data_8ZQW
# 
_entry.id   8ZQW 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZQW         pdb_00008zqw 10.2210/pdb8zqw/pdb 
WWPDB D_1300048385 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZQW 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              hbluo@hainanu.edu.cn 
_pdbx_contact_author.name_first         Hai-Bin 
_pdbx_contact_author.name_last          Luo 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2163-0509 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Huang, Y.-Y.' 1 ? 
'Luo, H.-B.'   2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   CC 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Chin.Chem.Lett. 
_citation.journal_id_ASTM           CCLEE7 
_citation.journal_id_CSD            1182 
_citation.journal_id_ISSN           1001-8417 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                110586 
_citation.page_last                 ? 
_citation.title                     
'Structure-based optimization of isoaurostatin as novel PDE4 inhibitors with anti-fibrotic effects' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.cclet.2024.110586 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Huang, Y.Y.' 1  ? 
primary 'Luo, X.'     2  ? 
primary 'Zhang, K.'   3  ? 
primary 'Liang, Y.'   4  ? 
primary 'Zhang, F.'   5  ? 
primary 'Liao, G.'    6  ? 
primary 'Xie, S.'     7  ? 
primary 'Huang, P.L.' 8  ? 
primary 'Hou, S.'     9  ? 
primary 'Zhou, Q.'    10 ? 
primary 'Zou, Y.'     11 ? 
primary 'Luo, H.B.'   12 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 
;3',5'-cyclic-AMP phosphodiesterase 4D
;
57758.402 2   3.1.4.53 ? ? ? 
2 non-polymer syn 'ZINC ION'                                                                                                65.409 
2   ?        ? ? ? 
3 non-polymer syn 'MAGNESIUM ION'                                                                                           24.305 
2   ?        ? ? ? 
4 non-polymer syn '(3~{Z})-3-[[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]methylidene]-6-oxidanyl-1~{H}-indol-2-one' 
387.377   2   ?        ? ? ? 
5 water       nat water                                                                                                     18.015 
171 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'DPDE3,PDE43,cAMP-specific phosphodiesterase 4D' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIP
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL
LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLS
NPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE
QVEEEAVGEEEESQPEACVIDDRSPD
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIP
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL
LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLS
NPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE
QVEEEAVGEEEESQPEACVIDDRSPD
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                                                                                ZN    
3 'MAGNESIUM ION'                                                                                           MG    
4 '(3~{Z})-3-[[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]methylidene]-6-oxidanyl-1~{H}-indol-2-one' A1D8Q 
5 water                                                                                                     HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   SER n 
1 4   ASN n 
1 5   LYS n 
1 6   PHE n 
1 7   LYS n 
1 8   ARG n 
1 9   MET n 
1 10  LEU n 
1 11  ASN n 
1 12  ARG n 
1 13  GLU n 
1 14  LEU n 
1 15  THR n 
1 16  HIS n 
1 17  LEU n 
1 18  SER n 
1 19  GLU n 
1 20  MET n 
1 21  SER n 
1 22  ARG n 
1 23  SER n 
1 24  GLY n 
1 25  ASN n 
1 26  GLN n 
1 27  VAL n 
1 28  SER n 
1 29  GLU n 
1 30  PHE n 
1 31  ILE n 
1 32  SER n 
1 33  ASN n 
1 34  THR n 
1 35  PHE n 
1 36  LEU n 
1 37  ASP n 
1 38  LYS n 
1 39  GLN n 
1 40  HIS n 
1 41  GLU n 
1 42  VAL n 
1 43  GLU n 
1 44  ILE n 
1 45  PRO n 
1 46  SER n 
1 47  PRO n 
1 48  THR n 
1 49  GLN n 
1 50  LYS n 
1 51  GLU n 
1 52  LYS n 
1 53  GLU n 
1 54  LYS n 
1 55  LYS n 
1 56  LYS n 
1 57  ARG n 
1 58  PRO n 
1 59  MET n 
1 60  SER n 
1 61  GLN n 
1 62  ILE n 
1 63  SER n 
1 64  GLY n 
1 65  VAL n 
1 66  LYS n 
1 67  LYS n 
1 68  LEU n 
1 69  MET n 
1 70  HIS n 
1 71  SER n 
1 72  SER n 
1 73  SER n 
1 74  LEU n 
1 75  THR n 
1 76  ASN n 
1 77  SER n 
1 78  SER n 
1 79  ILE n 
1 80  PRO n 
1 81  ARG n 
1 82  PHE n 
1 83  GLY n 
1 84  VAL n 
1 85  LYS n 
1 86  THR n 
1 87  GLU n 
1 88  GLN n 
1 89  GLU n 
1 90  ASP n 
1 91  VAL n 
1 92  LEU n 
1 93  ALA n 
1 94  LYS n 
1 95  GLU n 
1 96  LEU n 
1 97  GLU n 
1 98  ASP n 
1 99  VAL n 
1 100 ASN n 
1 101 LYS n 
1 102 TRP n 
1 103 GLY n 
1 104 LEU n 
1 105 HIS n 
1 106 VAL n 
1 107 PHE n 
1 108 ARG n 
1 109 ILE n 
1 110 ALA n 
1 111 GLU n 
1 112 LEU n 
1 113 SER n 
1 114 GLY n 
1 115 ASN n 
1 116 ARG n 
1 117 PRO n 
1 118 LEU n 
1 119 THR n 
1 120 VAL n 
1 121 ILE n 
1 122 MET n 
1 123 HIS n 
1 124 THR n 
1 125 ILE n 
1 126 PHE n 
1 127 GLN n 
1 128 GLU n 
1 129 ARG n 
1 130 ASP n 
1 131 LEU n 
1 132 LEU n 
1 133 LYS n 
1 134 THR n 
1 135 PHE n 
1 136 LYS n 
1 137 ILE n 
1 138 PRO n 
1 139 VAL n 
1 140 ASP n 
1 141 THR n 
1 142 LEU n 
1 143 ILE n 
1 144 THR n 
1 145 TYR n 
1 146 LEU n 
1 147 MET n 
1 148 THR n 
1 149 LEU n 
1 150 GLU n 
1 151 ASP n 
1 152 HIS n 
1 153 TYR n 
1 154 HIS n 
1 155 ALA n 
1 156 ASP n 
1 157 VAL n 
1 158 ALA n 
1 159 TYR n 
1 160 HIS n 
1 161 ASN n 
1 162 ASN n 
1 163 ILE n 
1 164 HIS n 
1 165 ALA n 
1 166 ALA n 
1 167 ASP n 
1 168 VAL n 
1 169 VAL n 
1 170 GLN n 
1 171 SER n 
1 172 THR n 
1 173 HIS n 
1 174 VAL n 
1 175 LEU n 
1 176 LEU n 
1 177 SER n 
1 178 THR n 
1 179 PRO n 
1 180 ALA n 
1 181 LEU n 
1 182 GLU n 
1 183 ALA n 
1 184 VAL n 
1 185 PHE n 
1 186 THR n 
1 187 ASP n 
1 188 LEU n 
1 189 GLU n 
1 190 ILE n 
1 191 LEU n 
1 192 ALA n 
1 193 ALA n 
1 194 ILE n 
1 195 PHE n 
1 196 ALA n 
1 197 SER n 
1 198 ALA n 
1 199 ILE n 
1 200 HIS n 
1 201 ASP n 
1 202 VAL n 
1 203 ASP n 
1 204 HIS n 
1 205 PRO n 
1 206 GLY n 
1 207 VAL n 
1 208 SER n 
1 209 ASN n 
1 210 GLN n 
1 211 PHE n 
1 212 LEU n 
1 213 ILE n 
1 214 ASN n 
1 215 THR n 
1 216 ASN n 
1 217 SER n 
1 218 GLU n 
1 219 LEU n 
1 220 ALA n 
1 221 LEU n 
1 222 MET n 
1 223 TYR n 
1 224 ASN n 
1 225 ASP n 
1 226 SER n 
1 227 SER n 
1 228 VAL n 
1 229 LEU n 
1 230 GLU n 
1 231 ASN n 
1 232 HIS n 
1 233 HIS n 
1 234 LEU n 
1 235 ALA n 
1 236 VAL n 
1 237 GLY n 
1 238 PHE n 
1 239 LYS n 
1 240 LEU n 
1 241 LEU n 
1 242 GLN n 
1 243 GLU n 
1 244 GLU n 
1 245 ASN n 
1 246 CYS n 
1 247 ASP n 
1 248 ILE n 
1 249 PHE n 
1 250 GLN n 
1 251 ASN n 
1 252 LEU n 
1 253 THR n 
1 254 LYS n 
1 255 LYS n 
1 256 GLN n 
1 257 ARG n 
1 258 GLN n 
1 259 SER n 
1 260 LEU n 
1 261 ARG n 
1 262 LYS n 
1 263 MET n 
1 264 VAL n 
1 265 ILE n 
1 266 ASP n 
1 267 ILE n 
1 268 VAL n 
1 269 LEU n 
1 270 ALA n 
1 271 THR n 
1 272 ASP n 
1 273 MET n 
1 274 SER n 
1 275 LYS n 
1 276 HIS n 
1 277 MET n 
1 278 ASN n 
1 279 LEU n 
1 280 LEU n 
1 281 ALA n 
1 282 ASP n 
1 283 LEU n 
1 284 LYS n 
1 285 THR n 
1 286 MET n 
1 287 VAL n 
1 288 GLU n 
1 289 THR n 
1 290 LYS n 
1 291 LYS n 
1 292 VAL n 
1 293 THR n 
1 294 SER n 
1 295 SER n 
1 296 GLY n 
1 297 VAL n 
1 298 LEU n 
1 299 LEU n 
1 300 LEU n 
1 301 ASP n 
1 302 ASN n 
1 303 TYR n 
1 304 SER n 
1 305 ASP n 
1 306 ARG n 
1 307 ILE n 
1 308 GLN n 
1 309 VAL n 
1 310 LEU n 
1 311 GLN n 
1 312 ASN n 
1 313 MET n 
1 314 VAL n 
1 315 HIS n 
1 316 CYS n 
1 317 ALA n 
1 318 ASP n 
1 319 LEU n 
1 320 SER n 
1 321 ASN n 
1 322 PRO n 
1 323 THR n 
1 324 LYS n 
1 325 PRO n 
1 326 LEU n 
1 327 GLN n 
1 328 LEU n 
1 329 TYR n 
1 330 ARG n 
1 331 GLN n 
1 332 TRP n 
1 333 THR n 
1 334 ASP n 
1 335 ARG n 
1 336 ILE n 
1 337 MET n 
1 338 GLU n 
1 339 GLU n 
1 340 PHE n 
1 341 PHE n 
1 342 ARG n 
1 343 GLN n 
1 344 GLY n 
1 345 ASP n 
1 346 ARG n 
1 347 GLU n 
1 348 ARG n 
1 349 GLU n 
1 350 ARG n 
1 351 GLY n 
1 352 MET n 
1 353 GLU n 
1 354 ILE n 
1 355 SER n 
1 356 PRO n 
1 357 MET n 
1 358 CYS n 
1 359 ASP n 
1 360 LYS n 
1 361 HIS n 
1 362 ASN n 
1 363 ALA n 
1 364 SER n 
1 365 VAL n 
1 366 GLU n 
1 367 LYS n 
1 368 SER n 
1 369 GLN n 
1 370 VAL n 
1 371 GLY n 
1 372 PHE n 
1 373 ILE n 
1 374 ASP n 
1 375 TYR n 
1 376 ILE n 
1 377 VAL n 
1 378 HIS n 
1 379 PRO n 
1 380 LEU n 
1 381 TRP n 
1 382 GLU n 
1 383 THR n 
1 384 TRP n 
1 385 ALA n 
1 386 ASP n 
1 387 LEU n 
1 388 VAL n 
1 389 HIS n 
1 390 PRO n 
1 391 ASP n 
1 392 ALA n 
1 393 GLN n 
1 394 ASP n 
1 395 ILE n 
1 396 LEU n 
1 397 ASP n 
1 398 THR n 
1 399 LEU n 
1 400 GLU n 
1 401 ASP n 
1 402 ASN n 
1 403 ARG n 
1 404 GLU n 
1 405 TRP n 
1 406 TYR n 
1 407 GLN n 
1 408 SER n 
1 409 THR n 
1 410 ILE n 
1 411 PRO n 
1 412 GLN n 
1 413 SER n 
1 414 PRO n 
1 415 SER n 
1 416 PRO n 
1 417 ALA n 
1 418 PRO n 
1 419 ASP n 
1 420 ASP n 
1 421 PRO n 
1 422 GLU n 
1 423 GLU n 
1 424 GLY n 
1 425 ARG n 
1 426 GLN n 
1 427 GLY n 
1 428 GLN n 
1 429 THR n 
1 430 GLU n 
1 431 LYS n 
1 432 PHE n 
1 433 GLN n 
1 434 PHE n 
1 435 GLU n 
1 436 LEU n 
1 437 THR n 
1 438 LEU n 
1 439 GLU n 
1 440 GLU n 
1 441 ASP n 
1 442 GLY n 
1 443 GLU n 
1 444 SER n 
1 445 ASP n 
1 446 THR n 
1 447 GLU n 
1 448 LYS n 
1 449 ASP n 
1 450 SER n 
1 451 GLY n 
1 452 SER n 
1 453 GLN n 
1 454 VAL n 
1 455 GLU n 
1 456 GLU n 
1 457 ASP n 
1 458 THR n 
1 459 SER n 
1 460 CYS n 
1 461 SER n 
1 462 ASP n 
1 463 SER n 
1 464 LYS n 
1 465 THR n 
1 466 LEU n 
1 467 CYS n 
1 468 THR n 
1 469 GLN n 
1 470 ASP n 
1 471 SER n 
1 472 GLU n 
1 473 SER n 
1 474 THR n 
1 475 GLU n 
1 476 ILE n 
1 477 PRO n 
1 478 LEU n 
1 479 ASP n 
1 480 GLU n 
1 481 GLN n 
1 482 VAL n 
1 483 GLU n 
1 484 GLU n 
1 485 GLU n 
1 486 ALA n 
1 487 VAL n 
1 488 GLY n 
1 489 GLU n 
1 490 GLU n 
1 491 GLU n 
1 492 GLU n 
1 493 SER n 
1 494 GLN n 
1 495 PRO n 
1 496 GLU n 
1 497 ALA n 
1 498 CYS n 
1 499 VAL n 
1 500 ILE n 
1 501 ASP n 
1 502 ASP n 
1 503 ARG n 
1 504 SER n 
1 505 PRO n 
1 506 ASP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   506 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'PDE4D, DPDE3' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     511693 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1D8Q non-polymer         . 
'(3~{Z})-3-[[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]methylidene]-6-oxidanyl-1~{H}-indol-2-one' ? 'C21 H19 F2 N O4' 
387.377 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ? 'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'   149.211 
MG    non-polymer         . 'MAGNESIUM ION' ? 'Mg 2'            24.305  
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'      119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'   204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'     117.146 
ZN    non-polymer         . 'ZINC ION' ? 'Zn 2'            65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   SER 3   3   ?   ?   ?   A . n 
A 1 4   ASN 4   4   ?   ?   ?   A . n 
A 1 5   LYS 5   5   ?   ?   ?   A . n 
A 1 6   PHE 6   6   ?   ?   ?   A . n 
A 1 7   LYS 7   7   ?   ?   ?   A . n 
A 1 8   ARG 8   8   ?   ?   ?   A . n 
A 1 9   MET 9   9   ?   ?   ?   A . n 
A 1 10  LEU 10  10  ?   ?   ?   A . n 
A 1 11  ASN 11  11  ?   ?   ?   A . n 
A 1 12  ARG 12  12  ?   ?   ?   A . n 
A 1 13  GLU 13  13  ?   ?   ?   A . n 
A 1 14  LEU 14  14  ?   ?   ?   A . n 
A 1 15  THR 15  15  ?   ?   ?   A . n 
A 1 16  HIS 16  16  ?   ?   ?   A . n 
A 1 17  LEU 17  17  ?   ?   ?   A . n 
A 1 18  SER 18  18  ?   ?   ?   A . n 
A 1 19  GLU 19  19  ?   ?   ?   A . n 
A 1 20  MET 20  20  ?   ?   ?   A . n 
A 1 21  SER 21  21  ?   ?   ?   A . n 
A 1 22  ARG 22  22  ?   ?   ?   A . n 
A 1 23  SER 23  23  ?   ?   ?   A . n 
A 1 24  GLY 24  24  ?   ?   ?   A . n 
A 1 25  ASN 25  25  ?   ?   ?   A . n 
A 1 26  GLN 26  26  ?   ?   ?   A . n 
A 1 27  VAL 27  27  ?   ?   ?   A . n 
A 1 28  SER 28  28  ?   ?   ?   A . n 
A 1 29  GLU 29  29  ?   ?   ?   A . n 
A 1 30  PHE 30  30  ?   ?   ?   A . n 
A 1 31  ILE 31  31  ?   ?   ?   A . n 
A 1 32  SER 32  32  ?   ?   ?   A . n 
A 1 33  ASN 33  33  ?   ?   ?   A . n 
A 1 34  THR 34  34  ?   ?   ?   A . n 
A 1 35  PHE 35  35  ?   ?   ?   A . n 
A 1 36  LEU 36  36  ?   ?   ?   A . n 
A 1 37  ASP 37  37  ?   ?   ?   A . n 
A 1 38  LYS 38  38  ?   ?   ?   A . n 
A 1 39  GLN 39  39  ?   ?   ?   A . n 
A 1 40  HIS 40  40  ?   ?   ?   A . n 
A 1 41  GLU 41  41  ?   ?   ?   A . n 
A 1 42  VAL 42  42  ?   ?   ?   A . n 
A 1 43  GLU 43  43  ?   ?   ?   A . n 
A 1 44  ILE 44  44  ?   ?   ?   A . n 
A 1 45  PRO 45  45  ?   ?   ?   A . n 
A 1 46  SER 46  46  ?   ?   ?   A . n 
A 1 47  PRO 47  47  ?   ?   ?   A . n 
A 1 48  THR 48  48  ?   ?   ?   A . n 
A 1 49  GLN 49  49  ?   ?   ?   A . n 
A 1 50  LYS 50  50  ?   ?   ?   A . n 
A 1 51  GLU 51  51  ?   ?   ?   A . n 
A 1 52  LYS 52  52  ?   ?   ?   A . n 
A 1 53  GLU 53  53  ?   ?   ?   A . n 
A 1 54  LYS 54  54  ?   ?   ?   A . n 
A 1 55  LYS 55  55  ?   ?   ?   A . n 
A 1 56  LYS 56  56  ?   ?   ?   A . n 
A 1 57  ARG 57  57  ?   ?   ?   A . n 
A 1 58  PRO 58  58  ?   ?   ?   A . n 
A 1 59  MET 59  59  ?   ?   ?   A . n 
A 1 60  SER 60  60  ?   ?   ?   A . n 
A 1 61  GLN 61  61  ?   ?   ?   A . n 
A 1 62  ILE 62  62  ?   ?   ?   A . n 
A 1 63  SER 63  63  ?   ?   ?   A . n 
A 1 64  GLY 64  64  ?   ?   ?   A . n 
A 1 65  VAL 65  65  ?   ?   ?   A . n 
A 1 66  LYS 66  66  ?   ?   ?   A . n 
A 1 67  LYS 67  67  ?   ?   ?   A . n 
A 1 68  LEU 68  68  ?   ?   ?   A . n 
A 1 69  MET 69  69  ?   ?   ?   A . n 
A 1 70  HIS 70  70  ?   ?   ?   A . n 
A 1 71  SER 71  71  ?   ?   ?   A . n 
A 1 72  SER 72  72  ?   ?   ?   A . n 
A 1 73  SER 73  73  ?   ?   ?   A . n 
A 1 74  LEU 74  74  ?   ?   ?   A . n 
A 1 75  THR 75  75  ?   ?   ?   A . n 
A 1 76  ASN 76  76  ?   ?   ?   A . n 
A 1 77  SER 77  77  ?   ?   ?   A . n 
A 1 78  SER 78  78  ?   ?   ?   A . n 
A 1 79  ILE 79  79  ?   ?   ?   A . n 
A 1 80  PRO 80  80  ?   ?   ?   A . n 
A 1 81  ARG 81  81  ?   ?   ?   A . n 
A 1 82  PHE 82  82  ?   ?   ?   A . n 
A 1 83  GLY 83  83  ?   ?   ?   A . n 
A 1 84  VAL 84  84  ?   ?   ?   A . n 
A 1 85  LYS 85  85  ?   ?   ?   A . n 
A 1 86  THR 86  86  ?   ?   ?   A . n 
A 1 87  GLU 87  87  ?   ?   ?   A . n 
A 1 88  GLN 88  88  ?   ?   ?   A . n 
A 1 89  GLU 89  89  ?   ?   ?   A . n 
A 1 90  ASP 90  90  90  ASP ASP A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  ALA 93  93  93  ALA ALA A . n 
A 1 94  LYS 94  94  94  LYS LYS A . n 
A 1 95  GLU 95  95  95  GLU GLU A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  GLU 97  97  97  GLU GLU A . n 
A 1 98  ASP 98  98  98  ASP ASP A . n 
A 1 99  VAL 99  99  99  VAL VAL A . n 
A 1 100 ASN 100 100 100 ASN ASN A . n 
A 1 101 LYS 101 101 101 LYS LYS A . n 
A 1 102 TRP 102 102 102 TRP TRP A . n 
A 1 103 GLY 103 103 103 GLY GLY A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 HIS 105 105 105 HIS HIS A . n 
A 1 106 VAL 106 106 106 VAL VAL A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 ARG 108 108 108 ARG ARG A . n 
A 1 109 ILE 109 109 109 ILE ILE A . n 
A 1 110 ALA 110 110 110 ALA ALA A . n 
A 1 111 GLU 111 111 111 GLU GLU A . n 
A 1 112 LEU 112 112 112 LEU LEU A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 GLY 114 114 114 GLY GLY A . n 
A 1 115 ASN 115 115 115 ASN ASN A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 PRO 117 117 117 PRO PRO A . n 
A 1 118 LEU 118 118 118 LEU LEU A . n 
A 1 119 THR 119 119 119 THR THR A . n 
A 1 120 VAL 120 120 120 VAL VAL A . n 
A 1 121 ILE 121 121 121 ILE ILE A . n 
A 1 122 MET 122 122 122 MET MET A . n 
A 1 123 HIS 123 123 123 HIS HIS A . n 
A 1 124 THR 124 124 124 THR THR A . n 
A 1 125 ILE 125 125 125 ILE ILE A . n 
A 1 126 PHE 126 126 126 PHE PHE A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 GLU 128 128 128 GLU GLU A . n 
A 1 129 ARG 129 129 129 ARG ARG A . n 
A 1 130 ASP 130 130 130 ASP ASP A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 LYS 133 133 133 LYS LYS A . n 
A 1 134 THR 134 134 134 THR THR A . n 
A 1 135 PHE 135 135 135 PHE PHE A . n 
A 1 136 LYS 136 136 136 LYS LYS A . n 
A 1 137 ILE 137 137 137 ILE ILE A . n 
A 1 138 PRO 138 138 138 PRO PRO A . n 
A 1 139 VAL 139 139 139 VAL VAL A . n 
A 1 140 ASP 140 140 140 ASP ASP A . n 
A 1 141 THR 141 141 141 THR THR A . n 
A 1 142 LEU 142 142 142 LEU LEU A . n 
A 1 143 ILE 143 143 143 ILE ILE A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 TYR 145 145 145 TYR TYR A . n 
A 1 146 LEU 146 146 146 LEU LEU A . n 
A 1 147 MET 147 147 147 MET MET A . n 
A 1 148 THR 148 148 148 THR THR A . n 
A 1 149 LEU 149 149 149 LEU LEU A . n 
A 1 150 GLU 150 150 150 GLU GLU A . n 
A 1 151 ASP 151 151 151 ASP ASP A . n 
A 1 152 HIS 152 152 152 HIS HIS A . n 
A 1 153 TYR 153 153 153 TYR TYR A . n 
A 1 154 HIS 154 154 154 HIS HIS A . n 
A 1 155 ALA 155 155 155 ALA ALA A . n 
A 1 156 ASP 156 156 156 ASP ASP A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 ALA 158 158 158 ALA ALA A . n 
A 1 159 TYR 159 159 159 TYR TYR A . n 
A 1 160 HIS 160 160 160 HIS HIS A . n 
A 1 161 ASN 161 161 161 ASN ASN A . n 
A 1 162 ASN 162 162 162 ASN ASN A . n 
A 1 163 ILE 163 163 163 ILE ILE A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 ALA 165 165 165 ALA ALA A . n 
A 1 166 ALA 166 166 166 ALA ALA A . n 
A 1 167 ASP 167 167 167 ASP ASP A . n 
A 1 168 VAL 168 168 168 VAL VAL A . n 
A 1 169 VAL 169 169 169 VAL VAL A . n 
A 1 170 GLN 170 170 170 GLN GLN A . n 
A 1 171 SER 171 171 171 SER SER A . n 
A 1 172 THR 172 172 172 THR THR A . n 
A 1 173 HIS 173 173 173 HIS HIS A . n 
A 1 174 VAL 174 174 174 VAL VAL A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 LEU 176 176 176 LEU LEU A . n 
A 1 177 SER 177 177 177 SER SER A . n 
A 1 178 THR 178 178 178 THR THR A . n 
A 1 179 PRO 179 179 179 PRO PRO A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 LEU 181 181 181 LEU LEU A . n 
A 1 182 GLU 182 182 182 GLU GLU A . n 
A 1 183 ALA 183 183 183 ALA ALA A . n 
A 1 184 VAL 184 184 184 VAL VAL A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 THR 186 186 186 THR THR A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 GLU 189 189 189 GLU GLU A . n 
A 1 190 ILE 190 190 190 ILE ILE A . n 
A 1 191 LEU 191 191 191 LEU LEU A . n 
A 1 192 ALA 192 192 192 ALA ALA A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 PHE 195 195 195 PHE PHE A . n 
A 1 196 ALA 196 196 196 ALA ALA A . n 
A 1 197 SER 197 197 197 SER SER A . n 
A 1 198 ALA 198 198 198 ALA ALA A . n 
A 1 199 ILE 199 199 199 ILE ILE A . n 
A 1 200 HIS 200 200 200 HIS HIS A . n 
A 1 201 ASP 201 201 201 ASP ASP A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASP 203 203 203 ASP ASP A . n 
A 1 204 HIS 204 204 204 HIS HIS A . n 
A 1 205 PRO 205 205 205 PRO PRO A . n 
A 1 206 GLY 206 206 206 GLY GLY A . n 
A 1 207 VAL 207 207 207 VAL VAL A . n 
A 1 208 SER 208 208 208 SER SER A . n 
A 1 209 ASN 209 209 209 ASN ASN A . n 
A 1 210 GLN 210 210 210 GLN GLN A . n 
A 1 211 PHE 211 211 211 PHE PHE A . n 
A 1 212 LEU 212 212 212 LEU LEU A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 THR 215 215 215 THR THR A . n 
A 1 216 ASN 216 216 216 ASN ASN A . n 
A 1 217 SER 217 217 217 SER SER A . n 
A 1 218 GLU 218 218 218 GLU GLU A . n 
A 1 219 LEU 219 219 219 LEU LEU A . n 
A 1 220 ALA 220 220 220 ALA ALA A . n 
A 1 221 LEU 221 221 221 LEU LEU A . n 
A 1 222 MET 222 222 222 MET MET A . n 
A 1 223 TYR 223 223 223 TYR TYR A . n 
A 1 224 ASN 224 224 224 ASN ASN A . n 
A 1 225 ASP 225 225 225 ASP ASP A . n 
A 1 226 SER 226 226 226 SER SER A . n 
A 1 227 SER 227 227 227 SER SER A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 LEU 229 229 229 LEU LEU A . n 
A 1 230 GLU 230 230 230 GLU GLU A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 HIS 232 232 232 HIS HIS A . n 
A 1 233 HIS 233 233 233 HIS HIS A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 ALA 235 235 235 ALA ALA A . n 
A 1 236 VAL 236 236 236 VAL VAL A . n 
A 1 237 GLY 237 237 237 GLY GLY A . n 
A 1 238 PHE 238 238 238 PHE PHE A . n 
A 1 239 LYS 239 239 239 LYS LYS A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 LEU 241 241 241 LEU LEU A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 GLU 243 243 243 GLU GLU A . n 
A 1 244 GLU 244 244 244 GLU GLU A . n 
A 1 245 ASN 245 245 245 ASN ASN A . n 
A 1 246 CYS 246 246 246 CYS CYS A . n 
A 1 247 ASP 247 247 247 ASP ASP A . n 
A 1 248 ILE 248 248 248 ILE ILE A . n 
A 1 249 PHE 249 249 249 PHE PHE A . n 
A 1 250 GLN 250 250 250 GLN GLN A . n 
A 1 251 ASN 251 251 251 ASN ASN A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 THR 253 253 253 THR THR A . n 
A 1 254 LYS 254 254 254 LYS LYS A . n 
A 1 255 LYS 255 255 255 LYS LYS A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 ARG 257 257 257 ARG ARG A . n 
A 1 258 GLN 258 258 258 GLN GLN A . n 
A 1 259 SER 259 259 259 SER SER A . n 
A 1 260 LEU 260 260 260 LEU LEU A . n 
A 1 261 ARG 261 261 261 ARG ARG A . n 
A 1 262 LYS 262 262 262 LYS LYS A . n 
A 1 263 MET 263 263 263 MET MET A . n 
A 1 264 VAL 264 264 264 VAL VAL A . n 
A 1 265 ILE 265 265 265 ILE ILE A . n 
A 1 266 ASP 266 266 266 ASP ASP A . n 
A 1 267 ILE 267 267 267 ILE ILE A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 LEU 269 269 269 LEU LEU A . n 
A 1 270 ALA 270 270 270 ALA ALA A . n 
A 1 271 THR 271 271 271 THR THR A . n 
A 1 272 ASP 272 272 272 ASP ASP A . n 
A 1 273 MET 273 273 273 MET MET A . n 
A 1 274 SER 274 274 274 SER SER A . n 
A 1 275 LYS 275 275 275 LYS LYS A . n 
A 1 276 HIS 276 276 276 HIS HIS A . n 
A 1 277 MET 277 277 277 MET MET A . n 
A 1 278 ASN 278 278 278 ASN ASN A . n 
A 1 279 LEU 279 279 279 LEU LEU A . n 
A 1 280 LEU 280 280 280 LEU LEU A . n 
A 1 281 ALA 281 281 281 ALA ALA A . n 
A 1 282 ASP 282 282 282 ASP ASP A . n 
A 1 283 LEU 283 283 283 LEU LEU A . n 
A 1 284 LYS 284 284 284 LYS LYS A . n 
A 1 285 THR 285 285 285 THR THR A . n 
A 1 286 MET 286 286 286 MET MET A . n 
A 1 287 VAL 287 287 287 VAL VAL A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 THR 289 289 289 THR THR A . n 
A 1 290 LYS 290 290 290 LYS LYS A . n 
A 1 291 LYS 291 291 291 LYS LYS A . n 
A 1 292 VAL 292 292 292 VAL VAL A . n 
A 1 293 THR 293 293 293 THR THR A . n 
A 1 294 SER 294 294 294 SER SER A . n 
A 1 295 SER 295 295 295 SER SER A . n 
A 1 296 GLY 296 296 296 GLY GLY A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 LEU 300 300 300 LEU LEU A . n 
A 1 301 ASP 301 301 301 ASP ASP A . n 
A 1 302 ASN 302 302 302 ASN ASN A . n 
A 1 303 TYR 303 303 303 TYR TYR A . n 
A 1 304 SER 304 304 304 SER SER A . n 
A 1 305 ASP 305 305 305 ASP ASP A . n 
A 1 306 ARG 306 306 306 ARG ARG A . n 
A 1 307 ILE 307 307 307 ILE ILE A . n 
A 1 308 GLN 308 308 308 GLN GLN A . n 
A 1 309 VAL 309 309 309 VAL VAL A . n 
A 1 310 LEU 310 310 310 LEU LEU A . n 
A 1 311 GLN 311 311 311 GLN GLN A . n 
A 1 312 ASN 312 312 312 ASN ASN A . n 
A 1 313 MET 313 313 313 MET MET A . n 
A 1 314 VAL 314 314 314 VAL VAL A . n 
A 1 315 HIS 315 315 315 HIS HIS A . n 
A 1 316 CYS 316 316 316 CYS CYS A . n 
A 1 317 ALA 317 317 317 ALA ALA A . n 
A 1 318 ASP 318 318 318 ASP ASP A . n 
A 1 319 LEU 319 319 319 LEU LEU A . n 
A 1 320 SER 320 320 320 SER SER A . n 
A 1 321 ASN 321 321 321 ASN ASN A . n 
A 1 322 PRO 322 322 322 PRO PRO A . n 
A 1 323 THR 323 323 323 THR THR A . n 
A 1 324 LYS 324 324 324 LYS LYS A . n 
A 1 325 PRO 325 325 325 PRO PRO A . n 
A 1 326 LEU 326 326 326 LEU LEU A . n 
A 1 327 GLN 327 327 327 GLN GLN A . n 
A 1 328 LEU 328 328 328 LEU LEU A . n 
A 1 329 TYR 329 329 329 TYR TYR A . n 
A 1 330 ARG 330 330 330 ARG ARG A . n 
A 1 331 GLN 331 331 331 GLN GLN A . n 
A 1 332 TRP 332 332 332 TRP TRP A . n 
A 1 333 THR 333 333 333 THR THR A . n 
A 1 334 ASP 334 334 334 ASP ASP A . n 
A 1 335 ARG 335 335 335 ARG ARG A . n 
A 1 336 ILE 336 336 336 ILE ILE A . n 
A 1 337 MET 337 337 337 MET MET A . n 
A 1 338 GLU 338 338 338 GLU GLU A . n 
A 1 339 GLU 339 339 339 GLU GLU A . n 
A 1 340 PHE 340 340 340 PHE PHE A . n 
A 1 341 PHE 341 341 341 PHE PHE A . n 
A 1 342 ARG 342 342 342 ARG ARG A . n 
A 1 343 GLN 343 343 343 GLN GLN A . n 
A 1 344 GLY 344 344 344 GLY GLY A . n 
A 1 345 ASP 345 345 345 ASP ASP A . n 
A 1 346 ARG 346 346 346 ARG ARG A . n 
A 1 347 GLU 347 347 347 GLU GLU A . n 
A 1 348 ARG 348 348 348 ARG ARG A . n 
A 1 349 GLU 349 349 349 GLU GLU A . n 
A 1 350 ARG 350 350 350 ARG ARG A . n 
A 1 351 GLY 351 351 351 GLY GLY A . n 
A 1 352 MET 352 352 352 MET MET A . n 
A 1 353 GLU 353 353 353 GLU GLU A . n 
A 1 354 ILE 354 354 354 ILE ILE A . n 
A 1 355 SER 355 355 355 SER SER A . n 
A 1 356 PRO 356 356 356 PRO PRO A . n 
A 1 357 MET 357 357 357 MET MET A . n 
A 1 358 CYS 358 358 358 CYS CYS A . n 
A 1 359 ASP 359 359 359 ASP ASP A . n 
A 1 360 LYS 360 360 360 LYS LYS A . n 
A 1 361 HIS 361 361 361 HIS HIS A . n 
A 1 362 ASN 362 362 362 ASN ASN A . n 
A 1 363 ALA 363 363 363 ALA ALA A . n 
A 1 364 SER 364 364 364 SER SER A . n 
A 1 365 VAL 365 365 365 VAL VAL A . n 
A 1 366 GLU 366 366 366 GLU GLU A . n 
A 1 367 LYS 367 367 367 LYS LYS A . n 
A 1 368 SER 368 368 368 SER SER A . n 
A 1 369 GLN 369 369 369 GLN GLN A . n 
A 1 370 VAL 370 370 370 VAL VAL A . n 
A 1 371 GLY 371 371 371 GLY GLY A . n 
A 1 372 PHE 372 372 372 PHE PHE A . n 
A 1 373 ILE 373 373 373 ILE ILE A . n 
A 1 374 ASP 374 374 374 ASP ASP A . n 
A 1 375 TYR 375 375 375 TYR TYR A . n 
A 1 376 ILE 376 376 376 ILE ILE A . n 
A 1 377 VAL 377 377 377 VAL VAL A . n 
A 1 378 HIS 378 378 378 HIS HIS A . n 
A 1 379 PRO 379 379 379 PRO PRO A . n 
A 1 380 LEU 380 380 380 LEU LEU A . n 
A 1 381 TRP 381 381 381 TRP TRP A . n 
A 1 382 GLU 382 382 382 GLU GLU A . n 
A 1 383 THR 383 383 383 THR THR A . n 
A 1 384 TRP 384 384 384 TRP TRP A . n 
A 1 385 ALA 385 385 385 ALA ALA A . n 
A 1 386 ASP 386 386 386 ASP ASP A . n 
A 1 387 LEU 387 387 387 LEU LEU A . n 
A 1 388 VAL 388 388 388 VAL VAL A . n 
A 1 389 HIS 389 389 389 HIS HIS A . n 
A 1 390 PRO 390 390 390 PRO PRO A . n 
A 1 391 ASP 391 391 391 ASP ASP A . n 
A 1 392 ALA 392 392 392 ALA ALA A . n 
A 1 393 GLN 393 393 393 GLN GLN A . n 
A 1 394 ASP 394 394 394 ASP ASP A . n 
A 1 395 ILE 395 395 395 ILE ILE A . n 
A 1 396 LEU 396 396 396 LEU LEU A . n 
A 1 397 ASP 397 397 397 ASP ASP A . n 
A 1 398 THR 398 398 398 THR THR A . n 
A 1 399 LEU 399 399 399 LEU LEU A . n 
A 1 400 GLU 400 400 400 GLU GLU A . n 
A 1 401 ASP 401 401 401 ASP ASP A . n 
A 1 402 ASN 402 402 402 ASN ASN A . n 
A 1 403 ARG 403 403 403 ARG ARG A . n 
A 1 404 GLU 404 404 404 GLU GLU A . n 
A 1 405 TRP 405 405 405 TRP TRP A . n 
A 1 406 TYR 406 406 406 TYR TYR A . n 
A 1 407 GLN 407 407 407 GLN GLN A . n 
A 1 408 SER 408 408 408 SER SER A . n 
A 1 409 THR 409 409 409 THR THR A . n 
A 1 410 ILE 410 410 410 ILE ILE A . n 
A 1 411 PRO 411 411 411 PRO PRO A . n 
A 1 412 GLN 412 412 ?   ?   ?   A . n 
A 1 413 SER 413 413 ?   ?   ?   A . n 
A 1 414 PRO 414 414 ?   ?   ?   A . n 
A 1 415 SER 415 415 ?   ?   ?   A . n 
A 1 416 PRO 416 416 ?   ?   ?   A . n 
A 1 417 ALA 417 417 ?   ?   ?   A . n 
A 1 418 PRO 418 418 ?   ?   ?   A . n 
A 1 419 ASP 419 419 ?   ?   ?   A . n 
A 1 420 ASP 420 420 ?   ?   ?   A . n 
A 1 421 PRO 421 421 ?   ?   ?   A . n 
A 1 422 GLU 422 422 ?   ?   ?   A . n 
A 1 423 GLU 423 423 ?   ?   ?   A . n 
A 1 424 GLY 424 424 ?   ?   ?   A . n 
A 1 425 ARG 425 425 ?   ?   ?   A . n 
A 1 426 GLN 426 426 ?   ?   ?   A . n 
A 1 427 GLY 427 427 ?   ?   ?   A . n 
A 1 428 GLN 428 428 ?   ?   ?   A . n 
A 1 429 THR 429 429 ?   ?   ?   A . n 
A 1 430 GLU 430 430 ?   ?   ?   A . n 
A 1 431 LYS 431 431 ?   ?   ?   A . n 
A 1 432 PHE 432 432 ?   ?   ?   A . n 
A 1 433 GLN 433 433 ?   ?   ?   A . n 
A 1 434 PHE 434 434 ?   ?   ?   A . n 
A 1 435 GLU 435 435 ?   ?   ?   A . n 
A 1 436 LEU 436 436 ?   ?   ?   A . n 
A 1 437 THR 437 437 ?   ?   ?   A . n 
A 1 438 LEU 438 438 ?   ?   ?   A . n 
A 1 439 GLU 439 439 ?   ?   ?   A . n 
A 1 440 GLU 440 440 ?   ?   ?   A . n 
A 1 441 ASP 441 441 ?   ?   ?   A . n 
A 1 442 GLY 442 442 ?   ?   ?   A . n 
A 1 443 GLU 443 443 ?   ?   ?   A . n 
A 1 444 SER 444 444 ?   ?   ?   A . n 
A 1 445 ASP 445 445 ?   ?   ?   A . n 
A 1 446 THR 446 446 ?   ?   ?   A . n 
A 1 447 GLU 447 447 ?   ?   ?   A . n 
A 1 448 LYS 448 448 ?   ?   ?   A . n 
A 1 449 ASP 449 449 ?   ?   ?   A . n 
A 1 450 SER 450 450 ?   ?   ?   A . n 
A 1 451 GLY 451 451 ?   ?   ?   A . n 
A 1 452 SER 452 452 ?   ?   ?   A . n 
A 1 453 GLN 453 453 ?   ?   ?   A . n 
A 1 454 VAL 454 454 ?   ?   ?   A . n 
A 1 455 GLU 455 455 ?   ?   ?   A . n 
A 1 456 GLU 456 456 ?   ?   ?   A . n 
A 1 457 ASP 457 457 ?   ?   ?   A . n 
A 1 458 THR 458 458 ?   ?   ?   A . n 
A 1 459 SER 459 459 ?   ?   ?   A . n 
A 1 460 CYS 460 460 ?   ?   ?   A . n 
A 1 461 SER 461 461 ?   ?   ?   A . n 
A 1 462 ASP 462 462 ?   ?   ?   A . n 
A 1 463 SER 463 463 ?   ?   ?   A . n 
A 1 464 LYS 464 464 ?   ?   ?   A . n 
A 1 465 THR 465 465 ?   ?   ?   A . n 
A 1 466 LEU 466 466 ?   ?   ?   A . n 
A 1 467 CYS 467 467 ?   ?   ?   A . n 
A 1 468 THR 468 468 ?   ?   ?   A . n 
A 1 469 GLN 469 469 ?   ?   ?   A . n 
A 1 470 ASP 470 470 ?   ?   ?   A . n 
A 1 471 SER 471 471 ?   ?   ?   A . n 
A 1 472 GLU 472 472 ?   ?   ?   A . n 
A 1 473 SER 473 473 ?   ?   ?   A . n 
A 1 474 THR 474 474 ?   ?   ?   A . n 
A 1 475 GLU 475 475 ?   ?   ?   A . n 
A 1 476 ILE 476 476 ?   ?   ?   A . n 
A 1 477 PRO 477 477 ?   ?   ?   A . n 
A 1 478 LEU 478 478 ?   ?   ?   A . n 
A 1 479 ASP 479 479 ?   ?   ?   A . n 
A 1 480 GLU 480 480 ?   ?   ?   A . n 
A 1 481 GLN 481 481 ?   ?   ?   A . n 
A 1 482 VAL 482 482 ?   ?   ?   A . n 
A 1 483 GLU 483 483 ?   ?   ?   A . n 
A 1 484 GLU 484 484 ?   ?   ?   A . n 
A 1 485 GLU 485 485 ?   ?   ?   A . n 
A 1 486 ALA 486 486 ?   ?   ?   A . n 
A 1 487 VAL 487 487 ?   ?   ?   A . n 
A 1 488 GLY 488 488 ?   ?   ?   A . n 
A 1 489 GLU 489 489 ?   ?   ?   A . n 
A 1 490 GLU 490 490 ?   ?   ?   A . n 
A 1 491 GLU 491 491 ?   ?   ?   A . n 
A 1 492 GLU 492 492 ?   ?   ?   A . n 
A 1 493 SER 493 493 ?   ?   ?   A . n 
A 1 494 GLN 494 494 ?   ?   ?   A . n 
A 1 495 PRO 495 495 ?   ?   ?   A . n 
A 1 496 GLU 496 496 ?   ?   ?   A . n 
A 1 497 ALA 497 497 ?   ?   ?   A . n 
A 1 498 CYS 498 498 ?   ?   ?   A . n 
A 1 499 VAL 499 499 ?   ?   ?   A . n 
A 1 500 ILE 500 500 ?   ?   ?   A . n 
A 1 501 ASP 501 501 ?   ?   ?   A . n 
A 1 502 ASP 502 502 ?   ?   ?   A . n 
A 1 503 ARG 503 503 ?   ?   ?   A . n 
A 1 504 SER 504 504 ?   ?   ?   A . n 
A 1 505 PRO 505 505 ?   ?   ?   A . n 
A 1 506 ASP 506 506 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   ALA 2   2   ?   ?   ?   B . n 
B 1 3   SER 3   3   ?   ?   ?   B . n 
B 1 4   ASN 4   4   ?   ?   ?   B . n 
B 1 5   LYS 5   5   ?   ?   ?   B . n 
B 1 6   PHE 6   6   ?   ?   ?   B . n 
B 1 7   LYS 7   7   ?   ?   ?   B . n 
B 1 8   ARG 8   8   ?   ?   ?   B . n 
B 1 9   MET 9   9   ?   ?   ?   B . n 
B 1 10  LEU 10  10  ?   ?   ?   B . n 
B 1 11  ASN 11  11  ?   ?   ?   B . n 
B 1 12  ARG 12  12  ?   ?   ?   B . n 
B 1 13  GLU 13  13  ?   ?   ?   B . n 
B 1 14  LEU 14  14  ?   ?   ?   B . n 
B 1 15  THR 15  15  ?   ?   ?   B . n 
B 1 16  HIS 16  16  ?   ?   ?   B . n 
B 1 17  LEU 17  17  ?   ?   ?   B . n 
B 1 18  SER 18  18  ?   ?   ?   B . n 
B 1 19  GLU 19  19  ?   ?   ?   B . n 
B 1 20  MET 20  20  ?   ?   ?   B . n 
B 1 21  SER 21  21  ?   ?   ?   B . n 
B 1 22  ARG 22  22  ?   ?   ?   B . n 
B 1 23  SER 23  23  ?   ?   ?   B . n 
B 1 24  GLY 24  24  ?   ?   ?   B . n 
B 1 25  ASN 25  25  ?   ?   ?   B . n 
B 1 26  GLN 26  26  ?   ?   ?   B . n 
B 1 27  VAL 27  27  ?   ?   ?   B . n 
B 1 28  SER 28  28  ?   ?   ?   B . n 
B 1 29  GLU 29  29  ?   ?   ?   B . n 
B 1 30  PHE 30  30  ?   ?   ?   B . n 
B 1 31  ILE 31  31  ?   ?   ?   B . n 
B 1 32  SER 32  32  ?   ?   ?   B . n 
B 1 33  ASN 33  33  ?   ?   ?   B . n 
B 1 34  THR 34  34  ?   ?   ?   B . n 
B 1 35  PHE 35  35  ?   ?   ?   B . n 
B 1 36  LEU 36  36  ?   ?   ?   B . n 
B 1 37  ASP 37  37  ?   ?   ?   B . n 
B 1 38  LYS 38  38  ?   ?   ?   B . n 
B 1 39  GLN 39  39  ?   ?   ?   B . n 
B 1 40  HIS 40  40  ?   ?   ?   B . n 
B 1 41  GLU 41  41  ?   ?   ?   B . n 
B 1 42  VAL 42  42  ?   ?   ?   B . n 
B 1 43  GLU 43  43  ?   ?   ?   B . n 
B 1 44  ILE 44  44  ?   ?   ?   B . n 
B 1 45  PRO 45  45  ?   ?   ?   B . n 
B 1 46  SER 46  46  ?   ?   ?   B . n 
B 1 47  PRO 47  47  ?   ?   ?   B . n 
B 1 48  THR 48  48  ?   ?   ?   B . n 
B 1 49  GLN 49  49  ?   ?   ?   B . n 
B 1 50  LYS 50  50  ?   ?   ?   B . n 
B 1 51  GLU 51  51  ?   ?   ?   B . n 
B 1 52  LYS 52  52  ?   ?   ?   B . n 
B 1 53  GLU 53  53  ?   ?   ?   B . n 
B 1 54  LYS 54  54  ?   ?   ?   B . n 
B 1 55  LYS 55  55  ?   ?   ?   B . n 
B 1 56  LYS 56  56  ?   ?   ?   B . n 
B 1 57  ARG 57  57  ?   ?   ?   B . n 
B 1 58  PRO 58  58  ?   ?   ?   B . n 
B 1 59  MET 59  59  ?   ?   ?   B . n 
B 1 60  SER 60  60  ?   ?   ?   B . n 
B 1 61  GLN 61  61  ?   ?   ?   B . n 
B 1 62  ILE 62  62  ?   ?   ?   B . n 
B 1 63  SER 63  63  ?   ?   ?   B . n 
B 1 64  GLY 64  64  ?   ?   ?   B . n 
B 1 65  VAL 65  65  ?   ?   ?   B . n 
B 1 66  LYS 66  66  ?   ?   ?   B . n 
B 1 67  LYS 67  67  ?   ?   ?   B . n 
B 1 68  LEU 68  68  ?   ?   ?   B . n 
B 1 69  MET 69  69  ?   ?   ?   B . n 
B 1 70  HIS 70  70  ?   ?   ?   B . n 
B 1 71  SER 71  71  ?   ?   ?   B . n 
B 1 72  SER 72  72  ?   ?   ?   B . n 
B 1 73  SER 73  73  ?   ?   ?   B . n 
B 1 74  LEU 74  74  ?   ?   ?   B . n 
B 1 75  THR 75  75  ?   ?   ?   B . n 
B 1 76  ASN 76  76  ?   ?   ?   B . n 
B 1 77  SER 77  77  ?   ?   ?   B . n 
B 1 78  SER 78  78  ?   ?   ?   B . n 
B 1 79  ILE 79  79  ?   ?   ?   B . n 
B 1 80  PRO 80  80  ?   ?   ?   B . n 
B 1 81  ARG 81  81  ?   ?   ?   B . n 
B 1 82  PHE 82  82  ?   ?   ?   B . n 
B 1 83  GLY 83  83  ?   ?   ?   B . n 
B 1 84  VAL 84  84  ?   ?   ?   B . n 
B 1 85  LYS 85  85  ?   ?   ?   B . n 
B 1 86  THR 86  86  ?   ?   ?   B . n 
B 1 87  GLU 87  87  ?   ?   ?   B . n 
B 1 88  GLN 88  88  ?   ?   ?   B . n 
B 1 89  GLU 89  89  ?   ?   ?   B . n 
B 1 90  ASP 90  90  90  ASP ASP B . n 
B 1 91  VAL 91  91  91  VAL VAL B . n 
B 1 92  LEU 92  92  92  LEU LEU B . n 
B 1 93  ALA 93  93  93  ALA ALA B . n 
B 1 94  LYS 94  94  94  LYS LYS B . n 
B 1 95  GLU 95  95  95  GLU GLU B . n 
B 1 96  LEU 96  96  96  LEU LEU B . n 
B 1 97  GLU 97  97  97  GLU GLU B . n 
B 1 98  ASP 98  98  98  ASP ASP B . n 
B 1 99  VAL 99  99  99  VAL VAL B . n 
B 1 100 ASN 100 100 100 ASN ASN B . n 
B 1 101 LYS 101 101 101 LYS LYS B . n 
B 1 102 TRP 102 102 102 TRP TRP B . n 
B 1 103 GLY 103 103 103 GLY GLY B . n 
B 1 104 LEU 104 104 104 LEU LEU B . n 
B 1 105 HIS 105 105 105 HIS HIS B . n 
B 1 106 VAL 106 106 106 VAL VAL B . n 
B 1 107 PHE 107 107 107 PHE PHE B . n 
B 1 108 ARG 108 108 108 ARG ARG B . n 
B 1 109 ILE 109 109 109 ILE ILE B . n 
B 1 110 ALA 110 110 110 ALA ALA B . n 
B 1 111 GLU 111 111 111 GLU GLU B . n 
B 1 112 LEU 112 112 112 LEU LEU B . n 
B 1 113 SER 113 113 113 SER SER B . n 
B 1 114 GLY 114 114 114 GLY GLY B . n 
B 1 115 ASN 115 115 115 ASN ASN B . n 
B 1 116 ARG 116 116 116 ARG ARG B . n 
B 1 117 PRO 117 117 117 PRO PRO B . n 
B 1 118 LEU 118 118 118 LEU LEU B . n 
B 1 119 THR 119 119 119 THR THR B . n 
B 1 120 VAL 120 120 120 VAL VAL B . n 
B 1 121 ILE 121 121 121 ILE ILE B . n 
B 1 122 MET 122 122 122 MET MET B . n 
B 1 123 HIS 123 123 123 HIS HIS B . n 
B 1 124 THR 124 124 124 THR THR B . n 
B 1 125 ILE 125 125 125 ILE ILE B . n 
B 1 126 PHE 126 126 126 PHE PHE B . n 
B 1 127 GLN 127 127 127 GLN GLN B . n 
B 1 128 GLU 128 128 128 GLU GLU B . n 
B 1 129 ARG 129 129 129 ARG ARG B . n 
B 1 130 ASP 130 130 130 ASP ASP B . n 
B 1 131 LEU 131 131 131 LEU LEU B . n 
B 1 132 LEU 132 132 132 LEU LEU B . n 
B 1 133 LYS 133 133 133 LYS LYS B . n 
B 1 134 THR 134 134 134 THR THR B . n 
B 1 135 PHE 135 135 135 PHE PHE B . n 
B 1 136 LYS 136 136 136 LYS LYS B . n 
B 1 137 ILE 137 137 137 ILE ILE B . n 
B 1 138 PRO 138 138 138 PRO PRO B . n 
B 1 139 VAL 139 139 139 VAL VAL B . n 
B 1 140 ASP 140 140 140 ASP ASP B . n 
B 1 141 THR 141 141 141 THR THR B . n 
B 1 142 LEU 142 142 142 LEU LEU B . n 
B 1 143 ILE 143 143 143 ILE ILE B . n 
B 1 144 THR 144 144 144 THR THR B . n 
B 1 145 TYR 145 145 145 TYR TYR B . n 
B 1 146 LEU 146 146 146 LEU LEU B . n 
B 1 147 MET 147 147 147 MET MET B . n 
B 1 148 THR 148 148 148 THR THR B . n 
B 1 149 LEU 149 149 149 LEU LEU B . n 
B 1 150 GLU 150 150 150 GLU GLU B . n 
B 1 151 ASP 151 151 151 ASP ASP B . n 
B 1 152 HIS 152 152 152 HIS HIS B . n 
B 1 153 TYR 153 153 153 TYR TYR B . n 
B 1 154 HIS 154 154 154 HIS HIS B . n 
B 1 155 ALA 155 155 155 ALA ALA B . n 
B 1 156 ASP 156 156 156 ASP ASP B . n 
B 1 157 VAL 157 157 157 VAL VAL B . n 
B 1 158 ALA 158 158 158 ALA ALA B . n 
B 1 159 TYR 159 159 159 TYR TYR B . n 
B 1 160 HIS 160 160 160 HIS HIS B . n 
B 1 161 ASN 161 161 161 ASN ASN B . n 
B 1 162 ASN 162 162 162 ASN ASN B . n 
B 1 163 ILE 163 163 163 ILE ILE B . n 
B 1 164 HIS 164 164 164 HIS HIS B . n 
B 1 165 ALA 165 165 165 ALA ALA B . n 
B 1 166 ALA 166 166 166 ALA ALA B . n 
B 1 167 ASP 167 167 167 ASP ASP B . n 
B 1 168 VAL 168 168 168 VAL VAL B . n 
B 1 169 VAL 169 169 169 VAL VAL B . n 
B 1 170 GLN 170 170 170 GLN GLN B . n 
B 1 171 SER 171 171 171 SER SER B . n 
B 1 172 THR 172 172 172 THR THR B . n 
B 1 173 HIS 173 173 173 HIS HIS B . n 
B 1 174 VAL 174 174 174 VAL VAL B . n 
B 1 175 LEU 175 175 175 LEU LEU B . n 
B 1 176 LEU 176 176 176 LEU LEU B . n 
B 1 177 SER 177 177 177 SER SER B . n 
B 1 178 THR 178 178 178 THR THR B . n 
B 1 179 PRO 179 179 179 PRO PRO B . n 
B 1 180 ALA 180 180 180 ALA ALA B . n 
B 1 181 LEU 181 181 181 LEU LEU B . n 
B 1 182 GLU 182 182 182 GLU GLU B . n 
B 1 183 ALA 183 183 183 ALA ALA B . n 
B 1 184 VAL 184 184 184 VAL VAL B . n 
B 1 185 PHE 185 185 185 PHE PHE B . n 
B 1 186 THR 186 186 186 THR THR B . n 
B 1 187 ASP 187 187 187 ASP ASP B . n 
B 1 188 LEU 188 188 188 LEU LEU B . n 
B 1 189 GLU 189 189 189 GLU GLU B . n 
B 1 190 ILE 190 190 190 ILE ILE B . n 
B 1 191 LEU 191 191 191 LEU LEU B . n 
B 1 192 ALA 192 192 192 ALA ALA B . n 
B 1 193 ALA 193 193 193 ALA ALA B . n 
B 1 194 ILE 194 194 194 ILE ILE B . n 
B 1 195 PHE 195 195 195 PHE PHE B . n 
B 1 196 ALA 196 196 196 ALA ALA B . n 
B 1 197 SER 197 197 197 SER SER B . n 
B 1 198 ALA 198 198 198 ALA ALA B . n 
B 1 199 ILE 199 199 199 ILE ILE B . n 
B 1 200 HIS 200 200 200 HIS HIS B . n 
B 1 201 ASP 201 201 201 ASP ASP B . n 
B 1 202 VAL 202 202 202 VAL VAL B . n 
B 1 203 ASP 203 203 203 ASP ASP B . n 
B 1 204 HIS 204 204 204 HIS HIS B . n 
B 1 205 PRO 205 205 205 PRO PRO B . n 
B 1 206 GLY 206 206 206 GLY GLY B . n 
B 1 207 VAL 207 207 207 VAL VAL B . n 
B 1 208 SER 208 208 208 SER SER B . n 
B 1 209 ASN 209 209 209 ASN ASN B . n 
B 1 210 GLN 210 210 210 GLN GLN B . n 
B 1 211 PHE 211 211 211 PHE PHE B . n 
B 1 212 LEU 212 212 212 LEU LEU B . n 
B 1 213 ILE 213 213 213 ILE ILE B . n 
B 1 214 ASN 214 214 214 ASN ASN B . n 
B 1 215 THR 215 215 215 THR THR B . n 
B 1 216 ASN 216 216 216 ASN ASN B . n 
B 1 217 SER 217 217 217 SER SER B . n 
B 1 218 GLU 218 218 218 GLU GLU B . n 
B 1 219 LEU 219 219 219 LEU LEU B . n 
B 1 220 ALA 220 220 220 ALA ALA B . n 
B 1 221 LEU 221 221 221 LEU LEU B . n 
B 1 222 MET 222 222 222 MET MET B . n 
B 1 223 TYR 223 223 223 TYR TYR B . n 
B 1 224 ASN 224 224 224 ASN ASN B . n 
B 1 225 ASP 225 225 225 ASP ASP B . n 
B 1 226 SER 226 226 226 SER SER B . n 
B 1 227 SER 227 227 227 SER SER B . n 
B 1 228 VAL 228 228 228 VAL VAL B . n 
B 1 229 LEU 229 229 229 LEU LEU B . n 
B 1 230 GLU 230 230 230 GLU GLU B . n 
B 1 231 ASN 231 231 231 ASN ASN B . n 
B 1 232 HIS 232 232 232 HIS HIS B . n 
B 1 233 HIS 233 233 233 HIS HIS B . n 
B 1 234 LEU 234 234 234 LEU LEU B . n 
B 1 235 ALA 235 235 235 ALA ALA B . n 
B 1 236 VAL 236 236 236 VAL VAL B . n 
B 1 237 GLY 237 237 237 GLY GLY B . n 
B 1 238 PHE 238 238 238 PHE PHE B . n 
B 1 239 LYS 239 239 239 LYS LYS B . n 
B 1 240 LEU 240 240 240 LEU LEU B . n 
B 1 241 LEU 241 241 241 LEU LEU B . n 
B 1 242 GLN 242 242 242 GLN GLN B . n 
B 1 243 GLU 243 243 243 GLU GLU B . n 
B 1 244 GLU 244 244 244 GLU GLU B . n 
B 1 245 ASN 245 245 245 ASN ASN B . n 
B 1 246 CYS 246 246 246 CYS CYS B . n 
B 1 247 ASP 247 247 247 ASP ASP B . n 
B 1 248 ILE 248 248 248 ILE ILE B . n 
B 1 249 PHE 249 249 249 PHE PHE B . n 
B 1 250 GLN 250 250 250 GLN GLN B . n 
B 1 251 ASN 251 251 251 ASN ASN B . n 
B 1 252 LEU 252 252 252 LEU LEU B . n 
B 1 253 THR 253 253 253 THR THR B . n 
B 1 254 LYS 254 254 254 LYS LYS B . n 
B 1 255 LYS 255 255 255 LYS LYS B . n 
B 1 256 GLN 256 256 256 GLN GLN B . n 
B 1 257 ARG 257 257 257 ARG ARG B . n 
B 1 258 GLN 258 258 258 GLN GLN B . n 
B 1 259 SER 259 259 259 SER SER B . n 
B 1 260 LEU 260 260 260 LEU LEU B . n 
B 1 261 ARG 261 261 261 ARG ARG B . n 
B 1 262 LYS 262 262 262 LYS LYS B . n 
B 1 263 MET 263 263 263 MET MET B . n 
B 1 264 VAL 264 264 264 VAL VAL B . n 
B 1 265 ILE 265 265 265 ILE ILE B . n 
B 1 266 ASP 266 266 266 ASP ASP B . n 
B 1 267 ILE 267 267 267 ILE ILE B . n 
B 1 268 VAL 268 268 268 VAL VAL B . n 
B 1 269 LEU 269 269 269 LEU LEU B . n 
B 1 270 ALA 270 270 270 ALA ALA B . n 
B 1 271 THR 271 271 271 THR THR B . n 
B 1 272 ASP 272 272 272 ASP ASP B . n 
B 1 273 MET 273 273 273 MET MET B . n 
B 1 274 SER 274 274 274 SER SER B . n 
B 1 275 LYS 275 275 275 LYS LYS B . n 
B 1 276 HIS 276 276 276 HIS HIS B . n 
B 1 277 MET 277 277 277 MET MET B . n 
B 1 278 ASN 278 278 278 ASN ASN B . n 
B 1 279 LEU 279 279 279 LEU LEU B . n 
B 1 280 LEU 280 280 280 LEU LEU B . n 
B 1 281 ALA 281 281 281 ALA ALA B . n 
B 1 282 ASP 282 282 282 ASP ASP B . n 
B 1 283 LEU 283 283 283 LEU LEU B . n 
B 1 284 LYS 284 284 284 LYS LYS B . n 
B 1 285 THR 285 285 285 THR THR B . n 
B 1 286 MET 286 286 286 MET MET B . n 
B 1 287 VAL 287 287 287 VAL VAL B . n 
B 1 288 GLU 288 288 288 GLU GLU B . n 
B 1 289 THR 289 289 289 THR THR B . n 
B 1 290 LYS 290 290 290 LYS LYS B . n 
B 1 291 LYS 291 291 291 LYS LYS B . n 
B 1 292 VAL 292 292 292 VAL VAL B . n 
B 1 293 THR 293 293 293 THR THR B . n 
B 1 294 SER 294 294 294 SER SER B . n 
B 1 295 SER 295 295 295 SER SER B . n 
B 1 296 GLY 296 296 296 GLY GLY B . n 
B 1 297 VAL 297 297 297 VAL VAL B . n 
B 1 298 LEU 298 298 298 LEU LEU B . n 
B 1 299 LEU 299 299 299 LEU LEU B . n 
B 1 300 LEU 300 300 300 LEU LEU B . n 
B 1 301 ASP 301 301 301 ASP ASP B . n 
B 1 302 ASN 302 302 302 ASN ASN B . n 
B 1 303 TYR 303 303 303 TYR TYR B . n 
B 1 304 SER 304 304 304 SER SER B . n 
B 1 305 ASP 305 305 305 ASP ASP B . n 
B 1 306 ARG 306 306 306 ARG ARG B . n 
B 1 307 ILE 307 307 307 ILE ILE B . n 
B 1 308 GLN 308 308 308 GLN GLN B . n 
B 1 309 VAL 309 309 309 VAL VAL B . n 
B 1 310 LEU 310 310 310 LEU LEU B . n 
B 1 311 GLN 311 311 311 GLN GLN B . n 
B 1 312 ASN 312 312 312 ASN ASN B . n 
B 1 313 MET 313 313 313 MET MET B . n 
B 1 314 VAL 314 314 314 VAL VAL B . n 
B 1 315 HIS 315 315 315 HIS HIS B . n 
B 1 316 CYS 316 316 316 CYS CYS B . n 
B 1 317 ALA 317 317 317 ALA ALA B . n 
B 1 318 ASP 318 318 318 ASP ASP B . n 
B 1 319 LEU 319 319 319 LEU LEU B . n 
B 1 320 SER 320 320 320 SER SER B . n 
B 1 321 ASN 321 321 321 ASN ASN B . n 
B 1 322 PRO 322 322 322 PRO PRO B . n 
B 1 323 THR 323 323 323 THR THR B . n 
B 1 324 LYS 324 324 324 LYS LYS B . n 
B 1 325 PRO 325 325 325 PRO PRO B . n 
B 1 326 LEU 326 326 326 LEU LEU B . n 
B 1 327 GLN 327 327 327 GLN GLN B . n 
B 1 328 LEU 328 328 328 LEU LEU B . n 
B 1 329 TYR 329 329 329 TYR TYR B . n 
B 1 330 ARG 330 330 330 ARG ARG B . n 
B 1 331 GLN 331 331 331 GLN GLN B . n 
B 1 332 TRP 332 332 332 TRP TRP B . n 
B 1 333 THR 333 333 333 THR THR B . n 
B 1 334 ASP 334 334 334 ASP ASP B . n 
B 1 335 ARG 335 335 335 ARG ARG B . n 
B 1 336 ILE 336 336 336 ILE ILE B . n 
B 1 337 MET 337 337 337 MET MET B . n 
B 1 338 GLU 338 338 338 GLU GLU B . n 
B 1 339 GLU 339 339 339 GLU GLU B . n 
B 1 340 PHE 340 340 340 PHE PHE B . n 
B 1 341 PHE 341 341 341 PHE PHE B . n 
B 1 342 ARG 342 342 342 ARG ARG B . n 
B 1 343 GLN 343 343 343 GLN GLN B . n 
B 1 344 GLY 344 344 344 GLY GLY B . n 
B 1 345 ASP 345 345 345 ASP ASP B . n 
B 1 346 ARG 346 346 346 ARG ARG B . n 
B 1 347 GLU 347 347 347 GLU GLU B . n 
B 1 348 ARG 348 348 348 ARG ARG B . n 
B 1 349 GLU 349 349 349 GLU GLU B . n 
B 1 350 ARG 350 350 350 ARG ARG B . n 
B 1 351 GLY 351 351 351 GLY GLY B . n 
B 1 352 MET 352 352 352 MET MET B . n 
B 1 353 GLU 353 353 353 GLU GLU B . n 
B 1 354 ILE 354 354 354 ILE ILE B . n 
B 1 355 SER 355 355 355 SER SER B . n 
B 1 356 PRO 356 356 356 PRO PRO B . n 
B 1 357 MET 357 357 357 MET MET B . n 
B 1 358 CYS 358 358 358 CYS CYS B . n 
B 1 359 ASP 359 359 359 ASP ASP B . n 
B 1 360 LYS 360 360 360 LYS LYS B . n 
B 1 361 HIS 361 361 361 HIS HIS B . n 
B 1 362 ASN 362 362 362 ASN ASN B . n 
B 1 363 ALA 363 363 363 ALA ALA B . n 
B 1 364 SER 364 364 364 SER SER B . n 
B 1 365 VAL 365 365 365 VAL VAL B . n 
B 1 366 GLU 366 366 366 GLU GLU B . n 
B 1 367 LYS 367 367 367 LYS LYS B . n 
B 1 368 SER 368 368 368 SER SER B . n 
B 1 369 GLN 369 369 369 GLN GLN B . n 
B 1 370 VAL 370 370 370 VAL VAL B . n 
B 1 371 GLY 371 371 371 GLY GLY B . n 
B 1 372 PHE 372 372 372 PHE PHE B . n 
B 1 373 ILE 373 373 373 ILE ILE B . n 
B 1 374 ASP 374 374 374 ASP ASP B . n 
B 1 375 TYR 375 375 375 TYR TYR B . n 
B 1 376 ILE 376 376 376 ILE ILE B . n 
B 1 377 VAL 377 377 377 VAL VAL B . n 
B 1 378 HIS 378 378 378 HIS HIS B . n 
B 1 379 PRO 379 379 379 PRO PRO B . n 
B 1 380 LEU 380 380 380 LEU LEU B . n 
B 1 381 TRP 381 381 381 TRP TRP B . n 
B 1 382 GLU 382 382 382 GLU GLU B . n 
B 1 383 THR 383 383 383 THR THR B . n 
B 1 384 TRP 384 384 384 TRP TRP B . n 
B 1 385 ALA 385 385 385 ALA ALA B . n 
B 1 386 ASP 386 386 386 ASP ASP B . n 
B 1 387 LEU 387 387 387 LEU LEU B . n 
B 1 388 VAL 388 388 388 VAL VAL B . n 
B 1 389 HIS 389 389 389 HIS HIS B . n 
B 1 390 PRO 390 390 390 PRO PRO B . n 
B 1 391 ASP 391 391 391 ASP ASP B . n 
B 1 392 ALA 392 392 392 ALA ALA B . n 
B 1 393 GLN 393 393 393 GLN GLN B . n 
B 1 394 ASP 394 394 394 ASP ASP B . n 
B 1 395 ILE 395 395 395 ILE ILE B . n 
B 1 396 LEU 396 396 396 LEU LEU B . n 
B 1 397 ASP 397 397 397 ASP ASP B . n 
B 1 398 THR 398 398 398 THR THR B . n 
B 1 399 LEU 399 399 399 LEU LEU B . n 
B 1 400 GLU 400 400 400 GLU GLU B . n 
B 1 401 ASP 401 401 401 ASP ASP B . n 
B 1 402 ASN 402 402 402 ASN ASN B . n 
B 1 403 ARG 403 403 403 ARG ARG B . n 
B 1 404 GLU 404 404 404 GLU GLU B . n 
B 1 405 TRP 405 405 405 TRP TRP B . n 
B 1 406 TYR 406 406 406 TYR TYR B . n 
B 1 407 GLN 407 407 407 GLN GLN B . n 
B 1 408 SER 408 408 408 SER SER B . n 
B 1 409 THR 409 409 409 THR THR B . n 
B 1 410 ILE 410 410 410 ILE ILE B . n 
B 1 411 PRO 411 411 411 PRO PRO B . n 
B 1 412 GLN 412 412 ?   ?   ?   B . n 
B 1 413 SER 413 413 ?   ?   ?   B . n 
B 1 414 PRO 414 414 ?   ?   ?   B . n 
B 1 415 SER 415 415 ?   ?   ?   B . n 
B 1 416 PRO 416 416 ?   ?   ?   B . n 
B 1 417 ALA 417 417 ?   ?   ?   B . n 
B 1 418 PRO 418 418 ?   ?   ?   B . n 
B 1 419 ASP 419 419 ?   ?   ?   B . n 
B 1 420 ASP 420 420 ?   ?   ?   B . n 
B 1 421 PRO 421 421 ?   ?   ?   B . n 
B 1 422 GLU 422 422 ?   ?   ?   B . n 
B 1 423 GLU 423 423 ?   ?   ?   B . n 
B 1 424 GLY 424 424 ?   ?   ?   B . n 
B 1 425 ARG 425 425 ?   ?   ?   B . n 
B 1 426 GLN 426 426 ?   ?   ?   B . n 
B 1 427 GLY 427 427 ?   ?   ?   B . n 
B 1 428 GLN 428 428 ?   ?   ?   B . n 
B 1 429 THR 429 429 ?   ?   ?   B . n 
B 1 430 GLU 430 430 ?   ?   ?   B . n 
B 1 431 LYS 431 431 ?   ?   ?   B . n 
B 1 432 PHE 432 432 ?   ?   ?   B . n 
B 1 433 GLN 433 433 ?   ?   ?   B . n 
B 1 434 PHE 434 434 ?   ?   ?   B . n 
B 1 435 GLU 435 435 ?   ?   ?   B . n 
B 1 436 LEU 436 436 ?   ?   ?   B . n 
B 1 437 THR 437 437 ?   ?   ?   B . n 
B 1 438 LEU 438 438 ?   ?   ?   B . n 
B 1 439 GLU 439 439 ?   ?   ?   B . n 
B 1 440 GLU 440 440 ?   ?   ?   B . n 
B 1 441 ASP 441 441 ?   ?   ?   B . n 
B 1 442 GLY 442 442 ?   ?   ?   B . n 
B 1 443 GLU 443 443 ?   ?   ?   B . n 
B 1 444 SER 444 444 ?   ?   ?   B . n 
B 1 445 ASP 445 445 ?   ?   ?   B . n 
B 1 446 THR 446 446 ?   ?   ?   B . n 
B 1 447 GLU 447 447 ?   ?   ?   B . n 
B 1 448 LYS 448 448 ?   ?   ?   B . n 
B 1 449 ASP 449 449 ?   ?   ?   B . n 
B 1 450 SER 450 450 ?   ?   ?   B . n 
B 1 451 GLY 451 451 ?   ?   ?   B . n 
B 1 452 SER 452 452 ?   ?   ?   B . n 
B 1 453 GLN 453 453 ?   ?   ?   B . n 
B 1 454 VAL 454 454 ?   ?   ?   B . n 
B 1 455 GLU 455 455 ?   ?   ?   B . n 
B 1 456 GLU 456 456 ?   ?   ?   B . n 
B 1 457 ASP 457 457 ?   ?   ?   B . n 
B 1 458 THR 458 458 ?   ?   ?   B . n 
B 1 459 SER 459 459 ?   ?   ?   B . n 
B 1 460 CYS 460 460 ?   ?   ?   B . n 
B 1 461 SER 461 461 ?   ?   ?   B . n 
B 1 462 ASP 462 462 ?   ?   ?   B . n 
B 1 463 SER 463 463 ?   ?   ?   B . n 
B 1 464 LYS 464 464 ?   ?   ?   B . n 
B 1 465 THR 465 465 ?   ?   ?   B . n 
B 1 466 LEU 466 466 ?   ?   ?   B . n 
B 1 467 CYS 467 467 ?   ?   ?   B . n 
B 1 468 THR 468 468 ?   ?   ?   B . n 
B 1 469 GLN 469 469 ?   ?   ?   B . n 
B 1 470 ASP 470 470 ?   ?   ?   B . n 
B 1 471 SER 471 471 ?   ?   ?   B . n 
B 1 472 GLU 472 472 ?   ?   ?   B . n 
B 1 473 SER 473 473 ?   ?   ?   B . n 
B 1 474 THR 474 474 ?   ?   ?   B . n 
B 1 475 GLU 475 475 ?   ?   ?   B . n 
B 1 476 ILE 476 476 ?   ?   ?   B . n 
B 1 477 PRO 477 477 ?   ?   ?   B . n 
B 1 478 LEU 478 478 ?   ?   ?   B . n 
B 1 479 ASP 479 479 ?   ?   ?   B . n 
B 1 480 GLU 480 480 ?   ?   ?   B . n 
B 1 481 GLN 481 481 ?   ?   ?   B . n 
B 1 482 VAL 482 482 ?   ?   ?   B . n 
B 1 483 GLU 483 483 ?   ?   ?   B . n 
B 1 484 GLU 484 484 ?   ?   ?   B . n 
B 1 485 GLU 485 485 ?   ?   ?   B . n 
B 1 486 ALA 486 486 ?   ?   ?   B . n 
B 1 487 VAL 487 487 ?   ?   ?   B . n 
B 1 488 GLY 488 488 ?   ?   ?   B . n 
B 1 489 GLU 489 489 ?   ?   ?   B . n 
B 1 490 GLU 490 490 ?   ?   ?   B . n 
B 1 491 GLU 491 491 ?   ?   ?   B . n 
B 1 492 GLU 492 492 ?   ?   ?   B . n 
B 1 493 SER 493 493 ?   ?   ?   B . n 
B 1 494 GLN 494 494 ?   ?   ?   B . n 
B 1 495 PRO 495 495 ?   ?   ?   B . n 
B 1 496 GLU 496 496 ?   ?   ?   B . n 
B 1 497 ALA 497 497 ?   ?   ?   B . n 
B 1 498 CYS 498 498 ?   ?   ?   B . n 
B 1 499 VAL 499 499 ?   ?   ?   B . n 
B 1 500 ILE 500 500 ?   ?   ?   B . n 
B 1 501 ASP 501 501 ?   ?   ?   B . n 
B 1 502 ASP 502 502 ?   ?   ?   B . n 
B 1 503 ARG 503 503 ?   ?   ?   B . n 
B 1 504 SER 504 504 ?   ?   ?   B . n 
B 1 505 PRO 505 505 ?   ?   ?   B . n 
B 1 506 ASP 506 506 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1D8Q 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1D8Q 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 ZN    1   601 5   ZN    ZN  A . 
D 3 MG    1   602 5   MG    MG  A . 
E 4 A1D8Q 1   603 1   A1D8Q 34Z A . 
F 2 ZN    1   601 6   ZN    ZN  B . 
G 3 MG    1   602 6   MG    MG  B . 
H 4 A1D8Q 1   603 2   A1D8Q 34Z B . 
I 5 HOH   1   701 91  HOH   HOH A . 
I 5 HOH   2   702 52  HOH   HOH A . 
I 5 HOH   3   703 23  HOH   HOH A . 
I 5 HOH   4   704 51  HOH   HOH A . 
I 5 HOH   5   705 61  HOH   HOH A . 
I 5 HOH   6   706 63  HOH   HOH A . 
I 5 HOH   7   707 25  HOH   HOH A . 
I 5 HOH   8   708 3   HOH   HOH A . 
I 5 HOH   9   709 107 HOH   HOH A . 
I 5 HOH   10  710 9   HOH   HOH A . 
I 5 HOH   11  711 3   HOH   HOH A . 
I 5 HOH   12  712 11  HOH   HOH A . 
I 5 HOH   13  713 10  HOH   HOH A . 
I 5 HOH   14  714 10  HOH   HOH A . 
I 5 HOH   15  715 38  HOH   HOH A . 
I 5 HOH   16  716 36  HOH   HOH A . 
I 5 HOH   17  717 110 HOH   HOH A . 
I 5 HOH   18  718 8   HOH   HOH A . 
I 5 HOH   19  719 17  HOH   HOH A . 
I 5 HOH   20  720 15  HOH   HOH A . 
I 5 HOH   21  721 4   HOH   HOH A . 
I 5 HOH   22  722 85  HOH   HOH A . 
I 5 HOH   23  723 33  HOH   HOH A . 
I 5 HOH   24  724 3   HOH   HOH A . 
I 5 HOH   25  725 71  HOH   HOH A . 
I 5 HOH   26  726 35  HOH   HOH A . 
I 5 HOH   27  727 30  HOH   HOH A . 
I 5 HOH   28  728 1   HOH   HOH A . 
I 5 HOH   29  729 35  HOH   HOH A . 
I 5 HOH   30  730 75  HOH   HOH A . 
I 5 HOH   31  731 34  HOH   HOH A . 
I 5 HOH   32  732 37  HOH   HOH A . 
I 5 HOH   33  733 93  HOH   HOH A . 
I 5 HOH   34  734 69  HOH   HOH A . 
I 5 HOH   35  735 55  HOH   HOH A . 
I 5 HOH   36  736 16  HOH   HOH A . 
I 5 HOH   37  737 76  HOH   HOH A . 
I 5 HOH   38  738 8   HOH   HOH A . 
I 5 HOH   39  739 41  HOH   HOH A . 
I 5 HOH   40  740 2   HOH   HOH A . 
I 5 HOH   41  741 4   HOH   HOH A . 
I 5 HOH   42  742 39  HOH   HOH A . 
I 5 HOH   43  743 57  HOH   HOH A . 
I 5 HOH   44  744 15  HOH   HOH A . 
I 5 HOH   45  745 7   HOH   HOH A . 
I 5 HOH   46  746 67  HOH   HOH A . 
I 5 HOH   47  747 21  HOH   HOH A . 
I 5 HOH   48  748 3   HOH   HOH A . 
I 5 HOH   49  749 5   HOH   HOH A . 
I 5 HOH   50  750 14  HOH   HOH A . 
I 5 HOH   51  751 6   HOH   HOH A . 
I 5 HOH   52  752 100 HOH   HOH A . 
I 5 HOH   53  753 1   HOH   HOH A . 
I 5 HOH   54  754 88  HOH   HOH A . 
I 5 HOH   55  755 42  HOH   HOH A . 
I 5 HOH   56  756 40  HOH   HOH A . 
I 5 HOH   57  757 2   HOH   HOH A . 
I 5 HOH   58  758 94  HOH   HOH A . 
I 5 HOH   59  759 102 HOH   HOH A . 
I 5 HOH   60  760 104 HOH   HOH A . 
I 5 HOH   61  761 29  HOH   HOH A . 
I 5 HOH   62  762 4   HOH   HOH A . 
I 5 HOH   63  763 53  HOH   HOH A . 
I 5 HOH   64  764 7   HOH   HOH A . 
I 5 HOH   65  765 50  HOH   HOH A . 
I 5 HOH   66  766 79  HOH   HOH A . 
I 5 HOH   67  767 56  HOH   HOH A . 
I 5 HOH   68  768 27  HOH   HOH A . 
I 5 HOH   69  769 25  HOH   HOH A . 
I 5 HOH   70  770 43  HOH   HOH A . 
I 5 HOH   71  771 36  HOH   HOH A . 
I 5 HOH   72  772 3   HOH   HOH A . 
I 5 HOH   73  773 68  HOH   HOH A . 
I 5 HOH   74  774 13  HOH   HOH A . 
I 5 HOH   75  775 73  HOH   HOH A . 
I 5 HOH   76  776 22  HOH   HOH A . 
I 5 HOH   77  777 6   HOH   HOH A . 
I 5 HOH   78  778 72  HOH   HOH A . 
I 5 HOH   79  779 31  HOH   HOH A . 
I 5 HOH   80  780 31  HOH   HOH A . 
I 5 HOH   81  781 2   HOH   HOH A . 
I 5 HOH   82  782 26  HOH   HOH A . 
I 5 HOH   83  783 11  HOH   HOH A . 
I 5 HOH   84  784 96  HOH   HOH A . 
I 5 HOH   85  785 46  HOH   HOH A . 
I 5 HOH   86  786 17  HOH   HOH A . 
I 5 HOH   87  787 81  HOH   HOH A . 
I 5 HOH   88  788 58  HOH   HOH A . 
I 5 HOH   89  789 95  HOH   HOH A . 
I 5 HOH   90  790 59  HOH   HOH A . 
I 5 HOH   91  791 13  HOH   HOH A . 
I 5 HOH   92  792 5   HOH   HOH A . 
I 5 HOH   93  793 33  HOH   HOH A . 
I 5 HOH   94  794 8   HOH   HOH A . 
I 5 HOH   95  795 62  HOH   HOH A . 
I 5 HOH   96  796 89  HOH   HOH A . 
I 5 HOH   97  797 4   HOH   HOH A . 
I 5 HOH   98  798 19  HOH   HOH A . 
I 5 HOH   99  799 111 HOH   HOH A . 
I 5 HOH   100 800 10  HOH   HOH A . 
I 5 HOH   101 801 12  HOH   HOH A . 
I 5 HOH   102 802 5   HOH   HOH A . 
I 5 HOH   103 803 5   HOH   HOH A . 
I 5 HOH   104 804 37  HOH   HOH A . 
I 5 HOH   105 805 54  HOH   HOH A . 
I 5 HOH   106 806 103 HOH   HOH A . 
I 5 HOH   107 807 18  HOH   HOH A . 
J 5 HOH   1   701 34  HOH   HOH B . 
J 5 HOH   2   702 92  HOH   HOH B . 
J 5 HOH   3   703 70  HOH   HOH B . 
J 5 HOH   4   704 44  HOH   HOH B . 
J 5 HOH   5   705 83  HOH   HOH B . 
J 5 HOH   6   706 82  HOH   HOH B . 
J 5 HOH   7   707 5   HOH   HOH B . 
J 5 HOH   8   708 60  HOH   HOH B . 
J 5 HOH   9   709 84  HOH   HOH B . 
J 5 HOH   10  710 11  HOH   HOH B . 
J 5 HOH   11  711 65  HOH   HOH B . 
J 5 HOH   12  712 45  HOH   HOH B . 
J 5 HOH   13  713 16  HOH   HOH B . 
J 5 HOH   14  714 29  HOH   HOH B . 
J 5 HOH   15  715 12  HOH   HOH B . 
J 5 HOH   16  716 7   HOH   HOH B . 
J 5 HOH   17  717 1   HOH   HOH B . 
J 5 HOH   18  718 14  HOH   HOH B . 
J 5 HOH   19  719 2   HOH   HOH B . 
J 5 HOH   20  720 24  HOH   HOH B . 
J 5 HOH   21  721 3   HOH   HOH B . 
J 5 HOH   22  722 9   HOH   HOH B . 
J 5 HOH   23  723 5   HOH   HOH B . 
J 5 HOH   24  724 77  HOH   HOH B . 
J 5 HOH   25  725 24  HOH   HOH B . 
J 5 HOH   26  726 99  HOH   HOH B . 
J 5 HOH   27  727 19  HOH   HOH B . 
J 5 HOH   28  728 30  HOH   HOH B . 
J 5 HOH   29  729 32  HOH   HOH B . 
J 5 HOH   30  730 6   HOH   HOH B . 
J 5 HOH   31  731 2   HOH   HOH B . 
J 5 HOH   32  732 10  HOH   HOH B . 
J 5 HOH   33  733 86  HOH   HOH B . 
J 5 HOH   34  734 7   HOH   HOH B . 
J 5 HOH   35  735 22  HOH   HOH B . 
J 5 HOH   36  736 8   HOH   HOH B . 
J 5 HOH   37  737 66  HOH   HOH B . 
J 5 HOH   38  738 4   HOH   HOH B . 
J 5 HOH   39  739 109 HOH   HOH B . 
J 5 HOH   40  740 28  HOH   HOH B . 
J 5 HOH   41  741 80  HOH   HOH B . 
J 5 HOH   42  742 1   HOH   HOH B . 
J 5 HOH   43  743 47  HOH   HOH B . 
J 5 HOH   44  744 18  HOH   HOH B . 
J 5 HOH   45  745 90  HOH   HOH B . 
J 5 HOH   46  746 12  HOH   HOH B . 
J 5 HOH   47  747 20  HOH   HOH B . 
J 5 HOH   48  748 28  HOH   HOH B . 
J 5 HOH   49  749 64  HOH   HOH B . 
J 5 HOH   50  750 20  HOH   HOH B . 
J 5 HOH   51  751 49  HOH   HOH B . 
J 5 HOH   52  752 9   HOH   HOH B . 
J 5 HOH   53  753 23  HOH   HOH B . 
J 5 HOH   54  754 108 HOH   HOH B . 
J 5 HOH   55  755 9   HOH   HOH B . 
J 5 HOH   56  756 74  HOH   HOH B . 
J 5 HOH   57  757 97  HOH   HOH B . 
J 5 HOH   58  758 1   HOH   HOH B . 
J 5 HOH   59  759 38  HOH   HOH B . 
J 5 HOH   60  760 27  HOH   HOH B . 
J 5 HOH   61  761 106 HOH   HOH B . 
J 5 HOH   62  762 112 HOH   HOH B . 
J 5 HOH   63  763 21  HOH   HOH B . 
J 5 HOH   64  764 87  HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? V8        1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.10_2155 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? 171.39.46 3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZQW 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     57.767 
_cell.length_a_esd                 ? 
_cell.length_b                     80.220 
_cell.length_b_esd                 ? 
_cell.length_c                     162.931 
_cell.length_c_esd                 ? 
_cell.volume                       755030.630 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZQW 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZQW 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.63 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          24.73 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M HEPES (pH 7.4), 0.1M MgCl2, 15% PEG3350, 10% isopropanol, 25% ethylene glycol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU HyPix-3000' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-12-17 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.5418 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.5418 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          21.3104556492 
_reflns.entry_id                                       8ZQW 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.1 
_reflns.d_resolution_low                               23.4975 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     44865 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.5 
_reflns.pdbx_netI_over_av_sigmaI                       16.2 
_reflns.pdbx_netI_over_sigmaI                          16.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.074 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.1 
_reflns_shell.d_res_low                                     2.2 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           3.4 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4404 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.1 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.271 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               27.1190978754 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZQW 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.10001903775 
_refine.ls_d_res_low                             23.4974071871 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     44863 
_refine.ls_number_reflns_R_free                  2245 
_refine.ls_number_reflns_R_work                  42618 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.664548807 
_refine.ls_percent_reflns_R_free                 5.00412366538 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.219310861706 
_refine.ls_R_factor_R_free                       0.255082992597 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.217392227749 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.38459695052 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               NONE 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      5WQA 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 24.3230962043 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.251093288554 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.10001903775 
_refine_hist.d_res_low                        23.4974071871 
_refine_hist.number_atoms_solvent             171 
_refine_hist.number_atoms_total               5439 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        5208 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         60 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.00389241540173 ? 5378 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.680191372012   ? 7312 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0387834654414  ? 836  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.00571580321804 ? 956  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 16.3465640051    ? 3264 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.10002 2.1457  . . 132 2644 100.0         . . . . 0.256233992592 . . . . . . . . . . . 0.28207409232  
'X-RAY DIFFRACTION' 2.1457  2.1955  . . 141 2615 100.0         . . . . 0.243873401537 . . . . . . . . . . . 0.282201103233 
'X-RAY DIFFRACTION' 2.1955  2.2504  . . 150 2621 100.0         . . . . 0.250097160191 . . . . . . . . . . . 0.290820786724 
'X-RAY DIFFRACTION' 2.2504  2.3112  . . 126 2660 100.0         . . . . 0.240779926624 . . . . . . . . . . . 0.315291728314 
'X-RAY DIFFRACTION' 2.3112  2.3791  . . 146 2621 100.0         . . . . 0.239117688648 . . . . . . . . . . . 0.31709840206  
'X-RAY DIFFRACTION' 2.3791  2.4558  . . 143 2613 100.0         . . . . 0.237731922633 . . . . . . . . . . . 0.26717309553  
'X-RAY DIFFRACTION' 2.4558  2.5435  . . 147 2658 100.0         . . . . 0.237024259689 . . . . . . . . . . . 0.26066429724  
'X-RAY DIFFRACTION' 2.5435  2.6452  . . 144 2651 100.0         . . . . 0.235510743123 . . . . . . . . . . . 0.297704579073 
'X-RAY DIFFRACTION' 2.6452  2.7654  . . 144 2659 100.0         . . . . 0.231871758088 . . . . . . . . . . . 0.286711671294 
'X-RAY DIFFRACTION' 2.7654  2.911   . . 151 2641 99.9284180387 . . . . 0.231752396436 . . . . . . . . . . . 0.329158483645 
'X-RAY DIFFRACTION' 2.911   3.093   . . 133 2685 99.8582565556 . . . . 0.22745584117  . . . . . . . . . . . 0.259262340066 
'X-RAY DIFFRACTION' 3.093   3.3312  . . 121 2666 99.8209169054 . . . . 0.225350989561 . . . . . . . . . . . 0.279074766448 
'X-RAY DIFFRACTION' 3.3312  3.6653  . . 125 2700 99.4718309859 . . . . 0.217118219787 . . . . . . . . . . . 0.239024777236 
'X-RAY DIFFRACTION' 3.6653  4.1931  . . 145 2692 99.6837666901 . . . . 0.200451278102 . . . . . . . . . . . 0.222432596577 
'X-RAY DIFFRACTION' 4.1931  5.273   . . 164 2699 99.203049203  . . . . 0.17938452066  . . . . . . . . . . . 0.213636528509 
'X-RAY DIFFRACTION' 5.273   23.4974 . . 133 2793 96.9195097714 . . . . 0.1829405794   . . . . . . . . . . . 0.188699329581 
# 
_struct.entry_id                     8ZQW 
_struct.title                        'The crystal structure of PDE4D with isoaurostatin derivatives 2-9' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZQW 
_struct_keywords.text            'Inhibitor, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 2 ? 
G N N 3 ? 
H N N 4 ? 
I N N 5 ? 
J N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PDE4D_HUMAN 
_struct_ref.pdbx_db_accession          Q08499 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIP
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL
LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLS
NPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE
QVEEEAVGEEEESQPEACVIDDRSPD
;
_struct_ref.pdbx_align_begin           303 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZQW A 1 ? 506 ? Q08499 303 ? 808 ? 1 506 
2 1 8ZQW B 1 ? 506 ? Q08499 303 ? 808 ? 1 506 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1930  ? 
