THR B 1 158 ? 133.329 84.392  133.892 1.00 78.09  ? 158 THR B CG2 1 
ATOM 5663 N N   . LEU B 1 159 ? 133.605 87.572  132.228 1.00 76.81  ? 159 LEU B N   1 
ATOM 5664 C CA  . LEU B 1 159 ? 134.543 88.422  131.507 1.00 78.64  ? 159 LEU B CA  1 
ATOM 5665 C C   . LEU B 1 159 ? 134.261 89.901  131.782 1.00 77.45  ? 159 LEU B C   1 
ATOM 5666 O O   . LEU B 1 159 ? 133.217 90.281  132.321 1.00 73.94  ? 159 LEU B O   1 
ATOM 5667 C CB  . LEU B 1 159 ? 134.480 88.158  130.002 1.00 74.99  ? 159 LEU B CB  1 
ATOM 5668 C CG  . LEU B 1 159 ? 135.263 86.980  129.419 1.00 76.65  ? 159 LEU B CG  1 
ATOM 5669 C CD1 . LEU B 1 159 ? 135.432 87.164  127.922 1.00 75.09  ? 159 LEU B CD1 1 
ATOM 5670 C CD2 . LEU B 1 159 ? 136.616 86.829  130.087 1.00 75.84  ? 159 LEU B CD2 1 
ATOM 5671 N N   . HIS B 1 160 ? 135.215 90.743  131.391 1.00 84.68  ? 160 HIS B N   1 
ATOM 5672 C CA  . HIS B 1 160 ? 135.179 92.171  131.668 1.00 83.43  ? 160 HIS B CA  1 
ATOM 5673 C C   . HIS B 1 160 ? 135.307 92.935  130.357 1.00 81.50  ? 160 HIS B C   1 
ATOM 5674 O O   . HIS B 1 160 ? 136.094 92.558  129.483 1.00 81.04  ? 160 HIS B O   1 
ATOM 5675 C CB  . HIS B 1 160 ? 136.290 92.537  132.672 1.00 82.40  ? 160 HIS B CB  1 
ATOM 5676 C CG  . HIS B 1 160 ? 136.568 94.003  132.804 1.00 83.37  ? 160 HIS B CG  1 
ATOM 5677 N ND1 . HIS B 1 160 ? 136.205 94.721  133.923 1.00 85.72  ? 160 HIS B ND1 1 
ATOM 5678 C CD2 . HIS B 1 160 ? 137.270 94.859  132.023 1.00 84.17  ? 160 HIS B CD2 1 
ATOM 5679 C CE1 . HIS B 1 160 ? 136.605 95.972  133.791 1.00 84.21  ? 160 HIS B CE1 1 
ATOM 5680 N NE2 . HIS B 1 160 ? 137.258 96.081  132.650 1.00 85.48  ? 160 HIS B NE2 1 
ATOM 5681 N N   . LYS B 1 161 ? 134.529 94.010  130.229 1.00 78.97  ? 161 LYS B N   1 
ATOM 5682 C CA  . LYS B 1 161 ? 134.356 94.728  128.970 1.00 81.97  ? 161 LYS B CA  1 
ATOM 5683 C C   . LYS B 1 161 ? 134.807 96.184  129.074 1.00 81.59  ? 161 LYS B C   1 
ATOM 5684 O O   . LYS B 1 161 ? 134.104 97.094  128.631 1.00 77.92  ? 161 LYS B O   1 
ATOM 5685 C CB  . LYS B 1 161 ? 132.900 94.647  128.511 1.00 77.14  ? 161 LYS B CB  1 
ATOM 5686 C CG  . LYS B 1 161 ? 131.894 95.118  129.553 1.00 75.68  ? 161 LYS B CG  1 
ATOM 5687 C CD  . LYS B 1 161 ? 130.515 94.535  129.301 1.00 76.42  ? 161 LYS B CD  1 
ATOM 5688 C CE  . LYS B 1 161 ? 130.413 93.119  129.840 1.00 76.58  ? 161 LYS B CE  1 
ATOM 5689 N NZ  . LYS B 1 161 ? 130.349 93.091  131.327 1.00 77.31  ? 161 LYS B NZ  1 
ATOM 5690 N N   . GLY B 1 162 ? 135.991 96.414  129.639 1.00 83.98  ? 162 GLY B N   1 
ATOM 5691 C CA  . GLY B 1 162 ? 136.471 97.755  129.916 1.00 84.20  ? 162 GLY B CA  1 
ATOM 5692 C C   . GLY B 1 162 ? 137.070 98.513  128.750 1.00 85.81  ? 162 GLY B C   1 
ATOM 5693 O O   . GLY B 1 162 ? 137.833 99.462  128.951 1.00 91.98  ? 162 GLY B O   1 
ATOM 5694 N N   . CYS B 1 163 ? 136.742 98.111  127.532 1.00 74.31  ? 163 CYS B N   1 
ATOM 5695 C CA  . CYS B 1 163 ? 137.360 98.678  126.343 1.00 71.31  ? 163 CYS B CA  1 
ATOM 5696 C C   . CYS B 1 163 ? 136.374 99.143  125.284 1.00 70.71  ? 163 CYS B C   1 
ATOM 5697 O O   . CYS B 1 163 ? 136.622 100.157 124.626 1.00 66.78  ? 163 CYS B O   1 
ATOM 5698 C CB  . CYS B 1 163 ? 138.312 97.646  125.747 1.00 66.31  ? 163 CYS B CB  1 
ATOM 5699 S SG  . CYS B 1 163 ? 137.455 96.174  125.198 1.00 80.29  ? 163 CYS B SG  1 
ATOM 5700 N N   . PHE B 1 164 ? 135.261 98.431  125.089 1.00 60.54  ? 164 PHE B N   1 
ATOM 5701 C CA  . PHE B 1 164 ? 134.288 98.829  124.079 1.00 48.75  ? 164 PHE B CA  1 
ATOM 5702 C C   . PHE B 1 164 ? 133.388 99.965  124.540 1.00 55.61  ? 164 PHE B C   1 
ATOM 5703 O O   . PHE B 1 164 ? 132.611 100.482 123.731 1.00 56.40  ? 164 PHE B O   1 
ATOM 5704 C CB  . PHE B 1 164 ? 133.398 97.651  123.675 1.00 46.31  ? 164 PHE B CB  1 
ATOM 5705 C CG  . PHE B 1 164 ? 134.081 96.319  123.707 1.00 50.42  ? 164 PHE B CG  1 
ATOM 5706 C CD1 . PHE B 1 164 ? 134.853 95.896  122.640 1.00 55.52  ? 164 PHE B CD1 1 
ATOM 5707 C CD2 . PHE B 1 164 ? 133.920 95.471  124.791 1.00 49.66  ? 164 PHE B CD2 1 
ATOM 5708 C CE1 . PHE B 1 164 ? 135.469 94.660  122.661 1.00 52.51  ? 164 PHE B CE1 1 
ATOM 5709 C CE2 . PHE B 1 164 ? 134.534 94.235  124.818 1.00 48.87  ? 164 PHE B CE2 1 
ATOM 5710 C CZ  . PHE B 1 164 ? 135.307 93.828  123.750 1.00 46.85  ? 164 PHE B CZ  1 
ATOM 5711 N N   . TYR B 1 165 ? 133.463 100.353 125.813 1.00 68.07  ? 165 TYR B N   1 
ATOM 5712 C CA  . TYR B 1 165 ? 132.553 101.334 126.391 1.00 64.84  ? 165 TYR B CA  1 
ATOM 5713 C C   . TYR B 1 165 ? 133.274 102.572 126.905 1.00 61.30  ? 165 TYR B C   1 
ATOM 5714 O O   . TYR B 1 165 ? 132.639 103.435 127.521 1.00 61.90  ? 165 TYR B O   1 
ATOM 5715 C CB  . TYR B 1 165 ? 131.744 100.688 127.518 1.00 65.33  ? 165 TYR B CB  1 
ATOM 5716 C CG  . TYR B 1 165 ? 130.684 99.727  127.028 1.00 65.23  ? 165 TYR B CG  1 
ATOM 5717 C CD1 . TYR B 1 165 ? 130.116 99.870  125.767 1.00 64.80  ? 165 TYR B CD1 1 
ATOM 5718 C CD2 . TYR B 1 165 ? 130.278 98.655  127.811 1.00 69.62  ? 165 TYR B CD2 1 
ATOM 5719 C CE1 . TYR B 1 165 ? 129.153 98.990  125.313 1.00 67.73  ? 165 TYR B CE1 1 
ATOM 5720 C CE2 . TYR B 1 165 ? 129.313 97.775  127.368 1.00 70.26  ? 165 TYR B CE2 1 
ATOM 5721 C CZ  . TYR B 1 165 ? 128.758 97.943  126.117 1.00 66.33  ? 165 TYR B CZ  1 
ATOM 5722 O OH  . TYR B 1 165 ? 127.802 97.062  125.672 1.00 60.28  ? 165 TYR B OH  1 
ATOM 5723 N N   . GLY B 1 166 ? 134.579 102.679 126.678 1.00 65.86  ? 166 GLY B N   1 
ATOM 5724 C CA  . GLY B 1 166 ? 135.322 103.855 127.080 1.00 69.67  ? 166 GLY B CA  1 
ATOM 5725 C C   . GLY B 1 166 ? 135.355 104.900 125.987 1.00 71.59  ? 166 GLY B C   1 
ATOM 5726 O O   . GLY B 1 166 ? 134.305 105.299 125.476 1.00 72.72  ? 166 GLY B O   1 
ATOM 5727 N N   . ARG B 1 167 ? 136.556 105.353 125.619 1.00 67.78  ? 167 ARG B N   1 
ATOM 5728 C CA  . ARG B 1 167 ? 136.684 106.324 124.537 1.00 69.43  ? 167 ARG B CA  1 
ATOM 5729 C C   . ARG B 1 167 ? 136.336 105.705 123.188 1.00 69.26  ? 167 ARG B C   1 
ATOM 5730 O O   . ARG B 1 167 ? 135.772 106.381 122.318 1.00 73.41  ? 167 ARG B O   1 
ATOM 5731 C CB  . ARG B 1 167 ? 138.101 106.905 124.533 1.00 68.66  ? 167 ARG B CB  1 
ATOM 5732 C CG  . ARG B 1 167 ? 138.614 107.415 123.188 1.00 69.53  ? 167 ARG B CG  1 
ATOM 5733 C CD  . ARG B 1 167 ? 139.877 108.219 123.377 1.00 67.69  ? 167 ARG B CD  1 
ATOM 5734 N NE  . ARG B 1 167 ? 140.649 107.680 124.486 1.00 68.83  ? 167 ARG B NE  1 
ATOM 5735 C CZ  . ARG B 1 167 ? 141.884 108.043 124.792 1.00 64.66  ? 167 ARG B CZ  1 
ATOM 5736 N NH1 . ARG B 1 167 ? 142.534 108.952 124.084 1.00 63.90  ? 167 ARG B NH1 1 
ATOM 5737 N NH2 . ARG B 1 167 ? 142.481 107.480 125.834 1.00 67.17  ? 167 ARG B NH2 1 
ATOM 5738 N N   . CYS B 1 168 ? 136.591 104.411 123.023 1.00 66.29  ? 168 CYS B N   1 
ATOM 5739 C CA  . CYS B 1 168 ? 136.389 103.716 121.753 1.00 68.60  ? 168 CYS B CA  1 
ATOM 5740 C C   . CYS B 1 168 ? 134.970 103.189 121.597 1.00 68.87  ? 168 CYS B C   1 
ATOM 5741 O O   . CYS B 1 168 ? 134.743 102.186 120.914 1.00 68.61  ? 168 CYS B O   1 
ATOM 5742 C CB  . CYS B 1 168 ? 137.401 102.582 121.633 1.00 68.51  ? 168 CYS B CB  1 
ATOM 5743 S SG  . CYS B 1 168 ? 137.867 102.182 119.943 1.00 84.75  ? 168 CYS B SG  1 
ATOM 5744 N N   . LEU B 1 169 ? 133.996 103.847 122.223 1.00 66.98  ? 169 LEU B N   1 
ATOM 5745 C CA  . LEU B 1 169 ? 132.605 103.402 122.209 1.00 68.26  ? 169 LEU B CA  1 
ATOM 5746 C C   . LEU B 1 169 ? 132.023 103.642 120.822 1.00 70.65  ? 169 LEU B C   1 
ATOM 5747 O O   . LEU B 1 169 ? 131.662 104.767 120.471 1.00 68.47  ? 169 LEU B O   1 
ATOM 5748 C CB  . LEU B 1 169 ? 131.809 104.128 123.287 1.00 64.99  ? 169 LEU B CB  1 
ATOM 5749 C CG  . LEU B 1 169 ? 130.401 103.646 123.637 1.00 68.28  ? 169 LEU B CG  1 
ATOM 5750 C CD1 . LEU B 1 169 ? 130.166 103.879 125.109 1.00 68.44  ? 169 LEU B CD1 1 
ATOM 5751 C CD2 . LEU B 1 169 ? 129.334 104.368 122.833 1.00 65.25  ? 169 LEU B CD2 1 
ATOM 5752 N N   . GLY B 1 170 ? 131.926 102.579 120.031 1.00 74.91  ? 170 GLY B N   1 
ATOM 5753 C CA  . GLY B 1 170 ? 131.298 102.671 118.730 1.00 71.87  ? 170 GLY B CA  1 
ATOM 5754 C C   . GLY B 1 170 ? 132.271 102.667 117.572 1.00 70.87  ? 170 GLY B C   1 
ATOM 5755 O O   . GLY B 1 170 ? 132.013 103.302 116.547 1.00 67.74  ? 170 GLY B O   1 
ATOM 5756 N N   . PHE B 1 171 ? 133.390 101.952 117.717 1.00 62.13  ? 171 PHE B N   1 
ATOM 5757 C CA  . PHE B 1 171 ? 134.357 101.875 116.627 1.00 60.34  ? 171 PHE B CA  1 
ATOM 5758 C C   . PHE B 1 171 ? 133.835 101.031 115.471 1.00 60.99  ? 171 PHE B C   1 
ATOM 5759 O O   . PHE B 1 171 ? 134.190 101.282 114.314 1.00 58.33  ? 171 PHE B O   1 
ATOM 5760 C CB  . PHE B 1 171 ? 135.710 101.371 117.173 1.00 56.48  ? 171 PHE B CB  1 
ATOM 5761 C CG  . PHE B 1 171 ? 135.800 99.870  117.433 1.00 56.52  ? 171 PHE B CG  1 
ATOM 5762 C CD1 . PHE B 1 171 ? 135.810 99.405  118.735 1.00 59.09  ? 171 PHE B CD1 1 
ATOM 5763 C CD2 . PHE B 1 171 ? 136.044 98.953  116.414 1.00 54.53  ? 171 PHE B CD2 1 
ATOM 5764 C CE1 . PHE B 1 171 ? 135.928 98.054  119.010 1.00 59.27  ? 171 PHE B CE1 1 
ATOM 5765 C CE2 . PHE B 1 171 ? 136.163 97.604  116.681 1.00 54.34  ? 171 PHE B CE2 1 
ATOM 5766 C CZ  . PHE B 1 171 ? 136.113 97.157  117.982 1.00 58.72  ? 171 PHE B CZ  1 
ATOM 5767 N N   . GLN B 1 172 ? 132.994 100.036 115.761 1.00 64.89  ? 172 GLN B N   1 
ATOM 5768 C CA  . GLN B 1 172 ? 132.549 99.107  114.729 1.00 63.16  ? 172 GLN B CA  1 
ATOM 5769 C C   . GLN B 1 172 ? 131.548 99.733  113.768 1.00 68.63  ? 172 GLN B C   1 
ATOM 5770 O O   . GLN B 1 172 ? 131.305 99.169  112.696 1.00 69.32  ? 172 GLN B O   1 
ATOM 5771 C CB  . GLN B 1 172 ? 131.937 97.859  115.370 1.00 61.28  ? 172 GLN B CB  1 
ATOM 5772 C CG  . GLN B 1 172 ? 130.743 98.132  116.267 1.00 60.41  ? 172 GLN B CG  1 
ATOM 5773 C CD  . GLN B 1 172 ? 131.096 98.141  117.739 1.00 54.33  ? 172 GLN B CD  1 
ATOM 5774 O OE1 . GLN B 1 172 ? 131.858 98.986  118.200 1.00 53.89  ? 172 GLN B OE1 1 
ATOM 5775 N NE2 . GLN B 1 172 ? 130.537 97.198  118.487 1.00 52.03  ? 172 GLN B NE2 1 
ATOM 5776 N N   . PHE B 1 173 ? 130.970 100.878 114.119 1.00 66.04  ? 173 PHE B N   1 
ATOM 5777 C CA  . PHE B 1 173 ? 129.974 101.544 113.298 1.00 57.64  ? 173 PHE B CA  1 
ATOM 5778 C C   . PHE B 1 173 ? 130.621 102.639 112.456 1.00 59.20  ? 173 PHE B C   1 
ATOM 5779 O O   . PHE B 1 173 ? 131.841 102.809 112.428 1.00 67.43  ? 173 PHE B O   1 
ATOM 5780 C CB  . PHE B 1 173 ? 128.865 102.132 114.171 1.00 59.78  ? 173 PHE B CB  1 
ATOM 5781 C CG  . PHE B 1 173 ? 128.331 101.177 115.187 1.00 64.38  ? 173 PHE B CG  1 
ATOM 5782 C CD1 . PHE B 1 173 ? 127.535 100.111 114.804 1.00 64.99  ? 173 PHE B CD1 1 
ATOM 5783 C CD2 . PHE B 1 173 ? 128.628 101.341 116.526 1.00 63.15  ? 173 PHE B CD2 1 
ATOM 5784 C CE1 . PHE B 1 173 ? 127.045 99.229  115.742 1.00 62.73  ? 173 PHE B CE1 1 
ATOM 5785 C CE2 . PHE B 1 173 ? 128.144 100.464 117.464 1.00 60.75  ? 173 PHE B CE2 1 
ATOM 5786 C CZ  . PHE B 1 173 ? 127.349 99.407  117.075 1.00 63.85  ? 173 PHE B CZ  1 
ATOM 5787 N N   . THR B 1 174 ? 129.775 103.383 111.755 1.00 63.96  ? 174 THR B N   1 
ATOM 5788 C CA  . THR B 1 174 ? 130.228 104.559 111.032 1.00 74.45  ? 174 THR B CA  1 
ATOM 5789 C C   . THR B 1 174 ? 130.646 105.643 112.026 1.00 77.12  ? 174 THR B C   1 
ATOM 5790 O O   . THR B 1 174 ? 130.032 105.776 113.089 1.00 77.85  ? 174 THR B O   1 
ATOM 5791 C CB  . THR B 1 174 ? 129.109 105.071 110.123 1.00 73.34  ? 174 THR B CB  1 
ATOM 5792 O OG1 . THR B 1 174 ? 128.351 103.957 109.636 1.00 72.72  ? 174 THR B OG1 1 
ATOM 5793 C CG2 . THR B 1 174 ? 129.668 105.837 108.933 1.00 75.53  ? 174 THR B CG2 1 
ATOM 5794 N N   . PRO B 1 175 ? 131.705 106.404 111.731 1.00 74.72  ? 175 PRO B N   1 
ATOM 5795 C CA  . PRO B 1 175 ? 132.089 107.507 112.630 1.00 73.11  ? 175 PRO B CA  1 
ATOM 5796 C C   . PRO B 1 175 ? 131.050 108.613 112.752 1.00 72.96  ? 175 PRO B C   1 
ATOM 5797 O O   . PRO B 1 175 ? 131.067 109.342 113.752 1.00 73.82  ? 175 PRO B O   1 
ATOM 5798 C CB  . PRO B 1 175 ? 133.388 108.031 112.005 1.00 75.33  ? 175 PRO B CB  1 
ATOM 5799 C CG  . PRO B 1 175 ? 133.949 106.863 111.284 1.00 73.15  ? 175 PRO B CG  1 
ATOM 5800 C CD  . PRO B 1 175 ? 132.771 106.094 110.761 1.00 69.46  ? 175 PRO B CD  1 
ATOM 5801 N N   . ALA B 1 176 ? 130.148 108.762 111.776 1.00 73.69  ? 176 ALA B N   1 
ATOM 5802 C CA  . ALA B 1 176 ? 129.133 109.811 111.847 1.00 80.34  ? 176 ALA B CA  1 
ATOM 5803 C C   . ALA B 1 176 ? 128.110 109.536 112.938 1.00 74.69  ? 176 ALA B C   1 
ATOM 5804 O O   . ALA B 1 176 ? 127.435 110.457 113.409 1.00 73.39  ? 176 ALA B O   1 
ATOM 5805 C CB  . ALA B 1 176 ? 128.429 109.950 110.500 1.00 79.11  ? 176 ALA B CB  1 
ATOM 5806 N N   . ILE B 1 177 ? 127.986 108.281 113.347 1.00 68.51  ? 177 ILE B N   1 
ATOM 5807 C CA  . ILE B 1 177 ? 127.007 107.883 114.341 1.00 71.71  ? 177 ILE B CA  1 
ATOM 5808 C C   . ILE B 1 177 ? 127.551 107.964 115.769 1.00 74.31  ? 177 ILE B C   1 
ATOM 5809 O O   . ILE B 1 177 ? 126.766 108.188 116.703 1.00 65.74  ? 177 ILE B O   1 
ATOM 5810 C CB  . ILE B 1 177 ? 126.506 106.496 113.879 1.00 71.28  ? 177 ILE B CB  1 
ATOM 5811 C CG1 . ILE B 1 177 ? 125.294 106.633 112.952 1.00 69.80  ? 177 ILE B CG1 1 
ATOM 5812 C CG2 . ILE B 1 177 ? 126.304 105.516 114.972 1.00 64.90  ? 177 ILE B CG2 1 
ATOM 5813 C CD1 . ILE B 1 177 ? 124.955 105.369 112.210 1.00 67.69  ? 177 ILE B CD1 1 
ATOM 5814 N N   . ARG B 1 178 ? 128.877 107.886 115.944 1.00 77.08  ? 178 ARG B N   1 
ATOM 5815 C CA  . ARG B 1 178 ? 129.501 107.849 117.271 1.00 71.06  ? 178 ARG B CA  1 
ATOM 5816 C C   . ARG B 1 178 ? 129.208 109.022 118.216 1.00 69.71  ? 178 ARG B C   1 
ATOM 5817 O O   . ARG B 1 178 ? 129.106 108.766 119.431 1.00 68.05  ? 178 ARG B O   1 
ATOM 5818 C CB  . ARG B 1 178 ? 131.022 107.693 117.108 1.00 63.74  ? 178 ARG B CB  1 
ATOM 5819 C CG  . ARG B 1 178 ? 131.439 106.603 116.139 1.00 63.41  ? 178 ARG B CG  1 
ATOM 5820 C CD  . ARG B 1 178 ? 132.951 106.387 116.131 1.00 70.36  ? 178 ARG B CD  1 
ATOM 5821 N NE  . ARG B 1 178 ? 133.703 107.604 116.414 1.00 75.44  ? 178 ARG B NE  1 
ATOM 5822 C CZ  . ARG B 1 178 ? 134.938 107.626 116.897 1.00 75.65  ? 178 ARG B CZ  1 
ATOM 5823 N NH1 . ARG B 1 178 ? 135.600 106.510 117.156 1.00 67.00  ? 178 ARG B NH1 1 
ATOM 5824 N NH2 . ARG B 1 178 ? 135.528 108.798 117.118 1.00 73.21  ? 178 ARG B NH2 1 
ATOM 5825 N N   . PRO B 1 179 ? 129.143 110.298 117.783 1.00 73.51  ? 179 PRO B N   1 
ATOM 5826 C CA  . PRO B 1 179 ? 128.788 111.354 118.755 1.00 72.17  ? 179 PRO B CA  1 
ATOM 5827 C C   . PRO B 1 179 ? 127.426 111.169 119.406 1.00 72.18  ? 179 PRO B C   1 
ATOM 5828 O O   . PRO B 1 179 ? 127.279 111.448 120.605 1.00 72.09  ? 179 PRO B O   1 
ATOM 5829 C CB  . PRO B 1 179 ? 128.849 112.639 117.914 1.00 70.26  ? 179 PRO B CB  1 
ATOM 5830 C CG  . PRO B 1 179 ? 128.791 112.191 116.501 1.00 68.76  ? 179 PRO B CG  1 
ATOM 5831 C CD  . PRO B 1 179 ? 129.539 110.907 116.498 1.00 74.21  ? 179 PRO B CD  1 
ATOM 5832 N N   . PHE B 1 180 ? 126.434 110.686 118.652 1.00 73.41  ? 180 PHE B N   1 
ATOM 5833 C CA  . PHE B 1 180 ? 125.117 110.425 119.225 1.00 71.65  ? 180 PHE B CA  1 
ATOM 5834 C C   . PHE B 1 180 ? 125.189 109.331 120.279 1.00 75.35  ? 180 PHE B C   1 
ATOM 5835 O O   . PHE B 1 180 ? 124.516 109.416 121.307 1.00 74.03  ? 180 PHE B O   1 
ATOM 5836 C CB  . PHE B 1 180 ? 124.118 110.100 118.100 1.00 71.79  ? 180 PHE B CB  1 
ATOM 5837 C CG  . PHE B 1 180 ? 122.744 109.658 118.572 1.00 71.86  ? 180 PHE B CG  1 
ATOM 5838 C CD1 . PHE B 1 180 ? 122.583 108.429 119.182 1.00 69.52  ? 180 PHE B CD1 1 
ATOM 5839 C CD2 . PHE B 1 180 ? 121.666 110.541 118.591 1.00 74.92  ? 180 PHE B CD2 1 
ATOM 5840 C CE1 . PHE B 1 180 ? 121.343 108.026 119.646 1.00 71.75  ? 180 PHE B CE1 1 
ATOM 5841 C CE2 . PHE B 1 180 ? 120.435 110.151 119.066 1.00 76.45  ? 180 PHE B CE2 1 
ATOM 5842 C CZ  . PHE B 1 180 ? 120.273 108.895 119.602 1.00 72.60  ? 180 PHE B CZ  1 
ATOM 5843 N N   . LEU B 1 181 ? 125.995 108.299 120.038 1.00 72.55  ? 181 LEU B N   1 
ATOM 5844 C CA  . LEU B 1 181 ? 126.232 107.268 121.048 1.00 67.89  ? 181 LEU B CA  1 
ATOM 5845 C C   . LEU B 1 181 ? 126.958 107.810 122.264 1.00 67.31  ? 181 LEU B C   1 
ATOM 5846 O O   . LEU B 1 181 ? 126.713 107.346 123.381 1.00 63.89  ? 181 LEU B O   1 
ATOM 5847 C CB  . LEU B 1 181 ? 126.989 106.084 120.445 1.00 71.83  ? 181 LEU B CB  1 
ATOM 5848 C CG  . LEU B 1 181 ? 126.314 105.091 119.497 1.00 73.52  ? 181 LEU B CG  1 
ATOM 5849 C CD1 . LEU B 1 181 ? 125.593 105.663 118.343 1.00 65.67  ? 181 LEU B CD1 1 
ATOM 5850 C CD2 . LEU B 1 181 ? 127.462 104.275 118.937 1.00 71.76  ? 181 LEU B CD2 1 
ATOM 5851 N N   . GLN B 1 182 ? 127.844 108.786 122.080 1.00 74.86  ? 182 GLN B N   1 
ATOM 5852 C CA  . GLN B 1 182 ? 128.493 109.388 123.240 1.00 77.86  ? 182 GLN B CA  1 
ATOM 5853 C C   . GLN B 1 182 ? 127.487 110.149 124.103 1.00 77.55  ? 182 GLN B C   1 
ATOM 5854 O O   . GLN B 1 182 ? 127.447 109.966 125.328 1.00 78.39  ? 182 GLN B O   1 
ATOM 5855 C CB  . GLN B 1 182 ? 129.637 110.287 122.780 1.00 71.25  ? 182 GLN B CB  1 
ATOM 5856 C CG  . GLN B 1 182 ? 130.904 109.503 122.473 1.00 73.85  ? 182 GLN B CG  1 
ATOM 5857 C CD  . GLN B 1 182 ? 131.761 110.155 121.415 1.00 75.63  ? 182 GLN B CD  1 
ATOM 5858 O OE1 . GLN B 1 182 ? 131.382 111.170 120.835 1.00 72.66  ? 182 GLN B OE1 1 
ATOM 5859 N NE2 . GLN B 1 182 ? 132.920 109.565 121.144 1.00 75.23  ? 182 GLN B NE2 1 
ATOM 5860 N N   . THR B 1 183 ? 126.633 110.970 123.477 1.00 70.56  ? 183 THR B N   1 
ATOM 5861 C CA  . THR B 1 183 ? 125.592 111.662 124.244 1.00 67.95  ? 183 THR B CA  1 
ATOM 5862 C C   . THR B 1 183 ? 124.564 110.691 124.815 1.00 69.33  ? 183 THR B C   1 
ATOM 5863 O O   . THR B 1 183 ? 124.023 110.921 125.902 1.00 71.21  ? 183 THR B O   1 
ATOM 5864 C CB  . THR B 1 183 ? 124.884 112.729 123.404 1.00 73.07  ? 183 THR B CB  1 
ATOM 5865 O OG1 . THR B 1 183 ? 123.771 112.148 122.711 1.00 71.26  ? 183 THR B OG1 1 
ATOM 5866 C CG2 . THR B 1 183 ? 125.825 113.429 122.452 1.00 71.79  ? 183 THR B CG2 1 
ATOM 5867 N N   . ILE B 1 184 ? 124.287 109.596 124.106 1.00 69.58  ? 184 ILE B N   1 
ATOM 5868 C CA  . ILE B 1 184 ? 123.370 108.584 124.618 1.00 71.94  ? 184 ILE B CA  1 
ATOM 5869 C C   . ILE B 1 184 ? 123.953 107.922 125.858 1.00 70.94  ? 184 ILE B C   1 
ATOM 5870 O O   . ILE B 1 184 ? 123.260 107.752 126.865 1.00 62.99  ? 184 ILE B O   1 
ATOM 5871 C CB  . ILE B 1 184 ? 123.032 107.570 123.506 1.00 71.62  ? 184 ILE B CB  1 
ATOM 5872 C CG1 . ILE B 1 184 ? 122.114 108.219 122.472 1.00 68.16  ? 184 ILE B CG1 1 
ATOM 5873 C CG2 . ILE B 1 184 ? 122.408 106.297 124.053 1.00 69.03  ? 184 ILE B CG2 1 
ATOM 5874 C CD1 . ILE B 1 184 ? 120.676 108.366 122.927 1.00 66.22  ? 184 ILE B CD1 1 
ATOM 5875 N N   . SER B 1 185 ? 125.248 107.591 125.821 1.00 71.94  ? 185 SER B N   1 
ATOM 5876 C CA  . SER B 1 185 ? 125.926 106.999 126.969 1.00 72.45  ? 185 SER B CA  1 
ATOM 5877 C C   . SER B 1 185 ? 125.950 107.949 128.156 1.00 74.40  ? 185 SER B C   1 
ATOM 5878 O O   . SER B 1 185 ? 125.787 107.514 129.305 1.00 72.89  ? 185 SER B O   1 
ATOM 5879 C CB  . SER B 1 185 ? 127.350 106.616 126.579 1.00 73.40  ? 185 SER B CB  1 
ATOM 5880 O OG  . SER B 1 185 ? 127.419 105.268 126.165 1.00 72.74  ? 185 SER B OG  1 
ATOM 5881 N N   . ILE B 1 186 ? 126.150 109.243 127.893 1.00 79.28  ? 186 ILE B N   1 
ATOM 5882 C CA  . ILE B 1 186 ? 126.034 110.247 128.949 1.00 80.02  ? 186 ILE B CA  1 
ATOM 5883 C C   . ILE B 1 186 ? 124.610 110.274 129.500 1.00 78.40  ? 186 ILE B C   1 
ATOM 5884 O O   . ILE B 1 186 ? 124.395 110.422 130.712 1.00 75.00  ? 186 ILE B O   1 
ATOM 5885 C CB  . ILE B 1 186 ? 126.494 111.621 128.426 1.00 77.35  ? 186 ILE B CB  1 
ATOM 5886 C CG1 . ILE B 1 186 ? 127.992 111.581 128.121 1.00 76.08  ? 186 ILE B CG1 1 
ATOM 5887 C CG2 . ILE B 1 186 ? 126.223 112.714 129.442 1.00 79.34  ? 186 ILE B CG2 1 
ATOM 5888 C CD1 . ILE B 1 186 ? 128.428 112.523 127.028 1.00 76.94  ? 186 ILE B CD1 1 
ATOM 5889 N N   . GLY B 1 187 ? 123.620 110.080 128.623 1.00 72.41  ? 187 GLY B N   1 
ATOM 5890 C CA  . GLY B 1 187 ? 122.239 109.983 129.070 1.00 71.29  ? 187 GLY B CA  1 
ATOM 5891 C C   . GLY B 1 187 ? 121.989 108.807 129.998 1.00 74.75  ? 187 GLY B C   1 
ATOM 5892 O O   . GLY B 1 187 ? 121.357 108.964 131.045 1.00 75.92  ? 187 GLY B O   1 
ATOM 5893 N N   . LEU B 1 188 ? 122.495 107.617 129.637 1.00 73.04  ? 188 LEU B N   1 
ATOM 5894 C CA  . LEU B 1 188 ? 122.333 106.467 130.533 1.00 77.38  ? 188 LEU B CA  1 
ATOM 5895 C C   . LEU B 1 188 ? 123.081 106.643 131.845 1.00 78.04  ? 188 LEU B C   1 
ATOM 5896 O O   . LEU B 1 188 ? 122.570 106.239 132.892 1.00 75.95  ? 188 LEU B O   1 
ATOM 5897 C CB  . LEU B 1 188 ? 122.748 105.119 129.923 1.00 74.25  ? 188 LEU B CB  1 
ATOM 5898 C CG  . LEU B 1 188 ? 122.291 104.316 128.694 1.00 72.63  ? 188 LEU B CG  1 
ATOM 5899 C CD1 . LEU B 1 188 ? 122.467 104.940 127.361 1.00 72.07  ? 188 LEU B CD1 1 
ATOM 5900 C CD2 . LEU B 1 188 ? 122.982 102.955 128.722 1.00 74.61  ? 188 LEU B CD2 1 
ATOM 5901 N N   . VAL B 1 189 ? 124.296 107.200 131.827 1.00 80.55  ? 189 VAL B N   1 
ATOM 5902 C CA  . VAL B 1 189 ? 125.023 107.293 133.093 1.00 81.10  ? 189 VAL B CA  1 
ATOM 5903 C C   . VAL B 1 189 ? 124.385 108.338 134.008 1.00 80.66  ? 189 VAL B C   1 
ATOM 5904 O O   . VAL B 1 189 ? 124.285 108.131 135.226 1.00 81.74  ? 189 VAL B O   1 
ATOM 5905 C CB  . VAL B 1 189 ? 126.533 107.525 132.873 1.00 77.59  ? 189 VAL B CB  1 
ATOM 5906 C CG1 . VAL B 1 189 ? 127.136 106.357 132.104 1.00 79.61  ? 189 VAL B CG1 1 
ATOM 5907 C CG2 . VAL B 1 189 ? 126.823 108.823 132.173 1.00 81.35  ? 189 VAL B CG2 1 
ATOM 5908 N N   . SER B 1 190 ? 123.888 109.443 133.436 1.00 73.91  ? 190 SER B N   1 
ATOM 5909 C CA  . SER B 1 190 ? 123.154 110.424 134.229 1.00 77.80  ? 190 SER B CA  1 
ATOM 5910 C C   . SER B 1 190 ? 121.849 109.844 134.766 1.00 80.80  ? 190 SER B C   1 
ATOM 5911 O O   . SER B 1 190 ? 121.504 110.062 135.936 1.00 83.59  ? 190 SER B O   1 
ATOM 5912 C CB  . SER B 1 190 ? 122.889 111.671 133.389 1.00 82.27  ? 190 SER B CB  1 
ATOM 5913 O OG  . SER B 1 190 ? 122.539 111.319 132.063 1.00 86.06  ? 190 SER B OG  1 
ATOM 5914 N N   . PHE B 1 191 ? 121.123 109.088 133.932 1.00 77.44  ? 191 PHE B N   1 
ATOM 5915 C CA  . PHE B 1 191 ? 119.894 108.439 134.378 1.00 79.13  ? 191 PHE B CA  1 
ATOM 5916 C C   . PHE B 1 191 ? 120.170 107.437 135.490 1.00 81.80  ? 191 PHE B C   1 
ATOM 5917 O O   . PHE B 1 191 ? 119.419 107.365 136.469 1.00 86.17  ? 191 PHE B O   1 
ATOM 5918 C CB  . PHE B 1 191 ? 119.217 107.739 133.200 1.00 81.77  ? 191 PHE B CB  1 
ATOM 5919 C CG  . PHE B 1 191 ? 118.114 108.534 132.565 1.00 79.93  ? 191 PHE B CG  1 
ATOM 5920 C CD1 . PHE B 1 191 ? 118.347 109.813 132.086 1.00 80.89  ? 191 PHE B CD1 1 
ATOM 5921 C CD2 . PHE B 1 191 ? 116.841 107.997 132.443 1.00 77.32  ? 191 PHE B CD2 1 
ATOM 5922 C CE1 . PHE B 1 191 ? 117.327 110.543 131.498 1.00 86.09  ? 191 PHE B CE1 1 
ATOM 5923 C CE2 . PHE B 1 191 ? 115.819 108.720 131.858 1.00 78.77  ? 191 PHE B CE2 1 
ATOM 5924 C CZ  . PHE B 1 191 ? 116.062 109.994 131.385 1.00 83.36  ? 191 PHE B CZ  1 
ATOM 5925 N N   . GLY B 1 192 ? 121.252 106.668 135.358 1.00 77.07  ? 192 GLY B N   1 
ATOM 5926 C CA  . GLY B 1 192 ? 121.579 105.673 136.364 1.00 79.36  ? 192 GLY B CA  1 
ATOM 5927 C C   . GLY B 1 192 ? 121.960 106.290 137.694 1.00 79.75  ? 192 GLY B C   1 
ATOM 5928 O O   . GLY B 1 192 ? 121.517 105.830 138.750 1.00 78.97  ? 192 GLY B O   1 
ATOM 5929 N N   . GLU B 1 193 ? 122.772 107.353 137.666 1.00 80.50  ? 193 GLU B N   1 
ATOM 5930 C CA  . GLU B 1 193 ? 123.146 107.982 138.929 1.00 78.81  ? 193 GLU B CA  1 
ATOM 5931 C C   . GLU B 1 193 ? 121.975 108.728 139.565 1.00 78.80  ? 193 GLU B C   1 
ATOM 5932 O O   . GLU B 1 193 ? 121.868 108.752 140.799 1.00 81.46  ? 193 GLU B O   1 
ATOM 5933 C CB  . GLU B 1 193 ? 124.360 108.902 138.738 1.00 79.18  ? 193 GLU B CB  1 
ATOM 5934 C CG  . GLU B 1 193 ? 124.187 110.088 137.797 1.00 83.13  ? 193 GLU B CG  1 
ATOM 5935 C CD  . GLU B 1 193 ? 123.629 111.321 138.482 1.00 82.43  ? 193 GLU B CD  1 
ATOM 5936 O OE1 . GLU B 1 193 ? 124.119 111.666 139.578 1.00 84.27  ? 193 GLU B OE1 1 
ATOM 5937 O OE2 . GLU B 1 193 ? 122.702 111.943 137.923 1.00 81.11  ? 193 GLU B OE2 1 
ATOM 5938 N N   . HIS B 1 194 ? 121.079 109.311 138.757 1.00 82.25  ? 194 HIS B N   1 
ATOM 5939 C CA  . HIS B 1 194 ? 119.898 109.963 139.317 1.00 82.68  ? 194 HIS B CA  1 
ATOM 5940 C C   . HIS B 1 194 ? 118.959 108.931 139.933 1.00 88.87  ? 194 HIS B C   1 
ATOM 5941 O O   . HIS B 1 194 ? 118.448 109.134 141.040 1.00 93.81  ? 194 HIS B O   1 
ATOM 5942 C CB  . HIS B 1 194 ? 119.198 110.782 138.221 1.00 81.52  ? 194 HIS B CB  1 
ATOM 5943 C CG  . HIS B 1 194 ? 117.797 111.217 138.547 1.00 84.97  ? 194 HIS B CG  1 
ATOM 5944 N ND1 . HIS B 1 194 ? 116.849 111.430 137.569 1.00 85.01  ? 194 HIS B ND1 1 
ATOM 5945 C CD2 . HIS B 1 194 ? 117.211 111.576 139.717 1.00 85.04  ? 194 HIS B CD2 1 
ATOM 5946 C CE1 . HIS B 1 194 ? 115.723 111.836 138.127 1.00 87.63  ? 194 HIS B CE1 1 
ATOM 5947 N NE2 . HIS B 1 194 ? 115.916 111.935 139.430 1.00 88.14  ? 194 HIS B NE2 1 
ATOM 5948 N N   . TYR B 1 195 ? 118.760 107.797 139.254 1.00 89.69  ? 195 TYR B N   1 
ATOM 5949 C CA  . TYR B 1 195 ? 117.863 106.770 139.766 1.00 86.52  ? 195 TYR B CA  1 
ATOM 5950 C C   . TYR B 1 195 ? 118.446 106.061 140.982 1.00 86.07  ? 195 TYR B C   1 
ATOM 5951 O O   . TYR B 1 195 ? 117.690 105.612 141.850 1.00 86.78  ? 195 TYR B O   1 
ATOM 5952 C CB  . TYR B 1 195 ? 117.536 105.762 138.662 1.00 82.22  ? 195 TYR B CB  1 
ATOM 5953 C CG  . TYR B 1 195 ? 116.085 105.339 138.656 1.00 82.52  ? 195 TYR B CG  1 
ATOM 5954 C CD1 . TYR B 1 195 ? 115.094 106.207 138.217 1.00 86.92  ? 195 TYR B CD1 1 
ATOM 5955 C CD2 . TYR B 1 195 ? 115.705 104.078 139.098 1.00 83.93  ? 195 TYR B CD2 1 
ATOM 5956 C CE1 . TYR B 1 195 ? 113.762 105.831 138.215 1.00 91.12  ? 195 TYR B CE1 1 
ATOM 5957 C CE2 . TYR B 1 195 ? 114.374 103.691 139.099 1.00 86.28  ? 195 TYR B CE2 1 
ATOM 5958 C CZ  . TYR B 1 195 ? 113.408 104.572 138.656 1.00 90.18  ? 195 TYR B CZ  1 
ATOM 5959 O OH  . TYR B 1 195 ? 112.083 104.196 138.655 1.00 88.34  ? 195 TYR B OH  1 
ATOM 5960 N N   . LYS B 1 196 ? 119.775 105.955 141.065 1.00 87.76  ? 196 LYS B N   1 
ATOM 5961 C CA  . LYS B 1 196 ? 120.396 105.442 142.281 1.00 85.39  ? 196 LYS B CA  1 
ATOM 5962 C C   . LYS B 1 196 ? 120.267 106.439 143.427 0.20 86.21  ? 196 LYS B C   1 
ATOM 5963 O O   . LYS B 1 196 ? 120.003 106.047 144.569 1.00 85.83  ? 196 LYS B O   1 
ATOM 5964 C CB  . LYS B 1 196 ? 121.864 105.106 142.020 1.00 85.35  ? 196 LYS B CB  1 
ATOM 5965 C CG  . LYS B 1 196 ? 122.517 104.283 143.120 1.00 87.81  ? 196 LYS B CG  1 
ATOM 5966 C CD  . LYS B 1 196 ? 123.491 105.116 143.938 1.00 85.20  ? 196 LYS B CD  1 
ATOM 5967 C CE  . LYS B 1 196 ? 123.655 104.550 145.339 1.00 86.40  ? 196 LYS B CE  1 
ATOM 5968 N NZ  . LYS B 1 196 ? 124.692 105.281 146.117 1.00 85.81  ? 196 LYS B NZ  1 
ATOM 5969 N N   . ARG B 1 197 ? 120.448 107.731 143.144 1.00 84.73  ? 197 ARG B N   1 
ATOM 5970 C CA  . ARG B 1 197 ? 120.317 108.750 144.177 1.00 83.39  ? 197 ARG B CA  1 
ATOM 5971 C C   . ARG B 1 197 ? 118.869 109.126 144.463 1.00 83.85  ? 197 ARG B C   1 
ATOM 5972 O O   . ARG B 1 197 ? 118.618 109.798 145.471 1.00 84.72  ? 197 ARG B O   1 
ATOM 5973 C CB  . ARG B 1 197 ? 121.107 110.002 143.786 1.00 84.67  ? 197 ARG B CB  1 
ATOM 5974 C CG  . ARG B 1 197 ? 122.609 109.868 143.987 1.00 84.66  ? 197 ARG B CG  1 
ATOM 5975 C CD  . ARG B 1 197 ? 123.266 111.218 144.222 1.00 84.53  ? 197 ARG B CD  1 
ATOM 5976 N NE  . ARG B 1 197 ? 124.407 111.111 145.123 1.00 85.98  ? 197 ARG B NE  1 
ATOM 5977 C CZ  . ARG B 1 197 ? 124.856 112.098 145.886 1.00 86.98  ? 197 ARG B CZ  1 
ATOM 5978 N NH1 . ARG B 1 197 ? 124.285 113.291 145.878 1.00 84.87  ? 197 ARG B NH1 1 
ATOM 5979 N NH2 . ARG B 1 197 ? 125.903 111.882 146.677 1.00 87.09  ? 197 ARG B NH2 1 
ATOM 5980 N N   . ASN B 1 198 ? 117.933 108.710 143.606 1.00 85.66  ? 198 ASN B N   1 
ATOM 5981 C CA  . ASN B 1 198 ? 116.492 108.958 143.748 1.00 86.42  ? 198 ASN B CA  1 
ATOM 5982 C C   . ASN B 1 198 ? 116.148 110.441 143.888 1.00 85.17  ? 198 ASN B C   1 
ATOM 5983 O O   . ASN B 1 198 ? 114.982 110.827 143.806 1.00 84.79  ? 198 ASN B O   1 
ATOM 5984 C CB  . ASN B 1 198 ? 115.926 108.176 144.940 1.00 86.63  ? 198 ASN B CB  1 
ATOM 5985 C CG  . ASN B 1 198 ? 115.692 106.713 144.618 1.00 86.98  ? 198 ASN B CG  1 
ATOM 5986 O OD1 . ASN B 1 198 ? 116.622 105.907 144.631 1.00 85.47  ? 198 ASN B OD1 1 
ATOM 5987 N ND2 . ASN B 1 198 ? 114.445 106.363 144.325 1.00 85.18  ? 198 ASN B ND2 1 
ATOM 5988 N N   . ARG B 1 214 ? 129.572 116.186 133.211 1.00 99.97  ? 214 ARG B N   1 
ATOM 5989 C CA  . ARG B 1 214 ? 130.718 115.808 134.029 1.00 101.18 ? 214 ARG B CA  1 
ATOM 5990 C C   . ARG B 1 214 ? 131.464 114.629 133.410 1.00 99.06  ? 214 ARG B C   1 
ATOM 5991 O O   . ARG B 1 214 ? 132.692 114.570 133.447 1.00 98.33  ? 214 ARG B O   1 
ATOM 5992 C CB  . ARG B 1 214 ? 130.270 115.461 135.450 1.00 104.48 ? 214 ARG B CB  1 
ATOM 5993 C CG  . ARG B 1 214 ? 131.412 115.171 136.410 1.00 102.81 ? 214 ARG B CG  1 
ATOM 5994 C CD  . ARG B 1 214 ? 131.250 115.940 137.710 1.00 101.62 ? 214 ARG B CD  1 
ATOM 5995 N NE  . ARG B 1 214 ? 129.867 115.939 138.171 1.00 99.06  ? 214 ARG B NE  1 
ATOM 5996 C CZ  . ARG B 1 214 ? 129.351 115.030 138.987 1.00 99.03  ? 214 ARG B CZ  1 
ATOM 5997 N NH1 . ARG B 1 214 ? 130.079 114.030 139.456 1.00 99.53  ? 214 ARG B NH1 1 
ATOM 5998 N NH2 . ARG B 1 214 ? 128.073 115.126 139.340 1.00 98.59  ? 214 ARG B NH2 1 
ATOM 5999 N N   . PHE B 1 215 ? 130.713 113.695 132.833 1.00 92.95  ? 215 PHE B N   1 
ATOM 6000 C CA  . PHE B 1 215 ? 131.289 112.502 132.228 1.00 90.11  ? 215 PHE B CA  1 
ATOM 6001 C C   . PHE B 1 215 ? 131.621 112.681 130.755 1.00 90.12  ? 215 PHE B C   1 
ATOM 6002 O O   . PHE B 1 215 ? 132.047 111.718 130.110 1.00 91.12  ? 215 PHE B O   1 
ATOM 6003 C CB  . PHE B 1 215 ? 130.341 111.311 132.397 1.00 91.18  ? 215 PHE B CB  1 
ATOM 6004 C CG  . PHE B 1 215 ? 130.544 110.552 133.675 1.00 94.43  ? 215 PHE B CG  1 
ATOM 6005 C CD1 . PHE B 1 215 ? 131.356 111.057 134.679 1.00 93.03  ? 215 PHE B CD1 1 
ATOM 6006 C CD2 . PHE B 1 215 ? 129.930 109.328 133.870 1.00 94.20  ? 215 PHE B CD2 1 
ATOM 6007 C CE1 . PHE B 1 215 ? 131.544 110.356 135.856 1.00 92.56  ? 215 PHE B CE1 1 
ATOM 6008 C CE2 . PHE B 1 215 ? 130.113 108.623 135.041 1.00 94.25  ? 215 PHE B CE2 1 
ATOM 6009 C CZ  . PHE B 1 215 ? 130.921 109.136 136.036 1.00 93.66  ? 215 PHE B CZ  1 
ATOM 6010 N N   . ALA B 1 216 ? 131.427 113.875 130.206 1.00 94.73  ? 216 ALA B N   1 
ATOM 6011 C CA  . ALA B 1 216 ? 131.753 114.148 128.815 1.00 97.24  ? 216 ALA B CA  1 
ATOM 6012 C C   . ALA B 1 216 ? 133.159 114.701 128.633 1.00 97.93  ? 216 ALA B C   1 
ATOM 6013 O O   . ALA B 1 216 ? 133.589 114.899 127.492 1.00 96.20  ? 216 ALA B O   1 
ATOM 6014 C CB  . ALA B 1 216 ? 130.737 115.124 128.223 1.00 94.86  ? 216 ALA B CB  1 
ATOM 6015 N N   . ILE B 1 217 ? 133.880 114.954 129.721 1.00 92.64  ? 217 ILE B N   1 
ATOM 6016 C CA  . ILE B 1 217 ? 135.240 115.469 129.653 1.00 90.68  ? 217 ILE B CA  1 
ATOM 6017 C C   . ILE B 1 217 ? 136.267 114.344 129.715 1.00 89.88  ? 217 ILE B C   1 
ATOM 6018 O O   . ILE B 1 217 ? 137.268 114.375 128.998 1.00 89.17  ? 217 ILE B O   1 
ATOM 6019 C CB  . ILE B 1 217 ? 135.485 116.508 130.773 1.00 90.75  ? 217 ILE B CB  1 
ATOM 6020 C CG1 . ILE B 1 217 ? 134.402 117.593 130.770 1.00 90.08  ? 217 ILE B CG1 1 
ATOM 6021 C CG2 . ILE B 1 217 ? 136.858 117.149 130.632 1.00 89.06  ? 217 ILE B CG2 1 
ATOM 6022 C CD1 . ILE B 1 217 ? 133.349 117.433 131.852 1.00 90.77  ? 217 ILE B CD1 1 
ATOM 6023 N N   . ASP B 1 218 ? 136.024 113.337 130.548 1.00 82.62  ? 218 ASP B N   1 
ATOM 6024 C CA  . ASP B 1 218 ? 136.950 112.217 130.720 1.00 82.09  ? 218 ASP B CA  1 
ATOM 6025 C C   . ASP B 1 218 ? 136.302 110.931 130.228 1.00 81.49  ? 218 ASP B C   1 
ATOM 6026 O O   . ASP B 1 218 ? 135.552 110.282 130.979 1.00 81.56  ? 218 ASP B O   1 
ATOM 6027 C CB  . ASP B 1 218 ? 137.373 112.082 132.184 1.00 82.10  ? 218 ASP B CB  1 
ATOM 6028 C CG  . ASP B 1 218 ? 136.232 112.346 133.155 1.00 81.99  ? 218 ASP B CG  1 
ATOM 6029 O OD1 . ASP B 1 218 ? 135.213 112.935 132.739 1.00 81.97  ? 218 ASP B OD1 1 
ATOM 6030 O OD2 . ASP B 1 218 ? 136.357 111.961 134.337 1.00 81.95  ? 218 ASP B OD2 1 
ATOM 6031 N N   . PRO B 1 219 ? 136.553 110.520 128.980 1.00 74.88  ? 219 PRO B N   1 
ATOM 6032 C CA  . PRO B 1 219 ? 135.990 109.250 128.493 1.00 73.42  ? 219 PRO B CA  1 
ATOM 6033 C C   . PRO B 1 219 ? 136.589 108.018 129.152 1.00 71.32  ? 219 PRO B C   1 
ATOM 6034 O O   . PRO B 1 219 ? 136.003 106.935 129.031 1.00 74.94  ? 219 PRO B O   1 
ATOM 6035 C CB  . PRO B 1 219 ? 136.304 109.278 126.989 1.00 74.00  ? 219 PRO B CB  1 
ATOM 6036 C CG  . PRO B 1 219 ? 136.622 110.710 126.678 1.00 75.99  ? 219 PRO B CG  1 
ATOM 6037 C CD  . PRO B 1 219 ? 137.257 111.251 127.916 1.00 75.16  ? 219 PRO B CD  1 
ATOM 6038 N N   . GLU B 1 220 ? 137.732 108.145 129.830 1.00 77.89  ? 220 GLU B N   1 
ATOM 6039 C CA  . GLU B 1 220 ? 138.339 106.996 130.494 1.00 80.34  ? 220 GLU B CA  1 
ATOM 6040 C C   . GLU B 1 220 ? 137.496 106.526 131.672 1.00 82.71  ? 220 GLU B C   1 
ATOM 6041 O O   . GLU B 1 220 ? 137.450 105.328 131.970 1.00 83.98  ? 220 GLU B O   1 
ATOM 6042 C CB  . GLU B 1 220 ? 139.753 107.346 130.955 1.00 79.39  ? 220 GLU B CB  1 
ATOM 6043 C CG  . GLU B 1 220 ? 140.824 107.105 129.906 1.00 81.19  ? 220 GLU B CG  1 
ATOM 6044 C CD  . GLU B 1 220 ? 141.181 108.362 129.138 1.00 82.51  ? 220 GLU B CD  1 
ATOM 6045 O OE1 . GLU B 1 220 ? 140.303 109.235 128.977 1.00 78.95  ? 220 GLU B OE1 1 
ATOM 6046 O OE2 . GLU B 1 220 ? 142.341 108.480 128.696 1.00 86.33  ? 220 GLU B OE2 1 
ATOM 6047 N N   . LEU B 1 221 ? 136.825 107.451 132.352 1.00 80.18  ? 221 LEU B N   1 
ATOM 6048 C CA  . LEU B 1 221 ? 135.960 107.094 133.466 1.00 78.23  ? 221 LEU B CA  1 
ATOM 6049 C C   . LEU B 1 221 ? 134.545 106.748 133.026 1.00 79.82  ? 221 LEU B C   1 
ATOM 6050 O O   . LEU B 1 221 ? 133.704 106.460 133.883 1.00 85.53  ? 221 LEU B O   1 
ATOM 6051 C CB  . LEU B 1 221 ? 135.915 108.232 134.489 1.00 79.35  ? 221 LEU B CB  1 
ATOM 6052 C CG  . LEU B 1 221 ? 135.933 107.842 135.971 1.00 80.11  ? 221 LEU B CG  1 
ATOM 6053 C CD1 . LEU B 1 221 ? 136.878 106.674 136.229 1.00 80.15  ? 221 LEU B CD1 1 
ATOM 6054 C CD2 . LEU B 1 221 ? 136.299 109.037 136.840 1.00 80.13  ? 221 LEU B CD2 1 
ATOM 6055 N N   . ARG B 1 222 ? 134.260 106.779 131.722 1.00 72.78  ? 222 ARG B N   1 
ATOM 6056 C CA  . ARG B 1 222 ? 132.919 106.451 131.250 1.00 75.41  ? 222 ARG B CA  1 
ATOM 6057 C C   . ARG B 1 222 ? 132.628 104.961 131.379 1.00 74.13  ? 222 ARG B C   1 
ATOM 6058 O O   . ARG B 1 222 ? 131.524 104.572 131.781 1.00 73.90  ? 222 ARG B O   1 
ATOM 6059 C CB  . ARG B 1 222 ? 132.748 106.903 129.804 1.00 67.99  ? 222 ARG B CB  1 
ATOM 6060 C CG  . ARG B 1 222 ? 131.439 107.607 129.544 1.00 72.58  ? 222 ARG B CG  1 
ATOM 6061 C CD  . ARG B 1 222 ? 131.524 108.441 128.295 1.00 74.73  ? 222 ARG B CD  1 
ATOM 6062 N NE  . ARG B 1 222 ? 131.487 107.608 127.102 1.00 69.59  ? 222 ARG B NE  1 
ATOM 6063 C CZ  . ARG B 1 222 ? 131.666 108.064 125.872 1.00 73.62  ? 222 ARG B CZ  1 
ATOM 6064 N NH1 . ARG B 1 222 ? 131.909 109.343 125.640 1.00 78.80  ? 222 ARG B NH1 1 
ATOM 6065 N NH2 . ARG B 1 222 ? 131.602 107.217 124.851 1.00 74.69  ? 222 ARG B NH2 1 
ATOM 6066 N N   . GLY B 1 223 ? 133.603 104.116 131.033 1.00 76.22  ? 223 GLY B N   1 
