data_8ZVP
# 
_entry.id   8ZVP 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZVP         pdb_00008zvp 10.2210/pdb8zvp/pdb 
WWPDB D_1300048424 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZVP 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-11 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wy83@ustc.edu.cn 
_pdbx_contact_author.name_first         Yi 
_pdbx_contact_author.name_last          WANG 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0797-5209 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Song, B.' 1 ? 
'Wang, Y.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'SIRT6 in complex with EGCG' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Song, B.' 1 ? 
primary 'Wang, Y.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NAD-dependent protein deacylase sirtuin-6' 33346.301 2 2.3.1.-,2.3.1.286,2.4.2.- ? ? ? 
2 non-polymer syn 'ZINC ION' 65.409    2 ?                         ? ? ? 
3 non-polymer syn 
;[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
;
559.316   2 ?                         ? ? ? 
4 non-polymer syn '(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate' 458.372 
1 ?                         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;NAD-dependent protein deacetylase sirtuin-6,Protein mono-ADP-ribosyltransferase sirtuin-6,Regulatory protein SIR2 homolog 6,hSIRT6,SIR2-like protein 6
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESA
RPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVA
KARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRH
ADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRIN
;
_entity_poly.pdbx_seq_one_letter_code_can   
;PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESA
RPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVA
KARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRH
ADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRIN
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION' ZN  
3 
;[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
;
AR6 
4 '(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate' KDH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   PRO n 
1 2   PHE n 
1 3   THR n 
1 4   ALA n 
1 5   ASP n 
1 6   LYS n 
1 7   GLY n 
1 8   LYS n 
1 9   CYS n 
1 10  GLY n 
1 11  LEU n 
1 12  PRO n 
1 13  GLU n 
1 14  ILE n 
1 15  PHE n 
1 16  ASP n 
1 17  PRO n 
1 18  PRO n 
1 19  GLU n 
1 20  GLU n 
1 21  LEU n 
1 22  GLU n 
1 23  ARG n 
1 24  LYS n 
1 25  VAL n 
1 26  TRP n 
1 27  GLU n 
1 28  LEU n 
1 29  ALA n 
1 30  ARG n 
1 31  LEU n 
1 32  VAL n 
1 33  TRP n 
1 34  GLN n 
1 35  SER n 
1 36  SER n 
1 37  SER n 
1 38  VAL n 
1 39  VAL n 
1 40  PHE n 
1 41  HIS n 
1 42  THR n 
1 43  GLY n 
1 44  ALA n 
1 45  GLY n 
1 46  ILE n 
1 47  SER n 
1 48  THR n 
1 49  ALA n 
1 50  SER n 
1 51  GLY n 
1 52  ILE n 
1 53  PRO n 
1 54  ASP n 
1 55  PHE n 
1 56  ARG n 
1 57  GLY n 
1 58  PRO n 
1 59  HIS n 
1 60  GLY n 
1 61  VAL n 
1 62  TRP n 
1 63  THR n 
1 64  MET n 
1 65  GLU n 
1 66  GLU n 
1 67  ARG n 
1 68  GLY n 
1 69  LEU n 
1 70  ALA n 
1 71  PRO n 
1 72  LYS n 
1 73  PHE n 
1 74  ASP n 
1 75  THR n 
1 76  THR n 
1 77  PHE n 
1 78  GLU n 
1 79  SER n 
1 80  ALA n 
1 81  ARG n 
1 82  PRO n 
1 83  THR n 
1 84  GLN n 
1 85  THR n 
1 86  HIS n 
1 87  MET n 
1 88  ALA n 
1 89  LEU n 
1 90  VAL n 
1 91  GLN n 
1 92  LEU n 
1 93  GLU n 
1 94  ARG n 
1 95  VAL n 
1 96  GLY n 
1 97  LEU n 
1 98  LEU n 
1 99  ARG n 
1 100 PHE n 
1 101 LEU n 
1 102 VAL n 
1 103 SER n 
1 104 GLN n 
1 105 ASN n 
1 106 VAL n 
1 107 ASP n 
1 108 GLY n 
1 109 LEU n 
1 110 HIS n 
1 111 VAL n 
1 112 ARG n 
1 113 SER n 
1 114 GLY n 
1 115 PHE n 
1 116 PRO n 
1 117 ARG n 
1 118 ASP n 
1 119 LYS n 
1 120 LEU n 
1 121 ALA n 
1 122 GLU n 
1 123 LEU n 
1 124 HIS n 
1 125 GLY n 
1 126 ASN n 
1 127 MET n 
1 128 PHE n 
1 129 VAL n 
1 130 GLU n 
1 131 GLU n 
1 132 CYS n 
1 133 ALA n 
1 134 LYS n 
1 135 CYS n 
1 136 LYS n 
1 137 THR n 
1 138 GLN n 
1 139 TYR n 
1 140 VAL n 
1 141 ARG n 
1 142 ASP n 
1 143 THR n 
1 144 VAL n 
1 145 VAL n 
1 146 GLY n 
1 147 THR n 
1 148 MET n 
1 149 GLY n 
1 150 LEU n 
1 151 LYS n 
1 152 ALA n 
1 153 THR n 
1 154 GLY n 
1 155 ARG n 
1 156 LEU n 
1 157 CYS n 
1 158 THR n 
1 159 VAL n 
1 160 ALA n 
1 161 LYS n 
1 162 ALA n 
1 163 ARG n 
1 164 GLY n 
1 165 LEU n 
1 166 ARG n 
1 167 ALA n 
1 168 CYS n 
1 169 ARG n 
1 170 GLY n 
1 171 GLU n 
1 172 LEU n 
1 173 ARG n 
1 174 ASP n 
1 175 THR n 
1 176 ILE n 
1 177 LEU n 
1 178 ASP n 
1 179 TRP n 
1 180 GLU n 
1 181 ASP n 
1 182 SER n 
1 183 LEU n 
1 184 PRO n 
1 185 ASP n 
1 186 ARG n 
1 187 ASP n 
1 188 LEU n 
1 189 ALA n 
1 190 LEU n 
1 191 ALA n 
1 192 ASP n 
1 193 GLU n 
1 194 ALA n 
1 195 SER n 
1 196 ARG n 
1 197 ASN n 
1 198 ALA n 
1 199 ASP n 
1 200 LEU n 
1 201 SER n 
1 202 ILE n 
1 203 THR n 
1 204 LEU n 
1 205 GLY n 
1 206 THR n 
1 207 SER n 
1 208 LEU n 
1 209 GLN n 
1 210 ILE n 
1 211 ARG n 
1 212 PRO n 
1 213 SER n 
1 214 GLY n 
1 215 ASN n 
1 216 LEU n 
1 217 PRO n 
1 218 LEU n 
1 219 ALA n 
1 220 THR n 
1 221 LYS n 
1 222 ARG n 
1 223 ARG n 
1 224 GLY n 
1 225 GLY n 
1 226 ARG n 
1 227 LEU n 
1 228 VAL n 
1 229 ILE n 
1 230 VAL n 
1 231 ASN n 
1 232 LEU n 
1 233 GLN n 
1 234 PRO n 
1 235 THR n 
1 236 LYS n 
1 237 HIS n 
1 238 ASP n 
1 239 ARG n 
1 240 HIS n 
1 241 ALA n 
1 242 ASP n 
1 243 LEU n 
1 244 ARG n 
1 245 ILE n 
1 246 HIS n 
1 247 GLY n 
1 248 TYR n 
1 249 VAL n 
1 250 ASP n 
1 251 GLU n 
1 252 VAL n 
1 253 MET n 
1 254 THR n 
1 255 ARG n 
1 256 LEU n 
1 257 MET n 
1 258 LYS n 
1 259 HIS n 
1 260 LEU n 
1 261 GLY n 
1 262 LEU n 
1 263 GLU n 
1 264 ILE n 
1 265 PRO n 
1 266 ALA n 
1 267 TRP n 
1 268 ASP n 
1 269 GLY n 
1 270 PRO n 
1 271 ARG n 
1 272 VAL n 
1 273 LEU n 
1 274 GLU n 
1 275 ARG n 
1 276 ALA n 
1 277 LEU n 
1 278 PRO n 
1 279 PRO n 
1 280 LEU n 
1 281 PRO n 
1 282 ARG n 
1 283 PRO n 
1 284 PRO n 
1 285 THR n 
1 286 PRO n 
1 287 LYS n 
1 288 LEU n 
1 289 GLU n 
1 290 PRO n 
1 291 LYS n 
1 292 GLU n 
1 293 GLU n 
1 294 SER n 
1 295 PRO n 
1 296 THR n 
1 297 ARG n 
1 298 ILE n 
1 299 ASN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   299 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SIRT6, SIR2L6' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ?                                      'C3 H7 N O2'        89.093  
AR6 non-polymer         . 
;[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
;
Adenosine-5-Diphosphoribose            'C15 H23 N5 O14 P2' 559.316 
ARG 'L-peptide linking' y ARGININE ?                                      'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE ?                                      'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                                      'C4 H7 N O4'        133.103 
CYS 'L-peptide linking' y CYSTEINE ?                                      'C3 H7 N O2 S'      121.158 
GLN 'L-peptide linking' y GLUTAMINE ?                                      'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                                      'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE ?                                      'C2 H5 N O2'        75.067  
HIS 'L-peptide linking' y HISTIDINE ?                                      'C6 H10 N3 O2 1'    156.162 
ILE 'L-peptide linking' y ISOLEUCINE ?                                      'C6 H13 N O2'       131.173 
KDH non-polymer         . '(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate' 
'(-)-Epigallocatechin-3-gallate; EGCG' 'C22 H18 O11'       458.372 
LEU 'L-peptide linking' y LEUCINE ?                                      'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE ?                                      'C6 H15 N2 O2 1'    147.195 
MET 'L-peptide linking' y METHIONINE ?                                      'C5 H11 N O2 S'     149.211 
PHE 'L-peptide linking' y PHENYLALANINE ?                                      'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE ?                                      'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE ?                                      'C3 H7 N O3'        105.093 
THR 'L-peptide linking' y THREONINE ?                                      'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ?                                      'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE ?                                      'C9 H11 N O3'       181.189 
VAL 'L-peptide linking' y VALINE ?                                      'C5 H11 N O2'       117.146 
ZN  non-polymer         . 'ZINC ION' ?                                      'Zn 2'              65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   PRO 1   10  10  PRO PRO A . n 
A 1 2   PHE 2   11  11  PHE PHE A . n 
A 1 3   THR 3   12  12  THR THR A . n 
A 1 4   ALA 4   13  13  ALA ALA A . n 
A 1 5   ASP 5   14  14  ASP ASP A . n 
A 1 6   LYS 6   15  15  LYS LYS A . n 
A 1 7   GLY 7   16  16  GLY GLY A . n 
A 1 8   LYS 8   17  17  LYS LYS A . n 
A 1 9   CYS 9   18  18  CYS CYS A . n 
A 1 10  GLY 10  19  19  GLY GLY A . n 
A 1 11  LEU 11  20  20  LEU LEU A . n 
A 1 12  PRO 12  21  21  PRO PRO A . n 
A 1 13  GLU 13  22  22  GLU GLU A . n 
A 1 14  ILE 14  23  23  ILE ILE A . n 
A 1 15  PHE 15  24  24  PHE PHE A . n 
A 1 16  ASP 16  25  25  ASP ASP A . n 
A 1 17  PRO 17  26  26  PRO PRO A . n 
A 1 18  PRO 18  27  27  PRO PRO A . n 
A 1 19  GLU 19  28  28  GLU GLU A . n 
A 1 20  GLU 20  29  29  GLU GLU A . n 
A 1 21  LEU 21  30  30  LEU LEU A . n 
A 1 22  GLU 22  31  31  GLU GLU A . n 
A 1 23  ARG 23  32  32  ARG ARG A . n 
A 1 24  LYS 24  33  33  LYS LYS A . n 
A 1 25  VAL 25  34  34  VAL VAL A . n 
A 1 26  TRP 26  35  35  TRP TRP A . n 
A 1 27  GLU 27  36  36  GLU GLU A . n 
A 1 28  LEU 28  37  37  LEU LEU A . n 
A 1 29  ALA 29  38  38  ALA ALA A . n 
A 1 30  ARG 30  39  39  ARG ARG A . n 
A 1 31  LEU 31  40  40  LEU LEU A . n 
A 1 32  VAL 32  41  41  VAL VAL A . n 
A 1 33  TRP 33  42  42  TRP TRP A . n 
A 1 34  GLN 34  43  43  GLN GLN A . n 
A 1 35  SER 35  44  44  SER SER A . n 
A 1 36  SER 36  45  45  SER SER A . n 
A 1 37  SER 37  46  46  SER SER A . n 
A 1 38  VAL 38  47  47  VAL VAL A . n 
A 1 39  VAL 39  48  48  VAL VAL A . n 
A 1 40  PHE 40  49  49  PHE PHE A . n 
A 1 41  HIS 41  50  50  HIS HIS A . n 
A 1 42  THR 42  51  51  THR THR A . n 
A 1 43  GLY 43  52  52  GLY GLY A . n 
A 1 44  ALA 44  53  53  ALA ALA A . n 
A 1 45  GLY 45  54  54  GLY GLY A . n 
A 1 46  ILE 46  55  55  ILE ILE A . n 
A 1 47  SER 47  56  56  SER SER A . n 
A 1 48  THR 48  57  57  THR THR A . n 
A 1 49  ALA 49  58  58  ALA ALA A . n 
A 1 50  SER 50  59  59  SER SER A . n 
A 1 51  GLY 51  60  60  GLY GLY A . n 
A 1 52  ILE 52  61  61  ILE ILE A . n 
A 1 53  PRO 53  62  62  PRO PRO A . n 
A 1 54  ASP 54  63  63  ASP ASP A . n 
A 1 55  PHE 55  64  64  PHE PHE A . n 
A 1 56  ARG 56  65  65  ARG ARG A . n 
A 1 57  GLY 57  66  66  GLY GLY A . n 
A 1 58  PRO 58  67  67  PRO PRO A . n 
A 1 59  HIS 59  68  68  HIS HIS A . n 
A 1 60  GLY 60  69  69  GLY GLY A . n 
A 1 61  VAL 61  70  70  VAL VAL A . n 
A 1 62  TRP 62  71  71  TRP TRP A . n 
A 1 63  THR 63  72  72  THR THR A . n 
A 1 64  MET 64  73  73  MET MET A . n 
A 1 65  GLU 65  74  74  GLU GLU A . n 
A 1 66  GLU 66  75  75  GLU GLU A . n 
A 1 67  ARG 67  76  76  ARG ARG A . n 
A 1 68  GLY 68  77  77  GLY GLY A . n 
A 1 69  LEU 69  78  78  LEU LEU A . n 
A 1 70  ALA 70  79  79  ALA ALA A . n 
A 1 71  PRO 71  80  80  PRO PRO A . n 
A 1 72  LYS 72  81  81  LYS LYS A . n 
A 1 73  PHE 73  82  82  PHE PHE A . n 
A 1 74  ASP 74  83  83  ASP ASP A . n 
A 1 75  THR 75  84  84  THR THR A . n 
A 1 76  THR 76  85  85  THR THR A . n 
A 1 77  PHE 77  86  86  PHE PHE A . n 
A 1 78  GLU 78  87  87  GLU GLU A . n 
A 1 79  SER 79  88  88  SER SER A . n 
A 1 80  ALA 80  89  89  ALA ALA A . n 
A 1 81  ARG 81  90  90  ARG ARG A . n 
A 1 82  PRO 82  91  91  PRO PRO A . n 
A 1 83  THR 83  92  92  THR THR A . n 
A 1 84  GLN 84  93  93  GLN GLN A . n 
A 1 85  THR 85  94  94  THR THR A . n 
A 1 86  HIS 86  95  95  HIS HIS A . n 
A 1 87  MET 87  96  96  MET MET A . n 
A 1 88  ALA 88  97  97  ALA ALA A . n 
A 1 89  LEU 89  98  98  LEU LEU A . n 
A 1 90  VAL 90  99  99  VAL VAL A . n 
A 1 91  GLN 91  100 100 GLN GLN A . n 
A 1 92  LEU 92  101 101 LEU LEU A . n 
A 1 93  GLU 93  102 102 GLU GLU A . n 
A 1 94  ARG 94  103 103 ARG ARG A . n 
A 1 95  VAL 95  104 104 VAL VAL A . n 
A 1 96  GLY 96  105 105 GLY GLY A . n 
A 1 97  LEU 97  106 106 LEU LEU A . n 
A 1 98  LEU 98  107 107 LEU LEU A . n 
A 1 99  ARG 99  108 108 ARG ARG A . n 
A 1 100 PHE 100 109 109 PHE PHE A . n 
A 1 101 LEU 101 110 110 LEU LEU A . n 
A 1 102 VAL 102 111 111 VAL VAL A . n 
A 1 103 SER 103 112 112 SER SER A . n 
A 1 104 GLN 104 113 113 GLN GLN A . n 
A 1 105 ASN 105 114 114 ASN ASN A . n 
A 1 106 VAL 106 115 115 VAL VAL A . n 
A 1 107 ASP 107 116 116 ASP ASP A . n 
A 1 108 GLY 108 117 117 GLY GLY A . n 
A 1 109 LEU 109 118 118 LEU LEU A . n 
A 1 110 HIS 110 119 119 HIS HIS A . n 
A 1 111 VAL 111 120 120 VAL VAL A . n 
A 1 112 ARG 112 121 121 ARG ARG A . n 
A 1 113 SER 113 122 122 SER SER A . n 
A 1 114 GLY 114 123 123 GLY GLY A . n 
A 1 115 PHE 115 124 124 PHE PHE A . n 
A 1 116 PRO 116 125 125 PRO PRO A . n 
A 1 117 ARG 117 126 126 ARG ARG A . n 
A 1 118 ASP 118 127 127 ASP ASP A . n 
A 1 119 LYS 119 128 128 LYS LYS A . n 
A 1 120 LEU 120 129 129 LEU LEU A . n 
A 1 121 ALA 121 130 130 ALA ALA A . n 
A 1 122 GLU 122 131 131 GLU GLU A . n 
A 1 123 LEU 123 132 132 LEU LEU A . n 
A 1 124 HIS 124 133 133 HIS HIS A . n 
A 1 125 GLY 125 134 134 GLY GLY A . n 
A 1 126 ASN 126 135 135 ASN ASN A . n 
A 1 127 MET 127 136 136 MET MET A . n 
A 1 128 PHE 128 137 137 PHE PHE A . n 
A 1 129 VAL 129 138 138 VAL VAL A . n 
A 1 130 GLU 130 139 139 GLU GLU A . n 
A 1 131 GLU 131 140 140 GLU GLU A . n 
A 1 132 CYS 132 141 141 CYS CYS A . n 
A 1 133 ALA 133 142 142 ALA ALA A . n 
A 1 134 LYS 134 143 143 LYS LYS A . n 
A 1 135 CYS 135 144 144 CYS CYS A . n 
A 1 136 LYS 136 145 145 LYS LYS A . n 
A 1 137 THR 137 146 146 THR THR A . n 
A 1 138 GLN 138 147 147 GLN GLN A . n 
A 1 139 TYR 139 148 148 TYR TYR A . n 
A 1 140 VAL 140 149 149 VAL VAL A . n 
A 1 141 ARG 141 150 150 ARG ARG A . n 
A 1 142 ASP 142 151 151 ASP ASP A . n 
A 1 143 THR 143 152 152 THR THR A . n 
A 1 144 VAL 144 153 153 VAL VAL A . n 
A 1 145 VAL 145 154 154 VAL VAL A . n 
A 1 146 GLY 146 155 155 GLY GLY A . n 
A 1 147 THR 147 156 156 THR THR A . n 
A 1 148 MET 148 157 157 MET MET A . n 
A 1 149 GLY 149 158 158 GLY GLY A . n 
A 1 150 LEU 150 159 159 LEU LEU A . n 
A 1 151 LYS 151 160 160 LYS LYS A . n 
A 1 152 ALA 152 161 161 ALA ALA A . n 
A 1 153 THR 153 162 162 THR THR A . n 
A 1 154 GLY 154 163 163 GLY GLY A . n 
A 1 155 ARG 155 164 164 ARG ARG A . n 
A 1 156 LEU 156 165 165 LEU LEU A . n 
A 1 157 CYS 157 166 166 CYS CYS A . n 
A 1 158 THR 158 167 167 THR THR A . n 
A 1 159 VAL 159 168 168 VAL VAL A . n 
A 1 160 ALA 160 169 169 ALA ALA A . n 
A 1 161 LYS 161 170 ?   ?   ?   A . n 
A 1 162 ALA 162 171 ?   ?   ?   A . n 
A 1 163 ARG 163 172 ?   ?   ?   A . n 
A 1 164 GLY 164 173 ?   ?   ?   A . n 
A 1 165 LEU 165 174 ?   ?   ?   A . n 
A 1 166 ARG 166 175 ?   ?   ?   A . n 
A 1 167 ALA 167 176 ?   ?   ?   A . n 
A 1 168 CYS 168 177 177 CYS CYS A . n 
A 1 169 ARG 169 178 178 ARG ARG A . n 
A 1 170 GLY 170 179 179 GLY GLY A . n 
A 1 171 GLU 171 180 180 GLU GLU A . n 
A 1 172 LEU 172 181 181 LEU LEU A . n 
A 1 173 ARG 173 182 182 ARG ARG A . n 
A 1 174 ASP 174 183 183 ASP ASP A . n 
A 1 175 THR 175 184 184 THR THR A . n 
A 1 176 ILE 176 185 185 ILE ILE A . n 
A 1 177 LEU 177 186 186 LEU LEU A . n 
A 1 178 ASP 178 187 187 ASP ASP A . n 
A 1 179 TRP 179 188 188 TRP TRP A . n 
A 1 180 GLU 180 189 189 GLU GLU A . n 
A 1 181 ASP 181 190 190 ASP ASP A . n 
A 1 182 SER 182 191 191 SER SER A . n 
A 1 183 LEU 183 192 192 LEU LEU A . n 
A 1 184 PRO 184 193 193 PRO PRO A . n 
A 1 185 ASP 185 194 194 ASP ASP A . n 
A 1 186 ARG 186 195 195 ARG ARG A . n 
A 1 187 ASP 187 196 196 ASP ASP A . n 
A 1 188 LEU 188 197 197 LEU LEU A . n 
A 1 189 ALA 189 198 198 ALA ALA A . n 
A 1 190 LEU 190 199 199 LEU LEU A . n 
A 1 191 ALA 191 200 200 ALA ALA A . n 
A 1 192 ASP 192 201 201 ASP ASP A . n 
A 1 193 GLU 193 202 202 GLU GLU A . n 
A 1 194 ALA 194 203 203 ALA ALA A . n 
A 1 195 SER 195 204 204 SER SER A . n 
A 1 196 ARG 196 205 205 ARG ARG A . n 
A 1 197 ASN 197 206 206 ASN ASN A . n 
A 1 198 ALA 198 207 207 ALA ALA A . n 
A 1 199 ASP 199 208 208 ASP ASP A . n 
A 1 200 LEU 200 209 209 LEU LEU A . n 
A 1 201 SER 201 210 210 SER SER A . n 
A 1 202 ILE 202 211 211 ILE ILE A . n 
A 1 203 THR 203 212 212 THR THR A . n 
A 1 204 LEU 204 213 213 LEU LEU A . n 
A 1 205 GLY 205 214 214 GLY GLY A . n 
A 1 206 THR 206 215 215 THR THR A . n 
A 1 207 SER 207 216 216 SER SER A . n 
A 1 208 LEU 208 217 217 LEU LEU A . n 
A 1 209 GLN 209 218 218 GLN GLN A . n 
A 1 210 ILE 210 219 219 ILE ILE A . n 
A 1 211 ARG 211 220 220 ARG ARG A . n 
A 1 212 PRO 212 221 221 PRO PRO A . n 
A 1 213 SER 213 222 222 SER SER A . n 
A 1 214 GLY 214 223 223 GLY GLY A . n 
A 1 215 ASN 215 224 224 ASN ASN A . n 
A 1 216 LEU 216 225 225 LEU LEU A . n 
A 1 217 PRO 217 226 226 PRO PRO A . n 
A 1 218 LEU 218 227 227 LEU LEU A . n 
A 1 219 ALA 219 228 228 ALA ALA A . n 
A 1 220 THR 220 229 229 THR THR A . n 
A 1 221 LYS 221 230 230 LYS LYS A . n 
A 1 222 ARG 222 231 231 ARG ARG A . n 
A 1 223 ARG 223 232 232 ARG ARG A . n 
A 1 224 GLY 224 233 233 GLY GLY A . n 
A 1 225 GLY 225 234 234 GLY GLY A . n 
A 1 226 ARG 226 235 235 ARG ARG A . n 
A 1 227 LEU 227 236 236 LEU LEU A . n 
A 1 228 VAL 228 237 237 VAL VAL A . n 
A 1 229 ILE 229 238 238 ILE ILE A . n 
A 1 230 VAL 230 239 239 VAL VAL A . n 
A 1 231 ASN 231 240 240 ASN ASN A . n 
A 1 232 LEU 232 241 241 LEU LEU A . n 
A 1 233 GLN 233 242 242 GLN GLN A . n 
A 1 234 PRO 234 243 243 PRO PRO A . n 
A 1 235 THR 235 244 244 THR THR A . n 
A 1 236 LYS 236 245 245 LYS LYS A . n 
A 1 237 HIS 237 246 246 HIS HIS A . n 
A 1 238 ASP 238 247 247 ASP ASP A . n 
A 1 239 ARG 239 248 248 ARG ARG A . n 
A 1 240 HIS 240 249 249 HIS HIS A . n 
A 1 241 ALA 241 250 250 ALA ALA A . n 
A 1 242 ASP 242 251 251 ASP ASP A . n 
A 1 243 LEU 243 252 252 LEU LEU A . n 
A 1 244 ARG 244 253 253 ARG ARG A . n 
A 1 245 ILE 245 254 254 ILE ILE A . n 
A 1 246 HIS 246 255 255 HIS HIS A . n 
A 1 247 GLY 247 256 256 GLY GLY A . n 
A 1 248 TYR 248 257 257 TYR TYR A . n 
A 1 249 VAL 249 258 258 VAL VAL A . n 
A 1 250 ASP 250 259 259 ASP ASP A . n 
A 1 251 GLU 251 260 260 GLU GLU A . n 
A 1 252 VAL 252 261 261 VAL VAL A . n 
A 1 253 MET 253 262 262 MET MET A . n 
A 1 254 THR 254 263 263 THR THR A . n 
A 1 255 ARG 255 264 264 ARG ARG A . n 
A 1 256 LEU 256 265 265 LEU LEU A . n 
A 1 257 MET 257 266 266 MET MET A . n 
A 1 258 LYS 258 267 267 LYS LYS A . n 
A 1 259 HIS 259 268 268 HIS HIS A . n 
A 1 260 LEU 260 269 269 LEU LEU A . n 
A 1 261 GLY 261 270 270 GLY GLY A . n 
A 1 262 LEU 262 271 271 LEU LEU A . n 
A 1 263 GLU 263 272 272 GLU GLU A . n 
A 1 264 ILE 264 273 273 ILE ILE A . n 
A 1 265 PRO 265 274 274 PRO PRO A . n 
A 1 266 ALA 266 275 275 ALA ALA A . n 
A 1 267 TRP 267 276 276 TRP TRP A . n 
A 1 268 ASP 268 277 277 ASP ASP A . n 
A 1 269 GLY 269 278 278 GLY GLY A . n 
A 1 270 PRO 270 279 279 PRO PRO A . n 
A 1 271 ARG 271 280 280 ARG ARG A . n 
A 1 272 VAL 272 281 281 VAL VAL A . n 
A 1 273 LEU 273 282 282 LEU LEU A . n 
A 1 274 GLU 274 283 283 GLU GLU A . n 
A 1 275 ARG 275 284 284 ARG ARG A . n 
A 1 276 ALA 276 285 285 ALA ALA A . n 
A 1 277 LEU 277 286 286 LEU LEU A . n 
A 1 278 PRO 278 287 287 PRO PRO A . n 
A 1 279 PRO 279 288 288 PRO PRO A . n 
A 1 280 LEU 280 289 289 LEU LEU A . n 
A 1 281 PRO 281 290 290 PRO PRO A . n 
A 1 282 ARG 282 291 291 ARG ARG A . n 
A 1 283 PRO 283 292 292 PRO PRO A . n 
A 1 284 PRO 284 293 293 PRO PRO A . n 
A 1 285 THR 285 294 294 THR THR A . n 
A 1 286 PRO 286 295 295 PRO PRO A . n 
A 1 287 LYS 287 296 296 LYS LYS A . n 
A 1 288 LEU 288 297 297 LEU LEU A . n 
A 1 289 GLU 289 298 298 GLU GLU A . n 
A 1 290 PRO 290 299 ?   ?   ?   A . n 
A 1 291 LYS 291 300 ?   ?   ?   A . n 
A 1 292 GLU 292 301 ?   ?   ?   A . n 
A 1 293 GLU 293 302 ?   ?   ?   A . n 
A 1 294 SER 294 303 ?   ?   ?   A . n 
A 1 295 PRO 295 304 ?   ?   ?   A . n 
A 1 296 THR 296 305 ?   ?   ?   A . n 
A 1 297 ARG 297 306 ?   ?   ?   A . n 
A 1 298 ILE 298 307 ?   ?   ?   A . n 
A 1 299 ASN 299 308 ?   ?   ?   A . n 
B 1 1   PRO 1   10  ?   ?   ?   B . n 
B 1 2   PHE 2   11  ?   ?   ?   B . n 
B 1 3   THR 3   12  ?   ?   ?   B . n 
B 1 4   ALA 4   13  13  ALA ALA B . n 
B 1 5   ASP 5   14  14  ASP ASP B . n 
B 1 6   LYS 6   15  15  LYS LYS B . n 
B 1 7   GLY 7   16  16  GLY GLY B . n 
B 1 8   LYS 8   17  17  LYS LYS B . n 
B 1 9   CYS 9   18  18  CYS CYS B . n 
B 1 10  GLY 10  19  19  GLY GLY B . n 
B 1 11  LEU 11  20  20  LEU LEU B . n 
B 1 12  PRO 12  21  21  PRO PRO B . n 
B 1 13  GLU 13  22  22  GLU GLU B . n 
B 1 14  ILE 14  23  23  ILE ILE B . n 
B 1 15  PHE 15  24  24  PHE PHE B . n 
B 1 16  ASP 16  25  25  ASP ASP B . n 
B 1 17  PRO 17  26  26  PRO PRO B . n 
B 1 18  PRO 18  27  27  PRO PRO B . n 
B 1 19  GLU 19  28  28  GLU GLU B . n 
B 1 20  GLU 20  29  29  GLU GLU B . n 
B 1 21  LEU 21  30  30  LEU LEU B . n 
B 1 22  GLU 22  31  31  GLU GLU B . n 
B 1 23  ARG 23  32  32  ARG ARG B . n 
B 1 24  LYS 24  33  33  LYS LYS B . n 
B 1 25  VAL 25  34  34  VAL VAL B . n 
B 1 26  TRP 26  35  35  TRP TRP B . n 
B 1 27  GLU 27  36  36  GLU GLU B . n 
B 1 28  LEU 28  37  37  LEU LEU B . n 
B 1 29  ALA 29  38  38  ALA ALA B . n 
B 1 30  ARG 30  39  39  ARG ARG B . n 
B 1 31  LEU 31  40  40  LEU LEU B . n 
B 1 32  VAL 32  41  41  VAL VAL B . n 
B 1 33  TRP 33  42  42  TRP TRP B . n 
B 1 34  GLN 34  43  43  GLN GLN B . n 
B 1 35  SER 35  44  44  SER SER B . n 
B 1 36  SER 36  45  45  SER SER B . n 
B 1 37  SER 37  46  46  SER SER B . n 
B 1 38  VAL 38  47  47  VAL VAL B . n 
B 1 39  VAL 39  48  48  VAL VAL B . n 
B 1 40  PHE 40  49  49  PHE PHE B . n 
B 1 41  HIS 41  50  50  HIS HIS B . n 
B 1 42  THR 42  51  51  THR THR B . n 
B 1 43  GLY 43  52  52  GLY GLY B . n 
B 1 44  ALA 44  53  53  ALA ALA B . n 
B 1 45  GLY 45  54  54  GLY GLY B . n 
B 1 46  ILE 46  55  55  ILE ILE B . n 
B 1 47  SER 47  56  56  SER SER B . n 
B 1 48  THR 48  57  57  THR THR B . n 
B 1 49  ALA 49  58  58  ALA ALA B . n 
B 1 50  SER 50  59  59  SER SER B . n 
B 1 51  GLY 51  60  60  GLY GLY B . n 
B 1 52  ILE 52  61  61  ILE ILE B . n 
B 1 53  PRO 53  62  62  PRO PRO B . n 
B 1 54  ASP 54  63  63  ASP ASP B . n 
B 1 55  PHE 55  64  64  PHE PHE B . n 
B 1 56  ARG 56  65  65  ARG ARG B . n 
B 1 57  GLY 57  66  66  GLY GLY B . n 
B 1 58  PRO 58  67  67  PRO PRO B . n 
B 1 59  HIS 59  68  68  HIS HIS B . n 
B 1 60  GLY 60  69  69  GLY GLY B . n 
B 1 61  VAL 61  70  70  VAL VAL B . n 
B 1 62  TRP 62  71  71  TRP TRP B . n 
B 1 63  THR 63  72  72  THR THR B . n 
B 1 64  MET 64  73  73  MET MET B . n 
B 1 65  GLU 65  74  74  GLU GLU B . n 
B 1 66  GLU 66  75  75  GLU GLU B . n 
B 1 67  ARG 67  76  76  ARG ARG B . n 
B 1 68  GLY 68  77  77  GLY GLY B . n 
B 1 69  LEU 69  78  78  LEU LEU B . n 
B 1 70  ALA 70  79  79  ALA ALA B . n 
B 1 71  PRO 71  80  80  PRO PRO B . n 
B 1 72  LYS 72  81  81  LYS LYS B . n 
B 1 73  PHE 73  82  82  PHE PHE B . n 
B 1 74  ASP 74  83  83  ASP ASP B . n 
B 1 75  THR 75  84  84  THR THR B . n 
B 1 76  THR 76  85  85  THR THR B . n 
B 1 77  PHE 77  86  86  PHE PHE B . n 
B 1 78  GLU 78  87  87  GLU GLU B . n 
B 1 79  SER 79  88  88  SER SER B . n 
B 1 80  ALA 80  89  89  ALA ALA B . n 
B 1 81  ARG 81  90  90  ARG ARG B . n 
B 1 82  PRO 82  91  91  PRO PRO B . n 
B 1 83  THR 83  92  92  THR THR B . n 
B 1 84  GLN 84  93  93  GLN GLN B . n 
B 1 85  THR 85  94  94  THR THR B . n 
B 1 86  HIS 86  95  95  HIS HIS B . n 
B 1 87  MET 87  96  96  MET MET B . n 
B 1 88  ALA 88  97  97  ALA ALA B . n 
B 1 89  LEU 89  98  98  LEU LEU B . n 
B 1 90  VAL 90  99  99  VAL VAL B . n 
B 1 91  GLN 91  100 100 GLN GLN B . n 
B 1 92  LEU 92  101 101 LEU LEU B . n 
B 1 93  GLU 93  102 102 GLU GLU B . n 
B 1 94  ARG 94  103 103 ARG ARG B . n 
B 1 95  VAL 95  104 104 VAL VAL B . n 
B 1 96  GLY 96  105 105 GLY GLY B . n 
B 1 97  LEU 97  106 106 LEU LEU B . n 
B 1 98  LEU 98  107 107 LEU LEU B . n 
B 1 99  ARG 99  108 108 ARG ARG B . n 
B 1 100 PHE 100 109 109 PHE PHE B . n 
B 1 101 LEU 101 110 110 LEU LEU B . n 
B 1 102 VAL 102 111 111 VAL VAL B . n 
B 1 103 SER 103 112 112 SER SER B . n 
B 1 104 GLN 104 113 113 GLN GLN B . n 
B 1 105 ASN 105 114 114 ASN ASN B . n 
B 1 106 VAL 106 115 115 VAL VAL B . n 
B 1 107 ASP 107 116 116 ASP ASP B . n 
B 1 108 GLY 108 117 117 GLY GLY B . n 
B 1 109 LEU 109 118 118 LEU LEU B . n 
B 1 110 HIS 110 119 119 HIS HIS B . n 
B 1 111 VAL 111 120 120 VAL VAL B . n 
B 1 112 ARG 112 121 121 ARG ARG B . n 
B 1 113 SER 113 122 122 SER SER B . n 
B 1 114 GLY 114 123 123 GLY GLY B . n 
B 1 115 PHE 115 124 124 PHE PHE B . n 
B 1 116 PRO 116 125 125 PRO PRO B . n 
B 1 117 ARG 117 126 126 ARG ARG B . n 
B 1 118 ASP 118 127 127 ASP ASP B . n 
B 1 119 LYS 119 128 128 LYS LYS B . n 
B 1 120 LEU 120 129 129 LEU LEU B . n 
B 1 121 ALA 121 130 130 ALA ALA B . n 
B 1 122 GLU 122 131 131 GLU GLU B . n 
B 1 123 LEU 123 132 132 LEU LEU B . n 
B 1 124 HIS 124 133 133 HIS HIS B . n 
B 1 125 GLY 125 134 134 GLY GLY B . n 
B 1 126 ASN 126 135 135 ASN ASN B . n 
B 1 127 MET 127 136 136 MET MET B . n 
B 1 128 PHE 128 137 137 PHE PHE B . n 
B 1 129 VAL 129 138 138 VAL VAL B . n 
B 1 130 GLU 130 139 139 GLU GLU B . n 
B 1 131 GLU 131 140 140 GLU GLU B . n 
B 1 132 CYS 132 141 141 CYS CYS B . n 
B 1 133 ALA 133 142 142 ALA ALA B . n 
B 1 134 LYS 134 143 143 LYS LYS B . n 
B 1 135 CYS 135 144 144 CYS CYS B . n 
B 1 136 LYS 136 145 145 LYS LYS B . n 
B 1 137 THR 137 146 146 THR THR B . n 
B 1 138 GLN 138 147 147 GLN GLN B . n 
B 1 139 TYR 139 148 148 TYR TYR B . n 
B 1 140 VAL 140 149 149 VAL VAL B . n 
B 1 141 ARG 141 150 150 ARG ARG B . n 
B 1 142 ASP 142 151 151 ASP ASP B . n 
B 1 143 THR 143 152 152 THR THR B . n 
B 1 144 VAL 144 153 153 VAL VAL B . n 
B 1 145 VAL 145 154 154 VAL VAL B . n 
B 1 146 GLY 146 155 155 GLY GLY B . n 
B 1 147 THR 147 156 156 THR THR B . n 
B 1 148 MET 148 157 157 MET MET B . n 
B 1 149 GLY 149 158 158 GLY GLY B . n 
B 1 150 LEU 150 159 159 LEU LEU B . n 
B 1 151 LYS 151 160 160 LYS LYS B . n 
B 1 152 ALA 152 161 161 ALA ALA B . n 
B 1 153 THR 153 162 162 THR THR B . n 
B 1 154 GLY 154 163 163 GLY GLY B . n 
B 1 155 ARG 155 164 164 ARG ARG B . n 
B 1 156 LEU 156 165 165 LEU LEU B . n 
B 1 157 CYS 157 166 166 CYS CYS B . n 
B 1 158 THR 158 167 167 THR THR B . n 
B 1 159 VAL 159 168 168 VAL VAL B . n 
B 1 160 ALA 160 169 169 ALA ALA B . n 
B 1 161 LYS 161 170 ?   ?   ?   B . n 
B 1 162 ALA 162 171 ?   ?   ?   B . n 
B 1 163 ARG 163 172 ?   ?   ?   B . n 
B 1 164 GLY 164 173 ?   ?   ?   B . n 
B 1 165 LEU 165 174 ?   ?   ?   B . n 
B 1 166 ARG 166 175 ?   ?   ?   B . n 
B 1 167 ALA 167 176 ?   ?   ?   B . n 
B 1 168 CYS 168 177 177 CYS CYS B . n 
B 1 169 ARG 169 178 178 ARG ARG B . n 
B 1 170 GLY 170 179 179 GLY GLY B . n 
B 1 171 GLU 171 180 180 GLU GLU B . n 
B 1 172 LEU 172 181 181 LEU LEU B . n 
B 1 173 ARG 173 182 182 ARG ARG B . n 
B 1 174 ASP 174 183 183 ASP ASP B . n 
B 1 175 THR 175 184 184 THR THR B . n 
B 1 176 ILE 176 185 185 ILE ILE B . n 
B 1 177 LEU 177 186 186 LEU LEU B . n 
B 1 178 ASP 178 187 187 ASP ASP B . n 
B 1 179 TRP 179 188 188 TRP TRP B . n 
B 1 180 GLU 180 189 189 GLU GLU B . n 
B 1 181 ASP 181 190 190 ASP ASP B . n 
B 1 182 SER 182 191 191 SER SER B . n 
B 1 183 LEU 183 192 192 LEU LEU B . n 
B 1 184 PRO 184 193 193 PRO PRO B . n 
B 1 185 ASP 185 194 194 ASP ASP B . n 
B 1 186 ARG 186 195 195 ARG ARG B . n 
B 1 187 ASP 187 196 196 ASP ASP B . n 
B 1 188 LEU 188 197 197 LEU LEU B . n 
B 1 189 ALA 189 198 198 ALA ALA B . n 
B 1 190 LEU 190 199 199 LEU LEU B . n 
B 1 191 ALA 191 200 200 ALA ALA B . n 
B 1 192 ASP 192 201 201 ASP ASP B . n 
B 1 193 GLU 193 202 202 GLU GLU B . n 
B 1 194 ALA 194 203 203 ALA ALA B . n 
B 1 195 SER 195 204 204 SER SER B . n 
B 1 196 ARG 196 205 205 ARG ARG B . n 
B 1 197 ASN 197 206 206 ASN ASN B . n 
B 1 198 ALA 198 207 207 ALA ALA B . n 
B 1 199 ASP 199 208 208 ASP ASP B . n 
B 1 200 LEU 200 209 209 LEU LEU B . n 
B 1 201 SER 201 210 210 SER SER B . n 
B 1 202 ILE 202 211 211 ILE ILE B . n 
B 1 203 THR 203 212 212 THR THR B . n 
B 1 204 LEU 204 213 213 LEU LEU B . n 
B 1 205 GLY 205 214 214 GLY GLY B . n 
B 1 206 THR 206 215 215 THR THR B . n 
B 1 207 SER 207 216 216 SER SER B . n 
B 1 208 LEU 208 217 217 LEU LEU B . n 
B 1 209 GLN 209 218 218 GLN GLN B . n 
B 1 210 ILE 210 219 219 ILE ILE B . n 
B 1 211 ARG 211 220 220 ARG ARG B . n 
B 1 212 PRO 212 221 221 PRO PRO B . n 
B 1 213 SER 213 222 222 SER SER B . n 
B 1 214 GLY 214 223 223 GLY GLY B . n 
B 1 215 ASN 215 224 224 ASN ASN B . n 
B 1 216 LEU 216 225 225 LEU LEU B . n 
B 1 217 PRO 217 226 226 PRO PRO B . n 
B 1 218 LEU 218 227 227 LEU LEU B . n 
B 1 219 ALA 219 228 228 ALA ALA B . n 
B 1 220 THR 220 229 229 THR THR B . n 
B 1 221 LYS 221 230 230 LYS LYS B . n 
B 1 222 ARG 222 231 231 ARG ARG B . n 
B 1 223 ARG 223 232 232 ARG ARG B . n 
B 1 224 GLY 224 233 233 GLY GLY B . n 
B 1 225 GLY 225 234 234 GLY GLY B . n 
B 1 226 ARG 226 235 235 ARG ARG B . n 
B 1 227 LEU 227 236 236 LEU LEU B . n 
B 1 228 VAL 228 237 237 VAL VAL B . n 
B 1 229 ILE 229 238 238 ILE ILE B . n 
B 1 230 VAL 230 239 239 VAL VAL B . n 
B 1 231 ASN 231 240 240 ASN ASN B . n 
B 1 232 LEU 232 241 241 LEU LEU B . n 
B 1 233 GLN 233 242 242 GLN GLN B . n 
B 1 234 PRO 234 243 243 PRO PRO B . n 
B 1 235 THR 235 244 244 THR THR B . n 
B 1 236 LYS 236 245 245 LYS LYS B . n 
B 1 237 HIS 237 246 246 HIS HIS B . n 
B 1 238 ASP 238 247 247 ASP ASP B . n 
B 1 239 ARG 239 248 248 ARG ARG B . n 
B 1 240 HIS 240 249 249 HIS HIS B . n 
B 1 241 ALA 241 250 250 ALA ALA B . n 
B 1 242 ASP 242 251 251 ASP ASP B . n 
B 1 243 LEU 243 252 252 LEU LEU B . n 
B 1 244 ARG 244 253 253 ARG ARG B . n 
B 1 245 ILE 245 254 254 ILE ILE B . n 
B 1 246 HIS 246 255 255 HIS HIS B . n 
B 1 247 GLY 247 256 256 GLY GLY B . n 
B 1 248 TYR 248 257 257 TYR TYR B . n 
B 1 249 VAL 249 258 258 VAL VAL B . n 
B 1 250 ASP 250 259 259 ASP ASP B . n 
B 1 251 GLU 251 260 260 GLU GLU B . n 
B 1 252 VAL 252 261 261 VAL VAL B . n 
B 1 253 MET 253 262 262 MET MET B . n 
B 1 254 THR 254 263 263 THR THR B . n 
B 1 255 ARG 255 264 264 ARG ARG B . n 
B 1 256 LEU 256 265 265 LEU LEU B . n 
B 1 257 MET 257 266 266 MET MET B . n 
B 1 258 LYS 258 267 267 LYS LYS B . n 
B 1 259 HIS 259 268 268 HIS HIS B . n 
B 1 260 LEU 260 269 269 LEU LEU B . n 
B 1 261 GLY 261 270 270 GLY GLY B . n 
B 1 262 LEU 262 271 271 LEU LEU B . n 
B 1 263 GLU 263 272 272 GLU GLU B . n 
B 1 264 ILE 264 273 273 ILE ILE B . n 
B 1 265 PRO 265 274 274 PRO PRO B . n 
B 1 266 ALA 266 275 275 ALA ALA B . n 
B 1 267 TRP 267 276 276 TRP TRP B . n 
B 1 268 ASP 268 277 277 ASP ASP B . n 
B 1 269 GLY 269 278 278 GLY GLY B . n 
B 1 270 PRO 270 279 279 PRO PRO B . n 
B 1 271 ARG 271 280 280 ARG ARG B . n 
B 1 272 VAL 272 281 281 VAL VAL B . n 
B 1 273 LEU 273 282 282 LEU LEU B . n 
B 1 274 GLU 274 283 283 GLU GLU B . n 
B 1 275 ARG 275 284 284 ARG ARG B . n 
B 1 276 ALA 276 285 285 ALA ALA B . n 
B 1 277 LEU 277 286 286 LEU LEU B . n 
B 1 278 PRO 278 287 287 PRO PRO B . n 
B 1 279 PRO 279 288 288 PRO PRO B . n 
B 1 280 LEU 280 289 289 LEU LEU B . n 
B 1 281 PRO 281 290 290 PRO PRO B . n 
B 1 282 ARG 282 291 291 ARG ARG B . n 
B 1 283 PRO 283 292 292 PRO PRO B . n 
B 1 284 PRO 284 293 293 PRO PRO B . n 
B 1 285 THR 285 294 294 THR THR B . n 
B 1 286 PRO 286 295 295 PRO PRO B . n 
B 1 287 LYS 287 296 296 LYS LYS B . n 
B 1 288 LEU 288 297 297 LEU LEU B . n 
B 1 289 GLU 289 298 298 GLU GLU B . n 
B 1 290 PRO 290 299 ?   ?   ?   B . n 
B 1 291 LYS 291 300 ?   ?   ?   B . n 
B 1 292 GLU 292 301 ?   ?   ?   B . n 
B 1 293 GLU 293 302 ?   ?   ?   B . n 
B 1 294 SER 294 303 ?   ?   ?   B . n 
B 1 295 PRO 295 304 ?   ?   ?   B . n 
B 1 296 THR 296 305 ?   ?   ?   B . n 
B 1 297 ARG 297 306 ?   ?   ?   B . n 
B 1 298 ILE 298 307 ?   ?   ?   B . n 
B 1 299 ASN 299 308 ?   ?   ?   B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 AR6 ? ? AR6 ? ? 'SUBJECT OF INVESTIGATION' ? 
2 KDH ? ? KDH ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 ZN  1 401 1   ZN  ZN  A . 
D 3 AR6 1 402 400 AR6 AR6 A . 
E 4 KDH 1 403 301 KDH KDH A . 
F 2 ZN  1 401 2   ZN  ZN  B . 
G 3 AR6 1 402 401 AR6 AR6 B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0267 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZVP 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     91.200 
_cell.length_a_esd                 ? 
_cell.length_b                     91.200 
_cell.length_b_esd                 ? 
_cell.length_c                     143.710 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZVP 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                173 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 63' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZVP 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.76 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.42 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5.7 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '1.6 M (NH4)2SO4, 10% PEG 400, and Bis-Tris buffer pH 5.7' 
_exptl_crystal_grow.pdbx_pH_range   5.3-5.9 
_exptl_crystal_grow.temp            291.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-03-16 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97918 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL10U2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97918 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL10U2 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8ZVP 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.40 
_reflns.d_resolution_low                               45.60 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     26481 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                19.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.164 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.40 
_reflns_shell.d_res_low                                     2.49 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2747 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.124 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.04 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][2]                            0.04 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            -0.09 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               53.908 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.966 
_refine.correlation_coeff_Fo_to_Fc_free          0.934 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZVP 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.50 
_refine.ls_d_res_low                             45.60 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     22302 
_refine.ls_number_reflns_R_free                  1141 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.97 
_refine.ls_percent_reflns_R_free                 4.9 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.15029 
_refine.ls_R_factor_R_free                       0.20524 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.14756 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.081 
_refine.pdbx_overall_ESU_R_Free                  0.050 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             5.118 
_refine.overall_SU_ML                            0.123 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.50 
_refine_hist.d_res_low                        45.60 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               4494 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4387 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         107 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  0.013  4597  ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.017  4377  ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.672  1.658  6253  ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 1.296  1.581  10095 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 7.090  5.000  557   ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 34.399 19.919 247   ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 17.986 15.000 772   ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? 20.172 15.000 50    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.080  0.200  594   ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.007  0.020  5048  ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  1026  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 4.717  5.368  2240  ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 4.718  5.366  2239  ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 6.423  8.046  2793  ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 6.422  8.049  2794  ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 5.141  6.065  2357  ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 5.124  6.048  2353  ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 7.236  8.903  3461  ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 10.315 ?      17510 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 10.314 ?      17511 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.500 
_refine_ls_shell.d_res_low                        2.565 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             74 
_refine_ls_shell.number_reflns_R_work             1639 
_refine_ls_shell.percent_reflns_obs               99.94 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.097 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.150 
# 
_struct.entry_id                     8ZVP 
_struct.title                        'Human SIRT6 in complex with EGCG' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZVP 
_struct_keywords.text            'complex inhibitor Sirtuin, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 2 ? 
G N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    SIR6_HUMAN 
_struct_ref.pdbx_db_accession          Q8N6T7 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;ADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPT
QTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKAR
GLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADL
RIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRIN
;
_struct_ref.pdbx_align_begin           13 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZVP A 4 ? 299 ? Q8N6T7 13 ? 308 ? 13 308 
2 1 8ZVP B 4 ? 299 ? Q8N6T7 13 ? 308 ? 13 308 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZVP PRO A 1 ? UNP Q8N6T7 ? ? 'expression tag' 10 1 
1 8ZVP PHE A 2 ? UNP Q8N6T7 ? ? 'expression tag' 11 2 
1 8ZVP THR A 3 ? UNP Q8N6T7 ? ? 'expression tag' 12 3 
2 8ZVP PRO B 1 ? UNP Q8N6T7 ? ? 'expression tag' 10 4 
2 8ZVP PHE B 2 ? UNP Q8N6T7 ? ? 'expression tag' 11 5 
2 8ZVP THR B 3 ? UNP Q8N6T7 ? ? 'expression tag' 12 6 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   hexameric 
_pdbx_struct_assembly.oligomeric_count     6 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 15670 ? 
1 MORE         -60   ? 
1 'SSA (A^2)'  68970 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000  0.0000000000 0.0000000000 0.0000000000  1.0000000000  
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 2_555 -y,x-y,z  -0.5000000000 -0.8660254038 0.0000000000 0.0000000000 0.8660254038  -0.5000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
3 'crystal symmetry operation' 3_555 -x+y,-x,z -0.5000000000 0.8660254038  0.0000000000 0.0000000000 -0.8660254038 -0.5000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 17  ? SER A 35  ? PRO A 26  SER A 44  1 ? 19 
HELX_P HELX_P2  AA2 ALA A 44  ? GLY A 51  ? ALA A 53  GLY A 60  5 ? 8  
HELX_P HELX_P3  AA3 GLY A 60  ? ARG A 67  ? GLY A 69  ARG A 76  1 ? 8  
HELX_P HELX_P4  AA4 THR A 83  ? VAL A 95  ? THR A 92  VAL A 104 1 ? 13 
HELX_P HELX_P5  AA5 GLY A 108 ? SER A 113 ? GLY A 117 SER A 122 1 ? 6  
HELX_P HELX_P6  AA6 PRO A 116 ? ASP A 118 ? PRO A 125 ASP A 127 5 ? 3  
HELX_P HELX_P7  AA7 PRO A 184 ? ASN A 197 ? PRO A 193 ASN A 206 1 ? 14 
HELX_P HELX_P8  AA8 PRO A 212 ? GLY A 214 ? PRO A 221 GLY A 223 5 ? 3  
HELX_P HELX_P9  AA9 ASN A 215 ? ARG A 222 ? ASN A 224 ARG A 231 1 ? 8  
HELX_P HELX_P10 AB1 ARG A 223 ? GLY A 225 ? ARG A 232 GLY A 234 5 ? 3  
HELX_P HELX_P11 AB2 HIS A 237 ? ALA A 241 ? HIS A 246 ALA A 250 5 ? 5  
HELX_P HELX_P12 AB3 TYR A 248 ? GLY A 261 ? TYR A 257 GLY A 270 1 ? 14 
HELX_P HELX_P13 AB4 PRO B 17  ? SER B 35  ? PRO B 26  SER B 44  1 ? 19 
HELX_P HELX_P14 AB5 ALA B 44  ? GLY B 51  ? ALA B 53  GLY B 60  5 ? 8  
HELX_P HELX_P15 AB6 GLY B 60  ? ARG B 67  ? GLY B 69  ARG B 76  1 ? 8  
HELX_P HELX_P16 AB7 THR B 83  ? VAL B 95  ? THR B 92  VAL B 104 1 ? 13 
HELX_P HELX_P17 AB8 GLY B 108 ? SER B 113 ? GLY B 117 SER B 122 1 ? 6  
HELX_P HELX_P18 AB9 PRO B 116 ? ASP B 118 ? PRO B 125 ASP B 127 5 ? 3  
HELX_P HELX_P19 AC1 PRO B 184 ? ASN B 197 ? PRO B 193 ASN B 206 1 ? 14 
HELX_P HELX_P20 AC2 ILE B 210 ? ARG B 222 ? ILE B 219 ARG B 231 1 ? 13 
HELX_P HELX_P21 AC3 ARG B 223 ? GLY B 225 ? ARG B 232 GLY B 234 5 ? 3  
HELX_P HELX_P22 AC4 HIS B 237 ? ALA B 241 ? HIS B 246 ALA B 250 5 ? 5  
HELX_P HELX_P23 AC5 TYR B 248 ? GLY B 261 ? TYR B 257 GLY B 270 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A CYS 132 SG ? ? ? 1_555 C ZN . ZN ? ? A CYS 141 A ZN 401 1_555 ? ? ? ? ? ? ? 2.348 ? ? 
metalc2 metalc ? ? A CYS 157 SG ? ? ? 1_555 C ZN . ZN ? ? A CYS 166 A ZN 401 1_555 ? ? ? ? ? ? ? 2.333 ? ? 
metalc3 metalc ? ? A CYS 168 SG ? ? ? 1_555 C ZN . ZN ? ? A CYS 177 A ZN 401 1_555 ? ? ? ? ? ? ? 2.622 ? ? 
metalc4 metalc ? ? B CYS 132 SG ? ? ? 1_555 F ZN . ZN ? ? B CYS 141 B ZN 401 1_555 ? ? ? ? ? ? ? 2.212 ? ? 
metalc5 metalc ? ? B CYS 135 SG ? ? ? 1_555 F ZN . ZN ? ? B CYS 144 B ZN 401 1_555 ? ? ? ? ? ? ? 2.190 ? ? 
metalc6 metalc ? ? B CYS 157 SG ? ? ? 1_555 F ZN . ZN ? ? B CYS 166 B ZN 401 1_555 ? ? ? ? ? ? ? 2.708 ? ? 
metalc7 metalc ? ? B CYS 168 SG ? ? ? 1_555 F ZN . ZN ? ? B CYS 177 B ZN 401 1_555 ? ? ? ? ? ? ? 2.999 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1 SG ? A CYS 132 ? A CYS 141 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 SG ? A CYS 157 ? A CYS 166 ? 1_555 102.9 ? 
2 SG ? A CYS 132 ? A CYS 141 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 SG ? A CYS 168 ? A CYS 177 ? 1_555 94.9  ? 
3 SG ? A CYS 157 ? A CYS 166 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 SG ? A CYS 168 ? A CYS 177 ? 1_555 103.6 ? 
4 SG ? B CYS 132 ? B CYS 141 ? 1_555 ZN ? F ZN . ? B ZN 401 ? 1_555 SG ? B CYS 135 ? B CYS 144 ? 1_555 133.4 ? 
5 SG ? B CYS 132 ? B CYS 141 ? 1_555 ZN ? F ZN . ? B ZN 401 ? 1_555 SG ? B CYS 157 ? B CYS 166 ? 1_555 108.5 ? 
6 SG ? B CYS 135 ? B CYS 144 ? 1_555 ZN ? F ZN . ? B ZN 401 ? 1_555 SG ? B CYS 157 ? B CYS 166 ? 1_555 102.4 ? 
7 SG ? B CYS 132 ? B CYS 141 ? 1_555 ZN ? F ZN . ? B ZN 401 ? 1_555 SG ? B CYS 168 ? B CYS 177 ? 1_555 102.8 ? 
8 SG ? B CYS 135 ? B CYS 144 ? 1_555 ZN ? F ZN . ? B ZN 401 ? 1_555 SG ? B CYS 168 ? B CYS 177 ? 1_555 116.3 ? 
9 SG ? B CYS 157 ? B CYS 166 ? 1_555 ZN ? F ZN . ? B ZN 401 ? 1_555 SG ? B CYS 168 ? B CYS 177 ? 1_555 80.4  ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 4 ? 
AA3 ? 6 ? 
AA4 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? parallel      
AA3 3 4 ? parallel      
AA3 4 5 ? parallel      
AA3 5 6 ? parallel      
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LEU A 120 ? GLU A 122 ? LEU A 129 GLU A 131 
AA1 2 PHE A 100 ? SER A 103 ? PHE A 109 SER A 112 
AA1 3 VAL A 38  ? THR A 42  ? VAL A 47  THR A 51  
AA1 4 LEU A 200 ? LEU A 204 ? LEU A 209 LEU A 213 
AA1 5 ARG A 226 ? VAL A 230 ? ARG A 235 VAL A 239 
AA1 6 LEU A 243 ? ILE A 245 ? LEU A 252 ILE A 254 
AA2 1 GLN A 138 ? VAL A 140 ? GLN A 147 VAL A 149 
AA2 2 VAL A 129 ? CYS A 132 ? VAL A 138 CYS A 141 
AA2 3 GLU A 171 ? ASP A 174 ? GLU A 180 ASP A 183 
AA2 4 ALA A 152 ? LEU A 156 ? ALA A 161 LEU A 165 
AA3 1 LEU B 120 ? GLU B 122 ? LEU B 129 GLU B 131 
AA3 2 PHE B 100 ? SER B 103 ? PHE B 109 SER B 112 
AA3 3 VAL B 38  ? THR B 42  ? VAL B 47  THR B 51  
AA3 4 LEU B 200 ? LEU B 204 ? LEU B 209 LEU B 213 
AA3 5 ARG B 226 ? VAL B 230 ? ARG B 235 VAL B 239 
AA3 6 LEU B 243 ? ILE B 245 ? LEU B 252 ILE B 254 
AA4 1 GLN B 138 ? VAL B 140 ? GLN B 147 VAL B 149 
AA4 2 VAL B 129 ? CYS B 132 ? VAL B 138 CYS B 141 
AA4 3 GLU B 171 ? ASP B 174 ? GLU B 180 ASP B 183 
AA4 4 ALA B 152 ? LEU B 156 ? ALA B 161 LEU B 165 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O ALA A 121 ? O ALA A 130 N LEU A 101 ? N LEU A 110 
AA1 2 3 O VAL A 102 ? O VAL A 111 N PHE A 40  ? N PHE A 49  
AA1 3 4 N HIS A 41  ? N HIS A 50  O LEU A 204 ? O LEU A 213 
AA1 4 5 N THR A 203 ? N THR A 212 O VAL A 230 ? O VAL A 239 
AA1 5 6 N ILE A 229 ? N ILE A 238 O ILE A 245 ? O ILE A 254 
AA2 1 2 O TYR A 139 ? O TYR A 148 N GLU A 130 ? N GLU A 139 
AA2 2 3 N GLU A 131 ? N GLU A 140 O ARG A 173 ? O ARG A 182 
AA2 3 4 O LEU A 172 ? O LEU A 181 N ARG A 155 ? N ARG A 164 
AA3 1 2 O ALA B 121 ? O ALA B 130 N SER B 103 ? N SER B 112 
AA3 2 3 O VAL B 102 ? O VAL B 111 N PHE B 40  ? N PHE B 49  
AA3 3 4 N HIS B 41  ? N HIS B 50  O LEU B 204 ? O LEU B 213 
AA3 4 5 N SER B 201 ? N SER B 210 O VAL B 228 ? O VAL B 237 
AA3 5 6 N ILE B 229 ? N ILE B 238 O ILE B 245 ? O ILE B 254 
AA4 1 2 O TYR B 139 ? O TYR B 148 N GLU B 130 ? N GLU B 139 
AA4 2 3 N GLU B 131 ? N GLU B 140 O ARG B 173 ? O ARG B 182 
AA4 3 4 O LEU B 172 ? O LEU B 181 N THR B 153 ? N THR B 162 
# 
_pdbx_entry_details.entry_id                   8ZVP 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LEU A 20  ? ? -46.40  154.45 
2 1 SER A 46  ? ? -163.39 92.46  
3 1 PRO A 243 ? ? -49.72  160.68 
4 1 LYS B 143 ? ? -95.91  -68.98 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A LYS 170 ? A LYS 161 
2  1 Y 1 A ALA 171 ? A ALA 162 
3  1 Y 1 A ARG 172 ? A ARG 163 
4  1 Y 1 A GLY 173 ? A GLY 164 
5  1 Y 1 A LEU 174 ? A LEU 165 
6  1 Y 1 A ARG 175 ? A ARG 166 
7  1 Y 1 A ALA 176 ? A ALA 167 
8  1 Y 1 A PRO 299 ? A PRO 290 
9  1 Y 1 A LYS 300 ? A LYS 291 
10 1 Y 1 A GLU 301 ? A GLU 292 
11 1 Y 1 A GLU 302 ? A GLU 293 
12 1 Y 1 A SER 303 ? A SER 294 
13 1 Y 1 A PRO 304 ? A PRO 295 
14 1 Y 1 A THR 305 ? A THR 296 
15 1 Y 1 A ARG 306 ? A ARG 297 
16 1 Y 1 A ILE 307 ? A ILE 298 
17 1 Y 1 A ASN 308 ? A ASN 299 
18 1 Y 1 B PRO 10  ? B PRO 1   
19 1 Y 1 B PHE 11  ? B PHE 2   
20 1 Y 1 B THR 12  ? B THR 3   
21 1 Y 1 B LYS 170 ? B LYS 161 
22 1 Y 1 B ALA 171 ? B ALA 162 
23 1 Y 1 B ARG 172 ? B ARG 163 
24 1 Y 1 B GLY 173 ? B GLY 164 
25 1 Y 1 B LEU 174 ? B LEU 165 
26 1 Y 1 B ARG 175 ? B ARG 166 
27 1 Y 1 B ALA 176 ? B ALA 167 
28 1 Y 1 B PRO 299 ? B PRO 290 
29 1 Y 1 B LYS 300 ? B LYS 291 
30 1 Y 1 B GLU 301 ? B GLU 292 
31 1 Y 1 B GLU 302 ? B GLU 293 
32 1 Y 1 B SER 303 ? B SER 294 
33 1 Y 1 B PRO 304 ? B PRO 295 
34 1 Y 1 B THR 305 ? B THR 296 
35 1 Y 1 B ARG 306 ? B ARG 297 
36 1 Y 1 B ILE 307 ? B ILE 298 
37 1 Y 1 B ASN 308 ? B ASN 299 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N  N N 1   
ALA CA     C  N S 2   
ALA C      C  N N 3   
ALA O      O  N N 4   
ALA CB     C  N N 5   
ALA OXT    O  N N 6   
ALA H      H  N N 7   
ALA H2     H  N N 8   
ALA HA     H  N N 9   
ALA HB1    H  N N 10  
ALA HB2    H  N N 11  
ALA HB3    H  N N 12  
ALA HXT    H  N N 13  
AR6 N1     N  Y N 14  
AR6 C2     C  Y N 15  
AR6 N3     N  Y N 16  
AR6 C4     C  Y N 17  
AR6 C5     C  Y N 18  
AR6 C6     C  Y N 19  
AR6 N6     N  N N 20  
AR6 N7     N  Y N 21  
AR6 C8     C  Y N 22  
AR6 N9     N  Y N 23  
AR6 PA     P  N N 24  
AR6 PB     P  N N 25  
AR6 "C1'"  C  N R 26  
AR6 O1A    O  N N 27  
AR6 O1B    O  N N 28  
AR6 C1D    C  N S 29  
AR6 O1D    O  N N 30  
AR6 "C2'"  C  N R 31  
AR6 "O2'"  O  N N 32  
AR6 O2A    O  N N 33  
AR6 O2B    O  N N 34  
AR6 C2D    C  N R 35  
AR6 O2D    O  N N 36  
AR6 "C3'"  C  N S 37  
AR6 "O3'"  O  N N 38  
AR6 O3A    O  N N 39  
AR6 C3D    C  N S 40  
AR6 O3D    O  N N 41  
AR6 "C4'"  C  N R 42  
AR6 "O4'"  O  N N 43  
AR6 C4D    C  N R 44  
AR6 O4D    O  N N 45  
AR6 "C5'"  C  N N 46  
AR6 "O5'"  O  N N 47  
AR6 C5D    C  N N 48  
AR6 O5D    O  N N 49  
AR6 H2     H  N N 50  
AR6 HN6    H  N N 51  
AR6 HN6A   H  N N 52  
AR6 H8     H  N N 53  
AR6 "H1'"  H  N N 54  
AR6 H1D    H  N N 55  
AR6 "H2'"  H  N N 56  
AR6 "HO2'" H  N N 57  
AR6 H2D    H  N N 58  
AR6 HO2D   H  N N 59  
AR6 "H3'"  H  N N 60  
AR6 "HO3'" H  N N 61  
AR6 H3D    H  N N 62  
AR6 HO3D   H  N N 63  
AR6 "H4'"  H  N N 64  
AR6 H4D    H  N N 65  
AR6 "H5'"  H  N N 66  
AR6 "H5'A" H  N N 67  
AR6 H5D    H  N N 68  
AR6 H5DA   H  N N 69  
AR6 H1A    H  N N 70  
AR6 H1B    H  N N 71  
AR6 HD1    H  N N 72  
ARG N      N  N N 73  
ARG CA     C  N S 74  
ARG C      C  N N 75  
ARG O      O  N N 76  
ARG CB     C  N N 77  
ARG CG     C  N N 78  
ARG CD     C  N N 79  
ARG NE     N  N N 80  
ARG CZ     C  N N 81  
ARG NH1    N  N N 82  
ARG NH2    N  N N 83  
ARG OXT    O  N N 84  
ARG H      H  N N 85  
ARG H2     H  N N 86  
ARG HA     H  N N 87  
ARG HB2    H  N N 88  
ARG HB3    H  N N 89  
ARG HG2    H  N N 90  
ARG HG3    H  N N 91  
ARG HD2    H  N N 92  
ARG HD3    H  N N 93  
ARG HE     H  N N 94  
ARG HH11   H  N N 95  
ARG HH12   H  N N 96  
ARG HH21   H  N N 97  
ARG HH22   H  N N 98  
ARG HXT    H  N N 99  
ASN N      N  N N 100 
ASN CA     C  N S 101 
ASN C      C  N N 102 
ASN O      O  N N 103 
ASN CB     C  N N 104 
ASN CG     C  N N 105 
ASN OD1    O  N N 106 
ASN ND2    N  N N 107 
ASN OXT    O  N N 108 
ASN H      H  N N 109 
ASN H2     H  N N 110 
ASN HA     H  N N 111 
ASN HB2    H  N N 112 
ASN HB3    H  N N 113 
ASN HD21   H  N N 114 
ASN HD22   H  N N 115 
ASN HXT    H  N N 116 
ASP N      N  N N 117 
ASP CA     C  N S 118 
ASP C      C  N N 119 
ASP O      O  N N 120 
ASP CB     C  N N 121 
ASP CG     C  N N 122 
ASP OD1    O  N N 123 
ASP OD2    O  N N 124 
ASP OXT    O  N N 125 
ASP H      H  N N 126 
ASP H2     H  N N 127 
ASP HA     H  N N 128 
ASP HB2    H  N N 129 
ASP HB3    H  N N 130 
ASP HD2    H  N N 131 
ASP HXT    H  N N 132 
CYS N      N  N N 133 
CYS CA     C  N R 134 
CYS C      C  N N 135 
CYS O      O  N N 136 
CYS CB     C  N N 137 
CYS SG     S  N N 138 
CYS OXT    O  N N 139 
CYS H      H  N N 140 
CYS H2     H  N N 141 
CYS HA     H  N N 142 
CYS HB2    H  N N 143 
CYS HB3    H  N N 144 
CYS HG     H  N N 145 
CYS HXT    H  N N 146 
GLN N      N  N N 147 
GLN CA     C  N S 148 
GLN C      C  N N 149 
GLN O      O  N N 150 
GLN CB     C  N N 151 
GLN CG     C  N N 152 
GLN CD     C  N N 153 
GLN OE1    O  N N 154 
GLN NE2    N  N N 155 
GLN OXT    O  N N 156 
GLN H      H  N N 157 
GLN H2     H  N N 158 
GLN HA     H  N N 159 
GLN HB2    H  N N 160 
GLN HB3    H  N N 161 
GLN HG2    H  N N 162 
GLN HG3    H  N N 163 
GLN HE21   H  N N 164 
GLN HE22   H  N N 165 
GLN HXT    H  N N 166 
GLU N      N  N N 167 
GLU CA     C  N S 168 
GLU C      C  N N 169 
GLU O      O  N N 170 
GLU CB     C  N N 171 
GLU CG     C  N N 172 
GLU CD     C  N N 173 
GLU OE1    O  N N 174 
GLU OE2    O  N N 175 
GLU OXT    O  N N 176 
GLU H      H  N N 177 
GLU H2     H  N N 178 
GLU HA     H  N N 179 
GLU HB2    H  N N 180 
GLU HB3    H  N N 181 
GLU HG2    H  N N 182 
GLU HG3    H  N N 183 
GLU HE2    H  N N 184 
GLU HXT    H  N N 185 
GLY N      N  N N 186 
GLY CA     C  N N 187 
GLY C      C  N N 188 
GLY O      O  N N 189 
GLY OXT    O  N N 190 
GLY H      H  N N 191 
GLY H2     H  N N 192 
GLY HA2    H  N N 193 
GLY HA3    H  N N 194 
GLY HXT    H  N N 195 
HIS N      N  N N 196 
HIS CA     C  N S 197 
HIS C      C  N N 198 
HIS O      O  N N 199 
HIS CB     C  N N 200 
HIS CG     C  Y N 201 
HIS ND1    N  Y N 202 
HIS CD2    C  Y N 203 
HIS CE1    C  Y N 204 
HIS NE2    N  Y N 205 
HIS OXT    O  N N 206 
HIS H      H  N N 207 
HIS H2     H  N N 208 
HIS HA     H  N N 209 
HIS HB2    H  N N 210 
HIS HB3    H  N N 211 
HIS HD1    H  N N 212 
HIS HD2    H  N N 213 
HIS HE1    H  N N 214 
HIS HE2    H  N N 215 
HIS HXT    H  N N 216 
ILE N      N  N N 217 
ILE CA     C  N S 218 
ILE C      C  N N 219 
ILE O      O  N N 220 
ILE CB     C  N S 221 
ILE CG1    C  N N 222 
ILE CG2    C  N N 223 
ILE CD1    C  N N 224 
ILE OXT    O  N N 225 
ILE H      H  N N 226 
ILE H2     H  N N 227 
ILE HA     H  N N 228 
ILE HB     H  N N 229 
ILE HG12   H  N N 230 
ILE HG13   H  N N 231 
ILE HG21   H  N N 232 
ILE HG22   H  N N 233 
ILE HG23   H  N N 234 
ILE HD11   H  N N 235 
ILE HD12   H  N N 236 
ILE HD13   H  N N 237 
ILE HXT    H  N N 238 
KDH O1     O  N N 239 
KDH C3     C  Y N 240 
KDH C6     C  Y N 241 
KDH O7     O  N N 242 
KDH C9     C  Y N 243 
KDH O10    O  N N 244 
KDH C12    C  Y N 245 
KDH C14    C  Y N 246 
KDH C15    C  N R 247 
KDH C20    C  Y N 248 
KDH C21    C  Y N 249 
KDH C24    C  Y N 250 
KDH C26    C  Y N 251 
KDH C29    C  Y N 252 
KDH C31    C  Y N 253 
KDH C33    C  N R 254 
KDH C36    C  N N 255 
KDH C38    C  Y N 256 
KDH C39    C  Y N 257 
KDH C41    C  Y N 258 
KDH C01    C  N N 259 
KDH O01    O  N N 260 
KDH O02    O  N N 261 
KDH O03    O  N N 262 
KDH C4     C  Y N 263 
KDH O35    O  N N 264 
KDH O37    O  N N 265 
KDH C43    C  Y N 266 
KDH O44    O  N N 267 
KDH C46    C  Y N 268 
KDH O47    O  N N 269 
KDH C49    C  Y N 270 
KDH O50    O  N N 271 
KDH HO1    H  N N 272 
KDH H21    H  N N 273 
KDH H33    H  N N 274 
KDH H4     H  N N 275 
KDH HO7    H  N N 276 
KDH H01    H  N N 277 
KDH H01A   H  N N 278 
KDH HO03   H  N N 279 
KDH HO10   H  N N 280 
KDH H12    H  N N 281 
KDH H15    H  N N 282 
KDH H26    H  N N 283 
KDH H39    H  N N 284 
KDH H41    H  N N 285 
KDH HO02   H  N N 286 
KDH HO44   H  N N 287 
KDH HO47   H  N N 288 
KDH HO50   H  N N 289 
LEU N      N  N N 290 
LEU CA     C  N S 291 
LEU C      C  N N 292 
LEU O      O  N N 293 
LEU CB     C  N N 294 
LEU CG     C  N N 295 
LEU CD1    C  N N 296 
LEU CD2    C  N N 297 
LEU OXT    O  N N 298 
LEU H      H  N N 299 
LEU H2     H  N N 300 
LEU HA     H  N N 301 
LEU HB2    H  N N 302 
LEU HB3    H  N N 303 
LEU HG     H  N N 304 
LEU HD11   H  N N 305 
LEU HD12   H  N N 306 
LEU HD13   H  N N 307 
LEU HD21   H  N N 308 
LEU HD22   H  N N 309 
LEU HD23   H  N N 310 
LEU HXT    H  N N 311 
LYS N      N  N N 312 
LYS CA     C  N S 313 
LYS C      C  N N 314 
LYS O      O  N N 315 
LYS CB     C  N N 316 
LYS CG     C  N N 317 
LYS CD     C  N N 318 
LYS CE     C  N N 319 
LYS NZ     N  N N 320 
LYS OXT    O  N N 321 
LYS H      H  N N 322 
LYS H2     H  N N 323 
LYS HA     H  N N 324 
LYS HB2    H  N N 325 
LYS HB3    H  N N 326 
LYS HG2    H  N N 327 
LYS HG3    H  N N 328 
LYS HD2    H  N N 329 
LYS HD3    H  N N 330 
LYS HE2    H  N N 331 
LYS HE3    H  N N 332 
LYS HZ1    H  N N 333 
LYS HZ2    H  N N 334 
LYS HZ3    H  N N 335 
LYS HXT    H  N N 336 
MET N      N  N N 337 
MET CA     C  N S 338 
MET C      C  N N 339 
MET O      O  N N 340 
MET CB     C  N N 341 
MET CG     C  N N 342 
MET SD     S  N N 343 
MET CE     C  N N 344 
MET OXT    O  N N 345 
MET H      H  N N 346 
MET H2     H  N N 347 
MET HA     H  N N 348 
MET HB2    H  N N 349 
MET HB3    H  N N 350 
MET HG2    H  N N 351 
MET HG3    H  N N 352 
MET HE1    H  N N 353 
MET HE2    H  N N 354 
MET HE3    H  N N 355 
MET HXT    H  N N 356 
PHE N      N  N N 357 
PHE CA     C  N S 358 
PHE C      C  N N 359 
PHE O      O  N N 360 
PHE CB     C  N N 361 
PHE CG     C  Y N 362 
PHE CD1    C  Y N 363 
PHE CD2    C  Y N 364 
PHE CE1    C  Y N 365 
PHE CE2    C  Y N 366 
PHE CZ     C  Y N 367 
PHE OXT    O  N N 368 
PHE H      H  N N 369 
PHE H2     H  N N 370 
PHE HA     H  N N 371 
PHE HB2    H  N N 372 
PHE HB3    H  N N 373 
PHE HD1    H  N N 374 
PHE HD2    H  N N 375 
PHE HE1    H  N N 376 
PHE HE2    H  N N 377 
PHE HZ     H  N N 378 
PHE HXT    H  N N 379 
PRO N      N  N N 380 
PRO CA     C  N S 381 
PRO C      C  N N 382 
PRO O      O  N N 383 
PRO CB     C  N N 384 
PRO CG     C  N N 385 
PRO CD     C  N N 386 
PRO OXT    O  N N 387 
PRO H      H  N N 388 
PRO HA     H  N N 389 
PRO HB2    H  N N 390 
PRO HB3    H  N N 391 
PRO HG2    H  N N 392 
PRO HG3    H  N N 393 
PRO HD2    H  N N 394 
PRO HD3    H  N N 395 
PRO HXT    H  N N 396 
SER N      N  N N 397 
SER CA     C  N S 398 
SER C      C  N N 399 
SER O      O  N N 400 
SER CB     C  N N 401 
SER OG     O  N N 402 
SER OXT    O  N N 403 
SER H      H  N N 404 
SER H2     H  N N 405 
SER HA     H  N N 406 
SER HB2    H  N N 407 
SER HB3    H  N N 408 
SER HG     H  N N 409 
SER HXT    H  N N 410 
THR N      N  N N 411 
THR CA     C  N S 412 
THR C      C  N N 413 
THR O      O  N N 414 
THR CB     C  N R 415 
THR OG1    O  N N 416 
THR CG2    C  N N 417 
THR OXT    O  N N 418 
THR H      H  N N 419 
THR H2     H  N N 420 
THR HA     H  N N 421 
THR HB     H  N N 422 
THR HG1    H  N N 423 
THR HG21   H  N N 424 
THR HG22   H  N N 425 
THR HG23   H  N N 426 
THR HXT    H  N N 427 
TRP N      N  N N 428 
TRP CA     C  N S 429 
TRP C      C  N N 430 
TRP O      O  N N 431 
TRP CB     C  N N 432 
TRP CG     C  Y N 433 
TRP CD1    C  Y N 434 
TRP CD2    C  Y N 435 
TRP NE1    N  Y N 436 
TRP CE2    C  Y N 437 
TRP CE3    C  Y N 438 
TRP CZ2    C  Y N 439 
TRP CZ3    C  Y N 440 
TRP CH2    C  Y N 441 
TRP OXT    O  N N 442 
TRP H      H  N N 443 
TRP H2     H  N N 444 
TRP HA     H  N N 445 
TRP HB2    H  N N 446 
TRP HB3    H  N N 447 
TRP HD1    H  N N 448 
TRP HE1    H  N N 449 
TRP HE3    H  N N 450 
TRP HZ2    H  N N 451 
TRP HZ3    H  N N 452 
TRP HH2    H  N N 453 
TRP HXT    H  N N 454 
TYR N      N  N N 455 
TYR CA     C  N S 456 
TYR C      C  N N 457 
TYR O      O  N N 458 
TYR CB     C  N N 459 
TYR CG     C  Y N 460 
TYR CD1    C  Y N 461 
TYR CD2    C  Y N 462 
TYR CE1    C  Y N 463 
TYR CE2    C  Y N 464 
TYR CZ     C  Y N 465 
TYR OH     O  N N 466 
TYR OXT    O  N N 467 
TYR H      H  N N 468 
TYR H2     H  N N 469 
TYR HA     H  N N 470 
TYR HB2    H  N N 471 
TYR HB3    H  N N 472 
TYR HD1    H  N N 473 
TYR HD2    H  N N 474 
TYR HE1    H  N N 475 
TYR HE2    H  N N 476 
TYR HH     H  N N 477 
TYR HXT    H  N N 478 
VAL N      N  N N 479 
VAL CA     C  N S 480 
VAL C      C  N N 481 
VAL O      O  N N 482 
VAL CB     C  N N 483 
VAL CG1    C  N N 484 
VAL CG2    C  N N 485 
VAL OXT    O  N N 486 
VAL H      H  N N 487 
VAL H2     H  N N 488 
VAL HA     H  N N 489 
VAL HB     H  N N 490 
VAL HG11   H  N N 491 
VAL HG12   H  N N 492 
VAL HG13   H  N N 493 
VAL HG21   H  N N 494 
VAL HG22   H  N N 495 
VAL HG23   H  N N 496 
VAL HXT    H  N N 497 
ZN  ZN     ZN N N 498 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
AR6 N1    C2     doub Y N 13  
AR6 N1    C6     sing Y N 14  
AR6 C2    N3     sing Y N 15  
AR6 N3    C4     doub Y N 16  
AR6 C4    C5     sing Y N 17  
AR6 C4    N9     sing Y N 18  
AR6 C5    C6     doub Y N 19  
AR6 C5    N7     sing Y N 20  
AR6 C6    N6     sing N N 21  
AR6 N7    C8     doub Y N 22  
AR6 C8    N9     sing Y N 23  
AR6 N9    "C1'"  sing N N 24  
AR6 PA    O1A    sing N N 25  
AR6 PA    O2A    doub N N 26  
AR6 PA    O3A    sing N N 27  
AR6 PA    "O5'"  sing N N 28  
AR6 PB    O1B    sing N N 29  
AR6 PB    O2B    doub N N 30  
AR6 PB    O3A    sing N N 31  
AR6 PB    O5D    sing N N 32  
AR6 "C1'" "C2'"  sing N N 33  
AR6 "C1'" "O4'"  sing N N 34  
AR6 C1D   O1D    sing N N 35  
AR6 C1D   C2D    sing N N 36  
AR6 C1D   O4D    sing N N 37  
AR6 "C2'" "O2'"  sing N N 38  
AR6 "C2'" "C3'"  sing N N 39  
AR6 C2D   O2D    sing N N 40  
AR6 C2D   C3D    sing N N 41  
AR6 "C3'" "O3'"  sing N N 42  
AR6 "C3'" "C4'"  sing N N 43  
AR6 C3D   O3D    sing N N 44  
AR6 C3D   C4D    sing N N 45  
AR6 "C4'" "O4'"  sing N N 46  
AR6 "C4'" "C5'"  sing N N 47  
AR6 C4D   O4D    sing N N 48  
AR6 C4D   C5D    sing N N 49  
AR6 "C5'" "O5'"  sing N N 50  
AR6 C5D   O5D    sing N N 51  
AR6 C2    H2     sing N N 52  
AR6 N6    HN6    sing N N 53  
AR6 N6    HN6A   sing N N 54  
AR6 C8    H8     sing N N 55  
AR6 "C1'" "H1'"  sing N N 56  
AR6 C1D   H1D    sing N N 57  
AR6 "C2'" "H2'"  sing N N 58  
AR6 "O2'" "HO2'" sing N N 59  
AR6 C2D   H2D    sing N N 60  
AR6 O2D   HO2D   sing N N 61  
AR6 "C3'" "H3'"  sing N N 62  
AR6 "O3'" "HO3'" sing N N 63  
AR6 C3D   H3D    sing N N 64  
AR6 O3D   HO3D   sing N N 65  
AR6 "C4'" "H4'"  sing N N 66  
AR6 C4D   H4D    sing N N 67  
AR6 "C5'" "H5'"  sing N N 68  
AR6 "C5'" "H5'A" sing N N 69  
AR6 C5D   H5D    sing N N 70  
AR6 C5D   H5DA   sing N N 71  
AR6 O1A   H1A    sing N N 72  
AR6 O1B   H1B    sing N N 73  
AR6 O1D   HD1    sing N N 74  
ARG N     CA     sing N N 75  
ARG N     H      sing N N 76  
ARG N     H2     sing N N 77  
ARG CA    C      sing N N 78  
ARG CA    CB     sing N N 79  
ARG CA    HA     sing N N 80  
ARG C     O      doub N N 81  
ARG C     OXT    sing N N 82  
ARG CB    CG     sing N N 83  
ARG CB    HB2    sing N N 84  
ARG CB    HB3    sing N N 85  
ARG CG    CD     sing N N 86  
ARG CG    HG2    sing N N 87  
ARG CG    HG3    sing N N 88  
ARG CD    NE     sing N N 89  
ARG CD    HD2    sing N N 90  
ARG CD    HD3    sing N N 91  
ARG NE    CZ     sing N N 92  
ARG NE    HE     sing N N 93  
ARG CZ    NH1    sing N N 94  
ARG CZ    NH2    doub N N 95  
ARG NH1   HH11   sing N N 96  
ARG NH1   HH12   sing N N 97  
ARG NH2   HH21   sing N N 98  
ARG NH2   HH22   sing N N 99  
ARG OXT   HXT    sing N N 100 
ASN N     CA     sing N N 101 
ASN N     H      sing N N 102 
ASN N     H2     sing N N 103 
ASN CA    C      sing N N 104 
ASN CA    CB     sing N N 105 
ASN CA    HA     sing N N 106 
ASN C     O      doub N N 107 
ASN C     OXT    sing N N 108 
ASN CB    CG     sing N N 109 
ASN CB    HB2    sing N N 110 
ASN CB    HB3    sing N N 111 
ASN CG    OD1    doub N N 112 
ASN CG    ND2    sing N N 113 
ASN ND2   HD21   sing N N 114 
ASN ND2   HD22   sing N N 115 
ASN OXT   HXT    sing N N 116 
ASP N     CA     sing N N 117 
ASP N     H      sing N N 118 
ASP N     H2     sing N N 119 
ASP CA    C      sing N N 120 
ASP CA    CB     sing N N 121 
ASP CA    HA     sing N N 122 
ASP C     O      doub N N 123 
ASP C     OXT    sing N N 124 
ASP CB    CG     sing N N 125 
ASP CB    HB2    sing N N 126 
ASP CB    HB3    sing N N 127 
ASP CG    OD1    doub N N 128 
ASP CG    OD2    sing N N 129 
ASP OD2   HD2    sing N N 130 
ASP OXT   HXT    sing N N 131 