1 MORE         -104  ? 
1 'SSA (A^2)'  27470 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 90  ? GLU A 97  ? ASP A 90  GLU A 97  1 ? 8  
HELX_P HELX_P2  AA2 HIS A 105 ? SER A 113 ? HIS A 105 SER A 113 1 ? 9  
HELX_P HELX_P3  AA3 ARG A 116 ? ARG A 129 ? ARG A 116 ARG A 129 1 ? 14 
HELX_P HELX_P4  AA4 ASP A 130 ? PHE A 135 ? ASP A 130 PHE A 135 1 ? 6  
HELX_P HELX_P5  AA5 PRO A 138 ? HIS A 152 ? PRO A 138 HIS A 152 1 ? 15 
HELX_P HELX_P6  AA6 ASN A 161 ? SER A 177 ? ASN A 161 SER A 177 1 ? 17 
HELX_P HELX_P7  AA7 THR A 178 ? GLU A 182 ? THR A 178 GLU A 182 5 ? 5  
HELX_P HELX_P8  AA8 THR A 186 ? HIS A 200 ? THR A 186 HIS A 200 1 ? 15 
HELX_P HELX_P9  AA9 SER A 208 ? THR A 215 ? SER A 208 THR A 215 1 ? 8  
HELX_P HELX_P10 AB1 SER A 217 ? ASN A 224 ? SER A 217 ASN A 224 1 ? 8  
HELX_P HELX_P11 AB2 SER A 227 ? LEU A 240 ? SER A 227 LEU A 240 1 ? 14 
HELX_P HELX_P12 AB3 LEU A 241 ? GLU A 243 ? LEU A 241 GLU A 243 5 ? 3  
HELX_P HELX_P13 AB4 THR A 253 ? ALA A 270 ? THR A 253 ALA A 270 1 ? 18 
HELX_P HELX_P14 AB5 THR A 271 ? SER A 274 ? THR A 271 SER A 274 5 ? 4  
HELX_P HELX_P15 AB6 LYS A 275 ? THR A 289 ? LYS A 275 THR A 289 1 ? 15 
HELX_P HELX_P16 AB7 ASN A 302 ? LEU A 319 ? ASN A 302 LEU A 319 1 ? 18 
HELX_P HELX_P17 AB8 SER A 320 ? LYS A 324 ? SER A 320 LYS A 324 5 ? 5  
HELX_P HELX_P18 AB9 PRO A 325 ? ARG A 350 ? PRO A 325 ARG A 350 1 ? 26 
HELX_P HELX_P19 AC1 ASP A 359 ? ALA A 363 ? ASP A 359 ALA A 363 5 ? 5  
HELX_P HELX_P20 AC2 SER A 364 ? ILE A 376 ? SER A 364 ILE A 376 1 ? 13 
HELX_P HELX_P21 AC3 ILE A 376 ? VAL A 388 ? ILE A 376 VAL A 388 1 ? 13 
HELX_P HELX_P22 AC4 ALA A 392 ? THR A 409 ? ALA A 392 THR A 409 1 ? 18 
HELX_P HELX_P23 AC5 VAL B 91  ? GLU B 97  ? VAL B 91  GLU B 97  1 ? 7  
HELX_P HELX_P24 AC6 HIS B 105 ? SER B 113 ? HIS B 105 SER B 113 1 ? 9  
HELX_P HELX_P25 AC7 ARG B 116 ? ARG B 129 ? ARG B 116 ARG B 129 1 ? 14 
HELX_P HELX_P26 AC8 ASP B 130 ? PHE B 135 ? ASP B 130 PHE B 135 1 ? 6  
HELX_P HELX_P27 AC9 PRO B 138 ? HIS B 152 ? PRO B 138 HIS B 152 1 ? 15 
HELX_P HELX_P28 AD1 ASN B 161 ? LEU B 176 ? ASN B 161 LEU B 176 1 ? 16 
HELX_P HELX_P29 AD2 SER B 177 ? GLU B 182 ? SER B 177 GLU B 182 5 ? 6  
HELX_P HELX_P30 AD3 THR B 186 ? HIS B 200 ? THR B 186 HIS B 200 1 ? 15 
HELX_P HELX_P31 AD4 SER B 208 ? THR B 215 ? SER B 208 THR B 215 1 ? 8  
HELX_P HELX_P32 AD5 SER B 217 ? ASN B 224 ? SER B 217 ASN B 224 1 ? 8  
HELX_P HELX_P33 AD6 SER B 227 ? LEU B 240 ? SER B 227 LEU B 240 1 ? 14 
HELX_P HELX_P34 AD7 LEU B 241 ? GLU B 243 ? LEU B 241 GLU B 243 5 ? 3  
HELX_P HELX_P35 AD8 THR B 253 ? ALA B 270 ? THR B 253 ALA B 270 1 ? 18 
HELX_P HELX_P36 AD9 THR B 271 ? SER B 274 ? THR B 271 SER B 274 5 ? 4  
HELX_P HELX_P37 AE1 LYS B 275 ? THR B 289 ? LYS B 275 THR B 289 1 ? 15 
HELX_P HELX_P38 AE2 ASN B 302 ? LEU B 319 ? ASN B 302 LEU B 319 1 ? 18 
HELX_P HELX_P39 AE3 SER B 320 ? LYS B 324 ? SER B 320 LYS B 324 5 ? 5  
HELX_P HELX_P40 AE4 PRO B 325 ? ARG B 350 ? PRO B 325 ARG B 350 1 ? 26 
HELX_P HELX_P41 AE5 SER B 364 ? ILE B 376 ? SER B 364 ILE B 376 1 ? 13 
HELX_P HELX_P42 AE6 ILE B 376 ? VAL B 388 ? ILE B 376 VAL B 388 1 ? 13 
HELX_P HELX_P43 AE7 ALA B 392 ? THR B 409 ? ALA B 392 THR B 409 1 ? 18 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 164 NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 164 A ZN  601 1_555 ? ? ? ? ? ? ? 2.227 ? ? 
metalc2  metalc ? ? A HIS 200 NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 200 A ZN  601 1_555 ? ? ? ? ? ? ? 2.243 ? ? 
metalc3  metalc ? ? A ASP 201 OD2 ? ? ? 1_555 C ZN  . ZN ? ? A ASP 201 A ZN  601 1_555 ? ? ? ? ? ? ? 2.039 ? ? 
metalc4  metalc ? ? A ASP 201 OD1 ? ? ? 1_555 D MG  . MG ? ? A ASP 201 A MG  602 1_555 ? ? ? ? ? ? ? 2.077 ? ? 
metalc5  metalc ? ? A ASP 318 OD1 ? ? ? 1_555 C ZN  . ZN ? ? A ASP 318 A ZN  601 1_555 ? ? ? ? ? ? ? 2.163 ? ? 
metalc6  metalc ? ? C ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  601 A HOH 740 1_555 ? ? ? ? ? ? ? 2.104 ? ? 
metalc7  metalc ? ? C ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  601 A HOH 753 1_555 ? ? ? ? ? ? ? 2.255 ? ? 
metalc8  metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 724 1_555 ? ? ? ? ? ? ? 2.145 ? ? 
metalc9  metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 740 1_555 ? ? ? ? ? ? ? 1.967 ? ? 
metalc10 metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 741 1_555 ? ? ? ? ? ? ? 2.135 ? ? 
metalc11 metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 777 1_555 ? ? ? ? ? ? ? 2.093 ? ? 
metalc12 metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 802 1_555 ? ? ? ? ? ? ? 2.175 ? ? 
metalc13 metalc ? ? B HIS 164 NE2 ? ? ? 1_555 F ZN  . ZN ? ? B HIS 164 B ZN  601 1_555 ? ? ? ? ? ? ? 2.259 ? ? 
metalc14 metalc ? ? B HIS 200 NE2 ? ? ? 1_555 F ZN  . ZN ? ? B HIS 200 B ZN  601 1_555 ? ? ? ? ? ? ? 2.222 ? ? 
metalc15 metalc ? ? B ASP 201 OD2 ? ? ? 1_555 F ZN  . ZN ? ? B ASP 201 B ZN  601 1_555 ? ? ? ? ? ? ? 2.052 ? ? 
metalc16 metalc ? ? B ASP 201 OD1 ? ? ? 1_555 G MG  . MG ? ? B ASP 201 B MG  602 1_555 ? ? ? ? ? ? ? 2.075 ? ? 
metalc17 metalc ? ? B ASP 318 OD1 ? ? ? 1_555 F ZN  . ZN ? ? B ASP 318 B ZN  601 1_555 ? ? ? ? ? ? ? 2.156 ? ? 
metalc18 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? B ZN  601 B HOH 734 1_555 ? ? ? ? ? ? ? 2.185 ? ? 
metalc19 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? B ZN  601 B HOH 736 1_555 ? ? ? ? ? ? ? 2.066 ? ? 
metalc20 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 710 1_555 ? ? ? ? ? ? ? 2.165 ? ? 
metalc21 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 715 1_555 ? ? ? ? ? ? ? 2.111 ? ? 
metalc22 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 732 1_555 ? ? ? ? ? ? ? 2.268 ? ? 
metalc23 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 736 1_555 ? ? ? ? ? ? ? 2.022 ? ? 
metalc24 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 755 1_555 ? ? ? ? ? ? ? 2.050 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 NE2 ? A HIS 200 ? A HIS 200 ? 1_555 90.8  ? 
2  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD2 ? A ASP 201 ? A ASP 201 ? 1_555 88.8  ? 
3  NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD2 ? A ASP 201 ? A ASP 201 ? 1_555 82.0  ? 
4  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 83.3  ? 
5  NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 89.7  ? 
6  OD2 ? A ASP 201 ? A ASP 201 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 168.6 ? 
7  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 740 ? 1_555 175.7 ? 
8  NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 740 ? 1_555 92.6  ? 
9  OD2 ? A ASP 201 ? A ASP 201 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 740 ? 1_555 89.0  ? 
10 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 740 ? 1_555 99.4  ? 
11 NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 753 ? 1_555 86.7  ? 
12 NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 753 ? 1_555 177.3 ? 
13 OD2 ? A ASP 201 ? A ASP 201 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 753 ? 1_555 99.0  ? 
14 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 753 ? 1_555 88.9  ? 
15 O   ? I HOH .   ? A HOH 740 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 753 ? 1_555 90.0  ? 
16 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 724 ? 1_555 85.4  ? 
17 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 740 ? 1_555 96.3  ? 
18 O   ? I HOH .   ? A HOH 724 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 740 ? 1_555 98.7  ? 
19 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 741 ? 1_555 166.0 ? 
20 O   ? I HOH .   ? A HOH 724 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 741 ? 1_555 83.7  ? 
21 O   ? I HOH .   ? A HOH 740 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 741 ? 1_555 94.0  ? 
22 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 777 ? 1_555 88.3  ? 
23 O   ? I HOH .   ? A HOH 724 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 777 ? 1_555 89.5  ? 
24 O   ? I HOH .   ? A HOH 740 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 777 ? 1_555 170.9 ? 
25 O   ? I HOH .   ? A HOH 741 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 777 ? 1_555 82.8  ? 
26 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 802 ? 1_555 103.7 ? 
27 O   ? I HOH .   ? A HOH 724 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 802 ? 1_555 170.6 ? 
28 O   ? I HOH .   ? A HOH 740 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 802 ? 1_555 82.7  ? 
29 O   ? I HOH .   ? A HOH 741 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 802 ? 1_555 86.9  ? 
30 O   ? I HOH .   ? A HOH 777 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 802 ? 1_555 88.6  ? 
31 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 92.7  ? 
32 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 89.0  ? 
33 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 81.5  ? 
34 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 80.4  ? 
35 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 87.7  ? 
36 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 164.5 ? 
37 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 734 ? 1_555 86.3  ? 
38 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 734 ? 1_555 174.4 ? 
39 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 734 ? 1_555 104.0 ? 
40 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 734 ? 1_555 86.7  ? 
41 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 736 ? 1_555 173.6 ? 
42 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 736 ? 1_555 93.2  ? 
43 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 736 ? 1_555 94.4  ? 
44 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 736 ? 1_555 97.3  ? 
45 O   ? J HOH .   ? B HOH 734 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 736 ? 1_555 87.6  ? 
46 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 710 ? 1_555 162.7 ? 
47 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 715 ? 1_555 85.8  ? 
48 O   ? J HOH .   ? B HOH 710 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 715 ? 1_555 78.2  ? 
49 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 732 ? 1_555 91.0  ? 
50 O   ? J HOH .   ? B HOH 710 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 732 ? 1_555 83.1  ? 
51 O   ? J HOH .   ? B HOH 715 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 732 ? 1_555 91.5  ? 
52 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 736 ? 1_555 93.8  ? 
53 O   ? J HOH .   ? B HOH 710 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 736 ? 1_555 93.7  ? 
54 O   ? J HOH .   ? B HOH 715 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 736 ? 1_555 93.8  ? 
55 O   ? J HOH .   ? B HOH 732 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 736 ? 1_555 173.1 ? 
56 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 755 ? 1_555 103.1 ? 
57 O   ? J HOH .   ? B HOH 710 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 755 ? 1_555 92.7  ? 
58 O   ? J HOH .   ? B HOH 715 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 755 ? 1_555 170.8 ? 
59 O   ? J HOH .   ? B HOH 732 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 755 ? 1_555 85.9  ? 
60 O   ? J HOH .   ? B HOH 736 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 755 ? 1_555 88.2  ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 HIS 389 A . ? HIS 389 A PRO 390 A ? PRO 390 A 1 2.92  
2 HIS 389 B . ? HIS 389 B PRO 390 B ? PRO 390 B 1 -5.91 
# 
_pdbx_entry_details.entry_id                   8ZQW 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OE2 B GLU 338 ? ? NH2 B ARG 342 ? ? 2.10 
2 1 O   A HOH 701 ? ? O   A HOH 803 ? ? 2.14 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    NH2 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    ARG 
_pdbx_validate_symm_contact.auth_seq_id_1     108 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    OD1 
_pdbx_validate_symm_contact.auth_asym_id_2    B 
_pdbx_validate_symm_contact.auth_comp_id_2    ASP 
_pdbx_validate_symm_contact.auth_seq_id_2     401 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   2_454 
_pdbx_validate_symm_contact.dist              2.07 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 161 ? ? -121.40 -167.98 
2 1 ASN A 362 ? ? -152.96 52.86   
3 1 ILE A 376 ? ? -125.96 -63.04  
4 1 ASN B 161 ? ? -128.33 -163.33 
5 1 THR B 178 ? ? -39.28  126.22  
6 1 SER B 295 ? ? -89.64  41.54   
7 1 LEU B 319 ? ? -107.79 42.20   
8 1 ASN B 362 ? ? -157.25 37.78   
9 1 ILE B 376 ? ? -127.15 -58.45  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A ALA 2   ? A ALA 2   
3   1 Y 1 A SER 3   ? A SER 3   
4   1 Y 1 A ASN 4   ? A ASN 4   
5   1 Y 1 A LYS 5   ? A LYS 5   
6   1 Y 1 A PHE 6   ? A PHE 6   
7   1 Y 1 A LYS 7   ? A LYS 7   
8   1 Y 1 A ARG 8   ? A ARG 8   
9   1 Y 1 A MET 9   ? A MET 9   
10  1 Y 1 A LEU 10  ? A LEU 10  
11  1 Y 1 A ASN 11  ? A ASN 11  
12  1 Y 1 A ARG 12  ? A ARG 12  
13  1 Y 1 A GLU 13  ? A GLU 13  
14  1 Y 1 A LEU 14  ? A LEU 14  
15  1 Y 1 A THR 15  ? A THR 15  
16  1 Y 1 A HIS 16  ? A HIS 16  
17  1 Y 1 A LEU 17  ? A LEU 17  
18  1 Y 1 A SER 18  ? A SER 18  
19  1 Y 1 A GLU 19  ? A GLU 19  
20  1 Y 1 A MET 20  ? A MET 20  
21  1 Y 1 A SER 21  ? A SER 21  
22  1 Y 1 A ARG 22  ? A ARG 22  
23  1 Y 1 A SER 23  ? A SER 23  
24  1 Y 1 A GLY 24  ? A GLY 24  
25  1 Y 1 A ASN 25  ? A ASN 25  
26  1 Y 1 A GLN 26  ? A GLN 26  
27  1 Y 1 A VAL 27  ? A VAL 27  
28  1 Y 1 A SER 28  ? A SER 28  
29  1 Y 1 A GLU 29  ? A GLU 29  
30  1 Y 1 A PHE 30  ? A PHE 30  
31  1 Y 1 A ILE 31  ? A ILE 31  
32  1 Y 1 A SER 32  ? A SER 32  
33  1 Y 1 A ASN 33  ? A ASN 33  
34  1 Y 1 A THR 34  ? A THR 34  
35  1 Y 1 A PHE 35  ? A PHE 35  
36  1 Y 1 A LEU 36  ? A LEU 36  
37  1 Y 1 A ASP 37  ? A ASP 37  
38  1 Y 1 A LYS 38  ? A LYS 38  
39  1 Y 1 A GLN 39  ? A GLN 39  
40  1 Y 1 A HIS 40  ? A HIS 40  
41  1 Y 1 A GLU 41  ? A GLU 41  
42  1 Y 1 A VAL 42  ? A VAL 42  
43  1 Y 1 A GLU 43  ? A GLU 43  
44  1 Y 1 A ILE 44  ? A ILE 44  
45  1 Y 1 A PRO 45  ? A PRO 45  
46  1 Y 1 A SER 46  ? A SER 46  
47  1 Y 1 A PRO 47  ? A PRO 47  
48  1 Y 1 A THR 48  ? A THR 48  
49  1 Y 1 A GLN 49  ? A GLN 49  
50  1 Y 1 A LYS 50  ? A LYS 50  
51  1 Y 1 A GLU 51  ? A GLU 51  
52  1 Y 1 A LYS 52  ? A LYS 52  
53  1 Y 1 A GLU 53  ? A GLU 53  
54  1 Y 1 A LYS 54  ? A LYS 54  
55  1 Y 1 A LYS 55  ? A LYS 55  
56  1 Y 1 A LYS 56  ? A LYS 56  
57  1 Y 1 A ARG 57  ? A ARG 57  
58  1 Y 1 A PRO 58  ? A PRO 58  
59  1 Y 1 A MET 59  ? A MET 59  
60  1 Y 1 A SER 60  ? A SER 60  
61  1 Y 1 A GLN 61  ? A GLN 61  
62  1 Y 1 A ILE 62  ? A ILE 62  
63  1 Y 1 A SER 63  ? A SER 63  
64  1 Y 1 A GLY 64  ? A GLY 64  
65  1 Y 1 A VAL 65  ? A VAL 65  
66  1 Y 1 A LYS 66  ? A LYS 66  
67  1 Y 1 A LYS 67  ? A LYS 67  
68  1 Y 1 A LEU 68  ? A LEU 68  
69  1 Y 1 A MET 69  ? A MET 69  
70  1 Y 1 A HIS 70  ? A HIS 70  
71  1 Y 1 A SER 71  ? A SER 71  
72  1 Y 1 A SER 72  ? A SER 72  
73  1 Y 1 A SER 73  ? A SER 73  
74  1 Y 1 A LEU 74  ? A LEU 74  
75  1 Y 1 A THR 75  ? A THR 75  
76  1 Y 1 A ASN 76  ? A ASN 76  
77  1 Y 1 A SER 77  ? A SER 77  
78  1 Y 1 A SER 78  ? A SER 78  
79  1 Y 1 A ILE 79  ? A ILE 79  
80  1 Y 1 A PRO 80  ? A PRO 80  
81  1 Y 1 A ARG 81  ? A ARG 81  
82  1 Y 1 A PHE 82  ? A PHE 82  
83  1 Y 1 A GLY 83  ? A GLY 83  
84  1 Y 1 A VAL 84  ? A VAL 84  
85  1 Y 1 A LYS 85  ? A LYS 85  
86  1 Y 1 A THR 86  ? A THR 86  
87  1 Y 1 A GLU 87  ? A GLU 87  
88  1 Y 1 A GLN 88  ? A GLN 88  
89  1 Y 1 A GLU 89  ? A GLU 89  
90  1 Y 1 A GLN 412 ? A GLN 412 
91  1 Y 1 A SER 413 ? A SER 413 
92  1 Y 1 A PRO 414 ? A PRO 414 
93  1 Y 1 A SER 415 ? A SER 415 
94  1 Y 1 A PRO 416 ? A PRO 416 
95  1 Y 1 A ALA 417 ? A ALA 417 
96  1 Y 1 A PRO 418 ? A PRO 418 
97  1 Y 1 A ASP 419 ? A ASP 419 
98  1 Y 1 A ASP 420 ? A ASP 420 
99  1 Y 1 A PRO 421 ? A PRO 421 
100 1 Y 1 A GLU 422 ? A GLU 422 
101 1 Y 1 A GLU 423 ? A GLU 423 
102 1 Y 1 A GLY 424 ? A GLY 424 
103 1 Y 1 A ARG 425 ? A ARG 425 
104 1 Y 1 A GLN 426 ? A GLN 426 
105 1 Y 1 A GLY 427 ? A GLY 427 
106 1 Y 1 A GLN 428 ? A GLN 428 
107 1 Y 1 A THR 429 ? A THR 429 
108 1 Y 1 A GLU 430 ? A GLU 430 
109 1 Y 1 A LYS 431 ? A LYS 431 
110 1 Y 1 A PHE 432 ? A PHE 432 
111 1 Y 1 A GLN 433 ? A GLN 433 
112 1 Y 1 A PHE 434 ? A PHE 434 
113 1 Y 1 A GLU 435 ? A GLU 435 
114 1 Y 1 A LEU 436 ? A LEU 436 
115 1 Y 1 A THR 437 ? A THR 437 
116 1 Y 1 A LEU 438 ? A LEU 438 
117 1 Y 1 A GLU 439 ? A GLU 439 
118 1 Y 1 A GLU 440 ? A GLU 440 
119 1 Y 1 A ASP 441 ? A ASP 441 
120 1 Y 1 A GLY 442 ? A GLY 442 
121 1 Y 1 A GLU 443 ? A GLU 443 
122 1 Y 1 A SER 444 ? A SER 444 
123 1 Y 1 A ASP 445 ? A ASP 445 
124 1 Y 1 A THR 446 ? A THR 446 
125 1 Y 1 A GLU 447 ? A GLU 447 
126 1 Y 1 A LYS 448 ? A LYS 448 
127 1 Y 1 A ASP 449 ? A ASP 449 
128 1 Y 1 A SER 450 ? A SER 450 
129 1 Y 1 A GLY 451 ? A GLY 451 
130 1 Y 1 A SER 452 ? A SER 452 
131 1 Y 1 A GLN 453 ? A GLN 453 
132 1 Y 1 A VAL 454 ? A VAL 454 
133 1 Y 1 A GLU 455 ? A GLU 455 
134 1 Y 1 A GLU 456 ? A GLU 456 
135 1 Y 1 A ASP 457 ? A ASP 457 
136 1 Y 1 A THR 458 ? A THR 458 
137 1 Y 1 A SER 459 ? A SER 459 
138 1 Y 1 A CYS 460 ? A CYS 460 
139 1 Y 1 A SER 461 ? A SER 461 
140 1 Y 1 A ASP 462 ? A ASP 462 
141 1 Y 1 A SER 463 ? A SER 463 
142 1 Y 1 A LYS 464 ? A LYS 464 
143 1 Y 1 A THR 465 ? A THR 465 
144 1 Y 1 A LEU 466 ? A LEU 466 
145 1 Y 1 A CYS 467 ? A CYS 467 
146 1 Y 1 A THR 468 ? A THR 468 
147 1 Y 1 A GLN 469 ? A GLN 469 
148 1 Y 1 A ASP 470 ? A ASP 470 
149 1 Y 1 A SER 471 ? A SER 471 
150 1 Y 1 A GLU 472 ? A GLU 472 
151 1 Y 1 A SER 473 ? A SER 473 
152 1 Y 1 A THR 474 ? A THR 474 
153 1 Y 1 A GLU 475 ? A GLU 475 
154 1 Y 1 A ILE 476 ? A ILE 476 
155 1 Y 1 A PRO 477 ? A PRO 477 
156 1 Y 1 A LEU 478 ? A LEU 478 
157 1 Y 1 A ASP 479 ? A ASP 479 
158 1 Y 1 A GLU 480 ? A GLU 480 
159 1 Y 1 A GLN 481 ? A GLN 481 
160 1 Y 1 A VAL 482 ? A VAL 482 
161 1 Y 1 A GLU 483 ? A GLU 483 
162 1 Y 1 A GLU 484 ? A GLU 484 
163 1 Y 1 A GLU 485 ? A GLU 485 
164 1 Y 1 A ALA 486 ? A ALA 486 
165 1 Y 1 A VAL 487 ? A VAL 487 
166 1 Y 1 A GLY 488 ? A GLY 488 
167 1 Y 1 A GLU 489 ? A GLU 489 
168 1 Y 1 A GLU 490 ? A GLU 490 
169 1 Y 1 A GLU 491 ? A GLU 491 
170 1 Y 1 A GLU 492 ? A GLU 492 
171 1 Y 1 A SER 493 ? A SER 493 
172 1 Y 1 A GLN 494 ? A GLN 494 
173 1 Y 1 A PRO 495 ? A PRO 495 
174 1 Y 1 A GLU 496 ? A GLU 496 
175 1 Y 1 A ALA 497 ? A ALA 497 
176 1 Y 1 A CYS 498 ? A CYS 498 
177 1 Y 1 A VAL 499 ? A VAL 499 
178 1 Y 1 A ILE 500 ? A ILE 500 
179 1 Y 1 A ASP 501 ? A ASP 501 
180 1 Y 1 A ASP 502 ? A ASP 502 
181 1 Y 1 A ARG 503 ? A ARG 503 
182 1 Y 1 A SER 504 ? A SER 504 
183 1 Y 1 A PRO 505 ? A PRO 505 
184 1 Y 1 A ASP 506 ? A ASP 506 
185 1 Y 1 B MET 1   ? B MET 1   
186 1 Y 1 B ALA 2   ? B ALA 2   
187 1 Y 1 B SER 3   ? B SER 3   
188 1 Y 1 B ASN 4   ? B ASN 4   
189 1 Y 1 B LYS 5   ? B LYS 5   
190 1 Y 1 B PHE 6   ? B PHE 6   
191 1 Y 1 B LYS 7   ? B LYS 7   
192 1 Y 1 B ARG 8   ? B ARG 8   
193 1 Y 1 B MET 9   ? B MET 9   
194 1 Y 1 B LEU 10  ? B LEU 10  
195 1 Y 1 B ASN 11  ? B ASN 11  
196 1 Y 1 B ARG 12  ? B ARG 12  
197 1 Y 1 B GLU 13  ? B GLU 13  
198 1 Y 1 B LEU 14  ? B LEU 14  
199 1 Y 1 B THR 15  ? B THR 15  
200 1 Y 1 B HIS 16  ? B HIS 16  
201 1 Y 1 B LEU 17  ? B LEU 17  
202 1 Y 1 B SER 18  ? B SER 18  
203 1 Y 1 B GLU 19  ? B GLU 19  
204 1 Y 1 B MET 20  ? B MET 20  
205 1 Y 1 B SER 21  ? B SER 21  
206 1 Y 1 B ARG 22  ? B ARG 22  
207 1 Y 1 B SER 23  ? B SER 23  
208 1 Y 1 B GLY 24  ? B GLY 24  
209 1 Y 1 B ASN 25  ? B ASN 25  
210 1 Y 1 B GLN 26  ? B GLN 26  
211 1 Y 1 B VAL 27  ? B VAL 27  
212 1 Y 1 B SER 28  ? B SER 28  
213 1 Y 1 B GLU 29  ? B GLU 29  
214 1 Y 1 B PHE 30  ? B PHE 30  
215 1 Y 1 B ILE 31  ? B ILE 31  
216 1 Y 1 B SER 32  ? B SER 32  
217 1 Y 1 B ASN 33  ? B ASN 33  
218 1 Y 1 B THR 34  ? B THR 34  
219 1 Y 1 B PHE 35  ? B PHE 35  
220 1 Y 1 B LEU 36  ? B LEU 36  
221 1 Y 1 B ASP 37  ? B ASP 37  
222 1 Y 1 B LYS 38  ? B LYS 38  
223 1 Y 1 B GLN 39  ? B GLN 39  
224 1 Y 1 B HIS 40  ? B HIS 40  
225 1 Y 1 B GLU 41  ? B GLU 41  
226 1 Y 1 B VAL 42  ? B VAL 42  
227 1 Y 1 B GLU 43  ? B GLU 43  
228 1 Y 1 B ILE 44  ? B ILE 44  
229 1 Y 1 B PRO 45  ? B PRO 45  
230 1 Y 1 B SER 46  ? B SER 46  
231 1 Y 1 B PRO 47  ? B PRO 47  
232 1 Y 1 B THR 48  ? B THR 48  
233 1 Y 1 B GLN 49  ? B GLN 49  
234 1 Y 1 B LYS 50  ? B LYS 50  
235 1 Y 1 B GLU 51  ? B GLU 51  
236 1 Y 1 B LYS 52  ? B LYS 52  
237 1 Y 1 B GLU 53  ? B GLU 53  
238 1 Y 1 B LYS 54  ? B LYS 54  
239 1 Y 1 B LYS 55  ? B LYS 55  
240 1 Y 1 B LYS 56  ? B LYS 56  
241 1 Y 1 B ARG 57  ? B ARG 57  
242 1 Y 1 B PRO 58  ? B PRO 58  
243 1 Y 1 B MET 59  ? B MET 59  
244 1 Y 1 B SER 60  ? B SER 60  
245 1 Y 1 B GLN 61  ? B GLN 61  
246 1 Y 1 B ILE 62  ? B ILE 62  
247 1 Y 1 B SER 63  ? B SER 63  
248 1 Y 1 B GLY 64  ? B GLY 64  
249 1 Y 1 B VAL 65  ? B VAL 65  
250 1 Y 1 B LYS 66  ? B LYS 66  
251 1 Y 1 B LYS 67  ? B LYS 67  
252 1 Y 1 B LEU 68  ? B LEU 68  
253 1 Y 1 B MET 69  ? B MET 69  
254 1 Y 1 B HIS 70  ? B HIS 70  
255 1 Y 1 B SER 71  ? B SER 71  
256 1 Y 1 B SER 72  ? B SER 72  
257 1 Y 1 B SER 73  ? B SER 73  
258 1 Y 1 B LEU 74  ? B LEU 74  
259 1 Y 1 B THR 75  ? B THR 75  
260 1 Y 1 B ASN 76  ? B ASN 76  
261 1 Y 1 B SER 77  ? B SER 77  
262 1 Y 1 B SER 78  ? B SER 78  
263 1 Y 1 B ILE 79  ? B ILE 79  
264 1 Y 1 B PRO 80  ? B PRO 80  
265 1 Y 1 B ARG 81  ? B ARG 81  
266 1 Y 1 B PHE 82  ? B PHE 82  
267 1 Y 1 B GLY 83  ? B GLY 83  
268 1 Y 1 B VAL 84  ? B VAL 84  
269 1 Y 1 B LYS 85  ? B LYS 85  
270 1 Y 1 B THR 86  ? B THR 86  
271 1 Y 1 B GLU 87  ? B GLU 87  
272 1 Y 1 B GLN 88  ? B GLN 88  
273 1 Y 1 B GLU 89  ? B GLU 89  
274 1 Y 1 B GLN 412 ? B GLN 412 
275 1 Y 1 B SER 413 ? B SER 413 
276 1 Y 1 B PRO 414 ? B PRO 414 
277 1 Y 1 B SER 415 ? B SER 415 
278 1 Y 1 B PRO 416 ? B PRO 416 
279 1 Y 1 B ALA 417 ? B ALA 417 
280 1 Y 1 B PRO 418 ? B PRO 418 
281 1 Y 1 B ASP 419 ? B ASP 419 
282 1 Y 1 B ASP 420 ? B ASP 420 
283 1 Y 1 B PRO 421 ? B PRO 421 
284 1 Y 1 B GLU 422 ? B GLU 422 
285 1 Y 1 B GLU 423 ? B GLU 423 
286 1 Y 1 B GLY 424 ? B GLY 424 
287 1 Y 1 B ARG 425 ? B ARG 425 
288 1 Y 1 B GLN 426 ? B GLN 426 
289 1 Y 1 B GLY 427 ? B GLY 427 
290 1 Y 1 B GLN 428 ? B GLN 428 
291 1 Y 1 B THR 429 ? B THR 429 
292 1 Y 1 B GLU 430 ? B GLU 430 
293 1 Y 1 B LYS 431 ? B LYS 431 
294 1 Y 1 B PHE 432 ? B PHE 432 
295 1 Y 1 B GLN 433 ? B GLN 433 
296 1 Y 1 B PHE 434 ? B PHE 434 
297 1 Y 1 B GLU 435 ? B GLU 435 
298 1 Y 1 B LEU 436 ? B LEU 436 
299 1 Y 1 B THR 437 ? B THR 437 
300 1 Y 1 B LEU 438 ? B LEU 438 
301 1 Y 1 B GLU 439 ? B GLU 439 
302 1 Y 1 B GLU 440 ? B GLU 440 
303 1 Y 1 B ASP 441 ? B ASP 441 
304 1 Y 1 B GLY 442 ? B GLY 442 
305 1 Y 1 B GLU 443 ? B GLU 443 
306 1 Y 1 B SER 444 ? B SER 444 
307 1 Y 1 B ASP 445 ? B ASP 445 
308 1 Y 1 B THR 446 ? B THR 446 
309 1 Y 1 B GLU 447 ? B GLU 447 
310 1 Y 1 B LYS 448 ? B LYS 448 
311 1 Y 1 B ASP 449 ? B ASP 449 
312 1 Y 1 B SER 450 ? B SER 450 
313 1 Y 1 B GLY 451 ? B GLY 451 
314 1 Y 1 B SER 452 ? B SER 452 
315 1 Y 1 B GLN 453 ? B GLN 453 
316 1 Y 1 B VAL 454 ? B VAL 454 
317 1 Y 1 B GLU 455 ? B GLU 455 
318 1 Y 1 B GLU 456 ? B GLU 456 
319 1 Y 1 B ASP 457 ? B ASP 457 
320 1 Y 1 B THR 458 ? B THR 458 
321 1 Y 1 B SER 459 ? B SER 459 
322 1 Y 1 B CYS 460 ? B CYS 460 
323 1 Y 1 B SER 461 ? B SER 461 
324 1 Y 1 B ASP 462 ? B ASP 462 
325 1 Y 1 B SER 463 ? B SER 463 
326 1 Y 1 B LYS 464 ? B LYS 464 
327 1 Y 1 B THR 465 ? B THR 465 
328 1 Y 1 B LEU 466 ? B LEU 466 
329 1 Y 1 B CYS 467 ? B CYS 467 
330 1 Y 1 B THR 468 ? B THR 468 
331 1 Y 1 B GLN 469 ? B GLN 469 
332 1 Y 1 B ASP 470 ? B ASP 470 
333 1 Y 1 B SER 471 ? B SER 471 
334 1 Y 1 B GLU 472 ? B GLU 472 
335 1 Y 1 B SER 473 ? B SER 473 
336 1 Y 1 B THR 474 ? B THR 474 
337 1 Y 1 B GLU 475 ? B GLU 475 
338 1 Y 1 B ILE 476 ? B ILE 476 
339 1 Y 1 B PRO 477 ? B PRO 477 
340 1 Y 1 B LEU 478 ? B LEU 478 
341 1 Y 1 B ASP 479 ? B ASP 479 
342 1 Y 1 B GLU 480 ? B GLU 480 
343 1 Y 1 B GLN 481 ? B GLN 481 
344 1 Y 1 B VAL 482 ? B VAL 482 
345 1 Y 1 B GLU 483 ? B GLU 483 
346 1 Y 1 B GLU 484 ? B GLU 484 
347 1 Y 1 B GLU 485 ? B GLU 485 
348 1 Y 1 B ALA 486 ? B ALA 486 
349 1 Y 1 B VAL 487 ? B VAL 487 
350 1 Y 1 B GLY 488 ? B GLY 488 
351 1 Y 1 B GLU 489 ? B GLU 489 
352 1 Y 1 B GLU 490 ? B GLU 490 
353 1 Y 1 B GLU 491 ? B GLU 491 
354 1 Y 1 B GLU 492 ? B GLU 492 
355 1 Y 1 B SER 493 ? B SER 493 
356 1 Y 1 B GLN 494 ? B GLN 494 
357 1 Y 1 B PRO 495 ? B PRO 495 
358 1 Y 1 B GLU 496 ? B GLU 496 
359 1 Y 1 B ALA 497 ? B ALA 497 
360 1 Y 1 B CYS 498 ? B CYS 498 
361 1 Y 1 B VAL 499 ? B VAL 499 
362 1 Y 1 B ILE 500 ? B ILE 500 
363 1 Y 1 B ASP 501 ? B ASP 501 
364 1 Y 1 B ASP 502 ? B ASP 502 
365 1 Y 1 B ARG 503 ? B ARG 503 
366 1 Y 1 B SER 504 ? B SER 504 
367 1 Y 1 B PRO 505 ? B PRO 505 
368 1 Y 1 B ASP 506 ? B ASP 506 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1D8Q C4   C  Y N 1   
A1D8Q C5   C  Y N 2   
A1D8Q C6   C  Y N 3   
A1D8Q C3   C  Y N 4   
A1D8Q C2   C  Y N 5   
A1D8Q C1   C  Y N 6   
A1D8Q C7   C  N N 7   
A1D8Q C8   C  N N 8   
A1D8Q N9   N  N N 9   
A1D8Q O10  O  N N 10  
A1D8Q C11  C  N N 11  
A1D8Q O12  O  N N 12  
A1D8Q C13  C  Y N 13  
A1D8Q C14  C  Y N 14  
A1D8Q C15  C  Y N 15  
A1D8Q C16  C  Y N 16  
A1D8Q C17  C  Y N 17  
A1D8Q C18  C  Y N 18  
A1D8Q O19  O  N N 19  
A1D8Q O20  O  N N 20  
A1D8Q C21  C  N N 21  
A1D8Q F22  F  N N 22  
A1D8Q F23  F  N N 23  
A1D8Q C24  C  N N 24  
A1D8Q C25  C  N N 25  
A1D8Q C26  C  N N 26  
A1D8Q C27  C  N N 27  
A1D8Q C28  C  N N 28  
A1D8Q H3   H  N N 29  
A1D8Q H2   H  N N 30  
A1D8Q H1   H  N N 31  
A1D8Q H4   H  N N 32  
A1D8Q H5   H  N N 33  
A1D8Q H6   H  N N 34  
A1D8Q H7   H  N N 35  
A1D8Q H8   H  N N 36  
A1D8Q H9   H  N N 37  
A1D8Q H10  H  N N 38  
A1D8Q H11  H  N N 39  
A1D8Q H12  H  N N 40  
A1D8Q H13  H  N N 41  
A1D8Q H14  H  N N 42  
A1D8Q H15  H  N N 43  
A1D8Q H16  H  N N 44  
A1D8Q H17  H  N N 45  
A1D8Q H18  H  N N 46  
A1D8Q H19  H  N N 47  
ALA   N    N  N N 48  
ALA   CA   C  N S 49  
ALA   C    C  N N 50  
ALA   O    O  N N 51  
ALA   CB   C  N N 52  
ALA   OXT  O  N N 53  
ALA   H    H  N N 54  
ALA   H2   H  N N 55  
ALA   HA   H  N N 56  
ALA   HB1  H  N N 57  
ALA   HB2  H  N N 58  
ALA   HB3  H  N N 59  
ALA   HXT  H  N N 60  
ARG   N    N  N N 61  
ARG   CA   C  N S 62  
ARG   C    C  N N 63  
ARG   O    O  N N 64  
ARG   CB   C  N N 65  
ARG   CG   C  N N 66  
ARG   CD   C  N N 67  
ARG   NE   N  N N 68  
ARG   CZ   C  N N 69  
ARG   NH1  N  N N 70  
ARG   NH2  N  N N 71  
ARG   OXT  O  N N 72  
ARG   H    H  N N 73  
ARG   H2   H  N N 74  
ARG   HA   H  N N 75  
ARG   HB2  H  N N 76  
ARG   HB3  H  N N 77  
ARG   HG2  H  N N 78  
ARG   HG3  H  N N 79  
ARG   HD2  H  N N 80  
ARG   HD3  H  N N 81  
ARG   HE   H  N N 82  
ARG   HH11 H  N N 83  
ARG   HH12 H  N N 84  
ARG   HH21 H  N N 85  
ARG   HH22 H  N N 86  
ARG   HXT  H  N N 87  
ASN   N    N  N N 88  
ASN   CA   C  N S 89  
ASN   C    C  N N 90  
ASN   O    O  N N 91  
ASN   CB   C  N N 92  
ASN   CG   C  N N 93  
ASN   OD1  O  N N 94  
ASN   ND2  N  N N 95  
ASN   OXT  O  N N 96  
ASN   H    H  N N 97  
ASN   H2   H  N N 98  
ASN   HA   H  N N 99  
ASN   HB2  H  N N 100 
ASN   HB3  H  N N 101 
ASN   HD21 H  N N 102 
ASN   HD22 H  N N 103 
ASN   HXT  H  N N 104 
ASP   N    N  N N 105 
ASP   CA   C  N S 106 
ASP   C    C  N N 107 
ASP   O    O  N N 108 
ASP   CB   C  N N 109 
ASP   CG   C  N N 110 
ASP   OD1  O  N N 111 
ASP   OD2  O  N N 112 
ASP   OXT  O  N N 113 
ASP   H    H  N N 114 
ASP   H2   H  N N 115 
ASP   HA   H  N N 116 
ASP   HB2  H  N N 117 
ASP   HB3  H  N N 118 
ASP   HD2  H  N N 119 
ASP   HXT  H  N N 120 
CYS   N    N  N N 121 
CYS   CA   C  N R 122 
CYS   C    C  N N 123 
CYS   O    O  N N 124 
CYS   CB   C  N N 125 
CYS   SG   S  N N 126 
CYS   OXT  O  N N 127 
CYS   H    H  N N 128 
CYS   H2   H  N N 129 
CYS   HA   H  N N 130 
CYS   HB2  H  N N 131 
CYS   HB3  H  N N 132 
CYS   HG   H  N N 133 
CYS   HXT  H  N N 134 
GLN   N    N  N N 135 
GLN   CA   C  N S 136 
GLN   C    C  N N 137 
GLN   O    O  N N 138 
GLN   CB   C  N N 139 
GLN   CG   C  N N 140 
GLN   CD   C  N N 141 
GLN   OE1  O  N N 142 
GLN   NE2  N  N N 143 
GLN   OXT  O  N N 144 
GLN   H    H  N N 145 
GLN   H2   H  N N 146 
GLN   HA   H  N N 147 
GLN   HB2  H  N N 148 
GLN   HB3  H  N N 149 
GLN   HG2  H  N N 150 
GLN   HG3  H  N N 151 
GLN   HE21 H  N N 152 
GLN   HE22 H  N N 153 
GLN   HXT  H  N N 154 
GLU   N    N  N N 155 
GLU   CA   C  N S 156 
GLU   C    C  N N 157 
GLU   O    O  N N 158 
GLU   CB   C  N N 159 
GLU   CG   C  N N 160 
GLU   CD   C  N N 161 
GLU   OE1  O  N N 162 
GLU   OE2  O  N N 163 
GLU   OXT  O  N N 164 
GLU   H    H  N N 165 
GLU   H2   H  N N 166 
GLU   HA   H  N N 167 
GLU   HB2  H  N N 168 
GLU   HB3  H  N N 169 
GLU   HG2  H  N N 170 
GLU   HG3  H  N N 171 
GLU   HE2  H  N N 172 
GLU   HXT  H  N N 173 
GLY   N    N  N N 174 
GLY   CA   C  N N 175 
GLY   C    C  N N 176 
GLY   O    O  N N 177 
GLY   OXT  O  N N 178 
GLY   H    H  N N 179 
GLY   H2   H  N N 180 
GLY   HA2  H  N N 181 
GLY   HA3  H  N N 182 
GLY   HXT  H  N N 183 
HIS   N    N  N N 184 
HIS   CA   C  N S 185 
HIS   C    C  N N 186 
HIS   O    O  N N 187 
HIS   CB   C  N N 188 
HIS   CG   C  Y N 189 
HIS   ND1  N  Y N 190 
HIS   CD2  C  Y N 191 
HIS   CE1  C  Y N 192 
HIS   NE2  N  Y N 193 
HIS   OXT  O  N N 194 
HIS   H    H  N N 195 
HIS   H2   H  N N 196 
HIS   HA   H  N N 197 
HIS   HB2  H  N N 198 
HIS   HB3  H  N N 199 
HIS   HD1  H  N N 200 
HIS   HD2  H  N N 201 
HIS   HE1  H  N N 202 
HIS   HE2  H  N N 203 
HIS   HXT  H  N N 204 
HOH   O    O  N N 205 
HOH   H1   H  N N 206 
HOH   H2   H  N N 207 
ILE   N    N  N N 208 
ILE   CA   C  N S 209 
ILE   C    C  N N 210 
ILE   O    O  N N 211 
ILE   CB   C  N S 212 
ILE   CG1  C  N N 213 
ILE   CG2  C  N N 214 
ILE   CD1  C  N N 215 
ILE   OXT  O  N N 216 
ILE   H    H  N N 217 
ILE   H2   H  N N 218 
ILE   HA   H  N N 219 
ILE   HB   H  N N 220 
ILE   HG12 H  N N 221 
ILE   HG13 H  N N 222 
ILE   HG21 H  N N 223 
ILE   HG22 H  N N 224 
ILE   HG23 H  N N 225 
ILE   HD11 H  N N 226 
ILE   HD12 H  N N 227 
ILE   HD13 H  N N 228 
ILE   HXT  H  N N 229 
LEU   N    N  N N 230 
LEU   CA   C  N S 231 
LEU   C    C  N N 232 
LEU   O    O  N N 233 
LEU   CB   C  N N 234 
LEU   CG   C  N N 235 
LEU   CD1  C  N N 236 
LEU   CD2  C  N N 237 
LEU   OXT  O  N N 238 
LEU   H    H  N N 239 
LEU   H2   H  N N 240 
LEU   HA   H  N N 241 
LEU   HB2  H  N N 242 
LEU   HB3  H  N N 243 
LEU   HG   H  N N 244 
LEU   HD11 H  N N 245 
LEU   HD12 H  N N 246 
LEU   HD13 H  N N 247 
LEU   HD21 H  N N 248 
LEU   HD22 H  N N 249 
LEU   HD23 H  N N 250 
LEU   HXT  H  N N 251 
LYS   N    N  N N 252 
LYS   CA   C  N S 253 
LYS   C    C  N N 254 
LYS   O    O  N N 255 
LYS   CB   C  N N 256 
LYS   CG   C  N N 257 
LYS   CD   C  N N 258 
LYS   CE   C  N N 259 
LYS   NZ   N  N N 260 
LYS   OXT  O  N N 261 
LYS   H    H  N N 262 
LYS   H2   H  N N 263 
LYS   HA   H  N N 264 
LYS   HB2  H  N N 265 
LYS   HB3  H  N N 266 
LYS   HG2  H  N N 267 
LYS   HG3  H  N N 268 
LYS   HD2  H  N N 269 
LYS   HD3  H  N N 270 
LYS   HE2  H  N N 271 
LYS   HE3  H  N N 272 
LYS   HZ1  H  N N 273 
LYS   HZ2  H  N N 274 
LYS   HZ3  H  N N 275 
LYS   HXT  H  N N 276 
MET   N    N  N N 277 
MET   CA   C  N S 278 
MET   C    C  N N 279 
MET   O    O  N N 280 
MET   CB   C  N N 281 
MET   CG   C  N N 282 
MET   SD   S  N N 283 
MET   CE   C  N N 284 
MET   OXT  O  N N 285 
MET   H    H  N N 286 
MET   H2   H  N N 287 
MET   HA   H  N N 288 
MET   HB2  H  N N 289 
MET   HB3  H  N N 290 
MET   HG2  H  N N 291 
MET   HG3  H  N N 292 
MET   HE1  H  N N 293 
MET   HE2  H  N N 294 
MET   HE3  H  N N 295 
MET   HXT  H  N N 296 
MG    MG   MG N N 297 
PHE   N    N  N N 298 
PHE   CA   C  N S 299 
PHE   C    C  N N 300 
PHE   O    O  N N 301 
PHE   CB   C  N N 302 
PHE   CG   C  Y N 303 
PHE   CD1  C  Y N 304 
PHE   CD2  C  Y N 305 
PHE   CE1  C  Y N 306 
PHE   CE2  C  Y N 307 
PHE   CZ   C  Y N 308 
PHE   OXT  O  N N 309 
PHE   H    H  N N 310 
PHE   H2   H  N N 311 
PHE   HA   H  N N 312 
PHE   HB2  H  N N 313 
PHE   HB3  H  N N 314 
PHE   HD1  H  N N 315 
PHE   HD2  H  N N 316 
PHE   HE1  H  N N 317 
PHE   HE2  H  N N 318 
PHE   HZ   H  N N 319 
PHE   HXT  H  N N 320 
PRO   N    N  N N 321 
PRO   CA   C  N S 322 
PRO   C    C  N N 323 
PRO   O    O  N N 324 
PRO   CB   C  N N 325 
PRO   CG   C  N N 326 
PRO   CD   C  N N 327 
PRO   OXT  O  N N 328 
PRO   H    H  N N 329 
PRO   HA   H  N N 330 
PRO   HB2  H  N N 331 
PRO   HB3  H  N N 332 
PRO   HG2  H  N N 333 
PRO   HG3  H  N N 334 
PRO   HD2  H  N N 335 
PRO   HD3  H  N N 336 
PRO   HXT  H  N N 337 
SER   N    N  N N 338 
SER   CA   C  N S 339 
SER   C    C  N N 340 
SER   O    O  N N 341 
SER   CB   C  N N 342 
SER   OG   O  N N 343 
SER   OXT  O  N N 344 
SER   H    H  N N 345 
SER   H2   H  N N 346 
SER   HA   H  N N 347 
SER   HB2  H  N N 348 
SER   HB3  H  N N 349 
SER   HG   H  N N 350 
SER   HXT  H  N N 351 
THR   N    N  N N 352 
THR   CA   C  N S 353 
THR   C    C  N N 354 
THR   O    O  N N 355 
THR   CB   C  N R 356 
THR   OG1  O  N N 357 
THR   CG2  C  N N 358 
THR   OXT  O  N N 359 
THR   H    H  N N 360 
THR   H2   H  N N 361 
THR   HA   H  N N 362 
THR   HB   H  N N 363 
THR   HG1  H  N N 364 
THR   HG21 H  N N 365 
THR   HG22 H  N N 366 
THR   HG23 H  N N 367 
THR   HXT  H  N N 368 
TRP   N    N  N N 369 
TRP   CA   C  N S 370 
TRP   C    C  N N 371 
TRP   O    O  N N 372 
TRP   CB   C  N N 373 
TRP   CG   C  Y N 374 
TRP   CD1  C  Y N 375 
TRP   CD2  C  Y N 376 
TRP   NE1  N  Y N 377 
TRP   CE2  C  Y N 378 
TRP   CE3  C  Y N 379 
TRP   CZ2  C  Y N 380 
TRP   CZ3  C  Y N 381 
TRP   CH2  C  Y N 382 
TRP   OXT  O  N N 383 
TRP   H    H  N N 384 
TRP   H2   H  N N 385 
TRP   HA   H  N N 386 
TRP   HB2  H  N N 387 
TRP   HB3  H  N N 388 
TRP   HD1  H  N N 389 
TRP   HE1  H  N N 390 
TRP   HE3  H  N N 391 
TRP   HZ2  H  N N 392 
TRP   HZ3  H  N N 393 
TRP   HH2  H  N N 394 
TRP   HXT  H  N N 395 
TYR   N    N  N N 396 
TYR   CA   C  N S 397 
TYR   C    C  N N 398 
TYR   O    O  N N 399 
TYR   CB   C  N N 400 
TYR   CG   C  Y N 401 
TYR   CD1  C  Y N 402 
TYR   CD2  C  Y N 403 
TYR   CE1  C  Y N 404 
TYR   CE2  C  Y N 405 
TYR   CZ   C  Y N 406 
TYR   OH   O  N N 407 
TYR   OXT  O  N N 408 
TYR   H    H  N N 409 
TYR   H2   H  N N 410 
TYR   HA   H  N N 411 
TYR   HB2  H  N N 412 
TYR   HB3  H  N N 413 
TYR   HD1  H  N N 414 
TYR   HD2  H  N N 415 
TYR   HE1  H  N N 416 
TYR   HE2  H  N N 417 
TYR   HH   H  N N 418 
TYR   HXT  H  N N 419 
VAL   N    N  N N 420 
VAL   CA   C  N S 421 
VAL   C    C  N N 422 
VAL   O    O  N N 423 
VAL   CB   C  N N 424 
VAL   CG1  C  N N 425 
VAL   CG2  C  N N 426 
VAL   OXT  O  N N 427 
VAL   H    H  N N 428 
VAL   H2   H  N N 429 
VAL   HA   H  N N 430 
VAL   HB   H  N N 431 
VAL   HG11 H  N N 432 
VAL   HG12 H  N N 433 
VAL   HG13 H  N N 434 
VAL   HG21 H  N N 435 
VAL   HG22 H  N N 436 
VAL   HG23 H  N N 437 
VAL   HXT  H  N N 438 
ZN    ZN   ZN N N 439 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1D8Q C1  C2   doub Y N 1   
A1D8Q C2  C3   sing Y N 2   
A1D8Q C3  C4   doub Y N 3   
A1D8Q C4  C5   sing Y N 4   
A1D8Q C5  C6   doub Y N 5   
A1D8Q C6  C1   sing Y N 6   
A1D8Q C5  C7   sing N N 7   
A1D8Q C7  C8   sing N N 8   
A1D8Q C8  N9   sing N N 9   
A1D8Q N9  C6   sing N N 10  
A1D8Q C8  O10  doub N N 11  
A1D8Q C7  C11  doub N Z 12  
A1D8Q C2  O12  sing N N 13  
A1D8Q C11 C13  sing N N 14  
A1D8Q C13 C14  doub Y N 15  
A1D8Q C14 C15  sing Y N 16  
A1D8Q C15 C16  doub Y N 17  
A1D8Q C16 C17  sing Y N 18  
A1D8Q C17 C18  doub Y N 19  
A1D8Q C18 C13  sing Y N 20  
A1D8Q C16 O19  sing N N 21  
A1D8Q C15 O20  sing N N 22  
A1D8Q O19 C21  sing N N 23  
A1D8Q C21 F22  sing N N 24  
A1D8Q C21 F23  sing N N 25  
A1D8Q O20 C24  sing N N 26  
A1D8Q C24 C25  sing N N 27  
A1D8Q C25 C26  sing N N 28  
A1D8Q C26 C27  sing N N 29  
A1D8Q C27 C28  sing N N 30  
A1D8Q C28 C24  sing N N 31  
A1D8Q C4  H3   sing N N 32  
A1D8Q C3  H2   sing N N 33  
A1D8Q C1  H1   sing N N 34  
A1D8Q N9  H4   sing N N 35  
A1D8Q C11 H5   sing N N 36  
A1D8Q O12 H6   sing N N 37  
A1D8Q C14 H7   sing N N 38  
A1D8Q C17 H8   sing N N 39  
A1D8Q C18 H9   sing N N 40  
A1D8Q C21 H10  sing N N 41  
A1D8Q C24 H11  sing N N 42  
A1D8Q C25 H12  sing N N 43  
A1D8Q C25 H13  sing N N 44  
A1D8Q C26 H14  sing N N 45  
A1D8Q C26 H15  sing N N 46  
A1D8Q C27 H16  sing N N 47  
A1D8Q C27 H17  sing N N 48  
A1D8Q C28 H18  sing N N 49  
A1D8Q C28 H19  sing N N 50  
ALA   N   CA   sing N N 51  
ALA   N   H    sing N N 52  
ALA   N   H2   sing N N 53  
ALA   CA  C    sing N N 54  
ALA   CA  CB   sing N N 55  
ALA   CA  HA   sing N N 56  
ALA   C   O    doub N N 57  
ALA   C   OXT  sing N N 58  
ALA   CB  HB1  sing N N 59  
ALA   CB  HB2  sing N N 60  
ALA   CB  HB3  sing N N 61  
ALA   OXT HXT  sing N N 62  
ARG   N   CA   sing N N 63  
ARG   N   H    sing N N 64  
ARG   N   H2   sing N N 65  
ARG   CA  C    sing N N 66  
ARG   CA  CB   sing N N 67  
ARG   CA  HA   sing N N 68  
ARG   C   O    doub N N 69  
ARG   C   OXT  sing N N 70  
ARG   CB  CG   sing N N 71  
ARG   CB  HB2  sing N N 72  
ARG   CB  HB3  sing N N 73  
ARG   CG  CD   sing N N 74  
ARG   CG  HG2  sing N N 75  
ARG   CG  HG3  sing N N 76  
ARG   CD  NE   sing N N 77  
ARG   CD  HD2  sing N N 78  
ARG   CD  HD3  sing N N 79  
ARG   NE  CZ   sing N N 80  
ARG   NE  HE   sing N N 81  
ARG   CZ  NH1  sing N N 82  
ARG   CZ  NH2  doub N N 83  
ARG   NH1 HH11 sing N N 84  
ARG   NH1 HH12 sing N N 85  
ARG   NH2 HH21 sing N N 86  
ARG   NH2 HH22 sing N N 87  
ARG   OXT HXT  sing N N 88  
ASN   N   CA   sing N N 89  
ASN   N   H    sing N N 90  
ASN   N   H2   sing N N 91  
ASN   CA  C    sing N N 92  
ASN   CA  CB   sing N N 93  
ASN   CA  HA   sing N N 94  
ASN   C   O    doub N N 95  
ASN   C   OXT  sing N N 96  
ASN   CB  CG   sing N N 97  
ASN   CB  HB2  sing N N 98  
ASN   CB  HB3  sing N N 99  
ASN   CG  OD1  doub N N 100 
ASN   CG  ND2  sing N N 101 
ASN   ND2 HD21 sing N N 102 
ASN   ND2 HD22 sing N N 103 
ASN   OXT HXT  sing N N 104 
ASP   N   CA   sing N N 105 
ASP   N   H    sing N N 106 
ASP   N   H2   sing N N 107 
ASP   CA  C    sing N N 108 
ASP   CA  CB   sing N N 109 
ASP   CA  HA   sing N N 110 
ASP   C   O    doub N N 111 
ASP   C   OXT  sing N N 112 
ASP   CB  CG   sing N N 113 
ASP   CB  HB2  sing N N 114 
ASP   CB  HB3  sing N N 115 
ASP   CG  OD1  doub N N 116 
ASP   CG  OD2  sing N N 117 
ASP   OD2 HD2  sing N N 118 
ASP   OXT HXT  sing N N 119 
CYS   N   CA   sing N N 120 
CYS   N   H    sing N N 121 
CYS   N   H2   sing N N 122 
CYS   CA  C    sing N N 123 
CYS   CA  CB   sing N N 124 
CYS   CA  HA   sing N N 125 
CYS   C   O    doub N N 126 
CYS   C   OXT  sing N N 127 
CYS   CB  SG   sing N N 128 
CYS   CB  HB2  sing N N 129 
CYS   CB  HB3  sing N N 130 
CYS   SG  HG   sing N N 131 
CYS   OXT HXT  sing N N 132 
GLN   N   CA   sing N N 133 
GLN   N   H    sing N N 134 
GLN   N   H2   sing N N 135 
GLN   CA  C    sing N N 136 
GLN   CA  CB   sing N N 137 
GLN   CA  HA   sing N N 138 
GLN   C   O    doub N N 139 
GLN   C   OXT  sing N N 140 
GLN   CB  CG   sing N N 141 
GLN   CB  HB2  sing N N 142 
GLN   CB  HB3  sing N N 143 
GLN   CG  CD   sing N N 144 
GLN   CG  HG2  sing N N 145 
GLN   CG  HG3  sing N N 146 
GLN   CD  OE1  doub N N 147 
GLN   CD  NE2  sing N N 148 
GLN   NE2 HE21 sing N N 149 
GLN   NE2 HE22 sing N N 150 
GLN   OXT HXT  sing N N 151 
GLU   N   CA   sing N N 152 
GLU   N   H    sing N N 153 
GLU   N   H2   sing N N 154 
GLU   CA  C    sing N N 155 
GLU   CA  CB   sing N N 156 
GLU   CA  HA   sing N N 157 
GLU   C   O    doub N N 158 
GLU   C   OXT  sing N N 159 
GLU   CB  CG   sing N N 160 
GLU   CB  HB2  sing N N 161 
GLU   CB  HB3  sing N N 162 
GLU   CG  CD   sing N N 163 
GLU   CG  HG2  sing N N 164 
GLU   CG  HG3  sing N N 165 
GLU   CD  OE1  doub N N 166 
GLU   CD  OE2  sing N N 167 
GLU   OE2 HE2  sing N N 168 
GLU   OXT HXT  sing N N 169 
GLY   N   CA   sing N N 170 
GLY   N   H    sing N N 171 
GLY   N   H2   sing N N 172 
GLY   CA  C    sing N N 173 
GLY   CA  HA2  sing N N 174 
GLY   CA  HA3  sing N N 175 
GLY   C   O    doub N N 176 
GLY   C   OXT  sing N N 177 
GLY   OXT HXT  sing N N 178 
HIS   N   CA   sing N N 179 
HIS   N   H    sing N N 180 
HIS   N   H2   sing N N 181 
HIS   CA  C    sing N N 182 
HIS   CA  CB   sing N N 183 
HIS   CA  HA   sing N N 184 
HIS   C   O    doub N N 185 
HIS   C   OXT  sing N N 186 
HIS   CB  CG   sing N N 187 
HIS   CB  HB2  sing N N 188 
HIS   CB  HB3  sing N N 189 
HIS   CG  ND1  sing Y N 190 
HIS   CG  CD2  doub Y N 191 
HIS   ND1 CE1  doub Y N 192 
HIS   ND1 HD1  sing N N 193 
HIS   CD2 NE2  sing Y N 194 
HIS   CD2 HD2  sing N N 195 
HIS   CE1 NE2  sing Y N 196 
HIS   CE1 HE1  sing N N 197 
HIS   NE2 HE2  sing N N 198 
HIS   OXT HXT  sing N N 199 
HOH   O   H1   sing N N 200 
HOH   O   H2   sing N N 201 
ILE   N   CA   sing N N 202 
ILE   N   H    sing N N 203 
ILE   N   H2   sing N N 204 
ILE   CA  C    sing N N 205 
ILE   CA  CB   sing N N 206 
ILE   CA  HA   sing N N 207 
ILE   C   O    doub N N 208 
ILE   C   OXT  sing N N 209 
ILE   CB  CG1  sing N N 210 
ILE   CB  CG2  sing N N 211 
ILE   CB  HB   sing N N 212 
ILE   CG1 CD1  sing N N 213 
ILE   CG1 HG12 sing N N 214 
ILE   CG1 HG13 sing N N 215 
ILE   CG2 HG21 sing N N 216 
ILE   CG2 HG22 sing N N 217 
ILE   CG2 HG23 sing N N 218 
ILE   CD1 HD11 sing N N 219 
ILE   CD1 HD12 sing N N 220 
ILE   CD1 HD13 sing N N 221 
ILE   OXT HXT  sing N N 222 
LEU   N   CA   sing N N 223 
LEU   N   H    sing N N 224 
LEU   N   H2   sing N N 225 
LEU   CA  C    sing N N 226 
LEU   CA  CB   sing N N 227 
LEU   CA  HA   sing N N 228 
LEU   C   O    doub N N 229 
LEU   C   OXT  sing N N 230 
LEU   CB  CG   sing N N 231 
LEU   CB  HB2  sing N N 232 
LEU   CB  HB3  sing N N 233 
LEU   CG  CD1  sing N N 234 
LEU   CG  CD2  sing N N 235 
LEU   CG  HG   sing N N 236 
LEU   CD1 HD11 sing N N 237 
LEU   CD1 HD12 sing N N 238 
LEU   CD1 HD13 sing N N 239 
LEU   CD2 HD21 sing N N 240 
LEU   CD2 HD22 sing N N 241 
LEU   CD2 HD23 sing N N 242 
LEU   OXT HXT  sing N N 243 
LYS   N   CA   sing N N 244 
LYS   N   H    sing N N 245 
LYS   N   H2   sing N N 246 
LYS   CA  C    sing N N 247 
LYS   CA  CB   sing N N 248 
LYS   CA  HA   sing N N 249 
LYS   C   O    doub N N 250 
LYS   C   OXT  sing N N 251 
LYS   CB  CG   sing N N 252 
LYS   CB  HB2  sing N N 253 
LYS   CB  HB3  sing N N 254 
LYS   CG  CD   sing N N 255 
LYS   CG  HG2  sing N N 256 
LYS   CG  HG3  sing N N 257 
LYS   CD  CE   sing N N 258 
LYS   CD  HD2  sing N N 259 
LYS   CD  HD3  sing N N 260 
LYS   CE  NZ   sing N N 261 
LYS   CE  HE2  sing N N 262 
LYS   CE  HE3  sing N N 263 
LYS   NZ  HZ1  sing N N 264 
LYS   NZ  HZ2  sing N N 265 
LYS   NZ  HZ3  sing N N 266 
LYS   OXT HXT  sing N N 267 
MET   N   CA   sing N N 268 
MET   N   H    sing N N 269 
MET   N   H2   sing N N 270 
MET   CA  C    sing N N 271 
MET   CA  CB   sing N N 272 
MET   CA  HA   sing N N 273 
MET   C   O    doub N N 274 
MET   C   OXT  sing N N 275 
MET   CB  CG   sing N N 276 
MET   CB  HB2  sing N N 277 
MET   CB  HB3  sing N N 278 
MET   CG  SD   sing N N 279 
MET   CG  HG2  sing N N 280 
MET   CG  HG3  sing N N 281 
MET   SD  CE   sing N N 282 
MET   CE  HE1  sing N N 283 
MET   CE  HE2  sing N N 284 
MET   CE  HE3  sing N N 285 
MET   OXT HXT  sing N N 286 
PHE   N   CA   sing N N 287 
PHE   N   H    sing N N 288 
PHE   N   H2   sing N N 289 
PHE   CA  C    sing N N 290 
PHE   CA  CB   sing N N 291 
PHE   CA  HA   sing N N 292 
PHE   C   O    doub N N 293 
PHE   C   OXT  sing N N 294 
PHE   CB  CG   sing N N 295 
PHE   CB  HB2  sing N N 296 
PHE   CB  HB3  sing N N 297 
PHE   CG  CD1  doub Y N 298 
PHE   CG  CD2  sing Y N 299 
PHE   CD1 CE1  sing Y N 300 
PHE   CD1 HD1  sing N N 301 
PHE   CD2 CE2  doub Y N 302 
PHE   CD2 HD2  sing N N 303 
PHE   CE1 CZ   doub Y N 304 
PHE   CE1 HE1  sing N N 305 
PHE   CE2 CZ   sing Y N 306 
PHE   CE2 HE2  sing N N 307 
PHE   CZ  HZ   sing N N 308 
PHE   OXT HXT  sing N N 309 
PRO   N   CA   sing N N 310 
PRO   N   CD   sing N N 311 
PRO   N   H    sing N N 312 
PRO   CA  C    sing N N 313 
PRO   CA  CB   sing N N 314 
PRO   CA  HA   sing N N 315 
PRO   C   O    doub N N 316 
PRO   C   OXT  sing N N 317 
PRO   CB  CG   sing N N 318 
PRO   CB  HB2  sing N N 319 
PRO   CB  HB3  sing N N 320 
PRO   CG  CD   sing N N 321 
PRO   CG  HG2  sing N N 322 
PRO   CG  HG3  sing N N 323 
PRO   CD  HD2  sing N N 324 
PRO   CD  HD3  sing N N 325 
PRO   OXT HXT  sing N N 326 
SER   N   CA   sing N N 327 
SER   N   H    sing N N 328 
SER   N   H2   sing N N 329 
SER   CA  C    sing N N 330 
SER   CA  CB   sing N N 331 
SER   CA  HA   sing N N 332 
SER   C   O    doub N N 333 
SER   C   OXT  sing N N 334 
SER   CB  OG   sing N N 335 
SER   CB  HB2  sing N N 336 
SER   CB  HB3  sing N N 337 
SER   OG  HG   sing N N 338 
SER   OXT HXT  sing N N 339 
THR   N   CA   sing N N 340 
THR   N   H    sing N N 341 
THR   N   H2   sing N N 342 
THR   CA  C    sing N N 343 
THR   CA  CB   sing N N 344 
THR   CA  HA   sing N N 345 
THR   C   O    doub N N 346 
THR   C   OXT  sing N N 347 
THR   CB  OG1  sing N N 348 
THR   CB  CG2  sing N N 349 
THR   CB  HB   sing N N 350 
THR   OG1 HG1  sing N N 351 
THR   CG2 HG21 sing N N 352 
THR   CG2 HG22 sing N N 353 
THR   CG2 HG23 sing N N 354 
THR   OXT HXT  sing N N 355 
TRP   N   CA   sing N N 356 
TRP   N   H    sing N N 357 
TRP   N   H2   sing N N 358 
TRP   CA  C    sing N N 359 
TRP   CA  CB   sing N N 360 
TRP   CA  HA   sing N N 361 
TRP   C   O    doub N N 362 
TRP   C   OXT  sing N N 363 
TRP   CB  CG   sing N N 364 
TRP   CB  HB2  sing N N 365 
TRP   CB  HB3  sing N N 366 
TRP   CG  CD1  doub Y N 367 
TRP   CG  CD2  sing Y N 368 
TRP   CD1 NE1  sing Y N 369 
TRP   CD1 HD1  sing N N 370 
TRP   CD2 CE2  doub Y N 371 
TRP   CD2 CE3  sing Y N 372 
TRP   NE1 CE2  sing Y N 373 
TRP   NE1 HE1  sing N N 374 
TRP   CE2 CZ2  sing Y N 375 
TRP   CE3 CZ3  doub Y N 376 
TRP   CE3 HE3  sing N N 377 
TRP   CZ2 CH2  doub Y N 378 
TRP   CZ2 HZ2  sing N N 379 
TRP   CZ3 CH2  sing Y N 380 
TRP   CZ3 HZ3  sing N N 381 
TRP   CH2 HH2  sing N N 382 
TRP   OXT HXT  sing N N 383 
TYR   N   CA   sing N N 384 
TYR   N   H    sing N N 385 
TYR   N   H2   sing N N 386 
TYR   CA  C    sing N N 387 
TYR   CA  CB   sing N N 388 
TYR   CA  HA   sing N N 389 
TYR   C   O    doub N N 390 
TYR   C   OXT  sing N N 391 
TYR   CB  CG   sing N N 392 
TYR   CB  HB2  sing N N 393 
TYR   CB  HB3  sing N N 394 
TYR   CG  CD1  doub Y N 395 
TYR   CG  CD2  sing Y N 396 
TYR   CD1 CE1  sing Y N 397 
TYR   CD1 HD1  sing N N 398 
TYR   CD2 CE2  doub Y N 399 
TYR   CD2 HD2  sing N N 400 
TYR   CE1 CZ   doub Y N 401 
TYR   CE1 HE1  sing N N 402 
TYR   CE2 CZ   sing Y N 403 
TYR   CE2 HE2  sing N N 404 
TYR   CZ  OH   sing N N 405 
TYR   OH  HH   sing N N 406 
TYR   OXT HXT  sing N N 407 
VAL   N   CA   sing N N 408 
VAL   N   H    sing N N 409 
VAL   N   H2   sing N N 410 
VAL   CA  C    sing N N 411 
VAL   CA  CB   sing N N 412 
VAL   CA  HA   sing N N 413 
VAL   C   O    doub N N 414 
VAL   C   OXT  sing N N 415 
VAL   CB  CG1  sing N N 416 
VAL   CB  CG2  sing N N 417 
VAL   CB  HB   sing N N 418 
VAL   CG1 HG11 sing N N 419 
VAL   CG1 HG12 sing N N 420 
VAL   CG1 HG13 sing N N 421 
VAL   CG2 HG21 sing N N 422 
VAL   CG2 HG22 sing N N 423 
VAL   CG2 HG23 sing N N 424 
VAL   OXT HXT  sing N N 425 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           22277019 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5WQA 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8ZQW 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017311 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012466 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006138 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F  ? ? 4.90428  4.07044 12.99538 1.63651  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
MG ? ? 9.41153  2.53737 2.59044  63.03566 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 2.14387  29.76375 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASP   A 1 90  ? -7.21001  -20.79497 8.29799  1.000 34.32649 ? 90  ASP   A N   1 
ATOM   2    C  CA  . ASP   A 1 90  ? -6.43940  -19.97447 7.36992  1.000 37.47453 ? 90  ASP   A CA  1 
ATOM   3    C  C   . ASP   A 1 90  ? -6.95413  -18.54123 7.33449  1.000 28.32308 ? 90  ASP   A C   1 
ATOM   4    O  O   . ASP   A 1 90  ? -6.22722  -17.60261 7.66040  1.000 27.71171 ? 90  ASP   A O   1 
ATOM   5    C  CB  . ASP   A 1 90  ? -6.47604  -20.57327 5.96318  1.000 42.80532 ? 90  ASP   A CB  1 
ATOM   6    C  CG  . ASP   A 1 90  ? -5.23550  -21.37967 5.64200  1.000 58.02915 ? 90  ASP   A CG  1 
ATOM   7    O  OD1 . ASP   A 1 90  ? -4.32232  -21.43170 6.49285  1.000 60.63534 ? 90  ASP   A OD1 1 
ATOM   8    O  OD2 . ASP   A 1 90  ? -5.16896  -21.95282 4.53444  1.000 62.69868 ? 90  ASP   A OD2 1 
ATOM   9    N  N   . VAL   A 1 91  ? -8.21483  -18.38287 6.92580  1.000 25.57703 ? 91  VAL   A N   1 
ATOM   10   C  CA  . VAL   A 1 91  ? -8.81865  -17.05460 6.86847  1.000 28.47746 ? 91  VAL   A CA  1 
ATOM   11   C  C   . VAL   A 1 91  ? -8.88756  -16.44185 8.26149  1.000 27.87997 ? 91  VAL   A C   1 
ATOM   12   O  O   . VAL   A 1 91  ? -8.65949  -15.23864 8.44043  1.000 27.54186 ? 91  VAL   A O   1 
ATOM   13   C  CB  . VAL   A 1 91  ? -10.20840 -17.13220 6.20916  1.000 23.34977 ? 91  VAL   A CB  1 
ATOM   14   C  CG1 . VAL   A 1 91  ? -10.87675 -15.76821 6.20848  1.000 26.55135 ? 91  VAL   A CG1 1 
ATOM   15   C  CG2 . VAL   A 1 91  ? -10.09195 -17.67608 4.79198  1.000 30.38468 ? 91  VAL   A CG2 1 
ATOM   16   N  N   . LEU   A 1 92  ? -9.19326  -17.26119 9.27034  1.000 24.71172 ? 92  LEU   A N   1 
ATOM   17   C  CA  . LEU   A 1 92  ? -9.23600  -16.77066 10.64442 1.000 23.67341 ? 92  LEU   A CA  1 
ATOM   18   C  C   . LEU   A 1 92  ? -7.85672  -16.31831 11.10873 1.000 28.35813 ? 92  LEU   A C   1 
ATOM   19   O  O   . LEU   A 1 92  ? -7.71124  -15.24577 11.70770 1.000 24.21112 ? 92  LEU   A O   1 
ATOM   20   C  CB  . LEU   A 1 92  ? -9.79037  -17.85582 11.56782 1.000 23.61066 ? 92  LEU   A CB  1 
ATOM   21   C  CG  . LEU   A 1 92  ? -9.75475  -17.57747 13.07155 1.000 22.02676 ? 92  LEU   A CG  1 
ATOM   22   C  CD1 . LEU   A 1 92  ? -10.48790 -16.28706 13.40417 1.000 19.05531 ? 92  LEU   A CD1 1 
ATOM   23   C  CD2 . LEU   A 1 92  ? -10.34682 -18.74876 13.83996 1.000 23.75532 ? 92  LEU   A CD2 1 
ATOM   24   N  N   . ALA   A 1 93  ? -6.82842  -17.12979 10.84293 1.000 26.96811 ? 93  ALA   A N   1 
ATOM   25   C  CA  . ALA   A 1 93  ? -5.46659  -16.73441 11.18752 1.000 27.15917 ? 93  ALA   A CA  1 
ATOM   26   C  C   . ALA   A 1 93  ? -5.06303  -15.44983 10.47722 1.000 25.81086 ? 93  ALA   A C   1 
ATOM   27   O  O   . ALA   A 1 93  ? -4.31661  -14.63762 11.03664 1.000 25.06760 ? 93  ALA   A O   1 
ATOM   28   C  CB  . ALA   A 1 93  ? -4.49116  -17.86140 10.84608 1.000 24.33127 ? 93  ALA   A CB  1 
ATOM   29   N  N   . LYS   A 1 94  ? -5.55461  -15.24628 9.25309  1.000 22.76827 ? 94  LYS   A N   1 
ATOM   30   C  CA  . LYS   A 1 94  ? -5.26087  -14.01891 8.52115  1.000 29.22143 ? 94  LYS   A CA  1 
ATOM   31   C  C   . LYS   A 1 94  ? -5.87968  -12.80503 9.20455  1.000 26.40891 ? 94  LYS   A C   1 
ATOM   32   O  O   . LYS   A 1 94  ? -5.22911  -11.76166 9.33442  1.000 26.80781 ? 94  LYS   A O   1 
ATOM   33   C  CB  . LYS   A 1 94  ? -5.76089  -14.14499 7.08192  1.000 27.41663 ? 94  LYS   A CB  1 
ATOM   34   C  CG  . LYS   A 1 94  ? -5.41439  -12.97463 6.17839  1.000 31.94133 ? 94  LYS   A CG  1 
ATOM   35   C  CD  . LYS   A 1 94  ? -5.86902  -13.25235 4.75712  1.000 41.17196 ? 94  LYS   A CD  1 
ATOM   36   C  CE  . LYS   A 1 94  ? -7.37524  -13.10262 4.63863  1.000 48.56437 ? 94  LYS   A CE  1 
ATOM   37   N  NZ  . LYS   A 1 94  ? -7.92841  -13.88036 3.49628  1.000 54.14457 ? 94  LYS   A NZ  1 
ATOM   38   N  N   . GLU   A 1 95  ? -7.13422  -12.92248 9.64981  1.000 24.79201 ? 95  GLU   A N   1 
ATOM   39   C  CA  . GLU   A 1 95  ? -7.78525  -11.81117 10.33792 1.000 23.69223 ? 95  GLU   A CA  1 
ATOM   40   C  C   . GLU   A 1 95  ? -7.14712  -11.54960 11.69682 1.000 22.25914 ? 95  GLU   A C   1 
ATOM   41   O  O   . GLU   A 1 95  ? -7.02556  -10.39369 12.11979 1.000 24.67960 ? 95  GLU   A O   1 
ATOM   42   C  CB  . GLU   A 1 95  ? -9.27969  -12.09366 10.49453 1.000 21.36623 ? 95  GLU   A CB  1 
ATOM   43   C  CG  . GLU   A 1 95  ? -10.04555 -12.15044 9.18357  1.000 30.09881 ? 95  GLU   A CG  1 
ATOM   44   C  CD  . GLU   A 1 95  ? -10.29048 -10.77773 8.58796  1.000 24.14983 ? 95  GLU   A CD  1 
ATOM   45   O  OE1 . GLU   A 1 95  ? -10.20515 -9.77925  9.33275  1.000 23.27038 ? 95  GLU   A OE1 1 
ATOM   46   O  OE2 . GLU   A 1 95  ? -10.57018 -10.69800 7.37401  1.000 33.60435 ? 95  GLU   A OE2 1 
ATOM   47   N  N   . LEU   A 1 96  ? -6.72925  -12.60835 12.39377 1.000 22.89279 ? 96  LEU   A N   1 
ATOM   48   C  CA  . LEU   A 1 96  ? -6.10628  -12.45166 13.70252 1.000 24.78293 ? 96  LEU   A CA  1 
ATOM   49   C  C   . LEU   A 1 96  ? -4.73636  -11.79017 13.63154 1.000 30.56779 ? 96  LEU   A C   1 
ATOM   50   O  O   . LEU   A 1 96  ? -4.20227  -11.40285 14.67626 1.000 28.60742 ? 96  LEU   A O   1 
ATOM   51   C  CB  . LEU   A 1 96  ? -6.00315  -13.81156 14.39518 1.000 22.94177 ? 96  LEU   A CB  1 
ATOM   52   C  CG  . LEU   A 1 96  ? -7.33558  -14.32096 14.94968 1.000 19.62332 ? 96  LEU   A CG  1 
ATOM   53   C  CD1 . LEU   A 1 96  ? -7.24518  -15.78280 15.34941 1.000 21.14672 ? 96  LEU   A CD1 1 
ATOM   54   C  CD2 . LEU   A 1 96  ? -7.77179  -13.46837 16.13294 1.000 22.27094 ? 96  LEU   A CD2 1 
ATOM   55   N  N   . GLU   A 1 97  ? -4.15849  -11.64845 12.43663 1.000 27.37365 ? 97  GLU   A N   1 
ATOM   56   C  CA  . GLU   A 1 97  ? -2.95246  -10.84601 12.27868 1.000 32.56364 ? 97  GLU   A CA  1 
ATOM   57   C  C   . GLU   A 1 97  ? -3.20538  -9.36330  12.52015 1.000 29.30316 ? 97  GLU   A C   1 
ATOM   58   O  O   . GLU   A 1 97  ? -2.24155  -8.60620  12.67630 1.000 24.94852 ? 97  GLU   A O   1 
ATOM   59   C  CB  . GLU   A 1 97  ? -2.36051  -11.05016 10.88160 1.000 33.47270 ? 97  GLU   A CB  1 
ATOM   60   C  CG  . GLU   A 1 97  ? -1.70260  -12.40683 10.67428 1.000 30.56580 ? 97  GLU   A CG  1 
ATOM   61   C  CD  . GLU   A 1 97  ? -1.36272  -12.68022 9.22011  1.000 38.82549 ? 97  GLU   A CD  1 
ATOM   62   O  OE1 . GLU   A 1 97  ? -1.01933  -11.72219 8.49558  1.000 37.64957 ? 97  GLU   A OE1 1 
ATOM   63   O  OE2 . GLU   A 1 97  ? -1.43774  -13.85537 8.80211  1.000 43.12016 ? 97  GLU   A OE2 1 
ATOM   64   N  N   . ASP   A 1 98  ? -4.46748  -8.93600  12.55406 1.000 27.20161 ? 98  ASP   A N   1 
ATOM   65   C  CA  . ASP   A 1 98  ? -4.83688  -7.55369  12.82818 1.000 28.24864 ? 98  ASP   A CA  1 
ATOM   66   C  C   . ASP   A 1 98  ? -5.05351  -7.27958  14.31229 1.000 26.55594 ? 98  ASP   A C   1 
ATOM   67   O  O   . ASP   A 1 98  ? -5.53096  -6.19611  14.66313 1.000 22.47020 ? 98  ASP   A O   1 
ATOM   68   C  CB  . ASP   A 1 98  ? -6.10890  -7.18242  12.06002 1.000 29.00335 ? 98  ASP   A CB  1 
ATOM   69   C  CG  . ASP   A 1 98  ? -5.87336  -7.03188  10.57253 1.000 35.73773 ? 98  ASP   A CG  1 
ATOM   70   O  OD1 . ASP   A 1 98  ? -4.70425  -6.86736  10.16601 1.000 35.20225 ? 98  ASP   A OD1 1 
ATOM   71   O  OD2 . ASP   A 1 98  ? -6.86291  -7.07245  9.81060  1.000 31.31702 ? 98  ASP   A OD2 1 
ATOM   72   N  N   . VAL   A 1 99  ? -4.70468  -8.22638  15.18817 1.000 23.58533 ? 99  VAL   A N   1 
ATOM   73   C  CA  . VAL   A 1 99  ? -5.07136  -8.12510  16.59784 1.000 20.87790 ? 99  VAL   A CA  1 
ATOM   74   C  C   . VAL   A 1 99  ? -4.41294  -6.93452  17.29120 1.000 21.50789 ? 99  VAL   A C   1 
ATOM   75   O  O   . VAL   A 1 99  ? -4.88445  -6.50305  18.35054 1.000 22.98889 ? 99  VAL   A O   1 
ATOM   76   C  CB  . VAL   A 1 99  ? -4.73469  -9.44682  17.31702 1.000 23.70814 ? 99  VAL   A CB  1 
ATOM   77   C  CG1 . VAL   A 1 99  ? -3.22812  -9.62190  17.44614 1.000 23.07881 ? 99  VAL   A CG1 1 
ATOM   78   C  CG2 . VAL   A 1 99  ? -5.42498  -9.52262  18.67556 1.000 23.07354 ? 99  VAL   A CG2 1 
ATOM   79   N  N   . ASN   A 1 100 ? -3.34351  -6.37958  16.72557 1.000 19.94911 ? 100 ASN   A N   1 
ATOM   80   C  CA  . ASN   A 1 100 ? -2.71520  -5.18843  17.28287 1.000 22.43192 ? 100 ASN   A CA  1 
ATOM   81   C  C   . ASN   A 1 100 ? -3.27569  -3.89790  16.70206 1.000 17.66902 ? 100 ASN   A C   1 
ATOM   82   O  O   . ASN   A 1 100 ? -2.78656  -2.81719  17.04612 1.000 18.77005 ? 100 ASN   A O   1 
ATOM   83   C  CB  . ASN   A 1 100 ? -1.19912  -5.22901  17.05884 1.000 21.65485 ? 100 ASN   A CB  1 
ATOM   84   C  CG  . ASN   A 1 100 ? -0.52079  -6.31906  17.86085 1.000 24.94912 ? 100 ASN   A CG  1 
ATOM   85   O  OD1 . ASN   A 1 100 ? -1.08779  -6.84201  18.81938 1.000 28.05733 ? 100 ASN   A OD1 1 
ATOM   86   N  ND2 . ASN   A 1 100 ? 0.70245   -6.66510  17.47606 1.000 29.61865 ? 100 ASN   A ND2 1 
ATOM   87   N  N   . LYS   A 1 101 ? -4.28891  -3.97980  15.84557 1.000 21.26691 ? 101 LYS   A N   1 
ATOM   88   C  CA  . LYS   A 1 101 ? -4.79473  -2.82899  15.11116 1.000 19.22771 ? 101 LYS   A CA  1 
ATOM   89   C  C   . LYS   A 1 101 ? -6.16299  -2.41669  15.63344 1.000 21.78061 ? 101 LYS   A C   1 
ATOM   90   O  O   . LYS   A 1 101 ? -7.04996  -3.25989  15.80835 1.000 17.53915 ? 101 LYS   A O   1 
ATOM   91   C  CB  . LYS   A 1 101 ? -4.88314  -3.13380  13.61441 1.000 20.32750 ? 101 LYS   A CB  1 
ATOM   92   C  CG  . LYS   A 1 101 ? -3.53930  -3.28489  12.92758 1.000 26.70314 ? 101 LYS   A CG  1 
ATOM   93   C  CD  . LYS   A 1 101 ? -3.67569  -4.09800  11.65263 1.000 33.66766 ? 101 LYS   A CD  1 
ATOM   94   C  CE  . LYS   A 1 101 ? -2.40130  -4.06305  10.82733 1.000 36.86507 ? 101 LYS   A CE  1 
ATOM   95   N  NZ  . LYS   A 1 101 ? -2.61742  -3.37757  9.52286  1.000 38.80488 ? 101 LYS   A NZ  1 
ATOM   96   N  N   . TRP   A 1 102 ? -6.31900  -1.11961  15.88541 1.000 19.12338 ? 102 TRP   A N   1 
ATOM   97   C  CA  . TRP   A 1 102 ? -7.63544  -0.53846  16.10015 1.000 15.47757 ? 102 TRP   A CA  1 
ATOM   98   C  C   . TRP   A 1 102 ? -8.51312  -0.81065  14.88512 1.000 21.57750 ? 102 TRP   A C   1 
ATOM   99   O  O   . TRP   A 1 102 ? -8.08041  -0.65450  13.74013 1.000 23.56130 ? 102 TRP   A O   1 
ATOM   100  C  CB  . TRP   A 1 102 ? -7.49799  0.96828   16.33028 1.000 18.08143 ? 102 TRP   A CB  1 
ATOM   101  C  CG  . TRP   A 1 102 ? -8.56016  1.60219   17.18063 1.000 15.71936 ? 102 TRP   A CG  1 
ATOM   102  C  CD1 . TRP   A 1 102 ? -9.54671  2.44999   16.76528 1.000 13.38768 ? 102 TRP   A CD1 1 
ATOM   103  C  CD2 . TRP   A 1 102 ? -8.71927  1.46686   18.59814 1.000 13.04132 ? 102 TRP   A CD2 1 
ATOM   104  N  NE1 . TRP   A 1 102 ? -10.31678 2.84056   17.83438 1.000 14.63935 ? 102 TRP   A NE1 1 
ATOM   105  C  CE2 . TRP   A 1 102 ? -9.82852  2.25224   18.97130 1.000 13.40321 ? 102 TRP   A CE2 1 
ATOM   106  C  CE3 . TRP   A 1 102 ? -8.03576  0.75240   19.58691 1.000 14.77574 ? 102 TRP   A CE3 1 
ATOM   107  C  CZ2 . TRP   A 1 102 ? -10.27198 2.33980   20.29011 1.000 14.19072 ? 102 TRP   A CZ2 1 
ATOM   108  C  CZ3 . TRP   A 1 102 ? -8.47618  0.84261   20.89570 1.000 15.05068 ? 102 TRP   A CZ3 1 
ATOM   109  C  CH2 . TRP   A 1 102 ? -9.58319  1.63066   21.23505 1.000 13.24107 ? 102 TRP   A CH2 1 
ATOM   110  N  N   . GLY   A 1 103 ? -9.74933  -1.23009  15.13195 1.000 19.58593 ? 103 GLY   A N   1 
ATOM   111  C  CA  . GLY   A 1 103 ? -10.63349 -1.54811  14.03308 1.000 20.61827 ? 103 GLY   A CA  1 
ATOM   112  C  C   . GLY   A 1 103 ? -10.46906 -2.93507  13.46052 1.000 24.30227 ? 103 GLY   A C   1 
ATOM   113  O  O   . GLY   A 1 103 ? -10.91394 -3.17455  12.33015 1.000 26.91296 ? 103 GLY   A O   1 
ATOM   114  N  N   . LEU   A 1 104 ? -9.80036  -3.83760  14.18232 1.000 20.15545 ? 104 LEU   A N   1 
ATOM   115  C  CA  . LEU   A 1 104 ? -9.92138  -5.26776  13.93164 1.000 20.32519 ? 104 LEU   A CA  1 
ATOM   116  C  C   . LEU   A 1 104 ? -11.37068 -5.60941  13.63470 1.000 22.92834 ? 104 LEU   A C   1 
ATOM   117  O  O   . LEU   A 1 104 ? -12.27890 -5.10070  14.29132 1.000 23.41559 ? 104 LEU   A O   1 
ATOM   118  C  CB  . LEU   A 1 104 ? -9.45965  -6.04524  15.17013 1.000 18.33557 ? 104 LEU   A CB  1 
ATOM   119  C  CG  . LEU   A 1 104 ? -9.76406  -7.54057  15.19754 1.000 18.49393 ? 104 LEU   A CG  1 
ATOM   120  C  CD1 . LEU   A 1 104 ? -8.66247  -8.28716  14.47509 1.000 24.29696 ? 104 LEU   A CD1 1 
ATOM   121  C  CD2 . LEU   A 1 104 ? -9.94158  -8.04778  16.62212 1.000 19.06512 ? 104 LEU   A CD2 1 
ATOM   122  N  N   . HIS   A 1 105 ? -11.60404 -6.45787  12.63799 1.000 22.99440 ? 105 HIS   A N   1 
ATOM   123  C  CA  . HIS   A 1 105 ? -12.99263 -6.80423  12.35181 1.000 26.54935 ? 105 HIS   A CA  1 
ATOM   124  C  C   . HIS   A 1 105 ? -13.39697 -7.94580  13.27134 1.000 22.54771 ? 105 HIS   A C   1 
ATOM   125  O  O   . HIS   A 1 105 ? -13.25556 -9.12695  12.94878 1.000 21.76226 ? 105 HIS   A O   1 
ATOM   126  C  CB  . HIS   A 1 105 ? -13.22572 -7.14503  10.89043 1.000 25.90181 ? 105 HIS   A CB  1 
ATOM   127  C  CG  . HIS   A 1 105 ? -14.65885 -6.99340  10.49844 1.000 36.79358 ? 105 HIS   A CG  1 
ATOM   128  N  ND1 . HIS   A 1 105 ? -15.68468 -7.51948  11.25232 1.000 27.37822 ? 105 HIS   A ND1 1 
ATOM   129  C  CD2 . HIS   A 1 105 ? -15.24563 -6.32530  9.47933  1.000 40.78032 ? 105 HIS   A CD2 1 
ATOM   130  C  CE1 . HIS   A 1 105 ? -16.84112 -7.21164  10.69571 1.000 29.09223 ? 105 HIS   A CE1 1 
ATOM   131  N  NE2 . HIS   A 1 105 ? -16.60299 -6.48745  9.61777  1.000 44.02278 ? 105 HIS   A NE2 1 
ATOM   132  N  N   . VAL   A 1 106 ? -13.92578 -7.56748  14.43437 1.000 20.78553 ? 106 VAL   A N   1 
ATOM   133  C  CA  . VAL   A 1 106 ? -14.28025 -8.53337  15.46367 1.000 19.12592 ? 106 VAL   A CA  1 
ATOM   134  C  C   . VAL   A 1 106 ? -15.52092 -9.32903  15.06969 1.000 17.80189 ? 106 VAL   A C   1 
ATOM   135  O  O   . VAL   A 1 106 ? -15.68807 -10.47747 15.49721 1.000 16.23504 ? 106 VAL   A O   1 
ATOM   136  C  CB  . VAL   A 1 106 ? -14.45942 -7.79607  16.80474 1.000 15.15524 ? 106 VAL   A CB  1 
ATOM   137  C  CG1 . VAL   A 1 106 ? -15.64836 -6.83831  16.74240 1.000 11.81135 ? 106 VAL   A CG1 1 
ATOM   138  C  CG2 . VAL   A 1 106 ? -14.59907 -8.78022  17.94998 1.000 15.24222 ? 106 VAL   A CG2 1 
ATOM   139  N  N   . PHE   A 1 107 ? -16.40401 -8.75296  14.24759 1.000 18.30665 ? 107 PHE   A N   1 
ATOM   140  C  CA  . PHE   A 1 107 ? -17.59358 -9.48946  13.82692 1.000 18.17844 ? 107 PHE   A CA  1 
ATOM   141  C  C   . PHE   A 1 107 ? -17.24038 -10.57548 12.81941 1.000 16.92817 ? 107 PHE   A C   1 
ATOM   142  O  O   . PHE   A 1 107 ? -17.81254 -11.67124 12.85440 1.000 15.02311 ? 107 PHE   A O   1 
ATOM   143  C  CB  . PHE   A 1 107 ? -18.63689 -8.53189  13.25197 1.000 18.49493 ? 107 PHE   A CB  1 
ATOM   144  C  CG  . PHE   A 1 107 ? -19.19689 -7.57889  14.26371 1.000 17.88407 ? 107 PHE   A CG  1 
ATOM   145  C  CD1 . PHE   A 1 107 ? -20.17008 -7.99371  15.15752 1.000 14.02061 ? 107 PHE   A CD1 1 
ATOM   146  C  CD2 . PHE   A 1 107 ? -18.74471 -6.27203  14.32978 1.000 19.12738 ? 107 PHE   A CD2 1 
ATOM   147  C  CE1 . PHE   A 1 107 ? -20.68493 -7.12222  16.09760 1.000 21.03059 ? 107 PHE   A CE1 1 