ATOM 6067 C CA  . GLY B 1 223 ? 133.406 102.679 131.142 1.00 79.26  ? 223 GLY B CA  1 
ATOM 6068 C C   . GLY B 1 223 ? 133.230 102.217 132.576 1.00 82.19  ? 223 GLY B C   1 
ATOM 6069 O O   . GLY B 1 223 ? 132.434 101.314 132.851 1.00 84.06  ? 223 GLY B O   1 
ATOM 6070 N N   . ALA B 1 224 ? 133.925 102.871 133.513 1.00 81.41  ? 224 ALA B N   1 
ATOM 6071 C CA  . ALA B 1 224 ? 133.863 102.494 134.922 1.00 82.78  ? 224 ALA B CA  1 
ATOM 6072 C C   . ALA B 1 224 ? 132.484 102.711 135.532 1.00 80.64  ? 224 ALA B C   1 
ATOM 6073 O O   . ALA B 1 224 ? 132.223 102.214 136.632 1.00 81.87  ? 224 ALA B O   1 
ATOM 6074 C CB  . ALA B 1 224 ? 134.908 103.274 135.721 1.00 80.03  ? 224 ALA B CB  1 
ATOM 6075 N N   . GLU B 1 225 ? 131.605 103.450 134.859 1.00 73.31  ? 225 GLU B N   1 
ATOM 6076 C CA  . GLU B 1 225 ? 130.203 103.524 135.244 1.00 77.55  ? 225 GLU B CA  1 
ATOM 6077 C C   . GLU B 1 225 ? 129.286 102.769 134.292 1.00 84.47  ? 225 GLU B C   1 
ATOM 6078 O O   . GLU B 1 225 ? 128.277 102.207 134.732 1.00 87.06  ? 225 GLU B O   1 
ATOM 6079 C CB  . GLU B 1 225 ? 129.755 104.984 135.340 1.00 80.81  ? 225 GLU B CB  1 
ATOM 6080 C CG  . GLU B 1 225 ? 129.716 105.524 136.763 1.00 84.44  ? 225 GLU B CG  1 
ATOM 6081 C CD  . GLU B 1 225 ? 129.136 104.530 137.752 1.00 84.02  ? 225 GLU B CD  1 
ATOM 6082 O OE1 . GLU B 1 225 ? 127.899 104.358 137.765 1.00 84.85  ? 225 GLU B OE1 1 
ATOM 6083 O OE2 . GLU B 1 225 ? 129.914 103.930 138.523 1.00 81.19  ? 225 GLU B OE2 1 
ATOM 6084 N N   . PHE B 1 226 ? 129.621 102.727 132.997 1.00 78.31  ? 226 PHE B N   1 
ATOM 6085 C CA  . PHE B 1 226 ? 128.762 102.059 132.021 1.00 79.47  ? 226 PHE B CA  1 
ATOM 6086 C C   . PHE B 1 226 ? 128.707 100.551 132.249 1.00 74.71  ? 226 PHE B C   1 
ATOM 6087 O O   . PHE B 1 226 ? 127.635 99.945  132.133 1.00 79.83  ? 226 PHE B O   1 
ATOM 6088 C CB  . PHE B 1 226 ? 129.251 102.381 130.605 1.00 72.96  ? 226 PHE B CB  1 
ATOM 6089 C CG  . PHE B 1 226 ? 128.240 102.106 129.523 1.00 75.29  ? 226 PHE B CG  1 
ATOM 6090 C CD1 . PHE B 1 226 ? 128.010 100.822 129.065 1.00 75.56  ? 226 PHE B CD1 1 
ATOM 6091 C CD2 . PHE B 1 226 ? 127.515 103.143 128.965 1.00 77.29  ? 226 PHE B CD2 1 
ATOM 6092 C CE1 . PHE B 1 226 ? 127.086 100.576 128.073 1.00 75.85  ? 226 PHE B CE1 1 
ATOM 6093 C CE2 . PHE B 1 226 ? 126.584 102.899 127.976 1.00 75.93  ? 226 PHE B CE2 1 
ATOM 6094 C CZ  . PHE B 1 226 ? 126.372 101.617 127.528 1.00 75.49  ? 226 PHE B CZ  1 
ATOM 6095 N N   . GLU B 1 227 ? 129.839 99.927  132.572 1.00 69.98  ? 227 GLU B N   1 
ATOM 6096 C CA  . GLU B 1 227 ? 129.843 98.478  132.732 1.00 73.41  ? 227 GLU B CA  1 
ATOM 6097 C C   . GLU B 1 227 ? 129.269 98.053  134.077 1.00 78.17  ? 227 GLU B C   1 
ATOM 6098 O O   . GLU B 1 227 ? 128.910 96.884  134.251 1.00 78.41  ? 227 GLU B O   1 
ATOM 6099 C CB  . GLU B 1 227 ? 131.261 97.965  132.527 1.00 80.83  ? 227 GLU B CB  1 
ATOM 6100 C CG  . GLU B 1 227 ? 131.847 98.587  131.283 1.00 82.85  ? 227 GLU B CG  1 
ATOM 6101 C CD  . GLU B 1 227 ? 133.343 98.726  131.325 1.00 81.29  ? 227 GLU B CD  1 
ATOM 6102 O OE1 . GLU B 1 227 ? 133.869 99.423  130.435 1.00 82.49  ? 227 GLU B OE1 1 
ATOM 6103 O OE2 . GLU B 1 227 ? 133.984 98.148  132.227 1.00 78.57  ? 227 GLU B OE2 1 
ATOM 6104 N N   . ARG B 1 228 ? 129.176 98.978  135.035 1.00 80.48  ? 228 ARG B N   1 
ATOM 6105 C CA  . ARG B 1 228 ? 128.384 98.722  136.233 1.00 80.11  ? 228 ARG B CA  1 
ATOM 6106 C C   . ARG B 1 228 ? 126.899 98.931  135.974 1.00 78.95  ? 228 ARG B C   1 
ATOM 6107 O O   . ARG B 1 228 ? 126.064 98.241  136.572 1.00 79.02  ? 228 ARG B O   1 
ATOM 6108 C CB  . ARG B 1 228 ? 128.852 99.617  137.380 1.00 80.13  ? 228 ARG B CB  1 
ATOM 6109 C CG  . ARG B 1 228 ? 130.359 99.665  137.547 1.00 80.88  ? 228 ARG B CG  1 
ATOM 6110 C CD  . ARG B 1 228 ? 130.932 98.286  137.820 1.00 79.21  ? 228 ARG B CD  1 
ATOM 6111 N NE  . ARG B 1 228 ? 132.087 98.001  136.977 1.00 77.89  ? 228 ARG B NE  1 
ATOM 6112 C CZ  . ARG B 1 228 ? 133.340 98.287  137.301 1.00 80.56  ? 228 ARG B CZ  1 
ATOM 6113 N NH1 . ARG B 1 228 ? 133.640 98.882  138.443 1.00 79.56  ? 228 ARG B NH1 1 
ATOM 6114 N NH2 . ARG B 1 228 ? 134.317 97.969  136.456 1.00 82.49  ? 228 ARG B NH2 1 
ATOM 6115 N N   . ILE B 1 229 ? 126.562 99.876  135.092 1.00 68.02  ? 229 ILE B N   1 
ATOM 6116 C CA  . ILE B 1 229 ? 125.175 100.080 134.678 1.00 71.95  ? 229 ILE B CA  1 
ATOM 6117 C C   . ILE B 1 229 ? 124.640 98.847  133.964 1.00 74.15  ? 229 ILE B C   1 
ATOM 6118 O O   . ILE B 1 229 ? 123.485 98.447  134.167 1.00 71.99  ? 229 ILE B O   1 
ATOM 6119 C CB  . ILE B 1 229 ? 125.081 101.343 133.802 1.00 68.70  ? 229 ILE B CB  1 
ATOM 6120 C CG1 . ILE B 1 229 ? 125.015 102.575 134.692 1.00 71.40  ? 229 ILE B CG1 1 
ATOM 6121 C CG2 . ILE B 1 229 ? 123.904 101.294 132.826 1.00 74.05  ? 229 ILE B CG2 1 
ATOM 6122 C CD1 . ILE B 1 229 ? 125.010 103.823 133.924 1.00 73.90  ? 229 ILE B CD1 1 
ATOM 6123 N N   . THR B 1 230 ? 125.479 98.227  133.128 1.00 79.47  ? 230 THR B N   1 
ATOM 6124 C CA  . THR B 1 230 ? 125.085 97.038  132.373 1.00 74.49  ? 230 THR B CA  1 
ATOM 6125 C C   . THR B 1 230 ? 124.597 95.923  133.294 1.00 75.82  ? 230 THR B C   1 
ATOM 6126 O O   . THR B 1 230 ? 123.513 95.366  133.092 1.00 70.92  ? 230 THR B O   1 
ATOM 6127 C CB  . THR B 1 230 ? 126.266 96.559  131.521 1.00 80.47  ? 230 THR B CB  1 
ATOM 6128 O OG1 . THR B 1 230 ? 126.347 97.345  130.326 1.00 85.22  ? 230 THR B OG1 1 
ATOM 6129 C CG2 . THR B 1 230 ? 126.138 95.079  131.154 1.00 75.74  ? 230 THR B CG2 1 
ATOM 6130 N N   . GLN B 1 231 ? 125.355 95.624  134.343 1.00 86.09  ? 231 GLN B N   1 
ATOM 6131 C CA  . GLN B 1 231 ? 125.012 94.529  135.237 1.00 84.67  ? 231 GLN B CA  1 
ATOM 6132 C C   . GLN B 1 231 ? 124.272 94.983  136.489 1.00 82.12  ? 231 GLN B C   1 
ATOM 6133 O O   . GLN B 1 231 ? 124.019 94.156  137.370 1.00 82.51  ? 231 GLN B O   1 
ATOM 6134 C CB  . GLN B 1 231 ? 126.276 93.760  135.629 1.00 85.69  ? 231 GLN B CB  1 
ATOM 6135 C CG  . GLN B 1 231 ? 127.136 93.350  134.442 1.00 83.28  ? 231 GLN B CG  1 
ATOM 6136 C CD  . GLN B 1 231 ? 128.357 92.555  134.855 1.00 85.36  ? 231 GLN B CD  1 
ATOM 6137 O OE1 . GLN B 1 231 ? 128.313 91.328  134.942 0.83 84.57  ? 231 GLN B OE1 1 
ATOM 6138 N NE2 . GLN B 1 231 ? 129.457 93.253  135.116 1.00 83.39  ? 231 GLN B NE2 1 
ATOM 6139 N N   . ASN B 1 232 ? 123.919 96.261  136.596 1.00 68.69  ? 232 ASN B N   1 
ATOM 6140 C CA  . ASN B 1 232 ? 123.192 96.771  137.754 1.00 75.82  ? 232 ASN B CA  1 
ATOM 6141 C C   . ASN B 1 232 ? 122.013 97.632  137.316 1.00 77.06  ? 232 ASN B C   1 
ATOM 6142 O O   . ASN B 1 232 ? 121.794 98.736  137.818 1.00 75.62  ? 232 ASN B O   1 
ATOM 6143 C CB  . ASN B 1 232 ? 124.123 97.554  138.676 1.00 75.08  ? 232 ASN B CB  1 
ATOM 6144 C CG  . ASN B 1 232 ? 125.207 96.684  139.282 1.00 75.47  ? 232 ASN B CG  1 
ATOM 6145 O OD1 . ASN B 1 232 ? 124.936 95.589  139.774 0.32 75.69  ? 232 ASN B OD1 1 
ATOM 6146 N ND2 . ASN B 1 232 ? 126.443 97.168  139.248 1.00 75.68  ? 232 ASN B ND2 1 
ATOM 6147 N N   . LEU B 1 233 ? 121.229 97.128  136.366 1.00 79.79  ? 233 LEU B N   1 
ATOM 6148 C CA  . LEU B 1 233 ? 120.020 97.806  135.923 1.00 77.50  ? 233 LEU B CA  1 
ATOM 6149 C C   . LEU B 1 233 ? 118.836 96.861  136.068 1.00 77.98  ? 233 LEU B C   1 
ATOM 6150 O O   . LEU B 1 233 ? 118.993 95.641  136.148 1.00 76.29  ? 233 LEU B O   1 
ATOM 6151 C CB  . LEU B 1 233 ? 120.144 98.312  134.470 1.00 73.14  ? 233 LEU B CB  1 
ATOM 6152 C CG  . LEU B 1 233 ? 120.038 97.400  133.241 1.00 77.95  ? 233 LEU B CG  1 
ATOM 6153 C CD1 . LEU B 1 233 ? 118.624 97.336  132.677 1.00 70.02  ? 233 LEU B CD1 1 
ATOM 6154 C CD2 . LEU B 1 233 ? 120.995 97.866  132.166 1.00 81.70  ? 233 LEU B CD2 1 
ATOM 6155 N N   . ASP B 1 234 ? 117.643 97.445  136.110 1.00 79.24  ? 234 ASP B N   1 
ATOM 6156 C CA  . ASP B 1 234 ? 116.400 96.700  136.232 1.00 77.88  ? 234 ASP B CA  1 
ATOM 6157 C C   . ASP B 1 234 ? 115.565 96.892  134.974 1.00 76.76  ? 234 ASP B C   1 
ATOM 6158 O O   . ASP B 1 234 ? 115.791 97.817  134.191 1.00 77.59  ? 234 ASP B O   1 
ATOM 6159 C CB  . ASP B 1 234 ? 115.606 97.147  137.466 1.00 77.97  ? 234 ASP B CB  1 
ATOM 6160 C CG  . ASP B 1 234 ? 114.774 96.031  138.057 1.00 79.08  ? 234 ASP B CG  1 
ATOM 6161 O OD1 . ASP B 1 234 ? 115.362 95.075  138.603 1.00 80.13  ? 234 ASP B OD1 1 
ATOM 6162 O OD2 . ASP B 1 234 ? 113.531 96.111  137.978 1.00 79.44  ? 234 ASP B OD2 1 
ATOM 6163 N N   . VAL B 1 235 ? 114.596 95.994  134.778 1.00 78.40  ? 235 VAL B N   1 
ATOM 6164 C CA  . VAL B 1 235 ? 113.697 96.120  133.634 1.00 78.95  ? 235 VAL B CA  1 
ATOM 6165 C C   . VAL B 1 235 ? 112.822 97.364  133.776 1.00 75.91  ? 235 VAL B C   1 
ATOM 6166 O O   . VAL B 1 235 ? 112.527 98.043  132.782 1.00 74.26  ? 235 VAL B O   1 
ATOM 6167 C CB  . VAL B 1 235 ? 112.875 94.824  133.463 1.00 77.72  ? 235 VAL B CB  1 
ATOM 6168 C CG1 . VAL B 1 235 ? 112.178 94.432  134.763 1.00 77.77  ? 235 VAL B CG1 1 
ATOM 6169 C CG2 . VAL B 1 235 ? 111.879 94.942  132.312 1.00 74.18  ? 235 VAL B CG2 1 
ATOM 6170 N N   . HIS B 1 236 ? 112.431 97.709  135.008 1.00 72.54  ? 236 HIS B N   1 
ATOM 6171 C CA  . HIS B 1 236 ? 111.679 98.936  135.248 1.00 73.10  ? 236 HIS B CA  1 
ATOM 6172 C C   . HIS B 1 236 ? 112.504 100.173 134.917 1.00 76.87  ? 236 HIS B C   1 
ATOM 6173 O O   . HIS B 1 236 ? 111.948 101.194 134.497 1.00 80.34  ? 236 HIS B O   1 
ATOM 6174 C CB  . HIS B 1 236 ? 111.216 98.984  136.704 1.00 74.73  ? 236 HIS B CB  1 
ATOM 6175 C CG  . HIS B 1 236 ? 109.839 98.439  136.917 1.00 77.09  ? 236 HIS B CG  1 
ATOM 6176 N ND1 . HIS B 1 236 ? 108.783 98.738  136.084 1.00 84.26  ? 236 HIS B ND1 1 
ATOM 6177 C CD2 . HIS B 1 236 ? 109.347 97.605  137.863 1.00 82.83  ? 236 HIS B CD2 1 
ATOM 6178 C CE1 . HIS B 1 236 ? 107.698 98.116  136.511 1.00 81.34  ? 236 HIS B CE1 1 
ATOM 6179 N NE2 . HIS B 1 236 ? 108.013 97.422  137.589 1.00 84.03  ? 236 HIS B NE2 1 
ATOM 6180 N N   . PHE B 1 237 ? 113.824 100.104 135.119 1.00 72.05  ? 237 PHE B N   1 
ATOM 6181 C CA  . PHE B 1 237 ? 114.714 101.187 134.714 1.00 68.57  ? 237 PHE B CA  1 
ATOM 6182 C C   . PHE B 1 237 ? 114.685 101.354 133.197 1.00 66.71  ? 237 PHE B C   1 
ATOM 6183 O O   . PHE B 1 237 ? 114.540 102.476 132.701 1.00 70.98  ? 237 PHE B O   1 
ATOM 6184 C CB  . PHE B 1 237 ? 116.131 100.873 135.226 1.00 72.33  ? 237 PHE B CB  1 
ATOM 6185 C CG  . PHE B 1 237 ? 117.232 101.822 134.767 1.00 71.50  ? 237 PHE B CG  1 
ATOM 6186 C CD1 . PHE B 1 237 ? 118.579 101.480 134.779 1.00 73.50  ? 237 PHE B CD1 1 
ATOM 6187 C CD2 . PHE B 1 237 ? 116.886 103.092 134.337 1.00 71.41  ? 237 PHE B CD2 1 
ATOM 6188 C CE1 . PHE B 1 237 ? 119.540 102.378 134.353 1.00 72.30  ? 237 PHE B CE1 1 
ATOM 6189 C CE2 . PHE B 1 237 ? 117.840 103.995 133.918 1.00 69.63  ? 237 PHE B CE2 1 
ATOM 6190 C CZ  . PHE B 1 237 ? 119.168 103.640 133.925 1.00 70.75  ? 237 PHE B CZ  1 
ATOM 6191 N N   . TRP B 1 238 ? 114.765 100.253 132.449 1.00 72.71  ? 238 TRP B N   1 
ATOM 6192 C CA  . TRP B 1 238 ? 114.752 100.341 130.995 1.00 69.60  ? 238 TRP B CA  1 
ATOM 6193 C C   . TRP B 1 238 ? 113.361 100.588 130.433 1.00 68.51  ? 238 TRP B C   1 
ATOM 6194 O O   . TRP B 1 238 ? 113.233 100.845 129.231 1.00 64.45  ? 238 TRP B O   1 
ATOM 6195 C CB  . TRP B 1 238 ? 115.341 99.072  130.371 1.00 70.76  ? 238 TRP B CB  1 
ATOM 6196 C CG  . TRP B 1 238 ? 116.121 99.358  129.125 1.00 68.13  ? 238 TRP B CG  1 
ATOM 6197 C CD1 . TRP B 1 238 ? 115.637 99.422  127.853 1.00 67.34  ? 238 TRP B CD1 1 
ATOM 6198 C CD2 . TRP B 1 238 ? 117.524 99.635  129.036 1.00 68.18  ? 238 TRP B CD2 1 
ATOM 6199 N NE1 . TRP B 1 238 ? 116.652 99.719  126.976 1.00 67.97  ? 238 TRP B NE1 1 
ATOM 6200 C CE2 . TRP B 1 238 ? 117.820 99.854  127.677 1.00 71.27  ? 238 TRP B CE2 1 
ATOM 6201 C CE3 . TRP B 1 238 ? 118.558 99.717  129.972 1.00 68.66  ? 238 TRP B CE3 1 
ATOM 6202 C CZ2 . TRP B 1 238 ? 119.105 100.149 127.231 1.00 69.39  ? 238 TRP B CZ2 1 
ATOM 6203 C CZ3 . TRP B 1 238 ? 119.832 100.011 129.527 1.00 63.97  ? 238 TRP B CZ3 1 
ATOM 6204 C CH2 . TRP B 1 238 ? 120.095 100.223 128.171 1.00 65.78  ? 238 TRP B CH2 1 
ATOM 6205 N N   . LYS B 1 239 ? 112.322 100.530 131.270 1.00 69.21  ? 239 LYS B N   1 
ATOM 6206 C CA  . LYS B 1 239 ? 110.977 100.894 130.842 1.00 66.50  ? 239 LYS B CA  1 
ATOM 6207 C C   . LYS B 1 239 ? 110.822 102.385 130.569 1.00 72.39  ? 239 LYS B C   1 
ATOM 6208 O O   . LYS B 1 239 ? 109.785 102.786 130.034 1.00 68.81  ? 239 LYS B O   1 
ATOM 6209 C CB  . LYS B 1 239 ? 109.947 100.472 131.893 1.00 66.66  ? 239 LYS B CB  1 
ATOM 6210 C CG  . LYS B 1 239 ? 109.568 99.008  131.837 1.00 61.83  ? 239 LYS B CG  1 
ATOM 6211 C CD  . LYS B 1 239 ? 108.404 98.682  132.755 1.00 67.94  ? 239 LYS B CD  1 
ATOM 6212 C CE  . LYS B 1 239 ? 107.153 99.438  132.354 1.00 66.37  ? 239 LYS B CE  1 
ATOM 6213 N NZ  . LYS B 1 239 ? 106.346 98.664  131.372 1.00 65.25  ? 239 LYS B NZ  1 
ATOM 6214 N N   . ALA B 1 240 ? 111.800 103.211 130.941 1.00 66.24  ? 240 ALA B N   1 
ATOM 6215 C CA  . ALA B 1 240 ? 111.744 104.644 130.688 1.00 58.85  ? 240 ALA B CA  1 
ATOM 6216 C C   . ALA B 1 240 ? 112.531 105.073 129.457 1.00 56.58  ? 240 ALA B C   1 
ATOM 6217 O O   . ALA B 1 240 ? 112.188 106.088 128.843 1.00 60.32  ? 240 ALA B O   1 
ATOM 6218 C CB  . ALA B 1 240 ? 112.256 105.419 131.906 1.00 54.04  ? 240 ALA B CB  1 
ATOM 6219 N N   . PHE B 1 241 ? 113.560 104.317 129.068 1.00 65.23  ? 241 PHE B N   1 
ATOM 6220 C CA  . PHE B 1 241 ? 114.458 104.765 128.007 1.00 66.47  ? 241 PHE B CA  1 
ATOM 6221 C C   . PHE B 1 241 ? 113.780 104.748 126.644 1.00 60.93  ? 241 PHE B C   1 
ATOM 6222 O O   . PHE B 1 241 ? 113.946 105.677 125.847 1.00 64.75  ? 241 PHE B O   1 
ATOM 6223 C CB  . PHE B 1 241 ? 115.710 103.893 127.972 1.00 67.27  ? 241 PHE B CB  1 
ATOM 6224 C CG  . PHE B 1 241 ? 116.821 104.399 128.829 1.00 63.08  ? 241 PHE B CG  1 
ATOM 6225 C CD1 . PHE B 1 241 ? 117.523 105.533 128.467 1.00 61.57  ? 241 PHE B CD1 1 
ATOM 6226 C CD2 . PHE B 1 241 ? 117.179 103.729 129.985 1.00 62.87  ? 241 PHE B CD2 1 
ATOM 6227 C CE1 . PHE B 1 241 ? 118.550 106.000 129.251 1.00 64.57  ? 241 PHE B CE1 1 
ATOM 6228 C CE2 . PHE B 1 241 ? 118.205 104.189 130.770 1.00 65.15  ? 241 PHE B CE2 1 
ATOM 6229 C CZ  . PHE B 1 241 ? 118.893 105.325 130.407 1.00 66.00  ? 241 PHE B CZ  1 
ATOM 6230 N N   . TRP B 1 242 ? 113.033 103.688 126.345 1.00 49.63  ? 242 TRP B N   1 
ATOM 6231 C CA  . TRP B 1 242 ? 112.456 103.572 125.012 1.00 48.27  ? 242 TRP B CA  1 
ATOM 6232 C C   . TRP B 1 242 ? 111.254 104.490 124.833 1.00 52.37  ? 242 TRP B C   1 
ATOM 6233 O O   . TRP B 1 242 ? 110.944 104.885 123.704 1.00 50.85  ? 242 TRP B O   1 
ATOM 6234 C CB  . TRP B 1 242 ? 112.077 102.121 124.727 1.00 52.69  ? 242 TRP B CB  1 
ATOM 6235 C CG  . TRP B 1 242 ? 113.255 101.247 124.417 1.00 53.95  ? 242 TRP B CG  1 
ATOM 6236 C CD1 . TRP B 1 242 ? 113.746 100.233 125.183 1.00 51.58  ? 242 TRP B CD1 1 
ATOM 6237 C CD2 . TRP B 1 242 ? 114.091 101.312 123.255 1.00 55.16  ? 242 TRP B CD2 1 
ATOM 6238 N NE1 . TRP B 1 242 ? 114.831 99.659  124.569 1.00 49.05  ? 242 TRP B NE1 1 
ATOM 6239 C CE2 . TRP B 1 242 ? 115.065 100.305 123.385 1.00 54.78  ? 242 TRP B CE2 1 
ATOM 6240 C CE3 . TRP B 1 242 ? 114.109 102.125 122.117 1.00 55.96  ? 242 TRP B CE3 1 
ATOM 6241 C CZ2 . TRP B 1 242 ? 116.047 100.088 122.422 1.00 60.99  ? 242 TRP B CZ2 1 
ATOM 6242 C CZ3 . TRP B 1 242 ? 115.085 101.908 121.161 1.00 52.18  ? 242 TRP B CZ3 1 
ATOM 6243 C CH2 . TRP B 1 242 ? 116.040 100.898 121.320 1.00 58.17  ? 242 TRP B CH2 1 
ATOM 6244 N N   . ASN B 1 243 ? 110.571 104.846 125.922 1.00 59.25  ? 243 ASN B N   1 
ATOM 6245 C CA  . ASN B 1 243 ? 109.457 105.782 125.858 1.00 62.56  ? 243 ASN B CA  1 
ATOM 6246 C C   . ASN B 1 243 ? 109.823 107.158 126.418 1.00 65.95  ? 243 ASN B C   1 
ATOM 6247 O O   . ASN B 1 243 ? 108.936 107.948 126.756 1.00 65.06  ? 243 ASN B O   1 
ATOM 6248 C CB  . ASN B 1 243 ? 108.224 105.189 126.552 1.00 61.68  ? 243 ASN B CB  1 
ATOM 6249 C CG  . ASN B 1 243 ? 108.253 105.343 128.057 1.00 65.66  ? 243 ASN B CG  1 
ATOM 6250 O OD1 . ASN B 1 243 ? 109.294 105.209 128.685 1.00 67.33  ? 243 ASN B OD1 1 
ATOM 6251 N ND2 . ASN B 1 243 ? 107.096 105.623 128.642 1.00 63.51  ? 243 ASN B ND2 1 
ATOM 6252 N N   . ILE B 1 244 ? 111.119 107.465 126.520 1.00 59.90  ? 244 ILE B N   1 
ATOM 6253 C CA  . ILE B 1 244 ? 111.530 108.854 126.698 1.00 54.40  ? 244 ILE B CA  1 
ATOM 6254 C C   . ILE B 1 244 ? 111.142 109.713 125.498 1.00 48.64  ? 244 ILE B C   1 
ATOM 6255 O O   . ILE B 1 244 ? 111.068 110.939 125.618 1.00 58.77  ? 244 ILE B O   1 
ATOM 6256 C CB  . ILE B 1 244 ? 113.047 108.936 126.992 1.00 57.10  ? 244 ILE B CB  1 
ATOM 6257 C CG1 . ILE B 1 244 ? 113.332 110.036 128.013 1.00 59.56  ? 244 ILE B CG1 1 
ATOM 6258 C CG2 . ILE B 1 244 ? 113.861 109.169 125.722 1.00 53.85  ? 244 ILE B CG2 1 
ATOM 6259 C CD1 . ILE B 1 244 ? 112.925 109.679 129.422 1.00 59.61  ? 244 ILE B CD1 1 
ATOM 6260 N N   . THR B 1 245 ? 110.880 109.101 124.343 1.00 45.32  ? 245 THR B N   1 
ATOM 6261 C CA  . THR B 1 245 ? 110.306 109.793 123.199 1.00 53.97  ? 245 THR B CA  1 
ATOM 6262 C C   . THR B 1 245 ? 108.781 109.754 123.192 1.00 67.15  ? 245 THR B C   1 
ATOM 6263 O O   . THR B 1 245 ? 108.169 110.216 122.223 1.00 67.05  ? 245 THR B O   1 
ATOM 6264 C CB  . THR B 1 245 ? 110.852 109.202 121.893 1.00 50.68  ? 245 THR B CB  1 
ATOM 6265 O OG1 . THR B 1 245 ? 110.171 109.786 120.775 1.00 54.18  ? 245 THR B OG1 1 
ATOM 6266 C CG2 . THR B 1 245 ? 110.675 107.697 121.871 1.00 58.30  ? 245 THR B CG2 1 
ATOM 6267 N N   . GLU B 1 246 ? 108.157 109.207 124.238 1.00 62.22  ? 246 GLU B N   1 
ATOM 6268 C CA  . GLU B 1 246 ? 106.706 109.246 124.387 1.00 62.41  ? 246 GLU B CA  1 
ATOM 6269 C C   . GLU B 1 246 ? 106.217 110.507 125.082 1.00 59.61  ? 246 GLU B C   1 
ATOM 6270 O O   . GLU B 1 246 ? 105.073 110.921 124.857 1.00 64.18  ? 246 GLU B O   1 
ATOM 6271 C CB  . GLU B 1 246 ? 106.212 108.026 125.171 1.00 62.43  ? 246 GLU B CB  1 
ATOM 6272 C CG  . GLU B 1 246 ? 104.748 107.701 124.989 1.00 63.98  ? 246 GLU B CG  1 
ATOM 6273 C CD  . GLU B 1 246 ? 104.088 107.274 126.287 1.00 67.78  ? 246 GLU B CD  1 
ATOM 6274 O OE1 . GLU B 1 246 ? 102.856 107.070 126.292 1.00 67.50  ? 246 GLU B OE1 1 
ATOM 6275 O OE2 . GLU B 1 246 ? 104.801 107.143 127.304 1.00 68.17  ? 246 GLU B OE2 1 
ATOM 6276 N N   . MET B 1 247 ? 107.047 111.116 125.929 1.00 62.23  ? 247 MET B N   1 
ATOM 6277 C CA  . MET B 1 247 ? 106.656 112.343 126.611 1.00 66.77  ? 247 MET B CA  1 
ATOM 6278 C C   . MET B 1 247 ? 106.471 113.472 125.604 1.00 67.25  ? 247 MET B C   1 
ATOM 6279 O O   . MET B 1 247 ? 107.074 113.477 124.526 1.00 63.17  ? 247 MET B O   1 
ATOM 6280 C CB  . MET B 1 247 ? 107.693 112.717 127.673 1.00 67.77  ? 247 MET B CB  1 
ATOM 6281 C CG  . MET B 1 247 ? 109.070 113.054 127.132 1.00 66.79  ? 247 MET B CG  1 
ATOM 6282 S SD  . MET B 1 247 ? 110.313 113.070 128.439 1.00 71.31  ? 247 MET B SD  1 
ATOM 6283 C CE  . MET B 1 247 ? 111.559 114.141 127.728 1.00 63.99  ? 247 MET B CE  1 
ATOM 6284 N N   . GLU B 1 248 ? 105.601 114.425 125.959 1.00 73.33  ? 248 GLU B N   1 
ATOM 6285 C CA  . GLU B 1 248 ? 105.084 115.363 124.967 1.00 73.63  ? 248 GLU B CA  1 
ATOM 6286 C C   . GLU B 1 248 ? 106.153 116.330 124.470 1.00 78.83  ? 248 GLU B C   1 
ATOM 6287 O O   . GLU B 1 248 ? 106.102 116.752 123.308 1.00 80.30  ? 248 GLU B O   1 
ATOM 6288 C CB  . GLU B 1 248 ? 103.874 116.120 125.529 1.00 74.01  ? 248 GLU B CB  1 
ATOM 6289 C CG  . GLU B 1 248 ? 104.183 117.225 126.527 1.00 75.82  ? 248 GLU B CG  1 
ATOM 6290 C CD  . GLU B 1 248 ? 103.139 118.326 126.510 1.00 73.38  ? 248 GLU B CD  1 
ATOM 6291 O OE1 . GLU B 1 248 ? 101.939 118.013 126.652 1.00 74.50  ? 248 GLU B OE1 1 
ATOM 6292 O OE2 . GLU B 1 248 ? 103.519 119.504 126.341 1.00 74.35  ? 248 GLU B OE2 1 
ATOM 6293 N N   . VAL B 1 249 ? 107.145 116.656 125.304 1.00 72.89  ? 249 VAL B N   1 
ATOM 6294 C CA  . VAL B 1 249 ? 108.173 117.602 124.882 1.00 69.86  ? 249 VAL B CA  1 
ATOM 6295 C C   . VAL B 1 249 ? 109.081 116.983 123.819 1.00 74.96  ? 249 VAL B C   1 
ATOM 6296 O O   . VAL B 1 249 ? 109.334 117.596 122.776 1.00 77.13  ? 249 VAL B O   1 
ATOM 6297 C CB  . VAL B 1 249 ? 108.954 118.131 126.102 1.00 68.37  ? 249 VAL B CB  1 
ATOM 6298 C CG1 . VAL B 1 249 ? 108.065 119.037 126.916 1.00 64.93  ? 249 VAL B CG1 1 
ATOM 6299 C CG2 . VAL B 1 249 ? 109.425 117.002 126.999 1.00 71.21  ? 249 VAL B CG2 1 
ATOM 6300 N N   . LEU B 1 250 ? 109.526 115.740 124.023 1.00 71.31  ? 250 LEU B N   1 
ATOM 6301 C CA  . LEU B 1 250 ? 110.411 115.112 123.049 1.00 70.34  ? 250 LEU B CA  1 
ATOM 6302 C C   . LEU B 1 250 ? 109.658 114.632 121.814 1.00 67.50  ? 250 LEU B C   1 
ATOM 6303 O O   . LEU B 1 250 ? 110.202 114.689 120.706 1.00 67.10  ? 250 LEU B O   1 
ATOM 6304 C CB  . LEU B 1 250 ? 111.174 113.953 123.693 1.00 68.82  ? 250 LEU B CB  1 
ATOM 6305 C CG  . LEU B 1 250 ? 112.386 113.427 122.916 1.00 68.81  ? 250 LEU B CG  1 
ATOM 6306 C CD1 . LEU B 1 250 ? 113.189 114.562 122.298 1.00 66.64  ? 250 LEU B CD1 1 
ATOM 6307 C CD2 . LEU B 1 250 ? 113.276 112.587 123.814 1.00 70.80  ? 250 LEU B CD2 1 
ATOM 6308 N N   . SER B 1 251 ? 108.416 114.168 121.975 1.00 59.00  ? 251 SER B N   1 
ATOM 6309 C CA  . SER B 1 251 ? 107.616 113.801 120.810 1.00 63.90  ? 251 SER B CA  1 
ATOM 6310 C C   . SER B 1 251 ? 107.306 115.022 119.952 1.00 65.83  ? 251 SER B C   1 
ATOM 6311 O O   . SER B 1 251 ? 107.362 114.953 118.717 1.00 65.17  ? 251 SER B O   1 
ATOM 6312 C CB  . SER B 1 251 ? 106.328 113.109 121.250 1.00 69.09  ? 251 SER B CB  1 
ATOM 6313 O OG  . SER B 1 251 ? 105.537 113.972 122.042 1.00 77.12  ? 251 SER B OG  1 
ATOM 6314 N N   . SER B 1 252 ? 106.993 116.154 120.590 1.00 69.49  ? 252 SER B N   1 
ATOM 6315 C CA  . SER B 1 252 ? 106.806 117.395 119.846 1.00 68.80  ? 252 SER B CA  1 
ATOM 6316 C C   . SER B 1 252 ? 108.106 117.852 119.195 1.00 73.33  ? 252 SER B C   1 
ATOM 6317 O O   . SER B 1 252 ? 108.095 118.335 118.058 1.00 70.40  ? 252 SER B O   1 
ATOM 6318 C CB  . SER B 1 252 ? 106.252 118.480 120.767 1.00 65.60  ? 252 SER B CB  1 
ATOM 6319 O OG  . SER B 1 252 ? 107.020 118.577 121.950 1.00 70.93  ? 252 SER B OG  1 
ATOM 6320 N N   . LEU B 1 253 ? 109.238 117.694 119.889 1.00 80.98  ? 253 LEU B N   1 
ATOM 6321 C CA  . LEU B 1 253 ? 110.540 118.038 119.328 1.00 74.76  ? 253 LEU B CA  1 
ATOM 6322 C C   . LEU B 1 253 ? 110.988 117.096 118.219 1.00 82.77  ? 253 LEU B C   1 
ATOM 6323 O O   . LEU B 1 253 ? 111.933 117.429 117.496 1.00 86.29  ? 253 LEU B O   1 
ATOM 6324 C CB  . LEU B 1 253 ? 111.598 118.045 120.429 1.00 75.01  ? 253 LEU B CB  1 
ATOM 6325 C CG  . LEU B 1 253 ? 111.995 119.412 120.976 1.00 76.77  ? 253 LEU B CG  1 
ATOM 6326 C CD1 . LEU B 1 253 ? 112.837 119.266 122.235 1.00 79.71  ? 253 LEU B CD1 1 
ATOM 6327 C CD2 . LEU B 1 253 ? 112.732 120.211 119.914 1.00 78.52  ? 253 LEU B CD2 1 
ATOM 6328 N N   . ALA B 1 254 ? 110.373 115.921 118.096 1.00 77.26  ? 254 ALA B N   1 
ATOM 6329 C CA  . ALA B 1 254 ? 110.693 115.005 117.011 1.00 73.46  ? 254 ALA B CA  1 
ATOM 6330 C C   . ALA B 1 254 ? 109.667 115.013 115.888 1.00 69.85  ? 254 ALA B C   1 
ATOM 6331 O O   . ALA B 1 254 ? 109.941 114.457 114.819 1.00 70.91  ? 254 ALA B O   1 
ATOM 6332 C CB  . ALA B 1 254 ? 110.830 113.575 117.548 1.00 73.15  ? 254 ALA B CB  1 
ATOM 6333 N N   . ASN B 1 255 ? 108.501 115.623 116.099 1.00 70.98  ? 255 ASN B N   1 
ATOM 6334 C CA  . ASN B 1 255 ? 107.414 115.488 115.138 1.00 75.76  ? 255 ASN B CA  1 
ATOM 6335 C C   . ASN B 1 255 ? 107.520 116.404 113.919 1.00 77.57  ? 255 ASN B C   1 
ATOM 6336 O O   . ASN B 1 255 ? 106.774 116.190 112.957 1.00 80.42  ? 255 ASN B O   1 
ATOM 6337 C CB  . ASN B 1 255 ? 106.075 115.729 115.837 1.00 73.43  ? 255 ASN B CB  1 
ATOM 6338 C CG  . ASN B 1 255 ? 105.365 114.437 116.189 1.00 74.10  ? 255 ASN B CG  1 
ATOM 6339 O OD1 . ASN B 1 255 ? 104.670 113.852 115.358 1.00 69.83  ? 255 ASN B OD1 1 
ATOM 6340 N ND2 . ASN B 1 255 ? 105.542 113.981 117.422 1.00 73.28  ? 255 ASN B ND2 1 
ATOM 6341 N N   . MET B 1 256 ? 108.400 117.414 113.917 1.00 71.31  ? 256 MET B N   1 
ATOM 6342 C CA  . MET B 1 256 ? 108.494 118.261 112.726 1.00 73.63  ? 256 MET B CA  1 
ATOM 6343 C C   . MET B 1 256 ? 109.141 117.546 111.548 1.00 72.10  ? 256 MET B C   1 
ATOM 6344 O O   . MET B 1 256 ? 108.845 117.885 110.397 1.00 72.07  ? 256 MET B O   1 
ATOM 6345 C CB  . MET B 1 256 ? 109.277 119.549 112.986 1.00 73.75  ? 256 MET B CB  1 
ATOM 6346 C CG  . MET B 1 256 ? 110.478 119.394 113.880 1.00 70.03  ? 256 MET B CG  1 
ATOM 6347 S SD  . MET B 1 256 ? 109.965 118.952 115.533 1.00 72.34  ? 256 MET B SD  1 
ATOM 6348 C CE  . MET B 1 256 ? 109.235 120.506 116.036 1.00 75.73  ? 256 MET B CE  1 
ATOM 6349 N N   . ALA B 1 257 ? 110.020 116.575 111.803 1.00 70.60  ? 257 ALA B N   1 
ATOM 6350 C CA  . ALA B 1 257 ? 110.634 115.828 110.713 1.00 73.35  ? 257 ALA B CA  1 
ATOM 6351 C C   . ALA B 1 257 ? 109.650 114.886 110.034 1.00 79.57  ? 257 ALA B C   1 
ATOM 6352 O O   . ALA B 1 257 ? 109.906 114.448 108.908 1.00 71.80  ? 257 ALA B O   1 
ATOM 6353 C CB  . ALA B 1 257 ? 111.840 115.040 111.226 1.00 67.30  ? 257 ALA B CB  1 
ATOM 6354 N N   . SER B 1 258 ? 108.536 114.571 110.690 1.00 68.10  ? 258 SER B N   1 
ATOM 6355 C CA  . SER B 1 258 ? 107.508 113.737 110.091 1.00 63.09  ? 258 SER B CA  1 
ATOM 6356 C C   . SER B 1 258 ? 106.740 114.512 109.025 1.00 67.47  ? 258 SER B C   1 
ATOM 6357 O O   . SER B 1 258 ? 106.831 115.738 108.918 1.00 67.39  ? 258 SER B O   1 
ATOM 6358 C CB  . SER B 1 258 ? 106.546 113.228 111.162 1.00 66.34  ? 258 SER B CB  1 
ATOM 6359 O OG  . SER B 1 258 ? 105.885 114.302 111.806 1.00 64.61  ? 258 SER B OG  1 
ATOM 6360 N N   . ALA B 1 259 ? 105.970 113.776 108.227 1.00 66.86  ? 259 ALA B N   1 
ATOM 6361 C CA  . ALA B 1 259 ? 105.169 114.380 107.175 1.00 69.62  ? 259 ALA B CA  1 
ATOM 6362 C C   . ALA B 1 259 ? 103.860 114.921 107.751 1.00 71.50  ? 259 ALA B C   1 
ATOM 6363 O O   . ALA B 1 259 ? 103.575 114.802 108.946 1.00 71.48  ? 259 ALA B O   1 
ATOM 6364 C CB  . ALA B 1 259 ? 104.911 113.369 106.061 1.00 67.78  ? 259 ALA B CB  1 
ATOM 6365 N N   . THR B 1 260 ? 103.053 115.532 106.887 1.00 70.01  ? 260 THR B N   1 
ATOM 6366 C CA  . THR B 1 260 ? 101.775 116.093 107.297 1.00 66.59  ? 260 THR B CA  1 
ATOM 6367 C C   . THR B 1 260 ? 100.731 114.993 107.467 1.00 67.67  ? 260 THR B C   1 
ATOM 6368 O O   . THR B 1 260 ? 100.838 113.902 106.898 1.00 65.01  ? 260 THR B O   1 
ATOM 6369 C CB  . THR B 1 260 ? 101.284 117.122 106.278 1.00 67.57  ? 260 THR B CB  1 
ATOM 6370 O OG1 . THR B 1 260 ? 100.684 116.447 105.165 1.00 70.83  ? 260 THR B OG1 1 
ATOM 6371 C CG2 . THR B 1 260 ? 102.443 117.974 105.782 1.00 68.37  ? 260 THR B CG2 1 
ATOM 6372 N N   . VAL B 1 261 ? 99.702  115.296 108.258 1.00 70.28  ? 261 VAL B N   1 
ATOM 6373 C CA  . VAL B 1 261 ? 98.656  114.327 108.564 1.00 71.86  ? 261 VAL B CA  1 
ATOM 6374 C C   . VAL B 1 261 ? 97.394  115.096 108.927 1.00 65.53  ? 261 VAL B C   1 
ATOM 6375 O O   . VAL B 1 261 ? 97.437  116.293 109.219 1.00 62.52  ? 261 VAL B O   1 
ATOM 6376 C CB  . VAL B 1 261 ? 99.091  113.384 109.715 1.00 63.34  ? 261 VAL B CB  1 
ATOM 6377 C CG1 . VAL B 1 261 ? 98.815  114.030 111.076 1.00 63.50  ? 261 VAL B CG1 1 
ATOM 6378 C CG2 . VAL B 1 261 ? 98.445  112.007 109.585 1.00 55.60  ? 261 VAL B CG2 1 
ATOM 6379 N N   . ARG B 1 262 ? 96.257  114.413 108.873 1.00 50.39  ? 262 ARG B N   1 
ATOM 6380 C CA  . ARG B 1 262 ? 95.017  114.909 109.454 1.00 51.45  ? 262 ARG B CA  1 
ATOM 6381 C C   . ARG B 1 262 ? 94.322  113.886 110.337 1.00 52.88  ? 262 ARG B C   1 
ATOM 6382 O O   . ARG B 1 262 ? 93.682  114.264 111.322 1.00 62.10  ? 262 ARG B O   1 
ATOM 6383 C CB  . ARG B 1 262 ? 94.065  115.379 108.346 1.00 61.14  ? 262 ARG B CB  1 
ATOM 6384 C CG  . ARG B 1 262 ? 93.792  114.354 107.268 1.00 60.04  ? 262 ARG B CG  1 
ATOM 6385 C CD  . ARG B 1 262 ? 93.785  115.007 105.902 1.00 59.55  ? 262 ARG B CD  1 
ATOM 6386 N NE  . ARG B 1 262 ? 95.138  115.200 105.394 1.00 53.11  ? 262 ARG B NE  1 
ATOM 6387 C CZ  . ARG B 1 262 ? 95.438  115.922 104.323 1.00 54.80  ? 262 ARG B CZ  1 
ATOM 6388 N NH1 . ARG B 1 262 ? 94.502  116.537 103.620 1.00 60.85  ? 262 ARG B NH1 1 
ATOM 6389 N NH2 . ARG B 1 262 ? 96.709  116.022 103.944 1.00 47.86  ? 262 ARG B NH2 1 
ATOM 6390 N N   . VAL B 1 263 ? 94.440  112.599 110.023 1.00 42.20  ? 263 VAL B N   1 
ATOM 6391 C CA  . VAL B 1 263 ? 93.777  111.536 110.769 1.00 40.13  ? 263 VAL B CA  1 
ATOM 6392 C C   . VAL B 1 263 ? 94.826  110.904 111.676 1.00 32.46  ? 263 VAL B C   1 
ATOM 6393 O O   . VAL B 1 263 ? 95.647  110.098 111.232 1.00 37.23  ? 263 VAL B O   1 
ATOM 6394 C CB  . VAL B 1 263 ? 93.140  110.504 109.836 1.00 34.27  ? 263 VAL B CB  1 
ATOM 6395 C CG1 . VAL B 1 263 ? 92.178  109.622 110.602 1.00 36.60  ? 263 VAL B CG1 1 
ATOM 6396 C CG2 . VAL B 1 263 ? 92.431  111.194 108.689 1.00 34.18  ? 263 VAL B CG2 1 
ATOM 6397 N N   . SER B 1 264 ? 94.803  111.273 112.953 1.00 33.87  ? 264 SER B N   1 
ATOM 6398 C CA  . SER B 1 264 ? 95.713  110.727 113.953 1.00 36.81  ? 264 SER B CA  1 
ATOM 6399 C C   . SER B 1 264 ? 94.949  110.399 115.224 1.00 32.77  ? 264 SER B C   1 
ATOM 6400 O O   . SER B 1 264 ? 95.388  110.709 116.335 1.00 33.74  ? 264 SER B O   1 
ATOM 6401 C CB  . SER B 1 264 ? 96.859  111.691 114.250 1.00 36.02  ? 264 SER B CB  1 
ATOM 6402 O OG  . SER B 1 264 ? 97.691  111.187 115.280 1.00 22.33  ? 264 SER B OG  1 
ATOM 6403 N N   . ARG B 1 265 ? 93.798  109.759 115.071 1.00 23.92  ? 265 ARG B N   1 
ATOM 6404 C CA  . ARG B 1 265 ? 92.835  109.594 116.147 1.00 33.39  ? 265 ARG B CA  1 
ATOM 6405 C C   . ARG B 1 265 ? 92.919  108.205 116.761 1.00 26.34  ? 265 ARG B C   1 
ATOM 6406 O O   . ARG B 1 265 ? 93.059  107.200 116.061 1.00 30.09  ? 265 ARG B O   1 
ATOM 6407 C CB  . ARG B 1 265 ? 91.419  109.835 115.626 1.00 43.74  ? 265 ARG B CB  1 
ATOM 6408 C CG  . ARG B 1 265 ? 91.272  109.526 114.150 1.00 39.36  ? 265 ARG B CG  1 
ATOM 6409 C CD  . ARG B 1 265 ? 89.859  109.764 113.684 1.00 41.67  ? 265 ARG B CD  1 
ATOM 6410 N NE  . ARG B 1 265 ? 88.917  108.980 114.468 1.00 39.72  ? 265 ARG B NE  1 
ATOM 6411 C CZ  . ARG B 1 265 ? 87.797  109.460 114.984 1.00 40.15  ? 265 ARG B CZ  1 
ATOM 6412 N NH1 . ARG B 1 265 ? 87.443  110.723 114.813 1.00 45.54  ? 265 ARG B NH1 1 
ATOM 6413 N NH2 . ARG B 1 265 ? 87.012  108.655 115.691 1.00 38.41  ? 265 ARG B NH2 1 
ATOM 6414 N N   . LEU B 1 266 ? 92.821  108.162 118.085 1.00 17.85  ? 266 LEU B N   1 
ATOM 6415 C CA  . LEU B 1 266 ? 92.755  106.909 118.814 1.00 20.59  ? 266 LEU B CA  1 
ATOM 6416 C C   . LEU B 1 266 ? 91.362  106.297 118.683 1.00 27.19  ? 266 LEU B C   1 
ATOM 6417 O O   . LEU B 1 266 ? 90.410  106.939 118.238 1.00 33.03  ? 266 LEU B O   1 
ATOM 6418 C CB  . LEU B 1 266 ? 93.100  107.127 120.287 1.00 25.74  ? 266 LEU B CB  1 
ATOM 6419 C CG  . LEU B 1 266 ? 94.569  107.256 120.696 1.00 39.72  ? 266 LEU B CG  1 
ATOM 6420 C CD1 . LEU B 1 266 ? 95.092  108.665 120.476 1.00 35.95  ? 266 LEU B CD1 1 
ATOM 6421 C CD2 . LEU B 1 266 ? 94.738  106.853 122.149 1.00 34.68  ? 266 LEU B CD2 1 
ATOM 6422 N N   . LEU B 1 267 ? 91.251  105.029 119.069 1.00 28.31  ? 267 LEU B N   1 
ATOM 6423 C CA  . LEU B 1 267 ? 89.976  104.329 119.101 1.00 27.37  ? 267 LEU B CA  1 
ATOM 6424 C C   . LEU B 1 267 ? 89.822  103.675 120.466 1.00 32.04  ? 267 LEU B C   1 
ATOM 6425 O O   . LEU B 1 267 ? 90.713  103.749 121.316 1.00 38.80  ? 267 LEU B O   1 
ATOM 6426 C CB  . LEU B 1 267 ? 89.874  103.287 117.983 1.00 22.83  ? 267 LEU B CB  1 
ATOM 6427 C CG  . LEU B 1 267 ? 89.293  103.677 116.624 1.00 24.98  ? 267 LEU B CG  1 
ATOM 6428 C CD1 . LEU B 1 267 ? 90.221  104.591 115.848 1.00 17.47  ? 267 LEU B CD1 1 
ATOM 6429 C CD2 . LEU B 1 267 ? 89.006  102.424 115.826 1.00 42.55  ? 267 LEU B CD2 1 
ATOM 6430 N N   . SER B 1 268 ? 88.677  103.028 120.677 1.00 38.66  ? 268 SER B N   1 
ATOM 6431 C CA  . SER B 1 268 ? 88.408  102.342 121.941 1.00 47.67  ? 268 SER B CA  1 
ATOM 6432 C C   . SER B 1 268 ? 87.454  101.191 121.638 1.00 54.28  ? 268 SER B C   1 
ATOM 6433 O O   . SER B 1 268 ? 86.255  101.411 121.445 1.00 52.03  ? 268 SER B O   1 
ATOM 6434 C CB  . SER B 1 268 ? 87.828  103.294 122.977 1.00 50.73  ? 268 SER B CB  1 
ATOM 6435 O OG  . SER B 1 268 ? 87.727  102.668 124.244 1.00 54.85  ? 268 SER B OG  1 
ATOM 6436 N N   . LEU B 1 269 ? 87.991  99.979  121.595 1.00 63.78  ? 269 LEU B N   1 
ATOM 6437 C CA  . LEU B 1 269 ? 87.187  98.827  121.227 1.00 61.91  ? 269 LEU B CA  1 
ATOM 6438 C C   . LEU B 1 269 ? 86.356  98.335  122.411 1.00 68.20  ? 269 LEU B C   1 
ATOM 6439 O O   . LEU B 1 269 ? 86.784  98.436  123.564 1.00 70.55  ? 269 LEU B O   1 
ATOM 6440 C CB  . LEU B 1 269 ? 88.079  97.704  120.709 1.00 57.97  ? 269 LEU B CB  1 
ATOM 6441 C CG  . LEU B 1 269 ? 88.925  98.062  119.487 1.00 61.12  ? 269 LEU B CG  1 
ATOM 6442 C CD1 . LEU B 1 269 ? 89.504  96.812  118.858 1.00 66.45  ? 269 LEU B CD1 1 
ATOM 6443 C CD2 . LEU B 1 269 ? 88.106  98.841  118.472 1.00 53.41  ? 269 LEU B CD2 1 
ATOM 6444 N N   . PRO B 1 270 ? 85.161  97.808  122.152 1.00 80.24  ? 270 PRO B N   1 
ATOM 6445 C CA  . PRO B 1 270 ? 84.320  97.302  123.242 1.00 83.89  ? 270 PRO B CA  1 
ATOM 6446 C C   . PRO B 1 270 ? 84.873  96.004  123.803 1.00 82.96  ? 270 PRO B C   1 
ATOM 6447 O O   . PRO B 1 270 ? 85.336  95.136  123.048 1.00 73.57  ? 270 PRO B O   1 
ATOM 6448 C CB  . PRO B 1 270 ? 82.959  97.083  122.564 1.00 78.12  ? 270 PRO B CB  1 
ATOM 6449 C CG  . PRO B 1 270 ? 83.285  96.875  121.127 1.00 74.83  ? 270 PRO B CG  1 
ATOM 6450 C CD  . PRO B 1 270 ? 84.474  97.745  120.849 1.00 76.18  ? 270 PRO B CD  1 
ATOM 6451 N N   . PRO B 1 271 ? 84.842  95.831  125.135 1.00 77.74  ? 271 PRO B N   1 
ATOM 6452 C CA  . PRO B 1 271 ? 85.320  94.595  125.771 1.00 78.37  ? 271 PRO B CA  1 
ATOM 6453 C C   . PRO B 1 271 ? 84.268  93.488  125.823 1.00 76.16  ? 271 PRO B C   1 
ATOM 6454 O O   . PRO B 1 271 ? 84.013  92.896  126.872 1.00 79.97  ? 271 PRO B O   1 
ATOM 6455 C CB  . PRO B 1 271 ? 85.714  95.065  127.175 1.00 79.34  ? 271 PRO B CB  1 
ATOM 6456 C CG  . PRO B 1 271 ? 85.496  96.570  127.205 1.00 76.13  ? 271 PRO B CG  1 
ATOM 6457 C CD  . PRO B 1 271 ? 84.513  96.857  126.133 1.00 80.24  ? 271 PRO B CD  1 
ATOM 6458 N N   . GLU B 1 272 ? 83.653  93.205  124.677 1.00 74.05  ? 272 GLU B N   1 
ATOM 6459 C CA  . GLU B 1 272 ? 82.646  92.162  124.573 1.00 70.67  ? 272 GLU B CA  1 
ATOM 6460 C C   . GLU B 1 272 ? 82.942  91.305  123.351 1.00 73.15  ? 272 GLU B C   1 
ATOM 6461 O O   . GLU B 1 272 ? 83.491  91.786  122.356 1.00 73.01  ? 272 GLU B O   1 
ATOM 6462 C CB  . GLU B 1 272 ? 81.231  92.750  124.484 1.00 73.75  ? 272 GLU B CB  1 
ATOM 6463 C CG  . GLU B 1 272 ? 80.165  91.923  125.186 1.00 76.92  ? 272 GLU B CG  1 
ATOM 6464 C CD  . GLU B 1 272 ? 78.828  92.634  125.253 1.00 77.49  ? 272 GLU B CD  1 
ATOM 6465 O OE1 . GLU B 1 272 ? 78.725  93.762  124.726 1.00 73.83  ? 272 GLU B OE1 1 
ATOM 6466 O OE2 . GLU B 1 272 ? 77.879  92.066  125.834 1.00 79.71  ? 272 GLU B OE2 1 
ATOM 6467 N N   . ALA B 1 273 ? 82.567  90.032  123.434 1.00 66.30  ? 273 ALA B N   1 
ATOM 6468 C CA  . ALA B 1 273 ? 82.881  89.067  122.391 1.00 68.32  ? 273 ALA B CA  1 
ATOM 6469 C C   . ALA B 1 273 ? 82.008  89.274  121.158 1.00 61.18  ? 273 ALA B C   1 
ATOM 6470 O O   . ALA B 1 273 ? 80.899  89.809  121.236 1.00 65.42  ? 273 ALA B O   1 