CYS N     CA     sing N N 132 
CYS N     H      sing N N 133 
CYS N     H2     sing N N 134 
CYS CA    C      sing N N 135 
CYS CA    CB     sing N N 136 
CYS CA    HA     sing N N 137 
CYS C     O      doub N N 138 
CYS C     OXT    sing N N 139 
CYS CB    SG     sing N N 140 
CYS CB    HB2    sing N N 141 
CYS CB    HB3    sing N N 142 
CYS SG    HG     sing N N 143 
CYS OXT   HXT    sing N N 144 
GLN N     CA     sing N N 145 
GLN N     H      sing N N 146 
GLN N     H2     sing N N 147 
GLN CA    C      sing N N 148 
GLN CA    CB     sing N N 149 
GLN CA    HA     sing N N 150 
GLN C     O      doub N N 151 
GLN C     OXT    sing N N 152 
GLN CB    CG     sing N N 153 
GLN CB    HB2    sing N N 154 
GLN CB    HB3    sing N N 155 
GLN CG    CD     sing N N 156 
GLN CG    HG2    sing N N 157 
GLN CG    HG3    sing N N 158 
GLN CD    OE1    doub N N 159 
GLN CD    NE2    sing N N 160 
GLN NE2   HE21   sing N N 161 
GLN NE2   HE22   sing N N 162 
GLN OXT   HXT    sing N N 163 
GLU N     CA     sing N N 164 
GLU N     H      sing N N 165 
GLU N     H2     sing N N 166 
GLU CA    C      sing N N 167 
GLU CA    CB     sing N N 168 
GLU CA    HA     sing N N 169 
GLU C     O      doub N N 170 
GLU C     OXT    sing N N 171 
GLU CB    CG     sing N N 172 
GLU CB    HB2    sing N N 173 
GLU CB    HB3    sing N N 174 
GLU CG    CD     sing N N 175 
GLU CG    HG2    sing N N 176 
GLU CG    HG3    sing N N 177 
GLU CD    OE1    doub N N 178 
GLU CD    OE2    sing N N 179 
GLU OE2   HE2    sing N N 180 
GLU OXT   HXT    sing N N 181 
GLY N     CA     sing N N 182 
GLY N     H      sing N N 183 
GLY N     H2     sing N N 184 
GLY CA    C      sing N N 185 
GLY CA    HA2    sing N N 186 
GLY CA    HA3    sing N N 187 
GLY C     O      doub N N 188 
GLY C     OXT    sing N N 189 
GLY OXT   HXT    sing N N 190 
HIS N     CA     sing N N 191 
HIS N     H      sing N N 192 
HIS N     H2     sing N N 193 
HIS CA    C      sing N N 194 
HIS CA    CB     sing N N 195 
HIS CA    HA     sing N N 196 
HIS C     O      doub N N 197 
HIS C     OXT    sing N N 198 
HIS CB    CG     sing N N 199 
HIS CB    HB2    sing N N 200 
HIS CB    HB3    sing N N 201 
HIS CG    ND1    sing Y N 202 
HIS CG    CD2    doub Y N 203 
HIS ND1   CE1    doub Y N 204 
HIS ND1   HD1    sing N N 205 
HIS CD2   NE2    sing Y N 206 
HIS CD2   HD2    sing N N 207 
HIS CE1   NE2    sing Y N 208 
HIS CE1   HE1    sing N N 209 
HIS NE2   HE2    sing N N 210 
HIS OXT   HXT    sing N N 211 
ILE N     CA     sing N N 212 
ILE N     H      sing N N 213 
ILE N     H2     sing N N 214 
ILE CA    C      sing N N 215 
ILE CA    CB     sing N N 216 
ILE CA    HA     sing N N 217 
ILE C     O      doub N N 218 
ILE C     OXT    sing N N 219 
ILE CB    CG1    sing N N 220 
ILE CB    CG2    sing N N 221 
ILE CB    HB     sing N N 222 
ILE CG1   CD1    sing N N 223 
ILE CG1   HG12   sing N N 224 
ILE CG1   HG13   sing N N 225 
ILE CG2   HG21   sing N N 226 
ILE CG2   HG22   sing N N 227 
ILE CG2   HG23   sing N N 228 
ILE CD1   HD11   sing N N 229 
ILE CD1   HD12   sing N N 230 
ILE CD1   HD13   sing N N 231 
ILE OXT   HXT    sing N N 232 
KDH O1    C3     sing N N 233 
KDH O1    HO1    sing N N 234 
KDH C3    C6     doub Y N 235 
KDH C3    C4     sing Y N 236 
KDH C6    O7     sing N N 237 
KDH C6    C9     sing Y N 238 
KDH O7    HO7    sing N N 239 
KDH C9    O10    sing N N 240 
KDH C9    C12    doub Y N 241 
KDH O10   HO10   sing N N 242 
KDH C12   C14    sing Y N 243 
KDH C12   H12    sing N N 244 
KDH C14   C15    sing N N 245 
KDH C14   C4     doub Y N 246 
KDH C15   C33    sing N N 247 
KDH C15   O01    sing N N 248 
KDH C15   H15    sing N N 249 
KDH C20   C21    doub Y N 250 
KDH C20   C31    sing Y N 251 
KDH C20   O01    sing N N 252 
KDH C21   C24    sing Y N 253 
KDH C21   H21    sing N N 254 
KDH C24   C26    doub Y N 255 
KDH C24   O02    sing N N 256 
KDH C26   C29    sing Y N 257 
KDH C26   H26    sing N N 258 
KDH C29   C31    doub Y N 259 
KDH C29   O03    sing N N 260 
KDH C31   C01    sing N N 261 
KDH C33   C01    sing N N 262 
KDH C33   O35    sing N N 263 
KDH C33   H33    sing N N 264 
KDH C36   C38    sing N N 265 
KDH C36   O35    sing N N 266 
KDH C36   O37    doub N N 267 
KDH C38   C39    doub Y N 268 
KDH C38   C41    sing Y N 269 
KDH C39   C49    sing Y N 270 
KDH C39   H39    sing N N 271 
KDH C41   C43    doub Y N 272 
KDH C41   H41    sing N N 273 
KDH C01   H01    sing N N 274 
KDH C01   H01A   sing N N 275 
KDH O02   HO02   sing N N 276 
KDH O03   HO03   sing N N 277 
KDH C4    H4     sing N N 278 
KDH C43   O44    sing N N 279 
KDH C43   C46    sing Y N 280 
KDH O44   HO44   sing N N 281 
KDH C46   O47    sing N N 282 
KDH C46   C49    doub Y N 283 
KDH O47   HO47   sing N N 284 
KDH C49   O50    sing N N 285 
KDH O50   HO50   sing N N 286 
LEU N     CA     sing N N 287 
LEU N     H      sing N N 288 
LEU N     H2     sing N N 289 
LEU CA    C      sing N N 290 
LEU CA    CB     sing N N 291 
LEU CA    HA     sing N N 292 
LEU C     O      doub N N 293 
LEU C     OXT    sing N N 294 
LEU CB    CG     sing N N 295 
LEU CB    HB2    sing N N 296 
LEU CB    HB3    sing N N 297 
LEU CG    CD1    sing N N 298 
LEU CG    CD2    sing N N 299 
LEU CG    HG     sing N N 300 
LEU CD1   HD11   sing N N 301 
LEU CD1   HD12   sing N N 302 
LEU CD1   HD13   sing N N 303 
LEU CD2   HD21   sing N N 304 
LEU CD2   HD22   sing N N 305 
LEU CD2   HD23   sing N N 306 
LEU OXT   HXT    sing N N 307 
LYS N     CA     sing N N 308 
LYS N     H      sing N N 309 
LYS N     H2     sing N N 310 
LYS CA    C      sing N N 311 
LYS CA    CB     sing N N 312 
LYS CA    HA     sing N N 313 
LYS C     O      doub N N 314 
LYS C     OXT    sing N N 315 
LYS CB    CG     sing N N 316 
LYS CB    HB2    sing N N 317 
LYS CB    HB3    sing N N 318 
LYS CG    CD     sing N N 319 
LYS CG    HG2    sing N N 320 
LYS CG    HG3    sing N N 321 
LYS CD    CE     sing N N 322 
LYS CD    HD2    sing N N 323 
LYS CD    HD3    sing N N 324 
LYS CE    NZ     sing N N 325 
LYS CE    HE2    sing N N 326 
LYS CE    HE3    sing N N 327 
LYS NZ    HZ1    sing N N 328 
LYS NZ    HZ2    sing N N 329 
LYS NZ    HZ3    sing N N 330 
LYS OXT   HXT    sing N N 331 
MET N     CA     sing N N 332 
MET N     H      sing N N 333 
MET N     H2     sing N N 334 
MET CA    C      sing N N 335 
MET CA    CB     sing N N 336 
MET CA    HA     sing N N 337 
MET C     O      doub N N 338 
MET C     OXT    sing N N 339 
MET CB    CG     sing N N 340 
MET CB    HB2    sing N N 341 
MET CB    HB3    sing N N 342 
MET CG    SD     sing N N 343 
MET CG    HG2    sing N N 344 
MET CG    HG3    sing N N 345 
MET SD    CE     sing N N 346 
MET CE    HE1    sing N N 347 
MET CE    HE2    sing N N 348 
MET CE    HE3    sing N N 349 
MET OXT   HXT    sing N N 350 
PHE N     CA     sing N N 351 
PHE N     H      sing N N 352 
PHE N     H2     sing N N 353 
PHE CA    C      sing N N 354 
PHE CA    CB     sing N N 355 
PHE CA    HA     sing N N 356 
PHE C     O      doub N N 357 
PHE C     OXT    sing N N 358 
PHE CB    CG     sing N N 359 
PHE CB    HB2    sing N N 360 
PHE CB    HB3    sing N N 361 
PHE CG    CD1    doub Y N 362 
PHE CG    CD2    sing Y N 363 
PHE CD1   CE1    sing Y N 364 
PHE CD1   HD1    sing N N 365 
PHE CD2   CE2    doub Y N 366 
PHE CD2   HD2    sing N N 367 
PHE CE1   CZ     doub Y N 368 
PHE CE1   HE1    sing N N 369 
PHE CE2   CZ     sing Y N 370 
PHE CE2   HE2    sing N N 371 
PHE CZ    HZ     sing N N 372 
PHE OXT   HXT    sing N N 373 
PRO N     CA     sing N N 374 
PRO N     CD     sing N N 375 
PRO N     H      sing N N 376 
PRO CA    C      sing N N 377 
PRO CA    CB     sing N N 378 
PRO CA    HA     sing N N 379 
PRO C     O      doub N N 380 
PRO C     OXT    sing N N 381 
PRO CB    CG     sing N N 382 
PRO CB    HB2    sing N N 383 
PRO CB    HB3    sing N N 384 
PRO CG    CD     sing N N 385 
PRO CG    HG2    sing N N 386 
PRO CG    HG3    sing N N 387 
PRO CD    HD2    sing N N 388 
PRO CD    HD3    sing N N 389 
PRO OXT   HXT    sing N N 390 
SER N     CA     sing N N 391 
SER N     H      sing N N 392 
SER N     H2     sing N N 393 
SER CA    C      sing N N 394 
SER CA    CB     sing N N 395 
SER CA    HA     sing N N 396 
SER C     O      doub N N 397 
SER C     OXT    sing N N 398 
SER CB    OG     sing N N 399 
SER CB    HB2    sing N N 400 
SER CB    HB3    sing N N 401 
SER OG    HG     sing N N 402 
SER OXT   HXT    sing N N 403 
THR N     CA     sing N N 404 
THR N     H      sing N N 405 
THR N     H2     sing N N 406 
THR CA    C      sing N N 407 
THR CA    CB     sing N N 408 
THR CA    HA     sing N N 409 
THR C     O      doub N N 410 
THR C     OXT    sing N N 411 
THR CB    OG1    sing N N 412 
THR CB    CG2    sing N N 413 
THR CB    HB     sing N N 414 
THR OG1   HG1    sing N N 415 
THR CG2   HG21   sing N N 416 
THR CG2   HG22   sing N N 417 
THR CG2   HG23   sing N N 418 
THR OXT   HXT    sing N N 419 
TRP N     CA     sing N N 420 
TRP N     H      sing N N 421 
TRP N     H2     sing N N 422 
TRP CA    C      sing N N 423 
TRP CA    CB     sing N N 424 
TRP CA    HA     sing N N 425 
TRP C     O      doub N N 426 
TRP C     OXT    sing N N 427 
TRP CB    CG     sing N N 428 
TRP CB    HB2    sing N N 429 
TRP CB    HB3    sing N N 430 
TRP CG    CD1    doub Y N 431 
TRP CG    CD2    sing Y N 432 
TRP CD1   NE1    sing Y N 433 
TRP CD1   HD1    sing N N 434 
TRP CD2   CE2    doub Y N 435 
TRP CD2   CE3    sing Y N 436 
TRP NE1   CE2    sing Y N 437 
TRP NE1   HE1    sing N N 438 
TRP CE2   CZ2    sing Y N 439 
TRP CE3   CZ3    doub Y N 440 
TRP CE3   HE3    sing N N 441 
TRP CZ2   CH2    doub Y N 442 
TRP CZ2   HZ2    sing N N 443 
TRP CZ3   CH2    sing Y N 444 
TRP CZ3   HZ3    sing N N 445 
TRP CH2   HH2    sing N N 446 
TRP OXT   HXT    sing N N 447 
TYR N     CA     sing N N 448 
TYR N     H      sing N N 449 
TYR N     H2     sing N N 450 
TYR CA    C      sing N N 451 
TYR CA    CB     sing N N 452 
TYR CA    HA     sing N N 453 
TYR C     O      doub N N 454 
TYR C     OXT    sing N N 455 
TYR CB    CG     sing N N 456 
TYR CB    HB2    sing N N 457 
TYR CB    HB3    sing N N 458 
TYR CG    CD1    doub Y N 459 
TYR CG    CD2    sing Y N 460 
TYR CD1   CE1    sing Y N 461 
TYR CD1   HD1    sing N N 462 
TYR CD2   CE2    doub Y N 463 
TYR CD2   HD2    sing N N 464 
TYR CE1   CZ     doub Y N 465 
TYR CE1   HE1    sing N N 466 
TYR CE2   CZ     sing Y N 467 
TYR CE2   HE2    sing N N 468 
TYR CZ    OH     sing N N 469 
TYR OH    HH     sing N N 470 
TYR OXT   HXT    sing N N 471 
VAL N     CA     sing N N 472 
VAL N     H      sing N N 473 
VAL N     H2     sing N N 474 
VAL CA    C      sing N N 475 
VAL CA    CB     sing N N 476 
VAL CA    HA     sing N N 477 
VAL C     O      doub N N 478 
VAL C     OXT    sing N N 479 
VAL CB    CG1    sing N N 480 
VAL CB    CG2    sing N N 481 
VAL CB    HB     sing N N 482 
VAL CG1   HG11   sing N N 483 
VAL CG1   HG12   sing N N 484 
VAL CG1   HG13   sing N N 485 
VAL CG2   HG21   sing N N 486 
VAL CG2   HG22   sing N N 487 
VAL CG2   HG23   sing N N 488 
VAL OXT   HXT    sing N N 489 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           22277115 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3ZG6 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8ZVP 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010965 
_atom_sites.fract_transf_matrix[1][2]   0.006331 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012661 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006958 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N     . PRO A 1 1   ? -32.731 -31.976 -8.816  1.00 84.21  ? 10  PRO A N     1 
ATOM   2    C  CA    . PRO A 1 1   ? -32.024 -32.838 -9.764  1.00 86.73  ? 10  PRO A CA    1 
ATOM   3    C  C     . PRO A 1 1   ? -32.865 -33.065 -11.027 1.00 85.84  ? 10  PRO A C     1 
ATOM   4    O  O     . PRO A 1 1   ? -32.484 -32.651 -12.104 1.00 88.54  ? 10  PRO A O     1 
ATOM   5    C  CB    . PRO A 1 1   ? -31.834 -34.151 -8.985  1.00 81.58  ? 10  PRO A CB    1 
ATOM   6    C  CG    . PRO A 1 1   ? -32.909 -34.136 -7.885  1.00 82.74  ? 10  PRO A CG    1 
ATOM   7    C  CD    . PRO A 1 1   ? -33.424 -32.712 -7.761  1.00 82.37  ? 10  PRO A CD    1 
ATOM   8    N  N     . PHE A 1 2   ? -34.003 -33.722 -10.830 1.00 86.31  ? 11  PHE A N     1 
ATOM   9    C  CA    . PHE A 1 2   ? -35.013 -34.087 -11.849 1.00 75.79  ? 11  PHE A CA    1 
ATOM   10   C  C     . PHE A 1 2   ? -36.307 -33.306 -11.565 1.00 74.76  ? 11  PHE A C     1 
ATOM   11   O  O     . PHE A 1 2   ? -36.922 -32.782 -12.512 1.00 76.16  ? 11  PHE A O     1 
ATOM   12   C  CB    . PHE A 1 2   ? -35.201 -35.606 -11.789 1.00 70.64  ? 11  PHE A CB    1 
ATOM   13   C  CG    . PHE A 1 2   ? -36.264 -36.112 -12.721 1.00 58.62  ? 11  PHE A CG    1 
ATOM   14   C  CD1   . PHE A 1 2   ? -37.590 -36.134 -12.330 1.00 59.56  ? 11  PHE A CD1   1 
ATOM   15   C  CD2   . PHE A 1 2   ? -35.948 -36.474 -14.020 1.00 57.32  ? 11  PHE A CD2   1 
ATOM   16   C  CE1   . PHE A 1 2   ? -38.576 -36.554 -13.214 1.00 59.75  ? 11  PHE A CE1   1 
ATOM   17   C  CE2   . PHE A 1 2   ? -36.936 -36.899 -14.899 1.00 60.50  ? 11  PHE A CE2   1 
ATOM   18   C  CZ    . PHE A 1 2   ? -38.248 -36.930 -14.495 1.00 54.94  ? 11  PHE A CZ    1 
ATOM   19   N  N     . THR A 1 3   ? -36.673 -33.230 -10.278 1.00 73.60  ? 12  THR A N     1 
ATOM   20   C  CA    . THR A 1 3   ? -37.930 -32.661 -9.716  1.00 83.82  ? 12  THR A CA    1 
ATOM   21   C  C     . THR A 1 3   ? -37.713 -31.183 -9.342  1.00 91.21  ? 12  THR A C     1 
ATOM   22   O  O     . THR A 1 3   ? -38.710 -30.516 -8.997  1.00 89.98  ? 12  THR A O     1 
ATOM   23   C  CB    . THR A 1 3   ? -38.404 -33.526 -8.531  1.00 91.71  ? 12  THR A CB    1 
ATOM   24   O  OG1   . THR A 1 3   ? -39.706 -33.127 -8.098  1.00 87.98  ? 12  THR A OG1   1 
ATOM   25   C  CG2   . THR A 1 3   ? -37.473 -33.482 -7.337  1.00 89.18  ? 12  THR A CG2   1 
ATOM   26   N  N     . ALA A 1 4   ? -36.461 -30.697 -9.411  1.00 87.08  ? 13  ALA A N     1 
ATOM   27   C  CA    . ALA A 1 4   ? -36.032 -29.328 -9.032  1.00 76.08  ? 13  ALA A CA    1 
ATOM   28   C  C     . ALA A 1 4   ? -36.914 -28.272 -9.701  1.00 70.93  ? 13  ALA A C     1 
ATOM   29   O  O     . ALA A 1 4   ? -37.329 -28.488 -10.849 1.00 64.15  ? 13  ALA A O     1 
ATOM   30   C  CB    . ALA A 1 4   ? -34.594 -29.091 -9.421  1.00 70.67  ? 13  ALA A CB    1 
ATOM   31   N  N     . ASP A 1 5   ? -37.060 -27.136 -9.020  1.00 66.06  ? 14  ASP A N     1 
ATOM   32   C  CA    . ASP A 1 5   ? -37.852 -25.938 -9.419  1.00 73.08  ? 14  ASP A CA    1 
ATOM   33   C  C     . ASP A 1 5   ? -37.032 -25.118 -10.436 1.00 67.47  ? 14  ASP A C     1 
ATOM   34   O  O     . ASP A 1 5   ? -36.023 -24.489 -10.026 1.00 65.02  ? 14  ASP A O     1 
ATOM   35   C  CB    . ASP A 1 5   ? -38.196 -25.156 -8.142  1.00 79.61  ? 14  ASP A CB    1 
ATOM   36   C  CG    . ASP A 1 5   ? -39.536 -24.443 -8.142  1.00 88.03  ? 14  ASP A CG    1 
ATOM   37   O  OD1   . ASP A 1 5   ? -39.793 -23.657 -9.097  1.00 86.88  ? 14  ASP A OD1   1 
ATOM   38   O  OD2   . ASP A 1 5   ? -40.302 -24.660 -7.161  1.00 74.90  ? 14  ASP A OD2   1 
ATOM   39   N  N     . LYS A 1 6   ? -37.402 -25.141 -11.719 1.00 56.79  ? 15  LYS A N     1 
ATOM   40   C  CA    . LYS A 1 6   ? -36.599 -24.541 -12.824 1.00 52.46  ? 15  LYS A CA    1 
ATOM   41   C  C     . LYS A 1 6   ? -37.189 -23.184 -13.256 1.00 51.96  ? 15  LYS A C     1 
ATOM   42   O  O     . LYS A 1 6   ? -36.636 -22.566 -14.215 1.00 60.89  ? 15  LYS A O     1 
ATOM   43   C  CB    . LYS A 1 6   ? -36.480 -25.537 -13.986 1.00 54.81  ? 15  LYS A CB    1 
ATOM   44   C  CG    . LYS A 1 6   ? -35.334 -26.535 -13.848 1.00 60.37  ? 15  LYS A CG    1 
ATOM   45   C  CD    . LYS A 1 6   ? -35.435 -27.776 -14.741 1.00 59.84  ? 15  LYS A CD    1 
ATOM   46   C  CE    . LYS A 1 6   ? -34.525 -28.901 -14.291 1.00 62.12  ? 15  LYS A CE    1 
ATOM   47   N  NZ    . LYS A 1 6   ? -34.096 -29.765 -15.417 1.00 75.82  ? 15  LYS A NZ    1 
ATOM   48   N  N     . GLY A 1 7   ? -38.251 -22.725 -12.589 1.00 51.39  ? 16  GLY A N     1 
ATOM   49   C  CA    . GLY A 1 7   ? -38.868 -21.393 -12.778 1.00 50.65  ? 16  GLY A CA    1 
ATOM   50   C  C     . GLY A 1 7   ? -39.658 -21.267 -14.081 1.00 52.66  ? 16  GLY A C     1 
ATOM   51   O  O     . GLY A 1 7   ? -39.881 -22.264 -14.786 1.00 46.31  ? 16  GLY A O     1 
ATOM   52   N  N     . LYS A 1 8   ? -40.077 -20.049 -14.396 1.00 51.98  ? 17  LYS A N     1 
ATOM   53   C  CA    . LYS A 1 8   ? -40.904 -19.746 -15.583 1.00 50.86  ? 17  LYS A CA    1 
ATOM   54   C  C     . LYS A 1 8   ? -39.968 -19.670 -16.787 1.00 46.52  ? 17  LYS A C     1 
ATOM   55   O  O     . LYS A 1 8   ? -39.088 -18.839 -16.759 1.00 42.99  ? 17  LYS A O     1 
ATOM   56   C  CB    . LYS A 1 8   ? -41.664 -18.432 -15.382 1.00 52.45  ? 17  LYS A CB    1 
ATOM   57   C  CG    . LYS A 1 8   ? -42.882 -18.523 -14.478 1.00 55.94  ? 17  LYS A CG    1 
ATOM   58   C  CD    . LYS A 1 8   ? -44.186 -18.408 -15.242 1.00 67.98  ? 17  LYS A CD    1 
ATOM   59   C  CE    . LYS A 1 8   ? -45.395 -18.302 -14.335 1.00 73.69  ? 17  LYS A CE    1 
ATOM   60   N  NZ    . LYS A 1 8   ? -45.877 -19.637 -13.898 1.00 73.20  ? 17  LYS A NZ    1 
ATOM   61   N  N     . CYS A 1 9   ? -40.222 -20.483 -17.805 1.00 41.99  ? 18  CYS A N     1 
ATOM   62   C  CA    . CYS A 1 9   ? -39.382 -20.686 -19.000 1.00 46.90  ? 18  CYS A CA    1 
ATOM   63   C  C     . CYS A 1 9   ? -40.168 -20.250 -20.220 1.00 44.11  ? 18  CYS A C     1 
ATOM   64   O  O     . CYS A 1 9   ? -41.376 -20.452 -20.223 1.00 55.19  ? 18  CYS A O     1 
ATOM   65   C  CB    . CYS A 1 9   ? -39.025 -22.155 -19.157 1.00 49.45  ? 18  CYS A CB    1 
ATOM   66   S  SG    . CYS A 1 9   ? -37.921 -22.747 -17.854 1.00 47.76  ? 18  CYS A SG    1 
ATOM   67   N  N     . GLY A 1 10  ? -39.477 -19.698 -21.208 1.00 48.05  ? 19  GLY A N     1 
ATOM   68   C  CA    . GLY A 1 10  ? -39.986 -19.432 -22.573 1.00 42.75  ? 19  GLY A CA    1 
ATOM   69   C  C     . GLY A 1 10  ? -40.978 -18.289 -22.651 1.00 40.38  ? 19  GLY A C     1 
ATOM   70   O  O     . GLY A 1 10  ? -41.675 -18.218 -23.676 1.00 42.34  ? 19  GLY A O     1 
ATOM   71   N  N     . LEU A 1 11  ? -41.034 -17.397 -21.651 1.00 45.31  ? 20  LEU A N     1 
ATOM   72   C  CA    . LEU A 1 11  ? -41.867 -16.160 -21.689 1.00 41.25  ? 20  LEU A CA    1 
ATOM   73   C  C     . LEU A 1 11  ? -41.656 -15.484 -23.035 1.00 46.83  ? 20  LEU A C     1 
ATOM   74   O  O     . LEU A 1 11  ? -40.576 -15.630 -23.618 1.00 45.44  ? 20  LEU A O     1 
ATOM   75   C  CB    . LEU A 1 11  ? -41.447 -15.244 -20.536 1.00 48.59  ? 20  LEU A CB    1 
ATOM   76   C  CG    . LEU A 1 11  ? -42.295 -15.317 -19.265 1.00 51.58  ? 20  LEU A CG    1 
ATOM   77   C  CD1   . LEU A 1 11  ? -42.602 -16.737 -18.880 1.00 51.81  ? 20  LEU A CD1   1 
ATOM   78   C  CD2   . LEU A 1 11  ? -41.621 -14.605 -18.109 1.00 49.03  ? 20  LEU A CD2   1 
ATOM   79   N  N     . PRO A 1 12  ? -42.619 -14.674 -23.555 1.00 54.25  ? 21  PRO A N     1 
ATOM   80   C  CA    . PRO A 1 12  ? -42.422 -13.970 -24.816 1.00 47.59  ? 21  PRO A CA    1 
ATOM   81   C  C     . PRO A 1 12  ? -41.353 -12.887 -24.630 1.00 50.53  ? 21  PRO A C     1 
ATOM   82   O  O     . PRO A 1 12  ? -41.090 -12.430 -23.508 1.00 43.63  ? 21  PRO A O     1 
ATOM   83   C  CB    . PRO A 1 12  ? -43.775 -13.324 -25.154 1.00 47.30  ? 21  PRO A CB    1 
ATOM   84   C  CG    . PRO A 1 12  ? -44.724 -13.854 -24.117 1.00 44.56  ? 21  PRO A CG    1 
ATOM   85   C  CD    . PRO A 1 12  ? -43.887 -14.262 -22.930 1.00 48.62  ? 21  PRO A CD    1 
ATOM   86   N  N     . GLU A 1 13  ? -40.762 -12.493 -25.750 1.00 50.26  ? 22  GLU A N     1 
ATOM   87   C  CA    . GLU A 1 13  ? -39.741 -11.433 -25.799 1.00 49.23  ? 22  GLU A CA    1 
ATOM   88   C  C     . GLU A 1 13  ? -40.470 -10.111 -26.052 1.00 47.25  ? 22  GLU A C     1 
ATOM   89   O  O     . GLU A 1 13  ? -41.545 -10.155 -26.642 1.00 52.06  ? 22  GLU A O     1 
ATOM   90   C  CB    . GLU A 1 13  ? -38.727 -11.769 -26.884 1.00 56.22  ? 22  GLU A CB    1 
ATOM   91   C  CG    . GLU A 1 13  ? -37.836 -12.961 -26.551 1.00 56.42  ? 22  GLU A CG    1 
ATOM   92   C  CD    . GLU A 1 13  ? -36.796 -13.245 -27.619 1.00 47.10  ? 22  GLU A CD    1 
ATOM   93   O  OE1   . GLU A 1 13  ? -37.168 -13.335 -28.788 1.00 51.42  ? 22  GLU A OE1   1 
ATOM   94   O  OE2   . GLU A 1 13  ? -35.616 -13.369 -27.274 1.00 61.12  ? 22  GLU A OE2   1 
ATOM   95   N  N     . ILE A 1 14  ? -39.899 -9.007  -25.571 1.00 46.63  ? 23  ILE A N     1 
ATOM   96   C  CA    . ILE A 1 14  ? -40.354 -7.607  -25.785 1.00 51.29  ? 23  ILE A CA    1 
ATOM   97   C  C     . ILE A 1 14  ? -39.271 -6.840  -26.559 1.00 48.86  ? 23  ILE A C     1 
ATOM   98   O  O     . ILE A 1 14  ? -38.105 -7.048  -26.328 1.00 49.91  ? 23  ILE A O     1 
ATOM   99   C  CB    . ILE A 1 14  ? -40.683 -6.951  -24.430 1.00 55.76  ? 23  ILE A CB    1 
ATOM   100  C  CG1   . ILE A 1 14  ? -41.479 -7.891  -23.516 1.00 55.19  ? 23  ILE A CG1   1 
ATOM   101  C  CG2   . ILE A 1 14  ? -41.437 -5.654  -24.648 1.00 61.81  ? 23  ILE A CG2   1 
ATOM   102  C  CD1   . ILE A 1 14  ? -41.373 -7.570  -22.039 1.00 52.64  ? 23  ILE A CD1   1 
ATOM   103  N  N     . PHE A 1 15  ? -39.656 -5.986  -27.488 1.00 53.62  ? 24  PHE A N     1 
ATOM   104  C  CA    . PHE A 1 15  ? -38.703 -5.163  -28.265 1.00 54.47  ? 24  PHE A CA    1 
ATOM   105  C  C     . PHE A 1 15  ? -39.147 -3.710  -28.179 1.00 53.51  ? 24  PHE A C     1 
ATOM   106  O  O     . PHE A 1 15  ? -40.112 -3.355  -28.879 1.00 54.57  ? 24  PHE A O     1 
ATOM   107  C  CB    . PHE A 1 15  ? -38.627 -5.657  -29.708 1.00 53.84  ? 24  PHE A CB    1 
ATOM   108  C  CG    . PHE A 1 15  ? -37.979 -7.009  -29.842 1.00 51.81  ? 24  PHE A CG    1 
ATOM   109  C  CD1   . PHE A 1 15  ? -36.601 -7.144  -29.764 1.00 54.70  ? 24  PHE A CD1   1 
ATOM   110  C  CD2   . PHE A 1 15  ? -38.747 -8.152  -30.002 1.00 55.89  ? 24  PHE A CD2   1 
ATOM   111  C  CE1   . PHE A 1 15  ? -36.001 -8.395  -29.872 1.00 53.57  ? 24  PHE A CE1   1 
ATOM   112  C  CE2   . PHE A 1 15  ? -38.147 -9.401  -30.091 1.00 56.65  ? 24  PHE A CE2   1 
ATOM   113  C  CZ    . PHE A 1 15  ? -36.776 -9.518  -30.024 1.00 52.49  ? 24  PHE A CZ    1 
ATOM   114  N  N     . ASP A 1 16  ? -38.475 -2.925  -27.333 1.00 50.37  ? 25  ASP A N     1 
ATOM   115  C  CA    . ASP A 1 16  ? -38.637 -1.451  -27.280 1.00 53.86  ? 25  ASP A CA    1 
ATOM   116  C  C     . ASP A 1 16  ? -38.395 -0.910  -28.682 1.00 54.37  ? 25  ASP A C     1 
ATOM   117  O  O     . ASP A 1 16  ? -37.450 -1.304  -29.347 1.00 56.01  ? 25  ASP A O     1 
ATOM   118  C  CB    . ASP A 1 16  ? -37.739 -0.822  -26.214 1.00 53.34  ? 25  ASP A CB    1 
ATOM   119  C  CG    . ASP A 1 16  ? -38.191 -1.174  -24.801 1.00 55.97  ? 25  ASP A CG    1 
ATOM   120  O  OD1   . ASP A 1 16  ? -39.358 -1.566  -24.656 1.00 54.36  ? 25  ASP A OD1   1 
ATOM   121  O  OD2   . ASP A 1 16  ? -37.361 -1.095  -23.856 1.00 52.77  ? 25  ASP A OD2   1 
ATOM   122  N  N     . PRO A 1 17  ? -39.272 -0.028  -29.200 1.00 59.04  ? 26  PRO A N     1 
ATOM   123  C  CA    . PRO A 1 17  ? -39.101 0.494   -30.549 1.00 56.05  ? 26  PRO A CA    1 
ATOM   124  C  C     . PRO A 1 17  ? -37.890 1.419   -30.545 1.00 57.93  ? 26  PRO A C     1 
ATOM   125  O  O     . PRO A 1 17  ? -37.531 1.930   -29.487 1.00 49.61  ? 26  PRO A O     1 
ATOM   126  C  CB    . PRO A 1 17  ? -40.431 1.197   -30.857 1.00 59.43  ? 26  PRO A CB    1 
ATOM   127  C  CG    . PRO A 1 17  ? -41.024 1.527   -29.493 1.00 61.20  ? 26  PRO A CG    1 
ATOM   128  C  CD    . PRO A 1 17  ? -40.476 0.492   -28.529 1.00 62.47  ? 26  PRO A CD    1 
ATOM   129  N  N     . PRO A 1 18  ? -37.240 1.624   -31.719 1.00 51.32  ? 27  PRO A N     1 
ATOM   130  C  CA    . PRO A 1 18  ? -36.000 2.388   -31.829 1.00 53.88  ? 27  PRO A CA    1 
ATOM   131  C  C     . PRO A 1 18  ? -35.982 3.703   -31.037 1.00 53.15  ? 27  PRO A C     1 
ATOM   132  O  O     . PRO A 1 18  ? -35.058 3.897   -30.314 1.00 58.56  ? 27  PRO A O     1 
ATOM   133  C  CB    . PRO A 1 18  ? -35.910 2.707   -33.335 1.00 55.10  ? 27  PRO A CB    1 
ATOM   134  C  CG    . PRO A 1 18  ? -36.630 1.565   -34.014 1.00 56.78  ? 27  PRO A CG    1 
ATOM   135  C  CD    . PRO A 1 18  ? -37.697 1.124   -33.026 1.00 56.98  ? 27  PRO A CD    1 
ATOM   136  N  N     . GLU A 1 19  ? -37.016 4.534   -31.184 1.00 58.63  ? 28  GLU A N     1 
ATOM   137  C  CA    . GLU A 1 19  ? -37.172 5.843   -30.490 1.00 67.89  ? 28  GLU A CA    1 
ATOM   138  C  C     . GLU A 1 19  ? -36.973 5.621   -28.987 1.00 64.97  ? 28  GLU A C     1 
ATOM   139  O  O     . GLU A 1 19  ? -35.950 6.066   -28.451 1.00 58.61  ? 28  GLU A O     1 
ATOM   140  C  CB    . GLU A 1 19  ? -38.556 6.451   -30.766 1.00 74.09  ? 28  GLU A CB    1 
ATOM   141  C  CG    . GLU A 1 19  ? -38.821 6.745   -32.244 1.00 81.76  ? 28  GLU A CG    1 
ATOM   142  C  CD    . GLU A 1 19  ? -39.353 8.134   -32.599 1.00 81.24  ? 28  GLU A CD    1 
ATOM   143  O  OE1   . GLU A 1 19  ? -40.379 8.562   -32.019 1.00 78.51  ? 28  GLU A OE1   1 
ATOM   144  O  OE2   . GLU A 1 19  ? -38.745 8.787   -33.473 1.00 76.19  ? 28  GLU A OE2   1 
ATOM   145  N  N     . GLU A 1 20  ? -37.903 4.886   -28.378 1.00 59.59  ? 29  GLU A N     1 
ATOM   146  C  CA    . GLU A 1 20  ? -37.991 4.623   -26.919 1.00 63.51  ? 29  GLU A CA    1 
ATOM   147  C  C     . GLU A 1 20  ? -36.682 3.959   -26.470 1.00 63.64  ? 29  GLU A C     1 
ATOM   148  O  O     . GLU A 1 20  ? -36.237 4.224   -25.340 1.00 60.27  ? 29  GLU A O     1 
ATOM   149  C  CB    . GLU A 1 20  ? -39.254 3.791   -26.654 1.00 61.18  ? 29  GLU A CB    1 
ATOM   150  C  CG    . GLU A 1 20  ? -39.528 3.462   -25.201 1.00 65.53  ? 29  GLU A CG    1 
ATOM   151  C  CD    . GLU A 1 20  ? -40.736 2.563   -24.978 1.00 73.25  ? 29  GLU A CD    1 
ATOM   152  O  OE1   . GLU A 1 20  ? -41.423 2.236   -25.975 1.00 74.25  ? 29  GLU A OE1   1 
ATOM   153  O  OE2   . GLU A 1 20  ? -40.986 2.179   -23.807 1.00 75.16  ? 29  GLU A OE2   1 
ATOM   154  N  N     . LEU A 1 21  ? -36.036 3.214   -27.362 1.00 61.20  ? 30  LEU A N     1 
ATOM   155  C  CA    . LEU A 1 21  ? -34.746 2.544   -27.063 1.00 65.20  ? 30  LEU A CA    1 
ATOM   156  C  C     . LEU A 1 21  ? -33.606 3.565   -26.884 1.00 64.06  ? 30  LEU A C     1 
ATOM   157  O  O     . LEU A 1 21  ? -32.974 3.541   -25.801 1.00 53.80  ? 30  LEU A O     1 
ATOM   158  C  CB    . LEU A 1 21  ? -34.436 1.536   -28.169 1.00 63.80  ? 30  LEU A CB    1 
ATOM   159  C  CG    . LEU A 1 21  ? -33.357 0.525   -27.797 1.00 66.01  ? 30  LEU A CG    1 
ATOM   160  C  CD1   . LEU A 1 21  ? -33.509 0.079   -26.345 1.00 69.71  ? 30  LEU A CD1   1 
ATOM   161  C  CD2   . LEU A 1 21  ? -33.387 -0.668  -28.735 1.00 64.51  ? 30  LEU A CD2   1 
ATOM   162  N  N     . GLU A 1 22  ? -33.347 4.440   -27.866 1.00 57.40  ? 31  GLU A N     1 
ATOM   163  C  CA    . GLU A 1 22  ? -32.288 5.489   -27.735 1.00 60.32  ? 31  GLU A CA    1 
ATOM   164  C  C     . GLU A 1 22  ? -32.534 6.350   -26.471 1.00 52.97  ? 31  GLU A C     1 
ATOM   165  O  O     . GLU A 1 22  ? -31.597 6.561   -25.701 1.00 55.10  ? 31  GLU A O     1 
ATOM   166  C  CB    . GLU A 1 22  ? -32.132 6.313   -29.027 1.00 61.38  ? 31  GLU A CB    1 
ATOM   167  C  CG    . GLU A 1 22  ? -30.921 5.912   -29.889 1.00 71.23  ? 31  GLU A CG    1 
ATOM   168  C  CD    . GLU A 1 22  ? -29.528 5.986   -29.243 1.00 80.09  ? 31  GLU A CD    1 
ATOM   169  O  OE1   . GLU A 1 22  ? -28.510 5.930   -29.995 1.00 63.85  ? 31  GLU A OE1   1 
ATOM   170  O  OE2   . GLU A 1 22  ? -29.440 6.085   -27.974 1.00 82.18  ? 31  GLU A OE2   1 
ATOM   171  N  N     . ARG A 1 23  ? -33.756 6.811   -26.214 1.00 54.79  ? 32  ARG A N     1 
ATOM   172  C  CA    . ARG A 1 23  ? -34.067 7.631   -25.012 1.00 57.29  ? 32  ARG A CA    1 
ATOM   173  C  C     . ARG A 1 23  ? -33.700 6.851   -23.742 1.00 49.44  ? 32  ARG A C     1 
ATOM   174  O  O     . ARG A 1 23  ? -33.249 7.467   -22.798 1.00 56.91  ? 32  ARG A O     1 
ATOM   175  C  CB    . ARG A 1 23  ? -35.537 8.056   -25.050 1.00 67.23  ? 32  ARG A CB    1 
ATOM   176  C  CG    . ARG A 1 23  ? -36.000 8.895   -23.865 1.00 78.90  ? 32  ARG A CG    1 
ATOM   177  C  CD    . ARG A 1 23  ? -37.388 9.518   -24.057 1.00 90.70  ? 32  ARG A CD    1 
ATOM   178  N  NE    . ARG A 1 23  ? -38.252 8.843   -25.034 1.00 94.15  ? 32  ARG A NE    1 
ATOM   179  C  CZ    . ARG A 1 23  ? -39.035 7.781   -24.793 1.00 96.69  ? 32  ARG A CZ    1 
ATOM   180  N  NH1   . ARG A 1 23  ? -39.098 7.235   -23.586 1.00 85.38  ? 32  ARG A NH1   1 
ATOM   181  N  NH2   . ARG A 1 23  ? -39.754 7.267   -25.780 1.00 90.29  ? 32  ARG A NH2   1 
ATOM   182  N  N     . LYS A 1 24  ? -33.838 5.529   -23.729 1.00 54.49  ? 33  LYS A N     1 
ATOM   183  C  CA    . LYS A 1 24  ? -33.588 4.705   -22.517 1.00 50.40  ? 33  LYS A CA    1 
ATOM   184  C  C     . LYS A 1 24  ? -32.088 4.511   -22.339 1.00 44.04  ? 33  LYS A C     1 
ATOM   185  O  O     . LYS A 1 24  ? -31.631 4.465   -21.198 1.00 49.66  ? 33  LYS A O     1 
ATOM   186  C  CB    . LYS A 1 24  ? -34.299 3.351   -22.576 1.00 46.79  ? 33  LYS A CB    1 
ATOM   187  C  CG    . LYS A 1 24  ? -35.784 3.376   -22.255 1.00 43.48  ? 33  LYS A CG    1 
ATOM   188  C  CD    . LYS A 1 24  ? -36.446 1.993   -22.291 1.00 44.67  ? 33  LYS A CD    1 
ATOM   189  C  CE    . LYS A 1 24  ? -37.891 2.002   -21.827 1.00 44.92  ? 33  LYS A CE    1 
ATOM   190  N  NZ    . LYS A 1 24  ? -38.481 0.637   -21.773 1.00 47.17  ? 33  LYS A NZ    1 
ATOM   191  N  N     . VAL A 1 25  ? -31.339 4.409   -23.418 1.00 50.75  ? 34  VAL A N     1 
ATOM   192  C  CA    . VAL A 1 25  ? -29.877 4.150   -23.311 1.00 50.64  ? 34  VAL A CA    1 
ATOM   193  C  C     . VAL A 1 25  ? -29.218 5.463   -22.893 1.00 54.52  ? 34  VAL A C     1 
ATOM   194  O  O     . VAL A 1 25  ? -28.245 5.399   -22.093 1.00 46.18  ? 34  VAL A O     1 
ATOM   195  C  CB    . VAL A 1 25  ? -29.301 3.547   -24.610 1.00 52.51  ? 34  VAL A CB    1 
ATOM   196  C  CG1   . VAL A 1 25  ? -27.785 3.404   -24.544 1.00 55.83  ? 34  VAL A CG1   1 
ATOM   197  C  CG2   . VAL A 1 25  ? -29.932 2.187   -24.908 1.00 48.10  ? 34  VAL A CG2   1 
ATOM   198  N  N     . TRP A 1 26  ? -29.762 6.598   -23.369 1.00 55.24  ? 35  TRP A N     1 
ATOM   199  C  CA    . TRP A 1 26  ? -29.337 7.957   -22.936 1.00 58.91  ? 35  TRP A CA    1 
ATOM   200  C  C     . TRP A 1 26  ? -29.624 8.112   -21.442 1.00 52.71  ? 35  TRP A C     1 
ATOM   201  O  O     . TRP A 1 26  ? -28.788 8.671   -20.751 1.00 63.40  ? 35  TRP A O     1 
ATOM   202  C  CB    . TRP A 1 26  ? -29.983 9.077   -23.764 1.00 63.47  ? 35  TRP A CB    1 
ATOM   203  C  CG    . TRP A 1 26  ? -29.119 9.566   -24.896 1.00 68.04  ? 35  TRP A CG    1 
ATOM   204  C  CD1   . TRP A 1 26  ? -29.395 9.492   -26.234 1.00 63.08  ? 35  TRP A CD1   1 
ATOM   205  C  CD2   . TRP A 1 26  ? -27.840 10.225  -24.788 1.00 58.68  ? 35  TRP A CD2   1 
ATOM   206  N  NE1   . TRP A 1 26  ? -28.370 10.037  -26.958 1.00 65.22  ? 35  TRP A NE1   1 
ATOM   207  C  CE2   . TRP A 1 26  ? -27.406 10.501  -26.104 1.00 62.78  ? 35  TRP A CE2   1 
ATOM   208  C  CE3   . TRP A 1 26  ? -27.007 10.582  -23.716 1.00 60.59  ? 35  TRP A CE3   1 
ATOM   209  C  CZ2   . TRP A 1 26  ? -26.185 11.128  -26.374 1.00 66.88  ? 35  TRP A CZ2   1 
ATOM   210  C  CZ3   . TRP A 1 26  ? -25.799 11.196  -23.981 1.00 60.21  ? 35  TRP A CZ3   1 
ATOM   211  C  CH2   . TRP A 1 26  ? -25.395 11.461  -25.295 1.00 62.86  ? 35  TRP A CH2   1 
ATOM   212  N  N     . GLU A 1 27  ? -30.738 7.571   -20.962 1.00 50.55  ? 36  GLU A N     1 
ATOM   213  C  CA    . GLU A 1 27  ? -31.167 7.691   -19.541 1.00 51.14  ? 36  GLU A CA    1 
ATOM   214  C  C     . GLU A 1 27  ? -30.209 6.869   -18.662 1.00 50.28  ? 36  GLU A C     1 
ATOM   215  O  O     . GLU A 1 27  ? -29.814 7.357   -17.572 1.00 48.66  ? 36  GLU A O     1 
ATOM   216  C  CB    . GLU A 1 27  ? -32.648 7.315   -19.461 1.00 50.03  ? 36  GLU A CB    1 
ATOM   217  C  CG    . GLU A 1 27  ? -33.173 7.179   -18.054 1.00 55.78  ? 36  GLU A CG    1 
ATOM   218  C  CD    . GLU A 1 27  ? -32.952 8.402   -17.185 1.00 67.63  ? 36  GLU A CD    1 
ATOM   219  O  OE1   . GLU A 1 27  ? -33.364 9.516   -17.620 1.00 66.07  ? 36  GLU A OE1   1 
ATOM   220  O  OE2   . GLU A 1 27  ? -32.349 8.242   -16.090 1.00 65.24  ? 36  GLU A OE2   1 
ATOM   221  N  N     . LEU A 1 28  ? -29.784 5.695   -19.149 1.00 50.57  ? 37  LEU A N     1 
ATOM   222  C  CA    . LEU A 1 28  ? -28.812 4.809   -18.447 1.00 49.06  ? 37  LEU A CA    1 
ATOM   223  C  C     . LEU A 1 28  ? -27.460 5.521   -18.318 1.00 54.52  ? 37  LEU A C     1 
ATOM   224  O  O     . LEU A 1 28  ? -26.900 5.494   -17.189 1.00 42.11  ? 37  LEU A O     1 
ATOM   225  C  CB    . LEU A 1 28  ? -28.665 3.496   -19.219 1.00 46.24  ? 37  LEU A CB    1 
ATOM   226  C  CG    . LEU A 1 28  ? -27.614 2.515   -18.689 1.00 45.65  ? 37  LEU A CG    1 
ATOM   227  C  CD1   . LEU A 1 28  ? -27.859 2.180   -17.226 1.00 43.82  ? 37  LEU A CD1   1 
ATOM   228  C  CD2   . LEU A 1 28  ? -27.589 1.241   -19.529 1.00 43.26  ? 37  LEU A CD2   1 
ATOM   229  N  N     . ALA A 1 29  ? -26.960 6.106   -19.427 1.00 45.75  ? 38  ALA A N     1 
ATOM   230  C  CA    . ALA A 1 29  ? -25.720 6.904   -19.462 1.00 43.41  ? 38  ALA A CA    1 
ATOM   231  C  C     . ALA A 1 29  ? -25.788 7.938   -18.333 1.00 46.58  ? 38  ALA A C     1 
ATOM   232  O  O     . ALA A 1 29  ? -24.836 8.028   -17.532 1.00 45.39  ? 38  ALA A O     1 
ATOM   233  C  CB    . ALA A 1 29  ? -25.559 7.562   -20.820 1.00 47.01  ? 38  ALA A CB    1 
ATOM   234  N  N     . ARG A 1 30  ? -26.912 8.657   -18.246 1.00 47.38  ? 39  ARG A N     1 
ATOM   235  C  CA    . ARG A 1 30  ? -27.153 9.670   -17.190 1.00 46.96  ? 39  ARG A CA    1 
ATOM   236  C  C     . ARG A 1 30  ? -27.030 9.013   -15.816 1.00 46.08  ? 39  ARG A C     1 
ATOM   237  O  O     . ARG A 1 30  ? -26.322 9.568   -14.976 1.00 47.68  ? 39  ARG A O     1 
ATOM   238  C  CB    . ARG A 1 30  ? -28.472 10.399  -17.425 1.00 51.38  ? 39  ARG A CB    1 
ATOM   239  C  CG    . ARG A 1 30  ? -28.726 11.477  -16.389 1.00 57.91  ? 39  ARG A CG    1 
ATOM   240  C  CD    . ARG A 1 30  ? -29.794 12.500  -16.724 1.00 61.78  ? 39  ARG A CD    1 
ATOM   241  N  NE    . ARG A 1 30  ? -31.164 12.029  -16.641 1.00 70.62  ? 39  ARG A NE    1 
ATOM   242  C  CZ    . ARG A 1 30  ? -31.788 11.584  -15.541 1.00 87.72  ? 39  ARG A CZ    1 
ATOM   243  N  NH1   . ARG A 1 30  ? -31.165 11.481  -14.374 1.00 83.20  ? 39  ARG A NH1   1 
ATOM   244  N  NH2   . ARG A 1 30  ? -33.056 11.214  -15.627 1.00 92.95  ? 39  ARG A NH2   1 
ATOM   245  N  N     . LEU A 1 31  ? -27.616 7.837   -15.604 1.00 51.75  ? 40  LEU A N     1 
ATOM   246  C  CA    . LEU A 1 31  ? -27.570 7.174   -14.268 1.00 54.36  ? 40  LEU A CA    1 
ATOM   247  C  C     . LEU A 1 31  ? -26.131 6.775   -13.927 1.00 50.36  ? 40  LEU A C     1 
ATOM   248  O  O     . LEU A 1 31  ? -25.735 6.910   -12.728 1.00 50.35  ? 40  LEU A O     1 
ATOM   249  C  CB    . LEU A 1 31  ? -28.498 5.959   -14.246 1.00 52.16  ? 40  LEU A CB    1 
ATOM   250  C  CG    . LEU A 1 31  ? -29.973 6.280   -14.444 1.00 53.67  ? 40  LEU A CG    1 
ATOM   251  C  CD1   . LEU A 1 31  ? -30.815 5.052   -14.154 1.00 60.52  ? 40  LEU A CD1   1 
ATOM   252  C  CD2   . LEU A 1 31  ? -30.408 7.431   -13.562 1.00 62.34  ? 40  LEU A CD2   1 
ATOM   253  N  N     . VAL A 1 32  ? -25.387 6.277   -14.912 1.00 46.73  ? 41  VAL A N     1 
ATOM   254  C  CA    . VAL A 1 32  ? -23.947 5.932   -14.731 1.00 47.33  ? 41  VAL A CA    1 
ATOM   255  C  C     . VAL A 1 32  ? -23.243 7.216   -14.309 1.00 47.46  ? 41  VAL A C     1 
ATOM   256  O  O     . VAL A 1 32  ? -22.564 7.190   -13.263 1.00 57.54  ? 41  VAL A O     1 
ATOM   257  C  CB    . VAL A 1 32  ? -23.306 5.301   -15.977 1.00 52.04  ? 41  VAL A CB    1 
ATOM   258  C  CG1   . VAL A 1 32  ? -21.822 4.995   -15.772 1.00 51.10  ? 41  VAL A CG1   1 
ATOM   259  C  CG2   . VAL A 1 32  ? -24.047 4.038   -16.392 1.00 54.92  ? 41  VAL A CG2   1 
ATOM   260  N  N     . TRP A 1 33  ? -23.421 8.296   -15.069 1.00 46.17  ? 42  TRP A N     1 
ATOM   261  C  CA    . TRP A 1 33  ? -22.688 9.566   -14.825 1.00 51.44  ? 42  TRP A CA    1 
ATOM   262  C  C     . TRP A 1 33  ? -22.963 10.049  -13.391 1.00 49.96  ? 42  TRP A C     1 
ATOM   263  O  O     . TRP A 1 33  ? -21.993 10.387  -12.721 1.00 42.63  ? 42  TRP A O     1 
ATOM   264  C  CB    . TRP A 1 33  ? -23.002 10.620  -15.891 1.00 45.99  ? 42  TRP A CB    1 
ATOM   265  C  CG    . TRP A 1 33  ? -22.209 10.461  -17.149 1.00 48.04  ? 42  TRP A CG    1 
ATOM   266  C  CD1   . TRP A 1 33  ? -20.885 10.148  -17.236 1.00 48.10  ? 42  TRP A CD1   1 
ATOM   267  C  CD2   . TRP A 1 33  ? -22.675 10.628  -18.505 1.00 47.72  ? 42  TRP A CD2   1 
ATOM   268  N  NE1   . TRP A 1 33  ? -20.502 10.095  -18.548 1.00 54.60  ? 42  TRP A NE1   1 
ATOM   269  C  CE2   . TRP A 1 33  ? -21.580 10.375  -19.351 1.00 50.32  ? 42  TRP A CE2   1 
ATOM   270  C  CE3   . TRP A 1 33  ? -23.902 10.968  -19.089 1.00 56.02  ? 42  TRP A CE3   1 
ATOM   271  C  CZ2   . TRP A 1 33  ? -21.671 10.463  -20.743 1.00 54.70  ? 42  TRP A CZ2   1 
ATOM   272  C  CZ3   . TRP A 1 33  ? -24.001 11.037  -20.466 1.00 58.77  ? 42  TRP A CZ3   1 
ATOM   273  C  CH2   . TRP A 1 33  ? -22.897 10.791  -21.283 1.00 55.64  ? 42  TRP A CH2   1 
ATOM   274  N  N     . GLN A 1 34  ? -24.221 9.985   -12.943 1.00 53.83  ? 43  GLN A N     1 
ATOM   275  C  CA    . GLN A 1 34  ? -24.728 10.532  -11.651 1.00 55.11  ? 43  GLN A CA    1 
ATOM   276  C  C     . GLN A 1 34  ? -24.267 9.693   -10.458 1.00 53.20  ? 43  GLN A C     1 
ATOM   277  O  O     . GLN A 1 34  ? -24.299 10.218  -9.347  1.00 58.31  ? 43  GLN A O     1 
ATOM   278  C  CB    . GLN A 1 34  ? -26.260 10.556  -11.631 1.00 60.91  ? 43  GLN A CB    1 
ATOM   279  C  CG    . GLN A 1 34  ? -26.872 11.857  -12.129 1.00 67.47  ? 43  GLN A CG    1 
ATOM   280  C  CD    . GLN A 1 34  ? -28.378 11.772  -12.217 1.00 78.49  ? 43  GLN A CD    1 
ATOM   281  O  OE1   . GLN A 1 34  ? -28.946 11.489  -13.269 1.00 79.17  ? 43  GLN A OE1   1 
ATOM   282  N  NE2   . GLN A 1 34  ? -29.053 12.021  -11.106 1.00 88.84  ? 43  GLN A NE2   1 
ATOM   283  N  N     . SER A 1 35  ? -23.844 8.450   -10.681 1.00 56.67  ? 44  SER A N     1 
ATOM   284  C  CA    . SER A 1 35  ? -23.640 7.417   -9.631  1.00 53.75  ? 44  SER A CA    1 
ATOM   285  C  C     . SER A 1 35  ? -22.153 7.313   -9.251  1.00 53.67  ? 44  SER A C     1 
ATOM   286  O  O     . SER A 1 35  ? -21.311 7.385   -10.150 1.00 62.80  ? 44  SER A O     1 
ATOM   287  C  CB    . SER A 1 35  ? -24.176 6.098   -10.118 1.00 55.18  ? 44  SER A CB    1 
ATOM   288  O  OG    . SER A 1 35  ? -25.599 6.116   -10.185 1.00 59.85  ? 44  SER A OG    1 
ATOM   289  N  N     . SER A 1 36  ? -21.844 7.086   -7.973  1.00 42.57  ? 45  SER A N     1 
ATOM   290  C  CA    . SER A 1 36  ? -20.460 6.971   -7.461  1.00 48.88  ? 45  SER A CA    1 
ATOM   291  C  C     . SER A 1 36  ? -20.080 5.507   -7.249  1.00 48.17  ? 45  SER A C     1 
ATOM   292  O  O     . SER A 1 36  ? -18.967 5.273   -6.832  1.00 57.76  ? 45  SER A O     1 
ATOM   293  C  CB    . SER A 1 36  ? -20.270 7.774   -6.195  1.00 57.45  ? 45  SER A CB    1 
ATOM   294  O  OG    . SER A 1 36  ? -21.252 7.476   -5.220  1.00 56.43  ? 45  SER A OG    1 
ATOM   295  N  N     . SER A 1 37  ? -20.963 4.564   -7.559  1.00 46.55  ? 46  SER A N     1 
ATOM   296  C  CA    . SER A 1 37  ? -20.807 3.142   -7.175  1.00 51.75  ? 46  SER A CA    1 
ATOM   297  C  C     . SER A 1 37  ? -21.750 2.246   -8.014  1.00 47.06  ? 46  SER A C     1 
ATOM   298  O  O     . SER A 1 37  ? -22.895 2.055   -7.632  1.00 46.62  ? 46  SER A O     1 
ATOM   299  C  CB    . SER A 1 37  ? -21.023 3.011   -5.683  1.00 52.32  ? 46  SER A CB    1 
ATOM   300  O  OG    . SER A 1 37  ? -20.355 1.881   -5.187  1.00 52.42  ? 46  SER A OG    1 
ATOM   301  N  N     . VAL A 1 38  ? -21.243 1.730   -9.136  1.00 50.22  ? 47  VAL A N     1 
ATOM   302  C  CA    . VAL A 1 38  ? -21.984 0.921   -10.144 1.00 50.13  ? 47  VAL A CA    1 
ATOM   303  C  C     . VAL A 1 38  ? -21.559 -0.542  -10.002 1.00 45.73  ? 47  VAL A C     1 
ATOM   304  O  O     . VAL A 1 38  ? -20.385 -0.836  -10.235 1.00 46.01  ? 47  VAL A O     1 
ATOM   305  C  CB    . VAL A 1 38  ? -21.736 1.435   -11.567 1.00 48.33  ? 47  VAL A CB    1 
ATOM   306  C  CG1   . VAL A 1 38  ? -22.585 0.695   -12.578 1.00 54.33  ? 47  VAL A CG1   1 
ATOM   307  C  CG2   . VAL A 1 38  ? -21.986 2.931   -11.659 1.00 58.85  ? 47  VAL A CG2   1 
ATOM   308  N  N     . VAL A 1 39  ? -22.491 -1.411  -9.609  1.00 39.54  ? 48  VAL A N     1 
ATOM   309  C  CA    . VAL A 1 39  ? -22.330 -2.884  -9.725  1.00 37.32  ? 48  VAL A CA    1 
ATOM   310  C  C     . VAL A 1 39  ? -23.085 -3.370  -10.950 1.00 34.85  ? 48  VAL A C     1 
ATOM   311  O  O     . VAL A 1 39  ? -24.155 -2.868  -11.179 1.00 32.68  ? 48  VAL A O     1 
ATOM   312  C  CB    . VAL A 1 39  ? -22.882 -3.552  -8.480  1.00 38.10  ? 48  VAL A CB    1 
ATOM   313  C  CG1   . VAL A 1 39  ? -22.793 -5.051  -8.606  1.00 36.65  ? 48  VAL A CG1   1 
ATOM   314  C  CG2   . VAL A 1 39  ? -22.169 -2.996  -7.249  1.00 46.97  ? 48  VAL A CG2   1 
ATOM   315  N  N     . PHE A 1 40  ? -22.548 -4.350  -11.664 1.00 37.17  ? 49  PHE A N     1 
ATOM   316  C  CA    . PHE A 1 40  ? -23.260 -5.062  -12.744 1.00 37.09  ? 49  PHE A CA    1 
ATOM   317  C  C     . PHE A 1 40  ? -23.576 -6.464  -12.247 1.00 36.86  ? 49  PHE A C     1 
ATOM   318  O  O     . PHE A 1 40  ? -22.718 -7.042  -11.572 1.00 34.21  ? 49  PHE A O     1 
ATOM   319  C  CB    . PHE A 1 40  ? -22.430 -5.106  -14.023 1.00 39.24  ? 49  PHE A CB    1 
ATOM   320  C  CG    . PHE A 1 40  ? -22.501 -3.863  -14.866 1.00 37.28  ? 49  PHE A CG    1 
ATOM   321  C  CD1   . PHE A 1 40  ? -21.727 -2.762  -14.554 1.00 41.55  ? 49  PHE A CD1   1 
ATOM   322  C  CD2   . PHE A 1 40  ? -23.281 -3.826  -15.995 1.00 36.51  ? 49  PHE A CD2   1 
ATOM   323  C  CE1   . PHE A 1 40  ? -21.769 -1.620  -15.327 1.00 41.46  ? 49  PHE A CE1   1 
ATOM   324  C  CE2   . PHE A 1 40  ? -23.291 -2.704  -16.794 1.00 40.82  ? 49  PHE A CE2   1 
ATOM   325  C  CZ    . PHE A 1 40  ? -22.551 -1.601  -16.449 1.00 47.12  ? 49  PHE A CZ    1 
ATOM   326  N  N     . HIS A 1 41  ? -24.762 -6.967  -12.618 1.00 35.09  ? 50  HIS A N     1 
ATOM   327  C  CA    . HIS A 1 41  ? -25.181 -8.382  -12.455 1.00 35.03  ? 50  HIS A CA    1 
ATOM   328  C  C     . HIS A 1 41  ? -25.409 -9.024  -13.838 1.00 35.77  ? 50  HIS A C     1 
ATOM   329  O  O     . HIS A 1 41  ? -26.337 -8.567  -14.592 1.00 33.25  ? 50  HIS A O     1 
ATOM   330  C  CB    . HIS A 1 41  ? -26.437 -8.428  -11.590 1.00 34.63  ? 50  HIS A CB    1 
ATOM   331  C  CG    . HIS A 1 41  ? -26.267 -7.753  -10.274 1.00 32.22  ? 50  HIS A CG    1 
ATOM   332  N  ND1   . HIS A 1 41  ? -26.293 -6.399  -10.146 1.00 35.00  ? 50  HIS A ND1   1 
ATOM   333  C  CD2   . HIS A 1 41  ? -26.116 -8.250  -9.031  1.00 32.98  ? 50  HIS A CD2   1 
ATOM   334  C  CE1   . HIS A 1 41  ? -26.133 -6.078  -8.871  1.00 33.83  ? 50  HIS A CE1   1 
ATOM   335  N  NE2   . HIS A 1 41  ? -26.051 -7.186  -8.169  1.00 32.97  ? 50  HIS A NE2   1 
ATOM   336  N  N     . THR A 1 42  ? -24.619 -10.037 -14.188 1.00 31.04  ? 51  THR A N     1 
ATOM   337  C  CA    . THR A 1 42  ? -24.779 -10.719 -15.501 1.00 37.50  ? 51  THR A CA    1 
ATOM   338  C  C     . THR A 1 42  ? -25.297 -12.156 -15.373 1.00 36.43  ? 51  THR A C     1 
ATOM   339  O  O     . THR A 1 42  ? -24.927 -12.875 -14.441 1.00 39.96  ? 51  THR A O     1 
ATOM   340  C  CB    . THR A 1 42  ? -23.495 -10.700 -16.340 1.00 32.92  ? 51  THR A CB    1 
ATOM   341  O  OG1   . THR A 1 42  ? -22.439 -11.390 -15.693 1.00 29.49  ? 51  THR A OG1   1 
ATOM   342  C  CG2   . THR A 1 42  ? -23.044 -9.300  -16.654 1.00 33.42  ? 51  THR A CG2   1 
ATOM   343  N  N     . GLY A 1 43  ? -26.091 -12.559 -16.353 1.00 37.88  ? 52  GLY A N     1 
ATOM   344  C  CA    . GLY A 1 43  ? -26.559 -13.950 -16.564 1.00 41.24  ? 52  GLY A CA    1 
ATOM   345  C  C     . GLY A 1 43  ? -26.308 -14.405 -18.002 1.00 38.41  ? 52  GLY A C     1 
ATOM   346  O  O     . GLY A 1 43  ? -25.835 -13.591 -18.800 1.00 36.94  ? 52  GLY A O     1 
ATOM   347  N  N     . ALA A 1 44  ? -26.723 -15.616 -18.353 1.00 34.94  ? 53  ALA A N     1 
ATOM   348  C  CA    . ALA A 1 44  ? -26.409 -16.303 -19.629 1.00 37.34  ? 53  ALA A CA    1 
ATOM   349  C  C     . ALA A 1 44  ? -26.796 -15.525 -20.904 1.00 35.11  ? 53  ALA A C     1 
ATOM   350  O  O     . ALA A 1 44  ? -26.400 -15.964 -21.978 1.00 46.05  ? 53  ALA A O     1 
ATOM   351  C  CB    . ALA A 1 44  ? -27.095 -17.641 -19.616 1.00 42.62  ? 53  ALA A CB    1 
ATOM   352  N  N     . GLY A 1 45  ? -27.602 -14.478 -20.827 1.00 36.28  ? 54  GLY A N     1 
ATOM   353  C  CA    . GLY A 1 45  ? -28.015 -13.627 -21.970 1.00 37.59  ? 54  GLY A CA    1 
ATOM   354  C  C     . GLY A 1 45  ? -26.860 -12.827 -22.558 1.00 36.40  ? 54  GLY A C     1 
ATOM   355  O  O     . GLY A 1 45  ? -26.930 -12.464 -23.741 1.00 37.25  ? 54  GLY A O     1 
ATOM   356  N  N     . ILE A 1 46  ? -25.786 -12.610 -21.791 1.00 36.64  ? 55  ILE A N     1 
ATOM   357  C  CA    . ILE A 1 46  ? -24.605 -11.903 -22.335 1.00 31.27  ? 55  ILE A CA    1 
ATOM   358  C  C     . ILE A 1 46  ? -23.763 -12.860 -23.163 1.00 29.40  ? 55  ILE A C     1 
ATOM   359  O  O     . ILE A 1 46  ? -22.826 -12.347 -23.781 1.00 27.80  ? 55  ILE A O     1 
ATOM   360  C  CB    . ILE A 1 46  ? -23.783 -11.202 -21.249 1.00 38.46  ? 55  ILE A CB    1 
ATOM   361  C  CG1   . ILE A 1 46  ? -22.929 -12.144 -20.424 1.00 36.25  ? 55  ILE A CG1   1 
ATOM   362  C  CG2   . ILE A 1 46  ? -24.635 -10.306 -20.352 1.00 41.96  ? 55  ILE A CG2   1 
ATOM   363  C  CD1   . ILE A 1 46  ? -22.065 -11.340 -19.485 1.00 36.99  ? 55  ILE A CD1   1 
ATOM   364  N  N     . SER A 1 47  ? -24.093 -14.162 -23.187 1.00 32.26  ? 56  SER A N     1 
ATOM   365  C  CA    . SER A 1 47  ? -23.274 -15.230 -23.826 1.00 33.54  ? 56  SER A CA    1 
ATOM   366  C  C     . SER A 1 47  ? -23.924 -15.842 -25.073 1.00 32.04  ? 56  SER A C     1 
ATOM   367  O  O     . SER A 1 47  ? -23.277 -16.627 -25.720 1.00 36.70  ? 56  SER A O     1 
ATOM   368  C  CB    . SER A 1 47  ? -22.916 -16.277 -22.818 1.00 33.20  ? 56  SER A CB    1 
ATOM   369  O  OG    . SER A 1 47  ? -21.953 -15.760 -21.922 1.00 31.50  ? 56  SER A OG    1 
ATOM   370  N  N     . THR A 1 48  ? -25.152 -15.486 -25.400 1.00 33.64  ? 57  THR A N     1 
ATOM   371  C  CA    . THR A 1 48  ? -25.929 -16.055 -26.509 1.00 32.93  ? 57  THR A CA    1 
ATOM   372  C  C     . THR A 1 48  ? -25.359 -15.580 -27.845 1.00 33.08  ? 57  THR A C     1 
ATOM   373  O  O     . THR A 1 48  ? -25.332 -16.371 -28.764 1.00 37.15  ? 57  THR A O     1 
ATOM   374  C  CB    . THR A 1 48  ? -27.420 -15.734 -26.335 1.00 37.19  ? 57  THR A CB    1 
ATOM   375  O  OG1   . THR A 1 48  ? -27.591 -14.394 -25.860 1.00 36.73  ? 57  THR A OG1   1 
ATOM   376  C  CG2   . THR A 1 48  ? -28.110 -16.665 -25.365 1.00 37.24  ? 57  THR A CG2   1 
ATOM   377  N  N     . ALA A 1 49  ? -24.889 -14.345 -27.947 1.00 40.01  ? 58  ALA A N     1 
ATOM   378  C  CA    . ALA A 1 49  ? -24.260 -13.797 -29.173 1.00 37.12  ? 58  ALA A CA    1 
ATOM   379  C  C     . ALA A 1 49  ? -22.892 -14.425 -29.420 1.00 37.69  ? 58  ALA A C     1 
ATOM   380  O  O     . ALA A 1 49  ? -22.315 -14.178 -30.523 1.00 46.19  ? 58  ALA A O     1 
ATOM   381  C  CB    . ALA A 1 49  ? -24.172 -12.296 -29.072 1.00 38.71  ? 58  ALA A CB    1 
ATOM   382  N  N     . SER A 1 50  ? -22.379 -15.238 -28.489 1.00 35.40  ? 59  SER A N     1 
ATOM   383  C  CA    . SER A 1 50  ? -21.102 -15.975 -28.692 1.00 34.21  ? 59  SER A CA    1 
ATOM   384  C  C     . SER A 1 50  ? -21.356 -17.476 -28.879 1.00 31.37  ? 59  SER A C     1 
ATOM   385  O  O     . SER A 1 50  ? -20.398 -18.240 -28.836 1.00 35.53  ? 59  SER A O     1 
ATOM   386  C  CB    . SER A 1 50  ? -20.072 -15.671 -27.608 1.00 40.14  ? 59  SER A CB    1 
ATOM   387  O  OG    . SER A 1 50  ? -20.491 -16.176 -26.329 1.00 51.00  ? 59  SER A OG    1 
ATOM   388  N  N     . GLY A 1 51  ? -22.604 -17.869 -29.089 1.00 36.99  ? 60  GLY A N     1 
ATOM   389  C  CA    . GLY A 1 51  ? -22.999 -19.219 -29.528 1.00 38.47  ? 60  GLY A CA    1 
ATOM   390  C  C     . GLY A 1 51  ? -23.468 -20.130 -28.406 1.00 39.73  ? 60  GLY A C     1 
ATOM   391  O  O     . GLY A 1 51  ? -23.812 -21.288 -28.738 1.00 37.10  ? 60  GLY A O     1 
ATOM   392  N  N     . ILE A 1 52  ? -23.575 -19.615 -27.166 1.00 39.62  ? 61  ILE A N     1 
ATOM   393  C  CA    . ILE A 1 52  ? -23.970 -20.383 -25.952 1.00 35.89  ? 61  ILE A CA    1 
ATOM   394  C  C     . ILE A 1 52  ? -25.442 -20.126 -25.648 1.00 38.20  ? 61  ILE A C     1 
ATOM   395  O  O     . ILE A 1 52  ? -25.841 -19.009 -25.382 1.00 39.78  ? 61  ILE A O     1 
ATOM   396  C  CB    . ILE A 1 52  ? -23.088 -19.998 -24.755 1.00 39.16  ? 61  ILE A CB    1 
ATOM   397  C  CG1   . ILE A 1 52  ? -21.659 -20.511 -24.952 1.00 35.46  ? 61  ILE A CG1   1 
ATOM   398  C  CG2   . ILE A 1 52  ? -23.731 -20.504 -23.460 1.00 39.61  ? 61  ILE A CG2   1 
ATOM   399  C  CD1   . ILE A 1 52  ? -20.667 -19.924 -23.992 1.00 40.19  ? 61  ILE A CD1   1 
ATOM   400  N  N     . PRO A 1 53  ? -26.309 -21.159 -25.630 1.00 35.08  ? 62  PRO A N     1 
ATOM   401  C  CA    . PRO A 1 53  ? -27.723 -20.947 -25.385 1.00 36.05  ? 62  PRO A CA    1 
ATOM   402  C  C     . PRO A 1 53  ? -27.938 -20.724 -23.885 1.00 43.56  ? 62  PRO A C     1 
ATOM   403  O  O     . PRO A 1 53  ? -27.076 -21.123 -23.117 1.00 38.11  ? 62  PRO A O     1 
ATOM   404  C  CB    . PRO A 1 53  ? -28.378 -22.237 -25.856 1.00 34.83  ? 62  PRO A CB    1 
ATOM   405  C  CG    . PRO A 1 53  ? -27.301 -23.274 -25.712 1.00 36.83  ? 62  PRO A CG    1 
ATOM   406  C  CD    . PRO A 1 53  ? -25.979 -22.566 -25.837 1.00 35.69  ? 62  PRO A CD    1 
ATOM   407  N  N     . ASP A 1 54  ? -29.032 -20.041 -23.537 1.00 42.16  ? 63  ASP A N     1 
ATOM   408  C  CA    . ASP A 1 54  ? -29.313 -19.616 -22.145 1.00 44.29  ? 63  ASP A CA    1 
ATOM   409  C  C     . ASP A 1 54  ? -30.078 -20.756 -21.479 1.00 40.75  ? 63  ASP A C     1 
ATOM   410  O  O     . ASP A 1 54  ? -30.096 -21.873 -22.029 1.00 40.96  ? 63  ASP A O     1 
ATOM   411  C  CB    . ASP A 1 54  ? -29.956 -18.224 -22.105 1.00 37.88  ? 63  ASP A CB    1 
ATOM   412  C  CG    . ASP A 1 54  ? -31.240 -18.095 -22.905 1.00 37.89  ? 63  ASP A CG    1 
ATOM   413  O  OD1   . ASP A 1 54  ? -31.879 -19.117 -23.170 1.00 31.48  ? 63  ASP A OD1   1 
ATOM   414  O  OD2   . ASP A 1 54  ? -31.590 -16.962 -23.237 1.00 33.85  ? 63  ASP A OD2   1 
ATOM   415  N  N     . PHE A 1 55  ? -30.768 -20.466 -20.397 1.00 39.94  ? 64  PHE A N     1 
ATOM   416  C  CA    . PHE A 1 55  ? -31.570 -21.510 -19.725 1.00 44.45  ? 64  PHE A CA    1 
ATOM   417  C  C     . PHE A 1 55  ? -33.054 -21.297 -19.977 1.00 39.23  ? 64  PHE A C     1 
ATOM   418  O  O     . PHE A 1 55  ? -33.704 -22.219 -20.312 1.00 35.16  ? 64  PHE A O     1 
ATOM   419  C  CB    . PHE A 1 55  ? -31.253 -21.486 -18.235 1.00 42.52  ? 64  PHE A CB    1 
ATOM   420  C  CG    . PHE A 1 55  ? -29.855 -21.937 -17.915 1.00 38.17  ? 64  PHE A CG    1 
ATOM   421  C  CD1   . PHE A 1 55  ? -29.552 -23.280 -17.785 1.00 38.39  ? 64  PHE A CD1   1 
ATOM   422  C  CD2   . PHE A 1 55  ? -28.841 -21.009 -17.751 1.00 36.98  ? 64  PHE A CD2   1 
ATOM   423  C  CE1   . PHE A 1 55  ? -28.264 -23.696 -17.501 1.00 36.82  ? 64  PHE A CE1   1 
ATOM   424  C  CE2   . PHE A 1 55  ? -27.549 -21.418 -17.460 1.00 37.26  ? 64  PHE A CE2   1 
ATOM   425  C  CZ    . PHE A 1 55  ? -27.253 -22.760 -17.356 1.00 36.61  ? 64  PHE A CZ    1 
ATOM   426  N  N     . ARG A 1 56  ? -33.546 -20.076 -19.866 1.00 37.85  ? 65  ARG A N     1 
ATOM   427  C  CA    . ARG A 1 56  ? -35.009 -19.875 -19.828 1.00 39.35  ? 65  ARG A CA    1 
ATOM   428  C  C     . ARG A 1 56  ? -35.468 -19.045 -21.017 1.00 39.60  ? 65  ARG A C     1 
ATOM   429  O  O     . ARG A 1 56  ? -36.580 -18.580 -21.011 1.00 40.87  ? 65  ARG A O     1 
ATOM   430  C  CB    . ARG A 1 56  ? -35.425 -19.305 -18.479 1.00 37.51  ? 65  ARG A CB    1 
ATOM   431  C  CG    . ARG A 1 56  ? -35.134 -20.252 -17.325 1.00 36.18  ? 65  ARG A CG    1 
ATOM   432  C  CD    . ARG A 1 56  ? -35.590 -19.644 -16.008 1.00 36.38  ? 65  ARG A CD    1 
ATOM   433  N  NE    . ARG A 1 56  ? -35.024 -20.474 -14.980 1.00 37.85  ? 65  ARG A NE    1 
ATOM   434  C  CZ    . ARG A 1 56  ? -33.793 -20.333 -14.506 1.00 41.71  ? 65  ARG A CZ    1 
ATOM   435  N  NH1   . ARG A 1 56  ? -32.995 -19.371 -14.945 1.00 48.90  ? 65  ARG A NH1   1 
ATOM   436  N  NH2   . ARG A 1 56  ? -33.351 -21.134 -13.574 1.00 44.93  ? 65  ARG A NH2   1 
ATOM   437  N  N     . GLY A 1 57  ? -34.642 -18.895 -22.025 1.00 40.98  ? 66  GLY A N     1 
ATOM   438  C  CA    . GLY A 1 57  ? -35.044 -18.183 -23.248 1.00 38.08  ? 66  GLY A CA    1 
ATOM   439  C  C     . GLY A 1 57  ? -35.764 -19.136 -24.184 1.00 40.19  ? 66  GLY A C     1 
ATOM   440  O  O     . GLY A 1 57  ? -35.792 -20.315 -23.933 1.00 44.29  ? 66  GLY A O     1 
ATOM   441  N  N     . PRO A 1 58  ? -36.322 -18.653 -25.286 1.00 39.45  ? 67  PRO A N     1 
ATOM   442  C  CA    . PRO A 1 58  ? -37.019 -19.472 -26.242 1.00 40.79  ? 67  PRO A CA    1 
ATOM   443  C  C     . PRO A 1 58  ? -36.302 -20.743 -26.641 1.00 41.97  ? 67  PRO A C     1 
ATOM   444  O  O     . PRO A 1 58  ? -36.944 -21.706 -26.742 1.00 40.25  ? 67  PRO A O     1 
ATOM   445  C  CB    . PRO A 1 58  ? -36.894 -18.610 -27.481 1.00 41.68  ? 67  PRO A CB    1 
ATOM   446  C  CG    . PRO A 1 58  ? -37.124 -17.254 -26.944 1.00 44.73  ? 67  PRO A CG    1 
ATOM   447  C  CD    . PRO A 1 58  ? -36.362 -17.246 -25.641 1.00 44.11  ? 67  PRO A CD    1 
ATOM   448  N  N     . HIS A 1 59  ? -34.998 -20.697 -26.905 1.00 39.47  ? 68  HIS A N     1 
ATOM   449  C  CA    . HIS A 1 59  ? -34.259 -21.941 -27.208 1.00 37.54  ? 68  HIS A CA    1 
ATOM   450  C  C     . HIS A 1 59  ? -33.337 -22.258 -26.035 1.00 35.77  ? 68  HIS A C     1 
ATOM   451  O  O     . HIS A 1 59  ? -32.331 -22.880 -26.223 1.00 40.04  ? 68  HIS A O     1 
ATOM   452  C  CB    . HIS A 1 59  ? -33.561 -21.852 -28.555 1.00 38.53  ? 68  HIS A CB    1 
ATOM   453  C  CG    . HIS A 1 59  ? -34.461 -21.651 -29.724 1.00 42.33  ? 68  HIS A CG    1 
ATOM   454  N  ND1   . HIS A 1 59  ? -33.948 -21.532 -30.981 1.00 41.04  ? 68  HIS A ND1   1 
ATOM   455  C  CD2   . HIS A 1 59  ? -35.803 -21.553 -29.844 1.00 40.75  ? 68  HIS A CD2   1 
ATOM   456  C  CE1   . HIS A 1 59  ? -34.933 -21.349 -31.827 1.00 48.46  ? 68  HIS A CE1   1 
ATOM   457  N  NE2   . HIS A 1 59  ? -36.087 -21.359 -31.142 1.00 46.61  ? 68  HIS A NE2   1 
ATOM   458  N  N     . GLY A 1 60  ? -33.676 -21.803 -24.845 1.00 40.80  ? 69  GLY A N     1 
ATOM   459  C  CA    . GLY A 1 60  ? -32.868 -22.051 -23.634 1.00 40.50  ? 69  GLY A CA    1 
ATOM   460  C  C     . GLY A 1 60  ? -32.964 -23.500 -23.187 1.00 42.69  ? 69  GLY A C     1 
ATOM   461  O  O     . GLY A 1 60  ? -33.993 -24.169 -23.444 1.00 47.44  ? 69  GLY A O     1 
ATOM   462  N  N     . VAL A 1 61  ? -31.939 -23.976 -22.496 1.00 46.13  ? 70  VAL A N     1 
ATOM   463  C  CA    . VAL A 1 61  ? -31.786 -25.428 -22.172 1.00 47.23  ? 70  VAL A CA    1 
ATOM   464  C  C     . VAL A 1 61  ? -33.079 -25.934 -21.517 1.00 43.40  ? 70  VAL A C     1 
ATOM   465  O  O     . VAL A 1 61  ? -33.603 -26.969 -21.984 1.00 41.30  ? 70  VAL A O     1 
ATOM   466  C  CB    . VAL A 1 61  ? -30.589 -25.692 -21.241 1.00 46.86  ? 70  VAL A CB    1 
ATOM   467  C  CG1   . VAL A 1 61  ? -30.424 -27.179 -20.993 1.00 51.54  ? 70  VAL A CG1   1 
ATOM   468  C  CG2   . VAL A 1 61  ? -29.293 -25.068 -21.760 1.00 49.49  ? 70  VAL A CG2   1 
ATOM   469  N  N     . TRP A 1 62  ? -33.538 -25.269 -20.454 1.00 43.99  ? 71  TRP A N     1 
ATOM   470  C  CA    . TRP A 1 62  ? -34.766 -25.673 -19.718 1.00 47.15  ? 71  TRP A CA    1 
ATOM   471  C  C     . TRP A 1 62  ? -35.951 -25.567 -20.675 1.00 50.36  ? 71  TRP A C     1 
ATOM   472  O  O     . TRP A 1 62  ? -36.754 -26.500 -20.711 1.00 50.06  ? 71  TRP A O     1 
ATOM   473  C  CB    . TRP A 1 62  ? -35.038 -24.852 -18.453 1.00 48.86  ? 71  TRP A CB    1 
ATOM   474  C  CG    . TRP A 1 62  ? -33.945 -24.772 -17.430 1.00 43.43  ? 71  TRP A CG    1 
ATOM   475  C  CD1   . TRP A 1 62  ? -33.736 -23.726 -16.583 1.00 44.92  ? 71  TRP A CD1   1 
ATOM   476  C  CD2   . TRP A 1 62  ? -32.906 -25.722 -17.139 1.00 50.61  ? 71  TRP A CD2   1 
ATOM   477  N  NE1   . TRP A 1 62  ? -32.671 -23.960 -15.765 1.00 45.60  ? 71  TRP A NE1   1 
ATOM   478  C  CE2   . TRP A 1 62  ? -32.127 -25.170 -16.093 1.00 50.31  ? 71  TRP A CE2   1 
ATOM   479  C  CE3   . TRP A 1 62  ? -32.563 -26.986 -17.634 1.00 56.13  ? 71  TRP A CE3   1 
ATOM   480  C  CZ2   . TRP A 1 62  ? -31.037 -25.835 -15.541 1.00 51.32  ? 71  TRP A CZ2   1 
ATOM   481  C  CZ3   . TRP A 1 62  ? -31.480 -27.643 -17.092 1.00 57.95  ? 71  TRP A CZ3   1 
ATOM   482  C  CH2   . TRP A 1 62  ? -30.726 -27.071 -16.065 1.00 58.10  ? 71  TRP A CH2   1 
ATOM   483  N  N     . THR A 1 63  ? -36.031 -24.478 -21.439 1.00 51.52  ? 72  THR A N     1 
ATOM   484  C  CA    . THR A 1 63  ? -37.180 -24.182 -22.335 1.00 47.08  ? 72  THR A CA    1 
ATOM   485  C  C     . THR A 1 63  ? -37.311 -25.263 -23.412 1.00 47.47  ? 72  THR A C     1 
ATOM   486  O  O     . THR A 1 63  ? -38.431 -25.647 -23.697 1.00 48.99  ? 72  THR A O     1 
ATOM   487  C  CB    . THR A 1 63  ? -37.067 -22.759 -22.876 1.00 42.88  ? 72  THR A CB    1 
ATOM   488  O  OG1   . THR A 1 63  ? -37.121 -22.007 -21.669 1.00 42.43  ? 72  THR A OG1   1 
ATOM   489  C  CG2   . THR A 1 63  ? -38.180 -22.363 -23.825 1.00 44.76  ? 72  THR A CG2   1 
ATOM   490  N  N     . MET A 1 64  ? -36.214 -25.727 -24.002 1.00 48.80  ? 73  MET A N     1 
ATOM   491  C  CA    . MET A 1 64  ? -36.277 -26.789 -25.031 1.00 51.25  ? 73  MET A CA    1 
ATOM   492  C  C     . MET A 1 64  ? -36.611 -28.135 -24.365 1.00 51.74  ? 73  MET A C     1 
ATOM   493  O  O     . MET A 1 64  ? -37.380 -28.926 -24.977 1.00 50.10  ? 73  MET A O     1 
ATOM   494  C  CB    . MET A 1 64  ? -34.944 -26.865 -25.772 1.00 58.62  ? 73  MET A CB    1 
ATOM   495  C  CG    . MET A 1 64  ? -34.659 -25.627 -26.603 1.00 56.84  ? 73  MET A CG    1 
ATOM   496  S  SD    . MET A 1 64  ? -36.037 -25.221 -27.707 1.00 60.01  ? 73  MET A SD    1 
ATOM   497  C  CE    . MET A 1 64  ? -35.197 -25.286 -29.287 1.00 70.57  ? 73  MET A CE    1 
ATOM   498  N  N     . GLU A 1 65  ? -36.066 -28.394 -23.170 1.00 44.11  ? 74  GLU A N     1 
ATOM   499  C  CA    . GLU A 1 65  ? -36.329 -29.629 -22.381 1.00 47.03  ? 74  GLU A CA    1 
ATOM   500  C  C     . GLU A 1 65  ? -37.846 -29.822 -22.237 1.00 50.70  ? 74  GLU A C     1 
ATOM   501  O  O     . GLU A 1 65  ? -38.317 -30.912 -22.561 1.00 51.64  ? 74  GLU A O     1 
ATOM   502  C  CB    . GLU A 1 65  ? -35.685 -29.562 -20.995 1.00 49.74  ? 74  GLU A CB    1 
ATOM   503  C  CG    . GLU A 1 65  ? -35.106 -30.874 -20.539 1.00 57.29  ? 74  GLU A CG    1 
ATOM   504  C  CD    . GLU A 1 65  ? -33.853 -30.694 -19.712 1.00 65.57  ? 74  GLU A CD    1 
ATOM   505  O  OE1   . GLU A 1 65  ? -33.962 -30.763 -18.472 1.00 70.64  ? 74  GLU A OE1   1 
ATOM   506  O  OE2   . GLU A 1 65  ? -32.773 -30.466 -20.322 1.00 72.00  ? 74  GLU A OE2   1 
ATOM   507  N  N     . GLU A 1 66  ? -38.561 -28.794 -21.765 1.00 54.54  ? 75  GLU A N     1 
ATOM   508  C  CA    . GLU A 1 66  ? -40.038 -28.777 -21.567 1.00 56.33  ? 75  GLU A CA    1 
ATOM   509  C  C     . GLU A 1 66  ? -40.795 -29.159 -22.841 1.00 54.41  ? 75  GLU A C     1 
ATOM   510  O  O     . GLU A 1 66  ? -41.902 -29.679 -22.686 1.00 53.26  ? 75  GLU A O     1 
ATOM   511  C  CB    . GLU A 1 66  ? -40.528 -27.394 -21.139 1.00 66.14  ? 75  GLU A CB    1 
ATOM   512  C  CG    . GLU A 1 66  ? -40.870 -27.322 -19.668 1.00 72.09  ? 75  GLU A CG    1 
ATOM   513  C  CD    . GLU A 1 66  ? -40.867 -25.922 -19.089 1.00 74.89  ? 75  GLU A CD    1 
ATOM   514  O  OE1   . GLU A 1 66  ? -41.691 -25.096 -19.526 1.00 69.81  ? 75  GLU A OE1   1 
ATOM   515  O  OE2   . GLU A 1 66  ? -40.028 -25.666 -18.202 1.00 78.14  ? 75  GLU A OE2   1 
ATOM   516  N  N     . ARG A 1 67  ? -40.273 -28.849 -24.038 1.00 58.03  ? 76  ARG A N     1 
ATOM   517  C  CA    . ARG A 1 67  ? -40.941 -29.149 -25.340 1.00 57.75  ? 76  ARG A CA    1 
ATOM   518  C  C     . ARG A 1 67  ? -40.418 -30.479 -25.899 1.00 57.15  ? 76  ARG A C     1 
ATOM   519  O  O     . ARG A 1 67  ? -40.877 -30.894 -26.968 1.00 65.36  ? 76  ARG A O     1 
ATOM   520  C  CB    . ARG A 1 67  ? -40.714 -28.033 -26.367 1.00 62.28  ? 76  ARG A CB    1 
ATOM   521  C  CG    . ARG A 1 67  ? -41.588 -26.800 -26.172 1.00 69.82  ? 76  ARG A CG    1 
ATOM   522  C  CD    . ARG A 1 67  ? -41.107 -25.932 -25.023 1.00 73.22  ? 76  ARG A CD    1 
ATOM   523  N  NE    . ARG A 1 67  ? -41.658 -24.572 -25.020 1.00 80.95  ? 76  ARG A NE    1 
ATOM   524  C  CZ    . ARG A 1 67  ? -41.720 -23.756 -23.956 1.00 76.42  ? 76  ARG A CZ    1 
ATOM   525  N  NH1   . ARG A 1 67  ? -41.268 -24.159 -22.776 1.00 72.43  ? 76  ARG A NH1   1 
ATOM   526  N  NH2   . ARG A 1 67  ? -42.264 -22.549 -24.073 1.00 70.14  ? 76  ARG A NH2   1 
ATOM   527  N  N     . GLY A 1 68  ? -39.470 -31.115 -25.221 1.00 58.68  ? 77  GLY A N     1 
ATOM   528  C  CA    . GLY A 1 68  ? -38.821 -32.355 -25.690 1.00 59.49  ? 77  GLY A CA    1 
ATOM   529  C  C     . GLY A 1 68  ? -37.780 -32.106 -26.768 1.00 54.76  ? 77  GLY A C     1 
ATOM   530  O  O     . GLY A 1 68  ? -37.531 -33.032 -27.538 1.00 52.41  ? 77  GLY A O     1 
ATOM   531  N  N     . LEU A 1 69  ? -37.129 -30.937 -26.786 1.00 53.34  ? 78  LEU A N     1 
ATOM   532  C  CA    . LEU A 1 69  ? -36.086 -30.616 -27.808 1.00 51.45  ? 78  LEU A CA    1 
ATOM   533  C  C     . LEU A 1 69  ? -34.740 -30.442 -27.110 1.00 50.46  ? 78  LEU A C     1 
ATOM   534  O  O     . LEU A 1 69  ? -34.701 -30.551 -25.892 1.00 54.22  ? 78  LEU A O     1 
ATOM   535  C  CB    . LEU A 1 69  ? -36.499 -29.367 -28.591 1.00 53.70  ? 78  LEU A CB    1 
ATOM   536  C  CG    . LEU A 1 69  ? -37.807 -29.531 -29.373 1.00 56.58  ? 78  LEU A CG    1 
ATOM   537  C  CD1   . LEU A 1 69  ? -38.385 -28.186 -29.773 1.00 55.82  ? 78  LEU A CD1   1 