ATOM   148  C  CE2 . PHE   A 1 107 ? -19.25636 -5.39366  15.26689 1.000 19.76155 ? 107 PHE   A CE2 1 
ATOM   149  C  CZ  . PHE   A 1 107 ? -20.22477 -5.82152  16.15543 1.000 17.62687 ? 107 PHE   A CZ  1 
ATOM   150  N  N   . ARG   A 1 108 ? -16.30523 -10.28765 11.91139 1.000 20.61945 ? 108 ARG   A N   1 
ATOM   151  C  CA  . ARG   A 1 108 ? -15.76899 -11.32766 11.03949 1.000 24.25333 ? 108 ARG   A CA  1 
ATOM   152  C  C   . ARG   A 1 108 ? -15.15369 -12.45290 11.85482 1.000 23.10055 ? 108 ARG   A C   1 
ATOM   153  O  O   . ARG   A 1 108 ? -15.43505 -13.63462 11.62335 1.000 24.31146 ? 108 ARG   A O   1 
ATOM   154  C  CB  . ARG   A 1 108 ? -14.72300 -10.73777 10.09648 1.000 29.39834 ? 108 ARG   A CB  1 
ATOM   155  C  CG  . ARG   A 1 108 ? -15.19217 -10.57562 8.67613  1.000 39.76942 ? 108 ARG   A CG  1 
ATOM   156  C  CD  . ARG   A 1 108 ? -14.01814 -10.43821 7.72972  1.000 33.66020 ? 108 ARG   A CD  1 
ATOM   157  N  NE  . ARG   A 1 108 ? -14.22201 -9.32004  6.82087  1.000 45.05408 ? 108 ARG   A NE  1 
ATOM   158  C  CZ  . ARG   A 1 108 ? -13.45256 -8.23998  6.78347  1.000 40.23451 ? 108 ARG   A CZ  1 
ATOM   159  N  NH1 . ARG   A 1 108 ? -12.40473 -8.13351  7.59049  1.000 36.73205 ? 108 ARG   A NH1 1 
ATOM   160  N  NH2 . ARG   A 1 108 ? -13.73066 -7.27066  5.93017  1.000 41.40335 ? 108 ARG   A NH2 1 
ATOM   161  N  N   . ILE   A 1 109 ? -14.30103 -12.09586 12.81644 1.000 17.58456 ? 109 ILE   A N   1 
ATOM   162  C  CA  . ILE   A 1 109 ? -13.62178 -13.09230 13.63475 1.000 19.96151 ? 109 ILE   A CA  1 
ATOM   163  C  C   . ILE   A 1 109 ? -14.62460 -13.92354 14.42072 1.000 20.39883 ? 109 ILE   A C   1 
ATOM   164  O  O   . ILE   A 1 109 ? -14.41541 -15.12388 14.63217 1.000 17.32485 ? 109 ILE   A O   1 
ATOM   165  C  CB  . ILE   A 1 109 ? -12.59382 -12.39241 14.54529 1.000 17.84550 ? 109 ILE   A CB  1 
ATOM   166  C  CG1 . ILE   A 1 109 ? -11.36395 -12.00280 13.72301 1.000 20.66019 ? 109 ILE   A CG1 1 
ATOM   167  C  CG2 . ILE   A 1 109 ? -12.21315 -13.26595 15.73212 1.000 16.12964 ? 109 ILE   A CG2 1 
ATOM   168  C  CD1 . ILE   A 1 109 ? -10.25912 -11.39913 14.53388 1.000 22.06152 ? 109 ILE   A CD1 1 
ATOM   169  N  N   . ALA   A 1 110 ? -15.73642 -13.31694 14.84248 1.000 18.23035 ? 110 ALA   A N   1 
ATOM   170  C  CA  . ALA   A 1 110 ? -16.79782 -14.08715 15.48322 1.000 19.37605 ? 110 ALA   A CA  1 
ATOM   171  C  C   . ALA   A 1 110 ? -17.33431 -15.16104 14.54338 1.000 19.44442 ? 110 ALA   A C   1 
ATOM   172  O  O   . ALA   A 1 110 ? -17.48099 -16.32602 14.93037 1.000 20.59644 ? 110 ALA   A O   1 
ATOM   173  C  CB  . ALA   A 1 110 ? -17.92071 -13.15540 15.94000 1.000 19.34103 ? 110 ALA   A CB  1 
ATOM   174  N  N   . GLU   A 1 111 ? -17.62133 -14.78603 13.29474 1.000 21.12168 ? 111 GLU   A N   1 
ATOM   175  C  CA  . GLU   A 1 111 ? -18.10288 -15.75635 12.31577 1.000 23.90751 ? 111 GLU   A CA  1 
ATOM   176  C  C   . GLU   A 1 111 ? -17.04184 -16.80734 12.01270 1.000 22.71372 ? 111 GLU   A C   1 
ATOM   177  O  O   . GLU   A 1 111 ? -17.31055 -18.01330 12.06519 1.000 25.20381 ? 111 GLU   A O   1 
ATOM   178  C  CB  . GLU   A 1 111 ? -18.52186 -15.03929 11.03207 1.000 26.81412 ? 111 GLU   A CB  1 
ATOM   179  C  CG  . GLU   A 1 111 ? -19.90651 -14.42226 11.07161 1.000 35.96894 ? 111 GLU   A CG  1 
ATOM   180  C  CD  . GLU   A 1 111 ? -20.15553 -13.49244 9.90006  1.000 46.13401 ? 111 GLU   A CD  1 
ATOM   181  O  OE1 . GLU   A 1 111 ? -21.27893 -12.95755 9.79172  1.000 50.86290 ? 111 GLU   A OE1 1 
ATOM   182  O  OE2 . GLU   A 1 111 ? -19.22419 -13.29078 9.09133  1.000 46.35735 ? 111 GLU   A OE2 1 
ATOM   183  N  N   . LEU   A 1 112 ? -15.82347 -16.36348 11.69469 1.000 21.39834 ? 112 LEU   A N   1 
ATOM   184  C  CA  . LEU   A 1 112 ? -14.76831 -17.28161 11.28110 1.000 23.39700 ? 112 LEU   A CA  1 
ATOM   185  C  C   . LEU   A 1 112 ? -14.34437 -18.23376 12.39211 1.000 24.20783 ? 112 LEU   A C   1 
ATOM   186  O  O   . LEU   A 1 112 ? -13.79048 -19.29849 12.09859 1.000 26.78535 ? 112 LEU   A O   1 
ATOM   187  C  CB  . LEU   A 1 112 ? -13.55719 -16.48978 10.78522 1.000 22.44922 ? 112 LEU   A CB  1 
ATOM   188  C  CG  . LEU   A 1 112 ? -13.74866 -15.73628 9.46918  1.000 22.85954 ? 112 LEU   A CG  1 
ATOM   189  C  CD1 . LEU   A 1 112 ? -12.64798 -14.70922 9.27633  1.000 20.86195 ? 112 LEU   A CD1 1 
ATOM   190  C  CD2 . LEU   A 1 112 ? -13.77945 -16.71469 8.30612  1.000 21.16893 ? 112 LEU   A CD2 1 
ATOM   191  N  N   . SER   A 1 113 ? -14.59060 -17.88503 13.65348 1.000 21.70860 ? 113 SER   A N   1 
ATOM   192  C  CA  . SER   A 1 113 ? -14.17311 -18.70325 14.78406 1.000 23.44613 ? 113 SER   A CA  1 
ATOM   193  C  C   . SER   A 1 113 ? -15.28340 -19.60195 15.31192 1.000 22.74567 ? 113 SER   A C   1 
ATOM   194  O  O   . SER   A 1 113 ? -15.10232 -20.24314 16.35155 1.000 24.92545 ? 113 SER   A O   1 
ATOM   195  C  CB  . SER   A 1 113 ? -13.65261 -17.81496 15.91494 1.000 22.57790 ? 113 SER   A CB  1 
ATOM   196  O  OG  . SER   A 1 113 ? -14.70193 -17.03854 16.46702 1.000 21.46247 ? 113 SER   A OG  1 
ATOM   197  N  N   . GLY   A 1 114 ? -16.42137 -19.66782 14.62768 1.000 23.64900 ? 114 GLY   A N   1 
ATOM   198  C  CA  . GLY   A 1 114 ? -17.53599 -20.44645 15.12857 1.000 25.55438 ? 114 GLY   A CA  1 
ATOM   199  C  C   . GLY   A 1 114 ? -18.12251 -19.84366 16.38784 1.000 26.86962 ? 114 GLY   A C   1 
ATOM   200  O  O   . GLY   A 1 114 ? -18.34554 -20.54471 17.38039 1.000 29.81417 ? 114 GLY   A O   1 
ATOM   201  N  N   . ASN   A 1 115 ? -18.38944 -18.53934 16.33965 1.000 24.71947 ? 115 ASN   A N   1 
ATOM   202  C  CA  . ASN   A 1 115 ? -18.87237 -17.76942 17.48552 1.000 25.70439 ? 115 ASN   A CA  1 
ATOM   203  C  C   . ASN   A 1 115 ? -17.99724 -18.00086 18.71463 1.000 21.62107 ? 115 ASN   A C   1 
ATOM   204  O  O   . ASN   A 1 115 ? -18.48067 -18.22801 19.82587 1.000 22.73803 ? 115 ASN   A O   1 
ATOM   205  C  CB  . ASN   A 1 115 ? -20.33777 -18.07753 17.79259 1.000 21.73461 ? 115 ASN   A CB  1 
ATOM   206  C  CG  . ASN   A 1 115 ? -20.97996 -17.01147 18.66163 1.000 28.15209 ? 115 ASN   A CG  1 
ATOM   207  O  OD1 . ASN   A 1 115 ? -20.53561 -15.86267 18.68016 1.000 27.68274 ? 115 ASN   A OD1 1 
ATOM   208  N  ND2 . ASN   A 1 115 ? -22.02191 -17.38753 19.39272 1.000 22.07143 ? 115 ASN   A ND2 1 
ATOM   209  N  N   . ARG   A 1 116 ? -16.68127 -17.94039 18.50404 1.000 21.63236 ? 116 ARG   A N   1 
ATOM   210  C  CA  . ARG   A 1 116 ? -15.71848 -17.93588 19.60729 1.000 21.11766 ? 116 ARG   A CA  1 
ATOM   211  C  C   . ARG   A 1 116 ? -14.73952 -16.76760 19.48382 1.000 17.81526 ? 116 ARG   A C   1 
ATOM   212  O  O   . ARG   A 1 116 ? -13.52447 -16.95850 19.53023 1.000 15.93209 ? 116 ARG   A O   1 
ATOM   213  C  CB  . ARG   A 1 116 ? -14.96792 -19.26308 19.66007 1.000 21.59784 ? 116 ARG   A CB  1 
ATOM   214  C  CG  . ARG   A 1 116 ? -15.84242 -20.47029 19.95601 1.000 26.39191 ? 116 ARG   A CG  1 
ATOM   215  C  CD  . ARG   A 1 116 ? -16.41755 -20.40230 21.36092 1.000 27.45550 ? 116 ARG   A CD  1 
ATOM   216  N  NE  . ARG   A 1 116 ? -16.97413 -21.68352 21.78643 1.000 36.54879 ? 116 ARG   A NE  1 
ATOM   217  C  CZ  . ARG   A 1 116 ? -17.39059 -21.94319 23.02165 1.000 35.48642 ? 116 ARG   A CZ  1 
ATOM   218  N  NH1 . ARG   A 1 116 ? -17.31301 -21.00829 23.95886 1.000 23.92457 ? 116 ARG   A NH1 1 
ATOM   219  N  NH2 . ARG   A 1 116 ? -17.88228 -23.13828 23.32152 1.000 31.48541 ? 116 ARG   A NH2 1 
ATOM   220  N  N   . PRO   A 1 117 ? -15.23618 -15.53005 19.33209 1.000 16.34206 ? 117 PRO   A N   1 
ATOM   221  C  CA  . PRO   A 1 117 ? -14.29401 -14.40334 19.24026 1.000 15.80369 ? 117 PRO   A CA  1 
ATOM   222  C  C   . PRO   A 1 117 ? -13.51060 -14.18572 20.51960 1.000 14.30186 ? 117 PRO   A C   1 
ATOM   223  O  O   . PRO   A 1 117 ? -12.31807 -13.86634 20.46242 1.000 18.04772 ? 117 PRO   A O   1 
ATOM   224  C  CB  . PRO   A 1 117 ? -15.20574 -13.21195 18.91655 1.000 15.56094 ? 117 PRO   A CB  1 
ATOM   225  C  CG  . PRO   A 1 117 ? -16.50981 -13.57904 19.50996 1.000 14.47330 ? 117 PRO   A CG  1 
ATOM   226  C  CD  . PRO   A 1 117 ? -16.63437 -15.05862 19.29462 1.000 16.80460 ? 117 PRO   A CD  1 
ATOM   227  N  N   . LEU   A 1 118 ? -14.14676 -14.36641 21.67891 1.000 12.13285 ? 118 LEU   A N   1 
ATOM   228  C  CA  . LEU   A 1 118 ? -13.45584 -14.13631 22.94289 1.000 13.38298 ? 118 LEU   A CA  1 
ATOM   229  C  C   . LEU   A 1 118 ? -12.33930 -15.14988 23.15823 1.000 14.72421 ? 118 LEU   A C   1 
ATOM   230  O  O   . LEU   A 1 118 ? -11.23927 -14.78465 23.58728 1.000 13.76737 ? 118 LEU   A O   1 
ATOM   231  C  CB  . LEU   A 1 118 ? -14.45230 -14.17825 24.10106 1.000 11.23088 ? 118 LEU   A CB  1 
ATOM   232  C  CG  . LEU   A 1 118 ? -13.87172 -13.91990 25.49300 1.000 14.07914 ? 118 LEU   A CG  1 
ATOM   233  C  CD1 . LEU   A 1 118 ? -13.16060 -12.57443 25.53269 1.000 11.26303 ? 118 LEU   A CD1 1 
ATOM   234  C  CD2 . LEU   A 1 118 ? -14.96015 -13.99035 26.55400 1.000 13.69303 ? 118 LEU   A CD2 1 
ATOM   235  N  N   . THR   A 1 119 ? -12.59645 -16.42404 22.85586 1.000 14.34637 ? 119 THR   A N   1 
ATOM   236  C  CA  . THR   A 1 119 ? -11.58635 -17.45405 23.07909 1.000 15.74892 ? 119 THR   A CA  1 
ATOM   237  C  C   . THR   A 1 119 ? -10.38153 -17.25855 22.16448 1.000 17.22808 ? 119 THR   A C   1 
ATOM   238  O  O   . THR   A 1 119 ? -9.23339  -17.29436 22.62149 1.000 17.26770 ? 119 THR   A O   1 
ATOM   239  C  CB  . THR   A 1 119 ? -12.19443 -18.84383 22.88026 1.000 15.68887 ? 119 THR   A CB  1 
ATOM   240  O  OG1 . THR   A 1 119 ? -13.19362 -19.07824 23.88048 1.000 14.64203 ? 119 THR   A OG1 1 
ATOM   241  C  CG2 . THR   A 1 119 ? -11.11811 -19.91627 22.98811 1.000 16.08138 ? 119 THR   A CG2 1 
ATOM   242  N  N   . VAL   A 1 120 ? -10.61960 -17.03929 20.87002 1.000 16.89908 ? 120 VAL   A N   1 
ATOM   243  C  CA  . VAL   A 1 120 ? -9.50056  -16.95372 19.93620 1.000 16.67553 ? 120 VAL   A CA  1 
ATOM   244  C  C   . VAL   A 1 120 ? -8.74714  -15.63426 20.08317 1.000 17.67246 ? 120 VAL   A C   1 
ATOM   245  O  O   . VAL   A 1 120 ? -7.52429  -15.59604 19.90372 1.000 15.21008 ? 120 VAL   A O   1 
ATOM   246  C  CB  . VAL   A 1 120 ? -9.98046  -17.16718 18.48858 1.000 17.66707 ? 120 VAL   A CB  1 
ATOM   247  C  CG1 . VAL   A 1 120 ? -10.68265 -18.51198 18.35514 1.000 18.09054 ? 120 VAL   A CG1 1 
ATOM   248  C  CG2 . VAL   A 1 120 ? -10.89072 -16.03043 18.03624 1.000 17.38950 ? 120 VAL   A CG2 1 
ATOM   249  N  N   . ILE   A 1 121 ? -9.43935  -14.54159 20.41412 1.000 14.66620 ? 121 ILE   A N   1 
ATOM   250  C  CA  . ILE   A 1 121 ? -8.75562  -13.25896 20.55259 1.000 14.66621 ? 121 ILE   A CA  1 
ATOM   251  C  C   . ILE   A 1 121 ? -7.93431  -13.22909 21.83546 1.000 13.74127 ? 121 ILE   A C   1 
ATOM   252  O  O   . ILE   A 1 121 ? -6.78574  -12.76969 21.84075 1.000 18.55380 ? 121 ILE   A O   1 
ATOM   253  C  CB  . ILE   A 1 121 ? -9.76835  -12.09993 20.48455 1.000 16.19787 ? 121 ILE   A CB  1 
ATOM   254  C  CG1 . ILE   A 1 121 ? -10.13343 -11.80805 19.02479 1.000 12.93476 ? 121 ILE   A CG1 1 
ATOM   255  C  CG2 . ILE   A 1 121 ? -9.22719  -10.85451 21.17791 1.000 11.26870 ? 121 ILE   A CG2 1 
ATOM   256  C  CD1 . ILE   A 1 121 ? -11.29745 -10.85914 18.85446 1.000 18.85657 ? 121 ILE   A CD1 1 
ATOM   257  N  N   . MET   A 1 122 ? -8.50048  -13.72511 22.93872 1.000 12.03133 ? 122 MET   A N   1 
ATOM   258  C  CA  . MET   A 1 122 ? -7.73116  -13.85027 24.17361 1.000 11.44677 ? 122 MET   A CA  1 
ATOM   259  C  C   . MET   A 1 122 ? -6.52431  -14.75915 23.97499 1.000 14.43802 ? 122 MET   A C   1 
ATOM   260  O  O   . MET   A 1 122 ? -5.40885  -14.43023 24.39510 1.000 15.64244 ? 122 MET   A O   1 
ATOM   261  C  CB  . MET   A 1 122 ? -8.62201  -14.37890 25.29880 1.000 12.89108 ? 122 MET   A CB  1 
ATOM   262  C  CG  . MET   A 1 122 ? -9.53201  -13.33561 25.92917 1.000 12.70165 ? 122 MET   A CG  1 
ATOM   263  S  SD  . MET   A 1 122 ? -8.66808  -12.26740 27.09813 1.000 15.75655 ? 122 MET   A SD  1 
ATOM   264  C  CE  . MET   A 1 122 ? -8.53671  -13.34657 28.52105 1.000 7.28306  ? 122 MET   A CE  1 
ATOM   265  N  N   . HIS   A 1 123 ? -6.73049  -15.91070 23.33057 1.000 13.31365 ? 123 HIS   A N   1 
ATOM   266  C  CA  . HIS   A 1 123 ? -5.62623  -16.83376 23.08570 1.000 17.06191 ? 123 HIS   A CA  1 
ATOM   267  C  C   . HIS   A 1 123 ? -4.53432  -16.17134 22.25569 1.000 18.63020 ? 123 HIS   A C   1 
ATOM   268  O  O   . HIS   A 1 123 ? -3.34465  -16.27341 22.57760 1.000 20.75459 ? 123 HIS   A O   1 
ATOM   269  C  CB  . HIS   A 1 123 ? -6.13924  -18.09493 22.38961 1.000 21.52827 ? 123 HIS   A CB  1 
ATOM   270  C  CG  . HIS   A 1 123 ? -5.10779  -19.17201 22.25419 1.000 28.81052 ? 123 HIS   A CG  1 
ATOM   271  N  ND1 . HIS   A 1 123 ? -5.25657  -20.24255 21.39879 1.000 27.84090 ? 123 HIS   A ND1 1 
ATOM   272  C  CD2 . HIS   A 1 123 ? -3.91484  -19.34651 22.87066 1.000 27.40018 ? 123 HIS   A CD2 1 
ATOM   273  C  CE1 . HIS   A 1 123 ? -4.19794  -21.02741 21.49072 1.000 33.89699 ? 123 HIS   A CE1 1 
ATOM   274  N  NE2 . HIS   A 1 123 ? -3.36905  -20.50656 22.37742 1.000 26.92915 ? 123 HIS   A NE2 1 
ATOM   275  N  N   . THR   A 1 124 ? -4.92526  -15.48223 21.18045 1.000 17.69408 ? 124 THR   A N   1 
ATOM   276  C  CA  . THR   A 1 124 ? -3.94987  -14.78652 20.34682 1.000 20.60079 ? 124 THR   A CA  1 
ATOM   277  C  C   . THR   A 1 124 ? -3.18069  -13.74480 21.14891 1.000 19.54886 ? 124 THR   A C   1 
ATOM   278  O  O   . THR   A 1 124 ? -1.95497  -13.63442 21.02566 1.000 21.92741 ? 124 THR   A O   1 
ATOM   279  C  CB  . THR   A 1 124 ? -4.65028  -14.12749 19.15724 1.000 18.90159 ? 124 THR   A CB  1 
ATOM   280  O  OG1 . THR   A 1 124 ? -5.36216  -15.11871 18.40623 1.000 18.20057 ? 124 THR   A OG1 1 
ATOM   281  C  CG2 . THR   A 1 124 ? -3.63606  -13.44353 18.25253 1.000 14.74152 ? 124 THR   A CG2 1 
ATOM   282  N  N   . ILE   A 1 125 ? -3.88360  -12.98021 21.98639 1.000 17.10909 ? 125 ILE   A N   1 
ATOM   283  C  CA  . ILE   A 1 125 ? -3.24048  -11.90701 22.73732 1.000 17.61644 ? 125 ILE   A CA  1 
ATOM   284  C  C   . ILE   A 1 125 ? -2.29899  -12.47405 23.79389 1.000 18.36377 ? 125 ILE   A C   1 
ATOM   285  O  O   . ILE   A 1 125 ? -1.20616  -11.93943 24.01949 1.000 20.65499 ? 125 ILE   A O   1 
ATOM   286  C  CB  . ILE   A 1 125 ? -4.30868  -10.98255 23.34945 1.000 17.95583 ? 125 ILE   A CB  1 
ATOM   287  C  CG1 . ILE   A 1 125 ? -4.94917  -10.13031 22.25233 1.000 18.89598 ? 125 ILE   A CG1 1 
ATOM   288  C  CG2 . ILE   A 1 125 ? -3.71218  -10.10290 24.43782 1.000 15.13702 ? 125 ILE   A CG2 1 
ATOM   289  C  CD1 . ILE   A 1 125 ? -6.18093  -9.38402  22.69712 1.000 16.42136 ? 125 ILE   A CD1 1 
ATOM   290  N  N   . PHE   A 1 126 ? -2.69753  -13.56570 24.45248 1.000 17.66252 ? 126 PHE   A N   1 
ATOM   291  C  CA  . PHE   A 1 126 ? -1.81790  -14.19259 25.43542 1.000 18.14648 ? 126 PHE   A CA  1 
ATOM   292  C  C   . PHE   A 1 126 ? -0.53841  -14.70073 24.78300 1.000 21.44586 ? 126 PHE   A C   1 
ATOM   293  O  O   . PHE   A 1 126 ? 0.55866   -14.52261 25.32632 1.000 21.42796 ? 126 PHE   A O   1 
ATOM   294  C  CB  . PHE   A 1 126 ? -2.55134  -15.32828 26.14984 1.000 18.25822 ? 126 PHE   A CB  1 
ATOM   295  C  CG  . PHE   A 1 126 ? -3.33655  -14.88154 27.35210 1.000 15.00808 ? 126 PHE   A CG  1 
ATOM   296  C  CD1 . PHE   A 1 126 ? -4.31420  -13.90775 27.23589 1.000 13.32842 ? 126 PHE   A CD1 1 
ATOM   297  C  CD2 . PHE   A 1 126 ? -3.09784  -15.43860 28.59878 1.000 14.53093 ? 126 PHE   A CD2 1 
ATOM   298  C  CE1 . PHE   A 1 126 ? -5.03657  -13.49365 28.33965 1.000 10.53682 ? 126 PHE   A CE1 1 
ATOM   299  C  CE2 . PHE   A 1 126 ? -3.81813  -15.02939 29.70788 1.000 11.83535 ? 126 PHE   A CE2 1 
ATOM   300  C  CZ  . PHE   A 1 126 ? -4.78892  -14.05579 29.57744 1.000 10.90553 ? 126 PHE   A CZ  1 
ATOM   301  N  N   . GLN   A 1 127 ? -0.65931  -15.33317 23.61418 1.000 25.86271 ? 127 GLN   A N   1 
ATOM   302  C  CA  . GLN   A 1 127 ? 0.52499   -15.73313 22.86173 1.000 24.10582 ? 127 GLN   A CA  1 
ATOM   303  C  C   . GLN   A 1 127 ? 1.35700   -14.51972 22.46902 1.000 26.18440 ? 127 GLN   A C   1 
ATOM   304  O  O   . GLN   A 1 127 ? 2.58605   -14.52474 22.60359 1.000 22.99552 ? 127 GLN   A O   1 
ATOM   305  C  CB  . GLN   A 1 127 ? 0.11522   -16.52808 21.62054 1.000 25.83590 ? 127 GLN   A CB  1 
ATOM   306  C  CG  . GLN   A 1 127 ? -0.23744  -17.98796 21.88113 1.000 35.98000 ? 127 GLN   A CG  1 
ATOM   307  C  CD  . GLN   A 1 127 ? 0.91424   -18.77215 22.46592 1.000 43.64107 ? 127 GLN   A CD  1 
ATOM   308  O  OE1 . GLN   A 1 127 ? 2.07433   -18.54879 22.12432 1.000 48.90457 ? 127 GLN   A OE1 1 
ATOM   309  N  NE2 . GLN   A 1 127 ? 0.59821   -19.72309 23.32472 1.000 46.34457 ? 127 GLN   A NE2 1 
ATOM   310  N  N   . GLU   A 1 128 ? 0.69633   -13.46738 21.98088 1.000 26.40086 ? 128 GLU   A N   1 
ATOM   311  C  CA  . GLU   A 1 128 ? 1.40521   -12.27423 21.52805 1.000 25.98814 ? 128 GLU   A CA  1 
ATOM   312  C  C   . GLU   A 1 128 ? 2.23713   -11.66290 22.64907 1.000 25.27619 ? 128 GLU   A C   1 
ATOM   313  O  O   . GLU   A 1 128 ? 3.41685   -11.34342 22.46117 1.000 20.88574 ? 128 GLU   A O   1 
ATOM   314  C  CB  . GLU   A 1 128 ? 0.40292   -11.25555 20.98158 1.000 26.14516 ? 128 GLU   A CB  1 
ATOM   315  C  CG  . GLU   A 1 128 ? 1.00940   -9.92180  20.57442 1.000 33.67332 ? 128 GLU   A CG  1 
ATOM   316  C  CD  . GLU   A 1 128 ? 1.71054   -9.97250  19.22839 1.000 35.83446 ? 128 GLU   A CD  1 
ATOM   317  O  OE1 . GLU   A 1 128 ? 2.14490   -8.90442  18.74701 1.000 35.51036 ? 128 GLU   A OE1 1 
ATOM   318  O  OE2 . GLU   A 1 128 ? 1.82321   -11.07278 18.64732 1.000 33.71775 ? 128 GLU   A OE2 1 
ATOM   319  N  N   . ARG   A 1 129 ? 1.63975   -11.49585 23.82493 1.000 19.60394 ? 129 ARG   A N   1 
ATOM   320  C  CA  . ARG   A 1 129 ? 2.32697   -10.91090 24.96653 1.000 20.19279 ? 129 ARG   A CA  1 
ATOM   321  C  C   . ARG   A 1 129 ? 3.13935   -11.92950 25.75597 1.000 18.39646 ? 129 ARG   A C   1 
ATOM   322  O  O   . ARG   A 1 129 ? 3.66945   -11.58603 26.81763 1.000 17.72777 ? 129 ARG   A O   1 
ATOM   323  C  CB  . ARG   A 1 129 ? 1.32118   -10.21563 25.88701 1.000 19.48208 ? 129 ARG   A CB  1 
ATOM   324  C  CG  . ARG   A 1 129 ? 0.60862   -9.04674  25.22802 1.000 22.67613 ? 129 ARG   A CG  1 
ATOM   325  C  CD  . ARG   A 1 129 ? -0.22248  -8.25703  26.22398 1.000 18.03216 ? 129 ARG   A CD  1 
ATOM   326  N  NE  . ARG   A 1 129 ? -0.77095  -7.04513  25.62277 1.000 14.67717 ? 129 ARG   A NE  1 
ATOM   327  C  CZ  . ARG   A 1 129 ? -0.12214  -5.88782  25.54925 1.000 23.16945 ? 129 ARG   A CZ  1 
ATOM   328  N  NH1 . ARG   A 1 129 ? 1.10373   -5.77995  26.04372 1.000 22.34009 ? 129 ARG   A NH1 1 
ATOM   329  N  NH2 . ARG   A 1 129 ? -0.69884  -4.83799  24.98059 1.000 19.33843 ? 129 ARG   A NH2 1 
ATOM   330  N  N   . ASP   A 1 130 ? 3.24461   -13.16774 25.26432 1.000 23.69756 ? 130 ASP   A N   1 
ATOM   331  C  CA  . ASP   A 1 130 ? 4.05221   -14.21307 25.89720 1.000 23.68446 ? 130 ASP   A CA  1 
ATOM   332  C  C   . ASP   A 1 130 ? 3.57880   -14.50754 27.31979 1.000 26.86382 ? 130 ASP   A C   1 
ATOM   333  O  O   . ASP   A 1 130 ? 4.37885   -14.84203 28.19735 1.000 22.00207 ? 130 ASP   A O   1 
ATOM   334  C  CB  . ASP   A 1 130 ? 5.53927   -13.83929 25.88737 1.000 26.65820 ? 130 ASP   A CB  1 
ATOM   335  C  CG  . ASP   A 1 130 ? 6.44896   -15.05083 25.84344 1.000 29.69806 ? 130 ASP   A CG  1 
ATOM   336  O  OD1 . ASP   A 1 130 ? 5.95878   -16.15347 25.52364 1.000 24.28352 ? 130 ASP   A OD1 1 
ATOM   337  O  OD2 . ASP   A 1 130 ? 7.65717   -14.89679 26.11976 1.000 34.68464 ? 130 ASP   A OD2 1 
ATOM   338  N  N   . LEU   A 1 131 ? 2.26745   -14.39661 27.55201 1.000 20.54893 ? 131 LEU   A N   1 
ATOM   339  C  CA  . LEU   A 1 131 ? 1.72503   -14.50146 28.90272 1.000 19.08364 ? 131 LEU   A CA  1 
ATOM   340  C  C   . LEU   A 1 131 ? 1.65894   -15.93874 29.40364 1.000 21.93318 ? 131 LEU   A C   1 
ATOM   341  O  O   . LEU   A 1 131 ? 1.71463   -16.16440 30.61768 1.000 19.71249 ? 131 LEU   A O   1 
ATOM   342  C  CB  . LEU   A 1 131 ? 0.33477   -13.86765 28.95935 1.000 19.94212 ? 131 LEU   A CB  1 
ATOM   343  C  CG  . LEU   A 1 131 ? 0.29630   -12.34052 28.89809 1.000 21.09558 ? 131 LEU   A CG  1 
ATOM   344  C  CD1 . LEU   A 1 131 ? -1.12718  -11.84970 28.69681 1.000 17.00161 ? 131 LEU   A CD1 1 
ATOM   345  C  CD2 . LEU   A 1 131 ? 0.89693   -11.74414 30.16109 1.000 13.08059 ? 131 LEU   A CD2 1 
ATOM   346  N  N   . LEU   A 1 132 ? 1.52663   -16.91715 28.50503 1.000 22.98946 ? 132 LEU   A N   1 
ATOM   347  C  CA  . LEU   A 1 132 ? 1.51032   -18.30916 28.94459 1.000 21.88355 ? 132 LEU   A CA  1 
ATOM   348  C  C   . LEU   A 1 132 ? 2.84687   -18.70769 29.55512 1.000 23.12284 ? 132 LEU   A C   1 
ATOM   349  O  O   . LEU   A 1 132 ? 2.88990   -19.45246 30.54049 1.000 25.72371 ? 132 LEU   A O   1 
ATOM   350  C  CB  . LEU   A 1 132 ? 1.15283   -19.23049 27.77924 1.000 25.32826 ? 132 LEU   A CB  1 
ATOM   351  C  CG  . LEU   A 1 132 ? -0.26280  -19.04230 27.23449 1.000 27.86343 ? 132 LEU   A CG  1 
ATOM   352  C  CD1 . LEU   A 1 132 ? -0.24305  -18.14696 26.00849 1.000 21.72028 ? 132 LEU   A CD1 1 
ATOM   353  C  CD2 . LEU   A 1 132 ? -0.91651  -20.38279 26.92362 1.000 26.72425 ? 132 LEU   A CD2 1 
ATOM   354  N  N   . LYS   A 1 133 ? 3.94942   -18.21522 28.98916 1.000 21.43301 ? 133 LYS   A N   1 
ATOM   355  C  CA  . LYS   A 1 133 ? 5.26379   -18.52509 29.54114 1.000 24.32012 ? 133 LYS   A CA  1 
ATOM   356  C  C   . LYS   A 1 133 ? 5.52593   -17.73787 30.81746 1.000 22.77194 ? 133 LYS   A C   1 
ATOM   357  O  O   . LYS   A 1 133 ? 6.01210   -18.29145 31.81082 1.000 23.30972 ? 133 LYS   A O   1 
ATOM   358  C  CB  . LYS   A 1 133 ? 6.34989   -18.23960 28.50625 1.000 27.27388 ? 133 LYS   A CB  1 
ATOM   359  C  CG  . LYS   A 1 133 ? 6.54452   -19.35394 27.50621 1.000 37.43743 ? 133 LYS   A CG  1 
ATOM   360  C  CD  . LYS   A 1 133 ? 7.90675   -19.26513 26.84877 1.000 41.56091 ? 133 LYS   A CD  1 
ATOM   361  C  CE  . LYS   A 1 133 ? 8.31898   -20.61664 26.30235 1.000 43.85234 ? 133 LYS   A CE  1 
ATOM   362  N  NZ  . LYS   A 1 133 ? 7.16784   -21.30060 25.65464 1.000 45.46816 ? 133 LYS   A NZ  1 
ATOM   363  N  N   . THR   A 1 134 ? 5.21378   -16.43951 30.80459 1.000 23.01340 ? 134 THR   A N   1 
ATOM   364  C  CA  . THR   A 1 134 ? 5.49715   -15.59154 31.95828 1.000 23.98334 ? 134 THR   A CA  1 
ATOM   365  C  C   . THR   A 1 134 ? 4.79375   -16.10137 33.20870 1.000 25.79724 ? 134 THR   A C   1 
ATOM   366  O  O   . THR   A 1 134 ? 5.36543   -16.08209 34.30542 1.000 28.09394 ? 134 THR   A O   1 
ATOM   367  C  CB  . THR   A 1 134 ? 5.07902   -14.15044 31.66289 1.000 22.56949 ? 134 THR   A CB  1 
ATOM   368  O  OG1 . THR   A 1 134 ? 5.84712   -13.64354 30.56429 1.000 20.90826 ? 134 THR   A OG1 1 
ATOM   369  C  CG2 . THR   A 1 134 ? 5.29699   -13.26498 32.88238 1.000 18.08326 ? 134 THR   A CG2 1 
ATOM   370  N  N   . PHE   A 1 135 ? 3.56028   -16.57777 33.06314 1.000 20.90598 ? 135 PHE   A N   1 
ATOM   371  C  CA  . PHE   A 1 135 ? 2.76119   -17.00395 34.20128 1.000 26.62901 ? 135 PHE   A CA  1 
ATOM   372  C  C   . PHE   A 1 135 ? 2.50494   -18.50360 34.21319 1.000 22.72774 ? 135 PHE   A C   1 
ATOM   373  O  O   . PHE   A 1 135 ? 1.63973   -18.96629 34.96430 1.000 20.72535 ? 135 PHE   A O   1 
ATOM   374  C  CB  . PHE   A 1 135 ? 1.44982   -16.22019 34.22680 1.000 24.26126 ? 135 PHE   A CB  1 
ATOM   375  C  CG  . PHE   A 1 135 ? 1.64498   -14.76646 34.52461 1.000 23.05764 ? 135 PHE   A CG  1 
ATOM   376  C  CD1 . PHE   A 1 135 ? 1.96129   -14.35505 35.80674 1.000 23.94013 ? 135 PHE   A CD1 1 
ATOM   377  C  CD2 . PHE   A 1 135 ? 1.55950   -13.81607 33.52148 1.000 22.54498 ? 135 PHE   A CD2 1 
ATOM   378  C  CE1 . PHE   A 1 135 ? 2.16298   -13.02254 36.09198 1.000 23.20390 ? 135 PHE   A CE1 1 
ATOM   379  C  CE2 . PHE   A 1 135 ? 1.76118   -12.47825 33.80094 1.000 21.53867 ? 135 PHE   A CE2 1 
ATOM   380  C  CZ  . PHE   A 1 135 ? 2.06354   -12.08195 35.08867 1.000 19.22463 ? 135 PHE   A CZ  1 
ATOM   381  N  N   . LYS   A 1 136 ? 3.24980   -19.26928 33.41198 1.000 21.82038 ? 136 LYS   A N   1 
ATOM   382  C  CA  . LYS   A 1 136 ? 3.18473   -20.73167 33.41399 1.000 24.16838 ? 136 LYS   A CA  1 
ATOM   383  C  C   . LYS   A 1 136 ? 1.74201   -21.22053 33.30570 1.000 20.75251 ? 136 LYS   A C   1 
ATOM   384  O  O   . LYS   A 1 136 ? 1.31301   -22.13302 34.01540 1.000 21.87882 ? 136 LYS   A O   1 
ATOM   385  C  CB  . LYS   A 1 136 ? 3.88145   -21.30518 34.65080 1.000 19.75845 ? 136 LYS   A CB  1 
ATOM   386  C  CG  . LYS   A 1 136 ? 5.29446   -20.75373 34.86864 1.000 30.91658 ? 136 LYS   A CG  1 
ATOM   387  C  CD  . LYS   A 1 136 ? 5.99812   -21.42612 36.04406 1.000 34.92409 ? 136 LYS   A CD  1 
ATOM   388  C  CE  . LYS   A 1 136 ? 7.10943   -20.55283 36.63028 1.000 42.12077 ? 136 LYS   A CE  1 
ATOM   389  N  NZ  . LYS   A 1 136 ? 8.20710   -20.24161 35.66971 1.000 38.20622 ? 136 LYS   A NZ  1 
ATOM   390  N  N   . ILE   A 1 137 ? 0.98416   -20.59060 32.41237 1.000 21.63710 ? 137 ILE   A N   1 
ATOM   391  C  CA  . ILE   A 1 137 ? -0.40537  -20.95636 32.15007 1.000 20.75030 ? 137 ILE   A CA  1 
ATOM   392  C  C   . ILE   A 1 137 ? -0.42510  -22.12157 31.16899 1.000 20.33049 ? 137 ILE   A C   1 
ATOM   393  O  O   . ILE   A 1 137 ? 0.02982   -21.97019 30.02573 1.000 24.51313 ? 137 ILE   A O   1 
ATOM   394  C  CB  . ILE   A 1 137 ? -1.20684  -19.76898 31.59059 1.000 22.88734 ? 137 ILE   A CB  1 
ATOM   395  C  CG1 . ILE   A 1 137 ? -1.09893  -18.54769 32.50544 1.000 25.34292 ? 137 ILE   A CG1 1 
ATOM   396  C  CG2 . ILE   A 1 137 ? -2.66747  -20.15797 31.38241 1.000 17.48943 ? 137 ILE   A CG2 1 
ATOM   397  C  CD1 . ILE   A 1 137 ? -1.80452  -17.32208 31.95453 1.000 23.96005 ? 137 ILE   A CD1 1 
ATOM   398  N  N   . PRO   A 1 138 ? -0.92903  -23.29066 31.55944 1.000 22.44598 ? 138 PRO   A N   1 
ATOM   399  C  CA  . PRO   A 1 138 ? -1.07686  -24.38144 30.58963 1.000 23.11220 ? 138 PRO   A CA  1 
ATOM   400  C  C   . PRO   A 1 138 ? -2.07730  -23.99909 29.51034 1.000 25.85067 ? 138 PRO   A C   1 
ATOM   401  O  O   . PRO   A 1 138 ? -3.14200  -23.44619 29.79485 1.000 25.71643 ? 138 PRO   A O   1 
ATOM   402  C  CB  . PRO   A 1 138 ? -1.58055  -25.55358 31.44097 1.000 26.94423 ? 138 PRO   A CB  1 
ATOM   403  C  CG  . PRO   A 1 138 ? -1.25391  -25.17845 32.85860 1.000 22.78412 ? 138 PRO   A CG  1 
ATOM   404  C  CD  . PRO   A 1 138 ? -1.35306  -23.68845 32.91083 1.000 24.01011 ? 138 PRO   A CD  1 
ATOM   405  N  N   . VAL   A 1 139 ? -1.72105  -24.29421 28.25769 1.000 23.56352 ? 139 VAL   A N   1 
ATOM   406  C  CA  . VAL   A 1 139 ? -2.54369  -23.85108 27.13499 1.000 23.16968 ? 139 VAL   A CA  1 
ATOM   407  C  C   . VAL   A 1 139 ? -3.92452  -24.49390 27.19286 1.000 21.46152 ? 139 VAL   A C   1 
ATOM   408  O  O   . VAL   A 1 139 ? -4.93344  -23.85710 26.86706 1.000 20.49970 ? 139 VAL   A O   1 
ATOM   409  C  CB  . VAL   A 1 139 ? -1.82972  -24.13207 25.79710 1.000 29.24321 ? 139 VAL   A CB  1 
ATOM   410  C  CG1 . VAL   A 1 139 ? -1.72187  -25.62988 25.52578 1.000 27.08417 ? 139 VAL   A CG1 1 
ATOM   411  C  CG2 . VAL   A 1 139 ? -2.54394  -23.42182 24.65463 1.000 31.18905 ? 139 VAL   A CG2 1 
ATOM   412  N  N   . ASP   A 1 140 ? -3.99864  -25.75326 27.63205 1.000 21.83741 ? 140 ASP   A N   1 
ATOM   413  C  CA  . ASP   A 1 140 ? -5.29100  -26.42391 27.71076 1.000 20.54165 ? 140 ASP   A CA  1 
ATOM   414  C  C   . ASP   A 1 140 ? -6.15449  -25.83650 28.81803 1.000 21.51477 ? 140 ASP   A C   1 
ATOM   415  O  O   . ASP   A 1 140 ? -7.38072  -25.76713 28.67640 1.000 19.32067 ? 140 ASP   A O   1 
ATOM   416  C  CB  . ASP   A 1 140 ? -5.09219  -27.92541 27.91704 1.000 25.44348 ? 140 ASP   A CB  1 
ATOM   417  C  CG  . ASP   A 1 140 ? -4.29693  -28.24265 29.16655 1.000 26.47106 ? 140 ASP   A CG  1 
ATOM   418  O  OD1 . ASP   A 1 140 ? -3.08121  -27.95721 29.19105 1.000 33.53789 ? 140 ASP   A OD1 1 
ATOM   419  O  OD2 . ASP   A 1 140 ? -4.88792  -28.78400 30.12392 1.000 34.72584 ? 140 ASP   A OD2 1 
ATOM   420  N  N   . THR   A 1 141 ? -5.53581  -25.40534 29.91898 1.000 20.34930 ? 141 THR   A N   1 
ATOM   421  C  CA  . THR   A 1 141 ? -6.27947  -24.70141 30.95720 1.000 20.70235 ? 141 THR   A CA  1 
ATOM   422  C  C   . THR   A 1 141 ? -6.79704  -23.36290 30.44718 1.000 18.02128 ? 141 THR   A C   1 
ATOM   423  O  O   . THR   A 1 141 ? -7.95264  -23.00043 30.69841 1.000 18.93264 ? 141 THR   A O   1 
ATOM   424  C  CB  . THR   A 1 141 ? -5.39652  -24.49516 32.18679 1.000 21.62488 ? 141 THR   A CB  1 
ATOM   425  O  OG1 . THR   A 1 141 ? -4.81429  -25.74513 32.57678 1.000 23.90683 ? 141 THR   A OG1 1 
ATOM   426  C  CG2 . THR   A 1 141 ? -6.21643  -23.93995 33.33850 1.000 20.39709 ? 141 THR   A CG2 1 
ATOM   427  N  N   . LEU   A 1 142 ? -5.95282  -22.61688 29.73064 1.000 17.57097 ? 142 LEU   A N   1 
ATOM   428  C  CA  . LEU   A 1 142 ? -6.37516  -21.33928 29.16659 1.000 20.42407 ? 142 LEU   A CA  1 
ATOM   429  C  C   . LEU   A 1 142 ? -7.57590  -21.51661 28.24695 1.000 20.18933 ? 142 LEU   A C   1 
ATOM   430  O  O   . LEU   A 1 142 ? -8.58238  -20.81088 28.37727 1.000 20.55286 ? 142 LEU   A O   1 
ATOM   431  C  CB  . LEU   A 1 142 ? -5.21331  -20.69149 28.41325 1.000 14.73528 ? 142 LEU   A CB  1 
ATOM   432  C  CG  . LEU   A 1 142 ? -5.51788  -19.34845 27.74876 1.000 16.67868 ? 142 LEU   A CG  1 
ATOM   433  C  CD1 . LEU   A 1 142 ? -6.01651  -18.35108 28.78183 1.000 13.30877 ? 142 LEU   A CD1 1 
ATOM   434  C  CD2 . LEU   A 1 142 ? -4.29605  -18.80935 27.02090 1.000 14.28724 ? 142 LEU   A CD2 1 
ATOM   435  N  N   . ILE   A 1 143 ? -7.48833  -22.46635 27.31291 1.000 17.12215 ? 143 ILE   A N   1 
ATOM   436  C  CA  . ILE   A 1 143 ? -8.57898  -22.68883 26.36747 1.000 16.19632 ? 143 ILE   A CA  1 
ATOM   437  C  C   . ILE   A 1 143 ? -9.84222  -23.12463 27.09868 1.000 18.42682 ? 143 ILE   A C   1 
ATOM   438  O  O   . ILE   A 1 143 ? -10.94861 -22.67022 26.78147 1.000 20.32526 ? 143 ILE   A O   1 
ATOM   439  C  CB  . ILE   A 1 143 ? -8.15838  -23.71746 25.30089 1.000 20.87745 ? 143 ILE   A CB  1 
ATOM   440  C  CG1 . ILE   A 1 143 ? -6.95249  -23.20393 24.51183 1.000 25.03681 ? 143 ILE   A CG1 1 
ATOM   441  C  CG2 . ILE   A 1 143 ? -9.31850  -24.03115 24.36721 1.000 19.85880 ? 143 ILE   A CG2 1 
ATOM   442  C  CD1 . ILE   A 1 143 ? -7.15545  -21.83119 23.91240 1.000 27.37652 ? 143 ILE   A CD1 1 
ATOM   443  N  N   . THR   A 1 144 ? -9.69919  -24.00578 28.09257 1.000 17.44841 ? 144 THR   A N   1 
ATOM   444  C  CA  . THR   A 1 144 ? -10.86747 -24.49574 28.81812 1.000 18.01547 ? 144 THR   A CA  1 
ATOM   445  C  C   . THR   A 1 144 ? -11.57121 -23.36880 29.56483 1.000 16.59678 ? 144 THR   A C   1 
ATOM   446  O  O   . THR   A 1 144 ? -12.80459 -23.27837 29.54334 1.000 15.42048 ? 144 THR   A O   1 
ATOM   447  C  CB  . THR   A 1 144 ? -10.46377 -25.60936 29.78566 1.000 20.77294 ? 144 THR   A CB  1 
ATOM   448  O  OG1 . THR   A 1 144 ? -9.81797  -26.66381 29.06207 1.000 20.87525 ? 144 THR   A OG1 1 
ATOM   449  C  CG2 . THR   A 1 144 ? -11.69051 -26.16990 30.49396 1.000 15.57463 ? 144 THR   A CG2 1 
ATOM   450  N  N   . TYR   A 1 145 ? -10.80889 -22.49593 30.22852 1.000 16.35961 ? 145 TYR   A N   1 
ATOM   451  C  CA  . TYR   A 1 145 ? -11.43264 -21.38354 30.93880 1.000 15.45491 ? 145 TYR   A CA  1 
ATOM   452  C  C   . TYR   A 1 145 ? -12.09280 -20.41136 29.96943 1.000 13.75044 ? 145 TYR   A C   1 
ATOM   453  O  O   . TYR   A 1 145 ? -13.22477 -19.96841 30.19585 1.000 16.08872 ? 145 TYR   A O   1 
ATOM   454  C  CB  . TYR   A 1 145 ? -10.41200 -20.64558 31.80539 1.000 13.60025 ? 145 TYR   A CB  1 
ATOM   455  C  CG  . TYR   A 1 145 ? -10.99973 -19.39414 32.41864 1.000 16.32639 ? 145 TYR   A CG  1 
ATOM   456  C  CD1 . TYR   A 1 145 ? -11.80347 -19.46785 33.54774 1.000 13.81085 ? 145 TYR   A CD1 1 
ATOM   457  C  CD2 . TYR   A 1 145 ? -10.77959 -18.14352 31.85097 1.000 15.61813 ? 145 TYR   A CD2 1 
ATOM   458  C  CE1 . TYR   A 1 145 ? -12.35935 -18.33310 34.10427 1.000 16.39287 ? 145 TYR   A CE1 1 
ATOM   459  C  CE2 . TYR   A 1 145 ? -11.33366 -17.00176 32.40077 1.000 11.70596 ? 145 TYR   A CE2 1 
ATOM   460  C  CZ  . TYR   A 1 145 ? -12.12093 -17.10286 33.52818 1.000 13.69519 ? 145 TYR   A CZ  1 
ATOM   461  O  OH  . TYR   A 1 145 ? -12.67493 -15.97194 34.08380 1.000 13.89089 ? 145 TYR   A OH  1 
ATOM   462  N  N   . LEU   A 1 146 ? -11.39169 -20.05613 28.88913 1.000 13.39168 ? 146 LEU   A N   1 
ATOM   463  C  CA  . LEU   A 1 146 ? -11.92661 -19.07629 27.94829 1.000 15.25313 ? 146 LEU   A CA  1 
ATOM   464  C  C   . LEU   A 1 146 ? -13.23909 -19.54979 27.33842 1.000 17.01760 ? 146 LEU   A C   1 
ATOM   465  O  O   . LEU   A 1 146 ? -14.16803 -18.75462 27.15441 1.000 15.35682 ? 146 LEU   A O   1 
ATOM   466  C  CB  . LEU   A 1 146 ? -10.90030 -18.78194 26.85457 1.000 15.73782 ? 146 LEU   A CB  1 
ATOM   467  C  CG  . LEU   A 1 146 ? -9.65316  -18.02188 27.30910 1.000 15.44113 ? 146 LEU   A CG  1 
ATOM   468  C  CD1 . LEU   A 1 146 ? -8.63006  -17.94560 26.18651 1.000 13.51062 ? 146 LEU   A CD1 1 
ATOM   469  C  CD2 . LEU   A 1 146 ? -10.02477 -16.63275 27.80291 1.000 18.61421 ? 146 LEU   A CD2 1 
ATOM   470  N  N   . MET   A 1 147 ? -13.34097 -20.84360 27.02752 1.000 16.92689 ? 147 MET   A N   1 
ATOM   471  C  CA  . MET   A 1 147 ? -14.57905 -21.35739 26.45206 1.000 21.65803 ? 147 MET   A CA  1 
ATOM   472  C  C   . MET   A 1 147 ? -15.69833 -21.38244 27.48587 1.000 16.67289 ? 147 MET   A C   1 
ATOM   473  O  O   . MET   A 1 147 ? -16.84804 -21.05702 27.16821 1.000 15.94553 ? 147 MET   A O   1 
ATOM   474  C  CB  . MET   A 1 147 ? -14.34865 -22.74728 25.85886 1.000 18.48545 ? 147 MET   A CB  1 
ATOM   475  C  CG  . MET   A 1 147 ? -13.40272 -22.74592 24.66549 1.000 22.90946 ? 147 MET   A CG  1 
ATOM   476  S  SD  . MET   A 1 147 ? -13.32714 -24.32121 23.79264 1.000 37.04290 ? 147 MET   A SD  1 
ATOM   477  C  CE  . MET   A 1 147 ? -14.73279 -24.16539 22.69422 1.000 35.57038 ? 147 MET   A CE  1 
ATOM   478  N  N   . THR   A 1 148 ? -15.38356 -21.75895 28.72875 1.000 14.07865 ? 148 THR   A N   1 
ATOM   479  C  CA  . THR   A 1 148 ? -16.38236 -21.68851 29.79108 1.000 15.86539 ? 148 THR   A CA  1 
ATOM   480  C  C   . THR   A 1 148 ? -16.80572 -20.24776 30.04584 1.000 18.13263 ? 148 THR   A C   1 
ATOM   481  O  O   . THR   A 1 148 ? -17.99755 -19.96089 30.21198 1.000 16.07161 ? 148 THR   A O   1 
ATOM   482  C  CB  . THR   A 1 148 ? -15.83950 -22.31523 31.07581 1.000 21.47124 ? 148 THR   A CB  1 
ATOM   483  O  OG1 . THR   A 1 148 ? -15.19246 -23.55678 30.77276 1.000 25.60049 ? 148 THR   A OG1 1 
ATOM   484  C  CG2 . THR   A 1 148 ? -16.97240 -22.56639 32.06048 1.000 14.52712 ? 148 THR   A CG2 1 
ATOM   485  N  N   . LEU   A 1 149 ? -15.83920 -19.32798 30.08076 1.000 16.63601 ? 149 LEU   A N   1 
ATOM   486  C  CA  . LEU   A 1 149 ? -16.15824 -17.91473 30.25256 1.000 13.97785 ? 149 LEU   A CA  1 
ATOM   487  C  C   . LEU   A 1 149 ? -17.01681 -17.40558 29.10210 1.000 15.23737 ? 149 LEU   A C   1 
ATOM   488  O  O   . LEU   A 1 149 ? -18.00718 -16.69634 29.31561 1.000 14.14305 ? 149 LEU   A O   1 
ATOM   489  C  CB  . LEU   A 1 149 ? -14.86986 -17.09948 30.36237 1.000 15.86548 ? 149 LEU   A CB  1 
ATOM   490  C  CG  . LEU   A 1 149 ? -15.04676 -15.58058 30.39595 1.000 16.36329 ? 149 LEU   A CG  1 
ATOM   491  C  CD1 . LEU   A 1 149 ? -15.77176 -15.15725 31.66272 1.000 11.01939 ? 149 LEU   A CD1 1 
ATOM   492  C  CD2 . LEU   A 1 149 ? -13.70575 -14.87443 30.27510 1.000 13.47140 ? 149 LEU   A CD2 1 
ATOM   493  N  N   . GLU   A 1 150 ? -16.64872 -17.76199 27.86911 1.000 12.66212 ? 150 GLU   A N   1 
ATOM   494  C  CA  . GLU   A 1 150 ? -17.42883 -17.33914 26.71136 1.000 16.43351 ? 150 GLU   A CA  1 
ATOM   495  C  C   . GLU   A 1 150 ? -18.84081 -17.90785 26.76057 1.000 16.75705 ? 150 GLU   A C   1 
ATOM   496  O  O   . GLU   A 1 150 ? -19.80700 -17.21565 26.41855 1.000 17.46108 ? 150 GLU   A O   1 
ATOM   497  C  CB  . GLU   A 1 150 ? -16.72216 -17.75933 25.42281 1.000 15.91559 ? 150 GLU   A CB  1 
ATOM   498  C  CG  . GLU   A 1 150 ? -17.37574 -17.23422 24.16010 1.000 18.05261 ? 150 GLU   A CG  1 
ATOM   499  C  CD  . GLU   A 1 150 ? -16.36903 -16.92762 23.07245 1.000 18.94223 ? 150 GLU   A CD  1 
ATOM   500  O  OE1 . GLU   A 1 150 ? -15.27497 -17.53216 23.07734 1.000 14.74525 ? 150 GLU   A OE1 1 
ATOM   501  O  OE2 . GLU   A 1 150 ? -16.66958 -16.06960 22.21889 1.000 16.05057 ? 150 GLU   A OE2 1 
ATOM   502  N  N   . ASP   A 1 151 ? -18.97953 -19.16669 27.19200 1.000 15.07657 ? 151 ASP   A N   1 
ATOM   503  C  CA  . ASP   A 1 151 ? -20.30174 -19.77441 27.31628 1.000 17.61724 ? 151 ASP   A CA  1 
ATOM   504  C  C   . ASP   A 1 151 ? -21.22394 -18.94793 28.19927 1.000 16.08532 ? 151 ASP   A C   1 
ATOM   505  O  O   . ASP   A 1 151 ? -22.43194 -18.88103 27.94454 1.000 18.06533 ? 151 ASP   A O   1 
ATOM   506  C  CB  . ASP   A 1 151 ? -20.19060 -21.18834 27.88743 1.000 21.35995 ? 151 ASP   A CB  1 
ATOM   507  C  CG  . ASP   A 1 151 ? -19.62974 -22.18060 26.89391 1.000 26.54184 ? 151 ASP   A CG  1 
ATOM   508  O  OD1 . ASP   A 1 151 ? -19.46696 -21.81953 25.71007 1.000 26.45901 ? 151 ASP   A OD1 1 
ATOM   509  O  OD2 . ASP   A 1 151 ? -19.36014 -23.33013 27.30141 1.000 30.12850 ? 151 ASP   A OD2 1 
ATOM   510  N  N   . HIS   A 1 152 ? -20.68164 -18.31689 29.23708 1.000 15.56296 ? 152 HIS   A N   1 
ATOM   511  C  CA  . HIS   A 1 152 ? -21.51534 -17.61939 30.20448 1.000 17.61203 ? 152 HIS   A CA  1 
ATOM   512  C  C   . HIS   A 1 152 ? -21.86380 -16.20023 29.78162 1.000 15.12654 ? 152 HIS   A C   1 
ATOM   513  O  O   . HIS   A 1 152 ? -22.59252 -15.51990 30.50899 1.000 16.08354 ? 152 HIS   A O   1 
ATOM   514  C  CB  . HIS   A 1 152 ? -20.83841 -17.63382 31.57447 1.000 16.00348 ? 152 HIS   A CB  1 
ATOM   515  C  CG  . HIS   A 1 152 ? -20.92402 -18.96241 32.25840 1.000 17.63504 ? 152 HIS   A CG  1 
ATOM   516  N  ND1 . HIS   A 1 152 ? -20.14987 -20.04083 31.88761 1.000 18.48138 ? 152 HIS   A ND1 1 
ATOM   517  C  CD2 . HIS   A 1 152 ? -21.71507 -19.39667 33.26773 1.000 18.29102 ? 152 HIS   A CD2 1 
ATOM   518  C  CE1 . HIS   A 1 152 ? -20.44948 -21.07771 32.64919 1.000 16.21108 ? 152 HIS   A CE1 1 
ATOM   519  N  NE2 . HIS   A 1 152 ? -21.39614 -20.71338 33.49508 1.000 16.65686 ? 152 HIS   A NE2 1 
ATOM   520  N  N   . TYR   A 1 153 ? -21.37239 -15.73969 28.63701 1.000 15.02190 ? 153 TYR   A N   1 
ATOM   521  C  CA  . TYR   A 1 153 ? -22.00505 -14.61897 27.96367 1.000 16.53067 ? 153 TYR   A CA  1 
ATOM   522  C  C   . TYR   A 1 153 ? -23.23791 -15.11986 27.22144 1.000 18.04322 ? 153 TYR   A C   1 
ATOM   523  O  O   . TYR   A 1 153 ? -23.26806 -16.24543 26.71578 1.000 18.30140 ? 153 TYR   A O   1 
ATOM   524  C  CB  . TYR   A 1 153 ? -21.03565 -13.94016 26.99527 1.000 13.25931 ? 153 TYR   A CB  1 
ATOM   525  C  CG  . TYR   A 1 153 ? -20.03537 -13.02805 27.66885 1.000 14.68887 ? 153 TYR   A CG  1 
ATOM   526  C  CD1 . TYR   A 1 153 ? -18.82997 -13.52066 28.15174 1.000 14.69139 ? 153 TYR   A CD1 1 
ATOM   527  C  CD2 . TYR   A 1 153 ? -20.29709 -11.67332 27.82002 1.000 14.15253 ? 153 TYR   A CD2 1 
ATOM   528  C  CE1 . TYR   A 1 153 ? -17.91410 -12.68893 28.76755 1.000 10.83085 ? 153 TYR   A CE1 1 
ATOM   529  C  CE2 . TYR   A 1 153 ? -19.38764 -10.83464 28.43167 1.000 12.96277 ? 153 TYR   A CE2 1 
ATOM   530  C  CZ  . TYR   A 1 153 ? -18.19960 -11.34761 28.90741 1.000 12.36361 ? 153 TYR   A CZ  1 
ATOM   531  O  OH  . TYR   A 1 153 ? -17.28945 -10.51534 29.51884 1.000 14.17408 ? 153 TYR   A OH  1 
ATOM   532  N  N   . HIS   A 1 154 ? -24.26733 -14.28138 27.17341 1.000 15.71198 ? 154 HIS   A N   1 
ATOM   533  C  CA  . HIS   A 1 154 ? -25.55827 -14.68293 26.62913 1.000 20.45848 ? 154 HIS   A CA  1 
ATOM   534  C  C   . HIS   A 1 154 ? -25.56282 -14.48637 25.11852 1.000 23.15085 ? 154 HIS   A C   1 
ATOM   535  O  O   . HIS   A 1 154 ? -25.42644 -13.35837 24.63250 1.000 15.29690 ? 154 HIS   A O   1 
ATOM   536  C  CB  . HIS   A 1 154 ? -26.69154 -13.89321 27.28147 1.000 16.47681 ? 154 HIS   A CB  1 
ATOM   537  C  CG  . HIS   A 1 154 ? -26.83986 -14.15064 28.74918 1.000 20.30623 ? 154 HIS   A CG  1 
ATOM   538  N  ND1 . HIS   A 1 154 ? -28.05829 -14.10782 29.39212 1.000 21.22841 ? 154 HIS   A ND1 1 
ATOM   539  C  CD2 . HIS   A 1 154 ? -25.92316 -14.44968 29.70030 1.000 19.26031 ? 154 HIS   A CD2 1 
ATOM   540  C  CE1 . HIS   A 1 154 ? -27.88647 -14.37289 30.67489 1.000 22.15444 ? 154 HIS   A CE1 1 
ATOM   541  N  NE2 . HIS   A 1 154 ? -26.60000 -14.58334 30.88812 1.000 24.43438 ? 154 HIS   A NE2 1 
ATOM   542  N  N   . ALA   A 1 155 ? -25.72299 -15.58597 24.37950 1.000 18.49265 ? 155 ALA   A N   1 
ATOM   543  C  CA  . ALA   A 1 155 ? -25.78005 -15.51499 22.92585 1.000 21.11293 ? 155 ALA   A CA  1 
ATOM   544  C  C   . ALA   A 1 155 ? -27.05329 -14.85542 22.41550 1.000 20.64629 ? 155 ALA   A C   1 
ATOM   545  O  O   . ALA   A 1 155 ? -27.10117 -14.47653 21.24122 1.000 22.90269 ? 155 ALA   A O   1 
ATOM   546  C  CB  . ALA   A 1 155 ? -25.65082 -16.91539 22.32403 1.000 25.76736 ? 155 ALA   A CB  1 
ATOM   547  N  N   . ASP   A 1 156 ? -28.07789 -14.70768 23.25630 1.000 17.78958 ? 156 ASP   A N   1 
ATOM   548  C  CA  . ASP   A 1 156 ? -29.33614 -14.09603 22.85130 1.000 23.45810 ? 156 ASP   A CA  1 
ATOM   549  C  C   . ASP   A 1 156 ? -29.46456 -12.65228 23.32865 1.000 23.27021 ? 156 ASP   A C   1 
ATOM   550  O  O   . ASP   A 1 156 ? -30.56761 -12.09561 23.31633 1.000 21.44735 ? 156 ASP   A O   1 
ATOM   551  C  CB  . ASP   A 1 156 ? -30.51775 -14.93534 23.34438 1.000 28.42936 ? 156 ASP   A CB  1 
ATOM   552  C  CG  . ASP   A 1 156 ? -30.49536 -15.16072 24.84478 1.000 33.44833 ? 156 ASP   A CG  1 
ATOM   553  O  OD1 . ASP   A 1 156 ? -29.50266 -14.77457 25.49664 1.000 28.13109 ? 156 ASP   A OD1 1 
ATOM   554  O  OD2 . ASP   A 1 156 ? -31.47316 -15.73376 25.37177 1.000 34.28800 ? 156 ASP   A OD2 1 
ATOM   555  N  N   . VAL   A 1 157 ? -28.36176 -12.03981 23.74937 1.000 17.91386 ? 157 VAL   A N   1 
ATOM   556  C  CA  . VAL   A 1 157 ? -28.31350 -10.61922 24.07408 1.000 16.73732 ? 157 VAL   A CA  1 
ATOM   557  C  C   . VAL   A 1 157 ? -27.60440 -9.90506  22.93133 1.000 16.46235 ? 157 VAL   A C   1 
ATOM   558  O  O   . VAL   A 1 157 ? -26.53979 -10.34603 22.47956 1.000 18.50196 ? 157 VAL   A O   1 
ATOM   559  C  CB  . VAL   A 1 157 ? -27.60868 -10.38100 25.42083 1.000 18.41079 ? 157 VAL   A CB  1 
ATOM   560  C  CG1 . VAL   A 1 157 ? -27.19326 -8.93840  25.56016 1.000 21.82505 ? 157 VAL   A CG1 1 
ATOM   561  C  CG2 . VAL   A 1 157 ? -28.52855 -10.77052 26.56817 1.000 19.93661 ? 157 VAL   A CG2 1 
ATOM   562  N  N   . ALA   A 1 158 ? -28.19667 -8.80530  22.45706 1.000 16.56250 ? 158 ALA   A N   1 
ATOM   563  C  CA  . ALA   A 1 158 ? -27.77581 -8.22902  21.18252 1.000 18.86377 ? 158 ALA   A CA  1 
ATOM   564  C  C   . ALA   A 1 158 ? -26.41383 -7.55056  21.28115 1.000 15.61416 ? 158 ALA   A C   1 
ATOM   565  O  O   . ALA   A 1 158 ? -25.59289 -7.66731  20.36423 1.000 13.06597 ? 158 ALA   A O   1 
ATOM   566  C  CB  . ALA   A 1 158 ? -28.82882 -7.24285  20.68021 1.000 19.57472 ? 158 ALA   A CB  1 
ATOM   567  N  N   . TYR   A 1 159 ? -26.15399 -6.82875  22.37076 1.000 13.39575 ? 159 TYR   A N   1 
ATOM   568  C  CA  . TYR   A 1 159 ? -24.90598 -6.09054  22.51995 1.000 15.18761 ? 159 TYR   A CA  1 
ATOM   569  C  C   . TYR   A 1 159 ? -23.98017 -6.72379  23.55097 1.000 13.21940 ? 159 TYR   A C   1 
ATOM   570  O  O   . TYR   A 1 159 ? -22.83327 -7.05211  23.23269 1.000 13.33336 ? 159 TYR   A O   1 
ATOM   571  C  CB  . TYR   A 1 159 ? -25.19538 -4.62448  22.88422 1.000 13.36314 ? 159 TYR   A CB  1 
ATOM   572  C  CG  . TYR   A 1 159 ? -23.95584 -3.76453  23.03190 1.000 14.93652 ? 159 TYR   A CG  1 
ATOM   573  C  CD1 . TYR   A 1 159 ? -23.23993 -3.73509  24.22484 1.000 13.30395 ? 159 TYR   A CD1 1 
ATOM   574  C  CD2 . TYR   A 1 159 ? -23.50265 -2.98030  21.97941 1.000 14.24405 ? 159 TYR   A CD2 1 
ATOM   575  C  CE1 . TYR   A 1 159 ? -22.10683 -2.95747  24.36146 1.000 13.09049 ? 159 TYR   A CE1 1 
ATOM   576  C  CE2 . TYR   A 1 159 ? -22.37088 -2.19563  22.10909 1.000 11.39865 ? 159 TYR   A CE2 1 
ATOM   577  C  CZ  . TYR   A 1 159 ? -21.67762 -2.18919  23.30158 1.000 13.41446 ? 159 TYR   A CZ  1 
ATOM   578  O  OH  . TYR   A 1 159 ? -20.55077 -1.41201  23.43806 1.000 12.43510 ? 159 TYR   A OH  1 
ATOM   579  N  N   . HIS   A 1 160 ? -24.44091 -6.89516  24.79057 1.000 12.44839 ? 160 HIS   A N   1 
ATOM   580  C  CA  . HIS   A 1 160 ? -23.57241 -7.33483  25.88343 1.000 11.82026 ? 160 HIS   A CA  1 
ATOM   581  C  C   . HIS   A 1 160 ? -23.36230 -8.85112  25.84344 1.000 13.38465 ? 160 HIS   A C   1 
ATOM   582  O  O   . HIS   A 1 160 ? -23.75821 -9.59876  26.73756 1.000 13.84414 ? 160 HIS   A O   1 
ATOM   583  C  CB  . HIS   A 1 160 ? -24.14597 -6.88047  27.21886 1.000 10.96308 ? 160 HIS   A CB  1 
ATOM   584  C  CG  . HIS   A 1 160 ? -24.06324 -5.40116  27.43354 1.000 13.08110 ? 160 HIS   A CG  1 
ATOM   585  N  ND1 . HIS   A 1 160 ? -25.15361 -4.56694  27.31123 1.000 9.05021  ? 160 HIS   A ND1 1 
ATOM   586  C  CD2 . HIS   A 1 160 ? -23.01423 -4.60462  27.74773 1.000 11.01689 ? 160 HIS   A CD2 1 
ATOM   587  C  CE1 . HIS   A 1 160 ? -24.78165 -3.32144  27.54846 1.000 13.13843 ? 160 HIS   A CE1 1 
ATOM   588  N  NE2 . HIS   A 1 160 ? -23.48806 -3.31682  27.81540 1.000 12.20742 ? 160 HIS   A NE2 1 
ATOM   589  N  N   . ASN   A 1 161 ? -22.70158 -9.29073  24.77933 1.000 13.23056 ? 161 ASN   A N   1 
ATOM   590  C  CA  . ASN   A 1 161 ? -22.42490 -10.69610 24.52567 1.000 13.59753 ? 161 ASN   A CA  1 
ATOM   591  C  C   . ASN   A 1 161 ? -20.91541 -10.91163 24.41764 1.000 14.87856 ? 161 ASN   A C   1 
ATOM   592  O  O   . ASN   A 1 161 ? -20.11189 -10.03186 24.74094 1.000 9.81862  ? 161 ASN   A O   1 
ATOM   593  C  CB  . ASN   A 1 161 ? -23.15500 -11.16243 23.26319 1.000 12.93984 ? 161 ASN   A CB  1 
ATOM   594  C  CG  . ASN   A 1 161 ? -22.89597 -10.25866 22.07153 1.000 13.04655 ? 161 ASN   A CG  1 
ATOM   595  O  OD1 . ASN   A 1 161 ? -21.75217 -9.92727  21.76380 1.000 13.36088 ? 161 ASN   A OD1 1 
ATOM   596  N  ND2 . ASN   A 1 161 ? -23.96424 -9.84604  21.40050 1.000 13.02547 ? 161 ASN   A ND2 1 
ATOM   597  N  N   . ASN   A 1 162 ? -20.53986 -12.10086 23.94118 1.000 12.04225 ? 162 ASN   A N   1 
ATOM   598  C  CA  . ASN   A 1 162 ? -19.12909 -12.45858 23.84832 1.000 12.31967 ? 162 ASN   A CA  1 
ATOM   599  C  C   . ASN   A 1 162 ? -18.39357 -11.61336 22.81775 1.000 13.00699 ? 162 ASN   A C   1 
ATOM   600  O  O   . ASN   A 1 162 ? -17.17103 -11.45654 22.90724 1.000 12.53187 ? 162 ASN   A O   1 
ATOM   601  C  CB  . ASN   A 1 162 ? -18.99158 -13.94055 23.51032 1.000 12.37758 ? 162 ASN   A CB  1 
ATOM   602  C  CG  . ASN   A 1 162 ? -19.68725 -14.30337 22.21580 1.000 16.15343 ? 162 ASN   A CG  1 
ATOM   603  O  OD1 . ASN   A 1 162 ? -20.70787 -13.71226 21.86016 1.000 19.50533 ? 162 ASN   A OD1 1 
ATOM   604  N  ND2 . ASN   A 1 162 ? -19.14097 -15.28007 21.50354 1.000 16.56306 ? 162 ASN   A ND2 1 
ATOM   605  N  N   . ILE   A 1 163 ? -19.10719 -11.07526 21.82722 1.000 11.97667 ? 163 ILE   A N   1 
ATOM   606  C  CA  . ILE   A 1 163 ? -18.46221 -10.21142 20.84249 1.000 11.38448 ? 163 ILE   A CA  1 
ATOM   607  C  C   . ILE   A 1 163 ? -18.02263 -8.90515  21.49295 1.000 9.22732  ? 163 ILE   A C   1 
ATOM   608  O  O   . ILE   A 1 163 ? -16.90419 -8.42627  21.27027 1.000 10.60341 ? 163 ILE   A O   1 
ATOM   609  C  CB  . ILE   A 1 163 ? -19.39732 -9.95902  19.64715 1.000 13.59980 ? 163 ILE   A CB  1 
ATOM   610  C  CG1 . ILE   A 1 163 ? -19.92934 -11.27959 19.08879 1.000 12.21081 ? 163 ILE   A CG1 1 
ATOM   611  C  CG2 . ILE   A 1 163 ? -18.66999 -9.17883  18.56671 1.000 11.58615 ? 163 ILE   A CG2 1 
ATOM   612  C  CD1 . ILE   A 1 163 ? -20.87964 -11.10232 17.91856 1.000 12.01924 ? 163 ILE   A CD1 1 
ATOM   613  N  N   . HIS   A 1 164 ? -18.89940 -8.30804  22.30467 1.000 11.71164 ? 164 HIS   A N   1 
ATOM   614  C  CA  . HIS   A 1 164 ? -18.52474 -7.10862  23.04717 1.000 11.20369 ? 164 HIS   A CA  1 
ATOM   615  C  C   . HIS   A 1 164 ? -17.33925 -7.37657  23.96453 1.000 10.02126 ? 164 HIS   A C   1 
ATOM   616  O  O   . HIS   A 1 164 ? -16.41996 -6.55489  24.06066 1.000 9.04178  ? 164 HIS   A O   1 
ATOM   617  C  CB  . HIS   A 1 164 ? -19.71728 -6.59903  23.85386 1.000 9.55765  ? 164 HIS   A CB  1 
ATOM   618  C  CG  . HIS   A 1 164 ? -19.37171 -5.50499  24.81425 1.000 8.83840  ? 164 HIS   A CG  1 
ATOM   619  N  ND1 . HIS   A 1 164 ? -18.94581 -4.26046  24.40245 1.000 10.53440 ? 164 HIS   A ND1 1 
ATOM   620  C  CD2 . HIS   A 1 164 ? -19.38051 -5.47146  26.16790 1.000 10.17328 ? 164 HIS   A CD2 1 
ATOM   621  C  CE1 . HIS   A 1 164 ? -18.71325 -3.50508  25.46086 1.000 9.95342  ? 164 HIS   A CE1 1 
ATOM   622  N  NE2 . HIS   A 1 164 ? -18.96861 -4.21610  26.54454 1.000 9.42947  ? 164 HIS   A NE2 1 
ATOM   623  N  N   . ALA   A 1 165 ? -17.34249 -8.52499  24.64437 1.000 8.41654  ? 165 ALA   A N   1 
ATOM   624  C  CA  . ALA   A 1 165 ? -16.22713 -8.87728  25.51685 1.000 9.57313  ? 165 ALA   A CA  1 
ATOM   625  C  C   . ALA   A 1 165 ? -14.93077 -9.00247  24.72665 1.000 10.61801 ? 165 ALA   A C   1 
ATOM   626  O  O   . ALA   A 1 165 ? -13.88844 -8.47607  25.13297 1.000 12.10506 ? 165 ALA   A O   1 
ATOM   627  C  CB  . ALA   A 1 165 ? -16.53503 -10.17729 26.25702 1.000 10.18230 ? 165 ALA   A CB  1 
ATOM   628  N  N   . ALA   A 1 166 ? -14.97752 -9.70049  23.58943 1.000 12.15790 ? 166 ALA   A N   1 
ATOM   629  C  CA  . ALA   A 1 166 ? -13.79072 -9.82389  22.74932 1.000 11.53763 ? 166 ALA   A CA  1 
ATOM   630  C  C   . ALA   A 1 166 ? -13.33752 -8.46425  22.23448 1.000 12.37773 ? 166 ALA   A C   1 
ATOM   631  O  O   . ALA   A 1 166 ? -12.13378 -8.19172  22.15052 1.000 10.27899 ? 166 ALA   A O   1 
ATOM   632  C  CB  . ALA   A 1 166 ? -14.07058 -10.77202 21.58435 1.000 13.21179 ? 166 ALA   A CB  1 
ATOM   633  N  N   . ASP   A 1 167 ? -14.29194 -7.59792  21.88622 1.000 13.78070 ? 167 ASP   A N   1 
ATOM   634  C  CA  . ASP   A 1 167 ? -13.95363 -6.26256  21.40534 1.000 11.87994 ? 167 ASP   A CA  1 
ATOM   635  C  C   . ASP   A 1 167 ? -13.22869 -5.45650  22.47624 1.000 10.62097 ? 167 ASP   A C   1 
ATOM   636  O  O   . ASP   A 1 167 ? -12.23014 -4.78530  22.19019 1.000 10.98861 ? 167 ASP   A O   1 
ATOM   637  C  CB  . ASP   A 1 167 ? -15.22496 -5.54274  20.95344 1.000 12.01142 ? 167 ASP   A CB  1 
ATOM   638  C  CG  . ASP   A 1 167 ? -14.95967 -4.13481  20.46129 1.000 16.27084 ? 167 ASP   A CG  1 
ATOM   639  O  OD1 . ASP   A 1 167 ? -13.95614 -3.92944  19.74607 1.000 11.71037 ? 167 ASP   A OD1 1 
ATOM   640  O  OD2 . ASP   A 1 167 ? -15.76226 -3.23415  20.78893 1.000 12.07815 ? 167 ASP   A OD2 1 
ATOM   641  N  N   . VAL   A 1 168 ? -13.71127 -5.51887  23.71876 1.000 10.06280 ? 168 VAL   A N   1 
ATOM   642  C  CA  . VAL   A 1 168 ? -13.09897 -4.74690  24.79563 1.000 9.32759  ? 168 VAL   A CA  1 
ATOM   643  C  C   . VAL   A 1 168 ? -11.73198 -5.31760  25.15578 1.000 8.91988  ? 168 VAL   A C   1 
ATOM   644  O  O   . VAL   A 1 168 ? -10.79338 -4.56989  25.45751 1.000 9.58386  ? 168 VAL   A O   1 
ATOM   645  C  CB  . VAL   A 1 168 ? -14.04328 -4.69728  26.01041 1.000 9.52373  ? 168 VAL   A CB  1 
ATOM   646  C  CG1 . VAL   A 1 168 ? -13.34315 -4.09208  27.21551 1.000 9.47228  ? 168 VAL   A CG1 1 
ATOM   647  C  CG2 . VAL   A 1 168 ? -15.29090 -3.89857  25.66656 1.000 9.75706  ? 168 VAL   A CG2 1 
ATOM   648  N  N   . VAL   A 1 169 ? -11.59601 -6.64688  25.12763 1.000 8.71387  ? 169 VAL   A N   1 
ATOM   649  C  CA  . VAL   A 1 169 ? -10.29036 -7.27475  25.33032 1.000 9.49418  ? 169 VAL   A CA  1 
ATOM   650  C  C   . VAL   A 1 169 ? -9.28604  -6.74343  24.31964 1.000 11.91682 ? 169 VAL   A C   1 
ATOM   651  O  O   . VAL   A 1 169 ? -8.19152  -6.29059  24.67553 1.000 13.03917 ? 169 VAL   A O   1 
ATOM   652  C  CB  . VAL   A 1 169 ? -10.40785 -8.80548  25.23129 1.000 11.98068 ? 169 VAL   A CB  1 
ATOM   653  C  CG1 . VAL   A 1 169 ? -9.03012  -9.42768  25.06125 1.000 9.58407  ? 169 VAL   A CG1 1 
ATOM   654  C  CG2 . VAL   A 1 169 ? -11.08710 -9.35964  26.45121 1.000 11.46854 ? 169 VAL   A CG2 1 
ATOM   655  N  N   . GLN   A 1 170 ? -9.64949  -6.79596  23.03810 1.000 10.49227 ? 170 GLN   A N   1 
ATOM   656  C  CA  . GLN   A 1 170 ? -8.72043  -6.40212  21.98703 1.000 11.11931 ? 170 GLN   A CA  1 
ATOM   657  C  C   . GLN   A 1 170 ? -8.44656  -4.90426  22.02137 1.000 13.66060 ? 170 GLN   A C   1 
ATOM   658  O  O   . GLN   A 1 170 ? -7.31002  -4.47170  21.79600 1.000 11.00749 ? 170 GLN   A O   1 
ATOM   659  C  CB  . GLN   A 1 170 ? -9.27125  -6.82708  20.62705 1.000 12.73144 ? 170 GLN   A CB  1 
ATOM   660  C  CG  . GLN   A 1 170 ? -8.28925  -6.67359  19.48367 1.000 13.12856 ? 170 GLN   A CG  1 
ATOM   661  C  CD  . GLN   A 1 170 ? -8.48513  -5.38342  18.71407 1.000 15.23797 ? 170 GLN   A CD  1 
ATOM   662  O  OE1 . GLN   A 1 170 ? -9.57021  -4.80073  18.72065 1.000 13.16613 ? 170 GLN   A OE1 1 
ATOM   663  N  NE2 . GLN   A 1 170 ? -7.43385  -4.93179  18.04041 1.000 12.80642 ? 170 GLN   A NE2 1 
ATOM   664  N  N   . SER   A 1 171 ? -9.47222  -4.09739  22.30514 1.000 9.99429  ? 171 SER   A N   1 
ATOM   665  C  CA  . SER   A 1 171 ? -9.26911  -2.65511  22.39751 1.000 11.32917 ? 171 SER   A CA  1 
ATOM   666  C  C   . SER   A 1 171 ? -8.36502  -2.30229  23.57151 1.000 13.59410 ? 171 SER   A C   1 
ATOM   667  O  O   . SER   A 1 171 ? -7.50067  -1.42543  23.45661 1.000 13.75100 ? 171 SER   A O   1 
ATOM   668  C  CB  . SER   A 1 171 ? -10.61467 -1.94032  22.51741 1.000 12.66323 ? 171 SER   A CB  1 
ATOM   669  O  OG  . SER   A 1 171 ? -11.44432 -2.23423  21.40709 1.000 12.73666 ? 171 SER   A OG  1 
ATOM   670  N  N   . THR   A 1 172 ? -8.55155  -2.97348  24.71167 1.000 14.73399 ? 172 THR   A N   1 
ATOM   671  C  CA  . THR   A 1 172 ? -7.63506  -2.79437  25.83364 1.000 10.04692 ? 172 THR   A CA  1 
ATOM   672  C  C   . THR   A 1 172 ? -6.22244  -3.22225  25.45684 1.000 15.80179 ? 172 THR   A C   1 
ATOM   673  O  O   . THR   A 1 172 ? -5.24429  -2.56074  25.82628 1.000 12.56825 ? 172 THR   A O   1 
ATOM   674  C  CB  . THR   A 1 172 ? -8.13050  -3.58275  27.04846 1.000 11.20614 ? 172 THR   A CB  1 
ATOM   675  O  OG1 . THR   A 1 172 ? -9.28875  -2.94320  27.59786 1.000 14.43749 ? 172 THR   A OG1 1 
ATOM   676  C  CG2 . THR   A 1 172 ? -7.05003  -3.67305  28.11872 1.000 14.66173 ? 172 THR   A CG2 1 
ATOM   677  N  N   . HIS   A 1 173 ? -6.10028  -4.32240  24.70876 1.000 14.13910 ? 173 HIS   A N   1 
ATOM   678  C  CA  . HIS   A 1 173 ? -4.78918  -4.78940  24.26883 1.000 14.59586 ? 173 HIS   A CA  1 
ATOM   679  C  C   . HIS   A 1 173 ? -4.05989  -3.72389  23.46012 1.000 14.28715 ? 173 HIS   A C   1 
ATOM   680  O  O   . HIS   A 1 173 ? -2.85134  -3.52409  23.62986 1.000 17.26166 ? 173 HIS   A O   1 
ATOM   681  C  CB  . HIS   A 1 173 ? -4.94197  -6.06918  23.44821 1.000 15.92391 ? 173 HIS   A CB  1 
ATOM   682  C  CG  . HIS   A 1 173 ? -3.70343  -6.46196  22.70588 1.000 16.77990 ? 173 HIS   A CG  1 
ATOM   683  N  ND1 . HIS   A 1 173 ? -2.54466  -6.84778  23.34358 1.000 17.67060 ? 173 HIS   A ND1 1 
ATOM   684  C  CD2 . HIS   A 1 173 ? -3.44062  -6.52302  21.37907 1.000 18.73467 ? 173 HIS   A CD2 1 
ATOM   685  C  CE1 . HIS   A 1 173 ? -1.62193  -7.13307  22.44251 1.000 18.46288 ? 173 HIS   A CE1 1 
ATOM   686  N  NE2 . HIS   A 1 173 ? -2.14005  -6.94417  21.24235 1.000 17.89126 ? 173 HIS   A NE2 1 
ATOM   687  N  N   . VAL   A 1 174 ? -4.77709  -3.02926  22.57513 1.000 16.49809 ? 174 VAL   A N   1 
ATOM   688  C  CA  . VAL   A 1 174 ? -4.15135  -1.98189  21.77441 1.000 15.89041 ? 174 VAL   A CA  1 
ATOM   689  C  C   . VAL   A 1 174 ? -3.78215  -0.78835  22.64696 1.000 16.22733 ? 174 VAL   A C   1 
ATOM   690  O  O   . VAL   A 1 174 ? -2.69425  -0.21543  22.50944 1.000 14.33158 ? 174 VAL   A O   1 
ATOM   691  C  CB  . VAL   A 1 174 ? -5.07657  -1.57410  20.61339 1.000 15.71059 ? 174 VAL   A CB  1 
ATOM   692  C  CG1 . VAL   A 1 174 ? -4.49496  -0.38825  19.85889 1.000 17.60685 ? 174 VAL   A CG1 1 
ATOM   693  C  CG2 . VAL   A 1 174 ? -5.29525  -2.75115  19.67378 1.000 16.09208 ? 174 VAL   A CG2 1 
ATOM   694  N  N   . LEU   A 1 175 ? -4.67395  -0.39890  23.56277 1.000 13.46545 ? 175 LEU   A N   1 
ATOM   695  C  CA  . LEU   A 1 175 ? -4.39577  0.74554   24.42495 1.000 17.34891 ? 175 LEU   A CA  1 
ATOM   696  C  C   . LEU   A 1 175 ? -3.20158  0.48844   25.33569 1.000 19.39007 ? 175 LEU   A C   1 
ATOM   697  O  O   . LEU   A 1 175 ? -2.46601  1.42320   25.67125 1.000 23.06402 ? 175 LEU   A O   1 
ATOM   698  C  CB  . LEU   A 1 175 ? -5.63374  1.09263   25.25307 1.000 15.62377 ? 175 LEU   A CB  1 
ATOM   699  C  CG  . LEU   A 1 175 ? -6.84083  1.62540   24.47567 1.000 13.54267 ? 175 LEU   A CG  1 
ATOM   700  C  CD1 . LEU   A 1 175 ? -7.98871  1.96723   25.41491 1.000 11.86029 ? 175 LEU   A CD1 1 
ATOM   701  C  CD2 . LEU   A 1 175 ? -6.45220  2.83495   23.63621 1.000 15.71051 ? 175 LEU   A CD2 1 
ATOM   702  N  N   . LEU   A 1 176 ? -2.98966  -0.76601  25.74224 1.000 17.42008 ? 176 LEU   A N   1 
ATOM   703  C  CA  . LEU   A 1 176 ? -1.83242  -1.08990  26.57085 1.000 19.55514 ? 176 LEU   A CA  1 
ATOM   704  C  C   . LEU   A 1 176 ? -0.52533  -0.90732  25.81200 1.000 21.60527 ? 176 LEU   A C   1 
ATOM   705  O  O   . LEU   A 1 176 ? 0.51849   -0.66269  26.42804 1.000 21.89848 ? 176 LEU   A O   1 
ATOM   706  C  CB  . LEU   A 1 176 ? -1.93438  -2.52402  27.08920 1.000 15.51228 ? 176 LEU   A CB  1 
ATOM   707  C  CG  . LEU   A 1 176 ? -2.79756  -2.78664  28.32221 1.000 22.32948 ? 176 LEU   A CG  1 
ATOM   708  C  CD1 . LEU   A 1 176 ? -3.01297  -4.27996  28.50743 1.000 14.91579 ? 176 LEU   A CD1 1 
ATOM   709  C  CD2 . LEU   A 1 176 ? -2.14190  -2.18677  29.55173 1.000 18.50044 ? 176 LEU   A CD2 1 
ATOM   710  N  N   . SER   A 1 177 ? -0.55802  -1.02517  24.48713 1.000 21.62891 ? 177 SER   A N   1 
ATOM   711  C  CA  . SER   A 1 177 ? 0.64191   -0.94644  23.66551 1.000 21.18139 ? 177 SER   A CA  1 
ATOM   712  C  C   . SER   A 1 177 ? 0.99724   0.47578   23.26114 1.000 25.70449 ? 177 SER   A C   1 
ATOM   713  O  O   . SER   A 1 177 ? 1.94543   0.66551   22.49206 1.000 25.02014 ? 177 SER   A O   1 
ATOM   714  C  CB  . SER   A 1 177 ? 0.47215   -1.80001  22.40491 1.000 21.16024 ? 177 SER   A CB  1 
ATOM   715  O  OG  . SER   A 1 177 ? 0.10528   -3.12761  22.73196 1.000 24.69493 ? 177 SER   A OG  1 
ATOM   716  N  N   . THR   A 1 178 ? 0.26667   1.46909   23.75024 1.000 22.97734 ? 178 THR   A N   1 
ATOM   717  C  CA  . THR   A 1 178 ? 0.49293   2.83359   23.30743 1.000 26.42056 ? 178 THR   A CA  1 
ATOM   718  C  C   . THR   A 1 178 ? 1.87772   3.30613   23.75351 1.000 26.03743 ? 178 THR   A C   1 
ATOM   719  O  O   . THR   A 1 178 ? 2.33760   2.94782   24.84358 1.000 20.94048 ? 178 THR   A O   1 
ATOM   720  C  CB  . THR   A 1 178 ? -0.60620  3.75409   23.84445 1.000 25.11935 ? 178 THR   A CB  1 
ATOM   721  O  OG1 . THR   A 1 178 ? -0.58523  4.99083   23.13470 1.000 27.73525 ? 178 THR   A OG1 1 
ATOM   722  C  CG2 . THR   A 1 178 ? -0.42253  4.03209   25.31514 1.000 23.79957 ? 178 THR   A CG2 1 
ATOM   723  N  N   . PRO   A 1 179 ? 2.58632   4.06706   22.91198 1.000 29.12210 ? 179 PRO   A N   1 
ATOM   724  C  CA  . PRO   A 1 179 ? 3.97940   4.41865   23.24386 1.000 29.51420 ? 179 PRO   A CA  1 
ATOM   725  C  C   . PRO   A 1 179 ? 4.13704   5.14936   24.56561 1.000 26.87602 ? 179 PRO   A C   1 
ATOM   726  O  O   . PRO   A 1 179 ? 5.14239   4.94896   25.25913 1.000 30.37872 ? 179 PRO   A O   1 
ATOM   727  C  CB  . PRO   A 1 179 ? 4.40270   5.29270   22.05659 1.000 24.83605 ? 179 PRO   A CB  1 
ATOM   728  C  CG  . PRO   A 1 179 ? 3.56853   4.79790   20.92471 1.000 29.11659 ? 179 PRO   A CG  1 
ATOM   729  C  CD  . PRO   A 1 179 ? 2.23759   4.43098   21.52763 1.000 27.40118 ? 179 PRO   A CD  1 
ATOM   730  N  N   . ALA   A 1 180 ? 3.16908   5.98716   24.94262 1.000 26.19846 ? 180 ALA   A N   1 
ATOM   731  C  CA  . ALA   A 1 180 ? 3.26922   6.73513   26.19024 1.000 24.50214 ? 180 ALA   A CA  1 
ATOM   732  C  C   . ALA   A 1 180 ? 3.18635   5.84739   27.42418 1.000 26.45517 ? 180 ALA   A C   1 
ATOM   733  O  O   . ALA   A 1 180 ? 3.39418   6.34458   28.53599 1.000 23.55258 ? 180 ALA   A O   1 
ATOM   734  C  CB  . ALA   A 1 180 ? 2.17719   7.80420   26.25349 1.000 24.64655 ? 180 ALA   A CB  1 
ATOM   735  N  N   . LEU   A 1 181 ? 2.89070   4.55804   27.26177 1.000 24.14386 ? 181 LEU   A N   1 
ATOM   736  C  CA  . LEU   A 1 181 ? 2.81989   3.63019   28.38280 1.000 26.14550 ? 181 LEU   A CA  1 
ATOM   737  C  C   . LEU   A 1 181 ? 3.83132   2.49626   28.27591 1.000 26.40774 ? 181 LEU   A C   1 
ATOM   738  O  O   . LEU   A 1 181 ? 3.72509   1.51901   29.02658 1.000 25.94085 ? 181 LEU   A O   1 
ATOM   739  C  CB  . LEU   A 1 181 ? 1.40713   3.05204   28.50745 1.000 28.51410 ? 181 LEU   A CB  1 
ATOM   740  C  CG  . LEU   A 1 181 ? 0.28330   4.05636   28.76663 1.000 26.16802 ? 181 LEU   A CG  1 
ATOM   741  C  CD1 . LEU   A 1 181 ? -1.06636  3.36003   28.76531 1.000 16.69339 ? 181 LEU   A CD1 1 
ATOM   742  C  CD2 . LEU   A 1 181 ? 0.50777   4.79098   30.07422 1.000 21.99638 ? 181 LEU   A CD2 1 
ATOM   743  N  N   . GLU   A 1 182 ? 4.80668   2.59525   27.37310 1.000 23.25563 ? 182 GLU   A N   1 
ATOM   744  C  CA  . GLU   A 1 182 ? 5.74332   1.49675   27.17421 1.000 28.14169 ? 182 GLU   A CA  1 
ATOM   745  C  C   . GLU   A 1 182 ? 6.52674   1.21989   28.44990 1.000 29.20397 ? 182 GLU   A C   1 
ATOM   746  O  O   . GLU   A 1 182 ? 7.11505   2.12883   29.04338 1.000 24.84546 ? 182 GLU   A O   1 
ATOM   747  C  CB  . GLU   A 1 182 ? 6.70373   1.80181   26.02493 1.000 31.57065 ? 182 GLU   A CB  1 
ATOM   748  C  CG  . GLU   A 1 182 ? 7.75611   0.71690   25.83750 1.000 38.10822 ? 182 GLU   A CG  1 
ATOM   749  C  CD  . GLU   A 1 182 ? 8.56069   0.86969   24.56168 1.000 38.66775 ? 182 GLU   A CD  1 
ATOM   750  O  OE1 . GLU   A 1 182 ? 9.50714   0.07893   24.36716 1.000 45.34237 ? 182 GLU   A OE1 1 
ATOM   751  O  OE2 . GLU   A 1 182 ? 8.24949   1.76977   23.75392 1.000 35.97031 ? 182 GLU   A OE2 1 
ATOM   752  N  N   . ALA   A 1 183 ? 6.51203   -0.04597  28.87337 1.000 27.11106 ? 183 ALA   A N   1 
ATOM   753  C  CA  . ALA   A 1 183 ? 7.23223   -0.50981  30.05979 1.000 34.03818 ? 183 ALA   A CA  1 
ATOM   754  C  C   . ALA   A 1 183 ? 6.76367   0.19110   31.33348 1.000 27.81290 ? 183 ALA   A C   1 
ATOM   755  O  O   . ALA   A 1 183 ? 7.50481   0.26863   32.31570 1.000 38.35134 ? 183 ALA   A O   1 
ATOM   756  C  CB  . ALA   A 1 183 ? 8.74627   -0.35367  29.88877 1.000 35.95897 ? 183 ALA   A CB  1 
ATOM   757  N  N   . VAL   A 1 184 ? 5.53349   0.70853   31.33403 1.000 28.39161 ? 184 VAL   A N   1 
ATOM   758  C  CA  . VAL   A 1 184 ? 4.97357   1.28779   32.55277 1.000 25.84745 ? 184 VAL   A CA  1 
ATOM   759  C  C   . VAL   A 1 184 ? 4.43233   0.19958   33.46328 1.000 24.75314 ? 184 VAL   A C   1 
ATOM   760  O  O   . VAL   A 1 184 ? 4.72294   0.16740   34.66445 1.000 26.89180 ? 184 VAL   A O   1 
ATOM   761  C  CB  . VAL   A 1 184 ? 3.87120   2.30874   32.22040 1.000 28.31128 ? 184 VAL   A CB  1 