ATOM 6471 C CB  . ALA B 1 273 ? 82.697  87.644  122.913 1.00 66.04  ? 273 ALA B CB  1 
ATOM 6472 N N   . PHE B 1 274 ? 82.522  88.837  120.010 1.00 53.56  ? 274 PHE B N   1 
ATOM 6473 C CA  . PHE B 1 274 ? 81.746  88.833  118.779 1.00 52.72  ? 274 PHE B CA  1 
ATOM 6474 C C   . PHE B 1 274 ? 82.209  87.675  117.902 1.00 56.58  ? 274 PHE B C   1 
ATOM 6475 O O   . PHE B 1 274 ? 83.044  86.859  118.300 1.00 59.67  ? 274 PHE B O   1 
ATOM 6476 C CB  . PHE B 1 274 ? 81.823  90.189  118.063 1.00 59.01  ? 274 PHE B CB  1 
ATOM 6477 C CG  . PHE B 1 274 ? 83.133  90.460  117.377 1.00 59.48  ? 274 PHE B CG  1 
ATOM 6478 C CD1 . PHE B 1 274 ? 84.223  90.921  118.094 1.00 60.60  ? 274 PHE B CD1 1 
ATOM 6479 C CD2 . PHE B 1 274 ? 83.262  90.288  116.007 1.00 57.64  ? 274 PHE B CD2 1 
ATOM 6480 C CE1 . PHE B 1 274 ? 85.418  91.190  117.460 1.00 60.43  ? 274 PHE B CE1 1 
ATOM 6481 C CE2 . PHE B 1 274 ? 84.456  90.545  115.372 1.00 55.24  ? 274 PHE B CE2 1 
ATOM 6482 C CZ  . PHE B 1 274 ? 85.535  90.994  116.100 1.00 55.12  ? 274 PHE B CZ  1 
ATOM 6483 N N   . GLU B 1 275 ? 81.656  87.619  116.692 1.00 63.01  ? 275 GLU B N   1 
ATOM 6484 C CA  . GLU B 1 275 ? 81.670  86.438  115.840 1.00 68.98  ? 275 GLU B CA  1 
ATOM 6485 C C   . GLU B 1 275 ? 82.498  86.671  114.580 1.00 70.89  ? 275 GLU B C   1 
ATOM 6486 O O   . GLU B 1 275 ? 82.559  87.790  114.062 1.00 68.39  ? 275 GLU B O   1 
ATOM 6487 C CB  . GLU B 1 275 ? 80.224  86.067  115.471 1.00 68.13  ? 275 GLU B CB  1 
ATOM 6488 C CG  . GLU B 1 275 ? 80.047  84.877  114.556 1.00 68.02  ? 275 GLU B CG  1 
ATOM 6489 C CD  . GLU B 1 275 ? 79.773  85.320  113.136 1.00 70.65  ? 275 GLU B CD  1 
ATOM 6490 O OE1 . GLU B 1 275 ? 79.755  86.543  112.891 1.00 69.76  ? 275 GLU B OE1 1 
ATOM 6491 O OE2 . GLU B 1 275 ? 79.579  84.458  112.262 1.00 73.35  ? 275 GLU B OE2 1 
ATOM 6492 N N   . MET B 1 276 ? 83.149  85.590  114.090 1.00 74.32  ? 276 MET B N   1 
ATOM 6493 C CA  . MET B 1 276 ? 83.812  85.483  112.796 1.00 72.05  ? 276 MET B CA  1 
ATOM 6494 C C   . MET B 1 276 ? 83.308  84.293  111.989 1.00 72.41  ? 276 MET B C   1 
ATOM 6495 O O   . MET B 1 276 ? 82.789  83.322  112.548 1.00 76.97  ? 276 MET B O   1 
ATOM 6496 C CB  . MET B 1 276 ? 85.334  85.333  112.898 1.00 72.11  ? 276 MET B CB  1 
ATOM 6497 C CG  . MET B 1 276 ? 85.869  84.801  114.181 1.00 72.11  ? 276 MET B CG  1 
ATOM 6498 S SD  . MET B 1 276 ? 87.568  85.358  114.248 1.00 74.65  ? 276 MET B SD  1 
ATOM 6499 C CE  . MET B 1 276 ? 87.349  86.930  115.006 1.00 64.98  ? 276 MET B CE  1 
ATOM 6500 N N   . PRO B 1 277 ? 83.455  84.344  110.668 1.00 73.51  ? 277 PRO B N   1 
ATOM 6501 C CA  . PRO B 1 277 ? 83.390  83.127  109.858 1.00 79.09  ? 277 PRO B CA  1 
ATOM 6502 C C   . PRO B 1 277 ? 84.749  82.437  109.812 1.00 79.96  ? 277 PRO B C   1 
ATOM 6503 O O   . PRO B 1 277 ? 85.749  82.932  110.332 1.00 79.10  ? 277 PRO B O   1 
ATOM 6504 C CB  . PRO B 1 277 ? 82.992  83.649  108.476 1.00 77.95  ? 277 PRO B CB  1 
ATOM 6505 C CG  . PRO B 1 277 ? 83.572  85.020  108.431 1.00 72.81  ? 277 PRO B CG  1 
ATOM 6506 C CD  . PRO B 1 277 ? 83.472  85.559  109.831 1.00 71.53  ? 277 PRO B CD  1 
ATOM 6507 N N   . LEU B 1 278 ? 84.763  81.269  109.176 1.00 86.21  ? 278 LEU B N   1 
ATOM 6508 C CA  . LEU B 1 278 ? 85.989  80.545  108.870 1.00 86.07  ? 278 LEU B CA  1 
ATOM 6509 C C   . LEU B 1 278 ? 86.105  80.381  107.363 1.00 87.04  ? 278 LEU B C   1 
ATOM 6510 O O   . LEU B 1 278 ? 85.111  80.110  106.682 1.00 85.79  ? 278 LEU B O   1 
ATOM 6511 C CB  . LEU B 1 278 ? 86.031  79.159  109.530 1.00 84.13  ? 278 LEU B CB  1 
ATOM 6512 C CG  . LEU B 1 278 ? 85.793  78.982  111.030 1.00 86.69  ? 278 LEU B CG  1 
ATOM 6513 C CD1 . LEU B 1 278 ? 84.324  78.759  111.336 1.00 85.06  ? 278 LEU B CD1 1 
ATOM 6514 C CD2 . LEU B 1 278 ? 86.626  77.830  111.570 1.00 86.63  ? 278 LEU B CD2 1 
ATOM 6515 N N   . THR B 1 279 ? 87.321  80.542  106.842 1.00 94.62  ? 279 THR B N   1 
ATOM 6516 C CA  . THR B 1 279 ? 87.543  80.348  105.415 1.00 94.66  ? 279 THR B CA  1 
ATOM 6517 C C   . THR B 1 279 ? 87.594  78.878  105.020 1.00 94.39  ? 279 THR B C   1 
ATOM 6518 O O   . THR B 1 279 ? 87.563  78.578  103.821 1.00 95.29  ? 279 THR B O   1 
ATOM 6519 C CB  . THR B 1 279 ? 88.831  81.054  104.973 1.00 92.07  ? 279 THR B CB  1 
ATOM 6520 O OG1 . THR B 1 279 ? 88.786  81.290  103.559 1.00 91.86  ? 279 THR B OG1 1 
ATOM 6521 C CG2 . THR B 1 279 ? 90.060  80.217  105.307 1.00 91.95  ? 279 THR B CG2 1 
ATOM 6522 N N   . ALA B 1 280 ? 87.679  77.962  105.989 1.00 91.05  ? 280 ALA B N   1 
ATOM 6523 C CA  . ALA B 1 280 ? 87.555  76.542  105.677 1.00 90.72  ? 280 ALA B CA  1 
ATOM 6524 C C   . ALA B 1 280 ? 86.145  76.208  105.209 1.00 90.20  ? 280 ALA B C   1 
ATOM 6525 O O   . ALA B 1 280 ? 85.963  75.419  104.274 1.00 90.18  ? 280 ALA B O   1 
ATOM 6526 C CB  . ALA B 1 280 ? 87.933  75.701  106.895 1.00 90.09  ? 280 ALA B CB  1 
ATOM 6527 N N   . ASP B 1 281 ? 85.139  76.799  105.848 1.00 91.39  ? 281 ASP B N   1 
ATOM 6528 C CA  . ASP B 1 281 ? 83.746  76.672  105.443 1.00 93.64  ? 281 ASP B CA  1 
ATOM 6529 C C   . ASP B 1 281 ? 82.988  77.912  105.901 1.00 94.67  ? 281 ASP B C   1 
ATOM 6530 O O   . ASP B 1 281 ? 82.838  78.134  107.110 1.00 94.05  ? 281 ASP B O   1 
ATOM 6531 C CB  . ASP B 1 281 ? 83.123  75.402  106.022 1.00 91.47  ? 281 ASP B CB  1 
ATOM 6532 C CG  . ASP B 1 281 ? 81.889  74.957  105.260 1.00 92.03  ? 281 ASP B CG  1 
ATOM 6533 O OD1 . ASP B 1 281 ? 80.858  75.659  105.331 1.00 91.48  ? 281 ASP B OD1 1 
ATOM 6534 O OD2 . ASP B 1 281 ? 81.949  73.905  104.590 1.00 91.52  ? 281 ASP B OD2 1 
ATOM 6535 N N   . PRO B 1 282 ? 82.519  78.750  104.972 1.00 95.84  ? 282 PRO B N   1 
ATOM 6536 C CA  . PRO B 1 282 ? 81.847  80.000  105.372 1.00 92.91  ? 282 PRO B CA  1 
ATOM 6537 C C   . PRO B 1 282 ? 80.533  79.798  106.112 1.00 91.74  ? 282 PRO B C   1 
ATOM 6538 O O   . PRO B 1 282 ? 80.094  80.716  106.816 1.00 91.72  ? 282 PRO B O   1 
ATOM 6539 C CB  . PRO B 1 282 ? 81.626  80.722  104.035 1.00 93.44  ? 282 PRO B CB  1 
ATOM 6540 C CG  . PRO B 1 282 ? 82.608  80.097  103.089 1.00 91.86  ? 282 PRO B CG  1 
ATOM 6541 C CD  . PRO B 1 282 ? 82.704  78.666  103.515 1.00 91.84  ? 282 PRO B CD  1 
ATOM 6542 N N   . THR B 1 283 ? 79.890  78.635  105.979 1.00 90.95  ? 283 THR B N   1 
ATOM 6543 C CA  . THR B 1 283 ? 78.608  78.415  106.640 0.73 91.76  ? 283 THR B CA  1 
ATOM 6544 C C   . THR B 1 283 ? 78.750  78.218  108.144 1.00 91.72  ? 283 THR B C   1 
ATOM 6545 O O   . THR B 1 283 ? 77.835  78.582  108.890 1.00 90.74  ? 283 THR B O   1 
ATOM 6546 C CB  . THR B 1 283 ? 77.895  77.210  106.026 1.00 90.91  ? 283 THR B CB  1 
ATOM 6547 O OG1 . THR B 1 283 ? 78.499  76.001  106.499 1.00 93.03  ? 283 THR B OG1 1 
ATOM 6548 C CG2 . THR B 1 283 ? 77.981  77.259  104.508 1.00 92.19  ? 283 THR B CG2 1 
ATOM 6549 N N   . LEU B 1 284 ? 79.860  77.654  108.607 1.00 87.50  ? 284 LEU B N   1 
ATOM 6550 C CA  . LEU B 1 284 ? 80.103  77.487  110.031 1.00 88.28  ? 284 LEU B CA  1 
ATOM 6551 C C   . LEU B 1 284 ? 80.804  78.716  110.597 1.00 89.20  ? 284 LEU B C   1 
ATOM 6552 O O   . LEU B 1 284 ? 81.485  79.460  109.886 1.00 87.34  ? 284 LEU B O   1 
ATOM 6553 C CB  . LEU B 1 284 ? 80.921  76.223  110.316 1.00 87.14  ? 284 LEU B CB  1 
ATOM 6554 C CG  . LEU B 1 284 ? 80.264  74.885  109.955 1.00 86.43  ? 284 LEU B CG  1 
ATOM 6555 C CD1 . LEU B 1 284 ? 80.644  74.409  108.562 1.00 87.29  ? 284 LEU B CD1 1 
ATOM 6556 C CD2 . LEU B 1 284 ? 80.599  73.826  110.996 1.00 87.65  ? 284 LEU B CD2 1 
ATOM 6557 N N   . THR B 1 285 ? 80.606  78.932  111.898 1.00 86.51  ? 285 THR B N   1 
ATOM 6558 C CA  . THR B 1 285 ? 80.970  80.178  112.557 1.00 83.14  ? 285 THR B CA  1 
ATOM 6559 C C   . THR B 1 285 ? 81.753  79.868  113.826 1.00 81.56  ? 285 THR B C   1 
ATOM 6560 O O   . THR B 1 285 ? 81.670  78.767  114.374 1.00 87.05  ? 285 THR B O   1 
ATOM 6561 C CB  . THR B 1 285 ? 79.724  81.004  112.910 1.00 83.04  ? 285 THR B CB  1 
ATOM 6562 O OG1 . THR B 1 285 ? 78.852  80.216  113.730 1.00 84.29  ? 285 THR B OG1 1 
ATOM 6563 C CG2 . THR B 1 285 ? 78.959  81.394  111.648 1.00 83.21  ? 285 THR B CG2 1 
ATOM 6564 N N   . VAL B 1 286 ? 82.518  80.854  114.294 1.00 73.47  ? 286 VAL B N   1 
ATOM 6565 C CA  . VAL B 1 286 ? 83.279  80.739  115.535 1.00 74.82  ? 286 VAL B CA  1 
ATOM 6566 C C   . VAL B 1 286 ? 83.269  82.087  116.252 1.00 80.78  ? 286 VAL B C   1 
ATOM 6567 O O   . VAL B 1 286 ? 83.403  83.140  115.622 1.00 84.83  ? 286 VAL B O   1 
ATOM 6568 C CB  . VAL B 1 286 ? 84.714  80.222  115.263 1.00 75.47  ? 286 VAL B CB  1 
ATOM 6569 C CG1 . VAL B 1 286 ? 85.345  80.961  114.116 1.00 75.58  ? 286 VAL B CG1 1 
ATOM 6570 C CG2 . VAL B 1 286 ? 85.600  80.326  116.498 1.00 77.65  ? 286 VAL B CG2 1 
ATOM 6571 N N   . THR B 1 287 ? 83.070  82.048  117.571 1.00 86.13  ? 287 THR B N   1 
ATOM 6572 C CA  . THR B 1 287 ? 83.007  83.230  118.421 1.00 86.13  ? 287 THR B CA  1 
ATOM 6573 C C   . THR B 1 287 ? 84.299  83.373  119.218 1.00 84.92  ? 287 THR B C   1 
ATOM 6574 O O   . THR B 1 287 ? 84.871  82.376  119.670 1.00 83.53  ? 287 THR B O   1 
ATOM 6575 C CB  . THR B 1 287 ? 81.813  83.131  119.376 1.00 84.86  ? 287 THR B CB  1 
ATOM 6576 O OG1 . THR B 1 287 ? 80.666  82.654  118.661 1.00 85.55  ? 287 THR B OG1 1 
ATOM 6577 C CG2 . THR B 1 287 ? 81.487  84.482  120.001 1.00 84.28  ? 287 THR B CG2 1 
ATOM 6578 N N   . ILE B 1 288 ? 84.757  84.616  119.394 1.00 80.32  ? 288 ILE B N   1 
ATOM 6579 C CA  . ILE B 1 288 ? 85.970  84.862  120.168 1.00 83.47  ? 288 ILE B CA  1 
ATOM 6580 C C   . ILE B 1 288 ? 85.680  84.672  121.649 1.00 86.25  ? 288 ILE B C   1 
ATOM 6581 O O   . ILE B 1 288 ? 84.655  85.135  122.164 1.00 81.12  ? 288 ILE B O   1 
ATOM 6582 C CB  . ILE B 1 288 ? 86.512  86.278  119.928 1.00 79.33  ? 288 ILE B CB  1 
ATOM 6583 C CG1 . ILE B 1 288 ? 86.561  86.621  118.458 1.00 79.44  ? 288 ILE B CG1 1 
ATOM 6584 C CG2 . ILE B 1 288 ? 87.931  86.400  120.442 1.00 76.30  ? 288 ILE B CG2 1 
ATOM 6585 C CD1 . ILE B 1 288 ? 86.874  88.073  118.242 1.00 86.35  ? 288 ILE B CD1 1 
ATOM 6586 N N   . SER B 1 289 ? 86.574  83.997  122.336 1.00 96.83  ? 289 SER B N   1 
ATOM 6587 C CA  . SER B 1 289 ? 86.636  84.160  123.778 1.00 94.46  ? 289 SER B CA  1 
ATOM 6588 C C   . SER B 1 289 ? 87.282  85.506  124.091 1.00 93.48  ? 289 SER B C   1 
ATOM 6589 O O   . SER B 1 289 ? 88.359  85.800  123.561 1.00 91.31  ? 289 SER B O   1 
ATOM 6590 C CB  . SER B 1 289 ? 87.433  83.026  124.413 1.00 89.97  ? 289 SER B CB  1 
ATOM 6591 O OG  . SER B 1 289 ? 86.822  81.774  124.155 1.00 90.09  ? 289 SER B OG  1 
ATOM 6592 N N   . PRO B 1 290 ? 86.656  86.346  124.915 1.00 79.79  ? 290 PRO B N   1 
ATOM 6593 C CA  . PRO B 1 290 ? 87.211  87.676  125.166 1.00 79.04  ? 290 PRO B CA  1 
ATOM 6594 C C   . PRO B 1 290 ? 88.545  87.578  125.883 1.00 78.43  ? 290 PRO B C   1 
ATOM 6595 O O   . PRO B 1 290 ? 88.803  86.608  126.617 1.00 76.33  ? 290 PRO B O   1 
ATOM 6596 C CB  . PRO B 1 290 ? 86.148  88.344  126.050 1.00 79.00  ? 290 PRO B CB  1 
ATOM 6597 C CG  . PRO B 1 290 ? 84.912  87.527  125.876 1.00 80.66  ? 290 PRO B CG  1 
ATOM 6598 C CD  . PRO B 1 290 ? 85.380  86.135  125.617 1.00 77.99  ? 290 PRO B CD  1 
ATOM 6599 N N   . PRO B 1 291 ? 89.440  88.547  125.668 1.00 75.84  ? 291 PRO B N   1 
ATOM 6600 C CA  . PRO B 1 291 ? 90.745  88.488  126.335 1.00 75.67  ? 291 PRO B CA  1 
ATOM 6601 C C   . PRO B 1 291 ? 90.618  88.759  127.824 1.00 77.23  ? 291 PRO B C   1 
ATOM 6602 O O   . PRO B 1 291 ? 90.433  89.904  128.246 1.00 77.00  ? 291 PRO B O   1 
ATOM 6603 C CB  . PRO B 1 291 ? 91.557  89.577  125.624 1.00 68.39  ? 291 PRO B CB  1 
ATOM 6604 C CG  . PRO B 1 291 ? 90.547  90.509  125.068 1.00 65.82  ? 291 PRO B CG  1 
ATOM 6605 C CD  . PRO B 1 291 ? 89.350  89.676  124.726 1.00 71.57  ? 291 PRO B CD  1 
ATOM 6606 N N   . LEU B 1 292 ? 90.722  87.705  128.631 1.00 69.27  ? 292 LEU B N   1 
ATOM 6607 C CA  . LEU B 1 292 ? 90.567  87.836  130.076 1.00 71.26  ? 292 LEU B CA  1 
ATOM 6608 C C   . LEU B 1 292 ? 91.912  88.005  130.774 1.00 70.87  ? 292 LEU B C   1 
ATOM 6609 O O   . LEU B 1 292 ? 92.136  89.009  131.458 1.00 69.68  ? 292 LEU B O   1 
ATOM 6610 C CB  . LEU B 1 292 ? 89.829  86.617  130.643 1.00 67.34  ? 292 LEU B CB  1 
ATOM 6611 C CG  . LEU B 1 292 ? 88.649  86.061  129.844 1.00 68.11  ? 292 LEU B CG  1 
ATOM 6612 C CD1 . LEU B 1 292 ? 88.310  84.651  130.300 1.00 66.67  ? 292 LEU B CD1 1 
ATOM 6613 C CD2 . LEU B 1 292 ? 87.439  86.973  129.962 1.00 73.62  ? 292 LEU B CD2 1 
ATOM 6614 N N   . ALA B 1 293 ? 92.808  87.026  130.595 1.00 69.17  ? 293 ALA B N   1 
ATOM 6615 C CA  . ALA B 1 293 ? 94.033  86.874  131.388 1.00 67.57  ? 293 ALA B CA  1 
ATOM 6616 C C   . ALA B 1 293 ? 93.715  86.877  132.881 1.00 67.64  ? 293 ALA B C   1 
ATOM 6617 O O   . ALA B 1 293 ? 94.452  87.444  133.691 1.00 70.36  ? 293 ALA B O   1 
ATOM 6618 C CB  . ALA B 1 293 ? 95.073  87.940  131.039 1.00 63.36  ? 293 ALA B CB  1 
ATOM 6619 N N   . HIS B 1 294 ? 92.601  86.217  133.229 1.00 74.04  ? 294 HIS B N   1 
ATOM 6620 C CA  . HIS B 1 294 ? 91.958  86.150  134.545 1.00 69.13  ? 294 HIS B CA  1 
ATOM 6621 C C   . HIS B 1 294 ? 91.964  87.473  135.308 1.00 67.97  ? 294 HIS B C   1 
ATOM 6622 O O   . HIS B 1 294 ? 92.168  87.490  136.527 1.00 67.78  ? 294 HIS B O   1 
ATOM 6623 C CB  . HIS B 1 294 ? 92.573  85.034  135.408 1.00 67.87  ? 294 HIS B CB  1 
ATOM 6624 C CG  . HIS B 1 294 ? 94.059  85.120  135.574 1.00 67.98  ? 294 HIS B CG  1 
ATOM 6625 N ND1 . HIS B 1 294 ? 94.940  84.513  134.705 1.00 64.91  ? 294 HIS B ND1 1 
ATOM 6626 C CD2 . HIS B 1 294 ? 94.819  85.741  136.507 1.00 67.88  ? 294 HIS B CD2 1 
ATOM 6627 C CE1 . HIS B 1 294 ? 96.178  84.757  135.095 1.00 68.69  ? 294 HIS B CE1 1 
ATOM 6628 N NE2 . HIS B 1 294 ? 96.132  85.500  136.186 1.00 67.89  ? 294 HIS B NE2 1 
ATOM 6629 N N   . THR B 1 295 ? 91.734  88.588  134.605 1.00 65.24  ? 295 THR B N   1 
ATOM 6630 C CA  . THR B 1 295 ? 91.578  89.880  135.260 1.00 65.18  ? 295 THR B CA  1 
ATOM 6631 C C   . THR B 1 295 ? 90.514  90.766  134.623 1.00 69.68  ? 295 THR B C   1 
ATOM 6632 O O   . THR B 1 295 ? 90.361  91.914  135.052 1.00 66.92  ? 295 THR B O   1 
ATOM 6633 C CB  . THR B 1 295 ? 92.916  90.640  135.294 1.00 62.81  ? 295 THR B CB  1 
ATOM 6634 O OG1 . THR B 1 295 ? 92.734  91.903  135.945 1.00 65.33  ? 295 THR B OG1 1 
ATOM 6635 C CG2 . THR B 1 295 ? 93.437  90.875  133.891 1.00 63.90  ? 295 THR B CG2 1 
ATOM 6636 N N   . GLY B 1 296 ? 89.782  90.284  133.621 1.00 68.51  ? 296 GLY B N   1 
ATOM 6637 C CA  . GLY B 1 296 ? 88.708  91.045  133.030 1.00 68.89  ? 296 GLY B CA  1 
ATOM 6638 C C   . GLY B 1 296 ? 89.108  91.745  131.746 1.00 69.20  ? 296 GLY B C   1 
ATOM 6639 O O   . GLY B 1 296 ? 90.168  92.373  131.659 1.00 68.89  ? 296 GLY B O   1 
ATOM 6640 N N   . PRO B 1 297 ? 88.268  91.632  130.715 1.00 77.38  ? 297 PRO B N   1 
ATOM 6641 C CA  . PRO B 1 297 ? 88.536  92.348  129.462 1.00 78.69  ? 297 PRO B CA  1 
ATOM 6642 C C   . PRO B 1 297 ? 88.429  93.855  129.634 1.00 79.87  ? 297 PRO B C   1 
ATOM 6643 O O   . PRO B 1 297 ? 87.643  94.360  130.439 1.00 81.46  ? 297 PRO B O   1 
ATOM 6644 C CB  . PRO B 1 297 ? 87.453  91.814  128.515 1.00 76.32  ? 297 PRO B CB  1 
ATOM 6645 C CG  . PRO B 1 297 ? 86.366  91.347  129.436 1.00 75.14  ? 297 PRO B CG  1 
ATOM 6646 C CD  . PRO B 1 297 ? 87.114  90.729  130.578 1.00 75.79  ? 297 PRO B CD  1 
ATOM 6647 N N   . GLY B 1 298 ? 89.229  94.575  128.854 1.00 75.19  ? 298 GLY B N   1 
ATOM 6648 C CA  . GLY B 1 298 ? 89.257  96.015  128.919 1.00 73.12  ? 298 GLY B CA  1 
ATOM 6649 C C   . GLY B 1 298 ? 89.223  96.651  127.548 1.00 75.12  ? 298 GLY B C   1 
ATOM 6650 O O   . GLY B 1 298 ? 88.836  96.029  126.552 1.00 77.56  ? 298 GLY B O   1 
ATOM 6651 N N   . PRO B 1 299 ? 89.650  97.910  127.466 1.00 72.97  ? 299 PRO B N   1 
ATOM 6652 C CA  . PRO B 1 299 ? 89.638  98.601  126.178 1.00 72.87  ? 299 PRO B CA  1 
ATOM 6653 C C   . PRO B 1 299 ? 90.858  98.342  125.303 1.00 67.42  ? 299 PRO B C   1 
ATOM 6654 O O   . PRO B 1 299 ? 92.002  98.655  125.656 1.00 69.25  ? 299 PRO B O   1 
ATOM 6655 C CB  . PRO B 1 299 ? 89.524  100.063 126.617 1.00 70.94  ? 299 PRO B CB  1 
ATOM 6656 C CG  . PRO B 1 299 ? 90.329  100.106 127.965 1.00 68.08  ? 299 PRO B CG  1 
ATOM 6657 C CD  . PRO B 1 299 ? 90.530  98.639  128.398 1.00 70.40  ? 299 PRO B CD  1 
ATOM 6658 N N   . VAL B 1 300 ? 90.619  97.770  124.126 1.00 58.06  ? 300 VAL B N   1 
ATOM 6659 C CA  . VAL B 1 300 ? 91.714  97.463  123.216 1.00 49.13  ? 300 VAL B CA  1 
ATOM 6660 C C   . VAL B 1 300 ? 92.075  98.786  122.543 1.00 53.73  ? 300 VAL B C   1 
ATOM 6661 O O   . VAL B 1 300 ? 91.411  99.233  121.603 1.00 59.49  ? 300 VAL B O   1 
ATOM 6662 C CB  . VAL B 1 300 ? 91.338  96.378  122.205 1.00 49.02  ? 300 VAL B CB  1 
ATOM 6663 C CG1 . VAL B 1 300 ? 92.334  96.344  121.063 1.00 52.24  ? 300 VAL B CG1 1 
ATOM 6664 C CG2 . VAL B 1 300 ? 91.236  95.026  122.888 1.00 52.81  ? 300 VAL B CG2 1 
ATOM 6665 N N   . LEU B 1 301 ? 93.095  99.452  123.079 1.00 53.53  ? 301 LEU B N   1 
ATOM 6666 C CA  . LEU B 1 301 ? 93.494  100.773 122.608 1.00 50.63  ? 301 LEU B CA  1 
ATOM 6667 C C   . LEU B 1 301 ? 94.210  100.639 121.273 1.00 39.39  ? 301 LEU B C   1 
ATOM 6668 O O   . LEU B 1 301 ? 95.323  100.110 121.203 1.00 40.48  ? 301 LEU B O   1 
ATOM 6669 C CB  . LEU B 1 301 ? 94.384  101.458 123.642 1.00 44.99  ? 301 LEU B CB  1 
ATOM 6670 C CG  . LEU B 1 301 ? 93.754  102.474 124.602 1.00 51.42  ? 301 LEU B CG  1 
ATOM 6671 C CD1 . LEU B 1 301 ? 93.457  103.771 123.875 1.00 45.85  ? 301 LEU B CD1 1 
ATOM 6672 C CD2 . LEU B 1 301 ? 92.495  101.938 125.270 1.00 44.06  ? 301 LEU B CD2 1 
ATOM 6673 N N   . VAL B 1 302 ? 93.571  101.111 120.212 1.00 27.35  ? 302 VAL B N   1 
ATOM 6674 C CA  . VAL B 1 302 ? 94.131  101.092 118.871 1.00 14.70  ? 302 VAL B CA  1 
ATOM 6675 C C   . VAL B 1 302 ? 94.025  102.506 118.332 1.00 20.06  ? 302 VAL B C   1 
ATOM 6676 O O   . VAL B 1 302 ? 93.069  103.219 118.651 1.00 29.74  ? 302 VAL B O   1 
ATOM 6677 C CB  . VAL B 1 302 ? 93.388  100.090 117.974 1.00 18.26  ? 302 VAL B CB  1 
ATOM 6678 C CG1 . VAL B 1 302 ? 93.819  98.700  118.317 1.00 33.04  ? 302 VAL B CG1 1 
ATOM 6679 C CG2 . VAL B 1 302 ? 91.903  100.204 118.180 1.00 28.40  ? 302 VAL B CG2 1 
ATOM 6680 N N   . ARG B 1 303 ? 95.013  102.934 117.559 1.00 11.62  ? 303 ARG B N   1 
ATOM 6681 C CA  . ARG B 1 303 ? 95.007  104.288 117.029 1.00 25.35  ? 303 ARG B CA  1 
ATOM 6682 C C   . ARG B 1 303 ? 95.293  104.284 115.535 1.00 22.25  ? 303 ARG B C   1 
ATOM 6683 O O   . ARG B 1 303 ? 96.174  103.566 115.057 1.00 33.20  ? 303 ARG B O   1 
ATOM 6684 C CB  . ARG B 1 303 ? 95.994  105.180 117.788 1.00 15.18  ? 303 ARG B CB  1 
ATOM 6685 C CG  . ARG B 1 303 ? 97.422  104.708 117.826 1.00 13.38  ? 303 ARG B CG  1 
ATOM 6686 C CD  . ARG B 1 303 ? 98.278  105.754 118.518 1.00 26.05  ? 303 ARG B CD  1 
ATOM 6687 N NE  . ARG B 1 303 ? 98.290  107.018 117.792 1.00 34.89  ? 303 ARG B NE  1 
ATOM 6688 C CZ  . ARG B 1 303 ? 98.967  107.241 116.673 1.00 31.83  ? 303 ARG B CZ  1 
ATOM 6689 N NH1 . ARG B 1 303 ? 99.744  106.313 116.138 1.00 25.35  ? 303 ARG B NH1 1 
ATOM 6690 N NH2 . ARG B 1 303 ? 98.873  108.429 116.084 1.00 27.06  ? 303 ARG B NH2 1 
ATOM 6691 N N   . LEU B 1 304 ? 94.529  105.089 114.807 1.00 24.86  ? 304 LEU B N   1 
ATOM 6692 C CA  . LEU B 1 304 ? 94.531  105.100 113.353 1.00 19.08  ? 304 LEU B CA  1 
ATOM 6693 C C   . LEU B 1 304 ? 95.364  106.259 112.829 1.00 19.80  ? 304 LEU B C   1 
ATOM 6694 O O   . LEU B 1 304 ? 95.198  107.402 113.260 1.00 26.24  ? 304 LEU B O   1 
ATOM 6695 C CB  . LEU B 1 304 ? 93.101  105.212 112.820 1.00 28.68  ? 304 LEU B CB  1 
ATOM 6696 C CG  . LEU B 1 304 ? 92.880  105.252 111.306 1.00 26.64  ? 304 LEU B CG  1 
ATOM 6697 C CD1 . LEU B 1 304 ? 93.650  104.155 110.614 1.00 24.11  ? 304 LEU B CD1 1 
ATOM 6698 C CD2 . LEU B 1 304 ? 91.406  105.142 110.981 1.00 17.27  ? 304 LEU B CD2 1 
ATOM 6699 N N   . ILE B 1 305 ? 96.256  105.957 111.893 1.00 8.54   ? 305 ILE B N   1 
ATOM 6700 C CA  . ILE B 1 305 ? 97.022  106.964 111.173 1.00 15.70  ? 305 ILE B CA  1 
ATOM 6701 C C   . ILE B 1 305 ? 96.707  106.793 109.696 1.00 14.93  ? 305 ILE B C   1 
ATOM 6702 O O   . ILE B 1 305 ? 96.970  105.733 109.115 1.00 25.16  ? 305 ILE B O   1 
ATOM 6703 C CB  . ILE B 1 305 ? 98.529  106.845 111.433 1.00 8.84   ? 305 ILE B CB  1 
ATOM 6704 C CG1 . ILE B 1 305 ? 98.854  107.212 112.883 1.00 1.00   ? 305 ILE B CG1 1 
ATOM 6705 C CG2 . ILE B 1 305 ? 99.302  107.707 110.443 1.00 24.48  ? 305 ILE B CG2 1 
ATOM 6706 C CD1 . ILE B 1 305 ? 100.314 107.531 113.120 1.00 14.20  ? 305 ILE B CD1 1 
ATOM 6707 N N   . SER B 1 306 ? 96.138  107.827 109.089 1.00 24.54  ? 306 SER B N   1 
ATOM 6708 C CA  . SER B 1 306 ? 95.841  107.830 107.667 1.00 26.40  ? 306 SER B CA  1 
ATOM 6709 C C   . SER B 1 306 ? 96.208  109.184 107.086 1.00 37.92  ? 306 SER B C   1 
ATOM 6710 O O   . SER B 1 306 ? 96.258  110.190 107.798 1.00 37.86  ? 306 SER B O   1 
ATOM 6711 C CB  . SER B 1 306 ? 94.366  107.522 107.394 1.00 41.29  ? 306 SER B CB  1 
ATOM 6712 O OG  . SER B 1 306 ? 93.893  106.510 108.265 1.00 51.69  ? 306 SER B OG  1 
ATOM 6713 N N   . TYR B 1 307 ? 96.476  109.199 105.782 1.00 47.26  ? 307 TYR B N   1 
ATOM 6714 C CA  . TYR B 1 307 ? 96.877  110.441 105.133 1.00 50.31  ? 307 TYR B CA  1 
ATOM 6715 C C   . TYR B 1 307 ? 95.694  111.387 104.976 1.00 63.50  ? 307 TYR B C   1 
ATOM 6716 O O   . TYR B 1 307 ? 95.821  112.596 105.194 1.00 65.01  ? 307 TYR B O   1 
ATOM 6717 C CB  . TYR B 1 307 ? 97.512  110.144 103.776 1.00 46.12  ? 307 TYR B CB  1 
ATOM 6718 C CG  . TYR B 1 307 ? 98.457  111.223 103.313 1.00 49.61  ? 307 TYR B CG  1 
ATOM 6719 C CD1 . TYR B 1 307 ? 99.110  112.036 104.229 1.00 52.32  ? 307 TYR B CD1 1 
ATOM 6720 C CD2 . TYR B 1 307 ? 98.693  111.432 101.963 1.00 52.86  ? 307 TYR B CD2 1 
ATOM 6721 C CE1 . TYR B 1 307 ? 99.975  113.026 103.815 1.00 57.36  ? 307 TYR B CE1 1 
ATOM 6722 C CE2 . TYR B 1 307 ? 99.554  112.420 101.538 1.00 54.94  ? 307 TYR B CE2 1 
ATOM 6723 C CZ  . TYR B 1 307 ? 100.193 113.214 102.468 1.00 55.64  ? 307 TYR B CZ  1 
ATOM 6724 O OH  . TYR B 1 307 ? 101.056 114.200 102.049 1.00 51.35  ? 307 TYR B OH  1 
ATOM 6725 N N   . ASP B 1 308 ? 94.534  110.853 104.600 1.00 74.54  ? 308 ASP B N   1 
ATOM 6726 C CA  . ASP B 1 308 ? 93.349  111.656 104.342 1.00 70.69  ? 308 ASP B CA  1 
ATOM 6727 C C   . ASP B 1 308 ? 92.138  110.979 104.967 1.00 67.49  ? 308 ASP B C   1 
ATOM 6728 O O   . ASP B 1 308 ? 92.183  109.810 105.358 1.00 64.92  ? 308 ASP B O   1 
ATOM 6729 C CB  . ASP B 1 308 ? 93.114  111.854 102.838 1.00 65.61  ? 308 ASP B CB  1 
ATOM 6730 C CG  . ASP B 1 308 ? 94.333  112.395 102.120 1.00 71.64  ? 308 ASP B CG  1 
ATOM 6731 O OD1 . ASP B 1 308 ? 94.861  113.444 102.543 1.00 71.48  ? 308 ASP B OD1 1 
ATOM 6732 O OD2 . ASP B 1 308 ? 94.763  111.769 101.129 1.00 68.87  ? 308 ASP B OD2 1 
ATOM 6733 N N   . LEU B 1 309 ? 91.049  111.735 105.069 1.00 66.33  ? 309 LEU B N   1 
ATOM 6734 C CA  . LEU B 1 309 ? 89.768  111.146 105.430 1.00 70.48  ? 309 LEU B CA  1 
ATOM 6735 C C   . LEU B 1 309 ? 89.243  110.331 104.254 1.00 68.05  ? 309 LEU B C   1 
ATOM 6736 O O   . LEU B 1 309 ? 89.149  110.837 103.131 1.00 70.20  ? 309 LEU B O   1 
ATOM 6737 C CB  . LEU B 1 309 ? 88.771  112.239 105.818 1.00 70.12  ? 309 LEU B CB  1 
ATOM 6738 C CG  . LEU B 1 309 ? 88.975  112.951 107.159 1.00 72.11  ? 309 LEU B CG  1 
ATOM 6739 C CD1 . LEU B 1 309 ? 87.996  114.104 107.298 1.00 70.98  ? 309 LEU B CD1 1 
ATOM 6740 C CD2 . LEU B 1 309 ? 88.822  111.989 108.323 1.00 70.48  ? 309 LEU B CD2 1 
ATOM 6741 N N   . ARG B 1 310 ? 88.900  109.069 104.511 1.00 67.84  ? 310 ARG B N   1 
ATOM 6742 C CA  . ARG B 1 310 ? 88.503  108.133 103.471 1.00 60.45  ? 310 ARG B CA  1 
ATOM 6743 C C   . ARG B 1 310 ? 86.993  107.913 103.520 1.00 65.30  ? 310 ARG B C   1 
ATOM 6744 O O   . ARG B 1 310 ? 86.298  108.411 104.413 1.00 68.59  ? 310 ARG B O   1 
ATOM 6745 C CB  . ARG B 1 310 ? 89.275  106.822 103.624 1.00 63.59  ? 310 ARG B CB  1 
ATOM 6746 C CG  . ARG B 1 310 ? 90.779  107.006 103.647 1.00 66.37  ? 310 ARG B CG  1 
ATOM 6747 C CD  . ARG B 1 310 ? 91.461  106.282 102.507 1.00 65.69  ? 310 ARG B CD  1 
ATOM 6748 N NE  . ARG B 1 310 ? 92.905  106.467 102.563 1.00 61.63  ? 310 ARG B NE  1 
ATOM 6749 C CZ  . ARG B 1 310 ? 93.699  106.495 101.503 1.00 67.55  ? 310 ARG B CZ  1 
ATOM 6750 N NH1 . ARG B 1 310 ? 93.222  106.360 100.277 1.00 65.73  ? 310 ARG B NH1 1 
ATOM 6751 N NH2 . ARG B 1 310 ? 95.006  106.661 101.678 1.00 74.84  ? 310 ARG B NH2 1 
ATOM 6752 N N   . GLU B 1 311 ? 86.486  107.152 102.552 1.00 74.47  ? 311 GLU B N   1 
ATOM 6753 C CA  . GLU B 1 311 ? 85.047  106.997 102.383 1.00 79.10  ? 311 GLU B CA  1 
ATOM 6754 C C   . GLU B 1 311 ? 84.454  106.153 103.503 1.00 77.72  ? 311 GLU B C   1 
ATOM 6755 O O   . GLU B 1 311 ? 84.957  105.070 103.814 1.00 75.52  ? 311 GLU B O   1 
ATOM 6756 C CB  . GLU B 1 311 ? 84.746  106.365 101.024 1.00 76.52  ? 311 GLU B CB  1 
ATOM 6757 C CG  . GLU B 1 311 ? 83.343  105.803 100.883 1.00 75.96  ? 311 GLU B CG  1 
ATOM 6758 C CD  . GLU B 1 311 ? 82.276  106.861 101.064 1.00 76.11  ? 311 GLU B CD  1 
ATOM 6759 O OE1 . GLU B 1 311 ? 82.439  107.968 100.512 1.00 80.17  ? 311 GLU B OE1 1 
ATOM 6760 O OE2 . GLU B 1 311 ? 81.276  106.588 101.759 1.00 71.59  ? 311 GLU B OE2 1 
ATOM 6761 N N   . GLY B 1 312 ? 83.381  106.656 104.108 1.00 75.39  ? 312 GLY B N   1 
ATOM 6762 C CA  . GLY B 1 312 ? 82.700  105.928 105.163 1.00 77.39  ? 312 GLY B CA  1 
ATOM 6763 C C   . GLY B 1 312 ? 83.488  105.819 106.446 1.00 75.12  ? 312 GLY B C   1 
ATOM 6764 O O   . GLY B 1 312 ? 83.217  104.927 107.256 1.00 75.35  ? 312 GLY B O   1 
ATOM 6765 N N   . GLN B 1 313 ? 84.458  106.710 106.661 1.00 68.74  ? 313 GLN B N   1 
ATOM 6766 C CA  . GLN B 1 313 ? 85.300  106.638 107.843 1.00 65.11  ? 313 GLN B CA  1 
ATOM 6767 C C   . GLN B 1 313 ? 85.031  107.754 108.843 1.00 77.24  ? 313 GLN B C   1 
ATOM 6768 O O   . GLN B 1 313 ? 85.019  107.478 110.047 1.00 77.83  ? 313 GLN B O   1 
ATOM 6769 C CB  . GLN B 1 313 ? 86.789  106.654 107.448 1.00 64.76  ? 313 GLN B CB  1 
ATOM 6770 C CG  . GLN B 1 313 ? 87.714  107.420 108.391 1.00 64.43  ? 313 GLN B CG  1 
ATOM 6771 C CD  . GLN B 1 313 ? 89.099  107.649 107.827 1.00 73.89  ? 313 GLN B CD  1 
ATOM 6772 O OE1 . GLN B 1 313 ? 89.267  107.852 106.633 1.00 80.14  ? 313 GLN B OE1 1 
ATOM 6773 N NE2 . GLN B 1 313 ? 90.104  107.584 108.687 1.00 67.01  ? 313 GLN B NE2 1 
ATOM 6774 N N   . ASP B 1 314 ? 84.760  108.982 108.395 1.00 85.39  ? 314 ASP B N   1 
ATOM 6775 C CA  . ASP B 1 314 ? 84.552  110.113 109.290 1.00 77.35  ? 314 ASP B CA  1 
ATOM 6776 C C   . ASP B 1 314 ? 83.104  110.237 109.754 1.00 77.47  ? 314 ASP B C   1 
ATOM 6777 O O   . ASP B 1 314 ? 82.674  111.331 110.134 1.00 78.87  ? 314 ASP B O   1 
ATOM 6778 C CB  . ASP B 1 314 ? 84.999  111.413 108.617 1.00 77.21  ? 314 ASP B CB  1 
ATOM 6779 C CG  . ASP B 1 314 ? 84.624  111.472 107.147 1.00 80.05  ? 314 ASP B CG  1 
ATOM 6780 O OD1 . ASP B 1 314 ? 83.428  111.306 106.827 1.00 80.15  ? 314 ASP B OD1 1 
ATOM 6781 O OD2 . ASP B 1 314 ? 85.523  111.697 106.310 1.00 77.78  ? 314 ASP B OD2 1 
ATOM 6782 N N   . SER B 1 315 ? 82.349  109.143 109.737 1.00 72.91  ? 315 SER B N   1 
ATOM 6783 C CA  . SER B 1 315 ? 80.946  109.168 110.124 1.00 73.51  ? 315 SER B CA  1 
ATOM 6784 C C   . SER B 1 315 ? 80.828  109.058 111.644 1.00 77.02  ? 315 SER B C   1 
ATOM 6785 O O   . SER B 1 315 ? 81.811  109.177 112.381 1.00 75.03  ? 315 SER B O   1 
ATOM 6786 C CB  . SER B 1 315 ? 80.183  108.058 109.408 1.00 75.48  ? 315 SER B CB  1 
ATOM 6787 O OG  . SER B 1 315 ? 78.952  107.791 110.053 1.00 78.21  ? 315 SER B OG  1 
ATOM 6788 N N   . GLU B 1 316 ? 79.605  108.834 112.131 1.00 81.20  ? 316 GLU B N   1 
ATOM 6789 C CA  . GLU B 1 316 ? 79.364  108.764 113.568 1.00 83.72  ? 316 GLU B CA  1 
ATOM 6790 C C   . GLU B 1 316 ? 79.930  107.497 114.197 1.00 83.76  ? 316 GLU B C   1 
ATOM 6791 O O   . GLU B 1 316 ? 80.279  107.516 115.385 1.00 80.77  ? 316 GLU B O   1 
ATOM 6792 C CB  . GLU B 1 316 ? 77.864  108.860 113.853 1.00 83.11  ? 316 GLU B CB  1 
ATOM 6793 C CG  . GLU B 1 316 ? 77.524  109.297 115.271 1.00 86.11  ? 316 GLU B CG  1 
ATOM 6794 C CD  . GLU B 1 316 ? 77.172  108.130 116.173 1.00 81.81  ? 316 GLU B CD  1 
ATOM 6795 O OE1 . GLU B 1 316 ? 76.780  107.067 115.647 1.00 81.82  ? 316 GLU B OE1 1 
ATOM 6796 O OE2 . GLU B 1 316 ? 77.287  108.275 117.408 1.00 88.85  ? 316 GLU B OE2 1 
ATOM 6797 N N   . GLU B 1 317 ? 80.036  106.408 113.425 1.00 82.36  ? 317 GLU B N   1 
ATOM 6798 C CA  . GLU B 1 317 ? 80.480  105.130 113.975 1.00 75.77  ? 317 GLU B CA  1 
ATOM 6799 C C   . GLU B 1 317 ? 81.918  105.199 114.472 1.00 72.49  ? 317 GLU B C   1 
ATOM 6800 O O   . GLU B 1 317 ? 82.225  104.703 115.562 1.00 75.82  ? 317 GLU B O   1 
ATOM 6801 C CB  . GLU B 1 317 ? 80.328  104.025 112.928 1.00 76.14  ? 317 GLU B CB  1 
ATOM 6802 C CG  . GLU B 1 317 ? 80.711  104.436 111.515 1.00 76.05  ? 317 GLU B CG  1 
ATOM 6803 C CD  . GLU B 1 317 ? 79.508  104.782 110.661 1.00 76.32  ? 317 GLU B CD  1 
ATOM 6804 O OE1 . GLU B 1 317 ? 78.498  105.259 111.219 1.00 75.82  ? 317 GLU B OE1 1 
ATOM 6805 O OE2 . GLU B 1 317 ? 79.574  104.582 109.431 1.00 77.99  ? 317 GLU B OE2 1 
ATOM 6806 N N   . LEU B 1 318 ? 82.814  105.814 113.698 1.00 61.63  ? 318 LEU B N   1 
ATOM 6807 C CA  . LEU B 1 318 ? 84.179  105.988 114.174 1.00 72.71  ? 318 LEU B CA  1 
ATOM 6808 C C   . LEU B 1 318 ? 84.291  107.120 115.187 1.00 73.77  ? 318 LEU B C   1 
ATOM 6809 O O   . LEU B 1 318 ? 85.086  107.024 116.129 1.00 74.77  ? 318 LEU B O   1 
ATOM 6810 C CB  . LEU B 1 318 ? 85.128  106.233 113.002 1.00 71.38  ? 318 LEU B CB  1 
ATOM 6811 C CG  . LEU B 1 318 ? 86.621  106.255 113.341 1.00 60.73  ? 318 LEU B CG  1 
ATOM 6812 C CD1 . LEU B 1 318 ? 87.132  104.857 113.621 1.00 65.57  ? 318 LEU B CD1 1 
ATOM 6813 C CD2 . LEU B 1 318 ? 87.426  106.907 112.233 1.00 61.65  ? 318 LEU B CD2 1 
ATOM 6814 N N   . SER B 1 319 ? 83.505  108.188 115.025 1.00 68.67  ? 319 SER B N   1 
ATOM 6815 C CA  . SER B 1 319 ? 83.612  109.327 115.929 1.00 71.22  ? 319 SER B CA  1 
ATOM 6816 C C   . SER B 1 319 ? 83.035  109.045 117.310 1.00 71.64  ? 319 SER B C   1 
ATOM 6817 O O   . SER B 1 319 ? 83.277  109.832 118.231 1.00 71.89  ? 319 SER B O   1 
ATOM 6818 C CB  . SER B 1 319 ? 82.920  110.550 115.329 1.00 73.52  ? 319 SER B CB  1 
ATOM 6819 O OG  . SER B 1 319 ? 81.514  110.417 115.383 1.00 75.28  ? 319 SER B OG  1 
ATOM 6820 N N   . SER B 1 320 ? 82.285  107.956 117.480 1.00 72.68  ? 320 SER B N   1 
ATOM 6821 C CA  . SER B 1 320 ? 81.764  107.569 118.783 1.00 72.47  ? 320 SER B CA  1 
ATOM 6822 C C   . SER B 1 320 ? 82.717  106.661 119.559 1.00 70.32  ? 320 SER B C   1 
ATOM 6823 O O   . SER B 1 320 ? 82.272  105.948 120.465 1.00 74.14  ? 320 SER B O   1 
ATOM 6824 C CB  . SER B 1 320 ? 80.407  106.882 118.624 1.00 70.25  ? 320 SER B CB  1 
ATOM 6825 O OG  . SER B 1 320 ? 80.480  105.824 117.685 1.00 69.84  ? 320 SER B OG  1 
ATOM 6826 N N   . LEU B 1 321 ? 84.013  106.668 119.228 1.00 65.35  ? 321 LEU B N   1 
ATOM 6827 C CA  . LEU B 1 321 ? 84.967  105.765 119.861 1.00 61.77  ? 321 LEU B CA  1 
ATOM 6828 C C   . LEU B 1 321 ? 86.215  106.458 120.398 1.00 63.27  ? 321 LEU B C   1 
ATOM 6829 O O   . LEU B 1 321 ? 87.120  105.770 120.882 1.00 67.79  ? 321 LEU B O   1 
ATOM 6830 C CB  . LEU B 1 321 ? 85.396  104.658 118.891 1.00 63.79  ? 321 LEU B CB  1 
ATOM 6831 C CG  . LEU B 1 321 ? 84.328  103.828 118.181 1.00 64.74  ? 321 LEU B CG  1 
ATOM 6832 C CD1 . LEU B 1 321 ? 84.887  103.262 116.893 1.00 62.81  ? 321 LEU B CD1 1 
ATOM 6833 C CD2 . LEU B 1 321 ? 83.837  102.711 119.084 1.00 62.39  ? 321 LEU B CD2 1 
ATOM 6834 N N   . ILE B 1 322 ? 86.303  107.785 120.329 1.00 65.14  ? 322 ILE B N   1 
ATOM 6835 C CA  . ILE B 1 322 ? 87.504  108.465 120.802 1.00 68.83  ? 322 ILE B CA  1 
ATOM 6836 C C   . ILE B 1 322 ? 87.518  108.467 122.323 1.00 75.55  ? 322 ILE B C   1 
ATOM 6837 O O   . ILE B 1 322 ? 86.540  108.865 122.969 1.00 72.08  ? 322 ILE B O   1 
ATOM 6838 C CB  . ILE B 1 322 ? 87.574  109.895 120.249 1.00 74.58  ? 322 ILE B CB  1 
ATOM 6839 C CG1 . ILE B 1 322 ? 87.556  109.881 118.723 1.00 69.20  ? 322 ILE B CG1 1 
ATOM 6840 C CG2 . ILE B 1 322 ? 88.829  110.596 120.745 1.00 75.13  ? 322 ILE B CG2 1 
ATOM 6841 C CD1 . ILE B 1 322 ? 86.718  110.988 118.122 1.00 78.51  ? 322 ILE B CD1 1 
ATOM 6842 N N   . LYS B 1 323 ? 88.628  108.021 122.904 1.00 86.30  ? 323 LYS B N   1 
ATOM 6843 C CA  . LYS B 1 323 ? 88.756  107.984 124.353 1.00 88.73  ? 323 LYS B CA  1 
ATOM 6844 C C   . LYS B 1 323 ? 89.170  109.348 124.888 1.00 90.39  ? 323 LYS B C   1 
ATOM 6845 O O   . LYS B 1 323 ? 90.079  109.993 124.356 1.00 87.05  ? 323 LYS B O   1 
ATOM 6846 C CB  . LYS B 1 323 ? 89.773  106.926 124.778 1.00 85.38  ? 323 LYS B CB  1 
ATOM 6847 C CG  . LYS B 1 323 ? 89.689  106.555 126.249 1.00 85.23  ? 323 LYS B CG  1 
ATOM 6848 C CD  . LYS B 1 323 ? 88.287  106.101 126.618 1.00 84.77  ? 323 LYS B CD  1 
ATOM 6849 C CE  . LYS B 1 323 ? 88.141  105.918 128.118 1.00 86.37  ? 323 LYS B CE  1 
ATOM 6850 N NZ  . LYS B 1 323 ? 89.298  105.185 128.701 1.00 88.87  ? 323 LYS B NZ  1 
ATOM 6851 N N   . SER B 1 324 ? 88.497  109.783 125.949 1.00 100.88 ? 324 SER B N   1 
ATOM 6852 C CA  . SER B 1 324 ? 88.774  111.078 126.560 1.00 97.21  ? 324 SER B CA  1 
ATOM 6853 C C   . SER B 1 324 ? 90.084  111.049 127.339 1.00 98.81  ? 324 SER B C   1 
ATOM 6854 O O   . SER B 1 324 ? 90.871  111.994 127.284 1.00 98.08  ? 324 SER B O   1 
ATOM 6855 C CB  . SER B 1 324 ? 87.624  111.491 127.479 1.00 96.02  ? 324 SER B CB  1 
ATOM 6856 O OG  . SER B 1 324 ? 86.371  111.163 126.905 1.00 95.78  ? 324 SER B OG  1 
ATOM 6857 N N   . GLN B 1 337 ? 86.652  117.094 101.355 1.00 69.11  ? 337 GLN B N   1 
ATOM 6858 C CA  . GLN B 1 337 ? 86.270  115.942 100.548 1.00 71.89  ? 337 GLN B CA  1 
ATOM 6859 C C   . GLN B 1 337 ? 86.647  114.641 101.249 1.00 72.85  ? 337 GLN B C   1 
ATOM 6860 O O   . GLN B 1 337 ? 87.081  114.654 102.400 1.00 72.79  ? 337 GLN B O   1 
ATOM 6861 C CB  . GLN B 1 337 ? 86.925  116.016 99.168  1.00 70.57  ? 337 GLN B CB  1 
ATOM 6862 C CG  . GLN B 1 337 ? 88.404  116.357 99.202  1.00 72.83  ? 337 GLN B CG  1 
ATOM 6863 C CD  . GLN B 1 337 ? 88.959  116.664 97.826  1.00 74.95  ? 337 GLN B CD  1 
ATOM 6864 O OE1 . GLN B 1 337 ? 88.253  116.563 96.823  1.00 74.79  ? 337 GLN B OE1 1 
ATOM 6865 N NE2 . GLN B 1 337 ? 90.230  117.044 97.771  1.00 76.30  ? 337 GLN B NE2 1 
ATOM 6866 N N   . GLN B 1 338 ? 86.472  113.516 100.557 1.00 75.63  ? 338 GLN B N   1 
ATOM 6867 C CA  . GLN B 1 338 ? 86.766  112.212 101.131 1.00 75.28  ? 338 GLN B CA  1 
ATOM 6868 C C   . GLN B 1 338 ? 87.527  111.355 100.133 1.00 75.37  ? 338 GLN B C   1 
ATOM 6869 O O   . GLN B 1 338 ? 87.206  111.337 98.941  1.00 72.38  ? 338 GLN B O   1 
ATOM 6870 C CB  . GLN B 1 338 ? 85.486  111.484 101.564 1.00 74.86  ? 338 GLN B CB  1 
ATOM 6871 C CG  . GLN B 1 338 ? 85.019  111.829 102.968 1.00 76.65  ? 338 GLN B CG  1 
ATOM 6872 C CD  . GLN B 1 338 ? 83.775  111.064 103.369 1.00 76.16  ? 338 GLN B CD  1 
ATOM 6873 O OE1 . GLN B 1 338 ? 83.477  110.006 102.815 1.00 74.81  ? 338 GLN B OE1 1 
ATOM 6874 N NE2 . GLN B 1 338 ? 83.040  111.594 104.338 1.00 75.46  ? 338 GLN B NE2 1 
