data_8ZVB
# 
_entry.id   8ZVB 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZVB         pdb_00008zvb 10.2210/pdb8zvb/pdb 
WWPDB D_1300041317 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-09 ? 
2 'Structure model' 1 1 2025-04-16 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZVB 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-11 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              qiang_chen@scu.edu.cn 
_pdbx_contact_author.name_first         chen 
_pdbx_contact_author.name_last          Qiang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2398-4482 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Yu, Y.'   1 ? 
'Chen, Q.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            16 
_citation.language                  ? 
_citation.page_first                3141 
_citation.page_last                 3141 
_citation.title                     'A toxin-antitoxin system provides phage defense via DNA damage and repair.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-025-58540-9 
_citation.pdbx_database_id_PubMed   40169592 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Pu, H.'   1 ? 
primary 'Chen, Y.' 2 ? 
primary 'Zhao, X.' 3 ? 
primary 'Dai, L.'  4 ? 
primary 'Tong, A.' 5 ? 
primary 'Tang, D.' 6 ? 
primary 'Chen, Q.' 7 ? 
primary 'Yu, Y.'   8 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man ShosT          49096.617 1   ? ? ? ? 
2 non-polymer syn GLYCEROL       92.094    1   ? ? ? ? 
3 non-polymer syn 'CHLORIDE ION' 35.453    1   ? ? ? ? 
4 water       nat water          18.015    147 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GASGSMNNMYLKAVIFSIADVVLPLTSNTQPQELKSRIDSELRKLFAFLSSKGIKVIFLTNKNRNVRTHDGIVTLDEYLK
RKFPESIHFCRELDNNIPAKQTGKAIDFIMAALELKRNEMIYVGRSQEDLQAATNGNTLFINATWYEPVTEYGFQFSEPK
EIARFIDVFCLREQLWGWQGHFNEDVHYYALAPFSTYVPEFTMYSANARDLAKLSVGSPDFWIRYLGASIYFSGLSEGAS
FITTYVGHNAEDPYKLANIMEHDLKGLAVSFKGKYLKDLFLRHTTAIKSQQARIAKQEVNITSQINTVNLNPAPIKNLIT
GERYTNPPKLKGKKILVIDDFCTEGNAHETARMYLKAAGANVINISWLKTINRDVSICEPTRKIRPWEANTLDVDDINYV
GTIGYAENVTHGSAPQVLSEKIQQYDNWDWPQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GASGSMNNMYLKAVIFSIADVVLPLTSNTQPQELKSRIDSELRKLFAFLSSKGIKVIFLTNKNRNVRTHDGIVTLDEYLK
RKFPESIHFCRELDNNIPAKQTGKAIDFIMAALELKRNEMIYVGRSQEDLQAATNGNTLFINATWYEPVTEYGFQFSEPK
EIARFIDVFCLREQLWGWQGHFNEDVHYYALAPFSTYVPEFTMYSANARDLAKLSVGSPDFWIRYLGASIYFSGLSEGAS
FITTYVGHNAEDPYKLANIMEHDLKGLAVSFKGKYLKDLFLRHTTAIKSQQARIAKQEVNITSQINTVNLNPAPIKNLIT
GERYTNPPKLKGKKILVIDDFCTEGNAHETARMYLKAAGANVINISWLKTINRDVSICEPTRKIRPWEANTLDVDDINYV
GTIGYAENVTHGSAPQVLSEKIQQYDNWDWPQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 GLYCEROL       GOL 
3 'CHLORIDE ION' CL  
4 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   ALA n 
1 3   SER n 
1 4   GLY n 
1 5   SER n 
1 6   MET n 
1 7   ASN n 
1 8   ASN n 
1 9   MET n 
1 10  TYR n 
1 11  LEU n 
1 12  LYS n 
1 13  ALA n 
1 14  VAL n 
1 15  ILE n 
1 16  PHE n 
1 17  SER n 
1 18  ILE n 
1 19  ALA n 
1 20  ASP n 
1 21  VAL n 
1 22  VAL n 
1 23  LEU n 
1 24  PRO n 
1 25  LEU n 
1 26  THR n 
1 27  SER n 
1 28  ASN n 
1 29  THR n 
1 30  GLN n 
1 31  PRO n 
1 32  GLN n 
1 33  GLU n 
1 34  LEU n 
1 35  LYS n 
1 36  SER n 
1 37  ARG n 
1 38  ILE n 
1 39  ASP n 
1 40  SER n 
1 41  GLU n 
1 42  LEU n 
1 43  ARG n 
1 44  LYS n 
1 45  LEU n 
1 46  PHE n 
1 47  ALA n 
1 48  PHE n 
1 49  LEU n 
1 50  SER n 
1 51  SER n 
1 52  LYS n 
1 53  GLY n 
1 54  ILE n 
1 55  LYS n 
1 56  VAL n 
1 57  ILE n 
1 58  PHE n 
1 59  LEU n 
1 60  THR n 
1 61  ASN n 
1 62  LYS n 
1 63  ASN n 
1 64  ARG n 
1 65  ASN n 
1 66  VAL n 
1 67  ARG n 
1 68  THR n 
1 69  HIS n 
1 70  ASP n 
1 71  GLY n 
1 72  ILE n 
1 73  VAL n 
1 74  THR n 
1 75  LEU n 
1 76  ASP n 
1 77  GLU n 
1 78  TYR n 
1 79  LEU n 
1 80  LYS n 
1 81  ARG n 
1 82  LYS n 
1 83  PHE n 
1 84  PRO n 
1 85  GLU n 
1 86  SER n 
1 87  ILE n 
1 88  HIS n 
1 89  PHE n 
1 90  CYS n 
1 91  ARG n 
1 92  GLU n 
1 93  LEU n 
1 94  ASP n 
1 95  ASN n 
1 96  ASN n 
1 97  ILE n 
1 98  PRO n 
1 99  ALA n 
1 100 LYS n 
1 101 GLN n 
1 102 THR n 
1 103 GLY n 
1 104 LYS n 
1 105 ALA n 
1 106 ILE n 
1 107 ASP n 
1 108 PHE n 
1 109 ILE n 
1 110 MET n 
1 111 ALA n 
1 112 ALA n 
1 113 LEU n 
1 114 GLU n 
1 115 LEU n 
1 116 LYS n 
1 117 ARG n 
1 118 ASN n 
1 119 GLU n 
1 120 MET n 
1 121 ILE n 
1 122 TYR n 
1 123 VAL n 
1 124 GLY n 
1 125 ARG n 
1 126 SER n 
1 127 GLN n 
1 128 GLU n 
1 129 ASP n 
1 130 LEU n 
1 131 GLN n 
1 132 ALA n 
1 133 ALA n 
1 134 THR n 
1 135 ASN n 
1 136 GLY n 
1 137 ASN n 
1 138 THR n 
1 139 LEU n 
1 140 PHE n 
1 141 ILE n 
1 142 ASN n 
1 143 ALA n 
1 144 THR n 
1 145 TRP n 
1 146 TYR n 
1 147 GLU n 
1 148 PRO n 
1 149 VAL n 
1 150 THR n 
1 151 GLU n 
1 152 TYR n 
1 153 GLY n 
1 154 PHE n 
1 155 GLN n 
1 156 PHE n 
1 157 SER n 
1 158 GLU n 
1 159 PRO n 
1 160 LYS n 
1 161 GLU n 
1 162 ILE n 
1 163 ALA n 
1 164 ARG n 
1 165 PHE n 
1 166 ILE n 
1 167 ASP n 
1 168 VAL n 
1 169 PHE n 
1 170 CYS n 
1 171 LEU n 
1 172 ARG n 
1 173 GLU n 
1 174 GLN n 
1 175 LEU n 
1 176 TRP n 
1 177 GLY n 
1 178 TRP n 
1 179 GLN n 
1 180 GLY n 
1 181 HIS n 
1 182 PHE n 
1 183 ASN n 
1 184 GLU n 
1 185 ASP n 
1 186 VAL n 
1 187 HIS n 
1 188 TYR n 
1 189 TYR n 
1 190 ALA n 
1 191 LEU n 
1 192 ALA n 
1 193 PRO n 
1 194 PHE n 
1 195 SER n 
1 196 THR n 
1 197 TYR n 
1 198 VAL n 
1 199 PRO n 
1 200 GLU n 
1 201 PHE n 
1 202 THR n 
1 203 MET n 
1 204 TYR n 
1 205 SER n 
1 206 ALA n 
1 207 ASN n 
1 208 ALA n 
1 209 ARG n 
1 210 ASP n 
1 211 LEU n 
1 212 ALA n 
1 213 LYS n 
1 214 LEU n 
1 215 SER n 
1 216 VAL n 
1 217 GLY n 
1 218 SER n 
1 219 PRO n 
1 220 ASP n 
1 221 PHE n 
1 222 TRP n 
1 223 ILE n 
1 224 ARG n 
1 225 TYR n 
1 226 LEU n 
1 227 GLY n 
1 228 ALA n 
1 229 SER n 
1 230 ILE n 
1 231 TYR n 
1 232 PHE n 
1 233 SER n 
1 234 GLY n 
1 235 LEU n 
1 236 SER n 
1 237 GLU n 
1 238 GLY n 
1 239 ALA n 
1 240 SER n 
1 241 PHE n 
1 242 ILE n 
1 243 THR n 
1 244 THR n 
1 245 TYR n 
1 246 VAL n 
1 247 GLY n 
1 248 HIS n 
1 249 ASN n 
1 250 ALA n 
1 251 GLU n 
1 252 ASP n 
1 253 PRO n 
1 254 TYR n 
1 255 LYS n 
1 256 LEU n 
1 257 ALA n 
1 258 ASN n 
1 259 ILE n 
1 260 MET n 
1 261 GLU n 
1 262 HIS n 
1 263 ASP n 
1 264 LEU n 
1 265 LYS n 
1 266 GLY n 
1 267 LEU n 
1 268 ALA n 
1 269 VAL n 
1 270 SER n 
1 271 PHE n 
1 272 LYS n 
1 273 GLY n 
1 274 LYS n 
1 275 TYR n 
1 276 LEU n 
1 277 LYS n 
1 278 ASP n 
1 279 LEU n 
1 280 PHE n 
1 281 LEU n 
1 282 ARG n 
1 283 HIS n 
1 284 THR n 
1 285 THR n 
1 286 ALA n 
1 287 ILE n 
1 288 LYS n 
1 289 SER n 
1 290 GLN n 
1 291 GLN n 
1 292 ALA n 
1 293 ARG n 
1 294 ILE n 
1 295 ALA n 
1 296 LYS n 
1 297 GLN n 
1 298 GLU n 
1 299 VAL n 
1 300 ASN n 
1 301 ILE n 
1 302 THR n 
1 303 SER n 
1 304 GLN n 
1 305 ILE n 
1 306 ASN n 
1 307 THR n 
1 308 VAL n 
1 309 ASN n 
1 310 LEU n 
1 311 ASN n 
1 312 PRO n 
1 313 ALA n 
1 314 PRO n 
1 315 ILE n 
1 316 LYS n 
1 317 ASN n 
1 318 LEU n 
1 319 ILE n 
1 320 THR n 
1 321 GLY n 
1 322 GLU n 
1 323 ARG n 
1 324 TYR n 
1 325 THR n 
1 326 ASN n 
1 327 PRO n 
1 328 PRO n 
1 329 LYS n 
1 330 LEU n 
1 331 LYS n 
1 332 GLY n 
1 333 LYS n 
1 334 LYS n 
1 335 ILE n 
1 336 LEU n 
1 337 VAL n 
1 338 ILE n 
1 339 ASP n 
1 340 ASP n 
1 341 PHE n 
1 342 CYS n 
1 343 THR n 
1 344 GLU n 
1 345 GLY n 
1 346 ASN n 
1 347 ALA n 
1 348 HIS n 
1 349 GLU n 
1 350 THR n 
1 351 ALA n 
1 352 ARG n 
1 353 MET n 
1 354 TYR n 
1 355 LEU n 
1 356 LYS n 
1 357 ALA n 
1 358 ALA n 
1 359 GLY n 
1 360 ALA n 
1 361 ASN n 
1 362 VAL n 
1 363 ILE n 
1 364 ASN n 
1 365 ILE n 
1 366 SER n 
1 367 TRP n 
1 368 LEU n 
1 369 LYS n 
1 370 THR n 
1 371 ILE n 
1 372 ASN n 
1 373 ARG n 
1 374 ASP n 
1 375 VAL n 
1 376 SER n 
1 377 ILE n 
1 378 CYS n 
1 379 GLU n 
1 380 PRO n 
1 381 THR n 
1 382 ARG n 
1 383 LYS n 
1 384 ILE n 
1 385 ARG n 
1 386 PRO n 
1 387 TRP n 
1 388 GLU n 
1 389 ALA n 
1 390 ASN n 
1 391 THR n 
1 392 LEU n 
1 393 ASP n 
1 394 VAL n 
1 395 ASP n 
1 396 ASP n 
1 397 ILE n 
1 398 ASN n 
1 399 TYR n 
1 400 VAL n 
1 401 GLY n 
1 402 THR n 
1 403 ILE n 
1 404 GLY n 
1 405 TYR n 
1 406 ALA n 
1 407 GLU n 
1 408 ASN n 
1 409 VAL n 
1 410 THR n 
1 411 HIS n 
1 412 GLY n 
1 413 SER n 
1 414 ALA n 
1 415 PRO n 
1 416 GLN n 
1 417 VAL n 
1 418 LEU n 
1 419 SER n 
1 420 GLU n 
1 421 LYS n 
1 422 ILE n 
1 423 GLN n 
1 424 GLN n 
1 425 TYR n 
1 426 ASP n 
1 427 ASN n 
1 428 TRP n 
1 429 ASP n 
1 430 TRP n 
1 431 PRO n 
1 432 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   432 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 APECO1_1183 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Escherichia coli O1:K1 / APEC' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     405955 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                               'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'  ?                               'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE        ?                               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL        'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE       ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -7  ?   ?   ?   A . n 
A 1 2   ALA 2   -6  ?   ?   ?   A . n 
A 1 3   SER 3   -5  ?   ?   ?   A . n 
A 1 4   GLY 4   -4  ?   ?   ?   A . n 
A 1 5   SER 5   -3  ?   ?   ?   A . n 
A 1 6   MET 6   -2  ?   ?   ?   A . n 
A 1 7   ASN 7   -1  ?   ?   ?   A . n 
A 1 8   ASN 8   0   ?   ?   ?   A . n 
A 1 9   MET 9   1   1   MET MET A . n 
A 1 10  TYR 10  2   2   TYR TYR A . n 
A 1 11  LEU 11  3   3   LEU LEU A . n 
A 1 12  LYS 12  4   4   LYS LYS A . n 
A 1 13  ALA 13  5   5   ALA ALA A . n 
A 1 14  VAL 14  6   6   VAL VAL A . n 
A 1 15  ILE 15  7   7   ILE ILE A . n 
A 1 16  PHE 16  8   8   PHE PHE A . n 
A 1 17  SER 17  9   9   SER SER A . n 
A 1 18  ILE 18  10  10  ILE ILE A . n 
A 1 19  ALA 19  11  11  ALA ALA A . n 
A 1 20  ASP 20  12  12  ASP ASP A . n 
A 1 21  VAL 21  13  13  VAL VAL A . n 
A 1 22  VAL 22  14  14  VAL VAL A . n 
A 1 23  LEU 23  15  15  LEU LEU A . n 
A 1 24  PRO 24  16  16  PRO PRO A . n 
A 1 25  LEU 25  17  17  LEU LEU A . n 
A 1 26  THR 26  18  18  THR THR A . n 
A 1 27  SER 27  19  19  SER SER A . n 
A 1 28  ASN 28  20  20  ASN ASN A . n 
A 1 29  THR 29  21  21  THR THR A . n 
A 1 30  GLN 30  22  22  GLN GLN A . n 
A 1 31  PRO 31  23  23  PRO PRO A . n 
A 1 32  GLN 32  24  24  GLN GLN A . n 
A 1 33  GLU 33  25  25  GLU GLU A . n 
A 1 34  LEU 34  26  26  LEU LEU A . n 
A 1 35  LYS 35  27  27  LYS LYS A . n 
A 1 36  SER 36  28  28  SER SER A . n 
A 1 37  ARG 37  29  29  ARG ARG A . n 
A 1 38  ILE 38  30  30  ILE ILE A . n 
A 1 39  ASP 39  31  31  ASP ASP A . n 
A 1 40  SER 40  32  32  SER SER A . n 
A 1 41  GLU 41  33  33  GLU GLU A . n 
A 1 42  LEU 42  34  34  LEU LEU A . n 
A 1 43  ARG 43  35  35  ARG ARG A . n 
A 1 44  LYS 44  36  36  LYS LYS A . n 
A 1 45  LEU 45  37  37  LEU LEU A . n 
A 1 46  PHE 46  38  38  PHE PHE A . n 
A 1 47  ALA 47  39  39  ALA ALA A . n 
A 1 48  PHE 48  40  40  PHE PHE A . n 
A 1 49  LEU 49  41  41  LEU LEU A . n 
A 1 50  SER 50  42  42  SER SER A . n 
A 1 51  SER 51  43  43  SER SER A . n 
A 1 52  LYS 52  44  44  LYS LYS A . n 
A 1 53  GLY 53  45  45  GLY GLY A . n 
A 1 54  ILE 54  46  46  ILE ILE A . n 
A 1 55  LYS 55  47  47  LYS LYS A . n 
A 1 56  VAL 56  48  48  VAL VAL A . n 
A 1 57  ILE 57  49  49  ILE ILE A . n 
A 1 58  PHE 58  50  50  PHE PHE A . n 
A 1 59  LEU 59  51  51  LEU LEU A . n 
A 1 60  THR 60  52  52  THR THR A . n 
A 1 61  ASN 61  53  53  ASN ASN A . n 
A 1 62  LYS 62  54  54  LYS LYS A . n 
A 1 63  ASN 63  55  55  ASN ASN A . n 
A 1 64  ARG 64  56  56  ARG ARG A . n 
A 1 65  ASN 65  57  57  ASN ASN A . n 
A 1 66  VAL 66  58  58  VAL VAL A . n 
A 1 67  ARG 67  59  59  ARG ARG A . n 
A 1 68  THR 68  60  60  THR THR A . n 
A 1 69  HIS 69  61  61  HIS HIS A . n 
A 1 70  ASP 70  62  62  ASP ASP A . n 
A 1 71  GLY 71  63  63  GLY GLY A . n 
A 1 72  ILE 72  64  64  ILE ILE A . n 
A 1 73  VAL 73  65  65  VAL VAL A . n 
A 1 74  THR 74  66  66  THR THR A . n 
A 1 75  LEU 75  67  67  LEU LEU A . n 
A 1 76  ASP 76  68  68  ASP ASP A . n 
A 1 77  GLU 77  69  69  GLU GLU A . n 
A 1 78  TYR 78  70  70  TYR TYR A . n 
A 1 79  LEU 79  71  71  LEU LEU A . n 
A 1 80  LYS 80  72  72  LYS LYS A . n 
A 1 81  ARG 81  73  73  ARG ARG A . n 
A 1 82  LYS 82  74  74  LYS LYS A . n 
A 1 83  PHE 83  75  75  PHE PHE A . n 
A 1 84  PRO 84  76  76  PRO PRO A . n 
A 1 85  GLU 85  77  77  GLU GLU A . n 
A 1 86  SER 86  78  78  SER SER A . n 
A 1 87  ILE 87  79  79  ILE ILE A . n 
A 1 88  HIS 88  80  80  HIS HIS A . n 
A 1 89  PHE 89  81  81  PHE PHE A . n 
A 1 90  CYS 90  82  82  CYS CYS A . n 
A 1 91  ARG 91  83  83  ARG ARG A . n 
A 1 92  GLU 92  84  84  GLU GLU A . n 
A 1 93  LEU 93  85  85  LEU LEU A . n 
A 1 94  ASP 94  86  86  ASP ASP A . n 
A 1 95  ASN 95  87  87  ASN ASN A . n 
A 1 96  ASN 96  88  88  ASN ASN A . n 
A 1 97  ILE 97  89  89  ILE ILE A . n 
A 1 98  PRO 98  90  90  PRO PRO A . n 
A 1 99  ALA 99  91  91  ALA ALA A . n 
A 1 100 LYS 100 92  92  LYS LYS A . n 
A 1 101 GLN 101 93  93  GLN GLN A . n 
A 1 102 THR 102 94  94  THR THR A . n 
A 1 103 GLY 103 95  95  GLY GLY A . n 
A 1 104 LYS 104 96  96  LYS LYS A . n 
A 1 105 ALA 105 97  97  ALA ALA A . n 
A 1 106 ILE 106 98  98  ILE ILE A . n 
A 1 107 ASP 107 99  99  ASP ASP A . n 
A 1 108 PHE 108 100 100 PHE PHE A . n 
A 1 109 ILE 109 101 101 ILE ILE A . n 
A 1 110 MET 110 102 102 MET MET A . n 
A 1 111 ALA 111 103 103 ALA ALA A . n 
A 1 112 ALA 112 104 104 ALA ALA A . n 
A 1 113 LEU 113 105 105 LEU LEU A . n 
A 1 114 GLU 114 106 106 GLU GLU A . n 
A 1 115 LEU 115 107 107 LEU LEU A . n 
A 1 116 LYS 116 108 108 LYS LYS A . n 
A 1 117 ARG 117 109 109 ARG ARG A . n 
A 1 118 ASN 118 110 110 ASN ASN A . n 
A 1 119 GLU 119 111 111 GLU GLU A . n 
A 1 120 MET 120 112 112 MET MET A . n 
A 1 121 ILE 121 113 113 ILE ILE A . n 
A 1 122 TYR 122 114 114 TYR TYR A . n 
A 1 123 VAL 123 115 115 VAL VAL A . n 
A 1 124 GLY 124 116 116 GLY GLY A . n 
A 1 125 ARG 125 117 117 ARG ARG A . n 
A 1 126 SER 126 118 118 SER SER A . n 
A 1 127 GLN 127 119 119 GLN GLN A . n 
A 1 128 GLU 128 120 120 GLU GLU A . n 
A 1 129 ASP 129 121 121 ASP ASP A . n 
A 1 130 LEU 130 122 122 LEU LEU A . n 
A 1 131 GLN 131 123 123 GLN GLN A . n 
A 1 132 ALA 132 124 124 ALA ALA A . n 
A 1 133 ALA 133 125 125 ALA ALA A . n 
A 1 134 THR 134 126 126 THR THR A . n 
A 1 135 ASN 135 127 127 ASN ASN A . n 
A 1 136 GLY 136 128 128 GLY GLY A . n 
A 1 137 ASN 137 129 129 ASN ASN A . n 
A 1 138 THR 138 130 130 THR THR A . n 
A 1 139 LEU 139 131 131 LEU LEU A . n 
A 1 140 PHE 140 132 132 PHE PHE A . n 
A 1 141 ILE 141 133 133 ILE ILE A . n 
A 1 142 ASN 142 134 134 ASN ASN A . n 
A 1 143 ALA 143 135 135 ALA ALA A . n 
A 1 144 THR 144 136 136 THR THR A . n 
A 1 145 TRP 145 137 137 TRP TRP A . n 
A 1 146 TYR 146 138 138 TYR TYR A . n 
A 1 147 GLU 147 139 139 GLU GLU A . n 
A 1 148 PRO 148 140 140 PRO PRO A . n 
A 1 149 VAL 149 141 141 VAL VAL A . n 
A 1 150 THR 150 142 142 THR THR A . n 
A 1 151 GLU 151 143 143 GLU GLU A . n 
A 1 152 TYR 152 144 144 TYR TYR A . n 
A 1 153 GLY 153 145 145 GLY GLY A . n 
A 1 154 PHE 154 146 146 PHE PHE A . n 
A 1 155 GLN 155 147 147 GLN GLN A . n 
A 1 156 PHE 156 148 148 PHE PHE A . n 
A 1 157 SER 157 149 149 SER SER A . n 
A 1 158 GLU 158 150 150 GLU GLU A . n 
A 1 159 PRO 159 151 151 PRO PRO A . n 
A 1 160 LYS 160 152 152 LYS LYS A . n 
A 1 161 GLU 161 153 153 GLU GLU A . n 
A 1 162 ILE 162 154 154 ILE ILE A . n 
A 1 163 ALA 163 155 155 ALA ALA A . n 
A 1 164 ARG 164 156 156 ARG ARG A . n 
A 1 165 PHE 165 157 157 PHE PHE A . n 
A 1 166 ILE 166 158 158 ILE ILE A . n 
A 1 167 ASP 167 159 159 ASP ASP A . n 
A 1 168 VAL 168 160 160 VAL VAL A . n 
A 1 169 PHE 169 161 161 PHE PHE A . n 
A 1 170 CYS 170 162 162 CYS CYS A . n 
A 1 171 LEU 171 163 163 LEU LEU A . n 
A 1 172 ARG 172 164 164 ARG ARG A . n 
A 1 173 GLU 173 165 165 GLU GLU A . n 
A 1 174 GLN 174 166 166 GLN GLN A . n 
A 1 175 LEU 175 167 167 LEU LEU A . n 
A 1 176 TRP 176 168 168 TRP TRP A . n 
A 1 177 GLY 177 169 169 GLY GLY A . n 
A 1 178 TRP 178 170 170 TRP TRP A . n 
A 1 179 GLN 179 171 171 GLN GLN A . n 
A 1 180 GLY 180 172 172 GLY GLY A . n 
A 1 181 HIS 181 173 173 HIS HIS A . n 
A 1 182 PHE 182 174 174 PHE PHE A . n 
A 1 183 ASN 183 175 175 ASN ASN A . n 
A 1 184 GLU 184 176 176 GLU GLU A . n 
A 1 185 ASP 185 177 177 ASP ASP A . n 
A 1 186 VAL 186 178 178 VAL VAL A . n 
A 1 187 HIS 187 179 179 HIS HIS A . n 
A 1 188 TYR 188 180 180 TYR TYR A . n 
A 1 189 TYR 189 181 181 TYR TYR A . n 
A 1 190 ALA 190 182 182 ALA ALA A . n 
A 1 191 LEU 191 183 183 LEU LEU A . n 
A 1 192 ALA 192 184 184 ALA ALA A . n 
A 1 193 PRO 193 185 185 PRO PRO A . n 
A 1 194 PHE 194 186 186 PHE PHE A . n 
A 1 195 SER 195 187 187 SER SER A . n 
A 1 196 THR 196 188 188 THR THR A . n 
A 1 197 TYR 197 189 189 TYR TYR A . n 
A 1 198 VAL 198 190 190 VAL VAL A . n 
A 1 199 PRO 199 191 191 PRO PRO A . n 
A 1 200 GLU 200 192 ?   ?   ?   A . n 
A 1 201 PHE 201 193 ?   ?   ?   A . n 
A 1 202 THR 202 194 ?   ?   ?   A . n 
A 1 203 MET 203 195 ?   ?   ?   A . n 
A 1 204 TYR 204 196 ?   ?   ?   A . n 
A 1 205 SER 205 197 ?   ?   ?   A . n 
A 1 206 ALA 206 198 ?   ?   ?   A . n 
A 1 207 ASN 207 199 ?   ?   ?   A . n 
A 1 208 ALA 208 200 ?   ?   ?   A . n 
A 1 209 ARG 209 201 ?   ?   ?   A . n 
A 1 210 ASP 210 202 ?   ?   ?   A . n 
A 1 211 LEU 211 203 ?   ?   ?   A . n 
A 1 212 ALA 212 204 ?   ?   ?   A . n 
A 1 213 LYS 213 205 ?   ?   ?   A . n 
A 1 214 LEU 214 206 206 LEU LEU A . n 
A 1 215 SER 215 207 207 SER SER A . n 
A 1 216 VAL 216 208 208 VAL VAL A . n 
A 1 217 GLY 217 209 209 GLY GLY A . n 
A 1 218 SER 218 210 210 SER SER A . n 
A 1 219 PRO 219 211 211 PRO PRO A . n 
A 1 220 ASP 220 212 212 ASP ASP A . n 
A 1 221 PHE 221 213 213 PHE PHE A . n 
A 1 222 TRP 222 214 214 TRP TRP A . n 
A 1 223 ILE 223 215 215 ILE ILE A . n 
A 1 224 ARG 224 216 216 ARG ARG A . n 
A 1 225 TYR 225 217 217 TYR TYR A . n 
A 1 226 LEU 226 218 218 LEU LEU A . n 
A 1 227 GLY 227 219 219 GLY GLY A . n 
A 1 228 ALA 228 220 220 ALA ALA A . n 
A 1 229 SER 229 221 221 SER SER A . n 
A 1 230 ILE 230 222 222 ILE ILE A . n 
A 1 231 TYR 231 223 223 TYR TYR A . n 
A 1 232 PHE 232 224 224 PHE PHE A . n 
A 1 233 SER 233 225 225 SER SER A . n 
A 1 234 GLY 234 226 226 GLY GLY A . n 
A 1 235 LEU 235 227 227 LEU LEU A . n 
A 1 236 SER 236 228 228 SER SER A . n 
A 1 237 GLU 237 229 229 GLU GLU A . n 
A 1 238 GLY 238 230 230 GLY GLY A . n 
A 1 239 ALA 239 231 231 ALA ALA A . n 
A 1 240 SER 240 232 232 SER SER A . n 
A 1 241 PHE 241 233 233 PHE PHE A . n 
A 1 242 ILE 242 234 234 ILE ILE A . n 
A 1 243 THR 243 235 235 THR THR A . n 
A 1 244 THR 244 236 236 THR THR A . n 
A 1 245 TYR 245 237 237 TYR TYR A . n 
A 1 246 VAL 246 238 238 VAL VAL A . n 
A 1 247 GLY 247 239 239 GLY GLY A . n 
A 1 248 HIS 248 240 240 HIS HIS A . n 
A 1 249 ASN 249 241 241 ASN ASN A . n 
A 1 250 ALA 250 242 242 ALA ALA A . n 
A 1 251 GLU 251 243 243 GLU GLU A . n 
A 1 252 ASP 252 244 244 ASP ASP A . n 
A 1 253 PRO 253 245 245 PRO PRO A . n 
A 1 254 TYR 254 246 246 TYR TYR A . n 
A 1 255 LYS 255 247 247 LYS LYS A . n 
A 1 256 LEU 256 248 248 LEU LEU A . n 
A 1 257 ALA 257 249 249 ALA ALA A . n 
A 1 258 ASN 258 250 250 ASN ASN A . n 
A 1 259 ILE 259 251 251 ILE ILE A . n 
A 1 260 MET 260 252 252 MET MET A . n 
A 1 261 GLU 261 253 253 GLU GLU A . n 
A 1 262 HIS 262 254 254 HIS HIS A . n 
A 1 263 ASP 263 255 255 ASP ASP A . n 
A 1 264 LEU 264 256 256 LEU LEU A . n 
A 1 265 LYS 265 257 257 LYS LYS A . n 
A 1 266 GLY 266 258 258 GLY GLY A . n 
A 1 267 LEU 267 259 259 LEU LEU A . n 
A 1 268 ALA 268 260 260 ALA ALA A . n 
A 1 269 VAL 269 261 261 VAL VAL A . n 
A 1 270 SER 270 262 262 SER SER A . n 
A 1 271 PHE 271 263 263 PHE PHE A . n 
A 1 272 LYS 272 264 264 LYS LYS A . n 
A 1 273 GLY 273 265 265 GLY GLY A . n 
A 1 274 LYS 274 266 266 LYS LYS A . n 
A 1 275 TYR 275 267 267 TYR TYR A . n 
A 1 276 LEU 276 268 268 LEU LEU A . n 
A 1 277 LYS 277 269 269 LYS LYS A . n 
A 1 278 ASP 278 270 270 ASP ASP A . n 
A 1 279 LEU 279 271 271 LEU LEU A . n 
A 1 280 PHE 280 272 272 PHE PHE A . n 
A 1 281 LEU 281 273 273 LEU LEU A . n 
A 1 282 ARG 282 274 274 ARG ARG A . n 
A 1 283 HIS 283 275 275 HIS HIS A . n 
A 1 284 THR 284 276 276 THR THR A . n 
A 1 285 THR 285 277 277 THR THR A . n 
A 1 286 ALA 286 278 278 ALA ALA A . n 
A 1 287 ILE 287 279 ?   ?   ?   A . n 
A 1 288 LYS 288 280 ?   ?   ?   A . n 
A 1 289 SER 289 281 ?   ?   ?   A . n 
A 1 290 GLN 290 282 ?   ?   ?   A . n 
A 1 291 GLN 291 283 ?   ?   ?   A . n 
A 1 292 ALA 292 284 ?   ?   ?   A . n 
A 1 293 ARG 293 285 ?   ?   ?   A . n 
A 1 294 ILE 294 286 ?   ?   ?   A . n 
A 1 295 ALA 295 287 ?   ?   ?   A . n 
A 1 296 LYS 296 288 ?   ?   ?   A . n 
A 1 297 GLN 297 289 ?   ?   ?   A . n 
A 1 298 GLU 298 290 ?   ?   ?   A . n 
A 1 299 VAL 299 291 291 VAL VAL A . n 
A 1 300 ASN 300 292 292 ASN ASN A . n 
A 1 301 ILE 301 293 293 ILE ILE A . n 
A 1 302 THR 302 294 294 THR THR A . n 
A 1 303 SER 303 295 295 SER SER A . n 
A 1 304 GLN 304 296 296 GLN GLN A . n 
A 1 305 ILE 305 297 297 ILE ILE A . n 
A 1 306 ASN 306 298 298 ASN ASN A . n 
A 1 307 THR 307 299 299 THR THR A . n 
A 1 308 VAL 308 300 300 VAL VAL A . n 
A 1 309 ASN 309 301 301 ASN ASN A . n 
A 1 310 LEU 310 302 302 LEU LEU A . n 
A 1 311 ASN 311 303 303 ASN ASN A . n 
A 1 312 PRO 312 304 304 PRO PRO A . n 
A 1 313 ALA 313 305 305 ALA ALA A . n 
A 1 314 PRO 314 306 306 PRO PRO A . n 
A 1 315 ILE 315 307 307 ILE ILE A . n 
A 1 316 LYS 316 308 308 LYS LYS A . n 
A 1 317 ASN 317 309 309 ASN ASN A . n 
A 1 318 LEU 318 310 310 LEU LEU A . n 
A 1 319 ILE 319 311 311 ILE ILE A . n 
A 1 320 THR 320 312 312 THR THR A . n 
A 1 321 GLY 321 313 313 GLY GLY A . n 
A 1 322 GLU 322 314 314 GLU GLU A . n 
A 1 323 ARG 323 315 315 ARG ARG A . n 
A 1 324 TYR 324 316 316 TYR TYR A . n 
A 1 325 THR 325 317 317 THR THR A . n 
A 1 326 ASN 326 318 318 ASN ASN A . n 
A 1 327 PRO 327 319 319 PRO PRO A . n 
A 1 328 PRO 328 320 320 PRO PRO A . n 
A 1 329 LYS 329 321 321 LYS LYS A . n 
A 1 330 LEU 330 322 322 LEU LEU A . n 
A 1 331 LYS 331 323 323 LYS LYS A . n 
A 1 332 GLY 332 324 324 GLY GLY A . n 
A 1 333 LYS 333 325 325 LYS LYS A . n 
A 1 334 LYS 334 326 326 LYS LYS A . n 
A 1 335 ILE 335 327 327 ILE ILE A . n 
A 1 336 LEU 336 328 328 LEU LEU A . n 
A 1 337 VAL 337 329 329 VAL VAL A . n 
A 1 338 ILE 338 330 330 ILE ILE A . n 
A 1 339 ASP 339 331 331 ASP ASP A . n 
A 1 340 ASP 340 332 332 ASP ASP A . n 
A 1 341 PHE 341 333 333 PHE PHE A . n 
A 1 342 CYS 342 334 334 CYS CYS A . n 
A 1 343 THR 343 335 335 THR THR A . n 
A 1 344 GLU 344 336 336 GLU GLU A . n 
A 1 345 GLY 345 337 337 GLY GLY A . n 
A 1 346 ASN 346 338 338 ASN ASN A . n 
A 1 347 ALA 347 339 339 ALA ALA A . n 
A 1 348 HIS 348 340 340 HIS HIS A . n 
A 1 349 GLU 349 341 341 GLU GLU A . n 
A 1 350 THR 350 342 342 THR THR A . n 
A 1 351 ALA 351 343 343 ALA ALA A . n 
A 1 352 ARG 352 344 344 ARG ARG A . n 
A 1 353 MET 353 345 345 MET MET A . n 
A 1 354 TYR 354 346 346 TYR TYR A . n 
A 1 355 LEU 355 347 347 LEU LEU A . n 
A 1 356 LYS 356 348 348 LYS LYS A . n 
A 1 357 ALA 357 349 349 ALA ALA A . n 
A 1 358 ALA 358 350 350 ALA ALA A . n 
A 1 359 GLY 359 351 351 GLY GLY A . n 
A 1 360 ALA 360 352 352 ALA ALA A . n 
A 1 361 ASN 361 353 353 ASN ASN A . n 
A 1 362 VAL 362 354 354 VAL VAL A . n 
A 1 363 ILE 363 355 355 ILE ILE A . n 
A 1 364 ASN 364 356 356 ASN ASN A . n 
A 1 365 ILE 365 357 357 ILE ILE A . n 
A 1 366 SER 366 358 358 SER SER A . n 
A 1 367 TRP 367 359 359 TRP TRP A . n 
A 1 368 LEU 368 360 360 LEU LEU A . n 
A 1 369 LYS 369 361 361 LYS LYS A . n 
A 1 370 THR 370 362 362 THR THR A . n 
A 1 371 ILE 371 363 363 ILE ILE A . n 
A 1 372 ASN 372 364 364 ASN ASN A . n 
A 1 373 ARG 373 365 365 ARG ARG A . n 
A 1 374 ASP 374 366 366 ASP ASP A . n 
A 1 375 VAL 375 367 367 VAL VAL A . n 
A 1 376 SER 376 368 368 SER SER A . n 
A 1 377 ILE 377 369 369 ILE ILE A . n 
A 1 378 CYS 378 370 370 CYS CYS A . n 
A 1 379 GLU 379 371 371 GLU GLU A . n 
A 1 380 PRO 380 372 372 PRO PRO A . n 
A 1 381 THR 381 373 373 THR THR A . n 
A 1 382 ARG 382 374 374 ARG ARG A . n 
A 1 383 LYS 383 375 375 LYS LYS A . n 
A 1 384 ILE 384 376 376 ILE ILE A . n 
A 1 385 ARG 385 377 377 ARG ARG A . n 
A 1 386 PRO 386 378 378 PRO PRO A . n 
A 1 387 TRP 387 379 379 TRP TRP A . n 
A 1 388 GLU 388 380 380 GLU GLU A . n 
A 1 389 ALA 389 381 381 ALA ALA A . n 
A 1 390 ASN 390 382 382 ASN ASN A . n 
A 1 391 THR 391 383 383 THR THR A . n 
A 1 392 LEU 392 384 384 LEU LEU A . n 
A 1 393 ASP 393 385 385 ASP ASP A . n 
A 1 394 VAL 394 386 386 VAL VAL A . n 
A 1 395 ASP 395 387 387 ASP ASP A . n 
A 1 396 ASP 396 388 388 ASP ASP A . n 
A 1 397 ILE 397 389 389 ILE ILE A . n 
A 1 398 ASN 398 390 390 ASN ASN A . n 
A 1 399 TYR 399 391 391 TYR TYR A . n 
A 1 400 VAL 400 392 392 VAL VAL A . n 
A 1 401 GLY 401 393 393 GLY GLY A . n 
A 1 402 THR 402 394 394 THR THR A . n 
A 1 403 ILE 403 395 395 ILE ILE A . n 
A 1 404 GLY 404 396 396 GLY GLY A . n 
A 1 405 TYR 405 397 397 TYR TYR A . n 
A 1 406 ALA 406 398 398 ALA ALA A . n 
A 1 407 GLU 407 399 399 GLU GLU A . n 
A 1 408 ASN 408 400 400 ASN ASN A . n 
A 1 409 VAL 409 401 401 VAL VAL A . n 
A 1 410 THR 410 402 402 THR THR A . n 
A 1 411 HIS 411 403 403 HIS HIS A . n 
A 1 412 GLY 412 404 ?   ?   ?   A . n 
A 1 413 SER 413 405 ?   ?   ?   A . n 
A 1 414 ALA 414 406 ?   ?   ?   A . n 
A 1 415 PRO 415 407 ?   ?   ?   A . n 
A 1 416 GLN 416 408 ?   ?   ?   A . n 
A 1 417 VAL 417 409 409 VAL VAL A . n 
A 1 418 LEU 418 410 410 LEU LEU A . n 
A 1 419 SER 419 411 411 SER SER A . n 
A 1 420 GLU 420 412 412 GLU GLU A . n 
A 1 421 LYS 421 413 413 LYS LYS A . n 
A 1 422 ILE 422 414 414 ILE ILE A . n 
A 1 423 GLN 423 415 415 GLN GLN A . n 
A 1 424 GLN 424 416 416 GLN GLN A . n 
A 1 425 TYR 425 417 417 TYR TYR A . n 
A 1 426 ASP 426 418 418 ASP ASP A . n 
A 1 427 ASN 427 419 419 ASN ASN A . n 
A 1 428 TRP 428 420 420 TRP TRP A . n 
A 1 429 ASP 429 421 421 ASP ASP A . n 
A 1 430 TRP 430 422 422 TRP TRP A . n 
A 1 431 PRO 431 423 423 PRO PRO A . n 
A 1 432 GLN 432 424 424 GLN GLN A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 GOL 1   501 501 GOL GOL A . 
C 3 CL  1   502 1   CL  CL  A . 
D 4 HOH 1   601 146 HOH HOH A . 
D 4 HOH 2   602 156 HOH HOH A . 
D 4 HOH 3   603 17  HOH HOH A . 
D 4 HOH 4   604 125 HOH HOH A . 
D 4 HOH 5   605 21  HOH HOH A . 
D 4 HOH 6   606 160 HOH HOH A . 
D 4 HOH 7   607 43  HOH HOH A . 
D 4 HOH 8   608 28  HOH HOH A . 
D 4 HOH 9   609 24  HOH HOH A . 
D 4 HOH 10  610 101 HOH HOH A . 
D 4 HOH 11  611 44  HOH HOH A . 
D 4 HOH 12  612 11  HOH HOH A . 
D 4 HOH 13  613 54  HOH HOH A . 
D 4 HOH 14  614 23  HOH HOH A . 
D 4 HOH 15  615 143 HOH HOH A . 
D 4 HOH 16  616 29  HOH HOH A . 
D 4 HOH 17  617 155 HOH HOH A . 
D 4 HOH 18  618 12  HOH HOH A . 
D 4 HOH 19  619 124 HOH HOH A . 
D 4 HOH 20  620 135 HOH HOH A . 
D 4 HOH 21  621 41  HOH HOH A . 
D 4 HOH 22  622 36  HOH HOH A . 
D 4 HOH 23  623 18  HOH HOH A . 
D 4 HOH 24  624 122 HOH HOH A . 
D 4 HOH 25  625 111 HOH HOH A . 
D 4 HOH 26  626 118 HOH HOH A . 
D 4 HOH 27  627 150 HOH HOH A . 
D 4 HOH 28  628 153 HOH HOH A . 
D 4 HOH 29  629 8   HOH HOH A . 
D 4 HOH 30  630 157 HOH HOH A . 
D 4 HOH 31  631 46  HOH HOH A . 
D 4 HOH 32  632 16  HOH HOH A . 
D 4 HOH 33  633 120 HOH HOH A . 
D 4 HOH 34  634 139 HOH HOH A . 
D 4 HOH 35  635 59  HOH HOH A . 
D 4 HOH 36  636 134 HOH HOH A . 
D 4 HOH 37  637 140 HOH HOH A . 
D 4 HOH 38  638 31  HOH HOH A . 
D 4 HOH 39  639 114 HOH HOH A . 
D 4 HOH 40  640 93  HOH HOH A . 
D 4 HOH 41  641 19  HOH HOH A . 
D 4 HOH 42  642 34  HOH HOH A . 
D 4 HOH 43  643 49  HOH HOH A . 
D 4 HOH 44  644 51  HOH HOH A . 
D 4 HOH 45  645 67  HOH HOH A . 
D 4 HOH 46  646 25  HOH HOH A . 
D 4 HOH 47  647 136 HOH HOH A . 
D 4 HOH 48  648 86  HOH HOH A . 
D 4 HOH 49  649 2   HOH HOH A . 
D 4 HOH 50  650 9   HOH HOH A . 
D 4 HOH 51  651 68  HOH HOH A . 
D 4 HOH 52  652 33  HOH HOH A . 
D 4 HOH 53  653 52  HOH HOH A . 
D 4 HOH 54  654 37  HOH HOH A . 
D 4 HOH 55  655 1   HOH HOH A . 
D 4 HOH 56  656 94  HOH HOH A . 
D 4 HOH 57  657 149 HOH HOH A . 
D 4 HOH 58  658 75  HOH HOH A . 
D 4 HOH 59  659 27  HOH HOH A . 
D 4 HOH 60  660 80  HOH HOH A . 
D 4 HOH 61  661 115 HOH HOH A . 
D 4 HOH 62  662 61  HOH HOH A . 
D 4 HOH 63  663 96  HOH HOH A . 
D 4 HOH 64  664 85  HOH HOH A . 
D 4 HOH 65  665 88  HOH HOH A . 
D 4 HOH 66  666 141 HOH HOH A . 
D 4 HOH 67  667 87  HOH HOH A . 
D 4 HOH 68  668 14  HOH HOH A . 
D 4 HOH 69  669 79  HOH HOH A . 
D 4 HOH 70  670 53  HOH HOH A . 
D 4 HOH 71  671 13  HOH HOH A . 
D 4 HOH 72  672 57  HOH HOH A . 
D 4 HOH 73  673 58  HOH HOH A . 
D 4 HOH 74  674 45  HOH HOH A . 
D 4 HOH 75  675 40  HOH HOH A . 
D 4 HOH 76  676 112 HOH HOH A . 
D 4 HOH 77  677 30  HOH HOH A . 
D 4 HOH 78  678 4   HOH HOH A . 
D 4 HOH 79  679 123 HOH HOH A . 
D 4 HOH 80  680 78  HOH HOH A . 
D 4 HOH 81  681 39  HOH HOH A . 
D 4 HOH 82  682 73  HOH HOH A . 
D 4 HOH 83  683 47  HOH HOH A . 
D 4 HOH 84  684 98  HOH HOH A . 
D 4 HOH 85  685 142 HOH HOH A . 
D 4 HOH 86  686 152 HOH HOH A . 
D 4 HOH 87  687 6   HOH HOH A . 
D 4 HOH 88  688 103 HOH HOH A . 
D 4 HOH 89  689 158 HOH HOH A . 
D 4 HOH 90  690 137 HOH HOH A . 
D 4 HOH 91  691 148 HOH HOH A . 
D 4 HOH 92  692 110 HOH HOH A . 
D 4 HOH 93  693 35  HOH HOH A . 
D 4 HOH 94  694 116 HOH HOH A . 
D 4 HOH 95  695 105 HOH HOH A . 
D 4 HOH 96  696 133 HOH HOH A . 
D 4 HOH 97  697 104 HOH HOH A . 
D 4 HOH 98  698 42  HOH HOH A . 
D 4 HOH 99  699 15  HOH HOH A . 
D 4 HOH 100 700 62  HOH HOH A . 
D 4 HOH 101 701 10  HOH HOH A . 
D 4 HOH 102 702 147 HOH HOH A . 
D 4 HOH 103 703 65  HOH HOH A . 
D 4 HOH 104 704 144 HOH HOH A . 
D 4 HOH 105 705 22  HOH HOH A . 
D 4 HOH 106 706 71  HOH HOH A . 
D 4 HOH 107 707 5   HOH HOH A . 
D 4 HOH 108 708 26  HOH HOH A . 
D 4 HOH 109 709 100 HOH HOH A . 
D 4 HOH 110 710 90  HOH HOH A . 
D 4 HOH 111 711 74  HOH HOH A . 
D 4 HOH 112 712 121 HOH HOH A . 
D 4 HOH 113 713 69  HOH HOH A . 
D 4 HOH 114 714 77  HOH HOH A . 
D 4 HOH 115 715 63  HOH HOH A . 
D 4 HOH 116 716 64  HOH HOH A . 
D 4 HOH 117 717 91  HOH HOH A . 
D 4 HOH 118 718 32  HOH HOH A . 
D 4 HOH 119 719 117 HOH HOH A . 
D 4 HOH 120 720 20  HOH HOH A . 
D 4 HOH 121 721 3   HOH HOH A . 
D 4 HOH 122 722 97  HOH HOH A . 
D 4 HOH 123 723 76  HOH HOH A . 
D 4 HOH 124 724 128 HOH HOH A . 
D 4 HOH 125 725 66  HOH HOH A . 
D 4 HOH 126 726 151 HOH HOH A . 
D 4 HOH 127 727 82  HOH HOH A . 
D 4 HOH 128 728 84  HOH HOH A . 
D 4 HOH 129 729 154 HOH HOH A . 
D 4 HOH 130 730 50  HOH HOH A . 
D 4 HOH 131 731 138 HOH HOH A . 
D 4 HOH 132 732 38  HOH HOH A . 
D 4 HOH 133 733 89  HOH HOH A . 
D 4 HOH 134 734 119 HOH HOH A . 
D 4 HOH 135 735 109 HOH HOH A . 
D 4 HOH 136 736 159 HOH HOH A . 
D 4 HOH 137 737 7   HOH HOH A . 
D 4 HOH 138 738 107 HOH HOH A . 
D 4 HOH 139 739 127 HOH HOH A . 
D 4 HOH 140 740 129 HOH HOH A . 
D 4 HOH 141 741 55  HOH HOH A . 
D 4 HOH 142 742 132 HOH HOH A . 
D 4 HOH 143 743 56  HOH HOH A . 
D 4 HOH 144 744 83  HOH HOH A . 
D 4 HOH 145 745 70  HOH HOH A . 
D 4 HOH 146 746 126 HOH HOH A . 
D 4 HOH 147 747 60  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.15.2_3472 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   91.123 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZVB 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     49.381 
_cell.length_a_esd                 ? 
_cell.length_b                     64.736 
_cell.length_b_esd                 ? 
_cell.length_c                     64.473 
_cell.length_c_esd                 ? 
_cell.volume                       206063.085 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZVB 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZVB 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.15 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          42.76 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '20%PEG 6000, 0.1M MES pH6.2' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-08-29 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97915 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97915 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          23.73 
_reflns.entry_id                                       8ZVB 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.04 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     25046 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.7 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.966 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.09 
_reflns_shell.d_res_low                                     2.12 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1195 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.802 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               27.17 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZVB 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.04 
_refine.ls_d_res_low                             39.57 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     22594 
_refine.ls_number_reflns_R_free                  934 
_refine.ls_number_reflns_R_work                  21660 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    87.24 
_refine.ls_percent_reflns_R_free                 4.13 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1936 
_refine.ls_R_factor_R_free                       0.2236 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1922 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.5765 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2445 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.04 
_refine_hist.d_res_low                        39.57 
_refine_hist.number_atoms_solvent             147 
_refine_hist.number_atoms_total               3329 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3175 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         7 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0067 ? 3269 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5898 ? 4437 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0486 ? 490  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0041 ? 566  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 4.4070 ? 2699 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.04 2.15  . . 55  1745 48.67 . . . . 0.2228 . . . . . . . . . . . 0.3003 
'X-RAY DIFFRACTION' 2.15 2.29  . . 93  2741 77.52 . . . . 0.2193 . . . . . . . . . . . 0.2428 
'X-RAY DIFFRACTION' 2.29 2.46  . . 132 3330 93.90 . . . . 0.2157 . . . . . . . . . . . 0.2768 
'X-RAY DIFFRACTION' 2.46 2.71  . . 147 3483 98.45 . . . . 0.2123 . . . . . . . . . . . 0.2938 
'X-RAY DIFFRACTION' 2.71 3.10  . . 170 3475 98.86 . . . . 0.2056 . . . . . . . . . . . 0.2399 
'X-RAY DIFFRACTION' 3.10 3.91  . . 175 3444 97.78 . . . . 0.1842 . . . . . . . . . . . 0.2156 
'X-RAY DIFFRACTION' 3.91 39.57 . . 162 3442 95.29 . . . . 0.1666 . . . . . . . . . . . 0.1789 
# 
_struct.entry_id                     8ZVB 
_struct.title                        'The ShosTA toxin-antitoxin system provides phage defence' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZVB 
_struct_keywords.text            'ShosT, toxin, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A0H2Z117_ECOK1 
_struct_ref.pdbx_db_accession          A0A0H2Z117 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MNNMYLKAVIFSIADVVLPLTSNTQPQELKSRIDSELRKLFAFLSSKGIKVIFLTNKNRNVRTHDGIVTLDEYLKRKFPE
SIHFCRELDNNIPAKQTGKAIDFIMAALELKRNEMIYVGRSQEDLQAATNGNTLFINATWYEPVTEYGFQFSEPKEIARF
IDVFCLREQLWGWQGHFNEDVHYYALAPFSTYVPEFTMYSANARDLAKLSVGSPDFWIRYLGASIYFSGLSEGASFITTY
VGHNAEDPYKLANIMEHDLKGLAVSFKGKYLKDLFLRHTTAIKSQQARIAKQEVNITSQINTVNLNPAPIKNLITGERYT
NPPKLKGKKILVIDDFCTEGNAHETARMYLKAAGANVINISWLKTINRDVSICEPTRKIRPWEANTLDVDDINYVGTIGY
AENVTHGSAPQVLSEKIQQYDNWDWPQ
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8ZVB 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 6 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 432 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A0H2Z117 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  427 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       -2 
_struct_ref_seq.pdbx_auth_seq_align_end       424 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZVB GLY A 1 ? UNP A0A0H2Z117 ? ? 'expression tag' -7 1 
1 8ZVB ALA A 2 ? UNP A0A0H2Z117 ? ? 'expression tag' -6 2 
1 8ZVB SER A 3 ? UNP A0A0H2Z117 ? ? 'expression tag' -5 3 
1 8ZVB GLY A 4 ? UNP A0A0H2Z117 ? ? 'expression tag' -4 4 
1 8ZVB SER A 5 ? UNP A0A0H2Z117 ? ? 'expression tag' -3 5 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 150   ? 
1 MORE         -10   ? 
1 'SSA (A^2)'  17850 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 31  ? LYS A 52  ? PRO A 23  LYS A 44  1 ? 22 
HELX_P HELX_P2  AA2 LEU A 75  ? PHE A 83  ? LEU A 67  PHE A 75  1 ? 9  
HELX_P HELX_P3  AA3 GLU A 92  ? ASP A 94  ? GLU A 84  ASP A 86  5 ? 3  
HELX_P HELX_P4  AA4 ALA A 99  ? THR A 102 ? ALA A 91  THR A 94  5 ? 4  
HELX_P HELX_P5  AA5 GLY A 103 ? GLU A 114 ? GLY A 95  GLU A 106 1 ? 12 
HELX_P HELX_P6  AA6 LYS A 116 ? ASN A 118 ? LYS A 108 ASN A 110 5 ? 3  
HELX_P HELX_P7  AA7 SER A 126 ? GLY A 136 ? SER A 118 GLY A 128 1 ? 11 
HELX_P HELX_P8  AA8 GLU A 158 ? CYS A 170 ? GLU A 150 CYS A 162 1 ? 13 
HELX_P HELX_P9  AA9 SER A 218 ? SER A 233 ? SER A 210 SER A 225 1 ? 16 
HELX_P HELX_P10 AB1 TYR A 254 ? LYS A 272 ? TYR A 246 LYS A 264 1 ? 19 
HELX_P HELX_P11 AB2 ILE A 301 ? ASN A 306 ? ILE A 293 ASN A 298 1 ? 6  
HELX_P HELX_P12 AB3 GLY A 345 ? ALA A 358 ? GLY A 337 ALA A 350 1 ? 14 
HELX_P HELX_P13 AB4 ASP A 393 ? ASP A 395 ? ASP A 385 ASP A 387 5 ? 3  
HELX_P HELX_P14 AB5 LEU A 418 ? ASN A 427 ? LEU A 410 ASN A 419 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 2 ? 
AA3 ? 6 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
AA6 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? parallel      
AA3 3 4 ? parallel      
AA3 4 5 ? parallel      
AA3 5 6 ? parallel      
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 87  ? CYS A 90  ? ILE A 79  CYS A 82  
AA1 2 LYS A 55  ? THR A 60  ? LYS A 47  THR A 52  
AA1 3 ALA A 13  ? PHE A 16  ? ALA A 5   PHE A 8   
AA1 4 MET A 120 ? GLY A 124 ? MET A 112 GLY A 116 
AA1 5 LEU A 139 ? ALA A 143 ? LEU A 131 ALA A 135 
AA1 6 GLN A 155 ? PHE A 156 ? GLN A 147 PHE A 148 
AA2 1 ASN A 65  ? ARG A 67  ? ASN A 57  ARG A 59  
AA2 2 ILE A 72  ? THR A 74  ? ILE A 64  THR A 66  
AA3 1 TRP A 178 ? PHE A 182 ? TRP A 170 PHE A 174 
AA3 2 VAL A 186 ? PHE A 194 ? VAL A 178 PHE A 186 
AA3 3 ASN A 361 ? THR A 370 ? ASN A 353 THR A 362 
AA3 4 LYS A 334 ? CYS A 342 ? LYS A 326 CYS A 334 
AA3 5 ALA A 239 ? THR A 244 ? ALA A 231 THR A 236 
AA3 6 LYS A 274 ? LEU A 276 ? LYS A 266 LEU A 268 
AA4 1 PHE A 280 ? ARG A 282 ? PHE A 272 ARG A 274 
AA4 2 VAL A 308 ? LEU A 310 ? VAL A 300 LEU A 302 
AA5 1 ILE A 315 ? ASN A 317 ? ILE A 307 ASN A 309 
AA5 2 GLU A 322 ? ARG A 323 ? GLU A 314 ARG A 315 
AA6 1 VAL A 375 ? PRO A 380 ? VAL A 367 PRO A 372 
AA6 2 ILE A 397 ? ILE A 403 ? ILE A 389 ILE A 395 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O ILE A 87  ? O ILE A 79  N PHE A 58  ? N PHE A 50  
AA1 2 3 O ILE A 57  ? O ILE A 49  N PHE A 16  ? N PHE A 8   
AA1 3 4 N ILE A 15  ? N ILE A 7   O VAL A 123 ? O VAL A 115 
AA1 4 5 N TYR A 122 ? N TYR A 114 O ILE A 141 ? O ILE A 133 
AA1 5 6 N ASN A 142 ? N ASN A 134 O PHE A 156 ? O PHE A 148 
AA2 1 2 N VAL A 66  ? N VAL A 58  O VAL A 73  ? O VAL A 65  
AA3 1 2 N GLY A 180 ? N GLY A 172 O TYR A 188 ? O TYR A 180 
AA3 2 3 N PHE A 194 ? N PHE A 186 O LYS A 369 ? O LYS A 361 
AA3 3 4 O ILE A 365 ? O ILE A 357 N VAL A 337 ? N VAL A 329 
AA3 4 5 O ILE A 338 ? O ILE A 330 N THR A 243 ? N THR A 235 
AA3 5 6 N ILE A 242 ? N ILE A 234 O LEU A 276 ? O LEU A 268 
AA4 1 2 N LEU A 281 ? N LEU A 273 O ASN A 309 ? O ASN A 301 
AA5 1 2 N LYS A 316 ? N LYS A 308 O GLU A 322 ? O GLU A 314 
AA6 1 2 N GLU A 379 ? N GLU A 371 O ASN A 398 ? O ASN A 390 
# 
_pdbx_entry_details.entry_id                   8ZVB 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 HD21 A ASN 127 ? ? HZ1 A LYS 264 ? ? 1.20 
2 1 OD1  A ASP 212 ? ? O   A HOH 601 ? ? 1.98 
3 1 O    A HOH 684 ? ? O   A HOH 720 ? ? 2.01 
4 1 O    A HOH 720 ? ? O   A HOH 738 ? ? 2.14 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 HH22 A ARG 59 ? ? 1_555 OD1 A ASP 387 ? ? 1_456 1.42 
2 1 NH2  A ARG 59 ? ? 1_555 OD1 A ASP 387 ? ? 1_456 2.16 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 VAL A 13  ? ? -126.31 -66.70  
2 1 THR A 21  ? ? -109.04 52.01   
3 1 ARG A 117 ? ? -140.40 -43.89  
4 1 ASN A 175 ? ? 51.10   -150.44 
5 1 ASP A 244 ? ? -156.33 68.56   
6 1 THR A 335 ? ? -105.70 -78.34  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -x,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY -7  ? A GLY 1   
2  1 Y 1 A ALA -6  ? A ALA 2   
3  1 Y 1 A SER -5  ? A SER 3   
4  1 Y 1 A GLY -4  ? A GLY 4   
5  1 Y 1 A SER -3  ? A SER 5   
6  1 Y 1 A MET -2  ? A MET 6   
7  1 Y 1 A ASN -1  ? A ASN 7   
8  1 Y 1 A ASN 0   ? A ASN 8   
9  1 Y 1 A GLU 192 ? A GLU 200 
10 1 Y 1 A PHE 193 ? A PHE 201 
11 1 Y 1 A THR 194 ? A THR 202 
12 1 Y 1 A MET 195 ? A MET 203 
13 1 Y 1 A TYR 196 ? A TYR 204 
14 1 Y 1 A SER 197 ? A SER 205 
15 1 Y 1 A ALA 198 ? A ALA 206 
16 1 Y 1 A ASN 199 ? A ASN 207 
17 1 Y 1 A ALA 200 ? A ALA 208 
18 1 Y 1 A ARG 201 ? A ARG 209 
19 1 Y 1 A ASP 202 ? A ASP 210 
20 1 Y 1 A LEU 203 ? A LEU 211 
21 1 Y 1 A ALA 204 ? A ALA 212 
22 1 Y 1 A LYS 205 ? A LYS 213 
23 1 Y 1 A ILE 279 ? A ILE 287 
24 1 Y 1 A LYS 280 ? A LYS 288 
25 1 Y 1 A SER 281 ? A SER 289 
26 1 Y 1 A GLN 282 ? A GLN 290 
27 1 Y 1 A GLN 283 ? A GLN 291 
28 1 Y 1 A ALA 284 ? A ALA 292 
29 1 Y 1 A ARG 285 ? A ARG 293 
30 1 Y 1 A ILE 286 ? A ILE 294 
31 1 Y 1 A ALA 287 ? A ALA 295 
32 1 Y 1 A LYS 288 ? A LYS 296 
33 1 Y 1 A GLN 289 ? A GLN 297 
34 1 Y 1 A GLU 290 ? A GLU 298 
35 1 Y 1 A GLY 404 ? A GLY 412 
36 1 Y 1 A SER 405 ? A SER 413 
37 1 Y 1 A ALA 406 ? A ALA 414 
38 1 Y 1 A PRO 407 ? A PRO 415 
39 1 Y 1 A GLN 408 ? A GLN 416 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
GOL C1   C  N N 138 
GOL O1   O  N N 139 
GOL C2   C  N N 140 
GOL O2   O  N N 141 
GOL C3   C  N N 142 
GOL O3   O  N N 143 
GOL H11  H  N N 144 
GOL H12  H  N N 145 
GOL HO1  H  N N 146 
GOL H2   H  N N 147 
GOL HO2  H  N N 148 
GOL H31  H  N N 149 
GOL H32  H  N N 150 
GOL HO3  H  N N 151 
HIS N    N  N N 152 
HIS CA   C  N S 153 
HIS C    C  N N 154 
HIS O    O  N N 155 
HIS CB   C  N N 156 
HIS CG   C  Y N 157 
HIS ND1  N  Y N 158 
HIS CD2  C  Y N 159 
HIS CE1  C  Y N 160 
HIS NE2  N  Y N 161 
HIS OXT  O  N N 162 
HIS H    H  N N 163 
HIS H2   H  N N 164 
HIS HA   H  N N 165 
HIS HB2  H  N N 166 
HIS HB3  H  N N 167 
HIS HD1  H  N N 168 
HIS HD2  H  N N 169 
HIS HE1  H  N N 170 
HIS HE2  H  N N 171 
HIS HXT  H  N N 172 
HOH O    O  N N 173 
HOH H1   H  N N 174 
HOH H2   H  N N 175 
ILE N    N  N N 176 
ILE CA   C  N S 177 
ILE C    C  N N 178 
ILE O    O  N N 179 
ILE CB   C  N S 180 
ILE CG1  C  N N 181 
ILE CG2  C  N N 182 
ILE CD1  C  N N 183 
ILE OXT  O  N N 184 
ILE H    H  N N 185 
ILE H2   H  N N 186 
ILE HA   H  N N 187 
ILE HB   H  N N 188 
ILE HG12 H  N N 189 
ILE HG13 H  N N 190 
ILE HG21 H  N N 191 
ILE HG22 H  N N 192 
ILE HG23 H  N N 193 
ILE HD11 H  N N 194 
ILE HD12 H  N N 195 
ILE HD13 H  N N 196 
ILE HXT  H  N N 197 
LEU N    N  N N 198 
LEU CA   C  N S 199 
LEU C    C  N N 200 
LEU O    O  N N 201 
LEU CB   C  N N 202 
LEU CG   C  N N 203 
LEU CD1  C  N N 204 
LEU CD2  C  N N 205 
LEU OXT  O  N N 206 
LEU H    H  N N 207 
LEU H2   H  N N 208 
LEU HA   H  N N 209 
LEU HB2  H  N N 210 
LEU HB3  H  N N 211 
LEU HG   H  N N 212 
LEU HD11 H  N N 213 
LEU HD12 H  N N 214 
LEU HD13 H  N N 215 
LEU HD21 H  N N 216 
LEU HD22 H  N N 217 
LEU HD23 H  N N 218 
LEU HXT  H  N N 219 
LYS N    N  N N 220 
LYS CA   C  N S 221 
LYS C    C  N N 222 
LYS O    O  N N 223 
LYS CB   C  N N 224 
LYS CG   C  N N 225 
LYS CD   C  N N 226 
LYS CE   C  N N 227 
LYS NZ   N  N N 228 
LYS OXT  O  N N 229 
LYS H    H  N N 230 
LYS H2   H  N N 231 
LYS HA   H  N N 232 
LYS HB2  H  N N 233 
LYS HB3  H  N N 234 
LYS HG2  H  N N 235 
LYS HG3  H  N N 236 
LYS HD2  H  N N 237 
LYS HD3  H  N N 238 
LYS HE2  H  N N 239 
LYS HE3  H  N N 240 
LYS HZ1  H  N N 241 
LYS HZ2  H  N N 242 
LYS HZ3  H  N N 243 
LYS HXT  H  N N 244 
MET N    N  N N 245 
MET CA   C  N S 246 
MET C    C  N N 247 
MET O    O  N N 248 
MET CB   C  N N 249 
MET CG   C  N N 250 
MET SD   S  N N 251 
MET CE   C  N N 252 
MET OXT  O  N N 253 
MET H    H  N N 254 
MET H2   H  N N 255 
MET HA   H  N N 256 
MET HB2  H  N N 257 
MET HB3  H  N N 258 
MET HG2  H  N N 259 
MET HG3  H  N N 260 
MET HE1  H  N N 261 
MET HE2  H  N N 262 
MET HE3  H  N N 263 
MET HXT  H  N N 264 
PHE N    N  N N 265 
PHE CA   C  N S 266 
PHE C    C  N N 267 
PHE O    O  N N 268 
PHE CB   C  N N 269 
PHE CG   C  Y N 270 
PHE CD1  C  Y N 271 
PHE CD2  C  Y N 272 
PHE CE1  C  Y N 273 
PHE CE2  C  Y N 274 
PHE CZ   C  Y N 275 
PHE OXT  O  N N 276 
PHE H    H  N N 277 
PHE H2   H  N N 278 
PHE HA   H  N N 279 
PHE HB2  H  N N 280 
PHE HB3  H  N N 281 
PHE HD1  H  N N 282 
PHE HD2  H  N N 283 
PHE HE1  H  N N 284 
PHE HE2  H  N N 285 
PHE HZ   H  N N 286 
PHE HXT  H  N N 287 
PRO N    N  N N 288 
PRO CA   C  N S 289 
PRO C    C  N N 290 
PRO O    O  N N 291 
PRO CB   C  N N 292 
PRO CG   C  N N 293 
PRO CD   C  N N 294 
PRO OXT  O  N N 295 
PRO H    H  N N 296 
PRO HA   H  N N 297 
PRO HB2  H  N N 298 
PRO HB3  H  N N 299 
PRO HG2  H  N N 300 
PRO HG3  H  N N 301 
PRO HD2  H  N N 302 
PRO HD3  H  N N 303 
PRO HXT  H  N N 304 
SER N    N  N N 305 
SER CA   C  N S 306 
SER C    C  N N 307 
SER O    O  N N 308 
SER CB   C  N N 309 
SER OG   O  N N 310 
SER OXT  O  N N 311 
SER H    H  N N 312 
SER H2   H  N N 313 
SER HA   H  N N 314 
SER HB2  H  N N 315 
SER HB3  H  N N 316 
SER HG   H  N N 317 
SER HXT  H  N N 318 
THR N    N  N N 319 
THR CA   C  N S 320 
THR C    C  N N 321 
THR O    O  N N 322 
THR CB   C  N R 323 
THR OG1  O  N N 324 
THR CG2  C  N N 325 
THR OXT  O  N N 326 
THR H    H  N N 327 
THR H2   H  N N 328 
THR HA   H  N N 329 
THR HB   H  N N 330 
THR HG1  H  N N 331 
THR HG21 H  N N 332 
THR HG22 H  N N 333 
THR HG23 H  N N 334 
THR HXT  H  N N 335 
TRP N    N  N N 336 
TRP CA   C  N S 337 
TRP C    C  N N 338 
TRP O    O  N N 339 
TRP CB   C  N N 340 
TRP CG   C  Y N 341 
TRP CD1  C  Y N 342 
TRP CD2  C  Y N 343 
TRP NE1  N  Y N 344 
TRP CE2  C  Y N 345 
TRP CE3  C  Y N 346 
TRP CZ2  C  Y N 347 
TRP CZ3  C  Y N 348 
TRP CH2  C  Y N 349 
TRP OXT  O  N N 350 
TRP H    H  N N 351 
TRP H2   H  N N 352 
TRP HA   H  N N 353 
TRP HB2  H  N N 354 
TRP HB3  H  N N 355 
TRP HD1  H  N N 356 
TRP HE1  H  N N 357 
TRP HE3  H  N N 358 
TRP HZ2  H  N N 359 
TRP HZ3  H  N N 360 
TRP HH2  H  N N 361 
TRP HXT  H  N N 362 
TYR N    N  N N 363 
TYR CA   C  N S 364 
TYR C    C  N N 365 
TYR O    O  N N 366 
TYR CB   C  N N 367 
TYR CG   C  Y N 368 
TYR CD1  C  Y N 369 
TYR CD2  C  Y N 370 
TYR CE1  C  Y N 371 
TYR CE2  C  Y N 372 
TYR CZ   C  Y N 373 
TYR OH   O  N N 374 
TYR OXT  O  N N 375 
TYR H    H  N N 376 
TYR H2   H  N N 377 
TYR HA   H  N N 378 
TYR HB2  H  N N 379 
TYR HB3  H  N N 380 
TYR HD1  H  N N 381 
TYR HD2  H  N N 382 
TYR HE1  H  N N 383 
TYR HE2  H  N N 384 
TYR HH   H  N N 385 
TYR HXT  H  N N 386 
VAL N    N  N N 387 
VAL CA   C  N S 388 
VAL C    C  N N 389 
VAL O    O  N N 390 
VAL CB   C  N N 391 
VAL CG1  C  N N 392 
VAL CG2  C  N N 393 
VAL OXT  O  N N 394 
VAL H    H  N N 395 
VAL H2   H  N N 396 
VAL HA   H  N N 397 
VAL HB   H  N N 398 
VAL HG11 H  N N 399 
VAL HG12 H  N N 400 
VAL HG13 H  N N 401 
VAL HG21 H  N N 402 
VAL HG22 H  N N 403 
VAL HG23 H  N N 404 
VAL HXT  H  N N 405 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
MET N   CA   sing N N 231 
MET N   H    sing N N 232 
MET N   H2   sing N N 233 
MET CA  C    sing N N 234 
MET CA  CB   sing N N 235 
MET CA  HA   sing N N 236 
MET C   O    doub N N 237 
MET C   OXT  sing N N 238 
MET CB  CG   sing N N 239 
MET CB  HB2  sing N N 240 
MET CB  HB3  sing N N 241 
MET CG  SD   sing N N 242 
MET CG  HG2  sing N N 243 
MET CG  HG3  sing N N 244 
MET SD  CE   sing N N 245 
MET CE  HE1  sing N N 246 
MET CE  HE2  sing N N 247 
MET CE  HE3  sing N N 248 
MET OXT HXT  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PRO N   CA   sing N N 273 
PRO N   CD   sing N N 274 
PRO N   H    sing N N 275 
PRO CA  C    sing N N 276 
PRO CA  CB   sing N N 277 
PRO CA  HA   sing N N 278 
PRO C   O    doub N N 279 
PRO C   OXT  sing N N 280 
PRO CB  CG   sing N N 281 
PRO CB  HB2  sing N N 282 
PRO CB  HB3  sing N N 283 
PRO CG  CD   sing N N 284 
PRO CG  HG2  sing N N 285 
PRO CG  HG3  sing N N 286 
PRO CD  HD2  sing N N 287 
PRO CD  HD3  sing N N 288 
PRO OXT HXT  sing N N 289 
SER N   CA   sing N N 290 
SER N   H    sing N N 291 
SER N   H2   sing N N 292 
SER CA  C    sing N N 293 
SER CA  CB   sing N N 294 
SER CA  HA   sing N N 295 
SER C   O    doub N N 296 
SER C   OXT  sing N N 297 
SER CB  OG   sing N N 298 
SER CB  HB2  sing N N 299 
SER CB  HB3  sing N N 300 
SER OG  HG   sing N N 301 
SER OXT HXT  sing N N 302 
THR N   CA   sing N N 303 
THR N   H    sing N N 304 
THR N   H2   sing N N 305 
THR CA  C    sing N N 306 
THR CA  CB   sing N N 307 
THR CA  HA   sing N N 308 
THR C   O    doub N N 309 
THR C   OXT  sing N N 310 
THR CB  OG1  sing N N 311 
THR CB  CG2  sing N N 312 
THR CB  HB   sing N N 313 
THR OG1 HG1  sing N N 314 
THR CG2 HG21 sing N N 315 
THR CG2 HG22 sing N N 316 
THR CG2 HG23 sing N N 317 
THR OXT HXT  sing N N 318 
TRP N   CA   sing N N 319 
TRP N   H    sing N N 320 
TRP N   H2   sing N N 321 
TRP CA  C    sing N N 322 
TRP CA  CB   sing N N 323 
TRP CA  HA   sing N N 324 
TRP C   O    doub N N 325 
TRP C   OXT  sing N N 326 
TRP CB  CG   sing N N 327 
TRP CB  HB2  sing N N 328 
TRP CB  HB3  sing N N 329 
TRP CG  CD1  doub Y N 330 
TRP CG  CD2  sing Y N 331 
TRP CD1 NE1  sing Y N 332 
TRP CD1 HD1  sing N N 333 
TRP CD2 CE2  doub Y N 334 
TRP CD2 CE3  sing Y N 335 
TRP NE1 CE2  sing Y N 336 
TRP NE1 HE1  sing N N 337 
TRP CE2 CZ2  sing Y N 338 
TRP CE3 CZ3  doub Y N 339 
TRP CE3 HE3  sing N N 340 
TRP CZ2 CH2  doub Y N 341 
TRP CZ2 HZ2  sing N N 342 
TRP CZ3 CH2  sing Y N 343 
TRP CZ3 HZ3  sing N N 344 
TRP CH2 HH2  sing N N 345 
TRP OXT HXT  sing N N 346 
TYR N   CA   sing N N 347 
TYR N   H    sing N N 348 
TYR N   H2   sing N N 349 
TYR CA  C    sing N N 350 
TYR CA  CB   sing N N 351 
TYR CA  HA   sing N N 352 
TYR C   O    doub N N 353 
TYR C   OXT  sing N N 354 
TYR CB  CG   sing N N 355 
TYR CB  HB2  sing N N 356 
TYR CB  HB3  sing N N 357 
TYR CG  CD1  doub Y N 358 
TYR CG  CD2  sing Y N 359 
TYR CD1 CE1  sing Y N 360 
TYR CD1 HD1  sing N N 361 
TYR CD2 CE2  doub Y N 362 
TYR CD2 HD2  sing N N 363 
TYR CE1 CZ   doub Y N 364 
TYR CE1 HE1  sing N N 365 
TYR CE2 CZ   sing Y N 366 
TYR CE2 HE2  sing N N 367 
TYR CZ  OH   sing N N 368 
TYR OH  HH   sing N N 369 
TYR OXT HXT  sing N N 370 
VAL N   CA   sing N N 371 
VAL N   H    sing N N 372 
VAL N   H2   sing N N 373 
VAL CA  C    sing N N 374 
VAL CA  CB   sing N N 375 
VAL CA  HA   sing N N 376 
VAL C   O    doub N N 377 
VAL C   OXT  sing N N 378 
VAL CB  CG1  sing N N 379 
VAL CB  CG2  sing N N 380 
VAL CB  HB   sing N N 381 
VAL CG1 HG11 sing N N 382 
VAL CG1 HG12 sing N N 383 
VAL CG1 HG13 sing N N 384 
VAL CG2 HG21 sing N N 385 
VAL CG2 HG22 sing N N 386 
VAL CG2 HG23 sing N N 387 
VAL OXT HXT  sing N N 388 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 1 21 1' 
_space_group.name_Hall        'P 2yb' 
_space_group.IT_number        4 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8ZVB 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.020251 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000397 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015447 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.015513 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761 7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H  ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N    . MET A 1 9   ? 20.85388  7.33417   21.38763  1.000 38.54874  ? 1   MET A N    1 
ATOM   2    C  CA   . MET A 1 9   ? 20.87123  8.71952   20.84958  1.000 42.58062  ? 1   MET A CA   1 
ATOM   3    C  C    . MET A 1 9   ? 19.74276  8.94099   19.84410  1.000 37.46305  ? 1   MET A C    1 
ATOM   4    O  O    . MET A 1 9   ? 19.30276  10.06730  19.62382  1.000 44.66876  ? 1   MET A O    1 
ATOM   5    C  CB   . MET A 1 9   ? 22.21457  9.02097   20.18480  1.000 45.87423  ? 1   MET A CB   1 
ATOM   6    C  CG   . MET A 1 9   ? 22.70745  7.93554   19.23228  1.000 51.51339  ? 1   MET A CG   1 
ATOM   7    S  SD   . MET A 1 9   ? 24.06591  8.49209   18.17991  1.000 74.56362  ? 1   MET A SD   1 
ATOM   8    C  CE   . MET A 1 9   ? 23.23515  9.70355   17.14292  1.000 44.56902  ? 1   MET A CE   1 
ATOM   9    H  H    . MET A 1 9   ? 21.28546  7.31270   22.16569  1.000 46.23530  ? 1   MET A H    1 
ATOM   10   H  HA   . MET A 1 9   ? 20.75478  9.33362   21.59135  1.000 51.07355  ? 1   MET A HA   1 
ATOM   11   H  HB2  . MET A 1 9   ? 22.12948  9.84166   19.67477  1.000 55.02588  ? 1   MET A HB2  1 
ATOM   12   H  HB3  . MET A 1 9   ? 22.88472  9.12895   20.87772  1.000 55.02588  ? 1   MET A HB3  1 
ATOM   13   H  HG2  . MET A 1 9   ? 23.02103  7.17840   19.75123  1.000 61.79288  ? 1   MET A HG2  1 
ATOM   14   H  HG3  . MET A 1 9   ? 21.97508  7.66327   18.65748  1.000 61.79288  ? 1   MET A HG3  1 
ATOM   15   H  HE1  . MET A 1 9   ? 23.83616  9.97579   16.43189  1.000 53.45963  ? 1   MET A HE1  1 
ATOM   16   H  HE2  . MET A 1 9   ? 22.43688  9.30190   16.76564  1.000 53.45963  ? 1   MET A HE2  1 
ATOM   17   H  HE3  . MET A 1 9   ? 22.99468  10.47126  17.68486  1.000 53.45963  ? 1   MET A HE3  1 
ATOM   18   N  N    . TYR A 1 10  ? 19.27363  7.85711   19.22628  1.000 29.13230  ? 2   TYR A N    1 
ATOM   19   C  CA   . TYR A 1 10  ? 18.21300  7.96756   18.23038  1.000 25.78761  ? 2   TYR A CA   1 
ATOM   20   C  C    . TYR A 1 10  ? 16.82883  7.97510   18.86099  1.000 22.00933  ? 2   TYR A C    1 
ATOM   21   O  O    . TYR A 1 10  ? 16.05785  8.90927   18.62884  1.000 21.79945  ? 2   TYR A O    1 
ATOM   22   C  CB   . TYR A 1 10  ? 18.31284  6.82856   17.22061  1.000 24.69117  ? 2   TYR A CB   1 
ATOM   23   C  CG   . TYR A 1 10  ? 19.56869  6.88017   16.38664  1.000 24.84187  ? 2   TYR A CG   1 
ATOM   24   C  CD1  . TYR A 1 10  ? 19.76910  7.89774   15.46862  1.000 26.47802  ? 2   TYR A CD1  1 
ATOM   25   C  CD2  . TYR A 1 10  ? 20.56387  5.92337   16.53443  1.000 23.98261  ? 2   TYR A CD2  1 
ATOM   26   C  CE1  . TYR A 1 10  ? 20.92195  7.95541   14.70962  1.000 32.02996  ? 2   TYR A CE1  1 
ATOM   27   C  CE2  . TYR A 1 10  ? 21.71330  5.96968   15.78388  1.000 29.95393  ? 2   TYR A CE2  1 
ATOM   28   C  CZ   . TYR A 1 10  ? 21.88814  6.98736   14.87166  1.000 26.59996  ? 2   TYR A CZ   1 
ATOM   29   O  OH   . TYR A 1 10  ? 23.03346  7.04273   14.12047  1.000 30.82395  ? 2   TYR A OH   1 
ATOM   30   H  H    . TYR A 1 10  ? 19.55144  7.05533   19.36616  1.000 34.93558  ? 2   TYR A H    1 
ATOM   31   H  HA   . TYR A 1 10  ? 18.33298  8.80496   17.75576  1.000 30.92194  ? 2   TYR A HA   1 
ATOM   32   H  HB2  . TYR A 1 10  ? 18.30656  5.98434   17.69826  1.000 29.60622  ? 2   TYR A HB2  1 
ATOM   33   H  HB3  . TYR A 1 10  ? 17.55330  6.87505   16.61908  1.000 29.60622  ? 2   TYR A HB3  1 
ATOM   34   H  HD1  . TYR A 1 10  ? 19.11734  8.55245   15.36149  1.000 31.75043  ? 2   TYR A HD1  1 
ATOM   35   H  HD2  . TYR A 1 10  ? 20.45011  5.23839   17.15311  1.000 28.75594  ? 2   TYR A HD2  1 
ATOM   36   H  HE1  . TYR A 1 10  ? 21.04459  8.64206   14.09450  1.000 38.41277  ? 2   TYR A HE1  1 
ATOM   37   H  HE2  . TYR A 1 10  ? 22.36887  5.31874   15.89067  1.000 35.92153  ? 2   TYR A HE2  1 
ATOM   38   H  HH   . TYR A 1 10  ? 23.49374  6.35155   14.24702  1.000 36.96555  ? 2   TYR A HH   1 
ATOM   39   N  N    . LEU A 1 11  ? 16.51415  6.96990   19.67874  1.000 19.25174  ? 3   LEU A N    1 
ATOM   40   C  CA   . LEU A 1 11  ? 15.20388  6.85761   20.30411  1.000 20.73716  ? 3   LEU A CA   1 
ATOM   41   C  C    . LEU A 1 11  ? 15.22328  7.51815   21.67644  1.000 21.12527  ? 3   LEU A C    1 
ATOM   42   O  O    . LEU A 1 11  ? 16.01772  7.14234   22.54831  1.000 17.11955  ? 3   LEU A O    1 
ATOM   43   C  CB   . LEU A 1 11  ? 14.79425  5.39504   20.42865  1.000 17.44165  ? 3   LEU A CB   1 
ATOM   44   C  CG   . LEU A 1 11  ? 13.39937  5.18037   21.00062  1.000 17.54729  ? 3   LEU A CG   1 
ATOM   45   C  CD1  . LEU A 1 11  ? 12.33901  5.84533   20.16537  1.000 15.00621  ? 3   LEU A CD1  1 
ATOM   46   C  CD2  . LEU A 1 11  ? 13.12199  3.65491   21.09847  1.000 15.72011  ? 3   LEU A CD2  1 
ATOM   47   H  H    . LEU A 1 11  ? 17.05297  6.33303   19.88770  1.000 23.07890  ? 3   LEU A H    1 
ATOM   48   H  HA   . LEU A 1 11  ? 14.55288  7.32061   19.75391  1.000 24.86141  ? 3   LEU A HA   1 
ATOM   49   H  HB2  . LEU A 1 11  ? 14.81586  4.99204   19.54660  1.000 20.90680  ? 3   LEU A HB2  1 
ATOM   50   H  HB3  . LEU A 1 11  ? 15.42452  4.94651   21.01387  1.000 20.90680  ? 3   LEU A HB3  1 
ATOM   51   H  HG   . LEU A 1 11  ? 13.35679  5.58259   21.88227  1.000 21.03355  ? 3   LEU A HG   1 
ATOM   52   H  HD11 . LEU A 1 11  ? 11.46816  5.64577   20.54314  1.000 17.98426  ? 3   LEU A HD11 1 
ATOM   53   H  HD12 . LEU A 1 11  ? 12.48926  6.80362   20.16861  1.000 17.98426  ? 3   LEU A HD12 1 
ATOM   54   H  HD13 . LEU A 1 11  ? 12.39197  5.50527   19.25848  1.000 17.98426  ? 3   LEU A HD13 1 
ATOM   55   H  HD21 . LEU A 1 11  ? 12.22981  3.51831   21.45378  1.000 18.84095  ? 3   LEU A HD21 1 
ATOM   56   H  HD22 . LEU A 1 11  ? 13.18882  3.26435   20.21309  1.000 18.84095  ? 3   LEU A HD22 1 
ATOM   57   H  HD23 . LEU A 1 11  ? 13.77820  3.25180   21.68821  1.000 18.84095  ? 3   LEU A HD23 1 
ATOM   58   N  N    . LYS A 1 12  ? 14.32212  8.47739   21.87609  1.000 16.84410  ? 4   LYS A N    1 
ATOM   59   C  CA   . LYS A 1 12  ? 14.24255  9.21246   23.12798  1.000 17.77979  ? 4   LYS A CA   1 
ATOM   60   C  C    . LYS A 1 12  ? 12.89074  9.12336   23.82014  1.000 15.58248  ? 4   LYS A C    1 
ATOM   61   O  O    . LYS A 1 12  ? 12.79330  9.48424   24.99818  1.000 14.45116  ? 4   LYS A O    1 
ATOM   62   C  CB   . LYS A 1 12  ? 14.58533  10.68923  22.89176  1.000 23.68282  ? 4   LYS A CB   1 
ATOM   63   C  CG   . LYS A 1 12  ? 16.07143  10.92614  22.68478  1.000 27.35835  ? 4   LYS A CG   1 
ATOM   64   C  CD   . LYS A 1 12  ? 16.35721  12.31871  22.20017  1.000 32.22942  ? 4   LYS A CD   1 
ATOM   65   C  CE   . LYS A 1 12  ? 17.84894  12.48090  21.88354  1.000 37.03440  ? 4   LYS A CE   1 
ATOM   66   N  NZ   . LYS A 1 12  ? 18.17264  13.88357  21.45593  1.000 46.38194  ? 4   LYS A NZ   1 
ATOM   67   H  H    . LYS A 1 12  ? 13.73996  8.72134   21.29199  1.000 20.18973  ? 4   LYS A H    1 
ATOM   68   H  HA   . LYS A 1 12  ? 14.89893  8.84456   23.74013  1.000 21.31255  ? 4   LYS A HA   1 
ATOM   69   H  HB2  . LYS A 1 12  ? 14.11943  10.99780  22.09891  1.000 28.39619  ? 4   LYS A HB2  1 
ATOM   70   H  HB3  . LYS A 1 12  ? 14.30430  11.20517  23.66360  1.000 28.39619  ? 4   LYS A HB3  1 
ATOM   71   H  HG2  . LYS A 1 12  ? 16.53567  10.79737  23.52668  1.000 32.80683  ? 4   LYS A HG2  1 
ATOM   72   H  HG3  . LYS A 1 12  ? 16.40537  10.30075  22.02275  1.000 32.80683  ? 4   LYS A HG3  1 
ATOM   73   H  HD2  . LYS A 1 12  ? 15.84902  12.49267  21.39248  1.000 38.65212  ? 4   LYS A HD2  1 
ATOM   74   H  HD3  . LYS A 1 12  ? 16.11587  12.95842  22.88823  1.000 38.65212  ? 4   LYS A HD3  1 
ATOM   75   H  HE2  . LYS A 1 12  ? 18.36939  12.27603  22.67605  1.000 44.41809  ? 4   LYS A HE2  1 
ATOM   76   H  HE3  . LYS A 1 12  ? 18.09134  11.87884  21.16266  1.000 44.41809  ? 4   LYS A HE3  1 
ATOM   77   H  HZ1  . LYS A 1 12  ? 19.05487  13.99824  21.43091  1.000 55.63514  ? 4   LYS A HZ1  1 
ATOM   78   H  HZ2  . LYS A 1 12  ? 17.83799  14.03984  20.64619  1.000 55.63514  ? 4   LYS A HZ2  1 
ATOM   79   H  HZ3  . LYS A 1 12  ? 17.82191  14.46561  22.03067  1.000 55.63514  ? 4   LYS A HZ3  1 
ATOM   80   N  N    . ALA A 1 13  ? 11.85997  8.62494   23.15227  1.000 14.02583  ? 5   ALA A N    1 
ATOM   81   C  CA   . ALA A 1 13  ? 10.56800  8.46683   23.79955  1.000 14.61573  ? 5   ALA A CA   1 
ATOM   82   C  C    . ALA A 1 13  ? 9.75519   7.45901   23.00267  1.000 11.06630  ? 5   ALA A C    1 
ATOM   83   O  O    . ALA A 1 13  ? 9.84199   7.41083   21.77486  1.000 11.03919  ? 5   ALA A O    1 
ATOM   84   C  CB   . ALA A 1 13  ? 9.81750   9.80678   23.90339  1.000 18.76572  ? 5   ALA A CB   1 
ATOM   85   H  H    . ALA A 1 13  ? 11.88348  8.37314   22.33029  1.000 16.80780  ? 5   ALA A H    1 
ATOM   86   H  HA   . ALA A 1 13  ? 10.69108  8.12380   24.69849  1.000 17.51568  ? 5   ALA A HA   1 
ATOM   87   H  HB1  . ALA A 1 13  ? 8.97155   9.66076   24.35500  1.000 22.49568  ? 5   ALA A HB1  1 
ATOM   88   H  HB2  . ALA A 1 13  ? 10.35850  10.43340  24.40892  1.000 22.49568  ? 5   ALA A HB2  1 
ATOM   89   H  HB3  . ALA A 1 13  ? 9.66054   10.15087  23.01016  1.000 22.49568  ? 5   ALA A HB3  1 
ATOM   90   N  N    . VAL A 1 14  ? 8.93378   6.69170   23.71315  1.000 14.81127  ? 6   VAL A N    1 
ATOM   91   C  CA   . VAL A 1 14  ? 7.99867   5.74489   23.11740  1.000 13.36131  ? 6   VAL A CA   1 
ATOM   92   C  C    . VAL A 1 14  ? 6.60128   6.13189   23.56614  1.000 11.53512  ? 6   VAL A C    1 
ATOM   93   O  O    . VAL A 1 14  ? 6.33801   6.22949   24.76961  1.000 15.70036  ? 6   VAL A O    1 
ATOM   94   C  CB   . VAL A 1 14  ? 8.30868   4.29928   23.52770  1.000 10.88578  ? 6   VAL A CB   1 
ATOM   95   C  CG1  . VAL A 1 14  ? 7.28123   3.33463   22.89095  1.000 20.41757  ? 6   VAL A CG1  1 
ATOM   96   C  CG2  . VAL A 1 14  ? 9.72836   3.92869   23.12546  1.000 16.20456  ? 6   VAL A CG2  1 
ATOM   97   H  H    . VAL A 1 14  ? 8.89952   6.70299   24.57240  1.000 17.75034  ? 6   VAL A H    1 
ATOM   98   H  HA   . VAL A 1 14  ? 8.04955   5.81095   22.15099  1.000 16.01039  ? 6   VAL A HA   1 
ATOM   99   H  HB   . VAL A 1 14  ? 8.24204   4.21642   24.49186  1.000 13.03974  ? 6   VAL A HB   1 
ATOM   100  H  HG11 . VAL A 1 14  ? 7.51418   2.42346   23.12844  1.000 24.47789  ? 6   VAL A HG11 1 
ATOM   101  H  HG12 . VAL A 1 14  ? 6.39684   3.54832   23.22726  1.000 24.47789  ? 6   VAL A HG12 1 
ATOM   102  H  HG13 . VAL A 1 14  ? 7.30323   3.44116   21.92707  1.000 24.47789  ? 6   VAL A HG13 1 
ATOM   103  H  HG21 . VAL A 1 14  ? 9.89051   3.00103   23.35797  1.000 19.42228  ? 6   VAL A HG21 1 
ATOM   104  H  HG22 . VAL A 1 14  ? 9.82787   4.05210   22.16851  1.000 19.42228  ? 6   VAL A HG22 1 
ATOM   105  H  HG23 . VAL A 1 14  ? 10.35077  4.50215   23.59943  1.000 19.42228  ? 6   VAL A HG23 1 
ATOM   106  N  N    . ILE A 1 15  ? 5.71729   6.36280   22.61562  1.000 14.43281  ? 7   ILE A N    1 
ATOM   107  C  CA   . ILE A 1 15  ? 4.33051   6.68255   22.90875  1.000 13.85998  ? 7   ILE A CA   1 
ATOM   108  C  C    . ILE A 1 15  ? 3.55554   5.37790   22.93010  1.000 17.26593  ? 7   ILE A C    1 
ATOM   109  O  O    . ILE A 1 15  ? 3.69960   4.54858   22.02401  1.000 17.93979  ? 7   ILE A O    1 
ATOM   110  C  CB   . ILE A 1 15  ? 3.74987   7.64136   21.85897  1.000 15.66249  ? 7   ILE A CB   1 
ATOM   111  C  CG1  . ILE A 1 15  ? 4.51896   8.96154   21.82435  1.000 17.63966  ? 7   ILE A CG1  1 
ATOM   112  C  CG2  . ILE A 1 15  ? 2.28394   7.90589   22.13458  1.000 16.41853  ? 7   ILE A CG2  1 
ATOM   113  C  CD1  . ILE A 1 15  ? 4.34391   9.73409   20.52676  1.000 16.70007  ? 7   ILE A CD1  1 
ATOM   114  H  H    . ILE A 1 15  ? 5.89753   6.34036   21.77502  1.000 17.29618  ? 7   ILE A H    1 
ATOM   115  H  HA   . ILE A 1 15  ? 4.26735   7.11202   23.77620  1.000 16.60879  ? 7   ILE A HA   1 
ATOM   116  H  HB   . ILE A 1 15  ? 3.84087   7.21347   20.99321  1.000 18.77179  ? 7   ILE A HB   1 
ATOM   117  H  HG12 . ILE A 1 15  ? 4.20592   9.52466   22.54948  1.000 21.14440  ? 7   ILE A HG12 1 
ATOM   118  H  HG13 . ILE A 1 15  ? 5.46462   8.77523   21.93349  1.000 21.14440  ? 7   ILE A HG13 1 
ATOM   119  H  HG21 . ILE A 1 15  ? 1.95297   8.55130   21.49053  1.000 19.67905  ? 7   ILE A HG21 1 
ATOM   120  H  HG22 . ILE A 1 15  ? 1.79195   7.07401   22.05195  1.000 19.67905  ? 7   ILE A HG22 1 
ATOM   121  H  HG23 . ILE A 1 15  ? 2.19012   8.25778   23.03361  1.000 19.67905  ? 7   ILE A HG23 1 
ATOM   122  H  HD11 . ILE A 1 15  ? 4.86521   10.55082  20.57269  1.000 20.01690  ? 7   ILE A HD11 1 
ATOM   123  H  HD12 . ILE A 1 15  ? 4.65262   9.18570   19.78861  1.000 20.01690  ? 7   ILE A HD12 1 
ATOM   124  H  HD13 . ILE A 1 15  ? 3.40479   9.94721   20.41033  1.000 20.01690  ? 7   ILE A HD13 1 
ATOM   125  N  N    . PHE A 1 16  ? 2.72156   5.20649   23.94472  1.000 15.64459  ? 8   PHE A N    1 
ATOM   126  C  CA   . PHE A 1 16  ? 1.85322   4.04897   24.06949  1.000 17.73332  ? 8   PHE A CA   1 
ATOM   127  C  C    . PHE A 1 16  ? 0.41359   4.54125   24.06875  1.000 18.65125  ? 8   PHE A C    1 
ATOM   128  O  O    . PHE A 1 16  ? 0.06199   5.43364   24.84726  1.000 17.18767  ? 8   PHE A O    1 
ATOM   129  C  CB   . PHE A 1 16  ? 2.14385   3.27039   25.35682  1.000 14.72135  ? 8   PHE A CB   1 
ATOM   130  C  CG   . PHE A 1 16  ? 3.48932   2.58749   25.38254  1.000 16.08772  ? 8   PHE A CG   1 
ATOM   131  C  CD1  . PHE A 1 16  ? 4.61902   3.27077   25.77769  1.000 16.37648  ? 8   PHE A CD1  1 
ATOM   132  C  CD2  . PHE A 1 16  ? 3.61400   1.26607   25.01153  1.000 15.79231  ? 8   PHE A CD2  1 
ATOM   133  C  CE1  . PHE A 1 16  ? 5.84026   2.66353   25.81235  1.000 15.60502  ? 8   PHE A CE1  1 
ATOM   134  C  CE2  . PHE A 1 16  ? 4.86115   0.63026   25.03732  1.000 17.90431  ? 8   PHE A CE2  1 
ATOM   135  C  CZ   . PHE A 1 16  ? 5.97100   1.33390   25.45043  1.000 18.65431  ? 8   PHE A CZ   1 
ATOM   136  H  H    . PHE A 1 16  ? 2.63905   5.76541   24.59310  1.000 18.75032  ? 8   PHE A H    1 
ATOM   137  H  HA   . PHE A 1 16  ? 1.98886   3.44644   23.32152  1.000 21.25679  ? 8   PHE A HA   1 
ATOM   138  H  HB2  . PHE A 1 16  ? 2.11372   3.88720   26.10484  1.000 17.64243  ? 8   PHE A HB2  1 
ATOM   139  H  HB3  . PHE A 1 16  ? 1.46531   2.58555   25.46399  1.000 17.64243  ? 8   PHE A HB3  1 
ATOM   140  H  HD1  . PHE A 1 16  ? 4.54744   4.16420   26.02583  1.000 19.62859  ? 8   PHE A HD1  1 
ATOM   141  H  HD2  . PHE A 1 16  ? 2.86138   0.79142   24.74102  1.000 18.92758  ? 8   PHE A HD2  1 
ATOM   142  H  HE1  . PHE A 1 16  ? 6.58897   3.14557   26.08059  1.000 18.70283  ? 8   PHE A HE1  1 
ATOM   143  H  HE2  . PHE A 1 16  ? 4.93957   -0.25935  24.77782  1.000 21.46198  ? 8   PHE A HE2  1 
ATOM   144  H  HZ   . PHE A 1 16  ? 6.80233   0.91851   25.48593  1.000 22.36199  ? 8   PHE A HZ   1 
ATOM   145  N  N    . SER A 1 17  ? -0.40698  3.97471   23.18966  1.000 18.09682  ? 9   SER A N    1 
ATOM   146  C  CA   . SER A 1 17  ? -1.84900  4.09767   23.29881  1.000 21.54877  ? 9   SER A CA   1 
ATOM   147  C  C    . SER A 1 17  ? -2.35779  3.03382   24.25974  1.000 17.16776  ? 9   SER A C    1 
ATOM   148  O  O    . SER A 1 17  ? -1.61235  2.14905   24.68467  1.000 24.22949  ? 9   SER A O    1 
ATOM   149  C  CB   . SER A 1 17  ? -2.51072  3.95762   21.92722  1.000 27.74042  ? 9   SER A CB   1 
ATOM   150  O  OG   . SER A 1 17  ? -2.18265  2.72702   21.29396  1.000 24.39773  ? 9   SER A OG   1 
ATOM   151  H  H    . SER A 1 17  ? -0.14718  3.50940   22.51469  1.000 21.69300  ? 9   SER A H    1 
ATOM   152  H  HA   . SER A 1 17  ? -2.08739  4.97419   23.63908  1.000 25.83534  ? 9   SER A HA   1 
ATOM   153  H  HB2  . SER A 1 17  ? -3.47302  4.00075   22.04133  1.000 33.26532  ? 9   SER A HB2  1 
ATOM   154  H  HB3  . SER A 1 17  ? -2.21062  4.68676   21.36225  1.000 33.26532  ? 9   SER A HB3  1 
ATOM   155  H  HG   . SER A 1 17  ? -1.35927  2.69878   21.13011  1.000 29.25409  ? 9   SER A HG   1 
ATOM   156  N  N    . ILE A 1 18  ? -3.64176  3.11226   24.59194  1.000 18.11607  ? 10  ILE A N    1 
ATOM   157  C  CA   . ILE A 1 18  ? -4.24162  2.25999   25.62370  1.000 21.07881  ? 10  ILE A CA   1 
ATOM   158  C  C    . ILE A 1 18  ? -4.99163  1.07435   25.02463  1.000 23.26878  ? 10  ILE A C    1 
ATOM   159  O  O    . ILE A 1 18  ? -4.77871  -0.06992  25.43654  1.000 15.25284  ? 10  ILE A O    1 
ATOM   160  C  CB   . ILE A 1 18  ? -5.16904  3.10311   26.52732  1.000 26.91621  ? 10  ILE A CB   1 
ATOM   161  C  CG1  . ILE A 1 18  ? -4.34550  4.13898   27.29846  1.000 26.18109  ? 10  ILE A CG1  1 
ATOM   162  C  CG2  . ILE A 1 18  ? -5.95713  2.22142   27.46662  1.000 23.91976  ? 10  ILE A CG2  1 
ATOM   163  C  CD1  . ILE A 1 18  ? -3.23205  3.55590   28.13797  1.000 24.13673  ? 10  ILE A CD1  1 
ATOM   164  H  H    . ILE A 1 18  ? -4.19822  3.65914   24.23018  1.000 21.71609  ? 10  ILE A H    1 
ATOM   165  H  HA   . ILE A 1 18  ? -3.52543  1.89908   26.16932  1.000 25.27139  ? 10  ILE A HA   1 
ATOM   166  H  HB   . ILE A 1 18  ? -5.80521  3.57200   25.96489  1.000 32.27627  ? 10  ILE A HB   1 
ATOM   167  H  HG12 . ILE A 1 18  ? -3.94291  4.74987   26.66156  1.000 31.39412  ? 10  ILE A HG12 1 
ATOM   168  H  HG13 . ILE A 1 18  ? -4.93820  4.62369   27.89399  1.000 31.39412  ? 10  ILE A HG13 1 
ATOM   169  H  HG21 . ILE A 1 18  ? -6.44278  2.78128   28.09241  1.000 28.68052  ? 10  ILE A HG21 1 
ATOM   170  H  HG22 . ILE A 1 18  ? -6.57946  1.68616   26.94979  1.000 28.68052  ? 10  ILE A HG22 1 
ATOM   171  H  HG23 . ILE A 1 18  ? -5.34355  1.64372   27.94691  1.000 28.68052  ? 10  ILE A HG23 1 
ATOM   172  H  HD11 . ILE A 1 18  ? -2.84758  4.25879   28.68481  1.000 28.94089  ? 10  ILE A HD11 1 
ATOM   173  H  HD12 . ILE A 1 18  ? -3.59612  2.85778   28.70453  1.000 28.94089  ? 10  ILE A HD12 1 
ATOM   174  H  HD13 . ILE A 1 18  ? -2.55453  3.18565   27.55079  1.000 28.94089  ? 10  ILE A HD13 1 
ATOM   175  N  N    . ALA A 1 19  ? -5.88191  1.33865   24.06070  1.000 19.49423  ? 11  ALA A N    1 
ATOM   176  C  CA   . ALA A 1 19  ? -6.81859  0.32906   23.57469  1.000 20.05763  ? 11  ALA A CA   1 
ATOM   177  C  C    . ALA A 1 19  ? -6.07758  -0.88015  23.02800  1.000 18.11159  ? 11  ALA A C    1 
ATOM   178  O  O    . ALA A 1 19  ? -5.26646  -0.75638  22.10411  1.000 17.84855  ? 11  ALA A O    1 
ATOM   179  C  CB   . ALA A 1 19  ? -7.72515  0.91423   22.49183  1.000 27.40513  ? 11  ALA A CB   1 
ATOM   180  H  H    . ALA A 1 19  ? -5.96168  2.10125   23.67123  1.000 23.36988  ? 11  ALA A H    1 
ATOM   181  H  HA   . ALA A 1 19  ? -7.37111  0.04433   24.31937  1.000 24.04597  ? 11  ALA A HA   1 
ATOM   182  H  HB1  . ALA A 1 19  ? -8.33974  0.22742   22.18939  1.000 32.86296  ? 11  ALA A HB1  1 
ATOM   183  H  HB2  . ALA A 1 19  ? -8.22037  1.66067   22.86398  1.000 32.86296  ? 11  ALA A HB2  1 
ATOM   184  H  HB3  . ALA A 1 19  ? -7.17718  1.21727   21.75102  1.000 32.86296  ? 11  ALA A HB3  1 
ATOM   185  N  N    . ASP A 1 20  ? -6.38942  -2.05278  23.58424  1.000 21.13782  ? 12  ASP A N    1 
ATOM   186  C  CA   . ASP A 1 20  ? -5.77090  -3.31919  23.19074  1.000 14.82252  ? 12  ASP A CA   1 
ATOM   187  C  C    . ASP A 1 20  ? -4.24273  -3.25953  23.23035  1.000 20.67048  ? 12  ASP A C    1 
ATOM   188  O  O    . ASP A 1 20  ? -3.56441  -4.03048  22.54133  1.000 18.46208  ? 12  ASP A O    1 
ATOM   189  C  CB   . ASP A 1 20  ? -6.25510  -3.75386  21.80645  1.000 20.18999  ? 12  ASP A CB   1 
ATOM   190  C  CG   . ASP A 1 20  ? -7.68355  -4.21646  21.81914  1.000 22.39105  ? 12  ASP A CG   1 
ATOM   191  O  OD1  . ASP A 1 20  ? -8.13352  -4.72881  22.85453  1.000 23.95218  ? 12  ASP A OD1  1 
ATOM   192  O  OD2  . ASP A 1 20  ? -8.36793  -4.04525  20.80334  1.000 24.54665  ? 12  ASP A OD2  1 
ATOM   193  H  H    . ASP A 1 20  ? -6.97301  -2.14301  24.20944  1.000 25.34219  ? 12  ASP A H    1 
ATOM   194  H  HA   . ASP A 1 20  ? -6.03968  -3.99067  23.83710  1.000 17.76383  ? 12  ASP A HA   1 
ATOM   195  H  HB2  . ASP A 1 20  ? -6.18676  -3.00313  21.19601  1.000 24.20479  ? 12  ASP A HB2  1 
ATOM   196  H  HB3  . ASP A 1 20  ? -5.70340  -4.48756  21.49306  1.000 24.20479  ? 12  ASP A HB3  1 
ATOM   197  N  N    . VAL A 1 21  ? -3.69007  -2.36639  24.05706  1.000 11.73996  ? 13  VAL A N    1 
ATOM   198  C  CA   . VAL A 1 21  ? -2.24912  -2.29604  24.28295  1.000 11.47213  ? 13  VAL A CA   1 
ATOM   199  C  C    . VAL A 1 21  ? -1.99082  -2.37525  25.78356  1.000 19.42798  ? 13  VAL A C    1 
ATOM   200  O  O    . VAL A 1 21  ? -1.42671  -3.36220  26.27950  1.000 15.27346  ? 13  VAL A O    1 
ATOM   201  C  CB   . VAL A 1 21  ? -1.66775  -1.01420  23.65912  1.000 15.75338  ? 13  VAL A CB   1 
ATOM   202  C  CG1  . VAL A 1 21  ? -0.20320  -0.88717  23.95338  1.000 12.93342  ? 13  VAL A CG1  1 
ATOM   203  C  CG2  . VAL A 1 21  ? -1.90781  -1.02312  22.15056  1.000 18.42742  ? 13  VAL A CG2  1 
ATOM   204  H  H    . VAL A 1 21  ? -4.13749  -1.78338  24.50373  1.000 14.06476  ? 13  VAL A H    1 
ATOM   205  H  HA   . VAL A 1 21  ? -1.80511  -3.05158  23.86711  1.000 13.74337  ? 13  VAL A HA   1 
ATOM   206  H  HB   . VAL A 1 21  ? -2.11303  -0.24489  24.04745  1.000 18.88086  ? 13  VAL A HB   1 
ATOM   207  H  HG11 . VAL A 1 21  ? 0.14715   -0.11358  23.48464  1.000 15.49691  ? 13  VAL A HG11 1 
ATOM   208  H  HG12 . VAL A 1 21  ? -0.08152  -0.77772  24.90947  1.000 15.49691  ? 13  VAL A HG12 1 
ATOM   209  H  HG13 . VAL A 1 21  ? 0.25026   -1.68993  23.65197  1.000 15.49691  ? 13  VAL A HG13 1 
ATOM   210  H  HG21 . VAL A 1 21  ? -1.54169  -0.21054  21.76772  1.000 22.08972  ? 13  VAL A HG21 1 
ATOM   211  H  HG22 . VAL A 1 21  ? -1.46841  -1.79740  21.76544  1.000 22.08972  ? 13  VAL A HG22 1 
ATOM   212  H  HG23 . VAL A 1 21  ? -2.86220  -1.06696  21.98291  1.000 22.08972  ? 13  VAL A HG23 1 
ATOM   213  N  N    . VAL A 1 22  ? -2.41602  -1.34996  26.51962  1.000 16.04035  ? 14  VAL A N    1 
ATOM   214  C  CA   . VAL A 1 22  ? -2.30468  -1.37443  27.97768  1.000 16.80936  ? 14  VAL A CA   1 
ATOM   215  C  C    . VAL A 1 22  ? -3.53861  -2.00227  28.62636  1.000 19.10046  ? 14  VAL A C    1 
ATOM   216  O  O    . VAL A 1 22  ? -3.43708  -2.69216  29.64725  1.000 16.60531  ? 14  VAL A O    1 
ATOM   217  C  CB   . VAL A 1 22  ? -2.05982  0.05175   28.50478  1.000 21.74347  ? 14  VAL A CB   1 
ATOM   218  C  CG1  . VAL A 1 22  ? -2.00106  0.03823   30.02396  1.000 17.34774  ? 14  VAL A CG1  1 
ATOM   219  C  CG2  . VAL A 1 22  ? -0.78486  0.63151   27.91075  1.000 22.02367  ? 14  VAL A CG2  1 
ATOM   220  H  H    . VAL A 1 22  ? -2.77016  -0.63357  26.20184  1.000 19.22523  ? 14  VAL A H    1 
ATOM   221  H  HA   . VAL A 1 22  ? -1.54008  -1.92134  28.21681  1.000 20.14804  ? 14  VAL A HA   1 
ATOM   222  H  HB   . VAL A 1 22  ? -2.79370  0.62545   28.23425  1.000 26.06898  ? 14  VAL A HB   1 
ATOM   223  H  HG11 . VAL A 1 22  ? -1.75016  0.92097   30.33816  1.000 20.79409  ? 14  VAL A HG11 1 
ATOM   224  H  HG12 . VAL A 1 22  ? -2.87449  -0.20075  30.37167  1.000 20.79409  ? 14  VAL A HG12 1 
ATOM   225  H  HG13 . VAL A 1 22  ? -1.34191  -0.61395  30.30871  1.000 20.79409  ? 14  VAL A HG13 1 
ATOM   226  H  HG21 . VAL A 1 22  ? -0.63468  1.51362   28.28522  1.000 26.40521  ? 14  VAL A HG21 1 
ATOM   227  H  HG22 . VAL A 1 22  ? -0.04110  0.04841   28.12920  1.000 26.40521  ? 14  VAL A HG22 1 
ATOM   228  H  HG23 . VAL A 1 22  ? -0.88484  0.69353   26.94791  1.000 26.40521  ? 14  VAL A HG23 1 
ATOM   229  N  N    . LEU A 1 23  ? -4.71846  -1.76388  28.05724  1.000 18.72357  ? 15  LEU A N    1 
ATOM   230  C  CA   . LEU A 1 23  ? -5.94817  -2.36194  28.53822  1.000 18.24311  ? 15  LEU A CA   1 
ATOM   231  C  C    . LEU A 1 23  ? -6.67912  -3.01767  27.35261  1.000 22.41804  ? 15  LEU A C    1 
ATOM   232  O  O    . LEU A 1 23  ? -6.82189  -2.38205  26.29137  1.000 21.94447  ? 15  LEU A O    1 
ATOM   233  C  CB   . LEU A 1 23  ? -6.84957  -1.32097  29.19948  1.000 16.67227  ? 15  LEU A CB   1 
ATOM   234  C  CG   . LEU A 1 23  ? -6.32548  -0.63833  30.46353  1.000 19.94207  ? 15  LEU A CG   1 
ATOM   235  C  CD1  . LEU A 1 23  ? -7.31433  0.43302   30.93869  1.000 18.21885  ? 15  LEU A CD1  1 
ATOM   236  C  CD2  . LEU A 1 23  ? -6.05996  -1.62328  31.55201  1.000 23.81698  ? 15  LEU A CD2  1 
ATOM   237  H  H    . LEU A 1 23  ? -4.82836  -1.24808  27.37792  1.000 22.44509  ? 15  LEU A H    1 
ATOM   238  H  HA   . LEU A 1 23  ? -5.73430  -3.04347  29.19449  1.000 21.86855  ? 15  LEU A HA   1 
ATOM   239  H  HB2  . LEU A 1 23  ? -7.01902  -0.61989  28.55087  1.000 19.98354  ? 15  LEU A HB2  1 
ATOM   240  H  HB3  . LEU A 1 23  ? -7.68126  -1.75828  29.44022  1.000 19.98354  ? 15  LEU A HB3  1 
ATOM   241  H  HG   . LEU A 1 23  ? -5.48143  -0.21008  30.25124  1.000 23.90729  ? 15  LEU A HG   1 
ATOM   242  H  HD11 . LEU A 1 23  ? -6.96557  0.85081   31.74164  1.000 21.83943  ? 15  LEU A HD11 1 
ATOM   243  H  HD12 . LEU A 1 23  ? -7.42047  1.09710   30.23967  1.000 21.83943  ? 15  LEU A HD12 1 
ATOM   244  H  HD13 . LEU A 1 23  ? -8.16790  0.01308   31.12835  1.000 21.83943  ? 15  LEU A HD13 1 
ATOM   245  H  HD21 . LEU A 1 23  ? -5.76995  -1.14657  32.34545  1.000 28.55718  ? 15  LEU A HD21 1 
ATOM   246  H  HD22 . LEU A 1 23  ? -6.87556  -2.11345  31.74023  1.000 28.55718  ? 15  LEU A HD22 1 
ATOM   247  H  HD23 . LEU A 1 23  ? -5.36574  -2.23535  31.26162  1.000 28.55718  ? 15  LEU A HD23 1 
ATOM   248  N  N    . PRO A 1 24  ? -7.11270  -4.26492  27.49572  1.000 20.99930  ? 16  PRO A N    1 
ATOM   249  C  CA   . PRO A 1 24  ? -7.91376  -4.87049  26.41386  1.000 22.09112  ? 16  PRO A CA   1 
ATOM   250  C  C    . PRO A 1 24  ? -9.27193  -4.19369  26.31007  1.000 25.56333  ? 16  PRO A C    1 
ATOM   251  O  O    . PRO A 1 24  ? -9.98905  -4.04860  27.30129  1.000 27.95977  ? 16  PRO A O    1 
ATOM   252  C  CB   . PRO A 1 24  ? -8.04174  -6.34295  26.82790  1.000 29.57992  ? 16  PRO A CB   1 
ATOM   253  C  CG   . PRO A 1 24  ? -7.76962  -6.37137  28.30211  1.000 22.59111  ? 16  PRO A CG   1 
ATOM   254  C  CD   . PRO A 1 24  ? -6.84720  -5.20157  28.60307  1.000 27.47699  ? 16  PRO A CD   1 
ATOM   255  H  HA   . PRO A 1 24  ? -7.44752  -4.81480  25.56509  1.000 26.48615  ? 16  PRO A HA   1 
ATOM   256  H  HB2  . PRO A 1 24  ? -8.93795  -6.66071  26.63623  1.000 35.47271  ? 16  PRO A HB2  1 
ATOM   257  H  HB3  . PRO A 1 24  ? -7.39044  -6.87670  26.34642  1.000 35.47271  ? 16  PRO A HB3  1 
ATOM   258  H  HG2  . PRO A 1 24  ? -8.60488  -6.27882  28.78655  1.000 27.08614  ? 16  PRO A HG2  1 
ATOM   259  H  HG3  . PRO A 1 24  ? -7.34192  -7.21012  28.53548  1.000 27.08614  ? 16  PRO A HG3  1 
ATOM   260  H  HD2  . PRO A 1 24  ? -7.06894  -4.79813  29.45686  1.000 32.94920  ? 16  PRO A HD2  1 
ATOM   261  H  HD3  . PRO A 1 24  ? -5.91934  -5.48438  28.60077  1.000 32.94920  ? 16  PRO A HD3  1 
ATOM   262  N  N    . LEU A 1 25  ? -9.61619  -3.76140  25.09952  1.000 30.12996  ? 17  LEU A N    1 
ATOM   263  C  CA   . LEU A 1 25  ? -10.87244 -3.06676  24.85081  1.000 41.86915  ? 17  LEU A CA   1 
ATOM   264  C  C    . LEU A 1 25  ? -11.83035 -3.92336  24.03533  1.000 48.78938  ? 17  LEU A C    1 
ATOM   265  O  O    . LEU A 1 25  ? -12.95328 -4.17937  24.47741  1.000 57.26650  ? 17  LEU A O    1 
ATOM   266  C  CB   . LEU A 1 25  ? -10.61998 -1.73324  24.13021  1.000 49.91239  ? 17  LEU A CB   1 
ATOM   267  C  CG   . LEU A 1 25  ? -11.84898 -1.01295  23.56745  1.000 66.30887  ? 17  LEU A CG   1 
ATOM   268  C  CD1  . LEU A 1 25  ? -12.78575 -0.57966  24.69426  1.000 58.19904  ? 17  LEU A CD1  1 
ATOM   269  C  CD2  . LEU A 1 25  ? -11.44509 0.19349   22.72580  1.000 51.59656  ? 17  LEU A CD2  1 
ATOM   270  H  H    . LEU A 1 25  ? -9.13016  -3.86100  24.39706  1.000 36.13276  ? 17  LEU A H    1 
ATOM   271  H  HA   . LEU A 1 25  ? -11.28634 -2.86769  25.70519  1.000 50.21979  ? 17  LEU A HA   1 
ATOM   272  H  HB2  . LEU A 1 25  ? -10.19872 -1.12732  24.75973  1.000 59.87168  ? 17  LEU A HB2  1 
ATOM   273  H  HB3  . LEU A 1 25  ? -10.02389 -1.90371  23.38421  1.000 59.87168  ? 17  LEU A HB3  1 
ATOM   274  H  HG   . LEU A 1 25  ? -12.32619 -1.63165  22.99266  1.000 79.54745  ? 17  LEU A HG   1 
ATOM   275  H  HD11 . LEU A 1 25  ? -13.55876 -0.13743  24.30983  1.000 69.81566  ? 17  LEU A HD11 1 
ATOM   276  H  HD12 . LEU A 1 25  ? -13.06647 -1.36422  25.19083  1.000 69.81566  ? 17  LEU A HD12 1 
ATOM   277  H  HD13 . LEU A 1 25  ? -12.31283 0.03130   25.28075  1.000 69.81566  ? 17  LEU A HD13 1 
ATOM   278  H  HD21 . LEU A 1 25  ? -12.24514 0.62055   22.38165  1.000 61.89269  ? 17  LEU A HD21 1 
ATOM   279  H  HD22 . LEU A 1 25  ? -10.95129 0.81578   23.28241  1.000 61.89269  ? 17  LEU A HD22 1 
ATOM   280  H  HD23 . LEU A 1 25  ? -10.88799 -0.10660  21.99062  1.000 61.89269  ? 17  LEU A HD23 1 
ATOM   281  N  N    . THR A 1 26  ? -11.40101 -4.38099  22.85363  1.000 51.22647  ? 18  THR A N    1 
ATOM   282  C  CA   . THR A 1 26  ? -12.29278 -5.10263  21.94760  1.000 51.21416  ? 18  THR A CA   1 
ATOM   283  C  C    . THR A 1 26  ? -13.01609 -6.24196  22.65644  1.000 47.27252  ? 18  THR A C    1 
ATOM   284  O  O    . THR A 1 26  ? -14.23274 -6.40790  22.51162  1.000 48.86959  ? 18  THR A O    1 
ATOM   285  C  CB   . THR A 1 26  ? -11.50224 -5.64516  20.75372  1.000 40.83619  ? 18  THR A CB   1 
ATOM   286  O  OG1  . THR A 1 26  ? -10.72656 -4.59181  20.17289  1.000 36.80347  ? 18  THR A OG1  1 
ATOM   287  C  CG2  . THR A 1 26  ? -12.43686 -6.21980  19.70087  1.000 37.73432  ? 18  THR A CG2  1 
ATOM   288  H  H    . THR A 1 26  ? -10.59990 -4.28601  22.55563  1.000 61.44857  ? 18  THR A H    1 
ATOM   289  H  HA   . THR A 1 26  ? -12.95980 -4.47903  21.62031  1.000 61.43380  ? 18  THR A HA   1 
ATOM   290  H  HB   . THR A 1 26  ? -10.91374 -6.35448  21.05609  1.000 48.98024  ? 18  THR A HB   1 
ATOM   291  H  HG1  . THR A 1 26  ? -9.94502  -4.60739  20.48039  1.000 44.14097  ? 18  THR A HG1  1 
ATOM   292  H  HG21 . THR A 1 26  ? -11.92335 -6.56005  18.95158  1.000 45.25799  ? 18  THR A HG21 1 
ATOM   293  H  HG22 . THR A 1 26  ? -12.95829 -6.94449  20.08013  1.000 45.25799  ? 18  THR A HG22 1 
ATOM   294  H  HG23 . THR A 1 26  ? -13.04068 -5.53097  19.38178  1.000 45.25799  ? 18  THR A HG23 1 
ATOM   295  N  N    . SER A 1 27  ? -12.28158 -7.03917  23.42745  1.000 49.81873  ? 19  SER A N    1 
ATOM   296  C  CA   . SER A 1 27  ? -12.82221 -8.22856  24.07389  1.000 51.28565  ? 19  SER A CA   1 
ATOM   297  C  C    . SER A 1 27  ? -12.59531 -8.13841  25.57609  1.000 50.25677  ? 19  SER A C    1 
ATOM   298  O  O    . SER A 1 27  ? -11.45086 -8.06492  26.03412  1.000 44.78014  ? 19  SER A O    1 
ATOM   299  C  CB   . SER A 1 27  ? -12.17557 -9.49564  23.50598  1.000 52.91791  ? 19  SER A CB   1 
ATOM   300  O  OG   . SER A 1 27  ? -12.63892 -10.66048 24.17667  1.000 62.94780  ? 19  SER A OG   1 
ATOM   301  H  H    . SER A 1 27  ? -11.44822 -6.90736  23.59396  1.000 59.75928  ? 19  SER A H    1 
ATOM   302  H  HA   . SER A 1 27  ? -13.77915 -8.26853  23.92035  1.000 61.51960  ? 19  SER A HA   1 
ATOM   303  H  HB2  . SER A 1 27  ? -12.39853 -9.56640  22.56461  1.000 63.47830  ? 19  SER A HB2  1 
ATOM   304  H  HB3  . SER A 1 27  ? -11.21380 -9.43270  23.61530  1.000 63.47830  ? 19  SER A HB3  1 
ATOM   305  H  HG   . SER A 1 27  ? -12.28440 -11.34468 23.84233  1.000 75.51417  ? 19  SER A HG   1 
ATOM   306  N  N    . ASN A 1 28  ? -13.68516 -8.16068  26.33901  1.000 61.16051  ? 20  ASN A N    1 
ATOM   307  C  CA   . ASN A 1 28  ? -13.59485 -8.20757  27.79140  1.000 67.56822  ? 20  ASN A CA   1 
ATOM   308  C  C    . ASN A 1 28  ? -13.28836 -9.60132  28.31498  1.000 59.63771  ? 20  ASN A C    1 
ATOM   309  O  O    . ASN A 1 28  ? -13.07004 -9.75466  29.52262  1.000 64.45834  ? 20  ASN A O    1 
ATOM   310  C  CB   . ASN A 1 28  ? -14.90027 -7.71116  28.41521  1.000 61.22155  ? 20  ASN A CB   1 
ATOM   311  C  CG   . ASN A 1 28  ? -15.37489 -6.40581  27.80583  1.000 77.52752  ? 20  ASN A CG   1 
ATOM   312  O  OD1  . ASN A 1 28  ? -14.72107 -5.84450  26.92443  1.000 89.86010  ? 20  ASN A OD1  1 
ATOM   313  N  ND2  . ASN A 1 28  ? -16.51474 -5.91309  28.27533  1.000 79.13988  ? 20  ASN A ND2  1 
ATOM   314  H  H    . ASN A 1 28  ? -14.49026 -8.14931  26.03686  1.000 73.36943  ? 20  ASN A H    1 
ATOM   315  H  HA   . ASN A 1 28  ? -12.88215 -7.61447  28.07632  1.000 81.05867  ? 20  ASN A HA   1 
ATOM   316  H  HB2  . ASN A 1 28  ? -15.59158 -8.37724  28.27619  1.000 73.44267  ? 20  ASN A HB2  1 
ATOM   317  H  HB3  . ASN A 1 28  ? -14.76365 -7.56800  29.36481  1.000 73.44267  ? 20  ASN A HB3  1 
ATOM   318  H  HD21 . ASN A 1 28  ? -16.94220 -6.33191  28.89297  1.000 94.94467  ? 20  ASN A HD21 1 
ATOM   319  H  HD22 . ASN A 1 28  ? -16.82568 -5.17510  27.96183  1.000 94.94467  ? 20  ASN A HD22 1 
ATOM   320  N  N    . THR A 1 29  ? -13.25516 -10.60864 27.44168  1.000 56.83260  ? 21  THR A N    1 
ATOM   321  C  CA   . THR A 1 29  ? -12.97088 -11.97436 27.86269  1.000 52.12270  ? 21  THR A CA   1 
ATOM   322  C  C    . THR A 1 29  ? -11.59299 -12.42738 27.38968  1.000 52.64124  ? 21  THR A C    1 
ATOM   323  O  O    . THR A 1 29  ? -11.45969 -13.47585 26.74955  1.000 44.46771  ? 21  THR A O    1 
ATOM   324  C  CB   . THR A 1 29  ? -14.04138 -12.92933 27.33675  1.000 52.29749  ? 21  THR A CB   1 
ATOM   325  O  OG1  . THR A 1 29  ? -14.22931 -12.70448 25.93287  1.000 46.28671  ? 21  THR A OG1  1 
ATOM   326  C  CG2  . THR A 1 29  ? -15.35113 -12.71784 28.08381  1.000 50.93908  ? 21  THR A CG2  1 
ATOM   327  H  H    . THR A 1 29  ? -13.39477 -10.52392 26.59733  1.000 68.17593  ? 21  THR A H    1 
ATOM   328  H  HA   . THR A 1 29  ? -12.97888 -12.00381 28.83221  1.000 62.52405  ? 21  THR A HA   1 
ATOM   329  H  HB   . THR A 1 29  ? -13.76528 -13.84890 27.47485  1.000 62.73380  ? 21  THR A HB   1 
ATOM   330  H  HG1  . THR A 1 29  ? -14.81342 -13.22875 25.63360  1.000 55.52086  ? 21  THR A HG1  1 
ATOM   331  H  HG21 . THR A 1 29  ? -16.02227 -13.33827 27.75895  1.000 61.10371  ? 21  THR A HG21 1 
ATOM   332  H  HG22 . THR A 1 29  ? -15.21908 -12.86569 29.03334  1.000 61.10371  ? 21  THR A HG22 1 
ATOM   333  H  HG23 . THR A 1 29  ? -15.66818 -11.81132 27.94747  1.000 61.10371  ? 21  THR A HG23 1 
ATOM   334  N  N    . GLN A 1 30  ? -10.56561 -11.63705 27.67744  1.000 46.18402  ? 22  GLN A N    1 
ATOM   335  C  CA   . GLN A 1 30  ? -9.20376  -12.12677 27.53537  1.000 41.36326  ? 22  GLN A CA   1 
ATOM   336  C  C    . GLN A 1 30  ? -8.91435  -13.12510 28.65714  1.000 46.87736  ? 22  GLN A C    1 
ATOM   337  O  O    . GLN A 1 30  ? -9.39678  -12.94093 29.78281  1.000 42.59858  ? 22  GLN A O    1 
ATOM   338  C  CB   . GLN A 1 30  ? -8.20789  -10.96658 27.59969  1.000 38.65627  ? 22  GLN A CB   1 
ATOM   339  C  CG   . GLN A 1 30  ? -8.32966  -9.96844  26.46720  1.000 28.05287  ? 22  GLN A CG   1 
ATOM   340  C  CD   . GLN A 1 30  ? -7.75161  -10.51048 25.17522  1.000 26.59595  ? 22  GLN A CD   1 
ATOM   341  O  OE1  . GLN A 1 30  ? -7.03177  -11.51887 25.17397  1.000 23.15332  ? 22  GLN A OE1  1 
ATOM   342  N  NE2  . GLN A 1 30  ? -8.06400  -9.84847  24.06459  1.000 25.42962  ? 22  GLN A NE2  1 
ATOM   343  H  H    . GLN A 1 30  ? -10.62972 -10.82487 27.95286  1.000 55.39764  ? 22  GLN A H    1 
ATOM   344  H  HA   . GLN A 1 30  ? -9.09294  -12.56777 26.67855  1.000 49.61272  ? 22  GLN A HA   1 
ATOM   345  H  HB2  . GLN A 1 30  ? -8.34788  -10.48538 28.43020  1.000 46.36434  ? 22  GLN A HB2  1 
ATOM   346  H  HB3  . GLN A 1 30  ? -7.30883  -11.32982 27.57421  1.000 46.36434  ? 22  GLN A HB3  1 
ATOM   347  H  HG2  . GLN A 1 30  ? -9.26653  -9.76511  26.31943  1.000 33.64025  ? 22  GLN A HG2  1 
ATOM   348  H  HG3  . GLN A 1 30  ? -7.84744  -9.15975  26.70038  1.000 33.64025  ? 22  GLN A HG3  1 
ATOM   349  H  HE21 . GLN A 1 30  ? -8.56874  -9.15340  24.10587  1.000 30.49235  ? 22  GLN A HE21 1 
ATOM   350  H  HE22 . GLN A 1 30  ? -7.76122  -10.11553 23.30524  1.000 30.49235  ? 22  GLN A HE22 1 
ATOM   351  N  N    . PRO A 1 31  ? -8.15854  -14.19393 28.38681  1.000 41.55590  ? 23  PRO A N    1 
ATOM   352  C  CA   . PRO A 1 31  ? -7.72875  -15.08426 29.48176  1.000 42.53754  ? 23  PRO A CA   1 
ATOM   353  C  C    . PRO A 1 31  ? -7.19373  -14.28612 30.66708  1.000 39.86301  ? 23  PRO A C    1 
ATOM   354  O  O    . PRO A 1 31  ? -6.39271  -13.35908 30.50946  1.000 42.38851  ? 23  PRO A O    1 
ATOM   355  C  CB   . PRO A 1 31  ? -6.64068  -15.95082 28.83492  1.000 30.04297  ? 23  PRO A CB   1 
ATOM   356  C  CG   . PRO A 1 31  ? -7.00380  -15.96672 27.38062  1.000 25.37002  ? 23  PRO A CG   1 
ATOM   357  C  CD   . PRO A 1 31  ? -7.68450  -14.65209 27.06554  1.000 25.93640  ? 23  PRO A CD   1 
ATOM   358  H  HA   . PRO A 1 31  ? -8.46092  -15.65059 29.77174  1.000 51.02186  ? 23  PRO A HA   1 
ATOM   359  H  HB2  . PRO A 1 31  ? -5.76828  -15.55024 28.97398  1.000 36.02838  ? 23  PRO A HB2  1 
ATOM   360  H  HB3  . PRO A 1 31  ? -6.65885  -16.84498 29.21049  1.000 36.02838  ? 23  PRO A HB3  1 
ATOM   361  H  HG2  . PRO A 1 31  ? -6.19747  -16.06457 26.85037  1.000 30.42084  ? 23  PRO A HG2  1 
ATOM   362  H  HG3  . PRO A 1 31  ? -7.60569  -16.70778 27.20900  1.000 30.42084  ? 23  PRO A HG3  1 
ATOM   363  H  HD2  . PRO A 1 31  ? -7.05522  -14.01927 26.68547  1.000 31.10049  ? 23  PRO A HD2  1 
ATOM   364  H  HD3  . PRO A 1 31  ? -8.42899  -14.78508 26.45813  1.000 31.10049  ? 23  PRO A HD3  1 
ATOM   365  N  N    . GLN A 1 32  ? -7.66592  -14.63262 31.86985  1.000 51.35046  ? 24  GLN A N    1 
ATOM   366  C  CA   . GLN A 1 32  ? -7.31445  -13.84196 33.04727  1.000 43.58837  ? 24  GLN A CA   1 
ATOM   367  C  C    . GLN A 1 32  ? -5.82110  -13.91181 33.33994  1.000 32.28837  ? 24  GLN A C    1 
ATOM   368  O  O    . GLN A 1 32  ? -5.24664  -12.95653 33.88749  1.000 30.37421  ? 24  GLN A O    1 
ATOM   369  C  CB   . GLN A 1 32  ? -8.12034  -14.31105 34.26037  1.000 58.63203  ? 24  GLN A CB   1 