ATOM   538  C  CD2   . LEU A 1 69  ? -37.610 -30.412 -30.599 1.00 52.82  ? 78  LEU A CD2   1 
ATOM   539  N  N     . ALA A 1 70  ? -33.674 -30.252 -27.881 1.00 52.34  ? 79  ALA A N     1 
ATOM   540  C  CA    . ALA A 1 70  ? -32.293 -30.103 -27.383 1.00 54.06  ? 79  ALA A CA    1 
ATOM   541  C  C     . ALA A 1 70  ? -31.828 -28.671 -27.645 1.00 53.53  ? 79  ALA A C     1 
ATOM   542  O  O     . ALA A 1 70  ? -32.003 -28.161 -28.749 1.00 48.28  ? 79  ALA A O     1 
ATOM   543  C  CB    . ALA A 1 70  ? -31.404 -31.127 -28.046 1.00 51.83  ? 79  ALA A CB    1 
ATOM   544  N  N     . PRO A 1 71  ? -31.194 -27.993 -26.658 1.00 49.72  ? 80  PRO A N     1 
ATOM   545  C  CA    . PRO A 1 71  ? -30.531 -26.719 -26.911 1.00 43.97  ? 80  PRO A CA    1 
ATOM   546  C  C     . PRO A 1 71  ? -29.430 -26.911 -27.956 1.00 40.38  ? 80  PRO A C     1 
ATOM   547  O  O     . PRO A 1 71  ? -28.899 -27.943 -28.021 1.00 34.96  ? 80  PRO A O     1 
ATOM   548  C  CB    . PRO A 1 71  ? -29.857 -26.395 -25.562 1.00 51.40  ? 80  PRO A CB    1 
ATOM   549  C  CG    . PRO A 1 71  ? -29.626 -27.750 -24.918 1.00 45.50  ? 80  PRO A CG    1 
ATOM   550  C  CD    . PRO A 1 71  ? -30.920 -28.477 -25.286 1.00 55.21  ? 80  PRO A CD    1 
ATOM   551  N  N     . LYS A 1 72  ? -29.105 -25.878 -28.712 1.00 48.75  ? 81  LYS A N     1 
ATOM   552  C  CA    . LYS A 1 72  ? -28.029 -25.884 -29.728 1.00 42.77  ? 81  LYS A CA    1 
ATOM   553  C  C     . LYS A 1 72  ? -26.897 -24.988 -29.211 1.00 42.76  ? 81  LYS A C     1 
ATOM   554  O  O     . LYS A 1 72  ? -27.173 -23.873 -28.699 1.00 46.54  ? 81  LYS A O     1 
ATOM   555  C  CB    . LYS A 1 72  ? -28.559 -25.349 -31.061 1.00 49.28  ? 81  LYS A CB    1 
ATOM   556  C  CG    . LYS A 1 72  ? -28.209 -26.163 -32.302 1.00 52.08  ? 81  LYS A CG    1 
ATOM   557  C  CD    . LYS A 1 72  ? -26.759 -26.507 -32.450 1.00 57.27  ? 81  LYS A CD    1 
ATOM   558  C  CE    . LYS A 1 72  ? -26.300 -26.513 -33.892 1.00 59.61  ? 81  LYS A CE    1 
ATOM   559  N  NZ    . LYS A 1 72  ? -24.851 -26.792 -33.989 1.00 55.26  ? 81  LYS A NZ    1 
ATOM   560  N  N     . PHE A 1 73  ? -25.679 -25.490 -29.340 1.00 42.07  ? 82  PHE A N     1 
ATOM   561  C  CA    . PHE A 1 73  ? -24.377 -24.844 -29.055 1.00 42.41  ? 82  PHE A CA    1 
ATOM   562  C  C     . PHE A 1 73  ? -23.752 -24.551 -30.415 1.00 44.23  ? 82  PHE A C     1 
ATOM   563  O  O     . PHE A 1 73  ? -23.730 -25.444 -31.259 1.00 46.11  ? 82  PHE A O     1 
ATOM   564  C  CB    . PHE A 1 73  ? -23.507 -25.772 -28.207 1.00 44.41  ? 82  PHE A CB    1 
ATOM   565  C  CG    . PHE A 1 73  ? -23.680 -25.605 -26.717 1.00 48.70  ? 82  PHE A CG    1 
ATOM   566  C  CD1   . PHE A 1 73  ? -24.637 -26.328 -26.020 1.00 48.71  ? 82  PHE A CD1   1 
ATOM   567  C  CD2   . PHE A 1 73  ? -22.883 -24.708 -26.007 1.00 49.69  ? 82  PHE A CD2   1 
ATOM   568  C  CE1   . PHE A 1 73  ? -24.793 -26.152 -24.648 1.00 54.21  ? 82  PHE A CE1   1 
ATOM   569  C  CE2   . PHE A 1 73  ? -23.036 -24.544 -24.635 1.00 50.38  ? 82  PHE A CE2   1 
ATOM   570  C  CZ    . PHE A 1 73  ? -23.993 -25.262 -23.959 1.00 46.76  ? 82  PHE A CZ    1 
ATOM   571  N  N     . ASP A 1 74  ? -23.341 -23.305 -30.636 1.00 45.58  ? 83  ASP A N     1 
ATOM   572  C  CA    . ASP A 1 74  ? -22.678 -22.851 -31.883 1.00 45.74  ? 83  ASP A CA    1 
ATOM   573  C  C     . ASP A 1 74  ? -21.167 -22.771 -31.656 1.00 45.15  ? 83  ASP A C     1 
ATOM   574  O  O     . ASP A 1 74  ? -20.437 -22.399 -32.590 1.00 44.11  ? 83  ASP A O     1 
ATOM   575  C  CB    . ASP A 1 74  ? -23.309 -21.539 -32.314 1.00 48.39  ? 83  ASP A CB    1 
ATOM   576  C  CG    . ASP A 1 74  ? -24.766 -21.777 -32.624 1.00 44.06  ? 83  ASP A CG    1 
ATOM   577  O  OD1   . ASP A 1 74  ? -25.003 -22.584 -33.557 1.00 42.22  ? 83  ASP A OD1   1 
ATOM   578  O  OD2   . ASP A 1 74  ? -25.638 -21.219 -31.892 1.00 42.39  ? 83  ASP A OD2   1 
ATOM   579  N  N     . THR A 1 75  ? -20.718 -23.145 -30.460 1.00 42.19  ? 84  THR A N     1 
ATOM   580  C  CA    . THR A 1 75  ? -19.290 -23.392 -30.177 1.00 41.77  ? 84  THR A CA    1 
ATOM   581  C  C     . THR A 1 75  ? -19.120 -24.197 -28.898 1.00 42.15  ? 84  THR A C     1 
ATOM   582  O  O     . THR A 1 75  ? -20.092 -24.395 -28.138 1.00 41.34  ? 84  THR A O     1 
ATOM   583  C  CB    . THR A 1 75  ? -18.515 -22.075 -30.035 1.00 45.67  ? 84  THR A CB    1 
ATOM   584  O  OG1   . THR A 1 75  ? -17.245 -22.334 -29.431 1.00 44.36  ? 84  THR A OG1   1 
ATOM   585  C  CG2   . THR A 1 75  ? -19.266 -21.046 -29.224 1.00 43.84  ? 84  THR A CG2   1 
ATOM   586  N  N     . THR A 1 76  ? -17.893 -24.636 -28.700 1.00 38.23  ? 85  THR A N     1 
ATOM   587  C  CA    . THR A 1 76  ? -17.445 -25.240 -27.452 1.00 37.78  ? 85  THR A CA    1 
ATOM   588  C  C     . THR A 1 76  ? -17.257 -24.121 -26.442 1.00 43.00  ? 85  THR A C     1 
ATOM   589  O  O     . THR A 1 76  ? -17.062 -22.958 -26.858 1.00 42.21  ? 85  THR A O     1 
ATOM   590  C  CB    . THR A 1 76  ? -16.118 -25.965 -27.665 1.00 40.80  ? 85  THR A CB    1 
ATOM   591  O  OG1   . THR A 1 76  ? -15.235 -24.889 -27.943 1.00 36.66  ? 85  THR A OG1   1 
ATOM   592  C  CG2   . THR A 1 76  ? -16.151 -27.005 -28.767 1.00 43.29  ? 85  THR A CG2   1 
ATOM   593  N  N     . PHE A 1 77  ? -17.142 -24.489 -25.171 1.00 43.11  ? 86  PHE A N     1 
ATOM   594  C  CA    . PHE A 1 77  ? -16.764 -23.542 -24.103 1.00 43.94  ? 86  PHE A CA    1 
ATOM   595  C  C     . PHE A 1 77  ? -15.333 -23.023 -24.354 1.00 47.17  ? 86  PHE A C     1 
ATOM   596  O  O     . PHE A 1 77  ? -15.024 -21.867 -23.988 1.00 49.89  ? 86  PHE A O     1 
ATOM   597  C  CB    . PHE A 1 77  ? -17.028 -24.204 -22.757 1.00 40.26  ? 86  PHE A CB    1 
ATOM   598  C  CG    . PHE A 1 77  ? -18.497 -24.309 -22.427 1.00 35.49  ? 86  PHE A CG    1 
ATOM   599  C  CD1   . PHE A 1 77  ? -19.228 -23.187 -22.105 1.00 35.62  ? 86  PHE A CD1   1 
ATOM   600  C  CD2   . PHE A 1 77  ? -19.131 -25.534 -22.377 1.00 40.01  ? 86  PHE A CD2   1 
ATOM   601  C  CE1   . PHE A 1 77  ? -20.569 -23.280 -21.766 1.00 41.07  ? 86  PHE A CE1   1 
ATOM   602  C  CE2   . PHE A 1 77  ? -20.465 -25.634 -22.038 1.00 37.67  ? 86  PHE A CE2   1 
ATOM   603  C  CZ    . PHE A 1 77  ? -21.190 -24.501 -21.737 1.00 39.71  ? 86  PHE A CZ    1 
ATOM   604  N  N     . GLU A 1 78  ? -14.485 -23.831 -24.986 1.00 45.51  ? 87  GLU A N     1 
ATOM   605  C  CA    . GLU A 1 78  ? -13.053 -23.517 -25.252 1.00 44.65  ? 87  GLU A CA    1 
ATOM   606  C  C     . GLU A 1 78  ? -12.879 -22.534 -26.416 1.00 42.03  ? 87  GLU A C     1 
ATOM   607  O  O     . GLU A 1 78  ? -12.039 -21.668 -26.298 1.00 52.03  ? 87  GLU A O     1 
ATOM   608  C  CB    . GLU A 1 78  ? -12.279 -24.790 -25.589 1.00 42.65  ? 87  GLU A CB    1 
ATOM   609  C  CG    . GLU A 1 78  ? -12.118 -25.695 -24.387 1.00 50.43  ? 87  GLU A CG    1 
ATOM   610  C  CD    . GLU A 1 78  ? -13.249 -26.668 -24.094 1.00 50.24  ? 87  GLU A CD    1 
ATOM   611  O  OE1   . GLU A 1 78  ? -14.248 -26.708 -24.868 1.00 46.99  ? 87  GLU A OE1   1 
ATOM   612  O  OE2   . GLU A 1 78  ? -13.111 -27.398 -23.092 1.00 54.19  ? 87  GLU A OE2   1 
ATOM   613  N  N     . SER A 1 79  ? -13.621 -22.695 -27.503 1.00 38.36  ? 88  SER A N     1 
ATOM   614  C  CA    . SER A 1 79  ? -13.537 -21.853 -28.719 1.00 46.21  ? 88  SER A CA    1 
ATOM   615  C  C     . SER A 1 79  ? -14.486 -20.646 -28.633 1.00 42.13  ? 88  SER A C     1 
ATOM   616  O  O     . SER A 1 79  ? -14.566 -19.862 -29.603 1.00 40.78  ? 88  SER A O     1 
ATOM   617  C  CB    . SER A 1 79  ? -13.800 -22.699 -29.952 1.00 48.83  ? 88  SER A CB    1 
ATOM   618  O  OG    . SER A 1 79  ? -12.738 -23.637 -30.137 1.00 57.33  ? 88  SER A OG    1 
ATOM   619  N  N     . ALA A 1 80  ? -15.209 -20.500 -27.534 1.00 40.26  ? 89  ALA A N     1 
ATOM   620  C  CA    . ALA A 1 80  ? -16.190 -19.409 -27.350 1.00 38.98  ? 89  ALA A CA    1 
ATOM   621  C  C     . ALA A 1 80  ? -15.446 -18.075 -27.181 1.00 40.93  ? 89  ALA A C     1 
ATOM   622  O  O     . ALA A 1 80  ? -14.498 -17.994 -26.369 1.00 48.41  ? 89  ALA A O     1 
ATOM   623  C  CB    . ALA A 1 80  ? -17.048 -19.722 -26.154 1.00 42.07  ? 89  ALA A CB    1 
ATOM   624  N  N     . ARG A 1 81  ? -15.876 -17.051 -27.898 1.00 41.15  ? 90  ARG A N     1 
ATOM   625  C  CA    . ARG A 1 81  ? -15.271 -15.702 -27.844 1.00 47.57  ? 90  ARG A CA    1 
ATOM   626  C  C     . ARG A 1 81  ? -16.193 -14.805 -27.028 1.00 46.01  ? 90  ARG A C     1 
ATOM   627  O  O     . ARG A 1 81  ? -17.390 -14.764 -27.293 1.00 36.22  ? 90  ARG A O     1 
ATOM   628  C  CB    . ARG A 1 81  ? -14.944 -15.217 -29.261 1.00 47.11  ? 90  ARG A CB    1 
ATOM   629  C  CG    . ARG A 1 81  ? -15.799 -14.106 -29.833 1.00 55.16  ? 90  ARG A CG    1 
ATOM   630  C  CD    . ARG A 1 81  ? -14.985 -13.238 -30.784 1.00 63.15  ? 90  ARG A CD    1 
ATOM   631  N  NE    . ARG A 1 81  ? -14.723 -11.924 -30.194 1.00 65.04  ? 90  ARG A NE    1 
ATOM   632  C  CZ    . ARG A 1 81  ? -13.542 -11.312 -30.121 1.00 67.26  ? 90  ARG A CZ    1 
ATOM   633  N  NH1   . ARG A 1 81  ? -12.456 -11.884 -30.616 1.00 62.47  ? 90  ARG A NH1   1 
ATOM   634  N  NH2   . ARG A 1 81  ? -13.462 -10.110 -29.552 1.00 63.09  ? 90  ARG A NH2   1 
ATOM   635  N  N     . PRO A 1 82  ? -15.633 -14.084 -26.022 1.00 43.44  ? 91  PRO A N     1 
ATOM   636  C  CA    . PRO A 1 82  ? -16.364 -13.091 -25.252 1.00 41.55  ? 91  PRO A CA    1 
ATOM   637  C  C     . PRO A 1 82  ? -17.012 -12.110 -26.218 1.00 38.86  ? 91  PRO A C     1 
ATOM   638  O  O     . PRO A 1 82  ? -16.373 -11.859 -27.199 1.00 38.69  ? 91  PRO A O     1 
ATOM   639  C  CB    . PRO A 1 82  ? -15.307 -12.303 -24.476 1.00 43.59  ? 91  PRO A CB    1 
ATOM   640  C  CG    . PRO A 1 82  ? -14.144 -13.287 -24.372 1.00 45.10  ? 91  PRO A CG    1 
ATOM   641  C  CD    . PRO A 1 82  ? -14.218 -14.118 -25.643 1.00 44.21  ? 91  PRO A CD    1 
ATOM   642  N  N     . THR A 1 83  ? -18.216 -11.634 -25.885 1.00 37.65  ? 92  THR A N     1 
ATOM   643  C  CA    . THR A 1 83  ? -19.044 -10.696 -26.666 1.00 38.96  ? 92  THR A CA    1 
ATOM   644  C  C     . THR A 1 83  ? -18.603 -9.238  -26.448 1.00 37.54  ? 92  THR A C     1 
ATOM   645  O  O     . THR A 1 83  ? -17.868 -8.956  -25.494 1.00 36.40  ? 92  THR A O     1 
ATOM   646  C  CB    . THR A 1 83  ? -20.518 -10.807 -26.269 1.00 41.72  ? 92  THR A CB    1 
ATOM   647  O  OG1   . THR A 1 83  ? -20.668 -10.250 -24.959 1.00 46.86  ? 92  THR A OG1   1 
ATOM   648  C  CG2   . THR A 1 83  ? -21.011 -12.234 -26.327 1.00 42.24  ? 92  THR A CG2   1 
ATOM   649  N  N     . GLN A 1 84  ? -19.089 -8.354  -27.320 1.00 35.52  ? 93  GLN A N     1 
ATOM   650  C  CA    . GLN A 1 84  ? -19.090 -6.886  -27.145 1.00 42.53  ? 93  GLN A CA    1 
ATOM   651  C  C     . GLN A 1 84  ? -19.414 -6.546  -25.676 1.00 38.23  ? 93  GLN A C     1 
ATOM   652  O  O     . GLN A 1 84  ? -18.700 -5.721  -25.126 1.00 36.66  ? 93  GLN A O     1 
ATOM   653  C  CB    . GLN A 1 84  ? -20.043 -6.250  -28.158 1.00 43.92  ? 93  GLN A CB    1 
ATOM   654  C  CG    . GLN A 1 84  ? -19.324 -5.690  -29.372 1.00 56.13  ? 93  GLN A CG    1 
ATOM   655  C  CD    . GLN A 1 84  ? -20.126 -5.786  -30.648 1.00 60.64  ? 93  GLN A CD    1 
ATOM   656  O  OE1   . GLN A 1 84  ? -20.638 -4.794  -31.189 1.00 51.14  ? 93  GLN A OE1   1 
ATOM   657  N  NE2   . GLN A 1 84  ? -20.251 -7.009  -31.133 1.00 63.20  ? 93  GLN A NE2   1 
ATOM   658  N  N     . THR A 1 85  ? -20.412 -7.195  -25.054 1.00 39.94  ? 94  THR A N     1 
ATOM   659  C  CA    . THR A 1 85  ? -20.851 -6.899  -23.659 1.00 38.51  ? 94  THR A CA    1 
ATOM   660  C  C     . THR A 1 85  ? -19.719 -7.266  -22.680 1.00 38.97  ? 94  THR A C     1 
ATOM   661  O  O     . THR A 1 85  ? -19.305 -6.403  -21.914 1.00 42.54  ? 94  THR A O     1 
ATOM   662  C  CB    . THR A 1 85  ? -22.238 -7.502  -23.392 1.00 35.57  ? 94  THR A CB    1 
ATOM   663  O  OG1   . THR A 1 85  ? -23.187 -6.743  -24.139 1.00 30.52  ? 94  THR A OG1   1 
ATOM   664  C  CG2   . THR A 1 85  ? -22.643 -7.523  -21.932 1.00 33.93  ? 94  THR A CG2   1 
ATOM   665  N  N     . HIS A 1 86  ? -19.184 -8.476  -22.756 1.00 40.48  ? 95  HIS A N     1 
ATOM   666  C  CA    . HIS A 1 86  ? -18.014 -8.917  -21.952 1.00 41.19  ? 95  HIS A CA    1 
ATOM   667  C  C     . HIS A 1 86  ? -16.863 -7.885  -22.042 1.00 43.24  ? 95  HIS A C     1 
ATOM   668  O  O     . HIS A 1 86  ? -16.417 -7.374  -20.992 1.00 44.84  ? 95  HIS A O     1 
ATOM   669  C  CB    . HIS A 1 86  ? -17.553 -10.315 -22.409 1.00 43.31  ? 95  HIS A CB    1 
ATOM   670  C  CG    . HIS A 1 86  ? -18.490 -11.446 -22.118 1.00 39.72  ? 95  HIS A CG    1 
ATOM   671  N  ND1   . HIS A 1 86  ? -19.319 -11.989 -23.084 1.00 37.15  ? 95  HIS A ND1   1 
ATOM   672  C  CD2   . HIS A 1 86  ? -18.687 -12.169 -21.000 1.00 35.38  ? 95  HIS A CD2   1 
ATOM   673  C  CE1   . HIS A 1 86  ? -20.006 -12.980 -22.555 1.00 45.09  ? 95  HIS A CE1   1 
ATOM   674  N  NE2   . HIS A 1 86  ? -19.622 -13.125 -21.280 1.00 39.47  ? 95  HIS A NE2   1 
ATOM   675  N  N     . MET A 1 87  ? -16.384 -7.558  -23.242 1.00 41.08  ? 96  MET A N     1 
ATOM   676  C  CA    . MET A 1 87  ? -15.241 -6.607  -23.438 1.00 38.57  ? 96  MET A CA    1 
ATOM   677  C  C     . MET A 1 87  ? -15.586 -5.183  -22.976 1.00 34.24  ? 96  MET A C     1 
ATOM   678  O  O     . MET A 1 87  ? -14.684 -4.471  -22.375 1.00 37.29  ? 96  MET A O     1 
ATOM   679  C  CB    . MET A 1 87  ? -14.838 -6.581  -24.905 1.00 40.26  ? 96  MET A CB    1 
ATOM   680  C  CG    . MET A 1 87  ? -14.488 -7.968  -25.437 1.00 44.57  ? 96  MET A CG    1 
ATOM   681  S  SD    . MET A 1 87  ? -13.397 -8.919  -24.328 1.00 44.08  ? 96  MET A SD    1 
ATOM   682  C  CE    . MET A 1 87  ? -12.049 -7.751  -24.168 1.00 47.04  ? 96  MET A CE    1 
ATOM   683  N  N     . ALA A 1 88  ? -16.838 -4.767  -23.145 1.00 32.81  ? 97  ALA A N     1 
ATOM   684  C  CA    . ALA A 1 88  ? -17.274 -3.434  -22.682 1.00 35.89  ? 97  ALA A CA    1 
ATOM   685  C  C     . ALA A 1 88  ? -17.161 -3.382  -21.154 1.00 37.98  ? 97  ALA A C     1 
ATOM   686  O  O     . ALA A 1 88  ? -16.759 -2.321  -20.650 1.00 41.72  ? 97  ALA A O     1 
ATOM   687  C  CB    . ALA A 1 88  ? -18.668 -3.139  -23.173 1.00 39.71  ? 97  ALA A CB    1 
ATOM   688  N  N     . LEU A 1 89  ? -17.432 -4.481  -20.431 1.00 35.25  ? 98  LEU A N     1 
ATOM   689  C  CA    . LEU A 1 89  ? -17.385 -4.448  -18.936 1.00 40.01  ? 98  LEU A CA    1 
ATOM   690  C  C     . LEU A 1 89  ? -15.933 -4.387  -18.439 1.00 37.66  ? 98  LEU A C     1 
ATOM   691  O  O     . LEU A 1 89  ? -15.703 -3.823  -17.319 1.00 36.48  ? 98  LEU A O     1 
ATOM   692  C  CB    . LEU A 1 89  ? -18.110 -5.658  -18.352 1.00 36.76  ? 98  LEU A CB    1 
ATOM   693  C  CG    . LEU A 1 89  ? -19.565 -5.787  -18.750 1.00 36.26  ? 98  LEU A CG    1 
ATOM   694  C  CD1   . LEU A 1 89  ? -20.031 -7.207  -18.529 1.00 41.08  ? 98  LEU A CD1   1 
ATOM   695  C  CD2   . LEU A 1 89  ? -20.411 -4.831  -17.955 1.00 41.73  ? 98  LEU A CD2   1 
ATOM   696  N  N     . VAL A 1 90  ? -15.003 -4.974  -19.197 1.00 39.09  ? 99  VAL A N     1 
ATOM   697  C  CA    . VAL A 1 90  ? -13.534 -4.949  -18.879 1.00 37.27  ? 99  VAL A CA    1 
ATOM   698  C  C     . VAL A 1 90  ? -13.128 -3.484  -18.831 1.00 37.65  ? 99  VAL A C     1 
ATOM   699  O  O     . VAL A 1 90  ? -12.601 -3.048  -17.801 1.00 49.02  ? 99  VAL A O     1 
ATOM   700  C  CB    . VAL A 1 90  ? -12.700 -5.738  -19.903 1.00 36.60  ? 99  VAL A CB    1 
ATOM   701  C  CG1   . VAL A 1 90  ? -11.197 -5.500  -19.780 1.00 35.61  ? 99  VAL A CG1   1 
ATOM   702  C  CG2   . VAL A 1 90  ? -13.027 -7.217  -19.821 1.00 39.39  ? 99  VAL A CG2   1 
ATOM   703  N  N     . GLN A 1 91  ? -13.517 -2.742  -19.864 1.00 39.59  ? 100 GLN A N     1 
ATOM   704  C  CA    . GLN A 1 91  ? -13.205 -1.300  -20.051 1.00 36.74  ? 100 GLN A CA    1 
ATOM   705  C  C     . GLN A 1 91  ? -13.792 -0.441  -18.939 1.00 35.41  ? 100 GLN A C     1 
ATOM   706  O  O     . GLN A 1 91  ? -13.085 0.437   -18.475 1.00 38.72  ? 100 GLN A O     1 
ATOM   707  C  CB    . GLN A 1 91  ? -13.785 -0.782  -21.370 1.00 34.59  ? 100 GLN A CB    1 
ATOM   708  C  CG    . GLN A 1 91  ? -13.268 0.605   -21.740 1.00 36.83  ? 100 GLN A CG    1 
ATOM   709  C  CD    . GLN A 1 91  ? -11.785 0.590   -21.981 1.00 39.88  ? 100 GLN A CD    1 
ATOM   710  O  OE1   . GLN A 1 91  ? -11.109 -0.414  -21.773 1.00 53.59  ? 100 GLN A OE1   1 
ATOM   711  N  NE2   . GLN A 1 91  ? -11.258 1.711   -22.424 1.00 51.91  ? 100 GLN A NE2   1 
ATOM   712  N  N     . LEU A 1 92  ? -15.079 -0.603  -18.638 1.00 39.71  ? 101 LEU A N     1 
ATOM   713  C  CA    . LEU A 1 92  ? -15.768 0.103   -17.526 1.00 39.74  ? 101 LEU A CA    1 
ATOM   714  C  C     . LEU A 1 92  ? -15.043 -0.156  -16.190 1.00 42.49  ? 101 LEU A C     1 
ATOM   715  O  O     . LEU A 1 92  ? -15.076 0.755   -15.318 1.00 42.07  ? 101 LEU A O     1 
ATOM   716  C  CB    . LEU A 1 92  ? -17.235 -0.344  -17.467 1.00 45.37  ? 101 LEU A CB    1 
ATOM   717  C  CG    . LEU A 1 92  ? -18.077 -0.028  -18.706 1.00 40.08  ? 101 LEU A CG    1 
ATOM   718  C  CD1   . LEU A 1 92  ? -19.458 -0.633  -18.581 1.00 44.80  ? 101 LEU A CD1   1 
ATOM   719  C  CD2   . LEU A 1 92  ? -18.178 1.468   -18.915 1.00 44.10  ? 101 LEU A CD2   1 
ATOM   720  N  N     . GLU A 1 93  ? -14.400 -1.315  -15.998 1.00 45.12  ? 102 GLU A N     1 
ATOM   721  C  CA    . GLU A 1 93  ? -13.610 -1.578  -14.752 1.00 47.02  ? 102 GLU A CA    1 
ATOM   722  C  C     . GLU A 1 93  ? -12.312 -0.776  -14.892 1.00 47.91  ? 102 GLU A C     1 
ATOM   723  O  O     . GLU A 1 93  ? -11.852 -0.178  -13.899 1.00 35.89  ? 102 GLU A O     1 
ATOM   724  C  CB    . GLU A 1 93  ? -13.312 -3.071  -14.543 1.00 47.14  ? 102 GLU A CB    1 
ATOM   725  C  CG    . GLU A 1 93  ? -12.536 -3.422  -13.273 1.00 47.57  ? 102 GLU A CG    1 
ATOM   726  C  CD    . GLU A 1 93  ? -11.084 -2.963  -13.118 1.00 49.18  ? 102 GLU A CD    1 
ATOM   727  O  OE1   . GLU A 1 93  ? -10.315 -3.065  -14.076 1.00 50.02  ? 102 GLU A OE1   1 
ATOM   728  O  OE2   . GLU A 1 93  ? -10.711 -2.528  -12.005 1.00 50.04  ? 102 GLU A OE2   1 
ATOM   729  N  N     . ARG A 1 94  ? -11.777 -0.707  -16.110 1.00 40.59  ? 103 ARG A N     1 
ATOM   730  C  CA    . ARG A 1 94  ? -10.413 -0.163  -16.304 1.00 43.42  ? 103 ARG A CA    1 
ATOM   731  C  C     . ARG A 1 94  ? -10.445 1.363   -16.185 1.00 44.13  ? 103 ARG A C     1 
ATOM   732  O  O     . ARG A 1 94  ? -9.378  1.930   -15.897 1.00 55.12  ? 103 ARG A O     1 
ATOM   733  C  CB    . ARG A 1 94  ? -9.831  -0.635  -17.632 1.00 51.10  ? 103 ARG A CB    1 
ATOM   734  C  CG    . ARG A 1 94  ? -9.086  -1.963  -17.583 1.00 51.37  ? 103 ARG A CG    1 
ATOM   735  C  CD    . ARG A 1 94  ? -8.117  -1.977  -18.762 1.00 56.37  ? 103 ARG A CD    1 
ATOM   736  N  NE    . ARG A 1 94  ? -8.054  -3.232  -19.509 1.00 57.53  ? 103 ARG A NE    1 
ATOM   737  C  CZ    . ARG A 1 94  ? -7.910  -3.342  -20.832 1.00 59.71  ? 103 ARG A CZ    1 
ATOM   738  N  NH1   . ARG A 1 94  ? -7.860  -4.549  -21.365 1.00 57.33  ? 103 ARG A NH1   1 
ATOM   739  N  NH2   . ARG A 1 94  ? -7.879  -2.274  -21.627 1.00 63.35  ? 103 ARG A NH2   1 
ATOM   740  N  N     . VAL A 1 95  ? -11.603 2.004   -16.382 1.00 41.56  ? 104 VAL A N     1 
ATOM   741  C  CA    . VAL A 1 95  ? -11.750 3.476   -16.238 1.00 41.50  ? 104 VAL A CA    1 
ATOM   742  C  C     . VAL A 1 95  ? -12.501 3.828   -14.944 1.00 39.93  ? 104 VAL A C     1 
ATOM   743  O  O     . VAL A 1 95  ? -12.827 5.016   -14.787 1.00 43.56  ? 104 VAL A O     1 
ATOM   744  C  CB    . VAL A 1 95  ? -12.426 4.119   -17.465 1.00 42.46  ? 104 VAL A CB    1 
ATOM   745  C  CG1   . VAL A 1 95  ? -11.725 3.735   -18.761 1.00 47.21  ? 104 VAL A CG1   1 
ATOM   746  C  CG2   . VAL A 1 95  ? -13.915 3.837   -17.526 1.00 44.44  ? 104 VAL A CG2   1 
ATOM   747  N  N     . GLY A 1 96  ? -12.756 2.868   -14.061 1.00 39.48  ? 105 GLY A N     1 
ATOM   748  C  CA    . GLY A 1 96  ? -13.351 3.108   -12.734 1.00 39.90  ? 105 GLY A CA    1 
ATOM   749  C  C     . GLY A 1 96  ? -14.862 3.323   -12.742 1.00 42.34  ? 105 GLY A C     1 
ATOM   750  O  O     . GLY A 1 96  ? -15.390 3.782   -11.684 1.00 35.88  ? 105 GLY A O     1 
ATOM   751  N  N     . LEU A 1 97  ? -15.580 2.980   -13.827 1.00 40.87  ? 106 LEU A N     1 
ATOM   752  C  CA    . LEU A 1 97  ? -17.055 3.211   -13.876 1.00 44.03  ? 106 LEU A CA    1 
ATOM   753  C  C     . LEU A 1 97  ? -17.814 1.979   -13.367 1.00 39.15  ? 106 LEU A C     1 
ATOM   754  O  O     . LEU A 1 97  ? -19.025 2.054   -13.261 1.00 47.05  ? 106 LEU A O     1 
ATOM   755  C  CB    . LEU A 1 97  ? -17.507 3.627   -15.284 1.00 45.48  ? 106 LEU A CB    1 
ATOM   756  C  CG    . LEU A 1 97  ? -17.035 5.018   -15.740 1.00 51.55  ? 106 LEU A CG    1 
ATOM   757  C  CD1   . LEU A 1 97  ? -17.389 5.281   -17.210 1.00 48.50  ? 106 LEU A CD1   1 
ATOM   758  C  CD2   . LEU A 1 97  ? -17.604 6.122   -14.848 1.00 48.07  ? 106 LEU A CD2   1 
ATOM   759  N  N     . LEU A 1 98  ? -17.123 0.905   -13.016 1.00 45.70  ? 107 LEU A N     1 
ATOM   760  C  CA    . LEU A 1 98  ? -17.729 -0.366  -12.547 1.00 42.04  ? 107 LEU A CA    1 
ATOM   761  C  C     . LEU A 1 98  ? -16.983 -0.753  -11.265 1.00 40.65  ? 107 LEU A C     1 
ATOM   762  O  O     . LEU A 1 98  ? -15.812 -1.042  -11.389 1.00 37.90  ? 107 LEU A O     1 
ATOM   763  C  CB    . LEU A 1 98  ? -17.565 -1.377  -13.693 1.00 38.54  ? 107 LEU A CB    1 
ATOM   764  C  CG    . LEU A 1 98  ? -18.182 -2.764  -13.506 1.00 43.55  ? 107 LEU A CG    1 
ATOM   765  C  CD1   . LEU A 1 98  ? -18.231 -3.518  -14.824 1.00 46.52  ? 107 LEU A CD1   1 
ATOM   766  C  CD2   . LEU A 1 98  ? -17.412 -3.596  -12.480 1.00 46.35  ? 107 LEU A CD2   1 
ATOM   767  N  N     . ARG A 1 99  ? -17.617 -0.720  -10.084 1.00 41.39  ? 108 ARG A N     1 
ATOM   768  C  CA    . ARG A 1 99  ? -16.981 -1.089  -8.781  1.00 40.63  ? 108 ARG A CA    1 
ATOM   769  C  C     . ARG A 1 99  ? -16.804 -2.616  -8.696  1.00 39.88  ? 108 ARG A C     1 
ATOM   770  O  O     . ARG A 1 99  ? -15.724 -3.091  -8.401  1.00 41.11  ? 108 ARG A O     1 
ATOM   771  C  CB    . ARG A 1 99  ? -17.831 -0.584  -7.605  1.00 50.25  ? 108 ARG A CB    1 
ATOM   772  C  CG    . ARG A 1 99  ? -17.329 -0.990  -6.219  1.00 54.34  ? 108 ARG A CG    1 
ATOM   773  C  CD    . ARG A 1 99  ? -16.204 -0.177  -5.581  1.00 54.96  ? 108 ARG A CD    1 
ATOM   774  N  NE    . ARG A 1 99  ? -15.940 -0.678  -4.215  1.00 68.84  ? 108 ARG A NE    1 
ATOM   775  C  CZ    . ARG A 1 99  ? -15.168 -0.106  -3.270  1.00 69.88  ? 108 ARG A CZ    1 
ATOM   776  N  NH1   . ARG A 1 99  ? -14.533 1.035   -3.485  1.00 78.15  ? 108 ARG A NH1   1 
ATOM   777  N  NH2   . ARG A 1 99  ? -15.040 -0.679  -2.087  1.00 71.69  ? 108 ARG A NH2   1 
ATOM   778  N  N     . PHE A 1 100 ? -17.849 -3.368  -8.986  1.00 39.07  ? 109 PHE A N     1 
ATOM   779  C  CA    . PHE A 1 100 ? -17.897 -4.830  -8.808  1.00 37.67  ? 109 PHE A CA    1 
ATOM   780  C  C     . PHE A 1 100 ? -18.716 -5.481  -9.902  1.00 37.54  ? 109 PHE A C     1 
ATOM   781  O  O     . PHE A 1 100 ? -19.616 -4.867  -10.479 1.00 37.00  ? 109 PHE A O     1 
ATOM   782  C  CB    . PHE A 1 100 ? -18.579 -5.256  -7.502  1.00 37.43  ? 109 PHE A CB    1 
ATOM   783  C  CG    . PHE A 1 100 ? -18.042 -6.565  -6.986  1.00 33.42  ? 109 PHE A CG    1 
ATOM   784  C  CD1   . PHE A 1 100 ? -16.713 -6.668  -6.571  1.00 36.73  ? 109 PHE A CD1   1 
ATOM   785  C  CD2   . PHE A 1 100 ? -18.817 -7.700  -6.994  1.00 32.26  ? 109 PHE A CD2   1 
ATOM   786  C  CE1   . PHE A 1 100 ? -16.180 -7.883  -6.174  1.00 35.20  ? 109 PHE A CE1   1 
ATOM   787  C  CE2   . PHE A 1 100 ? -18.299 -8.910  -6.547  1.00 36.16  ? 109 PHE A CE2   1 
ATOM   788  C  CZ    . PHE A 1 100 ? -16.986 -8.999  -6.125  1.00 33.19  ? 109 PHE A CZ    1 
ATOM   789  N  N     . LEU A 1 101 ? -18.466 -6.767  -10.085 1.00 36.07  ? 110 LEU A N     1 
ATOM   790  C  CA    . LEU A 1 101 ? -19.191 -7.548  -11.094 1.00 37.99  ? 110 LEU A CA    1 
ATOM   791  C  C     . LEU A 1 101 ? -19.596 -8.849  -10.428 1.00 39.01  ? 110 LEU A C     1 
ATOM   792  O  O     . LEU A 1 101 ? -18.722 -9.508  -9.790  1.00 39.81  ? 110 LEU A O     1 
ATOM   793  C  CB    . LEU A 1 101 ? -18.318 -7.753  -12.345 1.00 33.88  ? 110 LEU A CB    1 
ATOM   794  C  CG    . LEU A 1 101 ? -18.912 -8.682  -13.392 1.00 34.91  ? 110 LEU A CG    1 
ATOM   795  C  CD1   . LEU A 1 101 ? -20.332 -8.253  -13.719 1.00 35.51  ? 110 LEU A CD1   1 
ATOM   796  C  CD2   . LEU A 1 101 ? -18.049 -8.710  -14.665 1.00 40.03  ? 110 LEU A CD2   1 
ATOM   797  N  N     . VAL A 1 102 ? -20.884 -9.146  -10.555 1.00 39.75  ? 111 VAL A N     1 
ATOM   798  C  CA    . VAL A 1 102 ? -21.556 -10.339 -9.967  1.00 43.68  ? 111 VAL A CA    1 
ATOM   799  C  C     . VAL A 1 102 ? -22.220 -11.078 -11.116 1.00 40.94  ? 111 VAL A C     1 
ATOM   800  O  O     . VAL A 1 102 ? -23.103 -10.497 -11.702 1.00 41.41  ? 111 VAL A O     1 
ATOM   801  C  CB    . VAL A 1 102 ? -22.593 -9.925  -8.914  1.00 40.99  ? 111 VAL A CB    1 
ATOM   802  C  CG1   . VAL A 1 102 ? -23.367 -11.121 -8.413  1.00 41.73  ? 111 VAL A CG1   1 
ATOM   803  C  CG2   . VAL A 1 102 ? -21.911 -9.170  -7.786  1.00 45.97  ? 111 VAL A CG2   1 
ATOM   804  N  N     . SER A 1 103 ? -21.726 -12.269 -11.439 1.00 41.45  ? 112 SER A N     1 
ATOM   805  C  CA    . SER A 1 103 ? -22.229 -13.108 -12.542 1.00 38.24  ? 112 SER A CA    1 
ATOM   806  C  C     . SER A 1 103 ? -22.681 -14.447 -11.988 1.00 35.39  ? 112 SER A C     1 
ATOM   807  O  O     . SER A 1 103 ? -22.035 -14.923 -11.070 1.00 36.38  ? 112 SER A O     1 
ATOM   808  C  CB    . SER A 1 103 ? -21.239 -13.309 -13.633 1.00 38.90  ? 112 SER A CB    1 
ATOM   809  O  OG    . SER A 1 103 ? -21.921 -13.702 -14.831 1.00 43.69  ? 112 SER A OG    1 
ATOM   810  N  N     . GLN A 1 104 ? -23.724 -15.004 -12.610 1.00 36.24  ? 113 GLN A N     1 
ATOM   811  C  CA    . GLN A 1 104 ? -24.263 -16.357 -12.370 1.00 38.23  ? 113 GLN A CA    1 
ATOM   812  C  C     . GLN A 1 104 ? -23.777 -17.348 -13.426 1.00 39.54  ? 113 GLN A C     1 
ATOM   813  O  O     . GLN A 1 104 ? -24.042 -18.553 -13.219 1.00 41.13  ? 113 GLN A O     1 
ATOM   814  C  CB    . GLN A 1 104 ? -25.779 -16.312 -12.377 1.00 43.71  ? 113 GLN A CB    1 
ATOM   815  C  CG    . GLN A 1 104 ? -26.311 -15.531 -11.195 1.00 41.74  ? 113 GLN A CG    1 
ATOM   816  C  CD    . GLN A 1 104 ? -27.809 -15.446 -11.182 1.00 41.92  ? 113 GLN A CD    1 
ATOM   817  O  OE1   . GLN A 1 104 ? -28.521 -16.442 -11.051 1.00 40.10  ? 113 GLN A OE1   1 
ATOM   818  N  NE2   . GLN A 1 104 ? -28.295 -14.220 -11.215 1.00 55.67  ? 113 GLN A NE2   1 
ATOM   819  N  N     . ASN A 1 105 ? -23.070 -16.895 -14.467 1.00 38.11  ? 114 ASN A N     1 
ATOM   820  C  CA    . ASN A 1 105 ? -22.592 -17.790 -15.563 1.00 38.15  ? 114 ASN A CA    1 
ATOM   821  C  C     . ASN A 1 105 ? -21.418 -18.634 -15.070 1.00 35.59  ? 114 ASN A C     1 
ATOM   822  O  O     . ASN A 1 105 ? -20.546 -18.077 -14.376 1.00 40.47  ? 114 ASN A O     1 
ATOM   823  C  CB    . ASN A 1 105 ? -22.121 -17.018 -16.805 1.00 40.32  ? 114 ASN A CB    1 
ATOM   824  C  CG    . ASN A 1 105 ? -23.112 -15.939 -17.123 1.00 37.26  ? 114 ASN A CG    1 
ATOM   825  O  OD1   . ASN A 1 105 ? -24.187 -15.955 -16.550 1.00 41.46  ? 114 ASN A OD1   1 
ATOM   826  N  ND2   . ASN A 1 105 ? -22.766 -14.996 -17.974 1.00 41.09  ? 114 ASN A ND2   1 
ATOM   827  N  N     . VAL A 1 106 ? -21.373 -19.890 -15.497 1.00 32.83  ? 115 VAL A N     1 
ATOM   828  C  CA    . VAL A 1 106 ? -20.250 -20.849 -15.303 1.00 33.66  ? 115 VAL A CA    1 
ATOM   829  C  C     . VAL A 1 106 ? -19.399 -20.988 -16.590 1.00 37.17  ? 115 VAL A C     1 
ATOM   830  O  O     . VAL A 1 106 ? -18.466 -21.798 -16.596 1.00 41.67  ? 115 VAL A O     1 
ATOM   831  C  CB    . VAL A 1 106 ? -20.825 -22.200 -14.865 1.00 37.51  ? 115 VAL A CB    1 
ATOM   832  C  CG1   . VAL A 1 106 ? -21.504 -22.129 -13.486 1.00 38.19  ? 115 VAL A CG1   1 
ATOM   833  C  CG2   . VAL A 1 106 ? -21.781 -22.733 -15.903 1.00 35.90  ? 115 VAL A CG2   1 
ATOM   834  N  N     . ASP A 1 107 ? -19.663 -20.204 -17.641 1.00 40.80  ? 116 ASP A N     1 
ATOM   835  C  CA    . ASP A 1 107 ? -18.996 -20.322 -18.975 1.00 41.37  ? 116 ASP A CA    1 
ATOM   836  C  C     . ASP A 1 107 ? -17.536 -19.826 -18.963 1.00 35.24  ? 116 ASP A C     1 
ATOM   837  O  O     . ASP A 1 107 ? -16.832 -20.096 -19.927 1.00 43.57  ? 116 ASP A O     1 
ATOM   838  C  CB    . ASP A 1 107 ? -19.827 -19.630 -20.068 1.00 44.99  ? 116 ASP A CB    1 
ATOM   839  C  CG    . ASP A 1 107 ? -19.994 -18.120 -19.927 1.00 43.07  ? 116 ASP A CG    1 
ATOM   840  O  OD1   . ASP A 1 107 ? -19.050 -17.472 -19.462 1.00 47.24  ? 116 ASP A OD1   1 
ATOM   841  O  OD2   . ASP A 1 107 ? -21.085 -17.620 -20.248 1.00 38.31  ? 116 ASP A OD2   1 
ATOM   842  N  N     . GLY A 1 108 ? -17.074 -19.153 -17.922 1.00 36.60  ? 117 GLY A N     1 
ATOM   843  C  CA    . GLY A 1 108 ? -15.673 -18.694 -17.758 1.00 34.90  ? 117 GLY A CA    1 
ATOM   844  C  C     . GLY A 1 108 ? -15.287 -17.480 -18.610 1.00 33.47  ? 117 GLY A C     1 
ATOM   845  O  O     . GLY A 1 108 ? -14.167 -17.047 -18.513 1.00 40.79  ? 117 GLY A O     1 
ATOM   846  N  N     . LEU A 1 109 ? -16.163 -16.947 -19.454 1.00 37.56  ? 118 LEU A N     1 
ATOM   847  C  CA    . LEU A 1 109 ? -15.799 -15.936 -20.481 1.00 36.39  ? 118 LEU A CA    1 
ATOM   848  C  C     . LEU A 1 109 ? -15.434 -14.606 -19.815 1.00 39.79  ? 118 LEU A C     1 
ATOM   849  O  O     . LEU A 1 109 ? -14.585 -13.886 -20.350 1.00 36.21  ? 118 LEU A O     1 
ATOM   850  C  CB    . LEU A 1 109 ? -16.984 -15.733 -21.414 1.00 36.15  ? 118 LEU A CB    1 
ATOM   851  C  CG    . LEU A 1 109 ? -17.222 -16.818 -22.454 1.00 36.38  ? 118 LEU A CG    1 
ATOM   852  C  CD1   . LEU A 1 109 ? -18.546 -16.584 -23.146 1.00 41.57  ? 118 LEU A CD1   1 
ATOM   853  C  CD2   . LEU A 1 109 ? -16.101 -16.888 -23.470 1.00 39.43  ? 118 LEU A CD2   1 
ATOM   854  N  N     . HIS A 1 110 ? -16.050 -14.276 -18.686 1.00 39.26  ? 119 HIS A N     1 
ATOM   855  C  CA    . HIS A 1 110 ? -15.599 -13.122 -17.878 1.00 37.18  ? 119 HIS A CA    1 
ATOM   856  C  C     . HIS A 1 110 ? -14.115 -13.278 -17.588 1.00 39.43  ? 119 HIS A C     1 
ATOM   857  O  O     . HIS A 1 110 ? -13.354 -12.367 -17.944 1.00 40.24  ? 119 HIS A O     1 
ATOM   858  C  CB    . HIS A 1 110 ? -16.384 -12.938 -16.594 1.00 35.22  ? 119 HIS A CB    1 
ATOM   859  C  CG    . HIS A 1 110 ? -17.652 -12.211 -16.834 1.00 37.40  ? 119 HIS A CG    1 
ATOM   860  N  ND1   . HIS A 1 110 ? -17.765 -11.256 -17.806 1.00 41.74  ? 119 HIS A ND1   1 
ATOM   861  C  CD2   . HIS A 1 110 ? -18.865 -12.301 -16.245 1.00 42.98  ? 119 HIS A CD2   1 
ATOM   862  C  CE1   . HIS A 1 110 ? -18.986 -10.773 -17.797 1.00 37.79  ? 119 HIS A CE1   1 
ATOM   863  N  NE2   . HIS A 1 110 ? -19.691 -11.416 -16.867 1.00 39.11  ? 119 HIS A NE2   1 
ATOM   864  N  N     . VAL A 1 111 ? -13.707 -14.374 -16.963 1.00 36.50  ? 120 VAL A N     1 
ATOM   865  C  CA    . VAL A 1 111 ? -12.276 -14.523 -16.599 1.00 33.84  ? 120 VAL A CA    1 
ATOM   866  C  C     . VAL A 1 111 ? -11.456 -14.517 -17.890 1.00 41.16  ? 120 VAL A C     1 
ATOM   867  O  O     . VAL A 1 111 ? -10.457 -13.769 -17.948 1.00 43.12  ? 120 VAL A O     1 
ATOM   868  C  CB    . VAL A 1 111 ? -12.008 -15.772 -15.755 1.00 36.14  ? 120 VAL A CB    1 
ATOM   869  C  CG1   . VAL A 1 111 ? -10.518 -16.111 -15.777 1.00 31.52  ? 120 VAL A CG1   1 
ATOM   870  C  CG2   . VAL A 1 111 ? -12.520 -15.597 -14.329 1.00 36.74  ? 120 VAL A CG2   1 
ATOM   871  N  N     . ARG A 1 112 ? -11.862 -15.294 -18.901 1.00 39.63  ? 121 ARG A N     1 
ATOM   872  C  CA    . ARG A 1 112 ? -11.100 -15.382 -20.174 1.00 35.88  ? 121 ARG A CA    1 
ATOM   873  C  C     . ARG A 1 112 ? -10.969 -14.020 -20.876 1.00 33.46  ? 121 ARG A C     1 
ATOM   874  O  O     . ARG A 1 112 ? -10.023 -13.886 -21.630 1.00 36.60  ? 121 ARG A O     1 
ATOM   875  C  CB    . ARG A 1 112 ? -11.683 -16.461 -21.081 1.00 36.80  ? 121 ARG A CB    1 
ATOM   876  C  CG    . ARG A 1 112 ? -11.294 -17.864 -20.625 1.00 41.75  ? 121 ARG A CG    1 
ATOM   877  C  CD    . ARG A 1 112 ? -12.175 -19.016 -21.071 1.00 40.00  ? 121 ARG A CD    1 
ATOM   878  N  NE    . ARG A 1 112 ? -11.806 -19.557 -22.375 1.00 43.54  ? 121 ARG A NE    1 
ATOM   879  C  CZ    . ARG A 1 112 ? -10.789 -20.391 -22.602 1.00 46.64  ? 121 ARG A CZ    1 
ATOM   880  N  NH1   . ARG A 1 112 ? -9.992  -20.787 -21.626 1.00 48.17  ? 121 ARG A NH1   1 
ATOM   881  N  NH2   . ARG A 1 112 ? -10.598 -20.869 -23.816 1.00 44.40  ? 121 ARG A NH2   1 
ATOM   882  N  N     . SER A 1 113 ? -11.834 -13.042 -20.629 1.00 34.79  ? 122 SER A N     1 
ATOM   883  C  CA    . SER A 1 113 ? -11.804 -11.694 -21.272 1.00 36.22  ? 122 SER A CA    1 
ATOM   884  C  C     . SER A 1 113 ? -10.757 -10.791 -20.594 1.00 34.67  ? 122 SER A C     1 
ATOM   885  O  O     . SER A 1 113 ? -10.505 -9.657  -21.066 1.00 35.53  ? 122 SER A O     1 
ATOM   886  C  CB    . SER A 1 113 ? -13.199 -11.074 -21.179 1.00 36.17  ? 122 SER A CB    1 
ATOM   887  O  OG    . SER A 1 113 ? -13.541 -10.845 -19.797 1.00 36.58  ? 122 SER A OG    1 
ATOM   888  N  N     . GLY A 1 114 ? -10.213 -11.226 -19.459 1.00 37.04  ? 123 GLY A N     1 
ATOM   889  C  CA    . GLY A 1 114 ? -9.220  -10.444 -18.707 1.00 37.09  ? 123 GLY A CA    1 
ATOM   890  C  C     . GLY A 1 114 ? -9.880  -9.613  -17.629 1.00 34.87  ? 123 GLY A C     1 
ATOM   891  O  O     . GLY A 1 114 ? -9.239  -8.737  -17.078 1.00 37.40  ? 123 GLY A O     1 
ATOM   892  N  N     . PHE A 1 115 ? -11.082 -9.952  -17.230 1.00 38.57  ? 124 PHE A N     1 
ATOM   893  C  CA    . PHE A 1 115 ? -11.709 -9.254  -16.094 1.00 42.74  ? 124 PHE A CA    1 
ATOM   894  C  C     . PHE A 1 115 ? -10.977 -9.665  -14.828 1.00 40.33  ? 124 PHE A C     1 
ATOM   895  O  O     . PHE A 1 115 ? -10.775 -10.846 -14.627 1.00 44.31  ? 124 PHE A O     1 
ATOM   896  C  CB    . PHE A 1 115 ? -13.197 -9.552  -15.977 1.00 38.32  ? 124 PHE A CB    1 
ATOM   897  C  CG    . PHE A 1 115 ? -13.917 -8.467  -15.228 1.00 36.90  ? 124 PHE A CG    1 
ATOM   898  C  CD1   . PHE A 1 115 ? -14.427 -7.369  -15.895 1.00 40.41  ? 124 PHE A CD1   1 
ATOM   899  C  CD2   . PHE A 1 115 ? -14.056 -8.537  -13.845 1.00 41.62  ? 124 PHE A CD2   1 
ATOM   900  C  CE1   . PHE A 1 115 ? -15.112 -6.379  -15.197 1.00 41.21  ? 124 PHE A CE1   1 
ATOM   901  C  CE2   . PHE A 1 115 ? -14.717 -7.538  -13.146 1.00 38.57  ? 124 PHE A CE2   1 
ATOM   902  C  CZ    . PHE A 1 115 ? -15.260 -6.471  -13.830 1.00 37.24  ? 124 PHE A CZ    1 
ATOM   903  N  N     . PRO A 1 116 ? -10.533 -8.712  -13.978 1.00 43.55  ? 125 PRO A N     1 
ATOM   904  C  CA    . PRO A 1 116 ? -9.790  -9.041  -12.756 1.00 45.21  ? 125 PRO A CA    1 
ATOM   905  C  C     . PRO A 1 116 ? -10.610 -9.809  -11.720 1.00 42.05  ? 125 PRO A C     1 
ATOM   906  O  O     . PRO A 1 116 ? -11.609 -9.302  -11.305 1.00 41.85  ? 125 PRO A O     1 
ATOM   907  C  CB    . PRO A 1 116 ? -9.419  -7.682  -12.167 1.00 46.79  ? 125 PRO A CB    1 
ATOM   908  C  CG    . PRO A 1 116 ? -10.470 -6.741  -12.735 1.00 45.10  ? 125 PRO A CG    1 
ATOM   909  C  CD    . PRO A 1 116 ? -10.726 -7.264  -14.133 1.00 41.35  ? 125 PRO A CD    1 
ATOM   910  N  N     . ARG A 1 117 ? -10.135 -10.995 -11.333 1.00 44.41  ? 126 ARG A N     1 
ATOM   911  C  CA    . ARG A 1 117 ? -10.861 -11.968 -10.471 1.00 42.90  ? 126 ARG A CA    1 
ATOM   912  C  C     . ARG A 1 117 ? -11.240 -11.379 -9.096  1.00 43.53  ? 126 ARG A C     1 
ATOM   913  O  O     . ARG A 1 117 ? -12.266 -11.819 -8.552  1.00 50.58  ? 126 ARG A O     1 
ATOM   914  C  CB    . ARG A 1 117 ? -10.000 -13.224 -10.357 1.00 41.29  ? 126 ARG A CB    1 
ATOM   915  C  CG    . ARG A 1 117 ? -9.884  -13.979 -11.675 1.00 44.47  ? 126 ARG A CG    1 
ATOM   916  C  CD    . ARG A 1 117 ? -9.343  -15.387 -11.518 1.00 45.05  ? 126 ARG A CD    1 
ATOM   917  N  NE    . ARG A 1 117 ? -10.234 -16.223 -10.732 1.00 44.44  ? 126 ARG A NE    1 
ATOM   918  C  CZ    . ARG A 1 117 ? -9.840  -17.093 -9.819  1.00 49.73  ? 126 ARG A CZ    1 
ATOM   919  N  NH1   . ARG A 1 117 ? -8.553  -17.228 -9.538  1.00 48.31  ? 126 ARG A NH1   1 
ATOM   920  N  NH2   . ARG A 1 117 ? -10.737 -17.811 -9.170  1.00 52.59  ? 126 ARG A NH2   1 
ATOM   921  N  N     . ASP A 1 118 ? -10.457 -10.445 -8.547  1.00 42.82  ? 127 ASP A N     1 
ATOM   922  C  CA    . ASP A 1 118 ? -10.714 -9.789  -7.235  1.00 47.27  ? 127 ASP A CA    1 
ATOM   923  C  C     . ASP A 1 118 ? -11.896 -8.793  -7.334  1.00 47.41  ? 127 ASP A C     1 
ATOM   924  O  O     . ASP A 1 118 ? -12.269 -8.306  -6.283  1.00 40.17  ? 127 ASP A O     1 
ATOM   925  C  CB    . ASP A 1 118 ? -9.439  -9.135  -6.667  1.00 47.58  ? 127 ASP A CB    1 
ATOM   926  C  CG    . ASP A 1 118 ? -8.886  -7.948  -7.473  1.00 54.92  ? 127 ASP A CG    1 
ATOM   927  O  OD1   . ASP A 1 118 ? -9.016  -7.953  -8.718  1.00 50.83  ? 127 ASP A OD1   1 
ATOM   928  O  OD2   . ASP A 1 118 ? -8.334  -7.010  -6.857  1.00 42.29  ? 127 ASP A OD2   1 
ATOM   929  N  N     . LYS A 1 119 ? -12.445 -8.461  -8.522  1.00 44.56  ? 128 LYS A N     1 
ATOM   930  C  CA    . LYS A 1 119 ? -13.611 -7.536  -8.616  1.00 44.84  ? 128 LYS A CA    1 
ATOM   931  C  C     . LYS A 1 119 ? -14.804 -8.248  -9.236  1.00 45.23  ? 128 LYS A C     1 
ATOM   932  O  O     . LYS A 1 119 ? -15.725 -7.558  -9.645  1.00 42.98  ? 128 LYS A O     1 
ATOM   933  C  CB    . LYS A 1 119 ? -13.299 -6.258  -9.386  1.00 50.79  ? 128 LYS A CB    1 
ATOM   934  C  CG    . LYS A 1 119 ? -12.489 -5.233  -8.614  1.00 52.05  ? 128 LYS A CG    1 
ATOM   935  C  CD    . LYS A 1 119 ? -12.200 -4.005  -9.423  1.00 55.84  ? 128 LYS A CD    1 
ATOM   936  C  CE    . LYS A 1 119 ? -11.594 -2.900  -8.584  1.00 59.10  ? 128 LYS A CE    1 
ATOM   937  N  NZ    . LYS A 1 119 ? -11.541 -1.634  -9.336  1.00 53.20  ? 128 LYS A NZ    1 
ATOM   938  N  N     . LEU A 1 120 ? -14.842 -9.573  -9.149  1.00 43.01  ? 129 LEU A N     1 
ATOM   939  C  CA    . LEU A 1 120 ? -15.898 -10.383 -9.788  1.00 46.06  ? 129 LEU A CA    1 
ATOM   940  C  C     . LEU A 1 120 ? -16.319 -11.502 -8.845  1.00 41.16  ? 129 LEU A C     1 
ATOM   941  O  O     . LEU A 1 120 ? -15.442 -12.146 -8.329  1.00 39.82  ? 129 LEU A O     1 
ATOM   942  C  CB    . LEU A 1 120 ? -15.282 -10.942 -11.071 1.00 46.71  ? 129 LEU A CB    1 
ATOM   943  C  CG    . LEU A 1 120 ? -15.805 -12.282 -11.531 1.00 44.09  ? 129 LEU A CG    1 
ATOM   944  C  CD1   . LEU A 1 120 ? -17.239 -12.135 -12.035 1.00 49.38  ? 129 LEU A CD1   1 
ATOM   945  C  CD2   . LEU A 1 120 ? -14.898 -12.843 -12.599 1.00 45.41  ? 129 LEU A CD2   1 
ATOM   946  N  N     . ALA A 1 121 ? -17.602 -11.771 -8.676  1.00 41.23  ? 130 ALA A N     1 
ATOM   947  C  CA    . ALA A 1 121 ? -18.073 -12.905 -7.831  1.00 48.98  ? 130 ALA A CA    1 
ATOM   948  C  C     . ALA A 1 121 ? -18.771 -13.951 -8.701  1.00 45.32  ? 130 ALA A C     1 
ATOM   949  O  O     . ALA A 1 121 ? -19.860 -13.643 -9.212  1.00 41.74  ? 130 ALA A O     1 
ATOM   950  C  CB    . ALA A 1 121 ? -18.991 -12.442 -6.735  1.00 44.38  ? 130 ALA A CB    1 
ATOM   951  N  N     . GLU A 1 122 ? -18.162 -15.132 -8.828  1.00 43.75  ? 131 GLU A N     1 
ATOM   952  C  CA    . GLU A 1 122 ? -18.666 -16.248 -9.669  1.00 47.22  ? 131 GLU A CA    1 
ATOM   953  C  C     . GLU A 1 122 ? -19.610 -17.082 -8.815  1.00 43.43  ? 131 GLU A C     1 
ATOM   954  O  O     . GLU A 1 122 ? -19.157 -18.072 -8.203  1.00 49.76  ? 131 GLU A O     1 
ATOM   955  C  CB    . GLU A 1 122 ? -17.483 -17.018 -10.259 1.00 48.95  ? 131 GLU A CB    1 
ATOM   956  C  CG    . GLU A 1 122 ? -16.611 -16.115 -11.123 1.00 48.77  ? 131 GLU A CG    1 
ATOM   957  C  CD    . GLU A 1 122 ? -15.869 -16.781 -12.267 1.00 46.39  ? 131 GLU A CD    1 
ATOM   958  O  OE1   . GLU A 1 122 ? -14.777 -17.298 -12.042 1.00 46.33  ? 131 GLU A OE1   1 
ATOM   959  O  OE2   . GLU A 1 122 ? -16.361 -16.743 -13.386 1.00 49.74  ? 131 GLU A OE2   1 
ATOM   960  N  N     . LEU A 1 123 ? -20.857 -16.636 -8.738  1.00 41.81  ? 132 LEU A N     1 
ATOM   961  C  CA    . LEU A 1 123 ? -21.865 -17.163 -7.801  1.00 43.76  ? 132 LEU A CA    1 
ATOM   962  C  C     . LEU A 1 123 ? -22.115 -18.659 -8.035  1.00 46.95  ? 132 LEU A C     1 
ATOM   963  O  O     . LEU A 1 123 ? -22.282 -19.386 -7.034  1.00 46.74  ? 132 LEU A O     1 
ATOM   964  C  CB    . LEU A 1 123 ? -23.136 -16.327 -7.983  1.00 46.17  ? 132 LEU A CB    1 
ATOM   965  C  CG    . LEU A 1 123 ? -23.043 -14.890 -7.459  1.00 45.81  ? 132 LEU A CG    1 
ATOM   966  C  CD1   . LEU A 1 123 ? -24.416 -14.271 -7.310  1.00 51.84  ? 132 LEU A CD1   1 
ATOM   967  C  CD2   . LEU A 1 123 ? -22.347 -14.831 -6.121  1.00 43.15  ? 132 LEU A CD2   1 
ATOM   968  N  N     . HIS A 1 124 ? -22.185 -19.122 -9.291  1.00 46.51  ? 133 HIS A N     1 
ATOM   969  C  CA    . HIS A 1 124 ? -22.556 -20.532 -9.570  1.00 40.58  ? 133 HIS A CA    1 
ATOM   970  C  C     . HIS A 1 124 ? -21.324 -21.339 -9.939  1.00 36.77  ? 133 HIS A C     1 
ATOM   971  O  O     . HIS A 1 124 ? -21.492 -22.543 -10.248 1.00 40.96  ? 133 HIS A O     1 
ATOM   972  C  CB    . HIS A 1 124 ? -23.655 -20.644 -10.630 1.00 40.62  ? 133 HIS A CB    1 
ATOM   973  C  CG    . HIS A 1 124 ? -24.925 -19.999 -10.222 1.00 41.55  ? 133 HIS A CG    1 
ATOM   974  N  ND1   . HIS A 1 124 ? -25.991 -19.865 -11.089 1.00 41.72  ? 133 HIS A ND1   1 
ATOM   975  C  CD2   . HIS A 1 124 ? -25.288 -19.417 -9.056  1.00 47.82  ? 133 HIS A CD2   1 
ATOM   976  C  CE1   . HIS A 1 124 ? -26.975 -19.262 -10.462 1.00 44.30  ? 133 HIS A CE1   1 
ATOM   977  N  NE2   . HIS A 1 124 ? -26.577 -18.993 -9.192  1.00 42.28  ? 133 HIS A NE2   1 
ATOM   978  N  N     . GLY A 1 125 ? -20.145 -20.723 -9.908  1.00 35.20  ? 134 GLY A N     1 
ATOM   979  C  CA    . GLY A 1 125 ? -18.880 -21.399 -10.247 1.00 36.45  ? 134 GLY A CA    1 
ATOM   980  C  C     . GLY A 1 125 ? -18.468 -21.170 -11.697 1.00 39.72  ? 134 GLY A C     1 
ATOM   981  O  O     . GLY A 1 125 ? -19.041 -20.270 -12.334 1.00 38.95  ? 134 GLY A O     1 
ATOM   982  N  N     . ASN A 1 126 ? -17.508 -21.970 -12.176 1.00 42.80  ? 135 ASN A N     1 
ATOM   983  C  CA    . ASN A 1 126 ? -16.745 -21.769 -13.436 1.00 40.78  ? 135 ASN A CA    1 
ATOM   984  C  C     . ASN A 1 126 ? -16.259 -23.109 -13.957 1.00 40.28  ? 135 ASN A C     1 
ATOM   985  O  O     . ASN A 1 126 ? -15.571 -23.778 -13.191 1.00 36.76  ? 135 ASN A O     1 
ATOM   986  C  CB    . ASN A 1 126 ? -15.461 -20.985 -13.188 1.00 44.06  ? 135 ASN A CB    1 
ATOM   987  C  CG    . ASN A 1 126 ? -14.827 -20.461 -14.452 1.00 34.90  ? 135 ASN A CG    1 
ATOM   988  O  OD1   . ASN A 1 126 ? -14.719 -21.122 -15.480 1.00 37.97  ? 135 ASN A OD1   1 
ATOM   989  N  ND2   . ASN A 1 126 ? -14.404 -19.239 -14.357 1.00 37.38  ? 135 ASN A ND2   1 
ATOM   990  N  N     . MET A 1 127 ? -16.627 -23.470 -15.184 1.00 40.85  ? 136 MET A N     1 
ATOM   991  C  CA    . MET A 1 127 ? -16.278 -24.779 -15.784 1.00 43.40  ? 136 MET A CA    1 
ATOM   992  C  C     . MET A 1 127 ? -14.766 -24.978 -15.788 1.00 40.69  ? 136 MET A C     1 
ATOM   993  O  O     . MET A 1 127 ? -14.355 -26.135 -15.763 1.00 43.70  ? 136 MET A O     1 
ATOM   994  C  CB    . MET A 1 127 ? -16.759 -24.891 -17.227 1.00 50.82  ? 136 MET A CB    1 
ATOM   995  C  CG    . MET A 1 127 ? -17.781 -25.959 -17.417 1.00 59.14  ? 136 MET A CG    1 
ATOM   996  S  SD    . MET A 1 127 ? -19.347 -25.214 -17.163 1.00 59.96  ? 136 MET A SD    1 
ATOM   997  C  CE    . MET A 1 127 ? -19.623 -24.603 -18.830 1.00 60.87  ? 136 MET A CE    1 
ATOM   998  N  N     . PHE A 1 128 ? -13.994 -23.902 -15.947 1.00 43.97  ? 137 PHE A N     1 
ATOM   999  C  CA    . PHE A 1 128 ? -12.524 -23.947 -16.165 1.00 41.52  ? 137 PHE A CA    1 
ATOM   1000 C  C     . PHE A 1 128 ? -11.768 -24.014 -14.828 1.00 40.71  ? 137 PHE A C     1 
ATOM   1001 O  O     . PHE A 1 128 ? -10.571 -24.217 -14.857 1.00 44.62  ? 137 PHE A O     1 
ATOM   1002 C  CB    . PHE A 1 128 ? -12.073 -22.743 -16.989 1.00 37.75  ? 137 PHE A CB    1 
ATOM   1003 C  CG    . PHE A 1 128 ? -12.618 -22.716 -18.394 1.00 39.11  ? 137 PHE A CG    1 
ATOM   1004 C  CD1   . PHE A 1 128 ? -13.843 -22.125 -18.672 1.00 40.87  ? 137 PHE A CD1   1 
ATOM   1005 C  CD2   . PHE A 1 128 ? -11.932 -23.318 -19.436 1.00 41.67  ? 137 PHE A CD2   1 
ATOM   1006 C  CE1   . PHE A 1 128 ? -14.337 -22.100 -19.972 1.00 40.25  ? 137 PHE A CE1   1 
ATOM   1007 C  CE2   . PHE A 1 128 ? -12.428 -23.285 -20.735 1.00 39.68  ? 137 PHE A CE2   1 
ATOM   1008 C  CZ    . PHE A 1 128 ? -13.634 -22.694 -21.001 1.00 36.83  ? 137 PHE A CZ    1 
ATOM   1009 N  N     . VAL A 1 129 ? -12.424 -23.910 -13.682 1.00 36.34  ? 138 VAL A N     1 
ATOM   1010 C  CA    . VAL A 1 129 ? -11.698 -23.751 -12.399 1.00 37.05  ? 138 VAL A CA    1 
ATOM   1011 C  C     . VAL A 1 129 ? -11.863 -25.003 -11.535 1.00 41.55  ? 138 VAL A C     1 
ATOM   1012 O  O     . VAL A 1 129 ? -12.985 -25.483 -11.369 1.00 48.17  ? 138 VAL A O     1 
ATOM   1013 C  CB    . VAL A 1 129 ? -12.171 -22.491 -11.671 1.00 40.42  ? 138 VAL A CB    1 
ATOM   1014 C  CG1   . VAL A 1 129 ? -11.668 -22.455 -10.226 1.00 41.82  ? 138 VAL A CG1   1 
ATOM   1015 C  CG2   . VAL A 1 129 ? -11.744 -21.262 -12.444 1.00 34.43  ? 138 VAL A CG2   1 
ATOM   1016 N  N     . GLU A 1 130 ? -10.755 -25.500 -10.993 1.00 46.77  ? 139 GLU A N     1 
ATOM   1017 C  CA    . GLU A 1 130 ? -10.759 -26.568 -9.967  1.00 49.37  ? 139 GLU A CA    1 
ATOM   1018 C  C     . GLU A 1 130 ? -10.194 -25.953 -8.689  1.00 51.90  ? 139 GLU A C     1 
ATOM   1019 O  O     . GLU A 1 130 ? -9.314  -25.053 -8.782  1.00 48.25  ? 139 GLU A O     1 
ATOM   1020 C  CB    . GLU A 1 130 ? -10.032 -27.851 -10.395 1.00 49.90  ? 139 GLU A CB    1 
ATOM   1021 C  CG    . GLU A 1 130 ? -8.848  -27.710 -11.326 1.00 52.83  ? 139 GLU A CG    1 
ATOM   1022 C  CD    . GLU A 1 130 ? -8.421  -29.024 -11.968 1.00 52.44  ? 139 GLU A CD    1 
ATOM   1023 O  OE1   . GLU A 1 130 ? -9.151  -29.998 -11.831 1.00 52.02  ? 139 GLU A OE1   1 
ATOM   1024 O  OE2   . GLU A 1 130 ? -7.337  -29.081 -12.582 1.00 52.62  ? 139 GLU A OE2   1 
ATOM   1025 N  N     . GLU A 1 131 ? -10.725 -26.388 -7.553  1.00 48.10  ? 140 GLU A N     1 
ATOM   1026 C  CA    . GLU A 1 131 ? -10.304 -25.914 -6.217  1.00 60.30  ? 140 GLU A CA    1 
ATOM   1027 C  C     . GLU A 1 131 ? -9.447  -27.016 -5.601  1.00 62.38  ? 140 GLU A C     1 
ATOM   1028 O  O     . GLU A 1 131 ? -9.402  -28.071 -6.194  1.00 72.26  ? 140 GLU A O     1 
ATOM   1029 C  CB    . GLU A 1 131 ? -11.522 -25.580 -5.356  1.00 60.85  ? 140 GLU A CB    1 
ATOM   1030 C  CG    . GLU A 1 131 ? -11.168 -24.632 -4.234  1.00 64.79  ? 140 GLU A CG    1 
ATOM   1031 C  CD    . GLU A 1 131 ? -12.280 -23.723 -3.757  1.00 64.84  ? 140 GLU A CD    1 
ATOM   1032 O  OE1   . GLU A 1 131 ? -13.126 -23.344 -4.576  1.00 72.78  ? 140 GLU A OE1   1 
ATOM   1033 O  OE2   . GLU A 1 131 ? -12.271 -23.385 -2.566  1.00 76.32  ? 140 GLU A OE2   1 
ATOM   1034 N  N     . CYS A 1 132 ? -8.777  -26.779 -4.482  1.00 61.21  ? 141 CYS A N     1 
ATOM   1035 C  CA    . CYS A 1 132 ? -8.151  -27.861 -3.689  1.00 59.94  ? 141 CYS A CA    1 
ATOM   1036 C  C     . CYS A 1 132 ? -9.026  -28.085 -2.454  1.00 60.53  ? 141 CYS A C     1 
ATOM   1037 O  O     . CYS A 1 132 ? -9.342  -27.109 -1.744  1.00 56.62  ? 141 CYS A O     1 
ATOM   1038 C  CB    . CYS A 1 132 ? -6.720  -27.503 -3.313  1.00 66.86  ? 141 CYS A CB    1 
ATOM   1039 S  SG    . CYS A 1 132 ? -5.887  -28.731 -2.266  1.00 76.56  ? 141 CYS A SG    1 
ATOM   1040 N  N     . ALA A 1 133 ? -9.452  -29.317 -2.221  1.00 65.08  ? 142 ALA A N     1 
ATOM   1041 C  CA    . ALA A 1 133 ? -10.255 -29.684 -1.035  1.00 65.69  ? 142 ALA A CA    1 
ATOM   1042 C  C     . ALA A 1 133 ? -9.528  -29.207 0.220   1.00 68.16  ? 142 ALA A C     1 
ATOM   1043 O  O     . ALA A 1 133 ? -10.198 -28.661 1.099   1.00 64.38  ? 142 ALA A O     1 
ATOM   1044 C  CB    . ALA A 1 133 ? -10.494 -31.163 -0.990  1.00 68.30  ? 142 ALA A CB    1 
ATOM   1045 N  N     . LYS A 1 134 ? -8.203  -29.364 0.257   1.00 73.85  ? 143 LYS A N     1 
ATOM   1046 C  CA    . LYS A 1 134 ? -7.369  -29.048 1.447   1.00 81.26  ? 143 LYS A CA    1 
ATOM   1047 C  C     . LYS A 1 134 ? -6.953  -27.573 1.417   1.00 83.79  ? 143 LYS A C     1 
ATOM   1048 O  O     . LYS A 1 134 ? -7.279  -26.832 2.357   1.00 90.26  ? 143 LYS A O     1 
ATOM   1049 C  CB    . LYS A 1 134 ? -6.123  -29.936 1.471   1.00 90.69  ? 143 LYS A CB    1 
ATOM   1050 C  CG    . LYS A 1 134 ? -6.367  -31.437 1.579   1.00 95.46  ? 143 LYS A CG    1 
ATOM   1051 C  CD    . LYS A 1 134 ? -5.081  -32.212 1.862   1.00 100.82 ? 143 LYS A CD    1 
ATOM   1052 C  CE    . LYS A 1 134 ? -5.256  -33.715 1.957   1.00 100.95 ? 143 LYS A CE    1 
ATOM   1053 N  NZ    . LYS A 1 134 ? -3.953  -34.417 1.863   1.00 103.51 ? 143 LYS A NZ    1 
ATOM   1054 N  N     . CYS A 1 135 ? -6.234  -27.178 0.373   1.00 77.55  ? 144 CYS A N     1 
ATOM   1055 C  CA    . CYS A 1 135 ? -5.569  -25.858 0.259   1.00 73.05  ? 144 CYS A CA    1 
ATOM   1056 C  C     . CYS A 1 135 ? -6.626  -24.757 0.141   1.00 67.30  ? 144 CYS A C     1 
ATOM   1057 O  O     . CYS A 1 135 ? -6.412  -23.707 0.704   1.00 60.89  ? 144 CYS A O     1 
ATOM   1058 C  CB    . CYS A 1 135 ? -4.651  -25.864 -0.957  1.00 71.93  ? 144 CYS A CB    1 
ATOM   1059 S  SG    . CYS A 1 135 ? -3.421  -24.545 -0.972  1.00 93.95  ? 144 CYS A SG    1 
ATOM   1060 N  N     . LYS A 1 136 ? -7.715  -25.028 -0.592  1.00 76.73  ? 145 LYS A N     1 
ATOM   1061 C  CA    . LYS A 1 136 ? -8.747  -24.057 -1.075  1.00 70.12  ? 145 LYS A CA    1 
ATOM   1062 C  C     . LYS A 1 136 ? -8.154  -23.138 -2.151  1.00 60.42  ? 145 LYS A C     1 
ATOM   1063 O  O     . LYS A 1 136 ? -8.693  -22.026 -2.403  1.00 64.17  ? 145 LYS A O     1 
ATOM   1064 C  CB    . LYS A 1 136 ? -9.411  -23.313 0.091   1.00 76.69  ? 145 LYS A CB    1 
ATOM   1065 C  CG    . LYS A 1 136 ? -10.904 -23.634 0.252   1.00 87.19  ? 145 LYS A CG    1 
ATOM   1066 C  CD    . LYS A 1 136 ? -11.345 -24.107 1.638   1.00 91.19  ? 145 LYS A CD    1 
ATOM   1067 C  CE    . LYS A 1 136 ? -11.331 -25.616 1.813   1.00 95.77  ? 145 LYS A CE    1 
ATOM   1068 N  NZ    . LYS A 1 136 ? -12.380 -26.289 1.010   1.00 96.00  ? 145 LYS A NZ    1 
ATOM   1069 N  N     . THR A 1 137 ? -7.112  -23.613 -2.813  1.00 52.10  ? 146 THR A N     1 
ATOM   1070 C  CA    . THR A 1 137 ? -6.399  -22.882 -3.882  1.00 57.67  ? 146 THR A CA    1 
ATOM   1071 C  C     . THR A 1 137 ? -7.089  -23.175 -5.202  1.00 51.18  ? 146 THR A C     1 
ATOM   1072 O  O     . THR A 1 137 ? -7.543  -24.290 -5.358  1.00 47.47  ? 146 THR A O     1 
ATOM   1073 C  CB    . THR A 1 137 ? -4.935  -23.299 -3.948  1.00 65.36  ? 146 THR A CB    1 
ATOM   1074 O  OG1   . THR A 1 137 ? -4.573  -23.523 -2.586  1.00 78.15  ? 146 THR A OG1   1 
ATOM   1075 C  CG2   . THR A 1 137 ? -4.065  -22.258 -4.612  1.00 64.77  ? 146 THR A CG2   1 
ATOM   1076 N  N     . GLN A 1 138 ? -7.159  -22.200 -6.095  1.00 56.36  ? 147 GLN A N     1 
ATOM   1077 C  CA    . GLN A 1 138 ? -7.957  -22.292 -7.339  1.00 55.34  ? 147 GLN A CA    1 
ATOM   1078 C  C     . GLN A 1 138 ? -7.028  -22.323 -8.553  1.00 53.71  ? 147 GLN A C     1 
ATOM   1079 O  O     . GLN A 1 138 ? -6.228  -21.436 -8.695  1.00 59.13  ? 147 GLN A O     1 
ATOM   1080 C  CB    . GLN A 1 138 ? -8.917  -21.113 -7.395  1.00 51.45  ? 147 GLN A CB    1 
ATOM   1081 C  CG    . GLN A 1 138 ? -10.073 -21.289 -6.444  1.00 54.35  ? 147 GLN A CG    1 
ATOM   1082 C  CD    . GLN A 1 138 ? -11.003 -20.113 -6.493  1.00 57.41  ? 147 GLN A CD    1 
ATOM   1083 O  OE1   . GLN A 1 138 ? -10.553 -18.971 -6.539  1.00 68.27  ? 147 GLN A OE1   1 
ATOM   1084 N  NE2   . GLN A 1 138 ? -12.302 -20.386 -6.463  1.00 58.35  ? 147 GLN A NE2   1 
ATOM   1085 N  N     . TYR A 1 139 ? -7.179  -23.303 -9.423  1.00 52.69  ? 148 TYR A N     1 
ATOM   1086 C  CA    . TYR A 1 139 ? -6.416  -23.384 -10.684 1.00 52.89  ? 148 TYR A CA    1 
ATOM   1087 C  C     . TYR A 1 139 ? -7.353  -23.043 -11.841 1.00 49.02  ? 148 TYR A C     1 
ATOM   1088 O  O     . TYR A 1 139 ? -8.377  -23.701 -11.983 1.00 47.25  ? 148 TYR A O     1 
ATOM   1089 C  CB    . TYR A 1 139 ? -5.849  -24.792 -10.854 1.00 54.34  ? 148 TYR A CB    1 
ATOM   1090 C  CG    . TYR A 1 139 ? -4.922  -25.227 -9.761  1.00 46.57  ? 148 TYR A CG    1 
ATOM   1091 C  CD1   . TYR A 1 139 ? -5.418  -25.663 -8.547  1.00 63.48  ? 148 TYR A CD1   1 
ATOM   1092 C  CD2   . TYR A 1 139 ? -3.558  -25.252 -9.948  1.00 60.41  ? 148 TYR A CD2   1 
ATOM   1093 C  CE1   . TYR A 1 139 ? -4.580  -26.085 -7.527  1.00 57.88  ? 148 TYR A CE1   1 
ATOM   1094 C  CE2   . TYR A 1 139 ? -2.698  -25.658 -8.937  1.00 67.97  ? 148 TYR A CE2   1 
ATOM   1095 C  CZ    . TYR A 1 139 ? -3.213  -26.074 -7.720  1.00 61.70  ? 148 TYR A CZ    1 
ATOM   1096 O  OH    . TYR A 1 139 ? -2.377  -26.483 -6.729  1.00 64.01  ? 148 TYR A OH    1 
ATOM   1097 N  N     . VAL A 1 140 ? -6.998  -22.056 -12.652 1.00 46.02  ? 149 VAL A N     1 
ATOM   1098 C  CA    . VAL A 1 140 ? -7.767  -21.672 -13.866 1.00 39.67  ? 149 VAL A CA    1 
ATOM   1099 C  C     . VAL A 1 140 ? -7.143  -22.376 -15.064 1.00 38.70  ? 149 VAL A C     1 
ATOM   1100 O  O     . VAL A 1 140 ? -6.016  -22.021 -15.387 1.00 41.73  ? 149 VAL A O     1 
ATOM   1101 C  CB    . VAL A 1 140 ? -7.747  -20.154 -14.024 1.00 42.91  ? 149 VAL A CB    1 
ATOM   1102 C  CG1   . VAL A 1 140 ? -8.611  -19.694 -15.195 1.00 45.36  ? 149 VAL A CG1   1 
ATOM   1103 C  CG2   . VAL A 1 140 ? -8.193  -19.515 -12.721 1.00 41.19  ? 149 VAL A CG2   1 
ATOM   1104 N  N     . ARG A 1 141 ? -7.841  -23.334 -15.670 1.00 37.59  ? 150 ARG A N     1 
ATOM   1105 C  CA    . ARG A 1 141 ? -7.280  -24.202 -16.735 1.00 44.02  ? 150 ARG A CA    1 
ATOM   1106 C  C     . ARG A 1 141 ? -7.665  -23.672 -18.117 1.00 39.09  ? 150 ARG A C     1 
ATOM   1107 O  O     . ARG A 1 141 ? -8.569  -22.879 -18.214 1.00 45.11  ? 150 ARG A O     1 
ATOM   1108 C  CB    . ARG A 1 141 ? -7.737  -25.654 -16.567 1.00 45.05  ? 150 ARG A CB    1 
ATOM   1109 C  CG    . ARG A 1 141 ? -7.460  -26.244 -15.186 1.00 46.23  ? 150 ARG A CG    1 
ATOM   1110 C  CD    . ARG A 1 141 ? -5.978  -26.351 -14.933 1.00 48.68  ? 150 ARG A CD    1 
ATOM   1111 N  NE    . ARG A 1 141 ? -5.652  -26.994 -13.676 1.00 53.36  ? 150 ARG A NE    1 
ATOM   1112 C  CZ    . ARG A 1 141 ? -4.422  -27.319 -13.281 1.00 56.52  ? 150 ARG A CZ    1 
ATOM   1113 N  NH1   . ARG A 1 141 ? -3.380  -27.085 -14.054 1.00 56.13  ? 150 ARG A NH1   1 
ATOM   1114 N  NH2   . ARG A 1 141 ? -4.252  -27.935 -12.127 1.00 60.61  ? 150 ARG A NH2   1 
ATOM   1115 N  N     . ASP A 1 142 ? -6.985  -24.153 -19.144 1.00 41.26  ? 151 ASP A N     1 
ATOM   1116 C  CA    . ASP A 1 142 ? -7.175  -23.744 -20.557 1.00 44.50  ? 151 ASP A CA    1 
ATOM   1117 C  C     . ASP A 1 142 ? -8.294  -24.573 -21.191 1.00 44.97  ? 151 ASP A C     1 
ATOM   1118 O  O     . ASP A 1 142 ? -8.528  -24.397 -22.415 1.00 51.06  ? 151 ASP A O     1 
ATOM   1119 C  CB    . ASP A 1 142 ? -5.859  -23.911 -21.336 1.00 46.26  ? 151 ASP A CB    1 
ATOM   1120 C  CG    . ASP A 1 142 ? -5.312  -25.337 -21.422 1.00 49.92  ? 151 ASP A CG    1 
ATOM   1121 O  OD1   . ASP A 1 142 ? -6.008  -26.285 -20.966 1.00 53.61  ? 151 ASP A OD1   1 
ATOM   1122 O  OD2   . ASP A 1 142 ? -4.187  -25.513 -21.962 1.00 53.50  ? 151 ASP A OD2   1 
ATOM   1123 N  N     . THR A 1 143 ? -8.857  -25.540 -20.458 1.00 42.34  ? 152 THR A N     1 
ATOM   1124 C  CA    . THR A 1 143 ? -9.974  -26.402 -20.925 1.00 41.37  ? 152 THR A CA    1 
ATOM   1125 C  C     . THR A 1 143 ? -10.890 -26.669 -19.737 1.00 43.03  ? 152 THR A C     1 
ATOM   1126 O  O     . THR A 1 143 ? -10.485 -26.370 -18.587 1.00 44.74  ? 152 THR A O     1 
ATOM   1127 C  CB    . THR A 1 143 ? -9.541  -27.719 -21.606 1.00 44.47  ? 152 THR A CB    1 
ATOM   1128 O  OG1   . THR A 1 143 ? -8.654  -28.487 -20.798 1.00 45.30  ? 152 THR A OG1   1 
ATOM   1129 C  CG2   . THR A 1 143 ? -8.882  -27.545 -22.955 1.00 45.55  ? 152 THR A CG2   1 
ATOM   1130 N  N     . VAL A 1 144 ? -12.088 -27.184 -20.023 1.00 44.02  ? 153 VAL A N     1 
ATOM   1131 C  CA    . VAL A 1 144 ? -13.119 -27.456 -18.995 1.00 47.96  ? 153 VAL A CA    1 
ATOM   1132 C  C     . VAL A 1 144 ? -12.681 -28.676 -18.211 1.00 50.40  ? 153 VAL A C     1 
ATOM   1133 O  O     . VAL A 1 144 ? -12.289 -29.652 -18.839 1.00 52.87  ? 153 VAL A O     1 
ATOM   1134 C  CB    . VAL A 1 144 ? -14.509 -27.670 -19.608 1.00 55.66  ? 153 VAL A CB    1 
ATOM   1135 C  CG1   . VAL A 1 144 ? -15.062 -26.366 -20.143 1.00 55.39  ? 153 VAL A CG1   1 
ATOM   1136 C  CG2   . VAL A 1 144 ? -14.522 -28.782 -20.657 1.00 54.33  ? 153 VAL A CG2   1 
ATOM   1137 N  N     . VAL A 1 145 ? -12.873 -28.645 -16.903 1.00 55.33  ? 154 VAL A N     1 
ATOM   1138 C  CA    . VAL A 1 145 ? -12.256 -29.615 -15.947 1.00 58.49  ? 154 VAL A CA    1 
ATOM   1139 C  C     . VAL A 1 145 ? -12.842 -31.030 -16.109 1.00 58.60  ? 154 VAL A C     1 
ATOM   1140 O  O     . VAL A 1 145 ? -12.055 -31.996 -16.104 1.00 67.39  ? 154 VAL A O     1 
ATOM   1141 C  CB    . VAL A 1 145 ? -12.349 -29.084 -14.508 1.00 55.84  ? 154 VAL A CB    1 
ATOM   1142 C  CG1   . VAL A 1 145 ? -11.906 -27.641 -14.443 1.00 51.78  ? 154 VAL A CG1   1 
ATOM   1143 C  CG2   . VAL A 1 145 ? -13.717 -29.253 -13.885 1.00 60.04  ? 154 VAL A CG2   1 
ATOM   1144 N  N     . GLY A 1 146 ? -14.139 -31.187 -16.322 1.00 59.01  ? 155 GLY A N     1 
ATOM   1145 C  CA    . GLY A 1 146 ? -14.680 -32.533 -16.581 1.00 52.35  ? 155 GLY A CA    1 
ATOM   1146 C  C     . GLY A 1 146 ? -15.939 -32.788 -15.792 1.00 54.32  ? 155 GLY A C     1 
ATOM   1147 O  O     . GLY A 1 146 ? -16.837 -33.431 -16.336 1.00 55.72  ? 155 GLY A O     1 
ATOM   1148 N  N     . THR A 1 147 ? -16.065 -32.258 -14.576 1.00 55.80  ? 156 THR A N     1 
ATOM   1149 C  CA    . THR A 1 147 ? -17.145 -32.693 -13.655 1.00 58.58  ? 156 THR A CA    1 
ATOM   1150 C  C     . THR A 1 147 ? -18.014 -31.502 -13.241 1.00 58.73  ? 156 THR A C     1 
ATOM   1151 O  O     . THR A 1 147 ? -17.615 -30.392 -13.526 1.00 59.62  ? 156 THR A O     1 
ATOM   1152 C  CB    . THR A 1 147 ? -16.532 -33.501 -12.504 1.00 58.43  ? 156 THR A CB    1 
ATOM   1153 O  OG1   . THR A 1 147 ? -15.668 -32.657 -11.740 1.00 51.42  ? 156 THR A OG1   1 
ATOM   1154 C  CG2   . THR A 1 147 ? -15.763 -34.699 -13.015 1.00 52.68  ? 156 THR A CG2   1 
ATOM   1155 N  N     . MET A 1 148 ? -19.183 -31.767 -12.646 1.00 59.85  ? 157 MET A N     1 
ATOM   1156 C  CA    . MET A 1 148 ? -20.086 -30.749 -12.044 1.00 68.04  ? 157 MET A CA    1 
ATOM   1157 C  C     . MET A 1 148 ? -20.538 -31.284 -10.692 1.00 62.48  ? 157 MET A C     1 
ATOM   1158 O  O     . MET A 1 148 ? -20.579 -32.495 -10.553 1.00 65.53  ? 157 MET A O     1 
ATOM   1159 C  CB    . MET A 1 148 ? -21.318 -30.461 -12.926 1.00 80.12  ? 157 MET A CB    1 
ATOM   1160 C  CG    . MET A 1 148 ? -22.669 -31.098 -12.473 1.00 84.59  ? 157 MET A CG    1 
ATOM   1161 S  SD    . MET A 1 148 ? -24.084 -29.930 -12.230 1.00 82.21  ? 157 MET A SD    1 
ATOM   1162 C  CE    . MET A 1 148 ? -25.463 -31.029 -12.549 1.00 89.61  ? 157 MET A CE    1 
ATOM   1163 N  N     . GLY A 1 149 ? -20.940 -30.411 -9.772  1.00 62.07  ? 158 GLY A N     1 
ATOM   1164 C  CA    . GLY A 1 149 ? -21.484 -30.808 -8.455  1.00 62.16  ? 158 GLY A CA    1 
ATOM   1165 C  C     . GLY A 1 149 ? -20.409 -31.047 -7.403  1.00 59.82  ? 158 GLY A C     1 
ATOM   1166 O  O     . GLY A 1 149 ? -20.699 -31.807 -6.455  1.00 55.55  ? 158 GLY A O     1 
ATOM   1167 N  N     . LEU A 1 150 ? -19.236 -30.408 -7.557  1.00 56.15  ? 159 LEU A N     1 
ATOM   1168 C  CA    . LEU A 1 150 ? -18.082 -30.439 -6.616  1.00 60.42  ? 159 LEU A CA    1 
ATOM   1169 C  C     . LEU A 1 150 ? -17.538 -31.863 -6.440  1.00 65.16  ? 159 LEU A C     1 
ATOM   1170 O  O     . LEU A 1 150 ? -17.329 -32.269 -5.288  1.00 60.37  ? 159 LEU A O     1 
ATOM   1171 C  CB    . LEU A 1 150 ? -18.516 -29.863 -5.267  1.00 53.70  ? 159 LEU A CB    1 
ATOM   1172 C  CG    . LEU A 1 150 ? -19.304 -28.563 -5.345  1.00 63.80  ? 159 LEU A CG    1 
ATOM   1173 C  CD1   . LEU A 1 150 ? -19.475 -27.970 -3.956  1.00 61.68  ? 159 LEU A CD1   1 
ATOM   1174 C  CD2   . LEU A 1 150 ? -18.630 -27.551 -6.282  1.00 65.59  ? 159 LEU A CD2   1 
ATOM   1175 N  N     . LYS A 1 151 ? -17.264 -32.571 -7.535  1.00 67.29  ? 160 LYS A N     1 
ATOM   1176 C  CA    . LYS A 1 151 ? -16.684 -33.940 -7.478  1.00 74.71  ? 160 LYS A CA    1 
ATOM   1177 C  C     . LYS A 1 151 ? -15.218 -33.855 -7.921  1.00 70.20  ? 160 LYS A C     1 
ATOM   1178 O  O     . LYS A 1 151 ? -14.858 -32.860 -8.569  1.00 78.46  ? 160 LYS A O     1 
ATOM   1179 C  CB    . LYS A 1 151 ? -17.584 -34.912 -8.254  1.00 82.45  ? 160 LYS A CB    1 
ATOM   1180 C  CG    . LYS A 1 151 ? -18.944 -35.149 -7.593  1.00 88.15  ? 160 LYS A CG    1 
ATOM   1181 C  CD    . LYS A 1 151 ? -19.678 -36.425 -7.990  1.00 88.75  ? 160 LYS A CD    1 
ATOM   1182 C  CE    . LYS A 1 151 ? -20.674 -36.876 -6.936  1.00 88.05  ? 160 LYS A CE    1 
ATOM   1183 N  NZ    . LYS A 1 151 ? -21.356 -38.146 -7.299  1.00 87.07  ? 160 LYS A NZ    1 
ATOM   1184 N  N     . ALA A 1 152 ? -14.394 -34.817 -7.501  1.00 70.27  ? 161 ALA A N     1 
ATOM   1185 C  CA    . ALA A 1 152 ? -12.940 -34.895 -7.785  1.00 70.69  ? 161 ALA A CA    1 
ATOM   1186 C  C     . ALA A 1 152 ? -12.716 -35.028 -9.293  1.00 73.10  ? 161 ALA A C     1 
ATOM   1187 O  O     . ALA A 1 152 ? -13.395 -35.869 -9.917  1.00 75.86  ? 161 ALA A O     1 
ATOM   1188 C  CB    . ALA A 1 152 ? -12.322 -36.068 -7.067  1.00 66.78  ? 161 ALA A CB    1 
ATOM   1189 N  N     . THR A 1 153 ? -11.784 -34.252 -9.846  1.00 68.83  ? 162 THR A N     1 
ATOM   1190 C  CA    . THR A 1 153 ? -11.482 -34.223 -11.302 1.00 69.79  ? 162 THR A CA    1 
ATOM   1191 C  C     . THR A 1 153 ? -10.473 -35.329 -11.653 1.00 63.35  ? 162 THR A C     1 
ATOM   1192 O  O     . THR A 1 153 ? -10.533 -35.813 -12.798 1.00 57.06  ? 162 THR A O     1 
ATOM   1193 C  CB    . THR A 1 153 ? -11.018 -32.823 -11.709 1.00 71.79  ? 162 THR A CB    1 
ATOM   1194 O  OG1   . THR A 1 153 ? -9.831  -32.509 -10.984 1.00 68.46  ? 162 THR A OG1   1 
ATOM   1195 C  CG2   . THR A 1 153 ? -12.062 -31.769 -11.421 1.00 72.59  ? 162 THR A CG2   1 
ATOM   1196 N  N     . GLY A 1 154 ? -9.600  -35.716 -10.710 1.00 61.07  ? 163 GLY A N     1 