ATOM 6875 N N   . ALA B 1 339 ? 88.540  110.651 100.633 1.00 76.69  ? 339 ALA B N   1 
ATOM 6876 C CA  . ALA B 1 339 ? 89.252  109.669 99.836  1.00 80.12  ? 339 ALA B CA  1 
ATOM 6877 C C   . ALA B 1 339 ? 88.341  108.467 99.566  1.00 76.99  ? 339 ALA B C   1 
ATOM 6878 O O   . ALA B 1 339 ? 87.485  108.137 100.389 1.00 77.55  ? 339 ALA B O   1 
ATOM 6879 C CB  . ALA B 1 339 ? 90.527  109.243 100.564 1.00 76.59  ? 339 ALA B CB  1 
ATOM 6880 N N   . PRO B 1 340 ? 88.491  107.792 98.408  1.00 82.75  ? 340 PRO B N   1 
ATOM 6881 C CA  . PRO B 1 340 ? 87.468  106.819 98.012  1.00 78.05  ? 340 PRO B CA  1 
ATOM 6882 C C   . PRO B 1 340 ? 87.581  105.493 98.740  1.00 79.83  ? 340 PRO B C   1 
ATOM 6883 O O   . PRO B 1 340 ? 88.326  105.377 99.718  1.00 82.21  ? 340 PRO B O   1 
ATOM 6884 C CB  . PRO B 1 340 ? 87.708  106.673 96.502  1.00 79.14  ? 340 PRO B CB  1 
ATOM 6885 C CG  . PRO B 1 340 ? 89.126  107.253 96.261  1.00 81.27  ? 340 PRO B CG  1 
ATOM 6886 C CD  . PRO B 1 340 ? 89.702  107.532 97.614  1.00 77.53  ? 340 PRO B CD  1 
ATOM 6887 N N   . ARG B 1 341 ? 86.798  104.509 98.293  1.00 77.69  ? 341 ARG B N   1 
ATOM 6888 C CA  . ARG B 1 341 ? 86.773  103.198 98.930  1.00 70.21  ? 341 ARG B CA  1 
ATOM 6889 C C   . ARG B 1 341 ? 88.147  102.542 98.868  1.00 69.84  ? 341 ARG B C   1 
ATOM 6890 O O   . ARG B 1 341 ? 88.649  102.221 97.787  1.00 69.62  ? 341 ARG B O   1 
ATOM 6891 C CB  . ARG B 1 341 ? 85.729  102.307 98.255  1.00 70.36  ? 341 ARG B CB  1 
ATOM 6892 C CG  . ARG B 1 341 ? 85.335  101.095 99.073  1.00 73.14  ? 341 ARG B CG  1 
ATOM 6893 C CD  . ARG B 1 341 ? 84.660  101.521 100.364 1.00 74.77  ? 341 ARG B CD  1 
ATOM 6894 N NE  . ARG B 1 341 ? 85.553  101.389 101.508 1.00 78.14  ? 341 ARG B NE  1 
ATOM 6895 C CZ  . ARG B 1 341 ? 85.217  101.672 102.758 1.00 72.87  ? 341 ARG B CZ  1 
ATOM 6896 N NH1 . ARG B 1 341 ? 84.003  102.096 103.068 1.00 68.56  ? 341 ARG B NH1 1 
ATOM 6897 N NH2 . ARG B 1 341 ? 86.123  101.530 103.721 1.00 69.09  ? 341 ARG B NH2 1 
ATOM 6898 N N   . SER B 1 342 ? 88.752  102.356 100.039 1.00 54.25  ? 342 SER B N   1 
ATOM 6899 C CA  . SER B 1 342 ? 90.136  101.913 100.125 1.00 51.17  ? 342 SER B CA  1 
ATOM 6900 C C   . SER B 1 342 ? 90.277  100.460 99.688  1.00 53.15  ? 342 SER B C   1 
ATOM 6901 O O   . SER B 1 342 ? 89.329  99.674  99.744  1.00 51.82  ? 342 SER B O   1 
ATOM 6902 C CB  . SER B 1 342 ? 90.656  102.083 101.550 1.00 47.51  ? 342 SER B CB  1 
ATOM 6903 O OG  . SER B 1 342 ? 92.026  101.742 101.637 1.00 48.17  ? 342 SER B OG  1 
ATOM 6904 N N   . ARG B 1 343 ? 91.482  100.110 99.238  1.00 45.46  ? 343 ARG B N   1 
ATOM 6905 C CA  . ARG B 1 343 ? 91.723  98.762  98.736  1.00 37.49  ? 343 ARG B CA  1 
ATOM 6906 C C   . ARG B 1 343 ? 92.167  97.823  99.852  1.00 37.81  ? 343 ARG B C   1 
ATOM 6907 O O   . ARG B 1 343 ? 91.641  96.713  99.986  1.00 47.20  ? 343 ARG B O   1 
ATOM 6908 C CB  . ARG B 1 343 ? 92.762  98.798  97.613  1.00 38.47  ? 343 ARG B CB  1 
ATOM 6909 C CG  . ARG B 1 343 ? 92.974  97.467  96.897  1.00 41.46  ? 343 ARG B CG  1 
ATOM 6910 C CD  . ARG B 1 343 ? 91.667  96.730  96.623  1.00 49.38  ? 343 ARG B CD  1 
ATOM 6911 N NE  . ARG B 1 343 ? 90.801  97.446  95.696  1.00 52.27  ? 343 ARG B NE  1 
ATOM 6912 C CZ  . ARG B 1 343 ? 90.558  97.058  94.452  1.00 49.88  ? 343 ARG B CZ  1 
ATOM 6913 N NH1 . ARG B 1 343 ? 91.106  95.963  93.951  1.00 43.14  ? 343 ARG B NH1 1 
ATOM 6914 N NH2 . ARG B 1 343 ? 89.746  97.785  93.692  1.00 45.43  ? 343 ARG B NH2 1 
ATOM 6915 N N   . SER B 1 344 ? 93.137  98.243  100.658 1.00 31.44  ? 344 SER B N   1 
ATOM 6916 C CA  . SER B 1 344 ? 93.641  97.379  101.715 1.00 30.41  ? 344 SER B CA  1 
ATOM 6917 C C   . SER B 1 344 ? 94.186  98.231  102.849 1.00 26.55  ? 344 SER B C   1 
ATOM 6918 O O   . SER B 1 344 ? 94.582  99.382  102.657 1.00 42.51  ? 344 SER B O   1 
ATOM 6919 C CB  . SER B 1 344 ? 94.725  96.438  101.199 1.00 31.79  ? 344 SER B CB  1 
ATOM 6920 O OG  . SER B 1 344 ? 95.679  96.187  102.214 1.00 30.91  ? 344 SER B OG  1 
ATOM 6921 N N   . LEU B 1 345 ? 94.213  97.637  104.034 1.00 9.28   ? 345 LEU B N   1 
ATOM 6922 C CA  . LEU B 1 345 ? 94.770  98.264  105.221 1.00 10.02  ? 345 LEU B CA  1 
ATOM 6923 C C   . LEU B 1 345 ? 96.131  97.667  105.537 1.00 1.00   ? 345 LEU B C   1 
ATOM 6924 O O   . LEU B 1 345 ? 96.537  96.648  104.980 1.00 22.65  ? 345 LEU B O   1 
ATOM 6925 C CB  . LEU B 1 345 ? 93.831  98.107  106.423 1.00 25.97  ? 345 LEU B CB  1 
ATOM 6926 C CG  . LEU B 1 345 ? 93.703  96.742  107.102 1.00 22.52  ? 345 LEU B CG  1 
ATOM 6927 C CD1 . LEU B 1 345 ? 93.242  96.919  108.528 1.00 18.62  ? 345 LEU B CD1 1 
ATOM 6928 C CD2 . LEU B 1 345 ? 92.708  95.858  106.368 1.00 24.16  ? 345 LEU B CD2 1 
ATOM 6929 N N   . ILE B 1 346 ? 96.843  98.327  106.444 1.00 5.78   ? 346 ILE B N   1 
ATOM 6930 C CA  . ILE B 1 346 ? 98.132  97.855  106.931 1.00 20.41  ? 346 ILE B CA  1 
ATOM 6931 C C   . ILE B 1 346 ? 98.078  97.862  108.450 1.00 19.33  ? 346 ILE B C   1 
ATOM 6932 O O   . ILE B 1 346 ? 97.813  98.903  109.061 1.00 32.53  ? 346 ILE B O   1 
ATOM 6933 C CB  . ILE B 1 346 ? 99.302  98.712  106.415 1.00 22.89  ? 346 ILE B CB  1 
ATOM 6934 C CG1 . ILE B 1 346 ? 99.641  98.323  104.975 1.00 17.52  ? 346 ILE B CG1 1 
ATOM 6935 C CG2 . ILE B 1 346 ? 100.531 98.560  107.300 1.00 20.58  ? 346 ILE B CG2 1 
ATOM 6936 C CD1 . ILE B 1 346 ? 100.819 99.062  104.396 1.00 22.98  ? 346 ILE B CD1 1 
ATOM 6937 N N   . VAL B 1 347 ? 98.303  96.711  109.048 1.00 17.00  ? 347 VAL B N   1 
ATOM 6938 C CA  . VAL B 1 347 ? 98.351  96.563  110.493 1.00 9.09   ? 347 VAL B CA  1 
ATOM 6939 C C   . VAL B 1 347 ? 99.769  96.884  110.934 1.00 5.76   ? 347 VAL B C   1 
ATOM 6940 O O   . VAL B 1 347 ? 100.718 96.771  110.153 1.00 29.50  ? 347 VAL B O   1 
ATOM 6941 C CB  . VAL B 1 347 ? 97.917  95.136  110.894 1.00 10.73  ? 347 VAL B CB  1 
ATOM 6942 C CG1 . VAL B 1 347 ? 97.671  95.021  112.373 1.00 15.22  ? 347 VAL B CG1 1 
ATOM 6943 C CG2 . VAL B 1 347 ? 96.665  94.751  110.149 1.00 3.07   ? 347 VAL B CG2 1 
ATOM 6944 N N   . HIS B 1 348 ? 99.922  97.331  112.176 1.00 1.00   ? 348 HIS B N   1 
ATOM 6945 C CA  . HIS B 1 348 ? 101.241 97.609  112.720 1.00 1.00   ? 348 HIS B CA  1 
ATOM 6946 C C   . HIS B 1 348 ? 101.231 97.326  114.212 1.00 1.00   ? 348 HIS B C   1 
ATOM 6947 O O   . HIS B 1 348 ? 100.324 97.765  114.923 1.00 18.09  ? 348 HIS B O   1 
ATOM 6948 C CB  . HIS B 1 348 ? 101.650 99.060  112.450 1.00 7.57   ? 348 HIS B CB  1 
ATOM 6949 C CG  . HIS B 1 348 ? 103.035 99.400  112.907 1.00 16.68  ? 348 HIS B CG  1 
ATOM 6950 N ND1 . HIS B 1 348 ? 103.349 99.636  114.228 1.00 19.33  ? 348 HIS B ND1 1 
ATOM 6951 C CD2 . HIS B 1 348 ? 104.185 99.566  112.213 1.00 21.12  ? 348 HIS B CD2 1 
ATOM 6952 C CE1 . HIS B 1 348 ? 104.635 99.918  114.329 1.00 12.85  ? 348 HIS B CE1 1 
ATOM 6953 N NE2 . HIS B 1 348 ? 105.165 99.884  113.120 1.00 15.08  ? 348 HIS B NE2 1 
ATOM 6954 N N   . PHE B 1 349 ? 102.234 96.589  114.677 1.00 22.20  ? 349 PHE B N   1 
ATOM 6955 C CA  . PHE B 1 349 ? 102.497 96.403  116.096 1.00 18.16  ? 349 PHE B CA  1 
ATOM 6956 C C   . PHE B 1 349 ? 103.794 97.120  116.436 1.00 33.92  ? 349 PHE B C   1 
ATOM 6957 O O   . PHE B 1 349 ? 104.784 96.992  115.709 1.00 24.30  ? 349 PHE B O   1 
ATOM 6958 C CB  . PHE B 1 349 ? 102.611 94.921  116.459 1.00 18.49  ? 349 PHE B CB  1 
ATOM 6959 C CG  . PHE B 1 349 ? 101.408 94.104  116.088 1.00 16.72  ? 349 PHE B CG  1 
ATOM 6960 C CD1 . PHE B 1 349 ? 100.224 94.237  116.782 1.00 17.16  ? 349 PHE B CD1 1 
ATOM 6961 C CD2 . PHE B 1 349 ? 101.470 93.182  115.059 1.00 27.68  ? 349 PHE B CD2 1 
ATOM 6962 C CE1 . PHE B 1 349 ? 99.120  93.482  116.440 1.00 18.64  ? 349 PHE B CE1 1 
ATOM 6963 C CE2 . PHE B 1 349 ? 100.365 92.420  114.724 1.00 24.97  ? 349 PHE B CE2 1 
ATOM 6964 C CZ  . PHE B 1 349 ? 99.193  92.572  115.414 1.00 15.47  ? 349 PHE B CZ  1 
ATOM 6965 N N   . HIS B 1 350 ? 103.793 97.871  117.532 1.00 29.11  ? 350 HIS B N   1 
ATOM 6966 C CA  . HIS B 1 350 ? 105.002 98.572  117.925 1.00 27.65  ? 350 HIS B CA  1 
ATOM 6967 C C   . HIS B 1 350 ? 106.010 97.597  118.533 1.00 28.12  ? 350 HIS B C   1 
ATOM 6968 O O   . HIS B 1 350 ? 105.714 96.427  118.787 1.00 31.24  ? 350 HIS B O   1 
ATOM 6969 C CB  . HIS B 1 350 ? 104.680 99.696  118.908 1.00 23.90  ? 350 HIS B CB  1 
ATOM 6970 C CG  . HIS B 1 350 ? 104.075 99.230  120.195 1.00 24.29  ? 350 HIS B CG  1 
ATOM 6971 N ND1 . HIS B 1 350 ? 102.727 99.327  120.459 1.00 33.49  ? 350 HIS B ND1 1 
ATOM 6972 C CD2 . HIS B 1 350 ? 104.634 98.670  121.293 1.00 28.86  ? 350 HIS B CD2 1 
ATOM 6973 C CE1 . HIS B 1 350 ? 102.482 98.849  121.665 1.00 31.93  ? 350 HIS B CE1 1 
ATOM 6974 N NE2 . HIS B 1 350 ? 103.622 98.442  122.192 1.00 32.65  ? 350 HIS B NE2 1 
ATOM 6975 N N   . GLY B 1 351 ? 107.222 98.093  118.763 1.00 33.57  ? 351 GLY B N   1 
ATOM 6976 C CA  . GLY B 1 351 ? 108.252 97.299  119.402 1.00 27.77  ? 351 GLY B CA  1 
ATOM 6977 C C   . GLY B 1 351 ? 108.580 97.790  120.794 1.00 36.19  ? 351 GLY B C   1 
ATOM 6978 O O   . GLY B 1 351 ? 107.679 98.115  121.570 1.00 38.80  ? 351 GLY B O   1 
ATOM 6979 N N   . GLY B 1 352 ? 109.862 97.842  121.130 1.00 44.65  ? 352 GLY B N   1 
ATOM 6980 C CA  . GLY B 1 352 ? 110.264 98.402  122.404 1.00 45.85  ? 352 GLY B CA  1 
ATOM 6981 C C   . GLY B 1 352 ? 110.380 97.411  123.538 1.00 47.84  ? 352 GLY B C   1 
ATOM 6982 O O   . GLY B 1 352 ? 110.063 97.751  124.685 1.00 47.05  ? 352 GLY B O   1 
ATOM 6983 N N   . GLY B 1 353 ? 110.811 96.187  123.247 1.00 56.22  ? 353 GLY B N   1 
ATOM 6984 C CA  . GLY B 1 353 ? 111.134 95.200  124.261 1.00 50.32  ? 353 GLY B CA  1 
ATOM 6985 C C   . GLY B 1 353 ? 109.990 94.759  125.150 1.00 46.39  ? 353 GLY B C   1 
ATOM 6986 O O   . GLY B 1 353 ? 110.225 94.291  126.269 1.00 51.07  ? 353 GLY B O   1 
ATOM 6987 N N   . PHE B 1 354 ? 108.752 94.950  124.686 1.00 38.89  ? 354 PHE B N   1 
ATOM 6988 C CA  . PHE B 1 354 ? 107.507 94.583  125.367 1.00 54.41  ? 354 PHE B CA  1 
ATOM 6989 C C   . PHE B 1 354 ? 107.311 95.313  126.683 1.00 59.80  ? 354 PHE B C   1 
ATOM 6990 O O   . PHE B 1 354 ? 106.374 94.999  127.425 1.00 61.10  ? 354 PHE B O   1 
ATOM 6991 C CB  . PHE B 1 354 ? 107.400 93.074  125.626 1.00 51.85  ? 354 PHE B CB  1 
ATOM 6992 C CG  . PHE B 1 354 ? 106.941 92.282  124.447 1.00 52.21  ? 354 PHE B CG  1 
ATOM 6993 C CD1 . PHE B 1 354 ? 107.205 92.703  123.165 1.00 58.24  ? 354 PHE B CD1 1 
ATOM 6994 C CD2 . PHE B 1 354 ? 106.252 91.105  124.621 1.00 54.74  ? 354 PHE B CD2 1 
ATOM 6995 C CE1 . PHE B 1 354 ? 106.800 91.977  122.086 1.00 60.31  ? 354 PHE B CE1 1 
ATOM 6996 C CE2 . PHE B 1 354 ? 105.837 90.387  123.537 1.00 54.43  ? 354 PHE B CE2 1 
ATOM 6997 C CZ  . PHE B 1 354 ? 106.122 90.815  122.280 1.00 57.64  ? 354 PHE B CZ  1 
ATOM 6998 N N   . VAL B 1 355 ? 108.173 96.276  126.999 1.00 52.91  ? 355 VAL B N   1 
ATOM 6999 C CA  . VAL B 1 355 ? 108.128 96.965  128.282 1.00 53.59  ? 355 VAL B CA  1 
ATOM 7000 C C   . VAL B 1 355 ? 108.032 98.471  128.137 1.00 51.11  ? 355 VAL B C   1 
ATOM 7001 O O   . VAL B 1 355 ? 107.710 99.162  129.120 1.00 51.98  ? 355 VAL B O   1 
ATOM 7002 C CB  . VAL B 1 355 ? 109.361 96.585  129.131 1.00 53.97  ? 355 VAL B CB  1 
ATOM 7003 C CG1 . VAL B 1 355 ? 109.311 95.117  129.527 1.00 53.83  ? 355 VAL B CG1 1 
ATOM 7004 C CG2 . VAL B 1 355 ? 110.641 96.884  128.369 1.00 53.86  ? 355 VAL B CG2 1 
ATOM 7005 N N   . ALA B 1 356 ? 108.284 99.021  126.956 1.00 49.81  ? 356 ALA B N   1 
ATOM 7006 C CA  . ALA B 1 356 ? 108.207 100.453 126.722 1.00 58.29  ? 356 ALA B CA  1 
ATOM 7007 C C   . ALA B 1 356 ? 107.948 100.669 125.238 1.00 53.42  ? 356 ALA B C   1 
ATOM 7008 O O   . ALA B 1 356 ? 107.668 99.723  124.496 1.00 48.49  ? 356 ALA B O   1 
ATOM 7009 C CB  . ALA B 1 356 ? 109.484 101.158 127.181 1.00 58.94  ? 356 ALA B CB  1 
ATOM 7010 N N   . GLN B 1 357 ? 108.052 101.934 124.819 1.00 49.19  ? 357 GLN B N   1 
ATOM 7011 C CA  . GLN B 1 357 ? 107.859 102.373 123.435 1.00 44.68  ? 357 GLN B CA  1 
ATOM 7012 C C   . GLN B 1 357 ? 106.470 101.969 122.932 1.00 50.79  ? 357 GLN B C   1 
ATOM 7013 O O   . GLN B 1 357 ? 106.298 101.097 122.081 1.00 49.92  ? 357 GLN B O   1 
ATOM 7014 C CB  . GLN B 1 357 ? 108.973 101.847 122.521 1.00 44.10  ? 357 GLN B CB  1 
ATOM 7015 C CG  . GLN B 1 357 ? 108.974 102.441 121.121 1.00 44.78  ? 357 GLN B CG  1 
ATOM 7016 C CD  . GLN B 1 357 ? 110.176 102.020 120.313 1.00 55.86  ? 357 GLN B CD  1 
ATOM 7017 O OE1 . GLN B 1 357 ? 110.271 102.319 119.129 1.00 49.74  ? 357 GLN B OE1 1 
ATOM 7018 N NE2 . GLN B 1 357 ? 111.107 101.324 120.950 1.00 57.16  ? 357 GLN B NE2 1 
ATOM 7019 N N   . THR B 1 358 ? 105.469 102.611 123.525 1.00 44.80  ? 358 THR B N   1 
ATOM 7020 C CA  . THR B 1 358 ? 104.091 102.387 123.122 1.00 49.19  ? 358 THR B CA  1 
ATOM 7021 C C   . THR B 1 358 ? 103.815 103.073 121.782 1.00 44.07  ? 358 THR B C   1 
ATOM 7022 O O   . THR B 1 358 ? 104.713 103.597 121.118 1.00 44.87  ? 358 THR B O   1 
ATOM 7023 C CB  . THR B 1 358 ? 103.139 102.881 124.208 1.00 48.61  ? 358 THR B CB  1 
ATOM 7024 O OG1 . THR B 1 358 ? 101.786 102.665 123.796 1.00 43.32  ? 358 THR B OG1 1 
ATOM 7025 C CG2 . THR B 1 358 ? 103.347 104.352 124.459 1.00 47.20  ? 358 THR B CG2 1 
ATOM 7026 N N   . SER B 1 359 ? 102.545 103.067 121.376 1.00 43.76  ? 359 SER B N   1 
ATOM 7027 C CA  . SER B 1 359 ? 102.168 103.582 120.064 1.00 43.21  ? 359 SER B CA  1 
ATOM 7028 C C   . SER B 1 359 ? 102.362 105.086 119.928 1.00 45.17  ? 359 SER B C   1 
ATOM 7029 O O   . SER B 1 359 ? 102.352 105.590 118.800 1.00 44.70  ? 359 SER B O   1 
ATOM 7030 C CB  . SER B 1 359 ? 100.714 103.226 119.762 1.00 40.47  ? 359 SER B CB  1 
ATOM 7031 O OG  . SER B 1 359 ? 100.470 103.253 118.368 1.00 34.77  ? 359 SER B OG  1 
ATOM 7032 N N   . ARG B 1 360 ? 102.547 105.808 121.033 1.00 57.32  ? 360 ARG B N   1 
ATOM 7033 C CA  . ARG B 1 360 ? 102.780 107.245 121.013 1.00 60.66  ? 360 ARG B CA  1 
ATOM 7034 C C   . ARG B 1 360 ? 104.248 107.611 120.799 1.00 60.75  ? 360 ARG B C   1 
ATOM 7035 O O   . ARG B 1 360 ? 104.647 108.735 121.126 1.00 57.68  ? 360 ARG B O   1 
ATOM 7036 C CB  . ARG B 1 360 ? 102.271 107.880 122.308 1.00 53.38  ? 360 ARG B CB  1 
ATOM 7037 C CG  . ARG B 1 360 ? 100.772 108.109 122.357 1.00 52.54  ? 360 ARG B CG  1 
ATOM 7038 C CD  . ARG B 1 360 ? 100.432 109.116 123.441 1.00 57.83  ? 360 ARG B CD  1 
ATOM 7039 N NE  . ARG B 1 360 ? 101.471 110.131 123.571 1.00 55.43  ? 360 ARG B NE  1 
ATOM 7040 C CZ  . ARG B 1 360 ? 101.764 110.765 124.698 1.00 59.27  ? 360 ARG B CZ  1 
ATOM 7041 N NH1 . ARG B 1 360 ? 101.118 110.509 125.823 1.00 58.23  ? 360 ARG B NH1 1 
ATOM 7042 N NH2 . ARG B 1 360 ? 102.733 111.676 124.696 1.00 59.76  ? 360 ARG B NH2 1 
ATOM 7043 N N   . SER B 1 361 ? 105.054 106.696 120.258 1.00 53.61  ? 361 SER B N   1 
ATOM 7044 C CA  . SER B 1 361 ? 106.457 106.968 119.972 1.00 45.99  ? 361 SER B CA  1 
ATOM 7045 C C   . SER B 1 361 ? 106.902 106.516 118.591 1.00 46.37  ? 361 SER B C   1 
ATOM 7046 O O   . SER B 1 361 ? 108.075 106.705 118.259 1.00 42.35  ? 361 SER B O   1 
ATOM 7047 C CB  . SER B 1 361 ? 107.353 106.296 121.019 1.00 44.79  ? 361 SER B CB  1 
ATOM 7048 O OG  . SER B 1 361 ? 106.907 106.589 122.329 1.00 49.87  ? 361 SER B OG  1 
ATOM 7049 N N   . HIS B 1 362 ? 106.029 105.922 117.785 1.00 46.99  ? 362 HIS B N   1 
ATOM 7050 C CA  . HIS B 1 362 ? 106.391 105.410 116.473 1.00 43.66  ? 362 HIS B CA  1 
ATOM 7051 C C   . HIS B 1 362 ? 105.924 106.306 115.337 1.00 38.81  ? 362 HIS B C   1 
ATOM 7052 O O   . HIS B 1 362 ? 106.116 105.951 114.173 1.00 30.62  ? 362 HIS B O   1 
ATOM 7053 C CB  . HIS B 1 362 ? 105.814 104.006 116.283 1.00 41.46  ? 362 HIS B CB  1 
ATOM 7054 C CG  . HIS B 1 362 ? 106.731 102.913 116.732 1.00 40.97  ? 362 HIS B CG  1 
ATOM 7055 N ND1 . HIS B 1 362 ? 106.637 102.327 117.975 1.00 41.29  ? 362 HIS B ND1 1 
ATOM 7056 C CD2 . HIS B 1 362 ? 107.767 102.306 116.108 1.00 35.86  ? 362 HIS B CD2 1 
ATOM 7057 C CE1 . HIS B 1 362 ? 107.571 101.401 118.093 1.00 43.96  ? 362 HIS B CE1 1 
ATOM 7058 N NE2 . HIS B 1 362 ? 108.272 101.370 116.975 1.00 38.24  ? 362 HIS B NE2 1 
ATOM 7059 N N   . GLU B 1 363 ? 105.315 107.450 115.653 1.00 45.11  ? 363 GLU B N   1 
ATOM 7060 C CA  . GLU B 1 363 ? 104.766 108.338 114.627 1.00 44.58  ? 363 GLU B CA  1 
ATOM 7061 C C   . GLU B 1 363 ? 105.768 108.870 113.600 1.00 42.69  ? 363 GLU B C   1 
ATOM 7062 O O   . GLU B 1 363 ? 105.455 108.787 112.401 1.00 41.94  ? 363 GLU B O   1 
ATOM 7063 C CB  . GLU B 1 363 ? 104.029 109.504 115.298 1.00 39.82  ? 363 GLU B CB  1 
ATOM 7064 C CG  . GLU B 1 363 ? 102.809 109.122 116.121 1.00 41.52  ? 363 GLU B CG  1 
ATOM 7065 C CD  . GLU B 1 363 ? 103.147 108.760 117.555 1.00 42.27  ? 363 GLU B CD  1 
ATOM 7066 O OE1 . GLU B 1 363 ? 102.432 109.231 118.462 1.00 44.63  ? 363 GLU B OE1 1 
ATOM 7067 O OE2 . GLU B 1 363 ? 104.113 108.001 117.774 1.00 43.00  ? 363 GLU B OE2 1 
ATOM 7068 N N   . PRO B 1 364 ? 106.948 109.419 113.962 1.00 42.65  ? 364 PRO B N   1 
ATOM 7069 C CA  . PRO B 1 364 ? 107.713 110.216 112.976 1.00 50.46  ? 364 PRO B CA  1 
ATOM 7070 C C   . PRO B 1 364 ? 108.162 109.471 111.726 1.00 45.35  ? 364 PRO B C   1 
ATOM 7071 O O   . PRO B 1 364 ? 108.451 110.121 110.715 1.00 52.76  ? 364 PRO B O   1 
ATOM 7072 C CB  . PRO B 1 364 ? 108.925 110.705 113.781 1.00 53.85  ? 364 PRO B CB  1 
ATOM 7073 C CG  . PRO B 1 364 ? 109.027 109.788 114.915 1.00 46.53  ? 364 PRO B CG  1 
ATOM 7074 C CD  . PRO B 1 364 ? 107.624 109.480 115.273 1.00 43.93  ? 364 PRO B CD  1 
ATOM 7075 N N   . TYR B 1 365 ? 108.227 108.144 111.748 1.00 32.78  ? 365 TYR B N   1 
ATOM 7076 C CA  . TYR B 1 365 ? 108.401 107.396 110.514 1.00 34.78  ? 365 TYR B CA  1 
ATOM 7077 C C   . TYR B 1 365 ? 107.127 106.694 110.067 1.00 42.54  ? 365 TYR B C   1 
ATOM 7078 O O   . TYR B 1 365 ? 107.047 106.273 108.909 1.00 39.84  ? 365 TYR B O   1 
ATOM 7079 C CB  . TYR B 1 365 ? 109.541 106.379 110.655 1.00 37.36  ? 365 TYR B CB  1 
ATOM 7080 C CG  . TYR B 1 365 ? 109.165 105.079 111.321 1.00 36.13  ? 365 TYR B CG  1 
ATOM 7081 C CD1 . TYR B 1 365 ? 109.030 105.000 112.697 1.00 39.46  ? 365 TYR B CD1 1 
ATOM 7082 C CD2 . TYR B 1 365 ? 108.970 103.924 110.575 1.00 34.37  ? 365 TYR B CD2 1 
ATOM 7083 C CE1 . TYR B 1 365 ? 108.700 103.816 113.309 1.00 41.20  ? 365 TYR B CE1 1 
ATOM 7084 C CE2 . TYR B 1 365 ? 108.636 102.736 111.181 1.00 38.68  ? 365 TYR B CE2 1 
ATOM 7085 C CZ  . TYR B 1 365 ? 108.502 102.687 112.547 1.00 37.44  ? 365 TYR B CZ  1 
ATOM 7086 O OH  . TYR B 1 365 ? 108.169 101.499 113.149 1.00 28.03  ? 365 TYR B OH  1 
ATOM 7087 N N   . LEU B 1 366 ? 106.133 106.564 110.949 1.00 38.71  ? 366 LEU B N   1 
ATOM 7088 C CA  . LEU B 1 366 ? 104.845 106.020 110.533 1.00 35.25  ? 366 LEU B CA  1 
ATOM 7089 C C   . LEU B 1 366 ? 104.106 106.985 109.620 1.00 39.83  ? 366 LEU B C   1 
ATOM 7090 O O   . LEU B 1 366 ? 103.332 106.555 108.758 1.00 54.62  ? 366 LEU B O   1 
ATOM 7091 C CB  . LEU B 1 366 ? 103.992 105.695 111.756 1.00 31.27  ? 366 LEU B CB  1 
ATOM 7092 C CG  . LEU B 1 366 ? 104.057 104.249 112.231 1.00 35.16  ? 366 LEU B CG  1 
ATOM 7093 C CD1 . LEU B 1 366 ? 103.229 104.060 113.481 1.00 25.78  ? 366 LEU B CD1 1 
ATOM 7094 C CD2 . LEU B 1 366 ? 103.580 103.331 111.134 1.00 36.54  ? 366 LEU B CD2 1 
ATOM 7095 N N   . LYS B 1 367 ? 104.325 108.289 109.801 1.00 51.21  ? 367 LYS B N   1 
ATOM 7096 C CA  . LYS B 1 367 ? 103.688 109.276 108.942 1.00 45.95  ? 367 LYS B CA  1 
ATOM 7097 C C   . LYS B 1 367 ? 104.286 109.245 107.545 1.00 49.60  ? 367 LYS B C   1 
ATOM 7098 O O   . LYS B 1 367 ? 103.586 109.510 106.561 1.00 40.94  ? 367 LYS B O   1 
ATOM 7099 C CB  . LYS B 1 367 ? 103.841 110.664 109.557 1.00 42.02  ? 367 LYS B CB  1 
ATOM 7100 C CG  . LYS B 1 367 ? 103.259 110.750 110.946 1.00 47.31  ? 367 LYS B CG  1 
ATOM 7101 C CD  . LYS B 1 367 ? 101.764 110.885 110.945 1.00 46.66  ? 367 LYS B CD  1 
ATOM 7102 C CE  . LYS B 1 367 ? 101.347 111.958 111.924 1.00 54.79  ? 367 LYS B CE  1 
ATOM 7103 N NZ  . LYS B 1 367 ? 102.177 111.947 113.158 1.00 52.89  ? 367 LYS B NZ  1 
ATOM 7104 N N   . SER B 1 368 ? 105.577 108.923 107.441 1.00 51.61  ? 368 SER B N   1 
ATOM 7105 C CA  . SER B 1 368 ? 106.204 108.777 106.134 1.00 51.34  ? 368 SER B CA  1 
ATOM 7106 C C   . SER B 1 368 ? 105.797 107.475 105.461 1.00 45.91  ? 368 SER B C   1 
ATOM 7107 O O   . SER B 1 368 ? 105.920 107.351 104.238 1.00 46.98  ? 368 SER B O   1 
ATOM 7108 C CB  . SER B 1 368 ? 107.724 108.851 106.269 1.00 49.99  ? 368 SER B CB  1 
ATOM 7109 O OG  . SER B 1 368 ? 108.337 109.001 105.001 1.00 50.01  ? 368 SER B OG  1 
ATOM 7110 N N   . TRP B 1 369 ? 105.333 106.493 106.239 1.00 40.31  ? 369 TRP B N   1 
ATOM 7111 C CA  . TRP B 1 369 ? 104.816 105.261 105.651 1.00 44.90  ? 369 TRP B CA  1 
ATOM 7112 C C   . TRP B 1 369 ? 103.556 105.526 104.837 1.00 54.91  ? 369 TRP B C   1 
ATOM 7113 O O   . TRP B 1 369 ? 103.408 105.015 103.722 1.00 50.89  ? 369 TRP B O   1 
ATOM 7114 C CB  . TRP B 1 369 ? 104.527 104.237 106.746 1.00 41.36  ? 369 TRP B CB  1 
ATOM 7115 C CG  . TRP B 1 369 ? 105.716 103.454 107.188 1.00 40.47  ? 369 TRP B CG  1 
ATOM 7116 C CD1 . TRP B 1 369 ? 107.026 103.790 107.032 1.00 42.80  ? 369 TRP B CD1 1 
ATOM 7117 C CD2 . TRP B 1 369 ? 105.703 102.197 107.870 1.00 42.76  ? 369 TRP B CD2 1 
ATOM 7118 N NE1 . TRP B 1 369 ? 107.831 102.820 107.577 1.00 41.49  ? 369 TRP B NE1 1 
ATOM 7119 C CE2 . TRP B 1 369 ? 107.041 101.829 108.096 1.00 34.75  ? 369 TRP B CE2 1 
ATOM 7120 C CE3 . TRP B 1 369 ? 104.688 101.346 108.311 1.00 42.25  ? 369 TRP B CE3 1 
ATOM 7121 C CZ2 . TRP B 1 369 ? 107.390 100.648 108.740 1.00 39.97  ? 369 TRP B CZ2 1 
ATOM 7122 C CZ3 . TRP B 1 369 ? 105.036 100.180 108.952 1.00 38.68  ? 369 TRP B CZ3 1 
ATOM 7123 C CH2 . TRP B 1 369 ? 106.375 99.839  109.162 1.00 38.26  ? 369 TRP B CH2 1 
ATOM 7124 N N   . ALA B 1 370 ? 102.647 106.345 105.370 1.00 51.44  ? 370 ALA B N   1 
ATOM 7125 C CA  . ALA B 1 370 ? 101.380 106.623 104.707 1.00 40.24  ? 370 ALA B CA  1 
ATOM 7126 C C   . ALA B 1 370 ? 101.528 107.516 103.483 1.00 49.78  ? 370 ALA B C   1 
ATOM 7127 O O   . ALA B 1 370 ? 100.550 107.691 102.749 1.00 59.37  ? 370 ALA B O   1 
ATOM 7128 C CB  . ALA B 1 370 ? 100.405 107.260 105.697 1.00 42.17  ? 370 ALA B CB  1 
ATOM 7129 N N   . GLN B 1 371 ? 102.713 108.088 103.252 1.00 61.60  ? 371 GLN B N   1 
ATOM 7130 C CA  . GLN B 1 371 ? 102.915 108.956 102.097 1.00 64.99  ? 371 GLN B CA  1 
ATOM 7131 C C   . GLN B 1 371 ? 102.852 108.178 100.786 1.00 65.12  ? 371 GLN B C   1 
ATOM 7132 O O   . GLN B 1 371 ? 102.243 108.641 99.815  1.00 58.42  ? 371 GLN B O   1 
ATOM 7133 C CB  . GLN B 1 371 ? 104.252 109.685 102.225 1.00 55.81  ? 371 GLN B CB  1 
ATOM 7134 C CG  . GLN B 1 371 ? 104.459 110.818 101.230 1.00 57.65  ? 371 GLN B CG  1 
ATOM 7135 C CD  . GLN B 1 371 ? 103.338 111.836 101.253 1.00 59.82  ? 371 GLN B CD  1 
ATOM 7136 O OE1 . GLN B 1 371 ? 102.460 111.829 100.391 1.00 64.53  ? 371 GLN B OE1 1 
ATOM 7137 N NE2 . GLN B 1 371 ? 103.362 112.721 102.243 1.00 54.09  ? 371 GLN B NE2 1 
ATOM 7138 N N   . GLU B 1 372 ? 103.470 106.997 100.735 1.00 59.49  ? 372 GLU B N   1 
ATOM 7139 C CA  . GLU B 1 372 ? 103.541 106.224 99.502  1.00 57.76  ? 372 GLU B CA  1 
ATOM 7140 C C   . GLU B 1 372 ? 102.701 104.958 99.513  1.00 57.41  ? 372 GLU B C   1 
ATOM 7141 O O   . GLU B 1 372 ? 102.283 104.505 98.446  1.00 60.58  ? 372 GLU B O   1 
ATOM 7142 C CB  . GLU B 1 372 ? 104.994 105.837 99.196  1.00 55.50  ? 372 GLU B CB  1 
ATOM 7143 C CG  . GLU B 1 372 ? 106.015 106.863 99.645  1.00 56.15  ? 372 GLU B CG  1 
ATOM 7144 C CD  . GLU B 1 372 ? 106.677 106.476 100.949 1.00 58.71  ? 372 GLU B CD  1 
ATOM 7145 O OE1 . GLU B 1 372 ? 107.888 106.737 101.107 1.00 59.52  ? 372 GLU B OE1 1 
ATOM 7146 O OE2 . GLU B 1 372 ? 105.986 105.894 101.809 1.00 56.45  ? 372 GLU B OE2 1 
ATOM 7147 N N   . LEU B 1 373 ? 102.451 104.374 100.688 1.00 48.84  ? 373 LEU B N   1 
ATOM 7148 C CA  . LEU B 1 373 ? 101.715 103.115 100.747 1.00 50.42  ? 373 LEU B CA  1 
ATOM 7149 C C   . LEU B 1 373 ? 100.244 103.297 100.395 1.00 47.36  ? 373 LEU B C   1 
ATOM 7150 O O   . LEU B 1 373 ? 99.662  102.442 99.717  1.00 47.20  ? 373 LEU B O   1 
ATOM 7151 C CB  . LEU B 1 373 ? 101.861 102.491 102.135 1.00 49.40  ? 373 LEU B CB  1 
ATOM 7152 C CG  . LEU B 1 373 ? 103.264 101.988 102.470 1.00 41.65  ? 373 LEU B CG  1 
ATOM 7153 C CD1 . LEU B 1 373 ? 103.402 101.717 103.957 1.00 34.30  ? 373 LEU B CD1 1 
ATOM 7154 C CD2 . LEU B 1 373 ? 103.584 100.749 101.658 1.00 45.77  ? 373 LEU B CD2 1 
ATOM 7155 N N   . GLY B 1 374 ? 99.636  104.397 100.827 1.00 39.38  ? 374 GLY B N   1 
ATOM 7156 C CA  . GLY B 1 374 ? 98.224  104.628 100.573 1.00 41.14  ? 374 GLY B CA  1 
ATOM 7157 C C   . GLY B 1 374 ? 97.299  103.677 101.300 1.00 39.40  ? 374 GLY B C   1 
ATOM 7158 O O   . GLY B 1 374 ? 96.291  103.240 100.730 1.00 35.62  ? 374 GLY B O   1 
ATOM 7159 N N   . ALA B 1 375 ? 97.618  103.339 102.544 1.00 29.79  ? 375 ALA B N   1 
ATOM 7160 C CA  . ALA B 1 375 ? 96.803  102.451 103.353 1.00 26.16  ? 375 ALA B CA  1 
ATOM 7161 C C   . ALA B 1 375 ? 96.707  103.015 104.761 1.00 23.93  ? 375 ALA B C   1 
ATOM 7162 O O   . ALA B 1 375 ? 97.641  103.673 105.229 1.00 29.57  ? 375 ALA B O   1 
ATOM 7163 C CB  . ALA B 1 375 ? 97.395  101.034 103.395 1.00 35.78  ? 375 ALA B CB  1 
ATOM 7164 N N   . PRO B 1 376 ? 95.589  102.787 105.454 1.00 10.27  ? 376 PRO B N   1 
ATOM 7165 C CA  . PRO B 1 376 ? 95.452  103.283 106.833 1.00 12.63  ? 376 PRO B CA  1 
ATOM 7166 C C   . PRO B 1 376 ? 96.195  102.393 107.821 1.00 13.72  ? 376 PRO B C   1 
ATOM 7167 O O   . PRO B 1 376 ? 95.872  101.215 107.979 1.00 25.10  ? 376 PRO B O   1 
ATOM 7168 C CB  . PRO B 1 376 ? 93.938  103.248 107.071 1.00 18.98  ? 376 PRO B CB  1 
ATOM 7169 C CG  . PRO B 1 376 ? 93.423  102.244 106.108 1.00 15.86  ? 376 PRO B CG  1 
ATOM 7170 C CD  . PRO B 1 376 ? 94.305  102.320 104.904 1.00 4.26   ? 376 PRO B CD  1 
ATOM 7171 N N   . ILE B 1 377 ? 97.184  102.965 108.498 1.00 9.35   ? 377 ILE B N   1 
ATOM 7172 C CA  . ILE B 1 377 ? 97.968  102.245 109.496 1.00 4.75   ? 377 ILE B CA  1 
ATOM 7173 C C   . ILE B 1 377 ? 97.187  102.220 110.802 1.00 5.47   ? 377 ILE B C   1 
ATOM 7174 O O   . ILE B 1 377 ? 96.789  103.270 111.314 1.00 18.84  ? 377 ILE B O   1 
ATOM 7175 C CB  . ILE B 1 377 ? 99.356  102.882 109.711 1.00 3.63   ? 377 ILE B CB  1 
ATOM 7176 C CG1 . ILE B 1 377 ? 100.301 102.729 108.504 1.00 17.72  ? 377 ILE B CG1 1 
ATOM 7177 C CG2 . ILE B 1 377 ? 100.010 102.332 110.971 1.00 17.50  ? 377 ILE B CG2 1 
ATOM 7178 C CD1 . ILE B 1 377 ? 100.098 103.683 107.346 1.00 22.66  ? 377 ILE B CD1 1 
ATOM 7179 N N   . ILE B 1 378 ? 96.976  101.030 111.352 1.00 10.07  ? 378 ILE B N   1 
ATOM 7180 C CA  . ILE B 1 378 ? 96.442  100.885 112.703 1.00 6.27   ? 378 ILE B CA  1 
ATOM 7181 C C   . ILE B 1 378 ? 97.626  100.491 113.575 1.00 13.46  ? 378 ILE B C   1 
ATOM 7182 O O   . ILE B 1 378 ? 97.910  99.312  113.778 1.00 40.77  ? 378 ILE B O   1 
ATOM 7183 C CB  . ILE B 1 378 ? 95.321  99.856  112.773 1.00 1.00   ? 378 ILE B CB  1 
ATOM 7184 C CG1 . ILE B 1 378 ? 94.377  100.003 111.590 1.00 12.39  ? 378 ILE B CG1 1 
ATOM 7185 C CG2 . ILE B 1 378 ? 94.554  100.000 114.073 1.00 11.81  ? 378 ILE B CG2 1 
ATOM 7186 C CD1 . ILE B 1 378 ? 93.295  98.966  111.583 1.00 20.90  ? 378 ILE B CD1 1 
ATOM 7187 N N   . SER B 1 379 ? 98.307  101.485 114.126 1.00 1.00   ? 379 SER B N   1 
ATOM 7188 C CA  . SER B 1 379 ? 99.446  101.223 114.999 1.00 9.72   ? 379 SER B CA  1 
ATOM 7189 C C   . SER B 1 379 ? 98.911  100.755 116.342 1.00 13.48  ? 379 SER B C   1 
ATOM 7190 O O   . SER B 1 379 ? 98.660  101.563 117.237 1.00 32.77  ? 379 SER B O   1 
ATOM 7191 C CB  . SER B 1 379 ? 100.305 102.472 115.142 1.00 14.45  ? 379 SER B CB  1 
ATOM 7192 O OG  . SER B 1 379 ? 101.075 102.430 116.327 1.00 13.34  ? 379 SER B OG  1 
ATOM 7193 N N   . ILE B 1 380 ? 98.738  99.439  116.484 1.00 7.05   ? 380 ILE B N   1 
ATOM 7194 C CA  . ILE B 1 380 ? 98.026  98.879  117.627 1.00 5.56   ? 380 ILE B CA  1 
ATOM 7195 C C   . ILE B 1 380 ? 98.838  99.089  118.896 1.00 9.92   ? 380 ILE B C   1 
ATOM 7196 O O   . ILE B 1 380 ? 100.030 98.766  118.954 1.00 32.34  ? 380 ILE B O   1 
ATOM 7197 C CB  . ILE B 1 380 ? 97.733  97.388  117.402 1.00 17.04  ? 380 ILE B CB  1 
ATOM 7198 C CG1 . ILE B 1 380 ? 96.547  97.210  116.462 1.00 14.66  ? 380 ILE B CG1 1 
ATOM 7199 C CG2 . ILE B 1 380 ? 97.430  96.683  118.715 1.00 18.69  ? 380 ILE B CG2 1 
ATOM 7200 C CD1 . ILE B 1 380 ? 96.574  95.934  115.699 1.00 18.55  ? 380 ILE B CD1 1 
ATOM 7201 N N   . ASP B 1 381 ? 98.197  99.651  119.915 1.00 28.04  ? 381 ASP B N   1 
ATOM 7202 C CA  . ASP B 1 381 ? 98.800  99.797  121.234 1.00 32.65  ? 381 ASP B CA  1 
ATOM 7203 C C   . ASP B 1 381 ? 98.353  98.608  122.079 1.00 36.94  ? 381 ASP B C   1 
ATOM 7204 O O   . ASP B 1 381 ? 97.379  98.670  122.827 1.00 43.30  ? 381 ASP B O   1 
ATOM 7205 C CB  . ASP B 1 381 ? 98.399  101.129 121.860 1.00 47.33  ? 381 ASP B CB  1 
ATOM 7206 C CG  . ASP B 1 381 ? 99.088  101.388 123.188 1.00 34.09  ? 381 ASP B CG  1 
ATOM 7207 O OD1 . ASP B 1 381 ? 100.087 100.704 123.496 1.00 34.26  ? 381 ASP B OD1 1 
ATOM 7208 O OD2 . ASP B 1 381 ? 98.629  102.284 123.928 1.00 47.45  ? 381 ASP B OD2 1 
ATOM 7209 N N   . TYR B 1 382 ? 99.081  97.504  121.947 1.00 26.19  ? 382 TYR B N   1 
ATOM 7210 C CA  . TYR B 1 382 ? 98.793  96.348  122.778 1.00 28.03  ? 382 TYR B CA  1 
ATOM 7211 C C   . TYR B 1 382 ? 99.347  96.561  124.187 1.00 39.90  ? 382 TYR B C   1 
ATOM 7212 O O   . TYR B 1 382 ? 100.139 97.471  124.442 1.00 47.03  ? 382 TYR B O   1 
ATOM 7213 C CB  . TYR B 1 382 ? 99.363  95.075  122.153 1.00 33.97  ? 382 TYR B CB  1 
ATOM 7214 C CG  . TYR B 1 382 ? 100.809 95.159  121.719 1.00 22.18  ? 382 TYR B CG  1 
ATOM 7215 C CD1 . TYR B 1 382 ? 101.838 94.899  122.615 1.00 33.94  ? 382 TYR B CD1 1 
ATOM 7216 C CD2 . TYR B 1 382 ? 101.146 95.470  120.408 1.00 28.00  ? 382 TYR B CD2 1 
ATOM 7217 C CE1 . TYR B 1 382 ? 103.159 94.965  122.226 1.00 45.49  ? 382 TYR B CE1 1 
ATOM 7218 C CE2 . TYR B 1 382 ? 102.468 95.537  120.009 1.00 36.84  ? 382 TYR B CE2 1 
ATOM 7219 C CZ  . TYR B 1 382 ? 103.467 95.283  120.924 1.00 39.59  ? 382 TYR B CZ  1 
ATOM 7220 O OH  . TYR B 1 382 ? 104.784 95.346  120.544 1.00 12.24  ? 382 TYR B OH  1 
ATOM 7221 N N   . SER B 1 383 ? 98.910  95.711  125.112 1.00 46.12  ? 383 SER B N   1 
ATOM 7222 C CA  . SER B 1 383 ? 99.358  95.817  126.493 1.00 45.70  ? 383 SER B CA  1 
ATOM 7223 C C   . SER B 1 383 ? 100.817 95.383  126.621 1.00 43.20  ? 383 SER B C   1 
ATOM 7224 O O   . SER B 1 383 ? 101.356 94.657  125.781 1.00 37.14  ? 383 SER B O   1 
ATOM 7225 C CB  . SER B 1 383 ? 98.465  94.984  127.412 1.00 41.10  ? 383 SER B CB  1 
ATOM 7226 O OG  . SER B 1 383 ? 98.399  93.637  126.985 1.00 34.90  ? 383 SER B OG  1 
ATOM 7227 N N   . LEU B 1 384 ? 101.460 95.844  127.691 1.00 50.92  ? 384 LEU B N   1 
ATOM 7228 C CA  . LEU B 1 384 ? 102.908 95.779  127.828 1.00 48.95  ? 384 LEU B CA  1 
ATOM 7229 C C   . LEU B 1 384 ? 103.316 94.961  129.047 1.00 55.15  ? 384 LEU B C   1 
ATOM 7230 O O   . LEU B 1 384 ? 102.705 95.065  130.114 1.00 57.25  ? 384 LEU B O   1 
ATOM 7231 C CB  . LEU B 1 384 ? 103.503 97.189  127.931 1.00 50.57  ? 384 LEU B CB  1 
ATOM 7232 C CG  . LEU B 1 384 ? 103.266 98.190  126.796 1.00 47.09  ? 384 LEU B CG  1 
ATOM 7233 C CD1 . LEU B 1 384 ? 104.349 99.249  126.812 1.00 49.06  ? 384 LEU B CD1 1 
ATOM 7234 C CD2 . LEU B 1 384 ? 103.253 97.501  125.445 1.00 41.83  ? 384 LEU B CD2 1 
ATOM 7235 N N   . ALA B 1 385 ? 104.362 94.153  128.872 1.00 50.33  ? 385 ALA B N   1 
ATOM 7236 C CA  . ALA B 1 385 ? 104.973 93.404  129.958 1.00 49.06  ? 385 ALA B CA  1 
ATOM 7237 C C   . ALA B 1 385 ? 105.694 94.362  130.911 1.00 45.93  ? 385 ALA B C   1 
ATOM 7238 O O   . ALA B 1 385 ? 106.068 95.468  130.514 1.00 42.62  ? 385 ALA B O   1 
ATOM 7239 C CB  . ALA B 1 385 ? 105.944 92.378  129.375 1.00 51.70  ? 385 ALA B CB  1 
ATOM 7240 N N   . PRO B 1 386 ? 105.910 93.969  132.189 1.00 48.46  ? 386 PRO B N   1 
ATOM 7241 C CA  . PRO B 1 386 ? 105.606 92.703  132.880 1.00 50.18  ? 386 PRO B CA  1 
ATOM 7242 C C   . PRO B 1 386 ? 104.269 92.651  133.608 1.00 54.25  ? 386 PRO B C   1 
ATOM 7243 O O   . PRO B 1 386 ? 103.837 91.571  134.001 1.00 57.80  ? 386 PRO B O   1 
ATOM 7244 C CB  . PRO B 1 386 ? 106.764 92.584  133.877 1.00 56.86  ? 386 PRO B CB  1 
ATOM 7245 C CG  . PRO B 1 386 ? 107.206 94.005  134.158 1.00 57.10  ? 386 PRO B CG  1 
ATOM 7246 C CD  . PRO B 1 386 ? 106.616 94.899  133.087 1.00 53.56  ? 386 PRO B CD  1 
ATOM 7247 N N   . GLU B 1 387 ? 103.591 93.781  133.816 1.00 73.44  ? 387 GLU B N   1 
ATOM 7248 C CA  . GLU B 1 387 ? 102.291 93.750  134.473 1.00 74.48  ? 387 GLU B CA  1 
ATOM 7249 C C   . GLU B 1 387 ? 101.213 93.159  133.577 1.00 71.54  ? 387 GLU B C   1 
ATOM 7250 O O   . GLU B 1 387 ? 100.159 92.753  134.078 1.00 70.42  ? 387 GLU B O   1 
ATOM 7251 C CB  . GLU B 1 387 ? 101.894 95.156  134.922 1.00 76.93  ? 387 GLU B CB  1 
ATOM 7252 C CG  . GLU B 1 387 ? 102.790 95.728  136.007 1.00 79.44  ? 387 GLU B CG  1 
ATOM 7253 C CD  . GLU B 1 387 ? 102.819 94.864  137.254 1.00 80.25  ? 387 GLU B CD  1 
ATOM 7254 O OE1 . GLU B 1 387 ? 101.736 94.451  137.719 1.00 79.13  ? 387 GLU B OE1 1 
ATOM 7255 O OE2 . GLU B 1 387 ? 103.926 94.596  137.767 1.00 77.53  ? 387 GLU B OE2 1 
ATOM 7256 N N   . ALA B 1 388 ? 101.456 93.099  132.271 1.00 62.98  ? 388 ALA B N   1 
ATOM 7257 C CA  . ALA B 1 388 ? 100.551 92.464  131.317 1.00 61.47  ? 388 ALA B CA  1 
ATOM 7258 C C   . ALA B 1 388 ? 101.358 91.508  130.447 1.00 66.82  ? 388 ALA B C   1 
ATOM 7259 O O   . ALA B 1 388 ? 101.663 91.811  129.285 1.00 64.49  ? 388 ALA B O   1 
ATOM 7260 C CB  . ALA B 1 388 ? 99.823  93.510  130.475 1.00 60.93  ? 388 ALA B CB  1 
ATOM 7261 N N   . PRO B 1 389 ? 101.720 90.332  130.979 1.00 58.27  ? 389 PRO B N   1 
ATOM 7262 C CA  . PRO B 1 389 ? 102.481 89.364  130.181 1.00 48.14  ? 389 PRO B CA  1 
ATOM 7263 C C   . PRO B 1 389 ? 101.577 88.573  129.253 1.00 51.16  ? 389 PRO B C   1 
ATOM 7264 O O   . PRO B 1 389 ? 100.399 88.911  129.104 1.00 54.94  ? 389 PRO B O   1 
ATOM 7265 C CB  . PRO B 1 389 ? 103.126 88.470  131.244 1.00 50.56  ? 389 PRO B CB  1 
ATOM 7266 C CG  . PRO B 1 389 ? 102.196 88.537  132.414 1.00 56.23  ? 389 PRO B CG  1 
ATOM 7267 C CD  . PRO B 1 389 ? 101.346 89.782  132.293 1.00 56.51  ? 389 PRO B CD  1 
ATOM 7268 N N   . PHE B 1 390 ? 102.113 87.546  128.598 1.00 58.80  ? 390 PHE B N   1 
ATOM 7269 C CA  . PHE B 1 390 ? 101.262 86.667  127.814 1.00 62.89  ? 390 PHE B CA  1 
ATOM 7270 C C   . PHE B 1 390 ? 100.323 85.914  128.757 1.00 54.78  ? 390 PHE B C   1 
ATOM 7271 O O   . PHE B 1 390 ? 100.707 85.557  129.875 1.00 57.21  ? 390 PHE B O   1 
ATOM 7272 C CB  . PHE B 1 390 ? 102.091 85.679  126.986 1.00 61.54  ? 390 PHE B CB  1 
ATOM 7273 C CG  . PHE B 1 390 ? 102.681 84.543  127.782 1.00 56.22  ? 390 PHE B CG  1 
ATOM 7274 C CD1 . PHE B 1 390 ? 102.211 83.250  127.611 1.00 58.27  ? 390 PHE B CD1 1 
ATOM 7275 C CD2 . PHE B 1 390 ? 103.691 84.760  128.697 1.00 57.36  ? 390 PHE B CD2 1 
ATOM 7276 C CE1 . PHE B 1 390 ? 102.744 82.201  128.336 1.00 59.24  ? 390 PHE B CE1 1 
ATOM 7277 C CE2 . PHE B 1 390 ? 104.225 83.718  129.425 1.00 57.82  ? 390 PHE B CE2 1 
ATOM 7278 C CZ  . PHE B 1 390 ? 103.753 82.438  129.245 1.00 55.10  ? 390 PHE B CZ  1 
ATOM 7279 N N   . PRO B 1 391 ? 99.076  85.675  128.346 1.00 41.97  ? 391 PRO B N   1 