ATOM   370  C  CG   . GLN A 1 32  ? -9.60437  -13.96388 34.19341  1.000 57.07077  ? 24  GLN A CG   1 
ATOM   371  C  CD   . GLN A 1 32  ? -9.85659  -12.46497 34.21357  1.000 58.77793  ? 24  GLN A CD   1 
ATOM   372  O  OE1  . GLN A 1 32  ? -8.92817  -11.66381 34.38744  1.000 58.47627  ? 24  GLN A OE1  1 
ATOM   373  N  NE2  . GLN A 1 32  ? -11.11863 -12.07653 34.03220  1.000 49.08008  ? 24  GLN A NE2  1 
ATOM   374  H  H    . GLN A 1 32  ? -8.17897  -15.30511 32.02521  1.000 61.59736  ? 24  GLN A H    1 
ATOM   375  H  HA   . GLN A 1 32  ? -7.54470  -12.91457 32.88041  1.000 52.28285  ? 24  GLN A HA   1 
ATOM   376  H  HB2  . GLN A 1 32  ? -8.04602  -15.27580 34.32842  1.000 70.33524  ? 24  GLN A HB2  1 
ATOM   377  H  HB3  . GLN A 1 32  ? -7.75542  -13.89325 35.05609  1.000 70.33524  ? 24  GLN A HB3  1 
ATOM   378  H  HG2  . GLN A 1 32  ? -9.97590  -14.31995 33.37117  1.000 68.46173  ? 24  GLN A HG2  1 
ATOM   379  H  HG3  . GLN A 1 32  ? -10.05563 -14.35471 34.95795  1.000 68.46173  ? 24  GLN A HG3  1 
ATOM   380  H  HE21 . GLN A 1 32  ? -11.73610 -12.66307 33.91264  1.000 58.87290  ? 24  GLN A HE21 1 
ATOM   381  H  HE22 . GLN A 1 32  ? -11.31545 -11.23936 34.03474  1.000 58.87290  ? 24  GLN A HE22 1 
ATOM   382  N  N    . GLU A 1 33  ? -5.16881  -15.02037 32.96984  1.000 26.43224  ? 25  GLU A N    1 
ATOM   383  C  CA   . GLU A 1 33  ? -3.72723  -15.09657 33.16950  1.000 27.16350  ? 25  GLU A CA   1 
ATOM   384  C  C    . GLU A 1 33  ? -2.99904  -14.14869 32.21968  1.000 22.13345  ? 25  GLU A C    1 
ATOM   385  O  O    . GLU A 1 33  ? -1.91019  -13.66021 32.53975  1.000 19.68502  ? 25  GLU A O    1 
ATOM   386  C  CB   . GLU A 1 33  ? -3.23527  -16.54156 33.00777  1.000 20.78316  ? 25  GLU A CB   1 
ATOM   387  C  CG   . GLU A 1 33  ? -3.12379  -17.02961 31.58295  1.000 25.21806  ? 25  GLU A CG   1 
ATOM   388  C  CD   . GLU A 1 33  ? -4.17855  -18.08565 31.22522  1.000 26.84524  ? 25  GLU A CD   1 
ATOM   389  O  OE1  . GLU A 1 33  ? -5.38995  -17.76895 31.30988  1.000 26.02936  ? 25  GLU A OE1  1 
ATOM   390  O  OE2  . GLU A 1 33  ? -3.78472  -19.23163 30.88018  1.000 34.09362  ? 25  GLU A OE2  1 
ATOM   391  H  H    . GLU A 1 33  ? -5.52884  -15.71551 32.61381  1.000 31.69550  ? 25  GLU A H    1 
ATOM   392  H  HA   . GLU A 1 33  ? -3.51316  -14.83306 34.07814  1.000 32.57301  ? 25  GLU A HA   1 
ATOM   393  H  HB2  . GLU A 1 33  ? -2.35419  -16.61117 33.40746  1.000 24.91661  ? 25  GLU A HB2  1 
ATOM   394  H  HB3  . GLU A 1 33  ? -3.85541  -17.12899 33.46737  1.000 24.91661  ? 25  GLU A HB3  1 
ATOM   395  H  HG2  . GLU A 1 33  ? -3.23912  -16.27680 30.98221  1.000 30.23848  ? 25  GLU A HG2  1 
ATOM   396  H  HG3  . GLU A 1 33  ? -2.24811  -17.42625 31.45347  1.000 30.23848  ? 25  GLU A HG3  1 
ATOM   397  N  N    . LEU A 1 34  ? -3.59068  -13.86310 31.05808  1.000 26.09362  ? 26  LEU A N    1 
ATOM   398  C  CA   . LEU A 1 34  ? -2.90624  -13.04737 30.05822  1.000 22.93399  ? 26  LEU A CA   1 
ATOM   399  C  C    . LEU A 1 34  ? -2.72925  -11.61059 30.53145  1.000 20.92743  ? 26  LEU A C    1 
ATOM   400  O  O    . LEU A 1 34  ? -1.63210  -11.04613 30.43335  1.000 18.21007  ? 26  LEU A O    1 
ATOM   401  C  CB   . LEU A 1 34  ? -3.68308  -13.07274 28.74329  1.000 20.48708  ? 26  LEU A CB   1 
ATOM   402  C  CG   . LEU A 1 34  ? -3.09673  -12.25915 27.58733  1.000 20.66505  ? 26  LEU A CG   1 
ATOM   403  C  CD1  . LEU A 1 34  ? -1.76242  -12.86983 27.12718  1.000 22.92640  ? 26  LEU A CD1  1 
ATOM   404  C  CD2  . LEU A 1 34  ? -4.08524  -12.19959 26.44031  1.000 20.28774  ? 26  LEU A CD2  1 
ATOM   405  H  H    . LEU A 1 34  ? -4.37663  -14.12601 30.82840  1.000 31.28915  ? 26  LEU A H    1 
ATOM   406  H  HA   . LEU A 1 34  ? -2.02610  -13.42637 29.90785  1.000 27.49759  ? 26  LEU A HA   1 
ATOM   407  H  HB2  . LEU A 1 34  ? -3.73769  -13.99394 28.44444  1.000 24.56130  ? 26  LEU A HB2  1 
ATOM   408  H  HB3  . LEU A 1 34  ? -4.57282  -12.72583 28.91336  1.000 24.56130  ? 26  LEU A HB3  1 
ATOM   409  H  HG   . LEU A 1 34  ? -2.92269  -11.35229 27.88434  1.000 24.77488  ? 26  LEU A HG   1 
ATOM   410  H  HD11 . LEU A 1 34  ? -1.42300  -12.35783 26.37648  1.000 27.48848  ? 26  LEU A HD11 1 
ATOM   411  H  HD12 . LEU A 1 34  ? -1.13030  -12.83781 27.86224  1.000 27.48848  ? 26  LEU A HD12 1 
ATOM   412  H  HD13 . LEU A 1 34  ? -1.91197  -13.79005 26.85936  1.000 27.48848  ? 26  LEU A HD13 1 
ATOM   413  H  HD21 . LEU A 1 34  ? -3.69355  -11.69281 25.71185  1.000 24.32210  ? 26  LEU A HD21 1 
ATOM   414  H  HD22 . LEU A 1 34  ? -4.28268  -13.10265 26.14636  1.000 24.32210  ? 26  LEU A HD22 1 
ATOM   415  H  HD23 . LEU A 1 34  ? -4.89749  -11.76608 26.74561  1.000 24.32210  ? 26  LEU A HD23 1 
ATOM   416  N  N    . LYS A 1 35  ? -3.80722  -10.99911 31.03132  1.000 19.70399  ? 27  LYS A N    1 
ATOM   417  C  CA   . LYS A 1 35  ? -3.75982  -9.59082  31.40272  1.000 20.06413  ? 27  LYS A CA   1 
ATOM   418  C  C    . LYS A 1 35  ? -2.73174  -9.35833  32.49273  1.000 19.10198  ? 27  LYS A C    1 
ATOM   419  O  O    . LYS A 1 35  ? -1.98127  -8.37808  32.44872  1.000 15.52079  ? 27  LYS A O    1 
ATOM   420  C  CB   . LYS A 1 35  ? -5.14388  -9.12328  31.84806  1.000 21.75072  ? 27  LYS A CB   1 
ATOM   421  C  CG   . LYS A 1 35  ? -6.26831  -9.54292  30.89439  1.000 36.51287  ? 27  LYS A CG   1 
ATOM   422  C  CD   . LYS A 1 35  ? -7.55495  -8.74703  31.13770  1.000 46.23841  ? 27  LYS A CD   1 
ATOM   423  C  CE   . LYS A 1 35  ? -8.30628  -9.25926  32.35118  1.000 42.40463  ? 27  LYS A CE   1 
ATOM   424  N  NZ   . LYS A 1 35  ? -9.29519  -8.26333  32.82904  1.000 37.12900  ? 27  LYS A NZ   1 
ATOM   425  H  H    . LYS A 1 35  ? -4.56892  -11.37611 31.16277  1.000 23.62160  ? 27  LYS A H    1 
ATOM   426  H  HA   . LYS A 1 35  ? -3.50460  -9.06228  30.63044  1.000 24.05377  ? 27  LYS A HA   1 
ATOM   427  H  HB2  . LYS A 1 35  ? -5.33656  -9.50280  32.71969  1.000 26.07767  ? 27  LYS A HB2  1 
ATOM   428  H  HB3  . LYS A 1 35  ? -5.14479  -8.15470  31.90038  1.000 26.07767  ? 27  LYS A HB3  1 
ATOM   429  H  HG2  . LYS A 1 35  ? -5.98535  -9.38849  29.97953  1.000 43.79226  ? 27  LYS A HG2  1 
ATOM   430  H  HG3  . LYS A 1 35  ? -6.46473  -10.48357 31.02661  1.000 43.79226  ? 27  LYS A HG3  1 
ATOM   431  H  HD2  . LYS A 1 35  ? -7.33229  -7.81504  31.28840  1.000 55.46290  ? 27  LYS A HD2  1 
ATOM   432  H  HD3  . LYS A 1 35  ? -8.13420  -8.82882  30.36396  1.000 55.46290  ? 27  LYS A HD3  1 
ATOM   433  H  HE2  . LYS A 1 35  ? -8.77956  -10.07305 32.11738  1.000 50.86237  ? 27  LYS A HE2  1 
ATOM   434  H  HE3  . LYS A 1 35  ? -7.67777  -9.43548  33.06869  1.000 50.86237  ? 27  LYS A HE3  1 
ATOM   435  H  HZ1  . LYS A 1 35  ? -9.73706  -8.58579  33.53108  1.000 44.53161  ? 27  LYS A HZ1  1 
ATOM   436  H  HZ2  . LYS A 1 35  ? -8.88038  -7.51320  33.06850  1.000 44.53161  ? 27  LYS A HZ2  1 
ATOM   437  H  HZ3  . LYS A 1 35  ? -9.87721  -8.07758  32.18186  1.000 44.53161  ? 27  LYS A HZ3  1 
ATOM   438  N  N    . SER A 1 36  ? -2.64737  -10.27679 33.45311  1.000 19.70312  ? 28  SER A N    1 
ATOM   439  C  CA   . SER A 1 36  ? -1.63795  -10.14581 34.49262  1.000 20.66073  ? 28  SER A CA   1 
ATOM   440  C  C    . SER A 1 36  ? -0.24213  -10.32288 33.91939  1.000 18.47233  ? 28  SER A C    1 
ATOM   441  O  O    . SER A 1 36  ? 0.68698   -9.61430  34.32080  1.000 19.61286  ? 28  SER A O    1 
ATOM   442  C  CB   . SER A 1 36  ? -1.89051  -11.15656 35.60692  1.000 19.43135  ? 28  SER A CB   1 
ATOM   443  O  OG   . SER A 1 36  ? -1.08818  -10.86833 36.74089  1.000 22.94272  ? 28  SER A OG   1 
ATOM   444  H  H    . SER A 1 36  ? -3.15245  -10.96939 33.52232  1.000 23.62056  ? 28  SER A H    1 
ATOM   445  H  HA   . SER A 1 36  ? -1.70001  -9.25800  34.87841  1.000 24.76968  ? 28  SER A HA   1 
ATOM   446  H  HB2  . SER A 1 36  ? -2.82522  -11.11714 35.86315  1.000 23.29443  ? 28  SER A HB2  1 
ATOM   447  H  HB3  . SER A 1 36  ? -1.67241  -12.04456 35.28321  1.000 23.29443  ? 28  SER A HB3  1 
ATOM   448  H  HG   . SER A 1 36  ? -1.36869  -10.17456 37.12246  1.000 27.50807  ? 28  SER A HG   1 
ATOM   449  N  N    . ARG A 1 37  ? -0.07744  -11.25892 32.98061  1.000 19.81329  ? 29  ARG A N    1 
ATOM   450  C  CA   . ARG A 1 37  ? 1.21525   -11.44647 32.32779  1.000 18.99083  ? 29  ARG A CA   1 
ATOM   451  C  C    . ARG A 1 37  ? 1.62624   -10.20157 31.54923  1.000 21.71746  ? 29  ARG A C    1 
ATOM   452  O  O    . ARG A 1 37  ? 2.77542   -9.74585  31.63546  1.000 20.24492  ? 29  ARG A O    1 
ATOM   453  C  CB   . ARG A 1 37  ? 1.14268   -12.65813 31.40095  1.000 26.73951  ? 29  ARG A CB   1 
ATOM   454  C  CG   . ARG A 1 37  ? 2.48264   -13.30126 31.07429  1.000 40.99871  ? 29  ARG A CG   1 
ATOM   455  C  CD   . ARG A 1 37  ? 2.34352   -14.32817 29.94522  1.000 54.78090  ? 29  ARG A CD   1 
ATOM   456  N  NE   . ARG A 1 37  ? 2.60326   -13.73484 28.63097  1.000 65.63752  ? 29  ARG A NE   1 
ATOM   457  C  CZ   . ARG A 1 37  ? 2.20539   -14.25727 27.47325  1.000 57.01657  ? 29  ARG A CZ   1 
ATOM   458  N  NH1  . ARG A 1 37  ? 1.52533   -15.39477 27.45424  1.000 43.42404  ? 29  ARG A NH1  1 
ATOM   459  N  NH2  . ARG A 1 37  ? 2.49036   -13.64463 26.33071  1.000 54.55052  ? 29  ARG A NH2  1 
ATOM   460  H  H    . ARG A 1 37  ? -0.69372  -11.79280 32.70719  1.000 23.75275  ? 29  ARG A H    1 
ATOM   461  H  HA   . ARG A 1 37  ? 1.89138   -11.61139 33.00347  1.000 22.76581  ? 29  ARG A HA   1 
ATOM   462  H  HB2  . ARG A 1 37  ? 0.59094   -13.33485 31.82348  1.000 32.06422  ? 29  ARG A HB2  1 
ATOM   463  H  HB3  . ARG A 1 37  ? 0.74212   -12.37944 30.56263  1.000 32.06422  ? 29  ARG A HB3  1 
ATOM   464  H  HG2  . ARG A 1 37  ? 3.10823   -12.61659 30.79007  1.000 49.17526  ? 29  ARG A HG2  1 
ATOM   465  H  HG3  . ARG A 1 37  ? 2.82272   -13.75542 31.86104  1.000 49.17526  ? 29  ARG A HG3  1 
ATOM   466  H  HD2  . ARG A 1 37  ? 2.98118   -15.04554 30.08548  1.000 65.71390  ? 29  ARG A HD2  1 
ATOM   467  H  HD3  . ARG A 1 37  ? 1.44048   -14.68232 29.94497  1.000 65.71390  ? 29  ARG A HD3  1 
ATOM   468  H  HE   . ARG A 1 37  ? 3.04398   -12.99679 28.60582  1.000 78.74183  ? 29  ARG A HE   1 
ATOM   469  H  HH11 . ARG A 1 37  ? 1.34002   -15.79734 28.19126  1.000 52.08565  ? 29  ARG A HH11 1 
ATOM   470  H  HH12 . ARG A 1 37  ? 1.26939   -15.73026 26.70488  1.000 52.08565  ? 29  ARG A HH12 1 
ATOM   471  H  HH21 . ARG A 1 37  ? 2.93348   -12.90760 26.33687  1.000 65.43743  ? 29  ARG A HH21 1 
ATOM   472  H  HH22 . ARG A 1 37  ? 2.23187   -13.98473 25.58431  1.000 65.43743  ? 29  ARG A HH22 1 
ATOM   473  N  N    . ILE A 1 38  ? 0.69810   -9.63585  30.77349  1.000 18.95123  ? 30  ILE A N    1 
ATOM   474  C  CA   . ILE A 1 38  ? 1.01659   -8.44108  29.99618  1.000 13.80736  ? 30  ILE A CA   1 
ATOM   475  C  C    . ILE A 1 38  ? 1.37219   -7.28029  30.92051  1.000 16.85110  ? 30  ILE A C    1 
ATOM   476  O  O    . ILE A 1 38  ? 2.29513   -6.50149  30.64262  1.000 14.99334  ? 30  ILE A O    1 
ATOM   477  C  CB   . ILE A 1 38  ? -0.15378  -8.08306  29.06282  1.000 16.68074  ? 30  ILE A CB   1 
ATOM   478  C  CG1  . ILE A 1 38  ? -0.39008  -9.20025  28.05091  1.000 21.90116  ? 30  ILE A CG1  1 
ATOM   479  C  CG2  . ILE A 1 38  ? 0.12762   -6.77419  28.36302  1.000 25.21309  ? 30  ILE A CG2  1 
ATOM   480  C  CD1  . ILE A 1 38  ? 0.73861   -9.40977  27.05242  1.000 16.44876  ? 30  ILE A CD1  1 
ATOM   481  H  H    . ILE A 1 38  ? -0.10845  -9.92004  30.68225  1.000 22.71829  ? 30  ILE A H    1 
ATOM   482  H  HA   . ILE A 1 38  ? 1.79209   -8.63154  29.44552  1.000 16.54564  ? 30  ILE A HA   1 
ATOM   483  H  HB   . ILE A 1 38  ? -0.95887  -7.98445  29.59480  1.000 19.99370  ? 30  ILE A HB   1 
ATOM   484  H  HG12 . ILE A 1 38  ? -0.50938  -10.03270 28.53433  1.000 26.25820  ? 30  ILE A HG12 1 
ATOM   485  H  HG13 . ILE A 1 38  ? -1.19133  -8.99253  27.54519  1.000 26.25820  ? 30  ILE A HG13 1 
ATOM   486  H  HG21 . ILE A 1 38  ? -0.55238  -6.62461  27.68764  1.000 30.23251  ? 30  ILE A HG21 1 
ATOM   487  H  HG22 . ILE A 1 38  ? 0.10910   -6.05680  29.01563  1.000 30.23251  ? 30  ILE A HG22 1 
ATOM   488  H  HG23 . ILE A 1 38  ? 1.00262   -6.82031  27.94690  1.000 30.23251  ? 30  ILE A HG23 1 
ATOM   489  H  HD11 . ILE A 1 38  ? 0.49369   -10.12477 26.44439  1.000 19.71532  ? 30  ILE A HD11 1 
ATOM   490  H  HD12 . ILE A 1 38  ? 0.87864   -8.58768  26.55699  1.000 19.71532  ? 30  ILE A HD12 1 
ATOM   491  H  HD13 . ILE A 1 38  ? 1.54634   -9.64735  27.53412  1.000 19.71532  ? 30  ILE A HD13 1 
ATOM   492  N  N    . ASP A 1 39  ? 0.64133   -7.13595  32.02825  1.000 16.31322  ? 31  ASP A N    1 
ATOM   493  C  CA   . ASP A 1 39  ? 0.98095   -6.10298  32.99915  1.000 14.85239  ? 31  ASP A CA   1 
ATOM   494  C  C    . ASP A 1 39  ? 2.39033   -6.29762  33.52906  1.000 16.55312  ? 31  ASP A C    1 
ATOM   495  O  O    . ASP A 1 39  ? 3.14750   -5.32962  33.67885  1.000 16.59222  ? 31  ASP A O    1 
ATOM   496  C  CB   . ASP A 1 39  ? -0.03274  -6.11075  34.13522  1.000 17.50784  ? 31  ASP A CB   1 
ATOM   497  C  CG   . ASP A 1 39  ? -1.33438  -5.42357  33.74638  1.000 23.66602  ? 31  ASP A CG   1 
ATOM   498  O  OD1  . ASP A 1 39  ? -1.39579  -4.79395  32.65926  1.000 25.74056  ? 31  ASP A OD1  1 
ATOM   499  O  OD2  . ASP A 1 39  ? -2.29525  -5.50475  34.53396  1.000 25.31776  ? 31  ASP A OD2  1 
ATOM   500  H  H    . ASP A 1 39  ? -0.04230  -7.61493  32.23519  1.000 19.55267  ? 31  ASP A H    1 
ATOM   501  H  HA   . ASP A 1 39  ? 0.94153   -5.23406  32.56981  1.000 17.79968  ? 31  ASP A HA   1 
ATOM   502  H  HB2  . ASP A 1 39  ? -0.23500  -7.02851  34.37546  1.000 20.98622  ? 31  ASP A HB2  1 
ATOM   503  H  HB3  . ASP A 1 39  ? 0.34046   -5.64258  34.89840  1.000 20.98622  ? 31  ASP A HB3  1 
ATOM   504  N  N    . SER A 1 40  ? 2.76688   -7.54860  33.79826  1.000 17.80201  ? 32  SER A N    1 
ATOM   505  C  CA   . SER A 1 40  ? 4.11922   -7.82434  34.26443  1.000 19.55110  ? 32  SER A CA   1 
ATOM   506  C  C    . SER A 1 40  ? 5.14803   -7.49303  33.19365  1.000 17.51228  ? 32  SER A C    1 
ATOM   507  O  O    . SER A 1 40  ? 6.18601   -6.88626  33.48984  1.000 17.52692  ? 32  SER A O    1 
ATOM   508  C  CB   . SER A 1 40  ? 4.24168   -9.28669  34.68193  1.000 16.52754  ? 32  SER A CB   1 
ATOM   509  O  OG   . SER A 1 40  ? 5.54686   -9.56617  35.14620  1.000 17.74425  ? 32  SER A OG   1 
ATOM   510  H  H    . SER A 1 40  ? 2.26509   -8.24261  33.71984  1.000 21.33922  ? 32  SER A H    1 
ATOM   511  H  HA   . SER A 1 40  ? 4.29947   -7.27178  35.04101  1.000 23.43813  ? 32  SER A HA   1 
ATOM   512  H  HB2  . SER A 1 40  ? 3.60753   -9.46664  35.39353  1.000 19.80986  ? 32  SER A HB2  1 
ATOM   513  H  HB3  . SER A 1 40  ? 4.05055   -9.85119  33.91662  1.000 19.80986  ? 32  SER A HB3  1 
ATOM   514  H  HG   . SER A 1 40  ? 5.89714   -8.86838  35.45602  1.000 21.26991  ? 32  SER A HG   1 
ATOM   515  N  N    . GLU A 1 41  ? 4.87737   -7.88091  31.94124  1.000 15.29012  ? 33  GLU A N    1 
ATOM   516  C  CA   . GLU A 1 41  ? 5.83652   -7.63803  30.86486  1.000 17.55648  ? 33  GLU A CA   1 
ATOM   517  C  C    . GLU A 1 41  ? 5.92919   -6.15453  30.51181  1.000 19.20157  ? 33  GLU A C    1 
ATOM   518  O  O    . GLU A 1 41  ? 6.99118   -5.68278  30.07870  1.000 15.35890  ? 33  GLU A O    1 
ATOM   519  C  CB   . GLU A 1 41  ? 5.46188   -8.47307  29.63271  1.000 19.80793  ? 33  GLU A CB   1 
ATOM   520  C  CG   . GLU A 1 41  ? 5.59388   -9.97073  29.86669  1.000 19.86542  ? 33  GLU A CG   1 
ATOM   521  C  CD   . GLU A 1 41  ? 7.03543   -10.41522 29.95588  1.000 19.45477  ? 33  GLU A CD   1 
ATOM   522  O  OE1  . GLU A 1 41  ? 7.76949   -10.18846 28.97080  1.000 20.67222  ? 33  GLU A OE1  1 
ATOM   523  O  OE2  . GLU A 1 41  ? 7.42849   -11.01318 30.98554  1.000 22.50320  ? 33  GLU A OE2  1 
ATOM   524  H  H    . GLU A 1 41  ? 4.15665   -8.28003  31.69453  1.000 18.32495  ? 33  GLU A H    1 
ATOM   525  H  HA   . GLU A 1 41  ? 6.71691   -7.92151  31.15716  1.000 21.04459  ? 33  GLU A HA   1 
ATOM   526  H  HB2  . GLU A 1 41  ? 4.53994   -8.28734  29.39516  1.000 23.74633  ? 33  GLU A HB2  1 
ATOM   527  H  HB3  . GLU A 1 41  ? 6.04860   -8.23191  28.89888  1.000 23.74633  ? 33  GLU A HB3  1 
ATOM   528  H  HG2  . GLU A 1 41  ? 5.15518   -10.20161 30.70044  1.000 23.81531  ? 33  GLU A HG2  1 
ATOM   529  H  HG3  . GLU A 1 41  ? 5.17729   -10.44498 29.13019  1.000 23.81531  ? 33  GLU A HG3  1 
ATOM   530  N  N    . LEU A 1 42  ? 4.83911   -5.40536  30.68217  1.000 15.13965  ? 34  LEU A N    1 
ATOM   531  C  CA   . LEU A 1 42  ? 4.89415   -3.98362  30.39050  1.000 14.90484  ? 34  LEU A CA   1 
ATOM   532  C  C    . LEU A 1 42  ? 5.70489   -3.24027  31.44028  1.000 17.57225  ? 34  LEU A C    1 
ATOM   533  O  O    . LEU A 1 42  ? 6.35988   -2.24654  31.11309  1.000 17.62403  ? 34  LEU A O    1 
ATOM   534  C  CB   . LEU A 1 42  ? 3.48419   -3.41651  30.29315  1.000 20.72940  ? 34  LEU A CB   1 
ATOM   535  C  CG   . LEU A 1 42  ? 2.77246   -3.66483  28.96794  1.000 20.63731  ? 34  LEU A CG   1 
ATOM   536  C  CD1  . LEU A 1 42  ? 1.34717   -3.18695  29.06321  1.000 21.65228  ? 34  LEU A CD1  1 
ATOM   537  C  CD2  . LEU A 1 42  ? 3.48152   -2.97368  27.79864  1.000 16.61606  ? 34  LEU A CD2  1 
ATOM   538  H  H    . LEU A 1 42  ? 4.07703   -5.69253  30.95853  1.000 18.14439  ? 34  LEU A H    1 
ATOM   539  H  HA   . LEU A 1 42  ? 5.32265   -3.84873  29.53079  1.000 17.86262  ? 34  LEU A HA   1 
ATOM   540  H  HB2  . LEU A 1 42  ? 2.94473   -3.81823  30.99209  1.000 24.85209  ? 34  LEU A HB2  1 
ATOM   541  H  HB3  . LEU A 1 42  ? 3.53194   -2.45623  30.42150  1.000 24.85209  ? 34  LEU A HB3  1 
ATOM   542  H  HG   . LEU A 1 42  ? 2.78459   -4.61753  28.78596  1.000 24.74159  ? 34  LEU A HG   1 
ATOM   543  H  HD11 . LEU A 1 42  ? 0.90300   -3.34736  28.21594  1.000 25.95954  ? 34  LEU A HD11 1 
ATOM   544  H  HD12 . LEU A 1 42  ? 0.89702   -3.67510  29.77031  1.000 25.95954  ? 34  LEU A HD12 1 
ATOM   545  H  HD13 . LEU A 1 42  ? 1.34503   -2.23782  29.26333  1.000 25.95954  ? 34  LEU A HD13 1 
ATOM   546  H  HD21 . LEU A 1 42  ? 2.97121   -3.12268  26.98729  1.000 19.91609  ? 34  LEU A HD21 1 
ATOM   547  H  HD22 . LEU A 1 42  ? 3.54047   -2.02308  27.98245  1.000 19.91609  ? 34  LEU A HD22 1 
ATOM   548  H  HD23 . LEU A 1 42  ? 4.37131   -3.34793  27.70317  1.000 19.91609  ? 34  LEU A HD23 1 
ATOM   549  N  N    . ARG A 1 43  ? 5.68270   -3.70825  32.69807  1.000 16.25182  ? 35  ARG A N    1 
ATOM   550  C  CA   . ARG A 1 43  ? 6.53111   -3.10203  33.72186  1.000 18.96190  ? 35  ARG A CA   1 
ATOM   551  C  C    . ARG A 1 43  ? 7.99658   -3.32204  33.39561  1.000 16.96119  ? 35  ARG A C    1 
ATOM   552  O  O    . ARG A 1 43  ? 8.81587   -2.40925  33.54392  1.000 16.77365  ? 35  ARG A O    1 
ATOM   553  C  CB   . ARG A 1 43  ? 6.21189   -3.66770  35.10478  1.000 18.83624  ? 35  ARG A CB   1 
ATOM   554  C  CG   . ARG A 1 43  ? 4.97393   -3.09485  35.71911  1.000 23.04769  ? 35  ARG A CG   1 
ATOM   555  C  CD   . ARG A 1 43  ? 4.94067   -3.33457  37.23640  1.000 26.07228  ? 35  ARG A CD   1 
ATOM   556  N  NE   . ARG A 1 43  ? 4.12006   -2.33845  37.92005  1.000 26.97773  ? 35  ARG A NE   1 
ATOM   557  C  CZ   . ARG A 1 43  ? 3.71896   -2.43547  39.18396  1.000 45.34467  ? 35  ARG A CZ   1 
ATOM   558  N  NH1  . ARG A 1 43  ? 4.07567   -3.49203  39.90873  1.000 27.27176  ? 35  ARG A NH1  1 
ATOM   559  N  NH2  . ARG A 1 43  ? 2.97772   -1.46886  39.72729  1.000 34.13912  ? 35  ARG A NH2  1 
ATOM   560  H  H    . ARG A 1 43  ? 5.19513   -4.36079  32.97386  1.000 19.47899  ? 35  ARG A H    1 
ATOM   561  H  HA   . ARG A 1 43  ? 6.34841   -2.14973  33.74760  1.000 22.73109  ? 35  ARG A HA   1 
ATOM   562  H  HB2  . ARG A 1 43  ? 6.08811   -4.62673  35.02840  1.000 22.58030  ? 35  ARG A HB2  1 
ATOM   563  H  HB3  . ARG A 1 43  ? 6.95384   -3.47525  35.69924  1.000 22.58030  ? 35  ARG A HB3  1 
ATOM   564  H  HG2  . ARG A 1 43  ? 4.94864   -2.13828  35.56025  1.000 27.63404  ? 35  ARG A HG2  1 
ATOM   565  H  HG3  . ARG A 1 43  ? 4.19426   -3.51718  35.32585  1.000 27.63404  ? 35  ARG A HG3  1 
ATOM   566  H  HD2  . ARG A 1 43  ? 4.56657   -4.21164  37.41442  1.000 31.26355  ? 35  ARG A HD2  1 
ATOM   567  H  HD3  . ARG A 1 43  ? 5.84252   -3.28065  37.58948  1.000 31.26355  ? 35  ARG A HD3  1 
ATOM   568  H  HE   . ARG A 1 43  ? 3.88023   -1.64255  37.47531  1.000 32.35008  ? 35  ARG A HE   1 
ATOM   569  H  HH11 . ARG A 1 43  ? 4.56343   -4.10823  39.55945  1.000 32.70292  ? 35  ARG A HH11 1 
ATOM   570  H  HH12 . ARG A 1 43  ? 3.81858   -3.55904  40.72666  1.000 32.70292  ? 35  ARG A HH12 1 
ATOM   571  H  HH21 . ARG A 1 43  ? 2.75829   -0.78109  39.25993  1.000 40.94376  ? 35  ARG A HH21 1 
ATOM   572  H  HH22 . ARG A 1 43  ? 2.71922   -1.53337  40.54497  1.000 40.94376  ? 35  ARG A HH22 1 
ATOM   573  N  N    . LYS A 1 44  ? 8.34359   -4.52683  32.93646  1.000 16.18587  ? 36  LYS A N    1 
ATOM   574  C  CA   . LYS A 1 44  ? 9.69686   -4.77701  32.45179  1.000 16.24397  ? 36  LYS A CA   1 
ATOM   575  C  C    . LYS A 1 44  ? 10.05635  -3.83256  31.30910  1.000 14.46922  ? 36  LYS A C    1 
ATOM   576  O  O    . LYS A 1 44  ? 11.14310  -3.24540  31.28488  1.000 16.22897  ? 36  LYS A O    1 
ATOM   577  C  CB   . LYS A 1 44  ? 9.82523   -6.22944  31.99333  1.000 21.17501  ? 36  LYS A CB   1 
ATOM   578  C  CG   . LYS A 1 44  ? 9.82421   -7.26825  33.11418  1.000 26.71255  ? 36  LYS A CG   1 
ATOM   579  C  CD   . LYS A 1 44  ? 10.15622  -8.65390  32.54923  1.000 25.39561  ? 36  LYS A CD   1 
ATOM   580  C  CE   . LYS A 1 44  ? 9.94745   -9.74249  33.57165  1.000 29.10985  ? 36  LYS A CE   1 
ATOM   581  N  NZ   . LYS A 1 44  ? 10.04569  -11.09828 32.92117  1.000 53.25761  ? 36  LYS A NZ   1 
ATOM   582  H  H    . LYS A 1 44  ? 7.81897   -5.20709  32.89616  1.000 19.39985  ? 36  LYS A H    1 
ATOM   583  H  HA   . LYS A 1 44  ? 10.31943  -4.62635  33.18022  1.000 19.46957  ? 36  LYS A HA   1 
ATOM   584  H  HB2  . LYS A 1 44  ? 9.07853   -6.43305  31.40862  1.000 25.38683  ? 36  LYS A HB2  1 
ATOM   585  H  HB3  . LYS A 1 44  ? 10.66078  -6.32522  31.51002  1.000 25.38683  ? 36  LYS A HB3  1 
ATOM   586  H  HG2  . LYS A 1 44  ? 10.49306  -7.03448  33.77666  1.000 32.03187  ? 36  LYS A HG2  1 
ATOM   587  H  HG3  . LYS A 1 44  ? 8.94686   -7.30293  33.52644  1.000 32.03187  ? 36  LYS A HG3  1 
ATOM   588  H  HD2  . LYS A 1 44  ? 9.58035   -8.83625  31.79026  1.000 30.45155  ? 36  LYS A HD2  1 
ATOM   589  H  HD3  . LYS A 1 44  ? 11.08569  -8.67212  32.27237  1.000 30.45155  ? 36  LYS A HD3  1 
ATOM   590  H  HE2  . LYS A 1 44  ? 10.62888  -9.67848  34.25900  1.000 34.90863  ? 36  LYS A HE2  1 
ATOM   591  H  HE3  . LYS A 1 44  ? 9.06680   -9.65211  33.96812  1.000 34.90863  ? 36  LYS A HE3  1 
ATOM   592  H  HZ1  . LYS A 1 44  ? 10.01885  -11.73610 33.54132  1.000 63.88594  ? 36  LYS A HZ1  1 
ATOM   593  H  HZ2  . LYS A 1 44  ? 9.36727   -11.21515 32.35709  1.000 63.88594  ? 36  LYS A HZ2  1 
ATOM   594  H  HZ3  . LYS A 1 44  ? 10.81049  -11.16519 32.47094  1.000 63.88594  ? 36  LYS A HZ3  1 
ATOM   595  N  N    . LEU A 1 45  ? 9.16199   -3.68948  30.33592  1.000 19.77336  ? 37  LEU A N    1 
ATOM   596  C  CA   . LEU A 1 45  ? 9.45346   -2.82323  29.19917  1.000 19.77522  ? 37  LEU A CA   1 
ATOM   597  C  C    . LEU A 1 45  ? 9.71551   -1.39068  29.65066  1.000 18.59527  ? 37  LEU A C    1 
ATOM   598  O  O    . LEU A 1 45  ? 10.69109  -0.76176  29.21989  1.000 15.36680  ? 37  LEU A O    1 
ATOM   599  C  CB   . LEU A 1 45  ? 8.29585   -2.87235  28.20201  1.000 13.73873  ? 37  LEU A CB   1 
ATOM   600  C  CG   . LEU A 1 45  ? 8.41319   -2.00519  26.94702  1.000 12.73441  ? 37  LEU A CG   1 
ATOM   601  C  CD1  . LEU A 1 45  ? 9.67429   -2.30321  26.18245  1.000 14.82794  ? 37  LEU A CD1  1 
ATOM   602  C  CD2  . LEU A 1 45  ? 7.19278   -2.15332  26.05041  1.000 11.63098  ? 37  LEU A CD2  1 
ATOM   603  H  H    . LEU A 1 45  ? 8.39369   -4.07500  30.30968  1.000 23.70484  ? 37  LEU A H    1 
ATOM   604  H  HA   . LEU A 1 45  ? 10.25255  -3.14644  28.75432  1.000 23.70708  ? 37  LEU A HA   1 
ATOM   605  H  HB2  . LEU A 1 45  ? 8.20047   -3.78994  27.90228  1.000 16.46329  ? 37  LEU A HB2  1 
ATOM   606  H  HB3  . LEU A 1 45  ? 7.49208   -2.58949  28.66551  1.000 16.46329  ? 37  LEU A HB3  1 
ATOM   607  H  HG   . LEU A 1 45  ? 8.45729   -1.07956  27.23364  1.000 15.25810  ? 37  LEU A HG   1 
ATOM   608  H  HD11 . LEU A 1 45  ? 9.69254   -1.75970  25.37924  1.000 17.77033  ? 37  LEU A HD11 1 
ATOM   609  H  HD12 . LEU A 1 45  ? 10.43918  -2.09379  26.74100  1.000 17.77033  ? 37  LEU A HD12 1 
ATOM   610  H  HD13 . LEU A 1 45  ? 9.68524   -3.24381  25.94569  1.000 17.77033  ? 37  LEU A HD13 1 
ATOM   611  H  HD21 . LEU A 1 45  ? 7.30436   -1.58903  25.26937  1.000 13.93398  ? 37  LEU A HD21 1 
ATOM   612  H  HD22 . LEU A 1 45  ? 7.11087   -3.08104  25.77925  1.000 13.93398  ? 37  LEU A HD22 1 
ATOM   613  H  HD23 . LEU A 1 45  ? 6.40324   -1.88213  26.54435  1.000 13.93398  ? 37  LEU A HD23 1 
ATOM   614  N  N    . PHE A 1 46  ? 8.84840   -0.85235  30.51820  1.000 19.38653  ? 38  PHE A N    1 
ATOM   615  C  CA   . PHE A 1 46  ? 9.01111   0.53902   30.93190  1.000 22.14596  ? 38  PHE A CA   1 
ATOM   616  C  C    . PHE A 1 46  ? 10.28601  0.70705   31.74824  1.000 22.07770  ? 38  PHE A C    1 
ATOM   617  O  O    . PHE A 1 46  ? 10.98986  1.71933   31.61575  1.000 18.79694  ? 38  PHE A O    1 
ATOM   618  C  CB   . PHE A 1 46  ? 7.79129   1.02161   31.72956  1.000 21.75037  ? 38  PHE A CB   1 
ATOM   619  C  CG   . PHE A 1 46  ? 6.49312   0.93706   30.97544  1.000 21.89773  ? 38  PHE A CG   1 
ATOM   620  C  CD1  . PHE A 1 46  ? 6.47787   0.94751   29.59418  1.000 22.71355  ? 38  PHE A CD1  1 
ATOM   621  C  CD2  . PHE A 1 46  ? 5.28958   0.83604   31.65168  1.000 16.84465  ? 38  PHE A CD2  1 
ATOM   622  C  CE1  . PHE A 1 46  ? 5.27652   0.86075   28.89190  1.000 19.93956  ? 38  PHE A CE1  1 
ATOM   623  C  CE2  . PHE A 1 46  ? 4.10243   0.76100   30.97159  1.000 20.67598  ? 38  PHE A CE2  1 
ATOM   624  C  CZ   . PHE A 1 46  ? 4.09336   0.76334   29.57580  1.000 21.81370  ? 38  PHE A CZ   1 
ATOM   625  H  H    . PHE A 1 46  ? 8.17863   -1.26166  30.86958  1.000 23.24064  ? 38  PHE A H    1 
ATOM   626  H  HA   . PHE A 1 46  ? 9.07097   1.09413   30.13870  1.000 26.55196  ? 38  PHE A HA   1 
ATOM   627  H  HB2  . PHE A 1 46  ? 7.70531   0.47542   32.52655  1.000 26.07725  ? 38  PHE A HB2  1 
ATOM   628  H  HB3  . PHE A 1 46  ? 7.92882   1.94951   31.97652  1.000 26.07725  ? 38  PHE A HB3  1 
ATOM   629  H  HD1  . PHE A 1 46  ? 7.27916   1.01326   29.12673  1.000 27.23307  ? 38  PHE A HD1  1 
ATOM   630  H  HD2  . PHE A 1 46  ? 5.28666   0.81885   32.58151  1.000 20.19039  ? 38  PHE A HD2  1 
ATOM   631  H  HE1  . PHE A 1 46  ? 5.27832   0.86898   27.96194  1.000 23.90428  ? 38  PHE A HE1  1 
ATOM   632  H  HE2  . PHE A 1 46  ? 3.30123   0.70841   31.44085  1.000 24.78798  ? 38  PHE A HE2  1 
ATOM   633  H  HZ   . PHE A 1 46  ? 3.28926   0.69918   29.11298  1.000 26.15325  ? 38  PHE A HZ   1 
ATOM   634  N  N    . ALA A 1 47  ? 10.59564  -0.27400  32.60638  1.000 17.58688  ? 39  ALA A N    1 
ATOM   635  C  CA   . ALA A 1 47  ? 11.84028  -0.20791  33.36434  1.000 20.30094  ? 39  ALA A CA   1 
ATOM   636  C  C    . ALA A 1 47  ? 13.04323  -0.30000  32.43353  1.000 21.37723  ? 39  ALA A C    1 
ATOM   637  O  O    . ALA A 1 47  ? 14.05971  0.36632   32.65385  1.000 20.71305  ? 39  ALA A O    1 
ATOM   638  C  CB   . ALA A 1 47  ? 11.89683  -1.31288  34.42083  1.000 21.35048  ? 39  ALA A CB   1 
ATOM   639  H  H    . ALA A 1 47  ? 10.11234  -0.96836  32.76093  1.000 21.08106  ? 39  ALA A H    1 
ATOM   640  H  HA   . ALA A 1 47  ? 11.87103  0.64115   33.83236  1.000 24.33794  ? 39  ALA A HA   1 
ATOM   641  H  HB1  . ALA A 1 47  ? 12.71976  -1.22437  34.92664  1.000 25.59739  ? 39  ALA A HB1  1 
ATOM   642  H  HB2  . ALA A 1 47  ? 11.13354  -1.22330  35.01266  1.000 25.59739  ? 39  ALA A HB2  1 
ATOM   643  H  HB3  . ALA A 1 47  ? 11.87220  -2.17527  33.97746  1.000 25.59739  ? 39  ALA A HB3  1 
ATOM   644  N  N    . PHE A 1 48  ? 12.95380  -1.13661  31.39445  1.000 20.50248  ? 40  PHE A N    1 
ATOM   645  C  CA   . PHE A 1 48  ? 13.99943  -1.17688  30.37301  1.000 17.73800  ? 40  PHE A CA   1 
ATOM   646  C  C    . PHE A 1 48  ? 14.18896  0.18654   29.70681  1.000 17.56218  ? 40  PHE A C    1 
ATOM   647  O  O    . PHE A 1 48  ? 15.31859  0.67453   29.56537  1.000 19.92468  ? 40  PHE A O    1 
ATOM   648  C  CB   . PHE A 1 48  ? 13.65350  -2.24232  29.33053  1.000 22.53657  ? 40  PHE A CB   1 
ATOM   649  C  CG   . PHE A 1 48  ? 14.55397  -2.22632  28.12749  1.000 16.43632  ? 40  PHE A CG   1 
ATOM   650  C  CD1  . PHE A 1 48  ? 15.78617  -2.86880  28.15663  1.000 19.39337  ? 40  PHE A CD1  1 
ATOM   651  C  CD2  . PHE A 1 48  ? 14.17879  -1.56596  26.97269  1.000 18.28750  ? 40  PHE A CD2  1 
ATOM   652  C  CE1  . PHE A 1 48  ? 16.63279  -2.84331  27.05381  1.000 23.00127  ? 40  PHE A CE1  1 
ATOM   653  C  CE2  . PHE A 1 48  ? 15.01449  -1.55122  25.86471  1.000 16.00827  ? 40  PHE A CE2  1 
ATOM   654  C  CZ   . PHE A 1 48  ? 16.23914  -2.19296  25.90897  1.000 18.26147  ? 40  PHE A CZ   1 
ATOM   655  H  H    . PHE A 1 48  ? 12.30469  -1.68456  31.26024  1.000 24.57979  ? 40  PHE A H    1 
ATOM   656  H  HA   . PHE A 1 48  ? 14.83942  -1.41584  30.79518  1.000 21.26241  ? 40  PHE A HA   1 
ATOM   657  H  HB2  . PHE A 1 48  ? 13.72574  -3.11732  29.74290  1.000 27.02069  ? 40  PHE A HB2  1 
ATOM   658  H  HB3  . PHE A 1 48  ? 12.74555  -2.09451  29.02283  1.000 27.02069  ? 40  PHE A HB3  1 
ATOM   659  H  HD1  . PHE A 1 48  ? 16.04827  -3.32241  28.92503  1.000 23.24885  ? 40  PHE A HD1  1 
ATOM   660  H  HD2  . PHE A 1 48  ? 13.35926  -1.12772  26.93781  1.000 21.92181  ? 40  PHE A HD2  1 
ATOM   661  H  HE1  . PHE A 1 48  ? 17.46124  -3.26427  27.09081  1.000 27.57833  ? 40  PHE A HE1  1 
ATOM   662  H  HE2  . PHE A 1 48  ? 14.75047  -1.10874  25.09050  1.000 19.18673  ? 40  PHE A HE2  1 
ATOM   663  H  HZ   . PHE A 1 48  ? 16.79596  -2.18430  25.16414  1.000 21.89058  ? 40  PHE A HZ   1 
ATOM   664  N  N    . LEU A 1 49  ? 13.09273  0.81662   29.27552  1.000 16.56124  ? 41  LEU A N    1 
ATOM   665  C  CA   . LEU A 1 49  ? 13.21102  2.12510   28.63904  1.000 16.96487  ? 41  LEU A CA   1 
ATOM   666  C  C    . LEU A 1 49  ? 13.77238  3.15524   29.61089  1.000 17.07653  ? 41  LEU A C    1 
ATOM   667  O  O    . LEU A 1 49  ? 14.63650  3.96183   29.24564  1.000 17.33749  ? 41  LEU A O    1 
ATOM   668  C  CB   . LEU A 1 49  ? 11.85139  2.57183   28.09649  1.000 16.88023  ? 41  LEU A CB   1 
ATOM   669  C  CG   . LEU A 1 49  ? 11.25226  1.69151   26.99005  1.000 16.10708  ? 41  LEU A CG   1 
ATOM   670  C  CD1  . LEU A 1 49  ? 9.87001   2.17192   26.60571  1.000 15.58486  ? 41  LEU A CD1  1 
ATOM   671  C  CD2  . LEU A 1 49  ? 12.13584  1.63306   25.78129  1.000 22.37384  ? 41  LEU A CD2  1 
ATOM   672  H  H    . LEU A 1 49  ? 12.29006  0.51440   29.33863  1.000 19.85029  ? 41  LEU A H    1 
ATOM   673  H  HA   . LEU A 1 49  ? 13.82065  2.05747   27.88759  1.000 20.33465  ? 41  LEU A HA   1 
ATOM   674  H  HB2  . LEU A 1 49  ? 11.21918  2.58027   28.83211  1.000 20.23308  ? 41  LEU A HB2  1 
ATOM   675  H  HB3  . LEU A 1 49  ? 11.94887  3.46567   27.73255  1.000 20.23308  ? 41  LEU A HB3  1 
ATOM   676  H  HG   . LEU A 1 49  ? 11.17844  0.78986   27.34001  1.000 19.30530  ? 41  LEU A HG   1 
ATOM   677  H  HD11 . LEU A 1 49  ? 9.52341   1.60434   25.89958  1.000 18.67864  ? 41  LEU A HD11 1 
ATOM   678  H  HD12 . LEU A 1 49  ? 9.29150   2.12370   27.38282  1.000 18.67864  ? 41  LEU A HD12 1 
ATOM   679  H  HD13 . LEU A 1 49  ? 9.92958   3.08856   26.29405  1.000 18.67864  ? 41  LEU A HD13 1 
ATOM   680  H  HD21 . LEU A 1 49  ? 11.70277  1.09629   25.09921  1.000 26.82542  ? 41  LEU A HD21 1 
ATOM   681  H  HD22 . LEU A 1 49  ? 12.27975  2.53384   25.45145  1.000 26.82542  ? 41  LEU A HD22 1 
ATOM   682  H  HD23 . LEU A 1 49  ? 12.98365  1.23209   26.02894  1.000 26.82542  ? 41  LEU A HD23 1 
ATOM   683  N  N    . SER A 1 50  ? 13.28437  3.15258   30.85192  1.000 15.54517  ? 42  SER A N    1 
ATOM   684  C  CA   . SER A 1 50  ? 13.87840  4.00296   31.87358  1.000 20.56839  ? 42  SER A CA   1 
ATOM   685  C  C    . SER A 1 50  ? 15.36733  3.72302   32.01451  1.000 22.21783  ? 42  SER A C    1 
ATOM   686  O  O    . SER A 1 50  ? 16.16912  4.65550   32.15924  1.000 17.37720  ? 42  SER A O    1 
ATOM   687  C  CB   . SER A 1 50  ? 13.16762  3.78485   33.20568  1.000 21.90523  ? 42  SER A CB   1 
ATOM   688  O  OG   . SER A 1 50  ? 13.73732  4.59524   34.21164  1.000 32.09388  ? 42  SER A OG   1 
ATOM   689  H  H    . SER A 1 50  ? 12.62161  2.67516   31.12103  1.000 18.63102  ? 42  SER A H    1 
ATOM   690  H  HA   . SER A 1 50  ? 13.76608  4.93206   31.61850  1.000 24.65887  ? 42  SER A HA   1 
ATOM   691  H  HB2  . SER A 1 50  ? 12.23068  4.01538   33.10615  1.000 26.26308  ? 42  SER A HB2  1 
ATOM   692  H  HB3  . SER A 1 50  ? 13.25467  2.85346   33.46228  1.000 26.26308  ? 42  SER A HB3  1 
ATOM   693  H  HG   . SER A 1 50  ? 13.22854  5.24145   34.38241  1.000 38.48947  ? 42  SER A HG   1 
ATOM   694  N  N    . SER A 1 51  ? 15.75639  2.43925   31.96978  1.000 16.33990  ? 43  SER A N    1 
ATOM   695  C  CA   . SER A 1 51  ? 17.16553  2.08391   32.12204  1.000 21.02412  ? 43  SER A CA   1 
ATOM   696  C  C    . SER A 1 51  ? 18.02069  2.69817   31.02229  1.000 24.65795  ? 43  SER A C    1 
ATOM   697  O  O    . SER A 1 51  ? 19.20596  2.96598   31.23493  1.000 25.87034  ? 43  SER A O    1 
ATOM   698  C  CB   . SER A 1 51  ? 17.33616  0.56109   32.13760  1.000 19.91873  ? 43  SER A CB   1 
ATOM   699  O  OG   . SER A 1 51  ? 17.55347  0.04483   30.83066  1.000 26.56860  ? 43  SER A OG   1 
ATOM   700  H  H    . SER A 1 51  ? 15.22969  1.76932   31.85412  1.000 19.58469  ? 43  SER A H    1 
ATOM   701  H  HA   . SER A 1 51  ? 17.47722  2.42590   32.97456  1.000 25.20575  ? 43  SER A HA   1 
ATOM   702  H  HB2  . SER A 1 51  ? 18.09946  0.33768   32.69291  1.000 23.87928  ? 43  SER A HB2  1 
ATOM   703  H  HB3  . SER A 1 51  ? 16.53179  0.16008   32.50240  1.000 23.87928  ? 43  SER A HB3  1 
ATOM   704  H  HG   . SER A 1 51  ? 17.62770  -0.79135  30.86073  1.000 31.85913  ? 43  SER A HG   1 
ATOM   705  N  N    . LYS A 1 52  ? 17.44818  2.92686   29.84696  1.000 27.88107  ? 44  LYS A N    1 
ATOM   706  C  CA   . LYS A 1 52  ? 18.16688  3.51249   28.72604  1.000 21.61005  ? 44  LYS A CA   1 
ATOM   707  C  C    . LYS A 1 52  ? 17.97731  5.01572   28.63144  1.000 23.80605  ? 44  LYS A C    1 
ATOM   708  O  O    . LYS A 1 52  ? 18.47494  5.61970   27.67705  1.000 27.62114  ? 44  LYS A O    1 
ATOM   709  C  CB   . LYS A 1 52  ? 17.71211  2.86580   27.40770  1.000 25.19427  ? 44  LYS A CB   1 
ATOM   710  C  CG   . LYS A 1 52  ? 17.86071  1.36917   27.37652  1.000 21.37480  ? 44  LYS A CG   1 
ATOM   711  C  CD   . LYS A 1 52  ? 19.29947  0.97240   27.60049  1.000 25.51158  ? 44  LYS A CD   1 
ATOM   712  C  CE   . LYS A 1 52  ? 19.49819  -0.52301  27.36901  1.000 20.30077  ? 44  LYS A CE   1 
ATOM   713  N  NZ   . LYS A 1 52  ? 20.86014  -0.96918  27.78318  1.000 26.66668  ? 44  LYS A NZ   1 
ATOM   714  H  H    . LYS A 1 52  ? 16.62574  2.74684   29.67148  1.000 33.43410  ? 44  LYS A H    1 
ATOM   715  H  HA   . LYS A 1 52  ? 19.11287  3.33105   28.84034  1.000 25.90887  ? 44  LYS A HA   1 
ATOM   716  H  HB2  . LYS A 1 52  ? 16.77475  3.07217   27.26746  1.000 30.20994  ? 44  LYS A HB2  1 
ATOM   717  H  HB3  . LYS A 1 52  ? 18.24408  3.23023   26.68307  1.000 30.20994  ? 44  LYS A HB3  1 
ATOM   718  H  HG2  . LYS A 1 52  ? 17.31920  0.97459   28.07793  1.000 25.62657  ? 44  LYS A HG2  1 
ATOM   719  H  HG3  . LYS A 1 52  ? 17.57919  1.03304   26.51127  1.000 25.62657  ? 44  LYS A HG3  1 
ATOM   720  H  HD2  . LYS A 1 52  ? 19.86818  1.45680   26.98177  1.000 30.59071  ? 44  LYS A HD2  1 
ATOM   721  H  HD3  . LYS A 1 52  ? 19.55268  1.17769   28.51407  1.000 30.59071  ? 44  LYS A HD3  1 
ATOM   722  H  HE2  . LYS A 1 52  ? 18.84507  -1.01719  27.88873  1.000 24.33774  ? 44  LYS A HE2  1 
ATOM   723  H  HE3  . LYS A 1 52  ? 19.38793  -0.71853  26.42534  1.000 24.33774  ? 44  LYS A HE3  1 
ATOM   724  H  HZ1  . LYS A 1 52  ? 20.95682  -1.83950  27.62410  1.000 31.97683  ? 44  LYS A HZ1  1 
ATOM   725  H  HZ2  . LYS A 1 52  ? 21.47910  -0.52157  27.32642  1.000 31.97683  ? 44  LYS A HZ2  1 
ATOM   726  H  HZ3  . LYS A 1 52  ? 20.97820  -0.81961  28.65254  1.000 31.97683  ? 44  LYS A HZ3  1 
ATOM   727  N  N    . GLY A 1 53  ? 17.26140  5.62968   29.57876  1.000 20.36586  ? 45  GLY A N    1 
ATOM   728  C  CA   . GLY A 1 53  ? 16.94946  7.04783   29.48811  1.000 22.67017  ? 45  GLY A CA   1 
ATOM   729  C  C    . GLY A 1 53  ? 15.85688  7.41435   28.50192  1.000 27.92609  ? 45  GLY A C    1 
ATOM   730  O  O    . GLY A 1 53  ? 15.70818  8.59582   28.15356  1.000 22.58561  ? 45  GLY A O    1 
ATOM   731  H  H    . GLY A 1 53  ? 16.94781  5.24357   30.28032  1.000 24.41584  ? 45  GLY A H    1 
ATOM   732  H  HA2  . GLY A 1 53  ? 16.67020  7.35842   30.36358  1.000 27.18102  ? 45  GLY A HA2  1 
ATOM   733  H  HA3  . GLY A 1 53  ? 17.75285  7.52382   29.22561  1.000 27.18102  ? 45  GLY A HA3  1 
ATOM   734  N  N    . ILE A 1 54  ? 15.07471  6.43743   28.05559  1.000 20.51627  ? 46  ILE A N    1 
ATOM   735  C  CA   . ILE A 1 54  ? 13.98640  6.65967   27.11158  1.000 18.97246  ? 46  ILE A CA   1 
ATOM   736  C  C    . ILE A 1 54  ? 12.70556  6.94923   27.88722  1.000 14.75563  ? 46  ILE A C    1 
ATOM   737  O  O    . ILE A 1 54  ? 12.36711  6.24813   28.84414  1.000 22.09831  ? 46  ILE A O    1 
ATOM   738  C  CB   . ILE A 1 54  ? 13.83183  5.44478   26.17668  1.000 19.65905  ? 46  ILE A CB   1 
ATOM   739  C  CG1  . ILE A 1 54  ? 15.12877  5.23558   25.37808  1.000 20.50026  ? 46  ILE A CG1  1 
ATOM   740  C  CG2  . ILE A 1 54  ? 12.66769  5.65885   25.22738  1.000 18.55201  ? 46  ILE A CG2  1 
ATOM   741  C  CD1  . ILE A 1 54  ? 15.16267  3.94997   24.56492  1.000 17.10543  ? 46  ILE A CD1  1 
ATOM   742  H  H    . ILE A 1 54  ? 15.15719  5.61462   28.29173  1.000 24.59633  ? 46  ILE A H    1 
ATOM   743  H  HA   . ILE A 1 54  ? 14.18184  7.43717   26.56550  1.000 22.74377  ? 46  ILE A HA   1 
ATOM   744  H  HB   . ILE A 1 54  ? 13.65715  4.65676   26.71465  1.000 23.56766  ? 46  ILE A HB   1 
ATOM   745  H  HG12 . ILE A 1 54  ? 15.23557  5.97636   24.76105  1.000 24.57713  ? 46  ILE A HG12 1 
ATOM   746  H  HG13 . ILE A 1 54  ? 15.87400  5.21050   25.99850  1.000 24.57713  ? 46  ILE A HG13 1 
ATOM   747  H  HG21 . ILE A 1 54  ? 12.60693  4.90017   24.62605  1.000 22.23923  ? 46  ILE A HG21 1 
ATOM   748  H  HG22 . ILE A 1 54  ? 11.85008  5.73839   25.74321  1.000 22.23923  ? 46  ILE A HG22 1 
ATOM   749  H  HG23 . ILE A 1 54  ? 12.81918  6.47167   24.72015  1.000 22.23923  ? 46  ILE A HG23 1 
ATOM   750  H  HD11 . ILE A 1 54  ? 16.02779  3.87211   24.13316  1.000 20.50332  ? 46  ILE A HD11 1 
ATOM   751  H  HD12 . ILE A 1 54  ? 15.02057  3.19659   25.15916  1.000 20.50332  ? 46  ILE A HD12 1 
ATOM   752  H  HD13 . ILE A 1 54  ? 14.46078  3.98072   23.89612  1.000 20.50332  ? 46  ILE A HD13 1 
ATOM   753  N  N    . LYS A 1 55  ? 11.97117  7.96963   27.45797  1.000 15.31497  ? 47  LYS A N    1 
ATOM   754  C  CA   . LYS A 1 55  ? 10.75426  8.38493   28.14131  1.000 14.50821  ? 47  LYS A CA   1 
ATOM   755  C  C    . LYS A 1 55  ? 9.56334   7.55034   27.69106  1.000 17.92376  ? 47  LYS A C    1 
ATOM   756  O  O    . LYS A 1 55  ? 9.46742   7.16785   26.52001  1.000 12.93499  ? 47  LYS A O    1 
ATOM   757  C  CB   . LYS A 1 55  ? 10.47642  9.86454   27.87645  1.000 15.62398  ? 47  LYS A CB   1 
ATOM   758  C  CG   . LYS A 1 55  ? 11.43760  10.78744  28.64874  1.000 18.44874  ? 47  LYS A CG   1 
ATOM   759  C  CD   . LYS A 1 55  ? 11.33982  12.23202  28.19440  1.000 23.50856  ? 47  LYS A CD   1 
ATOM   760  C  CE   . LYS A 1 55  ? 12.37522  13.08060  28.93859  1.000 27.40946  ? 47  LYS A CE   1 
ATOM   761  N  NZ   . LYS A 1 55  ? 11.97971  14.50699  29.00938  1.000 34.40386  ? 47  LYS A NZ   1 
ATOM   762  H  H    . LYS A 1 55  ? 12.15983  8.44238   26.76478  1.000 18.35477  ? 47  LYS A H    1 
ATOM   763  H  HA   . LYS A 1 55  ? 10.86674  8.25218   29.09558  1.000 17.38667  ? 47  LYS A HA   1 
ATOM   764  H  HB2  . LYS A 1 55  ? 10.58243  10.04268  26.92886  1.000 18.72558  ? 47  LYS A HB2  1 
ATOM   765  H  HB3  . LYS A 1 55  ? 9.57029   10.07187  28.15366  1.000 18.72558  ? 47  LYS A HB3  1 
ATOM   766  H  HG2  . LYS A 1 55  ? 11.22080  10.75343  29.59359  1.000 22.11530  ? 47  LYS A HG2  1 
ATOM   767  H  HG3  . LYS A 1 55  ? 12.34917  10.48791  28.50654  1.000 22.11530  ? 47  LYS A HG3  1 
ATOM   768  H  HD2  . LYS A 1 55  ? 11.51598  12.28885  27.24222  1.000 28.18708  ? 47  LYS A HD2  1 
ATOM   769  H  HD3  . LYS A 1 55  ? 10.45474  12.57778  28.38926  1.000 28.18708  ? 47  LYS A HD3  1 
ATOM   770  H  HE2  . LYS A 1 55  ? 12.46884  12.74728  29.84470  1.000 32.86817  ? 47  LYS A HE2  1 
ATOM   771  H  HE3  . LYS A 1 55  ? 13.22554  13.02506  28.47516  1.000 32.86817  ? 47  LYS A HE3  1 
ATOM   772  H  HZ1  . LYS A 1 55  ? 12.58122  14.96681  29.47718  1.000 41.26144  ? 47  LYS A HZ1  1 
ATOM   773  H  HZ2  . LYS A 1 55  ? 11.92802  14.84958  28.18958  1.000 41.26144  ? 47  LYS A HZ2  1 
ATOM   774  H  HZ3  . LYS A 1 55  ? 11.18615  14.58356  29.40498  1.000 41.26144  ? 47  LYS A HZ3  1 
ATOM   775  N  N    . VAL A 1 56  ? 8.66803   7.27081   28.64137  1.000 18.35235  ? 48  VAL A N    1 
ATOM   776  C  CA   . VAL A 1 56  ? 7.43425   6.51871   28.41944  1.000 17.26144  ? 48  VAL A CA   1 
ATOM   777  C  C    . VAL A 1 56  ? 6.25975   7.48962   28.44328  1.000 17.93950  ? 48  VAL A C    1 
ATOM   778  O  O    . VAL A 1 56  ? 6.03632   8.18988   29.43840  1.000 13.67802  ? 48  VAL A O    1 
ATOM   779  C  CB   . VAL A 1 56  ? 7.25433   5.41766   29.47505  1.000 19.14320  ? 48  VAL A CB   1 
ATOM   780  C  CG1  . VAL A 1 56  ? 5.90600   4.75580   29.32318  1.000 18.28467  ? 48  VAL A CG1  1 
ATOM   781  C  CG2  . VAL A 1 56  ? 8.38697   4.40393   29.35257  1.000 14.04331  ? 48  VAL A CG2  1 
ATOM   782  H  H    . VAL A 1 56  ? 8.75944   7.51867   29.45979  1.000 21.99964  ? 48  VAL A H    1 
ATOM   783  H  HA   . VAL A 1 56  ? 7.46724   6.11099   27.53991  1.000 20.69054  ? 48  VAL A HA   1 
ATOM   784  H  HB   . VAL A 1 56  ? 7.28736   5.80582   30.36339  1.000 22.94866  ? 48  VAL A HB   1 
ATOM   785  H  HG11 . VAL A 1 56  ? 5.85009   4.00815   29.93865  1.000 21.91841  ? 48  VAL A HG11 1 
ATOM   786  H  HG12 . VAL A 1 56  ? 5.21206   5.40286   29.52485  1.000 21.91841  ? 48  VAL A HG12 1 
ATOM   787  H  HG13 . VAL A 1 56  ? 5.80969   4.44103   28.41074  1.000 21.91841  ? 48  VAL A HG13 1 
ATOM   788  H  HG21 . VAL A 1 56  ? 8.26546   3.71225   30.02169  1.000 16.82878  ? 48  VAL A HG21 1 
ATOM   789  H  HG22 . VAL A 1 56  ? 8.36625   4.01292   28.46511  1.000 16.82878  ? 48  VAL A HG22 1 
ATOM   790  H  HG23 . VAL A 1 56  ? 9.23288   4.85681   29.49483  1.000 16.82878  ? 48  VAL A HG23 1 
ATOM   791  N  N    . ILE A 1 57  ? 5.49638   7.51484   27.35739  1.000 14.92967  ? 49  ILE A N    1 
ATOM   792  C  CA   . ILE A 1 57  ? 4.37985   8.43311   27.19946  1.000 17.11415  ? 49  ILE A CA   1 
ATOM   793  C  C    . ILE A 1 57  ? 3.10686   7.62755   26.95649  1.000 23.87151  ? 49  ILE A C    1 
ATOM   794  O  O    . ILE A 1 57  ? 3.09947   6.69492   26.14370  1.000 18.10453  ? 49  ILE A O    1 
ATOM   795  C  CB   . ILE A 1 57  ? 4.64051   9.41329   26.04132  1.000 20.42166  ? 49  ILE A CB   1 
ATOM   796  C  CG1  . ILE A 1 57  ? 5.94746   10.18031  26.27047  1.000 22.27782  ? 49  ILE A CG1  1 
ATOM   797  C  CG2  . ILE A 1 57  ? 3.47859   10.35653  25.88748  1.000 19.56149  ? 49  ILE A CG2  1 
ATOM   798  C  CD1  . ILE A 1 57  ? 6.58712   10.68865  25.00592  1.000 24.71265  ? 49  ILE A CD1  1 
ATOM   799  H  H    . ILE A 1 57  ? 5.61031   6.99495   26.68187  1.000 17.89242  ? 49  ILE A H    1 
ATOM   800  H  HA   . ILE A 1 57  ? 4.25475   8.93656   28.01909  1.000 20.51380  ? 49  ILE A HA   1 
ATOM   801  H  HB   . ILE A 1 57  ? 4.73257   8.90559   25.21994  1.000 24.48280  ? 49  ILE A HB   1 
ATOM   802  H  HG12 . ILE A 1 57  ? 5.76370   10.94601  26.83689  1.000 26.71020  ? 49  ILE A HG12 1 
ATOM   803  H  HG13 . ILE A 1 57  ? 6.58233   9.59023   26.70596  1.000 26.71020  ? 49  ILE A HG13 1 
ATOM   804  H  HG21 . ILE A 1 57  ? 3.68504   11.00125  25.19278  1.000 23.45060  ? 49  ILE A HG21 1 
ATOM   805  H  HG22 . ILE A 1 57  ? 2.68941   9.84824   25.64309  1.000 23.45060  ? 49  ILE A HG22 1 
ATOM   806  H  HG23 . ILE A 1 57  ? 3.32962   10.81410  26.72971  1.000 23.45060  ? 49  ILE A HG23 1 
ATOM   807  H  HD11 . ILE A 1 57  ? 7.42768   11.11880  25.22804  1.000 29.63199  ? 49  ILE A HD11 1 
ATOM   808  H  HD12 . ILE A 1 57  ? 6.74595   9.94037   24.40947  1.000 29.63199  ? 49  ILE A HD12 1 
ATOM   809  H  HD13 . ILE A 1 57  ? 5.99027   11.32667  24.58450  1.000 29.63199  ? 49  ILE A HD13 1 
ATOM   810  N  N    . PHE A 1 58  ? 2.02953   8.01202   27.63494  1.000 17.20746  ? 50  PHE A N    1 
ATOM   811  C  CA   . PHE A 1 58  ? 0.68897   7.51162   27.36356  1.000 18.11771  ? 50  PHE A CA   1 
ATOM   812  C  C    . PHE A 1 58  ? -0.06912  8.65079   26.69444  1.000 14.37789  ? 50  PHE A C    1 
ATOM   813  O  O    . PHE A 1 58  ? -0.12686  9.74898   27.24320  1.000 17.91666  ? 50  PHE A O    1 
ATOM   814  C  CB   . PHE A 1 58  ? -0.02081  7.06114   28.65023  1.000 17.11271  ? 50  PHE A CB   1 
ATOM   815  C  CG   . PHE A 1 58  ? 0.67840   5.93738   29.37408  1.000 13.29957  ? 50  PHE A CG   1 
ATOM   816  C  CD1  . PHE A 1 58  ? 0.90571   4.72283   28.74732  1.000 17.17667  ? 50  PHE A CD1  1 
ATOM   817  C  CD2  . PHE A 1 58  ? 1.09283   6.09505   30.68532  1.000 14.13143  ? 50  PHE A CD2  1 
ATOM   818  C  CE1  . PHE A 1 58  ? 1.54949   3.69233   29.42122  1.000 19.48636  ? 50  PHE A CE1  1 
ATOM   819  C  CE2  . PHE A 1 58  ? 1.75473   5.08207   31.35369  1.000 17.59569  ? 50  PHE A CE2  1 
ATOM   820  C  CZ   . PHE A 1 58  ? 1.96719   3.87398   30.72700  1.000 16.06711  ? 50  PHE A CZ   1 
ATOM   821  H  H    . PHE A 1 58  ? 2.05285   8.58158   28.27888  1.000 20.62576  ? 50  PHE A H    1 
ATOM   822  H  HA   . PHE A 1 58  ? 0.72290   6.74118   26.77519  1.000 21.71807  ? 50  PHE A HA   1 
ATOM   823  H  HB2  . PHE A 1 58  ? -0.07312  7.81591   29.25726  1.000 20.51206  ? 50  PHE A HB2  1 
ATOM   824  H  HB3  . PHE A 1 58  ? -0.91299  6.75584   28.42282  1.000 20.51206  ? 50  PHE A HB3  1 
ATOM   825  H  HD1  . PHE A 1 58  ? 0.62548   4.59648   27.86959  1.000 20.58881  ? 50  PHE A HD1  1 
ATOM   826  H  HD2  . PHE A 1 58  ? 0.92292   6.89696   31.12460  1.000 16.93453  ? 50  PHE A HD2  1 
ATOM   827  H  HE1  . PHE A 1 58  ? 1.69957   2.88002   28.99398  1.000 23.36044  ? 50  PHE A HE1  1 
ATOM   828  H  HE2  . PHE A 1 58  ? 2.05556   5.21578   32.22347  1.000 21.09164  ? 50  PHE A HE2  1 
ATOM   829  H  HZ   . PHE A 1 58  ? 2.39076   3.18172   31.18118  1.000 19.25734  ? 50  PHE A HZ   1 
ATOM   830  N  N    . LEU A 1 59  ? -0.64340  8.39379   25.52257  1.000 16.07858  ? 51  LEU A N    1 
ATOM   831  C  CA   . LEU A 1 59  ? -1.41578  9.37514   24.76336  1.000 16.42291  ? 51  LEU A CA   1 
ATOM   832  C  C    . LEU A 1 59  ? -2.85413  8.88408   24.67919  1.000 18.97186  ? 51  LEU A C    1 
ATOM   833  O  O    . LEU A 1 59  ? -3.12427  7.83997   24.07003  1.000 18.83785  ? 51  LEU A O    1 
ATOM   834  C  CB   . LEU A 1 59  ? -0.83382  9.56574   23.36025  1.000 18.89538  ? 51  LEU A CB   1 
ATOM   835  C  CG   . LEU A 1 59  ? -1.62302  10.51113  22.44418  1.000 18.12093  ? 51  LEU A CG   1 
ATOM   836  C  CD1  . LEU A 1 59  ? -1.65617  11.92537  23.01092  1.000 19.33139  ? 51  LEU A CD1  1 
ATOM   837  C  CD2  . LEU A 1 59  ? -1.03390  10.53648  21.04141  1.000 19.50822  ? 51  LEU A CD2  1 
ATOM   838  H  H    . LEU A 1 59  ? -0.59815  7.62909   25.13169  1.000 19.27111  ? 51  LEU A H    1 
ATOM   839  H  HA   . LEU A 1 59  ? -1.39847  10.23150  25.21861  1.000 19.68431  ? 51  LEU A HA   1 
ATOM   840  H  HB2  . LEU A 1 59  ? 0.06176   9.92782   23.44819  1.000 22.65127  ? 51  LEU A HB2  1 
ATOM   841  H  HB3  . LEU A 1 59  ? -0.80032  8.70010   22.92386  1.000 22.65127  ? 51  LEU A HB3  1 
ATOM   842  H  HG   . LEU A 1 59  ? -2.53294  10.17952  22.38973  1.000 21.72192  ? 51  LEU A HG   1 
ATOM   843  H  HD11 . LEU A 1 59  ? -2.16228  12.49452  22.41024  1.000 23.17447  ? 51  LEU A HD11 1 
ATOM   844  H  HD12 . LEU A 1 59  ? -2.07949  11.90608  23.88347  1.000 23.17447  ? 51  LEU A HD12 1 
ATOM   845  H  HD13 . LEU A 1 59  ? -0.74735  12.25472  23.09140  1.000 23.17447  ? 51  LEU A HD13 1 
ATOM   846  H  HD21 . LEU A 1 59  ? -1.56669  11.12662  20.48575  1.000 23.38667  ? 51  LEU A HD21 1 
ATOM   847  H  HD22 . LEU A 1 59  ? -0.12098  10.86096  21.08811  1.000 23.38667  ? 51  LEU A HD22 1 
ATOM   848  H  HD23 . LEU A 1 59  ? -1.04724  9.63763   20.67700  1.000 23.38667  ? 51  LEU A HD23 1 
ATOM   849  N  N    . THR A 1 60  ? -3.77203  9.63429   25.28105  1.000 17.61171  ? 52  THR A N    1 
ATOM   850  C  CA   . THR A 1 60  ? -5.15156  9.19899   25.42110  1.000 18.51958  ? 52  THR A CA   1 
ATOM   851  C  C    . THR A 1 60  ? -6.08313  10.35917  25.12651  1.000 20.23304  ? 52  THR A C    1 
ATOM   852  O  O    . THR A 1 60  ? -5.70817  11.52550  25.25562  1.000 15.29499  ? 52  THR A O    1 
ATOM   853  C  CB   . THR A 1 60  ? -5.43706  8.67137   26.83615  1.000 17.37772  ? 52  THR A CB   1 
ATOM   854  O  OG1  . THR A 1 60  ? -5.31418  9.73610   27.79208  1.000 19.97793  ? 52  THR A OG1  1 
ATOM   855  C  CG2  . THR A 1 60  ? -4.45511  7.58851   27.21775  1.000 14.92605  ? 52  THR A CG2  1 
ATOM   856  H  H    . THR A 1 60  ? -3.61545  10.40903  25.61998  1.000 21.11086  ? 52  THR A H    1 
ATOM   857  H  HA   . THR A 1 60  ? -5.32224  8.49275   24.77845  1.000 22.20030  ? 52  THR A HA   1 
ATOM   858  H  HB   . THR A 1 60  ? -6.33599  8.30726   26.85209  1.000 20.83008  ? 52  THR A HB   1 
ATOM   859  H  HG1  . THR A 1 60  ? -4.54749  9.72712   28.13516  1.000 23.95032  ? 52  THR A HG1  1 
ATOM   860  H  HG21 . THR A 1 60  ? -4.61220  7.30544   28.13213  1.000 17.88807  ? 52  THR A HG21 1 
ATOM   861  H  HG22 . THR A 1 60  ? -4.55879  6.82431   26.62941  1.000 17.88807  ? 52  THR A HG22 1 
ATOM   862  H  HG23 . THR A 1 60  ? -3.54746  7.92242   27.14310  1.000 17.88807  ? 52  THR A HG23 1 
ATOM   863  N  N    . ASN A 1 61  ? -7.31434  10.01757  24.74425  1.000 17.13786  ? 53  ASN A N    1 
ATOM   864  C  CA   A ASN A 1 61  ? -8.36122  11.00031  24.49311  0.536 21.81130  ? 53  ASN A CA   1 
ATOM   865  C  CA   B ASN A 1 61  ? -8.35229  11.01034  24.49677  0.464 25.43881  ? 53  ASN A CA   1 
ATOM   866  C  C    . ASN A 1 61  ? -9.15839  11.30077  25.75860  1.000 23.08200  ? 53  ASN A C    1 
ATOM   867  O  O    . ASN A 1 61  ? -9.29586  12.46546  26.15541  1.000 23.95659  ? 53  ASN A O    1 
ATOM   868  C  CB   A ASN A 1 61  ? -9.31473  10.49554  23.40188  0.536 27.92582  ? 53  ASN A CB   1 
ATOM   869  C  CB   B ASN A 1 61  ? -9.27885  10.52902  23.37158  0.464 27.85784  ? 53  ASN A CB   1 
ATOM   870  C  CG   A ASN A 1 61  ? -8.74887  10.63597  22.00624  0.536 19.44087  ? 53  ASN A CG   1 
ATOM   871  C  CG   B ASN A 1 61  ? -10.22725 11.61490  22.88152  0.464 25.82456  ? 53  ASN A CG   1 
ATOM   872  O  OD1  A ASN A 1 61  ? -7.80697  11.37917  21.77500  0.536 23.26489  ? 53  ASN A OD1  1 
ATOM   873  O  OD1  B ASN A 1 61  ? -9.84338  12.77368  22.74884  0.464 26.12499  ? 53  ASN A OD1  1 
ATOM   874  N  ND2  A ASN A 1 61  ? -9.32573  9.90890   21.06721  0.536 21.90787  ? 53  ASN A ND2  1 
ATOM   875  N  ND2  B ASN A 1 61  ? -11.47503 11.23888  22.61185  0.464 26.44008  ? 53  ASN A ND2  1 
ATOM   876  H  H    A ASN A 1 61  ? -7.57080  9.20590   24.62165  0.536 20.54224  ? 53  ASN A H    1 
ATOM   877  H  H    B ASN A 1 61  ? -7.57367  9.20697   24.62061  0.464 20.54224  ? 53  ASN A H    1 
ATOM   878  H  HA   A ASN A 1 61  ? -7.94574  11.81877  24.17944  0.536 26.15037  ? 53  ASN A HA   1 
ATOM   879  H  HA   B ASN A 1 61  ? -7.93716  11.83746  24.20619  0.464 30.50338  ? 53  ASN A HA   1 
ATOM   880  H  HB2  A ASN A 1 61  ? -9.49950  9.55580   23.55564  0.536 33.48780  ? 53  ASN A HB2  1 
ATOM   881  H  HB2  B ASN A 1 61  ? -8.73864  10.24117  22.61911  0.464 33.40621  ? 53  ASN A HB2  1 
ATOM   882  H  HB3  A ASN A 1 61  ? -10.13819 11.00657  23.44266  0.536 33.48780  ? 53  ASN A HB3  1 
ATOM   883  H  HB3  B ASN A 1 61  ? -9.81405  9.78888   23.69815  0.464 33.40621  ? 53  ASN A HB3  1 
ATOM   884  H  HD21 A ASN A 1 61  ? -9.04283  9.95109   20.25617  0.536 26.26626  ? 53  ASN A HD21 1 
ATOM   885  H  HD21 B ASN A 1 61  ? -12.04734 11.81669  22.33222  0.464 31.70491  ? 53  ASN A HD21 1 
ATOM   886  H  HD22 A ASN A 1 61  ? -9.98437  9.39311   21.26660  0.536 26.26626  ? 53  ASN A HD22 1 
ATOM   887  H  HD22 B ASN A 1 61  ? -11.70906 10.41807  22.71720  0.464 31.70491  ? 53  ASN A HD22 1 
ATOM   888  N  N    . LYS A 1 62  ? -9.68045  10.25515  26.39814  1.000 23.47031  ? 54  LYS A N    1 
ATOM   889  C  CA   . LYS A 1 62  ? -10.56611 10.37665  27.54637  1.000 33.10875  ? 54  LYS A CA   1 
ATOM   890  C  C    . LYS A 1 62  ? -9.90409  9.84848   28.81147  1.000 28.00777  ? 54  LYS A C    1 
ATOM   891  O  O    . LYS A 1 62  ? -9.18652  8.83980   28.78136  1.000 24.52270  ? 54  LYS A O    1 
ATOM   892  C  CB   . LYS A 1 62  ? -11.87306 9.60751   27.31097  1.000 29.28872  ? 54  LYS A CB   1 
ATOM   893  C  CG   . LYS A 1 62  ? -12.63071 10.01905  26.06999  1.000 28.48489  ? 54  LYS A CG   1 
ATOM   894  C  CD   . LYS A 1 62  ? -13.16056 11.42729  26.22164  1.000 29.67255  ? 54  LYS A CD   1 
ATOM   895  C  CE   . LYS A 1 62  ? -14.27063 11.70377  25.23178  1.000 32.41242  ? 54  LYS A CE   1 
ATOM   896  N  NZ   . LYS A 1 62  ? -15.00845 12.96389  25.58118  1.000 42.66361  ? 54  LYS A NZ   1 
ATOM   897  H  H    . LYS A 1 62  ? -9.52874  9.43861   26.17488  1.000 28.14119  ? 54  LYS A H    1 
ATOM   898  H  HA   . LYS A 1 62  ? -10.76317 11.31666  27.68223  1.000 39.70731  ? 54  LYS A HA   1 
ATOM   899  H  HB2  . LYS A 1 62  ? -11.66480 8.66385   27.22703  1.000 35.12327  ? 54  LYS A HB2  1 
ATOM   900  H  HB3  . LYS A 1 62  ? -12.45729 9.75193   28.07170  1.000 35.12327  ? 54  LYS A HB3  1 
ATOM   901  H  HG2  . LYS A 1 62  ? -12.03823 9.99186   25.30244  1.000 34.15868  ? 54  LYS A HG2  1 
ATOM   902  H  HG3  . LYS A 1 62  ? -13.38031 9.41911   25.93189  1.000 34.15868  ? 54  LYS A HG3  1 
ATOM   903  H  HD2  . LYS A 1 62  ? -13.51323 11.54436  27.11764  1.000 35.58387  ? 54  LYS A HD2  1 
ATOM   904  H  HD3  . LYS A 1 62  ? -12.44336 12.06058  26.06204  1.000 35.58387  ? 54  LYS A HD3  1 
ATOM   905  H  HE2  . LYS A 1 62  ? -13.89287 11.80611  24.34424  1.000 38.87171  ? 54  LYS A HE2  1 
ATOM   906  H  HE3  . LYS A 1 62  ? -14.90144 10.96695  25.24091  1.000 38.87171  ? 54  LYS A HE3  1 
ATOM   907  H  HZ1  . LYS A 1 62  ? -15.65653 13.11126  24.98925  1.000 51.17315  ? 54  LYS A HZ1  1 
ATOM   908  H  HZ2  . LYS A 1 62  ? -15.36871 12.89091  26.39173  1.000 51.17315  ? 54  LYS A HZ2  1 
ATOM   909  H  HZ3  . LYS A 1 62  ? -14.44885 13.65593  25.57507  1.000 51.17315  ? 54  LYS A HZ3  1 
ATOM   910  N  N    . ASN A 1 63  ? -10.16417 10.53603  29.92561  1.000 23.58214  ? 55  ASN A N    1 
ATOM   911  C  CA   . ASN A 1 63  ? -9.75817  10.06587  31.24674  1.000 22.21246  ? 55  ASN A CA   1 
ATOM   912  C  C    . ASN A 1 63  ? -10.77871 9.04478   31.75108  1.000 26.36961  ? 55  ASN A C    1 
ATOM   913  O  O    . ASN A 1 63  ? -11.34949 9.17537   32.83160  1.000 25.75905  ? 55  ASN A O    1 
ATOM   914  C  CB   . ASN A 1 63  ? -9.62265  11.23218  32.21542  1.000 23.96735  ? 55  ASN A CB   1 
ATOM   915  C  CG   . ASN A 1 63  ? -8.93978  10.83774  33.50214  1.000 17.11292  ? 55  ASN A CG   1 
ATOM   916  O  OD1  . ASN A 1 63  ? -8.12276  9.92251   33.53923  1.000 21.06257  ? 55  ASN A OD1  1 
ATOM   917  N  ND2  . ASN A 1 63  ? -9.26140  11.53729  34.56306  1.000 20.15941  ? 55  ASN A ND2  1 
ATOM   918  H  H    . ASN A 1 63  ? -10.58067 11.28830  29.94006  1.000 28.27538  ? 55  ASN A H    1 
ATOM   919  H  HA   . ASN A 1 63  ? -8.88824  9.64202   31.17987  1.000 26.63177  ? 55  ASN A HA   1 
ATOM   920  H  HB2  . ASN A 1 63  ? -9.09657  11.93190  31.79763  1.000 28.73763  ? 55  ASN A HB2  1 
ATOM   921  H  HB3  . ASN A 1 63  ? -10.50633 11.56717  32.43400  1.000 28.73763  ? 55  ASN A HB3  1 
ATOM   922  H  HD21 . ASN A 1 63  ? -8.90229  11.35555  35.32307  1.000 24.16810  ? 55  ASN A HD21 1 
ATOM   923  H  HD22 . ASN A 1 63  ? -9.83151  12.17797  34.49908  1.000 24.16810  ? 55  ASN A HD22 1 
ATOM   924  N  N    . ARG A 1 64  ? -11.00731 8.01984   30.92856  1.000 24.17983  ? 56  ARG A N    1 
ATOM   925  C  CA   . ARG A 1 64  ? -12.06239 7.05166   31.19743  1.000 31.08678  ? 56  ARG A CA   1 
ATOM   926  C  C    . ARG A 1 64  ? -11.82509 6.34404   32.53029  1.000 29.75441  ? 56  ARG A C    1 
ATOM   927  O  O    . ARG A 1 64  ? -10.72085 6.33269   33.07313  1.000 34.12030  ? 56  ARG A O    1 
ATOM   928  C  CB   . ARG A 1 64  ? -12.14873 6.03012   30.05873  1.000 34.13537  ? 56  ARG A CB   1 
ATOM   929  C  CG   . ARG A 1 64  ? -11.26581 4.78676   30.24046  1.000 43.57335  ? 56  ARG A CG   1 
ATOM   930  C  CD   . ARG A 1 64  ? -10.62710 4.37711   28.91318  1.000 47.63543  ? 56  ARG A CD   1 
ATOM   931  N  NE   . ARG A 1 64  ? -10.43784 2.93002   28.79014  1.000 54.49293  ? 56  ARG A NE   1 
ATOM   932  C  CZ   . ARG A 1 64  ? -9.82861  2.33766   27.76333  1.000 75.64801  ? 56  ARG A CZ   1 
ATOM   933  N  NH1  . ARG A 1 64  ? -9.70518  1.01067   27.73524  1.000 62.60503  ? 56  ARG A NH1  1 
ATOM   934  N  NH2  . ARG A 1 64  ? -9.34204  3.07048   26.76136  1.000 54.44496  ? 56  ARG A NH2  1 
ATOM   935  H  H    . ARG A 1 64  ? -10.56374 7.86486   30.20827  1.000 28.99261  ? 56  ARG A H    1 
ATOM   936  H  HA   . ARG A 1 64  ? -12.91460 7.51129   31.25559  1.000 37.28095  ? 56  ARG A HA   1 
ATOM   937  H  HB2  . ARG A 1 64  ? -13.06740 5.72739   29.98587  1.000 40.93926  ? 56  ARG A HB2  1 
ATOM   938  H  HB3  . ARG A 1 64  ? -11.87597 6.46368   29.23500  1.000 40.93926  ? 56  ARG A HB3  1 
ATOM   939  H  HG2  . ARG A 1 64  ? -10.55878 4.98127   30.87543  1.000 52.26483  ? 56  ARG A HG2  1 
ATOM   940  H  HG3  . ARG A 1 64  ? -11.80714 4.04905   30.56241  1.000 52.26483  ? 56  ARG A HG3  1 
ATOM   941  H  HD2  . ARG A 1 64  ? -11.19961 4.66619   28.18547  1.000 57.13933  ? 56  ARG A HD2  1 
ATOM   942  H  HD3  . ARG A 1 64  ? -9.75700  4.79932   28.83859  1.000 57.13933  ? 56  ARG A HD3  1 
ATOM   943  H  HE   . ARG A 1 64  ? -10.73944 2.43000   29.42151  1.000 65.36832  ? 56  ARG A HE   1 
ATOM   944  H  HH11 . ARG A 1 64  ? -10.01881 0.53590   28.38009  1.000 75.10285  ? 56  ARG A HH11 1 
ATOM   945  H  HH12 . ARG A 1 64  ? -9.31192  0.62933   27.07227  1.000 75.10285  ? 56  ARG A HH12 1 
ATOM   946  H  HH21 . ARG A 1 64  ? -9.42106  3.92670   26.77701  1.000 65.31076  ? 56  ARG A HH21 1 
ATOM   947  H  HH22 . ARG A 1 64  ? -8.94916  2.68694   26.09943  1.000 65.31076  ? 56  ARG A HH22 1 
ATOM   948  N  N    . ASN A 1 65  ? -12.88693 5.74330   33.06019  1.000 31.96541  ? 57  ASN A N    1 
ATOM   949  C  CA   . ASN A 1 65  ? -12.78671 5.00092   34.31307  1.000 34.58549  ? 57  ASN A CA   1 
ATOM   950  C  C    . ASN A 1 65  ? -12.44565 3.54105   34.04347  1.000 24.59642  ? 57  ASN A C    1 
ATOM   951  O  O    . ASN A 1 65  ? -12.80745 2.97938   33.00999  1.000 26.62813  ? 57  ASN A O    1 
ATOM   952  C  CB   . ASN A 1 65  ? -14.08011 5.12659   35.10881  1.000 35.91685  ? 57  ASN A CB   1 
ATOM   953  C  CG   . ASN A 1 65  ? -14.18705 6.45728   35.79849  1.000 33.15404  ? 57  ASN A CG   1 
ATOM   954  O  OD1  . ASN A 1 65  ? -13.20687 6.98644   36.34502  1.000 47.69363  ? 57  ASN A OD1  1 
ATOM   955  N  ND2  . ASN A 1 65  ? -15.37205 7.01848   35.77249  1.000 46.14886  ? 57  ASN A ND2  1 
ATOM   956  H  H    . ASN A 1 65  ? -13.67416 5.75116   32.71406  1.000 38.33530  ? 57  ASN A H    1 
ATOM   957  H  HA   . ASN A 1 65  ? -12.07260 5.36590   34.85872  1.000 41.47940  ? 57  ASN A HA   1 
ATOM   958  H  HB2  . ASN A 1 65  ? -14.83542 5.03500   34.50712  1.000 43.07703  ? 57  ASN A HB2  1 
ATOM   959  H  HB3  . ASN A 1 65  ? -14.10811 4.43133   35.78463  1.000 43.07703  ? 57  ASN A HB3  1 
ATOM   960  H  HD21 . ASN A 1 65  ? -15.49509 7.78105   36.15056  1.000 55.35544  ? 57  ASN A HD21 1 
ATOM   961  H  HD22 . ASN A 1 65  ? -16.02612 6.62391   35.37736  1.000 55.35544  ? 57  ASN A HD22 1 
ATOM   962  N  N    . VAL A 1 66  ? -11.66392 2.96066   34.94006  1.000 32.79257  ? 58  VAL A N    1 
ATOM   963  C  CA   . VAL A 1 66  ? -11.02805 1.66696   34.73933  1.000 27.28494  ? 58  VAL A CA   1 
ATOM   964  C  C    . VAL A 1 66  ? -11.47733 0.75434   35.86551  1.000 31.76130  ? 58  VAL A C    1 
ATOM   965  O  O    . VAL A 1 66  ? -11.23383 1.05640   37.04190  1.000 33.58900  ? 58  VAL A O    1 
ATOM   966  C  CB   . VAL A 1 66  ? -9.49973  1.79861   34.73089  1.000 33.88852  ? 58  VAL A CB   1 
ATOM   967  C  CG1  . VAL A 1 66  ? -8.83340  0.42977   34.62997  1.000 38.16573  ? 58  VAL A CG1  1 
ATOM   968  C  CG2  . VAL A 1 66  ? -9.05702  2.73007   33.60153  1.000 25.78970  ? 58  VAL A CG2  1 
ATOM   969  H  H    . VAL A 1 66  ? -11.47893 3.31043   35.70363  1.000 39.32790  ? 58  VAL A H    1 
ATOM   970  H  HA   . VAL A 1 66  ? -11.31735 1.28416   33.89632  1.000 32.71874  ? 58  VAL A HA   1 
ATOM   971  H  HB   . VAL A 1 66  ? -9.20932  2.19141   35.56891  1.000 40.64303  ? 58  VAL A HB   1 
ATOM   972  H  HG11 . VAL A 1 66  ? -7.87544  0.55091   34.53756  1.000 45.77569  ? 58  VAL A HG11 1 
ATOM   973  H  HG12 . VAL A 1 66  ? -9.02676  -0.07570  35.43496  1.000 45.77569  ? 58  VAL A HG12 1 
ATOM   974  H  HG13 . VAL A 1 66  ? -9.18425  -0.03586  33.85473  1.000 45.77569  ? 58  VAL A HG13 1 
ATOM   975  H  HG21 . VAL A 1 66  ? -8.08956  2.79958   33.61045  1.000 30.92445  ? 58  VAL A HG21 1 
ATOM   976  H  HG22 . VAL A 1 66  ? -9.35448  2.36288   32.75442  1.000 30.92445  ? 58  VAL A HG22 1 
ATOM   977  H  HG23 . VAL A 1 66  ? -9.45279  3.60474   33.74013  1.000 30.92445  ? 58  VAL A HG23 1 
ATOM   978  N  N    . ARG A 1 67  ? -12.10499 -0.36172  35.50484  1.000 42.26012  ? 59  ARG A N    1 
ATOM   979  C  CA   . ARG A 1 67  ? -12.55177 -1.35361  36.47221  1.000 51.83053  ? 59  ARG A CA   1 
ATOM   980  C  C    . ARG A 1 67  ? -11.35449 -2.08310  37.05830  1.000 43.22621  ? 59  ARG A C    1 
ATOM   981  O  O    . ARG A 1 67  ? -10.58055 -2.70838  36.32665  1.000 47.88364  ? 59  ARG A O    1 
ATOM   982  C  CB   . ARG A 1 67  ? -13.49717 -2.33986  35.79338  1.000 59.12301  ? 59  ARG A CB   1 
ATOM   983  C  CG   . ARG A 1 67  ? -13.89411 -3.54023  36.63166  1.000 73.06342  ? 59  ARG A CG   1 
ATOM   984  C  CD   . ARG A 1 67  ? -15.39569 -3.81812  36.48931  1.000 79.45813  ? 59  ARG A CD   1 
ATOM   985  N  NE   . ARG A 1 67  ? -16.19012 -2.79864  37.17296  1.000 71.96141  ? 59  ARG A NE   1 
ATOM   986  C  CZ   . ARG A 1 67  ? -17.19399 -2.12578  36.61764  1.000 69.78539  ? 59  ARG A CZ   1 
ATOM   987  N  NH1  . ARG A 1 67  ? -17.54811 -2.36060  35.35541  1.000 58.49030  ? 59  ARG A NH1  1 
ATOM   988  N  NH2  . ARG A 1 67  ? -17.84870 -1.21476  37.32860  1.000 78.25630  ? 59  ARG A NH2  1 
ATOM   989  H  H    . ARG A 1 67  ? -12.28678 -0.57048  34.69061  1.000 50.68896  ? 59  ARG A H    1 
ATOM   990  H  HA   . ARG A 1 67  ? -13.02474 -0.91361  37.19581  1.000 62.17345  ? 59  ARG A HA   1 
ATOM   991  H  HB2  . ARG A 1 67  ? -14.31198 -1.86934  35.55760  1.000 70.92442  ? 59  ARG A HB2  1 
ATOM   992  H  HB3  . ARG A 1 67  ? -13.06478 -2.67616  34.99285  1.000 70.92442  ? 59  ARG A HB3  1 
ATOM   993  H  HG2  . ARG A 1 67  ? -13.40479 -4.32247  36.33237  1.000 87.65291  ? 59  ARG A HG2  1 
ATOM   994  H  HG3  . ARG A 1 67  ? -13.69905 -3.36408  37.56538  1.000 87.65291  ? 59  ARG A HG3  1 
ATOM   995  H  HD2  . ARG A 1 67  ? -15.63625 -3.81455  35.54962  1.000 95.32657  ? 59  ARG A HD2  1 
ATOM   996  H  HD3  . ARG A 1 67  ? -15.60215 -4.68101  36.88134  1.000 95.32657  ? 59  ARG A HD3  1 
ATOM   997  H  HE   . ARG A 1 67  ? -15.99455 -2.62168  37.99152  1.000 86.33050  ? 59  ARG A HE   1 
ATOM   998  H  HH11 . ARG A 1 67  ? -17.12670 -2.95091  34.89330  1.000 70.16517  ? 59  ARG A HH11 1 
ATOM   999  H  HH12 . ARG A 1 67  ? -18.19819 -1.92193  35.00247  1.000 70.16517  ? 59  ARG A HH12 1 
ATOM   1000 H  HH21 . ARG A 1 67  ? -17.62291 -1.06214  38.14427  1.000 93.88437  ? 59  ARG A HH21 1 
ATOM   1001 H  HH22 . ARG A 1 67  ? -18.49841 -0.77748  36.97326  1.000 93.88437  ? 59  ARG A HH22 1 
ATOM   1002 N  N    . THR A 1 68  ? -11.20047 -2.00112  38.37348  1.000 38.48806  ? 60  THR A N    1 
ATOM   1003 C  CA   . THR A 1 68  ? -10.11776 -2.66647  39.07871  1.000 39.81124  ? 60  THR A CA   1 
ATOM   1004 C  C    . THR A 1 68  ? -10.68787 -3.61476  40.12615  1.000 50.54800  ? 60  THR A C    1 
ATOM   1005 O  O    . THR A 1 68  ? -11.87961 -3.58918  40.44843  1.000 38.38870  ? 60  THR A O    1 
ATOM   1006 C  CB   . THR A 1 68  ? -9.18171  -1.65520  39.75597  1.000 39.87245  ? 60  THR A CB   1 
ATOM   1007 O  OG1  . THR A 1 68  ? -9.68806  -1.32616  41.05633  1.000 51.09110  ? 60  THR A OG1  1 
ATOM   1008 C  CG2  . THR A 1 68  ? -9.06127  -0.39895  38.92159  1.000 45.32921  ? 60  THR A CG2  1 
ATOM   1009 H  H    . THR A 1 68  ? -11.72403 -1.55477  38.88948  1.000 46.16248  ? 60  THR A H    1 
ATOM   1010 H  HA   . THR A 1 68  ? -9.60134  -3.18076  38.43862  1.000 47.75030  ? 60  THR A HA   1 
ATOM   1011 H  HB   . THR A 1 68  ? -8.29694  -2.04233  39.84659  1.000 47.82376  ? 60  THR A HB   1 
ATOM   1012 H  HG1  . THR A 1 68  ? -9.16814  -0.78920  41.43967  1.000 61.28614  ? 60  THR A HG1  1 
ATOM   1013 H  HG21 . THR A 1 68  ? -8.43498  0.21539   39.33540  1.000 54.37186  ? 60  THR A HG21 1 
ATOM   1014 H  HG22 . THR A 1 68  ? -8.74380  -0.62057  38.03221  1.000 54.37186  ? 60  THR A HG22 1 
ATOM   1015 H  HG23 . THR A 1 68  ? -9.92581  0.03476   38.84825  1.000 54.37186  ? 60  THR A HG23 1 
ATOM   1016 N  N    . HIS A 1 69  ? -9.80464  -4.45734  40.66746  1.000 56.13567  ? 61  HIS A N    1 
ATOM   1017 C  CA   . HIS A 1 69  ? -10.19726 -5.32151  41.77639  1.000 51.31854  ? 61  HIS A CA   1 
ATOM   1018 C  C    . HIS A 1 69  ? -10.74100 -4.50252  42.93873  1.000 48.38281  ? 61  HIS A C    1 
ATOM   1019 O  O    . HIS A 1 69  ? -11.70429 -4.91223  43.59475  1.000 44.34832  ? 61  HIS A O    1 
ATOM   1020 C  CB   . HIS A 1 69  ? -9.00491  -6.17179  42.22676  1.000 55.68611  ? 61  HIS A CB   1 
ATOM   1021 C  CG   . HIS A 1 69  ? -9.30601  -7.06911  43.38793  1.000 59.82731  ? 61  HIS A CG   1 
ATOM   1022 N  ND1  . HIS A 1 69  ? -8.52617  -7.10655  44.52478  1.000 65.66446  ? 61  HIS A ND1  1 
ATOM   1023 C  CD2  . HIS A 1 69  ? -10.29965 -7.96761  43.58441  1.000 55.41194  ? 61  HIS A CD2  1 
ATOM   1024 C  CE1  . HIS A 1 69  ? -9.02939  -7.98633  45.37240  1.000 76.17780  ? 61  HIS A CE1  1 
ATOM   1025 N  NE2  . HIS A 1 69  ? -10.10783 -8.52012  44.82723  1.000 57.53270  ? 61  HIS A NE2  1 
ATOM   1026 H  H    . HIS A 1 69  ? -8.98735  -4.54525  40.41468  1.000 67.33962  ? 61  HIS A H    1 
ATOM   1027 H  HA   . HIS A 1 69  ? -10.89674 -5.92285  41.47634  1.000 61.55906  ? 61  HIS A HA   1 
ATOM   1028 H  HB2  . HIS A 1 69  ? -8.72347  -6.73111  41.48591  1.000 66.80015  ? 61  HIS A HB2  1 
ATOM   1029 H  HB3  . HIS A 1 69  ? -8.28210  -5.58064  42.48942  1.000 66.80015  ? 61  HIS A HB3  1 
ATOM   1030 H  HD2  . HIS A 1 69  ? -10.98415 -8.17242  42.98910  1.000 66.47114  ? 61  HIS A HD2  1 
ATOM   1031 H  HE1  . HIS A 1 69  ? -8.68331  -8.19438  46.21017  1.000 91.39017  ? 61  HIS A HE1  1 
ATOM   1032 N  N    . ASP A 1 70  ? -10.14326 -3.33655  43.20973  1.000 56.93274  ? 62  ASP A N    1 
ATOM   1033 C  CA   . ASP A 1 70  ? -10.57310 -2.51636  44.33764  1.000 54.77440  ? 62  ASP A CA   1 
ATOM   1034 C  C    . ASP A 1 70  ? -11.79596 -1.67820  44.01314  1.000 50.30896  ? 62  ASP A C    1 
ATOM   1035 O  O    . ASP A 1 70  ? -12.43336 -1.15498  44.93612  1.000 54.27423  ? 62  ASP A O    1 
ATOM   1036 C  CB   . ASP A 1 70  ? -9.40826  -1.61430  44.79215  1.000 52.05819  ? 62  ASP A CB   1 
ATOM   1037 C  CG   . ASP A 1 70  ? -8.18260  -2.42527  45.19509  1.000 63.19618  ? 62  ASP A CG   1 
ATOM   1038 O  OD1  . ASP A 1 70  ? -7.31932  -1.87729  45.91234  1.000 63.23433  ? 62  ASP A OD1  1 
ATOM   1039 O  OD2  . ASP A 1 70  ? -8.08351  -3.60774  44.78426  1.000 56.18988  ? 62  ASP A OD2  1 
ATOM   1040 H  H    . ASP A 1 70  ? -9.49202  -3.00417  42.75695  1.000 68.29610  ? 62  ASP A H    1 
ATOM   1041 H  HA   . ASP A 1 70  ? -10.80901 -3.09091  45.08272  1.000 65.70609  ? 62  ASP A HA   1 
ATOM   1042 H  HB2  . ASP A 1 70  ? -9.15655  -1.02645  44.06279  1.000 62.44664  ? 62  ASP A HB2  1 
ATOM   1043 H  HB3  . ASP A 1 70  ? -9.69050  -1.09043  45.55819  1.000 62.44664  ? 62  ASP A HB3  1 
ATOM   1044 N  N    . GLY A 1 71  ? -12.10426 -1.49055  42.73712  1.000 50.17653  ? 63  GLY A N    1 
ATOM   1045 C  CA   . GLY A 1 71  ? -13.21207 -0.67089  42.32150  1.000 36.38290  ? 63  GLY A CA   1 
ATOM   1046 C  C    . GLY A 1 71  ? -12.84853 0.06403   41.05539  1.000 41.68583  ? 63  GLY A C    1 
ATOM   1047 O  O    . GLY A 1 71  ? -11.92698 -0.32533  40.34344  1.000 45.96882  ? 63  GLY A O    1 
ATOM   1048 H  H    . GLY A 1 71  ? -11.66993 -1.84042  42.08249  1.000 60.18865  ? 63  GLY A H    1 
ATOM   1049 H  HA2  . GLY A 1 71  ? -13.99107 -1.22422  42.15452  1.000 43.63630  ? 63  GLY A HA2  1 
ATOM   1050 H  HA3  . GLY A 1 71  ? -13.42582 -0.02501  43.01291  1.000 43.63630  ? 63  GLY A HA3  1 
ATOM   1051 N  N    . ILE A 1 72  ? -13.57623 1.13229   40.77096  1.000 43.15193  ? 64  ILE A N    1 
ATOM   1052 C  CA   . ILE A 1 72  ? -13.30836 1.92915   39.57694  1.000 42.02918  ? 64  ILE A CA   1 
ATOM   1053 C  C    . ILE A 1 72  ? -12.41858 3.11358   39.93635  1.000 34.42313  ? 64  ILE A C    1 
ATOM   1054 O  O    . ILE A 1 72  ? -12.55682 3.72406   40.99944  1.000 32.04241  ? 64  ILE A O    1 
ATOM   1055 C  CB   . ILE A 1 72  ? -14.61654 2.39301   38.90756  1.000 33.81672  ? 64  ILE A CB   1 
ATOM   1056 C  CG1  . ILE A 1 72  ? -15.09681 1.31632   37.93416  1.000 42.88695  ? 64  ILE A CG1  1 
ATOM   1057 C  CG2  . ILE A 1 72  ? -14.36419 3.68678   38.18356  1.000 47.70971  ? 64  ILE A CG2  1 
ATOM   1058 C  CD1  . ILE A 1 72  ? -16.41386 1.63788   37.24346  1.000 46.73595  ? 64  ILE A CD1  1 
ATOM   1059 H  H    . ILE A 1 72  ? -14.23006 1.41802   41.25103  1.000 51.75913  ? 64  ILE A H    1 
ATOM   1060 H  HA   . ILE A 1 72  ? -12.82620 1.37481   38.94358  1.000 50.41183  ? 64  ILE A HA   1 
ATOM   1061 H  HB   . ILE A 1 72  ? -15.30272 2.53325   39.57867  1.000 40.55688  ? 64  ILE A HB   1 
ATOM   1062 H  HG12 . ILE A 1 72  ? -14.42447 1.20007   37.24471  1.000 51.44115  ? 64  ILE A HG12 1 
ATOM   1063 H  HG13 . ILE A 1 72  ? -15.21673 0.48756   38.42372  1.000 51.44115  ? 64  ILE A HG13 1 
ATOM   1064 H  HG21 . ILE A 1 72  ? -15.10782 3.86494   37.58675  1.000 57.22846  ? 64  ILE A HG21 1 
ATOM   1065 H  HG22 . ILE A 1 72  ? -14.28325 4.40198   38.83382  1.000 57.22846  ? 64  ILE A HG22 1 
ATOM   1066 H  HG23 . ILE A 1 72  ? -13.54254 3.60847   37.67400  1.000 57.22846  ? 64  ILE A HG23 1 
ATOM   1067 H  HD11 . ILE A 1 72  ? -16.68536 0.87452   36.71010  1.000 56.05995  ? 64  ILE A HD11 1 
ATOM   1068 H  HD12 . ILE A 1 72  ? -17.08587 1.82657   37.91703  1.000 56.05995  ? 64  ILE A HD12 1 
ATOM   1069 H  HD13 . ILE A 1 72  ? -16.29044 2.41276   36.67317  1.000 56.05995  ? 64  ILE A HD13 1 
ATOM   1070 N  N    . VAL A 1 73  ? -11.47104 3.40906   39.05007  1.000 40.45128  ? 65  VAL A N    1 
ATOM   1071 C  CA   . VAL A 1 73  ? -10.58232 4.55457   39.15780  1.000 29.67764  ? 65  VAL A CA   1 
ATOM   1072 C  C    . VAL A 1 73  ? -10.56541 5.23592   37.79468  1.000 28.46223  ? 65  VAL A C    1 
ATOM   1073 O  O    . VAL A 1 73  ? -11.02414 4.67961   36.79486  1.000 32.40207  ? 65  VAL A O    1 
ATOM   1074 C  CB   . VAL A 1 73  ? -9.15890  4.13786   39.58680  1.000 27.50772  ? 65  VAL A CB   1 
ATOM   1075 C  CG1  . VAL A 1 73  ? -9.20658  3.44496   40.95201  1.000 36.43625  ? 65  VAL A CG1  1 
ATOM   1076 C  CG2  . VAL A 1 73  ? -8.52105  3.20471   38.52963  1.000 23.42501  ? 65  VAL A CG2  1 
ATOM   1077 H  H    . VAL A 1 73  ? -11.31966 2.93721   38.34720  1.000 48.51834  ? 65  VAL A H    1 
ATOM   1078 H  HA   . VAL A 1 73  ? -10.91570 5.18351   39.81673  1.000 35.58998  ? 65  VAL A HA   1 
ATOM   1079 H  HB   . VAL A 1 73  ? -8.60508  4.93092   39.65921  1.000 32.98607  ? 65  VAL A HB   1 
ATOM   1080 H  HG11 . VAL A 1 73  ? -8.30803  3.17933   41.20290  1.000 43.70032  ? 65  VAL A HG11 1 
ATOM   1081 H  HG12 . VAL A 1 73  ? -9.56386  4.06382   41.60796  1.000 43.70032  ? 65  VAL A HG12 1 
ATOM   1082 H  HG13 . VAL A 1 73  ? -9.77735  2.66314   40.88959  1.000 43.70032  ? 65  VAL A HG13 1 
ATOM   1083 H  HG21 . VAL A 1 73  ? -7.65014  2.91782   38.84601  1.000 28.08683  ? 65  VAL A HG21 1 
ATOM   1084 H  HG22 . VAL A 1 73  ? -9.09620  2.43440   38.40024  1.000 28.08683  ? 65  VAL A HG22 1 
ATOM   1085 H  HG23 . VAL A 1 73  ? -8.42637  3.69066   37.69549  1.000 28.08683  ? 65  VAL A HG23 1 
ATOM   1086 N  N    . THR A 1 74  ? -10.01425 6.44200   37.75362  1.000 21.69561  ? 66  THR A N    1 
ATOM   1087 C  CA   . THR A 1 74  ? -9.81842  7.08640   36.46518  1.000 25.07518  ? 66  THR A CA   1 
ATOM   1088 C  C    . THR A 1 74  ? -8.61083  6.48299   35.74057  1.000 23.41932  ? 66  THR A C    1 
ATOM   1089 O  O    . THR A 1 74  ? -7.74598  5.82807   36.33409  1.000 17.39450  ? 66  THR A O    1 
ATOM   1090 C  CB   . THR A 1 74  ? -9.62221  8.59610   36.62489  1.000 23.63407  ? 66  THR A CB   1 
ATOM   1091 O  OG1  . THR A 1 74  ? -8.37625  8.84639   37.28570  1.000 25.11537  ? 66  THR A OG1  1 
ATOM   1092 C  CG2  . THR A 1 74  ? -10.77567 9.21117   37.42241  1.000 27.45935  ? 66  THR A CG2  1 
ATOM   1093 H  H    . THR A 1 74  ? -9.75336  6.89372   38.43735  1.000 26.01154  ? 66  THR A H    1 
ATOM   1094 H  HA   . THR A 1 74  ? -10.60942 6.94503   35.92183  1.000 30.06703  ? 66  THR A HA   1 
ATOM   1095 H  HB   . THR A 1 74  ? -9.60978  9.01956   35.75229  1.000 28.33770  ? 66  THR A HB   1 
ATOM   1096 H  HG1  . THR A 1 74  ? -8.21107  9.66999   37.28507  1.000 30.11526  ? 66  THR A HG1  1 
ATOM   1097 H  HG21 . THR A 1 74  ? -10.65092 10.16995  37.50039  1.000 32.92803  ? 66  THR A HG21 1 
ATOM   1098 H  HG22 . THR A 1 74  ? -11.61822 9.03881   36.97374  1.000 32.92803  ? 66  THR A HG22 1 
ATOM   1099 H  HG23 . THR A 1 74  ? -10.80758 8.82453   38.31145  1.000 32.92803  ? 66  THR A HG23 1 
ATOM   1100 N  N    . LEU A 1 75  ? -8.55987  6.71296   34.42807  1.000 24.40907  ? 67  LEU A N    1 
ATOM   1101 C  CA   . LEU A 1 75  ? -7.41439  6.24062   33.65603  1.000 24.16518  ? 67  LEU A CA   1 
ATOM   1102 C  C    . LEU A 1 75  ? -6.12114  6.86404   34.17228  1.000 26.37252  ? 67  LEU A C    1 
ATOM   1103 O  O    . LEU A 1 75  ? -5.09819  6.17751   34.32128  1.000 16.32908  ? 67  LEU A O    1 
ATOM   1104 C  CB   . LEU A 1 75  ? -7.62603  6.55917   32.17673  1.000 21.69253  ? 67  LEU A CB   1 
ATOM   1105 C  CG   . LEU A 1 75  ? -6.52352  6.09107   31.22549  1.000 26.78396  ? 67  LEU A CG   1 
ATOM   1106 C  CD1  . LEU A 1 75  ? -6.34273  4.56646   31.31526  1.000 24.74273  ? 67  LEU A CD1  1 
ATOM   1107 C  CD2  . LEU A 1 75  ? -6.85406  6.52924   29.79307  1.000 25.15055  ? 67  LEU A CD2  1 
ATOM   1108 H  H    . LEU A 1 75  ? -9.15963  7.12894   33.97327  1.000 29.26770  ? 67  LEU A H    1 
ATOM   1109 H  HA   . LEU A 1 75  ? -7.33677  5.27776   33.74422  1.000 28.97503  ? 67  LEU A HA   1 
ATOM   1110 H  HB2  . LEU A 1 75  ? -8.45062  6.13560   31.89118  1.000 26.00785  ? 67  LEU A HB2  1 
ATOM   1111 H  HB3  . LEU A 1 75  ? -7.69747  7.52188   32.08195  1.000 26.00785  ? 67  LEU A HB3  1 
ATOM   1112 H  HG   . LEU A 1 75  ? -5.67923  6.49637   31.47812  1.000 32.11756  ? 67  LEU A HG   1 
ATOM   1113 H  HD11 . LEU A 1 75  ? -5.67852  4.28840   30.66533  1.000 29.66808  ? 67  LEU A HD11 1 
ATOM   1114 H  HD12 . LEU A 1 75  ? -6.04711  4.33563   32.20981  1.000 29.66808  ? 67  LEU A HD12 1 
ATOM   1115 H  HD13 . LEU A 1 75  ? -7.19119  4.13615   31.12593  1.000 29.66808  ? 67  LEU A HD13 1 
ATOM   1116 H  HD21 . LEU A 1 75  ? -6.17249  6.18790   29.19319  1.000 30.15747  ? 67  LEU A HD21 1 
ATOM   1117 H  HD22 . LEU A 1 75  ? -7.72135  6.17209   29.54576  1.000 30.15747  ? 67  LEU A HD22 1 
ATOM   1118 H  HD23 . LEU A 1 75  ? -6.87249  7.49834   29.75557  1.000 30.15747  ? 67  LEU A HD23 1 
ATOM   1119 N  N    . ASP A 1 76  ? -6.16503  8.15416   34.50376  1.000 18.94814  ? 68  ASP A N    1 
ATOM   1120 C  CA   . ASP A 1 76  ? -4.96578  8.83967   34.96737  1.000 17.18219  ? 68  ASP A CA   1 
ATOM   1121 C  C    . ASP A 1 76  ? -4.40868  8.17222   36.21474  1.000 20.99772  ? 68  ASP A C    1 
ATOM   1122 O  O    . ASP A 1 76  ? -3.22980  7.80122   36.26614  1.000 18.51049  ? 68  ASP A O    1 
ATOM   1123 C  CB   . ASP A 1 76  ? -5.27571  10.31140  35.23726  1.000 27.98363  ? 68  ASP A CB   1 
ATOM   1124 C  CG   . ASP A 1 76  ? -4.01393  11.15148  35.39383  1.000 29.88507  ? 68  ASP A CG   1 
ATOM   1125 O  OD1  . ASP A 1 76  ? -3.12536  11.09417  34.51631  1.000 20.41868  ? 68  ASP A OD1  1 
ATOM   1126 O  OD2  . ASP A 1 76  ? -3.89095  11.85278  36.41258  1.000 29.39350  ? 68  ASP A OD2  1 
ATOM   1127 H  H    . ASP A 1 76  ? -6.86856  8.64755   34.46905  1.000 22.71457  ? 68  ASP A H    1 
ATOM   1128 H  HA   . ASP A 1 76  ? -4.29051  8.79732   34.27231  1.000 20.59544  ? 68  ASP A HA   1 
ATOM   1129 H  HB2  . ASP A 1 76  ? -5.78615  10.66974  34.49434  1.000 33.55717  ? 68  ASP A HB2  1 
ATOM   1130 H  HB3  . ASP A 1 76  ? -5.78887  10.38254  36.05733  1.000 33.55717  ? 68  ASP A HB3  1 
ATOM   1131 N  N    . GLU A 1 77  ? -5.25023  7.99568   37.23226  1.000 19.53707  ? 69  GLU A N    1 
ATOM   1132 C  CA   . GLU A 1 77  ? -4.75897  7.42544   38.47602  1.000 21.25192  ? 69  GLU A CA   1 
ATOM   1133 C  C    . GLU A 1 77  ? -4.50461  5.93422   38.35426  1.000 18.67989  ? 69  GLU A C    1 
ATOM   1134 O  O    . GLU A 1 77  ? -3.73119  5.39666   39.14708  1.000 21.01905  ? 69  GLU A O    1 
ATOM   1135 C  CB   . GLU A 1 77  ? -5.72642  7.71297   39.62442  1.000 29.02325  ? 69  GLU A CB   1 
ATOM   1136 C  CG   . GLU A 1 77  ? -7.10456  7.14713   39.43366  1.000 35.86735  ? 69  GLU A CG   1 
ATOM   1137 C  CD   . GLU A 1 77  ? -8.17334  7.92888   40.20225  1.000 30.62111  ? 69  GLU A CD   1 
ATOM   1138 O  OE1  . GLU A 1 77  ? -7.82300  8.87019   40.94654  1.000 40.37698  ? 69  GLU A OE1  1 
ATOM   1139 O  OE2  . GLU A 1 77  ? -9.36818  7.58414   40.08344  1.000 35.30902  ? 69  GLU A OE2  1 
ATOM   1140 H  H    . GLU A 1 77  ? -6.08712  8.19356   37.22486  1.000 23.42129  ? 69  GLU A H    1 
ATOM   1141 H  HA   . GLU A 1 77  ? -3.91884  7.85378   38.70319  1.000 25.47912  ? 69  GLU A HA   1 
ATOM   1142 H  HB2  . GLU A 1 77  ? -5.36256  7.33031   40.43811  1.000 34.80471  ? 69  GLU A HB2  1 
ATOM   1143 H  HB3  . GLU A 1 77  ? -5.81497  8.67412   39.72053  1.000 34.80471  ? 69  GLU A HB3  1 
ATOM   1144 H  HG2  . GLU A 1 77  ? -7.33096  7.17583   38.49088  1.000 43.01763  ? 69  GLU A HG2  1 
ATOM   1145 H  HG3  . GLU A 1 77  ? -7.11705  6.23028   39.75009  1.000 43.01763  ? 69  GLU A HG3  1 
ATOM   1146 N  N    . TYR A 1 78  ? -5.11478  5.25806   37.37675  1.000 19.86126  ? 70  TYR A N    1 
ATOM   1147 C  CA   . TYR A 1 78  ? -4.72377  3.88233   37.08311  1.000 22.30692  ? 70  TYR A CA   1 
ATOM   1148 C  C    . TYR A 1 78  ? -3.29465  3.82763   36.55694  1.000 22.18506  ? 70  TYR A C    1 
ATOM   1149 O  O    . TYR A 1 78  ? -2.46905  3.04146   37.03798  1.000 19.57746  ? 70  TYR A O    1 
ATOM   1150 C  CB   . TYR A 1 78  ? -5.68463  3.26537   36.06532  1.000 21.49664  ? 70  TYR A CB   1 
ATOM   1151 C  CG   . TYR A 1 78  ? -5.27413  1.87820   35.61354  1.000 23.73820  ? 70  TYR A CG   1 
ATOM   1152 C  CD1  . TYR A 1 78  ? -5.64630  0.75640   36.33210  1.000 26.42852  ? 70  TYR A CD1  1 
ATOM   1153 C  CD2  . TYR A 1 78  ? -4.50683  1.69388   34.47421  1.000 21.12563  ? 70  TYR A CD2  1 
ATOM   1154 C  CE1  . TYR A 1 78  ? -5.27814  -0.50291  35.92534  1.000 26.12820  ? 70  TYR A CE1  1 
ATOM   1155 C  CE2  . TYR A 1 78  ? -4.12333  0.42674   34.06320  1.000 19.85778  ? 70  TYR A CE2  1 
ATOM   1156 C  CZ   . TYR A 1 78  ? -4.51905  -0.66005  34.78989  1.000 28.33109  ? 70  TYR A CZ   1 
ATOM   1157 O  OH   . TYR A 1 78  ? -4.15292  -1.91757  34.39710  1.000 32.27318  ? 70  TYR A OH   1 
ATOM   1158 H  H    . TYR A 1 78  ? -5.74479  5.56821   36.88026  1.000 23.81032  ? 70  TYR A H    1 
ATOM   1159 H  HA   . TYR A 1 78  ? -4.77453  3.36272   37.90062  1.000 26.74511  ? 70  TYR A HA   1 
ATOM   1160 H  HB2  . TYR A 1 78  ? -6.56541  3.19922   36.46626  1.000 25.77278  ? 70  TYR A HB2  1 
ATOM   1161 H  HB3  . TYR A 1 78  ? -5.71895  3.83560   35.28138  1.000 25.77278  ? 70  TYR A HB3  1 
ATOM   1162 H  HD1  . TYR A 1 78  ? -6.15480  0.85654   37.10430  1.000 31.69104  ? 70  TYR A HD1  1 
ATOM   1163 H  HD2  . TYR A 1 78  ? -4.24433  2.43410   33.97615  1.000 25.32757  ? 70  TYR A HD2  1 
ATOM   1164 H  HE1  . TYR A 1 78  ? -5.54166  -1.24723  36.41671  1.000 31.33065  ? 70  TYR A HE1  1 
ATOM   1165 H  HE2  . TYR A 1 78  ? -3.60212  0.31773   33.30073  1.000 23.80614  ? 70  TYR A HE2  1 
ATOM   1166 H  HH   . TYR A 1 78  ? -3.83985  -1.89543  33.61794  1.000 38.70462  ? 70  TYR A HH   1 
ATOM   1167 N  N    . LEU A 1 79  ? -2.98743  4.66672   35.56665  1.000 17.39174  ? 71  LEU A N    1 
ATOM   1168 C  CA   . LEU A 1 79  ? -1.67237  4.62737   34.94020  1.000 22.03755  ? 71  LEU A CA   1 
ATOM   1169 C  C    . LEU A 1 79  ? -0.58757  5.08068   35.90285  1.000 24.23208  ? 71  LEU A C    1 
ATOM   1170 O  O    . LEU A 1 79  ? 0.50325   4.49858   35.92926  1.000 25.24455  ? 71  LEU A O    1 
ATOM   1171 C  CB   . LEU A 1 79  ? -1.66462  5.49946   33.68646  1.000 16.40668  ? 71  LEU A CB   1 
ATOM   1172 C  CG   . LEU A 1 79  ? -2.58924  5.05677   32.55681  1.000 18.92399  ? 71  LEU A CG   1 
ATOM   1173 C  CD1  . LEU A 1 79  ? -2.59511  6.11234   31.44678  1.000 19.12446  ? 71  LEU A CD1  1 
ATOM   1174 C  CD2  . LEU A 1 79  ? -2.15509  3.70717   32.00297  1.000 25.02231  ? 71  LEU A CD2  1 
ATOM   1175 H  H    . LEU A 1 79  ? -3.51828  5.26132   35.24377  1.000 20.84689  ? 71  LEU A H    1 
ATOM   1176 H  HA   . LEU A 1 79  ? -1.48126  3.71342   34.67737  1.000 26.42187  ? 71  LEU A HA   1 
ATOM   1177 H  HB2  . LEU A 1 79  ? -1.93145  6.39669   33.94080  1.000 19.66483  ? 71  LEU A HB2  1 
ATOM   1178 H  HB3  . LEU A 1 79  ? -0.76208  5.50991   33.33118  1.000 19.66483  ? 71  LEU A HB3  1 
ATOM   1179 H  HG   . LEU A 1 79  ? -3.49120  4.96033   32.90041  1.000 22.68559  ? 71  LEU A HG   1 
ATOM   1180 H  HD11 . LEU A 1 79  ? -3.18082  5.81625   30.73251  1.000 22.92616  ? 71  LEU A HD11 1 
ATOM   1181 H  HD12 . LEU A 1 79  ? -2.91614  6.95202   31.81116  1.000 22.92616  ? 71  LEU A HD12 1 
ATOM   1182 H  HD13 . LEU A 1 79  ? -1.69199  6.22160   31.11011  1.000 22.92616  ? 71  LEU A HD13 1 
ATOM   1183 H  HD21 . LEU A 1 79  ? -2.73083  3.47118   31.25883  1.000 30.00358  ? 71  LEU A HD21 1 
ATOM   1184 H  HD22 . LEU A 1 79  ? -1.23505  3.77038   31.70226  1.000 30.00358  ? 71  LEU A HD22 1 
ATOM   1185 H  HD23 . LEU A 1 79  ? -2.22916  3.03988   32.70307  1.000 30.00358  ? 71  LEU A HD23 1 
ATOM   1186 N  N    . LYS A 1 80  ? -0.85974  6.12594   36.69110  1.000 21.50629  ? 72  LYS A N    1 
ATOM   1187 C  CA   . LYS A 1 80  ? 0.15197   6.63401   37.60651  1.000 24.60823  ? 72  LYS A CA   1 
ATOM   1188 C  C    . LYS A 1 80  ? 0.37544   5.69570   38.77818  1.000 22.25718  ? 72  LYS A C    1 
ATOM   1189 O  O    . LYS A 1 80  ? 1.47139   5.68338   39.34258  1.000 30.71291  ? 72  LYS A O    1 
ATOM   1190 C  CB   . LYS A 1 80  ? -0.23643  8.01766   38.11034  1.000 34.75283  ? 72  LYS A CB   1 
ATOM   1191 C  CG   . LYS A 1 80  ? -0.41155  9.04289   36.98517  1.000 42.33129  ? 72  LYS A CG   1 
ATOM   1192 C  CD   . LYS A 1 80  ? -1.59659  9.97502   37.27843  1.000 53.03636  ? 72  LYS A CD   1 
ATOM   1193 C  CE   . LYS A 1 80  ? -1.23757  10.99158  38.36888  1.000 48.78020  ? 72  LYS A CE   1 
ATOM   1194 N  NZ   . LYS A 1 80  ? -0.55438  12.19246  37.79371  1.000 50.08316  ? 72  LYS A NZ   1 
ATOM   1195 H  H    . LYS A 1 80  ? -1.60905  6.54752   36.71148  1.000 25.78436  ? 72  LYS A H    1 
ATOM   1196 H  HA   . LYS A 1 80  ? 0.98847   6.71498   37.12214  1.000 29.50669  ? 72  LYS A HA   1 
ATOM   1197 H  HB2  . LYS A 1 80  ? -1.07782  7.95281   38.58864  1.000 41.68021  ? 72  LYS A HB2  1 
ATOM   1198 H  HB3  . LYS A 1 80  ? 0.45860   8.34202   38.70416  1.000 41.68021  ? 72  LYS A HB3  1 
ATOM   1199 H  HG2  . LYS A 1 80  ? 0.39198   9.58085   36.90876  1.000 50.77436  ? 72  LYS A HG2  1 
ATOM   1200 H  HG3  . LYS A 1 80  ? -0.58233  8.58107   36.14943  1.000 50.77436  ? 72  LYS A HG3  1 
ATOM   1201 H  HD2  . LYS A 1 80  ? -1.83381  10.45992  36.47251  1.000 63.62045  ? 72  LYS A HD2  1 
ATOM   1202 H  HD3  . LYS A 1 80  ? -2.35277  9.45028   37.58460  1.000 63.62045  ? 72  LYS A HD3  1 
ATOM   1203 H  HE2  . LYS A 1 80  ? -2.04795  11.28525  38.81380  1.000 58.51305  ? 72  LYS A HE2  1 
ATOM   1204 H  HE3  . LYS A 1 80  ? -0.63871  10.57737  39.00974  1.000 58.51305  ? 72  LYS A HE3  1 
ATOM   1205 H  HZ1  . LYS A 1 80  ? -0.36316  12.77291  38.44071  1.000 60.07660  ? 72  LYS A HZ1  1 
ATOM   1206 H  HZ2  . LYS A 1 80  ? 0.20126   11.94919  37.39131  1.000 60.07660  ? 72  LYS A HZ2  1 
ATOM   1207 H  HZ3  . LYS A 1 80  ? -1.08437  12.58806  37.19813  1.000 60.07660  ? 72  LYS A HZ3  1 
ATOM   1208 N  N    . ARG A 1 81  ? -0.63468  4.90247   39.15035  1.000 20.72743  ? 73  ARG A N    1 
ATOM   1209 C  CA   . ARG A 1 81  ? -0.46612  3.90851   40.20591  1.000 25.72591  ? 73  ARG A CA   1 
ATOM   1210 C  C    . ARG A 1 81  ? 0.30304   2.69012   39.70587  1.000 28.08383  ? 73  ARG A C    1 
ATOM   1211 O  O    . ARG A 1 81  ? 1.18567   2.17109   40.39919  1.000 34.03421  ? 73  ARG A O    1 
ATOM   1212 C  CB   . ARG A 1 81  ? -1.83709  3.48494   40.73598  1.000 35.14986  ? 73  ARG A CB   1 
ATOM   1213 C  CG   . ARG A 1 81  ? -1.80002  2.29959   41.68814  1.000 38.77662  ? 73  ARG A CG   1 
ATOM   1214 C  CD   . ARG A 1 81  ? -1.15711  2.66679   43.02705  1.000 49.17491  ? 73  ARG A CD   1 
ATOM   1215 N  NE   . ARG A 1 81  ? -1.90704  3.70211   43.74197  1.000 51.29817  ? 73  ARG A NE   1 
ATOM   1216 C  CZ   . ARG A 1 81  ? -3.01064  3.47981   44.45074  1.000 50.75175  ? 73  ARG A CZ   1 
ATOM   1217 N  NH1  . ARG A 1 81  ? -3.50687  2.25023   44.55518  1.000 50.91361  ? 73  ARG A NH1  1 
ATOM   1218 N  NH2  . ARG A 1 81  ? -3.61851  4.49005   45.05873  1.000 48.77897  ? 73  ARG A NH2  1 
ATOM   1219 H  H    . ARG A 1 81  ? -1.42304  4.92186   38.80726  1.000 24.84972  ? 73  ARG A H    1 
ATOM   1220 H  HA   . ARG A 1 81  ? 0.03638   4.30365   40.93548  1.000 30.84790  ? 73  ARG A HA   1 
ATOM   1221 H  HB2  . ARG A 1 81  ? -2.22951  4.23293   41.21287  1.000 42.15664  ? 73  ARG A HB2  1 
ATOM   1222 H  HB3  . ARG A 1 81  ? -2.39811  3.24015   39.98349  1.000 42.15664  ? 73  ARG A HB3  1 
ATOM   1223 H  HG2  . ARG A 1 81  ? -2.70584  1.99756   41.85892  1.000 46.50875  ? 73  ARG A HG2  1 
ATOM   1224 H  HG3  . ARG A 1 81  ? -1.28147  1.58387   41.28844  1.000 46.50875  ? 73  ARG A HG3  1 
ATOM   1225 H  HD2  . ARG A 1 81  ? -1.12240  1.87741   43.58970  1.000 58.98670  ? 73  ARG A HD2  1 
ATOM   1226 H  HD3  . ARG A 1 81  ? -0.26031  3.00037   42.86777  1.000 58.98670  ? 73  ARG A HD3  1 
ATOM   1227 H  HE   . ARG A 1 81  ? -1.61365  4.50946   43.70068  1.000 61.53461  ? 73  ARG A HE   1 
ATOM   1228 H  HH11 . ARG A 1 81  ? -3.11398  1.59325   44.16324  1.000 61.07314  ? 73  ARG A HH11 1 
ATOM   1229 H  HH12 . ARG A 1 81  ? -4.22061  2.11218   45.01465  1.000 61.07314  ? 73  ARG A HH12 1 
ATOM   1230 H  HH21 . ARG A 1 81  ? -3.29900  5.28587   44.99405  1.000 58.51158  ? 73  ARG A HH21 1 
ATOM   1231 H  HH22 . ARG A 1 81  ? -4.33210  4.34916   45.51757  1.000 58.51158  ? 73  ARG A HH22 1 
ATOM   1232 N  N    . LYS A 1 82  ? -0.02428  2.22049   38.50910  1.000 25.11286  ? 74  LYS A N    1 
ATOM   1233 C  CA   . LYS A 1 82  ? 0.56614   1.00377   37.97311  1.000 23.93585  ? 74  LYS A CA   1 
ATOM   1234 C  C    . LYS A 1 82  ? 1.88111   1.24449   37.24161  1.000 23.01194  ? 74  LYS A C    1 
ATOM   1235 O  O    . LYS A 1 82  ? 2.75816   0.37208   37.27677  1.000 23.16013  ? 74  LYS A O    1 
ATOM   1236 C  CB   . LYS A 1 82  ? -0.43146  0.32522   37.02859  1.000 26.64744  ? 74  LYS A CB   1 
ATOM   1237 C  CG   . LYS A 1 82  ? -0.07361  -1.10019  36.65756  1.000 28.97861  ? 74  LYS A CG   1 
ATOM   1238 C  CD   . LYS A 1 82  ? -1.26138  -1.83148  36.01886  1.000 40.28744  ? 74  LYS A CD   1 
ATOM   1239 C  CE   . LYS A 1 82  ? -2.34737  -2.15022  37.04486  1.000 38.57926  ? 74  LYS A CE   1 
ATOM   1240 N  NZ   . LYS A 1 82  ? -1.84477  -2.92887  38.21078  1.000 33.72399  ? 74  LYS A NZ   1 
ATOM   1241 H  H    . LYS A 1 82  ? -0.59266  2.59289   37.98198  1.000 30.11225  ? 74  LYS A H    1 
ATOM   1242 H  HA   . LYS A 1 82  ? 0.75472   0.39749   38.70644  1.000 28.69983  ? 74  LYS A HA   1 
ATOM   1243 H  HB2  . LYS A 1 82  ? -1.30083  0.30692   37.45842  1.000 31.95373  ? 74  LYS A HB2  1 
ATOM   1244 H  HB3  . LYS A 1 82  ? -0.47821  0.83912   36.20723  1.000 31.95373  ? 74  LYS A HB3  1 
ATOM   1245 H  HG2  . LYS A 1 82  ? 0.65761   -1.09218  36.02025  1.000 34.75114  ? 74  LYS A HG2  1 