ATOM   1197 C  CA    . GLY A 1 154 ? -8.511  -36.690 -10.939 1.00 57.99  ? 163 GLY A CA    1 
ATOM   1198 C  C     . GLY A 1 154 ? -7.123  -36.063 -10.844 1.00 68.18  ? 163 GLY A C     1 
ATOM   1199 O  O     . GLY A 1 154 ? -6.090  -36.833 -10.911 1.00 53.59  ? 163 GLY A O     1 
ATOM   1200 N  N     . ARG A 1 155 ? -7.064  -34.733 -10.675 1.00 69.41  ? 164 ARG A N     1 
ATOM   1201 C  CA    . ARG A 1 155 ? -5.790  -33.980 -10.508 1.00 62.61  ? 164 ARG A CA    1 
ATOM   1202 C  C     . ARG A 1 155 ? -5.595  -33.632 -9.030  1.00 58.67  ? 164 ARG A C     1 
ATOM   1203 O  O     . ARG A 1 155 ? -6.585  -33.648 -8.280  1.00 63.18  ? 164 ARG A O     1 
ATOM   1204 C  CB    . ARG A 1 155 ? -5.767  -32.755 -11.422 1.00 61.08  ? 164 ARG A CB    1 
ATOM   1205 C  CG    . ARG A 1 155 ? -5.510  -33.120 -12.879 1.00 66.47  ? 164 ARG A CG    1 
ATOM   1206 C  CD    . ARG A 1 155 ? -5.747  -31.952 -13.805 1.00 66.62  ? 164 ARG A CD    1 
ATOM   1207 N  NE    . ARG A 1 155 ? -7.152  -31.597 -13.861 1.00 65.03  ? 164 ARG A NE    1 
ATOM   1208 C  CZ    . ARG A 1 155 ? -8.057  -32.175 -14.646 1.00 67.77  ? 164 ARG A CZ    1 
ATOM   1209 N  NH1   . ARG A 1 155 ? -7.706  -33.152 -15.461 1.00 59.12  ? 164 ARG A NH1   1 
ATOM   1210 N  NH2   . ARG A 1 155 ? -9.313  -31.750 -14.625 1.00 67.31  ? 164 ARG A NH2   1 
ATOM   1211 N  N     . LEU A 1 156 ? -4.347  -33.367 -8.645  1.00 55.98  ? 165 LEU A N     1 
ATOM   1212 C  CA    . LEU A 1 156 ? -3.918  -33.100 -7.254  1.00 63.07  ? 165 LEU A CA    1 
ATOM   1213 C  C     . LEU A 1 156 ? -3.246  -31.728 -7.167  1.00 61.65  ? 165 LEU A C     1 
ATOM   1214 O  O     . LEU A 1 156 ? -2.738  -31.240 -8.192  1.00 62.78  ? 165 LEU A O     1 
ATOM   1215 C  CB    . LEU A 1 156 ? -2.957  -34.208 -6.806  1.00 62.87  ? 165 LEU A CB    1 
ATOM   1216 C  CG    . LEU A 1 156 ? -3.564  -35.600 -6.717  1.00 62.14  ? 165 LEU A CG    1 
ATOM   1217 C  CD1   . LEU A 1 156 ? -2.524  -36.601 -6.245  1.00 64.29  ? 165 LEU A CD1   1 
ATOM   1218 C  CD2   . LEU A 1 156 ? -4.774  -35.597 -5.788  1.00 64.09  ? 165 LEU A CD2   1 
ATOM   1219 N  N     . CYS A 1 157 ? -3.223  -31.162 -5.961  1.00 64.07  ? 166 CYS A N     1 
ATOM   1220 C  CA    . CYS A 1 157 ? -2.666  -29.821 -5.662  1.00 67.79  ? 166 CYS A CA    1 
ATOM   1221 C  C     . CYS A 1 157 ? -1.136  -29.845 -5.758  1.00 65.25  ? 166 CYS A C     1 
ATOM   1222 O  O     . CYS A 1 157 ? -0.533  -30.850 -5.411  1.00 64.20  ? 166 CYS A O     1 
ATOM   1223 C  CB    . CYS A 1 157 ? -3.078  -29.387 -4.269  1.00 76.89  ? 166 CYS A CB    1 
ATOM   1224 S  SG    . CYS A 1 157 ? -2.898  -27.605 -4.056  1.00 94.30  ? 166 CYS A SG    1 
ATOM   1225 N  N     . THR A 1 158 ? -0.538  -28.763 -6.227  1.00 65.94  ? 167 THR A N     1 
ATOM   1226 C  CA    . THR A 1 158 ? 0.893   -28.696 -6.602  1.00 61.30  ? 167 THR A CA    1 
ATOM   1227 C  C     . THR A 1 158 ? 1.565   -27.573 -5.815  1.00 66.63  ? 167 THR A C     1 
ATOM   1228 O  O     . THR A 1 158 ? 2.663   -27.172 -6.210  1.00 57.05  ? 167 THR A O     1 
ATOM   1229 C  CB    . THR A 1 158 ? 1.024   -28.520 -8.122  1.00 60.46  ? 167 THR A CB    1 
ATOM   1230 O  OG1   . THR A 1 158 ? 0.044   -27.580 -8.564  1.00 55.52  ? 167 THR A OG1   1 
ATOM   1231 C  CG2   . THR A 1 158 ? 0.820   -29.816 -8.876  1.00 61.06  ? 167 THR A CG2   1 
ATOM   1232 N  N     . VAL A 1 159 ? 0.938   -27.096 -4.734  1.00 78.85  ? 168 VAL A N     1 
ATOM   1233 C  CA    . VAL A 1 159 ? 1.563   -26.119 -3.791  1.00 83.88  ? 168 VAL A CA    1 
ATOM   1234 C  C     . VAL A 1 159 ? 2.654   -26.863 -3.004  1.00 81.87  ? 168 VAL A C     1 
ATOM   1235 O  O     . VAL A 1 159 ? 2.485   -28.064 -2.755  1.00 92.89  ? 168 VAL A O     1 
ATOM   1236 C  CB    . VAL A 1 159 ? 0.513   -25.448 -2.878  1.00 89.95  ? 168 VAL A CB    1 
ATOM   1237 C  CG1   . VAL A 1 159 ? 1.142   -24.458 -1.905  1.00 91.02  ? 168 VAL A CG1   1 
ATOM   1238 C  CG2   . VAL A 1 159 ? -0.578  -24.755 -3.687  1.00 86.80  ? 168 VAL A CG2   1 
ATOM   1239 N  N     . ALA A 1 160 ? 3.752   -26.187 -2.657  1.00 98.52  ? 169 ALA A N     1 
ATOM   1240 C  CA    . ALA A 1 160 ? 4.899   -26.779 -1.923  1.00 100.93 ? 169 ALA A CA    1 
ATOM   1241 C  C     . ALA A 1 160 ? 5.616   -25.685 -1.134  1.00 102.44 ? 169 ALA A C     1 
ATOM   1242 O  O     . ALA A 1 160 ? 6.279   -24.882 -1.810  1.00 105.09 ? 169 ALA A O     1 
ATOM   1243 C  CB    . ALA A 1 160 ? 5.838   -27.462 -2.891  1.00 96.57  ? 169 ALA A CB    1 
ATOM   1244 N  N     . CYS A 1 168 ? 1.335   -30.350 -1.000  1.00 82.90  ? 177 CYS A N     1 
ATOM   1245 C  CA    . CYS A 1 168 ? -0.078  -30.491 -0.549  1.00 79.00  ? 177 CYS A CA    1 
ATOM   1246 C  C     . CYS A 1 168 ? -0.655  -31.837 -1.012  1.00 80.56  ? 177 CYS A C     1 
ATOM   1247 O  O     . CYS A 1 168 ? -1.097  -32.649 -0.157  1.00 61.25  ? 177 CYS A O     1 
ATOM   1248 C  CB    . CYS A 1 168 ? -0.932  -29.348 -1.088  1.00 82.76  ? 177 CYS A CB    1 
ATOM   1249 S  SG    . CYS A 1 168 ? -2.687  -29.482 -0.645  1.00 84.93  ? 177 CYS A SG    1 
ATOM   1250 N  N     . ARG A 1 169 ? -0.681  -32.041 -2.334  1.00 86.92  ? 178 ARG A N     1 
ATOM   1251 C  CA    . ARG A 1 169 ? -1.152  -33.285 -2.998  1.00 84.75  ? 178 ARG A CA    1 
ATOM   1252 C  C     . ARG A 1 169 ? -2.630  -33.529 -2.633  1.00 87.73  ? 178 ARG A C     1 
ATOM   1253 O  O     . ARG A 1 169 ? -3.044  -34.700 -2.582  1.00 77.67  ? 178 ARG A O     1 
ATOM   1254 C  CB    . ARG A 1 169 ? -0.204  -34.430 -2.621  1.00 81.63  ? 178 ARG A CB    1 
ATOM   1255 C  CG    . ARG A 1 169 ? 1.276   -34.079 -2.746  1.00 82.14  ? 178 ARG A CG    1 
ATOM   1256 C  CD    . ARG A 1 169 ? 2.224   -35.234 -2.473  1.00 80.45  ? 178 ARG A CD    1 
ATOM   1257 N  NE    . ARG A 1 169 ? 1.840   -36.441 -3.211  1.00 85.22  ? 178 ARG A NE    1 
ATOM   1258 C  CZ    . ARG A 1 169 ? 2.057   -36.659 -4.509  1.00 79.58  ? 178 ARG A CZ    1 
ATOM   1259 N  NH1   . ARG A 1 169 ? 2.657   -35.751 -5.266  1.00 79.76  ? 178 ARG A NH1   1 
ATOM   1260 N  NH2   . ARG A 1 169 ? 1.643   -37.786 -5.051  1.00 74.88  ? 178 ARG A NH2   1 
ATOM   1261 N  N     . GLY A 1 170 ? -3.403  -32.453 -2.426  1.00 83.10  ? 179 GLY A N     1 
ATOM   1262 C  CA    . GLY A 1 170 ? -4.827  -32.513 -2.040  1.00 80.19  ? 179 GLY A CA    1 
ATOM   1263 C  C     . GLY A 1 170 ? -5.709  -32.744 -3.254  1.00 74.02  ? 179 GLY A C     1 
ATOM   1264 O  O     . GLY A 1 170 ? -5.198  -32.689 -4.387  1.00 73.53  ? 179 GLY A O     1 
ATOM   1265 N  N     . GLU A 1 171 ? -6.992  -33.001 -3.032  1.00 58.56  ? 180 GLU A N     1 
ATOM   1266 C  CA    . GLU A 1 171 ? -7.921  -33.400 -4.109  1.00 58.32  ? 180 GLU A CA    1 
ATOM   1267 C  C     . GLU A 1 171 ? -8.421  -32.153 -4.838  1.00 60.03  ? 180 GLU A C     1 
ATOM   1268 O  O     . GLU A 1 171 ? -8.937  -31.256 -4.167  1.00 59.40  ? 180 GLU A O     1 
ATOM   1269 C  CB    . GLU A 1 171 ? -9.103  -34.149 -3.516  1.00 66.63  ? 180 GLU A CB    1 
ATOM   1270 C  CG    . GLU A 1 171 ? -9.580  -35.311 -4.355  1.00 69.94  ? 180 GLU A CG    1 
ATOM   1271 C  CD    . GLU A 1 171 ? -10.704 -36.003 -3.612  1.00 74.00  ? 180 GLU A CD    1 
ATOM   1272 O  OE1   . GLU A 1 171 ? -11.858 -35.494 -3.657  1.00 79.99  ? 180 GLU A OE1   1 
ATOM   1273 O  OE2   . GLU A 1 171 ? -10.396 -36.967 -2.897  1.00 70.41  ? 180 GLU A OE2   1 
ATOM   1274 N  N     . LEU A 1 172 ? -8.293  -32.107 -6.164  1.00 56.75  ? 181 LEU A N     1 
ATOM   1275 C  CA    . LEU A 1 172 ? -8.892  -31.022 -6.977  1.00 51.13  ? 181 LEU A CA    1 
ATOM   1276 C  C     . LEU A 1 172 ? -10.338 -31.381 -7.296  1.00 51.29  ? 181 LEU A C     1 
ATOM   1277 O  O     . LEU A 1 172 ? -10.624 -32.570 -7.558  1.00 46.31  ? 181 LEU A O     1 
ATOM   1278 C  CB    . LEU A 1 172 ? -8.077  -30.832 -8.251  1.00 54.07  ? 181 LEU A CB    1 
ATOM   1279 C  CG    . LEU A 1 172 ? -6.641  -30.354 -8.028  1.00 52.71  ? 181 LEU A CG    1 
ATOM   1280 C  CD1   . LEU A 1 172 ? -6.072  -29.851 -9.339  1.00 51.71  ? 181 LEU A CD1   1 
ATOM   1281 C  CD2   . LEU A 1 172 ? -6.555  -29.260 -6.963  1.00 51.70  ? 181 LEU A CD2   1 
ATOM   1282 N  N     . ARG A 1 173 ? -11.211 -30.380 -7.259  1.00 51.62  ? 182 ARG A N     1 
ATOM   1283 C  CA    . ARG A 1 173 ? -12.658 -30.546 -7.517  1.00 56.96  ? 182 ARG A CA    1 
ATOM   1284 C  C     . ARG A 1 173 ? -13.144 -29.418 -8.421  1.00 59.94  ? 182 ARG A C     1 
ATOM   1285 O  O     . ARG A 1 173 ? -12.572 -28.305 -8.331  1.00 58.96  ? 182 ARG A O     1 
ATOM   1286 C  CB    . ARG A 1 173 ? -13.414 -30.517 -6.192  1.00 61.91  ? 182 ARG A CB    1 
ATOM   1287 C  CG    . ARG A 1 173 ? -13.021 -31.649 -5.257  1.00 73.75  ? 182 ARG A CG    1 
ATOM   1288 C  CD    . ARG A 1 173 ? -14.083 -31.933 -4.219  1.00 77.68  ? 182 ARG A CD    1 
ATOM   1289 N  NE    . ARG A 1 173 ? -13.536 -32.768 -3.162  1.00 82.90  ? 182 ARG A NE    1 
ATOM   1290 C  CZ    . ARG A 1 173 ? -14.098 -32.946 -1.975  1.00 82.14  ? 182 ARG A CZ    1 
ATOM   1291 N  NH1   . ARG A 1 173 ? -15.241 -32.351 -1.675  1.00 78.03  ? 182 ARG A NH1   1 
ATOM   1292 N  NH2   . ARG A 1 173 ? -13.504 -33.717 -1.086  1.00 87.92  ? 182 ARG A NH2   1 
ATOM   1293 N  N     . ASP A 1 174 ? -14.196 -29.677 -9.201  1.00 54.11  ? 183 ASP A N     1 
ATOM   1294 C  CA    . ASP A 1 174 ? -14.938 -28.643 -9.967  1.00 52.47  ? 183 ASP A CA    1 
ATOM   1295 C  C     . ASP A 1 174 ? -15.583 -27.629 -9.008  1.00 53.59  ? 183 ASP A C     1 
ATOM   1296 O  O     . ASP A 1 174 ? -15.759 -27.940 -7.809  1.00 60.23  ? 183 ASP A O     1 
ATOM   1297 C  CB    . ASP A 1 174 ? -15.983 -29.291 -10.872 1.00 56.06  ? 183 ASP A CB    1 
ATOM   1298 C  CG    . ASP A 1 174 ? -17.127 -29.958 -10.129 1.00 58.18  ? 183 ASP A CG    1 
ATOM   1299 O  OD1   . ASP A 1 174 ? -18.109 -29.265 -9.800  1.00 58.72  ? 183 ASP A OD1   1 
ATOM   1300 O  OD2   . ASP A 1 174 ? -17.031 -31.173 -9.902  1.00 69.00  ? 183 ASP A OD2   1 
ATOM   1301 N  N     . THR A 1 175 ? -15.962 -26.456 -9.512  1.00 51.40  ? 184 THR A N     1 
ATOM   1302 C  CA    . THR A 1 175 ? -16.671 -25.416 -8.711  1.00 51.42  ? 184 THR A CA    1 
ATOM   1303 C  C     . THR A 1 175 ? -18.134 -25.282 -9.169  1.00 48.64  ? 184 THR A C     1 
ATOM   1304 O  O     . THR A 1 175 ? -18.802 -24.318 -8.748  1.00 38.38  ? 184 THR A O     1 
ATOM   1305 C  CB    . THR A 1 175 ? -15.884 -24.102 -8.744  1.00 46.69  ? 184 THR A CB    1 
ATOM   1306 O  OG1   . THR A 1 175 ? -15.464 -23.835 -10.080 1.00 41.06  ? 184 THR A OG1   1 
ATOM   1307 C  CG2   . THR A 1 175 ? -14.671 -24.170 -7.846  1.00 48.78  ? 184 THR A CG2   1 
ATOM   1308 N  N     . ILE A 1 176 ? -18.642 -26.208 -9.978  1.00 49.44  ? 185 ILE A N     1 
ATOM   1309 C  CA    . ILE A 1 176 ? -20.036 -26.077 -10.508 1.00 51.37  ? 185 ILE A CA    1 
ATOM   1310 C  C     . ILE A 1 176 ? -20.979 -26.564 -9.416  1.00 47.28  ? 185 ILE A C     1 
ATOM   1311 O  O     . ILE A 1 176 ? -21.001 -27.776 -9.214  1.00 45.08  ? 185 ILE A O     1 
ATOM   1312 C  CB    . ILE A 1 176 ? -20.242 -26.869 -11.813 1.00 51.50  ? 185 ILE A CB    1 
ATOM   1313 C  CG1   . ILE A 1 176 ? -19.179 -26.514 -12.850 1.00 56.38  ? 185 ILE A CG1   1 
ATOM   1314 C  CG2   . ILE A 1 176 ? -21.655 -26.703 -12.355 1.00 46.34  ? 185 ILE A CG2   1 
ATOM   1315 C  CD1   . ILE A 1 176 ? -19.223 -25.076 -13.264 1.00 59.57  ? 185 ILE A CD1   1 
ATOM   1316 N  N     . LEU A 1 177 ? -21.674 -25.640 -8.748  1.00 44.97  ? 186 LEU A N     1 
ATOM   1317 C  CA    . LEU A 1 177 ? -22.786 -25.914 -7.798  1.00 54.08  ? 186 LEU A CA    1 
ATOM   1318 C  C     . LEU A 1 177 ? -23.796 -26.903 -8.393  1.00 53.93  ? 186 LEU A C     1 
ATOM   1319 O  O     . LEU A 1 177 ? -24.075 -26.850 -9.618  1.00 50.47  ? 186 LEU A O     1 
ATOM   1320 C  CB    . LEU A 1 177 ? -23.525 -24.610 -7.467  1.00 52.69  ? 186 LEU A CB    1 
ATOM   1321 C  CG    . LEU A 1 177 ? -22.743 -23.565 -6.678  1.00 53.26  ? 186 LEU A CG    1 
ATOM   1322 C  CD1   . LEU A 1 177 ? -23.698 -22.637 -5.961  1.00 52.83  ? 186 LEU A CD1   1 
ATOM   1323 C  CD2   . LEU A 1 177 ? -21.789 -24.199 -5.681  1.00 50.06  ? 186 LEU A CD2   1 
ATOM   1324 N  N     . ASP A 1 178 ? -24.373 -27.733 -7.528  1.00 61.54  ? 187 ASP A N     1 
ATOM   1325 C  CA    . ASP A 1 178 ? -25.532 -28.594 -7.866  1.00 68.15  ? 187 ASP A CA    1 
ATOM   1326 C  C     . ASP A 1 178 ? -26.785 -27.940 -7.285  1.00 67.90  ? 187 ASP A C     1 
ATOM   1327 O  O     . ASP A 1 178 ? -26.651 -26.880 -6.632  1.00 58.88  ? 187 ASP A O     1 
ATOM   1328 C  CB    . ASP A 1 178 ? -25.330 -30.009 -7.336  1.00 76.32  ? 187 ASP A CB    1 
ATOM   1329 C  CG    . ASP A 1 178 ? -26.001 -31.056 -8.199  1.00 87.55  ? 187 ASP A CG    1 
ATOM   1330 O  OD1   . ASP A 1 178 ? -26.770 -30.667 -9.099  1.00 90.52  ? 187 ASP A OD1   1 
ATOM   1331 O  OD2   . ASP A 1 178 ? -25.745 -32.250 -7.962  1.00 106.56 ? 187 ASP A OD2   1 
ATOM   1332 N  N     . TRP A 1 179 ? -27.944 -28.572 -7.476  1.00 62.86  ? 188 TRP A N     1 
ATOM   1333 C  CA    . TRP A 1 179 ? -29.252 -28.001 -7.062  1.00 66.13  ? 188 TRP A CA    1 
ATOM   1334 C  C     . TRP A 1 179 ? -29.311 -27.741 -5.556  1.00 60.29  ? 188 TRP A C     1 
ATOM   1335 O  O     . TRP A 1 179 ? -29.964 -26.785 -5.204  1.00 67.71  ? 188 TRP A O     1 
ATOM   1336 C  CB    . TRP A 1 179 ? -30.423 -28.854 -7.551  1.00 62.44  ? 188 TRP A CB    1 
ATOM   1337 C  CG    . TRP A 1 179 ? -30.680 -28.597 -9.000  1.00 71.85  ? 188 TRP A CG    1 
ATOM   1338 C  CD1   . TRP A 1 179 ? -30.377 -29.419 -10.047 1.00 73.53  ? 188 TRP A CD1   1 
ATOM   1339 C  CD2   . TRP A 1 179 ? -31.194 -27.376 -9.579  1.00 72.73  ? 188 TRP A CD2   1 
ATOM   1340 N  NE1   . TRP A 1 179 ? -30.711 -28.817 -11.234 1.00 77.17  ? 188 TRP A NE1   1 
ATOM   1341 C  CE2   . TRP A 1 179 ? -31.208 -27.562 -10.982 1.00 73.95  ? 188 TRP A CE2   1 
ATOM   1342 C  CE3   . TRP A 1 179 ? -31.667 -26.162 -9.058  1.00 67.15  ? 188 TRP A CE3   1 
ATOM   1343 C  CZ2   . TRP A 1 179 ? -31.685 -26.583 -11.856 1.00 68.72  ? 188 TRP A CZ2   1 
ATOM   1344 C  CZ3   . TRP A 1 179 ? -32.139 -25.197 -9.925  1.00 66.05  ? 188 TRP A CZ3   1 
ATOM   1345 C  CH2   . TRP A 1 179 ? -32.149 -25.407 -11.304 1.00 63.96  ? 188 TRP A CH2   1 
ATOM   1346 N  N     . GLU A 1 180 ? -28.691 -28.548 -4.698  1.00 61.71  ? 189 GLU A N     1 
ATOM   1347 C  CA    . GLU A 1 180 ? -28.911 -28.402 -3.233  1.00 63.91  ? 189 GLU A CA    1 
ATOM   1348 C  C     . GLU A 1 180 ? -27.729 -27.642 -2.622  1.00 61.21  ? 189 GLU A C     1 
ATOM   1349 O  O     . GLU A 1 180 ? -27.796 -27.318 -1.436  1.00 52.77  ? 189 GLU A O     1 
ATOM   1350 C  CB    . GLU A 1 180 ? -29.146 -29.769 -2.580  1.00 75.01  ? 189 GLU A CB    1 
ATOM   1351 C  CG    . GLU A 1 180 ? -27.942 -30.352 -1.853  1.00 76.44  ? 189 GLU A CG    1 
ATOM   1352 C  CD    . GLU A 1 180 ? -26.801 -30.874 -2.716  1.00 78.54  ? 189 GLU A CD    1 
ATOM   1353 O  OE1   . GLU A 1 180 ? -27.028 -31.139 -3.913  1.00 79.09  ? 189 GLU A OE1   1 
ATOM   1354 O  OE2   . GLU A 1 180 ? -25.681 -31.045 -2.170  1.00 75.45  ? 189 GLU A OE2   1 
ATOM   1355 N  N     . ASP A 1 181 ? -26.696 -27.370 -3.421  1.00 61.45  ? 190 ASP A N     1 
ATOM   1356 C  CA    . ASP A 1 181 ? -25.397 -26.794 -2.983  1.00 57.12  ? 190 ASP A CA    1 
ATOM   1357 C  C     . ASP A 1 181 ? -25.543 -25.322 -2.596  1.00 57.41  ? 190 ASP A C     1 
ATOM   1358 O  O     . ASP A 1 181 ? -26.131 -24.582 -3.408  1.00 49.69  ? 190 ASP A O     1 
ATOM   1359 C  CB    . ASP A 1 181 ? -24.382 -26.906 -4.113  1.00 56.98  ? 190 ASP A CB    1 
ATOM   1360 C  CG    . ASP A 1 181 ? -23.675 -28.235 -4.083  1.00 54.15  ? 190 ASP A CG    1 
ATOM   1361 O  OD1   . ASP A 1 181 ? -23.361 -28.662 -2.975  1.00 62.77  ? 190 ASP A OD1   1 
ATOM   1362 O  OD2   . ASP A 1 181 ? -23.484 -28.834 -5.149  1.00 51.75  ? 190 ASP A OD2   1 
ATOM   1363 N  N     . SER A 1 182 ? -24.990 -24.916 -1.443  1.00 56.83  ? 191 SER A N     1 
ATOM   1364 C  CA    . SER A 1 182 ? -24.907 -23.488 -1.011  1.00 57.63  ? 191 SER A CA    1 
ATOM   1365 C  C     . SER A 1 182 ? -23.938 -22.752 -1.940  1.00 58.19  ? 191 SER A C     1 
ATOM   1366 O  O     . SER A 1 182 ? -23.068 -23.400 -2.553  1.00 54.87  ? 191 SER A O     1 
ATOM   1367 C  CB    . SER A 1 182 ? -24.446 -23.249 0.429   1.00 54.97  ? 191 SER A CB    1 
ATOM   1368 O  OG    . SER A 1 182 ? -24.589 -24.366 1.280   1.00 57.78  ? 191 SER A OG    1 
ATOM   1369 N  N     . LEU A 1 183 ? -24.064 -21.431 -1.985  1.00 60.24  ? 192 LEU A N     1 
ATOM   1370 C  CA    . LEU A 1 183 ? -23.144 -20.529 -2.715  1.00 59.57  ? 192 LEU A CA    1 
ATOM   1371 C  C     . LEU A 1 183 ? -21.820 -20.471 -1.955  1.00 62.97  ? 192 LEU A C     1 
ATOM   1372 O  O     . LEU A 1 183 ? -21.812 -20.453 -0.721  1.00 69.32  ? 192 LEU A O     1 
ATOM   1373 C  CB    . LEU A 1 183 ? -23.790 -19.146 -2.814  1.00 60.62  ? 192 LEU A CB    1 
ATOM   1374 C  CG    . LEU A 1 183 ? -24.384 -18.778 -4.167  1.00 67.93  ? 192 LEU A CG    1 
ATOM   1375 C  CD1   . LEU A 1 183 ? -25.480 -19.745 -4.575  1.00 67.09  ? 192 LEU A CD1   1 
ATOM   1376 C  CD2   . LEU A 1 183 ? -24.907 -17.353 -4.141  1.00 69.09  ? 192 LEU A CD2   1 
ATOM   1377 N  N     . PRO A 1 184 ? -20.663 -20.426 -2.651  1.00 62.25  ? 193 PRO A N     1 
ATOM   1378 C  CA    . PRO A 1 184 ? -19.392 -20.089 -2.007  1.00 59.32  ? 193 PRO A CA    1 
ATOM   1379 C  C     . PRO A 1 184 ? -19.545 -18.793 -1.197  1.00 62.19  ? 193 PRO A C     1 
ATOM   1380 O  O     . PRO A 1 184 ? -20.052 -17.790 -1.732  1.00 52.82  ? 193 PRO A O     1 
ATOM   1381 C  CB    . PRO A 1 184 ? -18.418 -19.903 -3.184  1.00 61.38  ? 193 PRO A CB    1 
ATOM   1382 C  CG    . PRO A 1 184 ? -19.314 -19.711 -4.396  1.00 57.35  ? 193 PRO A CG    1 
ATOM   1383 C  CD    . PRO A 1 184 ? -20.514 -20.587 -4.108  1.00 60.04  ? 193 PRO A CD    1 
ATOM   1384 N  N     . ASP A 1 185 ? -19.148 -18.859 0.075   1.00 66.82  ? 194 ASP A N     1 
ATOM   1385 C  CA    . ASP A 1 185 ? -19.463 -17.850 1.118   1.00 64.16  ? 194 ASP A CA    1 
ATOM   1386 C  C     . ASP A 1 185 ? -18.729 -16.569 0.789   1.00 59.95  ? 194 ASP A C     1 
ATOM   1387 O  O     . ASP A 1 185 ? -19.314 -15.514 1.020   1.00 64.52  ? 194 ASP A O     1 
ATOM   1388 C  CB    . ASP A 1 185 ? -19.055 -18.306 2.518   1.00 70.05  ? 194 ASP A CB    1 
ATOM   1389 C  CG    . ASP A 1 185 ? -19.662 -19.640 2.887   1.00 72.31  ? 194 ASP A CG    1 
ATOM   1390 O  OD1   . ASP A 1 185 ? -20.007 -20.388 1.957   1.00 78.10  ? 194 ASP A OD1   1 
ATOM   1391 O  OD2   . ASP A 1 185 ? -19.792 -19.910 4.092   1.00 79.95  ? 194 ASP A OD2   1 
ATOM   1392 N  N     . ARG A 1 186 ? -17.502 -16.686 0.276   1.00 64.43  ? 195 ARG A N     1 
ATOM   1393 C  CA    . ARG A 1 186 ? -16.637 -15.522 -0.052  1.00 64.73  ? 195 ARG A CA    1 
ATOM   1394 C  C     . ARG A 1 186 ? -17.266 -14.700 -1.184  1.00 59.01  ? 195 ARG A C     1 
ATOM   1395 O  O     . ARG A 1 186 ? -17.335 -13.471 -1.052  1.00 52.06  ? 195 ARG A O     1 
ATOM   1396 C  CB    . ARG A 1 186 ? -15.245 -16.000 -0.450  1.00 76.60  ? 195 ARG A CB    1 
ATOM   1397 C  CG    . ARG A 1 186 ? -14.277 -14.863 -0.724  1.00 80.33  ? 195 ARG A CG    1 
ATOM   1398 C  CD    . ARG A 1 186 ? -12.894 -15.376 -1.071  1.00 83.86  ? 195 ARG A CD    1 
ATOM   1399 N  NE    . ARG A 1 186 ? -12.024 -14.235 -1.320  1.00 97.17  ? 195 ARG A NE    1 
ATOM   1400 C  CZ    . ARG A 1 186 ? -12.082 -13.457 -2.402  1.00 99.32  ? 195 ARG A CZ    1 
ATOM   1401 N  NH1   . ARG A 1 186 ? -12.964 -13.701 -3.363  1.00 99.50  ? 195 ARG A NH1   1 
ATOM   1402 N  NH2   . ARG A 1 186 ? -11.260 -12.426 -2.510  1.00 96.64  ? 195 ARG A NH2   1 
ATOM   1403 N  N     . ASP A 1 187 ? -17.668 -15.354 -2.276  1.00 61.15  ? 196 ASP A N     1 
ATOM   1404 C  CA    . ASP A 1 187 ? -18.221 -14.662 -3.470  1.00 62.11  ? 196 ASP A CA    1 
ATOM   1405 C  C     . ASP A 1 187 ? -19.569 -14.059 -3.092  1.00 58.45  ? 196 ASP A C     1 
ATOM   1406 O  O     . ASP A 1 187 ? -19.778 -12.886 -3.392  1.00 57.73  ? 196 ASP A O     1 
ATOM   1407 C  CB    . ASP A 1 187 ? -18.345 -15.583 -4.679  1.00 69.64  ? 196 ASP A CB    1 
ATOM   1408 C  CG    . ASP A 1 187 ? -16.990 -15.903 -5.267  1.00 74.00  ? 196 ASP A CG    1 
ATOM   1409 O  OD1   . ASP A 1 187 ? -16.087 -16.221 -4.468  1.00 85.77  ? 196 ASP A OD1   1 
ATOM   1410 O  OD2   . ASP A 1 187 ? -16.837 -15.779 -6.496  1.00 68.60  ? 196 ASP A OD2   1 
ATOM   1411 N  N     . LEU A 1 188 ? -20.422 -14.819 -2.416  1.00 53.68  ? 197 LEU A N     1 
ATOM   1412 C  CA    . LEU A 1 188 ? -21.717 -14.286 -1.962  1.00 48.08  ? 197 LEU A CA    1 
ATOM   1413 C  C     . LEU A 1 188 ? -21.482 -13.082 -1.055  1.00 50.67  ? 197 LEU A C     1 
ATOM   1414 O  O     . LEU A 1 188 ? -22.165 -12.058 -1.250  1.00 56.34  ? 197 LEU A O     1 
ATOM   1415 C  CB    . LEU A 1 188 ? -22.489 -15.337 -1.177  1.00 56.71  ? 197 LEU A CB    1 
ATOM   1416 C  CG    . LEU A 1 188 ? -23.860 -14.842 -0.726  1.00 50.30  ? 197 LEU A CG    1 
ATOM   1417 C  CD1   . LEU A 1 188 ? -24.637 -14.315 -1.925  1.00 51.83  ? 197 LEU A CD1   1 
ATOM   1418 C  CD2   . LEU A 1 188 ? -24.632 -15.953 -0.028  1.00 50.79  ? 197 LEU A CD2   1 
ATOM   1419 N  N     . ALA A 1 189 ? -20.607 -13.205 -0.061  1.00 45.12  ? 198 ALA A N     1 
ATOM   1420 C  CA    . ALA A 1 189 ? -20.349 -12.097 0.892   1.00 49.44  ? 198 ALA A CA    1 
ATOM   1421 C  C     . ALA A 1 189 ? -19.940 -10.834 0.125   1.00 49.42  ? 198 ALA A C     1 
ATOM   1422 O  O     . ALA A 1 189 ? -20.536 -9.792  0.403   1.00 46.30  ? 198 ALA A O     1 
ATOM   1423 C  CB    . ALA A 1 189 ? -19.307 -12.467 1.916   1.00 53.29  ? 198 ALA A CB    1 
ATOM   1424 N  N     . LEU A 1 190 ? -18.965 -10.917 -0.793  1.00 56.23  ? 199 LEU A N     1 
ATOM   1425 C  CA    . LEU A 1 190 ? -18.473 -9.728  -1.555  1.00 55.30  ? 199 LEU A CA    1 
ATOM   1426 C  C     . LEU A 1 190 ? -19.604 -9.185  -2.427  1.00 54.76  ? 199 LEU A C     1 
ATOM   1427 O  O     . LEU A 1 190 ? -19.769 -7.950  -2.462  1.00 54.48  ? 199 LEU A O     1 
ATOM   1428 C  CB    . LEU A 1 190 ? -17.255 -10.097 -2.413  1.00 61.03  ? 199 LEU A CB    1 
ATOM   1429 C  CG    . LEU A 1 190 ? -15.996 -10.487 -1.634  1.00 56.71  ? 199 LEU A CG    1 
ATOM   1430 C  CD1   . LEU A 1 190 ? -14.934 -11.060 -2.558  1.00 62.56  ? 199 LEU A CD1   1 
ATOM   1431 C  CD2   . LEU A 1 190 ? -15.440 -9.303  -0.875  1.00 51.88  ? 199 LEU A CD2   1 
ATOM   1432 N  N     . ALA A 1 191 ? -20.361 -10.075 -3.086  1.00 53.22  ? 200 ALA A N     1 
ATOM   1433 C  CA    . ALA A 1 191 ? -21.503 -9.700  -3.958  1.00 52.67  ? 200 ALA A CA    1 
ATOM   1434 C  C     . ALA A 1 191 ? -22.558 -8.965  -3.120  1.00 52.33  ? 200 ALA A C     1 
ATOM   1435 O  O     . ALA A 1 191 ? -23.070 -7.950  -3.580  1.00 48.88  ? 200 ALA A O     1 
ATOM   1436 C  CB    . ALA A 1 191 ? -22.077 -10.905 -4.647  1.00 45.77  ? 200 ALA A CB    1 
ATOM   1437 N  N     . ASP A 1 192 ? -22.846 -9.448  -1.912  1.00 60.59  ? 201 ASP A N     1 
ATOM   1438 C  CA    . ASP A 1 192 ? -23.862 -8.848  -0.997  1.00 52.65  ? 201 ASP A CA    1 
ATOM   1439 C  C     . ASP A 1 192 ? -23.389 -7.463  -0.539  1.00 45.32  ? 201 ASP A C     1 
ATOM   1440 O  O     . ASP A 1 192 ? -24.176 -6.532  -0.537  1.00 41.34  ? 201 ASP A O     1 
ATOM   1441 C  CB    . ASP A 1 192 ? -24.105 -9.763  0.200   1.00 58.65  ? 201 ASP A CB    1 
ATOM   1442 C  CG    . ASP A 1 192 ? -25.136 -9.219  1.165   1.00 60.18  ? 201 ASP A CG    1 
ATOM   1443 O  OD1   . ASP A 1 192 ? -26.296 -9.523  0.945   1.00 61.16  ? 201 ASP A OD1   1 
ATOM   1444 O  OD2   . ASP A 1 192 ? -24.757 -8.494  2.128   1.00 65.96  ? 201 ASP A OD2   1 
ATOM   1445 N  N     . GLU A 1 193 ? -22.128 -7.340  -0.151  1.00 50.87  ? 202 GLU A N     1 
ATOM   1446 C  CA    . GLU A 1 193 ? -21.523 -6.042  0.251   1.00 54.82  ? 202 GLU A CA    1 
ATOM   1447 C  C     . GLU A 1 193 ? -21.594 -5.064  -0.935  1.00 47.86  ? 202 GLU A C     1 
ATOM   1448 O  O     . GLU A 1 193 ? -22.150 -3.984  -0.784  1.00 50.49  ? 202 GLU A O     1 
ATOM   1449 C  CB    . GLU A 1 193 ? -20.082 -6.259  0.717   1.00 57.38  ? 202 GLU A CB    1 
ATOM   1450 C  CG    . GLU A 1 193 ? -19.444 -5.027  1.345   1.00 62.24  ? 202 GLU A CG    1 
ATOM   1451 C  CD    . GLU A 1 193 ? -18.003 -4.814  0.897   1.00 78.03  ? 202 GLU A CD    1 
ATOM   1452 O  OE1   . GLU A 1 193 ? -17.111 -5.469  1.473   1.00 89.02  ? 202 GLU A OE1   1 
ATOM   1453 O  OE2   . GLU A 1 193 ? -17.775 -4.026  -0.064  1.00 66.90  ? 202 GLU A OE2   1 
ATOM   1454 N  N     . ALA A 1 194 ? -21.078 -5.450  -2.093  1.00 49.70  ? 203 ALA A N     1 
ATOM   1455 C  CA    . ALA A 1 194 ? -21.039 -4.582  -3.296  1.00 49.88  ? 203 ALA A CA    1 
ATOM   1456 C  C     . ALA A 1 194 ? -22.453 -4.143  -3.691  1.00 50.99  ? 203 ALA A C     1 
ATOM   1457 O  O     . ALA A 1 194 ? -22.636 -2.968  -4.079  1.00 50.67  ? 203 ALA A O     1 
ATOM   1458 C  CB    . ALA A 1 194 ? -20.372 -5.302  -4.424  1.00 47.77  ? 203 ALA A CB    1 
ATOM   1459 N  N     . SER A 1 195 ? -23.423 -5.040  -3.601  1.00 44.62  ? 204 SER A N     1 
ATOM   1460 C  CA    . SER A 1 195 ? -24.836 -4.733  -3.943  1.00 49.39  ? 204 SER A CA    1 
ATOM   1461 C  C     . SER A 1 195 ? -25.432 -3.781  -2.895  1.00 49.28  ? 204 SER A C     1 
ATOM   1462 O  O     . SER A 1 195 ? -26.090 -2.802  -3.289  1.00 43.62  ? 204 SER A O     1 
ATOM   1463 C  CB    . SER A 1 195 ? -25.607 -6.011  -4.089  1.00 51.17  ? 204 SER A CB    1 
ATOM   1464 O  OG    . SER A 1 195 ? -25.298 -6.636  -5.340  1.00 49.08  ? 204 SER A OG    1 
ATOM   1465 N  N     . ARG A 1 196 ? -25.171 -4.050  -1.611  1.00 54.03  ? 205 ARG A N     1 
ATOM   1466 C  CA    . ARG A 1 196 ? -25.679 -3.252  -0.461  1.00 63.40  ? 205 ARG A CA    1 
ATOM   1467 C  C     . ARG A 1 196 ? -25.234 -1.794  -0.595  1.00 51.95  ? 205 ARG A C     1 
ATOM   1468 O  O     . ARG A 1 196 ? -26.052 -0.922  -0.421  1.00 51.55  ? 205 ARG A O     1 
ATOM   1469 C  CB    . ARG A 1 196 ? -25.148 -3.766  0.881   1.00 74.93  ? 205 ARG A CB    1 
ATOM   1470 C  CG    . ARG A 1 196 ? -25.999 -4.847  1.535   1.00 80.35  ? 205 ARG A CG    1 
ATOM   1471 C  CD    . ARG A 1 196 ? -25.549 -5.189  2.953   1.00 80.26  ? 205 ARG A CD    1 
ATOM   1472 N  NE    . ARG A 1 196 ? -24.435 -6.134  3.015   1.00 80.36  ? 205 ARG A NE    1 
ATOM   1473 C  CZ    . ARG A 1 196 ? -23.164 -5.816  3.270   1.00 84.44  ? 205 ARG A CZ    1 
ATOM   1474 N  NH1   . ARG A 1 196 ? -22.820 -4.562  3.507   1.00 80.71  ? 205 ARG A NH1   1 
ATOM   1475 N  NH2   . ARG A 1 196 ? -22.235 -6.760  3.299   1.00 77.16  ? 205 ARG A NH2   1 
ATOM   1476 N  N     . ASN A 1 197 ? -23.970 -1.541  -0.872  1.00 53.64  ? 206 ASN A N     1 
ATOM   1477 C  CA    . ASN A 1 197 ? -23.425 -0.159  -0.804  1.00 55.22  ? 206 ASN A CA    1 
ATOM   1478 C  C     . ASN A 1 197 ? -23.351 0.467   -2.202  1.00 57.49  ? 206 ASN A C     1 
ATOM   1479 O  O     . ASN A 1 197 ? -22.782 1.545   -2.291  1.00 55.76  ? 206 ASN A O     1 
ATOM   1480 C  CB    . ASN A 1 197 ? -22.125 -0.181  -0.007  1.00 63.80  ? 206 ASN A CB    1 
ATOM   1481 C  CG    . ASN A 1 197 ? -22.369 -0.765  1.377   1.00 73.03  ? 206 ASN A CG    1 
ATOM   1482 O  OD1   . ASN A 1 197 ? -23.343 -0.404  2.053   1.00 63.65  ? 206 ASN A OD1   1 
ATOM   1483 N  ND2   . ASN A 1 197 ? -21.533 -1.708  1.793   1.00 70.58  ? 206 ASN A ND2   1 
ATOM   1484 N  N     . ALA A 1 198 ? -23.966 -0.135  -3.234  1.00 53.94  ? 207 ALA A N     1 
ATOM   1485 C  CA    . ALA A 1 198 ? -24.036 0.440   -4.598  1.00 56.01  ? 207 ALA A CA    1 
ATOM   1486 C  C     . ALA A 1 198 ? -25.130 1.517   -4.628  1.00 58.38  ? 207 ALA A C     1 
ATOM   1487 O  O     . ALA A 1 198 ? -26.161 1.304   -3.997  1.00 59.71  ? 207 ALA A O     1 
ATOM   1488 C  CB    . ALA A 1 198 ? -24.336 -0.639  -5.613  1.00 51.17  ? 207 ALA A CB    1 
ATOM   1489 N  N     . ASP A 1 199 ? -24.951 2.589   -5.398  1.00 54.33  ? 208 ASP A N     1 
ATOM   1490 C  CA    . ASP A 1 199 ? -26.034 3.567   -5.676  1.00 54.71  ? 208 ASP A CA    1 
ATOM   1491 C  C     . ASP A 1 199 ? -26.624 3.308   -7.075  1.00 51.78  ? 208 ASP A C     1 
ATOM   1492 O  O     . ASP A 1 199 ? -27.632 3.981   -7.454  1.00 44.64  ? 208 ASP A O     1 
ATOM   1493 C  CB    . ASP A 1 199 ? -25.551 5.001   -5.450  1.00 56.62  ? 208 ASP A CB    1 
ATOM   1494 C  CG    . ASP A 1 199 ? -24.426 5.407   -6.376  1.00 64.09  ? 208 ASP A CG    1 
ATOM   1495 O  OD1   . ASP A 1 199 ? -24.434 4.932   -7.524  1.00 61.69  ? 208 ASP A OD1   1 
ATOM   1496 O  OD2   . ASP A 1 199 ? -23.529 6.162   -5.916  1.00 68.00  ? 208 ASP A OD2   1 
ATOM   1497 N  N     . LEU A 1 200 ? -26.092 2.323   -7.792  1.00 45.85  ? 209 LEU A N     1 
ATOM   1498 C  CA    . LEU A 1 200 ? -26.725 1.811   -9.022  1.00 41.35  ? 209 LEU A CA    1 
ATOM   1499 C  C     . LEU A 1 200 ? -26.359 0.335   -9.232  1.00 42.87  ? 209 LEU A C     1 
ATOM   1500 O  O     . LEU A 1 200 ? -25.159 -0.000  -9.261  1.00 41.80  ? 209 LEU A O     1 
ATOM   1501 C  CB    . LEU A 1 200 ? -26.208 2.675   -10.165 1.00 44.39  ? 209 LEU A CB    1 
ATOM   1502 C  CG    . LEU A 1 200 ? -26.746 2.340   -11.550 1.00 43.57  ? 209 LEU A CG    1 
ATOM   1503 C  CD1   . LEU A 1 200 ? -28.225 2.668   -11.605 1.00 43.35  ? 209 LEU A CD1   1 
ATOM   1504 C  CD2   . LEU A 1 200 ? -25.991 3.142   -12.600 1.00 48.35  ? 209 LEU A CD2   1 
ATOM   1505 N  N     . SER A 1 201 ? -27.356 -0.501  -9.453  1.00 40.25  ? 210 SER A N     1 
ATOM   1506 C  CA    . SER A 1 201 ? -27.199 -1.886  -9.959  1.00 41.44  ? 210 SER A CA    1 
ATOM   1507 C  C     . SER A 1 201 ? -27.770 -1.944  -11.370 1.00 36.62  ? 210 SER A C     1 
ATOM   1508 O  O     . SER A 1 201 ? -28.822 -1.383  -11.560 1.00 46.08  ? 210 SER A O     1 
ATOM   1509 C  CB    . SER A 1 201 ? -27.896 -2.846  -9.067  1.00 35.12  ? 210 SER A CB    1 
ATOM   1510 O  OG    . SER A 1 201 ? -27.081 -3.121  -7.982  1.00 35.48  ? 210 SER A OG    1 
ATOM   1511 N  N     . ILE A 1 202 ? -27.056 -2.523  -12.319 1.00 38.88  ? 211 ILE A N     1 
ATOM   1512 C  CA    . ILE A 1 202 ? -27.509 -2.746  -13.726 1.00 32.68  ? 211 ILE A CA    1 
ATOM   1513 C  C     . ILE A 1 202 ? -27.424 -4.249  -13.946 1.00 30.92  ? 211 ILE A C     1 
ATOM   1514 O  O     . ILE A 1 202 ? -26.335 -4.816  -13.724 1.00 32.78  ? 211 ILE A O     1 
ATOM   1515 C  CB    . ILE A 1 202 ? -26.631 -1.980  -14.732 1.00 35.36  ? 211 ILE A CB    1 
ATOM   1516 C  CG1   . ILE A 1 202 ? -26.605 -0.491  -14.420 1.00 37.76  ? 211 ILE A CG1   1 
ATOM   1517 C  CG2   . ILE A 1 202 ? -27.040 -2.242  -16.181 1.00 32.44  ? 211 ILE A CG2   1 
ATOM   1518 C  CD1   . ILE A 1 202 ? -25.402 0.224   -14.965 1.00 47.15  ? 211 ILE A CD1   1 
ATOM   1519 N  N     . THR A 1 203 ? -28.524 -4.887  -14.317 1.00 32.39  ? 212 THR A N     1 
ATOM   1520 C  CA    . THR A 1 203 ? -28.597 -6.341  -14.565 1.00 30.72  ? 212 THR A CA    1 
ATOM   1521 C  C     . THR A 1 203 ? -28.735 -6.582  -16.075 1.00 34.85  ? 212 THR A C     1 
ATOM   1522 O  O     . THR A 1 203 ? -29.651 -6.051  -16.674 1.00 37.58  ? 212 THR A O     1 
ATOM   1523 C  CB    . THR A 1 203 ? -29.767 -6.954  -13.813 1.00 34.72  ? 212 THR A CB    1 
ATOM   1524 O  OG1   . THR A 1 203 ? -30.919 -6.490  -14.509 1.00 37.27  ? 212 THR A OG1   1 
ATOM   1525 C  CG2   . THR A 1 203 ? -29.838 -6.545  -12.359 1.00 39.96  ? 212 THR A CG2   1 
ATOM   1526 N  N     . LEU A 1 204 ? -27.840 -7.375  -16.646 1.00 37.04  ? 213 LEU A N     1 
ATOM   1527 C  CA    . LEU A 1 204 ? -27.760 -7.658  -18.090 1.00 37.02  ? 213 LEU A CA    1 
ATOM   1528 C  C     . LEU A 1 204 ? -27.991 -9.166  -18.270 1.00 37.14  ? 213 LEU A C     1 
ATOM   1529 O  O     . LEU A 1 204 ? -27.377 -9.934  -17.541 1.00 37.63  ? 213 LEU A O     1 
ATOM   1530 C  CB    . LEU A 1 204 ? -26.381 -7.263  -18.631 1.00 33.46  ? 213 LEU A CB    1 
ATOM   1531 C  CG    . LEU A 1 204 ? -25.843 -5.875  -18.322 1.00 34.07  ? 213 LEU A CG    1 
ATOM   1532 C  CD1   . LEU A 1 204 ? -24.409 -5.813  -18.774 1.00 38.42  ? 213 LEU A CD1   1 
ATOM   1533 C  CD2   . LEU A 1 204 ? -26.616 -4.752  -18.998 1.00 34.54  ? 213 LEU A CD2   1 
ATOM   1534 N  N     . GLY A 1 205 ? -28.868 -9.550  -19.201 1.00 38.82  ? 214 GLY A N     1 
ATOM   1535 C  CA    . GLY A 1 205 ? -29.169 -10.961 -19.537 1.00 40.19  ? 214 GLY A CA    1 
ATOM   1536 C  C     . GLY A 1 205 ? -29.400 -11.888 -18.339 1.00 41.08  ? 214 GLY A C     1 
ATOM   1537 O  O     . GLY A 1 205 ? -28.999 -13.065 -18.445 1.00 41.42  ? 214 GLY A O     1 
ATOM   1538 N  N     . THR A 1 206 ? -30.122 -11.483 -17.291 1.00 41.59  ? 215 THR A N     1 
ATOM   1539 C  CA    . THR A 1 206 ? -30.634 -12.449 -16.291 1.00 40.83  ? 215 THR A CA    1 
ATOM   1540 C  C     . THR A 1 206 ? -32.116 -12.198 -16.017 1.00 42.30  ? 215 THR A C     1 
ATOM   1541 O  O     . THR A 1 206 ? -32.504 -11.031 -15.996 1.00 41.33  ? 215 THR A O     1 
ATOM   1542 C  CB    . THR A 1 206 ? -29.784 -12.443 -15.026 1.00 41.40  ? 215 THR A CB    1 
ATOM   1543 O  OG1   . THR A 1 206 ? -30.496 -13.191 -14.041 1.00 47.66  ? 215 THR A OG1   1 
ATOM   1544 C  CG2   . THR A 1 206 ? -29.516 -11.060 -14.493 1.00 41.91  ? 215 THR A CG2   1 
ATOM   1545 N  N     . SER A 1 207 ? -32.887 -13.274 -15.800 1.00 37.76  ? 216 SER A N     1 
ATOM   1546 C  CA    . SER A 1 207 ? -34.342 -13.230 -15.545 1.00 39.93  ? 216 SER A CA    1 
ATOM   1547 C  C     . SER A 1 207 ? -34.590 -13.185 -14.037 1.00 41.47  ? 216 SER A C     1 
ATOM   1548 O  O     . SER A 1 207 ? -35.749 -13.062 -13.641 1.00 37.91  ? 216 SER A O     1 
ATOM   1549 C  CB    . SER A 1 207 ? -35.009 -14.401 -16.186 1.00 39.74  ? 216 SER A CB    1 
ATOM   1550 O  OG    . SER A 1 207 ? -34.454 -15.617 -15.710 1.00 39.03  ? 216 SER A OG    1 
ATOM   1551 N  N     . LEU A 1 208 ? -33.521 -13.304 -13.242 1.00 42.56  ? 217 LEU A N     1 
ATOM   1552 C  CA    . LEU A 1 208 ? -33.501 -13.048 -11.769 1.00 44.23  ? 217 LEU A CA    1 
ATOM   1553 C  C     . LEU A 1 208 ? -34.388 -14.003 -10.959 1.00 40.19  ? 217 LEU A C     1 
ATOM   1554 O  O     . LEU A 1 208 ? -34.795 -13.639 -9.859  1.00 45.49  ? 217 LEU A O     1 
ATOM   1555 C  CB    . LEU A 1 208 ? -33.923 -11.597 -11.535 1.00 42.07  ? 217 LEU A CB    1 
ATOM   1556 C  CG    . LEU A 1 208 ? -32.937 -10.599 -12.117 1.00 42.47  ? 217 LEU A CG    1 
ATOM   1557 C  CD1   . LEU A 1 208 ? -33.534 -9.206  -12.160 1.00 45.23  ? 217 LEU A CD1   1 
ATOM   1558 C  CD2   . LEU A 1 208 ? -31.655 -10.629 -11.307 1.00 42.03  ? 217 LEU A CD2   1 
ATOM   1559 N  N     . GLN A 1 209 ? -34.547 -15.227 -11.408 1.00 45.48  ? 218 GLN A N     1 
ATOM   1560 C  CA    . GLN A 1 209 ? -35.426 -16.190 -10.717 1.00 41.59  ? 218 GLN A CA    1 
ATOM   1561 C  C     . GLN A 1 209 ? -34.680 -16.968 -9.638  1.00 39.60  ? 218 GLN A C     1 
ATOM   1562 O  O     . GLN A 1 209 ? -35.349 -17.483 -8.796  1.00 48.29  ? 218 GLN A O     1 
ATOM   1563 C  CB    . GLN A 1 209 ? -36.054 -17.105 -11.760 1.00 43.64  ? 218 GLN A CB    1 
ATOM   1564 C  CG    . GLN A 1 209 ? -36.784 -16.352 -12.855 1.00 38.07  ? 218 GLN A CG    1 
ATOM   1565 C  CD    . GLN A 1 209 ? -37.543 -17.305 -13.740 1.00 45.42  ? 218 GLN A CD    1 
ATOM   1566 O  OE1   . GLN A 1 209 ? -38.372 -18.064 -13.280 1.00 52.75  ? 218 GLN A OE1   1 
ATOM   1567 N  NE2   . GLN A 1 209 ? -37.255 -17.295 -15.027 1.00 47.99  ? 218 GLN A NE2   1 
ATOM   1568 N  N     . ILE A 1 210 ? -33.359 -17.064 -9.662  1.00 44.38  ? 219 ILE A N     1 
ATOM   1569 C  CA    . ILE A 1 210 ? -32.633 -17.911 -8.683  1.00 45.33  ? 219 ILE A CA    1 
ATOM   1570 C  C     . ILE A 1 210 ? -32.549 -17.182 -7.351  1.00 44.55  ? 219 ILE A C     1 
ATOM   1571 O  O     . ILE A 1 210 ? -32.193 -16.050 -7.347  1.00 47.20  ? 219 ILE A O     1 
ATOM   1572 C  CB    . ILE A 1 210 ? -31.281 -18.381 -9.235  1.00 50.35  ? 219 ILE A CB    1 
ATOM   1573 C  CG1   . ILE A 1 210 ? -31.540 -19.237 -10.461 1.00 58.17  ? 219 ILE A CG1   1 
ATOM   1574 C  CG2   . ILE A 1 210 ? -30.517 -19.167 -8.181  1.00 50.06  ? 219 ILE A CG2   1 
ATOM   1575 C  CD1   . ILE A 1 210 ? -32.143 -20.587 -10.093 1.00 56.20  ? 219 ILE A CD1   1 
ATOM   1576 N  N     . ARG A 1 211 ? -32.799 -17.888 -6.265  1.00 55.83  ? 220 ARG A N     1 
ATOM   1577 C  CA    . ARG A 1 211 ? -33.155 -17.222 -5.007  1.00 64.06  ? 220 ARG A CA    1 
ATOM   1578 C  C     . ARG A 1 211 ? -32.075 -16.326 -4.447  1.00 76.16  ? 220 ARG A C     1 
ATOM   1579 O  O     . ARG A 1 211 ? -32.483 -15.260 -4.131  1.00 111.59 ? 220 ARG A O     1 
ATOM   1580 C  CB    . ARG A 1 211 ? -33.612 -18.123 -3.870  1.00 77.25  ? 220 ARG A CB    1 
ATOM   1581 C  CG    . ARG A 1 211 ? -33.645 -17.361 -2.550  1.00 78.88  ? 220 ARG A CG    1 
ATOM   1582 C  CD    . ARG A 1 211 ? -34.902 -17.554 -1.762  1.00 90.26  ? 220 ARG A CD    1 
ATOM   1583 N  NE    . ARG A 1 211 ? -34.604 -17.765 -0.355  1.00 91.13  ? 220 ARG A NE    1 
ATOM   1584 C  CZ    . ARG A 1 211 ? -35.406 -18.392 0.495   1.00 90.28  ? 220 ARG A CZ    1 
ATOM   1585 N  NH1   . ARG A 1 211 ? -36.573 -18.871 0.095   1.00 91.71  ? 220 ARG A NH1   1 
ATOM   1586 N  NH2   . ARG A 1 211 ? -35.038 -18.540 1.751   1.00 87.52  ? 220 ARG A NH2   1 
ATOM   1587 N  N     . PRO A 1 212 ? -30.822 -16.646 -4.106  1.00 60.39  ? 221 PRO A N     1 
ATOM   1588 C  CA    . PRO A 1 212 ? -29.974 -15.587 -3.550  1.00 51.19  ? 221 PRO A CA    1 
ATOM   1589 C  C     . PRO A 1 212 ? -29.499 -14.633 -4.664  1.00 49.66  ? 221 PRO A C     1 
ATOM   1590 O  O     . PRO A 1 212 ? -29.670 -13.490 -4.548  1.00 44.52  ? 221 PRO A O     1 
ATOM   1591 C  CB    . PRO A 1 212 ? -28.861 -16.337 -2.824  1.00 47.16  ? 221 PRO A CB    1 
ATOM   1592 C  CG    . PRO A 1 212 ? -28.893 -17.727 -3.419  1.00 50.78  ? 221 PRO A CG    1 
ATOM   1593 C  CD    . PRO A 1 212 ? -30.240 -17.972 -4.098  1.00 53.27  ? 221 PRO A CD    1 
ATOM   1594 N  N     . SER A 1 213 ? -29.033 -15.180 -5.769  1.00 44.14  ? 222 SER A N     1 
ATOM   1595 C  CA    . SER A 1 213 ? -28.399 -14.436 -6.889  1.00 46.61  ? 222 SER A CA    1 
ATOM   1596 C  C     . SER A 1 213 ? -29.300 -13.355 -7.472  1.00 41.74  ? 222 SER A C     1 
ATOM   1597 O  O     . SER A 1 213 ? -28.833 -12.257 -7.640  1.00 42.01  ? 222 SER A O     1 
ATOM   1598 C  CB    . SER A 1 213 ? -28.040 -15.375 -7.964  1.00 43.83  ? 222 SER A CB    1 
ATOM   1599 O  OG    . SER A 1 213 ? -27.721 -16.652 -7.441  1.00 55.78  ? 222 SER A OG    1 
ATOM   1600 N  N     . GLY A 1 214 ? -30.556 -13.690 -7.761  1.00 41.51  ? 223 GLY A N     1 
ATOM   1601 C  CA    . GLY A 1 214 ? -31.507 -12.774 -8.402  1.00 38.29  ? 223 GLY A CA    1 
ATOM   1602 C  C     . GLY A 1 214 ? -31.982 -11.672 -7.498  1.00 41.29  ? 223 GLY A C     1 
ATOM   1603 O  O     . GLY A 1 214 ? -32.517 -10.723 -8.012  1.00 42.55  ? 223 GLY A O     1 
ATOM   1604 N  N     . ASN A 1 215 ? -31.853 -11.817 -6.188  1.00 42.37  ? 224 ASN A N     1 
ATOM   1605 C  CA    . ASN A 1 215 ? -32.353 -10.780 -5.269  1.00 48.10  ? 224 ASN A CA    1 
ATOM   1606 C  C     . ASN A 1 215 ? -31.341 -9.676  -5.034  1.00 42.43  ? 224 ASN A C     1 
ATOM   1607 O  O     . ASN A 1 215 ? -31.767 -8.661  -4.605  1.00 47.62  ? 224 ASN A O     1 
ATOM   1608 C  CB    . ASN A 1 215 ? -32.553 -11.292 -3.859  1.00 52.90  ? 224 ASN A CB    1 
ATOM   1609 C  CG    . ASN A 1 215 ? -33.628 -12.348 -3.731  1.00 57.57  ? 224 ASN A CG    1 
ATOM   1610 O  OD1   . ASN A 1 215 ? -34.451 -12.542 -4.616  1.00 56.24  ? 224 ASN A OD1   1 
ATOM   1611 N  ND2   . ASN A 1 215 ? -33.587 -13.085 -2.636  1.00 62.81  ? 224 ASN A ND2   1 
ATOM   1612 N  N     . LEU A 1 216 ? -30.061 -9.902  -5.286  1.00 44.79  ? 225 LEU A N     1 
ATOM   1613 C  CA    . LEU A 1 216 ? -28.980 -8.987  -4.862  1.00 48.24  ? 225 LEU A CA    1 
ATOM   1614 C  C     . LEU A 1 216 ? -29.166 -7.589  -5.455  1.00 45.64  ? 225 LEU A C     1 
ATOM   1615 O  O     . LEU A 1 216 ? -28.892 -6.598  -4.809  1.00 42.06  ? 225 LEU A O     1 
ATOM   1616 C  CB    . LEU A 1 216 ? -27.636 -9.618  -5.238  1.00 50.58  ? 225 LEU A CB    1 
ATOM   1617 C  CG    . LEU A 1 216 ? -27.218 -10.774 -4.330  1.00 49.95  ? 225 LEU A CG    1 
ATOM   1618 C  CD1   . LEU A 1 216 ? -26.221 -11.692 -5.021  1.00 44.57  ? 225 LEU A CD1   1 
ATOM   1619 C  CD2   . LEU A 1 216 ? -26.631 -10.234 -3.023  1.00 55.47  ? 225 LEU A CD2   1 
ATOM   1620 N  N     . PRO A 1 217 ? -29.585 -7.405  -6.711  1.00 39.32  ? 226 PRO A N     1 
ATOM   1621 C  CA    . PRO A 1 217 ? -29.849 -6.055  -7.174  1.00 46.23  ? 226 PRO A CA    1 
ATOM   1622 C  C     . PRO A 1 217 ? -30.908 -5.289  -6.361  1.00 46.59  ? 226 PRO A C     1 
ATOM   1623 O  O     . PRO A 1 217 ? -30.823 -4.090  -6.372  1.00 51.77  ? 226 PRO A O     1 
ATOM   1624 C  CB    . PRO A 1 217 ? -30.280 -6.293  -8.621  1.00 47.29  ? 226 PRO A CB    1 
ATOM   1625 C  CG    . PRO A 1 217 ? -29.564 -7.569  -8.977  1.00 42.93  ? 226 PRO A CG    1 
ATOM   1626 C  CD    . PRO A 1 217 ? -29.736 -8.414  -7.752  1.00 41.15  ? 226 PRO A CD    1 
ATOM   1627 N  N     . LEU A 1 218 ? -31.872 -5.956  -5.715  1.00 49.51  ? 227 LEU A N     1 
ATOM   1628 C  CA    . LEU A 1 218 ? -32.905 -5.299  -4.857  1.00 50.51  ? 227 LEU A CA    1 
ATOM   1629 C  C     . LEU A 1 218 ? -32.194 -4.671  -3.656  1.00 53.75  ? 227 LEU A C     1 
ATOM   1630 O  O     . LEU A 1 218 ? -32.607 -3.585  -3.250  1.00 55.59  ? 227 LEU A O     1 
ATOM   1631 C  CB    . LEU A 1 218 ? -33.965 -6.289  -4.354  1.00 55.62  ? 227 LEU A CB    1 
ATOM   1632 C  CG    . LEU A 1 218 ? -34.885 -6.941  -5.394  1.00 53.85  ? 227 LEU A CG    1 
ATOM   1633 C  CD1   . LEU A 1 218 ? -36.123 -7.478  -4.692  1.00 50.34  ? 227 LEU A CD1   1 
ATOM   1634 C  CD2   . LEU A 1 218 ? -35.252 -5.986  -6.510  1.00 54.14  ? 227 LEU A CD2   1 
ATOM   1635 N  N     . ALA A 1 219 ? -31.160 -5.311  -3.110  1.00 45.84  ? 228 ALA A N     1 
ATOM   1636 C  CA    . ALA A 1 219 ? -30.388 -4.751  -1.971  1.00 51.66  ? 228 ALA A CA    1 
ATOM   1637 C  C     . ALA A 1 219 ? -29.847 -3.350  -2.312  1.00 54.35  ? 228 ALA A C     1 
ATOM   1638 O  O     . ALA A 1 219 ? -29.698 -2.506  -1.364  1.00 47.01  ? 228 ALA A O     1 
ATOM   1639 C  CB    . ALA A 1 219 ? -29.265 -5.673  -1.550  1.00 49.84  ? 228 ALA A CB    1 
ATOM   1640 N  N     . THR A 1 220 ? -29.534 -3.091  -3.583  1.00 44.76  ? 229 THR A N     1 
ATOM   1641 C  CA    . THR A 1 220 ? -29.194 -1.721  -4.053  1.00 48.41  ? 229 THR A CA    1 
ATOM   1642 C  C     . THR A 1 220 ? -30.413 -0.803  -3.819  1.00 44.83  ? 229 THR A C     1 
ATOM   1643 O  O     . THR A 1 220 ? -30.204 0.322   -3.420  1.00 44.54  ? 229 THR A O     1 
ATOM   1644 C  CB    . THR A 1 220 ? -28.669 -1.737  -5.503  1.00 47.23  ? 229 THR A CB    1 
ATOM   1645 O  OG1   . THR A 1 220 ? -27.653 -2.739  -5.632  1.00 37.99  ? 229 THR A OG1   1 
ATOM   1646 C  CG2   . THR A 1 220 ? -28.117 -0.391  -5.932  1.00 48.31  ? 229 THR A CG2   1 
ATOM   1647 N  N     . LYS A 1 221 ? -31.659 -1.253  -4.041  1.00 53.95  ? 230 LYS A N     1 
ATOM   1648 C  CA    . LYS A 1 221 ? -32.831 -0.323  -3.978  1.00 59.95  ? 230 LYS A CA    1 
ATOM   1649 C  C     . LYS A 1 221 ? -33.113 0.150   -2.537  1.00 66.02  ? 230 LYS A C     1 
ATOM   1650 O  O     . LYS A 1 221 ? -33.565 1.290   -2.395  1.00 82.03  ? 230 LYS A O     1 
ATOM   1651 C  CB    . LYS A 1 221 ? -34.056 -0.892  -4.698  1.00 57.91  ? 230 LYS A CB    1 
ATOM   1652 C  CG    . LYS A 1 221 ? -34.166 -0.428  -6.146  1.00 60.59  ? 230 LYS A CG    1 
ATOM   1653 C  CD    . LYS A 1 221 ? -35.572 -0.288  -6.692  1.00 59.28  ? 230 LYS A CD    1 
ATOM   1654 C  CE    . LYS A 1 221 ? -36.413 0.829   -6.104  1.00 60.44  ? 230 LYS A CE    1 
ATOM   1655 N  NZ    . LYS A 1 221 ? -36.093 2.149   -6.697  1.00 61.36  ? 230 LYS A NZ    1 
ATOM   1656 N  N     . ARG A 1 222 ? -32.788 -0.617  -1.501  1.00 71.68  ? 231 ARG A N     1 
ATOM   1657 C  CA    . ARG A 1 222 ? -32.822 -0.097  -0.105  1.00 81.70  ? 231 ARG A CA    1 
ATOM   1658 C  C     . ARG A 1 222 ? -31.831 1.072   0.016   1.00 77.48  ? 231 ARG A C     1 
ATOM   1659 O  O     . ARG A 1 222 ? -30.717 0.959   -0.500  1.00 83.59  ? 231 ARG A O     1 
ATOM   1660 C  CB    . ARG A 1 222 ? -32.484 -1.182  0.923   1.00 88.90  ? 231 ARG A CB    1 
ATOM   1661 C  CG    . ARG A 1 222 ? -30.996 -1.303  1.237   1.00 93.43  ? 231 ARG A CG    1 
ATOM   1662 C  CD    . ARG A 1 222 ? -30.645 -2.411  2.223   1.00 100.74 ? 231 ARG A CD    1 
ATOM   1663 N  NE    . ARG A 1 222 ? -30.742 -3.760  1.671   1.00 92.26  ? 231 ARG A NE    1 
ATOM   1664 C  CZ    . ARG A 1 222 ? -31.069 -4.856  2.358   1.00 79.93  ? 231 ARG A CZ    1 
ATOM   1665 N  NH1   . ARG A 1 222 ? -31.347 -4.796  3.651   1.00 79.66  ? 231 ARG A NH1   1 
ATOM   1666 N  NH2   . ARG A 1 222 ? -31.141 -6.013  1.728   1.00 83.15  ? 231 ARG A NH2   1 
ATOM   1667 N  N     . ARG A 1 223 ? -32.243 2.132   0.713   1.00 78.84  ? 232 ARG A N     1 
ATOM   1668 C  CA    . ARG A 1 223 ? -31.488 3.388   0.999   1.00 77.27  ? 232 ARG A CA    1 
ATOM   1669 C  C     . ARG A 1 223 ? -31.177 4.154   -0.293  1.00 63.08  ? 232 ARG A C     1 
ATOM   1670 O  O     . ARG A 1 223 ? -30.076 4.678   -0.407  1.00 65.27  ? 232 ARG A O     1 
ATOM   1671 C  CB    . ARG A 1 223 ? -30.242 3.110   1.852   1.00 85.35  ? 232 ARG A CB    1 
ATOM   1672 C  CG    . ARG A 1 223 ? -30.500 3.152   3.356   1.00 82.53  ? 232 ARG A CG    1 
ATOM   1673 C  CD    . ARG A 1 223 ? -29.237 3.134   4.200   1.00 88.10  ? 232 ARG A CD    1 
ATOM   1674 N  NE    . ARG A 1 223 ? -28.222 2.251   3.618   1.00 93.49  ? 232 ARG A NE    1 
ATOM   1675 C  CZ    . ARG A 1 223 ? -27.020 2.623   3.157   1.00 91.58  ? 232 ARG A CZ    1 
ATOM   1676 N  NH1   . ARG A 1 223 ? -26.209 1.712   2.644   1.00 92.49  ? 232 ARG A NH1   1 
ATOM   1677 N  NH2   . ARG A 1 223 ? -26.615 3.884   3.213   1.00 95.03  ? 232 ARG A NH2   1 
ATOM   1678 N  N     . GLY A 1 224 ? -32.147 4.259   -1.204  1.00 64.98  ? 233 GLY A N     1 
ATOM   1679 C  CA    . GLY A 1 224 ? -32.172 5.269   -2.286  1.00 60.42  ? 233 GLY A CA    1 
ATOM   1680 C  C     . GLY A 1 224 ? -31.597 4.810   -3.623  1.00 51.39  ? 233 GLY A C     1 
ATOM   1681 O  O     . GLY A 1 224 ? -31.733 5.562   -4.601  1.00 48.89  ? 233 GLY A O     1 
ATOM   1682 N  N     . GLY A 1 225 ? -30.986 3.631   -3.684  1.00 48.11  ? 234 GLY A N     1 
ATOM   1683 C  CA    . GLY A 1 225 ? -30.220 3.168   -4.855  1.00 51.12  ? 234 GLY A CA    1 
ATOM   1684 C  C     . GLY A 1 225 ? -31.131 2.956   -6.045  1.00 42.69  ? 234 GLY A C     1 
ATOM   1685 O  O     . GLY A 1 225 ? -32.289 2.652   -5.831  1.00 56.07  ? 234 GLY A O     1 
ATOM   1686 N  N     . ARG A 1 226 ? -30.620 3.131   -7.258  1.00 49.41  ? 235 ARG A N     1 
ATOM   1687 C  CA    . ARG A 1 226 ? -31.388 2.974   -8.518  1.00 47.32  ? 235 ARG A CA    1 
ATOM   1688 C  C     . ARG A 1 226 ? -31.104 1.569   -9.055  1.00 44.90  ? 235 ARG A C     1 
ATOM   1689 O  O     . ARG A 1 226 ? -29.972 1.083   -8.877  1.00 41.20  ? 235 ARG A O     1 
ATOM   1690 C  CB    . ARG A 1 226 ? -31.000 4.067   -9.513  1.00 50.71  ? 235 ARG A CB    1 
ATOM   1691 C  CG    . ARG A 1 226 ? -31.133 5.487   -8.988  1.00 57.56  ? 235 ARG A CG    1 
ATOM   1692 C  CD    . ARG A 1 226 ? -32.561 5.963   -8.914  1.00 69.28  ? 235 ARG A CD    1 
ATOM   1693 N  NE    . ARG A 1 226 ? -32.647 7.286   -8.313  1.00 78.96  ? 235 ARG A NE    1 
ATOM   1694 C  CZ    . ARG A 1 226 ? -32.631 8.449   -8.971  1.00 79.72  ? 235 ARG A CZ    1 
ATOM   1695 N  NH1   . ARG A 1 226 ? -32.543 8.490   -10.292 1.00 70.91  ? 235 ARG A NH1   1 
ATOM   1696 N  NH2   . ARG A 1 226 ? -32.710 9.579   -8.288  1.00 80.55  ? 235 ARG A NH2   1 
ATOM   1697 N  N     . LEU A 1 227 ? -32.096 0.918   -9.660  1.00 43.86  ? 236 LEU A N     1 
ATOM   1698 C  CA    . LEU A 1 227 ? -31.908 -0.412  -10.293 1.00 41.96  ? 236 LEU A CA    1 
ATOM   1699 C  C     . LEU A 1 227 ? -32.305 -0.332  -11.771 1.00 42.16  ? 236 LEU A C     1 
ATOM   1700 O  O     . LEU A 1 227 ? -33.421 0.156   -12.059 1.00 38.14  ? 236 LEU A O     1 
ATOM   1701 C  CB    . LEU A 1 227 ? -32.767 -1.429  -9.560  1.00 43.04  ? 236 LEU A CB    1 
ATOM   1702 C  CG    . LEU A 1 227 ? -33.049 -2.715  -10.318 1.00 43.56  ? 236 LEU A CG    1 
ATOM   1703 C  CD1   . LEU A 1 227 ? -31.804 -3.593  -10.321 1.00 49.45  ? 236 LEU A CD1   1 
ATOM   1704 C  CD2   . LEU A 1 227 ? -34.229 -3.425  -9.698  1.00 39.21  ? 236 LEU A CD2   1 
ATOM   1705 N  N     . VAL A 1 228 ? -31.444 -0.848  -12.652 1.00 41.42  ? 237 VAL A N     1 
ATOM   1706 C  CA    . VAL A 1 228 ? -31.704 -0.927  -14.124 1.00 46.00  ? 237 VAL A CA    1 
ATOM   1707 C  C     . VAL A 1 228 ? -31.686 -2.377  -14.575 1.00 43.83  ? 237 VAL A C     1 
ATOM   1708 O  O     . VAL A 1 228 ? -30.722 -3.094  -14.264 1.00 45.31  ? 237 VAL A O     1 
ATOM   1709 C  CB    . VAL A 1 228 ? -30.685 -0.137  -14.955 1.00 45.97  ? 237 VAL A CB    1 
ATOM   1710 C  CG1   . VAL A 1 228 ? -30.972 -0.280  -16.444 1.00 47.59  ? 237 VAL A CG1   1 
ATOM   1711 C  CG2   . VAL A 1 228 ? -30.695 1.317   -14.552 1.00 52.38  ? 237 VAL A CG2   1 
ATOM   1712 N  N     . ILE A 1 229 ? -32.692 -2.759  -15.341 1.00 46.68  ? 238 ILE A N     1 
ATOM   1713 C  CA    . ILE A 1 229 ? -32.815 -4.143  -15.859 1.00 47.44  ? 238 ILE A CA    1 
ATOM   1714 C  C     . ILE A 1 229 ? -32.778 -4.096  -17.380 1.00 46.58  ? 238 ILE A C     1 
ATOM   1715 O  O     . ILE A 1 229 ? -33.681 -3.505  -17.953 1.00 46.29  ? 238 ILE A O     1 
ATOM   1716 C  CB    . ILE A 1 229 ? -34.084 -4.795  -15.307 1.00 44.43  ? 238 ILE A CB    1 
ATOM   1717 C  CG1   . ILE A 1 229 ? -33.959 -4.940  -13.788 1.00 50.00  ? 238 ILE A CG1   1 
ATOM   1718 C  CG2   . ILE A 1 229 ? -34.365 -6.110  -16.025 1.00 40.84  ? 238 ILE A CG2   1 
ATOM   1719 C  CD1   . ILE A 1 229 ? -34.841 -6.019  -13.163 1.00 49.33  ? 238 ILE A CD1   1 
ATOM   1720 N  N     . VAL A 1 230 ? -31.743 -4.684  -17.990 1.00 44.55  ? 239 VAL A N     1 
ATOM   1721 C  CA    . VAL A 1 230 ? -31.664 -4.842  -19.472 1.00 41.01  ? 239 VAL A CA    1 
ATOM   1722 C  C     . VAL A 1 230 ? -31.862 -6.327  -19.772 1.00 40.61  ? 239 VAL A C     1 
ATOM   1723 O  O     . VAL A 1 230 ? -31.084 -7.103  -19.240 1.00 41.04  ? 239 VAL A O     1 
ATOM   1724 C  CB    . VAL A 1 230 ? -30.336 -4.274  -19.986 1.00 39.10  ? 239 VAL A CB    1 
ATOM   1725 C  CG1   . VAL A 1 230 ? -30.291 -4.215  -21.498 1.00 40.51  ? 239 VAL A CG1   1 
ATOM   1726 C  CG2   . VAL A 1 230 ? -30.100 -2.892  -19.395 1.00 39.95  ? 239 VAL A CG2   1 
ATOM   1727 N  N     . ASN A 1 231 ? -32.920 -6.692  -20.517 1.00 41.60  ? 240 ASN A N     1 
ATOM   1728 C  CA    . ASN A 1 231 ? -33.396 -8.093  -20.741 1.00 43.20  ? 240 ASN A CA    1 
ATOM   1729 C  C     . ASN A 1 231 ? -34.465 -8.111  -21.839 1.00 42.62  ? 240 ASN A C     1 
ATOM   1730 O  O     . ASN A 1 231 ? -35.339 -7.242  -21.799 1.00 47.10  ? 240 ASN A O     1 
ATOM   1731 C  CB    . ASN A 1 231 ? -34.012 -8.748  -19.494 1.00 40.94  ? 240 ASN A CB    1 
ATOM   1732 C  CG    . ASN A 1 231 ? -33.743 -10.245 -19.404 1.00 45.08  ? 240 ASN A CG    1 
ATOM   1733 O  OD1   . ASN A 1 231 ? -32.587 -10.691 -19.452 1.00 41.26  ? 240 ASN A OD1   1 
ATOM   1734 N  ND2   . ASN A 1 231 ? -34.791 -11.044 -19.234 1.00 41.34  ? 240 ASN A ND2   1 
ATOM   1735 N  N     . LEU A 1 232 ? -34.422 -9.094  -22.743 1.00 41.21  ? 241 LEU A N     1 
ATOM   1736 C  CA    . LEU A 1 232 ? -35.421 -9.277  -23.834 1.00 45.09  ? 241 LEU A CA    1 
ATOM   1737 C  C     . LEU A 1 232 ? -36.779 -9.805  -23.314 1.00 47.43  ? 241 LEU A C     1 
ATOM   1738 O  O     . LEU A 1 232 ? -37.802 -9.521  -23.956 1.00 53.42  ? 241 LEU A O     1 
ATOM   1739 C  CB    . LEU A 1 232 ? -34.835 -10.248 -24.860 1.00 48.29  ? 241 LEU A CB    1 
ATOM   1740 C  CG    . LEU A 1 232 ? -33.891 -9.646  -25.883 1.00 49.98  ? 241 LEU A CG    1 
ATOM   1741 C  CD1   . LEU A 1 232 ? -33.410 -10.712 -26.844 1.00 50.21  ? 241 LEU A CD1   1 
ATOM   1742 C  CD2   . LEU A 1 232 ? -34.567 -8.505  -26.635 1.00 50.61  ? 241 LEU A CD2   1 
ATOM   1743 N  N     . GLN A 1 233 ? -36.777 -10.612 -22.254 1.00 42.05  ? 242 GLN A N     1 
ATOM   1744 C  CA    . GLN A 1 233 ? -37.973 -11.174 -21.582 1.00 42.31  ? 242 GLN A CA    1 
ATOM   1745 C  C     . GLN A 1 233 ? -38.258 -10.439 -20.265 1.00 45.70  ? 242 GLN A C     1 
ATOM   1746 O  O     . GLN A 1 233 ? -37.364 -9.875  -19.640 1.00 43.10  ? 242 GLN A O     1 
ATOM   1747 C  CB    . GLN A 1 233 ? -37.710 -12.628 -21.208 1.00 40.98  ? 242 GLN A CB    1 
ATOM   1748 C  CG    . GLN A 1 233 ? -37.697 -13.611 -22.363 1.00 42.73  ? 242 GLN A CG    1 
ATOM   1749 C  CD    . GLN A 1 233 ? -37.437 -14.995 -21.813 1.00 49.01  ? 242 GLN A CD    1 
ATOM   1750 O  OE1   . GLN A 1 233 ? -36.521 -15.188 -21.016 1.00 45.77  ? 242 GLN A OE1   1 
ATOM   1751 N  NE2   . GLN A 1 233 ? -38.253 -15.967 -22.207 1.00 52.28  ? 242 GLN A NE2   1 
ATOM   1752 N  N     . PRO A 1 234 ? -39.511 -10.465 -19.760 1.00 47.76  ? 243 PRO A N     1 
ATOM   1753 C  CA    . PRO A 1 234 ? -39.783 -10.077 -18.380 1.00 47.42  ? 243 PRO A CA    1 
ATOM   1754 C  C     . PRO A 1 234 ? -38.809 -10.821 -17.465 1.00 45.82  ? 243 PRO A C     1 
ATOM   1755 O  O     . PRO A 1 234 ? -38.301 -11.801 -17.902 1.00 45.46  ? 243 PRO A O     1 
ATOM   1756 C  CB    . PRO A 1 234 ? -41.215 -10.561 -18.074 1.00 46.04  ? 243 PRO A CB    1 
ATOM   1757 C  CG    . PRO A 1 234 ? -41.857 -10.752 -19.451 1.00 52.69  ? 243 PRO A CG    1 
ATOM   1758 C  CD    . PRO A 1 234 ? -40.733 -10.865 -20.478 1.00 52.22  ? 243 PRO A CD    1 
ATOM   1759 N  N     . THR A 1 235 ? -38.634 -10.315 -16.246 1.00 44.05  ? 244 THR A N     1 
ATOM   1760 C  CA    . THR A 1 235 ? -37.757 -10.800 -15.159 1.00 42.37  ? 244 THR A CA    1 
ATOM   1761 C  C     . THR A 1 235 ? -38.534 -10.746 -13.849 1.00 41.80  ? 244 THR A C     1 
ATOM   1762 O  O     . THR A 1 235 ? -39.589 -10.041 -13.784 1.00 38.95  ? 244 THR A O     1 
ATOM   1763 C  CB    . THR A 1 235 ? -36.500 -9.931  -15.012 1.00 47.91  ? 244 THR A CB    1 
ATOM   1764 O  OG1   . THR A 1 235 ? -36.739 -8.929  -14.020 1.00 40.23  ? 244 THR A OG1   1 
ATOM   1765 C  CG2   . THR A 1 235 ? -36.056 -9.300  -16.321 1.00 42.97  ? 244 THR A CG2   1 
ATOM   1766 N  N     . LYS A 1 236 ? -38.012 -11.408 -12.820 1.00 45.21  ? 245 LYS A N     1 
ATOM   1767 C  CA    . LYS A 1 236 ? -38.755 -11.610 -11.542 1.00 49.17  ? 245 LYS A CA    1 
ATOM   1768 C  C     . LYS A 1 236 ? -39.085 -10.252 -10.926 1.00 41.14  ? 245 LYS A C     1 
ATOM   1769 O  O     . LYS A 1 236 ? -40.077 -10.161 -10.304 1.00 47.17  ? 245 LYS A O     1 
ATOM   1770 C  CB    . LYS A 1 236 ? -37.956 -12.503 -10.582 1.00 55.25  ? 245 LYS A CB    1 
ATOM   1771 C  CG    . LYS A 1 236 ? -38.662 -12.922 -9.292  1.00 59.69  ? 245 LYS A CG    1 
ATOM   1772 C  CD    . LYS A 1 236 ? -37.942 -14.083 -8.612  1.00 65.79  ? 245 LYS A CD    1 
ATOM   1773 C  CE    . LYS A 1 236 ? -38.690 -14.751 -7.473  1.00 64.98  ? 245 LYS A CE    1 
ATOM   1774 N  NZ    . LYS A 1 236 ? -38.509 -16.227 -7.526  1.00 66.31  ? 245 LYS A NZ    1 
ATOM   1775 N  N     . HIS A 1 237 ? -38.237 -9.248  -11.087 1.00 45.70  ? 246 HIS A N     1 
ATOM   1776 C  CA    . HIS A 1 237 ? -38.268 -8.015  -10.282 1.00 46.32  ? 246 HIS A CA    1 
ATOM   1777 C  C     . HIS A 1 237 ? -38.556 -6.796  -11.149 1.00 44.57  ? 246 HIS A C     1 
ATOM   1778 O  O     . HIS A 1 237 ? -38.352 -5.716  -10.658 1.00 54.26  ? 246 HIS A O     1 
ATOM   1779 C  CB    . HIS A 1 237 ? -36.956 -7.914  -9.496  1.00 53.60  ? 246 HIS A CB    1 
ATOM   1780 C  CG    . HIS A 1 237 ? -36.870 -8.903  -8.365  1.00 55.46  ? 246 HIS A CG    1 
ATOM   1781 N  ND1   . HIS A 1 237 ? -35.799 -9.765  -8.203  1.00 50.17  ? 246 HIS A ND1   1 
ATOM   1782 C  CD2   . HIS A 1 237 ? -37.732 -9.184  -7.363  1.00 54.56  ? 246 HIS A CD2   1 
ATOM   1783 C  CE1   . HIS A 1 237 ? -35.992 -10.492 -7.121  1.00 60.24  ? 246 HIS A CE1   1 
ATOM   1784 N  NE2   . HIS A 1 237 ? -37.171 -10.152 -6.588  1.00 58.82  ? 246 HIS A NE2   1 
ATOM   1785 N  N     . ASP A 1 238 ? -39.034 -6.966  -12.377 1.00 46.89  ? 247 ASP A N     1 
ATOM   1786 C  CA    . ASP A 1 238 ? -39.332 -5.847  -13.316 1.00 46.40  ? 247 ASP A CA    1 
ATOM   1787 C  C     . ASP A 1 238 ? -39.977 -4.659  -12.596 1.00 50.39  ? 247 ASP A C     1 
ATOM   1788 O  O     . ASP A 1 238 ? -39.697 -3.514  -13.006 1.00 63.02  ? 247 ASP A O     1 
ATOM   1789 C  CB    . ASP A 1 238 ? -40.256 -6.299  -14.444 1.00 45.93  ? 247 ASP A CB    1 
ATOM   1790 C  CG    . ASP A 1 238 ? -39.582 -6.985  -15.621 1.00 44.92  ? 247 ASP A CG    1 
ATOM   1791 O  OD1   . ASP A 1 238 ? -38.352 -6.889  -15.758 1.00 52.11  ? 247 ASP A OD1   1 
ATOM   1792 O  OD2   . ASP A 1 238 ? -40.304 -7.633  -16.391 1.00 44.82  ? 247 ASP A OD2   1 
ATOM   1793 N  N     . ARG A 1 239 ? -40.835 -4.904  -11.600 1.00 56.22  ? 248 ARG A N     1 
ATOM   1794 C  CA    . ARG A 1 239 ? -41.618 -3.858  -10.869 1.00 57.80  ? 248 ARG A CA    1 
ATOM   1795 C  C     . ARG A 1 239 ? -40.703 -2.994  -9.969  1.00 58.27  ? 248 ARG A C     1 
ATOM   1796 O  O     . ARG A 1 239 ? -41.067 -1.864  -9.619  1.00 54.26  ? 248 ARG A O     1 
ATOM   1797 C  CB    . ARG A 1 239 ? -42.736 -4.573  -10.099 1.00 68.84  ? 248 ARG A CB    1 
ATOM   1798 C  CG    . ARG A 1 239 ? -42.986 -4.073  -8.686  1.00 73.53  ? 248 ARG A CG    1 
ATOM   1799 C  CD    . ARG A 1 239 ? -43.926 -5.004  -7.939  1.00 79.87  ? 248 ARG A CD    1 
ATOM   1800 N  NE    . ARG A 1 239 ? -43.189 -6.104  -7.323  1.00 80.44  ? 248 ARG A NE    1 
ATOM   1801 C  CZ    . ARG A 1 239 ? -43.637 -6.870  -6.333  1.00 79.59  ? 248 ARG A CZ    1 
ATOM   1802 N  NH1   . ARG A 1 239 ? -44.839 -6.666  -5.820  1.00 87.05  ? 248 ARG A NH1   1 
ATOM   1803 N  NH2   . ARG A 1 239 ? -42.874 -7.842  -5.858  1.00 78.82  ? 248 ARG A NH2   1 
ATOM   1804 N  N     . HIS A 1 240 ? -39.543 -3.501  -9.564  1.00 62.13  ? 249 HIS A N     1 
ATOM   1805 C  CA    . HIS A 1 240 ? -38.636 -2.785  -8.639  1.00 59.36  ? 249 HIS A CA    1 
ATOM   1806 C  C     . HIS A 1 240 ? -37.691 -1.853  -9.398  1.00 58.37  ? 249 HIS A C     1 
ATOM   1807 O  O     . HIS A 1 240 ? -37.028 -1.037  -8.747  1.00 50.67  ? 249 HIS A O     1 
ATOM   1808 C  CB    . HIS A 1 240 ? -37.870 -3.789  -7.799  1.00 64.75  ? 249 HIS A CB    1 
ATOM   1809 C  CG    . HIS A 1 240 ? -38.644 -4.275  -6.628  1.00 71.22  ? 249 HIS A CG    1 
ATOM   1810 N  ND1   . HIS A 1 240 ? -39.362 -5.451  -6.669  1.00 71.75  ? 249 HIS A ND1   1 
ATOM   1811 C  CD2   . HIS A 1 240 ? -38.785 -3.765  -5.384  1.00 64.60  ? 249 HIS A CD2   1 
ATOM   1812 C  CE1   . HIS A 1 240 ? -39.891 -5.663  -5.484  1.00 71.01  ? 249 HIS A CE1   1 
ATOM   1813 N  NE2   . HIS A 1 240 ? -39.543 -4.641  -4.679  1.00 74.95  ? 249 HIS A NE2   1 
ATOM   1814 N  N     . ALA A 1 241 ? -37.625 -1.965  -10.721 1.00 50.50  ? 250 ALA A N     1 
ATOM   1815 C  CA    . ALA A 1 241 ? -36.633 -1.250  -11.540 1.00 44.57  ? 250 ALA A CA    1 
ATOM   1816 C  C     . ALA A 1 241 ? -37.046 0.210   -11.623 1.00 46.45  ? 250 ALA A C     1 
ATOM   1817 O  O     . ALA A 1 241 ? -38.241 0.458   -11.511 1.00 48.94  ? 250 ALA A O     1 
ATOM   1818 C  CB    . ALA A 1 241 ? -36.552 -1.876  -12.911 1.00 47.87  ? 250 ALA A CB    1 
ATOM   1819 N  N     . ASP A 1 242 ? -36.085 1.118   -11.829 1.00 49.36  ? 251 ASP A N     1 
ATOM   1820 C  CA    . ASP A 1 242 ? -36.334 2.531   -12.204 1.00 48.55  ? 251 ASP A CA    1 
ATOM   1821 C  C     . ASP A 1 242 ? -36.244 2.649   -13.731 1.00 52.13  ? 251 ASP A C     1 
ATOM   1822 O  O     . ASP A 1 242 ? -36.668 3.664   -14.274 1.00 51.90  ? 251 ASP A O     1 
ATOM   1823 C  CB    . ASP A 1 242 ? -35.351 3.453   -11.484 1.00 52.97  ? 251 ASP A CB    1 
ATOM   1824 C  CG    . ASP A 1 242 ? -35.312 3.277   -9.965  1.00 54.62  ? 251 ASP A CG    1 
ATOM   1825 O  OD1   . ASP A 1 242 ? -36.212 3.814   -9.289  1.00 49.34  ? 251 ASP A OD1   1 
ATOM   1826 O  OD2   . ASP A 1 242 ? -34.371 2.603   -9.460  1.00 51.36  ? 251 ASP A OD2   1 
ATOM   1827 N  N     . LEU A 1 243 ? -35.689 1.649   -14.411 1.00 54.24  ? 252 LEU A N     1 
ATOM   1828 C  CA    . LEU A 1 243 ? -35.502 1.670   -15.888 1.00 55.32  ? 252 LEU A CA    1 
ATOM   1829 C  C     . LEU A 1 243 ? -35.439 0.227   -16.420 1.00 47.10  ? 252 LEU A C     1 
ATOM   1830 O  O     . LEU A 1 243 ? -34.694 -0.569  -15.885 1.00 45.19  ? 252 LEU A O     1 
ATOM   1831 C  CB    . LEU A 1 243 ? -34.233 2.481   -16.187 1.00 55.58  ? 252 LEU A CB    1 
ATOM   1832 C  CG    . LEU A 1 243 ? -33.807 2.602   -17.653 1.00 50.63  ? 252 LEU A CG    1 
ATOM   1833 C  CD1   . LEU A 1 243 ? -34.848 3.353   -18.478 1.00 46.55  ? 252 LEU A CD1   1 
ATOM   1834 C  CD2   . LEU A 1 243 ? -32.442 3.265   -17.759 1.00 45.62  ? 252 LEU A CD2   1 
ATOM   1835 N  N     . ARG A 1 244 ? -36.301 -0.128  -17.361 1.00 47.38  ? 253 ARG A N     1 
ATOM   1836 C  CA    . ARG A 1 244 ? -36.301 -1.471  -17.983 1.00 47.04  ? 253 ARG A CA    1 
ATOM   1837 C  C     . ARG A 1 244 ? -36.002 -1.261  -19.465 1.00 41.19  ? 253 ARG A C     1 
ATOM   1838 O  O     . ARG A 1 244 ? -36.652 -0.451  -20.094 1.00 49.81  ? 253 ARG A O     1 
ATOM   1839 C  CB    . ARG A 1 244 ? -37.629 -2.214  -17.802 1.00 53.02  ? 253 ARG A CB    1 
ATOM   1840 C  CG    . ARG A 1 244 ? -38.092 -2.444  -16.369 1.00 59.17  ? 253 ARG A CG    1 
ATOM   1841 C  CD    . ARG A 1 244 ? -39.589 -2.784  -16.262 1.00 56.51  ? 253 ARG A CD    1 
ATOM   1842 N  NE    . ARG A 1 244 ? -40.402 -1.615  -16.542 1.00 60.66  ? 253 ARG A NE    1 
ATOM   1843 C  CZ    . ARG A 1 244 ? -40.663 -0.640  -15.672 1.00 73.69  ? 253 ARG A CZ    1 
ATOM   1844 N  NH1   . ARG A 1 244 ? -41.380 0.401   -16.051 1.00 71.35  ? 253 ARG A NH1   1 
ATOM   1845 N  NH2   . ARG A 1 244 ? -40.217 -0.700  -14.423 1.00 80.76  ? 253 ARG A NH2   1 
ATOM   1846 N  N     . ILE A 1 245 ? -35.040 -1.975  -19.999 1.00 41.40  ? 254 ILE A N     1 
ATOM   1847 C  CA    . ILE A 1 245 ? -34.624 -1.823  -21.414 1.00 41.19  ? 254 ILE A CA    1 
ATOM   1848 C  C     . ILE A 1 245 ? -34.790 -3.193  -22.064 1.00 40.47  ? 254 ILE A C     1 
ATOM   1849 O  O     . ILE A 1 245 ? -34.083 -4.112  -21.660 1.00 43.55  ? 254 ILE A O     1 
ATOM   1850 C  CB    . ILE A 1 245 ? -33.180 -1.302  -21.464 1.00 39.24  ? 254 ILE A CB    1 
ATOM   1851 C  CG1   . ILE A 1 245 ? -33.001 -0.125  -20.501 1.00 39.82  ? 254 ILE A CG1   1 
ATOM   1852 C  CG2   . ILE A 1 245 ? -32.782 -0.975  -22.886 1.00 39.05  ? 254 ILE A CG2   1 
ATOM   1853 C  CD1   . ILE A 1 245 ? -31.708 0.626   -20.623 1.00 38.24  ? 254 ILE A CD1   1 
ATOM   1854 N  N     . HIS A 1 246 ? -35.712 -3.277  -23.011 1.00 42.56  ? 255 HIS A N     1 
ATOM   1855 C  CA    . HIS A 1 246 ? -36.032 -4.472  -23.819 1.00 45.66  ? 255 HIS A CA    1 
ATOM   1856 C  C     . HIS A 1 246 ? -35.272 -4.368  -25.153 1.00 40.68  ? 255 HIS A C     1 