ATOM 7280 C CA  . PRO B 1 391 ? 98.458  85.991  127.055 1.00 54.19  ? 391 PRO B CA  1 
ATOM 7281 C C   . PRO B 1 391 ? 97.759  87.352  126.986 1.00 55.76  ? 391 PRO B C   1 
ATOM 7282 O O   . PRO B 1 391 ? 97.112  87.632  125.982 1.00 61.12  ? 391 PRO B O   1 
ATOM 7283 C CB  . PRO B 1 391 ? 97.457  84.837  126.875 1.00 54.02  ? 391 PRO B CB  1 
ATOM 7284 C CG  . PRO B 1 391 ? 97.254  84.217  128.265 1.00 54.11  ? 391 PRO B CG  1 
ATOM 7285 C CD  . PRO B 1 391 ? 98.132  84.974  129.226 1.00 54.38  ? 391 PRO B CD  1 
ATOM 7286 N N   . ARG B 1 392 ? 97.851  88.206  128.012 1.00 59.06  ? 392 ARG B N   1 
ATOM 7287 C CA  . ARG B 1 392 ? 97.225  89.526  127.940 1.00 59.30  ? 392 ARG B CA  1 
ATOM 7288 C C   . ARG B 1 392 ? 97.869  90.383  126.857 1.00 62.73  ? 392 ARG B C   1 
ATOM 7289 O O   . ARG B 1 392 ? 97.174  91.090  126.118 1.00 57.39  ? 392 ARG B O   1 
ATOM 7290 C CB  . ARG B 1 392 ? 97.309  90.220  129.300 1.00 58.58  ? 392 ARG B CB  1 
ATOM 7291 C CG  . ARG B 1 392 ? 96.852  91.675  129.322 1.00 60.16  ? 392 ARG B CG  1 
ATOM 7292 C CD  . ARG B 1 392 ? 95.441  91.860  128.797 1.00 61.89  ? 392 ARG B CD  1 
ATOM 7293 N NE  . ARG B 1 392 ? 94.440  91.839  129.854 1.00 60.95  ? 392 ARG B NE  1 
ATOM 7294 C CZ  . ARG B 1 392 ? 93.202  91.396  129.690 1.00 60.00  ? 392 ARG B CZ  1 
ATOM 7295 N NH1 . ARG B 1 392 ? 92.778  90.956  128.519 1.00 59.74  ? 392 ARG B NH1 1 
ATOM 7296 N NH2 . ARG B 1 392 ? 92.367  91.403  130.724 1.00 62.17  ? 392 ARG B NH2 1 
ATOM 7297 N N   . ALA B 1 393 ? 99.193  90.313  126.731 1.00 56.04  ? 393 ALA B N   1 
ATOM 7298 C CA  . ALA B 1 393 ? 99.883  90.993  125.643 1.00 54.84  ? 393 ALA B CA  1 
ATOM 7299 C C   . ALA B 1 393 ? 99.755  90.255  124.317 1.00 48.17  ? 393 ALA B C   1 
ATOM 7300 O O   . ALA B 1 393 ? 100.314 90.716  123.317 1.00 39.81  ? 393 ALA B O   1 
ATOM 7301 C CB  . ALA B 1 393 ? 101.360 91.180  125.997 1.00 44.99  ? 393 ALA B CB  1 
ATOM 7302 N N   . LEU B 1 394 ? 99.047  89.126  124.290 1.00 49.83  ? 394 LEU B N   1 
ATOM 7303 C CA  . LEU B 1 394 ? 98.918  88.282  123.113 1.00 47.30  ? 394 LEU B CA  1 
ATOM 7304 C C   . LEU B 1 394 ? 97.528  88.298  122.498 1.00 55.79  ? 394 LEU B C   1 
ATOM 7305 O O   . LEU B 1 394 ? 97.413  88.280  121.271 1.00 59.49  ? 394 LEU B O   1 
ATOM 7306 C CB  . LEU B 1 394 ? 99.298  86.837  123.470 1.00 48.51  ? 394 LEU B CB  1 
ATOM 7307 C CG  . LEU B 1 394 ? 98.751  85.650  122.675 1.00 49.66  ? 394 LEU B CG  1 
ATOM 7308 C CD1 . LEU B 1 394 ? 99.516  85.481  121.385 1.00 41.69  ? 394 LEU B CD1 1 
ATOM 7309 C CD2 . LEU B 1 394 ? 98.819  84.376  123.496 1.00 48.95  ? 394 LEU B CD2 1 
ATOM 7310 N N   . GLU B 1 395 ? 96.470  88.352  123.312 1.00 52.68  ? 395 GLU B N   1 
ATOM 7311 C CA  . GLU B 1 395 ? 95.109  88.300  122.797 1.00 45.99  ? 395 GLU B CA  1 
ATOM 7312 C C   . GLU B 1 395 ? 94.479  89.661  122.535 1.00 49.64  ? 395 GLU B C   1 
ATOM 7313 O O   . GLU B 1 395 ? 93.541  89.734  121.735 1.00 49.91  ? 395 GLU B O   1 
ATOM 7314 C CB  . GLU B 1 395 ? 94.200  87.508  123.749 1.00 45.96  ? 395 GLU B CB  1 
ATOM 7315 C CG  . GLU B 1 395 ? 94.798  86.200  124.231 1.00 46.60  ? 395 GLU B CG  1 
ATOM 7316 C CD  . GLU B 1 395 ? 93.925  85.500  125.249 1.00 49.24  ? 395 GLU B CD  1 
ATOM 7317 O OE1 . GLU B 1 395 ? 93.640  84.299  125.063 1.00 49.84  ? 395 GLU B OE1 1 
ATOM 7318 O OE2 . GLU B 1 395 ? 93.524  86.149  126.236 1.00 54.73  ? 395 GLU B OE2 1 
ATOM 7319 N N   . GLU B 1 396 ? 94.950  90.730  123.189 1.00 48.81  ? 396 GLU B N   1 
ATOM 7320 C CA  . GLU B 1 396 ? 94.462  92.069  122.865 1.00 53.02  ? 396 GLU B CA  1 
ATOM 7321 C C   . GLU B 1 396 ? 94.810  92.447  121.435 1.00 46.65  ? 396 GLU B C   1 
ATOM 7322 O O   . GLU B 1 396 ? 93.966  92.960  120.693 1.00 47.11  ? 396 GLU B O   1 
ATOM 7323 C CB  . GLU B 1 396 ? 95.045  93.102  123.828 1.00 48.06  ? 396 GLU B CB  1 
ATOM 7324 C CG  . GLU B 1 396 ? 94.423  93.126  125.208 1.00 55.54  ? 396 GLU B CG  1 
ATOM 7325 C CD  . GLU B 1 396 ? 94.930  94.294  126.029 1.00 48.65  ? 396 GLU B CD  1 
ATOM 7326 O OE1 . GLU B 1 396 ? 95.810  95.026  125.529 1.00 47.85  ? 396 GLU B OE1 1 
ATOM 7327 O OE2 . GLU B 1 396 ? 94.445  94.491  127.163 1.00 48.74  ? 396 GLU B OE2 1 
ATOM 7328 N N   . CYS B 1 397 ? 96.053  92.196  121.030 1.00 40.92  ? 397 CYS B N   1 
ATOM 7329 C CA  . CYS B 1 397 ? 96.429  92.377  119.639 1.00 38.31  ? 397 CYS B CA  1 
ATOM 7330 C C   . CYS B 1 397 ? 95.806  91.318  118.748 1.00 35.27  ? 397 CYS B C   1 
ATOM 7331 O O   . CYS B 1 397 ? 95.668  91.543  117.543 1.00 32.70  ? 397 CYS B O   1 
ATOM 7332 C CB  . CYS B 1 397 ? 97.946  92.347  119.501 1.00 42.11  ? 397 CYS B CB  1 
ATOM 7333 S SG  . CYS B 1 397 ? 98.767  91.212  120.623 1.00 41.17  ? 397 CYS B SG  1 
ATOM 7334 N N   . PHE B 1 398 ? 95.447  90.162  119.307 1.00 44.86  ? 398 PHE B N   1 
ATOM 7335 C CA  . PHE B 1 398 ? 94.629  89.220  118.556 1.00 44.74  ? 398 PHE B CA  1 
ATOM 7336 C C   . PHE B 1 398 ? 93.209  89.747  118.395 1.00 46.95  ? 398 PHE B C   1 
ATOM 7337 O O   . PHE B 1 398 ? 92.609  89.606  117.325 1.00 49.37  ? 398 PHE B O   1 
ATOM 7338 C CB  . PHE B 1 398 ? 94.629  87.851  119.236 1.00 42.50  ? 398 PHE B CB  1 
ATOM 7339 C CG  . PHE B 1 398 ? 93.916  86.788  118.454 1.00 52.24  ? 398 PHE B CG  1 
ATOM 7340 C CD1 . PHE B 1 398 ? 94.151  86.633  117.096 1.00 48.44  ? 398 PHE B CD1 1 
ATOM 7341 C CD2 . PHE B 1 398 ? 93.014  85.940  119.075 1.00 52.38  ? 398 PHE B CD2 1 
ATOM 7342 C CE1 . PHE B 1 398 ? 93.496  85.655  116.371 1.00 50.17  ? 398 PHE B CE1 1 
ATOM 7343 C CE2 . PHE B 1 398 ? 92.357  84.960  118.357 1.00 44.76  ? 398 PHE B CE2 1 
ATOM 7344 C CZ  . PHE B 1 398 ? 92.597  84.818  117.003 1.00 44.49  ? 398 PHE B CZ  1 
ATOM 7345 N N   . PHE B 1 399 ? 92.662  90.366  119.446 1.00 47.60  ? 399 PHE B N   1 
ATOM 7346 C CA  . PHE B 1 399 ? 91.323  90.947  119.367 1.00 57.24  ? 399 PHE B CA  1 
ATOM 7347 C C   . PHE B 1 399 ? 91.274  92.110  118.380 1.00 60.18  ? 399 PHE B C   1 
ATOM 7348 O O   . PHE B 1 399 ? 90.333  92.214  117.584 1.00 58.35  ? 399 PHE B O   1 
ATOM 7349 C CB  . PHE B 1 399 ? 90.880  91.402  120.758 1.00 60.13  ? 399 PHE B CB  1 
ATOM 7350 C CG  . PHE B 1 399 ? 89.400  91.299  120.996 1.00 60.02  ? 399 PHE B CG  1 
ATOM 7351 C CD1 . PHE B 1 399 ? 88.800  90.066  121.194 1.00 57.57  ? 399 PHE B CD1 1 
ATOM 7352 C CD2 . PHE B 1 399 ? 88.612  92.436  121.038 1.00 56.46  ? 399 PHE B CD2 1 
ATOM 7353 C CE1 . PHE B 1 399 ? 87.441  89.968  121.422 1.00 53.94  ? 399 PHE B CE1 1 
ATOM 7354 C CE2 . PHE B 1 399 ? 87.254  92.344  121.263 1.00 56.45  ? 399 PHE B CE2 1 
ATOM 7355 C CZ  . PHE B 1 399 ? 86.669  91.108  121.455 1.00 57.92  ? 399 PHE B CZ  1 
ATOM 7356 N N   . ALA B 1 400 ? 92.285  92.989  118.416 1.00 57.75  ? 400 ALA B N   1 
ATOM 7357 C CA  . ALA B 1 400 ? 92.315  94.157  117.538 1.00 50.62  ? 400 ALA B CA  1 
ATOM 7358 C C   . ALA B 1 400 ? 92.438  93.759  116.078 1.00 46.62  ? 400 ALA B C   1 
ATOM 7359 O O   . ALA B 1 400 ? 91.788  94.353  115.210 1.00 36.29  ? 400 ALA B O   1 
ATOM 7360 C CB  . ALA B 1 400 ? 93.478  95.069  117.911 1.00 44.79  ? 400 ALA B CB  1 
ATOM 7361 N N   . TYR B 1 401 ? 93.297  92.784  115.787 1.00 60.28  ? 401 TYR B N   1 
ATOM 7362 C CA  . TYR B 1 401 ? 93.385  92.261  114.432 1.00 52.99  ? 401 TYR B CA  1 
ATOM 7363 C C   . TYR B 1 401 ? 92.084  91.586  114.026 1.00 44.25  ? 401 TYR B C   1 
ATOM 7364 O O   . TYR B 1 401 ? 91.649  91.714  112.877 1.00 48.22  ? 401 TYR B O   1 
ATOM 7365 C CB  . TYR B 1 401 ? 94.554  91.286  114.314 1.00 54.65  ? 401 TYR B CB  1 
ATOM 7366 C CG  . TYR B 1 401 ? 94.650  90.660  112.948 1.00 48.27  ? 401 TYR B CG  1 
ATOM 7367 C CD1 . TYR B 1 401 ? 94.600  91.441  111.802 1.00 43.09  ? 401 TYR B CD1 1 
ATOM 7368 C CD2 . TYR B 1 401 ? 94.750  89.286  112.803 1.00 47.21  ? 401 TYR B CD2 1 
ATOM 7369 C CE1 . TYR B 1 401 ? 94.668  90.875  110.553 1.00 43.67  ? 401 TYR B CE1 1 
ATOM 7370 C CE2 . TYR B 1 401 ? 94.819  88.709  111.554 1.00 49.84  ? 401 TYR B CE2 1 
ATOM 7371 C CZ  . TYR B 1 401 ? 94.778  89.510  110.435 1.00 51.20  ? 401 TYR B CZ  1 
ATOM 7372 O OH  . TYR B 1 401 ? 94.843  88.946  109.186 1.00 49.29  ? 401 TYR B OH  1 
ATOM 7373 N N   . CYS B 1 402 ? 91.447  90.867  114.956 1.00 49.50  ? 402 CYS B N   1 
ATOM 7374 C CA  . CYS B 1 402 ? 90.178  90.214  114.647 1.00 56.26  ? 402 CYS B CA  1 
ATOM 7375 C C   . CYS B 1 402 ? 89.059  91.220  114.414 1.00 65.17  ? 402 CYS B C   1 
ATOM 7376 O O   . CYS B 1 402 ? 88.202  90.998  113.551 1.00 60.51  ? 402 CYS B O   1 
ATOM 7377 C CB  . CYS B 1 402 ? 89.790  89.248  115.764 1.00 55.96  ? 402 CYS B CB  1 
ATOM 7378 S SG  . CYS B 1 402 ? 90.661  87.667  115.702 1.00 82.29  ? 402 CYS B SG  1 
ATOM 7379 N N   . TRP B 1 403 ? 89.045  92.321  115.166 1.00 64.80  ? 403 TRP B N   1 
ATOM 7380 C CA  . TRP B 1 403 ? 87.997  93.321  114.999 1.00 61.16  ? 403 TRP B CA  1 
ATOM 7381 C C   . TRP B 1 403 ? 88.117  94.065  113.673 1.00 65.18  ? 403 TRP B C   1 
ATOM 7382 O O   . TRP B 1 403 ? 87.108  94.540  113.142 1.00 61.26  ? 403 TRP B O   1 
ATOM 7383 C CB  . TRP B 1 403 ? 88.029  94.298  116.175 1.00 62.70  ? 403 TRP B CB  1 
ATOM 7384 C CG  . TRP B 1 403 ? 87.041  95.417  116.083 1.00 59.69  ? 403 TRP B CG  1 
ATOM 7385 C CD1 . TRP B 1 403 ? 85.712  95.367  116.384 1.00 60.97  ? 403 TRP B CD1 1 
ATOM 7386 C CD2 . TRP B 1 403 ? 87.310  96.759  115.673 1.00 58.83  ? 403 TRP B CD2 1 
ATOM 7387 N NE1 . TRP B 1 403 ? 85.135  96.596  116.182 1.00 61.11  ? 403 TRP B NE1 1 
ATOM 7388 C CE2 . TRP B 1 403 ? 86.097  97.468  115.745 1.00 53.64  ? 403 TRP B CE2 1 
ATOM 7389 C CE3 . TRP B 1 403 ? 88.459  97.430  115.246 1.00 62.42  ? 403 TRP B CE3 1 
ATOM 7390 C CZ2 . TRP B 1 403 ? 86.001  98.813  115.410 1.00 62.86  ? 403 TRP B CZ2 1 
ATOM 7391 C CZ3 . TRP B 1 403 ? 88.362  98.765  114.918 1.00 60.09  ? 403 TRP B CZ3 1 
ATOM 7392 C CH2 . TRP B 1 403 ? 87.143  99.442  115.000 1.00 60.46  ? 403 TRP B CH2 1 
ATOM 7393 N N   . ALA B 1 404 ? 89.324  94.154  113.115 1.00 63.96  ? 404 ALA B N   1 
ATOM 7394 C CA  . ALA B 1 404 ? 89.544  94.888  111.877 1.00 58.05  ? 404 ALA B CA  1 
ATOM 7395 C C   . ALA B 1 404 ? 89.185  94.093  110.629 1.00 52.55  ? 404 ALA B C   1 
ATOM 7396 O O   . ALA B 1 404 ? 89.210  94.659  109.532 1.00 51.48  ? 404 ALA B O   1 
ATOM 7397 C CB  . ALA B 1 404 ? 91.003  95.338  111.787 1.00 57.43  ? 404 ALA B CB  1 
ATOM 7398 N N   . ILE B 1 405 ? 88.865  92.805  110.757 1.00 61.17  ? 405 ILE B N   1 
ATOM 7399 C CA  . ILE B 1 405 ? 88.451  92.042  109.583 1.00 66.85  ? 405 ILE B CA  1 
ATOM 7400 C C   . ILE B 1 405 ? 86.990  92.319  109.249 1.00 70.26  ? 405 ILE B C   1 
ATOM 7401 O O   . ILE B 1 405 ? 86.569  92.162  108.096 1.00 70.38  ? 405 ILE B O   1 
ATOM 7402 C CB  . ILE B 1 405 ? 88.691  90.535  109.798 1.00 68.19  ? 405 ILE B CB  1 
ATOM 7403 C CG1 . ILE B 1 405 ? 89.975  90.288  110.583 1.00 65.61  ? 405 ILE B CG1 1 
ATOM 7404 C CG2 . ILE B 1 405 ? 88.763  89.798  108.469 1.00 70.64  ? 405 ILE B CG2 1 
ATOM 7405 C CD1 . ILE B 1 405 ? 90.059  88.903  111.186 1.00 66.18  ? 405 ILE B CD1 1 
ATOM 7406 N N   . LYS B 1 406 ? 86.192  92.716  110.239 1.00 72.89  ? 406 LYS B N   1 
ATOM 7407 C CA  . LYS B 1 406 ? 84.748  92.845  110.078 1.00 69.17  ? 406 LYS B CA  1 
ATOM 7408 C C   . LYS B 1 406 ? 84.324  94.304  110.009 1.00 73.14  ? 406 LYS B C   1 
ATOM 7409 O O   . LYS B 1 406 ? 83.512  94.682  109.160 1.00 73.25  ? 406 LYS B O   1 
ATOM 7410 C CB  . LYS B 1 406 ? 83.970  92.139  111.213 1.00 66.54  ? 406 LYS B CB  1 
ATOM 7411 C CG  . LYS B 1 406 ? 83.998  90.577  111.331 1.00 69.49  ? 406 LYS B CG  1 
ATOM 7412 C CD  . LYS B 1 406 ? 85.353  89.912  111.158 1.00 75.22  ? 406 LYS B CD  1 
ATOM 7413 C CE  . LYS B 1 406 ? 85.326  88.434  111.225 1.00 70.50  ? 406 LYS B CE  1 
ATOM 7414 N NZ  . LYS B 1 406 ? 86.664  87.865  110.880 1.00 70.52  ? 406 LYS B NZ  1 
ATOM 7415 N N   . HIS B 1 407 ? 84.876  95.135  110.891 1.00 72.97  ? 407 HIS B N   1 
ATOM 7416 C CA  . HIS B 1 407 ? 84.640  96.575  110.874 1.00 68.94  ? 407 HIS B CA  1 
ATOM 7417 C C   . HIS B 1 407 ? 85.669  97.220  109.943 1.00 64.30  ? 407 HIS B C   1 
ATOM 7418 O O   . HIS B 1 407 ? 86.538  97.995  110.346 1.00 61.70  ? 407 HIS B O   1 
ATOM 7419 C CB  . HIS B 1 407 ? 84.713  97.139  112.287 1.00 69.66  ? 407 HIS B CB  1 
ATOM 7420 C CG  . HIS B 1 407 ? 83.695  96.561  113.224 1.00 74.59  ? 407 HIS B CG  1 
ATOM 7421 N ND1 . HIS B 1 407 ? 82.664  97.306  113.755 1.00 78.58  ? 407 HIS B ND1 1 
ATOM 7422 C CD2 . HIS B 1 407 ? 83.551  95.311  113.724 1.00 73.11  ? 407 HIS B CD2 1 
ATOM 7423 C CE1 . HIS B 1 407 ? 81.930  96.540  114.542 1.00 72.62  ? 407 HIS B CE1 1 
ATOM 7424 N NE2 . HIS B 1 407 ? 82.446  95.325  114.540 1.00 73.15  ? 407 HIS B NE2 1 
ATOM 7425 N N   . CYS B 1 408 ? 85.560  96.864  108.662 1.00 59.55  ? 408 CYS B N   1 
ATOM 7426 C CA  . CYS B 1 408 ? 86.524  97.322  107.669 1.00 57.13  ? 408 CYS B CA  1 
ATOM 7427 C C   . CYS B 1 408 ? 86.222  98.743  107.212 1.00 64.59  ? 408 CYS B C   1 
ATOM 7428 O O   . CYS B 1 408 ? 87.128  99.579  107.127 1.00 61.12  ? 408 CYS B O   1 
ATOM 7429 C CB  . CYS B 1 408 ? 86.537  96.371  106.474 1.00 58.23  ? 408 CYS B CB  1 
ATOM 7430 S SG  . CYS B 1 408 ? 87.512  94.882  106.728 1.00 80.07  ? 408 CYS B SG  1 
ATOM 7431 N N   . ALA B 1 409 ? 84.955  99.029  106.899 1.00 63.36  ? 409 ALA B N   1 
ATOM 7432 C CA  . ALA B 1 409 ? 84.583  100.375 106.476 1.00 61.97  ? 409 ALA B CA  1 
ATOM 7433 C C   . ALA B 1 409 ? 84.687  101.370 107.621 1.00 63.18  ? 409 ALA B C   1 
ATOM 7434 O O   . ALA B 1 409 ? 84.942  102.556 107.387 1.00 64.08  ? 409 ALA B O   1 
ATOM 7435 C CB  . ALA B 1 409 ? 83.170  100.373 105.898 1.00 65.32  ? 409 ALA B CB  1 
ATOM 7436 N N   . LEU B 1 410 ? 84.501  100.904 108.858 1.00 67.10  ? 410 LEU B N   1 
ATOM 7437 C CA  . LEU B 1 410 ? 84.602  101.780 110.020 1.00 70.32  ? 410 LEU B CA  1 
ATOM 7438 C C   . LEU B 1 410 ? 86.032  102.266 110.231 1.00 60.79  ? 410 LEU B C   1 
ATOM 7439 O O   . LEU B 1 410 ? 86.241  103.325 110.832 1.00 63.55  ? 410 LEU B O   1 
ATOM 7440 C CB  . LEU B 1 410 ? 84.076  101.045 111.255 1.00 68.96  ? 410 LEU B CB  1 
ATOM 7441 C CG  . LEU B 1 410 ? 83.766  101.783 112.560 1.00 72.42  ? 410 LEU B CG  1 
ATOM 7442 C CD1 . LEU B 1 410 ? 82.632  101.072 113.272 1.00 64.59  ? 410 LEU B CD1 1 
ATOM 7443 C CD2 . LEU B 1 410 ? 84.971  101.845 113.474 1.00 58.49  ? 410 LEU B CD2 1 
ATOM 7444 N N   . LEU B 1 411 ? 87.019  101.517 109.746 1.00 47.07  ? 411 LEU B N   1 
ATOM 7445 C CA  . LEU B 1 411 ? 88.414  101.934 109.766 1.00 47.45  ? 411 LEU B CA  1 
ATOM 7446 C C   . LEU B 1 411 ? 88.857  102.547 108.445 1.00 46.99  ? 411 LEU B C   1 
ATOM 7447 O O   . LEU B 1 411 ? 90.048  102.827 108.274 1.00 48.26  ? 411 LEU B O   1 
ATOM 7448 C CB  . LEU B 1 411 ? 89.312  100.746 110.111 1.00 50.94  ? 411 LEU B CB  1 
ATOM 7449 C CG  . LEU B 1 411 ? 89.192  100.215 111.538 1.00 51.70  ? 411 LEU B CG  1 
ATOM 7450 C CD1 . LEU B 1 411 ? 89.592  98.759  111.571 1.00 50.86  ? 411 LEU B CD1 1 
ATOM 7451 C CD2 . LEU B 1 411 ? 90.053  101.030 112.489 1.00 47.81  ? 411 LEU B CD2 1 
ATOM 7452 N N   . GLY B 1 412 ? 87.931  102.770 107.521 1.00 40.61  ? 412 GLY B N   1 
ATOM 7453 C CA  . GLY B 1 412 ? 88.283  103.266 106.205 1.00 47.38  ? 412 GLY B CA  1 
ATOM 7454 C C   . GLY B 1 412 ? 89.060  102.279 105.365 1.00 44.76  ? 412 GLY B C   1 
ATOM 7455 O O   . GLY B 1 412 ? 90.014  102.669 104.682 1.00 46.51  ? 412 GLY B O   1 
ATOM 7456 N N   . SER B 1 413 ? 88.678  101.003 105.402 1.00 51.42  ? 413 SER B N   1 
ATOM 7457 C CA  . SER B 1 413 ? 89.338  99.958  104.633 1.00 54.12  ? 413 SER B CA  1 
ATOM 7458 C C   . SER B 1 413 ? 88.276  99.026  104.066 1.00 52.47  ? 413 SER B C   1 
ATOM 7459 O O   . SER B 1 413 ? 87.073  99.271  104.189 1.00 52.45  ? 413 SER B O   1 
ATOM 7460 C CB  . SER B 1 413 ? 90.341  99.181  105.491 1.00 45.97  ? 413 SER B CB  1 
ATOM 7461 O OG  . SER B 1 413 ? 89.700  98.124  106.181 1.00 47.11  ? 413 SER B OG  1 
ATOM 7462 N N   . THR B 1 414 ? 88.730  97.946  103.436 1.00 44.33  ? 414 THR B N   1 
ATOM 7463 C CA  . THR B 1 414 ? 87.817  96.957  102.883 1.00 50.90  ? 414 THR B CA  1 
ATOM 7464 C C   . THR B 1 414 ? 88.195  95.567  103.369 1.00 51.64  ? 414 THR B C   1 
ATOM 7465 O O   . THR B 1 414 ? 87.341  94.681  103.470 1.00 53.05  ? 414 THR B O   1 
ATOM 7466 C CB  . THR B 1 414 ? 87.827  97.010  101.356 1.00 52.74  ? 414 THR B CB  1 
ATOM 7467 O OG1 . THR B 1 414 ? 87.902  98.374  100.930 0.75 53.36  ? 414 THR B OG1 1 
ATOM 7468 C CG2 . THR B 1 414 ? 86.560  96.387  100.790 1.00 52.82  ? 414 THR B CG2 1 
ATOM 7469 N N   . GLY B 1 415 ? 89.471  95.372  103.684 1.00 54.62  ? 415 GLY B N   1 
ATOM 7470 C CA  . GLY B 1 415 ? 89.947  94.080  104.127 1.00 54.72  ? 415 GLY B CA  1 
ATOM 7471 C C   . GLY B 1 415 ? 90.242  93.094  103.024 1.00 54.80  ? 415 GLY B C   1 
ATOM 7472 O O   . GLY B 1 415 ? 90.304  91.888  103.293 1.00 54.90  ? 415 GLY B O   1 
ATOM 7473 N N   . GLU B 1 416 ? 90.418  93.561  101.785 1.00 57.47  ? 416 GLU B N   1 
ATOM 7474 C CA  . GLU B 1 416 ? 90.777  92.671  100.689 1.00 60.16  ? 416 GLU B CA  1 
ATOM 7475 C C   . GLU B 1 416 ? 92.207  92.165  100.792 1.00 58.71  ? 416 GLU B C   1 
ATOM 7476 O O   . GLU B 1 416 ? 92.547  91.171  100.142 1.00 62.21  ? 416 GLU B O   1 
ATOM 7477 C CB  . GLU B 1 416 ? 90.579  93.375  99.346  1.00 58.26  ? 416 GLU B CB  1 
ATOM 7478 C CG  . GLU B 1 416 ? 89.122  93.570  98.955  1.00 57.70  ? 416 GLU B CG  1 
ATOM 7479 C CD  . GLU B 1 416 ? 88.402  92.266  98.656  1.00 63.65  ? 416 GLU B CD  1 
ATOM 7480 O OE1 . GLU B 1 416 ? 87.157  92.247  98.743  1.00 68.34  ? 416 GLU B OE1 1 
ATOM 7481 O OE2 . GLU B 1 416 ? 89.070  91.268  98.310  1.00 62.83  ? 416 GLU B OE2 1 
ATOM 7482 N N   . ARG B 1 417 ? 93.043  92.822  101.590 1.00 46.04  ? 417 ARG B N   1 
ATOM 7483 C CA  . ARG B 1 417 ? 94.419  92.398  101.785 1.00 44.02  ? 417 ARG B CA  1 
ATOM 7484 C C   . ARG B 1 417 ? 94.922  92.945  103.110 1.00 39.16  ? 417 ARG B C   1 
ATOM 7485 O O   . ARG B 1 417 ? 94.641  94.088  103.474 1.00 40.85  ? 417 ARG B O   1 
ATOM 7486 C CB  . ARG B 1 417 ? 95.314  92.871  100.639 1.00 40.32  ? 417 ARG B CB  1 
ATOM 7487 C CG  . ARG B 1 417 ? 96.741  92.401  100.735 1.00 44.98  ? 417 ARG B CG  1 
ATOM 7488 C CD  . ARG B 1 417 ? 97.470  92.675  99.453  1.00 51.69  ? 417 ARG B CD  1 
ATOM 7489 N NE  . ARG B 1 417 ? 96.607  92.436  98.305  1.00 51.34  ? 417 ARG B NE  1 
ATOM 7490 C CZ  . ARG B 1 417 ? 96.722  91.397  97.493  1.00 46.94  ? 417 ARG B CZ  1 
ATOM 7491 N NH1 . ARG B 1 417 ? 97.648  90.472  97.685  1.00 45.19  ? 417 ARG B NH1 1 
ATOM 7492 N NH2 . ARG B 1 417 ? 95.878  91.275  96.473  1.00 44.73  ? 417 ARG B NH2 1 
ATOM 7493 N N   . ILE B 1 418 ? 95.666  92.116  103.828 1.00 20.44  ? 418 ILE B N   1 
ATOM 7494 C CA  . ILE B 1 418 ? 96.278  92.506  105.087 1.00 16.84  ? 418 ILE B CA  1 
ATOM 7495 C C   . ILE B 1 418 ? 97.783  92.490  104.890 1.00 21.69  ? 418 ILE B C   1 
ATOM 7496 O O   . ILE B 1 418 ? 98.354  91.459  104.519 1.00 46.88  ? 418 ILE B O   1 
ATOM 7497 C CB  . ILE B 1 418 ? 95.872  91.572  106.237 1.00 32.60  ? 418 ILE B CB  1 
ATOM 7498 C CG1 . ILE B 1 418 ? 94.389  91.195  106.139 1.00 31.82  ? 418 ILE B CG1 1 
ATOM 7499 C CG2 . ILE B 1 418 ? 96.208  92.202  107.576 1.00 26.96  ? 418 ILE B CG2 1 
ATOM 7500 C CD1 . ILE B 1 418 ? 93.436  92.253  106.645 1.00 33.33  ? 418 ILE B CD1 1 
ATOM 7501 N N   . CYS B 1 419 ? 98.421  93.627  105.127 1.00 14.88  ? 419 CYS B N   1 
ATOM 7502 C CA  . CYS B 1 419 ? 99.869  93.707  105.216 1.00 18.61  ? 419 CYS B CA  1 
ATOM 7503 C C   . CYS B 1 419 ? 100.238 94.003  106.659 1.00 12.11  ? 419 CYS B C   1 
ATOM 7504 O O   . CYS B 1 419 ? 99.504  94.701  107.363 1.00 23.92  ? 419 CYS B O   1 
ATOM 7505 C CB  . CYS B 1 419 ? 100.434 94.787  104.295 1.00 21.81  ? 419 CYS B CB  1 
ATOM 7506 S SG  . CYS B 1 419 ? 102.148 95.204  104.661 1.00 56.55  ? 419 CYS B SG  1 
ATOM 7507 N N   . LEU B 1 420 ? 101.366 93.466  107.104 1.00 10.78  ? 420 LEU B N   1 
ATOM 7508 C CA  . LEU B 1 420 ? 101.685 93.491  108.519 1.00 12.78  ? 420 LEU B CA  1 
ATOM 7509 C C   . LEU B 1 420 ? 103.124 93.957  108.691 1.00 23.44  ? 420 LEU B C   1 
ATOM 7510 O O   . LEU B 1 420 ? 103.981 93.690  107.847 1.00 42.05  ? 420 LEU B O   1 
ATOM 7511 C CB  . LEU B 1 420 ? 101.441 92.103  109.131 1.00 11.95  ? 420 LEU B CB  1 
ATOM 7512 C CG  . LEU B 1 420 ? 101.088 91.978  110.613 1.00 2.73   ? 420 LEU B CG  1 
ATOM 7513 C CD1 . LEU B 1 420 ? 100.706 90.549  110.938 1.00 14.39  ? 420 LEU B CD1 1 
ATOM 7514 C CD2 . LEU B 1 420 ? 102.236 92.406  111.476 1.00 0.54   ? 420 LEU B CD2 1 
ATOM 7515 N N   . ALA B 1 421 ? 103.374 94.674  109.783 1.00 12.50  ? 421 ALA B N   1 
ATOM 7516 C CA  . ALA B 1 421 ? 104.670 95.267  110.064 1.00 15.55  ? 421 ALA B CA  1 
ATOM 7517 C C   . ALA B 1 421 ? 105.163 94.849  111.443 1.00 11.78  ? 421 ALA B C   1 
ATOM 7518 O O   . ALA B 1 421 ? 104.389 94.414  112.298 1.00 0.26   ? 421 ALA B O   1 
ATOM 7519 C CB  . ALA B 1 421 ? 104.605 96.791  109.984 1.00 21.46  ? 421 ALA B CB  1 
ATOM 7520 N N   . GLY B 1 422 ? 106.468 95.002  111.652 1.00 18.56  ? 422 GLY B N   1 
ATOM 7521 C CA  . GLY B 1 422 ? 107.083 94.596  112.902 1.00 23.10  ? 422 GLY B CA  1 
ATOM 7522 C C   . GLY B 1 422 ? 108.341 95.384  113.202 1.00 39.74  ? 422 GLY B C   1 
ATOM 7523 O O   . GLY B 1 422 ? 108.900 96.065  112.337 1.00 36.56  ? 422 GLY B O   1 
ATOM 7524 N N   . ASP B 1 423 ? 108.799 95.242  114.442 0.63 38.77  ? 423 ASP B N   1 
ATOM 7525 C CA  . ASP B 1 423 ? 109.873 96.050  115.021 1.00 13.72  ? 423 ASP B CA  1 
ATOM 7526 C C   . ASP B 1 423 ? 110.811 95.113  115.777 1.00 20.09  ? 423 ASP B C   1 
ATOM 7527 O O   . ASP B 1 423 ? 110.841 93.904  115.523 1.00 24.93  ? 423 ASP B O   1 
ATOM 7528 C CB  . ASP B 1 423 ? 109.312 97.155  115.928 1.00 25.58  ? 423 ASP B CB  1 
ATOM 7529 C CG  . ASP B 1 423 ? 108.760 98.334  115.157 1.00 25.97  ? 423 ASP B CG  1 
ATOM 7530 O OD1 . ASP B 1 423 ? 108.847 98.352  113.914 1.00 33.78  ? 423 ASP B OD1 1 
ATOM 7531 O OD2 . ASP B 1 423 ? 108.228 99.255  115.806 1.00 26.96  ? 423 ASP B OD2 1 
ATOM 7532 N N   . SER B 1 424 ? 111.628 95.693  116.669 1.00 24.91  ? 424 SER B N   1 
ATOM 7533 C CA  . SER B 1 424 ? 112.537 94.910  117.507 1.00 31.99  ? 424 SER B CA  1 
ATOM 7534 C C   . SER B 1 424 ? 111.796 93.850  118.298 1.00 22.26  ? 424 SER B C   1 
ATOM 7535 O O   . SER B 1 424 ? 112.195 92.681  118.320 1.00 27.92  ? 424 SER B O   1 
ATOM 7536 C CB  . SER B 1 424 ? 113.263 95.821  118.491 1.00 25.87  ? 424 SER B CB  1 
ATOM 7537 O OG  . SER B 1 424 ? 112.507 95.958  119.679 1.00 15.44  ? 424 SER B OG  1 
ATOM 7538 N N   . ALA B 1 425 ? 110.712 94.243  118.950 1.00 16.57  ? 425 ALA B N   1 
ATOM 7539 C CA  . ALA B 1 425 ? 109.925 93.344  119.772 1.00 14.63  ? 425 ALA B CA  1 
ATOM 7540 C C   . ALA B 1 425 ? 108.678 92.840  119.068 1.00 23.30  ? 425 ALA B C   1 
ATOM 7541 O O   . ALA B 1 425 ? 108.270 91.698  119.294 1.00 14.49  ? 425 ALA B O   1 
ATOM 7542 C CB  . ALA B 1 425 ? 109.537 94.053  121.065 1.00 22.39  ? 425 ALA B CB  1 
ATOM 7543 N N   . GLY B 1 426 ? 108.084 93.656  118.203 1.00 36.54  ? 426 GLY B N   1 
ATOM 7544 C CA  . GLY B 1 426 ? 106.933 93.285  117.415 1.00 30.48  ? 426 GLY B CA  1 
ATOM 7545 C C   . GLY B 1 426 ? 107.242 92.446  116.201 1.00 24.88  ? 426 GLY B C   1 
ATOM 7546 O O   . GLY B 1 426 ? 106.330 92.096  115.449 1.00 33.77  ? 426 GLY B O   1 
ATOM 7547 N N   . GLY B 1 427 ? 108.513 92.116  115.980 1.00 15.12  ? 427 GLY B N   1 
ATOM 7548 C CA  . GLY B 1 427 ? 108.888 91.241  114.889 1.00 20.01  ? 427 GLY B CA  1 
ATOM 7549 C C   . GLY B 1 427 ? 108.538 89.785  115.090 1.00 29.05  ? 427 GLY B C   1 
ATOM 7550 O O   . GLY B 1 427 ? 108.562 89.023  114.121 1.00 34.92  ? 427 GLY B O   1 
ATOM 7551 N N   . ASN B 1 428 ? 108.236 89.373  116.322 1.00 17.82  ? 428 ASN B N   1 
ATOM 7552 C CA  . ASN B 1 428 ? 107.649 88.063  116.562 1.00 22.54  ? 428 ASN B CA  1 
ATOM 7553 C C   . ASN B 1 428 ? 106.129 88.107  116.619 1.00 42.28  ? 428 ASN B C   1 
ATOM 7554 O O   . ASN B 1 428 ? 105.493 87.050  116.563 1.00 36.78  ? 428 ASN B O   1 
ATOM 7555 C CB  . ASN B 1 428 ? 108.191 87.459  117.863 1.00 17.02  ? 428 ASN B CB  1 
ATOM 7556 C CG  . ASN B 1 428 ? 107.849 88.287  119.081 1.00 22.99  ? 428 ASN B CG  1 
ATOM 7557 O OD1 . ASN B 1 428 ? 106.751 88.190  119.625 1.00 32.29  ? 428 ASN B OD1 1 
ATOM 7558 N ND2 . ASN B 1 428 ? 108.787 89.117  119.513 1.00 27.03  ? 428 ASN B ND2 1 
ATOM 7559 N N   . LEU B 1 429 ? 105.541 89.304  116.733 1.00 36.67  ? 429 LEU B N   1 
ATOM 7560 C CA  . LEU B 1 429 ? 104.087 89.444  116.680 1.00 14.40  ? 429 LEU B CA  1 
ATOM 7561 C C   . LEU B 1 429 ? 103.540 89.136  115.301 1.00 19.46  ? 429 LEU B C   1 
ATOM 7562 O O   . LEU B 1 429 ? 102.408 88.663  115.177 1.00 26.16  ? 429 LEU B O   1 
ATOM 7563 C CB  . LEU B 1 429 ? 103.660 90.849  117.091 1.00 3.64   ? 429 LEU B CB  1 
ATOM 7564 C CG  . LEU B 1 429 ? 103.167 91.018  118.522 1.00 17.46  ? 429 LEU B CG  1 
ATOM 7565 C CD1 . LEU B 1 429 ? 101.926 90.196  118.726 1.00 27.66  ? 429 LEU B CD1 1 
ATOM 7566 C CD2 . LEU B 1 429 ? 104.212 90.563  119.464 1.00 25.67  ? 429 LEU B CD2 1 
ATOM 7567 N N   . CYS B 1 430 ? 104.313 89.404  114.258 1.00 11.72  ? 430 CYS B N   1 
ATOM 7568 C CA  . CYS B 1 430 ? 103.901 89.040  112.913 1.00 14.72  ? 430 CYS B CA  1 
ATOM 7569 C C   . CYS B 1 430 ? 104.169 87.576  112.593 1.00 29.30  ? 430 CYS B C   1 
ATOM 7570 O O   . CYS B 1 430 ? 103.984 87.166  111.444 1.00 26.95  ? 430 CYS B O   1 
ATOM 7571 C CB  . CYS B 1 430 ? 104.593 89.945  111.902 1.00 15.07  ? 430 CYS B CB  1 
ATOM 7572 S SG  . CYS B 1 430 ? 106.245 90.438  112.383 1.00 40.68  ? 430 CYS B SG  1 
ATOM 7573 N N   . PHE B 1 431 ? 104.619 86.791  113.569 1.00 40.23  ? 431 PHE B N   1 
ATOM 7574 C CA  . PHE B 1 431 ? 104.648 85.337  113.484 1.00 27.73  ? 431 PHE B CA  1 
ATOM 7575 C C   . PHE B 1 431 ? 103.749 84.667  114.507 1.00 29.39  ? 431 PHE B C   1 
ATOM 7576 O O   . PHE B 1 431 ? 103.189 83.610  114.226 1.00 31.11  ? 431 PHE B O   1 
ATOM 7577 C CB  . PHE B 1 431 ? 106.071 84.809  113.683 1.00 23.75  ? 431 PHE B CB  1 
ATOM 7578 C CG  . PHE B 1 431 ? 107.051 85.306  112.675 1.00 28.80  ? 431 PHE B CG  1 
ATOM 7579 C CD1 . PHE B 1 431 ? 106.940 84.948  111.347 1.00 27.47  ? 431 PHE B CD1 1 
ATOM 7580 C CD2 . PHE B 1 431 ? 108.099 86.116  113.064 1.00 33.56  ? 431 PHE B CD2 1 
ATOM 7581 C CE1 . PHE B 1 431 ? 107.850 85.403  110.429 1.00 20.24  ? 431 PHE B CE1 1 
ATOM 7582 C CE2 . PHE B 1 431 ? 109.011 86.575  112.147 1.00 30.17  ? 431 PHE B CE2 1 
ATOM 7583 C CZ  . PHE B 1 431 ? 108.887 86.218  110.832 1.00 22.09  ? 431 PHE B CZ  1 
ATOM 7584 N N   . THR B 1 432 ? 103.607 85.251  115.696 1.00 23.93  ? 432 THR B N   1 
ATOM 7585 C CA  . THR B 1 432 ? 102.862 84.587  116.758 1.00 28.57  ? 432 THR B CA  1 
ATOM 7586 C C   . THR B 1 432 ? 101.360 84.695  116.529 1.00 33.03  ? 432 THR B C   1 
ATOM 7587 O O   . THR B 1 432 ? 100.665 83.681  116.410 1.00 34.05  ? 432 THR B O   1 
ATOM 7588 C CB  . THR B 1 432 ? 103.249 85.176  118.111 1.00 33.20  ? 432 THR B CB  1 
ATOM 7589 O OG1 . THR B 1 432 ? 104.620 84.871  118.385 1.00 26.27  ? 432 THR B OG1 1 
ATOM 7590 C CG2 . THR B 1 432 ? 102.386 84.587  119.201 1.00 40.78  ? 432 THR B CG2 1 
ATOM 7591 N N   . VAL B 1 433 ? 100.836 85.923  116.460 1.00 35.11  ? 433 VAL B N   1 
ATOM 7592 C CA  . VAL B 1 433 ? 99.400  86.106  116.259 1.00 39.21  ? 433 VAL B CA  1 
ATOM 7593 C C   . VAL B 1 433 ? 99.003  86.126  114.793 1.00 45.27  ? 433 VAL B C   1 
ATOM 7594 O O   . VAL B 1 433 ? 97.807  86.044  114.488 1.00 36.69  ? 433 VAL B O   1 
ATOM 7595 C CB  . VAL B 1 433 ? 98.895  87.397  116.931 1.00 24.78  ? 433 VAL B CB  1 
ATOM 7596 C CG1 . VAL B 1 433 ? 99.450  87.512  118.333 1.00 35.59  ? 433 VAL B CG1 1 
ATOM 7597 C CG2 . VAL B 1 433 ? 99.253  88.620  116.103 1.00 34.20  ? 433 VAL B CG2 1 
ATOM 7598 N N   . ALA B 1 434 ? 99.959  86.233  113.876 1.00 37.32  ? 434 ALA B N   1 
ATOM 7599 C CA  . ALA B 1 434 ? 99.644  86.174  112.458 1.00 38.66  ? 434 ALA B CA  1 
ATOM 7600 C C   . ALA B 1 434 ? 99.517  84.751  111.945 1.00 39.01  ? 434 ALA B C   1 
ATOM 7601 O O   . ALA B 1 434 ? 98.995  84.545  110.845 1.00 37.01  ? 434 ALA B O   1 
ATOM 7602 C CB  . ALA B 1 434 ? 100.707 86.912  111.645 1.00 34.65  ? 434 ALA B CB  1 
ATOM 7603 N N   . LEU B 1 435 ? 99.980  83.774  112.712 1.00 35.63  ? 435 LEU B N   1 
ATOM 7604 C CA  . LEU B 1 435 ? 99.899  82.374  112.333 1.00 35.85  ? 435 LEU B CA  1 
ATOM 7605 C C   . LEU B 1 435 ? 98.935  81.588  113.203 1.00 42.11  ? 435 LEU B C   1 
ATOM 7606 O O   . LEU B 1 435 ? 98.373  80.588  112.746 1.00 43.83  ? 435 LEU B O   1 
ATOM 7607 C CB  . LEU B 1 435 ? 101.295 81.758  112.398 1.00 41.82  ? 435 LEU B CB  1 
ATOM 7608 C CG  . LEU B 1 435 ? 101.584 80.269  112.444 1.00 41.05  ? 435 LEU B CG  1 
ATOM 7609 C CD1 . LEU B 1 435 ? 101.432 79.618  111.080 1.00 45.82  ? 435 LEU B CD1 1 
ATOM 7610 C CD2 . LEU B 1 435 ? 102.992 80.149  112.975 1.00 42.31  ? 435 LEU B CD2 1 
ATOM 7611 N N   . ARG B 1 436 ? 98.706  82.040  114.437 1.00 53.07  ? 436 ARG B N   1 
ATOM 7612 C CA  . ARG B 1 436 ? 97.687  81.437  115.285 1.00 57.73  ? 436 ARG B CA  1 
ATOM 7613 C C   . ARG B 1 436 ? 96.276  81.682  114.769 1.00 47.28  ? 436 ARG B C   1 
ATOM 7614 O O   . ARG B 1 436 ? 95.354  80.967  115.175 1.00 46.97  ? 436 ARG B O   1 
ATOM 7615 C CB  . ARG B 1 436 ? 97.824  81.952  116.719 1.00 50.68  ? 436 ARG B CB  1 
ATOM 7616 C CG  . ARG B 1 436 ? 97.583  83.439  116.897 1.00 44.26  ? 436 ARG B CG  1 
ATOM 7617 C CD  . ARG B 1 436 ? 97.526  83.799  118.372 1.00 49.60  ? 436 ARG B CD  1 
ATOM 7618 N NE  . ARG B 1 436 ? 96.823  82.800  119.174 1.00 41.36  ? 436 ARG B NE  1 
ATOM 7619 C CZ  . ARG B 1 436 ? 95.560  82.418  119.010 1.00 42.35  ? 436 ARG B CZ  1 
ATOM 7620 N NH1 . ARG B 1 436 ? 94.770  82.986  118.114 1.00 49.51  ? 436 ARG B NH1 1 
ATOM 7621 N NH2 . ARG B 1 436 ? 95.073  81.448  119.778 1.00 49.32  ? 436 ARG B NH2 1 
ATOM 7622 N N   . ALA B 1 437 ? 96.091  82.663  113.885 1.00 54.30  ? 437 ALA B N   1 
ATOM 7623 C CA  . ALA B 1 437 ? 94.810  82.823  113.213 1.00 62.93  ? 437 ALA B CA  1 
ATOM 7624 C C   . ALA B 1 437 ? 94.501  81.630  112.319 1.00 58.51  ? 437 ALA B C   1 
ATOM 7625 O O   . ALA B 1 437 ? 93.335  81.234  112.199 1.00 59.57  ? 437 ALA B O   1 
ATOM 7626 C CB  . ALA B 1 437 ? 94.805  84.119  112.404 1.00 65.72  ? 437 ALA B CB  1 
ATOM 7627 N N   . ALA B 1 438 ? 95.527  81.040  111.694 1.00 50.87  ? 438 ALA B N   1 
ATOM 7628 C CA  . ALA B 1 438 ? 95.336  79.830  110.901 1.00 54.50  ? 438 ALA B CA  1 
ATOM 7629 C C   . ALA B 1 438 ? 94.959  78.630  111.757 1.00 61.14  ? 438 ALA B C   1 
ATOM 7630 O O   . ALA B 1 438 ? 94.401  77.662  111.231 1.00 71.11  ? 438 ALA B O   1 
ATOM 7631 C CB  . ALA B 1 438 ? 96.599  79.514  110.100 1.00 58.39  ? 438 ALA B CB  1 
ATOM 7632 N N   . ALA B 1 439 ? 95.263  78.662  113.057 1.00 56.49  ? 439 ALA B N   1 
ATOM 7633 C CA  . ALA B 1 439 ? 94.761  77.627  113.952 1.00 61.62  ? 439 ALA B CA  1 
ATOM 7634 C C   . ALA B 1 439 ? 93.265  77.779  114.196 1.00 63.27  ? 439 ALA B C   1 
ATOM 7635 O O   . ALA B 1 439 ? 92.588  76.796  114.515 1.00 60.50  ? 439 ALA B O   1 
ATOM 7636 C CB  . ALA B 1 439 ? 95.522  77.658  115.277 1.00 60.65  ? 439 ALA B CB  1 
ATOM 7637 N N   . TYR B 1 440 ? 92.736  78.993  114.054 1.00 70.18  ? 440 TYR B N   1 
ATOM 7638 C CA  . TYR B 1 440 ? 91.317  79.262  114.248 1.00 64.39  ? 440 TYR B CA  1 
ATOM 7639 C C   . TYR B 1 440 ? 90.506  79.145  112.965 1.00 66.88  ? 440 TYR B C   1 
ATOM 7640 O O   . TYR B 1 440 ? 89.276  79.216  113.023 1.00 67.14  ? 440 TYR B O   1 
ATOM 7641 C CB  . TYR B 1 440 ? 91.123  80.657  114.852 1.00 65.96  ? 440 TYR B CB  1 
ATOM 7642 C CG  . TYR B 1 440 ? 91.221  80.699  116.363 1.00 69.20  ? 440 TYR B CG  1 
ATOM 7643 C CD1 . TYR B 1 440 ? 91.797  79.653  117.074 1.00 74.05  ? 440 TYR B CD1 1 
ATOM 7644 C CD2 . TYR B 1 440 ? 90.744  81.790  117.077 1.00 63.59  ? 440 TYR B CD2 1 
ATOM 7645 C CE1 . TYR B 1 440 ? 91.886  79.689  118.452 1.00 72.49  ? 440 TYR B CE1 1 
ATOM 7646 C CE2 . TYR B 1 440 ? 90.830  81.835  118.455 1.00 63.83  ? 440 TYR B CE2 1 
ATOM 7647 C CZ  . TYR B 1 440 ? 91.405  80.784  119.136 1.00 67.94  ? 440 TYR B CZ  1 
ATOM 7648 O OH  . TYR B 1 440 ? 91.495  80.825  120.507 1.00 66.59  ? 440 TYR B OH  1 
ATOM 7649 N N   . GLY B 1 441 ? 91.158  78.971  111.816 1.00 70.32  ? 441 GLY B N   1 
ATOM 7650 C CA  . GLY B 1 441 ? 90.472  78.801  110.553 1.00 75.26  ? 441 GLY B CA  1 
ATOM 7651 C C   . GLY B 1 441 ? 90.157  80.081  109.808 1.00 76.26  ? 441 GLY B C   1 
ATOM 7652 O O   . GLY B 1 441 ? 89.742  80.014  108.643 1.00 81.59  ? 441 GLY B O   1 
ATOM 7653 N N   . VAL B 1 442 ? 90.341  81.243  110.436 1.00 83.02  ? 442 VAL B N   1 
ATOM 7654 C CA  . VAL B 1 442 ? 90.099  82.512  109.764 1.00 77.70  ? 442 VAL B CA  1 
ATOM 7655 C C   . VAL B 1 442 ? 91.255  82.791  108.805 1.00 77.07  ? 442 VAL B C   1 
ATOM 7656 O O   . VAL B 1 442 ? 92.352  82.233  108.943 1.00 82.48  ? 442 VAL B O   1 
ATOM 7657 C CB  . VAL B 1 442 ? 89.922  83.625  110.819 1.00 79.20  ? 442 VAL B CB  1 
ATOM 7658 C CG1 . VAL B 1 442 ? 91.213  83.863  111.583 1.00 78.15  ? 442 VAL B CG1 1 
ATOM 7659 C CG2 . VAL B 1 442 ? 89.344  84.919  110.232 1.00 82.24  ? 442 VAL B CG2 1 
ATOM 7660 N N   . ARG B 1 443 ? 90.999  83.624  107.796 1.00 68.26  ? 443 ARG B N   1 
ATOM 7661 C CA  . ARG B 1 443 ? 92.014  83.933  106.796 1.00 73.14  ? 443 ARG B CA  1 
ATOM 7662 C C   . ARG B 1 443 ? 93.187  84.682  107.419 1.00 76.27  ? 443 ARG B C   1 
ATOM 7663 O O   . ARG B 1 443 ? 93.028  85.445  108.376 1.00 73.72  ? 443 ARG B O   1 
ATOM 7664 C CB  . ARG B 1 443 ? 91.401  84.747  105.653 1.00 74.43  ? 443 ARG B CB  1 
ATOM 7665 C CG  . ARG B 1 443 ? 90.855  86.108  106.054 1.00 72.94  ? 443 ARG B CG  1 
ATOM 7666 C CD  . ARG B 1 443 ? 89.799  86.590  105.070 1.00 75.55  ? 443 ARG B CD  1 
ATOM 7667 N NE  . ARG B 1 443 ? 88.477  86.062  105.384 1.00 78.24  ? 443 ARG B NE  1 
ATOM 7668 C CZ  . ARG B 1 443 ? 87.834  85.162  104.652 1.00 74.87  ? 443 ARG B CZ  1 
ATOM 7669 N NH1 . ARG B 1 443 ? 88.366  84.662  103.549 1.00 71.43  ? 443 ARG B NH1 1 
ATOM 7670 N NH2 . ARG B 1 443 ? 86.629  84.753  105.037 1.00 74.21  ? 443 ARG B NH2 1 
ATOM 7671 N N   . VAL B 1 444 ? 94.376  84.439  106.875 1.00 62.53  ? 444 VAL B N   1 
ATOM 7672 C CA  . VAL B 1 444 ? 95.632  84.956  107.412 1.00 54.55  ? 444 VAL B CA  1 
ATOM 7673 C C   . VAL B 1 444 ? 96.151  86.038  106.471 1.00 52.43  ? 444 VAL B C   1 
ATOM 7674 O O   . VAL B 1 444 ? 95.739  86.071  105.302 1.00 51.76  ? 444 VAL B O   1 
ATOM 7675 C CB  . VAL B 1 444 ? 96.652  83.820  107.594 1.00 54.80  ? 444 VAL B CB  1 
ATOM 7676 C CG1 . VAL B 1 444 ? 96.271  82.958  108.782 1.00 50.87  ? 444 VAL B CG1 1 
ATOM 7677 C CG2 . VAL B 1 444 ? 96.744  82.986  106.326 1.00 60.84  ? 444 VAL B CG2 1 
ATOM 7678 N N   . PRO B 1 445 ? 97.019  86.952  106.923 1.00 46.01  ? 445 PRO B N   1 
ATOM 7679 C CA  . PRO B 1 445 ? 97.581  87.944  106.001 1.00 42.24  ? 445 PRO B CA  1 
ATOM 7680 C C   . PRO B 1 445 ? 98.449  87.285  104.942 1.00 47.85  ? 445 PRO B C   1 
ATOM 7681 O O   . PRO B 1 445 ? 98.982  86.193  105.138 1.00 45.41  ? 445 PRO B O   1 
ATOM 7682 C CB  . PRO B 1 445 ? 98.409  88.854  106.916 1.00 36.17  ? 445 PRO B CB  1 
ATOM 7683 C CG  . PRO B 1 445 ? 98.652  88.053  108.138 1.00 37.29  ? 445 PRO B CG  1 