ATOM   1246 H  HG3  . LYS A 1 82  ? 0.18801   -1.58394  37.45658  1.000 34.75114  ? 74  LYS A HG3  1 
ATOM   1247 H  HD2  . LYS A 1 82  ? -1.64989  -1.27053  35.32945  1.000 48.32173  ? 74  LYS A HD2  1 
ATOM   1248 H  HD3  . LYS A 1 82  ? -0.95359  -2.66643  35.63281  1.000 48.32173  ? 74  LYS A HD3  1 
ATOM   1249 H  HE2  . LYS A 1 82  ? -2.71734  -1.31842  37.37974  1.000 46.27192  ? 74  LYS A HE2  1 
ATOM   1250 H  HE3  . LYS A 1 82  ? -3.04218  -2.67311  36.61506  1.000 46.27192  ? 74  LYS A HE3  1 
ATOM   1251 H  HZ1  . LYS A 1 82  ? -2.39722  -3.60407  38.38686  1.000 40.44560  ? 74  LYS A HZ1  1 
ATOM   1252 H  HZ2  . LYS A 1 82  ? -1.03643  -3.25596  38.03272  1.000 40.44560  ? 74  LYS A HZ2  1 
ATOM   1253 H  HZ3  . LYS A 1 82  ? -1.79248  -2.40399  38.92763  1.000 40.44560  ? 74  LYS A HZ3  1 
ATOM   1254 N  N    . PHE A 1 83  ? 2.04109   2.39356   36.57828  1.000 20.95447  ? 75  PHE A N    1 
ATOM   1255 C  CA   . PHE A 1 83  ? 3.23167   2.70070   35.78288  1.000 17.58062  ? 75  PHE A CA   1 
ATOM   1256 C  C    . PHE A 1 83  ? 3.69466   4.11692   36.10532  1.000 25.28708  ? 75  PHE A C    1 
ATOM   1257 O  O    . PHE A 1 83  ? 3.55149   5.03689   35.28729  1.000 23.07511  ? 75  PHE A O    1 
ATOM   1258 C  CB   . PHE A 1 83  ? 2.94388   2.54651   34.28891  1.000 19.40815  ? 75  PHE A CB   1 
ATOM   1259 C  CG   . PHE A 1 83  ? 2.26842   1.25108   33.92648  1.000 19.37131  ? 75  PHE A CG   1 
ATOM   1260 C  CD1  . PHE A 1 83  ? 2.89522   0.03465   34.16324  1.000 20.23291  ? 75  PHE A CD1  1 
ATOM   1261 C  CD2  . PHE A 1 83  ? 1.01895   1.24772   33.33204  1.000 16.97018  ? 75  PHE A CD2  1 
ATOM   1262 C  CE1  . PHE A 1 83  ? 2.28886   -1.16390  33.82892  1.000 19.46864  ? 75  PHE A CE1  1 
ATOM   1263 C  CE2  . PHE A 1 83  ? 0.40636   0.04596   32.99300  1.000 20.50191  ? 75  PHE A CE2  1 
ATOM   1264 C  CZ   . PHE A 1 83  ? 1.05318   -1.16350  33.24671  1.000 14.67735  ? 75  PHE A CZ   1 
ATOM   1265 H  H    . PHE A 1 83  ? 1.45798   3.02568   36.57477  1.000 25.12217  ? 75  PHE A H    1 
ATOM   1266 H  HA   . PHE A 1 83  ? 3.94233   2.08630   36.02450  1.000 21.07356  ? 75  PHE A HA   1 
ATOM   1267 H  HB2  . PHE A 1 83  ? 2.36323   3.27084   34.00766  1.000 23.26659  ? 75  PHE A HB2  1 
ATOM   1268 H  HB3  . PHE A 1 83  ? 3.78336   2.58715   33.80465  1.000 23.26659  ? 75  PHE A HB3  1 
ATOM   1269 H  HD1  . PHE A 1 83  ? 3.73902   0.02514   34.55414  1.000 24.25631  ? 75  PHE A HD1  1 
ATOM   1270 H  HD2  . PHE A 1 83  ? 0.58679   2.05270   33.15841  1.000 20.34103  ? 75  PHE A HD2  1 
ATOM   1271 H  HE1  . PHE A 1 83  ? 2.72232   -1.96862  34.00050  1.000 23.33918  ? 75  PHE A HE1  1 
ATOM   1272 H  HE2  . PHE A 1 83  ? -0.43506  0.04880   32.59689  1.000 24.57910  ? 75  PHE A HE2  1 
ATOM   1273 H  HZ   . PHE A 1 83  ? 0.64426   -1.96745  33.02009  1.000 17.58963  ? 75  PHE A HZ   1 
ATOM   1274 N  N    . PRO A 1 84  ? 4.28291   4.31809   37.29169  1.000 19.15657  ? 76  PRO A N    1 
ATOM   1275 C  CA   . PRO A 1 84  ? 4.56419   5.69093   37.74268  1.000 20.47767  ? 76  PRO A CA   1 
ATOM   1276 C  C    . PRO A 1 84  ? 5.58310   6.43135   36.90236  1.000 18.47623  ? 76  PRO A C    1 
ATOM   1277 O  O    . PRO A 1 84  ? 5.49370   7.65822   36.81947  1.000 24.54760  ? 76  PRO A O    1 
ATOM   1278 C  CB   . PRO A 1 84  ? 5.07027   5.50099   39.18060  1.000 26.85959  ? 76  PRO A CB   1 
ATOM   1279 C  CG   . PRO A 1 84  ? 5.55508   4.06111   39.24580  1.000 18.79098  ? 76  PRO A CG   1 
ATOM   1280 C  CD   . PRO A 1 84  ? 4.66497   3.30403   38.29404  1.000 14.79924  ? 76  PRO A CD   1 
ATOM   1281 H  HA   . PRO A 1 84  ? 3.73477   6.19386   37.74770  1.000 24.55001  ? 76  PRO A HA   1 
ATOM   1282 H  HB2  . PRO A 1 84  ? 5.79616   6.11930   39.35861  1.000 32.20831  ? 76  PRO A HB2  1 
ATOM   1283 H  HB3  . PRO A 1 84  ? 4.34535   5.65113   39.80739  1.000 32.20831  ? 76  PRO A HB3  1 
ATOM   1284 H  HG2  . PRO A 1 84  ? 6.48254   4.01190   38.96598  1.000 22.52598  ? 76  PRO A HG2  1 
ATOM   1285 H  HG3  . PRO A 1 84  ? 5.46293   3.72221   40.14999  1.000 22.52598  ? 76  PRO A HG3  1 
ATOM   1286 H  HD2  . PRO A 1 84  ? 5.14932   2.57421   37.87730  1.000 17.73590  ? 76  PRO A HD2  1 
ATOM   1287 H  HD3  . PRO A 1 84  ? 3.88182   2.96283   38.75357  1.000 17.73590  ? 76  PRO A HD3  1 
ATOM   1288 N  N    . GLU A 1 85  ? 6.57176   5.75404   36.31901  1.000 19.55448  ? 77  GLU A N    1 
ATOM   1289 C  CA   . GLU A 1 85  ? 7.59951   6.41748   35.51218  1.000 20.37928  ? 77  GLU A CA   1 
ATOM   1290 C  C    . GLU A 1 85  ? 7.03744   6.64819   34.11486  1.000 24.90754  ? 77  GLU A C    1 
ATOM   1291 O  O    . GLU A 1 85  ? 7.35265   5.92862   33.16172  1.000 25.15849  ? 77  GLU A O    1 
ATOM   1292 C  CB   . GLU A 1 85  ? 8.86279   5.57150   35.43797  1.000 18.15833  ? 77  GLU A CB   1 
ATOM   1293 C  CG   . GLU A 1 85  ? 9.93918   5.92575   36.42017  1.000 38.16385  ? 77  GLU A CG   1 
ATOM   1294 C  CD   . GLU A 1 85  ? 11.23532  5.13647   36.17099  1.000 42.12220  ? 77  GLU A CD   1 
ATOM   1295 O  OE1  . GLU A 1 85  ? 11.17247  3.88449   36.06097  1.000 29.33125  ? 77  GLU A OE1  1 
ATOM   1296 O  OE2  . GLU A 1 85  ? 12.31084  5.77145   36.06661  1.000 36.11621  ? 77  GLU A OE2  1 
ATOM   1297 H  H    . GLU A 1 85  ? 6.67093   4.90164   36.37544  1.000 23.44218  ? 77  GLU A H    1 
ATOM   1298 H  HA   . GLU A 1 85  ? 7.81239   7.26999   35.92305  1.000 24.43195  ? 77  GLU A HA   1 
ATOM   1299 H  HB2  . GLU A 1 85  ? 8.61955   4.64628   35.59830  1.000 21.76680  ? 77  GLU A HB2  1 
ATOM   1300 H  HB3  . GLU A 1 85  ? 9.24082   5.66600   34.54968  1.000 21.76680  ? 77  GLU A HB3  1 
ATOM   1301 H  HG2  . GLU A 1 85  ? 10.14147  6.87131   36.34341  1.000 45.77343  ? 77  GLU A HG2  1 
ATOM   1302 H  HG3  . GLU A 1 85  ? 9.63025   5.72433   37.31733  1.000 45.77343  ? 77  GLU A HG3  1 
ATOM   1303 N  N    . SER A 1 86  ? 6.18664   7.66547   33.99296  1.000 19.19268  ? 78  SER A N    1 
ATOM   1304 C  CA   . SER A 1 86  ? 5.42170   7.83416   32.76411  1.000 22.93507  ? 78  SER A CA   1 
ATOM   1305 C  C    . SER A 1 86  ? 4.97079   9.27892   32.65015  1.000 18.44170  ? 78  SER A C    1 
ATOM   1306 O  O    . SER A 1 86  ? 4.92530   10.01328  33.63789  1.000 19.45397  ? 78  SER A O    1 
ATOM   1307 C  CB   . SER A 1 86  ? 4.20369   6.90052   32.71194  1.000 14.94499  ? 78  SER A CB   1 
ATOM   1308 O  OG   . SER A 1 86  ? 3.27166   7.24088   33.71948  1.000 24.76521  ? 78  SER A OG   1 
ATOM   1309 H  H    . SER A 1 86  ? 6.03869   8.25924   34.59723  1.000 23.00803  ? 78  SER A H    1 
ATOM   1310 H  HA   . SER A 1 86  ? 6.00050   7.63015   32.01293  1.000 27.49890  ? 78  SER A HA   1 
ATOM   1311 H  HB2  . SER A 1 86  ? 3.77729   6.98447   31.84474  1.000 17.91080  ? 78  SER A HB2  1 
ATOM   1312 H  HB3  . SER A 1 86  ? 4.49899   5.98684   32.84938  1.000 17.91080  ? 78  SER A HB3  1 
ATOM   1313 H  HG   . SER A 1 86  ? 2.61328   6.72006   33.68961  1.000 29.69506  ? 78  SER A HG   1 
ATOM   1314 N  N    . ILE A 1 87  ? 4.62742   9.66405   31.42427  1.000 16.30793  ? 79  ILE A N    1 
ATOM   1315 C  CA   . ILE A 1 87  ? 4.10686   10.98602  31.09995  1.000 15.22618  ? 79  ILE A CA   1 
ATOM   1316 C  C    . ILE A 1 87  ? 2.76245   10.76479  30.43463  1.000 14.57084  ? 79  ILE A C    1 
ATOM   1317 O  O    . ILE A 1 87  ? 2.69846   10.13307  29.37326  1.000 20.21594  ? 79  ILE A O    1 
ATOM   1318 C  CB   . ILE A 1 87  ? 5.05013   11.76450  30.16924  1.000 15.08135  ? 79  ILE A CB   1 
ATOM   1319 C  CG1  . ILE A 1 87  ? 6.38389   12.00532  30.86577  1.000 19.32903  ? 79  ILE A CG1  1 
ATOM   1320 C  CG2  . ILE A 1 87  ? 4.42166   13.08186  29.74493  1.000 18.10053  ? 79  ILE A CG2  1 
ATOM   1321 C  CD1  . ILE A 1 87  ? 7.48849   12.47443  29.93698  1.000 27.01017  ? 79  ILE A CD1  1 
ATOM   1322 H  H    . ILE A 1 87  ? 4.69041   9.15361   30.73500  1.000 19.54633  ? 79  ILE A H    1 
ATOM   1323 H  HA   . ILE A 1 87  ? 3.98965   11.50652  31.91003  1.000 18.24823  ? 79  ILE A HA   1 
ATOM   1324 H  HB   . ILE A 1 87  ? 5.20407   11.23376  29.37206  1.000 18.07443  ? 79  ILE A HB   1 
ATOM   1325 H  HG12 . ILE A 1 87  ? 6.26122   12.68597  31.54590  1.000 23.17164  ? 79  ILE A HG12 1 
ATOM   1326 H  HG13 . ILE A 1 87  ? 6.67516   11.17570  31.27540  1.000 23.17164  ? 79  ILE A HG13 1 
ATOM   1327 H  HG21 . ILE A 1 87  ? 5.05536   13.57258  29.19856  1.000 21.69744  ? 79  ILE A HG21 1 
ATOM   1328 H  HG22 . ILE A 1 87  ? 3.61750   12.89821  29.23454  1.000 21.69744  ? 79  ILE A HG22 1 
ATOM   1329 H  HG23 . ILE A 1 87  ? 4.20041   13.59588  30.53723  1.000 21.69744  ? 79  ILE A HG23 1 
ATOM   1330 H  HD11 . ILE A 1 87  ? 8.30644   12.58067  30.44743  1.000 32.38901  ? 79  ILE A HD11 1 
ATOM   1331 H  HD12 . ILE A 1 87  ? 7.61728   11.81241  29.23981  1.000 32.38901  ? 79  ILE A HD12 1 
ATOM   1332 H  HD13 . ILE A 1 87  ? 7.23135   13.32309  29.54383  1.000 32.38901  ? 79  ILE A HD13 1 
ATOM   1333 N  N    . HIS A 1 88  ? 1.69446   11.28967  31.04421  1.000 13.93022  ? 80  HIS A N    1 
ATOM   1334 C  CA   . HIS A 1 88  ? 0.32662   11.08230  30.57279  1.000 17.02386  ? 80  HIS A CA   1 
ATOM   1335 C  C    . HIS A 1 88  ? -0.19806  12.34908  29.91014  1.000 18.14154  ? 80  HIS A C    1 
ATOM   1336 O  O    . HIS A 1 88  ? -0.50993  13.32955  30.59568  1.000 17.53072  ? 80  HIS A O    1 
ATOM   1337 C  CB   . HIS A 1 88  ? -0.58860  10.68051  31.72476  1.000 18.97858  ? 80  HIS A CB   1 
ATOM   1338 C  CG   . HIS A 1 88  ? -1.93200  10.19299  31.28587  1.000 14.12756  ? 80  HIS A CG   1 
ATOM   1339 N  ND1  . HIS A 1 88  ? -3.01190  10.12565  32.13774  1.000 16.76478  ? 80  HIS A ND1  1 
ATOM   1340 C  CD2  . HIS A 1 88  ? -2.36833  9.73789   30.08714  1.000 15.58993  ? 80  HIS A CD2  1 
ATOM   1341 C  CE1  . HIS A 1 88  ? -4.05207  9.63431   31.48830  1.000 18.21666  ? 80  HIS A CE1  1 
ATOM   1342 N  NE2  . HIS A 1 88  ? -3.68617  9.38824   30.24288  1.000 16.32340  ? 80  HIS A NE2  1 
ATOM   1343 H  H    . HIS A 1 88  ? 1.74150   11.78043  31.74887  1.000 16.69307  ? 80  HIS A H    1 
ATOM   1344 H  HA   . HIS A 1 88  ? 0.34580   10.37924  29.90478  1.000 20.40544  ? 80  HIS A HA   1 
ATOM   1345 H  HB2  . HIS A 1 88  ? -0.16399  9.96673   32.22589  1.000 22.75111  ? 80  HIS A HB2  1 
ATOM   1346 H  HB3  . HIS A 1 88  ? -0.72608  11.45145  32.29717  1.000 22.75111  ? 80  HIS A HB3  1 
ATOM   1347 H  HD2  . HIS A 1 88  ? -1.86869  9.67431   29.30534  1.000 18.68473  ? 80  HIS A HD2  1 
ATOM   1348 H  HE1  . HIS A 1 88  ? -4.89751  9.48682   31.84659  1.000 21.83681  ? 80  HIS A HE1  1 
ATOM   1349 N  N    . PHE A 1 89  ? -0.31549  12.31288  28.58142  1.000 16.73798  ? 81  PHE A N    1 
ATOM   1350 C  CA   . PHE A 1 89  ? -0.94173  13.37516  27.79765  1.000 14.99568  ? 81  PHE A CA   1 
ATOM   1351 C  C    . PHE A 1 89  ? -2.36796  12.94199  27.48811  1.000 16.31255  ? 81  PHE A C    1 
ATOM   1352 O  O    . PHE A 1 89  ? -2.60257  12.17576  26.54879  1.000 18.84344  ? 81  PHE A O    1 
ATOM   1353 C  CB   . PHE A 1 89  ? -0.15810  13.64339  26.51763  1.000 13.00706  ? 81  PHE A CB   1 
ATOM   1354 C  CG   . PHE A 1 89  ? 1.16027   14.32374  26.74658  1.000 13.51897  ? 81  PHE A CG   1 
ATOM   1355 C  CD1  . PHE A 1 89  ? 1.22900   15.51808  27.44530  1.000 20.01490  ? 81  PHE A CD1  1 
ATOM   1356 C  CD2  . PHE A 1 89  ? 2.33317   13.77152  26.25691  1.000 13.06375  ? 81  PHE A CD2  1 
ATOM   1357 C  CE1  . PHE A 1 89  ? 2.45452   16.14970  27.65526  1.000 26.74272  ? 81  PHE A CE1  1 
ATOM   1358 C  CE2  . PHE A 1 89  ? 3.55741   14.39426  26.45569  1.000 18.25029  ? 81  PHE A CE2  1 
ATOM   1359 C  CZ   . PHE A 1 89  ? 3.61983   15.58294  27.17062  1.000 20.37521  ? 81  PHE A CZ   1 
ATOM   1360 H  H    . PHE A 1 89  ? -0.03024  11.66154  28.09771  1.000 20.06238  ? 81  PHE A H    1 
ATOM   1361 H  HA   . PHE A 1 89  ? -0.96372  14.19126  28.32149  1.000 17.97162  ? 81  PHE A HA   1 
ATOM   1362 H  HB2  . PHE A 1 89  ? 0.01796   12.79750  26.07675  1.000 15.58528  ? 81  PHE A HB2  1 
ATOM   1363 H  HB3  . PHE A 1 89  ? -0.68938  14.21402  25.94054  1.000 15.58528  ? 81  PHE A HB3  1 
ATOM   1364 H  HD1  . PHE A 1 89  ? 0.45009   15.90246  27.77765  1.000 23.99468  ? 81  PHE A HD1  1 
ATOM   1365 H  HD2  . PHE A 1 89  ? 2.29934   12.96972  25.78694  1.000 15.65331  ? 81  PHE A HD2  1 
ATOM   1366 H  HE1  . PHE A 1 89  ? 2.48849   16.95341  28.12195  1.000 32.06808  ? 81  PHE A HE1  1 
ATOM   1367 H  HE2  . PHE A 1 89  ? 4.33406   14.01634  26.11089  1.000 21.87715  ? 81  PHE A HE2  1 
ATOM   1368 H  HZ   . PHE A 1 89  ? 4.43942   15.99532  27.32266  1.000 24.42706  ? 81  PHE A HZ   1 
ATOM   1369 N  N    . CYS A 1 90  ? -3.31794  13.44405  28.27439  1.000 14.36140  ? 82  CYS A N    1 
ATOM   1370 C  CA   . CYS A 1 90  ? -4.72879  13.09195  28.16919  1.000 13.73439  ? 82  CYS A CA   1 
ATOM   1371 C  C    . CYS A 1 90  ? -5.49892  14.31401  27.68989  1.000 19.76552  ? 82  CYS A C    1 
ATOM   1372 O  O    . CYS A 1 90  ? -5.55304  15.33029  28.39083  1.000 18.72114  ? 82  CYS A O    1 
ATOM   1373 C  CB   . CYS A 1 90  ? -5.27258  12.61156  29.51560  1.000 17.72834  ? 82  CYS A CB   1 
ATOM   1374 S  SG   . CYS A 1 90  ? -7.02607  12.14128  29.52847  1.000 25.80766  ? 82  CYS A SG   1 
ATOM   1375 H  H    . CYS A 1 90  ? -3.16146  14.01275  28.90024  1.000 17.21048  ? 82  CYS A H    1 
ATOM   1376 H  HA   . CYS A 1 90  ? -4.84022  12.37920  27.52076  1.000 16.45807  ? 82  CYS A HA   1 
ATOM   1377 H  HB2  . CYS A 1 90  ? -4.76296  11.83315  29.78994  1.000 21.25082  ? 82  CYS A HB2  1 
ATOM   1378 H  HB3  . CYS A 1 90  ? -5.16063  13.32609  30.16200  1.000 21.25082  ? 82  CYS A HB3  1 
ATOM   1379 H  HG   . CYS A 1 90  ? -7.29346  11.65923  30.59436  1.000 30.94600  ? 82  CYS A HG   1 
ATOM   1380 N  N    . ARG A 1 91  ? -6.10612  14.20552  26.50750  1.000 16.27075  ? 83  ARG A N    1 
ATOM   1381 C  CA   . ARG A 1 91  ? -6.79201  15.34802  25.91361  1.000 18.56353  ? 83  ARG A CA   1 
ATOM   1382 C  C    . ARG A 1 91  ? -7.91042  15.86412  26.80865  1.000 16.99286  ? 83  ARG A C    1 
ATOM   1383 O  O    . ARG A 1 91  ? -8.16715  17.06972  26.84451  1.000 19.42814  ? 83  ARG A O    1 
ATOM   1384 C  CB   . ARG A 1 91  ? -7.33911  14.96055  24.53749  1.000 25.48518  ? 83  ARG A CB   1 
ATOM   1385 C  CG   . ARG A 1 91  ? -6.26169  14.61307  23.50218  1.000 20.14245  ? 83  ARG A CG   1 
ATOM   1386 C  CD   . ARG A 1 91  ? -6.82375  14.68690  22.06891  1.000 17.66542  ? 83  ARG A CD   1 
ATOM   1387 N  NE   . ARG A 1 91  ? -7.28700  16.03253  21.73091  1.000 20.17399  ? 83  ARG A NE   1 
ATOM   1388 C  CZ   . ARG A 1 91  ? -8.53294  16.32761  21.37389  1.000 20.03865  ? 83  ARG A CZ   1 
ATOM   1389 N  NH1  . ARG A 1 91  ? -9.44995  15.37538  21.29799  1.000 33.15283  ? 83  ARG A NH1  1 
ATOM   1390 N  NH2  . ARG A 1 91  ? -8.87773  17.57763  21.10598  1.000 28.08175  ? 83  ARG A NH2  1 
ATOM   1391 H  H    . ARG A 1 91  ? -6.13476  13.48812  26.03409  1.000 19.50171  ? 83  ARG A H    1 
ATOM   1392 H  HA   . ARG A 1 91  ? -6.15643  16.07110  25.79492  1.000 22.25304  ? 83  ARG A HA   1 
ATOM   1393 H  HB2  . ARG A 1 91  ? -7.90987  14.18288  24.63930  1.000 30.55903  ? 83  ARG A HB2  1 
ATOM   1394 H  HB3  . ARG A 1 91  ? -7.85265  15.70548  24.18783  1.000 30.55903  ? 83  ARG A HB3  1 
ATOM   1395 H  HG2  . ARG A 1 91  ? -5.52783  15.24303  23.57632  1.000 24.14775  ? 83  ARG A HG2  1 
ATOM   1396 H  HG3  . ARG A 1 91  ? -5.94177  13.71100  23.65973  1.000 24.14775  ? 83  ARG A HG3  1 
ATOM   1397 H  HD2  . ARG A 1 91  ? -6.12804  14.43907  21.44004  1.000 21.17531  ? 83  ARG A HD2  1 
ATOM   1398 H  HD3  . ARG A 1 91  ? -7.57519  14.07875  21.98898  1.000 21.17531  ? 83  ARG A HD3  1 
ATOM   1399 H  HE   . ARG A 1 91  ? -6.71600  16.67469  21.76542  1.000 24.18560  ? 83  ARG A HE   1 
ATOM   1400 H  HH11 . ARG A 1 91  ? -9.24066  14.56136  21.48011  1.000 39.76021  ? 83  ARG A HH11 1 
ATOM   1401 H  HH12 . ARG A 1 91  ? -10.25481 15.57097  21.06657  1.000 39.76021  ? 83  ARG A HH12 1 
ATOM   1402 H  HH21 . ARG A 1 91  ? -8.29362  18.20630  21.16234  1.000 33.67492  ? 83  ARG A HH21 1 
ATOM   1403 H  HH22 . ARG A 1 91  ? -9.68579  17.76085  20.87562  1.000 33.67492  ? 83  ARG A HH22 1 
ATOM   1404 N  N    . GLU A 1 92  ? -8.58507  14.97923  27.53709  1.000 21.64663  ? 84  GLU A N    1 
ATOM   1405 C  CA   . GLU A 1 92  ? -9.67302  15.42725  28.39827  1.000 24.54634  ? 84  GLU A CA   1 
ATOM   1406 C  C    . GLU A 1 92  ? -9.16539  16.29949  29.53762  1.000 24.48436  ? 84  GLU A C    1 
ATOM   1407 O  O    . GLU A 1 92  ? -9.91472  17.13143  30.05937  1.000 21.51228  ? 84  GLU A O    1 
ATOM   1408 C  CB   . GLU A 1 92  ? -10.43101 14.22236  28.95955  1.000 28.72021  ? 84  GLU A CB   1 
ATOM   1409 C  CG   . GLU A 1 92  ? -11.62110 14.60321  29.80334  1.000 24.79061  ? 84  GLU A CG   1 
ATOM   1410 C  CD   . GLU A 1 92  ? -12.59120 13.45848  30.03782  1.000 30.04424  ? 84  GLU A CD   1 
ATOM   1411 O  OE1  . GLU A 1 92  ? -12.22992 12.30283  29.75716  1.000 27.41121  ? 84  GLU A OE1  1 
ATOM   1412 O  OE2  . GLU A 1 92  ? -13.71889 13.72449  30.50807  1.000 31.15863  ? 84  GLU A OE2  1 
ATOM   1413 H  H    . GLU A 1 92  ? -8.43633  14.13230  27.55072  1.000 25.95277  ? 84  GLU A H    1 
ATOM   1414 H  HA   . GLU A 1 92  ? -10.29085 15.95300  27.86651  1.000 29.43242  ? 84  GLU A HA   1 
ATOM   1415 H  HB2  . GLU A 1 92  ? -10.75100 13.68173  28.22048  1.000 34.44106  ? 84  GLU A HB2  1 
ATOM   1416 H  HB3  . GLU A 1 92  ? -9.82740  13.70305  29.51351  1.000 34.44106  ? 84  GLU A HB3  1 
ATOM   1417 H  HG2  . GLU A 1 92  ? -11.30642 14.90710  30.66910  1.000 29.72554  ? 84  GLU A HG2  1 
ATOM   1418 H  HG3  . GLU A 1 92  ? -12.10552 15.31566  29.35763  1.000 29.72554  ? 84  GLU A HG3  1 
ATOM   1419 N  N    . LEU A 1 93  ? -7.90825  16.12286  29.93660  1.000 19.15421  ? 85  LEU A N    1 
ATOM   1420 C  CA   . LEU A 1 93  ? -7.32150  16.87789  31.03154  1.000 18.07442  ? 85  LEU A CA   1 
ATOM   1421 C  C    . LEU A 1 93  ? -6.52407  18.07983  30.56253  1.000 20.17791  ? 85  LEU A C    1 
ATOM   1422 O  O    . LEU A 1 93  ? -6.09062  18.87630  31.40112  1.000 23.10537  ? 85  LEU A O    1 
ATOM   1423 C  CB   . LEU A 1 93  ? -6.40604  15.97049  31.86113  1.000 25.91694  ? 85  LEU A CB   1 
ATOM   1424 C  CG   . LEU A 1 93  ? -7.03175  14.70728  32.44264  1.000 21.64821  ? 85  LEU A CG   1 
ATOM   1425 C  CD1  . LEU A 1 93  ? -6.00295  13.89909  33.23404  1.000 25.34231  ? 85  LEU A CD1  1 
ATOM   1426 C  CD2  . LEU A 1 93  ? -8.22305  15.06829  33.33035  1.000 22.36262  ? 85  LEU A CD2  1 
ATOM   1427 H  H    . LEU A 1 93  ? -7.36631  15.55881  29.57917  1.000 22.96186  ? 85  LEU A H    1 
ATOM   1428 H  HA   . LEU A 1 93  ? -8.03540  17.19674  31.60563  1.000 21.66611  ? 85  LEU A HA   1 
ATOM   1429 H  HB2  . LEU A 1 93  ? -5.67157  15.68788  31.29405  1.000 31.07714  ? 85  LEU A HB2  1 
ATOM   1430 H  HB3  . LEU A 1 93  ? -6.06804  16.48909  32.60792  1.000 31.07714  ? 85  LEU A HB3  1 
ATOM   1431 H  HG   . LEU A 1 93  ? -7.34690  14.15056  31.71349  1.000 25.95467  ? 85  LEU A HG   1 
ATOM   1432 H  HD11 . LEU A 1 93  ? -6.43523  13.11339  33.60377  1.000 30.38758  ? 85  LEU A HD11 1 
ATOM   1433 H  HD12 . LEU A 1 93  ? -5.28513  13.63236  32.63866  1.000 30.38758  ? 85  LEU A HD12 1 
ATOM   1434 H  HD13 . LEU A 1 93  ? -5.65103  14.45077  33.95008  1.000 30.38758  ? 85  LEU A HD13 1 
ATOM   1435 H  HD21 . LEU A 1 93  ? -8.57307  14.25860  33.73381  1.000 26.81196  ? 85  LEU A HD21 1 
ATOM   1436 H  HD22 . LEU A 1 93  ? -7.92750  15.68124  34.02161  1.000 26.81196  ? 85  LEU A HD22 1 
ATOM   1437 H  HD23 . LEU A 1 93  ? -8.90678  15.48874  32.78570  1.000 26.81196  ? 85  LEU A HD23 1 
ATOM   1438 N  N    . ASP A 1 94  ? -6.31875  18.23425  29.25507  1.000 18.19614  ? 86  ASP A N    1 
ATOM   1439 C  CA   . ASP A 1 94  ? -5.49027  19.32461  28.73851  1.000 15.01639  ? 86  ASP A CA   1 
ATOM   1440 C  C    . ASP A 1 94  ? -5.97296  19.67855  27.34269  1.000 18.51068  ? 86  ASP A C    1 
ATOM   1441 O  O    . ASP A 1 94  ? -5.70096  18.93942  26.39501  1.000 20.46669  ? 86  ASP A O    1 
ATOM   1442 C  CB   . ASP A 1 94  ? -4.02046  18.91351  28.72897  1.000 15.93506  ? 86  ASP A CB   1 
ATOM   1443 C  CG   . ASP A 1 94  ? -3.11647  19.97370  28.15660  1.000 19.80761  ? 86  ASP A CG   1 
ATOM   1444 O  OD1  . ASP A 1 94  ? -3.62659  21.02530  27.72321  1.000 17.77501  ? 86  ASP A OD1  1 
ATOM   1445 O  OD2  . ASP A 1 94  ? -1.88853  19.75022  28.15677  1.000 17.80001  ? 86  ASP A OD2  1 
ATOM   1446 H  H    . ASP A 1 94  ? -6.64727  17.72212  28.64730  1.000 21.81218  ? 86  ASP A H    1 
ATOM   1447 H  HA   . ASP A 1 94  ? -5.59763  20.11049  29.29686  1.000 17.99648  ? 86  ASP A HA   1 
ATOM   1448 H  HB2  . ASP A 1 94  ? -3.73631  18.73825  29.63971  1.000 19.09889  ? 86  ASP A HB2  1 
ATOM   1449 H  HB3  . ASP A 1 94  ? -3.92061  18.11296  28.19041  1.000 19.09889  ? 86  ASP A HB3  1 
ATOM   1450 N  N    . ASN A 1 95  ? -6.66967  20.80805  27.20849  1.000 21.39564  ? 87  ASN A N    1 
ATOM   1451 C  CA   . ASN A 1 95  ? -7.19427  21.23464  25.91909  1.000 23.03366  ? 87  ASN A CA   1 
ATOM   1452 C  C    . ASN A 1 95  ? -6.10648  21.60865  24.92316  1.000 23.36827  ? 87  ASN A C    1 
ATOM   1453 O  O    . ASN A 1 95  ? -6.40828  21.76304  23.73376  1.000 20.36236  ? 87  ASN A O    1 
ATOM   1454 C  CB   . ASN A 1 95  ? -8.12354  22.43564  26.10538  1.000 24.03979  ? 87  ASN A CB   1 
ATOM   1455 C  CG   . ASN A 1 95  ? -9.37073  22.09514  26.89512  1.000 27.55891  ? 87  ASN A CG   1 
ATOM   1456 O  OD1  . ASN A 1 95  ? -9.93526  21.00885  26.73538  1.000 29.78243  ? 87  ASN A OD1  1 
ATOM   1457 N  ND2  . ASN A 1 95  ? -9.81211  23.02441  27.75580  1.000 26.78203  ? 87  ASN A ND2  1 
ATOM   1458 H  H    . ASN A 1 95  ? -6.85151  21.34578  27.85454  1.000 25.65157  ? 87  ASN A H    1 
ATOM   1459 H  HA   . ASN A 1 95  ? -7.70443  20.49894  25.54574  1.000 27.61720  ? 87  ASN A HA   1 
ATOM   1460 H  HB2  . ASN A 1 95  ? -7.64720  23.13272  26.58295  1.000 28.82456  ? 87  ASN A HB2  1 
ATOM   1461 H  HB3  . ASN A 1 95  ? -8.39966  22.75978  25.23383  1.000 28.82456  ? 87  ASN A HB3  1 
ATOM   1462 H  HD21 . ASN A 1 95  ? -10.51668 22.87513  28.22579  1.000 32.11524  ? 87  ASN A HD21 1 
ATOM   1463 H  HD22 . ASN A 1 95  ? -9.39052  23.76951  27.83764  1.000 32.11524  ? 87  ASN A HD22 1 
ATOM   1464 N  N    . ASN A 1 96  ? -4.86442  21.78473  25.37449  1.000 18.55108  ? 88  ASN A N    1 
ATOM   1465 C  CA   . ASN A 1 96  ? -3.79379  22.13051  24.44936  1.000 21.00481  ? 88  ASN A CA   1 
ATOM   1466 C  C    . ASN A 1 96  ? -3.41042  20.96875  23.53215  1.000 22.64949  ? 88  ASN A C    1 
ATOM   1467 O  O    . ASN A 1 96  ? -2.75855  21.19467  22.50715  1.000 20.79507  ? 88  ASN A O    1 
ATOM   1468 C  CB   . ASN A 1 96  ? -2.56214  22.59754  25.22542  1.000 21.58646  ? 88  ASN A CB   1 
ATOM   1469 C  CG   . ASN A 1 96  ? -2.82216  23.84613  26.04576  1.000 20.55312  ? 88  ASN A CG   1 
ATOM   1470 O  OD1  . ASN A 1 96  ? -3.11957  24.90640  25.51389  1.000 21.56688  ? 88  ASN A OD1  1 
ATOM   1471 N  ND2  . ASN A 1 96  ? -2.71490  23.71958  27.34494  1.000 16.63737  ? 88  ASN A ND2  1 
ATOM   1472 H  H    . ASN A 1 96  ? -4.62251  21.71067  26.19643  1.000 22.23811  ? 88  ASN A H    1 
ATOM   1473 H  HA   . ASN A 1 96  ? -4.09824  22.86236  23.89025  1.000 25.18258  ? 88  ASN A HA   1 
ATOM   1474 H  HB2  . ASN A 1 96  ? -2.28502  21.89296  25.83179  1.000 25.88056  ? 88  ASN A HB2  1 
ATOM   1475 H  HB3  . ASN A 1 96  ? -1.84929  22.79447  24.59776  1.000 25.88056  ? 88  ASN A HB3  1 
ATOM   1476 H  HD21 . ASN A 1 96  ? -2.85227  24.39761  27.85582  1.000 19.94165  ? 88  ASN A HD21 1 
ATOM   1477 H  HD22 . ASN A 1 96  ? -2.50709  22.95845  27.68713  1.000 19.94165  ? 88  ASN A HD22 1 
ATOM   1478 N  N    . ILE A 1 97  ? -3.79420  19.74073  23.86476  1.000 20.11064  ? 89  ILE A N    1 
ATOM   1479 C  CA   . ILE A 1 97  ? -3.40777  18.57668  23.06932  1.000 21.66684  ? 89  ILE A CA   1 
ATOM   1480 C  C    . ILE A 1 97  ? -4.36335  18.43092  21.89000  1.000 19.26011  ? 89  ILE A C    1 
ATOM   1481 O  O    . ILE A 1 97  ? -5.57423  18.26588  22.09624  1.000 17.63229  ? 89  ILE A O    1 
ATOM   1482 C  CB   . ILE A 1 97  ? -3.39287  17.30148  23.92602  1.000 20.62794  ? 89  ILE A CB   1 
ATOM   1483 C  CG1  . ILE A 1 97  ? -2.47280  17.48370  25.13860  1.000 16.04377  ? 89  ILE A CG1  1 
ATOM   1484 C  CG2  . ILE A 1 97  ? -2.95548  16.10136  23.08257  1.000 14.98496  ? 89  ILE A CG2  1 
ATOM   1485 C  CD1  . ILE A 1 97  ? -2.66806  16.42181  26.21531  1.000 18.00082  ? 89  ILE A CD1  1 
ATOM   1486 H  H    . ILE A 1 97  ? -4.28054  19.55340  24.54885  1.000 24.10957  ? 89  ILE A H    1 
ATOM   1487 H  HA   . ILE A 1 97  ? -2.51605  18.72325  22.71681  1.000 25.97702  ? 89  ILE A HA   1 
ATOM   1488 H  HB   . ILE A 1 97  ? -4.29161  17.13549  24.25101  1.000 24.73033  ? 89  ILE A HB   1 
ATOM   1489 H  HG12 . ILE A 1 97  ? -1.55063  17.43909  24.84109  1.000 19.22933  ? 89  ILE A HG12 1 
ATOM   1490 H  HG13 . ILE A 1 97  ? -2.65071  18.34908  25.53906  1.000 19.22933  ? 89  ILE A HG13 1 
ATOM   1491 H  HG21 . ILE A 1 97  ? -2.88879  15.32084  23.65461  1.000 17.95876  ? 89  ILE A HG21 1 
ATOM   1492 H  HG22 . ILE A 1 97  ? -3.61435  15.94684  22.38765  1.000 17.95876  ? 89  ILE A HG22 1 
ATOM   1493 H  HG23 . ILE A 1 97  ? -2.09257  16.29361  22.68339  1.000 17.95876  ? 89  ILE A HG23 1 
ATOM   1494 H  HD11 . ILE A 1 97  ? -2.04953  16.59226  26.94282  1.000 21.57779  ? 89  ILE A HD11 1 
ATOM   1495 H  HD12 . ILE A 1 97  ? -3.58099  16.46561  26.54018  1.000 21.57779  ? 89  ILE A HD12 1 
ATOM   1496 H  HD13 . ILE A 1 97  ? -2.49498  15.54776  25.83191  1.000 21.57779  ? 89  ILE A HD13 1 
ATOM   1497 N  N    . PRO A 1 98  ? -3.87591  18.47040  20.65131  1.000 22.38998  ? 90  PRO A N    1 
ATOM   1498 C  CA   . PRO A 1 98  ? -4.77619  18.31625  19.49986  1.000 17.54305  ? 90  PRO A CA   1 
ATOM   1499 C  C    . PRO A 1 98  ? -5.27691  16.88687  19.36342  1.000 19.55010  ? 90  PRO A C    1 
ATOM   1500 O  O    . PRO A 1 98  ? -4.77103  15.95213  19.99297  1.000 23.75648  ? 90  PRO A O    1 
ATOM   1501 C  CB   . PRO A 1 98  ? -3.91090  18.71025  18.29919  1.000 21.04767  ? 90  PRO A CB   1 
ATOM   1502 C  CG   . PRO A 1 98  ? -2.70474  19.43841  18.88421  1.000 22.28450  ? 90  PRO A CG   1 
ATOM   1503 C  CD   . PRO A 1 98  ? -2.49931  18.80817  20.24285  1.000 18.16825  ? 90  PRO A CD   1 
ATOM   1504 H  HA   . PRO A 1 98  ? -5.52810  18.92390  19.57920  1.000 21.02847  ? 90  PRO A HA   1 
ATOM   1505 H  HB2  . PRO A 1 98  ? -3.63383  17.91396  17.81955  1.000 25.23401  ? 90  PRO A HB2  1 
ATOM   1506 H  HB3  . PRO A 1 98  ? -4.41399  19.29410  17.71020  1.000 25.23401  ? 90  PRO A HB3  1 
ATOM   1507 H  HG2  . PRO A 1 98  ? -1.92898  19.30421  18.31757  1.000 26.71821  ? 90  PRO A HG2  1 
ATOM   1508 H  HG3  . PRO A 1 98  ? -2.89625  20.38583  18.96556  1.000 26.71821  ? 90  PRO A HG3  1 
ATOM   1509 H  HD2  . PRO A 1 98  ? -1.95028  18.01119  20.17735  1.000 21.77871  ? 90  PRO A HD2  1 
ATOM   1510 H  HD3  . PRO A 1 98  ? -2.09738  19.43800  20.86146  1.000 21.77871  ? 90  PRO A HD3  1 
ATOM   1511 N  N    . ALA A 1 99  ? -6.29510  16.72755  18.51235  1.000 17.15851  ? 91  ALA A N    1 
ATOM   1512 C  CA   . ALA A 1 99  ? -6.83570  15.40079  18.23425  1.000 22.05932  ? 91  ALA A CA   1 
ATOM   1513 C  C    . ALA A 1 99  ? -5.74603  14.49590  17.66372  1.000 19.40015  ? 91  ALA A C    1 
ATOM   1514 O  O    . ALA A 1 99  ? -4.92842  14.91657  16.84211  1.000 20.03461  ? 91  ALA A O    1 
ATOM   1515 C  CB   . ALA A 1 99  ? -8.01221  15.48645  17.25984  1.000 20.33972  ? 91  ALA A CB   1 
ATOM   1516 H  H    . ALA A 1 99  ? -6.68472  17.36658  18.08876  1.000 20.56703  ? 91  ALA A H    1 
ATOM   1517 H  HA   . ALA A 1 99  ? -7.16393  15.01133  19.05977  1.000 26.44799  ? 91  ALA A HA   1 
ATOM   1518 H  HB1  . ALA A 1 99  ? -8.36176  14.59452  17.10759  1.000 24.38447  ? 91  ALA A HB1  1 
ATOM   1519 H  HB2  . ALA A 1 99  ? -8.70100  16.05034  17.64518  1.000 24.38447  ? 91  ALA A HB2  1 
ATOM   1520 H  HB3  . ALA A 1 99  ? -7.70237  15.86754  16.42337  1.000 24.38447  ? 91  ALA A HB3  1 
ATOM   1521 N  N    . LYS A 1 100 ? -5.71604  13.24369  18.11555  1.000 23.34686  ? 92  LYS A N    1 
ATOM   1522 C  CA   . LYS A 1 100 ? -4.57352  12.40416  17.77026  1.000 25.19433  ? 92  LYS A CA   1 
ATOM   1523 C  C    . LYS A 1 100 ? -4.63765  11.88032  16.34100  1.000 20.53578  ? 92  LYS A C    1 
ATOM   1524 O  O    . LYS A 1 100 ? -3.59010  11.68572  15.72082  1.000 20.23658  ? 92  LYS A O    1 
ATOM   1525 C  CB   . LYS A 1 100 ? -4.44384  11.23726  18.74912  1.000 29.66656  ? 92  LYS A CB   1 
ATOM   1526 C  CG   . LYS A 1 100 ? -5.71056  10.48357  19.04075  1.000 31.35710  ? 92  LYS A CG   1 
ATOM   1527 C  CD   . LYS A 1 100 ? -5.61179  9.79494   20.44241  1.000 28.63511  ? 92  LYS A CD   1 
ATOM   1528 C  CE   . LYS A 1 100 ? -4.60500  8.65086   20.41853  1.000 26.53713  ? 92  LYS A CE   1 
ATOM   1529 N  NZ   . LYS A 1 100 ? -4.84831  7.64932   21.51089  1.000 26.19475  ? 92  LYS A NZ   1 
ATOM   1530 H  H    . LYS A 1 100 ? -6.31926  12.87218  18.60310  1.000 27.99305  ? 92  LYS A H    1 
ATOM   1531 H  HA   . LYS A 1 100 ? -3.77354  12.94703  17.84921  1.000 30.21001  ? 92  LYS A HA   1 
ATOM   1532 H  HB2  . LYS A 1 100 ? -3.80957  10.60184  18.38192  1.000 35.57668  ? 92  LYS A HB2  1 
ATOM   1533 H  HB3  . LYS A 1 100 ? -4.11510  11.58404  19.59327  1.000 35.57668  ? 92  LYS A HB3  1 
ATOM   1534 H  HG2  . LYS A 1 100 ? -6.46200  11.09691  19.04750  1.000 37.60533  ? 92  LYS A HG2  1 
ATOM   1535 H  HG3  . LYS A 1 100 ? -5.84675  9.79945   18.36670  1.000 37.60533  ? 92  LYS A HG3  1 
ATOM   1536 H  HD2  . LYS A 1 100 ? -5.32272  10.44461  21.10215  1.000 34.33894  ? 92  LYS A HD2  1 
ATOM   1537 H  HD3  . LYS A 1 100 ? -6.47878  9.43592   20.68805  1.000 34.33894  ? 92  LYS A HD3  1 
ATOM   1538 H  HE2  . LYS A 1 100 ? -4.66882  8.18958   19.56762  1.000 31.82137  ? 92  LYS A HE2  1 
ATOM   1539 H  HE3  . LYS A 1 100 ? -3.71197  9.01143   20.53427  1.000 31.82137  ? 92  LYS A HE3  1 
ATOM   1540 H  HZ1  . LYS A 1 100 ? -4.63583  6.83268   21.22797  1.000 31.41051  ? 92  LYS A HZ1  1 
ATOM   1541 H  HZ2  . LYS A 1 100 ? -4.35073  7.84730   22.22174  1.000 31.41051  ? 92  LYS A HZ2  1 
ATOM   1542 H  HZ3  . LYS A 1 100 ? -5.70632  7.65900   21.74715  1.000 31.41051  ? 92  LYS A HZ3  1 
ATOM   1543 N  N    . GLN A 1 101 ? -5.83388  11.65927  15.79175  1.000 21.54933  ? 93  GLN A N    1 
ATOM   1544 C  CA   . GLN A 1 101 ? -5.93306  11.03890  14.47260  1.000 25.43358  ? 93  GLN A CA   1 
ATOM   1545 C  C    . GLN A 1 101 ? -5.50481  11.98507  13.36061  1.000 28.37983  ? 93  GLN A C    1 
ATOM   1546 O  O    . GLN A 1 101 ? -5.22834  11.53031  12.24500  1.000 25.55201  ? 93  GLN A O    1 
ATOM   1547 C  CB   . GLN A 1 101 ? -7.35993  10.54019  14.22225  1.000 18.14518  ? 93  GLN A CB   1 
ATOM   1548 C  CG   . GLN A 1 101 ? -7.77258  9.43549   15.16625  1.000 21.24412  ? 93  GLN A CG   1 
ATOM   1549 C  CD   . GLN A 1 101 ? -9.14275  8.85752   14.84079  1.000 30.16151  ? 93  GLN A CD   1 
ATOM   1550 O  OE1  . GLN A 1 101 ? -9.43011  8.47321   13.70420  1.000 32.15343  ? 93  GLN A OE1  1 
ATOM   1551 N  NE2  . GLN A 1 101 ? -9.99589  8.80273   15.84071  1.000 29.45660  ? 93  GLN A NE2  1 
ATOM   1552 H  H    . GLN A 1 101 ? -6.58782  11.85571  16.15586  1.000 25.83601  ? 93  GLN A H    1 
ATOM   1553 H  HA   . GLN A 1 101 ? -5.34703  10.26631  14.44862  1.000 30.49711  ? 93  GLN A HA   1 
ATOM   1554 H  HB2  . GLN A 1 101 ? -7.97684  11.27962  14.33871  1.000 21.75102  ? 93  GLN A HB2  1 
ATOM   1555 H  HB3  . GLN A 1 101 ? -7.41945  10.19797  13.31658  1.000 21.75102  ? 93  GLN A HB3  1 
ATOM   1556 H  HG2  . GLN A 1 101 ? -7.12407  8.71615   15.11256  1.000 25.46976  ? 93  GLN A HG2  1 
ATOM   1557 H  HG3  . GLN A 1 101 ? -7.80338  9.78767   16.06953  1.000 25.46976  ? 93  GLN A HG3  1 
ATOM   1558 H  HE21 . GLN A 1 101 ? -9.76412  9.08414   16.61961  1.000 35.32473  ? 93  GLN A HE21 1 
ATOM   1559 H  HE22 . GLN A 1 101 ? -10.78537 8.48551   15.71547  1.000 35.32473  ? 93  GLN A HE22 1 
ATOM   1560 N  N    . THR A 1 102 ? -5.44769  13.28864  13.63135  1.000 27.56718  ? 94  THR A N    1 
ATOM   1561 C  CA   . THR A 1 102 ? -4.90415  14.21315  12.64543  1.000 28.80637  ? 94  THR A CA   1 
ATOM   1562 C  C    . THR A 1 102 ? -3.38819  14.11919  12.54016  1.000 24.88129  ? 94  THR A C    1 
ATOM   1563 O  O    . THR A 1 102 ? -2.81781  14.64636  11.57762  1.000 20.62205  ? 94  THR A O    1 
ATOM   1564 C  CB   . THR A 1 102 ? -5.28201  15.65510  12.98490  1.000 23.29857  ? 94  THR A CB   1 
ATOM   1565 O  OG1  . THR A 1 102 ? -4.63652  16.03850  14.20400  1.000 26.61289  ? 94  THR A OG1  1 
ATOM   1566 C  CG2  . THR A 1 102 ? -6.78344  15.80410  13.14197  1.000 31.43203  ? 94  THR A CG2  1 
ATOM   1567 H  H    . THR A 1 102 ? -5.71232  13.65292  14.36407  1.000 33.05742  ? 94  THR A H    1 
ATOM   1568 H  HA   . THR A 1 102 ? -5.29631  13.99688  11.78500  1.000 34.54446  ? 94  THR A HA   1 
ATOM   1569 H  HB   . THR A 1 102 ? -4.99868  16.23917  12.26414  1.000 27.93509  ? 94  THR A HB   1 
ATOM   1570 H  HG1  . THR A 1 102 ? -4.86340  15.51990  14.82463  1.000 31.91228  ? 94  THR A HG1  1 
ATOM   1571 H  HG21 . THR A 1 102 ? -7.00333  16.71944  13.37588  1.000 37.69525  ? 94  THR A HG21 1 
ATOM   1572 H  HG22 . THR A 1 102 ? -7.22823  15.57610  12.31066  1.000 37.69525  ? 94  THR A HG22 1 
ATOM   1573 H  HG23 . THR A 1 102 ? -7.10386  15.21454  13.84243  1.000 37.69525  ? 94  THR A HG23 1 
ATOM   1574 N  N    . GLY A 1 103 ? -2.73036  13.45703  13.49633  1.000 18.61273  ? 95  GLY A N    1 
ATOM   1575 C  CA   . GLY A 1 103 ? -1.28491  13.44770  13.58619  1.000 18.80984  ? 95  GLY A CA   1 
ATOM   1576 C  C    . GLY A 1 103 ? -0.68920  14.65362  14.28116  1.000 21.97441  ? 95  GLY A C    1 
ATOM   1577 O  O    . GLY A 1 103 ? 0.52354   14.66753  14.53948  1.000 17.10130  ? 95  GLY A O    1 
ATOM   1578 H  H    . GLY A 1 103 ? -3.11515  12.99847  14.11380  1.000 22.31209  ? 95  GLY A H    1 
ATOM   1579 H  HA2  . GLY A 1 103 ? -1.00817  12.65661  14.07455  1.000 22.54862  ? 95  GLY A HA2  1 
ATOM   1580 H  HA3  . GLY A 1 103 ? -0.91720  13.40994  12.68939  1.000 22.54862  ? 95  GLY A HA3  1 
ATOM   1581 N  N    . LYS A 1 104 ? -1.50406  15.65360  14.62279  1.000 18.13199  ? 96  LYS A N    1 
ATOM   1582 C  CA   . LYS A 1 104 ? -0.99363  16.85789  15.26567  1.000 16.95583  ? 96  LYS A CA   1 
ATOM   1583 C  C    . LYS A 1 104 ? -0.61845  16.62985  16.72331  1.000 19.84593  ? 96  LYS A C    1 
ATOM   1584 O  O    . LYS A 1 104 ? 0.18028   17.39363  17.27483  1.000 20.33568  ? 96  LYS A O    1 
ATOM   1585 C  CB   . LYS A 1 104 ? -2.03658  17.96409  15.16471  1.000 22.42765  ? 96  LYS A CB   1 
ATOM   1586 C  CG   . LYS A 1 104 ? -2.17336  18.54134  13.75725  1.000 30.53983  ? 96  LYS A CG   1 
ATOM   1587 C  CD   . LYS A 1 104 ? -1.08063  19.58206  13.48926  1.000 41.24678  ? 96  LYS A CD   1 
ATOM   1588 C  CE   . LYS A 1 104 ? -0.33736  19.29190  12.19408  1.000 43.29335  ? 96  LYS A CE   1 
ATOM   1589 N  NZ   . LYS A 1 104 ? -1.26840  19.21997  11.02679  1.000 42.23000  ? 96  LYS A NZ   1 
ATOM   1590 H  H    . LYS A 1 104 ? -2.35413  15.65698  14.49248  1.000 21.73520  ? 96  LYS A H    1 
ATOM   1591 H  HA   . LYS A 1 104 ? -0.19156  17.14608  14.80250  1.000 20.32380  ? 96  LYS A HA   1 
ATOM   1592 H  HB2  . LYS A 1 104 ? -2.89960  17.60564  15.42471  1.000 26.88999  ? 96  LYS A HB2  1 
ATOM   1593 H  HB3  . LYS A 1 104 ? -1.78475  18.68734  15.76001  1.000 26.88999  ? 96  LYS A HB3  1 
ATOM   1594 H  HG2  . LYS A 1 104 ? -2.08693  17.82883  13.10475  1.000 36.62460  ? 96  LYS A HG2  1 
ATOM   1595 H  HG3  . LYS A 1 104 ? -3.03783  18.97176  13.66592  1.000 36.62460  ? 96  LYS A HG3  1 
ATOM   1596 H  HD2  . LYS A 1 104 ? -1.48488  20.46093  13.41807  1.000 49.47295  ? 96  LYS A HD2  1 
ATOM   1597 H  HD3  . LYS A 1 104 ? -0.43992  19.56959  14.21742  1.000 49.47295  ? 96  LYS A HD3  1 
ATOM   1598 H  HE2  . LYS A 1 104 ? 0.30485   19.99958  12.02780  1.000 51.92884  ? 96  LYS A HE2  1 
ATOM   1599 H  HE3  . LYS A 1 104 ? 0.12018   18.44007  12.27120  1.000 51.92884  ? 96  LYS A HE3  1 
ATOM   1600 H  HZ1  . LYS A 1 104 ? -0.80885  19.27815  10.26684  1.000 50.65281  ? 96  LYS A HZ1  1 
ATOM   1601 H  HZ2  . LYS A 1 104 ? -1.71155  18.44822  11.03798  1.000 50.65281  ? 96  LYS A HZ2  1 
ATOM   1602 H  HZ3  . LYS A 1 104 ? -1.85358  19.88960  11.06245  1.000 50.65281  ? 96  LYS A HZ3  1 
ATOM   1603 N  N    . ALA A 1 105 ? -1.16297  15.59809  17.36317  1.000 16.01362  ? 97  ALA A N    1 
ATOM   1604 C  CA   . ALA A 1 105 ? -0.70697  15.27178  18.70837  1.000 20.48931  ? 97  ALA A CA   1 
ATOM   1605 C  C    . ALA A 1 105 ? 0.78166   14.95397  18.72380  1.000 17.98159  ? 97  ALA A C    1 
ATOM   1606 O  O    . ALA A 1 105 ? 1.45394   15.19212  19.73124  1.000 21.76543  ? 97  ALA A O    1 
ATOM   1607 C  CB   . ALA A 1 105 ? -1.50493  14.09678  19.27559  1.000 18.89981  ? 97  ALA A CB   1 
ATOM   1608 H  H    . ALA A 1 105 ? -1.77938  15.08670  17.04993  1.000 19.19315  ? 97  ALA A H    1 
ATOM   1609 H  HA   . ALA A 1 105 ? -0.86356  16.03742  19.28297  1.000 24.56399  ? 97  ALA A HA   1 
ATOM   1610 H  HB1  . ALA A 1 105 ? -1.18664  13.90178  20.17090  1.000 22.65658  ? 97  ALA A HB1  1 
ATOM   1611 H  HB2  . ALA A 1 105 ? -2.44427  14.33712  19.30351  1.000 22.65658  ? 97  ALA A HB2  1 
ATOM   1612 H  HB3  . ALA A 1 105 ? -1.37818  13.32359  18.70375  1.000 22.65658  ? 97  ALA A HB3  1 
ATOM   1613 N  N    . ILE A 1 106 ? 1.31528   14.40953  17.63016  1.000 19.92700  ? 98  ILE A N    1 
ATOM   1614 C  CA   . ILE A 1 106 ? 2.75671   14.18351  17.55082  1.000 17.89205  ? 98  ILE A CA   1 
ATOM   1615 C  C    . ILE A 1 106 ? 3.49554   15.51321  17.62991  1.000 19.97583  ? 98  ILE A C    1 
ATOM   1616 O  O    . ILE A 1 106 ? 4.46308   15.66669  18.38801  1.000 16.28013  ? 98  ILE A O    1 
ATOM   1617 C  CB   . ILE A 1 106 ? 3.11161   13.42625  16.25816  1.000 19.36024  ? 98  ILE A CB   1 
ATOM   1618 C  CG1  . ILE A 1 106 ? 2.30069   12.13441  16.13317  1.000 26.73547  ? 98  ILE A CG1  1 
ATOM   1619 C  CG2  . ILE A 1 106 ? 4.58769   13.13422  16.19803  1.000 25.06211  ? 98  ILE A CG2  1 
ATOM   1620 C  CD1  . ILE A 1 106 ? 2.30771   11.24974  17.39059  1.000 21.18621  ? 98  ILE A CD1  1 
ATOM   1621 H  H    . ILE A 1 106 ? 0.87313   14.16676  16.93362  1.000 23.88921  ? 98  ILE A H    1 
ATOM   1622 H  HA   . ILE A 1 106 ? 3.02733   13.63604  18.30444  1.000 21.44727  ? 98  ILE A HA   1 
ATOM   1623 H  HB   . ILE A 1 106 ? 2.88007   13.99854  15.50998  1.000 23.20910  ? 98  ILE A HB   1 
ATOM   1624 H  HG12 . ILE A 1 106 ? 1.37802   12.36637  15.94401  1.000 32.05937  ? 98  ILE A HG12 1 
ATOM   1625 H  HG13 . ILE A 1 106 ? 2.66693   11.60950  15.40431  1.000 32.05937  ? 98  ILE A HG13 1 
ATOM   1626 H  HG21 . ILE A 1 106 ? 4.77737   12.63067  15.39096  1.000 30.05134  ? 98  ILE A HG21 1 
ATOM   1627 H  HG22 . ILE A 1 106 ? 5.07530   13.97269  16.18705  1.000 30.05134  ? 98  ILE A HG22 1 
ATOM   1628 H  HG23 . ILE A 1 106 ? 4.83905   12.61559  16.97825  1.000 30.05134  ? 98  ILE A HG23 1 
ATOM   1629 H  HD11 . ILE A 1 106 ? 1.85046   10.41726  17.19358  1.000 25.40027  ? 98  ILE A HD11 1 
ATOM   1630 H  HD12 . ILE A 1 106 ? 3.22630   11.07032  17.64536  1.000 25.40027  ? 98  ILE A HD12 1 
ATOM   1631 H  HD13 . ILE A 1 106 ? 1.85070   11.71648  18.10766  1.000 25.40027  ? 98  ILE A HD13 1 
ATOM   1632 N  N    . ASP A 1 107 ? 3.05077   16.49617  16.83587  1.000 18.46502  ? 99  ASP A N    1 
ATOM   1633 C  CA   . ASP A 1 107 ? 3.69864   17.80427  16.84620  1.000 18.24429  ? 99  ASP A CA   1 
ATOM   1634 C  C    . ASP A 1 107 ? 3.65371   18.41863  18.23446  1.000 15.43864  ? 99  ASP A C    1 
ATOM   1635 O  O    . ASP A 1 107 ? 4.61160   19.06927  18.66709  1.000 19.34442  ? 99  ASP A O    1 
ATOM   1636 C  CB   . ASP A 1 107 ? 3.03795   18.74249  15.83902  1.000 23.50803  ? 99  ASP A CB   1 
ATOM   1637 C  CG   . ASP A 1 107 ? 2.98931   18.15522  14.43649  1.000 28.01467  ? 99  ASP A CG   1 
ATOM   1638 O  OD1  . ASP A 1 107 ? 3.58709   17.08925  14.20188  1.000 27.74144  ? 99  ASP A OD1  1 
ATOM   1639 O  OD2  . ASP A 1 107 ? 2.32757   18.74937  13.57481  1.000 31.34988  ? 99  ASP A OD2  1 
ATOM   1640 H  H    . ASP A 1 107 ? 2.38724   16.42896  16.29290  1.000 22.13484  ? 99  ASP A H    1 
ATOM   1641 H  HA   . ASP A 1 107 ? 4.62499   17.68927  16.58251  1.000 21.86996  ? 99  ASP A HA   1 
ATOM   1642 H  HB2  . ASP A 1 107 ? 2.12736   18.92031  16.12205  1.000 28.18645  ? 99  ASP A HB2  1 
ATOM   1643 H  HB3  . ASP A 1 107 ? 3.54118   19.57086  15.80063  1.000 28.18645  ? 99  ASP A HB3  1 
ATOM   1644 N  N    . PHE A 1 108 ? 2.54761   18.21938  18.95238  1.000 16.80775  ? 100 PHE A N    1 
ATOM   1645 C  CA   . PHE A 1 108 ? 2.46297   18.70758  20.32606  1.000 20.60144  ? 100 PHE A CA   1 
ATOM   1646 C  C    . PHE A 1 108 ? 3.55227   18.08960  21.19727  1.000 17.32400  ? 100 PHE A C    1 
ATOM   1647 O  O    . PHE A 1 108 ? 4.30933   18.79905  21.87350  1.000 19.52215  ? 100 PHE A O    1 
ATOM   1648 C  CB   . PHE A 1 108 ? 1.08343   18.40004  20.90834  1.000 24.00179  ? 100 PHE A CB   1 
ATOM   1649 C  CG   . PHE A 1 108 ? 0.94902   18.76841  22.35434  1.000 26.05694  ? 100 PHE A CG   1 
ATOM   1650 C  CD1  . PHE A 1 108 ? 0.49801   20.02919  22.72049  1.000 24.09800  ? 100 PHE A CD1  1 
ATOM   1651 C  CD2  . PHE A 1 108 ? 1.28371   17.86077  23.34906  1.000 25.66965  ? 100 PHE A CD2  1 
ATOM   1652 C  CE1  . PHE A 1 108 ? 0.36668   20.38250  24.05146  1.000 29.84642  ? 100 PHE A CE1  1 
ATOM   1653 C  CE2  . PHE A 1 108 ? 1.16132   18.20683  24.68681  1.000 31.00104  ? 100 PHE A CE2  1 
ATOM   1654 C  CZ   . PHE A 1 108 ? 0.70310   19.48257  25.03641  1.000 28.78745  ? 100 PHE A CZ   1 
ATOM   1655 H  H    . PHE A 1 108 ? 1.84446   17.81138  18.67181  1.000 20.14611  ? 100 PHE A H    1 
ATOM   1656 H  HA   . PHE A 1 108 ? 2.58497   19.66985  20.31984  1.000 24.69853  ? 100 PHE A HA   1 
ATOM   1657 H  HB2  . PHE A 1 108 ? 0.41599   18.89862  20.41151  1.000 28.77896  ? 100 PHE A HB2  1 
ATOM   1658 H  HB3  . PHE A 1 108 ? 0.91485   17.44824  20.82737  1.000 28.77896  ? 100 PHE A HB3  1 
ATOM   1659 H  HD1  . PHE A 1 108 ? 0.28051   20.64665  22.05993  1.000 28.89441  ? 100 PHE A HD1  1 
ATOM   1660 H  HD2  . PHE A 1 108 ? 1.59221   17.01459  23.11731  1.000 30.78039  ? 100 PHE A HD2  1 
ATOM   1661 H  HE1  . PHE A 1 108 ? 0.05146   21.22702  24.28020  1.000 35.79252  ? 100 PHE A HE1  1 
ATOM   1662 H  HE2  . PHE A 1 108 ? 1.38303   17.59312  25.34946  1.000 37.17806  ? 100 PHE A HE2  1 
ATOM   1663 H  HZ   . PHE A 1 108 ? 0.62629   19.72119  25.93199  1.000 34.52174  ? 100 PHE A HZ   1 
ATOM   1664 N  N    . ILE A 1 109 ? 3.63810   16.76072  21.20037  1.000 18.24171  ? 101 ILE A N    1 
ATOM   1665 C  CA   . ILE A 1 109 ? 4.64375   16.07677  22.00701  1.000 16.14666  ? 101 ILE A CA   1 
ATOM   1666 C  C    . ILE A 1 109 ? 6.03916   16.53959  21.61831  1.000 19.50527  ? 101 ILE A C    1 
ATOM   1667 O  O    . ILE A 1 109 ? 6.89127   16.78243  22.48354  1.000 18.51596  ? 101 ILE A O    1 
ATOM   1668 C  CB   . ILE A 1 109 ? 4.47680   14.55211  21.86604  1.000 23.85715  ? 101 ILE A CB   1 
ATOM   1669 C  CG1  . ILE A 1 109 ? 3.14141   14.12731  22.48356  1.000 20.32605  ? 101 ILE A CG1  1 
ATOM   1670 C  CG2  . ILE A 1 109 ? 5.61864   13.80799  22.54006  1.000 24.21435  ? 101 ILE A CG2  1 
ATOM   1671 C  CD1  . ILE A 1 109 ? 2.73900   12.72169  22.18612  1.000 21.72259  ? 101 ILE A CD1  1 
ATOM   1672 H  H    . ILE A 1 109 ? 3.12954   16.23560  20.74738  1.000 21.86686  ? 101 ILE A H    1 
ATOM   1673 H  HA   . ILE A 1 109 ? 4.51193   16.30634  22.94019  1.000 19.35280  ? 101 ILE A HA   1 
ATOM   1674 H  HB   . ILE A 1 109 ? 4.48889   14.33063  20.92174  1.000 28.60539  ? 101 ILE A HB   1 
ATOM   1675 H  HG12 . ILE A 1 109 ? 3.20511   14.21558  23.44743  1.000 24.36807  ? 101 ILE A HG12 1 
ATOM   1676 H  HG13 . ILE A 1 109 ? 2.44454   14.70946  22.14243  1.000 24.36807  ? 101 ILE A HG13 1 
ATOM   1677 H  HG21 . ILE A 1 109 ? 5.46512   12.85365  22.45894  1.000 29.03403  ? 101 ILE A HG21 1 
ATOM   1678 H  HG22 . ILE A 1 109 ? 6.45190   14.04714  22.10488  1.000 29.03403  ? 101 ILE A HG22 1 
ATOM   1679 H  HG23 . ILE A 1 109 ? 5.65038   14.05950  23.47634  1.000 29.03403  ? 101 ILE A HG23 1 
ATOM   1680 H  HD11 . ILE A 1 109 ? 1.86745   12.55324  22.57716  1.000 26.04392  ? 101 ILE A HD11 1 
ATOM   1681 H  HD12 . ILE A 1 109 ? 2.69890   12.60145  21.22444  1.000 26.04392  ? 101 ILE A HD12 1 
ATOM   1682 H  HD13 . ILE A 1 109 ? 3.39514   12.11785  22.56790  1.000 26.04392  ? 101 ILE A HD13 1 
ATOM   1683 N  N    . MET A 1 110 ? 6.28834   16.69840  20.31542  1.000 20.12314  ? 102 MET A N    1 
ATOM   1684 C  CA   . MET A 1 110 ? 7.60495   17.12749  19.86371  1.000 20.25306  ? 102 MET A CA   1 
ATOM   1685 C  C    . MET A 1 110 ? 7.99667   18.43798  20.52836  1.000 27.49266  ? 102 MET A C    1 
ATOM   1686 O  O    . MET A 1 110 ? 9.12711   18.59588  21.00505  1.000 23.58810  ? 102 MET A O    1 
ATOM   1687 C  CB   . MET A 1 110 ? 7.61773   17.28108  18.34265  1.000 20.11770  ? 102 MET A CB   1 
ATOM   1688 C  CG   . MET A 1 110 ? 7.71716   15.97456  17.55969  1.000 21.66517  ? 102 MET A CG   1 
ATOM   1689 S  SD   . MET A 1 110 ? 7.33483   16.22163  15.79814  1.000 21.54869  ? 102 MET A SD   1 
ATOM   1690 C  CE   . MET A 1 110 ? 8.58519   17.41549  15.34348  1.000 17.94095  ? 102 MET A CE   1 
ATOM   1691 H  H    . MET A 1 110 ? 5.71848   16.56531  19.68523  1.000 24.12458  ? 102 MET A H    1 
ATOM   1692 H  HA   . MET A 1 110 ? 8.25042   16.44176  20.09617  1.000 24.28048  ? 102 MET A HA   1 
ATOM   1693 H  HB2  . MET A 1 110 ? 6.79598   17.71974  18.07207  1.000 24.11805  ? 102 MET A HB2  1 
ATOM   1694 H  HB3  . MET A 1 110 ? 8.38140   17.82599  18.09611  1.000 24.11805  ? 102 MET A HB3  1 
ATOM   1695 H  HG2  . MET A 1 110 ? 8.61969   15.62617  17.63018  1.000 25.97502  ? 102 MET A HG2  1 
ATOM   1696 H  HG3  . MET A 1 110 ? 7.08512   15.33431  17.92232  1.000 25.97502  ? 102 MET A HG3  1 
ATOM   1697 H  HE1  . MET A 1 110 ? 8.47520   17.64728  14.40803  1.000 21.50595  ? 102 MET A HE1  1 
ATOM   1698 H  HE2  . MET A 1 110 ? 8.48153   18.20685  15.89475  1.000 21.50595  ? 102 MET A HE2  1 
ATOM   1699 H  HE3  . MET A 1 110 ? 9.46152   17.02507  15.48669  1.000 21.50595  ? 102 MET A HE3  1 
ATOM   1700 N  N    . ALA A 1 111 ? 7.06633   19.40048  20.55112  1.000 24.32922  ? 103 ALA A N    1 
ATOM   1701 C  CA   . ALA A 1 111 ? 7.36093   20.70975  21.12138  1.000 22.03914  ? 103 ALA A CA   1 
ATOM   1702 C  C    . ALA A 1 111 ? 7.40251   20.65078  22.64193  1.000 22.02965  ? 103 ALA A C    1 
ATOM   1703 O  O    . ALA A 1 111 ? 8.26918   21.26938  23.26823  1.000 27.67966  ? 103 ALA A O    1 
ATOM   1704 C  CB   . ALA A 1 111 ? 6.32367   21.72942  20.65035  1.000 27.49567  ? 103 ALA A CB   1 
ATOM   1705 H  H    . ALA A 1 111 ? 6.26685   19.31784  20.24518  1.000 29.17188  ? 103 ALA A H    1 
ATOM   1706 H  HA   . ALA A 1 111 ? 8.23187   21.00029  20.80840  1.000 26.42378  ? 103 ALA A HA   1 
ATOM   1707 H  HB1  . ALA A 1 111 ? 6.52173   22.58990  21.05190  1.000 32.97161  ? 103 ALA A HB1  1 
ATOM   1708 H  HB2  . ALA A 1 111 ? 6.36478   21.79820  19.68367  1.000 32.97161  ? 103 ALA A HB2  1 
ATOM   1709 H  HB3  . ALA A 1 111 ? 5.44175   21.43202  20.92360  1.000 32.97161  ? 103 ALA A HB3  1 
ATOM   1710 N  N    . ALA A 1 112 ? 6.46797   19.92335  23.25608  1.000 16.52058  ? 104 ALA A N    1 
ATOM   1711 C  CA   . ALA A 1 112 ? 6.43208   19.85071  24.71392  1.000 23.20629  ? 104 ALA A CA   1 
ATOM   1712 C  C    . ALA A 1 112 ? 7.71052   19.23786  25.27123  1.000 31.93795  ? 104 ALA A C    1 
ATOM   1713 O  O    . ALA A 1 112 ? 8.21802   19.67917  26.31110  1.000 36.76166  ? 104 ALA A O    1 
ATOM   1714 C  CB   . ALA A 1 112 ? 5.21515   19.04519  25.17610  1.000 21.37123  ? 104 ALA A CB   1 
ATOM   1715 H  H    . ALA A 1 112 ? 5.85440   19.47073  22.85825  1.000 19.80151  ? 104 ALA A H    1 
ATOM   1716 H  HA   . ALA A 1 112 ? 6.34927   20.75187  25.06313  1.000 27.82436  ? 104 ALA A HA   1 
ATOM   1717 H  HB1  . ALA A 1 112 ? 5.21418   19.00251  26.14516  1.000 25.62228  ? 104 ALA A HB1  1 
ATOM   1718 H  HB2  . ALA A 1 112 ? 4.40861   19.48416  24.86353  1.000 25.62228  ? 104 ALA A HB2  1 
ATOM   1719 H  HB3  . ALA A 1 112 ? 5.26951   18.15036  24.80565  1.000 25.62228  ? 104 ALA A HB3  1 
ATOM   1720 N  N    . LEU A 1 113 ? 8.24059   18.21218  24.60402  1.000 25.42328  ? 105 LEU A N    1 
ATOM   1721 C  CA   . LEU A 1 113 ? 9.42594   17.51313  25.07739  1.000 23.81496  ? 105 LEU A CA   1 
ATOM   1722 C  C    . LEU A 1 113 ? 10.68210  17.88475  24.30439  1.000 23.81779  ? 105 LEU A C    1 
ATOM   1723 O  O    . LEU A 1 113 ? 11.75189  17.33627  24.59301  1.000 18.99877  ? 105 LEU A O    1 
ATOM   1724 C  CB   . LEU A 1 113 ? 9.20947   16.00114  24.99979  1.000 28.53386  ? 105 LEU A CB   1 
ATOM   1725 C  CG   . LEU A 1 113 ? 8.01164   15.45557  25.76980  1.000 27.03586  ? 105 LEU A CG   1 
ATOM   1726 C  CD1  . LEU A 1 113 ? 7.88486   13.93916  25.56239  1.000 29.80320  ? 105 LEU A CD1  1 
ATOM   1727 C  CD2  . LEU A 1 113 ? 8.14263   15.78498  27.23191  1.000 28.32266  ? 105 LEU A CD2  1 
ATOM   1728 H  H    . LEU A 1 113 ? 7.92489   17.90229  23.86653  1.000 30.48475  ? 105 LEU A H    1 
ATOM   1729 H  HA   . LEU A 1 113 ? 9.56976   17.74864  26.00732  1.000 28.55476  ? 105 LEU A HA   1 
ATOM   1730 H  HB2  . LEU A 1 113 ? 9.08525   15.76110  24.06821  1.000 34.21744  ? 105 LEU A HB2  1 
ATOM   1731 H  HB3  . LEU A 1 113 ? 10.00044  15.56416  25.35236  1.000 34.21744  ? 105 LEU A HB3  1 
ATOM   1732 H  HG   . LEU A 1 113 ? 7.19984   15.86961  25.43746  1.000 32.41984  ? 105 LEU A HG   1 
ATOM   1733 H  HD11 . LEU A 1 113 ? 7.12674   13.61299  26.07207  1.000 35.74065  ? 105 LEU A HD11 1 
ATOM   1734 H  HD12 . LEU A 1 113 ? 7.75085   13.75961  24.61862  1.000 35.74065  ? 105 LEU A HD12 1 
ATOM   1735 H  HD13 . LEU A 1 113 ? 8.69880   13.50941  25.86853  1.000 35.74065  ? 105 LEU A HD13 1 
ATOM   1736 H  HD21 . LEU A 1 113 ? 7.40543   15.37914  27.71434  1.000 33.96400  ? 105 LEU A HD21 1 
ATOM   1737 H  HD22 . LEU A 1 113 ? 8.98552   15.43480  27.56024  1.000 33.96400  ? 105 LEU A HD22 1 
ATOM   1738 H  HD23 . LEU A 1 113 ? 8.11941   16.74845  27.34187  1.000 33.96400  ? 105 LEU A HD23 1 
ATOM   1739 N  N    . GLU A 1 114 ? 10.57445  18.78682  23.32896  1.000 25.06729  ? 106 GLU A N    1 
ATOM   1740 C  CA   . GLU A 1 114 ? 11.70893  19.24341  22.52919  1.000 26.25398  ? 106 GLU A CA   1 
ATOM   1741 C  C    . GLU A 1 114 ? 12.41447  18.05194  21.88684  1.000 30.47658  ? 106 GLU A C    1 
ATOM   1742 O  O    . GLU A 1 114 ? 13.61271  17.82172  22.07259  1.000 21.95126  ? 106 GLU A O    1 
ATOM   1743 C  CB   . GLU A 1 114 ? 12.67981  20.07513  23.37602  1.000 26.39177  ? 106 GLU A CB   1 
ATOM   1744 C  CG   . GLU A 1 114 ? 12.13314  21.44168  23.77338  1.000 41.06847  ? 106 GLU A CG   1 
ATOM   1745 C  CD   . GLU A 1 114 ? 12.81962  22.02127  24.99536  1.000 48.12114  ? 106 GLU A CD   1 
ATOM   1746 O  OE1  . GLU A 1 114 ? 14.04560  21.83377  25.13094  1.000 63.20101  ? 106 GLU A OE1  1 
ATOM   1747 O  OE2  . GLU A 1 114 ? 12.13525  22.67208  25.81460  1.000 56.81171  ? 106 GLU A OE2  1 
ATOM   1748 H  H    . GLU A 1 114 ? 9.83216   19.15937  23.10575  1.000 30.05755  ? 106 GLU A H    1 
ATOM   1749 H  HA   . GLU A 1 114 ? 11.37770  19.81441  21.81846  1.000 31.48159  ? 106 GLU A HA   1 
ATOM   1750 H  HB2  . GLU A 1 114 ? 12.87921  19.58772  24.19061  1.000 31.64694  ? 106 GLU A HB2  1 
ATOM   1751 H  HB3  . GLU A 1 114 ? 13.49329  20.21814  22.86740  1.000 31.64694  ? 106 GLU A HB3  1 
ATOM   1752 H  HG2  . GLU A 1 114 ? 12.26236  22.05932  23.03669  1.000 49.25897  ? 106 GLU A HG2  1 
ATOM   1753 H  HG3  . GLU A 1 114 ? 11.18778  21.35705  23.97345  1.000 49.25897  ? 106 GLU A HG3  1 
ATOM   1754 N  N    . LEU A 1 115 ? 11.63446  17.28357  21.12614  1.000 26.53917  ? 107 LEU A N    1 
ATOM   1755 C  CA   . LEU A 1 115 ? 12.13035  16.09343  20.45641  1.000 25.93282  ? 107 LEU A CA   1 
ATOM   1756 C  C    . LEU A 1 115 ? 11.82035  16.18007  18.97048  1.000 24.28439  ? 107 LEU A C    1 
ATOM   1757 O  O    . LEU A 1 115 ? 10.81489  16.77119  18.56595  1.000 20.73280  ? 107 LEU A O    1 
ATOM   1758 C  CB   . LEU A 1 115 ? 11.50574  14.83460  21.04031  1.000 28.08375  ? 107 LEU A CB   1 
ATOM   1759 C  CG   . LEU A 1 115 ? 11.70309  14.57409  22.53881  1.000 26.11632  ? 107 LEU A CG   1 
ATOM   1760 C  CD1  . LEU A 1 115 ? 10.87777  13.35710  22.94839  1.000 23.47052  ? 107 LEU A CD1  1 
ATOM   1761 C  CD2  . LEU A 1 115 ? 13.17138  14.36321  22.84409  1.000 23.58318  ? 107 LEU A CD2  1 
ATOM   1762 H  H    . LEU A 1 115 ? 10.80058  17.43819  20.98352  1.000 31.82381  ? 107 LEU A H    1 
ATOM   1763 H  HA   . LEU A 1 115 ? 13.09289  16.03494  20.56126  1.000 31.09620  ? 107 LEU A HA   1 
ATOM   1764 H  HB2  . LEU A 1 115 ? 10.54898  14.88014  20.88717  1.000 33.67732  ? 107 LEU A HB2  1 
ATOM   1765 H  HB3  . LEU A 1 115 ? 11.88088  14.07282  20.57141  1.000 33.67732  ? 107 LEU A HB3  1 
ATOM   1766 H  HG   . LEU A 1 115 ? 11.40440  15.33866  23.05563  1.000 31.31639  ? 107 LEU A HG   1 
ATOM   1767 H  HD11 . LEU A 1 115 ? 11.00181  13.19609  23.89686  1.000 28.14144  ? 107 LEU A HD11 1 
ATOM   1768 H  HD12 . LEU A 1 115 ? 9.94215   13.53288  22.76230  1.000 28.14144  ? 107 LEU A HD12 1 
ATOM   1769 H  HD13 . LEU A 1 115 ? 11.17709  12.58699  22.44023  1.000 28.14144  ? 107 LEU A HD13 1 
ATOM   1770 H  HD21 . LEU A 1 115 ? 13.27421  14.18294  23.79163  1.000 28.27662  ? 107 LEU A HD21 1 
ATOM   1771 H  HD22 . LEU A 1 115 ? 13.49643  13.60975  22.32685  1.000 28.27662  ? 107 LEU A HD22 1 
ATOM   1772 H  HD23 . LEU A 1 115 ? 13.66202  15.16501  22.60476  1.000 28.27662  ? 107 LEU A HD23 1 
ATOM   1773 N  N    . LYS A 1 116 ? 12.69340  15.58154  18.16321  1.000 16.99059  ? 108 LYS A N    1 
ATOM   1774 C  CA   . LYS A 1 116 ? 12.44937  15.46857  16.73594  1.000 17.47178  ? 108 LYS A CA   1 
ATOM   1775 C  C    . LYS A 1 116 ? 11.41279  14.37953  16.46586  1.000 18.37582  ? 108 LYS A C    1 
ATOM   1776 O  O    . LYS A 1 116 ? 11.17046  13.49731  17.29166  1.000 22.24628  ? 108 LYS A O    1 
ATOM   1777 C  CB   . LYS A 1 116 ? 13.75548  15.16969  15.99854  1.000 23.06346  ? 108 LYS A CB   1 
ATOM   1778 C  CG   . LYS A 1 116 ? 14.54489  16.42685  15.58302  1.000 38.49949  ? 108 LYS A CG   1 
ATOM   1779 C  CD   . LYS A 1 116 ? 15.14680  17.11843  16.77956  1.000 40.35048  ? 108 LYS A CD   1 
ATOM   1780 C  CE   . LYS A 1 116 ? 15.32976  18.61642  16.52559  1.000 61.45367  ? 108 LYS A CE   1 
ATOM   1781 N  NZ   . LYS A 1 116 ? 15.57795  19.38353  17.79303  1.000 54.87878  ? 108 LYS A NZ   1 
ATOM   1782 H  H    . LYS A 1 116 ? 13.43575  15.23287  18.42198  1.000 20.36552  ? 108 LYS A H    1 
ATOM   1783 H  HA   . LYS A 1 116 ? 12.10063  16.30466  16.38917  1.000 20.94295  ? 108 LYS A HA   1 
ATOM   1784 H  HB2  . LYS A 1 116 ? 14.32597  14.64181  16.57886  1.000 27.65296  ? 108 LYS A HB2  1 
ATOM   1785 H  HB3  . LYS A 1 116 ? 13.54987  14.67090  15.19242  1.000 27.65296  ? 108 LYS A HB3  1 
ATOM   1786 H  HG2  . LYS A 1 116 ? 15.26398  16.17184  14.98404  1.000 46.17620  ? 108 LYS A HG2  1 
ATOM   1787 H  HG3  . LYS A 1 116 ? 13.94810  17.04928  15.13882  1.000 46.17620  ? 108 LYS A HG3  1 
ATOM   1788 H  HD2  . LYS A 1 116 ? 14.55988  17.00789  17.54389  1.000 48.39739  ? 108 LYS A HD2  1 
ATOM   1789 H  HD3  . LYS A 1 116 ? 16.01616  16.73279  16.97033  1.000 48.39739  ? 108 LYS A HD3  1 
ATOM   1790 H  HE2  . LYS A 1 116 ? 16.09078  18.74891  15.93891  1.000 73.72122  ? 108 LYS A HE2  1 
ATOM   1791 H  HE3  . LYS A 1 116 ? 14.52651  18.96928  16.11185  1.000 73.72122  ? 108 LYS A HE3  1 
ATOM   1792 H  HZ1  . LYS A 1 116 ? 15.68035  20.24851  17.61023  1.000 65.83135  ? 108 LYS A HZ1  1 
ATOM   1793 H  HZ2  . LYS A 1 116 ? 14.88929  19.28519  18.34817  1.000 65.83135  ? 108 LYS A HZ2  1 
ATOM   1794 H  HZ3  . LYS A 1 116 ? 16.31509  19.08323  18.19121  1.000 65.83135  ? 108 LYS A HZ3  1 
ATOM   1795 N  N    . ARG A 1 117 ? 10.80253  14.44561  15.28255  1.000 22.84889  ? 109 ARG A N    1 
ATOM   1796 C  CA   . ARG A 1 117 ? 9.76831   13.47912  14.92466  1.000 18.85972  ? 109 ARG A CA   1 
ATOM   1797 C  C    . ARG A 1 117 ? 10.28255  12.04262  14.99502  1.000 25.98696  ? 109 ARG A C    1 
ATOM   1798 O  O    . ARG A 1 117 ? 9.62797   11.16833  15.57385  1.000 23.53497  ? 109 ARG A O    1 
ATOM   1799 C  CB   . ARG A 1 117 ? 9.23867   13.78527  13.52783  1.000 20.39934  ? 109 ARG A CB   1 
ATOM   1800 C  CG   . ARG A 1 117 ? 7.87833   13.15996  13.24946  1.000 19.70795  ? 109 ARG A CG   1 
ATOM   1801 C  CD   . ARG A 1 117 ? 7.29264   13.70260  11.95854  1.000 24.15947  ? 109 ARG A CD   1 
ATOM   1802 N  NE   . ARG A 1 117 ? 7.06362   15.14653  12.00822  1.000 22.37408  ? 109 ARG A NE   1 
ATOM   1803 C  CZ   . ARG A 1 117 ? 5.96211   15.70561  12.50087  1.000 30.06995  ? 109 ARG A CZ   1 
ATOM   1804 N  NH1  . ARG A 1 117 ? 4.99237   14.93393  12.98394  1.000 22.55153  ? 109 ARG A NH1  1 
ATOM   1805 N  NH2  . ARG A 1 117 ? 5.81944   17.02864  12.50632  1.000 21.26269  ? 109 ARG A NH2  1 
ATOM   1806 H  H    . ARG A 1 117 ? 10.96710  15.03332  14.67665  1.000 27.39547  ? 109 ARG A H    1 
ATOM   1807 H  HA   . ARG A 1 117 ? 9.04017   13.56213  15.56013  1.000 22.60848  ? 109 ARG A HA   1 
ATOM   1808 H  HB2  . ARG A 1 117 ? 9.15085   14.74625  13.42936  1.000 24.45602  ? 109 ARG A HB2  1 
ATOM   1809 H  HB3  . ARG A 1 117 ? 9.86506   13.44047  12.87236  1.000 24.45602  ? 109 ARG A HB3  1 
ATOM   1810 H  HG2  . ARG A 1 117 ? 7.97462   12.19854  13.16408  1.000 23.62635  ? 109 ARG A HG2  1 
ATOM   1811 H  HG3  . ARG A 1 117 ? 7.27037   13.36930  13.97572  1.000 23.62635  ? 109 ARG A HG3  1 
ATOM   1812 H  HD2  . ARG A 1 117 ? 7.90746   13.52084  11.23063  1.000 28.96818  ? 109 ARG A HD2  1 
ATOM   1813 H  HD3  . ARG A 1 117 ? 6.44144   13.26908  11.78993  1.000 28.96818  ? 109 ARG A HD3  1 
ATOM   1814 H  HE   . ARG A 1 117 ? 7.67749   15.66442  11.70071  1.000 26.82570  ? 109 ARG A HE   1 
ATOM   1815 H  HH11 . ARG A 1 117 ? 5.07969   14.07841  12.97657  1.000 27.03865  ? 109 ARG A HH11 1 
ATOM   1816 H  HH12 . ARG A 1 117 ? 4.27807   15.29053  13.30365  1.000 27.03865  ? 109 ARG A HH12 1 
ATOM   1817 H  HH21 . ARG A 1 117 ? 6.44252   17.52963  12.18950  1.000 25.49203  ? 109 ARG A HH21 1 
ATOM   1818 H  HH22 . ARG A 1 117 ? 5.10415   17.38268  12.82665  1.000 25.49203  ? 109 ARG A HH22 1 
ATOM   1819 N  N    . ASN A 1 118 ? 11.45026  11.77148  14.40653  1.000 19.00816  ? 110 ASN A N    1 
ATOM   1820 C  CA   . ASN A 1 118 ? 11.98906  10.41732  14.37003  1.000 16.01774  ? 110 ASN A CA   1 
ATOM   1821 C  C    . ASN A 1 118 ? 12.88108  10.09926  15.56017  1.000 16.94560  ? 110 ASN A C    1 
ATOM   1822 O  O    . ASN A 1 118 ? 13.67544  9.15614   15.49475  1.000 18.14894  ? 110 ASN A O    1 
ATOM   1823 C  CB   . ASN A 1 118 ? 12.74425  10.18159  13.06355  1.000 22.69122  ? 110 ASN A CB   1 
ATOM   1824 C  CG   . ASN A 1 118 ? 14.00435  11.01383  12.94954  1.000 27.55105  ? 110 ASN A CG   1 
ATOM   1825 O  OD1  . ASN A 1 118 ? 14.18801  12.02194  13.64898  1.000 29.32007  ? 110 ASN A OD1  1 
ATOM   1826 N  ND2  . ASN A 1 118 ? 14.89356  10.58531  12.05923  1.000 31.81433  ? 110 ASN A ND2  1 
ATOM   1827 H  H    . ASN A 1 118 ? 11.94671  12.35903  14.02192  1.000 22.78660  ? 110 ASN A H    1 
ATOM   1828 H  HA   . ASN A 1 118 ? 11.24257  9.79842   14.39505  1.000 19.19809  ? 110 ASN A HA   1 
ATOM   1829 H  HB2  . ASN A 1 118 ? 12.99767  9.24679   13.01034  1.000 27.20628  ? 110 ASN A HB2  1 
ATOM   1830 H  HB3  . ASN A 1 118 ? 12.16598  10.41143  12.31945  1.000 27.20628  ? 110 ASN A HB3  1 
ATOM   1831 H  HD21 . ASN A 1 118 ? 15.63036  11.01431  11.94663  1.000 38.15400  ? 110 ASN A HD21 1 
ATOM   1832 H  HD22 . ASN A 1 118 ? 14.73205  9.87907   11.59583  1.000 38.15400  ? 110 ASN A HD22 1 
ATOM   1833 N  N    . GLU A 1 119 ? 12.76515  10.86018  16.64060  1.000 15.36546  ? 111 GLU A N    1 
ATOM   1834 C  CA   . GLU A 1 119 ? 13.26095  10.45127  17.94410  1.000 15.03736  ? 111 GLU A CA   1 
ATOM   1835 C  C    . GLU A 1 119 ? 12.17430  9.78372   18.76985  1.000 14.18948  ? 111 GLU A C    1 
ATOM   1836 O  O    . GLU A 1 119 ? 12.36827  9.55605   19.96630  1.000 14.77644  ? 111 GLU A O    1 
ATOM   1837 C  CB   . GLU A 1 119 ? 13.82493  11.65068  18.71155  1.000 15.96349  ? 111 GLU A CB   1 
ATOM   1838 C  CG   . GLU A 1 119 ? 15.08675  12.21796  18.12381  1.000 22.24450  ? 111 GLU A CG   1 
ATOM   1839 C  CD   . GLU A 1 119 ? 15.63897  13.38380  18.93096  1.000 29.78527  ? 111 GLU A CD   1 
ATOM   1840 O  OE1  . GLU A 1 119 ? 14.84288  14.23102  19.41378  1.000 22.57723  ? 111 GLU A OE1  1 
ATOM   1841 O  OE2  . GLU A 1 119 ? 16.87807  13.43948  19.07114  1.000 29.49051  ? 111 GLU A OE2  1 
ATOM   1842 H  H    . GLU A 1 119 ? 12.39394  11.63594  16.64244  1.000 18.41536  ? 111 GLU A H    1 
ATOM   1843 H  HA   . GLU A 1 119 ? 13.99053  9.82477   17.81711  1.000 18.02164  ? 111 GLU A HA   1 
ATOM   1844 H  HB2  . GLU A 1 119 ? 13.15941  12.35633  18.71718  1.000 19.13300  ? 111 GLU A HB2  1 
ATOM   1845 H  HB3  . GLU A 1 119 ? 14.02190  11.37316  19.61990  1.000 19.13300  ? 111 GLU A HB3  1 
ATOM   1846 H  HG2  . GLU A 1 119 ? 15.76358  11.52359  18.09799  1.000 26.67021  ? 111 GLU A HG2  1 
ATOM   1847 H  HG3  . GLU A 1 119 ? 14.90254  12.53524  17.22587  1.000 26.67021  ? 111 GLU A HG3  1 
ATOM   1848 N  N    . MET A 1 120 ? 11.04910  9.44127   18.14803  1.000 19.24492  ? 112 MET A N    1 
ATOM   1849 C  CA   . MET A 1 120 ? 9.91483   8.84537   18.83480  1.000 14.63946  ? 112 MET A CA   1 
ATOM   1850 C  C    . MET A 1 120 ? 9.33432   7.73706   17.96996  1.000 14.55327  ? 112 MET A C    1 
ATOM   1851 O  O    . MET A 1 120 ? 9.43781   7.77918   16.74446  1.000 13.22921  ? 112 MET A O    1 
ATOM   1852 C  CB   . MET A 1 120 ? 8.82005   9.89252   19.11219  1.000 18.74030  ? 112 MET A CB   1 
ATOM   1853 C  CG   . MET A 1 120 ? 9.22948   10.97993  20.07205  1.000 26.67904  ? 112 MET A CG   1 
ATOM   1854 S  SD   . MET A 1 120 ? 7.87171   12.10692  20.50039  1.000 31.36225  ? 112 MET A SD   1 
ATOM   1855 C  CE   . MET A 1 120 ? 6.89873   12.13028  19.01238  1.000 21.16415  ? 112 MET A CE   1 
ATOM   1856 H  H    . MET A 1 120 ? 10.91786  9.54839   17.30488  1.000 23.07071  ? 112 MET A H    1 
ATOM   1857 H  HA   . MET A 1 120 ? 10.21161  8.47311   19.67993  1.000 17.54416  ? 112 MET A HA   1 
ATOM   1858 H  HB2  . MET A 1 120 ? 8.57782   10.31654  18.27407  1.000 22.46517  ? 112 MET A HB2  1 
ATOM   1859 H  HB3  . MET A 1 120 ? 8.04920   9.44157   19.49079  1.000 22.46517  ? 112 MET A HB3  1 
ATOM   1860 H  HG2  . MET A 1 120 ? 9.54752   10.57147  20.89236  1.000 31.99165  ? 112 MET A HG2  1 
ATOM   1861 H  HG3  . MET A 1 120 ? 9.93686   11.50608  19.66748  1.000 31.99165  ? 112 MET A HG3  1 
ATOM   1862 H  HE1  . MET A 1 120 ? 6.19648   12.79303  19.10462  1.000 25.37379  ? 112 MET A HE1  1 
ATOM   1863 H  HE2  . MET A 1 120 ? 7.47202   12.35782  18.26374  1.000 25.37379  ? 112 MET A HE2  1 
ATOM   1864 H  HE3  . MET A 1 120 ? 6.50926   11.25245  18.87591  1.000 25.37379  ? 112 MET A HE3  1 
ATOM   1865 N  N    . ILE A 1 121 ? 8.70076   6.75828   18.62201  1.000 17.08949  ? 113 ILE A N    1 
ATOM   1866 C  CA   . ILE A 1 121 ? 7.91346   5.72169   17.96570  1.000 15.38879  ? 113 ILE A CA   1 
ATOM   1867 C  C    . ILE A 1 121 ? 6.61018   5.58136   18.74239  1.000 16.85793  ? 113 ILE A C    1 
ATOM   1868 O  O    . ILE A 1 121 ? 6.50973   5.97824   19.90600  1.000 16.20898  ? 113 ILE A O    1 
ATOM   1869 C  CB   . ILE A 1 121 ? 8.65649   4.36685   17.87846  1.000 13.07983  ? 113 ILE A CB   1 
ATOM   1870 C  CG1  . ILE A 1 121 ? 8.97784   3.82780   19.26523  1.000 12.09249  ? 113 ILE A CG1  1 
ATOM   1871 C  CG2  . ILE A 1 121 ? 9.93064   4.52312   17.02368  1.000 13.98041  ? 113 ILE A CG2  1 
ATOM   1872 C  CD1  . ILE A 1 121 ? 9.56986   2.41815   19.24402  1.000 19.02666  ? 113 ILE A CD1  1 
ATOM   1873 H  H    . ILE A 1 121 ? 8.71517   6.67388   19.47773  1.000 20.48420  ? 113 ILE A H    1 
ATOM   1874 H  HA   . ILE A 1 121 ? 7.71011   5.98900   17.05570  1.000 18.44336  ? 113 ILE A HA   1 
ATOM   1875 H  HB   . ILE A 1 121 ? 8.07415   3.72075   17.44912  1.000 15.67261  ? 113 ILE A HB   1 
ATOM   1876 H  HG12 . ILE A 1 121 ? 9.62301   4.41562   19.68848  1.000 14.48780  ? 113 ILE A HG12 1 
ATOM   1877 H  HG13 . ILE A 1 121 ? 8.16123   3.80021   19.78800  1.000 14.48780  ? 113 ILE A HG13 1 
ATOM   1878 H  HG21 . ILE A 1 121 ? 10.36024  3.65786   16.93609  1.000 16.75330  ? 113 ILE A HG21 1 
ATOM   1879 H  HG22 . ILE A 1 121 ? 9.68420   4.86021   16.14816  1.000 16.75330  ? 113 ILE A HG22 1 
ATOM   1880 H  HG23 . ILE A 1 121 ? 10.53019  5.14727   17.46170  1.000 16.75330  ? 113 ILE A HG23 1 
ATOM   1881 H  HD11 . ILE A 1 121 ? 9.67245   2.10495   20.15631  1.000 22.80881  ? 113 ILE A HD11 1 
ATOM   1882 H  HD12 . ILE A 1 121 ? 8.96984   1.83092   18.75818  1.000 22.80881  ? 113 ILE A HD12 1 
ATOM   1883 H  HD13 . ILE A 1 121 ? 10.43410  2.44517   18.80441  1.000 22.80881  ? 113 ILE A HD13 1 
ATOM   1884 N  N    . TYR A 1 122 ? 5.62729   4.94447   18.10189  1.000 14.00764  ? 114 TYR A N    1 
ATOM   1885 C  CA   . TYR A 1 122 ? 4.23881   4.96363   18.55456  1.000 14.45716  ? 114 TYR A CA   1 
ATOM   1886 C  C    . TYR A 1 122 ? 3.73286   3.53154   18.58599  1.000 15.54474  ? 114 TYR A C    1 
ATOM   1887 O  O    . TYR A 1 122 ? 3.64717   2.88144   17.54039  1.000 14.64296  ? 114 TYR A O    1 
ATOM   1888 C  CB   . TYR A 1 122 ? 3.37761   5.84276   17.63005  1.000 17.56257  ? 114 TYR A CB   1 
ATOM   1889 C  CG   . TYR A 1 122 ? 1.99733   6.19908   18.14784  1.000 18.29196  ? 114 TYR A CG   1 
ATOM   1890 C  CD1  . TYR A 1 122 ? 1.08407   5.21381   18.47405  1.000 22.95644  ? 114 TYR A CD1  1 
ATOM   1891 C  CD2  . TYR A 1 122 ? 1.59681   7.52799   18.27214  1.000 23.93194  ? 114 TYR A CD2  1 
ATOM   1892 C  CE1  . TYR A 1 122 ? -0.18567  5.54026   18.92575  1.000 22.09148  ? 114 TYR A CE1  1 
ATOM   1893 C  CE2  . TYR A 1 122 ? 0.34141   7.85512   18.71984  1.000 20.60918  ? 114 TYR A CE2  1 
ATOM   1894 C  CZ   . TYR A 1 122 ? -0.54242  6.85801   19.05465  1.000 19.68425  ? 114 TYR A CZ   1 
ATOM   1895 O  OH   . TYR A 1 122 ? -1.80332  7.18159   19.50096  1.000 18.83878  ? 114 TYR A OH   1 
ATOM   1896 H  H    . TYR A 1 122 ? 5.74528   4.48383   17.38531  1.000 16.78598  ? 114 TYR A H    1 
ATOM   1897 H  HA   . TYR A 1 122 ? 4.17920   5.32473   19.45287  1.000 17.32540  ? 114 TYR A HA   1 
ATOM   1898 H  HB2  . TYR A 1 122 ? 3.85022   6.67598   17.47743  1.000 21.05190  ? 114 TYR A HB2  1 
ATOM   1899 H  HB3  . TYR A 1 122 ? 3.25598   5.37181   16.79082  1.000 21.05190  ? 114 TYR A HB3  1 
ATOM   1900 H  HD1  . TYR A 1 122 ? 1.32468   4.31948   18.38937  1.000 27.52453  ? 114 TYR A HD1  1 
ATOM   1901 H  HD2  . TYR A 1 122 ? 2.19185   8.20644   18.04732  1.000 28.69514  ? 114 TYR A HD2  1 
ATOM   1902 H  HE1  . TYR A 1 122 ? -0.79233  4.86878   19.14021  1.000 26.48659  ? 114 TYR A HE1  1 
ATOM   1903 H  HE2  . TYR A 1 122 ? 0.09024   8.74730   18.79620  1.000 24.70783  ? 114 TYR A HE2  1 
ATOM   1904 H  HH   . TYR A 1 122 ? -2.26826  6.48618   19.57744  1.000 22.58334  ? 114 TYR A HH   1 
ATOM   1905 N  N    . VAL A 1 123 ? 3.39654   3.04799   19.78008  1.000 15.28700  ? 115 VAL A N    1 
ATOM   1906 C  CA   . VAL A 1 123 ? 2.89385   1.69503   19.98365  1.000 21.33322  ? 115 VAL A CA   1 
ATOM   1907 C  C    . VAL A 1 123 ? 1.37887   1.75859   20.05300  1.000 21.77478  ? 115 VAL A C    1 
ATOM   1908 O  O    . VAL A 1 123 ? 0.81429   2.48568   20.88232  1.000 17.62105  ? 115 VAL A O    1 
ATOM   1909 C  CB   . VAL A 1 123 ? 3.47738   1.07187   21.26027  1.000 16.81078  ? 115 VAL A CB   1 
ATOM   1910 C  CG1  . VAL A 1 123 ? 3.04012   -0.33515  21.41256  1.000 15.58784  ? 115 VAL A CG1  1 
ATOM   1911 C  CG2  . VAL A 1 123 ? 5.00609   1.15666   21.22730  1.000 19.12529  ? 115 VAL A CG2  1 
ATOM   1912 H  H    . VAL A 1 123 ? 3.45337   3.50066   20.50909  1.000 18.32121  ? 115 VAL A H    1 
ATOM   1913 H  HA   . VAL A 1 123 ? 3.14302   1.14128   19.22723  1.000 25.57668  ? 115 VAL A HA   1 
ATOM   1914 H  HB   . VAL A 1 123 ? 3.15148   1.56607   22.02868  1.000 20.14974  ? 115 VAL A HB   1 
ATOM   1915 H  HG11 . VAL A 1 123 ? 3.46282   -0.71383  22.19922  1.000 18.68221  ? 115 VAL A HG11 1 
ATOM   1916 H  HG12 . VAL A 1 123 ? 2.07553   -0.35704  21.51246  1.000 18.68221  ? 115 VAL A HG12 1 
ATOM   1917 H  HG13 . VAL A 1 123 ? 3.30236   -0.83452  20.62340  1.000 18.68221  ? 115 VAL A HG13 1 
ATOM   1918 H  HG21 . VAL A 1 123 ? 5.36260   0.74479   22.02990  1.000 22.92716  ? 115 VAL A HG21 1 
ATOM   1919 H  HG22 . VAL A 1 123 ? 5.33150   0.68833   20.44265  1.000 22.92716  ? 115 VAL A HG22 1 
ATOM   1920 H  HG23 . VAL A 1 123 ? 5.26989   2.08931   21.18895  1.000 22.92716  ? 115 VAL A HG23 1 
ATOM   1921 N  N    . GLY A 1 124 ? 0.71990   0.97876   19.20123  1.000 19.24075  ? 116 GLY A N    1 
ATOM   1922 C  CA   . GLY A 1 124 ? -0.72663  1.00127   19.15849  1.000 15.29468  ? 116 GLY A CA   1 
ATOM   1923 C  C    . GLY A 1 124 ? -1.26646  -0.19853  18.41656  1.000 17.03753  ? 116 GLY A C    1 
ATOM   1924 O  O    . GLY A 1 124 ? -0.51501  -1.01435  17.87308  1.000 16.80974  ? 116 GLY A O    1 
ATOM   1925 H  H    . GLY A 1 124 ? 1.08839   0.43539   18.64575  1.000 23.06571  ? 116 GLY A H    1 
ATOM   1926 H  HA2  . GLY A 1 124 ? -1.08035  0.99316   20.06166  1.000 18.33042  ? 116 GLY A HA2  1 
ATOM   1927 H  HA3  . GLY A 1 124 ? -1.02772  1.80617   18.70862  1.000 18.33042  ? 116 GLY A HA3  1 
ATOM   1928 N  N    . ARG A 1 125 ? -2.59760  -0.28242  18.38781  1.000 17.13275  ? 117 ARG A N    1 
ATOM   1929 C  CA   . ARG A 1 125 ? -3.27590  -1.41055  17.75567  1.000 20.77519  ? 117 ARG A CA   1 
ATOM   1930 C  C    . ARG A 1 125 ? -4.51568  -0.96820  16.98716  1.000 16.26741  ? 117 ARG A C    1 
ATOM   1931 O  O    . ARG A 1 125 ? -4.75159  -1.41799  15.86139  1.000 22.19472  ? 117 ARG A O    1 
ATOM   1932 C  CB   . ARG A 1 125 ? -3.66671  -2.46372  18.80003  1.000 17.00111  ? 117 ARG A CB   1 
ATOM   1933 C  CG   . ARG A 1 125 ? -4.52404  -3.62524  18.25571  1.000 20.35873  ? 117 ARG A CG   1 
ATOM   1934 C  CD   . ARG A 1 125 ? -3.86208  -4.32281  17.07108  1.000 18.24450  ? 117 ARG A CD   1 
ATOM   1935 N  NE   . ARG A 1 125 ? -4.70271  -5.38989  16.53927  1.000 19.75274  ? 117 ARG A NE   1 
ATOM   1936 C  CZ   . ARG A 1 125 ? -5.68220  -5.21037  15.65741  1.000 23.03853  ? 117 ARG A CZ   1 
ATOM   1937 N  NH1  . ARG A 1 125 ? -5.93791  -3.99402  15.19402  1.000 19.02307  ? 117 ARG A NH1  1 
ATOM   1938 N  NH2  . ARG A 1 125 ? -6.40443  -6.25023  15.23386  1.000 19.77069  ? 117 ARG A NH2  1 
ATOM   1939 H  H    . ARG A 1 125 ? -3.12904  0.30200   18.72786  1.000 20.53611  ? 117 ARG A H    1 
ATOM   1940 H  HA   . ARG A 1 125 ? -2.65898  -1.81119  17.12338  1.000 24.90704  ? 117 ARG A HA   1 
ATOM   1941 H  HB2  . ARG A 1 125 ? -2.85580  -2.84732  19.16904  1.000 20.37815  ? 117 ARG A HB2  1 
ATOM   1942 H  HB3  . ARG A 1 125 ? -4.17644  -2.02810  19.50097  1.000 20.37815  ? 117 ARG A HB3  1 
ATOM   1943 H  HG2  . ARG A 1 125 ? -4.65485  -4.28134  18.95808  1.000 24.40728  ? 117 ARG A HG2  1 
ATOM   1944 H  HG3  . ARG A 1 125 ? -5.38096  -3.27852  17.96182  1.000 24.40728  ? 117 ARG A HG3  1 
ATOM   1945 H  HD2  . ARG A 1 125 ? -3.70615  -3.67678  16.36452  1.000 21.87021  ? 117 ARG A HD2  1 
ATOM   1946 H  HD3  . ARG A 1 125 ? -3.02056  -4.71147  17.35689  1.000 21.87021  ? 117 ARG A HD3  1 
ATOM   1947 H  HE   . ARG A 1 125 ? -4.55467  -6.19087  16.81515  1.000 23.68010  ? 117 ARG A HE   1 
ATOM   1948 H  HH11 . ARG A 1 125 ? -5.47095  -3.32412  15.46381  1.000 22.80450  ? 117 ARG A HH11 1 
ATOM   1949 H  HH12 . ARG A 1 125 ? -6.57066  -3.87533  14.62380  1.000 22.80450  ? 117 ARG A HH12 1 
ATOM   1950 H  HH21 . ARG A 1 125 ? -6.23710  -7.03963  15.53124  1.000 23.70163  ? 117 ARG A HH21 1 
ATOM   1951 H  HH22 . ARG A 1 125 ? -7.03700  -6.13067  14.66364  1.000 23.70163  ? 117 ARG A HH22 1 
ATOM   1952 N  N    . SER A 1 126 ? -5.31458  -0.08924  17.57926  1.000 18.05032  ? 118 SER A N    1 
ATOM   1953 C  CA   . SER A 1 126 ? -6.53133  0.35370   16.91658  1.000 23.69767  ? 118 SER A CA   1 
ATOM   1954 C  C    . SER A 1 126 ? -6.21760  1.13023   15.64161  1.000 21.09443  ? 118 SER A C    1 
ATOM   1955 O  O    . SER A 1 126 ? -5.16337  1.76056   15.50071  1.000 19.48284  ? 118 SER A O    1 
ATOM   1956 C  CB   . SER A 1 126 ? -7.36978  1.23065   17.84851  1.000 18.55640  ? 118 SER A CB   1 
ATOM   1957 O  OG   . SER A 1 126 ? -6.70591  2.44861   18.10490  1.000 22.18871  ? 118 SER A OG   1 
ATOM   1958 H  H    . SER A 1 126 ? -5.17631  0.26020   18.35281  1.000 21.63719  ? 118 SER A H    1 
ATOM   1959 H  HA   . SER A 1 126 ? -7.05238  -0.42875  16.67747  1.000 28.41401  ? 118 SER A HA   1 
ATOM   1960 H  HB2  . SER A 1 126 ? -8.22341  1.41666   17.42707  1.000 22.24450  ? 118 SER A HB2  1 
ATOM   1961 H  HB3  . SER A 1 126 ? -7.50856  0.76193   18.68633  1.000 22.24450  ? 118 SER A HB3  1 
ATOM   1962 H  HG   . SER A 1 126 ? -6.10424  2.33246   18.67945  1.000 26.60326  ? 118 SER A HG   1 
ATOM   1963 N  N    . GLN A 1 127 ? -7.17708  1.11792   14.71767  1.000 21.52419  ? 119 GLN A N    1 
ATOM   1964 C  CA   . GLN A 1 127 ? -7.02550  1.92523   13.51397  1.000 25.89576  ? 119 GLN A CA   1 
ATOM   1965 C  C    . GLN A 1 127 ? -6.90159  3.40726   13.84408  1.000 22.19435  ? 119 GLN A C    1 
ATOM   1966 O  O    . GLN A 1 127 ? -6.22228  4.14694   13.12269  1.000 23.23507  ? 119 GLN A O    1 
ATOM   1967 C  CB   . GLN A 1 127 ? -8.20286  1.69214   12.57140  1.000 28.01284  ? 119 GLN A CB   1 
ATOM   1968 C  CG   . GLN A 1 127 ? -8.33022  0.24033   12.10844  1.000 31.93534  ? 119 GLN A CG   1 
ATOM   1969 C  CD   . GLN A 1 127 ? -7.03859  -0.31607  11.50634  1.000 40.34578  ? 119 GLN A CD   1 
ATOM   1970 O  OE1  . GLN A 1 127 ? -6.52892  0.20389   10.51040  1.000 44.88315  ? 119 GLN A OE1  1 
ATOM   1971 N  NE2  . GLN A 1 127 ? -6.50694  -1.37728  12.11255  1.000 32.54358  ? 119 GLN A NE2  1 
ATOM   1972 H  H    . GLN A 1 127 ? -7.90536  0.66281   14.76340  1.000 25.80584  ? 119 GLN A H    1 
ATOM   1973 H  HA   . GLN A 1 127 ? -6.21565  1.64957   13.05675  1.000 31.05172  ? 119 GLN A HA   1 
ATOM   1974 H  HB2  . GLN A 1 127 ? -9.02347  1.93173   13.02978  1.000 33.59222  ? 119 GLN A HB2  1 
ATOM   1975 H  HB3  . GLN A 1 127 ? -8.08854  2.24697   11.78401  1.000 33.59222  ? 119 GLN A HB3  1 
ATOM   1976 H  HG2  . GLN A 1 127 ? -8.56667  -0.31270  12.86946  1.000 38.29922  ? 119 GLN A HG2  1 
ATOM   1977 H  HG3  . GLN A 1 127 ? -9.02237  0.18598   11.43103  1.000 38.29922  ? 119 GLN A HG3  1 
ATOM   1978 H  HE21 . GLN A 1 127 ? -6.88990  -1.71343  12.80534  1.000 39.02911  ? 119 GLN A HE21 1 
ATOM   1979 H  HE22 . GLN A 1 127 ? -5.78093  -1.72590  11.81094  1.000 39.02911  ? 119 GLN A HE22 1 
ATOM   1980 N  N    . GLU A 1 128 ? -7.56207  3.86100   14.91425  1.000 23.76389  ? 120 GLU A N    1 
ATOM   1981 C  CA   . GLU A 1 128 ? -7.43397  5.25318   15.33737  1.000 23.99477  ? 120 GLU A CA   1 
ATOM   1982 C  C    . GLU A 1 128 ? -5.98806  5.58594   15.68421  1.000 21.29730  ? 120 GLU A C    1 
ATOM   1983 O  O    . GLU A 1 128 ? -5.47938  6.65591   15.33020  1.000 20.95146  ? 120 GLU A O    1 
ATOM   1984 C  CB   . GLU A 1 128 ? -8.34272  5.52415   16.54071  1.000 25.64155  ? 120 GLU A CB   1 
ATOM   1985 C  CG   . GLU A 1 128 ? -9.82252  5.61033   16.21098  1.000 28.81067  ? 120 GLU A CG   1 
ATOM   1986 C  CD   . GLU A 1 128 ? -10.42050 4.25787   15.80319  1.000 31.90787  ? 120 GLU A CD   1 
ATOM   1987 O  OE1  . GLU A 1 128 ? -9.84588  3.20083   16.15754  1.000 28.42956  ? 120 GLU A OE1  1 
ATOM   1988 O  OE2  . GLU A 1 128 ? -11.46812 4.24896   15.12115  1.000 43.15786  ? 120 GLU A OE2  1 
ATOM   1989 H  H    . GLU A 1 128 ? -8.08461  3.38693   15.40599  1.000 28.49348  ? 120 GLU A H    1 
ATOM   1990 H  HA   . GLU A 1 128 ? -7.71642  5.82888   14.60957  1.000 28.77053  ? 120 GLU A HA   1 
ATOM   1991 H  HB2  . GLU A 1 128 ? -8.22759  4.80546   17.18191  1.000 30.74667  ? 120 GLU A HB2  1 
ATOM   1992 H  HB3  . GLU A 1 128 ? -8.08247  6.36928   16.93937  1.000 30.74667  ? 120 GLU A HB3  1 
ATOM   1993 H  HG2  . GLU A 1 128 ? -10.30237 5.92688   16.99229  1.000 34.54962  ? 120 GLU A HG2  1 
ATOM   1994 H  HG3  . GLU A 1 128 ? -9.94633  6.22755   15.47300  1.000 34.54962  ? 120 GLU A HG3  1 
ATOM   1995 N  N    . ASP A 1 129 ? -5.30966  4.68116   16.38369  1.000 20.37325  ? 121 ASP A N    1 
ATOM   1996 C  CA   . ASP A 1 129 ? -3.91628  4.91355   16.74172  1.000 16.87359  ? 121 ASP A CA   1 
ATOM   1997 C  C    . ASP A 1 129 ? -2.97679  4.70509   15.56396  1.000 18.64676  ? 121 ASP A C    1 
ATOM   1998 O  O    . ASP A 1 129 ? -1.96295  5.40611   15.45251  1.000 19.61353  ? 121 ASP A O    1 
ATOM   1999 C  CB   . ASP A 1 129 ? -3.53160  4.00202   17.90117  1.000 20.04660  ? 121 ASP A CB   1 
ATOM   2000 C  CG   . ASP A 1 129 ? -4.15057  4.45109   19.21906  1.000 18.58953  ? 121 ASP A CG   1 
ATOM   2001 O  OD1  . ASP A 1 129 ? -3.86360  5.58569   19.64749  1.000 15.13794  ? 121 ASP A OD1  1 
ATOM   2002 O  OD2  . ASP A 1 129 ? -4.92477  3.67813   19.82297  1.000 16.16008  ? 121 ASP A OD2  1 
ATOM   2003 H  H    . ASP A 1 129 ? -5.62992  3.93241   16.66012  1.000 24.42471  ? 121 ASP A H    1 
ATOM   2004 H  HA   . ASP A 1 129 ? -3.81117  5.83278   17.03304  1.000 20.22512  ? 121 ASP A HA   1 
ATOM   2005 H  HB2  . ASP A 1 129 ? -3.84038  3.10177   17.71381  1.000 24.03274  ? 121 ASP A HB2  1 
ATOM   2006 H  HB3  . ASP A 1 129 ? -2.56701  4.00738   18.00329  1.000 24.03274  ? 121 ASP A HB3  1 
ATOM   2007 N  N    . LEU A 1 130 ? -3.29710  3.77175   14.67130  1.000 15.95047  ? 122 LEU A N    1 
ATOM   2008 C  CA   . LEU A 1 130 ? -2.53035  3.66025   13.43617  1.000 15.32903  ? 122 LEU A CA   1 
ATOM   2009 C  C    . LEU A 1 130 ? -2.56900  4.96950   12.65286  1.000 19.10327  ? 122 LEU A C    1 
ATOM   2010 O  O    . LEU A 1 130 ? -1.53686  5.44862   12.16894  1.000 16.84795  ? 122 LEU A O    1 
ATOM   2011 C  CB   . LEU A 1 130 ? -3.06959  2.50411   12.59958  1.000 23.14473  ? 122 LEU A CB   1 
ATOM   2012 C  CG   . LEU A 1 130 ? -2.56347  2.37747   11.15655  1.000 27.80659  ? 122 LEU A CG   1 
ATOM   2013 C  CD1  . LEU A 1 130 ? -1.05252  2.25713   11.10204  1.000 23.30686  ? 122 LEU A CD1  1 
ATOM   2014 C  CD2  . LEU A 1 130 ? -3.21344  1.16115   10.49518  1.000 31.31650  ? 122 LEU A CD2  1 
ATOM   2015 H  H    . LEU A 1 130 ? -3.93815  3.20456   14.75462  1.000 19.11738  ? 122 LEU A H    1 
ATOM   2016 H  HA   . LEU A 1 130 ? -1.60328  3.46754   13.64662  1.000 18.37164  ? 122 LEU A HA   1 
ATOM   2017 H  HB2  . LEU A 1 130 ? -2.83818  1.67774   13.05176  1.000 27.75049  ? 122 LEU A HB2  1 
ATOM   2018 H  HB3  . LEU A 1 130 ? -4.03391  2.59729   12.55169  1.000 27.75049  ? 122 LEU A HB3  1 
ATOM   2019 H  HG   . LEU A 1 130 ? -2.80490  3.17995   10.66804  1.000 33.34472  ? 122 LEU A HG   1 
ATOM   2020 H  HD11 . LEU A 1 130 ? -0.77090  2.23315   10.17413  1.000 27.94504  ? 122 LEU A HD11 1 
ATOM   2021 H  HD12 . LEU A 1 130 ? -0.65842  3.02331   11.54763  1.000 27.94504  ? 122 LEU A HD12 1 
ATOM   2022 H  HD13 . LEU A 1 130 ? -0.78444  1.43977   11.55031  1.000 27.94504  ? 122 LEU A HD13 1 
ATOM   2023 H  HD21 . LEU A 1 130 ? -2.87815  1.07771   9.58881   1.000 37.55661  ? 122 LEU A HD21 1 
ATOM   2024 H  HD22 . LEU A 1 130 ? -2.98942  0.36703   11.00517  1.000 37.55661  ? 122 LEU A HD22 1 
ATOM   2025 H  HD23 . LEU A 1 130 ? -4.17538  1.28530   10.48190  1.000 37.55661  ? 122 LEU A HD23 1 
ATOM   2026 N  N    . GLN A 1 131 ? -3.74532  5.58085   12.54525  1.000 19.31884  ? 123 GLN A N    1 
ATOM   2027 C  CA   . GLN A 1 131 ? -3.84135  6.88824   11.91172  1.000 17.00410  ? 123 GLN A CA   1 
ATOM   2028 C  C    . GLN A 1 131 ? -3.03593  7.92806   12.67712  1.000 17.63515  ? 123 GLN A C    1 
ATOM   2029 O  O    . GLN A 1 131 ? -2.28308  8.70567   12.08533  1.000 20.28483  ? 123 GLN A O    1 
ATOM   2030 C  CB   . GLN A 1 131 ? -5.30080  7.30569   11.83479  1.000 20.13294  ? 123 GLN A CB   1 
ATOM   2031 C  CG   . GLN A 1 131 ? -6.13082  6.53380   10.86123  1.000 28.72443  ? 123 GLN A CG   1 
ATOM   2032 C  CD   . GLN A 1 131 ? -7.57518  7.03539   10.83617  1.000 46.80754  ? 123 GLN A CD   1 
ATOM   2033 O  OE1  . GLN A 1 131 ? -7.83110  8.24736   10.84483  1.000 48.14009  ? 123 GLN A OE1  1 
ATOM   2034 N  NE2  . GLN A 1 131 ? -8.52447  6.10314   10.80519  1.000 37.90265  ? 123 GLN A NE2  1 
ATOM   2035 H  H    . GLN A 1 131 ? -4.49304  5.26339   12.82763  1.000 23.15942  ? 123 GLN A H    1 
ATOM   2036 H  HA   . GLN A 1 131 ? -3.48402  6.83135   11.01174  1.000 20.38172  ? 123 GLN A HA   1 
ATOM   2037 H  HB2  . GLN A 1 131 ? -5.69925  7.19023   12.71160  1.000 24.13634  ? 123 GLN A HB2  1 
ATOM   2038 H  HB3  . GLN A 1 131 ? -5.33926  8.23896   11.57319  1.000 24.13634  ? 123 GLN A HB3  1 
ATOM   2039 H  HG2  . GLN A 1 131 ? -5.75755  6.63317   9.97146   1.000 34.44613  ? 123 GLN A HG2  1 
ATOM   2040 H  HG3  . GLN A 1 131 ? -6.13695  5.59783   11.11580  1.000 34.44613  ? 123 GLN A HG3  1 
ATOM   2041 H  HE21 . GLN A 1 131 ? -8.30943  5.27048   10.80020  1.000 45.45999  ? 123 GLN A HE21 1 
ATOM   2042 H  HE22 . GLN A 1 131 ? -9.35294  6.33339   10.79016  1.000 45.45999  ? 123 GLN A HE22 1 
ATOM   2043 N  N    . ALA A 1 132 ? -3.17922  7.95350   14.00235  1.000 19.61298  ? 124 ALA A N    1 
ATOM   2044 C  CA   . ALA A 1 132 ? -2.50759  8.98032   14.79015  1.000 19.37816  ? 124 ALA A CA   1 
ATOM   2045 C  C    . ALA A 1 132 ? -0.99943  8.94115   14.58534  1.000 18.63533  ? 124 ALA A C    1 
ATOM   2046 O  O    . ALA A 1 132 ? -0.35205  9.99015   14.51966  1.000 19.07408  ? 124 ALA A O    1 
ATOM   2047 C  CB   . ALA A 1 132 ? -2.84213  8.81376   16.27089  1.000 18.44247  ? 124 ALA A CB   1 
ATOM   2048 H  H    . ALA A 1 132 ? -3.65065  7.39815   14.45946  1.000 23.51239  ? 124 ALA A H    1 
ATOM   2049 H  HA   . ALA A 1 132 ? -2.83085  9.84795   14.50098  1.000 23.23060  ? 124 ALA A HA   1 
ATOM   2050 H  HB1  . ALA A 1 132 ? -2.38189  9.50082   16.77786  1.000 22.10777  ? 124 ALA A HB1  1 
ATOM   2051 H  HB2  . ALA A 1 132 ? -3.80083  8.90120   16.38983  1.000 22.10777  ? 124 ALA A HB2  1 
ATOM   2052 H  HB3  . ALA A 1 132 ? -2.55121  7.93592   16.56357  1.000 22.10777  ? 124 ALA A HB3  1 
ATOM   2053 N  N    . ALA A 1 133 ? -0.41846  7.74081   14.48403  1.000 21.37303  ? 125 ALA A N    1 
ATOM   2054 C  CA   . ALA A 1 133 ? 1.02916   7.63271   14.30986  1.000 22.32471  ? 125 ALA A CA   1 
ATOM   2055 C  C    . ALA A 1 133 ? 1.45367   7.94245   12.87835  1.000 20.89456  ? 125 ALA A C    1 
ATOM   2056 O  O    . ALA A 1 133 ? 2.44910   8.64313   12.65824  1.000 19.59044  ? 125 ALA A O    1 
ATOM   2057 C  CB   . ALA A 1 133 ? 1.51371   6.23139   14.69077  1.000 26.59818  ? 125 ALA A CB   1 
ATOM   2058 H  H    . ALA A 1 133 ? -0.83400  6.98841   14.51276  1.000 25.62445  ? 125 ALA A H    1 
ATOM   2059 H  HA   . ALA A 1 133 ? 1.44814   8.27500   14.90385  1.000 26.76646  ? 125 ALA A HA   1 
ATOM   2060 H  HB1  . ALA A 1 133 ? 2.48087   6.20226   14.62252  1.000 31.89463  ? 125 ALA A HB1  1 
ATOM   2061 H  HB2  . ALA A 1 133 ? 1.24045   6.03945   15.60148  1.000 31.89463  ? 125 ALA A HB2  1 
ATOM   2062 H  HB3  . ALA A 1 133 ? 1.11968   5.58522   14.08405  1.000 31.89463  ? 125 ALA A HB3  1 
ATOM   2063 N  N    . THR A 1 134 ? 0.72426   7.41299   11.89502  1.000 16.75194  ? 126 THR A N    1 
ATOM   2064 C  CA   . THR A 1 134 ? 1.10444   7.59522   10.49946  1.000 19.39621  ? 126 THR A CA   1 
ATOM   2065 C  C    . THR A 1 134 ? 0.75426   8.99422   10.00076  1.000 23.56405  ? 126 THR A C    1 
ATOM   2066 O  O    . THR A 1 134 ? 1.53956   9.60732   9.26633   1.000 17.81575  ? 126 THR A O    1 
ATOM   2067 C  CB   . THR A 1 134 ? 0.43208   6.52635   9.63263   1.000 19.92987  ? 126 THR A CB   1 
ATOM   2068 O  OG1  . THR A 1 134 ? -0.99076  6.53186   9.83823   1.000 18.45586  ? 126 THR A OG1  1 
ATOM   2069 C  CG2  . THR A 1 134 ? 0.97301   5.15035   9.99007   1.000 17.51073  ? 126 THR A CG2  1 
ATOM   2070 H  H    . THR A 1 134 ? 0.01028   6.94768   12.01045  1.000 20.07914  ? 126 THR A H    1 
ATOM   2071 H  HA   . THR A 1 134 ? 2.06463   7.48492   10.41718  1.000 23.25226  ? 126 THR A HA   1 
ATOM   2072 H  HB   . THR A 1 134 ? 0.61753   6.71406   8.69921   1.000 23.89265  ? 126 THR A HB   1 
ATOM   2073 H  HG1  . THR A 1 134 ? -1.18475  6.07639   10.51684  1.000 22.12384  ? 126 THR A HG1  1 
ATOM   2074 H  HG21 . THR A 1 134 ? 0.53507   4.47186   9.45270   1.000 20.98969  ? 126 THR A HG21 1 
ATOM   2075 H  HG22 . THR A 1 134 ? 1.92800   5.11579   9.82364   1.000 20.98969  ? 126 THR A HG22 1 
ATOM   2076 H  HG23 . THR A 1 134 ? 0.80989   4.96305   10.92773  1.000 20.98969  ? 126 THR A HG23 1 
ATOM   2077 N  N    . ASN A 1 135 ? -0.41599  9.52080   10.38635  1.000 21.11341  ? 127 ASN A N    1 
ATOM   2078 C  CA   . ASN A 1 135 ? -0.72466  10.91333  10.05503  1.000 25.43397  ? 127 ASN A CA   1 
ATOM   2079 C  C    . ASN A 1 135 ? 0.29936   11.85539  10.68062  1.000 24.61966  ? 127 ASN A C    1 
ATOM   2080 O  O    . ASN A 1 135 ? 0.56508   12.94067  10.15188  1.000 18.86627  ? 127 ASN A O    1 
ATOM   2081 C  CB   . ASN A 1 135 ? -2.13282  11.29550  10.52438  1.000 20.00513  ? 127 ASN A CB   1 
ATOM   2082 C  CG   . ASN A 1 135 ? -3.22649  10.71564  9.64669   1.000 22.12950  ? 127 ASN A CG   1 
ATOM   2083 O  OD1  . ASN A 1 135 ? -4.36893  10.51345  10.07561  1.000 33.85765  ? 127 ASN A OD1  1 
ATOM   2084 N  ND2  . ASN A 1 135 ? -2.88740  10.45074  8.40713   1.000 23.13601  ? 127 ASN A ND2  1 
ATOM   2085 H  H    . ASN A 1 135 ? -1.02717  9.10538   10.82621  1.000 25.31291  ? 127 ASN A H    1 
ATOM   2086 H  HA   . ASN A 1 135 ? -0.70520  11.00997  9.09006   1.000 30.49757  ? 127 ASN A HA   1 
ATOM   2087 H  HB2  . ASN A 1 135 ? -2.26558  10.96379  11.42618  1.000 23.98297  ? 127 ASN A HB2  1 
ATOM   2088 H  HB3  . ASN A 1 135 ? -2.21863  12.26159  10.51026  1.000 23.98297  ? 127 ASN A HB3  1 
ATOM   2089 H  HD21 . ASN A 1 135 ? -2.08580  10.60728  8.13779   1.000 27.74002  ? 127 ASN A HD21 1 
ATOM   2090 H  HD22 . ASN A 1 135 ? -3.46674  10.12058  7.86403   1.000 27.74002  ? 127 ASN A HD22 1 
ATOM   2091 N  N    . GLY A 1 136 ? 0.90531   11.44410  11.78540  1.000 21.93240  ? 128 GLY A N    1 
ATOM   2092 C  CA   . GLY A 1 136 ? 1.99579   12.16249  12.41009  1.000 21.48471  ? 128 GLY A CA   1 
ATOM   2093 C  C    . GLY A 1 136 ? 3.36138   11.77547  11.89114  1.000 23.16606  ? 128 GLY A C    1 
ATOM   2094 O  O    . GLY A 1 136 ? 4.38125   12.24209  12.41323  1.000 22.50609  ? 128 GLY A O    1 
ATOM   2095 H  H    . GLY A 1 136 ? 0.69164   10.72415  12.20446  1.000 26.29569  ? 128 GLY A H    1 
ATOM   2096 H  HA2  . GLY A 1 136 ? 1.87487   13.11262  12.25674  1.000 25.75846  ? 128 GLY A HA2  1 
ATOM   2097 H  HA3  . GLY A 1 136 ? 1.97836   11.99196  13.36482  1.000 25.75846  ? 128 GLY A HA3  1 
ATOM   2098 N  N    . ASN A 1 137 ? 3.40661   10.92115  10.87375  1.000 17.12175  ? 129 ASN A N    1 
ATOM   2099 C  CA   . ASN A 1 137 ? 4.65966   10.44457  10.29989  1.000 18.64163  ? 129 ASN A CA   1 
ATOM   2100 C  C    . ASN A 1 137 ? 5.62623   9.94876   11.37305  1.000 19.57118  ? 129 ASN A C    1 
ATOM   2101 O  O    . ASN A 1 137 ? 6.82301   10.23645  11.34394  1.000 20.33623  ? 129 ASN A O    1 
ATOM   2102 C  CB   . ASN A 1 137 ? 5.29407   11.53719  9.44763   1.000 21.96862  ? 129 ASN A CB   1 
ATOM   2103 C  CG   . ASN A 1 137 ? 4.53133   11.76838  8.14664   1.000 25.75953  ? 129 ASN A CG   1 
ATOM   2104 O  OD1  . ASN A 1 137 ? 4.02848   12.85722  7.91018   1.000 30.16154  ? 129 ASN A OD1  1 
ATOM   2105 N  ND2  . ASN A 1 137 ? 4.44341   10.73495  7.29913   1.000 29.42736  ? 129 ASN A ND2  1 
ATOM   2106 H  H    . ASN A 1 137 ? 2.70919   10.59575  10.48991  1.000 20.52291  ? 129 ASN A H    1 
ATOM   2107 H  HA   . ASN A 1 137 ? 4.46714   9.68167   9.73260   1.000 22.34677  ? 129 ASN A HA   1 
ATOM   2108 H  HB2  . ASN A 1 137 ? 5.29849   12.36851  9.94743   1.000 26.33915  ? 129 ASN A HB2  1 
ATOM   2109 H  HB3  . ASN A 1 137 ? 6.20215   11.27963  9.22413   1.000 26.33915  ? 129 ASN A HB3  1 
ATOM   2110 H  HD21 . ASN A 1 137 ? 4.02197   10.82393  6.55478   1.000 35.28964  ? 129 ASN A HD21 1 
ATOM   2111 H  HD22 . ASN A 1 137 ? 4.80840   9.98242   7.49933   1.000 35.28964  ? 129 ASN A HD22 1 
ATOM   2112 N  N    . THR A 1 138 ? 5.09131   9.21805   12.34563  1.000 22.27213  ? 130 THR A N    1 
ATOM   2113 C  CA   . THR A 1 138 ? 5.87583   8.54118   13.36625  1.000 19.24288  ? 130 THR A CA   1 
ATOM   2114 C  C    . THR A 1 138 ? 5.73485   7.04430   13.15589  1.000 18.09461  ? 130 THR A C    1 
ATOM   2115 O  O    . THR A 1 138 ? 4.65436   6.56208   12.80023  1.000 18.57012  ? 130 THR A O    1 
ATOM   2116 C  CB   . THR A 1 138 ? 5.40939   8.92254   14.77107  1.000 28.28506  ? 130 THR A CB   1 
ATOM   2117 O  OG1  . THR A 1 138 ? 5.39310   10.34671  14.88526  1.000 26.21335  ? 130 THR A OG1  1 
ATOM   2118 C  CG2  . THR A 1 138 ? 6.35260   8.36513   15.82552  1.000 26.67228  ? 130 THR A CG2  1 
ATOM   2119 H  H    . THR A 1 138 ? 4.24479   9.09657   12.43648  1.000 26.70336  ? 130 THR A H    1 
ATOM   2120 H  HA   . THR A 1 138 ? 6.81083   8.78977   13.29629  1.000 23.06827  ? 130 THR A HA   1 