ATOM   1857 O  O     . HIS A 1 246 ? -35.801 -3.848  -26.147 1.00 39.68  ? 255 HIS A O     1 
ATOM   1858 C  CB    . HIS A 1 246 ? -37.561 -4.623  -23.863 1.00 40.37  ? 255 HIS A CB    1 
ATOM   1859 C  CG    . HIS A 1 246 ? -38.167 -4.695  -22.502 1.00 49.06  ? 255 HIS A CG    1 
ATOM   1860 N  ND1   . HIS A 1 246 ? -39.139 -3.799  -22.062 1.00 53.75  ? 255 HIS A ND1   1 
ATOM   1861 C  CD2   . HIS A 1 246 ? -37.940 -5.542  -21.467 1.00 48.25  ? 255 HIS A CD2   1 
ATOM   1862 C  CE1   . HIS A 1 246 ? -39.482 -4.100  -20.827 1.00 47.10  ? 255 HIS A CE1   1 
ATOM   1863 N  NE2   . HIS A 1 246 ? -38.768 -5.178  -20.445 1.00 48.03  ? 255 HIS A NE2   1 
ATOM   1864 N  N     . GLY A 1 247 ? -34.052 -4.891  -25.170 1.00 43.29  ? 256 GLY A N     1 
ATOM   1865 C  CA    . GLY A 1 247 ? -33.236 -5.009  -26.387 1.00 38.27  ? 256 GLY A CA    1 
ATOM   1866 C  C     . GLY A 1 247 ? -32.058 -5.921  -26.176 1.00 39.85  ? 256 GLY A C     1 
ATOM   1867 O  O     . GLY A 1 247 ? -31.864 -6.375  -25.030 1.00 36.86  ? 256 GLY A O     1 
ATOM   1868 N  N     . TYR A 1 248 ? -31.298 -6.172  -27.249 1.00 41.01  ? 257 TYR A N     1 
ATOM   1869 C  CA    . TYR A 1 248 ? -30.073 -7.006  -27.228 1.00 43.49  ? 257 TYR A CA    1 
ATOM   1870 C  C     . TYR A 1 248 ? -29.011 -6.278  -26.415 1.00 44.06  ? 257 TYR A C     1 
ATOM   1871 O  O     . TYR A 1 248 ? -28.676 -5.139  -26.806 1.00 45.67  ? 257 TYR A O     1 
ATOM   1872 C  CB    . TYR A 1 248 ? -29.614 -7.297  -28.656 1.00 43.01  ? 257 TYR A CB    1 
ATOM   1873 C  CG    . TYR A 1 248 ? -30.621 -8.090  -29.457 1.00 46.41  ? 257 TYR A CG    1 
ATOM   1874 C  CD1   . TYR A 1 248 ? -30.859 -9.424  -29.161 1.00 47.68  ? 257 TYR A CD1   1 
ATOM   1875 C  CD2   . TYR A 1 248 ? -31.337 -7.515  -30.501 1.00 46.40  ? 257 TYR A CD2   1 
ATOM   1876 C  CE1   . TYR A 1 248 ? -31.762 -10.175 -29.898 1.00 47.45  ? 257 TYR A CE1   1 
ATOM   1877 C  CE2   . TYR A 1 248 ? -32.266 -8.245  -31.229 1.00 43.04  ? 257 TYR A CE2   1 
ATOM   1878 C  CZ    . TYR A 1 248 ? -32.477 -9.578  -30.921 1.00 43.65  ? 257 TYR A CZ    1 
ATOM   1879 O  OH    . TYR A 1 248 ? -33.397 -10.321 -31.594 1.00 43.01  ? 257 TYR A OH    1 
ATOM   1880 N  N     . VAL A 1 249 ? -28.483 -6.925  -25.371 1.00 39.90  ? 258 VAL A N     1 
ATOM   1881 C  CA    . VAL A 1 249 ? -27.401 -6.362  -24.499 1.00 39.96  ? 258 VAL A CA    1 
ATOM   1882 C  C     . VAL A 1 249 ? -26.198 -5.822  -25.269 1.00 36.77  ? 258 VAL A C     1 
ATOM   1883 O  O     . VAL A 1 249 ? -25.622 -4.835  -24.770 1.00 34.79  ? 258 VAL A O     1 
ATOM   1884 C  CB    . VAL A 1 249 ? -26.936 -7.335  -23.408 1.00 41.11  ? 258 VAL A CB    1 
ATOM   1885 C  CG1   . VAL A 1 249 ? -28.044 -7.480  -22.375 1.00 46.55  ? 258 VAL A CG1   1 
ATOM   1886 C  CG2   . VAL A 1 249 ? -26.495 -8.681  -23.925 1.00 40.24  ? 258 VAL A CG2   1 
ATOM   1887 N  N     . ASP A 1 250 ? -25.865 -6.365  -26.444 1.00 39.92  ? 259 ASP A N     1 
ATOM   1888 C  CA    . ASP A 1 250 ? -24.735 -5.863  -27.282 1.00 42.34  ? 259 ASP A CA    1 
ATOM   1889 C  C     . ASP A 1 250 ? -25.047 -4.450  -27.819 1.00 42.19  ? 259 ASP A C     1 
ATOM   1890 O  O     . ASP A 1 250 ? -24.206 -3.550  -27.651 1.00 44.52  ? 259 ASP A O     1 
ATOM   1891 C  CB    . ASP A 1 250 ? -24.367 -6.886  -28.361 1.00 40.97  ? 259 ASP A CB    1 
ATOM   1892 C  CG    . ASP A 1 250 ? -23.481 -8.020  -27.853 1.00 41.73  ? 259 ASP A CG    1 
ATOM   1893 O  OD1   . ASP A 1 250 ? -22.979 -7.936  -26.690 1.00 39.65  ? 259 ASP A OD1   1 
ATOM   1894 O  OD2   . ASP A 1 250 ? -23.285 -8.995  -28.623 1.00 46.24  ? 259 ASP A OD2   1 
ATOM   1895 N  N     . GLU A 1 251 ? -26.205 -4.276  -28.451 1.00 47.82  ? 260 GLU A N     1 
ATOM   1896 C  CA    . GLU A 1 251 ? -26.742 -2.988  -28.984 1.00 46.78  ? 260 GLU A CA    1 
ATOM   1897 C  C     . GLU A 1 251 ? -26.765 -1.971  -27.833 1.00 44.39  ? 260 GLU A C     1 
ATOM   1898 O  O     . GLU A 1 251 ? -26.193 -0.869  -27.936 1.00 42.27  ? 260 GLU A O     1 
ATOM   1899 C  CB    . GLU A 1 251 ? -28.128 -3.255  -29.605 1.00 47.95  ? 260 GLU A CB    1 
ATOM   1900 C  CG    . GLU A 1 251 ? -28.823 -2.005  -30.146 1.00 55.74  ? 260 GLU A CG    1 
ATOM   1901 C  CD    . GLU A 1 251 ? -29.754 -2.148  -31.357 1.00 53.83  ? 260 GLU A CD    1 
ATOM   1902 O  OE1   . GLU A 1 251 ? -29.448 -2.923  -32.354 1.00 49.66  ? 260 GLU A OE1   1 
ATOM   1903 O  OE2   . GLU A 1 251 ? -30.752 -1.421  -31.350 1.00 57.51  ? 260 GLU A OE2   1 
ATOM   1904 N  N     . VAL A 1 252 ? -27.354 -2.342  -26.706 1.00 46.94  ? 261 VAL A N     1 
ATOM   1905 C  CA    . VAL A 1 252 ? -27.415 -1.451  -25.508 1.00 39.30  ? 261 VAL A CA    1 
ATOM   1906 C  C     . VAL A 1 252 ? -25.986 -1.069  -25.078 1.00 35.96  ? 261 VAL A C     1 
ATOM   1907 O  O     . VAL A 1 252 ? -25.697 0.125   -25.017 1.00 36.55  ? 261 VAL A O     1 
ATOM   1908 C  CB    . VAL A 1 252 ? -28.186 -2.142  -24.391 1.00 36.64  ? 261 VAL A CB    1 
ATOM   1909 C  CG1   . VAL A 1 252 ? -28.177 -1.353  -23.092 1.00 41.46  ? 261 VAL A CG1   1 
ATOM   1910 C  CG2   . VAL A 1 252 ? -29.585 -2.447  -24.851 1.00 39.32  ? 261 VAL A CG2   1 
ATOM   1911 N  N     . MET A 1 253 ? -25.110 -2.038  -24.835 1.00 30.79  ? 262 MET A N     1 
ATOM   1912 C  CA    . MET A 1 253 ? -23.748 -1.748  -24.344 1.00 34.23  ? 262 MET A CA    1 
ATOM   1913 C  C     . MET A 1 253 ? -22.931 -0.950  -25.377 1.00 41.20  ? 262 MET A C     1 
ATOM   1914 O  O     . MET A 1 253 ? -22.144 -0.103  -24.939 1.00 42.61  ? 262 MET A O     1 
ATOM   1915 C  CB    . MET A 1 253 ? -23.045 -3.047  -23.975 1.00 34.51  ? 262 MET A CB    1 
ATOM   1916 C  CG    . MET A 1 253 ? -23.642 -3.684  -22.743 1.00 38.74  ? 262 MET A CG    1 
ATOM   1917 S  SD    . MET A 1 253 ? -23.934 -2.555  -21.354 1.00 44.60  ? 262 MET A SD    1 
ATOM   1918 C  CE    . MET A 1 253 ? -22.376 -2.786  -20.497 1.00 43.96  ? 262 MET A CE    1 
ATOM   1919 N  N     . THR A 1 254 ? -23.078 -1.191  -26.690 1.00 41.24  ? 263 THR A N     1 
ATOM   1920 C  CA    . THR A 1 254 ? -22.307 -0.451  -27.725 1.00 43.09  ? 263 THR A CA    1 
ATOM   1921 C  C     . THR A 1 254 ? -22.795 1.018   -27.759 1.00 44.68  ? 263 THR A C     1 
ATOM   1922 O  O     . THR A 1 254 ? -21.944 1.952   -27.778 1.00 46.45  ? 263 THR A O     1 
ATOM   1923 C  CB    . THR A 1 254 ? -22.312 -1.210  -29.063 1.00 40.92  ? 263 THR A CB    1 
ATOM   1924 O  OG1   . THR A 1 254 ? -23.637 -1.492  -29.472 1.00 48.28  ? 263 THR A OG1   1 
ATOM   1925 C  CG2   . THR A 1 254 ? -21.647 -2.565  -29.002 1.00 41.81  ? 263 THR A CG2   1 
ATOM   1926 N  N     . ARG A 1 255 ? -24.105 1.255   -27.720 1.00 41.11  ? 264 ARG A N     1 
ATOM   1927 C  CA    . ARG A 1 255 ? -24.668 2.622   -27.583 1.00 41.89  ? 264 ARG A CA    1 
ATOM   1928 C  C     . ARG A 1 255 ? -24.176 3.292   -26.291 1.00 40.70  ? 264 ARG A C     1 
ATOM   1929 O  O     . ARG A 1 255 ? -23.734 4.461   -26.354 1.00 39.98  ? 264 ARG A O     1 
ATOM   1930 C  CB    . ARG A 1 255 ? -26.192 2.552   -27.647 1.00 47.34  ? 264 ARG A CB    1 
ATOM   1931 C  CG    . ARG A 1 255 ? -26.656 2.287   -29.069 1.00 54.83  ? 264 ARG A CG    1 
ATOM   1932 C  CD    . ARG A 1 255 ? -28.089 1.880   -29.217 1.00 54.95  ? 264 ARG A CD    1 
ATOM   1933 N  NE    . ARG A 1 255 ? -28.332 1.682   -30.634 1.00 58.78  ? 264 ARG A NE    1 
ATOM   1934 C  CZ    . ARG A 1 255 ? -29.489 1.901   -31.247 1.00 74.17  ? 264 ARG A CZ    1 
ATOM   1935 N  NH1   . ARG A 1 255 ? -30.545 2.356   -30.579 1.00 68.02  ? 264 ARG A NH1   1 
ATOM   1936 N  NH2   . ARG A 1 255 ? -29.568 1.680   -32.548 1.00 80.64  ? 264 ARG A NH2   1 
ATOM   1937 N  N     . LEU A 1 256 ? -24.234 2.582   -25.171 1.00 36.26  ? 265 LEU A N     1 
ATOM   1938 C  CA    . LEU A 1 256 ? -23.861 3.137   -23.850 1.00 40.90  ? 265 LEU A CA    1 
ATOM   1939 C  C     . LEU A 1 256 ? -22.413 3.627   -23.911 1.00 37.68  ? 265 LEU A C     1 
ATOM   1940 O  O     . LEU A 1 256 ? -22.145 4.743   -23.458 1.00 41.86  ? 265 LEU A O     1 
ATOM   1941 C  CB    . LEU A 1 256 ? -24.056 2.067   -22.770 1.00 39.62  ? 265 LEU A CB    1 
ATOM   1942 C  CG    . LEU A 1 256 ? -23.630 2.502   -21.375 1.00 43.85  ? 265 LEU A CG    1 
ATOM   1943 C  CD1   . LEU A 1 256 ? -24.613 3.513   -20.825 1.00 49.27  ? 265 LEU A CD1   1 
ATOM   1944 C  CD2   . LEU A 1 256 ? -23.517 1.307   -20.436 1.00 45.70  ? 265 LEU A CD2   1 
ATOM   1945 N  N     . MET A 1 257 ? -21.510 2.815   -24.458 1.00 42.61  ? 266 MET A N     1 
ATOM   1946 C  CA    . MET A 1 257 ? -20.059 3.103   -24.456 1.00 42.86  ? 266 MET A CA    1 
ATOM   1947 C  C     . MET A 1 257 ? -19.837 4.336   -25.330 1.00 47.26  ? 266 MET A C     1 
ATOM   1948 O  O     . MET A 1 257 ? -19.013 5.229   -24.946 1.00 53.63  ? 266 MET A O     1 
ATOM   1949 C  CB    . MET A 1 257 ? -19.245 1.935   -25.015 1.00 43.56  ? 266 MET A CB    1 
ATOM   1950 C  CG    . MET A 1 257 ? -19.238 0.719   -24.132 1.00 42.40  ? 266 MET A CG    1 
ATOM   1951 S  SD    . MET A 1 257 ? -18.730 1.083   -22.443 1.00 41.20  ? 266 MET A SD    1 
ATOM   1952 C  CE    . MET A 1 257 ? -17.031 0.531   -22.487 1.00 50.68  ? 266 MET A CE    1 
ATOM   1953 N  N     . LYS A 1 258 ? -20.567 4.393   -26.447 1.00 44.21  ? 267 LYS A N     1 
ATOM   1954 C  CA    . LYS A 1 258 ? -20.473 5.510   -27.405 1.00 43.30  ? 267 LYS A CA    1 
ATOM   1955 C  C     . LYS A 1 258 ? -20.869 6.763   -26.642 1.00 37.87  ? 267 LYS A C     1 
ATOM   1956 O  O     . LYS A 1 258 ? -20.129 7.751   -26.724 1.00 44.30  ? 267 LYS A O     1 
ATOM   1957 C  CB    . LYS A 1 258 ? -21.314 5.298   -28.668 1.00 52.95  ? 267 LYS A CB    1 
ATOM   1958 C  CG    . LYS A 1 258 ? -21.216 6.446   -29.664 1.00 59.96  ? 267 LYS A CG    1 
ATOM   1959 C  CD    . LYS A 1 258 ? -22.049 6.271   -30.917 1.00 70.31  ? 267 LYS A CD    1 
ATOM   1960 C  CE    . LYS A 1 258 ? -21.962 7.473   -31.841 1.00 68.70  ? 267 LYS A CE    1 
ATOM   1961 N  NZ    . LYS A 1 258 ? -23.236 7.677   -32.577 1.00 67.38  ? 267 LYS A NZ    1 
ATOM   1962 N  N     . HIS A 1 259 ? -21.961 6.728   -25.889 1.00 40.15  ? 268 HIS A N     1 
ATOM   1963 C  CA    . HIS A 1 259 ? -22.418 7.917   -25.117 1.00 40.38  ? 268 HIS A CA    1 
ATOM   1964 C  C     . HIS A 1 259 ? -21.361 8.301   -24.096 1.00 41.05  ? 268 HIS A C     1 
ATOM   1965 O  O     . HIS A 1 259 ? -21.248 9.518   -23.802 1.00 44.18  ? 268 HIS A O     1 
ATOM   1966 C  CB    . HIS A 1 259 ? -23.782 7.692   -24.480 1.00 38.76  ? 268 HIS A CB    1 
ATOM   1967 C  CG    . HIS A 1 259 ? -24.839 7.560   -25.507 1.00 44.46  ? 268 HIS A CG    1 
ATOM   1968 N  ND1   . HIS A 1 259 ? -24.597 7.853   -26.830 1.00 49.10  ? 268 HIS A ND1   1 
ATOM   1969 C  CD2   . HIS A 1 259 ? -26.114 7.142   -25.430 1.00 51.85  ? 268 HIS A CD2   1 
ATOM   1970 C  CE1   . HIS A 1 259 ? -25.690 7.645   -27.524 1.00 60.05  ? 268 HIS A CE1   1 
ATOM   1971 N  NE2   . HIS A 1 259 ? -26.640 7.228   -26.689 1.00 57.00  ? 268 HIS A NE2   1 
ATOM   1972 N  N     . LEU A 1 260 ? -20.651 7.305   -23.562 1.00 38.84  ? 269 LEU A N     1 
ATOM   1973 C  CA    . LEU A 1 260 ? -19.646 7.530   -22.497 1.00 43.00  ? 269 LEU A CA    1 
ATOM   1974 C  C     . LEU A 1 260 ? -18.327 7.981   -23.107 1.00 37.96  ? 269 LEU A C     1 
ATOM   1975 O  O     . LEU A 1 260 ? -17.459 8.317   -22.330 1.00 44.68  ? 269 LEU A O     1 
ATOM   1976 C  CB    . LEU A 1 260 ? -19.428 6.242   -21.682 1.00 42.36  ? 269 LEU A CB    1 
ATOM   1977 C  CG    . LEU A 1 260 ? -20.613 5.802   -20.840 1.00 37.78  ? 269 LEU A CG    1 
ATOM   1978 C  CD1   . LEU A 1 260 ? -20.352 4.465   -20.203 1.00 36.49  ? 269 LEU A CD1   1 
ATOM   1979 C  CD2   . LEU A 1 260 ? -20.960 6.841   -19.813 1.00 38.82  ? 269 LEU A CD2   1 
ATOM   1980 N  N     . GLY A 1 261 ? -18.164 7.883   -24.426 1.00 44.73  ? 270 GLY A N     1 
ATOM   1981 C  CA    . GLY A 1 261 ? -16.905 8.210   -25.124 1.00 43.80  ? 270 GLY A CA    1 
ATOM   1982 C  C     . GLY A 1 261 ? -15.785 7.228   -24.789 1.00 45.31  ? 270 GLY A C     1 
ATOM   1983 O  O     . GLY A 1 261 ? -14.665 7.657   -24.598 1.00 47.66  ? 270 GLY A O     1 
ATOM   1984 N  N     . LEU A 1 262 ? -16.083 5.932   -24.745 1.00 51.47  ? 271 LEU A N     1 
ATOM   1985 C  CA    . LEU A 1 262 ? -15.112 4.854   -24.417 1.00 50.33  ? 271 LEU A CA    1 
ATOM   1986 C  C     . LEU A 1 262 ? -15.048 3.895   -25.606 1.00 50.29  ? 271 LEU A C     1 
ATOM   1987 O  O     . LEU A 1 262 ? -16.065 3.724   -26.285 1.00 52.32  ? 271 LEU A O     1 
ATOM   1988 C  CB    . LEU A 1 262 ? -15.552 4.128   -23.140 1.00 45.17  ? 271 LEU A CB    1 
ATOM   1989 C  CG    . LEU A 1 262 ? -15.491 4.943   -21.843 1.00 49.60  ? 271 LEU A CG    1 
ATOM   1990 C  CD1   . LEU A 1 262 ? -16.115 4.182   -20.681 1.00 47.23  ? 271 LEU A CD1   1 
ATOM   1991 C  CD2   . LEU A 1 262 ? -14.078 5.313   -21.477 1.00 50.56  ? 271 LEU A CD2   1 
ATOM   1992 N  N     . GLU A 1 263 ? -13.880 3.323   -25.879 1.00 52.67  ? 272 GLU A N     1 
ATOM   1993 C  CA    . GLU A 1 263 ? -13.749 2.330   -26.961 1.00 57.53  ? 272 GLU A CA    1 
ATOM   1994 C  C     . GLU A 1 263 ? -13.811 0.954   -26.296 1.00 54.71  ? 272 GLU A C     1 
ATOM   1995 O  O     . GLU A 1 263 ? -13.420 0.834   -25.118 1.00 52.26  ? 272 GLU A O     1 
ATOM   1996 C  CB    . GLU A 1 263 ? -12.525 2.624   -27.827 1.00 63.12  ? 272 GLU A CB    1 
ATOM   1997 C  CG    . GLU A 1 263 ? -11.319 1.744   -27.553 1.00 73.62  ? 272 GLU A CG    1 
ATOM   1998 C  CD    . GLU A 1 263 ? -10.426 1.574   -28.770 1.00 76.87  ? 272 GLU A CD    1 
ATOM   1999 O  OE1   . GLU A 1 263 ? -10.957 1.429   -29.897 1.00 77.60  ? 272 GLU A OE1   1 
ATOM   2000 O  OE2   . GLU A 1 263 ? -9.212  1.614   -28.592 1.00 71.87  ? 272 GLU A OE2   1 
ATOM   2001 N  N     . ILE A 1 264 ? -14.383 -0.010  -27.007 1.00 50.07  ? 273 ILE A N     1 
ATOM   2002 C  CA    . ILE A 1 264 ? -14.511 -1.410  -26.538 1.00 48.64  ? 273 ILE A CA    1 
ATOM   2003 C  C     . ILE A 1 264 ? -13.241 -2.116  -26.981 1.00 47.79  ? 273 ILE A C     1 
ATOM   2004 O  O     . ILE A 1 264 ? -12.936 -2.182  -28.163 1.00 44.10  ? 273 ILE A O     1 
ATOM   2005 C  CB    . ILE A 1 264 ? -15.809 -2.064  -27.041 1.00 47.30  ? 273 ILE A CB    1 
ATOM   2006 C  CG1   . ILE A 1 264 ? -17.036 -1.302  -26.522 1.00 43.31  ? 273 ILE A CG1   1 
ATOM   2007 C  CG2   . ILE A 1 264 ? -15.835 -3.535  -26.666 1.00 57.92  ? 273 ILE A CG2   1 
ATOM   2008 C  CD1   . ILE A 1 264 ? -18.365 -2.000  -26.693 1.00 39.65  ? 273 ILE A CD1   1 
ATOM   2009 N  N     . PRO A 1 265 ? -12.459 -2.625  -26.015 1.00 48.28  ? 274 PRO A N     1 
ATOM   2010 C  CA    . PRO A 1 265 ? -11.149 -3.217  -26.285 1.00 50.34  ? 274 PRO A CA    1 
ATOM   2011 C  C     . PRO A 1 265 ? -11.145 -4.541  -27.058 1.00 49.28  ? 274 PRO A C     1 
ATOM   2012 O  O     . PRO A 1 265 ? -11.959 -5.390  -26.807 1.00 47.38  ? 274 PRO A O     1 
ATOM   2013 C  CB    . PRO A 1 265 ? -10.601 -3.631  -24.908 1.00 49.36  ? 274 PRO A CB    1 
ATOM   2014 C  CG    . PRO A 1 265 ? -11.544 -3.022  -23.889 1.00 53.55  ? 274 PRO A CG    1 
ATOM   2015 C  CD    . PRO A 1 265 ? -12.836 -2.686  -24.600 1.00 46.34  ? 274 PRO A CD    1 
ATOM   2016 N  N     . ALA A 1 266 ? -10.155 -4.696  -27.924 1.00 52.48  ? 275 ALA A N     1 
ATOM   2017 C  CA    . ALA A 1 266 ? -9.759  -5.976  -28.539 1.00 50.69  ? 275 ALA A CA    1 
ATOM   2018 C  C     . ALA A 1 266 ? -9.547  -7.019  -27.434 1.00 54.59  ? 275 ALA A C     1 
ATOM   2019 O  O     . ALA A 1 266 ? -9.106  -6.652  -26.310 1.00 50.98  ? 275 ALA A O     1 
ATOM   2020 C  CB    . ALA A 1 266 ? -8.491  -5.784  -29.368 1.00 47.34  ? 275 ALA A CB    1 
ATOM   2021 N  N     . TRP A 1 267 ? -9.790  -8.284  -27.787 1.00 49.44  ? 276 TRP A N     1 
ATOM   2022 C  CA    . TRP A 1 267 ? -9.586  -9.469  -26.929 1.00 46.73  ? 276 TRP A CA    1 
ATOM   2023 C  C     . TRP A 1 267 ? -8.349  -10.209 -27.417 1.00 58.34  ? 276 TRP A C     1 
ATOM   2024 O  O     . TRP A 1 267 ? -8.445  -10.902 -28.460 1.00 61.59  ? 276 TRP A O     1 
ATOM   2025 C  CB    . TRP A 1 267 ? -10.836 -10.349 -26.937 1.00 43.60  ? 276 TRP A CB    1 
ATOM   2026 C  CG    . TRP A 1 267 ? -10.725 -11.592 -26.117 1.00 40.65  ? 276 TRP A CG    1 
ATOM   2027 C  CD1   . TRP A 1 267 ? -10.562 -11.685 -24.767 1.00 39.86  ? 276 TRP A CD1   1 
ATOM   2028 C  CD2   . TRP A 1 267 ? -10.783 -12.940 -26.611 1.00 45.08  ? 276 TRP A CD2   1 
ATOM   2029 N  NE1   . TRP A 1 267 ? -10.462 -12.996 -24.395 1.00 38.30  ? 276 TRP A NE1   1 
ATOM   2030 C  CE2   . TRP A 1 267 ? -10.651 -13.790 -25.495 1.00 44.11  ? 276 TRP A CE2   1 
ATOM   2031 C  CE3   . TRP A 1 267 ? -10.970 -13.513 -27.875 1.00 43.30  ? 276 TRP A CE3   1 
ATOM   2032 C  CZ2   . TRP A 1 267 ? -10.715 -15.181 -25.610 1.00 42.36  ? 276 TRP A CZ2   1 
ATOM   2033 C  CZ3   . TRP A 1 267 ? -10.986 -14.885 -27.984 1.00 40.86  ? 276 TRP A CZ3   1 
ATOM   2034 C  CH2   . TRP A 1 267 ? -10.820 -15.703 -26.870 1.00 39.24  ? 276 TRP A CH2   1 
ATOM   2035 N  N     . ASP A 1 268 ? -7.266  -10.115 -26.636 1.00 64.49  ? 277 ASP A N     1 
ATOM   2036 C  CA    . ASP A 1 268 ? -5.941  -10.695 -26.966 1.00 69.45  ? 277 ASP A CA    1 
ATOM   2037 C  C     . ASP A 1 268 ? -6.033  -12.219 -27.057 1.00 58.52  ? 277 ASP A C     1 
ATOM   2038 O  O     . ASP A 1 268 ? -5.065  -12.806 -27.543 1.00 60.72  ? 277 ASP A O     1 
ATOM   2039 C  CB    . ASP A 1 268 ? -4.871  -10.282 -25.948 1.00 85.22  ? 277 ASP A CB    1 
ATOM   2040 C  CG    . ASP A 1 268 ? -3.860  -9.285  -26.497 1.00 93.81  ? 277 ASP A CG    1 
ATOM   2041 O  OD1   . ASP A 1 268 ? -3.503  -9.404  -27.704 1.00 88.11  ? 277 ASP A OD1   1 
ATOM   2042 O  OD2   . ASP A 1 268 ? -3.433  -8.396  -25.718 1.00 94.70  ? 277 ASP A OD2   1 
ATOM   2043 N  N     . GLY A 1 269 ? -7.151  -12.822 -26.648 1.00 50.68  ? 278 GLY A N     1 
ATOM   2044 C  CA    . GLY A 1 269 ? -7.283  -14.283 -26.480 1.00 48.70  ? 278 GLY A CA    1 
ATOM   2045 C  C     . GLY A 1 269 ? -7.404  -14.613 -24.992 1.00 45.38  ? 278 GLY A C     1 
ATOM   2046 O  O     . GLY A 1 269 ? -7.322  -13.710 -24.161 1.00 46.79  ? 278 GLY A O     1 
ATOM   2047 N  N     . PRO A 1 270 ? -7.538  -15.907 -24.620 1.00 45.89  ? 279 PRO A N     1 
ATOM   2048 C  CA    . PRO A 1 270 ? -7.751  -16.317 -23.227 1.00 42.35  ? 279 PRO A CA    1 
ATOM   2049 C  C     . PRO A 1 270 ? -6.660  -15.775 -22.289 1.00 43.88  ? 279 PRO A C     1 
ATOM   2050 O  O     . PRO A 1 270 ? -5.506  -16.107 -22.480 1.00 43.42  ? 279 PRO A O     1 
ATOM   2051 C  CB    . PRO A 1 270 ? -7.678  -17.858 -23.257 1.00 45.33  ? 279 PRO A CB    1 
ATOM   2052 C  CG    . PRO A 1 270 ? -7.872  -18.262 -24.719 1.00 48.92  ? 279 PRO A CG    1 
ATOM   2053 C  CD    . PRO A 1 270 ? -7.437  -17.058 -25.536 1.00 49.82  ? 279 PRO A CD    1 
ATOM   2054 N  N     . ARG A 1 271 ? -7.027  -14.970 -21.294 1.00 43.57  ? 280 ARG A N     1 
ATOM   2055 C  CA    . ARG A 1 271 ? -6.038  -14.295 -20.416 1.00 49.00  ? 280 ARG A CA    1 
ATOM   2056 C  C     . ARG A 1 271 ? -6.630  -14.098 -19.027 1.00 46.31  ? 280 ARG A C     1 
ATOM   2057 O  O     . ARG A 1 271 ? -7.641  -13.425 -18.929 1.00 52.56  ? 280 ARG A O     1 
ATOM   2058 C  CB    . ARG A 1 271 ? -5.658  -12.923 -20.985 1.00 52.17  ? 280 ARG A CB    1 
ATOM   2059 C  CG    . ARG A 1 271 ? -4.584  -12.956 -22.061 1.00 57.58  ? 280 ARG A CG    1 
ATOM   2060 C  CD    . ARG A 1 271 ? -3.313  -13.691 -21.685 1.00 57.50  ? 280 ARG A CD    1 
ATOM   2061 N  NE    . ARG A 1 271 ? -2.145  -13.285 -22.469 1.00 65.15  ? 280 ARG A NE    1 
ATOM   2062 C  CZ    . ARG A 1 271 ? -2.013  -13.442 -23.791 1.00 64.01  ? 280 ARG A CZ    1 
ATOM   2063 N  NH1   . ARG A 1 271 ? -2.992  -13.956 -24.520 1.00 52.05  ? 280 ARG A NH1   1 
ATOM   2064 N  NH2   . ARG A 1 271 ? -0.898  -13.060 -24.387 1.00 70.85  ? 280 ARG A NH2   1 
ATOM   2065 N  N     . VAL A 1 272 ? -5.949  -14.579 -17.998 1.00 47.43  ? 281 VAL A N     1 
ATOM   2066 C  CA    . VAL A 1 272 ? -6.402  -14.503 -16.581 1.00 40.31  ? 281 VAL A CA    1 
ATOM   2067 C  C     . VAL A 1 272 ? -5.730  -13.309 -15.944 1.00 35.64  ? 281 VAL A C     1 
ATOM   2068 O  O     . VAL A 1 272 ? -4.538  -13.276 -16.052 1.00 39.54  ? 281 VAL A O     1 
ATOM   2069 C  CB    . VAL A 1 272 ? -5.977  -15.743 -15.792 1.00 41.79  ? 281 VAL A CB    1 
ATOM   2070 C  CG1   . VAL A 1 272 ? -6.454  -15.663 -14.338 1.00 40.89  ? 281 VAL A CG1   1 
ATOM   2071 C  CG2   . VAL A 1 272 ? -6.410  -17.014 -16.505 1.00 38.48  ? 281 VAL A CG2   1 
ATOM   2072 N  N     . LEU A 1 273 ? -6.477  -12.445 -15.249 1.00 36.89  ? 282 LEU A N     1 
ATOM   2073 C  CA    . LEU A 1 273 ? -5.927  -11.391 -14.374 1.00 35.31  ? 282 LEU A CA    1 
ATOM   2074 C  C     . LEU A 1 273 ? -6.471  -11.528 -12.948 1.00 36.00  ? 282 LEU A C     1 
ATOM   2075 O  O     . LEU A 1 273 ? -7.638  -11.275 -12.779 1.00 40.88  ? 282 LEU A O     1 
ATOM   2076 C  CB    . LEU A 1 273 ? -6.346  -10.043 -14.966 1.00 40.74  ? 282 LEU A CB    1 
ATOM   2077 C  CG    . LEU A 1 273 ? -5.704  -8.828  -14.282 1.00 36.73  ? 282 LEU A CG    1 
ATOM   2078 C  CD1   . LEU A 1 273 ? -4.197  -8.855  -14.481 1.00 36.48  ? 282 LEU A CD1   1 
ATOM   2079 C  CD2   . LEU A 1 273 ? -6.304  -7.548  -14.820 1.00 39.14  ? 282 LEU A CD2   1 
ATOM   2080 N  N     . GLU A 1 274 ? -5.642  -11.867 -11.961 1.00 40.18  ? 283 GLU A N     1 
ATOM   2081 C  CA    . GLU A 1 274 ? -6.048  -12.111 -10.546 1.00 42.54  ? 283 GLU A CA    1 
ATOM   2082 C  C     . GLU A 1 274 ? -6.477  -10.810 -9.855  1.00 47.25  ? 283 GLU A C     1 
ATOM   2083 O  O     . GLU A 1 274 ? -7.510  -10.814 -9.182  1.00 43.71  ? 283 GLU A O     1 
ATOM   2084 C  CB    . GLU A 1 274 ? -4.898  -12.707 -9.740  1.00 48.79  ? 283 GLU A CB    1 
ATOM   2085 C  CG    . GLU A 1 274 ? -4.523  -14.116 -10.148 1.00 52.63  ? 283 GLU A CG    1 
ATOM   2086 C  CD    . GLU A 1 274 ? -5.669  -15.117 -10.179 1.00 54.77  ? 283 GLU A CD    1 
ATOM   2087 O  OE1   . GLU A 1 274 ? -6.655  -14.943 -9.417  1.00 53.05  ? 283 GLU A OE1   1 
ATOM   2088 O  OE2   . GLU A 1 274 ? -5.559  -16.081 -10.961 1.00 57.32  ? 283 GLU A OE2   1 
ATOM   2089 N  N     . ARG A 1 275 ? -5.714  -9.730  -10.032 1.00 54.49  ? 284 ARG A N     1 
ATOM   2090 C  CA    . ARG A 1 275 ? -5.858  -8.461  -9.269  1.00 53.18  ? 284 ARG A CA    1 
ATOM   2091 C  C     . ARG A 1 275 ? -5.983  -7.284  -10.241 1.00 51.72  ? 284 ARG A C     1 
ATOM   2092 O  O     . ARG A 1 275 ? -5.120  -7.181  -11.131 1.00 49.04  ? 284 ARG A O     1 
ATOM   2093 C  CB    . ARG A 1 275 ? -4.656  -8.279  -8.340  1.00 55.49  ? 284 ARG A CB    1 
ATOM   2094 C  CG    . ARG A 1 275 ? -4.650  -9.173  -7.109  1.00 60.40  ? 284 ARG A CG    1 
ATOM   2095 C  CD    . ARG A 1 275 ? -3.694  -8.587  -6.085  1.00 70.80  ? 284 ARG A CD    1 
ATOM   2096 N  NE    . ARG A 1 275 ? -3.548  -9.297  -4.814  1.00 78.13  ? 284 ARG A NE    1 
ATOM   2097 C  CZ    . ARG A 1 275 ? -4.239  -9.056  -3.696  1.00 79.82  ? 284 ARG A CZ    1 
ATOM   2098 N  NH1   . ARG A 1 275 ? -5.200  -8.144  -3.676  1.00 73.44  ? 284 ARG A NH1   1 
ATOM   2099 N  NH2   . ARG A 1 275 ? -3.972  -9.751  -2.598  1.00 77.45  ? 284 ARG A NH2   1 
ATOM   2100 N  N     . ALA A 1 276 ? -7.043  -6.473  -10.079 1.00 52.67  ? 285 ALA A N     1 
ATOM   2101 C  CA    . ALA A 1 276 ? -7.291  -5.193  -10.785 1.00 53.11  ? 285 ALA A CA    1 
ATOM   2102 C  C     . ALA A 1 276 ? -6.042  -4.296  -10.780 1.00 55.01  ? 285 ALA A C     1 
ATOM   2103 O  O     . ALA A 1 276 ? -5.422  -4.111  -9.716  1.00 48.87  ? 285 ALA A O     1 
ATOM   2104 C  CB    . ALA A 1 276 ? -8.460  -4.450  -10.181 1.00 45.30  ? 285 ALA A CB    1 
ATOM   2105 N  N     . LEU A 1 277 ? -5.732  -3.741  -11.957 1.00 58.05  ? 286 LEU A N     1 
ATOM   2106 C  CA    . LEU A 1 277 ? -4.674  -2.732  -12.205 1.00 60.20  ? 286 LEU A CA    1 
ATOM   2107 C  C     . LEU A 1 277 ? -5.202  -1.384  -11.715 1.00 56.05  ? 286 LEU A C     1 
ATOM   2108 O  O     . LEU A 1 277 ? -6.387  -1.251  -11.427 1.00 54.80  ? 286 LEU A O     1 
ATOM   2109 C  CB    . LEU A 1 277 ? -4.363  -2.772  -13.708 1.00 61.21  ? 286 LEU A CB    1 
ATOM   2110 C  CG    . LEU A 1 277 ? -3.868  -4.134  -14.205 1.00 66.71  ? 286 LEU A CG    1 
ATOM   2111 C  CD1   . LEU A 1 277 ? -4.108  -4.323  -15.699 1.00 69.84  ? 286 LEU A CD1   1 
ATOM   2112 C  CD2   . LEU A 1 277 ? -2.398  -4.321  -13.865 1.00 69.64  ? 286 LEU A CD2   1 
ATOM   2113 N  N     . PRO A 1 278 ? -4.365  -0.339  -11.566 1.00 61.35  ? 287 PRO A N     1 
ATOM   2114 C  CA    . PRO A 1 278 ? -4.875  0.956   -11.106 1.00 63.05  ? 287 PRO A CA    1 
ATOM   2115 C  C     . PRO A 1 278 ? -5.728  1.575   -12.216 1.00 57.24  ? 287 PRO A C     1 
ATOM   2116 O  O     . PRO A 1 278 ? -5.634  1.157   -13.368 1.00 63.26  ? 287 PRO A O     1 
ATOM   2117 C  CB    . PRO A 1 278 ? -3.600  1.747   -10.783 1.00 66.58  ? 287 PRO A CB    1 
ATOM   2118 C  CG    . PRO A 1 278 ? -2.534  1.138   -11.696 1.00 68.74  ? 287 PRO A CG    1 
ATOM   2119 C  CD    . PRO A 1 278 ? -2.924  -0.321  -11.867 1.00 68.64  ? 287 PRO A CD    1 
ATOM   2120 N  N     . PRO A 1 279 ? -6.606  2.554   -11.914 1.00 47.63  ? 288 PRO A N     1 
ATOM   2121 C  CA    . PRO A 1 279 ? -7.553  3.092   -12.894 1.00 54.91  ? 288 PRO A CA    1 
ATOM   2122 C  C     . PRO A 1 279 ? -6.951  3.862   -14.078 1.00 51.45  ? 288 PRO A C     1 
ATOM   2123 O  O     . PRO A 1 279 ? -5.911  4.474   -13.920 1.00 57.86  ? 288 PRO A O     1 
ATOM   2124 C  CB    . PRO A 1 279 ? -8.406  4.109   -12.110 1.00 51.10  ? 288 PRO A CB    1 
ATOM   2125 C  CG    . PRO A 1 279 ? -8.169  3.788   -10.656 1.00 51.10  ? 288 PRO A CG    1 
ATOM   2126 C  CD    . PRO A 1 279 ? -6.783  3.166   -10.593 1.00 53.88  ? 288 PRO A CD    1 
ATOM   2127 N  N     . LEU A 1 280 ? -7.646  3.877   -15.213 1.00 43.92  ? 289 LEU A N     1 
ATOM   2128 C  CA    . LEU A 1 280 ? -7.179  4.651   -16.390 1.00 51.94  ? 289 LEU A CA    1 
ATOM   2129 C  C     . LEU A 1 280 ? -7.992  5.934   -16.551 1.00 52.01  ? 289 LEU A C     1 
ATOM   2130 O  O     . LEU A 1 280 ? -9.108  6.089   -16.049 1.00 47.94  ? 289 LEU A O     1 
ATOM   2131 C  CB    . LEU A 1 280 ? -7.225  3.760   -17.637 1.00 56.13  ? 289 LEU A CB    1 
ATOM   2132 C  CG    . LEU A 1 280 ? -6.214  2.602   -17.651 1.00 63.68  ? 289 LEU A CG    1 
ATOM   2133 C  CD1   . LEU A 1 280 ? -6.166  1.932   -19.013 1.00 65.75  ? 289 LEU A CD1   1 
ATOM   2134 C  CD2   . LEU A 1 280 ? -4.817  3.072   -17.272 1.00 67.19  ? 289 LEU A CD2   1 
ATOM   2135 N  N     . PRO A 1 281 ? -7.447  6.912   -17.292 1.00 53.17  ? 290 PRO A N     1 
ATOM   2136 C  CA    . PRO A 1 281 ? -8.202  8.117   -17.588 1.00 52.30  ? 290 PRO A CA    1 
ATOM   2137 C  C     . PRO A 1 281 ? -9.513  7.760   -18.312 1.00 55.27  ? 290 PRO A C     1 
ATOM   2138 O  O     . PRO A 1 281 ? -9.544  6.783   -19.056 1.00 50.85  ? 290 PRO A O     1 
ATOM   2139 C  CB    . PRO A 1 281 ? -7.252  8.930   -18.487 1.00 52.59  ? 290 PRO A CB    1 
ATOM   2140 C  CG    . PRO A 1 281 ? -5.877  8.365   -18.231 1.00 52.25  ? 290 PRO A CG    1 
ATOM   2141 C  CD    . PRO A 1 281 ? -6.098  6.912   -17.878 1.00 51.44  ? 290 PRO A CD    1 
ATOM   2142 N  N     . ARG A 1 282 ? -10.550 8.565   -18.068 1.00 53.03  ? 291 ARG A N     1 
ATOM   2143 C  CA    . ARG A 1 282 ? -11.890 8.460   -18.692 1.00 53.31  ? 291 ARG A CA    1 
ATOM   2144 C  C     . ARG A 1 282 ? -12.385 9.861   -19.021 1.00 53.21  ? 291 ARG A C     1 
ATOM   2145 O  O     . ARG A 1 282 ? -11.897 10.845  -18.468 1.00 54.42  ? 291 ARG A O     1 
ATOM   2146 C  CB    . ARG A 1 282 ? -12.885 7.766   -17.766 1.00 49.37  ? 291 ARG A CB    1 
ATOM   2147 C  CG    . ARG A 1 282 ? -13.058 8.415   -16.400 1.00 52.21  ? 291 ARG A CG    1 
ATOM   2148 C  CD    . ARG A 1 282 ? -14.356 7.900   -15.807 1.00 51.69  ? 291 ARG A CD    1 
ATOM   2149 N  NE    . ARG A 1 282 ? -14.717 8.502   -14.543 1.00 60.10  ? 291 ARG A NE    1 
ATOM   2150 C  CZ    . ARG A 1 282 ? -14.442 7.996   -13.343 1.00 66.35  ? 291 ARG A CZ    1 
ATOM   2151 N  NH1   . ARG A 1 282 ? -14.819 8.639   -12.251 1.00 78.08  ? 291 ARG A NH1   1 
ATOM   2152 N  NH2   . ARG A 1 282 ? -13.791 6.860   -13.218 1.00 66.46  ? 291 ARG A NH2   1 
ATOM   2153 N  N     . PRO A 1 283 ? -13.356 10.001  -19.941 1.00 47.02  ? 292 PRO A N     1 
ATOM   2154 C  CA    . PRO A 1 283 ? -13.808 11.320  -20.357 1.00 46.23  ? 292 PRO A CA    1 
ATOM   2155 C  C     . PRO A 1 283 ? -14.439 12.085  -19.204 1.00 49.78  ? 292 PRO A C     1 
ATOM   2156 O  O     . PRO A 1 283 ? -14.941 11.502  -18.250 1.00 43.25  ? 292 PRO A O     1 
ATOM   2157 C  CB    . PRO A 1 283 ? -14.826 11.008  -21.440 1.00 42.68  ? 292 PRO A CB    1 
ATOM   2158 C  CG    . PRO A 1 283 ? -14.360 9.669   -21.959 1.00 46.96  ? 292 PRO A CG    1 
ATOM   2159 C  CD    . PRO A 1 283 ? -14.028 8.927   -20.684 1.00 52.06  ? 292 PRO A CD    1 
ATOM   2160 N  N     . PRO A 1 284 ? -14.391 13.431  -19.247 1.00 52.64  ? 293 PRO A N     1 
ATOM   2161 C  CA    . PRO A 1 284 ? -15.107 14.218  -18.254 1.00 48.02  ? 293 PRO A CA    1 
ATOM   2162 C  C     . PRO A 1 284 ? -16.628 14.090  -18.472 1.00 52.18  ? 293 PRO A C     1 
ATOM   2163 O  O     . PRO A 1 284 ? -17.112 13.792  -19.578 1.00 44.79  ? 293 PRO A O     1 
ATOM   2164 C  CB    . PRO A 1 284 ? -14.515 15.616  -18.464 1.00 49.58  ? 293 PRO A CB    1 
ATOM   2165 C  CG    . PRO A 1 284 ? -14.123 15.644  -19.939 1.00 48.64  ? 293 PRO A CG    1 
ATOM   2166 C  CD    . PRO A 1 284 ? -13.644 14.243  -20.230 1.00 45.76  ? 293 PRO A CD    1 
ATOM   2167 N  N     . THR A 1 285 ? -17.347 14.293  -17.374 1.00 51.28  ? 294 THR A N     1 
ATOM   2168 C  CA    . THR A 1 285 ? -18.809 14.102  -17.223 1.00 49.53  ? 294 THR A CA    1 
ATOM   2169 C  C     . THR A 1 285 ? -19.560 15.206  -17.955 1.00 51.34  ? 294 THR A C     1 
ATOM   2170 O  O     . THR A 1 285 ? -19.129 16.355  -17.963 1.00 49.59  ? 294 THR A O     1 
ATOM   2171 C  CB    . THR A 1 285 ? -19.173 14.133  -15.739 1.00 49.03  ? 294 THR A CB    1 
ATOM   2172 O  OG1   . THR A 1 285 ? -18.150 13.395  -15.067 1.00 49.17  ? 294 THR A OG1   1 
ATOM   2173 C  CG2   . THR A 1 285 ? -20.542 13.562  -15.449 1.00 51.66  ? 294 THR A CG2   1 
ATOM   2174 N  N     . PRO A 1 286 ? -20.689 14.900  -18.624 1.00 43.62  ? 295 PRO A N     1 
ATOM   2175 C  CA    . PRO A 1 286 ? -21.584 15.941  -19.099 1.00 42.63  ? 295 PRO A CA    1 
ATOM   2176 C  C     . PRO A 1 286 ? -22.196 16.700  -17.915 1.00 45.89  ? 295 PRO A C     1 
ATOM   2177 O  O     . PRO A 1 286 ? -22.199 16.214  -16.801 1.00 45.00  ? 295 PRO A O     1 
ATOM   2178 C  CB    . PRO A 1 286 ? -22.620 15.180  -19.946 1.00 44.12  ? 295 PRO A CB    1 
ATOM   2179 C  CG    . PRO A 1 286 ? -21.935 13.877  -20.307 1.00 43.30  ? 295 PRO A CG    1 
ATOM   2180 C  CD    . PRO A 1 286 ? -21.087 13.569  -19.092 1.00 46.50  ? 295 PRO A CD    1 
ATOM   2181 N  N     . LYS A 1 287 ? -22.629 17.919  -18.181 1.00 47.99  ? 296 LYS A N     1 
ATOM   2182 C  CA    . LYS A 1 287 ? -23.422 18.704  -17.224 1.00 56.65  ? 296 LYS A CA    1 
ATOM   2183 C  C     . LYS A 1 287 ? -24.835 18.131  -17.218 1.00 60.29  ? 296 LYS A C     1 
ATOM   2184 O  O     . LYS A 1 287 ? -25.461 18.134  -18.300 1.00 64.21  ? 296 LYS A O     1 
ATOM   2185 C  CB    . LYS A 1 287 ? -23.498 20.168  -17.647 1.00 55.40  ? 296 LYS A CB    1 
ATOM   2186 C  CG    . LYS A 1 287 ? -22.207 20.957  -17.533 1.00 57.50  ? 296 LYS A CG    1 
ATOM   2187 C  CD    . LYS A 1 287 ? -22.360 22.249  -18.299 1.00 62.11  ? 296 LYS A CD    1 
ATOM   2188 C  CE    . LYS A 1 287 ? -21.374 23.322  -17.920 1.00 61.14  ? 296 LYS A CE    1 
ATOM   2189 N  NZ    . LYS A 1 287 ? -21.675 24.592  -18.621 1.00 61.72  ? 296 LYS A NZ    1 
ATOM   2190 N  N     . LEU A 1 288 ? -25.335 17.727  -16.047 1.00 60.69  ? 297 LEU A N     1 
ATOM   2191 C  CA    . LEU A 1 288 ? -26.714 17.188  -15.885 1.00 68.97  ? 297 LEU A CA    1 
ATOM   2192 C  C     . LEU A 1 288 ? -27.587 18.151  -15.046 1.00 69.25  ? 297 LEU A C     1 
ATOM   2193 O  O     . LEU A 1 288 ? -27.276 18.355  -13.843 1.00 80.35  ? 297 LEU A O     1 
ATOM   2194 C  CB    . LEU A 1 288 ? -26.572 15.791  -15.265 1.00 80.46  ? 297 LEU A CB    1 
ATOM   2195 C  CG    . LEU A 1 288 ? -25.386 14.955  -15.775 1.00 81.45  ? 297 LEU A CG    1 
ATOM   2196 C  CD1   . LEU A 1 288 ? -25.145 13.741  -14.889 1.00 83.58  ? 297 LEU A CD1   1 
ATOM   2197 C  CD2   . LEU A 1 288 ? -25.574 14.525  -17.228 1.00 74.45  ? 297 LEU A CD2   1 
ATOM   2198 N  N     . GLU A 1 289 ? -28.628 18.734  -15.662 1.00 67.00  ? 298 GLU A N     1 
ATOM   2199 C  CA    . GLU A 1 289 ? -29.747 19.501  -15.014 1.00 82.64  ? 298 GLU A CA    1 
ATOM   2200 C  C     . GLU A 1 289 ? -29.206 20.617  -14.109 1.00 82.59  ? 298 GLU A C     1 
ATOM   2201 O  O     . GLU A 1 289 ? -28.633 21.599  -14.587 1.00 87.56  ? 298 GLU A O     1 
ATOM   2202 C  CB    . GLU A 1 289 ? -30.676 18.605  -14.183 1.00 80.49  ? 298 GLU A CB    1 
ATOM   2203 C  CG    . GLU A 1 289 ? -31.769 19.380  -13.444 1.00 79.40  ? 298 GLU A CG    1 
ATOM   2204 C  CD    . GLU A 1 289 ? -32.870 18.554  -12.783 1.00 77.13  ? 298 GLU A CD    1 
ATOM   2205 O  OE1   . GLU A 1 289 ? -33.421 19.018  -11.772 1.00 78.62  ? 298 GLU A OE1   1 
ATOM   2206 O  OE2   . GLU A 1 289 ? -33.196 17.457  -13.276 1.00 73.33  ? 298 GLU A OE2   1 
ATOM   2207 N  N     . ALA B 1 4   ? -41.580 -23.402 -51.883 1.00 106.31 ? 13  ALA B N     1 
ATOM   2208 C  CA    . ALA B 1 4   ? -40.246 -23.544 -52.535 1.00 101.10 ? 13  ALA B CA    1 
ATOM   2209 C  C     . ALA B 1 4   ? -39.596 -24.873 -52.121 1.00 101.09 ? 13  ALA B C     1 
ATOM   2210 O  O     . ALA B 1 4   ? -39.774 -25.295 -50.961 1.00 99.72  ? 13  ALA B O     1 
ATOM   2211 C  CB    . ALA B 1 4   ? -39.374 -22.359 -52.185 1.00 94.61  ? 13  ALA B CB    1 
ATOM   2212 N  N     . ASP B 1 5   ? -38.889 -25.507 -53.061 1.00 101.68 ? 14  ASP B N     1 
ATOM   2213 C  CA    . ASP B 1 5   ? -38.022 -26.697 -52.840 1.00 105.24 ? 14  ASP B CA    1 
ATOM   2214 C  C     . ASP B 1 5   ? -36.857 -26.258 -51.931 1.00 109.32 ? 14  ASP B C     1 
ATOM   2215 O  O     . ASP B 1 5   ? -36.001 -25.481 -52.423 1.00 117.64 ? 14  ASP B O     1 
ATOM   2216 C  CB    . ASP B 1 5   ? -37.586 -27.247 -54.207 1.00 103.31 ? 14  ASP B CB    1 
ATOM   2217 C  CG    . ASP B 1 5   ? -37.268 -28.733 -54.274 1.00 104.42 ? 14  ASP B CG    1 
ATOM   2218 O  OD1   . ASP B 1 5   ? -37.383 -29.416 -53.237 1.00 103.60 ? 14  ASP B OD1   1 
ATOM   2219 O  OD2   . ASP B 1 5   ? -36.909 -29.200 -55.382 1.00 95.26  ? 14  ASP B OD2   1 
ATOM   2220 N  N     . LYS B 1 6   ? -36.832 -26.701 -50.659 1.00 98.22  ? 15  LYS B N     1 
ATOM   2221 C  CA    . LYS B 1 6   ? -35.904 -26.196 -49.595 1.00 87.52  ? 15  LYS B CA    1 
ATOM   2222 C  C     . LYS B 1 6   ? -34.856 -27.250 -49.180 1.00 89.30  ? 15  LYS B C     1 
ATOM   2223 O  O     . LYS B 1 6   ? -34.139 -26.990 -48.196 1.00 83.86  ? 15  LYS B O     1 
ATOM   2224 C  CB    . LYS B 1 6   ? -36.701 -25.743 -48.363 1.00 82.09  ? 15  LYS B CB    1 
ATOM   2225 C  CG    . LYS B 1 6   ? -37.156 -24.289 -48.367 1.00 81.56  ? 15  LYS B CG    1 
ATOM   2226 C  CD    . LYS B 1 6   ? -38.205 -23.972 -47.316 1.00 83.14  ? 15  LYS B CD    1 
ATOM   2227 C  CE    . LYS B 1 6   ? -38.801 -22.585 -47.466 1.00 80.61  ? 15  LYS B CE    1 
ATOM   2228 N  NZ    . LYS B 1 6   ? -40.037 -22.418 -46.658 1.00 76.11  ? 15  LYS B NZ    1 
ATOM   2229 N  N     . GLY B 1 7   ? -34.768 -28.394 -49.870 1.00 92.97  ? 16  GLY B N     1 
ATOM   2230 C  CA    . GLY B 1 7   ? -33.706 -29.406 -49.666 1.00 87.50  ? 16  GLY B CA    1 
ATOM   2231 C  C     . GLY B 1 7   ? -33.776 -30.091 -48.308 1.00 81.57  ? 16  GLY B C     1 
ATOM   2232 O  O     . GLY B 1 7   ? -34.626 -29.715 -47.494 1.00 73.24  ? 16  GLY B O     1 
ATOM   2233 N  N     . LYS B 1 8   ? -32.889 -31.066 -48.076 1.00 87.91  ? 17  LYS B N     1 
ATOM   2234 C  CA    . LYS B 1 8   ? -32.783 -31.872 -46.822 1.00 81.18  ? 17  LYS B CA    1 
ATOM   2235 C  C     . LYS B 1 8   ? -32.446 -30.965 -45.631 1.00 77.16  ? 17  LYS B C     1 
ATOM   2236 O  O     . LYS B 1 8   ? -31.440 -30.229 -45.721 1.00 79.81  ? 17  LYS B O     1 
ATOM   2237 C  CB    . LYS B 1 8   ? -31.683 -32.929 -46.950 1.00 87.78  ? 17  LYS B CB    1 
ATOM   2238 C  CG    . LYS B 1 8   ? -32.077 -34.236 -47.625 1.00 87.65  ? 17  LYS B CG    1 
ATOM   2239 C  CD    . LYS B 1 8   ? -31.249 -35.415 -47.149 1.00 90.32  ? 17  LYS B CD    1 
ATOM   2240 C  CE    . LYS B 1 8   ? -31.428 -36.656 -47.999 1.00 102.20 ? 17  LYS B CE    1 
ATOM   2241 N  NZ    . LYS B 1 8   ? -32.861 -36.983 -48.206 1.00 101.41 ? 17  LYS B NZ    1 
ATOM   2242 N  N     . CYS B 1 9   ? -33.243 -31.026 -44.559 1.00 67.40  ? 18  CYS B N     1 
ATOM   2243 C  CA    . CYS B 1 9   ? -33.157 -30.119 -43.379 1.00 69.60  ? 18  CYS B CA    1 
ATOM   2244 C  C     . CYS B 1 9   ? -33.028 -30.953 -42.109 1.00 68.27  ? 18  CYS B C     1 
ATOM   2245 O  O     . CYS B 1 9   ? -33.803 -31.911 -41.978 1.00 77.68  ? 18  CYS B O     1 
ATOM   2246 C  CB    . CYS B 1 9   ? -34.393 -29.235 -43.233 1.00 69.18  ? 18  CYS B CB    1 
ATOM   2247 S  SG    . CYS B 1 9   ? -34.687 -28.088 -44.610 1.00 76.01  ? 18  CYS B SG    1 
ATOM   2248 N  N     . GLY B 1 10  ? -32.102 -30.596 -41.212 1.00 63.36  ? 19  GLY B N     1 
ATOM   2249 C  CA    . GLY B 1 10  ? -32.054 -31.118 -39.823 1.00 61.61  ? 19  GLY B CA    1 
ATOM   2250 C  C     . GLY B 1 10  ? -31.279 -32.425 -39.641 1.00 59.16  ? 19  GLY B C     1 
ATOM   2251 O  O     . GLY B 1 10  ? -31.441 -33.045 -38.578 1.00 59.17  ? 19  GLY B O     1 
ATOM   2252 N  N     . LEU B 1 11  ? -30.448 -32.827 -40.607 1.00 55.92  ? 20  LEU B N     1 
ATOM   2253 C  CA    . LEU B 1 11  ? -29.577 -34.027 -40.508 1.00 63.33  ? 20  LEU B CA    1 
ATOM   2254 C  C     . LEU B 1 11  ? -28.917 -34.032 -39.126 1.00 61.56  ? 20  LEU B C     1 
ATOM   2255 O  O     . LEU B 1 11  ? -28.708 -32.979 -38.532 1.00 55.20  ? 20  LEU B O     1 
ATOM   2256 C  CB    . LEU B 1 11  ? -28.538 -33.991 -41.640 1.00 64.87  ? 20  LEU B CB    1 
ATOM   2257 C  CG    . LEU B 1 11  ? -28.937 -34.646 -42.968 1.00 69.91  ? 20  LEU B CG    1 
ATOM   2258 C  CD1   . LEU B 1 11  ? -30.351 -34.283 -43.398 1.00 67.69  ? 20  LEU B CD1   1 
ATOM   2259 C  CD2   . LEU B 1 11  ? -27.950 -34.283 -44.075 1.00 71.66  ? 20  LEU B CD2   1 
ATOM   2260 N  N     . PRO B 1 12  ? -28.595 -35.203 -38.528 1.00 58.41  ? 21  PRO B N     1 
ATOM   2261 C  CA    . PRO B 1 12  ? -27.840 -35.206 -37.278 1.00 54.74  ? 21  PRO B CA    1 
ATOM   2262 C  C     . PRO B 1 12  ? -26.491 -34.549 -37.578 1.00 54.82  ? 21  PRO B C     1 
ATOM   2263 O  O     . PRO B 1 12  ? -26.119 -34.571 -38.738 1.00 56.50  ? 21  PRO B O     1 
ATOM   2264 C  CB    . PRO B 1 12  ? -27.724 -36.691 -36.893 1.00 56.18  ? 21  PRO B CB    1 
ATOM   2265 C  CG    . PRO B 1 12  ? -28.755 -37.409 -37.733 1.00 55.67  ? 21  PRO B CG    1 
ATOM   2266 C  CD    . PRO B 1 12  ? -28.940 -36.561 -38.981 1.00 58.23  ? 21  PRO B CD    1 
ATOM   2267 N  N     . GLU B 1 13  ? -25.801 -34.013 -36.565 1.00 53.38  ? 22  GLU B N     1 
ATOM   2268 C  CA    . GLU B 1 13  ? -24.417 -33.487 -36.716 1.00 54.70  ? 22  GLU B CA    1 
ATOM   2269 C  C     . GLU B 1 13  ? -23.389 -34.568 -36.387 1.00 54.41  ? 22  GLU B C     1 
ATOM   2270 O  O     . GLU B 1 13  ? -23.690 -35.481 -35.623 1.00 52.71  ? 22  GLU B O     1 
ATOM   2271 C  CB    . GLU B 1 13  ? -24.125 -32.312 -35.793 1.00 58.12  ? 22  GLU B CB    1 
ATOM   2272 C  CG    . GLU B 1 13  ? -25.267 -31.328 -35.679 1.00 63.73  ? 22  GLU B CG    1 
ATOM   2273 C  CD    . GLU B 1 13  ? -25.099 -30.383 -34.510 1.00 65.53  ? 22  GLU B CD    1 
ATOM   2274 O  OE1   . GLU B 1 13  ? -24.979 -30.867 -33.335 1.00 67.63  ? 22  GLU B OE1   1 
ATOM   2275 O  OE2   . GLU B 1 13  ? -25.054 -29.185 -34.778 1.00 60.06  ? 22  GLU B OE2   1 
ATOM   2276 N  N     . ILE B 1 14  ? -22.183 -34.383 -36.904 1.00 58.58  ? 23  ILE B N     1 
ATOM   2277 C  CA    . ILE B 1 14  ? -21.005 -35.264 -36.709 1.00 60.59  ? 23  ILE B CA    1 
ATOM   2278 C  C     . ILE B 1 14  ? -19.980 -34.482 -35.893 1.00 59.00  ? 23  ILE B C     1 
ATOM   2279 O  O     . ILE B 1 14  ? -19.726 -33.330 -36.254 1.00 60.80  ? 23  ILE B O     1 
ATOM   2280 C  CB    . ILE B 1 14  ? -20.425 -35.686 -38.075 1.00 64.31  ? 23  ILE B CB    1 
ATOM   2281 C  CG1   . ILE B 1 14  ? -21.482 -36.325 -38.984 1.00 72.63  ? 23  ILE B CG1   1 
ATOM   2282 C  CG2   . ILE B 1 14  ? -19.217 -36.593 -37.876 1.00 67.72  ? 23  ILE B CG2   1 
ATOM   2283 C  CD1   . ILE B 1 14  ? -21.266 -36.062 -40.464 1.00 79.62  ? 23  ILE B CD1   1 
ATOM   2284 N  N     . PHE B 1 15  ? -19.386 -35.105 -34.878 1.00 54.34  ? 24  PHE B N     1 
ATOM   2285 C  CA    . PHE B 1 15  ? -18.270 -34.531 -34.090 1.00 59.49  ? 24  PHE B CA    1 
ATOM   2286 C  C     . PHE B 1 15  ? -17.058 -35.475 -34.147 1.00 70.08  ? 24  PHE B C     1 
ATOM   2287 O  O     . PHE B 1 15  ? -17.000 -36.440 -33.348 1.00 70.00  ? 24  PHE B O     1 
ATOM   2288 C  CB    . PHE B 1 15  ? -18.742 -34.220 -32.672 1.00 53.81  ? 24  PHE B CB    1 
ATOM   2289 C  CG    . PHE B 1 15  ? -19.849 -33.191 -32.593 1.00 61.34  ? 24  PHE B CG    1 
ATOM   2290 C  CD1   . PHE B 1 15  ? -19.564 -31.836 -32.563 1.00 54.99  ? 24  PHE B CD1   1 
ATOM   2291 C  CD2   . PHE B 1 15  ? -21.185 -33.574 -32.548 1.00 66.20  ? 24  PHE B CD2   1 
ATOM   2292 C  CE1   . PHE B 1 15  ? -20.580 -30.894 -32.491 1.00 59.62  ? 24  PHE B CE1   1 
ATOM   2293 C  CE2   . PHE B 1 15  ? -22.203 -32.626 -32.475 1.00 64.01  ? 24  PHE B CE2   1 
ATOM   2294 C  CZ    . PHE B 1 15  ? -21.899 -31.287 -32.451 1.00 57.87  ? 24  PHE B CZ    1 
ATOM   2295 N  N     . ASP B 1 16  ? -16.119 -35.184 -35.062 1.00 63.73  ? 25  ASP B N     1 
ATOM   2296 C  CA    . ASP B 1 16  ? -14.763 -35.793 -35.126 1.00 64.54  ? 25  ASP B CA    1 
ATOM   2297 C  C     . ASP B 1 16  ? -14.140 -35.772 -33.727 1.00 65.89  ? 25  ASP B C     1 
ATOM   2298 O  O     . ASP B 1 16  ? -14.151 -34.734 -33.082 1.00 63.80  ? 25  ASP B O     1 
ATOM   2299 C  CB    . ASP B 1 16  ? -13.882 -35.079 -36.164 1.00 67.98  ? 25  ASP B CB    1 
ATOM   2300 C  CG    . ASP B 1 16  ? -14.210 -35.386 -37.633 1.00 74.35  ? 25  ASP B CG    1 
ATOM   2301 O  OD1   . ASP B 1 16  ? -15.072 -36.276 -37.898 1.00 61.55  ? 25  ASP B OD1   1 
ATOM   2302 O  OD2   . ASP B 1 16  ? -13.611 -34.722 -38.529 1.00 63.19  ? 25  ASP B OD2   1 
ATOM   2303 N  N     . PRO B 1 17  ? -13.624 -36.910 -33.192 1.00 65.03  ? 26  PRO B N     1 
ATOM   2304 C  CA    . PRO B 1 17  ? -12.828 -36.909 -31.961 1.00 71.87  ? 26  PRO B CA    1 
ATOM   2305 C  C     . PRO B 1 17  ? -11.557 -36.062 -32.030 1.00 68.91  ? 26  PRO B C     1 
ATOM   2306 O  O     . PRO B 1 17  ? -10.968 -35.929 -33.107 1.00 74.39  ? 26  PRO B O     1 
ATOM   2307 C  CB    . PRO B 1 17  ? -12.443 -38.388 -31.748 1.00 72.22  ? 26  PRO B CB    1 
ATOM   2308 C  CG    . PRO B 1 17  ? -12.656 -39.037 -33.097 1.00 69.70  ? 26  PRO B CG    1 
ATOM   2309 C  CD    . PRO B 1 17  ? -13.803 -38.270 -33.722 1.00 70.52  ? 26  PRO B CD    1 
ATOM   2310 N  N     . PRO B 1 18  ? -11.073 -35.533 -30.875 1.00 61.56  ? 27  PRO B N     1 
ATOM   2311 C  CA    . PRO B 1 18  ? -10.016 -34.510 -30.839 1.00 65.56  ? 27  PRO B CA    1 
ATOM   2312 C  C     . PRO B 1 18  ? -8.715  -34.910 -31.553 1.00 65.16  ? 27  PRO B C     1 
ATOM   2313 O  O     . PRO B 1 18  ? -8.208  -34.123 -32.355 1.00 62.36  ? 27  PRO B O     1 
ATOM   2314 C  CB    . PRO B 1 18  ? -9.703  -34.326 -29.338 1.00 59.75  ? 27  PRO B CB    1 
ATOM   2315 C  CG    . PRO B 1 18  ? -10.955 -34.807 -28.640 1.00 60.27  ? 27  PRO B CG    1 
ATOM   2316 C  CD    . PRO B 1 18  ? -11.469 -35.939 -29.514 1.00 63.50  ? 27  PRO B CD    1 
ATOM   2317 N  N     . GLU B 1 19  ? -8.221  -36.114 -31.249 1.00 66.68  ? 28  GLU B N     1 
ATOM   2318 C  CA    . GLU B 1 19  ? -7.013  -36.709 -31.884 1.00 73.10  ? 28  GLU B CA    1 
ATOM   2319 C  C     . GLU B 1 19  ? -7.156  -36.597 -33.405 1.00 62.38  ? 28  GLU B C     1 
ATOM   2320 O  O     . GLU B 1 19  ? -6.287  -35.975 -34.042 1.00 47.93  ? 28  GLU B O     1 
ATOM   2321 C  CB    . GLU B 1 19  ? -6.820  -38.152 -31.410 1.00 76.29  ? 28  GLU B CB    1 
ATOM   2322 C  CG    . GLU B 1 19  ? -6.381  -38.240 -29.952 1.00 81.38  ? 28  GLU B CG    1 
ATOM   2323 C  CD    . GLU B 1 19  ? -5.825  -39.585 -29.502 1.00 86.74  ? 28  GLU B CD    1 
ATOM   2324 O  OE1   . GLU B 1 19  ? -6.522  -40.604 -29.662 1.00 89.30  ? 28  GLU B OE1   1 
ATOM   2325 O  OE2   . GLU B 1 19  ? -4.700  -39.609 -28.976 1.00 86.90  ? 28  GLU B OE2   1 
ATOM   2326 N  N     . GLU B 1 20  ? -8.263  -37.120 -33.931 1.00 64.21  ? 29  GLU B N     1 
ATOM   2327 C  CA    . GLU B 1 20  ? -8.600  -37.126 -35.379 1.00 68.25  ? 29  GLU B CA    1 
ATOM   2328 C  C     . GLU B 1 20  ? -8.757  -35.683 -35.883 1.00 68.48  ? 29  GLU B C     1 
ATOM   2329 O  O     . GLU B 1 20  ? -8.283  -35.387 -36.998 1.00 57.03  ? 29  GLU B O     1 
ATOM   2330 C  CB    . GLU B 1 20  ? -9.854  -37.974 -35.584 1.00 72.10  ? 29  GLU B CB    1 
ATOM   2331 C  CG    . GLU B 1 20  ? -10.434 -37.912 -36.982 1.00 70.20  ? 29  GLU B CG    1 
ATOM   2332 C  CD    . GLU B 1 20  ? -11.340 -39.084 -37.318 1.00 74.60  ? 29  GLU B CD    1 
ATOM   2333 O  OE1   . GLU B 1 20  ? -11.248 -40.108 -36.621 1.00 80.51  ? 29  GLU B OE1   1 
ATOM   2334 O  OE2   . GLU B 1 20  ? -12.134 -38.977 -38.284 1.00 81.13  ? 29  GLU B OE2   1 
ATOM   2335 N  N     . LEU B 1 21  ? -9.370  -34.806 -35.085 1.00 70.90  ? 30  LEU B N     1 
ATOM   2336 C  CA    . LEU B 1 21  ? -9.645  -33.394 -35.479 1.00 66.08  ? 30  LEU B CA    1 
ATOM   2337 C  C     . LEU B 1 21  ? -8.322  -32.631 -35.680 1.00 57.20  ? 30  LEU B C     1 
ATOM   2338 O  O     . LEU B 1 21  ? -8.165  -31.961 -36.734 1.00 50.76  ? 30  LEU B O     1 
ATOM   2339 C  CB    . LEU B 1 21  ? -10.535 -32.756 -34.405 1.00 63.20  ? 30  LEU B CB    1 
ATOM   2340 C  CG    . LEU B 1 21  ? -11.071 -31.354 -34.698 1.00 62.19  ? 30  LEU B CG    1 
ATOM   2341 C  CD1   . LEU B 1 21  ? -11.550 -31.209 -36.142 1.00 65.87  ? 30  LEU B CD1   1 
ATOM   2342 C  CD2   . LEU B 1 21  ? -12.203 -31.027 -33.739 1.00 63.04  ? 30  LEU B CD2   1 
ATOM   2343 N  N     . GLU B 1 22  ? -7.397  -32.742 -34.729 1.00 64.08  ? 31  GLU B N     1 
ATOM   2344 C  CA    . GLU B 1 22  ? -6.021  -32.177 -34.849 1.00 67.77  ? 31  GLU B CA    1 
ATOM   2345 C  C     . GLU B 1 22  ? -5.312  -32.819 -36.048 1.00 61.57  ? 31  GLU B C     1 
ATOM   2346 O  O     . GLU B 1 22  ? -4.709  -32.064 -36.813 1.00 61.89  ? 31  GLU B O     1 
ATOM   2347 C  CB    . GLU B 1 22  ? -5.204  -32.281 -33.547 1.00 64.99  ? 31  GLU B CB    1 
ATOM   2348 C  CG    . GLU B 1 22  ? -5.226  -30.993 -32.698 1.00 77.81  ? 31  GLU B CG    1 
ATOM   2349 C  CD    . GLU B 1 22  ? -4.645  -29.689 -33.279 1.00 84.60  ? 31  GLU B CD    1 
ATOM   2350 O  OE1   . GLU B 1 22  ? -3.884  -28.977 -32.544 1.00 71.14  ? 31  GLU B OE1   1 
ATOM   2351 O  OE2   . GLU B 1 22  ? -4.980  -29.333 -34.448 1.00 85.04  ? 31  GLU B OE2   1 
ATOM   2352 N  N     . ARG B 1 23  ? -5.397  -34.138 -36.253 1.00 62.91  ? 32  ARG B N     1 
ATOM   2353 C  CA    . ARG B 1 23  ? -4.771  -34.769 -37.452 1.00 63.97  ? 32  ARG B CA    1 
ATOM   2354 C  C     . ARG B 1 23  ? -5.267  -34.032 -38.717 1.00 60.43  ? 32  ARG B C     1 
ATOM   2355 O  O     . ARG B 1 23  ? -4.400  -33.634 -39.518 1.00 62.83  ? 32  ARG B O     1 
ATOM   2356 C  CB    . ARG B 1 23  ? -4.983  -36.287 -37.463 1.00 65.97  ? 32  ARG B CB    1 
ATOM   2357 C  CG    . ARG B 1 23  ? -4.540  -36.978 -38.748 1.00 72.00  ? 32  ARG B CG    1 
ATOM   2358 C  CD    . ARG B 1 23  ? -4.604  -38.508 -38.711 1.00 80.77  ? 32  ARG B CD    1 
ATOM   2359 N  NE    . ARG B 1 23  ? -5.887  -39.117 -38.324 1.00 79.49  ? 32  ARG B NE    1 
ATOM   2360 C  CZ    . ARG B 1 23  ? -6.991  -39.208 -39.087 1.00 77.74  ? 32  ARG B CZ    1 
ATOM   2361 N  NH1   . ARG B 1 23  ? -7.038  -38.713 -40.317 1.00 74.33  ? 32  ARG B NH1   1 
ATOM   2362 N  NH2   . ARG B 1 23  ? -8.075  -39.773 -38.587 1.00 77.56  ? 32  ARG B NH2   1 
ATOM   2363 N  N     . LYS B 1 24  ? -6.575  -33.775 -38.859 1.00 53.90  ? 33  LYS B N     1 
ATOM   2364 C  CA    . LYS B 1 24  ? -7.214  -33.211 -40.096 1.00 55.69  ? 33  LYS B CA    1 
ATOM   2365 C  C     . LYS B 1 24  ? -6.837  -31.741 -40.318 1.00 52.75  ? 33  LYS B C     1 
ATOM   2366 O  O     . LYS B 1 24  ? -6.617  -31.336 -41.484 1.00 55.25  ? 33  LYS B O     1 
ATOM   2367 C  CB    . LYS B 1 24  ? -8.737  -33.381 -40.053 1.00 53.92  ? 33  LYS B CB    1 
ATOM   2368 C  CG    . LYS B 1 24  ? -9.182  -34.837 -40.225 1.00 58.94  ? 33  LYS B CG    1 
ATOM   2369 C  CD    . LYS B 1 24  ? -10.643 -35.137 -39.919 1.00 61.70  ? 33  LYS B CD    1 
ATOM   2370 C  CE    . LYS B 1 24  ? -11.091 -36.505 -40.410 1.00 59.57  ? 33  LYS B CE    1 
ATOM   2371 N  NZ    . LYS B 1 24  ? -12.567 -36.590 -40.590 1.00 54.44  ? 33  LYS B NZ    1 
ATOM   2372 N  N     . VAL B 1 25  ? -6.745  -30.957 -39.256 1.00 53.59  ? 34  VAL B N     1 
ATOM   2373 C  CA    . VAL B 1 25  ? -6.395  -29.516 -39.383 1.00 54.30  ? 34  VAL B CA    1 
ATOM   2374 C  C     . VAL B 1 25  ? -4.927  -29.413 -39.787 1.00 54.07  ? 34  VAL B C     1 
ATOM   2375 O  O     . VAL B 1 25  ? -4.613  -28.423 -40.504 1.00 51.07  ? 34  VAL B O     1 
ATOM   2376 C  CB    . VAL B 1 25  ? -6.701  -28.707 -38.113 1.00 56.52  ? 34  VAL B CB    1 
ATOM   2377 C  CG1   . VAL B 1 25  ? -6.106  -27.315 -38.190 1.00 58.52  ? 34  VAL B CG1   1 
ATOM   2378 C  CG2   . VAL B 1 25  ? -8.205  -28.630 -37.861 1.00 59.78  ? 34  VAL B CG2   1 
ATOM   2379 N  N     . TRP B 1 26  ? -4.074  -30.370 -39.379 1.00 50.82  ? 35  TRP B N     1 
ATOM   2380 C  CA    . TRP B 1 26  ? -2.665  -30.445 -39.868 1.00 57.16  ? 35  TRP B CA    1 
ATOM   2381 C  C     . TRP B 1 26  ? -2.704  -30.834 -41.355 1.00 58.15  ? 35  TRP B C     1 
ATOM   2382 O  O     . TRP B 1 26  ? -1.908  -30.316 -42.130 1.00 51.63  ? 35  TRP B O     1 
ATOM   2383 C  CB    . TRP B 1 26  ? -1.774  -31.394 -39.052 1.00 56.14  ? 35  TRP B CB    1 
ATOM   2384 C  CG    . TRP B 1 26  ? -1.154  -30.821 -37.811 1.00 70.62  ? 35  TRP B CG    1 
ATOM   2385 C  CD1   . TRP B 1 26  ? -1.430  -31.182 -36.519 1.00 76.20  ? 35  TRP B CD1   1 
ATOM   2386 C  CD2   . TRP B 1 26  ? -0.100  -29.838 -37.724 1.00 76.26  ? 35  TRP B CD2   1 
ATOM   2387 N  NE1   . TRP B 1 26  ? -0.645  -30.479 -35.641 1.00 72.86  ? 35  TRP B NE1   1 
ATOM   2388 C  CE2   . TRP B 1 26  ? 0.181   -29.649 -36.350 1.00 75.42  ? 35  TRP B CE2   1 
ATOM   2389 C  CE3   . TRP B 1 26  ? 0.628   -29.097 -38.664 1.00 77.24  ? 35  TRP B CE3   1 
ATOM   2390 C  CZ2   . TRP B 1 26  ? 1.147   -28.747 -35.901 1.00 82.42  ? 35  TRP B CZ2   1 
ATOM   2391 C  CZ3   . TRP B 1 26  ? 1.577   -28.203 -38.219 1.00 82.78  ? 35  TRP B CZ3   1 
ATOM   2392 C  CH2   . TRP B 1 26  ? 1.831   -28.030 -36.856 1.00 85.35  ? 35  TRP B CH2   1 
ATOM   2393 N  N     . GLU B 1 27  ? -3.609  -31.722 -41.751 1.00 62.33  ? 36  GLU B N     1 
ATOM   2394 C  CA    . GLU B 1 27  ? -3.758  -32.068 -43.183 1.00 71.88  ? 36  GLU B CA    1 
ATOM   2395 C  C     . GLU B 1 27  ? -4.133  -30.790 -43.954 1.00 68.55  ? 36  GLU B C     1 
ATOM   2396 O  O     . GLU B 1 27  ? -3.446  -30.469 -44.952 1.00 59.14  ? 36  GLU B O     1 
ATOM   2397 C  CB    . GLU B 1 27  ? -4.756  -33.210 -43.375 1.00 73.85  ? 36  GLU B CB    1 
ATOM   2398 C  CG    . GLU B 1 27  ? -4.740  -33.767 -44.785 1.00 84.09  ? 36  GLU B CG    1 
ATOM   2399 C  CD    . GLU B 1 27  ? -3.361  -33.853 -45.422 1.00 83.16  ? 36  GLU B CD    1 
ATOM   2400 O  OE1   . GLU B 1 27  ? -2.414  -34.291 -44.737 1.00 88.16  ? 36  GLU B OE1   1 
ATOM   2401 O  OE2   . GLU B 1 27  ? -3.239  -33.474 -46.600 1.00 87.99  ? 36  GLU B OE2   1 
ATOM   2402 N  N     . LEU B 1 28  ? -5.172  -30.081 -43.507 1.00 59.47  ? 37  LEU B N     1 
ATOM   2403 C  CA    . LEU B 1 28  ? -5.639  -28.821 -44.143 1.00 52.86  ? 37  LEU B CA    1 
ATOM   2404 C  C     . LEU B 1 28  ? -4.464  -27.848 -44.302 1.00 55.56  ? 37  LEU B C     1 
ATOM   2405 O  O     . LEU B 1 28  ? -4.251  -27.316 -45.410 1.00 52.89  ? 37  LEU B O     1 
ATOM   2406 C  CB    . LEU B 1 28  ? -6.718  -28.219 -43.247 1.00 46.92  ? 37  LEU B CB    1 
ATOM   2407 C  CG    . LEU B 1 28  ? -7.281  -26.881 -43.693 1.00 46.50  ? 37  LEU B CG    1 
ATOM   2408 C  CD1   . LEU B 1 28  ? -7.582  -26.864 -45.195 1.00 48.21  ? 37  LEU B CD1   1 
ATOM   2409 C  CD2   . LEU B 1 28  ? -8.513  -26.549 -42.869 1.00 43.34  ? 37  LEU B CD2   1 
ATOM   2410 N  N     . ALA B 1 29  ? -3.727  -27.612 -43.221 1.00 56.70  ? 38  ALA B N     1 
ATOM   2411 C  CA    . ALA B 1 29  ? -2.594  -26.662 -43.189 1.00 56.08  ? 38  ALA B CA    1 
ATOM   2412 C  C     . ALA B 1 29  ? -1.588  -27.049 -44.283 1.00 52.36  ? 38  ALA B C     1 
ATOM   2413 O  O     . ALA B 1 29  ? -1.238  -26.185 -45.091 1.00 54.57  ? 38  ALA B O     1 
ATOM   2414 C  CB    . ALA B 1 29  ? -1.981  -26.652 -41.810 1.00 60.03  ? 38  ALA B CB    1 
ATOM   2415 N  N     . ARG B 1 30  ? -1.178  -28.317 -44.332 1.00 53.29  ? 39  ARG B N     1 
ATOM   2416 C  CA    . ARG B 1 30  ? -0.310  -28.883 -45.412 1.00 61.57  ? 39  ARG B CA    1 
ATOM   2417 C  C     . ARG B 1 30  ? -0.863  -28.455 -46.781 1.00 55.94  ? 39  ARG B C     1 
ATOM   2418 O  O     . ARG B 1 30  ? -0.105  -27.924 -47.569 1.00 66.16  ? 39  ARG B O     1 
ATOM   2419 C  CB    . ARG B 1 30  ? -0.164  -30.403 -45.269 1.00 67.07  ? 39  ARG B CB    1 
ATOM   2420 C  CG    . ARG B 1 30  ? 0.921   -31.016 -46.148 1.00 76.93  ? 39  ARG B CG    1 
ATOM   2421 C  CD    . ARG B 1 30  ? 1.305   -32.466 -45.851 1.00 73.63  ? 39  ARG B CD    1 
ATOM   2422 N  NE    . ARG B 1 30  ? 0.254   -33.434 -46.155 1.00 79.82  ? 39  ARG B NE    1 
ATOM   2423 C  CZ    . ARG B 1 30  ? -0.049  -33.904 -47.370 1.00 91.96  ? 39  ARG B CZ    1 
ATOM   2424 N  NH1   . ARG B 1 30  ? 0.613   -33.494 -48.440 1.00 92.63  ? 39  ARG B NH1   1 
ATOM   2425 N  NH2   . ARG B 1 30  ? -1.022  -34.793 -47.512 1.00 91.65  ? 39  ARG B NH2   1 
ATOM   2426 N  N     . LEU B 1 31  ? -2.162  -28.599 -47.014 1.00 59.39  ? 40  LEU B N     1 
ATOM   2427 C  CA    . LEU B 1 31  ? -2.794  -28.306 -48.324 1.00 60.64  ? 40  LEU B CA    1 
ATOM   2428 C  C     . LEU B 1 31  ? -2.761  -26.799 -48.607 1.00 62.02  ? 40  LEU B C     1 
ATOM   2429 O  O     . LEU B 1 31  ? -2.533  -26.424 -49.791 1.00 57.18  ? 40  LEU B O     1 
ATOM   2430 C  CB    . LEU B 1 31  ? -4.221  -28.864 -48.329 1.00 56.83  ? 40  LEU B CB    1 
ATOM   2431 C  CG    . LEU B 1 31  ? -4.329  -30.377 -48.145 1.00 56.25  ? 40  LEU B CG    1 
ATOM   2432 C  CD1   . LEU B 1 31  ? -5.780  -30.814 -48.200 1.00 59.86  ? 40  LEU B CD1   1 
ATOM   2433 C  CD2   . LEU B 1 31  ? -3.507  -31.139 -49.174 1.00 57.84  ? 40  LEU B CD2   1 
ATOM   2434 N  N     . VAL B 1 32  ? -2.990  -25.960 -47.594 1.00 58.70  ? 41  VAL B N     1 
ATOM   2435 C  CA    . VAL B 1 32  ? -2.839  -24.481 -47.736 1.00 60.90  ? 41  VAL B CA    1 
ATOM   2436 C  C     . VAL B 1 32  ? -1.392  -24.190 -48.144 1.00 62.07  ? 41  VAL B C     1 
ATOM   2437 O  O     . VAL B 1 32  ? -1.207  -23.479 -49.165 1.00 69.44  ? 41  VAL B O     1 
ATOM   2438 C  CB    . VAL B 1 32  ? -3.234  -23.697 -46.469 1.00 58.29  ? 41  VAL B CB    1 
ATOM   2439 C  CG1   . VAL B 1 32  ? -2.722  -22.251 -46.500 1.00 46.43  ? 41  VAL B CG1   1 
ATOM   2440 C  CG2   . VAL B 1 32  ? -4.741  -23.736 -46.273 1.00 53.80  ? 41  VAL B CG2   1 
ATOM   2441 N  N     . TRP B 1 33  ? -0.419  -24.743 -47.410 1.00 60.42  ? 42  TRP B N     1 
ATOM   2442 C  CA    . TRP B 1 33  ? 1.034   -24.621 -47.730 1.00 62.87  ? 42  TRP B CA    1 
ATOM   2443 C  C     . TRP B 1 33  ? 1.319   -25.124 -49.158 1.00 57.79  ? 42  TRP B C     1 
ATOM   2444 O  O     . TRP B 1 33  ? 1.949   -24.396 -49.897 1.00 47.94  ? 42  TRP B O     1 
ATOM   2445 C  CB    . TRP B 1 33  ? 1.911   -25.339 -46.698 1.00 57.56  ? 42  TRP B CB    1 
ATOM   2446 C  CG    . TRP B 1 33  ? 2.054   -24.599 -45.407 1.00 52.19  ? 42  TRP B CG    1 
ATOM   2447 C  CD1   . TRP B 1 33  ? 2.281   -23.266 -45.249 1.00 61.01  ? 42  TRP B CD1   1 
ATOM   2448 C  CD2   . TRP B 1 33  ? 2.019   -25.154 -44.078 1.00 53.16  ? 42  TRP B CD2   1 
ATOM   2449 N  NE1   . TRP B 1 33  ? 2.357   -22.947 -43.920 1.00 58.55  ? 42  TRP B NE1   1 
ATOM   2450 C  CE2   . TRP B 1 33  ? 2.208   -24.088 -43.178 1.00 53.16  ? 42  TRP B CE2   1 
ATOM   2451 C  CE3   . TRP B 1 33  ? 1.848   -26.441 -43.557 1.00 60.79  ? 42  TRP B CE3   1 
ATOM   2452 C  CZ2   . TRP B 1 33  ? 2.219   -24.269 -41.798 1.00 54.94  ? 42  TRP B CZ2   1 
ATOM   2453 C  CZ3   . TRP B 1 33  ? 1.860   -26.622 -42.191 1.00 68.06  ? 42  TRP B CZ3   1 
ATOM   2454 C  CH2   . TRP B 1 33  ? 2.049   -25.548 -41.321 1.00 62.40  ? 42  TRP B CH2   1 
ATOM   2455 N  N     . GLN B 1 34  ? 0.815   -26.294 -49.549 1.00 59.00  ? 43  GLN B N     1 
ATOM   2456 C  CA    . GLN B 1 34  ? 1.133   -26.944 -50.856 1.00 64.48  ? 43  GLN B CA    1 
ATOM   2457 C  C     . GLN B 1 34  ? 0.560   -26.167 -52.059 1.00 63.16  ? 43  GLN B C     1 
ATOM   2458 O  O     . GLN B 1 34  ? 1.082   -26.353 -53.160 1.00 59.76  ? 43  GLN B O     1 
ATOM   2459 C  CB    . GLN B 1 34  ? 0.603   -28.380 -50.863 1.00 70.11  ? 43  GLN B CB    1 
ATOM   2460 C  CG    . GLN B 1 34  ? 1.403   -29.338 -49.983 1.00 73.11  ? 43  GLN B CG    1 
ATOM   2461 C  CD    . GLN B 1 34  ? 1.057   -30.774 -50.285 1.00 80.07  ? 43  GLN B CD    1 
ATOM   2462 O  OE1   . GLN B 1 34  ? 0.624   -31.527 -49.420 1.00 83.55  ? 43  GLN B OE1   1 
ATOM   2463 N  NE2   . GLN B 1 34  ? 1.237   -31.167 -51.535 1.00 87.63  ? 43  GLN B NE2   1 
ATOM   2464 N  N     . SER B 1 35  ? -0.470  -25.345 -51.867 1.00 56.02  ? 44  SER B N     1 
ATOM   2465 C  CA    . SER B 1 35  ? -1.297  -24.764 -52.954 1.00 59.32  ? 44  SER B CA    1 
ATOM   2466 C  C     . SER B 1 35  ? -0.738  -23.401 -53.357 1.00 60.26  ? 44  SER B C     1 
ATOM   2467 O  O     . SER B 1 35  ? -0.089  -22.762 -52.516 1.00 66.01  ? 44  SER B O     1 
ATOM   2468 C  CB    . SER B 1 35  ? -2.747  -24.632 -52.530 1.00 63.82  ? 44  SER B CB    1 
ATOM   2469 O  OG    . SER B 1 35  ? -3.317  -25.895 -52.245 1.00 62.20  ? 44  SER B OG    1 
ATOM   2470 N  N     . SER B 1 36  ? -1.014  -22.985 -54.596 1.00 54.43  ? 45  SER B N     1 
ATOM   2471 C  CA    . SER B 1 36  ? -0.694  -21.647 -55.144 1.00 57.18  ? 45  SER B CA    1 
ATOM   2472 C  C     . SER B 1 36  ? -1.980  -20.826 -55.251 1.00 61.26  ? 45  SER B C     1 
ATOM   2473 O  O     . SER B 1 36  ? -1.867  -19.635 -55.493 1.00 62.16  ? 45  SER B O     1 
ATOM   2474 C  CB    . SER B 1 36  ? 0.022   -21.746 -56.486 1.00 65.68  ? 45  SER B CB    1 
ATOM   2475 O  OG    . SER B 1 36  ? -0.420  -22.863 -57.254 1.00 63.48  ? 45  SER B OG    1 
ATOM   2476 N  N     . SER B 1 37  ? -3.160  -21.438 -55.111 1.00 60.26  ? 46  SER B N     1 
ATOM   2477 C  CA    . SER B 1 37  ? -4.441  -20.757 -55.435 1.00 62.78  ? 46  SER B CA    1 
ATOM   2478 C  C     . SER B 1 37  ? -5.577  -21.354 -54.605 1.00 56.41  ? 46  SER B C     1 
ATOM   2479 O  O     . SER B 1 37  ? -6.126  -22.393 -55.010 1.00 54.29  ? 46  SER B O     1 
ATOM   2480 C  CB    . SER B 1 37  ? -4.729  -20.807 -56.927 1.00 61.19  ? 46  SER B CB    1 
ATOM   2481 O  OG    . SER B 1 37  ? -5.644  -19.782 -57.285 1.00 62.90  ? 46  SER B OG    1 
ATOM   2482 N  N     . VAL B 1 38  ? -5.918  -20.684 -53.499 1.00 54.53  ? 47  VAL B N     1 
ATOM   2483 C  CA    . VAL B 1 38  ? -6.908  -21.156 -52.492 1.00 49.65  ? 47  VAL B CA    1 
ATOM   2484 C  C     . VAL B 1 38  ? -8.160  -20.294 -52.592 1.00 47.72  ? 47  VAL B C     1 
ATOM   2485 O  O     . VAL B 1 38  ? -8.043  -19.093 -52.426 1.00 54.35  ? 47  VAL B O     1 
ATOM   2486 C  CB    . VAL B 1 38  ? -6.333  -21.095 -51.071 1.00 49.36  ? 47  VAL B CB    1 
ATOM   2487 C  CG1   . VAL B 1 38  ? -7.275  -21.736 -50.059 1.00 46.37  ? 47  VAL B CG1   1 
ATOM   2488 C  CG2   . VAL B 1 38  ? -4.958  -21.729 -51.016 1.00 50.37  ? 47  VAL B CG2   1 
ATOM   2489 N  N     . VAL B 1 39  ? -9.318  -20.908 -52.798 1.00 43.40  ? 48  VAL B N     1 
ATOM   2490 C  CA    . VAL B 1 39  ? -10.617 -20.219 -52.636 1.00 44.06  ? 48  VAL B CA    1 
ATOM   2491 C  C     . VAL B 1 39  ? -11.336 -20.788 -51.417 1.00 46.18  ? 48  VAL B C     1 
ATOM   2492 O  O     . VAL B 1 39  ? -11.379 -22.000 -51.296 1.00 57.53  ? 48  VAL B O     1 
ATOM   2493 C  CB    . VAL B 1 39  ? -11.478 -20.374 -53.890 1.00 50.77  ? 48  VAL B CB    1 
ATOM   2494 C  CG1   . VAL B 1 39  ? -12.832 -19.713 -53.702 1.00 53.19  ? 48  VAL B CG1   1 
ATOM   2495 C  CG2   . VAL B 1 39  ? -10.743 -19.823 -55.107 1.00 53.33  ? 48  VAL B CG2   1 
ATOM   2496 N  N     . PHE B 1 40  ? -11.892 -19.912 -50.578 1.00 43.58  ? 49  PHE B N     1 
ATOM   2497 C  CA    . PHE B 1 40  ? -12.882 -20.237 -49.532 1.00 45.84  ? 49  PHE B CA    1 
ATOM   2498 C  C     . PHE B 1 40  ? -14.281 -20.009 -50.107 1.00 43.80  ? 49  PHE B C     1 
ATOM   2499 O  O     . PHE B 1 40  ? -14.462 -18.987 -50.781 1.00 45.91  ? 49  PHE B O     1 
ATOM   2500 C  CB    . PHE B 1 40  ? -12.603 -19.393 -48.285 1.00 48.17  ? 49  PHE B CB    1 
ATOM   2501 C  CG    . PHE B 1 40  ? -11.424 -19.896 -47.494 1.00 46.02  ? 49  PHE B CG    1 
ATOM   2502 C  CD1   . PHE B 1 40  ? -10.131 -19.517 -47.825 1.00 51.81  ? 49  PHE B CD1   1 
ATOM   2503 C  CD2   . PHE B 1 40  ? -11.604 -20.776 -46.442 1.00 50.51  ? 49  PHE B CD2   1 
ATOM   2504 C  CE1   . PHE B 1 40  ? -9.042  -20.001 -47.114 1.00 51.22  ? 49  PHE B CE1   1 
ATOM   2505 C  CE2   . PHE B 1 40  ? -10.519 -21.250 -45.713 1.00 50.05  ? 49  PHE B CE2   1 
ATOM   2506 C  CZ    . PHE B 1 40  ? -9.239  -20.872 -46.058 1.00 52.30  ? 49  PHE B CZ    1 
ATOM   2507 N  N     . HIS B 1 41  ? -15.210 -20.946 -49.874 1.00 42.11  ? 50  HIS B N     1 
ATOM   2508 C  CA    . HIS B 1 41  ? -16.679 -20.736 -50.014 1.00 45.35  ? 50  HIS B CA    1 
ATOM   2509 C  C     . HIS B 1 41  ? -17.374 -20.837 -48.650 1.00 39.49  ? 50  HIS B C     1 
ATOM   2510 O  O     . HIS B 1 41  ? -17.139 -21.826 -47.925 1.00 42.81  ? 50  HIS B O     1 
ATOM   2511 C  CB    . HIS B 1 41  ? -17.279 -21.742 -50.982 1.00 46.53  ? 50  HIS B CB    1 
ATOM   2512 C  CG    . HIS B 1 41  ? -16.505 -21.915 -52.245 1.00 41.64  ? 50  HIS B CG    1 
ATOM   2513 N  ND1   . HIS B 1 41  ? -15.205 -22.360 -52.256 1.00 44.87  ? 50  HIS B ND1   1 
ATOM   2514 C  CD2   . HIS B 1 41  ? -16.889 -21.792 -53.530 1.00 42.72  ? 50  HIS B CD2   1 
ATOM   2515 C  CE1   . HIS B 1 41  ? -14.806 -22.501 -53.503 1.00 49.18  ? 50  HIS B CE1   1 
ATOM   2516 N  NE2   . HIS B 1 41  ? -15.825 -22.141 -54.311 1.00 47.51  ? 50  HIS B NE2   1 