ATOM 7684 C CD  . PRO B 1 445 ? 97.433  87.219  108.311 1.00 45.62  ? 445 PRO B CD  1 
ATOM 7685 N N   . ASP B 1 446 ? 98.567  87.953  103.796 1.00 45.26  ? 446 ASP B N   1 
ATOM 7686 C CA  . ASP B 1 446 ? 99.319  87.424  102.668 1.00 44.05  ? 446 ASP B CA  1 
ATOM 7687 C C   . ASP B 1 446 ? 100.755 87.932  102.636 1.00 38.97  ? 446 ASP B C   1 
ATOM 7688 O O   . ASP B 1 446 ? 101.381 87.936  101.572 1.00 44.05  ? 446 ASP B O   1 
ATOM 7689 C CB  . ASP B 1 446 ? 98.610  87.757  101.356 1.00 50.41  ? 446 ASP B CB  1 
ATOM 7690 C CG  . ASP B 1 446 ? 98.599  89.237  101.063 1.00 50.71  ? 446 ASP B CG  1 
ATOM 7691 O OD1 . ASP B 1 446 ? 98.564  90.029  102.025 1.00 43.52  ? 446 ASP B OD1 1 
ATOM 7692 O OD2 . ASP B 1 446 ? 98.629  89.609  99.871  1.00 51.90  ? 446 ASP B OD2 1 
ATOM 7693 N N   . GLY B 1 447 ? 101.287 88.361  103.776 1.00 34.85  ? 447 GLY B N   1 
ATOM 7694 C CA  . GLY B 1 447 ? 102.665 88.799  103.826 1.00 44.02  ? 447 GLY B CA  1 
ATOM 7695 C C   . GLY B 1 447 ? 103.073 89.390  105.157 1.00 45.54  ? 447 GLY B C   1 
ATOM 7696 O O   . GLY B 1 447 ? 102.279 90.061  105.820 1.00 43.40  ? 447 GLY B O   1 
ATOM 7697 N N   . ILE B 1 448 ? 104.321 89.153  105.544 1.00 46.97  ? 448 ILE B N   1 
ATOM 7698 C CA  . ILE B 1 448 ? 104.865 89.585  106.824 1.00 36.21  ? 448 ILE B CA  1 
ATOM 7699 C C   . ILE B 1 448 ? 106.113 90.413  106.559 1.00 30.83  ? 448 ILE B C   1 
ATOM 7700 O O   . ILE B 1 448 ? 107.003 89.978  105.820 1.00 35.73  ? 448 ILE B O   1 
ATOM 7701 C CB  . ILE B 1 448 ? 105.194 88.378  107.722 1.00 41.70  ? 448 ILE B CB  1 
ATOM 7702 C CG1 . ILE B 1 448 ? 103.922 87.703  108.237 1.00 36.75  ? 448 ILE B CG1 1 
ATOM 7703 C CG2 . ILE B 1 448 ? 106.098 88.784  108.867 1.00 33.84  ? 448 ILE B CG2 1 
ATOM 7704 C CD1 . ILE B 1 448 ? 102.853 88.650  108.703 1.00 40.31  ? 448 ILE B CD1 1 
ATOM 7705 N N   . MET B 1 449 ? 106.178 91.600  107.151 1.00 12.75  ? 449 MET B N   1 
ATOM 7706 C CA  . MET B 1 449 ? 107.401 92.388  107.183 1.00 22.83  ? 449 MET B CA  1 
ATOM 7707 C C   . MET B 1 449 ? 107.831 92.535  108.634 1.00 32.70  ? 449 MET B C   1 
ATOM 7708 O O   . MET B 1 449 ? 107.056 93.010  109.468 1.00 28.02  ? 449 MET B O   1 
ATOM 7709 C CB  . MET B 1 449 ? 107.197 93.760  106.538 1.00 20.31  ? 449 MET B CB  1 
ATOM 7710 C CG  . MET B 1 449 ? 108.415 94.297  105.799 1.00 32.92  ? 449 MET B CG  1 
ATOM 7711 S SD  . MET B 1 449 ? 109.795 94.747  106.866 1.00 33.15  ? 449 MET B SD  1 
ATOM 7712 C CE  . MET B 1 449 ? 108.989 95.853  108.016 1.00 36.53  ? 449 MET B CE  1 
ATOM 7713 N N   . ALA B 1 450 ? 109.060 92.122  108.933 1.00 35.48  ? 450 ALA B N   1 
ATOM 7714 C CA  . ALA B 1 450 ? 109.573 92.147  110.299 1.00 23.70  ? 450 ALA B CA  1 
ATOM 7715 C C   . ALA B 1 450 ? 110.992 92.686  110.264 1.00 27.95  ? 450 ALA B C   1 
ATOM 7716 O O   . ALA B 1 450 ? 111.902 92.007  109.781 1.00 28.91  ? 450 ALA B O   1 
ATOM 7717 C CB  . ALA B 1 450 ? 109.542 90.759  110.934 1.00 25.12  ? 450 ALA B CB  1 
ATOM 7718 N N   . ALA B 1 451 ? 111.185 93.891  110.781 1.00 23.92  ? 451 ALA B N   1 
ATOM 7719 C CA  . ALA B 1 451 ? 112.519 94.460  110.875 1.00 27.44  ? 451 ALA B CA  1 
ATOM 7720 C C   . ALA B 1 451 ? 113.182 93.959  112.148 1.00 28.05  ? 451 ALA B C   1 
ATOM 7721 O O   . ALA B 1 451 ? 112.709 94.258  113.250 1.00 31.87  ? 451 ALA B O   1 
ATOM 7722 C CB  . ALA B 1 451 ? 112.457 95.984  110.864 1.00 27.57  ? 451 ALA B CB  1 
ATOM 7723 N N   . TYR B 1 452 ? 114.312 93.248  111.985 1.00 21.64  ? 452 TYR B N   1 
ATOM 7724 C CA  . TYR B 1 452 ? 115.172 92.631  113.000 1.00 25.67  ? 452 TYR B CA  1 
ATOM 7725 C C   . TYR B 1 452 ? 114.354 92.003  114.130 1.00 32.48  ? 452 TYR B C   1 
ATOM 7726 O O   . TYR B 1 452 ? 114.325 92.519  115.254 1.00 32.05  ? 452 TYR B O   1 
ATOM 7727 C CB  . TYR B 1 452 ? 116.228 93.636  113.512 1.00 26.47  ? 452 TYR B CB  1 
ATOM 7728 C CG  . TYR B 1 452 ? 115.749 94.988  114.024 1.00 15.51  ? 452 TYR B CG  1 
ATOM 7729 C CD1 . TYR B 1 452 ? 115.415 96.017  113.145 1.00 25.15  ? 452 TYR B CD1 1 
ATOM 7730 C CD2 . TYR B 1 452 ? 115.715 95.263  115.382 1.00 15.22  ? 452 TYR B CD2 1 
ATOM 7731 C CE1 . TYR B 1 452 ? 114.980 97.234  113.601 1.00 27.81  ? 452 TYR B CE1 1 
ATOM 7732 C CE2 . TYR B 1 452 ? 115.304 96.490  115.843 1.00 21.54  ? 452 TYR B CE2 1 
ATOM 7733 C CZ  . TYR B 1 452 ? 114.933 97.469  114.951 1.00 26.11  ? 452 TYR B CZ  1 
ATOM 7734 O OH  . TYR B 1 452 ? 114.506 98.694  115.398 1.00 15.34  ? 452 TYR B OH  1 
ATOM 7735 N N   . PRO B 1 453 ? 113.659 90.899  113.857 1.00 25.67  ? 453 PRO B N   1 
ATOM 7736 C CA  . PRO B 1 453 ? 112.738 90.336  114.850 1.00 15.29  ? 453 PRO B CA  1 
ATOM 7737 C C   . PRO B 1 453 ? 113.459 89.646  115.996 1.00 13.15  ? 453 PRO B C   1 
ATOM 7738 O O   . PRO B 1 453 ? 114.580 89.156  115.853 1.00 27.22  ? 453 PRO B O   1 
ATOM 7739 C CB  . PRO B 1 453 ? 111.925 89.330  114.034 1.00 22.60  ? 453 PRO B CB  1 
ATOM 7740 C CG  . PRO B 1 453 ? 112.867 88.895  112.969 1.00 17.29  ? 453 PRO B CG  1 
ATOM 7741 C CD  . PRO B 1 453 ? 113.698 90.092  112.625 1.00 18.81  ? 453 PRO B CD  1 
ATOM 7742 N N   . ALA B 1 454 ? 112.786 89.601  117.146 1.00 12.76  ? 454 ALA B N   1 
ATOM 7743 C CA  . ALA B 1 454 ? 113.291 88.905  118.330 1.00 29.35  ? 454 ALA B CA  1 
ATOM 7744 C C   . ALA B 1 454 ? 112.561 87.570  118.440 1.00 44.74  ? 454 ALA B C   1 
ATOM 7745 O O   . ALA B 1 454 ? 111.593 87.414  119.183 1.00 45.84  ? 454 ALA B O   1 
ATOM 7746 C CB  . ALA B 1 454 ? 113.104 89.760  119.577 1.00 22.98  ? 454 ALA B CB  1 
ATOM 7747 N N   . THR B 1 455 ? 113.061 86.584  117.698 1.00 42.34  ? 455 THR B N   1 
ATOM 7748 C CA  . THR B 1 455 ? 112.321 85.360  117.425 1.00 31.45  ? 455 THR B CA  1 
ATOM 7749 C C   . THR B 1 455 ? 112.843 84.170  118.234 1.00 39.00  ? 455 THR B C   1 
ATOM 7750 O O   . THR B 1 455 ? 112.337 83.053  118.091 1.00 47.92  ? 455 THR B O   1 
ATOM 7751 C CB  . THR B 1 455 ? 112.383 85.081  115.920 1.00 29.12  ? 455 THR B CB  1 
ATOM 7752 O OG1 . THR B 1 455 ? 112.287 86.325  115.224 1.00 36.48  ? 455 THR B OG1 1 
ATOM 7753 C CG2 . THR B 1 455 ? 111.183 84.292  115.469 1.00 39.00  ? 455 THR B CG2 1 
ATOM 7754 N N   . MET B 1 456 ? 113.830 84.385  119.103 1.00 43.60  ? 456 MET B N   1 
ATOM 7755 C CA  . MET B 1 456 ? 114.446 83.315  119.889 1.00 49.95  ? 456 MET B CA  1 
ATOM 7756 C C   . MET B 1 456 ? 114.534 83.724  121.356 1.00 54.53  ? 456 MET B C   1 
ATOM 7757 O O   . MET B 1 456 ? 115.602 83.714  121.967 1.00 50.94  ? 456 MET B O   1 
ATOM 7758 C CB  . MET B 1 456 ? 115.816 82.922  119.356 1.00 51.64  ? 456 MET B CB  1 
ATOM 7759 C CG  . MET B 1 456 ? 115.747 81.870  118.278 1.00 49.00  ? 456 MET B CG  1 
ATOM 7760 S SD  . MET B 1 456 ? 114.486 80.667  118.707 1.00 38.98  ? 456 MET B SD  1 
ATOM 7761 C CE  . MET B 1 456 ? 115.391 79.588  119.808 1.00 46.89  ? 456 MET B CE  1 
ATOM 7762 N N   . LEU B 1 457 ? 113.385 84.102  121.921 1.00 58.98  ? 457 LEU B N   1 
ATOM 7763 C CA  . LEU B 1 457 ? 113.327 84.592  123.294 1.00 58.28  ? 457 LEU B CA  1 
ATOM 7764 C C   . LEU B 1 457 ? 113.754 83.549  124.326 1.00 58.89  ? 457 LEU B C   1 
ATOM 7765 O O   . LEU B 1 457 ? 114.001 83.911  125.480 1.00 59.83  ? 457 LEU B O   1 
ATOM 7766 C CB  . LEU B 1 457 ? 111.914 85.084  123.601 1.00 59.76  ? 457 LEU B CB  1 
ATOM 7767 C CG  . LEU B 1 457 ? 111.565 86.468  123.050 1.00 61.59  ? 457 LEU B CG  1 
ATOM 7768 C CD1 . LEU B 1 457 ? 110.070 86.586  122.804 1.00 50.78  ? 457 LEU B CD1 1 
ATOM 7769 C CD2 . LEU B 1 457 ? 112.049 87.567  123.988 1.00 62.62  ? 457 LEU B CD2 1 
ATOM 7770 N N   . GLN B 1 458 ? 113.833 82.275  123.949 1.00 70.67  ? 458 GLN B N   1 
ATOM 7771 C CA  . GLN B 1 458 ? 114.378 81.259  124.841 1.00 76.15  ? 458 GLN B CA  1 
ATOM 7772 C C   . GLN B 1 458 ? 115.853 81.546  125.116 1.00 75.46  ? 458 GLN B C   1 
ATOM 7773 O O   . GLN B 1 458 ? 116.633 81.714  124.168 1.00 68.67  ? 458 GLN B O   1 
ATOM 7774 C CB  . GLN B 1 458 ? 114.212 79.871  124.225 1.00 70.56  ? 458 GLN B CB  1 
ATOM 7775 C CG  . GLN B 1 458 ? 114.763 78.739  125.068 1.00 71.32  ? 458 GLN B CG  1 
ATOM 7776 C CD  . GLN B 1 458 ? 115.184 77.551  124.234 1.00 76.56  ? 458 GLN B CD  1 
ATOM 7777 O OE1 . GLN B 1 458 ? 115.361 76.447  124.748 1.00 80.27  ? 458 GLN B OE1 1 
ATOM 7778 N NE2 . GLN B 1 458 ? 115.348 77.770  122.935 1.00 75.20  ? 458 GLN B NE2 1 
ATOM 7779 N N   . PRO B 1 459 ? 116.276 81.609  126.387 1.00 89.30  ? 459 PRO B N   1 
ATOM 7780 C CA  . PRO B 1 459 ? 117.620 82.105  126.719 1.00 88.04  ? 459 PRO B CA  1 
ATOM 7781 C C   . PRO B 1 459 ? 118.695 81.055  126.482 1.00 88.94  ? 459 PRO B C   1 
ATOM 7782 O O   . PRO B 1 459 ? 118.783 80.058  127.206 1.00 87.61  ? 459 PRO B O   1 
ATOM 7783 C CB  . PRO B 1 459 ? 117.497 82.469  128.208 1.00 89.11  ? 459 PRO B CB  1 
ATOM 7784 C CG  . PRO B 1 459 ? 116.026 82.332  128.552 1.00 89.93  ? 459 PRO B CG  1 
ATOM 7785 C CD  . PRO B 1 459 ? 115.500 81.316  127.601 1.00 90.63  ? 459 PRO B CD  1 
ATOM 7786 N N   . ALA B 1 460 ? 119.528 81.289  125.471 1.00 90.24  ? 460 ALA B N   1 
ATOM 7787 C CA  . ALA B 1 460 ? 120.719 80.486  125.230 1.00 88.69  ? 460 ALA B CA  1 
ATOM 7788 C C   . ALA B 1 460 ? 121.689 81.306  124.393 1.00 86.63  ? 460 ALA B C   1 
ATOM 7789 O O   . ALA B 1 460 ? 121.289 82.251  123.708 1.00 85.97  ? 460 ALA B O   1 
ATOM 7790 C CB  . ALA B 1 460 ? 120.389 79.163  124.533 1.00 89.44  ? 460 ALA B CB  1 
ATOM 7791 N N   . ALA B 1 461 ? 122.964 80.934  124.453 1.00 84.37  ? 461 ALA B N   1 
ATOM 7792 C CA  . ALA B 1 461 ? 124.008 81.735  123.831 1.00 82.10  ? 461 ALA B CA  1 
ATOM 7793 C C   . ALA B 1 461 ? 124.278 81.293  122.398 1.00 80.22  ? 461 ALA B C   1 
ATOM 7794 O O   . ALA B 1 461 ? 124.041 80.143  122.018 1.00 82.59  ? 461 ALA B O   1 
ATOM 7795 C CB  . ALA B 1 461 ? 125.296 81.661  124.646 1.00 81.75  ? 461 ALA B CB  1 
ATOM 7796 N N   . SER B 1 462 ? 124.780 82.232  121.604 1.00 58.30  ? 462 SER B N   1 
ATOM 7797 C CA  . SER B 1 462 ? 125.078 82.022  120.195 1.00 62.36  ? 462 SER B CA  1 
ATOM 7798 C C   . SER B 1 462 ? 126.217 82.953  119.811 1.00 68.06  ? 462 SER B C   1 
ATOM 7799 O O   . SER B 1 462 ? 126.517 83.901  120.547 1.00 64.02  ? 462 SER B O   1 
ATOM 7800 C CB  . SER B 1 462 ? 123.845 82.281  119.317 1.00 64.17  ? 462 SER B CB  1 
ATOM 7801 O OG  . SER B 1 462 ? 122.687 81.662  119.843 1.00 77.17  ? 462 SER B OG  1 
ATOM 7802 N N   . PRO B 1 463 ? 126.893 82.695  118.683 1.00 64.43  ? 463 PRO B N   1 
ATOM 7803 C CA  . PRO B 1 463 ? 127.970 83.602  118.245 1.00 56.61  ? 463 PRO B CA  1 
ATOM 7804 C C   . PRO B 1 463 ? 127.536 85.038  117.972 1.00 60.41  ? 463 PRO B C   1 
ATOM 7805 O O   . PRO B 1 463 ? 128.385 85.934  118.029 1.00 65.01  ? 463 PRO B O   1 
ATOM 7806 C CB  . PRO B 1 463 ? 128.494 82.936  116.963 1.00 50.32  ? 463 PRO B CB  1 
ATOM 7807 C CG  . PRO B 1 463 ? 127.650 81.706  116.750 1.00 58.61  ? 463 PRO B CG  1 
ATOM 7808 C CD  . PRO B 1 463 ? 127.032 81.375  118.052 1.00 59.90  ? 463 PRO B CD  1 
ATOM 7809 N N   . SER B 1 464 ? 126.265 85.295  117.655 1.00 51.72  ? 464 SER B N   1 
ATOM 7810 C CA  . SER B 1 464 ? 125.786 86.671  117.584 1.00 46.02  ? 464 SER B CA  1 
ATOM 7811 C C   . SER B 1 464 ? 125.262 87.184  118.913 1.00 46.19  ? 464 SER B C   1 
ATOM 7812 O O   . SER B 1 464 ? 125.237 88.400  119.119 1.00 60.72  ? 464 SER B O   1 
ATOM 7813 C CB  . SER B 1 464 ? 124.681 86.825  116.536 1.00 55.85  ? 464 SER B CB  1 
ATOM 7814 O OG  . SER B 1 464 ? 125.202 86.958  115.228 1.00 55.83  ? 464 SER B OG  1 
ATOM 7815 N N   . ARG B 1 465 ? 124.841 86.297  119.813 1.00 44.75  ? 465 ARG B N   1 
ATOM 7816 C CA  . ARG B 1 465 ? 124.606 86.711  121.188 1.00 49.76  ? 465 ARG B CA  1 
ATOM 7817 C C   . ARG B 1 465 ? 125.906 86.909  121.951 1.00 53.96  ? 465 ARG B C   1 
ATOM 7818 O O   . ARG B 1 465 ? 125.869 87.374  123.095 1.00 61.82  ? 465 ARG B O   1 
ATOM 7819 C CB  . ARG B 1 465 ? 123.725 85.692  121.912 1.00 59.92  ? 465 ARG B CB  1 
ATOM 7820 C CG  . ARG B 1 465 ? 122.548 85.184  121.094 1.00 60.38  ? 465 ARG B CG  1 
ATOM 7821 C CD  . ARG B 1 465 ? 121.362 86.133  121.178 1.00 56.50  ? 465 ARG B CD  1 
ATOM 7822 N NE  . ARG B 1 465 ? 121.008 86.451  122.557 1.00 58.91  ? 465 ARG B NE  1 
ATOM 7823 C CZ  . ARG B 1 465 ? 120.345 85.641  123.371 1.00 58.46  ? 465 ARG B CZ  1 
ATOM 7824 N NH1 . ARG B 1 465 ? 119.888 84.470  122.961 1.00 52.76  ? 465 ARG B NH1 1 
ATOM 7825 N NH2 . ARG B 1 465 ? 120.128 86.020  124.627 1.00 60.56  ? 465 ARG B NH2 1 
ATOM 7826 N N   . LEU B 1 466 ? 127.042 86.545  121.348 1.00 50.40  ? 466 LEU B N   1 
ATOM 7827 C CA  . LEU B 1 466 ? 128.342 86.805  121.954 1.00 51.68  ? 466 LEU B CA  1 
ATOM 7828 C C   . LEU B 1 466 ? 128.595 88.302  122.075 1.00 51.65  ? 466 LEU B C   1 
ATOM 7829 O O   . LEU B 1 466 ? 128.974 88.794  123.142 1.00 50.62  ? 466 LEU B O   1 
ATOM 7830 C CB  . LEU B 1 466 ? 129.443 86.149  121.121 1.00 50.63  ? 466 LEU B CB  1 
ATOM 7831 C CG  . LEU B 1 466 ? 130.529 85.300  121.781 1.00 45.83  ? 466 LEU B CG  1 
ATOM 7832 C CD1 . LEU B 1 466 ? 129.941 84.294  122.751 1.00 48.41  ? 466 LEU B CD1 1 
ATOM 7833 C CD2 . LEU B 1 466 ? 131.334 84.598  120.712 1.00 51.74  ? 466 LEU B CD2 1 
ATOM 7834 N N   . LEU B 1 467 ? 128.375 89.045  120.996 1.00 38.48  ? 467 LEU B N   1 
ATOM 7835 C CA  . LEU B 1 467 ? 128.632 90.483  120.989 1.00 31.60  ? 467 LEU B CA  1 
ATOM 7836 C C   . LEU B 1 467 ? 127.420 91.290  121.443 1.00 33.22  ? 467 LEU B C   1 
ATOM 7837 O O   . LEU B 1 467 ? 127.100 92.355  120.927 1.00 31.24  ? 467 LEU B O   1 
ATOM 7838 C CB  . LEU B 1 467 ? 129.111 90.885  119.599 1.00 41.70  ? 467 LEU B CB  1 
ATOM 7839 C CG  . LEU B 1 467 ? 128.257 90.640  118.346 1.00 33.20  ? 467 LEU B CG  1 
ATOM 7840 C CD1 . LEU B 1 467 ? 127.393 91.800  117.863 1.00 36.76  ? 467 LEU B CD1 1 
ATOM 7841 C CD2 . LEU B 1 467 ? 129.174 90.159  117.253 1.00 34.37  ? 467 LEU B CD2 1 
ATOM 7842 N N   . SER B 1 468 ? 126.800 90.819  122.517 1.00 45.74  ? 468 SER B N   1 
ATOM 7843 C CA  . SER B 1 468 ? 125.739 91.549  123.182 1.00 49.28  ? 468 SER B CA  1 
ATOM 7844 C C   . SER B 1 468 ? 126.256 92.323  124.380 1.00 55.36  ? 468 SER B C   1 
ATOM 7845 O O   . SER B 1 468 ? 125.506 93.102  124.966 1.00 55.76  ? 468 SER B O   1 
ATOM 7846 C CB  . SER B 1 468 ? 124.628 90.588  123.615 1.00 55.61  ? 468 SER B CB  1 
ATOM 7847 O OG  . SER B 1 468 ? 123.415 91.278  123.853 1.00 61.27  ? 468 SER B OG  1 
ATOM 7848 N N   . LEU B 1 469 ? 127.520 92.128  124.750 1.00 61.00  ? 469 LEU B N   1 
ATOM 7849 C CA  . LEU B 1 469 ? 128.148 92.863  125.838 1.00 60.46  ? 469 LEU B CA  1 
ATOM 7850 C C   . LEU B 1 469 ? 128.908 94.095  125.367 1.00 52.15  ? 469 LEU B C   1 
ATOM 7851 O O   . LEU B 1 469 ? 129.385 94.864  126.206 1.00 49.58  ? 469 LEU B O   1 
ATOM 7852 C CB  . LEU B 1 469 ? 129.098 91.941  126.618 1.00 60.11  ? 469 LEU B CB  1 
ATOM 7853 C CG  . LEU B 1 469 ? 130.561 91.806  126.179 1.00 53.94  ? 469 LEU B CG  1 
ATOM 7854 C CD1 . LEU B 1 469 ? 131.360 91.086  127.251 1.00 51.65  ? 469 LEU B CD1 1 
ATOM 7855 C CD2 . LEU B 1 469 ? 130.698 91.085  124.851 1.00 49.25  ? 469 LEU B CD2 1 
ATOM 7856 N N   . MET B 1 470 ? 129.020 94.309  124.057 1.00 47.93  ? 470 MET B N   1 
ATOM 7857 C CA  . MET B 1 470 ? 129.788 95.416  123.505 1.00 42.00  ? 470 MET B CA  1 
ATOM 7858 C C   . MET B 1 470 ? 128.928 96.458  122.801 1.00 48.03  ? 470 MET B C   1 
ATOM 7859 O O   . MET B 1 470 ? 129.454 97.502  122.401 1.00 42.95  ? 470 MET B O   1 
ATOM 7860 C CB  . MET B 1 470 ? 130.845 94.886  122.530 1.00 39.05  ? 470 MET B CB  1 
ATOM 7861 C CG  . MET B 1 470 ? 130.301 94.556  121.155 1.00 41.32  ? 470 MET B CG  1 
ATOM 7862 S SD  . MET B 1 470 ? 131.568 94.555  119.878 1.00 36.72  ? 470 MET B SD  1 
ATOM 7863 C CE  . MET B 1 470 ? 132.502 93.104  120.344 1.00 32.77  ? 470 MET B CE  1 
ATOM 7864 N N   . ASP B 1 471 ? 127.632 96.208  122.638 1.00 66.98  ? 471 ASP B N   1 
ATOM 7865 C CA  . ASP B 1 471 ? 126.787 97.131  121.895 1.00 67.58  ? 471 ASP B CA  1 
ATOM 7866 C C   . ASP B 1 471 ? 126.524 98.396  122.710 1.00 66.27  ? 471 ASP B C   1 
ATOM 7867 O O   . ASP B 1 471 ? 126.337 98.326  123.928 1.00 69.39  ? 471 ASP B O   1 
ATOM 7868 C CB  . ASP B 1 471 ? 125.467 96.466  121.513 1.00 63.31  ? 471 ASP B CB  1 
ATOM 7869 C CG  . ASP B 1 471 ? 125.432 96.045  120.058 1.00 65.00  ? 471 ASP B CG  1 
ATOM 7870 O OD1 . ASP B 1 471 ? 126.042 96.744  119.222 1.00 70.82  ? 471 ASP B OD1 1 
ATOM 7871 O OD2 . ASP B 1 471 ? 124.787 95.023  119.747 1.00 67.41  ? 471 ASP B OD2 1 
ATOM 7872 N N   . PRO B 1 472 ? 126.512 99.566  122.065 1.00 70.35  ? 472 PRO B N   1 
ATOM 7873 C CA  . PRO B 1 472 ? 126.366 100.832 122.798 1.00 74.97  ? 472 PRO B CA  1 
ATOM 7874 C C   . PRO B 1 472 ? 124.990 101.069 123.404 1.00 70.79  ? 472 PRO B C   1 
ATOM 7875 O O   . PRO B 1 472 ? 124.877 101.376 124.594 1.00 67.25  ? 472 PRO B O   1 
ATOM 7876 C CB  . PRO B 1 472 ? 126.676 101.884 121.726 1.00 72.02  ? 472 PRO B CB  1 
ATOM 7877 C CG  . PRO B 1 472 ? 126.357 101.207 120.434 1.00 67.93  ? 472 PRO B CG  1 
ATOM 7878 C CD  . PRO B 1 472 ? 126.684 99.772  120.617 1.00 64.46  ? 472 PRO B CD  1 
ATOM 7879 N N   . LEU B 1 473 ? 123.938 100.939 122.592 1.00 67.53  ? 473 LEU B N   1 
ATOM 7880 C CA  . LEU B 1 473 ? 122.607 101.350 123.023 1.00 67.96  ? 473 LEU B CA  1 
ATOM 7881 C C   . LEU B 1 473 ? 121.969 100.345 123.972 1.00 66.91  ? 473 LEU B C   1 
ATOM 7882 O O   . LEU B 1 473 ? 121.135 100.731 124.798 1.00 67.17  ? 473 LEU B O   1 
ATOM 7883 C CB  . LEU B 1 473 ? 121.710 101.594 121.806 1.00 67.89  ? 473 LEU B CB  1 
ATOM 7884 C CG  . LEU B 1 473 ? 120.872 100.464 121.207 1.00 70.14  ? 473 LEU B CG  1 
ATOM 7885 C CD1 . LEU B 1 473 ? 119.851 101.044 120.247 1.00 68.79  ? 473 LEU B CD1 1 
ATOM 7886 C CD2 . LEU B 1 473 ? 121.744 99.440  120.503 1.00 71.41  ? 473 LEU B CD2 1 
ATOM 7887 N N   . LEU B 1 474 ? 122.342 99.068  123.881 1.00 64.08  ? 474 LEU B N   1 
ATOM 7888 C CA  . LEU B 1 474 ? 121.829 98.088  124.829 1.00 66.13  ? 474 LEU B CA  1 
ATOM 7889 C C   . LEU B 1 474 ? 122.826 96.956  125.047 1.00 67.82  ? 474 LEU B C   1 
ATOM 7890 O O   . LEU B 1 474 ? 123.330 96.362  124.085 1.00 64.81  ? 474 LEU B O   1 
ATOM 7891 C CB  . LEU B 1 474 ? 120.452 97.576  124.375 1.00 65.49  ? 474 LEU B CB  1 
ATOM 7892 C CG  . LEU B 1 474 ? 120.069 96.771  123.123 1.00 68.50  ? 474 LEU B CG  1 
ATOM 7893 C CD1 . LEU B 1 474 ? 120.478 95.302  123.133 1.00 65.65  ? 474 LEU B CD1 1 
ATOM 7894 C CD2 . LEU B 1 474 ? 118.563 96.896  122.936 1.00 67.64  ? 474 LEU B CD2 1 
ATOM 7895 N N   . PRO B 1 475 ? 123.174 96.671  126.300 1.00 63.49  ? 475 PRO B N   1 
ATOM 7896 C CA  . PRO B 1 475 ? 124.017 95.506  126.594 1.00 61.00  ? 475 PRO B CA  1 
ATOM 7897 C C   . PRO B 1 475 ? 123.233 94.203  126.645 1.00 61.52  ? 475 PRO B C   1 
ATOM 7898 O O   . PRO B 1 475 ? 122.053 94.166  126.286 1.00 65.07  ? 475 PRO B O   1 
ATOM 7899 C CB  . PRO B 1 475 ? 124.620 95.852  127.957 1.00 60.78  ? 475 PRO B CB  1 
ATOM 7900 C CG  . PRO B 1 475 ? 123.626 96.760  128.582 1.00 58.29  ? 475 PRO B CG  1 
ATOM 7901 C CD  . PRO B 1 475 ? 123.044 97.566  127.462 1.00 60.69  ? 475 PRO B CD  1 
ATOM 7902 N N   . LEU B 1 476 ? 123.899 93.120  127.065 1.00 53.78  ? 476 LEU B N   1 
ATOM 7903 C CA  . LEU B 1 476 ? 123.258 91.807  127.103 1.00 54.68  ? 476 LEU B CA  1 
ATOM 7904 C C   . LEU B 1 476 ? 122.156 91.751  128.154 1.00 57.42  ? 476 LEU B C   1 
ATOM 7905 O O   . LEU B 1 476 ? 121.157 91.044  127.979 1.00 55.97  ? 476 LEU B O   1 
ATOM 7906 C CB  . LEU B 1 476 ? 124.303 90.719  127.365 1.00 49.91  ? 476 LEU B CB  1 
ATOM 7907 C CG  . LEU B 1 476 ? 123.821 89.263  127.436 1.00 56.22  ? 476 LEU B CG  1 
ATOM 7908 C CD1 . LEU B 1 476 ? 124.645 88.355  126.533 1.00 53.49  ? 476 LEU B CD1 1 
ATOM 7909 C CD2 . LEU B 1 476 ? 123.837 88.746  128.870 1.00 55.14  ? 476 LEU B CD2 1 
ATOM 7910 N N   . SER B 1 477 ? 122.303 92.506  129.241 1.00 61.56  ? 477 SER B N   1 
ATOM 7911 C CA  . SER B 1 477 ? 121.341 92.477  130.336 1.00 53.97  ? 477 SER B CA  1 
ATOM 7912 C C   . SER B 1 477 ? 120.099 93.323  130.069 1.00 52.48  ? 477 SER B C   1 
ATOM 7913 O O   . SER B 1 477 ? 119.369 93.642  131.015 1.00 52.81  ? 477 SER B O   1 
ATOM 7914 C CB  . SER B 1 477 ? 122.009 92.925  131.636 1.00 57.90  ? 477 SER B CB  1 
ATOM 7915 O OG  . SER B 1 477 ? 122.889 91.930  132.127 1.00 64.91  ? 477 SER B OG  1 
ATOM 7916 N N   . VAL B 1 478 ? 119.848 93.697  128.820 1.00 57.52  ? 478 VAL B N   1 
ATOM 7917 C CA  . VAL B 1 478 ? 118.605 94.344  128.426 1.00 59.84  ? 478 VAL B CA  1 
ATOM 7918 C C   . VAL B 1 478 ? 117.612 93.336  127.864 1.00 58.49  ? 478 VAL B C   1 
ATOM 7919 O O   . VAL B 1 478 ? 116.480 93.238  128.338 1.00 57.67  ? 478 VAL B O   1 
ATOM 7920 C CB  . VAL B 1 478 ? 118.892 95.476  127.414 1.00 53.46  ? 478 VAL B CB  1 
ATOM 7921 C CG1 . VAL B 1 478 ? 117.614 95.918  126.721 1.00 58.36  ? 478 VAL B CG1 1 
ATOM 7922 C CG2 . VAL B 1 478 ? 119.541 96.642  128.118 1.00 56.28  ? 478 VAL B CG2 1 
ATOM 7923 N N   . LEU B 1 479 ? 118.027 92.561  126.862 1.00 51.85  ? 479 LEU B N   1 
ATOM 7924 C CA  . LEU B 1 479 ? 117.158 91.561  126.260 1.00 50.02  ? 479 LEU B CA  1 
ATOM 7925 C C   . LEU B 1 479 ? 117.085 90.267  127.056 1.00 52.85  ? 479 LEU B C   1 
ATOM 7926 O O   . LEU B 1 479 ? 116.097 89.538  126.926 1.00 59.29  ? 479 LEU B O   1 
ATOM 7927 C CB  . LEU B 1 479 ? 117.610 91.280  124.817 1.00 51.48  ? 479 LEU B CB  1 
ATOM 7928 C CG  . LEU B 1 479 ? 118.715 90.294  124.414 1.00 55.93  ? 479 LEU B CG  1 
ATOM 7929 C CD1 . LEU B 1 479 ? 118.290 88.824  124.314 1.00 45.88  ? 479 LEU B CD1 1 
ATOM 7930 C CD2 . LEU B 1 479 ? 119.311 90.759  123.103 1.00 59.33  ? 479 LEU B CD2 1 
ATOM 7931 N N   . SER B 1 480 ? 118.103 89.951  127.853 1.00 55.61  ? 480 SER B N   1 
ATOM 7932 C CA  . SER B 1 480 ? 118.022 88.769  128.701 1.00 50.18  ? 480 SER B CA  1 
ATOM 7933 C C   . SER B 1 480 ? 117.072 88.974  129.871 1.00 53.89  ? 480 SER B C   1 
ATOM 7934 O O   . SER B 1 480 ? 116.535 87.994  130.395 1.00 51.24  ? 480 SER B O   1 
ATOM 7935 C CB  . SER B 1 480 ? 119.411 88.387  129.214 1.00 56.16  ? 480 SER B CB  1 
ATOM 7936 O OG  . SER B 1 480 ? 120.052 87.484  128.329 1.00 54.26  ? 480 SER B OG  1 
ATOM 7937 N N   . LYS B 1 481 ? 116.860 90.220  130.292 1.00 61.23  ? 481 LYS B N   1 
ATOM 7938 C CA  . LYS B 1 481 ? 115.913 90.538  131.351 1.00 58.80  ? 481 LYS B CA  1 
ATOM 7939 C C   . LYS B 1 481 ? 114.582 91.051  130.824 1.00 57.14  ? 481 LYS B C   1 
ATOM 7940 O O   . LYS B 1 481 ? 113.694 91.355  131.626 1.00 63.12  ? 481 LYS B O   1 
ATOM 7941 C CB  . LYS B 1 481 ? 116.516 91.563  132.315 1.00 62.89  ? 481 LYS B CB  1 
ATOM 7942 C CG  . LYS B 1 481 ? 117.229 90.938  133.503 1.00 67.48  ? 481 LYS B CG  1 
ATOM 7943 C CD  . LYS B 1 481 ? 117.390 91.935  134.637 1.00 62.75  ? 481 LYS B CD  1 
ATOM 7944 C CE  . LYS B 1 481 ? 118.420 92.992  134.297 1.00 59.62  ? 481 LYS B CE  1 
ATOM 7945 N NZ  . LYS B 1 481 ? 119.756 92.394  134.053 1.00 56.53  ? 481 LYS B NZ  1 
ATOM 7946 N N   . CYS B 1 482 ? 114.418 91.164  129.506 1.00 61.30  ? 482 CYS B N   1 
ATOM 7947 C CA  . CYS B 1 482 ? 113.117 91.481  128.934 1.00 64.51  ? 482 CYS B CA  1 
ATOM 7948 C C   . CYS B 1 482 ? 112.276 90.240  128.672 1.00 54.36  ? 482 CYS B C   1 
ATOM 7949 O O   . CYS B 1 482 ? 111.103 90.371  128.308 1.00 48.42  ? 482 CYS B O   1 
ATOM 7950 C CB  . CYS B 1 482 ? 113.272 92.271  127.628 1.00 58.78  ? 482 CYS B CB  1 
ATOM 7951 S SG  . CYS B 1 482 ? 113.344 91.261  126.131 1.00 55.21  ? 482 CYS B SG  1 
ATOM 7952 N N   . VAL B 1 483 ? 112.841 89.047  128.848 1.00 48.90  ? 483 VAL B N   1 
ATOM 7953 C CA  . VAL B 1 483 ? 112.061 87.827  128.698 1.00 41.90  ? 483 VAL B CA  1 
ATOM 7954 C C   . VAL B 1 483 ? 111.527 87.337  130.042 1.00 49.99  ? 483 VAL B C   1 
ATOM 7955 O O   . VAL B 1 483 ? 110.595 86.531  130.078 1.00 58.02  ? 483 VAL B O   1 
ATOM 7956 C CB  . VAL B 1 483 ? 112.888 86.740  127.990 1.00 51.17  ? 483 VAL B CB  1 
ATOM 7957 C CG1 . VAL B 1 483 ? 113.776 85.992  128.978 1.00 58.63  ? 483 VAL B CG1 1 
ATOM 7958 C CG2 . VAL B 1 483 ? 111.974 85.781  127.248 1.00 55.38  ? 483 VAL B CG2 1 
ATOM 7959 N N   . SER B 1 484 ? 112.092 87.806  131.157 1.00 54.57  ? 484 SER B N   1 
ATOM 7960 C CA  . SER B 1 484 ? 111.441 87.579  132.441 1.00 56.55  ? 484 SER B CA  1 
ATOM 7961 C C   . SER B 1 484 ? 110.189 88.432  132.568 1.00 54.90  ? 484 SER B C   1 
ATOM 7962 O O   . SER B 1 484 ? 109.243 88.052  133.267 1.00 50.07  ? 484 SER B O   1 
ATOM 7963 C CB  . SER B 1 484 ? 112.408 87.872  133.589 1.00 55.65  ? 484 SER B CB  1 
ATOM 7964 O OG  . SER B 1 484 ? 112.360 89.239  133.959 1.00 59.31  ? 484 SER B OG  1 
ATOM 7965 N N   . ALA B 1 485 ? 110.175 89.587  131.902 1.00 57.97  ? 485 ALA B N   1 
ATOM 7966 C CA  . ALA B 1 485 ? 108.982 90.421  131.869 1.00 61.58  ? 485 ALA B CA  1 
ATOM 7967 C C   . ALA B 1 485 ? 107.879 89.771  131.044 1.00 60.17  ? 485 ALA B C   1 
ATOM 7968 O O   . ALA B 1 485 ? 106.729 89.686  131.488 1.00 61.27  ? 485 ALA B O   1 
ATOM 7969 C CB  . ALA B 1 485 ? 109.330 91.800  131.312 1.00 54.96  ? 485 ALA B CB  1 
ATOM 7970 N N   . TYR B 1 486 ? 108.213 89.306  129.838 1.00 51.33  ? 486 TYR B N   1 
ATOM 7971 C CA  . TYR B 1 486 ? 107.229 88.664  128.976 1.00 47.58  ? 486 TYR B CA  1 
ATOM 7972 C C   . TYR B 1 486 ? 106.731 87.341  129.546 1.00 55.91  ? 486 TYR B C   1 
ATOM 7973 O O   . TYR B 1 486 ? 105.526 87.090  129.510 1.00 61.96  ? 486 TYR B O   1 
ATOM 7974 C CB  . TYR B 1 486 ? 107.816 88.461  127.573 1.00 49.97  ? 486 TYR B CB  1 
ATOM 7975 C CG  . TYR B 1 486 ? 106.825 88.079  126.487 1.00 50.44  ? 486 TYR B CG  1 
ATOM 7976 C CD1 . TYR B 1 486 ? 107.264 87.495  125.307 1.00 57.81  ? 486 TYR B CD1 1 
ATOM 7977 C CD2 . TYR B 1 486 ? 105.464 88.316  126.629 1.00 54.56  ? 486 TYR B CD2 1 
ATOM 7978 C CE1 . TYR B 1 486 ? 106.374 87.130  124.310 1.00 62.23  ? 486 TYR B CE1 1 
ATOM 7979 C CE2 . TYR B 1 486 ? 104.565 87.957  125.636 1.00 54.42  ? 486 TYR B CE2 1 
ATOM 7980 C CZ  . TYR B 1 486 ? 105.025 87.363  124.479 1.00 51.81  ? 486 TYR B CZ  1 
ATOM 7981 O OH  . TYR B 1 486 ? 104.139 87.018  123.484 1.00 43.04  ? 486 TYR B OH  1 
ATOM 7982 N N   . ALA B 1 487 ? 107.607 86.512  130.110 1.00 59.39  ? 487 ALA B N   1 
ATOM 7983 C CA  . ALA B 1 487 ? 107.181 85.230  130.654 1.00 59.00  ? 487 ALA B CA  1 
ATOM 7984 C C   . ALA B 1 487 ? 106.552 85.335  132.035 1.00 63.43  ? 487 ALA B C   1 
ATOM 7985 O O   . ALA B 1 487 ? 105.918 84.372  132.478 1.00 62.56  ? 487 ALA B O   1 
ATOM 7986 C CB  . ALA B 1 487 ? 108.358 84.251  130.713 1.00 60.23  ? 487 ALA B CB  1 
ATOM 7987 N N   . GLY B 1 488 ? 106.691 86.470  132.715 1.00 69.19  ? 488 GLY B N   1 
ATOM 7988 C CA  . GLY B 1 488 ? 106.149 86.616  134.052 1.00 65.57  ? 488 GLY B CA  1 
ATOM 7989 C C   . GLY B 1 488 ? 106.816 85.713  135.068 1.00 67.64  ? 488 GLY B C   1 
ATOM 7990 O O   . GLY B 1 488 ? 106.139 85.060  135.868 1.00 68.43  ? 488 GLY B O   1 
ATOM 7991 N N   . ALA B 1 489 ? 108.146 85.657  135.028 1.00 82.99  ? 489 ALA B N   1 
ATOM 7992 C CA  . ALA B 1 489 ? 108.902 84.814  135.942 1.00 85.48  ? 489 ALA B CA  1 
ATOM 7993 C C   . ALA B 1 489 ? 108.796 85.325  137.376 1.00 82.91  ? 489 ALA B C   1 
ATOM 7994 O O   . ALA B 1 489 ? 108.620 86.520  137.625 1.00 83.50  ? 489 ALA B O   1 
ATOM 7995 C CB  . ALA B 1 489 ? 110.369 84.753  135.517 1.00 83.71  ? 489 ALA B CB  1 
ATOM 7996 N N   . LYS B 1 490 ? 108.902 84.398  138.323 1.00 96.51  ? 490 LYS B N   1 
ATOM 7997 C CA  . LYS B 1 490 ? 108.817 84.710  139.744 1.00 95.88  ? 490 LYS B CA  1 
ATOM 7998 C C   . LYS B 1 490 ? 110.219 84.886  140.312 1.00 97.95  ? 490 LYS B C   1 
ATOM 7999 O O   . LYS B 1 490 ? 111.094 84.043  140.093 1.00 95.78  ? 490 LYS B O   1 
ATOM 8000 C CB  . LYS B 1 490 ? 108.074 83.607  140.501 1.00 97.60  ? 490 LYS B CB  1 
ATOM 8001 C CG  . LYS B 1 490 ? 106.909 83.002  139.734 1.00 95.61  ? 490 LYS B CG  1 
ATOM 8002 C CD  . LYS B 1 490 ? 106.795 81.509  139.994 1.00 97.02  ? 490 LYS B CD  1 
ATOM 8003 C CE  . LYS B 1 490 ? 105.875 80.842  138.985 1.00 95.81  ? 490 LYS B CE  1 
ATOM 8004 N NZ  . LYS B 1 490 ? 106.389 80.969  137.593 1.00 94.74  ? 490 LYS B NZ  1 
ATOM 8005 N N   . THR B 1 491 ? 110.426 85.980  141.038 1.00 112.17 ? 491 THR B N   1 
ATOM 8006 C CA  . THR B 1 491 ? 111.722 86.263  141.643 1.00 110.88 ? 491 THR B CA  1 
ATOM 8007 C C   . THR B 1 491 ? 111.852 85.578  143.000 1.00 108.03 ? 491 THR B C   1 
ATOM 8008 O O   . THR B 1 491 ? 112.926 85.570  143.601 1.00 103.69 ? 491 THR B O   1 
ATOM 8009 C CB  . THR B 1 491 ? 111.948 87.776  141.817 1.00 108.12 ? 491 THR B CB  1 
ATOM 8010 O OG1 . THR B 1 491 ? 110.904 88.327  142.629 1.00 106.65 ? 491 THR B OG1 1 
ATOM 8011 C CG2 . THR B 1 491 ? 111.955 88.472  140.466 1.00 106.65 ? 491 THR B CG2 1 
ATOM 8012 N N   . ALA B 1 638 ? 139.618 73.174  128.734 1.00 83.76  ? 638 ALA B N   1 
ATOM 8013 C CA  . ALA B 1 638 ? 140.032 74.281  129.588 1.00 85.84  ? 638 ALA B CA  1 
ATOM 8014 C C   . ALA B 1 638 ? 139.318 75.567  129.192 1.00 83.40  ? 638 ALA B C   1 
ATOM 8015 O O   . ALA B 1 638 ? 138.961 75.756  128.029 1.00 83.28  ? 638 ALA B O   1 
ATOM 8016 C CB  . ALA B 1 638 ? 141.540 74.469  129.521 1.00 84.56  ? 638 ALA B CB  1 
ATOM 8017 N N   . ALA B 1 639 ? 139.101 76.445  130.176 1.00 81.13  ? 639 ALA B N   1 
ATOM 8018 C CA  . ALA B 1 639 ? 138.471 77.731  129.896 1.00 81.59  ? 639 ALA B CA  1 
ATOM 8019 C C   . ALA B 1 639 ? 139.383 78.626  129.067 1.00 82.04  ? 639 ALA B C   1 
ATOM 8020 O O   . ALA B 1 639 ? 138.924 79.299  128.137 1.00 83.92  ? 639 ALA B O   1 
ATOM 8021 C CB  . ALA B 1 639 ? 138.085 78.421  131.203 1.00 81.00  ? 639 ALA B CB  1 
ATOM 8022 N N   . PHE B 1 640 ? 140.676 78.642  129.386 1.00 77.93  ? 640 PHE B N   1 
ATOM 8023 C CA  . PHE B 1 640 ? 141.644 79.469  128.682 1.00 76.08  ? 640 PHE B CA  1 
ATOM 8024 C C   . PHE B 1 640 ? 143.024 78.869  128.889 1.00 78.32  ? 640 PHE B C   1 
ATOM 8025 O O   . PHE B 1 640 ? 143.258 78.211  129.909 1.00 80.64  ? 640 PHE B O   1 
ATOM 8026 C CB  . PHE B 1 640 ? 141.604 80.917  129.191 1.00 79.03  ? 640 PHE B CB  1 
ATOM 8027 C CG  . PHE B 1 640 ? 140.739 81.822  128.365 1.00 76.60  ? 640 PHE B CG  1 
ATOM 8028 C CD1 . PHE B 1 640 ? 140.823 81.808  126.983 1.00 73.23  ? 640 PHE B CD1 1 
ATOM 8029 C CD2 . PHE B 1 640 ? 139.833 82.678  128.970 1.00 77.23  ? 640 PHE B CD2 1 
ATOM 8030 C CE1 . PHE B 1 640 ? 140.028 82.636  126.220 1.00 75.57  ? 640 PHE B CE1 1 
ATOM 8031 C CE2 . PHE B 1 640 ? 139.035 83.509  128.211 1.00 78.09  ? 640 PHE B CE2 1 
ATOM 8032 C CZ  . PHE B 1 640 ? 139.132 83.487  126.833 1.00 81.37  ? 640 PHE B CZ  1 
ATOM 8033 N N   . PRO B 1 641 ? 143.947 79.053  127.944 1.00 90.18  ? 641 PRO B N   1 
ATOM 8034 C CA  . PRO B 1 641 ? 145.313 78.559  128.145 1.00 93.21  ? 641 PRO B CA  1 
ATOM 8035 C C   . PRO B 1 641 ? 146.024 79.306  129.262 1.00 88.25  ? 641 PRO B C   1 
ATOM 8036 O O   . PRO B 1 641 ? 145.695 80.451  129.586 1.00 88.12  ? 641 PRO B O   1 
ATOM 8037 C CB  . PRO B 1 641 ? 145.989 78.808  126.790 1.00 89.28  ? 641 PRO B CB  1 
ATOM 8038 C CG  . PRO B 1 641 ? 145.147 79.840  126.119 1.00 87.72  ? 641 PRO B CG  1 
ATOM 8039 C CD  . PRO B 1 641 ? 143.750 79.588  126.585 1.00 87.48  ? 641 PRO B CD  1 
ATOM 8040 N N   . GLU B 1 642 ? 147.001 78.629  129.864 1.00 93.29  ? 642 GLU B N   1 
ATOM 8041 C CA  . GLU B 1 642 ? 147.747 79.202  130.976 1.00 92.76  ? 642 GLU B CA  1 
ATOM 8042 C C   . GLU B 1 642 ? 148.600 80.376  130.512 1.00 93.90  ? 642 GLU B C   1 
ATOM 8043 O O   . GLU B 1 642 ? 149.213 80.337  129.441 1.00 92.84  ? 642 GLU B O   1 
ATOM 8044 C CB  . GLU B 1 642 ? 148.631 78.139  131.628 1.00 93.90  ? 642 GLU B CB  1 
ATOM 8045 C CG  . GLU B 1 642 ? 147.863 76.990  132.261 1.00 94.71  ? 642 GLU B CG  1 
ATOM 8046 C CD  . GLU B 1 642 ? 147.763 75.782  131.351 1.00 94.04  ? 642 GLU B CD  1 
ATOM 8047 O OE1 . GLU B 1 642 ? 147.571 75.966  130.130 1.00 95.88  ? 642 GLU B OE1 1 
ATOM 8048 O OE2 . GLU B 1 642 ? 147.879 74.645  131.856 1.00 92.81  ? 642 GLU B OE2 1 
ATOM 8049 N N   . GLY B 1 643 ? 148.634 81.425  131.329 1.00 90.47  ? 643 GLY B N   1 
ATOM 8050 C CA  . GLY B 1 643 ? 149.368 82.631  131.032 1.00 92.39  ? 643 GLY B CA  1 
ATOM 8051 C C   . GLY B 1 643 ? 148.536 83.737  130.417 1.00 92.23  ? 643 GLY B C   1 
ATOM 8052 O O   . GLY B 1 643 ? 148.945 84.903  130.472 1.00 90.32  ? 643 GLY B O   1 
ATOM 8053 N N   . PHE B 1 644 ? 147.381 83.407  129.844 1.00 81.69  ? 644 PHE B N   1 
ATOM 8054 C CA  . PHE B 1 644 ? 146.485 84.406  129.266 1.00 81.94  ? 644 PHE B CA  1 
ATOM 8055 C C   . PHE B 1 644 ? 145.545 84.867  130.369 1.00 82.89  ? 644 PHE B C   1 
ATOM 8056 O O   . PHE B 1 644 ? 144.582 84.177  130.712 1.00 81.15  ? 644 PHE B O   1 
ATOM 8057 C CB  . PHE B 1 644 ? 145.731 83.832  128.071 1.00 82.82  ? 644 PHE B CB  1 
ATOM 8058 C CG  . PHE B 1 644 ? 144.634 84.723  127.555 1.00 82.67  ? 644 PHE B CG  1 
ATOM 8059 C CD1 . PHE B 1 644 ? 143.305 84.458  127.847 1.00 82.18  ? 644 PHE B CD1 1 
ATOM 8060 C CD2 . PHE B 1 644 ? 144.935 85.832  126.783 1.00 82.76  ? 644 PHE B CD2 1 
ATOM 8061 C CE1 . PHE B 1 644 ? 142.299 85.278  127.373 1.00 81.87  ? 644 PHE B CE1 1 
ATOM 8062 C CE2 . PHE B 1 644 ? 143.934 86.657  126.308 1.00 79.67  ? 644 PHE B CE2 1 
ATOM 8063 C CZ  . PHE B 1 644 ? 142.615 86.379  126.604 1.00 76.70  ? 644 PHE B CZ  1 
ATOM 8064 N N   . HIS B 1 645 ? 145.837 86.028  130.947 1.00 97.52  ? 645 HIS B N   1 
ATOM 8065 C CA  . HIS B 1 645 ? 145.047 86.587  132.042 1.00 98.24  ? 645 HIS B CA  1 
ATOM 8066 C C   . HIS B 1 645 ? 144.767 88.059  131.769 1.00 98.16  ? 645 HIS B C   1 
ATOM 8067 O O   . HIS B 1 645 ? 145.473 88.943  132.274 1.00 95.99  ? 645 HIS B O   1 
ATOM 8068 C CB  . HIS B 1 645 ? 145.757 86.395  133.383 1.00 96.18  ? 645 HIS B CB  1 
ATOM 8069 C CG  . HIS B 1 645 ? 145.516 85.054  134.004 1.00 96.21  ? 645 HIS B CG  1 
ATOM 8070 N ND1 . HIS B 1 645 ? 146.088 83.897  133.520 1.00 96.11  ? 645 HIS B ND1 1 
ATOM 8071 C CD2 . HIS B 1 645 ? 144.758 84.684  135.063 1.00 96.37  ? 645 HIS B CD2 1 
ATOM 8072 C CE1 . HIS B 1 645 ? 145.697 82.873  134.258 1.00 99.22  ? 645 HIS B CE1 1 
ATOM 8073 N NE2 . HIS B 1 645 ? 144.890 83.324  135.201 1.00 101.33 ? 645 HIS B NE2 1 
ATOM 8074 N N   . PRO B 1 646 ? 143.736 88.362  130.971 1.00 98.89  ? 646 PRO B N   1 
ATOM 8075 C CA  . PRO B 1 646 ? 143.315 89.761  130.817 1.00 101.33 ? 646 PRO B CA  1 
ATOM 8076 C C   . PRO B 1 646 ? 142.523 90.241  132.023 1.00 98.32  ? 646 PRO B C   1 
ATOM 8077 O O   . PRO B 1 646 ? 142.409 89.523  133.022 1.00 95.34  ? 646 PRO B O   1 
ATOM 8078 C CB  . PRO B 1 646 ? 142.458 89.731  129.546 1.00 98.18  ? 646 PRO B CB  1 
ATOM 8079 C CG  . PRO B 1 646 ? 141.903 88.354  129.506 1.00 94.40  ? 646 PRO B CG  1 
ATOM 8080 C CD  . PRO B 1 646 ? 142.915 87.444  130.159 1.00 92.36  ? 646 PRO B CD  1 
ATOM 8081 N N   . ARG B 1 647 ? 141.979 91.454  131.953 1.00 93.12  ? 647 ARG B N   1 
ATOM 8082 C CA  . ARG B 1 647 ? 141.167 91.960  133.052 1.00 93.74  ? 647 ARG B CA  1 
ATOM 8083 C C   . ARG B 1 647 ? 139.840 91.212  133.116 1.00 92.90  ? 647 ARG B C   1 
ATOM 8084 O O   . ARG B 1 647 ? 139.165 91.029  132.099 1.00 89.66  ? 647 ARG B O   1 
ATOM 8085 C CB  . ARG B 1 647 ? 140.929 93.460  132.895 1.00 93.42  ? 647 ARG B CB  1 
ATOM 8086 C CG  . ARG B 1 647 ? 140.969 94.219  134.213 1.00 92.85  ? 647 ARG B CG  1 
ATOM 8087 C CD  . ARG B 1 647 ? 139.569 94.421  134.767 1.00 92.73  ? 647 ARG B CD  1 