ATOM   2121 H  HB   . THR A 1 138 ? 4.52377   8.55825   14.92561  1.000 33.91888  ? 130 THR A HB   1 
ATOM   2122 H  HG1  . THR A 1 138 ? 5.42947   10.57051  15.69408  1.000 31.43283  ? 130 THR A HG1  1 
ATOM   2123 H  HG21 . THR A 1 138 ? 6.04193   8.60989   16.71122  1.000 31.98354  ? 130 THR A HG21 1 
ATOM   2124 H  HG22 . THR A 1 138 ? 6.38845   7.39797   15.76061  1.000 31.98354  ? 130 THR A HG22 1 
ATOM   2125 H  HG23 . THR A 1 138 ? 7.24478   8.72268   15.69489  1.000 31.98354  ? 130 THR A HG23 1 
ATOM   2126 N  N    . LEU A 1 139 ? 6.82888   6.31700   13.36896  1.000 18.38995  ? 131 LEU A N    1 
ATOM   2127 C  CA   . LEU A 1 139 ? 6.84436   4.88769   13.09757  1.000 16.75787  ? 131 LEU A CA   1 
ATOM   2128 C  C    . LEU A 1 139 ? 5.82729   4.17422   13.97416  1.000 13.43327  ? 131 LEU A C    1 
ATOM   2129 O  O    . LEU A 1 139 ? 5.83195   4.32298   15.19832  1.000 13.56494  ? 131 LEU A O    1 
ATOM   2130 C  CB   . LEU A 1 139 ? 8.24499   4.32728   13.33871  1.000 18.61589  ? 131 LEU A CB   1 
ATOM   2131 C  CG   . LEU A 1 139 ? 8.45881   2.84066   13.04933  1.000 19.34347  ? 131 LEU A CG   1 
ATOM   2132 C  CD1  . LEU A 1 139 ? 8.47854   2.55376   11.56786  1.000 23.08345  ? 131 LEU A CD1  1 
ATOM   2133 C  CD2  . LEU A 1 139 ? 9.76790   2.38582   13.68652  1.000 20.17155  ? 131 LEU A CD2  1 
ATOM   2134 H  H    . LEU A 1 139 ? 7.57212   6.62828   13.66946  1.000 22.04475  ? 131 LEU A H    1 
ATOM   2135 H  HA   . LEU A 1 139 ? 6.61032   4.72934   12.16965  1.000 20.08626  ? 131 LEU A HA   1 
ATOM   2136 H  HB2  . LEU A 1 139 ? 8.86340   4.81692   12.77416  1.000 22.31588  ? 131 LEU A HB2  1 
ATOM   2137 H  HB3  . LEU A 1 139 ? 8.46581   4.46803   14.27270  1.000 22.31588  ? 131 LEU A HB3  1 
ATOM   2138 H  HG   . LEU A 1 139 ? 7.71870   2.34035   13.42725  1.000 23.18898  ? 131 LEU A HG   1 
ATOM   2139 H  HD11 . LEU A 1 139 ? 8.60286   1.60136   11.43226  1.000 27.67695  ? 131 LEU A HD11 1 
ATOM   2140 H  HD12 . LEU A 1 139 ? 7.63521   2.83574   11.18032  1.000 27.67695  ? 131 LEU A HD12 1 
ATOM   2141 H  HD13 . LEU A 1 139 ? 9.20993   3.04406   11.16095  1.000 27.67695  ? 131 LEU A HD13 1 
ATOM   2142 H  HD21 . LEU A 1 139 ? 9.89918   1.44306   13.49982  1.000 24.18268  ? 131 LEU A HD21 1 
ATOM   2143 H  HD22 . LEU A 1 139 ? 10.49809  2.90222   13.31095  1.000 24.18268  ? 131 LEU A HD22 1 
ATOM   2144 H  HD23 . LEU A 1 139 ? 9.71952   2.52969   14.64458  1.000 24.18268  ? 131 LEU A HD23 1 
ATOM   2145 N  N    . PHE A 1 140 ? 4.96830   3.37977   13.34334  1.000 16.42077  ? 132 PHE A N    1 
ATOM   2146 C  CA   . PHE A 1 140 ? 3.93141   2.64264   14.04991  1.000 15.13485  ? 132 PHE A CA   1 
ATOM   2147 C  C    . PHE A 1 140 ? 4.45503   1.27897   14.47795  1.000 14.59339  ? 132 PHE A C    1 
ATOM   2148 O  O    . PHE A 1 140 ? 5.04622   0.56170   13.66893  1.000 17.06116  ? 132 PHE A O    1 
ATOM   2149 C  CB   . PHE A 1 140 ? 2.70180   2.44914   13.16904  1.000 15.46046  ? 132 PHE A CB   1 
ATOM   2150 C  CG   . PHE A 1 140 ? 1.52764   1.84107   13.89409  1.000 15.56996  ? 132 PHE A CG   1 
ATOM   2151 C  CD1  . PHE A 1 140 ? 1.01749   2.42545   15.04390  1.000 19.86273  ? 132 PHE A CD1  1 
ATOM   2152 C  CD2  . PHE A 1 140 ? 0.93319   0.69464   13.42848  1.000 21.70416  ? 132 PHE A CD2  1 
ATOM   2153 C  CE1  . PHE A 1 140 ? -0.05935  1.87421   15.71569  1.000 20.07974  ? 132 PHE A CE1  1 
ATOM   2154 C  CE2  . PHE A 1 140 ? -0.15098  0.14383   14.09587  1.000 21.00913  ? 132 PHE A CE2  1 
ATOM   2155 C  CZ   . PHE A 1 140 ? -0.64990  0.74159   15.23399  1.000 23.42101  ? 132 PHE A CZ   1 
ATOM   2156 H  H    . PHE A 1 140 ? 4.96713   3.25034   12.49313  1.000 19.68174  ? 132 PHE A H    1 
ATOM   2157 H  HA   . PHE A 1 140 ? 3.67852   3.14749   14.83862  1.000 18.13863  ? 132 PHE A HA   1 
ATOM   2158 H  HB2  . PHE A 1 140 ? 2.42378   3.31312   12.82677  1.000 18.52937  ? 132 PHE A HB2  1 
ATOM   2159 H  HB3  . PHE A 1 140 ? 2.93375   1.86015   12.43407  1.000 18.52937  ? 132 PHE A HB3  1 
ATOM   2160 H  HD1  . PHE A 1 140 ? 1.40739   3.20416   15.37023  1.000 23.81208  ? 132 PHE A HD1  1 
ATOM   2161 H  HD2  . PHE A 1 140 ? 1.25957   0.28442   12.66030  1.000 26.02180  ? 132 PHE A HD2  1 
ATOM   2162 H  HE1  . PHE A 1 140 ? -0.37946  2.27367   16.49213  1.000 24.07250  ? 132 PHE A HE1  1 
ATOM   2163 H  HE2  . PHE A 1 140 ? -0.54441  -0.63464  13.77324  1.000 25.18776  ? 132 PHE A HE2  1 
ATOM   2164 H  HZ   . PHE A 1 140 ? -1.38456  0.37519   15.67094  1.000 28.08203  ? 132 PHE A HZ   1 
ATOM   2165 N  N    . ILE A 1 141 ? 4.22001   0.92756   15.74153  1.000 16.25734  ? 133 ILE A N    1 
ATOM   2166 C  CA   . ILE A 1 141 ? 4.62649   -0.34109  16.34402  1.000 10.66413  ? 133 ILE A CA   1 
ATOM   2167 C  C    . ILE A 1 141 ? 3.33880   -1.08506  16.67561  1.000 17.68087  ? 133 ILE A C    1 
ATOM   2168 O  O    . ILE A 1 141 ? 2.71669   -0.84392  17.71966  1.000 17.86090  ? 133 ILE A O    1 
ATOM   2169 C  CB   . ILE A 1 141 ? 5.48596   -0.13636  17.59723  1.000 13.28649  ? 133 ILE A CB   1 
ATOM   2170 C  CG1  . ILE A 1 141 ? 6.70280   0.72991   17.27454  1.000 16.62979  ? 133 ILE A CG1  1 
ATOM   2171 C  CG2  . ILE A 1 141 ? 5.94379   -1.48429  18.17479  1.000 10.13209  ? 133 ILE A CG2  1 
ATOM   2172 C  CD1  . ILE A 1 141 ? 7.60626   0.13403   16.17269  1.000 21.01317  ? 133 ILE A CD1  1 
ATOM   2173 H  H    . ILE A 1 141 ? 3.80473   1.43456   16.29839  1.000 19.48561  ? 133 ILE A H    1 
ATOM   2174 H  HA   . ILE A 1 141 ? 5.13990   -0.85671  15.70258  1.000 12.77377  ? 133 ILE A HA   1 
ATOM   2175 H  HB   . ILE A 1 141 ? 4.94061   0.31662   18.25927  1.000 15.92060  ? 133 ILE A HB   1 
ATOM   2176 H  HG12 . ILE A 1 141 ? 6.39688   1.59881   16.97068  1.000 19.93256  ? 133 ILE A HG12 1 
ATOM   2177 H  HG13 . ILE A 1 141 ? 7.23846   0.82881   18.07715  1.000 19.93256  ? 133 ILE A HG13 1 
ATOM   2178 H  HG21 . ILE A 1 141 ? 6.47299   -1.32307  18.97156  1.000 12.13531  ? 133 ILE A HG21 1 
ATOM   2179 H  HG22 . ILE A 1 141 ? 5.16243   -2.01387  18.39821  1.000 12.13531  ? 133 ILE A HG22 1 
ATOM   2180 H  HG23 . ILE A 1 141 ? 6.47830   -1.94719  17.51076  1.000 12.13531  ? 133 ILE A HG23 1 
ATOM   2181 H  HD11 . ILE A 1 141 ? 8.35609   0.73069   16.02217  1.000 25.19261  ? 133 ILE A HD11 1 
ATOM   2182 H  HD12 . ILE A 1 141 ? 7.92738   -0.73408  16.46281  1.000 25.19261  ? 133 ILE A HD12 1 
ATOM   2183 H  HD13 . ILE A 1 141 ? 7.08952   0.03995   15.35720  1.000 25.19261  ? 133 ILE A HD13 1 
ATOM   2184 N  N    . ASN A 1 142 ? 2.92366   -1.97185  15.77407  1.000 14.28653  ? 134 ASN A N    1 
ATOM   2185 C  CA   . ASN A 1 142 ? 1.64185   -2.66419  15.87182  1.000 12.34413  ? 134 ASN A CA   1 
ATOM   2186 C  C    . ASN A 1 142 ? 1.71403   -3.74089  16.95088  1.000 16.93639  ? 134 ASN A C    1 
ATOM   2187 O  O    . ASN A 1 142 ? 2.34587   -4.79219  16.76444  1.000 12.57521  ? 134 ASN A O    1 
ATOM   2188 C  CB   . ASN A 1 142 ? 1.28766   -3.25463  14.51036  1.000 19.23402  ? 134 ASN A CB   1 
ATOM   2189 C  CG   . ASN A 1 142 ? -0.17253  -3.63467  14.38706  1.000 16.25283  ? 134 ASN A CG   1 
ATOM   2190 O  OD1  . ASN A 1 142 ? -0.97845  -3.37417  15.26742  1.000 21.13149  ? 134 ASN A OD1  1 
ATOM   2191 N  ND2  . ASN A 1 142 ? -0.51756  -4.24171  13.27439  1.000 18.05410  ? 134 ASN A ND2  1 
ATOM   2192 H  H    . ASN A 1 142 ? 3.37808   -2.19530  15.07897  1.000 17.12064  ? 134 ASN A H    1 
ATOM   2193 H  HA   . ASN A 1 142 ? 0.94946   -2.03940  16.13852  1.000 14.78976  ? 134 ASN A HA   1 
ATOM   2194 H  HB2  . ASN A 1 142 ? 1.48424   -2.59937  13.82268  1.000 23.05763  ? 134 ASN A HB2  1 
ATOM   2195 H  HB3  . ASN A 1 142 ? 1.81704   -4.05474  14.36726  1.000 23.05763  ? 134 ASN A HB3  1 
ATOM   2196 H  HD21 . ASN A 1 142 ? -1.33435  -4.48058  13.15034  1.000 21.64173  ? 134 ASN A HD21 1 
ATOM   2197 H  HD22 . ASN A 1 142 ? 0.07335   -4.40025  12.67000  1.000 21.64173  ? 134 ASN A HD22 1 
ATOM   2198 N  N    . ALA A 1 143 ? 1.04275   -3.48992  18.07268  1.000 16.99730  ? 135 ALA A N    1 
ATOM   2199 C  CA   . ALA A 1 143 ? 1.02855   -4.42167  19.19199  1.000 17.80562  ? 135 ALA A CA   1 
ATOM   2200 C  C    . ALA A 1 143 ? -0.16906  -5.35253  19.06554  1.000 14.77875  ? 135 ALA A C    1 
ATOM   2201 O  O    . ALA A 1 143 ? -1.31954  -4.90025  19.06688  1.000 17.99090  ? 135 ALA A O    1 
ATOM   2202 C  CB   . ALA A 1 143 ? 0.97883   -3.68340  20.52600  1.000 14.31977  ? 135 ALA A CB   1 
ATOM   2203 H  H    . ALA A 1 143 ? 0.58236   -2.77648  18.20919  1.000 20.37357  ? 135 ALA A H    1 
ATOM   2204 H  HA   . ALA A 1 143 ? 1.84140   -4.95029  19.16484  1.000 21.34355  ? 135 ALA A HA   1 
ATOM   2205 H  HB1  . ALA A 1 143 ? 0.94597   -4.33314  21.24548  1.000 17.16054  ? 135 ALA A HB1  1 
ATOM   2206 H  HB2  . ALA A 1 143 ? 1.77343   -3.13385  20.61262  1.000 17.16054  ? 135 ALA A HB2  1 
ATOM   2207 H  HB3  . ALA A 1 143 ? 0.18620   -3.12470  20.54839  1.000 17.16054  ? 135 ALA A HB3  1 
ATOM   2208 N  N    . THR A 1 144 ? 0.09727   -6.65431  18.99749  1.000 13.30598  ? 136 THR A N    1 
ATOM   2209 C  CA   . THR A 1 144 ? -0.92842  -7.63585  18.66416  1.000 15.63903  ? 136 THR A CA   1 
ATOM   2210 C  C    . THR A 1 144 ? -1.08266  -8.70746  19.74483  1.000 17.49552  ? 136 THR A C    1 
ATOM   2211 O  O    . THR A 1 144 ? -1.56185  -9.81224  19.47365  1.000 15.57006  ? 136 THR A O    1 
ATOM   2212 C  CB   . THR A 1 144 ? -0.62491  -8.28546  17.31198  1.000 18.38767  ? 136 THR A CB   1 
ATOM   2213 O  OG1  . THR A 1 144 ? 0.70107   -8.82174  17.32647  1.000 15.25584  ? 136 THR A OG1  1 
ATOM   2214 C  CG2  . THR A 1 144 ? -0.70994  -7.28630  16.19796  1.000 17.81409  ? 136 THR A CG2  1 
ATOM   2215 H  H    . THR A 1 144 ? 0.87330   -6.99562  19.14203  1.000 15.94398  ? 136 THR A H    1 
ATOM   2216 H  HA   . THR A 1 144 ? -1.77749  -7.17097  18.60194  1.000 18.74365  ? 136 THR A HA   1 
ATOM   2217 H  HB   . THR A 1 144 ? -1.27549  -8.98696  17.15216  1.000 22.04201  ? 136 THR A HB   1 
ATOM   2218 H  HG1  . THR A 1 144 ? 0.78873   -9.38788  16.71215  1.000 18.28382  ? 136 THR A HG1  1 
ATOM   2219 H  HG21 . THR A 1 144 ? -0.51286  -7.71613  15.35103  1.000 21.35372  ? 136 THR A HG21 1 
ATOM   2220 H  HG22 . THR A 1 144 ? -1.60233  -6.90811  16.15891  1.000 21.35372  ? 136 THR A HG22 1 
ATOM   2221 H  HG23 . THR A 1 144 ? -0.07111  -6.57118  16.34422  1.000 21.35372  ? 136 THR A HG23 1 
ATOM   2222 N  N    . TRP A 1 145 ? -0.76492  -8.39217  20.99097  1.000 16.83493  ? 137 TRP A N    1 
ATOM   2223 C  CA   . TRP A 1 145 ? -0.89677  -9.41562  22.02034  1.000 16.47370  ? 137 TRP A CA   1 
ATOM   2224 C  C    . TRP A 1 145 ? -2.32113  -9.56608  22.54344  1.000 17.22824  ? 137 TRP A C    1 
ATOM   2225 O  O    . TRP A 1 145 ? -2.63897  -10.60493 23.14040  1.000 17.74166  ? 137 TRP A O    1 
ATOM   2226 C  CB   . TRP A 1 145 ? 0.04850   -9.12911  23.18432  1.000 18.41246  ? 137 TRP A CB   1 
ATOM   2227 C  CG   . TRP A 1 145 ? 0.04533   -7.72521  23.73185  1.000 18.19241  ? 137 TRP A CG   1 
ATOM   2228 C  CD1  . TRP A 1 145 ? -0.88355  -7.16914  24.55368  1.000 18.77283  ? 137 TRP A CD1  1 
ATOM   2229 C  CD2  . TRP A 1 145 ? 1.04089   -6.71761  23.51275  1.000 17.20751  ? 137 TRP A CD2  1 
ATOM   2230 N  NE1  . TRP A 1 145 ? -0.52454  -5.88671  24.87581  1.000 15.47994  ? 137 TRP A NE1  1 
ATOM   2231 C  CE2  . TRP A 1 145 ? 0.64040   -5.57500  24.23190  1.000 14.06147  ? 137 TRP A CE2  1 
ATOM   2232 C  CE3  . TRP A 1 145 ? 2.21571   -6.66585  22.76150  1.000 15.57478  ? 137 TRP A CE3  1 
ATOM   2233 C  CZ2  . TRP A 1 145 ? 1.38190   -4.39919  24.24243  1.000 11.80826  ? 137 TRP A CZ2  1 
ATOM   2234 C  CZ3  . TRP A 1 145 ? 2.95497   -5.50144  22.76820  1.000 14.62565  ? 137 TRP A CZ3  1 
ATOM   2235 C  CH2  . TRP A 1 145 ? 2.53804   -4.37942  23.51396  1.000 19.14936  ? 137 TRP A CH2  1 
ATOM   2236 H  H    . TRP A 1 145 ? -0.48205  -7.62504  21.25763  1.000 20.17872  ? 137 TRP A H    1 
ATOM   2237 H  HA   . TRP A 1 145 ? -0.63835  -10.26516 21.62996  1.000 19.74525  ? 137 TRP A HA   1 
ATOM   2238 H  HB2  . TRP A 1 145 ? -0.18969  -9.71896  23.91661  1.000 22.07177  ? 137 TRP A HB2  1 
ATOM   2239 H  HB3  . TRP A 1 145 ? 0.95343   -9.31561  22.88899  1.000 22.07177  ? 137 TRP A HB3  1 
ATOM   2240 H  HD1  . TRP A 1 145 ? -1.65234  -7.59758  24.85418  1.000 22.50420  ? 137 TRP A HD1  1 
ATOM   2241 H  HE1  . TRP A 1 145 ? -0.96165  -5.36232  25.39883  1.000 18.55274  ? 137 TRP A HE1  1 
ATOM   2242 H  HE3  . TRP A 1 145 ? 2.49467   -7.40186  22.26616  1.000 18.66655  ? 137 TRP A HE3  1 
ATOM   2243 H  HZ2  . TRP A 1 145 ? 1.10233   -3.65560  24.72597  1.000 14.14672  ? 137 TRP A HZ2  1 
ATOM   2244 H  HZ3  . TRP A 1 145 ? 3.74086   -5.45550  22.27305  1.000 17.52760  ? 137 TRP A HZ3  1 
ATOM   2245 H  HH2  . TRP A 1 145 ? 3.06065   -3.61016  23.50995  1.000 22.95604  ? 137 TRP A HH2  1 
ATOM   2246 N  N    . TYR A 1 146 ? -3.17262  -8.55466  22.35854  1.000 21.49881  ? 138 TYR A N    1 
ATOM   2247 C  CA   . TYR A 1 146 ? -4.57460  -8.64343  22.74429  1.000 16.55652  ? 138 TYR A CA   1 
ATOM   2248 C  C    . TYR A 1 146 ? -5.48601  -8.88871  21.55376  1.000 20.71211  ? 138 TYR A C    1 
ATOM   2249 O  O    . TYR A 1 146 ? -6.47596  -9.61645  21.68777  1.000 19.49321  ? 138 TYR A O    1 
ATOM   2250 C  CB   . TYR A 1 146 ? -5.02729  -7.36819  23.47169  1.000 20.22781  ? 138 TYR A CB   1 
ATOM   2251 C  CG   . TYR A 1 146 ? -4.65298  -7.32462  24.93428  1.000 19.26198  ? 138 TYR A CG   1 
ATOM   2252 C  CD1  . TYR A 1 146 ? -4.87764  -8.41847  25.76362  1.000 20.94363  ? 138 TYR A CD1  1 
ATOM   2253 C  CD2  . TYR A 1 146 ? -4.06507  -6.18978  25.48681  1.000 19.55036  ? 138 TYR A CD2  1 
ATOM   2254 C  CE1  . TYR A 1 146 ? -4.53496  -8.38529  27.11043  1.000 21.07780  ? 138 TYR A CE1  1 
ATOM   2255 C  CE2  . TYR A 1 146 ? -3.72266  -6.14136  26.83649  1.000 20.36040  ? 138 TYR A CE2  1 
ATOM   2256 C  CZ   . TYR A 1 146 ? -3.94652  -7.25791  27.63666  1.000 19.93025  ? 138 TYR A CZ   1 
ATOM   2257 O  OH   . TYR A 1 146 ? -3.61703  -7.24882  28.97001  1.000 16.29311  ? 138 TYR A OH   1 
ATOM   2258 H  H    . TYR A 1 146 ? -2.95616  -7.80002  22.00744  1.000 25.77539  ? 138 TYR A H    1 
ATOM   2259 H  HA   . TYR A 1 146 ? -4.68091  -9.37644  23.37062  1.000 19.84463  ? 138 TYR A HA   1 
ATOM   2260 H  HB2  . TYR A 1 146 ? -4.61707  -6.60253  23.03996  1.000 24.25019  ? 138 TYR A HB2  1 
ATOM   2261 H  HB3  . TYR A 1 146 ? -5.99338  -7.30393  23.41308  1.000 24.25019  ? 138 TYR A HB3  1 
ATOM   2262 H  HD1  . TYR A 1 146 ? -5.26455  -9.18681  25.41028  1.000 25.10917  ? 138 TYR A HD1  1 
ATOM   2263 H  HD2  . TYR A 1 146 ? -3.89818  -5.45186  24.94596  1.000 23.43724  ? 138 TYR A HD2  1 
ATOM   2264 H  HE1  . TYR A 1 146 ? -4.70256  -9.12152  27.65337  1.000 25.27018  ? 138 TYR A HE1  1 
ATOM   2265 H  HE2  . TYR A 1 146 ? -3.34841  -5.37098  27.19894  1.000 24.40929  ? 138 TYR A HE2  1 
ATOM   2266 H  HH   . TYR A 1 146 ? -3.22568  -6.53142  29.16435  1.000 19.52855  ? 138 TYR A HH   1 
ATOM   2267 N  N    . GLU A 1 147 ? -5.16001  -8.32900  20.38806  1.000 16.16834  ? 139 GLU A N    1 
ATOM   2268 C  CA   . GLU A 1 147 ? -5.97926  -8.48494  19.18808  1.000 21.74421  ? 139 GLU A CA   1 
ATOM   2269 C  C    . GLU A 1 147 ? -5.08096  -8.84813  18.01612  1.000 23.01788  ? 139 GLU A C    1 
ATOM   2270 O  O    . GLU A 1 147 ? -4.22062  -8.02909  17.61783  1.000 20.35900  ? 139 GLU A O    1 
ATOM   2271 C  CB   . GLU A 1 147 ? -6.77407  -7.21269  18.88320  1.000 18.96603  ? 139 GLU A CB   1 
ATOM   2272 C  CG   . GLU A 1 147 ? -7.88979  -6.92287  19.87040  1.000 21.99997  ? 139 GLU A CG   1 
ATOM   2273 C  CD   . GLU A 1 147 ? -8.91748  -8.04849  19.95480  1.000 28.07304  ? 139 GLU A CD   1 
ATOM   2274 O  OE1  . GLU A 1 147 ? -9.12577  -8.73457  18.93130  1.000 28.93969  ? 139 GLU A OE1  1 
ATOM   2275 O  OE2  . GLU A 1 147 ? -9.51874  -8.24603  21.03872  1.000 29.55543  ? 139 GLU A OE2  1 
ATOM   2276 H  H    . GLU A 1 147 ? -4.45808  -7.84721  20.26653  1.000 19.37882  ? 139 GLU A H    1 
ATOM   2277 H  HA   . GLU A 1 147 ? -6.60266  -9.21354  19.33446  1.000 26.06986  ? 139 GLU A HA   1 
ATOM   2278 H  HB2  . GLU A 1 147 ? -6.16616  -6.45694  18.89641  1.000 22.73604  ? 139 GLU A HB2  1 
ATOM   2279 H  HB3  . GLU A 1 147 ? -7.17476  -7.30084  18.00424  1.000 22.73604  ? 139 GLU A HB3  1 
ATOM   2280 H  HG2  . GLU A 1 147 ? -7.50621  -6.80131  20.75300  1.000 26.37678  ? 139 GLU A HG2  1 
ATOM   2281 H  HG3  . GLU A 1 147 ? -8.35221  -6.11569  19.59558  1.000 26.37678  ? 139 GLU A HG3  1 
ATOM   2282 N  N    . PRO A 1 148 ? -5.23718  -10.03291 17.42267  1.000 21.55062  ? 140 PRO A N    1 
ATOM   2283 C  CA   . PRO A 1 148 ? -4.32306  -10.44702 16.34904  1.000 19.14442  ? 140 PRO A CA   1 
ATOM   2284 C  C    . PRO A 1 148 ? -4.52731  -9.61950  15.08782  1.000 18.17188  ? 140 PRO A C    1 
ATOM   2285 O  O    . PRO A 1 148 ? -5.51699  -8.89762  14.91770  1.000 18.65063  ? 140 PRO A O    1 
ATOM   2286 C  CB   . PRO A 1 148 ? -4.67056  -11.92108 16.11256  1.000 27.18739  ? 140 PRO A CB   1 
ATOM   2287 C  CG   . PRO A 1 148 ? -6.13279  -12.02318 16.54831  1.000 30.79331  ? 140 PRO A CG   1 
ATOM   2288 C  CD   . PRO A 1 148 ? -6.25358  -11.06599 17.72626  1.000 22.43370  ? 140 PRO A CD   1 
ATOM   2289 H  HA   . PRO A 1 148 ? -3.40175  -10.37425 16.64364  1.000 22.95012  ? 140 PRO A HA   1 
ATOM   2290 H  HB2  . PRO A 1 148 ? -4.56674  -12.14374 15.17419  1.000 32.60168  ? 140 PRO A HB2  1 
ATOM   2291 H  HB3  . PRO A 1 148 ? -4.10164  -12.49072 16.65361  1.000 32.60168  ? 140 PRO A HB3  1 
ATOM   2292 H  HG2  . PRO A 1 148 ? -6.71527  -11.75431 15.82076  1.000 36.92878  ? 140 PRO A HG2  1 
ATOM   2293 H  HG3  . PRO A 1 148 ? -6.33604  -12.93273 16.81721  1.000 36.92878  ? 140 PRO A HG3  1 
ATOM   2294 H  HD2  . PRO A 1 148 ? -7.14125  -10.67701 17.76667  1.000 26.89725  ? 140 PRO A HD2  1 
ATOM   2295 H  HD3  . PRO A 1 148 ? -6.05056  -11.51671 18.56084  1.000 26.89725  ? 140 PRO A HD3  1 
ATOM   2296 N  N    . VAL A 1 149 ? -3.54519  -9.73314  14.19484  1.000 15.96566  ? 141 VAL A N    1 
ATOM   2297 C  CA   . VAL A 1 149 ? -3.58707  -9.10958  12.87822  1.000 15.69014  ? 141 VAL A CA   1 
ATOM   2298 C  C    . VAL A 1 149 ? -3.08161  -10.12925 11.87224  1.000 19.71350  ? 141 VAL A C    1 
ATOM   2299 O  O    . VAL A 1 149 ? -1.99015  -10.68146 12.03567  1.000 19.13832  ? 141 VAL A O    1 
ATOM   2300 C  CB   . VAL A 1 149 ? -2.74002  -7.82353  12.80541  1.000 23.33278  ? 141 VAL A CB   1 
ATOM   2301 C  CG1  . VAL A 1 149 ? -2.65617  -7.32116  11.36924  1.000 24.38117  ? 141 VAL A CG1  1 
ATOM   2302 C  CG2  . VAL A 1 149 ? -3.32127  -6.74313  13.71365  1.000 19.84264  ? 141 VAL A CG2  1 
ATOM   2303 H  H    . VAL A 1 149 ? -2.82399  -10.18012 14.33508  1.000 19.13560  ? 141 VAL A H    1 
ATOM   2304 H  HA   . VAL A 1 149 ? -4.50315  -8.87282  12.66457  1.000 18.80498  ? 141 VAL A HA   1 
ATOM   2305 H  HB   . VAL A 1 149 ? -1.84209  -8.02537  13.11182  1.000 27.97614  ? 141 VAL A HB   1 
ATOM   2306 H  HG11 . VAL A 1 149 ? -2.18925  -6.47100  11.35882  1.000 29.23421  ? 141 VAL A HG11 1 
ATOM   2307 H  HG12 . VAL A 1 149 ? -2.17262  -7.97068  10.83520  1.000 29.23421  ? 141 VAL A HG12 1 
ATOM   2308 H  HG13 . VAL A 1 149 ? -3.55450  -7.20946  11.02079  1.000 29.23421  ? 141 VAL A HG13 1 
ATOM   2309 H  HG21 . VAL A 1 149 ? -2.76263  -5.95192  13.66073  1.000 23.78798  ? 141 VAL A HG21 1 
ATOM   2310 H  HG22 . VAL A 1 149 ? -4.22112  -6.53305  13.41861  1.000 23.78798  ? 141 VAL A HG22 1 
ATOM   2311 H  HG23 . VAL A 1 149 ? -3.34083  -7.07387  14.62531  1.000 23.78798  ? 141 VAL A HG23 1 
ATOM   2312 N  N    . THR A 1 150 ? -3.86129  -10.37033 10.82539  1.000 21.41394  ? 142 THR A N    1 
ATOM   2313 C  CA   . THR A 1 150 ? -3.49755  -11.36778 9.82708   1.000 30.22019  ? 142 THR A CA   1 
ATOM   2314 C  C    . THR A 1 150 ? -3.17697  -10.77068 8.46477   1.000 21.93419  ? 142 THR A C    1 
ATOM   2315 O  O    . THR A 1 150 ? -2.64783  -11.48651 7.60343   1.000 23.61461  ? 142 THR A O    1 
ATOM   2316 C  CB   . THR A 1 150 ? -4.62622  -12.39248 9.64852   1.000 17.05689  ? 142 THR A CB   1 
ATOM   2317 O  OG1  . THR A 1 150 ? -5.81142  -11.69450 9.26692   1.000 21.10503  ? 142 THR A OG1  1 
ATOM   2318 C  CG2  . THR A 1 150 ? -4.86782  -13.16494 10.92038  1.000 24.27701  ? 142 THR A CG2  1 
ATOM   2319 H  H    . THR A 1 150 ? -4.60619  -9.96918  10.67108  1.000 25.67354  ? 142 THR A H    1 
ATOM   2320 H  HA   . THR A 1 150 ? -2.71198  -11.83762 10.14803  1.000 36.24104  ? 142 THR A HA   1 
ATOM   2321 H  HB   . THR A 1 150 ? -4.38560  -13.03768 8.96535   1.000 20.44508  ? 142 THR A HB   1 
ATOM   2322 H  HG1  . THR A 1 150 ? -6.43680  -12.24000 9.13685   1.000 25.30284  ? 142 THR A HG1  1 
ATOM   2323 H  HG21 . THR A 1 150 ? -5.58135  -13.80841 10.78727  1.000 29.10922  ? 142 THR A HG21 1 
ATOM   2324 H  HG22 . THR A 1 150 ? -4.06159  -13.63800 11.17945  1.000 29.10922  ? 142 THR A HG22 1 
ATOM   2325 H  HG23 . THR A 1 150 ? -5.12001  -12.55839 11.63410  1.000 29.10922  ? 142 THR A HG23 1 
ATOM   2326 N  N    . GLU A 1 151 ? -3.47369  -9.48668  8.24991   1.000 21.64768  ? 143 GLU A N    1 
ATOM   2327 C  CA   . GLU A 1 151 ? -3.35761  -8.90012  6.92057   1.000 23.37803  ? 143 GLU A CA   1 
ATOM   2328 C  C    . GLU A 1 151 ? -1.90805  -8.61041  6.54210   1.000 30.05707  ? 143 GLU A C    1 
ATOM   2329 O  O    . GLU A 1 151 ? -1.52763  -8.79867  5.37836   1.000 24.89894  ? 143 GLU A O    1 
ATOM   2330 C  CB   . GLU A 1 151 ? -4.19178  -7.61958  6.84242   1.000 28.11579  ? 143 GLU A CB   1 
ATOM   2331 C  CG   . GLU A 1 151 ? -4.14114  -6.93376  5.48051   1.000 31.23237  ? 143 GLU A CG   1 
ATOM   2332 C  CD   . GLU A 1 151 ? -5.00185  -5.68171  5.42926   1.000 42.15801  ? 143 GLU A CD   1 
ATOM   2333 O  OE1  . GLU A 1 151 ? -5.88278  -5.51222  6.30935   1.000 39.24243  ? 143 GLU A OE1  1 
ATOM   2334 O  OE2  . GLU A 1 151 ? -4.79006  -4.86540  4.50775   1.000 44.43196  ? 143 GLU A OE2  1 
ATOM   2335 H  H    . GLU A 1 151 ? -3.74286  -8.93880  8.85570   1.000 25.95403  ? 143 GLU A H    1 
ATOM   2336 H  HA   . GLU A 1 151 ? -3.70713  -9.53438  6.27525   1.000 28.03045  ? 143 GLU A HA   1 
ATOM   2337 H  HB2  . GLU A 1 151 ? -5.11800  -7.83919  7.02890   1.000 33.71575  ? 143 GLU A HB2  1 
ATOM   2338 H  HB3  . GLU A 1 151 ? -3.86042  -6.99105  7.50276   1.000 33.71575  ? 143 GLU A HB3  1 
ATOM   2339 H  HG2  . GLU A 1 151 ? -3.22551  -6.67807  5.28778   1.000 37.45566  ? 143 GLU A HG2  1 
ATOM   2340 H  HG3  . GLU A 1 151 ? -4.46338  -7.54887  4.80324   1.000 37.45566  ? 143 GLU A HG3  1 
ATOM   2341 N  N    . TYR A 1 152 ? -1.09627  -8.12436  7.48871   1.000 28.87263  ? 144 TYR A N    1 
ATOM   2342 C  CA   . TYR A 1 152 ? 0.29365   -7.78983  7.19580   1.000 23.00440  ? 144 TYR A CA   1 
ATOM   2343 C  C    . TYR A 1 152 ? 1.16438   -8.02268  8.42429   1.000 24.88387  ? 144 TYR A C    1 
ATOM   2344 O  O    . TYR A 1 152 ? 0.67319   -8.27130  9.52709   1.000 26.71597  ? 144 TYR A O    1 
ATOM   2345 C  CB   . TYR A 1 152 ? 0.43498   -6.35034  6.69851   1.000 16.76407  ? 144 TYR A CB   1 
ATOM   2346 C  CG   . TYR A 1 152 ? -0.39810  -5.34455  7.44665   1.000 16.75855  ? 144 TYR A CG   1 
ATOM   2347 C  CD1  . TYR A 1 152 ? -0.01840  -4.90881  8.70626   1.000 17.54661  ? 144 TYR A CD1  1 
ATOM   2348 C  CD2  . TYR A 1 152 ? -1.55937  -4.81587  6.88538   1.000 23.67859  ? 144 TYR A CD2  1 
ATOM   2349 C  CE1  . TYR A 1 152 ? -0.76701  -3.96740  9.39127   1.000 20.06131  ? 144 TYR A CE1  1 
ATOM   2350 C  CE2  . TYR A 1 152 ? -2.32539  -3.87913  7.56697   1.000 21.34504  ? 144 TYR A CE2  1 
ATOM   2351 C  CZ   . TYR A 1 152 ? -1.91966  -3.46505  8.82038   1.000 17.70779  ? 144 TYR A CZ   1 
ATOM   2352 O  OH   . TYR A 1 152 ? -2.66349  -2.55770  9.52175   1.000 21.07105  ? 144 TYR A OH   1 
ATOM   2353 H  H    . TYR A 1 152 ? -1.33017  -7.98148  8.30387   1.000 34.62397  ? 144 TYR A H    1 
ATOM   2354 H  HA   . TYR A 1 152 ? 0.60445   -8.39169  6.50149   1.000 27.58209  ? 144 TYR A HA   1 
ATOM   2355 H  HB2  . TYR A 1 152 ? 1.36352   -6.08358  6.78537   1.000 20.09370  ? 144 TYR A HB2  1 
ATOM   2356 H  HB3  . TYR A 1 152 ? 0.16621   -6.31783  5.76705   1.000 20.09370  ? 144 TYR A HB3  1 
ATOM   2357 H  HD1  . TYR A 1 152 ? 0.75138   -5.25431  9.09737   1.000 21.03274  ? 144 TYR A HD1  1 
ATOM   2358 H  HD2  . TYR A 1 152 ? -1.82595  -5.09541  6.03940   1.000 28.39112  ? 144 TYR A HD2  1 
ATOM   2359 H  HE1  . TYR A 1 152 ? -0.49527  -3.67487  10.23120  1.000 24.05038  ? 144 TYR A HE1  1 
ATOM   2360 H  HE2  . TYR A 1 152 ? -3.10050  -3.53562  7.18475   1.000 25.59086  ? 144 TYR A HE2  1 
ATOM   2361 H  HH   . TYR A 1 152 ? -3.27583  -2.95106  9.94116   1.000 25.26207  ? 144 TYR A HH   1 
ATOM   2362 N  N    . GLY A 1 153 ? 2.47236   -8.00786  8.20151   1.000 22.61554  ? 145 GLY A N    1 
ATOM   2363 C  CA   . GLY A 1 153 ? 3.46345   -8.32776  9.21776   1.000 24.23009  ? 145 GLY A CA   1 
ATOM   2364 C  C    . GLY A 1 153 ? 4.02175   -7.09268  9.89634   1.000 15.23048  ? 145 GLY A C    1 
ATOM   2365 O  O    . GLY A 1 153 ? 3.30201   -6.12621  10.15759  1.000 13.10841  ? 145 GLY A O    1 
ATOM   2366 H  H    . GLY A 1 153 ? 2.82150   -7.80811  7.44138   1.000 27.11546  ? 145 GLY A H    1 
ATOM   2367 H  HA2  . GLY A 1 153 ? 3.05717   -8.89034  9.89551   1.000 29.05292  ? 145 GLY A HA2  1 
ATOM   2368 H  HA3  . GLY A 1 153 ? 4.19913   -8.80878  8.80751   1.000 29.05292  ? 145 GLY A HA3  1 
ATOM   2369 N  N    . PHE A 1 154 ? 5.31758   -7.14215  10.21470  1.000 15.16977  ? 146 PHE A N    1 
ATOM   2370 C  CA   . PHE A 1 154 ? 5.96653   -6.10266  11.01770  1.000 12.98860  ? 146 PHE A CA   1 
ATOM   2371 C  C    . PHE A 1 154 ? 5.21941   -5.89018  12.33335  1.000 19.19448  ? 146 PHE A C    1 
ATOM   2372 O  O    . PHE A 1 154 ? 5.01455   -4.76563  12.78572  1.000 21.93695  ? 146 PHE A O    1 
ATOM   2373 C  CB   . PHE A 1 154 ? 6.07991   -4.79736  10.22448  1.000 22.35098  ? 146 PHE A CB   1 
ATOM   2374 C  CG   . PHE A 1 154 ? 6.94913   -3.74644  10.88273  1.000 16.07707  ? 146 PHE A CG   1 
ATOM   2375 C  CD1  . PHE A 1 154 ? 8.16272   -4.07423  11.45464  1.000 15.66339  ? 146 PHE A CD1  1 
ATOM   2376 C  CD2  . PHE A 1 154 ? 6.53775   -2.43957  10.93093  1.000 17.17826  ? 146 PHE A CD2  1 
ATOM   2377 C  CE1  . PHE A 1 154 ? 8.95298   -3.12289  12.07477  1.000 17.73422  ? 146 PHE A CE1  1 
ATOM   2378 C  CE2  . PHE A 1 154 ? 7.32779   -1.46091  11.53644  1.000 23.71294  ? 146 PHE A CE2  1 
ATOM   2379 C  CZ   . PHE A 1 154 ? 8.54643   -1.81096  12.10989  1.000 22.34262  ? 146 PHE A CZ   1 
ATOM   2380 H  H    . PHE A 1 154 ? 5.84828   -7.77489  9.97472   1.000 18.18054  ? 146 PHE A H    1 
ATOM   2381 H  HA   . PHE A 1 154 ? 6.86544   -6.39233  11.23893  1.000 15.56313  ? 146 PHE A HA   1 
ATOM   2382 H  HB2  . PHE A 1 154 ? 6.46326   -4.99445  9.35552   1.000 26.79799  ? 146 PHE A HB2  1 
ATOM   2383 H  HB3  . PHE A 1 154 ? 5.19237   -4.42079  10.11786  1.000 26.79799  ? 146 PHE A HB3  1 
ATOM   2384 H  HD1  . PHE A 1 154 ? 8.45596   -4.95619  11.42211  1.000 18.77288  ? 146 PHE A HD1  1 
ATOM   2385 H  HD2  . PHE A 1 154 ? 5.72103   -2.20175  10.55502  1.000 20.59072  ? 146 PHE A HD2  1 
ATOM   2386 H  HE1  . PHE A 1 154 ? 9.75860   -3.37120  12.46747  1.000 21.25788  ? 146 PHE A HE1  1 
ATOM   2387 H  HE2  . PHE A 1 154 ? 7.04028   -0.57670  11.55657  1.000 28.43234  ? 146 PHE A HE2  1 
ATOM   2388 H  HZ   . PHE A 1 154 ? 9.07973   -1.16407  12.51242  1.000 26.78796  ? 146 PHE A HZ   1 
ATOM   2389 N  N    . GLN A 1 155 ? 4.80723   -6.98861  12.95646  1.000 13.93328  ? 147 GLN A N    1 
ATOM   2390 C  CA   . GLN A 1 155 ? 4.02772   -6.95441  14.18536  1.000 15.90992  ? 147 GLN A CA   1 
ATOM   2391 C  C    . GLN A 1 155 ? 4.94288   -7.11345  15.39437  1.000 16.12721  ? 147 GLN A C    1 
ATOM   2392 O  O    . GLN A 1 155 ? 6.10063   -7.51919  15.27824  1.000 18.99380  ? 147 GLN A O    1 
ATOM   2393 C  CB   . GLN A 1 155 ? 2.98557   -8.08009  14.22823  1.000 16.90955  ? 147 GLN A CB   1 
ATOM   2394 C  CG   . GLN A 1 155 ? 2.00697   -8.12571  13.08486  1.000 22.48249  ? 147 GLN A CG   1 
ATOM   2395 C  CD   . GLN A 1 155 ? 0.95681   -9.18169  13.29345  1.000 22.50681  ? 147 GLN A CD   1 
ATOM   2396 O  OE1  . GLN A 1 155 ? 0.79259   -9.71683  14.39593  1.000 17.56485  ? 147 GLN A OE1  1 
ATOM   2397 N  NE2  . GLN A 1 155 ? 0.24369   -9.50194  12.23292  1.000 24.90111  ? 147 GLN A NE2  1 
ATOM   2398 H  H    . GLN A 1 155 ? 4.97110   -7.78604  12.67923  1.000 16.69674  ? 147 GLN A H    1 
ATOM   2399 H  HA   . GLN A 1 155 ? 3.56785   -6.10092  14.21688  1.000 19.06871  ? 147 GLN A HA   1 
ATOM   2400 H  HB2  . GLN A 1 155 ? 3.45681   -8.92790  14.23457  1.000 20.26827  ? 147 GLN A HB2  1 
ATOM   2401 H  HB3  . GLN A 1 155 ? 2.46828   -7.98195  15.04290  1.000 20.26827  ? 147 GLN A HB3  1 
ATOM   2402 H  HG2  . GLN A 1 155 ? 1.56356   -7.26637  13.00850  1.000 26.95580  ? 147 GLN A HG2  1 
ATOM   2403 H  HG3  . GLN A 1 155 ? 2.48282   -8.32759  12.26407  1.000 26.95580  ? 147 GLN A HG3  1 
ATOM   2404 H  HE21 . GLN A 1 155 ? 0.39332   -9.11297  11.48065  1.000 29.85814  ? 147 GLN A HE21 1 
ATOM   2405 H  HE22 . GLN A 1 155 ? -0.37143  -10.09996 12.29294  1.000 29.85814  ? 147 GLN A HE22 1 
ATOM   2406 N  N    . PHE A 1 156 ? 4.37439   -6.88420  16.57736  1.000 20.85452  ? 148 PHE A N    1 
ATOM   2407 C  CA   . PHE A 1 156 ? 5.06768   -7.09944  17.84821  1.000 16.91342  ? 148 PHE A CA   1 
ATOM   2408 C  C    . PHE A 1 156 ? 4.09722   -7.82963  18.77135  1.000 23.14047  ? 148 PHE A C    1 
ATOM   2409 O  O    . PHE A 1 156 ? 3.15184   -7.22615  19.29602  1.000 16.45676  ? 148 PHE A O    1 
ATOM   2410 C  CB   . PHE A 1 156 ? 5.54175   -5.77588  18.42213  1.000 16.42202  ? 148 PHE A CB   1 
ATOM   2411 C  CG   . PHE A 1 156 ? 6.59698   -5.11476  17.58456  1.000 17.51366  ? 148 PHE A CG   1 
ATOM   2412 C  CD1  . PHE A 1 156 ? 6.24886   -4.40097  16.44368  1.000 19.59906  ? 148 PHE A CD1  1 
ATOM   2413 C  CD2  . PHE A 1 156 ? 7.93116   -5.23023  17.90828  1.000 17.44774  ? 148 PHE A CD2  1 
ATOM   2414 C  CE1  . PHE A 1 156 ? 7.20613   -3.78509  15.66081  1.000 22.86674  ? 148 PHE A CE1  1 
ATOM   2415 C  CE2  . PHE A 1 156 ? 8.89311   -4.62928  17.11420  1.000 23.02872  ? 148 PHE A CE2  1 
ATOM   2416 C  CZ   . PHE A 1 156 ? 8.53161   -3.89863  16.00158  1.000 19.24438  ? 148 PHE A CZ   1 
ATOM   2417 H  H    . PHE A 1 156 ? 3.56939   -6.59702  16.67278  1.000 25.00224  ? 148 PHE A H    1 
ATOM   2418 H  HA   . PHE A 1 156 ? 5.84354   -7.66885  17.72686  1.000 20.27292  ? 148 PHE A HA   1 
ATOM   2419 H  HB2  . PHE A 1 156 ? 4.78600   -5.17086  18.48289  1.000 19.68323  ? 148 PHE A HB2  1 
ATOM   2420 H  HB3  . PHE A 1 156 ? 5.91422   -5.93110  19.30422  1.000 19.68323  ? 148 PHE A HB3  1 
ATOM   2421 H  HD1  . PHE A 1 156 ? 5.35300   -4.33669  16.20241  1.000 23.49568  ? 148 PHE A HD1  1 
ATOM   2422 H  HD2  . PHE A 1 156 ? 8.18605   -5.71262  18.66143  1.000 20.91410  ? 148 PHE A HD2  1 
ATOM   2423 H  HE1  . PHE A 1 156 ? 6.95509   -3.29782  14.90951  1.000 27.41690  ? 148 PHE A HE1  1 
ATOM   2424 H  HE2  . PHE A 1 156 ? 9.79244   -4.71923  17.33332  1.000 27.61128  ? 148 PHE A HE2  1 
ATOM   2425 H  HZ   . PHE A 1 156 ? 9.18350   -3.48413  15.48375  1.000 23.07006  ? 148 PHE A HZ   1 
ATOM   2426 N  N    . SER A 1 157 ? 4.32583   -9.13972  18.94341  1.000 18.05865  ? 149 SER A N    1 
ATOM   2427 C  CA   . SER A 1 157 ? 3.34302   -10.03967 19.53817  1.000 17.36886  ? 149 SER A CA   1 
ATOM   2428 C  C    . SER A 1 157 ? 3.32653   -9.99926  21.06005  1.000 18.81357  ? 149 SER A C    1 
ATOM   2429 O  O    . SER A 1 157 ? 2.41184   -10.56724 21.66506  1.000 15.86464  ? 149 SER A O    1 
ATOM   2430 C  CB   . SER A 1 157 ? 3.60485   -11.47377 19.06992  1.000 19.63949  ? 149 SER A CB   1 
ATOM   2431 O  OG   . SER A 1 157 ? 4.89182   -11.89793 19.50398  1.000 18.62030  ? 149 SER A OG   1 
ATOM   2432 H  H    . SER A 1 157 ? 5.05669   -9.53308  18.71819  1.000 21.64719  ? 149 SER A H    1 
ATOM   2433 H  HA   . SER A 1 157 ? 2.46149   -9.77429  19.23260  1.000 20.81944  ? 149 SER A HA   1 
ATOM   2434 H  HB2  . SER A 1 157 ? 2.93100   -12.06095 19.44681  1.000 23.54420  ? 149 SER A HB2  1 
ATOM   2435 H  HB3  . SER A 1 157 ? 3.56801   -11.50527 18.10113  1.000 23.54420  ? 149 SER A HB3  1 
ATOM   2436 H  HG   . SER A 1 157 ? 5.48700   -11.43614 19.13235  1.000 22.32117  ? 149 SER A HG   1 
ATOM   2437 N  N    . GLU A 1 158 ? 4.29062   -9.33886  21.69205  1.000 15.43406  ? 150 GLU A N    1 
ATOM   2438 C  CA   . GLU A 1 158 ? 4.30095   -9.19460  23.13892  1.000 14.35234  ? 150 GLU A CA   1 
ATOM   2439 C  C    . GLU A 1 158 ? 5.28260   -8.09494  23.49353  1.000 18.96491  ? 150 GLU A C    1 
ATOM   2440 O  O    . GLU A 1 158 ? 6.18534   -7.78737  22.70565  1.000 17.03011  ? 150 GLU A O    1 
ATOM   2441 C  CB   . GLU A 1 158 ? 4.66918   -10.51372 23.84561  1.000 17.82990  ? 150 GLU A CB   1 
ATOM   2442 C  CG   . GLU A 1 158 ? 5.98517   -11.13637 23.44142  1.000 22.12741  ? 150 GLU A CG   1 
ATOM   2443 C  CD   . GLU A 1 158 ? 6.34792   -12.34190 24.31824  1.000 38.57825  ? 150 GLU A CD   1 
ATOM   2444 O  OE1  . GLU A 1 158 ? 6.06750   -12.31393 25.53763  1.000 26.03629  ? 150 GLU A OE1  1 
ATOM   2445 O  OE2  . GLU A 1 158 ? 6.92136   -13.31964 23.79255  1.000 38.87304  ? 150 GLU A OE2  1 
ATOM   2446 H  H    . GLU A 1 158 ? 4.95611   -8.96202  21.29870  1.000 18.49769  ? 150 GLU A H    1 
ATOM   2447 H  HA   . GLU A 1 158 ? 3.41894   -8.93328  23.44661  1.000 17.19961  ? 150 GLU A HA   1 
ATOM   2448 H  HB2  . GLU A 1 158 ? 4.71332   -10.34438 24.79969  1.000 21.37269  ? 150 GLU A HB2  1 
ATOM   2449 H  HB3  . GLU A 1 158 ? 3.97443   -11.16347 23.65577  1.000 21.37269  ? 150 GLU A HB3  1 
ATOM   2450 H  HG2  . GLU A 1 158 ? 5.92540   -11.43837 22.52157  1.000 26.52971  ? 150 GLU A HG2  1 
ATOM   2451 H  HG3  . GLU A 1 158 ? 6.69013   -10.47582 23.52859  1.000 26.52971  ? 150 GLU A HG3  1 
ATOM   2452 N  N    . PRO A 1 159 ? 5.12510   -7.47136  24.65754  1.000 15.90479  ? 151 PRO A N    1 
ATOM   2453 C  CA   . PRO A 1 159 ? 5.99739   -6.32668  24.98815  1.000 16.91015  ? 151 PRO A CA   1 
ATOM   2454 C  C    . PRO A 1 159 ? 7.47921   -6.63201  24.85197  1.000 17.65752  ? 151 PRO A C    1 
ATOM   2455 O  O    . PRO A 1 159 ? 8.24965   -5.77059  24.40928  1.000 17.14389  ? 151 PRO A O    1 
ATOM   2456 C  CB   . PRO A 1 159 ? 5.61568   -5.99334  26.43935  1.000 18.21854  ? 151 PRO A CB   1 
ATOM   2457 C  CG   . PRO A 1 159 ? 4.19600   -6.50812  26.58820  1.000 17.35085  ? 151 PRO A CG   1 
ATOM   2458 C  CD   . PRO A 1 159 ? 4.12859   -7.75519  25.70679  1.000 17.21411  ? 151 PRO A CD   1 
ATOM   2459 H  HA   . PRO A 1 159 ? 5.77001   -5.57499  24.41881  1.000 20.26899  ? 151 PRO A HA   1 
ATOM   2460 H  HB2  . PRO A 1 159 ? 6.21645   -6.44482  27.05265  1.000 21.83906  ? 151 PRO A HB2  1 
ATOM   2461 H  HB3  . PRO A 1 159 ? 5.65567   -5.03461  26.58123  1.000 21.83906  ? 151 PRO A HB3  1 
ATOM   2462 H  HG2  . PRO A 1 159 ? 4.02113   -6.73027  27.51609  1.000 20.79784  ? 151 PRO A HG2  1 
ATOM   2463 H  HG3  . PRO A 1 159 ? 3.56731   -5.83496  26.28406  1.000 20.79784  ? 151 PRO A HG3  1 
ATOM   2464 H  HD2  . PRO A 1 159 ? 4.37089   -8.54856  26.20952  1.000 20.63375  ? 151 PRO A HD2  1 
ATOM   2465 H  HD3  . PRO A 1 159 ? 3.24353   -7.86211  25.32452  1.000 20.63375  ? 151 PRO A HD3  1 
ATOM   2466 N  N    . LYS A 1 160 ? 7.89628   -7.84790  25.20094  1.000 16.23495  ? 152 LYS A N    1 
ATOM   2467 C  CA   . LYS A 1 160 ? 9.30530   -8.21885  25.08947  1.000 20.77720  ? 152 LYS A CA   1 
ATOM   2468 C  C    . LYS A 1 160 ? 9.85269   -7.97209  23.68124  1.000 19.40611  ? 152 LYS A C    1 
ATOM   2469 O  O    . LYS A 1 160 ? 11.00656  -7.55157  23.50461  1.000 16.32156  ? 152 LYS A O    1 
ATOM   2470 C  CB   . LYS A 1 160 ? 9.44281   -9.68783  25.47579  1.000 20.43728  ? 152 LYS A CB   1 
ATOM   2471 C  CG   . LYS A 1 160 ? 10.84464  -10.23281 25.57171  1.000 33.16142  ? 152 LYS A CG   1 
ATOM   2472 C  CD   . LYS A 1 160 ? 10.77407  -11.72153 25.96074  1.000 29.77937  ? 152 LYS A CD   1 
ATOM   2473 C  CE   . LYS A 1 160 ? 12.15706  -12.31605 26.18629  1.000 42.27776  ? 152 LYS A CE   1 
ATOM   2474 N  NZ   . LYS A 1 160 ? 12.03783  -13.71189 26.72112  1.000 40.60063  ? 152 LYS A NZ   1 
ATOM   2475 H  H    . LYS A 1 160 ? 7.38814   -8.47250  25.50304  1.000 19.45875  ? 152 LYS A H    1 
ATOM   2476 H  HA   . LYS A 1 160 ? 9.83580   -7.67675  25.69411  1.000 24.90945  ? 152 LYS A HA   1 
ATOM   2477 H  HB2  . LYS A 1 160 ? 9.03083   -9.80975  26.34545  1.000 24.50155  ? 152 LYS A HB2  1 
ATOM   2478 H  HB3  . LYS A 1 160 ? 8.97697   -10.21842 24.81068  1.000 24.50155  ? 152 LYS A HB3  1 
ATOM   2479 H  HG2  . LYS A 1 160 ? 11.29132  -10.15106 24.71457  1.000 39.77051  ? 152 LYS A HG2  1 
ATOM   2480 H  HG3  . LYS A 1 160 ? 11.34139  -9.75170  26.25191  1.000 39.77051  ? 152 LYS A HG3  1 
ATOM   2481 H  HD2  . LYS A 1 160 ? 10.26692  -11.81355 26.78247  1.000 35.71206  ? 152 LYS A HD2  1 
ATOM   2482 H  HD3  . LYS A 1 160 ? 10.34326  -12.21826 25.24761  1.000 35.71206  ? 152 LYS A HD3  1 
ATOM   2483 H  HE2  . LYS A 1 160 ? 12.64063  -12.34548 25.34594  1.000 50.71013  ? 152 LYS A HE2  1 
ATOM   2484 H  HE3  . LYS A 1 160 ? 12.64295  -11.77706 26.82995  1.000 50.71013  ? 152 LYS A HE3  1 
ATOM   2485 H  HZ1  . LYS A 1 160 ? 12.67302  -13.86125 27.32637  1.000 48.69757  ? 152 LYS A HZ1  1 
ATOM   2486 H  HZ2  . LYS A 1 160 ? 11.24215  -13.82435 27.10369  1.000 48.69757  ? 152 LYS A HZ2  1 
ATOM   2487 H  HZ3  . LYS A 1 160 ? 12.12570  -14.30010 26.05902  1.000 48.69757  ? 152 LYS A HZ3  1 
ATOM   2488 N  N    . GLU A 1 161 ? 9.03548   -8.21808  22.66148  1.000 23.26541  ? 153 GLU A N    1 
ATOM   2489 C  CA   . GLU A 1 161 ? 9.49832   -7.99466  21.29565  1.000 23.69098  ? 153 GLU A CA   1 
ATOM   2490 C  C    . GLU A 1 161 ? 9.85018   -6.52817  21.04517  1.000 16.71228  ? 153 GLU A C    1 
ATOM   2491 O  O    . GLU A 1 161 ? 10.74862  -6.23726  20.23814  1.000 13.12897  ? 153 GLU A O    1 
ATOM   2492 C  CB   . GLU A 1 161 ? 8.43371   -8.46775  20.30359  1.000 20.27226  ? 153 GLU A CB   1 
ATOM   2493 C  CG   . GLU A 1 161 ? 8.15915   -9.95376  20.36714  1.000 19.84005  ? 153 GLU A CG   1 
ATOM   2494 C  CD   . GLU A 1 161 ? 9.39395   -10.77226 20.03344  1.000 27.49306  ? 153 GLU A CD   1 
ATOM   2495 O  OE1  . GLU A 1 161 ? 10.32835  -10.20683 19.41295  1.000 26.09620  ? 153 GLU A OE1  1 
ATOM   2496 O  OE2  . GLU A 1 161 ? 9.43203   -11.96808 20.40309  1.000 25.93374  ? 153 GLU A OE2  1 
ATOM   2497 H  H    . GLU A 1 161 ? 8.22859   -8.50751  22.73045  1.000 27.89530  ? 153 GLU A H    1 
ATOM   2498 H  HA   . GLU A 1 161 ? 10.30230  -8.51719  21.14912  1.000 28.40599  ? 153 GLU A HA   1 
ATOM   2499 H  HB2  . GLU A 1 161 ? 7.60281   -8.00468  20.49350  1.000 24.30353  ? 153 GLU A HB2  1 
ATOM   2500 H  HB3  . GLU A 1 161 ? 8.73132   -8.25977  19.40410  1.000 24.30353  ? 153 GLU A HB3  1 
ATOM   2501 H  HG2  . GLU A 1 161 ? 7.87305   -10.18769 21.26398  1.000 23.78487  ? 153 GLU A HG2  1 
ATOM   2502 H  HG3  . GLU A 1 161 ? 7.46453   -10.17789 19.72827  1.000 23.78487  ? 153 GLU A HG3  1 
ATOM   2503 N  N    . ILE A 1 162 ? 9.14445   -5.59407  21.69793  1.000 15.06180  ? 154 ILE A N    1 
ATOM   2504 C  CA   . ILE A 1 162 ? 9.46323   -4.17856  21.51937  1.000 15.52386  ? 154 ILE A CA   1 
ATOM   2505 C  C    . ILE A 1 162 ? 10.81221  -3.86960  22.14337  1.000 16.13918  ? 154 ILE A C    1 
ATOM   2506 O  O    . ILE A 1 162 ? 11.61999  -3.12519  21.57517  1.000 19.34692  ? 154 ILE A O    1 
ATOM   2507 C  CB   . ILE A 1 162 ? 8.36137   -3.27684  22.10590  1.000 13.21507  ? 154 ILE A CB   1 
ATOM   2508 C  CG1  . ILE A 1 162 ? 7.00790   -3.62311  21.48238  1.000 17.52152  ? 154 ILE A CG1  1 
ATOM   2509 C  CG2  . ILE A 1 162 ? 8.69990   -1.82275  21.86233  1.000 13.16985  ? 154 ILE A CG2  1 
ATOM   2510 C  CD1  . ILE A 1 162 ? 5.81683   -2.85913  22.07929  1.000 15.68734  ? 154 ILE A CD1  1 
ATOM   2511 H  H    . ILE A 1 162 ? 8.49273   -5.75302  22.23608  1.000 18.05097  ? 154 ILE A H    1 
ATOM   2512 H  HA   . ILE A 1 162 ? 9.50682   -4.00011  20.56692  1.000 18.60544  ? 154 ILE A HA   1 
ATOM   2513 H  HB   . ILE A 1 162 ? 8.30776   -3.42997  23.06224  1.000 15.83489  ? 154 ILE A HB   1 
ATOM   2514 H  HG12 . ILE A 1 162 ? 7.04255   -3.41745  20.53506  1.000 21.00264  ? 154 ILE A HG12 1 
ATOM   2515 H  HG13 . ILE A 1 162 ? 6.84207   -4.57021  21.61041  1.000 21.00264  ? 154 ILE A HG13 1 
ATOM   2516 H  HG21 . ILE A 1 162 ? 8.00022   -1.26788  22.24111  1.000 15.78063  ? 154 ILE A HG21 1 
ATOM   2517 H  HG22 . ILE A 1 162 ? 9.54843   -1.62069  22.28666  1.000 15.78063  ? 154 ILE A HG22 1 
ATOM   2518 H  HG23 . ILE A 1 162 ? 8.76305   -1.66900  20.90668  1.000 15.78063  ? 154 ILE A HG23 1 
ATOM   2519 H  HD11 . ILE A 1 162 ? 4.99728   -3.18921  21.67892  1.000 18.80162  ? 154 ILE A HD11 1 
ATOM   2520 H  HD12 . ILE A 1 162 ? 5.79784   -3.00322  23.03834  1.000 18.80162  ? 154 ILE A HD12 1 
ATOM   2521 H  HD13 . ILE A 1 162 ? 5.92060   -1.91369  21.88882  1.000 18.80162  ? 154 ILE A HD13 1 
ATOM   2522 N  N    . ALA A 1 163 ? 11.07770  -4.43686  23.32280  1.000 18.93853  ? 155 ALA A N    1 
ATOM   2523 C  CA   . ALA A 1 163 ? 12.38486  -4.28226  23.94797  1.000 17.42087  ? 155 ALA A CA   1 
ATOM   2524 C  C    . ALA A 1 163 ? 13.47913  -4.89103  23.08485  1.000 13.29312  ? 155 ALA A C    1 
ATOM   2525 O  O    . ALA A 1 163 ? 14.55926  -4.31237  22.94218  1.000 17.27369  ? 155 ALA A O    1 
ATOM   2526 C  CB   . ALA A 1 163 ? 12.38800  -4.92993  25.33071  1.000 15.83957  ? 155 ALA A CB   1 
ATOM   2527 H  H    . ALA A 1 163 ? 10.52144  -4.91148  23.77547  1.000 22.70305  ? 155 ALA A H    1 
ATOM   2528 H  HA   . ALA A 1 163 ? 12.56697  -3.33557  24.05525  1.000 20.88186  ? 155 ALA A HA   1 
ATOM   2529 H  HB1  . ALA A 1 163 ? 13.26071  -4.80590  25.73555  1.000 18.98429  ? 155 ALA A HB1  1 
ATOM   2530 H  HB2  . ALA A 1 163 ? 11.70664  -4.50916  25.87807  1.000 18.98429  ? 155 ALA A HB2  1 
ATOM   2531 H  HB3  . ALA A 1 163 ? 12.19860  -5.87658  25.23647  1.000 18.98429  ? 155 ALA A HB3  1 
ATOM   2532 N  N    . ARG A 1 164 ? 13.21653  -6.05598  22.49527  1.000 16.75561  ? 156 ARG A N    1 
ATOM   2533 C  CA   . ARG A 1 164 ? 14.20825  -6.69099  21.63068  1.000 19.67136  ? 156 ARG A CA   1 
ATOM   2534 C  C    . ARG A 1 164 ? 14.50084  -5.82533  20.41011  1.000 18.38563  ? 156 ARG A C    1 
ATOM   2535 O  O    . ARG A 1 164 ? 15.66188  -5.60751  20.04107  1.000 18.52697  ? 156 ARG A O    1 
ATOM   2536 C  CB   . ARG A 1 164 ? 13.70959  -8.07303  21.20280  1.000 24.97739  ? 156 ARG A CB   1 
ATOM   2537 C  CG   . ARG A 1 164 ? 14.71021  -8.86639  20.33355  1.000 17.43568  ? 156 ARG A CG   1 
ATOM   2538 C  CD   . ARG A 1 164 ? 14.45109  -10.34660 20.41239  1.000 32.81747  ? 156 ARG A CD   1 
ATOM   2539 N  NE   . ARG A 1 164 ? 13.25666  -10.76847 19.69398  1.000 21.56239  ? 156 ARG A NE   1 
ATOM   2540 C  CZ   . ARG A 1 164 ? 13.17667  -11.89492 18.98675  1.000 41.29697  ? 156 ARG A CZ   1 
ATOM   2541 N  NH1  . ARG A 1 164 ? 14.22557  -12.71695 18.88962  1.000 35.02515  ? 156 ARG A NH1  1 
ATOM   2542 N  NH2  . ARG A 1 164 ? 12.04254  -12.21156 18.37012  1.000 33.06189  ? 156 ARG A NH2  1 
ATOM   2543 H  H    . ARG A 1 164 ? 12.48132  -6.49441  22.57799  1.000 20.08354  ? 156 ARG A H    1 
ATOM   2544 H  HA   . ARG A 1 164 ? 15.03469  -6.80439  22.12569  1.000 23.58244  ? 156 ARG A HA   1 
ATOM   2545 H  HB2  . ARG A 1 164 ? 13.53040  -8.59802  21.99853  1.000 29.94968  ? 156 ARG A HB2  1 
ATOM   2546 H  HB3  . ARG A 1 164 ? 12.89512  -7.96295  20.68761  1.000 29.94968  ? 156 ARG A HB3  1 
ATOM   2547 H  HG2  . ARG A 1 164 ? 14.62235  -8.58978  19.40799  1.000 20.89962  ? 156 ARG A HG2  1 
ATOM   2548 H  HG3  . ARG A 1 164 ? 15.61275  -8.69721  20.64612  1.000 20.89962  ? 156 ARG A HG3  1 
ATOM   2549 H  HD2  . ARG A 1 164 ? 15.20820  -10.81771 20.03061  1.000 39.35778  ? 156 ARG A HD2  1 
ATOM   2550 H  HD3  . ARG A 1 164 ? 14.34034  -10.59587 21.34325  1.000 39.35778  ? 156 ARG A HD3  1 
ATOM   2551 H  HE   . ARG A 1 164 ? 12.56294  -10.26134 19.72815  1.000 25.85168  ? 156 ARG A HE   1 
ATOM   2552 H  HH11 . ARG A 1 164 ? 14.96323  -12.52151 19.28618  1.000 42.00699  ? 156 ARG A HH11 1 
ATOM   2553 H  HH12 . ARG A 1 164 ? 14.16302  -13.44147 18.43053  1.000 42.00699  ? 156 ARG A HH12 1 
ATOM   2554 H  HH21 . ARG A 1 164 ? 11.36147  -11.68964 18.42787  1.000 39.65108  ? 156 ARG A HH21 1 
ATOM   2555 H  HH22 . ARG A 1 164 ? 11.98982  -12.93835 17.91340  1.000 39.65108  ? 156 ARG A HH22 1 
ATOM   2556 N  N    . PHE A 1 165 ? 13.44691  -5.30824  19.78052  1.000 19.38116  ? 157 PHE A N    1 
ATOM   2557 C  CA   . PHE A 1 165 ? 13.61507  -4.40997  18.64187  1.000 16.75461  ? 157 PHE A CA   1 
ATOM   2558 C  C    . PHE A 1 165 ? 14.47979  -3.20720  19.01513  1.000 17.65017  ? 157 PHE A C    1 
ATOM   2559 O  O    . PHE A 1 165 ? 15.39921  -2.83574  18.27232  1.000 20.13100  ? 157 PHE A O    1 
ATOM   2560 C  CB   . PHE A 1 165 ? 12.22827  -3.98667  18.13812  1.000 10.53259  ? 157 PHE A CB   1 
ATOM   2561 C  CG   . PHE A 1 165 ? 12.24748  -2.88987  17.10406  1.000 15.63819  ? 157 PHE A CG   1 
ATOM   2562 C  CD1  . PHE A 1 165 ? 12.66079  -3.14914  15.81119  1.000 17.74847  ? 157 PHE A CD1  1 
ATOM   2563 C  CD2  . PHE A 1 165 ? 11.84214  -1.60104  17.42295  1.000 23.21552  ? 157 PHE A CD2  1 
ATOM   2564 C  CE1  . PHE A 1 165 ? 12.67029  -2.14221  14.85662  1.000 22.22287  ? 157 PHE A CE1  1 
ATOM   2565 C  CE2  . PHE A 1 165 ? 11.85501  -0.59493  16.47104  1.000 17.83954  ? 157 PHE A CE2  1 
ATOM   2566 C  CZ   . PHE A 1 165 ? 12.27005  -0.86139  15.19792  1.000 15.04438  ? 157 PHE A CZ   1 
ATOM   2567 H  H    . PHE A 1 165 ? 12.62729  -5.46074  19.99163  1.000 23.23420  ? 157 PHE A H    1 
ATOM   2568 H  HA   . PHE A 1 165 ? 14.06943  -4.86650  17.91658  1.000 20.08234  ? 157 PHE A HA   1 
ATOM   2569 H  HB2  . PHE A 1 165 ? 11.79562  -4.75781  17.73930  1.000 12.61592  ? 157 PHE A HB2  1 
ATOM   2570 H  HB3  . PHE A 1 165 ? 11.70900  -3.66849  18.89311  1.000 12.61592  ? 157 PHE A HB3  1 
ATOM   2571 H  HD1  . PHE A 1 165 ? 12.93521  -4.00677  15.57867  1.000 21.27497  ? 157 PHE A HD1  1 
ATOM   2572 H  HD2  . PHE A 1 165 ? 11.55801  -1.41048  18.28774  1.000 27.83543  ? 157 PHE A HD2  1 
ATOM   2573 H  HE1  . PHE A 1 165 ? 12.94542  -2.32754  13.98779  1.000 26.64425  ? 157 PHE A HE1  1 
ATOM   2574 H  HE2  . PHE A 1 165 ? 11.58042  0.26372   16.69953  1.000 21.38426  ? 157 PHE A HE2  1 
ATOM   2575 H  HZ   . PHE A 1 165 ? 12.28391  -0.18379  14.56107  1.000 18.03006  ? 157 PHE A HZ   1 
ATOM   2576 N  N    . ILE A 1 166 ? 14.22683  -2.60371  20.17425  1.000 15.56361  ? 158 ILE A N    1 
ATOM   2577 C  CA   . ILE A 1 166 ? 14.94626  -1.39061  20.54844  1.000 15.26655  ? 158 ILE A CA   1 
ATOM   2578 C  C    . ILE A 1 166 ? 16.39789  -1.71153  20.88743  1.000 18.93062  ? 158 ILE A C    1 
ATOM   2579 O  O    . ILE A 1 166 ? 17.33309  -1.11198  20.33964  1.000 16.01112  ? 158 ILE A O    1 
ATOM   2580 C  CB   . ILE A 1 166 ? 14.23018  -0.69612  21.71905  1.000 17.74473  ? 158 ILE A CB   1 
ATOM   2581 C  CG1  . ILE A 1 166 ? 12.89055  -0.11505  21.24393  1.000 23.96274  ? 158 ILE A CG1  1 
ATOM   2582 C  CG2  . ILE A 1 166 ? 15.12355  0.40442   22.32054  1.000 21.92284  ? 158 ILE A CG2  1 
ATOM   2583 C  CD1  . ILE A 1 166 ? 11.90719  0.19402   22.38419  1.000 19.05455  ? 158 ILE A CD1  1 
ATOM   2584 H  H    . ILE A 1 166 ? 13.65132  -2.87261  20.75398  1.000 18.65314  ? 158 ILE A H    1 
ATOM   2585 H  HA   . ILE A 1 166 ? 14.94974  -0.78416  19.79140  1.000 18.29667  ? 158 ILE A HA   1 
ATOM   2586 H  HB   . ILE A 1 166 ? 14.05366  -1.35295  22.41066  1.000 21.27049  ? 158 ILE A HB   1 
ATOM   2587 H  HG12 . ILE A 1 166 ? 13.06137  0.71295   20.76838  1.000 28.73210  ? 158 ILE A HG12 1 
ATOM   2588 H  HG13 . ILE A 1 166 ? 12.46544  -0.75567  20.65251  1.000 28.73210  ? 158 ILE A HG13 1 
ATOM   2589 H  HG21 . ILE A 1 166 ? 14.61169  0.90345   22.97618  1.000 26.28422  ? 158 ILE A HG21 1 
ATOM   2590 H  HG22 . ILE A 1 166 ? 15.89132  -0.00911  22.74531  1.000 26.28422  ? 158 ILE A HG22 1 
ATOM   2591 H  HG23 . ILE A 1 166 ? 15.41731  0.99605   21.61019  1.000 26.28422  ? 158 ILE A HG23 1 
ATOM   2592 H  HD11 . ILE A 1 166 ? 11.08063  0.53205   22.00546  1.000 22.84227  ? 158 ILE A HD11 1 
ATOM   2593 H  HD12 . ILE A 1 166 ? 11.73431  -0.62059  22.88160  1.000 22.84227  ? 158 ILE A HD12 1 
ATOM   2594 H  HD13 . ILE A 1 166 ? 12.30053  0.86109   22.96831  1.000 22.84227  ? 158 ILE A HD13 1 
ATOM   2595 N  N    . ASP A 1 167 ? 16.60505  -2.65541  21.80784  1.000 20.33524  ? 159 ASP A N    1 
ATOM   2596 C  CA   . ASP A 1 167 ? 17.95708  -2.96914  22.26305  1.000 19.38466  ? 159 ASP A CA   1 
ATOM   2597 C  C    . ASP A 1 167 ? 18.87519  -3.35910  21.10601  1.000 26.56534  ? 159 ASP A C    1 
ATOM   2598 O  O    . ASP A 1 167 ? 20.02546  -2.90330  21.03545  1.000 25.85764  ? 159 ASP A O    1 
ATOM   2599 C  CB   . ASP A 1 167 ? 17.91299  -4.09029  23.29672  1.000 18.94582  ? 159 ASP A CB   1 
ATOM   2600 C  CG   . ASP A 1 167 ? 19.15855  -4.12406  24.15881  1.000 22.65811  ? 159 ASP A CG   1 
ATOM   2601 O  OD1  . ASP A 1 167 ? 19.77585  -3.05221  24.36074  1.000 28.14291  ? 159 ASP A OD1  1 
ATOM   2602 O  OD2  . ASP A 1 167 ? 19.51847  -5.22269  24.62044  1.000 25.66099  ? 159 ASP A OD2  1 
ATOM   2603 H  H    . ASP A 1 167 ? 15.98660  -3.12302  22.17994  1.000 24.37910  ? 159 ASP A H    1 
ATOM   2604 H  HA   . ASP A 1 167 ? 18.32638  -2.17518  22.68035  1.000 23.23840  ? 159 ASP A HA   1 
ATOM   2605 H  HB2  . ASP A 1 167 ? 17.14719  -3.95795  23.87717  1.000 22.71179  ? 159 ASP A HB2  1 
ATOM   2606 H  HB3  . ASP A 1 167 ? 17.83904  -4.94231  22.83901  1.000 22.71179  ? 159 ASP A HB3  1 
ATOM   2607 N  N    . VAL A 1 168 ? 18.37219  -4.15891  20.16413  1.000 21.54546  ? 160 VAL A N    1 
ATOM   2608 C  CA   . VAL A 1 168 ? 19.23453  -4.72289  19.13183  1.000 20.32168  ? 160 VAL A CA   1 
ATOM   2609 C  C    . VAL A 1 168 ? 19.46994  -3.73327  18.00337  1.000 19.43035  ? 160 VAL A C    1 
ATOM   2610 O  O    . VAL A 1 168 ? 20.56974  -3.67264  17.45021  1.000 26.89322  ? 160 VAL A O    1 
ATOM   2611 C  CB   . VAL A 1 168 ? 18.63263  -6.03646  18.60052  1.000 23.81489  ? 160 VAL A CB   1 
ATOM   2612 C  CG1  . VAL A 1 168 ? 19.39518  -6.53790  17.37977  1.000 22.76521  ? 160 VAL A CG1  1 
ATOM   2613 C  CG2  . VAL A 1 168 ? 18.60607  -7.09932  19.69861  1.000 22.91458  ? 160 VAL A CG2  1 
ATOM   2614 H  H    . VAL A 1 168 ? 17.54516  -4.38664  20.10281  1.000 25.83136  ? 160 VAL A H    1 
ATOM   2615 H  HA   . VAL A 1 168 ? 20.09443  -4.91741  19.53633  1.000 24.36282  ? 160 VAL A HA   1 
ATOM   2616 H  HB   . VAL A 1 168 ? 17.71889  -5.86416  18.32429  1.000 28.55467  ? 160 VAL A HB   1 
ATOM   2617 H  HG11 . VAL A 1 168 ? 19.06555  -7.41845  17.14126  1.000 27.29507  ? 160 VAL A HG11 1 
ATOM   2618 H  HG12 . VAL A 1 168 ? 19.25417  -5.92150  16.64419  1.000 27.29507  ? 160 VAL A HG12 1 
ATOM   2619 H  HG13 . VAL A 1 168 ? 20.33979  -6.58544  17.59505  1.000 27.29507  ? 160 VAL A HG13 1 
ATOM   2620 H  HG21 . VAL A 1 168 ? 18.24059  -7.92068  19.33434  1.000 27.47430  ? 160 VAL A HG21 1 
ATOM   2621 H  HG22 . VAL A 1 168 ? 19.51099  -7.25092  20.01333  1.000 27.47430  ? 160 VAL A HG22 1 
ATOM   2622 H  HG23 . VAL A 1 168 ? 18.05018  -6.78517  20.42881  1.000 27.47430  ? 160 VAL A HG23 1 
ATOM   2623 N  N    . PHE A 1 169 ? 18.45355  -2.95886  17.62028  1.000 20.57650  ? 161 PHE A N    1 
ATOM   2624 C  CA   . PHE A 1 169 ? 18.53108  -2.19110  16.38584  1.000 19.73117  ? 161 PHE A CA   1 
ATOM   2625 C  C    . PHE A 1 169 ? 18.53910  -0.68336  16.56360  1.000 26.37276  ? 161 PHE A C    1 
ATOM   2626 O  O    . PHE A 1 169 ? 18.91306  0.01678   15.61765  1.000 19.99508  ? 161 PHE A O    1 
ATOM   2627 C  CB   . PHE A 1 169 ? 17.35380  -2.53353  15.46291  1.000 16.55288  ? 161 PHE A CB   1 
ATOM   2628 C  CG   . PHE A 1 169 ? 17.28277  -3.98414  15.07806  1.000 18.69508  ? 161 PHE A CG   1 
ATOM   2629 C  CD1  . PHE A 1 169 ? 18.26137  -4.54181  14.28771  1.000 19.08626  ? 161 PHE A CD1  1 
ATOM   2630 C  CD2  . PHE A 1 169 ? 16.24966  -4.78983  15.51561  1.000 18.11872  ? 161 PHE A CD2  1 
ATOM   2631 C  CE1  . PHE A 1 169 ? 18.20678  -5.88186  13.91461  1.000 17.73567  ? 161 PHE A CE1  1 
ATOM   2632 C  CE2  . PHE A 1 169 ? 16.19529  -6.13076  15.16972  1.000 20.33336  ? 161 PHE A CE2  1 
ATOM   2633 C  CZ   . PHE A 1 169 ? 17.16840  -6.67522  14.35126  1.000 20.04207  ? 161 PHE A CZ   1 
ATOM   2634 H  H    . PHE A 1 169 ? 17.71818  -2.86516  18.05623  1.000 24.66861  ? 161 PHE A H    1 
ATOM   2635 H  HA   . PHE A 1 169 ? 19.36082  -2.44190  15.95049  1.000 23.65422  ? 161 PHE A HA   1 
ATOM   2636 H  HB2  . PHE A 1 169 ? 16.52677  -2.30756  15.91661  1.000 19.84026  ? 161 PHE A HB2  1 
ATOM   2637 H  HB3  . PHE A 1 169 ? 17.43698  -2.01535  14.64715  1.000 19.84026  ? 161 PHE A HB3  1 
ATOM   2638 H  HD1  . PHE A 1 169 ? 18.97084  -4.01489  13.99805  1.000 22.88033  ? 161 PHE A HD1  1 
ATOM   2639 H  HD2  . PHE A 1 169 ? 15.58067  -4.42711  16.05021  1.000 21.71928  ? 161 PHE A HD2  1 
ATOM   2640 H  HE1  . PHE A 1 169 ? 18.87048  -6.24118  13.37122  1.000 21.25962  ? 161 PHE A HE1  1 
ATOM   2641 H  HE2  . PHE A 1 169 ? 15.50389  -6.66501  15.48820  1.000 24.37684  ? 161 PHE A HE2  1 
ATOM   2642 H  HZ   . PHE A 1 169 ? 17.12218  -7.56887  14.09796  1.000 24.02730  ? 161 PHE A HZ   1 
ATOM   2643 N  N    . CYS A 1 170 ? 18.12709  -0.16159  17.72107  1.000 20.79198  ? 162 CYS A N    1 
ATOM   2644 C  CA   . CYS A 1 170 ? 17.85373  1.26155   17.85367  1.000 20.73669  ? 162 CYS A CA   1 
ATOM   2645 C  C    . CYS A 1 170 ? 18.81256  2.00852   18.77224  1.000 21.92203  ? 162 CYS A C    1 
ATOM   2646 O  O    . CYS A 1 170 ? 18.70488  3.23163   18.87975  1.000 30.36660  ? 162 CYS A O    1 
ATOM   2647 C  CB   . CYS A 1 170 ? 16.41801  1.46147   18.35499  1.000 16.94197  ? 162 CYS A CB   1 
ATOM   2648 S  SG   . CYS A 1 170 ? 15.15354  0.70186   17.32205  1.000 20.25847  ? 162 CYS A SG   1 
ATOM   2649 H  H    . CYS A 1 170 ? 18.00009  -0.61536  18.44049  1.000 24.92718  ? 162 CYS A H    1 
ATOM   2650 H  HA   . CYS A 1 170 ? 17.94451  1.66132   16.97455  1.000 24.86084  ? 162 CYS A HA   1 
ATOM   2651 H  HB2  . CYS A 1 170 ? 16.34374  1.07449   19.24135  1.000 20.30718  ? 162 CYS A HB2  1 
ATOM   2652 H  HB3  . CYS A 1 170 ? 16.23352  2.41305   18.39191  1.000 20.30718  ? 162 CYS A HB3  1 
ATOM   2653 H  HG   . CYS A 1 170 ? 14.07694  0.89851   17.81426  1.000 24.28697  ? 162 CYS A HG   1 
ATOM   2654 N  N    . LEU A 1 171 ? 19.74208  1.32727   19.43566  1.000 27.41550  ? 163 LEU A N    1 
ATOM   2655 C  CA   . LEU A 1 171 ? 20.60499  1.98787   20.40789  1.000 29.60924  ? 163 LEU A CA   1 
ATOM   2656 C  C    . LEU A 1 171 ? 22.02118  2.21832   19.90194  1.000 36.09586  ? 163 LEU A C    1 
ATOM   2657 O  O    . LEU A 1 171 ? 22.70309  3.11340   20.40802  1.000 44.11129  ? 163 LEU A O    1 
ATOM   2658 C  CB   . LEU A 1 171 ? 20.67436  1.17037   21.70274  1.000 20.78707  ? 163 LEU A CB   1 
ATOM   2659 C  CG   . LEU A 1 171 ? 19.33763  0.89134   22.38427  1.000 20.86050  ? 163 LEU A CG   1 
ATOM   2660 C  CD1  . LEU A 1 171 ? 19.56134  0.33649   23.78498  1.000 23.12256  ? 163 LEU A CD1  1 
ATOM   2661 C  CD2  . LEU A 1 171 ? 18.45634  2.13499   22.44746  1.000 28.70126  ? 163 LEU A CD2  1 
ATOM   2662 H  H    . LEU A 1 171 ? 19.89143  0.48571   19.34048  1.000 32.87541  ? 163 LEU A H    1 
ATOM   2663 H  HA   . LEU A 1 171 ? 20.21925  2.85245   20.61908  1.000 35.50790  ? 163 LEU A HA   1 
ATOM   2664 H  HB2  . LEU A 1 171 ? 21.07819  0.31242   21.49841  1.000 24.92130  ? 163 LEU A HB2  1 
ATOM   2665 H  HB3  . LEU A 1 171 ? 21.22595  1.65392   22.33743  1.000 24.92130  ? 163 LEU A HB3  1 
ATOM   2666 H  HG   . LEU A 1 171 ? 18.86555  0.23039   21.85400  1.000 25.00941  ? 163 LEU A HG   1 
ATOM   2667 H  HD11 . LEU A 1 171 ? 18.70056  0.18079   24.20418  1.000 27.72388  ? 163 LEU A HD11 1 
ATOM   2668 H  HD12 . LEU A 1 171 ? 20.05305  -0.49709  23.71965  1.000 27.72388  ? 163 LEU A HD12 1 
ATOM   2669 H  HD13 . LEU A 1 171 ? 20.06955  0.98063   24.30237  1.000 27.72388  ? 163 LEU A HD13 1 
ATOM   2670 H  HD21 . LEU A 1 171 ? 17.65743  1.93029   22.95809  1.000 34.41832  ? 163 LEU A HD21 1 
ATOM   2671 H  HD22 . LEU A 1 171 ? 18.94998  2.85031   22.87821  1.000 34.41832  ? 163 LEU A HD22 1 
ATOM   2672 H  HD23 . LEU A 1 171 ? 18.21431  2.39671   21.54534  1.000 34.41832  ? 163 LEU A HD23 1 
ATOM   2673 N  N    . ARG A 1 172 ? 22.47674  1.44644   18.92193  1.000 38.94378  ? 164 ARG A N    1 
ATOM   2674 C  CA   . ARG A 1 172 ? 23.81753  1.62209   18.38908  1.000 41.49135  ? 164 ARG A CA   1 
ATOM   2675 C  C    . ARG A 1 172 ? 23.90714  2.91293   17.58542  1.000 37.19057  ? 164 ARG A C    1 
ATOM   2676 O  O    . ARG A 1 172 ? 22.91097  3.43579   17.08686  1.000 40.58743  ? 164 ARG A O    1 
ATOM   2677 C  CB   . ARG A 1 172 ? 24.20397  0.44579   17.49324  1.000 51.56692  ? 164 ARG A CB   1 
ATOM   2678 C  CG   . ARG A 1 172 ? 24.40783  -0.86206  18.22870  1.000 61.87173  ? 164 ARG A CG   1 
ATOM   2679 C  CD   . ARG A 1 172 ? 25.07129  -1.90671  17.33290  1.000 68.36372  ? 164 ARG A CD   1 
ATOM   2680 N  NE   . ARG A 1 172 ? 26.26176  -2.47533  17.95735  1.000 79.17529  ? 164 ARG A NE   1 
ATOM   2681 C  CZ   . ARG A 1 172 ? 27.48759  -2.38058  17.45423  1.000 72.39305  ? 164 ARG A CZ   1 
ATOM   2682 N  NH1  . ARG A 1 172 ? 27.69149  -1.74705  16.30606  1.000 57.93538  ? 164 ARG A NH1  1 
ATOM   2683 N  NH2  . ARG A 1 172 ? 28.51455  -2.92482  18.09354  1.000 72.06686  ? 164 ARG A NH2  1 
ATOM   2684 H  H    . ARG A 1 172 ? 22.02816  0.81434   18.54933  1.000 46.70934  ? 164 ARG A H    1 
ATOM   2685 H  HA   . ARG A 1 172 ? 24.44603  1.66587   19.12663  1.000 49.76644  ? 164 ARG A HA   1 
ATOM   2686 H  HB2  . ARG A 1 172 ? 23.49861  0.30879   16.84163  1.000 61.85711  ? 164 ARG A HB2  1 
ATOM   2687 H  HB3  . ARG A 1 172 ? 25.03523  0.66100   17.04202  1.000 61.85711  ? 164 ARG A HB3  1 
ATOM   2688 H  HG2  . ARG A 1 172 ? 24.97887  -0.71279  18.99846  1.000 74.22289  ? 164 ARG A HG2  1 
ATOM   2689 H  HG3  . ARG A 1 172 ? 23.54796  -1.20742  18.51550  1.000 74.22289  ? 164 ARG A HG3  1 
ATOM   2690 H  HD2  . ARG A 1 172 ? 24.44419  -2.62667  17.16174  1.000 82.01328  ? 164 ARG A HD2  1 
ATOM   2691 H  HD3  . ARG A 1 172 ? 25.33522  -1.49094  16.49722  1.000 82.01328  ? 164 ARG A HD3  1 
ATOM   2692 H  HE   . ARG A 1 172 ? 26.16322  -2.89920  18.69912  1.000 94.98716  ? 164 ARG A HE   1 
ATOM   2693 H  HH11 . ARG A 1 172 ? 27.02881  -1.39608  15.88503  1.000 69.49927  ? 164 ARG A HH11 1 
ATOM   2694 H  HH12 . ARG A 1 172 ? 28.48630  -1.68748  15.98306  1.000 69.49927  ? 164 ARG A HH12 1 
ATOM   2695 H  HH21 . ARG A 1 172 ? 28.38772  -3.34035  18.83573  1.000 86.45705  ? 164 ARG A HH21 1 
ATOM   2696 H  HH22 . ARG A 1 172 ? 29.30719  -2.86215  17.76582  1.000 86.45705  ? 164 ARG A HH22 1 
ATOM   2697 N  N    . GLU A 1 173 ? 25.12665  3.43405   17.46594  1.000 43.84994  ? 165 GLU A N    1 
ATOM   2698 C  CA   . GLU A 1 173 ? 25.32961  4.62070   16.64253  1.000 47.49706  ? 165 GLU A CA   1 
ATOM   2699 C  C    . GLU A 1 173 ? 25.20494  4.30495   15.15610  1.000 37.97338  ? 165 GLU A C    1 
ATOM   2700 O  O    . GLU A 1 173 ? 24.72843  5.13931   14.37641  1.000 33.05369  ? 165 GLU A O    1 
ATOM   2701 C  CB   . GLU A 1 173 ? 26.70735  5.22360   16.90839  1.000 55.62880  ? 165 GLU A CB   1 
ATOM   2702 C  CG   . GLU A 1 173 ? 26.95413  5.70712   18.32076  1.000 85.33859  ? 165 GLU A CG   1 
ATOM   2703 C  CD   . GLU A 1 173 ? 28.41716  6.04182   18.55727  1.000 85.00936  ? 165 GLU A CD   1 
ATOM   2704 O  OE1  . GLU A 1 173 ? 29.13092  5.19809   19.14211  1.000 72.63033  ? 165 GLU A OE1  1 
ATOM   2705 O  OE2  . GLU A 1 173 ? 28.85081  7.14494   18.15309  1.000 78.72748  ? 165 GLU A OE2  1 
ATOM   2706 H  H    . GLU A 1 173 ? 25.83623  3.12682   17.84238  1.000 52.59674  ? 165 GLU A H    1 
ATOM   2707 H  HA   . GLU A 1 173 ? 24.65229  5.27184   16.88369  1.000 56.97328  ? 165 GLU A HA   1 
ATOM   2708 H  HB2  . GLU A 1 173 ? 27.37668  4.54877   16.71475  1.000 66.73137  ? 165 GLU A HB2  1 
ATOM   2709 H  HB3  . GLU A 1 173 ? 26.82427  5.98542   16.31944  1.000 66.73137  ? 165 GLU A HB3  1 
ATOM   2710 H  HG2  . GLU A 1 173 ? 26.42989  6.50745   18.48060  1.000 102.38312 ? 165 GLU A HG2  1 
ATOM   2711 H  HG3  . GLU A 1 173 ? 26.69684  5.01162   18.94605  1.000 102.38312 ? 165 GLU A HG3  1 
ATOM   2712 N  N    . GLN A 1 174 ? 25.63880  3.12164   14.74457  1.000 35.33701  ? 166 GLN A N    1 
ATOM   2713 C  CA   . GLN A 1 174 ? 25.73185  2.77492   13.33235  1.000 43.17098  ? 166 GLN A CA   1 
ATOM   2714 C  C    . GLN A 1 174 ? 24.45859  2.05731   12.89904  1.000 31.76746  ? 166 GLN A C    1 
ATOM   2715 O  O    . GLN A 1 174 ? 24.24371  0.89303   13.24202  1.000 36.43607  ? 166 GLN A O    1 
ATOM   2716 C  CB   . GLN A 1 174 ? 26.96750  1.91353   13.08626  1.000 45.04605  ? 166 GLN A CB   1 
ATOM   2717 C  CG   . GLN A 1 174 ? 28.26672  2.70544   12.98789  1.000 58.28024  ? 166 GLN A CG   1 
ATOM   2718 C  CD   . GLN A 1 174 ? 29.31625  2.26457   14.00850  1.000 76.06579  ? 166 GLN A CD   1 
ATOM   2719 O  OE1  . GLN A 1 174 ? 29.12202  1.29234   14.74536  1.000 71.52644  ? 166 GLN A OE1  1 
ATOM   2720 N  NE2  . GLN A 1 174 ? 30.43624  2.98475   14.05333  1.000 72.85603  ? 166 GLN A NE2  1 
ATOM   2721 H  H    . GLN A 1 174 ? 25.88970  2.49114   15.27290  1.000 42.38122  ? 166 GLN A H    1 
ATOM   2722 H  HA   . GLN A 1 174 ? 25.80410  3.58634   12.80577  1.000 51.78199  ? 166 GLN A HA   1 
ATOM   2723 H  HB2  . GLN A 1 174 ? 27.05962  1.28552   13.81976  1.000 54.03208  ? 166 GLN A HB2  1 
ATOM   2724 H  HB3  . GLN A 1 174 ? 26.85057  1.43370   12.25140  1.000 54.03208  ? 166 GLN A HB3  1 
ATOM   2725 H  HG2  . GLN A 1 174 ? 28.64269  2.58474   12.10191  1.000 69.91309  ? 166 GLN A HG2  1 
ATOM   2726 H  HG3  . GLN A 1 174 ? 28.07589  3.64387   13.14228  1.000 69.91309  ? 166 GLN A HG3  1 
ATOM   2727 H  HE21 . GLN A 1 174 ? 30.53717  3.65613   13.52544  1.000 87.40405  ? 166 GLN A HE21 1 
ATOM   2728 H  HE22 . GLN A 1 174 ? 31.05825  2.77825   14.61015  1.000 87.40405  ? 166 GLN A HE22 1 
ATOM   2729 N  N    . LEU A 1 175 ? 23.61267  2.75778   12.15059  1.000 27.84233  ? 167 LEU A N    1 
ATOM   2730 C  CA   . LEU A 1 175 ? 22.42493  2.16228   11.55517  1.000 21.91889  ? 167 LEU A CA   1 
ATOM   2731 C  C    . LEU A 1 175 ? 22.71932  1.50866   10.21197  1.000 21.20585  ? 167 LEU A C    1 
ATOM   2732 O  O    . LEU A 1 175 ? 22.04692  0.54189   9.83181   1.000 18.70530  ? 167 LEU A O    1 
ATOM   2733 C  CB   . LEU A 1 175 ? 21.35296  3.23824   11.36856  1.000 27.26737  ? 167 LEU A CB   1 
ATOM   2734 C  CG   . LEU A 1 175 ? 20.91894  3.98431   12.63616  1.000 26.06743  ? 167 LEU A CG   1 
ATOM   2735 C  CD1  . LEU A 1 175 ? 20.10757  5.22798   12.28723  1.000 19.12753  ? 167 LEU A CD1  1 
ATOM   2736 C  CD2  . LEU A 1 175 ? 20.12909  3.05477   13.55248  1.000 18.90245  ? 167 LEU A CD2  1 
ATOM   2737 H  H    . LEU A 1 175 ? 23.70672  3.59340   11.97030  1.000 33.38761  ? 167 LEU A H    1 
ATOM   2738 H  HA   . LEU A 1 175 ? 22.07315  1.48190   12.15035  1.000 26.27947  ? 167 LEU A HA   1 
ATOM   2739 H  HB2  . LEU A 1 175 ? 21.69499  3.90111   10.74847  1.000 32.69766  ? 167 LEU A HB2  1 
ATOM   2740 H  HB3  . LEU A 1 175 ? 20.56178  2.81561   10.99935  1.000 32.69766  ? 167 LEU A HB3  1 
ATOM   2741 H  HG   . LEU A 1 175 ? 21.70900  4.27956   13.11526  1.000 31.25772  ? 167 LEU A HG   1 
ATOM   2742 H  HD11 . LEU A 1 175 ? 19.84318  5.67299   13.10757  1.000 22.92984  ? 167 LEU A HD11 1 
ATOM   2743 H  HD12 . LEU A 1 175 ? 20.65519  5.82196   11.75039  1.000 22.92984  ? 167 LEU A HD12 1 
ATOM   2744 H  HD13 . LEU A 1 175 ? 19.32041  4.96142   11.78700  1.000 22.92984  ? 167 LEU A HD13 1 
ATOM   2745 H  HD21 . LEU A 1 175 ? 19.83886  3.55238   14.33289  1.000 22.65975  ? 167 LEU A HD21 1 
ATOM   2746 H  HD22 . LEU A 1 175 ? 19.35834  2.71629   13.07053  1.000 22.65975  ? 167 LEU A HD22 1 
ATOM   2747 H  HD23 . LEU A 1 175 ? 20.69958  2.31840   13.82303  1.000 22.65975  ? 167 LEU A HD23 1 
ATOM   2748 N  N    . TRP A 1 176 ? 23.69284  2.03185   9.47503   1.000 21.37831  ? 168 TRP A N    1 
ATOM   2749 C  CA   . TRP A 1 176 ? 24.13213  1.45114   8.21643   1.000 24.00137  ? 168 TRP A CA   1 
ATOM   2750 C  C    . TRP A 1 176 ? 25.59038  1.03365   8.33495   1.000 21.97980  ? 168 TRP A C    1 
ATOM   2751 O  O    . TRP A 1 176 ? 26.41547  1.77076   8.87790   1.000 29.86166  ? 168 TRP A O    1 
ATOM   2752 C  CB   . TRP A 1 176 ? 23.96448  2.44194   7.06013   1.000 19.87725  ? 168 TRP A CB   1 
ATOM   2753 C  CG   . TRP A 1 176 ? 22.55828  2.94154   6.90297   1.000 21.41479  ? 168 TRP A CG   1 
ATOM   2754 C  CD1  . TRP A 1 176 ? 22.07944  4.17223   7.25473   1.000 20.17944  ? 168 TRP A CD1  1 
ATOM   2755 C  CD2  . TRP A 1 176 ? 21.44218  2.22095   6.36020   1.000 19.35934  ? 168 TRP A CD2  1 
ATOM   2756 N  NE1  . TRP A 1 176 ? 20.74061  4.26216   6.95566   1.000 19.54310  ? 168 TRP A NE1  1 
ATOM   2757 C  CE2  . TRP A 1 176 ? 20.32571  3.07839   6.40841   1.000 19.43768  ? 168 TRP A CE2  1 
ATOM   2758 C  CE3  . TRP A 1 176 ? 21.28139  0.94231   5.83177   1.000 18.72307  ? 168 TRP A CE3  1 
ATOM   2759 C  CZ2  . TRP A 1 176 ? 19.06436  2.69116   5.95167   1.000 16.07149  ? 168 TRP A CZ2  1 
ATOM   2760 C  CZ3  . TRP A 1 176 ? 20.02858  0.56444   5.37086   1.000 21.80084  ? 168 TRP A CZ3  1 
ATOM   2761 C  CH2  . TRP A 1 176 ? 18.93546  1.42827   5.45042   1.000 17.85243  ? 168 TRP A CH2  1 
ATOM   2762 H  H    . TRP A 1 176 ? 24.12482  2.74330   9.69145   1.000 25.63078  ? 168 TRP A H    1 
ATOM   2763 H  HA   . TRP A 1 176 ? 23.60191  0.66371   8.01716   1.000 28.77846  ? 168 TRP A HA   1 
ATOM   2764 H  HB2  . TRP A 1 176 ? 24.53671  3.20886   7.21914   1.000 23.82951  ? 168 TRP A HB2  1 
ATOM   2765 H  HB3  . TRP A 1 176 ? 24.21890  2.00404   6.23284   1.000 23.82951  ? 168 TRP A HB3  1 
ATOM   2766 H  HD1  . TRP A 1 176 ? 22.58571  4.85036   7.64038   1.000 24.19213  ? 168 TRP A HD1  1 
ATOM   2767 H  HE1  . TRP A 1 176 ? 20.24395  4.95114   7.09069   1.000 23.42853  ? 168 TRP A HE1  1 
ATOM   2768 H  HE3  . TRP A 1 176 ? 21.99983  0.35335   5.78875   1.000 22.44449  ? 168 TRP A HE3  1 
ATOM   2769 H  HZ2  . TRP A 1 176 ? 18.33907  3.27215   5.98766   1.000 19.26260  ? 168 TRP A HZ2  1 
ATOM   2770 H  HZ3  . TRP A 1 176 ? 19.91498  -0.28146  5.00148   1.000 26.13782  ? 168 TRP A HZ3  1 
ATOM   2771 H  HH2  . TRP A 1 176 ? 18.10254  1.13762   5.15601   1.000 21.39972  ? 168 TRP A HH2  1 
ATOM   2772 N  N    . GLY A 1 177 ? 25.91174  -0.14980  7.81709   1.000 26.22436  ? 169 GLY A N    1 
ATOM   2773 C  CA   . GLY A 1 177 ? 27.30108  -0.56426  7.76507   1.000 25.33157  ? 169 GLY A CA   1 
ATOM   2774 C  C    . GLY A 1 177 ? 28.06976  -0.02420  6.58074   1.000 26.85678  ? 169 GLY A C    1 
ATOM   2775 O  O    . GLY A 1 177 ? 29.30350  -0.06288  6.59142   1.000 26.63878  ? 169 GLY A O    1 
ATOM   2776 H  H    . GLY A 1 177 ? 25.35127  -0.71769  7.49619   1.000 31.44604  ? 169 GLY A H    1 
ATOM   2777 H  HA2  . GLY A 1 177 ? 27.74746  -0.26332  8.57197   1.000 30.37469  ? 169 GLY A HA2  1 
ATOM   2778 H  HA3  . GLY A 1 177 ? 27.33710  -1.53283  7.72674   1.000 30.37469  ? 169 GLY A HA3  1 
ATOM   2779 N  N    . TRP A 1 178 ? 27.36745  0.48241   5.56793   1.000 26.70994  ? 170 TRP A N    1 
ATOM   2780 C  CA   . TRP A 1 178 ? 27.98562  1.00806   4.35783   1.000 25.22743  ? 170 TRP A CA   1 
ATOM   2781 C  C    . TRP A 1 178 ? 26.95410  1.88545   3.66274   1.000 27.26998  ? 170 TRP A C    1 
ATOM   2782 O  O    . TRP A 1 178 ? 25.79014  1.49374   3.53367   1.000 23.51129  ? 170 TRP A O    1 
ATOM   2783 C  CB   . TRP A 1 178 ? 28.45846  -0.13489  3.44337   1.000 32.86965  ? 170 TRP A CB   1 
ATOM   2784 C  CG   . TRP A 1 178 ? 29.01524  0.30672   2.11989   1.000 33.44405  ? 170 TRP A CG   1 
ATOM   2785 C  CD1  . TRP A 1 178 ? 30.30384  0.66329   1.84943   1.000 37.43280  ? 170 TRP A CD1  1 
ATOM   2786 C  CD2  . TRP A 1 178 ? 28.29743  0.43185   0.88502   1.000 31.67858  ? 170 TRP A CD2  1 
ATOM   2787 N  NE1  . TRP A 1 178 ? 30.43219  1.00325   0.52459   1.000 31.67274  ? 170 TRP A NE1  1 
ATOM   2788 C  CE2  . TRP A 1 178 ? 29.21338  0.87711   -0.08732  1.000 36.08876  ? 170 TRP A CE2  1 
ATOM   2789 C  CE3  . TRP A 1 178 ? 26.96935  0.21311   0.50897   1.000 30.61666  ? 170 TRP A CE3  1 
ATOM   2790 C  CZ2  . TRP A 1 178 ? 28.84688  1.10360   -1.41243  1.000 30.18699  ? 170 TRP A CZ2  1 
ATOM   2791 C  CZ3  . TRP A 1 178 ? 26.60735  0.43646   -0.81423  1.000 39.47129  ? 170 TRP A CZ3  1 
ATOM   2792 C  CH2  . TRP A 1 178 ? 27.54353  0.87726   -1.75525  1.000 41.07897  ? 170 TRP A CH2  1 
ATOM   2793 H  H    . TRP A 1 178 ? 26.50900  0.53328   5.55935   1.000 32.02874  ? 170 TRP A H    1 
ATOM   2794 H  HA   . TRP A 1 178 ? 28.76084  1.55034   4.57199   1.000 30.24972  ? 170 TRP A HA   1 
ATOM   2795 H  HB2  . TRP A 1 178 ? 29.15562  -0.62857  3.90289   1.000 39.42039  ? 170 TRP A HB2  1 
ATOM   2796 H  HB3  . TRP A 1 178 ? 27.70383  -0.71693  3.26265   1.000 39.42039  ? 170 TRP A HB3  1 
ATOM   2797 H  HD1  . TRP A 1 178 ? 30.99505  0.67461   2.47153   1.000 44.89617  ? 170 TRP A HD1  1 
ATOM   2798 H  HE1  . TRP A 1 178 ? 31.15998  1.25456   0.14149   1.000 37.98409  ? 170 TRP A HE1  1 
ATOM   2799 H  HE3  . TRP A 1 178 ? 26.34112  -0.07577  1.13088   1.000 36.71680  ? 170 TRP A HE3  1 
ATOM   2800 H  HZ2  . TRP A 1 178 ? 29.46644  1.39796   -2.04044  1.000 36.20120  ? 170 TRP A HZ2  1 
ATOM   2801 H  HZ3  . TRP A 1 178 ? 25.72771  0.29033   -1.07839  1.000 47.34236  ? 170 TRP A HZ3  1 
ATOM   2802 H  HH2  . TRP A 1 178 ? 27.27307  1.01947   -2.63362  1.000 49.27157  ? 170 TRP A HH2  1 
ATOM   2803 N  N    . GLN A 1 179 ? 27.37129  3.07447   3.24137   1.000 28.36183  ? 171 GLN A N    1 
ATOM   2804 C  CA   . GLN A 1 179 ? 26.47855  3.97716   2.53007   1.000 26.80721  ? 171 GLN A CA   1 
ATOM   2805 C  C    . GLN A 1 179 ? 27.31620  4.94436   1.71425   1.000 30.55474  ? 171 GLN A C    1 
ATOM   2806 O  O    . GLN A 1 179 ? 28.43128  5.29565   2.10275   1.000 28.30250  ? 171 GLN A O    1 
ATOM   2807 C  CB   . GLN A 1 179 ? 25.56195  4.74663   3.48349   1.000 23.91590  ? 171 GLN A CB   1 
ATOM   2808 C  CG   . GLN A 1 179 ? 26.20695  5.92658   4.17319   1.000 30.05761  ? 171 GLN A CG   1 
ATOM   2809 C  CD   . GLN A 1 179 ? 25.46820  6.30617   5.45420   1.000 29.34897  ? 171 GLN A CD   1 
ATOM   2810 O  OE1  . GLN A 1 179 ? 24.63430  7.21069   5.45925   1.000 40.01643  ? 171 GLN A OE1  1 
ATOM   2811 N  NE2  . GLN A 1 179 ? 25.77385  5.60989   6.54586   1.000 40.77728  ? 171 GLN A NE2  1 
ATOM   2812 H  H    . GLN A 1 179 ? 28.16686  3.38043   3.35567   1.000 34.01101  ? 171 GLN A H    1 
ATOM   2813 H  HA   . GLN A 1 179 ? 25.91980  3.46232   1.92705   1.000 32.14546  ? 171 GLN A HA   1 
ATOM   2814 H  HB2  . GLN A 1 179 ? 24.80536  5.08273   2.97801   1.000 28.67589  ? 171 GLN A HB2  1 
ATOM   2815 H  HB3  . GLN A 1 179 ? 25.25569  4.13770   4.17365   1.000 28.67589  ? 171 GLN A HB3  1 
ATOM   2816 H  HG2  . GLN A 1 179 ? 27.12148  5.70107   4.40487   1.000 36.04595  ? 171 GLN A HG2  1 
ATOM   2817 H  HG3  . GLN A 1 179 ? 26.19476  6.69158   3.57693   1.000 36.04595  ? 171 GLN A HG3  1 
ATOM   2818 H  HE21 . GLN A 1 179 ? 26.36111  4.98291   6.50557   1.000 48.90955  ? 171 GLN A HE21 1 
ATOM   2819 H  HE22 . GLN A 1 179 ? 25.38416  5.78677   7.29182   1.000 48.90955  ? 171 GLN A HE22 1 
ATOM   2820 N  N    . GLY A 1 180 ? 26.76490  5.36465   0.57957   1.000 33.72755  ? 172 GLY A N    1 
ATOM   2821 C  CA   . GLY A 1 180 ? 27.49050  6.20171   -0.35673  1.000 29.71979  ? 172 GLY A CA   1 
ATOM   2822 C  C    . GLY A 1 180 ? 26.52837  6.93183   -1.26489  1.000 29.17302  ? 172 GLY A C    1 
ATOM   2823 O  O    . GLY A 1 180 ? 25.33966  6.60864   -1.34737  1.000 27.92547  ? 172 GLY A O    1 
ATOM   2824 H  H    . GLY A 1 180 ? 25.96411  5.17495   0.32987   1.000 40.44987  ? 172 GLY A H    1 
ATOM   2825 H  HA2  . GLY A 1 180 ? 28.02113  6.85370   0.12726   1.000 35.64055  ? 172 GLY A HA2  1 
ATOM   2826 H  HA3  . GLY A 1 180 ? 28.08001  5.65468   -0.89906  1.000 35.64055  ? 172 GLY A HA3  1 
ATOM   2827 N  N    . HIS A 1 181 ? 27.06878  7.93553   -1.95250  1.000 22.77967  ? 173 HIS A N    1 
ATOM   2828 C  CA   . HIS A 1 181 ? 26.27298  8.78922   -2.82056  1.000 24.89089  ? 173 HIS A CA   1 
ATOM   2829 C  C    . HIS A 1 181 ? 27.10318  9.19340   -4.03339  1.000 29.09145  ? 173 HIS A C    1 
ATOM   2830 O  O    . HIS A 1 181 ? 28.33693  9.18053   -4.00524  1.000 30.74312  ? 173 HIS A O    1 
ATOM   2831 C  CB   . HIS A 1 181 ? 25.77463  10.03672  -2.07725  1.000 25.34638  ? 173 HIS A CB   1 
ATOM   2832 C  CG   . HIS A 1 181 ? 24.99627  9.73661   -0.83053  1.000 30.69033  ? 173 HIS A CG   1 
ATOM   2833 N  ND1  . HIS A 1 181 ? 23.62191  9.63400   -0.81826  1.000 30.74156  ? 173 HIS A ND1  1 
ATOM   2834 C  CD2  . HIS A 1 181 ? 25.39873  9.52056   0.44496   1.000 29.68725  ? 173 HIS A CD2  1 
ATOM   2835 C  CE1  . HIS A 1 181 ? 23.21035  9.37851   0.41094   1.000 30.08885  ? 173 HIS A CE1  1 
ATOM   2836 N  NE2  . HIS A 1 181 ? 24.26951  9.29689   1.19569   1.000 28.82137  ? 173 HIS A NE2  1 
ATOM   2837 H  H    . HIS A 1 181 ? 27.90328  8.14227   -1.93099  1.000 27.31241  ? 173 HIS A H    1 
ATOM   2838 H  HA   . HIS A 1 181 ? 25.50395  8.28958   -3.13656  1.000 29.84588  ? 173 HIS A HA   1 
ATOM   2839 H  HB2  . HIS A 1 181 ? 26.54131  10.57414  -1.82370  1.000 30.39247  ? 173 HIS A HB2  1 
ATOM   2840 H  HB3  . HIS A 1 181 ? 25.19708  10.54184  -2.67071  1.000 30.39247  ? 173 HIS A HB3  1 
ATOM   2841 H  HD2  . HIS A 1 181 ? 26.27562  9.52312   0.75472   1.000 35.60151  ? 173 HIS A HD2  1 
ATOM   2842 H  HE1  . HIS A 1 181 ? 22.32568  9.27397   0.67804   1.000 36.08343  ? 173 HIS A HE1  1 
ATOM   2843 N  N    . PHE A 1 182 ? 26.40425  9.54440   -5.10918  1.000 27.21114  ? 174 PHE A N    1 
ATOM   2844 C  CA   . PHE A 1 182 ? 27.04809  10.01344  -6.32685  1.000 33.42270  ? 174 PHE A CA   1 
ATOM   2845 C  C    . PHE A 1 182 ? 26.08724  10.93848  -7.05931  1.000 34.23657  ? 174 PHE A C    1 
ATOM   2846 O  O    . PHE A 1 182 ? 24.87566  10.70092  -7.06717  1.000 30.58276  ? 174 PHE A O    1 
ATOM   2847 C  CB   . PHE A 1 182 ? 27.46352  8.85037   -7.22971  1.000 33.80209  ? 174 PHE A CB   1 
ATOM   2848 C  CG   . PHE A 1 182 ? 28.54931  9.20923   -8.19931  1.000 44.51555  ? 174 PHE A CG   1 
ATOM   2849 C  CD1  . PHE A 1 182 ? 29.87289  9.25767   -7.79398  1.000 48.86985  ? 174 PHE A CD1  1 
ATOM   2850 C  CD2  . PHE A 1 182 ? 28.24707  9.50882   -9.51644  1.000 46.19959  ? 174 PHE A CD2  1 
ATOM   2851 C  CE1  . PHE A 1 182 ? 30.87494  9.59368   -8.68935  1.000 51.03567  ? 174 PHE A CE1  1 
ATOM   2852 C  CE2  . PHE A 1 182 ? 29.24468  9.85148   -10.41150 1.000 42.94216  ? 174 PHE A CE2  1 
ATOM   2853 C  CZ   . PHE A 1 182 ? 30.55856  9.89476   -9.99429  1.000 40.73416  ? 174 PHE A CZ   1 
ATOM   2854 H  H    . PHE A 1 182 ? 25.54597  9.51868   -5.15713  1.000 32.63018  ? 174 PHE A H    1 
ATOM   2855 H  HA   . PHE A 1 182 ? 27.84721  10.51546  -6.10262  1.000 40.08405  ? 174 PHE A HA   1 
ATOM   2856 H  HB2  . PHE A 1 182 ? 27.78770  8.12345   -6.67527  1.000 40.53932  ? 174 PHE A HB2  1 
ATOM   2857 H  HB3  . PHE A 1 182 ? 26.69217  8.55927   -7.74077  1.000 40.53932  ? 174 PHE A HB3  1 
ATOM   2858 H  HD1  . PHE A 1 182 ? 30.09113  9.06251   -6.91127  1.000 58.62063  ? 174 PHE A HD1  1 
ATOM   2859 H  HD2  . PHE A 1 182 ? 27.36283  9.47940   -9.80309  1.000 55.41632  ? 174 PHE A HD2  1 
ATOM   2860 H  HE1  . PHE A 1 182 ? 31.76129  9.61579   -8.40866  1.000 61.21961  ? 174 PHE A HE1  1 
ATOM   2861 H  HE2  . PHE A 1 182 ? 29.02959  10.05246  -11.29369 1.000 51.50740  ? 174 PHE A HE2  1 
ATOM   2862 H  HZ   . PHE A 1 182 ? 31.23004  10.12719  -10.59429 1.000 48.85780  ? 174 PHE A HZ   1 
ATOM   2863 N  N    . ASN A 1 183 ? 26.62862  11.98859  -7.66278  1.000 32.98348  ? 175 ASN A N    1 
ATOM   2864 C  CA   . ASN A 1 183 ? 25.80144  13.02601  -8.28253  1.000 38.49337  ? 175 ASN A CA   1 
ATOM   2865 C  C    . ASN A 1 183 ? 24.78336  13.44974  -7.22711  1.000 30.94461  ? 175 ASN A C    1 
ATOM   2866 O  O    . ASN A 1 183 ? 25.06118  13.38666  -6.02685  1.000 39.65944  ? 175 ASN A O    1 
ATOM   2867 C  CB   . ASN A 1 183 ? 25.21529  12.51862  -9.58517  1.000 42.43099  ? 175 ASN A CB   1 
ATOM   2868 C  CG   . ASN A 1 183 ? 26.29177  12.26944  -10.64500 1.000 43.20692  ? 175 ASN A CG   1 
ATOM   2869 O  OD1  . ASN A 1 183 ? 27.38309  12.83451  -10.58238 1.000 45.57482  ? 175 ASN A OD1  1 
ATOM   2870 N  ND2  . ASN A 1 183 ? 25.99067  11.41712  -11.61041 1.000 33.94624  ? 175 ASN A ND2  1 
ATOM   2871 H  H    . ASN A 1 183 ? 27.47472  12.12750  -7.72920  1.000 39.55698  ? 175 ASN A H    1 
ATOM   2872 H  HA   . ASN A 1 183 ? 26.34730  13.79486  -8.51014  1.000 46.16886  ? 175 ASN A HA   1 
ATOM   2873 H  HB2  . ASN A 1 183 ? 24.75263  11.68192  -9.42153  1.000 50.89400  ? 175 ASN A HB2  1 
ATOM   2874 H  HB3  . ASN A 1 183 ? 24.59503  13.17811  -9.93339  1.000 50.89400  ? 175 ASN A HB3  1 
ATOM   2875 H  HD21 . ASN A 1 183 ? 26.56466  11.24620  -12.22760 1.000 40.71230  ? 175 ASN A HD21 1 
ATOM   2876 H  HD22 . ASN A 1 183 ? 25.22089  11.03381  -11.62099 1.000 40.71230  ? 175 ASN A HD22 1 
ATOM   2877 N  N    . GLU A 1 184 ? 23.60219  13.88649  -7.64340  1.000 29.53534  ? 176 GLU A N    1 
ATOM   2878 C  CA   . GLU A 1 184 ? 22.53749  14.21379  -6.70494  1.000 31.52953  ? 176 GLU A CA   1 
ATOM   2879 C  C    . GLU A 1 184 ? 21.43696  13.15817  -6.63219  1.000 31.23725  ? 176 GLU A C    1 
ATOM   2880 O  O    . GLU A 1 184 ? 20.52284  13.29434  -5.80811  1.000 31.01012  ? 176 GLU A O    1 
ATOM   2881 C  CB   . GLU A 1 184 ? 21.89917  15.55884  -7.07520  1.000 31.78896  ? 176 GLU A CB   1 
ATOM   2882 C  CG   . GLU A 1 184 ? 22.87858  16.68382  -7.32566  1.000 53.52943  ? 176 GLU A CG   1 
ATOM   2883 C  CD   . GLU A 1 184 ? 22.51241  17.51205  -8.55474  1.000 56.70173  ? 176 GLU A CD   1 
ATOM   2884 O  OE1  . GLU A 1 184 ? 21.49720  18.25470  -8.49520  1.000 44.17567  ? 176 GLU A OE1  1 
ATOM   2885 O  OE2  . GLU A 1 184 ? 23.24154  17.40617  -9.57460  1.000 49.30017  ? 176 GLU A OE2  1 
ATOM   2886 H  H    . GLU A 1 184 ? 23.39165  14.00231  -8.46915  1.000 35.41922  ? 176 GLU A H    1 
ATOM   2887 H  HA   . GLU A 1 184 ? 22.92951  14.29520  -5.82143  1.000 37.81225  ? 176 GLU A HA   1 
ATOM   2888 H  HB2  . GLU A 1 184 ? 21.37995  15.43943  -7.88579  1.000 38.12356  ? 176 GLU A HB2  1 
ATOM   2889 H  HB3  . GLU A 1 184 ? 21.31977  15.83427  -6.34764  1.000 38.12356  ? 176 GLU A HB3  1 
ATOM   2890 H  HG2  . GLU A 1 184 ? 22.88728  17.27425  -6.55610  1.000 64.21212  ? 176 GLU A HG2  1 
ATOM   2891 H  HG3  . GLU A 1 184 ? 23.76232  16.30969  -7.46678  1.000 64.21212  ? 176 GLU A HG3  1 
ATOM   2892 N  N    . ASP A 1 185 ? 21.48492  12.12539  -7.47384  1.000 32.50242  ? 177 ASP A N    1 
ATOM   2893 C  CA   . ASP A 1 185 ? 20.37604  11.18674  -7.60942  1.000 29.11696  ? 177 ASP A CA   1 
ATOM   2894 C  C    . ASP A 1 185 ? 20.78683  9.74003   -7.36943  1.000 25.38438  ? 177 ASP A C    1 
ATOM   2895 O  O    . ASP A 1 185 ? 19.99512  8.82988   -7.64609  1.000 27.79151  ? 177 ASP A O    1 
ATOM   2896 C  CB   . ASP A 1 185 ? 19.74445  11.31688  -9.00015  1.000 24.44233  ? 177 ASP A CB   1 
ATOM   2897 C  CG   . ASP A 1 185 ? 20.72497  10.98816  -10.12055 1.000 37.33936  ? 177 ASP A CG   1 
ATOM   2898 O  OD1  . ASP A 1 185 ? 21.93478  11.23913  -9.93662  1.000 44.73244  ? 177 ASP A OD1  1 
ATOM   2899 O  OD2  . ASP A 1 185 ? 20.30193  10.46928  -11.18145 1.000 40.69901  ? 177 ASP A OD2  1 
ATOM   2900 H  H    . ASP A 1 185 ? 22.15618  11.94726  -7.98107  1.000 38.97971  ? 177 ASP A H    1 
ATOM   2901 H  HA   . ASP A 1 185 ? 19.70702  11.41249  -6.94434  1.000 34.91716  ? 177 ASP A HA   1 
ATOM   2902 H  HB2  . ASP A 1 185 ? 18.99533  10.70427  -9.06659  1.000 29.30761  ? 177 ASP A HB2  1 
ATOM   2903 H  HB3  . ASP A 1 185 ? 19.43921  12.22903  -9.12549  1.000 29.30761  ? 177 ASP A HB3  1 
ATOM   2904 N  N    . VAL A 1 186 ? 21.98894  9.49662   -6.85914  1.000 22.39114  ? 178 VAL A N    1 
ATOM   2905 C  CA   . VAL A 1 186 ? 22.46693  8.14404   -6.59507  1.000 29.07988  ? 178 VAL A CA   1 
ATOM   2906 C  C    . VAL A 1 186 ? 22.74962  8.01822   -5.10509  1.000 26.53145  ? 178 VAL A C    1 
ATOM   2907 O  O    . VAL A 1 186 ? 23.64621  8.68846   -4.57790  1.000 21.47181  ? 178 VAL A O    1 
ATOM   2908 C  CB   . VAL A 1 186 ? 23.71826  7.81015   -7.42151  1.000 23.43281  ? 178 VAL A CB   1 
ATOM   2909 C  CG1  . VAL A 1 186 ? 24.14497  6.37259   -7.17414  1.000 27.04424  ? 178 VAL A CG1  1 
ATOM   2910 C  CG2  . VAL A 1 186 ? 23.46598  8.05669   -8.90704  1.000 25.69937  ? 178 VAL A CG2  1 
ATOM   2911 H  H    . VAL A 1 186 ? 22.55574  10.11002  -6.65400  1.000 26.84618  ? 178 VAL A H    1 
ATOM   2912 H  HA   . VAL A 1 186 ? 21.76857  7.51063   -6.82308  1.000 34.87267  ? 178 VAL A HA   1 
ATOM   2913 H  HB   . VAL A 1 186 ? 24.44331  8.39221   -7.14510  1.000 28.09618  ? 178 VAL A HB   1 
ATOM   2914 H  HG11 . VAL A 1 186 ? 24.91001  6.16934   -7.73476  1.000 32.42989  ? 178 VAL A HG11 1 
ATOM   2915 H  HG12 . VAL A 1 186 ? 24.38333  6.27031   -6.23946  1.000 32.42989  ? 178 VAL A HG12 1 
ATOM   2916 H  HG13 . VAL A 1 186 ? 23.40756  5.78200   -7.39399  1.000 32.42989  ? 178 VAL A HG13 1 
ATOM   2917 H  HG21 . VAL A 1 186 ? 24.25696  7.80318   -9.40802  1.000 30.81605  ? 178 VAL A HG21 1 
ATOM   2918 H  HG22 . VAL A 1 186 ? 22.70856  7.52178   -9.19177  1.000 30.81605  ? 178 VAL A HG22 1 
ATOM   2919 H  HG23 . VAL A 1 186 ? 23.27590  8.99810   -9.04310  1.000 30.81605  ? 178 VAL A HG23 1 
ATOM   2920 N  N    . HIS A 1 187 ? 22.00199  7.14543   -4.42856  1.000 24.48503  ? 179 HIS A N    1 
ATOM   2921 C  CA   . HIS A 1 187 ? 22.08665  7.01852   -2.97468  1.000 19.78858  ? 179 HIS A CA   1 
ATOM   2922 C  C    . HIS A 1 187 ? 22.00314  5.55090   -2.59352  1.000 22.58804  ? 179 HIS A C    1 
ATOM   2923 O  O    . HIS A 1 187 ? 20.96116  4.91446   -2.79255  1.000 23.87812  ? 179 HIS A O    1 
ATOM   2924 C  CB   . HIS A 1 187 ? 20.97145  7.80822   -2.28437  1.000 24.31650  ? 179 HIS A CB   1 
ATOM   2925 C  CG   . HIS A 1 187 ? 20.75480  9.17711   -2.85408  1.000 32.50666  ? 179 HIS A CG   1 
ATOM   2926 N  ND1  . HIS A 1 187 ? 21.50965  10.26671  -2.47738  1.000 25.03513  ? 179 HIS A ND1  1 
ATOM   2927 C  CD2  . HIS A 1 187 ? 19.87896  9.63077   -3.78301  1.000 35.61761  ? 179 HIS A CD2  1 
ATOM   2928 C  CE1  . HIS A 1 187 ? 21.10810  11.33217  -3.14643  1.000 33.49669  ? 179 HIS A CE1  1 
ATOM   2929 N  NE2  . HIS A 1 187 ? 20.12680  10.97191  -3.95353  1.000 37.50462  ? 179 HIS A NE2  1 
ATOM   2930 H  H    . HIS A 1 187 ? 21.43417  6.61207   -4.79285  1.000 29.35884  ? 179 HIS A H    1 
ATOM   2931 H  HA   . HIS A 1 187 ? 22.94432  7.36128   -2.67834  1.000 23.72311  ? 179 HIS A HA   1 
ATOM   2932 H  HB2  . HIS A 1 187 ? 20.14032  7.31611   -2.37363  1.000 29.15661  ? 179 HIS A HB2  1 
ATOM   2933 H  HB3  . HIS A 1 187 ? 21.19718  7.91081   -1.34660  1.000 29.15661  ? 179 HIS A HB3  1 
ATOM   2934 H  HD2  . HIS A 1 187 ? 19.23137  9.12873   -4.22286  1.000 42.71794  ? 179 HIS A HD2  1 
ATOM   2935 H  HE1  . HIS A 1 187 ? 21.45701  12.19023  -3.06335  1.000 40.17284  ? 179 HIS A HE1  1 
ATOM   2936 N  N    . TYR A 1 188 ? 23.08930  5.02793   -2.03218  1.000 22.05291  ? 180 TYR A N    1 
ATOM   2937 C  CA   . TYR A 1 188 ? 23.20462  3.62351   -1.67522  1.000 17.01440  ? 180 TYR A CA   1 
ATOM   2938 C  C    . TYR A 1 188 ? 23.35343  3.46305   -0.16833  1.000 22.27076  ? 180 TYR A C    1 
ATOM   2939 O  O    . TYR A 1 188 ? 24.12070  4.19199   0.47558   1.000 19.70715  ? 180 TYR A O    1 
ATOM   2940 C  CB   . TYR A 1 188 ? 24.39921  2.97216   -2.37540  1.000 25.86825  ? 180 TYR A CB   1 
ATOM   2941 C  CG   . TYR A 1 188 ? 24.09572  2.45531   -3.77365  1.000 21.60884  ? 180 TYR A CG   1 
ATOM   2942 C  CD1  . TYR A 1 188 ? 23.78197  3.32658   -4.80263  1.000 23.92068  ? 180 TYR A CD1  1 
ATOM   2943 C  CD2  . TYR A 1 188 ? 24.12475  1.09820   -4.05804  1.000 27.21763  ? 180 TYR A CD2  1 
ATOM   2944 C  CE1  . TYR A 1 188 ? 23.50800  2.86633   -6.07556  1.000 25.90695  ? 180 TYR A CE1  1 
ATOM   2945 C  CE2  . TYR A 1 188 ? 23.85062  0.62077   -5.33242  1.000 21.18290  ? 180 TYR A CE2  1 
ATOM   2946 C  CZ   . TYR A 1 188 ? 23.53675  1.51199   -6.33583  1.000 22.88566  ? 180 TYR A CZ   1 
ATOM   2947 O  OH   . TYR A 1 188 ? 23.25258  1.06119   -7.60500  1.000 24.80074  ? 180 TYR A OH   1 
ATOM   2948 H  H    . TYR A 1 188 ? 23.79348  5.48417   -1.84357  1.000 26.44030  ? 180 TYR A H    1 
ATOM   2949 H  HA   . TYR A 1 188 ? 22.39313  3.16636   -1.94617  1.000 20.39409  ? 180 TYR A HA   1 
ATOM   2950 H  HB2  . TYR A 1 188 ? 25.10954  3.62827   -2.45189  1.000 31.01871  ? 180 TYR A HB2  1 
ATOM   2951 H  HB3  . TYR A 1 188 ? 24.69887  2.21945   -1.84198  1.000 31.01871  ? 180 TYR A HB3  1 
ATOM   2952 H  HD1  . TYR A 1 188 ? 23.75513  4.24063   -4.63322  1.000 28.68162  ? 180 TYR A HD1  1 
ATOM   2953 H  HD2  . TYR A 1 188 ? 24.33220  0.49544   -3.38088  1.000 32.63796  ? 180 TYR A HD2  1 
ATOM   2954 H  HE1  . TYR A 1 188 ? 23.30474  3.46767   -6.75525  1.000 31.06515  ? 180 TYR A HE1  1 
ATOM   2955 H  HE2  . TYR A 1 188 ? 23.87852  -0.29217  -5.50751  1.000 25.39629  ? 180 TYR A HE2  1 
ATOM   2956 H  HH   . TYR A 1 188 ? 23.29282  1.69769   -8.15168  1.000 29.73770  ? 180 TYR A HH   1 
ATOM   2957 N  N    . TYR A 1 189 ? 22.60869  2.49901   0.38459   1.000 19.61611  ? 181 TYR A N    1 
ATOM   2958 C  CA   . TYR A 1 189 ? 22.68079  2.13454   1.79267   1.000 17.34633  ? 181 TYR A CA   1 
ATOM   2959 C  C    . TYR A 1 189 ? 22.70156  0.61418   1.92325   1.000 22.49224  ? 181 TYR A C    1 
ATOM   2960 O  O    . TYR A 1 189 ? 22.03585  -0.09454  1.15963   1.000 19.08167  ? 181 TYR A O    1 
ATOM   2961 C  CB   . TYR A 1 189 ? 21.49787  2.70629   2.58122   1.000 14.93458  ? 181 TYR A CB   1 
ATOM   2962 C  CG   . TYR A 1 189 ? 21.36944  4.20839   2.51320   1.000 20.17649  ? 181 TYR A CG   1 
ATOM   2963 C  CD1  . TYR A 1 189 ? 21.93309  5.01837   3.48950   1.000 21.64712  ? 181 TYR A CD1  1 
ATOM   2964 C  CD2  . TYR A 1 189 ? 20.69350  4.82338   1.46314   1.000 23.79469  ? 181 TYR A CD2  1 
ATOM   2965 C  CE1  . TYR A 1 189 ? 21.82289  6.41061   3.42835   1.000 19.22943  ? 181 TYR A CE1  1 
ATOM   2966 C  CE2  . TYR A 1 189 ? 20.57233  6.20900   1.40204   1.000 19.83893  ? 181 TYR A CE2  1 
ATOM   2967 C  CZ   . TYR A 1 189 ? 21.14609  6.98948   2.39182   1.000 22.11434  ? 181 TYR A CZ   1 
ATOM   2968 O  OH   . TYR A 1 189 ? 21.02638  8.35342   2.33897   1.000 22.16829  ? 181 TYR A OH   1 
ATOM   2969 H  H    . TYR A 1 189 ? 22.03726  2.02974   -0.05455  1.000 23.51614  ? 181 TYR A H    1 
ATOM   2970 H  HA   . TYR A 1 189 ? 23.50084  2.48470   2.17452   1.000 20.79240  ? 181 TYR A HA   1 
ATOM   2971 H  HB2  . TYR A 1 189 ? 20.67832  2.32576   2.22847   1.000 17.89831  ? 181 TYR A HB2  1 
ATOM   2972 H  HB3  . TYR A 1 189 ? 21.60186  2.46295   3.51442   1.000 17.89831  ? 181 TYR A HB3  1 
ATOM   2973 H  HD1  . TYR A 1 189 ? 22.39254  4.62757   4.19738   1.000 25.95335  ? 181 TYR A HD1  1 
ATOM   2974 H  HD2  . TYR A 1 189 ? 20.31715  4.30075   0.79223   1.000 28.53044  ? 181 TYR A HD2  1 
ATOM   2975 H  HE1  . TYR A 1 189 ? 22.20788  6.93976   4.08916   1.000 23.05213  ? 181 TYR A HE1  1 
ATOM   2976 H  HE2  . TYR A 1 189 ? 20.10912  6.60787   0.70115   1.000 23.78353  ? 181 TYR A HE2  1 
ATOM   2977 H  HH   . TYR A 1 189 ? 20.56494  8.57574   1.67320   1.000 26.57876  ? 181 TYR A HH   1 
ATOM   2978 N  N    . ALA A 1 190 ? 23.47162  0.11633   2.89282   1.000 17.03707  ? 182 ALA A N    1 
ATOM   2979 C  CA   . ALA A 1 190 ? 23.53091  -1.30965  3.18706   1.000 18.14569  ? 182 ALA A CA   1 
ATOM   2980 C  C    . ALA A 1 190 ? 23.60949  -1.53636  4.69088   1.000 21.58022  ? 182 ALA A C    1 
ATOM   2981 O  O    . ALA A 1 190 ? 24.35964  -0.85757  5.39969   1.000 17.90375  ? 182 ALA A O    1 
ATOM   2982 C  CB   . ALA A 1 190 ? 24.72709  -1.97141  2.50841   1.000 20.76712  ? 182 ALA A CB   1 
ATOM   2983 H  H    . ALA A 1 190 ? 23.97532  0.59472   3.39979   1.000 20.42129  ? 182 ALA A H    1 
ATOM   2984 H  HA   . ALA A 1 190 ? 22.71718  -1.72789  2.86486   1.000 21.75164  ? 182 ALA A HA   1 
ATOM   2985 H  HB1  . ALA A 1 190 ? 24.73682  -2.91453  2.73500   1.000 24.89736  ? 182 ALA A HB1  1 
ATOM   2986 H  HB2  . ALA A 1 190 ? 24.64523  -1.86279  1.54800   1.000 24.89736  ? 182 ALA A HB2  1 
ATOM   2987 H  HB3  . ALA A 1 190 ? 25.54176  -1.54771  2.82097   1.000 24.89736  ? 182 ALA A HB3  1 
ATOM   2988 N  N    . LEU A 1 191 ? 22.83110  -2.50151  5.17652   1.000 16.34195  ? 183 LEU A N    1 
ATOM   2989 C  CA   . LEU A 1 191 ? 22.75045  -2.71288  6.61738   1.000 17.76131  ? 183 LEU A CA   1 
ATOM   2990 C  C    . LEU A 1 191 ? 24.07332  -3.22726  7.18545   1.000 20.40158  ? 183 LEU A C    1 
ATOM   2991 O  O    . LEU A 1 191 ? 24.59354  -2.67632  8.16272   1.000 23.45920  ? 183 LEU A O    1 
ATOM   2992 C  CB   . LEU A 1 191 ? 21.61119  -3.68007  6.93418   1.000 20.47580  ? 183 LEU A CB   1 
ATOM   2993 C  CG   . LEU A 1 191 ? 20.19744  -3.18530  6.65119   1.000 19.81833  ? 183 LEU A CG   1 
ATOM   2994 C  CD1  . LEU A 1 191 ? 19.17088  -4.28244  6.81488   1.000 20.56199  ? 183 LEU A CD1  1 
ATOM   2995 C  CD2  . LEU A 1 191 ? 19.86678  -1.98727  7.53401   1.000 23.92836  ? 183 LEU A CD2  1 
ATOM   2996 H  H    . LEU A 1 191 ? 22.35060  -3.03539  4.70356   1.000 19.58715  ? 183 LEU A H    1 