ATOM   762  C  CG1 . VAL   A 1 184 ? 3.08113   2.64641   33.47179 1.000 23.67440 ? 184 VAL   A CG1 1 
ATOM   763  C  CG2 . VAL   A 1 184 ? 4.46335   3.54720   31.67433 1.000 27.80369 ? 184 VAL   A CG2 1 
ATOM   764  N  N   . PHE   A 1 185 ? 3.62747   -0.69607  32.90751 1.000 24.00492 ? 185 PHE   A N   1 
ATOM   765  C  CA  . PHE   A 1 185 ? 2.87818   -1.66173  33.69126 1.000 22.06594 ? 185 PHE   A CA  1 
ATOM   766  C  C   . PHE   A 1 185 ? 3.59833   -3.00093  33.72619 1.000 22.30297 ? 185 PHE   A C   1 
ATOM   767  O  O   . PHE   A 1 185 ? 4.18052   -3.43561  32.72768 1.000 18.90589 ? 185 PHE   A O   1 
ATOM   768  C  CB  . PHE   A 1 185 ? 1.46740   -1.83421  33.12627 1.000 22.33962 ? 185 PHE   A CB  1 
ATOM   769  C  CG  . PHE   A 1 185 ? 0.60971   -0.60957  33.26910 1.000 20.80333 ? 185 PHE   A CG  1 
ATOM   770  C  CD1 . PHE   A 1 185 ? 0.19920   -0.18289  34.52112 1.000 23.28918 ? 185 PHE   A CD1 1 
ATOM   771  C  CD2 . PHE   A 1 185 ? 0.21761   0.11698   32.15586 1.000 16.86230 ? 185 PHE   A CD2 1 
ATOM   772  C  CE1 . PHE   A 1 185 ? -0.58714  0.94398   34.66294 1.000 19.64011 ? 185 PHE   A CE1 1 
ATOM   773  C  CE2 . PHE   A 1 185 ? -0.57136  1.24596   32.29070 1.000 20.54172 ? 185 PHE   A CE2 1 
ATOM   774  C  CZ  . PHE   A 1 185 ? -0.97336  1.65983   33.54647 1.000 17.65419 ? 185 PHE   A CZ  1 
ATOM   775  N  N   . THR   A 1 186 ? 3.56039   -3.64423  34.88896 1.000 22.27315 ? 186 THR   A N   1 
ATOM   776  C  CA  . THR   A 1 186 ? 4.11150   -4.97985  35.02859 1.000 23.18983 ? 186 THR   A CA  1 
ATOM   777  C  C   . THR   A 1 186 ? 3.29441   -5.97647  34.21234 1.000 23.26080 ? 186 THR   A C   1 
ATOM   778  O  O   . THR   A 1 186 ? 2.17215   -5.69707  33.77919 1.000 21.89385 ? 186 THR   A O   1 
ATOM   779  C  CB  . THR   A 1 186 ? 4.12690   -5.40603  36.49704 1.000 23.91740 ? 186 THR   A CB  1 
ATOM   780  O  OG1 . THR   A 1 186 ? 2.78176   -5.49048  36.98459 1.000 22.27722 ? 186 THR   A OG1 1 
ATOM   781  C  CG2 . THR   A 1 186 ? 4.89758   -4.39984  37.33671 1.000 21.93218 ? 186 THR   A CG2 1 
ATOM   782  N  N   . ASP   A 1 187 ? 3.87789   -7.15911  34.00252 1.000 18.98266 ? 187 ASP   A N   1 
ATOM   783  C  CA  . ASP   A 1 187 ? 3.14411   -8.22790  33.33427 1.000 21.62700 ? 187 ASP   A CA  1 
ATOM   784  C  C   . ASP   A 1 187 ? 1.90104   -8.62245  34.11963 1.000 21.60595 ? 187 ASP   A C   1 
ATOM   785  O  O   . ASP   A 1 187 ? 0.89742   -9.03563  33.52766 1.000 19.13548 ? 187 ASP   A O   1 
ATOM   786  C  CB  . ASP   A 1 187 ? 4.05069   -9.44105  33.12756 1.000 26.04093 ? 187 ASP   A CB  1 
ATOM   787  C  CG  . ASP   A 1 187 ? 5.21288   -9.14821  32.19940 1.000 27.26650 ? 187 ASP   A CG  1 
ATOM   788  O  OD1 . ASP   A 1 187 ? 5.04805   -8.31865  31.28005 1.000 28.21768 ? 187 ASP   A OD1 1 
ATOM   789  O  OD2 . ASP   A 1 187 ? 6.29155   -9.74713  32.39052 1.000 29.27435 ? 187 ASP   A OD2 1 
ATOM   790  N  N   . LEU   A 1 188 ? 1.94436   -8.49473  35.44793 1.000 18.26450 ? 188 LEU   A N   1 
ATOM   791  C  CA  . LEU   A 1 188 ? 0.77538   -8.81574  36.25877 1.000 18.14371 ? 188 LEU   A CA  1 
ATOM   792  C  C   . LEU   A 1 188 ? -0.33363  -7.79050  36.05679 1.000 18.48017 ? 188 LEU   A C   1 
ATOM   793  O  O   . LEU   A 1 188 ? -1.51344  -8.15215  35.97746 1.000 17.16728 ? 188 LEU   A O   1 
ATOM   794  C  CB  . LEU   A 1 188 ? 1.16707   -8.90161  37.73307 1.000 16.43209 ? 188 LEU   A CB  1 
ATOM   795  C  CG  . LEU   A 1 188 ? 0.10774   -9.50421  38.65555 1.000 16.51420 ? 188 LEU   A CG  1 
ATOM   796  C  CD1 . LEU   A 1 188 ? -0.18622  -10.93961 38.24867 1.000 20.92143 ? 188 LEU   A CD1 1 
ATOM   797  C  CD2 . LEU   A 1 188 ? 0.54978   -9.43253  40.10854 1.000 17.04127 ? 188 LEU   A CD2 1 
ATOM   798  N  N   . GLU   A 1 189 ? 0.02459   -6.50648  35.97500 1.000 17.48818 ? 189 GLU   A N   1 
ATOM   799  C  CA  . GLU   A 1 189 ? -0.97163  -5.47669  35.69709 1.000 13.29780 ? 189 GLU   A CA  1 
ATOM   800  C  C   . GLU   A 1 189 ? -1.53016  -5.61935  34.28720 1.000 17.06345 ? 189 GLU   A C   1 
ATOM   801  O  O   . GLU   A 1 189 ? -2.73262  -5.42993  34.06675 1.000 15.33725 ? 189 GLU   A O   1 
ATOM   802  C  CB  . GLU   A 1 189 ? -0.36035  -4.09058  35.89719 1.000 15.96075 ? 189 GLU   A CB  1 
ATOM   803  C  CG  . GLU   A 1 189 ? 0.05921   -3.79965  37.32901 1.000 16.94695 ? 189 GLU   A CG  1 
ATOM   804  C  CD  . GLU   A 1 189 ? 0.96978   -2.59308  37.43477 1.000 21.73308 ? 189 GLU   A CD  1 
ATOM   805  O  OE1 . GLU   A 1 189 ? 1.83414   -2.42312  36.55189 1.000 19.82873 ? 189 GLU   A OE1 1 
ATOM   806  O  OE2 . GLU   A 1 189 ? 0.82153   -1.81353  38.39833 1.000 24.38646 ? 189 GLU   A OE2 1 
ATOM   807  N  N   . ILE   A 1 190 ? -0.66917  -5.94402  33.31989 1.000 14.15326 ? 190 ILE   A N   1 
ATOM   808  C  CA  . ILE   A 1 190 ? -1.13597  -6.23196  31.96674 1.000 19.98833 ? 190 ILE   A CA  1 
ATOM   809  C  C   . ILE   A 1 190 ? -2.08916  -7.41900  31.97922 1.000 20.43302 ? 190 ILE   A C   1 
ATOM   810  O  O   . ILE   A 1 190 ? -3.13269  -7.40688  31.31406 1.000 17.35617 ? 190 ILE   A O   1 
ATOM   811  C  CB  . ILE   A 1 190 ? 0.06493   -6.47631  31.03361 1.000 17.36931 ? 190 ILE   A CB  1 
ATOM   812  C  CG1 . ILE   A 1 190 ? 0.83355   -5.17388  30.80349 1.000 20.91131 ? 190 ILE   A CG1 1 
ATOM   813  C  CG2 . ILE   A 1 190 ? -0.38833  -7.08626  29.71367 1.000 13.81399 ? 190 ILE   A CG2 1 
ATOM   814  C  CD1 . ILE   A 1 190 ? 2.18801   -5.37132  30.15766 1.000 18.10338 ? 190 ILE   A CD1 1 
ATOM   815  N  N   . LEU   A 1 191 ? -1.74866  -8.45914  32.74394 1.000 15.69110 ? 191 LEU   A N   1 
ATOM   816  C  CA  . LEU   A 1 191 ? -2.63104  -9.61386  32.86828 1.000 17.26869 ? 191 LEU   A CA  1 
ATOM   817  C  C   . LEU   A 1 191 ? -3.95301  -9.22857  33.52035 1.000 14.55220 ? 191 LEU   A C   1 
ATOM   818  O  O   . LEU   A 1 191 ? -5.02069  -9.67814  33.08829 1.000 15.00368 ? 191 LEU   A O   1 
ATOM   819  C  CB  . LEU   A 1 191 ? -1.93284  -10.71449 33.66827 1.000 16.69939 ? 191 LEU   A CB  1 
ATOM   820  C  CG  . LEU   A 1 191 ? -2.68071  -12.02649 33.91109 1.000 15.25048 ? 191 LEU   A CG  1 
ATOM   821  C  CD1 . LEU   A 1 191 ? -3.02256  -12.71226 32.59807 1.000 12.71865 ? 191 LEU   A CD1 1 
ATOM   822  C  CD2 . LEU   A 1 191 ? -1.85410  -12.94570 34.79859 1.000 16.21668 ? 191 LEU   A CD2 1 
ATOM   823  N  N   . ALA   A 1 192 ? -3.90150  -8.38751  34.55610 1.000 16.05251 ? 192 ALA   A N   1 
ATOM   824  C  CA  . ALA   A 1 192 ? -5.12132  -7.97159  35.24149 1.000 16.04555 ? 192 ALA   A CA  1 
ATOM   825  C  C   . ALA   A 1 192 ? -6.05124  -7.21416  34.30181 1.000 13.93898 ? 192 ALA   A C   1 
ATOM   826  O  O   . ALA   A 1 192 ? -7.25869  -7.47541  34.26073 1.000 16.64413 ? 192 ALA   A O   1 
ATOM   827  C  CB  . ALA   A 1 192 ? -4.77182  -7.11389  36.45814 1.000 14.70449 ? 192 ALA   A CB  1 
ATOM   828  N  N   . ALA   A 1 193 ? -5.50096  -6.27367  33.53036 1.000 12.62656 ? 193 ALA   A N   1 
ATOM   829  C  CA  . ALA   A 1 193 ? -6.33193  -5.44140  32.66583 1.000 12.56110 ? 193 ALA   A CA  1 
ATOM   830  C  C   . ALA   A 1 193 ? -6.99079  -6.26113  31.56323 1.000 13.80434 ? 193 ALA   A C   1 
ATOM   831  O  O   . ALA   A 1 193 ? -8.17533  -6.06899  31.26418 1.000 12.59691 ? 193 ALA   A O   1 
ATOM   832  C  CB  . ALA   A 1 193 ? -5.49634  -4.31047  32.06795 1.000 11.75458 ? 193 ALA   A CB  1 
ATOM   833  N  N   . ILE   A 1 194 ? -6.24244  -7.17626  30.94506 1.000 10.59018 ? 194 ILE   A N   1 
ATOM   834  C  CA  . ILE   A 1 194 ? -6.81478  -8.00459  29.88846 1.000 11.04299 ? 194 ILE   A CA  1 
ATOM   835  C  C   . ILE   A 1 194 ? -7.84331  -8.97090  30.46270 1.000 12.95665 ? 194 ILE   A C   1 
ATOM   836  O  O   . ILE   A 1 194 ? -8.92437  -9.15883  29.89094 1.000 11.06540 ? 194 ILE   A O   1 
ATOM   837  C  CB  . ILE   A 1 194 ? -5.69842  -8.74131  29.12681 1.000 13.20008 ? 194 ILE   A CB  1 
ATOM   838  C  CG1 . ILE   A 1 194 ? -4.81919  -7.73440  28.38348 1.000 14.25834 ? 194 ILE   A CG1 1 
ATOM   839  C  CG2 . ILE   A 1 194 ? -6.28511  -9.75860  28.15970 1.000 11.80369 ? 194 ILE   A CG2 1 
ATOM   840  C  CD1 . ILE   A 1 194 ? -3.55432  -8.32826  27.81234 1.000 16.76860 ? 194 ILE   A CD1 1 
ATOM   841  N  N   . PHE   A 1 195 ? -7.52958  -9.59430  31.60114 1.000 13.55185 ? 195 PHE   A N   1 
ATOM   842  C  CA  . PHE   A 1 195 ? -8.48000  -10.50404 32.23395 1.000 10.87512 ? 195 PHE   A CA  1 
ATOM   843  C  C   . PHE   A 1 195 ? -9.74456  -9.76737  32.65417 1.000 13.59824 ? 195 PHE   A C   1 
ATOM   844  O  O   . PHE   A 1 195 ? -10.86131 -10.24945 32.42980 1.000 11.96836 ? 195 PHE   A O   1 
ATOM   845  C  CB  . PHE   A 1 195 ? -7.83351  -11.18979 33.43754 1.000 14.47440 ? 195 PHE   A CB  1 
ATOM   846  C  CG  . PHE   A 1 195 ? -8.75198  -12.13171 34.16396 1.000 16.11819 ? 195 PHE   A CG  1 
ATOM   847  C  CD1 . PHE   A 1 195 ? -9.00587  -13.39658 33.65961 1.000 15.40814 ? 195 PHE   A CD1 1 
ATOM   848  C  CD2 . PHE   A 1 195 ? -9.35807  -11.75541 35.35259 1.000 13.89197 ? 195 PHE   A CD2 1 
ATOM   849  C  CE1 . PHE   A 1 195 ? -9.84835  -14.26926 34.32363 1.000 12.25220 ? 195 PHE   A CE1 1 
ATOM   850  C  CE2 . PHE   A 1 195 ? -10.20249 -12.62338 36.02258 1.000 11.68078 ? 195 PHE   A CE2 1 
ATOM   851  C  CZ  . PHE   A 1 195 ? -10.44696 -13.88246 35.50665 1.000 15.13689 ? 195 PHE   A CZ  1 
ATOM   852  N  N   . ALA   A 1 196 ? -9.58558  -8.59485  33.27400 1.000 13.09244 ? 196 ALA   A N   1 
ATOM   853  C  CA  . ALA   A 1 196 ? -10.74193 -7.78703  33.64515 1.000 12.43634 ? 196 ALA   A CA  1 
ATOM   854  C  C   . ALA   A 1 196 ? -11.60905 -7.49220  32.42957 1.000 10.27997 ? 196 ALA   A C   1 
ATOM   855  O  O   . ALA   A 1 196 ? -12.83810 -7.59928  32.48763 1.000 10.15876 ? 196 ALA   A O   1 
ATOM   856  C  CB  . ALA   A 1 196 ? -10.28718 -6.48705  34.31015 1.000 9.06264  ? 196 ALA   A CB  1 
ATOM   857  N  N   . SER   A 1 197 ? -10.97619 -7.13556  31.30874 1.000 6.90499  ? 197 SER   A N   1 
ATOM   858  C  CA  . SER   A 1 197 ? -11.72415 -6.87050  30.08375 1.000 12.59849 ? 197 SER   A CA  1 
ATOM   859  C  C   . SER   A 1 197 ? -12.51966 -8.09312  29.64206 1.000 12.30416 ? 197 SER   A C   1 
ATOM   860  O  O   . SER   A 1 197 ? -13.64597 -7.96410  29.14766 1.000 12.61842 ? 197 SER   A O   1 
ATOM   861  C  CB  . SER   A 1 197 ? -10.77091 -6.42726  28.97281 1.000 9.17213  ? 197 SER   A CB  1 
ATOM   862  O  OG  . SER   A 1 197 ? -10.14792 -5.19506  29.28691 1.000 13.79578 ? 197 SER   A OG  1 
ATOM   863  N  N   . ALA   A 1 198 ? -11.95513 -9.28997  29.82384 1.000 10.31238 ? 198 ALA   A N   1 
ATOM   864  C  CA  . ALA   A 1 198 ? -12.60763 -10.50055 29.33329 1.000 12.36721 ? 198 ALA   A CA  1 
ATOM   865  C  C   . ALA   A 1 198 ? -13.86047 -10.83116 30.13321 1.000 11.65549 ? 198 ALA   A C   1 
ATOM   866  O  O   . ALA   A 1 198 ? -14.87134 -11.25781 29.56306 1.000 11.22938 ? 198 ALA   A O   1 
ATOM   867  C  CB  . ALA   A 1 198 ? -11.62724 -11.67186 29.36208 1.000 10.12455 ? 198 ALA   A CB  1 
ATOM   868  N  N   . ILE   A 1 199 ? -13.81741 -10.64115 31.45599 1.000 11.49396 ? 199 ILE   A N   1 
ATOM   869  C  CA  . ILE   A 1 199 ? -14.94077 -11.00626 32.31204 1.000 8.97235  ? 199 ILE   A CA  1 
ATOM   870  C  C   . ILE   A 1 199 ? -15.87585 -9.84066  32.59549 1.000 12.33011 ? 199 ILE   A C   1 
ATOM   871  O  O   . ILE   A 1 199 ? -16.90043 -10.03447 33.26495 1.000 11.43686 ? 199 ILE   A O   1 
ATOM   872  C  CB  . ILE   A 1 199 ? -14.44850 -11.56790 33.66150 1.000 13.20084 ? 199 ILE   A CB  1 
ATOM   873  C  CG1 . ILE   A 1 199 ? -13.77770 -10.45910 34.47703 1.000 9.76369  ? 199 ILE   A CG1 1 
ATOM   874  C  CG2 . ILE   A 1 199 ? -13.48848 -12.72553 33.44176 1.000 11.80209 ? 199 ILE   A CG2 1 
ATOM   875  C  CD1 . ILE   A 1 199 ? -13.55595 -10.81625 35.93072 1.000 7.98334  ? 199 ILE   A CD1 1 
ATOM   876  N  N   . HIS   A 1 200 ? -15.56988 -8.64054  32.09339 1.000 8.76738  ? 200 HIS   A N   1 
ATOM   877  C  CA  . HIS   A 1 200 ? -16.17060 -7.42541  32.63752 1.000 11.75616 ? 200 HIS   A CA  1 
ATOM   878  C  C   . HIS   A 1 200 ? -17.68024 -7.34970  32.43996 1.000 9.55900  ? 200 HIS   A C   1 
ATOM   879  O  O   . HIS   A 1 200 ? -18.33794 -6.58294  33.14929 1.000 10.64851 ? 200 HIS   A O   1 
ATOM   880  C  CB  . HIS   A 1 200 ? -15.50793 -6.18622  32.02892 1.000 7.16837  ? 200 HIS   A CB  1 
ATOM   881  C  CG  . HIS   A 1 200 ? -16.17548 -5.68063  30.78861 1.000 10.85913 ? 200 HIS   A CG  1 
ATOM   882  N  ND1 . HIS   A 1 200 ? -15.87548 -6.15951  29.53119 1.000 9.99130  ? 200 HIS   A ND1 1 
ATOM   883  C  CD2 . HIS   A 1 200 ? -17.11631 -4.72282  30.61222 1.000 11.82223 ? 200 HIS   A CD2 1 
ATOM   884  C  CE1 . HIS   A 1 200 ? -16.61014 -5.52583  28.63446 1.000 10.38078 ? 200 HIS   A CE1 1 
ATOM   885  N  NE2 . HIS   A 1 200 ? -17.37122 -4.64889  29.26443 1.000 8.84277  ? 200 HIS   A NE2 1 
ATOM   886  N  N   . ASP   A 1 201 ? -18.24873 -8.11553  31.50410 1.000 11.05709 ? 201 ASP   A N   1 
ATOM   887  C  CA  . ASP   A 1 201 ? -19.69141 -8.09961  31.28066 1.000 10.06433 ? 201 ASP   A CA  1 
ATOM   888  C  C   . ASP   A 1 201 ? -20.29456 -9.49940  31.28803 1.000 13.03563 ? 201 ASP   A C   1 
ATOM   889  O  O   . ASP   A 1 201 ? -21.38953 -9.69320  30.75154 1.000 14.93890 ? 201 ASP   A O   1 
ATOM   890  C  CB  . ASP   A 1 201 ? -20.03597 -7.40400  29.96042 1.000 9.89224  ? 201 ASP   A CB  1 
ATOM   891  C  CG  . ASP   A 1 201 ? -20.26852 -5.91593  30.12428 1.000 10.92020 ? 201 ASP   A CG  1 
ATOM   892  O  OD1 . ASP   A 1 201 ? -20.60067 -5.48131  31.24689 1.000 6.77667  ? 201 ASP   A OD1 1 
ATOM   893  O  OD2 . ASP   A 1 201 ? -20.13142 -5.18346  29.12250 1.000 9.53986  ? 201 ASP   A OD2 1 
ATOM   894  N  N   . VAL   A 1 202 ? -19.61228 -10.47834 31.88359 1.000 11.08822 ? 202 VAL   A N   1 
ATOM   895  C  CA  . VAL   A 1 202 ? -20.04464 -11.86501 31.76037 1.000 13.13670 ? 202 VAL   A CA  1 
ATOM   896  C  C   . VAL   A 1 202 ? -21.39337 -12.05776 32.44429 1.000 12.65332 ? 202 VAL   A C   1 
ATOM   897  O  O   . VAL   A 1 202 ? -21.68565 -11.44246 33.48007 1.000 12.97209 ? 202 VAL   A O   1 
ATOM   898  C  CB  . VAL   A 1 202 ? -18.97375 -12.81474 32.32660 1.000 11.42778 ? 202 VAL   A CB  1 
ATOM   899  C  CG1 . VAL   A 1 202 ? -18.82467 -12.63696 33.82805 1.000 14.31688 ? 202 VAL   A CG1 1 
ATOM   900  C  CG2 . VAL   A 1 202 ? -19.29915 -14.26059 31.97327 1.000 11.52263 ? 202 VAL   A CG2 1 
ATOM   901  N  N   . ASP   A 1 203 ? -22.23532 -12.90014 31.83944 1.000 12.70699 ? 203 ASP   A N   1 
ATOM   902  C  CA  . ASP   A 1 203 ? -23.58920 -13.18708 32.31992 1.000 13.70759 ? 203 ASP   A CA  1 
ATOM   903  C  C   . ASP   A 1 203 ? -24.45192 -11.92826 32.37864 1.000 14.81076 ? 203 ASP   A C   1 
ATOM   904  O  O   . ASP   A 1 203 ? -25.35040 -11.81457 33.21645 1.000 14.24201 ? 203 ASP   A O   1 
ATOM   905  C  CB  . ASP   A 1 203 ? -23.56474 -13.89229 33.67992 1.000 14.85766 ? 203 ASP   A CB  1 
ATOM   906  C  CG  . ASP   A 1 203 ? -24.83818 -14.67366 33.95333 1.000 17.63194 ? 203 ASP   A CG  1 
ATOM   907  O  OD1 . ASP   A 1 203 ? -25.39400 -15.25701 32.99846 1.000 20.84871 ? 203 ASP   A OD1 1 
ATOM   908  O  OD2 . ASP   A 1 203 ? -25.28248 -14.70415 35.11977 1.000 13.32453 ? 203 ASP   A OD2 1 
ATOM   909  N  N   . HIS   A 1 204 ? -24.18735 -10.98146 31.48664 1.000 11.78955 ? 204 HIS   A N   1 
ATOM   910  C  CA  . HIS   A 1 204 ? -25.02072 -9.78945  31.38570 1.000 13.39573 ? 204 HIS   A CA  1 
ATOM   911  C  C   . HIS   A 1 204 ? -26.38342 -10.17408 30.81907 1.000 14.46555 ? 204 HIS   A C   1 
ATOM   912  O  O   . HIS   A 1 204 ? -26.45052 -10.78774 29.74762 1.000 14.66422 ? 204 HIS   A O   1 
ATOM   913  C  CB  . HIS   A 1 204 ? -24.34520 -8.75054  30.49096 1.000 11.68634 ? 204 HIS   A CB  1 
ATOM   914  C  CG  . HIS   A 1 204 ? -24.84118 -7.35199  30.69226 1.000 15.01466 ? 204 HIS   A CG  1 
ATOM   915  N  ND1 . HIS   A 1 204 ? -26.16357 -6.99826  30.53374 1.000 12.64529 ? 204 HIS   A ND1 1 
ATOM   916  C  CD2 . HIS   A 1 204 ? -24.18506 -6.21404  31.02170 1.000 10.42709 ? 204 HIS   A CD2 1 
ATOM   917  C  CE1 . HIS   A 1 204 ? -26.30269 -5.70513  30.76583 1.000 12.70964 ? 204 HIS   A CE1 1 
ATOM   918  N  NE2 . HIS   A 1 204 ? -25.11711 -5.20581  31.06492 1.000 13.26605 ? 204 HIS   A NE2 1 
ATOM   919  N  N   . PRO   A 1 205 ? -27.48400 -9.85273  31.50342 1.000 14.41801 ? 205 PRO   A N   1 
ATOM   920  C  CA  . PRO   A 1 205 ? -28.81065 -10.23376 31.00394 1.000 16.11119 ? 205 PRO   A CA  1 
ATOM   921  C  C   . PRO   A 1 205 ? -29.39395 -9.28305  29.97110 1.000 18.27822 ? 205 PRO   A C   1 
ATOM   922  O  O   . PRO   A 1 205 ? -30.51270 -9.52274  29.50347 1.000 19.15995 ? 205 PRO   A O   1 
ATOM   923  C  CB  . PRO   A 1 205 ? -29.65996 -10.23572 32.28081 1.000 19.28381 ? 205 PRO   A CB  1 
ATOM   924  C  CG  . PRO   A 1 205 ? -29.04017 -9.16950  33.11579 1.000 22.63254 ? 205 PRO   A CG  1 
ATOM   925  C  CD  . PRO   A 1 205 ? -27.55466 -9.24556  32.84339 1.000 13.98443 ? 205 PRO   A CD  1 
ATOM   926  N  N   . GLY   A 1 206 ? -28.68784 -8.21660  29.60600 1.000 17.07288 ? 206 GLY   A N   1 
ATOM   927  C  CA  . GLY   A 1 206 ? -29.19400 -7.30310  28.60236 1.000 20.89358 ? 206 GLY   A CA  1 
ATOM   928  C  C   . GLY   A 1 206 ? -30.10700 -6.21690  29.11899 1.000 19.51407 ? 206 GLY   A C   1 
ATOM   929  O  O   . GLY   A 1 206 ? -30.80633 -5.58265  28.32270 1.000 18.49589 ? 206 GLY   A O   1 
ATOM   930  N  N   . VAL   A 1 207 ? -30.13509 -5.98759  30.43228 1.000 14.93347 ? 207 VAL   A N   1 
ATOM   931  C  CA  . VAL   A 1 207 ? -30.87252 -4.88030  31.02266 1.000 16.20591 ? 207 VAL   A CA  1 
ATOM   932  C  C   . VAL   A 1 207 ? -29.94327 -4.13795  31.97376 1.000 19.22650 ? 207 VAL   A C   1 
ATOM   933  O  O   . VAL   A 1 207 ? -28.90833 -4.65401  32.40066 1.000 17.74182 ? 207 VAL   A O   1 
ATOM   934  C  CB  . VAL   A 1 207 ? -32.15120 -5.33902  31.75733 1.000 20.63828 ? 207 VAL   A CB  1 
ATOM   935  C  CG1 . VAL   A 1 207 ? -33.17876 -5.86599  30.76325 1.000 21.00128 ? 207 VAL   A CG1 1 
ATOM   936  C  CG2 . VAL   A 1 207 ? -31.81870 -6.39388  32.79977 1.000 19.25146 ? 207 VAL   A CG2 1 
ATOM   937  N  N   . SER   A 1 208 ? -30.33109 -2.90996  32.30585 1.000 16.46863 ? 208 SER   A N   1 
ATOM   938  C  CA  . SER   A 1 208 ? -29.47038 -2.01785  33.06476 1.000 16.99236 ? 208 SER   A CA  1 
ATOM   939  C  C   . SER   A 1 208 ? -29.58395 -2.28490  34.56520 1.000 15.52193 ? 208 SER   A C   1 
ATOM   940  O  O   . SER   A 1 208 ? -30.47069 -3.00219  35.03761 1.000 16.66426 ? 208 SER   A O   1 
ATOM   941  C  CB  . SER   A 1 208 ? -29.82000 -0.56123  32.76628 1.000 17.16733 ? 208 SER   A CB  1 
ATOM   942  O  OG  . SER   A 1 208 ? -31.10235 -0.23549  33.27465 1.000 18.07879 ? 208 SER   A OG  1 
ATOM   943  N  N   . ASN   A 1 209 ? -28.65502 -1.68732  35.31778 1.000 11.70471 ? 209 ASN   A N   1 
ATOM   944  C  CA  . ASN   A 1 209 ? -28.71714 -1.74572  36.77566 1.000 15.74066 ? 209 ASN   A CA  1 
ATOM   945  C  C   . ASN   A 1 209 ? -30.04076 -1.19656  37.28988 1.000 19.11056 ? 209 ASN   A C   1 
ATOM   946  O  O   . ASN   A 1 209 ? -30.69274 -1.81088  38.14215 1.000 16.13179 ? 209 ASN   A O   1 
ATOM   947  C  CB  . ASN   A 1 209 ? -27.55280 -0.96282  37.38643 1.000 13.60311 ? 209 ASN   A CB  1 
ATOM   948  C  CG  . ASN   A 1 209 ? -26.25814 -1.74597  37.39477 1.000 13.90830 ? 209 ASN   A CG  1 
ATOM   949  O  OD1 . ASN   A 1 209 ? -26.26314 -2.97486  37.41981 1.000 11.17873 ? 209 ASN   A OD1 1 
ATOM   950  N  ND2 . ASN   A 1 209 ? -25.13679 -1.03401  37.38449 1.000 11.50105 ? 209 ASN   A ND2 1 
ATOM   951  N  N   . GLN   A 1 210 ? -30.44973 -0.03034  36.78192 1.000 16.61222 ? 210 GLN   A N   1 
ATOM   952  C  CA  . GLN   A 1 210 ? -31.67028 0.60669   37.26627 1.000 20.82182 ? 210 GLN   A CA  1 
ATOM   953  C  C   . GLN   A 1 210 ? -32.88966 -0.27209  37.01780 1.000 19.11721 ? 210 GLN   A C   1 
ATOM   954  O  O   . GLN   A 1 210 ? -33.79765 -0.33708  37.85503 1.000 24.08679 ? 210 GLN   A O   1 
ATOM   955  C  CB  . GLN   A 1 210 ? -31.84529 1.97295   36.60269 1.000 18.33922 ? 210 GLN   A CB  1 
ATOM   956  C  CG  . GLN   A 1 210 ? -32.88007 2.85596   37.27513 1.000 24.52600 ? 210 GLN   A CG  1 
ATOM   957  C  CD  . GLN   A 1 210 ? -32.59654 3.05058   38.75020 1.000 25.83244 ? 210 GLN   A CD  1 
ATOM   958  O  OE1 . GLN   A 1 210 ? -31.64143 3.73009   39.12563 1.000 30.51748 ? 210 GLN   A OE1 1 
ATOM   959  N  NE2 . GLN   A 1 210 ? -33.42239 2.44638   39.59665 1.000 26.46892 ? 210 GLN   A NE2 1 
ATOM   960  N  N   . PHE   A 1 211 ? -32.92676 -0.95842  35.87244 1.000 18.65016 ? 211 PHE   A N   1 
ATOM   961  C  CA  . PHE   A 1 211 ? -34.01936 -1.88749  35.60163 1.000 18.72110 ? 211 PHE   A CA  1 
ATOM   962  C  C   . PHE   A 1 211 ? -34.01607 -3.03991  36.59774 1.000 23.17781 ? 211 PHE   A C   1 
ATOM   963  O  O   . PHE   A 1 211 ? -35.07149 -3.43152  37.11053 1.000 20.67948 ? 211 PHE   A O   1 
ATOM   964  C  CB  . PHE   A 1 211 ? -33.91746 -2.41080  34.16660 1.000 21.94791 ? 211 PHE   A CB  1 
ATOM   965  C  CG  . PHE   A 1 211 ? -34.94703 -3.45566  33.81994 1.000 23.41395 ? 211 PHE   A CG  1 
ATOM   966  C  CD1 . PHE   A 1 211 ? -34.71496 -4.79736  34.08809 1.000 20.18772 ? 211 PHE   A CD1 1 
ATOM   967  C  CD2 . PHE   A 1 211 ? -36.14181 -3.09773  33.21642 1.000 20.65980 ? 211 PHE   A CD2 1 
ATOM   968  C  CE1 . PHE   A 1 211 ? -35.65468 -5.75804  33.77213 1.000 21.66842 ? 211 PHE   A CE1 1 
ATOM   969  C  CE2 . PHE   A 1 211 ? -37.08688 -4.05646  32.89476 1.000 22.67742 ? 211 PHE   A CE2 1 
ATOM   970  C  CZ  . PHE   A 1 211 ? -36.84178 -5.38841  33.17316 1.000 23.26483 ? 211 PHE   A CZ  1 
ATOM   971  N  N   . LEU   A 1 212 ? -32.83789 -3.60656  36.87151 1.000 18.66592 ? 212 LEU   A N   1 
ATOM   972  C  CA  . LEU   A 1 212 ? -32.74210 -4.67195  37.86299 1.000 19.37820 ? 212 LEU   A CA  1 
ATOM   973  C  C   . LEU   A 1 212 ? -33.12538 -4.17357  39.24893 1.000 19.18667 ? 212 LEU   A C   1 
ATOM   974  O  O   . LEU   A 1 212 ? -33.68752 -4.93029  40.04895 1.000 20.55300 ? 212 LEU   A O   1 
ATOM   975  C  CB  . LEU   A 1 212 ? -31.32723 -5.25149  37.87211 1.000 16.76740 ? 212 LEU   A CB  1 
ATOM   976  C  CG  . LEU   A 1 212 ? -30.89264 -5.99033  36.60463 1.000 19.17259 ? 212 LEU   A CG  1 
ATOM   977  C  CD1 . LEU   A 1 212 ? -29.38775 -6.20771  36.59851 1.000 14.62581 ? 212 LEU   A CD1 1 
ATOM   978  C  CD2 . LEU   A 1 212 ? -31.62550 -7.31714  36.47725 1.000 14.13154 ? 212 LEU   A CD2 1 
ATOM   979  N  N   . ILE   A 1 213 ? -32.83619 -2.90551  39.54626 1.000 16.46669 ? 213 ILE   A N   1 
ATOM   980  C  CA  . ILE   A 1 213 ? -33.25435 -2.32075  40.81519 1.000 18.22747 ? 213 ILE   A CA  1 
ATOM   981  C  C   . ILE   A 1 213 ? -34.76615 -2.13036  40.84357 1.000 23.63251 ? 213 ILE   A C   1 
ATOM   982  O  O   . ILE   A 1 213 ? -35.42887 -2.45788  41.83522 1.000 19.43772 ? 213 ILE   A O   1 
ATOM   983  C  CB  . ILE   A 1 213 ? -32.51310 -0.99244  41.05382 1.000 16.94072 ? 213 ILE   A CB  1 
ATOM   984  C  CG1 . ILE   A 1 213 ? -31.01747 -1.24036  41.26001 1.000 17.85530 ? 213 ILE   A CG1 1 
ATOM   985  C  CG2 . ILE   A 1 213 ? -33.10661 -0.24954  42.24177 1.000 18.55389 ? 213 ILE   A CG2 1 
ATOM   986  C  CD1 . ILE   A 1 213 ? -30.19516 0.02789   41.31804 1.000 16.81473 ? 213 ILE   A CD1 1 
ATOM   987  N  N   . ASN   A 1 214 ? -35.33705 -1.60928  39.75377 1.000 21.61316 ? 214 ASN   A N   1 
ATOM   988  C  CA  . ASN   A 1 214 ? -36.75556 -1.26941  39.73308 1.000 25.55362 ? 214 ASN   A CA  1 
ATOM   989  C  C   . ASN   A 1 214 ? -37.65613 -2.49306  39.64376 1.000 24.69932 ? 214 ASN   A C   1 
ATOM   990  O  O   . ASN   A 1 214 ? -38.81676 -2.42072  40.06124 1.000 29.68053 ? 214 ASN   A O   1 
ATOM   991  C  CB  . ASN   A 1 214 ? -37.05368 -0.32761  38.56595 1.000 20.04244 ? 214 ASN   A CB  1 
ATOM   992  C  CG  . ASN   A 1 214 ? -36.49129 1.06075   38.78165 1.000 22.59545 ? 214 ASN   A CG  1 
ATOM   993  O  OD1 . ASN   A 1 214 ? -36.15312 1.43809   39.90368 1.000 25.40302 ? 214 ASN   A OD1 1 
ATOM   994  N  ND2 . ASN   A 1 214 ? -36.38883 1.83150   37.70524 1.000 24.52738 ? 214 ASN   A ND2 1 
ATOM   995  N  N   . THR   A 1 215 ? -37.16239 -3.60199  39.10187 1.000 22.89647 ? 215 THR   A N   1 
ATOM   996  C  CA  . THR   A 1 215 ? -37.93575 -4.83159  39.01846 1.000 24.61155 ? 215 THR   A CA  1 
ATOM   997  C  C   . THR   A 1 215 ? -37.69841 -5.74977  40.21038 1.000 23.85972 ? 215 THR   A C   1 
ATOM   998  O  O   . THR   A 1 215 ? -38.15326 -6.89899  40.19160 1.000 23.25938 ? 215 THR   A O   1 
ATOM   999  C  CB  . THR   A 1 215 ? -37.61867 -5.56684  37.71283 1.000 27.45806 ? 215 THR   A CB  1 
ATOM   1000 O  OG1 . THR   A 1 215 ? -36.21206 -5.82684  37.63514 1.000 24.05958 ? 215 THR   A OG1 1 
ATOM   1001 C  CG2 . THR   A 1 215 ? -38.03133 -4.71886  36.51869 1.000 24.60852 ? 215 THR   A CG2 1 
ATOM   1002 N  N   . ASN   A 1 216 ? -37.00327 -5.26224  41.23981 1.000 28.14280 ? 216 ASN   A N   1 
ATOM   1003 C  CA  . ASN   A 1 216 ? -36.73832 -6.01929  42.46313 1.000 24.07586 ? 216 ASN   A CA  1 
ATOM   1004 C  C   . ASN   A 1 216 ? -36.11471 -7.37357  42.13959 1.000 23.43375 ? 216 ASN   A C   1 
ATOM   1005 O  O   . ASN   A 1 216 ? -36.50238 -8.41620  42.67154 1.000 25.01594 ? 216 ASN   A O   1 
ATOM   1006 C  CB  . ASN   A 1 216 ? -38.01203 -6.17551  43.29310 1.000 28.87705 ? 216 ASN   A CB  1 
ATOM   1007 C  CG  . ASN   A 1 216 ? -38.70895 -4.85116  43.53949 1.000 36.03088 ? 216 ASN   A CG  1 
ATOM   1008 O  OD1 . ASN   A 1 216 ? -38.09596 -3.89037  44.00785 1.000 32.85856 ? 216 ASN   A OD1 1 
ATOM   1009 N  ND2 . ASN   A 1 216 ? -39.99567 -4.79121  43.21685 1.000 40.42238 ? 216 ASN   A ND2 1 
ATOM   1010 N  N   . SER   A 1 217 ? -35.13429 -7.34239  41.24334 1.000 21.48204 ? 217 SER   A N   1 
ATOM   1011 C  CA  . SER   A 1 217 ? -34.48092 -8.55307  40.78081 1.000 23.55160 ? 217 SER   A CA  1 
ATOM   1012 C  C   . SER   A 1 217 ? -33.70408 -9.21595  41.91257 1.000 23.54831 ? 217 SER   A C   1 
ATOM   1013 O  O   . SER   A 1 217 ? -33.31743 -8.58150  42.89898 1.000 20.16281 ? 217 SER   A O   1 
ATOM   1014 C  CB  . SER   A 1 217 ? -33.53603 -8.23719  39.62258 1.000 22.59341 ? 217 SER   A CB  1 
ATOM   1015 O  OG  . SER   A 1 217 ? -32.59650 -7.24505  39.99957 1.000 20.99432 ? 217 SER   A OG  1 
ATOM   1016 N  N   . GLU   A 1 218 ? -33.48259 -10.52235 41.75580 1.000 19.94347 ? 218 GLU   A N   1 
ATOM   1017 C  CA  . GLU   A 1 218 ? -32.61834 -11.24211 42.68236 1.000 19.70594 ? 218 GLU   A CA  1 
ATOM   1018 C  C   . GLU   A 1 218 ? -31.21224 -10.65642 42.69341 1.000 22.09129 ? 218 GLU   A C   1 
ATOM   1019 O  O   . GLU   A 1 218 ? -30.55226 -10.64324 43.73875 1.000 17.09938 ? 218 GLU   A O   1 
ATOM   1020 C  CB  . GLU   A 1 218 ? -32.58203 -12.72455 42.30538 1.000 25.55008 ? 218 GLU   A CB  1 
ATOM   1021 C  CG  . GLU   A 1 218 ? -32.37791 -13.68789 43.46912 1.000 35.99649 ? 218 GLU   A CG  1 
ATOM   1022 C  CD  . GLU   A 1 218 ? -33.38894 -13.50524 44.58914 1.000 44.97750 ? 218 GLU   A CD  1 
ATOM   1023 O  OE1 . GLU   A 1 218 ? -34.54132 -13.11591 44.30434 1.000 47.57082 ? 218 GLU   A OE1 1 
ATOM   1024 O  OE2 . GLU   A 1 218 ? -33.03211 -13.76866 45.75785 1.000 44.48918 ? 218 GLU   A OE2 1 
ATOM   1025 N  N   . LEU   A 1 219 ? -30.74702 -10.15462 41.54676 1.000 15.71200 ? 219 LEU   A N   1 
ATOM   1026 C  CA  . LEU   A 1 219 ? -29.41605 -9.56026  41.47040 1.000 17.78934 ? 219 LEU   A CA  1 
ATOM   1027 C  C   . LEU   A 1 219 ? -29.32834 -8.28821  42.30526 1.000 15.47449 ? 219 LEU   A C   1 
ATOM   1028 O  O   . LEU   A 1 219 ? -28.39100 -8.11616  43.09332 1.000 13.84702 ? 219 LEU   A O   1 
ATOM   1029 C  CB  . LEU   A 1 219 ? -29.05539 -9.27070  40.01303 1.000 16.60064 ? 219 LEU   A CB  1 
ATOM   1030 C  CG  . LEU   A 1 219 ? -28.55372 -10.44272 39.16953 1.000 24.46417 ? 219 LEU   A CG  1 
ATOM   1031 C  CD1 . LEU   A 1 219 ? -28.26123 -9.98985  37.74736 1.000 22.27848 ? 219 LEU   A CD1 1 
ATOM   1032 C  CD2 . LEU   A 1 219 ? -27.31589 -11.05533 39.80246 1.000 22.79527 ? 219 LEU   A CD2 1 
ATOM   1033 N  N   . ALA   A 1 220 ? -30.28791 -7.37347  42.13216 1.000 14.50727 ? 220 ALA   A N   1 
ATOM   1034 C  CA  . ALA   A 1 220 ? -30.29033 -6.15145  42.93095 1.000 19.04082 ? 220 ALA   A CA  1 
ATOM   1035 C  C   . ALA   A 1 220 ? -30.47262 -6.45751  44.41172 1.000 15.94674 ? 220 ALA   A C   1 
ATOM   1036 O  O   . ALA   A 1 220 ? -29.91034 -5.76014  45.26502 1.000 14.87912 ? 220 ALA   A O   1 
ATOM   1037 C  CB  . ALA   A 1 220 ? -31.38624 -5.20262  42.44416 1.000 15.85977 ? 220 ALA   A CB  1 
ATOM   1038 N  N   . LEU   A 1 221 ? -31.25100 -7.49591  44.73192 1.000 16.85944 ? 221 LEU   A N   1 
ATOM   1039 C  CA  . LEU   A 1 221 ? -31.40382 -7.92302  46.11900 1.000 17.53621 ? 221 LEU   A CA  1 
ATOM   1040 C  C   . LEU   A 1 221 ? -30.07527 -8.40283  46.68886 1.000 16.75206 ? 221 LEU   A C   1 
ATOM   1041 O  O   . LEU   A 1 221 ? -29.71810 -8.06528  47.82376 1.000 17.63257 ? 221 LEU   A O   1 
ATOM   1042 C  CB  . LEU   A 1 221 ? -32.46409 -9.02462  46.19792 1.000 19.25323 ? 221 LEU   A CB  1 
ATOM   1043 C  CG  . LEU   A 1 221 ? -33.12146 -9.49291  47.50440 1.000 29.07513 ? 221 LEU   A CG  1 
ATOM   1044 C  CD1 . LEU   A 1 221 ? -32.15661 -10.12434 48.50505 1.000 32.43176 ? 221 LEU   A CD1 1 
ATOM   1045 C  CD2 . LEU   A 1 221 ? -33.91815 -8.36103  48.14956 1.000 28.60609 ? 221 LEU   A CD2 1 
ATOM   1046 N  N   . MET   A 1 222 ? -29.32615 -9.18632  45.91018 1.000 14.51511 ? 222 MET   A N   1 
ATOM   1047 C  CA  . MET   A 1 222 ? -28.05674 -9.72055  46.39233 1.000 16.44239 ? 222 MET   A CA  1 
ATOM   1048 C  C   . MET   A 1 222 ? -27.03785 -8.61296  46.62970 1.000 14.71350 ? 222 MET   A C   1 
ATOM   1049 O  O   . MET   A 1 222 ? -26.30493 -8.63998  47.62497 1.000 12.26820 ? 222 MET   A O   1 
ATOM   1050 C  CB  . MET   A 1 222 ? -27.50770 -10.74176 45.39487 1.000 15.31370 ? 222 MET   A CB  1 
ATOM   1051 C  CG  . MET   A 1 222 ? -26.19019 -11.38331 45.81089 1.000 13.69950 ? 222 MET   A CG  1 
ATOM   1052 S  SD  . MET   A 1 222 ? -26.39435 -12.65219 47.07536 1.000 25.16526 ? 222 MET   A SD  1 
ATOM   1053 C  CE  . MET   A 1 222 ? -27.18699 -13.94653 46.12285 1.000 23.85100 ? 222 MET   A CE  1 
ATOM   1054 N  N   . TYR   A 1 223 ? -26.98166 -7.62642  45.73638 1.000 15.29388 ? 223 TYR   A N   1 
ATOM   1055 C  CA  . TYR   A 1 223 ? -25.91059 -6.63950  45.74255 1.000 12.80306 ? 223 TYR   A CA  1 
ATOM   1056 C  C   . TYR   A 1 223 ? -26.35446 -5.27053  46.24079 1.000 11.22478 ? 223 TYR   A C   1 
ATOM   1057 O  O   . TYR   A 1 223 ? -25.61549 -4.29429  46.07220 1.000 11.54616 ? 223 TYR   A O   1 
ATOM   1058 C  CB  . TYR   A 1 223 ? -25.29602 -6.53923  44.34614 1.000 11.93085 ? 223 TYR   A CB  1 
ATOM   1059 C  CG  . TYR   A 1 223 ? -24.46576 -7.75565  44.02154 1.000 12.44375 ? 223 TYR   A CG  1 
ATOM   1060 C  CD1 . TYR   A 1 223 ? -23.31182 -8.03041  44.74061 1.000 11.27279 ? 223 TYR   A CD1 1 
ATOM   1061 C  CD2 . TYR   A 1 223 ? -24.84446 -8.64319  43.02221 1.000 13.94059 ? 223 TYR   A CD2 1 
ATOM   1062 C  CE1 . TYR   A 1 223 ? -22.54860 -9.14305  44.46826 1.000 13.76032 ? 223 TYR   A CE1 1 
ATOM   1063 C  CE2 . TYR   A 1 223 ? -24.08363 -9.76449  42.73986 1.000 13.11199 ? 223 TYR   A CE2 1 
ATOM   1064 C  CZ  . TYR   A 1 223 ? -22.93514 -10.00731 43.46781 1.000 13.97835 ? 223 TYR   A CZ  1 
ATOM   1065 O  OH  . TYR   A 1 223 ? -22.16721 -11.11737 43.20047 1.000 11.65700 ? 223 TYR   A OH  1 
ATOM   1066 N  N   . ASN   A 1 224 ? -27.53485 -5.18049  46.85617 1.000 10.01924 ? 224 ASN   A N   1 
ATOM   1067 C  CA  . ASN   A 1 224 ? -27.96890 -3.98027  47.57446 1.000 13.68473 ? 224 ASN   A CA  1 
ATOM   1068 C  C   . ASN   A 1 224 ? -27.90115 -2.73481  46.69139 1.000 13.48012 ? 224 ASN   A C   1 
ATOM   1069 O  O   . ASN   A 1 224 ? -27.46504 -1.66329  47.11974 1.000 12.38834 ? 224 ASN   A O   1 
ATOM   1070 C  CB  . ASN   A 1 224 ? -27.15397 -3.79646  48.85664 1.000 12.57438 ? 224 ASN   A CB  1 
ATOM   1071 C  CG  . ASN   A 1 224 ? -27.30604 -4.96703  49.81498 1.000 13.62129 ? 224 ASN   A CG  1 
ATOM   1072 O  OD1 . ASN   A 1 224 ? -28.41926 -5.33144  50.19496 1.000 17.51757 ? 224 ASN   A OD1 1 
ATOM   1073 N  ND2 . ASN   A 1 224 ? -26.18571 -5.56942  50.19952 1.000 12.47886 ? 224 ASN   A ND2 1 
ATOM   1074 N  N   . ASP   A 1 225 ? -28.31867 -2.89274  45.43435 1.000 12.91767 ? 225 ASP   A N   1 
ATOM   1075 C  CA  . ASP   A 1 225 ? -28.53897 -1.82055  44.46537 1.000 16.42599 ? 225 ASP   A CA  1 
ATOM   1076 C  C   . ASP   A 1 225 ? -27.26860 -1.09413  44.03849 1.000 15.59625 ? 225 ASP   A C   1 
ATOM   1077 O  O   . ASP   A 1 225 ? -27.36033 -0.07798  43.33770 1.000 15.53233 ? 225 ASP   A O   1 
ATOM   1078 C  CB  . ASP   A 1 225 ? -29.54481 -0.78685  44.98712 1.000 13.77711 ? 225 ASP   A CB  1 
ATOM   1079 C  CG  . ASP   A 1 225 ? -30.91376 -1.38243  45.24606 1.000 14.30624 ? 225 ASP   A CG  1 
ATOM   1080 O  OD1 . ASP   A 1 225 ? -31.17868 -2.50701  44.77146 1.000 15.76498 ? 225 ASP   A OD1 1 
ATOM   1081 O  OD2 . ASP   A 1 225 ? -31.72841 -0.72030  45.92171 1.000 16.87356 ? 225 ASP   A OD2 1 
ATOM   1082 N  N   . SER   A 1 226 ? -26.08886 -1.57688  44.41922 1.000 12.85638 ? 226 SER   A N   1 
ATOM   1083 C  CA  . SER   A 1 226 ? -24.83388 -0.88640  44.13828 1.000 13.08621 ? 226 SER   A CA  1 
ATOM   1084 C  C   . SER   A 1 226 ? -24.00209 -1.70782  43.16241 1.000 13.84948 ? 226 SER   A C   1 
ATOM   1085 O  O   . SER   A 1 226 ? -23.56411 -2.81406  43.49888 1.000 13.60510 ? 226 SER   A O   1 
ATOM   1086 C  CB  . SER   A 1 226 ? -24.04900 -0.63615  45.42579 1.000 15.68777 ? 226 SER   A CB  1 
ATOM   1087 O  OG  . SER   A 1 226 ? -24.89536 -0.13977  46.44760 1.000 28.70440 ? 226 SER   A OG  1 
ATOM   1088 N  N   . SER   A 1 227 ? -23.76972 -1.15248  41.97171 1.000 15.11529 ? 227 SER   A N   1 
ATOM   1089 C  CA  . SER   A 1 227 ? -22.99544 -1.80769  40.91475 1.000 12.48055 ? 227 SER   A CA  1 
ATOM   1090 C  C   . SER   A 1 227 ? -23.41324 -3.26683  40.76354 1.000 12.54354 ? 227 SER   A C   1 
ATOM   1091 O  O   . SER   A 1 227 ? -22.59158 -4.18653  40.77289 1.000 11.91750 ? 227 SER   A O   1 
ATOM   1092 C  CB  . SER   A 1 227 ? -21.49449 -1.68960  41.17947 1.000 16.29077 ? 227 SER   A CB  1 
ATOM   1093 O  OG  . SER   A 1 227 ? -21.07655 -0.33532  41.18716 1.000 14.22311 ? 227 SER   A OG  1 
ATOM   1094 N  N   . VAL   A 1 228 ? -24.72716 -3.46379  40.63050 1.000 10.07864 ? 228 VAL   A N   1 
ATOM   1095 C  CA  . VAL   A 1 228 ? -25.30745 -4.80377  40.68474 1.000 10.73756 ? 228 VAL   A CA  1 
ATOM   1096 C  C   . VAL   A 1 228 ? -24.70470 -5.69637  39.60776 1.000 12.47227 ? 228 VAL   A C   1 
ATOM   1097 O  O   . VAL   A 1 228 ? -24.21765 -6.79768  39.88999 1.000 11.56234 ? 228 VAL   A O   1 
ATOM   1098 C  CB  . VAL   A 1 228 ? -26.83868 -4.72349  40.55743 1.000 13.71599 ? 228 VAL   A CB  1 
ATOM   1099 C  CG1 . VAL   A 1 228 ? -27.42515 -6.10958  40.40566 1.000 12.30406 ? 228 VAL   A CG1 1 
ATOM   1100 C  CG2 . VAL   A 1 228 ? -27.43360 -4.01514  41.76316 1.000 12.91479 ? 228 VAL   A CG2 1 
ATOM   1101 N  N   . LEU   A 1 229 ? -24.73271 -5.23414  38.35624 1.000 10.71897 ? 229 LEU   A N   1 
ATOM   1102 C  CA  . LEU   A 1 229 ? -24.17758 -6.01775  37.25702 1.000 13.82506 ? 229 LEU   A CA  1 
ATOM   1103 C  C   . LEU   A 1 229 ? -22.68451 -6.24830  37.44354 1.000 11.04596 ? 229 LEU   A C   1 
ATOM   1104 O  O   . LEU   A 1 229 ? -22.19438 -7.37595  37.31032 1.000 12.24830 ? 229 LEU   A O   1 
ATOM   1105 C  CB  . LEU   A 1 229 ? -24.43702 -5.30776  35.92847 1.000 13.03649 ? 229 LEU   A CB  1 
ATOM   1106 C  CG  . LEU   A 1 229 ? -25.85295 -5.33651  35.36093 1.000 19.53913 ? 229 LEU   A CG  1 
ATOM   1107 C  CD1 . LEU   A 1 229 ? -26.03318 -4.22396  34.34124 1.000 14.43589 ? 229 LEU   A CD1 1 
ATOM   1108 C  CD2 . LEU   A 1 229 ? -26.11569 -6.68174  34.73044 1.000 15.38165 ? 229 LEU   A CD2 1 
ATOM   1109 N  N   . GLU   A 1 230 ? -21.94719 -5.18163  37.75898 1.000 10.15069 ? 230 GLU   A N   1 
ATOM   1110 C  CA  . GLU   A 1 230 ? -20.48992 -5.24906  37.76790 1.000 13.86034 ? 230 GLU   A CA  1 
ATOM   1111 C  C   . GLU   A 1 230 ? -19.98004 -6.16366  38.87488 1.000 11.73248 ? 230 GLU   A C   1 
ATOM   1112 O  O   . GLU   A 1 230 ? -19.01055 -6.90497  38.67491 1.000 13.24555 ? 230 GLU   A O   1 
ATOM   1113 C  CB  . GLU   A 1 230 ? -19.90680 -3.84137  37.90338 1.000 7.97431  ? 230 GLU   A CB  1 
ATOM   1114 C  CG  . GLU   A 1 230 ? -20.16842 -2.93530  36.69633 1.000 12.39349 ? 230 GLU   A CG  1 
ATOM   1115 C  CD  . GLU   A 1 230 ? -21.61154 -2.45994  36.60351 1.000 14.34912 ? 230 GLU   A CD  1 
ATOM   1116 O  OE1 . GLU   A 1 230 ? -22.30205 -2.44099  37.64503 1.000 8.53348  ? 230 GLU   A OE1 1 
ATOM   1117 O  OE2 . GLU   A 1 230 ? -22.05752 -2.11566  35.48752 1.000 13.84696 ? 230 GLU   A OE2 1 
ATOM   1118 N  N   . ASN   A 1 231 ? -20.61617 -6.12798  40.04821 1.000 10.53050 ? 231 ASN   A N   1 
ATOM   1119 C  CA  . ASN   A 1 231 ? -20.29386 -7.10598  41.08197 1.000 11.87021 ? 231 ASN   A CA  1 
ATOM   1120 C  C   . ASN   A 1 231 ? -20.60024 -8.52080  40.60888 1.000 13.94030 ? 231 ASN   A C   1 
ATOM   1121 O  O   . ASN   A 1 231 ? -19.84884 -9.45854  40.90194 1.000 13.03853 ? 231 ASN   A O   1 
ATOM   1122 C  CB  . ASN   A 1 231 ? -21.06302 -6.79554  42.36608 1.000 11.40426 ? 231 ASN   A CB  1 
ATOM   1123 C  CG  . ASN   A 1 231 ? -20.35813 -5.77769  43.23850 1.000 17.50979 ? 231 ASN   A CG  1 
ATOM   1124 O  OD1 . ASN   A 1 231 ? -19.33202 -6.07506  43.85066 1.000 18.33036 ? 231 ASN   A OD1 1 
ATOM   1125 N  ND2 . ASN   A 1 231 ? -20.91002 -4.57055  43.30730 1.000 9.90457  ? 231 ASN   A ND2 1 
ATOM   1126 N  N   . HIS   A 1 232 ? -21.69872 -8.69335  39.86964 1.000 10.50133 ? 232 HIS   A N   1 
ATOM   1127 C  CA  . HIS   A 1 232 ? -22.06341 -10.02075 39.38601 1.000 12.97691 ? 232 HIS   A CA  1 
ATOM   1128 C  C   . HIS   A 1 232 ? -21.06095 -10.52750 38.35711 1.000 13.67313 ? 232 HIS   A C   1 
ATOM   1129 O  O   . HIS   A 1 232 ? -20.64770 -11.69213 38.40393 1.000 13.98376 ? 232 HIS   A O   1 
ATOM   1130 C  CB  . HIS   A 1 232 ? -23.47232 -10.00218 38.79378 1.000 13.13929 ? 232 HIS   A CB  1 
ATOM   1131 C  CG  . HIS   A 1 232 ? -23.93398 -11.33955 38.30447 1.000 11.67663 ? 232 HIS   A CG  1 
ATOM   1132 N  ND1 . HIS   A 1 232 ? -24.09640 -12.42157 39.14268 1.000 12.25816 ? 232 HIS   A ND1 1 
ATOM   1133 C  CD2 . HIS   A 1 232 ? -24.25655 -11.77366 37.06300 1.000 13.46947 ? 232 HIS   A CD2 1 
ATOM   1134 C  CE1 . HIS   A 1 232 ? -24.50527 -13.46284 38.44027 1.000 13.71661 ? 232 HIS   A CE1 1 
ATOM   1135 N  NE2 . HIS   A 1 232 ? -24.61004 -13.09644 37.17552 1.000 14.35257 ? 232 HIS   A NE2 1 
ATOM   1136 N  N   . HIS   A 1 233 ? -20.67070 -9.66903  37.40929 1.000 11.22294 ? 233 HIS   A N   1 
ATOM   1137 C  CA  . HIS   A 1 233 ? -19.67353 -10.05540 36.41453 1.000 12.71962 ? 233 HIS   A CA  1 
ATOM   1138 C  C   . HIS   A 1 233 ? -18.40596 -10.56888 37.08572 1.000 15.07420 ? 233 HIS   A C   1 
ATOM   1139 O  O   . HIS   A 1 233 ? -17.84944 -11.60064 36.69262 1.000 11.55958 ? 233 HIS   A O   1 
ATOM   1140 C  CB  . HIS   A 1 233 ? -19.34127 -8.87000  35.50346 1.000 13.02656 ? 233 HIS   A CB  1 
ATOM   1141 C  CG  . HIS   A 1 233 ? -20.53176 -8.25401  34.83547 1.000 13.31693 ? 233 HIS   A CG  1 
ATOM   1142 N  ND1 . HIS   A 1 233 ? -21.55726 -8.99966  34.29593 1.000 13.25523 ? 233 HIS   A ND1 1 
ATOM   1143 C  CD2 . HIS   A 1 233 ? -20.85229 -6.95763  34.61047 1.000 8.21958  ? 233 HIS   A CD2 1 
ATOM   1144 C  CE1 . HIS   A 1 233 ? -22.46010 -8.18937  33.77185 1.000 10.30452 ? 233 HIS   A CE1 1 
ATOM   1145 N  NE2 . HIS   A 1 233 ? -22.05559 -6.94476  33.94864 1.000 13.78290 ? 233 HIS   A NE2 1 
ATOM   1146 N  N   . LEU   A 1 234 ? -17.93853 -9.85399  38.11056 1.000 13.37798 ? 234 LEU   A N   1 
ATOM   1147 C  CA  . LEU   A 1 234 ? -16.73442 -10.26751 38.82295 1.000 13.86165 ? 234 LEU   A CA  1 
ATOM   1148 C  C   . LEU   A 1 234 ? -16.93738 -11.60824 39.51482 1.000 11.82879 ? 234 LEU   A C   1 
ATOM   1149 O  O   . LEU   A 1 234 ? -16.08938 -12.50353 39.41965 1.000 13.45123 ? 234 LEU   A O   1 
ATOM   1150 C  CB  . LEU   A 1 234 ? -16.33630 -9.19506  39.83608 1.000 10.50038 ? 234 LEU   A CB  1 
ATOM   1151 C  CG  . LEU   A 1 234 ? -15.63001 -7.96214  39.27636 1.000 10.92379 ? 234 LEU   A CG  1 
ATOM   1152 C  CD1 . LEU   A 1 234 ? -15.77094 -6.78217  40.22376 1.000 10.61785 ? 234 LEU   A CD1 1 
ATOM   1153 C  CD2 . LEU   A 1 234 ? -14.16412 -8.27311  39.02149 1.000 9.68187  ? 234 LEU   A CD2 1 
ATOM   1154 N  N   . ALA   A 1 235 ? -18.06159 -11.76234 40.21996 1.000 10.87841 ? 235 ALA   A N   1 
ATOM   1155 C  CA  . ALA   A 1 235 ? -18.32205 -13.00534 40.93846 1.000 15.87558 ? 235 ALA   A CA  1 
ATOM   1156 C  C   . ALA   A 1 235 ? -18.34183 -14.19646 39.99106 1.000 14.52885 ? 235 ALA   A C   1 
ATOM   1157 O  O   . ALA   A 1 235 ? -17.82810 -15.26932 40.32356 1.000 14.43773 ? 235 ALA   A O   1 
ATOM   1158 C  CB  . ALA   A 1 235 ? -19.64078 -12.90515 41.70512 1.000 12.43758 ? 235 ALA   A CB  1 
ATOM   1159 N  N   . VAL   A 1 236 ? -18.91381 -14.02153 38.79886 1.000 11.73145 ? 236 VAL   A N   1 
ATOM   1160 C  CA  . VAL   A 1 236 ? -18.95838 -15.11028 37.82737 1.000 11.39844 ? 236 VAL   A CA  1 
ATOM   1161 C  C   . VAL   A 1 236 ? -17.57084 -15.37134 37.25255 1.000 13.47765 ? 236 VAL   A C   1 
ATOM   1162 O  O   . VAL   A 1 236 ? -17.12466 -16.52162 37.16462 1.000 13.10733 ? 236 VAL   A O   1 
ATOM   1163 C  CB  . VAL   A 1 236 ? -19.97818 -14.79731 36.71794 1.000 15.90383 ? 236 VAL   A CB  1 
ATOM   1164 C  CG1 . VAL   A 1 236 ? -19.83791 -15.78976 35.57444 1.000 14.18024 ? 236 VAL   A CG1 1 
ATOM   1165 C  CG2 . VAL   A 1 236 ? -21.39240 -14.81896 37.27757 1.000 12.96814 ? 236 VAL   A CG2 1 
ATOM   1166 N  N   . GLY   A 1 237 ? -16.86777 -14.30724 36.85600 1.000 12.76705 ? 237 GLY   A N   1 
ATOM   1167 C  CA  . GLY   A 1 237 ? -15.56773 -14.48083 36.22542 1.000 10.59250 ? 237 GLY   A CA  1 
ATOM   1168 C  C   . GLY   A 1 237 ? -14.55545 -15.15833 37.12933 1.000 11.83858 ? 237 GLY   A C   1 
ATOM   1169 O  O   . GLY   A 1 237 ? -13.76525 -15.99076 36.67722 1.000 14.34626 ? 237 GLY   A O   1 
ATOM   1170 N  N   . PHE   A 1 238 ? -14.56336 -14.81165 38.41901 1.000 10.23554 ? 238 PHE   A N   1 
ATOM   1171 C  CA  . PHE   A 1 238 ? -13.65986 -15.46450 39.36139 1.000 14.78477 ? 238 PHE   A CA  1 
ATOM   1172 C  C   . PHE   A 1 238 ? -14.12453 -16.87937 39.68627 1.000 12.89040 ? 238 PHE   A C   1 
ATOM   1173 O  O   . PHE   A 1 238 ? -13.29978 -17.78545 39.85075 1.000 17.59713 ? 238 PHE   A O   1 
ATOM   1174 C  CB  . PHE   A 1 238 ? -13.54379 -14.64313 40.64666 1.000 11.82902 ? 238 PHE   A CB  1 
ATOM   1175 C  CG  . PHE   A 1 238 ? -12.72806 -13.38931 40.50443 1.000 12.90975 ? 238 PHE   A CG  1 
ATOM   1176 C  CD1 . PHE   A 1 238 ? -11.39215 -13.45019 40.14159 1.000 15.86608 ? 238 PHE   A CD1 1 
ATOM   1177 C  CD2 . PHE   A 1 238 ? -13.29033 -12.15121 40.76553 1.000 14.88162 ? 238 PHE   A CD2 1 
ATOM   1178 C  CE1 . PHE   A 1 238 ? -10.63796 -12.29676 40.02141 1.000 17.37107 ? 238 PHE   A CE1 1 
ATOM   1179 C  CE2 . PHE   A 1 238 ? -12.54191 -10.99551 40.64993 1.000 15.39611 ? 238 PHE   A CE2 1 
ATOM   1180 C  CZ  . PHE   A 1 238 ? -11.21347 -11.06877 40.27790 1.000 15.33472 ? 238 PHE   A CZ  1 
ATOM   1181 N  N   . LYS   A 1 239 ? -15.44111 -17.08585 39.78589 1.000 11.66621 ? 239 LYS   A N   1 
ATOM   1182 C  CA  . LYS   A 1 239 ? -15.96999 -18.39083 40.17680 1.000 16.17419 ? 239 LYS   A CA  1 
ATOM   1183 C  C   . LYS   A 1 239 ? -15.65711 -19.45767 39.13460 1.000 18.30991 ? 239 LYS   A C   1 
ATOM   1184 O  O   . LYS   A 1 239 ? -15.38407 -20.61267 39.48322 1.000 18.71399 ? 239 LYS   A O   1 
ATOM   1185 C  CB  . LYS   A 1 239 ? -17.47891 -18.29090 40.40550 1.000 16.75316 ? 239 LYS   A CB  1 
ATOM   1186 C  CG  . LYS   A 1 239 ? -18.19750 -19.61553 40.59410 1.000 29.12538 ? 239 LYS   A CG  1 
ATOM   1187 C  CD  . LYS   A 1 239 ? -17.92235 -20.21401 41.96100 1.000 35.78028 ? 239 LYS   A CD  1 
ATOM   1188 C  CE  . LYS   A 1 239 ? -18.75015 -21.46975 42.17709 1.000 38.67530 ? 239 LYS   A CE  1 
ATOM   1189 N  NZ  . LYS   A 1 239 ? -18.44721 -22.12215 43.47967 1.000 33.63668 ? 239 LYS   A NZ  1 
ATOM   1190 N  N   . LEU   A 1 240 ? -15.69069 -19.09176 37.85130 1.000 16.74536 ? 240 LEU   A N   1 
ATOM   1191 C  CA  . LEU   A 1 240 ? -15.43554 -20.06026 36.79204 1.000 15.64874 ? 240 LEU   A CA  1 
ATOM   1192 C  C   . LEU   A 1 240 ? -13.99395 -20.55015 36.78561 1.000 17.08275 ? 240 LEU   A C   1 
ATOM   1193 O  O   . LEU   A 1 240 ? -13.71587 -21.60293 36.20246 1.000 19.74978 ? 240 LEU   A O   1 
ATOM   1194 C  CB  . LEU   A 1 240 ? -15.79523 -19.45685 35.43403 1.000 14.80119 ? 240 LEU   A CB  1 
ATOM   1195 C  CG  . LEU   A 1 240 ? -17.28710 -19.18267 35.23463 1.000 15.95778 ? 240 LEU   A CG  1 
ATOM   1196 C  CD1 . LEU   A 1 240 ? -17.52378 -18.31349 34.01106 1.000 12.06148 ? 240 LEU   A CD1 1 
ATOM   1197 C  CD2 . LEU   A 1 240 ? -18.05496 -20.49122 35.12324 1.000 13.71152 ? 240 LEU   A CD2 1 
ATOM   1198 N  N   . LEU   A 1 241 ? -13.07501 -19.81911 37.42235 1.000 17.24382 ? 241 LEU   A N   1 
ATOM   1199 C  CA  . LEU   A 1 241 ? -11.70975 -20.30960 37.57583 1.000 20.22988 ? 241 LEU   A CA  1 
ATOM   1200 C  C   . LEU   A 1 241 ? -11.65141 -21.60246 38.37749 1.000 20.51100 ? 241 LEU   A C   1 
ATOM   1201 O  O   . LEU   A 1 241 ? -10.65685 -22.33031 38.29016 1.000 22.18172 ? 241 LEU   A O   1 
ATOM   1202 C  CB  . LEU   A 1 241 ? -10.83763 -19.25194 38.25594 1.000 17.06812 ? 241 LEU   A CB  1 
ATOM   1203 C  CG  . LEU   A 1 241 ? -10.61047 -17.91559 37.54922 1.000 16.87958 ? 241 LEU   A CG  1 
ATOM   1204 C  CD1 . LEU   A 1 241 ? -10.04297 -16.90121 38.52876 1.000 16.53457 ? 241 LEU   A CD1 1 
ATOM   1205 C  CD2 . LEU   A 1 241 ? -9.67742  -18.08928 36.36328 1.000 17.33244 ? 241 LEU   A CD2 1 
ATOM   1206 N  N   . GLN   A 1 242 ? -12.69003 -21.90275 39.15218 1.000 16.74865 ? 242 GLN   A N   1 
ATOM   1207 C  CA  . GLN   A 1 242 ? -12.71155 -23.06923 40.02149 1.000 18.96632 ? 242 GLN   A CA  1 
ATOM   1208 C  C   . GLN   A 1 242 ? -13.33590 -24.29450 39.36571 1.000 24.69436 ? 242 GLN   A C   1 
ATOM   1209 O  O   . GLN   A 1 242 ? -13.40493 -25.35018 40.00355 1.000 23.67954 ? 242 GLN   A O   1 
ATOM   1210 C  CB  . GLN   A 1 242 ? -13.45189 -22.73134 41.31890 1.000 23.00697 ? 242 GLN   A CB  1 
ATOM   1211 C  CG  . GLN   A 1 242 ? -12.72602 -21.70050 42.17119 1.000 25.41138 ? 242 GLN   A CG  1 
ATOM   1212 C  CD  . GLN   A 1 242 ? -13.57022 -21.17923 43.31663 1.000 32.92347 ? 242 GLN   A CD  1 
ATOM   1213 O  OE1 . GLN   A 1 242 ? -14.68048 -21.65506 43.55282 1.000 39.35098 ? 242 GLN   A OE1 1 
ATOM   1214 N  NE2 . GLN   A 1 242 ? -13.04543 -20.19330 44.03615 1.000 35.64418 ? 242 GLN   A NE2 1 
ATOM   1215 N  N   . GLU   A 1 243 ? -13.78793 -24.18650 38.11866 1.000 22.64741 ? 243 GLU   A N   1 
ATOM   1216 C  CA  . GLU   A 1 243 ? -14.28250 -25.35075 37.40340 1.000 20.73465 ? 243 GLU   A CA  1 
ATOM   1217 C  C   . GLU   A 1 243 ? -13.11134 -26.22335 36.95174 1.000 21.58764 ? 243 GLU   A C   1 
ATOM   1218 O  O   . GLU   A 1 243 ? -11.94083 -25.85110 37.07267 1.000 22.81505 ? 243 GLU   A O   1 
ATOM   1219 C  CB  . GLU   A 1 243 ? -15.14144 -24.92575 36.21253 1.000 18.48312 ? 243 GLU   A CB  1 
ATOM   1220 C  CG  . GLU   A 1 243 ? -16.30412 -24.00917 36.58077 1.000 22.13322 ? 243 GLU   A CG  1 
ATOM   1221 C  CD  . GLU   A 1 243 ? -17.34127 -24.68717 37.46032 1.000 31.15550 ? 243 GLU   A CD  1 
ATOM   1222 O  OE1 . GLU   A 1 243 ? -17.57291 -25.90183 37.28507 1.000 30.67518 ? 243 GLU   A OE1 1 
ATOM   1223 O  OE2 . GLU   A 1 243 ? -17.92760 -24.00319 38.32625 1.000 33.68501 ? 243 GLU   A OE2 1 
ATOM   1224 N  N   . GLU   A 1 244 ? -13.44146 -27.40039 36.42174 1.000 21.59150 ? 244 GLU   A N   1 
ATOM   1225 C  CA  . GLU   A 1 244 ? -12.42925 -28.40656 36.11723 1.000 23.59860 ? 244 GLU   A CA  1 
ATOM   1226 C  C   . GLU   A 1 244 ? -11.42165 -27.88573 35.09808 1.000 19.04486 ? 244 GLU   A C   1 
ATOM   1227 O  O   . GLU   A 1 244 ? -11.79069 -27.50719 33.98127 1.000 17.59059 ? 244 GLU   A O   1 
ATOM   1228 C  CB  . GLU   A 1 244 ? -13.09717 -29.67984 35.60203 1.000 21.35908 ? 244 GLU   A CB  1 
ATOM   1229 C  CG  . GLU   A 1 244 ? -12.15955 -30.87074 35.50029 1.000 23.44071 ? 244 GLU   A CG  1 
ATOM   1230 C  CD  . GLU   A 1 244 ? -12.76117 -32.00929 34.70530 1.000 28.50958 ? 244 GLU   A CD  1 
ATOM   1231 O  OE1 . GLU   A 1 244 ? -13.10558 -33.04784 35.30744 1.000 31.42325 ? 244 GLU   A OE1 1 
ATOM   1232 O  OE2 . GLU   A 1 244 ? -12.89903 -31.85584 33.47491 1.000 28.61861 ? 244 GLU   A OE2 1 
ATOM   1233 N  N   . ASN   A 1 245 ? -10.14765 -27.87706 35.49508 1.000 18.17052 ? 245 ASN   A N   1 
ATOM   1234 C  CA  . ASN   A 1 245 ? -9.03710  -27.42418 34.65535 1.000 18.16967 ? 245 ASN   A CA  1 
ATOM   1235 C  C   . ASN   A 1 245 ? -9.29143  -26.02025 34.10886 1.000 18.84846 ? 245 ASN   A C   1 
ATOM   1236 O  O   . ASN   A 1 245 ? -9.12190  -25.74422 32.91950 1.000 18.70787 ? 245 ASN   A O   1 
ATOM   1237 C  CB  . ASN   A 1 245 ? -8.76549  -28.41516 33.52111 1.000 20.20000 ? 245 ASN   A CB  1 
ATOM   1238 C  CG  . ASN   A 1 245 ? -7.43212  -28.16697 32.83658 1.000 22.57806 ? 245 ASN   A CG  1 
ATOM   1239 O  OD1 . ASN   A 1 245 ? -6.51961  -27.58261 33.42148 1.000 23.95085 ? 245 ASN   A OD1 1 
ATOM   1240 N  ND2 . ASN   A 1 245 ? -7.31718  -28.60464 31.58815 1.000 26.52237 ? 245 ASN   A ND2 1 
ATOM   1241 N  N   . CYS   A 1 246 ? -9.69914  -25.11748 34.99983 1.000 21.86410 ? 246 CYS   A N   1 
ATOM   1242 C  CA  . CYS   A 1 246 ? -10.01769 -23.75368 34.60930 1.000 20.22560 ? 246 CYS   A CA  1 
ATOM   1243 C  C   . CYS   A 1 246 ? -9.20323  -22.68714 35.32619 1.000 20.07416 ? 246 CYS   A C   1 
ATOM   1244 O  O   . CYS   A 1 246 ? -9.31832  -21.51036 34.96640 1.000 17.65720 ? 246 CYS   A O   1 
ATOM   1245 C  CB  . CYS   A 1 246 ? -11.51087 -23.46518 34.83366 1.000 15.62538 ? 246 CYS   A CB  1 
ATOM   1246 S  SG  . CYS   A 1 246 ? -12.60688 -24.10832 33.54786 1.000 18.33535 ? 246 CYS   A SG  1 
ATOM   1247 N  N   . ASP   A 1 247 ? -8.38910  -23.04527 36.31586 1.000 22.79459 ? 247 ASP   A N   1 
ATOM   1248 C  CA  . ASP   A 1 247 ? -7.62776  -22.04031 37.05677 1.000 19.06914 ? 247 ASP   A CA  1 
ATOM   1249 C  C   . ASP   A 1 247 ? -6.39281  -21.66470 36.24723 1.000 24.04001 ? 247 ASP   A C   1 
ATOM   1250 O  O   . ASP   A 1 247 ? -5.32151  -22.25805 36.38467 1.000 19.33935 ? 247 ASP   A O   1 
ATOM   1251 C  CB  . ASP   A 1 247 ? -7.25455  -22.54750 38.44322 1.000 20.42078 ? 247 ASP   A CB  1 
ATOM   1252 C  CG  . ASP   A 1 247 ? -6.65469  -21.45935 39.31394 1.000 24.58459 ? 247 ASP   A CG  1 
ATOM   1253 O  OD1 . ASP   A 1 247 ? -6.71038  -20.27719 38.91013 1.000 17.26443 ? 247 ASP   A OD1 1 
ATOM   1254 O  OD2 . ASP   A 1 247 ? -6.13533  -21.78142 40.40223 1.000 23.77655 ? 247 ASP   A OD2 1 
ATOM   1255 N  N   . ILE   A 1 248 ? -6.54589  -20.64857 35.39415 1.000 17.28717 ? 248 ILE   A N   1 
ATOM   1256 C  CA  . ILE   A 1 248 ? -5.42789  -20.14670 34.60408 1.000 19.02497 ? 248 ILE   A CA  1 
ATOM   1257 C  C   . ILE   A 1 248 ? -4.40209  -19.40269 35.44356 1.000 18.17284 ? 248 ILE   A C   1 
ATOM   1258 O  O   . ILE   A 1 248 ? -3.32468  -19.07060 34.93715 1.000 18.02229 ? 248 ILE   A O   1 
ATOM   1259 C  CB  . ILE   A 1 248 ? -5.94166  -19.23239 33.47439 1.000 15.90977 ? 248 ILE   A CB  1 
ATOM   1260 C  CG1 . ILE   A 1 248 ? -6.70804  -18.04513 34.05941 1.000 16.85883 ? 248 ILE   A CG1 1 
ATOM   1261 C  CG2 . ILE   A 1 248 ? -6.83113  -20.01436 32.52578 1.000 19.44960 ? 248 ILE   A CG2 1 
ATOM   1262 C  CD1 . ILE   A 1 248 ? -6.92114  -16.91221 33.07954 1.000 14.48044 ? 248 ILE   A CD1 1 
ATOM   1263 N  N   . PHE   A 1 249 ? -4.70848  -19.12868 36.71215 1.000 19.86726 ? 249 PHE   A N   1 
ATOM   1264 C  CA  . PHE   A 1 249 ? -3.78338  -18.47451 37.62678 1.000 20.48538 ? 249 PHE   A CA  1 
ATOM   1265 C  C   . PHE   A 1 249 ? -3.13075  -19.45976 38.59193 1.000 25.26101 ? 249 PHE   A C   1 
ATOM   1266 O  O   . PHE   A 1 249 ? -2.61257  -19.04617 39.63480 1.000 20.82130 ? 249 PHE   A O   1 
ATOM   1267 C  CB  . PHE   A 1 249 ? -4.50357  -17.37521 38.41040 1.000 20.01106 ? 249 PHE   A CB  1 
ATOM   1268 C  CG  . PHE   A 1 249 ? -5.23546  -16.38768 37.54509 1.000 18.43964 ? 249 PHE   A CG  1 
ATOM   1269 C  CD1 . PHE   A 1 249 ? -4.55141  -15.60753 36.62780 1.000 20.42798 ? 249 PHE   A CD1 1 
ATOM   1270 C  CD2 . PHE   A 1 249 ? -6.60782  -16.23075 37.65909 1.000 17.54425 ? 249 PHE   A CD2 1 
ATOM   1271 C  CE1 . PHE   A 1 249 ? -5.22321  -14.69512 35.83324 1.000 21.79221 ? 249 PHE   A CE1 1 
ATOM   1272 C  CE2 . PHE   A 1 249 ? -7.28540  -15.31976 36.86830 1.000 17.75519 ? 249 PHE   A CE2 1 
ATOM   1273 C  CZ  . PHE   A 1 249 ? -6.59199  -14.55084 35.95480 1.000 14.86929 ? 249 PHE   A CZ  1 
ATOM   1274 N  N   . GLN   A 1 250 ? -3.13294  -20.75260 38.25575 1.000 19.43382 ? 250 GLN   A N   1 
ATOM   1275 C  CA  . GLN   A 1 250 ? -2.73117  -21.78740 39.20325 1.000 27.14691 ? 250 GLN   A CA  1 
ATOM   1276 C  C   . GLN   A 1 250 ? -1.25130  -21.73388 39.56342 1.000 22.74319 ? 250 GLN   A C   1 
ATOM   1277 O  O   . GLN   A 1 250 ? -0.86101  -22.29948 40.59039 1.000 24.43614 ? 250 GLN   A O   1 
ATOM   1278 C  CB  . GLN   A 1 250 ? -3.06897  -23.16891 38.64116 1.000 18.88338 ? 250 GLN   A CB  1 
ATOM   1279 C  CG  . GLN   A 1 250 ? -2.34938  -23.49890 37.34360 1.000 21.03702 ? 250 GLN   A CG  1 
ATOM   1280 C  CD  . GLN   A 1 250 ? -2.74411  -24.85228 36.78524 1.000 29.18863 ? 250 GLN   A CD  1 
ATOM   1281 O  OE1 . GLN   A 1 250 ? -1.97747  -25.81320 36.85695 1.000 23.94940 ? 250 GLN   A OE1 1 
ATOM   1282 N  NE2 . GLN   A 1 250 ? -3.94585  -24.93420 36.22307 1.000 21.36503 ? 250 GLN   A NE2 1 
ATOM   1283 N  N   . ASN   A 1 251 ? -0.41879  -21.08274 38.75233 1.000 19.74336 ? 251 ASN   A N   1 
ATOM   1284 C  CA  . ASN   A 1 251 ? 1.01531   -21.03003 39.00602 1.000 21.25854 ? 251 ASN   A CA  1 
ATOM   1285 C  C   . ASN   A 1 251 ? 1.49643   -19.63989 39.39631 1.000 25.16652 ? 251 ASN   A C   1 
ATOM   1286 O  O   . ASN   A 1 251 ? 2.70867   -19.40639 39.45154 1.000 20.56893 ? 251 ASN   A O   1 
ATOM   1287 C  CB  . ASN   A 1 251 ? 1.78924   -21.53915 37.78935 1.000 17.95603 ? 251 ASN   A CB  1 
ATOM   1288 C  CG  . ASN   A 1 251 ? 1.60503   -23.02683 37.56911 1.000 23.07569 ? 251 ASN   A CG  1 
ATOM   1289 O  OD1 . ASN   A 1 251 ? 1.42071   -23.78752 38.52037 1.000 23.84697 ? 251 ASN   A OD1 1 
ATOM   1290 N  ND2 . ASN   A 1 251 ? 1.65362   -23.45071 36.31263 1.000 22.23858 ? 251 ASN   A ND2 1 
ATOM   1291 N  N   . LEU   A 1 252 ? 0.58376   -18.71366 39.66552 1.000 19.78743 ? 252 LEU   A N   1 
ATOM   1292 C  CA  . LEU   A 1 252 ? 0.96904   -17.45227 40.27305 1.000 24.88777 ? 252 LEU   A CA  1 
ATOM   1293 C  C   . LEU   A 1 252 ? 1.23419   -17.66130 41.75716 1.000 22.74820 ? 252 LEU   A C   1 
ATOM   1294 O  O   . LEU   A 1 252 ? 0.66429   -18.55361 42.39193 1.000 23.24391 ? 252 LEU   A O   1 
ATOM   1295 C  CB  . LEU   A 1 252 ? -0.11898  -16.39277 40.08271 1.000 24.14866 ? 252 LEU   A CB  1 
ATOM   1296 C  CG  . LEU   A 1 252 ? -0.14442  -15.57818 38.78569 1.000 21.50344 ? 252 LEU   A CG  1 
ATOM   1297 C  CD1 . LEU   A 1 252 ? -0.36013  -16.46429 37.56616 1.000 20.00831 ? 252 LEU   A CD1 1 
ATOM   1298 C  CD2 . LEU   A 1 252 ? -1.21531  -14.49957 38.86110 1.000 21.88206 ? 252 LEU   A CD2 1 
ATOM   1299 N  N   . THR   A 1 253 ? 2.12271   -16.84010 42.30562 1.000 24.15125 ? 253 THR   A N   1 
ATOM   1300 C  CA  . THR   A 1 253 ? 2.32160   -16.84400 43.74367 1.000 24.54059 ? 253 THR   A CA  1 
ATOM   1301 C  C   . THR   A 1 253 ? 1.05632   -16.34565 44.43866 1.000 25.78322 ? 253 THR   A C   1 
ATOM   1302 O  O   . THR   A 1 253 ? 0.17033   -15.74949 43.81893 1.000 19.99918 ? 253 THR   A O   1 
ATOM   1303 C  CB  . THR   A 1 253 ? 3.52019   -15.97338 44.12640 1.000 26.46836 ? 253 THR   A CB  1 
ATOM   1304 O  OG1 . THR   A 1 253 ? 3.23385   -14.60003 43.83810 1.000 19.63757 ? 253 THR   A OG1 1 
ATOM   1305 C  CG2 . THR   A 1 253 ? 4.76104   -16.40226 43.35212 1.000 26.31113 ? 253 THR   A CG2 1 
ATOM   1306 N  N   . LYS   A 1 254 ? 0.96673   -16.61982 45.74284 1.000 23.43154 ? 254 LYS   A N   1 
ATOM   1307 C  CA  . LYS   A 1 254 ? -0.15501  -16.10899 46.52568 1.000 28.85262 ? 254 LYS   A CA  1 
ATOM   1308 C  C   . LYS   A 1 254 ? -0.25632  -14.59386 46.41795 1.000 27.22388 ? 254 LYS   A C   1 
ATOM   1309 O  O   . LYS   A 1 254 ? -1.35444  -14.04463 46.27037 1.000 27.53117 ? 254 LYS   A O   1 
ATOM   1310 C  CB  . LYS   A 1 254 ? -0.00766  -16.52071 47.98897 1.000 31.07634 ? 254 LYS   A CB  1 
ATOM   1311 C  CG  . LYS   A 1 254 ? -0.59165  -17.87598 48.33296 1.000 38.47458 ? 254 LYS   A CG  1 
ATOM   1312 C  CD  . LYS   A 1 254 ? 0.15983   -18.48236 49.49865 1.000 43.90699 ? 254 LYS   A CD  1 
ATOM   1313 C  CE  . LYS   A 1 254 ? 1.56094   -18.86975 49.07782 1.000 44.18935 ? 254 LYS   A CE  1 
ATOM   1314 N  NZ  . LYS   A 1 254 ? 2.56515   -18.51743 50.10944 1.000 46.42457 ? 254 LYS   A NZ  1 
ATOM   1315 N  N   . LYS   A 1 255 ? 0.88231   -13.90193 46.48599 1.000 25.26018 ? 255 LYS   A N   1 
ATOM   1316 C  CA  . LYS   A 1 255 ? 0.86909   -12.44460 46.42977 1.000 27.86018 ? 255 LYS   A CA  1 
ATOM   1317 C  C   . LYS   A 1 255 ? 0.46469   -11.94604 45.04814 1.000 23.97879 ? 255 LYS   A C   1 
ATOM   1318 O  O   . LYS   A 1 255 ? -0.23546  -10.93332 44.93093 1.000 20.75576 ? 255 LYS   A O   1 
ATOM   1319 C  CB  . LYS   A 1 255 ? 2.23838   -11.89743 46.83107 1.000 23.54743 ? 255 LYS   A CB  1 
ATOM   1320 C  CG  . LYS   A 1 255 ? 2.54712   -12.07883 48.30956 1.000 37.97132 ? 255 LYS   A CG  1 
ATOM   1321 C  CD  . LYS   A 1 255 ? 3.97835   -11.70135 48.65077 1.000 45.51718 ? 255 LYS   A CD  1 
ATOM   1322 C  CE  . LYS   A 1 255 ? 4.21506   -11.79687 50.15063 1.000 52.26761 ? 255 LYS   A CE  1 
ATOM   1323 N  NZ  . LYS   A 1 255 ? 5.61359   -11.45255 50.52372 1.000 54.05679 ? 255 LYS   A NZ  1 
ATOM   1324 N  N   . GLN   A 1 256 ? 0.89626   -12.63989 43.99036 1.000 21.27365 ? 256 GLN   A N   1 
ATOM   1325 C  CA  . GLN   A 1 256 ? 0.45446   -12.28067 42.64589 1.000 23.46486 ? 256 GLN   A CA  1 
ATOM   1326 C  C   . GLN   A 1 256 ? -1.05348  -12.44205 42.50189 1.000 22.97542 ? 256 GLN   A C   1 
ATOM   1327 O  O   . GLN   A 1 256 ? -1.71998  -11.60121 41.88694 1.000 22.50396 ? 256 GLN   A O   1 
ATOM   1328 C  CB  . GLN   A 1 256 ? 1.17951   -13.13075 41.60189 1.000 20.25762 ? 256 GLN   A CB  1 
ATOM   1329 C  CG  . GLN   A 1 256 ? 2.63601   -12.76083 41.37404 1.000 25.89316 ? 256 GLN   A CG  1 
ATOM   1330 C  CD  . GLN   A 1 256 ? 3.35322   -13.76900 40.49771 1.000 22.63343 ? 256 GLN   A CD  1 
ATOM   1331 O  OE1 . GLN   A 1 256 ? 3.06047   -14.96314 40.54336 1.000 21.19650 ? 256 GLN   A OE1 1 
ATOM   1332 N  NE2 . GLN   A 1 256 ? 4.29481   -13.29297 39.69150 1.000 29.29728 ? 256 GLN   A NE2 1 
ATOM   1333 N  N   . ARG   A 1 257 ? -1.60949  -13.51725 43.06606 1.000 18.53258 ? 257 ARG   A N   1 
ATOM   1334 C  CA  . ARG   A 1 257 ? -3.04523  -13.75548 42.95450 1.000 23.11202 ? 257 ARG   A CA  1 
ATOM   1335 C  C   . ARG   A 1 257 ? -3.84080  -12.74217 43.77035 1.000 20.10510 ? 257 ARG   A C   1 
ATOM   1336 O  O   . ARG   A 1 257 ? -4.86793  -12.23483 43.30367 1.000 16.97321 ? 257 ARG   A O   1 
ATOM   1337 C  CB  . ARG   A 1 257 ? -3.36798  -15.18686 43.38537 1.000 19.37337 ? 257 ARG   A CB  1 
ATOM   1338 C  CG  . ARG   A 1 257 ? -2.83403  -16.24329 42.42386 1.000 22.44844 ? 257 ARG   A CG  1 
ATOM   1339 C  CD  . ARG   A 1 257 ? -2.76826  -17.62335 43.06290 1.000 26.77747 ? 257 ARG   A CD  1 
ATOM   1340 N  NE  . ARG   A 1 257 ? -4.08004  -18.12063 43.46334 1.000 29.91538 ? 257 ARG   A NE  1 
ATOM   1341 C  CZ  . ARG   A 1 257 ? -4.76900  -19.03601 42.79017 1.000 29.50328 ? 257 ARG   A CZ  1 
ATOM   1342 N  NH1 . ARG   A 1 257 ? -4.27165  -19.55849 41.67771 1.000 28.95468 ? 257 ARG   A NH1 1 
ATOM   1343 N  NH2 . ARG   A 1 257 ? -5.95543  -19.43070 43.23057 1.000 34.36834 ? 257 ARG   A NH2 1 
ATOM   1344 N  N   . GLN   A 1 258 ? -3.38537  -12.43904 44.99047 1.000 19.12341 ? 258 GLN   A N   1 
ATOM   1345 C  CA  . GLN   A 1 258 ? -3.99104  -11.36181 45.77040 1.000 21.29964 ? 258 GLN   A CA  1 
ATOM   1346 C  C   . GLN   A 1 258 ? -3.99558  -10.05705 44.98829 1.000 14.66781 ? 258 GLN   A C   1 
ATOM   1347 O  O   . GLN   A 1 258 ? -5.03676  -9.40580  44.84299 1.000 16.79740 ? 258 GLN   A O   1 
ATOM   1348 C  CB  . GLN   A 1 258 ? -3.23027  -11.15879 47.07922 1.000 22.99426 ? 258 GLN   A CB  1 
ATOM   1349 C  CG  . GLN   A 1 258 ? -3.50524  -12.14789 48.18243 1.000 33.01967 ? 258 GLN   A CG  1 
ATOM   1350 C  CD  . GLN   A 1 258 ? -2.66231  -11.84335 49.40412 1.000 42.84715 ? 258 GLN   A CD  1 
ATOM   1351 O  OE1 . GLN   A 1 258 ? -1.89327  -12.68307 49.87120 1.000 47.25017 ? 258 GLN   A OE1 1 
ATOM   1352 N  NE2 . GLN   A 1 258 ? -2.78585  -10.62232 49.91433 1.000 31.23832 ? 258 GLN   A NE2 1 
ATOM   1353 N  N   . SER   A 1 259 ? -2.82248  -9.65222  44.49511 1.000 15.76757 ? 259 SER   A N   1 
ATOM   1354 C  CA  . SER   A 1 259 ? -2.69632  -8.37468  43.80314 1.000 19.22029 ? 259 SER   A CA  1 
ATOM   1355 C  C   . SER   A 1 259 ? -3.54206  -8.34215  42.53856 1.000 13.88735 ? 259 SER   A C   1 
ATOM   1356 O  O   . SER   A 1 259 ? -4.20145  -7.33636  42.25101 1.000 14.97027 ? 259 SER   A O   1 
ATOM   1357 C  CB  . SER   A 1 259 ? -1.22773  -8.10508  43.47443 1.000 19.39182 ? 259 SER   A CB  1 
ATOM   1358 O  OG  . SER   A 1 259 ? -1.09004  -6.99713  42.60237 1.000 20.94367 ? 259 SER   A OG  1 
ATOM   1359 N  N   . LEU   A 1 260 ? -3.53672  -9.43169  41.76835 1.000 15.75583 ? 260 LEU   A N   1 
ATOM   1360 C  CA  . LEU   A 1 260 ? -4.33638  -9.46733  40.54896 1.000 13.79494 ? 260 LEU   A CA  1 
ATOM   1361 C  C   . LEU   A 1 260 ? -5.82338  -9.39056  40.86752 1.000 13.12572 ? 260 LEU   A C   1 
ATOM   1362 O  O   . LEU   A 1 260 ? -6.56958  -8.64879  40.21806 1.000 16.34950 ? 260 LEU   A O   1 
ATOM   1363 C  CB  . LEU   A 1 260 ? -4.02808  -10.72744 39.74181 1.000 13.37521 ? 260 LEU   A CB  1 
ATOM   1364 C  CG  . LEU   A 1 260 ? -4.90208  -10.85362 38.49006 1.000 17.94648 ? 260 LEU   A CG  1 
ATOM   1365 C  CD1 . LEU   A 1 260 ? -4.05489  -11.04758 37.24218 1.000 20.53891 ? 260 LEU   A CD1 1 
ATOM   1366 C  CD2 . LEU   A 1 260 ? -5.92159  -11.97739 38.63634 1.000 15.68668 ? 260 LEU   A CD2 1 
ATOM   1367 N  N   . ARG   A 1 261 ? -6.27367  -10.15492 41.86668 1.000 13.36384 ? 261 ARG   A N   1 
ATOM   1368 C  CA  . ARG   A 1 261 ? -7.69362  -10.16330 42.20664 1.000 12.05942 ? 261 ARG   A CA  1 
ATOM   1369 C  C   . ARG   A 1 261 ? -8.18085  -8.76655  42.57153 1.000 14.01504 ? 261 ARG   A C   1 
ATOM   1370 O  O   . ARG   A 1 261 ? -9.24008  -8.32844  42.10915 1.000 13.23560 ? 261 ARG   A O   1 
ATOM   1371 C  CB  . ARG   A 1 261 ? -7.96637  -11.14422 43.34863 1.000 11.24251 ? 261 ARG   A CB  1 
ATOM   1372 C  CG  . ARG   A 1 261 ? -9.42375  -11.15270 43.79886 1.000 15.79688 ? 261 ARG   A CG  1 
ATOM   1373 C  CD  . ARG   A 1 261 ? -9.71879  -12.26334 44.79749 1.000 12.17152 ? 261 ARG   A CD  1 
ATOM   1374 N  NE  . ARG   A 1 261 ? -10.98628 -12.03527 45.48870 1.000 14.19799 ? 261 ARG   A NE  1 
ATOM   1375 C  CZ  . ARG   A 1 261 ? -12.18026 -12.33231 44.98481 1.000 12.33704 ? 261 ARG   A CZ  1 