ATOM   2517 N  N     . THR B 1 42  ? -18.166 -19.836 -48.284 1.00 40.37  ? 51  THR B N     1 
ATOM   2518 C  CA    . THR B 1 42  ? -18.733 -19.710 -46.913 1.00 44.01  ? 51  THR B CA    1 
ATOM   2519 C  C     . THR B 1 42  ? -20.257 -19.663 -46.966 1.00 39.27  ? 51  THR B C     1 
ATOM   2520 O  O     . THR B 1 42  ? -20.783 -18.984 -47.798 1.00 38.93  ? 51  THR B O     1 
ATOM   2521 C  CB    . THR B 1 42  ? -18.194 -18.487 -46.153 1.00 45.23  ? 51  THR B CB    1 
ATOM   2522 O  OG1   . THR B 1 42  ? -18.551 -17.308 -46.853 1.00 43.09  ? 51  THR B OG1   1 
ATOM   2523 C  CG2   . THR B 1 42  ? -16.695 -18.491 -45.968 1.00 46.50  ? 51  THR B CG2   1 
ATOM   2524 N  N     . GLY B 1 43  ? -20.918 -20.346 -46.038 1.00 43.96  ? 52  GLY B N     1 
ATOM   2525 C  CA    . GLY B 1 43  ? -22.361 -20.180 -45.804 1.00 44.59  ? 52  GLY B CA    1 
ATOM   2526 C  C     . GLY B 1 43  ? -22.661 -19.832 -44.348 1.00 48.44  ? 52  GLY B C     1 
ATOM   2527 O  O     . GLY B 1 43  ? -21.688 -19.706 -43.514 1.00 42.38  ? 52  GLY B O     1 
ATOM   2528 N  N     . ALA B 1 44  ? -23.966 -19.805 -44.036 1.00 44.40  ? 53  ALA B N     1 
ATOM   2529 C  CA    . ALA B 1 44  ? -24.588 -19.258 -42.805 1.00 46.94  ? 53  ALA B CA    1 
ATOM   2530 C  C     . ALA B 1 44  ? -23.909 -19.791 -41.533 1.00 42.16  ? 53  ALA B C     1 
ATOM   2531 O  O     . ALA B 1 44  ? -24.036 -19.133 -40.470 1.00 42.56  ? 53  ALA B O     1 
ATOM   2532 C  CB    . ALA B 1 44  ? -26.062 -19.581 -42.820 1.00 50.00  ? 53  ALA B CB    1 
ATOM   2533 N  N     . GLY B 1 45  ? -23.205 -20.916 -41.645 1.00 41.90  ? 54  GLY B N     1 
ATOM   2534 C  CA    . GLY B 1 45  ? -22.581 -21.634 -40.520 1.00 46.21  ? 54  GLY B CA    1 
ATOM   2535 C  C     . GLY B 1 45  ? -21.468 -20.823 -39.872 1.00 47.21  ? 54  GLY B C     1 
ATOM   2536 O  O     . GLY B 1 45  ? -21.272 -20.975 -38.645 1.00 50.29  ? 54  GLY B O     1 
ATOM   2537 N  N     . ILE B 1 46  ? -20.787 -19.968 -40.636 1.00 41.49  ? 55  ILE B N     1 
ATOM   2538 C  CA    . ILE B 1 46  ? -19.681 -19.130 -40.087 1.00 36.66  ? 55  ILE B CA    1 
ATOM   2539 C  C     . ILE B 1 46  ? -20.252 -17.984 -39.253 1.00 39.71  ? 55  ILE B C     1 
ATOM   2540 O  O     . ILE B 1 46  ? -19.420 -17.310 -38.588 1.00 38.65  ? 55  ILE B O     1 
ATOM   2541 C  CB    . ILE B 1 46  ? -18.722 -18.620 -41.179 1.00 40.27  ? 55  ILE B CB    1 
ATOM   2542 C  CG1   . ILE B 1 46  ? -19.362 -17.594 -42.112 1.00 42.52  ? 55  ILE B CG1   1 
ATOM   2543 C  CG2   . ILE B 1 46  ? -18.086 -19.765 -41.963 1.00 39.62  ? 55  ILE B CG2   1 
ATOM   2544 C  CD1   . ILE B 1 46  ? -18.344 -16.871 -42.976 1.00 45.28  ? 55  ILE B CD1   1 
ATOM   2545 N  N     . SER B 1 47  ? -21.589 -17.808 -39.229 1.00 40.30  ? 56  SER B N     1 
ATOM   2546 C  CA    . SER B 1 47  ? -22.272 -16.691 -38.526 1.00 40.21  ? 56  SER B CA    1 
ATOM   2547 C  C     . SER B 1 47  ? -23.097 -17.119 -37.306 1.00 39.11  ? 56  SER B C     1 
ATOM   2548 O  O     . SER B 1 47  ? -23.555 -16.210 -36.567 1.00 40.55  ? 56  SER B O     1 
ATOM   2549 C  CB    . SER B 1 47  ? -23.093 -15.896 -39.496 1.00 38.64  ? 56  SER B CB    1 
ATOM   2550 O  OG    . SER B 1 47  ? -22.230 -15.129 -40.306 1.00 41.08  ? 56  SER B OG    1 
ATOM   2551 N  N     . THR B 1 48  ? -23.287 -18.417 -37.076 1.00 43.83  ? 57  THR B N     1 
ATOM   2552 C  CA    . THR B 1 48  ? -24.084 -18.949 -35.939 1.00 39.88  ? 57  THR B CA    1 
ATOM   2553 C  C     . THR B 1 48  ? -23.481 -18.498 -34.607 1.00 43.77  ? 57  THR B C     1 
ATOM   2554 O  O     . THR B 1 48  ? -24.278 -18.085 -33.738 1.00 49.96  ? 57  THR B O     1 
ATOM   2555 C  CB    . THR B 1 48  ? -24.279 -20.464 -36.063 1.00 43.66  ? 57  THR B CB    1 
ATOM   2556 O  OG1   . THR B 1 48  ? -23.063 -21.101 -36.476 1.00 38.34  ? 57  THR B OG1   1 
ATOM   2557 C  CG2   . THR B 1 48  ? -25.412 -20.773 -37.020 1.00 43.12  ? 57  THR B CG2   1 
ATOM   2558 N  N     . ALA B 1 49  ? -22.141 -18.478 -34.504 1.00 48.87  ? 58  ALA B N     1 
ATOM   2559 C  CA    . ALA B 1 49  ? -21.346 -18.102 -33.308 1.00 49.49  ? 58  ALA B CA    1 
ATOM   2560 C  C     . ALA B 1 49  ? -21.396 -16.593 -33.040 1.00 51.48  ? 58  ALA B C     1 
ATOM   2561 O  O     . ALA B 1 49  ? -20.995 -16.200 -31.931 1.00 61.82  ? 58  ALA B O     1 
ATOM   2562 C  CB    . ALA B 1 49  ? -19.910 -18.550 -33.458 1.00 53.68  ? 58  ALA B CB    1 
ATOM   2563 N  N     . SER B 1 50  ? -21.873 -15.763 -33.966 1.00 45.71  ? 59  SER B N     1 
ATOM   2564 C  CA    . SER B 1 50  ? -22.185 -14.332 -33.680 1.00 42.09  ? 59  SER B CA    1 
ATOM   2565 C  C     . SER B 1 50  ? -23.702 -14.118 -33.469 1.00 40.80  ? 59  SER B C     1 
ATOM   2566 O  O     . SER B 1 50  ? -24.119 -12.976 -33.322 1.00 41.08  ? 59  SER B O     1 
ATOM   2567 C  CB    . SER B 1 50  ? -21.629 -13.456 -34.752 1.00 46.00  ? 59  SER B CB    1 
ATOM   2568 O  OG    . SER B 1 50  ? -22.234 -13.784 -36.004 1.00 65.83  ? 59  SER B OG    1 
ATOM   2569 N  N     . GLY B 1 51  ? -24.504 -15.182 -33.395 1.00 45.24  ? 60  GLY B N     1 
ATOM   2570 C  CA    . GLY B 1 51  ? -25.897 -15.137 -32.893 1.00 45.15  ? 60  GLY B CA    1 
ATOM   2571 C  C     . GLY B 1 51  ? -26.940 -15.160 -33.998 1.00 46.25  ? 60  GLY B C     1 
ATOM   2572 O  O     . GLY B 1 51  ? -28.147 -14.908 -33.681 1.00 46.33  ? 60  GLY B O     1 
ATOM   2573 N  N     . ILE B 1 52  ? -26.505 -15.431 -35.238 1.00 45.42  ? 61  ILE B N     1 
ATOM   2574 C  CA    . ILE B 1 52  ? -27.348 -15.459 -36.469 1.00 42.32  ? 61  ILE B CA    1 
ATOM   2575 C  C     . ILE B 1 52  ? -27.581 -16.923 -36.843 1.00 45.97  ? 61  ILE B C     1 
ATOM   2576 O  O     . ILE B 1 52  ? -26.643 -17.645 -37.158 1.00 52.12  ? 61  ILE B O     1 
ATOM   2577 C  CB    . ILE B 1 52  ? -26.665 -14.695 -37.618 1.00 41.50  ? 61  ILE B CB    1 
ATOM   2578 C  CG1   . ILE B 1 52  ? -26.643 -13.188 -37.369 1.00 44.16  ? 61  ILE B CG1   1 
ATOM   2579 C  CG2   . ILE B 1 52  ? -27.332 -15.048 -38.944 1.00 38.62  ? 61  ILE B CG2   1 
ATOM   2580 C  CD1   . ILE B 1 52  ? -25.691 -12.426 -38.262 1.00 46.81  ? 61  ILE B CD1   1 
ATOM   2581 N  N     . PRO B 1 53  ? -28.830 -17.419 -36.835 1.00 41.51  ? 62  PRO B N     1 
ATOM   2582 C  CA    . PRO B 1 53  ? -29.089 -18.823 -37.115 1.00 46.50  ? 62  PRO B CA    1 
ATOM   2583 C  C     . PRO B 1 53  ? -28.958 -19.148 -38.607 1.00 49.82  ? 62  PRO B C     1 
ATOM   2584 O  O     . PRO B 1 53  ? -29.127 -18.270 -39.430 1.00 49.51  ? 62  PRO B O     1 
ATOM   2585 C  CB    . PRO B 1 53  ? -30.543 -18.978 -36.688 1.00 42.75  ? 62  PRO B CB    1 
ATOM   2586 C  CG    . PRO B 1 53  ? -31.143 -17.633 -36.971 1.00 40.32  ? 62  PRO B CG    1 
ATOM   2587 C  CD    . PRO B 1 53  ? -30.062 -16.647 -36.635 1.00 46.42  ? 62  PRO B CD    1 
ATOM   2588 N  N     . ASP B 1 54  ? -28.644 -20.404 -38.882 1.00 49.50  ? 63  ASP B N     1 
ATOM   2589 C  CA    . ASP B 1 54  ? -28.426 -20.938 -40.243 1.00 49.50  ? 63  ASP B CA    1 
ATOM   2590 C  C     . ASP B 1 54  ? -29.813 -21.258 -40.788 1.00 54.16  ? 63  ASP B C     1 
ATOM   2591 O  O     . ASP B 1 54  ? -30.788 -20.775 -40.172 1.00 53.65  ? 63  ASP B O     1 
ATOM   2592 C  CB    . ASP B 1 54  ? -27.434 -22.106 -40.230 1.00 48.02  ? 63  ASP B CB    1 
ATOM   2593 C  CG    . ASP B 1 54  ? -27.874 -23.342 -39.473 1.00 43.73  ? 63  ASP B CG    1 
ATOM   2594 O  OD1   . ASP B 1 54  ? -29.085 -23.548 -39.353 1.00 45.11  ? 63  ASP B OD1   1 
ATOM   2595 O  OD2   . ASP B 1 54  ? -26.992 -24.086 -39.005 1.00 50.13  ? 63  ASP B OD2   1 
ATOM   2596 N  N     . PHE B 1 55  ? -29.892 -22.012 -41.888 1.00 50.57  ? 64  PHE B N     1 
ATOM   2597 C  CA    . PHE B 1 55  ? -31.170 -22.359 -42.545 1.00 50.66  ? 64  PHE B CA    1 
ATOM   2598 C  C     . PHE B 1 55  ? -31.517 -23.822 -42.269 1.00 55.97  ? 64  PHE B C     1 
ATOM   2599 O  O     . PHE B 1 55  ? -32.701 -24.073 -41.937 1.00 51.75  ? 64  PHE B O     1 
ATOM   2600 C  CB    . PHE B 1 55  ? -31.091 -22.046 -44.037 1.00 55.17  ? 64  PHE B CB    1 
ATOM   2601 C  CG    . PHE B 1 55  ? -31.014 -20.576 -44.361 1.00 50.07  ? 64  PHE B CG    1 
ATOM   2602 C  CD1   . PHE B 1 55  ? -32.160 -19.809 -44.469 1.00 55.21  ? 64  PHE B CD1   1 
ATOM   2603 C  CD2   . PHE B 1 55  ? -29.791 -19.963 -44.577 1.00 54.61  ? 64  PHE B CD2   1 
ATOM   2604 C  CE1   . PHE B 1 55  ? -32.083 -18.456 -44.769 1.00 59.04  ? 64  PHE B CE1   1 
ATOM   2605 C  CE2   . PHE B 1 55  ? -29.711 -18.616 -44.902 1.00 56.18  ? 64  PHE B CE2   1 
ATOM   2606 C  CZ    . PHE B 1 55  ? -30.859 -17.860 -44.982 1.00 57.84  ? 64  PHE B CZ    1 
ATOM   2607 N  N     . ARG B 1 56  ? -30.543 -24.735 -42.415 1.00 54.82  ? 65  ARG B N     1 
ATOM   2608 C  CA    . ARG B 1 56  ? -30.774 -26.207 -42.483 1.00 53.39  ? 65  ARG B CA    1 
ATOM   2609 C  C     . ARG B 1 56  ? -30.112 -26.927 -41.303 1.00 51.79  ? 65  ARG B C     1 
ATOM   2610 O  O     . ARG B 1 56  ? -29.981 -28.157 -41.357 1.00 60.10  ? 65  ARG B O     1 
ATOM   2611 C  CB    . ARG B 1 56  ? -30.259 -26.777 -43.811 1.00 48.40  ? 65  ARG B CB    1 
ATOM   2612 C  CG    . ARG B 1 56  ? -30.907 -26.153 -45.039 1.00 54.82  ? 65  ARG B CG    1 
ATOM   2613 C  CD    . ARG B 1 56  ? -30.614 -26.837 -46.374 1.00 49.33  ? 65  ARG B CD    1 
ATOM   2614 N  NE    . ARG B 1 56  ? -31.298 -26.064 -47.393 1.00 53.64  ? 65  ARG B NE    1 
ATOM   2615 C  CZ    . ARG B 1 56  ? -30.883 -24.899 -47.908 1.00 56.35  ? 65  ARG B CZ    1 
ATOM   2616 N  NH1   . ARG B 1 56  ? -29.738 -24.340 -47.550 1.00 57.11  ? 65  ARG B NH1   1 
ATOM   2617 N  NH2   . ARG B 1 56  ? -31.635 -24.278 -48.791 1.00 61.32  ? 65  ARG B NH2   1 
ATOM   2618 N  N     . GLY B 1 57  ? -29.714 -26.223 -40.254 1.00 50.37  ? 66  GLY B N     1 
ATOM   2619 C  CA    . GLY B 1 57  ? -29.166 -26.899 -39.055 1.00 51.18  ? 66  GLY B CA    1 
ATOM   2620 C  C     . GLY B 1 57  ? -30.282 -27.216 -38.063 1.00 46.70  ? 66  GLY B C     1 
ATOM   2621 O  O     . GLY B 1 57  ? -31.412 -26.804 -38.270 1.00 51.22  ? 66  GLY B O     1 
ATOM   2622 N  N     . PRO B 1 58  ? -29.991 -27.861 -36.916 1.00 52.22  ? 67  PRO B N     1 
ATOM   2623 C  CA    . PRO B 1 58  ? -31.028 -28.189 -35.934 1.00 50.25  ? 67  PRO B CA    1 
ATOM   2624 C  C     . PRO B 1 58  ? -31.984 -27.026 -35.627 1.00 45.15  ? 67  PRO B C     1 
ATOM   2625 O  O     . PRO B 1 58  ? -33.178 -27.226 -35.598 1.00 42.16  ? 67  PRO B O     1 
ATOM   2626 C  CB    . PRO B 1 58  ? -30.230 -28.517 -34.659 1.00 49.51  ? 67  PRO B CB    1 
ATOM   2627 C  CG    . PRO B 1 58  ? -28.887 -29.015 -35.187 1.00 50.10  ? 67  PRO B CG    1 
ATOM   2628 C  CD    . PRO B 1 58  ? -28.637 -28.251 -36.471 1.00 50.13  ? 67  PRO B CD    1 
ATOM   2629 N  N     . HIS B 1 59  ? -31.450 -25.841 -35.384 1.00 48.43  ? 68  HIS B N     1 
ATOM   2630 C  CA    . HIS B 1 59  ? -32.252 -24.642 -34.995 1.00 56.59  ? 68  HIS B CA    1 
ATOM   2631 C  C     . HIS B 1 59  ? -32.318 -23.673 -36.186 1.00 51.91  ? 68  HIS B C     1 
ATOM   2632 O  O     . HIS B 1 59  ? -32.582 -22.506 -35.983 1.00 52.19  ? 68  HIS B O     1 
ATOM   2633 C  CB    . HIS B 1 59  ? -31.708 -24.095 -33.670 1.00 47.73  ? 68  HIS B CB    1 
ATOM   2634 C  CG    . HIS B 1 59  ? -32.046 -24.974 -32.500 1.00 52.19  ? 68  HIS B CG    1 
ATOM   2635 N  ND1   . HIS B 1 59  ? -31.935 -24.546 -31.184 1.00 53.51  ? 68  HIS B ND1   1 
ATOM   2636 C  CD2   . HIS B 1 59  ? -32.515 -26.243 -32.429 1.00 50.51  ? 68  HIS B CD2   1 
ATOM   2637 C  CE1   . HIS B 1 59  ? -32.267 -25.526 -30.366 1.00 46.76  ? 68  HIS B CE1   1 
ATOM   2638 N  NE2   . HIS B 1 59  ? -32.649 -26.563 -31.100 1.00 51.39  ? 68  HIS B NE2   1 
ATOM   2639 N  N     . GLY B 1 60  ? -32.138 -24.195 -37.399 1.00 53.91  ? 69  GLY B N     1 
ATOM   2640 C  CA    . GLY B 1 60  ? -32.105 -23.408 -38.646 1.00 52.82  ? 69  GLY B CA    1 
ATOM   2641 C  C     . GLY B 1 60  ? -33.489 -22.994 -39.103 1.00 50.49  ? 69  GLY B C     1 
ATOM   2642 O  O     . GLY B 1 60  ? -34.451 -23.734 -38.870 1.00 62.41  ? 69  GLY B O     1 
ATOM   2643 N  N     . VAL B 1 61  ? -33.564 -21.828 -39.728 1.00 55.15  ? 70  VAL B N     1 
ATOM   2644 C  CA    . VAL B 1 61  ? -34.810 -21.159 -40.208 1.00 60.24  ? 70  VAL B CA    1 
ATOM   2645 C  C     . VAL B 1 61  ? -35.746 -22.187 -40.859 1.00 58.19  ? 70  VAL B C     1 
ATOM   2646 O  O     . VAL B 1 61  ? -36.885 -22.263 -40.412 1.00 56.29  ? 70  VAL B O     1 
ATOM   2647 C  CB    . VAL B 1 61  ? -34.486 -20.021 -41.198 1.00 60.95  ? 70  VAL B CB    1 
ATOM   2648 C  CG1   . VAL B 1 61  ? -35.751 -19.337 -41.674 1.00 66.84  ? 70  VAL B CG1   1 
ATOM   2649 C  CG2   . VAL B 1 61  ? -33.532 -18.994 -40.608 1.00 58.95  ? 70  VAL B CG2   1 
ATOM   2650 N  N     . TRP B 1 62  ? -35.306 -22.908 -41.900 1.00 59.48  ? 71  TRP B N     1 
ATOM   2651 C  CA    . TRP B 1 62  ? -36.160 -23.922 -42.584 1.00 63.53  ? 71  TRP B CA    1 
ATOM   2652 C  C     . TRP B 1 62  ? -36.549 -25.018 -41.583 1.00 63.69  ? 71  TRP B C     1 
ATOM   2653 O  O     . TRP B 1 62  ? -37.741 -25.388 -41.536 1.00 65.22  ? 71  TRP B O     1 
ATOM   2654 C  CB    . TRP B 1 62  ? -35.499 -24.506 -43.847 1.00 59.63  ? 71  TRP B CB    1 
ATOM   2655 C  CG    . TRP B 1 62  ? -35.090 -23.512 -44.894 1.00 60.58  ? 71  TRP B CG    1 
ATOM   2656 C  CD1   . TRP B 1 62  ? -34.107 -23.691 -45.831 1.00 73.28  ? 71  TRP B CD1   1 
ATOM   2657 C  CD2   . TRP B 1 62  ? -35.584 -22.174 -45.099 1.00 67.06  ? 71  TRP B CD2   1 
ATOM   2658 N  NE1   . TRP B 1 62  ? -33.966 -22.574 -46.613 1.00 70.17  ? 71  TRP B NE1   1 
ATOM   2659 C  CE2   . TRP B 1 62  ? -34.854 -21.624 -46.185 1.00 67.15  ? 71  TRP B CE2   1 
ATOM   2660 C  CE3   . TRP B 1 62  ? -36.556 -21.374 -44.476 1.00 72.71  ? 71  TRP B CE3   1 
ATOM   2661 C  CZ2   . TRP B 1 62  ? -35.084 -20.336 -46.665 1.00 68.83  ? 71  TRP B CZ2   1 
ATOM   2662 C  CZ3   . TRP B 1 62  ? -36.780 -20.096 -44.950 1.00 78.57  ? 71  TRP B CZ3   1 
ATOM   2663 C  CH2   . TRP B 1 62  ? -36.050 -19.584 -46.028 1.00 76.62  ? 71  TRP B CH2   1 
ATOM   2664 N  N     . THR B 1 63  ? -35.576 -25.507 -40.812 1.00 67.74  ? 72  THR B N     1 
ATOM   2665 C  CA    . THR B 1 63  ? -35.739 -26.615 -39.839 1.00 66.77  ? 72  THR B CA    1 
ATOM   2666 C  C     . THR B 1 63  ? -36.765 -26.218 -38.780 1.00 65.51  ? 72  THR B C     1 
ATOM   2667 O  O     . THR B 1 63  ? -37.661 -27.028 -38.499 1.00 69.99  ? 72  THR B O     1 
ATOM   2668 C  CB    . THR B 1 63  ? -34.386 -27.027 -39.252 1.00 68.51  ? 72  THR B CB    1 
ATOM   2669 O  OG1   . THR B 1 63  ? -33.585 -27.364 -40.387 1.00 67.56  ? 72  THR B OG1   1 
ATOM   2670 C  CG2   . THR B 1 63  ? -34.469 -28.197 -38.293 1.00 63.31  ? 72  THR B CG2   1 
ATOM   2671 N  N     . MET B 1 64  ? -36.665 -25.014 -38.225 1.00 69.30  ? 73  MET B N     1 
ATOM   2672 C  CA    . MET B 1 64  ? -37.629 -24.574 -37.192 1.00 66.65  ? 73  MET B CA    1 
ATOM   2673 C  C     . MET B 1 64  ? -39.026 -24.490 -37.815 1.00 65.73  ? 73  MET B C     1 
ATOM   2674 O  O     . MET B 1 64  ? -39.968 -24.973 -37.179 1.00 78.57  ? 73  MET B O     1 
ATOM   2675 C  CB    . MET B 1 64  ? -37.223 -23.248 -36.548 1.00 70.91  ? 73  MET B CB    1 
ATOM   2676 C  CG    . MET B 1 64  ? -36.191 -23.412 -35.428 1.00 77.54  ? 73  MET B CG    1 
ATOM   2677 S  SD    . MET B 1 64  ? -36.135 -25.066 -34.652 1.00 68.69  ? 73  MET B SD    1 
ATOM   2678 C  CE    . MET B 1 64  ? -35.867 -24.600 -32.943 1.00 69.50  ? 73  MET B CE    1 
ATOM   2679 N  N     . GLU B 1 65  ? -39.156 -23.930 -39.018 1.00 70.20  ? 74  GLU B N     1 
ATOM   2680 C  CA    . GLU B 1 65  ? -40.464 -23.795 -39.723 1.00 70.36  ? 74  GLU B CA    1 
ATOM   2681 C  C     . GLU B 1 65  ? -41.192 -25.153 -39.729 1.00 83.92  ? 74  GLU B C     1 
ATOM   2682 O  O     . GLU B 1 65  ? -42.358 -25.194 -39.268 1.00 78.80  ? 74  GLU B O     1 
ATOM   2683 C  CB    . GLU B 1 65  ? -40.266 -23.244 -41.138 1.00 66.02  ? 74  GLU B CB    1 
ATOM   2684 C  CG    . GLU B 1 65  ? -40.737 -21.809 -41.272 1.00 73.97  ? 74  GLU B CG    1 
ATOM   2685 C  CD    . GLU B 1 65  ? -39.986 -20.921 -42.248 1.00 76.30  ? 74  GLU B CD    1 
ATOM   2686 O  OE1   . GLU B 1 65  ? -39.836 -21.313 -43.423 1.00 82.95  ? 74  GLU B OE1   1 
ATOM   2687 O  OE2   . GLU B 1 65  ? -39.575 -19.821 -41.833 1.00 77.29  ? 74  GLU B OE2   1 
ATOM   2688 N  N     . GLU B 1 66  ? -40.524 -26.217 -40.196 1.00 75.00  ? 75  GLU B N     1 
ATOM   2689 C  CA    . GLU B 1 66  ? -41.083 -27.587 -40.286 1.00 71.50  ? 75  GLU B CA    1 
ATOM   2690 C  C     . GLU B 1 66  ? -41.613 -28.062 -38.932 1.00 82.42  ? 75  GLU B C     1 
ATOM   2691 O  O     . GLU B 1 66  ? -42.713 -28.618 -38.926 1.00 100.43 ? 75  GLU B O     1 
ATOM   2692 C  CB    . GLU B 1 66  ? -40.037 -28.576 -40.768 1.00 73.69  ? 75  GLU B CB    1 
ATOM   2693 C  CG    . GLU B 1 66  ? -39.920 -28.614 -42.268 1.00 71.41  ? 75  GLU B CG    1 
ATOM   2694 C  CD    . GLU B 1 66  ? -38.603 -29.205 -42.719 1.00 74.83  ? 75  GLU B CD    1 
ATOM   2695 O  OE1   . GLU B 1 66  ? -37.956 -29.895 -41.885 1.00 73.02  ? 75  GLU B OE1   1 
ATOM   2696 O  OE2   . GLU B 1 66  ? -38.215 -28.948 -43.878 1.00 70.29  ? 75  GLU B OE2   1 
ATOM   2697 N  N     . ARG B 1 67  ? -40.879 -27.873 -37.832 1.00 79.26  ? 76  ARG B N     1 
ATOM   2698 C  CA    . ARG B 1 67  ? -41.383 -28.230 -36.474 1.00 86.18  ? 76  ARG B CA    1 
ATOM   2699 C  C     . ARG B 1 67  ? -42.344 -27.128 -36.002 1.00 87.05  ? 76  ARG B C     1 
ATOM   2700 O  O     . ARG B 1 67  ? -42.708 -27.125 -34.808 1.00 88.40  ? 76  ARG B O     1 
ATOM   2701 C  CB    . ARG B 1 67  ? -40.252 -28.423 -35.454 1.00 98.31  ? 76  ARG B CB    1 
ATOM   2702 C  CG    . ARG B 1 67  ? -39.429 -29.698 -35.609 1.00 104.35 ? 76  ARG B CG    1 
ATOM   2703 C  CD    . ARG B 1 67  ? -38.411 -29.587 -36.727 1.00 104.64 ? 76  ARG B CD    1 
ATOM   2704 N  NE    . ARG B 1 67  ? -37.286 -30.508 -36.620 1.00 107.05 ? 76  ARG B NE    1 
ATOM   2705 C  CZ    . ARG B 1 67  ? -36.599 -30.995 -37.659 1.00 113.47 ? 76  ARG B CZ    1 
ATOM   2706 N  NH1   . ARG B 1 67  ? -36.932 -30.671 -38.902 1.00 109.94 ? 76  ARG B NH1   1 
ATOM   2707 N  NH2   . ARG B 1 67  ? -35.583 -31.820 -37.454 1.00 109.76 ? 76  ARG B NH2   1 
ATOM   2708 N  N     . GLY B 1 68  ? -42.747 -26.228 -36.903 1.00 79.35  ? 77  GLY B N     1 
ATOM   2709 C  CA    . GLY B 1 68  ? -43.638 -25.095 -36.605 1.00 77.44  ? 77  GLY B CA    1 
ATOM   2710 C  C     . GLY B 1 68  ? -43.081 -24.253 -35.483 1.00 71.62  ? 77  GLY B C     1 
ATOM   2711 O  O     . GLY B 1 68  ? -43.826 -23.949 -34.544 1.00 78.78  ? 77  GLY B O     1 
ATOM   2712 N  N     . LEU B 1 69  ? -41.796 -23.920 -35.559 1.00 76.78  ? 78  LEU B N     1 
ATOM   2713 C  CA    . LEU B 1 69  ? -41.119 -23.053 -34.560 1.00 74.38  ? 78  LEU B CA    1 
ATOM   2714 C  C     . LEU B 1 69  ? -40.502 -21.863 -35.296 1.00 67.55  ? 78  LEU B C     1 
ATOM   2715 O  O     . LEU B 1 69  ? -40.421 -21.926 -36.540 1.00 72.53  ? 78  LEU B O     1 
ATOM   2716 C  CB    . LEU B 1 69  ? -40.101 -23.896 -33.789 1.00 75.11  ? 78  LEU B CB    1 
ATOM   2717 C  CG    . LEU B 1 69  ? -40.713 -24.770 -32.686 1.00 85.35  ? 78  LEU B CG    1 
ATOM   2718 C  CD1   . LEU B 1 69  ? -40.110 -26.172 -32.679 1.00 82.91  ? 78  LEU B CD1   1 
ATOM   2719 C  CD2   . LEU B 1 69  ? -40.573 -24.113 -31.312 1.00 85.69  ? 78  LEU B CD2   1 
ATOM   2720 N  N     . ALA B 1 70  ? -40.199 -20.791 -34.562 1.00 69.90  ? 79  ALA B N     1 
ATOM   2721 C  CA    . ALA B 1 70  ? -39.461 -19.598 -35.040 1.00 61.63  ? 79  ALA B CA    1 
ATOM   2722 C  C     . ALA B 1 70  ? -37.990 -19.840 -34.760 1.00 64.47  ? 79  ALA B C     1 
ATOM   2723 O  O     . ALA B 1 70  ? -37.660 -20.369 -33.701 1.00 66.18  ? 79  ALA B O     1 
ATOM   2724 C  CB    . ALA B 1 70  ? -39.920 -18.327 -34.368 1.00 59.32  ? 79  ALA B CB    1 
ATOM   2725 N  N     . PRO B 1 71  ? -37.089 -19.485 -35.706 1.00 60.98  ? 80  PRO B N     1 
ATOM   2726 C  CA    . PRO B 1 71  ? -35.656 -19.537 -35.462 1.00 64.62  ? 80  PRO B CA    1 
ATOM   2727 C  C     . PRO B 1 71  ? -35.325 -18.393 -34.494 1.00 65.91  ? 80  PRO B C     1 
ATOM   2728 O  O     . PRO B 1 71  ? -36.112 -17.465 -34.418 1.00 52.84  ? 80  PRO B O     1 
ATOM   2729 C  CB    . PRO B 1 71  ? -35.071 -19.311 -36.864 1.00 65.89  ? 80  PRO B CB    1 
ATOM   2730 C  CG    . PRO B 1 71  ? -36.074 -18.371 -37.488 1.00 60.13  ? 80  PRO B CG    1 
ATOM   2731 C  CD    . PRO B 1 71  ? -37.396 -18.958 -37.046 1.00 62.35  ? 80  PRO B CD    1 
ATOM   2732 N  N     . LYS B 1 72  ? -34.178 -18.471 -33.816 1.00 59.99  ? 81  LYS B N     1 
ATOM   2733 C  CA    . LYS B 1 72  ? -33.765 -17.446 -32.834 1.00 58.68  ? 81  LYS B CA    1 
ATOM   2734 C  C     . LYS B 1 72  ? -32.597 -16.611 -33.378 1.00 54.89  ? 81  LYS B C     1 
ATOM   2735 O  O     . LYS B 1 72  ? -31.606 -17.173 -33.893 1.00 49.50  ? 81  LYS B O     1 
ATOM   2736 C  CB    . LYS B 1 72  ? -33.424 -18.092 -31.492 1.00 64.35  ? 81  LYS B CB    1 
ATOM   2737 C  CG    . LYS B 1 72  ? -34.343 -17.662 -30.362 1.00 63.93  ? 81  LYS B CG    1 
ATOM   2738 C  CD    . LYS B 1 72  ? -34.300 -16.174 -30.072 1.00 63.16  ? 81  LYS B CD    1 
ATOM   2739 C  CE    . LYS B 1 72  ? -33.340 -15.810 -28.955 1.00 66.95  ? 81  LYS B CE    1 
ATOM   2740 N  NZ    . LYS B 1 72  ? -33.466 -14.381 -28.565 1.00 65.76  ? 81  LYS B NZ    1 
ATOM   2741 N  N     . PHE B 1 73  ? -32.746 -15.299 -33.244 1.00 50.43  ? 82  PHE B N     1 
ATOM   2742 C  CA    . PHE B 1 73  ? -31.696 -14.273 -33.405 1.00 49.26  ? 82  PHE B CA    1 
ATOM   2743 C  C     . PHE B 1 73  ? -31.270 -13.863 -31.993 1.00 51.64  ? 82  PHE B C     1 
ATOM   2744 O  O     . PHE B 1 73  ? -32.152 -13.524 -31.213 1.00 51.71  ? 82  PHE B O     1 
ATOM   2745 C  CB    . PHE B 1 73  ? -32.249 -13.115 -34.242 1.00 49.93  ? 82  PHE B CB    1 
ATOM   2746 C  CG    . PHE B 1 73  ? -32.283 -13.411 -35.716 1.00 48.22  ? 82  PHE B CG    1 
ATOM   2747 C  CD1   . PHE B 1 73  ? -33.386 -14.021 -36.290 1.00 49.62  ? 82  PHE B CD1   1 
ATOM   2748 C  CD2   . PHE B 1 73  ? -31.195 -13.103 -36.516 1.00 50.11  ? 82  PHE B CD2   1 
ATOM   2749 C  CE1   . PHE B 1 73  ? -33.395 -14.317 -37.644 1.00 53.99  ? 82  PHE B CE1   1 
ATOM   2750 C  CE2   . PHE B 1 73  ? -31.190 -13.426 -37.864 1.00 51.00  ? 82  PHE B CE2   1 
ATOM   2751 C  CZ    . PHE B 1 73  ? -32.292 -14.031 -38.424 1.00 54.27  ? 82  PHE B CZ    1 
ATOM   2752 N  N     . ASP B 1 74  ? -29.980 -13.972 -31.663 1.00 49.33  ? 83  ASP B N     1 
ATOM   2753 C  CA    . ASP B 1 74  ? -29.392 -13.410 -30.417 1.00 45.48  ? 83  ASP B CA    1 
ATOM   2754 C  C     . ASP B 1 74  ? -28.681 -12.088 -30.720 1.00 47.06  ? 83  ASP B C     1 
ATOM   2755 O  O     . ASP B 1 74  ? -28.023 -11.572 -29.826 1.00 52.90  ? 83  ASP B O     1 
ATOM   2756 C  CB    . ASP B 1 74  ? -28.410 -14.385 -29.795 1.00 45.95  ? 83  ASP B CB    1 
ATOM   2757 C  CG    . ASP B 1 74  ? -29.057 -15.719 -29.535 1.00 50.50  ? 83  ASP B CG    1 
ATOM   2758 O  OD1   . ASP B 1 74  ? -29.893 -15.776 -28.566 1.00 51.78  ? 83  ASP B OD1   1 
ATOM   2759 O  OD2   . ASP B 1 74  ? -28.722 -16.682 -30.296 1.00 43.49  ? 83  ASP B OD2   1 
ATOM   2760 N  N     . THR B 1 75  ? -28.811 -11.561 -31.935 1.00 49.69  ? 84  THR B N     1 
ATOM   2761 C  CA    . THR B 1 75  ? -28.323 -10.204 -32.304 1.00 55.22  ? 84  THR B CA    1 
ATOM   2762 C  C     . THR B 1 75  ? -29.115 -9.646  -33.492 1.00 55.70  ? 84  THR B C     1 
ATOM   2763 O  O     . THR B 1 75  ? -29.778 -10.430 -34.212 1.00 55.17  ? 84  THR B O     1 
ATOM   2764 C  CB    . THR B 1 75  ? -26.828 -10.233 -32.643 1.00 54.35  ? 84  THR B CB    1 
ATOM   2765 O  OG1   . THR B 1 75  ? -26.407 -8.888  -32.862 1.00 57.10  ? 84  THR B OG1   1 
ATOM   2766 C  CG2   . THR B 1 75  ? -26.514 -11.089 -33.848 1.00 57.69  ? 84  THR B CG2   1 
ATOM   2767 N  N     . THR B 1 76  ? -29.066 -8.329  -33.663 1.00 55.78  ? 85  THR B N     1 
ATOM   2768 C  CA    . THR B 1 76  ? -29.557 -7.650  -34.877 1.00 53.54  ? 85  THR B CA    1 
ATOM   2769 C  C     . THR B 1 76  ? -28.467 -7.842  -35.915 1.00 50.10  ? 85  THR B C     1 
ATOM   2770 O  O     . THR B 1 76  ? -27.358 -8.195  -35.515 1.00 45.22  ? 85  THR B O     1 
ATOM   2771 C  CB    . THR B 1 76  ? -29.858 -6.169  -34.658 1.00 51.55  ? 85  THR B CB    1 
ATOM   2772 O  OG1   . THR B 1 76  ? -28.590 -5.574  -34.394 1.00 52.87  ? 85  THR B OG1   1 
ATOM   2773 C  CG2   . THR B 1 76  ? -30.831 -5.927  -33.524 1.00 55.29  ? 85  THR B CG2   1 
ATOM   2774 N  N     . PHE B 1 77  ? -28.804 -7.649  -37.184 1.00 47.54  ? 86  PHE B N     1 
ATOM   2775 C  CA    . PHE B 1 77  ? -27.829 -7.618  -38.293 1.00 47.34  ? 86  PHE B CA    1 
ATOM   2776 C  C     . PHE B 1 77  ? -26.837 -6.483  -38.024 1.00 49.31  ? 86  PHE B C     1 
ATOM   2777 O  O     . PHE B 1 77  ? -25.623 -6.661  -38.256 1.00 54.02  ? 86  PHE B O     1 
ATOM   2778 C  CB    . PHE B 1 77  ? -28.576 -7.564  -39.628 1.00 45.81  ? 86  PHE B CB    1 
ATOM   2779 C  CG    . PHE B 1 77  ? -29.197 -8.888  -39.990 1.00 47.51  ? 86  PHE B CG    1 
ATOM   2780 C  CD1   . PHE B 1 77  ? -28.400 -9.975  -40.291 1.00 48.01  ? 86  PHE B CD1   1 
ATOM   2781 C  CD2   . PHE B 1 77  ? -30.574 -9.062  -39.972 1.00 51.51  ? 86  PHE B CD2   1 
ATOM   2782 C  CE1   . PHE B 1 77  ? -28.967 -11.190 -40.644 1.00 58.86  ? 86  PHE B CE1   1 
ATOM   2783 C  CE2   . PHE B 1 77  ? -31.140 -10.289 -40.273 1.00 47.23  ? 86  PHE B CE2   1 
ATOM   2784 C  CZ    . PHE B 1 77  ? -30.338 -11.347 -40.626 1.00 57.47  ? 86  PHE B CZ    1 
ATOM   2785 N  N     . GLU B 1 78  ? -27.342 -5.372  -37.496 1.00 48.99  ? 87  GLU B N     1 
ATOM   2786 C  CA    . GLU B 1 78  ? -26.563 -4.136  -37.227 1.00 50.08  ? 87  GLU B CA    1 
ATOM   2787 C  C     . GLU B 1 78  ? -25.522 -4.344  -36.121 1.00 49.12  ? 87  GLU B C     1 
ATOM   2788 O  O     . GLU B 1 78  ? -24.411 -3.760  -36.259 1.00 50.66  ? 87  GLU B O     1 
ATOM   2789 C  CB    . GLU B 1 78  ? -27.503 -2.998  -36.848 1.00 45.48  ? 87  GLU B CB    1 
ATOM   2790 C  CG    . GLU B 1 78  ? -28.270 -2.467  -38.037 1.00 49.22  ? 87  GLU B CG    1 
ATOM   2791 C  CD    . GLU B 1 78  ? -29.586 -3.159  -38.355 1.00 56.05  ? 87  GLU B CD    1 
ATOM   2792 O  OE1   . GLU B 1 78  ? -30.017 -4.061  -37.580 1.00 57.50  ? 87  GLU B OE1   1 
ATOM   2793 O  OE2   . GLU B 1 78  ? -30.195 -2.778  -39.375 1.00 58.05  ? 87  GLU B OE2   1 
ATOM   2794 N  N     . SER B 1 79  ? -25.877 -5.081  -35.067 1.00 46.02  ? 88  SER B N     1 
ATOM   2795 C  CA    . SER B 1 79  ? -25.062 -5.302  -33.844 1.00 48.41  ? 88  SER B CA    1 
ATOM   2796 C  C     . SER B 1 79  ? -24.273 -6.620  -33.905 1.00 53.52  ? 88  SER B C     1 
ATOM   2797 O  O     . SER B 1 79  ? -23.590 -6.966  -32.883 1.00 50.40  ? 88  SER B O     1 
ATOM   2798 C  CB    . SER B 1 79  ? -25.930 -5.331  -32.629 1.00 49.84  ? 88  SER B CB    1 
ATOM   2799 O  OG    . SER B 1 79  ? -26.717 -4.154  -32.529 1.00 59.21  ? 88  SER B OG    1 
ATOM   2800 N  N     . ALA B 1 80  ? -24.400 -7.381  -34.989 1.00 43.87  ? 89  ALA B N     1 
ATOM   2801 C  CA    . ALA B 1 80  ? -23.689 -8.665  -35.122 1.00 42.97  ? 89  ALA B CA    1 
ATOM   2802 C  C     . ALA B 1 80  ? -22.199 -8.380  -35.313 1.00 51.17  ? 89  ALA B C     1 
ATOM   2803 O  O     . ALA B 1 80  ? -21.848 -7.550  -36.190 1.00 59.78  ? 89  ALA B O     1 
ATOM   2804 C  CB    . ALA B 1 80  ? -24.241 -9.441  -36.268 1.00 47.25  ? 89  ALA B CB    1 
ATOM   2805 N  N     . ARG B 1 81  ? -21.335 -9.063  -34.557 1.00 55.14  ? 90  ARG B N     1 
ATOM   2806 C  CA    . ARG B 1 81  ? -19.873 -8.923  -34.733 1.00 54.07  ? 90  ARG B CA    1 
ATOM   2807 C  C     . ARG B 1 81  ? -19.375 -10.107 -35.551 1.00 58.85  ? 90  ARG B C     1 
ATOM   2808 O  O     . ARG B 1 81  ? -19.858 -11.230 -35.398 1.00 56.60  ? 90  ARG B O     1 
ATOM   2809 C  CB    . ARG B 1 81  ? -19.186 -8.683  -33.391 1.00 56.79  ? 90  ARG B CB    1 
ATOM   2810 C  CG    . ARG B 1 81  ? -18.676 -9.903  -32.641 1.00 63.95  ? 90  ARG B CG    1 
ATOM   2811 C  CD    . ARG B 1 81  ? -17.647 -9.527  -31.585 1.00 62.64  ? 90  ARG B CD    1 
ATOM   2812 N  NE    . ARG B 1 81  ? -16.293 -9.672  -32.118 1.00 69.41  ? 90  ARG B NE    1 
ATOM   2813 C  CZ    . ARG B 1 81  ? -15.388 -8.698  -32.239 1.00 66.46  ? 90  ARG B CZ    1 
ATOM   2814 N  NH1   . ARG B 1 81  ? -15.659 -7.473  -31.821 1.00 71.57  ? 90  ARG B NH1   1 
ATOM   2815 N  NH2   . ARG B 1 81  ? -14.197 -8.962  -32.758 1.00 64.50  ? 90  ARG B NH2   1 
ATOM   2816 N  N     . PRO B 1 82  ? -18.456 -9.857  -36.509 1.00 53.55  ? 91  PRO B N     1 
ATOM   2817 C  CA    . PRO B 1 82  ? -17.800 -10.923 -37.250 1.00 53.07  ? 91  PRO B CA    1 
ATOM   2818 C  C     . PRO B 1 82  ? -17.120 -11.891 -36.290 1.00 46.84  ? 91  PRO B C     1 
ATOM   2819 O  O     . PRO B 1 82  ? -16.570 -11.444 -35.289 1.00 46.34  ? 91  PRO B O     1 
ATOM   2820 C  CB    . PRO B 1 82  ? -16.730 -10.229 -38.108 1.00 51.40  ? 91  PRO B CB    1 
ATOM   2821 C  CG    . PRO B 1 82  ? -17.255 -8.799  -38.246 1.00 54.59  ? 91  PRO B CG    1 
ATOM   2822 C  CD    . PRO B 1 82  ? -18.040 -8.528  -36.975 1.00 54.85  ? 91  PRO B CD    1 
ATOM   2823 N  N     . THR B 1 83  ? -17.183 -13.169 -36.640 1.00 43.68  ? 92  THR B N     1 
ATOM   2824 C  CA    . THR B 1 83  ? -16.635 -14.277 -35.836 1.00 45.18  ? 92  THR B CA    1 
ATOM   2825 C  C     . THR B 1 83  ? -15.121 -14.349 -36.010 1.00 45.45  ? 92  THR B C     1 
ATOM   2826 O  O     . THR B 1 83  ? -14.572 -13.690 -36.927 1.00 43.29  ? 92  THR B O     1 
ATOM   2827 C  CB    . THR B 1 83  ? -17.227 -15.623 -36.231 1.00 43.48  ? 92  THR B CB    1 
ATOM   2828 O  OG1   . THR B 1 83  ? -16.773 -15.972 -37.541 1.00 45.22  ? 92  THR B OG1   1 
ATOM   2829 C  CG2   . THR B 1 83  ? -18.730 -15.606 -36.155 1.00 46.64  ? 92  THR B CG2   1 
ATOM   2830 N  N     . GLN B 1 84  ? -14.489 -15.169 -35.176 1.00 41.37  ? 93  GLN B N     1 
ATOM   2831 C  CA    . GLN B 1 84  ? -13.059 -15.526 -35.349 1.00 47.05  ? 93  GLN B CA    1 
ATOM   2832 C  C     . GLN B 1 84  ? -12.851 -16.021 -36.804 1.00 42.27  ? 93  GLN B C     1 
ATOM   2833 O  O     . GLN B 1 84  ? -11.825 -15.715 -37.377 1.00 39.94  ? 93  GLN B O     1 
ATOM   2834 C  CB    . GLN B 1 84  ? -12.628 -16.509 -34.246 1.00 43.63  ? 93  GLN B CB    1 
ATOM   2835 C  CG    . GLN B 1 84  ? -12.553 -15.887 -32.850 1.00 53.63  ? 93  GLN B CG    1 
ATOM   2836 C  CD    . GLN B 1 84  ? -12.507 -16.920 -31.744 1.00 69.05  ? 93  GLN B CD    1 
ATOM   2837 O  OE1   . GLN B 1 84  ? -11.471 -17.520 -31.420 1.00 69.83  ? 93  GLN B OE1   1 
ATOM   2838 N  NE2   . GLN B 1 84  ? -13.665 -17.171 -31.164 1.00 78.45  ? 93  GLN B NE2   1 
ATOM   2839 N  N     . THR B 1 85  ? -13.787 -16.784 -37.390 1.00 45.55  ? 94  THR B N     1 
ATOM   2840 C  CA    . THR B 1 85  ? -13.615 -17.335 -38.762 1.00 41.51  ? 94  THR B CA    1 
ATOM   2841 C  C     . THR B 1 85  ? -13.592 -16.157 -39.749 1.00 38.94  ? 94  THR B C     1 
ATOM   2842 O  O     . THR B 1 85  ? -12.707 -16.128 -40.593 1.00 37.51  ? 94  THR B O     1 
ATOM   2843 C  CB    . THR B 1 85  ? -14.623 -18.442 -39.052 1.00 40.43  ? 94  THR B CB    1 
ATOM   2844 O  OG1   . THR B 1 85  ? -14.218 -19.582 -38.295 1.00 41.48  ? 94  THR B OG1   1 
ATOM   2845 C  CG2   . THR B 1 85  ? -14.704 -18.824 -40.509 1.00 44.88  ? 94  THR B CG2   1 
ATOM   2846 N  N     . HIS B 1 86  ? -14.453 -15.159 -39.568 1.00 42.20  ? 95  HIS B N     1 
ATOM   2847 C  CA    . HIS B 1 86  ? -14.507 -13.967 -40.448 1.00 43.57  ? 95  HIS B CA    1 
ATOM   2848 C  C     . HIS B 1 86  ? -13.150 -13.240 -40.446 1.00 44.87  ? 95  HIS B C     1 
ATOM   2849 O  O     . HIS B 1 86  ? -12.521 -13.070 -41.528 1.00 35.98  ? 95  HIS B O     1 
ATOM   2850 C  CB    . HIS B 1 86  ? -15.650 -13.063 -40.013 1.00 46.91  ? 95  HIS B CB    1 
ATOM   2851 C  CG    . HIS B 1 86  ? -16.998 -13.525 -40.437 1.00 46.53  ? 95  HIS B CG    1 
ATOM   2852 N  ND1   . HIS B 1 86  ? -17.874 -14.139 -39.558 1.00 47.06  ? 95  HIS B ND1   1 
ATOM   2853 C  CD2   . HIS B 1 86  ? -17.649 -13.403 -41.603 1.00 43.63  ? 95  HIS B CD2   1 
ATOM   2854 C  CE1   . HIS B 1 86  ? -19.005 -14.389 -40.175 1.00 46.72  ? 95  HIS B CE1   1 
ATOM   2855 N  NE2   . HIS B 1 86  ? -18.893 -13.946 -41.420 1.00 50.77  ? 95  HIS B NE2   1 
ATOM   2856 N  N     . MET B 1 87  ? -12.661 -12.916 -39.252 1.00 43.11  ? 96  MET B N     1 
ATOM   2857 C  CA    . MET B 1 87  ? -11.410 -12.147 -39.084 1.00 44.25  ? 96  MET B CA    1 
ATOM   2858 C  C     . MET B 1 87  ? -10.222 -12.977 -39.592 1.00 39.51  ? 96  MET B C     1 
ATOM   2859 O  O     . MET B 1 87  ? -9.294  -12.381 -40.200 1.00 41.51  ? 96  MET B O     1 
ATOM   2860 C  CB    . MET B 1 87  ? -11.227 -11.751 -37.616 1.00 48.27  ? 96  MET B CB    1 
ATOM   2861 C  CG    . MET B 1 87  ? -12.409 -10.961 -37.058 1.00 43.60  ? 96  MET B CG    1 
ATOM   2862 S  SD    . MET B 1 87  ? -12.967 -9.645  -38.174 1.00 49.40  ? 96  MET B SD    1 
ATOM   2863 C  CE    . MET B 1 87  ? -11.474 -8.695  -38.446 1.00 50.21  ? 96  MET B CE    1 
ATOM   2864 N  N     . ALA B 1 88  ? -10.245 -14.297 -39.434 1.00 35.36  ? 97  ALA B N     1 
ATOM   2865 C  CA    . ALA B 1 88  ? -9.181  -15.180 -39.973 1.00 36.59  ? 97  ALA B CA    1 
ATOM   2866 C  C     . ALA B 1 88  ? -9.108  -15.061 -41.506 1.00 37.29  ? 97  ALA B C     1 
ATOM   2867 O  O     . ALA B 1 88  ? -8.002  -14.913 -42.031 1.00 41.51  ? 97  ALA B O     1 
ATOM   2868 C  CB    . ALA B 1 88  ? -9.423  -16.593 -39.535 1.00 40.60  ? 97  ALA B CB    1 
ATOM   2869 N  N     . LEU B 1 89  ? -10.250 -15.089 -42.194 1.00 41.16  ? 98  LEU B N     1 
ATOM   2870 C  CA    . LEU B 1 89  ? -10.316 -14.960 -43.673 1.00 48.84  ? 98  LEU B CA    1 
ATOM   2871 C  C     . LEU B 1 89  ? -9.738  -13.601 -44.069 1.00 48.26  ? 98  LEU B C     1 
ATOM   2872 O  O     . LEU B 1 89  ? -9.032  -13.534 -45.096 1.00 52.51  ? 98  LEU B O     1 
ATOM   2873 C  CB    . LEU B 1 89  ? -11.757 -15.155 -44.164 1.00 47.76  ? 98  LEU B CB    1 
ATOM   2874 C  CG    . LEU B 1 89  ? -12.335 -16.533 -43.842 1.00 45.82  ? 98  LEU B CG    1 
ATOM   2875 C  CD1   . LEU B 1 89  ? -13.795 -16.645 -44.215 1.00 46.62  ? 98  LEU B CD1   1 
ATOM   2876 C  CD2   . LEU B 1 89  ? -11.547 -17.632 -44.526 1.00 54.00  ? 98  LEU B CD2   1 
ATOM   2877 N  N     . VAL B 1 90  ? -9.959  -12.571 -43.257 1.00 46.90  ? 99  VAL B N     1 
ATOM   2878 C  CA    . VAL B 1 90  ? -9.388  -11.220 -43.536 1.00 44.67  ? 99  VAL B CA    1 
ATOM   2879 C  C     . VAL B 1 90  ? -7.866  -11.345 -43.551 1.00 44.18  ? 99  VAL B C     1 
ATOM   2880 O  O     . VAL B 1 90  ? -7.216  -10.837 -44.484 1.00 49.68  ? 99  VAL B O     1 
ATOM   2881 C  CB    . VAL B 1 90  ? -9.873  -10.199 -42.503 1.00 43.88  ? 99  VAL B CB    1 
ATOM   2882 C  CG1   . VAL B 1 90  ? -9.034  -8.942  -42.473 1.00 40.55  ? 99  VAL B CG1   1 
ATOM   2883 C  CG2   . VAL B 1 90  ? -11.344 -9.887  -42.718 1.00 46.86  ? 99  VAL B CG2   1 
ATOM   2884 N  N     . GLN B 1 91  ? -7.323  -12.066 -42.583 1.00 43.52  ? 100 GLN B N     1 
ATOM   2885 C  CA    . GLN B 1 91  ? -5.858  -12.161 -42.389 1.00 44.06  ? 100 GLN B CA    1 
ATOM   2886 C  C     . GLN B 1 91  ? -5.241  -13.007 -43.497 1.00 41.81  ? 100 GLN B C     1 
ATOM   2887 O  O     . GLN B 1 91  ? -4.175  -12.633 -43.942 1.00 37.49  ? 100 GLN B O     1 
ATOM   2888 C  CB    . GLN B 1 91  ? -5.518  -12.744 -41.024 1.00 42.18  ? 100 GLN B CB    1 
ATOM   2889 C  CG    . GLN B 1 91  ? -4.029  -12.705 -40.743 1.00 46.81  ? 100 GLN B CG    1 
ATOM   2890 C  CD    . GLN B 1 91  ? -3.546  -11.308 -40.442 1.00 50.80  ? 100 GLN B CD    1 
ATOM   2891 O  OE1   . GLN B 1 91  ? -4.118  -10.305 -40.856 1.00 60.90  ? 100 GLN B OE1   1 
ATOM   2892 N  NE2   . GLN B 1 91  ? -2.463  -11.234 -39.707 1.00 60.33  ? 100 GLN B NE2   1 
ATOM   2893 N  N     . LEU B 1 92  ? -5.871  -14.130 -43.862 1.00 40.44  ? 101 LEU B N     1 
ATOM   2894 C  CA    . LEU B 1 92  ? -5.441  -14.989 -44.993 1.00 44.22  ? 101 LEU B CA    1 
ATOM   2895 C  C     . LEU B 1 92  ? -5.351  -14.193 -46.299 1.00 43.94  ? 101 LEU B C     1 
ATOM   2896 O  O     . LEU B 1 92  ? -4.415  -14.424 -47.051 1.00 55.62  ? 101 LEU B O     1 
ATOM   2897 C  CB    . LEU B 1 92  ? -6.421  -16.156 -45.127 1.00 46.71  ? 101 LEU B CB    1 
ATOM   2898 C  CG    . LEU B 1 92  ? -6.335  -17.170 -43.986 1.00 42.88  ? 101 LEU B CG    1 
ATOM   2899 C  CD1   . LEU B 1 92  ? -7.317  -18.296 -44.228 1.00 43.77  ? 101 LEU B CD1   1 
ATOM   2900 C  CD2   . LEU B 1 92  ? -4.922  -17.706 -43.852 1.00 41.32  ? 101 LEU B CD2   1 
ATOM   2901 N  N     . GLU B 1 93  ? -6.301  -13.316 -46.579 1.00 45.75  ? 102 GLU B N     1 
ATOM   2902 C  CA    . GLU B 1 93  ? -6.305  -12.508 -47.822 1.00 48.81  ? 102 GLU B CA    1 
ATOM   2903 C  C     . GLU B 1 93  ? -5.132  -11.537 -47.772 1.00 48.47  ? 102 GLU B C     1 
ATOM   2904 O  O     . GLU B 1 93  ? -4.490  -11.318 -48.826 1.00 48.28  ? 102 GLU B O     1 
ATOM   2905 C  CB    . GLU B 1 93  ? -7.606  -11.729 -47.979 1.00 49.57  ? 102 GLU B CB    1 
ATOM   2906 C  CG    . GLU B 1 93  ? -7.684  -10.943 -49.272 1.00 45.19  ? 102 GLU B CG    1 
ATOM   2907 C  CD    . GLU B 1 93  ? -6.850  -9.683  -49.386 1.00 43.54  ? 102 GLU B CD    1 
ATOM   2908 O  OE1   . GLU B 1 93  ? -6.673  -8.974  -48.386 1.00 44.68  ? 102 GLU B OE1   1 
ATOM   2909 O  OE2   . GLU B 1 93  ? -6.356  -9.417  -50.497 1.00 59.33  ? 102 GLU B OE2   1 
ATOM   2910 N  N     . ARG B 1 94  ? -4.890  -10.961 -46.596 1.00 44.42  ? 103 ARG B N     1 
ATOM   2911 C  CA    . ARG B 1 94  ? -3.898  -9.869  -46.422 1.00 44.80  ? 103 ARG B CA    1 
ATOM   2912 C  C     . ARG B 1 94  ? -2.477  -10.406 -46.507 1.00 36.72  ? 103 ARG B C     1 
ATOM   2913 O  O     . ARG B 1 94  ? -1.616  -9.617  -46.895 1.00 46.44  ? 103 ARG B O     1 
ATOM   2914 C  CB    . ARG B 1 94  ? -4.013  -9.150  -45.078 1.00 49.66  ? 103 ARG B CB    1 
ATOM   2915 C  CG    . ARG B 1 94  ? -5.103  -8.095  -45.005 1.00 48.27  ? 103 ARG B CG    1 
ATOM   2916 C  CD    . ARG B 1 94  ? -4.698  -7.093  -43.937 1.00 61.95  ? 103 ARG B CD    1 
ATOM   2917 N  NE    . ARG B 1 94  ? -5.801  -6.569  -43.141 1.00 63.17  ? 103 ARG B NE    1 
ATOM   2918 C  CZ    . ARG B 1 94  ? -5.871  -6.601  -41.816 1.00 68.38  ? 103 ARG B CZ    1 
ATOM   2919 N  NH1   . ARG B 1 94  ? -6.926  -6.086  -41.214 1.00 67.43  ? 103 ARG B NH1   1 
ATOM   2920 N  NH2   . ARG B 1 94  ? -4.903  -7.145  -41.091 1.00 78.51  ? 103 ARG B NH2   1 
ATOM   2921 N  N     . VAL B 1 95  ? -2.244  -11.682 -46.219 1.00 37.36  ? 104 VAL B N     1 
ATOM   2922 C  CA    . VAL B 1 95  ? -0.882  -12.295 -46.337 1.00 42.25  ? 104 VAL B CA    1 
ATOM   2923 C  C     . VAL B 1 95  ? -0.768  -13.162 -47.603 1.00 42.91  ? 104 VAL B C     1 
ATOM   2924 O  O     . VAL B 1 95  ? 0.275   -13.847 -47.733 1.00 47.66  ? 104 VAL B O     1 
ATOM   2925 C  CB    . VAL B 1 95  ? -0.484  -13.108 -45.087 1.00 40.66  ? 104 VAL B CB    1 
ATOM   2926 C  CG1   . VAL B 1 95  ? -0.663  -12.324 -43.801 1.00 44.03  ? 104 VAL B CG1   1 
ATOM   2927 C  CG2   . VAL B 1 95  ? -1.234  -14.422 -45.004 1.00 42.50  ? 104 VAL B CG2   1 
ATOM   2928 N  N     . GLY B 1 96  ? -1.779  -13.166 -48.477 1.00 49.52  ? 105 GLY B N     1 
ATOM   2929 C  CA    . GLY B 1 96  ? -1.732  -13.758 -49.830 1.00 45.05  ? 105 GLY B CA    1 
ATOM   2930 C  C     . GLY B 1 96  ? -1.956  -15.264 -49.870 1.00 50.41  ? 105 GLY B C     1 
ATOM   2931 O  O     . GLY B 1 96  ? -1.716  -15.849 -50.955 1.00 50.03  ? 105 GLY B O     1 
ATOM   2932 N  N     . LEU B 1 97  ? -2.469  -15.873 -48.793 1.00 43.88  ? 106 LEU B N     1 
ATOM   2933 C  CA    . LEU B 1 97  ? -2.813  -17.313 -48.750 1.00 48.83  ? 106 LEU B CA    1 
ATOM   2934 C  C     . LEU B 1 97  ? -4.258  -17.560 -49.190 1.00 48.18  ? 106 LEU B C     1 
ATOM   2935 O  O     . LEU B 1 97  ? -4.684  -18.710 -49.103 1.00 63.71  ? 106 LEU B O     1 
ATOM   2936 C  CB    . LEU B 1 97  ? -2.640  -17.804 -47.310 1.00 58.62  ? 106 LEU B CB    1 
ATOM   2937 C  CG    . LEU B 1 97  ? -1.220  -17.740 -46.770 1.00 62.95  ? 106 LEU B CG    1 
ATOM   2938 C  CD1   . LEU B 1 97  ? -1.196  -18.141 -45.302 1.00 64.45  ? 106 LEU B CD1   1 
ATOM   2939 C  CD2   . LEU B 1 97  ? -0.302  -18.628 -47.603 1.00 68.37  ? 106 LEU B CD2   1 
ATOM   2940 N  N     . LEU B 1 98  ? -5.013  -16.528 -49.538 1.00 47.93  ? 107 LEU B N     1 
ATOM   2941 C  CA    . LEU B 1 98  ? -6.432  -16.639 -49.979 1.00 49.01  ? 107 LEU B CA    1 
ATOM   2942 C  C     . LEU B 1 98  ? -6.618  -15.771 -51.230 1.00 45.64  ? 107 LEU B C     1 
ATOM   2943 O  O     . LEU B 1 98  ? -6.464  -14.555 -51.100 1.00 41.46  ? 107 LEU B O     1 
ATOM   2944 C  CB    . LEU B 1 98  ? -7.339  -16.175 -48.838 1.00 45.76  ? 107 LEU B CB    1 
ATOM   2945 C  CG    . LEU B 1 98  ? -8.838  -16.166 -49.130 1.00 53.08  ? 107 LEU B CG    1 
ATOM   2946 C  CD1   . LEU B 1 98  ? -9.624  -15.924 -47.855 1.00 54.62  ? 107 LEU B CD1   1 
ATOM   2947 C  CD2   . LEU B 1 98  ? -9.221  -15.113 -50.170 1.00 61.54  ? 107 LEU B CD2   1 
ATOM   2948 N  N     . ARG B 1 99  ? -6.900  -16.374 -52.391 1.00 47.29  ? 108 ARG B N     1 
ATOM   2949 C  CA    . ARG B 1 99  ? -6.947  -15.656 -53.700 1.00 51.45  ? 108 ARG B CA    1 
ATOM   2950 C  C     . ARG B 1 99  ? -8.329  -14.993 -53.862 1.00 49.24  ? 108 ARG B C     1 
ATOM   2951 O  O     . ARG B 1 99  ? -8.380  -13.811 -54.139 1.00 50.39  ? 108 ARG B O     1 
ATOM   2952 C  CB    . ARG B 1 99  ? -6.595  -16.617 -54.840 1.00 61.67  ? 108 ARG B CB    1 
ATOM   2953 C  CG    . ARG B 1 99  ? -6.849  -16.077 -56.244 1.00 71.57  ? 108 ARG B CG    1 
ATOM   2954 C  CD    . ARG B 1 99  ? -5.901  -14.976 -56.703 1.00 78.51  ? 108 ARG B CD    1 
ATOM   2955 N  NE    . ARG B 1 99  ? -5.808  -14.916 -58.165 1.00 92.32  ? 108 ARG B NE    1 
ATOM   2956 C  CZ    . ARG B 1 99  ? -5.059  -14.055 -58.857 1.00 96.07  ? 108 ARG B CZ    1 
ATOM   2957 N  NH1   . ARG B 1 99  ? -4.315  -13.160 -58.229 1.00 103.47 ? 108 ARG B NH1   1 
ATOM   2958 N  NH2   . ARG B 1 99  ? -5.056  -14.091 -60.179 1.00 86.06  ? 108 ARG B NH2   1 
ATOM   2959 N  N     . PHE B 1 100 ? -9.413  -15.732 -53.649 1.00 44.51  ? 109 PHE B N     1 
ATOM   2960 C  CA    . PHE B 1 100 ? -10.810 -15.238 -53.751 1.00 46.38  ? 109 PHE B CA    1 
ATOM   2961 C  C     . PHE B 1 100 ? -11.644 -15.808 -52.602 1.00 46.50  ? 109 PHE B C     1 
ATOM   2962 O  O     . PHE B 1 100 ? -11.282 -16.822 -51.961 1.00 44.92  ? 109 PHE B O     1 
ATOM   2963 C  CB    . PHE B 1 100 ? -11.457 -15.609 -55.095 1.00 45.34  ? 109 PHE B CB    1 
ATOM   2964 C  CG    . PHE B 1 100 ? -12.621 -14.729 -55.485 1.00 40.30  ? 109 PHE B CG    1 
ATOM   2965 C  CD1   . PHE B 1 100 ? -12.412 -13.450 -55.964 1.00 44.01  ? 109 PHE B CD1   1 
ATOM   2966 C  CD2   . PHE B 1 100 ? -13.924 -15.185 -55.361 1.00 47.49  ? 109 PHE B CD2   1 
ATOM   2967 C  CE1   . PHE B 1 100 ? -13.483 -12.633 -56.282 1.00 47.15  ? 109 PHE B CE1   1 
ATOM   2968 C  CE2   . PHE B 1 100 ? -14.995 -14.374 -55.678 1.00 47.11  ? 109 PHE B CE2   1 
ATOM   2969 C  CZ    . PHE B 1 100 ? -14.770 -13.102 -56.154 1.00 52.30  ? 109 PHE B CZ    1 
ATOM   2970 N  N     . LEU B 1 101 ? -12.776 -15.165 -52.361 1.00 41.11  ? 110 LEU B N     1 
ATOM   2971 C  CA    . LEU B 1 101 ? -13.733 -15.629 -51.344 1.00 44.58  ? 110 LEU B CA    1 
ATOM   2972 C  C     . LEU B 1 101 ? -15.115 -15.521 -51.978 1.00 43.73  ? 110 LEU B C     1 
ATOM   2973 O  O     . LEU B 1 101 ? -15.426 -14.446 -52.509 1.00 41.68  ? 110 LEU B O     1 
ATOM   2974 C  CB    . LEU B 1 101 ? -13.601 -14.764 -50.080 1.00 42.61  ? 110 LEU B CB    1 
ATOM   2975 C  CG    . LEU B 1 101 ? -14.717 -14.947 -49.051 1.00 43.56  ? 110 LEU B CG    1 
ATOM   2976 C  CD1   . LEU B 1 101 ? -14.862 -16.412 -48.684 1.00 44.44  ? 110 LEU B CD1   1 
ATOM   2977 C  CD2   . LEU B 1 101 ? -14.468 -14.114 -47.802 1.00 47.68  ? 110 LEU B CD2   1 
ATOM   2978 N  N     . VAL B 1 102 ? -15.880 -16.598 -51.886 1.00 40.94  ? 111 VAL B N     1 
ATOM   2979 C  CA    . VAL B 1 102 ? -17.267 -16.713 -52.395 1.00 44.52  ? 111 VAL B CA    1 
ATOM   2980 C  C     . VAL B 1 102 ? -18.211 -17.052 -51.250 1.00 41.72  ? 111 VAL B C     1 
ATOM   2981 O  O     . VAL B 1 102 ? -18.003 -18.114 -50.641 1.00 45.21  ? 111 VAL B O     1 
ATOM   2982 C  CB    . VAL B 1 102 ? -17.302 -17.830 -53.436 1.00 45.01  ? 111 VAL B CB    1 
ATOM   2983 C  CG1   . VAL B 1 102 ? -18.714 -18.029 -53.951 1.00 49.43  ? 111 VAL B CG1   1 
ATOM   2984 C  CG2   . VAL B 1 102 ? -16.307 -17.540 -54.542 1.00 50.87  ? 111 VAL B CG2   1 
ATOM   2985 N  N     . SER B 1 103 ? -19.211 -16.214 -50.997 1.00 42.78  ? 112 SER B N     1 
ATOM   2986 C  CA    . SER B 1 103 ? -20.157 -16.364 -49.855 1.00 46.34  ? 112 SER B CA    1 
ATOM   2987 C  C     . SER B 1 103 ? -21.605 -16.360 -50.335 1.00 47.06  ? 112 SER B C     1 
ATOM   2988 O  O     . SER B 1 103 ? -21.892 -15.627 -51.274 1.00 44.13  ? 112 SER B O     1 
ATOM   2989 C  CB    . SER B 1 103 ? -19.974 -15.307 -48.801 1.00 44.27  ? 112 SER B CB    1 
ATOM   2990 O  OG    . SER B 1 103 ? -20.535 -15.748 -47.564 1.00 43.33  ? 112 SER B OG    1 
ATOM   2991 N  N     . GLN B 1 104 ? -22.466 -17.136 -49.661 1.00 50.07  ? 113 GLN B N     1 
ATOM   2992 C  CA    . GLN B 1 104 ? -23.919 -17.220 -49.940 1.00 46.87  ? 113 GLN B CA    1 
ATOM   2993 C  C     . GLN B 1 104 ? -24.645 -16.330 -48.949 1.00 44.93  ? 113 GLN B C     1 
ATOM   2994 O  O     . GLN B 1 104 ? -25.834 -16.100 -49.123 1.00 48.49  ? 113 GLN B O     1 
ATOM   2995 C  CB    . GLN B 1 104 ? -24.403 -18.667 -49.886 1.00 55.52  ? 113 GLN B CB    1 
ATOM   2996 C  CG    . GLN B 1 104 ? -24.325 -19.367 -51.238 1.00 57.92  ? 113 GLN B CG    1 
ATOM   2997 C  CD    . GLN B 1 104 ? -24.463 -20.866 -51.136 1.00 59.88  ? 113 GLN B CD    1 
ATOM   2998 O  OE1   . GLN B 1 104 ? -25.533 -21.442 -51.369 1.00 65.38  ? 113 GLN B OE1   1 
ATOM   2999 N  NE2   . GLN B 1 104 ? -23.362 -21.513 -50.791 1.00 63.26  ? 113 GLN B NE2   1 
ATOM   3000 N  N     . ASN B 1 105 ? -23.933 -15.808 -47.955 1.00 48.13  ? 114 ASN B N     1 
ATOM   3001 C  CA    . ASN B 1 105 ? -24.589 -15.137 -46.809 1.00 40.56  ? 114 ASN B CA    1 
ATOM   3002 C  C     . ASN B 1 105 ? -25.007 -13.749 -47.235 1.00 39.83  ? 114 ASN B C     1 
ATOM   3003 O  O     . ASN B 1 105 ? -24.206 -13.062 -47.901 1.00 44.16  ? 114 ASN B O     1 
ATOM   3004 C  CB    . ASN B 1 105 ? -23.660 -15.026 -45.600 1.00 44.34  ? 114 ASN B CB    1 
ATOM   3005 C  CG    . ASN B 1 105 ? -23.076 -16.369 -45.259 1.00 43.54  ? 114 ASN B CG    1 
ATOM   3006 O  OD1   . ASN B 1 105 ? -23.580 -17.380 -45.737 1.00 42.96  ? 114 ASN B OD1   1 
ATOM   3007 N  ND2   . ASN B 1 105 ? -22.022 -16.388 -44.469 1.00 43.80  ? 114 ASN B ND2   1 
ATOM   3008 N  N     . VAL B 1 106 ? -26.150 -13.307 -46.740 1.00 42.44  ? 115 VAL B N     1 
ATOM   3009 C  CA    . VAL B 1 106 ? -26.697 -11.964 -47.062 1.00 43.25  ? 115 VAL B CA    1 
ATOM   3010 C  C     . VAL B 1 106 ? -26.502 -11.011 -45.876 1.00 46.32  ? 115 VAL B C     1 
ATOM   3011 O  O     . VAL B 1 106 ? -26.877 -9.841  -46.003 1.00 45.90  ? 115 VAL B O     1 
ATOM   3012 C  CB    . VAL B 1 106 ? -28.145 -12.150 -47.509 1.00 48.13  ? 115 VAL B CB    1 
ATOM   3013 C  CG1   . VAL B 1 106 ? -28.171 -12.839 -48.868 1.00 47.34  ? 115 VAL B CG1   1 
ATOM   3014 C  CG2   . VAL B 1 106 ? -28.979 -12.922 -46.498 1.00 48.12  ? 115 VAL B CG2   1 
ATOM   3015 N  N     . ASP B 1 107 ? -25.785 -11.475 -44.844 1.00 47.84  ? 116 ASP B N     1 
ATOM   3016 C  CA    . ASP B 1 107 ? -25.680 -10.863 -43.490 1.00 51.11  ? 116 ASP B CA    1 
ATOM   3017 C  C     . ASP B 1 107 ? -24.694 -9.678  -43.437 1.00 44.85  ? 116 ASP B C     1 
ATOM   3018 O  O     . ASP B 1 107 ? -24.705 -8.985  -42.425 1.00 62.63  ? 116 ASP B O     1 
ATOM   3019 C  CB    . ASP B 1 107 ? -25.282 -11.917 -42.453 1.00 50.88  ? 116 ASP B CB    1 
ATOM   3020 C  CG    . ASP B 1 107 ? -23.875 -12.465 -42.634 1.00 51.72  ? 116 ASP B CG    1 
ATOM   3021 O  OD1   . ASP B 1 107 ? -22.963 -11.688 -43.076 1.00 58.99  ? 116 ASP B OD1   1 
ATOM   3022 O  OD2   . ASP B 1 107 ? -23.687 -13.650 -42.326 1.00 44.21  ? 116 ASP B OD2   1 
ATOM   3023 N  N     . GLY B 1 108 ? -23.858 -9.473  -44.451 1.00 42.89  ? 117 GLY B N     1 
ATOM   3024 C  CA    . GLY B 1 108 ? -23.006 -8.279  -44.634 1.00 39.64  ? 117 GLY B CA    1 
ATOM   3025 C  C     . GLY B 1 108 ? -21.722 -8.312  -43.820 1.00 39.39  ? 117 GLY B C     1 
ATOM   3026 O  O     . GLY B 1 108 ? -20.973 -7.335  -43.871 1.00 50.38  ? 117 GLY B O     1 
ATOM   3027 N  N     . LEU B 1 109 ? -21.434 -9.402  -43.116 1.00 45.99  ? 118 LEU B N     1 
ATOM   3028 C  CA    . LEU B 1 109 ? -20.326 -9.465  -42.114 1.00 44.83  ? 118 LEU B CA    1 
ATOM   3029 C  C     . LEU B 1 109 ? -18.949 -9.529  -42.793 1.00 42.62  ? 118 LEU B C     1 
ATOM   3030 O  O     . LEU B 1 109 ? -17.996 -8.956  -42.235 1.00 47.35  ? 118 LEU B O     1 
ATOM   3031 C  CB    . LEU B 1 109 ? -20.572 -10.653 -41.181 1.00 45.03  ? 118 LEU B CB    1 
ATOM   3032 C  CG    . LEU B 1 109 ? -21.727 -10.474 -40.184 1.00 44.47  ? 118 LEU B CG    1 
ATOM   3033 C  CD1   . LEU B 1 109 ? -21.830 -11.664 -39.255 1.00 46.19  ? 118 LEU B CD1   1 
ATOM   3034 C  CD2   . LEU B 1 109 ? -21.578 -9.195  -39.371 1.00 43.37  ? 118 LEU B CD2   1 
ATOM   3035 N  N     . HIS B 1 110 ? -18.839 -10.182 -43.951 1.00 39.05  ? 119 HIS B N     1 
ATOM   3036 C  CA    . HIS B 1 110 ? -17.611 -10.184 -44.774 1.00 42.82  ? 119 HIS B CA    1 
ATOM   3037 C  C     . HIS B 1 110 ? -17.232 -8.733  -45.033 1.00 43.06  ? 119 HIS B C     1 
ATOM   3038 O  O     . HIS B 1 110 ? -16.156 -8.315  -44.618 1.00 49.91  ? 119 HIS B O     1 
ATOM   3039 C  CB    . HIS B 1 110 ? -17.803 -10.971 -46.068 1.00 46.54  ? 119 HIS B CB    1 
ATOM   3040 C  CG    . HIS B 1 110 ? -17.695 -12.435 -45.854 1.00 44.52  ? 119 HIS B CG    1 
ATOM   3041 N  ND1   . HIS B 1 110 ? -16.737 -12.971 -45.037 1.00 45.87  ? 119 HIS B ND1   1 
ATOM   3042 C  CD2   . HIS B 1 110 ? -18.422 -13.463 -46.334 1.00 47.98  ? 119 HIS B CD2   1 
ATOM   3043 C  CE1   . HIS B 1 110 ? -16.854 -14.281 -45.033 1.00 45.55  ? 119 HIS B CE1   1 
ATOM   3044 N  NE2   . HIS B 1 110 ? -17.895 -14.606 -45.816 1.00 48.14  ? 119 HIS B NE2   1 
ATOM   3045 N  N     . VAL B 1 111 ? -18.134 -7.977  -45.639 1.00 46.64  ? 120 VAL B N     1 
ATOM   3046 C  CA    . VAL B 1 111 ? -17.851 -6.560  -45.978 1.00 45.86  ? 120 VAL B CA    1 
ATOM   3047 C  C     . VAL B 1 111 ? -17.551 -5.829  -44.677 1.00 44.63  ? 120 VAL B C     1 
ATOM   3048 O  O     . VAL B 1 111 ? -16.493 -5.192  -44.592 1.00 41.44  ? 120 VAL B O     1 
ATOM   3049 C  CB    . VAL B 1 111 ? -18.992 -5.905  -46.772 1.00 44.86  ? 120 VAL B CB    1 
ATOM   3050 C  CG1   . VAL B 1 111 ? -18.803 -4.416  -46.830 1.00 41.67  ? 120 VAL B CG1   1 
ATOM   3051 C  CG2   . VAL B 1 111 ? -19.106 -6.471  -48.188 1.00 44.15  ? 120 VAL B CG2   1 
ATOM   3052 N  N     . ARG B 1 112 ? -18.402 -5.975  -43.665 1.00 50.52  ? 121 ARG B N     1 
ATOM   3053 C  CA    . ARG B 1 112 ? -18.215 -5.203  -42.403 1.00 47.64  ? 121 ARG B CA    1 
ATOM   3054 C  C     . ARG B 1 112 ? -16.934 -5.591  -41.653 1.00 42.83  ? 121 ARG B C     1 
ATOM   3055 O  O     . ARG B 1 112 ? -16.416 -4.732  -40.935 1.00 43.58  ? 121 ARG B O     1 
ATOM   3056 C  CB    . ARG B 1 112 ? -19.423 -5.372  -41.502 1.00 51.65  ? 121 ARG B CB    1 
ATOM   3057 C  CG    . ARG B 1 112 ? -20.570 -4.468  -41.901 1.00 48.52  ? 121 ARG B CG    1 
ATOM   3058 C  CD    . ARG B 1 112 ? -21.855 -5.062  -41.392 1.00 49.54  ? 121 ARG B CD    1 
ATOM   3059 N  NE    . ARG B 1 112 ? -22.272 -4.563  -40.095 1.00 49.58  ? 121 ARG B NE    1 
ATOM   3060 C  CZ    . ARG B 1 112 ? -22.799 -3.369  -39.930 1.00 45.74  ? 121 ARG B CZ    1 
ATOM   3061 N  NH1   . ARG B 1 112 ? -22.858 -2.543  -40.958 1.00 47.46  ? 121 ARG B NH1   1 
ATOM   3062 N  NH2   . ARG B 1 112 ? -23.249 -2.991  -38.752 1.00 46.94  ? 121 ARG B NH2   1 
ATOM   3063 N  N     . SER B 1 113 ? -16.451 -6.827  -41.798 1.00 42.78  ? 122 SER B N     1 
ATOM   3064 C  CA    . SER B 1 113 ? -15.137 -7.287  -41.267 1.00 45.73  ? 122 SER B CA    1 
ATOM   3065 C  C     . SER B 1 113 ? -13.965 -6.533  -41.950 1.00 45.72  ? 122 SER B C     1 
ATOM   3066 O  O     . SER B 1 113 ? -12.782 -6.600  -41.482 1.00 40.14  ? 122 SER B O     1 
ATOM   3067 C  CB    . SER B 1 113 ? -14.996 -8.799  -41.446 1.00 42.72  ? 122 SER B CB    1 
ATOM   3068 O  OG    . SER B 1 113 ? -14.758 -9.124  -42.813 1.00 41.43  ? 122 SER B OG    1 
ATOM   3069 N  N     . GLY B 1 114 ? -14.228 -5.891  -43.080 1.00 41.54  ? 123 GLY B N     1 
ATOM   3070 C  CA    . GLY B 1 114 ? -13.192 -5.151  -43.807 1.00 43.32  ? 123 GLY B CA    1 
ATOM   3071 C  C     . GLY B 1 114 ? -12.542 -6.037  -44.847 1.00 42.02  ? 123 GLY B C     1 
ATOM   3072 O  O     . GLY B 1 114 ? -11.505 -5.669  -45.375 1.00 51.43  ? 123 GLY B O     1 
ATOM   3073 N  N     . PHE B 1 115 ? -13.139 -7.166  -45.170 1.00 48.26  ? 124 PHE B N     1 
ATOM   3074 C  CA    . PHE B 1 115 ? -12.698 -7.946  -46.351 1.00 53.16  ? 124 PHE B CA    1 
ATOM   3075 C  C     . PHE B 1 115 ? -12.811 -7.071  -47.597 1.00 45.25  ? 124 PHE B C     1 
ATOM   3076 O  O     . PHE B 1 115 ? -13.793 -6.348  -47.732 1.00 49.33  ? 124 PHE B O     1 
ATOM   3077 C  CB    . PHE B 1 115 ? -13.528 -9.209  -46.517 1.00 48.53  ? 124 PHE B CB    1 
ATOM   3078 C  CG    . PHE B 1 115 ? -12.746 -10.278 -47.215 1.00 49.98  ? 124 PHE B CG    1 
ATOM   3079 C  CD1   . PHE B 1 115 ? -11.860 -11.067 -46.498 1.00 44.36  ? 124 PHE B CD1   1 
ATOM   3080 C  CD2   . PHE B 1 115 ? -12.872 -10.462 -48.586 1.00 47.58  ? 124 PHE B CD2   1 
ATOM   3081 C  CE1   . PHE B 1 115 ? -11.162 -12.074 -47.143 1.00 50.70  ? 124 PHE B CE1   1 
ATOM   3082 C  CE2   . PHE B 1 115 ? -12.170 -11.468 -49.222 1.00 46.66  ? 124 PHE B CE2   1 
ATOM   3083 C  CZ    . PHE B 1 115 ? -11.330 -12.280 -48.496 1.00 49.15  ? 124 PHE B CZ    1 
ATOM   3084 N  N     . PRO B 1 116 ? -11.807 -7.071  -48.507 1.00 47.39  ? 125 PRO B N     1 
ATOM   3085 C  CA    . PRO B 1 116 ? -11.860 -6.266  -49.735 1.00 45.33  ? 125 PRO B CA    1 
ATOM   3086 C  C     . PRO B 1 116 ? -12.901 -6.738  -50.739 1.00 43.93  ? 125 PRO B C     1 
ATOM   3087 O  O     . PRO B 1 116 ? -12.778 -7.864  -51.173 1.00 41.69  ? 125 PRO B O     1 
ATOM   3088 C  CB    . PRO B 1 116 ? -10.513 -6.484  -50.430 1.00 46.91  ? 125 PRO B CB    1 
ATOM   3089 C  CG    . PRO B 1 116 ? -9.960  -7.758  -49.836 1.00 44.95  ? 125 PRO B CG    1 
ATOM   3090 C  CD    . PRO B 1 116 ? -10.549 -7.843  -48.430 1.00 46.88  ? 125 PRO B CD    1 
ATOM   3091 N  N     . ARG B 1 117 ? -13.836 -5.858  -51.106 1.00 48.05  ? 126 ARG B N     1 
ATOM   3092 C  CA    . ARG B 1 117 ? -14.994 -6.181  -51.984 1.00 49.24  ? 126 ARG B CA    1 
ATOM   3093 C  C     . ARG B 1 117 ? -14.545 -6.714  -53.354 1.00 54.99  ? 126 ARG B C     1 
ATOM   3094 O  O     . ARG B 1 117 ? -15.227 -7.601  -53.870 1.00 60.59  ? 126 ARG B O     1 
ATOM   3095 C  CB    . ARG B 1 117 ? -15.862 -4.940  -52.120 1.00 49.82  ? 126 ARG B CB    1 
ATOM   3096 C  CG    . ARG B 1 117 ? -16.516 -4.543  -50.807 1.00 48.55  ? 126 ARG B CG    1 
ATOM   3097 C  CD    . ARG B 1 117 ? -17.585 -3.535  -51.084 1.00 49.53  ? 126 ARG B CD    1 
ATOM   3098 N  NE    . ARG B 1 117 ? -18.702 -4.097  -51.820 1.00 54.97  ? 126 ARG B NE    1 
ATOM   3099 C  CZ    . ARG B 1 117 ? -19.583 -3.368  -52.486 1.00 52.62  ? 126 ARG B CZ    1 
ATOM   3100 N  NH1   . ARG B 1 117 ? -19.458 -2.059  -52.525 1.00 54.39  ? 126 ARG B NH1   1 
ATOM   3101 N  NH2   . ARG B 1 117 ? -20.574 -3.938  -53.131 1.00 50.20  ? 126 ARG B NH2   1 
ATOM   3102 N  N     . ASP B 1 118 ? -13.403 -6.275  -53.884 1.00 56.23  ? 127 ASP B N     1 
ATOM   3103 C  CA    . ASP B 1 118 ? -12.942 -6.707  -55.231 1.00 59.69  ? 127 ASP B CA    1 
ATOM   3104 C  C     . ASP B 1 118 ? -12.448 -8.158  -55.152 1.00 57.81  ? 127 ASP B C     1 
ATOM   3105 O  O     . ASP B 1 118 ? -12.018 -8.652  -56.198 1.00 64.66  ? 127 ASP B O     1 
ATOM   3106 C  CB    . ASP B 1 118 ? -11.916 -5.744  -55.862 1.00 55.68  ? 127 ASP B CB    1 
ATOM   3107 C  CG    . ASP B 1 118 ? -10.554 -5.640  -55.183 1.00 63.56  ? 127 ASP B CG    1 
ATOM   3108 O  OD1   . ASP B 1 118 ? -10.403 -6.157  -54.063 1.00 71.98  ? 127 ASP B OD1   1 
ATOM   3109 O  OD2   . ASP B 1 118 ? -9.655  -5.003  -55.762 1.00 60.91  ? 127 ASP B OD2   1 
ATOM   3110 N  N     . LYS B 1 119 ? -12.480 -8.813  -53.982 1.00 52.83  ? 128 LYS B N     1 
ATOM   3111 C  CA    . LYS B 1 119 ? -12.051 -10.243 -53.847 1.00 47.34  ? 128 LYS B CA    1 
ATOM   3112 C  C     . LYS B 1 119 ? -13.148 -11.133 -53.242 1.00 46.63  ? 128 LYS B C     1 
ATOM   3113 O  O     . LYS B 1 119 ? -12.859 -12.320 -52.973 1.00 48.12  ? 128 LYS B O     1 
ATOM   3114 C  CB    . LYS B 1 119 ? -10.765 -10.305 -53.038 1.00 53.17  ? 128 LYS B CB    1 
ATOM   3115 C  CG    . LYS B 1 119 ? -9.536  -9.732  -53.738 1.00 52.46  ? 128 LYS B CG    1 
ATOM   3116 C  CD    . LYS B 1 119 ? -8.279  -10.363 -53.189 1.00 57.14  ? 128 LYS B CD    1 
ATOM   3117 C  CE    . LYS B 1 119 ? -7.005  -9.919  -53.871 1.00 63.22  ? 128 LYS B CE    1 
ATOM   3118 N  NZ    . LYS B 1 119 ? -5.861  -10.711 -53.385 1.00 59.33  ? 128 LYS B NZ    1 
ATOM   3119 N  N     . LEU B 1 120 ? -14.381 -10.611 -53.173 1.00 46.72  ? 129 LEU B N     1 
ATOM   3120 C  CA    . LEU B 1 120 ? -15.596 -11.253 -52.617 1.00 51.26  ? 129 LEU B CA    1 
ATOM   3121 C  C     . LEU B 1 120 ? -16.661 -11.364 -53.709 1.00 47.88  ? 129 LEU B C     1 
ATOM   3122 O  O     . LEU B 1 120 ? -16.927 -10.372 -54.332 1.00 43.73  ? 129 LEU B O     1 
ATOM   3123 C  CB    . LEU B 1 120 ? -16.089 -10.351 -51.483 1.00 55.22  ? 129 LEU B CB    1 
ATOM   3124 C  CG    . LEU B 1 120 ? -17.380 -10.756 -50.798 1.00 54.78  ? 129 LEU B CG    1 
ATOM   3125 C  CD1   . LEU B 1 120 ? -17.278 -12.149 -50.210 1.00 62.61  ? 129 LEU B CD1   1 
ATOM   3126 C  CD2   . LEU B 1 120 ? -17.719 -9.750  -49.727 1.00 56.97  ? 129 LEU B CD2   1 
ATOM   3127 N  N     . ALA B 1 121 ? -17.285 -12.525 -53.887 1.00 51.46  ? 130 ALA B N     1 
ATOM   3128 C  CA    . ALA B 1 121 ? -18.548 -12.668 -54.649 1.00 51.75  ? 130 ALA B CA    1 
ATOM   3129 C  C     . ALA B 1 121 ? -19.666 -12.892 -53.639 1.00 56.76  ? 130 ALA B C     1 
ATOM   3130 O  O     . ALA B 1 121 ? -19.620 -13.939 -52.980 1.00 60.59  ? 130 ALA B O     1 
ATOM   3131 C  CB    . ALA B 1 121 ? -18.470 -13.804 -55.645 1.00 48.94  ? 130 ALA B CB    1 
ATOM   3132 N  N     . GLU B 1 122 ? -20.583 -11.933 -53.476 1.00 52.78  ? 131 GLU B N     1 
ATOM   3133 C  CA    . GLU B 1 122 ? -21.789 -12.141 -52.634 1.00 53.51  ? 131 GLU B CA    1 
ATOM   3134 C  C     . GLU B 1 122 ? -22.872 -12.699 -53.561 1.00 53.18  ? 131 GLU B C     1 
ATOM   3135 O  O     . GLU B 1 122 ? -23.664 -11.921 -54.126 1.00 69.11  ? 131 GLU B O     1 
ATOM   3136 C  CB    . GLU B 1 122 ? -22.227 -10.872 -51.902 1.00 55.11  ? 131 GLU B CB    1 
ATOM   3137 C  CG    . GLU B 1 122 ? -21.082 -9.961  -51.514 1.00 56.61  ? 131 GLU B CG    1 
ATOM   3138 C  CD    . GLU B 1 122 ? -21.396 -9.075  -50.328 1.00 54.25  ? 131 GLU B CD    1 
ATOM   3139 O  OE1   . GLU B 1 122 ? -21.453 -7.852  -50.526 1.00 52.09  ? 131 GLU B OE1   1 
ATOM   3140 O  OE2   . GLU B 1 122 ? -21.577 -9.622  -49.211 1.00 50.47  ? 131 GLU B OE2   1 
ATOM   3141 N  N     . LEU B 1 123 ? -22.868 -14.014 -53.697 1.00 49.38  ? 132 LEU B N     1 
ATOM   3142 C  CA    . LEU B 1 123 ? -23.736 -14.806 -54.595 1.00 54.27  ? 132 LEU B CA    1 
ATOM   3143 C  C     . LEU B 1 123 ? -25.225 -14.513 -54.342 1.00 55.77  ? 132 LEU B C     1 
ATOM   3144 O  O     . LEU B 1 123 ? -25.968 -14.488 -55.344 1.00 51.07  ? 132 LEU B O     1 
ATOM   3145 C  CB    . LEU B 1 123 ? -23.382 -16.286 -54.396 1.00 50.13  ? 132 LEU B CB    1 
ATOM   3146 C  CG    . LEU B 1 123 ? -22.074 -16.731 -55.058 1.00 51.42  ? 132 LEU B CG    1 
ATOM   3147 C  CD1   . LEU B 1 123 ? -21.832 -18.232 -54.930 1.00 54.50  ? 132 LEU B CD1   1 
ATOM   3148 C  CD2   . LEU B 1 123 ? -22.050 -16.332 -56.518 1.00 54.75  ? 132 LEU B CD2   1 
ATOM   3149 N  N     . HIS B 1 124 ? -25.673 -14.299 -53.094 1.00 51.12  ? 133 HIS B N     1 
ATOM   3150 C  CA    . HIS B 1 124 ? -27.129 -14.155 -52.802 1.00 50.16  ? 133 HIS B CA    1 
ATOM   3151 C  C     . HIS B 1 124 ? -27.472 -12.718 -52.418 1.00 47.35  ? 133 HIS B C     1 
ATOM   3152 O  O     . HIS B 1 124 ? -28.670 -12.476 -52.176 1.00 48.95  ? 133 HIS B O     1 
ATOM   3153 C  CB    . HIS B 1 124 ? -27.633 -15.214 -51.799 1.00 51.30  ? 133 HIS B CB    1 
ATOM   3154 C  CG    . HIS B 1 124 ? -27.464 -16.610 -52.304 1.00 48.60  ? 133 HIS B CG    1 
ATOM   3155 N  ND1   . HIS B 1 124 ? -27.523 -17.701 -51.479 1.00 48.85  ? 133 HIS B ND1   1 
ATOM   3156 C  CD2   . HIS B 1 124 ? -27.175 -17.085 -53.543 1.00 51.75  ? 133 HIS B CD2   1 
ATOM   3157 C  CE1   . HIS B 1 124 ? -27.285 -18.797 -52.177 1.00 50.61  ? 133 HIS B CE1   1 
ATOM   3158 N  NE2   . HIS B 1 124 ? -27.073 -18.447 -53.449 1.00 53.99  ? 133 HIS B NE2   1 
ATOM   3159 N  N     . GLY B 1 125 ? -26.502 -11.797 -52.468 1.00 45.69  ? 134 GLY B N     1 
ATOM   3160 C  CA    . GLY B 1 125 ? -26.705 -10.367 -52.130 1.00 44.40  ? 134 GLY B CA    1 
ATOM   3161 C  C     . GLY B 1 125 ? -26.435 -10.055 -50.664 1.00 48.00  ? 134 GLY B C     1 
ATOM   3162 O  O     . GLY B 1 125 ? -25.867 -10.941 -49.964 1.00 41.66  ? 134 GLY B O     1 
ATOM   3163 N  N     . ASN B 1 126 ? -26.881 -8.874  -50.194 1.00 49.28  ? 135 ASN B N     1 
ATOM   3164 C  CA    . ASN B 1 126 ? -26.369 -8.211  -48.959 1.00 47.28  ? 135 ASN B CA    1 
ATOM   3165 C  C     . ASN B 1 126 ? -27.428 -7.263  -48.380 1.00 49.98  ? 135 ASN B C     1 
ATOM   3166 O  O     . ASN B 1 126 ? -27.744 -6.227  -48.996 1.00 52.64  ? 135 ASN B O     1 
ATOM   3167 C  CB    . ASN B 1 126 ? -25.027 -7.521  -49.234 1.00 49.62  ? 135 ASN B CB    1 
ATOM   3168 C  CG    . ASN B 1 126 ? -24.284 -7.005  -48.012 1.00 47.04  ? 135 ASN B CG    1 
ATOM   3169 O  OD1   . ASN B 1 126 ? -24.852 -6.717  -46.955 1.00 42.89  ? 135 ASN B OD1   1 
ATOM   3170 N  ND2   . ASN B 1 126 ? -22.998 -6.792  -48.192 1.00 46.31  ? 135 ASN B ND2   1 
ATOM   3171 N  N     . MET B 1 127 ? -27.929 -7.600  -47.187 1.00 54.96  ? 136 MET B N     1 
ATOM   3172 C  CA    . MET B 1 127 ? -28.934 -6.800  -46.450 1.00 48.64  ? 136 MET B CA    1 
ATOM   3173 C  C     . MET B 1 127 ? -28.557 -5.324  -46.506 1.00 45.25  ? 136 MET B C     1 
ATOM   3174 O  O     . MET B 1 127 ? -29.453 -4.499  -46.454 1.00 47.63  ? 136 MET B O     1 
ATOM   3175 C  CB    . MET B 1 127 ? -28.988 -7.208  -44.979 1.00 57.95  ? 136 MET B CB    1 