ATOM   2997 H  HA   . LEU A 1 191 ? 22.55865  -1.86419  7.04614   1.000 21.29038  ? 183 LEU A HA   1 
ATOM   2998 H  HB2  . LEU A 1 191 ? 21.74308  -4.48253  6.40545   1.000 24.54777  ? 183 LEU A HB2  1 
ATOM   2999 H  HB3  . LEU A 1 191 ? 21.65382  -3.89468  7.87918   1.000 24.54777  ? 183 LEU A HB3  1 
ATOM   3000 H  HG   . LEU A 1 191 ? 20.15424  -2.90156  5.72462   1.000 23.75881  ? 183 LEU A HG   1 
ATOM   3001 H  HD11 . LEU A 1 191 ? 18.29285  -3.92714  6.60578   1.000 24.65120  ? 183 LEU A HD11 1 
ATOM   3002 H  HD12 . LEU A 1 191 ? 19.38629  -5.00930  6.20976   1.000 24.65120  ? 183 LEU A HD12 1 
ATOM   3003 H  HD13 . LEU A 1 191 ? 19.19003  -4.59860  7.73171   1.000 24.65120  ? 183 LEU A HD13 1 
ATOM   3004 H  HD21 . LEU A 1 191 ? 18.96638  -1.68676  7.33430   1.000 28.69084  ? 183 LEU A HD21 1 
ATOM   3005 H  HD22 . LEU A 1 191 ? 19.92760  -2.25433  8.46454   1.000 28.69084  ? 183 LEU A HD22 1 
ATOM   3006 H  HD23 . LEU A 1 191 ? 20.50085  -1.27617  7.35184   1.000 28.69084  ? 183 LEU A HD23 1 
ATOM   3007 N  N    . ALA A 1 192 ? 24.63506  -4.27631  6.59189   1.000 19.16699  ? 184 ALA A N    1 
ATOM   3008 C  CA   . ALA A 1 192 ? 25.80901  -4.93024  7.15187   1.000 23.02218  ? 184 ALA A CA   1 
ATOM   3009 C  C    . ALA A 1 192 ? 26.76418  -5.37917  6.05047   1.000 29.99979  ? 184 ALA A C    1 
ATOM   3010 O  O    . ALA A 1 192 ? 26.33422  -5.69015  4.93359   1.000 20.21368  ? 184 ALA A O    1 
ATOM   3011 C  CB   . ALA A 1 192 ? 25.41918  -6.14598  8.00831   1.000 25.94586  ? 184 ALA A CB   1 
ATOM   3012 H  H    . ALA A 1 192 ? 24.35104  -4.62762  5.86010   1.000 22.97720  ? 184 ALA A H    1 
ATOM   3013 H  HA   . ALA A 1 192 ? 26.28492  -4.28795  7.70130   1.000 27.60343  ? 184 ALA A HA   1 
ATOM   3014 H  HB1  . ALA A 1 192 ? 26.22596  -6.57150  8.33837   1.000 31.11184  ? 184 ALA A HB1  1 
ATOM   3015 H  HB2  . ALA A 1 192 ? 24.87493  -5.84611  8.75313   1.000 31.11184  ? 184 ALA A HB2  1 
ATOM   3016 H  HB3  . ALA A 1 192 ? 24.91643  -6.76952  7.46120   1.000 31.11184  ? 184 ALA A HB3  1 
ATOM   3017 N  N    . PRO A 1 193 ? 28.06199  -5.39810  6.33970   1.000 32.00341  ? 185 PRO A N    1 
ATOM   3018 C  CA   . PRO A 1 193 ? 29.00803  -6.00852  5.39437   1.000 25.94060  ? 185 PRO A CA   1 
ATOM   3019 C  C    . PRO A 1 193 ? 28.86176  -7.52355  5.38164   1.000 29.14701  ? 185 PRO A C    1 
ATOM   3020 O  O    . PRO A 1 193 ? 28.39896  -8.13066  6.35029   1.000 23.13193  ? 185 PRO A O    1 
ATOM   3021 C  CB   . PRO A 1 193 ? 30.38662  -5.59092  5.92154   1.000 35.21777  ? 185 PRO A CB   1 
ATOM   3022 C  CG   . PRO A 1 193 ? 30.12913  -4.61475  7.06018   1.000 37.20682  ? 185 PRO A CG   1 
ATOM   3023 C  CD   . PRO A 1 193 ? 28.72529  -4.86336  7.54227   1.000 31.58407  ? 185 PRO A CD   1 
ATOM   3024 H  HA   . PRO A 1 193 ? 28.88611  -5.64936  4.50160   1.000 31.10552  ? 185 PRO A HA   1 
ATOM   3025 H  HB2  . PRO A 1 193 ? 30.86272  -6.37299  6.24184   1.000 42.23813  ? 185 PRO A HB2  1 
ATOM   3026 H  HB3  . PRO A 1 193 ? 30.89045  -5.16360  5.21129   1.000 42.23813  ? 185 PRO A HB3  1 
ATOM   3027 H  HG2  . PRO A 1 193 ? 30.76651  -4.77562  7.77345   1.000 44.62499  ? 185 PRO A HG2  1 
ATOM   3028 H  HG3  . PRO A 1 193 ? 30.21979  -3.70613  6.73293   1.000 44.62499  ? 185 PRO A HG3  1 
ATOM   3029 H  HD2  . PRO A 1 193 ? 28.71486  -5.51252  8.26295   1.000 37.87769  ? 185 PRO A HD2  1 
ATOM   3030 H  HD3  . PRO A 1 193 ? 28.30610  -4.03829  7.83287   1.000 37.87769  ? 185 PRO A HD3  1 
ATOM   3031 N  N    . PHE A 1 194 ? 29.28122  -8.13068  4.26219   1.000 29.87091  ? 186 PHE A N    1 
ATOM   3032 C  CA   . PHE A 1 194 ? 29.14312  -9.56037  4.05142   1.000 25.10503  ? 186 PHE A CA   1 
ATOM   3033 C  C    . PHE A 1 194 ? 30.38679  -10.09595 3.38040   1.000 23.14289  ? 186 PHE A C    1 
ATOM   3034 O  O    . PHE A 1 194 ? 30.92011  -9.45768  2.46811   1.000 29.01381  ? 186 PHE A O    1 
ATOM   3035 C  CB   . PHE A 1 194 ? 27.91044  -9.85679  3.17841   1.000 27.10091  ? 186 PHE A CB   1 
ATOM   3036 C  CG   . PHE A 1 194 ? 27.63990  -11.30479 2.94729   1.000 34.32796  ? 186 PHE A CG   1 
ATOM   3037 C  CD1  . PHE A 1 194 ? 27.36811  -12.14611 4.00902   1.000 34.12720  ? 186 PHE A CD1  1 
ATOM   3038 C  CD2  . PHE A 1 194 ? 27.67436  -11.83794 1.66685   1.000 42.39844  ? 186 PHE A CD2  1 
ATOM   3039 C  CE1  . PHE A 1 194 ? 27.12107  -13.49132 3.80732   1.000 29.71945  ? 186 PHE A CE1  1 
ATOM   3040 C  CE2  . PHE A 1 194 ? 27.45102  -13.20615 1.46976   1.000 36.39986  ? 186 PHE A CE2  1 
ATOM   3041 C  CZ   . PHE A 1 194 ? 27.14837  -14.01385 2.54403   1.000 28.52817  ? 186 PHE A CZ   1 
ATOM   3042 H  H    . PHE A 1 194 ? 29.65411  -7.72042  3.60474   1.000 35.82190  ? 186 PHE A H    1 
ATOM   3043 H  HA   . PHE A 1 194 ? 29.04641  -10.01421 4.90323   1.000 30.10285  ? 186 PHE A HA   1 
ATOM   3044 H  HB2  . PHE A 1 194 ? 27.12874  -9.47984  3.61173   1.000 32.49791  ? 186 PHE A HB2  1 
ATOM   3045 H  HB3  . PHE A 1 194 ? 28.04098  -9.44268  2.31102   1.000 32.49791  ? 186 PHE A HB3  1 
ATOM   3046 H  HD1  . PHE A 1 194 ? 27.35109  -11.80211 4.87289   1.000 40.92945  ? 186 PHE A HD1  1 
ATOM   3047 H  HD2  . PHE A 1 194 ? 27.84604  -11.28581 0.93844   1.000 50.85494  ? 186 PHE A HD2  1 
ATOM   3048 H  HE1  . PHE A 1 194 ? 26.93576  -14.04253 4.53307   1.000 35.64015  ? 186 PHE A HE1  1 
ATOM   3049 H  HE2  . PHE A 1 194 ? 27.50689  -13.56896 0.61527   1.000 43.65665  ? 186 PHE A HE2  1 
ATOM   3050 H  HZ   . PHE A 1 194 ? 26.96250  -14.91516 2.40989   1.000 34.21062  ? 186 PHE A HZ   1 
ATOM   3051 N  N    . SER A 1 195 ? 30.78213  -11.31061 3.78832   1.000 28.84802  ? 187 SER A N    1 
ATOM   3052 C  CA   . SER A 1 195 ? 31.86663  -12.03689 3.14677   1.000 36.51426  ? 187 SER A CA   1 
ATOM   3053 C  C    . SER A 1 195 ? 31.57754  -13.52780 3.23859   1.000 30.87097  ? 187 SER A C    1 
ATOM   3054 O  O    . SER A 1 195 ? 31.11622  -14.01484 4.27306   1.000 39.44343  ? 187 SER A O    1 
ATOM   3055 C  CB   . SER A 1 195 ? 33.23999  -11.73204 3.77608   1.000 25.63740  ? 187 SER A CB   1 
ATOM   3056 O  OG   . SER A 1 195 ? 33.44376  -12.52067 4.92793   1.000 44.31134  ? 187 SER A OG   1 
ATOM   3057 H  H    . SER A 1 195 ? 30.42636  -11.73486 4.44638   1.000 34.59443  ? 187 SER A H    1 
ATOM   3058 H  HA   . SER A 1 195 ? 31.91325  -11.77720 2.21334   1.000 43.79392  ? 187 SER A HA   1 
ATOM   3059 H  HB2  . SER A 1 195 ? 33.93561  -11.92977 3.12962   1.000 30.74169  ? 187 SER A HB2  1 
ATOM   3060 H  HB3  . SER A 1 195 ? 33.27396  -10.79480 4.02375   1.000 30.74169  ? 187 SER A HB3  1 
ATOM   3061 H  HG   . SER A 1 195 ? 34.21787  -12.39502 5.22888   1.000 53.15042  ? 187 SER A HG   1 
ATOM   3062 N  N    . THR A 1 196 ? 31.82733  -14.25099 2.14545   1.000 24.87958  ? 188 THR A N    1 
ATOM   3063 C  CA   . THR A 1 196 ? 31.61835  -15.69499 2.13519   1.000 32.95292  ? 188 THR A CA   1 
ATOM   3064 C  C    . THR A 1 196 ? 32.74181  -16.37077 1.35809   1.000 28.54483  ? 188 THR A C    1 
ATOM   3065 O  O    . THR A 1 196 ? 33.56717  -15.71453 0.71932   1.000 27.25540  ? 188 THR A O    1 
ATOM   3066 C  CB   . THR A 1 196 ? 30.24823  -16.06920 1.54477   1.000 28.95926  ? 188 THR A CB   1 
ATOM   3067 O  OG1  . THR A 1 196 ? 30.02276  -17.47922 1.69456   1.000 43.06914  ? 188 THR A OG1  1 
ATOM   3068 C  CG2  . THR A 1 196 ? 30.17479  -15.69680 0.09121   1.000 28.04599  ? 188 THR A CG2  1 
ATOM   3069 H  H    . THR A 1 196 ? 32.11677  -13.92754 1.40302   1.000 29.83231  ? 188 THR A H    1 
ATOM   3070 H  HA   . THR A 1 196 ? 31.65330  -16.01910 3.04877   1.000 39.52031  ? 188 THR A HA   1 
ATOM   3071 H  HB   . THR A 1 196 ? 29.55290  -15.58344 2.01537   1.000 34.72793  ? 188 THR A HB   1 
ATOM   3072 H  HG1  . THR A 1 196 ? 29.22869  -17.66608 1.49420   1.000 51.65978  ? 188 THR A HG1  1 
ATOM   3073 H  HG21 . THR A 1 196 ? 29.29649  -15.90890 -0.26165  1.000 33.63200  ? 188 THR A HG21 1 
ATOM   3074 H  HG22 . THR A 1 196 ? 30.33614  -14.74637 -0.01633  1.000 33.63200  ? 188 THR A HG22 1 
ATOM   3075 H  HG23 . THR A 1 196 ? 30.84309  -16.18840 -0.41139  1.000 33.63200  ? 188 THR A HG23 1 
ATOM   3076 N  N    . TYR A 1 197 ? 32.75746  -17.70902 1.41359   1.000 24.55190  ? 189 TYR A N    1 
ATOM   3077 C  CA   . TYR A 1 197 ? 33.80240  -18.52712 0.80369   1.000 25.02480  ? 189 TYR A CA   1 
ATOM   3078 C  C    . TYR A 1 197 ? 33.20574  -19.60185 -0.10627  1.000 28.01765  ? 189 TYR A C    1 
ATOM   3079 O  O    . TYR A 1 197 ? 33.78141  -20.68460 -0.26196  1.000 25.55251  ? 189 TYR A O    1 
ATOM   3080 C  CB   . TYR A 1 197 ? 34.68780  -19.16259 1.87777   1.000 25.09743  ? 189 TYR A CB   1 
ATOM   3081 C  CG   . TYR A 1 197 ? 33.91911  -19.84338 2.98639   1.000 22.15007  ? 189 TYR A CG   1 
ATOM   3082 C  CD1  . TYR A 1 197 ? 33.42686  -19.11781 4.06847   1.000 36.81788  ? 189 TYR A CD1  1 
ATOM   3083 C  CD2  . TYR A 1 197 ? 33.67204  -21.20945 2.94737   1.000 31.05028  ? 189 TYR A CD2  1 
ATOM   3084 C  CE1  . TYR A 1 197 ? 32.71483  -19.73629 5.08256   1.000 30.10511  ? 189 TYR A CE1  1 
ATOM   3085 C  CE2  . TYR A 1 197 ? 32.95727  -21.84261 3.96769   1.000 28.51324  ? 189 TYR A CE2  1 
ATOM   3086 C  CZ   . TYR A 1 197 ? 32.48966  -21.09968 5.02971   1.000 37.59118  ? 189 TYR A CZ   1 
ATOM   3087 O  OH   . TYR A 1 197 ? 31.78602  -21.72477 6.03659   1.000 45.30604  ? 189 TYR A OH   1 
ATOM   3088 H  H    . TYR A 1 197 ? 32.15416  -18.17520 1.81147   1.000 29.43909  ? 189 TYR A H    1 
ATOM   3089 H  HA   . TYR A 1 197 ? 34.36036  -17.95597 0.25290   1.000 30.00656  ? 189 TYR A HA   1 
ATOM   3090 H  HB2  . TYR A 1 197 ? 35.25401  -19.82961 1.45896   1.000 30.09373  ? 189 TYR A HB2  1 
ATOM   3091 H  HB3  . TYR A 1 197 ? 35.23390  -18.46934 2.28034   1.000 30.09373  ? 189 TYR A HB3  1 
ATOM   3092 H  HD1  . TYR A 1 197 ? 33.57908  -18.20133 4.11081   1.000 44.15827  ? 189 TYR A HD1  1 
ATOM   3093 H  HD2  . TYR A 1 197 ? 33.98741  -21.71105 2.23054   1.000 37.23715  ? 189 TYR A HD2  1 
ATOM   3094 H  HE1  . TYR A 1 197 ? 32.38939  -19.23670 5.79628   1.000 36.10294  ? 189 TYR A HE1  1 
ATOM   3095 H  HE2  . TYR A 1 197 ? 32.79846  -22.75818 3.93019   1.000 34.19270  ? 189 TYR A HE2  1 
ATOM   3096 H  HH   . TYR A 1 197 ? 31.79909  -22.55687 5.92242   1.000 54.34406  ? 189 TYR A HH   1 
ATOM   3097 N  N    . VAL A 1 198 ? 32.05579  -19.31681 -0.70871  1.000 32.49040  ? 190 VAL A N    1 
ATOM   3098 C  CA   . VAL A 1 198 ? 31.42324  -20.19862 -1.68832  1.000 25.86486  ? 190 VAL A CA   1 
ATOM   3099 C  C    . VAL A 1 198 ? 30.91511  -19.39048 -2.85123  1.000 34.83329  ? 190 VAL A C    1 
ATOM   3100 O  O    . VAL A 1 198 ? 30.73400  -18.14462 -2.75579  1.000 21.82450  ? 190 VAL A O    1 
ATOM   3101 C  CB   . VAL A 1 198 ? 30.26764  -21.00853 -1.06285  1.000 22.90658  ? 190 VAL A CB   1 
ATOM   3102 C  CG1  . VAL A 1 198 ? 30.79314  -21.90701 0.06867   1.000 32.35884  ? 190 VAL A CG1  1 
ATOM   3103 C  CG2  . VAL A 1 198 ? 29.17925  -20.07059 -0.56819  1.000 24.53214  ? 190 VAL A CG2  1 
ATOM   3104 H  H    . VAL A 1 198 ? 31.60768  -18.59725 -0.56370  1.000 38.96529  ? 190 VAL A H    1 
ATOM   3105 H  HA   . VAL A 1 198 ? 32.08768  -20.81724 -2.02997  1.000 31.01464  ? 190 VAL A HA   1 
ATOM   3106 H  HB   . VAL A 1 198 ? 29.87671  -21.58684 -1.73637  1.000 27.46471  ? 190 VAL A HB   1 
ATOM   3107 H  HG11 . VAL A 1 198 ? 30.05238  -22.40879 0.44336   1.000 38.80742  ? 190 VAL A HG11 1 
ATOM   3108 H  HG12 . VAL A 1 198 ? 31.45563  -22.51600 -0.29347  1.000 38.80742  ? 190 VAL A HG12 1 
ATOM   3109 H  HG13 . VAL A 1 198 ? 31.19525  -21.34990 0.75339   1.000 38.80742  ? 190 VAL A HG13 1 
ATOM   3110 H  HG21 . VAL A 1 198 ? 28.47860  -20.59356 -0.14808  1.000 29.41538  ? 190 VAL A HG21 1 
ATOM   3111 H  HG22 . VAL A 1 198 ? 29.56229  -19.45364 0.07490   1.000 29.41538  ? 190 VAL A HG22 1 
ATOM   3112 H  HG23 . VAL A 1 198 ? 28.81827  -19.57978 -1.32297  1.000 29.41538  ? 190 VAL A HG23 1 
ATOM   3113 N  N    . PRO A 1 199 ? 30.64686  -20.02641 -4.00030  1.000 36.35320  ? 191 PRO A N    1 
ATOM   3114 C  CA   . PRO A 1 199 ? 30.03880  -19.34877 -5.14519  1.000 35.71742  ? 191 PRO A CA   1 
ATOM   3115 C  C    . PRO A 1 199 ? 28.52619  -19.54900 -5.20298  1.000 34.98388  ? 191 PRO A C    1 
ATOM   3116 O  O    . PRO A 1 199 ? 27.78452  -18.62939 -4.88393  1.000 40.68481  ? 191 PRO A O    1 
ATOM   3117 C  CB   . PRO A 1 199 ? 30.72831  -20.00807 -6.33835  1.000 26.53098  ? 191 PRO A CB   1 
ATOM   3118 C  CG   . PRO A 1 199 ? 30.99133  -21.43137 -5.86492  1.000 23.71211  ? 191 PRO A CG   1 
ATOM   3119 C  CD   . PRO A 1 199 ? 31.04318  -21.41360 -4.33347  1.000 29.72635  ? 191 PRO A CD   1 
ATOM   3120 H  HA   . PRO A 1 199 ? 30.23661  -18.39916 -5.14062  1.000 42.83771  ? 191 PRO A HA   1 
ATOM   3121 H  HB2  . PRO A 1 199 ? 30.14271  -19.99740 -7.11156  1.000 31.81399  ? 191 PRO A HB2  1 
ATOM   3122 H  HB3  . PRO A 1 199 ? 31.55678  -19.54704 -6.54324  1.000 31.81399  ? 191 PRO A HB3  1 
ATOM   3123 H  HG2  . PRO A 1 199 ? 30.27305  -22.00722 -6.17048  1.000 28.43134  ? 191 PRO A HG2  1 
ATOM   3124 H  HG3  . PRO A 1 199 ? 31.83800  -21.73669 -6.22660  1.000 28.43134  ? 191 PRO A HG3  1 
ATOM   3125 H  HD2  . PRO A 1 199 ? 30.41636  -22.05198 -3.95866  1.000 35.64843  ? 191 PRO A HD2  1 
ATOM   3126 H  HD3  . PRO A 1 199 ? 31.93975  -21.60311 -4.01545  1.000 35.64843  ? 191 PRO A HD3  1 
ATOM   3127 N  N    . LEU A 1 214 ? 14.57116  -18.47073 3.97840   1.000 40.59729  ? 206 LEU A N    1 
ATOM   3128 C  CA   . LEU A 1 214 ? 15.73850  -17.65153 4.29882   1.000 46.15532  ? 206 LEU A CA   1 
ATOM   3129 C  C    . LEU A 1 214 ? 16.79606  -18.47037 5.03565   1.000 40.88672  ? 206 LEU A C    1 
ATOM   3130 O  O    . LEU A 1 214 ? 16.48401  -19.19758 5.97405   1.000 45.14781  ? 206 LEU A O    1 
ATOM   3131 C  CB   . LEU A 1 214 ? 15.33940  -16.44349 5.15433   1.000 39.30032  ? 206 LEU A CB   1 
ATOM   3132 C  CG   . LEU A 1 214 ? 15.34340  -15.08033 4.45682   1.000 40.93345  ? 206 LEU A CG   1 
ATOM   3133 C  CD1  . LEU A 1 214 ? 14.43799  -15.09824 3.23662   1.000 40.36963  ? 206 LEU A CD1  1 
ATOM   3134 C  CD2  . LEU A 1 214 ? 14.94058  -13.96877 5.44126   1.000 31.76860  ? 206 LEU A CD2  1 
ATOM   3135 H  HA   . LEU A 1 214 ? 16.12230  -17.32361 3.47053   1.000 55.36319  ? 206 LEU A HA   1 
ATOM   3136 H  HB2  . LEU A 1 214 ? 14.43911  -16.59265 5.48316   1.000 47.13720  ? 206 LEU A HB2  1 
ATOM   3137 H  HB3  . LEU A 1 214 ? 15.95888  -16.38463 5.89842   1.000 47.13720  ? 206 LEU A HB3  1 
ATOM   3138 H  HG   . LEU A 1 214 ? 16.24122  -14.88354 4.14686   1.000 49.09696  ? 206 LEU A HG   1 
ATOM   3139 H  HD11 . LEU A 1 214 ? 14.39242  -14.20381 2.86404   1.000 48.42037  ? 206 LEU A HD11 1 
ATOM   3140 H  HD12 . LEU A 1 214 ? 14.80434  -15.71161 2.58052   1.000 48.42037  ? 206 LEU A HD12 1 
ATOM   3141 H  HD13 . LEU A 1 214 ? 13.55271  -15.39047 3.50453   1.000 48.42037  ? 206 LEU A HD13 1 
ATOM   3142 H  HD21 . LEU A 1 214 ? 14.88075  -13.12808 4.96108   1.000 38.09913  ? 206 LEU A HD21 1 
ATOM   3143 H  HD22 . LEU A 1 214 ? 14.08015  -14.18889 5.83127   1.000 38.09913  ? 206 LEU A HD22 1 
ATOM   3144 H  HD23 . LEU A 1 214 ? 15.61277  -13.90482 6.13765   1.000 38.09913  ? 206 LEU A HD23 1 
ATOM   3145 N  N    . SER A 1 215 ? 18.05202  -18.33899 4.61218   1.000 48.64891  ? 207 SER A N    1 
ATOM   3146 C  CA   . SER A 1 215 ? 19.15448  -19.06513 5.22953   1.000 61.92313  ? 207 SER A CA   1 
ATOM   3147 C  C    . SER A 1 215 ? 20.01431  -18.18963 6.12906   1.000 56.37218  ? 207 SER A C    1 
ATOM   3148 O  O    . SER A 1 215 ? 20.63351  -18.70708 7.06542   1.000 50.42713  ? 207 SER A O    1 
ATOM   3149 C  CB   . SER A 1 215 ? 20.03626  -19.70615 4.14881   1.000 44.77298  ? 207 SER A CB   1 
ATOM   3150 O  OG   . SER A 1 215 ? 19.24399  -20.23947 3.10370   1.000 48.73463  ? 207 SER A OG   1 
ATOM   3151 H  H    . SER A 1 215 ? 18.29151  -17.82951 3.96205   1.000 58.35550  ? 207 SER A H    1 
ATOM   3152 H  HA   . SER A 1 215 ? 18.79398  -19.78136 5.77538   1.000 74.28457  ? 207 SER A HA   1 
ATOM   3153 H  HB2  . SER A 1 215 ? 20.62861  -19.03076 3.78293   1.000 53.70439  ? 207 SER A HB2  1 
ATOM   3154 H  HB3  . SER A 1 215 ? 20.55541  -20.42161 4.54818   1.000 53.70439  ? 207 SER A HB3  1 
ATOM   3155 H  HG   . SER A 1 215 ? 19.73297  -20.62873 2.54247   1.000 58.45837  ? 207 SER A HG   1 
ATOM   3156 N  N    . VAL A 1 216 ? 20.09432  -16.88845 5.86244   1.000 45.36367  ? 208 VAL A N    1 
ATOM   3157 C  CA   . VAL A 1 216 ? 20.71983  -15.93958 6.77648   1.000 42.13066  ? 208 VAL A CA   1 
ATOM   3158 C  C    . VAL A 1 216 ? 19.61662  -15.17411 7.49253   1.000 42.91625  ? 208 VAL A C    1 
ATOM   3159 O  O    . VAL A 1 216 ? 18.85962  -14.42377 6.86443   1.000 37.48480  ? 208 VAL A O    1 
ATOM   3160 C  CB   . VAL A 1 216 ? 21.66579  -14.97849 6.04195   1.000 34.99087  ? 208 VAL A CB   1 
ATOM   3161 C  CG1  . VAL A 1 216 ? 22.36973  -14.08281 7.03709   1.000 37.83335  ? 208 VAL A CG1  1 
ATOM   3162 C  CG2  . VAL A 1 216 ? 22.66154  -15.74979 5.21103   1.000 50.34359  ? 208 VAL A CG2  1 
ATOM   3163 H  H    . VAL A 1 216 ? 19.78761  -16.52627 5.14525   1.000 54.41321  ? 208 VAL A H    1 
ATOM   3164 H  HA   . VAL A 1 216 ? 21.23644  -16.42966 7.43515   1.000 50.53360  ? 208 VAL A HA   1 
ATOM   3165 H  HB   . VAL A 1 216 ? 21.15035  -14.41803 5.44104   1.000 41.96585  ? 208 VAL A HB   1 
ATOM   3166 H  HG11 . VAL A 1 216 ? 22.98585  -13.50451 6.56078   1.000 45.37683  ? 208 VAL A HG11 1 
ATOM   3167 H  HG12 . VAL A 1 216 ? 21.70839  -13.54848 7.50401   1.000 45.37683  ? 208 VAL A HG12 1 
ATOM   3168 H  HG13 . VAL A 1 216 ? 22.85585  -14.63446 7.66976   1.000 45.37683  ? 208 VAL A HG13 1 
ATOM   3169 H  HG21 . VAL A 1 216 ? 23.29630  -15.12836 4.82139   1.000 60.38912  ? 208 VAL A HG21 1 
ATOM   3170 H  HG22 . VAL A 1 216 ? 23.12560  -16.38267 5.78112   1.000 60.38912  ? 208 VAL A HG22 1 
ATOM   3171 H  HG23 . VAL A 1 216 ? 22.18793  -16.22259 4.50886   1.000 60.38912  ? 208 VAL A HG23 1 
ATOM   3172 N  N    . GLY A 1 217 ? 19.51478  -15.37097 8.80336   1.000 29.89319  ? 209 GLY A N    1 
ATOM   3173 C  CA   . GLY A 1 217 ? 18.56787  -14.60474 9.58936   1.000 35.93858  ? 209 GLY A CA   1 
ATOM   3174 C  C    . GLY A 1 217 ? 17.14382  -15.10858 9.43421   1.000 35.08007  ? 209 GLY A C    1 
ATOM   3175 O  O    . GLY A 1 217 ? 16.89712  -16.30186 9.27626   1.000 43.21124  ? 209 GLY A O    1 
ATOM   3176 H  H    . GLY A 1 217 ? 19.97953  -15.93744 9.25361   1.000 35.84864  ? 209 GLY A H    1 
ATOM   3177 H  HA2  . GLY A 1 217 ? 18.81063  -14.65933 10.52691  1.000 43.10310  ? 209 GLY A HA2  1 
ATOM   3178 H  HA3  . GLY A 1 217 ? 18.59550  -13.67639 9.30953   1.000 43.10310  ? 209 GLY A HA3  1 
ATOM   3179 N  N    . SER A 1 218 ? 16.19746  -14.17449 9.48797   1.000 26.29584  ? 210 SER A N    1 
ATOM   3180 C  CA   . SER A 1 218 ? 14.78143  -14.50499 9.46005   1.000 26.50611  ? 210 SER A CA   1 
ATOM   3181 C  C    . SER A 1 218 ? 14.00523  -13.28311 8.98372   1.000 28.31102  ? 210 SER A C    1 
ATOM   3182 O  O    . SER A 1 218 ? 14.52053  -12.15524 9.02930   1.000 20.28546  ? 210 SER A O    1 
ATOM   3183 C  CB   . SER A 1 218 ? 14.29185  -14.94959 10.84512  1.000 27.14476  ? 210 SER A CB   1 
ATOM   3184 O  OG   . SER A 1 218 ? 14.12371  -13.83250 11.69941  1.000 31.14983  ? 210 SER A OG   1 
ATOM   3185 H  H    . SER A 1 218 ? 16.35578  -13.33090 9.54168   1.000 31.53182  ? 210 SER A H    1 
ATOM   3186 H  HA   . SER A 1 218 ? 14.62734  -15.22598 8.82971   1.000 31.78415  ? 210 SER A HA   1 
ATOM   3187 H  HB2  . SER A 1 218 ? 13.44079  -15.40488 10.74863  1.000 32.55052  ? 210 SER A HB2  1 
ATOM   3188 H  HB3  . SER A 1 218 ? 14.94690  -15.54975 11.23449  1.000 32.55052  ? 210 SER A HB3  1 
ATOM   3189 H  HG   . SER A 1 218 ? 13.31274  -13.74315 11.89926  1.000 37.35661  ? 210 SER A HG   1 
ATOM   3190 N  N    . PRO A 1 219 ? 12.77172  -13.47580 8.50216   1.000 22.46577  ? 211 PRO A N    1 
ATOM   3191 C  CA   . PRO A 1 219 ? 11.97090  -12.31112 8.07533   1.000 26.82899  ? 211 PRO A CA   1 
ATOM   3192 C  C    . PRO A 1 219 ? 11.86394  -11.24237 9.14649   1.000 32.58383  ? 211 PRO A C    1 
ATOM   3193 O  O    . PRO A 1 219 ? 12.14959  -10.06955 8.86997   1.000 24.22261  ? 211 PRO A O    1 
ATOM   3194 C  CB   . PRO A 1 219 ? 10.60254  -12.91869 7.74023   1.000 31.89897  ? 211 PRO A CB   1 
ATOM   3195 C  CG   . PRO A 1 219 ? 10.91157  -14.35960 7.36828   1.000 32.78045  ? 211 PRO A CG   1 
ATOM   3196 C  CD   . PRO A 1 219 ? 12.12615  -14.76419 8.18366   1.000 36.57133  ? 211 PRO A CD   1 
ATOM   3197 H  HA   . PRO A 1 219 ? 12.35618  -11.93554 7.26824   1.000 32.17160  ? 211 PRO A HA   1 
ATOM   3198 H  HB2  . PRO A 1 219 ? 10.02019  -12.87479 8.51473   1.000 38.25557  ? 211 PRO A HB2  1 
ATOM   3199 H  HB3  . PRO A 1 219 ? 10.20086  -12.44395 6.99580   1.000 38.25557  ? 211 PRO A HB3  1 
ATOM   3200 H  HG2  . PRO A 1 219 ? 10.15150  -14.92130 7.58667   1.000 39.31335  ? 211 PRO A HG2  1 
ATOM   3201 H  HG3  . PRO A 1 219 ? 11.10371  -14.41570 6.41915   1.000 39.31335  ? 211 PRO A HG3  1 
ATOM   3202 H  HD2  . PRO A 1 219 ? 11.85894  -15.22527 8.99416   1.000 43.86241  ? 211 PRO A HD2  1 
ATOM   3203 H  HD3  . PRO A 1 219 ? 12.71936  -15.32708 7.66197   1.000 43.86241  ? 211 PRO A HD3  1 
ATOM   3204 N  N    . ASP A 1 220 ? 11.46585  -11.61731 10.37152  1.000 24.59742  ? 212 ASP A N    1 
ATOM   3205 C  CA   . ASP A 1 220 ? 11.28943  -10.62167 11.42717  1.000 28.54118  ? 212 ASP A CA   1 
ATOM   3206 C  C    . ASP A 1 220 ? 12.60031  -9.91291  11.75442  1.000 21.90312  ? 212 ASP A C    1 
ATOM   3207 O  O    . ASP A 1 220 ? 12.59768  -8.71562  12.06886  1.000 21.86175  ? 212 ASP A O    1 
ATOM   3208 C  CB   . ASP A 1 220 ? 10.69713  -11.27225 12.68280  1.000 21.46879  ? 212 ASP A CB   1 
ATOM   3209 C  CG   . ASP A 1 220 ? 11.48250  -12.47984 13.14057  1.000 40.19572  ? 212 ASP A CG   1 
ATOM   3210 O  OD1  . ASP A 1 220 ? 11.61910  -13.43093 12.34180  1.000 43.40957  ? 212 ASP A OD1  1 
ATOM   3211 O  OD2  . ASP A 1 220 ? 11.97308  -12.48245 14.29309  1.000 48.19544  ? 212 ASP A OD2  1 
ATOM   3212 H  H    . ASP A 1 220 ? 11.29573  -12.42625 10.60874  1.000 29.49371  ? 212 ASP A H    1 
ATOM   3213 H  HA   . ASP A 1 220 ? 10.65794  -9.95252  11.11997  1.000 34.22623  ? 212 ASP A HA   1 
ATOM   3214 H  HB2  . ASP A 1 220 ? 10.69596  -10.62392 13.40430  1.000 25.73935  ? 212 ASP A HB2  1 
ATOM   3215 H  HB3  . ASP A 1 220 ? 9.79009   -11.55866 12.49266  1.000 25.73935  ? 212 ASP A HB3  1 
ATOM   3216 N  N    . PHE A 1 221 ? 13.72841  -10.62186 11.68037  1.000 19.56025  ? 213 PHE A N    1 
ATOM   3217 C  CA   . PHE A 1 221 ? 15.01588  -9.97201  11.90994  1.000 18.73351  ? 213 PHE A CA   1 
ATOM   3218 C  C    . PHE A 1 221 ? 15.27645  -8.88633  10.86576  1.000 14.72652  ? 213 PHE A C    1 
ATOM   3219 O  O    . PHE A 1 221 ? 15.72023  -7.77754  11.19463  1.000 14.99836  ? 213 PHE A O    1 
ATOM   3220 C  CB   . PHE A 1 221 ? 16.14996  -11.01025 11.90011  1.000 20.18360  ? 213 PHE A CB   1 
ATOM   3221 C  CG   . PHE A 1 221 ? 17.52698  -10.39263 11.96706  1.000 16.40874  ? 213 PHE A CG   1 
ATOM   3222 C  CD1  . PHE A 1 221 ? 18.04739  -9.95312  13.17680  1.000 27.41712  ? 213 PHE A CD1  1 
ATOM   3223 C  CD2  . PHE A 1 221 ? 18.28475  -10.21649 10.82575  1.000 15.80362  ? 213 PHE A CD2  1 
ATOM   3224 C  CE1  . PHE A 1 221 ? 19.31545  -9.36643  13.25011  1.000 18.77402  ? 213 PHE A CE1  1 
ATOM   3225 C  CE2  . PHE A 1 221 ? 19.53945  -9.61943  10.89334  1.000 19.62205  ? 213 PHE A CE2  1 
ATOM   3226 C  CZ   . PHE A 1 221 ? 20.05144  -9.19099  12.10936  1.000 14.42640  ? 213 PHE A CZ   1 
ATOM   3227 H  H    . PHE A 1 221 ? 13.77367  -11.46207 11.50263  1.000 23.44911  ? 213 PHE A H    1 
ATOM   3228 H  HA   . PHE A 1 221 ? 14.99867  -9.55636  12.78621  1.000 22.45702  ? 213 PHE A HA   1 
ATOM   3229 H  HB2  . PHE A 1 221 ? 16.04754  -11.59375 12.66819  1.000 24.19713  ? 213 PHE A HB2  1 
ATOM   3230 H  HB3  . PHE A 1 221 ? 16.09480  -11.52709 11.08113  1.000 24.19713  ? 213 PHE A HB3  1 
ATOM   3231 H  HD1  . PHE A 1 221 ? 17.54391  -10.05047 13.95263  1.000 32.87736  ? 213 PHE A HD1  1 
ATOM   3232 H  HD2  . PHE A 1 221 ? 17.95305  -10.49970 10.00437  1.000 18.94116  ? 213 PHE A HD2  1 
ATOM   3233 H  HE1  . PHE A 1 221 ? 19.65741  -9.09637  14.07171  1.000 22.50564  ? 213 PHE A HE1  1 
ATOM   3234 H  HE2  . PHE A 1 221 ? 20.03901  -9.50662  10.11706  1.000 23.52327  ? 213 PHE A HE2  1 
ATOM   3235 H  HZ   . PHE A 1 221 ? 20.88844  -8.78758  12.14926  1.000 17.28850  ? 213 PHE A HZ   1 
ATOM   3236 N  N    . TRP A 1 222 ? 15.03772  -9.20158  9.58895   1.000 15.51720  ? 214 TRP A N    1 
ATOM   3237 C  CA   . TRP A 1 222 ? 15.42978  -8.28816  8.52083   1.000 16.78353  ? 214 TRP A CA   1 
ATOM   3238 C  C    . TRP A 1 222 ? 14.45257  -7.12776  8.38598   1.000 16.60184  ? 214 TRP A C    1 
ATOM   3239 O  O    . TRP A 1 222 ? 14.86984  -5.99362  8.12973   1.000 17.48542  ? 214 TRP A O    1 
ATOM   3240 C  CB   . TRP A 1 222 ? 15.55317  -9.04237  7.19972   1.000 14.32401  ? 214 TRP A CB   1 
ATOM   3241 C  CG   . TRP A 1 222 ? 16.81597  -9.85284  7.11151   1.000 15.40198  ? 214 TRP A CG   1 
ATOM   3242 C  CD1  . TRP A 1 222 ? 16.91790  -11.22298 7.02768   1.000 23.22227  ? 214 TRP A CD1  1 
ATOM   3243 C  CD2  . TRP A 1 222 ? 18.15611  -9.35532  7.12474   1.000 16.97623  ? 214 TRP A CD2  1 
ATOM   3244 N  NE1  . TRP A 1 222 ? 18.23833  -11.59869 6.96327   1.000 20.82193  ? 214 TRP A NE1  1 
ATOM   3245 C  CE2  . TRP A 1 222 ? 19.01909  -10.47271 7.03182   1.000 23.39142  ? 214 TRP A CE2  1 
ATOM   3246 C  CE3  . TRP A 1 222 ? 18.71379  -8.07376  7.20206   1.000 16.56660  ? 214 TRP A CE3  1 
ATOM   3247 C  CZ2  . TRP A 1 222 ? 20.40593  -10.34103 7.01113   1.000 22.48430  ? 214 TRP A CZ2  1 
ATOM   3248 C  CZ3  . TRP A 1 222 ? 20.07854  -7.94588  7.19454   1.000 19.36538  ? 214 TRP A CZ3  1 
ATOM   3249 C  CH2  . TRP A 1 222 ? 20.91669  -9.07398  7.09930   1.000 22.59852  ? 214 TRP A CH2  1 
ATOM   3250 H  H    . TRP A 1 222 ? 14.65715  -9.92529  9.32248   1.000 18.59745  ? 214 TRP A H    1 
ATOM   3251 H  HA   . TRP A 1 222 ? 16.30130  -7.91928  8.73362   1.000 20.11704  ? 214 TRP A HA   1 
ATOM   3252 H  HB2  . TRP A 1 222 ? 14.80054  -9.64762  7.10966   1.000 17.16562  ? 214 TRP A HB2  1 
ATOM   3253 H  HB3  . TRP A 1 222 ? 15.55433  -8.40350  6.46982   1.000 17.16562  ? 214 TRP A HB3  1 
ATOM   3254 H  HD1  . TRP A 1 222 ? 16.19679  -11.81016 7.01627   1.000 27.84354  ? 214 TRP A HD1  1 
ATOM   3255 H  HE1  . TRP A 1 222 ? 18.52717  -12.40558 6.89186   1.000 24.96313  ? 214 TRP A HE1  1 
ATOM   3256 H  HE3  . TRP A 1 222 ? 18.16823  -7.32263  7.25753   1.000 19.85673  ? 214 TRP A HE3  1 
ATOM   3257 H  HZ2  . TRP A 1 222 ? 20.96176  -11.08329 6.94035   1.000 26.95797  ? 214 TRP A HZ2  1 
ATOM   3258 H  HZ3  . TRP A 1 222 ? 20.45802  -7.09887  7.25339   1.000 23.21527  ? 214 TRP A HZ3  1 
ATOM   3259 H  HH2  . TRP A 1 222 ? 21.83907  -8.95518  7.09625   1.000 27.09503  ? 214 TRP A HH2  1 
ATOM   3260 N  N    . ILE A 1 223 ? 13.15869  -7.36898  8.58638   1.000 15.03936  ? 215 ILE A N    1 
ATOM   3261 C  CA   . ILE A 1 223 ? 12.21507  -6.25561  8.51681   1.000 17.11285  ? 215 ILE A CA   1 
ATOM   3262 C  C    . ILE A 1 223 ? 12.44670  -5.28249  9.67110   1.000 18.30911  ? 215 ILE A C    1 
ATOM   3263 O  O    . ILE A 1 223 ? 12.30059  -4.05891  9.51301   1.000 16.63977  ? 215 ILE A O    1 
ATOM   3264 C  CB   . ILE A 1 223 ? 10.76769  -6.77860  8.48680   1.000 17.15345  ? 215 ILE A CB   1 
ATOM   3265 C  CG1  . ILE A 1 223 ? 9.83456   -5.70552  7.91610   1.000 21.62107  ? 215 ILE A CG1  1 
ATOM   3266 C  CG2  . ILE A 1 223 ? 10.29441  -7.15200  9.88791   1.000 15.52122  ? 215 ILE A CG2  1 
ATOM   3267 C  CD1  . ILE A 1 223 ? 9.97433   -5.51024  6.40224   1.000 21.47187  ? 215 ILE A CD1  1 
ATOM   3268 H  H    . ILE A 1 223 ? 12.81386  -8.13797  8.75770   1.000 18.02404  ? 215 ILE A H    1 
ATOM   3269 H  HA   . ILE A 1 223 ? 12.37070  -5.77328  7.68974   1.000 20.51223  ? 215 ILE A HA   1 
ATOM   3270 H  HB   . ILE A 1 223 ? 10.74940  -7.56805  7.92347   1.000 20.56095  ? 215 ILE A HB   1 
ATOM   3271 H  HG12 . ILE A 1 223 ? 8.91672   -5.96083  8.09853   1.000 25.92209  ? 215 ILE A HG12 1 
ATOM   3272 H  HG13 . ILE A 1 223 ? 10.03454  -4.85827  8.34396   1.000 25.92209  ? 215 ILE A HG13 1 
ATOM   3273 H  HG21 . ILE A 1 223 ? 9.42316   -7.57375  9.82500   1.000 18.60227  ? 215 ILE A HG21 1 
ATOM   3274 H  HG22 . ILE A 1 223 ? 10.93189  -7.76708  10.28311  1.000 18.60227  ? 215 ILE A HG22 1 
ATOM   3275 H  HG23 . ILE A 1 223 ? 10.23420  -6.34709  10.42587  1.000 18.60227  ? 215 ILE A HG23 1 
ATOM   3276 H  HD11 . ILE A 1 223 ? 9.34380   -4.83283  6.11166   1.000 25.74305  ? 215 ILE A HD11 1 
ATOM   3277 H  HD12 . ILE A 1 223 ? 10.88014  -5.22634  6.20275   1.000 25.74305  ? 215 ILE A HD12 1 
ATOM   3278 H  HD13 . ILE A 1 223 ? 9.78544   -6.35086  5.95662   1.000 25.74305  ? 215 ILE A HD13 1 
ATOM   3279 N  N    . ARG A 1 224 ? 12.81703  -5.80502  10.84723  1.000 14.86037  ? 216 ARG A N    1 
ATOM   3280 C  CA   . ARG A 1 224 ? 13.05846  -4.94427  11.99810  1.000 15.65999  ? 216 ARG A CA   1 
ATOM   3281 C  C    . ARG A 1 224 ? 14.37857  -4.20848  11.84138  1.000 15.06677  ? 216 ARG A C    1 
ATOM   3282 O  O    . ARG A 1 224 ? 14.48072  -3.02573  12.17653  1.000 18.47025  ? 216 ARG A O    1 
ATOM   3283 C  CB   . ARG A 1 224 ? 13.02046  -5.77284  13.28497  1.000 16.92100  ? 216 ARG A CB   1 
ATOM   3284 C  CG   . ARG A 1 224 ? 11.60702  -6.21904  13.65770  1.000 16.25385  ? 216 ARG A CG   1 
ATOM   3285 C  CD   . ARG A 1 224 ? 11.56736  -7.25752  14.77614  1.000 22.06299  ? 216 ARG A CD   1 
ATOM   3286 N  NE   . ARG A 1 224 ? 10.18365  -7.58378  15.15628  1.000 17.77643  ? 216 ARG A NE   1 
ATOM   3287 C  CZ   . ARG A 1 224 ? 9.83681   -8.39252  16.15862  1.000 20.10700  ? 216 ARG A CZ   1 
ATOM   3288 N  NH1  . ARG A 1 224 ? 10.76393  -8.98202  16.89672  1.000 23.08438  ? 216 ARG A NH1  1 
ATOM   3289 N  NH2  . ARG A 1 224 ? 8.55773   -8.61865  16.42690  1.000 23.00244  ? 216 ARG A NH2  1 
ATOM   3290 H  H    . ARG A 1 224 ? 12.93260  -6.64372  10.99828  1.000 17.80926  ? 216 ARG A H    1 
ATOM   3291 H  HA   . ARG A 1 224 ? 12.35532  -4.27963  12.06693  1.000 18.76879  ? 216 ARG A HA   1 
ATOM   3292 H  HB2  . ARG A 1 224 ? 13.56469  -6.56686  13.16560  1.000 20.28201  ? 216 ARG A HB2  1 
ATOM   3293 H  HB3  . ARG A 1 224 ? 13.36933  -5.23822  14.01529  1.000 20.28201  ? 216 ARG A HB3  1 
ATOM   3294 H  HG2  . ARG A 1 224 ? 11.10258  -5.44548  13.95444  1.000 19.48143  ? 216 ARG A HG2  1 
ATOM   3295 H  HG3  . ARG A 1 224 ? 11.18584  -6.60992  12.87621  1.000 19.48143  ? 216 ARG A HG3  1 
ATOM   3296 H  HD2  . ARG A 1 224 ? 12.00149  -8.07104  14.47513  1.000 26.45240  ? 216 ARG A HD2  1 
ATOM   3297 H  HD3  . ARG A 1 224 ? 12.02418  -6.90700  15.55676  1.000 26.45240  ? 216 ARG A HD3  1 
ATOM   3298 H  HE   . ARG A 1 224 ? 9.55057   -7.22581  14.69730  1.000 21.30852  ? 216 ARG A HE   1 
ATOM   3299 H  HH11 . ARG A 1 224 ? 11.59666  -8.84473  16.73147  1.000 27.67806  ? 216 ARG A HH11 1 
ATOM   3300 H  HH12 . ARG A 1 224 ? 10.53360  -9.50234  17.54156  1.000 27.67806  ? 216 ARG A HH12 1 
ATOM   3301 H  HH21 . ARG A 1 224 ? 7.94608   -8.24287  15.95332  1.000 27.57974  ? 216 ARG A HH21 1 
ATOM   3302 H  HH22 . ARG A 1 224 ? 8.34002   -9.14106  17.07443  1.000 27.57974  ? 216 ARG A HH22 1 
ATOM   3303 N  N    . TYR A 1 225 ? 15.39572  -4.88184  11.31689  1.000 16.64024  ? 217 TYR A N    1 
ATOM   3304 C  CA   . TYR A 1 225 ? 16.63616  -4.19389  10.98143  1.000 17.88127  ? 217 TYR A CA   1 
ATOM   3305 C  C    . TYR A 1 225 ? 16.37197  -3.05407  10.01083  1.000 16.89951  ? 217 TYR A C    1 
ATOM   3306 O  O    . TYR A 1 225 ? 16.85359  -1.93026  10.20966  1.000 13.04565  ? 217 TYR A O    1 
ATOM   3307 C  CB   . TYR A 1 225 ? 17.61764  -5.19706  10.37221  1.000 15.12246  ? 217 TYR A CB   1 
ATOM   3308 C  CG   . TYR A 1 225 ? 19.09238  -4.90192  10.51511  1.000 16.99537  ? 217 TYR A CG   1 
ATOM   3309 C  CD1  . TYR A 1 225 ? 19.53027  -3.66676  10.91555  1.000 17.97293  ? 217 TYR A CD1  1 
ATOM   3310 C  CD2  . TYR A 1 225 ? 20.05336  -5.88490  10.22705  1.000 22.73512  ? 217 TYR A CD2  1 
ATOM   3311 C  CE1  . TYR A 1 225 ? 20.88921  -3.39984  11.04239  1.000 22.08194  ? 217 TYR A CE1  1 
ATOM   3312 C  CE2  . TYR A 1 225 ? 21.40785  -5.63520  10.35340  1.000 19.33765  ? 217 TYR A CE2  1 
ATOM   3313 C  CZ   . TYR A 1 225 ? 21.82659  -4.39000  10.76134  1.000 20.60394  ? 217 TYR A CZ   1 
ATOM   3314 O  OH   . TYR A 1 225 ? 23.18211  -4.13259  10.87744  1.000 17.02941  ? 217 TYR A OH   1 
ATOM   3315 H  H    . TYR A 1 225 ? 15.39434  -5.72498  11.14747  1.000 19.94510  ? 217 TYR A H    1 
ATOM   3316 H  HA   . TYR A 1 225 ? 17.02980  -3.82251  11.78643  1.000 21.43434  ? 217 TYR A HA   1 
ATOM   3317 H  HB2  . TYR A 1 225 ? 17.46211  -6.05776  10.79162  1.000 18.12377  ? 217 TYR A HB2  1 
ATOM   3318 H  HB3  . TYR A 1 225 ? 17.43388  -5.25327  9.42143   1.000 18.12377  ? 217 TYR A HB3  1 
ATOM   3319 H  HD1  . TYR A 1 225 ? 18.91127  -2.99898  11.10477  1.000 21.54432  ? 217 TYR A HD1  1 
ATOM   3320 H  HD2  . TYR A 1 225 ? 19.77178  -6.72490  9.94420   1.000 27.25896  ? 217 TYR A HD2  1 
ATOM   3321 H  HE1  . TYR A 1 225 ? 21.17263  -2.55732  11.31578  1.000 26.47514  ? 217 TYR A HE1  1 
ATOM   3322 H  HE2  . TYR A 1 225 ? 22.02849  -6.30161  10.16469  1.000 23.18199  ? 217 TYR A HE2  1 
ATOM   3323 H  HH   . TYR A 1 225 ? 23.62281  -4.82164  10.68612  1.000 20.41211  ? 217 TYR A HH   1 
ATOM   3324 N  N    . LEU A 1 226 ? 15.63379  -3.34286  8.92913   1.000 13.45436  ? 218 LEU A N    1 
ATOM   3325 C  CA   . LEU A 1 226 ? 15.33514  -2.33066  7.92035   1.000 15.02424  ? 218 LEU A CA   1 
ATOM   3326 C  C    . LEU A 1 226 ? 14.52336  -1.19469  8.51933   1.000 13.88782  ? 218 LEU A C    1 
ATOM   3327 O  O    . LEU A 1 226 ? 14.87856  -0.02027  8.37613   1.000 15.52781  ? 218 LEU A O    1 
ATOM   3328 C  CB   . LEU A 1 226 ? 14.57006  -2.94864  6.75271   1.000 17.98898  ? 218 LEU A CB   1 
ATOM   3329 C  CG   . LEU A 1 226 ? 15.36680  -3.82291  5.79552   1.000 25.44635  ? 218 LEU A CG   1 
ATOM   3330 C  CD1  . LEU A 1 226 ? 14.42233  -4.74444  4.99668   1.000 25.69241  ? 218 LEU A CD1  1 
ATOM   3331 C  CD2  . LEU A 1 226 ? 16.20087  -2.96958  4.87278   1.000 20.58472  ? 218 LEU A CD2  1 
ATOM   3332 H  H    . LEU A 1 226 ? 15.29719  -4.11607  8.76044   1.000 16.12204  ? 218 LEU A H    1 
ATOM   3333 H  HA   . LEU A 1 226 ? 16.17426  -1.97900  7.58403   1.000 18.00590  ? 218 LEU A HA   1 
ATOM   3334 H  HB2  . LEU A 1 226 ? 13.86144  -3.50102  7.11827   1.000 21.56359  ? 218 LEU A HB2  1 
ATOM   3335 H  HB3  . LEU A 1 226 ? 14.19056  -2.22642  6.22804   1.000 21.56359  ? 218 LEU A HB3  1 
ATOM   3336 H  HG   . LEU A 1 226 ? 15.97121  -4.38667  6.30322   1.000 30.51244  ? 218 LEU A HG   1 
ATOM   3337 H  HD11 . LEU A 1 226 ? 14.94913  -5.28425  4.38677   1.000 30.80770  ? 218 LEU A HD11 1 
ATOM   3338 H  HD12 . LEU A 1 226 ? 13.94233  -5.31720  5.61510   1.000 30.80770  ? 218 LEU A HD12 1 
ATOM   3339 H  HD13 . LEU A 1 226 ? 13.79545  -4.19785  4.49751   1.000 30.80770  ? 218 LEU A HD13 1 
ATOM   3340 H  HD21 . LEU A 1 226 ? 16.69001  -3.54633  4.26532   1.000 24.67848  ? 218 LEU A HD21 1 
ATOM   3341 H  HD22 . LEU A 1 226 ? 15.61508  -2.38147  4.37091   1.000 24.67848  ? 218 LEU A HD22 1 
ATOM   3342 H  HD23 . LEU A 1 226 ? 16.82138  -2.44499  5.40256   1.000 24.67848  ? 218 LEU A HD23 1 
ATOM   3343 N  N    . GLY A 1 227 ? 13.43274  -1.52677  9.21283   1.000 14.55001  ? 219 GLY A N    1 
ATOM   3344 C  CA   . GLY A 1 227 ? 12.58226  -0.48749  9.77418   1.000 13.72484  ? 219 GLY A CA   1 
ATOM   3345 C  C    . GLY A 1 227 ? 13.33808  0.49054   10.65522  1.000 22.22260  ? 219 GLY A C    1 
ATOM   3346 O  O    . GLY A 1 227 ? 13.14279  1.70707   10.56508  1.000 12.03110  ? 219 GLY A O    1 
ATOM   3347 H  H    . GLY A 1 227 ? 13.17068  -2.33104  9.36802   1.000 17.43682  ? 219 GLY A H    1 
ATOM   3348 H  HA2  . GLY A 1 227 ? 12.17110  0.01186   9.05134   1.000 16.44662  ? 219 GLY A HA2  1 
ATOM   3349 H  HA3  . GLY A 1 227 ? 11.88608  -0.90050  10.30865  1.000 16.44662  ? 219 GLY A HA3  1 
ATOM   3350 N  N    . ALA A 1 228 ? 14.20338  -0.03041  11.52652  1.000 15.81397  ? 220 ALA A N    1 
ATOM   3351 C  CA   . ALA A 1 228 ? 14.93461  0.82537   12.44919  1.000 18.72287  ? 220 ALA A CA   1 
ATOM   3352 C  C    . ALA A 1 228 ? 15.91930  1.71052   11.70060  1.000 19.87025  ? 220 ALA A C    1 
ATOM   3353 O  O    . ALA A 1 228 ? 15.92842  2.93109   11.88406  1.000 16.06221  ? 220 ALA A O    1 
ATOM   3354 C  CB   . ALA A 1 228 ? 15.65180  -0.03192  13.48993  1.000 18.18180  ? 220 ALA A CB   1 
ATOM   3355 H  H    . ALA A 1 228 ? 14.38138  -0.86851  11.60065  1.000 18.95357  ? 220 ALA A H    1 
ATOM   3356 H  HA   . ALA A 1 228 ? 14.30939  1.40173   12.91590  1.000 22.44426  ? 220 ALA A HA   1 
ATOM   3357 H  HB1  . ALA A 1 228 ? 16.13945  0.54831   14.09526  1.000 21.79497  ? 220 ALA A HB1  1 
ATOM   3358 H  HB2  . ALA A 1 228 ? 14.99373  -0.54633  13.98311  1.000 21.79497  ? 220 ALA A HB2  1 
ATOM   3359 H  HB3  . ALA A 1 228 ? 16.26712  -0.62956  13.03703  1.000 21.79497  ? 220 ALA A HB3  1 
ATOM   3360 N  N    . SER A 1 229 ? 16.76133  1.11471   10.84585  1.000 15.97810  ? 221 SER A N    1 
ATOM   3361 C  CA   . SER A 1 229 ? 17.79281  1.89809   10.16536  1.000 17.81329  ? 221 SER A CA   1 
ATOM   3362 C  C    . SER A 1 229 ? 17.18030  2.91766   9.21206   1.000 17.87663  ? 221 SER A C    1 
ATOM   3363 O  O    . SER A 1 229 ? 17.64212  4.06416   9.12729   1.000 16.69432  ? 221 SER A O    1 
ATOM   3364 C  CB   . SER A 1 229 ? 18.74974  0.97197   9.41122   1.000 16.83783  ? 221 SER A CB   1 
ATOM   3365 O  OG   . SER A 1 229 ? 19.42566  0.10631   10.31340  1.000 18.18216  ? 221 SER A OG   1 
ATOM   3366 H  H    . SER A 1 229 ? 16.75493  0.27769   10.64847  1.000 19.15053  ? 221 SER A H    1 
ATOM   3367 H  HA   . SER A 1 229 ? 18.30369  2.37983   10.83456  1.000 21.35276  ? 221 SER A HA   1 
ATOM   3368 H  HB2  . SER A 1 229 ? 18.24186  0.43778   8.78068   1.000 20.18221  ? 221 SER A HB2  1 
ATOM   3369 H  HB3  . SER A 1 229 ? 19.40410  1.50999   8.93872   1.000 20.18221  ? 221 SER A HB3  1 
ATOM   3370 H  HG   . SER A 1 229 ? 20.25386  0.13904   10.17692  1.000 21.79540  ? 221 SER A HG   1 
ATOM   3371 N  N    . ILE A 1 230 ? 16.14915  2.51758   8.47640   1.000 16.07740  ? 222 ILE A N    1 
ATOM   3372 C  CA   . ILE A 1 230 ? 15.51748  3.44991   7.55587   1.000 17.89539  ? 222 ILE A CA   1 
ATOM   3373 C  C    . ILE A 1 230 ? 14.88897  4.60065   8.32219   1.000 19.06338  ? 222 ILE A C    1 
ATOM   3374 O  O    . ILE A 1 230 ? 15.02910  5.76249   7.93142   1.000 16.60826  ? 222 ILE A O    1 
ATOM   3375 C  CB   . ILE A 1 230 ? 14.47958  2.72729   6.68337   1.000 18.81377  ? 222 ILE A CB   1 
ATOM   3376 C  CG1  . ILE A 1 230 ? 15.15772  1.71862   5.75294   1.000 24.31558  ? 222 ILE A CG1  1 
ATOM   3377 C  CG2  . ILE A 1 230 ? 13.66248  3.73268   5.86892   1.000 20.56425  ? 222 ILE A CG2  1 
ATOM   3378 C  CD1  . ILE A 1 230 ? 14.20644  0.66204   5.20718   1.000 22.22342  ? 222 ILE A CD1  1 
ATOM   3379 H  H    . ILE A 1 230 ? 15.80461  1.72976   8.49164   1.000 19.26969  ? 222 ILE A H    1 
ATOM   3380 H  HA   . ILE A 1 230 ? 16.20106  3.81063   6.96979   1.000 21.45127  ? 222 ILE A HA   1 
ATOM   3381 H  HB   . ILE A 1 230 ? 13.88011  2.24552   7.27450   1.000 22.55333  ? 222 ILE A HB   1 
ATOM   3382 H  HG12 . ILE A 1 230 ? 15.53737  2.19513   4.99816   1.000 29.15550  ? 222 ILE A HG12 1 
ATOM   3383 H  HG13 . ILE A 1 230 ? 15.85888  1.26223   6.24384   1.000 29.15550  ? 222 ILE A HG13 1 
ATOM   3384 H  HG21 . ILE A 1 230 ? 13.07965  3.24885   5.26302   1.000 24.65392  ? 222 ILE A HG21 1 
ATOM   3385 H  HG22 . ILE A 1 230 ? 13.13321  4.27427   6.47511   1.000 24.65392  ? 222 ILE A HG22 1 
ATOM   3386 H  HG23 . ILE A 1 230 ? 14.26870  4.29736   5.36442   1.000 24.65392  ? 222 ILE A HG23 1 
ATOM   3387 H  HD11 . ILE A 1 230 ? 14.69895  0.06597   4.62149   1.000 26.64492  ? 222 ILE A HD11 1 
ATOM   3388 H  HD12 . ILE A 1 230 ? 13.83120  0.16171   5.94865   1.000 26.64492  ? 222 ILE A HD12 1 
ATOM   3389 H  HD13 . ILE A 1 230 ? 13.49736  1.10111   4.71188   1.000 26.64492  ? 222 ILE A HD13 1 
ATOM   3390 N  N    . TYR A 1 231 ? 14.18431  4.30094   9.42506   1.000 22.99707  ? 223 TYR A N    1 
ATOM   3391 C  CA   . TYR A 1 231 ? 13.42677  5.33328   10.12990  1.000 16.23408  ? 223 TYR A CA   1 
ATOM   3392 C  C    . TYR A 1 231 ? 14.34258  6.29340   10.87620  1.000 18.31929  ? 223 TYR A C    1 
ATOM   3393 O  O    . TYR A 1 231 ? 14.22280  7.51433   10.72562  1.000 15.63607  ? 223 TYR A O    1 
ATOM   3394 C  CB   . TYR A 1 231 ? 12.44227  4.69815   11.10505  1.000 15.35773  ? 223 TYR A CB   1 
ATOM   3395 C  CG   . TYR A 1 231 ? 11.61796  5.69293   11.89724  1.000 16.06236  ? 223 TYR A CG   1 
ATOM   3396 C  CD1  . TYR A 1 231 ? 10.64093  6.47490   11.27327  1.000 15.97384  ? 223 TYR A CD1  1 
ATOM   3397 C  CD2  . TYR A 1 231 ? 11.80818  5.84588   13.26454  1.000 18.29684  ? 223 TYR A CD2  1 
ATOM   3398 C  CE1  . TYR A 1 231 ? 9.88206   7.36703   11.97504  1.000 14.43383  ? 223 TYR A CE1  1 
ATOM   3399 C  CE2  . TYR A 1 231 ? 11.04171  6.75575   13.98845  1.000 14.77428  ? 223 TYR A CE2  1 
ATOM   3400 C  CZ   . TYR A 1 231 ? 10.07913  7.50075   13.32619  1.000 17.08012  ? 223 TYR A CZ   1 
ATOM   3401 O  OH   . TYR A 1 231 ? 9.30194   8.37994   14.01486  1.000 16.73750  ? 223 TYR A OH   1 
ATOM   3402 H  H    . TYR A 1 231 ? 14.13207  3.51792   9.77685   1.000 27.57329  ? 223 TYR A H    1 
ATOM   3403 H  HA   . TYR A 1 231 ? 12.92734  5.83758   9.46872   1.000 19.45771  ? 223 TYR A HA   1 
ATOM   3404 H  HB2  . TYR A 1 231 ? 11.82706  4.13992   10.60426  1.000 18.40609  ? 223 TYR A HB2  1 
ATOM   3405 H  HB3  . TYR A 1 231 ? 12.93942  4.15798   11.73905  1.000 18.40609  ? 223 TYR A HB3  1 
ATOM   3406 H  HD1  . TYR A 1 231 ? 10.50468  6.38510   10.35770  1.000 19.14542  ? 223 TYR A HD1  1 
ATOM   3407 H  HD2  . TYR A 1 231 ? 12.45278  5.33643   13.70027  1.000 21.93302  ? 223 TYR A HD2  1 
ATOM   3408 H  HE1  . TYR A 1 231 ? 9.23798   7.87895   11.54146  1.000 17.29740  ? 223 TYR A HE1  1 
ATOM   3409 H  HE2  . TYR A 1 231 ? 11.17394  6.86181   14.90287  1.000 17.70595  ? 223 TYR A HE2  1 
ATOM   3410 H  HH   . TYR A 1 231 ? 9.38145   8.24802   14.84062  1.000 20.06182  ? 223 TYR A HH   1 
ATOM   3411 N  N    . PHE A 1 232 ? 15.24756  5.76317   11.70570  1.000 11.19466  ? 224 PHE A N    1 
ATOM   3412 C  CA   . PHE A 1 232 ? 16.03003  6.61480   12.59368  1.000 13.48625  ? 224 PHE A CA   1 
ATOM   3413 C  C    . PHE A 1 232 ? 17.14528  7.35883   11.87624  1.000 15.01380  ? 224 PHE A C    1 
ATOM   3414 O  O    . PHE A 1 232 ? 17.62281  8.36708   12.39858  1.000 22.76103  ? 224 PHE A O    1 
ATOM   3415 C  CB   . PHE A 1 232 ? 16.60185  5.78200   13.74262  1.000 19.05239  ? 224 PHE A CB   1 
ATOM   3416 C  CG   . PHE A 1 232 ? 15.56636  5.35324   14.73994  1.000 17.96282  ? 224 PHE A CG   1 
ATOM   3417 C  CD1  . PHE A 1 232 ? 14.98412  6.27071   15.58012  1.000 24.17245  ? 224 PHE A CD1  1 
ATOM   3418 C  CD2  . PHE A 1 232 ? 15.17300  4.03673   14.83515  1.000 14.25159  ? 224 PHE A CD2  1 
ATOM   3419 C  CE1  . PHE A 1 232 ? 14.02932  5.88814   16.49378  1.000 16.56040  ? 224 PHE A CE1  1 
ATOM   3420 C  CE2  . PHE A 1 232 ? 14.22070  3.65321   15.75534  1.000 16.86358  ? 224 PHE A CE2  1 
ATOM   3421 C  CZ   . PHE A 1 232 ? 13.63867  4.58571   16.57592  1.000 18.20027  ? 224 PHE A CZ   1 
ATOM   3422 H  H    . PHE A 1 232 ? 15.42206  4.92348   11.76954  1.000 13.41040  ? 224 PHE A H    1 
ATOM   3423 H  HA   . PHE A 1 232 ? 15.44411  7.28548   12.97810  1.000 16.16031  ? 224 PHE A HA   1 
ATOM   3424 H  HB2  . PHE A 1 232 ? 17.01150  4.98259   13.37652  1.000 22.83968  ? 224 PHE A HB2  1 
ATOM   3425 H  HB3  . PHE A 1 232 ? 17.26642  6.31018   14.21194  1.000 22.83968  ? 224 PHE A HB3  1 
ATOM   3426 H  HD1  . PHE A 1 232 ? 15.23909  7.16370   15.53064  1.000 28.98375  ? 224 PHE A HD1  1 
ATOM   3427 H  HD2  . PHE A 1 232 ? 15.55334  3.40055   14.27345  1.000 17.07872  ? 224 PHE A HD2  1 
ATOM   3428 H  HE1  . PHE A 1 232 ? 13.64871  6.52183   17.05810  1.000 19.84930  ? 224 PHE A HE1  1 
ATOM   3429 H  HE2  . PHE A 1 232 ? 13.97210  2.75939   15.81995  1.000 20.21310  ? 224 PHE A HE2  1 
ATOM   3430 H  HZ   . PHE A 1 232 ? 12.98247  4.33072   17.18361  1.000 21.81714  ? 224 PHE A HZ   1 
ATOM   3431 N  N    . SER A 1 233 ? 17.55867  6.90523   10.69472  1.000 16.53932  ? 225 SER A N    1 
ATOM   3432 C  CA   . SER A 1 233 ? 18.44831  7.69772   9.85987   1.000 17.20262  ? 225 SER A CA   1 
ATOM   3433 C  C    . SER A 1 233 ? 17.72146  8.84388   9.17814   1.000 20.33789  ? 225 SER A C    1 
ATOM   3434 O  O    . SER A 1 233 ? 18.37935  9.71852   8.61702   1.000 29.96359  ? 225 SER A O    1 
ATOM   3435 C  CB   . SER A 1 233 ? 19.10777  6.81633   8.79304   1.000 19.21664  ? 225 SER A CB   1 
ATOM   3436 O  OG   . SER A 1 233 ? 18.15560  6.34846   7.84574   1.000 16.81975  ? 225 SER A OG   1 
ATOM   3437 H  H    . SER A 1 233 ? 17.33759  6.14519   10.35845  1.000 19.82399  ? 225 SER A H    1 
ATOM   3438 H  HA   . SER A 1 233 ? 19.15417  8.06291   10.41601  1.000 20.61995  ? 225 SER A HA   1 
ATOM   3439 H  HB2  . SER A 1 233 ? 19.78196  7.33699   8.32905   1.000 23.03678  ? 225 SER A HB2  1 
ATOM   3440 H  HB3  . SER A 1 233 ? 19.51910  6.05282   9.22751   1.000 23.03678  ? 225 SER A HB3  1 
ATOM   3441 H  HG   . SER A 1 233 ? 17.75578  5.67482   8.14898   1.000 20.16051  ? 225 SER A HG   1 
ATOM   3442 N  N    . GLY A 1 234 ? 16.39266  8.85838   9.21305   1.000 18.53414  ? 226 GLY A N    1 
ATOM   3443 C  CA   . GLY A 1 234 ? 15.60021  9.83868   8.50098   1.000 20.89136  ? 226 GLY A CA   1 
ATOM   3444 C  C    . GLY A 1 234 ? 15.27073  9.49370   7.06301   1.000 26.23746  ? 226 GLY A C    1 
ATOM   3445 O  O    . GLY A 1 234 ? 14.62677  10.30521  6.38101   1.000 22.91431  ? 226 GLY A O    1 
ATOM   3446 H  H    . GLY A 1 234 ? 15.91910  8.29320   9.65568   1.000 22.21778  ? 226 GLY A H    1 
ATOM   3447 H  HA2  . GLY A 1 234 ? 14.76126  9.95784   8.97307   1.000 25.04644  ? 226 GLY A HA2  1 
ATOM   3448 H  HA3  . GLY A 1 234 ? 16.08263  10.68020  8.49701   1.000 25.04644  ? 226 GLY A HA3  1 
ATOM   3449 N  N    . LEU A 1 235 ? 15.67306  8.31366   6.58672   1.000 23.95732  ? 227 LEU A N    1 
ATOM   3450 C  CA   . LEU A 1 235 ? 15.50876  7.97703   5.17682   1.000 21.23508  ? 227 LEU A CA   1 
ATOM   3451 C  C    . LEU A 1 235 ? 14.04882  7.83028   4.78153   1.000 20.33290  ? 227 LEU A C    1 
ATOM   3452 O  O    . LEU A 1 235 ? 13.71167  8.02229   3.60701   1.000 23.93350  ? 227 LEU A O    1 
ATOM   3453 C  CB   . LEU A 1 235 ? 16.23437  6.67444   4.85992   1.000 18.68570  ? 227 LEU A CB   1 
ATOM   3454 C  CG   . LEU A 1 235 ? 17.38908  6.70346   3.87505   1.000 25.50143  ? 227 LEU A CG   1 
ATOM   3455 C  CD1  . LEU A 1 235 ? 17.84757  5.24236   3.60182   1.000 19.48225  ? 227 LEU A CD1  1 
ATOM   3456 C  CD2  . LEU A 1 235 ? 17.07807  7.38015   2.61064   1.000 24.11273  ? 227 LEU A CD2  1 
ATOM   3457 H  H    . LEU A 1 235 ? 16.04162  7.69534   7.05730   1.000 28.72559  ? 227 LEU A H    1 
ATOM   3458 H  HA   . LEU A 1 235 ? 15.89830  8.69713   4.65662   1.000 25.45891  ? 227 LEU A HA   1 
ATOM   3459 H  HB2  . LEU A 1 235 ? 16.59175  6.32956   5.69313   1.000 22.39965  ? 227 LEU A HB2  1 
ATOM   3460 H  HB3  . LEU A 1 235 ? 15.57981  6.05645   4.49864   1.000 22.39965  ? 227 LEU A HB3  1 
ATOM   3461 H  HG   . LEU A 1 235 ? 18.10483  7.22277   4.27369   1.000 30.57853  ? 227 LEU A HG   1 
ATOM   3462 H  HD11 . LEU A 1 235 ? 18.57858  5.25474   2.96435   1.000 23.35551  ? 227 LEU A HD11 1 
ATOM   3463 H  HD12 . LEU A 1 235 ? 18.14212  4.84274   4.43515   1.000 23.35551  ? 227 LEU A HD12 1 
ATOM   3464 H  HD13 . LEU A 1 235 ? 17.10125  4.73970   3.23955   1.000 23.35551  ? 227 LEU A HD13 1 
ATOM   3465 H  HD21 . LEU A 1 235 ? 17.83379  7.28892   2.00942   1.000 28.91209  ? 227 LEU A HD21 1 
ATOM   3466 H  HD22 . LEU A 1 235 ? 16.29164  6.96993   2.21802   1.000 28.91209  ? 227 LEU A HD22 1 
ATOM   3467 H  HD23 . LEU A 1 235 ? 16.90799  8.31848   2.78814   1.000 28.91209  ? 227 LEU A HD23 1 
ATOM   3468 N  N    . SER A 1 236 ? 13.17500  7.47545   5.72745   1.000 18.27214  ? 228 SER A N    1 
ATOM   3469 C  CA   . SER A 1 236 ? 11.76913  7.24193   5.40401   1.000 14.77302  ? 228 SER A CA   1 
ATOM   3470 C  C    . SER A 1 236 ? 10.98364  8.53020   5.13754   1.000 23.97483  ? 228 SER A C    1 
ATOM   3471 O  O    . SER A 1 236 ? 9.83923   8.46127   4.66659   1.000 18.19003  ? 228 SER A O    1 
ATOM   3472 C  CB   . SER A 1 236 ? 11.11105  6.46515   6.54131   1.000 16.45655  ? 228 SER A CB   1 
ATOM   3473 O  OG   . SER A 1 236 ? 11.01849  7.26846   7.69637   1.000 18.31001  ? 228 SER A OG   1 
ATOM   3474 H  H    . SER A 1 236 ? 13.37132  7.36460   6.55737   1.000 21.90338  ? 228 SER A H    1 
ATOM   3475 H  HA   . SER A 1 236 ? 11.72314  6.70761   4.59574   1.000 17.70443  ? 228 SER A HA   1 
ATOM   3476 H  HB2  . SER A 1 236 ? 10.21954  6.19728   6.26861   1.000 19.72467  ? 228 SER A HB2  1 
ATOM   3477 H  HB3  . SER A 1 236 ? 11.64621  5.68135   6.74175   1.000 19.72467  ? 228 SER A HB3  1 
ATOM   3478 H  HG   . SER A 1 236 ? 11.78150  7.53978   7.91952   1.000 21.94882  ? 228 SER A HG   1 
ATOM   3479 N  N    . GLU A 1 237 ? 11.55840  9.69755   5.41602   1.000 19.20155  ? 229 GLU A N    1 
ATOM   3480 C  CA   . GLU A 1 237 ? 10.81941  10.94533  5.26464   1.000 23.21617  ? 229 GLU A CA   1 
ATOM   3481 C  C    . GLU A 1 237 ? 10.41379  11.13776  3.81086   1.000 18.00472  ? 229 GLU A C    1 
ATOM   3482 O  O    . GLU A 1 237 ? 11.26502  11.15242  2.91918   1.000 21.00708  ? 229 GLU A O    1 
ATOM   3483 C  CB   . GLU A 1 237 ? 11.66899  12.12323  5.73740   1.000 26.81675  ? 229 GLU A CB   1 
ATOM   3484 C  CG   . GLU A 1 237 ? 10.98148  13.47128  5.60858   1.000 25.80752  ? 229 GLU A CG   1 
ATOM   3485 C  CD   . GLU A 1 237 ? 11.83059  14.60756  6.14255   1.000 40.74005  ? 229 GLU A CD   1 
ATOM   3486 O  OE1  . GLU A 1 237 ? 12.86725  14.32838  6.78127   1.000 38.88434  ? 229 GLU A OE1  1 
ATOM   3487 O  OE2  . GLU A 1 237 ? 11.45950  15.77925  5.92872   1.000 50.72265  ? 229 GLU A OE2  1 
ATOM   3488 H  H    . GLU A 1 237 ? 12.36748  9.79261   5.69162   1.000 23.01867  ? 229 GLU A H    1 
ATOM   3489 H  HA   . GLU A 1 237 ? 10.01899  10.91082  5.81148   1.000 27.83622  ? 229 GLU A HA   1 
ATOM   3490 H  HB2  . GLU A 1 237 ? 11.88889  11.99225  6.67302   1.000 32.15692  ? 229 GLU A HB2  1 
ATOM   3491 H  HB3  . GLU A 1 237 ? 12.48055  12.15390  5.20700   1.000 32.15692  ? 229 GLU A HB3  1 
ATOM   3492 H  HG2  . GLU A 1 237 ? 10.79882  13.64606  4.67211   1.000 30.94584  ? 229 GLU A HG2  1 
ATOM   3493 H  HG3  . GLU A 1 237 ? 10.15176  13.45353  6.11074   1.000 30.94584  ? 229 GLU A HG3  1 
ATOM   3494 N  N    . GLY A 1 238 ? 9.11419   11.28254  3.56982   1.000 23.68683  ? 230 GLY A N    1 
ATOM   3495 C  CA   . GLY A 1 238 ? 8.61196   11.52918  2.22928   1.000 24.56665  ? 230 GLY A CA   1 
ATOM   3496 C  C    . GLY A 1 238 ? 8.58600   10.33160  1.30277   1.000 24.50058  ? 230 GLY A C    1 
ATOM   3497 O  O    . GLY A 1 238 ? 8.35482   10.50321  0.09515   1.000 17.88093  ? 230 GLY A O    1 
ATOM   3498 H  H    . GLY A 1 238 ? 8.50131   11.24142  4.17171   1.000 28.40100  ? 230 GLY A H    1 
ATOM   3499 H  HA2  . GLY A 1 238 ? 7.70412   11.86369  2.29876   1.000 29.45679  ? 230 GLY A HA2  1 
ATOM   3500 H  HA3  . GLY A 1 238 ? 9.16741   12.20720  1.81374   1.000 29.45679  ? 230 GLY A HA3  1 
ATOM   3501 N  N    . ALA A 1 239 ? 8.83717   9.12864   1.81820   1.000 23.90559  ? 231 ALA A N    1 
ATOM   3502 C  CA   . ALA A 1 239 ? 8.85008   7.93762   0.97804   1.000 30.28293  ? 231 ALA A CA   1 
ATOM   3503 C  C    . ALA A 1 239 ? 7.42133   7.57356   0.60186   1.000 25.19465  ? 231 ALA A C    1 
ATOM   3504 O  O    . ALA A 1 239 ? 6.57184   7.38456   1.47841   1.000 25.63307  ? 231 ALA A O    1 
ATOM   3505 C  CB   . ALA A 1 239 ? 9.52780   6.76471   1.68845   1.000 19.89166  ? 231 ALA A CB   1 
ATOM   3506 H  H    . ALA A 1 239 ? 9.00232   8.97810   2.64866   1.000 28.66352  ? 231 ALA A H    1 
ATOM   3507 H  HA   . ALA A 1 239 ? 9.35870   8.12510   0.17365   1.000 36.31633  ? 231 ALA A HA   1 
ATOM   3508 H  HB1  . ALA A 1 239 ? 9.50824   5.98901   1.10637   1.000 23.84680  ? 231 ALA A HB1  1 
ATOM   3509 H  HB2  . ALA A 1 239 ? 10.44600  7.00480   1.88886   1.000 23.84680  ? 231 ALA A HB2  1 
ATOM   3510 H  HB3  . ALA A 1 239 ? 9.04893   6.57384   2.51013   1.000 23.84680  ? 231 ALA A HB3  1 
ATOM   3511 N  N    . SER A 1 240 ? 7.16228   7.45697   -0.69974  1.000 26.54718  ? 232 SER A N    1 
ATOM   3512 C  CA   . SER A 1 240 ? 5.84884   7.07507   -1.20070  1.000 23.61864  ? 232 SER A CA   1 
ATOM   3513 C  C    . SER A 1 240 ? 5.72731   5.59394   -1.49576  1.000 19.47808  ? 232 SER A C    1 
ATOM   3514 O  O    . SER A 1 240 ? 4.63446   5.04256   -1.32729  1.000 21.54079  ? 232 SER A O    1 
ATOM   3515 C  CB   . SER A 1 240 ? 5.51019   7.84624   -2.48183  1.000 32.68353  ? 232 SER A CB   1 
ATOM   3516 O  OG   . SER A 1 240 ? 5.43913   9.24214   -2.24538  1.000 29.58510  ? 232 SER A OG   1 
ATOM   3517 H  H    . SER A 1 240 ? 7.74139   7.59649   -1.32003  1.000 31.83343  ? 232 SER A H    1 
ATOM   3518 H  HA   . SER A 1 240 ? 5.19230   7.30903   -0.52607  1.000 28.31918  ? 232 SER A HA   1 
ATOM   3519 H  HB2  . SER A 1 240 ? 6.20027   7.67529   -3.14174  1.000 39.19704  ? 232 SER A HB2  1 
ATOM   3520 H  HB3  . SER A 1 240 ? 4.65126   7.54079   -2.81325  1.000 39.19704  ? 232 SER A HB3  1 
ATOM   3521 H  HG   . SER A 1 240 ? 6.21258   9.55934   -2.16314  1.000 35.47893  ? 232 SER A HG   1 
ATOM   3522 N  N    . PHE A 1 241 ? 6.81718   4.94430   -1.91970  1.000 18.68485  ? 233 PHE A N    1 
ATOM   3523 C  CA   . PHE A 1 241 ? 6.77432   3.57222   -2.39601  1.000 19.40664  ? 233 PHE A CA   1 
ATOM   3524 C  C    . PHE A 1 241 ? 7.94850   2.78145   -1.84468  1.000 20.32349  ? 233 PHE A C    1 
ATOM   3525 O  O    . PHE A 1 241 ? 9.05976   3.29997   -1.70641  1.000 17.95911  ? 233 PHE A O    1 
ATOM   3526 C  CB   . PHE A 1 241 ? 6.82422   3.49370   -3.93369  1.000 22.26349  ? 233 PHE A CB   1 
ATOM   3527 C  CG   . PHE A 1 241 ? 5.62845   4.09180   -4.61964  1.000 20.47627  ? 233 PHE A CG   1 
ATOM   3528 C  CD1  . PHE A 1 241 ? 4.37989   3.50282   -4.49634  1.000 28.29168  ? 233 PHE A CD1  1 
ATOM   3529 C  CD2  . PHE A 1 241 ? 5.75162   5.23741   -5.39126  1.000 22.61410  ? 233 PHE A CD2  1 
ATOM   3530 C  CE1  . PHE A 1 241 ? 3.26278   4.04802   -5.11583  1.000 29.64438  ? 233 PHE A CE1  1 
ATOM   3531 C  CE2  . PHE A 1 241 ? 4.63656   5.79258   -6.01963  1.000 35.65482  ? 233 PHE A CE2  1 
ATOM   3532 C  CZ   . PHE A 1 241 ? 3.38757   5.18893   -5.87952  1.000 26.46922  ? 233 PHE A CZ   1 
ATOM   3533 H  H    . PHE A 1 241 ? 7.60443   5.28997   -1.93847  1.000 22.39863  ? 233 PHE A H    1 
ATOM   3534 H  HA   . PHE A 1 241 ? 5.94911   3.17378   -2.07793  1.000 23.26478  ? 233 PHE A HA   1 
ATOM   3535 H  HB2  . PHE A 1 241 ? 7.61013   3.97052   -4.24335  1.000 26.69300  ? 233 PHE A HB2  1 
ATOM   3536 H  HB3  . PHE A 1 241 ? 6.87754   2.56113   -4.19515  1.000 26.69300  ? 233 PHE A HB3  1 
ATOM   3537 H  HD1  . PHE A 1 241 ? 4.28848   2.72842   -3.98954  1.000 33.92683  ? 233 PHE A HD1  1 
ATOM   3538 H  HD2  . PHE A 1 241 ? 6.58452   5.63901   -5.49072  1.000 27.11374  ? 233 PHE A HD2  1 
ATOM   3539 H  HE1  . PHE A 1 241 ? 2.43126   3.64376   -5.01553  1.000 35.55006  ? 233 PHE A HE1  1 
ATOM   3540 H  HE2  . PHE A 1 241 ? 4.72621   6.56408   -6.53114  1.000 42.76259  ? 233 PHE A HE2  1 
ATOM   3541 H  HZ   . PHE A 1 241 ? 2.64234   5.55416   -6.29920  1.000 31.73987  ? 233 PHE A HZ   1 
ATOM   3542 N  N    . ILE A 1 242 ? 7.68823   1.51864   -1.55042  1.000 16.15032  ? 234 ILE A N    1 
ATOM   3543 C  CA   . ILE A 1 242 ? 8.71219   0.52637   -1.26816  1.000 15.93934  ? 234 ILE A CA   1 
ATOM   3544 C  C    . ILE A 1 242 ? 8.54564   -0.56872  -2.30447  1.000 19.45757  ? 234 ILE A C    1 
ATOM   3545 O  O    . ILE A 1 242 ? 7.41438   -0.93099  -2.64891  1.000 22.14158  ? 234 ILE A O    1 
ATOM   3546 C  CB   . ILE A 1 242 ? 8.60623   -0.07094  0.14860   1.000 17.22124  ? 234 ILE A CB   1 
ATOM   3547 C  CG1  . ILE A 1 242 ? 8.49378   1.02863   1.19376   1.000 33.76728  ? 234 ILE A CG1  1 
ATOM   3548 C  CG2  . ILE A 1 242 ? 9.84250   -0.93492  0.45222   1.000 15.30331  ? 234 ILE A CG2  1 
ATOM   3549 C  CD1  . ILE A 1 242 ? 8.24786   0.49224   2.62088   1.000 31.53522  ? 234 ILE A CD1  1 
ATOM   3550 H  H    . ILE A 1 242 ? 6.89132   1.19837   -1.50616  1.000 19.35719  ? 234 ILE A H    1 
ATOM   3551 H  HA   . ILE A 1 242 ? 9.58691   0.93995   -1.33692  1.000 19.10402  ? 234 ILE A HA   1 
ATOM   3552 H  HB   . ILE A 1 242 ? 7.80632   -0.61865  0.18103   1.000 20.64229  ? 234 ILE A HB   1 
ATOM   3553 H  HG12 . ILE A 1 242 ? 9.32003   1.53667   1.20465   1.000 40.49755  ? 234 ILE A HG12 1 
ATOM   3554 H  HG13 . ILE A 1 242 ? 7.75127   1.60778   0.96105   1.000 40.49755  ? 234 ILE A HG13 1 
ATOM   3555 H  HG21 . ILE A 1 242 ? 9.73667   -1.34147  1.32653   1.000 18.34078  ? 234 ILE A HG21 1 
ATOM   3556 H  HG22 . ILE A 1 242 ? 9.92034   -1.62418  -0.22584  1.000 18.34078  ? 234 ILE A HG22 1 
ATOM   3557 H  HG23 . ILE A 1 242 ? 10.63179  -0.37114  0.44294   1.000 18.34078  ? 234 ILE A HG23 1 
ATOM   3558 H  HD11 . ILE A 1 242 ? 8.11200   1.24208   3.22103   1.000 37.81908  ? 234 ILE A HD11 1 
ATOM   3559 H  HD12 . ILE A 1 242 ? 7.45972   -0.07317  2.61428   1.000 37.81908  ? 234 ILE A HD12 1 
ATOM   3560 H  HD13 . ILE A 1 242 ? 9.02098   -0.02125  2.90284   1.000 37.81908  ? 234 ILE A HD13 1 
ATOM   3561 N  N    . THR A 1 243 ? 9.65855   -1.09781  -2.79990  1.000 15.63535  ? 235 THR A N    1 
ATOM   3562 C  CA   . THR A 1 243 ? 9.59115   -2.19865  -3.75221  1.000 22.51644  ? 235 THR A CA   1 
ATOM   3563 C  C    . THR A 1 243 ? 10.83927  -3.05981  -3.62246  1.000 22.05511  ? 235 THR A C    1 
ATOM   3564 O  O    . THR A 1 243 ? 11.85474  -2.63501  -3.06989  1.000 20.20829  ? 235 THR A O    1 
ATOM   3565 C  CB   . THR A 1 243 ? 9.44041   -1.68798  -5.19379  1.000 23.12753  ? 235 THR A CB   1 
ATOM   3566 O  OG1  . THR A 1 243 ? 9.11278   -2.77650  -6.07371  1.000 19.22742  ? 235 THR A OG1  1 
ATOM   3567 C  CG2  . THR A 1 243 ? 10.71928  -1.02813  -5.64091  1.000 15.19784  ? 235 THR A CG2  1 
ATOM   3568 H  H    . THR A 1 243 ? 10.45490  -0.83996  -2.60256  1.000 18.73923  ? 235 THR A H    1 
ATOM   3569 H  HA   . THR A 1 243 ? 8.82361   -2.75249  -3.53995  1.000 26.99654  ? 235 THR A HA   1 
ATOM   3570 H  HB   . THR A 1 243 ? 8.72505   -1.03431  -5.23701  1.000 27.72985  ? 235 THR A HB   1 
ATOM   3571 H  HG1  . THR A 1 243 ? 8.38591   -3.12641  -5.83955  1.000 23.04972  ? 235 THR A HG1  1 
ATOM   3572 H  HG21 . THR A 1 243 ? 10.59659  -0.62461  -6.51442  1.000 18.21422  ? 235 THR A HG21 1 
ATOM   3573 H  HG22 . THR A 1 243 ? 10.97539  -0.33847  -5.00872  1.000 18.21422  ? 235 THR A HG22 1 
ATOM   3574 H  HG23 . THR A 1 243 ? 11.43050  -1.68551  -5.69492  1.000 18.21422  ? 235 THR A HG23 1 
ATOM   3575 N  N    . THR A 1 244 ? 10.75282  -4.27750  -4.14907  1.000 19.92401  ? 236 THR A N    1 
ATOM   3576 C  CA   . THR A 1 244 ? 11.88514  -5.18187  -4.26859  1.000 19.45906  ? 236 THR A CA   1 
ATOM   3577 C  C    . THR A 1 244 ? 12.23401  -5.37226  -5.73803  1.000 21.95874  ? 236 THR A C    1 
ATOM   3578 O  O    . THR A 1 244 ? 11.44675  -5.04062  -6.62483  1.000 22.66763  ? 236 THR A O    1 
ATOM   3579 C  CB   . THR A 1 244 ? 11.56880  -6.53241  -3.62389  1.000 17.13223  ? 236 THR A CB   1 
ATOM   3580 O  OG1  . THR A 1 244 ? 10.30498  -7.02104  -4.09338  1.000 26.43254  ? 236 THR A OG1  1 
ATOM   3581 C  CG2  . THR A 1 244 ? 11.48347  -6.37757  -2.10572  1.000 14.58198  ? 236 THR A CG2  1 
ATOM   3582 H  H    . THR A 1 244 ? 10.02141  -4.61150  -4.45414  1.000 23.88562  ? 236 THR A H    1 
ATOM   3583 H  HA   . THR A 1 244 ? 12.65703  -4.80684  -3.81644  1.000 23.32768  ? 236 THR A HA   1 
ATOM   3584 H  HB   . THR A 1 244 ? 12.26870  -7.16413  -3.85188  1.000 20.53548  ? 236 THR A HB   1 
ATOM   3585 H  HG1  . THR A 1 244 ? 9.73484   -6.98102  -3.47779  1.000 31.69586  ? 236 THR A HG1  1 
ATOM   3586 H  HG21 . THR A 1 244 ? 11.27045  -7.23091  -1.69666  1.000 17.47518  ? 236 THR A HG21 1 
ATOM   3587 H  HG22 . THR A 1 244 ? 12.33213  -6.06394  -1.75600  1.000 17.47518  ? 236 THR A HG22 1 
ATOM   3588 H  HG23 . THR A 1 244 ? 10.79224  -5.73703  -1.87590  1.000 17.47518  ? 236 THR A HG23 1 
ATOM   3589 N  N    . TYR A 1 245 ? 13.43244  -5.89485  -5.98593  1.000 20.69582  ? 237 TYR A N    1 
ATOM   3590 C  CA   . TYR A 1 245 ? 13.89907  -6.17474  -7.33483  1.000 22.57531  ? 237 TYR A CA   1 
ATOM   3591 C  C    . TYR A 1 245 ? 13.42824  -7.57962  -7.70571  1.000 24.84748  ? 237 TYR A C    1 
ATOM   3592 O  O    . TYR A 1 245 ? 12.53087  -8.12523  -7.06007  1.000 24.39140  ? 237 TYR A O    1 
ATOM   3593 C  CB   . TYR A 1 245 ? 15.41783  -5.99888  -7.39780  1.000 23.85014  ? 237 TYR A CB   1 
ATOM   3594 C  CG   . TYR A 1 245 ? 15.97400  -5.90766  -8.79922  1.000 19.21050  ? 237 TYR A CG   1 
ATOM   3595 C  CD1  . TYR A 1 245 ? 15.43992  -5.02408  -9.72907  1.000 19.98123  ? 237 TYR A CD1  1 
ATOM   3596 C  CD2  . TYR A 1 245 ? 17.02106  -6.72768  -9.20107  1.000 21.29447  ? 237 TYR A CD2  1 
ATOM   3597 C  CE1  . TYR A 1 245 ? 15.94149  -4.94817  -11.01190 1.000 17.33339  ? 237 TYR A CE1  1 
ATOM   3598 C  CE2  . TYR A 1 245 ? 17.53394  -6.66479  -10.50663 1.000 18.03020  ? 237 TYR A CE2  1 
ATOM   3599 C  CZ   . TYR A 1 245 ? 16.99200  -5.76553  -11.39705 1.000 20.20755  ? 237 TYR A CZ   1 
ATOM   3600 O  OH   . TYR A 1 245 ? 17.49010  -5.69010  -12.67917 1.000 20.85593  ? 237 TYR A OH   1 
ATOM   3601 H  H    . TYR A 1 245 ? 14.00277  -6.09912  -5.37551  1.000 24.81179  ? 237 TYR A H    1 
ATOM   3602 H  HA   . TYR A 1 245 ? 13.50604  -5.54012  -7.95426  1.000 27.06719  ? 237 TYR A HA   1 
ATOM   3603 H  HB2  . TYR A 1 245 ? 15.65464  -5.18071  -6.93366  1.000 28.59698  ? 237 TYR A HB2  1 
ATOM   3604 H  HB3  . TYR A 1 245 ? 15.83615  -6.75917  -6.96437  1.000 28.59698  ? 237 TYR A HB3  1 
ATOM   3605 H  HD1  . TYR A 1 245 ? 14.73176  -4.47410  -9.48224  1.000 23.95429  ? 237 TYR A HD1  1 
ATOM   3606 H  HD2  . TYR A 1 245 ? 17.38884  -7.32904  -8.59444  1.000 25.53018  ? 237 TYR A HD2  1 
ATOM   3607 H  HE1  . TYR A 1 245 ? 15.57394  -4.34740  -11.61925 1.000 20.77688  ? 237 TYR A HE1  1 
ATOM   3608 H  HE2  . TYR A 1 245 ? 18.23065  -7.22334  -10.76646 1.000 21.61305  ? 237 TYR A HE2  1 
ATOM   3609 H  HH   . TYR A 1 245 ? 18.04578  -6.30667  -12.80824 1.000 25.00393  ? 237 TYR A HH   1 
ATOM   3610 N  N    . VAL A 1 246 ? 14.02525  -8.17990  -8.72950  1.000 21.75098  ? 238 VAL A N    1 
ATOM   3611 C  CA   . VAL A 1 246 ? 13.61843  -9.49029  -9.20800  1.000 22.67051  ? 238 VAL A CA   1 
ATOM   3612 C  C    . VAL A 1 246 ? 14.84403  -10.38581 -9.28357  1.000 19.93708  ? 238 VAL A C    1 
ATOM   3613 O  O    . VAL A 1 246 ? 15.95423  -9.94199  -9.59628  1.000 19.03307  ? 238 VAL A O    1 
ATOM   3614 C  CB   . VAL A 1 246 ? 12.91947  -9.42754  -10.58838 1.000 19.71774  ? 238 VAL A CB   1 
ATOM   3615 C  CG1  . VAL A 1 246 ? 11.46511  -9.04705  -10.43718 1.000 26.60041  ? 238 VAL A CG1  1 
ATOM   3616 C  CG2  . VAL A 1 246 ? 13.65174  -8.44690  -11.51989 1.000 18.40998  ? 238 VAL A CG2  1 
ATOM   3617 H  H    . VAL A 1 246 ? 14.68078  -7.83933  -9.16984  1.000 26.07799  ? 238 VAL A H    1 
ATOM   3618 H  HA   . VAL A 1 246 ? 12.99287  -9.86959  -8.57105  1.000 27.18142  ? 238 VAL A HA   1 
ATOM   3619 H  HB   . VAL A 1 246 ? 12.95269  -10.30764 -10.99485 1.000 23.63810  ? 238 VAL A HB   1 
ATOM   3620 H  HG11 . VAL A 1 246 ? 11.04696  -9.04356  -11.31242 1.000 31.89730  ? 238 VAL A HG11 1 
ATOM   3621 H  HG12 . VAL A 1 246 ? 11.02703  -9.69535  -9.86387  1.000 31.89730  ? 238 VAL A HG12 1 
ATOM   3622 H  HG13 . VAL A 1 246 ? 11.40940  -8.16365  -10.04045 1.000 31.89730  ? 238 VAL A HG13 1 
ATOM   3623 H  HG21 . VAL A 1 246 ? 13.23151  -8.46800  -12.39388 1.000 22.06878  ? 238 VAL A HG21 1 
ATOM   3624 H  HG22 . VAL A 1 246 ? 13.59372  -7.55355  -11.14645 1.000 22.06878  ? 238 VAL A HG22 1 
ATOM   3625 H  HG23 . VAL A 1 246 ? 14.58104  -8.71509  -11.59313 1.000 22.06878  ? 238 VAL A HG23 1 
ATOM   3626 N  N    . GLY A 1 247 ? 14.63092  -11.66042 -9.00657  1.000 18.76188  ? 239 GLY A N    1 
ATOM   3627 C  CA   . GLY A 1 247 ? 15.66029  -12.65086 -9.24040  1.000 20.82457  ? 239 GLY A CA   1 
ATOM   3628 C  C    . GLY A 1 247 ? 15.97982  -12.78773 -10.71550 1.000 24.46604  ? 239 GLY A C    1 
ATOM   3629 O  O    . GLY A 1 247 ? 15.28267  -12.28090 -11.59566 1.000 18.11447  ? 239 GLY A O    1 
ATOM   3630 H  H    . GLY A 1 247 ? 13.89929  -11.97593 -8.68288  1.000 22.49107  ? 239 GLY A H    1 
ATOM   3631 H  HA2  . GLY A 1 247 ? 16.46970  -12.39376 -8.77173  1.000 24.96629  ? 239 GLY A HA2  1 
ATOM   3632 H  HA3  . GLY A 1 247 ? 15.36277  -13.51210 -8.90775  1.000 24.96629  ? 239 GLY A HA3  1 
ATOM   3633 N  N    . HIS A 1 248 ? 17.08278  -13.49223 -10.98529 1.000 24.43543  ? 240 HIS A N    1 
ATOM   3634 C  CA   . HIS A 1 248 ? 17.54978  -13.62920 -12.35804 1.000 22.45005  ? 240 HIS A CA   1 
ATOM   3635 C  C    . HIS A 1 248 ? 16.67871  -14.58294 -13.16800 1.000 21.24025  ? 240 HIS A C    1 
ATOM   3636 O  O    . HIS A 1 248 ? 16.64870  -14.47810 -14.39498 1.000 26.55319  ? 240 HIS A O    1 
ATOM   3637 C  CB   . HIS A 1 248 ? 18.99718  -14.11880 -12.37525 1.000 25.90036  ? 240 HIS A CB   1 
ATOM   3638 C  CG   . HIS A 1 248 ? 19.14235  -15.57013 -12.02125 1.000 34.06690  ? 240 HIS A CG   1 
ATOM   3639 N  ND1  . HIS A 1 248 ? 19.11438  -16.57825 -12.96248 1.000 34.99276  ? 240 HIS A ND1  1 
ATOM   3640 C  CD2  . HIS A 1 248 ? 19.29938  -16.18248 -10.82321 1.000 32.29100  ? 240 HIS A CD2  1 
ATOM   3641 C  CE1  . HIS A 1 248 ? 19.25547  -17.74674 -12.36033 1.000 34.89285  ? 240 HIS A CE1  1 
ATOM   3642 N  NE2  . HIS A 1 248 ? 19.37431  -17.53403 -11.06222 1.000 32.89557  ? 240 HIS A NE2  1 
ATOM   3643 H  H    . HIS A 1 248 ? 17.56770  -13.89238 -10.39849 1.000 29.29933  ? 240 HIS A H    1 
ATOM   3644 H  HA   . HIS A 1 248 ? 17.52196  -12.75760 -12.78283 1.000 26.91687  ? 240 HIS A HA   1 
ATOM   3645 H  HB2  . HIS A 1 248 ? 19.35960  -13.99255 -13.26610 1.000 31.05725  ? 240 HIS A HB2  1 
ATOM   3646 H  HB3  . HIS A 1 248 ? 19.50943  -13.60352 -11.73260 1.000 31.05725  ? 240 HIS A HB3  1 
ATOM   3647 H  HD2  . HIS A 1 248 ? 19.34754  -15.76584 -9.99315  1.000 38.72601  ? 240 HIS A HD2  1 
ATOM   3648 H  HE1  . HIS A 1 248 ? 19.26877  -18.57690 -12.77933 1.000 41.84823  ? 240 HIS A HE1  1 
ATOM   3649 N  N    . ASN A 1 249 ? 15.95456  -15.48644 -12.51031 1.000 30.24692  ? 241 ASN A N    1 
ATOM   3650 C  CA   . ASN A 1 249 ? 15.18613  -16.53342 -13.17657 1.000 28.68718  ? 241 ASN A CA   1 
ATOM   3651 C  C    . ASN A 1 249 ? 13.80564  -16.00213 -13.54873 1.000 23.33140  ? 241 ASN A C    1 
ATOM   3652 O  O    . ASN A 1 249 ? 13.00136  -15.67732 -12.67112 1.000 23.39500  ? 241 ASN A O    1 
ATOM   3653 C  CB   . ASN A 1 249 ? 15.06332  -17.75399 -12.26020 1.000 27.61132  ? 241 ASN A CB   1 
ATOM   3654 C  CG   . ASN A 1 249 ? 14.59128  -18.99611 -12.97824 1.000 30.73329  ? 241 ASN A CG   1 
ATOM   3655 O  OD1  . ASN A 1 249 ? 14.48704  -20.07929 -12.38519 1.000 51.54075  ? 241 ASN A OD1  1 
ATOM   3656 N  ND2  . ASN A 1 249 ? 14.29108  -18.85664 -14.25287 1.000 44.20441  ? 241 ASN A ND2  1 
ATOM   3657 H  H    . ASN A 1 249 ? 15.89110  -15.51389 -11.65309 1.000 36.27312  ? 241 ASN A H    1 
ATOM   3658 H  HA   . ASN A 1 249 ? 15.63619  -16.79604 -13.99472 1.000 34.40143  ? 241 ASN A HA   1 
ATOM   3659 H  HB2  . ASN A 1 249 ? 15.93244  -17.94556 -11.87442 1.000 33.11040  ? 241 ASN A HB2  1 
ATOM   3660 H  HB3  . ASN A 1 249 ? 14.42477  -17.55586 -11.55742 1.000 33.11040  ? 241 ASN A HB3  1 
ATOM   3661 H  HD21 . ASN A 1 249 ? 14.36868  -18.08830 -14.63134 1.000 53.02211  ? 241 ASN A HD21 1 
ATOM   3662 H  HD22 . ASN A 1 249 ? 14.01744  -19.53390 -14.70680 1.000 53.02211  ? 241 ASN A HD22 1 
ATOM   3663 N  N    . ALA A 1 250 ? 13.53484  -15.91912 -14.85278 1.000 20.38996  ? 242 ALA A N    1 
ATOM   3664 C  CA   . ALA A 1 250 ? 12.21246  -15.49261 -15.29334 1.000 25.08374  ? 242 ALA A CA   1 
ATOM   3665 C  C    . ALA A 1 250 ? 11.12714  -16.44681 -14.81102 1.000 22.14675  ? 242 ALA A C    1 
ATOM   3666 O  O    . ALA A 1 250 ? 9.97737   -16.03478 -14.63006 1.000 19.46074  ? 242 ALA A O    1 
ATOM   3667 C  CB   . ALA A 1 250 ? 12.18944  -15.37334 -16.81603 1.000 21.61652  ? 242 ALA A CB   1 
ATOM   3668 H  H    . ALA A 1 250 ? 14.08762  -16.10032 -15.48618 1.000 24.44476  ? 242 ALA A H    1 
ATOM   3669 H  HA   . ALA A 1 250 ? 12.02050  -14.61742 -14.92174 1.000 30.07730  ? 242 ALA A HA   1 
ATOM   3670 H  HB1  . ALA A 1 250 ? 11.30617  -15.08742 -17.09708 1.000 25.91663  ? 242 ALA A HB1  1 
ATOM   3671 H  HB2  . ALA A 1 250 ? 12.85176  -14.72048 -17.09171 1.000 25.91663  ? 242 ALA A HB2  1 
ATOM   3672 H  HB3  . ALA A 1 250 ? 12.39610  -16.23816 -17.20370 1.000 25.91663  ? 242 ALA A HB3  1 
ATOM   3673 N  N    . GLU A 1 251 ? 11.46808  -17.71221 -14.58011 1.000 17.23784  ? 243 GLU A N    1 
ATOM   3674 C  CA   . GLU A 1 251 ? 10.49257  -18.69867 -14.13347 1.000 22.71025  ? 243 GLU A CA   1 
ATOM   3675 C  C    . GLU A 1 251 ? 10.20365  -18.63495 -12.63628 1.000 27.27700  ? 243 GLU A C    1 
ATOM   3676 O  O    . GLU A 1 251 ? 9.21097   -19.22333 -12.19386 1.000 16.49668  ? 243 GLU A O    1 
ATOM   3677 C  CB   . GLU A 1 251 ? 10.98472  -20.10463 -14.49366 1.000 30.35649  ? 243 GLU A CB   1 
ATOM   3678 C  CG   . GLU A 1 251 ? 11.30099  -20.31651 -15.97871 1.000 21.17584  ? 243 GLU A CG   1 
ATOM   3679 C  CD   . GLU A 1 251 ? 10.05491  -20.24551 -16.85825 1.000 27.64858  ? 243 GLU A CD   1 
ATOM   3680 O  OE1  . GLU A 1 251 ? 8.92992   -20.22281 -16.32031 1.000 29.09047  ? 243 GLU A OE1  1 
ATOM   3681 O  OE2  . GLU A 1 251 ? 10.19081  -20.19588 -18.09469 1.000 32.15188  ? 243 GLU A OE2  1 
ATOM   3682 H  H    . GLU A 1 251 ? 12.26336  -18.02525 -14.67569 1.000 20.66222  ? 243 GLU A H    1 
ATOM   3683 H  HA   . GLU A 1 251 ? 9.65618   -18.53409 -14.59637 1.000 27.22912  ? 243 GLU A HA   1 
ATOM   3684 H  HB2  . GLU A 1 251 ? 11.79695  -20.28332 -13.99442 1.000 36.40460  ? 243 GLU A HB2  1 
ATOM   3685 H  HB3  . GLU A 1 251 ? 10.29714  -20.74330 -14.24821 1.000 36.40460  ? 243 GLU A HB3  1 
ATOM   3686 H  HG2  . GLU A 1 251 ? 11.91676  -19.62727 -16.27312 1.000 25.38782  ? 243 GLU A HG2  1 
ATOM   3687 H  HG3  . GLU A 1 251 ? 11.70228  -21.19184 -16.09556 1.000 25.38782  ? 243 GLU A HG3  1 
ATOM   3688 N  N    . ASP A 1 252 ? 11.02981  -17.93499 -11.85716 1.000 20.39011  ? 244 ASP A N    1 
ATOM   3689 C  CA   . ASP A 1 252 ? 10.84640  -17.81230 -10.41842 1.000 23.03361  ? 244 ASP A CA   1 
ATOM   3690 C  C    . ASP A 1 252 ? 11.54343  -16.54459 -9.94487  1.000 24.29405  ? 244 ASP A C    1 
ATOM   3691 O  O    . ASP A 1 252 ? 12.55905  -16.62271 -9.24120  1.000 24.02011  ? 244 ASP A O    1 
ATOM   3692 C  CB   . ASP A 1 252 ? 11.40354  -19.04109 -9.70277  1.000 31.47112  ? 244 ASP A CB   1 
ATOM   3693 C  CG   . ASP A 1 252 ? 11.01666  -19.08379 -8.24359  1.000 32.28275  ? 244 ASP A CG   1 
ATOM   3694 O  OD1  . ASP A 1 252 ? 10.19980  -18.24022 -7.81124  1.000 34.83768  ? 244 ASP A OD1  1 
ATOM   3695 O  OD2  . ASP A 1 252 ? 11.53313  -19.96067 -7.53074  1.000 37.21638  ? 244 ASP A OD2  1 
ATOM   3696 H  H    . ASP A 1 252 ? 11.71997  -17.51289 -12.14889 1.000 24.44495  ? 244 ASP A H    1 
ATOM   3697 H  HA   . ASP A 1 252 ? 9.90309   -17.75012 -10.20116 1.000 27.61714  ? 244 ASP A HA   1 
ATOM   3698 H  HB2  . ASP A 1 252 ? 11.05789  -19.84065 -10.12953 1.000 37.74216  ? 244 ASP A HB2  1 
ATOM   3699 H  HB3  . ASP A 1 252 ? 12.37192  -19.02811 -9.75735  1.000 37.74216  ? 244 ASP A HB3  1 
ATOM   3700 N  N    . PRO A 1 253 ? 11.04165  -15.36062 -10.31338 1.000 22.49739  ? 245 PRO A N    1 
ATOM   3701 C  CA   . PRO A 1 253 ? 11.77061  -14.12430 -10.01571 1.000 23.30544  ? 245 PRO A CA   1 
ATOM   3702 C  C    . PRO A 1 253 ? 11.43749  -13.46793 -8.68950  1.000 21.72565  ? 245 PRO A C    1 
ATOM   3703 O  O    . PRO A 1 253 ? 12.10486  -12.47907 -8.35347  1.000 19.08184  ? 245 PRO A O    1 
ATOM   3704 C  CB   . PRO A 1 253 ? 11.36766  -13.20896 -11.18659 1.000 18.72499  ? 245 PRO A CB   1 
ATOM   3705 C  CG   . PRO A 1 253 ? 9.95466   -13.62806 -11.49018 1.000 26.78084  ? 245 PRO A CG   1 
ATOM   3706 C  CD   . PRO A 1 253 ? 9.86942   -15.11764 -11.17766 1.000 25.41220  ? 245 PRO A CD   1 
ATOM   3707 H  HA   . PRO A 1 253 ? 12.72555  -14.29191 -10.04564 1.000 27.94334  ? 245 PRO A HA   1 
ATOM   3708 H  HB2  . PRO A 1 253 ? 11.40889  -12.27852 -10.91551 1.000 22.44680  ? 245 PRO A HB2  1 
ATOM   3709 H  HB3  . PRO A 1 253 ? 11.95101  -13.35917 -11.94688 1.000 22.44680  ? 245 PRO A HB3  1 
ATOM   3710 H  HG2  . PRO A 1 253 ? 9.34016   -13.12647 -10.93188 1.000 32.11382  ? 245 PRO A HG2  1 
ATOM   3711 H  HG3  . PRO A 1 253 ? 9.76145   -13.46415 -12.42651 1.000 32.11382  ? 245 PRO A HG3  1 
ATOM   3712 H  HD2  . PRO A 1 253 ? 9.04666   -15.32361 -10.70697 1.000 30.47145  ? 245 PRO A HD2  1 
ATOM   3713 H  HD3  . PRO A 1 253 ? 9.92696   -15.64335 -11.99082 1.000 30.47145  ? 245 PRO A HD3  1 
ATOM   3714 N  N    . TYR A 1 254 ? 10.46159  -13.97894 -7.92958  1.000 17.99709  ? 246 TYR A N    1 
ATOM   3715 C  CA   . TYR A 1 254 ? 9.97108   -13.28340 -6.74466  1.000 20.14300  ? 246 TYR A CA   1 
ATOM   3716 C  C    . TYR A 1 254 ? 10.17538  -14.10489 -5.48159  1.000 17.91624  ? 246 TYR A C    1 
ATOM   3717 O  O    . TYR A 1 254 ? 9.38046   -14.00877 -4.54711  1.000 21.73083  ? 246 TYR A O    1 
ATOM   3718 C  CB   . TYR A 1 254 ? 8.49098   -12.91272 -6.88344  1.000 19.35873  ? 246 TYR A CB   1 
ATOM   3719 C  CG   . TYR A 1 254 ? 8.18265   -12.02290 -8.06797  1.000 19.95113  ? 246 TYR A CG   1 
ATOM   3720 C  CD1  . TYR A 1 254 ? 8.73299   -10.75848 -8.16764  1.000 20.02325  ? 246 TYR A CD1  1 
ATOM   3721 C  CD2  . TYR A 1 254 ? 7.34343   -12.45301 -9.09510  1.000 30.71940  ? 246 TYR A CD2  1 
ATOM   3722 C  CE1  . TYR A 1 254 ? 8.45791   -9.94573  -9.25437  1.000 24.64569  ? 246 TYR A CE1  1 
ATOM   3723 C  CE2  . TYR A 1 254 ? 7.06833   -11.64455 -10.18675 1.000 23.13681  ? 246 TYR A CE2  1 
ATOM   3724 C  CZ   . TYR A 1 254 ? 7.63426   -10.39689 -10.26055 1.000 26.28785  ? 246 TYR A CZ   1 
ATOM   3725 O  OH   . TYR A 1 254 ? 7.37615   -9.58766  -11.34518 1.000 30.46413  ? 246 TYR A OH   1 
ATOM   3726 H  H    . TYR A 1 254 ? 10.07041  -14.72897 -8.08464  1.000 21.57332  ? 246 TYR A H    1 
ATOM   3727 H  HA   . TYR A 1 254 ? 10.48145  -12.46286 -6.66019  1.000 24.14841  ? 246 TYR A HA   1 
ATOM   3728 H  HB2  . TYR A 1 254 ? 7.97540   -13.72794 -6.98583  1.000 23.20729  ? 246 TYR A HB2  1 
ATOM   3729 H  HB3  . TYR A 1 254 ? 8.21257   -12.44255 -6.08199  1.000 23.20729  ? 246 TYR A HB3  1 
ATOM   3730 H  HD1  . TYR A 1 254 ? 9.29606   -10.44941 -7.49509  1.000 24.00471  ? 246 TYR A HD1  1 
ATOM   3731 H  HD2  . TYR A 1 254 ? 6.96067   -13.29921 -9.04670  1.000 36.84009  ? 246 TYR A HD2  1 
ATOM   3732 H  HE1  . TYR A 1 254 ? 8.82979   -9.09479  -9.30442  1.000 29.55164  ? 246 TYR A HE1  1 
ATOM   3733 H  HE2  . TYR A 1 254 ? 6.50521   -11.94509 -10.86312 1.000 27.74098  ? 246 TYR A HE2  1 
ATOM   3734 H  HH   . TYR A 1 254 ? 7.87914   -8.91513  -11.32801 1.000 36.53376  ? 246 TYR A HH   1 
ATOM   3735 N  N    . LYS A 1 255 ? 11.23552  -14.91387 -5.43401  1.000 16.97051  ? 247 LYS A N    1 
ATOM   3736 C  CA   . LYS A 1 255 ? 11.47328  -15.72278 -4.24453  1.000 23.50855  ? 247 LYS A CA   1 
ATOM   3737 C  C    . LYS A 1 255 ? 11.62084  -14.83887 -3.00681  1.000 30.53653  ? 247 LYS A C    1 
ATOM   3738 O  O    . LYS A 1 255 ? 11.01354  -15.10974 -1.96484  1.000 27.34378  ? 247 LYS A O    1 
ATOM   3739 C  CB   . LYS A 1 255 ? 12.70981  -16.60966 -4.42717  1.000 33.41203  ? 247 LYS A CB   1 
ATOM   3740 C  CG   . LYS A 1 255 ? 12.49653  -17.81744 -5.33969  1.000 48.17921  ? 247 LYS A CG   1 
ATOM   3741 C  CD   . LYS A 1 255 ? 11.92633  -19.04842 -4.61872  1.000 57.51289  ? 247 LYS A CD   1 
ATOM   3742 C  CE   . LYS A 1 255 ? 12.73975  -19.42331 -3.37460  1.000 69.68504  ? 247 LYS A CE   1 
ATOM   3743 N  NZ   . LYS A 1 255 ? 14.02223  -20.13742 -3.68023  1.000 66.90663  ? 247 LYS A NZ   1 
ATOM   3744 H  H    . LYS A 1 255 ? 11.81580  -15.00876 -6.06160  1.000 20.34142  ? 247 LYS A H    1 
ATOM   3745 H  HA   . LYS A 1 255 ? 10.71165  -16.30940 -4.11533  1.000 28.18707  ? 247 LYS A HA   1 
ATOM   3746 H  HB2  . LYS A 1 255 ? 13.42010  -16.07330 -4.81279  1.000 40.07125  ? 247 LYS A HB2  1 
ATOM   3747 H  HB3  . LYS A 1 255 ? 12.98105  -16.94388 -3.55790  1.000 40.07125  ? 247 LYS A HB3  1 
ATOM   3748 H  HG2  . LYS A 1 255 ? 11.87368  -17.57222 -6.04170  1.000 57.79187  ? 247 LYS A HG2  1 
ATOM   3749 H  HG3  . LYS A 1 255 ? 13.34921  -18.07101 -5.72639  1.000 57.79187  ? 247 LYS A HG3  1 
ATOM   3750 H  HD2  . LYS A 1 255 ? 11.01689  -18.86024 -4.33873  1.000 68.99228  ? 247 LYS A HD2  1 
ATOM   3751 H  HD3  . LYS A 1 255 ? 11.93686  -19.80548 -5.22505  1.000 68.99228  ? 247 LYS A HD3  1 
ATOM   3752 H  HE2  . LYS A 1 255 ? 12.96179  -18.61232 -2.89099  1.000 83.59885  ? 247 LYS A HE2  1 
ATOM   3753 H  HE3  . LYS A 1 255 ? 12.20337  -20.00677 -2.81533  1.000 83.59885  ? 247 LYS A HE3  1 
ATOM   3754 H  HZ1  . LYS A 1 255 ? 14.45854  -20.31605 -2.92536  1.000 80.26476  ? 247 LYS A HZ1  1 
ATOM   3755 H  HZ2  . LYS A 1 255 ? 13.85174  -20.90176 -4.10310  1.000 80.26476  ? 247 LYS A HZ2  1 
ATOM   3756 H  HZ3  . LYS A 1 255 ? 14.53751  -19.62937 -4.19838  1.000 80.26476  ? 247 LYS A HZ3  1 
ATOM   3757 N  N    . LEU A 1 256 ? 12.43157  -13.77831 -3.09888  1.000 24.27619  ? 248 LEU A N    1 
ATOM   3758 C  CA   . LEU A 1 256 ? 12.60166  -12.88662 -1.95261  1.000 24.63350  ? 248 LEU A CA   1 
ATOM   3759 C  C    . LEU A 1 256 ? 11.30835  -12.15235 -1.63034  1.000 26.23118  ? 248 LEU A C    1 
ATOM   3760 O  O    . LEU A 1 256 ? 10.84202  -12.16440 -0.48370  1.000 19.91372  ? 248 LEU A O    1 
ATOM   3761 C  CB   . LEU A 1 256 ? 13.72248  -11.88913 -2.22746  1.000 26.76484  ? 248 LEU A CB   1 
ATOM   3762 C  CG   . LEU A 1 256 ? 14.16371  -11.06472 -1.01778  1.000 26.15398  ? 248 LEU A CG   1 
ATOM   3763 C  CD1  . LEU A 1 256 ? 14.77384  -11.97706 0.05331   1.000 29.97869  ? 248 LEU A CD1  1 
ATOM   3764 C  CD2  . LEU A 1 256 ? 15.15443  -9.97926  -1.42173  1.000 30.10197  ? 248 LEU A CD2  1 
ATOM   3765 H  H    . LEU A 1 256 ? 12.88276  -13.55984 -3.79766  1.000 29.10823  ? 248 LEU A H    1 
ATOM   3766 H  HA   . LEU A 1 256 ? 12.84953  -13.41903 -1.18060  1.000 29.53701  ? 248 LEU A HA   1 
ATOM   3767 H  HB2  . LEU A 1 256 ? 14.49733  -12.37867 -2.54505  1.000 32.09461  ? 248 LEU A HB2  1 
ATOM   3768 H  HB3  . LEU A 1 256 ? 13.42007  -11.26843 -2.90877  1.000 32.09461  ? 248 LEU A HB3  1 
ATOM   3769 H  HG   . LEU A 1 256 ? 13.38542  -10.62490 -0.64131  1.000 31.36159  ? 248 LEU A HG   1 
ATOM   3770 H  HD11 . LEU A 1 256 ? 15.06711  -11.43359 0.80134   1.000 35.95124  ? 248 LEU A HD11 1 
ATOM   3771 H  HD12 . LEU A 1 256 ? 14.10156  -12.61094 0.34849   1.000 35.95124  ? 248 LEU A HD12 1 
ATOM   3772 H  HD13 . LEU A 1 256 ? 15.52977  -12.45026 -0.32819  1.000 35.95124  ? 248 LEU A HD13 1 
ATOM   3773 H  HD21 . LEU A 1 256 ? 15.41202  -9.47730  -0.63269  1.000 36.09918  ? 248 LEU A HD21 1 
ATOM   3774 H  HD22 . LEU A 1 256 ? 15.93544  -10.39619 -1.81810  1.000 36.09918  ? 248 LEU A HD22 1 
ATOM   3775 H  HD23 . LEU A 1 256 ? 14.73168  -9.38956  -2.06550  1.000 36.09918  ? 248 LEU A HD23 1 
ATOM   3776 N  N    . ALA A 1 257 ? 10.70586  -11.52048 -2.63757  1.000 21.55004  ? 249 ALA A N    1 
ATOM   3777 C  CA   . ALA A 1 257 ? 9.47741   -10.77770 -2.40915  1.000 20.78035  ? 249 ALA A CA   1 
ATOM   3778 C  C    . ALA A 1 257 ? 8.41849   -11.65685 -1.76943  1.000 19.98128  ? 249 ALA A C    1 
ATOM   3779 O  O    . ALA A 1 257 ? 7.66073   -11.19769 -0.90945  1.000 25.23892  ? 249 ALA A O    1 
ATOM   3780 C  CB   . ALA A 1 257 ? 8.96997   -10.20480 -3.72631  1.000 21.57388  ? 249 ALA A CB   1 
ATOM   3781 H  H    . ALA A 1 257 ? 10.98673  -11.50850 -3.45032  1.000 25.83686  ? 249 ALA A H    1 
ATOM   3782 H  HA   . ALA A 1 257 ? 9.65944   -10.03882 -1.80763  1.000 24.91324  ? 249 ALA A HA   1 
ATOM   3783 H  HB1  . ALA A 1 257 ? 8.14582   -9.71997  -3.56317  1.000 25.86547  ? 249 ALA A HB1  1 
ATOM   3784 H  HB2  . ALA A 1 257 ? 9.64043   -9.60487  -4.08891  1.000 25.86547  ? 249 ALA A HB2  1 
ATOM   3785 H  HB3  . ALA A 1 257 ? 8.80809   -10.93325 -4.34603  1.000 25.86547  ? 249 ALA A HB3  1 
ATOM   3786 N  N    . ASN A 1 258 ? 8.35250   -12.92841 -2.17037  1.000 18.07690  ? 250 ASN A N    1 
ATOM   3787 C  CA   . ASN A 1 258 ? 7.30815   -13.80084 -1.64753  1.000 16.23365  ? 250 ASN A CA   1 
ATOM   3788 C  C    . ASN A 1 258 ? 7.53215   -14.07427 -0.16732  1.000 18.05604  ? 250 ASN A C    1 
ATOM   3789 O  O    . ASN A 1 258 ? 6.58327   -14.10080 0.62255   1.000 23.16708  ? 250 ASN A O    1 
ATOM   3790 C  CB   . ASN A 1 258 ? 7.26665   -15.11046 -2.44245  1.000 16.86247  ? 250 ASN A CB   1 
ATOM   3791 C  CG   . ASN A 1 258 ? 6.65364   -14.94590 -3.82665  1.000 18.48522  ? 250 ASN A CG   1 
ATOM   3792 O  OD1  . ASN A 1 258 ? 5.91530   -14.01163 -4.07992  1.000 23.23138  ? 250 ASN A OD1  1 
ATOM   3793 N  ND2  . ASN A 1 258 ? 6.97188   -15.85332 -4.72497  1.000 26.26291  ? 250 ASN A ND2  1 
ATOM   3794 H  H    . ASN A 1 258 ? 8.88867   -13.29961 -2.73102  1.000 21.66910  ? 250 ASN A H    1 
ATOM   3795 H  HA   . ASN A 1 258 ? 6.44672   -13.36740 -1.75228  1.000 19.45719  ? 250 ASN A HA   1 
ATOM   3796 H  HB2  . ASN A 1 258 ? 8.17191   -15.44069 -2.55359  1.000 20.21177  ? 250 ASN A HB2  1 
ATOM   3797 H  HB3  . ASN A 1 258 ? 6.73460   -15.75858 -1.95485  1.000 20.21177  ? 250 ASN A HB3  1 
ATOM   3798 H  HD21 . ASN A 1 258 ? 6.64997   -15.80195 -5.52080  1.000 31.49231  ? 250 ASN A HD21 1 
ATOM   3799 H  HD22 . ASN A 1 258 ? 7.50177   -16.49771 -4.51623  1.000 31.49231  ? 250 ASN A HD22 1 
ATOM   3800 N  N    . ILE A 1 259 ? 8.77954   -14.28989 0.23246   1.000 21.26621  ? 251 ILE A N    1 
ATOM   3801 C  CA   . ILE A 1 259 ? 9.03859   -14.53319 1.64518   1.000 18.68046  ? 251 ILE A CA   1 
ATOM   3802 C  C    . ILE A 1 259 ? 8.83927   -13.25683 2.45522   1.000 14.70452  ? 251 ILE A C    1 
ATOM   3803 O  O    . ILE A 1 259 ? 8.34832   -13.29538 3.58759   1.000 17.06932  ? 251 ILE A O    1 
ATOM   3804 C  CB   . ILE A 1 259 ? 10.45390  -15.09940 1.83846   1.000 18.97033  ? 251 ILE A CB   1 
ATOM   3805 C  CG1  . ILE A 1 259 ? 10.62947  -16.38908 1.04667   1.000 25.28456  ? 251 ILE A CG1  1 
ATOM   3806 C  CG2  . ILE A 1 259 ? 10.73090  -15.36280 3.30924   1.000 23.22352  ? 251 ILE A CG2  1 
ATOM   3807 C  CD1  . ILE A 1 259 ? 12.08513  -16.76486 0.82451   1.000 34.43720  ? 251 ILE A CD1  1 
ATOM   3808 H  H    . ILE A 1 259 ? 9.47214   -14.30036 -0.27724  1.000 25.49626  ? 251 ILE A H    1 
ATOM   3809 H  HA   . ILE A 1 259 ? 8.40156   -15.19300 1.96099   1.000 22.39336  ? 251 ILE A HA   1 
ATOM   3810 H  HB   . ILE A 1 259 ? 11.08327  -14.43825 1.51034   1.000 22.74121  ? 251 ILE A HB   1 
ATOM   3811 H  HG12 . ILE A 1 259 ? 10.20501  -17.11457 1.53081   1.000 30.31829  ? 251 ILE A HG12 1 
ATOM   3812 H  HG13 . ILE A 1 259 ? 10.21325  -16.28231 0.17704   1.000 30.31829  ? 251 ILE A HG13 1 
ATOM   3813 H  HG21 . ILE A 1 259 ? 11.54660  -15.88162 3.38899   1.000 27.84504  ? 251 ILE A HG21 1 
ATOM   3814 H  HG22 . ILE A 1 259 ? 10.83229  -14.51439 3.76838   1.000 27.84504  ? 251 ILE A HG22 1 
ATOM   3815 H  HG23 . ILE A 1 259 ? 9.98650   -15.85662 3.68729   1.000 27.84504  ? 251 ILE A HG23 1 
ATOM   3816 H  HD11 . ILE A 1 259 ? 12.12423  -17.60957 0.34930   1.000 41.30145  ? 251 ILE A HD11 1 
ATOM   3817 H  HD12 . ILE A 1 259 ? 12.51413  -16.07038 0.30053   1.000 41.30145  ? 251 ILE A HD12 1 
ATOM   3818 H  HD13 . ILE A 1 259 ? 12.52449  -16.84889 1.68521   1.000 41.30145  ? 251 ILE A HD13 1 
ATOM   3819 N  N    . MET A 1 260 ? 9.23346   -12.11416 1.90641   1.000 18.32849  ? 252 MET A N    1 
ATOM   3820 C  CA   . MET A 1 260 ? 9.18989   -10.84491 2.63054   1.000 22.57489  ? 252 MET A CA   1 
ATOM   3821 C  C    . MET A 1 260 ? 7.88688   -10.06412 2.43983   1.000 22.80117  ? 252 MET A C    1 
ATOM   3822 O  O    . MET A 1 260 ? 7.70920   -9.01218  3.07664   1.000 17.32798  ? 252 MET A O    1 
ATOM   3823 C  CB   . MET A 1 260 ? 10.35694  -9.96678  2.18093   1.000 19.84196  ? 252 MET A CB   1 
ATOM   3824 C  CG   . MET A 1 260 ? 11.73865  -10.49951 2.52529   1.000 19.49560  ? 252 MET A CG   1 
ATOM   3825 S  SD   . MET A 1 260 ? 11.92885  -11.19932 4.22845   1.000 24.28219  ? 252 MET A SD   1 
ATOM   3826 C  CE   . MET A 1 260 ? 11.79873  -9.80111  5.21562   1.000 28.20141  ? 252 MET A CE   1 
ATOM   3827 H  H    . MET A 1 260 ? 9.53502   -12.04475 1.10401   1.000 21.97100  ? 252 MET A H    1 
ATOM   3828 H  HA   . MET A 1 260 ? 9.28426   -11.04106 3.57580   1.000 27.06668  ? 252 MET A HA   1 
ATOM   3829 H  HB2  . MET A 1 260 ? 10.31489  -9.87197  1.21649   1.000 23.78716  ? 252 MET A HB2  1 
ATOM   3830 H  HB3  . MET A 1 260 ? 10.26735  -9.09845  2.60387   1.000 23.78716  ? 252 MET A HB3  1 
ATOM   3831 H  HG2  . MET A 1 260 ? 11.95744  -11.20648 1.89822   1.000 23.37154  ? 252 MET A HG2  1 
ATOM   3832 H  HG3  . MET A 1 260 ? 12.37512  -9.77242  2.44082   1.000 23.37154  ? 252 MET A HG3  1 
ATOM   3833 H  HE1  . MET A 1 260 ? 11.78910  -10.07190 6.14701   1.000 33.81851  ? 252 MET A HE1  1 
ATOM   3834 H  HE2  . MET A 1 260 ? 12.55954  -9.22352  5.04693   1.000 33.81851  ? 252 MET A HE2  1 
ATOM   3835 H  HE3  . MET A 1 260 ? 10.97575  -9.33621  4.99779   1.000 33.81851  ? 252 MET A HE3  1 
ATOM   3836 N  N    . GLU A 1 261 ? 6.97181   -10.55264 1.59413   1.000 20.21824  ? 253 GLU A N    1 
ATOM   3837 C  CA   . GLU A 1 261 ? 5.76117   -9.79018  1.27780   1.000 23.40658  ? 253 GLU A CA   1 
ATOM   3838 C  C    . GLU A 1 261 ? 4.99412   -9.40512  2.54070   1.000 17.89758  ? 253 GLU A C    1 
ATOM   3839 O  O    . GLU A 1 261 ? 4.62673   -8.23518  2.72153   1.000 16.00974  ? 253 GLU A O    1 
ATOM   3840 C  CB   . GLU A 1 261 ? 4.86011   -10.59488 0.32921   1.000 23.84554  ? 253 GLU A CB   1 
ATOM   3841 C  CG   . GLU A 1 261 ? 3.49872   -9.96813  0.08639   1.000 29.58559  ? 253 GLU A CG   1 
ATOM   3842 C  CD   . GLU A 1 261 ? 2.66450   -10.72421 -0.94235  1.000 22.78651  ? 253 GLU A CD   1 
ATOM   3843 O  OE1  . GLU A 1 261 ? 3.14071   -11.75191 -1.46162  1.000 29.50853  ? 253 GLU A OE1  1 
ATOM   3844 O  OE2  . GLU A 1 261 ? 1.53362   -10.27874 -1.23916  1.000 34.06909  ? 253 GLU A OE2  1 
ATOM   3845 H  H    . GLU A 1 261 ? 7.02781   -11.31278 1.19581   1.000 24.23870  ? 253 GLU A H    1 
ATOM   3846 H  HA   . GLU A 1 261 ? 6.02630   -8.97318  0.82712   1.000 28.06470  ? 253 GLU A HA   1 
ATOM   3847 H  HB2  . GLU A 1 261 ? 5.30524   -10.67419 -0.52897  1.000 28.59145  ? 253 GLU A HB2  1 
ATOM   3848 H  HB3  . GLU A 1 261 ? 4.71550   -11.47498 0.71053   1.000 28.59145  ? 253 GLU A HB3  1 
ATOM   3849 H  HG2  . GLU A 1 261 ? 3.00439   -9.95684  0.92090   1.000 35.47951  ? 253 GLU A HG2  1 
ATOM   3850 H  HG3  . GLU A 1 261 ? 3.62285   -9.06243  -0.23796  1.000 35.47951  ? 253 GLU A HG3  1 
ATOM   3851 N  N    . HIS A 1 262 ? 4.68691   -10.38221 3.40207   1.000 17.36444  ? 254 HIS A N    1 
ATOM   3852 C  CA   . HIS A 1 262 ? 3.88346   -10.10508 4.58536   1.000 17.31281  ? 254 HIS A CA   1 
ATOM   3853 C  C    . HIS A 1 262 ? 4.51665   -8.98616  5.41829   1.000 21.00091  ? 254 HIS A C    1 
ATOM   3854 O  O    . HIS A 1 262 ? 3.83508   -8.04471  5.84782   1.000 17.17464  ? 254 HIS A O    1 
ATOM   3855 C  CB   . HIS A 1 262 ? 3.71681   -11.39628 5.40705   1.000 26.83860  ? 254 HIS A CB   1 
ATOM   3856 C  CG   . HIS A 1 262 ? 2.81666   -11.25356 6.58887   1.000 21.79708  ? 254 HIS A CG   1 
ATOM   3857 N  ND1  . HIS A 1 262 ? 3.22958   -11.55610 7.86630   1.000 28.67879  ? 254 HIS A ND1  1 
ATOM   3858 C  CD2  . HIS A 1 262 ? 1.52985   -10.84589 6.69300   1.000 17.06279  ? 254 HIS A CD2  1 
ATOM   3859 C  CE1  . HIS A 1 262 ? 2.24096   -11.32852 8.71006   1.000 21.04173  ? 254 HIS A CE1  1 
ATOM   3860 N  NE2  . HIS A 1 262 ? 1.19518   -10.90152 8.02440   1.000 25.07699  ? 254 HIS A NE2  1 
ATOM   3861 H  H    . HIS A 1 262 ? 4.93078   -11.20291 3.32101   1.000 20.81413  ? 254 HIS A H    1 
ATOM   3862 H  HA   . HIS A 1 262 ? 2.99852   -9.80946  4.32004   1.000 20.75219  ? 254 HIS A HA   1 
ATOM   3863 H  HB2  . HIS A 1 262 ? 3.34338   -12.08359 4.83341   1.000 32.18313  ? 254 HIS A HB2  1 
ATOM   3864 H  HB3  . HIS A 1 262 ? 4.58809   -11.67251 5.73181   1.000 32.18313  ? 254 HIS A HB3  1 
ATOM   3865 H  HD2  . HIS A 1 262 ? 0.97665   -10.57857 5.99485   1.000 20.45216  ? 254 HIS A HD2  1 
ATOM   3866 H  HE1  . HIS A 1 262 ? 2.27451   -11.44839 9.63169   1.000 25.22688  ? 254 HIS A HE1  1 
ATOM   3867 N  N    . ASP A 1 263 ? 5.82772   -9.09702  5.66937   1.000 12.86249  ? 255 ASP A N    1 
ATOM   3868 C  CA   . ASP A 1 263 ? 6.47788   -8.10607  6.51993   1.000 16.29931  ? 255 ASP A CA   1 
ATOM   3869 C  C    . ASP A 1 263 ? 6.64100   -6.76168  5.82442   1.000 13.43868  ? 255 ASP A C    1 
ATOM   3870 O  O    . ASP A 1 263 ? 6.53173   -5.71937  6.47666   1.000 21.01197  ? 255 ASP A O    1 
ATOM   3871 C  CB   . ASP A 1 263 ? 7.82837   -8.61770  6.98967   1.000 15.19231  ? 255 ASP A CB   1 