ATOM   1376 N  NH1 . ARG   A 1 261 ? -12.27920 -12.87590 43.77912 1.000 11.99082 ? 261 ARG   A NH1 1 
ATOM   1377 N  NH2 . ARG   A 1 261 ? -13.27764 -12.08380 45.68634 1.000 15.84407 ? 261 ARG   A NH2 1 
ATOM   1378 N  N   . LYS   A 1 262 ? -7.41299  -8.04429  43.39270 1.000 15.36486 ? 262 LYS   A N   1 
ATOM   1379 C  CA  . LYS   A 1 262 ? -7.82152  -6.69528  43.77379 1.000 14.51525 ? 262 LYS   A CA  1 
ATOM   1380 C  C   . LYS   A 1 262 ? -7.83877  -5.76012  42.57128 1.000 13.57269 ? 262 LYS   A C   1 
ATOM   1381 O  O   . LYS   A 1 262 ? -8.76948  -4.96162  42.41131 1.000 14.36000 ? 262 LYS   A O   1 
ATOM   1382 C  CB  . LYS   A 1 262 ? -6.90055  -6.13843  44.85865 1.000 13.41019 ? 262 LYS   A CB  1 
ATOM   1383 C  CG  . LYS   A 1 262 ? -7.24332  -4.70403  45.23724 1.000 15.21373 ? 262 LYS   A CG  1 
ATOM   1384 C  CD  . LYS   A 1 262 ? -6.26420  -4.11265  46.23115 1.000 24.01178 ? 262 LYS   A CD  1 
ATOM   1385 C  CE  . LYS   A 1 262 ? -6.74224  -2.74842  46.70463 1.000 26.04765 ? 262 LYS   A CE  1 
ATOM   1386 N  NZ  . LYS   A 1 262 ? -8.02961  -2.84303  47.44947 1.000 33.33525 ? 262 LYS   A NZ  1 
ATOM   1387 N  N   . MET   A 1 263 ? -6.81494  -5.83891  41.71709 1.000 13.34081 ? 263 MET   A N   1 
ATOM   1388 C  CA  . MET   A 1 263 ? -6.76735  -4.97078  40.54472 1.000 11.60935 ? 263 MET   A CA  1 
ATOM   1389 C  C   . MET   A 1 263 ? -7.92772  -5.25502  39.59922 1.000 11.86049 ? 263 MET   A C   1 
ATOM   1390 O  O   . MET   A 1 263 ? -8.53106  -4.32625  39.04943 1.000 9.67665  ? 263 MET   A O   1 
ATOM   1391 C  CB  . MET   A 1 263 ? -5.42886  -5.13165  39.82192 1.000 13.23956 ? 263 MET   A CB  1 
ATOM   1392 C  CG  . MET   A 1 263 ? -4.24445  -4.53693  40.57068 1.000 12.17618 ? 263 MET   A CG  1 
ATOM   1393 S  SD  . MET   A 1 263 ? -2.75675  -4.41173  39.55742 1.000 15.46754 ? 263 MET   A SD  1 
ATOM   1394 C  CE  . MET   A 1 263 ? -2.25664  -6.12875  39.45289 1.000 11.14568 ? 263 MET   A CE  1 
ATOM   1395 N  N   . VAL   A 1 264 ? -8.26079  -6.53315  39.40504 1.000 12.72128 ? 264 VAL   A N   1 
ATOM   1396 C  CA  . VAL   A 1 264 ? -9.37424  -6.88769  38.52831 1.000 10.80543 ? 264 VAL   A CA  1 
ATOM   1397 C  C   . VAL   A 1 264 ? -10.68817 -6.36807  39.09876 1.000 9.22621  ? 264 VAL   A C   1 
ATOM   1398 O  O   . VAL   A 1 264 ? -11.54373 -5.85905  38.36376 1.000 11.72944 ? 264 VAL   A O   1 
ATOM   1399 C  CB  . VAL   A 1 264 ? -9.41109  -8.41122  38.30317 1.000 10.01670 ? 264 VAL   A CB  1 
ATOM   1400 C  CG1 . VAL   A 1 264 ? -10.72319 -8.82580  37.65775 1.000 10.94446 ? 264 VAL   A CG1 1 
ATOM   1401 C  CG2 . VAL   A 1 264 ? -8.23579  -8.84413  37.44049 1.000 11.77060 ? 264 VAL   A CG2 1 
ATOM   1402 N  N   . ILE   A 1 265 ? -10.86472 -6.47767  40.41758 1.000 10.41039 ? 265 ILE   A N   1 
ATOM   1403 C  CA  . ILE   A 1 265 ? -12.06782 -5.94995  41.05762 1.000 11.82162 ? 265 ILE   A CA  1 
ATOM   1404 C  C   . ILE   A 1 265 ? -12.14133 -4.43801  40.88457 1.000 12.38919 ? 265 ILE   A C   1 
ATOM   1405 O  O   . ILE   A 1 265 ? -13.18001 -3.88945  40.49695 1.000 9.13067  ? 265 ILE   A O   1 
ATOM   1406 C  CB  . ILE   A 1 265 ? -12.10501 -6.34885  42.54377 1.000 11.86147 ? 265 ILE   A CB  1 
ATOM   1407 C  CG1 . ILE   A 1 265 ? -12.32329 -7.85594  42.68922 1.000 11.25700 ? 265 ILE   A CG1 1 
ATOM   1408 C  CG2 . ILE   A 1 265 ? -13.19012 -5.57450  43.27997 1.000 13.24730 ? 265 ILE   A CG2 1 
ATOM   1409 C  CD1 . ILE   A 1 265 ? -12.01033 -8.38422  44.07071 1.000 8.22862  ? 265 ILE   A CD1 1 
ATOM   1410 N  N   . ASP   A 1 266 ? -11.03632 -3.74266  41.16975 1.000 10.98330 ? 266 ASP   A N   1 
ATOM   1411 C  CA  . ASP   A 1 266 ? -11.01383 -2.29017  41.02268 1.000 11.65580 ? 266 ASP   A CA  1 
ATOM   1412 C  C   . ASP   A 1 266 ? -11.34344 -1.87056  39.59522 1.000 10.01713 ? 266 ASP   A C   1 
ATOM   1413 O  O   . ASP   A 1 266 ? -12.03700 -0.87015  39.37887 1.000 9.51646  ? 266 ASP   A O   1 
ATOM   1414 C  CB  . ASP   A 1 266 ? -9.64773  -1.73879  41.43405 1.000 11.87134 ? 266 ASP   A CB  1 
ATOM   1415 C  CG  . ASP   A 1 266 ? -9.39307  -1.85271  42.92512 1.000 13.30232 ? 266 ASP   A CG  1 
ATOM   1416 O  OD1 . ASP   A 1 266 ? -10.35851 -2.07899  43.68374 1.000 11.27798 ? 266 ASP   A OD1 1 
ATOM   1417 O  OD2 . ASP   A 1 266 ? -8.22405  -1.70695  43.33953 1.000 12.25316 ? 266 ASP   A OD2 1 
ATOM   1418 N  N   . ILE   A 1 267 ? -10.86659 -2.63029  38.60815 1.000 12.30737 ? 267 ILE   A N   1 
ATOM   1419 C  CA  . ILE   A 1 267 ? -11.05676 -2.24332  37.21325 1.000 10.71456 ? 267 ILE   A CA  1 
ATOM   1420 C  C   . ILE   A 1 267 ? -12.50483 -2.45704  36.78462 1.000 10.77026 ? 267 ILE   A C   1 
ATOM   1421 O  O   . ILE   A 1 267 ? -13.13543 -1.56047  36.21258 1.000 10.47986 ? 267 ILE   A O   1 
ATOM   1422 C  CB  . ILE   A 1 267 ? -10.07830 -3.01007  36.30545 1.000 11.31265 ? 267 ILE   A CB  1 
ATOM   1423 C  CG1 . ILE   A 1 267 ? -8.65392  -2.47771  36.48589 1.000 13.17082 ? 267 ILE   A CG1 1 
ATOM   1424 C  CG2 . ILE   A 1 267 ? -10.50629 -2.90433  34.85137 1.000 6.96603  ? 267 ILE   A CG2 1 
ATOM   1425 C  CD1 . ILE   A 1 267 ? -7.59198  -3.33206  35.82643 1.000 9.24868  ? 267 ILE   A CD1 1 
ATOM   1426 N  N   . VAL   A 1 268 ? -13.05444 -3.64482  37.05147 1.000 10.03203 ? 268 VAL   A N   1 
ATOM   1427 C  CA  . VAL   A 1 268 ? -14.39370 -3.96343  36.56138 1.000 10.48624 ? 268 VAL   A CA  1 
ATOM   1428 C  C   . VAL   A 1 268 ? -15.44216 -3.08864  37.23899 1.000 11.24842 ? 268 VAL   A C   1 
ATOM   1429 O  O   . VAL   A 1 268 ? -16.39832 -2.63555  36.59715 1.000 9.89719  ? 268 VAL   A O   1 
ATOM   1430 C  CB  . VAL   A 1 268 ? -14.69378 -5.46143  36.74979 1.000 12.63895 ? 268 VAL   A CB  1 
ATOM   1431 C  CG1 . VAL   A 1 268 ? -16.16584 -5.74761  36.48977 1.000 9.55752  ? 268 VAL   A CG1 1 
ATOM   1432 C  CG2 . VAL   A 1 268 ? -13.82445 -6.29427  35.82231 1.000 8.84060  ? 268 VAL   A CG2 1 
ATOM   1433 N  N   . LEU   A 1 269 ? -15.28305 -2.83121  38.54015 1.000 11.87844 ? 269 LEU   A N   1 
ATOM   1434 C  CA  . LEU   A 1 269 ? -16.22157 -1.95096  39.22973 1.000 11.69476 ? 269 LEU   A CA  1 
ATOM   1435 C  C   . LEU   A 1 269 ? -16.21516 -0.55006  38.63367 1.000 15.19391 ? 269 LEU   A C   1 
ATOM   1436 O  O   . LEU   A 1 269 ? -17.22934 0.15493   38.69426 1.000 14.63170 ? 269 LEU   A O   1 
ATOM   1437 C  CB  . LEU   A 1 269 ? -15.89943 -1.89869  40.72331 1.000 11.63502 ? 269 LEU   A CB  1 
ATOM   1438 C  CG  . LEU   A 1 269 ? -16.25067 -3.16141  41.51115 1.000 11.54381 ? 269 LEU   A CG  1 
ATOM   1439 C  CD1 . LEU   A 1 269 ? -15.87185 -3.00674  42.97657 1.000 13.69289 ? 269 LEU   A CD1 1 
ATOM   1440 C  CD2 . LEU   A 1 269 ? -17.73023 -3.48081  41.36634 1.000 14.31083 ? 269 LEU   A CD2 1 
ATOM   1441 N  N   . ALA   A 1 270 ? -15.09417 -0.13695  38.04111 1.000 13.25891 ? 270 ALA   A N   1 
ATOM   1442 C  CA  . ALA   A 1 270 ? -15.00018 1.16756   37.40107 1.000 15.26814 ? 270 ALA   A CA  1 
ATOM   1443 C  C   . ALA   A 1 270 ? -15.70374 1.22563   36.05058 1.000 15.17141 ? 270 ALA   A C   1 
ATOM   1444 O  O   . ALA   A 1 270 ? -15.81149 2.31512   35.47815 1.000 9.98963  ? 270 ALA   A O   1 
ATOM   1445 C  CB  . ALA   A 1 270 ? -13.53241 1.56639   37.23187 1.000 15.22241 ? 270 ALA   A CB  1 
ATOM   1446 N  N   . THR   A 1 271 ? -16.17624 0.09421   35.52217 1.000 10.92286 ? 271 THR   A N   1 
ATOM   1447 C  CA  . THR   A 1 271 ? -16.95118 0.11908   34.28755 1.000 11.78867 ? 271 THR   A CA  1 
ATOM   1448 C  C   . THR   A 1 271 ? -18.40729 0.50094   34.51549 1.000 12.96341 ? 271 THR   A C   1 
ATOM   1449 O  O   . THR   A 1 271 ? -19.12721 0.73797   33.53934 1.000 15.80080 ? 271 THR   A O   1 
ATOM   1450 C  CB  . THR   A 1 271 ? -16.88424 -1.23681  33.57723 1.000 11.97033 ? 271 THR   A CB  1 
ATOM   1451 O  OG1 . THR   A 1 271 ? -17.33515 -2.26973  34.46188 1.000 11.79448 ? 271 THR   A OG1 1 
ATOM   1452 C  CG2 . THR   A 1 271 ? -15.46141 -1.53544  33.12834 1.000 8.96063  ? 271 THR   A CG2 1 
ATOM   1453 N  N   . ASP   A 1 272 ? -18.85563 0.55617   35.76786 1.000 11.35788 ? 272 ASP   A N   1 
ATOM   1454 C  CA  . ASP   A 1 272 ? -20.18003 1.08066   36.07336 1.000 14.15804 ? 272 ASP   A CA  1 
ATOM   1455 C  C   . ASP   A 1 272 ? -20.26477 2.53356   35.62427 1.000 15.29467 ? 272 ASP   A C   1 
ATOM   1456 O  O   . ASP   A 1 272 ? -19.53554 3.39108   36.13235 1.000 13.17782 ? 272 ASP   A O   1 
ATOM   1457 C  CB  . ASP   A 1 272 ? -20.45572 0.96066   37.57402 1.000 15.27971 ? 272 ASP   A CB  1 
ATOM   1458 C  CG  . ASP   A 1 272 ? -21.89888 1.28591   37.94175 1.000 15.38196 ? 272 ASP   A CG  1 
ATOM   1459 O  OD1 . ASP   A 1 272 ? -22.63321 1.85240   37.10511 1.000 14.29709 ? 272 ASP   A OD1 1 
ATOM   1460 O  OD2 . ASP   A 1 272 ? -22.30021 0.97477   39.08249 1.000 14.32178 ? 272 ASP   A OD2 1 
ATOM   1461 N  N   . MET   A 1 273 ? -21.15661 2.80921   34.66855 1.000 16.75069 ? 273 MET   A N   1 
ATOM   1462 C  CA  . MET   A 1 273 ? -21.25245 4.15394   34.11088 1.000 16.76401 ? 273 MET   A CA  1 
ATOM   1463 C  C   . MET   A 1 273 ? -21.69897 5.18658   35.13614 1.000 17.35728 ? 273 MET   A C   1 
ATOM   1464 O  O   . MET   A 1 273 ? -21.43767 6.37916   34.94646 1.000 17.60295 ? 273 MET   A O   1 
ATOM   1465 C  CB  . MET   A 1 273 ? -22.20542 4.16521   32.91523 1.000 19.06831 ? 273 MET   A CB  1 
ATOM   1466 C  CG  . MET   A 1 273 ? -21.51252 3.96153   31.58106 1.000 23.72612 ? 273 MET   A CG  1 
ATOM   1467 S  SD  . MET   A 1 273 ? -20.40486 5.31172   31.15203 1.000 31.91268 ? 273 MET   A SD  1 
ATOM   1468 C  CE  . MET   A 1 273 ? -21.59058 6.60100   30.80103 1.000 17.99492 ? 273 MET   A CE  1 
ATOM   1469 N  N   . SER   A 1 274 ? -22.35550 4.76699   36.21954 1.000 15.41437 ? 274 SER   A N   1 
ATOM   1470 C  CA  . SER   A 1 274 ? -22.70025 5.71467   37.27286 1.000 20.37372 ? 274 SER   A CA  1 
ATOM   1471 C  C   . SER   A 1 274 ? -21.46979 6.27919   37.97087 1.000 19.83530 ? 274 SER   A C   1 
ATOM   1472 O  O   . SER   A 1 274 ? -21.59990 7.23696   38.74040 1.000 22.50089 ? 274 SER   A O   1 
ATOM   1473 C  CB  . SER   A 1 274 ? -23.62880 5.05585   38.29703 1.000 19.12298 ? 274 SER   A CB  1 
ATOM   1474 O  OG  . SER   A 1 274 ? -22.97018 4.01915   39.00101 1.000 27.67643 ? 274 SER   A OG  1 
ATOM   1475 N  N   . LYS   A 1 275 ? -20.28929 5.71409   37.72156 1.000 18.36996 ? 275 LYS   A N   1 
ATOM   1476 C  CA  . LYS   A 1 275 ? -19.02928 6.22950   38.23613 1.000 17.79593 ? 275 LYS   A CA  1 
ATOM   1477 C  C   . LYS   A 1 275 ? -18.24716 7.00812   37.18506 1.000 17.78038 ? 275 LYS   A C   1 
ATOM   1478 O  O   . LYS   A 1 275 ? -17.11464 7.42081   37.45142 1.000 16.99203 ? 275 LYS   A O   1 
ATOM   1479 C  CB  . LYS   A 1 275 ? -18.17232 5.08107   38.77242 1.000 16.15946 ? 275 LYS   A CB  1 
ATOM   1480 C  CG  . LYS   A 1 275 ? -18.75858 4.37733   39.98084 1.000 19.12221 ? 275 LYS   A CG  1 
ATOM   1481 C  CD  . LYS   A 1 275 ? -18.15175 2.99875   40.15855 1.000 25.99154 ? 275 LYS   A CD  1 
ATOM   1482 C  CE  . LYS   A 1 275 ? -18.86875 2.22574   41.25215 1.000 26.58317 ? 275 LYS   A CE  1 
ATOM   1483 N  NZ  . LYS   A 1 275 ? -18.57865 0.76593   41.18947 1.000 22.14569 ? 275 LYS   A NZ  1 
ATOM   1484 N  N   . HIS   A 1 276 ? -18.82901 7.21854   36.00125 1.000 16.82360 ? 276 HIS   A N   1 
ATOM   1485 C  CA  . HIS   A 1 276 ? -18.09119 7.82727   34.89716 1.000 17.05916 ? 276 HIS   A CA  1 
ATOM   1486 C  C   . HIS   A 1 276 ? -17.69224 9.26590   35.21149 1.000 18.45177 ? 276 HIS   A C   1 
ATOM   1487 O  O   . HIS   A 1 276 ? -16.55147 9.66937   34.96176 1.000 16.82833 ? 276 HIS   A O   1 
ATOM   1488 C  CB  . HIS   A 1 276 ? -18.92370 7.76493   33.61581 1.000 17.15579 ? 276 HIS   A CB  1 
ATOM   1489 C  CG  . HIS   A 1 276 ? -18.48198 8.73080   32.55993 1.000 19.06394 ? 276 HIS   A CG  1 
ATOM   1490 N  ND1 . HIS   A 1 276 ? -17.43260 8.47499   31.70416 1.000 20.30231 ? 276 HIS   A ND1 1 
ATOM   1491 C  CD2 . HIS   A 1 276 ? -18.95008 9.95487   32.22212 1.000 15.60235 ? 276 HIS   A CD2 1 
ATOM   1492 C  CE1 . HIS   A 1 276 ? -17.27356 9.49963   30.88520 1.000 16.04810 ? 276 HIS   A CE1 1 
ATOM   1493 N  NE2 . HIS   A 1 276 ? -18.18116 10.41219  31.17981 1.000 18.10285 ? 276 HIS   A NE2 1 
ATOM   1494 N  N   . MET   A 1 277 ? -18.62191 10.05951  35.75055 1.000 21.55343 ? 277 MET   A N   1 
ATOM   1495 C  CA  . MET   A 1 277 ? -18.33299 11.46527  36.03112 1.000 21.06921 ? 277 MET   A CA  1 
ATOM   1496 C  C   . MET   A 1 277 ? -17.13605 11.61104  36.96354 1.000 19.26583 ? 277 MET   A C   1 
ATOM   1497 O  O   . MET   A 1 277 ? -16.23180 12.41721  36.70779 1.000 20.22577 ? 277 MET   A O   1 
ATOM   1498 C  CB  . MET   A 1 277 ? -19.55930 12.14291  36.64687 1.000 21.55467 ? 277 MET   A CB  1 
ATOM   1499 C  CG  . MET   A 1 277 ? -20.72368 12.38150  35.68280 1.000 26.80369 ? 277 MET   A CG  1 
ATOM   1500 S  SD  . MET   A 1 277 ? -20.26748 12.33181  33.93949 1.000 57.48689 ? 277 MET   A SD  1 
ATOM   1501 C  CE  . MET   A 1 277 ? -19.56668 13.96724  33.72946 1.000 29.58084 ? 277 MET   A CE  1 
ATOM   1502 N  N   . ASN   A 1 278 ? -17.10903 10.83185  38.05117 1.000 20.21380 ? 278 ASN   A N   1 
ATOM   1503 C  CA  . ASN   A 1 278 ? -16.00305 10.92991  38.99801 1.000 22.67119 ? 278 ASN   A CA  1 
ATOM   1504 C  C   . ASN   A 1 278 ? -14.71726 10.38086  38.39863 1.000 24.07241 ? 278 ASN   A C   1 
ATOM   1505 O  O   . ASN   A 1 278 ? -13.64001 10.95165  38.60549 1.000 21.86299 ? 278 ASN   A O   1 
ATOM   1506 C  CB  . ASN   A 1 278 ? -16.34631 10.19390  40.28902 1.000 27.61396 ? 278 ASN   A CB  1 
ATOM   1507 C  CG  . ASN   A 1 278 ? -17.32623 10.96099  41.15338 1.000 26.08624 ? 278 ASN   A CG  1 
ATOM   1508 O  OD1 . ASN   A 1 278 ? -17.50421 12.16630  40.99030 1.000 30.64684 ? 278 ASN   A OD1 1 
ATOM   1509 N  ND2 . ASN   A 1 278 ? -17.97906 10.25884  42.07323 1.000 30.06941 ? 278 ASN   A ND2 1 
ATOM   1510 N  N   . LEU   A 1 279 ? -14.80875 9.27570   37.65220 1.000 21.36515 ? 279 LEU   A N   1 
ATOM   1511 C  CA  . LEU   A 1 279 ? -13.61883 8.69903   37.03414 1.000 22.91062 ? 279 LEU   A CA  1 
ATOM   1512 C  C   . LEU   A 1 279 ? -13.00749 9.65771   36.01755 1.000 22.02136 ? 279 LEU   A C   1 
ATOM   1513 O  O   . LEU   A 1 279 ? -11.78011 9.78927   35.93330 1.000 18.53396 ? 279 LEU   A O   1 
ATOM   1514 C  CB  . LEU   A 1 279 ? -13.97096 7.36345   36.37904 1.000 20.84003 ? 279 LEU   A CB  1 
ATOM   1515 C  CG  . LEU   A 1 279 ? -12.82866 6.37020   36.17670 1.000 23.35648 ? 279 LEU   A CG  1 
ATOM   1516 C  CD1 . LEU   A 1 279 ? -12.49789 5.65886   37.47920 1.000 15.74520 ? 279 LEU   A CD1 1 
ATOM   1517 C  CD2 . LEU   A 1 279 ? -13.17446 5.36711   35.08469 1.000 29.37749 ? 279 LEU   A CD2 1 
ATOM   1518 N  N   . LEU   A 1 280 ? -13.84911 10.34046  35.23864 1.000 18.31283 ? 280 LEU   A N   1 
ATOM   1519 C  CA  . LEU   A 1 280 ? -13.34043 11.31618  34.28014 1.000 17.91945 ? 280 LEU   A CA  1 
ATOM   1520 C  C   . LEU   A 1 280 ? -12.77212 12.53951  34.98774 1.000 22.75292 ? 280 LEU   A C   1 
ATOM   1521 O  O   . LEU   A 1 280 ? -11.75530 13.09512  34.55576 1.000 19.32355 ? 280 LEU   A O   1 
ATOM   1522 C  CB  . LEU   A 1 280 ? -14.44561 11.72466  33.30542 1.000 17.69611 ? 280 LEU   A CB  1 
ATOM   1523 C  CG  . LEU   A 1 280 ? -14.08224 12.80439  32.28245 1.000 20.99733 ? 280 LEU   A CG  1 
ATOM   1524 C  CD1 . LEU   A 1 280 ? -12.87688 12.38410  31.45371 1.000 19.10582 ? 280 LEU   A CD1 1 
ATOM   1525 C  CD2 . LEU   A 1 280 ? -15.26938 13.11718  31.38554 1.000 17.82165 ? 280 LEU   A CD2 1 
ATOM   1526 N  N   . ALA   A 1 281 ? -13.41907 12.97753  36.07170 1.000 22.43826 ? 281 ALA   A N   1 
ATOM   1527 C  CA  . ALA   A 1 281 ? -12.88971 14.09456  36.84708 1.000 25.46507 ? 281 ALA   A CA  1 
ATOM   1528 C  C   . ALA   A 1 281 ? -11.49269 13.78526  37.36620 1.000 22.44524 ? 281 ALA   A C   1 
ATOM   1529 O  O   . ALA   A 1 281 ? -10.60086 14.64087  37.32495 1.000 24.90495 ? 281 ALA   A O   1 
ATOM   1530 C  CB  . ALA   A 1 281 ? -13.83166 14.42416  38.00463 1.000 24.15313 ? 281 ALA   A CB  1 
ATOM   1531 N  N   . ASP   A 1 282 ? -11.28201 12.55972  37.84848 1.000 25.23827 ? 282 ASP   A N   1 
ATOM   1532 C  CA  . ASP   A 1 282 ? -9.96359  12.16840  38.33237 1.000 21.91851 ? 282 ASP   A CA  1 
ATOM   1533 C  C   . ASP   A 1 282 ? -8.96376  12.05412  37.18738 1.000 25.31225 ? 282 ASP   A C   1 
ATOM   1534 O  O   . ASP   A 1 282 ? -7.79268  12.42213  37.34092 1.000 19.40353 ? 282 ASP   A O   1 
ATOM   1535 C  CB  . ASP   A 1 282 ? -10.06593 10.85186  39.10156 1.000 28.02763 ? 282 ASP   A CB  1 
ATOM   1536 C  CG  . ASP   A 1 282 ? -10.54955 11.04360  40.52394 1.000 29.24681 ? 282 ASP   A CG  1 
ATOM   1537 O  OD1 . ASP   A 1 282 ? -10.99066 12.16342  40.85718 1.000 26.90889 ? 282 ASP   A OD1 1 
ATOM   1538 O  OD2 . ASP   A 1 282 ? -10.48861 10.07368  41.30871 1.000 34.23059 ? 282 ASP   A OD2 1 
ATOM   1539 N  N   . LEU   A 1 283 ? -9.40355  11.54430  36.03309 1.000 17.51568 ? 283 LEU   A N   1 
ATOM   1540 C  CA  . LEU   A 1 283 ? -8.51170  11.46022  34.88044 1.000 20.21665 ? 283 LEU   A CA  1 
ATOM   1541 C  C   . LEU   A 1 283 ? -8.08287  12.84628  34.41701 1.000 22.36877 ? 283 LEU   A C   1 
ATOM   1542 O  O   . LEU   A 1 283 ? -6.91804  13.05569  34.05755 1.000 19.80744 ? 283 LEU   A O   1 
ATOM   1543 C  CB  . LEU   A 1 283 ? -9.18857  10.70170  33.73887 1.000 17.12475 ? 283 LEU   A CB  1 
ATOM   1544 C  CG  . LEU   A 1 283 ? -8.29313  10.38771  32.53763 1.000 21.50186 ? 283 LEU   A CG  1 
ATOM   1545 C  CD1 . LEU   A 1 283 ? -7.21022  9.39065   32.92244 1.000 17.86722 ? 283 LEU   A CD1 1 
ATOM   1546 C  CD2 . LEU   A 1 283 ? -9.11089  9.87365   31.35988 1.000 21.01338 ? 283 LEU   A CD2 1 
ATOM   1547 N  N   . LYS   A 1 284 ? -9.01412  13.80413  34.41313 1.000 21.05040 ? 284 LYS   A N   1 
ATOM   1548 C  CA  . LYS   A 1 284 ? -8.66654  15.18275  34.08079 1.000 21.86824 ? 284 LYS   A CA  1 
ATOM   1549 C  C   . LYS   A 1 284 ? -7.60203  15.72153  35.02660 1.000 18.32570 ? 284 LYS   A C   1 
ATOM   1550 O  O   . LYS   A 1 284 ? -6.59754  16.29529  34.58863 1.000 18.38790 ? 284 LYS   A O   1 
ATOM   1551 C  CB  . LYS   A 1 284 ? -9.91189  16.06729  34.12843 1.000 19.88728 ? 284 LYS   A CB  1 
ATOM   1552 C  CG  . LYS   A 1 284 ? -10.81390 15.96154  32.91739 1.000 28.12293 ? 284 LYS   A CG  1 
ATOM   1553 C  CD  . LYS   A 1 284 ? -11.77622 17.13653  32.87586 1.000 29.63071 ? 284 LYS   A CD  1 
ATOM   1554 C  CE  . LYS   A 1 284 ? -12.40523 17.29337  31.50299 1.000 32.84299 ? 284 LYS   A CE  1 
ATOM   1555 N  NZ  . LYS   A 1 284 ? -13.81504 16.81951  31.47608 1.000 41.42189 ? 284 LYS   A NZ  1 
ATOM   1556 N  N   . THR   A 1 285 ? -7.81508  15.55073  36.33495 1.000 25.26783 ? 285 THR   A N   1 
ATOM   1557 C  CA  . THR   A 1 285 ? -6.83502  15.99400  37.32155 1.000 23.39617 ? 285 THR   A CA  1 
ATOM   1558 C  C   . THR   A 1 285 ? -5.45862  15.40668  37.03770 1.000 24.23393 ? 285 THR   A C   1 
ATOM   1559 O  O   . THR   A 1 285 ? -4.44706  16.11561  37.10051 1.000 24.65851 ? 285 THR   A O   1 
ATOM   1560 C  CB  . THR   A 1 285 ? -7.29780  15.61056  38.72931 1.000 20.02146 ? 285 THR   A CB  1 
ATOM   1561 O  OG1 . THR   A 1 285 ? -8.51188  16.30466  39.04408 1.000 17.99657 ? 285 THR   A OG1 1 
ATOM   1562 C  CG2 . THR   A 1 285 ? -6.23646  15.96707  39.75897 1.000 20.89720 ? 285 THR   A CG2 1 
ATOM   1563 N  N   . MET   A 1 286 ? -5.40222  14.11385  36.70581 1.000 23.08723 ? 286 MET   A N   1 
ATOM   1564 C  CA  . MET   A 1 286 ? -4.11825  13.48716  36.40950 1.000 22.67707 ? 286 MET   A CA  1 
ATOM   1565 C  C   . MET   A 1 286 ? -3.46811  14.10968  35.18128 1.000 23.52694 ? 286 MET   A C   1 
ATOM   1566 O  O   . MET   A 1 286 ? -2.25759  14.35385  35.17206 1.000 29.23073 ? 286 MET   A O   1 
ATOM   1567 C  CB  . MET   A 1 286 ? -4.28945  11.98112  36.21324 1.000 23.64388 ? 286 MET   A CB  1 
ATOM   1568 C  CG  . MET   A 1 286 ? -3.04495  11.30419  35.65277 1.000 22.94064 ? 286 MET   A CG  1 
ATOM   1569 S  SD  . MET   A 1 286 ? -3.15747  9.50901   35.56431 1.000 27.78265 ? 286 MET   A SD  1 
ATOM   1570 C  CE  . MET   A 1 286 ? -3.48449  9.10162   37.27602 1.000 21.91843 ? 286 MET   A CE  1 
ATOM   1571 N  N   . VAL   A 1 287 ? -4.25403  14.37396  34.13439 1.000 24.21635 ? 287 VAL   A N   1 
ATOM   1572 C  CA  . VAL   A 1 287 ? -3.70181  14.98949  32.92912 1.000 21.59402 ? 287 VAL   A CA  1 
ATOM   1573 C  C   . VAL   A 1 287 ? -3.14917  16.37428  33.24252 1.000 23.77477 ? 287 VAL   A C   1 
ATOM   1574 O  O   . VAL   A 1 287 ? -2.05625  16.74141  32.79303 1.000 24.60104 ? 287 VAL   A O   1 
ATOM   1575 C  CB  . VAL   A 1 287 ? -4.76805  15.04469  31.81905 1.000 26.23774 ? 287 VAL   A CB  1 
ATOM   1576 C  CG1 . VAL   A 1 287 ? -4.28254  15.89861  30.65644 1.000 23.10314 ? 287 VAL   A CG1 1 
ATOM   1577 C  CG2 . VAL   A 1 287 ? -5.11481  13.64255  31.34622 1.000 23.02696 ? 287 VAL   A CG2 1 
ATOM   1578 N  N   . GLU   A 1 288 ? -3.89265  17.16003  34.02461 1.000 23.02590 ? 288 GLU   A N   1 
ATOM   1579 C  CA  . GLU   A 1 288 ? -3.45139  18.50439  34.38236 1.000 30.29862 ? 288 GLU   A CA  1 
ATOM   1580 C  C   . GLU   A 1 288 ? -2.14523  18.48309  35.16851 1.000 28.70984 ? 288 GLU   A C   1 
ATOM   1581 O  O   . GLU   A 1 288 ? -1.34998  19.42618  35.07866 1.000 29.59570 ? 288 GLU   A O   1 
ATOM   1582 C  CB  . GLU   A 1 288 ? -4.55034  19.20124  35.18781 1.000 27.44596 ? 288 GLU   A CB  1 
ATOM   1583 C  CG  . GLU   A 1 288 ? -4.23266  20.61894  35.63761 1.000 34.05263 ? 288 GLU   A CG  1 
ATOM   1584 C  CD  . GLU   A 1 288 ? -4.09358  21.58824  34.48001 1.000 37.56351 ? 288 GLU   A CD  1 
ATOM   1585 O  OE1 . GLU   A 1 288 ? -4.67356  21.32868  33.40773 1.000 44.20133 ? 288 GLU   A OE1 1 
ATOM   1586 O  OE2 . GLU   A 1 288 ? -3.40136  22.61394  34.63773 1.000 37.46652 ? 288 GLU   A OE2 1 
ATOM   1587 N  N   . THR   A 1 289 ? -1.90175  17.41750  35.93461 1.000 25.26500 ? 289 THR   A N   1 
ATOM   1588 C  CA  . THR   A 1 289 ? -0.73126  17.31757  36.79955 1.000 25.48362 ? 289 THR   A CA  1 
ATOM   1589 C  C   . THR   A 1 289 ? 0.19354   16.17408  36.39563 1.000 28.05701 ? 289 THR   A C   1 
ATOM   1590 O  O   . THR   A 1 289 ? 0.97158   15.69323  37.22623 1.000 24.98994 ? 289 THR   A O   1 
ATOM   1591 C  CB  . THR   A 1 289 ? -1.16049  17.13729  38.25721 1.000 25.18360 ? 289 THR   A CB  1 
ATOM   1592 O  OG1 . THR   A 1 289 ? -1.82352  15.87496  38.40529 1.000 26.50778 ? 289 THR   A OG1 1 
ATOM   1593 C  CG2 . THR   A 1 289 ? -2.10866  18.24741  38.67650 1.000 18.47869 ? 289 THR   A CG2 1 
ATOM   1594 N  N   . LYS   A 1 290 ? 0.13882   15.73459  35.14113 1.000 27.08844 ? 290 LYS   A N   1 
ATOM   1595 C  CA  . LYS   A 1 290 ? 0.81033   14.49882  34.76711 1.000 32.90990 ? 290 LYS   A CA  1 
ATOM   1596 C  C   . LYS   A 1 290 ? 2.32405   14.67508  34.72934 1.000 33.49834 ? 290 LYS   A C   1 
ATOM   1597 O  O   . LYS   A 1 290 ? 2.84712   15.76974  34.50187 1.000 29.71571 ? 290 LYS   A O   1 
ATOM   1598 C  CB  . LYS   A 1 290 ? 0.30093   13.99301  33.41482 1.000 32.18099 ? 290 LYS   A CB  1 
ATOM   1599 C  CG  . LYS   A 1 290 ? 1.00330   14.54576  32.18798 1.000 34.38875 ? 290 LYS   A CG  1 
ATOM   1600 C  CD  . LYS   A 1 290 ? 0.44472   13.88249  30.93581 1.000 35.09828 ? 290 LYS   A CD  1 
ATOM   1601 C  CE  . LYS   A 1 290 ? 1.29242   14.16338  29.70772 1.000 39.45801 ? 290 LYS   A CE  1 
ATOM   1602 N  NZ  . LYS   A 1 290 ? 0.85631   13.33114  28.54934 1.000 37.91663 ? 290 LYS   A NZ  1 
ATOM   1603 N  N   . LYS   A 1 291 ? 3.02435   13.57148  34.97386 1.000 38.88992 ? 291 LYS   A N   1 
ATOM   1604 C  CA  . LYS   A 1 291 ? 4.47675   13.52200  34.97841 1.000 34.75597 ? 291 LYS   A CA  1 
ATOM   1605 C  C   . LYS   A 1 291 ? 4.94127   12.47170  33.98189 1.000 38.03081 ? 291 LYS   A C   1 
ATOM   1606 O  O   . LYS   A 1 291 ? 4.29333   11.43385  33.81165 1.000 28.93611 ? 291 LYS   A O   1 
ATOM   1607 C  CB  . LYS   A 1 291 ? 5.01459   13.19959  36.37735 1.000 34.84112 ? 291 LYS   A CB  1 
ATOM   1608 C  CG  . LYS   A 1 291 ? 4.38702   14.03017  37.48211 1.000 37.97103 ? 291 LYS   A CG  1 
ATOM   1609 C  CD  . LYS   A 1 291 ? 4.81075   15.48256  37.38003 1.000 35.26211 ? 291 LYS   A CD  1 
ATOM   1610 C  CE  . LYS   A 1 291 ? 6.16474   15.71145  38.02346 1.000 45.46245 ? 291 LYS   A CE  1 
ATOM   1611 N  NZ  . LYS   A 1 291 ? 6.00873   16.11634  39.44640 1.000 32.73188 ? 291 LYS   A NZ  1 
ATOM   1612 N  N   . VAL   A 1 292 ? 6.05378   12.75159  33.31209 1.000 39.00024 ? 292 VAL   A N   1 
ATOM   1613 C  CA  . VAL   A 1 292 ? 6.64479   11.82282  32.36046 1.000 37.94753 ? 292 VAL   A CA  1 
ATOM   1614 C  C   . VAL   A 1 292 ? 8.08774   11.57017  32.76796 1.000 37.02218 ? 292 VAL   A C   1 
ATOM   1615 O  O   . VAL   A 1 292 ? 8.72492   12.40498  33.41757 1.000 42.71017 ? 292 VAL   A O   1 
ATOM   1616 C  CB  . VAL   A 1 292 ? 6.56354   12.34991  30.91009 1.000 41.02445 ? 292 VAL   A CB  1 
ATOM   1617 C  CG1 . VAL   A 1 292 ? 5.11078   12.48956  30.48082 1.000 35.27052 ? 292 VAL   A CG1 1 
ATOM   1618 C  CG2 . VAL   A 1 292 ? 7.28553   13.67840  30.78908 1.000 47.59462 ? 292 VAL   A CG2 1 
ATOM   1619 N  N   . THR   A 1 293 ? 8.59844   10.40118  32.39449 1.000 40.44626 ? 293 THR   A N   1 
ATOM   1620 C  CA  . THR   A 1 293 ? 9.95779   10.02828  32.74887 1.000 45.08628 ? 293 THR   A CA  1 
ATOM   1621 C  C   . THR   A 1 293 ? 10.94629  10.61600  31.74449 1.000 46.23078 ? 293 THR   A C   1 
ATOM   1622 O  O   . THR   A 1 293 ? 10.57322  11.28701  30.77735 1.000 42.34010 ? 293 THR   A O   1 
ATOM   1623 C  CB  . THR   A 1 293 ? 10.09662  8.50941   32.81750 1.000 39.33093 ? 293 THR   A CB  1 
ATOM   1624 O  OG1 . THR   A 1 293 ? 9.96895   7.95695   31.50105 1.000 39.47375 ? 293 THR   A OG1 1 
ATOM   1625 C  CG2 . THR   A 1 293 ? 9.02327   7.91784   33.71684 1.000 40.79582 ? 293 THR   A CG2 1 
ATOM   1626 N  N   . SER   A 1 294 ? 12.23460  10.35616  31.98124 1.000 49.00487 ? 294 SER   A N   1 
ATOM   1627 C  CA  . SER   A 1 294 ? 13.26335  10.81764  31.05619 1.000 47.44529 ? 294 SER   A CA  1 
ATOM   1628 C  C   . SER   A 1 294 ? 13.13694  10.14188  29.69801 1.000 45.61342 ? 294 SER   A C   1 
ATOM   1629 O  O   . SER   A 1 294 ? 13.54790  10.71149  28.68046 1.000 52.46795 ? 294 SER   A O   1 
ATOM   1630 C  CB  . SER   A 1 294 ? 14.64938  10.57177  31.65036 1.000 46.04783 ? 294 SER   A CB  1 
ATOM   1631 O  OG  . SER   A 1 294 ? 14.81564  9.20989   32.00249 1.000 42.19509 ? 294 SER   A OG  1 
ATOM   1632 N  N   . SER   A 1 295 ? 12.57345  8.93571   29.65780 1.000 45.04159 ? 295 SER   A N   1 
ATOM   1633 C  CA  . SER   A 1 295 ? 12.28763  8.27344   28.39281 1.000 46.97450 ? 295 SER   A CA  1 
ATOM   1634 C  C   . SER   A 1 295 ? 11.02623  8.80681   27.72408 1.000 45.61830 ? 295 SER   A C   1 
ATOM   1635 O  O   . SER   A 1 295 ? 10.62781  8.27732   26.68081 1.000 50.61463 ? 295 SER   A O   1 
ATOM   1636 C  CB  . SER   A 1 295 ? 12.16443  6.76039   28.60506 1.000 46.22985 ? 295 SER   A CB  1 
ATOM   1637 O  OG  . SER   A 1 295 ? 10.99969  6.43704   29.34401 1.000 48.15405 ? 295 SER   A OG  1 
ATOM   1638 N  N   . GLY   A 1 296 ? 10.39933  9.83902   28.29163 1.000 43.10702 ? 296 GLY   A N   1 
ATOM   1639 C  CA  . GLY   A 1 296 ? 9.19259   10.42478  27.74663 1.000 45.69919 ? 296 GLY   A CA  1 
ATOM   1640 C  C   . GLY   A 1 296 ? 7.91389   9.70210   28.10182 1.000 46.66810 ? 296 GLY   A C   1 
ATOM   1641 O  O   . GLY   A 1 296 ? 6.84430   10.09202  27.61628 1.000 44.42029 ? 296 GLY   A O   1 
ATOM   1642 N  N   . VAL   A 1 297 ? 7.98568   8.68958   28.94629 1.000 43.19690 ? 297 VAL   A N   1 
ATOM   1643 C  CA  . VAL   A 1 297 ? 6.88228   7.77952   29.21516 1.000 40.40972 ? 297 VAL   A CA  1 
ATOM   1644 C  C   . VAL   A 1 297 ? 6.19082   8.18224   30.51537 1.000 40.11865 ? 297 VAL   A C   1 
ATOM   1645 O  O   . VAL   A 1 297 ? 6.80001   8.79055   31.40179 1.000 37.91432 ? 297 VAL   A O   1 
ATOM   1646 C  CB  . VAL   A 1 297 ? 7.43824   6.33653   29.24059 1.000 44.34407 ? 297 VAL   A CB  1 
ATOM   1647 C  CG1 . VAL   A 1 297 ? 6.53993   5.40923   29.96359 1.000 37.86065 ? 297 VAL   A CG1 1 
ATOM   1648 C  CG2 . VAL   A 1 297 ? 7.65123   5.83426   27.82028 1.000 30.75594 ? 297 VAL   A CG2 1 
ATOM   1649 N  N   . LEU   A 1 298 ? 4.89592   7.86753   30.61633 1.000 35.85625 ? 298 LEU   A N   1 
ATOM   1650 C  CA  . LEU   A 1 298 ? 4.08593   8.27621   31.76102 1.000 33.10929 ? 298 LEU   A CA  1 
ATOM   1651 C  C   . LEU   A 1 298 ? 4.63871   7.71337   33.06822 1.000 33.30296 ? 298 LEU   A C   1 
ATOM   1652 O  O   . LEU   A 1 298 ? 4.98018   6.53028   33.15643 1.000 33.05888 ? 298 LEU   A O   1 
ATOM   1653 C  CB  . LEU   A 1 298 ? 2.64056   7.81297   31.55966 1.000 33.41060 ? 298 LEU   A CB  1 
ATOM   1654 C  CG  . LEU   A 1 298 ? 1.51659   8.58831   32.24913 1.000 36.13742 ? 298 LEU   A CG  1 
ATOM   1655 C  CD1 . LEU   A 1 298 ? 1.35472   9.96168   31.61789 1.000 36.45664 ? 298 LEU   A CD1 1 
ATOM   1656 C  CD2 . LEU   A 1 298 ? 0.21088   7.80972   32.18236 1.000 33.21152 ? 298 LEU   A CD2 1 
ATOM   1657 N  N   . LEU   A 1 299 ? 4.70538   8.56601   34.09124 1.000 29.36040 ? 299 LEU   A N   1 
ATOM   1658 C  CA  . LEU   A 1 299 ? 5.25252   8.20860   35.39633 1.000 29.93212 ? 299 LEU   A CA  1 
ATOM   1659 C  C   . LEU   A 1 299 ? 4.11302   7.93738   36.37351 1.000 30.41467 ? 299 LEU   A C   1 
ATOM   1660 O  O   . LEU   A 1 299 ? 3.32084   8.83678   36.67488 1.000 26.22561 ? 299 LEU   A O   1 
ATOM   1661 C  CB  . LEU   A 1 299 ? 6.15965   9.32190   35.92303 1.000 34.04497 ? 299 LEU   A CB  1 
ATOM   1662 C  CG  . LEU   A 1 299 ? 6.53861   9.31701   37.40788 1.000 33.86372 ? 299 LEU   A CG  1 
ATOM   1663 C  CD1 . LEU   A 1 299 ? 7.24927   8.02924   37.79852 1.000 33.79047 ? 299 LEU   A CD1 1 
ATOM   1664 C  CD2 . LEU   A 1 299 ? 7.39861   10.52875  37.74201 1.000 34.30363 ? 299 LEU   A CD2 1 
ATOM   1665 N  N   . LEU   A 1 300 ? 4.04244   6.70344   36.87377 1.000 27.47017 ? 300 LEU   A N   1 
ATOM   1666 C  CA  . LEU   A 1 300 ? 3.00167   6.27142   37.80821 1.000 26.54792 ? 300 LEU   A CA  1 
ATOM   1667 C  C   . LEU   A 1 300 ? 3.68014   5.50716   38.94289 1.000 31.75029 ? 300 LEU   A C   1 
ATOM   1668 O  O   . LEU   A 1 300 ? 3.99113   4.32130   38.79598 1.000 29.38040 ? 300 LEU   A O   1 
ATOM   1669 C  CB  . LEU   A 1 300 ? 1.95875   5.40887   37.10293 1.000 22.55688 ? 300 LEU   A CB  1 
ATOM   1670 C  CG  . LEU   A 1 300 ? 1.27459   5.99050   35.86342 1.000 29.23048 ? 300 LEU   A CG  1 
ATOM   1671 C  CD1 . LEU   A 1 300 ? 0.38859   4.94493   35.20172 1.000 27.37682 ? 300 LEU   A CD1 1 
ATOM   1672 C  CD2 . LEU   A 1 300 ? 0.46824   7.22632   36.22446 1.000 24.26571 ? 300 LEU   A CD2 1 
ATOM   1673 N  N   . ASP   A 1 301 ? 3.89729   6.17740   40.07838 1.000 29.59719 ? 301 ASP   A N   1 
ATOM   1674 C  CA  . ASP   A 1 301 ? 4.71504   5.63536   41.15904 1.000 25.97984 ? 301 ASP   A CA  1 
ATOM   1675 C  C   . ASP   A 1 301 ? 3.90714   5.25168   42.39670 1.000 29.88746 ? 301 ASP   A C   1 
ATOM   1676 O  O   . ASP   A 1 301 ? 4.47256   5.15247   43.49017 1.000 31.81628 ? 301 ASP   A O   1 
ATOM   1677 C  CB  . ASP   A 1 301 ? 5.81893   6.62687   41.53774 1.000 32.65934 ? 301 ASP   A CB  1 
ATOM   1678 C  CG  . ASP   A 1 301 ? 5.27900   7.98338   41.97686 1.000 31.22706 ? 301 ASP   A CG  1 
ATOM   1679 O  OD1 . ASP   A 1 301 ? 4.11454   8.07388   42.42104 1.000 31.33042 ? 301 ASP   A OD1 1 
ATOM   1680 O  OD2 . ASP   A 1 301 ? 6.03686   8.97093   41.88103 1.000 37.44271 ? 301 ASP   A OD2 1 
ATOM   1681 N  N   . ASN   A 1 302 ? 2.60025   5.04566   42.25708 1.000 27.54834 ? 302 ASN   A N   1 
ATOM   1682 C  CA  . ASN   A 1 302 ? 1.79055   4.57357   43.37148 1.000 26.24157 ? 302 ASN   A CA  1 
ATOM   1683 C  C   . ASN   A 1 302 ? 0.57920   3.84265   42.81621 1.000 27.46622 ? 302 ASN   A C   1 
ATOM   1684 O  O   . ASN   A 1 302 ? 0.14254   4.09480   41.69062 1.000 23.16590 ? 302 ASN   A O   1 
ATOM   1685 C  CB  . ASN   A 1 302 ? 1.35814   5.71930   44.29785 1.000 24.03867 ? 302 ASN   A CB  1 
ATOM   1686 C  CG  . ASN   A 1 302 ? 0.45041   6.72189   43.60952 1.000 26.61134 ? 302 ASN   A CG  1 
ATOM   1687 O  OD1 . ASN   A 1 302 ? -0.74716  6.48450   43.44391 1.000 22.38623 ? 302 ASN   A OD1 1 
ATOM   1688 N  ND2 . ASN   A 1 302 ? 1.01584   7.85673   43.21525 1.000 27.47493 ? 302 ASN   A ND2 1 
ATOM   1689 N  N   . TYR   A 1 303 ? 0.03632   2.93112   43.62860 1.000 24.36884 ? 303 TYR   A N   1 
ATOM   1690 C  CA  . TYR   A 1 303 ? -1.07186  2.09862   43.17080 1.000 22.81407 ? 303 TYR   A CA  1 
ATOM   1691 C  C   . TYR   A 1 303 ? -2.26051  2.94072   42.72482 1.000 24.62691 ? 303 TYR   A C   1 
ATOM   1692 O  O   . TYR   A 1 303 ? -2.89825  2.63499   41.70994 1.000 21.27205 ? 303 TYR   A O   1 
ATOM   1693 C  CB  . TYR   A 1 303 ? -1.49841  1.12948   44.27153 1.000 23.37043 ? 303 TYR   A CB  1 
ATOM   1694 C  CG  . TYR   A 1 303 ? -2.65208  0.25035   43.85584 1.000 21.68472 ? 303 TYR   A CG  1 
ATOM   1695 C  CD1 . TYR   A 1 303 ? -2.46481  -0.78292  42.94835 1.000 22.06374 ? 303 TYR   A CD1 1 
ATOM   1696 C  CD2 . TYR   A 1 303 ? -3.93111  0.46240   44.35494 1.000 20.08777 ? 303 TYR   A CD2 1 
ATOM   1697 C  CE1 . TYR   A 1 303 ? -3.51397  -1.58700  42.55582 1.000 20.80592 ? 303 TYR   A CE1 1 
ATOM   1698 C  CE2 . TYR   A 1 303 ? -4.98893  -0.33739  43.96793 1.000 20.98549 ? 303 TYR   A CE2 1 
ATOM   1699 C  CZ  . TYR   A 1 303 ? -4.77362  -1.36094  43.06776 1.000 20.43666 ? 303 TYR   A CZ  1 
ATOM   1700 O  OH  . TYR   A 1 303 ? -5.81962  -2.16400  42.67620 1.000 18.27879 ? 303 TYR   A OH  1 
ATOM   1701 N  N   . SER   A 1 304 ? -2.56908  4.00774   43.46785 1.000 18.91146 ? 304 SER   A N   1 
ATOM   1702 C  CA  . SER   A 1 304 ? -3.74928  4.81257   43.16449 1.000 19.27136 ? 304 SER   A CA  1 
ATOM   1703 C  C   . SER   A 1 304 ? -3.68167  5.39618   41.75810 1.000 22.67704 ? 304 SER   A C   1 
ATOM   1704 O  O   . SER   A 1 304 ? -4.68691  5.41484   41.03899 1.000 21.12650 ? 304 SER   A O   1 
ATOM   1705 C  CB  . SER   A 1 304 ? -3.90528  5.92522   44.20147 1.000 22.97313 ? 304 SER   A CB  1 
ATOM   1706 O  OG  . SER   A 1 304 ? -5.05352  6.71409   43.93999 1.000 35.99279 ? 304 SER   A OG  1 
ATOM   1707 N  N   . ASP   A 1 305 ? -2.50518  5.87473   41.34558 1.000 21.47477 ? 305 ASP   A N   1 
ATOM   1708 C  CA  . ASP   A 1 305 ? -2.36133  6.40777   39.99399 1.000 20.98369 ? 305 ASP   A CA  1 
ATOM   1709 C  C   . ASP   A 1 305 ? -2.37539  5.29514   38.95407 1.000 20.77326 ? 305 ASP   A C   1 
ATOM   1710 O  O   . ASP   A 1 305 ? -2.97611  5.44558   37.88348 1.000 19.70755 ? 305 ASP   A O   1 
ATOM   1711 C  CB  . ASP   A 1 305 ? -1.07263  7.22161   39.87890 1.000 20.75514 ? 305 ASP   A CB  1 
ATOM   1712 C  CG  . ASP   A 1 305 ? -1.18550  8.58799   40.52241 1.000 22.74509 ? 305 ASP   A CG  1 
ATOM   1713 O  OD1 . ASP   A 1 305 ? -2.31431  8.99410   40.86790 1.000 23.16462 ? 305 ASP   A OD1 1 
ATOM   1714 O  OD2 . ASP   A 1 305 ? -0.14488  9.26074   40.67163 1.000 26.33478 ? 305 ASP   A OD2 1 
ATOM   1715 N  N   . ARG   A 1 306 ? -1.71654  4.17347   39.24936 1.000 16.91977 ? 306 ARG   A N   1 
ATOM   1716 C  CA  . ARG   A 1 306 ? -1.62839  3.08564   38.28091 1.000 22.92235 ? 306 ARG   A CA  1 
ATOM   1717 C  C   . ARG   A 1 306 ? -2.98998  2.44391   38.04874 1.000 17.14277 ? 306 ARG   A C   1 
ATOM   1718 O  O   . ARG   A 1 306 ? -3.39315  2.21750   36.90149 1.000 16.79373 ? 306 ARG   A O   1 
ATOM   1719 C  CB  . ARG   A 1 306 ? -0.61311  2.04720   38.75746 1.000 22.13255 ? 306 ARG   A CB  1 
ATOM   1720 C  CG  . ARG   A 1 306 ? 0.77404   2.62062   38.98528 1.000 23.63227 ? 306 ARG   A CG  1 
ATOM   1721 C  CD  . ARG   A 1 306 ? 1.67375   1.65683   39.73865 1.000 20.18839 ? 306 ARG   A CD  1 
ATOM   1722 N  NE  . ARG   A 1 306 ? 2.10998   0.54113   38.90566 1.000 26.20397 ? 306 ARG   A NE  1 
ATOM   1723 C  CZ  . ARG   A 1 306 ? 3.12863   0.59952   38.05374 1.000 27.17260 ? 306 ARG   A CZ  1 
ATOM   1724 N  NH1 . ARG   A 1 306 ? 3.81768   1.72433   37.91381 1.000 21.83499 ? 306 ARG   A NH1 1 
ATOM   1725 N  NH2 . ARG   A 1 306 ? 3.45691   -0.46659  37.33779 1.000 21.97446 ? 306 ARG   A NH2 1 
ATOM   1726 N  N   . ILE   A 1 307 ? -3.71647  2.14555   39.12845 1.000 15.21747 ? 307 ILE   A N   1 
ATOM   1727 C  CA  . ILE   A 1 307 ? -5.02362  1.51775   38.97378 1.000 17.29851 ? 307 ILE   A CA  1 
ATOM   1728 C  C   . ILE   A 1 307 ? -6.00567  2.48105   38.31983 1.000 16.48294 ? 307 ILE   A C   1 
ATOM   1729 O  O   . ILE   A 1 307 ? -6.90477  2.05575   37.58610 1.000 14.78652 ? 307 ILE   A O   1 
ATOM   1730 C  CB  . ILE   A 1 307 ? -5.53897  1.00123   40.33236 1.000 16.18415 ? 307 ILE   A CB  1 
ATOM   1731 C  CG1 . ILE   A 1 307 ? -6.61838  -0.06146  40.12283 1.000 14.94297 ? 307 ILE   A CG1 1 
ATOM   1732 C  CG2 . ILE   A 1 307 ? -6.06864  2.13916   41.19701 1.000 19.22863 ? 307 ILE   A CG2 1 
ATOM   1733 C  CD1 . ILE   A 1 307 ? -6.11670  -1.30001  39.41173 1.000 16.13173 ? 307 ILE   A CD1 1 
ATOM   1734 N  N   . GLN   A 1 308 ? -5.83801  3.78708   38.54395 1.000 16.22888 ? 308 GLN   A N   1 
ATOM   1735 C  CA  . GLN   A 1 308 ? -6.72811  4.76557   37.92867 1.000 18.28047 ? 308 GLN   A CA  1 
ATOM   1736 C  C   . GLN   A 1 308 ? -6.54944  4.80015   36.41576 1.000 16.80218 ? 308 GLN   A C   1 
ATOM   1737 O  O   . GLN   A 1 308 ? -7.52709  4.94725   35.67255 1.000 15.02685 ? 308 GLN   A O   1 
ATOM   1738 C  CB  . GLN   A 1 308 ? -6.48195  6.14409   38.53957 1.000 19.39306 ? 308 GLN   A CB  1 
ATOM   1739 C  CG  . GLN   A 1 308 ? -6.90285  7.30539   37.66662 1.000 23.37606 ? 308 GLN   A CG  1 
ATOM   1740 C  CD  . GLN   A 1 308 ? -6.82402  8.62822   38.39461 1.000 34.24199 ? 308 GLN   A CD  1 
ATOM   1741 O  OE1 . GLN   A 1 308 ? -7.52779  9.57367   38.05474 1.000 34.29475 ? 308 GLN   A OE1 1 
ATOM   1742 N  NE2 . GLN   A 1 308 ? -5.97001  8.69892   39.40978 1.000 28.65875 ? 308 GLN   A NE2 1 
ATOM   1743 N  N   . VAL   A 1 309 ? -5.31000  4.65924   35.94138 1.000 14.50289 ? 309 VAL   A N   1 
ATOM   1744 C  CA  . VAL   A 1 309 ? -5.06797  4.60395   34.50321 1.000 17.45427 ? 309 VAL   A CA  1 
ATOM   1745 C  C   . VAL   A 1 309 ? -5.65419  3.32832   33.91108 1.000 16.45889 ? 309 VAL   A C   1 
ATOM   1746 O  O   . VAL   A 1 309 ? -6.29516  3.35627   32.85317 1.000 16.70006 ? 309 VAL   A O   1 
ATOM   1747 C  CB  . VAL   A 1 309 ? -3.56142  4.72621   34.21206 1.000 15.56436 ? 309 VAL   A CB  1 
ATOM   1748 C  CG1 . VAL   A 1 309 ? -3.26029  4.33051   32.77526 1.000 15.25189 ? 309 VAL   A CG1 1 
ATOM   1749 C  CG2 . VAL   A 1 309 ? -3.09006  6.14218   34.48178 1.000 20.70628 ? 309 VAL   A CG2 1 
ATOM   1750 N  N   . LEU   A 1 310 ? -5.44751  2.19165   34.58102 1.000 11.09008 ? 310 LEU   A N   1 
ATOM   1751 C  CA  . LEU   A 1 310 ? -6.01827  0.93687   34.10097 1.000 14.30733 ? 310 LEU   A CA  1 
ATOM   1752 C  C   . LEU   A 1 310 ? -7.54073  0.97069   34.14716 1.000 14.41515 ? 310 LEU   A C   1 
ATOM   1753 O  O   . LEU   A 1 310 ? -8.20806  0.41828   33.26415 1.000 11.60202 ? 310 LEU   A O   1 
ATOM   1754 C  CB  . LEU   A 1 310 ? -5.48105  -0.23369  34.92430 1.000 14.32999 ? 310 LEU   A CB  1 
ATOM   1755 C  CG  . LEU   A 1 310 ? -3.97314  -0.48645  34.85456 1.000 13.12032 ? 310 LEU   A CG  1 
ATOM   1756 C  CD1 . LEU   A 1 310 ? -3.56816  -1.57236  35.84065 1.000 20.17328 ? 310 LEU   A CD1 1 
ATOM   1757 C  CD2 . LEU   A 1 310 ? -3.55794  -0.86120  33.44028 1.000 15.64633 ? 310 LEU   A CD2 1 
ATOM   1758 N  N   . GLN   A 1 311 ? -8.10774  1.61326   35.17173 1.000 11.52927 ? 311 GLN   A N   1 
ATOM   1759 C  CA  . GLN   A 1 311 ? -9.55844  1.76139   35.24562 1.000 13.91262 ? 311 GLN   A CA  1 
ATOM   1760 C  C   . GLN   A 1 311 ? -10.09014 2.53932   34.04876 1.000 15.75619 ? 311 GLN   A C   1 
ATOM   1761 O  O   . GLN   A 1 311 ? -11.01638 2.09105   33.36337 1.000 15.17371 ? 311 GLN   A O   1 
ATOM   1762 C  CB  . GLN   A 1 311 ? -9.95338  2.45135   36.55305 1.000 12.88076 ? 311 GLN   A CB  1 
ATOM   1763 C  CG  . GLN   A 1 311 ? -9.93207  1.54674   37.77576 1.000 10.66391 ? 311 GLN   A CG  1 
ATOM   1764 C  CD  . GLN   A 1 311 ? -10.06647 2.32107   39.07303 1.000 16.96808 ? 311 GLN   A CD  1 
ATOM   1765 O  OE1 . GLN   A 1 311 ? -9.56956  3.44103   39.19453 1.000 17.20980 ? 311 GLN   A OE1 1 
ATOM   1766 N  NE2 . GLN   A 1 311 ? -10.74202 1.72728   40.05058 1.000 16.37399 ? 311 GLN   A NE2 1 
ATOM   1767 N  N   . ASN   A 1 312 ? -9.50640  3.70935   33.77613 1.000 15.35852 ? 312 ASN   A N   1 
ATOM   1768 C  CA  . ASN   A 1 312 ? -9.97480  4.52414   32.66037 1.000 14.37013 ? 312 ASN   A CA  1 
ATOM   1769 C  C   . ASN   A 1 312 ? -9.66095  3.88089   31.31598 1.000 14.53429 ? 312 ASN   A C   1 
ATOM   1770 O  O   . ASN   A 1 312 ? -10.40195 4.08656   30.34778 1.000 11.59974 ? 312 ASN   A O   1 
ATOM   1771 C  CB  . ASN   A 1 312 ? -9.36513  5.92421   32.73726 1.000 14.02286 ? 312 ASN   A CB  1 
ATOM   1772 C  CG  . ASN   A 1 312 ? -10.06294 6.80844   33.75443 1.000 18.84438 ? 312 ASN   A CG  1 
ATOM   1773 O  OD1 . ASN   A 1 312 ? -11.14922 7.32863   33.49867 1.000 17.31055 ? 312 ASN   A OD1 1 
ATOM   1774 N  ND2 . ASN   A 1 312 ? -9.44262  6.98002   34.91604 1.000 16.14448 ? 312 ASN   A ND2 1 
ATOM   1775 N  N   . MET   A 1 313 ? -8.57687  3.10598   31.23311 1.000 12.01955 ? 313 MET   A N   1 
ATOM   1776 C  CA  . MET   A 1 313 ? -8.24811  2.42711   29.98324 1.000 13.80747 ? 313 MET   A CA  1 
ATOM   1777 C  C   . MET   A 1 313 ? -9.34022  1.43923   29.59487 1.000 12.76984 ? 313 MET   A C   1 
ATOM   1778 O  O   . MET   A 1 313 ? -9.83800  1.45634   28.46311 1.000 12.27783 ? 313 MET   A O   1 
ATOM   1779 C  CB  . MET   A 1 313 ? -6.90324  1.71240   30.10824 1.000 13.30501 ? 313 MET   A CB  1 
ATOM   1780 C  CG  . MET   A 1 313 ? -6.45034  1.04068   28.82433 1.000 13.26374 ? 313 MET   A CG  1 
ATOM   1781 S  SD  . MET   A 1 313 ? -4.99776  0.00064   29.05145 1.000 18.04990 ? 313 MET   A SD  1 
ATOM   1782 C  CE  . MET   A 1 313 ? -3.80109  1.20854   29.60758 1.000 16.76677 ? 313 MET   A CE  1 
ATOM   1783 N  N   . VAL   A 1 314 ? -9.72313  0.56410   30.52694 1.000 10.36643 ? 314 VAL   A N   1 
ATOM   1784 C  CA  . VAL   A 1 314 ? -10.78295 -0.39988  30.25312 1.000 11.76656 ? 314 VAL   A CA  1 
ATOM   1785 C  C   . VAL   A 1 314 ? -12.12153 0.30815   30.08424 1.000 13.14256 ? 314 VAL   A C   1 
ATOM   1786 O  O   . VAL   A 1 314 ? -12.96129 -0.11544  29.27919 1.000 11.88688 ? 314 VAL   A O   1 
ATOM   1787 C  CB  . VAL   A 1 314 ? -10.82333 -1.45783  31.37108 1.000 13.07346 ? 314 VAL   A CB  1 
ATOM   1788 C  CG1 . VAL   A 1 314 ? -11.98803 -2.41275  31.17187 1.000 11.94404 ? 314 VAL   A CG1 1 
ATOM   1789 C  CG2 . VAL   A 1 314 ? -9.50605  -2.21840  31.41467 1.000 9.06007  ? 314 VAL   A CG2 1 
ATOM   1790 N  N   . HIS   A 1 315 ? -12.33958 1.39582   30.82772 1.000 10.34059 ? 315 HIS   A N   1 
ATOM   1791 C  CA  . HIS   A 1 315 ? -13.52572 2.22109   30.62206 1.000 10.77887 ? 315 HIS   A CA  1 
ATOM   1792 C  C   . HIS   A 1 315 ? -13.55513 2.79257   29.20931 1.000 12.17720 ? 315 HIS   A C   1 
ATOM   1793 O  O   . HIS   A 1 315 ? -14.60363 2.79263   28.55228 1.000 8.12075  ? 315 HIS   A O   1 
ATOM   1794 C  CB  . HIS   A 1 315 ? -13.55534 3.33908   31.66678 1.000 14.91951 ? 315 HIS   A CB  1 
ATOM   1795 C  CG  . HIS   A 1 315 ? -14.78293 4.19412   31.61895 1.000 12.90477 ? 315 HIS   A CG  1 
ATOM   1796 N  ND1 . HIS   A 1 315 ? -16.05616 3.67043   31.55583 1.000 12.99605 ? 315 HIS   A ND1 1 
ATOM   1797 C  CD2 . HIS   A 1 315 ? -14.93096 5.53977   31.65004 1.000 11.56354 ? 315 HIS   A CD2 1 
ATOM   1798 C  CE1 . HIS   A 1 315 ? -16.93506 4.65667   31.53783 1.000 13.75047 ? 315 HIS   A CE1 1 
ATOM   1799 N  NE2 . HIS   A 1 315 ? -16.27814 5.80103   31.59352 1.000 11.81568 ? 315 HIS   A NE2 1 
ATOM   1800 N  N   . CYS   A 1 316 ? -12.40670 3.27424   28.72155 1.000 11.21444 ? 316 CYS   A N   1 
ATOM   1801 C  CA  . CYS   A 1 316 ? -12.32757 3.76869   27.34965 1.000 12.10486 ? 316 CYS   A CA  1 
ATOM   1802 C  C   . CYS   A 1 316 ? -12.58774 2.65425   26.34513 1.000 11.83081 ? 316 CYS   A C   1 
ATOM   1803 O  O   . CYS   A 1 316 ? -13.30758 2.85285   25.35947 1.000 10.35769 ? 316 CYS   A O   1 
ATOM   1804 C  CB  . CYS   A 1 316 ? -10.95983 4.40316   27.09232 1.000 14.10239 ? 316 CYS   A CB  1 
ATOM   1805 S  SG  . CYS   A 1 316 ? -10.73581 6.05224   27.80188 1.000 14.55728 ? 316 CYS   A SG  1 
ATOM   1806 N  N   . ALA   A 1 317 ? -11.99895 1.47712   26.57132 1.000 11.75211 ? 317 ALA   A N   1 
ATOM   1807 C  CA  . ALA   A 1 317 ? -12.25302 0.34345   25.68890 1.000 11.42013 ? 317 ALA   A CA  1 
ATOM   1808 C  C   . ALA   A 1 317 ? -13.72617 -0.04049  25.70386 1.000 8.65684  ? 317 ALA   A C   1 
ATOM   1809 O  O   . ALA   A 1 317 ? -14.28784 -0.42385  24.67085 1.000 12.06850 ? 317 ALA   A O   1 
ATOM   1810 C  CB  . ALA   A 1 317 ? -11.38209 -0.84500  26.09658 1.000 11.68537 ? 317 ALA   A CB  1 
ATOM   1811 N  N   . ASP   A 1 318 ? -14.36993 0.06620   26.86880 1.000 10.22180 ? 318 ASP   A N   1 
ATOM   1812 C  CA  . ASP   A 1 318 ? -15.79269 -0.23651  26.97055 1.000 11.50576 ? 318 ASP   A CA  1 
ATOM   1813 C  C   . ASP   A 1 318 ? -16.63659 0.76279   26.18885 1.000 13.35594 ? 318 ASP   A C   1 
ATOM   1814 O  O   . ASP   A 1 318 ? -17.70652 0.40662   25.68093 1.000 12.29758 ? 318 ASP   A O   1 
ATOM   1815 C  CB  . ASP   A 1 318 ? -16.21050 -0.25590  28.44117 1.000 10.94750 ? 318 ASP   A CB  1 
ATOM   1816 C  CG  . ASP   A 1 318 ? -17.54114 -0.94207  28.66241 1.000 16.38984 ? 318 ASP   A CG  1 
ATOM   1817 O  OD1 . ASP   A 1 318 ? -17.85450 -1.89108  27.91370 1.000 11.04989 ? 318 ASP   A OD1 1 
ATOM   1818 O  OD2 . ASP   A 1 318 ? -18.27192 -0.53316  29.58922 1.000 12.58022 ? 318 ASP   A OD2 1 
ATOM   1819 N  N   . LEU   A 1 319 ? -16.17631 2.00702   26.07978 1.000 9.30984  ? 319 LEU   A N   1 
ATOM   1820 C  CA  . LEU   A 1 319 ? -16.87504 3.05845   25.34890 1.000 11.10663 ? 319 LEU   A CA  1 
ATOM   1821 C  C   . LEU   A 1 319 ? -16.12051 3.44548   24.08008 1.000 14.39433 ? 319 LEU   A C   1 
ATOM   1822 O  O   . LEU   A 1 319 ? -15.98546 4.62619   23.75424 1.000 13.37360 ? 319 LEU   A O   1 
ATOM   1823 C  CB  . LEU   A 1 319 ? -17.08891 4.28140   26.23671 1.000 12.44087 ? 319 LEU   A CB  1 
ATOM   1824 C  CG  . LEU   A 1 319 ? -17.79308 4.01781   27.56900 1.000 20.39345 ? 319 LEU   A CG  1 
ATOM   1825 C  CD1 . LEU   A 1 319 ? -18.06360 5.32217   28.30470 1.000 16.44330 ? 319 LEU   A CD1 1 
ATOM   1826 C  CD2 . LEU   A 1 319 ? -19.08221 3.23758   27.35817 1.000 17.11519 ? 319 LEU   A CD2 1 
ATOM   1827 N  N   . SER   A 1 320 ? -15.62800 2.44965   23.34245 1.000 12.83508 ? 320 SER   A N   1 
ATOM   1828 C  CA  . SER   A 1 320 ? -14.79857 2.69840   22.17169 1.000 15.43479 ? 320 SER   A CA  1 
ATOM   1829 C  C   . SER   A 1 320 ? -15.52509 2.49592   20.84776 1.000 12.38842 ? 320 SER   A C   1 
ATOM   1830 O  O   . SER   A 1 320 ? -14.94589 2.80339   19.80014 1.000 12.39085 ? 320 SER   A O   1 
ATOM   1831 C  CB  . SER   A 1 320 ? -13.55552 1.80018   22.20185 1.000 14.86799 ? 320 SER   A CB  1 
ATOM   1832 O  OG  . SER   A 1 320 ? -13.91390 0.43440   22.09631 1.000 15.53695 ? 320 SER   A OG  1 
ATOM   1833 N  N   . ASN   A 1 321 ? -16.76087 1.98707   20.86248 1.000 16.86651 ? 321 ASN   A N   1 
ATOM   1834 C  CA  . ASN   A 1 321 ? -17.51394 1.79260   19.62185 1.000 12.30709 ? 321 ASN   A CA  1 
ATOM   1835 C  C   . ASN   A 1 321 ? -17.52509 3.02076   18.71802 1.000 15.05693 ? 321 ASN   A C   1 
ATOM   1836 O  O   . ASN   A 1 321 ? -17.25028 2.87097   17.51680 1.000 14.10212 ? 321 ASN   A O   1 
ATOM   1837 C  CB  . ASN   A 1 321 ? -18.95748 1.36104   19.92471 1.000 12.03609 ? 321 ASN   A CB  1 
ATOM   1838 C  CG  . ASN   A 1 321 ? -19.03864 0.05843   20.68888 1.000 15.55478 ? 321 ASN   A CG  1 
ATOM   1839 O  OD1 . ASN   A 1 321 ? -20.03040 -0.20767  21.36780 1.000 12.89641 ? 321 ASN   A OD1 1 
ATOM   1840 N  ND2 . ASN   A 1 321 ? -17.99514 -0.75692  20.59332 1.000 12.99027 ? 321 ASN   A ND2 1 
ATOM   1841 N  N   . PRO   A 1 322 ? -17.82208 4.23676   19.19818 1.000 14.32419 ? 322 PRO   A N   1 
ATOM   1842 C  CA  . PRO   A 1 322 ? -17.85890 5.38899   18.28204 1.000 13.65202 ? 322 PRO   A CA  1 
ATOM   1843 C  C   . PRO   A 1 322 ? -16.48970 5.83590   17.78918 1.000 14.03237 ? 322 PRO   A C   1 
ATOM   1844 O  O   . PRO   A 1 322 ? -16.42717 6.72417   16.92860 1.000 11.44952 ? 322 PRO   A O   1 
ATOM   1845 C  CB  . PRO   A 1 322 ? -18.52935 6.48756   19.12234 1.000 13.56918 ? 322 PRO   A CB  1 
ATOM   1846 C  CG  . PRO   A 1 322 ? -19.19387 5.76993   20.25566 1.000 13.50434 ? 322 PRO   A CG  1 
ATOM   1847 C  CD  . PRO   A 1 322 ? -18.28910 4.61939   20.54276 1.000 13.81190 ? 322 PRO   A CD  1 
ATOM   1848 N  N   . THR   A 1 323 ? -15.40017 5.26389   18.30062 1.000 11.26756 ? 323 THR   A N   1 
ATOM   1849 C  CA  . THR   A 1 323 ? -14.06414 5.57515   17.81069 1.000 13.95540 ? 323 THR   A CA  1 
ATOM   1850 C  C   . THR   A 1 323 ? -13.59379 4.61535   16.72747 1.000 13.30738 ? 323 THR   A C   1 
ATOM   1851 O  O   . THR   A 1 323 ? -12.53365 4.84416   16.13508 1.000 14.79875 ? 323 THR   A O   1 
ATOM   1852 C  CB  . THR   A 1 323 ? -13.05165 5.55675   18.96089 1.000 12.90001 ? 323 THR   A CB  1 
ATOM   1853 O  OG1 . THR   A 1 323 ? -12.70137 4.20187   19.27310 1.000 13.12859 ? 323 THR   A OG1 1 
ATOM   1854 C  CG2 . THR   A 1 323 ? -13.63476 6.22089   20.19673 1.000 13.25963 ? 323 THR   A CG2 1 
ATOM   1855 N  N   . LYS   A 1 324 ? -14.34441 3.55583   16.46328 1.000 14.30305 ? 324 LYS   A N   1 
ATOM   1856 C  CA  . LYS   A 1 324 ? -13.98093 2.54346   15.48748 1.000 12.80959 ? 324 LYS   A CA  1 
ATOM   1857 C  C   . LYS   A 1 324 ? -14.42765 2.96031   14.09425 1.000 13.67790 ? 324 LYS   A C   1 
ATOM   1858 O  O   . LYS   A 1 324 ? -15.26501 3.85631   13.94330 1.000 12.55589 ? 324 LYS   A O   1 
ATOM   1859 C  CB  . LYS   A 1 324 ? -14.61592 1.20676   15.86620 1.000 11.90408 ? 324 LYS   A CB  1 
ATOM   1860 C  CG  . LYS   A 1 324 ? -14.15268 0.66276   17.20745 1.000 13.81307 ? 324 LYS   A CG  1 
ATOM   1861 C  CD  . LYS   A 1 324 ? -12.66683 0.34096   17.18953 1.000 12.72983 ? 324 LYS   A CD  1 
ATOM   1862 C  CE  . LYS   A 1 324 ? -12.18475 -0.10934  18.55920 1.000 13.73421 ? 324 LYS   A CE  1 
ATOM   1863 N  NZ  . LYS   A 1 324 ? -12.78793 -1.40578  18.97416 1.000 11.86211 ? 324 LYS   A NZ  1 
ATOM   1864 N  N   . PRO   A 1 325 ? -13.86272 2.34624   13.05138 1.000 13.17019 ? 325 PRO   A N   1 
ATOM   1865 C  CA  . PRO   A 1 325 ? -14.36518 2.58232   11.69304 1.000 14.30747 ? 325 PRO   A CA  1 
ATOM   1866 C  C   . PRO   A 1 325 ? -15.87970 2.43842   11.62974 1.000 14.50902 ? 325 PRO   A C   1 
ATOM   1867 O  O   . PRO   A 1 325 ? -16.47321 1.60765   12.32120 1.000 16.30073 ? 325 PRO   A O   1 
ATOM   1868 C  CB  . PRO   A 1 325 ? -13.65256 1.50773   10.86847 1.000 16.40056 ? 325 PRO   A CB  1 
ATOM   1869 C  CG  . PRO   A 1 325 ? -12.33856 1.34764   11.56920 1.000 15.58675 ? 325 PRO   A CG  1 
ATOM   1870 C  CD  . PRO   A 1 325 ? -12.62817 1.53846   13.04475 1.000 17.30587 ? 325 PRO   A CD  1 
ATOM   1871 N  N   . LEU   A 1 326 ? -16.49991 3.26389   10.78151 1.000 12.90123 ? 326 LEU   A N   1 
ATOM   1872 C  CA  . LEU   A 1 326 ? -17.94247 3.48116   10.85878 1.000 16.28083 ? 326 LEU   A CA  1 
ATOM   1873 C  C   . LEU   A 1 326 ? -18.73007 2.18831   10.67973 1.000 16.73733 ? 326 LEU   A C   1 
ATOM   1874 O  O   . LEU   A 1 326 ? -19.75672 1.98807   11.33992 1.000 16.32284 ? 326 LEU   A O   1 
ATOM   1875 C  CB  . LEU   A 1 326 ? -18.37102 4.51386   9.81727  1.000 16.73339 ? 326 LEU   A CB  1 
ATOM   1876 C  CG  . LEU   A 1 326 ? -19.86684 4.83249   9.77677  1.000 19.12115 ? 326 LEU   A CG  1 
ATOM   1877 C  CD1 . LEU   A 1 326 ? -20.30182 5.55926   11.04214 1.000 16.38378 ? 326 LEU   A CD1 1 
ATOM   1878 C  CD2 . LEU   A 1 326 ? -20.21178 5.64343   8.53958  1.000 18.08936 ? 326 LEU   A CD2 1 
ATOM   1879 N  N   . GLN   A 1 327 ? -18.27318 1.29781   9.79303  1.000 17.14032 ? 327 GLN   A N   1 
ATOM   1880 C  CA  . GLN   A 1 327 ? -19.03041 0.07314   9.54890  1.000 17.10955 ? 327 GLN   A CA  1 
ATOM   1881 C  C   . GLN   A 1 327 ? -19.07617 -0.81347  10.78733 1.000 16.91758 ? 327 GLN   A C   1 
ATOM   1882 O  O   . GLN   A 1 327 ? -20.01553 -1.60061  10.94929 1.000 21.98734 ? 327 GLN   A O   1 
ATOM   1883 C  CB  . GLN   A 1 327 ? -18.45092 -0.68917  8.35345  1.000 19.98730 ? 327 GLN   A CB  1 
ATOM   1884 C  CG  . GLN   A 1 327 ? -17.29272 -1.62300  8.66822  1.000 15.91226 ? 327 GLN   A CG  1 
ATOM   1885 C  CD  . GLN   A 1 327 ? -15.98917 -0.89270  8.91351  1.000 21.85931 ? 327 GLN   A CD  1 
ATOM   1886 O  OE1 . GLN   A 1 327 ? -15.88320 0.31264   8.68595  1.000 27.09947 ? 327 GLN   A OE1 1 
ATOM   1887 N  NE2 . GLN   A 1 327 ? -14.98203 -1.62560  9.37438  1.000 24.99295 ? 327 GLN   A NE2 1 
ATOM   1888 N  N   . LEU   A 1 328 ? -18.08592 -0.69253  11.67311 1.000 14.25418 ? 328 LEU   A N   1 
ATOM   1889 C  CA  . LEU   A 1 328 ? -18.14635 -1.37192  12.96199 1.000 16.68607 ? 328 LEU   A CA  1 
ATOM   1890 C  C   . LEU   A 1 328 ? -19.04563 -0.61588  13.93324 1.000 16.29296 ? 328 LEU   A C   1 
ATOM   1891 O  O   . LEU   A 1 328 ? -19.89170 -1.21583  14.60561 1.000 15.29555 ? 328 LEU   A O   1 
ATOM   1892 C  CB  . LEU   A 1 328 ? -16.73785 -1.52099  13.54021 1.000 14.01492 ? 328 LEU   A CB  1 
ATOM   1893 C  CG  . LEU   A 1 328 ? -15.75914 -2.34959  12.70784 1.000 22.00437 ? 328 LEU   A CG  1 
ATOM   1894 C  CD1 . LEU   A 1 328 ? -14.36716 -2.32191  13.32033 1.000 16.31306 ? 328 LEU   A CD1 1 
ATOM   1895 C  CD2 . LEU   A 1 328 ? -16.26127 -3.77837  12.57544 1.000 22.99230 ? 328 LEU   A CD2 1 
ATOM   1896 N  N   . TYR   A 1 329 ? -18.87198 0.70681   14.00552 1.000 14.69283 ? 329 TYR   A N   1 
ATOM   1897 C  CA  . TYR   A 1 329 ? -19.66044 1.54854   14.90267 1.000 14.83030 ? 329 TYR   A CA  1 
ATOM   1898 C  C   . TYR   A 1 329 ? -21.15877 1.35582   14.68295 1.000 15.96356 ? 329 TYR   A C   1 
ATOM   1899 O  O   . TYR   A 1 329 ? -21.91976 1.16934   15.63960 1.000 14.89137 ? 329 TYR   A O   1 
ATOM   1900 C  CB  . TYR   A 1 329 ? -19.25188 3.01223   14.69070 1.000 13.71143 ? 329 TYR   A CB  1 
ATOM   1901 C  CG  . TYR   A 1 329 ? -19.96426 4.06491   15.52635 1.000 12.15443 ? 329 TYR   A CG  1 
ATOM   1902 C  CD1 . TYR   A 1 329 ? -20.70440 3.73011   16.65588 1.000 11.25809 ? 329 TYR   A CD1 1 
ATOM   1903 C  CD2 . TYR   A 1 329 ? -19.88751 5.40634   15.17373 1.000 11.57817 ? 329 TYR   A CD2 1 
ATOM   1904 C  CE1 . TYR   A 1 329 ? -21.35027 4.70110   17.40127 1.000 13.14723 ? 329 TYR   A CE1 1 
ATOM   1905 C  CE2 . TYR   A 1 329 ? -20.52365 6.38129   15.91395 1.000 14.64025 ? 329 TYR   A CE2 1 
ATOM   1906 C  CZ  . TYR   A 1 329 ? -21.25489 6.02451   17.02480 1.000 14.16337 ? 329 TYR   A CZ  1 
ATOM   1907 O  OH  . TYR   A 1 329 ? -21.88970 6.99739   17.76106 1.000 16.40591 ? 329 TYR   A OH  1 
ATOM   1908 N  N   . ARG   A 1 330 ? -21.60071 1.39484   13.42377 1.000 13.09007 ? 330 ARG   A N   1 
ATOM   1909 C  CA  . ARG   A 1 330 ? -23.03399 1.34738   13.14365 1.000 16.07770 ? 330 ARG   A CA  1 
ATOM   1910 C  C   . ARG   A 1 330 ? -23.64817 0.02749   13.58951 1.000 15.63077 ? 330 ARG   A C   1 
ATOM   1911 O  O   . ARG   A 1 330 ? -24.79095 -0.00633  14.06103 1.000 16.05679 ? 330 ARG   A O   1 
ATOM   1912 C  CB  . ARG   A 1 330 ? -23.28494 1.57863   11.65634 1.000 16.21025 ? 330 ARG   A CB  1 
ATOM   1913 C  CG  . ARG   A 1 330 ? -23.10189 3.02099   11.23261 1.000 18.32091 ? 330 ARG   A CG  1 
ATOM   1914 C  CD  . ARG   A 1 330 ? -23.58355 3.23424   9.81423  1.000 18.45381 ? 330 ARG   A CD  1 
ATOM   1915 N  NE  . ARG   A 1 330 ? -25.00905 2.95573   9.67803  1.000 19.70550 ? 330 ARG   A NE  1 
ATOM   1916 C  CZ  . ARG   A 1 330 ? -25.66684 2.99445   8.52487  1.000 23.18629 ? 330 ARG   A CZ  1 
ATOM   1917 N  NH1 . ARG   A 1 330 ? -25.02482 3.30075   7.40561  1.000 18.57660 ? 330 ARG   A NH1 1 
ATOM   1918 N  NH2 . ARG   A 1 330 ? -26.96533 2.72731   8.49045  1.000 21.68729 ? 330 ARG   A NH2 1 
ATOM   1919 N  N   . GLN   A 1 331 ? -22.90315 -1.06854  13.45206 1.000 13.55423 ? 331 GLN   A N   1 
ATOM   1920 C  CA  . GLN   A 1 331 ? -23.41072 -2.36470  13.88463 1.000 14.76307 ? 331 GLN   A CA  1 
ATOM   1921 C  C   . GLN   A 1 331 ? -23.47234 -2.45909  15.40574 1.000 14.77130 ? 331 GLN   A C   1 
ATOM   1922 O  O   . GLN   A 1 331 ? -24.36835 -3.11493  15.94761 1.000 11.67603 ? 331 GLN   A O   1 
ATOM   1923 C  CB  . GLN   A 1 331 ? -22.54705 -3.47921  13.29022 1.000 18.69700 ? 331 GLN   A CB  1 
ATOM   1924 C  CG  . GLN   A 1 331 ? -22.53872 -4.80397  14.05370 1.000 27.19240 ? 331 GLN   A CG  1 
ATOM   1925 C  CD  . GLN   A 1 331 ? -23.62576 -5.73690  13.62591 1.000 29.41314 ? 331 GLN   A CD  1 
ATOM   1926 O  OE1 . GLN   A 1 331 ? -24.51164 -5.38558  12.84617 1.000 38.33186 ? 331 GLN   A OE1 1 
ATOM   1927 N  NE2 . GLN   A 1 331 ? -23.54909 -6.96347  14.08735 1.000 22.25684 ? 331 GLN   A NE2 1 
ATOM   1928 N  N   . TRP   A 1 332 ? -22.53915 -1.81194  16.11018 1.000 14.59198 ? 332 TRP   A N   1 
ATOM   1929 C  CA  . TRP   A 1 332 ? -22.66133 -1.69759  17.56152 1.000 12.98513 ? 332 TRP   A CA  1 
ATOM   1930 C  C   . TRP   A 1 332 ? -23.88531 -0.87582  17.94139 1.000 12.05985 ? 332 TRP   A C   1 
ATOM   1931 O  O   . TRP   A 1 332 ? -24.59411 -1.20599  18.89971 1.000 13.45156 ? 332 TRP   A O   1 
ATOM   1932 C  CB  . TRP   A 1 332 ? -21.40127 -1.06886  18.16183 1.000 11.90438 ? 332 TRP   A CB  1 
ATOM   1933 C  CG  . TRP   A 1 332 ? -20.19246 -1.94831  18.13450 1.000 13.32977 ? 332 TRP   A CG  1 
ATOM   1934 C  CD1 . TRP   A 1 332 ? -19.00028 -1.68194  17.52771 1.000 13.12925 ? 332 TRP   A CD1 1 
ATOM   1935 C  CD2 . TRP   A 1 332 ? -20.05145 -3.23587  18.74824 1.000 15.67976 ? 332 TRP   A CD2 1 
ATOM   1936 N  NE1 . TRP   A 1 332 ? -18.12624 -2.72261  17.72362 1.000 12.05784 ? 332 TRP   A NE1 1 
ATOM   1937 C  CE2 . TRP   A 1 332 ? -18.74719 -3.68970  18.46942 1.000 13.06684 ? 332 TRP   A CE2 1 
ATOM   1938 C  CE3 . TRP   A 1 332 ? -20.90126 -4.04922  19.50484 1.000 12.32889 ? 332 TRP   A CE3 1 
ATOM   1939 C  CZ2 . TRP   A 1 332 ? -18.27274 -4.92032  18.91925 1.000 14.85276 ? 332 TRP   A CZ2 1 
ATOM   1940 C  CZ3 . TRP   A 1 332 ? -20.42802 -5.27141  19.95000 1.000 14.60353 ? 332 TRP   A CZ3 1 
ATOM   1941 C  CH2 . TRP   A 1 332 ? -19.12628 -5.69412  19.65613 1.000 13.12737 ? 332 TRP   A CH2 1 
ATOM   1942 N  N   . THR   A 1 333 ? -24.14249 0.20786   17.20502 1.000 13.74185 ? 333 THR   A N   1 
ATOM   1943 C  CA  . THR   A 1 333 ? -25.32326 1.02104   17.47506 1.000 14.84583 ? 333 THR   A CA  1 
ATOM   1944 C  C   . THR   A 1 333 ? -26.60083 0.23097   17.22164 1.000 15.06577 ? 333 THR   A C   1 
ATOM   1945 O  O   . THR   A 1 333 ? -27.55659 0.31715   18.00182 1.000 14.72557 ? 333 THR   A O   1 
ATOM   1946 C  CB  . THR   A 1 333 ? -25.29591 2.29084   16.62308 1.000 13.69052 ? 333 THR   A CB  1 
ATOM   1947 O  OG1 . THR   A 1 333 ? -24.10809 3.03831   16.91363 1.000 13.79510 ? 333 THR   A OG1 1 
ATOM   1948 C  CG2 . THR   A 1 333 ? -26.50991 3.15595   16.91846 1.000 14.08813 ? 333 THR   A CG2 1 
ATOM   1949 N  N   . ASP   A 1 334 ? -26.63438 -0.54642  16.13394 1.000 14.27340 ? 334 ASP   A N   1 
ATOM   1950 C  CA  . ASP   A 1 334 ? -27.76484 -1.43733  15.88797 1.000 14.37708 ? 334 ASP   A CA  1 
ATOM   1951 C  C   . ASP   A 1 334 ? -28.00185 -2.36423  17.07191 1.000 17.08271 ? 334 ASP   A C   1 
ATOM   1952 O  O   . ASP   A 1 334 ? -29.14705 -2.58079  17.48557 1.000 14.51978 ? 334 ASP   A O   1 
ATOM   1953 C  CB  . ASP   A 1 334 ? -27.52642 -2.26507  14.62188 1.000 12.30113 ? 334 ASP   A CB  1 
ATOM   1954 C  CG  . ASP   A 1 334 ? -27.57666 -1.43417  13.35617 1.000 19.97595 ? 334 ASP   A CG  1 
ATOM   1955 O  OD1 . ASP   A 1 334 ? -28.06599 -0.28700  13.41131 1.000 23.12749 ? 334 ASP   A OD1 1 
ATOM   1956 O  OD2 . ASP   A 1 334 ? -27.13348 -1.93629  12.30074 1.000 20.94399 ? 334 ASP   A OD2 1 
ATOM   1957 N  N   . ARG   A 1 335 ? -26.92488 -2.91270  17.63799 1.000 12.84018 ? 335 ARG   A N   1 
ATOM   1958 C  CA  . ARG   A 1 335 ? -27.06481 -3.90741  18.69483 1.000 16.30908 ? 335 ARG   A CA  1 
ATOM   1959 C  C   . ARG   A 1 335 ? -27.46554 -3.28064  20.02248 1.000 16.40947 ? 335 ARG   A C   1 
ATOM   1960 O  O   . ARG   A 1 335 ? -28.28997 -3.84629  20.74852 1.000 16.89046 ? 335 ARG   A O   1 
ATOM   1961 C  CB  . ARG   A 1 335 ? -25.76580 -4.69183  18.85671 1.000 13.32003 ? 335 ARG   A CB  1 
ATOM   1962 C  CG  . ARG   A 1 335 ? -25.49261 -5.65136  17.72299 1.000 12.84823 ? 335 ARG   A CG  1 
ATOM   1963 C  CD  . ARG   A 1 335 ? -24.14331 -6.31745  17.88462 1.000 15.99353 ? 335 ARG   A CD  1 
ATOM   1964 N  NE  . ARG   A 1 335 ? -23.89895 -7.27901  16.81900 1.000 14.86254 ? 335 ARG   A NE  1 
ATOM   1965 C  CZ  . ARG   A 1 335 ? -24.23677 -8.56191  16.86860 1.000 20.42953 ? 335 ARG   A CZ  1 
ATOM   1966 N  NH1 . ARG   A 1 335 ? -24.82891 -9.05548  17.94725 1.000 14.57395 ? 335 ARG   A NH1 1 
ATOM   1967 N  NH2 . ARG   A 1 335 ? -23.97272 -9.35164  15.83959 1.000 13.73054 ? 335 ARG   A NH2 1 
ATOM   1968 N  N   . ILE   A 1 336 ? -26.88911 -2.12771  20.36975 1.000 16.86696 ? 336 ILE   A N   1 
ATOM   1969 C  CA  . ILE   A 1 336 ? -27.26411 -1.50105  21.63278 1.000 16.58189 ? 336 ILE   A CA  1 
ATOM   1970 C  C   . ILE   A 1 336 ? -28.70148 -0.99813  21.57468 1.000 16.37306 ? 336 ILE   A C   1 
ATOM   1971 O  O   . ILE   A 1 336 ? -29.41503 -1.02615  22.58452 1.000 17.95867 ? 336 ILE   A O   1 
ATOM   1972 C  CB  . ILE   A 1 336 ? -26.27726 -0.37598  22.00630 1.000 18.41328 ? 336 ILE   A CB  1 
ATOM   1973 C  CG1 . ILE   A 1 336 ? -26.45738 0.02234   23.47329 1.000 15.64360 ? 336 ILE   A CG1 1 
ATOM   1974 C  CG2 . ILE   A 1 336 ? -26.45217 0.83807   21.10634 1.000 14.48666 ? 336 ILE   A CG2 1 
ATOM   1975 C  CD1 . ILE   A 1 336 ? -26.34404 -1.14074  24.43822 1.000 17.38714 ? 336 ILE   A CD1 1 
ATOM   1976 N  N   . MET   A 1 337 ? -29.16304 -0.55762  20.40050 1.000 21.39373 ? 337 MET   A N   1 
ATOM   1977 C  CA  . MET   A 1 337 ? -30.53152 -0.06307  20.29257 1.000 20.52245 ? 337 MET   A CA  1 
ATOM   1978 C  C   . MET   A 1 337 ? -31.53791 -1.20116  20.39610 1.000 17.83996 ? 337 MET   A C   1 
ATOM   1979 O  O   . MET   A 1 337 ? -32.61194 -1.03459  20.98655 1.000 19.23277 ? 337 MET   A O   1 
ATOM   1980 C  CB  . MET   A 1 337 ? -30.71707 0.70651   18.98463 1.000 19.03787 ? 337 MET   A CB  1 
ATOM   1981 C  CG  . MET   A 1 337 ? -30.07957 2.09052   18.98059 1.000 19.69374 ? 337 MET   A CG  1 
ATOM   1982 S  SD  . MET   A 1 337 ? -30.29047 2.99301   20.53171 1.000 25.77370 ? 337 MET   A SD  1 
ATOM   1983 C  CE  . MET   A 1 337 ? -32.07006 3.17545   20.60282 1.000 24.48287 ? 337 MET   A CE  1 
ATOM   1984 N  N   . GLU   A 1 338 ? -31.21139 -2.36120  19.82180 1.000 19.46165 ? 338 GLU   A N   1 
ATOM   1985 C  CA  . GLU   A 1 338 ? -32.04284 -3.54559  20.00755 1.000 20.59984 ? 338 GLU   A CA  1 
ATOM   1986 C  C   . GLU   A 1 338 ? -32.20763 -3.86022  21.48767 1.000 24.32061 ? 338 GLU   A C   1 
ATOM   1987 O  O   . GLU   A 1 338 ? -33.32417 -4.07203  21.97437 1.000 20.34062 ? 338 GLU   A O   1 
ATOM   1988 C  CB  . GLU   A 1 338 ? -31.42486 -4.73752  19.27396 1.000 21.86601 ? 338 GLU   A CB  1 
ATOM   1989 C  CG  . GLU   A 1 338 ? -32.19506 -6.03716  19.43520 1.000 27.73348 ? 338 GLU   A CG  1 