ATOM 8088 N NE  . ARG B 1 647 ? 139.554 95.314  135.919 1.00 91.26  ? 647 ARG B NE  1 
ATOM 8089 C CZ  . ARG B 1 647 ? 139.718 94.918  137.174 1.00 93.62  ? 647 ARG B CZ  1 
ATOM 8090 N NH1 . ARG B 1 647 ? 139.908 93.645  137.478 1.00 92.43  ? 647 ARG B NH1 1 
ATOM 8091 N NH2 . ARG B 1 647 ? 139.689 95.823  138.149 1.00 95.25  ? 647 ARG B NH2 1 
ATOM 8092 N N   . ARG B 1 648 ? 139.476 90.769  134.315 1.00 97.27  ? 648 ARG B N   1 
ATOM 8093 C CA  . ARG B 1 648 ? 138.254 90.015  134.542 1.00 94.65  ? 648 ARG B CA  1 
ATOM 8094 C C   . ARG B 1 648 ? 137.363 90.768  135.520 1.00 94.65  ? 648 ARG B C   1 
ATOM 8095 O O   . ARG B 1 648 ? 137.847 91.498  136.390 1.00 93.47  ? 648 ARG B O   1 
ATOM 8096 C CB  . ARG B 1 648 ? 138.557 88.611  135.079 1.00 92.72  ? 648 ARG B CB  1 
ATOM 8097 C CG  . ARG B 1 648 ? 139.768 87.949  134.443 1.00 90.55  ? 648 ARG B CG  1 
ATOM 8098 C CD  . ARG B 1 648 ? 139.535 87.674  132.967 1.00 92.26  ? 648 ARG B CD  1 
ATOM 8099 N NE  . ARG B 1 648 ? 138.696 86.501  132.757 1.00 96.71  ? 648 ARG B NE  1 
ATOM 8100 C CZ  . ARG B 1 648 ? 139.147 85.323  132.349 1.00 97.66  ? 648 ARG B CZ  1 
ATOM 8101 N NH1 . ARG B 1 648 ? 140.431 85.122  132.104 1.00 95.41  ? 648 ARG B NH1 1 
ATOM 8102 N NH2 . ARG B 1 648 ? 138.288 84.322  132.182 1.00 96.21  ? 648 ARG B NH2 1 
ATOM 8103 N N   . SER B 1 649 ? 136.053 90.588  135.367 1.00 89.78  ? 649 SER B N   1 
ATOM 8104 C CA  . SER B 1 649 ? 135.076 91.317  136.169 1.00 91.06  ? 649 SER B CA  1 
ATOM 8105 C C   . SER B 1 649 ? 134.912 90.615  137.511 1.00 90.97  ? 649 SER B C   1 
ATOM 8106 O O   . SER B 1 649 ? 134.332 89.528  137.585 1.00 94.23  ? 649 SER B O   1 
ATOM 8107 C CB  . SER B 1 649 ? 133.745 91.414  135.431 1.00 88.34  ? 649 SER B CB  1 
ATOM 8108 O OG  . SER B 1 649 ? 133.193 90.130  135.201 1.00 89.60  ? 649 SER B OG  1 
ATOM 8109 N N   . SER B 1 650 ? 135.426 91.234  138.570 1.00 89.19  ? 650 SER B N   1 
ATOM 8110 C CA  . SER B 1 650 ? 135.318 90.702  139.921 1.00 90.97  ? 650 SER B CA  1 
ATOM 8111 C C   . SER B 1 650 ? 134.277 91.437  140.755 1.00 89.73  ? 650 SER B C   1 
ATOM 8112 O O   . SER B 1 650 ? 134.277 91.305  141.983 1.00 90.98  ? 650 SER B O   1 
ATOM 8113 C CB  . SER B 1 650 ? 136.677 90.755  140.620 1.00 93.79  ? 650 SER B CB  1 
ATOM 8114 O OG  . SER B 1 650 ? 136.903 92.028  141.199 1.00 93.87  ? 650 SER B OG  1 
ATOM 8115 N N   . GLN B 1 651 ? 133.396 92.206  140.122 1.00 88.18  ? 651 GLN B N   1 
ATOM 8116 C CA  . GLN B 1 651 ? 132.390 92.993  140.836 1.00 92.67  ? 651 GLN B CA  1 
ATOM 8117 C C   . GLN B 1 651 ? 131.124 92.184  141.109 1.00 90.42  ? 651 GLN B C   1 
ATOM 8118 O O   . GLN B 1 651 ? 130.014 92.593  140.770 1.00 88.08  ? 651 GLN B O   1 
ATOM 8119 C CB  . GLN B 1 651 ? 132.072 94.260  140.049 1.00 93.43  ? 651 GLN B CB  1 
ATOM 8120 C CG  . GLN B 1 651 ? 131.961 94.057  138.543 1.00 93.58  ? 651 GLN B CG  1 
ATOM 8121 C CD  . GLN B 1 651 ? 133.207 94.497  137.799 1.00 89.11  ? 651 GLN B CD  1 
ATOM 8122 O OE1 . GLN B 1 651 ? 134.243 94.768  138.406 1.00 87.89  ? 651 GLN B OE1 1 
ATOM 8123 N NE2 . GLN B 1 651 ? 133.110 94.576  136.477 1.00 89.23  ? 651 GLN B NE2 1 
ATOM 8124 N N   . GLY B 1 652 ? 131.286 91.021  141.735 1.00 90.96  ? 652 GLY B N   1 
ATOM 8125 C CA  . GLY B 1 652 ? 130.156 90.181  142.080 1.00 93.70  ? 652 GLY B CA  1 
ATOM 8126 C C   . GLY B 1 652 ? 129.634 89.358  140.920 1.00 94.31  ? 652 GLY B C   1 
ATOM 8127 O O   . GLY B 1 652 ? 129.537 89.850  139.792 1.00 91.06  ? 652 GLY B O   1 
ATOM 8128 N N   . ALA B 1 653 ? 129.286 88.103  141.187 1.00 106.59 ? 653 ALA B N   1 
ATOM 8129 C CA  . ALA B 1 653 ? 128.757 87.209  140.165 1.00 106.10 ? 653 ALA B CA  1 
ATOM 8130 C C   . ALA B 1 653 ? 127.262 87.458  140.008 1.00 102.89 ? 653 ALA B C   1 
ATOM 8131 O O   . ALA B 1 653 ? 126.504 87.353  140.979 1.00 101.86 ? 653 ALA B O   1 
ATOM 8132 C CB  . ALA B 1 653 ? 129.027 85.750  140.529 1.00 105.11 ? 653 ALA B CB  1 
ATOM 8133 N N   . THR B 1 654 ? 126.839 87.785  138.786 1.00 104.72 ? 654 THR B N   1 
ATOM 8134 C CA  . THR B 1 654 ? 125.435 88.083  138.505 1.00 107.91 ? 654 THR B CA  1 
ATOM 8135 C C   . THR B 1 654 ? 124.693 86.768  138.288 1.00 106.33 ? 654 THR B C   1 
ATOM 8136 O O   . THR B 1 654 ? 124.462 86.316  137.163 1.00 104.63 ? 654 THR B O   1 
ATOM 8137 C CB  . THR B 1 654 ? 125.305 89.004  137.297 1.00 109.04 ? 654 THR B CB  1 
ATOM 8138 O OG1 . THR B 1 654 ? 125.546 88.258  136.098 1.00 110.37 ? 654 THR B OG1 1 
ATOM 8139 C CG2 . THR B 1 654 ? 126.310 90.142  137.387 1.00 104.61 ? 654 THR B CG2 1 
ATOM 8140 N N   . GLN B 1 655 ? 124.312 86.142  139.399 1.00 102.07 ? 655 GLN B N   1 
ATOM 8141 C CA  . GLN B 1 655 ? 123.538 84.901  139.363 1.00 101.78 ? 655 GLN B CA  1 
ATOM 8142 C C   . GLN B 1 655 ? 122.040 85.210  139.375 1.00 101.55 ? 655 GLN B C   1 
ATOM 8143 O O   . GLN B 1 655 ? 121.302 84.865  140.297 1.00 100.49 ? 655 GLN B O   1 
ATOM 8144 C CB  . GLN B 1 655 ? 123.931 83.998  140.527 1.00 103.00 ? 655 GLN B CB  1 
ATOM 8145 C CG  . GLN B 1 655 ? 124.044 82.527  140.160 1.00 102.27 ? 655 GLN B CG  1 
ATOM 8146 C CD  . GLN B 1 655 ? 122.692 81.856  140.015 1.00 104.37 ? 655 GLN B CD  1 
ATOM 8147 O OE1 . GLN B 1 655 ? 121.812 82.018  140.861 1.00 104.59 ? 655 GLN B OE1 1 
ATOM 8148 N NE2 . GLN B 1 655 ? 122.519 81.098  138.939 1.00 101.90 ? 655 GLN B NE2 1 
ATOM 8149 N N   . MET B 1 656 ? 121.604 85.890  138.317 1.00 94.30  ? 656 MET B N   1 
ATOM 8150 C CA  . MET B 1 656 ? 120.201 86.236  138.177 1.00 93.74  ? 656 MET B CA  1 
ATOM 8151 C C   . MET B 1 656 ? 119.376 84.984  137.877 1.00 92.97  ? 656 MET B C   1 
ATOM 8152 O O   . MET B 1 656 ? 119.899 83.999  137.350 1.00 93.68  ? 656 MET B O   1 
ATOM 8153 C CB  . MET B 1 656 ? 120.018 87.274  137.069 1.00 97.46  ? 656 MET B CB  1 
ATOM 8154 C CG  . MET B 1 656 ? 120.265 86.754  135.660 1.00 93.56  ? 656 MET B CG  1 
ATOM 8155 S SD  . MET B 1 656 ? 120.740 88.056  134.508 1.00 93.74  ? 656 MET B SD  1 
ATOM 8156 C CE  . MET B 1 656 ? 120.395 87.265  132.939 1.00 94.56  ? 656 MET B CE  1 
ATOM 8157 N N   . PRO B 1 657 ? 118.089 84.976  138.244 1.00 89.21  ? 657 PRO B N   1 
ATOM 8158 C CA  . PRO B 1 657 ? 117.225 83.842  137.885 1.00 87.88  ? 657 PRO B CA  1 
ATOM 8159 C C   . PRO B 1 657 ? 116.785 83.924  136.431 1.00 88.96  ? 657 PRO B C   1 
ATOM 8160 O O   . PRO B 1 657 ? 115.939 84.745  136.064 1.00 88.91  ? 657 PRO B O   1 
ATOM 8161 C CB  . PRO B 1 657 ? 116.042 83.987  138.855 1.00 89.42  ? 657 PRO B CB  1 
ATOM 8162 C CG  . PRO B 1 657 ? 116.022 85.420  139.236 1.00 88.23  ? 657 PRO B CG  1 
ATOM 8163 C CD  . PRO B 1 657 ? 117.439 85.897  139.195 1.00 89.05  ? 657 PRO B CD  1 
ATOM 8164 N N   . LEU B 1 658 ? 117.365 83.067  135.595 1.00 89.95  ? 658 LEU B N   1 
ATOM 8165 C CA  . LEU B 1 658 ? 116.976 82.942  134.196 1.00 88.59  ? 658 LEU B CA  1 
ATOM 8166 C C   . LEU B 1 658 ? 116.430 81.547  133.914 1.00 91.01  ? 658 LEU B C   1 
ATOM 8167 O O   . LEU B 1 658 ? 116.727 80.934  132.886 1.00 91.75  ? 658 LEU B O   1 
ATOM 8168 C CB  . LEU B 1 658 ? 118.140 83.277  133.260 1.00 91.29  ? 658 LEU B CB  1 
ATOM 8169 C CG  . LEU B 1 658 ? 119.491 82.555  133.347 1.00 92.31  ? 658 LEU B CG  1 
ATOM 8170 C CD1 . LEU B 1 658 ? 120.070 82.379  131.952 1.00 90.45  ? 658 LEU B CD1 1 
ATOM 8171 C CD2 . LEU B 1 658 ? 120.470 83.314  134.218 1.00 90.59  ? 658 LEU B CD2 1 
ATOM 8172 N N   . TYR B 1 659 ? 115.617 81.032  134.836 1.00 89.52  ? 659 TYR B N   1 
ATOM 8173 C CA  . TYR B 1 659 ? 115.038 79.705  134.678 1.00 86.60  ? 659 TYR B CA  1 
ATOM 8174 C C   . TYR B 1 659 ? 114.048 79.685  133.519 1.00 87.30  ? 659 TYR B C   1 
ATOM 8175 O O   . TYR B 1 659 ? 113.332 80.659  133.269 1.00 88.86  ? 659 TYR B O   1 
ATOM 8176 C CB  . TYR B 1 659 ? 114.364 79.259  135.979 1.00 86.83  ? 659 TYR B CB  1 
ATOM 8177 C CG  . TYR B 1 659 ? 112.916 79.675  136.131 1.00 89.28  ? 659 TYR B CG  1 
ATOM 8178 C CD1 . TYR B 1 659 ? 112.578 80.993  136.412 1.00 87.01  ? 659 TYR B CD1 1 
ATOM 8179 C CD2 . TYR B 1 659 ? 111.889 78.747  136.006 1.00 88.78  ? 659 TYR B CD2 1 
ATOM 8180 C CE1 . TYR B 1 659 ? 111.256 81.378  136.556 1.00 86.32  ? 659 TYR B CE1 1 
ATOM 8181 C CE2 . TYR B 1 659 ? 110.565 79.123  136.149 1.00 89.12  ? 659 TYR B CE2 1 
ATOM 8182 C CZ  . TYR B 1 659 ? 110.255 80.439  136.423 1.00 89.14  ? 659 TYR B CZ  1 
ATOM 8183 O OH  . TYR B 1 659 ? 108.940 80.816  136.565 1.00 89.70  ? 659 TYR B OH  1 
ATOM 8184 N N   . SER B 1 660 ? 114.032 78.571  132.792 1.00 84.37  ? 660 SER B N   1 
ATOM 8185 C CA  . SER B 1 660 ? 113.220 78.418  131.587 1.00 83.40  ? 660 SER B CA  1 
ATOM 8186 C C   . SER B 1 660 ? 112.166 77.346  131.850 1.00 84.96  ? 660 SER B C   1 
ATOM 8187 O O   . SER B 1 660 ? 112.382 76.162  131.582 1.00 83.51  ? 660 SER B O   1 
ATOM 8188 C CB  . SER B 1 660 ? 114.092 78.069  130.381 1.00 81.89  ? 660 SER B CB  1 
ATOM 8189 O OG  . SER B 1 660 ? 115.162 78.988  130.244 1.00 84.82  ? 660 SER B OG  1 
ATOM 8190 N N   . SER B 1 661 ? 111.023 77.775  132.379 1.00 81.51  ? 661 SER B N   1 
ATOM 8191 C CA  . SER B 1 661 ? 109.871 76.904  132.516 1.00 82.14  ? 661 SER B CA  1 
ATOM 8192 C C   . SER B 1 661 ? 109.307 76.580  131.132 1.00 83.88  ? 661 SER B C   1 
ATOM 8193 O O   . SER B 1 661 ? 109.562 77.307  130.169 1.00 83.83  ? 661 SER B O   1 
ATOM 8194 C CB  . SER B 1 661 ? 108.815 77.574  133.396 1.00 79.08  ? 661 SER B CB  1 
ATOM 8195 O OG  . SER B 1 661 ? 108.650 78.935  133.045 1.00 81.70  ? 661 SER B OG  1 
ATOM 8196 N N   . PRO B 1 662 ? 108.531 75.476  130.999 1.00 84.61  ? 662 PRO B N   1 
ATOM 8197 C CA  . PRO B 1 662 ? 107.991 75.101  129.678 1.00 81.83  ? 662 PRO B CA  1 
ATOM 8198 C C   . PRO B 1 662 ? 107.057 76.107  129.008 1.00 81.41  ? 662 PRO B C   1 
ATOM 8199 O O   . PRO B 1 662 ? 106.580 75.850  127.898 1.00 87.53  ? 662 PRO B O   1 
ATOM 8200 C CB  . PRO B 1 662 ? 107.243 73.794  129.971 1.00 82.14  ? 662 PRO B CB  1 
ATOM 8201 C CG  . PRO B 1 662 ? 107.948 73.209  131.128 1.00 85.06  ? 662 PRO B CG  1 
ATOM 8202 C CD  . PRO B 1 662 ? 108.454 74.355  131.957 1.00 85.34  ? 662 PRO B CD  1 
ATOM 8203 N N   . ILE B 1 663 ? 106.782 77.248  129.652 1.00 78.90  ? 663 ILE B N   1 
ATOM 8204 C CA  . ILE B 1 663 ? 106.006 78.314  129.020 1.00 73.97  ? 663 ILE B CA  1 
ATOM 8205 C C   . ILE B 1 663 ? 106.785 79.065  127.953 1.00 73.11  ? 663 ILE B C   1 
ATOM 8206 O O   . ILE B 1 663 ? 106.195 79.889  127.243 1.00 72.92  ? 663 ILE B O   1 
ATOM 8207 C CB  . ILE B 1 663 ? 105.496 79.324  130.068 1.00 71.84  ? 663 ILE B CB  1 
ATOM 8208 C CG1 . ILE B 1 663 ? 106.669 80.074  130.700 1.00 69.61  ? 663 ILE B CG1 1 
ATOM 8209 C CG2 . ILE B 1 663 ? 104.669 78.617  131.131 1.00 73.81  ? 663 ILE B CG2 1 
ATOM 8210 C CD1 . ILE B 1 663 ? 106.249 81.164  131.660 1.00 73.70  ? 663 ILE B CD1 1 
ATOM 8211 N N   . VAL B 1 664 ? 108.090 78.827  127.827 1.00 74.03  ? 664 VAL B N   1 
ATOM 8212 C CA  . VAL B 1 664 ? 108.873 79.400  126.740 1.00 73.71  ? 664 VAL B CA  1 
ATOM 8213 C C   . VAL B 1 664 ? 109.131 78.402  125.620 1.00 73.60  ? 664 VAL B C   1 
ATOM 8214 O O   . VAL B 1 664 ? 109.635 78.805  124.560 1.00 74.30  ? 664 VAL B O   1 
ATOM 8215 C CB  . VAL B 1 664 ? 110.210 79.978  127.247 1.00 74.83  ? 664 VAL B CB  1 
ATOM 8216 C CG1 . VAL B 1 664 ? 109.969 81.010  128.335 1.00 72.09  ? 664 VAL B CG1 1 
ATOM 8217 C CG2 . VAL B 1 664 ? 111.122 78.864  127.732 1.00 73.49  ? 664 VAL B CG2 1 
ATOM 8218 N N   . LYS B 1 665 ? 108.815 77.121  125.816 1.00 71.40  ? 665 LYS B N   1 
ATOM 8219 C CA  . LYS B 1 665 ? 109.007 76.127  124.769 1.00 74.22  ? 665 LYS B CA  1 
ATOM 8220 C C   . LYS B 1 665 ? 107.929 76.206  123.703 1.00 76.38  ? 665 LYS B C   1 
ATOM 8221 O O   . LYS B 1 665 ? 108.105 75.638  122.619 1.00 74.95  ? 665 LYS B O   1 
ATOM 8222 C CB  . LYS B 1 665 ? 108.998 74.706  125.346 1.00 71.48  ? 665 LYS B CB  1 
ATOM 8223 C CG  . LYS B 1 665 ? 109.884 74.432  126.560 1.00 72.21  ? 665 LYS B CG  1 
ATOM 8224 C CD  . LYS B 1 665 ? 111.239 75.119  126.523 1.00 72.40  ? 665 LYS B CD  1 
ATOM 8225 C CE  . LYS B 1 665 ? 111.864 75.102  127.908 1.00 76.64  ? 665 LYS B CE  1 
ATOM 8226 N NZ  . LYS B 1 665 ? 113.150 75.844  127.959 1.00 73.47  ? 665 LYS B NZ  1 
ATOM 8227 N N   . ASN B 1 666 ? 106.824 76.887  123.992 1.00 70.76  ? 666 ASN B N   1 
ATOM 8228 C CA  . ASN B 1 666 ? 105.655 76.808  123.140 1.00 65.75  ? 666 ASN B CA  1 
ATOM 8229 C C   . ASN B 1 666 ? 105.878 77.578  121.841 1.00 63.40  ? 666 ASN B C   1 
ATOM 8230 O O   . ASN B 1 666 ? 106.729 78.468  121.771 1.00 63.97  ? 666 ASN B O   1 
ATOM 8231 C CB  . ASN B 1 666 ? 104.424 77.356  123.857 1.00 64.59  ? 666 ASN B CB  1 
ATOM 8232 C CG  . ASN B 1 666 ? 104.739 78.553  124.708 1.00 68.06  ? 666 ASN B CG  1 
ATOM 8233 O OD1 . ASN B 1 666 ? 105.765 79.202  124.522 1.00 65.78  ? 666 ASN B OD1 1 
ATOM 8234 N ND2 . ASN B 1 666 ? 103.857 78.859  125.650 1.00 66.58  ? 666 ASN B ND2 1 
ATOM 8235 N N   . PRO B 1 667 ? 105.145 77.217  120.795 1.00 52.39  ? 667 PRO B N   1 
ATOM 8236 C CA  . PRO B 1 667 ? 105.197 77.973  119.537 1.00 48.22  ? 667 PRO B CA  1 
ATOM 8237 C C   . PRO B 1 667 ? 104.888 79.456  119.633 1.00 59.90  ? 667 PRO B C   1 
ATOM 8238 O O   . PRO B 1 667 ? 105.468 80.251  118.884 1.00 61.89  ? 667 PRO B O   1 
ATOM 8239 C CB  . PRO B 1 667 ? 104.120 77.289  118.707 1.00 55.25  ? 667 PRO B CB  1 
ATOM 8240 C CG  . PRO B 1 667 ? 103.735 76.022  119.414 1.00 59.22  ? 667 PRO B CG  1 
ATOM 8241 C CD  . PRO B 1 667 ? 104.597 75.865  120.600 1.00 57.46  ? 667 PRO B CD  1 
ATOM 8242 N N   . PHE B 1 668 ? 103.962 79.848  120.503 1.00 53.57  ? 668 PHE B N   1 
ATOM 8243 C CA  . PHE B 1 668 ? 103.451 81.210  120.536 1.00 52.57  ? 668 PHE B CA  1 
ATOM 8244 C C   . PHE B 1 668 ? 104.294 82.134  121.409 1.00 52.50  ? 668 PHE B C   1 
ATOM 8245 O O   . PHE B 1 668 ? 103.801 83.175  121.859 1.00 53.90  ? 668 PHE B O   1 
ATOM 8246 C CB  . PHE B 1 668 ? 101.990 81.195  120.989 1.00 52.69  ? 668 PHE B CB  1 
ATOM 8247 C CG  . PHE B 1 668 ? 101.111 80.308  120.146 1.00 55.38  ? 668 PHE B CG  1 
ATOM 8248 C CD1 . PHE B 1 668 ? 101.095 80.440  118.766 1.00 51.06  ? 668 PHE B CD1 1 
ATOM 8249 C CD2 . PHE B 1 668 ? 100.330 79.324  120.729 1.00 57.51  ? 668 PHE B CD2 1 
ATOM 8250 C CE1 . PHE B 1 668 ? 100.298 79.625  117.985 1.00 53.14  ? 668 PHE B CE1 1 
ATOM 8251 C CE2 . PHE B 1 668 ? 99.532  78.503  119.952 1.00 54.26  ? 668 PHE B CE2 1 
ATOM 8252 C CZ  . PHE B 1 668 ? 99.517  78.655  118.579 1.00 54.22  ? 668 PHE B CZ  1 
ATOM 8253 N N   . MET B 1 669 ? 105.549 81.765  121.661 1.00 47.45  ? 669 MET B N   1 
ATOM 8254 C CA  . MET B 1 669 ? 106.535 82.635  122.286 1.00 45.56  ? 669 MET B CA  1 
ATOM 8255 C C   . MET B 1 669 ? 107.846 82.698  121.516 1.00 50.06  ? 669 MET B C   1 
ATOM 8256 O O   . MET B 1 669 ? 108.501 83.747  121.537 1.00 51.74  ? 669 MET B O   1 
ATOM 8257 C CB  . MET B 1 669 ? 106.820 82.166  123.721 1.00 50.59  ? 669 MET B CB  1 
ATOM 8258 C CG  . MET B 1 669 ? 107.594 83.131  124.600 1.00 52.64  ? 669 MET B CG  1 
ATOM 8259 S SD  . MET B 1 669 ? 107.158 82.916  126.338 1.00 65.80  ? 669 MET B SD  1 
ATOM 8260 C CE  . MET B 1 669 ? 107.625 84.494  127.032 1.00 44.08  ? 669 MET B CE  1 
ATOM 8261 N N   . SER B 1 670 ? 108.233 81.630  120.816 1.00 45.94  ? 670 SER B N   1 
ATOM 8262 C CA  . SER B 1 670 ? 109.472 81.536  120.053 1.00 42.99  ? 670 SER B CA  1 
ATOM 8263 C C   . SER B 1 670 ? 109.309 80.496  118.950 1.00 47.36  ? 670 SER B C   1 
ATOM 8264 O O   . SER B 1 670 ? 109.538 79.303  119.184 1.00 47.18  ? 670 SER B O   1 
ATOM 8265 C CB  . SER B 1 670 ? 110.635 81.183  120.979 1.00 43.87  ? 670 SER B CB  1 
ATOM 8266 O OG  . SER B 1 670 ? 110.275 80.133  121.859 1.00 35.84  ? 670 SER B OG  1 
ATOM 8267 N N   . PRO B 1 671 ? 108.931 80.906  117.735 1.00 44.38  ? 671 PRO B N   1 
ATOM 8268 C CA  . PRO B 1 671 ? 108.422 79.929  116.755 1.00 55.48  ? 671 PRO B CA  1 
ATOM 8269 C C   . PRO B 1 671 ? 109.480 79.068  116.073 1.00 52.96  ? 671 PRO B C   1 
ATOM 8270 O O   . PRO B 1 671 ? 109.116 78.296  115.178 1.00 46.87  ? 671 PRO B O   1 
ATOM 8271 C CB  . PRO B 1 671 ? 107.689 80.808  115.732 1.00 44.85  ? 671 PRO B CB  1 
ATOM 8272 C CG  . PRO B 1 671 ? 108.272 82.152  115.887 1.00 34.55  ? 671 PRO B CG  1 
ATOM 8273 C CD  . PRO B 1 671 ? 108.686 82.295  117.316 1.00 30.83  ? 671 PRO B CD  1 
ATOM 8274 N N   . LEU B 1 672 ? 110.762 79.162  116.438 1.00 47.47  ? 672 LEU B N   1 
ATOM 8275 C CA  . LEU B 1 672 ? 111.755 78.289  115.810 1.00 53.70  ? 672 LEU B CA  1 
ATOM 8276 C C   . LEU B 1 672 ? 111.637 76.856  116.314 1.00 56.98  ? 672 LEU B C   1 
ATOM 8277 O O   . LEU B 1 672 ? 111.659 75.906  115.523 1.00 66.77  ? 672 LEU B O   1 
ATOM 8278 C CB  . LEU B 1 672 ? 113.172 78.806  116.046 1.00 51.73  ? 672 LEU B CB  1 
ATOM 8279 C CG  . LEU B 1 672 ? 113.822 79.887  115.175 1.00 45.57  ? 672 LEU B CG  1 
ATOM 8280 C CD1 . LEU B 1 672 ? 114.027 79.360  113.778 1.00 51.24  ? 672 LEU B CD1 1 
ATOM 8281 C CD2 . LEU B 1 672 ? 113.048 81.184  115.148 1.00 40.23  ? 672 LEU B CD2 1 
ATOM 8282 N N   . LEU B 1 673 ? 111.515 76.676  117.630 1.00 53.93  ? 673 LEU B N   1 
ATOM 8283 C CA  . LEU B 1 673 ? 111.376 75.350  118.218 1.00 59.61  ? 673 LEU B CA  1 
ATOM 8284 C C   . LEU B 1 673 ? 109.929 74.884  118.259 1.00 59.20  ? 673 LEU B C   1 
ATOM 8285 O O   . LEU B 1 673 ? 109.591 73.992  119.046 1.00 55.23  ? 673 LEU B O   1 
ATOM 8286 C CB  . LEU B 1 673 ? 111.982 75.295  119.628 1.00 54.95  ? 673 LEU B CB  1 
ATOM 8287 C CG  . LEU B 1 673 ? 111.551 76.145  120.828 1.00 51.78  ? 673 LEU B CG  1 
ATOM 8288 C CD1 . LEU B 1 673 ? 112.205 75.579  122.070 1.00 55.81  ? 673 LEU B CD1 1 
ATOM 8289 C CD2 . LEU B 1 673 ? 111.958 77.597  120.695 1.00 56.67  ? 673 LEU B CD2 1 
ATOM 8290 N N   . ALA B 1 674 ? 109.072 75.477  117.438 1.00 53.09  ? 674 ALA B N   1 
ATOM 8291 C CA  . ALA B 1 674 ? 107.705 75.033  117.303 1.00 52.22  ? 674 ALA B CA  1 
ATOM 8292 C C   . ALA B 1 674 ? 107.650 73.719  116.528 1.00 52.50  ? 674 ALA B C   1 
ATOM 8293 O O   . ALA B 1 674 ? 108.605 73.362  115.833 1.00 57.50  ? 674 ALA B O   1 
ATOM 8294 C CB  . ALA B 1 674 ? 106.887 76.105  116.596 1.00 55.80  ? 674 ALA B CB  1 
ATOM 8295 N N   . PRO B 1 675 ? 106.564 72.956  116.677 1.00 63.40  ? 675 PRO B N   1 
ATOM 8296 C CA  . PRO B 1 675 ? 106.372 71.776  115.825 1.00 65.68  ? 675 PRO B CA  1 
ATOM 8297 C C   . PRO B 1 675 ? 106.350 72.153  114.351 1.00 65.14  ? 675 PRO B C   1 
ATOM 8298 O O   . PRO B 1 675 ? 105.807 73.188  113.965 1.00 65.71  ? 675 PRO B O   1 
ATOM 8299 C CB  . PRO B 1 675 ? 105.017 71.225  116.280 1.00 67.47  ? 675 PRO B CB  1 
ATOM 8300 C CG  . PRO B 1 675 ? 104.823 71.725  117.673 1.00 67.45  ? 675 PRO B CG  1 
ATOM 8301 C CD  . PRO B 1 675 ? 105.794 72.836  117.949 1.00 68.32  ? 675 PRO B CD  1 
ATOM 8302 N N   . ASP B 1 676 ? 106.953 71.291  113.531 1.00 69.55  ? 676 ASP B N   1 
ATOM 8303 C CA  . ASP B 1 676 ? 107.185 71.579  112.121 1.00 66.87  ? 676 ASP B CA  1 
ATOM 8304 C C   . ASP B 1 676 ? 105.889 71.687  111.324 1.00 67.76  ? 676 ASP B C   1 
ATOM 8305 O O   . ASP B 1 676 ? 105.786 72.557  110.453 1.00 71.77  ? 676 ASP B O   1 
ATOM 8306 C CB  . ASP B 1 676 ? 108.082 70.485  111.527 1.00 71.97  ? 676 ASP B CB  1 
ATOM 8307 C CG  . ASP B 1 676 ? 108.617 70.829  110.143 1.00 75.15  ? 676 ASP B CG  1 
ATOM 8308 O OD1 . ASP B 1 676 ? 109.321 69.976  109.564 1.00 83.71  ? 676 ASP B OD1 1 
ATOM 8309 O OD2 . ASP B 1 676 ? 108.391 71.952  109.651 1.00 72.16  ? 676 ASP B OD2 1 
ATOM 8310 N N   . SER B 1 677 ? 104.886 70.862  111.638 1.00 79.96  ? 677 SER B N   1 
ATOM 8311 C CA  . SER B 1 677 ? 103.675 70.747  110.832 1.00 76.61  ? 677 SER B CA  1 
ATOM 8312 C C   . SER B 1 677 ? 102.805 71.995  110.851 1.00 72.22  ? 677 SER B C   1 
ATOM 8313 O O   . SER B 1 677 ? 101.868 72.081  110.052 1.00 72.63  ? 677 SER B O   1 
ATOM 8314 C CB  . SER B 1 677 ? 102.843 69.554  111.306 1.00 73.91  ? 677 SER B CB  1 
ATOM 8315 O OG  . SER B 1 677 ? 102.369 69.757  112.627 1.00 73.83  ? 677 SER B OG  1 
ATOM 8316 N N   . MET B 1 678 ? 103.066 72.951  111.736 1.00 65.72  ? 678 MET B N   1 
ATOM 8317 C CA  . MET B 1 678 ? 102.228 74.138  111.795 1.00 71.21  ? 678 MET B CA  1 
ATOM 8318 C C   . MET B 1 678 ? 102.864 75.347  111.126 1.00 69.38  ? 678 MET B C   1 
ATOM 8319 O O   . MET B 1 678 ? 102.144 76.268  110.727 1.00 71.18  ? 678 MET B O   1 
ATOM 8320 C CB  . MET B 1 678 ? 101.859 74.399  113.266 1.00 69.16  ? 678 MET B CB  1 
ATOM 8321 C CG  . MET B 1 678 ? 101.586 75.793  113.793 1.00 66.50  ? 678 MET B CG  1 
ATOM 8322 S SD  . MET B 1 678 ? 103.081 76.747  113.974 1.00 72.54  ? 678 MET B SD  1 
ATOM 8323 C CE  . MET B 1 678 ? 103.408 76.171  115.576 1.00 69.90  ? 678 MET B CE  1 
ATOM 8324 N N   . LEU B 1 679 ? 104.187 75.354  110.946 1.00 59.61  ? 679 LEU B N   1 
ATOM 8325 C CA  . LEU B 1 679 ? 104.822 76.462  110.244 1.00 58.98  ? 679 LEU B CA  1 
ATOM 8326 C C   . LEU B 1 679 ? 104.725 76.326  108.735 1.00 64.84  ? 679 LEU B C   1 
ATOM 8327 O O   . LEU B 1 679 ? 105.245 77.190  108.022 1.00 61.74  ? 679 LEU B O   1 
ATOM 8328 C CB  . LEU B 1 679 ? 106.297 76.591  110.638 1.00 61.87  ? 679 LEU B CB  1 
ATOM 8329 C CG  . LEU B 1 679 ? 106.679 77.144  112.012 1.00 62.20  ? 679 LEU B CG  1 
ATOM 8330 C CD1 . LEU B 1 679 ? 107.114 76.021  112.924 1.00 61.67  ? 679 LEU B CD1 1 
ATOM 8331 C CD2 . LEU B 1 679 ? 107.777 78.187  111.893 1.00 62.86  ? 679 LEU B CD2 1 
ATOM 8332 N N   . LYS B 1 680 ? 104.090 75.263  108.237 1.00 75.82  ? 680 LYS B N   1 
ATOM 8333 C CA  . LYS B 1 680 ? 103.951 75.081  106.796 1.00 71.97  ? 680 LYS B CA  1 
ATOM 8334 C C   . LYS B 1 680 ? 103.012 76.117  106.188 1.00 71.95  ? 680 LYS B C   1 
ATOM 8335 O O   . LYS B 1 680 ? 103.251 76.599  105.075 1.00 71.98  ? 680 LYS B O   1 
ATOM 8336 C CB  . LYS B 1 680 ? 103.457 73.667  106.496 1.00 73.43  ? 680 LYS B CB  1 
ATOM 8337 C CG  . LYS B 1 680 ? 103.911 72.626  107.504 1.00 71.94  ? 680 LYS B CG  1 
ATOM 8338 C CD  . LYS B 1 680 ? 105.344 72.197  107.243 1.00 72.50  ? 680 LYS B CD  1 
ATOM 8339 C CE  . LYS B 1 680 ? 105.493 71.561  105.874 1.00 73.63  ? 680 LYS B CE  1 
ATOM 8340 N NZ  . LYS B 1 680 ? 106.865 71.022  105.668 1.00 77.41  ? 680 LYS B NZ  1 
ATOM 8341 N N   . SER B 1 681 ? 101.947 76.479  106.901 1.00 64.93  ? 681 SER B N   1 
ATOM 8342 C CA  . SER B 1 681 ? 100.949 77.413  106.398 1.00 73.53  ? 681 SER B CA  1 
ATOM 8343 C C   . SER B 1 681 ? 101.281 78.867  106.720 1.00 72.92  ? 681 SER B C   1 
ATOM 8344 O O   . SER B 1 681 ? 100.375 79.707  106.755 1.00 74.77  ? 681 SER B O   1 
ATOM 8345 C CB  . SER B 1 681 ? 99.568  77.056  106.953 1.00 75.80  ? 681 SER B CB  1 
ATOM 8346 O OG  . SER B 1 681 ? 99.276  75.684  106.749 1.00 76.45  ? 681 SER B OG  1 
ATOM 8347 N N   . LEU B 1 682 ? 102.553 79.176  106.956 1.00 56.79  ? 682 LEU B N   1 
ATOM 8348 C CA  . LEU B 1 682 ? 102.968 80.538  107.246 1.00 53.93  ? 682 LEU B CA  1 
ATOM 8349 C C   . LEU B 1 682 ? 102.815 81.425  106.011 1.00 58.09  ? 682 LEU B C   1 
ATOM 8350 O O   . LEU B 1 682 ? 102.974 80.961  104.879 1.00 57.96  ? 682 LEU B O   1 
ATOM 8351 C CB  . LEU B 1 682 ? 104.421 80.552  107.717 1.00 54.85  ? 682 LEU B CB  1 
ATOM 8352 C CG  . LEU B 1 682 ? 104.933 81.705  108.581 1.00 55.56  ? 682 LEU B CG  1 
ATOM 8353 C CD1 . LEU B 1 682 ? 104.546 81.515  110.018 1.00 57.20  ? 682 LEU B CD1 1 
ATOM 8354 C CD2 . LEU B 1 682 ? 106.438 81.804  108.463 1.00 65.25  ? 682 LEU B CD2 1 
ATOM 8355 N N   . PRO B 1 683 ? 102.486 82.699  106.201 1.00 53.41  ? 683 PRO B N   1 
ATOM 8356 C CA  . PRO B 1 683 ? 102.530 83.655  105.092 1.00 54.24  ? 683 PRO B CA  1 
ATOM 8357 C C   . PRO B 1 683 ? 103.960 83.903  104.650 1.00 58.10  ? 683 PRO B C   1 
ATOM 8358 O O   . PRO B 1 683 ? 104.900 83.634  105.412 1.00 62.72  ? 683 PRO B O   1 
ATOM 8359 C CB  . PRO B 1 683 ? 101.912 84.923  105.697 1.00 52.69  ? 683 PRO B CB  1 
ATOM 8360 C CG  . PRO B 1 683 ? 102.027 84.745  107.172 1.00 44.66  ? 683 PRO B CG  1 
ATOM 8361 C CD  . PRO B 1 683 ? 101.876 83.286  107.405 1.00 46.92  ? 683 PRO B CD  1 
ATOM 8362 N N   . PRO B 1 684 ? 104.170 84.372  103.418 1.00 53.46  ? 684 PRO B N   1 
ATOM 8363 C CA  . PRO B 1 684 ? 105.521 84.767  102.999 1.00 46.62  ? 684 PRO B CA  1 
ATOM 8364 C C   . PRO B 1 684 ? 106.066 85.896  103.862 1.00 42.71  ? 684 PRO B C   1 
ATOM 8365 O O   . PRO B 1 684 ? 105.343 86.817  104.245 1.00 35.32  ? 684 PRO B O   1 
ATOM 8366 C CB  . PRO B 1 684 ? 105.325 85.211  101.547 1.00 44.80  ? 684 PRO B CB  1 
ATOM 8367 C CG  . PRO B 1 684 ? 104.131 84.461  101.093 1.00 47.28  ? 684 PRO B CG  1 
ATOM 8368 C CD  . PRO B 1 684 ? 103.228 84.365  102.287 1.00 51.40  ? 684 PRO B CD  1 
ATOM 8369 N N   . VAL B 1 685 ? 107.359 85.811  104.168 1.00 47.14  ? 685 VAL B N   1 
ATOM 8370 C CA  . VAL B 1 685 ? 108.009 86.689  105.132 1.00 45.64  ? 685 VAL B CA  1 
ATOM 8371 C C   . VAL B 1 685 ? 109.147 87.434  104.452 1.00 46.20  ? 685 VAL B C   1 
ATOM 8372 O O   . VAL B 1 685 ? 109.929 86.841  103.701 1.00 44.46  ? 685 VAL B O   1 
ATOM 8373 C CB  . VAL B 1 685 ? 108.543 85.905  106.347 1.00 46.78  ? 685 VAL B CB  1 
ATOM 8374 C CG1 . VAL B 1 685 ? 109.041 86.858  107.399 1.00 40.09  ? 685 VAL B CG1 1 
ATOM 8375 C CG2 . VAL B 1 685 ? 107.471 85.012  106.917 1.00 37.35  ? 685 VAL B CG2 1 
ATOM 8376 N N   . HIS B 1 686 ? 109.235 88.733  104.717 1.00 24.13  ? 686 HIS B N   1 
ATOM 8377 C CA  . HIS B 1 686 ? 110.387 89.542  104.355 1.00 36.23  ? 686 HIS B CA  1 
ATOM 8378 C C   . HIS B 1 686 ? 110.957 90.160  105.623 1.00 40.60  ? 686 HIS B C   1 
ATOM 8379 O O   . HIS B 1 686 ? 110.230 90.810  106.380 1.00 36.49  ? 686 HIS B O   1 
ATOM 8380 C CB  . HIS B 1 686 ? 109.993 90.609  103.338 1.00 38.50  ? 686 HIS B CB  1 
ATOM 8381 C CG  . HIS B 1 686 ? 109.140 90.080  102.229 1.00 33.44  ? 686 HIS B CG  1 
ATOM 8382 N ND1 . HIS B 1 686 ? 109.669 89.554  101.071 1.00 36.99  ? 686 HIS B ND1 1 
ATOM 8383 C CD2 . HIS B 1 686 ? 107.796 89.977  102.110 1.00 38.10  ? 686 HIS B CD2 1 
ATOM 8384 C CE1 . HIS B 1 686 ? 108.687 89.159  100.281 1.00 36.41  ? 686 HIS B CE1 1 
ATOM 8385 N NE2 . HIS B 1 686 ? 107.540 89.404  100.888 1.00 36.73  ? 686 HIS B NE2 1 
ATOM 8386 N N   . ILE B 1 687 ? 112.248 89.940  105.863 1.00 50.57  ? 687 ILE B N   1 
ATOM 8387 C CA  . ILE B 1 687 ? 112.897 90.340  107.107 1.00 44.95  ? 687 ILE B CA  1 
ATOM 8388 C C   . ILE B 1 687 ? 114.174 91.096  106.770 1.00 46.23  ? 687 ILE B C   1 
ATOM 8389 O O   . ILE B 1 687 ? 114.973 90.635  105.949 1.00 41.02  ? 687 ILE B O   1 
ATOM 8390 C CB  . ILE B 1 687 ? 113.204 89.119  108.003 1.00 30.05  ? 687 ILE B CB  1 
ATOM 8391 C CG1 . ILE B 1 687 ? 111.957 88.689  108.770 1.00 32.24  ? 687 ILE B CG1 1 
ATOM 8392 C CG2 . ILE B 1 687 ? 114.323 89.408  108.996 1.00 27.24  ? 687 ILE B CG2 1 
ATOM 8393 C CD1 . ILE B 1 687 ? 112.171 87.449  109.611 1.00 38.73  ? 687 ILE B CD1 1 
ATOM 8394 N N   . VAL B 1 688 ? 114.363 92.259  107.391 1.00 43.20  ? 688 VAL B N   1 
ATOM 8395 C CA  . VAL B 1 688 ? 115.631 92.976  107.353 1.00 38.91  ? 688 VAL B CA  1 
ATOM 8396 C C   . VAL B 1 688 ? 116.294 92.840  108.717 1.00 42.45  ? 688 VAL B C   1 
ATOM 8397 O O   . VAL B 1 688 ? 115.623 92.582  109.724 1.00 43.78  ? 688 VAL B O   1 
ATOM 8398 C CB  . VAL B 1 688 ? 115.452 94.456  106.957 1.00 33.30  ? 688 VAL B CB  1 
ATOM 8399 C CG1 . VAL B 1 688 ? 114.474 94.573  105.808 1.00 39.55  ? 688 VAL B CG1 1 
ATOM 8400 C CG2 . VAL B 1 688 ? 114.994 95.295  108.136 1.00 34.89  ? 688 VAL B CG2 1 
ATOM 8401 N N   . ALA B 1 689 ? 117.617 92.975  108.739 1.00 40.36  ? 689 ALA B N   1 
ATOM 8402 C CA  . ALA B 1 689 ? 118.400 92.873  109.962 1.00 35.70  ? 689 ALA B CA  1 
ATOM 8403 C C   . ALA B 1 689 ? 119.725 93.587  109.746 1.00 42.90  ? 689 ALA B C   1 
ATOM 8404 O O   . ALA B 1 689 ? 120.054 94.002  108.634 1.00 44.70  ? 689 ALA B O   1 
ATOM 8405 C CB  . ALA B 1 689 ? 118.633 91.413  110.368 1.00 39.23  ? 689 ALA B CB  1 
ATOM 8406 N N   . CYS B 1 690 ? 120.487 93.742  110.823 1.00 50.83  ? 690 CYS B N   1 
ATOM 8407 C CA  . CYS B 1 690 ? 121.815 94.331  110.745 1.00 54.32  ? 690 CYS B CA  1 
ATOM 8408 C C   . CYS B 1 690 ? 122.858 93.293  111.137 1.00 49.64  ? 690 CYS B C   1 
ATOM 8409 O O   . CYS B 1 690 ? 122.557 92.317  111.830 1.00 57.64  ? 690 CYS B O   1 
ATOM 8410 C CB  . CYS B 1 690 ? 121.943 95.559  111.651 1.00 51.06  ? 690 CYS B CB  1 
ATOM 8411 S SG  . CYS B 1 690 ? 120.519 96.660  111.657 1.00 57.45  ? 690 CYS B SG  1 
ATOM 8412 N N   . ALA B 1 691 ? 124.095 93.514  110.693 1.00 41.73  ? 691 ALA B N   1 
ATOM 8413 C CA  . ALA B 1 691 ? 125.157 92.549  110.942 1.00 42.58  ? 691 ALA B CA  1 
ATOM 8414 C C   . ALA B 1 691 ? 125.751 92.652  112.340 1.00 37.55  ? 691 ALA B C   1 
ATOM 8415 O O   . ALA B 1 691 ? 126.595 91.822  112.691 1.00 37.82  ? 691 ALA B O   1 
ATOM 8416 C CB  . ALA B 1 691 ? 126.266 92.712  109.902 1.00 45.59  ? 691 ALA B CB  1 
ATOM 8417 N N   . LEU B 1 692 ? 125.349 93.636  113.140 1.00 42.09  ? 692 LEU B N   1 
ATOM 8418 C CA  . LEU B 1 692 ? 125.931 93.872  114.460 1.00 46.58  ? 692 LEU B CA  1 
ATOM 8419 C C   . LEU B 1 692 ? 124.851 93.867  115.537 1.00 45.39  ? 692 LEU B C   1 
ATOM 8420 O O   . LEU B 1 692 ? 124.834 94.709  116.438 1.00 49.08  ? 692 LEU B O   1 
ATOM 8421 C CB  . LEU B 1 692 ? 126.702 95.191  114.500 1.00 42.47  ? 692 LEU B CB  1 
ATOM 8422 C CG  . LEU B 1 692 ? 128.213 95.223  114.238 1.00 40.61  ? 692 LEU B CG  1 
ATOM 8423 C CD1 . LEU B 1 692 ? 128.970 94.574  115.387 1.00 45.07  ? 692 LEU B CD1 1 
ATOM 8424 C CD2 . LEU B 1 692 ? 128.600 94.595  112.906 1.00 41.33  ? 692 LEU B CD2 1 
ATOM 8425 N N   . ASP B 1 693 ? 123.930 92.907  115.464 1.00 38.43  ? 693 ASP B N   1 
ATOM 8426 C CA  . ASP B 1 693 ? 122.893 92.824  116.481 1.00 37.63  ? 693 ASP B CA  1 
ATOM 8427 C C   . ASP B 1 693 ? 123.029 91.545  117.295 1.00 45.82  ? 693 ASP B C   1 
ATOM 8428 O O   . ASP B 1 693 ? 123.527 90.533  116.795 1.00 53.48  ? 693 ASP B O   1 
ATOM 8429 C CB  . ASP B 1 693 ? 121.486 92.852  115.872 1.00 46.55  ? 693 ASP B CB  1 
ATOM 8430 C CG  . ASP B 1 693 ? 121.375 93.789  114.701 1.00 49.87  ? 693 ASP B CG  1 
ATOM 8431 O OD1 . ASP B 1 693 ? 121.996 94.869  114.756 1.00 51.56  ? 693 ASP B OD1 1 
ATOM 8432 O OD2 . ASP B 1 693 ? 120.647 93.454  113.743 1.00 43.42  ? 693 ASP B OD2 1 
ATOM 8433 N N   . PRO B 1 694 ? 122.612 91.565  118.564 1.00 40.47  ? 694 PRO B N   1 
ATOM 8434 C CA  . PRO B 1 694 ? 122.402 90.291  119.267 1.00 41.38  ? 694 PRO B CA  1 
ATOM 8435 C C   . PRO B 1 694 ? 121.299 89.462  118.639 1.00 53.44  ? 694 PRO B C   1 
ATOM 8436 O O   . PRO B 1 694 ? 121.370 88.227  118.648 1.00 64.56  ? 694 PRO B O   1 
ATOM 8437 C CB  . PRO B 1 694 ? 122.043 90.729  120.694 1.00 49.86  ? 694 PRO B CB  1 
ATOM 8438 C CG  . PRO B 1 694 ? 122.495 92.144  120.797 1.00 53.26  ? 694 PRO B CG  1 
ATOM 8439 C CD  . PRO B 1 694 ? 122.352 92.723  119.431 1.00 47.93  ? 694 PRO B CD  1 
ATOM 8440 N N   . MET B 1 695 ? 120.284 90.111  118.076 1.00 51.45  ? 695 MET B N   1 
ATOM 8441 C CA  . MET B 1 695 ? 119.218 89.422  117.352 1.00 45.05  ? 695 MET B CA  1 
ATOM 8442 C C   . MET B 1 695 ? 119.603 89.213  115.895 1.00 47.11  ? 695 MET B C   1 
ATOM 8443 O O   . MET B 1 695 ? 118.835 89.499  114.980 1.00 55.70  ? 695 MET B O   1 
ATOM 8444 C CB  . MET B 1 695 ? 117.920 90.211  117.457 1.00 47.62  ? 695 MET B CB  1 
ATOM 8445 C CG  . MET B 1 695 ? 117.391 90.383  118.864 1.00 50.22  ? 695 MET B CG  1 
ATOM 8446 S SD  . MET B 1 695 ? 117.398 88.855  119.808 1.00 48.38  ? 695 MET B SD  1 
ATOM 8447 C CE  . MET B 1 695 ? 116.465 89.358  121.246 1.00 51.97  ? 695 MET B CE  1 
ATOM 8448 N N   . LEU B 1 696 ? 120.808 88.703  115.669 1.00 36.46  ? 696 LEU B N   1 
ATOM 8449 C CA  . LEU B 1 696 ? 121.238 88.358  114.328 1.00 36.11  ? 696 LEU B CA  1 
ATOM 8450 C C   . LEU B 1 696 ? 121.217 86.859  114.102 1.00 43.48  ? 696 LEU B C   1 
ATOM 8451 O O   . LEU B 1 696 ? 120.661 86.415  113.101 1.00 53.60  ? 696 LEU B O   1 
ATOM 8452 C CB  . LEU B 1 696 ? 122.637 88.918  114.046 1.00 43.09  ? 696 LEU B CB  1 
ATOM 8453 C CG  . LEU B 1 696 ? 123.252 88.529  112.702 1.00 47.55  ? 696 LEU B CG  1 
ATOM 8454 C CD1 . LEU B 1 696 ? 122.369 88.978  111.547 1.00 37.67  ? 696 LEU B CD1 1 
ATOM 8455 C CD2 . LEU B 1 696 ? 124.621 89.155  112.573 1.00 50.63  ? 696 LEU B CD2 1 
ATOM 8456 N N   . ASP B 1 697 ? 121.742 86.071  115.050 1.00 47.36  ? 697 ASP B N   1 
ATOM 8457 C CA  . ASP B 1 697 ? 121.813 84.620  114.881 1.00 52.37  ? 697 ASP B CA  1 
ATOM 8458 C C   . ASP B 1 697 ? 120.424 84.001  114.844 1.00 52.34  ? 697 ASP B C   1 
ATOM 8459 O O   . ASP B 1 697 ? 120.211 82.962  114.210 1.00 52.11  ? 697 ASP B O   1 
ATOM 8460 C CB  . ASP B 1 697 ? 122.625 83.993  116.012 1.00 59.96  ? 697 ASP B CB  1 
ATOM 8461 C CG  . ASP B 1 697 ? 123.357 82.745  115.579 1.00 64.32  ? 697 ASP B CG  1 
ATOM 8462 O OD1 . ASP B 1 697 ? 123.905 82.033  116.448 1.00 61.20  ? 697 ASP B OD1 1 
ATOM 8463 O OD2 . ASP B 1 697 ? 123.399 82.490  114.359 1.00 65.14  ? 697 ASP B OD2 1 
ATOM 8464 N N   . ASP B 1 698 ? 119.472 84.624  115.531 1.00 66.31  ? 698 ASP B N   1 
ATOM 8465 C CA  . ASP B 1 698 ? 118.106 84.123  115.559 1.00 65.91  ? 698 ASP B CA  1 
ATOM 8466 C C   . ASP B 1 698 ? 117.396 84.377  114.236 1.00 52.67  ? 698 ASP B C   1 
ATOM 8467 O O   . ASP B 1 698 ? 116.650 83.523  113.746 1.00 54.72  ? 698 ASP B O   1 
ATOM 8468 C CB  . ASP B 1 698 ? 117.372 84.781  116.719 1.00 58.95  ? 698 ASP B CB  1 
ATOM 8469 C CG  . ASP B 1 698 ? 118.270 84.966  117.930 1.00 65.34  ? 698 ASP B CG  1 
ATOM 8470 O OD1 . ASP B 1 698 ? 118.948 83.992  118.320 1.00 63.05  ? 698 ASP B OD1 1 
ATOM 8471 O OD2 . ASP B 1 698 ? 118.313 86.080  118.483 1.00 63.39  ? 698 ASP B OD2 1 
ATOM 8472 N N   . SER B 1 699 ? 117.618 85.552  113.646 1.00 42.09  ? 699 SER B N   1 
ATOM 8473 C CA  . SER B 1 699 ? 116.973 85.885  112.382 1.00 42.16  ? 699 SER B CA  1 
ATOM 8474 C C   . SER B 1 699 ? 117.508 85.046  111.225 1.00 46.60  ? 699 SER B C   1 
ATOM 8475 O O   . SER B 1 699 ? 116.749 84.710  110.309 1.00 51.62  ? 699 SER B O   1 
ATOM 8476 C CB  . SER B 1 699 ? 117.146 87.374  112.087 1.00 46.11  ? 699 SER B CB  1 
ATOM 8477 O OG  . SER B 1 699 ? 116.718 87.686  110.775 1.00 54.87  ? 699 SER B OG  1 
ATOM 8478 N N   . VAL B 1 700 ? 118.803 84.715  111.229 1.00 63.61  ? 700 VAL B N   1 
ATOM 8479 C CA  . VAL B 1 700 ? 119.327 83.832  110.189 1.00 61.48  ? 700 VAL B CA  1 
ATOM 8480 C C   . VAL B 1 700 ? 118.923 82.384  110.470 1.00 60.20  ? 700 VAL B C   1 
ATOM 8481 O O   . VAL B 1 700 ? 118.703 81.598  109.540 1.00 58.67  ? 700 VAL B O   1 
ATOM 8482 C CB  . VAL B 1 700 ? 120.854 84.036  110.019 1.00 46.63  ? 700 VAL B CB  1 
ATOM 8483 C CG1 . VAL B 1 700 ? 121.597 83.707  111.242 1.00 46.71  ? 700 VAL B CG1 1 
ATOM 8484 C CG2 . VAL B 1 700 ? 121.433 83.214  108.902 1.00 57.73  ? 700 VAL B CG2 1 
ATOM 8485 N N   . MET B 1 701 ? 118.738 82.027  111.749 1.00 60.24  ? 701 MET B N   1 
ATOM 8486 C CA  . MET B 1 701 ? 118.171 80.715  112.070 1.00 60.35  ? 701 MET B CA  1 
ATOM 8487 C C   . MET B 1 701 ? 116.742 80.571  111.558 1.00 63.85  ? 701 MET B C   1 
ATOM 8488 O O   . MET B 1 701 ? 116.309 79.458  111.236 1.00 60.74  ? 701 MET B O   1 
ATOM 8489 C CB  . MET B 1 701 ? 118.196 80.461  113.579 1.00 56.23  ? 701 MET B CB  1 
ATOM 8490 C CG  . MET B 1 701 ? 119.346 79.596  114.050 1.00 64.05  ? 701 MET B CG  1 
ATOM 8491 S SD  . MET B 1 701 ? 119.435 78.020  113.176 1.00 61.91  ? 701 MET B SD  1 
ATOM 8492 C CE  . MET B 1 701 ? 118.476 76.963  114.254 1.00 58.20  ? 701 MET B CE  1 