ATOM   3872 C  CG   . ASP A 1 263 ? 7.68898   -9.63646  8.10627   1.000 23.21472  ? 255 ASP A CG   1 
ATOM   3873 O  OD1  . ASP A 1 263 ? 6.97772   -9.31961  9.08456   1.000 18.69853  ? 255 ASP A OD1  1 
ATOM   3874 O  OD2  . ASP A 1 263 ? 8.26595   -10.74624 7.99434   1.000 21.12166  ? 255 ASP A OD2  1 
ATOM   3875 H  H    . ASP A 1 263 ? 6.34172   -9.71697  5.36761   1.000 15.41180  ? 255 ASP A H    1 
ATOM   3876 H  HA   . ASP A 1 263 ? 5.91626   -7.96888  7.29882   1.000 19.53598  ? 255 ASP A HA   1 
ATOM   3877 H  HB2  . ASP A 1 263 ? 8.28550   -9.04188  6.24670   1.000 18.20759  ? 255 ASP A HB2  1 
ATOM   3878 H  HB3  . ASP A 1 263 ? 8.35438   -7.87332  7.32147   1.000 18.20759  ? 255 ASP A HB3  1 
ATOM   3879 N  N    . LEU A 1 264 ? 6.90749   -6.74340  4.52178   1.000 16.80574  ? 256 LEU A N    1 
ATOM   3880 C  CA   . LEU A 1 264 ? 7.05371   -5.46133  3.83700   1.000 21.23997  ? 256 LEU A CA   1 
ATOM   3881 C  C    . LEU A 1 264 ? 5.72812   -4.71866  3.75684   1.000 16.34949  ? 256 LEU A C    1 
ATOM   3882 O  O    . LEU A 1 264 ? 5.70122   -3.48308  3.79190   1.000 15.19388  ? 256 LEU A O    1 
ATOM   3883 C  CB   . LEU A 1 264 ? 7.62063   -5.67210  2.43410   1.000 19.75411  ? 256 LEU A CB   1 
ATOM   3884 C  CG   . LEU A 1 264 ? 9.07469   -6.14652  2.37645   1.000 19.18348  ? 256 LEU A CG   1 
ATOM   3885 C  CD1  . LEU A 1 264 ? 9.35351   -6.75662  1.00326   1.000 21.86173  ? 256 LEU A CD1  1 
ATOM   3886 C  CD2  . LEU A 1 264 ? 10.04707  -5.00618  2.67680   1.000 10.20741  ? 256 LEU A CD2  1 
ATOM   3887 H  H    . LEU A 1 264 ? 7.00589   -7.43797  4.02430   1.000 20.14370  ? 256 LEU A H    1 
ATOM   3888 H  HA   . LEU A 1 264 ? 7.68107   -4.91421  4.33498   1.000 25.46477  ? 256 LEU A HA   1 
ATOM   3889 H  HB2  . LEU A 1 264 ? 7.08005   -6.34028  1.98443   1.000 23.68174  ? 256 LEU A HB2  1 
ATOM   3890 H  HB3  . LEU A 1 264 ? 7.57188   -4.82942  1.95618   1.000 23.68174  ? 256 LEU A HB3  1 
ATOM   3891 H  HG   . LEU A 1 264 ? 9.21919   -6.82272  3.05673   1.000 22.99698  ? 256 LEU A HG   1 
ATOM   3892 H  HD11 . LEU A 1 264 ? 10.27326  -7.06349  0.97489   1.000 26.21088  ? 256 LEU A HD11 1 
ATOM   3893 H  HD12 . LEU A 1 264 ? 8.75109   -7.50350  0.86131   1.000 26.21088  ? 256 LEU A HD12 1 
ATOM   3894 H  HD13 . LEU A 1 264 ? 9.20905   -6.08108  0.32233   1.000 26.21088  ? 256 LEU A HD13 1 
ATOM   3895 H  HD21 . LEU A 1 264 ? 10.95419  -5.34838  2.64632   1.000 12.22571  ? 256 LEU A HD21 1 
ATOM   3896 H  HD22 . LEU A 1 264 ? 9.93342   -4.31049  2.01047   1.000 12.22571  ? 256 LEU A HD22 1 
ATOM   3897 H  HD23 . LEU A 1 264 ? 9.85634   -4.65282  3.55978   1.000 12.22571  ? 256 LEU A HD23 1 
ATOM   3898 N  N    . LYS A 1 265 ? 4.62404   -5.45008  3.63698   1.000 15.51538  ? 257 LYS A N    1 
ATOM   3899 C  CA   . LYS A 1 265 ? 3.31556   -4.81587  3.71184   1.000 16.70762  ? 257 LYS A CA   1 
ATOM   3900 C  C    . LYS A 1 265 ? 3.14122   -4.08529  5.03469   1.000 19.07169  ? 257 LYS A C    1 
ATOM   3901 O  O    . LYS A 1 265 ? 2.57698   -2.98570  5.07718   1.000 18.81400  ? 257 LYS A O    1 
ATOM   3902 C  CB   . LYS A 1 265 ? 2.22018   -5.86589  3.52900   1.000 20.02143  ? 257 LYS A CB   1 
ATOM   3903 C  CG   . LYS A 1 265 ? 2.05811   -6.36523  2.07634   1.000 24.49323  ? 257 LYS A CG   1 
ATOM   3904 C  CD   . LYS A 1 265 ? 1.34466   -7.71097  2.02887   1.000 28.78081  ? 257 LYS A CD   1 
ATOM   3905 C  CE   . LYS A 1 265 ? -0.03470  -7.64890  2.61983   1.000 27.36851  ? 257 LYS A CE   1 
ATOM   3906 N  NZ   . LYS A 1 265 ? -0.66323  -9.03367  2.69646   1.000 32.01013  ? 257 LYS A NZ   1 
ATOM   3907 H  H    . LYS A 1 265 ? 4.60598   -6.30102  3.51379   1.000 18.59527  ? 257 LYS A H    1 
ATOM   3908 H  HA   . LYS A 1 265 ? 3.23388   -4.16714  2.99533   1.000 20.02596  ? 257 LYS A HA   1 
ATOM   3909 H  HB2  . LYS A 1 265 ? 2.43146   -6.63403  4.08238   1.000 24.00253  ? 257 LYS A HB2  1 
ATOM   3910 H  HB3  . LYS A 1 265 ? 1.37317   -5.48159  3.80431   1.000 24.00253  ? 257 LYS A HB3  1 
ATOM   3911 H  HG2  . LYS A 1 265 ? 1.53392   -5.72357  1.57196   1.000 29.36869  ? 257 LYS A HG2  1 
ATOM   3912 H  HG3  . LYS A 1 265 ? 2.93371   -6.46921  1.67210   1.000 29.36869  ? 257 LYS A HG3  1 
ATOM   3913 H  HD2  . LYS A 1 265 ? 1.26380   -7.99543  1.10505   1.000 34.51379  ? 257 LYS A HD2  1 
ATOM   3914 H  HD3  . LYS A 1 265 ? 1.85889   -8.36126  2.53245   1.000 34.51379  ? 257 LYS A HD3  1 
ATOM   3915 H  HE2  . LYS A 1 265 ? 0.01533   -7.28504  3.51761   1.000 32.81902  ? 257 LYS A HE2  1 
ATOM   3916 H  HE3  . LYS A 1 265 ? -0.59808  -7.08701  2.06505   1.000 32.81902  ? 257 LYS A HE3  1 
ATOM   3917 H  HZ1  . LYS A 1 265 ? -1.26259  -9.13234  2.04598   1.000 38.38897  ? 257 LYS A HZ1  1 
ATOM   3918 H  HZ2  . LYS A 1 265 ? -0.03540  -9.65825  2.60790   1.000 38.38897  ? 257 LYS A HZ2  1 
ATOM   3919 H  HZ3  . LYS A 1 265 ? -1.06865  -9.14093  3.48147   1.000 38.38897  ? 257 LYS A HZ3  1 
ATOM   3920 N  N    . GLY A 1 266 ? 3.61745   -4.67844  6.12831   1.000 12.01492  ? 258 GLY A N    1 
ATOM   3921 C  CA   . GLY A 1 266 ? 3.42758   -4.05291  7.42180   1.000 15.56534  ? 258 GLY A CA   1 
ATOM   3922 C  C    . GLY A 1 266 ? 4.32804   -2.85119  7.59538   1.000 20.81254  ? 258 GLY A C    1 
ATOM   3923 O  O    . GLY A 1 266 ? 3.92803   -1.84324  8.18629   1.000 19.47025  ? 258 GLY A O    1 
ATOM   3924 H  H    . GLY A 1 266 ? 4.04329   -5.42546  6.14330   1.000 14.39472  ? 258 GLY A H    1 
ATOM   3925 H  HA2  . GLY A 1 266 ? 2.50582   -3.76398  7.50998   1.000 18.65522  ? 258 GLY A HA2  1 
ATOM   3926 H  HA3  . GLY A 1 266 ? 3.62658   -4.69240  8.12348   1.000 18.65522  ? 258 GLY A HA3  1 
ATOM   3927 N  N    . LEU A 1 267 ? 5.55206   -2.93134  7.06898   1.000 17.76328  ? 259 LEU A N    1 
ATOM   3928 C  CA   . LEU A 1 267 ? 6.45992   -1.79799  7.18375   1.000 23.04887  ? 259 LEU A CA   1 
ATOM   3929 C  C    . LEU A 1 267 ? 5.97104   -0.62079  6.34593   1.000 20.97400  ? 259 LEU A C    1 
ATOM   3930 O  O    . LEU A 1 267 ? 6.11304   0.54054   6.74797   1.000 15.53924  ? 259 LEU A O    1 
ATOM   3931 C  CB   . LEU A 1 267 ? 7.86480   -2.21629  6.76536   1.000 19.80140  ? 259 LEU A CB   1 
ATOM   3932 C  CG   . LEU A 1 267 ? 8.93450   -1.14021  6.91570   1.000 27.05146  ? 259 LEU A CG   1 
ATOM   3933 C  CD1  . LEU A 1 267 ? 9.22325   -0.86044  8.38014   1.000 22.51552  ? 259 LEU A CD1  1 
ATOM   3934 C  CD2  . LEU A 1 267 ? 10.21234  -1.55703  6.17694   1.000 19.46337  ? 259 LEU A CD2  1 
ATOM   3935 H  H    . LEU A 1 267 ? 5.86995   -3.61318  6.65229   1.000 21.29275  ? 259 LEU A H    1 
ATOM   3936 H  HA   . LEU A 1 267 ? 6.49800   -1.51102  8.10954   1.000 27.63545  ? 259 LEU A HA   1 
ATOM   3937 H  HB2  . LEU A 1 267 ? 8.13386   -2.97178  7.31102   1.000 23.73849  ? 259 LEU A HB2  1 
ATOM   3938 H  HB3  . LEU A 1 267 ? 7.84116   -2.47397  5.83051   1.000 23.73849  ? 259 LEU A HB3  1 
ATOM   3939 H  HG   . LEU A 1 267 ? 8.61041   -0.31551  6.52107   1.000 32.43856  ? 259 LEU A HG   1 
ATOM   3940 H  HD11 . LEU A 1 267 ? 9.92025   -0.18867  8.44186   1.000 26.99544  ? 259 LEU A HD11 1 
ATOM   3941 H  HD12 . LEU A 1 267 ? 8.41365   -0.53714  8.80549   1.000 26.99544  ? 259 LEU A HD12 1 
ATOM   3942 H  HD13 . LEU A 1 267 ? 9.51598   -1.68098  8.80666   1.000 26.99544  ? 259 LEU A HD13 1 
ATOM   3943 H  HD21 . LEU A 1 267 ? 10.88320  -0.86590  6.29175   1.000 23.33285  ? 259 LEU A HD21 1 
ATOM   3944 H  HD22 . LEU A 1 267 ? 10.53286  -2.39401  6.54793   1.000 23.33285  ? 259 LEU A HD22 1 
ATOM   3945 H  HD23 . LEU A 1 267 ? 10.01030  -1.66866  5.23480   1.000 23.33285  ? 259 LEU A HD23 1 
ATOM   3946 N  N    . ALA A 1 268 ? 5.40841   -0.90018  5.17026   1.000 17.14781  ? 260 ALA A N    1 
ATOM   3947 C  CA   . ALA A 1 268 ? 4.84208   0.16560   4.35261   1.000 19.80961  ? 260 ALA A CA   1 
ATOM   3948 C  C    . ALA A 1 268 ? 3.67813   0.83345   5.07083   1.000 17.26907  ? 260 ALA A C    1 
ATOM   3949 O  O    . ALA A 1 268 ? 3.56273   2.06111   5.07041   1.000 20.06539  ? 260 ALA A O    1 
ATOM   3950 C  CB   . ALA A 1 268 ? 4.39415   -0.38645  2.99709   1.000 18.71509  ? 260 ALA A CB   1 
ATOM   3951 H  H    . ALA A 1 268 ? 5.34334   -1.68707  4.82942   1.000 20.55419  ? 260 ALA A H    1 
ATOM   3952 H  HA   . ALA A 1 268 ? 5.52498   0.83424   4.18688   1.000 23.74835  ? 260 ALA A HA   1 
ATOM   3953 H  HB1  . ALA A 1 268 ? 4.02040   0.33664   2.46951   1.000 22.43492  ? 260 ALA A HB1  1 
ATOM   3954 H  HB2  . ALA A 1 268 ? 5.16176   -0.76592  2.54137   1.000 22.43492  ? 260 ALA A HB2  1 
ATOM   3955 H  HB3  . ALA A 1 268 ? 3.72303   -1.07179  3.14137   1.000 22.43492  ? 260 ALA A HB3  1 
ATOM   3956 N  N    . VAL A 1 269 ? 2.80484   0.04060   5.69701   1.000 17.19506  ? 261 VAL A N    1 
ATOM   3957 C  CA   . VAL A 1 269 ? 1.72615   0.62103   6.49223   1.000 20.35105  ? 261 VAL A CA   1 
ATOM   3958 C  C    . VAL A 1 269 ? 2.30215   1.52236   7.57180   1.000 21.76433  ? 261 VAL A C    1 
ATOM   3959 O  O    . VAL A 1 269 ? 1.78646   2.61634   7.82853   1.000 17.58014  ? 261 VAL A O    1 
ATOM   3960 C  CB   . VAL A 1 269 ? 0.84979   -0.49107  7.09913   1.000 18.51256  ? 261 VAL A CB   1 
ATOM   3961 C  CG1  . VAL A 1 269 ? -0.02825  0.05794   8.21073   1.000 21.13324  ? 261 VAL A CG1  1 
ATOM   3962 C  CG2  . VAL A 1 269 ? 0.00488   -1.15943  6.01901   1.000 21.29609  ? 261 VAL A CG2  1 
ATOM   3963 H  H    . VAL A 1 269 ? 2.81589   -0.81910  5.67694   1.000 20.61088  ? 261 VAL A H    1 
ATOM   3964 H  HA   . VAL A 1 269 ? 1.16676   1.15916   5.91050   1.000 24.39808  ? 261 VAL A HA   1 
ATOM   3965 H  HB   . VAL A 1 269 ? 1.42972   -1.16549  7.48608   1.000 22.19188  ? 261 VAL A HB   1 
ATOM   3966 H  HG11 . VAL A 1 269 ? -0.65772  -0.62771  8.48377   1.000 25.33670  ? 261 VAL A HG11 1 
ATOM   3967 H  HG12 . VAL A 1 269 ? 0.53263   0.30975   8.96100   1.000 25.33670  ? 261 VAL A HG12 1 
ATOM   3968 H  HG13 . VAL A 1 269 ? -0.50722  0.83417   7.88063   1.000 25.33670  ? 261 VAL A HG13 1 
ATOM   3969 H  HG21 . VAL A 1 269 ? -0.54222  -1.84852  6.42734   1.000 25.53212  ? 261 VAL A HG21 1 
ATOM   3970 H  HG22 . VAL A 1 269 ? -0.56139  -0.49111  5.60238   1.000 25.53212  ? 261 VAL A HG22 1 
ATOM   3971 H  HG23 . VAL A 1 269 ? 0.59353   -1.55375  5.35651   1.000 25.53212  ? 261 VAL A HG23 1 
ATOM   3972 N  N    . SER A 1 270 ? 3.39022   1.08017   8.20779   1.000 13.15804  ? 262 SER A N    1 
ATOM   3973 C  CA   . SER A 1 270 ? 3.98036   1.82990   9.30934   1.000 18.81326  ? 262 SER A CA   1 
ATOM   3974 C  C    . SER A 1 270 ? 4.65163   3.11323   8.83770   1.000 21.29662  ? 262 SER A C    1 
ATOM   3975 O  O    . SER A 1 270 ? 4.67729   4.09923   9.58428   1.000 22.37058  ? 262 SER A O    1 
ATOM   3976 C  CB   . SER A 1 270 ? 4.98401   0.94875   10.04909  1.000 21.24310  ? 262 SER A CB   1 
ATOM   3977 O  OG   . SER A 1 270 ? 5.59505   1.67284   11.09621  1.000 29.02076  ? 262 SER A OG   1 
ATOM   3978 H  H    . SER A 1 270 ? 3.80322   0.34982   8.01909   1.000 15.76645  ? 262 SER A H    1 
ATOM   3979 H  HA   . SER A 1 270 ? 3.27547   2.08050   9.92677   1.000 22.55272  ? 262 SER A HA   1 
ATOM   3980 H  HB2  . SER A 1 270 ? 4.52021   0.18239   10.42121  1.000 25.46853  ? 262 SER A HB2  1 
ATOM   3981 H  HB3  . SER A 1 270 ? 5.66670   0.65325   9.42659   1.000 25.46853  ? 262 SER A HB3  1 
ATOM   3982 H  HG   . SER A 1 270 ? 6.14926   1.18543   11.49730  1.000 34.80173  ? 262 SER A HG   1 
ATOM   3983 N  N    . PHE A 1 271 ? 5.22210   3.11589   7.62836   1.000 19.19108  ? 263 PHE A N    1 
ATOM   3984 C  CA   . PHE A 1 271 ? 5.74738   4.34299   7.03831   1.000 24.98608  ? 263 PHE A CA   1 
ATOM   3985 C  C    . PHE A 1 271 ? 4.66916   5.17552   6.35122   1.000 19.17242  ? 263 PHE A C    1 
ATOM   3986 O  O    . PHE A 1 271 ? 4.96735   6.27844   5.88494   1.000 19.94476  ? 263 PHE A O    1 
ATOM   3987 C  CB   . PHE A 1 271 ? 6.82555   4.03603   5.98553   1.000 24.96305  ? 263 PHE A CB   1 
ATOM   3988 C  CG   . PHE A 1 271 ? 8.10863   3.49389   6.53690   1.000 25.11154  ? 263 PHE A CG   1 
ATOM   3989 C  CD1  . PHE A 1 271 ? 8.41687   3.61062   7.87488   1.000 28.61985  ? 263 PHE A CD1  1 
ATOM   3990 C  CD2  . PHE A 1 271 ? 9.01790   2.86973   5.69551   1.000 29.69992  ? 263 PHE A CD2  1 
ATOM   3991 C  CE1  . PHE A 1 271 ? 9.61331   3.12564   8.37388   1.000 26.98604  ? 263 PHE A CE1  1 
ATOM   3992 C  CE2  . PHE A 1 271 ? 10.21592  2.36448   6.18817   1.000 32.30674  ? 263 PHE A CE2  1 
ATOM   3993 C  CZ   . PHE A 1 271 ? 10.50871  2.49313   7.53730   1.000 32.22856  ? 263 PHE A CZ   1 
ATOM   3994 H  H    . PHE A 1 271 ? 5.31515   2.41905   7.13304   1.000 23.00611  ? 263 PHE A H    1 
ATOM   3995 H  HA   . PHE A 1 271 ? 6.15143   4.85537   7.75603   1.000 29.96011  ? 263 PHE A HA   1 
ATOM   3996 H  HB2  . PHE A 1 271 ? 6.47282   3.37713   5.36720   1.000 29.93247  ? 263 PHE A HB2  1 
ATOM   3997 H  HB3  . PHE A 1 271 ? 7.03550   4.85625   5.51217   1.000 29.93247  ? 263 PHE A HB3  1 
ATOM   3998 H  HD1  . PHE A 1 271 ? 7.81262   4.02095   8.45057   1.000 34.32063  ? 263 PHE A HD1  1 
ATOM   3999 H  HD2  . PHE A 1 271 ? 8.82357   2.78812   4.78971   1.000 35.61672  ? 263 PHE A HD2  1 
ATOM   4000 H  HE1  . PHE A 1 271 ? 9.81404   3.22666   9.27632   1.000 32.36006  ? 263 PHE A HE1  1 
ATOM   4001 H  HE2  . PHE A 1 271 ? 10.81667  1.94318   5.61676   1.000 38.74490  ? 263 PHE A HE2  1 
ATOM   4002 H  HZ   . PHE A 1 271 ? 11.30556  2.15430   7.87660   1.000 38.65109  ? 263 PHE A HZ   1 
ATOM   4003 N  N    . LYS A 1 272 ? 3.43956   4.66716   6.25550   1.000 20.56477  ? 264 LYS A N    1 
ATOM   4004 C  CA   . LYS A 1 272 ? 2.38295   5.25982   5.42378   1.000 19.46533  ? 264 LYS A CA   1 
ATOM   4005 C  C    . LYS A 1 272 ? 2.83503   5.36309   3.97268   1.000 22.78555  ? 264 LYS A C    1 
ATOM   4006 O  O    . LYS A 1 272 ? 2.60794   6.36671   3.29268   1.000 17.81108  ? 264 LYS A O    1 
ATOM   4007 C  CB   . LYS A 1 272 ? 1.92948   6.62295   5.93167   1.000 22.62101  ? 264 LYS A CB   1 
ATOM   4008 C  CG   . LYS A 1 272 ? 0.52928   6.98504   5.45411   1.000 29.41773  ? 264 LYS A CG   1 
ATOM   4009 C  CD   . LYS A 1 272 ? 0.38941   8.48706   5.32261   1.000 28.58791  ? 264 LYS A CD   1 
ATOM   4010 C  CE   . LYS A 1 272 ? -0.10650  9.09003   6.61581   1.000 39.17463  ? 264 LYS A CE   1 
ATOM   4011 N  NZ   . LYS A 1 272 ? -1.09489  10.20393  6.40082   1.000 48.98823  ? 264 LYS A NZ   1 
ATOM   4012 H  H    . LYS A 1 272 ? 3.18295   3.96035   6.67284   1.000 24.65454  ? 264 LYS A H    1 
ATOM   4013 H  HA   . LYS A 1 272 ? 1.61419   4.67010   5.47002   1.000 23.33521  ? 264 LYS A HA   1 
ATOM   4014 H  HB2  . LYS A 1 272 ? 1.92458   6.61413   6.90161   1.000 27.12202  ? 264 LYS A HB2  1 
ATOM   4015 H  HB3  . LYS A 1 272 ? 2.54312   7.30144   5.60917   1.000 27.12202  ? 264 LYS A HB3  1 
ATOM   4016 H  HG2  . LYS A 1 272 ? 0.36654   6.58183   4.58702   1.000 35.27809  ? 264 LYS A HG2  1 
ATOM   4017 H  HG3  . LYS A 1 272 ? -0.12567  6.66806   6.09557   1.000 35.27809  ? 264 LYS A HG3  1 
ATOM   4018 H  HD2  . LYS A 1 272 ? 1.25247   8.87630   5.11160   1.000 34.28230  ? 264 LYS A HD2  1 
ATOM   4019 H  HD3  . LYS A 1 272 ? -0.24809  8.69365   4.62132   1.000 34.28230  ? 264 LYS A HD3  1 
ATOM   4020 H  HE2  . LYS A 1 272 ? -0.54286  8.39974   7.13926   1.000 46.98636  ? 264 LYS A HE2  1 
ATOM   4021 H  HE3  . LYS A 1 272 ? 0.64872   9.45067   7.10620   1.000 46.98636  ? 264 LYS A HE3  1 
ATOM   4022 H  HZ1  . LYS A 1 272 ? -1.36437  10.52734  7.18497   1.000 58.76269  ? 264 LYS A HZ1  1 
ATOM   4023 H  HZ2  . LYS A 1 272 ? -0.71733  10.85970  5.93229   1.000 58.76269  ? 264 LYS A HZ2  1 
ATOM   4024 H  HZ3  . LYS A 1 272 ? -1.80286  9.90081   5.95471   1.000 58.76269  ? 264 LYS A HZ3  1 
ATOM   4025 N  N    . GLY A 1 273 ? 3.53399   4.33234   3.50879   1.000 22.97580  ? 265 GLY A N    1 
ATOM   4026 C  CA   . GLY A 1 273 ? 3.84460   4.17525   2.10810   1.000 26.13141  ? 265 GLY A CA   1 
ATOM   4027 C  C    . GLY A 1 273 ? 3.10987   2.98551   1.49388   1.000 21.88604  ? 265 GLY A C    1 
ATOM   4028 O  O    . GLY A 1 273 ? 2.32482   2.28923   2.13222   1.000 21.23010  ? 265 GLY A O    1 
ATOM   4029 H  H    . GLY A 1 273 ? 3.84282   3.70057   4.00386   1.000 27.54777  ? 265 GLY A H    1 
ATOM   4030 H  HA2  . GLY A 1 273 ? 3.58711   4.97776   1.62792   1.000 31.33450  ? 265 GLY A HA2  1 
ATOM   4031 H  HA3  . GLY A 1 273 ? 4.79873   4.03630   2.00219   1.000 31.33450  ? 265 GLY A HA3  1 
ATOM   4032 N  N    . LYS A 1 274 ? 3.40100   2.74304   0.22191   1.000 21.21039  ? 266 LYS A N    1 
ATOM   4033 C  CA   A LYS A 1 274 ? 2.76740   1.66647   -0.52804  0.505 25.49303  ? 266 LYS A CA   1 
ATOM   4034 C  CA   B LYS A 1 274 ? 2.76719   1.67734   -0.54798  0.495 25.24497  ? 266 LYS A CA   1 
ATOM   4035 C  C    . LYS A 1 274 ? 3.83809   0.70105   -1.01194  1.000 23.14885  ? 266 LYS A C    1 
ATOM   4036 O  O    . LYS A 1 274 ? 4.83773   1.12070   -1.60435  1.000 20.02849  ? 266 LYS A O    1 
ATOM   4037 C  CB   A LYS A 1 274 ? 1.96674   2.21750   -1.71407  0.505 27.53671  ? 266 LYS A CB   1 
ATOM   4038 C  CB   B LYS A 1 274 ? 2.02665   2.25781   -1.75903  0.495 25.17519  ? 266 LYS A CB   1 
ATOM   4039 C  CG   A LYS A 1 274 ? 0.46310   2.09877   -1.54170  0.505 30.88871  ? 266 LYS A CG   1 
ATOM   4040 C  CG   B LYS A 1 274 ? 0.91437   1.40186   -2.32644  0.495 24.77179  ? 266 LYS A CG   1 
ATOM   4041 C  CD   A LYS A 1 274 ? -0.28536  2.30453   -2.85954  0.505 28.56805  ? 266 LYS A CD   1 
ATOM   4042 C  CD   B LYS A 1 274 ? 0.35100   1.99520   -3.63036  0.495 26.25495  ? 266 LYS A CD   1 
ATOM   4043 C  CE   A LYS A 1 274 ? -0.36906  1.01342   -3.66812  0.505 27.11332  ? 266 LYS A CE   1 
ATOM   4044 C  CE   B LYS A 1 274 ? 0.23811   3.52447   -3.58990  0.495 28.27346  ? 266 LYS A CE   1 
ATOM   4045 N  NZ   A LYS A 1 274 ? -1.35044  0.04550   -3.09706  0.505 29.57363  ? 266 LYS A NZ   1 
ATOM   4046 N  NZ   B LYS A 1 274 ? -0.72006  4.02277   -2.55253  0.495 29.53553  ? 266 LYS A NZ   1 
ATOM   4047 H  H    A LYS A 1 274 ? 3.97147   3.19602   -0.23521  0.505 25.42928  ? 266 LYS A H    1 
ATOM   4048 H  H    B LYS A 1 274 ? 3.97760   3.19386   -0.22963  0.495 25.42928  ? 266 LYS A H    1 
ATOM   4049 H  HA   A LYS A 1 274 ? 2.15687   1.18103   0.04859   0.505 30.56845  ? 266 LYS A HA   1 
ATOM   4050 H  HA   B LYS A 1 274 ? 2.13165   1.19855   0.00677   0.495 30.27077  ? 266 LYS A HA   1 
ATOM   4051 H  HB2  A LYS A 1 274 ? 2.17930   3.15746   -1.82448  0.505 33.02086  ? 266 LYS A HB2  1 
ATOM   4052 H  HB2  B LYS A 1 274 ? 1.63199   3.10406   -1.49636  0.495 30.18703  ? 266 LYS A HB2  1 
ATOM   4053 H  HB3  A LYS A 1 274 ? 2.21346   1.72553   -2.51282  0.505 33.02086  ? 266 LYS A HB3  1 
ATOM   4054 H  HB3  B LYS A 1 274 ? 2.67134   2.39885   -2.46993  0.495 30.18703  ? 266 LYS A HB3  1 
ATOM   4055 H  HG2  A LYS A 1 274 ? 0.24923   1.21359   -1.20762  0.505 37.04326  ? 266 LYS A HG2  1 
ATOM   4056 H  HG2  B LYS A 1 274 ? 1.25804   0.51545   -2.51899  0.495 29.70296  ? 266 LYS A HG2  1 
ATOM   4057 H  HG3  A LYS A 1 274 ? 0.15985   2.77272   -0.91343  0.505 37.04326  ? 266 LYS A HG3  1 
ATOM   4058 H  HG3  B LYS A 1 274 ? 0.19240   1.34482   -1.68116  0.495 29.70296  ? 266 LYS A HG3  1 
ATOM   4059 H  HD2  A LYS A 1 274 ? -1.18841  2.60478   -2.67182  0.505 34.25847  ? 266 LYS A HD2  1 
ATOM   4060 H  HD2  B LYS A 1 274 ? 0.93825   1.75808   -4.36507  0.495 31.48275  ? 266 LYS A HD2  1 
ATOM   4061 H  HD3  A LYS A 1 274 ? 0.18059   2.96750   -3.39271  0.505 34.25847  ? 266 LYS A HD3  1 
ATOM   4062 H  HD3  B LYS A 1 274 ? -0.53589  1.63391   -3.78464  0.495 31.48275  ? 266 LYS A HD3  1 
ATOM   4063 H  HE2  A LYS A 1 274 ? -0.64573  1.22347   -4.57379  0.505 32.51279  ? 266 LYS A HE2  1 
ATOM   4064 H  HE2  B LYS A 1 274 ? 1.11097   3.89848   -3.39208  0.495 33.90496  ? 266 LYS A HE2  1 
ATOM   4065 H  HE3  A LYS A 1 274 ? 0.50256   0.58787   -3.67776  0.505 32.51279  ? 266 LYS A HE3  1 
ATOM   4066 H  HE3  B LYS A 1 274 ? -0.06964  3.83943   -4.45419  0.495 33.90496  ? 266 LYS A HE3  1 
ATOM   4067 H  HZ1  A LYS A 1 274 ? -1.57354  -0.55946  -3.71053  0.505 35.46517  ? 266 LYS A HZ1  1 
ATOM   4068 H  HZ1  B LYS A 1 274 ? -0.64777  4.90604   -2.47063  0.495 35.41944  ? 266 LYS A HZ1  1 
ATOM   4069 H  HZ2  A LYS A 1 274 ? -0.99403  -0.37165  -2.39630  0.505 35.46517  ? 266 LYS A HZ2  1 
ATOM   4070 H  HZ2  B LYS A 1 274 ? -1.55464  3.82182   -2.78745  0.495 35.41944  ? 266 LYS A HZ2  1 
ATOM   4071 H  HZ3  A LYS A 1 274 ? -2.08441  0.47517   -2.83481  0.505 35.46517  ? 266 LYS A HZ3  1 
ATOM   4072 H  HZ3  B LYS A 1 274 ? -0.54205  3.64432   -1.76691  0.495 35.41944  ? 266 LYS A HZ3  1 
ATOM   4073 N  N    . TYR A 1 275 ? 3.63143   -0.58878  -0.74836  1.000 15.84614  ? 267 TYR A N    1 
ATOM   4074 C  CA   . TYR A 1 275 ? 4.55461   -1.62506  -1.18979  1.000 19.30401  ? 267 TYR A CA   1 
ATOM   4075 C  C    . TYR A 1 275 ? 4.06396   -2.18323  -2.51981  1.000 18.47455  ? 267 TYR A C    1 
ATOM   4076 O  O    . TYR A 1 275 ? 2.93562   -2.68143  -2.61209  1.000 22.37407  ? 267 TYR A O    1 
ATOM   4077 C  CB   . TYR A 1 275 ? 4.67322   -2.73858  -0.15017  1.000 19.14422  ? 267 TYR A CB   1 
ATOM   4078 C  CG   . TYR A 1 275 ? 5.43900   -3.95119  -0.65279  1.000 20.42823  ? 267 TYR A CG   1 
ATOM   4079 C  CD1  . TYR A 1 275 ? 6.70801   -3.82161  -1.18908  1.000 18.20538  ? 267 TYR A CD1  1 
ATOM   4080 C  CD2  . TYR A 1 275 ? 4.89116   -5.22195  -0.59230  1.000 18.45170  ? 267 TYR A CD2  1 
ATOM   4081 C  CE1  . TYR A 1 275 ? 7.40639   -4.92455  -1.64846  1.000 17.30325  ? 267 TYR A CE1  1 
ATOM   4082 C  CE2  . TYR A 1 275 ? 5.58293   -6.31775  -1.04198  1.000 15.46194  ? 267 TYR A CE2  1 
ATOM   4083 C  CZ   . TYR A 1 275 ? 6.83056   -6.16237  -1.57912  1.000 19.73380  ? 267 TYR A CZ   1 
ATOM   4084 O  OH   . TYR A 1 275 ? 7.52347   -7.25668  -2.02908  1.000 26.55178  ? 267 TYR A OH   1 
ATOM   4085 H  H    . TYR A 1 275 ? 2.95507   -0.88906  -0.31023  1.000 18.99217  ? 267 TYR A H    1 
ATOM   4086 H  HA   . TYR A 1 275 ? 5.43630   -1.24010  -1.31360  1.000 23.14163  ? 267 TYR A HA   1 
ATOM   4087 H  HB2  . TYR A 1 275 ? 5.13899   -2.39327  0.62747   1.000 22.94988  ? 267 TYR A HB2  1 
ATOM   4088 H  HB3  . TYR A 1 275 ? 3.78259   -3.03092  0.09926   1.000 22.94988  ? 267 TYR A HB3  1 
ATOM   4089 H  HD1  . TYR A 1 275 ? 7.09820   -2.97906  -1.24170  1.000 21.82326  ? 267 TYR A HD1  1 
ATOM   4090 H  HD2  . TYR A 1 275 ? 4.03784   -5.33438  -0.24001  1.000 22.11885  ? 267 TYR A HD2  1 
ATOM   4091 H  HE1  . TYR A 1 275 ? 8.26087   -4.82437  -2.00161  1.000 20.74071  ? 267 TYR A HE1  1 
ATOM   4092 H  HE2  . TYR A 1 275 ? 5.20395   -7.16488  -0.98160  1.000 18.53114  ? 267 TYR A HE2  1 
ATOM   4093 H  HH   . TYR A 1 275 ? 7.11033   -7.96031  -1.82954  1.000 31.83894  ? 267 TYR A HH   1 
ATOM   4094 N  N    . LEU A 1 276 ? 4.91489   -2.11191  -3.53952  1.000 19.76897  ? 268 LEU A N    1 
ATOM   4095 C  CA   . LEU A 1 276 ? 4.62292   -2.63848  -4.87070  1.000 20.50714  ? 268 LEU A CA   1 
ATOM   4096 C  C    . LEU A 1 276 ? 5.42182   -3.92511  -5.04956  1.000 20.51567  ? 268 LEU A C    1 
ATOM   4097 O  O    . LEU A 1 276 ? 6.63793   -3.89546  -5.25688  1.000 24.04019  ? 268 LEU A O    1 
ATOM   4098 C  CB   . LEU A 1 276 ? 4.96538   -1.61168  -5.94299  1.000 21.46077  ? 268 LEU A CB   1 
ATOM   4099 C  CG   . LEU A 1 276 ? 4.18189   -0.30270  -5.85299  1.000 20.92279  ? 268 LEU A CG   1 
ATOM   4100 C  CD1  . LEU A 1 276 ? 4.68049   0.71136   -6.88476  1.000 24.14763  ? 268 LEU A CD1  1 
ATOM   4101 C  CD2  . LEU A 1 276 ? 2.69931   -0.55892  -6.02423  1.000 25.67304  ? 268 LEU A CD2  1 
ATOM   4102 H  H    . LEU A 1 276 ? 5.69348   -1.75107  -3.48293  1.000 23.69957  ? 268 LEU A H    1 
ATOM   4103 H  HA   . LEU A 1 276 ? 3.67877   -2.85049  -4.93800  1.000 24.58538  ? 268 LEU A HA   1 
ATOM   4104 H  HB2  . LEU A 1 276 ? 5.90768   -1.39369  -5.86926  1.000 25.72973  ? 268 LEU A HB2  1 
ATOM   4105 H  HB3  . LEU A 1 276 ? 4.78225   -2.00251  -6.81168  1.000 25.72973  ? 268 LEU A HB3  1 
ATOM   4106 H  HG   . LEU A 1 276 ? 4.32233   0.08310   -4.97416  1.000 25.08416  ? 268 LEU A HG   1 
ATOM   4107 H  HD11 . LEU A 1 276 ? 4.15535   1.52337   -6.80882  1.000 28.95397  ? 268 LEU A HD11 1 
ATOM   4108 H  HD12 . LEU A 1 276 ? 5.61516   0.90450   -6.71161  1.000 28.95397  ? 268 LEU A HD12 1 
ATOM   4109 H  HD13 . LEU A 1 276 ? 4.57966   0.33406   -7.77267  1.000 28.95397  ? 268 LEU A HD13 1 
ATOM   4110 H  HD21 . LEU A 1 276 ? 2.22933   0.28959   -6.01738  1.000 30.78446  ? 268 LEU A HD21 1 
ATOM   4111 H  HD22 . LEU A 1 276 ? 2.55260   -1.01149  -6.86954  1.000 30.78446  ? 268 LEU A HD22 1 
ATOM   4112 H  HD23 . LEU A 1 276 ? 2.38841   -1.11516  -5.29290  1.000 30.78446  ? 268 LEU A HD23 1 
ATOM   4113 N  N    . LYS A 1 277 ? 4.73295   -5.05934  -4.96254  1.000 23.26000  ? 269 LYS A N    1 
ATOM   4114 C  CA   . LYS A 1 277 ? 5.42829   -6.33794  -4.95950  1.000 17.26647  ? 269 LYS A CA   1 
ATOM   4115 C  C    . LYS A 1 277 ? 6.00793   -6.65201  -6.32661  1.000 21.55254  ? 269 LYS A C    1 
ATOM   4116 O  O    . LYS A 1 277 ? 7.09146   -7.24226  -6.42346  1.000 20.62282  ? 269 LYS A O    1 
ATOM   4117 C  CB   . LYS A 1 277 ? 4.47396   -7.44959  -4.52565  1.000 26.54657  ? 269 LYS A CB   1 
ATOM   4118 C  CG   . LYS A 1 277 ? 5.16424   -8.75497  -4.21500  1.000 22.27031  ? 269 LYS A CG   1 
ATOM   4119 C  CD   . LYS A 1 277 ? 4.20561   -9.94210  -4.24896  1.000 26.17080  ? 269 LYS A CD   1 
ATOM   4120 C  CE   . LYS A 1 277 ? 4.96036   -11.25267 -3.95154  1.000 28.62372  ? 269 LYS A CE   1 
ATOM   4121 N  NZ   . LYS A 1 277 ? 4.03520   -12.40338 -3.76260  1.000 36.24700  ? 269 LYS A NZ   1 
ATOM   4122 H  H    . LYS A 1 277 ? 3.87662   -5.11423  -4.90518  1.000 27.88881  ? 269 LYS A H    1 
ATOM   4123 H  HA   . LYS A 1 277 ? 6.15775   -6.29357  -4.32167  1.000 20.69658  ? 269 LYS A HA   1 
ATOM   4124 H  HB2  . LYS A 1 277 ? 4.00578   -7.16419  -3.72549  1.000 31.83270  ? 269 LYS A HB2  1 
ATOM   4125 H  HB3  . LYS A 1 277 ? 3.83941   -7.61280  -5.24091  1.000 31.83270  ? 269 LYS A HB3  1 
ATOM   4126 H  HG2  . LYS A 1 277 ? 5.86007   -8.91097  -4.87256  1.000 26.70119  ? 269 LYS A HG2  1 
ATOM   4127 H  HG3  . LYS A 1 277 ? 5.55176   -8.70622  -3.32710  1.000 26.70119  ? 269 LYS A HG3  1 
ATOM   4128 H  HD2  . LYS A 1 277 ? 3.51631   -9.82289  -3.57699  1.000 31.38177  ? 269 LYS A HD2  1 
ATOM   4129 H  HD3  . LYS A 1 277 ? 3.80298   -10.00998 -5.12883  1.000 31.38177  ? 269 LYS A HD3  1 
ATOM   4130 H  HE2  . LYS A 1 277 ? 5.54894   -11.45706 -4.69498  1.000 34.32527  ? 269 LYS A HE2  1 
ATOM   4131 H  HE3  . LYS A 1 277 ? 5.47816   -11.14458 -3.13846  1.000 34.32527  ? 269 LYS A HE3  1 
ATOM   4132 H  HZ1  . LYS A 1 277 ? 4.48236   -13.16913 -3.83858  1.000 43.47321  ? 269 LYS A HZ1  1 
ATOM   4133 H  HZ2  . LYS A 1 277 ? 3.66288   -12.36521 -2.95512  1.000 43.47321  ? 269 LYS A HZ2  1 
ATOM   4134 H  HZ3  . LYS A 1 277 ? 3.39279   -12.38173 -4.37819  1.000 43.47321  ? 269 LYS A HZ3  1 
ATOM   4135 N  N    . ASP A 1 278 ? 5.28583   -6.29821  -7.39176  1.000 16.82446  ? 270 ASP A N    1 
ATOM   4136 C  CA   . ASP A 1 278 ? 5.62986   -6.70722  -8.74774  1.000 20.35783  ? 270 ASP A CA   1 
ATOM   4137 C  C    . ASP A 1 278 ? 5.80420   -5.50074  -9.66101  1.000 21.47316  ? 270 ASP A C    1 
ATOM   4138 O  O    . ASP A 1 278 ? 5.36959   -5.50129  -10.81469 1.000 17.45082  ? 270 ASP A O    1 
ATOM   4139 C  CB   . ASP A 1 278 ? 4.58533   -7.66826  -9.31388  1.000 23.90301  ? 270 ASP A CB   1 
ATOM   4140 C  CG   . ASP A 1 278 ? 3.21367   -7.05654  -9.39578  1.000 30.17730  ? 270 ASP A CG   1 
ATOM   4141 O  OD1  . ASP A 1 278 ? 2.98786   -6.03223  -8.70285  1.000 22.58850  ? 270 ASP A OD1  1 
ATOM   4142 O  OD2  . ASP A 1 278 ? 2.36807   -7.60574  -10.15431 1.000 25.77558  ? 270 ASP A OD2  1 
ATOM   4143 H  H    . ASP A 1 278 ? 4.57825   -5.81130  -7.34880  1.000 20.16616  ? 270 ASP A H    1 
ATOM   4144 H  HA   . ASP A 1 278 ? 6.47891   -7.17511  -8.71472  1.000 24.40620  ? 270 ASP A HA   1 
ATOM   4145 H  HB2  . ASP A 1 278 ? 4.85025   -7.93100  -10.20925 1.000 28.66042  ? 270 ASP A HB2  1 
ATOM   4146 H  HB3  . ASP A 1 278 ? 4.53144   -8.44931  -8.74121  1.000 28.66042  ? 270 ASP A HB3  1 
ATOM   4147 N  N    . LEU A 1 279 ? 6.45645   -4.45433  -9.15050  1.000 14.26964  ? 271 LEU A N    1 
ATOM   4148 C  CA   . LEU A 1 279 ? 6.79389   -3.31687  -9.99404  1.000 16.20783  ? 271 LEU A CA   1 
ATOM   4149 C  C    . LEU A 1 279 ? 7.82487   -3.70400  -11.04310 1.000 13.57007  ? 271 LEU A C    1 
ATOM   4150 O  O    . LEU A 1 279 ? 7.76563   -3.21993  -12.17489 1.000 11.65376  ? 271 LEU A O    1 
ATOM   4151 C  CB   . LEU A 1 279 ? 7.30507   -2.17070  -9.12937  1.000 16.26965  ? 271 LEU A CB   1 
ATOM   4152 C  CG   . LEU A 1 279 ? 7.68069   -0.88642  -9.85372  1.000 16.40573  ? 271 LEU A CG   1 
ATOM   4153 C  CD1  . LEU A 1 279 ? 6.48993   -0.31391  -10.59997 1.000 17.37526  ? 271 LEU A CD1  1 
ATOM   4154 C  CD2  . LEU A 1 279 ? 8.23938   0.13466   -8.87575  1.000 16.32428  ? 271 LEU A CD2  1 
ATOM   4155 H  H    . LEU A 1 279 ? 6.70953   -4.38234  -8.33174  1.000 17.10038  ? 271 LEU A H    1 
ATOM   4156 H  HA   . LEU A 1 279 ? 5.99936   -3.00649  -10.45586 1.000 19.42621  ? 271 LEU A HA   1 
ATOM   4157 H  HB2  . LEU A 1 279 ? 6.61144   -1.94456  -8.49013  1.000 19.50039  ? 271 LEU A HB2  1 
ATOM   4158 H  HB3  . LEU A 1 279 ? 8.09863   -2.47719  -8.66329  1.000 19.50039  ? 271 LEU A HB3  1 
ATOM   4159 H  HG   . LEU A 1 279 ? 8.36886   -1.08907  -10.50660 1.000 19.66369  ? 271 LEU A HG   1 
ATOM   4160 H  HD11 . LEU A 1 279 ? 6.75238   0.51926   -11.02168 1.000 20.82713  ? 271 LEU A HD11 1 
ATOM   4161 H  HD12 . LEU A 1 279 ? 6.20405   -0.95014  -11.27405 1.000 20.82713  ? 271 LEU A HD12 1 
ATOM   4162 H  HD13 . LEU A 1 279 ? 5.76992   -0.15341  -9.97011  1.000 20.82713  ? 271 LEU A HD13 1 
ATOM   4163 H  HD21 . LEU A 1 279 ? 8.47810   0.93956   -9.36160  1.000 19.56595  ? 271 LEU A HD21 1 
ATOM   4164 H  HD22 . LEU A 1 279 ? 7.56308   0.33799   -8.21078  1.000 19.56595  ? 271 LEU A HD22 1 
ATOM   4165 H  HD23 . LEU A 1 279 ? 9.02512   -0.23725  -8.44541  1.000 19.56595  ? 271 LEU A HD23 1 
ATOM   4166 N  N    . PHE A 1 280 ? 8.73022   -4.61877  -10.71614 1.000 13.19167  ? 272 PHE A N    1 
ATOM   4167 C  CA   . PHE A 1 280 ? 9.73425   -5.09330  -11.65970 1.000 16.49442  ? 272 PHE A CA   1 
ATOM   4168 C  C    . PHE A 1 280 ? 9.35632   -6.45281  -12.24982 1.000 19.37198  ? 272 PHE A C    1 
ATOM   4169 O  O    . PHE A 1 280 ? 8.94911   -7.36184  -11.52781 1.000 20.36444  ? 272 PHE A O    1 
ATOM   4170 C  CB   . PHE A 1 280 ? 11.08923  -5.19732  -10.97140 1.000 15.19120  ? 272 PHE A CB   1 
ATOM   4171 C  CG   . PHE A 1 280 ? 11.77763  -3.88134  -10.80627 1.000 14.96366  ? 272 PHE A CG   1 
ATOM   4172 C  CD1  . PHE A 1 280 ? 12.44861  -3.30339  -11.86766 1.000 14.21117  ? 272 PHE A CD1  1 
ATOM   4173 C  CD2  . PHE A 1 280 ? 11.73953  -3.21100  -9.58866  1.000 14.58457  ? 272 PHE A CD2  1 
ATOM   4174 C  CE1  . PHE A 1 280 ? 13.09921  -2.07911  -11.70803 1.000 18.29950  ? 272 PHE A CE1  1 
ATOM   4175 C  CE2  . PHE A 1 280 ? 12.38186  -2.00289  -9.42192  1.000 15.57338  ? 272 PHE A CE2  1 
ATOM   4176 C  CZ   . PHE A 1 280 ? 13.05708  -1.42982  -10.48832 1.000 17.34871  ? 272 PHE A CZ   1 
ATOM   4177 H  H    . PHE A 1 280 ? 8.78373   -4.98563  -9.94015  1.000 15.80682  ? 272 PHE A H    1 
ATOM   4178 H  HA   . PHE A 1 280 ? 9.78208   -4.46456  -12.39680 1.000 19.77011  ? 272 PHE A HA   1 
ATOM   4179 H  HB2  . PHE A 1 280 ? 10.96306  -5.57925  -10.08873 1.000 18.20626  ? 272 PHE A HB2  1 
ATOM   4180 H  HB3  . PHE A 1 280 ? 11.66595  -5.76969  -11.50121 1.000 18.20626  ? 272 PHE A HB3  1 
ATOM   4181 H  HD1  . PHE A 1 280 ? 12.46658  -3.73266  -12.69247 1.000 17.03022  ? 272 PHE A HD1  1 
ATOM   4182 H  HD2  . PHE A 1 280 ? 11.27328  -3.58367  -8.87548  1.000 17.47829  ? 272 PHE A HD2  1 
ATOM   4183 H  HE1  . PHE A 1 280 ? 13.56052  -1.70053  -12.42131 1.000 21.93621  ? 272 PHE A HE1  1 
ATOM   4184 H  HE2  . PHE A 1 280 ? 12.36230  -1.57384  -8.59704  1.000 18.66487  ? 272 PHE A HE2  1 
ATOM   4185 H  HZ   . PHE A 1 280 ? 13.48151  -0.60901  -10.38327 1.000 20.79527  ? 272 PHE A HZ   1 
ATOM   4186 N  N    . LEU A 1 281 ? 9.50053   -6.58034  -13.55757 1.000 16.07101  ? 273 LEU A N    1 
ATOM   4187 C  CA   . LEU A 1 281 ? 9.29451   -7.83556  -14.25403 1.000 18.22202  ? 273 LEU A CA   1 
ATOM   4188 C  C    . LEU A 1 281 ? 10.63628  -8.35038  -14.75078 1.000 17.16863  ? 273 LEU A C    1 
ATOM   4189 O  O    . LEU A 1 281 ? 11.44640  -7.57966  -15.27635 1.000 18.74520  ? 273 LEU A O    1 
ATOM   4190 C  CB   . LEU A 1 281 ? 8.35178   -7.65252  -15.44242 1.000 22.44632  ? 273 LEU A CB   1 
ATOM   4191 C  CG   . LEU A 1 281 ? 6.95577   -7.08681  -15.18256 1.000 21.33767  ? 273 LEU A CG   1 
ATOM   4192 C  CD1  . LEU A 1 281 ? 6.15094   -6.98536  -16.48246 1.000 28.37661  ? 273 LEU A CD1  1 
ATOM   4193 C  CD2  . LEU A 1 281 ? 6.24775   -7.97183  -14.18189 1.000 22.04300  ? 273 LEU A CD2  1 
ATOM   4194 H  H    . LEU A 1 281 ? 9.72415   -5.93345  -14.07828 1.000 19.26202  ? 273 LEU A H    1 
ATOM   4195 H  HA   . LEU A 1 281 ? 8.90396   -8.48790  -13.65169 1.000 21.84324  ? 273 LEU A HA   1 
ATOM   4196 H  HB2  . LEU A 1 281 ? 8.78278   -7.04939  -16.06803 1.000 26.91240  ? 273 LEU A HB2  1 
ATOM   4197 H  HB3  . LEU A 1 281 ? 8.22595   -8.52221  -15.85316 1.000 26.91240  ? 273 LEU A HB3  1 
ATOM   4198 H  HG   . LEU A 1 281 ? 7.02710   -6.18899  -14.82238 1.000 25.58201  ? 273 LEU A HG   1 
ATOM   4199 H  HD11 . LEU A 1 281 ? 5.27317   -6.62391  -16.28303 1.000 34.02874  ? 273 LEU A HD11 1 
ATOM   4200 H  HD12 . LEU A 1 281 ? 6.61801   -6.39911  -17.09813 1.000 34.02874  ? 273 LEU A HD12 1 
ATOM   4201 H  HD13 . LEU A 1 281 ? 6.06402   -7.87034  -16.86995 1.000 34.02874  ? 273 LEU A HD13 1 
ATOM   4202 H  HD21 . LEU A 1 281 ? 5.35178   -7.62989  -14.03626 1.000 26.42841  ? 273 LEU A HD21 1 
ATOM   4203 H  HD22 . LEU A 1 281 ? 6.20409   -8.87459  -14.53407 1.000 26.42841  ? 273 LEU A HD22 1 
ATOM   4204 H  HD23 . LEU A 1 281 ? 6.74373   -7.96560  -13.34831 1.000 26.42841  ? 273 LEU A HD23 1 
ATOM   4205 N  N    . ARG A 1 282 ? 10.84734  -9.66175  -14.61555 1.000 17.94469  ? 274 ARG A N    1 
ATOM   4206 C  CA   . ARG A 1 282 ? 11.96225  -10.34839 -15.26539 1.000 15.24083  ? 274 ARG A CA   1 
ATOM   4207 C  C    . ARG A 1 282 ? 11.36711  -11.09811 -16.45839 1.000 17.40200  ? 274 ARG A C    1 
ATOM   4208 O  O    . ARG A 1 282 ? 10.84983  -12.21051 -16.32882 1.000 20.23922  ? 274 ARG A O    1 
ATOM   4209 C  CB   . ARG A 1 282 ? 12.70288  -11.27499 -14.30213 1.000 13.75417  ? 274 ARG A CB   1 
ATOM   4210 C  CG   . ARG A 1 282 ? 13.86582  -12.03108 -14.93125 1.000 14.09043  ? 274 ARG A CG   1 
ATOM   4211 C  CD   . ARG A 1 282 ? 15.12186  -11.14577 -15.05355 1.000 18.80403  ? 274 ARG A CD   1 
ATOM   4212 N  NE   . ARG A 1 282 ? 15.68643  -10.79013 -13.74728 1.000 17.27288  ? 274 ARG A NE   1 
ATOM   4213 C  CZ   . ARG A 1 282 ? 16.75054  -10.00638 -13.56342 1.000 18.86616  ? 274 ARG A CZ   1 
ATOM   4214 N  NH1  . ARG A 1 282 ? 17.38238  -9.49273  -14.59871 1.000 17.39129  ? 274 ARG A NH1  1 
ATOM   4215 N  NH2  . ARG A 1 282 ? 17.20359  -9.73754  -12.34348 1.000 18.54309  ? 274 ARG A NH2  1 
ATOM   4216 H  H    . ARG A 1 282 ? 10.34948  -10.18143 -14.14474 1.000 21.51044  ? 274 ARG A H    1 
ATOM   4217 H  HA   . ARG A 1 282 ? 12.60985  -9.69908  -15.58147 1.000 18.26580  ? 274 ARG A HA   1 
ATOM   4218 H  HB2  . ARG A 1 282 ? 13.05799  -10.74362 -13.57244 1.000 16.48182  ? 274 ARG A HB2  1 
ATOM   4219 H  HB3  . ARG A 1 282 ? 12.07603  -11.93145 -13.96005 1.000 16.48182  ? 274 ARG A HB3  1 
ATOM   4220 H  HG2  . ARG A 1 282 ? 14.08649  -12.79714 -14.37866 1.000 16.88532  ? 274 ARG A HG2  1 
ATOM   4221 H  HG3  . ARG A 1 282 ? 13.61340  -12.32513 -15.82047 1.000 16.88532  ? 274 ARG A HG3  1 
ATOM   4222 H  HD2  . ARG A 1 282 ? 15.80043  -11.62502 -15.55431 1.000 22.54164  ? 274 ARG A HD2  1 
ATOM   4223 H  HD3  . ARG A 1 282 ? 14.88782  -10.32467 -15.51391 1.000 22.54164  ? 274 ARG A HD3  1 
ATOM   4224 H  HE   . ARG A 1 282 ? 15.30287  -11.11078 -13.04751 1.000 20.70426  ? 274 ARG A HE   1 
ATOM   4225 H  HH11 . ARG A 1 282 ? 17.10939  -9.66214  -15.39644 1.000 20.84636  ? 274 ARG A HH11 1 
ATOM   4226 H  HH12 . ARG A 1 282 ? 18.06792  -8.98794  -14.47694 1.000 20.84636  ? 274 ARG A HH12 1 
ATOM   4227 H  HH21 . ARG A 1 282 ? 16.80966  -10.07064 -11.65539 1.000 22.22852  ? 274 ARG A HH21 1 
ATOM   4228 H  HH22 . ARG A 1 282 ? 17.89074  -9.23045  -12.24203 1.000 22.22852  ? 274 ARG A HH22 1 
ATOM   4229 N  N    . HIS A 1 283 ? 11.41801  -10.47200 -17.63349 1.000 17.31305  ? 275 HIS A N    1 
ATOM   4230 C  CA   . HIS A 1 283 ? 10.80439  -11.06795 -18.81604 1.000 23.89292  ? 275 HIS A CA   1 
ATOM   4231 C  C    . HIS A 1 283 ? 11.69954  -12.10517 -19.48366 1.000 22.33568  ? 275 HIS A C    1 
ATOM   4232 O  O    . HIS A 1 283 ? 11.21057  -12.87825 -20.31064 1.000 23.58080  ? 275 HIS A O    1 
ATOM   4233 C  CB   . HIS A 1 283 ? 10.40860  -9.98472  -19.84109 1.000 21.45099  ? 275 HIS A CB   1 
ATOM   4234 C  CG   . HIS A 1 283 ? 11.56408  -9.18658  -20.37084 1.000 25.00629  ? 275 HIS A CG   1 
ATOM   4235 N  ND1  . HIS A 1 283 ? 12.39091  -9.64286  -21.37367 1.000 24.69756  ? 275 HIS A ND1  1 
ATOM   4236 C  CD2  . HIS A 1 283 ? 12.03396  -7.96354  -20.02701 1.000 27.25009  ? 275 HIS A CD2  1 
ATOM   4237 C  CE1  . HIS A 1 283 ? 13.32282  -8.73917  -21.62377 1.000 26.50435  ? 275 HIS A CE1  1 
ATOM   4238 N  NE2  . HIS A 1 283 ? 13.12264  -7.70665  -20.82675 1.000 21.57526  ? 275 HIS A NE2  1 
ATOM   4239 H  H    . HIS A 1 283 ? 11.79693  -9.71194  -17.76883 1.000 20.75247  ? 275 HIS A H    1 
ATOM   4240 H  HA   . HIS A 1 283 ? 9.98518   -11.50851 -18.54090 1.000 28.64831  ? 275 HIS A HA   1 
ATOM   4241 H  HB2  . HIS A 1 283 ? 9.97768   -10.41498 -20.59613 1.000 25.71800  ? 275 HIS A HB2  1 
ATOM   4242 H  HB3  . HIS A 1 283 ? 9.79386   -9.36599  -19.41662 1.000 25.71800  ? 275 HIS A HB3  1 
ATOM   4243 H  HD2  . HIS A 1 283 ? 11.68540  -7.40243  -19.37238 1.000 32.67692  ? 275 HIS A HD2  1 
ATOM   4244 H  HE1  . HIS A 1 283 ? 14.00279  -8.81764  -22.25337 1.000 31.78203  ? 275 HIS A HE1  1 
ATOM   4245 N  N    . THR A 1 284 ? 12.98272  -12.15698 -19.13634 1.000 23.00052  ? 276 THR A N    1 
ATOM   4246 C  CA   . THR A 1 284 ? 13.89041  -13.16928 -19.66143 1.000 23.89045  ? 276 THR A CA   1 
ATOM   4247 C  C    . THR A 1 284 ? 14.89847  -13.52470 -18.57931 1.000 20.43221  ? 276 THR A C    1 
ATOM   4248 O  O    . THR A 1 284 ? 15.33036  -12.65433 -17.82280 1.000 26.65861  ? 276 THR A O    1 
ATOM   4249 C  CB   . THR A 1 284 ? 14.62653  -12.67256 -20.91561 1.000 24.24277  ? 276 THR A CB   1 
ATOM   4250 O  OG1  . THR A 1 284 ? 13.67033  -12.23386 -21.88543 1.000 23.51241  ? 276 THR A OG1  1 
ATOM   4251 C  CG2  . THR A 1 284 ? 15.49088  -13.77193 -21.52450 1.000 27.32987  ? 276 THR A CG2  1 
ATOM   4252 H  H    . THR A 1 284 ? 13.35624  -11.60810 -18.58970 1.000 27.57744  ? 276 THR A H    1 
ATOM   4253 H  HA   . THR A 1 284 ? 13.38847  -13.96496 -19.89773 1.000 28.64534  ? 276 THR A HA   1 
ATOM   4254 H  HB   . THR A 1 284 ? 15.20989  -11.93773 -20.66942 1.000 29.06814  ? 276 THR A HB   1 
ATOM   4255 H  HG1  . THR A 1 284 ? 13.15245  -11.66816 -21.54280 1.000 28.19170  ? 276 THR A HG1  1 
ATOM   4256 H  HG21 . THR A 1 284 ? 15.95250  -13.43515 -22.30833 1.000 32.77266  ? 276 THR A HG21 1 
ATOM   4257 H  HG22 . THR A 1 284 ? 16.14777  -14.07393 -20.87782 1.000 32.77266  ? 276 THR A HG22 1 
ATOM   4258 H  HG23 . THR A 1 284 ? 14.93637  -14.52409 -21.78467 1.000 32.77266  ? 276 THR A HG23 1 
ATOM   4259 N  N    . THR A 1 285 ? 15.28752  -14.79412 -18.51986 1.000 28.03238  ? 277 THR A N    1 
ATOM   4260 C  CA   . THR A 1 285 ? 16.29210  -15.21317 -17.55260 1.000 23.10782  ? 277 THR A CA   1 
ATOM   4261 C  C    . THR A 1 285 ? 17.62685  -14.55453 -17.87504 1.000 22.61863  ? 277 THR A C    1 
ATOM   4262 O  O    . THR A 1 285 ? 18.06669  -14.56576 -19.02589 1.000 31.43266  ? 277 THR A O    1 
ATOM   4263 C  CB   . THR A 1 285 ? 16.42229  -16.73272 -17.56227 1.000 31.64014  ? 277 THR A CB   1 
ATOM   4264 O  OG1  . THR A 1 285 ? 15.18508  -17.30503 -17.12194 1.000 23.45806  ? 277 THR A OG1  1 
ATOM   4265 C  CG2  . THR A 1 285 ? 17.54327  -17.18731 -16.62793 1.000 31.74013  ? 277 THR A CG2  1 
ATOM   4266 H  H    . THR A 1 285 ? 14.98832  -15.42427 -19.02284 1.000 33.61567  ? 277 THR A H    1 
ATOM   4267 H  HA   . THR A 1 285 ? 16.02736  -14.94090 -16.66003 1.000 27.70619  ? 277 THR A HA   1 
ATOM   4268 H  HB   . THR A 1 285 ? 16.63354  -17.03766 -18.45853 1.000 37.94498  ? 277 THR A HB   1 
ATOM   4269 H  HG1  . THR A 1 285 ? 15.25808  -18.14008 -17.06750 1.000 28.12648  ? 277 THR A HG1  1 
ATOM   4270 H  HG21 . THR A 1 285 ? 17.56109  -18.15585 -16.57782 1.000 38.06497  ? 277 THR A HG21 1 
ATOM   4271 H  HG22 . THR A 1 285 ? 18.39916  -16.87343 -16.95936 1.000 38.06497  ? 277 THR A HG22 1 
ATOM   4272 H  HG23 . THR A 1 285 ? 17.39950  -16.82864 -15.73822 1.000 38.06497  ? 277 THR A HG23 1 
ATOM   4273 N  N    . ALA A 1 286 ? 18.26590  -13.96852 -16.86332 1.000 20.72590  ? 278 ALA A N    1 
ATOM   4274 C  CA   . ALA A 1 286 ? 19.57215  -13.31773 -17.04450 1.000 24.69080  ? 278 ALA A CA   1 
ATOM   4275 C  C    . ALA A 1 286 ? 20.70570  -14.25820 -16.61695 1.000 31.91262  ? 278 ALA A C    1 
ATOM   4276 O  O    . ALA A 1 286 ? 20.48380  -15.20336 -15.84518 1.000 26.50997  ? 278 ALA A O    1 
ATOM   4277 C  CB   . ALA A 1 286 ? 19.63838  -12.02249 -16.25752 1.000 28.65453  ? 278 ALA A CB   1 
ATOM   4278 H  H    . ALA A 1 286 ? 17.96657  -13.93186 -16.05792 1.000 24.84789  ? 278 ALA A H    1 
ATOM   4279 H  HA   . ALA A 1 286 ? 19.68901  -13.10065 -17.98264 1.000 29.60577  ? 278 ALA A HA   1 
ATOM   4280 H  HB1  . ALA A 1 286 ? 20.51096  -11.61890 -16.38643 1.000 34.36224  ? 278 ALA A HB1  1 
ATOM   4281 H  HB2  . ALA A 1 286 ? 18.94613  -11.42294 -16.57726 1.000 34.36224  ? 278 ALA A HB2  1 
ATOM   4282 H  HB3  . ALA A 1 286 ? 19.49940  -12.21673 -15.31738 1.000 34.36224  ? 278 ALA A HB3  1 
ATOM   4283 N  N    . VAL A 1 299 ? 30.48146  -9.59423  -14.90866 1.000 43.95213  ? 291 VAL A N    1 
ATOM   4284 C  CA   . VAL A 1 299 ? 29.22458  -9.65278  -15.65015 1.000 39.44156  ? 291 VAL A CA   1 
ATOM   4285 C  C    . VAL A 1 299 ? 28.83870  -8.24568  -16.10672 1.000 45.50813  ? 291 VAL A C    1 
ATOM   4286 O  O    . VAL A 1 299 ? 28.84386  -7.30456  -15.30914 1.000 43.43177  ? 291 VAL A O    1 
ATOM   4287 C  CB   . VAL A 1 299 ? 28.09542  -10.26704 -14.80777 1.000 45.12729  ? 291 VAL A CB   1 
ATOM   4288 C  CG1  . VAL A 1 299 ? 26.86663  -10.54560 -15.68183 1.000 48.66174  ? 291 VAL A CG1  1 
ATOM   4289 C  CG2  . VAL A 1 299 ? 28.56493  -11.53587 -14.12660 1.000 40.47828  ? 291 VAL A CG2  1 
ATOM   4290 H  HA   . VAL A 1 299 ? 29.34760  -10.21975 -16.42752 1.000 47.30668  ? 291 VAL A HA   1 
ATOM   4291 H  HB   . VAL A 1 299 ? 27.84062  -9.63418  -14.11823 1.000 54.12955  ? 291 VAL A HB   1 
ATOM   4292 H  HG11 . VAL A 1 299 ? 26.16954  -10.93568 -15.13156 1.000 58.37090  ? 291 VAL A HG11 1 
ATOM   4293 H  HG12 . VAL A 1 299 ? 26.55648  -9.71064  -16.06594 1.000 58.37090  ? 291 VAL A HG12 1 
ATOM   4294 H  HG13 . VAL A 1 299 ? 27.11472  -11.16258 -16.38801 1.000 58.37090  ? 291 VAL A HG13 1 
ATOM   4295 H  HG21 . VAL A 1 299 ? 27.82861  -11.91374 -13.62069 1.000 48.55074  ? 291 VAL A HG21 1 
ATOM   4296 H  HG22 . VAL A 1 299 ? 28.86008  -12.16631 -14.80213 1.000 48.55074  ? 291 VAL A HG22 1 
ATOM   4297 H  HG23 . VAL A 1 299 ? 29.29977  -11.32118 -13.53094 1.000 48.55074  ? 291 VAL A HG23 1 
ATOM   4298 N  N    . ASN A 1 300 ? 28.49983  -8.10225  -17.38592 1.000 38.96337  ? 292 ASN A N    1 
ATOM   4299 C  CA   . ASN A 1 300 ? 28.10131  -6.80938  -17.92210 1.000 33.89095  ? 292 ASN A CA   1 
ATOM   4300 C  C    . ASN A 1 300 ? 26.68163  -6.47699  -17.48728 1.000 33.06671  ? 292 ASN A C    1 
ATOM   4301 O  O    . ASN A 1 300 ? 25.80749  -7.34871  -17.44216 1.000 34.62093  ? 292 ASN A O    1 
ATOM   4302 C  CB   . ASN A 1 300 ? 28.19590  -6.80692  -19.44808 1.000 33.59523  ? 292 ASN A CB   1 
ATOM   4303 C  CG   . ASN A 1 300 ? 28.11765  -5.40125  -20.03718 1.000 43.89783  ? 292 ASN A CG   1 
ATOM   4304 O  OD1  . ASN A 1 300 ? 27.02881  -4.83732  -20.19792 1.000 31.61091  ? 292 ASN A OD1  1 
ATOM   4305 N  ND2  . ASN A 1 300 ? 29.27992  -4.82235  -20.34481 1.000 51.33318  ? 292 ASN A ND2  1 
ATOM   4306 H  H    . ASN A 1 300 ? 28.49331  -8.74035  -17.96244 1.000 46.73285  ? 292 ASN A H    1 
ATOM   4307 H  HA   . ASN A 1 300 ? 28.69654  -6.12159  -17.58514 1.000 40.64595  ? 292 ASN A HA   1 
ATOM   4308 H  HB2  . ASN A 1 300 ? 29.04308  -7.19763  -19.71368 1.000 40.29108  ? 292 ASN A HB2  1 
ATOM   4309 H  HB3  . ASN A 1 300 ? 27.46223  -7.32679  -19.81188 1.000 40.29108  ? 292 ASN A HB3  1 
ATOM   4310 H  HD21 . ASN A 1 300 ? 29.29046  -4.03031  -20.67971 1.000 61.57663  ? 292 ASN A HD21 1 
ATOM   4311 H  HD22 . ASN A 1 300 ? 30.01844  -5.24130  -20.20816 1.000 61.57663  ? 292 ASN A HD22 1 
ATOM   4312 N  N    . ILE A 1 301 ? 26.45286  -5.19809  -17.18116 1.000 26.94221  ? 293 ILE A N    1 
ATOM   4313 C  CA   . ILE A 1 301 ? 25.15762  -4.78454  -16.66039 1.000 31.74234  ? 293 ILE A CA   1 
ATOM   4314 C  C    . ILE A 1 301 ? 24.06003  -4.88196  -17.71255 1.000 29.81359  ? 293 ILE A C    1 
ATOM   4315 O  O    . ILE A 1 301 ? 22.87283  -4.87560  -17.35751 1.000 23.83774  ? 293 ILE A O    1 
ATOM   4316 C  CB   . ILE A 1 301 ? 25.26071  -3.35872  -16.08663 1.000 28.60706  ? 293 ILE A CB   1 
ATOM   4317 C  CG1  . ILE A 1 301 ? 23.95933  -2.96991  -15.37383 1.000 24.29035  ? 293 ILE A CG1  1 
ATOM   4318 C  CG2  . ILE A 1 301 ? 25.58109  -2.36292  -17.19309 1.000 32.48807  ? 293 ILE A CG2  1 
ATOM   4319 C  CD1  . ILE A 1 301 ? 24.08361  -1.77812  -14.44124 1.000 36.98116  ? 293 ILE A CD1  1 
ATOM   4320 H  H    . ILE A 1 301 ? 27.02518  -4.56179  -17.26581 1.000 32.30746  ? 293 ILE A H    1 
ATOM   4321 H  HA   . ILE A 1 301 ? 24.90754  -5.38412  -15.94008 1.000 38.06762  ? 293 ILE A HA   1 
ATOM   4322 H  HB   . ILE A 1 301 ? 25.98144  -3.34325  -15.43763 1.000 34.30528  ? 293 ILE A HB   1 
ATOM   4323 H  HG12 . ILE A 1 301 ? 23.29400  -2.74900  -16.04422 1.000 29.12523  ? 293 ILE A HG12 1 
ATOM   4324 H  HG13 . ILE A 1 301 ? 23.65915  -3.72556  -14.84489 1.000 29.12523  ? 293 ILE A HG13 1 
ATOM   4325 H  HG21 . ILE A 1 301 ? 25.67770  -1.47940  -16.80455 1.000 38.96250  ? 293 ILE A HG21 1 
ATOM   4326 H  HG22 . ILE A 1 301 ? 26.40850  -2.62648  -17.62531 1.000 38.96250  ? 293 ILE A HG22 1 
ATOM   4327 H  HG23 . ILE A 1 301 ? 24.85639  -2.36329  -17.83785 1.000 38.96250  ? 293 ILE A HG23 1 
ATOM   4328 H  HD11 . ILE A 1 301 ? 23.22221  -1.60879  -14.02867 1.000 44.35420  ? 293 ILE A HD11 1 
ATOM   4329 H  HD12 . ILE A 1 301 ? 24.74346  -1.97840  -13.75904 1.000 44.35420  ? 293 ILE A HD12 1 
ATOM   4330 H  HD13 . ILE A 1 301 ? 24.36271  -1.00354  -14.95411 1.000 44.35420  ? 293 ILE A HD13 1 
ATOM   4331 N  N    . THR A 1 302 ? 24.42493  -4.98020  -18.99841 1.000 23.76030  ? 294 THR A N    1 
ATOM   4332 C  CA   . THR A 1 302 ? 23.42256  -5.15665  -20.04304 1.000 24.66951  ? 294 THR A CA   1 
ATOM   4333 C  C    . THR A 1 302 ? 22.57839  -6.38922  -19.77623 1.000 25.24721  ? 294 THR A C    1 
ATOM   4334 O  O    . THR A 1 302 ? 21.41781  -6.44529  -20.19332 1.000 21.03207  ? 294 THR A O    1 
ATOM   4335 C  CB   . THR A 1 302 ? 24.08210  -5.28305  -21.42451 1.000 20.91688  ? 294 THR A CB   1 
ATOM   4336 O  OG1  . THR A 1 302 ? 25.08462  -6.30685  -21.37722 1.000 34.36541  ? 294 THR A OG1  1 
ATOM   4337 C  CG2  . THR A 1 302 ? 24.71079  -3.97100  -21.84819 1.000 35.13056  ? 294 THR A CG2  1 
ATOM   4338 H  H    . THR A 1 302 ? 25.23565  -4.94769  -19.28350 1.000 28.48917  ? 294 THR A H    1 
ATOM   4339 H  HA   . THR A 1 302 ? 22.85508  -4.37008  -20.05623 1.000 29.58023  ? 294 THR A HA   1 
ATOM   4340 H  HB   . THR A 1 302 ? 23.41042  -5.51499  -22.08478 1.000 25.07707  ? 294 THR A HB   1 
ATOM   4341 H  HG1  . THR A 1 302 ? 25.67749  -6.10279  -20.81824 1.000 41.21531  ? 294 THR A HG1  1 
ATOM   4342 H  HG21 . THR A 1 302 ? 25.18007  -4.08438  -22.68951 1.000 42.13348  ? 294 THR A HG21 1 
ATOM   4343 H  HG22 . THR A 1 302 ? 24.02430  -3.29478  -21.95930 1.000 42.13348  ? 294 THR A HG22 1 
ATOM   4344 H  HG23 . THR A 1 302 ? 25.34092  -3.67209  -21.17404 1.000 42.13348  ? 294 THR A HG23 1 
ATOM   4345 N  N    . SER A 1 303 ? 23.16568  -7.41155  -19.14507 1.000 21.02171  ? 295 SER A N    1 
ATOM   4346 C  CA   . SER A 1 303 ? 22.43169  -8.64469  -18.88328 1.000 21.94013  ? 295 SER A CA   1 
ATOM   4347 C  C    . SER A 1 303 ? 21.21846  -8.39916  -17.99658 1.000 26.46419  ? 295 SER A C    1 
ATOM   4348 O  O    . SER A 1 303 ? 20.20607  -9.10068  -18.12412 1.000 20.79778  ? 295 SER A O    1 
ATOM   4349 C  CB   . SER A 1 303 ? 23.35711  -9.67491  -18.23956 1.000 29.34383  ? 295 SER A CB   1 
ATOM   4350 O  OG   . SER A 1 303 ? 22.66353  -10.89210 -18.03276 1.000 42.34811  ? 295 SER A OG   1 
ATOM   4351 H  H    . SER A 1 303 ? 23.97805  -7.41363  -18.86285 1.000 25.20287  ? 295 SER A H    1 
ATOM   4352 H  HA   . SER A 1 303 ? 22.11707  -9.00552  -19.72691 1.000 26.30496  ? 295 SER A HA   1 
ATOM   4353 H  HB2  . SER A 1 303 ? 24.11289  -9.83470  -18.82622 1.000 35.18941  ? 295 SER A HB2  1 
ATOM   4354 H  HB3  . SER A 1 303 ? 23.66632  -9.33540  -17.38514 1.000 35.18941  ? 295 SER A HB3  1 
ATOM   4355 H  HG   . SER A 1 303 ? 23.18092  -11.46486 -17.70133 1.000 50.79454  ? 295 SER A HG   1 
ATOM   4356 N  N    . GLN A 1 304 ? 21.30202  -7.42188  -17.08924 1.000 19.31158  ? 296 GLN A N    1 
ATOM   4357 C  CA   . GLN A 1 304 ? 20.15560  -7.07833  -16.25510 1.000 19.48879  ? 296 GLN A CA   1 
ATOM   4358 C  C    . GLN A 1 304 ? 19.20676  -6.14993  -17.00216 1.000 19.60116  ? 296 GLN A C    1 
ATOM   4359 O  O    . GLN A 1 304 ? 17.99568  -6.39362  -17.06155 1.000 18.16834  ? 296 GLN A O    1 
ATOM   4360 C  CB   . GLN A 1 304 ? 20.62938  -6.42726  -14.95278 1.000 18.05793  ? 296 GLN A CB   1 
ATOM   4361 C  CG   . GLN A 1 304 ? 21.32651  -7.39295  -13.97674 1.000 24.63676  ? 296 GLN A CG   1 
ATOM   4362 C  CD   . GLN A 1 304 ? 20.35654  -8.04559  -13.01483 1.000 18.18823  ? 296 GLN A CD   1 
ATOM   4363 O  OE1  . GLN A 1 304 ? 19.14704  -7.87227  -13.12507 1.000 20.98690  ? 296 GLN A OE1  1 
ATOM   4364 N  NE2  . GLN A 1 304 ? 20.88366  -8.78827  -12.05809 1.000 30.73439  ? 296 GLN A NE2  1 
ATOM   4365 H  H    . GLN A 1 304 ? 22.00497  -6.94923  -16.94071 1.000 23.15071  ? 296 GLN A H    1 
ATOM   4366 H  HA   . GLN A 1 304 ? 19.67504  -7.88849  -16.02361 1.000 23.36336  ? 296 GLN A HA   1 
ATOM   4367 H  HB2  . GLN A 1 304 ? 21.26049  -5.72352  -15.17039 1.000 21.64633  ? 296 GLN A HB2  1 
ATOM   4368 H  HB3  . GLN A 1 304 ? 19.85977  -6.05312  -14.49604 1.000 21.64633  ? 296 GLN A HB3  1 
ATOM   4369 H  HG2  . GLN A 1 304 ? 21.76527  -8.09400  -14.48361 1.000 29.54092  ? 296 GLN A HG2  1 
ATOM   4370 H  HG3  . GLN A 1 304 ? 21.98067  -6.90053  -13.45665 1.000 29.54092  ? 296 GLN A HG3  1 
ATOM   4371 H  HE21 . GLN A 1 304 ? 21.73714  -8.88034  -12.00612 1.000 36.85808  ? 296 GLN A HE21 1 
ATOM   4372 H  HE22 . GLN A 1 304 ? 20.37338  -9.17974  -11.48716 1.000 36.85808  ? 296 GLN A HE22 1 
ATOM   4373 N  N    . ILE A 1 305 ? 19.74854  -5.09473  -17.60887 1.000 20.41355  ? 297 ILE A N    1 
ATOM   4374 C  CA   . ILE A 1 305 ? 18.89999  -4.12312  -18.29636 1.000 24.78797  ? 297 ILE A CA   1 
ATOM   4375 C  C    . ILE A 1 305 ? 18.05377  -4.80901  -19.35559 1.000 22.68960  ? 297 ILE A C    1 
ATOM   4376 O  O    . ILE A 1 305 ? 16.87662  -4.47938  -19.53867 1.000 20.76939  ? 297 ILE A O    1 
ATOM   4377 C  CB   . ILE A 1 305 ? 19.75833  -3.01030  -18.92585 1.000 19.61790  ? 297 ILE A CB   1 
ATOM   4378 C  CG1  . ILE A 1 305 ? 20.56079  -2.26823  -17.85960 1.000 25.83562  ? 297 ILE A CG1  1 
ATOM   4379 C  CG2  . ILE A 1 305 ? 18.91598  -2.03462  -19.71294 1.000 19.51524  ? 297 ILE A CG2  1 
ATOM   4380 C  CD1  . ILE A 1 305 ? 21.73180  -1.45141  -18.44078 1.000 25.64888  ? 297 ILE A CD1  1 
ATOM   4381 H  H    . ILE A 1 305 ? 20.59024  -4.92055  -17.63708 1.000 24.47307  ? 297 ILE A H    1 
ATOM   4382 H  HA   . ILE A 1 305 ? 18.30870  -3.72408  -17.63906 1.000 29.72237  ? 297 ILE A HA   1 
ATOM   4383 H  HB   . ILE A 1 305 ? 20.37507  -3.44166  -19.53777 1.000 23.51829  ? 297 ILE A HB   1 
ATOM   4384 H  HG12 . ILE A 1 305 ? 19.97157  -1.65498  -17.39307 1.000 30.97956  ? 297 ILE A HG12 1 
ATOM   4385 H  HG13 . ILE A 1 305 ? 20.92791  -2.91444  -17.23627 1.000 30.97956  ? 297 ILE A HG13 1 
ATOM   4386 H  HG21 . ILE A 1 305 ? 19.48097  -1.31145  -20.02712 1.000 23.39510  ? 297 ILE A HG21 1 
ATOM   4387 H  HG22 . ILE A 1 305 ? 18.51989  -2.49693  -20.46810 1.000 23.39510  ? 297 ILE A HG22 1 
ATOM   4388 H  HG23 . ILE A 1 305 ? 18.21868  -1.68343  -19.13732 1.000 23.39510  ? 297 ILE A HG23 1 
ATOM   4389 H  HD11 . ILE A 1 305 ? 22.22194  -1.03958  -17.71204 1.000 30.75547  ? 297 ILE A HD11 1 
ATOM   4390 H  HD12 . ILE A 1 305 ? 22.31546  -2.04577  -18.93774 1.000 30.75547  ? 297 ILE A HD12 1 
ATOM   4391 H  HD13 . ILE A 1 305 ? 21.37770  -0.76685  -19.02976 1.000 30.75547  ? 297 ILE A HD13 1 
ATOM   4392 N  N    . ASN A 1 306 ? 18.64997  -5.73606  -20.09964 1.000 14.81802  ? 298 ASN A N    1 
ATOM   4393 C  CA   . ASN A 1 306 ? 17.98452  -6.33746  -21.24272 1.000 15.88489  ? 298 ASN A CA   1 
ATOM   4394 C  C    . ASN A 1 306 ? 17.01895  -7.44001  -20.84883 1.000 18.77615  ? 298 ASN A C    1 
ATOM   4395 O  O    . ASN A 1 306 ? 16.43897  -8.06610  -21.74022 1.000 20.65866  ? 298 ASN A O    1 
ATOM   4396 C  CB   . ASN A 1 306 ? 19.02145  -6.89595  -22.21417 1.000 21.82642  ? 298 ASN A CB   1 
ATOM   4397 C  CG   . ASN A 1 306 ? 19.87375  -5.81771  -22.83836 1.000 23.81152  ? 298 ASN A CG   1 
ATOM   4398 O  OD1  . ASN A 1 306 ? 19.68033  -4.62988  -22.58808 1.000 19.41233  ? 298 ASN A OD1  1 
ATOM   4399 N  ND2  . ASN A 1 306 ? 20.82628  -6.22812  -23.66182 1.000 27.91660  ? 298 ASN A ND2  1 
ATOM   4400 H  H    . ASN A 1 306 ? 19.44469  -6.03328  -19.95937 1.000 17.75844  ? 298 ASN A H    1 
ATOM   4401 H  HA   . ASN A 1 306 ? 17.48003  -5.64892  -21.70349 1.000 19.03868  ? 298 ASN A HA   1 
ATOM   4402 H  HB2  . ASN A 1 306 ? 19.60778  -7.50334  -21.73647 1.000 26.16851  ? 298 ASN A HB2  1 
ATOM   4403 H  HB3  . ASN A 1 306 ? 18.56457  -7.36830  -22.92764 1.000 26.16851  ? 298 ASN A HB3  1 
ATOM   4404 H  HD21 . ASN A 1 306 ? 21.34046  -5.65466  -24.04439 1.000 33.47674  ? 298 ASN A HD21 1 
ATOM   4405 H  HD22 . ASN A 1 306 ? 20.93065  -7.06809  -23.81399 1.000 33.47674  ? 298 ASN A HD22 1 
ATOM   4406 N  N    . THR A 1 307 ? 16.80819  -7.67498  -19.54822 1.000 18.29009  ? 299 THR A N    1 
ATOM   4407 C  CA   . THR A 1 307 ? 15.93325  -8.75238  -19.09873 1.000 19.51383  ? 299 THR A CA   1 
ATOM   4408 C  C    . THR A 1 307 ? 14.83554  -8.29947  -18.14011 1.000 19.15722  ? 299 THR A C    1 
ATOM   4409 O  O    . THR A 1 307 ? 14.02500  -9.13533  -17.71803 1.000 20.58573  ? 299 THR A O    1 
ATOM   4410 C  CB   . THR A 1 307 ? 16.74981  -9.87347  -18.42552 1.000 21.94362  ? 299 THR A CB   1 
ATOM   4411 O  OG1  . THR A 1 307 ? 17.57137  -9.31944  -17.39145 1.000 22.91409  ? 299 THR A OG1  1 
ATOM   4412 C  CG2  . THR A 1 307 ? 17.63289  -10.57817 -19.43259 1.000 22.66464  ? 299 THR A CG2  1 
ATOM   4413 H  H    . THR A 1 307 ? 17.16305  -7.22109  -18.90973 1.000 21.92491  ? 299 THR A H    1 
ATOM   4414 H  HA   . THR A 1 307 ? 15.50135  -9.12743  -19.88212 1.000 23.39340  ? 299 THR A HA   1 
ATOM   4415 H  HB   . THR A 1 307 ? 16.13932  -10.52425 -18.04515 1.000 26.30915  ? 299 THR A HB   1 
ATOM   4416 H  HG1  . THR A 1 307 ? 18.35822  -9.22428  -17.66967 1.000 27.47372  ? 299 THR A HG1  1 
ATOM   4417 H  HG21 . THR A 1 307 ? 18.12294  -11.29482 -18.99997 1.000 27.17437  ? 299 THR A HG21 1 
ATOM   4418 H  HG22 . THR A 1 307 ? 17.09081  -10.95254 -20.14455 1.000 27.17437  ? 299 THR A HG22 1 
ATOM   4419 H  HG23 . THR A 1 307 ? 18.26565  -9.95055  -19.81550 1.000 27.17437  ? 299 THR A HG23 1 
ATOM   4420 N  N    . VAL A 1 308 ? 14.76804  -7.01364  -17.79309 1.000 18.56999  ? 300 VAL A N    1 
ATOM   4421 C  CA   . VAL A 1 308 ? 13.74099  -6.51402  -16.89333 1.000 13.47815  ? 300 VAL A CA   1 
ATOM   4422 C  C    . VAL A 1 308 ? 13.10396  -5.25532  -17.47226 1.000 20.70110  ? 300 VAL A C    1 
ATOM   4423 O  O    . VAL A 1 308 ? 13.62415  -4.62310  -18.39815 1.000 21.12252  ? 300 VAL A O    1 
ATOM   4424 C  CB   . VAL A 1 308 ? 14.31338  -6.22391  -15.48699 1.000 15.93923  ? 300 VAL A CB   1 
ATOM   4425 C  CG1  . VAL A 1 308 ? 15.17319  -7.39030  -15.00737 1.000 25.30383  ? 300 VAL A CG1  1 
ATOM   4426 C  CG2  . VAL A 1 308 ? 15.14382  -4.92248  -15.50574 1.000 21.12273  ? 300 VAL A CG2  1 
ATOM   4427 H  H    . VAL A 1 308 ? 15.31341  -6.40960  -18.07112 1.000 22.26080  ? 300 VAL A H    1 
ATOM   4428 H  HA   . VAL A 1 308 ? 13.03978  -7.18047  -16.82225 1.000 16.15058  ? 300 VAL A HA   1 
ATOM   4429 H  HB   . VAL A 1 308 ? 13.57659  -6.11245  -14.86601 1.000 19.10388  ? 300 VAL A HB   1 
ATOM   4430 H  HG11 . VAL A 1 308 ? 15.49726  -7.19721  -14.11373 1.000 30.34141  ? 300 VAL A HG11 1 
ATOM   4431 H  HG12 . VAL A 1 308 ? 14.63405  -8.19660  -14.99668 1.000 30.34141  ? 300 VAL A HG12 1 
ATOM   4432 H  HG13 . VAL A 1 308 ? 15.92194  -7.50106  -15.61400 1.000 30.34141  ? 300 VAL A HG13 1 
ATOM   4433 H  HG21 . VAL A 1 308 ? 15.57910  -4.81320  -14.64581 1.000 25.32408  ? 300 VAL A HG21 1 
ATOM   4434 H  HG22 . VAL A 1 308 ? 15.80987  -4.98297  -16.20831 1.000 25.32408  ? 300 VAL A HG22 1 
ATOM   4435 H  HG23 . VAL A 1 308 ? 14.55207  -4.17267  -15.67460 1.000 25.32408  ? 300 VAL A HG23 1 
ATOM   4436 N  N    . ASN A 1 309 ? 11.97088  -4.88329  -16.88529 1.000 17.23496  ? 301 ASN A N    1 
ATOM   4437 C  CA   . ASN A 1 309 ? 11.33005  -3.59855  -17.14528 1.000 18.76889  ? 301 ASN A CA   1 
ATOM   4438 C  C    . ASN A 1 309 ? 10.29627  -3.36210  -16.05106 1.000 18.14116  ? 301 ASN A C    1 
ATOM   4439 O  O    . ASN A 1 309 ? 9.99640   -4.24916  -15.24874 1.000 20.44881  ? 301 ASN A O    1 
ATOM   4440 C  CB   . ASN A 1 309 ? 10.69802  -3.53640  -18.54682 1.000 21.90995  ? 301 ASN A CB   1 
ATOM   4441 C  CG   . ASN A 1 309 ? 9.62197   -4.58593  -18.75764 1.000 30.02717  ? 301 ASN A CG   1 
ATOM   4442 O  OD1  . ASN A 1 309 ? 9.89065   -5.67993  -19.26318 1.000 22.31924  ? 301 ASN A OD1  1 
ATOM   4443 N  ND2  . ASN A 1 309 ? 8.39605   -4.25974  -18.36789 1.000 21.41559  ? 301 ASN A ND2  1 
ATOM   4444 H  H    . ASN A 1 309 ? 11.54339  -5.36908  -16.31883 1.000 20.65876  ? 301 ASN A H    1 
ATOM   4445 H  HA   . ASN A 1 309 ? 11.99342  -2.89261  -17.09538 1.000 22.49948  ? 301 ASN A HA   1 
ATOM   4446 H  HB2  . ASN A 1 309 ? 10.29337  -2.66376  -18.67191 1.000 26.26876  ? 301 ASN A HB2  1 
ATOM   4447 H  HB3  . ASN A 1 309 ? 11.38989  -3.67962  -19.21143 1.000 26.26876  ? 301 ASN A HB3  1 
ATOM   4448 H  HD21 . ASN A 1 309 ? 7.75057   -4.81959  -18.46549 1.000 25.67552  ? 301 ASN A HD21 1 
ATOM   4449 H  HD22 . ASN A 1 309 ? 8.24709   -3.48852  -18.01772 1.000 25.67552  ? 301 ASN A HD22 1 
ATOM   4450 N  N    . LEU A 1 310 ? 9.78410   -2.13621  -15.99719 1.000 20.56460  ? 302 LEU A N    1 
ATOM   4451 C  CA   . LEU A 1 310 ? 8.73294   -1.81341  -15.04401 1.000 15.85087  ? 302 LEU A CA   1 
ATOM   4452 C  C    . LEU A 1 310 ? 7.39538   -2.40042  -15.49510 1.000 20.63476  ? 302 LEU A C    1 
ATOM   4453 O  O    . LEU A 1 310 ? 7.06270   -2.39594  -16.68328 1.000 17.34940  ? 302 LEU A O    1 
ATOM   4454 C  CB   . LEU A 1 310 ? 8.61560   -0.29975  -14.87961 1.000 18.63963  ? 302 LEU A CB   1 
ATOM   4455 C  CG   . LEU A 1 310 ? 9.85872   0.42611   -14.35774 1.000 15.57969  ? 302 LEU A CG   1 
ATOM   4456 C  CD1  . LEU A 1 310 ? 9.52157   1.88642   -14.08933 1.000 20.55974  ? 302 LEU A CD1  1 
ATOM   4457 C  CD2  . LEU A 1 310 ? 10.41625  -0.23942  -13.10273 1.000 20.58828  ? 302 LEU A CD2  1 
ATOM   4458 H  H    . LEU A 1 310 ? 10.02722  -1.48081  -16.49813 1.000 24.65432  ? 302 LEU A H    1 
ATOM   4459 H  HA   . LEU A 1 310 ? 8.95134   -2.19710  -14.18031 1.000 18.99786  ? 302 LEU A HA   1 
ATOM   4460 H  HB2  . LEU A 1 310 ? 8.40495   0.08164   -15.74625 1.000 22.34437  ? 302 LEU A HB2  1 
ATOM   4461 H  HB3  . LEU A 1 310 ? 7.89625   -0.11984  -14.25426 1.000 22.34437  ? 302 LEU A HB3  1 
ATOM   4462 H  HG   . LEU A 1 310 ? 10.55500  0.38069   -15.03156 1.000 18.67244  ? 302 LEU A HG   1 
ATOM   4463 H  HD11 . LEU A 1 310 ? 10.31887  2.34244   -13.77746 1.000 24.64850  ? 302 LEU A HD11 1 
ATOM   4464 H  HD12 . LEU A 1 310 ? 9.20746   2.29428   -14.91145 1.000 24.64850  ? 302 LEU A HD12 1 
ATOM   4465 H  HD13 . LEU A 1 310 ? 8.82861   1.93121   -13.41206 1.000 24.64850  ? 302 LEU A HD13 1 
ATOM   4466 H  HD21 . LEU A 1 310 ? 11.17323  0.27538   -12.78200 1.000 24.68274  ? 302 LEU A HD21 1 
ATOM   4467 H  HD22 . LEU A 1 310 ? 9.72304   -0.26576  -12.42474 1.000 24.68274  ? 302 LEU A HD22 1 
ATOM   4468 H  HD23 . LEU A 1 310 ? 10.69861  -1.14107  -13.32230 1.000 24.68274  ? 302 LEU A HD23 1 
ATOM   4469 N  N    . ASN A 1 311 ? 6.63536   -2.91627  -14.53176 1.000 21.62455  ? 303 ASN A N    1 
ATOM   4470 C  CA   . ASN A 1 311 ? 5.31219   -3.46507  -14.79859 1.000 16.55413  ? 303 ASN A CA   1 
ATOM   4471 C  C    . ASN A 1 311 ? 4.31209   -2.33437  -14.96678 1.000 15.82788  ? 303 ASN A C    1 
ATOM   4472 O  O    . ASN A 1 311 ? 4.08067   -1.58028  -14.01773 1.000 18.39271  ? 303 ASN A O    1 
ATOM   4473 C  CB   . ASN A 1 311 ? 4.89374   -4.35267  -13.64608 1.000 20.12236  ? 303 ASN A CB   1 
ATOM   4474 C  CG   . ASN A 1 311 ? 3.62120   -5.11026  -13.91449 1.000 28.06529  ? 303 ASN A CG   1 
ATOM   4475 O  OD1  . ASN A 1 311 ? 2.87757   -4.81492  -14.85914 1.000 19.78797  ? 303 ASN A OD1  1 
ATOM   4476 N  ND2  . ASN A 1 311 ? 3.35567   -6.10807  -13.06836 1.000 22.42891  ? 303 ASN A ND2  1 
ATOM   4477 H  H    . ASN A 1 311 ? 6.86725   -2.96027  -13.70478 1.000 25.92627  ? 303 ASN A H    1 
ATOM   4478 H  HA   . ASN A 1 311 ? 5.32469   -3.98727  -15.61594 1.000 19.84177  ? 303 ASN A HA   1 
ATOM   4479 H  HB2  . ASN A 1 311 ? 5.59603   -4.99988  -13.47636 1.000 24.12364  ? 303 ASN A HB2  1 
ATOM   4480 H  HB3  . ASN A 1 311 ? 4.75293   -3.80209  -12.86000 1.000 24.12364  ? 303 ASN A HB3  1 
ATOM   4481 H  HD21 . ASN A 1 311 ? 2.64299   -6.57883  -13.16875 1.000 26.89151  ? 303 ASN A HD21 1 
ATOM   4482 H  HD22 . ASN A 1 311 ? 3.89728   -6.28013  -12.42288 1.000 26.89151  ? 303 ASN A HD22 1 
ATOM   4483 N  N    . PRO A 1 312 ? 3.72239   -2.15183  -16.14947 1.000 18.58063  ? 304 PRO A N    1 
ATOM   4484 C  CA   . PRO A 1 312 ? 2.72019   -1.08588  -16.31241 1.000 22.02219  ? 304 PRO A CA   1 
ATOM   4485 C  C    . PRO A 1 312 ? 1.45257   -1.31148  -15.50504 1.000 26.99200  ? 304 PRO A C    1 
ATOM   4486 O  O    . PRO A 1 312 ? 0.65778   -0.36873  -15.37415 1.000 28.24140  ? 304 PRO A O    1 
ATOM   4487 C  CB   . PRO A 1 312 ? 2.42456   -1.09344  -17.81969 1.000 18.12656  ? 304 PRO A CB   1 
ATOM   4488 C  CG   . PRO A 1 312 ? 2.85018   -2.43317  -18.31887 1.000 27.81493  ? 304 PRO A CG   1 
ATOM   4489 C  CD   . PRO A 1 312 ? 3.97264   -2.90432  -17.39181 1.000 26.46418  ? 304 PRO A CD   1 
ATOM   4490 H  HA   . PRO A 1 312 ? 3.10732   -0.22939  -16.07272 1.000 26.40344  ? 304 PRO A HA   1 
ATOM   4491 H  HB2  . PRO A 1 312 ? 1.47515   -0.95869  -17.96587 1.000 21.72869  ? 304 PRO A HB2  1 
ATOM   4492 H  HB3  . PRO A 1 312 ? 2.93039   -0.38897  -18.25415 1.000 21.72869  ? 304 PRO A HB3  1 
ATOM   4493 H  HG2  . PRO A 1 312 ? 2.09918   -3.04613  -18.28451 1.000 33.35473  ? 304 PRO A HG2  1 
ATOM   4494 H  HG3  . PRO A 1 312 ? 3.17151   -2.35296  -19.23057 1.000 33.35473  ? 304 PRO A HG3  1 
ATOM   4495 H  HD2  . PRO A 1 312 ? 3.91302   -3.85970  -17.23498 1.000 31.73382  ? 304 PRO A HD2  1 
ATOM   4496 H  HD3  . PRO A 1 312 ? 4.84171   -2.68232  -17.76104 1.000 31.73382  ? 304 PRO A HD3  1 
ATOM   4497 N  N    . ALA A 1 313 ? 1.22498   -2.52374  -14.98963 1.000 19.36801  ? 305 ALA A N    1 
ATOM   4498 C  CA   . ALA A 1 313 ? 0.01275   -2.85327  -14.23734 1.000 24.34029  ? 305 ALA A CA   1 
ATOM   4499 C  C    . ALA A 1 313 ? 0.37248   -3.75881  -13.06823 1.000 22.50877  ? 305 ALA A C    1 
ATOM   4500 O  O    . ALA A 1 313 ? 0.03148   -4.94670  -13.04634 1.000 28.99820  ? 305 ALA A O    1 
ATOM   4501 C  CB   . ALA A 1 313 ? -1.03166  -3.51044  -15.14372 1.000 25.71356  ? 305 ALA A CB   1 
ATOM   4502 H  H    . ALA A 1 313 ? 1.77034   -3.18443  -15.06495 1.000 23.21843  ? 305 ALA A H    1 
ATOM   4503 H  HA   . ALA A 1 313 ? -0.36200  -2.03411  -13.87757 1.000 29.18516  ? 305 ALA A HA   1 
ATOM   4504 H  HB1  . ALA A 1 313 ? -1.81935  -3.71977  -14.61776 1.000 30.83309  ? 305 ALA A HB1  1 
ATOM   4505 H  HB2  . ALA A 1 313 ? -1.26378  -2.89455  -15.85626 1.000 30.83309  ? 305 ALA A HB2  1 
ATOM   4506 H  HB3  . ALA A 1 313 ? -0.65812  -4.32363  -15.51800 1.000 30.83309  ? 305 ALA A HB3  1 
ATOM   4507 N  N    . PRO A 1 314 ? 1.04482   -3.21912  -12.05963 1.000 23.23591  ? 306 PRO A N    1 
ATOM   4508 C  CA   . PRO A 1 314 ? 1.31781   -4.00377  -10.85222 1.000 26.18154  ? 306 PRO A CA   1 
ATOM   4509 C  C    . PRO A 1 314 ? 0.09590   -4.03650  -9.93811  1.000 30.12178  ? 306 PRO A C    1 
ATOM   4510 O  O    . PRO A 1 314 ? -0.90652  -3.34234  -10.14307 1.000 21.67847  ? 306 PRO A O    1 
ATOM   4511 C  CB   . PRO A 1 314 ? 2.49894   -3.26978  -10.20192 1.000 19.04282  ? 306 PRO A CB   1 
ATOM   4512 C  CG   . PRO A 1 314 ? 2.32166   -1.84588  -10.62606 1.000 20.83188  ? 306 PRO A CG   1 
ATOM   4513 C  CD   . PRO A 1 314 ? 1.60176   -1.85647  -11.98018 1.000 25.66291  ? 306 PRO A CD   1 
ATOM   4514 H  HA   . PRO A 1 314 ? 1.59044   -4.90875  -11.07037 1.000 31.39466  ? 306 PRO A HA   1 
ATOM   4515 H  HB2  . PRO A 1 314 ? 2.45487   -3.35595  -9.23676  1.000 22.82819  ? 306 PRO A HB2  1 
ATOM   4516 H  HB3  . PRO A 1 314 ? 3.33750   -3.63108  -10.52931 1.000 22.82819  ? 306 PRO A HB3  1 
ATOM   4517 H  HG2  . PRO A 1 314 ? 1.78905   -1.37796  -9.96403  1.000 24.97506  ? 306 PRO A HG2  1 
ATOM   4518 H  HG3  . PRO A 1 314 ? 3.19177   -1.42534  -10.70939 1.000 24.97506  ? 306 PRO A HG3  1 
ATOM   4519 H  HD2  . PRO A 1 314 ? 0.89440   -1.19304  -11.99996 1.000 30.77230  ? 306 PRO A HD2  1 
ATOM   4520 H  HD3  . PRO A 1 314 ? 2.22691   -1.69659  -12.70443 1.000 30.77230  ? 306 PRO A HD3  1 
ATOM   4521 N  N    . ILE A 1 315 ? 0.20558   -4.85782  -8.89755  1.000 26.30768  ? 307 ILE A N    1 
ATOM   4522 C  CA   . ILE A 1 315 ? -0.90679  -5.04515  -7.97336  1.000 28.72417  ? 307 ILE A CA   1 
ATOM   4523 C  C    . ILE A 1 315 ? -1.08019  -3.78266  -7.14045  1.000 24.96932  ? 307 ILE A C    1 
ATOM   4524 O  O    . ILE A 1 315 ? -0.17789  -3.38871  -6.39370  1.000 22.53078  ? 307 ILE A O    1 
ATOM   4525 C  CB   . ILE A 1 315 ? -0.67618  -6.26954  -7.08113  1.000 27.05418  ? 307 ILE A CB   1 
ATOM   4526 C  CG1  . ILE A 1 315 ? -0.58236  -7.52839  -7.94211  1.000 26.46883  ? 307 ILE A CG1  1 
ATOM   4527 C  CG2  . ILE A 1 315 ? -1.80089  -6.39971  -6.05596  1.000 36.96696  ? 307 ILE A CG2  1 
ATOM   4528 C  CD1  . ILE A 1 315 ? 0.13163   -8.67898  -7.25603  1.000 27.09208  ? 307 ILE A CD1  1 
ATOM   4529 H  H    . ILE A 1 315 ? 0.90862   -5.31475  -8.70637  1.000 31.54603  ? 307 ILE A H    1 
ATOM   4530 H  HA   . ILE A 1 315 ? -1.71969  -5.18647  -8.48338  1.000 34.44582  ? 307 ILE A HA   1 
ATOM   4531 H  HB   . ILE A 1 315 ? 0.16010   -6.15601  -6.60296  1.000 32.44183  ? 307 ILE A HB   1 
ATOM   4532 H  HG12 . ILE A 1 315 ? -1.47944  -7.82437  -8.16241  1.000 31.73941  ? 307 ILE A HG12 1 
ATOM   4533 H  HG13 . ILE A 1 315 ? -0.09417  -7.31704  -8.75322  1.000 31.73941  ? 307 ILE A HG13 1 
ATOM   4534 H  HG21 . ILE A 1 315 ? -1.68335  -7.22584  -5.56139  1.000 44.33716  ? 307 ILE A HG21 1 
ATOM   4535 H  HG22 . ILE A 1 315 ? -1.76476  -5.64330  -5.44979  1.000 44.33716  ? 307 ILE A HG22 1 
ATOM   4536 H  HG23 . ILE A 1 315 ? -2.65218  -6.41072  -6.52080  1.000 44.33716  ? 307 ILE A HG23 1 
ATOM   4537 H  HD11 . ILE A 1 315 ? 0.16321   -9.43667  -7.86085  1.000 32.48731  ? 307 ILE A HD11 1 
ATOM   4538 H  HD12 . ILE A 1 315 ? 1.03223   -8.40047  -7.02743  1.000 32.48731  ? 307 ILE A HD12 1 
ATOM   4539 H  HD13 . ILE A 1 315 ? -0.35493  -8.91791  -6.45163  1.000 32.48731  ? 307 ILE A HD13 1 
ATOM   4540 N  N    . LYS A 1 316 ? -2.24182  -3.13455  -7.27755  1.000 32.51435  ? 308 LYS A N    1 
ATOM   4541 C  CA   . LYS A 1 316 ? -2.54040  -1.95487  -6.47140  1.000 33.97331  ? 308 LYS A CA   1 
ATOM   4542 C  C    . LYS A 1 316 ? -3.10583  -2.34323  -5.11268  1.000 36.75907  ? 308 LYS A C    1 
ATOM   4543 O  O    . LYS A 1 316 ? -2.79229  -1.70459  -4.10134  1.000 36.97242  ? 308 LYS A O    1 
ATOM   4544 C  CB   . LYS A 1 316 ? -3.52792  -1.04531  -7.20597  1.000 40.79346  ? 308 LYS A CB   1 
ATOM   4545 C  CG   . LYS A 1 316 ? -4.03706  0.13222   -6.37209  1.000 45.28861  ? 308 LYS A CG   1 
ATOM   4546 C  CD   . LYS A 1 316 ? -4.75485  1.18234   -7.23812  1.000 46.69563  ? 308 LYS A CD   1 
ATOM   4547 C  CE   . LYS A 1 316 ? -6.02821  0.61256   -7.87047  1.000 55.85550  ? 308 LYS A CE   1 
ATOM   4548 N  NZ   . LYS A 1 316 ? -6.63640  1.57030   -8.84796  1.000 59.94638  ? 308 LYS A NZ   1 
ATOM   4549 H  H    . LYS A 1 316 ? -2.86592  -3.35756  -7.82561  1.000 38.99403  ? 308 LYS A H    1 
ATOM   4550 H  HA   . LYS A 1 316 ? -1.71861  -1.45812  -6.33428  1.000 40.74478  ? 308 LYS A HA   1 
ATOM   4551 H  HB2  . LYS A 1 316 ? -3.08939  -0.68181  -7.99112  1.000 48.92897  ? 308 LYS A HB2  1 
ATOM   4552 H  HB3  . LYS A 1 316 ? -4.29765  -1.57305  -7.47034  1.000 48.92897  ? 308 LYS A HB3  1 
ATOM   4553 H  HG2  . LYS A 1 316 ? -4.66506  -0.19386  -5.70862  1.000 54.32314  ? 308 LYS A HG2  1 
ATOM   4554 H  HG3  . LYS A 1 316 ? -3.28585  0.56252   -5.93459  1.000 54.32314  ? 308 LYS A HG3  1 
ATOM   4555 H  HD2  . LYS A 1 316 ? -5.00172  1.94030   -6.68543  1.000 56.01157  ? 308 LYS A HD2  1 
ATOM   4556 H  HD3  . LYS A 1 316 ? -4.16300  1.47014   -7.95070  1.000 56.01157  ? 308 LYS A HD3  1 
ATOM   4557 H  HE2  . LYS A 1 316 ? -5.81276  -0.20744  -8.34172  1.000 67.00341  ? 308 LYS A HE2  1 
ATOM   4558 H  HE3  . LYS A 1 316 ? -6.67948  0.43376   -7.17421  1.000 67.00341  ? 308 LYS A HE3  1 
ATOM   4559 H  HZ1  . LYS A 1 316 ? -7.36325  1.21056   -9.21454  1.000 71.91247  ? 308 LYS A HZ1  1 
ATOM   4560 H  HZ2  . LYS A 1 316 ? -6.86480  2.32412   -8.43361  1.000 71.91247  ? 308 LYS A HZ2  1 
ATOM   4561 H  HZ3  . LYS A 1 316 ? -6.05202  1.76024   -9.49180  1.000 71.91247  ? 308 LYS A HZ3  1 
ATOM   4562 N  N    . ASN A 1 317 ? -3.92998  -3.39055  -5.07642  1.000 35.84708  ? 309 ASN A N    1 
ATOM   4563 C  CA   . ASN A 1 317 ? -4.62040  -3.84520  -3.86972  1.000 38.63434  ? 309 ASN A CA   1 
ATOM   4564 C  C    . ASN A 1 317 ? -4.12513  -5.25220  -3.54519  1.000 34.04654  ? 309 ASN A C    1 
ATOM   4565 O  O    . ASN A 1 317 ? -4.59370  -6.23410  -4.13112  1.000 30.51918  ? 309 ASN A O    1 
ATOM   4566 C  CB   . ASN A 1 317 ? -6.13547  -3.81455  -4.07207  1.000 47.06729  ? 309 ASN A CB   1 
ATOM   4567 C  CG   . ASN A 1 317 ? -6.90966  -4.09642  -2.79014  1.000 49.85206  ? 309 ASN A CG   1 
ATOM   4568 O  OD1  . ASN A 1 317 ? -6.51046  -4.93233  -1.96937  1.000 39.56429  ? 309 ASN A OD1  1 
ATOM   4569 N  ND2  . ASN A 1 317 ? -8.03529  -3.40694  -2.62225  1.000 39.88698  ? 309 ASN A ND2  1 
ATOM   4570 H  H    . ASN A 1 317 ? -4.11166  -3.87194  -5.76552  1.000 42.99331  ? 309 ASN A H    1 
ATOM   4571 H  HA   . ASN A 1 317 ? -4.39532  -3.26472  -3.12590  1.000 46.33802  ? 309 ASN A HA   1 
ATOM   4572 H  HB2  . ASN A 1 317 ? -6.39370  -2.93556  -4.39079  1.000 56.45755  ? 309 ASN A HB2  1 
ATOM   4573 H  HB3  . ASN A 1 317 ? -6.38057  -4.48923  -4.72448  1.000 56.45755  ? 309 ASN A HB3  1 
ATOM   4574 H  HD21 . ASN A 1 317 ? -8.51166  -3.52667  -1.91632  1.000 47.84119  ? 309 ASN A HD21 1 
ATOM   4575 H  HD22 . ASN A 1 317 ? -8.28642  -2.84160  -3.21968  1.000 47.84119  ? 309 ASN A HD22 1 
ATOM   4576 N  N    . LEU A 1 318 ? -3.17438  -5.34982  -2.61084  1.000 29.69863  ? 310 LEU A N    1 
ATOM   4577 C  CA   . LEU A 1 318 ? -2.55550  -6.63710  -2.31184  1.000 39.68100  ? 310 LEU A CA   1 
ATOM   4578 C  C    . LEU A 1 318 ? -3.50792  -7.59223  -1.60544  1.000 30.32059  ? 310 LEU A C    1 
ATOM   4579 O  O    . LEU A 1 318 ? -3.21898  -8.79059  -1.52473  1.000 27.30866  ? 310 LEU A O    1 
ATOM   4580 C  CB   . LEU A 1 318 ? -1.29781  -6.42881  -1.46438  1.000 35.48503  ? 310 LEU A CB   1 
ATOM   4581 C  CG   . LEU A 1 318 ? -0.12217  -5.81181  -2.23409  1.000 34.89827  ? 310 LEU A CG   1 
ATOM   4582 C  CD1  . LEU A 1 318 ? 0.90962   -5.19757  -1.28820  1.000 30.72422  ? 310 LEU A CD1  1 
ATOM   4583 C  CD2  . LEU A 1 318 ? 0.51795   -6.87651  -3.13145  1.000 32.47732  ? 310 LEU A CD2  1 
ATOM   4584 H  H    . LEU A 1 318 ? -2.87569  -4.69258  -2.14348  1.000 35.61517  ? 310 LEU A H    1 
ATOM   4585 H  HA   . LEU A 1 318 ? -2.28894  -7.05340  -3.14643  1.000 47.59401  ? 310 LEU A HA   1 
ATOM   4586 H  HB2  . LEU A 1 318 ? -1.51420  -5.83470  -0.72878  1.000 42.55885  ? 310 LEU A HB2  1 
ATOM   4587 H  HB3  . LEU A 1 318 ? -1.00839  -7.28899  -1.12200  1.000 42.55885  ? 310 LEU A HB3  1 
ATOM   4588 H  HG   . LEU A 1 318 ? -0.45152  -5.08972  -2.79178  1.000 41.85474  ? 310 LEU A HG   1 
ATOM   4589 H  HD11 . LEU A 1 318 ? 1.62851   -4.81156  -1.81270  1.000 36.84587  ? 310 LEU A HD11 1 
ATOM   4590 H  HD12 . LEU A 1 318 ? 0.48054   -4.50838  -0.75735  1.000 36.84587  ? 310 LEU A HD12 1 
ATOM   4591 H  HD13 . LEU A 1 318 ? 1.25931   -5.89208  -0.70831  1.000 36.84587  ? 310 LEU A HD13 1 
ATOM   4592 H  HD21 . LEU A 1 318 ? 1.26415   -6.48059  -3.60824  1.000 38.94959  ? 310 LEU A HD21 1 
ATOM   4593 H  HD22 . LEU A 1 318 ? 0.83035   -7.60950  -2.57825  1.000 38.94959  ? 310 LEU A HD22 1 
ATOM   4594 H  HD23 . LEU A 1 318 ? -0.14493  -7.19764  -3.76261  1.000 38.94959  ? 310 LEU A HD23 1 
ATOM   4595 N  N    . ILE A 1 319 ? -4.62150  -7.09203  -1.07933  1.000 39.00910  ? 311 ILE A N    1 
ATOM   4596 C  CA   . ILE A 1 319 ? -5.64191  -7.97613  -0.53530  1.000 42.21125  ? 311 ILE A CA   1 
ATOM   4597 C  C    . ILE A 1 319 ? -6.44502  -8.60192  -1.66477  1.000 36.48593  ? 311 ILE A C    1 
ATOM   4598 O  O    . ILE A 1 319 ? -6.70322  -9.81098  -1.67365  1.000 40.60026  ? 311 ILE A O    1 
ATOM   4599 C  CB   . ILE A 1 319 ? -6.55362  -7.20222  0.43431   1.000 42.87558  ? 311 ILE A CB   1 
ATOM   4600 C  CG1  . ILE A 1 319 ? -5.89898  -7.03968  1.80819   1.000 37.99984  ? 311 ILE A CG1  1 
ATOM   4601 C  CG2  . ILE A 1 319 ? -7.89718  -7.92224  0.58301   1.000 43.80703  ? 311 ILE A CG2  1 
ATOM   4602 C  CD1  . ILE A 1 319 ? -4.46725  -6.53074  1.76223   1.000 48.21354  ? 311 ILE A CD1  1 
ATOM   4603 H  H    . ILE A 1 319 ? -4.80740  -6.25404  -1.02632  1.000 46.78773  ? 311 ILE A H    1 
ATOM   4604 H  HA   . ILE A 1 319 ? -5.20806  -8.68607  -0.03665  1.000 50.63031  ? 311 ILE A HA   1 
ATOM   4605 H  HB   . ILE A 1 319 ? -6.69662  -6.31873  0.06029   1.000 51.42750  ? 311 ILE A HB   1 
ATOM   4606 H  HG12 . ILE A 1 319 ? -6.41951  -6.40613  2.32643   1.000 45.57662  ? 311 ILE A HG12 1 
ATOM   4607 H  HG13 . ILE A 1 319 ? -5.88998  -7.90258  2.25116   1.000 45.57662  ? 311 ILE A HG13 1 
ATOM   4608 H  HG21 . ILE A 1 319 ? -8.40337  -7.50219  1.29591   1.000 52.54525  ? 311 ILE A HG21 1 
ATOM   4609 H  HG22 . ILE A 1 319 ? -8.38519  -7.85593  -0.25266  1.000 52.54525  ? 311 ILE A HG22 1 
ATOM   4610 H  HG23 . ILE A 1 319 ? -7.73407  -8.85400  0.79777   1.000 52.54525  ? 311 ILE A HG23 1 
ATOM   4611 H  HD11 . ILE A 1 319 ? -4.17529  -6.32729  2.66459   1.000 57.83306  ? 311 ILE A HD11 1 
ATOM   4612 H  HD12 . ILE A 1 319 ? -3.90014  -7.21753  1.37802   1.000 57.83306  ? 311 ILE A HD12 1 
ATOM   4613 H  HD13 . ILE A 1 319 ? -4.43404  -5.73024  1.21542   1.000 57.83306  ? 311 ILE A HD13 1 
ATOM   4614 N  N    . THR A 1 320 ? -6.84297  -7.77894  -2.63675  1.000 31.02270  ? 312 THR A N    1 
ATOM   4615 C  CA   . THR A 1 320 ? -7.65924  -8.23832  -3.75553  1.000 36.04191  ? 312 THR A CA   1 
ATOM   4616 C  C    . THR A 1 320 ? -6.81722  -8.88001  -4.85256  1.000 41.18241  ? 312 THR A C    1 
ATOM   4617 O  O    . THR A 1 320 ? -7.22254  -9.88812  -5.44514  1.000 39.87873  ? 312 THR A O    1 
ATOM   4618 C  CB   . THR A 1 320 ? -8.44414  -7.05701  -4.33760  1.000 39.97786  ? 312 THR A CB   1 
ATOM   4619 O  OG1  . THR A 1 320 ? -9.30718  -6.50753  -3.33270  1.000 51.92086  ? 312 THR A OG1  1 
ATOM   4620 C  CG2  . THR A 1 320 ? -9.26478  -7.48559  -5.55007  1.000 53.20326  ? 312 THR A CG2  1 
ATOM   4621 H  H    . THR A 1 320 ? -6.65100  -6.94134  -2.67087  1.000 37.20406  ? 312 THR A H    1 
ATOM   4622 H  HA   . THR A 1 320 ? -8.28351  -8.90391  -3.42665  1.000 43.22710  ? 312 THR A HA   1 
ATOM   4623 H  HB   . THR A 1 320 ? -7.82122  -6.37400  -4.63147  1.000 47.95024  ? 312 THR A HB   1 
ATOM   4624 H  HG1  . THR A 1 320 ? -9.61038  -5.76694  -3.58806  1.000 62.28185  ? 312 THR A HG1  1 
ATOM   4625 H  HG21 . THR A 1 320 ? -9.75378  -6.72667  -5.90478  1.000 63.82072  ? 312 THR A HG21 1 
ATOM   4626 H  HG22 . THR A 1 320 ? -8.67931  -7.83353  -6.24077  1.000 63.82072  ? 312 THR A HG22 1 
ATOM   4627 H  HG23 . THR A 1 320 ? -9.89666  -8.17619  -5.29570  1.000 63.82072  ? 312 THR A HG23 1 
ATOM   4628 N  N    . GLY A 1 321 ? -5.64859  -8.31243  -5.13037  1.000 40.50696  ? 313 GLY A N    1 
ATOM   4629 C  CA   . GLY A 1 321 ? -4.95136  -8.56784  -6.36838  1.000 33.09266  ? 313 GLY A CA   1 
ATOM   4630 C  C    . GLY A 1 321 ? -5.35692  -7.63074  -7.47947  1.000 29.18783  ? 313 GLY A C    1 
ATOM   4631 O  O    . GLY A 1 321 ? -4.90516  -7.80434  -8.61744  1.000 34.46727  ? 313 GLY A O    1 
ATOM   4632 H  H    . GLY A 1 321 ? -5.23870  -7.76847  -4.60530  1.000 48.58516  ? 313 GLY A H    1 
ATOM   4633 H  HA2  . GLY A 1 321 ? -3.99751  -8.47001  -6.22174  1.000 39.68800  ? 313 GLY A HA2  1 
ATOM   4634 H  HA3  . GLY A 1 321 ? -5.13530  -9.47610  -6.65497  1.000 39.68800  ? 313 GLY A HA3  1 
ATOM   4635 N  N    . GLU A 1 322 ? -6.20045  -6.64560  -7.18336  1.000 36.85252  ? 314 GLU A N    1 
ATOM   4636 C  CA   . GLU A 1 322 ? -6.56973  -5.63995  -8.16849  1.000 41.95904  ? 314 GLU A CA   1 
ATOM   4637 C  C    . GLU A 1 322 ? -5.33337  -4.89663  -8.66065  1.000 30.07377  ? 314 GLU A C    1 
ATOM   4638 O  O    . GLU A 1 322 ? -4.50974  -4.43052  -7.86823  1.000 26.35815  ? 314 GLU A O    1 
ATOM   4639 C  CB   . GLU A 1 322 ? -7.57407  -4.65894  -7.55898  1.000 45.05629  ? 314 GLU A CB   1 
ATOM   4640 C  CG   . GLU A 1 322 ? -8.41054  -3.91199  -8.58137  1.000 53.17480  ? 314 GLU A CG   1 
ATOM   4641 C  CD   . GLU A 1 322 ? -9.11621  -2.70214  -7.99188  1.000 63.11539  ? 314 GLU A CD   1 
ATOM   4642 O  OE1  . GLU A 1 322 ? -10.05444 -2.89321  -7.18579  1.000 68.21385  ? 314 GLU A OE1  1 
ATOM   4643 O  OE2  . GLU A 1 322 ? -8.73064  -1.56144  -8.33335  1.000 68.03507  ? 314 GLU A OE2  1 
ATOM   4644 H  H    . GLU A 1 322 ? -6.57338  -6.53803  -6.41593  1.000 44.19983  ? 314 GLU A H    1 
ATOM   4645 H  HA   . GLU A 1 322 ? -6.98714  -6.07110  -8.93058  1.000 50.32765  ? 314 GLU A HA   1 
ATOM   4646 H  HB2  . GLU A 1 322 ? -8.18120  -5.15253  -6.98570  1.000 54.04436  ? 314 GLU A HB2  1 
ATOM   4647 H  HB3  . GLU A 1 322 ? -7.08790  -4.00043  -7.03848  1.000 54.04436  ? 314 GLU A HB3  1 
ATOM   4648 H  HG2  . GLU A 1 322 ? -7.83345  -3.60338  -9.29734  1.000 63.78657  ? 314 GLU A HG2  1 
ATOM   4649 H  HG3  . GLU A 1 322 ? -9.08668  -4.51088  -8.93502  1.000 63.78657  ? 314 GLU A HG3  1 
ATOM   4650 N  N    . ARG A 1 323 ? -5.21128  -4.77908  -9.97472  1.000 29.24474  ? 315 ARG A N    1 
ATOM   4651 C  CA   . ARG A 1 323 ? -4.05091  -4.16272  -10.59330 1.000 32.92583  ? 315 ARG A CA   1 
ATOM   4652 C  C    . ARG A 1 323 ? -4.35391  -2.73289  -11.01124 1.000 32.53053  ? 315 ARG A C    1 
ATOM   4653 O  O    . ARG A 1 323 ? -5.49379  -2.38152  -11.32703 1.000 40.21628  ? 315 ARG A O    1 
ATOM   4654 C  CB   . ARG A 1 323 ? -3.59959  -4.97546  -11.80601 1.000 24.96426  ? 315 ARG A CB   1 
ATOM   4655 C  CG   . ARG A 1 323 ? -3.13873  -6.35888  -11.42248 1.000 26.09032  ? 315 ARG A CG   1 
ATOM   4656 C  CD   . ARG A 1 323 ? -2.73751  -7.20188  -12.61913 1.000 29.92767  ? 315 ARG A CD   1 
ATOM   4657 N  NE   . ARG A 1 323 ? -2.08061  -8.42715  -12.17824 1.000 24.99342  ? 315 ARG A NE   1 
ATOM   4658 C  CZ   . ARG A 1 323 ? -0.83483  -8.48013  -11.70940 1.000 32.93698  ? 315 ARG A CZ   1 
ATOM   4659 N  NH1  . ARG A 1 323 ? -0.09478  -7.37604  -11.62643 1.000 24.79819  ? 315 ARG A NH1  1 
ATOM   4660 N  NH2  . ARG A 1 323 ? -0.32001  -9.63970  -11.32046 1.000 32.11448  ? 315 ARG A NH2  1 
ATOM   4661 H  H    . ARG A 1 323 ? -5.79933  -5.05440  -10.53863 1.000 35.07050  ? 315 ARG A H    1 
ATOM   4662 H  HA   . ARG A 1 323 ? -3.32370  -4.13285  -9.95207  1.000 39.48781  ? 315 ARG A HA   1 
ATOM   4663 H  HB2  . ARG A 1 323 ? -4.34202  -5.06376  -12.42399 1.000 29.93392  ? 315 ARG A HB2  1 
ATOM   4664 H  HB3  . ARG A 1 323 ? -2.86087  -4.51878  -12.23802 1.000 29.93392  ? 315 ARG A HB3  1 
ATOM   4665 H  HG2  . ARG A 1 323 ? -2.36832  -6.28430  -10.83783 1.000 31.28520  ? 315 ARG A HG2  1 
ATOM   4666 H  HG3  . ARG A 1 323 ? -3.86053  -6.81622  -10.96342 1.000 31.28520  ? 315 ARG A HG3  1 
ATOM   4667 H  HD2  . ARG A 1 323 ? -3.52748  -7.43993  -13.12922 1.000 35.89002  ? 315 ARG A HD2  1 
ATOM   4668 H  HD3  . ARG A 1 323 ? -2.12047  -6.70273  -13.17681 1.000 35.89002  ? 315 ARG A HD3  1 
ATOM   4669 H  HE   . ARG A 1 323 ? -2.52554  -9.16170  -12.22382 1.000 29.96892  ? 315 ARG A HE   1 
ATOM   4670 H  HH11 . ARG A 1 323 ? -0.42030  -6.62038  -11.87667 1.000 29.73464  ? 315 ARG A HH11 1 
ATOM   4671 H  HH12 . ARG A 1 323 ? 0.70863   -7.41871  -11.32260 1.000 29.73464  ? 315 ARG A HH12 1 
ATOM   4672 H  HH21 . ARG A 1 323 ? -0.79068  -10.35770 -11.37098 1.000 38.51419  ? 315 ARG A HH21 1 
ATOM   4673 H  HH22 . ARG A 1 323 ? 0.48431   -9.67321  -11.01788 1.000 38.51419  ? 315 ARG A HH22 1 
ATOM   4674 N  N    . TYR A 1 324 ? -3.31069  -1.90762  -10.99925 1.000 33.99719  ? 316 TYR A N    1 
ATOM   4675 C  CA   . TYR A 1 324 ? -3.42648  -0.54941  -11.50533 1.000 40.87545  ? 316 TYR A CA   1 
ATOM   4676 C  C    . TYR A 1 324 ? -4.11459  -0.55811  -12.86363 1.000 38.08589  ? 316 TYR A C    1 
ATOM   4677 O  O    . TYR A 1 324 ? -3.87786  -1.44693  -13.68270 1.000 31.00236  ? 316 TYR A O    1 
ATOM   4678 C  CB   . TYR A 1 324 ? -2.04333  0.08693   -11.63715 1.000 31.07309  ? 316 TYR A CB   1 
ATOM   4679 C  CG   . TYR A 1 324 ? -1.46093  0.59124   -10.34779 1.000 34.75946  ? 316 TYR A CG   1 
ATOM   4680 C  CD1  . TYR A 1 324 ? -1.68328  1.88539   -9.92611  1.000 35.27001  ? 316 TYR A CD1  1 
ATOM   4681 C  CD2  . TYR A 1 324 ? -0.67895  -0.22605  -9.55398  1.000 33.71428  ? 316 TYR A CD2  1 
ATOM   4682 C  CE1  . TYR A 1 324 ? -1.13937  2.35020   -8.74382  1.000 33.67555  ? 316 TYR A CE1  1 
ATOM   4683 C  CE2  . TYR A 1 324 ? -0.13233  0.23269   -8.37381  1.000 30.11726  ? 316 TYR A CE2  1 
ATOM   4684 C  CZ   . TYR A 1 324 ? -0.36591  1.51830   -7.97591  1.000 26.73218  ? 316 TYR A CZ   1 
ATOM   4685 O  OH   . TYR A 1 324 ? 0.17140   1.97137   -6.79858  1.000 30.70811  ? 316 TYR A OH   1 
ATOM   4686 H  H    . TYR A 1 324 ? -2.52897  -2.11113  -10.70411 1.000 40.77343  ? 316 TYR A H    1 
ATOM   4687 H  HA   . TYR A 1 324 ? -3.94925  -0.01711  -10.88543 1.000 49.02735  ? 316 TYR A HA   1 
ATOM   4688 H  HB2  . TYR A 1 324 ? -1.43177  -0.57562  -11.99481 1.000 37.26452  ? 316 TYR A HB2  1 
ATOM   4689 H  HB3  . TYR A 1 324 ? -2.10729  0.84110   -12.24381 1.000 37.26452  ? 316 TYR A HB3  1 
ATOM   4690 H  HD1  . TYR A 1 324 ? -2.20651  2.45312   -10.44459 1.000 42.30083  ? 316 TYR A HD1  1 
ATOM   4691 H  HD2  . TYR A 1 324 ? -0.51817  -1.10235  -9.82073  1.000 40.43394  ? 316 TYR A HD2  1 
ATOM   4692 H  HE1  . TYR A 1 324 ? -1.29749  3.22474   -8.46981  1.000 40.38747  ? 316 TYR A HE1  1 
ATOM   4693 H  HE2  . TYR A 1 324 ? 0.39247   -0.33026  -7.85172  1.000 36.11752  ? 316 TYR A HE2  1 
ATOM   4694 H  HH   . TYR A 1 324 ? -0.20757  2.68376   -6.56517  1.000 36.82654  ? 316 TYR A HH   1 
ATOM   4695 N  N    . THR A 1 325 ? -4.96918  0.44303   -13.10127 1.000 44.57851  ? 317 THR A N    1 
ATOM   4696 C  CA   . THR A 1 325 ? -5.56598  0.61847   -14.42267 1.000 37.60531  ? 317 THR A CA   1 
ATOM   4697 C  C    . THR A 1 325 ? -4.61393  1.34413   -15.36364 1.000 38.91229  ? 317 THR A C    1 
ATOM   4698 O  O    . THR A 1 325 ? -4.60195  1.06975   -16.56972 1.000 37.56244  ? 317 THR A O    1 
ATOM   4699 C  CB   . THR A 1 325 ? -6.88369  1.38494   -14.30121 1.000 41.62232  ? 317 THR A CB   1 
ATOM   4700 O  OG1  . THR A 1 325 ? -6.66573  2.59212   -13.56148 1.000 49.37271  ? 317 THR A OG1  1 
ATOM   4701 C  CG2  . THR A 1 325 ? -7.92780  0.53054   -13.57980 1.000 40.97849  ? 317 THR A CG2  1 
ATOM   4702 H  H    . THR A 1 325 ? -5.21538  1.02629   -12.51922 1.000 53.47102  ? 317 THR A H    1 
ATOM   4703 H  HA   . THR A 1 325 ? -5.76765  -0.24960  -14.80566 1.000 45.10318  ? 317 THR A HA   1 
ATOM   4704 H  HB   . THR A 1 325 ? -7.21980  1.60279   -15.18466 1.000 49.92359  ? 317 THR A HB   1 
ATOM   4705 H  HG1  . THR A 1 325 ? -7.38763  3.01399   -13.48089 1.000 59.22407  ? 317 THR A HG1  1 
ATOM   4706 H  HG21 . THR A 1 325 ? -8.75885  1.02358   -13.49511 1.000 49.15100  ? 317 THR A HG21 1 
ATOM   4707 H  HG22 . THR A 1 325 ? -8.09420  -0.28321  -14.08082 1.000 49.15100  ? 317 THR A HG22 1 
ATOM   4708 H  HG23 . THR A 1 325 ? -7.60960  0.29543   -12.69415 1.000 49.15100  ? 317 THR A HG23 1 
ATOM   4709 N  N    . ASN A 1 326 ? -3.80105  2.23986   -14.82561 1.000 33.85874  ? 318 ASN A N    1 
ATOM   4710 C  CA   . ASN A 1 326 ? -2.77955  2.97252   -15.55584 1.000 38.50579  ? 318 ASN A CA   1 
ATOM   4711 C  C    . ASN A 1 326 ? -1.47696  2.87781   -14.78646 1.000 33.47413  ? 318 ASN A C    1 
ATOM   4712 O  O    . ASN A 1 326 ? -1.47827  2.65664   -13.56749 1.000 29.53470  ? 318 ASN A O    1 
ATOM   4713 C  CB   . ASN A 1 326 ? -3.16759  4.44611   -15.75224 1.000 39.52311  ? 318 ASN A CB   1 
ATOM   4714 C  CG   . ASN A 1 326 ? -4.54877  4.60892   -16.35380 1.000 42.43236  ? 318 ASN A CG   1 
ATOM   4715 O  OD1  . ASN A 1 326 ? -4.76254  4.33925   -17.53540 1.000 45.04949  ? 318 ASN A OD1  1 
ATOM   4716 N  ND2  . ASN A 1 326 ? -5.50070  5.03409   -15.53502 1.000 49.84733  ? 318 ASN A ND2  1 
ATOM   4717 H  H    . ASN A 1 326 ? -3.82416  2.45151   -13.99238 1.000 40.60729  ? 318 ASN A H    1 
ATOM   4718 H  HA   . ASN A 1 326 ? -2.65947  2.58279   -16.43595 1.000 46.18376  ? 318 ASN A HA   1 
ATOM   4719 H  HB2  . ASN A 1 326 ? -3.15995  4.89314   -14.89142 1.000 47.40455  ? 318 ASN A HB2  1 
ATOM   4720 H  HB3  . ASN A 1 326 ? -2.52826  4.86516   -16.34937 1.000 47.40455  ? 318 ASN A HB3  1 
ATOM   4721 H  HD21 . ASN A 1 326 ? -6.30218  5.14300   -15.82720 1.000 59.79360  ? 318 ASN A HD21 1 
ATOM   4722 H  HD22 . ASN A 1 326 ? -5.31678  5.20101   -14.71167 1.000 59.79360  ? 318 ASN A HD22 1 
ATOM   4723 N  N    . PRO A 1 327 ? -0.33868  3.02605   -15.46349 1.000 36.20305  ? 319 PRO A N    1 
ATOM   4724 C  CA   . PRO A 1 327 ? 0.96162   2.89503   -14.78035 1.000 37.96987  ? 319 PRO A CA   1 
ATOM   4725 C  C    . PRO A 1 327 ? 1.00797   3.75114   -13.52717 1.000 30.06129  ? 319 PRO A C    1 
ATOM   4726 O  O    . PRO A 1 327 ? 0.50399   4.88399   -13.52533 1.000 37.45413  ? 319 PRO A O    1 
ATOM   4727 C  CB   . PRO A 1 327 ? 1.97161   3.38780   -15.82663 1.000 39.12430  ? 319 PRO A CB   1 
ATOM   4728 C  CG   . PRO A 1 327 ? 1.29903   3.12106   -17.16249 1.000 36.08043  ? 319 PRO A CG   1 
ATOM   4729 C  CD   . PRO A 1 327 ? -0.19470  3.29936   -16.91060 1.000 41.19444  ? 319 PRO A CD   1 
ATOM   4730 H  HA   . PRO A 1 327 ? 1.14323   1.96850   -14.55796 1.000 45.54065  ? 319 PRO A HA   1 
ATOM   4731 H  HB2  . PRO A 1 327 ? 2.14064   4.33510   -15.70433 1.000 46.92597  ? 319 PRO A HB2  1 
ATOM   4732 H  HB3  . PRO A 1 327 ? 2.80044   2.89005   -15.74799 1.000 46.92597  ? 319 PRO A HB3  1 
ATOM   4733 H  HG2  . PRO A 1 327 ? 1.61568   3.75746   -17.82252 1.000 43.27332  ? 319 PRO A HG2  1 
ATOM   4734 H  HG3  . PRO A 1 327 ? 1.49396   2.21653   -17.45356 1.000 43.27332  ? 319 PRO A HG3  1 
ATOM   4735 H  HD2  . PRO A 1 327 ? -0.47309  4.20487   -17.11908 1.000 49.41014  ? 319 PRO A HD2  1 
ATOM   4736 H  HD3  . PRO A 1 327 ? -0.70988  2.66522   -17.43343 1.000 49.41014  ? 319 PRO A HD3  1 
ATOM   4737 N  N    . PRO A 1 328 ? 1.58578   3.24201   -12.44011 1.000 31.86916  ? 320 PRO A N    1 
ATOM   4738 C  CA   . PRO A 1 328 ? 1.78211   4.08188   -11.25332 1.000 32.40072  ? 320 PRO A CA   1 
ATOM   4739 C  C    . PRO A 1 328 ? 2.47413   5.39328   -11.60317 1.000 36.98895  ? 320 PRO A C    1 
ATOM   4740 O  O    . PRO A 1 328 ? 3.40402   5.43577   -12.41390 1.000 26.58641  ? 320 PRO A O    1 
ATOM   4741 C  CB   . PRO A 1 328 ? 2.65496   3.21304   -10.34190 1.000 33.55060  ? 320 PRO A CB   1 
ATOM   4742 C  CG   . PRO A 1 328 ? 2.37780   1.81781   -10.75627 1.000 36.63183  ? 320 PRO A CG   1 
ATOM   4743 C  CD   . PRO A 1 328 ? 2.02172   1.85102   -12.22123 1.000 31.82481  ? 320 PRO A CD   1 
ATOM   4744 H  HA   . PRO A 1 328 ? 0.93250   4.26433   -10.82230 1.000 38.85767  ? 320 PRO A HA   1 
ATOM   4745 H  HB2  . PRO A 1 328 ? 3.59030   3.43421   -10.47276 1.000 40.23753  ? 320 PRO A HB2  1 
ATOM   4746 H  HB3  . PRO A 1 328 ? 2.40700   3.35511   -9.41495  1.000 40.23753  ? 320 PRO A HB3  1 
ATOM   4747 H  HG2  . PRO A 1 328 ? 3.16947   1.27610   -10.61233 1.000 43.93501  ? 320 PRO A HG2  1 