ATOM   1990 C  CD  . GLU   A 1 338 ? -33.42246 -6.10030  18.55160 1.000 43.01647 ? 338 GLU   A CD  1 
ATOM   1991 O  OE1 . GLU   A 1 338 ? -34.37108 -6.82883  18.90527 1.000 48.30685 ? 338 GLU   A OE1 1 
ATOM   1992 O  OE2 . GLU   A 1 338 ? -33.43357 -5.42643  17.50098 1.000 41.06922 ? 338 GLU   A OE2 1 
ATOM   1993 N  N   . GLU   A 1 339 ? -31.09176 -3.88164  22.21979 1.000 20.46363 ? 339 GLU   A N   1 
ATOM   1994 C  CA  . GLU   A 1 339 ? -31.13000 -4.17704  23.64734 1.000 22.26431 ? 339 GLU   A CA  1 
ATOM   1995 C  C   . GLU   A 1 339 ? -31.95700 -3.14704  24.40614 1.000 21.68471 ? 339 GLU   A C   1 
ATOM   1996 O  O   . GLU   A 1 339 ? -32.75707 -3.50372  25.27933 1.000 28.41068 ? 339 GLU   A O   1 
ATOM   1997 C  CB  . GLU   A 1 339 ? -29.70603 -4.23024  24.19456 1.000 23.87431 ? 339 GLU   A CB  1 
ATOM   1998 C  CG  . GLU   A 1 339 ? -29.40968 -5.42701  25.06638 1.000 20.17900 ? 339 GLU   A CG  1 
ATOM   1999 C  CD  . GLU   A 1 339 ? -27.98189 -5.42330  25.56410 1.000 18.14974 ? 339 GLU   A CD  1 
ATOM   2000 O  OE1 . GLU   A 1 339 ? -27.11332 -5.98039  24.86789 1.000 17.00949 ? 339 GLU   A OE1 1 
ATOM   2001 O  OE2 . GLU   A 1 339 ? -27.72620 -4.85760  26.64690 1.000 18.99227 ? 339 GLU   A OE2 1 
ATOM   2002 N  N   . PHE   A 1 340 ? -31.77810 -1.86319  24.08592 1.000 20.40636 ? 340 PHE   A N   1 
ATOM   2003 C  CA  . PHE   A 1 340 ? -32.55619 -0.81719  24.74349 1.000 26.12379 ? 340 PHE   A CA  1 
ATOM   2004 C  C   . PHE   A 1 340 ? -34.04335 -0.98316  24.46325 1.000 28.90643 ? 340 PHE   A C   1 
ATOM   2005 O  O   . PHE   A 1 340 ? -34.86967 -0.93977  25.38231 1.000 27.94331 ? 340 PHE   A O   1 
ATOM   2006 C  CB  . PHE   A 1 340 ? -32.08634 0.56385   24.28495 1.000 23.11470 ? 340 PHE   A CB  1 
ATOM   2007 C  CG  . PHE   A 1 340 ? -30.85740 1.06096   24.99055 1.000 27.47468 ? 340 PHE   A CG  1 
ATOM   2008 C  CD1 . PHE   A 1 340 ? -29.98292 0.18287   25.60925 1.000 25.90539 ? 340 PHE   A CD1 1 
ATOM   2009 C  CD2 . PHE   A 1 340 ? -30.58352 2.41694   25.04088 1.000 28.16965 ? 340 PHE   A CD2 1 
ATOM   2010 C  CE1 . PHE   A 1 340 ? -28.85601 0.65005   26.25623 1.000 25.44598 ? 340 PHE   A CE1 1 
ATOM   2011 C  CE2 . PHE   A 1 340 ? -29.46068 2.88820   25.68634 1.000 27.52220 ? 340 PHE   A CE2 1 
ATOM   2012 C  CZ  . PHE   A 1 340 ? -28.59708 2.00411   26.29430 1.000 22.88516 ? 340 PHE   A CZ  1 
ATOM   2013 N  N   . PHE   A 1 341 ? -34.40124 -1.16522  23.18907 1.000 28.63389 ? 341 PHE   A N   1 
ATOM   2014 C  CA  . PHE   A 1 341 ? -35.80567 -1.31430  22.82153 1.000 28.96624 ? 341 PHE   A CA  1 
ATOM   2015 C  C   . PHE   A 1 341 ? -36.43857 -2.50662  23.52365 1.000 23.87950 ? 341 PHE   A C   1 
ATOM   2016 O  O   . PHE   A 1 341 ? -37.58713 -2.43291  23.97658 1.000 27.06524 ? 341 PHE   A O   1 
ATOM   2017 C  CB  . PHE   A 1 341 ? -35.93785 -1.45707  21.30626 1.000 26.10262 ? 341 PHE   A CB  1 
ATOM   2018 C  CG  . PHE   A 1 341 ? -35.64525 -0.19568  20.55367 1.000 27.60104 ? 341 PHE   A CG  1 
ATOM   2019 C  CD1 . PHE   A 1 341 ? -35.72456 1.03402   21.18369 1.000 29.14638 ? 341 PHE   A CD1 1 
ATOM   2020 C  CD2 . PHE   A 1 341 ? -35.29356 -0.23787  19.21577 1.000 28.44738 ? 341 PHE   A CD2 1 
ATOM   2021 C  CE1 . PHE   A 1 341 ? -35.45644 2.19594   20.49448 1.000 32.64714 ? 341 PHE   A CE1 1 
ATOM   2022 C  CE2 . PHE   A 1 341 ? -35.02522 0.92223   18.51989 1.000 32.35769 ? 341 PHE   A CE2 1 
ATOM   2023 C  CZ  . PHE   A 1 341 ? -35.10715 2.14023   19.15914 1.000 31.68524 ? 341 PHE   A CZ  1 
ATOM   2024 N  N   . ARG   A 1 342 ? -35.70254 -3.61393  23.62891 1.000 24.12492 ? 342 ARG   A N   1 
ATOM   2025 C  CA  . ARG   A 1 342 ? -36.24277 -4.79168  24.29564 1.000 28.30611 ? 342 ARG   A CA  1 
ATOM   2026 C  C   . ARG   A 1 342 ? -36.39459 -4.56978  25.79535 1.000 32.39853 ? 342 ARG   A C   1 
ATOM   2027 O  O   . ARG   A 1 342 ? -37.32939 -5.10254  26.40399 1.000 38.26379 ? 342 ARG   A O   1 
ATOM   2028 C  CB  . ARG   A 1 342 ? -35.36088 -6.00303  23.99496 1.000 27.89599 ? 342 ARG   A CB  1 
ATOM   2029 C  CG  . ARG   A 1 342 ? -35.54148 -6.51032  22.57074 1.000 33.21955 ? 342 ARG   A CG  1 
ATOM   2030 C  CD  . ARG   A 1 342 ? -34.45217 -7.48161  22.14371 1.000 38.73119 ? 342 ARG   A CD  1 
ATOM   2031 N  NE  . ARG   A 1 342 ? -34.31223 -8.61664  23.05186 1.000 50.12235 ? 342 ARG   A NE  1 
ATOM   2032 C  CZ  . ARG   A 1 342 ? -35.19804 -9.60124  23.17383 1.000 55.02505 ? 342 ARG   A CZ  1 
ATOM   2033 N  NH1 . ARG   A 1 342 ? -34.97050 -10.59147 24.02583 1.000 45.17685 ? 342 ARG   A NH1 1 
ATOM   2034 N  NH2 . ARG   A 1 342 ? -36.31263 -9.59784  22.45421 1.000 55.23013 ? 342 ARG   A NH2 1 
ATOM   2035 N  N   . GLN   A 1 343 ? -35.50839 -3.78060  26.40675 1.000 28.18166 ? 343 GLN   A N   1 
ATOM   2036 C  CA  . GLN   A 1 343 ? -35.73187 -3.38074  27.79260 1.000 30.53425 ? 343 GLN   A CA  1 
ATOM   2037 C  C   . GLN   A 1 343 ? -36.95522 -2.47948  27.90449 1.000 34.08545 ? 343 GLN   A C   1 
ATOM   2038 O  O   . GLN   A 1 343 ? -37.80662 -2.67706  28.77930 1.000 33.06265 ? 343 GLN   A O   1 
ATOM   2039 C  CB  . GLN   A 1 343 ? -34.49897 -2.67612  28.36128 1.000 23.75936 ? 343 GLN   A CB  1 
ATOM   2040 C  CG  . GLN   A 1 343 ? -34.75504 -2.06194  29.73631 1.000 26.27008 ? 343 GLN   A CG  1 
ATOM   2041 C  CD  . GLN   A 1 343 ? -33.51249 -1.47850  30.38054 1.000 19.87162 ? 343 GLN   A CD  1 
ATOM   2042 O  OE1 . GLN   A 1 343 ? -32.42921 -2.05728  30.30844 1.000 19.37591 ? 343 GLN   A OE1 1 
ATOM   2043 N  NE2 . GLN   A 1 343 ? -33.66724 -0.32652  31.02362 1.000 23.10957 ? 343 GLN   A NE2 1 
ATOM   2044 N  N   . GLY   A 1 344 ? -37.06006 -1.48339  27.01977 1.000 30.47700 ? 344 GLY   A N   1 
ATOM   2045 C  CA  . GLY   A 1 344 ? -38.20637 -0.59031  27.04843 1.000 36.02170 ? 344 GLY   A CA  1 
ATOM   2046 C  C   . GLY   A 1 344 ? -39.52106 -1.29416  26.77917 1.000 39.21326 ? 344 GLY   A C   1 
ATOM   2047 O  O   . GLY   A 1 344 ? -40.56864 -0.87026  27.27536 1.000 40.70304 ? 344 GLY   A O   1 
ATOM   2048 N  N   . ASP   A 1 345 ? -39.49056 -2.36577  25.98316 1.000 33.26426 ? 345 ASP   A N   1 
ATOM   2049 C  CA  . ASP   A 1 345 ? -40.68097 -3.19066  25.80349 1.000 36.40099 ? 345 ASP   A CA  1 
ATOM   2050 C  C   . ASP   A 1 345 ? -41.13967 -3.77372  27.13318 1.000 40.65086 ? 345 ASP   A C   1 
ATOM   2051 O  O   . ASP   A 1 345 ? -42.31792 -3.67872  27.49595 1.000 46.93898 ? 345 ASP   A O   1 
ATOM   2052 C  CB  . ASP   A 1 345 ? -40.39923 -4.30783  24.79775 1.000 35.30512 ? 345 ASP   A CB  1 
ATOM   2053 C  CG  . ASP   A 1 345 ? -40.38743 -3.81536  23.36598 1.000 33.85166 ? 345 ASP   A CG  1 
ATOM   2054 O  OD1 . ASP   A 1 345 ? -40.47854 -2.58798  23.15759 1.000 33.34971 ? 345 ASP   A OD1 1 
ATOM   2055 O  OD2 . ASP   A 1 345 ? -40.28233 -4.65703  22.44902 1.000 30.77167 ? 345 ASP   A OD2 1 
ATOM   2056 N  N   . ARG   A 1 346 ? -40.21132 -4.37607  27.87987 1.000 42.45744 ? 346 ARG   A N   1 
ATOM   2057 C  CA  . ARG   A 1 346 ? -40.55740 -4.96388  29.16863 1.000 40.93484 ? 346 ARG   A CA  1 
ATOM   2058 C  C   . ARG   A 1 346 ? -40.93908 -3.90035  30.19036 1.000 42.11480 ? 346 ARG   A C   1 
ATOM   2059 O  O   . ARG   A 1 346 ? -41.75855 -4.16398  31.07616 1.000 47.59797 ? 346 ARG   A O   1 
ATOM   2060 C  CB  . ARG   A 1 346 ? -39.39414 -5.81388  29.67715 1.000 36.49828 ? 346 ARG   A CB  1 
ATOM   2061 C  CG  . ARG   A 1 346 ? -39.09431 -7.01230  28.78984 1.000 39.19585 ? 346 ARG   A CG  1 
ATOM   2062 C  CD  . ARG   A 1 346 ? -37.67907 -7.52321  28.99022 1.000 36.01190 ? 346 ARG   A CD  1 
ATOM   2063 N  NE  . ARG   A 1 346 ? -37.42674 -7.93722  30.36596 1.000 40.62669 ? 346 ARG   A NE  1 
ATOM   2064 C  CZ  . ARG   A 1 346 ? -36.29340 -8.49484  30.77858 1.000 47.14299 ? 346 ARG   A CZ  1 
ATOM   2065 N  NH1 . ARG   A 1 346 ? -35.30604 -8.70729  29.91880 1.000 38.89997 ? 346 ARG   A NH1 1 
ATOM   2066 N  NH2 . ARG   A 1 346 ? -36.14726 -8.84198  32.04991 1.000 35.11848 ? 346 ARG   A NH2 1 
ATOM   2067 N  N   . GLU   A 1 347 ? -40.36243 -2.70032  30.08823 1.000 34.86093 ? 347 GLU   A N   1 
ATOM   2068 C  CA  . GLU   A 1 347 ? -40.79280 -1.60524  30.95201 1.000 41.97844 ? 347 GLU   A CA  1 
ATOM   2069 C  C   . GLU   A 1 347 ? -42.22990 -1.20317  30.64745 1.000 49.02355 ? 347 GLU   A C   1 
ATOM   2070 O  O   . GLU   A 1 347 ? -43.03372 -0.99911  31.56450 1.000 45.30342 ? 347 GLU   A O   1 
ATOM   2071 C  CB  . GLU   A 1 347 ? -39.86132 -0.40554  30.78834 1.000 37.28526 ? 347 GLU   A CB  1 
ATOM   2072 C  CG  . GLU   A 1 347 ? -38.44463 -0.63389  31.27953 1.000 33.00246 ? 347 GLU   A CG  1 
ATOM   2073 C  CD  . GLU   A 1 347 ? -37.52915 0.53063   30.95589 1.000 36.48599 ? 347 GLU   A CD  1 
ATOM   2074 O  OE1 . GLU   A 1 347 ? -37.83907 1.28628   30.01130 1.000 34.18353 ? 347 GLU   A OE1 1 
ATOM   2075 O  OE2 . GLU   A 1 347 ? -36.50253 0.69435   31.64746 1.000 31.04311 ? 347 GLU   A OE2 1 
ATOM   2076 N  N   . ARG   A 1 348 ? -42.56913 -1.08675  29.36232 1.000 47.72942 ? 348 ARG   A N   1 
ATOM   2077 C  CA  . ARG   A 1 348 ? -43.93112 -0.73589  28.97526 1.000 50.34505 ? 348 ARG   A CA  1 
ATOM   2078 C  C   . ARG   A 1 348 ? -44.90644 -1.85864  29.30396 1.000 48.83792 ? 348 ARG   A C   1 
ATOM   2079 O  O   . ARG   A 1 348 ? -46.02920 -1.60136  29.75277 1.000 54.61567 ? 348 ARG   A O   1 
ATOM   2080 C  CB  . ARG   A 1 348 ? -43.96628 -0.40544  27.48280 1.000 54.02531 ? 348 ARG   A CB  1 
ATOM   2081 C  CG  . ARG   A 1 348 ? -45.30597 -0.60097  26.79644 1.000 56.57899 ? 348 ARG   A CG  1 
ATOM   2082 C  CD  . ARG   A 1 348 ? -45.18379 -0.51189  25.28130 1.000 55.71997 ? 348 ARG   A CD  1 
ATOM   2083 N  NE  . ARG   A 1 348 ? -44.26754 0.51222   24.81799 1.000 51.48082 ? 348 ARG   A NE  1 
ATOM   2084 C  CZ  . ARG   A 1 348 ? -43.13939 0.24519   24.17173 1.000 49.71713 ? 348 ARG   A CZ  1 
ATOM   2085 N  NH1 . ARG   A 1 348 ? -42.76940 -1.00316  23.88902 1.000 46.93457 ? 348 ARG   A NH1 1 
ATOM   2086 N  NH2 . ARG   A 1 348 ? -42.35733 1.24334   23.78588 1.000 48.29457 ? 348 ARG   A NH2 1 
ATOM   2087 N  N   . GLU   A 1 349 ? -44.49590 -3.10949  29.07749 1.000 51.45666 ? 349 GLU   A N   1 
ATOM   2088 C  CA  . GLU   A 1 349 ? -45.34307 -4.25657  29.38990 1.000 47.45639 ? 349 GLU   A CA  1 
ATOM   2089 C  C   . GLU   A 1 349 ? -45.70163 -4.31026  30.87064 1.000 51.63506 ? 349 GLU   A C   1 
ATOM   2090 O  O   . GLU   A 1 349 ? -46.76297 -4.83083  31.23560 1.000 51.67610 ? 349 GLU   A O   1 
ATOM   2091 C  CB  . GLU   A 1 349 ? -44.63172 -5.54290  28.95975 1.000 49.88344 ? 349 GLU   A CB  1 
ATOM   2092 C  CG  . GLU   A 1 349 ? -45.25261 -6.83861  29.45208 1.000 52.59991 ? 349 GLU   A CG  1 
ATOM   2093 C  CD  . GLU   A 1 349 ? -44.33909 -8.03015  29.23877 1.000 62.44425 ? 349 GLU   A CD  1 
ATOM   2094 O  OE1 . GLU   A 1 349 ? -44.80334 -9.17447  29.41745 1.000 53.51849 ? 349 GLU   A OE1 1 
ATOM   2095 O  OE2 . GLU   A 1 349 ? -43.15629 -7.81938  28.89621 1.000 62.70706 ? 349 GLU   A OE2 1 
ATOM   2096 N  N   . ARG   A 1 350 ? -44.84676 -3.76393  31.73385 1.000 50.46142 ? 350 ARG   A N   1 
ATOM   2097 C  CA  . ARG   A 1 350 ? -45.00369 -3.88631  33.17694 1.000 48.34273 ? 350 ARG   A CA  1 
ATOM   2098 C  C   . ARG   A 1 350 ? -45.52486 -2.61271  33.83414 1.000 51.39599 ? 350 ARG   A C   1 
ATOM   2099 O  O   . ARG   A 1 350 ? -45.57199 -2.54007  35.06689 1.000 51.95298 ? 350 ARG   A O   1 
ATOM   2100 C  CB  . ARG   A 1 350 ? -43.67191 -4.29894  33.80621 1.000 40.98415 ? 350 ARG   A CB  1 
ATOM   2101 C  CG  . ARG   A 1 350 ? -43.18938 -5.67781  33.37769 1.000 41.45969 ? 350 ARG   A CG  1 
ATOM   2102 C  CD  . ARG   A 1 350 ? -41.73415 -5.87777  33.75625 1.000 44.86958 ? 350 ARG   A CD  1 
ATOM   2103 N  NE  . ARG   A 1 350 ? -41.47974 -5.42118  35.11628 1.000 45.74006 ? 350 ARG   A NE  1 
ATOM   2104 C  CZ  . ARG   A 1 350 ? -41.20951 -6.22884  36.13435 1.000 41.55410 ? 350 ARG   A CZ  1 
ATOM   2105 N  NH1 . ARG   A 1 350 ? -41.14403 -7.53869  35.94285 1.000 36.93148 ? 350 ARG   A NH1 1 
ATOM   2106 N  NH2 . ARG   A 1 350 ? -41.00025 -5.72617  37.34249 1.000 38.48055 ? 350 ARG   A NH2 1 
ATOM   2107 N  N   . GLY   A 1 351 ? -45.92054 -1.61149  33.04981 1.000 46.59534 ? 351 GLY   A N   1 
ATOM   2108 C  CA  . GLY   A 1 351 ? -46.45899 -0.38266  33.59546 1.000 42.87988 ? 351 GLY   A CA  1 
ATOM   2109 C  C   . GLY   A 1 351 ? -45.43240 0.63727   34.03422 1.000 46.37651 ? 351 GLY   A C   1 
ATOM   2110 O  O   . GLY   A 1 351 ? -45.81594 1.68786   34.56525 1.000 49.84099 ? 351 GLY   A O   1 
ATOM   2111 N  N   . MET   A 1 352 ? -44.14754 0.36939   33.82978 1.000 45.39567 ? 352 MET   A N   1 
ATOM   2112 C  CA  . MET   A 1 352 ? -43.10083 1.29181   34.23621 1.000 46.29816 ? 352 MET   A CA  1 
ATOM   2113 C  C   . MET   A 1 352 ? -42.89703 2.37218   33.18224 1.000 44.61670 ? 352 MET   A C   1 
ATOM   2114 O  O   . MET   A 1 352 ? -43.19549 2.18200   31.99939 1.000 44.87174 ? 352 MET   A O   1 
ATOM   2115 C  CB  . MET   A 1 352 ? -41.78956 0.53898   34.46232 1.000 43.72784 ? 352 MET   A CB  1 
ATOM   2116 C  CG  . MET   A 1 352 ? -41.93991 -0.72346  35.29423 1.000 44.06386 ? 352 MET   A CG  1 
ATOM   2117 S  SD  . MET   A 1 352 ? -40.53112 -1.84000  35.14494 1.000 36.00432 ? 352 MET   A SD  1 
ATOM   2118 C  CE  . MET   A 1 352 ? -39.18464 -0.75954  35.61960 1.000 28.99548 ? 352 MET   A CE  1 
ATOM   2119 N  N   . GLU   A 1 353 ? -42.39308 3.52084   33.62704 1.000 43.14813 ? 353 GLU   A N   1 
ATOM   2120 C  CA  . GLU   A 1 353 ? -41.92872 4.53157   32.68931 1.000 43.78635 ? 353 GLU   A CA  1 
ATOM   2121 C  C   . GLU   A 1 353 ? -40.79490 3.95992   31.85051 1.000 45.51478 ? 353 GLU   A C   1 
ATOM   2122 O  O   . GLU   A 1 353 ? -39.92378 3.24811   32.35758 1.000 41.40592 ? 353 GLU   A O   1 
ATOM   2123 C  CB  . GLU   A 1 353 ? -41.45673 5.78150   33.43651 1.000 44.81223 ? 353 GLU   A CB  1 
ATOM   2124 C  CG  . GLU   A 1 353 ? -40.75847 6.81125   32.55534 1.000 55.59199 ? 353 GLU   A CG  1 
ATOM   2125 C  CD  . GLU   A 1 353 ? -40.29186 8.03082   33.32928 1.000 60.37016 ? 353 GLU   A CD  1 
ATOM   2126 O  OE1 . GLU   A 1 353 ? -39.68448 7.85685   34.40611 1.000 66.58093 ? 353 GLU   A OE1 1 
ATOM   2127 O  OE2 . GLU   A 1 353 ? -40.52685 9.16369   32.85877 1.000 59.81293 ? 353 GLU   A OE2 1 
ATOM   2128 N  N   . ILE   A 1 354 ? -40.81768 4.25338   30.55784 1.000 41.80201 ? 354 ILE   A N   1 
ATOM   2129 C  CA  . ILE   A 1 354 ? -39.76585 3.78261   29.66754 1.000 38.08386 ? 354 ILE   A CA  1 
ATOM   2130 C  C   . ILE   A 1 354 ? -38.50728 4.60055   29.91558 1.000 41.71174 ? 354 ILE   A C   1 
ATOM   2131 O  O   . ILE   A 1 354 ? -38.55785 5.83388   29.99562 1.000 39.24806 ? 354 ILE   A O   1 
ATOM   2132 C  CB  . ILE   A 1 354 ? -40.21244 3.86587   28.20088 1.000 42.55349 ? 354 ILE   A CB  1 
ATOM   2133 C  CG1 . ILE   A 1 354 ? -41.33223 2.86071   27.93973 1.000 41.91214 ? 354 ILE   A CG1 1 
ATOM   2134 C  CG2 . ILE   A 1 354 ? -39.04532 3.58962   27.27408 1.000 38.87232 ? 354 ILE   A CG2 1 
ATOM   2135 C  CD1 . ILE   A 1 354 ? -42.37071 3.34692   26.96469 1.000 48.95283 ? 354 ILE   A CD1 1 
ATOM   2136 N  N   . SER   A 1 355 ? -37.37757 3.91215   30.05931 1.000 39.04001 ? 355 SER   A N   1 
ATOM   2137 C  CA  . SER   A 1 355 ? -36.10828 4.59658   30.22493 1.000 41.43313 ? 355 SER   A CA  1 
ATOM   2138 C  C   . SER   A 1 355 ? -35.80590 5.43154   28.98188 1.000 37.53955 ? 355 SER   A C   1 
ATOM   2139 O  O   . SER   A 1 355 ? -36.31725 5.14464   27.89503 1.000 42.85597 ? 355 SER   A O   1 
ATOM   2140 C  CB  . SER   A 1 355 ? -34.98418 3.59023   30.46342 1.000 34.88715 ? 355 SER   A CB  1 
ATOM   2141 O  OG  . SER   A 1 355 ? -35.33598 2.65481   31.46707 1.000 34.77503 ? 355 SER   A OG  1 
ATOM   2142 N  N   . PRO   A 1 356 ? -35.00222 6.48530   29.11807 1.000 38.59533 ? 356 PRO   A N   1 
ATOM   2143 C  CA  . PRO   A 1 356 ? -34.56849 7.23617   27.93563 1.000 40.02147 ? 356 PRO   A CA  1 
ATOM   2144 C  C   . PRO   A 1 356 ? -33.99292 6.31716   26.86642 1.000 42.88354 ? 356 PRO   A C   1 
ATOM   2145 O  O   . PRO   A 1 356 ? -33.25398 5.37531   27.16181 1.000 43.37513 ? 356 PRO   A O   1 
ATOM   2146 C  CB  . PRO   A 1 356 ? -33.50596 8.18423   28.49762 1.000 45.93769 ? 356 PRO   A CB  1 
ATOM   2147 C  CG  . PRO   A 1 356 ? -33.95908 8.43790   29.89264 1.000 46.45340 ? 356 PRO   A CG  1 
ATOM   2148 C  CD  . PRO   A 1 356 ? -34.59324 7.14853   30.37014 1.000 41.31521 ? 356 PRO   A CD  1 
ATOM   2149 N  N   . MET   A 1 357 ? -34.36915 6.58549   25.61508 1.000 43.18781 ? 357 MET   A N   1 
ATOM   2150 C  CA  . MET   A 1 357 ? -33.86478 5.92016   24.41556 1.000 38.31786 ? 357 MET   A CA  1 
ATOM   2151 C  C   . MET   A 1 357 ? -34.27740 4.45730   24.30951 1.000 36.33987 ? 357 MET   A C   1 
ATOM   2152 O  O   . MET   A 1 357 ? -33.78906 3.75381   23.41666 1.000 38.39095 ? 357 MET   A O   1 
ATOM   2153 C  CB  . MET   A 1 357 ? -32.33747 6.01283   24.31769 1.000 32.89228 ? 357 MET   A CB  1 
ATOM   2154 C  CG  . MET   A 1 357 ? -31.79523 7.42831   24.35590 1.000 39.80612 ? 357 MET   A CG  1 
ATOM   2155 S  SD  . MET   A 1 357 ? -30.20368 7.52115   25.19584 1.000 54.40012 ? 357 MET   A SD  1 
ATOM   2156 C  CE  . MET   A 1 357 ? -29.60338 9.09894   24.60564 1.000 40.02586 ? 357 MET   A CE  1 
ATOM   2157 N  N   . CYS   A 1 358 ? -35.15578 3.97295   25.18550 1.000 32.94034 ? 358 CYS   A N   1 
ATOM   2158 C  CA  . CYS   A 1 358 ? -35.62597 2.59422   25.13305 1.000 31.85948 ? 358 CYS   A CA  1 
ATOM   2159 C  C   . CYS   A 1 358 ? -36.98916 2.45650   24.46820 1.000 34.98877 ? 358 CYS   A C   1 
ATOM   2160 O  O   . CYS   A 1 358 ? -37.47575 1.33210   24.30878 1.000 30.89734 ? 358 CYS   A O   1 
ATOM   2161 C  CB  . CYS   A 1 358 ? -35.67812 1.99859   26.54443 1.000 33.98385 ? 358 CYS   A CB  1 
ATOM   2162 S  SG  . CYS   A 1 358 ? -34.06737 1.86285   27.35235 1.000 34.19557 ? 358 CYS   A SG  1 
ATOM   2163 N  N   . ASP   A 1 359 ? -37.60937 3.56642   24.07195 1.000 34.85146 ? 359 ASP   A N   1 
ATOM   2164 C  CA  . ASP   A 1 359 ? -38.93267 3.56489   23.45777 1.000 38.95053 ? 359 ASP   A CA  1 
ATOM   2165 C  C   . ASP   A 1 359 ? -38.76827 3.58766   21.94217 1.000 37.63392 ? 359 ASP   A C   1 
ATOM   2166 O  O   . ASP   A 1 359 ? -38.38628 4.61264   21.36997 1.000 43.71978 ? 359 ASP   A O   1 
ATOM   2167 C  CB  . ASP   A 1 359 ? -39.75055 4.76127   23.94048 1.000 43.33002 ? 359 ASP   A CB  1 
ATOM   2168 C  CG  . ASP   A 1 359 ? -41.15709 4.77614   23.37245 1.000 46.61142 ? 359 ASP   A CG  1 
ATOM   2169 O  OD1 . ASP   A 1 359 ? -41.62656 3.71537   22.91047 1.000 38.96903 ? 359 ASP   A OD1 1 
ATOM   2170 O  OD2 . ASP   A 1 359 ? -41.79608 5.85018   23.39482 1.000 49.28875 ? 359 ASP   A OD2 1 
ATOM   2171 N  N   . LYS   A 1 360 ? -39.06870 2.45897   21.29301 1.000 30.65544 ? 360 LYS   A N   1 
ATOM   2172 C  CA  . LYS   A 1 360 ? -38.92403 2.38115   19.84262 1.000 39.66342 ? 360 LYS   A CA  1 
ATOM   2173 C  C   . LYS   A 1 360 ? -39.94256 3.25653   19.12368 1.000 46.10270 ? 360 LYS   A C   1 
ATOM   2174 O  O   . LYS   A 1 360 ? -39.68116 3.71874   18.00723 1.000 47.21952 ? 360 LYS   A O   1 
ATOM   2175 C  CB  . LYS   A 1 360 ? -39.04523 0.92921   19.37782 1.000 33.99939 ? 360 LYS   A CB  1 
ATOM   2176 C  CG  . LYS   A 1 360 ? -40.14442 0.13814   20.06732 1.000 43.89810 ? 360 LYS   A CG  1 
ATOM   2177 C  CD  . LYS   A 1 360 ? -40.24680 -1.26821  19.49687 1.000 39.04145 ? 360 LYS   A CD  1 
ATOM   2178 C  CE  . LYS   A 1 360 ? -41.42500 -2.02134  20.09049 1.000 34.60248 ? 360 LYS   A CE  1 
ATOM   2179 N  NZ  . LYS   A 1 360 ? -41.41833 -3.46179  19.71497 1.000 37.81146 ? 360 LYS   A NZ  1 
ATOM   2180 N  N   . HIS   A 1 361 ? -41.09900 3.49928   19.74096 1.000 38.62512 ? 361 HIS   A N   1 
ATOM   2181 C  CA  . HIS   A 1 361 ? -42.11221 4.35964   19.14536 1.000 46.31393 ? 361 HIS   A CA  1 
ATOM   2182 C  C   . HIS   A 1 361 ? -41.77994 5.83790   19.27681 1.000 45.77414 ? 361 HIS   A C   1 
ATOM   2183 O  O   . HIS   A 1 361 ? -42.50032 6.67252   18.71702 1.000 51.48418 ? 361 HIS   A O   1 
ATOM   2184 C  CB  . HIS   A 1 361 ? -43.47542 4.07899   19.78042 1.000 42.64995 ? 361 HIS   A CB  1 
ATOM   2185 C  CG  . HIS   A 1 361 ? -43.87860 2.63995   19.72250 1.000 38.12769 ? 361 HIS   A CG  1 
ATOM   2186 N  ND1 . HIS   A 1 361 ? -43.85245 1.90709   18.55563 1.000 40.21170 ? 361 HIS   A ND1 1 
ATOM   2187 C  CD2 . HIS   A 1 361 ? -44.31012 1.79525   20.68824 1.000 44.21959 ? 361 HIS   A CD2 1 
ATOM   2188 C  CE1 . HIS   A 1 361 ? -44.25380 0.67349   18.80424 1.000 44.69876 ? 361 HIS   A CE1 1 
ATOM   2189 N  NE2 . HIS   A 1 361 ? -44.53779 0.57942   20.09079 1.000 48.34078 ? 361 HIS   A NE2 1 
ATOM   2190 N  N   . ASN   A 1 362 ? -40.72076 6.17874   20.00007 1.000 42.11845 ? 362 ASN   A N   1 
ATOM   2191 C  CA  . ASN   A 1 362 ? -40.28938 7.56390   20.12038 1.000 47.73875 ? 362 ASN   A CA  1 
ATOM   2192 C  C   . ASN   A 1 362 ? -38.78761 7.58930   20.39230 1.000 48.90850 ? 362 ASN   A C   1 
ATOM   2193 O  O   . ASN   A 1 362 ? -38.31358 8.19218   21.35692 1.000 46.94287 ? 362 ASN   A O   1 
ATOM   2194 C  CB  . ASN   A 1 362 ? -41.07288 8.29264   21.21136 1.000 51.71253 ? 362 ASN   A CB  1 
ATOM   2195 C  CG  . ASN   A 1 362 ? -41.09280 9.79541   21.00876 1.000 55.60238 ? 362 ASN   A CG  1 
ATOM   2196 O  OD1 . ASN   A 1 362 ? -40.14611 10.49442  21.36994 1.000 53.26325 ? 362 ASN   A OD1 1 
ATOM   2197 N  ND2 . ASN   A 1 362 ? -42.17653 10.30078  20.42757 1.000 55.44979 ? 362 ASN   A ND2 1 
ATOM   2198 N  N   . ALA   A 1 363 ? -38.02319 6.90842   19.54323 1.000 38.78470 ? 363 ALA   A N   1 
ATOM   2199 C  CA  . ALA   A 1 363 ? -36.57382 6.89481   19.63164 1.000 41.49935 ? 363 ALA   A CA  1 
ATOM   2200 C  C   . ALA   A 1 363 ? -35.97469 7.79541   18.56233 1.000 41.57316 ? 363 ALA   A C   1 
ATOM   2201 O  O   . ALA   A 1 363 ? -36.53780 7.96897   17.47887 1.000 45.73551 ? 363 ALA   A O   1 
ATOM   2202 C  CB  . ALA   A 1 363 ? -36.02212 5.47757   19.47876 1.000 43.73545 ? 363 ALA   A CB  1 
ATOM   2203 N  N   . SER   A 1 364 ? -34.82324 8.37725   18.88694 1.000 36.44322 ? 364 SER   A N   1 
ATOM   2204 C  CA  . SER   A 1 364 ? -34.03955 9.18029   17.95244 1.000 34.25153 ? 364 SER   A CA  1 
ATOM   2205 C  C   . SER   A 1 364 ? -32.63061 8.59753   17.98513 1.000 28.29858 ? 364 SER   A C   1 
ATOM   2206 O  O   . SER   A 1 364 ? -31.78795 9.03854   18.77095 1.000 27.50784 ? 364 SER   A O   1 
ATOM   2207 C  CB  . SER   A 1 364 ? -34.06719 10.65711  18.32898 1.000 30.78774 ? 364 SER   A CB  1 
ATOM   2208 O  OG  . SER   A 1 364 ? -35.39913 11.10753  18.51316 1.000 47.33646 ? 364 SER   A OG  1 
ATOM   2209 N  N   . VAL   A 1 365 ? -32.38997 7.59520   17.13624 1.000 26.70796 ? 365 VAL   A N   1 
ATOM   2210 C  CA  . VAL   A 1 365 ? -31.12115 6.87001   17.16442 1.000 25.76354 ? 365 VAL   A CA  1 
ATOM   2211 C  C   . VAL   A 1 365 ? -29.95933 7.81191   16.87620 1.000 23.44595 ? 365 VAL   A C   1 
ATOM   2212 O  O   . VAL   A 1 365 ? -28.95424 7.82832   17.59718 1.000 21.74984 ? 365 VAL   A O   1 
ATOM   2213 C  CB  . VAL   A 1 365 ? -31.15335 5.69820   16.16651 1.000 24.52571 ? 365 VAL   A CB  1 
ATOM   2214 C  CG1 . VAL   A 1 365 ? -29.77414 5.06742   16.03979 1.000 19.07082 ? 365 VAL   A CG1 1 
ATOM   2215 C  CG2 . VAL   A 1 365 ? -32.18354 4.66392   16.59305 1.000 22.64257 ? 365 VAL   A CG2 1 
ATOM   2216 N  N   . GLU   A 1 366 ? -30.08564 8.61683   15.82056 1.000 21.92170 ? 366 GLU   A N   1 
ATOM   2217 C  CA  . GLU   A 1 366 ? -28.97449 9.45494   15.38215 1.000 23.94547 ? 366 GLU   A CA  1 
ATOM   2218 C  C   . GLU   A 1 366 ? -28.67363 10.55198  16.39705 1.000 25.98921 ? 366 GLU   A C   1 
ATOM   2219 O  O   . GLU   A 1 366 ? -27.51189 10.77466  16.75867 1.000 23.16736 ? 366 GLU   A O   1 
ATOM   2220 C  CB  . GLU   A 1 366 ? -29.28283 10.05265  14.00783 1.000 28.26594 ? 366 GLU   A CB  1 
ATOM   2221 C  CG  . GLU   A 1 366 ? -29.44700 9.02179   12.88997 1.000 25.67386 ? 366 GLU   A CG  1 
ATOM   2222 C  CD  . GLU   A 1 366 ? -30.77520 8.28625   12.93999 1.000 25.05734 ? 366 GLU   A CD  1 
ATOM   2223 O  OE1 . GLU   A 1 366 ? -30.85224 7.16110   12.40281 1.000 29.70673 ? 366 GLU   A OE1 1 
ATOM   2224 O  OE2 . GLU   A 1 366 ? -31.73994 8.82963   13.51886 1.000 22.90799 ? 366 GLU   A OE2 1 
ATOM   2225 N  N   . LYS   A 1 367 ? -29.71033 11.24927  16.86946 1.000 25.67998 ? 367 LYS   A N   1 
ATOM   2226 C  CA  . LYS   A 1 367 ? -29.50161 12.29351  17.86707 1.000 26.80107 ? 367 LYS   A CA  1 
ATOM   2227 C  C   . LYS   A 1 367 ? -28.94655 11.72424  19.16671 1.000 23.97657 ? 367 LYS   A C   1 
ATOM   2228 O  O   . LYS   A 1 367 ? -28.15601 12.38805  19.84675 1.000 19.46056 ? 367 LYS   A O   1 
ATOM   2229 C  CB  . LYS   A 1 367 ? -30.81051 13.03886  18.13027 1.000 25.74945 ? 367 LYS   A CB  1 
ATOM   2230 C  CG  . LYS   A 1 367 ? -31.29753 13.86940  16.96060 1.000 38.30489 ? 367 LYS   A CG  1 
ATOM   2231 C  CD  . LYS   A 1 367 ? -32.49331 14.74779  17.30528 1.000 37.27822 ? 367 LYS   A CD  1 
ATOM   2232 C  CE  . LYS   A 1 367 ? -32.60862 15.05218  18.78330 1.000 35.44026 ? 367 LYS   A CE  1 
ATOM   2233 N  NZ  . LYS   A 1 367 ? -33.65640 16.07633  19.05624 1.000 38.86108 ? 367 LYS   A NZ  1 
ATOM   2234 N  N   . SER   A 1 368 ? -29.33165 10.49572  19.51947 1.000 21.08830 ? 368 SER   A N   1 
ATOM   2235 C  CA  . SER   A 1 368 ? -28.82908 9.89017   20.74897 1.000 25.77558 ? 368 SER   A CA  1 
ATOM   2236 C  C   . SER   A 1 368 ? -27.34308 9.57108   20.64147 1.000 20.73217 ? 368 SER   A C   1 
ATOM   2237 O  O   . SER   A 1 368 ? -26.59027 9.76958   21.60184 1.000 21.39102 ? 368 SER   A O   1 
ATOM   2238 C  CB  . SER   A 1 368 ? -29.62817 8.62974   21.07905 1.000 25.75583 ? 368 SER   A CB  1 
ATOM   2239 O  OG  . SER   A 1 368 ? -30.96903 8.94778   21.41089 1.000 30.34849 ? 368 SER   A OG  1 
ATOM   2240 N  N   . GLN   A 1 369 ? -26.90245 9.07383   19.48257 1.000 19.06781 ? 369 GLN   A N   1 
ATOM   2241 C  CA  . GLN   A 1 369 ? -25.47801 8.82709   19.28294 1.000 18.28677 ? 369 GLN   A CA  1 
ATOM   2242 C  C   . GLN   A 1 369 ? -24.68331 10.12421  19.34331 1.000 20.75513 ? 369 GLN   A C   1 
ATOM   2243 O  O   . GLN   A 1 369 ? -23.57627 10.15864  19.89378 1.000 17.63548 ? 369 GLN   A O   1 
ATOM   2244 C  CB  . GLN   A 1 369 ? -25.24708 8.11570   17.94990 1.000 19.96348 ? 369 GLN   A CB  1 
ATOM   2245 C  CG  . GLN   A 1 369 ? -25.58160 6.63560   17.97707 1.000 17.31451 ? 369 GLN   A CG  1 
ATOM   2246 C  CD  . GLN   A 1 369 ? -24.88145 5.90676   19.10731 1.000 17.38227 ? 369 GLN   A CD  1 
ATOM   2247 O  OE1 . GLN   A 1 369 ? -23.65593 5.94177   19.22032 1.000 12.51846 ? 369 GLN   A OE1 1 
ATOM   2248 N  NE2 . GLN   A 1 369 ? -25.66029 5.24617   19.95633 1.000 15.34938 ? 369 GLN   A NE2 1 
ATOM   2249 N  N   . VAL   A 1 370 ? -25.23672 11.20436  18.78828 1.000 18.65842 ? 370 VAL   A N   1 
ATOM   2250 C  CA  . VAL   A 1 370 ? -24.56148 12.49755  18.84219 1.000 18.14973 ? 370 VAL   A CA  1 
ATOM   2251 C  C   . VAL   A 1 370 ? -24.43918 12.97613  20.28373 1.000 19.30868 ? 370 VAL   A C   1 
ATOM   2252 O  O   . VAL   A 1 370 ? -23.37751 13.44842  20.70786 1.000 17.65442 ? 370 VAL   A O   1 
ATOM   2253 C  CB  . VAL   A 1 370 ? -25.29993 13.52186  17.96084 1.000 25.54974 ? 370 VAL   A CB  1 
ATOM   2254 C  CG1 . VAL   A 1 370 ? -24.76523 14.92373  18.21060 1.000 20.02046 ? 370 VAL   A CG1 1 
ATOM   2255 C  CG2 . VAL   A 1 370 ? -25.16078 13.14815  16.49224 1.000 22.25449 ? 370 VAL   A CG2 1 
ATOM   2256 N  N   . GLY   A 1 371 ? -25.51682 12.85727  21.06166 1.000 17.75097 ? 371 GLY   A N   1 
ATOM   2257 C  CA  . GLY   A 1 371 ? -25.44611 13.24304  22.46205 1.000 22.40708 ? 371 GLY   A CA  1 
ATOM   2258 C  C   . GLY   A 1 371 ? -24.55415 12.32201  23.27205 1.000 20.22891 ? 371 GLY   A C   1 
ATOM   2259 O  O   . GLY   A 1 371 ? -23.85553 12.76557  24.18814 1.000 23.36558 ? 371 GLY   A O   1 
ATOM   2260 N  N   . PHE   A 1 372 ? -24.57118 11.02729  22.94737 1.000 20.36591 ? 372 PHE   A N   1 
ATOM   2261 C  CA  . PHE   A 1 372 ? -23.68194 10.06805  23.59564 1.000 20.78652 ? 372 PHE   A CA  1 
ATOM   2262 C  C   . PHE   A 1 372 ? -22.22302 10.46171  23.39956 1.000 18.62731 ? 372 PHE   A C   1 
ATOM   2263 O  O   . PHE   A 1 372 ? -21.43370 10.46925  24.35140 1.000 17.47970 ? 372 PHE   A O   1 
ATOM   2264 C  CB  . PHE   A 1 372 ? -23.96163 8.67024   23.03690 1.000 17.41338 ? 372 PHE   A CB  1 
ATOM   2265 C  CG  . PHE   A 1 372 ? -23.15805 7.56921   23.67300 1.000 23.65781 ? 372 PHE   A CG  1 
ATOM   2266 C  CD1 . PHE   A 1 372 ? -23.07358 7.44659   25.05038 1.000 19.93695 ? 372 PHE   A CD1 1 
ATOM   2267 C  CD2 . PHE   A 1 372 ? -22.52246 6.62517   22.88188 1.000 19.40913 ? 372 PHE   A CD2 1 
ATOM   2268 C  CE1 . PHE   A 1 372 ? -22.34358 6.41777   25.62465 1.000 21.64035 ? 372 PHE   A CE1 1 
ATOM   2269 C  CE2 . PHE   A 1 372 ? -21.79747 5.59462   23.44796 1.000 19.86040 ? 372 PHE   A CE2 1 
ATOM   2270 C  CZ  . PHE   A 1 372 ? -21.70647 5.49064   24.82135 1.000 19.35148 ? 372 PHE   A CZ  1 
ATOM   2271 N  N   . ILE   A 1 373 ? -21.85329 10.81512  22.16805 1.000 17.67243 ? 373 ILE   A N   1 
ATOM   2272 C  CA  . ILE   A 1 373 ? -20.48660 11.24607  21.89197 1.000 18.21166 ? 373 ILE   A CA  1 
ATOM   2273 C  C   . ILE   A 1 373 ? -20.19526 12.57558  22.57853 1.000 17.42848 ? 373 ILE   A C   1 
ATOM   2274 O  O   . ILE   A 1 373 ? -19.16100 12.73970  23.23645 1.000 17.68250 ? 373 ILE   A O   1 
ATOM   2275 C  CB  . ILE   A 1 373 ? -20.25250 11.33679  20.37317 1.000 17.93020 ? 373 ILE   A CB  1 
ATOM   2276 C  CG1 . ILE   A 1 373 ? -20.30988 9.94789   19.73431 1.000 19.85014 ? 373 ILE   A CG1 1 
ATOM   2277 C  CG2 . ILE   A 1 373 ? -18.92512 12.01640  20.07648 1.000 14.23581 ? 373 ILE   A CG2 1 
ATOM   2278 C  CD1 . ILE   A 1 373 ? -20.27278 9.97284   18.21927 1.000 15.92017 ? 373 ILE   A CD1 1 
ATOM   2279 N  N   . ASP   A 1 374 ? -21.10908 13.54081  22.44380 1.000 21.47136 ? 374 ASP   A N   1 
ATOM   2280 C  CA  . ASP   A 1 374 ? -20.82910 14.90126  22.89580 1.000 20.85164 ? 374 ASP   A CA  1 
ATOM   2281 C  C   . ASP   A 1 374 ? -20.68052 14.97962  24.41133 1.000 21.68214 ? 374 ASP   A C   1 
ATOM   2282 O  O   . ASP   A 1 374 ? -19.84487 15.73815  24.91683 1.000 21.84623 ? 374 ASP   A O   1 
ATOM   2283 C  CB  . ASP   A 1 374 ? -21.92947 15.85114  22.41958 1.000 15.21631 ? 374 ASP   A CB  1 
ATOM   2284 C  CG  . ASP   A 1 374 ? -21.83701 16.15709  20.93537 1.000 18.68277 ? 374 ASP   A CG  1 
ATOM   2285 O  OD1 . ASP   A 1 374 ? -20.79219 15.84850  20.32567 1.000 17.30758 ? 374 ASP   A OD1 1 
ATOM   2286 O  OD2 . ASP   A 1 374 ? -22.80694 16.71439  20.37895 1.000 21.22251 ? 374 ASP   A OD2 1 
ATOM   2287 N  N   . TYR   A 1 375 ? -21.47356 14.20802  25.15499 1.000 16.19450 ? 375 TYR   A N   1 
ATOM   2288 C  CA  . TYR   A 1 375 ? -21.50288 14.34505  26.60536 1.000 20.52126 ? 375 TYR   A CA  1 
ATOM   2289 C  C   . TYR   A 1 375 ? -20.74820 13.25022  27.34807 1.000 21.14374 ? 375 TYR   A C   1 
ATOM   2290 O  O   . TYR   A 1 375 ? -20.46596 13.42081  28.53973 1.000 19.25344 ? 375 TYR   A O   1 
ATOM   2291 C  CB  . TYR   A 1 375 ? -22.95204 14.37776  27.10598 1.000 19.21827 ? 375 TYR   A CB  1 
ATOM   2292 C  CG  . TYR   A 1 375 ? -23.70316 15.63960  26.74021 1.000 25.26650 ? 375 TYR   A CG  1 
ATOM   2293 C  CD1 . TYR   A 1 375 ? -23.59412 16.78491  27.51936 1.000 28.28726 ? 375 TYR   A CD1 1 
ATOM   2294 C  CD2 . TYR   A 1 375 ? -24.52544 15.68403  25.62125 1.000 30.43662 ? 375 TYR   A CD2 1 
ATOM   2295 C  CE1 . TYR   A 1 375 ? -24.27978 17.94029  27.19258 1.000 32.75765 ? 375 TYR   A CE1 1 
ATOM   2296 C  CE2 . TYR   A 1 375 ? -25.21561 16.83522  25.28621 1.000 34.22387 ? 375 TYR   A CE2 1 
ATOM   2297 C  CZ  . TYR   A 1 375 ? -25.08855 17.95957  26.07561 1.000 37.35662 ? 375 TYR   A CZ  1 
ATOM   2298 O  OH  . TYR   A 1 375 ? -25.77320 19.10641  25.74605 1.000 42.75160 ? 375 TYR   A OH  1 
ATOM   2299 N  N   . ILE   A 1 376 ? -20.41444 12.13982  26.69144 1.000 20.63498 ? 376 ILE   A N   1 
ATOM   2300 C  CA  . ILE   A 1 376 ? -19.75352 11.03226  27.37457 1.000 19.41456 ? 376 ILE   A CA  1 
ATOM   2301 C  C   . ILE   A 1 376 ? -18.46504 10.64815  26.66031 1.000 20.60795 ? 376 ILE   A C   1 
ATOM   2302 O  O   . ILE   A 1 376 ? -17.36931 10.76006  27.22246 1.000 17.86625 ? 376 ILE   A O   1 
ATOM   2303 C  CB  . ILE   A 1 376 ? -20.67757 9.80505   27.47977 1.000 22.27551 ? 376 ILE   A CB  1 
ATOM   2304 C  CG1 . ILE   A 1 376 ? -22.05210 10.19092  28.03211 1.000 23.50949 ? 376 ILE   A CG1 1 
ATOM   2305 C  CG2 . ILE   A 1 376 ? -20.02315 8.73468   28.33998 1.000 20.42825 ? 376 ILE   A CG2 1 
ATOM   2306 C  CD1 . ILE   A 1 376 ? -22.04059 10.59163  29.48796 1.000 28.12877 ? 376 ILE   A CD1 1 
ATOM   2307 N  N   . VAL   A 1 377 ? -18.59464 10.19350  25.41316 1.000 16.17308 ? 377 VAL   A N   1 
ATOM   2308 C  CA  . VAL   A 1 377 ? -17.50734 9.47033   24.75954 1.000 17.73052 ? 377 VAL   A CA  1 
ATOM   2309 C  C   . VAL   A 1 377 ? -16.37250 10.41448  24.38232 1.000 17.41763 ? 377 VAL   A C   1 
ATOM   2310 O  O   . VAL   A 1 377 ? -15.19545 10.11551  24.61561 1.000 16.80865 ? 377 VAL   A O   1 
ATOM   2311 C  CB  . VAL   A 1 377 ? -18.04019 8.70662   23.53547 1.000 16.19774 ? 377 VAL   A CB  1 
ATOM   2312 C  CG1 . VAL   A 1 377 ? -16.92375 7.91492   22.87310 1.000 13.43492 ? 377 VAL   A CG1 1 
ATOM   2313 C  CG2 . VAL   A 1 377 ? -19.17287 7.79245   23.95408 1.000 13.77333 ? 377 VAL   A CG2 1 
ATOM   2314 N  N   . HIS   A 1 378 ? -16.70096 11.56245  23.77965 1.000 17.49154 ? 378 HIS   A N   1 
ATOM   2315 C  CA  . HIS   A 1 378 ? -15.63894 12.48747  23.38499 1.000 18.30174 ? 378 HIS   A CA  1 
ATOM   2316 C  C   . HIS   A 1 378 ? -14.95869 13.13326  24.58525 1.000 17.66671 ? 378 HIS   A C   1 
ATOM   2317 O  O   . HIS   A 1 378 ? -13.71683 13.19535  24.59738 1.000 15.60137 ? 378 HIS   A O   1 
ATOM   2318 C  CB  . HIS   A 1 378 ? -16.17736 13.53447  22.40620 1.000 16.34627 ? 378 HIS   A CB  1 
ATOM   2319 C  CG  . HIS   A 1 378 ? -15.10351 14.35528  21.76204 1.000 19.74536 ? 378 HIS   A CG  1 
ATOM   2320 N  ND1 . HIS   A 1 378 ? -14.52652 15.44422  22.37957 1.000 22.36892 ? 378 HIS   A ND1 1 
ATOM   2321 C  CD2 . HIS   A 1 378 ? -14.49007 14.23605  20.56070 1.000 20.74313 ? 378 HIS   A CD2 1 
ATOM   2322 C  CE1 . HIS   A 1 378 ? -13.60958 15.96492  21.58350 1.000 24.98631 ? 378 HIS   A CE1 1 
ATOM   2323 N  NE2 . HIS   A 1 378 ? -13.56744 15.25037  20.47340 1.000 24.06618 ? 378 HIS   A NE2 1 
ATOM   2324 N  N   . PRO   A 1 379 ? -15.67245 13.63881  25.60413 1.000 17.67529 ? 379 PRO   A N   1 
ATOM   2325 C  CA  . PRO   A 1 379 ? -14.96080 14.13394  26.79694 1.000 18.43313 ? 379 PRO   A CA  1 
ATOM   2326 C  C   . PRO   A 1 379 ? -14.00544 13.11127  27.38355 1.000 22.05951 ? 379 PRO   A C   1 
ATOM   2327 O  O   . PRO   A 1 379 ? -12.89077 13.46041  27.79231 1.000 22.25378 ? 379 PRO   A O   1 
ATOM   2328 C  CB  . PRO   A 1 379 ? -16.10115 14.46579  27.76767 1.000 17.68612 ? 379 PRO   A CB  1 
ATOM   2329 C  CG  . PRO   A 1 379 ? -17.24707 14.79163  26.89054 1.000 23.05931 ? 379 PRO   A CG  1 
ATOM   2330 C  CD  . PRO   A 1 379 ? -17.12536 13.88123  25.70302 1.000 15.13129 ? 379 PRO   A CD  1 
ATOM   2331 N  N   . LEU   A 1 380 ? -14.41630 11.84385  27.41626 1.000 17.52896 ? 380 LEU   A N   1 
ATOM   2332 C  CA  . LEU   A 1 380 ? -13.55125 10.78200  27.91534 1.000 16.25330 ? 380 LEU   A CA  1 
ATOM   2333 C  C   . LEU   A 1 380 ? -12.33604 10.59522  27.01457 1.000 19.05167 ? 380 LEU   A C   1 
ATOM   2334 O  O   . LEU   A 1 380 ? -11.18928 10.64411  27.47363 1.000 16.72701 ? 380 LEU   A O   1 
ATOM   2335 C  CB  . LEU   A 1 380 ? -14.34912 9.48201   28.02655 1.000 13.01847 ? 380 LEU   A CB  1 
ATOM   2336 C  CG  . LEU   A 1 380 ? -13.58451 8.20790   28.38481 1.000 18.75463 ? 380 LEU   A CG  1 
ATOM   2337 C  CD1 . LEU   A 1 380 ? -12.96295 8.32539   29.76533 1.000 15.98298 ? 380 LEU   A CD1 1 
ATOM   2338 C  CD2 . LEU   A 1 380 ? -14.50480 6.99652   28.30401 1.000 14.10233 ? 380 LEU   A CD2 1 
ATOM   2339 N  N   . TRP   A 1 381 ? -12.57129 10.38274  25.71786 1.000 18.08422 ? 381 TRP   A N   1 
ATOM   2340 C  CA  . TRP   A 1 381 ? -11.47114 10.06473  24.81398 1.000 14.65335 ? 381 TRP   A CA  1 
ATOM   2341 C  C   . TRP   A 1 381 ? -10.57058 11.26529  24.55932 1.000 17.74720 ? 381 TRP   A C   1 
ATOM   2342 O  O   . TRP   A 1 381 ? -9.37006  11.09363  24.31918 1.000 17.03187 ? 381 TRP   A O   1 
ATOM   2343 C  CB  . TRP   A 1 381 ? -12.01835 9.51290   23.50089 1.000 12.95146 ? 381 TRP   A CB  1 
ATOM   2344 C  CG  . TRP   A 1 381 ? -12.24777 8.04669   23.56945 1.000 16.44283 ? 381 TRP   A CG  1 
ATOM   2345 C  CD1 . TRP   A 1 381 ? -13.42974 7.40646   23.80196 1.000 12.43636 ? 381 TRP   A CD1 1 
ATOM   2346 C  CD2 . TRP   A 1 381 ? -11.25574 7.02597   23.43550 1.000 15.24252 ? 381 TRP   A CD2 1 
ATOM   2347 N  NE1 . TRP   A 1 381 ? -13.23576 6.04573   23.80644 1.000 15.05010 ? 381 TRP   A NE1 1 
ATOM   2348 C  CE2 . TRP   A 1 381 ? -11.90823 5.78711   23.58420 1.000 13.62104 ? 381 TRP   A CE2 1 
ATOM   2349 C  CE3 . TRP   A 1 381 ? -9.87797  7.03973   23.19700 1.000 16.22536 ? 381 TRP   A CE3 1 
ATOM   2350 C  CZ2 . TRP   A 1 381 ? -11.23027 4.57305   23.50121 1.000 13.67315 ? 381 TRP   A CZ2 1 
ATOM   2351 C  CZ3 . TRP   A 1 381 ? -9.20643  5.83464   23.11558 1.000 20.50970 ? 381 TRP   A CZ3 1 
ATOM   2352 C  CH2 . TRP   A 1 381 ? -9.88281  4.61802   23.26722 1.000 14.86913 ? 381 TRP   A CH2 1 
ATOM   2353 N  N   . GLU   A 1 382 ? -11.12387 12.47854  24.59676 1.000 21.48243 ? 382 GLU   A N   1 
ATOM   2354 C  CA  . GLU   A 1 382 ? -10.28695 13.66996  24.50670 1.000 23.05041 ? 382 GLU   A CA  1 
ATOM   2355 C  C   . GLU   A 1 382 ? -9.33625  13.75422  25.69353 1.000 22.57508 ? 382 GLU   A C   1 
ATOM   2356 O  O   . GLU   A 1 382 ? -8.17450  14.15292  25.54526 1.000 21.04128 ? 382 GLU   A O   1 
ATOM   2357 C  CB  . GLU   A 1 382 ? -11.16794 14.91604  24.42588 1.000 20.19171 ? 382 GLU   A CB  1 
ATOM   2358 C  CG  . GLU   A 1 382 ? -10.42201 16.23049  24.33625 1.000 28.43335 ? 382 GLU   A CG  1 
ATOM   2359 C  CD  . GLU   A 1 382 ? -11.36389 17.40359  24.15527 1.000 29.51791 ? 382 GLU   A CD  1 
ATOM   2360 O  OE1 . GLU   A 1 382 ? -12.37369 17.46989  24.88762 1.000 29.23700 ? 382 GLU   A OE1 1 
ATOM   2361 O  OE2 . GLU   A 1 382 ? -11.10224 18.25142  23.27649 1.000 38.32500 ? 382 GLU   A OE2 1 
ATOM   2362 N  N   . THR   A 1 383 ? -9.81108  13.36817  26.88011 1.000 18.13002 ? 383 THR   A N   1 
ATOM   2363 C  CA  . THR   A 1 383 ? -8.95314  13.37438  28.05942 1.000 18.61499 ? 383 THR   A CA  1 
ATOM   2364 C  C   . THR   A 1 383 ? -7.91070  12.26548  27.98700 1.000 22.70690 ? 383 THR   A C   1 
ATOM   2365 O  O   . THR   A 1 383 ? -6.73657  12.49004  28.30404 1.000 17.26618 ? 383 THR   A O   1 
ATOM   2366 C  CB  . THR   A 1 383 ? -9.79803  13.23595  29.32561 1.000 15.88165 ? 383 THR   A CB  1 
ATOM   2367 O  OG1 . THR   A 1 383 ? -10.84047 14.21944  29.31563 1.000 18.22157 ? 383 THR   A OG1 1 
ATOM   2368 C  CG2 . THR   A 1 383 ? -8.93812  13.44235  30.56058 1.000 19.02387 ? 383 THR   A CG2 1 
ATOM   2369 N  N   . TRP   A 1 384 ? -8.31799  11.06210  27.57245 1.000 17.96995 ? 384 TRP   A N   1 
ATOM   2370 C  CA  . TRP   A 1 384 ? -7.35006  9.98433   27.39644 1.000 19.22440 ? 384 TRP   A CA  1 
ATOM   2371 C  C   . TRP   A 1 384 ? -6.30560  10.35136  26.35184 1.000 24.20236 ? 384 TRP   A C   1 
ATOM   2372 O  O   . TRP   A 1 384 ? -5.11614  10.05752  26.52208 1.000 20.88711 ? 384 TRP   A O   1 
ATOM   2373 C  CB  . TRP   A 1 384 ? -8.05447  8.68704   27.00170 1.000 17.87741 ? 384 TRP   A CB  1 
ATOM   2374 C  CG  . TRP   A 1 384 ? -7.09521  7.55368   26.81650 1.000 16.83192 ? 384 TRP   A CG  1 
ATOM   2375 C  CD1 . TRP   A 1 384 ? -6.52916  7.13650   25.64577 1.000 15.06199 ? 384 TRP   A CD1 1 
ATOM   2376 C  CD2 . TRP   A 1 384 ? -6.57095  6.70327   27.84101 1.000 15.19133 ? 384 TRP   A CD2 1 
ATOM   2377 N  NE1 . TRP   A 1 384 ? -5.69069  6.07251   25.87897 1.000 14.24728 ? 384 TRP   A NE1 1 
ATOM   2378 C  CE2 . TRP   A 1 384 ? -5.69882  5.78777   27.21938 1.000 12.39919 ? 384 TRP   A CE2 1 
ATOM   2379 C  CE3 . TRP   A 1 384 ? -6.75862  6.62408   29.22408 1.000 15.56962 ? 384 TRP   A CE3 1 
ATOM   2380 C  CZ2 . TRP   A 1 384 ? -5.01640  4.80551   27.93369 1.000 15.43450 ? 384 TRP   A CZ2 1 
ATOM   2381 C  CZ3 . TRP   A 1 384 ? -6.08087  5.64961   29.93104 1.000 14.79874 ? 384 TRP   A CZ3 1 
ATOM   2382 C  CH2 . TRP   A 1 384 ? -5.22017  4.75333   29.28541 1.000 12.69082 ? 384 TRP   A CH2 1 
ATOM   2383 N  N   . ALA   A 1 385 ? -6.73369  10.99096  25.25995 1.000 20.75388 ? 385 ALA   A N   1 
ATOM   2384 C  CA  . ALA   A 1 385 ? -5.78883  11.40785  24.22975 1.000 25.52236 ? 385 ALA   A CA  1 
ATOM   2385 C  C   . ALA   A 1 385 ? -4.77990  12.40555  24.78152 1.000 23.22082 ? 385 ALA   A C   1 
ATOM   2386 O  O   . ALA   A 1 385 ? -3.59250  12.34667  24.44436 1.000 27.79718 ? 385 ALA   A O   1 
ATOM   2387 C  CB  . ALA   A 1 385 ? -6.53595  12.00183  23.03602 1.000 21.64079 ? 385 ALA   A CB  1 
ATOM   2388 N  N   . ASP   A 1 386 ? -5.23354  13.33086  25.63175 1.000 23.31211 ? 386 ASP   A N   1 
ATOM   2389 C  CA  . ASP   A 1 386 ? -4.30442  14.24289  26.29193 1.000 27.32743 ? 386 ASP   A CA  1 
ATOM   2390 C  C   . ASP   A 1 386 ? -3.29277  13.47924  27.13582 1.000 27.45222 ? 386 ASP   A C   1 
ATOM   2391 O  O   . ASP   A 1 386 ? -2.09939  13.80380  27.13397 1.000 30.18856 ? 386 ASP   A O   1 
ATOM   2392 C  CB  . ASP   A 1 386 ? -5.06811  15.24283  27.16142 1.000 28.66292 ? 386 ASP   A CB  1 
ATOM   2393 C  CG  . ASP   A 1 386 ? -5.69332  16.36458  26.35669 1.000 34.36756 ? 386 ASP   A CG  1 
ATOM   2394 O  OD1 . ASP   A 1 386 ? -5.28645  16.56750  25.19339 1.000 38.18137 ? 386 ASP   A OD1 1 
ATOM   2395 O  OD2 . ASP   A 1 386 ? -6.58779  17.05124  26.89461 1.000 32.61422 ? 386 ASP   A OD2 1 
ATOM   2396 N  N   . LEU   A 1 387 ? -3.75286  12.45342  27.85689 1.000 24.30584 ? 387 LEU   A N   1 
ATOM   2397 C  CA  . LEU   A 1 387 ? -2.86951  11.71066  28.75017 1.000 23.36523 ? 387 LEU   A CA  1 
ATOM   2398 C  C   . LEU   A 1 387 ? -1.75153  11.01625  27.98234 1.000 27.33680 ? 387 LEU   A C   1 
ATOM   2399 O  O   . LEU   A 1 387 ? -0.61718  10.92900  28.46710 1.000 30.40828 ? 387 LEU   A O   1 
ATOM   2400 C  CB  . LEU   A 1 387 ? -3.67672  10.68876  29.55065 1.000 24.56176 ? 387 LEU   A CB  1 
ATOM   2401 C  CG  . LEU   A 1 387 ? -2.89351  9.86723   30.57663 1.000 21.44909 ? 387 LEU   A CG  1 
ATOM   2402 C  CD1 . LEU   A 1 387 ? -2.69744  10.65840  31.86326 1.000 22.06810 ? 387 LEU   A CD1 1 
ATOM   2403 C  CD2 . LEU   A 1 387 ? -3.57520  8.53353   30.85042 1.000 21.82223 ? 387 LEU   A CD2 1 
ATOM   2404 N  N   . VAL   A 1 388 ? -2.04875  10.51777  26.78629 1.000 23.73169 ? 388 VAL   A N   1 
ATOM   2405 C  CA  . VAL   A 1 388 ? -1.09177  9.75153   26.00057 1.000 25.13797 ? 388 VAL   A CA  1 
ATOM   2406 C  C   . VAL   A 1 388 ? -0.69696  10.49224  24.72222 1.000 25.17019 ? 388 VAL   A C   1 
ATOM   2407 O  O   . VAL   A 1 388 ? -0.20259  9.87768   23.78025 1.000 23.76616 ? 388 VAL   A O   1 
ATOM   2408 C  CB  . VAL   A 1 388 ? -1.63291  8.34597   25.68936 1.000 24.05898 ? 388 VAL   A CB  1 
ATOM   2409 C  CG1 . VAL   A 1 388 ? -2.08371  7.66032   26.97023 1.000 22.24750 ? 388 VAL   A CG1 1 
ATOM   2410 C  CG2 . VAL   A 1 388 ? -2.78304  8.42084   24.69161 1.000 18.29006 ? 388 VAL   A CG2 1 
ATOM   2411 N  N   . HIS   A 1 389 ? -0.89746  11.80709  24.68642 1.000 25.96014 ? 389 HIS   A N   1 
ATOM   2412 C  CA  . HIS   A 1 389 ? -0.63088  12.62492  23.50195 1.000 29.07163 ? 389 HIS   A CA  1 
ATOM   2413 C  C   . HIS   A 1 389 ? 0.76649   12.38167  22.92957 1.000 31.54012 ? 389 HIS   A C   1 
ATOM   2414 O  O   . HIS   A 1 389 ? 1.75119   12.37940  23.66938 1.000 34.35406 ? 389 HIS   A O   1 
ATOM   2415 C  CB  . HIS   A 1 389 ? -0.81114  14.10609  23.85089 1.000 32.62748 ? 389 HIS   A CB  1 
ATOM   2416 C  CG  . HIS   A 1 389 ? -0.93586  15.00345  22.65915 1.000 38.39547 ? 389 HIS   A CG  1 
ATOM   2417 N  ND1 . HIS   A 1 389 ? 0.09175   15.19851  21.76399 1.000 44.01718 ? 389 HIS   A ND1 1 
ATOM   2418 C  CD2 . HIS   A 1 389 ? -1.96379  15.76858  22.22170 1.000 37.59455 ? 389 HIS   A CD2 1 
ATOM   2419 C  CE1 . HIS   A 1 389 ? -0.29645  16.04010  20.82326 1.000 41.35982 ? 389 HIS   A CE1 1 
ATOM   2420 N  NE2 . HIS   A 1 389 ? -1.54079  16.40122  21.07752 1.000 44.72739 ? 389 HIS   A NE2 1 
ATOM   2421 N  N   . PRO   A 1 390 ? 0.85943   12.18335  21.60344 1.000 28.95011 ? 390 PRO   A N   1 
ATOM   2422 C  CA  . PRO   A 1 390 ? -0.22369  12.22993  20.61772 1.000 30.98004 ? 390 PRO   A CA  1 
ATOM   2423 C  C   . PRO   A 1 390 ? -0.71313  10.85782  20.17715 1.000 26.02367 ? 390 PRO   A C   1 
ATOM   2424 O  O   . PRO   A 1 390 ? -1.32507  10.74918  19.11492 1.000 23.02770 ? 390 PRO   A O   1 
ATOM   2425 C  CB  . PRO   A 1 390 ? 0.43976   12.93835  19.44423 1.000 30.46614 ? 390 PRO   A CB  1 
ATOM   2426 C  CG  . PRO   A 1 390 ? 1.84094   12.36642  19.47119 1.000 29.38628 ? 390 PRO   A CG  1 
ATOM   2427 C  CD  . PRO   A 1 390 ? 2.16845   12.07614  20.93525 1.000 32.56318 ? 390 PRO   A CD  1 
ATOM   2428 N  N   . ASP   A 1 391 ? -0.44696  9.83229   20.98918 1.000 20.87612 ? 391 ASP   A N   1 
ATOM   2429 C  CA  . ASP   A 1 391 ? -0.61303  8.45454   20.53465 1.000 26.34702 ? 391 ASP   A CA  1 
ATOM   2430 C  C   . ASP   A 1 391 ? -2.03008  8.15993   20.05520 1.000 20.44884 ? 391 ASP   A C   1 
ATOM   2431 O  O   . ASP   A 1 391 ? -2.22367  7.27946   19.20915 1.000 24.64650 ? 391 ASP   A O   1 
ATOM   2432 C  CB  . ASP   A 1 391 ? -0.24437  7.48730   21.65354 1.000 26.11141 ? 391 ASP   A CB  1 
ATOM   2433 C  CG  . ASP   A 1 391 ? 1.14227   7.72991   22.21271 1.000 31.36794 ? 391 ASP   A CG  1 
ATOM   2434 O  OD1 . ASP   A 1 391 ? 1.87949   8.56761   21.65408 1.000 26.23293 ? 391 ASP   A OD1 1 
ATOM   2435 O  OD2 . ASP   A 1 391 ? 1.49153   7.07561   23.21814 1.000 28.96980 ? 391 ASP   A OD2 1 
ATOM   2436 N  N   . ALA   A 1 392 ? -3.02941  8.87361   20.57452 1.000 19.78984 ? 392 ALA   A N   1 
ATOM   2437 C  CA  . ALA   A 1 392 ? -4.42761  8.55882   20.31219 1.000 20.24345 ? 392 ALA   A CA  1 
ATOM   2438 C  C   . ALA   A 1 392 ? -5.07336  9.50089   19.29996 1.000 18.55131 ? 392 ALA   A C   1 
ATOM   2439 O  O   . ALA   A 1 392 ? -6.30422  9.52974   19.19389 1.000 18.62793 ? 392 ALA   A O   1 
ATOM   2440 C  CB  . ALA   A 1 392 ? -5.22048  8.57376   21.61932 1.000 17.60678 ? 392 ALA   A CB  1 
ATOM   2441 N  N   . GLN   A 1 393 ? -4.27287  10.25461  18.54072 1.000 19.53560 ? 393 GLN   A N   1 
ATOM   2442 C  CA  . GLN   A 1 393 ? -4.83558  11.29138  17.67794 1.000 26.08539 ? 393 GLN   A CA  1 
ATOM   2443 C  C   . GLN   A 1 393 ? -5.71449  10.69912  16.58065 1.000 20.75006 ? 393 GLN   A C   1 
ATOM   2444 O  O   . GLN   A 1 393 ? -6.75801  11.26860  16.24042 1.000 22.49769 ? 393 GLN   A O   1 
ATOM   2445 C  CB  . GLN   A 1 393 ? -3.71484  12.13675  17.07290 1.000 25.65840 ? 393 GLN   A CB  1 
ATOM   2446 C  CG  . GLN   A 1 393 ? -4.20532  13.32610  16.25800 1.000 27.31240 ? 393 GLN   A CG  1 
ATOM   2447 C  CD  . GLN   A 1 393 ? -5.23062  14.16335  16.99993 1.000 31.37002 ? 393 GLN   A CD  1 
ATOM   2448 O  OE1 . GLN   A 1 393 ? -4.94113  14.73306  18.05182 1.000 34.78759 ? 393 GLN   A OE1 1 
ATOM   2449 N  NE2 . GLN   A 1 393 ? -6.43798  14.24275  16.45174 1.000 34.74575 ? 393 GLN   A NE2 1 
ATOM   2450 N  N   . ASP   A 1 394 ? -5.31414  9.55694   16.01447 1.000 17.47728 ? 394 ASP   A N   1 
ATOM   2451 C  CA  . ASP   A 1 394 ? -6.11282  8.94749   14.95358 1.000 20.64623 ? 394 ASP   A CA  1 
ATOM   2452 C  C   . ASP   A 1 394 ? -7.43220  8.40904   15.49242 1.000 20.75543 ? 394 ASP   A C   1 
ATOM   2453 O  O   . ASP   A 1 394 ? -8.46806  8.50458   14.82328 1.000 21.14340 ? 394 ASP   A O   1 
ATOM   2454 C  CB  . ASP   A 1 394 ? -5.32365  7.83264   14.26925 1.000 21.35436 ? 394 ASP   A CB  1 
ATOM   2455 C  CG  . ASP   A 1 394 ? -4.04809  8.33222   13.62541 1.000 29.13800 ? 394 ASP   A CG  1 
ATOM   2456 O  OD1 . ASP   A 1 394 ? -3.94457  9.55086   13.37167 1.000 29.33170 ? 394 ASP   A OD1 1 
ATOM   2457 O  OD2 . ASP   A 1 394 ? -3.15060  7.50399   13.36807 1.000 28.53111 ? 394 ASP   A OD2 1 
ATOM   2458 N  N   . ILE   A 1 395 ? -7.41055  7.83063   16.69484 1.000 20.66701 ? 395 ILE   A N   1 
ATOM   2459 C  CA  . ILE   A 1 395 ? -8.64055  7.35133   17.31812 1.000 17.83629 ? 395 ILE   A CA  1 
ATOM   2460 C  C   . ILE   A 1 395 ? -9.58949  8.51261   17.58064 1.000 17.92541 ? 395 ILE   A C   1 
ATOM   2461 O  O   . ILE   A 1 395 ? -10.79513 8.42444   17.31474 1.000 17.73111 ? 395 ILE   A O   1 
ATOM   2462 C  CB  . ILE   A 1 395 ? -8.30919  6.58270   18.61050 1.000 18.83519 ? 395 ILE   A CB  1 
ATOM   2463 C  CG1 . ILE   A 1 395 ? -7.47867  5.34003   18.29012 1.000 21.69365 ? 395 ILE   A CG1 1 
ATOM   2464 C  CG2 . ILE   A 1 395 ? -9.57509  6.20754   19.35723 1.000 14.56234 ? 395 ILE   A CG2 1 
ATOM   2465 C  CD1 . ILE   A 1 395 ? -7.01366  4.59117   19.51507 1.000 18.86543 ? 395 ILE   A CD1 1 
ATOM   2466 N  N   . LEU   A 1 396 ? -9.05848  9.62123   18.10058 1.000 21.29708 ? 396 LEU   A N   1 
ATOM   2467 C  CA  . LEU   A 1 396 ? -9.88347  10.79813  18.35173 1.000 22.55701 ? 396 LEU   A CA  1 
ATOM   2468 C  C   . LEU   A 1 396 ? -10.41762 11.38409  17.04990 1.000 17.34729 ? 396 LEU   A C   1 
ATOM   2469 O  O   . LEU   A 1 396 ? -11.55416 11.86954  16.99934 1.000 21.33386 ? 396 LEU   A O   1 
ATOM   2470 C  CB  . LEU   A 1 396 ? -9.07231  11.84101  19.12258 1.000 21.04660 ? 396 LEU   A CB  1 
ATOM   2471 C  CG  . LEU   A 1 396 ? -9.79169  13.01384  19.78992 1.000 24.85561 ? 396 LEU   A CG  1 
ATOM   2472 C  CD1 . LEU   A 1 396 ? -10.73344 12.52045  20.87420 1.000 21.73748 ? 396 LEU   A CD1 1 
ATOM   2473 C  CD2 . LEU   A 1 396 ? -8.77404  13.98686  20.36776 1.000 25.56775 ? 396 LEU   A CD2 1 
ATOM   2474 N  N   . ASP   A 1 397 ? -9.60990  11.34705  15.98495 1.000 19.41159 ? 397 ASP   A N   1 
ATOM   2475 C  CA  . ASP   A 1 397 ? -10.05713 11.85865  14.69182 1.000 24.26793 ? 397 ASP   A CA  1 
ATOM   2476 C  C   . ASP   A 1 397 ? -11.23192 11.05395  14.15281 1.000 20.16394 ? 397 ASP   A C   1 
ATOM   2477 O  O   . ASP   A 1 397 ? -12.19323 11.62386  13.62270 1.000 20.08268 ? 397 ASP   A O   1 
ATOM   2478 C  CB  . ASP   A 1 397 ? -8.90480  11.84224  13.68664 1.000 21.38335 ? 397 ASP   A CB  1 
ATOM   2479 C  CG  . ASP   A 1 397 ? -7.88921  12.93539  13.94130 1.000 24.21691 ? 397 ASP   A CG  1 
ATOM   2480 O  OD1 . ASP   A 1 397 ? -8.25031  13.95258  14.56966 1.000 23.03152 ? 397 ASP   A OD1 1 
ATOM   2481 O  OD2 . ASP   A 1 397 ? -6.72998  12.77992  13.50353 1.000 24.42349 ? 397 ASP   A OD2 1 
ATOM   2482 N  N   . THR   A 1 398 ? -11.16425 9.72493   14.26416 1.000 20.81869 ? 398 THR   A N   1 
ATOM   2483 C  CA  . THR   A 1 398 ? -12.26890 8.88736   13.80823 1.000 17.89721 ? 398 THR   A CA  1 
ATOM   2484 C  C   . THR   A 1 398 ? -13.53823 9.18070   14.59652 1.000 16.76922 ? 398 THR   A C   1 
ATOM   2485 O  O   . THR   A 1 398 ? -14.62974 9.26974   14.02138 1.000 17.62009 ? 398 THR   A O   1 
ATOM   2486 C  CB  . THR   A 1 398 ? -11.89701 7.40930   13.93109 1.000 14.67672 ? 398 THR   A CB  1 
ATOM   2487 O  OG1 . THR   A 1 398 ? -10.64368 7.17072   13.27834 1.000 17.83912 ? 398 THR   A OG1 1 
ATOM   2488 C  CG2 . THR   A 1 398 ? -12.96711 6.53752   13.29131 1.000 17.38859 ? 398 THR   A CG2 1 
ATOM   2489 N  N   . LEU   A 1 399 ? -13.41086 9.33062   15.91804 1.000 16.21712 ? 399 LEU   A N   1 
ATOM   2490 C  CA  . LEU   A 1 399 ? -14.55292 9.68669   16.75360 1.000 14.78228 ? 399 LEU   A CA  1 
ATOM   2491 C  C   . LEU   A 1 399 ? -15.21908 10.96673  16.26812 1.000 19.06986 ? 399 LEU   A C   1 
ATOM   2492 O  O   . LEU   A 1 399 ? -16.45040 11.04514  16.18231 1.000 14.11969 ? 399 LEU   A O   1 
ATOM   2493 C  CB  . LEU   A 1 399 ? -14.09828 9.83918   18.20592 1.000 14.92859 ? 399 LEU   A CB  1 
ATOM   2494 C  CG  . LEU   A 1 399 ? -15.15451 10.21902  19.24127 1.000 13.99188 ? 399 LEU   A CG  1 
ATOM   2495 C  CD1 . LEU   A 1 399 ? -16.28891 9.21977   19.21623 1.000 12.99273 ? 399 LEU   A CD1 1 
ATOM   2496 C  CD2 . LEU   A 1 399 ? -14.53245 10.29014  20.62448 1.000 13.81946 ? 399 LEU   A CD2 1 
ATOM   2497 N  N   . GLU   A 1 400 ? -14.41804 11.97891  15.93480 1.000 17.54244 ? 400 GLU   A N   1 
ATOM   2498 C  CA  . GLU   A 1 400 ? -14.98102 13.24337  15.47969 1.000 18.75644 ? 400 GLU   A CA  1 
ATOM   2499 C  C   . GLU   A 1 400 ? -15.55980 13.12657  14.07447 1.000 19.61023 ? 400 GLU   A C   1 
ATOM   2500 O  O   . GLU   A 1 400 ? -16.56183 13.78127  13.76513 1.000 18.75054 ? 400 GLU   A O   1 
ATOM   2501 C  CB  . GLU   A 1 400 ? -13.91174 14.33356  15.56612 1.000 17.94904 ? 400 GLU   A CB  1 
ATOM   2502 C  CG  . GLU   A 1 400 ? -13.48884 14.60363  17.00957 1.000 21.06825 ? 400 GLU   A CG  1 
ATOM   2503 C  CD  . GLU   A 1 400 ? -12.24261 15.45911  17.13661 1.000 27.59077 ? 400 GLU   A CD  1 
ATOM   2504 O  OE1 . GLU   A 1 400 ? -11.93356 15.87657  18.27279 1.000 24.40667 ? 400 GLU   A OE1 1 
ATOM   2505 O  OE2 . GLU   A 1 400 ? -11.57029 15.70871  16.11402 1.000 24.43268 ? 400 GLU   A OE2 1 
ATOM   2506 N  N   . ASP   A 1 401 ? -14.96585 12.28810  13.22141 1.000 19.07425 ? 401 ASP   A N   1 
ATOM   2507 C  CA  . ASP   A 1 401 ? -15.56766 12.01312  11.91935 1.000 20.10601 ? 401 ASP   A CA  1 
ATOM   2508 C  C   . ASP   A 1 401 ? -16.90678 11.30293  12.07685 1.000 23.72540 ? 401 ASP   A C   1 
ATOM   2509 O  O   . ASP   A 1 401 ? -17.90342 11.68413  11.45139 1.000 19.00269 ? 401 ASP   A O   1 
ATOM   2510 C  CB  . ASP   A 1 401 ? -14.62010 11.17470  11.05907 1.000 20.16945 ? 401 ASP   A CB  1 
ATOM   2511 C  CG  . ASP   A 1 401 ? -13.40417 11.95156  10.59701 1.000 21.82924 ? 401 ASP   A CG  1 
ATOM   2512 O  OD1 . ASP   A 1 401 ? -13.34061 13.17248  10.85079 1.000 26.28142 ? 401 ASP   A OD1 1 
ATOM   2513 O  OD2 . ASP   A 1 401 ? -12.51465 11.33973  9.96959  1.000 26.95656 ? 401 ASP   A OD2 1 
ATOM   2514 N  N   . ASN   A 1 402 ? -16.94553 10.25848  12.90983 1.000 17.69603 ? 402 ASN   A N   1 
ATOM   2515 C  CA  . ASN   A 1 402 ? -18.18806 9.52031   13.11776 1.000 17.81838 ? 402 ASN   A CA  1 
ATOM   2516 C  C   . ASN   A 1 402 ? -19.25647 10.40245  13.75025 1.000 18.19229 ? 402 ASN   A C   1 
ATOM   2517 O  O   . ASN   A 1 402 ? -20.44355 10.28485  13.42194 1.000 17.03512 ? 402 ASN   A O   1 
ATOM   2518 C  CB  . ASN   A 1 402 ? -17.93029 8.28793   13.98482 1.000 14.17386 ? 402 ASN   A CB  1 
ATOM   2519 C  CG  . ASN   A 1 402 ? -17.12616 7.22546   13.26321 1.000 17.69529 ? 402 ASN   A CG  1 
ATOM   2520 O  OD1 . ASN   A 1 402 ? -17.02259 7.23582   12.03674 1.000 17.28746 ? 402 ASN   A OD1 1 
ATOM   2521 N  ND2 . ASN   A 1 402 ? -16.55819 6.29518   14.02206 1.000 15.67344 ? 402 ASN   A ND2 1 
ATOM   2522 N  N   . ARG   A 1 403 ? -18.85492 11.28296  14.67020 1.000 19.86677 ? 403 ARG   A N   1 
ATOM   2523 C  CA  . ARG   A 1 403 ? -19.79052 12.24998  15.23558 1.000 17.43470 ? 403 ARG   A CA  1 
ATOM   2524 C  C   . ARG   A 1 403 ? -20.37935 13.12953  14.14144 1.000 19.38349 ? 403 ARG   A C   1 
ATOM   2525 O  O   . ARG   A 1 403 ? -21.59846 13.32489  14.07017 1.000 19.41269 ? 403 ARG   A O   1 
ATOM   2526 C  CB  . ARG   A 1 403 ? -19.08202 13.09936  16.29490 1.000 17.23991 ? 403 ARG   A CB  1 
ATOM   2527 C  CG  . ARG   A 1 403 ? -19.99878 13.95203  17.16958 1.000 19.63528 ? 403 ARG   A CG  1 
ATOM   2528 C  CD  . ARG   A 1 403 ? -20.28894 15.31956  16.56337 1.000 18.85583 ? 403 ARG   A CD  1 
ATOM   2529 N  NE  . ARG   A 1 403 ? -21.11952 16.13043  17.44836 1.000 21.78634 ? 403 ARG   A NE  1 
ATOM   2530 C  CZ  . ARG   A 1 403 ? -21.73432 17.24958  17.08136 1.000 24.69950 ? 403 ARG   A CZ  1 
ATOM   2531 N  NH1 . ARG   A 1 403 ? -21.61937 17.69367  15.83749 1.000 22.35106 ? 403 ARG   A NH1 1 
ATOM   2532 N  NH2 . ARG   A 1 403 ? -22.46936 17.92170  17.95715 1.000 19.61266 ? 403 ARG   A NH2 1 
ATOM   2533 N  N   . GLU   A 1 404 ? -19.51706 13.66860  13.27675 1.000 21.98231 ? 404 GLU   A N   1 
ATOM   2534 C  CA  . GLU   A 1 404 ? -19.97955 14.49687  12.16902 1.000 26.94139 ? 404 GLU   A CA  1 
ATOM   2535 C  C   . GLU   A 1 404 ? -20.92055 13.72310  11.25472 1.000 24.86344 ? 404 GLU   A C   1 
ATOM   2536 O  O   . GLU   A 1 404 ? -21.89220 14.28332  10.73349 1.000 25.49839 ? 404 GLU   A O   1 
ATOM   2537 C  CB  . GLU   A 1 404 ? -18.77539 15.02479  11.38786 1.000 26.36786 ? 404 GLU   A CB  1 
ATOM   2538 C  CG  . GLU   A 1 404 ? -19.11301 15.77581  10.11261 1.000 34.58796 ? 404 GLU   A CG  1 
ATOM   2539 C  CD  . GLU   A 1 404 ? -17.87215 16.23506  9.37221  1.000 51.46755 ? 404 GLU   A CD  1 
ATOM   2540 O  OE1 . GLU   A 1 404 ? -16.82236 15.57237  9.50670  1.000 51.42366 ? 404 GLU   A OE1 1 
ATOM   2541 O  OE2 . GLU   A 1 404 ? -17.94674 17.25689  8.65965  1.000 60.73848 ? 404 GLU   A OE2 1 
ATOM   2542 N  N   . TRP   A 1 405 ? -20.65937 12.42920  11.05966 1.000 24.95878 ? 405 TRP   A N   1 
ATOM   2543 C  CA  . TRP   A 1 405 ? -21.48618 11.64484  10.14897 1.000 18.72801 ? 405 TRP   A CA  1 
ATOM   2544 C  C   . TRP   A 1 405 ? -22.88403 11.42876  10.71643 1.000 21.99048 ? 405 TRP   A C   1 
ATOM   2545 O  O   . TRP   A 1 405 ? -23.88426 11.68470  10.03591 1.000 24.19475 ? 405 TRP   A O   1 
ATOM   2546 C  CB  . TRP   A 1 405 ? -20.81843 10.30628  9.84210  1.000 18.53897 ? 405 TRP   A CB  1 
ATOM   2547 C  CG  . TRP   A 1 405 ? -21.60131 9.49941   8.86057  1.000 19.95600 ? 405 TRP   A CG  1 
ATOM   2548 C  CD1 . TRP   A 1 405 ? -21.49827 9.53723   7.50018  1.000 18.25495 ? 405 TRP   A CD1 1 
ATOM   2549 C  CD2 . TRP   A 1 405 ? -22.62735 8.54672   9.15920  1.000 18.98432 ? 405 TRP   A CD2 1 
ATOM   2550 N  NE1 . TRP   A 1 405 ? -22.39055 8.65996   6.93368  1.000 15.55704 ? 405 TRP   A NE1 1 
ATOM   2551 C  CE2 . TRP   A 1 405 ? -23.09654 8.03994   7.93087  1.000 18.40586 ? 405 TRP   A CE2 1 
ATOM   2552 C  CE3 . TRP   A 1 405 ? -23.19186 8.06916   10.34647 1.000 19.42647 ? 405 TRP   A CE3 1 
ATOM   2553 C  CZ2 . TRP   A 1 405 ? -24.10264 7.07953   7.85550  1.000 17.21997 ? 405 TRP   A CZ2 1 
ATOM   2554 C  CZ3 . TRP   A 1 405 ? -24.19036 7.11608   10.26983 1.000 19.03980 ? 405 TRP   A CZ3 1 
ATOM   2555 C  CH2 . TRP   A 1 405 ? -24.63538 6.63124   9.03279  1.000 19.28579 ? 405 TRP   A CH2 1 
ATOM   2556 N  N   . TYR   A 1 406 ? -22.97500 10.94079  11.95778 1.000 19.78004 ? 406 TYR   A N   1 
ATOM   2557 C  CA  . TYR   A 1 406 ? -24.28169 10.78464  12.59136 1.000 23.50237 ? 406 TYR   A CA  1 
ATOM   2558 C  C   . TYR   A 1 406 ? -25.01395 12.11702  12.67087 1.000 20.50579 ? 406 TYR   A C   1 
ATOM   2559 O  O   . TYR   A 1 406 ? -26.24146 12.17112  12.52809 1.000 20.16901 ? 406 TYR   A O   1 
ATOM   2560 C  CB  . TYR   A 1 406 ? -24.12928 10.17800  13.98658 1.000 19.06338 ? 406 TYR   A CB  1 
ATOM   2561 C  CG  . TYR   A 1 406 ? -24.34440 8.68145   14.04095 1.000 20.50516 ? 406 TYR   A CG  1 
ATOM   2562 C  CD1 . TYR   A 1 406 ? -25.61984 8.13969   13.93114 1.000 18.07049 ? 406 TYR   A CD1 1 
ATOM   2563 C  CD2 . TYR   A 1 406 ? -23.27627 7.81156   14.21760 1.000 15.70057 ? 406 TYR   A CD2 1 
ATOM   2564 C  CE1 . TYR   A 1 406 ? -25.82317 6.77256   13.98474 1.000 17.81243 ? 406 TYR   A CE1 1 
ATOM   2565 C  CE2 . TYR   A 1 406 ? -23.46976 6.44336   14.27187 1.000 16.82657 ? 406 TYR   A CE2 1 
ATOM   2566 C  CZ  . TYR   A 1 406 ? -24.74379 5.92976   14.15598 1.000 18.97856 ? 406 TYR   A CZ  1 
ATOM   2567 O  OH  . TYR   A 1 406 ? -24.93571 4.56853   14.21158 1.000 15.81144 ? 406 TYR   A OH  1 
ATOM   2568 N  N   . GLN   A 1 407 ? -24.27325 13.20358  12.89849 1.000 16.56935 ? 407 GLN   A N   1 
ATOM   2569 C  CA  . GLN   A 1 407 ? -24.87864 14.53014  12.90925 1.000 26.38672 ? 407 GLN   A CA  1 
ATOM   2570 C  C   . GLN   A 1 407 ? -25.48906 14.87098  11.55515 1.000 27.29715 ? 407 GLN   A C   1 
ATOM   2571 O  O   . GLN   A 1 407 ? -26.60629 15.39690  11.48426 1.000 31.11053 ? 407 GLN   A O   1 
ATOM   2572 C  CB  . GLN   A 1 407 ? -23.83273 15.57219  13.30309 1.000 25.19337 ? 407 GLN   A CB  1 
ATOM   2573 C  CG  . GLN   A 1 407 ? -24.32585 17.00300  13.23638 1.000 29.34274 ? 407 GLN   A CG  1 
ATOM   2574 C  CD  . GLN   A 1 407 ? -25.43391 17.28259  14.22993 1.000 29.72667 ? 407 GLN   A CD  1 
ATOM   2575 O  OE1 . GLN   A 1 407 ? -25.49182 16.67821  15.30081 1.000 33.81526 ? 407 GLN   A OE1 1 
ATOM   2576 N  NE2 . GLN   A 1 407 ? -26.32081 18.20428  13.88035 1.000 34.50036 ? 407 GLN   A NE2 1 
ATOM   2577 N  N   . SER   A 1 408 ? -24.77727 14.56387  10.46762 1.000 25.15727 ? 408 SER   A N   1 
ATOM   2578 C  CA  . SER   A 1 408 ? -25.23472 14.91512  9.12790  1.000 24.42534 ? 408 SER   A CA  1 
ATOM   2579 C  C   . SER   A 1 408 ? -26.46333 14.13001  8.68533  1.000 26.82978 ? 408 SER   A C   1 
ATOM   2580 O  O   . SER   A 1 408 ? -27.06923 14.49055  7.67072  1.000 30.08578 ? 408 SER   A O   1 
ATOM   2581 C  CB  . SER   A 1 408 ? -24.10402 14.70393  8.11800  1.000 22.93466 ? 408 SER   A CB  1 
ATOM   2582 O  OG  . SER   A 1 408 ? -23.83190 13.32529  7.93719  1.000 25.21756 ? 408 SER   A OG  1 
ATOM   2583 N  N   . THR   A 1 409 ? -26.84146 13.07542  9.40417  1.000 29.27759 ? 409 THR   A N   1 
ATOM   2584 C  CA  . THR   A 1 409 ? -28.01999 12.28568  9.07303  1.000 32.44064 ? 409 THR   A CA  1 
ATOM   2585 C  C   . THR   A 1 409 ? -29.28136 12.79337  9.75928  1.000 38.49147 ? 409 THR   A C   1 
ATOM   2586 O  O   . THR   A 1 409 ? -30.32996 12.14798  9.65998  1.000 44.37889 ? 409 THR   A O   1 
ATOM   2587 C  CB  . THR   A 1 409 ? -27.79680 10.81702  9.44313  1.000 32.53196 ? 409 THR   A CB  1 
ATOM   2588 O  OG1 . THR   A 1 409 ? -27.70921 10.69148  10.86740 1.000 32.22211 ? 409 THR   A OG1 1 
ATOM   2589 C  CG2 . THR   A 1 409 ? -26.51475 10.29876  8.81682  1.000 24.05375 ? 409 THR   A CG2 1 
ATOM   2590 N  N   . ILE   A 1 410 ? -29.20514 13.92666  10.44755 1.000 37.62243 ? 410 ILE   A N   1 
ATOM   2591 C  CA  . ILE   A 1 410 ? -30.33425 14.44821  11.21325 1.000 40.49544 ? 410 ILE   A CA  1 
ATOM   2592 C  C   . ILE   A 1 410 ? -31.10385 15.48360  10.39512 1.000 45.31891 ? 410 ILE   A C   1 
ATOM   2593 O  O   . ILE   A 1 410 ? -32.34322 15.43914  10.38132 1.000 50.16978 ? 410 ILE   A O   1 
ATOM   2594 C  CB  . ILE   A 1 410 ? -29.86271 15.01592  12.56234 1.000 38.84729 ? 410 ILE   A CB  1 
ATOM   2595 C  CG1 . ILE   A 1 410 ? -29.26716 13.89466  13.41747 1.000 33.77481 ? 410 ILE   A CG1 1 
ATOM   2596 C  CG2 . ILE   A 1 410 ? -31.00908 15.68647  13.29335 1.000 28.74254 ? 410 ILE   A CG2 1 
ATOM   2597 C  CD1 . ILE   A 1 410 ? -28.57283 14.37446  14.67049 1.000 32.45211 ? 410 ILE   A CD1 1 
ATOM   2598 N  N   . PRO   A 1 411 ? -30.44161 16.43504  9.70138  1.000 45.21909 ? 411 PRO   A N   1 
ATOM   2599 C  CA  . PRO   A 1 411 ? -31.24578 17.31202  8.83879  1.000 49.67658 ? 411 PRO   A CA  1 
ATOM   2600 C  C   . PRO   A 1 411 ? -31.95833 16.55907  7.71664  1.000 57.48304 ? 411 PRO   A C   1 
ATOM   2601 O  O   . PRO   A 1 411 ? -32.93425 17.07829  7.17446  1.000 61.23493 ? 411 PRO   A O   1 
ATOM   2602 C  CB  . PRO   A 1 411 ? -30.21043 18.28107  8.25841  1.000 47.47535 ? 411 PRO   A CB  1 
ATOM   2603 C  CG  . PRO   A 1 411 ? -29.10635 18.28907  9.24636  1.000 43.77960 ? 411 PRO   A CG  1 
ATOM   2604 C  CD  . PRO   A 1 411 ? -29.04007 16.89050  9.77706  1.000 37.51733 ? 411 PRO   A CD  1 