ATOM   3176 C  CG    . MET B 1 127 ? -30.369 -7.617  -44.546 1.00 64.42  ? 136 MET B CG    1 
ATOM   3177 S  SD    . MET B 1 127 ? -30.585 -9.313  -45.048 1.00 69.69  ? 136 MET B SD    1 
ATOM   3178 C  CE    . MET B 1 127 ? -29.805 -10.103 -43.639 1.00 77.85  ? 136 MET B CE    1 
ATOM   3179 N  N     . PHE B 1 128 ? -27.266 -5.014  -46.487 1.00 48.11  ? 137 PHE B N     1 
ATOM   3180 C  CA    . PHE B 1 128 ? -26.774 -3.634  -46.236 1.00 48.96  ? 137 PHE B CA    1 
ATOM   3181 C  C     . PHE B 1 128 ? -26.535 -2.884  -47.542 1.00 48.22  ? 137 PHE B C     1 
ATOM   3182 O  O     . PHE B 1 128 ? -26.244 -1.680  -47.437 1.00 55.82  ? 137 PHE B O     1 
ATOM   3183 C  CB    . PHE B 1 128 ? -25.489 -3.648  -45.407 1.00 48.19  ? 137 PHE B CB    1 
ATOM   3184 C  CG    . PHE B 1 128 ? -25.670 -4.215  -44.028 1.00 49.66  ? 137 PHE B CG    1 
ATOM   3185 C  CD1   . PHE B 1 128 ? -25.537 -5.577  -43.802 1.00 48.99  ? 137 PHE B CD1   1 
ATOM   3186 C  CD2   . PHE B 1 128 ? -25.990 -3.385  -42.965 1.00 52.42  ? 137 PHE B CD2   1 
ATOM   3187 C  CE1   . PHE B 1 128 ? -25.709 -6.094  -42.530 1.00 49.48  ? 137 PHE B CE1   1 
ATOM   3188 C  CE2   . PHE B 1 128 ? -26.160 -3.901  -41.692 1.00 51.49  ? 137 PHE B CE2   1 
ATOM   3189 C  CZ    . PHE B 1 128 ? -26.040 -5.258  -41.480 1.00 51.40  ? 137 PHE B CZ    1 
ATOM   3190 N  N     . VAL B 1 129 ? -26.680 -3.536  -48.702 1.00 51.30  ? 138 VAL B N     1 
ATOM   3191 C  CA    . VAL B 1 129 ? -26.308 -2.942  -50.024 1.00 53.00  ? 138 VAL B CA    1 
ATOM   3192 C  C     . VAL B 1 129 ? -27.558 -2.642  -50.876 1.00 57.43  ? 138 VAL B C     1 
ATOM   3193 O  O     . VAL B 1 129 ? -28.387 -3.551  -51.081 1.00 55.85  ? 138 VAL B O     1 
ATOM   3194 C  CB    . VAL B 1 129 ? -25.310 -3.866  -50.743 1.00 51.74  ? 138 VAL B CB    1 
ATOM   3195 C  CG1   . VAL B 1 129 ? -25.033 -3.457  -52.188 1.00 47.17  ? 138 VAL B CG1   1 
ATOM   3196 C  CG2   . VAL B 1 129 ? -24.018 -3.954  -49.955 1.00 51.21  ? 138 VAL B CG2   1 
ATOM   3197 N  N     . GLU B 1 130 ? -27.672 -1.397  -51.340 1.00 55.94  ? 139 GLU B N     1 
ATOM   3198 C  CA    . GLU B 1 130 ? -28.568 -0.938  -52.431 1.00 58.53  ? 139 GLU B CA    1 
ATOM   3199 C  C     . GLU B 1 130 ? -27.766 -0.781  -53.723 1.00 61.20  ? 139 GLU B C     1 
ATOM   3200 O  O     . GLU B 1 130 ? -26.621 -0.294  -53.637 1.00 54.72  ? 139 GLU B O     1 
ATOM   3201 C  CB    . GLU B 1 130 ? -29.122 0.451   -52.134 1.00 59.49  ? 139 GLU B CB    1 
ATOM   3202 C  CG    . GLU B 1 130 ? -30.271 0.431   -51.170 1.00 62.84  ? 139 GLU B CG    1 
ATOM   3203 C  CD    . GLU B 1 130 ? -30.510 1.731   -50.436 1.00 61.16  ? 139 GLU B CD    1 
ATOM   3204 O  OE1   . GLU B 1 130 ? -31.583 1.841   -49.853 1.00 71.36  ? 139 GLU B OE1   1 
ATOM   3205 O  OE2   . GLU B 1 130 ? -29.633 2.622   -50.447 1.00 62.28  ? 139 GLU B OE2   1 
ATOM   3206 N  N     . GLU B 1 131 ? -28.379 -1.106  -54.862 1.00 60.82  ? 140 GLU B N     1 
ATOM   3207 C  CA    . GLU B 1 131 ? -27.837 -0.876  -56.230 1.00 66.19  ? 140 GLU B CA    1 
ATOM   3208 C  C     . GLU B 1 131 ? -28.710 0.183   -56.903 1.00 70.48  ? 140 GLU B C     1 
ATOM   3209 O  O     . GLU B 1 131 ? -29.897 0.263   -56.555 1.00 68.74  ? 140 GLU B O     1 
ATOM   3210 C  CB    . GLU B 1 131 ? -27.854 -2.183  -57.028 1.00 67.19  ? 140 GLU B CB    1 
ATOM   3211 C  CG    . GLU B 1 131 ? -27.081 -2.106  -58.328 1.00 66.72  ? 140 GLU B CG    1 
ATOM   3212 C  CD    . GLU B 1 131 ? -26.654 -3.431  -58.939 1.00 65.87  ? 140 GLU B CD    1 
ATOM   3213 O  OE1   . GLU B 1 131 ? -26.395 -4.376  -58.193 1.00 62.38  ? 140 GLU B OE1   1 
ATOM   3214 O  OE2   . GLU B 1 131 ? -26.538 -3.495  -60.174 1.00 80.02  ? 140 GLU B OE2   1 
ATOM   3215 N  N     . CYS B 1 132 ? -28.158 0.956   -57.836 1.00 76.54  ? 141 CYS B N     1 
ATOM   3216 C  CA    . CYS B 1 132 ? -28.957 1.869   -58.692 1.00 78.73  ? 141 CYS B CA    1 
ATOM   3217 C  C     . CYS B 1 132 ? -29.469 1.101   -59.904 1.00 77.34  ? 141 CYS B C     1 
ATOM   3218 O  O     . CYS B 1 132 ? -28.654 0.544   -60.665 1.00 69.04  ? 141 CYS B O     1 
ATOM   3219 C  CB    . CYS B 1 132 ? -28.170 3.084   -59.154 1.00 84.13  ? 141 CYS B CB    1 
ATOM   3220 S  SG    . CYS B 1 132 ? -29.169 4.243   -60.123 1.00 96.50  ? 141 CYS B SG    1 
ATOM   3221 N  N     . ALA B 1 133 ? -30.778 1.139   -60.088 1.00 80.43  ? 142 ALA B N     1 
ATOM   3222 C  CA    . ALA B 1 133 ? -31.431 0.525   -61.252 1.00 93.83  ? 142 ALA B CA    1 
ATOM   3223 C  C     . ALA B 1 133 ? -30.958 1.260   -62.496 1.00 97.12  ? 142 ALA B C     1 
ATOM   3224 O  O     . ALA B 1 133 ? -31.079 0.711   -63.583 1.00 100.57 ? 142 ALA B O     1 
ATOM   3225 C  CB    . ALA B 1 133 ? -32.913 0.603   -61.099 1.00 94.35  ? 142 ALA B CB    1 
ATOM   3226 N  N     . LYS B 1 134 ? -30.423 2.463   -62.352 1.00 98.54  ? 143 LYS B N     1 
ATOM   3227 C  CA    . LYS B 1 134 ? -29.991 3.141   -63.589 1.00 97.46  ? 143 LYS B CA    1 
ATOM   3228 C  C     . LYS B 1 134 ? -28.501 2.896   -63.802 1.00 104.51 ? 143 LYS B C     1 
ATOM   3229 O  O     . LYS B 1 134 ? -28.186 2.064   -64.665 1.00 99.66  ? 143 LYS B O     1 
ATOM   3230 C  CB    . LYS B 1 134 ? -30.469 4.587   -63.630 1.00 97.06  ? 143 LYS B CB    1 
ATOM   3231 C  CG    . LYS B 1 134 ? -31.939 4.704   -64.036 1.00 109.74 ? 143 LYS B CG    1 
ATOM   3232 C  CD    . LYS B 1 134 ? -32.510 6.116   -64.193 1.00 115.32 ? 143 LYS B CD    1 
ATOM   3233 C  CE    . LYS B 1 134 ? -33.814 6.140   -64.981 1.00 109.80 ? 143 LYS B CE    1 
ATOM   3234 N  NZ    . LYS B 1 134 ? -34.433 7.488   -65.046 1.00 103.11 ? 143 LYS B NZ    1 
ATOM   3235 N  N     . CYS B 1 135 ? -27.616 3.453   -62.981 1.00 92.36  ? 144 CYS B N     1 
ATOM   3236 C  CA    . CYS B 1 135 ? -26.174 3.380   -63.319 1.00 84.05  ? 144 CYS B CA    1 
ATOM   3237 C  C     . CYS B 1 135 ? -25.455 2.208   -62.655 1.00 81.07  ? 144 CYS B C     1 
ATOM   3238 O  O     . CYS B 1 135 ? -24.227 2.214   -62.742 1.00 67.60  ? 144 CYS B O     1 
ATOM   3239 C  CB    . CYS B 1 135 ? -25.458 4.666   -62.956 1.00 92.73  ? 144 CYS B CB    1 
ATOM   3240 S  SG    . CYS B 1 135 ? -25.323 4.921   -61.170 1.00 89.83  ? 144 CYS B SG    1 
ATOM   3241 N  N     . LYS B 1 136 ? -26.168 1.294   -61.995 1.00 83.46  ? 145 LYS B N     1 
ATOM   3242 C  CA    . LYS B 1 136 ? -25.587 0.068   -61.387 1.00 83.59  ? 145 LYS B CA    1 
ATOM   3243 C  C     . LYS B 1 136 ? -24.602 0.431   -60.257 1.00 74.78  ? 145 LYS B C     1 
ATOM   3244 O  O     . LYS B 1 136 ? -23.820 -0.429  -59.871 1.00 77.18  ? 145 LYS B O     1 
ATOM   3245 C  CB    . LYS B 1 136 ? -25.085 -0.851  -62.513 1.00 93.72  ? 145 LYS B CB    1 
ATOM   3246 C  CG    . LYS B 1 136 ? -23.913 -1.779  -62.209 1.00 105.92 ? 145 LYS B CG    1 
ATOM   3247 C  CD    . LYS B 1 136 ? -23.576 -2.707  -63.366 1.00 109.76 ? 145 LYS B CD    1 
ATOM   3248 C  CE    . LYS B 1 136 ? -24.569 -3.843  -63.546 1.00 114.63 ? 145 LYS B CE    1 
ATOM   3249 N  NZ    . LYS B 1 136 ? -24.170 -4.783  -64.621 1.00 108.44 ? 145 LYS B NZ    1 
ATOM   3250 N  N     . THR B 1 137 ? -24.689 1.628   -59.684 1.00 72.68  ? 146 THR B N     1 
ATOM   3251 C  CA    . THR B 1 137 ? -23.825 2.023   -58.543 1.00 64.63  ? 146 THR B CA    1 
ATOM   3252 C  C     . THR B 1 137 ? -24.338 1.334   -57.268 1.00 61.12  ? 146 THR B C     1 
ATOM   3253 O  O     . THR B 1 137 ? -25.579 1.291   -57.049 1.00 53.51  ? 146 THR B O     1 
ATOM   3254 C  CB    . THR B 1 137 ? -23.709 3.549   -58.413 1.00 73.06  ? 146 THR B CB    1 
ATOM   3255 O  OG1   . THR B 1 137 ? -22.743 4.004   -59.363 1.00 72.60  ? 146 THR B OG1   1 
ATOM   3256 C  CG2   . THR B 1 137 ? -23.277 4.017   -57.039 1.00 77.26  ? 146 THR B CG2   1 
ATOM   3257 N  N     . GLN B 1 138 ? -23.411 0.820   -56.455 1.00 61.55  ? 147 GLN B N     1 
ATOM   3258 C  CA    . GLN B 1 138 ? -23.697 0.157   -55.151 1.00 60.20  ? 147 GLN B CA    1 
ATOM   3259 C  C     . GLN B 1 138 ? -23.398 1.096   -53.968 1.00 59.72  ? 147 GLN B C     1 
ATOM   3260 O  O     . GLN B 1 138 ? -22.307 1.658   -53.922 1.00 67.51  ? 147 GLN B O     1 
ATOM   3261 C  CB    . GLN B 1 138 ? -22.911 -1.150  -55.074 1.00 57.59  ? 147 GLN B CB    1 
ATOM   3262 C  CG    . GLN B 1 138 ? -23.676 -2.313  -55.683 1.00 53.46  ? 147 GLN B CG    1 
ATOM   3263 C  CD    . GLN B 1 138 ? -22.823 -3.541  -55.857 1.00 53.04  ? 147 GLN B CD    1 
ATOM   3264 O  OE1   . GLN B 1 138 ? -21.596 -3.498  -55.804 1.00 59.35  ? 147 GLN B OE1   1 
ATOM   3265 N  NE2   . GLN B 1 138 ? -23.480 -4.647  -56.114 1.00 53.77  ? 147 GLN B NE2   1 
ATOM   3266 N  N     . TYR B 1 139 ? -24.362 1.242   -53.058 1.00 57.91  ? 148 TYR B N     1 
ATOM   3267 C  CA    . TYR B 1 139 ? -24.246 1.926   -51.746 1.00 61.12  ? 148 TYR B CA    1 
ATOM   3268 C  C     . TYR B 1 139 ? -24.258 0.881   -50.625 1.00 54.51  ? 148 TYR B C     1 
ATOM   3269 O  O     . TYR B 1 139 ? -25.304 0.212   -50.409 1.00 53.16  ? 148 TYR B O     1 
ATOM   3270 C  CB    . TYR B 1 139 ? -25.404 2.911   -51.549 1.00 64.02  ? 148 TYR B CB    1 
ATOM   3271 C  CG    . TYR B 1 139 ? -25.483 3.972   -52.610 1.00 68.47  ? 148 TYR B CG    1 
ATOM   3272 C  CD1   . TYR B 1 139 ? -26.216 3.788   -53.774 1.00 73.41  ? 148 TYR B CD1   1 
ATOM   3273 C  CD2   . TYR B 1 139 ? -24.801 5.164   -52.451 1.00 70.67  ? 148 TYR B CD2   1 
ATOM   3274 C  CE1   . TYR B 1 139 ? -26.265 4.770   -54.753 1.00 74.75  ? 148 TYR B CE1   1 
ATOM   3275 C  CE2   . TYR B 1 139 ? -24.833 6.151   -53.419 1.00 71.94  ? 148 TYR B CE2   1 
ATOM   3276 C  CZ    . TYR B 1 139 ? -25.560 5.951   -54.577 1.00 73.27  ? 148 TYR B CZ    1 
ATOM   3277 O  OH    . TYR B 1 139 ? -25.578 6.950   -55.498 1.00 63.22  ? 148 TYR B OH    1 
ATOM   3278 N  N     . VAL B 1 140 ? -23.141 0.760   -49.908 1.00 52.25  ? 149 VAL B N     1 
ATOM   3279 C  CA    . VAL B 1 140 ? -23.031 -0.047  -48.658 1.00 46.34  ? 149 VAL B CA    1 
ATOM   3280 C  C     . VAL B 1 140 ? -23.449 0.852   -47.495 1.00 43.19  ? 149 VAL B C     1 
ATOM   3281 O  O     . VAL B 1 140 ? -22.661 1.754   -47.183 1.00 48.20  ? 149 VAL B O     1 
ATOM   3282 C  CB    . VAL B 1 140 ? -21.611 -0.610  -48.469 1.00 50.87  ? 149 VAL B CB    1 
ATOM   3283 C  CG1   . VAL B 1 140 ? -21.531 -1.605  -47.306 1.00 52.20  ? 149 VAL B CG1   1 
ATOM   3284 C  CG2   . VAL B 1 140 ? -21.087 -1.243  -49.742 1.00 42.98  ? 149 VAL B CG2   1 
ATOM   3285 N  N     . ARG B 1 141 ? -24.637 0.610   -46.909 1.00 40.78  ? 150 ARG B N     1 
ATOM   3286 C  CA    . ARG B 1 141 ? -25.261 1.422   -45.823 1.00 45.28  ? 150 ARG B CA    1 
ATOM   3287 C  C     . ARG B 1 141 ? -24.903 0.892   -44.413 1.00 47.13  ? 150 ARG B C     1 
ATOM   3288 O  O     . ARG B 1 141 ? -24.339 -0.196  -44.282 1.00 46.73  ? 150 ARG B O     1 
ATOM   3289 C  CB    . ARG B 1 141 ? -26.796 1.458   -45.971 1.00 49.59  ? 150 ARG B CB    1 
ATOM   3290 C  CG    . ARG B 1 141 ? -27.302 1.876   -47.347 1.00 49.47  ? 150 ARG B CG    1 
ATOM   3291 C  CD    . ARG B 1 141 ? -27.019 3.346   -47.558 1.00 55.01  ? 150 ARG B CD    1 
ATOM   3292 N  NE    . ARG B 1 141 ? -27.440 3.844   -48.850 1.00 59.78  ? 150 ARG B NE    1 
ATOM   3293 C  CZ    . ARG B 1 141 ? -27.297 5.104   -49.246 1.00 63.60  ? 150 ARG B CZ    1 
ATOM   3294 N  NH1   . ARG B 1 141 ? -26.756 6.005   -48.436 1.00 59.84  ? 150 ARG B NH1   1 
ATOM   3295 N  NH2   . ARG B 1 141 ? -27.704 5.449   -50.455 1.00 61.91  ? 150 ARG B NH2   1 
ATOM   3296 N  N     . ASP B 1 142 ? -25.246 1.645   -43.362 1.00 46.25  ? 151 ASP B N     1 
ATOM   3297 C  CA    . ASP B 1 142 ? -24.852 1.296   -41.978 1.00 48.75  ? 151 ASP B CA    1 
ATOM   3298 C  C     . ASP B 1 142 ? -25.995 0.549   -41.287 1.00 50.82  ? 151 ASP B C     1 
ATOM   3299 O  O     . ASP B 1 142 ? -25.773 0.091   -40.152 1.00 50.93  ? 151 ASP B O     1 
ATOM   3300 C  CB    . ASP B 1 142 ? -24.414 2.543   -41.221 1.00 51.36  ? 151 ASP B CB    1 
ATOM   3301 C  CG    . ASP B 1 142 ? -25.511 3.559   -40.949 1.00 51.87  ? 151 ASP B CG    1 
ATOM   3302 O  OD1   . ASP B 1 142 ? -26.679 3.337   -41.356 1.00 56.93  ? 151 ASP B OD1   1 
ATOM   3303 O  OD2   . ASP B 1 142 ? -25.181 4.580   -40.334 1.00 54.00  ? 151 ASP B OD2   1 
ATOM   3304 N  N     . THR B 1 143 ? -27.174 0.481   -41.918 1.00 47.49  ? 152 THR B N     1 
ATOM   3305 C  CA    . THR B 1 143 ? -28.350 -0.292  -41.434 1.00 53.31  ? 152 THR B CA    1 
ATOM   3306 C  C     . THR B 1 143 ? -28.861 -1.161  -42.593 1.00 54.94  ? 152 THR B C     1 
ATOM   3307 O  O     . THR B 1 143 ? -28.447 -0.901  -43.743 1.00 56.67  ? 152 THR B O     1 
ATOM   3308 C  CB    . THR B 1 143 ? -29.374 0.652   -40.786 1.00 51.70  ? 152 THR B CB    1 
ATOM   3309 O  OG1   . THR B 1 143 ? -29.666 1.731   -41.664 1.00 53.77  ? 152 THR B OG1   1 
ATOM   3310 C  CG2   . THR B 1 143 ? -28.870 1.274   -39.508 1.00 48.64  ? 152 THR B CG2   1 
ATOM   3311 N  N     . VAL B 1 144 ? -29.670 -2.186  -42.304 1.00 60.10  ? 153 VAL B N     1 
ATOM   3312 C  CA    . VAL B 1 144 ? -30.267 -3.077  -43.348 1.00 62.96  ? 153 VAL B CA    1 
ATOM   3313 C  C     . VAL B 1 144 ? -31.310 -2.265  -44.115 1.00 60.19  ? 153 VAL B C     1 
ATOM   3314 O  O     . VAL B 1 144 ? -32.131 -1.616  -43.454 1.00 55.73  ? 153 VAL B O     1 
ATOM   3315 C  CB    . VAL B 1 144 ? -30.910 -4.345  -42.767 1.00 64.43  ? 153 VAL B CB    1 
ATOM   3316 C  CG1   . VAL B 1 144 ? -29.956 -5.105  -41.857 1.00 68.53  ? 153 VAL B CG1   1 
ATOM   3317 C  CG2   . VAL B 1 144 ? -32.227 -4.040  -42.066 1.00 64.35  ? 153 VAL B CG2   1 
ATOM   3318 N  N     . VAL B 1 145 ? -31.316 -2.381  -45.442 1.00 57.74  ? 154 VAL B N     1 
ATOM   3319 C  CA    . VAL B 1 145 ? -32.010 -1.440  -46.378 1.00 64.37  ? 154 VAL B CA    1 
ATOM   3320 C  C     . VAL B 1 145 ? -33.527 -1.390  -46.099 1.00 64.00  ? 154 VAL B C     1 
ATOM   3321 O  O     . VAL B 1 145 ? -34.087 -0.244  -45.992 1.00 60.50  ? 154 VAL B O     1 
ATOM   3322 C  CB    . VAL B 1 145 ? -31.676 -1.775  -47.842 1.00 56.62  ? 154 VAL B CB    1 
ATOM   3323 C  CG1   . VAL B 1 145 ? -30.199 -1.557  -48.100 1.00 57.82  ? 154 VAL B CG1   1 
ATOM   3324 C  CG2   . VAL B 1 145 ? -32.070 -3.185  -48.224 1.00 62.70  ? 154 VAL B CG2   1 
ATOM   3325 N  N     . GLY B 1 146 ? -34.187 -2.546  -45.976 1.00 61.16  ? 155 GLY B N     1 
ATOM   3326 C  CA    . GLY B 1 146 ? -35.607 -2.594  -45.584 1.00 62.12  ? 155 GLY B CA    1 
ATOM   3327 C  C     . GLY B 1 146 ? -36.426 -3.572  -46.403 1.00 63.04  ? 155 GLY B C     1 
ATOM   3328 O  O     . GLY B 1 146 ? -37.440 -4.059  -45.878 1.00 77.16  ? 155 GLY B O     1 
ATOM   3329 N  N     . THR B 1 147 ? -36.029 -3.835  -47.645 1.00 61.14  ? 156 THR B N     1 
ATOM   3330 C  CA    . THR B 1 147 ? -36.764 -4.721  -48.587 1.00 58.70  ? 156 THR B CA    1 
ATOM   3331 C  C     . THR B 1 147 ? -35.931 -5.974  -48.860 1.00 59.26  ? 156 THR B C     1 
ATOM   3332 O  O     . THR B 1 147 ? -34.726 -5.958  -48.540 1.00 73.00  ? 156 THR B O     1 
ATOM   3333 C  CB    . THR B 1 147 ? -37.114 -3.988  -49.887 1.00 57.52  ? 156 THR B CB    1 
ATOM   3334 O  OG1   . THR B 1 147 ? -36.055 -4.120  -50.829 1.00 64.92  ? 156 THR B OG1   1 
ATOM   3335 C  CG2   . THR B 1 147 ? -37.360 -2.511  -49.702 1.00 65.07  ? 156 THR B CG2   1 
ATOM   3336 N  N     . MET B 1 148 ? -36.566 -7.011  -49.414 1.00 61.00  ? 157 MET B N     1 
ATOM   3337 C  CA    . MET B 1 148 ? -35.922 -8.244  -49.956 1.00 66.17  ? 157 MET B CA    1 
ATOM   3338 C  C     . MET B 1 148 ? -36.609 -8.582  -51.279 1.00 63.23  ? 157 MET B C     1 
ATOM   3339 O  O     . MET B 1 148 ? -37.829 -8.385  -51.354 1.00 64.37  ? 157 MET B O     1 
ATOM   3340 C  CB    . MET B 1 148 ? -36.065 -9.425  -48.981 1.00 77.70  ? 157 MET B CB    1 
ATOM   3341 C  CG    . MET B 1 148 ? -35.870 -9.036  -47.499 1.00 88.89  ? 157 MET B CG    1 
ATOM   3342 S  SD    . MET B 1 148 ? -35.341 -10.377 -46.379 1.00 87.42  ? 157 MET B SD    1 
ATOM   3343 C  CE    . MET B 1 148 ? -36.765 -11.467 -46.459 1.00 91.33  ? 157 MET B CE    1 
ATOM   3344 N  N     . GLY B 1 149 ? -35.873 -9.043  -52.292 1.00 62.46  ? 158 GLY B N     1 
ATOM   3345 C  CA    . GLY B 1 149 ? -36.462 -9.477  -53.577 1.00 63.39  ? 158 GLY B CA    1 
ATOM   3346 C  C     . GLY B 1 149 ? -36.270 -8.497  -54.734 1.00 72.21  ? 158 GLY B C     1 
ATOM   3347 O  O     . GLY B 1 149 ? -36.979 -8.677  -55.770 1.00 71.87  ? 158 GLY B O     1 
ATOM   3348 N  N     . LEU B 1 150 ? -35.313 -7.563  -54.612 1.00 70.54  ? 159 LEU B N     1 
ATOM   3349 C  CA    . LEU B 1 150 ? -34.912 -6.549  -55.638 1.00 72.79  ? 159 LEU B CA    1 
ATOM   3350 C  C     . LEU B 1 150 ? -36.061 -5.559  -55.903 1.00 75.37  ? 159 LEU B C     1 
ATOM   3351 O  O     . LEU B 1 150 ? -36.317 -5.222  -57.086 1.00 60.95  ? 159 LEU B O     1 
ATOM   3352 C  CB    . LEU B 1 150 ? -34.468 -7.223  -56.946 1.00 68.83  ? 159 LEU B CB    1 
ATOM   3353 C  CG    . LEU B 1 150 ? -33.508 -8.410  -56.842 1.00 76.89  ? 159 LEU B CG    1 
ATOM   3354 C  CD1   . LEU B 1 150 ? -32.901 -8.725  -58.203 1.00 73.36  ? 159 LEU B CD1   1 
ATOM   3355 C  CD2   . LEU B 1 150 ? -32.394 -8.164  -55.837 1.00 85.56  ? 159 LEU B CD2   1 
ATOM   3356 N  N     . LYS B 1 151 ? -36.697 -5.067  -54.838 1.00 76.89  ? 160 LYS B N     1 
ATOM   3357 C  CA    . LYS B 1 151 ? -37.768 -4.039  -54.919 1.00 78.82  ? 160 LYS B CA    1 
ATOM   3358 C  C     . LYS B 1 151 ? -37.187 -2.698  -54.450 1.00 84.43  ? 160 LYS B C     1 
ATOM   3359 O  O     . LYS B 1 151 ? -36.069 -2.689  -53.913 1.00 80.68  ? 160 LYS B O     1 
ATOM   3360 C  CB    . LYS B 1 151 ? -38.995 -4.500  -54.127 1.00 82.12  ? 160 LYS B CB    1 
ATOM   3361 C  CG    . LYS B 1 151 ? -39.203 -6.014  -54.085 1.00 88.01  ? 160 LYS B CG    1 
ATOM   3362 C  CD    . LYS B 1 151 ? -40.605 -6.478  -54.437 1.00 94.09  ? 160 LYS B CD    1 
ATOM   3363 C  CE    . LYS B 1 151 ? -40.875 -7.921  -54.054 1.00 95.92  ? 160 LYS B CE    1 
ATOM   3364 N  NZ    . LYS B 1 151 ? -41.080 -8.081  -52.591 1.00 97.17  ? 160 LYS B NZ    1 
ATOM   3365 N  N     . ALA B 1 152 ? -37.934 -1.611  -54.663 1.00 89.49  ? 161 ALA B N     1 
ATOM   3366 C  CA    . ALA B 1 152 ? -37.509 -0.206  -54.453 1.00 74.49  ? 161 ALA B CA    1 
ATOM   3367 C  C     . ALA B 1 152 ? -37.439 0.136   -52.953 1.00 79.85  ? 161 ALA B C     1 
ATOM   3368 O  O     . ALA B 1 152 ? -38.436 -0.091  -52.225 1.00 71.73  ? 161 ALA B O     1 
ATOM   3369 C  CB    . ALA B 1 152 ? -38.460 0.717   -55.180 1.00 73.50  ? 161 ALA B CB    1 
ATOM   3370 N  N     . THR B 1 153 ? -36.316 0.723   -52.523 1.00 74.59  ? 162 THR B N     1 
ATOM   3371 C  CA    . THR B 1 153 ? -36.064 1.164   -51.127 1.00 72.35  ? 162 THR B CA    1 
ATOM   3372 C  C     . THR B 1 153 ? -36.745 2.528   -50.912 1.00 74.23  ? 162 THR B C     1 
ATOM   3373 O  O     . THR B 1 153 ? -37.139 2.830   -49.761 1.00 70.59  ? 162 THR B O     1 
ATOM   3374 C  CB    . THR B 1 153 ? -34.555 1.123   -50.827 1.00 73.08  ? 162 THR B CB    1 
ATOM   3375 O  OG1   . THR B 1 153 ? -33.817 2.025   -51.654 1.00 69.55  ? 162 THR B OG1   1 
ATOM   3376 C  CG2   . THR B 1 153 ? -33.954 -0.247  -51.044 1.00 69.04  ? 162 THR B CG2   1 
ATOM   3377 N  N     . GLY B 1 154 ? -36.910 3.319   -51.977 1.00 74.56  ? 163 GLY B N     1 
ATOM   3378 C  CA    . GLY B 1 154 ? -37.481 4.679   -51.909 1.00 69.18  ? 163 GLY B CA    1 
ATOM   3379 C  C     . GLY B 1 154 ? -36.402 5.727   -51.695 1.00 77.63  ? 163 GLY B C     1 
ATOM   3380 O  O     . GLY B 1 154 ? -36.758 6.919   -51.460 1.00 78.56  ? 163 GLY B O     1 
ATOM   3381 N  N     . ARG B 1 155 ? -35.129 5.315   -51.773 1.00 75.29  ? 164 ARG B N     1 
ATOM   3382 C  CA    . ARG B 1 155 ? -33.956 6.227   -51.862 1.00 70.20  ? 164 ARG B CA    1 
ATOM   3383 C  C     . ARG B 1 155 ? -33.493 6.295   -53.322 1.00 66.76  ? 164 ARG B C     1 
ATOM   3384 O  O     . ARG B 1 155 ? -33.709 5.307   -54.049 1.00 61.89  ? 164 ARG B O     1 
ATOM   3385 C  CB    . ARG B 1 155 ? -32.845 5.770   -50.914 1.00 72.76  ? 164 ARG B CB    1 
ATOM   3386 C  CG    . ARG B 1 155 ? -33.053 6.221   -49.477 1.00 73.15  ? 164 ARG B CG    1 
ATOM   3387 C  CD    . ARG B 1 155 ? -32.018 5.628   -48.541 1.00 72.83  ? 164 ARG B CD    1 
ATOM   3388 N  NE    . ARG B 1 155 ? -32.093 4.175   -48.460 1.00 70.62  ? 164 ARG B NE    1 
ATOM   3389 C  CZ    . ARG B 1 155 ? -33.064 3.506   -47.846 1.00 73.93  ? 164 ARG B CZ    1 
ATOM   3390 N  NH1   . ARG B 1 155 ? -34.057 4.168   -47.277 1.00 75.39  ? 164 ARG B NH1   1 
ATOM   3391 N  NH2   . ARG B 1 155 ? -33.042 2.182   -47.800 1.00 71.28  ? 164 ARG B NH2   1 
ATOM   3392 N  N     . LEU B 1 156 ? -32.891 7.429   -53.711 1.00 68.17  ? 165 LEU B N     1 
ATOM   3393 C  CA    . LEU B 1 156 ? -32.514 7.781   -55.110 1.00 73.42  ? 165 LEU B CA    1 
ATOM   3394 C  C     . LEU B 1 156 ? -30.993 7.957   -55.214 1.00 68.83  ? 165 LEU B C     1 
ATOM   3395 O  O     . LEU B 1 156 ? -30.390 8.453   -54.253 1.00 72.23  ? 165 LEU B O     1 
ATOM   3396 C  CB    . LEU B 1 156 ? -33.216 9.081   -55.537 1.00 84.20  ? 165 LEU B CB    1 
ATOM   3397 C  CG    . LEU B 1 156 ? -34.725 9.173   -55.289 1.00 89.44  ? 165 LEU B CG    1 
ATOM   3398 C  CD1   . LEU B 1 156 ? -35.035 10.102  -54.118 1.00 87.42  ? 165 LEU B CD1   1 
ATOM   3399 C  CD2   . LEU B 1 156 ? -35.453 9.656   -56.540 1.00 85.97  ? 165 LEU B CD2   1 
ATOM   3400 N  N     . CYS B 1 157 ? -30.417 7.597   -56.364 1.00 68.85  ? 166 CYS B N     1 
ATOM   3401 C  CA    . CYS B 1 157 ? -28.969 7.710   -56.687 1.00 75.67  ? 166 CYS B CA    1 
ATOM   3402 C  C     . CYS B 1 157 ? -28.499 9.162   -56.561 1.00 70.17  ? 166 CYS B C     1 
ATOM   3403 O  O     . CYS B 1 157 ? -29.327 10.063  -56.780 1.00 70.95  ? 166 CYS B O     1 
ATOM   3404 C  CB    . CYS B 1 157 ? -28.692 7.225   -58.104 1.00 80.70  ? 166 CYS B CB    1 
ATOM   3405 S  SG    . CYS B 1 157 ? -26.921 7.106   -58.459 1.00 99.05  ? 166 CYS B SG    1 
ATOM   3406 N  N     . THR B 1 158 ? -27.210 9.371   -56.284 1.00 71.79  ? 167 THR B N     1 
ATOM   3407 C  CA    . THR B 1 158 ? -26.633 10.699  -55.920 1.00 77.39  ? 167 THR B CA    1 
ATOM   3408 C  C     . THR B 1 158 ? -25.345 11.000  -56.706 1.00 77.34  ? 167 THR B C     1 
ATOM   3409 O  O     . THR B 1 158 ? -24.612 11.929  -56.293 1.00 75.93  ? 167 THR B O     1 
ATOM   3410 C  CB    . THR B 1 158 ? -26.418 10.780  -54.402 1.00 69.50  ? 167 THR B CB    1 
ATOM   3411 O  OG1   . THR B 1 158 ? -25.512 9.740   -54.027 1.00 74.11  ? 167 THR B OG1   1 
ATOM   3412 C  CG2   . THR B 1 158 ? -27.714 10.659  -53.629 1.00 61.68  ? 167 THR B CG2   1 
ATOM   3413 N  N     . VAL B 1 159 ? -25.114 10.312  -57.832 1.00 90.68  ? 168 VAL B N     1 
ATOM   3414 C  CA    . VAL B 1 159 ? -23.871 10.444  -58.661 1.00 88.65  ? 168 VAL B CA    1 
ATOM   3415 C  C     . VAL B 1 159 ? -24.026 11.678  -59.565 1.00 85.64  ? 168 VAL B C     1 
ATOM   3416 O  O     . VAL B 1 159 ? -25.169 11.987  -59.930 1.00 86.75  ? 168 VAL B O     1 
ATOM   3417 C  CB    . VAL B 1 159 ? -23.585 9.149   -59.454 1.00 84.16  ? 168 VAL B CB    1 
ATOM   3418 C  CG1   . VAL B 1 159 ? -22.291 9.229   -60.245 1.00 82.57  ? 168 VAL B CG1   1 
ATOM   3419 C  CG2   . VAL B 1 159 ? -23.559 7.920   -58.552 1.00 81.13  ? 168 VAL B CG2   1 
ATOM   3420 N  N     . ALA B 1 160 ? -22.916 12.360  -59.879 1.00 99.07  ? 169 ALA B N     1 
ATOM   3421 C  CA    . ALA B 1 160 ? -22.838 13.602  -60.693 1.00 99.42  ? 169 ALA B CA    1 
ATOM   3422 C  C     . ALA B 1 160 ? -21.372 14.051  -60.814 1.00 99.70  ? 169 ALA B C     1 
ATOM   3423 O  O     . ALA B 1 160 ? -21.132 15.181  -61.328 1.00 84.67  ? 169 ALA B O     1 
ATOM   3424 C  CB    . ALA B 1 160 ? -23.694 14.685  -60.076 1.00 94.58  ? 169 ALA B CB    1 
ATOM   3425 N  N     . CYS B 1 168 ? -28.559 12.050  -61.110 1.00 73.83  ? 177 CYS B N     1 
ATOM   3426 C  CA    . CYS B 1 168 ? -28.907 10.717  -61.677 1.00 76.59  ? 177 CYS B CA    1 
ATOM   3427 C  C     . CYS B 1 168 ? -30.313 10.289  -61.247 1.00 80.14  ? 177 CYS B C     1 
ATOM   3428 O  O     . CYS B 1 168 ? -31.085 9.849   -62.110 1.00 87.92  ? 177 CYS B O     1 
ATOM   3429 C  CB    . CYS B 1 168 ? -27.925 9.636   -61.241 1.00 84.87  ? 177 CYS B CB    1 
ATOM   3430 S  SG    . CYS B 1 168 ? -28.489 7.973   -61.685 1.00 92.86  ? 177 CYS B SG    1 
ATOM   3431 N  N     . ARG B 1 169 ? -30.593 10.329  -59.945 1.00 82.60  ? 178 ARG B N     1 
ATOM   3432 C  CA    . ARG B 1 169 ? -31.964 10.243  -59.381 1.00 82.12  ? 178 ARG B CA    1 
ATOM   3433 C  C     . ARG B 1 169 ? -32.664 8.955   -59.845 1.00 81.87  ? 178 ARG B C     1 
ATOM   3434 O  O     . ARG B 1 169 ? -33.888 9.001   -60.063 1.00 79.01  ? 178 ARG B O     1 
ATOM   3435 C  CB    . ARG B 1 169 ? -32.740 11.508  -59.782 1.00 83.80  ? 178 ARG B CB    1 
ATOM   3436 C  CG    . ARG B 1 169 ? -31.989 12.810  -59.523 1.00 84.16  ? 178 ARG B CG    1 
ATOM   3437 C  CD    . ARG B 1 169 ? -32.747 14.087  -59.867 1.00 85.30  ? 178 ARG B CD    1 
ATOM   3438 N  NE    . ARG B 1 169 ? -34.026 14.186  -59.177 1.00 86.36  ? 178 ARG B NE    1 
ATOM   3439 C  CZ    . ARG B 1 169 ? -34.192 14.466  -57.880 1.00 85.21  ? 178 ARG B CZ    1 
ATOM   3440 N  NH1   . ARG B 1 169 ? -33.157 14.678  -57.086 1.00 80.10  ? 178 ARG B NH1   1 
ATOM   3441 N  NH2   . ARG B 1 169 ? -35.412 14.508  -57.375 1.00 84.96  ? 178 ARG B NH2   1 
ATOM   3442 N  N     . GLY B 1 170 ? -31.933 7.841   -59.951 1.00 86.52  ? 179 GLY B N     1 
ATOM   3443 C  CA    . GLY B 1 170 ? -32.477 6.525   -60.354 1.00 85.70  ? 179 GLY B CA    1 
ATOM   3444 C  C     . GLY B 1 170 ? -33.061 5.778   -59.169 1.00 86.57  ? 179 GLY B C     1 
ATOM   3445 O  O     . GLY B 1 170 ? -32.806 6.200   -58.038 1.00 90.32  ? 179 GLY B O     1 
ATOM   3446 N  N     . GLU B 1 171 ? -33.821 4.704   -59.396 1.00 80.53  ? 180 GLU B N     1 
ATOM   3447 C  CA    . GLU B 1 171 ? -34.462 3.942   -58.289 1.00 81.38  ? 180 GLU B CA    1 
ATOM   3448 C  C     . GLU B 1 171 ? -33.434 2.956   -57.699 1.00 86.33  ? 180 GLU B C     1 
ATOM   3449 O  O     . GLU B 1 171 ? -32.974 2.054   -58.436 1.00 79.54  ? 180 GLU B O     1 
ATOM   3450 C  CB    . GLU B 1 171 ? -35.772 3.325   -58.783 1.00 78.98  ? 180 GLU B CB    1 
ATOM   3451 C  CG    . GLU B 1 171 ? -36.069 1.928   -58.262 1.00 82.53  ? 180 GLU B CG    1 
ATOM   3452 C  CD    . GLU B 1 171 ? -37.484 1.424   -58.536 1.00 80.57  ? 180 GLU B CD    1 
ATOM   3453 O  OE1   . GLU B 1 171 ? -37.688 0.187   -58.540 1.00 67.46  ? 180 GLU B OE1   1 
ATOM   3454 O  OE2   . GLU B 1 171 ? -38.384 2.267   -58.731 1.00 77.62  ? 180 GLU B OE2   1 
ATOM   3455 N  N     . LEU B 1 172 ? -33.089 3.140   -56.413 1.00 76.24  ? 181 LEU B N     1 
ATOM   3456 C  CA    . LEU B 1 172 ? -32.247 2.215   -55.604 1.00 65.42  ? 181 LEU B CA    1 
ATOM   3457 C  C     . LEU B 1 172 ? -33.100 1.031   -55.167 1.00 64.55  ? 181 LEU B C     1 
ATOM   3458 O  O     . LEU B 1 172 ? -34.189 1.270   -54.607 1.00 62.26  ? 181 LEU B O     1 
ATOM   3459 C  CB    . LEU B 1 172 ? -31.715 2.923   -54.355 1.00 67.30  ? 181 LEU B CB    1 
ATOM   3460 C  CG    . LEU B 1 172 ? -30.769 4.107   -54.570 1.00 66.17  ? 181 LEU B CG    1 
ATOM   3461 C  CD1   . LEU B 1 172 ? -30.128 4.496   -53.248 1.00 64.51  ? 181 LEU B CD1   1 
ATOM   3462 C  CD2   . LEU B 1 172 ? -29.696 3.805   -55.609 1.00 66.36  ? 181 LEU B CD2   1 
ATOM   3463 N  N     . ARG B 1 173 ? -32.625 -0.192  -55.387 1.00 62.79  ? 182 ARG B N     1 
ATOM   3464 C  CA    . ARG B 1 173 ? -33.352 -1.399  -54.925 1.00 65.80  ? 182 ARG B CA    1 
ATOM   3465 C  C     . ARG B 1 173 ? -32.439 -2.240  -54.039 1.00 67.62  ? 182 ARG B C     1 
ATOM   3466 O  O     . ARG B 1 173 ? -31.202 -2.086  -54.156 1.00 58.44  ? 182 ARG B O     1 
ATOM   3467 C  CB    . ARG B 1 173 ? -33.810 -2.242  -56.112 1.00 71.57  ? 182 ARG B CB    1 
ATOM   3468 C  CG    . ARG B 1 173 ? -34.844 -1.559  -56.996 1.00 83.10  ? 182 ARG B CG    1 
ATOM   3469 C  CD    . ARG B 1 173 ? -35.057 -2.284  -58.316 1.00 80.41  ? 182 ARG B CD    1 
ATOM   3470 N  NE    . ARG B 1 173 ? -35.904 -1.526  -59.235 1.00 76.99  ? 182 ARG B NE    1 
ATOM   3471 C  CZ    . ARG B 1 173 ? -36.015 -1.759  -60.542 1.00 66.48  ? 182 ARG B CZ    1 
ATOM   3472 N  NH1   . ARG B 1 173 ? -35.337 -2.738  -61.113 1.00 60.08  ? 182 ARG B NH1   1 
ATOM   3473 N  NH2   . ARG B 1 173 ? -36.784 -0.988  -61.283 1.00 65.73  ? 182 ARG B NH2   1 
ATOM   3474 N  N     . ASP B 1 174 ? -33.042 -3.123  -53.233 1.00 68.56  ? 183 ASP B N     1 
ATOM   3475 C  CA    . ASP B 1 174 ? -32.338 -4.152  -52.421 1.00 66.72  ? 183 ASP B CA    1 
ATOM   3476 C  C     . ASP B 1 174 ? -31.573 -5.085  -53.369 1.00 67.19  ? 183 ASP B C     1 
ATOM   3477 O  O     . ASP B 1 174 ? -31.811 -5.028  -54.599 1.00 75.61  ? 183 ASP B O     1 
ATOM   3478 C  CB    . ASP B 1 174 ? -33.312 -4.934  -51.529 1.00 69.73  ? 183 ASP B CB    1 
ATOM   3479 C  CG    . ASP B 1 174 ? -34.117 -6.009  -52.243 1.00 66.87  ? 183 ASP B CG    1 
ATOM   3480 O  OD1   . ASP B 1 174 ? -33.504 -7.044  -52.595 1.00 63.24  ? 183 ASP B OD1   1 
ATOM   3481 O  OD2   . ASP B 1 174 ? -35.361 -5.811  -52.444 1.00 64.99  ? 183 ASP B OD2   1 
ATOM   3482 N  N     . THR B 1 175 ? -30.689 -5.913  -52.821 1.00 58.21  ? 184 THR B N     1 
ATOM   3483 C  CA    . THR B 1 175 ? -29.847 -6.851  -53.599 1.00 57.03  ? 184 THR B CA    1 
ATOM   3484 C  C     . THR B 1 175 ? -30.110 -8.297  -53.144 1.00 49.02  ? 184 THR B C     1 
ATOM   3485 O  O     . THR B 1 175 ? -29.378 -9.175  -53.552 1.00 47.70  ? 184 THR B O     1 
ATOM   3486 C  CB    . THR B 1 175 ? -28.377 -6.407  -53.550 1.00 57.42  ? 184 THR B CB    1 
ATOM   3487 O  OG1   . THR B 1 175 ? -27.694 -7.128  -54.579 1.00 72.00  ? 184 THR B OG1   1 
ATOM   3488 C  CG2   . THR B 1 175 ? -27.684 -6.680  -52.235 1.00 50.42  ? 184 THR B CG2   1 
ATOM   3489 N  N     . ILE B 1 176 ? -31.152 -8.531  -52.359 1.00 51.45  ? 185 ILE B N     1 
ATOM   3490 C  CA    . ILE B 1 176 ? -31.497 -9.877  -51.817 1.00 56.76  ? 185 ILE B CA    1 
ATOM   3491 C  C     . ILE B 1 176 ? -32.380 -10.566 -52.848 1.00 58.62  ? 185 ILE B C     1 
ATOM   3492 O  O     . ILE B 1 176 ? -33.530 -10.139 -53.006 1.00 54.29  ? 185 ILE B O     1 
ATOM   3493 C  CB    . ILE B 1 176 ? -32.173 -9.745  -50.433 1.00 56.27  ? 185 ILE B CB    1 
ATOM   3494 C  CG1   . ILE B 1 176 ? -31.281 -8.948  -49.481 1.00 57.92  ? 185 ILE B CG1   1 
ATOM   3495 C  CG2   . ILE B 1 176 ? -32.546 -11.104 -49.870 1.00 50.02  ? 185 ILE B CG2   1 
ATOM   3496 C  CD1   . ILE B 1 176 ? -29.890 -9.549  -49.319 1.00 57.81  ? 185 ILE B CD1   1 
ATOM   3497 N  N     . LEU B 1 177 ? -31.827 -11.565 -53.537 1.00 63.81  ? 186 LEU B N     1 
ATOM   3498 C  CA    . LEU B 1 177 ? -32.569 -12.414 -54.500 1.00 64.17  ? 186 LEU B CA    1 
ATOM   3499 C  C     . LEU B 1 177 ? -33.797 -12.971 -53.776 1.00 73.60  ? 186 LEU B C     1 
ATOM   3500 O  O     . LEU B 1 177 ? -33.687 -13.209 -52.559 1.00 68.92  ? 186 LEU B O     1 
ATOM   3501 C  CB    . LEU B 1 177 ? -31.666 -13.550 -55.004 1.00 59.60  ? 186 LEU B CB    1 
ATOM   3502 C  CG    . LEU B 1 177 ? -30.318 -13.166 -55.635 1.00 56.82  ? 186 LEU B CG    1 
ATOM   3503 C  CD1   . LEU B 1 177 ? -29.674 -14.383 -56.256 1.00 53.79  ? 186 LEU B CD1   1 
ATOM   3504 C  CD2   . LEU B 1 177 ? -30.431 -12.058 -56.684 1.00 49.35  ? 186 LEU B CD2   1 
ATOM   3505 N  N     . ASP B 1 178 ? -34.922 -13.119 -54.482 1.00 79.08  ? 187 ASP B N     1 
ATOM   3506 C  CA    . ASP B 1 178 ? -36.064 -13.965 -54.047 1.00 83.12  ? 187 ASP B CA    1 
ATOM   3507 C  C     . ASP B 1 178 ? -35.899 -15.331 -54.730 1.00 83.65  ? 187 ASP B C     1 
ATOM   3508 O  O     . ASP B 1 178 ? -34.848 -15.532 -55.379 1.00 74.70  ? 187 ASP B O     1 
ATOM   3509 C  CB    . ASP B 1 178 ? -37.422 -13.303 -54.313 1.00 90.42  ? 187 ASP B CB    1 
ATOM   3510 C  CG    . ASP B 1 178 ? -38.494 -13.698 -53.295 1.00 99.06  ? 187 ASP B CG    1 
ATOM   3511 O  OD1   . ASP B 1 178 ? -38.483 -14.871 -52.851 1.00 94.41  ? 187 ASP B OD1   1 
ATOM   3512 O  OD2   . ASP B 1 178 ? -39.324 -12.833 -52.934 1.00 96.36  ? 187 ASP B OD2   1 
ATOM   3513 N  N     . TRP B 1 179 ? -36.902 -16.208 -54.615 1.00 83.25  ? 188 TRP B N     1 
ATOM   3514 C  CA    . TRP B 1 179 ? -36.792 -17.669 -54.873 1.00 87.16  ? 188 TRP B CA    1 
ATOM   3515 C  C     . TRP B 1 179 ? -36.553 -18.005 -56.350 1.00 83.75  ? 188 TRP B C     1 
ATOM   3516 O  O     . TRP B 1 179 ? -36.163 -19.149 -56.576 1.00 96.74  ? 188 TRP B O     1 
ATOM   3517 C  CB    . TRP B 1 179 ? -38.020 -18.414 -54.341 1.00 92.34  ? 188 TRP B CB    1 
ATOM   3518 C  CG    . TRP B 1 179 ? -37.918 -18.783 -52.892 1.00 108.88 ? 188 TRP B CG    1 
ATOM   3519 C  CD1   . TRP B 1 179 ? -38.719 -18.351 -51.873 1.00 114.87 ? 188 TRP B CD1   1 
ATOM   3520 C  CD2   . TRP B 1 179 ? -36.956 -19.676 -52.294 1.00 116.77 ? 188 TRP B CD2   1 
ATOM   3521 N  NE1   . TRP B 1 179 ? -38.325 -18.910 -50.686 1.00 122.18 ? 188 TRP B NE1   1 
ATOM   3522 C  CE2   . TRP B 1 179 ? -37.243 -19.724 -50.911 1.00 117.17 ? 188 TRP B CE2   1 
ATOM   3523 C  CE3   . TRP B 1 179 ? -35.887 -20.441 -52.786 1.00 120.69 ? 188 TRP B CE3   1 
ATOM   3524 C  CZ2   . TRP B 1 179 ? -36.495 -20.501 -50.025 1.00 112.05 ? 188 TRP B CZ2   1 
ATOM   3525 C  CZ3   . TRP B 1 179 ? -35.152 -21.212 -51.910 1.00 108.85 ? 188 TRP B CZ3   1 
ATOM   3526 C  CH2   . TRP B 1 179 ? -35.455 -21.241 -50.547 1.00 108.82 ? 188 TRP B CH2   1 
ATOM   3527 N  N     . GLU B 1 180 ? -36.783 -17.109 -57.320 1.00 83.26  ? 189 GLU B N     1 
ATOM   3528 C  CA    . GLU B 1 180 ? -36.575 -17.452 -58.762 1.00 79.27  ? 189 GLU B CA    1 
ATOM   3529 C  C     . GLU B 1 180 ? -35.513 -16.548 -59.402 1.00 74.94  ? 189 GLU B C     1 
ATOM   3530 O  O     . GLU B 1 180 ? -35.103 -16.863 -60.521 1.00 71.14  ? 189 GLU B O     1 
ATOM   3531 C  CB    . GLU B 1 180 ? -37.895 -17.436 -59.548 1.00 94.69  ? 189 GLU B CB    1 
ATOM   3532 C  CG    . GLU B 1 180 ? -38.233 -16.120 -60.245 1.00 98.53  ? 189 GLU B CG    1 
ATOM   3533 C  CD    . GLU B 1 180 ? -38.439 -14.944 -59.306 1.00 103.62 ? 189 GLU B CD    1 
ATOM   3534 O  OE1   . GLU B 1 180 ? -38.719 -15.198 -58.107 1.00 86.55  ? 189 GLU B OE1   1 
ATOM   3535 O  OE2   . GLU B 1 180 ? -38.304 -13.782 -59.772 1.00 96.25  ? 189 GLU B OE2   1 
ATOM   3536 N  N     . ASP B 1 181 ? -35.053 -15.496 -58.721 1.00 69.72  ? 190 ASP B N     1 
ATOM   3537 C  CA    . ASP B 1 181 ? -34.097 -14.504 -59.283 1.00 67.11  ? 190 ASP B CA    1 
ATOM   3538 C  C     . ASP B 1 181 ? -32.789 -15.210 -59.671 1.00 69.38  ? 190 ASP B C     1 
ATOM   3539 O  O     . ASP B 1 181 ? -32.342 -16.103 -58.925 1.00 67.38  ? 190 ASP B O     1 
ATOM   3540 C  CB    . ASP B 1 181 ? -33.895 -13.352 -58.301 1.00 68.19  ? 190 ASP B CB    1 
ATOM   3541 C  CG    . ASP B 1 181 ? -35.173 -12.559 -58.097 1.00 74.35  ? 190 ASP B CG    1 
ATOM   3542 O  OD1   . ASP B 1 181 ? -35.611 -11.919 -59.076 1.00 80.09  ? 190 ASP B OD1   1 
ATOM   3543 O  OD2   . ASP B 1 181 ? -35.754 -12.621 -56.981 1.00 71.20  ? 190 ASP B OD2   1 
ATOM   3544 N  N     . SER B 1 182 ? -32.234 -14.842 -60.830 1.00 63.13  ? 191 SER B N     1 
ATOM   3545 C  CA    . SER B 1 182 ? -30.880 -15.219 -61.303 1.00 62.37  ? 191 SER B CA    1 
ATOM   3546 C  C     . SER B 1 182 ? -29.827 -14.579 -60.397 1.00 58.49  ? 191 SER B C     1 
ATOM   3547 O  O     . SER B 1 182 ? -30.023 -13.419 -59.968 1.00 60.06  ? 191 SER B O     1 
ATOM   3548 C  CB    . SER B 1 182 ? -30.627 -14.811 -62.752 1.00 63.04  ? 191 SER B CB    1 
ATOM   3549 O  OG    . SER B 1 182 ? -31.785 -14.945 -63.563 1.00 73.47  ? 191 SER B OG    1 
ATOM   3550 N  N     . LEU B 1 183 ? -28.717 -15.291 -60.204 1.00 60.86  ? 192 LEU B N     1 
ATOM   3551 C  CA    . LEU B 1 183 ? -27.514 -14.833 -59.463 1.00 59.09  ? 192 LEU B CA    1 
ATOM   3552 C  C     . LEU B 1 183 ? -26.905 -13.632 -60.184 1.00 64.01  ? 192 LEU B C     1 
ATOM   3553 O  O     . LEU B 1 183 ? -26.885 -13.579 -61.412 1.00 66.87  ? 192 LEU B O     1 
ATOM   3554 C  CB    . LEU B 1 183 ? -26.523 -16.004 -59.333 1.00 58.17  ? 192 LEU B CB    1 
ATOM   3555 C  CG    . LEU B 1 183 ? -26.622 -16.796 -58.023 1.00 63.12  ? 192 LEU B CG    1 
ATOM   3556 C  CD1   . LEU B 1 183 ? -28.014 -17.375 -57.817 1.00 64.85  ? 192 LEU B CD1   1 
ATOM   3557 C  CD2   . LEU B 1 183 ? -25.591 -17.910 -57.953 1.00 64.92  ? 192 LEU B CD2   1 
ATOM   3558 N  N     . PRO B 1 184 ? -26.417 -12.609 -59.446 1.00 65.55  ? 193 PRO B N     1 
ATOM   3559 C  CA    . PRO B 1 184 ? -25.678 -11.512 -60.064 1.00 64.39  ? 193 PRO B CA    1 
ATOM   3560 C  C     . PRO B 1 184 ? -24.569 -12.056 -60.971 1.00 72.12  ? 193 PRO B C     1 
ATOM   3561 O  O     . PRO B 1 184 ? -23.762 -12.834 -60.490 1.00 74.46  ? 193 PRO B O     1 
ATOM   3562 C  CB    . PRO B 1 184 ? -25.067 -10.710 -58.896 1.00 63.11  ? 193 PRO B CB    1 
ATOM   3563 C  CG    . PRO B 1 184 ? -25.487 -11.458 -57.618 1.00 66.28  ? 193 PRO B CG    1 
ATOM   3564 C  CD    . PRO B 1 184 ? -26.585 -12.429 -57.996 1.00 61.70  ? 193 PRO B CD    1 
ATOM   3565 N  N     . ASP B 1 185 ? -24.528 -11.579 -62.218 1.00 78.01  ? 194 ASP B N     1 
ATOM   3566 C  CA    . ASP B 1 185 ? -23.650 -12.079 -63.311 1.00 73.66  ? 194 ASP B CA    1 
ATOM   3567 C  C     . ASP B 1 185 ? -22.177 -11.761 -63.028 1.00 65.20  ? 194 ASP B C     1 
ATOM   3568 O  O     . ASP B 1 185 ? -21.321 -12.629 -63.279 1.00 58.95  ? 194 ASP B O     1 
ATOM   3569 C  CB    . ASP B 1 185 ? -24.065 -11.491 -64.664 1.00 82.83  ? 194 ASP B CB    1 
ATOM   3570 C  CG    . ASP B 1 185 ? -25.528 -11.694 -65.036 1.00 80.73  ? 194 ASP B CG    1 
ATOM   3571 O  OD1   . ASP B 1 185 ? -26.328 -12.072 -64.155 1.00 79.79  ? 194 ASP B OD1   1 
ATOM   3572 O  OD2   . ASP B 1 185 ? -25.856 -11.450 -66.204 1.00 80.05  ? 194 ASP B OD2   1 
ATOM   3573 N  N     . ARG B 1 186 ? -21.854 -10.554 -62.572 1.00 68.11  ? 195 ARG B N     1 
ATOM   3574 C  CA    . ARG B 1 186 ? -20.431 -10.214 -62.316 1.00 71.44  ? 195 ARG B CA    1 
ATOM   3575 C  C     . ARG B 1 186 ? -19.928 -11.130 -61.192 1.00 67.64  ? 195 ARG B C     1 
ATOM   3576 O  O     . ARG B 1 186 ? -18.872 -11.786 -61.394 1.00 63.22  ? 195 ARG B O     1 
ATOM   3577 C  CB    . ARG B 1 186 ? -20.242 -8.724  -62.022 1.00 77.40  ? 195 ARG B CB    1 
ATOM   3578 C  CG    . ARG B 1 186 ? -18.803 -8.251  -62.178 1.00 83.65  ? 195 ARG B CG    1 
ATOM   3579 C  CD    . ARG B 1 186 ? -18.711 -6.854  -62.763 1.00 95.43  ? 195 ARG B CD    1 
ATOM   3580 N  NE    . ARG B 1 186 ? -17.360 -6.306  -62.729 1.00 95.93  ? 195 ARG B NE    1 
ATOM   3581 C  CZ    . ARG B 1 186 ? -16.745 -5.862  -61.635 1.00 100.52 ? 195 ARG B CZ    1 
ATOM   3582 N  NH1   . ARG B 1 186 ? -17.349 -5.913  -60.456 1.00 93.47  ? 195 ARG B NH1   1 
ATOM   3583 N  NH2   . ARG B 1 186 ? -15.517 -5.371  -61.723 1.00 103.49 ? 195 ARG B NH2   1 
ATOM   3584 N  N     . ASP B 1 187 ? -20.693 -11.231 -60.094 1.00 65.40  ? 196 ASP B N     1 
ATOM   3585 C  CA    . ASP B 1 187 ? -20.302 -11.996 -58.875 1.00 69.73  ? 196 ASP B CA    1 
ATOM   3586 C  C     . ASP B 1 187 ? -20.167 -13.475 -59.245 1.00 61.72  ? 196 ASP B C     1 
ATOM   3587 O  O     . ASP B 1 187 ? -19.143 -14.058 -58.888 1.00 60.31  ? 196 ASP B O     1 
ATOM   3588 C  CB    . ASP B 1 187 ? -21.256 -11.757 -57.697 1.00 72.44  ? 196 ASP B CB    1 
ATOM   3589 C  CG    . ASP B 1 187 ? -21.252 -10.321 -57.189 1.00 74.14  ? 196 ASP B CG    1 
ATOM   3590 O  OD1   . ASP B 1 187 ? -21.286 -9.400  -58.030 1.00 84.73  ? 196 ASP B OD1   1 
ATOM   3591 O  OD2   . ASP B 1 187 ? -21.204 -10.130 -55.960 1.00 79.83  ? 196 ASP B OD2   1 
ATOM   3592 N  N     . LEU B 1 188 ? -21.148 -14.029 -59.961 1.00 65.58  ? 197 LEU B N     1 
ATOM   3593 C  CA    . LEU B 1 188 ? -21.165 -15.442 -60.422 1.00 65.76  ? 197 LEU B CA    1 
ATOM   3594 C  C     . LEU B 1 188 ? -19.992 -15.693 -61.374 1.00 69.41  ? 197 LEU B C     1 
ATOM   3595 O  O     . LEU B 1 188 ? -19.387 -16.783 -61.307 1.00 70.89  ? 197 LEU B O     1 
ATOM   3596 C  CB    . LEU B 1 188 ? -22.479 -15.732 -61.148 1.00 70.54  ? 197 LEU B CB    1 
ATOM   3597 C  CG    . LEU B 1 188 ? -22.528 -17.074 -61.876 1.00 65.85  ? 197 LEU B CG    1 
ATOM   3598 C  CD1   . LEU B 1 188 ? -22.173 -18.208 -60.936 1.00 62.23  ? 197 LEU B CD1   1 
ATOM   3599 C  CD2   . LEU B 1 188 ? -23.901 -17.300 -62.487 1.00 71.41  ? 197 LEU B CD2   1 
ATOM   3600 N  N     . ALA B 1 189 ? -19.722 -14.741 -62.264 1.00 63.25  ? 198 ALA B N     1 
ATOM   3601 C  CA    . ALA B 1 189 ? -18.626 -14.849 -63.249 1.00 64.42  ? 198 ALA B CA    1 
ATOM   3602 C  C     . ALA B 1 189 ? -17.310 -14.988 -62.486 1.00 62.30  ? 198 ALA B C     1 
ATOM   3603 O  O     . ALA B 1 189 ? -16.629 -16.016 -62.690 1.00 59.17  ? 198 ALA B O     1 
ATOM   3604 C  CB    . ALA B 1 189 ? -18.601 -13.661 -64.172 1.00 61.56  ? 198 ALA B CB    1 
ATOM   3605 N  N     . LEU B 1 190 ? -16.991 -13.997 -61.643 1.00 60.29  ? 199 LEU B N     1 
ATOM   3606 C  CA    . LEU B 1 190 ? -15.713 -13.927 -60.880 1.00 60.75  ? 199 LEU B CA    1 
ATOM   3607 C  C     . LEU B 1 190 ? -15.554 -15.210 -60.060 1.00 61.42  ? 199 LEU B C     1 
ATOM   3608 O  O     . LEU B 1 190 ? -14.450 -15.776 -60.036 1.00 62.76  ? 199 LEU B O     1 
ATOM   3609 C  CB    . LEU B 1 190 ? -15.715 -12.680 -59.983 1.00 64.49  ? 199 LEU B CB    1 
ATOM   3610 C  CG    . LEU B 1 190 ? -15.640 -11.330 -60.706 1.00 62.49  ? 199 LEU B CG    1 
ATOM   3611 C  CD1   . LEU B 1 190 ? -15.705 -10.164 -59.729 1.00 63.15  ? 199 LEU B CD1   1 
ATOM   3612 C  CD2   . LEU B 1 190 ? -14.374 -11.225 -61.535 1.00 68.24  ? 199 LEU B CD2   1 
ATOM   3613 N  N     . ALA B 1 191 ? -16.658 -15.685 -59.482 1.00 66.78  ? 200 ALA B N     1 
ATOM   3614 C  CA    . ALA B 1 191 ? -16.709 -16.865 -58.592 1.00 65.58  ? 200 ALA B CA    1 
ATOM   3615 C  C     . ALA B 1 191 ? -16.350 -18.132 -59.382 1.00 68.15  ? 200 ALA B C     1 
ATOM   3616 O  O     . ALA B 1 191 ? -15.575 -18.992 -58.830 1.00 63.50  ? 200 ALA B O     1 
ATOM   3617 C  CB    . ALA B 1 191 ? -18.080 -16.939 -57.958 1.00 64.34  ? 200 ALA B CB    1 
ATOM   3618 N  N     . ASP B 1 192 ? -16.905 -18.259 -60.600 1.00 63.26  ? 201 ASP B N     1 
ATOM   3619 C  CA    . ASP B 1 192 ? -16.706 -19.436 -61.494 1.00 68.31  ? 201 ASP B CA    1 
ATOM   3620 C  C     . ASP B 1 192 ? -15.245 -19.468 -61.955 1.00 58.26  ? 201 ASP B C     1 
ATOM   3621 O  O     . ASP B 1 192 ? -14.648 -20.555 -61.930 1.00 58.26  ? 201 ASP B O     1 
ATOM   3622 C  CB    . ASP B 1 192 ? -17.636 -19.438 -62.713 1.00 75.86  ? 201 ASP B CB    1 
ATOM   3623 C  CG    . ASP B 1 192 ? -17.461 -20.674 -63.593 1.00 80.08  ? 201 ASP B CG    1 
ATOM   3624 O  OD1   . ASP B 1 192 ? -18.074 -21.701 -63.264 1.00 81.76  ? 201 ASP B OD1   1 
ATOM   3625 O  OD2   . ASP B 1 192 ? -16.690 -20.610 -64.587 1.00 78.00  ? 201 ASP B OD2   1 
ATOM   3626 N  N     . GLU B 1 193 ? -14.703 -18.312 -62.337 1.00 54.36  ? 202 GLU B N     1 
ATOM   3627 C  CA    . GLU B 1 193 ? -13.265 -18.136 -62.678 1.00 57.39  ? 202 GLU B CA    1 
ATOM   3628 C  C     . GLU B 1 193 ? -12.415 -18.604 -61.491 1.00 56.77  ? 202 GLU B C     1 
ATOM   3629 O  O     . GLU B 1 193 ? -11.608 -19.559 -61.645 1.00 59.96  ? 202 GLU B O     1 
ATOM   3630 C  CB    . GLU B 1 193 ? -12.963 -16.687 -63.064 1.00 60.55  ? 202 GLU B CB    1 
ATOM   3631 C  CG    . GLU B 1 193 ? -11.799 -16.578 -64.037 1.00 71.76  ? 202 GLU B CG    1 
ATOM   3632 C  CD    . GLU B 1 193 ? -10.944 -15.323 -63.955 1.00 77.20  ? 202 GLU B CD    1 
ATOM   3633 O  OE1   . GLU B 1 193 ? -10.956 -14.548 -64.931 1.00 86.93  ? 202 GLU B OE1   1 
ATOM   3634 O  OE2   . GLU B 1 193 ? -10.229 -15.150 -62.938 1.00 77.23  ? 202 GLU B OE2   1 
ATOM   3635 N  N     . ALA B 1 194 ? -12.611 -18.004 -60.321 1.00 61.39  ? 203 ALA B N     1 
ATOM   3636 C  CA    . ALA B 1 194 ? -11.795 -18.309 -59.117 1.00 61.04  ? 203 ALA B CA    1 
ATOM   3637 C  C     . ALA B 1 194 ? -11.869 -19.810 -58.798 1.00 57.55  ? 203 ALA B C     1 
ATOM   3638 O  O     . ALA B 1 194 ? -10.818 -20.400 -58.486 1.00 54.83  ? 203 ALA B O     1 
ATOM   3639 C  CB    . ALA B 1 194 ? -12.244 -17.458 -57.965 1.00 56.83  ? 203 ALA B CB    1 
ATOM   3640 N  N     . SER B 1 195 ? -13.045 -20.427 -58.937 1.00 58.35  ? 204 SER B N     1 
ATOM   3641 C  CA    . SER B 1 195 ? -13.233 -21.870 -58.628 1.00 59.48  ? 204 SER B CA    1 
ATOM   3642 C  C     . SER B 1 195 ? -12.514 -22.717 -59.677 1.00 57.65  ? 204 SER B C     1 
ATOM   3643 O  O     . SER B 1 195 ? -11.657 -23.524 -59.277 1.00 52.98  ? 204 SER B O     1 
ATOM   3644 C  CB    . SER B 1 195 ? -14.679 -22.238 -58.498 1.00 61.92  ? 204 SER B CB    1 
ATOM   3645 O  OG    . SER B 1 195 ? -15.330 -21.374 -57.582 1.00 63.71  ? 204 SER B OG    1 
ATOM   3646 N  N     . ARG B 1 196 ? -12.824 -22.532 -60.966 1.00 64.66  ? 205 ARG B N     1 
ATOM   3647 C  CA    . ARG B 1 196 ? -12.154 -23.270 -62.079 1.00 67.35  ? 205 ARG B CA    1 
ATOM   3648 C  C     . ARG B 1 196 ? -10.624 -23.224 -61.892 1.00 60.25  ? 205 ARG B C     1 
ATOM   3649 O  O     . ARG B 1 196 ? -9.994  -24.276 -61.916 1.00 53.51  ? 205 ARG B O     1 
ATOM   3650 C  CB    . ARG B 1 196 ? -12.566 -22.706 -63.447 1.00 78.41  ? 205 ARG B CB    1 
ATOM   3651 C  CG    . ARG B 1 196 ? -13.988 -23.063 -63.875 1.00 88.25  ? 205 ARG B CG    1 
ATOM   3652 C  CD    . ARG B 1 196 ? -14.374 -22.614 -65.279 1.00 84.33  ? 205 ARG B CD    1 
ATOM   3653 N  NE    . ARG B 1 196 ? -14.147 -21.191 -65.526 1.00 81.64  ? 205 ARG B NE    1 
ATOM   3654 C  CZ    . ARG B 1 196 ? -13.210 -20.670 -66.328 1.00 88.23  ? 205 ARG B CZ    1 
ATOM   3655 N  NH1   . ARG B 1 196 ? -12.372 -21.439 -67.004 1.00 88.58  ? 205 ARG B NH1   1 
ATOM   3656 N  NH2   . ARG B 1 196 ? -13.119 -19.358 -66.466 1.00 92.99  ? 205 ARG B NH2   1 
ATOM   3657 N  N     . ASN B 1 197 ? -10.025 -22.058 -61.660 1.00 67.75  ? 206 ASN B N     1 
ATOM   3658 C  CA    . ASN B 1 197 ? -8.545  -21.912 -61.759 1.00 75.35  ? 206 ASN B CA    1 
ATOM   3659 C  C     . ASN B 1 197 ? -7.866  -22.093 -60.385 1.00 72.20  ? 206 ASN B C     1 
ATOM   3660 O  O     . ASN B 1 197 ? -6.771  -21.535 -60.218 1.00 73.98  ? 206 ASN B O     1 
ATOM   3661 C  CB    . ASN B 1 197 ? -8.208  -20.596 -62.477 1.00 83.75  ? 206 ASN B CB    1 
ATOM   3662 C  CG    . ASN B 1 197 ? -8.712  -20.566 -63.914 1.00 80.76  ? 206 ASN B CG    1 
ATOM   3663 O  OD1   . ASN B 1 197 ? -8.157  -21.221 -64.797 1.00 84.45  ? 206 ASN B OD1   1 
ATOM   3664 N  ND2   . ASN B 1 197 ? -9.775  -19.822 -64.173 1.00 78.19  ? 206 ASN B ND2   1 
ATOM   3665 N  N     . ALA B 1 198 ? -8.444  -22.888 -59.468 1.00 64.37  ? 207 ALA B N     1 
ATOM   3666 C  CA    . ALA B 1 198 ? -7.926  -23.147 -58.102 1.00 57.60  ? 207 ALA B CA    1 
ATOM   3667 C  C     . ALA B 1 198 ? -7.392  -24.570 -57.991 1.00 62.13  ? 207 ALA B C     1 
ATOM   3668 O  O     . ALA B 1 198 ? -7.947  -25.467 -58.631 1.00 70.72  ? 207 ALA B O     1 
ATOM   3669 C  CB    . ALA B 1 198 ? -9.009  -22.955 -57.083 1.00 61.80  ? 207 ALA B CB    1 
ATOM   3670 N  N     . ASP B 1 199 ? -6.364  -24.760 -57.170 1.00 61.75  ? 208 ASP B N     1 
ATOM   3671 C  CA    . ASP B 1 199 ? -5.818  -26.091 -56.816 1.00 56.25  ? 208 ASP B CA    1 
ATOM   3672 C  C     . ASP B 1 199 ? -6.251  -26.434 -55.390 1.00 52.79  ? 208 ASP B C     1 
ATOM   3673 O  O     . ASP B 1 199 ? -5.882  -27.532 -54.906 1.00 54.02  ? 208 ASP B O     1 
ATOM   3674 C  CB    . ASP B 1 199 ? -4.298  -26.101 -56.993 1.00 70.33  ? 208 ASP B CB    1 
ATOM   3675 C  CG    . ASP B 1 199 ? -3.580  -25.131 -56.077 1.00 72.61  ? 208 ASP B CG    1 
ATOM   3676 O  OD1   . ASP B 1 199 ? -4.156  -24.809 -55.030 1.00 85.29  ? 208 ASP B OD1   1 
ATOM   3677 O  OD2   . ASP B 1 199 ? -2.462  -24.703 -56.423 1.00 81.88  ? 208 ASP B OD2   1 
ATOM   3678 N  N     . LEU B 1 200 ? -6.980  -25.525 -54.728 1.00 50.45  ? 209 LEU B N     1 
ATOM   3679 C  CA    . LEU B 1 200 ? -7.618  -25.807 -53.419 1.00 46.43  ? 209 LEU B CA    1 
ATOM   3680 C  C     . LEU B 1 200 ? -8.843  -24.925 -53.189 1.00 46.29  ? 209 LEU B C     1 
ATOM   3681 O  O     . LEU B 1 200 ? -8.678  -23.698 -53.093 1.00 54.36  ? 209 LEU B O     1 
ATOM   3682 C  CB    . LEU B 1 200 ? -6.596  -25.605 -52.304 1.00 47.56  ? 209 LEU B CB    1 
ATOM   3683 C  CG    . LEU B 1 200 ? -7.096  -25.948 -50.905 1.00 46.06  ? 209 LEU B CG    1 
ATOM   3684 C  CD1   . LEU B 1 200 ? -7.514  -27.399 -50.845 1.00 50.31  ? 209 LEU B CD1   1 
ATOM   3685 C  CD2   . LEU B 1 200 ? -6.031  -25.675 -49.855 1.00 46.51  ? 209 LEU B CD2   1 
ATOM   3686 N  N     . SER B 1 201 ? -10.008 -25.561 -53.048 1.00 47.74  ? 210 SER B N     1 
ATOM   3687 C  CA    . SER B 1 201 ? -11.264 -24.980 -52.498 1.00 46.56  ? 210 SER B CA    1 
ATOM   3688 C  C     . SER B 1 201 ? -11.553 -25.526 -51.092 1.00 44.05  ? 210 SER B C     1 
ATOM   3689 O  O     . SER B 1 201 ? -11.359 -26.726 -50.866 1.00 46.02  ? 210 SER B O     1 
ATOM   3690 C  CB    . SER B 1 201 ? -12.381 -25.256 -53.414 1.00 43.31  ? 210 SER B CB    1 
ATOM   3691 O  OG    . SER B 1 201 ? -12.222 -24.452 -54.562 1.00 47.53  ? 210 SER B OG    1 
ATOM   3692 N  N     . ILE B 1 202 ? -11.917 -24.660 -50.147 1.00 46.76  ? 211 ILE B N     1 
ATOM   3693 C  CA    . ILE B 1 202 ? -12.313 -25.058 -48.756 1.00 40.98  ? 211 ILE B CA    1 
ATOM   3694 C  C     . ILE B 1 202 ? -13.693 -24.462 -48.523 1.00 36.38  ? 211 ILE B C     1 
ATOM   3695 O  O     . ILE B 1 202 ? -13.867 -23.290 -48.859 1.00 39.07  ? 211 ILE B O     1 
ATOM   3696 C  CB    . ILE B 1 202 ? -11.284 -24.579 -47.724 1.00 43.28  ? 211 ILE B CB    1 
ATOM   3697 C  CG1   . ILE B 1 202 ? -9.871  -24.996 -48.126 1.00 44.94  ? 211 ILE B CG1   1 
ATOM   3698 C  CG2   . ILE B 1 202 ? -11.640 -25.057 -46.325 1.00 43.19  ? 211 ILE B CG2   1 
ATOM   3699 C  CD1   . ILE B 1 202 ? -8.787  -24.077 -47.559 1.00 54.10  ? 211 ILE B CD1   1 
ATOM   3700 N  N     . THR B 1 203 ? -14.660 -25.275 -48.112 1.00 38.04  ? 212 THR B N     1 
ATOM   3701 C  CA    . THR B 1 203 ? -16.057 -24.857 -47.831 1.00 39.42  ? 212 THR B CA    1 
ATOM   3702 C  C     . THR B 1 203 ? -16.209 -24.800 -46.314 1.00 43.62  ? 212 THR B C     1 
ATOM   3703 O  O     . THR B 1 203 ? -15.753 -25.725 -45.652 1.00 43.46  ? 212 THR B O     1 
ATOM   3704 C  CB    . THR B 1 203 ? -17.057 -25.812 -48.487 1.00 44.30  ? 212 THR B CB    1 
ATOM   3705 O  OG1   . THR B 1 203 ? -16.929 -27.106 -47.892 1.00 44.48  ? 212 THR B OG1   1 
ATOM   3706 C  CG2   . THR B 1 203 ? -16.828 -25.944 -49.974 1.00 44.07  ? 212 THR B CG2   1 
ATOM   3707 N  N     . LEU B 1 204 ? -16.678 -23.675 -45.796 1.00 48.17  ? 213 LEU B N     1 
ATOM   3708 C  CA    . LEU B 1 204 ? -16.879 -23.461 -44.347 1.00 48.15  ? 213 LEU B CA    1 
ATOM   3709 C  C     . LEU B 1 204 ? -18.365 -23.159 -44.141 1.00 51.12  ? 213 LEU B C     1 
ATOM   3710 O  O     . LEU B 1 204 ? -18.912 -22.318 -44.881 1.00 48.97  ? 213 LEU B O     1 
ATOM   3711 C  CB    . LEU B 1 204 ? -16.034 -22.294 -43.839 1.00 45.64  ? 213 LEU B CB    1 
ATOM   3712 C  CG    . LEU B 1 204 ? -14.550 -22.289 -44.181 1.00 48.11  ? 213 LEU B CG    1 
ATOM   3713 C  CD1   . LEU B 1 204 ? -13.984 -20.925 -43.809 1.00 47.77  ? 213 LEU B CD1   1 
ATOM   3714 C  CD2   . LEU B 1 204 ? -13.782 -23.401 -43.469 1.00 47.34  ? 213 LEU B CD2   1 
ATOM   3715 N  N     . GLY B 1 205 ? -18.982 -23.874 -43.202 1.00 48.08  ? 214 GLY B N     1 
ATOM   3716 C  CA    . GLY B 1 205 ? -20.392 -23.739 -42.824 1.00 49.41  ? 214 GLY B CA    1 
ATOM   3717 C  C     . GLY B 1 205 ? -21.348 -23.609 -43.997 1.00 49.09  ? 214 GLY B C     1 
ATOM   3718 O  O     . GLY B 1 205 ? -22.248 -22.760 -43.880 1.00 50.32  ? 214 GLY B O     1 
ATOM   3719 N  N     . THR B 1 206 ? -21.216 -24.437 -45.043 1.00 50.86  ? 215 THR B N     1 
ATOM   3720 C  CA    . THR B 1 206 ? -22.262 -24.614 -46.094 1.00 52.36  ? 215 THR B CA    1 
ATOM   3721 C  C     . THR B 1 206 ? -22.550 -26.109 -46.316 1.00 46.95  ? 215 THR B C     1 
ATOM   3722 O  O     . THR B 1 206 ? -21.597 -26.887 -46.449 1.00 46.72  ? 215 THR B O     1 
ATOM   3723 C  CB    . THR B 1 206 ? -21.929 -23.854 -47.395 1.00 52.14  ? 215 THR B CB    1 
ATOM   3724 O  OG1   . THR B 1 206 ? -22.936 -24.163 -48.367 1.00 46.43  ? 215 THR B OG1   1 
ATOM   3725 C  CG2   . THR B 1 206 ? -20.560 -24.170 -47.954 1.00 49.60  ? 215 THR B CG2   1 
ATOM   3726 N  N     . SER B 1 207 ? -23.840 -26.434 -46.410 1.00 43.49  ? 216 SER B N     1 
ATOM   3727 C  CA    . SER B 1 207 ? -24.449 -27.736 -46.807 1.00 49.62  ? 216 SER B CA    1 
ATOM   3728 C  C     . SER B 1 207 ? -24.355 -28.004 -48.326 1.00 47.63  ? 216 SER B C     1 
ATOM   3729 O  O     . SER B 1 207 ? -24.675 -29.118 -48.739 1.00 48.80  ? 216 SER B O     1 
ATOM   3730 C  CB    . SER B 1 207 ? -25.895 -27.724 -46.405 1.00 50.06  ? 216 SER B CB    1 
ATOM   3731 O  OG    . SER B 1 207 ? -26.548 -26.640 -47.073 1.00 50.57  ? 216 SER B OG    1 
ATOM   3732 N  N     . LEU B 1 208 ? -24.000 -27.000 -49.124 1.00 46.70  ? 217 LEU B N     1 
ATOM   3733 C  CA    . LEU B 1 208 ? -23.781 -27.077 -50.598 1.00 51.03  ? 217 LEU B CA    1 
ATOM   3734 C  C     . LEU B 1 208 ? -25.015 -27.598 -51.364 1.00 51.89  ? 217 LEU B C     1 
ATOM   3735 O  O     . LEU B 1 208 ? -24.813 -28.236 -52.414 1.00 60.66  ? 217 LEU B O     1 
ATOM   3736 C  CB    . LEU B 1 208 ? -22.569 -27.975 -50.848 1.00 50.70  ? 217 LEU B CB    1 
ATOM   3737 C  CG    . LEU B 1 208 ? -21.276 -27.511 -50.193 1.00 52.66  ? 217 LEU B CG    1 
ATOM   3738 C  CD1   . LEU B 1 208 ? -20.173 -28.511 -50.445 1.00 56.75  ? 217 LEU B CD1   1 
ATOM   3739 C  CD2   . LEU B 1 208 ? -20.865 -26.133 -50.693 1.00 53.06  ? 217 LEU B CD2   1 
ATOM   3740 N  N     . GLN B 1 209 ? -26.233 -27.274 -50.931 1.00 50.87  ? 218 GLN B N     1 
ATOM   3741 C  CA    . GLN B 1 209 ? -27.484 -27.778 -51.561 1.00 53.82  ? 218 GLN B CA    1 
ATOM   3742 C  C     . GLN B 1 209 ? -28.008 -26.848 -52.673 1.00 61.92  ? 218 GLN B C     1 
ATOM   3743 O  O     . GLN B 1 209 ? -28.804 -27.353 -53.462 1.00 66.09  ? 218 GLN B O     1 
ATOM   3744 C  CB    . GLN B 1 209 ? -28.540 -28.000 -50.477 1.00 60.29  ? 218 GLN B CB    1 
ATOM   3745 C  CG    . GLN B 1 209 ? -28.007 -28.827 -49.321 1.00 60.24  ? 218 GLN B CG    1 
ATOM   3746 C  CD    . GLN B 1 209 ? -28.869 -30.004 -48.967 1.00 69.01  ? 218 GLN B CD    1 
ATOM   3747 O  OE1   . GLN B 1 209 ? -28.648 -31.126 -49.425 1.00 91.90  ? 218 GLN B OE1   1 
ATOM   3748 N  NE2   . GLN B 1 209 ? -29.842 -29.755 -48.117 1.00 79.51  ? 218 GLN B NE2   1 
ATOM   3749 N  N     . ILE B 1 210 ? -27.605 -25.568 -52.751 1.00 61.70  ? 219 ILE B N     1 
ATOM   3750 C  CA    . ILE B 1 210 ? -28.181 -24.589 -53.723 1.00 64.87  ? 219 ILE B CA    1 
ATOM   3751 C  C     . ILE B 1 210 ? -27.472 -24.738 -55.066 1.00 64.35  ? 219 ILE B C     1 
ATOM   3752 O  O     . ILE B 1 210 ? -26.256 -24.870 -55.056 1.00 63.65  ? 219 ILE B O     1 
ATOM   3753 C  CB    . ILE B 1 210 ? -28.120 -23.158 -53.169 1.00 62.15  ? 219 ILE B CB    1 
ATOM   3754 C  CG1   . ILE B 1 210 ? -28.946 -23.064 -51.892 1.00 70.20  ? 219 ILE B CG1   1 
ATOM   3755 C  CG2   . ILE B 1 210 ? -28.578 -22.145 -54.200 1.00 62.10  ? 219 ILE B CG2   1 
ATOM   3756 C  CD1   . ILE B 1 210 ? -30.390 -23.439 -52.088 1.00 68.63  ? 219 ILE B CD1   1 
ATOM   3757 N  N     . ARG B 1 211 ? -28.225 -24.688 -56.169 1.00 75.60  ? 220 ARG B N     1 
ATOM   3758 C  CA    . ARG B 1 211 ? -27.816 -25.310 -57.455 1.00 76.88  ? 220 ARG B CA    1 
ATOM   3759 C  C     . ARG B 1 211 ? -26.552 -24.642 -57.956 1.00 84.37  ? 220 ARG B C     1 
ATOM   3760 O  O     . ARG B 1 211 ? -25.546 -25.316 -58.106 1.00 125.07 ? 220 ARG B O     1 
ATOM   3761 C  CB    . ARG B 1 211 ? -28.898 -25.285 -58.540 1.00 96.17  ? 220 ARG B CB    1 
ATOM   3762 C  CG    . ARG B 1 211 ? -28.486 -25.962 -59.844 1.00 97.22  ? 220 ARG B CG    1 
ATOM   3763 C  CD    . ARG B 1 211 ? -28.276 -27.452 -59.640 1.00 100.90 ? 220 ARG B CD    1 
ATOM   3764 N  NE    . ARG B 1 211 ? -27.856 -28.176 -60.829 1.00 100.45 ? 220 ARG B NE    1 
ATOM   3765 C  CZ    . ARG B 1 211 ? -27.262 -29.373 -60.823 1.00 104.07 ? 220 ARG B CZ    1 
ATOM   3766 N  NH1   . ARG B 1 211 ? -26.990 -29.997 -59.687 1.00 99.87  ? 220 ARG B NH1   1 
ATOM   3767 N  NH2   . ARG B 1 211 ? -26.936 -29.944 -61.969 1.00 105.21 ? 220 ARG B NH2   1 
ATOM   3768 N  N     . PRO B 1 212 ? -26.533 -23.334 -58.270 1.00 67.33  ? 221 PRO B N     1 
ATOM   3769 C  CA    . PRO B 1 212 ? -25.305 -22.758 -58.833 1.00 63.11  ? 221 PRO B CA    1 
ATOM   3770 C  C     . PRO B 1 212 ? -24.212 -22.727 -57.744 1.00 63.46  ? 221 PRO B C     1 
ATOM   3771 O  O     . PRO B 1 212 ? -23.189 -23.367 -57.886 1.00 55.90  ? 221 PRO B O     1 
ATOM   3772 C  CB    . PRO B 1 212 ? -25.723 -21.365 -59.312 1.00 64.68  ? 221 PRO B CB    1 
ATOM   3773 C  CG    . PRO B 1 212 ? -27.075 -21.090 -58.651 1.00 67.13  ? 221 PRO B CG    1 
ATOM   3774 C  CD    . PRO B 1 212 ? -27.620 -22.380 -58.053 1.00 60.22  ? 221 PRO B CD    1 
ATOM   3775 N  N     . SER B 1 213 ? -24.515 -22.076 -56.620 1.00 53.48  ? 222 SER B N     1 
ATOM   3776 C  CA    . SER B 1 213 ? -23.586 -21.764 -55.497 1.00 57.89  ? 222 SER B CA    1 
ATOM   3777 C  C     . SER B 1 213 ? -22.842 -22.993 -54.949 1.00 52.58  ? 222 SER B C     1 
ATOM   3778 O  O     . SER B 1 213 ? -21.598 -22.932 -54.823 1.00 57.62  ? 222 SER B O     1 
ATOM   3779 C  CB    . SER B 1 213 ? -24.350 -21.102 -54.409 1.00 59.18  ? 222 SER B CB    1 
ATOM   3780 O  OG    . SER B 1 213 ? -25.395 -20.311 -54.948 1.00 66.26  ? 222 SER B OG    1 
ATOM   3781 N  N     . GLY B 1 214 ? -23.563 -24.068 -54.619 1.00 52.47  ? 223 GLY B N     1 
ATOM   3782 C  CA    . GLY B 1 214 ? -22.993 -25.295 -54.018 1.00 51.04  ? 223 GLY B CA    1 
ATOM   3783 C  C     . GLY B 1 214 ? -22.142 -26.154 -54.940 1.00 58.78  ? 223 GLY B C     1 
ATOM   3784 O  O     . GLY B 1 214 ? -21.437 -27.018 -54.379 1.00 71.54  ? 223 GLY B O     1 
ATOM   3785 N  N     . ASN B 1 215 ? -22.205 -25.965 -56.274 1.00 60.72  ? 224 ASN B N     1 
ATOM   3786 C  CA    . ASN B 1 215 ? -21.455 -26.747 -57.300 1.00 64.57  ? 224 ASN B CA    1 
ATOM   3787 C  C     . ASN B 1 215 ? -20.027 -26.214 -57.487 1.00 53.94  ? 224 ASN B C     1 
ATOM   3788 O  O     . ASN B 1 215 ? -19.167 -26.979 -57.932 1.00 63.59  ? 224 ASN B O     1 
ATOM   3789 C  CB    . ASN B 1 215 ? -22.104 -26.682 -58.693 1.00 69.76  ? 224 ASN B CB    1 
ATOM   3790 C  CG    . ASN B 1 215 ? -23.372 -27.495 -58.852 1.00 75.34  ? 224 ASN B CG    1 
ATOM   3791 O  OD1   . ASN B 1 215 ? -23.830 -28.156 -57.921 1.00 68.08  ? 224 ASN B OD1   1 
ATOM   3792 N  ND2   . ASN B 1 215 ? -23.960 -27.435 -60.039 1.00 82.10  ? 224 ASN B ND2   1 
ATOM   3793 N  N     . LEU B 1 216 ? -19.805 -24.929 -57.255 1.00 56.03  ? 225 LEU B N     1 
ATOM   3794 C  CA    . LEU B 1 216 ? -18.564 -24.209 -57.656 1.00 55.64  ? 225 LEU B CA    1 
ATOM   3795 C  C     . LEU B 1 216 ? -17.335 -24.877 -57.035 1.00 56.13  ? 225 LEU B C     1 
ATOM   3796 O  O     . LEU B 1 216 ? -16.326 -25.047 -57.702 1.00 52.00  ? 225 LEU B O     1 
ATOM   3797 C  CB    . LEU B 1 216 ? -18.684 -22.741 -57.230 1.00 60.72  ? 225 LEU B CB    1 
ATOM   3798 C  CG    . LEU B 1 216 ? -19.725 -21.891 -57.962 1.00 58.02  ? 225 LEU B CG    1 
ATOM   3799 C  CD1   . LEU B 1 216 ? -19.939 -20.584 -57.219 1.00 59.10  ? 225 LEU B CD1   1 
ATOM   3800 C  CD2   . LEU B 1 216 ? -19.302 -21.601 -59.389 1.00 59.47  ? 225 LEU B CD2   1 
ATOM   3801 N  N     . PRO B 1 217 ? -17.358 -25.288 -55.745 1.00 51.63  ? 226 PRO B N     1 
ATOM   3802 C  CA    . PRO B 1 217 ? -16.277 -26.095 -55.188 1.00 54.67  ? 226 PRO B CA    1 
ATOM   3803 C  C     . PRO B 1 217 ? -15.876 -27.325 -56.011 1.00 57.29  ? 226 PRO B C     1 
ATOM   3804 O  O     . PRO B 1 217 ? -14.710 -27.662 -55.993 1.00 62.51  ? 226 PRO B O     1 
ATOM   3805 C  CB    . PRO B 1 217 ? -16.843 -26.558 -53.833 1.00 56.13  ? 226 PRO B CB    1 
ATOM   3806 C  CG    . PRO B 1 217 ? -17.779 -25.432 -53.434 1.00 55.28  ? 226 PRO B CG    1 
ATOM   3807 C  CD    . PRO B 1 217 ? -18.383 -24.961 -54.742 1.00 53.23  ? 226 PRO B CD    1 
ATOM   3808 N  N     . LEU B 1 218 ? -16.835 -27.998 -56.649 1.00 62.16  ? 227 LEU B N     1 
ATOM   3809 C  CA    . LEU B 1 218 ? -16.567 -29.196 -57.488 1.00 62.75  ? 227 LEU B CA    1 
ATOM   3810 C  C     . LEU B 1 218 ? -15.673 -28.802 -58.666 1.00 67.86  ? 227 LEU B C     1 
ATOM   3811 O  O     . LEU B 1 218 ? -14.818 -29.607 -59.001 1.00 63.12  ? 227 LEU B O     1 
ATOM   3812 C  CB    . LEU B 1 218 ? -17.874 -29.802 -58.001 1.00 66.03  ? 227 LEU B CB    1 
ATOM   3813 C  CG    . LEU B 1 218 ? -18.720 -30.555 -56.983 1.00 62.12  ? 227 LEU B CG    1 
ATOM   3814 C  CD1   . LEU B 1 218 ? -19.710 -31.467 -57.701 1.00 59.32  ? 227 LEU B CD1   1 
ATOM   3815 C  CD2   . LEU B 1 218 ? -17.848 -31.351 -56.038 1.00 65.90  ? 227 LEU B CD2   1 
ATOM   3816 N  N     . ALA B 1 219 ? -15.849 -27.598 -59.234 1.00 71.42  ? 228 ALA B N     1 
ATOM   3817 C  CA    . ALA B 1 219 ? -15.110 -27.129 -60.435 1.00 63.15  ? 228 ALA B CA    1 
ATOM   3818 C  C     . ALA B 1 219 ? -13.614 -27.025 -60.126 1.00 63.49  ? 228 ALA B C     1 
ATOM   3819 O  O     . ALA B 1 219 ? -12.822 -26.997 -61.094 1.00 56.06  ? 228 ALA B O     1 
ATOM   3820 C  CB    . ALA B 1 219 ? -15.661 -25.817 -60.938 1.00 57.66  ? 228 ALA B CB    1 
ATOM   3821 N  N     . THR B 1 220 ? -13.240 -26.941 -58.842 1.00 61.43  ? 229 THR B N     1 
ATOM   3822 C  CA    . THR B 1 220 ? -11.820 -26.961 -58.390 1.00 59.63  ? 229 THR B CA    1 
ATOM   3823 C  C     . THR B 1 220 ? -11.268 -28.367 -58.635 1.00 61.10  ? 229 THR B C     1 
ATOM   3824 O  O     . THR B 1 220 ? -10.075 -28.498 -59.006 1.00 64.45  ? 229 THR B O     1 
ATOM   3825 C  CB    . THR B 1 220 ? -11.688 -26.502 -56.928 1.00 63.51  ? 229 THR B CB    1 
ATOM   3826 O  OG1   . THR B 1 220 ? -12.150 -25.147 -56.862 1.00 66.60  ? 229 THR B OG1   1 
ATOM   3827 C  CG2   . THR B 1 220 ? -10.274 -26.578 -56.388 1.00 59.05  ? 229 THR B CG2   1 
ATOM   3828 N  N     . LYS B 1 221 ? -12.101 -29.392 -58.463 1.00 57.24  ? 230 LYS B N     1 
ATOM   3829 C  CA    . LYS B 1 221 ? -11.621 -30.794 -58.575 1.00 67.58  ? 230 LYS B CA    1 
ATOM   3830 C  C     . LYS B 1 221 ? -11.238 -31.110 -60.030 1.00 78.34  ? 230 LYS B C     1 
ATOM   3831 O  O     . LYS B 1 221 ? -10.288 -31.891 -60.212 1.00 92.36  ? 230 LYS B O     1 
ATOM   3832 C  CB    . LYS B 1 221 ? -12.626 -31.756 -57.942 1.00 68.38  ? 230 LYS B CB    1 
ATOM   3833 C  CG    . LYS B 1 221 ? -12.420 -31.917 -56.441 1.00 63.07  ? 230 LYS B CG    1 
ATOM   3834 C  CD    . LYS B 1 221 ? -12.977 -33.184 -55.857 1.00 70.11  ? 230 LYS B CD    1 
ATOM   3835 C  CE    . LYS B 1 221 ? -12.392 -34.473 -56.401 1.00 66.77  ? 230 LYS B CE    1 