ATOM 8493 N N   . LEU B 1 702 ? 115.998 81.678  111.484 1.00 64.35  ? 702 LEU B N   1 
ATOM 8494 C CA  . LEU B 1 702 ? 114.626 81.628  110.990 1.00 59.76  ? 702 LEU B CA  1 
ATOM 8495 C C   . LEU B 1 702 ? 114.582 81.256  109.515 1.00 56.86  ? 702 LEU B C   1 
ATOM 8496 O O   . LEU B 1 702 ? 113.707 80.497  109.087 1.00 61.24  ? 702 LEU B O   1 
ATOM 8497 C CB  . LEU B 1 702 ? 113.936 82.969  111.228 1.00 62.46  ? 702 LEU B CB  1 
ATOM 8498 C CG  . LEU B 1 702 ? 112.411 83.023  111.117 1.00 64.48  ? 702 LEU B CG  1 
ATOM 8499 C CD1 . LEU B 1 702 ? 111.758 81.749  111.643 1.00 61.07  ? 702 LEU B CD1 1 
ATOM 8500 C CD2 . LEU B 1 702 ? 111.886 84.245  111.848 1.00 58.91  ? 702 LEU B CD2 1 
ATOM 8501 N N   . ALA B 1 703 ? 115.516 81.781  108.720 1.00 66.71  ? 703 ALA B N   1 
ATOM 8502 C CA  . ALA B 1 703 ? 115.594 81.378  107.321 1.00 69.19  ? 703 ALA B CA  1 
ATOM 8503 C C   . ALA B 1 703 ? 116.022 79.923  107.179 1.00 75.85  ? 703 ALA B C   1 
ATOM 8504 O O   . ALA B 1 703 ? 115.597 79.247  106.237 1.00 78.56  ? 703 ALA B O   1 
ATOM 8505 C CB  . ALA B 1 703 ? 116.551 82.293  106.560 1.00 72.16  ? 703 ALA B CB  1 
ATOM 8506 N N   . ARG B 1 704 ? 116.860 79.428  108.099 1.00 72.90  ? 704 ARG B N   1 
ATOM 8507 C CA  . ARG B 1 704 ? 117.286 78.031  108.053 1.00 71.44  ? 704 ARG B CA  1 
ATOM 8508 C C   . ARG B 1 704 ? 116.120 77.079  108.290 1.00 71.67  ? 704 ARG B C   1 
ATOM 8509 O O   . ARG B 1 704 ? 116.006 76.049  107.616 1.00 76.51  ? 704 ARG B O   1 
ATOM 8510 C CB  . ARG B 1 704 ? 118.387 77.774  109.084 1.00 68.06  ? 704 ARG B CB  1 
ATOM 8511 C CG  . ARG B 1 704 ? 119.653 78.583  108.881 1.00 71.95  ? 704 ARG B CG  1 
ATOM 8512 C CD  . ARG B 1 704 ? 120.868 77.891  109.478 1.00 74.56  ? 704 ARG B CD  1 
ATOM 8513 N NE  . ARG B 1 704 ? 121.665 77.216  108.461 1.00 71.27  ? 704 ARG B NE  1 
ATOM 8514 C CZ  . ARG B 1 704 ? 121.642 75.911  108.235 1.00 71.93  ? 704 ARG B CZ  1 
ATOM 8515 N NH1 . ARG B 1 704 ? 120.873 75.100  108.942 1.00 68.22  ? 704 ARG B NH1 1 
ATOM 8516 N NH2 . ARG B 1 704 ? 122.410 75.405  107.274 1.00 71.94  ? 704 ARG B NH2 1 
ATOM 8517 N N   . ARG B 1 705 ? 115.246 77.404  109.241 1.00 69.30  ? 705 ARG B N   1 
ATOM 8518 C CA  . ARG B 1 705 ? 114.146 76.516  109.588 1.00 69.86  ? 705 ARG B CA  1 
ATOM 8519 C C   . ARG B 1 705 ? 112.995 76.564  108.594 1.00 66.75  ? 705 ARG B C   1 
ATOM 8520 O O   . ARG B 1 705 ? 112.093 75.727  108.685 1.00 71.41  ? 705 ARG B O   1 
ATOM 8521 C CB  . ARG B 1 705 ? 113.629 76.843  110.988 1.00 67.84  ? 705 ARG B CB  1 
ATOM 8522 C CG  . ARG B 1 705 ? 114.425 76.182  112.094 1.00 71.66  ? 705 ARG B CG  1 
ATOM 8523 C CD  . ARG B 1 705 ? 113.839 74.838  112.472 1.00 75.46  ? 705 ARG B CD  1 
ATOM 8524 N NE  . ARG B 1 705 ? 112.492 74.959  113.012 1.00 70.80  ? 705 ARG B NE  1 
ATOM 8525 C CZ  . ARG B 1 705 ? 111.401 74.517  112.403 1.00 71.57  ? 705 ARG B CZ  1 
ATOM 8526 N NH1 . ARG B 1 705 ? 111.460 73.934  111.217 1.00 71.88  ? 705 ARG B NH1 1 
ATOM 8527 N NH2 . ARG B 1 705 ? 110.221 74.663  112.998 1.00 70.26  ? 705 ARG B NH2 1 
ATOM 8528 N N   . LEU B 1 706 ? 112.998 77.510  107.653 1.00 62.52  ? 706 LEU B N   1 
ATOM 8529 C CA  . LEU B 1 706 ? 111.955 77.591  106.642 1.00 70.64  ? 706 LEU B CA  1 
ATOM 8530 C C   . LEU B 1 706 ? 112.433 77.314  105.225 1.00 71.41  ? 706 LEU B C   1 
ATOM 8531 O O   . LEU B 1 706 ? 111.595 77.041  104.360 1.00 71.73  ? 706 LEU B O   1 
ATOM 8532 C CB  . LEU B 1 706 ? 111.274 78.970  106.673 1.00 70.84  ? 706 LEU B CB  1 
ATOM 8533 C CG  . LEU B 1 706 ? 110.806 79.483  108.038 1.00 71.05  ? 706 LEU B CG  1 
ATOM 8534 C CD1 . LEU B 1 706 ? 110.101 80.823  107.912 1.00 64.91  ? 706 LEU B CD1 1 
ATOM 8535 C CD2 . LEU B 1 706 ? 109.898 78.470  108.716 1.00 69.64  ? 706 LEU B CD2 1 
ATOM 8536 N N   . ARG B 1 707 ? 113.739 77.373  104.956 1.00 73.23  ? 707 ARG B N   1 
ATOM 8537 C CA  . ARG B 1 707 ? 114.228 77.042  103.623 1.00 77.80  ? 707 ARG B CA  1 
ATOM 8538 C C   . ARG B 1 707 ? 114.299 75.541  103.379 1.00 82.67  ? 707 ARG B C   1 
ATOM 8539 O O   . ARG B 1 707 ? 114.390 75.119  102.222 1.00 78.87  ? 707 ARG B O   1 
ATOM 8540 C CB  . ARG B 1 707 ? 115.604 77.666  103.382 1.00 78.46  ? 707 ARG B CB  1 
ATOM 8541 C CG  . ARG B 1 707 ? 115.563 79.128  102.956 1.00 79.76  ? 707 ARG B CG  1 
ATOM 8542 C CD  . ARG B 1 707 ? 114.514 79.376  101.882 1.00 77.90  ? 707 ARG B CD  1 
ATOM 8543 N NE  . ARG B 1 707 ? 115.088 79.368  100.543 1.00 78.76  ? 707 ARG B NE  1 
ATOM 8544 C CZ  . ARG B 1 707 ? 115.594 80.435  99.940  1.00 83.49  ? 707 ARG B CZ  1 
ATOM 8545 N NH1 . ARG B 1 707 ? 115.620 81.616  100.534 1.00 84.47  ? 707 ARG B NH1 1 
ATOM 8546 N NH2 . ARG B 1 707 ? 116.087 80.313  98.711  1.00 79.89  ? 707 ARG B NH2 1 
ATOM 8547 N N   . ASN B 1 708 ? 114.260 74.729  104.433 1.00 86.41  ? 708 ASN B N   1 
ATOM 8548 C CA  . ASN B 1 708 ? 114.188 73.282  104.292 1.00 83.20  ? 708 ASN B CA  1 
ATOM 8549 C C   . ASN B 1 708 ? 112.755 72.772  104.223 1.00 87.24  ? 708 ASN B C   1 
ATOM 8550 O O   . ASN B 1 708 ? 112.545 71.556  104.167 1.00 92.98  ? 708 ASN B O   1 
ATOM 8551 C CB  . ASN B 1 708 ? 114.935 72.593  105.443 1.00 83.52  ? 708 ASN B CB  1 
ATOM 8552 C CG  . ASN B 1 708 ? 114.669 73.242  106.788 1.00 84.93  ? 708 ASN B CG  1 
ATOM 8553 O OD1 . ASN B 1 708 ? 113.691 73.967  106.959 1.00 85.65  ? 708 ASN B OD1 1 
ATOM 8554 N ND2 . ASN B 1 708 ? 115.543 72.980  107.753 1.00 80.93  ? 708 ASN B ND2 1 
ATOM 8555 N N   . LEU B 1 709 ? 111.767 73.672  104.231 1.00 76.25  ? 709 LEU B N   1 
ATOM 8556 C CA  . LEU B 1 709 ? 110.366 73.297  104.122 1.00 75.89  ? 709 LEU B CA  1 
ATOM 8557 C C   . LEU B 1 709 ? 109.720 73.719  102.811 1.00 75.63  ? 709 LEU B C   1 
ATOM 8558 O O   . LEU B 1 709 ? 108.603 73.278  102.525 1.00 75.99  ? 709 LEU B O   1 
ATOM 8559 C CB  . LEU B 1 709 ? 109.559 73.902  105.279 1.00 75.69  ? 709 LEU B CB  1 
ATOM 8560 C CG  . LEU B 1 709 ? 110.154 73.777  106.679 1.00 70.16  ? 709 LEU B CG  1 
ATOM 8561 C CD1 . LEU B 1 709 ? 109.239 74.443  107.686 1.00 75.22  ? 709 LEU B CD1 1 
ATOM 8562 C CD2 . LEU B 1 709 ? 110.379 72.320  107.034 1.00 71.66  ? 709 LEU B CD2 1 
ATOM 8563 N N   . GLY B 1 710 ? 110.383 74.557  102.018 1.00 68.34  ? 710 GLY B N   1 
ATOM 8564 C CA  . GLY B 1 710 ? 109.853 75.032  100.762 1.00 71.92  ? 710 GLY B CA  1 
ATOM 8565 C C   . GLY B 1 710 ? 109.205 76.399  100.827 1.00 75.41  ? 710 GLY B C   1 
ATOM 8566 O O   . GLY B 1 710 ? 108.975 77.010  99.776  1.00 80.06  ? 710 GLY B O   1 
ATOM 8567 N N   . GLN B 1 711 ? 108.903 76.891  102.022 1.00 70.90  ? 711 GLN B N   1 
ATOM 8568 C CA  . GLN B 1 711 ? 108.317 78.218  102.154 1.00 68.88  ? 711 GLN B CA  1 
ATOM 8569 C C   . GLN B 1 711 ? 109.381 79.276  101.883 1.00 70.45  ? 711 GLN B C   1 
ATOM 8570 O O   . GLN B 1 711 ? 110.466 79.219  102.472 1.00 68.47  ? 711 GLN B O   1 
ATOM 8571 C CB  . GLN B 1 711 ? 107.727 78.410  103.548 1.00 65.66  ? 711 GLN B CB  1 
ATOM 8572 C CG  . GLN B 1 711 ? 106.837 79.636  103.673 1.00 68.91  ? 711 GLN B CG  1 
ATOM 8573 C CD  . GLN B 1 711 ? 107.584 80.853  104.176 1.00 68.69  ? 711 GLN B CD  1 
ATOM 8574 O OE1 . GLN B 1 711 ? 108.259 80.801  105.201 1.00 68.18  ? 711 GLN B OE1 1 
ATOM 8575 N NE2 . GLN B 1 711 ? 107.471 81.957  103.449 1.00 64.19  ? 711 GLN B NE2 1 
ATOM 8576 N N   . PRO B 1 712 ? 109.118 80.248  101.008 1.00 73.78  ? 712 PRO B N   1 
ATOM 8577 C CA  . PRO B 1 712 ? 110.133 81.267  100.702 1.00 74.56  ? 712 PRO B CA  1 
ATOM 8578 C C   . PRO B 1 712 ? 110.151 82.361  101.761 1.00 73.70  ? 712 PRO B C   1 
ATOM 8579 O O   . PRO B 1 712 ? 109.120 82.963  102.069 1.00 74.92  ? 712 PRO B O   1 
ATOM 8580 C CB  . PRO B 1 712 ? 109.692 81.809  99.337  1.00 75.51  ? 712 PRO B CB  1 
ATOM 8581 C CG  . PRO B 1 712 ? 108.223 81.533  99.260  1.00 72.54  ? 712 PRO B CG  1 
ATOM 8582 C CD  . PRO B 1 712 ? 107.878 80.437  100.234 1.00 68.81  ? 712 PRO B CD  1 
ATOM 8583 N N   . VAL B 1 713 ? 111.329 82.610  102.326 1.00 55.60  ? 713 VAL B N   1 
ATOM 8584 C CA  . VAL B 1 713 ? 111.558 83.733  103.227 1.00 48.66  ? 713 VAL B CA  1 
ATOM 8585 C C   . VAL B 1 713 ? 112.838 84.431  102.788 1.00 55.75  ? 713 VAL B C   1 
ATOM 8586 O O   . VAL B 1 713 ? 113.841 83.773  102.491 1.00 61.51  ? 713 VAL B O   1 
ATOM 8587 C CB  . VAL B 1 713 ? 111.624 83.288  104.705 1.00 53.52  ? 713 VAL B CB  1 
ATOM 8588 C CG1 . VAL B 1 713 ? 112.614 82.149  104.907 1.00 58.16  ? 713 VAL B CG1 1 
ATOM 8589 C CG2 . VAL B 1 713 ? 111.966 84.460  105.614 1.00 48.39  ? 713 VAL B CG2 1 
ATOM 8590 N N   . THR B 1 714 ? 112.787 85.755  102.692 1.00 53.39  ? 714 THR B N   1 
ATOM 8591 C CA  . THR B 1 714 ? 113.928 86.555  102.273 1.00 57.47  ? 714 THR B CA  1 
ATOM 8592 C C   . THR B 1 714 ? 114.481 87.303  103.477 1.00 49.17  ? 714 THR B C   1 
ATOM 8593 O O   . THR B 1 714 ? 113.722 87.909  104.240 1.00 53.77  ? 714 THR B O   1 
ATOM 8594 C CB  . THR B 1 714 ? 113.538 87.540  101.168 1.00 55.82  ? 714 THR B CB  1 
ATOM 8595 O OG1 . THR B 1 714 ? 112.730 86.872  100.192 1.00 58.29  ? 714 THR B OG1 1 
ATOM 8596 C CG2 . THR B 1 714 ? 114.779 88.087  100.485 1.00 50.33  ? 714 THR B CG2 1 
ATOM 8597 N N   . LEU B 1 715 ? 115.797 87.248  103.650 1.00 43.68  ? 715 LEU B N   1 
ATOM 8598 C CA  . LEU B 1 715 ? 116.480 87.950  104.725 1.00 51.51  ? 715 LEU B CA  1 
ATOM 8599 C C   . LEU B 1 715 ? 117.481 88.922  104.122 1.00 60.44  ? 715 LEU B C   1 
ATOM 8600 O O   . LEU B 1 715 ? 118.314 88.530  103.299 1.00 64.96  ? 715 LEU B O   1 
ATOM 8601 C CB  . LEU B 1 715 ? 117.186 86.970  105.665 1.00 56.53  ? 715 LEU B CB  1 
ATOM 8602 C CG  . LEU B 1 715 ? 118.336 87.515  106.513 1.00 52.65  ? 715 LEU B CG  1 
ATOM 8603 C CD1 . LEU B 1 715 ? 117.807 88.308  107.690 1.00 49.94  ? 715 LEU B CD1 1 
ATOM 8604 C CD2 . LEU B 1 715 ? 119.218 86.381  106.996 1.00 48.31  ? 715 LEU B CD2 1 
ATOM 8605 N N   . ARG B 1 716 ? 117.390 90.185  104.523 1.00 60.12  ? 716 ARG B N   1 
ATOM 8606 C CA  . ARG B 1 716 ? 118.338 91.211  104.122 1.00 58.37  ? 716 ARG B CA  1 
ATOM 8607 C C   . ARG B 1 716 ? 119.131 91.662  105.338 1.00 53.02  ? 716 ARG B C   1 
ATOM 8608 O O   . ARG B 1 716 ? 118.581 91.794  106.436 1.00 48.29  ? 716 ARG B O   1 
ATOM 8609 C CB  . ARG B 1 716 ? 117.633 92.410  103.483 1.00 59.25  ? 716 ARG B CB  1 
ATOM 8610 C CG  . ARG B 1 716 ? 117.276 92.215  102.022 1.00 58.83  ? 716 ARG B CG  1 
ATOM 8611 C CD  . ARG B 1 716 ? 118.489 92.419  101.129 1.00 56.95  ? 716 ARG B CD  1 
ATOM 8612 N NE  . ARG B 1 716 ? 119.444 93.362  101.701 1.00 55.33  ? 716 ARG B NE  1 
ATOM 8613 C CZ  . ARG B 1 716 ? 119.698 94.565  101.205 1.00 59.63  ? 716 ARG B CZ  1 
ATOM 8614 N NH1 . ARG B 1 716 ? 119.088 95.009  100.119 1.00 59.39  ? 716 ARG B NH1 1 
ATOM 8615 N NH2 . ARG B 1 716 ? 120.591 95.341  101.813 1.00 60.08  ? 716 ARG B NH2 1 
ATOM 8616 N N   . VAL B 1 717 ? 120.424 91.890  105.142 1.00 57.94  ? 717 VAL B N   1 
ATOM 8617 C CA  . VAL B 1 717 ? 121.319 92.292  106.217 1.00 58.50  ? 717 VAL B CA  1 
ATOM 8618 C C   . VAL B 1 717 ? 121.960 93.621  105.838 1.00 50.64  ? 717 VAL B C   1 
ATOM 8619 O O   . VAL B 1 717 ? 122.202 93.891  104.655 0.84 55.34  ? 717 VAL B O   1 
ATOM 8620 C CB  . VAL B 1 717 ? 122.367 91.200  106.525 1.00 57.48  ? 717 VAL B CB  1 
ATOM 8621 C CG1 . VAL B 1 717 ? 123.445 91.108  105.448 1.00 56.70  ? 717 VAL B CG1 1 
ATOM 8622 C CG2 . VAL B 1 717 ? 122.985 91.421  107.901 1.00 51.21  ? 717 VAL B CG2 1 
ATOM 8623 N N   . VAL B 1 718 ? 122.148 94.484  106.831 1.00 45.54  ? 718 VAL B N   1 
ATOM 8624 C CA  . VAL B 1 718 ? 122.883 95.725  106.657 1.00 54.98  ? 718 VAL B CA  1 
ATOM 8625 C C   . VAL B 1 718 ? 124.019 95.749  107.675 1.00 63.88  ? 718 VAL B C   1 
ATOM 8626 O O   . VAL B 1 718 ? 124.138 94.871  108.528 1.00 62.79  ? 718 VAL B O   1 
ATOM 8627 C CB  . VAL B 1 718 ? 121.978 96.968  106.785 1.00 54.49  ? 718 VAL B CB  1 
ATOM 8628 C CG1 . VAL B 1 718 ? 120.974 97.018  105.640 1.00 52.95  ? 718 VAL B CG1 1 
ATOM 8629 C CG2 . VAL B 1 718 ? 121.273 96.984  108.124 1.00 55.27  ? 718 VAL B CG2 1 
ATOM 8630 N N   . GLU B 1 719 ? 124.868 96.767  107.573 1.00 66.05  ? 719 GLU B N   1 
ATOM 8631 C CA  . GLU B 1 719 ? 126.093 96.819  108.356 1.00 63.31  ? 719 GLU B CA  1 
ATOM 8632 C C   . GLU B 1 719 ? 126.303 98.219  108.918 1.00 56.72  ? 719 GLU B C   1 
ATOM 8633 O O   . GLU B 1 719 ? 125.641 99.181  108.519 1.00 61.10  ? 719 GLU B O   1 
ATOM 8634 C CB  . GLU B 1 719 ? 127.301 96.392  107.512 1.00 63.60  ? 719 GLU B CB  1 
ATOM 8635 C CG  . GLU B 1 719 ? 127.517 97.239  106.269 1.00 65.11  ? 719 GLU B CG  1 
ATOM 8636 C CD  . GLU B 1 719 ? 126.841 96.660  105.039 1.00 66.67  ? 719 GLU B CD  1 
ATOM 8637 O OE1 . GLU B 1 719 ? 125.962 95.787  105.193 1.00 68.39  ? 719 GLU B OE1 1 
ATOM 8638 O OE2 . GLU B 1 719 ? 127.191 97.078  103.914 1.00 69.61  ? 719 GLU B OE2 1 
ATOM 8639 N N   . ASP B 1 720 ? 127.227 98.302  109.878 1.00 61.78  ? 720 ASP B N   1 
ATOM 8640 C CA  . ASP B 1 720 ? 127.702 99.524  110.526 1.00 71.21  ? 720 ASP B CA  1 
ATOM 8641 C C   . ASP B 1 720 ? 126.620 100.251 111.317 1.00 70.19  ? 720 ASP B C   1 
ATOM 8642 O O   . ASP B 1 720 ? 126.786 101.433 111.636 1.00 74.61  ? 720 ASP B O   1 
ATOM 8643 C CB  . ASP B 1 720 ? 128.339 100.493 109.516 1.00 74.97  ? 720 ASP B CB  1 
ATOM 8644 C CG  . ASP B 1 720 ? 129.757 100.105 109.145 1.00 71.36  ? 720 ASP B CG  1 
ATOM 8645 O OD1 . ASP B 1 720 ? 130.412 99.396  109.939 1.00 71.32  ? 720 ASP B OD1 1 
ATOM 8646 O OD2 . ASP B 1 720 ? 130.218 100.510 108.057 1.00 68.18  ? 720 ASP B OD2 1 
ATOM 8647 N N   . LEU B 1 721 ? 125.518 99.585  111.647 1.00 64.78  ? 721 LEU B N   1 
ATOM 8648 C CA  . LEU B 1 721 ? 124.439 100.193 112.409 1.00 66.40  ? 721 LEU B CA  1 
ATOM 8649 C C   . LEU B 1 721 ? 124.012 99.255  113.527 1.00 59.93  ? 721 LEU B C   1 
ATOM 8650 O O   . LEU B 1 721 ? 124.118 98.033  113.386 1.00 58.57  ? 721 LEU B O   1 
ATOM 8651 C CB  . LEU B 1 721 ? 123.226 100.499 111.513 1.00 60.27  ? 721 LEU B CB  1 
ATOM 8652 C CG  . LEU B 1 721 ? 123.462 101.088 110.124 1.00 59.54  ? 721 LEU B CG  1 
ATOM 8653 C CD1 . LEU B 1 721 ? 122.332 100.710 109.202 1.00 53.93  ? 721 LEU B CD1 1 
ATOM 8654 C CD2 . LEU B 1 721 ? 123.610 102.589 110.191 1.00 60.03  ? 721 LEU B CD2 1 
ATOM 8655 N N   . PRO B 1 722 ? 123.521 99.788  114.639 1.00 45.22  ? 722 PRO B N   1 
ATOM 8656 C CA  . PRO B 1 722 ? 122.945 98.935  115.680 1.00 48.39  ? 722 PRO B CA  1 
ATOM 8657 C C   . PRO B 1 722 ? 121.528 98.520  115.295 1.00 51.64  ? 722 PRO B C   1 
ATOM 8658 O O   . PRO B 1 722 ? 121.032 98.830  114.215 1.00 48.67  ? 722 PRO B O   1 
ATOM 8659 C CB  . PRO B 1 722 ? 122.956 99.835  116.915 1.00 44.21  ? 722 PRO B CB  1 
ATOM 8660 C CG  . PRO B 1 722 ? 122.840 101.204 116.377 1.00 35.09  ? 722 PRO B CG  1 
ATOM 8661 C CD  . PRO B 1 722 ? 123.494 101.211 115.022 1.00 38.22  ? 722 PRO B CD  1 
ATOM 8662 N N   . HIS B 1 723 ? 120.878 97.800  116.201 1.00 43.61  ? 723 HIS B N   1 
ATOM 8663 C CA  . HIS B 1 723 ? 119.468 97.485  116.046 1.00 43.28  ? 723 HIS B CA  1 
ATOM 8664 C C   . HIS B 1 723 ? 118.663 98.375  116.985 1.00 51.90  ? 723 HIS B C   1 
ATOM 8665 O O   . HIS B 1 723 ? 119.076 98.642  118.117 1.00 54.10  ? 723 HIS B O   1 
ATOM 8666 C CB  . HIS B 1 723 ? 119.191 96.002  116.306 1.00 45.35  ? 723 HIS B CB  1 
ATOM 8667 C CG  . HIS B 1 723 ? 118.804 95.687  117.715 1.00 48.81  ? 723 HIS B CG  1 
ATOM 8668 N ND1 . HIS B 1 723 ? 119.708 95.703  118.754 1.00 56.48  ? 723 HIS B ND1 1 
ATOM 8669 C CD2 . HIS B 1 723 ? 117.614 95.338  118.255 1.00 51.27  ? 723 HIS B CD2 1 
ATOM 8670 C CE1 . HIS B 1 723 ? 119.090 95.379  119.875 1.00 56.67  ? 723 HIS B CE1 1 
ATOM 8671 N NE2 . HIS B 1 723 ? 117.818 95.155  119.600 1.00 59.61  ? 723 HIS B NE2 1 
ATOM 8672 N N   . GLY B 1 724 ? 117.528 98.850  116.494 1.00 52.31  ? 724 GLY B N   1 
ATOM 8673 C CA  . GLY B 1 724 ? 116.832 99.956  117.107 1.00 49.45  ? 724 GLY B CA  1 
ATOM 8674 C C   . GLY B 1 724 ? 116.868 101.236 116.305 1.00 48.71  ? 724 GLY B C   1 
ATOM 8675 O O   . GLY B 1 724 ? 116.658 102.308 116.882 1.00 54.18  ? 724 GLY B O   1 
ATOM 8676 N N   . PHE B 1 725 ? 117.110 101.158 114.998 1.00 45.96  ? 725 PHE B N   1 
ATOM 8677 C CA  . PHE B 1 725 ? 117.337 102.334 114.169 1.00 46.76  ? 725 PHE B CA  1 
ATOM 8678 C C   . PHE B 1 725 ? 116.083 102.833 113.461 1.00 54.43  ? 725 PHE B C   1 
ATOM 8679 O O   . PHE B 1 725 ? 116.167 103.814 112.716 1.00 43.84  ? 725 PHE B O   1 
ATOM 8680 C CB  . PHE B 1 725 ? 118.422 102.039 113.124 1.00 33.95  ? 725 PHE B CB  1 
ATOM 8681 C CG  . PHE B 1 725 ? 118.005 101.049 112.071 1.00 31.63  ? 725 PHE B CG  1 
ATOM 8682 C CD1 . PHE B 1 725 ? 118.120 99.689  112.293 1.00 33.16  ? 725 PHE B CD1 1 
ATOM 8683 C CD2 . PHE B 1 725 ? 117.533 101.483 110.841 1.00 35.07  ? 725 PHE B CD2 1 
ATOM 8684 C CE1 . PHE B 1 725 ? 117.739 98.781  111.323 1.00 34.86  ? 725 PHE B CE1 1 
ATOM 8685 C CE2 . PHE B 1 725 ? 117.153 100.581 109.873 1.00 39.44  ? 725 PHE B CE2 1 
ATOM 8686 C CZ  . PHE B 1 725 ? 117.261 99.228  110.111 1.00 41.68  ? 725 PHE B CZ  1 
ATOM 8687 N N   . LEU B 1 726 ? 114.935 102.178 113.647 1.00 47.54  ? 726 LEU B N   1 
ATOM 8688 C CA  . LEU B 1 726 ? 113.734 102.604 112.937 1.00 39.15  ? 726 LEU B CA  1 
ATOM 8689 C C   . LEU B 1 726 ? 113.203 103.925 113.477 1.00 43.64  ? 726 LEU B C   1 
ATOM 8690 O O   . LEU B 1 726 ? 112.626 104.715 112.722 1.00 45.83  ? 726 LEU B O   1 
ATOM 8691 C CB  . LEU B 1 726 ? 112.666 101.516 113.014 1.00 48.30  ? 726 LEU B CB  1 
ATOM 8692 C CG  . LEU B 1 726 ? 112.660 100.558 111.822 1.00 46.41  ? 726 LEU B CG  1 
ATOM 8693 C CD1 . LEU B 1 726 ? 111.549 99.535  111.945 1.00 44.11  ? 726 LEU B CD1 1 
ATOM 8694 C CD2 . LEU B 1 726 ? 112.524 101.335 110.526 1.00 45.41  ? 726 LEU B CD2 1 
ATOM 8695 N N   . THR B 1 727 ? 113.404 104.189 114.765 1.00 49.13  ? 727 THR B N   1 
ATOM 8696 C CA  . THR B 1 727 ? 113.042 105.463 115.370 1.00 58.96  ? 727 THR B CA  1 
ATOM 8697 C C   . THR B 1 727 ? 114.118 106.521 115.186 1.00 62.76  ? 727 THR B C   1 
ATOM 8698 O O   . THR B 1 727 ? 113.940 107.656 115.640 1.00 66.55  ? 727 THR B O   1 
ATOM 8699 C CB  . THR B 1 727 ? 112.772 105.272 116.860 1.00 57.84  ? 727 THR B CB  1 
ATOM 8700 O OG1 . THR B 1 727 ? 114.015 105.264 117.571 1.00 56.82  ? 727 THR B OG1 1 
ATOM 8701 C CG2 . THR B 1 727 ? 112.087 103.954 117.083 1.00 58.39  ? 727 THR B CG2 1 
ATOM 8702 N N   . LEU B 1 728 ? 115.219 106.168 114.538 1.00 48.95  ? 728 LEU B N   1 
ATOM 8703 C CA  . LEU B 1 728 ? 116.393 107.011 114.376 1.00 42.20  ? 728 LEU B CA  1 
ATOM 8704 C C   . LEU B 1 728 ? 116.689 107.171 112.884 1.00 45.96  ? 728 LEU B C   1 
ATOM 8705 O O   . LEU B 1 728 ? 117.833 107.253 112.443 1.00 48.96  ? 728 LEU B O   1 
ATOM 8706 C CB  . LEU B 1 728 ? 117.538 106.416 115.204 1.00 42.65  ? 728 LEU B CB  1 
ATOM 8707 C CG  . LEU B 1 728 ? 119.043 106.653 115.361 1.00 44.77  ? 728 LEU B CG  1 
ATOM 8708 C CD1 . LEU B 1 728 ? 119.400 106.167 116.739 1.00 43.34  ? 728 LEU B CD1 1 
ATOM 8709 C CD2 . LEU B 1 728 ? 119.861 105.845 114.382 1.00 38.92  ? 728 LEU B CD2 1 
ATOM 8710 N N   . ALA B 1 729 ? 115.615 107.248 112.094 1.00 56.41  ? 729 ALA B N   1 
ATOM 8711 C CA  . ALA B 1 729 ? 115.733 107.245 110.639 1.00 56.89  ? 729 ALA B CA  1 
ATOM 8712 C C   . ALA B 1 729 ? 116.339 108.540 110.116 1.00 56.51  ? 729 ALA B C   1 
ATOM 8713 O O   . ALA B 1 729 ? 117.262 108.517 109.294 1.00 54.07  ? 729 ALA B O   1 
ATOM 8714 C CB  . ALA B 1 729 ? 114.361 107.012 110.010 1.00 55.61  ? 729 ALA B CB  1 
ATOM 8715 N N   . ALA B 1 730 ? 115.836 109.684 110.584 1.00 49.63  ? 730 ALA B N   1 
ATOM 8716 C CA  . ALA B 1 730 ? 116.211 110.987 110.049 1.00 47.39  ? 730 ALA B CA  1 
ATOM 8717 C C   . ALA B 1 730 ? 117.317 111.653 110.849 1.00 52.94  ? 730 ALA B C   1 
ATOM 8718 O O   . ALA B 1 730 ? 117.318 112.882 110.998 1.00 59.47  ? 730 ALA B O   1 
ATOM 8719 C CB  . ALA B 1 730 ? 114.987 111.899 109.979 1.00 51.72  ? 730 ALA B CB  1 
ATOM 8720 N N   . LEU B 1 731 ? 118.252 110.875 111.382 1.00 49.63  ? 731 LEU B N   1 
ATOM 8721 C CA  . LEU B 1 731 ? 119.311 111.397 112.233 1.00 49.29  ? 731 LEU B CA  1 
ATOM 8722 C C   . LEU B 1 731 ? 120.696 111.252 111.631 1.00 48.70  ? 731 LEU B C   1 
ATOM 8723 O O   . LEU B 1 731 ? 121.547 112.120 111.832 1.00 58.67  ? 731 LEU B O   1 
ATOM 8724 C CB  . LEU B 1 731 ? 119.263 110.699 113.593 1.00 50.78  ? 731 LEU B CB  1 
ATOM 8725 C CG  . LEU B 1 731 ? 120.255 111.154 114.651 1.00 56.16  ? 731 LEU B CG  1 
ATOM 8726 C CD1 . LEU B 1 731 ? 119.483 111.559 115.879 1.00 51.20  ? 731 LEU B CD1 1 
ATOM 8727 C CD2 . LEU B 1 731 ? 121.233 110.038 114.960 1.00 52.60  ? 731 LEU B CD2 1 
ATOM 8728 N N   . CYS B 1 732 ? 120.942 110.187 110.881 1.00 45.98  ? 732 CYS B N   1 
ATOM 8729 C CA  . CYS B 1 732 ? 122.225 109.972 110.236 1.00 46.38  ? 732 CYS B CA  1 
ATOM 8730 C C   . CYS B 1 732 ? 122.018 109.785 108.740 1.00 50.38  ? 732 CYS B C   1 
ATOM 8731 O O   . CYS B 1 732 ? 120.900 109.591 108.259 1.00 54.71  ? 732 CYS B O   1 
ATOM 8732 C CB  . CYS B 1 732 ? 122.945 108.760 110.838 1.00 55.59  ? 732 CYS B CB  1 
ATOM 8733 S SG  . CYS B 1 732 ? 124.140 107.980 109.738 1.00 72.50  ? 732 CYS B SG  1 
ATOM 8734 N N   . ARG B 1 733 ? 123.120 109.864 107.999 1.00 56.72  ? 733 ARG B N   1 
ATOM 8735 C CA  . ARG B 1 733 ? 123.067 109.684 106.556 1.00 56.11  ? 733 ARG B CA  1 
ATOM 8736 C C   . ARG B 1 733 ? 123.035 108.218 106.152 1.00 58.29  ? 733 ARG B C   1 
ATOM 8737 O O   . ARG B 1 733 ? 122.735 107.917 104.992 1.00 60.26  ? 733 ARG B O   1 
ATOM 8738 C CB  . ARG B 1 733 ? 124.263 110.375 105.898 1.00 61.17  ? 733 ARG B CB  1 
ATOM 8739 C CG  . ARG B 1 733 ? 125.551 109.571 105.964 1.00 60.92  ? 733 ARG B CG  1 
ATOM 8740 C CD  . ARG B 1 733 ? 126.754 110.403 105.566 1.00 62.05  ? 733 ARG B CD  1 
ATOM 8741 N NE  . ARG B 1 733 ? 127.997 109.799 106.030 1.00 65.36  ? 733 ARG B NE  1 
ATOM 8742 C CZ  . ARG B 1 733 ? 128.799 110.341 106.936 1.00 69.98  ? 733 ARG B CZ  1 
ATOM 8743 N NH1 . ARG B 1 733 ? 128.522 111.508 107.494 1.00 67.66  ? 733 ARG B NH1 1 
ATOM 8744 N NH2 . ARG B 1 733 ? 129.908 109.696 107.290 1.00 66.71  ? 733 ARG B NH2 1 
ATOM 8745 N N   . GLU B 1 734 ? 123.344 107.303 107.074 1.00 60.25  ? 734 GLU B N   1 
ATOM 8746 C CA  . GLU B 1 734 ? 123.345 105.877 106.783 1.00 57.86  ? 734 GLU B CA  1 
ATOM 8747 C C   . GLU B 1 734 ? 122.115 105.150 107.303 1.00 58.61  ? 734 GLU B C   1 
ATOM 8748 O O   . GLU B 1 734 ? 121.765 104.100 106.756 1.00 61.56  ? 734 GLU B O   1 
ATOM 8749 C CB  . GLU B 1 734 ? 124.602 105.212 107.365 1.00 52.83  ? 734 GLU B CB  1 
ATOM 8750 C CG  . GLU B 1 734 ? 125.865 105.477 106.560 1.00 57.77  ? 734 GLU B CG  1 
ATOM 8751 C CD  . GLU B 1 734 ? 126.955 104.456 106.821 1.00 63.59  ? 734 GLU B CD  1 
ATOM 8752 O OE1 . GLU B 1 734 ? 126.750 103.566 107.671 1.00 59.28  ? 734 GLU B OE1 1 
ATOM 8753 O OE2 . GLU B 1 734 ? 128.020 104.545 106.174 1.00 62.60  ? 734 GLU B OE2 1 
ATOM 8754 N N   . THR B 1 735 ? 121.455 105.673 108.338 1.00 52.71  ? 735 THR B N   1 
ATOM 8755 C CA  . THR B 1 735 ? 120.201 105.101 108.809 1.00 52.93  ? 735 THR B CA  1 
ATOM 8756 C C   . THR B 1 735 ? 119.002 105.589 108.011 1.00 46.25  ? 735 THR B C   1 
ATOM 8757 O O   . THR B 1 735 ? 117.895 105.080 108.214 1.00 45.42  ? 735 THR B O   1 
ATOM 8758 C CB  . THR B 1 735 ? 119.987 105.427 110.288 1.00 51.44  ? 735 THR B CB  1 
ATOM 8759 O OG1 . THR B 1 735 ? 119.421 106.735 110.413 1.00 48.18  ? 735 THR B OG1 1 
ATOM 8760 C CG2 . THR B 1 735 ? 121.306 105.395 111.026 1.00 51.95  ? 735 THR B CG2 1 
ATOM 8761 N N   . ARG B 1 736 ? 119.192 106.570 107.128 1.00 56.07  ? 736 ARG B N   1 
ATOM 8762 C CA  . ARG B 1 736 ? 118.091 107.070 106.315 1.00 54.03  ? 736 ARG B CA  1 
ATOM 8763 C C   . ARG B 1 736 ? 117.642 106.028 105.301 1.00 47.51  ? 736 ARG B C   1 
ATOM 8764 O O   . ARG B 1 736 ? 116.445 105.750 105.174 1.00 47.84  ? 736 ARG B O   1 
ATOM 8765 C CB  . ARG B 1 736 ? 118.508 108.360 105.609 1.00 60.11  ? 736 ARG B CB  1 
ATOM 8766 C CG  . ARG B 1 736 ? 117.361 109.288 105.242 1.00 55.30  ? 736 ARG B CG  1 
ATOM 8767 C CD  . ARG B 1 736 ? 116.889 110.092 106.441 1.00 52.62  ? 736 ARG B CD  1 
ATOM 8768 N NE  . ARG B 1 736 ? 117.987 110.796 107.094 1.00 52.73  ? 736 ARG B NE  1 
ATOM 8769 C CZ  . ARG B 1 736 ? 118.250 112.086 106.937 1.00 57.05  ? 736 ARG B CZ  1 
ATOM 8770 N NH1 . ARG B 1 736 ? 117.520 112.848 106.139 1.00 60.70  ? 736 ARG B NH1 1 
ATOM 8771 N NH2 . ARG B 1 736 ? 119.273 112.624 107.594 1.00 52.84  ? 736 ARG B NH2 1 
ATOM 8772 N N   . GLN B 1 737 ? 118.589 105.438 104.571 1.00 48.92  ? 737 GLN B N   1 
ATOM 8773 C CA  . GLN B 1 737 ? 118.243 104.436 103.570 1.00 55.85  ? 737 GLN B CA  1 
ATOM 8774 C C   . GLN B 1 737 ? 118.066 103.048 104.166 1.00 61.76  ? 737 GLN B C   1 
ATOM 8775 O O   . GLN B 1 737 ? 117.490 102.175 103.508 1.00 61.94  ? 737 GLN B O   1 
ATOM 8776 C CB  . GLN B 1 737 ? 119.310 104.390 102.469 1.00 54.57  ? 737 GLN B CB  1 
ATOM 8777 C CG  . GLN B 1 737 ? 120.646 103.764 102.873 1.00 49.72  ? 737 GLN B CG  1 
ATOM 8778 C CD  . GLN B 1 737 ? 121.563 104.707 103.641 1.00 54.35  ? 737 GLN B CD  1 
ATOM 8779 O OE1 . GLN B 1 737 ? 121.113 105.628 104.322 1.00 59.11  ? 737 GLN B OE1 1 
ATOM 8780 N NE2 . GLN B 1 737 ? 122.866 104.473 103.531 1.00 47.52  ? 737 GLN B NE2 1 
ATOM 8781 N N   . ALA B 1 738 ? 118.554 102.820 105.386 1.00 55.51  ? 738 ALA B N   1 
ATOM 8782 C CA  . ALA B 1 738 ? 118.333 101.538 106.043 1.00 55.05  ? 738 ALA B CA  1 
ATOM 8783 C C   . ALA B 1 738 ? 116.918 101.429 106.597 1.00 60.54  ? 738 ALA B C   1 
ATOM 8784 O O   . ALA B 1 738 ? 116.292 100.368 106.504 1.00 54.36  ? 738 ALA B O   1 
ATOM 8785 C CB  . ALA B 1 738 ? 119.361 101.336 107.153 1.00 49.06  ? 738 ALA B CB  1 
ATOM 8786 N N   . ALA B 1 739 ? 116.404 102.509 107.189 1.00 62.07  ? 739 ALA B N   1 
ATOM 8787 C CA  . ALA B 1 739 ? 115.014 102.524 107.625 1.00 50.79  ? 739 ALA B CA  1 
ATOM 8788 C C   . ALA B 1 739 ? 114.055 102.711 106.460 1.00 43.73  ? 739 ALA B C   1 
ATOM 8789 O O   . ALA B 1 739 ? 112.875 102.371 106.583 1.00 54.88  ? 739 ALA B O   1 
ATOM 8790 C CB  . ALA B 1 739 ? 114.798 103.622 108.664 1.00 52.51  ? 739 ALA B CB  1 
ATOM 8791 N N   . GLU B 1 740 ? 114.534 103.254 105.341 1.00 33.98  ? 740 GLU B N   1 
ATOM 8792 C CA  . GLU B 1 740 ? 113.754 103.270 104.112 1.00 41.26  ? 740 GLU B CA  1 
ATOM 8793 C C   . GLU B 1 740 ? 113.627 101.872 103.517 1.00 42.34  ? 740 GLU B C   1 
ATOM 8794 O O   . GLU B 1 740 ? 112.639 101.586 102.831 1.00 49.59  ? 740 GLU B O   1 
ATOM 8795 C CB  . GLU B 1 740 ? 114.397 104.261 103.131 1.00 53.33  ? 740 GLU B CB  1 
ATOM 8796 C CG  . GLU B 1 740 ? 114.168 104.039 101.642 1.00 49.81  ? 740 GLU B CG  1 
ATOM 8797 C CD  . GLU B 1 740 ? 115.154 104.810 100.786 1.00 55.99  ? 740 GLU B CD  1 
ATOM 8798 O OE1 . GLU B 1 740 ? 115.415 105.992 101.098 1.00 50.09  ? 740 GLU B OE1 1 
ATOM 8799 O OE2 . GLU B 1 740 ? 115.669 104.236 99.804  1.00 54.79  ? 740 GLU B OE2 1 
ATOM 8800 N N   . LEU B 1 741 ? 114.578 100.982 103.817 1.00 42.79  ? 741 LEU B N   1 
ATOM 8801 C CA  . LEU B 1 741 ? 114.523 99.613  103.311 1.00 55.04  ? 741 LEU B CA  1 
ATOM 8802 C C   . LEU B 1 741 ? 113.359 98.826  103.902 1.00 59.60  ? 741 LEU B C   1 
ATOM 8803 O O   . LEU B 1 741 ? 112.880 97.876  103.273 1.00 60.67  ? 741 LEU B O   1 
ATOM 8804 C CB  . LEU B 1 741 ? 115.842 98.896  103.597 1.00 52.51  ? 741 LEU B CB  1 
ATOM 8805 C CG  . LEU B 1 741 ? 116.283 97.788  102.636 1.00 52.56  ? 741 LEU B CG  1 
ATOM 8806 C CD1 . LEU B 1 741 ? 115.874 98.092  101.199 1.00 53.02  ? 741 LEU B CD1 1 
ATOM 8807 C CD2 . LEU B 1 741 ? 117.785 97.576  102.734 1.00 53.64  ? 741 LEU B CD2 1 
ATOM 8808 N N   . CYS B 1 742 ? 112.906 99.185  105.107 1.00 58.99  ? 742 CYS B N   1 
ATOM 8809 C CA  . CYS B 1 742 ? 111.714 98.555  105.667 1.00 47.23  ? 742 CYS B CA  1 
ATOM 8810 C C   . CYS B 1 742 ? 110.476 98.885  104.842 1.00 39.29  ? 742 CYS B C   1 
ATOM 8811 O O   . CYS B 1 742 ? 109.629 98.017  104.611 1.00 40.49  ? 742 CYS B O   1 
ATOM 8812 C CB  . CYS B 1 742 ? 111.520 98.989  107.119 1.00 39.00  ? 742 CYS B CB  1 
ATOM 8813 S SG  . CYS B 1 742 ? 112.861 98.507  108.219 1.00 66.41  ? 742 CYS B SG  1 
ATOM 8814 N N   . VAL B 1 743 ? 110.360 100.136 104.390 1.00 43.37  ? 743 VAL B N   1 
ATOM 8815 C CA  . VAL B 1 743 ? 109.233 100.539 103.555 1.00 38.42  ? 743 VAL B CA  1 
ATOM 8816 C C   . VAL B 1 743 ? 109.293 99.850  102.198 1.00 39.91  ? 743 VAL B C   1 
ATOM 8817 O O   . VAL B 1 743 ? 108.257 99.537  101.601 1.00 47.20  ? 743 VAL B O   1 
ATOM 8818 C CB  . VAL B 1 743 ? 109.206 102.071 103.405 1.00 36.46  ? 743 VAL B CB  1 
ATOM 8819 C CG1 . VAL B 1 743 ? 107.860 102.536 102.879 1.00 34.59  ? 743 VAL B CG1 1 
ATOM 8820 C CG2 . VAL B 1 743 ? 109.535 102.742 104.721 1.00 39.72  ? 743 VAL B CG2 1 
ATOM 8821 N N   . GLU B 1 744 ? 110.504 99.624  101.682 1.00 37.47  ? 744 GLU B N   1 
ATOM 8822 C CA  . GLU B 1 744 ? 110.659 99.057  100.344 1.00 44.96  ? 744 GLU B CA  1 
ATOM 8823 C C   . GLU B 1 744 ? 110.159 97.618  100.282 1.00 47.04  ? 744 GLU B C   1 
ATOM 8824 O O   . GLU B 1 744 ? 109.564 97.205  99.280  1.00 48.39  ? 744 GLU B O   1 
ATOM 8825 C CB  . GLU B 1 744 ? 112.125 99.145  99.911  1.00 45.73  ? 744 GLU B CB  1 
ATOM 8826 C CG  . GLU B 1 744 ? 112.460 98.617  98.505  1.00 44.55  ? 744 GLU B CG  1 
ATOM 8827 C CD  . GLU B 1 744 ? 111.382 98.865  97.457  1.00 44.40  ? 744 GLU B CD  1 
ATOM 8828 O OE1 . GLU B 1 744 ? 110.900 100.012 97.329  1.00 43.83  ? 744 GLU B OE1 1 
ATOM 8829 O OE2 . GLU B 1 744 ? 111.015 97.899  96.756  1.00 46.75  ? 744 GLU B OE2 1 
ATOM 8830 N N   . ARG B 1 745 ? 110.377 96.843  101.337 1.00 50.41  ? 745 ARG B N   1 
ATOM 8831 C CA  . ARG B 1 745 ? 109.914 95.464  101.361 1.00 53.13  ? 745 ARG B CA  1 
ATOM 8832 C C   . ARG B 1 745 ? 108.516 95.315  101.949 1.00 53.91  ? 745 ARG B C   1 
ATOM 8833 O O   . ARG B 1 745 ? 107.966 94.210  101.923 1.00 59.90  ? 745 ARG B O   1 
ATOM 8834 C CB  . ARG B 1 745 ? 110.902 94.587  102.137 1.00 44.28  ? 745 ARG B CB  1 
ATOM 8835 C CG  . ARG B 1 745 ? 112.358 94.929  101.872 1.00 44.86  ? 745 ARG B CG  1 
ATOM 8836 C CD  . ARG B 1 745 ? 113.285 93.852  102.398 1.00 47.66  ? 745 ARG B CD  1 
ATOM 8837 N NE  . ARG B 1 745 ? 112.881 92.528  101.944 1.00 50.74  ? 745 ARG B NE  1 
ATOM 8838 C CZ  . ARG B 1 745 ? 113.171 92.022  100.753 1.00 50.67  ? 745 ARG B CZ  1 
ATOM 8839 N NH1 . ARG B 1 745 ? 113.883 92.699  99.868  1.00 47.96  ? 745 ARG B NH1 1 
ATOM 8840 N NH2 . ARG B 1 745 ? 112.735 90.806  100.442 1.00 47.25  ? 745 ARG B NH2 1 
ATOM 8841 N N   . ILE B 1 746 ? 107.925 96.393  102.468 1.00 40.64  ? 746 ILE B N   1 
ATOM 8842 C CA  . ILE B 1 746 ? 106.574 96.314  103.012 1.00 30.50  ? 746 ILE B CA  1 
ATOM 8843 C C   . ILE B 1 746 ? 105.511 96.555  101.946 1.00 23.45  ? 746 ILE B C   1 
ATOM 8844 O O   . ILE B 1 746 ? 104.337 96.231  102.171 1.00 36.20  ? 746 ILE B O   1 
ATOM 8845 C CB  . ILE B 1 746 ? 106.408 97.297  104.188 1.00 30.16  ? 746 ILE B CB  1 
ATOM 8846 C CG1 . ILE B 1 746 ? 105.444 96.742  105.229 1.00 21.62  ? 746 ILE B CG1 1 
ATOM 8847 C CG2 . ILE B 1 746 ? 105.920 98.654  103.721 1.00 39.79  ? 746 ILE B CG2 1 
ATOM 8848 C CD1 . ILE B 1 746 ? 105.352 97.599  106.456 1.00 21.94  ? 746 ILE B CD1 1 
ATOM 8849 N N   . ARG B 1 747 ? 105.888 97.095  100.790 1.00 38.62  ? 747 ARG B N   1 
ATOM 8850 C CA  . ARG B 1 747 ? 104.964 97.297  99.685  1.00 44.60  ? 747 ARG B CA  1 
ATOM 8851 C C   . ARG B 1 747 ? 104.960 96.134  98.703  1.00 43.24  ? 747 ARG B C   1 
ATOM 8852 O O   . ARG B 1 747 ? 104.149 96.132  97.770  1.00 47.72  ? 747 ARG B O   1 
ATOM 8853 C CB  . ARG B 1 747 ? 105.297 98.601  98.951  1.00 43.91  ? 747 ARG B CB  1 
ATOM 8854 C CG  . ARG B 1 747 ? 106.488 98.512  98.014  1.00 44.15  ? 747 ARG B CG  1 
ATOM 8855 C CD  . ARG B 1 747 ? 106.521 99.703  97.080  1.00 46.83  ? 747 ARG B CD  1 
ATOM 8856 N NE  . ARG B 1 747 ? 106.431 100.957 97.818  1.00 45.22  ? 747 ARG B NE  1 
ATOM 8857 C CZ  . ARG B 1 747 ? 107.477 101.660 98.229  1.00 49.03  ? 747 ARG B CZ  1 
ATOM 8858 N NH1 . ARG B 1 747 ? 108.715 101.263 97.986  1.00 43.77  ? 747 ARG B NH1 1 
ATOM 8859 N NH2 . ARG B 1 747 ? 107.276 102.789 98.902  1.00 50.67  ? 747 ARG B NH2 1 
ATOM 8860 N N   . LEU B 1 748 ? 105.841 95.150  98.886  1.00 39.73  ? 748 LEU B N   1 
ATOM 8861 C CA  . LEU B 1 748 ? 105.792 93.928  98.094  1.00 42.58  ? 748 LEU B CA  1 
ATOM 8862 C C   . LEU B 1 748 ? 104.654 93.012  98.517  1.00 46.75  ? 748 LEU B C   1 
ATOM 8863 O O   . LEU B 1 748 ? 104.257 92.138  97.738  1.00 48.53  ? 748 LEU B O   1 
ATOM 8864 C CB  . LEU B 1 748 ? 107.123 93.177  98.197  1.00 43.13  ? 748 LEU B CB  1 
ATOM 8865 C CG  . LEU B 1 748 ? 108.149 93.393  97.080  1.00 46.17  ? 748 LEU B CG  1 
ATOM 8866 C CD1 . LEU B 1 748 ? 107.592 92.917  95.747  1.00 43.68  ? 748 LEU B CD1 1 
ATOM 8867 C CD2 . LEU B 1 748 ? 108.596 94.847  96.995  1.00 46.04  ? 748 LEU B CD2 1 
ATOM 8868 N N   . VAL B 1 749 ? 104.136 93.189  99.734  1.00 39.80  ? 749 VAL B N   1 
ATOM 8869 C CA  . VAL B 1 749 ? 102.953 92.469  100.190 1.00 38.92  ? 749 VAL B CA  1 
ATOM 8870 C C   . VAL B 1 749 ? 101.700 92.881  99.426  1.00 42.20  ? 749 VAL B C   1 
ATOM 8871 O O   . VAL B 1 749 ? 100.848 92.030  99.138  1.00 33.63  ? 749 VAL B O   1 
ATOM 8872 C CB  . VAL B 1 749 ? 102.768 92.705  101.699 1.00 35.40  ? 749 VAL B CB  1 
ATOM 8873 C CG1 . VAL B 1 749 ? 101.618 91.885  102.247 1.00 38.44  ? 749 VAL B CG1 1 
ATOM 8874 C CG2 . VAL B 1 749 ? 104.055 92.395  102.445 1.00 24.03  ? 749 VAL B CG2 1 
ATOM 8875 N N   . LEU B 1 750 ? 101.588 94.162  99.062  1.00 45.19  ? 750 LEU B N   1 
ATOM 8876 C CA  . LEU B 1 750 ? 100.348 94.719  98.534  1.00 43.19  ? 750 LEU B CA  1 
ATOM 8877 C C   . LEU B 1 750 ? 99.965  94.152  97.170  1.00 44.35  ? 750 LEU B C   1 
ATOM 8878 O O   . LEU B 1 750 ? 98.790  94.220  96.796  1.00 45.38  ? 750 LEU B O   1 
ATOM 8879 C CB  . LEU B 1 750 ? 100.459 96.243  98.451  1.00 38.47  ? 750 LEU B CB  1 
ATOM 8880 C CG  . LEU B 1 750 ? 100.057 97.108  99.657  1.00 41.78  ? 750 LEU B CG  1 
ATOM 8881 C CD1 . LEU B 1 750 ? 98.561  97.013  99.913  1.00 45.08  ? 750 LEU B CD1 1 
ATOM 8882 C CD2 . LEU B 1 750 ? 100.846 96.795  100.927 1.00 29.54  ? 750 LEU B CD2 1 
ATOM 8883 N N   . THR B 1 751 ? 100.913 93.600  96.425  1.00 53.85  ? 751 THR B N   1 
ATOM 8884 C CA  . THR B 1 751 ? 100.605 93.022  95.118  1.00 54.39  ? 751 THR B CA  1 
ATOM 8885 C C   . THR B 1 751 ? 99.866  91.699  95.283  1.00 53.16  ? 751 THR B C   1 
ATOM 8886 O O   . THR B 1 751 ? 100.134 90.968  96.245  1.00 56.89  ? 751 THR B O   1 
ATOM 8887 C CB  . THR B 1 751 ? 101.884 92.807  94.311  1.00 54.71  ? 751 THR B CB  1 
ATOM 8888 O OG1 . THR B 1 751 ? 102.829 92.063  95.092  1.00 57.62  ? 751 THR B OG1 1 
ATOM 8889 C CG2 . THR B 1 751 ? 102.497 94.142  93.906  1.00 58.55  ? 751 THR B CG2 1 
ATOM 8890 N N   . PRO B 1 752 ? 98.929  91.351  94.385  1.00 63.12  ? 752 PRO B N   1 
ATOM 8891 C CA  . PRO B 1 752 ? 98.266  90.042  94.413  1.00 63.75  ? 752 PRO B CA  1 
ATOM 8892 C C   . PRO B 1 752 ? 99.194  88.907  93.996  1.00 68.75  ? 752 PRO B C   1 
ATOM 8893 O O   . PRO B 1 752 ? 99.211  88.556  92.816  1.00 70.19  ? 752 PRO B O   1 
ATOM 8894 C CB  . PRO B 1 752 ? 97.120  90.203  93.406  1.00 65.72  ? 752 PRO B CB  1 
ATOM 8895 C CG  . PRO B 1 752 ? 96.939  91.679  93.252  1.00 64.70  ? 752 PRO B CG  1 
ATOM 8896 C CD  . PRO B 1 752 ? 98.308  92.256  93.405  1.00 62.16  ? 752 PRO B CD  1 
# 