ATOM   2605 N  N   . ASP   B 1 90  ? -44.12144 -12.90448 82.12635 1.000 65.80519 ? 90  ASP   B N   1 
ATOM   2606 C  CA  . ASP   B 1 90  ? -44.57579 -12.28766 83.37368 1.000 71.40774 ? 90  ASP   B CA  1 
ATOM   2607 C  C   . ASP   B 1 90  ? -43.68456 -11.10202 83.71017 1.000 68.07476 ? 90  ASP   B C   1 
ATOM   2608 O  O   . ASP   B 1 90  ? -44.02879 -9.93201  83.47081 1.000 65.80541 ? 90  ASP   B O   1 
ATOM   2609 C  CB  . ASP   B 1 90  ? -44.57904 -13.31481 84.53508 1.000 78.59936 ? 90  ASP   B CB  1 
ATOM   2610 C  CG  . ASP   B 1 90  ? -43.27367 -14.06982 84.64553 1.000 81.77418 ? 90  ASP   B CG  1 
ATOM   2611 O  OD1 . ASP   B 1 90  ? -43.07286 -14.77919 85.62735 1.000 80.20070 ? 90  ASP   B OD1 1 
ATOM   2612 O  OD2 . ASP   B 1 90  ? -42.42832 -13.93449 83.77154 1.000 85.98564 ? 90  ASP   B OD2 1 
ATOM   2613 N  N   . VAL   B 1 91  ? -42.53253 -11.41754 84.30193 1.000 68.19721 ? 91  VAL   B N   1 
ATOM   2614 C  CA  . VAL   B 1 91  ? -41.49982 -10.46929 84.68617 1.000 65.45272 ? 91  VAL   B CA  1 
ATOM   2615 C  C   . VAL   B 1 91  ? -40.74972 -9.94206  83.47199 1.000 62.13611 ? 91  VAL   B C   1 
ATOM   2616 O  O   . VAL   B 1 91  ? -40.12255 -8.88083  83.55295 1.000 50.42110 ? 91  VAL   B O   1 
ATOM   2617 C  CB  . VAL   B 1 91  ? -40.60414 -11.20735 85.70911 1.000 65.35558 ? 91  VAL   B CB  1 
ATOM   2618 C  CG1 . VAL   B 1 91  ? -39.20998 -10.60624 85.78864 1.000 59.13291 ? 91  VAL   B CG1 1 
ATOM   2619 C  CG2 . VAL   B 1 91  ? -41.28740 -11.22090 87.07515 1.000 64.40078 ? 91  VAL   B CG2 1 
ATOM   2620 N  N   . LEU   B 1 92  ? -40.80360 -10.65796 82.34226 1.000 59.41068 ? 92  LEU   B N   1 
ATOM   2621 C  CA  . LEU   B 1 92  ? -40.42639 -10.07530 81.05886 1.000 51.18619 ? 92  LEU   B CA  1 
ATOM   2622 C  C   . LEU   B 1 92  ? -41.01401 -8.67794  80.91489 1.000 57.59283 ? 92  LEU   B C   1 
ATOM   2623 O  O   . LEU   B 1 92  ? -40.31802 -7.73100  80.53516 1.000 52.74616 ? 92  LEU   B O   1 
ATOM   2624 C  CB  . LEU   B 1 92  ? -40.90873 -10.99032 79.92579 1.000 51.59192 ? 92  LEU   B CB  1 
ATOM   2625 C  CG  . LEU   B 1 92  ? -40.64631 -10.52583 78.49527 1.000 54.65986 ? 92  LEU   B CG  1 
ATOM   2626 C  CD1 . LEU   B 1 92  ? -39.17424 -10.20734 78.30276 1.000 46.96584 ? 92  LEU   B CD1 1 
ATOM   2627 C  CD2 . LEU   B 1 92  ? -41.11469 -11.57374 77.49683 1.000 43.55170 ? 92  LEU   B CD2 1 
ATOM   2628 N  N   . ALA   B 1 93  ? -42.29382 -8.53006  81.27277 1.000 55.85932 ? 93  ALA   B N   1 
ATOM   2629 C  CA  . ALA   B 1 93  ? -42.94986 -7.22814  81.19731 1.000 57.43135 ? 93  ALA   B CA  1 
ATOM   2630 C  C   . ALA   B 1 93  ? -42.22307 -6.17627  82.02854 1.000 57.84290 ? 93  ALA   B C   1 
ATOM   2631 O  O   . ALA   B 1 93  ? -42.03705 -5.04266  81.57380 1.000 59.07446 ? 93  ALA   B O   1 
ATOM   2632 C  CB  . ALA   B 1 93  ? -44.40920 -7.34578  81.64239 1.000 57.18093 ? 93  ALA   B CB  1 
ATOM   2633 N  N   . LYS   B 1 94  ? -41.79533 -6.52772  83.24499 1.000 55.29507 ? 94  LYS   B N   1 
ATOM   2634 C  CA  . LYS   B 1 94  ? -41.12547 -5.53869  84.08620 1.000 56.04436 ? 94  LYS   B CA  1 
ATOM   2635 C  C   . LYS   B 1 94  ? -39.77045 -5.14893  83.50197 1.000 54.97073 ? 94  LYS   B C   1 
ATOM   2636 O  O   . LYS   B 1 94  ? -39.43400 -3.96002  83.43884 1.000 55.60380 ? 94  LYS   B O   1 
ATOM   2637 C  CB  . LYS   B 1 94  ? -40.97946 -6.06251  85.51847 1.000 59.13886 ? 94  LYS   B CB  1 
ATOM   2638 C  CG  . LYS   B 1 94  ? -40.82449 -4.96530  86.57890 1.000 63.27611 ? 94  LYS   B CG  1 
ATOM   2639 C  CD  . LYS   B 1 94  ? -39.48822 -4.23482  86.50308 1.000 64.05816 ? 94  LYS   B CD  1 
ATOM   2640 C  CE  . LYS   B 1 94  ? -39.54200 -2.89653  87.21478 1.000 65.14315 ? 94  LYS   B CE  1 
ATOM   2641 N  NZ  . LYS   B 1 94  ? -38.52978 -1.94760  86.66811 1.000 62.32270 ? 94  LYS   B NZ  1 
ATOM   2642 N  N   . GLU   B 1 95  ? -38.97663 -6.13514  83.06939 1.000 56.26349 ? 95  GLU   B N   1 
ATOM   2643 C  CA  . GLU   B 1 95  ? -37.67626 -5.82510  82.47896 1.000 52.28390 ? 95  GLU   B CA  1 
ATOM   2644 C  C   . GLU   B 1 95  ? -37.82178 -4.89413  81.28428 1.000 49.52702 ? 95  GLU   B C   1 
ATOM   2645 O  O   . GLU   B 1 95  ? -37.01627 -3.97273  81.10346 1.000 46.53589 ? 95  GLU   B O   1 
ATOM   2646 C  CB  . GLU   B 1 95  ? -36.95484 -7.10855  82.06106 1.000 52.93292 ? 95  GLU   B CB  1 
ATOM   2647 C  CG  . GLU   B 1 95  ? -36.60000 -8.04960  83.20054 1.000 56.03852 ? 95  GLU   B CG  1 
ATOM   2648 C  CD  . GLU   B 1 95  ? -35.53566 -7.49152  84.12926 1.000 53.77767 ? 95  GLU   B CD  1 
ATOM   2649 O  OE1 . GLU   B 1 95  ? -34.95498 -6.42868  83.82205 1.000 53.70333 ? 95  GLU   B OE1 1 
ATOM   2650 O  OE2 . GLU   B 1 95  ? -35.27877 -8.12156  85.17489 1.000 58.27646 ? 95  GLU   B OE2 1 
ATOM   2651 N  N   . LEU   B 1 96  ? -38.85753 -5.10558  80.46981 1.000 52.14055 ? 96  LEU   B N   1 
ATOM   2652 C  CA  . LEU   B 1 96  ? -39.04943 -4.29278  79.27522 1.000 50.66054 ? 96  LEU   B CA  1 
ATOM   2653 C  C   . LEU   B 1 96  ? -39.37459 -2.83848  79.59007 1.000 51.12750 ? 96  LEU   B C   1 
ATOM   2654 O  O   . LEU   B 1 96  ? -39.14322 -1.97427  78.73844 1.000 46.21695 ? 96  LEU   B O   1 
ATOM   2655 C  CB  . LEU   B 1 96  ? -40.15118 -4.90450  78.40582 1.000 44.01837 ? 96  LEU   B CB  1 
ATOM   2656 C  CG  . LEU   B 1 96  ? -39.78957 -6.26262  77.80343 1.000 48.89607 ? 96  LEU   B CG  1 
ATOM   2657 C  CD1 . LEU   B 1 96  ? -40.97443 -6.86636  77.06925 1.000 47.84264 ? 96  LEU   B CD1 1 
ATOM   2658 C  CD2 . LEU   B 1 96  ? -38.58481 -6.13133  76.88438 1.000 42.47800 ? 96  LEU   B CD2 1 
ATOM   2659 N  N   . GLU   B 1 97  ? -39.88903 -2.54470  80.78808 1.000 51.36664 ? 97  GLU   B N   1 
ATOM   2660 C  CA  . GLU   B 1 97  ? -40.24236 -1.17233  81.14891 1.000 46.62948 ? 97  GLU   B CA  1 
ATOM   2661 C  C   . GLU   B 1 97  ? -39.05205 -0.23455  81.15933 1.000 46.78044 ? 97  GLU   B C   1 
ATOM   2662 O  O   . GLU   B 1 97  ? -39.25030 0.98231   81.26249 1.000 51.70616 ? 97  GLU   B O   1 
ATOM   2663 C  CB  . GLU   B 1 97  ? -40.92116 -1.14744  82.51818 1.000 55.97703 ? 97  GLU   B CB  1 
ATOM   2664 C  CG  . GLU   B 1 97  ? -42.13872 -2.02398  82.61270 1.000 55.14029 ? 97  GLU   B CG  1 
ATOM   2665 C  CD  . GLU   B 1 97  ? -42.78276 -1.96780  83.97682 1.000 60.45267 ? 97  GLU   B CD  1 
ATOM   2666 O  OE1 . GLU   B 1 97  ? -42.40079 -1.09449  84.78509 1.000 62.53513 ? 97  GLU   B OE1 1 
ATOM   2667 O  OE2 . GLU   B 1 97  ? -43.66895 -2.80440  84.24199 1.000 58.44887 ? 97  GLU   B OE2 1 
ATOM   2668 N  N   . ASP   B 1 98  ? -37.83550 -0.76508  81.09120 1.000 51.43867 ? 98  ASP   B N   1 
ATOM   2669 C  CA  . ASP   B 1 98  ? -36.62198 0.02823   81.01816 1.000 50.82613 ? 98  ASP   B CA  1 
ATOM   2670 C  C   . ASP   B 1 98  ? -36.07209 0.11277   79.59475 1.000 45.43999 ? 98  ASP   B C   1 
ATOM   2671 O  O   . ASP   B 1 98  ? -34.89946 0.47026   79.41052 1.000 40.32225 ? 98  ASP   B O   1 
ATOM   2672 C  CB  . ASP   B 1 98  ? -35.57805 -0.51641  81.98871 1.000 52.20515 ? 98  ASP   B CB  1 
ATOM   2673 C  CG  . ASP   B 1 98  ? -36.14800 -0.75759  83.39418 1.000 55.49757 ? 98  ASP   B CG  1 
ATOM   2674 O  OD1 . ASP   B 1 98  ? -36.65517 0.20481   83.98052 1.000 55.03096 ? 98  ASP   B OD1 1 
ATOM   2675 O  OD2 . ASP   B 1 98  ? -36.03339 -1.88212  83.93965 1.000 55.53935 ? 98  ASP   B OD2 1 
ATOM   2676 N  N   . VAL   B 1 99  ? -36.93113 -0.10001  78.58974 1.000 44.80716 ? 99  VAL   B N   1 
ATOM   2677 C  CA  . VAL   B 1 99  ? -36.53278 -0.12079  77.18794 1.000 40.18839 ? 99  VAL   B CA  1 
ATOM   2678 C  C   . VAL   B 1 99  ? -35.87863 1.18099   76.75233 1.000 44.79542 ? 99  VAL   B C   1 
ATOM   2679 O  O   . VAL   B 1 99  ? -35.13813 1.19562   75.76482 1.000 41.72185 ? 99  VAL   B O   1 
ATOM   2680 C  CB  . VAL   B 1 99  ? -37.76431 -0.44866  76.31149 1.000 42.11139 ? 99  VAL   B CB  1 
ATOM   2681 C  CG1 . VAL   B 1 99  ? -38.71989 0.72863   76.25540 1.000 41.23049 ? 99  VAL   B CG1 1 
ATOM   2682 C  CG2 . VAL   B 1 99  ? -37.34414 -0.88661  74.90569 1.000 43.47705 ? 99  VAL   B CG2 1 
ATOM   2683 N  N   . ASN   B 1 100 ? -36.10750 2.27309   77.48000 1.000 33.72736 ? 100 ASN   B N   1 
ATOM   2684 C  CA  . ASN   B 1 100 ? -35.56415 3.57267   77.12037 1.000 37.51901 ? 100 ASN   B CA  1 
ATOM   2685 C  C   . ASN   B 1 100 ? -34.27721 3.90483   77.86019 1.000 38.14842 ? 100 ASN   B C   1 
ATOM   2686 O  O   . ASN   B 1 100 ? -33.79244 5.03547   77.74798 1.000 37.24844 ? 100 ASN   B O   1 
ATOM   2687 C  CB  . ASN   B 1 100 ? -36.59912 4.66947   77.38141 1.000 43.49091 ? 100 ASN   B CB  1 
ATOM   2688 C  CG  . ASN   B 1 100 ? -37.83154 4.52642   76.51655 1.000 49.16305 ? 100 ASN   B CG  1 
ATOM   2689 O  OD1 . ASN   B 1 100 ? -37.84885 3.74599   75.56519 1.000 45.88105 ? 100 ASN   B OD1 1 
ATOM   2690 N  ND2 . ASN   B 1 100 ? -38.86566 5.29810   76.82865 1.000 43.70459 ? 100 ASN   B ND2 1 
ATOM   2691 N  N   . LYS   B 1 101 ? -33.70983 2.96422   78.61265 1.000 41.21728 ? 101 LYS   B N   1 
ATOM   2692 C  CA  . LYS   B 1 101 ? -32.56103 3.26624   79.45445 1.000 39.84688 ? 101 LYS   B CA  1 
ATOM   2693 C  C   . LYS   B 1 101 ? -31.31406 2.50650   79.01833 1.000 35.04738 ? 101 LYS   B C   1 
ATOM   2694 O  O   . LYS   B 1 101 ? -31.36599 1.31590   78.68473 1.000 32.04597 ? 101 LYS   B O   1 
ATOM   2695 C  CB  . LYS   B 1 101 ? -32.87158 2.98994   80.92996 1.000 41.61901 ? 101 LYS   B CB  1 
ATOM   2696 C  CG  . LYS   B 1 101 ? -33.91617 3.95564   81.47462 1.000 44.88784 ? 101 LYS   B CG  1 
ATOM   2697 C  CD  . LYS   B 1 101 ? -34.16192 3.76887   82.95898 1.000 51.83044 ? 101 LYS   B CD  1 
ATOM   2698 C  CE  . LYS   B 1 101 ? -35.02626 2.58139   83.22555 1.000 53.30664 ? 101 LYS   B CE  1 
ATOM   2699 N  NZ  . LYS   B 1 101 ? -36.49257 2.88975   83.39747 1.000 50.84717 ? 101 LYS   B NZ  1 
ATOM   2700 N  N   . TRP   B 1 102 ? -30.20463 3.23852   78.98964 1.000 31.24598 ? 102 TRP   B N   1 
ATOM   2701 C  CA  . TRP   B 1 102 ? -28.88193 2.65892   78.81749 1.000 34.93074 ? 102 TRP   B CA  1 
ATOM   2702 C  C   . TRP   B 1 102 ? -28.61618 1.65427   79.92927 1.000 42.95161 ? 102 TRP   B C   1 
ATOM   2703 O  O   . TRP   B 1 102 ? -28.60218 2.01374   81.11077 1.000 43.88747 ? 102 TRP   B O   1 
ATOM   2704 C  CB  . TRP   B 1 102 ? -27.84028 3.77758   78.84619 1.000 36.81265 ? 102 TRP   B CB  1 
ATOM   2705 C  CG  . TRP   B 1 102 ? -26.64475 3.58723   77.96209 1.000 37.29065 ? 102 TRP   B CG  1 
ATOM   2706 C  CD1 . TRP   B 1 102 ? -25.34468 3.46307   78.35973 1.000 31.71623 ? 102 TRP   B CD1 1 
ATOM   2707 C  CD2 . TRP   B 1 102 ? -26.63201 3.53863   76.53021 1.000 34.78384 ? 102 TRP   B CD2 1 
ATOM   2708 N  NE1 . TRP   B 1 102 ? -24.52538 3.32710   77.26560 1.000 31.37156 ? 102 TRP   B NE1 1 
ATOM   2709 C  CE2 . TRP   B 1 102 ? -25.29115 3.36934   76.13022 1.000 31.30507 ? 102 TRP   B CE2 1 
ATOM   2710 C  CE3 . TRP   B 1 102 ? -27.62443 3.61347   75.54819 1.000 32.15078 ? 102 TRP   B CE3 1 
ATOM   2711 C  CZ2 . TRP   B 1 102 ? -24.91796 3.27385   74.79118 1.000 29.77859 ? 102 TRP   B CZ2 1 
ATOM   2712 C  CZ3 . TRP   B 1 102 ? -27.25190 3.51811   74.21919 1.000 30.19608 ? 102 TRP   B CZ3 1 
ATOM   2713 C  CH2 . TRP   B 1 102 ? -25.91051 3.35001   73.85316 1.000 29.60472 ? 102 TRP   B CH2 1 
ATOM   2714 N  N   . GLY   B 1 103 ? -28.40731 0.39880   79.55925 1.000 41.41937 ? 103 GLY   B N   1 
ATOM   2715 C  CA  . GLY   B 1 103 ? -28.19017 -0.64649  80.53422 1.000 36.48249 ? 103 GLY   B CA  1 
ATOM   2716 C  C   . GLY   B 1 103 ? -29.35256 -1.58791  80.74569 1.000 40.23853 ? 103 GLY   B C   1 
ATOM   2717 O  O   . GLY   B 1 103 ? -29.42228 -2.22436  81.80430 1.000 43.95884 ? 103 GLY   B O   1 
ATOM   2718 N  N   . LEU   B 1 104 ? -30.27803 -1.66682  79.79078 1.000 36.43532 ? 104 LEU   B N   1 
ATOM   2719 C  CA  . LEU   B 1 104 ? -31.29501 -2.70723  79.76923 1.000 38.50391 ? 104 LEU   B CA  1 
ATOM   2720 C  C   . LEU   B 1 104 ? -30.66626 -4.06782  80.03628 1.000 39.26975 ? 104 LEU   B C   1 
ATOM   2721 O  O   . LEU   B 1 104 ? -29.57712 -4.36981  79.54298 1.000 39.34881 ? 104 LEU   B O   1 
ATOM   2722 C  CB  . LEU   B 1 104 ? -31.98885 -2.70607  78.40482 1.000 33.58714 ? 104 LEU   B CB  1 
ATOM   2723 C  CG  . LEU   B 1 104 ? -33.25489 -3.52512  78.19442 1.000 37.45777 ? 104 LEU   B CG  1 
ATOM   2724 C  CD1 . LEU   B 1 104 ? -34.48265 -2.71671  78.55126 1.000 42.02619 ? 104 LEU   B CD1 1 
ATOM   2725 C  CD2 . LEU   B 1 104 ? -33.32419 -4.01554  76.75361 1.000 35.54963 ? 104 LEU   B CD2 1 
ATOM   2726 N  N   . HIS   B 1 105 ? -31.35282 -4.88794  80.83280 1.000 40.37980 ? 105 HIS   B N   1 
ATOM   2727 C  CA  . HIS   B 1 105 ? -30.87618 -6.23814  81.13548 1.000 39.15306 ? 105 HIS   B CA  1 
ATOM   2728 C  C   . HIS   B 1 105 ? -31.21730 -7.15611  79.96058 1.000 37.33711 ? 105 HIS   B C   1 
ATOM   2729 O  O   . HIS   B 1 105 ? -32.10584 -8.00834  80.02113 1.000 37.92038 ? 105 HIS   B O   1 
ATOM   2730 C  CB  . HIS   B 1 105 ? -31.47753 -6.74241  82.44007 1.000 41.63446 ? 105 HIS   B CB  1 
ATOM   2731 C  CG  . HIS   B 1 105 ? -31.13028 -5.90463  83.63181 1.000 44.18241 ? 105 HIS   B CG  1 
ATOM   2732 N  ND1 . HIS   B 1 105 ? -32.00157 -5.70948  84.68177 1.000 49.83563 ? 105 HIS   B ND1 1 
ATOM   2733 C  CD2 . HIS   B 1 105 ? -30.00704 -5.21463  83.94235 1.000 47.95375 ? 105 HIS   B CD2 1 
ATOM   2734 C  CE1 . HIS   B 1 105 ? -31.43156 -4.93395  85.58660 1.000 47.75537 ? 105 HIS   B CE1 1 
ATOM   2735 N  NE2 . HIS   B 1 105 ? -30.22078 -4.61970  85.16232 1.000 47.21025 ? 105 HIS   B NE2 1 
ATOM   2736 N  N   . VAL   B 1 106 ? -30.47390 -6.96511  78.86673 1.000 35.90832 ? 106 VAL   B N   1 
ATOM   2737 C  CA  . VAL   B 1 106 ? -30.77608 -7.67380  77.62568 1.000 32.29029 ? 106 VAL   B CA  1 
ATOM   2738 C  C   . VAL   B 1 106 ? -30.58524 -9.17615  77.78864 1.000 31.93750 ? 106 VAL   B C   1 
ATOM   2739 O  O   . VAL   B 1 106 ? -31.32265 -9.97083  77.19180 1.000 33.72464 ? 106 VAL   B O   1 
ATOM   2740 C  CB  . VAL   B 1 106 ? -29.92304 -7.11006  76.46868 1.000 28.92390 ? 106 VAL   B CB  1 
ATOM   2741 C  CG1 . VAL   B 1 106 ? -28.43748 -7.33579  76.72367 1.000 27.07589 ? 106 VAL   B CG1 1 
ATOM   2742 C  CG2 . VAL   B 1 106 ? -30.34756 -7.72217  75.13974 1.000 29.16424 ? 106 VAL   B CG2 1 
ATOM   2743 N  N   . PHE   B 1 107 ? -29.61452 -9.59430  78.60448 1.000 31.82741 ? 107 PHE   B N   1 
ATOM   2744 C  CA  . PHE   B 1 107 ? -29.37377 -11.02218 78.78332 1.000 26.72899 ? 107 PHE   B CA  1 
ATOM   2745 C  C   . PHE   B 1 107 ? -30.50255 -11.67698 79.56840 1.000 32.48710 ? 107 PHE   B C   1 
ATOM   2746 O  O   . PHE   B 1 107 ? -30.91682 -12.79831 79.25087 1.000 28.65871 ? 107 PHE   B O   1 
ATOM   2747 C  CB  . PHE   B 1 107 ? -28.02724 -11.24436 79.46916 1.000 28.34964 ? 107 PHE   B CB  1 
ATOM   2748 C  CG  . PHE   B 1 107 ? -26.84989 -10.92453 78.59539 1.000 26.53767 ? 107 PHE   B CG  1 
ATOM   2749 C  CD1 . PHE   B 1 107 ? -26.53092 -11.73872 77.52126 1.000 21.23991 ? 107 PHE   B CD1 1 
ATOM   2750 C  CD2 . PHE   B 1 107 ? -26.06761 -9.80816  78.84001 1.000 25.03614 ? 107 PHE   B CD2 1 
ATOM   2751 C  CE1 . PHE   B 1 107 ? -25.45150 -11.44932 76.70993 1.000 26.68092 ? 107 PHE   B CE1 1 
ATOM   2752 C  CE2 . PHE   B 1 107 ? -24.98545 -9.51342  78.03235 1.000 30.36767 ? 107 PHE   B CE2 1 
ATOM   2753 C  CZ  . PHE   B 1 107 ? -24.67733 -10.33563 76.96564 1.000 25.87709 ? 107 PHE   B CZ  1 
ATOM   2754 N  N   . ARG   B 1 108 ? -31.00826 -10.99470 80.59838 1.000 34.27941 ? 108 ARG   B N   1 
ATOM   2755 C  CA  . ARG   B 1 108 ? -32.21468 -11.45777 81.27583 1.000 39.71954 ? 108 ARG   B CA  1 
ATOM   2756 C  C   . ARG   B 1 108 ? -33.37889 -11.55487 80.30072 1.000 37.34547 ? 108 ARG   B C   1 
ATOM   2757 O  O   . ARG   B 1 108 ? -34.06299 -12.58241 80.22755 1.000 36.55429 ? 108 ARG   B O   1 
ATOM   2758 C  CB  . ARG   B 1 108 ? -32.56943 -10.51111 82.42114 1.000 45.22933 ? 108 ARG   B CB  1 
ATOM   2759 C  CG  . ARG   B 1 108 ? -32.28944 -11.03691 83.81408 1.000 50.89943 ? 108 ARG   B CG  1 
ATOM   2760 C  CD  . ARG   B 1 108 ? -33.40220 -10.59343 84.74749 1.000 59.64518 ? 108 ARG   B CD  1 
ATOM   2761 N  NE  . ARG   B 1 108 ? -33.00971 -10.58570 86.15239 1.000 72.32353 ? 108 ARG   B NE  1 
ATOM   2762 C  CZ  . ARG   B 1 108 ? -32.60729 -9.50069  86.80615 1.000 72.55956 ? 108 ARG   B CZ  1 
ATOM   2763 N  NH1 . ARG   B 1 108 ? -32.53817 -8.33376  86.17938 1.000 68.65847 ? 108 ARG   B NH1 1 
ATOM   2764 N  NH2 . ARG   B 1 108 ? -32.27271 -9.58162  88.08629 1.000 70.46628 ? 108 ARG   B NH2 1 
ATOM   2765 N  N   . ILE   B 1 109 ? -33.61498 -10.48156 79.54253 1.000 34.91456 ? 109 ILE   B N   1 
ATOM   2766 C  CA  . ILE   B 1 109 ? -34.72387 -10.44479 78.59294 1.000 35.71184 ? 109 ILE   B CA  1 
ATOM   2767 C  C   . ILE   B 1 109 ? -34.60762 -11.58416 77.58872 1.000 33.28283 ? 109 ILE   B C   1 
ATOM   2768 O  O   . ILE   B 1 109 ? -35.61482 -12.16559 77.16728 1.000 36.85415 ? 109 ILE   B O   1 
ATOM   2769 C  CB  . ILE   B 1 109 ? -34.77381 -9.06684  77.90695 1.000 37.17408 ? 109 ILE   B CB  1 
ATOM   2770 C  CG1 . ILE   B 1 109 ? -35.36465 -8.03746  78.87311 1.000 35.92868 ? 109 ILE   B CG1 1 
ATOM   2771 C  CG2 . ILE   B 1 109 ? -35.55843 -9.12001  76.60258 1.000 30.63063 ? 109 ILE   B CG2 1 
ATOM   2772 C  CD1 . ILE   B 1 109 ? -35.02458 -6.61683  78.53419 1.000 41.65705 ? 109 ILE   B CD1 1 
ATOM   2773 N  N   . ALA   B 1 110 ? -33.37815 -11.93985 77.20923 1.000 37.83147 ? 110 ALA   B N   1 
ATOM   2774 C  CA  . ALA   B 1 110 ? -33.17810 -13.10223 76.35033 1.000 34.36137 ? 110 ALA   B CA  1 
ATOM   2775 C  C   . ALA   B 1 110 ? -33.60059 -14.38235 77.06134 1.000 41.49273 ? 110 ALA   B C   1 
ATOM   2776 O  O   . ALA   B 1 110 ? -34.31383 -15.21729 76.49265 1.000 39.99905 ? 110 ALA   B O   1 
ATOM   2777 C  CB  . ALA   B 1 110 ? -31.71644 -13.18135 75.90960 1.000 30.08234 ? 110 ALA   B CB  1 
ATOM   2778 N  N   . GLU   B 1 111 ? -33.17141 -14.54913 78.31470 1.000 37.71318 ? 111 GLU   B N   1 
ATOM   2779 C  CA  . GLU   B 1 111 ? -33.56936 -15.71902 79.09156 1.000 41.79127 ? 111 GLU   B CA  1 
ATOM   2780 C  C   . GLU   B 1 111 ? -35.08131 -15.76308 79.28194 1.000 39.14369 ? 111 GLU   B C   1 
ATOM   2781 O  O   . GLU   B 1 111 ? -35.71854 -16.79961 79.06160 1.000 41.26931 ? 111 GLU   B O   1 
ATOM   2782 C  CB  . GLU   B 1 111 ? -32.85792 -15.71076 80.44640 1.000 43.67658 ? 111 GLU   B CB  1 
ATOM   2783 C  CG  . GLU   B 1 111 ? -31.35961 -15.96762 80.37646 1.000 48.30183 ? 111 GLU   B CG  1 
ATOM   2784 C  CD  . GLU   B 1 111 ? -30.63729 -15.56903 81.65187 1.000 51.88314 ? 111 GLU   B CD  1 
ATOM   2785 O  OE1 . GLU   B 1 111 ? -29.48853 -16.01747 81.85195 1.000 50.77725 ? 111 GLU   B OE1 1 
ATOM   2786 O  OE2 . GLU   B 1 111 ? -31.21479 -14.80165 82.45094 1.000 45.97962 ? 111 GLU   B OE2 1 
ATOM   2787 N  N   . LEU   B 1 112 ? -35.67518 -14.63406 79.67592 1.000 37.32924 ? 112 LEU   B N   1 
ATOM   2788 C  CA  . LEU   B 1 112 ? -37.09150 -14.61709 80.02755 1.000 41.01871 ? 112 LEU   B CA  1 
ATOM   2789 C  C   . LEU   B 1 112 ? -37.99240 -14.78574 78.80953 1.000 44.12000 ? 112 LEU   B C   1 
ATOM   2790 O  O   . LEU   B 1 112 ? -39.09001 -15.34173 78.92943 1.000 43.59456 ? 112 LEU   B O   1 
ATOM   2791 C  CB  . LEU   B 1 112 ? -37.42822 -13.31838 80.76007 1.000 40.44399 ? 112 LEU   B CB  1 
ATOM   2792 C  CG  . LEU   B 1 112 ? -36.72385 -13.11155 82.10247 1.000 39.99257 ? 112 LEU   B CG  1 
ATOM   2793 C  CD1 . LEU   B 1 112 ? -36.86366 -11.67312 82.57028 1.000 44.61389 ? 112 LEU   B CD1 1 
ATOM   2794 C  CD2 . LEU   B 1 112 ? -37.27635 -14.07019 83.14487 1.000 40.32372 ? 112 LEU   B CD2 1 
ATOM   2795 N  N   . SER   B 1 113 ? -37.56007 -14.32054 77.64011 1.000 41.83245 ? 113 SER   B N   1 
ATOM   2796 C  CA  . SER   B 1 113 ? -38.38714 -14.37627 76.44130 1.000 43.37073 ? 113 SER   B CA  1 
ATOM   2797 C  C   . SER   B 1 113 ? -38.26282 -15.69204 75.68462 1.000 42.31655 ? 113 SER   B C   1 
ATOM   2798 O  O   . SER   B 1 113 ? -38.87364 -15.83493 74.62029 1.000 43.60369 ? 113 SER   B O   1 
ATOM   2799 C  CB  . SER   B 1 113 ? -38.03544 -13.21894 75.50085 1.000 42.14719 ? 113 SER   B CB  1 
ATOM   2800 O  OG  . SER   B 1 113 ? -36.73972 -13.38928 74.95354 1.000 41.00907 ? 113 SER   B OG  1 
ATOM   2801 N  N   . GLY   B 1 114 ? -37.50324 -16.65163 76.20091 1.000 40.20442 ? 114 GLY   B N   1 
ATOM   2802 C  CA  . GLY   B 1 114 ? -37.26811 -17.88124 75.46890 1.000 38.63348 ? 114 GLY   B CA  1 
ATOM   2803 C  C   . GLY   B 1 114 ? -36.30007 -17.71976 74.31957 1.000 38.46991 ? 114 GLY   B C   1 
ATOM   2804 O  O   . GLY   B 1 114 ? -36.52832 -18.27661 73.23732 1.000 38.08910 ? 114 GLY   B O   1 
ATOM   2805 N  N   . ASN   B 1 115 ? -35.21731 -16.96841 74.53028 1.000 43.76781 ? 115 ASN   B N   1 
ATOM   2806 C  CA  . ASN   B 1 115 ? -34.24499 -16.64084 73.48665 1.000 39.50201 ? 115 ASN   B CA  1 
ATOM   2807 C  C   . ASN   B 1 115 ? -34.91498 -15.90334 72.32854 1.000 36.39787 ? 115 ASN   B C   1 
ATOM   2808 O  O   . ASN   B 1 115 ? -34.69676 -16.20567 71.15324 1.000 34.40307 ? 115 ASN   B O   1 
ATOM   2809 C  CB  . ASN   B 1 115 ? -33.50769 -17.88925 72.99400 1.000 36.57288 ? 115 ASN   B CB  1 
ATOM   2810 C  CG  . ASN   B 1 115 ? -32.23542 -17.55222 72.23762 1.000 40.96077 ? 115 ASN   B CG  1 
ATOM   2811 O  OD1 . ASN   B 1 115 ? -31.64629 -16.48808 72.43341 1.000 34.27208 ? 115 ASN   B OD1 1 
ATOM   2812 N  ND2 . ASN   B 1 115 ? -31.80837 -18.45646 71.36512 1.000 40.41095 ? 115 ASN   B ND2 1 
ATOM   2813 N  N   . ARG   B 1 116 ? -35.74831 -14.91769 72.67511 1.000 37.09276 ? 116 ARG   B N   1 
ATOM   2814 C  CA  . ARG   B 1 116 ? -36.33946 -14.01463 71.68483 1.000 34.63009 ? 116 ARG   B CA  1 
ATOM   2815 C  C   . ARG   B 1 116 ? -36.17989 -12.54792 72.09134 1.000 33.86879 ? 116 ARG   B C   1 
ATOM   2816 O  O   . ARG   B 1 116 ? -37.14490 -11.78326 72.07325 1.000 32.60228 ? 116 ARG   B O   1 
ATOM   2817 C  CB  . ARG   B 1 116 ? -37.81308 -14.35361 71.47754 1.000 34.33018 ? 116 ARG   B CB  1 
ATOM   2818 C  CG  . ARG   B 1 116 ? -38.07165 -15.74860 70.93195 1.000 38.47691 ? 116 ARG   B CG  1 
ATOM   2819 C  CD  . ARG   B 1 116 ? -37.57940 -15.88340 69.50146 1.000 35.17687 ? 116 ARG   B CD  1 
ATOM   2820 N  NE  . ARG   B 1 116 ? -38.11610 -17.07614 68.85309 1.000 38.72273 ? 116 ARG   B NE  1 
ATOM   2821 C  CZ  . ARG   B 1 116 ? -37.88032 -17.40890 67.58840 1.000 42.58710 ? 116 ARG   B CZ  1 
ATOM   2822 N  NH1 . ARG   B 1 116 ? -37.11437 -16.63724 66.82962 1.000 36.67951 ? 116 ARG   B NH1 1 
ATOM   2823 N  NH2 . ARG   B 1 116 ? -38.41062 -18.51354 67.08156 1.000 37.15463 ? 116 ARG   B NH2 1 
ATOM   2824 N  N   . PRO   B 1 117 ? -34.96466 -12.10958 72.45326 1.000 28.27506 ? 117 PRO   B N   1 
ATOM   2825 C  CA  . PRO   B 1 117 ? -34.81179 -10.69206 72.80896 1.000 28.34815 ? 117 PRO   B CA  1 
ATOM   2826 C  C   . PRO   B 1 117 ? -34.97265 -9.76681  71.61908 1.000 31.18319 ? 117 PRO   B C   1 
ATOM   2827 O  O   . PRO   B 1 117 ? -35.45239 -8.64067  71.78945 1.000 30.12878 ? 117 PRO   B O   1 
ATOM   2828 C  CB  . PRO   B 1 117 ? -33.39475 -10.62434 73.39241 1.000 30.64143 ? 117 PRO   B CB  1 
ATOM   2829 C  CG  . PRO   B 1 117 ? -32.66751 -11.69234 72.68614 1.000 28.92150 ? 117 PRO   B CG  1 
ATOM   2830 C  CD  . PRO   B 1 117 ? -33.66282 -12.80652 72.48801 1.000 27.14493 ? 117 PRO   B CD  1 
ATOM   2831 N  N   . LEU   B 1 118 ? -34.59437 -10.20737 70.41738 1.000 30.55093 ? 118 LEU   B N   1 
ATOM   2832 C  CA  . LEU   B 1 118 ? -34.74968 -9.36105  69.23916 1.000 28.36975 ? 118 LEU   B CA  1 
ATOM   2833 C  C   . LEU   B 1 118 ? -36.21962 -9.06778  68.96654 1.000 28.05472 ? 118 LEU   B C   1 
ATOM   2834 O  O   . LEU   B 1 118 ? -36.60002 -7.91633  68.72894 1.000 32.73128 ? 118 LEU   B O   1 
ATOM   2835 C  CB  . LEU   B 1 118 ? -34.09552 -10.02120 68.02524 1.000 23.54084 ? 118 LEU   B CB  1 
ATOM   2836 C  CG  . LEU   B 1 118 ? -34.14944 -9.20366  66.73373 1.000 27.21664 ? 118 LEU   B CG  1 
ATOM   2837 C  CD1 . LEU   B 1 118 ? -33.54963 -7.82493  66.95629 1.000 20.84753 ? 118 LEU   B CD1 1 
ATOM   2838 C  CD2 . LEU   B 1 118 ? -33.43407 -9.92729  65.60411 1.000 23.12827 ? 118 LEU   B CD2 1 
ATOM   2839 N  N   . THR   B 1 119 ? -37.06504 -10.10017 69.01012 1.000 26.81473 ? 119 THR   B N   1 
ATOM   2840 C  CA  . THR   B 1 119 ? -38.48539 -9.90930  68.72980 1.000 33.21000 ? 119 THR   B CA  1 
ATOM   2841 C  C   . THR   B 1 119 ? -39.13496 -8.98948  69.75836 1.000 34.49428 ? 119 THR   B C   1 
ATOM   2842 O  O   . THR   B 1 119 ? -39.77299 -7.99266  69.39997 1.000 34.37729 ? 119 THR   B O   1 
ATOM   2843 C  CB  . THR   B 1 119 ? -39.20343 -11.26027 68.69160 1.000 25.61600 ? 119 THR   B CB  1 
ATOM   2844 O  OG1 . THR   B 1 119 ? -38.65874 -12.06781 67.63935 1.000 25.11331 ? 119 THR   B OG1 1 
ATOM   2845 C  CG2 . THR   B 1 119 ? -40.69625 -11.06589 68.45409 1.000 33.28086 ? 119 THR   B CG2 1 
ATOM   2846 N  N   . VAL   B 1 120 ? -38.97216 -9.30084  71.04760 1.000 34.18599 ? 120 VAL   B N   1 
ATOM   2847 C  CA  . VAL   B 1 120 ? -39.70236 -8.56342  72.07542 1.000 31.42301 ? 120 VAL   B CA  1 
ATOM   2848 C  C   . VAL   B 1 120 ? -39.17747 -7.13787  72.21550 1.000 34.42709 ? 120 VAL   B C   1 
ATOM   2849 O  O   . VAL   B 1 120 ? -39.94657 -6.21768  72.51837 1.000 39.50815 ? 120 VAL   B O   1 
ATOM   2850 C  CB  . VAL   B 1 120 ? -39.66157 -9.32151  73.41824 1.000 32.34929 ? 120 VAL   B CB  1 
ATOM   2851 C  CG1 . VAL   B 1 120 ? -40.10376 -10.76647 73.22745 1.000 27.17947 ? 120 VAL   B CG1 1 
ATOM   2852 C  CG2 . VAL   B 1 120 ? -38.27603 -9.25914  74.04908 1.000 29.56777 ? 120 VAL   B CG2 1 
ATOM   2853 N  N   . ILE   B 1 121 ? -37.87931 -6.91871  71.99336 1.000 28.69841 ? 121 ILE   B N   1 
ATOM   2854 C  CA  . ILE   B 1 121 ? -37.34086 -5.56608  72.10110 1.000 32.12067 ? 121 ILE   B CA  1 
ATOM   2855 C  C   . ILE   B 1 121 ? -37.75248 -4.73482  70.89289 1.000 33.60828 ? 121 ILE   B C   1 
ATOM   2856 O  O   . ILE   B 1 121 ? -38.06775 -3.54525  71.01894 1.000 27.24168 ? 121 ILE   B O   1 
ATOM   2857 C  CB  . ILE   B 1 121 ? -35.81143 -5.60983  72.28167 1.000 28.25974 ? 121 ILE   B CB  1 
ATOM   2858 C  CG1 . ILE   B 1 121 ? -35.46205 -6.06725  73.70052 1.000 35.75620 ? 121 ILE   B CG1 1 
ATOM   2859 C  CG2 . ILE   B 1 121 ? -35.17966 -4.25571  71.98771 1.000 24.49911 ? 121 ILE   B CG2 1 
ATOM   2860 C  CD1 . ILE   B 1 121 ? -33.98310 -6.28762  73.92773 1.000 26.69613 ? 121 ILE   B CD1 1 
ATOM   2861 N  N   . MET   B 1 122 ? -37.77274 -5.34769  69.70682 1.000 31.26620 ? 122 MET   B N   1 
ATOM   2862 C  CA  . MET   B 1 122 ? -38.25549 -4.64685  68.52105 1.000 35.93734 ? 122 MET   B CA  1 
ATOM   2863 C  C   . MET   B 1 122 ? -39.74021 -4.33155  68.63910 1.000 41.73283 ? 122 MET   B C   1 
ATOM   2864 O  O   . MET   B 1 122 ? -40.16981 -3.21175  68.33746 1.000 42.52404 ? 122 MET   B O   1 
ATOM   2865 C  CB  . MET   B 1 122 ? -37.98121 -5.47509  67.26722 1.000 33.78240 ? 122 MET   B CB  1 
ATOM   2866 C  CG  . MET   B 1 122 ? -36.54945 -5.40706  66.78090 1.000 20.60392 ? 122 MET   B CG  1 
ATOM   2867 S  SD  . MET   B 1 122 ? -36.19880 -3.85052  65.94535 1.000 28.73740 ? 122 MET   B SD  1 
ATOM   2868 C  CE  . MET   B 1 122 ? -37.08228 -4.09074  64.40619 1.000 16.94007 ? 122 MET   B CE  1 
ATOM   2869 N  N   . HIS   B 1 123 ? -40.53902 -5.31175  69.07036 1.000 39.65102 ? 123 HIS   B N   1 
ATOM   2870 C  CA  . HIS   B 1 123 ? -41.96092 -5.10460  69.31768 1.000 42.27165 ? 123 HIS   B CA  1 
ATOM   2871 C  C   . HIS   B 1 123 ? -42.14553 -3.89827  70.22770 1.000 44.79175 ? 123 HIS   B C   1 
ATOM   2872 O  O   . HIS   B 1 123 ? -42.67145 -2.86683  69.79724 1.000 46.32218 ? 123 HIS   B O   1 
ATOM   2873 C  CB  . HIS   B 1 123 ? -42.59242 -6.35217  69.94549 1.000 43.65486 ? 123 HIS   B CB  1 
ATOM   2874 C  CG  . HIS   B 1 123 ? -44.08076 -6.43009  69.78435 1.000 57.44491 ? 123 HIS   B CG  1 
ATOM   2875 N  ND1 . HIS   B 1 123 ? -44.83923 -5.36844  69.34351 1.000 58.28076 ? 123 HIS   B ND1 1 
ATOM   2876 C  CD2 . HIS   B 1 123 ? -44.95008 -7.44783  69.99837 1.000 60.29973 ? 123 HIS   B CD2 1 
ATOM   2877 C  CE1 . HIS   B 1 123 ? -46.10963 -5.72910  69.29015 1.000 58.16841 ? 123 HIS   B CE1 1 
ATOM   2878 N  NE2 . HIS   B 1 123 ? -46.20512 -6.98495  69.68516 1.000 60.23196 ? 123 HIS   B NE2 1 
ATOM   2879 N  N   . THR   B 1 124 ? -41.68296 -4.01903  71.47576 1.000 40.78414 ? 124 THR   B N   1 
ATOM   2880 C  CA  . THR   B 1 124 ? -41.79557 -2.94220  72.45751 1.000 41.60459 ? 124 THR   B CA  1 
ATOM   2881 C  C   . THR   B 1 124 ? -41.40948 -1.58452  71.88050 1.000 46.01544 ? 124 THR   B C   1 
ATOM   2882 O  O   . THR   B 1 124 ? -42.12755 -0.59555  72.05609 1.000 44.54780 ? 124 THR   B O   1 
ATOM   2883 C  CB  . THR   B 1 124 ? -40.92120 -3.25948  73.67586 1.000 39.95879 ? 124 THR   B CB  1 
ATOM   2884 O  OG1 . THR   B 1 124 ? -41.42236 -4.42212  74.34652 1.000 40.76693 ? 124 THR   B OG1 1 
ATOM   2885 C  CG2 . THR   B 1 124 ? -40.91024 -2.08494  74.64367 1.000 38.36496 ? 124 THR   B CG2 1 
ATOM   2886 N  N   . ILE   B 1 125 ? -40.27966 -1.52565  71.17227 1.000 39.61898 ? 125 ILE   B N   1 
ATOM   2887 C  CA  . ILE   B 1 125 ? -39.78657 -0.25063  70.65872 1.000 43.27555 ? 125 ILE   B CA  1 
ATOM   2888 C  C   . ILE   B 1 125 ? -40.71557 0.29765   69.58086 1.000 42.10545 ? 125 ILE   B C   1 
ATOM   2889 O  O   . ILE   B 1 125 ? -40.94861 1.51050   69.50418 1.000 45.61657 ? 125 ILE   B O   1 
ATOM   2890 C  CB  . ILE   B 1 125 ? -38.34159 -0.41371  70.15177 1.000 36.92855 ? 125 ILE   B CB  1 
ATOM   2891 C  CG1 . ILE   B 1 125 ? -37.37624 -0.41319  71.33778 1.000 39.38639 ? 125 ILE   B CG1 1 
ATOM   2892 C  CG2 . ILE   B 1 125 ? -37.97759 0.67739   69.15698 1.000 30.24580 ? 125 ILE   B CG2 1 
ATOM   2893 C  CD1 . ILE   B 1 125 ? -35.96156 -0.77899  70.98117 1.000 37.27339 ? 125 ILE   B CD1 1 
ATOM   2894 N  N   . PHE   B 1 126 ? -41.27117 -0.57997  68.74073 1.000 41.36084 ? 126 PHE   B N   1 
ATOM   2895 C  CA  . PHE   B 1 126 ? -42.20180 -0.12160  67.71257 1.000 43.86848 ? 126 PHE   B CA  1 
ATOM   2896 C  C   . PHE   B 1 126 ? -43.44048 0.51604   68.33404 1.000 47.72394 ? 126 PHE   B C   1 
ATOM   2897 O  O   . PHE   B 1 126 ? -43.99694 1.47329   67.78414 1.000 42.98251 ? 126 PHE   B O   1 
ATOM   2898 C  CB  . PHE   B 1 126 ? -42.58979 -1.27970  66.79177 1.000 39.70505 ? 126 PHE   B CB  1 
ATOM   2899 C  CG  . PHE   B 1 126 ? -41.69750 -1.42464  65.58331 1.000 44.03226 ? 126 PHE   B CG  1 
ATOM   2900 C  CD1 . PHE   B 1 126 ? -40.31803 -1.37013  65.70755 1.000 40.08623 ? 126 PHE   B CD1 1 
ATOM   2901 C  CD2 . PHE   B 1 126 ? -42.24212 -1.62999  64.32458 1.000 42.50156 ? 126 PHE   B CD2 1 
ATOM   2902 C  CE1 . PHE   B 1 126 ? -39.49911 -1.50859  64.59672 1.000 41.57016 ? 126 PHE   B CE1 1 
ATOM   2903 C  CE2 . PHE   B 1 126 ? -41.42895 -1.77078  63.21208 1.000 39.59697 ? 126 PHE   B CE2 1 
ATOM   2904 C  CZ  . PHE   B 1 126 ? -40.05675 -1.71044  63.34855 1.000 41.42422 ? 126 PHE   B CZ  1 
ATOM   2905 N  N   . GLN   B 1 127 ? -43.88434 0.00753   69.48525 1.000 49.67186 ? 127 GLN   B N   1 
ATOM   2906 C  CA  . GLN   B 1 127 ? -44.98193 0.65494   70.19798 1.000 49.87339 ? 127 GLN   B CA  1 
ATOM   2907 C  C   . GLN   B 1 127 ? -44.54275 1.97586   70.80762 1.000 48.77956 ? 127 GLN   B C   1 
ATOM   2908 O  O   . GLN   B 1 127 ? -45.21239 3.00330   70.64254 1.000 53.36255 ? 127 GLN   B O   1 
ATOM   2909 C  CB  . GLN   B 1 127 ? -45.51486 -0.25311  71.29781 1.000 46.30742 ? 127 GLN   B CB  1 
ATOM   2910 C  CG  . GLN   B 1 127 ? -46.65429 -1.12628  70.87807 1.000 54.94043 ? 127 GLN   B CG  1 
ATOM   2911 C  CD  . GLN   B 1 127 ? -46.20791 -2.47355  70.43624 1.000 58.34696 ? 127 GLN   B CD  1 
ATOM   2912 O  OE1 . GLN   B 1 127 ? -45.25433 -2.62197  69.67804 1.000 60.88989 ? 127 GLN   B OE1 1 
ATOM   2913 N  NE2 . GLN   B 1 127 ? -46.87554 -3.48523  70.94256 1.000 62.16571 ? 127 GLN   B NE2 1 
ATOM   2914 N  N   . GLU   B 1 128 ? -43.43960 1.94816   71.56013 1.000 46.95981 ? 128 GLU   B N   1 
ATOM   2915 C  CA  . GLU   B 1 128 ? -42.96809 3.13254   72.26741 1.000 48.14522 ? 128 GLU   B CA  1 
ATOM   2916 C  C   . GLU   B 1 128 ? -42.83707 4.32174   71.32909 1.000 53.51712 ? 128 GLU   B C   1 
ATOM   2917 O  O   . GLU   B 1 128 ? -43.10304 5.46399   71.71847 1.000 49.71080 ? 128 GLU   B O   1 
ATOM   2918 C  CB  . GLU   B 1 128 ? -41.62965 2.82498   72.93943 1.000 44.37410 ? 128 GLU   B CB  1 
ATOM   2919 C  CG  . GLU   B 1 128 ? -41.07616 3.94594   73.80530 1.000 47.56927 ? 128 GLU   B CG  1 
ATOM   2920 C  CD  . GLU   B 1 128 ? -41.87977 4.16322   75.07397 1.000 51.20568 ? 128 GLU   B CD  1 
ATOM   2921 O  OE1 . GLU   B 1 128 ? -41.70957 5.22351   75.71214 1.000 53.51263 ? 128 GLU   B OE1 1 
ATOM   2922 O  OE2 . GLU   B 1 128 ? -42.67775 3.27367   75.43742 1.000 48.85319 ? 128 GLU   B OE2 1 
ATOM   2923 N  N   . ARG   B 1 129 ? -42.44190 4.07001   70.08407 1.000 52.42373 ? 129 ARG   B N   1 
ATOM   2924 C  CA  . ARG   B 1 129 ? -42.30947 5.11302   69.07996 1.000 47.84896 ? 129 ARG   B CA  1 
ATOM   2925 C  C   . ARG   B 1 129 ? -43.51169 5.19915   68.15057 1.000 47.42514 ? 129 ARG   B C   1 
ATOM   2926 O  O   . ARG   B 1 129 ? -43.53725 6.07464   67.27977 1.000 50.16378 ? 129 ARG   B O   1 
ATOM   2927 C  CB  . ARG   B 1 129 ? -41.03196 4.89739   68.26784 1.000 44.71031 ? 129 ARG   B CB  1 
ATOM   2928 C  CG  . ARG   B 1 129 ? -39.77454 5.12452   69.08137 1.000 43.38459 ? 129 ARG   B CG  1 
ATOM   2929 C  CD  . ARG   B 1 129 ? -38.52182 5.03456   68.23595 1.000 32.94735 ? 129 ARG   B CD  1 
ATOM   2930 N  NE  . ARG   B 1 129 ? -37.35092 5.44718   69.00094 1.000 32.84675 ? 129 ARG   B NE  1 
ATOM   2931 C  CZ  . ARG   B 1 129 ? -37.00139 6.71373   69.19960 1.000 43.19580 ? 129 ARG   B CZ  1 
ATOM   2932 N  NH1 . ARG   B 1 129 ? -37.72997 7.69451   68.68343 1.000 46.95487 ? 129 ARG   B NH1 1 
ATOM   2933 N  NH2 . ARG   B 1 129 ? -35.92323 7.00098   69.91503 1.000 39.84283 ? 129 ARG   B NH2 1 
ATOM   2934 N  N   . ASP   B 1 130 ? -44.49564 4.30633   68.30580 1.000 44.93773 ? 130 ASP   B N   1 
ATOM   2935 C  CA  . ASP   B 1 130 ? -45.78099 4.40155   67.60780 1.000 50.59125 ? 130 ASP   B CA  1 
ATOM   2936 C  C   . ASP   B 1 130 ? -45.61319 4.18392   66.10050 1.000 49.35684 ? 130 ASP   B C   1 
ATOM   2937 O  O   . ASP   B 1 130 ? -46.10139 4.96374   65.28186 1.000 45.89506 ? 130 ASP   B O   1 
ATOM   2938 C  CB  . ASP   B 1 130 ? -46.45939 5.74415   67.90538 1.000 52.07384 ? 130 ASP   B CB  1 
ATOM   2939 C  CG  . ASP   B 1 130 ? -47.95450 5.71046   67.67900 1.000 55.44297 ? 130 ASP   B CG  1 
ATOM   2940 O  OD1 . ASP   B 1 130 ? -48.53151 4.60479   67.67574 1.000 54.23462 ? 130 ASP   B OD1 1 
ATOM   2941 O  OD2 . ASP   B 1 130 ? -48.55387 6.79333   67.51630 1.000 60.41877 ? 130 ASP   B OD2 1 
ATOM   2942 N  N   . LEU   B 1 131 ? -44.92483 3.09744   65.73967 1.000 48.22714 ? 131 LEU   B N   1 
ATOM   2943 C  CA  . LEU   B 1 131 ? -44.61101 2.80295   64.34642 1.000 40.68876 ? 131 LEU   B CA  1 
ATOM   2944 C  C   . LEU   B 1 131 ? -45.58202 1.83323   63.68731 1.000 43.89953 ? 131 LEU   B C   1 
ATOM   2945 O  O   . LEU   B 1 131 ? -45.71352 1.86009   62.45754 1.000 42.54754 ? 131 LEU   B O   1 
ATOM   2946 C  CB  . LEU   B 1 131 ? -43.19027 2.23741   64.23075 1.000 36.28050 ? 131 LEU   B CB  1 
ATOM   2947 C  CG  . LEU   B 1 131 ? -42.07414 3.09829   64.82222 1.000 41.10653 ? 131 LEU   B CG  1 
ATOM   2948 C  CD1 . LEU   B 1 131 ? -40.75982 2.33737   64.80605 1.000 41.87139 ? 131 LEU   B CD1 1 
ATOM   2949 C  CD2 . LEU   B 1 131 ? -41.95023 4.41066   64.06381 1.000 38.41609 ? 131 LEU   B CD2 1 
ATOM   2950 N  N   . LEU   B 1 132 ? -46.25671 0.97628   64.46137 1.000 42.37267 ? 132 LEU   B N   1 
ATOM   2951 C  CA  . LEU   B 1 132 ? -47.25244 0.08021   63.87681 1.000 45.18325 ? 132 LEU   B CA  1 
ATOM   2952 C  C   . LEU   B 1 132 ? -48.42299 0.83594   63.26385 1.000 50.48204 ? 132 LEU   B C   1 
ATOM   2953 O  O   . LEU   B 1 132 ? -49.16501 0.25611   62.46328 1.000 49.52563 ? 132 LEU   B O   1 
ATOM   2954 C  CB  . LEU   B 1 132 ? -47.77007 -0.91220  64.92079 1.000 47.62850 ? 132 LEU   B CB  1 
ATOM   2955 C  CG  . LEU   B 1 132 ? -46.80769 -2.01963  65.35479 1.000 47.87590 ? 132 LEU   B CG  1 
ATOM   2956 C  CD1 . LEU   B 1 132 ? -46.48374 -1.88948  66.82657 1.000 48.63165 ? 132 LEU   B CD1 1 
ATOM   2957 C  CD2 . LEU   B 1 132 ? -47.39289 -3.38826  65.04739 1.000 41.31796 ? 132 LEU   B CD2 1 
ATOM   2958 N  N   . LYS   B 1 133 ? -48.60579 2.10658   63.61579 1.000 44.26038 ? 133 LYS   B N   1 
ATOM   2959 C  CA  . LYS   B 1 133 ? -49.64525 2.94352   63.03626 1.000 50.40521 ? 133 LYS   B CA  1 
ATOM   2960 C  C   . LYS   B 1 133 ? -49.10872 4.06972   62.17119 1.000 46.78954 ? 133 LYS   B C   1 
ATOM   2961 O  O   . LYS   B 1 133 ? -49.71513 4.38857   61.15078 1.000 45.90586 ? 133 LYS   B O   1 
ATOM   2962 C  CB  . LYS   B 1 133 ? -50.53507 3.53478   64.13314 1.000 59.59609 ? 133 LYS   B CB  1 
ATOM   2963 C  CG  . LYS   B 1 133 ? -51.45410 2.49997   64.77507 1.000 60.81820 ? 133 LYS   B CG  1 
ATOM   2964 C  CD  . LYS   B 1 133 ? -51.44216 2.64170   66.29474 1.000 65.50575 ? 133 LYS   B CD  1 
ATOM   2965 C  CE  . LYS   B 1 133 ? -52.51014 1.77040   66.93101 1.000 70.58716 ? 133 LYS   B CE  1 
ATOM   2966 N  NZ  . LYS   B 1 133 ? -51.99977 1.01056   68.09384 1.000 69.93285 ? 133 LYS   B NZ  1 
ATOM   2967 N  N   . THR   B 1 134 ? -47.99761 4.69421   62.56488 1.000 44.16678 ? 134 THR   B N   1 
ATOM   2968 C  CA  . THR   B 1 134 ? -47.38481 5.70755   61.71097 1.000 43.65295 ? 134 THR   B CA  1 
ATOM   2969 C  C   . THR   B 1 134 ? -47.10339 5.15169   60.32240 1.000 43.57499 ? 134 THR   B C   1 
ATOM   2970 O  O   . THR   B 1 134 ? -47.17479 5.88190   59.32658 1.000 40.93806 ? 134 THR   B O   1 
ATOM   2971 C  CB  . THR   B 1 134 ? -46.08713 6.23869   62.34124 1.000 45.06611 ? 134 THR   B CB  1 
ATOM   2972 O  OG1 . THR   B 1 134 ? -46.38096 6.87914   63.59090 1.000 43.64047 ? 134 THR   B OG1 1 
ATOM   2973 C  CG2 . THR   B 1 134 ? -45.39316 7.23663   61.42303 1.000 43.21288 ? 134 THR   B CG2 1 
ATOM   2974 N  N   . PHE   B 1 135 ? -46.80927 3.85589   60.23224 1.000 44.62738 ? 135 PHE   B N   1 
ATOM   2975 C  CA  . PHE   B 1 135 ? -46.56525 3.20058   58.95471 1.000 40.87929 ? 135 PHE   B CA  1 
ATOM   2976 C  C   . PHE   B 1 135 ? -47.52040 2.04313   58.68904 1.000 40.59076 ? 135 PHE   B C   1 
ATOM   2977 O  O   . PHE   B 1 135 ? -47.26981 1.25385   57.77047 1.000 36.13129 ? 135 PHE   B O   1 
ATOM   2978 C  CB  . PHE   B 1 135 ? -45.11248 2.72557   58.88158 1.000 31.42952 ? 135 PHE   B CB  1 
ATOM   2979 C  CG  . PHE   B 1 135 ? -44.11672 3.84124   58.98754 1.000 36.47321 ? 135 PHE   B CG  1 
ATOM   2980 C  CD1 . PHE   B 1 135 ? -43.93510 4.72210   57.93457 1.000 36.48868 ? 135 PHE   B CD1 1 
ATOM   2981 C  CD2 . PHE   B 1 135 ? -43.37246 4.01931   60.14163 1.000 34.14693 ? 135 PHE   B CD2 1 
ATOM   2982 C  CE1 . PHE   B 1 135 ? -43.02523 5.75568   58.02642 1.000 41.07888 ? 135 PHE   B CE1 1 
ATOM   2983 C  CE2 . PHE   B 1 135 ? -42.45880 5.05137   60.24035 1.000 37.52524 ? 135 PHE   B CE2 1 
ATOM   2984 C  CZ  . PHE   B 1 135 ? -42.28501 5.92120   59.18088 1.000 41.13738 ? 135 PHE   B CZ  1 
ATOM   2985 N  N   . LYS   B 1 136 ? -48.60293 1.92443   59.46149 1.000 39.77690 ? 136 LYS   B N   1 
ATOM   2986 C  CA  . LYS   B 1 136 ? -49.67391 0.95740   59.20355 1.000 42.79199 ? 136 LYS   B CA  1 
ATOM   2987 C  C   . LYS   B 1 136 ? -49.12971 -0.46454  59.06505 1.000 43.89782 ? 136 LYS   B C   1 
ATOM   2988 O  O   . LYS   B 1 136 ? -49.46803 -1.20598  58.13891 1.000 45.20588 ? 136 LYS   B O   1 
ATOM   2989 C  CB  . LYS   B 1 136 ? -50.48289 1.36635   57.97114 1.000 43.55063 ? 136 LYS   B CB  1 
ATOM   2990 C  CG  . LYS   B 1 136 ? -51.04851 2.77626   58.07280 1.000 42.29961 ? 136 LYS   B CG  1 
ATOM   2991 C  CD  . LYS   B 1 136 ? -51.75782 3.20710   56.80027 1.000 47.34549 ? 136 LYS   B CD  1 
ATOM   2992 C  CE  . LYS   B 1 136 ? -52.13001 4.68274   56.85886 1.000 53.12641 ? 136 LYS   B CE  1 
ATOM   2993 N  NZ  . LYS   B 1 136 ? -52.47699 5.22956   55.51751 1.000 51.25793 ? 136 LYS   B NZ  1 
ATOM   2994 N  N   . ILE   B 1 137 ? -48.27505 -0.84129  60.00887 1.000 43.28718 ? 137 ILE   B N   1 
ATOM   2995 C  CA  . ILE   B 1 137 ? -47.69203 -2.17791  60.05530 1.000 46.43587 ? 137 ILE   B CA  1 
ATOM   2996 C  C   . ILE   B 1 137 ? -48.63711 -3.07223  60.85294 1.000 43.34531 ? 137 ILE   B C   1 
ATOM   2997 O  O   . ILE   B 1 137 ? -48.86761 -2.79920  62.04139 1.000 46.59040 ? 137 ILE   B O   1 
ATOM   2998 C  CB  . ILE   B 1 137 ? -46.29724 -2.15747  60.69088 1.000 43.79758 ? 137 ILE   B CB  1 
ATOM   2999 C  CG1 . ILE   B 1 137 ? -45.41820 -1.09771  60.02341 1.000 42.88641 ? 137 ILE   B CG1 1 
ATOM   3000 C  CG2 . ILE   B 1 137 ? -45.65078 -3.53085  60.60181 1.000 38.56168 ? 137 ILE   B CG2 1 
ATOM   3001 C  CD1 . ILE   B 1 137 ? -44.19820 -0.71978  60.83784 1.000 38.54657 ? 137 ILE   B CD1 1 
ATOM   3002 N  N   . PRO   B 1 138 ? -49.20282 -4.12008  60.25617 1.000 37.44455 ? 138 PRO   B N   1 
ATOM   3003 C  CA  . PRO   B 1 138 ? -50.06046 -5.02469  61.03096 1.000 36.47869 ? 138 PRO   B CA  1 
ATOM   3004 C  C   . PRO   B 1 138 ? -49.23333 -5.85202  62.00345 1.000 44.96083 ? 138 PRO   B C   1 
ATOM   3005 O  O   . PRO   B 1 138 ? -48.14033 -6.32013  61.67518 1.000 45.26732 ? 138 PRO   B O   1 
ATOM   3006 C  CB  . PRO   B 1 138 ? -50.72439 -5.89513  59.95825 1.000 38.04725 ? 138 PRO   B CB  1 
ATOM   3007 C  CG  . PRO   B 1 138 ? -49.79074 -5.84618  58.80117 1.000 39.13114 ? 138 PRO   B CG  1 
ATOM   3008 C  CD  . PRO   B 1 138 ? -49.12354 -4.50107  58.83571 1.000 41.83887 ? 138 PRO   B CD  1 
ATOM   3009 N  N   . VAL   B 1 139 ? -49.77580 -6.03322  63.21136 1.000 40.92096 ? 139 VAL   B N   1 
ATOM   3010 C  CA  . VAL   B 1 139 ? -48.96983 -6.52033  64.32983 1.000 42.00474 ? 139 VAL   B CA  1 
ATOM   3011 C  C   . VAL   B 1 139 ? -48.47474 -7.94026  64.07401 1.000 41.05210 ? 139 VAL   B C   1 
ATOM   3012 O  O   . VAL   B 1 139 ? -47.33287 -8.28006  64.40589 1.000 44.50394 ? 139 VAL   B O   1 
ATOM   3013 C  CB  . VAL   B 1 139 ? -49.76156 -6.40912  65.64982 1.000 44.98894 ? 139 VAL   B CB  1 
ATOM   3014 C  CG1 . VAL   B 1 139 ? -50.93455 -7.38567  65.68687 1.000 42.05057 ? 139 VAL   B CG1 1 
ATOM   3015 C  CG2 . VAL   B 1 139 ? -48.84051 -6.61130  66.84701 1.000 45.04062 ? 139 VAL   B CG2 1 
ATOM   3016 N  N   . ASP   B 1 140 ? -49.30894 -8.78503  63.46277 1.000 38.18312 ? 140 ASP   B N   1 
ATOM   3017 C  CA  . ASP   B 1 140 ? -48.90335 -10.16442 63.21435 1.000 42.03077 ? 140 ASP   B CA  1 
ATOM   3018 C  C   . ASP   B 1 140 ? -47.82929 -10.24758 62.13902 1.000 42.77741 ? 140 ASP   B C   1 
ATOM   3019 O  O   . ASP   B 1 140 ? -47.00976 -11.17350 62.15134 1.000 35.64820 ? 140 ASP   B O   1 
ATOM   3020 C  CB  . ASP   B 1 140 ? -50.11537 -11.00159 62.81534 1.000 41.12462 ? 140 ASP   B CB  1 
ATOM   3021 C  CG  . ASP   B 1 140 ? -50.82075 -10.44926 61.59634 1.000 47.54277 ? 140 ASP   B CG  1 
ATOM   3022 O  OD1 . ASP   B 1 140 ? -51.08477 -9.22846  61.56707 1.000 43.15261 ? 140 ASP   B OD1 1 
ATOM   3023 O  OD2 . ASP   B 1 140 ? -51.09968 -11.23101 60.66342 1.000 49.12007 ? 140 ASP   B OD2 1 
ATOM   3024 N  N   . THR   B 1 141 ? -47.82458 -9.30038  61.19974 1.000 42.80476 ? 141 THR   B N   1 
ATOM   3025 C  CA  . THR   B 1 141 ? -46.77075 -9.26070  60.19281 1.000 42.26469 ? 141 THR   B CA  1 
ATOM   3026 C  C   . THR   B 1 141 ? -45.43540 -8.87908  60.81697 1.000 38.97926 ? 141 THR   B C   1 
ATOM   3027 O  O   . THR   B 1 141 ? -44.38712 -9.41111  60.43195 1.000 36.13796 ? 141 THR   B O   1 
ATOM   3028 C  CB  . THR   B 1 141 ? -47.15070 -8.28175  59.08219 1.000 43.54702 ? 141 THR   B CB  1 
ATOM   3029 O  OG1 . THR   B 1 141 ? -48.38280 -8.69948  58.48111 1.000 48.41280 ? 141 THR   B OG1 1 
ATOM   3030 C  CG2 . THR   B 1 141 ? -46.06758 -8.22171  58.01594 1.000 41.68471 ? 141 THR   B CG2 1 
ATOM   3031 N  N   . LEU   B 1 142 ? -45.45633 -7.96335  61.78813 1.000 36.03652 ? 142 LEU   B N   1 
ATOM   3032 C  CA  . LEU   B 1 142 ? -44.23171 -7.60806  62.49497 1.000 36.63250 ? 142 LEU   B CA  1 
ATOM   3033 C  C   . LEU   B 1 142 ? -43.65569 -8.81090  63.23032 1.000 39.29616 ? 142 LEU   B C   1 
ATOM   3034 O  O   . LEU   B 1 142 ? -42.44035 -9.03349  63.21400 1.000 34.18488 ? 142 LEU   B O   1 
ATOM   3035 C  CB  . LEU   B 1 142 ? -44.50380 -6.46083  63.46834 1.000 39.17909 ? 142 LEU   B CB  1 
ATOM   3036 C  CG  . LEU   B 1 142 ? -43.29193 -5.85875  64.18171 1.000 37.37486 ? 142 LEU   B CG  1 
ATOM   3037 C  CD1 . LEU   B 1 142 ? -42.29323 -5.31523  63.17158 1.000 38.37350 ? 142 LEU   B CD1 1 
ATOM   3038 C  CD2 . LEU   B 1 142 ? -43.72452 -4.77300  65.15658 1.000 38.41287 ? 142 LEU   B CD2 1 
ATOM   3039 N  N   . ILE   B 1 143 ? -44.51607 -9.61238  63.86178 1.000 35.51059 ? 143 ILE   B N   1 
ATOM   3040 C  CA  . ILE   B 1 143 ? -44.03287 -10.74500 64.64505 1.000 32.38666 ? 143 ILE   B CA  1 
ATOM   3041 C  C   . ILE   B 1 143 ? -43.47209 -11.82948 63.73537 1.000 36.80902 ? 143 ILE   B C   1 
ATOM   3042 O  O   . ILE   B 1 143 ? -42.40110 -12.38709 64.00317 1.000 33.31248 ? 143 ILE   B O   1 
ATOM   3043 C  CB  . ILE   B 1 143 ? -45.15303 -11.29093 65.54785 1.000 38.69215 ? 143 ILE   B CB  1 
ATOM   3044 C  CG1 . ILE   B 1 143 ? -45.76831 -10.16317 66.37653 1.000 33.96883 ? 143 ILE   B CG1 1 
ATOM   3045 C  CG2 . ILE   B 1 143 ? -44.61349 -12.38485 66.45452 1.000 29.26365 ? 143 ILE   B CG2 1 
ATOM   3046 C  CD1 . ILE   B 1 143 ? -44.75324 -9.33055  67.12689 1.000 39.86620 ? 143 ILE   B CD1 1 
ATOM   3047 N  N   . THR   B 1 144 ? -44.18402 -12.14874 62.65075 1.000 34.14183 ? 144 THR   B N   1 
ATOM   3048 C  CA  . THR   B 1 144 ? -43.71826 -13.18948 61.73898 1.000 31.39850 ? 144 THR   B CA  1 
ATOM   3049 C  C   . THR   B 1 144 ? -42.34720 -12.85000 61.16883 1.000 32.30268 ? 144 THR   B C   1 
ATOM   3050 O  O   . THR   B 1 144 ? -41.47459 -13.72120 61.06977 1.000 29.20605 ? 144 THR   B O   1 
ATOM   3051 C  CB  . THR   B 1 144 ? -44.72804 -13.39571 60.60907 1.000 33.42612 ? 144 THR   B CB  1 
ATOM   3052 O  OG1 . THR   B 1 144 ? -46.05388 -13.43374 61.15129 1.000 37.00254 ? 144 THR   B OG1 1 
ATOM   3053 C  CG2 . THR   B 1 144 ? -44.44997 -14.70298 59.87865 1.000 29.89882 ? 144 THR   B CG2 1 
ATOM   3054 N  N   . TYR   B 1 145 ? -42.13289 -11.58657 60.79634 1.000 29.91360 ? 145 TYR   B N   1 
ATOM   3055 C  CA  . TYR   B 1 145 ? -40.82537 -11.19364 60.28421 1.000 26.76348 ? 145 TYR   B CA  1 
ATOM   3056 C  C   . TYR   B 1 145 ? -39.76998 -11.23338 61.38129 1.000 29.69090 ? 145 TYR   B C   1 
ATOM   3057 O  O   . TYR   B 1 145 ? -38.68718 -11.79953 61.19180 1.000 30.03359 ? 145 TYR   B O   1 
ATOM   3058 C  CB  . TYR   B 1 145 ? -40.87967 -9.80074  59.66167 1.000 27.51447 ? 145 TYR   B CB  1 
ATOM   3059 C  CG  . TYR   B 1 145 ? -39.50770 -9.33662  59.23991 1.000 23.94214 ? 145 TYR   B CG  1 
ATOM   3060 C  CD1 . TYR   B 1 145 ? -38.89818 -9.86688  58.11200 1.000 22.15612 ? 145 TYR   B CD1 1 
ATOM   3061 C  CD2 . TYR   B 1 145 ? -38.80501 -8.39971  59.98734 1.000 25.22499 ? 145 TYR   B CD2 1 
ATOM   3062 C  CE1 . TYR   B 1 145 ? -37.63799 -9.46450  57.72652 1.000 23.18312 ? 145 TYR   B CE1 1 
ATOM   3063 C  CE2 . TYR   B 1 145 ? -37.54123 -7.99026  59.60957 1.000 23.10503 ? 145 TYR   B CE2 1 
ATOM   3064 C  CZ  . TYR   B 1 145 ? -36.96365 -8.52648  58.47736 1.000 21.99006 ? 145 TYR   B CZ  1 
ATOM   3065 O  OH  . TYR   B 1 145 ? -35.70651 -8.12598  58.09109 1.000 23.89382 ? 145 TYR   B OH  1 
ATOM   3066 N  N   . LEU   B 1 146 ? -40.06240 -10.62087 62.53312 1.000 24.59140 ? 146 LEU   B N   1 
ATOM   3067 C  CA  . LEU   B 1 146 ? -39.09324 -10.59511 63.62434 1.000 31.22178 ? 146 LEU   B CA  1 
ATOM   3068 C  C   . LEU   B 1 146 ? -38.70512 -11.99979 64.06534 1.000 31.84614 ? 146 LEU   B C   1 
ATOM   3069 O  O   . LEU   B 1 146 ? -37.55500 -12.23090 64.45428 1.000 34.24934 ? 146 LEU   B O   1 
ATOM   3070 C  CB  . LEU   B 1 146 ? -39.65026 -9.80269  64.80770 1.000 27.49568 ? 146 LEU   B CB  1 
ATOM   3071 C  CG  . LEU   B 1 146 ? -39.79812 -8.29183  64.61454 1.000 28.18416 ? 146 LEU   B CG  1 
ATOM   3072 C  CD1 . LEU   B 1 146 ? -40.49249 -7.65927  65.81304 1.000 32.90653 ? 146 LEU   B CD1 1 
ATOM   3073 C  CD2 . LEU   B 1 146 ? -38.44839 -7.64375  64.36169 1.000 30.47039 ? 146 LEU   B CD2 1 
ATOM   3074 N  N   . MET   B 1 147 ? -39.64075 -12.94943 64.00429 1.000 32.03897 ? 147 MET   B N   1 
ATOM   3075 C  CA  . MET   B 1 147 ? -39.32330 -14.32542 64.37229 1.000 33.12519 ? 147 MET   B CA  1 
ATOM   3076 C  C   . MET   B 1 147 ? -38.42518 -14.97952 63.32882 1.000 32.77835 ? 147 MET   B C   1 
ATOM   3077 O  O   . MET   B 1 147 ? -37.42590 -15.62209 63.67173 1.000 35.91633 ? 147 MET   B O   1 
ATOM   3078 C  CB  . MET   B 1 147 ? -40.61155 -15.12670 64.56261 1.000 38.74746 ? 147 MET   B CB  1 
ATOM   3079 C  CG  . MET   B 1 147 ? -41.38931 -14.75146 65.81489 1.000 43.11444 ? 147 MET   B CG  1 
ATOM   3080 S  SD  . MET   B 1 147 ? -40.69306 -15.44254 67.32566 1.000 61.00986 ? 147 MET   B SD  1 
ATOM   3081 C  CE  . MET   B 1 147 ? -41.36656 -17.09975 67.26374 1.000 62.97457 ? 147 MET   B CE  1 
ATOM   3082 N  N   . THR   B 1 148 ? -38.76485 -14.82695 62.04590 1.000 31.15764 ? 148 THR   B N   1 
ATOM   3083 C  CA  . THR   B 1 148 ? -37.91875 -15.37813 60.99165 1.000 31.56425 ? 148 THR   B CA  1 
ATOM   3084 C  C   . THR   B 1 148 ? -36.54884 -14.71341 60.98720 1.000 27.52109 ? 148 THR   B C   1 
ATOM   3085 O  O   . THR   B 1 148 ? -35.52659 -15.37872 60.78127 1.000 23.57500 ? 148 THR   B O   1 
ATOM   3086 C  CB  . THR   B 1 148 ? -38.59144 -15.21160 59.62923 1.000 31.18462 ? 148 THR   B CB  1 
ATOM   3087 O  OG1 . THR   B 1 148 ? -40.00517 -15.39983 59.76455 1.000 37.59888 ? 148 THR   B OG1 1 
ATOM   3088 C  CG2 . THR   B 1 148 ? -38.04194 -16.22999 58.63961 1.000 25.72934 ? 148 THR   B CG2 1 
ATOM   3089 N  N   . LEU   B 1 149 ? -36.51091 -13.39832 61.21286 1.000 26.03695 ? 149 LEU   B N   1 
ATOM   3090 C  CA  . LEU   B 1 149 ? -35.23888 -12.68611 61.26638 1.000 27.06359 ? 149 LEU   B CA  1 
ATOM   3091 C  C   . LEU   B 1 149 ? -34.38236 -13.18407 62.42216 1.000 29.26878 ? 149 LEU   B C   1 
ATOM   3092 O  O   . LEU   B 1 149 ? -33.18494 -13.44511 62.25726 1.000 24.33627 ? 149 LEU   B O   1 
ATOM   3093 C  CB  . LEU   B 1 149 ? -35.48613 -11.18367 61.39392 1.000 23.98840 ? 149 LEU   B CB  1 
ATOM   3094 C  CG  . LEU   B 1 149 ? -34.22572 -10.32679 61.51440 1.000 27.29850 ? 149 LEU   B CG  1 
ATOM   3095 C  CD1 . LEU   B 1 149 ? -33.46175 -10.32081 60.20017 1.000 24.98870 ? 149 LEU   B CD1 1 
ATOM   3096 C  CD2 . LEU   B 1 149 ? -34.56397 -8.91177  61.95718 1.000 23.37691 ? 149 LEU   B CD2 1 
ATOM   3097 N  N   . GLU   B 1 150 ? -34.98450 -13.31810 63.60601 1.000 28.73355 ? 150 GLU   B N   1 
ATOM   3098 C  CA  . GLU   B 1 150 ? -34.24661 -13.81037 64.76358 1.000 29.80262 ? 150 GLU   B CA  1 
ATOM   3099 C  C   . GLU   B 1 150 ? -33.70474 -15.21238 64.51409 1.000 26.09338 ? 150 GLU   B C   1 
ATOM   3100 O  O   . GLU   B 1 150 ? -32.60806 -15.55325 64.97227 1.000 28.92483 ? 150 GLU   B O   1 
ATOM   3101 C  CB  . GLU   B 1 150 ? -35.14796 -13.78773 65.99797 1.000 28.65397 ? 150 GLU   B CB  1 
ATOM   3102 C  CG  . GLU   B 1 150 ? -34.44006 -14.10172 67.30035 1.000 32.63074 ? 150 GLU   B CG  1 
ATOM   3103 C  CD  . GLU   B 1 150 ? -35.01273 -13.32658 68.47001 1.000 33.08240 ? 150 GLU   B CD  1 
ATOM   3104 O  OE1 . GLU   B 1 150 ? -36.22900 -13.04012 68.46276 1.000 36.25483 ? 150 GLU   B OE1 1 
ATOM   3105 O  OE2 . GLU   B 1 150 ? -34.24210 -12.99540 69.39394 1.000 30.83894 ? 150 GLU   B OE2 1 
ATOM   3106 N  N   . ASP   B 1 151 ? -34.45308 -16.03367 63.77196 1.000 25.55666 ? 151 ASP   B N   1 
ATOM   3107 C  CA  . ASP   B 1 151 ? -34.01008 -17.39625 63.49443 1.000 25.98287 ? 151 ASP   B CA  1 
ATOM   3108 C  C   . ASP   B 1 151 ? -32.77635 -17.42380 62.60554 1.000 28.22822 ? 151 ASP   B C   1 
ATOM   3109 O  O   . ASP   B 1 151 ? -32.01020 -18.39324 62.63990 1.000 29.37385 ? 151 ASP   B O   1 
ATOM   3110 C  CB  . ASP   B 1 151 ? -35.13381 -18.20124 62.84219 1.000 27.12361 ? 151 ASP   B CB  1 
ATOM   3111 C  CG  . ASP   B 1 151 ? -36.27997 -18.47641 63.79154 1.000 32.44101 ? 151 ASP   B CG  1 
ATOM   3112 O  OD1 . ASP   B 1 151 ? -36.13819 -18.19308 64.99860 1.000 29.18696 ? 151 ASP   B OD1 1 
ATOM   3113 O  OD2 . ASP   B 1 151 ? -37.32305 -18.98114 63.32872 1.000 37.10781 ? 151 ASP   B OD2 1 
ATOM   3114 N  N   . HIS   B 1 152 ? -32.56778 -16.39053 61.79720 1.000 25.52110 ? 152 HIS   B N   1 
ATOM   3115 C  CA  . HIS   B 1 152 ? -31.42269 -16.37616 60.90097 1.000 23.53850 ? 152 HIS   B CA  1 
ATOM   3116 C  C   . HIS   B 1 152 ? -30.16783 -15.81412 61.55242 1.000 22.86000 ? 152 HIS   B C   1 
ATOM   3117 O  O   . HIS   B 1 152 ? -29.11452 -15.79010 60.91074 1.000 20.43824 ? 152 HIS   B O   1 
ATOM   3118 C  CB  . HIS   B 1 152 ? -31.76624 -15.61190 59.62266 1.000 22.33953 ? 152 HIS   B CB  1 
ATOM   3119 C  CG  . HIS   B 1 152 ? -32.59516 -16.40923 58.66511 1.000 18.72422 ? 152 HIS   B CG  1 
ATOM   3120 N  ND1 . HIS   B 1 152 ? -33.96175 -16.53862 58.79061 1.000 22.87326 ? 152 HIS   B ND1 1 
ATOM   3121 C  CD2 . HIS   B 1 152 ? -32.24445 -17.14991 57.58738 1.000 17.43093 ? 152 HIS   B CD2 1 
ATOM   3122 C  CE1 . HIS   B 1 152 ? -34.41925 -17.30938 57.82012 1.000 17.87351 ? 152 HIS   B CE1 1 
ATOM   3123 N  NE2 . HIS   B 1 152 ? -33.39775 -17.69264 57.07562 1.000 23.77607 ? 152 HIS   B NE2 1 
ATOM   3124 N  N   . TYR   B 1 153 ? -30.24989 -15.37408 62.80481 1.000 20.85554 ? 153 TYR   B N   1 
ATOM   3125 C  CA  . TYR   B 1 153 ? -29.05789 -15.22118 63.62436 1.000 25.49908 ? 153 TYR   B CA  1 
ATOM   3126 C  C   . TYR   B 1 153 ? -28.67266 -16.58177 64.19338 1.000 26.72830 ? 153 TYR   B C   1 
ATOM   3127 O  O   . TYR   B 1 153 ? -29.53785 -17.38535 64.55284 1.000 23.56361 ? 153 TYR   B O   1 
ATOM   3128 C  CB  . TYR   B 1 153 ? -29.29684 -14.21284 64.74937 1.000 19.37927 ? 153 TYR   B CB  1 
ATOM   3129 C  CG  . TYR   B 1 153 ? -29.21825 -12.76676 64.30604 1.000 20.78834 ? 153 TYR   B CG  1 
ATOM   3130 C  CD1 . TYR   B 1 153 ? -28.01231 -12.07869 64.33431 1.000 20.35223 ? 153 TYR   B CD1 1 
ATOM   3131 C  CD2 . TYR   B 1 153 ? -30.34657 -12.09239 63.85510 1.000 18.56498 ? 153 TYR   B CD2 1 
ATOM   3132 C  CE1 . TYR   B 1 153 ? -27.93300 -10.75935 63.93452 1.000 14.20138 ? 153 TYR   B CE1 1 
ATOM   3133 C  CE2 . TYR   B 1 153 ? -30.27552 -10.76983 63.44818 1.000 14.05212 ? 153 TYR   B CE2 1 
ATOM   3134 C  CZ  . TYR   B 1 153 ? -29.06450 -10.10989 63.48811 1.000 17.38110 ? 153 TYR   B CZ  1 
ATOM   3135 O  OH  . TYR   B 1 153 ? -28.98169 -8.79558  63.08543 1.000 15.14919 ? 153 TYR   B OH  1 
ATOM   3136 N  N   . HIS   B 1 154 ? -27.37011 -16.84652 64.25753 1.000 25.49507 ? 154 HIS   B N   1 
ATOM   3137 C  CA  . HIS   B 1 154 ? -26.86481 -18.16705 64.61847 1.000 26.47369 ? 154 HIS   B CA  1 
ATOM   3138 C  C   . HIS   B 1 154 ? -26.80415 -18.30459 66.13585 1.000 24.93313 ? 154 HIS   B C   1 
ATOM   3139 O  O   . HIS   B 1 154 ? -26.15068 -17.50218 66.81136 1.000 25.29102 ? 154 HIS   B O   1 
ATOM   3140 C  CB  . HIS   B 1 154 ? -25.48220 -18.40613 64.01311 1.000 22.84450 ? 154 HIS   B CB  1 
ATOM   3141 C  CG  . HIS   B 1 154 ? -25.45479 -18.38225 62.51611 1.000 25.00125 ? 154 HIS   B CG  1 
ATOM   3142 N  ND1 . HIS   B 1 154 ? -24.44153 -18.96461 61.78539 1.000 21.73313 ? 154 HIS   B ND1 1 
ATOM   3143 C  CD2 . HIS   B 1 154 ? -26.30569 -17.84016 61.61290 1.000 22.52711 ? 154 HIS   B CD2 1 
ATOM   3144 C  CE1 . HIS   B 1 154 ? -24.67219 -18.78738 60.49694 1.000 21.51240 ? 154 HIS   B CE1 1 
ATOM   3145 N  NE2 . HIS   B 1 154 ? -25.79695 -18.10762 60.36510 1.000 20.43316 ? 154 HIS   B NE2 1 
ATOM   3146 N  N   . ALA   B 1 155 ? -27.46638 -19.33366 66.66686 1.000 29.06029 ? 155 ALA   B N   1 
ATOM   3147 C  CA  . ALA   B 1 155 ? -27.47572 -19.56916 68.10506 1.000 34.16191 ? 155 ALA   B CA  1 
ATOM   3148 C  C   . ALA   B 1 155 ? -26.20272 -20.23286 68.61509 1.000 30.89094 ? 155 ALA   B C   1 
ATOM   3149 O  O   . ALA   B 1 155 ? -26.00234 -20.28667 69.83316 1.000 36.07240 ? 155 ALA   B O   1 
ATOM   3150 C  CB  . ALA   B 1 155 ? -28.68417 -20.42343 68.49370 1.000 31.08082 ? 155 ALA   B CB  1 
ATOM   3151 N  N   . ASP   B 1 156 ? -25.34715 -20.74437 67.72876 1.000 32.12165 ? 156 ASP   B N   1 
ATOM   3152 C  CA  . ASP   B 1 156 ? -24.06988 -21.32393 68.12286 1.000 28.77734 ? 156 ASP   B CA  1 
ATOM   3153 C  C   . ASP   B 1 156 ? -22.91449 -20.34479 67.95106 1.000 32.56245 ? 156 ASP   B C   1 
ATOM   3154 O  O   . ASP   B 1 156 ? -21.75010 -20.75920 67.94470 1.000 24.19762 ? 156 ASP   B O   1 
ATOM   3155 C  CB  . ASP   B 1 156 ? -23.79912 -22.60922 67.33827 1.000 23.94381 ? 156 ASP   B CB  1 
ATOM   3156 C  CG  . ASP   B 1 156 ? -23.66843 -22.37094 65.84689 1.000 29.71163 ? 156 ASP   B CG  1 
ATOM   3157 O  OD1 . ASP   B 1 156 ? -24.14358 -21.32343 65.36037 1.000 30.93639 ? 156 ASP   B OD1 1 
ATOM   3158 O  OD2 . ASP   B 1 156 ? -23.08893 -23.23684 65.15837 1.000 35.15984 ? 156 ASP   B OD2 1 
ATOM   3159 N  N   . VAL   B 1 157 ? -23.21634 -19.05791 67.80709 1.000 26.94333 ? 157 VAL   B N   1 
ATOM   3160 C  CA  . VAL   B 1 157 ? -22.21591 -18.00394 67.69621 1.000 22.60915 ? 157 VAL   B CA  1 
ATOM   3161 C  C   . VAL   B 1 157 ? -22.28635 -17.16123 68.96254 1.000 26.30799 ? 157 VAL   B C   1 
ATOM   3162 O  O   . VAL   B 1 157 ? -23.36594 -16.69320 69.34458 1.000 26.09999 ? 157 VAL   B O   1 
ATOM   3163 C  CB  . VAL   B 1 157 ? -22.43839 -17.15581 66.43214 1.000 27.87654 ? 157 VAL   B CB  1 
ATOM   3164 C  CG1 . VAL   B 1 157 ? -21.53730 -15.94681 66.43650 1.000 25.04664 ? 157 VAL   B CG1 1 
ATOM   3165 C  CG2 . VAL   B 1 157 ? -22.17872 -17.99514 65.19123 1.000 20.97958 ? 157 VAL   B CG2 1 
ATOM   3166 N  N   . ALA   B 1 158 ? -21.13417 -16.96822 69.61138 1.000 21.13420 ? 158 ALA   B N   1 
ATOM   3167 C  CA  . ALA   B 1 158 ? -21.12754 -16.46327 70.98246 1.000 20.69108 ? 158 ALA   B CA  1 
ATOM   3168 C  C   . ALA   B 1 158 ? -21.51128 -14.98947 71.05618 1.000 22.07805 ? 158 ALA   B C   1 
ATOM   3169 O  O   . ALA   B 1 158 ? -22.23690 -14.58156 71.97050 1.000 19.96256 ? 158 ALA   B O   1 
ATOM   3170 C  CB  . ALA   B 1 158 ? -19.75688 -16.68987 71.61905 1.000 23.26544 ? 158 ALA   B CB  1 
ATOM   3171 N  N   . TYR   B 1 159 ? -21.02803 -14.16916 70.12368 1.000 20.02338 ? 159 TYR   B N   1 
ATOM   3172 C  CA  . TYR   B 1 159 ? -21.29806 -12.73678 70.15909 1.000 19.63641 ? 159 TYR   B CA  1 
ATOM   3173 C  C   . TYR   B 1 159 ? -22.30624 -12.31040 69.09970 1.000 18.24819 ? 159 TYR   B C   1 
ATOM   3174 O  O   . TYR   B 1 159 ? -23.35182 -11.74721 69.43392 1.000 21.58091 ? 159 TYR   B O   1 
ATOM   3175 C  CB  . TYR   B 1 159 ? -19.99388 -11.93871 70.00328 1.000 15.93417 ? 159 TYR   B CB  1 
ATOM   3176 C  CG  . TYR   B 1 159 ? -20.17799 -10.44090 70.12767 1.000 16.20148 ? 159 TYR   B CG  1 
ATOM   3177 C  CD1 . TYR   B 1 159 ? -20.47321 -9.65937  69.01596 1.000 16.00151 ? 159 TYR   B CD1 1 
ATOM   3178 C  CD2 . TYR   B 1 159 ? -20.06132 -9.80957  71.35858 1.000 22.47825 ? 159 TYR   B CD2 1 
ATOM   3179 C  CE1 . TYR   B 1 159 ? -20.64667 -8.29372  69.12863 1.000 20.36808 ? 159 TYR   B CE1 1 
ATOM   3180 C  CE2 . TYR   B 1 159 ? -20.23072 -8.44420  71.48064 1.000 19.23616 ? 159 TYR   B CE2 1 
ATOM   3181 C  CZ  . TYR   B 1 159 ? -20.52309 -7.69136  70.36268 1.000 21.62574 ? 159 TYR   B CZ  1 
ATOM   3182 O  OH  . TYR   B 1 159 ? -20.69352 -6.33112  70.47808 1.000 17.69917 ? 159 TYR   B OH  1 
ATOM   3183 N  N   . HIS   B 1 160 ? -22.02020 -12.55786 67.82125 1.000 17.11001 ? 160 HIS   B N   1 
ATOM   3184 C  CA  . HIS   B 1 160 ? -22.83699 -12.02082 66.73223 1.000 15.27320 ? 160 HIS   B CA  1 
ATOM   3185 C  C   . HIS   B 1 160 ? -24.08294 -12.88681 66.54100 1.000 18.03061 ? 160 HIS   B C   1 
ATOM   3186 O  O   . HIS   B 1 160 ? -24.25360 -13.60255 65.55158 1.000 18.80529 ? 160 HIS   B O   1 
ATOM   3187 C  CB  . HIS   B 1 160 ? -22.00812 -11.90641 65.46221 1.000 14.42117 ? 160 HIS   B CB  1 
ATOM   3188 C  CG  . HIS   B 1 160 ? -20.97716 -10.82424 65.52625 1.000 15.66535 ? 160 HIS   B CG  1 
ATOM   3189 N  ND1 . HIS   B 1 160 ? -19.63500 -11.08078 65.70619 1.000 14.60929 ? 160 HIS   B ND1 1 
ATOM   3190 C  CD2 . HIS   B 1 160 ? -21.09834 -9.47699  65.46815 1.000 13.57235 ? 160 HIS   B CD2 1 
ATOM   3191 C  CE1 . HIS   B 1 160 ? -18.97168 -9.93856  65.73845 1.000 15.41436 ? 160 HIS   B CE1 1 
ATOM   3192 N  NE2 . HIS   B 1 160 ? -19.83646 -8.95021  65.59705 1.000 14.84102 ? 160 HIS   B NE2 1 
ATOM   3193 N  N   . ASN   B 1 161 ? -24.97401 -12.79006 67.52168 1.000 19.21025 ? 161 ASN   B N   1 
ATOM   3194 C  CA  . ASN   B 1 161 ? -26.21594 -13.55203 67.53293 1.000 22.52974 ? 161 ASN   B CA  1 
ATOM   3195 C  C   . ASN   B 1 161 ? -27.37644 -12.58553 67.76268 1.000 15.87834 ? 161 ASN   B C   1 
ATOM   3196 O  O   . ASN   B 1 161 ? -27.24925 -11.36201 67.62640 1.000 19.57225 ? 161 ASN   B O   1 
ATOM   3197 C  CB  . ASN   B 1 161 ? -26.14690 -14.66163 68.59073 1.000 23.17016 ? 161 ASN   B CB  1 
ATOM   3198 C  CG  . ASN   B 1 161 ? -25.83148 -14.12981 69.97884 1.000 19.77630 ? 161 ASN   B CG  1 
ATOM   3199 O  OD1 . ASN   B 1 161 ? -26.48447 -13.20904 70.47181 1.000 21.64467 ? 161 ASN   B OD1 1 
ATOM   3200 N  ND2 . ASN   B 1 161 ? -24.81669 -14.70499 70.61261 1.000 19.58899 ? 161 ASN   B ND2 1 
ATOM   3201 N  N   . ASN   B 1 162 ? -28.53148 -13.13638 68.14210 1.000 19.96617 ? 162 ASN   B N   1 
ATOM   3202 C  CA  . ASN   B 1 162 ? -29.74011 -12.33406 68.29031 1.000 19.94492 ? 162 ASN   B CA  1 
ATOM   3203 C  C   . ASN   B 1 162 ? -29.70849 -11.43247 69.51835 1.000 21.76283 ? 162 ASN   B C   1 
ATOM   3204 O  O   . ASN   B 1 162 ? -30.44431 -10.44045 69.55682 1.000 23.23022 ? 162 ASN   B O   1 
ATOM   3205 C  CB  . ASN   B 1 162 ? -30.96363 -13.24811 68.34863 1.000 20.41021 ? 162 ASN   B CB  1 
ATOM   3206 C  CG  . ASN   B 1 162 ? -30.83367 -14.32162 69.40851 1.000 26.60665 ? 162 ASN   B CG  1 
ATOM   3207 O  OD1 . ASN   B 1 162 ? -29.75168 -14.86840 69.62243 1.000 27.07380 ? 162 ASN   B OD1 1 
ATOM   3208 N  ND2 . ASN   B 1 162 ? -31.93682 -14.62762 70.08167 1.000 29.55262 ? 162 ASN   B ND2 1 
ATOM   3209 N  N   . ILE   B 1 163 ? -28.88968 -11.75020 70.52356 1.000 15.64751 ? 163 ILE   B N   1 
ATOM   3210 C  CA  . ILE   B 1 163 ? -28.79169 -10.87017 71.68446 1.000 20.47080 ? 163 ILE   B CA  1 
ATOM   3211 C  C   . ILE   B 1 163 ? -28.05075 -9.59235  71.31767 1.000 18.65492 ? 163 ILE   B C   1 
ATOM   3212 O  O   . ILE   B 1 163 ? -28.42641 -8.49444  71.74683 1.000 19.99385 ? 163 ILE   B O   1 
ATOM   3213 C  CB  . ILE   B 1 163 ? -28.11515 -11.59399 72.86190 1.000 22.25936 ? 163 ILE   B CB  1 
ATOM   3214 C  CG1 . ILE   B 1 163 ? -28.73932 -12.97185 73.07775 1.000 20.62779 ? 163 ILE   B CG1 1 
ATOM   3215 C  CG2 . ILE   B 1 163 ? -28.23180 -10.76203 74.13029 1.000 19.61910 ? 163 ILE   B CG2 1 
ATOM   3216 C  CD1 . ILE   B 1 163 ? -28.13470 -13.72971 74.23821 1.000 20.78568 ? 163 ILE   B CD1 1 
ATOM   3217 N  N   . HIS   B 1 164 ? -26.98280 -9.71464  70.52519 1.000 18.48252 ? 164 HIS   B N   1 
ATOM   3218 C  CA  . HIS   B 1 164 ? -26.28007 -8.53189  70.04081 1.000 20.60289 ? 164 HIS   B CA  1 