ATOM   3836 N  NZ    . LYS B 1 221 ? -11.398 -35.076 -55.481 1.00 61.09  ? 230 LYS B NZ    1 
ATOM   3837 N  N     . ARG B 1 222 ? -11.882 -30.493 -61.027 1.00 82.21  ? 231 ARG B N     1 
ATOM   3838 C  CA    . ARG B 1 222 ? -11.448 -30.616 -62.447 1.00 81.89  ? 231 ARG B CA    1 
ATOM   3839 C  C     . ARG B 1 222 ? -10.005 -30.096 -62.573 1.00 82.15  ? 231 ARG B C     1 
ATOM   3840 O  O     . ARG B 1 222 ? -9.669  -29.055 -61.980 1.00 77.04  ? 231 ARG B O     1 
ATOM   3841 C  CB    . ARG B 1 222 ? -12.422 -29.923 -63.405 1.00 79.12  ? 231 ARG B CB    1 
ATOM   3842 C  CG    . ARG B 1 222 ? -12.156 -28.445 -63.654 1.00 85.68  ? 231 ARG B CG    1 
ATOM   3843 C  CD    . ARG B 1 222 ? -13.095 -27.851 -64.698 1.00 93.82  ? 231 ARG B CD    1 
ATOM   3844 N  NE    . ARG B 1 222 ? -14.521 -27.869 -64.358 1.00 90.03  ? 231 ARG B NE    1 
ATOM   3845 C  CZ    . ARG B 1 222 ? -15.528 -27.751 -65.236 1.00 91.46  ? 231 ARG B CZ    1 
ATOM   3846 N  NH1   . ARG B 1 222 ? -15.299 -27.623 -66.537 1.00 98.08  ? 231 ARG B NH1   1 
ATOM   3847 N  NH2   . ARG B 1 222 ? -16.776 -27.768 -64.807 1.00 80.90  ? 231 ARG B NH2   1 
ATOM   3848 N  N     . ARG B 1 223 ? -9.177  -30.831 -63.313 1.00 85.16  ? 232 ARG B N     1 
ATOM   3849 C  CA    . ARG B 1 223 ? -7.728  -30.553 -63.510 1.00 88.06  ? 232 ARG B CA    1 
ATOM   3850 C  C     . ARG B 1 223 ? -7.011  -30.549 -62.147 1.00 78.60  ? 232 ARG B C     1 
ATOM   3851 O  O     . ARG B 1 223 ? -6.225  -29.626 -61.868 1.00 86.16  ? 232 ARG B O     1 
ATOM   3852 C  CB    . ARG B 1 223 ? -7.545  -29.283 -64.349 1.00 93.47  ? 232 ARG B CB    1 
ATOM   3853 C  CG    . ARG B 1 223 ? -7.901  -29.482 -65.816 1.00 94.38  ? 232 ARG B CG    1 
ATOM   3854 C  CD    . ARG B 1 223 ? -7.495  -28.334 -66.714 1.00 97.94  ? 232 ARG B CD    1 
ATOM   3855 N  NE    . ARG B 1 223 ? -7.860  -27.031 -66.165 1.00 104.52 ? 232 ARG B NE    1 
ATOM   3856 C  CZ    . ARG B 1 223 ? -7.008  -26.068 -65.793 1.00 112.03 ? 232 ARG B CZ    1 
ATOM   3857 N  NH1   . ARG B 1 223 ? -7.486  -24.927 -65.321 1.00 109.30 ? 232 ARG B NH1   1 
ATOM   3858 N  NH2   . ARG B 1 223 ? -5.696  -26.225 -65.899 1.00 111.40 ? 232 ARG B NH2   1 
ATOM   3859 N  N     . GLY B 1 224 ? -7.274  -31.576 -61.339 1.00 72.68  ? 233 GLY B N     1 
ATOM   3860 C  CA    . GLY B 1 224 ? -6.317  -32.117 -60.350 1.00 72.40  ? 233 GLY B CA    1 
ATOM   3861 C  C     . GLY B 1 224 ? -6.430  -31.469 -58.983 1.00 62.65  ? 233 GLY B C     1 
ATOM   3862 O  O     . GLY B 1 224 ? -5.657  -31.879 -58.074 1.00 64.25  ? 233 GLY B O     1 
ATOM   3863 N  N     . GLY B 1 225 ? -7.336  -30.498 -58.845 1.00 49.62  ? 234 GLY B N     1 
ATOM   3864 C  CA    . GLY B 1 225 ? -7.432  -29.635 -57.656 1.00 56.49  ? 234 GLY B CA    1 
ATOM   3865 C  C     . GLY B 1 225 ? -8.143  -30.318 -56.503 1.00 51.31  ? 234 GLY B C     1 
ATOM   3866 O  O     . GLY B 1 225 ? -9.109  -31.046 -56.756 1.00 58.72  ? 234 GLY B O     1 
ATOM   3867 N  N     . ARG B 1 226 ? -7.739  -30.000 -55.278 1.00 55.23  ? 235 ARG B N     1 
ATOM   3868 C  CA    . ARG B 1 226 ? -8.243  -30.618 -54.020 1.00 59.15  ? 235 ARG B CA    1 
ATOM   3869 C  C     . ARG B 1 226 ? -9.483  -29.844 -53.523 1.00 59.78  ? 235 ARG B C     1 
ATOM   3870 O  O     . ARG B 1 226 ? -9.556  -28.605 -53.731 1.00 54.21  ? 235 ARG B O     1 
ATOM   3871 C  CB    . ARG B 1 226 ? -7.114  -30.634 -52.982 1.00 64.24  ? 235 ARG B CB    1 
ATOM   3872 C  CG    . ARG B 1 226 ? -5.777  -31.174 -53.484 1.00 68.02  ? 235 ARG B CG    1 
ATOM   3873 C  CD    . ARG B 1 226 ? -5.740  -32.670 -53.788 1.00 79.52  ? 235 ARG B CD    1 
ATOM   3874 N  NE    . ARG B 1 226 ? -4.446  -33.110 -54.332 1.00 85.27  ? 235 ARG B NE    1 
ATOM   3875 C  CZ    . ARG B 1 226 ? -3.376  -33.491 -53.613 1.00 85.72  ? 235 ARG B CZ    1 
ATOM   3876 N  NH1   . ARG B 1 226 ? -3.402  -33.506 -52.288 1.00 75.08  ? 235 ARG B NH1   1 
ATOM   3877 N  NH2   . ARG B 1 226 ? -2.270  -33.861 -54.233 1.00 84.44  ? 235 ARG B NH2   1 
ATOM   3878 N  N     . LEU B 1 227 ? -10.443 -30.545 -52.910 1.00 54.76  ? 236 LEU B N     1 
ATOM   3879 C  CA    . LEU B 1 227 ? -11.609 -29.923 -52.225 1.00 53.57  ? 236 LEU B CA    1 
ATOM   3880 C  C     . LEU B 1 227 ? -11.514 -30.269 -50.743 1.00 52.12  ? 236 LEU B C     1 
ATOM   3881 O  O     . LEU B 1 227 ? -11.221 -31.448 -50.457 1.00 50.91  ? 236 LEU B O     1 
ATOM   3882 C  CB    . LEU B 1 227 ? -12.909 -30.474 -52.810 1.00 56.25  ? 236 LEU B CB    1 
ATOM   3883 C  CG    . LEU B 1 227 ? -14.205 -30.096 -52.090 1.00 60.54  ? 236 LEU B CG    1 
ATOM   3884 C  CD1   . LEU B 1 227 ? -14.366 -28.585 -51.991 1.00 65.22  ? 236 LEU B CD1   1 
ATOM   3885 C  CD2   . LEU B 1 227 ? -15.414 -30.707 -52.793 1.00 57.12  ? 236 LEU B CD2   1 
ATOM   3886 N  N     . VAL B 1 228 ? -11.760 -29.299 -49.854 1.00 47.10  ? 237 VAL B N     1 
ATOM   3887 C  CA    . VAL B 1 228 ? -11.889 -29.553 -48.389 1.00 52.04  ? 237 VAL B CA    1 
ATOM   3888 C  C     . VAL B 1 228 ? -13.229 -28.990 -47.926 1.00 54.46  ? 237 VAL B C     1 
ATOM   3889 O  O     . VAL B 1 228 ? -13.644 -27.939 -48.444 1.00 63.12  ? 237 VAL B O     1 
ATOM   3890 C  CB    . VAL B 1 228 ? -10.729 -28.943 -47.586 1.00 51.09  ? 237 VAL B CB    1 
ATOM   3891 C  CG1   . VAL B 1 228 ? -10.901 -29.151 -46.087 1.00 53.76  ? 237 VAL B CG1   1 
ATOM   3892 C  CG2   . VAL B 1 228 ? -9.386  -29.464 -48.054 1.00 46.98  ? 237 VAL B CG2   1 
ATOM   3893 N  N     . ILE B 1 229 ? -13.876 -29.704 -47.012 1.00 52.13  ? 238 ILE B N     1 
ATOM   3894 C  CA    . ILE B 1 229 ? -15.244 -29.404 -46.518 1.00 52.52  ? 238 ILE B CA    1 
ATOM   3895 C  C     . ILE B 1 229 ? -15.225 -29.416 -44.991 1.00 55.09  ? 238 ILE B C     1 
ATOM   3896 O  O     . ILE B 1 229 ? -14.681 -30.372 -44.386 1.00 55.73  ? 238 ILE B O     1 
ATOM   3897 C  CB    . ILE B 1 229 ? -16.251 -30.388 -47.135 1.00 55.88  ? 238 ILE B CB    1 
ATOM   3898 C  CG1   . ILE B 1 229 ? -16.260 -30.211 -48.658 1.00 53.66  ? 238 ILE B CG1   1 
ATOM   3899 C  CG2   . ILE B 1 229 ? -17.641 -30.262 -46.501 1.00 50.64  ? 238 ILE B CG2   1 
ATOM   3900 C  CD1   . ILE B 1 229 ? -17.485 -30.747 -49.349 1.00 60.54  ? 238 ILE B CD1   1 
ATOM   3901 N  N     . VAL B 1 230 ? -15.731 -28.334 -44.397 1.00 52.80  ? 239 VAL B N     1 
ATOM   3902 C  CA    . VAL B 1 230 ? -15.729 -28.111 -42.923 1.00 48.24  ? 239 VAL B CA    1 
ATOM   3903 C  C     . VAL B 1 230 ? -17.171 -27.822 -42.565 1.00 40.00  ? 239 VAL B C     1 
ATOM   3904 O  O     . VAL B 1 230 ? -17.643 -26.758 -42.930 1.00 50.07  ? 239 VAL B O     1 
ATOM   3905 C  CB    . VAL B 1 230 ? -14.816 -26.944 -42.515 1.00 44.99  ? 239 VAL B CB    1 
ATOM   3906 C  CG1   . VAL B 1 230 ? -14.836 -26.726 -41.016 1.00 43.76  ? 239 VAL B CG1   1 
ATOM   3907 C  CG2   . VAL B 1 230 ? -13.414 -27.143 -43.038 1.00 45.73  ? 239 VAL B CG2   1 
ATOM   3908 N  N     . ASN B 1 231 ? -17.853 -28.786 -41.982 1.00 46.24  ? 240 ASN B N     1 
ATOM   3909 C  CA    . ASN B 1 231 ? -19.307 -28.698 -41.707 1.00 52.35  ? 240 ASN B CA    1 
ATOM   3910 C  C     . ASN B 1 231 ? -19.649 -29.630 -40.545 1.00 48.09  ? 240 ASN B C     1 
ATOM   3911 O  O     . ASN B 1 231 ? -19.053 -30.704 -40.478 1.00 47.84  ? 240 ASN B O     1 
ATOM   3912 C  CB    . ASN B 1 231 ? -20.120 -29.042 -42.957 1.00 53.44  ? 240 ASN B CB    1 
ATOM   3913 C  CG    . ASN B 1 231 ? -21.368 -28.190 -43.059 1.00 53.96  ? 240 ASN B CG    1 
ATOM   3914 O  OD1   . ASN B 1 231 ? -21.288 -26.974 -43.190 1.00 54.58  ? 240 ASN B OD1   1 
ATOM   3915 N  ND2   . ASN B 1 231 ? -22.525 -28.807 -42.951 1.00 57.89  ? 240 ASN B ND2   1 
ATOM   3916 N  N     . LEU B 1 232 ? -20.560 -29.226 -39.666 1.00 44.55  ? 241 LEU B N     1 
ATOM   3917 C  CA    . LEU B 1 232 ? -21.019 -30.104 -38.561 1.00 56.33  ? 241 LEU B CA    1 
ATOM   3918 C  C     . LEU B 1 232 ? -21.935 -31.213 -39.130 1.00 60.42  ? 241 LEU B C     1 
ATOM   3919 O  O     . LEU B 1 232 ? -21.912 -32.336 -38.618 1.00 64.34  ? 241 LEU B O     1 
ATOM   3920 C  CB    . LEU B 1 232 ? -21.736 -29.250 -37.510 1.00 59.56  ? 241 LEU B CB    1 
ATOM   3921 C  CG    . LEU B 1 232 ? -20.876 -28.578 -36.440 1.00 57.19  ? 241 LEU B CG    1 
ATOM   3922 C  CD1   . LEU B 1 232 ? -21.768 -27.811 -35.477 1.00 61.74  ? 241 LEU B CD1   1 
ATOM   3923 C  CD2   . LEU B 1 232 ? -20.043 -29.575 -35.660 1.00 57.48  ? 241 LEU B CD2   1 
ATOM   3924 N  N     . GLN B 1 233 ? -22.728 -30.904 -40.154 1.00 63.34  ? 242 GLN B N     1 
ATOM   3925 C  CA    . GLN B 1 233 ? -23.660 -31.861 -40.796 1.00 55.32  ? 242 GLN B CA    1 
ATOM   3926 C  C     . GLN B 1 233 ? -23.033 -32.410 -42.065 1.00 62.94  ? 242 GLN B C     1 
ATOM   3927 O  O     . GLN B 1 233 ? -22.129 -31.806 -42.636 1.00 61.38  ? 242 GLN B O     1 
ATOM   3928 C  CB    . GLN B 1 233 ? -24.944 -31.160 -41.200 1.00 56.59  ? 242 GLN B CB    1 
ATOM   3929 C  CG    . GLN B 1 233 ? -25.796 -30.758 -40.011 1.00 56.43  ? 242 GLN B CG    1 
ATOM   3930 C  CD    . GLN B 1 233 ? -27.074 -30.176 -40.541 1.00 53.81  ? 242 GLN B CD    1 
ATOM   3931 O  OE1   . GLN B 1 233 ? -27.071 -29.485 -41.557 1.00 66.96  ? 242 GLN B OE1   1 
ATOM   3932 N  NE2   . GLN B 1 233 ? -28.177 -30.484 -39.888 1.00 58.82  ? 242 GLN B NE2   1 
ATOM   3933 N  N     . PRO B 1 234 ? -23.532 -33.564 -42.551 1.00 64.16  ? 243 PRO B N     1 
ATOM   3934 C  CA    . PRO B 1 234 ? -23.223 -34.018 -43.900 1.00 57.19  ? 243 PRO B CA    1 
ATOM   3935 C  C     . PRO B 1 234 ? -23.578 -32.928 -44.908 1.00 55.02  ? 243 PRO B C     1 
ATOM   3936 O  O     . PRO B 1 234 ? -24.433 -32.163 -44.630 1.00 62.18  ? 243 PRO B O     1 
ATOM   3937 C  CB    . PRO B 1 234 ? -24.152 -35.213 -44.116 1.00 64.55  ? 243 PRO B CB    1 
ATOM   3938 C  CG    . PRO B 1 234 ? -24.522 -35.685 -42.711 1.00 65.18  ? 243 PRO B CG    1 
ATOM   3939 C  CD    . PRO B 1 234 ? -24.448 -34.461 -41.828 1.00 64.95  ? 243 PRO B CD    1 
ATOM   3940 N  N     . THR B 1 235 ? -22.904 -32.913 -46.052 1.00 62.43  ? 244 THR B N     1 
ATOM   3941 C  CA    . THR B 1 235 ? -23.158 -31.988 -47.184 1.00 58.40  ? 244 THR B CA    1 
ATOM   3942 C  C     . THR B 1 235 ? -23.548 -32.815 -48.408 1.00 57.89  ? 244 THR B C     1 
ATOM   3943 O  O     . THR B 1 235 ? -23.305 -34.044 -48.409 1.00 61.16  ? 244 THR B O     1 
ATOM   3944 C  CB    . THR B 1 235 ? -21.915 -31.140 -47.514 1.00 62.25  ? 244 THR B CB    1 
ATOM   3945 O  OG1   . THR B 1 235 ? -20.907 -31.963 -48.107 1.00 58.47  ? 244 THR B OG1   1 
ATOM   3946 C  CG2   . THR B 1 235 ? -21.311 -30.449 -46.310 1.00 60.35  ? 244 THR B CG2   1 
ATOM   3947 N  N     . LYS B 1 236 ? -24.061 -32.134 -49.427 1.00 58.01  ? 245 LYS B N     1 
ATOM   3948 C  CA    . LYS B 1 236 ? -24.434 -32.711 -50.743 1.00 59.12  ? 245 LYS B CA    1 
ATOM   3949 C  C     . LYS B 1 236 ? -23.232 -33.415 -51.385 1.00 57.97  ? 245 LYS B C     1 
ATOM   3950 O  O     . LYS B 1 236 ? -23.438 -34.416 -52.059 1.00 57.26  ? 245 LYS B O     1 
ATOM   3951 C  CB    . LYS B 1 236 ? -24.980 -31.594 -51.634 1.00 64.66  ? 245 LYS B CB    1 
ATOM   3952 C  CG    . LYS B 1 236 ? -25.348 -32.022 -53.044 1.00 68.21  ? 245 LYS B CG    1 
ATOM   3953 C  CD    . LYS B 1 236 ? -26.710 -31.560 -53.446 1.00 67.09  ? 245 LYS B CD    1 
ATOM   3954 C  CE    . LYS B 1 236 ? -26.912 -31.583 -54.940 1.00 68.76  ? 245 LYS B CE    1 
ATOM   3955 N  NZ    . LYS B 1 236 ? -27.744 -30.432 -55.346 1.00 75.91  ? 245 LYS B NZ    1 
ATOM   3956 N  N     . HIS B 1 237 ? -22.009 -32.943 -51.156 1.00 62.24  ? 246 HIS B N     1 
ATOM   3957 C  CA    . HIS B 1 237 ? -20.839 -33.350 -51.974 1.00 60.00  ? 246 HIS B CA    1 
ATOM   3958 C  C     . HIS B 1 237 ? -19.775 -34.062 -51.133 1.00 58.95  ? 246 HIS B C     1 
ATOM   3959 O  O     . HIS B 1 237 ? -18.674 -34.259 -51.662 1.00 62.89  ? 246 HIS B O     1 
ATOM   3960 C  CB    . HIS B 1 237 ? -20.324 -32.132 -52.758 1.00 65.43  ? 246 HIS B CB    1 
ATOM   3961 C  CG    . HIS B 1 237 ? -21.232 -31.708 -53.870 1.00 66.09  ? 246 HIS B CG    1 
ATOM   3962 N  ND1   . HIS B 1 237 ? -21.723 -30.423 -53.980 1.00 66.16  ? 246 HIS B ND1   1 
ATOM   3963 C  CD2   . HIS B 1 237 ? -21.761 -32.403 -54.900 1.00 66.51  ? 246 HIS B CD2   1 
ATOM   3964 C  CE1   . HIS B 1 237 ? -22.495 -30.342 -55.045 1.00 68.15  ? 246 HIS B CE1   1 
ATOM   3965 N  NE2   . HIS B 1 237 ? -22.535 -31.545 -55.623 1.00 66.64  ? 246 HIS B NE2   1 
ATOM   3966 N  N     . ASP B 1 238 ? -20.105 -34.525 -49.923 1.00 58.89  ? 247 ASP B N     1 
ATOM   3967 C  CA    . ASP B 1 238 ? -19.143 -35.218 -49.015 1.00 61.32  ? 247 ASP B CA    1 
ATOM   3968 C  C     . ASP B 1 238 ? -18.231 -36.205 -49.783 1.00 63.10  ? 247 ASP B C     1 
ATOM   3969 O  O     . ASP B 1 238 ? -17.025 -36.246 -49.438 1.00 63.71  ? 247 ASP B O     1 
ATOM   3970 C  CB    . ASP B 1 238 ? -19.872 -35.868 -47.833 1.00 59.77  ? 247 ASP B CB    1 
ATOM   3971 C  CG    . ASP B 1 238 ? -20.466 -34.883 -46.825 1.00 62.92  ? 247 ASP B CG    1 
ATOM   3972 O  OD1   . ASP B 1 238 ? -20.019 -33.726 -46.763 1.00 63.85  ? 247 ASP B OD1   1 
ATOM   3973 O  OD2   . ASP B 1 238 ? -21.362 -35.277 -46.086 1.00 59.23  ? 247 ASP B OD2   1 
ATOM   3974 N  N     . ARG B 1 239 ? -18.729 -36.948 -50.790 1.00 67.41  ? 248 ARG B N     1 
ATOM   3975 C  CA    . ARG B 1 239 ? -17.954 -38.025 -51.495 1.00 66.52  ? 248 ARG B CA    1 
ATOM   3976 C  C     . ARG B 1 239 ? -16.881 -37.432 -52.422 1.00 67.31  ? 248 ARG B C     1 
ATOM   3977 O  O     . ARG B 1 239 ? -15.897 -38.136 -52.680 1.00 71.21  ? 248 ARG B O     1 
ATOM   3978 C  CB    . ARG B 1 239 ? -18.857 -39.004 -52.262 1.00 76.56  ? 248 ARG B CB    1 
ATOM   3979 C  CG    . ARG B 1 239 ? -19.378 -38.531 -53.614 1.00 88.65  ? 248 ARG B CG    1 
ATOM   3980 C  CD    . ARG B 1 239 ? -20.736 -39.145 -53.961 1.00 97.21  ? 248 ARG B CD    1 
ATOM   3981 N  NE    . ARG B 1 239 ? -21.345 -38.650 -55.200 1.00 101.64 ? 248 ARG B NE    1 
ATOM   3982 C  CZ    . ARG B 1 239 ? -21.875 -37.431 -55.383 1.00 106.78 ? 248 ARG B CZ    1 
ATOM   3983 N  NH1   . ARG B 1 239 ? -22.400 -37.105 -56.555 1.00 93.35  ? 248 ARG B NH1   1 
ATOM   3984 N  NH2   . ARG B 1 239 ? -21.866 -36.531 -54.411 1.00 111.10 ? 248 ARG B NH2   1 
ATOM   3985 N  N     . HIS B 1 240 ? -17.033 -36.184 -52.867 1.00 61.93  ? 249 HIS B N     1 
ATOM   3986 C  CA    . HIS B 1 240 ? -16.085 -35.506 -53.785 1.00 55.93  ? 249 HIS B CA    1 
ATOM   3987 C  C     . HIS B 1 240 ? -14.878 -34.936 -53.026 1.00 58.58  ? 249 HIS B C     1 
ATOM   3988 O  O     . HIS B 1 240 ? -13.846 -34.675 -53.672 1.00 52.55  ? 249 HIS B O     1 
ATOM   3989 C  CB    . HIS B 1 240 ? -16.829 -34.440 -54.592 1.00 62.42  ? 249 HIS B CB    1 
ATOM   3990 C  CG    . HIS B 1 240 ? -17.709 -34.998 -55.658 1.00 71.60  ? 249 HIS B CG    1 
ATOM   3991 N  ND1   . HIS B 1 240 ? -19.037 -34.650 -55.768 1.00 76.45  ? 249 HIS B ND1   1 
ATOM   3992 C  CD2   . HIS B 1 240 ? -17.451 -35.857 -56.669 1.00 75.17  ? 249 HIS B CD2   1 
ATOM   3993 C  CE1   . HIS B 1 240 ? -19.568 -35.280 -56.797 1.00 79.89  ? 249 HIS B CE1   1 
ATOM   3994 N  NE2   . HIS B 1 240 ? -18.619 -36.033 -57.358 1.00 81.06  ? 249 HIS B NE2   1 
ATOM   3995 N  N     . ALA B 1 241 ? -14.968 -34.755 -51.708 1.00 59.47  ? 250 ALA B N     1 
ATOM   3996 C  CA    . ALA B 1 241 ? -13.900 -34.125 -50.886 1.00 55.64  ? 250 ALA B CA    1 
ATOM   3997 C  C     . ALA B 1 241 ? -12.653 -35.012 -50.809 1.00 57.46  ? 250 ALA B C     1 
ATOM   3998 O  O     . ALA B 1 241 ? -12.782 -36.238 -50.834 1.00 62.72  ? 250 ALA B O     1 
ATOM   3999 C  CB    . ALA B 1 241 ? -14.409 -33.842 -49.496 1.00 53.37  ? 250 ALA B CB    1 
ATOM   4000 N  N     . ASP B 1 242 ? -11.488 -34.391 -50.619 1.00 58.30  ? 251 ASP B N     1 
ATOM   4001 C  CA    . ASP B 1 242 ? -10.231 -35.086 -50.236 1.00 55.12  ? 251 ASP B CA    1 
ATOM   4002 C  C     . ASP B 1 242 ? -10.112 -35.108 -48.715 1.00 58.22  ? 251 ASP B C     1 
ATOM   4003 O  O     . ASP B 1 242 ? -9.476  -36.023 -48.206 1.00 63.55  ? 251 ASP B O     1 
ATOM   4004 C  CB    . ASP B 1 242 ? -9.025  -34.398 -50.865 1.00 59.51  ? 251 ASP B CB    1 
ATOM   4005 C  CG    . ASP B 1 242 ? -9.127  -34.398 -52.374 1.00 65.01  ? 251 ASP B CG    1 
ATOM   4006 O  OD1   . ASP B 1 242 ? -9.056  -35.510 -52.969 1.00 72.75  ? 251 ASP B OD1   1 
ATOM   4007 O  OD2   . ASP B 1 242 ? -9.325  -33.311 -52.930 1.00 62.51  ? 251 ASP B OD2   1 
ATOM   4008 N  N     . LEU B 1 243 ? -10.685 -34.116 -48.026 1.00 59.89  ? 252 LEU B N     1 
ATOM   4009 C  CA    . LEU B 1 243 ? -10.675 -34.013 -46.545 1.00 62.04  ? 252 LEU B CA    1 
ATOM   4010 C  C     . LEU B 1 243 ? -12.039 -33.487 -46.096 1.00 57.42  ? 252 LEU B C     1 
ATOM   4011 O  O     . LEU B 1 243 ? -12.528 -32.537 -46.712 1.00 68.81  ? 252 LEU B O     1 
ATOM   4012 C  CB    . LEU B 1 243 ? -9.537  -33.085 -46.112 1.00 64.62  ? 252 LEU B CB    1 
ATOM   4013 C  CG    . LEU B 1 243 ? -9.299  -32.987 -44.603 1.00 67.57  ? 252 LEU B CG    1 
ATOM   4014 C  CD1   . LEU B 1 243 ? -8.678  -34.265 -44.046 1.00 58.50  ? 252 LEU B CD1   1 
ATOM   4015 C  CD2   . LEU B 1 243 ? -8.436  -31.777 -44.272 1.00 65.52  ? 252 LEU B CD2   1 
ATOM   4016 N  N     . ARG B 1 244 ? -12.641 -34.135 -45.103 1.00 56.20  ? 253 ARG B N     1 
ATOM   4017 C  CA    . ARG B 1 244 ? -13.911 -33.718 -44.461 1.00 55.35  ? 253 ARG B CA    1 
ATOM   4018 C  C     . ARG B 1 244 ? -13.595 -33.486 -42.985 1.00 55.20  ? 253 ARG B C     1 
ATOM   4019 O  O     . ARG B 1 244 ? -13.015 -34.392 -42.346 1.00 54.68  ? 253 ARG B O     1 
ATOM   4020 C  CB    . ARG B 1 244 ? -15.023 -34.754 -44.644 1.00 60.89  ? 253 ARG B CB    1 
ATOM   4021 C  CG    . ARG B 1 244 ? -15.680 -34.768 -46.022 1.00 70.99  ? 253 ARG B CG    1 
ATOM   4022 C  CD    . ARG B 1 244 ? -16.595 -35.978 -46.275 1.00 77.68  ? 253 ARG B CD    1 
ATOM   4023 N  NE    . ARG B 1 244 ? -15.909 -37.235 -45.971 1.00 77.26  ? 253 ARG B NE    1 
ATOM   4024 C  CZ    . ARG B 1 244 ? -15.108 -37.918 -46.799 1.00 79.95  ? 253 ARG B CZ    1 
ATOM   4025 N  NH1   . ARG B 1 244 ? -14.501 -39.005 -46.352 1.00 73.22  ? 253 ARG B NH1   1 
ATOM   4026 N  NH2   . ARG B 1 244 ? -14.924 -37.546 -48.059 1.00 85.26  ? 253 ARG B NH2   1 
ATOM   4027 N  N     . ILE B 1 245 ? -13.911 -32.293 -42.488 1.00 52.85  ? 254 ILE B N     1 
ATOM   4028 C  CA    . ILE B 1 245 ? -13.648 -31.893 -41.077 1.00 50.01  ? 254 ILE B CA    1 
ATOM   4029 C  C     . ILE B 1 245 ? -14.993 -31.563 -40.432 1.00 52.91  ? 254 ILE B C     1 
ATOM   4030 O  O     . ILE B 1 245 ? -15.613 -30.549 -40.829 1.00 58.39  ? 254 ILE B O     1 
ATOM   4031 C  CB    . ILE B 1 245 ? -12.644 -30.733 -41.007 1.00 51.01  ? 254 ILE B CB    1 
ATOM   4032 C  CG1   . ILE B 1 245 ? -11.547 -30.881 -42.071 1.00 58.28  ? 254 ILE B CG1   1 
ATOM   4033 C  CG2   . ILE B 1 245 ? -12.068 -30.615 -39.607 1.00 59.01  ? 254 ILE B CG2   1 
ATOM   4034 C  CD1   . ILE B 1 245 ? -10.383 -29.899 -41.948 1.00 55.13  ? 254 ILE B CD1   1 
ATOM   4035 N  N     . HIS B 1 246 ? -15.420 -32.428 -39.508 1.00 51.76  ? 255 HIS B N     1 
ATOM   4036 C  CA    . HIS B 1 246 ? -16.657 -32.313 -38.696 1.00 51.97  ? 255 HIS B CA    1 
ATOM   4037 C  C     . HIS B 1 246 ? -16.286 -31.696 -37.326 1.00 48.58  ? 255 HIS B C     1 
ATOM   4038 O  O     . HIS B 1 246 ? -16.013 -32.437 -36.345 1.00 48.88  ? 255 HIS B O     1 
ATOM   4039 C  CB    . HIS B 1 246 ? -17.385 -33.675 -38.640 1.00 48.46  ? 255 HIS B CB    1 
ATOM   4040 C  CG    . HIS B 1 246 ? -17.679 -34.299 -39.969 1.00 53.90  ? 255 HIS B CG    1 
ATOM   4041 N  ND1   . HIS B 1 246 ? -17.002 -35.433 -40.424 1.00 51.28  ? 255 HIS B ND1   1 
ATOM   4042 C  CD2   . HIS B 1 246 ? -18.597 -33.983 -40.923 1.00 51.19  ? 255 HIS B CD2   1 
ATOM   4043 C  CE1   . HIS B 1 246 ? -17.473 -35.761 -41.618 1.00 62.91  ? 255 HIS B CE1   1 
ATOM   4044 N  NE2   . HIS B 1 246 ? -18.473 -34.887 -41.941 1.00 54.87  ? 255 HIS B NE2   1 
ATOM   4045 N  N     . GLY B 1 247 ? -16.318 -30.368 -37.269 1.00 46.31  ? 256 GLY B N     1 
ATOM   4046 C  CA    . GLY B 1 247 ? -16.064 -29.544 -36.076 1.00 47.11  ? 256 GLY B CA    1 
ATOM   4047 C  C     . GLY B 1 247 ? -16.573 -28.130 -36.295 1.00 47.39  ? 256 GLY B C     1 
ATOM   4048 O  O     . GLY B 1 247 ? -16.985 -27.824 -37.442 1.00 37.98  ? 256 GLY B O     1 
ATOM   4049 N  N     . TYR B 1 248 ? -16.613 -27.326 -35.223 1.00 44.31  ? 257 TYR B N     1 
ATOM   4050 C  CA    . TYR B 1 248 ? -16.907 -25.872 -35.272 1.00 44.87  ? 257 TYR B CA    1 
ATOM   4051 C  C     . TYR B 1 248 ? -15.820 -25.178 -36.103 1.00 48.95  ? 257 TYR B C     1 
ATOM   4052 O  O     . TYR B 1 248 ? -14.602 -25.315 -35.788 1.00 49.87  ? 257 TYR B O     1 
ATOM   4053 C  CB    . TYR B 1 248 ? -17.046 -25.323 -33.849 1.00 47.74  ? 257 TYR B CB    1 
ATOM   4054 C  CG    . TYR B 1 248 ? -18.150 -25.958 -33.032 1.00 47.42  ? 257 TYR B CG    1 
ATOM   4055 C  CD1   . TYR B 1 248 ? -19.483 -25.637 -33.253 1.00 45.67  ? 257 TYR B CD1   1 
ATOM   4056 C  CD2   . TYR B 1 248 ? -17.864 -26.857 -32.016 1.00 43.70  ? 257 TYR B CD2   1 
ATOM   4057 C  CE1   . TYR B 1 248 ? -20.507 -26.175 -32.483 1.00 43.04  ? 257 TYR B CE1   1 
ATOM   4058 C  CE2   . TYR B 1 248 ? -18.874 -27.397 -31.230 1.00 48.23  ? 257 TYR B CE2   1 
ATOM   4059 C  CZ    . TYR B 1 248 ? -20.199 -27.066 -31.473 1.00 46.25  ? 257 TYR B CZ    1 
ATOM   4060 O  OH    . TYR B 1 248 ? -21.193 -27.630 -30.736 1.00 45.19  ? 257 TYR B OH    1 
ATOM   4061 N  N     . VAL B 1 249 ? -16.226 -24.493 -37.176 1.00 47.81  ? 258 VAL B N     1 
ATOM   4062 C  CA    . VAL B 1 249 ? -15.292 -23.717 -38.047 1.00 50.19  ? 258 VAL B CA    1 
ATOM   4063 C  C     . VAL B 1 249 ? -14.392 -22.812 -37.192 1.00 49.18  ? 258 VAL B C     1 
ATOM   4064 O  O     . VAL B 1 249 ? -13.198 -22.673 -37.542 1.00 49.39  ? 258 VAL B O     1 
ATOM   4065 C  CB    . VAL B 1 249 ? -16.022 -22.885 -39.117 1.00 52.86  ? 258 VAL B CB    1 
ATOM   4066 C  CG1   . VAL B 1 249 ? -16.532 -23.759 -40.252 1.00 50.77  ? 258 VAL B CG1   1 
ATOM   4067 C  CG2   . VAL B 1 249 ? -17.137 -22.020 -38.530 1.00 47.19  ? 258 VAL B CG2   1 
ATOM   4068 N  N     . ASP B 1 250 ? -14.901 -22.211 -36.116 1.00 49.62  ? 259 ASP B N     1 
ATOM   4069 C  CA    . ASP B 1 250 ? -14.068 -21.300 -35.277 1.00 51.17  ? 259 ASP B CA    1 
ATOM   4070 C  C     . ASP B 1 250 ? -12.897 -22.091 -34.687 1.00 48.31  ? 259 ASP B C     1 
ATOM   4071 O  O     . ASP B 1 250 ? -11.755 -21.697 -34.890 1.00 46.33  ? 259 ASP B O     1 
ATOM   4072 C  CB    . ASP B 1 250 ? -14.883 -20.618 -34.183 1.00 55.06  ? 259 ASP B CB    1 
ATOM   4073 C  CG    . ASP B 1 250 ? -15.517 -19.306 -34.613 1.00 50.79  ? 259 ASP B CG    1 
ATOM   4074 O  OD1   . ASP B 1 250 ? -15.166 -18.821 -35.714 1.00 49.34  ? 259 ASP B OD1   1 
ATOM   4075 O  OD2   . ASP B 1 250 ? -16.347 -18.776 -33.834 1.00 39.27  ? 259 ASP B OD2   1 
ATOM   4076 N  N     . GLU B 1 251 ? -13.176 -23.189 -34.001 1.00 48.32  ? 260 GLU B N     1 
ATOM   4077 C  CA    . GLU B 1 251 ? -12.135 -24.123 -33.505 1.00 48.78  ? 260 GLU B CA    1 
ATOM   4078 C  C     . GLU B 1 251 ? -11.190 -24.525 -34.662 1.00 50.89  ? 260 GLU B C     1 
ATOM   4079 O  O     . GLU B 1 251 ? -9.966  -24.545 -34.461 1.00 46.99  ? 260 GLU B O     1 
ATOM   4080 C  CB    . GLU B 1 251 ? -12.831 -25.327 -32.869 1.00 54.84  ? 260 GLU B CB    1 
ATOM   4081 C  CG    . GLU B 1 251 ? -11.882 -26.464 -32.550 1.00 64.68  ? 260 GLU B CG    1 
ATOM   4082 C  CD    . GLU B 1 251 ? -12.405 -27.460 -31.539 1.00 66.09  ? 260 GLU B CD    1 
ATOM   4083 O  OE1   . GLU B 1 251 ? -13.597 -27.814 -31.621 1.00 83.30  ? 260 GLU B OE1   1 
ATOM   4084 O  OE2   . GLU B 1 251 ? -11.609 -27.891 -30.692 1.00 71.92  ? 260 GLU B OE2   1 
ATOM   4085 N  N     . VAL B 1 252 ? -11.715 -24.864 -35.842 1.00 53.66  ? 261 VAL B N     1 
ATOM   4086 C  CA    . VAL B 1 252 ? -10.883 -25.346 -36.989 1.00 45.48  ? 261 VAL B CA    1 
ATOM   4087 C  C     . VAL B 1 252 ? -9.970  -24.208 -37.432 1.00 41.95  ? 261 VAL B C     1 
ATOM   4088 O  O     . VAL B 1 252 ? -8.724  -24.406 -37.575 1.00 47.21  ? 261 VAL B O     1 
ATOM   4089 C  CB    . VAL B 1 252 ? -11.759 -25.872 -38.138 1.00 52.35  ? 261 VAL B CB    1 
ATOM   4090 C  CG1   . VAL B 1 252 ? -10.975 -25.989 -39.431 1.00 52.66  ? 261 VAL B CG1   1 
ATOM   4091 C  CG2   . VAL B 1 252 ? -12.406 -27.209 -37.773 1.00 51.51  ? 261 VAL B CG2   1 
ATOM   4092 N  N     . MET B 1 253 ? -10.553 -23.036 -37.601 1.00 40.25  ? 262 MET B N     1 
ATOM   4093 C  CA    . MET B 1 253 ? -9.860  -21.869 -38.195 1.00 43.63  ? 262 MET B CA    1 
ATOM   4094 C  C     . MET B 1 253 ? -8.822  -21.307 -37.217 1.00 44.29  ? 262 MET B C     1 
ATOM   4095 O  O     . MET B 1 253 ? -7.806  -20.808 -37.697 1.00 54.02  ? 262 MET B O     1 
ATOM   4096 C  CB    . MET B 1 253 ? -10.889 -20.800 -38.577 1.00 45.86  ? 262 MET B CB    1 
ATOM   4097 C  CG    . MET B 1 253 ? -11.729 -21.202 -39.791 1.00 47.54  ? 262 MET B CG    1 
ATOM   4098 S  SD    . MET B 1 253 ? -10.756 -21.630 -41.253 1.00 51.85  ? 262 MET B SD    1 
ATOM   4099 C  CE    . MET B 1 253 ? -10.359 -20.014 -41.917 1.00 49.14  ? 262 MET B CE    1 
ATOM   4100 N  N     . THR B 1 254 ? -9.059  -21.366 -35.906 1.00 45.66  ? 263 THR B N     1 
ATOM   4101 C  CA    . THR B 1 254 ? -8.079  -20.906 -34.890 1.00 48.88  ? 263 THR B CA    1 
ATOM   4102 C  C     . THR B 1 254 ? -6.912  -21.895 -34.832 1.00 53.62  ? 263 THR B C     1 
ATOM   4103 O  O     . THR B 1 254 ? -5.759  -21.415 -34.751 1.00 52.11  ? 263 THR B O     1 
ATOM   4104 C  CB    . THR B 1 254 ? -8.657  -20.686 -33.481 1.00 48.81  ? 263 THR B CB    1 
ATOM   4105 O  OG1   . THR B 1 254 ? -9.115  -21.928 -32.970 1.00 55.08  ? 263 THR B OG1   1 
ATOM   4106 C  CG2   . THR B 1 254 ? -9.779  -19.675 -33.420 1.00 51.63  ? 263 THR B CG2   1 
ATOM   4107 N  N     . ARG B 1 255 ? -7.184  -23.206 -34.846 1.00 48.84  ? 264 ARG B N     1 
ATOM   4108 C  CA    . ARG B 1 255 ? -6.092  -24.212 -34.937 1.00 54.42  ? 264 ARG B CA    1 
ATOM   4109 C  C     . ARG B 1 255 ? -5.262  -23.951 -36.204 1.00 53.07  ? 264 ARG B C     1 
ATOM   4110 O  O     . ARG B 1 255 ? -4.015  -23.945 -36.092 1.00 47.03  ? 264 ARG B O     1 
ATOM   4111 C  CB    . ARG B 1 255 ? -6.637  -25.636 -34.883 1.00 56.49  ? 264 ARG B CB    1 
ATOM   4112 C  CG    . ARG B 1 255 ? -7.059  -26.050 -33.481 1.00 59.12  ? 264 ARG B CG    1 
ATOM   4113 C  CD    . ARG B 1 255 ? -7.972  -27.262 -33.412 1.00 61.05  ? 264 ARG B CD    1 
ATOM   4114 N  NE    . ARG B 1 255 ? -8.054  -27.625 -32.008 1.00 73.76  ? 264 ARG B NE    1 
ATOM   4115 C  CZ    . ARG B 1 255 ? -8.306  -28.834 -31.518 1.00 89.93  ? 264 ARG B CZ    1 
ATOM   4116 N  NH1   . ARG B 1 255 ? -8.542  -29.869 -32.311 1.00 96.20  ? 264 ARG B NH1   1 
ATOM   4117 N  NH2   . ARG B 1 255 ? -8.310  -28.996 -30.206 1.00 97.11  ? 264 ARG B NH2   1 
ATOM   4118 N  N     . LEU B 1 256 ? -5.929  -23.705 -37.343 1.00 50.68  ? 265 LEU B N     1 
ATOM   4119 C  CA    . LEU B 1 256 ? -5.280  -23.506 -38.662 1.00 45.67  ? 265 LEU B CA    1 
ATOM   4120 C  C     . LEU B 1 256 ? -4.336  -22.299 -38.623 1.00 48.77  ? 265 LEU B C     1 
ATOM   4121 O  O     . LEU B 1 256 ? -3.163  -22.465 -39.024 1.00 55.99  ? 265 LEU B O     1 
ATOM   4122 C  CB    . LEU B 1 256 ? -6.337  -23.304 -39.743 1.00 43.09  ? 265 LEU B CB    1 
ATOM   4123 C  CG    . LEU B 1 256 ? -5.769  -23.086 -41.137 1.00 46.05  ? 265 LEU B CG    1 
ATOM   4124 C  CD1   . LEU B 1 256 ? -4.927  -24.278 -41.555 1.00 52.03  ? 265 LEU B CD1   1 
ATOM   4125 C  CD2   . LEU B 1 256 ? -6.869  -22.823 -42.155 1.00 50.07  ? 265 LEU B CD2   1 
ATOM   4126 N  N     . MET B 1 257 ? -4.812  -21.141 -38.174 1.00 47.07  ? 266 MET B N     1 
ATOM   4127 C  CA    . MET B 1 257 ? -3.995  -19.901 -38.095 1.00 50.40  ? 266 MET B CA    1 
ATOM   4128 C  C     . MET B 1 257 ? -2.800  -20.152 -37.174 1.00 52.29  ? 266 MET B C     1 
ATOM   4129 O  O     . MET B 1 257 ? -1.645  -19.817 -37.588 1.00 52.67  ? 266 MET B O     1 
ATOM   4130 C  CB    . MET B 1 257 ? -4.804  -18.702 -37.588 1.00 49.62  ? 266 MET B CB    1 
ATOM   4131 C  CG    . MET B 1 257 ? -5.984  -18.360 -38.471 1.00 48.96  ? 266 MET B CG    1 
ATOM   4132 S  SD    . MET B 1 257 ? -5.520  -17.972 -40.165 1.00 50.64  ? 266 MET B SD    1 
ATOM   4133 C  CE    . MET B 1 257 ? -4.864  -16.321 -39.975 1.00 50.68  ? 266 MET B CE    1 
ATOM   4134 N  N     . LYS B 1 258 ? -3.028  -20.794 -36.027 1.00 51.32  ? 267 LYS B N     1 
ATOM   4135 C  CA    . LYS B 1 258 ? -1.914  -21.193 -35.123 1.00 57.12  ? 267 LYS B CA    1 
ATOM   4136 C  C     . LYS B 1 258 ? -0.863  -21.992 -35.914 1.00 48.53  ? 267 LYS B C     1 
ATOM   4137 O  O     . LYS B 1 258 ? 0.316   -21.626 -35.864 1.00 49.42  ? 267 LYS B O     1 
ATOM   4138 C  CB    . LYS B 1 258 ? -2.394  -21.949 -33.886 1.00 60.82  ? 267 LYS B CB    1 
ATOM   4139 C  CG    . LYS B 1 258 ? -1.297  -22.159 -32.858 1.00 74.17  ? 267 LYS B CG    1 
ATOM   4140 C  CD    . LYS B 1 258 ? -1.791  -22.667 -31.526 1.00 85.27  ? 267 LYS B CD    1 
ATOM   4141 C  CE    . LYS B 1 258 ? -0.656  -23.117 -30.628 1.00 83.19  ? 267 LYS B CE    1 
ATOM   4142 N  NZ    . LYS B 1 258 ? -1.004  -24.374 -29.929 1.00 80.79  ? 267 LYS B NZ    1 
ATOM   4143 N  N     . HIS B 1 259 ? -1.241  -23.023 -36.651 1.00 46.41  ? 268 HIS B N     1 
ATOM   4144 C  CA    . HIS B 1 259 ? -0.251  -23.854 -37.392 1.00 51.38  ? 268 HIS B CA    1 
ATOM   4145 C  C     . HIS B 1 259 ? 0.412   -23.038 -38.500 1.00 49.81  ? 268 HIS B C     1 
ATOM   4146 O  O     . HIS B 1 259 ? 1.508   -23.378 -38.898 1.00 53.46  ? 268 HIS B O     1 
ATOM   4147 C  CB    . HIS B 1 259 ? -0.898  -25.105 -37.986 1.00 59.92  ? 268 HIS B CB    1 
ATOM   4148 C  CG    . HIS B 1 259 ? -1.488  -26.005 -36.958 1.00 55.47  ? 268 HIS B CG    1 
ATOM   4149 N  ND1   . HIS B 1 259 ? -1.094  -25.964 -35.641 1.00 65.95  ? 268 HIS B ND1   1 
ATOM   4150 C  CD2   . HIS B 1 259 ? -2.416  -26.978 -37.058 1.00 59.35  ? 268 HIS B CD2   1 
ATOM   4151 C  CE1   . HIS B 1 259 ? -1.778  -26.861 -34.951 1.00 75.76  ? 268 HIS B CE1   1 
ATOM   4152 N  NE2   . HIS B 1 259 ? -2.592  -27.510 -35.807 1.00 69.31  ? 268 HIS B NE2   1 
ATOM   4153 N  N     . LEU B 1 260 ? -0.235  -21.987 -38.984 1.00 52.07  ? 269 LEU B N     1 
ATOM   4154 C  CA    . LEU B 1 260 ? 0.306   -21.165 -40.087 1.00 50.14  ? 269 LEU B CA    1 
ATOM   4155 C  C     . LEU B 1 260 ? 1.210   -20.076 -39.502 1.00 48.26  ? 269 LEU B C     1 
ATOM   4156 O  O     . LEU B 1 260 ? 1.900   -19.425 -40.295 1.00 50.91  ? 269 LEU B O     1 
ATOM   4157 C  CB    . LEU B 1 260 ? -0.849  -20.572 -40.904 1.00 47.38  ? 269 LEU B CB    1 
ATOM   4158 C  CG    . LEU B 1 260 ? -1.712  -21.567 -41.678 1.00 48.33  ? 269 LEU B CG    1 
ATOM   4159 C  CD1   . LEU B 1 260 ? -2.980  -20.901 -42.201 1.00 53.06  ? 269 LEU B CD1   1 
ATOM   4160 C  CD2   . LEU B 1 260 ? -0.943  -22.213 -42.812 1.00 53.34  ? 269 LEU B CD2   1 
ATOM   4161 N  N     . GLY B 1 261 ? 1.199   -19.898 -38.176 1.00 50.14  ? 270 GLY B N     1 
ATOM   4162 C  CA    . GLY B 1 261 ? 1.955   -18.858 -37.449 1.00 42.65  ? 270 GLY B CA    1 
ATOM   4163 C  C     . GLY B 1 261 ? 1.407   -17.475 -37.734 1.00 48.21  ? 270 GLY B C     1 
ATOM   4164 O  O     . GLY B 1 261 ? 2.228   -16.587 -38.000 1.00 56.54  ? 270 GLY B O     1 
ATOM   4165 N  N     . LEU B 1 262 ? 0.073   -17.313 -37.705 1.00 51.70  ? 271 LEU B N     1 
ATOM   4166 C  CA    . LEU B 1 262 ? -0.664  -16.071 -38.084 1.00 51.95  ? 271 LEU B CA    1 
ATOM   4167 C  C     . LEU B 1 262 ? -1.601  -15.640 -36.960 1.00 50.36  ? 271 LEU B C     1 
ATOM   4168 O  O     . LEU B 1 262 ? -2.410  -16.485 -36.531 1.00 58.59  ? 271 LEU B O     1 
ATOM   4169 C  CB    . LEU B 1 262 ? -1.483  -16.327 -39.352 1.00 52.37  ? 271 LEU B CB    1 
ATOM   4170 C  CG    . LEU B 1 262 ? -0.711  -16.332 -40.667 1.00 54.48  ? 271 LEU B CG    1 
ATOM   4171 C  CD1   . LEU B 1 262 ? -1.626  -16.681 -41.823 1.00 57.68  ? 271 LEU B CD1   1 
ATOM   4172 C  CD2   . LEU B 1 262 ? -0.060  -14.981 -40.925 1.00 59.77  ? 271 LEU B CD2   1 
ATOM   4173 N  N     . GLU B 1 263 ? -1.533  -14.379 -36.519 1.00 54.47  ? 272 GLU B N     1 
ATOM   4174 C  CA    . GLU B 1 263 ? -2.553  -13.819 -35.583 1.00 58.68  ? 272 GLU B CA    1 
ATOM   4175 C  C     . GLU B 1 263 ? -3.880  -13.590 -36.321 1.00 54.34  ? 272 GLU B C     1 
ATOM   4176 O  O     . GLU B 1 263 ? -3.895  -13.388 -37.544 1.00 54.60  ? 272 GLU B O     1 
ATOM   4177 C  CB    . GLU B 1 263 ? -2.092  -12.541 -34.881 1.00 67.96  ? 272 GLU B CB    1 
ATOM   4178 C  CG    . GLU B 1 263 ? -2.016  -11.287 -35.744 1.00 82.83  ? 272 GLU B CG    1 
ATOM   4179 C  CD    . GLU B 1 263 ? -1.528  -10.047 -34.989 1.00 91.13  ? 272 GLU B CD    1 
ATOM   4180 O  OE1   . GLU B 1 263 ? -2.138  -9.691  -33.947 1.00 77.24  ? 272 GLU B OE1   1 
ATOM   4181 O  OE2   . GLU B 1 263 ? -0.525  -9.445  -35.424 1.00 90.80  ? 272 GLU B OE2   1 
ATOM   4182 N  N     . ILE B 1 264 ? -4.963  -13.654 -35.569 1.00 57.12  ? 273 ILE B N     1 
ATOM   4183 C  CA    . ILE B 1 264 ? -6.316  -13.218 -35.998 1.00 55.15  ? 273 ILE B CA    1 
ATOM   4184 C  C     . ILE B 1 264 ? -6.444  -11.766 -35.568 1.00 58.89  ? 273 ILE B C     1 
ATOM   4185 O  O     . ILE B 1 264 ? -6.248  -11.424 -34.397 1.00 62.45  ? 273 ILE B O     1 
ATOM   4186 C  CB    . ILE B 1 264 ? -7.388  -14.141 -35.400 1.00 51.24  ? 273 ILE B CB    1 
ATOM   4187 C  CG1   . ILE B 1 264 ? -7.300  -15.504 -36.085 1.00 48.22  ? 273 ILE B CG1   1 
ATOM   4188 C  CG2   . ILE B 1 264 ? -8.769  -13.511 -35.486 1.00 56.35  ? 273 ILE B CG2   1 
ATOM   4189 C  CD1   . ILE B 1 264 ? -8.217  -16.570 -35.531 1.00 52.43  ? 273 ILE B CD1   1 
ATOM   4190 N  N     . PRO B 1 265 ? -6.667  -10.859 -36.532 1.00 59.13  ? 274 PRO B N     1 
ATOM   4191 C  CA    . PRO B 1 265 ? -6.686  -9.433  -36.249 1.00 56.05  ? 274 PRO B CA    1 
ATOM   4192 C  C     . PRO B 1 265 ? -7.932  -9.046  -35.455 1.00 54.95  ? 274 PRO B C     1 
ATOM   4193 O  O     . PRO B 1 265 ? -8.958  -9.668  -35.606 1.00 64.10  ? 274 PRO B O     1 
ATOM   4194 C  CB    . PRO B 1 265 ? -6.736  -8.768  -37.626 1.00 56.73  ? 274 PRO B CB    1 
ATOM   4195 C  CG    . PRO B 1 265 ? -6.415  -9.871  -38.610 1.00 56.51  ? 274 PRO B CG    1 
ATOM   4196 C  CD    . PRO B 1 265 ? -6.887  -11.146 -37.954 1.00 60.56  ? 274 PRO B CD    1 
ATOM   4197 N  N     . ALA B 1 266 ? -7.806  -7.988  -34.663 1.00 58.68  ? 275 ALA B N     1 
ATOM   4198 C  CA    . ALA B 1 266 ? -8.922  -7.348  -33.951 1.00 57.23  ? 275 ALA B CA    1 
ATOM   4199 C  C     . ALA B 1 266 ? -9.870  -6.740  -34.990 1.00 54.32  ? 275 ALA B C     1 
ATOM   4200 O  O     . ALA B 1 266 ? -9.412  -6.360  -36.077 1.00 54.37  ? 275 ALA B O     1 
ATOM   4201 C  CB    . ALA B 1 266 ? -8.378  -6.309  -33.001 1.00 65.79  ? 275 ALA B CB    1 
ATOM   4202 N  N     . TRP B 1 267 ? -11.146 -6.634  -34.639 1.00 54.34  ? 276 TRP B N     1 
ATOM   4203 C  CA    . TRP B 1 267 ? -12.175 -5.924  -35.433 1.00 59.27  ? 276 TRP B CA    1 
ATOM   4204 C  C     . TRP B 1 267 ? -12.326 -4.460  -34.980 1.00 67.33  ? 276 TRP B C     1 
ATOM   4205 O  O     . TRP B 1 267 ? -13.011 -4.196  -33.955 1.00 58.49  ? 276 TRP B O     1 
ATOM   4206 C  CB    . TRP B 1 267 ? -13.480 -6.694  -35.343 1.00 57.19  ? 276 TRP B CB    1 
ATOM   4207 C  CG    . TRP B 1 267 ? -14.542 -6.173  -36.245 1.00 50.89  ? 276 TRP B CG    1 
ATOM   4208 C  CD1   . TRP B 1 267 ? -14.500 -6.034  -37.599 1.00 50.60  ? 276 TRP B CD1   1 
ATOM   4209 C  CD2   . TRP B 1 267 ? -15.835 -5.735  -35.833 1.00 51.01  ? 276 TRP B CD2   1 
ATOM   4210 N  NE1   . TRP B 1 267 ? -15.684 -5.540  -38.063 1.00 42.92  ? 276 TRP B NE1   1 
ATOM   4211 C  CE2   . TRP B 1 267 ? -16.526 -5.352  -37.001 1.00 49.85  ? 276 TRP B CE2   1 
ATOM   4212 C  CE3   . TRP B 1 267 ? -16.461 -5.615  -34.595 1.00 52.23  ? 276 TRP B CE3   1 
ATOM   4213 C  CZ2   . TRP B 1 267 ? -17.836 -4.882  -36.961 1.00 50.61  ? 276 TRP B CZ2   1 
ATOM   4214 C  CZ3   . TRP B 1 267 ? -17.753 -5.136  -34.556 1.00 52.86  ? 276 TRP B CZ3   1 
ATOM   4215 C  CH2   . TRP B 1 267 ? -18.425 -4.774  -35.725 1.00 51.82  ? 276 TRP B CH2   1 
ATOM   4216 N  N     . ASP B 1 268 ? -11.748 -3.557  -35.781 1.00 72.05  ? 277 ASP B N     1 
ATOM   4217 C  CA    . ASP B 1 268 ? -11.833 -2.077  -35.678 1.00 75.85  ? 277 ASP B CA    1 
ATOM   4218 C  C     . ASP B 1 268 ? -13.295 -1.608  -35.549 1.00 73.01  ? 277 ASP B C     1 
ATOM   4219 O  O     . ASP B 1 268 ? -13.482 -0.458  -35.111 1.00 67.18  ? 277 ASP B O     1 
ATOM   4220 C  CB    . ASP B 1 268 ? -11.138 -1.432  -36.887 1.00 85.24  ? 277 ASP B CB    1 
ATOM   4221 C  CG    . ASP B 1 268 ? -9.632  -1.254  -36.722 1.00 88.70  ? 277 ASP B CG    1 
ATOM   4222 O  OD1   . ASP B 1 268 ? -9.192  -1.132  -35.562 1.00 82.84  ? 277 ASP B OD1   1 
ATOM   4223 O  OD2   . ASP B 1 268 ? -8.904  -1.231  -37.759 1.00 81.33  ? 277 ASP B OD2   1 
ATOM   4224 N  N     . GLY B 1 269 ? -14.281 -2.451  -35.899 1.00 70.22  ? 278 GLY B N     1 
ATOM   4225 C  CA    . GLY B 1 269 ? -15.708 -2.079  -36.040 1.00 60.08  ? 278 GLY B CA    1 
ATOM   4226 C  C     . GLY B 1 269 ? -16.115 -2.029  -37.512 1.00 54.01  ? 278 GLY B C     1 
ATOM   4227 O  O     . GLY B 1 269 ? -15.296 -2.301  -38.381 1.00 58.93  ? 278 GLY B O     1 
ATOM   4228 N  N     . PRO B 1 270 ? -17.376 -1.673  -37.850 1.00 54.64  ? 279 PRO B N     1 
ATOM   4229 C  CA    . PRO B 1 270 ? -17.860 -1.743  -39.236 1.00 53.33  ? 279 PRO B CA    1 
ATOM   4230 C  C     . PRO B 1 270 ? -17.061 -0.890  -40.222 1.00 52.83  ? 279 PRO B C     1 
ATOM   4231 O  O     . PRO B 1 270 ? -17.007 0.295   -39.994 1.00 48.42  ? 279 PRO B O     1 
ATOM   4232 C  CB    . PRO B 1 270 ? -19.284 -1.199  -39.217 1.00 54.57  ? 279 PRO B CB    1 
ATOM   4233 C  CG    . PRO B 1 270 ? -19.617 -0.930  -37.756 1.00 53.15  ? 279 PRO B CG    1 
ATOM   4234 C  CD    . PRO B 1 270 ? -18.403 -1.236  -36.906 1.00 52.16  ? 279 PRO B CD    1 
ATOM   4235 N  N     . ARG B 1 271 ? -16.446 -1.511  -41.239 1.00 51.95  ? 280 ARG B N     1 
ATOM   4236 C  CA    . ARG B 1 271 ? -15.511 -0.834  -42.186 1.00 53.78  ? 280 ARG B CA    1 
ATOM   4237 C  C     . ARG B 1 271 ? -15.648 -1.440  -43.584 1.00 52.75  ? 280 ARG B C     1 
ATOM   4238 O  O     . ARG B 1 271 ? -15.604 -2.679  -43.684 1.00 60.63  ? 280 ARG B O     1 
ATOM   4239 C  CB    . ARG B 1 271 ? -14.059 -0.988  -41.724 1.00 56.51  ? 280 ARG B CB    1 
ATOM   4240 C  CG    . ARG B 1 271 ? -13.678 -0.199  -40.480 1.00 58.44  ? 280 ARG B CG    1 
ATOM   4241 C  CD    . ARG B 1 271 ? -13.985 1.280   -40.602 1.00 64.83  ? 280 ARG B CD    1 
ATOM   4242 N  NE    . ARG B 1 271 ? -13.181 2.141   -39.745 1.00 69.99  ? 280 ARG B NE    1 
ATOM   4243 C  CZ    . ARG B 1 271 ? -13.216 2.157   -38.417 1.00 77.78  ? 280 ARG B CZ    1 
ATOM   4244 N  NH1   . ARG B 1 271 ? -13.986 1.320   -37.740 1.00 79.59  ? 280 ARG B NH1   1 
ATOM   4245 N  NH2   . ARG B 1 271 ? -12.441 2.997   -37.758 1.00 93.66  ? 280 ARG B NH2   1 
ATOM   4246 N  N     . VAL B 1 272 ? -15.809 -0.595  -44.611 1.00 51.02  ? 281 VAL B N     1 
ATOM   4247 C  CA    . VAL B 1 272 ? -15.839 -0.986  -46.051 1.00 43.13  ? 281 VAL B CA    1 
ATOM   4248 C  C     . VAL B 1 272 ? -14.447 -0.778  -46.655 1.00 43.19  ? 281 VAL B C     1 
ATOM   4249 O  O     . VAL B 1 272 ? -13.997 0.345   -46.635 1.00 44.22  ? 281 VAL B O     1 
ATOM   4250 C  CB    . VAL B 1 272 ? -16.865 -0.179  -46.860 1.00 47.32  ? 281 VAL B CB    1 
ATOM   4251 C  CG1   . VAL B 1 272 ? -17.019 -0.754  -48.263 1.00 47.24  ? 281 VAL B CG1   1 
ATOM   4252 C  CG2   . VAL B 1 272 ? -18.218 -0.075  -46.170 1.00 45.28  ? 281 VAL B CG2   1 
ATOM   4253 N  N     . LEU B 1 273 ? -13.827 -1.829  -47.209 1.00 46.18  ? 282 LEU B N     1 
ATOM   4254 C  CA    . LEU B 1 273 ? -12.619 -1.741  -48.066 1.00 44.52  ? 282 LEU B CA    1 
ATOM   4255 C  C     . LEU B 1 273 ? -12.983 -2.194  -49.484 1.00 44.82  ? 282 LEU B C     1 
ATOM   4256 O  O     . LEU B 1 273 ? -13.295 -3.363  -49.645 1.00 40.04  ? 282 LEU B O     1 
ATOM   4257 C  CB    . LEU B 1 273 ? -11.543 -2.650  -47.462 1.00 48.54  ? 282 LEU B CB    1 
ATOM   4258 C  CG    . LEU B 1 273 ? -10.176 -2.625  -48.154 1.00 41.53  ? 282 LEU B CG    1 
ATOM   4259 C  CD1   . LEU B 1 273 ? -9.609  -1.224  -48.213 1.00 43.45  ? 282 LEU B CD1   1 
ATOM   4260 C  CD2   . LEU B 1 273 ? -9.213  -3.541  -47.434 1.00 39.07  ? 282 LEU B CD2   1 
ATOM   4261 N  N     . GLU B 1 274 ? -13.002 -1.289  -50.459 1.00 51.13  ? 283 GLU B N     1 
ATOM   4262 C  CA    . GLU B 1 274 ? -13.448 -1.589  -51.848 1.00 52.73  ? 283 GLU B CA    1 
ATOM   4263 C  C     . GLU B 1 274 ? -12.397 -2.443  -52.559 1.00 50.48  ? 283 GLU B C     1 
ATOM   4264 O  O     . GLU B 1 274 ? -12.779 -3.494  -53.097 1.00 47.60  ? 283 GLU B O     1 
ATOM   4265 C  CB    . GLU B 1 274 ? -13.700 -0.305  -52.652 1.00 60.88  ? 283 GLU B CB    1 
ATOM   4266 C  CG    . GLU B 1 274 ? -14.905 0.502   -52.175 1.00 63.39  ? 283 GLU B CG    1 
ATOM   4267 C  CD    . GLU B 1 274 ? -16.225 -0.248  -52.194 1.00 65.42  ? 283 GLU B CD    1 
ATOM   4268 O  OE1   . GLU B 1 274 ? -16.324 -1.233  -52.949 1.00 69.12  ? 283 GLU B OE1   1 
ATOM   4269 O  OE2   . GLU B 1 274 ? -17.153 0.155   -51.456 1.00 61.86  ? 283 GLU B OE2   1 
ATOM   4270 N  N     . ARG B 1 275 ? -11.137 -1.986  -52.591 1.00 56.89  ? 284 ARG B N     1 
ATOM   4271 C  CA    . ARG B 1 275 ? -10.018 -2.640  -53.335 1.00 59.98  ? 284 ARG B CA    1 
ATOM   4272 C  C     . ARG B 1 275 ? -9.051  -3.261  -52.330 1.00 59.41  ? 284 ARG B C     1 
ATOM   4273 O  O     . ARG B 1 275 ? -8.763  -2.600  -51.322 1.00 60.79  ? 284 ARG B O     1 
ATOM   4274 C  CB    . ARG B 1 275 ? -9.230  -1.665  -54.220 1.00 59.75  ? 284 ARG B CB    1 
ATOM   4275 C  CG    . ARG B 1 275 ? -10.056 -0.934  -55.270 1.00 65.68  ? 284 ARG B CG    1 
ATOM   4276 C  CD    . ARG B 1 275 ? -9.429  -0.990  -56.653 1.00 71.06  ? 284 ARG B CD    1 
ATOM   4277 N  NE    . ARG B 1 275 ? -10.297 -0.450  -57.690 1.00 80.25  ? 284 ARG B NE    1 
ATOM   4278 C  CZ    . ARG B 1 275 ? -10.110 -0.572  -59.008 1.00 82.37  ? 284 ARG B CZ    1 
ATOM   4279 N  NH1   . ARG B 1 275 ? -9.073  -1.240  -59.489 1.00 77.34  ? 284 ARG B NH1   1 
ATOM   4280 N  NH2   . ARG B 1 275 ? -10.975 -0.018  -59.847 1.00 80.29  ? 284 ARG B NH2   1 
ATOM   4281 N  N     . ALA B 1 276 ? -8.558  -4.471  -52.617 1.00 58.84  ? 285 ALA B N     1 
ATOM   4282 C  CA    . ALA B 1 276 ? -7.529  -5.165  -51.805 1.00 60.97  ? 285 ALA B CA    1 
ATOM   4283 C  C     . ALA B 1 276 ? -6.222  -4.353  -51.798 1.00 64.07  ? 285 ALA B C     1 
ATOM   4284 O  O     . ALA B 1 276 ? -5.924  -3.711  -52.816 1.00 64.58  ? 285 ALA B O     1 
ATOM   4285 C  CB    . ALA B 1 276 ? -7.324  -6.566  -52.308 1.00 53.47  ? 285 ALA B CB    1 
ATOM   4286 N  N     . LEU B 1 277 ? -5.531  -4.320  -50.651 1.00 71.80  ? 286 LEU B N     1 
ATOM   4287 C  CA    . LEU B 1 277 ? -4.205  -3.665  -50.466 1.00 78.13  ? 286 LEU B CA    1 
ATOM   4288 C  C     . LEU B 1 277 ? -3.124  -4.684  -50.816 1.00 73.89  ? 286 LEU B C     1 
ATOM   4289 O  O     . LEU B 1 277 ? -3.352  -5.889  -50.755 1.00 68.80  ? 286 LEU B O     1 
ATOM   4290 C  CB    . LEU B 1 277 ? -4.061  -3.160  -49.022 1.00 71.74  ? 286 LEU B CB    1 
ATOM   4291 C  CG    . LEU B 1 277 ? -5.050  -2.074  -48.598 1.00 81.42  ? 286 LEU B CG    1 
ATOM   4292 C  CD1   . LEU B 1 277 ? -5.441  -2.196  -47.127 1.00 81.71  ? 286 LEU B CD1   1 
ATOM   4293 C  CD2   . LEU B 1 277 ? -4.493  -0.689  -48.878 1.00 85.77  ? 286 LEU B CD2   1 
ATOM   4294 N  N     . PRO B 1 278 ? -1.907  -4.240  -51.200 1.00 82.59  ? 287 PRO B N     1 
ATOM   4295 C  CA    . PRO B 1 278 ? -0.850  -5.172  -51.580 1.00 74.94  ? 287 PRO B CA    1 
ATOM   4296 C  C     . PRO B 1 278 ? -0.502  -6.066  -50.396 1.00 69.25  ? 287 PRO B C     1 
ATOM   4297 O  O     . PRO B 1 278 ? -0.733  -5.716  -49.235 1.00 59.75  ? 287 PRO B O     1 
ATOM   4298 C  CB    . PRO B 1 278 ? 0.321   -4.265  -51.977 1.00 77.37  ? 287 PRO B CB    1 
ATOM   4299 C  CG    . PRO B 1 278 ? 0.047   -2.984  -51.202 1.00 79.46  ? 287 PRO B CG    1 
ATOM   4300 C  CD    . PRO B 1 278 ? -1.459  -2.837  -51.256 1.00 84.41  ? 287 PRO B CD    1 
ATOM   4301 N  N     . PRO B 1 279 ? 0.086   -7.244  -50.673 1.00 61.32  ? 288 PRO B N     1 
ATOM   4302 C  CA    . PRO B 1 279 ? 0.230   -8.290  -49.657 1.00 58.16  ? 288 PRO B CA    1 
ATOM   4303 C  C     . PRO B 1 279 ? 1.266   -7.979  -48.550 1.00 61.12  ? 288 PRO B C     1 
ATOM   4304 O  O     . PRO B 1 279 ? 2.312   -7.363  -48.798 1.00 56.26  ? 288 PRO B O     1 
ATOM   4305 C  CB    . PRO B 1 279 ? 0.601   -9.550  -50.474 1.00 56.06  ? 288 PRO B CB    1 
ATOM   4306 C  CG    . PRO B 1 279 ? 0.458   -9.144  -51.938 1.00 61.01  ? 288 PRO B CG    1 
ATOM   4307 C  CD    . PRO B 1 279 ? 0.618   -7.634  -51.987 1.00 56.00  ? 288 PRO B CD    1 
ATOM   4308 N  N     . LEU B 1 280 ? 0.948   -8.410  -47.326 1.00 57.33  ? 289 LEU B N     1 
ATOM   4309 C  CA    . LEU B 1 280 ? 1.812   -8.234  -46.132 1.00 56.85  ? 289 LEU B CA    1 
ATOM   4310 C  C     . LEU B 1 280 ? 2.735   -9.445  -46.026 1.00 54.55  ? 289 LEU B C     1 
ATOM   4311 O  O     . LEU B 1 280 ? 2.511   -10.460 -46.675 1.00 48.65  ? 289 LEU B O     1 
ATOM   4312 C  CB    . LEU B 1 280 ? 0.914   -8.077  -44.903 1.00 61.21  ? 289 LEU B CB    1 
ATOM   4313 C  CG    . LEU B 1 280 ? -0.078  -6.912  -44.952 1.00 63.79  ? 289 LEU B CG    1 
ATOM   4314 C  CD1   . LEU B 1 280 ? -0.947  -6.905  -43.713 1.00 70.08  ? 289 LEU B CD1   1 
ATOM   4315 C  CD2   . LEU B 1 280 ? 0.625   -5.575  -45.086 1.00 64.65  ? 289 LEU B CD2   1 
ATOM   4316 N  N     . PRO B 1 281 ? 3.839   -9.369  -45.259 1.00 52.84  ? 290 PRO B N     1 
ATOM   4317 C  CA    . PRO B 1 281 ? 4.737   -10.514 -45.109 1.00 51.71  ? 290 PRO B CA    1 
ATOM   4318 C  C     . PRO B 1 281 ? 4.043   -11.687 -44.417 1.00 51.24  ? 290 PRO B C     1 
ATOM   4319 O  O     . PRO B 1 281 ? 3.194   -11.390 -43.595 1.00 58.59  ? 290 PRO B O     1 
ATOM   4320 C  CB    . PRO B 1 281 ? 5.867   -9.973  -44.217 1.00 52.90  ? 290 PRO B CB    1 
ATOM   4321 C  CG    . PRO B 1 281 ? 5.811   -8.469  -44.368 1.00 49.95  ? 290 PRO B CG    1 
ATOM   4322 C  CD    . PRO B 1 281 ? 4.350   -8.156  -44.602 1.00 52.86  ? 290 PRO B CD    1 
ATOM   4323 N  N     . ARG B 1 282 ? 4.422   -12.938 -44.731 1.00 44.88  ? 291 ARG B N     1 
ATOM   4324 C  CA    . ARG B 1 282 ? 3.919   -14.141 -44.018 1.00 47.31  ? 291 ARG B CA    1 
ATOM   4325 C  C     . ARG B 1 282 ? 5.066   -15.046 -43.584 1.00 47.67  ? 291 ARG B C     1 
ATOM   4326 O  O     . ARG B 1 282 ? 6.174   -14.960 -44.088 1.00 51.18  ? 291 ARG B O     1 
ATOM   4327 C  CB    . ARG B 1 282 ? 2.903   -14.940 -44.840 1.00 54.37  ? 291 ARG B CB    1 
ATOM   4328 C  CG    . ARG B 1 282 ? 3.359   -15.411 -46.214 1.00 57.03  ? 291 ARG B CG    1 
ATOM   4329 C  CD    . ARG B 1 282 ? 2.325   -16.347 -46.814 1.00 59.72  ? 291 ARG B CD    1 
ATOM   4330 N  NE    . ARG B 1 282 ? 2.755   -16.875 -48.108 1.00 69.45  ? 291 ARG B NE    1 
ATOM   4331 C  CZ    . ARG B 1 282 ? 2.477   -16.350 -49.304 1.00 63.60  ? 291 ARG B CZ    1 
ATOM   4332 N  NH1   . ARG B 1 282 ? 2.957   -16.923 -50.391 1.00 68.92  ? 291 ARG B NH1   1 
ATOM   4333 N  NH2   . ARG B 1 282 ? 1.708   -15.283 -49.430 1.00 65.00  ? 291 ARG B NH2   1 
ATOM   4334 N  N     . PRO B 1 283 ? 4.845   -15.935 -42.595 1.00 48.80  ? 292 PRO B N     1 
ATOM   4335 C  CA    . PRO B 1 283 ? 5.875   -16.897 -42.202 1.00 47.91  ? 292 PRO B CA    1 
ATOM   4336 C  C     . PRO B 1 283 ? 6.387   -17.730 -43.374 1.00 49.60  ? 292 PRO B C     1 
ATOM   4337 O  O     . PRO B 1 283 ? 5.681   -17.935 -44.347 1.00 48.71  ? 292 PRO B O     1 
ATOM   4338 C  CB    . PRO B 1 283 ? 5.144   -17.778 -41.176 1.00 42.88  ? 292 PRO B CB    1 
ATOM   4339 C  CG    . PRO B 1 283 ? 4.131   -16.836 -40.574 1.00 44.34  ? 292 PRO B CG    1 
ATOM   4340 C  CD    . PRO B 1 283 ? 3.645   -16.012 -41.744 1.00 46.76  ? 292 PRO B CD    1 
ATOM   4341 N  N     . PRO B 1 284 ? 7.651   -18.197 -43.347 1.00 53.62  ? 293 PRO B N     1 
ATOM   4342 C  CA    . PRO B 1 284 ? 8.114   -19.172 -44.327 1.00 54.42  ? 293 PRO B CA    1 
ATOM   4343 C  C     . PRO B 1 284 ? 7.458   -20.546 -44.108 1.00 60.56  ? 293 PRO B C     1 
ATOM   4344 O  O     . PRO B 1 284 ? 7.066   -20.835 -42.997 1.00 57.40  ? 293 PRO B O     1 
ATOM   4345 C  CB    . PRO B 1 284 ? 9.623   -19.242 -44.064 1.00 59.02  ? 293 PRO B CB    1 
ATOM   4346 C  CG    . PRO B 1 284 ? 9.749   -18.861 -42.611 1.00 56.85  ? 293 PRO B CG    1 
ATOM   4347 C  CD    . PRO B 1 284 ? 8.721   -17.764 -42.434 1.00 52.47  ? 293 PRO B CD    1 
ATOM   4348 N  N     . THR B 1 285 ? 7.405   -21.338 -45.181 1.00 58.59  ? 294 THR B N     1 
ATOM   4349 C  CA    . THR B 1 285 ? 6.752   -22.663 -45.290 1.00 62.61  ? 294 THR B CA    1 
ATOM   4350 C  C     . THR B 1 285 ? 7.584   -23.725 -44.587 1.00 59.53  ? 294 THR B C     1 
ATOM   4351 O  O     . THR B 1 285 ? 8.805   -23.718 -44.660 1.00 67.28  ? 294 THR B O     1 
ATOM   4352 C  CB    . THR B 1 285 ? 6.620   -23.101 -46.753 1.00 68.31  ? 294 THR B CB    1 
ATOM   4353 O  OG1   . THR B 1 285 ? 6.041   -22.033 -47.500 1.00 59.22  ? 294 THR B OG1   1 
ATOM   4354 C  CG2   . THR B 1 285 ? 5.787   -24.355 -46.920 1.00 77.19  ? 294 THR B CG2   1 
ATOM   4355 N  N     . PRO B 1 286 ? 6.954   -24.689 -43.890 1.00 57.36  ? 295 PRO B N     1 
ATOM   4356 C  CA    . PRO B 1 286 ? 7.683   -25.859 -43.402 1.00 60.55  ? 295 PRO B CA    1 
ATOM   4357 C  C     . PRO B 1 286 ? 8.274   -26.654 -44.575 1.00 56.16  ? 295 PRO B C     1 
ATOM   4358 O  O     . PRO B 1 286 ? 8.037   -26.308 -45.697 1.00 49.53  ? 295 PRO B O     1 
ATOM   4359 C  CB    . PRO B 1 286 ? 6.622   -26.684 -42.661 1.00 57.81  ? 295 PRO B CB    1 
ATOM   4360 C  CG    . PRO B 1 286 ? 5.514   -25.674 -42.349 1.00 54.70  ? 295 PRO B CG    1 
ATOM   4361 C  CD    . PRO B 1 286 ? 5.543   -24.684 -43.493 1.00 52.24  ? 295 PRO B CD    1 
ATOM   4362 N  N     . LYS B 1 287 ? 9.081   -27.664 -44.272 1.00 66.13  ? 296 LYS B N     1 
ATOM   4363 C  CA    . LYS B 1 287 ? 9.511   -28.675 -45.267 1.00 69.28  ? 296 LYS B CA    1 
ATOM   4364 C  C     . LYS B 1 287 ? 8.399   -29.709 -45.335 1.00 70.46  ? 296 LYS B C     1 
ATOM   4365 O  O     . LYS B 1 287 ? 7.845   -30.028 -44.276 1.00 71.56  ? 296 LYS B O     1 
ATOM   4366 C  CB    . LYS B 1 287 ? 10.833  -29.325 -44.863 1.00 74.08  ? 296 LYS B CB    1 
ATOM   4367 C  CG    . LYS B 1 287 ? 12.044  -28.402 -44.867 1.00 73.76  ? 296 LYS B CG    1 
ATOM   4368 C  CD    . LYS B 1 287 ? 13.245  -29.069 -44.251 1.00 77.53  ? 296 LYS B CD    1 
ATOM   4369 C  CE    . LYS B 1 287 ? 14.533  -28.306 -44.456 1.00 78.18  ? 296 LYS B CE    1 
ATOM   4370 N  NZ    . LYS B 1 287 ? 15.634  -28.905 -43.664 1.00 79.46  ? 296 LYS B NZ    1 
ATOM   4371 N  N     . LEU B 1 288 ? 8.064   -30.184 -46.530 1.00 80.15  ? 297 LEU B N     1 
ATOM   4372 C  CA    . LEU B 1 288 ? 6.974   -31.174 -46.699 1.00 87.36  ? 297 LEU B CA    1 
ATOM   4373 C  C     . LEU B 1 288 ? 7.443   -32.307 -47.622 1.00 95.09  ? 297 LEU B C     1 
ATOM   4374 O  O     . LEU B 1 288 ? 7.640   -32.038 -48.824 1.00 103.92 ? 297 LEU B O     1 
ATOM   4375 C  CB    . LEU B 1 288 ? 5.744   -30.433 -47.239 1.00 93.82  ? 297 LEU B CB    1 
ATOM   4376 C  CG    . LEU B 1 288 ? 5.279   -29.230 -46.409 1.00 92.32  ? 297 LEU B CG    1 
ATOM   4377 C  CD1   . LEU B 1 288 ? 4.228   -28.426 -47.155 1.00 94.21  ? 297 LEU B CD1   1 
ATOM   4378 C  CD2   . LEU B 1 288 ? 4.749   -29.657 -45.046 1.00 86.89  ? 297 LEU B CD2   1 
ATOM   4379 N  N     . GLU B 1 289 ? 7.608   -33.519 -47.067 1.00 104.23 ? 298 GLU B N     1 
ATOM   4380 C  CA    . GLU B 1 289 ? 7.827   -34.796 -47.814 1.00 103.60 ? 298 GLU B CA    1 
ATOM   4381 C  C     . GLU B 1 289 ? 9.173   -34.728 -48.548 1.00 106.18 ? 298 GLU B C     1 
ATOM   4382 O  O     . GLU B 1 289 ? 10.149  -34.231 -47.980 1.00 108.86 ? 298 GLU B O     1 
ATOM   4383 C  CB    . GLU B 1 289 ? 6.670   -35.068 -48.785 1.00 94.45  ? 298 GLU B CB    1 
ATOM   4384 C  CG    . GLU B 1 289 ? 6.912   -36.241 -49.721 1.00 92.21  ? 298 GLU B CG    1 
ATOM   4385 C  CD    . GLU B 1 289 ? 5.724   -36.614 -50.593 1.00 91.43  ? 298 GLU B CD    1 
ATOM   4386 O  OE1   . GLU B 1 289 ? 5.827   -36.450 -51.825 1.00 97.07  ? 298 GLU B OE1   1 
ATOM   4387 O  OE2   . GLU B 1 289 ? 4.700   -37.078 -50.048 1.00 82.39  ? 298 GLU B OE2   1 
HETATM 4388 ZN ZN    . ZN  C 2 .   ? -3.886  -27.545 -1.943  1.00 93.03  ? 401 ZN  A ZN    1 
HETATM 4389 N  N1    . AR6 D 3 .   ? -29.910 -9.646  -24.935 1.00 71.43  ? 402 AR6 A N1    1 
HETATM 4390 C  C2    . AR6 D 3 .   ? -30.613 -9.496  -23.804 1.00 71.89  ? 402 AR6 A C2    1 
HETATM 4391 N  N3    . AR6 D 3 .   ? -31.180 -10.419 -23.036 1.00 64.46  ? 402 AR6 A N3    1 
HETATM 4392 C  C4    . AR6 D 3 .   ? -30.957 -11.640 -23.543 1.00 63.16  ? 402 AR6 A C4    1 
HETATM 4393 C  C5    . AR6 D 3 .   ? -30.261 -11.957 -24.684 1.00 61.63  ? 402 AR6 A C5    1 
HETATM 4394 C  C6    . AR6 D 3 .   ? -29.708 -10.893 -25.414 1.00 64.88  ? 402 AR6 A C6    1 
HETATM 4395 N  N6    . AR6 D 3 .   ? -29.000 -11.052 -26.530 1.00 68.05  ? 402 AR6 A N6    1 
HETATM 4396 N  N7    . AR6 D 3 .   ? -30.264 -13.328 -24.882 1.00 65.15  ? 402 AR6 A N7    1 
HETATM 4397 C  C8    . AR6 D 3 .   ? -30.944 -13.807 -23.869 1.00 62.89  ? 402 AR6 A C8    1 
HETATM 4398 N  N9    . AR6 D 3 .   ? -31.408 -12.823 -23.036 1.00 58.48  ? 402 AR6 A N9    1 
HETATM 4399 P  PA    . AR6 D 3 .   ? -31.911 -17.312 -17.791 1.00 68.96  ? 402 AR6 A PA    1 
HETATM 4400 P  PB    . AR6 D 3 .   ? -29.961 -16.715 -15.664 1.00 66.50  ? 402 AR6 A PB    1 
HETATM 4401 C  "C1'" . AR6 D 3 .   ? -32.207 -12.952 -21.827 1.00 58.89  ? 402 AR6 A "C1'" 1 
HETATM 4402 O  O1A   . AR6 D 3 .   ? -31.703 -18.160 -19.001 1.00 70.80  ? 402 AR6 A O1A   1 
HETATM 4403 O  O1B   . AR6 D 3 .   ? -30.929 -15.733 -15.083 1.00 61.10  ? 402 AR6 A O1B   1 
HETATM 4404 C  C1D   . AR6 D 3 .   ? -29.925 -21.907 -13.869 1.00 76.33  ? 402 AR6 A C1D   1 
HETATM 4405 O  O1D   . AR6 D 3 .   ? -30.576 -22.747 -12.976 1.00 73.56  ? 402 AR6 A O1D   1 
HETATM 4406 C  "C2'" . AR6 D 3 .   ? -33.392 -13.916 -21.903 1.00 54.24  ? 402 AR6 A "C2'" 1 
HETATM 4407 O  "O2'" . AR6 D 3 .   ? -34.520 -13.157 -22.258 1.00 48.07  ? 402 AR6 A "O2'" 1 
HETATM 4408 O  O2A   . AR6 D 3 .   ? -32.895 -17.718 -16.742 1.00 65.82  ? 402 AR6 A O2A   1 
HETATM 4409 O  O2B   . AR6 D 3 .   ? -28.521 -16.354 -15.773 1.00 67.78  ? 402 AR6 A O2B   1 
HETATM 4410 C  C2D   . AR6 D 3 .   ? -28.389 -21.833 -13.711 1.00 81.40  ? 402 AR6 A C2D   1 
HETATM 4411 O  O2D   . AR6 D 3 .   ? -27.849 -22.198 -12.449 1.00 69.06  ? 402 AR6 A O2D   1 
HETATM 4412 C  "C3'" . AR6 D 3 .   ? -33.511 -14.450 -20.471 1.00 59.85  ? 402 AR6 A "C3'" 1 
HETATM 4413 O  "O3'" . AR6 D 3 .   ? -34.572 -13.866 -19.723 1.00 54.19  ? 402 AR6 A "O3'" 1 
HETATM 4414 O  O3A   . AR6 D 3 .   ? -30.468 -17.085 -17.129 1.00 68.90  ? 402 AR6 A O3A   1 
HETATM 4415 C  C3D   . AR6 D 3 .   ? -28.111 -20.367 -14.042 1.00 72.60  ? 402 AR6 A C3D   1 
HETATM 4416 O  O3D   . AR6 D 3 .   ? -26.868 -19.843 -13.585 1.00 68.19  ? 402 AR6 A O3D   1 
HETATM 4417 C  "C4'" . AR6 D 3 .   ? -32.181 -14.061 -19.802 1.00 61.01  ? 402 AR6 A "C4'" 1 
HETATM 4418 O  "O4'" . AR6 D 3 .   ? -31.369 -13.445 -20.820 1.00 62.40  ? 402 AR6 A "O4'" 1 
HETATM 4419 C  C4D   . AR6 D 3 .   ? -29.298 -19.738 -13.308 1.00 67.41  ? 402 AR6 A C4D   1 
HETATM 4420 O  O4D   . AR6 D 3 .   ? -30.402 -20.569 -13.701 1.00 69.29  ? 402 AR6 A O4D   1 
HETATM 4421 C  "C5'" . AR6 D 3 .   ? -31.405 -15.201 -19.212 1.00 63.01  ? 402 AR6 A "C5'" 1 
HETATM 4422 O  "O5'" . AR6 D 3 .   ? -32.259 -15.833 -18.250 1.00 63.48  ? 402 AR6 A "O5'" 1 
HETATM 4423 C  C5D   . AR6 D 3 .   ? -29.603 -18.288 -13.598 1.00 69.55  ? 402 AR6 A C5D   1 
HETATM 4424 O  O5D   . AR6 D 3 .   ? -30.103 -18.149 -14.955 1.00 72.21  ? 402 AR6 A O5D   1 
HETATM 4425 O  O1    . KDH E 4 .   ? -23.901 -31.434 -19.775 1.00 115.86 ? 403 KDH A O1    1 
HETATM 4426 C  C3    . KDH E 4 .   ? -23.430 -30.403 -19.003 1.00 131.02 ? 403 KDH A C3    1 
HETATM 4427 C  C6    . KDH E 4 .   ? -22.850 -30.676 -17.767 1.00 131.14 ? 403 KDH A C6    1 
HETATM 4428 O  O7    . KDH E 4 .   ? -22.751 -31.958 -17.312 1.00 139.88 ? 403 KDH A O7    1 
HETATM 4429 C  C9    . KDH E 4 .   ? -22.373 -29.630 -16.987 1.00 125.43 ? 403 KDH A C9    1 
HETATM 4430 O  O10   . KDH E 4 .   ? -21.791 -29.868 -15.768 1.00 97.74  ? 403 KDH A O10   1 
HETATM 4431 C  C12   . KDH E 4 .   ? -22.462 -28.334 -17.441 1.00 130.18 ? 403 KDH A C12   1 
HETATM 4432 C  C14   . KDH E 4 .   ? -23.038 -28.053 -18.681 1.00 131.82 ? 403 KDH A C14   1 
HETATM 4433 C  C15   . KDH E 4 .   ? -23.153 -26.631 -19.136 1.00 123.88 ? 403 KDH A C15   1 
HETATM 4434 C  C20   . KDH E 4 .   ? -24.706 -25.095 -20.054 1.00 119.84 ? 403 KDH A C20   1 
HETATM 4435 C  C21   . KDH E 4 .   ? -25.602 -24.854 -21.088 1.00 111.22 ? 403 KDH A C21   1 
HETATM 4436 C  C24   . KDH E 4 .   ? -25.897 -23.542 -21.427 1.00 113.93 ? 403 KDH A C24   1 
HETATM 4437 C  C26   . KDH E 4 .   ? -25.317 -22.473 -20.762 1.00 116.85 ? 403 KDH A C26   1 
HETATM 4438 C  C29   . KDH E 4 .   ? -24.418 -22.721 -19.741 1.00 127.37 ? 403 KDH A C29   1 
HETATM 4439 C  C31   . KDH E 4 .   ? -24.107 -24.038 -19.370 1.00 125.68 ? 403 KDH A C31   1 
HETATM 4440 C  C33   . KDH E 4 .   ? -23.034 -25.755 -17.904 1.00 128.75 ? 403 KDH A C33   1 
HETATM 4441 C  C36   . KDH E 4 .   ? -24.104 -25.728 -15.760 1.00 142.97 ? 403 KDH A C36   1 
HETATM 4442 C  C38   . KDH E 4 .   ? -25.249 -26.248 -14.984 1.00 144.58 ? 403 KDH A C38   1 
HETATM 4443 C  C39   . KDH E 4 .   ? -26.028 -27.261 -15.531 1.00 148.52 ? 403 KDH A C39   1 
HETATM 4444 C  C41   . KDH E 4 .   ? -25.518 -25.738 -13.715 1.00 144.64 ? 403 KDH A C41   1 
HETATM 4445 C  C01   . KDH E 4 .   ? -23.139 -24.288 -18.253 1.00 126.57 ? 403 KDH A C01   1 
HETATM 4446 O  O01   . KDH E 4 .   ? -24.431 -26.417 -19.763 1.00 117.89 ? 403 KDH A O01   1 
HETATM 4447 O  O02   . KDH E 4 .   ? -26.773 -23.288 -22.436 1.00 131.79 ? 403 KDH A O02   1 
HETATM 4448 O  O03   . KDH E 4 .   ? -23.824 -21.686 -19.072 1.00 116.35 ? 403 KDH A O03   1 
HETATM 4449 C  C4    . KDH E 4 .   ? -23.531 -29.099 -19.456 1.00 132.31 ? 403 KDH A C4    1 
HETATM 4450 O  O35   . KDH E 4 .   ? -24.154 -26.109 -17.046 1.00 136.46 ? 403 KDH A O35   1 
HETATM 4451 O  O37   . KDH E 4 .   ? -23.218 -25.077 -15.277 1.00 154.75 ? 403 KDH A O37   1 
HETATM 4452 C  C43   . KDH E 4 .   ? -26.580 -26.244 -12.993 1.00 145.54 ? 403 KDH A C43   1 
HETATM 4453 O  O44   . KDH E 4 .   ? -26.910 -25.799 -11.741 1.00 131.22 ? 403 KDH A O44   1 
HETATM 4454 C  C46   . KDH E 4 .   ? -27.366 -27.259 -13.534 1.00 153.96 ? 403 KDH A C46   1 
HETATM 4455 O  O47   . KDH E 4 .   ? -28.403 -27.727 -12.783 1.00 168.71 ? 403 KDH A O47   1 
HETATM 4456 C  C49   . KDH E 4 .   ? -27.081 -27.761 -14.808 1.00 157.79 ? 403 KDH A C49   1 
HETATM 4457 O  O50   . KDH E 4 .   ? -27.843 -28.754 -15.360 1.00 158.54 ? 403 KDH A O50   1 
HETATM 4458 ZN ZN    . ZN  F 2 .   ? -27.358 5.439   -60.548 1.00 88.62  ? 401 ZN  B ZN    1 
HETATM 4459 N  N1    . AR6 G 3 .   ? -19.270 -24.925 -37.697 1.00 76.27  ? 402 AR6 B N1    1 
HETATM 4460 C  C2    . AR6 G 3 .   ? -19.452 -25.715 -38.761 1.00 73.00  ? 402 AR6 B C2    1 
HETATM 4461 N  N3    . AR6 G 3 .   ? -20.561 -25.952 -39.455 1.00 66.31  ? 402 AR6 B N3    1 
HETATM 4462 C  C4    . AR6 G 3 .   ? -21.581 -25.243 -38.951 1.00 69.02  ? 402 AR6 B C4    1 
HETATM 4463 C  C5    . AR6 G 3 .   ? -21.561 -24.395 -37.867 1.00 74.05  ? 402 AR6 B C5    1 
HETATM 4464 C  C6    . AR6 G 3 .   ? -20.328 -24.229 -37.208 1.00 74.47  ? 402 AR6 B C6    1 
HETATM 4465 N  N6    . AR6 G 3 .   ? -20.160 -23.449 -36.142 1.00 67.37  ? 402 AR6 B N6    1 
HETATM 4466 N  N7    . AR6 G 3 .   ? -22.831 -23.875 -37.637 1.00 68.47  ? 402 AR6 B N7    1 
HETATM 4467 C  C8    . AR6 G 3 .   ? -23.576 -24.391 -38.583 1.00 73.84  ? 402 AR6 B C8    1 
HETATM 4468 N  N9    . AR6 G 3 .   ? -22.869 -25.246 -39.393 1.00 76.03  ? 402 AR6 B N9    1 
HETATM 4469 P  PA    . AR6 G 3 .   ? -27.210 -24.050 -44.624 1.00 76.36  ? 402 AR6 B PA    1 
HETATM 4470 P  PB    . AR6 G 3 .   ? -26.075 -22.392 -46.704 1.00 68.12  ? 402 AR6 B PB    1 
HETATM 4471 C  "C1'" . AR6 G 3 .   ? -23.327 -25.969 -40.558 1.00 75.06  ? 402 AR6 B "C1'" 1 
HETATM 4472 O  O1A   . AR6 G 3 .   ? -27.874 -24.844 -45.699 1.00 77.02  ? 402 AR6 B O1A   1 
HETATM 4473 O  O1B   . AR6 G 3 .   ? -25.444 -23.687 -47.113 1.00 68.55  ? 402 AR6 B O1B   1 
HETATM 4474 C  C1D   . AR6 G 3 .   ? -30.583 -20.407 -48.060 1.00 79.37  ? 402 AR6 B C1D   1 
HETATM 4475 O  O1D   . AR6 G 3 .   ? -31.872 -20.494 -48.523 1.00 81.74  ? 402 AR6 B O1D   1 
HETATM 4476 C  "C2'" . AR6 G 3 .   ? -24.651 -26.720 -40.465 1.00 65.46  ? 402 AR6 B "C2'" 1 
HETATM 4477 O  "O2'" . AR6 G 3 .   ? -24.335 -28.021 -40.015 1.00 61.03  ? 402 AR6 B "O2'" 1 
HETATM 4478 O  O2A   . AR6 G 3 .   ? -27.936 -23.744 -43.346 1.00 72.62  ? 402 AR6 B O2A   1 
HETATM 4479 O  O2B   . AR6 G 3 .   ? -25.260 -21.141 -46.659 1.00 68.11  ? 402 AR6 B O2B   1 
HETATM 4480 C  C2D   . AR6 G 3 .   ? -30.047 -18.992 -48.281 1.00 74.48  ? 402 AR6 B C2D   1 
HETATM 4481 O  O2D   . AR6 G 3 .   ? -30.449 -18.423 -49.506 1.00 67.72  ? 402 AR6 B O2D   1 
HETATM 4482 C  "C3'" . AR6 G 3 .   ? -25.189 -26.645 -41.910 1.00 72.88  ? 402 AR6 B "C3'" 1 
HETATM 4483 O  "O3'" . AR6 G 3 .   ? -25.048 -27.826 -42.701 1.00 61.92  ? 402 AR6 B "O3'" 1 
HETATM 4484 O  O3A   . AR6 G 3 .   ? -26.707 -22.665 -45.262 1.00 73.15  ? 402 AR6 B O3A   1 
HETATM 4485 C  C3D   . AR6 G 3 .   ? -28.548 -19.249 -48.261 1.00 73.89  ? 402 AR6 B C3D   1 
HETATM 4486 O  O3D   . AR6 G 3 .   ? -27.827 -18.175 -48.854 1.00 69.91  ? 402 AR6 B O3D   1 
HETATM 4487 C  "C4'" . AR6 G 3 .   ? -24.375 -25.519 -42.571 1.00 65.09  ? 402 AR6 B "C4'" 1 
HETATM 4488 O  "O4'" . AR6 G 3 .   ? -23.505 -24.997 -41.550 1.00 72.92  ? 402 AR6 B "O4'" 1 
HETATM 4489 C  C4D   . AR6 G 3 .   ? -28.477 -20.541 -49.088 1.00 74.90  ? 402 AR6 B C4D   1 
HETATM 4490 O  O4D   . AR6 G 3 .   ? -29.710 -21.251 -48.822 1.00 81.31  ? 402 AR6 B O4D   1 
HETATM 4491 C  "C5'" . AR6 G 3 .   ? -25.149 -24.348 -43.093 1.00 65.07  ? 402 AR6 B "C5'" 1 
HETATM 4492 O  "O5'" . AR6 G 3 .   ? -25.818 -24.753 -44.290 1.00 75.56  ? 402 AR6 B "O5'" 1 
HETATM 4493 C  C5D   . AR6 G 3 .   ? -27.300 -21.458 -48.841 1.00 76.47  ? 402 AR6 B C5D   1 
HETATM 4494 O  O5D   . AR6 G 3 .   ? -27.409 -22.102 -47.549 1.00 70.20  ? 402 AR6 B O5D   1 
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