ATOM   4748 H  HG3  . PRO A 1 328 ? 1.63764   1.46851   -10.23563 1.000 43.93501  ? 320 PRO A HG3  1 
ATOM   4749 H  HD2  . PRO A 1 328 ? 2.79523   1.64270   -12.76820 1.000 38.16659  ? 320 PRO A HD2  1 
ATOM   4750 H  HD3  . PRO A 1 328 ? 1.30182   1.23031   -12.41455 1.000 38.16659  ? 320 PRO A HD3  1 
ATOM   4751 N  N    . LYS A 1 329 ? 2.02094   6.46731   -10.96225 1.000 30.67066  ? 321 LYS A N    1 
ATOM   4752 C  CA   . LYS A 1 329 ? 2.60743   7.78875   -11.14961 1.000 30.93469  ? 321 LYS A CA   1 
ATOM   4753 C  C    . LYS A 1 329 ? 3.86929   7.85501   -10.30477 1.000 31.26320  ? 321 LYS A C    1 
ATOM   4754 O  O    . LYS A 1 329 ? 3.81387   8.09178   -9.09280  1.000 35.54049  ? 321 LYS A O    1 
ATOM   4755 C  CB   . LYS A 1 329 ? 1.61872   8.88279   -10.76855 1.000 36.71601  ? 321 LYS A CB   1 
ATOM   4756 C  CG   . LYS A 1 329 ? 0.21312   8.67630   -11.31396 1.000 42.69682  ? 321 LYS A CG   1 
ATOM   4757 C  CD   . LYS A 1 329 ? -0.00704  9.48633   -12.58459 1.000 45.49007  ? 321 LYS A CD   1 
ATOM   4758 C  CE   . LYS A 1 329 ? -1.47656  9.49688   -12.98894 1.000 54.02497  ? 321 LYS A CE   1 
ATOM   4759 N  NZ   . LYS A 1 329 ? -1.73541  8.61559   -14.19069 1.000 57.78739  ? 321 LYS A NZ   1 
ATOM   4760 H  H    . LYS A 1 329 ? 1.36530   6.45512   -10.40586 1.000 36.78160  ? 321 LYS A H    1 
ATOM   4761 H  HA   . LYS A 1 329 ? 2.84318   7.91631   -12.08184 1.000 37.09844  ? 321 LYS A HA   1 
ATOM   4762 H  HB2  . LYS A 1 329 ? 1.55580   8.91983   -9.80130  1.000 44.03602  ? 321 LYS A HB2  1 
ATOM   4763 H  HB3  . LYS A 1 329 ? 1.94568   9.72883   -11.11238 1.000 44.03602  ? 321 LYS A HB3  1 
ATOM   4764 H  HG2  . LYS A 1 329 ? 0.08237   7.73799   -11.52223 1.000 51.21299  ? 321 LYS A HG2  1 
ATOM   4765 H  HG3  . LYS A 1 329 ? -0.43529  8.96265   -10.65180 1.000 51.21299  ? 321 LYS A HG3  1 
ATOM   4766 H  HD2  . LYS A 1 329 ? 0.27518   10.40227  -12.43524 1.000 54.56490  ? 321 LYS A HD2  1 
ATOM   4767 H  HD3  . LYS A 1 329 ? 0.50615   9.09493   -13.30870 1.000 54.56490  ? 321 LYS A HD3  1 
ATOM   4768 H  HE2  . LYS A 1 329 ? -2.01382  9.16927   -12.25075 1.000 64.80677  ? 321 LYS A HE2  1 
ATOM   4769 H  HE3  . LYS A 1 329 ? -1.73980  10.40284  -13.21441 1.000 64.80677  ? 321 LYS A HE3  1 
ATOM   4770 H  HZ1  . LYS A 1 329 ? -2.60009  8.63352   -14.40072 1.000 69.32167  ? 321 LYS A HZ1  1 
ATOM   4771 H  HZ2  . LYS A 1 329 ? -1.26290  8.90441   -14.88740 1.000 69.32167  ? 321 LYS A HZ2  1 
ATOM   4772 H  HZ3  . LYS A 1 329 ? -1.49953  7.77677   -14.00948 1.000 69.32167  ? 321 LYS A HZ3  1 
ATOM   4773 N  N    . LEU A 1 330 ? 5.02050   7.65325   -10.94760 1.000 31.57042  ? 322 LEU A N    1 
ATOM   4774 C  CA   . LEU A 1 330 ? 6.29668   7.66608   -10.25065 1.000 30.23864  ? 322 LEU A CA   1 
ATOM   4775 C  C    . LEU A 1 330 ? 7.02411   9.00039   -10.36443 1.000 33.75212  ? 322 LEU A C    1 
ATOM   4776 O  O    . LEU A 1 330 ? 8.01365   9.21199   -9.65382  1.000 29.84988  ? 322 LEU A O    1 
ATOM   4777 C  CB   . LEU A 1 330 ? 7.19760   6.54496   -10.78262 1.000 30.34593  ? 322 LEU A CB   1 
ATOM   4778 C  CG   . LEU A 1 330 ? 6.62496   5.12827   -10.76374 1.000 24.93211  ? 322 LEU A CG   1 
ATOM   4779 C  CD1  . LEU A 1 330 ? 7.65845   4.13437   -11.26606 1.000 29.52825  ? 322 LEU A CD1  1 
ATOM   4780 C  CD2  . LEU A 1 330 ? 6.17394   4.75300   -9.35021  1.000 30.25538  ? 322 LEU A CD2  1 
ATOM   4781 H  H    . LEU A 1 330 ? 5.08373   7.50633   -11.79259 1.000 37.86131  ? 322 LEU A H    1 
ATOM   4782 H  HA   . LEU A 1 330 ? 6.14016   7.49697   -9.30842  1.000 36.26318  ? 322 LEU A HA   1 
ATOM   4783 H  HB2  . LEU A 1 330 ? 7.41592   6.74974   -11.70528 1.000 36.39193  ? 322 LEU A HB2  1 
ATOM   4784 H  HB3  . LEU A 1 330 ? 8.00540   6.53092   -10.24581 1.000 36.39193  ? 322 LEU A HB3  1 
ATOM   4785 H  HG   . LEU A 1 330 ? 5.85316   5.09079   -11.35009 1.000 29.89534  ? 322 LEU A HG   1 
ATOM   4786 H  HD11 . LEU A 1 330 ? 7.28296   3.24090   -11.22591 1.000 35.41071  ? 322 LEU A HD11 1 
ATOM   4787 H  HD12 . LEU A 1 330 ? 7.88986   4.35508   -12.18183 1.000 35.41071  ? 322 LEU A HD12 1 
ATOM   4788 H  HD13 . LEU A 1 330 ? 8.44700   4.18735   -10.70366 1.000 35.41071  ? 322 LEU A HD13 1 
ATOM   4789 H  HD21 . LEU A 1 330 ? 5.87952   3.82877   -9.34760  1.000 36.28327  ? 322 LEU A HD21 1 
ATOM   4790 H  HD22 . LEU A 1 330 ? 6.92026   4.86413   -8.74065  1.000 36.28327  ? 322 LEU A HD22 1 
ATOM   4791 H  HD23 . LEU A 1 330 ? 5.44286   5.33380   -9.08736  1.000 36.28327  ? 322 LEU A HD23 1 
ATOM   4792 N  N    . LYS A 1 331 ? 6.55529   9.90006   -11.22347 1.000 28.91149  ? 323 LYS A N    1 
ATOM   4793 C  CA   . LYS A 1 331 ? 7.23179   11.16956  -11.44142 1.000 32.05193  ? 323 LYS A CA   1 
ATOM   4794 C  C    . LYS A 1 331 ? 7.32582   11.95487  -10.14103 1.000 24.66893  ? 323 LYS A C    1 
ATOM   4795 O  O    . LYS A 1 331 ? 6.31149   12.23810  -9.49405  1.000 25.48650  ? 323 LYS A O    1 
ATOM   4796 C  CB   . LYS A 1 331 ? 6.48393   11.97268  -12.50312 1.000 27.78842  ? 323 LYS A CB   1 
ATOM   4797 C  CG   . LYS A 1 331 ? 6.97277   13.38834  -12.67788 1.000 37.21409  ? 323 LYS A CG   1 
ATOM   4798 C  CD   . LYS A 1 331 ? 8.37900   13.43167  -13.23780 1.000 41.07994  ? 323 LYS A CD   1 
ATOM   4799 C  CE   . LYS A 1 331 ? 8.54384   14.60938  -14.21852 1.000 46.03081  ? 323 LYS A CE   1 
ATOM   4800 N  NZ   . LYS A 1 331 ? 9.95489   14.75496  -14.67585 1.000 50.49328  ? 323 LYS A NZ   1 
ATOM   4801 H  H    . LYS A 1 331 ? 5.84309   9.79760   -11.69450 1.000 34.67060  ? 323 LYS A H    1 
ATOM   4802 H  HA   . LYS A 1 331 ? 8.13368   11.00473  -11.75816 1.000 38.43912  ? 323 LYS A HA   1 
ATOM   4803 H  HB2  . LYS A 1 331 ? 6.58120   11.52196  -13.35652 1.000 33.32292  ? 323 LYS A HB2  1 
ATOM   4804 H  HB3  . LYS A 1 331 ? 5.54712   12.01500  -12.25515 1.000 33.32292  ? 323 LYS A HB3  1 
ATOM   4805 H  HG2  . LYS A 1 331 ? 6.38640   13.85604  -13.29296 1.000 44.63372  ? 323 LYS A HG2  1 
ATOM   4806 H  HG3  . LYS A 1 331 ? 6.97477   13.83509  -11.81689 1.000 44.63372  ? 323 LYS A HG3  1 
ATOM   4807 H  HD2  . LYS A 1 331 ? 9.01289   13.54468  -12.51233 1.000 49.27273  ? 323 LYS A HD2  1 
ATOM   4808 H  HD3  . LYS A 1 331 ? 8.56332   12.60694  -13.71398 1.000 49.27273  ? 323 LYS A HD3  1 
ATOM   4809 H  HE2  . LYS A 1 331 ? 7.98609   14.45765  -14.99749 1.000 55.21379  ? 323 LYS A HE2  1 
ATOM   4810 H  HE3  . LYS A 1 331 ? 8.28094   15.43234  -13.77747 1.000 55.21379  ? 323 LYS A HE3  1 
ATOM   4811 H  HZ1  . LYS A 1 331 ? 10.02154  15.43537  -15.24567 1.000 60.56875  ? 323 LYS A HZ1  1 
ATOM   4812 H  HZ2  . LYS A 1 331 ? 10.48646  14.90883  -13.97881 1.000 60.56875  ? 323 LYS A HZ2  1 
ATOM   4813 H  HZ3  . LYS A 1 331 ? 10.22124  14.00986  -15.08327 1.000 60.56875  ? 323 LYS A HZ3  1 
ATOM   4814 N  N    . GLY A 1 332 ? 8.54926   12.32627  -9.77611  1.000 28.08531  ? 324 GLY A N    1 
ATOM   4815 C  CA   . GLY A 1 332 ? 8.77307   13.11121  -8.57826  1.000 33.96576  ? 324 GLY A CA   1 
ATOM   4816 C  C    . GLY A 1 332 ? 8.52187   12.39800  -7.26594  1.000 39.19734  ? 324 GLY A C    1 
ATOM   4817 O  O    . GLY A 1 332 ? 8.45286   13.05750  -6.22185  1.000 31.58989  ? 324 GLY A O    1 
ATOM   4818 H  H    . GLY A 1 332 ? 9.26647   12.13349  -10.20976 1.000 33.67918  ? 324 GLY A H    1 
ATOM   4819 H  HA2  . GLY A 1 332 ? 9.69571   13.41059  -8.57562  1.000 40.73572  ? 324 GLY A HA2  1 
ATOM   4820 H  HA3  . GLY A 1 332 ? 8.18981   13.88577  -8.60563  1.000 40.73572  ? 324 GLY A HA3  1 
ATOM   4821 N  N    . LYS A 1 333 ? 8.39068   11.07590  -7.27437  1.000 33.53435  ? 325 LYS A N    1 
ATOM   4822 C  CA   . LYS A 1 333 ? 8.11059   10.31646  -6.06462  1.000 29.84786  ? 325 LYS A CA   1 
ATOM   4823 C  C    . LYS A 1 333 ? 9.37580   9.62814   -5.56784  1.000 31.23762  ? 325 LYS A C    1 
ATOM   4824 O  O    . LYS A 1 333 ? 10.20699  9.18053   -6.36324  1.000 20.76227  ? 325 LYS A O    1 
ATOM   4825 C  CB   . LYS A 1 333 ? 7.02042   9.27490   -6.31872  1.000 30.75099  ? 325 LYS A CB   1 
ATOM   4826 C  CG   . LYS A 1 333 ? 5.72593   9.84367   -6.85858  1.000 34.55038  ? 325 LYS A CG   1 
ATOM   4827 C  CD   . LYS A 1 333 ? 5.10384   10.82217  -5.88905  1.000 36.66437  ? 325 LYS A CD   1 
ATOM   4828 C  CE   . LYS A 1 333 ? 3.75566   11.31992  -6.39719  1.000 48.83331  ? 325 LYS A CE   1 
ATOM   4829 N  NZ   . LYS A 1 333 ? 3.13550   12.31473  -5.46556  1.000 52.76030  ? 325 LYS A NZ   1 
ATOM   4830 H  H    . LYS A 1 333 ? 8.46099   10.59013  -7.98055  1.000 40.21803  ? 325 LYS A H    1 
ATOM   4831 H  HA   . LYS A 1 333 ? 7.80288   10.92108  -5.37133  1.000 35.79424  ? 325 LYS A HA   1 
ATOM   4832 H  HB2  . LYS A 1 333 ? 7.35116   8.63257   -6.96597  1.000 36.87800  ? 325 LYS A HB2  1 
ATOM   4833 H  HB3  . LYS A 1 333 ? 6.81817   8.82833   -5.48171  1.000 36.87800  ? 325 LYS A HB3  1 
ATOM   4834 H  HG2  . LYS A 1 333 ? 5.90210   10.30952  -7.69096  1.000 41.43726  ? 325 LYS A HG2  1 
ATOM   4835 H  HG3  . LYS A 1 333 ? 5.09593   9.12168   -7.00938  1.000 41.43726  ? 325 LYS A HG3  1 
ATOM   4836 H  HD2  . LYS A 1 333 ? 4.96642   10.38553  -5.03386  1.000 43.97405  ? 325 LYS A HD2  1 
ATOM   4837 H  HD3  . LYS A 1 333 ? 5.69129   11.58642  -5.78075  1.000 43.97405  ? 325 LYS A HD3  1 
ATOM   4838 H  HE2  . LYS A 1 333 ? 3.87790   11.74781  -7.25909  1.000 58.57678  ? 325 LYS A HE2  1 
ATOM   4839 H  HE3  . LYS A 1 333 ? 3.14971   10.56739  -6.48335  1.000 58.57678  ? 325 LYS A HE3  1 
ATOM   4840 H  HZ1  . LYS A 1 333 ? 2.35541   12.59229  -5.79197  1.000 63.28917  ? 325 LYS A HZ1  1 
ATOM   4841 H  HZ2  . LYS A 1 333 ? 2.99908   11.94192  -4.66901  1.000 63.28917  ? 325 LYS A HZ2  1 
ATOM   4842 H  HZ3  . LYS A 1 333 ? 3.67378   13.01669  -5.36755  1.000 63.28917  ? 325 LYS A HZ3  1 
ATOM   4843 N  N    . LYS A 1 334 ? 9.50288   9.53875   -4.24488  1.000 31.20621  ? 326 LYS A N    1 
ATOM   4844 C  CA   . LYS A 1 334 ? 10.61205  8.85699   -3.59292  1.000 21.40583  ? 326 LYS A CA   1 
ATOM   4845 C  C    . LYS A 1 334 ? 10.25612  7.39012   -3.41058  1.000 18.75250  ? 326 LYS A C    1 
ATOM   4846 O  O    . LYS A 1 334 ? 9.19669   7.06627   -2.86484  1.000 19.07431  ? 326 LYS A O    1 
ATOM   4847 C  CB   . LYS A 1 334 ? 10.90091  9.50685   -2.24056  1.000 23.33329  ? 326 LYS A CB   1 
ATOM   4848 C  CG   . LYS A 1 334 ? 12.01557  8.87083   -1.44246  1.000 25.75544  ? 326 LYS A CG   1 
ATOM   4849 C  CD   . LYS A 1 334 ? 12.38745  9.78569   -0.25332  1.000 23.11276  ? 326 LYS A CD   1 
ATOM   4850 C  CE   . LYS A 1 334 ? 13.24661  9.07129   0.74460   1.000 20.84317  ? 326 LYS A CE   1 
ATOM   4851 N  NZ   . LYS A 1 334 ? 13.69191  9.97715   1.82174   1.000 26.58568  ? 326 LYS A NZ   1 
ATOM   4852 H  H    . LYS A 1 334 ? 8.94063   9.87634   -3.68855  1.000 37.42426  ? 326 LYS A H    1 
ATOM   4853 H  HA   . LYS A 1 334 ? 11.41205  8.91546   -4.13834  1.000 25.66380  ? 326 LYS A HA   1 
ATOM   4854 H  HB2  . LYS A 1 334 ? 11.14586  10.43302  -2.39259  1.000 27.97676  ? 326 LYS A HB2  1 
ATOM   4855 H  HB3  . LYS A 1 334 ? 10.09604  9.46080   -1.70116  1.000 27.97676  ? 326 LYS A HB3  1 
ATOM   4856 H  HG2  . LYS A 1 334 ? 11.72443  8.01218   -1.09770  1.000 30.88334  ? 326 LYS A HG2  1 
ATOM   4857 H  HG3  . LYS A 1 334 ? 12.79751  8.75477   -2.00460  1.000 30.88334  ? 326 LYS A HG3  1 
ATOM   4858 H  HD2  . LYS A 1 334 ? 12.87806  10.55533  -0.58173  1.000 27.71213  ? 326 LYS A HD2  1 
ATOM   4859 H  HD3  . LYS A 1 334 ? 11.57718  10.07516  0.19452   1.000 27.71213  ? 326 LYS A HD3  1 
ATOM   4860 H  HE2  . LYS A 1 334 ? 12.73988  8.34742   1.14478   1.000 24.98861  ? 326 LYS A HE2  1 
ATOM   4861 H  HE3  . LYS A 1 334 ? 14.03232  8.71895   0.29803   1.000 24.98861  ? 326 LYS A HE3  1 
ATOM   4862 H  HZ1  . LYS A 1 334 ? 13.99468  9.50373   2.51189   1.000 31.87963  ? 326 LYS A HZ1  1 
ATOM   4863 H  HZ2  . LYS A 1 334 ? 14.34420  10.50509  1.52526   1.000 31.87963  ? 326 LYS A HZ2  1 
ATOM   4864 H  HZ3  . LYS A 1 334 ? 13.01232  10.48302  2.09442   1.000 31.87963  ? 326 LYS A HZ3  1 
ATOM   4865 N  N    . ILE A 1 335 ? 11.13883  6.50614   -3.86260  1.000 15.85375  ? 327 ILE A N    1 
ATOM   4866 C  CA   . ILE A 1 335 ? 10.89306  5.07173   -3.82183  1.000 16.66025  ? 327 ILE A CA   1 
ATOM   4867 C  C    . ILE A 1 335 ? 12.09833  4.37466   -3.21143  1.000 19.37324  ? 327 ILE A C    1 
ATOM   4868 O  O    . ILE A 1 335 ? 13.24039  4.63605   -3.60581  1.000 21.94210  ? 327 ILE A O    1 
ATOM   4869 C  CB   . ILE A 1 335 ? 10.59927  4.51740   -5.22670  1.000 24.58831  ? 327 ILE A CB   1 
ATOM   4870 C  CG1  . ILE A 1 335 ? 10.25764  3.03284   -5.15913  1.000 20.71871  ? 327 ILE A CG1  1 
ATOM   4871 C  CG2  . ILE A 1 335 ? 11.80046  4.72951   -6.14916  1.000 26.69497  ? 327 ILE A CG2  1 
ATOM   4872 C  CD1  . ILE A 1 335 ? 9.52908   2.53021   -6.36725  1.000 23.10876  ? 327 ILE A CD1  1 
ATOM   4873 H  H    . ILE A 1 335 ? 11.89964  6.71824   -4.20288  1.000 19.00131  ? 327 ILE A H    1 
ATOM   4874 H  HA   . ILE A 1 335 ? 10.13192  4.89474   -3.24717  1.000 19.96911  ? 327 ILE A HA   1 
ATOM   4875 H  HB   . ILE A 1 335 ? 9.83630   4.99910   -5.58270  1.000 29.48278  ? 327 ILE A HB   1 
ATOM   4876 H  HG12 . ILE A 1 335 ? 11.08065  2.52614   -5.07669  1.000 24.83926  ? 327 ILE A HG12 1 
ATOM   4877 H  HG13 . ILE A 1 335 ? 9.69314   2.87688   -4.38588  1.000 24.83926  ? 327 ILE A HG13 1 
ATOM   4878 H  HG21 . ILE A 1 335 ? 11.56009  4.45674   -7.04844  1.000 32.01077  ? 327 ILE A HG21 1 
ATOM   4879 H  HG22 . ILE A 1 335 ? 12.04222  5.66887   -6.14191  1.000 32.01077  ? 327 ILE A HG22 1 
ATOM   4880 H  HG23 . ILE A 1 335 ? 12.54323  4.19432   -5.82857  1.000 32.01077  ? 327 ILE A HG23 1 
ATOM   4881 H  HD11 . ILE A 1 335 ? 9.29429   1.59915   -6.22978  1.000 27.70732  ? 327 ILE A HD11 1 
ATOM   4882 H  HD12 . ILE A 1 335 ? 8.72565   3.05870   -6.49411  1.000 27.70732  ? 327 ILE A HD12 1 
ATOM   4883 H  HD13 . ILE A 1 335 ? 10.10644  2.61481   -7.14211  1.000 27.70732  ? 327 ILE A HD13 1 
ATOM   4884 N  N    . LEU A 1 336 ? 11.84107  3.48356   -2.25795  1.000 18.06771  ? 328 LEU A N    1 
ATOM   4885 C  CA   . LEU A 1 336 ? 12.87360  2.70592   -1.58999  1.000 19.22733  ? 328 LEU A CA   1 
ATOM   4886 C  C    . LEU A 1 336 ? 12.96289  1.33562   -2.24896  1.000 22.65867  ? 328 LEU A C    1 
ATOM   4887 O  O    . LEU A 1 336 ? 12.01504  0.54145   -2.16868  1.000 15.02873  ? 328 LEU A O    1 
ATOM   4888 C  CB   . LEU A 1 336 ? 12.55603  2.55780   -0.10398  1.000 19.36452  ? 328 LEU A CB   1 
ATOM   4889 C  CG   . LEU A 1 336 ? 12.27687  3.83367   0.69315   1.000 21.46882  ? 328 LEU A CG   1 
ATOM   4890 C  CD1  . LEU A 1 336 ? 12.01258  3.45914   2.16936   1.000 21.81455  ? 328 LEU A CD1  1 
ATOM   4891 C  CD2  . LEU A 1 336 ? 13.42795  4.79498   0.59336   1.000 19.78481  ? 328 LEU A CD2  1 
ATOM   4892 H  H    . LEU A 1 336 ? 11.04886  3.30784   -1.97313  1.000 21.65807  ? 328 LEU A H    1 
ATOM   4893 H  HA   . LEU A 1 336 ? 13.72962  3.15257   -1.68302  1.000 23.04961  ? 328 LEU A HA   1 
ATOM   4894 H  HB2  . LEU A 1 336 ? 11.76682  1.99950   -0.02430  1.000 23.21424  ? 328 LEU A HB2  1 
ATOM   4895 H  HB3  . LEU A 1 336 ? 13.31356  2.12367   0.31863   1.000 23.21424  ? 328 LEU A HB3  1 
ATOM   4896 H  HG   . LEU A 1 336 ? 11.49587  4.27977   0.32994   1.000 25.73940  ? 328 LEU A HG   1 
ATOM   4897 H  HD11 . LEU A 1 336 ? 11.85250  4.26999   2.67709   1.000 26.15427  ? 328 LEU A HD11 1 
ATOM   4898 H  HD12 . LEU A 1 336 ? 11.23445  2.88172   2.21422   1.000 26.15427  ? 328 LEU A HD12 1 
ATOM   4899 H  HD13 . LEU A 1 336 ? 12.78879  2.99615   2.52154   1.000 26.15427  ? 328 LEU A HD13 1 
ATOM   4900 H  HD21 . LEU A 1 336 ? 13.24162  5.56933   1.14704   1.000 23.71858  ? 328 LEU A HD21 1 
ATOM   4901 H  HD22 . LEU A 1 336 ? 14.23511  4.35427   0.90185   1.000 23.71858  ? 328 LEU A HD22 1 
ATOM   4902 H  HD23 . LEU A 1 336 ? 13.53269  5.06729   -0.33173  1.000 23.71858  ? 328 LEU A HD23 1 
ATOM   4903 N  N    . VAL A 1 337 ? 14.09815  1.06395   -2.88702  1.000 16.23964  ? 329 VAL A N    1 
ATOM   4904 C  CA   . VAL A 1 337 ? 14.35606  -0.20454  -3.55532  1.000 20.74238  ? 329 VAL A CA   1 
ATOM   4905 C  C    . VAL A 1 337 ? 15.16577  -1.10066  -2.62339  1.000 21.76217  ? 329 VAL A C    1 
ATOM   4906 O  O    . VAL A 1 337 ? 16.30517  -0.77921  -2.26260  1.000 17.33910  ? 329 VAL A O    1 
ATOM   4907 C  CB   . VAL A 1 337 ? 15.08474  0.01649   -4.88735  1.000 18.69800  ? 329 VAL A CB   1 
ATOM   4908 C  CG1  . VAL A 1 337 ? 15.29477  -1.29945  -5.56913  1.000 23.13623  ? 329 VAL A CG1  1 
ATOM   4909 C  CG2  . VAL A 1 337 ? 14.28380  0.98820   -5.77160  1.000 15.90546  ? 329 VAL A CG2  1 
ATOM   4910 H  H    . VAL A 1 337 ? 14.75358  1.61745   -2.94733  1.000 19.46438  ? 329 VAL A H    1 
ATOM   4911 H  HA   . VAL A 1 337 ? 13.51226  -0.65026  -3.72921  1.000 24.86767  ? 329 VAL A HA   1 
ATOM   4912 H  HB   . VAL A 1 337 ? 15.95502  0.41458   -4.72913  1.000 22.41441  ? 329 VAL A HB   1 
ATOM   4913 H  HG11 . VAL A 1 337 ? 15.68186  -1.14325  -6.44472  1.000 27.74029  ? 329 VAL A HG11 1 
ATOM   4914 H  HG12 . VAL A 1 337 ? 15.89593  -1.84028  -5.03340  1.000 27.74029  ? 329 VAL A HG12 1 
ATOM   4915 H  HG13 . VAL A 1 337 ? 14.43945  -1.74770  -5.66078  1.000 27.74029  ? 329 VAL A HG13 1 
ATOM   4916 H  HG21 . VAL A 1 337 ? 14.74351  1.09616   -6.61889  1.000 19.06336  ? 329 VAL A HG21 1 
ATOM   4917 H  HG22 . VAL A 1 337 ? 13.39771  0.62263   -5.92026  1.000 19.06336  ? 329 VAL A HG22 1 
ATOM   4918 H  HG23 . VAL A 1 337 ? 14.21703  1.84411   -5.32009  1.000 19.06336  ? 329 VAL A HG23 1 
ATOM   4919 N  N    . ILE A 1 338 ? 14.58721  -2.23947  -2.25296  1.000 18.45495  ? 330 ILE A N    1 
ATOM   4920 C  CA   . ILE A 1 338 ? 15.18127  -3.15650  -1.28669  1.000 20.10358  ? 330 ILE A CA   1 
ATOM   4921 C  C    . ILE A 1 338 ? 15.65340  -4.39377  -2.03609  1.000 24.66084  ? 330 ILE A C    1 
ATOM   4922 O  O    . ILE A 1 338 ? 14.88805  -4.98659  -2.80701  1.000 24.21080  ? 330 ILE A O    1 
ATOM   4923 C  CB   . ILE A 1 338 ? 14.18402  -3.55190  -0.18076  1.000 20.40861  ? 330 ILE A CB   1 
ATOM   4924 C  CG1  . ILE A 1 338 ? 13.53286  -2.32248  0.44048   1.000 21.76707  ? 330 ILE A CG1  1 
ATOM   4925 C  CG2  . ILE A 1 338 ? 14.86804  -4.43114  0.88236   1.000 23.06478  ? 330 ILE A CG2  1 
ATOM   4926 C  CD1  . ILE A 1 338 ? 14.35629  -1.65477  1.45092   1.000 27.56745  ? 330 ILE A CD1  1 
ATOM   4927 H  H    . ILE A 1 338 ? 13.82914  -2.50898  -2.55675  1.000 22.12275  ? 330 ILE A H    1 
ATOM   4928 H  HA   . ILE A 1 338 ? 15.94424  -2.72406  -0.87223  1.000 24.10111  ? 330 ILE A HA   1 
ATOM   4929 H  HB   . ILE A 1 338 ? 13.47703  -4.07568  -0.58906  1.000 24.46714  ? 330 ILE A HB   1 
ATOM   4930 H  HG12 . ILE A 1 338 ? 13.35018  -1.67939  -0.26235  1.000 26.09729  ? 330 ILE A HG12 1 
ATOM   4931 H  HG13 . ILE A 1 338 ? 12.70443  -2.59208  0.86700   1.000 26.09729  ? 330 ILE A HG13 1 
ATOM   4932 H  HG21 . ILE A 1 338 ? 14.24393  -4.59369  1.60690   1.000 27.65455  ? 330 ILE A HG21 1 
ATOM   4933 H  HG22 . ILE A 1 338 ? 15.12943  -5.27223  0.47598   1.000 27.65455  ? 330 ILE A HG22 1 
ATOM   4934 H  HG23 . ILE A 1 338 ? 15.65161  -3.96846  1.21828   1.000 27.65455  ? 330 ILE A HG23 1 
ATOM   4935 H  HD11 . ILE A 1 338 ? 13.90357  -0.84890  1.74505   1.000 33.05775  ? 330 ILE A HD11 1 
ATOM   4936 H  HD12 . ILE A 1 338 ? 14.48361  -2.25546  2.20182   1.000 33.05775  ? 330 ILE A HD12 1 
ATOM   4937 H  HD13 . ILE A 1 338 ? 15.21437  -1.42802  1.05953   1.000 33.05775  ? 330 ILE A HD13 1 
ATOM   4938 N  N    . ASP A 1 339 ? 16.90268  -4.79200  -1.80430  1.000 23.34495  ? 331 ASP A N    1 
ATOM   4939 C  CA   . ASP A 1 339 ? 17.40737  -6.07310  -2.28482  1.000 20.68972  ? 331 ASP A CA   1 
ATOM   4940 C  C    . ASP A 1 339 ? 18.28990  -6.67851  -1.20443  1.000 18.16439  ? 331 ASP A C    1 
ATOM   4941 O  O    . ASP A 1 339 ? 18.64510  -6.02044  -0.23278  1.000 17.95235  ? 331 ASP A O    1 
ATOM   4942 C  CB   . ASP A 1 339 ? 18.19204  -5.93257  -3.59232  1.000 18.48771  ? 331 ASP A CB   1 
ATOM   4943 C  CG   . ASP A 1 339 ? 18.06962  -7.15721  -4.48797  1.000 23.84175  ? 331 ASP A CG   1 
ATOM   4944 O  OD1  . ASP A 1 339 ? 17.25392  -8.05653  -4.20850  1.000 26.94706  ? 331 ASP A OD1  1 
ATOM   4945 O  OD2  . ASP A 1 339 ? 18.78950  -7.21671  -5.49827  1.000 22.03923  ? 331 ASP A OD2  1 
ATOM   4946 H  H    . ASP A 1 339 ? 17.48214  -4.33169  -1.36619  1.000 27.99076  ? 331 ASP A H    1 
ATOM   4947 H  HA   . ASP A 1 339 ? 16.65737  -6.66524  -2.45149  1.000 24.80448  ? 331 ASP A HA   1 
ATOM   4948 H  HB2  . ASP A 1 339 ? 17.85390  -5.16724  -4.08306  1.000 22.16206  ? 331 ASP A HB2  1 
ATOM   4949 H  HB3  . ASP A 1 339 ? 19.13108  -5.80533  -3.38516  1.000 22.16206  ? 331 ASP A HB3  1 
ATOM   4950 N  N    . ASP A 1 340 ? 18.65767  -7.94545  -1.37287  1.000 24.32525  ? 332 ASP A N    1 
ATOM   4951 C  CA   . ASP A 1 340 ? 19.39726  -8.63597  -0.32004  1.000 27.15360  ? 332 ASP A CA   1 
ATOM   4952 C  C    . ASP A 1 340 ? 20.90052  -8.37363  -0.39796  1.000 24.10438  ? 332 ASP A C    1 
ATOM   4953 O  O    . ASP A 1 340 ? 21.49951  -7.87729  0.56082   1.000 29.36052  ? 332 ASP A O    1 
ATOM   4954 C  CB   . ASP A 1 340 ? 19.10188  -10.13797 -0.37695  1.000 25.26095  ? 332 ASP A CB   1 
ATOM   4955 C  CG   . ASP A 1 340 ? 19.24029  -10.72949 -1.77114  1.000 23.88252  ? 332 ASP A CG   1 
ATOM   4956 O  OD1  . ASP A 1 340 ? 19.67708  -10.04471 -2.71266  1.000 20.10054  ? 332 ASP A OD1  1 
ATOM   4957 O  OD2  . ASP A 1 340 ? 18.91197  -11.91741 -1.92555  1.000 38.62557  ? 332 ASP A OD2  1 
ATOM   4958 H  H    . ASP A 1 340 ? 18.49441  -8.41737  -2.07304  1.000 29.16711  ? 332 ASP A H    1 
ATOM   4959 H  HA   . ASP A 1 340 ? 19.09231  -8.29772  0.53641   1.000 32.56114  ? 332 ASP A HA   1 
ATOM   4960 H  HB2  . ASP A 1 340 ? 19.72341  -10.60194 0.20558   1.000 30.28995  ? 332 ASP A HB2  1 
ATOM   4961 H  HB3  . ASP A 1 340 ? 18.19139  -10.28988 -0.07891  1.000 30.28995  ? 332 ASP A HB3  1 
ATOM   4962 N  N    . PHE A 1 341 ? 21.51674  -8.69334  -1.53189  1.000 21.70871  ? 333 PHE A N    1 
ATOM   4963 C  CA   . PHE A 1 341 ? 22.95511  -8.55265  -1.70716  1.000 33.73859  ? 333 PHE A CA   1 
ATOM   4964 C  C    . PHE A 1 341 ? 23.25742  -7.39560  -2.64676  1.000 24.25788  ? 333 PHE A C    1 
ATOM   4965 O  O    . PHE A 1 341 ? 22.58997  -7.22375  -3.66994  1.000 32.04539  ? 333 PHE A O    1 
ATOM   4966 C  CB   . PHE A 1 341 ? 23.57847  -9.83547  -2.27434  1.000 31.85427  ? 333 PHE A CB   1 
ATOM   4967 C  CG   . PHE A 1 341 ? 23.57616  -10.98436 -1.31839  1.000 38.34137  ? 333 PHE A CG   1 
ATOM   4968 C  CD1  . PHE A 1 341 ? 24.56183  -11.09779 -0.35632  1.000 37.81806  ? 333 PHE A CD1  1 
ATOM   4969 C  CD2  . PHE A 1 341 ? 22.58708  -11.95379 -1.37803  1.000 33.31114  ? 333 PHE A CD2  1 
ATOM   4970 C  CE1  . PHE A 1 341 ? 24.56002  -12.15679 0.53752   1.000 37.30181  ? 333 PHE A CE1  1 
ATOM   4971 C  CE2  . PHE A 1 341 ? 22.57945  -13.01296 -0.48450  1.000 40.20218  ? 333 PHE A CE2  1 
ATOM   4972 C  CZ   . PHE A 1 341 ? 23.57482  -13.11669 0.47032   1.000 45.47679  ? 333 PHE A CZ   1 
ATOM   4973 H  H    . PHE A 1 341 ? 21.11298  -8.99981  -2.22662  1.000 26.02726  ? 333 PHE A H    1 
ATOM   4974 H  HA   . PHE A 1 341 ? 23.35789  -8.36790  -0.84429  1.000 40.46311  ? 333 PHE A HA   1 
ATOM   4975 H  HB2  . PHE A 1 341 ? 23.07716  -10.10406 -3.06012  1.000 38.20194  ? 333 PHE A HB2  1 
ATOM   4976 H  HB3  . PHE A 1 341 ? 24.50031  -9.65346  -2.51513  1.000 38.20194  ? 333 PHE A HB3  1 
ATOM   4977 H  HD1  . PHE A 1 341 ? 25.23362  -10.45647 -0.30824  1.000 45.35848  ? 333 PHE A HD1  1 
ATOM   4978 H  HD2  . PHE A 1 341 ? 21.92148  -11.89268 -2.02466  1.000 39.95017  ? 333 PHE A HD2  1 
ATOM   4979 H  HE1  . PHE A 1 341 ? 25.22552  -12.21939 1.18411   1.000 44.73898  ? 333 PHE A HE1  1 
ATOM   4980 H  HE2  . PHE A 1 341 ? 21.90612  -13.65307 -0.52676  1.000 48.21943  ? 333 PHE A HE2  1 
ATOM   4981 H  HZ   . PHE A 1 341 ? 23.57874  -13.83196 1.06469   1.000 54.54895  ? 333 PHE A HZ   1 
ATOM   4982 N  N    . CYS A 1 342 ? 24.28219  -6.62188  -2.30588  1.000 24.74620  ? 334 CYS A N    1 
ATOM   4983 C  CA   . CYS A 1 342 ? 24.86392  -5.62907  -3.20223  1.000 27.15668  ? 334 CYS A CA   1 
ATOM   4984 C  C    . CYS A 1 342 ? 26.35138  -5.94134  -3.31406  1.000 33.37210  ? 334 CYS A C    1 
ATOM   4985 O  O    . CYS A 1 342 ? 27.08312  -5.83319  -2.32412  1.000 32.87864  ? 334 CYS A O    1 
ATOM   4986 C  CB   . CYS A 1 342 ? 24.64142  -4.20605  -2.69115  1.000 25.42968  ? 334 CYS A CB   1 
ATOM   4987 S  SG   . CYS A 1 342 ? 25.29085  -2.93875  -3.85638  1.000 33.58270  ? 334 CYS A SG   1 
ATOM   4988 H  H    . CYS A 1 342 ? 24.66859  -6.65474  -1.53828  1.000 29.67225  ? 334 CYS A H    1 
ATOM   4989 H  HA   . CYS A 1 342 ? 24.45025  -5.69567  -4.07707  1.000 32.56483  ? 334 CYS A HA   1 
ATOM   4990 H  HB2  . CYS A 1 342 ? 23.69005  -4.05424  -2.57820  1.000 30.49242  ? 334 CYS A HB2  1 
ATOM   4991 H  HB3  . CYS A 1 342 ? 25.09765  -4.09858  -1.84191  1.000 30.49242  ? 334 CYS A HB3  1 
ATOM   4992 H  HG   . CYS A 1 342 ? 25.09839  -1.84810  -3.39437  1.000 40.27605  ? 334 CYS A HG   1 
ATOM   4993 N  N    . THR A 1 343 ? 26.79662  -6.34812  -4.50638  1.000 30.40662  ? 335 THR A N    1 
ATOM   4994 C  CA   . THR A 1 343 ? 28.21043  -6.62747  -4.73343  1.000 30.49123  ? 335 THR A CA   1 
ATOM   4995 C  C    . THR A 1 343 ? 28.82118  -5.50248  -5.55480  1.000 27.26056  ? 335 THR A C    1 
ATOM   4996 O  O    . THR A 1 343 ? 29.48265  -4.62422  -4.99477  1.000 29.40785  ? 335 THR A O    1 
ATOM   4997 C  CB   . THR A 1 343 ? 28.39547  -7.97920  -5.41621  1.000 28.55821  ? 335 THR A CB   1 
ATOM   4998 O  OG1  . THR A 1 343 ? 27.80179  -8.99095  -4.59414  1.000 38.87017  ? 335 THR A OG1  1 
ATOM   4999 C  CG2  . THR A 1 343 ? 29.86664  -8.28781  -5.58552  1.000 33.75656  ? 335 THR A CG2  1 
ATOM   5000 H  H    . THR A 1 343 ? 26.29812  -6.46875  -5.19670  1.000 36.46476  ? 335 THR A H    1 
ATOM   5001 H  HA   . THR A 1 343 ? 28.67916  -6.67940  -3.88579  1.000 36.56629  ? 335 THR A HA   1 
ATOM   5002 H  HB   . THR A 1 343 ? 27.98047  -7.96867  -6.29289  1.000 34.24667  ? 335 THR A HB   1 
ATOM   5003 H  HG1  . THR A 1 343 ? 28.02556  -9.75246  -4.86915  1.000 46.62101  ? 335 THR A HG1  1 
ATOM   5004 H  HG21 . THR A 1 343 ? 29.97828  -9.17304  -5.96604  1.000 40.48469  ? 335 THR A HG21 1 
ATOM   5005 H  HG22 . THR A 1 343 ? 30.27623  -7.63704  -6.17683  1.000 40.48469  ? 335 THR A HG22 1 
ATOM   5006 H  HG23 . THR A 1 343 ? 30.31338  -8.25639  -4.72509  1.000 40.48469  ? 335 THR A HG23 1 
ATOM   5007 N  N    . GLU A 1 344 ? 28.58825  -5.50230  -6.86833  1.000 24.19691  ? 336 GLU A N    1 
ATOM   5008 C  CA   . GLU A 1 344 ? 29.07410  -4.44765  -7.74666  1.000 26.38506  ? 336 GLU A CA   1 
ATOM   5009 C  C    . GLU A 1 344 ? 27.96437  -3.53423  -8.24279  1.000 32.82975  ? 336 GLU A C    1 
ATOM   5010 O  O    . GLU A 1 344 ? 28.24792  -2.59897  -9.00148  1.000 28.88779  ? 336 GLU A O    1 
ATOM   5011 C  CB   . GLU A 1 344 ? 29.81709  -5.05311  -8.94083  1.000 37.30086  ? 336 GLU A CB   1 
ATOM   5012 C  CG   . GLU A 1 344 ? 31.06722  -5.82932  -8.53815  1.000 37.85016  ? 336 GLU A CG   1 
ATOM   5013 C  CD   . GLU A 1 344 ? 31.79752  -6.42035  -9.71695  1.000 45.20848  ? 336 GLU A CD   1 
ATOM   5014 O  OE1  . GLU A 1 344 ? 31.26374  -6.35611  -10.84663 1.000 43.12345  ? 336 GLU A OE1  1 
ATOM   5015 O  OE2  . GLU A 1 344 ? 32.90725  -6.95056  -9.50243  1.000 51.19479  ? 336 GLU A OE2  1 
ATOM   5016 H  H    . GLU A 1 344 ? 28.14337  -6.11429  -7.27717  1.000 29.01311  ? 336 GLU A H    1 
ATOM   5017 H  HA   . GLU A 1 344 ? 29.70618  -3.90260  -7.25240  1.000 31.63888  ? 336 GLU A HA   1 
ATOM   5018 H  HB2  . GLU A 1 344 ? 29.22253  -5.66373  -9.40402  1.000 44.73784  ? 336 GLU A HB2  1 
ATOM   5019 H  HB3  . GLU A 1 344 ? 30.08862  -4.33800  -9.53732  1.000 44.73784  ? 336 GLU A HB3  1 
ATOM   5020 H  HG2  . GLU A 1 344 ? 31.67619  -5.23004  -8.07890  1.000 45.39701  ? 336 GLU A HG2  1 
ATOM   5021 H  HG3  . GLU A 1 344 ? 30.81089  -6.55669  -7.94982  1.000 45.39701  ? 336 GLU A HG3  1 
ATOM   5022 N  N    . GLY A 1 345 ? 26.71842  -3.77258  -7.82915  1.000 22.30497  ? 337 GLY A N    1 
ATOM   5023 C  CA   . GLY A 1 345 ? 25.62784  -2.85370  -8.07152  1.000 21.26766  ? 337 GLY A CA   1 
ATOM   5024 C  C    . GLY A 1 345 ? 24.86538  -3.07086  -9.35225  1.000 19.24225  ? 337 GLY A C    1 
ATOM   5025 O  O    . GLY A 1 345 ? 24.01108  -2.24511  -9.68951  1.000 23.42497  ? 337 GLY A O    1 
ATOM   5026 H  H    . GLY A 1 345 ? 26.48266  -4.47776  -7.39703  1.000 26.74277  ? 337 GLY A H    1 
ATOM   5027 H  HA2  . GLY A 1 345 ? 24.99610  -2.92628  -7.33904  1.000 25.49801  ? 337 GLY A HA2  1 
ATOM   5028 H  HA3  . GLY A 1 345 ? 25.98455  -1.95192  -8.09271  1.000 25.49801  ? 337 GLY A HA3  1 
ATOM   5029 N  N    . ASN A 1 346 ? 25.15540  -4.14409  -10.08454 1.000 26.45737  ? 338 ASN A N    1 
ATOM   5030 C  CA   . ASN A 1 346 ? 24.48584  -4.37096  -11.36372 1.000 33.06684  ? 338 ASN A CA   1 
ATOM   5031 C  C    . ASN A 1 346 ? 22.96965  -4.36631  -11.20698 1.000 25.50564  ? 338 ASN A C    1 
ATOM   5032 O  O    . ASN A 1 346 ? 22.25285  -3.77411  -12.02375 1.000 22.86686  ? 338 ASN A O    1 
ATOM   5033 C  CB   . ASN A 1 346 ? 24.92733  -5.69979  -11.96592 1.000 36.52501  ? 338 ASN A CB   1 
ATOM   5034 C  CG   . ASN A 1 346 ? 26.31093  -5.65253  -12.56854 1.000 39.02221  ? 338 ASN A CG   1 
ATOM   5035 O  OD1  . ASN A 1 346 ? 26.50455  -5.98164  -13.73680 1.000 41.64607  ? 338 ASN A OD1  1 
ATOM   5036 N  ND2  . ASN A 1 346 ? 27.28519  -5.24708  -11.77154 1.000 50.97881  ? 338 ASN A ND2  1 
ATOM   5037 H  H    . ASN A 1 346 ? 25.72763  -4.74837  -9.86775  1.000 31.72565  ? 338 ASN A H    1 
ATOM   5038 H  HA   . ASN A 1 346 ? 24.74082  -3.65542  -11.96695 1.000 39.65702  ? 338 ASN A HA   1 
ATOM   5039 H  HB2  . ASN A 1 346 ? 24.92901  -6.37496  -11.26947 1.000 43.80682  ? 338 ASN A HB2  1 
ATOM   5040 H  HB3  . ASN A 1 346 ? 24.30549  -5.94851  -12.66760 1.000 43.80682  ? 338 ASN A HB3  1 
ATOM   5041 H  HD21 . ASN A 1 346 ? 28.09172  -5.20242  -12.06668 1.000 61.15139  ? 338 ASN A HD21 1 
ATOM   5042 H  HD22 . ASN A 1 346 ? 27.11224  -5.02806  -10.95808 1.000 61.15139  ? 338 ASN A HD22 1 
ATOM   5043 N  N    . ALA A 1 347 ? 22.46032  -4.98262  -10.14374 1.000 17.58008  ? 339 ALA A N    1 
ATOM   5044 C  CA   . ALA A 1 347 ? 21.01654  -5.06853  -9.96000  1.000 27.21247  ? 339 ALA A CA   1 
ATOM   5045 C  C    . ALA A 1 347 ? 20.42752  -3.72269  -9.57263  1.000 25.14831  ? 339 ALA A C    1 
ATOM   5046 O  O    . ALA A 1 347 ? 19.45293  -3.26216  -10.17768 1.000 19.91424  ? 339 ALA A O    1 
ATOM   5047 C  CB   . ALA A 1 347 ? 20.68589  -6.10925  -8.89594  1.000 21.35511  ? 339 ALA A CB   1 
ATOM   5048 H  H    . ALA A 1 347 ? 22.92326  -5.35471  -9.52177  1.000 21.07291  ? 339 ALA A H    1 
ATOM   5049 H  HA   . ALA A 1 347 ? 20.61707  -5.34661  -10.79904 1.000 32.63177  ? 339 ALA A HA   1 
ATOM   5050 H  HB1  . ALA A 1 347 ? 19.72418  -6.14120  -8.77352  1.000 25.60295  ? 339 ALA A HB1  1 
ATOM   5051 H  HB2  . ALA A 1 347 ? 21.01096  -6.97488  -9.18906  1.000 25.60295  ? 339 ALA A HB2  1 
ATOM   5052 H  HB3  . ALA A 1 347 ? 21.11708  -5.85836  -8.06405  1.000 25.60295  ? 339 ALA A HB3  1 
ATOM   5053 N  N    . HIS A 1 348 ? 21.01237  -3.07436  -8.55961  1.000 23.90822  ? 340 HIS A N    1 
ATOM   5054 C  CA   . HIS A 1 348 ? 20.48302  -1.79622  -8.09418  1.000 24.17609  ? 340 HIS A CA   1 
ATOM   5055 C  C    . HIS A 1 348 ? 20.56389  -0.73685  -9.18616  1.000 19.33305  ? 340 HIS A C    1 
ATOM   5056 O  O    . HIS A 1 348 ? 19.64979  0.08693   -9.33554  1.000 14.36242  ? 340 HIS A O    1 
ATOM   5057 C  CB   . HIS A 1 348 ? 21.23916  -1.33877  -6.84494  1.000 26.06596  ? 340 HIS A CB   1 
ATOM   5058 C  CG   . HIS A 1 348 ? 20.68117  -1.87839  -5.56015  1.000 25.30208  ? 340 HIS A CG   1 
ATOM   5059 N  ND1  . HIS A 1 348 ? 19.36852  -1.69319  -5.18082  1.000 18.83823  ? 340 HIS A ND1  1 
ATOM   5060 C  CD2  . HIS A 1 348 ? 21.26290  -2.58272  -4.55937  1.000 21.36156  ? 340 HIS A CD2  1 
ATOM   5061 C  CE1  . HIS A 1 348 ? 19.16905  -2.24647  -3.99877  1.000 24.51514  ? 340 HIS A CE1  1 
ATOM   5062 N  NE2  . HIS A 1 348 ? 20.29875  -2.80666  -3.60625  1.000 20.63463  ? 340 HIS A NE2  1 
ATOM   5063 H  H    . HIS A 1 348 ? 21.70604  -3.35094  -8.13307  1.000 28.66668  ? 340 HIS A H    1 
ATOM   5064 H  HA   . HIS A 1 348 ? 19.55006  -1.91187  -7.85521  1.000 28.98812  ? 340 HIS A HA   1 
ATOM   5065 H  HB2  . HIS A 1 348 ? 22.16037  -1.63469  -6.91355  1.000 31.25596  ? 340 HIS A HB2  1 
ATOM   5066 H  HB3  . HIS A 1 348 ? 21.20437  -0.37055  -6.79781  1.000 31.25596  ? 340 HIS A HB3  1 
ATOM   5067 H  HD2  . HIS A 1 348 ? 22.14916  -2.86234  -4.52415  1.000 25.61069  ? 340 HIS A HD2  1 
ATOM   5068 H  HE1  . HIS A 1 348 ? 18.36956  -2.24241  -3.52369  1.000 29.39497  ? 340 HIS A HE1  1 
ATOM   5069 N  N    . GLU A 1 349 ? 21.65424  -0.73574  -9.95405  1.000 17.52914  ? 341 GLU A N    1 
ATOM   5070 C  CA   . GLU A 1 349 ? 21.81648  0.27873   -10.98757 1.000 21.68449  ? 341 GLU A CA   1 
ATOM   5071 C  C    . GLU A 1 349 ? 20.78262  0.10465   -12.09223 1.000 21.52754  ? 341 GLU A C    1 
ATOM   5072 O  O    . GLU A 1 349 ? 20.28734  1.09655   -12.64305 1.000 17.85884  ? 341 GLU A O    1 
ATOM   5073 C  CB   . GLU A 1 349 ? 23.22857  0.22798   -11.56978 1.000 17.52921  ? 341 GLU A CB   1 
ATOM   5074 C  CG   . GLU A 1 349 ? 24.28629  0.93347   -10.73231 1.000 22.71238  ? 341 GLU A CG   1 
ATOM   5075 C  CD   . GLU A 1 349 ? 23.98872  2.40875   -10.54860 1.000 26.28766  ? 341 GLU A CD   1 
ATOM   5076 O  OE1  . GLU A 1 349 ? 24.24201  3.19145   -11.49619 1.000 28.80240  ? 341 GLU A OE1  1 
ATOM   5077 O  OE2  . GLU A 1 349 ? 23.48181  2.78299   -9.46205  1.000 21.89646  ? 341 GLU A OE2  1 
ATOM   5078 H  H    . GLU A 1 349 ? 22.30034  -1.30042  -9.89671  1.000 21.01178  ? 341 GLU A H    1 
ATOM   5079 H  HA   . GLU A 1 349 ? 21.69223  1.15222   -10.58448 1.000 25.99820  ? 341 GLU A HA   1 
ATOM   5080 H  HB2  . GLU A 1 349 ? 23.49417  -0.70114  -11.65399 1.000 21.01186  ? 341 GLU A HB2  1 
ATOM   5081 H  HB3  . GLU A 1 349 ? 23.21745  0.65030   -12.44295 1.000 21.01186  ? 341 GLU A HB3  1 
ATOM   5082 H  HG2  . GLU A 1 349 ? 24.32295  0.52182   -9.85475  1.000 27.23166  ? 341 GLU A HG2  1 
ATOM   5083 H  HG3  . GLU A 1 349 ? 25.14650  0.85210   -11.17312 1.000 27.23166  ? 341 GLU A HG3  1 
ATOM   5084 N  N    . THR A 1 350 ? 20.43956  -1.14886  -12.42875 1.000 25.05144  ? 342 THR A N    1 
ATOM   5085 C  CA   . THR A 1 350 ? 19.35975  -1.38650  -13.38558 1.000 19.71380  ? 342 THR A CA   1 
ATOM   5086 C  C    . THR A 1 350 ? 18.01926  -0.92907  -12.82094 1.000 23.11636  ? 342 THR A C    1 
ATOM   5087 O  O    . THR A 1 350 ? 17.24668  -0.24387  -13.50826 1.000 13.40731  ? 342 THR A O    1 
ATOM   5088 C  CB   . THR A 1 350 ? 19.31091  -2.86316  -13.77716 1.000 23.74280  ? 342 THR A CB   1 
ATOM   5089 O  OG1  . THR A 1 350 ? 20.57637  -3.23677  -14.33762 1.000 21.98076  ? 342 THR A OG1  1 
ATOM   5090 C  CG2  . THR A 1 350 ? 18.20587  -3.09739  -14.80307 1.000 16.82145  ? 342 THR A CG2  1 
ATOM   5091 H  H    . THR A 1 350 ? 20.81085  -1.86122  -12.12167 1.000 30.03854  ? 342 THR A H    1 
ATOM   5092 H  HA   . THR A 1 350 ? 19.53723  -0.87689  -14.19162 1.000 23.63337  ? 342 THR A HA   1 
ATOM   5093 H  HB   . THR A 1 350 ? 19.12485  -3.41216  -12.99942 1.000 28.46817  ? 342 THR A HB   1 
ATOM   5094 H  HG1  . THR A 1 350 ? 21.16699  -3.23464  -13.74033 1.000 26.35372  ? 342 THR A HG1  1 
ATOM   5095 H  HG21 . THR A 1 350 ? 18.23885  -4.01247  -15.12312 1.000 20.16255  ? 342 THR A HG21 1 
ATOM   5096 H  HG22 . THR A 1 350 ? 17.33875  -2.93615  -14.39933 1.000 20.16255  ? 342 THR A HG22 1 
ATOM   5097 H  HG23 . THR A 1 350 ? 18.31927  -2.49631  -15.55590 1.000 20.16255  ? 342 THR A HG23 1 
ATOM   5098 N  N    . ALA A 1 351 ? 17.73903  -1.26949  -11.55870 1.000 18.70609  ? 343 ALA A N    1 
ATOM   5099 C  CA   . ALA A 1 351 ? 16.52881  -0.76801  -10.91558 1.000 19.19746  ? 343 ALA A CA   1 
ATOM   5100 C  C    . ALA A 1 351 ? 16.48696  0.75634   -10.95725 1.000 24.27158  ? 343 ALA A C    1 
ATOM   5101 O  O    . ALA A 1 351 ? 15.46411  1.35540   -11.31636 1.000 16.76875  ? 343 ALA A O    1 
ATOM   5102 C  CB   . ALA A 1 351 ? 16.44358  -1.27546  -9.47365  1.000 17.73204  ? 343 ALA A CB   1 
ATOM   5103 H  H    . ALA A 1 351 ? 18.22510  -1.77918  -11.06519 1.000 22.42412  ? 343 ALA A H    1 
ATOM   5104 H  HA   . ALA A 1 351 ? 15.75581  -1.10761  -11.39312 1.000 23.01376  ? 343 ALA A HA   1 
ATOM   5105 H  HB1  . ALA A 1 351 ? 15.63367  -0.93173  -9.06525  1.000 21.25525  ? 343 ALA A HB1  1 
ATOM   5106 H  HB2  . ALA A 1 351 ? 16.42457  -2.24525  -9.48075  1.000 21.25525  ? 343 ALA A HB2  1 
ATOM   5107 H  HB3  . ALA A 1 351 ? 17.21976  -0.96343  -8.98265  1.000 21.25525  ? 343 ALA A HB3  1 
ATOM   5108 N  N    . ARG A 1 352 ? 17.60209  1.40278   -10.60106 1.000 16.87678  ? 344 ARG A N    1 
ATOM   5109 C  CA   . ARG A 1 352 ? 17.64217  2.86097   -10.61243 1.000 19.57818  ? 344 ARG A CA   1 
ATOM   5110 C  C    . ARG A 1 352 ? 17.46193  3.39315   -12.02690 1.000 14.34392  ? 344 ARG A C    1 
ATOM   5111 O  O    . ARG A 1 352 ? 16.74746  4.37634   -12.25145 1.000 15.20421  ? 344 ARG A O    1 
ATOM   5112 C  CB   . ARG A 1 352 ? 18.96119  3.35060   -10.01112 1.000 20.62514  ? 344 ARG A CB   1 
ATOM   5113 C  CG   . ARG A 1 352 ? 19.06499  4.86052   -9.89645  1.000 15.99118  ? 344 ARG A CG   1 
ATOM   5114 C  CD   . ARG A 1 352 ? 20.35997  5.27332   -9.21628  1.000 19.52762  ? 344 ARG A CD   1 
ATOM   5115 N  NE   . ARG A 1 352 ? 21.53451  4.97521   -10.03560 1.000 19.42979  ? 344 ARG A NE   1 
ATOM   5116 C  CZ   . ARG A 1 352 ? 21.90301  5.68043   -11.10276 1.000 29.15249  ? 344 ARG A CZ   1 
ATOM   5117 N  NH1  . ARG A 1 352 ? 21.17929  6.72750   -11.49399 1.000 19.49927  ? 344 ARG A NH1  1 
ATOM   5118 N  NH2  . ARG A 1 352 ? 22.98932  5.33231   -11.78802 1.000 23.53931  ? 344 ARG A NH2  1 
ATOM   5119 H  H    . ARG A 1 352 ? 18.33395  1.02485   -10.35377 1.000 20.22895  ? 344 ARG A H    1 
ATOM   5120 H  HA   . ARG A 1 352 ? 16.92012  3.20670   -10.06469 1.000 23.47063  ? 344 ARG A HA   1 
ATOM   5121 H  HB2  . ARG A 1 352 ? 19.05276  2.98000   -9.11940  1.000 24.72698  ? 344 ARG A HB2  1 
ATOM   5122 H  HB3  . ARG A 1 352 ? 19.69085  3.04655   -10.57329 1.000 24.72698  ? 344 ARG A HB3  1 
ATOM   5123 H  HG2  . ARG A 1 352 ? 19.04654  5.25312   -10.78325 1.000 19.16622  ? 344 ARG A HG2  1 
ATOM   5124 H  HG3  . ARG A 1 352 ? 18.32250  5.19555   -9.36980  1.000 19.16622  ? 344 ARG A HG3  1 
ATOM   5125 H  HD2  . ARG A 1 352 ? 20.34195  6.22889   -9.05055  1.000 23.40995  ? 344 ARG A HD2  1 
ATOM   5126 H  HD3  . ARG A 1 352 ? 20.44654  4.79281   -8.37812  1.000 23.40995  ? 344 ARG A HD3  1 
ATOM   5127 H  HE   . ARG A 1 352 ? 22.01870  4.30012   -9.81329  1.000 23.29256  ? 344 ARG A HE   1 
ATOM   5128 H  HH11 . ARG A 1 352 ? 20.47252  6.94911   -11.05700 1.000 23.37594  ? 344 ARG A HH11 1 
ATOM   5129 H  HH12 . ARG A 1 352 ? 21.41866  7.18212   -12.18364 1.000 23.37594  ? 344 ARG A HH12 1 
ATOM   5130 H  HH21 . ARG A 1 352 ? 23.45346  4.65158   -11.54145 1.000 28.22398  ? 344 ARG A HH21 1 
ATOM   5131 H  HH22 . ARG A 1 352 ? 23.22723  5.78805   -12.47744 1.000 28.22398  ? 344 ARG A HH22 1 
ATOM   5132 N  N    . MET A 1 353 ? 18.09593  2.74857   -12.99833 1.000 16.18067  ? 345 MET A N    1 
ATOM   5133 C  CA   . MET A 1 353 ? 18.00052  3.22652   -14.36986 1.000 16.09216  ? 345 MET A CA   1 
ATOM   5134 C  C    . MET A 1 353 ? 16.54969  3.27515   -14.82431 1.000 18.27292  ? 345 MET A C    1 
ATOM   5135 O  O    . MET A 1 353 ? 16.08269  4.29098   -15.35501 1.000 17.97086  ? 345 MET A O    1 
ATOM   5136 C  CB   . MET A 1 353 ? 18.83464  2.33233   -15.28912 1.000 15.93680  ? 345 MET A CB   1 
ATOM   5137 C  CG   . MET A 1 353 ? 18.83733  2.78372   -16.73730 1.000 19.62691  ? 345 MET A CG   1 
ATOM   5138 S  SD   . MET A 1 353 ? 19.75791  1.71263   -17.83315 1.000 27.16197  ? 345 MET A SD   1 
ATOM   5139 C  CE   . MET A 1 353 ? 21.32015  1.58876   -17.02690 1.000 28.94627  ? 345 MET A CE   1 
ATOM   5140 H  H    . MET A 1 353 ? 18.57901  2.04502   -12.89230 1.000 19.39361  ? 345 MET A H    1 
ATOM   5141 H  HA   . MET A 1 353 ? 18.36985  4.12214   -14.41847 1.000 19.28741  ? 345 MET A HA   1 
ATOM   5142 H  HB2  . MET A 1 353 ? 19.75285  2.33305   -14.97639 1.000 19.10097  ? 345 MET A HB2  1 
ATOM   5143 H  HB3  . MET A 1 353 ? 18.47482  1.43202   -15.25961 1.000 19.10097  ? 345 MET A HB3  1 
ATOM   5144 H  HG2  . MET A 1 353 ? 17.92149  2.81342   -17.05550 1.000 23.52911  ? 345 MET A HG2  1 
ATOM   5145 H  HG3  . MET A 1 353 ? 19.23461  3.66724   -16.78693 1.000 23.52911  ? 345 MET A HG3  1 
ATOM   5146 H  HE1  . MET A 1 353 ? 21.93463  1.10584   -17.60144 1.000 34.71233  ? 345 MET A HE1  1 
ATOM   5147 H  HE2  . MET A 1 353 ? 21.65911  2.48145   -16.85625 1.000 34.71233  ? 345 MET A HE2  1 
ATOM   5148 H  HE3  . MET A 1 353 ? 21.20652  1.11242   -16.18959 1.000 34.71233  ? 345 MET A HE3  1 
ATOM   5149 N  N    . TYR A 1 354 ? 15.81389  2.17674   -14.62081 1.000 19.69747  ? 346 TYR A N    1 
ATOM   5150 C  CA   . TYR A 1 354 ? 14.42717  2.13788   -15.06484 1.000 17.61815  ? 346 TYR A CA   1 
ATOM   5151 C  C    . TYR A 1 354 ? 13.56895  3.11555   -14.27302 1.000 17.72035  ? 346 TYR A C    1 
ATOM   5152 O  O    . TYR A 1 354 ? 12.73660  3.82422   -14.85153 1.000 16.48712  ? 346 TYR A O    1 
ATOM   5153 C  CB   . TYR A 1 354 ? 13.88052  0.70797   -14.96023 1.000 15.56481  ? 346 TYR A CB   1 
ATOM   5154 C  CG   . TYR A 1 354 ? 14.20974  -0.14264  -16.17913 1.000 11.57438  ? 346 TYR A CG   1 
ATOM   5155 C  CD1  . TYR A 1 354 ? 15.41044  -0.82715  -16.27384 1.000 16.55800  ? 346 TYR A CD1  1 
ATOM   5156 C  CD2  . TYR A 1 354 ? 13.31663  -0.25082  -17.23262 1.000 19.20212  ? 346 TYR A CD2  1 
ATOM   5157 C  CE1  . TYR A 1 354 ? 15.72077  -1.57656  -17.39977 1.000 19.93619  ? 346 TYR A CE1  1 
ATOM   5158 C  CE2  . TYR A 1 354 ? 13.60108  -1.01018  -18.34491 1.000 16.14959  ? 346 TYR A CE2  1 
ATOM   5159 C  CZ   . TYR A 1 354 ? 14.80503  -1.66730  -18.43467 1.000 22.42427  ? 346 TYR A CZ   1 
ATOM   5160 O  OH   . TYR A 1 354 ? 15.08197  -2.43081  -19.55124 1.000 19.00113  ? 346 TYR A OH   1 
ATOM   5161 H  H    . TYR A 1 354 ? 16.09142  1.45922   -14.23646 1.000 23.61377  ? 346 TYR A H    1 
ATOM   5162 H  HA   . TYR A 1 354 ? 14.38571  2.39894   -15.99813 1.000 21.11859  ? 346 TYR A HA   1 
ATOM   5163 H  HB2  . TYR A 1 354 ? 14.26804  0.27858   -14.18154 1.000 18.65458  ? 346 TYR A HB2  1 
ATOM   5164 H  HB3  . TYR A 1 354 ? 12.91521  0.74521   -14.87256 1.000 18.65458  ? 346 TYR A HB3  1 
ATOM   5165 H  HD1  . TYR A 1 354 ? 16.01839  -0.78372  -15.57141 1.000 19.84641  ? 346 TYR A HD1  1 
ATOM   5166 H  HD2  . TYR A 1 354 ? 12.50488  0.20073   -17.18722 1.000 23.01935  ? 346 TYR A HD2  1 
ATOM   5167 H  HE1  . TYR A 1 354 ? 16.53870  -2.01518  -17.45901 1.000 23.90024  ? 346 TYR A HE1  1 
ATOM   5168 H  HE2  . TYR A 1 354 ? 12.98023  -1.07845  -19.03395 1.000 19.35632  ? 346 TYR A HE2  1 
ATOM   5169 H  HH   . TYR A 1 354 ? 15.76595  -2.89941  -19.41642 1.000 22.77816  ? 346 TYR A HH   1 
ATOM   5170 N  N    . LEU A 1 355 ? 13.73605  3.15511   -12.94650 1.000 15.72981  ? 347 LEU A N    1 
ATOM   5171 C  CA   . LEU A 1 355 ? 12.91099  4.04770   -12.13956 1.000 18.38252  ? 347 LEU A CA   1 
ATOM   5172 C  C    . LEU A 1 355 ? 13.25380  5.50543   -12.42245 1.000 20.98060  ? 347 LEU A C    1 
ATOM   5173 O  O    . LEU A 1 355 ? 12.36458  6.36594   -12.46794 1.000 19.61384  ? 347 LEU A O    1 
ATOM   5174 C  CB   . LEU A 1 355 ? 13.08552  3.72844   -10.65616 1.000 17.25176  ? 347 LEU A CB   1 
ATOM   5175 C  CG   . LEU A 1 355 ? 12.46347  2.41372   -10.18972 1.000 19.86626  ? 347 LEU A CG   1 
ATOM   5176 C  CD1  . LEU A 1 355 ? 12.92089  2.05422   -8.78206  1.000 19.67264  ? 347 LEU A CD1  1 
ATOM   5177 C  CD2  . LEU A 1 355 ? 10.93752  2.49920   -10.23551 1.000 14.65840  ? 347 LEU A CD2  1 
ATOM   5178 H  H    . LEU A 1 355 ? 14.30566  2.68669   -12.50409 1.000 18.85258  ? 347 LEU A H    1 
ATOM   5179 H  HA   . LEU A 1 355 ? 11.97790  3.90607   -12.36358 1.000 22.03584  ? 347 LEU A HA   1 
ATOM   5180 H  HB2  . LEU A 1 355 ? 14.03524  3.68358   -10.46404 1.000 20.67893  ? 347 LEU A HB2  1 
ATOM   5181 H  HB3  . LEU A 1 355 ? 12.67615  4.44119   -10.14108 1.000 20.67893  ? 347 LEU A HB3  1 
ATOM   5182 H  HG   . LEU A 1 355 ? 12.75613  1.70896   -10.78852 1.000 23.81633  ? 347 LEU A HG   1 
ATOM   5183 H  HD11 . LEU A 1 355 ? 12.51637  1.21114   -8.52421  1.000 23.58398  ? 347 LEU A HD11 1 
ATOM   5184 H  HD12 . LEU A 1 355 ? 13.88747  1.97314   -8.77514  1.000 23.58398  ? 347 LEU A HD12 1 
ATOM   5185 H  HD13 . LEU A 1 355 ? 12.64333  2.75478   -8.17125  1.000 23.58398  ? 347 LEU A HD13 1 
ATOM   5186 H  HD21 . LEU A 1 355 ? 10.56471  1.65914   -9.92533  1.000 17.56689  ? 347 LEU A HD21 1 
ATOM   5187 H  HD22 . LEU A 1 355 ? 10.64441  3.22346   -9.66068  1.000 17.56689  ? 347 LEU A HD22 1 
ATOM   5188 H  HD23 . LEU A 1 355 ? 10.65794  2.66797   -11.14888 1.000 17.56689  ? 347 LEU A HD23 1 
ATOM   5189 N  N    . LYS A 1 356 ? 14.53585  5.79963   -12.64520 1.000 20.20454  ? 348 LYS A N    1 
ATOM   5190 C  CA   . LYS A 1 356 ? 14.91834  7.16580   -12.98571 1.000 20.10030  ? 348 LYS A CA   1 
ATOM   5191 C  C    . LYS A 1 356 ? 14.29651  7.58929   -14.30693 1.000 21.48964  ? 348 LYS A C    1 
ATOM   5192 O  O    . LYS A 1 356 ? 13.73885  8.68650   -14.41589 1.000 22.70846  ? 348 LYS A O    1 
ATOM   5193 C  CB   . LYS A 1 356 ? 16.43571  7.29700   -13.05328 1.000 19.58056  ? 348 LYS A CB   1 
ATOM   5194 C  CG   . LYS A 1 356 ? 16.93009  8.70817   -13.35708 1.000 21.86701  ? 348 LYS A CG   1 
ATOM   5195 C  CD   . LYS A 1 356 ? 18.44933  8.75938   -13.42852 1.000 22.48451  ? 348 LYS A CD   1 
ATOM   5196 C  CE   . LYS A 1 356 ? 18.92997  10.10439  -13.95252 1.000 25.99900  ? 348 LYS A CE   1 
ATOM   5197 N  NZ   . LYS A 1 356 ? 20.40008  10.10369  -14.17592 1.000 32.91817  ? 348 LYS A NZ   1 
ATOM   5198 H  H    . LYS A 1 356 ? 15.18681  5.23899   -12.60608 1.000 24.22225  ? 348 LYS A H    1 
ATOM   5199 H  HA   . LYS A 1 356 ? 14.59768  7.75622   -12.28609 1.000 24.09717  ? 348 LYS A HA   1 
ATOM   5200 H  HB2  . LYS A 1 356 ? 16.80795  7.03299   -12.19734 1.000 23.47348  ? 348 LYS A HB2  1 
ATOM   5201 H  HB3  . LYS A 1 356 ? 16.76636  6.71259   -13.75330 1.000 23.47348  ? 348 LYS A HB3  1 
ATOM   5202 H  HG2  . LYS A 1 356 ? 16.57414  8.99688   -14.21197 1.000 26.21723  ? 348 LYS A HG2  1 
ATOM   5203 H  HG3  . LYS A 1 356 ? 16.63678  9.31007   -12.65524 1.000 26.21723  ? 348 LYS A HG3  1 
ATOM   5204 H  HD2  . LYS A 1 356 ? 18.81857  8.62668   -12.54142 1.000 26.95822  ? 348 LYS A HD2  1 
ATOM   5205 H  HD3  . LYS A 1 356 ? 18.76759  8.06594   -14.02748 1.000 26.95822  ? 348 LYS A HD3  1 
ATOM   5206 H  HE2  . LYS A 1 356 ? 18.49248  10.29578  -14.79684 1.000 31.17561  ? 348 LYS A HE2  1 
ATOM   5207 H  HE3  . LYS A 1 356 ? 18.71934  10.79571  -13.30553 1.000 31.17561  ? 348 LYS A HE3  1 
ATOM   5208 H  HZ1  . LYS A 1 356 ? 20.64538  10.85221  -14.59021 1.000 39.47861  ? 348 LYS A HZ1  1 
ATOM   5209 H  HZ2  . LYS A 1 356 ? 20.82641  10.05200  -13.39639 1.000 39.47861  ? 348 LYS A HZ2  1 
ATOM   5210 H  HZ3  . LYS A 1 356 ? 20.63129  9.40641   -14.67836 1.000 39.47861  ? 348 LYS A HZ3  1 
ATOM   5211 N  N    . ALA A 1 357 ? 14.36266  6.71554   -15.31973 1.000 23.30743  ? 349 ALA A N    1 
ATOM   5212 C  CA   . ALA A 1 357 ? 13.76103  7.02059   -16.61266 1.000 20.43583  ? 349 ALA A CA   1 
ATOM   5213 C  C    . ALA A 1 357 ? 12.27639  7.32867   -16.48127 1.000 19.30955  ? 349 ALA A C    1 
ATOM   5214 O  O    . ALA A 1 357 ? 11.73607  8.10927   -17.26543 1.000 21.98640  ? 349 ALA A O    1 
ATOM   5215 C  CB   . ALA A 1 357 ? 13.98088  5.85481   -17.57615 1.000 22.37257  ? 349 ALA A CB   1 
ATOM   5216 H  H    . ALA A 1 357 ? 14.74747  5.94744   -15.28035 1.000 27.94572  ? 349 ALA A H    1 
ATOM   5217 H  HA   . ALA A 1 357 ? 14.19526  7.80436   -16.98420 1.000 24.49980  ? 349 ALA A HA   1 
ATOM   5218 H  HB1  . ALA A 1 357 ? 13.58558  6.07531   -18.43407 1.000 26.82390  ? 349 ALA A HB1  1 
ATOM   5219 H  HB2  . ALA A 1 357 ? 14.93380  5.70593   -17.67950 1.000 26.82390  ? 349 ALA A HB2  1 
ATOM   5220 H  HB3  . ALA A 1 357 ? 13.55955  5.06052   -17.21217 1.000 26.82390  ? 349 ALA A HB3  1 
ATOM   5221 N  N    . ALA A 1 358 ? 11.60412  6.73931   -15.50288 1.000 22.94750  ? 350 ALA A N    1 
ATOM   5222 C  CA   . ALA A 1 358 ? 10.19640  7.00405   -15.24808 1.000 19.97800  ? 350 ALA A CA   1 
ATOM   5223 C  C    . ALA A 1 358 ? 9.98422   8.19918   -14.33030 1.000 18.42860  ? 350 ALA A C    1 
ATOM   5224 O  O    . ALA A 1 358 ? 8.84366   8.48038   -13.95326 1.000 25.14943  ? 350 ALA A O    1 
ATOM   5225 C  CB   . ALA A 1 358 ? 9.54369   5.75804   -14.64550 1.000 20.77211  ? 350 ALA A CB   1 
ATOM   5226 H  H    . ALA A 1 358 ? 11.94960  6.16864   -14.96013 1.000 27.51381  ? 350 ALA A H    1 
ATOM   5227 H  HA   . ALA A 1 358 ? 9.74904   7.19794   -16.08664 1.000 23.95041  ? 350 ALA A HA   1 
ATOM   5228 H  HB1  . ALA A 1 358 ? 8.60763   5.94430   -14.47231 1.000 24.90334  ? 350 ALA A HB1  1 
ATOM   5229 H  HB2  . ALA A 1 358 ? 9.62403   5.02395   -15.27444 1.000 24.90334  ? 350 ALA A HB2  1 
ATOM   5230 H  HB3  . ALA A 1 358 ? 9.99531   5.53445   -13.81668 1.000 24.90334  ? 350 ALA A HB3  1 
ATOM   5231 N  N    . GLY A 1 359 ? 11.04931  8.90035   -13.95640 1.000 28.62723  ? 351 GLY A N    1 
ATOM   5232 C  CA   . GLY A 1 359 ? 10.93060  10.15278  -13.23476 1.000 26.75496  ? 351 GLY A CA   1 
ATOM   5233 C  C    . GLY A 1 359 ? 10.96883  10.05354  -11.72787 1.000 28.45915  ? 351 GLY A C    1 
ATOM   5234 O  O    . GLY A 1 359 ? 10.69596  11.05224  -11.04710 1.000 26.69672  ? 351 GLY A O    1 
ATOM   5235 H  H    . GLY A 1 359 ? 11.86159  8.66518   -14.11291 1.000 34.32949  ? 351 GLY A H    1 
ATOM   5236 H  HA2  . GLY A 1 359 ? 11.65861  10.73316  -13.50691 1.000 32.08277  ? 351 GLY A HA2  1 
ATOM   5237 H  HA3  . GLY A 1 359 ? 10.08819  10.56763  -13.47796 1.000 32.08277  ? 351 GLY A HA3  1 
ATOM   5238 N  N    . ALA A 1 360 ? 11.31044  8.89948   -11.18254 1.000 26.80866  ? 352 ALA A N    1 
ATOM   5239 C  CA   . ALA A 1 360 ? 11.26773  8.71603   -9.74342  1.000 27.27054  ? 352 ALA A CA   1 
ATOM   5240 C  C    . ALA A 1 360 ? 12.58479  9.14476   -9.10351  1.000 21.43169  ? 352 ALA A C    1 
ATOM   5241 O  O    . ALA A 1 360 ? 13.62364  9.20989   -9.75274  1.000 25.29912  ? 352 ALA A O    1 
ATOM   5242 C  CB   . ALA A 1 360 ? 10.96407  7.25632   -9.41190  1.000 24.40519  ? 352 ALA A CB   1 
ATOM   5243 H  H    . ALA A 1 360 ? 11.57007  8.20844   -11.62373 1.000 32.14720  ? 352 ALA A H    1 
ATOM   5244 H  HA   . ALA A 1 360 ? 10.56518  9.26751   -9.36501  1.000 32.70145  ? 352 ALA A HA   1 
ATOM   5245 H  HB1  . ALA A 1 360 ? 10.93603  7.15061   -8.44809  1.000 29.26304  ? 352 ALA A HB1  1 
ATOM   5246 H  HB2  . ALA A 1 360 ? 10.10607  7.01713   -9.79600  1.000 29.26304  ? 352 ALA A HB2  1 
ATOM   5247 H  HB3  . ALA A 1 360 ? 11.66175  6.69579   -9.78599  1.000 29.26304  ? 352 ALA A HB3  1 
ATOM   5248 N  N    . ASN A 1 361 ? 12.52036  9.45537   -7.81410  1.000 29.20818  ? 353 ASN A N    1 
ATOM   5249 C  CA   . ASN A 1 361 ? 13.69529  9.68545   -6.98273  1.000 25.05889  ? 353 ASN A CA   1 
ATOM   5250 C  C    . ASN A 1 361 ? 13.98802  8.39687   -6.22300  1.000 19.58038  ? 353 ASN A C    1 
ATOM   5251 O  O    . ASN A 1 361 ? 13.13943  7.90652   -5.47109  1.000 24.88676  ? 353 ASN A O    1 
ATOM   5252 C  CB   . ASN A 1 361 ? 13.44894  10.84809  -6.02309  1.000 24.28780  ? 353 ASN A CB   1 
ATOM   5253 C  CG   . ASN A 1 361 ? 13.29379  12.18451  -6.74534  1.000 27.74677  ? 353 ASN A CG   1 
ATOM   5254 O  OD1  . ASN A 1 361 ? 13.97191  12.44892  -7.73172  1.000 21.73372  ? 353 ASN A OD1  1 
ATOM   5255 N  ND2  . ASN A 1 361 ? 12.41204  13.03614  -6.24071  1.000 22.82487  ? 353 ASN A ND2  1 
ATOM   5256 H  H    . ASN A 1 361 ? 11.78112  9.54159   -7.38317  1.000 35.02663  ? 353 ASN A H    1 
ATOM   5257 H  HA   . ASN A 1 361 ? 14.46547  9.90799   -7.52880  1.000 30.04748  ? 353 ASN A HA   1 
ATOM   5258 H  HB2  . ASN A 1 361 ? 12.63403  10.67973  -5.52461  1.000 29.12217  ? 353 ASN A HB2  1 
ATOM   5259 H  HB3  . ASN A 1 361 ? 14.20091  10.92103  -5.41471  1.000 29.12217  ? 353 ASN A HB3  1 
ATOM   5260 H  HD21 . ASN A 1 361 ? 12.29078  13.80125  -6.61422  1.000 27.36665  ? 353 ASN A HD21 1 
ATOM   5261 H  HD22 . ASN A 1 361 ? 11.96130  12.82352  -5.53985  1.000 27.36665  ? 353 ASN A HD22 1 
ATOM   5262 N  N    . VAL A 1 362 ? 15.17907  7.85393   -6.41759  1.000 19.06024  ? 354 VAL A N    1 
ATOM   5263 C  CA   . VAL A 1 362 ? 15.46568  6.46164   -6.10573  1.000 20.33996  ? 354 VAL A CA   1 
ATOM   5264 C  C    . VAL A 1 362 ? 16.41264  6.36044   -4.92080  1.000 24.87277  ? 354 VAL A C    1 
ATOM   5265 O  O    . VAL A 1 362 ? 17.43196  7.06020   -4.85852  1.000 20.38046  ? 354 VAL A O    1 
ATOM   5266 C  CB   . VAL A 1 362 ? 16.07365  5.75481   -7.33134  1.000 24.21038  ? 354 VAL A CB   1 
ATOM   5267 C  CG1  . VAL A 1 362 ? 16.47954  4.31653   -6.98842  1.000 22.19364  ? 354 VAL A CG1  1 
ATOM   5268 C  CG2  . VAL A 1 362 ? 15.10217  5.78533   -8.52547  1.000 18.55102  ? 354 VAL A CG2  1 
ATOM   5269 H  H    . VAL A 1 362 ? 15.85354  8.28151   -6.73676  1.000 22.84910  ? 354 VAL A H    1 
ATOM   5270 H  HA   . VAL A 1 362 ? 14.63677  6.03021   -5.84558  1.000 24.38477  ? 354 VAL A HA   1 
ATOM   5271 H  HB   . VAL A 1 362 ? 16.87554  6.23366   -7.59321  1.000 29.02927  ? 354 VAL A HB   1 
ATOM   5272 H  HG11 . VAL A 1 362 ? 16.76379  3.86672   -7.79945  1.000 26.60918  ? 354 VAL A HG11 1 
ATOM   5273 H  HG12 . VAL A 1 362 ? 17.20879  4.33808   -6.34917  1.000 26.60918  ? 354 VAL A HG12 1 
ATOM   5274 H  HG13 . VAL A 1 362 ? 15.71684  3.85611   -6.60475  1.000 26.60918  ? 354 VAL A HG13 1 
ATOM   5275 H  HG21 . VAL A 1 362 ? 15.50676  5.31918   -9.27374  1.000 22.23803  ? 354 VAL A HG21 1 
ATOM   5276 H  HG22 . VAL A 1 362 ? 14.27504  5.34717   -8.27095  1.000 22.23803  ? 354 VAL A HG22 1 
ATOM   5277 H  HG23 . VAL A 1 362 ? 14.92692  6.70842   -8.76650  1.000 22.23803  ? 354 VAL A HG23 1 
ATOM   5278 N  N    . ILE A 1 363 ? 16.09432  5.44301   -4.00918  1.000 23.31630  ? 355 ILE A N    1 
ATOM   5279 C  CA   . ILE A 1 363 ? 16.98520  5.02586   -2.93202  1.000 18.83857  ? 355 ILE A CA   1 
ATOM   5280 C  C    . ILE A 1 363 ? 17.26139  3.53732   -3.10888  1.000 21.89786  ? 355 ILE A C    1 
ATOM   5281 O  O    . ILE A 1 363 ? 16.32525  2.74622   -3.27417  1.000 17.94582  ? 355 ILE A O    1 
ATOM   5282 C  CB   . ILE A 1 363 ? 16.38311  5.29396   -1.53943  1.000 16.24169  ? 355 ILE A CB   1 
ATOM   5283 C  CG1  . ILE A 1 363 ? 15.83435  6.71381   -1.44572  1.000 18.21238  ? 355 ILE A CG1  1 
ATOM   5284 C  CG2  . ILE A 1 363 ? 17.43662  5.02656   -0.45996  1.000 15.96630  ? 355 ILE A CG2  1 
ATOM   5285 C  CD1  . ILE A 1 363 ? 16.91693  7.79616   -1.41685  1.000 21.77071  ? 355 ILE A CD1  1 
ATOM   5286 H  H    . ILE A 1 363 ? 15.33822  5.03349   -3.99514  1.000 27.95637  ? 355 ILE A H    1 
ATOM   5287 H  HA   . ILE A 1 363 ? 17.81782  5.51874   -3.00063  1.000 22.58310  ? 355 ILE A HA   1 
ATOM   5288 H  HB   . ILE A 1 363 ? 15.63752  4.68943   -1.39965  1.000 19.46684  ? 355 ILE A HB   1 
ATOM   5289 H  HG12 . ILE A 1 363 ? 15.26983  6.88098   -2.21661  1.000 21.83167  ? 355 ILE A HG12 1 
ATOM   5290 H  HG13 . ILE A 1 363 ? 15.31481  6.79368   -0.63049  1.000 21.83167  ? 355 ILE A HG13 1 
ATOM   5291 H  HG21 . ILE A 1 363 ? 17.06176  5.24391   0.40787   1.000 19.13637  ? 355 ILE A HG21 1 
ATOM   5292 H  HG22 . ILE A 1 363 ? 17.68598  4.08956   -0.48730  1.000 19.13637  ? 355 ILE A HG22 1 
ATOM   5293 H  HG23 . ILE A 1 363 ? 18.21366  5.58083   -0.63286  1.000 19.13637  ? 355 ILE A HG23 1 
ATOM   5294 H  HD11 . ILE A 1 363 ? 16.49173  8.66796   -1.40855  1.000 26.10166  ? 355 ILE A HD11 1 
ATOM   5295 H  HD12 . ILE A 1 363 ? 17.45530  7.68309   -0.61793  1.000 26.10166  ? 355 ILE A HD12 1 
ATOM   5296 H  HD13 . ILE A 1 363 ? 17.47362  7.70714   -2.20619  1.000 26.10166  ? 355 ILE A HD13 1 
ATOM   5297 N  N    . ASN A 1 364 ? 18.53876  3.15247   -3.06360  1.000 15.72447  ? 356 ASN A N    1 
ATOM   5298 C  CA   . ASN A 1 364 ? 18.95372  1.76559   -3.26873  1.000 15.43609  ? 356 ASN A CA   1 
ATOM   5299 C  C    . ASN A 1 364 ? 19.46788  1.20723   -1.94580  1.000 17.24165  ? 356 ASN A C    1 
ATOM   5300 O  O    . ASN A 1 364 ? 20.55880  1.56470   -1.48728  1.000 16.00254  ? 356 ASN A O    1 
ATOM   5301 C  CB   . ASN A 1 364 ? 20.01226  1.67626   -4.36803  1.000 18.61322  ? 356 ASN A CB   1 
ATOM   5302 C  CG   . ASN A 1 364 ? 19.45286  2.01905   -5.74746  1.000 18.83889  ? 356 ASN A CG   1 
ATOM   5303 O  OD1  . ASN A 1 364 ? 19.59077  3.13443   -6.24707  1.000 23.44725  ? 356 ASN A OD1  1 
ATOM   5304 N  ND2  . ASN A 1 364 ? 18.80422  1.05944   -6.35361  1.000 21.11417  ? 356 ASN A ND2  1 
ATOM   5305 H  H    . ASN A 1 364 ? 19.19421  3.68836   -2.91260  1.000 18.84617  ? 356 ASN A H    1 
ATOM   5306 H  HA   . ASN A 1 364 ? 18.18779  1.23436   -3.53713  1.000 18.50012  ? 356 ASN A HA   1 
ATOM   5307 H  HB2  . ASN A 1 364 ? 20.72835  2.29991   -4.17012  1.000 22.31268  ? 356 ASN A HB2  1 
ATOM   5308 H  HB3  . ASN A 1 364 ? 20.35999  0.77131   -4.40060  1.000 22.31268  ? 356 ASN A HB3  1 
ATOM   5309 H  HD21 . ASN A 1 364 ? 18.46671  1.19413   -7.13307  1.000 25.31381  ? 356 ASN A HD21 1 
ATOM   5310 H  HD22 . ASN A 1 364 ? 18.71501  0.29347   -5.97291  1.000 25.31381  ? 356 ASN A HD22 1 
ATOM   5311 N  N    . ILE A 1 365 ? 18.68803  0.31920   -1.34836  1.000 13.86565  ? 357 ILE A N    1 
ATOM   5312 C  CA   . ILE A 1 365 ? 18.98997  -0.24007  -0.03773  1.000 19.79488  ? 357 ILE A CA   1 
ATOM   5313 C  C    . ILE A 1 365 ? 19.31493  -1.72804  -0.17488  1.000 16.01973  ? 357 ILE A C    1 
ATOM   5314 O  O    . ILE A 1 365 ? 18.69832  -2.46538  -0.95908  1.000 18.12336  ? 357 ILE A O    1 
ATOM   5315 C  CB   . ILE A 1 365 ? 17.81830  -0.03316  0.94710   1.000 11.13652  ? 357 ILE A CB   1 
ATOM   5316 C  CG1  . ILE A 1 365 ? 17.50697  1.44538   1.14230   1.000 17.93397  ? 357 ILE A CG1  1 
ATOM   5317 C  CG2  . ILE A 1 365 ? 18.11145  -0.69645  2.29626   1.000 13.26202  ? 357 ILE A CG2  1 
ATOM   5318 C  CD1  . ILE A 1 365 ? 16.21160  1.71700   1.86791   1.000 15.74588  ? 357 ILE A CD1  1 
ATOM   5319 H  H    . ILE A 1 365 ? 17.95921  0.01641   -1.69006  1.000 16.61560  ? 357 ILE A H    1 
ATOM   5320 H  HA   . ILE A 1 365 ? 19.77833  0.20336   0.31261   1.000 23.73067  ? 357 ILE A HA   1 
ATOM   5321 H  HB   . ILE A 1 365 ? 17.03825  -0.45594  0.55508   1.000 13.34064  ? 357 ILE A HB   1 
ATOM   5322 H  HG12 . ILE A 1 365 ? 18.22288  1.84709   1.65902   1.000 21.49757  ? 357 ILE A HG12 1 
ATOM   5323 H  HG13 . ILE A 1 365 ? 17.44957  1.86752   0.27086   1.000 21.49757  ? 357 ILE A HG13 1 
ATOM   5324 H  HG21 . ILE A 1 365 ? 17.37615  -0.51684  2.90287   1.000 15.89123  ? 357 ILE A HG21 1 
ATOM   5325 H  HG22 . ILE A 1 365 ? 18.20527  -1.65283  2.16422   1.000 15.89123  ? 357 ILE A HG22 1 
ATOM   5326 H  HG23 . ILE A 1 365 ? 18.93427  -0.32995  2.65619   1.000 15.89123  ? 357 ILE A HG23 1 
ATOM   5327 H  HD11 . ILE A 1 365 ? 16.06891  2.67547   1.91132   1.000 18.87187  ? 357 ILE A HD11 1 
ATOM   5328 H  HD12 . ILE A 1 365 ? 15.48414  1.29587   1.38382   1.000 18.87187  ? 357 ILE A HD12 1 
ATOM   5329 H  HD13 . ILE A 1 365 ? 16.26868  1.35016   2.76405   1.000 18.87187  ? 357 ILE A HD13 1 
ATOM   5330 N  N    . SER A 1 366 ? 20.25176  -2.18415  0.64791   1.000 17.94449  ? 358 SER A N    1 
ATOM   5331 C  CA   . SER A 1 366 ? 20.66163  -3.58061  0.62171   1.000 17.60813  ? 358 SER A CA   1 
ATOM   5332 C  C    . SER A 1 366 ? 20.77445  -4.13339  2.03533   1.000 24.92369  ? 358 SER A C    1 
ATOM   5333 O  O    . SER A 1 366 ? 21.19012  -3.42321  2.95357   1.000 22.54019  ? 358 SER A O    1 
ATOM   5334 C  CB   . SER A 1 366 ? 22.01093  -3.75848  -0.08932  1.000 21.16672  ? 358 SER A CB   1 
ATOM   5335 O  OG   . SER A 1 366 ? 21.99581  -3.17159  -1.37325  1.000 26.28503  ? 358 SER A OG   1 
ATOM   5336 H  H    . SER A 1 366 ? 20.66409  -1.70362  1.22986   1.000 21.51020  ? 358 SER A H    1 
ATOM   5337 H  HA   . SER A 1 366 ? 19.98097  -4.08789  0.15238   1.000 21.10657  ? 358 SER A HA   1 
ATOM   5338 H  HB2  . SER A 1 366 ? 22.70358  -3.33474  0.44132   1.000 25.37687  ? 358 SER A HB2  1 
ATOM   5339 H  HB3  . SER A 1 366 ? 22.19551  -4.70645  -0.17970  1.000 25.37687  ? 358 SER A HB3  1 
ATOM   5340 H  HG   . SER A 1 366 ? 21.26996  -3.34385  -1.75934  1.000 31.51885  ? 358 SER A HG   1 
ATOM   5341 N  N    . TRP A 1 367 ? 20.38254  -5.40002  2.20978   1.000 17.14640  ? 359 TRP A N    1 
ATOM   5342 C  CA   . TRP A 1 367 ? 20.65394  -6.09101  3.46836   1.000 19.88963  ? 359 TRP A CA   1 
ATOM   5343 C  C    . TRP A 1 367 ? 22.15351  -6.23575  3.70296   1.000 23.24498  ? 359 TRP A C    1 
ATOM   5344 O  O    . TRP A 1 367 ? 22.65659  -5.95291  4.79917   1.000 20.38599  ? 359 TRP A O    1 
ATOM   5345 C  CB   . TRP A 1 367 ? 20.01892  -7.47836  3.46918   1.000 18.13712  ? 359 TRP A CB   1 
ATOM   5346 C  CG   . TRP A 1 367 ? 18.54420  -7.51233  3.32205   1.000 25.54607  ? 359 TRP A CG   1 
ATOM   5347 C  CD1  . TRP A 1 367 ? 17.70258  -6.45384  3.10599   1.000 26.40857  ? 359 TRP A CD1  1 
ATOM   5348 C  CD2  . TRP A 1 367 ? 17.71219  -8.67854  3.38751   1.000 19.03855  ? 359 TRP A CD2  1 
ATOM   5349 N  NE1  . TRP A 1 367 ? 16.39898  -6.89842  3.01815   1.000 26.45264  ? 359 TRP A NE1  1 
ATOM   5350 C  CE2  . TRP A 1 367 ? 16.37836  -8.25620  3.19594   1.000 23.54584  ? 359 TRP A CE2  1 
ATOM   5351 C  CE3  . TRP A 1 367 ? 17.96618  -10.03837 3.56957   1.000 24.12302  ? 359 TRP A CE3  1 
ATOM   5352 C  CZ2  . TRP A 1 367 ? 15.30314  -9.14376  3.18493   1.000 17.51138  ? 359 TRP A CZ2  1 
ATOM   5353 C  CZ3  . TRP A 1 367 ? 16.89411  -10.91700 3.55587   1.000 25.22246  ? 359 TRP A CZ3  1 
ATOM   5354 C  CH2  . TRP A 1 367 ? 15.57847  -10.46247 3.36538   1.000 25.26951  ? 359 TRP A CH2  1 
ATOM   5355 H  H    . TRP A 1 367 ? 19.96527  -5.87174  1.62414   1.000 20.55249  ? 359 TRP A H    1 
ATOM   5356 H  HA   . TRP A 1 367 ? 20.26268  -5.56556  4.18370   1.000 23.84437  ? 359 TRP A HA   1 
ATOM   5357 H  HB2  . TRP A 1 367 ? 20.39305  -7.98449  2.73110   1.000 21.74135  ? 359 TRP A HB2  1 
ATOM   5358 H  HB3  . TRP A 1 367 ? 20.23377  -7.91064  4.31053   1.000 21.74135  ? 359 TRP A HB3  1 
ATOM   5359 H  HD1  . TRP A 1 367 ? 17.97001  -5.56639  3.02971   1.000 31.66709  ? 359 TRP A HD1  1 
ATOM   5360 H  HE1  . TRP A 1 367 ? 15.71083  -6.40290  2.87492   1.000 31.71998  ? 359 TRP A HE1  1 
ATOM   5361 H  HE3  . TRP A 1 367 ? 18.83387  -10.34782 3.69704   1.000 28.92443  ? 359 TRP A HE3  1 
ATOM   5362 H  HZ2  . TRP A 1 367 ? 14.43146  -8.84509  3.05901   1.000 20.99046  ? 359 TRP A HZ2  1 
ATOM   5363 H  HZ3  . TRP A 1 367 ? 17.04897  -11.82621 3.67524   1.000 30.24376  ? 359 TRP A HZ3  1 
ATOM   5364 H  HH2  . TRP A 1 367 ? 14.88072  -11.07732 3.36270   1.000 30.30022  ? 359 TRP A HH2  1 
ATOM   5365 N  N    . LEU A 1 368 ? 22.88436  -6.68184  2.67314   1.000 20.51047  ? 360 LEU A N    1 
ATOM   5366 C  CA   . LEU A 1 368 ? 24.28755  -7.04746  2.79579   1.000 18.05708  ? 360 LEU A CA   1 
ATOM   5367 C  C    . LEU A 1 368 ? 25.10534  -6.42946  1.67209   1.000 20.88617  ? 360 LEU A C    1 
ATOM   5368 O  O    . LEU A 1 368 ? 24.69445  -6.44702  0.50902   1.000 27.62430  ? 360 LEU A O    1 
ATOM   5369 C  CB   . LEU A 1 368 ? 24.43219  -8.56358  2.77000   1.000 24.10782  ? 360 LEU A CB   1 
ATOM   5370 C  CG   . LEU A 1 368 ? 23.59222  -9.31074  3.80622   1.000 23.78951  ? 360 LEU A CG   1 
ATOM   5371 C  CD1  . LEU A 1 368 ? 23.57508  -10.79974 3.55088   1.000 30.68253  ? 360 LEU A CD1  1 
ATOM   5372 C  CD2  . LEU A 1 368 ? 24.14938  -9.01801  5.18296   1.000 27.26821  ? 360 LEU A CD2  1 
ATOM   5373 H  H    . LEU A 1 368 ? 22.57526  -6.78114  1.87678   1.000 24.58938  ? 360 LEU A H    1 
ATOM   5374 H  HA   . LEU A 1 368 ? 24.64428  -6.70014  3.62827   1.000 21.64531  ? 360 LEU A HA   1 
ATOM   5375 H  HB2  . LEU A 1 368 ? 24.16471  -8.88190  1.89363   1.000 28.90620  ? 360 LEU A HB2  1 
ATOM   5376 H  HB3  . LEU A 1 368 ? 25.36216  -8.78536  2.93392   1.000 28.90620  ? 360 LEU A HB3  1 
ATOM   5377 H  HG   . LEU A 1 368 ? 22.67192  -9.00944  3.74989   1.000 28.52422  ? 360 LEU A HG   1 
ATOM   5378 H  HD11 . LEU A 1 368 ? 23.04408  -11.23190 4.23803   1.000 36.79585  ? 360 LEU A HD11 1 
ATOM   5379 H  HD12 . LEU A 1 368 ? 23.18547  -10.96605 2.67828   1.000 36.79585  ? 360 LEU A HD12 1 
ATOM   5380 H  HD13 . LEU A 1 368 ? 24.48495  -11.13498 3.57622   1.000 36.79585  ? 360 LEU A HD13 1 
ATOM   5381 H  HD21 . LEU A 1 368 ? 23.61292  -9.48054  5.84565   1.000 32.69866  ? 360 LEU A HD21 1 
ATOM   5382 H  HD22 . LEU A 1 368 ? 25.06726  -9.32891  5.22483   1.000 32.69866  ? 360 LEU A HD22 1 
ATOM   5383 H  HD23 . LEU A 1 368 ? 24.11669  -8.06137  5.34001   1.000 32.69866  ? 360 LEU A HD23 1 
ATOM   5384 N  N    . LYS A 1 369 ? 26.25569  -5.86915  2.03328   1.000 22.98796  ? 361 LYS A N    1 
ATOM   5385 C  CA   . LYS A 1 369 ? 27.22752  -5.35541  1.07718   1.000 24.76047  ? 361 LYS A CA   1 
ATOM   5386 C  C    . LYS A 1 369 ? 28.45622  -6.26010  1.10054   1.000 20.59945  ? 361 LYS A C    1 
ATOM   5387 O  O    . LYS A 1 369 ? 29.08446  -6.42743  2.14965   1.000 21.43262  ? 361 LYS A O    1 
ATOM   5388 C  CB   . LYS A 1 369 ? 27.61150  -3.91207  1.41157   1.000 26.65198  ? 361 LYS A CB   1 
ATOM   5389 C  CG   . LYS A 1 369 ? 28.70475  -3.32491  0.51107   1.000 27.62114  ? 361 LYS A CG   1 
ATOM   5390 C  CD   . LYS A 1 369 ? 28.22491  -3.15228  -0.93300  1.000 29.31744  ? 361 LYS A CD   1 
ATOM   5391 C  CE   . LYS A 1 369 ? 29.39633  -3.00414  -1.89717  1.000 29.43439  ? 361 LYS A CE   1 
ATOM   5392 N  NZ   . LYS A 1 369 ? 30.15142  -4.26863  -2.09731  1.000 20.86841  ? 361 LYS A NZ   1 
ATOM   5393 H  H    . LYS A 1 369 ? 26.50153  -5.77313  2.85178   1.000 27.56236  ? 361 LYS A H    1 
ATOM   5394 H  HA   . LYS A 1 369 ? 26.84929  -5.37057  0.18408   1.000 29.68938  ? 361 LYS A HA   1 
ATOM   5395 H  HB2  . LYS A 1 369 ? 26.82404  -3.35307  1.32025   1.000 31.95918  ? 361 LYS A HB2  1 
ATOM   5396 H  HB3  . LYS A 1 369 ? 27.93577  -3.88168  2.32526   1.000 31.95918  ? 361 LYS A HB3  1 
ATOM   5397 H  HG2  . LYS A 1 369 ? 28.96464  -2.45406  0.85017   1.000 33.12218  ? 361 LYS A HG2  1 
ATOM   5398 H  HG3  . LYS A 1 369 ? 29.46984  -3.92116  0.50692   1.000 33.12218  ? 361 LYS A HG3  1 
ATOM   5399 H  HD2  . LYS A 1 369 ? 27.71038  -3.93140  -1.19589  1.000 35.15774  ? 361 LYS A HD2  1 
ATOM   5400 H  HD3  . LYS A 1 369 ? 27.67564  -2.35526  -0.99593  1.000 35.15774  ? 361 LYS A HD3  1 
ATOM   5401 H  HE2  . LYS A 1 369 ? 29.05922  -2.71836  -2.76064  1.000 35.29808  ? 361 LYS A HE2  1 
ATOM   5402 H  HE3  . LYS A 1 369 ? 30.01172  -2.34190  -1.54556  1.000 35.29808  ? 361 LYS A HE3  1 
ATOM   5403 H  HZ1  . LYS A 1 369 ? 30.86599  -4.11915  -2.60637  1.000 25.01890  ? 361 LYS A HZ1  1 
ATOM   5404 H  HZ2  . LYS A 1 369 ? 30.41859  -4.59118  -1.31202  1.000 25.01890  ? 361 LYS A HZ2  1 
ATOM   5405 H  HZ3  . LYS A 1 369 ? 29.63361  -4.87245  -2.49651  1.000 25.01890  ? 361 LYS A HZ3  1 
ATOM   5406 N  N    . THR A 1 370 ? 28.79733  -6.83382  -0.05291  1.000 25.15957  ? 362 THR A N    1 
ATOM   5407 C  CA   . THR A 1 370 ? 30.00430  -7.64879  -0.15998  1.000 25.12732  ? 362 THR A CA   1 
ATOM   5408 C  C    . THR A 1 370 ? 31.25299  -6.80555  0.08832   1.000 22.95129  ? 362 THR A C    1 
ATOM   5409 O  O    . THR A 1 370 ? 31.40232  -5.70683  -0.46076  1.000 23.78053  ? 362 THR A O    1 
ATOM   5410 C  CB   . THR A 1 370 ? 30.07995  -8.29863  -1.54131  1.000 32.24186  ? 362 THR A CB   1 
ATOM   5411 O  OG1  . THR A 1 370 ? 28.81725  -8.89554  -1.86647  1.000 26.66475  ? 362 THR A OG1  1 
ATOM   5412 C  CG2  . THR A 1 370 ? 31.17171  -9.36366  -1.57971  1.000 30.07929  ? 362 THR A CG2  1 
ATOM   5413 H  H    . THR A 1 370 ? 28.34918  -6.76684  -0.78385  1.000 30.16830  ? 362 THR A H    1 
ATOM   5414 H  HA   . THR A 1 370 ? 29.97116  -8.34922  0.51025   1.000 30.12960  ? 362 THR A HA   1 
ATOM   5415 H  HB   . THR A 1 370 ? 30.29455  -7.62146  -2.20183  1.000 38.66705  ? 362 THR A HB   1 
ATOM   5416 H  HG1  . THR A 1 370 ? 28.72215  -8.93032  -2.70034  1.000 31.97450  ? 362 THR A HG1  1 
ATOM   5417 H  HG21 . THR A 1 370 ? 31.19356  -9.78502  -2.45314  1.000 36.07196  ? 362 THR A HG21 1 
ATOM   5418 H  HG22 . THR A 1 370 ? 32.03573  -8.95956  -1.40344  1.000 36.07196  ? 362 THR A HG22 1 
ATOM   5419 H  HG23 . THR A 1 370 ? 30.99805  -10.04117 -0.90761  1.000 36.07196  ? 362 THR A HG23 1 
ATOM   5420 N  N    . ILE A 1 371 ? 32.15809  -7.32267  0.92170   1.000 23.17178  ? 363 ILE A N    1 
ATOM   5421 C  CA   . ILE A 1 371 ? 33.32023  -6.52874  1.30039   1.000 31.61564  ? 363 ILE A CA   1 
ATOM   5422 C  C    . ILE A 1 371 ? 34.29525  -6.46024  0.13299   1.000 35.12819  ? 363 ILE A C    1 
ATOM   5423 O  O    . ILE A 1 371 ? 34.39238  -7.38806  -0.68200  1.000 24.00500  ? 363 ILE A O    1 
ATOM   5424 C  CB   . ILE A 1 371 ? 34.00977  -7.08392  2.56011   1.000 25.43075  ? 363 ILE A CB   1 
ATOM   5425 C  CG1  . ILE A 1 371 ? 34.66711  -8.42417  2.26783   1.000 32.66951  ? 363 ILE A CG1  1 
ATOM   5426 C  CG2  . ILE A 1 371 ? 33.00122  -7.21991  3.70137   1.000 28.41830  ? 363 ILE A CG2  1 
ATOM   5427 C  CD1  . ILE A 1 371 ? 35.64476  -8.87635  3.36087   1.000 33.15666  ? 363 ILE A CD1  1 
ATOM   5428 H  H    . ILE A 1 371 ? 32.12108  -8.10807  1.27010   1.000 27.78295  ? 363 ILE A H    1 
ATOM   5429 H  HA   . ILE A 1 371 ? 33.01540  -5.63214  1.51035   1.000 37.91558  ? 363 ILE A HA   1 
ATOM   5430 H  HB   . ILE A 1 371 ? 34.70132  -6.45852  2.82759   1.000 30.49372  ? 363 ILE A HB   1 
ATOM   5431 H  HG12 . ILE A 1 371 ? 33.97660  -9.10074  2.18811   1.000 39.18022  ? 363 ILE A HG12 1 
ATOM   5432 H  HG13 . ILE A 1 371 ? 35.16184  -8.35548  1.43631   1.000 39.18022  ? 363 ILE A HG13 1 
ATOM   5433 H  HG21 . ILE A 1 371 ? 33.46499  -7.52054  4.49851   1.000 34.07877  ? 363 ILE A HG21 1 
ATOM   5434 H  HG22 . ILE A 1 371 ? 32.58981  -6.35662  3.86379   1.000 34.07877  ? 363 ILE A HG22 1 
ATOM   5435 H  HG23 . ILE A 1 371 ? 32.32397  -7.86682  3.44890   1.000 34.07877  ? 363 ILE A HG23 1 
ATOM   5436 H  HD11 . ILE A 1 371 ? 36.05414  -9.71354  3.09175   1.000 39.76480  ? 363 ILE A HD11 1 
ATOM   5437 H  HD12 . ILE A 1 371 ? 36.32694  -8.19634  3.47540   1.000 39.76480  ? 363 ILE A HD12 1 
ATOM   5438 H  HD13 . ILE A 1 371 ? 35.15677  -8.99833  4.19026   1.000 39.76480  ? 363 ILE A HD13 1 
ATOM   5439 N  N    . ASN A 1 372 ? 35.02271  -5.34060  0.04894   1.000 35.10032  ? 364 ASN A N    1 
ATOM   5440 C  CA   . ASN A 1 372 ? 36.07879  -5.15721  -0.94696  1.000 39.09293  ? 364 ASN A CA   1 
ATOM   5441 C  C    . ASN A 1 372 ? 35.55400  -5.36570  -2.36297  1.000 34.76628  ? 364 ASN A C    1 
ATOM   5442 O  O    . ASN A 1 372 ? 36.21076  -5.97999  -3.20104  1.000 40.57422  ? 364 ASN A O    1 
ATOM   5443 C  CB   . ASN A 1 372 ? 37.25750  -6.08875  -0.66628  1.000 34.31869  ? 364 ASN A CB   1 
ATOM   5444 C  CG   . ASN A 1 372 ? 37.76821  -5.95459  0.74561   1.000 33.34249  ? 364 ASN A CG   1 
ATOM   5445 O  OD1  . ASN A 1 372 ? 37.75923  -4.85940  1.31787   1.000 40.37884  ? 364 ASN A OD1  1 
ATOM   5446 N  ND2  . ASN A 1 372 ? 38.21644  -7.06432  1.32218   1.000 36.93074  ? 364 ASN A ND2  1 
ATOM   5447 H  H    . ASN A 1 372 ? 34.91996  -4.66239  0.56767   1.000 42.09720  ? 364 ASN A H    1 
ATOM   5448 H  HA   . ASN A 1 372 ? 36.39373  -4.24151  -0.89039  1.000 46.88833  ? 364 ASN A HA   1 
ATOM   5449 H  HB2  . ASN A 1 372 ? 36.97555  -7.00727  -0.79942  1.000 41.15924  ? 364 ASN A HB2  1 
ATOM   5450 H  HB3  . ASN A 1 372 ? 37.98401  -5.87362  -1.27192  1.000 41.15924  ? 364 ASN A HB3  1 
ATOM   5451 H  HD21 . ASN A 1 372 ? 38.51814  -7.03901  2.12713   1.000 44.29370  ? 364 ASN A HD21 1 
ATOM   5452 H  HD22 . ASN A 1 372 ? 38.20491  -7.80803  0.89048   1.000 44.29370  ? 364 ASN A HD22 1 
ATOM   5453 N  N    . ARG A 1 373 ? 34.36082  -4.84894  -2.63413  1.000 34.87417  ? 365 ARG A N    1 
ATOM   5454 C  CA   . ARG A 1 373 ? 33.80187  -4.81089  -3.97899  1.000 36.33676  ? 365 ARG A CA   1 
ATOM   5455 C  C    . ARG A 1 373 ? 33.20229  -3.42950  -4.18512  1.000 36.60416  ? 365 ARG A C    1 
ATOM   5456 O  O    . ARG A 1 373 ? 32.41563  -2.96700  -3.35424  1.000 36.25301  ? 365 ARG A O    1 
ATOM   5457 C  CB   . ARG A 1 373 ? 32.73345  -5.89329  -4.19592  1.000 28.90620  ? 365 ARG A CB   1 
ATOM   5458 C  CG   . ARG A 1 373 ? 33.24844  -7.31449  -4.12450  1.000 39.63720  ? 365 ARG A CG   1 
ATOM   5459 C  CD   . ARG A 1 373 ? 34.25443  -7.61782  -5.22904  1.000 39.02185  ? 365 ARG A CD   1 
ATOM   5460 N  NE   . ARG A 1 373 ? 33.61632  -7.90298  -6.51493  1.000 44.77357  ? 365 ARG A NE   1 
ATOM   5461 C  CZ   . ARG A 1 373 ? 33.04538  -9.06311  -6.83374  1.000 62.67904  ? 365 ARG A CZ   1 
ATOM   5462 N  NH1  . ARG A 1 373 ? 33.02332  -10.05823 -5.95242  1.000 46.31052  ? 365 ARG A NH1  1 
ATOM   5463 N  NH2  . ARG A 1 373 ? 32.49571  -9.22895  -8.03610  1.000 45.27440  ? 365 ARG A NH2  1 
ATOM   5464 H  H    . ARG A 1 373 ? 33.84309  -4.50539  -2.03955  1.000 41.82581  ? 365 ARG A H    1 
ATOM   5465 H  HA   . ARG A 1 373 ? 34.50148  -4.96704  -4.63249  1.000 43.58093  ? 365 ARG A HA   1 
ATOM   5466 H  HB2  . ARG A 1 373 ? 32.05214  -5.79492  -3.51251  1.000 34.66425  ? 365 ARG A HB2  1 
ATOM   5467 H  HB3  . ARG A 1 373 ? 32.34233  -5.76827  -5.07472  1.000 34.66425  ? 365 ARG A HB3  1 
ATOM   5468 H  HG2  . ARG A 1 373 ? 33.68707  -7.45207  -3.27034  1.000 47.54145  ? 365 ARG A HG2  1 
ATOM   5469 H  HG3  . ARG A 1 373 ? 32.50337  -7.92859  -4.21755  1.000 47.54145  ? 365 ARG A HG3  1 
ATOM   5470 H  HD2  . ARG A 1 373 ? 34.83563  -6.85020  -5.34676  1.000 46.80303  ? 365 ARG A HD2  1 
ATOM   5471 H  HD3  . ARG A 1 373 ? 34.77761  -8.39430  -4.97556  1.000 46.80303  ? 365 ARG A HD3  1 
ATOM   5472 H  HE   . ARG A 1 373 ? 33.60959  -7.27798  -7.10565  1.000 53.70510  ? 365 ARG A HE   1 
ATOM   5473 H  HH11 . ARG A 1 373 ? 33.37785  -9.95293  -5.17601  1.000 55.54944  ? 365 ARG A HH11 1 
ATOM   5474 H  HH12 . ARG A 1 373 ? 32.65451  -10.80724 -6.15873  1.000 55.54944  ? 365 ARG A HH12 1 
ATOM   5475 H  HH21 . ARG A 1 373 ? 32.50933  -8.58633  -8.60747  1.000 54.30609  ? 365 ARG A HH21 1 
ATOM   5476 H  HH22 . ARG A 1 373 ? 32.12731  -9.97860  -8.24080  1.000 54.30609  ? 365 ARG A HH22 1 
ATOM   5477 N  N    . ASP A 1 374 ? 33.58551  -2.76755  -5.27214  1.000 31.61644  ? 366 ASP A N    1 
ATOM   5478 C  CA   . ASP A 1 374 ? 33.12498  -1.41620  -5.55821  1.000 27.55181  ? 366 ASP A CA   1 
ATOM   5479 C  C    . ASP A 1 374 ? 31.84908  -1.44076  -6.39599  1.000 26.58945  ? 366 ASP A C    1 
ATOM   5480 O  O    . ASP A 1 374 ? 31.59302  -2.37492  -7.15730  1.000 30.67190  ? 366 ASP A O    1 
ATOM   5481 C  CB   . ASP A 1 374 ? 34.21972  -0.62540  -6.28226  1.000 40.42424  ? 366 ASP A CB   1 
ATOM   5482 C  CG   . ASP A 1 374 ? 35.47676  -0.45572  -5.43606  1.000 44.89918  ? 366 ASP A CG   1 
ATOM   5483 O  OD1  . ASP A 1 374 ? 35.54910  -1.05421  -4.33435  1.000 41.23927  ? 366 ASP A OD1  1 
ATOM   5484 O  OD2  . ASP A 1 374 ? 36.39040  0.27494   -5.87621  1.000 51.27762  ? 366 ASP A OD2  1 
ATOM   5485 H  H    . ASP A 1 374 ? 34.11938  -3.08521  -5.86684  1.000 37.91654  ? 366 ASP A H    1 
ATOM   5486 H  HA   . ASP A 1 374 ? 32.91939  -0.96168  -4.72632  1.000 33.03899  ? 366 ASP A HA   1 
ATOM   5487 H  HB2  . ASP A 1 374 ? 34.46527  -1.09531  -7.09453  1.000 48.48590  ? 366 ASP A HB2  1 
ATOM   5488 H  HB3  . ASP A 1 374 ? 33.88181  0.25762   -6.49906  1.000 48.48590  ? 366 ASP A HB3  1 
ATOM   5489 N  N    . VAL A 1 375 ? 31.04878  -0.39423  -6.25051  1.000 31.30383  ? 367 VAL A N    1 
ATOM   5490 C  CA   . VAL A 1 375 ? 29.80711  -0.24110  -6.99663  1.000 33.00493  ? 367 VAL A CA   1 
ATOM   5491 C  C    . VAL A 1 375 ? 30.08609  0.63969   -8.20639  1.000 34.33028  ? 367 VAL A C    1 
ATOM   5492 O  O    . VAL A 1 375 ? 30.48236  1.80357   -8.06124  1.000 32.34373  ? 367 VAL A O    1 
ATOM   5493 C  CB   . VAL A 1 375 ? 28.70269  0.36176   -6.11412  1.000 31.56085  ? 367 VAL A CB   1 
ATOM   5494 C  CG1  . VAL A 1 375 ? 27.45421  0.64507   -6.92883  1.000 21.80033  ? 367 VAL A CG1  1 
ATOM   5495 C  CG2  . VAL A 1 375 ? 28.40685  -0.56088  -4.93285  1.000 35.30083  ? 367 VAL A CG2  1 
ATOM   5496 H  H    . VAL A 1 375 ? 31.20729  0.25718   -5.71187  1.000 37.54141  ? 367 VAL A H    1 
ATOM   5497 H  HA   . VAL A 1 375 ? 29.50993  -1.10815  -7.31414  1.000 39.58272  ? 367 VAL A HA   1 
ATOM   5498 H  HB   . VAL A 1 375 ? 29.00863  1.21016   -5.75702  1.000 37.84983  ? 367 VAL A HB   1 
ATOM   5499 H  HG11 . VAL A 1 375 ? 26.75262  0.95399   -6.33448  1.000 26.13720  ? 367 VAL A HG11 1 
ATOM   5500 H  HG12 . VAL A 1 375 ? 27.65500  1.32874   -7.58700  1.000 26.13720  ? 367 VAL A HG12 1 
ATOM   5501 H  HG13 . VAL A 1 375 ? 27.17554  -0.17063  -7.37365  1.000 26.13720  ? 367 VAL A HG13 1 
ATOM   5502 H  HG21 . VAL A 1 375 ? 27.69218  -0.17535  -4.40227  1.000 42.33780  ? 367 VAL A HG21 1 
ATOM   5503 H  HG22 . VAL A 1 375 ? 28.13683  -1.42927  -5.27029  1.000 42.33780  ? 367 VAL A HG22 1 
ATOM   5504 H  HG23 . VAL A 1 375 ? 29.20810  -0.65014  -4.39346  1.000 42.33780  ? 367 VAL A HG23 1 
ATOM   5505 N  N    . SER A 1 376 ? 29.86571  0.09820   -9.39975  1.000 28.54375  ? 368 SER A N    1 
ATOM   5506 C  CA   . SER A 1 376 ? 30.01006  0.86649   -10.62807 1.000 28.19691  ? 368 SER A CA   1 
ATOM   5507 C  C    . SER A 1 376 ? 28.69341  1.56654   -10.93332 1.000 29.81407  ? 368 SER A C    1 
ATOM   5508 O  O    . SER A 1 376 ? 27.65917  0.90907   -11.08293 1.000 30.33711  ? 368 SER A O    1 
ATOM   5509 C  CB   . SER A 1 376 ? 30.41813  -0.03946  -11.78502 1.000 26.32757  ? 368 SER A CB   1 
ATOM   5510 O  OG   . SER A 1 376 ? 31.65521  -0.66031  -11.49458 1.000 38.31637  ? 368 SER A OG   1 
ATOM   5511 H  H    . SER A 1 376 ? 29.62964  -0.71942  -9.52371  1.000 34.22932  ? 368 SER A H    1 
ATOM   5512 H  HA   . SER A 1 376 ? 30.69935  1.53898   -10.51172 1.000 33.81310  ? 368 SER A HA   1 
ATOM   5513 H  HB2  . SER A 1 376 ? 29.74003  -0.72137  -11.91183 1.000 31.56989  ? 368 SER A HB2  1 
ATOM   5514 H  HB3  . SER A 1 376 ? 30.50864  0.49237   -12.59116 1.000 31.56989  ? 368 SER A HB3  1 
ATOM   5515 H  HG   . SER A 1 376 ? 31.88447  -1.15639  -12.13250 1.000 45.95645  ? 368 SER A HG   1 
ATOM   5516 N  N    . ILE A 1 377 ? 28.73188  2.89037   -11.02973 1.000 20.64117  ? 369 ILE A N    1 
ATOM   5517 C  CA   . ILE A 1 377 ? 27.54806  3.68556   -11.33658 1.000 25.33657  ? 369 ILE A CA   1 
ATOM   5518 C  C    . ILE A 1 377 ? 27.45365  3.86437   -12.84898 1.000 29.05482  ? 369 ILE A C    1 
ATOM   5519 O  O    . ILE A 1 377 ? 28.45255  4.16408   -13.51564 1.000 30.93741  ? 369 ILE A O    1 
ATOM   5520 C  CB   . ILE A 1 377 ? 27.60062  5.04450   -10.61616 1.000 29.52260  ? 369 ILE A CB   1 
ATOM   5521 C  CG1  . ILE A 1 377 ? 27.71505  4.85372   -9.09932  1.000 28.84967  ? 369 ILE A CG1  1 
ATOM   5522 C  CG2  . ILE A 1 377 ? 26.36736  5.90061   -10.94809 1.000 19.50245  ? 369 ILE A CG2  1 
ATOM   5523 C  CD1  . ILE A 1 377 ? 26.59111  4.03301   -8.49888  1.000 25.87684  ? 369 ILE A CD1  1 
ATOM   5524 H  H    . ILE A 1 377 ? 29.44410  3.35967   -10.91981 1.000 24.74622  ? 369 ILE A H    1 
ATOM   5525 H  HA   . ILE A 1 377 ? 26.75554  3.21256   -11.03811 1.000 30.38069  ? 369 ILE A HA   1 
ATOM   5526 H  HB   . ILE A 1 377 ? 28.39096  5.50869   -10.93365 1.000 35.40393  ? 369 ILE A HB   1 
ATOM   5527 H  HG12 . ILE A 1 377 ? 28.54967  4.39947   -8.90448  1.000 34.59641  ? 369 ILE A HG12 1 
ATOM   5528 H  HG13 . ILE A 1 377 ? 27.70461  5.72542   -8.67396  1.000 34.59641  ? 369 ILE A HG13 1 
ATOM   5529 H  HG21 . ILE A 1 377 ? 26.38381  6.70281   -10.40302 1.000 23.37975  ? 369 ILE A HG21 1 
ATOM   5530 H  HG22 . ILE A 1 377 ? 26.39198  6.13881   -11.88806 1.000 23.37975  ? 369 ILE A HG22 1 
ATOM   5531 H  HG23 . ILE A 1 377 ? 25.56636  5.38772   -10.75770 1.000 23.37975  ? 369 ILE A HG23 1 
ATOM   5532 H  HD11 . ILE A 1 377 ? 26.68131  4.03285   -7.53309  1.000 31.02902  ? 369 ILE A HD11 1 
ATOM   5533 H  HD12 . ILE A 1 377 ? 25.74191  4.42776   -8.75173  1.000 31.02902  ? 369 ILE A HD12 1 
ATOM   5534 H  HD13 . ILE A 1 377 ? 26.64759  3.12543   -8.83653  1.000 31.02902  ? 369 ILE A HD13 1 
ATOM   5535 N  N    . CYS A 1 378 ? 26.24821  3.69297   -13.38959 1.000 30.02302  ? 370 CYS A N    1 
ATOM   5536 C  CA   . CYS A 1 378 ? 26.02467  3.67480   -14.82732 1.000 28.13513  ? 370 CYS A CA   1 
ATOM   5537 C  C    . CYS A 1 378 ? 24.90461  4.63144   -15.20400 1.000 26.70333  ? 370 CYS A C    1 
ATOM   5538 O  O    . CYS A 1 378 ? 24.00883  4.91281   -14.40637 1.000 35.72587  ? 370 CYS A O    1 
ATOM   5539 C  CB   . CYS A 1 378 ? 25.65824  2.26535   -15.31651 1.000 21.51624  ? 370 CYS A CB   1 
ATOM   5540 S  SG   . CYS A 1 378 ? 26.88014  0.98810   -14.91376 1.000 44.32905  ? 370 CYS A SG   1 
ATOM   5541 H  H    . CYS A 1 378 ? 25.52953  3.58284   -12.93027 1.000 36.00443  ? 370 CYS A H    1 
ATOM   5542 H  HA   . CYS A 1 378 ? 26.83533  3.96797   -15.27205 1.000 33.73896  ? 370 CYS A HA   1 
ATOM   5543 H  HB2  . CYS A 1 378 ? 24.81751  2.00568   -14.90829 1.000 25.79630  ? 370 CYS A HB2  1 
ATOM   5544 H  HB3  . CYS A 1 378 ? 25.56532  2.28797   -16.28179 1.000 25.79630  ? 370 CYS A HB3  1 
ATOM   5545 H  HG   . CYS A 1 378 ? 27.90211  1.22792   -15.49518 1.000 53.17167  ? 370 CYS A HG   1 
ATOM   5546 N  N    . GLU A 1 379 ? 24.95141  5.10941   -16.44535 1.000 25.30900  ? 371 GLU A N    1 
ATOM   5547 C  CA   . GLU A 1 379 ? 23.91228  5.94906   -17.02523 1.000 34.68412  ? 371 GLU A CA   1 
ATOM   5548 C  C    . GLU A 1 379 ? 23.78340  5.55491   -18.48975 1.000 34.94141  ? 371 GLU A C    1 
ATOM   5549 O  O    . GLU A 1 379 ? 24.80374  5.35220   -19.16521 1.000 31.52615  ? 371 GLU A O    1 
ATOM   5550 C  CB   . GLU A 1 379 ? 24.23104  7.44312   -16.91615 1.000 31.10937  ? 371 GLU A CB   1 
ATOM   5551 C  CG   . GLU A 1 379 ? 24.23081  7.95875   -15.48609 1.000 38.74951  ? 371 GLU A CG   1 
ATOM   5552 C  CD   . GLU A 1 379 ? 22.84468  8.02467   -14.87751 1.000 28.90444  ? 371 GLU A CD   1 
ATOM   5553 O  OE1  . GLU A 1 379 ? 21.86614  8.01759   -15.64215 1.000 36.02168  ? 371 GLU A OE1  1 
ATOM   5554 O  OE2  . GLU A 1 379 ? 22.74075  8.10414   -13.63647 1.000 28.66524  ? 371 GLU A OE2  1 
ATOM   5555 H  H    . GLU A 1 379 ? 25.59943  4.95418   -16.98901 1.000 30.34761  ? 371 GLU A H    1 
ATOM   5556 H  HA   . GLU A 1 379 ? 23.07148  5.80247   -16.56428 1.000 41.59775  ? 371 GLU A HA   1 
ATOM   5557 H  HB2  . GLU A 1 379 ? 25.11163  7.60340   -17.29002 1.000 37.30806  ? 371 GLU A HB2  1 
ATOM   5558 H  HB3  . GLU A 1 379 ? 23.56393  7.94256   -17.41256 1.000 37.30806  ? 371 GLU A HB3  1 
ATOM   5559 H  HG2  . GLU A 1 379 ? 24.76945  7.36679   -14.93805 1.000 46.47622  ? 371 GLU A HG2  1 
ATOM   5560 H  HG3  . GLU A 1 379 ? 24.60478  8.85368   -15.47419 1.000 46.47622  ? 371 GLU A HG3  1 
ATOM   5561 N  N    . PRO A 1 380 ? 22.56361  5.42619   -19.00702 1.000 37.06233  ? 372 PRO A N    1 
ATOM   5562 C  CA   . PRO A 1 380 ? 22.40708  4.99546   -20.40347 1.000 43.24789  ? 372 PRO A CA   1 
ATOM   5563 C  C    . PRO A 1 380 ? 22.63905  6.15142   -21.36667 1.000 31.77329  ? 372 PRO A C    1 
ATOM   5564 O  O    . PRO A 1 380 ? 22.21430  7.28319   -21.12342 1.000 35.73604  ? 372 PRO A O    1 
ATOM   5565 C  CB   . PRO A 1 380 ? 20.95804  4.49478   -20.46040 1.000 28.14456  ? 372 PRO A CB   1 
ATOM   5566 C  CG   . PRO A 1 380 ? 20.24516  5.36422   -19.45559 1.000 27.17698  ? 372 PRO A CG   1 
ATOM   5567 C  CD   . PRO A 1 380 ? 21.26936  5.72614   -18.36537 1.000 28.65321  ? 372 PRO A CD   1 
ATOM   5568 H  HA   . PRO A 1 380 ? 23.00892  4.26534   -20.61705 1.000 51.87428  ? 372 PRO A HA   1 
ATOM   5569 H  HB2  . PRO A 1 380 ? 20.59524  4.61608   -21.35178 1.000 33.75029  ? 372 PRO A HB2  1 
ATOM   5570 H  HB3  . PRO A 1 380 ? 20.91571  3.55874   -20.20953 1.000 33.75029  ? 372 PRO A HB3  1 
ATOM   5571 H  HG2  . PRO A 1 380 ? 19.92064  6.16551   -19.89550 1.000 32.58918  ? 372 PRO A HG2  1 
ATOM   5572 H  HG3  . PRO A 1 380 ? 19.50220  4.87179   -19.07293 1.000 32.58918  ? 372 PRO A HG3  1 
ATOM   5573 H  HD2  . PRO A 1 380 ? 21.20863  6.66574   -18.13224 1.000 34.36066  ? 372 PRO A HD2  1 
ATOM   5574 H  HD3  . PRO A 1 380 ? 21.14049  5.17915   -17.57474 1.000 34.36066  ? 372 PRO A HD3  1 
ATOM   5575 N  N    . THR A 1 381 ? 23.34077  5.85473   -22.46486 1.000 34.71906  ? 373 THR A N    1 
ATOM   5576 C  CA   . THR A 1 381 ? 23.53559  6.85785   -23.50574 1.000 34.68712  ? 373 THR A CA   1 
ATOM   5577 C  C    . THR A 1 381 ? 22.26211  7.03611   -24.32404 1.000 43.19272  ? 373 THR A C    1 
ATOM   5578 O  O    . THR A 1 381 ? 21.90857  8.15738   -24.70334 1.000 56.34327  ? 373 THR A O    1 
ATOM   5579 C  CB   . THR A 1 381 ? 24.69967  6.45800   -24.41759 1.000 37.72830  ? 373 THR A CB   1 
ATOM   5580 O  OG1  . THR A 1 381 ? 24.34021  5.28937   -25.16517 1.000 46.92675  ? 373 THR A OG1  1 
ATOM   5581 C  CG2  . THR A 1 381 ? 25.94488  6.16306   -23.61806 1.000 36.45442  ? 373 THR A CG2  1 
ATOM   5582 H  H    . THR A 1 381 ? 23.70663  5.09331   -22.62604 1.000 41.63968  ? 373 THR A H    1 
ATOM   5583 H  HA   . THR A 1 381 ? 23.76055  7.70446   -23.08914 1.000 41.60135  ? 373 THR A HA   1 
ATOM   5584 H  HB   . THR A 1 381 ? 24.89456  7.19276   -25.02011 1.000 45.25078  ? 373 THR A HB   1 
ATOM   5585 H  HG1  . THR A 1 381 ? 24.90187  5.15443   -25.77503 1.000 56.28891  ? 373 THR A HG1  1 
ATOM   5586 H  HG21 . THR A 1 381 ? 26.67433  5.93072   -24.21373 1.000 43.72212  ? 373 THR A HG21 1 
ATOM   5587 H  HG22 . THR A 1 381 ? 26.19828  6.94240   -23.09911 1.000 43.72212  ? 373 THR A HG22 1 
ATOM   5588 H  HG23 . THR A 1 381 ? 25.78338  5.42151   -23.01397 1.000 43.72212  ? 373 THR A HG23 1 
ATOM   5589 N  N    . ARG A 1 382 ? 21.56708  5.94175   -24.60658 1.000 43.59654  ? 374 ARG A N    1 
ATOM   5590 C  CA   . ARG A 1 382 ? 20.31930  5.94128   -25.35199 1.000 42.76661  ? 374 ARG A CA   1 
ATOM   5591 C  C    . ARG A 1 382 ? 19.14179  5.95731   -24.38789 1.000 38.60509  ? 374 ARG A C    1 
ATOM   5592 O  O    . ARG A 1 382 ? 19.25273  5.54009   -23.23414 1.000 39.10840  ? 374 ARG A O    1 
ATOM   5593 C  CB   . ARG A 1 382 ? 20.24710  4.70786   -26.25074 1.000 47.18082  ? 374 ARG A CB   1 
ATOM   5594 C  CG   . ARG A 1 382 ? 19.13334  4.71543   -27.28087 1.000 59.41091  ? 374 ARG A CG   1 
ATOM   5595 C  CD   . ARG A 1 382 ? 19.19221  3.43102   -28.10515 1.000 57.81950  ? 374 ARG A CD   1 
ATOM   5596 N  NE   . ARG A 1 382 ? 17.86564  2.90198   -28.39967 1.000 51.60250  ? 374 ARG A NE   1 
ATOM   5597 C  CZ   . ARG A 1 382 ? 17.61011  1.62554   -28.66423 1.000 54.14934  ? 374 ARG A CZ   1 
ATOM   5598 N  NH1  . ARG A 1 382 ? 18.60162  0.73335   -28.67019 1.000 48.87344  ? 374 ARG A NH1  1 
ATOM   5599 N  NH2  . ARG A 1 382 ? 16.36089  1.24998   -28.93148 1.000 43.06130  ? 374 ARG A NH2  1 
ATOM   5600 H  H    . ARG A 1 382 ? 21.81026  5.15282   -24.36562 1.000 52.29265  ? 374 ARG A H    1 
ATOM   5601 H  HA   . ARG A 1 382 ? 20.26473  6.73040   -25.91342 1.000 51.29674  ? 374 ARG A HA   1 
ATOM   5602 H  HB2  . ARG A 1 382 ? 21.08557  4.63188   -26.73252 1.000 56.59379  ? 374 ARG A HB2  1 
ATOM   5603 H  HB3  . ARG A 1 382 ? 20.11550  3.92819   -25.68886 1.000 56.59379  ? 374 ARG A HB3  1 
ATOM   5604 H  HG2  . ARG A 1 382 ? 18.27321  4.76219   -26.83488 1.000 71.26991  ? 374 ARG A HG2  1 
ATOM   5605 H  HG3  . ARG A 1 382 ? 19.24046  5.47432   -27.87543 1.000 71.26991  ? 374 ARG A HG3  1 
ATOM   5606 H  HD2  . ARG A 1 382 ? 19.63811  3.61347   -28.94704 1.000 69.36022  ? 374 ARG A HD2  1 
ATOM   5607 H  HD3  . ARG A 1 382 ? 19.68268  2.75694   -27.60921 1.000 69.36022  ? 374 ARG A HD3  1 
ATOM   5608 H  HE   . ARG A 1 382 ? 17.20511  3.45270   -28.40227 1.000 61.89981  ? 374 ARG A HE   1 
ATOM   5609 H  HH11 . ARG A 1 382 ? 19.40695  0.98435   -28.50270 1.000 58.62494  ? 374 ARG A HH11 1 
ATOM   5610 H  HH12 . ARG A 1 382 ? 18.43558  -0.09289  -28.84154 1.000 58.62494  ? 374 ARG A HH12 1 
ATOM   5611 H  HH21 . ARG A 1 382 ? 15.72768  1.83191   -28.93182 1.000 51.65037  ? 374 ARG A HH21 1 
ATOM   5612 H  HH22 . ARG A 1 382 ? 16.18728  0.42549   -29.10374 1.000 51.65037  ? 374 ARG A HH22 1 
ATOM   5613 N  N    . LYS A 1 383 ? 18.00599  6.44785   -24.87235 1.000 37.07166  ? 375 LYS A N    1 
ATOM   5614 C  CA   . LYS A 1 383 ? 16.84917  6.61480   -24.00568 1.000 41.95102  ? 375 LYS A CA   1 
ATOM   5615 C  C    . LYS A 1 383 ? 16.20945  5.27001   -23.67753 1.000 39.28566  ? 375 LYS A C    1 
ATOM   5616 O  O    . LYS A 1 383 ? 16.20832  4.33603   -24.48430 1.000 37.80383  ? 375 LYS A O    1 
ATOM   5617 C  CB   . LYS A 1 383 ? 15.81389  7.53066   -24.65532 1.000 48.32612  ? 375 LYS A CB   1 
ATOM   5618 C  CG   . LYS A 1 383 ? 14.76328  8.05209   -23.67259 1.000 61.27695  ? 375 LYS A CG   1 
ATOM   5619 C  CD   . LYS A 1 383 ? 13.89755  9.15371   -24.28738 1.000 58.36377  ? 375 LYS A CD   1 
ATOM   5620 C  CE   . LYS A 1 383 ? 13.15996  8.65441   -25.52595 1.000 57.13670  ? 375 LYS A CE   1 
ATOM   5621 N  NZ   . LYS A 1 383 ? 12.44802  7.35558   -25.27824 1.000 45.91575  ? 375 LYS A NZ   1 
ATOM   5622 H  H    . LYS A 1 383 ? 17.88200  6.68813   -25.68874 1.000 44.46280  ? 375 LYS A H    1 
ATOM   5623 H  HA   . LYS A 1 383 ? 17.13867  7.02385   -23.17515 1.000 50.31803  ? 375 LYS A HA   1 
ATOM   5624 H  HB2  . LYS A 1 383 ? 16.26954  8.29657   -25.03828 1.000 57.96816  ? 375 LYS A HB2  1 
ATOM   5625 H  HB3  . LYS A 1 383 ? 15.35194  7.03739   -25.35116 1.000 57.96816  ? 375 LYS A HB3  1 
ATOM   5626 H  HG2  . LYS A 1 383 ? 14.18167  7.32159   -23.40988 1.000 73.50915  ? 375 LYS A HG2  1 
ATOM   5627 H  HG3  . LYS A 1 383 ? 15.20943  8.41784   -22.89279 1.000 73.50915  ? 375 LYS A HG3  1 
ATOM   5628 H  HD2  . LYS A 1 383 ? 13.23974  9.44651   -23.63742 1.000 70.01333  ? 375 LYS A HD2  1 
ATOM   5629 H  HD3  . LYS A 1 383 ? 14.46153  9.89885   -24.54737 1.000 70.01333  ? 375 LYS A HD3  1 
ATOM   5630 H  HE2  . LYS A 1 383 ? 12.50050  9.31438   -25.79137 1.000 68.54085  ? 375 LYS A HE2  1 
ATOM   5631 H  HE3  . LYS A 1 383 ? 13.79866  8.51669   -26.24288 1.000 68.54085  ? 375 LYS A HE3  1 
ATOM   5632 H  HZ1  . LYS A 1 383 ? 11.93012  7.15488   -25.97365 1.000 55.07571  ? 375 LYS A HZ1  1 
ATOM   5633 H  HZ2  . LYS A 1 383 ? 13.04006  6.70152   -25.16074 1.000 55.07571  ? 375 LYS A HZ2  1 
ATOM   5634 H  HZ3  . LYS A 1 383 ? 11.94096  7.42051   -24.54970 1.000 55.07571  ? 375 LYS A HZ3  1 
ATOM   5635 N  N    . ILE A 1 384 ? 15.65611  5.18411   -22.47329 1.000 31.85375  ? 376 ILE A N    1 
ATOM   5636 C  CA   . ILE A 1 384 ? 15.05560  3.96058   -21.95657 1.000 25.24334  ? 376 ILE A CA   1 
ATOM   5637 C  C    . ILE A 1 384 ? 13.53954  4.07504   -22.05708 1.000 27.04058  ? 376 ILE A C    1 
ATOM   5638 O  O    . ILE A 1 384 ? 12.96461  5.10974   -21.70082 1.000 25.57753  ? 376 ILE A O    1 
ATOM   5639 C  CB   . ILE A 1 384 ? 15.49500  3.71786   -20.50118 1.000 30.01977  ? 376 ILE A CB   1 
ATOM   5640 C  CG1  . ILE A 1 384 ? 17.01071  3.49330   -20.43154 1.000 37.85429  ? 376 ILE A CG1  1 
ATOM   5641 C  CG2  . ILE A 1 384 ? 14.73602  2.55689   -19.87849 1.000 29.82801  ? 376 ILE A CG2  1 
ATOM   5642 C  CD1  . ILE A 1 384 ? 17.49084  2.26335   -21.13878 1.000 28.84978  ? 376 ILE A CD1  1 
ATOM   5643 H  H    . ILE A 1 384 ? 15.61534  5.84165   -21.92049 1.000 38.20132  ? 376 ILE A H    1 
ATOM   5644 H  HA   . ILE A 1 384 ? 15.33454  3.20700   -22.49990 1.000 30.26881  ? 376 ILE A HA   1 
ATOM   5645 H  HB   . ILE A 1 384 ? 15.28038  4.51207   -19.98732 1.000 36.00053  ? 376 ILE A HB   1 
ATOM   5646 H  HG12 . ILE A 1 384 ? 17.45464  4.25528   -20.83554 1.000 45.40196  ? 376 ILE A HG12 1 
ATOM   5647 H  HG13 . ILE A 1 384 ? 17.26873  3.41465   -19.49980 1.000 45.40196  ? 376 ILE A HG13 1 
ATOM   5648 H  HG21 . ILE A 1 384 ? 15.09767  2.38025   -18.99593 1.000 35.77042  ? 376 ILE A HG21 1 
ATOM   5649 H  HG22 . ILE A 1 384 ? 13.79775  2.79330   -19.81026 1.000 35.77042  ? 376 ILE A HG22 1 
ATOM   5650 H  HG23 . ILE A 1 384 ? 14.83971  1.77367   -20.44128 1.000 35.77042  ? 376 ILE A HG23 1 
ATOM   5651 H  HD11 . ILE A 1 384 ? 18.44770  2.17589   -21.00591 1.000 34.59655  ? 376 ILE A HD11 1 
ATOM   5652 H  HD12 . ILE A 1 384 ? 17.03399  1.48993   -20.77269 1.000 34.59655  ? 376 ILE A HD12 1 
ATOM   5653 H  HD13 . ILE A 1 384 ? 17.29450  2.34626   -22.08508 1.000 34.59655  ? 376 ILE A HD13 1 
ATOM   5654 N  N    . ARG A 1 385 ? 12.88922  3.00789   -22.53087 1.000 21.36925  ? 377 ARG A N    1 
ATOM   5655 C  CA   . ARG A 1 385 ? 11.43855  2.86867   -22.44657 1.000 26.13537  ? 377 ARG A CA   1 
ATOM   5656 C  C    . ARG A 1 385 ? 11.12755  2.07531   -21.18095 1.000 23.77793  ? 377 ARG A C    1 
ATOM   5657 O  O    . ARG A 1 385 ? 11.16603  0.84320   -21.21495 1.000 19.34621  ? 377 ARG A O    1 
ATOM   5658 C  CB   . ARG A 1 385 ? 10.88148  2.16215   -23.68503 1.000 23.80717  ? 377 ARG A CB   1 
ATOM   5659 C  CG   . ARG A 1 385 ? 11.18343  2.88566   -24.98620 1.000 25.38882  ? 377 ARG A CG   1 
ATOM   5660 C  CD   . ARG A 1 385 ? 10.72437  2.05879   -26.20499 1.000 27.10965  ? 377 ARG A CD   1 
ATOM   5661 N  NE   . ARG A 1 385 ? 11.42005  0.77876   -26.26713 1.000 23.44086  ? 377 ARG A NE   1 
ATOM   5662 C  CZ   . ARG A 1 385 ? 12.68216  0.63089   -26.65693 1.000 26.99208  ? 377 ARG A CZ   1 
ATOM   5663 N  NH1  . ARG A 1 385 ? 13.38540  1.68763   -27.05274 1.000 34.05959  ? 377 ARG A NH1  1 
ATOM   5664 N  NH2  . ARG A 1 385 ? 13.24195  -0.57580  -26.64618 1.000 29.80472  ? 377 ARG A NH2  1 
ATOM   5665 H  H    . ARG A 1 385 ? 13.27543  2.34064   -22.91195 1.000 25.61991  ? 377 ARG A H    1 
ATOM   5666 H  HA   . ARG A 1 385 ? 11.01024  3.73793   -22.40378 1.000 31.33926  ? 377 ARG A HA   1 
ATOM   5667 H  HB2  . ARG A 1 385 ? 11.27167  1.27585   -23.74093 1.000 28.54541  ? 377 ARG A HB2  1 
ATOM   5668 H  HB3  . ARG A 1 385 ? 9.91757   2.09548   -23.59942 1.000 28.54541  ? 377 ARG A HB3  1 
ATOM   5669 H  HG2  . ARG A 1 385 ? 10.71517  3.73506   -24.99883 1.000 30.44340  ? 377 ARG A HG2  1 
ATOM   5670 H  HG3  . ARG A 1 385 ? 12.13946  3.03275   -25.05883 1.000 30.44340  ? 377 ARG A HG3  1 
ATOM   5671 H  HD2  . ARG A 1 385 ? 9.77214   1.88678   -26.13734 1.000 32.50839  ? 377 ARG A HD2  1 
ATOM   5672 H  HD3  . ARG A 1 385 ? 10.91559  2.55101   -27.01866 1.000 32.50839  ? 377 ARG A HD3  1 
ATOM   5673 H  HE   . ARG A 1 385 ? 10.98537  0.07345   -26.03650 1.000 28.10585  ? 377 ARG A HE   1 
ATOM   5674 H  HH11 . ARG A 1 385 ? 13.02372  2.46787   -27.05674 1.000 40.84832  ? 377 ARG A HH11 1 
ATOM   5675 H  HH12 . ARG A 1 385 ? 14.20193  1.59089   -27.30476 1.000 40.84832  ? 377 ARG A HH12 1 
ATOM   5676 H  HH21 . ARG A 1 385 ? 12.78736  -1.25841  -26.38736 1.000 35.74247  ? 377 ARG A HH21 1 
ATOM   5677 H  HH22 . ARG A 1 385 ? 14.05843  -0.67331  -26.89806 1.000 35.74247  ? 377 ARG A HH22 1 
ATOM   5678 N  N    . PRO A 1 386 ? 10.81291  2.72643   -20.05397 1.000 19.56034  ? 378 PRO A N    1 
ATOM   5679 C  CA   . PRO A 1 386 ? 10.84738  2.00824   -18.76276 1.000 27.36441  ? 378 PRO A CA   1 
ATOM   5680 C  C    . PRO A 1 386 ? 9.73392   0.99612   -18.58260 1.000 23.14853  ? 378 PRO A C    1 
ATOM   5681 O  O    . PRO A 1 386 ? 9.90130   0.07339   -17.77174 1.000 20.46076  ? 378 PRO A O    1 
ATOM   5682 C  CB   . PRO A 1 386 ? 10.75054  3.13087   -17.71518 1.000 21.60831  ? 378 PRO A CB   1 
ATOM   5683 C  CG   . PRO A 1 386 ? 10.13547  4.29460   -18.42498 1.000 27.94306  ? 378 PRO A CG   1 
ATOM   5684 C  CD   . PRO A 1 386 ? 10.35630  4.11655   -19.92540 1.000 19.98174  ? 378 PRO A CD   1 
ATOM   5685 H  HA   . PRO A 1 386 ? 11.70198  1.55863   -18.67100 1.000 32.81410  ? 378 PRO A HA   1 
ATOM   5686 H  HB2  . PRO A 1 386 ? 10.19103  2.84248   -16.97716 1.000 25.90678  ? 378 PRO A HB2  1 
ATOM   5687 H  HB3  . PRO A 1 386 ? 11.63736  3.35406   -17.39170 1.000 25.90678  ? 378 PRO A HB3  1 
ATOM   5688 H  HG2  . PRO A 1 386 ? 9.18606   4.31985   -18.22779 1.000 33.50848  ? 378 PRO A HG2  1 
ATOM   5689 H  HG3  . PRO A 1 386 ? 10.55958  5.11178   -18.11961 1.000 33.50848  ? 378 PRO A HG3  1 
ATOM   5690 H  HD2  . PRO A 1 386 ? 9.52815   4.25161   -20.41205 1.000 23.95490  ? 378 PRO A HD2  1 
ATOM   5691 H  HD3  . PRO A 1 386 ? 11.03426  4.73108   -20.24729 1.000 23.95490  ? 378 PRO A HD3  1 
ATOM   5692 N  N    . TRP A 1 387 ? 8.61956   1.12054   -19.30785 1.000 22.45367  ? 379 TRP A N    1 
ATOM   5693 C  CA   . TRP A 1 387 ? 7.46863   0.24606   -19.10820 1.000 21.42242  ? 379 TRP A CA   1 
ATOM   5694 C  C    . TRP A 1 387 ? 7.41360   -0.91108  -20.10085 1.000 21.55679  ? 379 TRP A C    1 
ATOM   5695 O  O    . TRP A 1 387 ? 6.37546   -1.57938  -20.21000 1.000 17.63356  ? 379 TRP A O    1 
ATOM   5696 C  CB   . TRP A 1 387 ? 6.17611   1.06032   -19.16793 1.000 22.59601  ? 379 TRP A CB   1 
ATOM   5697 C  CG   . TRP A 1 387 ? 6.17801   2.20594   -18.20545 1.000 20.83309  ? 379 TRP A CG   1 
ATOM   5698 C  CD1  . TRP A 1 387 ? 6.44524   3.50496   -18.49234 1.000 26.82368  ? 379 TRP A CD1  1 
ATOM   5699 C  CD2  . TRP A 1 387 ? 5.91789   2.15200   -16.79907 1.000 23.13579  ? 379 TRP A CD2  1 
ATOM   5700 N  NE1  . TRP A 1 387 ? 6.36639   4.26778   -17.36027 1.000 25.53754  ? 379 TRP A NE1  1 
ATOM   5701 C  CE2  . TRP A 1 387 ? 6.04186   3.46046   -16.30462 1.000 22.48492  ? 379 TRP A CE2  1 
ATOM   5702 C  CE3  . TRP A 1 387 ? 5.59547   1.12450   -15.91179 1.000 23.49127  ? 379 TRP A CE3  1 
ATOM   5703 C  CZ2  . TRP A 1 387 ? 5.84464   3.77088   -14.96891 1.000 23.20707  ? 379 TRP A CZ2  1 
ATOM   5704 C  CZ3  . TRP A 1 387 ? 5.40243   1.43133   -14.59193 1.000 23.24109  ? 379 TRP A CZ3  1 
ATOM   5705 C  CH2  . TRP A 1 387 ? 5.53036   2.74228   -14.12731 1.000 29.73295  ? 379 TRP A CH2  1 
ATOM   5706 H  H    . TRP A 1 387 ? 8.50868   1.70911   -19.92501 1.000 26.92121  ? 379 TRP A H    1 
ATOM   5707 H  HA   . TRP A 1 387 ? 7.53396   -0.14389  -18.22244 1.000 25.68372  ? 379 TRP A HA   1 
ATOM   5708 H  HB2  . TRP A 1 387 ? 6.06809   1.41847   -20.06290 1.000 27.09202  ? 379 TRP A HB2  1 
ATOM   5709 H  HB3  . TRP A 1 387 ? 5.42763   0.48355   -18.94883 1.000 27.09202  ? 379 TRP A HB3  1 
ATOM   5710 H  HD1  . TRP A 1 387 ? 6.65255   3.83022   -19.33859 1.000 32.16522  ? 379 TRP A HD1  1 
ATOM   5711 H  HE1  . TRP A 1 387 ? 6.49913   5.11646   -17.31868 1.000 30.62186  ? 379 TRP A HE1  1 
ATOM   5712 H  HE3  . TRP A 1 387 ? 5.51331   0.24795   -16.21148 1.000 28.16634  ? 379 TRP A HE3  1 
ATOM   5713 H  HZ2  . TRP A 1 387 ? 5.92305   4.64390   -14.65814 1.000 27.82529  ? 379 TRP A HZ2  1 
ATOM   5714 H  HZ3  . TRP A 1 387 ? 5.18202   0.75445   -13.99348 1.000 27.86612  ? 379 TRP A HZ3  1 
ATOM   5715 H  HH2  . TRP A 1 387 ? 5.39846   2.91882   -13.22379 1.000 35.65636  ? 379 TRP A HH2  1 
ATOM   5716 N  N    . GLU A 1 388 ? 8.51236   -1.18277  -20.79755 1.000 27.12641  ? 380 GLU A N    1 
ATOM   5717 C  CA   . GLU A 1 388 ? 8.57956   -2.29602  -21.72783 1.000 18.34338  ? 380 GLU A CA   1 
ATOM   5718 C  C    . GLU A 1 388 ? 10.02504  -2.76205  -21.80554 1.000 21.39659  ? 380 GLU A C    1 
ATOM   5719 O  O    . GLU A 1 388 ? 10.91833  -2.17938  -21.18943 1.000 20.66542  ? 380 GLU A O    1 
ATOM   5720 C  CB   . GLU A 1 388 ? 8.04020   -1.89776  -23.10369 1.000 24.84129  ? 380 GLU A CB   1 
ATOM   5721 C  CG   . GLU A 1 388 ? 8.84725   -0.83819  -23.82282 1.000 23.56538  ? 380 GLU A CG   1 
ATOM   5722 C  CD   . GLU A 1 388 ? 8.21497   -0.42376  -25.15232 1.000 28.32201  ? 380 GLU A CD   1 
ATOM   5723 O  OE1  . GLU A 1 388 ? 7.16690   0.26188   -25.12763 1.000 27.52483  ? 380 GLU A OE1  1 
ATOM   5724 O  OE2  . GLU A 1 388 ? 8.76749   -0.78816  -26.21576 1.000 27.07018  ? 380 GLU A OE2  1 
ATOM   5725 H  H    . GLU A 1 388 ? 9.24083   -0.72859  -20.74601 1.000 32.52850  ? 380 GLU A H    1 
ATOM   5726 H  HA   . GLU A 1 388 ? 8.03715   -3.02685  -21.39231 1.000 21.98886  ? 380 GLU A HA   1 
ATOM   5727 H  HB2  . GLU A 1 388 ? 8.02631   -2.68635  -23.66834 1.000 29.78636  ? 380 GLU A HB2  1 
ATOM   5728 H  HB3  . GLU A 1 388 ? 7.14028   -1.55311  -22.99297 1.000 29.78636  ? 380 GLU A HB3  1 
ATOM   5729 H  HG2  . GLU A 1 388 ? 8.90914   -0.05040  -23.26027 1.000 28.25527  ? 380 GLU A HG2  1 
ATOM   5730 H  HG3  . GLU A 1 388 ? 9.73423   -1.18526  -24.00642 1.000 28.25527  ? 380 GLU A HG3  1 
ATOM   5731 N  N    . ALA A 1 389 ? 10.25695  -3.81452  -22.57964 1.000 18.57570  ? 381 ALA A N    1 
ATOM   5732 C  CA   . ALA A 1 389 ? 11.60392  -4.35049  -22.71528 1.000 22.47829  ? 381 ALA A CA   1 
ATOM   5733 C  C    . ALA A 1 389 ? 12.51874  -3.40212  -23.49137 1.000 26.14445  ? 381 ALA A C    1 
ATOM   5734 O  O    . ALA A 1 389 ? 12.09070  -2.67749  -24.39505 1.000 17.32772  ? 381 ALA A O    1 
ATOM   5735 C  CB   . ALA A 1 389 ? 11.56448  -5.70616  -23.41550 1.000 27.46726  ? 381 ALA A CB   1 
ATOM   5736 H  H    . ALA A 1 389 ? 9.65752   -4.23276  -23.03279 1.000 22.26766  ? 381 ALA A H    1 
ATOM   5737 H  HA   . ALA A 1 389 ? 11.98153  -4.46347  -21.82897 1.000 26.95076  ? 381 ALA A HA   1 
ATOM   5738 H  HB1  . ALA A 1 389 ? 12.47112  -6.03578  -23.51680 1.000 32.93752  ? 381 ALA A HB1  1 
ATOM   5739 H  HB2  . ALA A 1 389 ? 11.04588  -6.32456  -22.87741 1.000 32.93752  ? 381 ALA A HB2  1 
ATOM   5740 H  HB3  . ALA A 1 389 ? 11.15195  -5.59962  -24.28692 1.000 32.93752  ? 381 ALA A HB3  1 
ATOM   5741 N  N    . ASN A 1 390 ? 13.79407  -3.39922  -23.10451 1.000 21.20292  ? 382 ASN A N    1 
ATOM   5742 C  CA   . ASN A 1 390 ? 14.83681  -2.65442  -23.79125 1.000 22.10991  ? 382 ASN A CA   1 
ATOM   5743 C  C    . ASN A 1 390 ? 15.99143  -3.60394  -24.06967 1.000 25.53544  ? 382 ASN A C    1 
ATOM   5744 O  O    . ASN A 1 390 ? 16.20395  -4.57071  -23.33361 1.000 20.75992  ? 382 ASN A O    1 
ATOM   5745 C  CB   . ASN A 1 390 ? 15.32611  -1.46045  -22.96233 1.000 20.33128  ? 382 ASN A CB   1 
ATOM   5746 C  CG   . ASN A 1 390 ? 14.24901  -0.39898  -22.77108 1.000 24.90335  ? 382 ASN A CG   1 
ATOM   5747 O  OD1  . ASN A 1 390 ? 14.21132  0.60944   -23.49346 1.000 24.42295  ? 382 ASN A OD1  1 
ATOM   5748 N  ND2  . ASN A 1 390 ? 13.36630  -0.62012  -21.79528 1.000 18.36587  ? 382 ASN A ND2  1 
ATOM   5749 H  H    . ASN A 1 390 ? 14.08512  -3.83699  -22.42389 1.000 25.42031  ? 382 ASN A H    1 
ATOM   5750 H  HA   . ASN A 1 390 ? 14.50236  -2.30402  -24.63165 1.000 26.50870  ? 382 ASN A HA   1 
ATOM   5751 H  HB2  . ASN A 1 390 ? 15.59822  -1.77389  -22.08563 1.000 24.37435  ? 382 ASN A HB2  1 
ATOM   5752 H  HB3  . ASN A 1 390 ? 16.07800  -1.04750  -23.41513 1.000 24.37435  ? 382 ASN A HB3  1 
ATOM   5753 H  HD21 . ASN A 1 390 ? 12.73856  -0.05148  -21.64629 1.000 22.01586  ? 382 ASN A HD21 1 
ATOM   5754 H  HD22 . ASN A 1 390 ? 13.42508  -1.33130  -21.31531 1.000 22.01586  ? 382 ASN A HD22 1 
ATOM   5755 N  N    . THR A 1 391 ? 16.73751  -3.31739  -25.13429 1.000 20.31969  ? 383 THR A N    1 
ATOM   5756 C  CA   . THR A 1 391 ? 17.92792  -4.08125  -25.49393 1.000 21.53808  ? 383 THR A CA   1 
ATOM   5757 C  C    . THR A 1 391 ? 19.04389  -3.08677  -25.77743 1.000 37.01841  ? 383 THR A C    1 
ATOM   5758 O  O    . THR A 1 391 ? 19.03508  -2.42120  -26.81840 1.000 29.19145  ? 383 THR A O    1 
ATOM   5759 C  CB   . THR A 1 391 ? 17.67661  -4.97330  -26.70636 1.000 23.23779  ? 383 THR A CB   1 
ATOM   5760 O  OG1  . THR A 1 391 ? 16.73907  -5.99605  -26.35792 1.000 37.02829  ? 383 THR A OG1  1 
ATOM   5761 C  CG2  . THR A 1 391 ? 18.97792  -5.61160  -27.15418 1.000 37.70651  ? 383 THR A CG2  1 
ATOM   5762 H  H    . THR A 1 391 ? 16.56963  -2.67017  -25.67515 1.000 24.36044  ? 383 THR A H    1 
ATOM   5763 H  HA   . THR A 1 391 ? 18.18736  -4.64915  -24.75159 1.000 25.82251  ? 383 THR A HA   1 
ATOM   5764 H  HB   . THR A 1 391 ? 17.31918  -4.44741  -27.43888 1.000 27.86216  ? 383 THR A HB   1 
ATOM   5765 H  HG1  . THR A 1 391 ? 16.62016  -6.51126  -27.01062 1.000 44.41076  ? 383 THR A HG1  1 
ATOM   5766 H  HG21 . THR A 1 391 ? 18.81545  -6.20539  -27.90379 1.000 45.22463  ? 383 THR A HG21 1 
ATOM   5767 H  HG22 . THR A 1 391 ? 19.60738  -4.92569  -27.42659 1.000 45.22463  ? 383 THR A HG22 1 
ATOM   5768 H  HG23 . THR A 1 391 ? 19.36468  -6.12249  -26.42596 1.000 45.22463  ? 383 THR A HG23 1 
ATOM   5769 N  N    . LEU A 1 392 ? 19.99299  -2.97476  -24.85463 1.000 23.47189  ? 384 LEU A N    1 
ATOM   5770 C  CA   . LEU A 1 392 ? 21.09144  -2.03266  -24.98245 1.000 29.63211  ? 384 LEU A CA   1 
ATOM   5771 C  C    . LEU A 1 392 ? 22.38032  -2.76143  -25.33667 1.000 36.06720  ? 384 LEU A C    1 
ATOM   5772 O  O    . LEU A 1 392 ? 22.59568  -3.91575  -24.95041 1.000 30.56919  ? 384 LEU A O    1 
ATOM   5773 C  CB   . LEU A 1 392 ? 21.29206  -1.23628  -23.69214 1.000 30.60151  ? 384 LEU A CB   1 
ATOM   5774 C  CG   . LEU A 1 392 ? 20.53400  0.08558   -23.59457 1.000 32.22860  ? 384 LEU A CG   1 
ATOM   5775 C  CD1  . LEU A 1 392 ? 19.05373  -0.13394  -23.79568 1.000 35.90327  ? 384 LEU A CD1  1 
ATOM   5776 C  CD2  . LEU A 1 392 ? 20.79917  0.74339   -22.23375 1.000 36.10788  ? 384 LEU A CD2  1 
ATOM   5777 H  H    . LEU A 1 392 ? 20.02000  -3.44333  -24.13399 1.000 28.14308  ? 384 LEU A H    1 
ATOM   5778 H  HA   . LEU A 1 392 ? 20.88994  -1.40911  -25.69763 1.000 35.53534  ? 384 LEU A HA   1 
ATOM   5779 H  HB2  . LEU A 1 392 ? 21.00330  -1.78814  -22.94853 1.000 36.69862  ? 384 LEU A HB2  1 
ATOM   5780 H  HB3  . LEU A 1 392 ? 22.23653  -1.03231  -23.60678 1.000 36.69862  ? 384 LEU A HB3  1 
ATOM   5781 H  HG   . LEU A 1 392 ? 20.84383  0.68415   -24.29215 1.000 38.65113  ? 384 LEU A HG   1 
ATOM   5782 H  HD11 . LEU A 1 392 ? 18.58961  0.70850   -23.67009 1.000 43.06074  ? 384 LEU A HD11 1 
ATOM   5783 H  HD12 . LEU A 1 392 ? 18.90276  -0.46387  -24.69527 1.000 43.06074  ? 384 LEU A HD12 1 
ATOM   5784 H  HD13 . LEU A 1 392 ? 18.74003  -0.78420  -23.14788 1.000 43.06074  ? 384 LEU A HD13 1 
ATOM   5785 H  HD21 . LEU A 1 392 ? 20.28459  1.56346   -22.17377 1.000 43.30627  ? 384 LEU A HD21 1 
ATOM   5786 H  HD22 . LEU A 1 392 ? 20.53080  0.13225   -21.52992 1.000 43.30627  ? 384 LEU A HD22 1 
ATOM   5787 H  HD23 . LEU A 1 392 ? 21.74584  0.94059   -22.15743 1.000 43.30627  ? 384 LEU A HD23 1 
ATOM   5788 N  N    . ASP A 1 393 ? 23.22781  -2.06315  -26.08602 1.000 44.44399  ? 385 ASP A N    1 
ATOM   5789 C  CA   . ASP A 1 393 ? 24.56485  -2.52719  -26.40480 1.000 44.82847  ? 385 ASP A CA   1 
ATOM   5790 C  C    . ASP A 1 393 ? 25.50062  -2.27079  -25.22712 1.000 36.90565  ? 385 ASP A C    1 
ATOM   5791 O  O    . ASP A 1 393 ? 25.22677  -1.45127  -24.34821 1.000 33.77286  ? 385 ASP A O    1 
ATOM   5792 C  CB   . ASP A 1 393 ? 25.08256  -1.81919  -27.65949 1.000 45.93401  ? 385 ASP A CB   1 
ATOM   5793 C  CG   . ASP A 1 393 ? 26.16577  -2.59988  -28.36230 1.000 54.30649  ? 385 ASP A CG   1 
ATOM   5794 O  OD1  . ASP A 1 393 ? 27.35129  -2.22702  -28.20537 1.000 54.19198  ? 385 ASP A OD1  1 
ATOM   5795 O  OD2  . ASP A 1 393 ? 25.82372  -3.57674  -29.06919 1.000 56.98683  ? 385 ASP A OD2  1 
ATOM   5796 H  H    . ASP A 1 393 ? 23.04398  -1.29657  -26.42976 1.000 53.30960  ? 385 ASP A H    1 
ATOM   5797 H  HA   . ASP A 1 393 ? 24.55368  -3.48087  -26.58164 1.000 53.77098  ? 385 ASP A HA   1 
ATOM   5798 H  HB2  . ASP A 1 393 ? 24.34762  -1.69890  -28.28101 1.000 55.09763  ? 385 ASP A HB2  1 
ATOM   5799 H  HB3  . ASP A 1 393 ? 25.44883  -0.95694  -27.40795 1.000 55.09763  ? 385 ASP A HB3  1 
ATOM   5800 N  N    . VAL A 1 394 ? 26.61819  -2.99624  -25.20791 1.000 43.59434  ? 386 VAL A N    1 
ATOM   5801 C  CA   . VAL A 1 394 ? 27.68670  -2.65528  -24.27245 1.000 40.90223  ? 386 VAL A CA   1 
ATOM   5802 C  C    . VAL A 1 394 ? 28.05875  -1.18254  -24.41490 1.000 40.19007  ? 386 VAL A C    1 
ATOM   5803 O  O    . VAL A 1 394 ? 28.31243  -0.48503  -23.42308 1.000 30.98280  ? 386 VAL A O    1 
ATOM   5804 C  CB   . VAL A 1 394 ? 28.90270  -3.57231  -24.50249 1.000 50.18351  ? 386 VAL A CB   1 
ATOM   5805 C  CG1  . VAL A 1 394 ? 30.09722  -3.07370  -23.69878 1.000 61.56630  ? 386 VAL A CG1  1 
ATOM   5806 C  CG2  . VAL A 1 394 ? 28.55289  -5.00569  -24.14511 1.000 45.29115  ? 386 VAL A CG2  1 
ATOM   5807 H  H    . VAL A 1 394 ? 26.77849  -3.67342  -25.71321 1.000 52.29002  ? 386 VAL A H    1 
ATOM   5808 H  HA   . VAL A 1 394 ? 27.37034  -2.79929  -23.36687 1.000 49.05948  ? 386 VAL A HA   1 
ATOM   5809 H  HB   . VAL A 1 394 ? 29.15041  -3.55433  -25.44015 1.000 60.19703  ? 386 VAL A HB   1 
ATOM   5810 H  HG11 . VAL A 1 394 ? 30.82960  -3.70177  -23.79896 1.000 73.85637  ? 386 VAL A HG11 1 
ATOM   5811 H  HG12 . VAL A 1 394 ? 30.36093  -2.20205  -24.03282 1.000 73.85637  ? 386 VAL A HG12 1 
ATOM   5812 H  HG13 . VAL A 1 394 ? 29.84388  -3.00723  -22.76481 1.000 73.85637  ? 386 VAL A HG13 1 
ATOM   5813 H  HG21 . VAL A 1 394 ? 29.31819  -5.57270  -24.32873 1.000 54.32619  ? 386 VAL A HG21 1 
ATOM   5814 H  HG22 . VAL A 1 394 ? 28.32684  -5.05006  -23.20286 1.000 54.32619  ? 386 VAL A HG22 1 
ATOM   5815 H  HG23 . VAL A 1 394 ? 27.79535  -5.28882  -24.68071 1.000 54.32619  ? 386 VAL A HG23 1 
ATOM   5816 N  N    . ASP A 1 395 ? 28.07699  -0.68476  -25.65400 1.000 36.42687  ? 387 ASP A N    1 
ATOM   5817 C  CA   . ASP A 1 395 ? 28.49186  0.68164   -25.94330 1.000 39.77336  ? 387 ASP A CA   1 
ATOM   5818 C  C    . ASP A 1 395 ? 27.46205  1.71587   -25.52957 1.000 37.71953  ? 387 ASP A C    1 
ATOM   5819 O  O    . ASP A 1 395 ? 27.75168  2.91259   -25.61615 1.000 35.98688  ? 387 ASP A O    1 
ATOM   5820 C  CB   . ASP A 1 395 ? 28.77893  0.83079   -27.43811 1.000 44.26005  ? 387 ASP A CB   1 
ATOM   5821 C  CG   . ASP A 1 395 ? 29.91317  -0.06531  -27.89970 1.000 60.94879  ? 387 ASP A CG   1 
ATOM   5822 O  OD1  . ASP A 1 395 ? 30.91569  -0.14996  -27.15767 1.000 52.43988  ? 387 ASP A OD1  1 
ATOM   5823 O  OD2  . ASP A 1 395 ? 29.80520  -0.69128  -28.98084 1.000 60.57833  ? 387 ASP A OD2  1 
ATOM   5824 H  H    . ASP A 1 395 ? 27.84908  -1.12870  -26.35441 1.000 43.68905  ? 387 ASP A H    1 
ATOM   5825 H  HA   . ASP A 1 395 ? 29.30863  0.86179   -25.45206 1.000 47.70484  ? 387 ASP A HA   1 
ATOM   5826 H  HB2  . ASP A 1 395 ? 27.98341  0.59314   -27.93968 1.000 53.08887  ? 387 ASP A HB2  1 
ATOM   5827 H  HB3  . ASP A 1 395 ? 29.02600  1.75020   -27.62400 1.000 53.08887  ? 387 ASP A HB3  1 
ATOM   5828 N  N    . ASP A 1 396 ? 26.27874  1.29614   -25.09498 1.000 34.35557  ? 388 ASP A N    1 
ATOM   5829 C  CA   . ASP A 1 396 ? 25.24766  2.22388   -24.65241 1.000 35.45092  ? 388 ASP A CA   1 
ATOM   5830 C  C    . ASP A 1 396 ? 25.35696  2.55589   -23.16492 1.000 30.15175  ? 388 ASP A C    1 
ATOM   5831 O  O    . ASP A 1 396 ? 24.49716  3.26603   -22.62753 1.000 28.42496  ? 388 ASP A O    1 
ATOM   5832 C  CB   . ASP A 1 396 ? 23.86636  1.64728   -24.96745 1.000 41.95750  ? 388 ASP A CB   1 
ATOM   5833 C  CG   . ASP A 1 396 ? 23.62375  1.49709   -26.46204 1.000 44.42890  ? 388 ASP A CG   1 
ATOM   5834 O  OD1  . ASP A 1 396 ? 24.01413  2.40879   -27.22282 1.000 35.11862  ? 388 ASP A OD1  1 
ATOM   5835 O  OD2  . ASP A 1 396 ? 23.04690  0.46734   -26.87499 1.000 41.59656  ? 388 ASP A OD2  1 
ATOM   5836 H  H    . ASP A 1 396 ? 26.04808  0.46904   -25.04709 1.000 41.20350  ? 388 ASP A H    1 
ATOM   5837 H  HA   . ASP A 1 396 ? 25.33970  3.05588   -25.14252 1.000 42.51791  ? 388 ASP A HA   1 
ATOM   5838 H  HB2  . ASP A 1 396 ? 23.78875  0.77021   -24.56048 1.000 50.32581  ? 388 ASP A HB2  1 
ATOM   5839 H  HB3  . ASP A 1 396 ? 23.18659  2.24002   -24.61043 1.000 50.32581  ? 388 ASP A HB3  1 
ATOM   5840 N  N    . ILE A 1 397 ? 26.40141  2.07454   -22.49840 1.000 31.92504  ? 389 ILE A N    1 
ATOM   5841 C  CA   . ILE A 1 397 ? 26.60148  2.27080   -21.06783 1.000 32.22539  ? 389 ILE A CA   1 
ATOM   5842 C  C    . ILE A 1 397 ? 27.73268  3.26881   -20.87271 1.000 33.30829  ? 389 ILE A C    1 
ATOM   5843 O  O    . ILE A 1 397 ? 28.83824  3.07101   -21.38949 1.000 40.63981  ? 389 ILE A O    1 
ATOM   5844 C  CB   . ILE A 1 397 ? 26.92246  0.94264   -20.36026 1.000 31.60641  ? 389 ILE A CB   1 
ATOM   5845 C  CG1  . ILE A 1 397 ? 25.88259  -0.12815  -20.72089 1.000 33.67401  ? 389 ILE A CG1  1 
ATOM   5846 C  CG2  . ILE A 1 397 ? 27.00279  1.15677   -18.85646 1.000 33.82157  ? 389 ILE A CG2  1 
ATOM   5847 C  CD1  . ILE A 1 397 ? 24.46458  0.22454   -20.32527 1.000 28.30790  ? 389 ILE A CD1  1 
ATOM   5848 H  H    . ILE A 1 397 ? 27.02833  1.61544   -22.86691 1.000 38.28686  ? 389 ILE A H    1 
ATOM   5849 H  HA   . ILE A 1 397 ? 25.79320  2.64196   -20.68077 1.000 38.64728  ? 389 ILE A HA   1 
ATOM   5850 H  HB   . ILE A 1 397 ? 27.78639  0.62643   -20.66772 1.000 37.90450  ? 389 ILE A HB   1 
ATOM   5851 H  HG12 . ILE A 1 397 ? 25.89527  -0.26149  -21.68160 1.000 40.38563  ? 389 ILE A HG12 1 
ATOM   5852 H  HG13 . ILE A 1 397 ? 26.11750  -0.95330  -20.26830 1.000 40.38563  ? 389 ILE A HG13 1 
ATOM   5853 H  HG21 . ILE A 1 397 ? 27.13593  0.29973   -18.42210 1.000 40.56269  ? 389 ILE A HG21 1 
ATOM   5854 H  HG22 . ILE A 1 397 ? 27.74797  1.74610   -18.66074 1.000 40.56269  ? 389 ILE A HG22 1 
ATOM   5855 H  HG23 . ILE A 1 397 ? 26.17450  1.55784   -18.54989 1.000 40.56269  ? 389 ILE A HG23 1 
ATOM   5856 H  HD11 . ILE A 1 397 ? 23.87691  -0.50698  -20.57109 1.000 33.94629  ? 389 ILE A HD11 1 
ATOM   5857 H  HD12 . ILE A 1 397 ? 24.43065  0.36825   -19.36657 1.000 33.94629  ? 389 ILE A HD12 1 
ATOM   5858 H  HD13 . ILE A 1 397 ? 24.19872  1.03308   -20.79055 1.000 33.94629  ? 389 ILE A HD13 1 
ATOM   5859 N  N    . ASN A 1 398 ? 27.45859  4.34004   -20.13907 1.000 33.44735  ? 390 ASN A N    1 
ATOM   5860 C  CA   . ASN A 1 398 ? 28.48164  5.29027   -19.72101 1.000 35.93597  ? 390 ASN A CA   1 
ATOM   5861 C  C    . ASN A 1 398 ? 28.77191  5.06301   -18.24086 1.000 33.14928  ? 390 ASN A C    1 
ATOM   5862 O  O    . ASN A 1 398 ? 27.94449  5.39452   -17.38498 1.000 39.16586  ? 390 ASN A O    1 
ATOM   5863 C  CB   . ASN A 1 398 ? 28.02950  6.72477   -19.97488 1.000 37.22338  ? 390 ASN A CB   1 
ATOM   5864 C  CG   . ASN A 1 398 ? 29.10863  7.74405   -19.63794 1.000 42.94102  ? 390 ASN A CG   1 
ATOM   5865 O  OD1  . ASN A 1 398 ? 30.23317  7.38738   -19.28557 1.000 47.32999  ? 390 ASN A OD1  1 
ATOM   5866 N  ND2  . ASN A 1 398 ? 28.76972  9.01731   -19.74334 1.000 47.51592  ? 390 ASN A ND2  1 
ATOM   5867 H  H    . ASN A 1 398 ? 26.66897  4.54234   -19.86490 1.000 40.11363  ? 390 ASN A H    1 
ATOM   5868 H  HA   . ASN A 1 398 ? 29.29490  5.12953   -20.22466 1.000 43.09998  ? 390 ASN A HA   1 
ATOM   5869 H  HB2  . ASN A 1 398 ? 27.80344  6.82466   -20.91286 1.000 44.64487  ? 390 ASN A HB2  1 
ATOM   5870 H  HB3  . ASN A 1 398 ? 27.25364  6.91477   -19.42457 1.000 44.64487  ? 390 ASN A HB3  1 
ATOM   5871 H  HD21 . ASN A 1 398 ? 29.34433  9.63150   -19.56391 1.000 56.99592  ? 390 ASN A HD21 1 
ATOM   5872 H  HD22 . ASN A 1 398 ? 27.97461  9.23153   -19.99134 1.000 56.99592  ? 390 ASN A HD22 1 
ATOM   5873 N  N    . TYR A 1 399 ? 29.94256  4.49818   -17.94459 1.000 27.97301  ? 391 TYR A N    1 
ATOM   5874 C  CA   . TYR A 1 399 ? 30.39734  4.27157   -16.57089 1.000 28.78371  ? 391 TYR A CA   1 
ATOM   5875 C  C    . TYR A 1 399 ? 30.94085  5.58625   -16.01952 1.000 37.87961  ? 391 TYR A C    1 
ATOM   5876 O  O    . TYR A 1 399 ? 32.05952  5.99374   -16.33823 1.000 46.67012  ? 391 TYR A O    1 
ATOM   5877 C  CB   . TYR A 1 399 ? 31.44770  3.16400   -16.54722 1.000 31.78355  ? 391 TYR A CB   1 
ATOM   5878 C  CG   . TYR A 1 399 ? 30.92577  1.85825   -17.11078 1.000 37.81874  ? 391 TYR A CG   1 
ATOM   5879 C  CD1  . TYR A 1 399 ? 30.32922  0.91171   -16.28716 1.000 35.84568  ? 391 TYR A CD1  1 
ATOM   5880 C  CD2  . TYR A 1 399 ? 31.02568  1.57407   -18.46820 1.000 31.31593  ? 391 TYR A CD2  1 
ATOM   5881 C  CE1  . TYR A 1 399 ? 29.83747  -0.28228  -16.80083 1.000 37.82167  ? 391 TYR A CE1  1 
ATOM   5882 C  CE2  . TYR A 1 399 ? 30.54216  0.38714   -18.98953 1.000 34.89680  ? 391 TYR A CE2  1 
ATOM   5883 C  CZ   . TYR A 1 399 ? 29.94132  -0.53561  -18.15561 1.000 36.78647  ? 391 TYR A CZ   1 
ATOM   5884 O  OH   . TYR A 1 399 ? 29.45109  -1.71582  -18.67720 1.000 34.33310  ? 391 TYR A OH   1 
ATOM   5885 H  H    . TYR A 1 399 ? 30.50628  4.23039   -18.53629 1.000 33.54442  ? 391 TYR A H    1 
ATOM   5886 H  HA   . TYR A 1 399 ? 29.65239  3.99991   -16.01219 1.000 34.51726  ? 391 TYR A HA   1 
ATOM   5887 H  HB2  . TYR A 1 399 ? 32.21009  3.43904   -17.08016 1.000 38.11708  ? 391 TYR A HB2  1 
ATOM   5888 H  HB3  . TYR A 1 399 ? 31.72289  3.00799   -15.63025 1.000 38.11708  ? 391 TYR A HB3  1 
ATOM   5889 H  HD1  . TYR A 1 399 ? 30.25765  1.08022   -15.37535 1.000 42.99163  ? 391 TYR A HD1  1 
ATOM   5890 H  HD2  . TYR A 1 399 ? 31.42478  2.19308   -19.03605 1.000 37.55592  ? 391 TYR A HD2  1 
ATOM   5891 H  HE1  . TYR A 1 399 ? 29.44120  -0.90661  -16.23684 1.000 45.36281  ? 391 TYR A HE1  1 
ATOM   5892 H  HE2  . TYR A 1 399 ? 30.62151  0.21104   -19.89925 1.000 41.85297  ? 391 TYR A HE2  1 
ATOM   5893 H  HH   . TYR A 1 399 ? 29.11958  -2.18498  -18.06435 1.000 41.17653  ? 391 TYR A HH   1 
ATOM   5894 N  N    . VAL A 1 400 ? 30.14866  6.25646   -15.17993 1.000 40.12909  ? 392 VAL A N    1 
ATOM   5895 C  CA   . VAL A 1 400 ? 30.42969  7.64036   -14.80736 1.000 39.19603  ? 392 VAL A CA   1 
ATOM   5896 C  C    . VAL A 1 400 ? 31.16188  7.78208   -13.47715 1.000 39.41111  ? 392 VAL A C    1 
ATOM   5897 O  O    . VAL A 1 400 ? 31.70273  8.86371   -13.19342 1.000 43.71226  ? 392 VAL A O    1 
ATOM   5898 C  CB   . VAL A 1 400 ? 29.12641  8.46467   -14.76293 1.000 35.19807  ? 392 VAL A CB   1 
ATOM   5899 C  CG1  . VAL A 1 400 ? 28.45805  8.49203   -16.12478 1.000 37.11929  ? 392 VAL A CG1  1 
ATOM   5900 C  CG2  . VAL A 1 400 ? 28.17999  7.90305   -13.72225 1.000 30.48441  ? 392 VAL A CG2  1 
ATOM   5901 H  H    . VAL A 1 400 ? 29.44243  5.93024   -14.81331 1.000 48.13172  ? 392 VAL A H    1 
ATOM   5902 H  HA   . VAL A 1 400 ? 31.01153  8.01178   -15.48884 1.000 47.01204  ? 392 VAL A HA   1 
ATOM   5903 H  HB   . VAL A 1 400 ? 29.34641  9.37699   -14.51763 1.000 42.21449  ? 392 VAL A HB   1 
ATOM   5904 H  HG11 . VAL A 1 400 ? 27.64550  9.01869   -16.06727 1.000 44.51996  ? 392 VAL A HG11 1 
ATOM   5905 H  HG12 . VAL A 1 400 ? 29.06593  8.89079   -16.76695 1.000 44.51996  ? 392 VAL A HG12 1 
ATOM   5906 H  HG13 . VAL A 1 400 ? 28.24537  7.58370   -16.39050 1.000 44.51996  ? 392 VAL A HG13 1 
ATOM   5907 H  HG21 . VAL A 1 400 ? 27.36253  8.42523   -13.72423 1.000 36.55810  ? 392 VAL A HG21 1 
ATOM   5908 H  HG22 . VAL A 1 400 ? 27.98265  6.97884   -13.94085 1.000 36.55810  ? 392 VAL A HG22 1 
ATOM   5909 H  HG23 . VAL A 1 400 ? 28.60279  7.95380   -12.85072 1.000 36.55810  ? 392 VAL A HG23 1 
ATOM   5910 N  N    . GLY A 1 401 ? 31.18076  6.74916   -12.64757 1.000 37.92855  ? 393 GLY A N    1 
ATOM   5911 C  CA   . GLY A 1 401 ? 31.86290  6.87235   -11.37541 1.000 38.03000  ? 393 GLY A CA   1 
ATOM   5912 C  C    . GLY A 1 401 ? 31.81314  5.57346   -10.60854 1.000 38.80923  ? 393 GLY A C    1 
ATOM   5913 O  O    . GLY A 1 401 ? 31.33863  4.55428   -11.11039 1.000 38.22144  ? 393 GLY A O    1 
ATOM   5914 H  H    . GLY A 1 401 ? 30.81455  5.98526   -12.79570 1.000 45.49107  ? 393 GLY A H    1 
ATOM   5915 H  HA2  . GLY A 1 401 ? 32.79133  7.11089   -11.52380 1.000 45.61281  ? 393 GLY A HA2  1 
ATOM   5916 H  HA3  . GLY A 1 401 ? 31.44019  7.56446   -10.84324 1.000 45.61281  ? 393 GLY A HA3  1 
ATOM   5917 N  N    . THR A 1 402 ? 32.31159  5.62500   -9.37621  1.000 31.13170  ? 394 THR A N    1 
ATOM   5918 C  CA   . THR A 1 402 ? 32.35269  4.44680   -8.52350  1.000 34.71184  ? 394 THR A CA   1 
ATOM   5919 C  C    . THR A 1 402 ? 32.12930  4.85035   -7.07419  1.000 41.22934  ? 394 THR A C    1 
ATOM   5920 O  O    . THR A 1 402 ? 32.66499  5.86279   -6.61931  1.000 45.02954  ? 394 THR A O    1 
ATOM   5921 C  CB   . THR A 1 402 ? 33.69425  3.72423   -8.66214  1.000 34.69317  ? 394 THR A CB   1 
ATOM   5922 O  OG1  . THR A 1 402 ? 33.78864  3.13012   -9.96310  1.000 42.57071  ? 394 THR A OG1  1 
ATOM   5923 C  CG2  . THR A 1 402 ? 33.83289  2.66463   -7.59272  1.000 40.59153  ? 394 THR A CG2  1 
ATOM   5924 H  H    . THR A 1 402 ? 32.63280  6.33466   -9.01177  1.000 37.33485  ? 394 THR A H    1 
ATOM   5925 H  HA   . THR A 1 402 ? 31.63668  3.84268   -8.77502  1.000 41.63102  ? 394 THR A HA   1 
ATOM   5926 H  HB   . THR A 1 402 ? 34.42236  4.35585   -8.55346  1.000 41.60861  ? 394 THR A HB   1 
ATOM   5927 H  HG1  . THR A 1 402 ? 34.48286  2.66001   -10.01457 1.000 51.06166  ? 394 THR A HG1  1 
ATOM   5928 H  HG21 . THR A 1 402 ? 34.60096  2.10262   -7.78013  1.000 48.68665  ? 394 THR A HG21 1 
ATOM   5929 H  HG22 . THR A 1 402 ? 33.95253  3.08225   -6.72543  1.000 48.68665  ? 394 THR A HG22 1 
ATOM   5930 H  HG23 . THR A 1 402 ? 33.03645  2.11145   -7.56856  1.000 48.68665  ? 394 THR A HG23 1 
ATOM   5931 N  N    . ILE A 1 403 ? 31.33898  4.05211   -6.36043  1.000 41.14903  ? 395 ILE A N    1 
ATOM   5932 C  CA   . ILE A 1 403 ? 31.17087  4.18607   -4.91362  1.000 32.64713  ? 395 ILE A CA   1 
ATOM   5933 C  C    . ILE A 1 403 ? 32.00672  3.05856   -4.32014  1.000 34.91592  ? 395 ILE A C    1 
ATOM   5934 O  O    . ILE A 1 403 ? 31.55365  1.92257   -4.19758  1.000 36.25730  ? 395 ILE A O    1 
ATOM   5935 C  CB   . ILE A 1 403 ? 29.70345  4.11389   -4.49003  1.000 30.85522  ? 395 ILE A CB   1 
ATOM   5936 C  CG1  . ILE A 1 403 ? 28.89430  5.16922   -5.24828  1.000 31.49440  ? 395 ILE A CG1  1 
ATOM   5937 C  CG2  . ILE A 1 403 ? 29.57370  4.32767   -2.98405  1.000 32.64041  ? 395 ILE A CG2  1 
ATOM   5938 C  CD1  . ILE A 1 403 ? 27.42885  5.25475   -4.84711  1.000 26.19412  ? 395 ILE A CD1  1 
ATOM   5939 H  H    . ILE A 1 403 ? 30.87820  3.40970   -6.69896  1.000 49.35564  ? 395 ILE A H    1 
ATOM   5940 H  HA   . ILE A 1 403 ? 31.51931  5.04050   -4.61455  1.000 39.15337  ? 395 ILE A HA   1 
ATOM   5941 H  HB   . ILE A 1 403 ? 29.35836  3.23367   -4.70690  1.000 37.00307  ? 395 ILE A HB   1 
ATOM   5942 H  HG12 . ILE A 1 403 ? 29.29284  6.03859   -5.08619  1.000 37.77010  ? 395 ILE A HG12 1 
ATOM   5943 H  HG13 . ILE A 1 403 ? 28.92639  4.96088   -6.19509  1.000 37.77010  ? 395 ILE A HG13 1 
ATOM   5944 H  HG21 . ILE A 1 403 ? 28.64751  4.20005   -2.72560  1.000 39.14530  ? 395 ILE A HG21 1 
ATOM   5945 H  HG22 . ILE A 1 403 ? 30.13690  3.68558   -2.52425  1.000 39.14530  ? 395 ILE A HG22 1 
ATOM   5946 H  HG23 . ILE A 1 403 ? 29.85615  5.23006   -2.76769  1.000 39.14530  ? 395 ILE A HG23 1 
ATOM   5947 H  HD11 . ILE A 1 403 ? 26.97265  5.86637   -5.44602  1.000 31.40976  ? 395 ILE A HD11 1 
ATOM   5948 H  HD12 . ILE A 1 403 ? 27.03199  4.37193   -4.91064  1.000 31.40976  ? 395 ILE A HD12 1 
ATOM   5949 H  HD13 . ILE A 1 403 ? 27.36956  5.57919   -3.93490  1.000 31.40976  ? 395 ILE A HD13 1 
ATOM   5950 N  N    . GLY A 1 404 ? 33.25389  3.36606   -3.98417  1.000 36.52908  ? 396 GLY A N    1 
ATOM   5951 C  CA   . GLY A 1 404 ? 34.15293  2.35864   -3.45825  1.000 34.37412  ? 396 GLY A CA   1 
ATOM   5952 C  C    . GLY A 1 404 ? 33.67970  1.81328   -2.12888  1.000 32.21213  ? 396 GLY A C    1 
ATOM   5953 O  O    . GLY A 1 404 ? 32.79093  2.34661   -1.46412  1.000 33.06982  ? 396 GLY A O    1 
ATOM   5954 H  H    . GLY A 1 404 ? 33.59982  4.15046   -4.05236  1.000 43.81171  ? 396 GLY A H    1 
ATOM   5955 H  HA2  . GLY A 1 404 ? 34.21589  1.62278   -4.08710  1.000 41.22576  ? 396 GLY A HA2  1 
ATOM   5956 H  HA3  . GLY A 1 404 ? 35.03400  2.74530   -3.33538  1.000 41.22576  ? 396 GLY A HA3  1 
ATOM   5957 N  N    . TYR A 1 405 ? 34.30869  0.71073   -1.73092  1.000 39.68390  ? 397 TYR A N    1 
ATOM   5958 C  CA   . TYR A 1 405 ? 33.92714  0.07132   -0.47963  1.000 38.88433  ? 397 TYR A CA   1 
ATOM   5959 C  C    . TYR A 1 405 ? 34.65649  0.68508   0.70787   1.000 38.43961  ? 397 TYR A C    1 
ATOM   5960 O  O    . TYR A 1 405 ? 34.02873  1.21055   1.63203   1.000 41.13244  ? 397 TYR A O    1 
ATOM   5961 C  CB   . TYR A 1 405 ? 34.21207  -1.42728  -0.53449  1.000 33.56215  ? 397 TYR A CB   1 
ATOM   5962 C  CG   . TYR A 1 405 ? 33.84473  -2.12210  0.75196   1.000 35.53521  ? 397 TYR A CG   1 
ATOM   5963 C  CD1  . TYR A 1 405 ? 32.52616  -2.43600  1.03495   1.000 38.11144  ? 397 TYR A CD1  1 
ATOM   5964 C  CD2  . TYR A 1 405 ? 34.81115  -2.45582  1.69327   1.000 42.73918  ? 397 TYR A CD2  1 
ATOM   5965 C  CE1  . TYR A 1 405 ? 32.17558  -3.07037  2.21641   1.000 27.98008  ? 397 TYR A CE1  1 
ATOM   5966 C  CE2  . TYR A 1 405 ? 34.46294  -3.09342  2.88211   1.000 31.72986  ? 397 TYR A CE2  1 
ATOM   5967 C  CZ   . TYR A 1 405 ? 33.14521  -3.38643  3.13504   1.000 28.09244  ? 397 TYR A CZ   1 
ATOM   5968 O  OH   . TYR A 1 405 ? 32.79417  -4.00994  4.30669   1.000 39.02814  ? 397 TYR A OH   1 
ATOM   5969 H  H    . TYR A 1 405 ? 34.94565  0.32248   -2.15888  1.000 47.59749  ? 397 TYR A H    1 
ATOM   5970 H  HA   . TYR A 1 405 ? 32.97323  0.20036   -0.36000  1.000 46.63801  ? 397 TYR A HA   1 
ATOM   5971 H  HB2  . TYR A 1 405 ? 33.69338  -1.82375  -1.25190  1.000 40.25139  ? 397 TYR A HB2  1 
ATOM   5972 H  HB3  . TYR A 1 405 ? 35.15882  -1.56556  -0.69400  1.000 40.25139  ? 397 TYR A HB3  1 
ATOM   5973 H  HD1  . TYR A 1 405 ? 31.86317  -2.21702  0.42062   1.000 45.71054  ? 397 TYR A HD1  1 
ATOM   5974 H  HD2  . TYR A 1 405 ? 35.70292  -2.25063  1.52727   1.000 51.26383  ? 397 TYR A HD2  1 
ATOM   5975 H  HE1  . TYR A 1 405 ? 31.28587  -3.28126  2.38623   1.000 33.55291  ? 397 TYR A HE1  1 
ATOM   5976 H  HE2  . TYR A 1 405 ? 35.11926  -3.31940  3.50104   1.000 38.05264  ? 397 TYR A HE2  1 
ATOM   5977 H  HH   . TYR A 1 405 ? 33.45217  -4.03271  4.82835   1.000 46.81057  ? 397 TYR A HH   1 
ATOM   5978 N  N    . ALA A 1 406 ? 35.99020  0.62800   0.69326   1.000 41.97783  ? 398 ALA A N    1 
ATOM   5979 C  CA   . ALA A 1 406 ? 36.76159  0.99634   1.87485   1.000 38.90835  ? 398 ALA A CA   1 
ATOM   5980 C  C    . ALA A 1 406 ? 36.50451  2.43305   2.30302   1.000 35.47852  ? 398 ALA A C    1 
ATOM   5981 O  O    . ALA A 1 406 ? 36.64036  2.75550   3.48961   1.000 43.37477  ? 398 ALA A O    1 
ATOM   5982 C  CB   . ALA A 1 406 ? 38.25234  0.78429   1.61305   1.000 38.93440  ? 398 ALA A CB   1 
ATOM   5983 H  H    . ALA A 1 406 ? 36.46471  0.38220   0.01945   1.000 50.35020  ? 398 ALA A H    1 
ATOM   5984 H  HA   . ALA A 1 406 ? 36.49374  0.41830   2.60630   1.000 46.66684  ? 398 ALA A HA   1 
ATOM   5985 H  HB1  . ALA A 1 406 ? 38.75016  1.02340   2.41048   1.000 46.69809  ? 398 ALA A HB1  1 
ATOM   5986 H  HB2  . ALA A 1 406 ? 38.40513  -0.14846  1.39499   1.000 46.69809  ? 398 ALA A HB2  1 
ATOM   5987 H  HB3  . ALA A 1 406 ? 38.52582  1.34646   0.87138   1.000 46.69809  ? 398 ALA A HB3  1 
ATOM   5988 N  N    . GLU A 1 407 ? 36.12901  3.30529   1.36984   1.000 36.10847  ? 399 GLU A N    1 
ATOM   5989 C  CA   . GLU A 1 407 ? 35.93740  4.71220   1.69470   1.000 40.55510  ? 399 GLU A CA   1 
ATOM   5990 C  C    . GLU A 1 407 ? 34.51896  5.02858   2.14091   1.000 40.64414  ? 399 GLU A C    1 
ATOM   5991 O  O    . GLU A 1 407 ? 34.25242  6.17000   2.53460   1.000 47.02874  ? 399 GLU A O    1 
ATOM   5992 C  CB   . GLU A 1 407 ? 36.30281  5.59793   0.49560   1.000 39.61824  ? 399 GLU A CB   1 
ATOM   5993 C  CG   . GLU A 1 407 ? 35.83383  5.07112   -0.85365  1.000 45.23709  ? 399 GLU A CG   1 
ATOM   5994 C  CD   . GLU A 1 407 ? 36.96456  4.46744   -1.66732  1.000 45.33424  ? 399 GLU A CD   1 
ATOM   5995 O  OE1  . GLU A 1 407 ? 36.98686  4.66939   -2.90015  1.000 70.29997  ? 399 GLU A OE1  1 
ATOM   5996 O  OE2  . GLU A 1 407 ? 37.83014  3.78891   -1.07346  1.000 54.26931  ? 399 GLU A OE2  1 
ATOM   5997 H  H    . GLU A 1 407 ? 35.98039  3.10563   0.54664   1.000 43.30698  ? 399 GLU A H    1 
ATOM   5998 H  HA   . GLU A 1 407 ? 36.53824  4.94272   2.42047   1.000 48.64293  ? 399 GLU A HA   1 
ATOM   5999 H  HB2  . GLU A 1 407 ? 35.90012  6.47102   0.62384   1.000 47.51870  ? 399 GLU A HB2  1 
ATOM   6000 H  HB3  . GLU A 1 407 ? 37.26852  5.68044   0.45688   1.000 47.51870  ? 399 GLU A HB3  1 
ATOM   6001 H  HG2  . GLU A 1 407 ? 35.16550  4.38287   -0.71030  1.000 54.26131  ? 399 GLU A HG2  1 
ATOM   6002 H  HG3  . GLU A 1 407 ? 35.45269  5.80241   -1.36438  1.000 54.26131  ? 399 GLU A HG3  1 
ATOM   6003 N  N    . ASN A 1 408 ? 33.60687  4.05794   2.07980   1.000 33.71784  ? 400 ASN A N    1 
ATOM   6004 C  CA   . ASN A 1 408 ? 32.21342  4.28176   2.44001   1.000 37.08252  ? 400 ASN A CA   1 
ATOM   6005 C  C    . ASN A 1 408 ? 31.72955  3.33448   3.52736   1.000 35.27746  ? 400 ASN A C    1 
ATOM   6006 O  O    . ASN A 1 408 ? 30.53746  3.35066   3.86566   1.000 35.52933  ? 400 ASN A O    1 
ATOM   6007 C  CB   . ASN A 1 408 ? 31.33152  4.16168   1.19673   1.000 29.74418  ? 400 ASN A CB   1 
ATOM   6008 C  CG   . ASN A 1 408 ? 31.56457  5.29872   0.20550   1.000 35.36702  ? 400 ASN A CG   1 
ATOM   6009 O  OD1  . ASN A 1 408 ? 31.14713  6.43073   0.43249   1.000 35.11855  ? 400 ASN A OD1  1 
ATOM   6010 N  ND2  . ASN A 1 408 ? 32.24557  4.99888   -0.89285  1.000 40.56969  ? 400 ASN A ND2  1 
ATOM   6011 H  H    . ASN A 1 408 ? 33.77607  3.25281   1.82931   1.000 40.43822  ? 400 ASN A H    1 
ATOM   6012 H  HA   . ASN A 1 408 ? 32.12037  5.18269   2.78723   1.000 44.47583  ? 400 ASN A HA   1 
ATOM   6013 H  HB2  . ASN A 1 408 ? 31.52873  3.32499   0.74734   1.000 35.66983  ? 400 ASN A HB2  1 
ATOM   6014 H  HB3  . ASN A 1 408 ? 30.39970  4.18237   1.46539   1.000 35.66983  ? 400 ASN A HB3  1 
ATOM   6015 H  HD21 . ASN A 1 408 ? 32.40208  5.60643   -1.48106  1.000 48.66044  ? 400 ASN A HD21 1 
ATOM   6016 H  HD22 . ASN A 1 408 ? 32.53052  4.19695   -1.01665  1.000 48.66044  ? 400 ASN A HD22 1 
ATOM   6017 N  N    . VAL A 1 409 ? 32.62561  2.52993   4.09719   1.000 31.21734  ? 401 VAL A N    1 
ATOM   6018 C  CA   . VAL A 1 409 ? 32.28691  1.72959   5.26395   1.000 35.13611  ? 401 VAL A CA   1 
ATOM   6019 C  C    . VAL A 1 409 ? 32.14215  2.63773   6.48024   1.000 44.52876  ? 401 VAL A C    1 
ATOM   6020 O  O    . VAL A 1 409 ? 32.95269  3.54796   6.70024   1.000 43.55458  ? 401 VAL A O    1 
ATOM   6021 C  CB   . VAL A 1 409 ? 33.36270  0.65396   5.49518   1.000 45.04243  ? 401 VAL A CB   1 
ATOM   6022 C  CG1  . VAL A 1 409 ? 34.75867  1.26639   5.41413   1.000 63.42760  ? 401 VAL A CG1  1 
ATOM   6023 C  CG2  . VAL A 1 409 ? 33.14621  -0.02740  6.84533   1.000 55.63364  ? 401 VAL A CG2  1 
ATOM   6024 H  H    . VAL A 1 409 ? 33.43555  2.43152   3.82532   1.000 37.43762  ? 401 VAL A H    1 
ATOM   6025 H  HA   . VAL A 1 409 ? 31.43809  1.28485   5.11360   1.000 42.14014  ? 401 VAL A HA   1 
ATOM   6026 H  HB   . VAL A 1 409 ? 33.29233  -0.01964  4.80076   1.000 54.02773  ? 401 VAL A HB   1 
ATOM   6027 H  HG11 . VAL A 1 409 ? 35.41602  0.58161   5.61378   1.000 76.08993  ? 401 VAL A HG11 1 
ATOM   6028 H  HG12 . VAL A 1 409 ? 34.90105  1.61049   4.51846   1.000 76.08993  ? 401 VAL A HG12 1 
ATOM   6029 H  HG13 . VAL A 1 409 ? 34.82529  1.98715   6.05986   1.000 76.08993  ? 401 VAL A HG13 1 
ATOM   6030 H  HG21 . VAL A 1 409 ? 33.81768  -0.71763  6.96201   1.000 66.73717  ? 401 VAL A HG21 1 
ATOM   6031 H  HG22 . VAL A 1 409 ? 33.22656  0.63468   7.54967   1.000 66.73717  ? 401 VAL A HG22 1 
ATOM   6032 H  HG23 . VAL A 1 409 ? 32.26015  -0.42177  6.86157   1.000 66.73717  ? 401 VAL A HG23 1 
ATOM   6033 N  N    . THR A 1 410 ? 31.10197  2.39891   7.28027   1.000 44.02825  ? 402 THR A N    1 
ATOM   6034 C  CA   . THR A 1 410 ? 30.91612  3.12755   8.53435   1.000 45.76166  ? 402 THR A CA   1 
ATOM   6035 C  C    . THR A 1 410 ? 31.82615  2.50700   9.58882   1.000 53.27560  ? 402 THR A C    1 
ATOM   6036 O  O    . THR A 1 410 ? 31.58719  1.38165   10.04164  1.000 50.22494  ? 402 THR A O    1 
ATOM   6037 C  CB   . THR A 1 410 ? 29.45681  3.08952   8.98170   1.000 42.64396  ? 402 THR A CB   1 
ATOM   6038 O  OG1  . THR A 1 410 ? 29.10284  1.74695   9.34204   1.000 47.77423  ? 402 THR A OG1  1 
ATOM   6039 C  CG2  . THR A 1 410 ? 28.53926  3.58635   7.86001   1.000 39.01367  ? 402 THR A CG2  1 
ATOM   6040 H  H    . THR A 1 410 ? 30.48891  1.81808   7.11779   1.000 52.81071  ? 402 THR A H    1 
ATOM   6041 H  HA   . THR A 1 410 ? 31.16201  4.05687   8.40474   1.000 54.89080  ? 402 THR A HA   1 
ATOM   6042 H  HB   . THR A 1 410 ? 29.33337  3.66920   9.74958   1.000 51.14956  ? 402 THR A HB   1 
ATOM   6043 H  HG1  . THR A 1 410 ? 28.28911  1.70957   9.54708   1.000 57.30589  ? 402 THR A HG1  1 
ATOM   6044 H  HG21 . THR A 1 410 ? 27.63315  3.68511   8.19186   1.000 46.79322  ? 402 THR A HG21 1 
ATOM   6045 H  HG22 . THR A 1 410 ? 28.85008  4.44503   7.53299   1.000 46.79322  ? 402 THR A HG22 1 
ATOM   6046 H  HG23 . THR A 1 410 ? 28.53843  2.95167   7.12647   1.000 46.79322  ? 402 THR A HG23 1 
ATOM   6047 N  N    . HIS A 1 411 ? 32.87663  3.22924   9.96830   1.000 56.88942  ? 403 HIS A N    1 
ATOM   6048 C  CA   . HIS A 1 411 ? 33.86837  2.70837   10.90329  1.000 69.73624  ? 403 HIS A CA   1 
ATOM   6049 C  C    . HIS A 1 411 ? 33.58107  3.20303   12.31494  1.000 72.58306  ? 403 HIS A C    1 
ATOM   6050 O  O    . HIS A 1 411 ? 32.48497  3.00568   12.83875  1.000 69.08953  ? 403 HIS A O    1 
ATOM   6051 C  CB   . HIS A 1 411 ? 35.27937  3.12027   10.47506  1.000 69.57595  ? 403 HIS A CB   1 
ATOM   6052 C  CG   . HIS A 1 411 ? 35.94145  2.14772   9.54558   1.000 77.25311  ? 403 HIS A CG   1 
ATOM   6053 N  ND1  . HIS A 1 411 ? 36.95162  2.51467   8.68209   1.000 76.98274  ? 403 HIS A ND1  1 
ATOM   6054 C  CD2  . HIS A 1 411 ? 35.74398  0.82194   9.34901   1.000 77.52540  ? 403 HIS A CD2  1 
ATOM   6055 C  CE1  . HIS A 1 411 ? 37.34721  1.45835   7.99438   1.000 74.95983  ? 403 HIS A CE1  1 
ATOM   6056 N  NE2  . HIS A 1 411 ? 36.62842  0.41865   8.37800   1.000 85.19892  ? 403 HIS A NE2  1 
ATOM   6057 H  H    . HIS A 1 411 ? 33.03843  4.02899   9.69660   1.000 68.24412  ? 403 HIS A H    1 
ATOM   6058 H  HA   . HIS A 1 411 ? 33.83088  1.73910   10.90538  1.000 83.66030  ? 403 HIS A HA   1 
ATOM   6059 H  HB2  . HIS A 1 411 ? 35.22932  3.97574   10.02057  1.000 83.46795  ? 403 HIS A HB2  1 
ATOM   6060 H  HB3  . HIS A 1 411 ? 35.83478  3.19710   11.26658  1.000 83.46795  ? 403 HIS A HB3  1 
ATOM   6061 H  HD2  . HIS A 1 411 ? 35.12524  0.28500   9.78919   1.000 93.00729  ? 403 HIS A HD2  1 
ATOM   6062 H  HE1  . HIS A 1 411 ? 38.01762  1.44843   7.34990   1.000 89.92861  ? 403 HIS A HE1  1 
ATOM   6063 N  N    . VAL A 1 417 ? 30.40937  -9.34297  12.16564  1.000 39.66670  ? 409 VAL A N    1 
ATOM   6064 C  CA   . VAL A 1 417 ? 29.53738  -8.60530  13.07445  1.000 40.59672  ? 409 VAL A CA   1 
ATOM   6065 C  C    . VAL A 1 417 ? 28.07168  -8.99526  12.83910  1.000 40.68218  ? 409 VAL A C    1 
ATOM   6066 O  O    . VAL A 1 417 ? 27.28265  -9.02909  13.78393  1.000 39.69377  ? 409 VAL A O    1 
ATOM   6067 C  CB   . VAL A 1 417 ? 29.72701  -7.09443  12.92386  1.000 43.16838  ? 409 VAL A CB   1 
ATOM   6068 C  CG1  . VAL A 1 417 ? 29.19857  -6.60941  11.57114  1.000 48.45363  ? 409 VAL A CG1  1 
ATOM   6069 C  CG2  . VAL A 1 417 ? 29.04301  -6.35931  14.05289  1.000 40.83109  ? 409 VAL A CG2  1 
ATOM   6070 H  HA   . VAL A 1 417 ? 29.77106  -8.84111  13.98587  1.000 48.69288  ? 409 VAL A HA   1 
ATOM   6071 H  HB   . VAL A 1 417 ? 30.67616  -6.89810  12.96209  1.000 51.77886  ? 409 VAL A HB   1 
ATOM   6072 H  HG11 . VAL A 1 417 ? 29.40507  -5.66696  11.47094  1.000 58.12117  ? 409 VAL A HG11 1 
ATOM   6073 H  HG12 . VAL A 1 417 ? 29.62543  -7.11853  10.86439  1.000 58.12117  ? 409 VAL A HG12 1 
ATOM   6074 H  HG13 . VAL A 1 417 ? 28.23823  -6.74263  11.54108  1.000 58.12117  ? 409 VAL A HG13 1 
ATOM   6075 H  HG21 . VAL A 1 417 ? 29.17233  -5.40549  13.93282  1.000 48.97412  ? 409 VAL A HG21 1 
ATOM   6076 H  HG22 . VAL A 1 417 ? 28.09608  -6.56913  14.03846  1.000 48.97412  ? 409 VAL A HG22 1 
ATOM   6077 H  HG23 . VAL A 1 417 ? 29.43173  -6.64236  14.89531  1.000 48.97412  ? 409 VAL A HG23 1 
ATOM   6078 N  N    . LEU A 1 418 ? 27.70038  -9.27926  11.58643  1.000 42.33065  ? 410 LEU A N    1 
ATOM   6079 C  CA   . LEU A 1 418 ? 26.35062  -9.75413  11.30683  1.000 31.10759  ? 410 LEU A CA   1 
ATOM   6080 C  C    . LEU A 1 418 ? 26.05390  -11.02696 12.08995  1.000 37.93422  ? 410 LEU A C    1 
ATOM   6081 O  O    . LEU A 1 418 ? 25.02941  -11.14275 12.76538  1.000 31.88522  ? 410 LEU A O    1 
ATOM   6082 C  CB   . LEU A 1 418 ? 26.18545  -10.01391 9.81223   1.000 30.12449  ? 410 LEU A CB   1 
ATOM   6083 C  CG   . LEU A 1 418 ? 24.79893  -10.48767 9.38467   1.000 29.12309  ? 410 LEU A CG   1 
ATOM   6084 C  CD1  . LEU A 1 418 ? 23.76224  -9.40691  9.66658   1.000 35.98871  ? 410 LEU A CD1  1 
ATOM   6085 C  CD2  . LEU A 1 418 ? 24.77298  -10.88468 7.92229   1.000 37.22887  ? 410 LEU A CD2  1 
ATOM   6086 H  H    . LEU A 1 418 ? 28.20536  -9.20554  10.89422  1.000 50.77359  ? 410 LEU A H    1 
ATOM   6087 H  HA   . LEU A 1 418 ? 25.71810  -9.06789  11.57123  1.000 37.30592  ? 410 LEU A HA   1 
ATOM   6088 H  HB2  . LEU A 1 418 ? 26.37036  -9.18910  9.33642   1.000 36.12620  ? 410 LEU A HB2  1 
ATOM   6089 H  HB3  . LEU A 1 418 ? 26.82047  -10.69828 9.54900   1.000 36.12620  ? 410 LEU A HB3  1 
ATOM   6090 H  HG   . LEU A 1 418 ? 24.57046  -11.27693 9.90020   1.000 34.92452  ? 410 LEU A HG   1 
ATOM   6091 H  HD11 . LEU A 1 418 ? 22.89785  -9.70671  9.34433   1.000 43.16327  ? 410 LEU A HD11 1 
ATOM   6092 H  HD12 . LEU A 1 418 ? 23.72229  -9.24940  10.62287  1.000 43.16327  ? 410 LEU A HD12 1 
ATOM   6093 H  HD13 . LEU A 1 418 ? 24.02207  -8.59272  9.20781   1.000 43.16327  ? 410 LEU A HD13 1 
ATOM   6094 H  HD21 . LEU A 1 418 ? 23.85962  -11.08746 7.66627   1.000 44.65145  ? 410 LEU A HD21 1 
ATOM   6095 H  HD22 . LEU A 1 418 ? 25.11018  -10.14792 7.38901   1.000 44.65145  ? 410 LEU A HD22 1 
ATOM   6096 H  HD23 . LEU A 1 418 ? 25.33293  -11.66683 7.79741   1.000 44.65145  ? 410 LEU A HD23 1 
ATOM   6097 N  N    . SER A 1 419 ? 26.92921  -12.01426 11.94037  1.000 36.12760  ? 411 SER A N    1 
ATOM   6098 C  CA   . SER A 1 419 ? 26.96705  -13.18021 12.83158  1.000 32.06995  ? 411 SER A CA   1 
ATOM   6099 C  C    . SER A 1 419 ? 26.57176  -12.86760 14.28996  1.000 29.35792  ? 411 SER A C    1 
ATOM   6100 O  O    . SER A 1 419 ? 25.59343  -13.38410 14.81744  1.000 26.69186  ? 411 SER A O    1 
ATOM   6101 C  CB   . SER A 1 419 ? 28.36536  -13.72485 12.86978  1.000 32.36508  ? 411 SER A CB   1 
ATOM   6102 O  OG   . SER A 1 419 ? 29.29295  -12.61597 13.06598  1.000 62.20523  ? 411 SER A OG   1 
ATOM   6103 H  H    . SER A 1 419 ? 27.52537  -12.03921 11.32104  1.000 43.32993  ? 411 SER A H    1 
ATOM   6104 H  HA   . SER A 1 419 ? 26.33549  -13.82054 12.46824  1.000 38.46075  ? 411 SER A HA   1 
ATOM   6105 H  HB2  . SER A 1 419 ? 28.44929  -14.35201 13.60500  1.000 38.81491  ? 411 SER A HB2  1 
ATOM   6106 H  HB3  . SER A 1 419 ? 28.56357  -14.16904 12.03055  1.000 38.81491  ? 411 SER A HB3  1 
ATOM   6107 H  HG   . SER A 1 419 ? 29.18245  -12.03926 12.46532  1.000 74.62308  ? 411 SER A HG   1 
ATOM   6108 N  N    . GLU A 1 420 ? 27.21246  -11.87526 14.87585  1.000 28.57522  ? 412 GLU A N    1 
ATOM   6109 C  CA   . GLU A 1 420 ? 26.96204  -11.54435 16.26883  1.000 34.24301  ? 412 GLU A CA   1 
ATOM   6110 C  C    . GLU A 1 420 ? 25.58627  -10.91767 16.46507  1.000 29.32652  ? 412 GLU A C    1 
ATOM   6111 O  O    . GLU A 1 420 ? 24.89181  -11.20331 17.44413  1.000 31.40332  ? 412 GLU A O    1 
ATOM   6112 C  CB   . GLU A 1 420 ? 28.06619  -10.59266 16.71344  1.000 43.07884  ? 412 GLU A CB   1 
ATOM   6113 C  CG   . GLU A 1 420 ? 29.49126  -11.13917 16.56554  1.000 45.16935  ? 412 GLU A CG   1 
ATOM   6114 C  CD   . GLU A 1 420 ? 30.55789  -10.15207 17.03365  1.000 46.80175  ? 412 GLU A CD   1 
ATOM   6115 O  OE1  . GLU A 1 420 ? 30.45969  -8.95714  16.68447  1.000 53.82611  ? 412 GLU A OE1  1 
ATOM   6116 O  OE2  . GLU A 1 420 ? 31.49205  -10.57256 17.75205  1.000 41.67885  ? 412 GLU A OE2  1 
ATOM   6117 H  H    . GLU A 1 420 ? 27.79803  -11.37544 14.49258  1.000 34.26708  ? 412 GLU A H    1 
ATOM   6118 H  HA   . GLU A 1 420 ? 26.97744  -12.34564 16.81527  1.000 41.06842  ? 412 GLU A HA   1 
ATOM   6119 H  HB2  . GLU A 1 420 ? 28.00789  -9.78440  16.18032  1.000 51.67142  ? 412 GLU A HB2  1 
ATOM   6120 H  HB3  . GLU A 1 420 ? 27.93119  -10.38235 17.65069  1.000 51.67142  ? 412 GLU A HB3  1 
ATOM   6121 H  HG2  . GLU A 1 420 ? 29.57644  -11.94617 17.09694  1.000 54.18003  ? 412 GLU A HG2  1 
ATOM   6122 H  HG3  . GLU A 1 420 ? 29.65737  -11.33835 15.63085  1.000 54.18003  ? 412 GLU A HG3  1 
ATOM   6123 N  N    . LYS A 1 421 ? 25.16964  -10.08075 15.50902  1.000 30.04858  ? 413 LYS A N    1 
ATOM   6124 C  CA   . LYS A 1 421 ? 23.89319  -9.38970  15.65156  1.000 23.07754  ? 413 LYS A CA   1 
ATOM   6125 C  C    . LYS A 1 421 ? 22.73042  -10.36535 15.55137  1.000 27.65192  ? 413 LYS A C    1 
ATOM   6126 O  O    . LYS A 1 421 ? 21.74397  -10.23744 16.28656  1.000 26.51148  ? 413 LYS A O    1 
ATOM   6127 C  CB   . LYS A 1 421 ? 23.75230  -8.28517  14.60404  1.000 25.89214  ? 413 LYS A CB   1 
ATOM   6128 C  CG   . LYS A 1 421 ? 22.77782  -7.18506  14.99937  1.000 28.19064  ? 413 LYS A CG   1 
ATOM   6129 C  CD   . LYS A 1 421 ? 22.61864  -6.16970  13.88096  1.000 29.67951  ? 413 LYS A CD   1 
ATOM   6130 C  CE   . LYS A 1 421 ? 22.00154  -4.87369  14.38306  1.000 25.88348  ? 413 LYS A CE   1 
ATOM   6131 N  NZ   . LYS A 1 421 ? 22.91975  -4.10212  15.27457  1.000 22.75065  ? 413 LYS A NZ   1 
ATOM   6132 H  H    . LYS A 1 421 ? 25.59955  -9.90187  14.78598  1.000 36.03511  ? 413 LYS A H    1 
ATOM   6133 H  HA   . LYS A 1 421 ? 23.87024  -8.96879  16.52517  1.000 27.66985  ? 413 LYS A HA   1 
ATOM   6134 H  HB2  . LYS A 1 421 ? 24.62038  -7.87554  14.46432  1.000 31.04738  ? 413 LYS A HB2  1 
ATOM   6135 H  HB3  . LYS A 1 421 ? 23.43428  -8.67905  13.77662  1.000 31.04738  ? 413 LYS A HB3  1 
ATOM   6136 H  HG2  . LYS A 1 421 ? 21.90929  -7.57457  15.18601  1.000 33.80558  ? 413 LYS A HG2  1 
ATOM   6137 H  HG3  . LYS A 1 421 ? 23.11122  -6.72545  15.78582  1.000 33.80558  ? 413 LYS A HG3  1 
ATOM   6138 H  HD2  . LYS A 1 421 ? 23.48982  -5.96649  13.50591  1.000 35.59223  ? 413 LYS A HD2  1 
ATOM   6139 H  HD3  . LYS A 1 421 ? 22.03943  -6.53657  13.19479  1.000 35.59223  ? 413 LYS A HD3  1 
ATOM   6140 H  HE2  . LYS A 1 421 ? 21.78124  -4.31310  13.62273  1.000 31.03698  ? 413 LYS A HE2  1 
ATOM   6141 H  HE3  . LYS A 1 421 ? 21.19865  -5.08019  14.88668  1.000 31.03698  ? 413 LYS A HE3  1 
ATOM   6142 H  HZ1  . LYS A 1 421 ? 22.58057  -3.29524  15.43584  1.000 27.27759  ? 413 LYS A HZ1  1 
ATOM   6143 H  HZ2  . LYS A 1 421 ? 23.02515  -4.53086  16.04734  1.000 27.27759  ? 413 LYS A HZ2  1 
ATOM   6144 H  HZ3  . LYS A 1 421 ? 23.71465  -4.00875  14.88530  1.000 27.27759  ? 413 LYS A HZ3  1 
ATOM   6145 N  N    . ILE A 1 422 ? 22.82598  -11.34974 14.65346  1.000 23.78083  ? 414 ILE A N    1 
ATOM   6146 C  CA   . ILE A 1 422 ? 21.76385  -12.34442 14.54799  1.000 25.12336  ? 414 ILE A CA   1 
ATOM   6147 C  C    . ILE A 1 422 ? 21.70704  -13.17857 15.81805  1.000 27.25055  ? 414 ILE A C    1 
ATOM   6148 O  O    . ILE A 1 422 ? 20.62291  -13.49944 16.32047  1.000 28.34144  ? 414 ILE A O    1 
ATOM   6149 C  CB   . ILE A 1 422 ? 21.96614  -13.21999 13.29586  1.000 22.90026  ? 414 ILE A CB   1 
ATOM   6150 C  CG1  . ILE A 1 422 ? 21.86381  -12.35106 12.03558  1.000 29.95230  ? 414 ILE A CG1  1 
ATOM   6151 C  CG2  . ILE A 1 422 ? 20.93810  -14.34361 13.25275  1.000 22.67183  ? 414 ILE A CG2  1 
ATOM   6152 C  CD1  . ILE A 1 422 ? 22.30839  -13.04255 10.75728  1.000 33.02074  ? 414 ILE A CD1  1 
ATOM   6153 H  H    . ILE A 1 422 ? 23.48113  -11.45957 14.10728  1.000 28.51381  ? 414 ILE A H    1 
ATOM   6154 H  HA   . ILE A 1 422 ? 20.91509  -11.88556 14.44821  1.000 30.12484  ? 414 ILE A HA   1 
ATOM   6155 H  HB   . ILE A 1 422 ? 22.84929  -13.61919 13.33564  1.000 27.45713  ? 414 ILE A HB   1 
ATOM   6156 H  HG12 . ILE A 1 422 ? 20.93861  -12.08442 11.91809  1.000 35.91957  ? 414 ILE A HG12 1 
ATOM   6157 H  HG13 . ILE A 1 422 ? 22.42251  -11.56706 12.15431  1.000 35.91957  ? 414 ILE A HG13 1 
ATOM   6158 H  HG21 . ILE A 1 422 ? 21.04756  -14.84027 12.42676  1.000 27.18300  ? 414 ILE A HG21 1 
ATOM   6159 H  HG22 . ILE A 1 422 ? 21.07912  -14.92999 14.01247  1.000 27.18300  ? 414 ILE A HG22 1 
ATOM   6160 H  HG23 . ILE A 1 422 ? 20.04836  -13.95928 13.29220  1.000 27.18300  ? 414 ILE A HG23 1 
ATOM   6161 H  HD11 . ILE A 1 422 ? 22.24299  -12.41567 10.01996  1.000 39.60170  ? 414 ILE A HD11 1 
ATOM   6162 H  HD12 . ILE A 1 422 ? 23.22680  -13.33709 10.86056  1.000 39.60170  ? 414 ILE A HD12 1 
ATOM   6163 H  HD13 . ILE A 1 422 ? 21.73252  -13.80594 10.59448  1.000 39.60170  ? 414 ILE A HD13 1 
ATOM   6164 N  N    . GLN A 1 423 ? 22.87240  -13.54286 16.35773  1.000 32.59760  ? 415 GLN A N    1 
ATOM   6165 C  CA   . GLN A 1 423 ? 22.90474  -14.33985 17.57903  1.000 38.81462  ? 415 GLN A CA   1 
ATOM   6166 C  C    . GLN A 1 423 ? 22.26839  -13.57540 18.73286  1.000 29.74799  ? 415 GLN A C    1 
ATOM   6167 O  O    . GLN A 1 423 ? 21.44807  -14.11520 19.48356  1.000 29.81100  ? 415 GLN A O    1 
ATOM   6168 C  CB   . GLN A 1 423 ? 24.35115  -14.72620 17.91065  1.000 33.83583  ? 415 GLN A CB   1 
ATOM   6169 C  CG   . GLN A 1 423 ? 24.98171  -15.67448 16.91394  1.000 40.65199  ? 415 GLN A CG   1 
ATOM   6170 C  CD   . GLN A 1 423 ? 26.40260  -16.07133 17.30899  1.000 59.83089  ? 415 GLN A CD   1 
ATOM   6171 O  OE1  . GLN A 1 423 ? 27.11610  -15.30309 17.95967  1.000 58.59843  ? 415 GLN A OE1  1 
ATOM   6172 N  NE2  . GLN A 1 423 ? 26.81241  -17.27878 16.92633  1.000 56.83514  ? 415 GLN A NE2  1 
ATOM   6173 H  H    . GLN A 1 423 ? 23.64606  -13.34343 16.03951  1.000 39.09393  ? 415 GLN A H    1 
ATOM   6174 H  HA   . GLN A 1 423 ? 22.40202  -15.15811 17.44258  1.000 46.55435  ? 415 GLN A HA   1 
ATOM   6175 H  HB2  . GLN A 1 423 ? 24.89052  -13.92028 17.93249  1.000 40.57981  ? 415 GLN A HB2  1 
ATOM   6176 H  HB3  . GLN A 1 423 ? 24.36568  -15.15876 18.77875  1.000 40.57981  ? 415 GLN A HB3  1 
ATOM   6177 H  HG2  . GLN A 1 423 ? 24.44662  -16.48181 16.86114  1.000 48.75919  ? 415 GLN A HG2  1 
ATOM   6178 H  HG3  . GLN A 1 423 ? 25.01913  -15.24388 16.04556  1.000 48.75919  ? 415 GLN A HG3  1 
ATOM   6179 H  HE21 . GLN A 1 423 ? 26.28466  -17.79058 16.48009  1.000 68.17897  ? 415 GLN A HE21 1 
ATOM   6180 H  HE22 . GLN A 1 423 ? 27.60491  -17.54699 17.12538  1.000 68.17897  ? 415 GLN A HE22 1 
ATOM   6181 N  N    . GLN A 1 424 ? 22.62885  -12.30317 18.87858  1.000 23.92888  ? 416 GLN A N    1 
ATOM   6182 C  CA   . GLN A 1 424 ? 22.05628  -11.49722 19.95045  1.000 33.14684  ? 416 GLN A CA   1 
ATOM   6183 C  C    . GLN A 1 424 ? 20.54035  -11.37666 19.80959  1.000 31.26970  ? 416 GLN A C    1 
ATOM   6184 O  O    . GLN A 1 424 ? 19.80612  -11.41976 20.80450  1.000 23.40216  ? 416 GLN A O    1 
ATOM   6185 C  CB   . GLN A 1 424 ? 22.70852  -10.11287 19.95590  1.000 27.10611  ? 416 GLN A CB   1 
ATOM   6186 C  CG   . GLN A 1 424 ? 22.43885  -9.29476  21.22203  1.000 40.99538  ? 416 GLN A CG   1 
ATOM   6187 C  CD   . GLN A 1 424 ? 22.34796  -7.80874  20.95601  1.000 39.35498  ? 416 GLN A CD   1 
ATOM   6188 O  OE1  . GLN A 1 424 ? 21.59939  -7.09658  21.62359  1.000 46.76494  ? 416 GLN A OE1  1 
ATOM   6189 N  NE2  . GLN A 1 424 ? 23.10904  -7.33002  19.97695  1.000 36.81139  ? 416 GLN A NE2  1 
ATOM   6190 H  H    . GLN A 1 424 ? 23.19340  -11.88945 18.37886  1.000 28.69146  ? 416 GLN A H    1 
ATOM   6191 H  HA   . GLN A 1 424 ? 22.24024  -11.92628 20.80073  1.000 39.75302  ? 416 GLN A HA   1 
ATOM   6192 H  HB2  . GLN A 1 424 ? 23.66897  -10.22264 19.87591  1.000 32.50414  ? 416 GLN A HB2  1 
ATOM   6193 H  HB3  . GLN A 1 424 ? 22.36840  -9.60721  19.20124  1.000 32.50414  ? 416 GLN A HB3  1 
ATOM   6194 H  HG2  . GLN A 1 424 ? 21.59691  -9.58132  21.60924  1.000 49.17127  ? 416 GLN A HG2  1 
ATOM   6195 H  HG3  . GLN A 1 424 ? 23.16116  -9.44211  21.85246  1.000 49.17127  ? 416 GLN A HG3  1 
ATOM   6196 H  HE21 . GLN A 1 424 ? 23.61961  -7.85938  19.53120  1.000 44.15047  ? 416 GLN A HE21 1 
ATOM   6197 H  HE22 . GLN A 1 424 ? 23.09086  -6.49094  19.78928  1.000 44.15047  ? 416 GLN A HE22 1 
ATOM   6198 N  N    . TYR A 1 425 ? 20.05578  -11.18935 18.58398  1.000 27.93272  ? 417 TYR A N    1 
ATOM   6199 C  CA   . TYR A 1 425 ? 18.61788  -11.09454 18.36313  1.000 26.05636  ? 417 TYR A CA   1 
ATOM   6200 C  C    . TYR A 1 425 ? 17.94060  -12.43011 18.64657  1.000 24.21458  ? 417 TYR A C    1 
ATOM   6201 O  O    . TYR A 1 425 ? 16.91141  -12.48832 19.33120  1.000 22.34323  ? 417 TYR A O    1 
ATOM   6202 C  CB   . TYR A 1 425 ? 18.35130  -10.64252 16.92410  1.000 24.72423  ? 417 TYR A CB   1 
ATOM   6203 C  CG   . TYR A 1 425 ? 16.88351  -10.59655 16.55020  1.000 27.82338  ? 417 TYR A CG   1 
ATOM   6204 C  CD1  . TYR A 1 425 ? 16.13581  -9.43310  16.73963  1.000 18.79683  ? 417 TYR A CD1  1 
ATOM   6205 C  CD2  . TYR A 1 425 ? 16.24138  -11.71573 16.01534  1.000 27.85729  ? 417 TYR A CD2  1 
ATOM   6206 C  CE1  . TYR A 1 425 ? 14.81014  -9.37791  16.40975  1.000 18.20144  ? 417 TYR A CE1  1 
ATOM   6207 C  CE2  . TYR A 1 425 ? 14.89886  -11.66813 15.68250  1.000 26.31922  ? 417 TYR A CE2  1 
ATOM   6208 C  CZ   . TYR A 1 425 ? 14.19067  -10.49081 15.88383  1.000 21.99910  ? 417 TYR A CZ   1 
ATOM   6209 O  OH   . TYR A 1 425 ? 12.85396  -10.41973 15.56565  1.000 27.18014  ? 417 TYR A OH   1 
ATOM   6210 H  H    . TYR A 1 425 ? 20.53281  -11.11486 17.87230  1.000 33.49608  ? 417 TYR A H    1 
ATOM   6211 H  HA   . TYR A 1 425 ? 18.24030  -10.43279 18.96347  1.000 31.24444  ? 417 TYR A HA   1 
ATOM   6212 H  HB2  . TYR A 1 425 ? 18.71292  -9.75008  16.80717  1.000 29.64589  ? 417 TYR A HB2  1 
ATOM   6213 H  HB3  . TYR A 1 425 ? 18.79010  -11.26027 16.31850  1.000 29.64589  ? 417 TYR A HB3  1 
ATOM   6214 H  HD1  . TYR A 1 425 ? 16.54785  -8.68010  17.09754  1.000 22.53301  ? 417 TYR A HD1  1 
ATOM   6215 H  HD2  . TYR A 1 425 ? 16.72103  -12.50117 15.88147  1.000 33.40556  ? 417 TYR A HD2  1 
ATOM   6216 H  HE1  . TYR A 1 425 ? 14.32870  -8.59291  16.53970  1.000 21.81854  ? 417 TYR A HE1  1 
ATOM   6217 H  HE2  . TYR A 1 425 ? 14.47565  -12.41649 15.32787  1.000 31.55987  ? 417 TYR A HE2  1 
ATOM   6218 H  HH   . TYR A 1 425 ? 12.54904  -11.19094 15.43201  1.000 32.59298  ? 417 TYR A HH   1 
ATOM   6219 N  N    . ASP A 1 426 ? 18.50936  -13.51864 18.12002  1.000 29.03942  ? 418 ASP A N    1 
ATOM   6220 C  CA   . ASP A 1 426 ? 17.88297  -14.82938 18.26576  1.000 30.30926  ? 418 ASP A CA   1 
ATOM   6221 C  C    . ASP A 1 426 ? 17.89664  -15.30268 19.71367  1.000 31.20568  ? 418 ASP A C    1 
ATOM   6222 O  O    . ASP A 1 426 ? 17.03053  -16.09261 20.11181  1.000 33.35889  ? 418 ASP A O    1 
ATOM   6223 C  CB   . ASP A 1 426 ? 18.58478  -15.85732 17.37274  1.000 30.91146  ? 418 ASP A CB   1 
ATOM   6224 C  CG   . ASP A 1 426 ? 18.25816  -15.67566 15.91130  1.000 25.97051  ? 418 ASP A CG   1 
ATOM   6225 O  OD1  . ASP A 1 426 ? 17.29846  -14.94979 15.61626  1.000 33.21982  ? 418 ASP A OD1  1 
ATOM   6226 O  OD2  . ASP A 1 426 ? 18.95063  -16.25055 15.05067  1.000 28.92359  ? 418 ASP A OD2  1 
ATOM   6227 H  H    . ASP A 1 426 ? 19.24817  -13.52330 17.67987  1.000 34.82412  ? 418 ASP A H    1 
ATOM   6228 H  HA   . ASP A 1 426 ? 16.95941  -14.76059 17.97730  1.000 36.34793  ? 418 ASP A HA   1 
ATOM   6229 H  HB2  . ASP A 1 426 ? 19.54460  -15.76668 17.47964  1.000 37.07056  ? 418 ASP A HB2  1 
ATOM   6230 H  HB3  . ASP A 1 426 ? 18.30444  -16.74818 17.63480  1.000 37.07056  ? 418 ASP A HB3  1 
ATOM   6231 N  N    . ASN A 1 427 ? 18.84963  -14.82327 20.51813  1.000 29.59932  ? 419 ASN A N    1 
ATOM   6232 C  CA   . ASN A 1 427 ? 18.97872  -15.24704 21.90705  1.000 31.58087  ? 419 ASN A CA   1 
ATOM   6233 C  C    . ASN A 1 427 ? 18.66843  -14.12532 22.88521  1.000 30.43194  ? 419 ASN A C    1 
ATOM   6234 O  O    . ASN A 1 427 ? 19.07346  -14.19243 24.04949  1.000 32.32011  ? 419 ASN A O    1 
ATOM   6235 C  CB   . ASN A 1 427 ? 20.37960  -15.79406 22.17298  1.000 32.65135  ? 419 ASN A CB   1 
ATOM   6236 C  CG   . ASN A 1 427 ? 20.61116  -17.13109 21.50744  1.000 31.48614  ? 419 ASN A CG   1 
ATOM   6237 O  OD1  . ASN A 1 427 ? 20.08531  -18.15915 21.94021  1.000 43.83605  ? 419 ASN A OD1  1 
ATOM   6238 N  ND2  . ASN A 1 427 ? 21.39824  -17.12552 20.44563  1.000 36.10976  ? 419 ASN A ND2  1 
ATOM   6239 H  H    . ASN A 1 427 ? 19.43803  -14.24495 20.27539  1.000 35.49599  ? 419 ASN A H    1 
ATOM   6240 H  HA   . ASN A 1 427 ? 18.34187  -15.96224 22.06134  1.000 37.87385  ? 419 ASN A HA   1 
ATOM   6241 H  HB2  . ASN A 1 427 ? 21.03563  -15.16810 21.82845  1.000 39.15844  ? 419 ASN A HB2  1 
ATOM   6242 H  HB3  . ASN A 1 427 ? 20.49983  -15.90812 23.12871  1.000 39.15844  ? 419 ASN A HB3  1 
ATOM   6243 H  HD21 . ASN A 1 427 ? 21.56337  -17.85947 20.02892  1.000 43.30853  ? 419 ASN A HD21 1 
ATOM   6244 H  HD22 . ASN A 1 427 ? 21.74523  -16.38794 20.17145  1.000 43.30853  ? 419 ASN A HD22 1 
ATOM   6245 N  N    . TRP A 1 428 ? 17.94928  -13.10053 22.44426  1.000 27.49201  ? 420 TRP A N    1 
ATOM   6246 C  CA   . TRP A 1 428 ? 17.72067  -11.94688 23.30104  1.000 23.57959  ? 420 TRP A CA   1 
ATOM   6247 C  C    . TRP A 1 428 ? 16.76056  -12.29861 24.43393  1.000 21.58123  ? 420 TRP A C    1 
ATOM   6248 O  O    . TRP A 1 428 ? 15.80011  -13.04869 24.24550  1.000 27.85390  ? 420 TRP A O    1 
ATOM   6249 C  CB   . TRP A 1 428 ? 17.16665  -10.77330 22.48832  1.000 27.92122  ? 420 TRP A CB   1 
ATOM   6250 C  CG   . TRP A 1 428 ? 17.22215  -9.47431  23.23089  1.000 23.69328  ? 420 TRP A CG   1 
ATOM   6251 C  CD1  . TRP A 1 428 ? 18.21625  -8.54325  23.17831  1.000 22.87650  ? 420 TRP A CD1  1 
ATOM   6252 C  CD2  . TRP A 1 428 ? 16.24707  -8.96637  24.14864  1.000 22.64465  ? 420 TRP A CD2  1 
ATOM   6253 N  NE1  . TRP A 1 428 ? 17.92193  -7.48594  24.00274  1.000 20.23853  ? 420 TRP A NE1  1 
ATOM   6254 C  CE2  . TRP A 1 428 ? 16.72048  -7.72164  24.61449  1.000 23.80023  ? 420 TRP A CE2  1 
ATOM   6255 C  CE3  . TRP A 1 428 ? 15.02655  -9.44414  24.62675  1.000 25.71789  ? 420 TRP A CE3  1 
ATOM   6256 C  CZ2  . TRP A 1 428 ? 16.01169  -6.94222  25.52448  1.000 25.17491  ? 420 TRP A CZ2  1 
ATOM   6257 C  CZ3  . TRP A 1 428 ? 14.32898  -8.67442  25.54366  1.000 27.17102  ? 420 TRP A CZ3  1 
ATOM   6258 C  CH2  . TRP A 1 428 ? 14.82233  -7.43322  25.97797  1.000 31.81935  ? 420 TRP A CH2  1 
ATOM   6259 H  H    . TRP A 1 428 ? 17.58854  -13.04970 21.66523  1.000 32.96723  ? 420 TRP A H    1 
ATOM   6260 H  HA   . TRP A 1 428 ? 18.56428  -11.67015 23.69174  1.000 28.27231  ? 420 TRP A HA   1 
ATOM   6261 H  HB2  . TRP A 1 428 ? 17.68898  -10.67723 21.67663  1.000 33.48227  ? 420 TRP A HB2  1 
ATOM   6262 H  HB3  . TRP A 1 428 ? 16.23947  -10.95274 22.26690  1.000 33.48227  ? 420 TRP A HB3  1 
ATOM   6263 H  HD1  . TRP A 1 428 ? 18.98402  -8.61418  22.65831  1.000 27.42861  ? 420 TRP A HD1  1 
ATOM   6264 H  HE1  . TRP A 1 428 ? 18.41260  -6.78886  24.11638  1.000 24.26305  ? 420 TRP A HE1  1 
ATOM   6265 H  HE3  . TRP A 1 428 ? 14.68888  -10.26066 24.33662  1.000 30.83828  ? 420 TRP A HE3  1 
ATOM   6266 H  HZ2  . TRP A 1 428 ? 16.33610  -6.11940  25.81191  1.000 30.18670  ? 420 TRP A HZ2  1 
ATOM   6267 H  HZ3  . TRP A 1 428 ? 13.51877  -8.98554  25.87783  1.000 32.58204  ? 420 TRP A HZ3  1 
ATOM   6268 H  HH2  . TRP A 1 428 ? 14.32750  -6.93523  26.58793  1.000 38.16003  ? 420 TRP A HH2  1 
ATOM   6269 N  N    . ASP A 1 429 ? 17.01329  -11.72357 25.60942  1.000 26.73984  ? 421 ASP A N    1 
ATOM   6270 C  CA   . ASP A 1 429 ? 16.14777  -11.86700 26.77144  1.000 33.84053  ? 421 ASP A CA   1 
ATOM   6271 C  C    . ASP A 1 429 ? 16.36340  -10.64969 27.65837  1.000 24.20805  ? 421 ASP A C    1 
ATOM   6272 O  O    . ASP A 1 429 ? 17.34842  -9.92360  27.51000  1.000 29.29477  ? 421 ASP A O    1 
ATOM   6273 C  CB   . ASP A 1 429 ? 16.43871  -13.16464 27.53390  1.000 31.44547  ? 421 ASP A CB   1 
ATOM   6274 C  CG   . ASP A 1 429 ? 15.29094  -13.58015 28.44023  1.000 38.25868  ? 421 ASP A CG   1 
ATOM   6275 O  OD1  . ASP A 1 429 ? 14.20544  -12.95864 28.36178  1.000 34.53439  ? 421 ASP A OD1  1 
ATOM   6276 O  OD2  . ASP A 1 429 ? 15.47546  -14.52499 29.24026  1.000 30.77434  ? 421 ASP A OD2  1 
ATOM   6277 H  H    . ASP A 1 429 ? 17.70164  -11.23084 25.76108  1.000 32.06462  ? 421 ASP A H    1 
ATOM   6278 H  HA   . ASP A 1 429 ? 15.21701  -11.89392 26.49969  1.000 40.58545  ? 421 ASP A HA   1 
ATOM   6279 H  HB2  . ASP A 1 429 ? 16.59176  -13.87918 26.89601  1.000 37.71137  ? 421 ASP A HB2  1 
ATOM   6280 H  HB3  . ASP A 1 429 ? 17.22649  -13.03795 28.08550  1.000 37.71137  ? 421 ASP A HB3  1 
ATOM   6281 N  N    . TRP A 1 430 ? 15.43504  -10.42629 28.57863  1.000 27.90532  ? 422 TRP A N    1 
ATOM   6282 C  CA   . TRP A 1 430 ? 15.54031  -9.27758  29.46348  1.000 29.86460  ? 422 TRP A CA   1 
ATOM   6283 C  C    . TRP A 1 430 ? 16.90538  -9.27579  30.14809  1.000 34.28033  ? 422 TRP A C    1 
ATOM   6284 O  O    . TRP A 1 430 ? 17.34099  -10.32170 30.65014  1.000 41.09607  ? 422 TRP A O    1 
ATOM   6285 C  CB   . TRP A 1 430 ? 14.43521  -9.31108  30.52222  1.000 34.50176  ? 422 TRP A CB   1 
ATOM   6286 C  CG   . TRP A 1 430 ? 13.04001  -9.22965  29.99164  1.000 25.18940  ? 422 TRP A CG   1 
ATOM   6287 C  CD1  . TRP A 1 430 ? 12.11853  -10.23436 29.94203  1.000 27.45004  ? 422 TRP A CD1  1 
ATOM   6288 C  CD2  . TRP A 1 430 ? 12.39564  -8.06813  29.45135  1.000 16.96821  ? 422 TRP A CD2  1 
ATOM   6289 N  NE1  . TRP A 1 430 ? 10.94276  -9.77074  29.39003  1.000 23.65886  ? 422 TRP A NE1  1 
ATOM   6290 C  CE2  . TRP A 1 430 ? 11.08635  -8.44269  29.09219  1.000 18.83008  ? 422 TRP A CE2  1 
ATOM   6291 C  CE3  . TRP A 1 430 ? 12.80005  -6.75038  29.23668  1.000 17.44846  ? 422 TRP A CE3  1 
ATOM   6292 C  CZ2  . TRP A 1 430 ? 10.18495  -7.55381  28.51741  1.000 18.47172  ? 422 TRP A CZ2  1 
ATOM   6293 C  CZ3  . TRP A 1 430 ? 11.89211  -5.86214  28.67278  1.000 22.88635  ? 422 TRP A CZ3  1 
ATOM   6294 C  CH2  . TRP A 1 430 ? 10.60212  -6.27189  28.31930  1.000 17.51761  ? 422 TRP A CH2  1 
ATOM   6295 H  H    . TRP A 1 430 ? 14.74253  -10.91916 28.70942  1.000 33.46320  ? 422 TRP A H    1 
ATOM   6296 H  HA   . TRP A 1 430 ? 15.44259  -8.46365  28.94495  1.000 35.81434  ? 422 TRP A HA   1 
ATOM   6297 H  HB2  . TRP A 1 430 ? 14.50917  -10.14297 31.01555  1.000 41.37892  ? 422 TRP A HB2  1 
ATOM   6298 H  HB3  . TRP A 1 430 ? 14.56173  -8.55816  31.12056  1.000 41.37892  ? 422 TRP A HB3  1 
ATOM   6299 H  HD1  . TRP A 1 430 ? 12.26216  -11.10449 30.23722  1.000 32.91686  ? 422 TRP A HD1  1 
ATOM   6300 H  HE1  . TRP A 1 430 ? 10.23469  -10.23978 29.25497  1.000 28.36744  ? 422 TRP A HE1  1 
ATOM   6301 H  HE3  . TRP A 1 430 ? 13.65757  -6.47268  29.46567  1.000 20.91496  ? 422 TRP A HE3  1 
ATOM   6302 H  HZ2  . TRP A 1 430 ? 9.32831   -7.82437  28.27687  1.000 22.14287  ? 422 TRP A HZ2  1 
ATOM   6303 H  HZ3  . TRP A 1 430 ? 12.14668  -4.97949  28.52781  1.000 27.44043  ? 422 TRP A HZ3  1 
ATOM   6304 H  HH2  . TRP A 1 430 ? 10.01673  -5.65617  27.94100  1.000 20.99794  ? 422 TRP A HH2  1 
ATOM   6305 N  N    . PRO A 1 431 ? 17.60489  -8.14966  30.19841  1.000 38.36239  ? 423 PRO A N    1 
ATOM   6306 C  CA   . PRO A 1 431 ? 18.87448  -8.08635  30.93274  1.000 41.11525  ? 423 PRO A CA   1 
ATOM   6307 C  C    . PRO A 1 431 ? 18.63558  -8.00064  32.44026  1.000 51.56833  ? 423 PRO A C    1 
ATOM   6308 O  O    . PRO A 1 431 ? 17.50175  -7.91360  32.92047  1.000 56.31527  ? 423 PRO A O    1 
ATOM   6309 C  CB   . PRO A 1 431 ? 19.53756  -6.81545  30.39281  1.000 44.27538  ? 423 PRO A CB   1 
ATOM   6310 C  CG   . PRO A 1 431 ? 18.37990  -5.92963  30.00952  1.000 38.00536  ? 423 PRO A CG   1 
ATOM   6311 C  CD   . PRO A 1 431 ? 17.27857  -6.87812  29.52199  1.000 33.02852  ? 423 PRO A CD   1 
ATOM   6312 H  HA   . PRO A 1 431 ? 19.42846  -8.85666  30.73117  1.000 49.31511  ? 423 PRO A HA   1 
ATOM   6313 H  HB2  . PRO A 1 431 ? 20.08024  -6.40333  31.08314  1.000 53.10726  ? 423 PRO A HB2  1 
ATOM   6314 H  HB3  . PRO A 1 431 ? 20.08651  -7.02749  29.62170  1.000 53.10726  ? 423 PRO A HB3  1 
ATOM   6315 H  HG2  . PRO A 1 431 ? 18.08258  -5.42520  30.78286  1.000 45.58324  ? 423 PRO A HG2  1 
ATOM   6316 H  HG3  . PRO A 1 431 ? 18.65056  -5.32360  29.30216  1.000 45.58324  ? 423 PRO A HG3  1 
ATOM   6317 H  HD2  . PRO A 1 431 ? 16.40313  -6.55840  29.79083  1.000 39.61104  ? 423 PRO A HD2  1 
ATOM   6318 H  HD3  . PRO A 1 431 ? 17.31264  -6.98080  28.55804  1.000 39.61104  ? 423 PRO A HD3  1 
ATOM   6319 N  N    . GLN A 1 432 ? 19.73674  -8.03573  33.18770  1.000 61.16845  ? 424 GLN A N    1 
ATOM   6320 C  CA   . GLN A 1 432 ? 19.70246  -7.83953  34.63522  1.000 67.20646  ? 424 GLN A CA   1 
ATOM   6321 C  C    . GLN A 1 432 ? 20.67370  -6.71944  35.01959  1.000 64.18237  ? 424 GLN A C    1 
ATOM   6322 O  O    . GLN A 1 432 ? 20.91784  -5.78255  34.24882  1.000 64.56660  ? 424 GLN A O    1 
ATOM   6323 C  CB   . GLN A 1 432 ? 20.04966  -9.12794  35.37495  1.000 58.34928  ? 424 GLN A CB   1 
ATOM   6324 C  CG   . GLN A 1 432 ? 18.91135  -10.13057 35.41536  1.000 57.07359  ? 424 GLN A CG   1 
ATOM   6325 C  CD   . GLN A 1 432 ? 18.81158  -10.93986 34.13813  1.000 56.65721  ? 424 GLN A CD   1 
ATOM   6326 O  OE1  . GLN A 1 432 ? 17.77857  -10.94106 33.46634  1.000 55.78514  ? 424 GLN A OE1  1 
ATOM   6327 N  NE2  . GLN A 1 432 ? 19.89497  -11.63074 33.79102  1.000 58.50964  ? 424 GLN A NE2  1 
ATOM   6328 O  OXT  . GLN A 1 432 ? 21.25567  -6.72481  36.10391  1.000 53.86655  ? 424 GLN A OXT  1 
ATOM   6329 H  H    . GLN A 1 432 ? 20.52652  -8.17331  32.87637  1.000 73.37895  ? 424 GLN A H    1 
ATOM   6330 H  HA   . GLN A 1 432 ? 18.80646  -7.59195  34.91232  1.000 80.62457  ? 424 GLN A HA   1 
ATOM   6331 H  HB2  . GLN A 1 432 ? 20.80159  -9.55024  34.93092  1.000 69.99595  ? 424 GLN A HB2  1 
ATOM   6332 H  HB3  . GLN A 1 432 ? 20.28507  -8.90904  36.29014  1.000 69.99595  ? 424 GLN A HB3  1 
ATOM   6333 H  HG2  . GLN A 1 432 ? 19.05540  -10.74536 36.15169  1.000 68.46512  ? 424 GLN A HG2  1 
ATOM   6334 H  HG3  . GLN A 1 432 ? 18.07424  -9.65616  35.53818  1.000 68.46512  ? 424 GLN A HG3  1 
ATOM   6335 H  HE21 . GLN A 1 432 ? 20.59962  -11.60143 34.28316  1.000 70.18838  ? 424 GLN A HE21 1 
ATOM   6336 H  HE22 . GLN A 1 432 ? 19.89033  -12.10646 33.07459  1.000 70.18838  ? 424 GLN A HE22 1 
HETATM 6337 C  C1   . GOL B 2 .   ? 18.85676  9.56903   25.20059  1.000 27.83593  ? 501 GOL A C1   1 
HETATM 6338 O  O1   . GOL B 2 .   ? 20.25162  9.70571   25.10348  1.000 48.01330  ? 501 GOL A O1   1 
HETATM 6339 C  C2   . GOL B 2 .   ? 18.52803  8.08730   25.15893  1.000 40.22000  ? 501 GOL A C2   1 
HETATM 6340 O  O2   . GOL B 2 .   ? 17.14375  7.87682   25.06403  1.000 38.07603  ? 501 GOL A O2   1 
HETATM 6341 C  C3   . GOL B 2 .   ? 19.27845  7.55346   23.94508  1.000 46.88039  ? 501 GOL A C3   1 
HETATM 6342 O  O3   . GOL B 2 .   ? 20.00540  6.42041   24.41563  1.000 37.95662  ? 501 GOL A O3   1 
HETATM 6343 H  H11  . GOL B 2 .   ? 18.38990  10.01720  24.47804  1.000 33.37993  ? 501 GOL A H11  1 
HETATM 6344 H  H12  . GOL B 2 .   ? 18.50403  9.94851   26.02064  1.000 33.37993  ? 501 GOL A H12  1 
HETATM 6345 H  HO1  . GOL B 2 .   ? 20.40911  10.51915  24.91192  1.000 57.59277  ? 501 GOL A HO1  1 
HETATM 6346 H  H2   . GOL B 2 .   ? 18.82101  7.64027   25.96839  1.000 48.24081  ? 501 GOL A H2   1 
HETATM 6347 H  HO2  . GOL B 2 .   ? 16.92545  7.88532   24.23169  1.000 45.66805  ? 501 GOL A HO2  1 
HETATM 6348 H  H31  . GOL B 2 .   ? 19.84199  8.25456   23.58206  1.000 56.23328  ? 501 GOL A H31  1 
HETATM 6349 H  H32  . GOL B 2 .   ? 18.64404  7.34460   23.24166  1.000 56.23328  ? 501 GOL A H32  1 
HETATM 6350 H  HO3  . GOL B 2 .   ? 20.32788  6.02884   23.73881  1.000 45.52475  ? 501 GOL A HO3  1 
HETATM 6351 CL CL   . CL  C 3 .   ? -8.23610  6.32732   25.14624  1.000 55.66023  ? 502 CL  A CL   1 
HETATM 6352 O  O    . HOH D 4 .   ? 10.65916  -14.41860 10.91549  1.000 36.10016  ? 601 HOH A O    1 
HETATM 6353 O  O    . HOH D 4 .   ? -4.14645  -9.64611  -9.60032  1.000 39.42777  ? 602 HOH A O    1 
HETATM 6354 O  O    . HOH D 4 .   ? 18.79662  -8.93139  -7.00390  1.000 23.51389  ? 603 HOH A O    1 
HETATM 6355 O  O    . HOH D 4 .   ? 14.42573  12.81129  7.50022   1.000 29.84770  ? 604 HOH A O    1 
HETATM 6356 O  O    . HOH D 4 .   ? -8.26331  12.53354  19.81023  1.000 21.89895  ? 605 HOH A O    1 
HETATM 6357 O  O    . HOH D 4 .   ? 7.87372   -13.70336 21.69081  1.000 33.32326  ? 606 HOH A O    1 
HETATM 6358 O  O    . HOH D 4 .   ? 21.22994  9.65882   -17.20450 1.000 38.37298  ? 607 HOH A O    1 
HETATM 6359 O  O    . HOH D 4 .   ? 6.704     -11.270   33.273    1.000 22.35149  ? 608 HOH A O    1 
HETATM 6360 O  O    . HOH D 4 .   ? 8.87778   -13.95294 -15.21643 1.000 15.92938  ? 609 HOH A O    1 
HETATM 6361 O  O    . HOH D 4 .   ? 1.74372   -12.25589 -4.60786  1.000 42.43424  ? 610 HOH A O    1 
HETATM 6362 O  O    . HOH D 4 .   ? -1.19855  -12.55792 23.53862  1.000 15.00051  ? 611 HOH A O    1 
HETATM 6363 O  O    . HOH D 4 .   ? 21.10521  -1.53171  19.29763  1.000 26.43344  ? 612 HOH A O    1 
HETATM 6364 O  O    . HOH D 4 .   ? 8.64090   -16.36397 -8.19429  1.000 24.87485  ? 613 HOH A O    1 
HETATM 6365 O  O    . HOH D 4 .   ? -2.53482  -2.58672  32.53774  1.000 27.26737  ? 614 HOH A O    1 
HETATM 6366 O  O    . HOH D 4 .   ? -7.69519  -3.08723  13.50358  1.000 33.25609  ? 615 HOH A O    1 
HETATM 6367 O  O    . HOH D 4 .   ? 1.97985   -4.40288  11.40916  1.000 19.97603  ? 616 HOH A O    1 
HETATM 6368 O  O    . HOH D 4 .   ? -0.88334  -1.82201  -1.47942  1.000 31.56823  ? 617 HOH A O    1 
HETATM 6369 O  O    . HOH D 4 .   ? -1.27823  12.30494  16.50803  1.000 14.80150  ? 618 HOH A O    1 
HETATM 6370 O  O    . HOH D 4 .   ? -10.98054 14.15386  25.34286  1.000 31.73862  ? 619 HOH A O    1 
HETATM 6371 O  O    . HOH D 4 .   ? 12.15837  -19.09078 -19.22293 1.000 28.33456  ? 620 HOH A O    1 
HETATM 6372 O  O    . HOH D 4 .   ? 7.53538   10.64351  -2.47675  1.000 23.63452  ? 621 HOH A O    1 
HETATM 6373 O  O    . HOH D 4 .   ? -1.08459  -11.33851 14.95120  1.000 17.18515  ? 622 HOH A O    1 
HETATM 6374 O  O    . HOH D 4 .   ? 12.77874  8.70817   8.91106   1.000 17.02530  ? 623 HOH A O    1 
HETATM 6375 O  O    . HOH D 4 .   ? 6.16480   20.31069  17.02379  1.000 24.10057  ? 624 HOH A O    1 
HETATM 6376 O  O    . HOH D 4 .   ? 5.85404   1.02164   -23.03271 1.000 27.11917  ? 625 HOH A O    1 
HETATM 6377 O  O    . HOH D 4 .   ? 29.54206  -3.08782  -29.93970 1.000 48.84938  ? 626 HOH A O    1 
HETATM 6378 O  O    . HOH D 4 .   ? 9.906     15.187    30.416    1.000 30.81804  ? 627 HOH A O    1 
HETATM 6379 O  O    . HOH D 4 .   ? -9.18888  -7.09311  23.34294  1.000 24.56056  ? 628 HOH A O    1 
HETATM 6380 O  O    . HOH D 4 .   ? 6.56879   -9.71736  26.70871  1.000 20.51264  ? 629 HOH A O    1 
HETATM 6381 O  O    . HOH D 4 .   ? 20.268    19.902    -10.097   1.000 39.84678  ? 630 HOH A O    1 
HETATM 6382 O  O    . HOH D 4 .   ? 18.66430  -16.70744 12.50035  1.000 38.66583  ? 631 HOH A O    1 
HETATM 6383 O  O    . HOH D 4 .   ? 15.80272  -1.07032  -26.65009 1.000 27.87652  ? 632 HOH A O    1 
HETATM 6384 O  O    . HOH D 4 .   ? -0.26128  3.65996   6.58210   1.000 21.45174  ? 633 HOH A O    1 
HETATM 6385 O  O    . HOH D 4 .   ? 5.35721   -13.80795 21.23321  1.000 34.05466  ? 634 HOH A O    1 
HETATM 6386 O  O    . HOH D 4 .   ? 8.26593   -7.36892  -20.43275 1.000 30.24312  ? 635 HOH A O    1 
HETATM 6387 O  O    . HOH D 4 .   ? -12.34246 -13.29463 24.21338  1.000 52.03761  ? 636 HOH A O    1 
HETATM 6388 O  O    . HOH D 4 .   ? 21.18079  -17.73251 -15.74928 1.000 34.77680  ? 637 HOH A O    1 
HETATM 6389 O  O    . HOH D 4 .   ? -7.23531  18.14025  24.12561  1.000 22.75388  ? 638 HOH A O    1 
HETATM 6390 O  O    . HOH D 4 .   ? 33.82206  9.76327   -11.92258 1.000 37.93353  ? 639 HOH A O    1 
HETATM 6391 O  O    . HOH D 4 .   ? -3.72630  -3.44739  11.76118  1.000 30.71378  ? 640 HOH A O    1 
HETATM 6392 O  O    . HOH D 4 .   ? 13.53698  -15.20168 -7.25074  1.000 22.60871  ? 641 HOH A O    1 
HETATM 6393 O  O    . HOH D 4 .   ? -1.87232  0.15503   -15.93425 1.000 32.40904  ? 642 HOH A O    1 
HETATM 6394 O  O    . HOH D 4 .   ? 23.66980  10.19895  -11.98328 1.000 33.04625  ? 643 HOH A O    1 
HETATM 6395 O  O    . HOH D 4 .   ? -8.546    25.293    28.279    1.000 17.71365  ? 644 HOH A O    1 
HETATM 6396 O  O    . HOH D 4 .   ? 24.22557  -1.70612  11.11980  1.000 28.72898  ? 645 HOH A O    1 
HETATM 6397 O  O    . HOH D 4 .   ? 7.11043   0.49499   -27.84671 1.000 20.76219  ? 646 HOH A O    1 
HETATM 6398 O  O    . HOH D 4 .   ? 14.292    4.310     37.066    1.000 38.72201  ? 647 HOH A O    1 
HETATM 6399 O  O    . HOH D 4 .   ? 15.53639  -7.37869  -24.14751 1.000 31.80217  ? 648 HOH A O    1 
HETATM 6400 O  O    . HOH D 4 .   ? 7.98852   -7.30580  13.40474  1.000 18.57324  ? 649 HOH A O    1 
HETATM 6401 O  O    . HOH D 4 .   ? 22.71666  -0.59716  -1.39906  1.000 22.26371  ? 650 HOH A O    1 
HETATM 6402 O  O    . HOH D 4 .   ? 7.44209   11.67228  5.62269   1.000 33.19026  ? 651 HOH A O    1 
HETATM 6403 O  O    . HOH D 4 .   ? -5.97511  12.86808  37.76073  1.000 24.96539  ? 652 HOH A O    1 
HETATM 6404 O  O    . HOH D 4 .   ? 4.33246   -0.67693  -21.70156 1.000 27.09632  ? 653 HOH A O    1 
HETATM 6405 O  O    . HOH D 4 .   ? 26.94551  -1.66805  -11.38642 1.000 28.55606  ? 654 HOH A O    1 
HETATM 6406 O  O    . HOH D 4 .   ? -4.43536  1.05851   20.23867  1.000 15.71870  ? 655 HOH A O    1 
HETATM 6407 O  O    . HOH D 4 .   ? 18.58552  5.36666   20.52399  1.000 33.76469  ? 656 HOH A O    1 
HETATM 6408 O  O    . HOH D 4 .   ? 21.15527  1.29680   16.40349  1.000 27.11915  ? 657 HOH A O    1 
HETATM 6409 O  O    . HOH D 4 .   ? 13.97650  15.39227  30.59502  1.000 41.49161  ? 658 HOH A O    1 
HETATM 6410 O  O    . HOH D 4 .   ? 4.35945   -2.16364  13.08171  1.000 16.60332  ? 659 HOH A O    1 
HETATM 6411 O  O    . HOH D 4 .   ? -14.90004 16.15458  30.41519  1.000 42.47044  ? 660 HOH A O    1 
HETATM 6412 O  O    . HOH D 4 .   ? 28.74946  -3.56662  -16.83152 1.000 27.90141  ? 661 HOH A O    1 
HETATM 6413 O  O    . HOH D 4 .   ? 8.72606   -11.05196 -13.66637 1.000 22.24719  ? 662 HOH A O    1 
HETATM 6414 O  O    . HOH D 4 .   ? 2.02693   5.79362   -1.30926  1.000 40.02353  ? 663 HOH A O    1 
HETATM 6415 O  O    . HOH D 4 .   ? -4.85689  -4.83572  33.93818  1.000 30.57319  ? 664 HOH A O    1 
HETATM 6416 O  O    . HOH D 4 .   ? -4.85204  -1.38138  8.42620   1.000 27.94135  ? 665 HOH A O    1 
HETATM 6417 O  O    . HOH D 4 .   ? 5.69119   8.19824   3.91589   1.000 29.74931  ? 666 HOH A O    1 
HETATM 6418 O  O    . HOH D 4 .   ? -4.06721  14.67825  9.16388   1.000 37.93607  ? 667 HOH A O    1 
HETATM 6419 O  O    . HOH D 4 .   ? 11.12693  6.06902   31.26125  1.000 19.30154  ? 668 HOH A O    1 
HETATM 6420 O  O    . HOH D 4 .   ? 8.92088   10.93482  9.75518   1.000 19.43061  ? 669 HOH A O    1 
HETATM 6421 O  O    . HOH D 4 .   ? -6.89299  18.97376  34.00210  1.000 33.35664  ? 670 HOH A O    1 
HETATM 6422 O  O    . HOH D 4 .   ? 7.26190   -11.65182 5.47309   1.000 14.16239  ? 671 HOH A O    1 
HETATM 6423 O  O    . HOH D 4 .   ? -8.02450  11.55150  37.46239  1.000 21.64860  ? 672 HOH A O    1 
HETATM 6424 O  O    . HOH D 4 .   ? 14.98701  10.62484  26.45185  1.000 22.46713  ? 673 HOH A O    1 
HETATM 6425 O  O    . HOH D 4 .   ? 17.88082  6.18317   -16.21071 1.000 26.20337  ? 674 HOH A O    1 
HETATM 6426 O  O    . HOH D 4 .   ? -3.00798  -2.02310  13.82606  1.000 24.77009  ? 675 HOH A O    1 
HETATM 6427 O  O    . HOH D 4 .   ? 9.07570   -5.78345  -7.81994  1.000 27.88361  ? 676 HOH A O    1 
HETATM 6428 O  O    . HOH D 4 .   ? 9.34191   2.39714   34.62896  1.000 16.51172  ? 677 HOH A O    1 
HETATM 6429 O  O    . HOH D 4 .   ? 14.61523  -5.26225  -20.91570 1.000 15.93398  ? 678 HOH A O    1 
HETATM 6430 O  O    . HOH D 4 .   ? 20.35782  5.80428   -14.92940 1.000 31.55764  ? 679 HOH A O    1 
HETATM 6431 O  O    . HOH D 4 .   ? 17.09815  -1.52581  -29.25113 1.000 29.14157  ? 680 HOH A O    1 
HETATM 6432 O  O    . HOH D 4 .   ? -2.03702  -8.81203  38.34501  1.000 21.27528  ? 681 HOH A O    1 
HETATM 6433 O  O    . HOH D 4 .   ? 15.46231  -16.00135 -9.82131  1.000 23.73813  ? 682 HOH A O    1 
HETATM 6434 O  O    . HOH D 4 .   ? 16.44083  9.47716   15.40151  1.000 27.19814  ? 683 HOH A O    1 
HETATM 6435 O  O    . HOH D 4 .   ? 25.17189  -6.05687  -6.75307  1.000 23.75481  ? 684 HOH A O    1 
HETATM 6436 O  O    . HOH D 4 .   ? -3.09357  -6.25356  20.74230  1.000 18.37798  ? 685 HOH A O    1 
HETATM 6437 O  O    . HOH D 4 .   ? 22.54848  9.93017   4.06685   1.000 37.16579  ? 686 HOH A O    1 
HETATM 6438 O  O    . HOH D 4 .   ? 19.96472  5.90572   -5.88084  1.000 17.58606  ? 687 HOH A O    1 
HETATM 6439 O  O    . HOH D 4 .   ? 7.62292   -9.78213  11.76773  1.000 21.64325  ? 688 HOH A O    1 
HETATM 6440 O  O    . HOH D 4 .   ? -4.79825  5.59750   23.84773  1.000 24.50399  ? 689 HOH A O    1 
HETATM 6441 O  O    . HOH D 4 .   ? 16.79643  -13.54438 -2.84167  1.000 37.17832  ? 690 HOH A O    1 
HETATM 6442 O  O    . HOH D 4 .   ? 6.35112   -10.37563 17.40799  1.000 14.78915  ? 691 HOH A O    1 
HETATM 6443 O  O    . HOH D 4 .   ? -11.893   16.799    21.317    1.000 28.67939  ? 692 HOH A O    1 
HETATM 6444 O  O    . HOH D 4 .   ? 15.19573  11.37746  3.77496   1.000 20.16411  ? 693 HOH A O    1 
HETATM 6445 O  O    . HOH D 4 .   ? 8.10645   2.51951   -21.72280 1.000 22.59691  ? 694 HOH A O    1 
HETATM 6446 O  O    . HOH D 4 .   ? 9.10677   8.33764   31.23638  1.000 20.90727  ? 695 HOH A O    1 
HETATM 6447 O  O    . HOH D 4 .   ? 21.25708  -0.20964  -29.08210 1.000 37.86341  ? 696 HOH A O    1 
HETATM 6448 O  O    . HOH D 4 .   ? 15.97388  1.65073   -25.47873 1.000 31.07493  ? 697 HOH A O    1 
HETATM 6449 O  O    . HOH D 4 .   ? 21.50397  3.75954   -13.65094 1.000 23.85777  ? 698 HOH A O    1 
HETATM 6450 O  O    . HOH D 4 .   ? 8.47880   -0.17859  35.31721  1.000 19.30502  ? 699 HOH A O    1 
HETATM 6451 O  O    . HOH D 4 .   ? 5.11789   -13.22166 3.06355   1.000 18.86076  ? 700 HOH A O    1 
HETATM 6452 O  O    . HOH D 4 .   ? 5.12934   -9.80730  12.37669  1.000 18.46357  ? 701 HOH A O    1 
HETATM 6453 O  O    . HOH D 4 .   ? -4.92077  3.36271   -11.37207 1.000 32.64659  ? 702 HOH A O    1 
HETATM 6454 O  O    . HOH D 4 .   ? 15.93912  16.58039  20.75682  1.000 34.67351  ? 703 HOH A O    1 
HETATM 6455 O  O    . HOH D 4 .   ? 11.49617  16.56164  13.39362  1.000 25.76956  ? 704 HOH A O    1 
HETATM 6456 O  O    . HOH D 4 .   ? -0.42062  -14.88425 34.73897  1.000 14.13974  ? 705 HOH A O    1 
HETATM 6457 O  O    . HOH D 4 .   ? -2.59926  15.49087  30.23986  1.000 22.59913  ? 706 HOH A O    1 
HETATM 6458 O  O    . HOH D 4 .   ? 6.69397   2.91622   35.59263  1.000 19.95556  ? 707 HOH A O    1 
HETATM 6459 O  O    . HOH D 4 .   ? 9.70174   4.23534   32.46932  1.000 20.10069  ? 708 HOH A O    1 
HETATM 6460 O  O    . HOH D 4 .   ? 0.87281   -2.61925  2.66052   1.000 32.01908  ? 709 HOH A O    1 
HETATM 6461 O  O    . HOH D 4 .   ? 12.47380  13.52164  9.62292   1.000 35.88296  ? 710 HOH A O    1 
HETATM 6462 O  O    . HOH D 4 .   ? 18.92580  -9.79977  -9.82818  1.000 28.88901  ? 711 HOH A O    1 
HETATM 6463 O  O    . HOH D 4 .   ? 30.09329  -12.04125 6.60427   1.000 41.15403  ? 712 HOH A O    1 
HETATM 6464 O  O    . HOH D 4 .   ? 15.43616  10.94755  29.98825  1.000 44.40184  ? 713 HOH A O    1 
HETATM 6465 O  O    . HOH D 4 .   ? 1.03371   -1.48345  0.46495   1.000 29.99572  ? 714 HOH A O    1 
HETATM 6466 O  O    . HOH D 4 .   ? -7.95544  -3.52929  -12.64213 1.000 38.29116  ? 715 HOH A O    1 
HETATM 6467 O  O    . HOH D 4 .   ? -6.18932  4.06288   22.79357  1.000 29.21706  ? 716 HOH A O    1 
HETATM 6468 O  O    . HOH D 4 .   ? 2.45158   -1.77027  10.83289  1.000 25.39215  ? 717 HOH A O    1 
HETATM 6469 O  O    . HOH D 4 .   ? 6.64793   -12.72954 9.62458   1.000 28.01863  ? 718 HOH A O    1 
HETATM 6470 O  O    . HOH D 4 .   ? 11.90740  -10.86773 -5.34981  1.000 25.15085  ? 719 HOH A O    1 
HETATM 6471 O  O    . HOH D 4 .   ? 26.30171  -7.22196  -7.93317  1.000 23.58342  ? 720 HOH A O    1 
HETATM 6472 O  O    . HOH D 4 .   ? 23.11413  -4.49102  -6.78460  1.000 15.60459  ? 721 HOH A O    1 
HETATM 6473 O  O    . HOH D 4 .   ? 24.78118  4.93262   10.27482  1.000 22.57841  ? 722 HOH A O    1 
HETATM 6474 O  O    . HOH D 4 .   ? -7.94148  -5.47281  12.65246  1.000 38.31303  ? 723 HOH A O    1 
HETATM 6475 O  O    . HOH D 4 .   ? 37.84593  -0.59189  -1.50392  1.000 37.91446  ? 724 HOH A O    1 
HETATM 6476 O  O    . HOH D 4 .   ? 13.60003  -16.85116 -20.18213 1.000 32.24054  ? 725 HOH A O    1 
HETATM 6477 O  O    . HOH D 4 .   ? 11.071    17.433    28.311    1.000 43.84133  ? 726 HOH A O    1 
HETATM 6478 O  O    . HOH D 4 .   ? -10.41958 18.50716  32.85122  1.000 33.76908  ? 727 HOH A O    1 
HETATM 6479 O  O    . HOH D 4 .   ? 2.97495   -11.73209 15.49506  1.000 24.70622  ? 728 HOH A O    1 
HETATM 6480 O  O    . HOH D 4 .   ? -9.15131  -11.54413 20.41328  1.000 43.52301  ? 729 HOH A O    1 
HETATM 6481 O  O    . HOH D 4 .   ? 9.61370   16.99514  11.46699  1.000 27.94121  ? 730 HOH A O    1 
HETATM 6482 O  O    . HOH D 4 .   ? 26.80683  -3.18768  10.48280  1.000 35.32339  ? 731 HOH A O    1 
HETATM 6483 O  O    . HOH D 4 .   ? 0.02811   11.47751  -4.86645  1.000 40.00211  ? 732 HOH A O    1 
HETATM 6484 O  O    . HOH D 4 .   ? 6.97700   13.31097  -3.28032  1.000 32.68310  ? 733 HOH A O    1 
HETATM 6485 O  O    . HOH D 4 .   ? -2.24366  -13.62471 13.58998  1.000 23.15345  ? 734 HOH A O    1 
HETATM 6486 O  O    . HOH D 4 .   ? 23.71242  -9.06211  -10.27461 1.000 27.54393  ? 735 HOH A O    1 
HETATM 6487 O  O    . HOH D 4 .   ? 9.57272   -4.95011  36.27481  1.000 26.10100  ? 736 HOH A O    1 
HETATM 6488 O  O    . HOH D 4 .   ? 11.61337  -20.13620 2.64632   1.000 35.36521  ? 737 HOH A O    1 
HETATM 6489 O  O    . HOH D 4 .   ? 24.33110  -7.81596  -8.53435  1.000 33.87131  ? 738 HOH A O    1 
HETATM 6490 O  O    . HOH D 4 .   ? 15.83621  -15.66401 -2.69381  1.000 38.65801  ? 739 HOH A O    1 
HETATM 6491 O  O    . HOH D 4 .   ? 11.52594  11.19079  9.97259   1.000 33.63215  ? 740 HOH A O    1 
HETATM 6492 O  O    . HOH D 4 .   ? -5.59985  -5.13963  10.51224  1.000 26.57693  ? 741 HOH A O    1 
HETATM 6493 O  O    . HOH D 4 .   ? -6.190    22.691    19.632    1.000 31.15470  ? 742 HOH A O    1 
HETATM 6494 O  O    . HOH D 4 .   ? 6.04036   -16.02905 -8.95613  1.000 32.50423  ? 743 HOH A O    1 
HETATM 6495 O  O    . HOH D 4 .   ? -5.47989  -15.67757 7.41191   1.000 40.19727  ? 744 HOH A O    1 
HETATM 6496 O  O    . HOH D 4 .   ? 4.36790   -15.17338 5.34465   1.000 39.81883  ? 745 HOH A O    1 
HETATM 6497 O  O    . HOH D 4 .   ? 16.09552  -17.08878 -0.21415  1.000 45.50403  ? 746 HOH A O    1 
HETATM 6498 O  O    . HOH D 4 .   ? 10.76265  -20.59044 0.54855   1.000 41.26983  ? 747 HOH A O    1 
# 