ATOM   3219 C  C   . HIS   B 1 164 ? -27.18676 -7.67801  69.16424 1.000 16.47325 ? 164 HIS   B C   1 
ATOM   3220 O  O   . HIS   B 1 164 ? -27.17542 -6.44585  69.26277 1.000 19.52455 ? 164 HIS   B O   1 
ATOM   3221 C  CB  . HIS   B 1 164 ? -25.02364 -8.94743  69.27503 1.000 15.90922 ? 164 HIS   B CB  1 
ATOM   3222 C  CG  . HIS   B 1 164 ? -24.34097 -7.81666  68.57010 1.000 13.76399 ? 164 HIS   B CG  1 
ATOM   3223 N  ND1 . HIS   B 1 164 ? -23.73491 -6.77627  69.24156 1.000 17.20279 ? 164 HIS   B ND1 1 
ATOM   3224 C  CD2 . HIS   B 1 164 ? -24.16621 -7.56542  67.25115 1.000 16.12036 ? 164 HIS   B CD2 1 
ATOM   3225 C  CE1 . HIS   B 1 164 ? -23.21502 -5.93397  68.36658 1.000 13.45394 ? 164 HIS   B CE1 1 
ATOM   3226 N  NE2 . HIS   B 1 164 ? -23.46467 -6.38856  67.15173 1.000 13.73497 ? 164 HIS   B NE2 1 
ATOM   3227 N  N   . ALA   B 1 165 ? -27.98394 -8.31702  68.30401 1.000 17.95127 ? 165 ALA   B N   1 
ATOM   3228 C  CA  . ALA   B 1 165 ? -28.92658 -7.57777  67.46962 1.000 19.60013 ? 165 ALA   B CA  1 
ATOM   3229 C  C   . ALA   B 1 165 ? -29.94413 -6.83202  68.32318 1.000 21.59607 ? 165 ALA   B C   1 
ATOM   3230 O  O   . ALA   B 1 165 ? -30.19085 -5.63794  68.11619 1.000 23.56614 ? 165 ALA   B O   1 
ATOM   3231 C  CB  . ALA   B 1 165 ? -29.62982 -8.53046  66.50324 1.000 15.66047 ? 165 ALA   B CB  1 
ATOM   3232 N  N   . ALA   B 1 166 ? -30.54880 -7.52667  69.29039 1.000 25.09238 ? 166 ALA   B N   1 
ATOM   3233 C  CA  . ALA   B 1 166 ? -31.48373 -6.87239  70.19946 1.000 24.29656 ? 166 ALA   B CA  1 
ATOM   3234 C  C   . ALA   B 1 166 ? -30.81257 -5.72912  70.94760 1.000 23.65639 ? 166 ALA   B C   1 
ATOM   3235 O  O   . ALA   B 1 166 ? -31.42356 -4.67734  71.17105 1.000 28.34741 ? 166 ALA   B O   1 
ATOM   3236 C  CB  . ALA   B 1 166 ? -32.05578 -7.89102  71.18458 1.000 24.35640 ? 166 ALA   B CB  1 
ATOM   3237 N  N   . ASP   B 1 167 ? -29.54728 -5.91391  71.32922 1.000 24.16386 ? 167 ASP   B N   1 
ATOM   3238 C  CA  . ASP   B 1 167 ? -28.84042 -4.89515  72.09719 1.000 20.35473 ? 167 ASP   B CA  1 
ATOM   3239 C  C   . ASP   B 1 167 ? -28.55164 -3.65969  71.25270 1.000 26.39743 ? 167 ASP   B C   1 
ATOM   3240 O  O   . ASP   B 1 167 ? -28.66085 -2.52937  71.74187 1.000 21.01628 ? 167 ASP   B O   1 
ATOM   3241 C  CB  . ASP   B 1 167 ? -27.54673 -5.48063  72.66266 1.000 24.75579 ? 167 ASP   B CB  1 
ATOM   3242 C  CG  . ASP   B 1 167 ? -26.68689 -4.44180  73.35211 1.000 25.31579 ? 167 ASP   B CG  1 
ATOM   3243 O  OD1 . ASP   B 1 167 ? -27.22577 -3.66396  74.16691 1.000 26.08077 ? 167 ASP   B OD1 1 
ATOM   3244 O  OD2 . ASP   B 1 167 ? -25.46777 -4.40677  73.08002 1.000 23.54054 ? 167 ASP   B OD2 1 
ATOM   3245 N  N   . VAL   B 1 168 ? -28.17803 -3.85064  69.98533 1.000 24.19939 ? 168 VAL   B N   1 
ATOM   3246 C  CA  . VAL   B 1 168 ? -27.91420 -2.70592  69.11813 1.000 22.01806 ? 168 VAL   B CA  1 
ATOM   3247 C  C   . VAL   B 1 168 ? -29.21272 -1.98209  68.78359 1.000 20.45868 ? 168 VAL   B C   1 
ATOM   3248 O  O   . VAL   B 1 168 ? -29.24516 -0.74844  68.68875 1.000 23.97351 ? 168 VAL   B O   1 
ATOM   3249 C  CB  . VAL   B 1 168 ? -27.16622 -3.15380  67.84948 1.000 18.39045 ? 168 VAL   B CB  1 
ATOM   3250 C  CG1 . VAL   B 1 168 ? -26.94041 -1.97280  66.91967 1.000 21.33517 ? 168 VAL   B CG1 1 
ATOM   3251 C  CG2 . VAL   B 1 168 ? -25.83907 -3.78397  68.22194 1.000 20.01643 ? 168 VAL   B CG2 1 
ATOM   3252 N  N   . VAL   B 1 169 ? -30.30092 -2.73486  68.60196 1.000 19.51353 ? 169 VAL   B N   1 
ATOM   3253 C  CA  . VAL   B 1 169 ? -31.61201 -2.12421  68.39474 1.000 25.14638 ? 169 VAL   B CA  1 
ATOM   3254 C  C   . VAL   B 1 169 ? -31.95739 -1.20339  69.55576 1.000 27.64460 ? 169 VAL   B C   1 
ATOM   3255 O  O   . VAL   B 1 169 ? -32.27228 -0.02234  69.36571 1.000 29.04635 ? 169 VAL   B O   1 
ATOM   3256 C  CB  . VAL   B 1 169 ? -32.68504 -3.21133  68.20951 1.000 23.48906 ? 169 VAL   B CB  1 
ATOM   3257 C  CG1 . VAL   B 1 169 ? -34.06336 -2.65887  68.53193 1.000 28.75018 ? 169 VAL   B CG1 1 
ATOM   3258 C  CG2 . VAL   B 1 169 ? -32.65219 -3.73623  66.80312 1.000 21.62286 ? 169 VAL   B CG2 1 
ATOM   3259 N  N   . GLN   B 1 170 ? -31.89618 -1.73316  70.77847 1.000 30.33240 ? 170 GLN   B N   1 
ATOM   3260 C  CA  . GLN   B 1 170 ? -32.28066 -0.94980  71.94608 1.000 28.55252 ? 170 GLN   B CA  1 
ATOM   3261 C  C   . GLN   B 1 170 ? -31.34319 0.23315   72.14930 1.000 30.71412 ? 170 GLN   B C   1 
ATOM   3262 O  O   . GLN   B 1 170 ? -31.77602 1.31279   72.56948 1.000 30.85242 ? 170 GLN   B O   1 
ATOM   3263 C  CB  . GLN   B 1 170 ? -32.30624 -1.84724  73.18405 1.000 31.05755 ? 170 GLN   B CB  1 
ATOM   3264 C  CG  . GLN   B 1 170 ? -32.91130 -1.20288  74.41941 1.000 31.93765 ? 170 GLN   B CG  1 
ATOM   3265 C  CD  . GLN   B 1 170 ? -31.87078 -0.55322  75.30837 1.000 36.65682 ? 170 GLN   B CD  1 
ATOM   3266 O  OE1 . GLN   B 1 170 ? -30.71556 -0.97730  75.34349 1.000 30.77927 ? 170 GLN   B OE1 1 
ATOM   3267 N  NE2 . GLN   B 1 170 ? -32.27509 0.48377   76.03177 1.000 35.87052 ? 170 GLN   B NE2 1 
ATOM   3268 N  N   . SER   B 1 171 ? -30.05613 0.05404   71.84282 1.000 26.47362 ? 171 SER   B N   1 
ATOM   3269 C  CA  . SER   B 1 171 ? -29.09878 1.14104   72.01963 1.000 22.91947 ? 171 SER   B CA  1 
ATOM   3270 C  C   . SER   B 1 171 ? -29.32490 2.25017   70.99849 1.000 30.61591 ? 171 SER   B C   1 
ATOM   3271 O  O   . SER   B 1 171 ? -29.27745 3.43663   71.34415 1.000 25.78015 ? 171 SER   B O   1 
ATOM   3272 C  CB  . SER   B 1 171 ? -27.67207 0.60180   71.92854 1.000 26.73156 ? 171 SER   B CB  1 
ATOM   3273 O  OG  . SER   B 1 171 ? -27.43899 -0.39425  72.90938 1.000 23.74917 ? 171 SER   B OG  1 
ATOM   3274 N  N   . THR   B 1 172 ? -29.56395 1.88492   69.73546 1.000 29.35268 ? 172 THR   B N   1 
ATOM   3275 C  CA  . THR   B 1 172 ? -29.92609 2.88116   68.73091 1.000 29.56219 ? 172 THR   B CA  1 
ATOM   3276 C  C   . THR   B 1 172 ? -31.19676 3.62039   69.12967 1.000 28.92837 ? 172 THR   B C   1 
ATOM   3277 O  O   . THR   B 1 172 ? -31.29172 4.84402   68.97252 1.000 32.11595 ? 172 THR   B O   1 
ATOM   3278 C  CB  . THR   B 1 172 ? -30.10514 2.21010   67.36740 1.000 30.93357 ? 172 THR   B CB  1 
ATOM   3279 O  OG1 . THR   B 1 172 ? -28.83679 1.74961   66.88569 1.000 23.73764 ? 172 THR   B OG1 1 
ATOM   3280 C  CG2 . THR   B 1 172 ? -30.70568 3.18218   66.36140 1.000 27.83204 ? 172 THR   B CG2 1 
ATOM   3281 N  N   . HIS   B 1 173 ? -32.17880 2.88674   69.65932 1.000 27.99870 ? 173 HIS   B N   1 
ATOM   3282 C  CA  . HIS   B 1 173 ? -33.43117 3.48502   70.10959 1.000 33.91825 ? 173 HIS   B CA  1 
ATOM   3283 C  C   . HIS   B 1 173 ? -33.20088 4.58336   71.13992 1.000 38.31941 ? 173 HIS   B C   1 
ATOM   3284 O  O   . HIS   B 1 173 ? -33.95089 5.56627   71.17710 1.000 35.62141 ? 173 HIS   B O   1 
ATOM   3285 C  CB  . HIS   B 1 173 ? -34.33144 2.38505   70.67721 1.000 29.94312 ? 173 HIS   B CB  1 
ATOM   3286 C  CG  . HIS   B 1 173 ? -35.44354 2.88305   71.54732 1.000 46.46290 ? 173 HIS   B CG  1 
ATOM   3287 N  ND1 . HIS   B 1 173 ? -36.74524 2.97947   71.10621 1.000 41.67682 ? 173 HIS   B ND1 1 
ATOM   3288 C  CD2 . HIS   B 1 173 ? -35.45557 3.28018   72.84207 1.000 44.71520 ? 173 HIS   B CD2 1 
ATOM   3289 C  CE1 . HIS   B 1 173 ? -37.50811 3.43067   72.08548 1.000 47.96405 ? 173 HIS   B CE1 1 
ATOM   3290 N  NE2 . HIS   B 1 173 ? -36.74951 3.62324   73.14924 1.000 50.37902 ? 173 HIS   B NE2 1 
ATOM   3291 N  N   . VAL   B 1 174 ? -32.17795 4.43631   71.98270 1.000 32.77472 ? 174 VAL   B N   1 
ATOM   3292 C  CA  . VAL   B 1 174 ? -31.89785 5.44581   72.99807 1.000 32.35422 ? 174 VAL   B CA  1 
ATOM   3293 C  C   . VAL   B 1 174 ? -31.12774 6.61533   72.40068 1.000 33.42059 ? 174 VAL   B C   1 
ATOM   3294 O  O   . VAL   B 1 174 ? -31.44230 7.78056   72.66920 1.000 34.79761 ? 174 VAL   B O   1 
ATOM   3295 C  CB  . VAL   B 1 174 ? -31.14389 4.81143   74.18038 1.000 31.82949 ? 174 VAL   B CB  1 
ATOM   3296 C  CG1 . VAL   B 1 174 ? -30.43945 5.88162   74.99845 1.000 27.09957 ? 174 VAL   B CG1 1 
ATOM   3297 C  CG2 . VAL   B 1 174 ? -32.10402 4.02046   75.05067 1.000 27.18290 ? 174 VAL   B CG2 1 
ATOM   3298 N  N   . LEU   B 1 175 ? -30.11352 6.32915   71.58088 1.000 31.09032 ? 175 LEU   B N   1 
ATOM   3299 C  CA  . LEU   B 1 175 ? -29.36771 7.39446   70.92344 1.000 34.01412 ? 175 LEU   B CA  1 
ATOM   3300 C  C   . LEU   B 1 175 ? -30.25505 8.24808   70.02841 1.000 35.42256 ? 175 LEU   B C   1 
ATOM   3301 O  O   . LEU   B 1 175 ? -29.90501 9.39668   69.74662 1.000 32.49801 ? 175 LEU   B O   1 
ATOM   3302 C  CB  . LEU   B 1 175 ? -28.21679 6.80365   70.11074 1.000 31.47478 ? 175 LEU   B CB  1 
ATOM   3303 C  CG  . LEU   B 1 175 ? -27.19268 6.00549   70.91933 1.000 30.56850 ? 175 LEU   B CG  1 
ATOM   3304 C  CD1 . LEU   B 1 175 ? -26.09130 5.48224   70.01731 1.000 25.76099 ? 175 LEU   B CD1 1 
ATOM   3305 C  CD2 . LEU   B 1 175 ? -26.61447 6.85231   72.04516 1.000 28.50638 ? 175 LEU   B CD2 1 
ATOM   3306 N  N   . LEU   B 1 176 ? -31.39445 7.71808   69.57906 1.000 35.17600 ? 176 LEU   B N   1 
ATOM   3307 C  CA  . LEU   B 1 176 ? -32.35354 8.50145   68.80971 1.000 36.69583 ? 176 LEU   B CA  1 
ATOM   3308 C  C   . LEU   B 1 176 ? -33.12232 9.50520   69.66892 1.000 40.18936 ? 176 LEU   B C   1 
ATOM   3309 O  O   . LEU   B 1 176 ? -33.93418 10.26007  69.11320 1.000 39.57335 ? 176 LEU   B O   1 
ATOM   3310 C  CB  . LEU   B 1 176 ? -33.34268 7.57548   68.10180 1.000 31.81425 ? 176 LEU   B CB  1 
ATOM   3311 C  CG  . LEU   B 1 176 ? -32.91619 6.90100   66.79571 1.000 38.23847 ? 176 LEU   B CG  1 
ATOM   3312 C  CD1 . LEU   B 1 176 ? -33.98069 5.91710   66.34549 1.000 34.33157 ? 176 LEU   B CD1 1 
ATOM   3313 C  CD2 . LEU   B 1 176 ? -32.67172 7.94749   65.72248 1.000 34.79318 ? 176 LEU   B CD2 1 
ATOM   3314 N  N   . SER   B 1 177 ? -32.89520 9.53305   70.98861 1.000 37.22791 ? 177 SER   B N   1 
ATOM   3315 C  CA  . SER   B 1 177 ? -33.62775 10.41471  71.88920 1.000 34.42084 ? 177 SER   B CA  1 
ATOM   3316 C  C   . SER   B 1 177 ? -32.74313 11.36316  72.67781 1.000 35.80657 ? 177 SER   B C   1 
ATOM   3317 O  O   . SER   B 1 177 ? -33.25681 12.08240  73.54644 1.000 43.99279 ? 177 SER   B O   1 
ATOM   3318 C  CB  . SER   B 1 177 ? -34.48355 9.60557   72.86406 1.000 32.71753 ? 177 SER   B CB  1 
ATOM   3319 O  OG  . SER   B 1 177 ? -35.46355 8.85539   72.16520 1.000 41.34933 ? 177 SER   B OG  1 
ATOM   3320 N  N   . THR   B 1 178 ? -31.44637 11.33780  72.43799 1.000 36.24867 ? 178 THR   B N   1 
ATOM   3321 C  CA  . THR   B 1 178 ? -30.60475 12.44126  72.84300 1.000 40.87083 ? 178 THR   B CA  1 
ATOM   3322 C  C   . THR   B 1 178 ? -31.32618 13.75737  72.60414 1.000 49.85825 ? 178 THR   B C   1 
ATOM   3323 O  O   . THR   B 1 178 ? -31.81429 13.99481  71.50960 1.000 49.66446 ? 178 THR   B O   1 
ATOM   3324 C  CB  . THR   B 1 178 ? -29.32722 12.42866  72.03111 1.000 39.76410 ? 178 THR   B CB  1 
ATOM   3325 O  OG1 . THR   B 1 178 ? -28.87064 11.05448  71.86503 1.000 52.18025 ? 178 THR   B OG1 1 
ATOM   3326 C  CG2 . THR   B 1 178 ? -28.30915 13.23458  72.69489 1.000 46.26536 ? 178 THR   B CG2 1 
ATOM   3327 N  N   . PRO   B 1 179 ? -31.44236 14.60592  73.62046 1.000 50.09030 ? 179 PRO   B N   1 
ATOM   3328 C  CA  . PRO   B 1 179 ? -32.06574 15.92593  73.42066 1.000 45.50681 ? 179 PRO   B CA  1 
ATOM   3329 C  C   . PRO   B 1 179 ? -31.46492 16.73744  72.27837 1.000 44.61462 ? 179 PRO   B C   1 
ATOM   3330 O  O   . PRO   B 1 179 ? -32.21906 17.40192  71.56306 1.000 44.32003 ? 179 PRO   B O   1 
ATOM   3331 C  CB  . PRO   B 1 179 ? -31.85920 16.60958  74.79194 1.000 46.82297 ? 179 PRO   B CB  1 
ATOM   3332 C  CG  . PRO   B 1 179 ? -31.98740 15.45133  75.74493 1.000 48.90766 ? 179 PRO   B CG  1 
ATOM   3333 C  CD  . PRO   B 1 179 ? -31.31644 14.28977  75.06139 1.000 44.71086 ? 179 PRO   B CD  1 
ATOM   3334 N  N   . ALA   B 1 180 ? -30.14804 16.66551  72.05282 1.000 42.14659 ? 180 ALA   B N   1 
ATOM   3335 C  CA  . ALA   B 1 180 ? -29.52551 17.49560  71.02278 1.000 48.87094 ? 180 ALA   B CA  1 
ATOM   3336 C  C   . ALA   B 1 180 ? -29.88592 17.05673  69.60624 1.000 49.82650 ? 180 ALA   B C   1 
ATOM   3337 O  O   . ALA   B 1 180 ? -29.58858 17.79110  68.65362 1.000 47.73898 ? 180 ALA   B O   1 
ATOM   3338 C  CB  . ALA   B 1 180 ? -28.00104 17.50265  71.18945 1.000 44.09715 ? 180 ALA   B CB  1 
ATOM   3339 N  N   . LEU   B 1 181 ? -30.51074 15.88887  69.44714 1.000 51.34950 ? 181 LEU   B N   1 
ATOM   3340 C  CA  . LEU   B 1 181 ? -30.98240 15.45930  68.14326 1.000 50.79186 ? 181 LEU   B CA  1 
ATOM   3341 C  C   . LEU   B 1 181 ? -32.44679 15.72229  67.88954 1.000 44.01222 ? 181 LEU   B C   1 
ATOM   3342 O  O   . LEU   B 1 181 ? -32.91370 15.40272  66.79966 1.000 43.85678 ? 181 LEU   B O   1 
ATOM   3343 C  CB  . LEU   B 1 181 ? -30.79906 13.95111  67.94142 1.000 40.76854 ? 181 LEU   B CB  1 
ATOM   3344 C  CG  . LEU   B 1 181 ? -29.48836 13.33025  67.50865 1.000 49.54557 ? 181 LEU   B CG  1 
ATOM   3345 C  CD1 . LEU   B 1 181 ? -28.20922 14.13567  67.75068 1.000 46.32229 ? 181 LEU   B CD1 1 
ATOM   3346 C  CD2 . LEU   B 1 181 ? -29.44015 11.99662  68.20570 1.000 46.07853 ? 181 LEU   B CD2 1 
ATOM   3347 N  N   . GLU   B 1 182 ? -33.19760 16.25641  68.83984 1.000 47.00887 ? 182 GLU   B N   1 
ATOM   3348 C  CA  . GLU   B 1 182 ? -34.63467 16.26429  68.62370 1.000 49.97840 ? 182 GLU   B CA  1 
ATOM   3349 C  C   . GLU   B 1 182 ? -35.00261 17.20239  67.47633 1.000 44.60241 ? 182 GLU   B C   1 
ATOM   3350 O  O   . GLU   B 1 182 ? -34.35850 18.23048  67.24565 1.000 46.28989 ? 182 GLU   B O   1 
ATOM   3351 C  CB  . GLU   B 1 182 ? -35.37778 16.60997  69.91441 1.000 47.76193 ? 182 GLU   B CB  1 
ATOM   3352 C  CG  . GLU   B 1 182 ? -35.40617 15.43862  70.90903 1.000 55.48278 ? 182 GLU   B CG  1 
ATOM   3353 C  CD  . GLU   B 1 182 ? -36.07358 14.16858  70.36068 1.000 59.93529 ? 182 GLU   B CD  1 
ATOM   3354 O  OE1 . GLU   B 1 182 ? -36.07969 13.15284  71.07627 1.000 59.48438 ? 182 GLU   B OE1 1 
ATOM   3355 O  OE2 . GLU   B 1 182 ? -36.60496 14.16749  69.23590 1.000 56.93582 ? 182 GLU   B OE2 1 
ATOM   3356 N  N   . ALA   B 1 183 ? -36.00652 16.78089  66.70533 1.000 43.87663 ? 183 ALA   B N   1 
ATOM   3357 C  CA  . ALA   B 1 183 ? -36.44570 17.40670  65.46129 1.000 45.81759 ? 183 ALA   B CA  1 
ATOM   3358 C  C   . ALA   B 1 183 ? -35.45840 17.22498  64.31257 1.000 47.51130 ? 183 ALA   B C   1 
ATOM   3359 O  O   . ALA   B 1 183 ? -35.62191 17.86292  63.26499 1.000 42.99028 ? 183 ALA   B O   1 
ATOM   3360 C  CB  . ALA   B 1 183 ? -36.73179 18.90080  65.64423 1.000 39.11674 ? 183 ALA   B CB  1 
ATOM   3361 N  N   . VAL   B 1 184 ? -34.44377 16.37548  64.46212 1.000 44.11119 ? 184 VAL   B N   1 
ATOM   3362 C  CA  . VAL   B 1 184 ? -33.44503 16.21637  63.40469 1.000 44.23997 ? 184 VAL   B CA  1 
ATOM   3363 C  C   . VAL   B 1 184 ? -33.84231 15.12860  62.41195 1.000 39.07800 ? 184 VAL   B C   1 
ATOM   3364 O  O   . VAL   B 1 184 ? -33.61458 15.27070  61.20822 1.000 43.63876 ? 184 VAL   B O   1 
ATOM   3365 C  CB  . VAL   B 1 184 ? -32.05348 15.94322  64.01655 1.000 43.67876 ? 184 VAL   B CB  1 
ATOM   3366 C  CG1 . VAL   B 1 184 ? -31.07357 15.46920  62.95951 1.000 34.83895 ? 184 VAL   B CG1 1 
ATOM   3367 C  CG2 . VAL   B 1 184 ? -31.52133 17.19418  64.69876 1.000 47.91829 ? 184 VAL   B CG2 1 
ATOM   3368 N  N   . PHE   B 1 185 ? -34.44938 14.03862  62.87345 1.000 36.73784 ? 185 PHE   B N   1 
ATOM   3369 C  CA  . PHE   B 1 185 ? -34.76357 12.90604  62.01330 1.000 36.22141 ? 185 PHE   B CA  1 
ATOM   3370 C  C   . PHE   B 1 185 ? -36.26856 12.74451  61.85123 1.000 36.38534 ? 185 PHE   B C   1 
ATOM   3371 O  O   . PHE   B 1 185 ? -37.02456 12.86608  62.81991 1.000 40.53539 ? 185 PHE   B O   1 
ATOM   3372 C  CB  . PHE   B 1 185 ? -34.16573 11.60975  62.56705 1.000 37.15703 ? 185 PHE   B CB  1 
ATOM   3373 C  CG  . PHE   B 1 185 ? -32.67872 11.65954  62.74475 1.000 32.20876 ? 185 PHE   B CG  1 
ATOM   3374 C  CD1 . PHE   B 1 185 ? -31.84248 11.79239  61.64898 1.000 31.57857 ? 185 PHE   B CD1 1 
ATOM   3375 C  CD2 . PHE   B 1 185 ? -32.11525 11.56559  64.00565 1.000 27.50445 ? 185 PHE   B CD2 1 
ATOM   3376 C  CE1 . PHE   B 1 185 ? -30.47346 11.84189  61.80813 1.000 33.41552 ? 185 PHE   B CE1 1 
ATOM   3377 C  CE2 . PHE   B 1 185 ? -30.74629 11.61072  64.17115 1.000 30.95180 ? 185 PHE   B CE2 1 
ATOM   3378 C  CZ  . PHE   B 1 185 ? -29.92488 11.74896  63.07052 1.000 32.89451 ? 185 PHE   B CZ  1 
ATOM   3379 N  N   . THR   B 1 186 ? -36.69627 12.45935  60.62318 1.000 38.38790 ? 186 THR   B N   1 
ATOM   3380 C  CA  . THR   B 1 186 ? -38.09680 12.17266  60.36175 1.000 43.18917 ? 186 THR   B CA  1 
ATOM   3381 C  C   . THR   B 1 186 ? -38.43467 10.75306  60.81284 1.000 40.41102 ? 186 THR   B C   1 
ATOM   3382 O  O   . THR   B 1 186 ? -37.56476 9.97376   61.21074 1.000 45.38456 ? 186 THR   B O   1 
ATOM   3383 C  CB  . THR   B 1 186 ? -38.42123 12.34884  58.87699 1.000 45.04873 ? 186 THR   B CB  1 
ATOM   3384 O  OG1 . THR   B 1 186 ? -37.86545 11.25879  58.12969 1.000 44.00950 ? 186 THR   B OG1 1 
ATOM   3385 C  CG2 . THR   B 1 186 ? -37.84271 13.65444  58.35632 1.000 39.60068 ? 186 THR   B CG2 1 
ATOM   3386 N  N   . ASP   B 1 187 ? -39.72511 10.41639  60.74009 1.000 37.36116 ? 187 ASP   B N   1 
ATOM   3387 C  CA  . ASP   B 1 187 ? -40.16763 9.09871   61.18502 1.000 33.81353 ? 187 ASP   B CA  1 
ATOM   3388 C  C   . ASP   B 1 187 ? -39.61972 7.98678   60.29969 1.000 43.06185 ? 187 ASP   B C   1 
ATOM   3389 O  O   . ASP   B 1 187 ? -39.36258 6.88014   60.78750 1.000 42.35223 ? 187 ASP   B O   1 
ATOM   3390 C  CB  . ASP   B 1 187 ? -41.69419 9.03746   61.22249 1.000 35.47352 ? 187 ASP   B CB  1 
ATOM   3391 C  CG  . ASP   B 1 187 ? -42.29955 10.11948  62.09362 1.000 51.65377 ? 187 ASP   B CG  1 
ATOM   3392 O  OD1 . ASP   B 1 187 ? -41.53266 10.85116  62.75459 1.000 47.67287 ? 187 ASP   B OD1 1 
ATOM   3393 O  OD2 . ASP   B 1 187 ? -43.54333 10.23258  62.12312 1.000 54.49422 ? 187 ASP   B OD2 1 
ATOM   3394 N  N   . LEU   B 1 188 ? -39.44101 8.25238   59.00369 1.000 36.45556 ? 188 LEU   B N   1 
ATOM   3395 C  CA  . LEU   B 1 188 ? -38.88028 7.23569   58.11996 1.000 41.67896 ? 188 LEU   B CA  1 
ATOM   3396 C  C   . LEU   B 1 188 ? -37.40686 7.00364   58.42277 1.000 35.83158 ? 188 LEU   B C   1 
ATOM   3397 O  O   . LEU   B 1 188 ? -36.93121 5.86255   58.39531 1.000 33.21210 ? 188 LEU   B O   1 
ATOM   3398 C  CB  . LEU   B 1 188 ? -39.07117 7.64185   56.65944 1.000 33.51584 ? 188 LEU   B CB  1 
ATOM   3399 C  CG  . LEU   B 1 188 ? -38.90590 6.52653   55.62605 1.000 35.95744 ? 188 LEU   B CG  1 
ATOM   3400 C  CD1 . LEU   B 1 188 ? -40.05714 5.53646   55.72478 1.000 29.88402 ? 188 LEU   B CD1 1 
ATOM   3401 C  CD2 . LEU   B 1 188 ? -38.80566 7.10191   54.22195 1.000 28.66713 ? 188 LEU   B CD2 1 
ATOM   3402 N  N   . GLU   B 1 189 ? -36.66937 8.07537   58.71433 1.000 33.29021 ? 189 GLU   B N   1 
ATOM   3403 C  CA  . GLU   B 1 189 ? -35.27638 7.92355   59.11331 1.000 31.24859 ? 189 GLU   B CA  1 
ATOM   3404 C  C   . GLU   B 1 189 ? -35.15480 7.17970   60.43301 1.000 35.77859 ? 189 GLU   B C   1 
ATOM   3405 O  O   . GLU   B 1 189 ? -34.18985 6.43549   60.64061 1.000 33.42952 ? 189 GLU   B O   1 
ATOM   3406 C  CB  . GLU   B 1 189 ? -34.62179 9.29370   59.21061 1.000 37.19834 ? 189 GLU   B CB  1 
ATOM   3407 C  CG  . GLU   B 1 189 ? -34.98591 10.17350  58.05199 1.000 38.99979 ? 189 GLU   B CG  1 
ATOM   3408 C  CD  . GLU   B 1 189 ? -34.19651 11.44280  58.03803 1.000 41.16816 ? 189 GLU   B CD  1 
ATOM   3409 O  OE1 . GLU   B 1 189 ? -34.29671 12.20180  59.02036 1.000 41.82864 ? 189 GLU   B OE1 1 
ATOM   3410 O  OE2 . GLU   B 1 189 ? -33.48778 11.69581  57.04265 1.000 40.01204 ? 189 GLU   B OE2 1 
ATOM   3411 N  N   . ILE   B 1 190 ? -36.12068 7.36781   61.33296 1.000 36.51754 ? 190 ILE   B N   1 
ATOM   3412 C  CA  . ILE   B 1 190 ? -36.11215 6.64532   62.59954 1.000 39.64005 ? 190 ILE   B CA  1 
ATOM   3413 C  C   . ILE   B 1 190 ? -36.40023 5.16611   62.37239 1.000 36.43688 ? 190 ILE   B C   1 
ATOM   3414 O  O   . ILE   B 1 190 ? -35.73025 4.29504   62.94099 1.000 38.25194 ? 190 ILE   B O   1 
ATOM   3415 C  CB  . ILE   B 1 190 ? -37.11481 7.28860   63.57486 1.000 34.00163 ? 190 ILE   B CB  1 
ATOM   3416 C  CG1 . ILE   B 1 190 ? -36.52363 8.57695   64.15333 1.000 37.90824 ? 190 ILE   B CG1 1 
ATOM   3417 C  CG2 . ILE   B 1 190 ? -37.50356 6.31503   64.68000 1.000 29.81934 ? 190 ILE   B CG2 1 
ATOM   3418 C  CD1 . ILE   B 1 190 ? -37.55496 9.56375   64.65184 1.000 43.05658 ? 190 ILE   B CD1 1 
ATOM   3419 N  N   . LEU   B 1 191 ? -37.39415 4.85686   61.53427 1.000 33.17183 ? 191 LEU   B N   1 
ATOM   3420 C  CA  . LEU   B 1 191 ? -37.66295 3.46496   61.18678 1.000 34.19869 ? 191 LEU   B CA  1 
ATOM   3421 C  C   . LEU   B 1 191 ? -36.47346 2.82992   60.47803 1.000 35.37306 ? 191 LEU   B C   1 
ATOM   3422 O  O   . LEU   B 1 191 ? -36.24365 1.62176   60.60865 1.000 30.97229 ? 191 LEU   B O   1 
ATOM   3423 C  CB  . LEU   B 1 191 ? -38.91478 3.37742   60.31176 1.000 31.11930 ? 191 LEU   B CB  1 
ATOM   3424 C  CG  . LEU   B 1 191 ? -39.35759 1.99185   59.83446 1.000 32.54825 ? 191 LEU   B CG  1 
ATOM   3425 C  CD1 . LEU   B 1 191 ? -39.96429 1.19024   60.97718 1.000 29.46634 ? 191 LEU   B CD1 1 
ATOM   3426 C  CD2 . LEU   B 1 191 ? -40.33497 2.10737   58.67232 1.000 36.34199 ? 191 LEU   B CD2 1 
ATOM   3427 N  N   . ALA   B 1 192 ? -35.70337 3.62850   59.73481 1.000 35.43276 ? 192 ALA   B N   1 
ATOM   3428 C  CA  . ALA   B 1 192 ? -34.53684 3.10468   59.03166 1.000 33.31559 ? 192 ALA   B CA  1 
ATOM   3429 C  C   . ALA   B 1 192 ? -33.45750 2.65992   60.00668 1.000 28.05278 ? 192 ALA   B C   1 
ATOM   3430 O  O   . ALA   B 1 192 ? -32.99424 1.51507   59.95395 1.000 29.61130 ? 192 ALA   B O   1 
ATOM   3431 C  CB  . ALA   B 1 192 ? -33.98572 4.15811   58.07001 1.000 22.57797 ? 192 ALA   B CB  1 
ATOM   3432 N  N   . ALA   B 1 193 ? -33.04041 3.55951   60.90162 1.000 28.13758 ? 193 ALA   B N   1 
ATOM   3433 C  CA  . ALA   B 1 193 ? -31.98695 3.23299   61.85636 1.000 31.54232 ? 193 ALA   B CA  1 
ATOM   3434 C  C   . ALA   B 1 193 ? -32.35541 2.03221   62.71737 1.000 25.64313 ? 193 ALA   B C   1 
ATOM   3435 O  O   . ALA   B 1 193 ? -31.47275 1.27371   63.13446 1.000 27.33775 ? 193 ALA   B O   1 
ATOM   3436 C  CB  . ALA   B 1 193 ? -31.68838 4.44592   62.73768 1.000 34.83102 ? 193 ALA   B CB  1 
ATOM   3437 N  N   . ILE   B 1 194 ? -33.64649 1.83456   62.97988 1.000 25.76617 ? 194 ILE   B N   1 
ATOM   3438 C  CA  . ILE   B 1 194 ? -34.07963 0.74777   63.85122 1.000 27.49821 ? 194 ILE   B CA  1 
ATOM   3439 C  C   . ILE   B 1 194 ? -34.11113 -0.57416  63.09478 1.000 26.99891 ? 194 ILE   B C   1 
ATOM   3440 O  O   . ILE   B 1 194 ? -33.58208 -1.58751  63.56664 1.000 21.97045 ? 194 ILE   B O   1 
ATOM   3441 C  CB  . ILE   B 1 194 ? -35.44860 1.08500   64.46881 1.000 30.90354 ? 194 ILE   B CB  1 
ATOM   3442 C  CG1 . ILE   B 1 194 ? -35.29181 2.18427   65.52225 1.000 32.53767 ? 194 ILE   B CG1 1 
ATOM   3443 C  CG2 . ILE   B 1 194 ? -36.09495 -0.15851  65.05992 1.000 26.65707 ? 194 ILE   B CG2 1 
ATOM   3444 C  CD1 . ILE   B 1 194 ? -36.60248 2.72162   66.04308 1.000 31.96552 ? 194 ILE   B CD1 1 
ATOM   3445 N  N   . PHE   B 1 195 ? -34.73889 -0.58639  61.91531 1.000 19.53668 ? 195 PHE   B N   1 
ATOM   3446 C  CA  . PHE   B 1 195 ? -34.73377 -1.78700  61.08461 1.000 22.72109 ? 195 PHE   B CA  1 
ATOM   3447 C  C   . PHE   B 1 195 ? -33.31278 -2.18241  60.70384 1.000 20.36182 ? 195 PHE   B C   1 
ATOM   3448 O  O   . PHE   B 1 195 ? -32.96865 -3.37069  60.70850 1.000 17.93548 ? 195 PHE   B O   1 
ATOM   3449 C  CB  . PHE   B 1 195 ? -35.58855 -1.56047  59.83545 1.000 21.45108 ? 195 PHE   B CB  1 
ATOM   3450 C  CG  . PHE   B 1 195 ? -35.56834 -2.70756  58.86056 1.000 20.66755 ? 195 PHE   B CG  1 
ATOM   3451 C  CD1 . PHE   B 1 195 ? -36.37507 -3.81715  59.05637 1.000 19.52002 ? 195 PHE   B CD1 1 
ATOM   3452 C  CD2 . PHE   B 1 195 ? -34.75691 -2.66570  57.73753 1.000 19.22616 ? 195 PHE   B CD2 1 
ATOM   3453 C  CE1 . PHE   B 1 195 ? -36.36264 -4.86897  58.15785 1.000 20.97257 ? 195 PHE   B CE1 1 
ATOM   3454 C  CE2 . PHE   B 1 195 ? -34.73997 -3.71364  56.83570 1.000 15.69486 ? 195 PHE   B CE2 1 
ATOM   3455 C  CZ  . PHE   B 1 195 ? -35.54391 -4.81652  57.04599 1.000 21.04531 ? 195 PHE   B CZ  1 
ATOM   3456 N  N   . ALA   B 1 196 ? -32.47144 -1.19712  60.37763 1.000 19.74851 ? 196 ALA   B N   1 
ATOM   3457 C  CA  . ALA   B 1 196 ? -31.07601 -1.48415  60.06054 1.000 20.98710 ? 196 ALA   B CA  1 
ATOM   3458 C  C   . ALA   B 1 196 ? -30.36764 -2.12332  61.24694 1.000 21.87854 ? 196 ALA   B C   1 
ATOM   3459 O  O   . ALA   B 1 196 ? -29.66020 -3.12528  61.09429 1.000 20.06094 ? 196 ALA   B O   1 
ATOM   3460 C  CB  . ALA   B 1 196 ? -30.35780 -0.20498  59.63015 1.000 20.72539 ? 196 ALA   B CB  1 
ATOM   3461 N  N   . SER   B 1 197 ? -30.55288 -1.55591  62.44307 1.000 19.59012 ? 197 SER   B N   1 
ATOM   3462 C  CA  . SER   B 1 197 ? -29.95755 -2.13339  63.64436 1.000 19.90701 ? 197 SER   B CA  1 
ATOM   3463 C  C   . SER   B 1 197 ? -30.37754 -3.58583  63.82692 1.000 18.75989 ? 197 SER   B C   1 
ATOM   3464 O  O   . SER   B 1 197 ? -29.58185 -4.42127  64.27075 1.000 17.42710 ? 197 SER   B O   1 
ATOM   3465 C  CB  . SER   B 1 197 ? -30.35312 -1.31284  64.87446 1.000 15.62912 ? 197 SER   B CB  1 
ATOM   3466 O  OG  . SER   B 1 197 ? -29.77414 -0.02043  64.84657 1.000 23.59490 ? 197 SER   B OG  1 
ATOM   3467 N  N   . ALA   B 1 198 ? -31.62198 -3.90875  63.46805 1.000 20.43030 ? 198 ALA   B N   1 
ATOM   3468 C  CA  . ALA   B 1 198 ? -32.15150 -5.24091  63.74018 1.000 17.60124 ? 198 ALA   B CA  1 
ATOM   3469 C  C   . ALA   B 1 198 ? -31.55428 -6.28731  62.80978 1.000 19.07470 ? 198 ALA   B C   1 
ATOM   3470 O  O   . ALA   B 1 198 ? -31.34152 -7.43570  63.21608 1.000 18.02581 ? 198 ALA   B O   1 
ATOM   3471 C  CB  . ALA   B 1 198 ? -33.67541 -5.22980  63.62923 1.000 19.79183 ? 198 ALA   B CB  1 
ATOM   3472 N  N   . ILE   B 1 199 ? -31.28222 -5.91576  61.55731 1.000 14.51467 ? 199 ILE   B N   1 
ATOM   3473 C  CA  . ILE   B 1 199 ? -30.78103 -6.85891  60.56509 1.000 17.93680 ? 199 ILE   B CA  1 
ATOM   3474 C  C   . ILE   B 1 199 ? -29.27309 -6.78181  60.38970 1.000 14.02632 ? 199 ILE   B C   1 
ATOM   3475 O  O   . ILE   B 1 199 ? -28.71628 -7.53235  59.57661 1.000 15.55482 ? 199 ILE   B O   1 
ATOM   3476 C  CB  . ILE   B 1 199 ? -31.46577 -6.63488  59.20243 1.000 17.01760 ? 199 ILE   B CB  1 
ATOM   3477 C  CG1 . ILE   B 1 199 ? -30.98331 -5.31840  58.58720 1.000 14.28621 ? 199 ILE   B CG1 1 
ATOM   3478 C  CG2 . ILE   B 1 199 ? -32.97901 -6.62981  59.35755 1.000 15.72095 ? 199 ILE   B CG2 1 
ATOM   3479 C  CD1 . ILE   B 1 199 ? -31.31659 -5.16919  57.11775 1.000 15.02895 ? 199 ILE   B CD1 1 
ATOM   3480 N  N   . HIS   B 1 200 ? -28.59093 -5.91074  61.13633 1.000 15.21764 ? 200 HIS   B N   1 
ATOM   3481 C  CA  . HIS   B 1 200 ? -27.24597 -5.48509  60.76201 1.000 13.77255 ? 200 HIS   B CA  1 
ATOM   3482 C  C   . HIS   B 1 200 ? -26.19077 -6.57813  60.89041 1.000 12.63046 ? 200 HIS   B C   1 
ATOM   3483 O  O   . HIS   B 1 200 ? -25.08709 -6.39992  60.36562 1.000 12.40709 ? 200 HIS   B O   1 
ATOM   3484 C  CB  . HIS   B 1 200 ? -26.83218 -4.26706  61.59288 1.000 13.70430 ? 200 HIS   B CB  1 
ATOM   3485 C  CG  . HIS   B 1 200 ? -26.12273 -4.60765  62.86563 1.000 15.73155 ? 200 HIS   B CG  1 
ATOM   3486 N  ND1 . HIS   B 1 200 ? -26.78868 -4.90537  64.03520 1.000 12.66970 ? 200 HIS   B ND1 1 
ATOM   3487 C  CD2 . HIS   B 1 200 ? -24.80229 -4.67905  63.15582 1.000 12.41256 ? 200 HIS   B CD2 1 
ATOM   3488 C  CE1 . HIS   B 1 200 ? -25.90877 -5.15452  64.98859 1.000 14.66139 ? 200 HIS   B CE1 1 
ATOM   3489 N  NE2 . HIS   B 1 200 ? -24.69641 -5.02439  64.48095 1.000 12.66863 ? 200 HIS   B NE2 1 
ATOM   3490 N  N   . ASP   B 1 201 ? -26.48425 -7.69217  61.56576 1.000 15.13208 ? 201 ASP   B N   1 
ATOM   3491 C  CA  . ASP   B 1 201 ? -25.53621 -8.79851  61.65677 1.000 15.43759 ? 201 ASP   B CA  1 
ATOM   3492 C  C   . ASP   B 1 201 ? -26.18397 -10.13710 61.32664 1.000 16.23564 ? 201 ASP   B C   1 
ATOM   3493 O  O   . ASP   B 1 201 ? -25.64861 -11.18358 61.70606 1.000 13.77628 ? 201 ASP   B O   1 
ATOM   3494 C  CB  . ASP   B 1 201 ? -24.89846 -8.86975  63.04756 1.000 12.14755 ? 201 ASP   B CB  1 
ATOM   3495 C  CG  . ASP   B 1 201 ? -23.71863 -7.93376  63.20068 1.000 14.61908 ? 201 ASP   B CG  1 
ATOM   3496 O  OD1 . ASP   B 1 201 ? -23.05895 -7.62891  62.18516 1.000 13.82157 ? 201 ASP   B OD1 1 
ATOM   3497 O  OD2 . ASP   B 1 201 ? -23.44203 -7.51532  64.34367 1.000 13.50961 ? 201 ASP   B OD2 1 
ATOM   3498 N  N   . VAL   B 1 202 ? -27.32452 -10.12980 60.63290 1.000 14.55388 ? 202 VAL   B N   1 
ATOM   3499 C  CA  . VAL   B 1 202 ? -28.08325 -11.36089 60.45557 1.000 15.19057 ? 202 VAL   B CA  1 
ATOM   3500 C  C   . VAL   B 1 202 ? -27.27113 -12.36456 59.64599 1.000 14.74742 ? 202 VAL   B C   1 
ATOM   3501 O  O   . VAL   B 1 202 ? -26.55545 -12.00609 58.70016 1.000 14.97854 ? 202 VAL   B O   1 
ATOM   3502 C  CB  . VAL   B 1 202 ? -29.44751 -11.06492 59.80758 1.000 14.77034 ? 202 VAL   B CB  1 
ATOM   3503 C  CG1 . VAL   B 1 202 ? -29.28937 -10.64217 58.35692 1.000 15.39173 ? 202 VAL   B CG1 1 
ATOM   3504 C  CG2 . VAL   B 1 202 ? -30.36790 -12.27082 59.92710 1.000 19.74070 ? 202 VAL   B CG2 1 
ATOM   3505 N  N   . ASP   B 1 203 ? -27.35471 -13.63395 60.05299 1.000 17.74724 ? 203 ASP   B N   1 
ATOM   3506 C  CA  . ASP   B 1 203 ? -26.63819 -14.74307 59.42674 1.000 13.47209 ? 203 ASP   B CA  1 
ATOM   3507 C  C   . ASP   B 1 203 ? -25.12266 -14.60151 59.56120 1.000 14.34327 ? 203 ASP   B C   1 
ATOM   3508 O  O   . ASP   B 1 203 ? -24.37021 -15.06512 58.70112 1.000 15.93950 ? 203 ASP   B O   1 
ATOM   3509 C  CB  . ASP   B 1 203 ? -27.03946 -14.90558 57.95605 1.000 12.54260 ? 203 ASP   B CB  1 
ATOM   3510 C  CG  . ASP   B 1 203 ? -26.84998 -16.32124 57.45498 1.000 15.30666 ? 203 ASP   B CG  1 
ATOM   3511 O  OD1 . ASP   B 1 203 ? -27.03580 -17.26498 58.25148 1.000 17.80370 ? 203 ASP   B OD1 1 
ATOM   3512 O  OD2 . ASP   B 1 203 ? -26.51613 -16.48971 56.26473 1.000 12.90356 ? 203 ASP   B OD2 1 
ATOM   3513 N  N   . HIS   B 1 204 ? -24.66612 -13.97725 60.64164 1.000 12.87282 ? 204 HIS   B N   1 
ATOM   3514 C  CA  . HIS   B 1 204 ? -23.23221 -13.84194 60.88288 1.000 15.58182 ? 204 HIS   B CA  1 
ATOM   3515 C  C   . HIS   B 1 204 ? -22.63697 -15.20512 61.22302 1.000 15.81630 ? 204 HIS   B C   1 
ATOM   3516 O  O   . HIS   B 1 204 ? -23.12569 -15.87674 62.13923 1.000 14.85770 ? 204 HIS   B O   1 
ATOM   3517 C  CB  . HIS   B 1 204 ? -22.97781 -12.85284 62.02049 1.000 12.29313 ? 204 HIS   B CB  1 
ATOM   3518 C  CG  . HIS   B 1 204 ? -21.61492 -12.23265 61.99527 1.000 13.90998 ? 204 HIS   B CG  1 
ATOM   3519 N  ND1 . HIS   B 1 204 ? -20.45806 -12.96791 62.14015 1.000 14.23739 ? 204 HIS   B ND1 1 
ATOM   3520 C  CD2 . HIS   B 1 204 ? -21.22555 -10.94309 61.85456 1.000 11.83903 ? 204 HIS   B CD2 1 
ATOM   3521 C  CE1 . HIS   B 1 204 ? -19.41470 -12.15958 62.08207 1.000 15.41673 ? 204 HIS   B CE1 1 
ATOM   3522 N  NE2 . HIS   B 1 204 ? -19.85309 -10.92546 61.91017 1.000 14.39197 ? 204 HIS   B NE2 1 
ATOM   3523 N  N   . PRO   B 1 205 ? -21.59879 -15.65341 60.51232 1.000 18.62715 ? 205 PRO   B N   1 
ATOM   3524 C  CA  . PRO   B 1 205 ? -21.01244 -16.97084 60.79182 1.000 17.85752 ? 205 PRO   B CA  1 
ATOM   3525 C  C   . PRO   B 1 205 ? -20.05191 -16.99937 61.97025 1.000 23.15970 ? 205 PRO   B C   1 
ATOM   3526 O  O   . PRO   B 1 205 ? -19.57598 -18.08320 62.32803 1.000 22.65293 ? 205 PRO   B O   1 
ATOM   3527 C  CB  . PRO   B 1 205 ? -20.27779 -17.29599 59.48403 1.000 16.24335 ? 205 PRO   B CB  1 
ATOM   3528 C  CG  . PRO   B 1 205 ? -19.88633 -15.96332 58.95118 1.000 20.38342 ? 205 PRO   B CG  1 
ATOM   3529 C  CD  . PRO   B 1 205 ? -21.02007 -15.03518 59.30783 1.000 15.26633 ? 205 PRO   B CD  1 
ATOM   3530 N  N   . GLY   B 1 206 ? -19.75113 -15.85654 62.57904 1.000 19.42244 ? 206 GLY   B N   1 
ATOM   3531 C  CA  . GLY   B 1 206 ? -18.83454 -15.80832 63.69784 1.000 18.62373 ? 206 GLY   B CA  1 
ATOM   3532 C  C   . GLY   B 1 206 ? -17.38036 -15.62063 63.33353 1.000 21.95976 ? 206 GLY   B C   1 
ATOM   3533 O  O   . GLY   B 1 206 ? -16.51395 -15.82214 64.19310 1.000 18.26665 ? 206 GLY   B O   1 
ATOM   3534 N  N   . VAL   B 1 207 ? -17.08137 -15.25087 62.08773 1.000 15.70838 ? 207 VAL   B N   1 
ATOM   3535 C  CA  . VAL   B 1 207 ? -15.71895 -14.99578 61.64461 1.000 19.16037 ? 207 VAL   B CA  1 
ATOM   3536 C  C   . VAL   B 1 207 ? -15.68426 -13.65114 60.93013 1.000 20.25029 ? 207 VAL   B C   1 
ATOM   3537 O  O   . VAL   B 1 207 ? -16.71190 -13.11583 60.50903 1.000 21.33014 ? 207 VAL   B O   1 
ATOM   3538 C  CB  . VAL   B 1 207 ? -15.17911 -16.11235 60.72546 1.000 21.62340 ? 207 VAL   B CB  1 
ATOM   3539 C  CG1 . VAL   B 1 207 ? -15.12150 -17.43896 61.47187 1.000 20.49541 ? 207 VAL   B CG1 1 
ATOM   3540 C  CG2 . VAL   B 1 207 ? -16.03790 -16.23323 59.47766 1.000 18.58128 ? 207 VAL   B CG2 1 
ATOM   3541 N  N   . SER   B 1 208 ? -14.47627 -13.11099 60.79183 1.000 18.01633 ? 208 SER   B N   1 
ATOM   3542 C  CA  . SER   B 1 208 ? -14.29305 -11.76984 60.26092 1.000 21.05197 ? 208 SER   B CA  1 
ATOM   3543 C  C   . SER   B 1 208 ? -14.33671 -11.77176 58.73337 1.000 16.80835 ? 208 SER   B C   1 
ATOM   3544 O  O   . SER   B 1 208 ? -14.23790 -12.81305 58.07733 1.000 16.63378 ? 208 SER   B O   1 
ATOM   3545 C  CB  . SER   B 1 208 ? -12.96929 -11.18041 60.74552 1.000 16.64902 ? 208 SER   B CB  1 
ATOM   3546 O  OG  . SER   B 1 208 ? -11.86629 -11.89035 60.20650 1.000 22.00475 ? 208 SER   B OG  1 
ATOM   3547 N  N   . ASN   B 1 209 ? -14.49272 -10.56914 58.16860 1.000 17.74660 ? 209 ASN   B N   1 
ATOM   3548 C  CA  . ASN   B 1 209 ? -14.39169 -10.40510 56.72120 1.000 18.58396 ? 209 ASN   B CA  1 
ATOM   3549 C  C   . ASN   B 1 209 ? -13.04686 -10.89735 56.20633 1.000 20.66194 ? 209 ASN   B C   1 
ATOM   3550 O  O   . ASN   B 1 209 ? -12.97807 -11.57822 55.17608 1.000 17.16238 ? 209 ASN   B O   1 
ATOM   3551 C  CB  . ASN   B 1 209 ? -14.59268 -8.93789  56.33901 1.000 13.41287 ? 209 ASN   B CB  1 
ATOM   3552 C  CG  . ASN   B 1 209 ? -16.05299 -8.54948  56.24932 1.000 15.39135 ? 209 ASN   B CG  1 
ATOM   3553 O  OD1 . ASN   B 1 209 ? -16.90115 -9.36099  55.88450 1.000 13.63289 ? 209 ASN   B OD1 1 
ATOM   3554 N  ND2 . ASN   B 1 209 ? -16.35292 -7.29765  56.57512 1.000 11.77584 ? 209 ASN   B ND2 1 
ATOM   3555 N  N   . GLN   B 1 210 ? -11.96530 -10.55877 56.91262 1.000 22.66669 ? 210 GLN   B N   1 
ATOM   3556 C  CA  . GLN   B 1 210 ? -10.63508 -10.97688 56.48396 1.000 22.92213 ? 210 GLN   B CA  1 
ATOM   3557 C  C   . GLN   B 1 210 ? -10.51066 -12.49455 56.47565 1.000 24.39227 ? 210 GLN   B C   1 
ATOM   3558 O  O   . GLN   B 1 210 ? -9.88500  -13.06887 55.57655 1.000 24.03513 ? 210 GLN   B O   1 
ATOM   3559 C  CB  . GLN   B 1 210 ? -9.57451  -10.35557 57.39195 1.000 22.63989 ? 210 GLN   B CB  1 
ATOM   3560 C  CG  . GLN   B 1 210 ? -8.17250  -10.39483 56.81400 1.000 30.04426 ? 210 GLN   B CG  1 
ATOM   3561 C  CD  . GLN   B 1 210 ? -8.07130  -9.64933  55.49866 1.000 30.18449 ? 210 GLN   B CD  1 
ATOM   3562 O  OE1 . GLN   B 1 210 ? -8.03123  -8.41952  55.47169 1.000 29.09500 ? 210 GLN   B OE1 1 
ATOM   3563 N  NE2 . GLN   B 1 210 ? -8.03503  -10.39171 54.39763 1.000 28.78921 ? 210 GLN   B NE2 1 
ATOM   3564 N  N   . PHE   B 1 211 ? -11.09597 -13.16073 57.47330 1.000 19.04134 ? 211 PHE   B N   1 
ATOM   3565 C  CA  . PHE   B 1 211 ? -11.12253 -14.61947 57.47713 1.000 18.50705 ? 211 PHE   B CA  1 
ATOM   3566 C  C   . PHE   B 1 211 ? -11.85671 -15.14961 56.25327 1.000 25.81463 ? 211 PHE   B C   1 
ATOM   3567 O  O   . PHE   B 1 211 ? -11.38412 -16.07273 55.58008 1.000 23.37773 ? 211 PHE   B O   1 
ATOM   3568 C  CB  . PHE   B 1 211 ? -11.78096 -15.12595 58.76054 1.000 19.25398 ? 211 PHE   B CB  1 
ATOM   3569 C  CG  . PHE   B 1 211 ? -11.77973 -16.62247 58.89595 1.000 22.09215 ? 211 PHE   B CG  1 
ATOM   3570 C  CD1 . PHE   B 1 211 ? -10.71063 -17.27567 59.48026 1.000 22.08744 ? 211 PHE   B CD1 1 
ATOM   3571 C  CD2 . PHE   B 1 211 ? -12.84758 -17.37653 58.43746 1.000 24.13405 ? 211 PHE   B CD2 1 
ATOM   3572 C  CE1 . PHE   B 1 211 ? -10.71392 -18.64885 59.61519 1.000 28.11183 ? 211 PHE   B CE1 1 
ATOM   3573 C  CE2 . PHE   B 1 211 ? -12.84960 -18.75243 58.56310 1.000 31.38582 ? 211 PHE   B CE2 1 
ATOM   3574 C  CZ  . PHE   B 1 211 ? -11.77808 -19.38914 59.14855 1.000 28.84083 ? 211 PHE   B CZ  1 
ATOM   3575 N  N   . LEU   B 1 212 ? -13.02203 -14.57230 55.95214 1.000 21.60360 ? 212 LEU   B N   1 
ATOM   3576 C  CA  . LEU   B 1 212 ? -13.78003 -14.99466 54.77988 1.000 22.12773 ? 212 LEU   B CA  1 
ATOM   3577 C  C   . LEU   B 1 212 ? -12.99048 -14.75718 53.49984 1.000 21.12885 ? 212 LEU   B C   1 
ATOM   3578 O  O   . LEU   B 1 212 ? -13.03104 -15.57658 52.57467 1.000 20.89180 ? 212 LEU   B O   1 
ATOM   3579 C  CB  . LEU   B 1 212 ? -15.11736 -14.25766 54.73632 1.000 16.97476 ? 212 LEU   B CB  1 
ATOM   3580 C  CG  . LEU   B 1 212 ? -16.06939 -14.60590 55.87966 1.000 20.78258 ? 212 LEU   B CG  1 
ATOM   3581 C  CD1 . LEU   B 1 212 ? -17.14785 -13.55119 56.01711 1.000 18.89050 ? 212 LEU   B CD1 1 
ATOM   3582 C  CD2 . LEU   B 1 212 ? -16.68600 -15.97382 55.64641 1.000 22.77496 ? 212 LEU   B CD2 1 
ATOM   3583 N  N   . ILE   B 1 213 ? -12.25605 -13.64593 53.43438 1.000 21.74227 ? 213 ILE   B N   1 
ATOM   3584 C  CA  . ILE   B 1 213 ? -11.44324 -13.35591 52.25761 1.000 21.81026 ? 213 ILE   B CA  1 
ATOM   3585 C  C   . ILE   B 1 213 ? -10.28591 -14.34233 52.15157 1.000 28.53062 ? 213 ILE   B C   1 
ATOM   3586 O  O   . ILE   B 1 213 ? -10.07576 -14.96738 51.10528 1.000 30.08424 ? 213 ILE   B O   1 
ATOM   3587 C  CB  . ILE   B 1 213 ? -10.94212 -11.90145 52.30072 1.000 22.50567 ? 213 ILE   B CB  1 
ATOM   3588 C  CG1 . ILE   B 1 213 ? -12.11094 -10.92838 52.12924 1.000 15.63166 ? 213 ILE   B CG1 1 
ATOM   3589 C  CG2 . ILE   B 1 213 ? -9.87949  -11.67345 51.23717 1.000 23.86592 ? 213 ILE   B CG2 1 
ATOM   3590 C  CD1 . ILE   B 1 213 ? -11.76446 -9.49129  52.45327 1.000 17.20831 ? 213 ILE   B CD1 1 
ATOM   3591 N  N   . ASN   B 1 214 ? -9.52477  -14.50466 53.23840 1.000 28.95523 ? 214 ASN   B N   1 
ATOM   3592 C  CA  . ASN   B 1 214 ? -8.34076  -15.35850 53.21274 1.000 30.27825 ? 214 ASN   B CA  1 
ATOM   3593 C  C   . ASN   B 1 214 ? -8.67431  -16.82477 52.97133 1.000 32.63400 ? 214 ASN   B C   1 
ATOM   3594 O  O   . ASN   B 1 214 ? -7.77946  -17.59921 52.61472 1.000 32.81445 ? 214 ASN   B O   1 
ATOM   3595 C  CB  . ASN   B 1 214 ? -7.56483  -15.22746 54.52474 1.000 25.44909 ? 214 ASN   B CB  1 
ATOM   3596 C  CG  . ASN   B 1 214 ? -6.97896  -13.84539 54.72185 1.000 27.92360 ? 214 ASN   B CG  1 
ATOM   3597 O  OD1 . ASN   B 1 214 ? -6.86352  -13.06604 53.77626 1.000 34.01655 ? 214 ASN   B OD1 1 
ATOM   3598 N  ND2 . ASN   B 1 214 ? -6.59868  -13.53544 55.95644 1.000 34.93510 ? 214 ASN   B ND2 1 
ATOM   3599 N  N   . THR   B 1 215 ? -9.92950  -17.22587 53.16249 1.000 27.89924 ? 215 THR   B N   1 
ATOM   3600 C  CA  . THR   B 1 215 ? -10.34313 -18.61309 53.00586 1.000 25.24667 ? 215 THR   B CA  1 
ATOM   3601 C  C   . THR   B 1 215 ? -11.03383 -18.87823 51.67834 1.000 23.73939 ? 215 THR   B C   1 
ATOM   3602 O  O   . THR   B 1 215 ? -11.51187 -19.99610 51.45727 1.000 30.60114 ? 215 THR   B O   1 
ATOM   3603 C  CB  . THR   B 1 215 ? -11.27146 -19.02413 54.14915 1.000 28.12203 ? 215 THR   B CB  1 
ATOM   3604 O  OG1 . THR   B 1 215 ? -12.26357 -18.01079 54.35437 1.000 29.33359 ? 215 THR   B OG1 1 
ATOM   3605 C  CG2 . THR   B 1 215 ? -10.49136 -19.20382 55.41352 1.000 29.25780 ? 215 THR   B CG2 1 
ATOM   3606 N  N   . ASN   B 1 216 ? -11.10112 -17.87981 50.79849 1.000 29.77768 ? 216 ASN   B N   1 
ATOM   3607 C  CA  . ASN   B 1 216 ? -11.79136 -18.00255 49.51757 1.000 30.52272 ? 216 ASN   B CA  1 
ATOM   3608 C  C   . ASN   B 1 216 ? -13.20953 -18.52706 49.72553 1.000 25.75712 ? 216 ASN   B C   1 
ATOM   3609 O  O   . ASN   B 1 216 ? -13.67657 -19.44273 49.04411 1.000 26.52105 ? 216 ASN   B O   1 
ATOM   3610 C  CB  . ASN   B 1 216 ? -10.99746 -18.88560 48.55580 1.000 32.83444 ? 216 ASN   B CB  1 
ATOM   3611 C  CG  . ASN   B 1 216 ? -9.54305  -18.46688 48.45578 1.000 31.17883 ? 216 ASN   B CG  1 
ATOM   3612 O  OD1 . ASN   B 1 216 ? -9.23665  -17.30599 48.18079 1.000 39.64629 ? 216 ASN   B OD1 1 
ATOM   3613 N  ND2 . ASN   B 1 216 ? -8.63823  -19.40853 48.69448 1.000 38.09665 ? 216 ASN   B ND2 1 
ATOM   3614 N  N   . SER   B 1 217 ? -13.88521 -17.94259 50.71010 1.000 26.46804 ? 217 SER   B N   1 
ATOM   3615 C  CA  . SER   B 1 217 ? -15.24898 -18.31913 51.03088 1.000 20.48096 ? 217 SER   B CA  1 
ATOM   3616 C  C   . SER   B 1 217 ? -16.18503 -17.95766 49.88325 1.000 18.62272 ? 217 SER   B C   1 
ATOM   3617 O  O   . SER   B 1 217 ? -15.86493 -17.14263 49.01353 1.000 15.95285 ? 217 SER   B O   1 
ATOM   3618 C  CB  . SER   B 1 217 ? -15.70360 -17.62572 52.31479 1.000 20.44273 ? 217 SER   B CB  1 
ATOM   3619 O  OG  . SER   B 1 217 ? -15.59821 -16.21700 52.19176 1.000 20.33852 ? 217 SER   B OG  1 
ATOM   3620 N  N   . GLU   B 1 218 ? -17.36006 -18.58714 49.88684 1.000 19.27813 ? 218 GLU   B N   1 
ATOM   3621 C  CA  . GLU   B 1 218 ? -18.37123 -18.24805 48.89323 1.000 24.76331 ? 218 GLU   B CA  1 
ATOM   3622 C  C   . GLU   B 1 218 ? -18.87740 -16.82558 49.09563 1.000 19.93408 ? 218 GLU   B C   1 
ATOM   3623 O  O   . GLU   B 1 218 ? -19.18499 -16.12530 48.12396 1.000 18.14692 ? 218 GLU   B O   1 
ATOM   3624 C  CB  . GLU   B 1 218 ? -19.52544 -19.24807 48.95811 1.000 27.19613 ? 218 GLU   B CB  1 
ATOM   3625 C  CG  . GLU   B 1 218 ? -20.37379 -19.30935 47.69695 1.000 37.87374 ? 218 GLU   B CG  1 
ATOM   3626 C  CD  . GLU   B 1 218 ? -19.67616 -20.02325 46.55158 1.000 44.10829 ? 218 GLU   B CD  1 
ATOM   3627 O  OE1 . GLU   B 1 218 ? -18.58864 -20.59674 46.77444 1.000 41.47461 ? 218 GLU   B OE1 1 
ATOM   3628 O  OE2 . GLU   B 1 218 ? -20.21973 -20.01594 45.42671 1.000 51.82390 ? 218 GLU   B OE2 1 
ATOM   3629 N  N   . LEU   B 1 219 ? -18.96152 -16.38116 50.35201 1.000 18.04227 ? 219 LEU   B N   1 
ATOM   3630 C  CA  . LEU   B 1 219 ? -19.39209 -15.01582 50.63677 1.000 18.69276 ? 219 LEU   B CA  1 
ATOM   3631 C  C   . LEU   B 1 219 ? -18.45322 -13.99793 50.00042 1.000 14.48726 ? 219 LEU   B C   1 
ATOM   3632 O  O   . LEU   B 1 219 ? -18.89755 -13.06820 49.31674 1.000 15.08400 ? 219 LEU   B O   1 
ATOM   3633 C  CB  . LEU   B 1 219 ? -19.47485 -14.79779 52.14837 1.000 17.66032 ? 219 LEU   B CB  1 
ATOM   3634 C  CG  . LEU   B 1 219 ? -20.75776 -15.22312 52.86371 1.000 22.68147 ? 219 LEU   B CG  1 
ATOM   3635 C  CD1 . LEU   B 1 219 ? -20.69974 -14.83601 54.33453 1.000 20.88592 ? 219 LEU   B CD1 1 
ATOM   3636 C  CD2 . LEU   B 1 219 ? -21.97013 -14.60160 52.19189 1.000 18.56893 ? 219 LEU   B CD2 1 
ATOM   3637 N  N   . ALA   B 1 220 ? -17.14461 -14.15762 50.21688 1.000 14.05972 ? 220 ALA   B N   1 
ATOM   3638 C  CA  . ALA   B 1 220 ? -16.18371 -13.21868 49.64696 1.000 16.71714 ? 220 ALA   B CA  1 
ATOM   3639 C  C   . ALA   B 1 220 ? -16.12657 -13.32388 48.12869 1.000 16.60881 ? 220 ALA   B C   1 
ATOM   3640 O  O   . ALA   B 1 220 ? -15.89725 -12.31719 47.44816 1.000 13.78988 ? 220 ALA   B O   1 
ATOM   3641 C  CB  . ALA   B 1 220 ? -14.79888 -13.44923 50.25052 1.000 15.73602 ? 220 ALA   B CB  1 
ATOM   3642 N  N   . LEU   B 1 221 ? -16.31913 -14.52742 47.58257 1.000 17.47501 ? 221 LEU   B N   1 
ATOM   3643 C  CA  . LEU   B 1 221 ? -16.44890 -14.66783 46.13615 1.000 16.90168 ? 221 LEU   B CA  1 
ATOM   3644 C  C   . LEU   B 1 221 ? -17.65286 -13.89012 45.62499 1.000 16.03004 ? 221 LEU   B C   1 
ATOM   3645 O  O   . LEU   B 1 221 ? -17.57311 -13.20500 44.59828 1.000 14.33726 ? 221 LEU   B O   1 
ATOM   3646 C  CB  . LEU   B 1 221 ? -16.57195 -16.14515 45.76017 1.000 16.03801 ? 221 LEU   B CB  1 
ATOM   3647 C  CG  . LEU   B 1 221 ? -15.58547 -16.72795 44.74477 1.000 32.71804 ? 221 LEU   B CG  1 
ATOM   3648 C  CD1 . LEU   B 1 221 ? -15.60611 -15.93907 43.44359 1.000 24.10990 ? 221 LEU   B CD1 1 
ATOM   3649 C  CD2 . LEU   B 1 221 ? -14.17963 -16.79002 45.32166 1.000 29.17231 ? 221 LEU   B CD2 1 
ATOM   3650 N  N   . MET   B 1 222 ? -18.77582 -13.97747 46.34082 1.000 15.41245 ? 222 MET   B N   1 
ATOM   3651 C  CA  . MET   B 1 222 ? -19.98581 -13.27727 45.92635 1.000 14.71585 ? 222 MET   B CA  1 
ATOM   3652 C  C   . MET   B 1 222 ? -19.79224 -11.76622 45.94914 1.000 14.13695 ? 222 MET   B C   1 
ATOM   3653 O  O   . MET   B 1 222 ? -20.20376 -11.06678 45.01653 1.000 11.55062 ? 222 MET   B O   1 
ATOM   3654 C  CB  . MET   B 1 222 ? -21.15100 -13.67941 46.83252 1.000 15.63982 ? 222 MET   B CB  1 
ATOM   3655 C  CG  . MET   B 1 222 ? -22.48175 -13.02684 46.48458 1.000 17.66889 ? 222 MET   B CG  1 
ATOM   3656 S  SD  . MET   B 1 222 ? -23.22741 -13.69283 44.98468 1.000 21.25807 ? 222 MET   B SD  1 
ATOM   3657 C  CE  . MET   B 1 222 ? -23.66377 -15.34201 45.53223 1.000 22.37118 ? 222 MET   B CE  1 
ATOM   3658 N  N   . TYR   B 1 223 ? -19.15510 -11.24425 46.99666 1.000 13.56844 ? 223 TYR   B N   1 
ATOM   3659 C  CA  . TYR   B 1 223 ? -19.14399 -9.81055  47.25729 1.000 13.99821 ? 223 TYR   B CA  1 
ATOM   3660 C  C   . TYR   B 1 223 ? -17.79499 -9.15116  47.00004 1.000 15.80343 ? 223 TYR   B C   1 
ATOM   3661 O  O   . TYR   B 1 223 ? -17.59091 -8.00735  47.42189 1.000 12.07856 ? 223 TYR   B O   1 
ATOM   3662 C  CB  . TYR   B 1 223 ? -19.60306 -9.54284  48.68976 1.000 15.53937 ? 223 TYR   B CB  1 
ATOM   3663 C  CG  . TYR   B 1 223 ? -21.07508 -9.81308  48.87157 1.000 15.43778 ? 223 TYR   B CG  1 
ATOM   3664 C  CD1 . TYR   B 1 223 ? -22.02046 -9.03350  48.22062 1.000 12.61798 ? 223 TYR   B CD1 1 
ATOM   3665 C  CD2 . TYR   B 1 223 ? -21.52196 -10.85202 49.67750 1.000 14.97775 ? 223 TYR   B CD2 1 
ATOM   3666 C  CE1 . TYR   B 1 223 ? -23.36862 -9.27310  48.37075 1.000 16.25539 ? 223 TYR   B CE1 1 
ATOM   3667 C  CE2 . TYR   B 1 223 ? -22.87279 -11.09926 49.83677 1.000 16.16675 ? 223 TYR   B CE2 1 
ATOM   3668 C  CZ  . TYR   B 1 223 ? -23.79071 -10.30566 49.18046 1.000 14.63560 ? 223 TYR   B CZ  1 
ATOM   3669 O  OH  . TYR   B 1 223 ? -25.13626 -10.54507 49.33257 1.000 14.28904 ? 223 TYR   B OH  1 
ATOM   3670 N  N   . ASN   B 1 224 ? -16.87540 -9.83891  46.32123 1.000 12.04144 ? 224 ASN   B N   1 
ATOM   3671 C  CA  . ASN   B 1 224 ? -15.64546 -9.22575  45.81293 1.000 12.51203 ? 224 ASN   B CA  1 
ATOM   3672 C  C   . ASN   B 1 224 ? -14.84457 -8.54883  46.92491 1.000 12.59577 ? 224 ASN   B C   1 
ATOM   3673 O  O   . ASN   B 1 224 ? -14.31011 -7.44997  46.75668 1.000 11.76121 ? 224 ASN   B O   1 
ATOM   3674 C  CB  . ASN   B 1 224 ? -15.96189 -8.24143  44.68405 1.000 11.02930 ? 224 ASN   B CB  1 
ATOM   3675 C  CG  . ASN   B 1 224 ? -16.64485 -8.91167  43.50417 1.000 15.77565 ? 224 ASN   B CG  1 
ATOM   3676 O  OD1 . ASN   B 1 224 ? -16.12670 -9.87655  42.94091 1.000 15.82683 ? 224 ASN   B OD1 1 
ATOM   3677 N  ND2 . ASN   B 1 224 ? -17.82154 -8.41452  43.13668 1.000 10.19170 ? 224 ASN   B ND2 1 
ATOM   3678 N  N   . ASP   B 1 225 ? -14.78746 -9.20741  48.08207 1.000 13.82669 ? 225 ASP   B N   1 
ATOM   3679 C  CA  . ASP   B 1 225 ? -13.92885 -8.86036  49.21318 1.000 14.02815 ? 225 ASP   B CA  1 
ATOM   3680 C  C   . ASP   B 1 225 ? -14.27783 -7.52609  49.86760 1.000 15.82472 ? 225 ASP   B C   1 
ATOM   3681 O  O   . ASP   B 1 225 ? -13.53587 -7.06524  50.74323 1.000 17.97940 ? 225 ASP   B O   1 
ATOM   3682 C  CB  . ASP   B 1 225 ? -12.44682 -8.85360  48.81273 1.000 15.20751 ? 225 ASP   B CB  1 
ATOM   3683 C  CG  . ASP   B 1 225 ? -11.97256 -10.19868 48.29779 1.000 17.63607 ? 225 ASP   B CG  1 
ATOM   3684 O  OD1 . ASP   B 1 225 ? -12.65233 -11.21456 48.55353 1.000 20.52131 ? 225 ASP   B OD1 1 
ATOM   3685 O  OD2 . ASP   B 1 225 ? -10.91068 -10.23942 47.64193 1.000 14.79953 ? 225 ASP   B OD2 1 
ATOM   3686 N  N   . SER   B 1 226 ? -15.38291 -6.89098  49.48730 1.000 11.89064 ? 226 SER   B N   1 
ATOM   3687 C  CA  . SER   B 1 226 ? -15.71821 -5.55396  49.96686 1.000 16.14862 ? 226 SER   B CA  1 
ATOM   3688 C  C   . SER   B 1 226 ? -16.95278 -5.62117  50.85547 1.000 18.07056 ? 226 SER   B C   1 
ATOM   3689 O  O   . SER   B 1 226 ? -18.04409 -5.94937  50.37600 1.000 12.19577 ? 226 SER   B O   1 
ATOM   3690 C  CB  . SER   B 1 226 ? -15.95388 -4.60014  48.79645 1.000 16.87130 ? 226 SER   B CB  1 
ATOM   3691 O  OG  . SER   B 1 226 ? -14.99939 -4.80840  47.77034 1.000 30.66417 ? 226 SER   B OG  1 
ATOM   3692 N  N   . SER   B 1 227 ? -16.77764 -5.28533  52.13534 1.000 13.95797 ? 227 SER   B N   1 
ATOM   3693 C  CA  . SER   B 1 227 ? -17.84722 -5.32800  53.13533 1.000 14.62614 ? 227 SER   B CA  1 
ATOM   3694 C  C   . SER   B 1 227 ? -18.67765 -6.59876  52.98340 1.000 13.46002 ? 227 SER   B C   1 
ATOM   3695 O  O   . SER   B 1 227 ? -19.90619 -6.56963  52.88044 1.000 13.68737 ? 227 SER   B O   1 
ATOM   3696 C  CB  . SER   B 1 227 ? -18.72397 -4.07843  53.05518 1.000 15.63062 ? 227 SER   B CB  1 
ATOM   3697 O  OG  . SER   B 1 227 ? -18.00616 -2.92517  53.46266 1.000 15.28873 ? 227 SER   B OG  1 
ATOM   3698 N  N   . VAL   B 1 228 ? -17.97027 -7.73129  52.96509 1.000 13.73127 ? 228 VAL   B N   1 
ATOM   3699 C  CA  . VAL   B 1 228 ? -18.57859 -9.00892  52.59892 1.000 12.23502 ? 228 VAL   B CA  1 
ATOM   3700 C  C   . VAL   B 1 228 ? -19.73085 -9.34752  53.53549 1.000 12.53842 ? 228 VAL   B C   1 
ATOM   3701 O  O   . VAL   B 1 228 ? -20.84460 -9.65421  53.09338 1.000 11.10801 ? 228 VAL   B O   1 
ATOM   3702 C  CB  . VAL   B 1 228 ? -17.51324 -10.11929 52.59344 1.000 15.09877 ? 228 VAL   B CB  1 
ATOM   3703 C  CG1 . VAL   B 1 228 ? -18.16217 -11.47682 52.41719 1.000 12.35955 ? 228 VAL   B CG1 1 
ATOM   3704 C  CG2 . VAL   B 1 228 ? -16.49629 -9.86506  51.49806 1.000 12.93560 ? 228 VAL   B CG2 1 
ATOM   3705 N  N   . LEU   B 1 229 ? -19.47660 -9.30589  54.84402 1.000 9.81877  ? 229 LEU   B N   1 
ATOM   3706 C  CA  . LEU   B 1 229 ? -20.51809 -9.62646  55.81418 1.000 13.76031 ? 229 LEU   B CA  1 
ATOM   3707 C  C   . LEU   B 1 229 ? -21.67119 -8.63565  55.73055 1.000 13.39352 ? 229 LEU   B C   1 
ATOM   3708 O  O   . LEU   B 1 229 ? -22.84399 -9.02756  55.71737 1.000 12.57770 ? 229 LEU   B O   1 
ATOM   3709 C  CB  . LEU   B 1 229 ? -19.92837 -9.63991  57.22410 1.000 15.27547 ? 229 LEU   B CB  1 
ATOM   3710 C  CG  . LEU   B 1 229 ? -19.06985 -10.84538 57.59824 1.000 17.55649 ? 229 LEU   B CG  1 
ATOM   3711 C  CD1 . LEU   B 1 229 ? -18.30490 -10.58047 58.88491 1.000 17.14399 ? 229 LEU   B CD1 1 
ATOM   3712 C  CD2 . LEU   B 1 229 ? -19.94556 -12.07076 57.73564 1.000 16.29465 ? 229 LEU   B CD2 1 
ATOM   3713 N  N   . GLU   B 1 230 ? -21.35023 -7.34142  55.66163 1.000 11.29209 ? 230 GLU   B N   1 
ATOM   3714 C  CA  . GLU   B 1 230 ? -22.37822 -6.30896  55.74422 1.000 13.34779 ? 230 GLU   B CA  1 
ATOM   3715 C  C   . GLU   B 1 230 ? -23.32099 -6.36112  54.54716 1.000 11.82938 ? 230 GLU   B C   1 
ATOM   3716 O  O   . GLU   B 1 230 ? -24.53425 -6.17248  54.69696 1.000 12.83490 ? 230 GLU   B O   1 
ATOM   3717 C  CB  . GLU   B 1 230 ? -21.72277 -4.93223  55.86848 1.000 13.68453 ? 230 GLU   B CB  1 
ATOM   3718 C  CG  . GLU   B 1 230 ? -21.00642 -4.69425  57.20101 1.000 12.15488 ? 230 GLU   B CG  1 
ATOM   3719 C  CD  . GLU   B 1 230 ? -19.68536 -5.44037  57.31869 1.000 15.46716 ? 230 GLU   B CD  1 
ATOM   3720 O  OE1 . GLU   B 1 230 ? -19.10427 -5.80329  56.27380 1.000 13.43932 ? 230 GLU   B OE1 1 
ATOM   3721 O  OE2 . GLU   B 1 230 ? -19.22869 -5.66732  58.45998 1.000 14.71586 ? 230 GLU   B OE2 1 
ATOM   3722 N  N   . ASN   B 1 231 ? -22.78491 -6.61515  53.35026 1.000 10.27579 ? 231 ASN   B N   1 
ATOM   3723 C  CA  . ASN   B 1 231 ? -23.64726 -6.83086  52.19223 1.000 13.31055 ? 231 ASN   B CA  1 
ATOM   3724 C  C   . ASN   B 1 231 ? -24.54355 -8.04460  52.39698 1.000 13.10689 ? 231 ASN   B C   1 
ATOM   3725 O  O   . ASN   B 1 231 ? -25.72381 -8.02622  52.02737 1.000 12.82680 ? 231 ASN   B O   1 
ATOM   3726 C  CB  . ASN   B 1 231 ? -22.80601 -7.00563  50.92797 1.000 13.72409 ? 231 ASN   B CB  1 
ATOM   3727 C  CG  . ASN   B 1 231 ? -22.37180 -5.68768  50.32359 1.000 18.03281 ? 231 ASN   B CG  1 
ATOM   3728 O  OD1 . ASN   B 1 231 ? -23.18682 -4.94656  49.77471 1.000 16.79583 ? 231 ASN   B OD1 1 
ATOM   3729 N  ND2 . ASN   B 1 231 ? -21.07842 -5.39690  50.40303 1.000 15.40637 ? 231 ASN   B ND2 1 
ATOM   3730 N  N   . HIS   B 1 232 ? -23.99720 -9.10922  52.98779 1.000 12.76472 ? 232 HIS   B N   1 
ATOM   3731 C  CA  . HIS   B 1 232 ? -24.77369 -10.32372 53.21143 1.000 12.09979 ? 232 HIS   B CA  1 
ATOM   3732 C  C   . HIS   B 1 232 ? -25.88336 -10.08807 54.22887 1.000 14.03678 ? 232 HIS   B C   1 
ATOM   3733 O  O   . HIS   B 1 232 ? -27.02368 -10.52280 54.02642 1.000 15.41653 ? 232 HIS   B O   1 
ATOM   3734 C  CB  . HIS   B 1 232 ? -23.85004 -11.45318 53.66763 1.000 14.48286 ? 232 HIS   B CB  1 
ATOM   3735 C  CG  . HIS   B 1 232 ? -24.54974 -12.75834 53.88365 1.000 14.93273 ? 232 HIS   B CG  1 
ATOM   3736 N  ND1 . HIS   B 1 232 ? -25.17965 -13.44288 52.86673 1.000 12.77596 ? 232 HIS   B ND1 1 
ATOM   3737 C  CD2 . HIS   B 1 232 ? -24.71539 -13.50655 54.99976 1.000 12.49391 ? 232 HIS   B CD2 1 
ATOM   3738 C  CE1 . HIS   B 1 232 ? -25.70363 -14.55634 53.34699 1.000 13.94225 ? 232 HIS   B CE1 1 
ATOM   3739 N  NE2 . HIS   B 1 232 ? -25.43665 -14.61854 54.63903 1.000 13.43147 ? 232 HIS   B NE2 1 
ATOM   3740 N  N   . HIS   B 1 233 ? -25.56360 -9.40786  55.33570 1.000 15.16738 ? 233 HIS   B N   1 
ATOM   3741 C  CA  . HIS   B 1 233 ? -26.58190 -9.05575  56.32250 1.000 13.17182 ? 233 HIS   B CA  1 
ATOM   3742 C  C   . HIS   B 1 233 ? -27.74923 -8.33204  55.66464 1.000 14.53736 ? 233 HIS   B C   1 
ATOM   3743 O  O   . HIS   B 1 233 ? -28.91796 -8.65102  55.91100 1.000 13.91428 ? 233 HIS   B O   1 
ATOM   3744 C  CB  . HIS   B 1 233 ? -25.97859 -8.17702  57.42195 1.000 12.49916 ? 233 HIS   B CB  1 
ATOM   3745 C  CG  . HIS   B 1 233 ? -24.77758 -8.76693  58.09333 1.000 14.59211 ? 233 HIS   B CG  1 
ATOM   3746 N  ND1 . HIS   B 1 233 ? -24.69191 -10.09795 58.44025 1.000 12.45990 ? 233 HIS   B ND1 1 
ATOM   3747 C  CD2 . HIS   B 1 233 ? -23.61460 -8.19899  58.49201 1.000 12.20372 ? 233 HIS   B CD2 1 
ATOM   3748 C  CE1 . HIS   B 1 233 ? -23.52656 -10.32540 59.02000 1.000 11.91650 ? 233 HIS   B CE1 1 
ATOM   3749 N  NE2 . HIS   B 1 233 ? -22.85383 -9.18962  59.06318 1.000 12.47468 ? 233 HIS   B NE2 1 
ATOM   3750 N  N   . LEU   B 1 234 ? -27.44213 -7.34670  54.81952 1.000 12.69294 ? 234 LEU   B N   1 
ATOM   3751 C  CA  . LEU   B 1 234 ? -28.48636 -6.60604  54.12073 1.000 17.55382 ? 234 LEU   B CA  1 
ATOM   3752 C  C   . LEU   B 1 234 ? -29.29408 -7.52099  53.21077 1.000 15.79434 ? 234 LEU   B C   1 
ATOM   3753 O  O   . LEU   B 1 234 ? -30.53016 -7.51683  53.24663 1.000 16.88108 ? 234 LEU   B O   1 
ATOM   3754 C  CB  . LEU   B 1 234 ? -27.86291 -5.46502  53.31812 1.000 11.67398 ? 234 LEU   B CB  1 
ATOM   3755 C  CG  . LEU   B 1 234 ? -27.43365 -4.22930  54.10451 1.000 11.94235 ? 234 LEU   B CG  1 
ATOM   3756 C  CD1 . LEU   B 1 234 ? -26.47262 -3.38278  53.28634 1.000 10.71504 ? 234 LEU   B CD1 1 
ATOM   3757 C  CD2 . LEU   B 1 234 ? -28.66050 -3.42335  54.49291 1.000 13.16591 ? 234 LEU   B CD2 1 
ATOM   3758 N  N   . ALA   B 1 235 ? -28.60539 -8.31568  52.38669 1.000 13.91695 ? 235 ALA   B N   1 
ATOM   3759 C  CA  . ALA   B 1 235 ? -29.28666 -9.20099  51.44748 1.000 15.73166 ? 235 ALA   B CA  1 
ATOM   3760 C  C   . ALA   B 1 235 ? -30.26605 -10.12063 52.16591 1.000 16.01498 ? 235 ALA   B C   1 
ATOM   3761 O  O   . ALA   B 1 235 ? -31.41539 -10.27504 51.74131 1.000 13.12834 ? 235 ALA   B O   1 
ATOM   3762 C  CB  . ALA   B 1 235 ? -28.26020 -10.01531 50.65777 1.000 12.12393 ? 235 ALA   B CB  1 
ATOM   3763 N  N   . VAL   B 1 236 ? -29.83095 -10.72557 53.27308 1.000 15.72653 ? 236 VAL   B N   1 
ATOM   3764 C  CA  . VAL   B 1 236 ? -30.71387 -11.60574 54.03183 1.000 14.77737 ? 236 VAL   B CA  1 
ATOM   3765 C  C   . VAL   B 1 236 ? -31.84610 -10.81139 54.67310 1.000 21.22968 ? 236 VAL   B C   1 
ATOM   3766 O  O   . VAL   B 1 236 ? -33.01218 -11.22216 54.62650 1.000 17.15389 ? 236 VAL   B O   1 
ATOM   3767 C  CB  . VAL   B 1 236 ? -29.90907 -12.39141 55.08258 1.000 16.66456 ? 236 VAL   B CB  1 
ATOM   3768 C  CG1 . VAL   B 1 236 ? -30.84383 -13.19849 55.96856 1.000 17.82262 ? 236 VAL   B CG1 1 
ATOM   3769 C  CG2 . VAL   B 1 236 ? -28.89192 -13.29669 54.40540 1.000 14.04521 ? 236 VAL   B CG2 1 
ATOM   3770 N  N   . GLY   B 1 237 ? -31.52507 -9.66240  55.27395 1.000 17.23445 ? 237 GLY   B N   1 
ATOM   3771 C  CA  . GLY   B 1 237 ? -32.54108 -8.89253  55.97644 1.000 17.22861 ? 237 GLY   B CA  1 
ATOM   3772 C  C   . GLY   B 1 237 ? -33.68311 -8.45527  55.07849 1.000 20.67397 ? 237 GLY   B C   1 
ATOM   3773 O  O   . GLY   B 1 237 ? -34.85133 -8.51185  55.47222 1.000 20.67122 ? 237 GLY   B O   1 
ATOM   3774 N  N   . PHE   B 1 238 ? -33.36367 -8.01052  53.86067 1.000 19.46869 ? 238 PHE   B N   1 
ATOM   3775 C  CA  . PHE   B 1 238 ? -34.40964 -7.65262  52.90817 1.000 21.78697 ? 238 PHE   B CA  1 
ATOM   3776 C  C   . PHE   B 1 238 ? -35.08152 -8.88935  52.32385 1.000 18.65346 ? 238 PHE   B C   1 
ATOM   3777 O  O   . PHE   B 1 238 ? -36.29595 -8.88693  52.09724 1.000 21.59981 ? 238 PHE   B O   1 
ATOM   3778 C  CB  . PHE   B 1 238 ? -33.83653 -6.78914  51.78255 1.000 17.50798 ? 238 PHE   B CB  1 
ATOM   3779 C  CG  . PHE   B 1 238 ? -33.42082 -5.41374  52.21798 1.000 18.12476 ? 238 PHE   B CG  1 
ATOM   3780 C  CD1 . PHE   B 1 238 ? -34.36769 -4.47245  52.58754 1.000 18.11785 ? 238 PHE   B CD1 1 
ATOM   3781 C  CD2 . PHE   B 1 238 ? -32.08387 -5.05523  52.23625 1.000 21.61066 ? 238 PHE   B CD2 1 
ATOM   3782 C  CE1 . PHE   B 1 238 ? -33.98612 -3.20429  52.98324 1.000 17.86740 ? 238 PHE   B CE1 1 
ATOM   3783 C  CE2 . PHE   B 1 238 ? -31.69579 -3.79003  52.62883 1.000 17.37471 ? 238 PHE   B CE2 1 
ATOM   3784 C  CZ  . PHE   B 1 238 ? -32.64830 -2.86252  53.00260 1.000 19.64102 ? 238 PHE   B CZ  1 
ATOM   3785 N  N   . LYS   B 1 239 ? -34.30621 -9.94872  52.07397 1.000 23.29402 ? 239 LYS   B N   1 
ATOM   3786 C  CA  . LYS   B 1 239 ? -34.85942 -11.16413 51.48093 1.000 22.80739 ? 239 LYS   B CA  1 
ATOM   3787 C  C   . LYS   B 1 239 ? -35.97895 -11.74396 52.33577 1.000 23.73535 ? 239 LYS   B C   1 
ATOM   3788 O  O   . LYS   B 1 239 ? -37.00026 -12.20115 51.80876 1.000 25.17887 ? 239 LYS   B O   1 
ATOM   3789 C  CB  . LYS   B 1 239 ? -33.75028 -12.19890 51.28902 1.000 24.55988 ? 239 LYS   B CB  1 
ATOM   3790 C  CG  . LYS   B 1 239 ? -34.21364 -13.54655 50.77054 1.000 24.09257 ? 239 LYS   B CG  1 
ATOM   3791 C  CD  . LYS   B 1 239 ? -34.67912 -13.44954 49.33213 1.000 33.13661 ? 239 LYS   B CD  1 
ATOM   3792 C  CE  . LYS   B 1 239 ? -34.92434 -14.82755 48.74452 1.000 34.56501 ? 239 LYS   B CE  1 
ATOM   3793 N  NZ  . LYS   B 1 239 ? -35.20748 -14.76030 47.28524 1.000 32.07227 ? 239 LYS   B NZ  1 
ATOM   3794 N  N   . LEU   B 1 240 ? -35.80595 -11.73047 53.65953 1.000 21.23755 ? 240 LEU   B N   1 
ATOM   3795 C  CA  . LEU   B 1 240 ? -36.79789 -12.33255 54.54376 1.000 22.02917 ? 240 LEU   B CA  1 
ATOM   3796 C  C   . LEU   B 1 240 ? -38.12690 -11.59134 54.49513 1.000 24.20166 ? 240 LEU   B C   1 
ATOM   3797 O  O   . LEU   B 1 240 ? -39.16980 -12.17227 54.81694 1.000 26.41092 ? 240 LEU   B O   1 
ATOM   3798 C  CB  . LEU   B 1 240 ? -36.26147 -12.37627 55.97357 1.000 19.60840 ? 240 LEU   B CB  1 
ATOM   3799 C  CG  . LEU   B 1 240 ? -35.05569 -13.29812 56.16239 1.000 23.37854 ? 240 LEU   B CG  1 
ATOM   3800 C  CD1 . LEU   B 1 240 ? -34.52231 -13.22465 57.58394 1.000 18.71046 ? 240 LEU   B CD1 1 
ATOM   3801 C  CD2 . LEU   B 1 240 ? -35.42833 -14.72532 55.79667 1.000 24.85186 ? 240 LEU   B CD2 1 
ATOM   3802 N  N   . LEU   B 1 241 ? -38.11295 -10.31436 54.09935 1.000 25.01970 ? 241 LEU   B N   1 
ATOM   3803 C  CA  . LEU   B 1 241 ? -39.36154 -9.57587  53.93304 1.000 26.94594 ? 241 LEU   B CA  1 
ATOM   3804 C  C   . LEU   B 1 241 ? -40.28956 -10.26055 52.93918 1.000 25.91126 ? 241 LEU   B C   1 
ATOM   3805 O  O   . LEU   B 1 241 ? -41.51532 -10.14685 53.05284 1.000 31.79602 ? 241 LEU   B O   1 
ATOM   3806 C  CB  . LEU   B 1 241 ? -39.07655 -8.14525  53.47243 1.000 29.44299 ? 241 LEU   B CB  1 
ATOM   3807 C  CG  . LEU   B 1 241 ? -38.35425 -7.18815  54.41981 1.000 29.07533 ? 241 LEU   B CG  1 
ATOM   3808 C  CD1 . LEU   B 1 241 ? -38.00177 -5.90186  53.68973 1.000 26.61313 ? 241 LEU   B CD1 1 
ATOM   3809 C  CD2 . LEU   B 1 241 ? -39.21589 -6.89407  55.63365 1.000 23.61756 ? 241 LEU   B CD2 1 
ATOM   3810 N  N   . GLN   B 1 242 ? -39.72902 -10.97546 51.96669 1.000 25.09959 ? 242 GLN   B N   1 
ATOM   3811 C  CA  . GLN   B 1 242 ? -40.51613 -11.61581 50.92305 1.000 24.42563 ? 242 GLN   B CA  1 
ATOM   3812 C  C   . GLN   B 1 242 ? -41.10997 -12.94958 51.35503 1.000 36.22768 ? 242 GLN   B C   1 
ATOM   3813 O  O   . GLN   B 1 242 ? -41.85720 -13.55514 50.57922 1.000 36.38098 ? 242 GLN   B O   1 
ATOM   3814 C  CB  . GLN   B 1 242 ? -39.65719 -11.79731 49.67029 1.000 27.43529 ? 242 GLN   B CB  1 
ATOM   3815 C  CG  . GLN   B 1 242 ? -39.37273 -10.48512 48.95765 1.000 32.06945 ? 242 GLN   B CG  1 
ATOM   3816 C  CD  . GLN   B 1 242 ? -38.30455 -10.60938 47.89464 1.000 37.33342 ? 242 GLN   B CD  1 
ATOM   3817 O  OE1 . GLN   B 1 242 ? -38.00243 -11.70623 47.42581 1.000 42.31345 ? 242 GLN   B OE1 1 
ATOM   3818 N  NE2 . GLN   B 1 242 ? -37.72374 -9.47944  47.50688 1.000 33.34697 ? 242 GLN   B NE2 1 
ATOM   3819 N  N   . GLU   B 1 243 ? -40.80594 -13.42009 52.56158 1.000 33.29945 ? 243 GLU   B N   1 
ATOM   3820 C  CA  . GLU   B 1 243 ? -41.47665 -14.60228 53.07205 1.000 35.32940 ? 243 GLU   B CA  1 
ATOM   3821 C  C   . GLU   B 1 243 ? -42.93194 -14.27378 53.40678 1.000 37.31734 ? 243 GLU   B C   1 
ATOM   3822 O  O   . GLU   B 1 243 ? -43.33637 -13.10962 53.48513 1.000 38.78550 ? 243 GLU   B O   1 
ATOM   3823 C  CB  . GLU   B 1 243 ? -40.75019 -15.15247 54.29914 1.000 33.51071 ? 243 GLU   B CB  1 
ATOM   3824 C  CG  . GLU   B 1 243 ? -39.33533 -15.64515 54.02171 1.000 32.85234 ? 243 GLU   B CG  1 
ATOM   3825 C  CD  . GLU   B 1 243 ? -39.29822 -16.88035 53.13596 1.000 39.20130 ? 243 GLU   B CD  1 
ATOM   3826 O  OE1 . GLU   B 1 243 ? -40.20766 -17.72824 53.25200 1.000 46.33318 ? 243 GLU   B OE1 1 
ATOM   3827 O  OE2 . GLU   B 1 243 ? -38.35708 -17.00388 52.32310 1.000 38.06447 ? 243 GLU   B OE2 1 
ATOM   3828 N  N   . GLU   B 1 244 ? -43.71743 -15.33141 53.60986 1.000 41.17890 ? 244 GLU   B N   1 
ATOM   3829 C  CA  . GLU   B 1 244 ? -45.15641 -15.20230 53.81637 1.000 40.10464 ? 244 GLU   B CA  1 
ATOM   3830 C  C   . GLU   B 1 244 ? -45.45927 -14.32092 55.02426 1.000 42.84105 ? 244 GLU   B C   1 
ATOM   3831 O  O   . GLU   B 1 244 ? -44.93097 -14.54736 56.11693 1.000 43.20555 ? 244 GLU   B O   1 
ATOM   3832 C  CB  . GLU   B 1 244 ? -45.76445 -16.59696 53.99809 1.000 48.08437 ? 244 GLU   B CB  1 
ATOM   3833 C  CG  . GLU   B 1 244 ? -47.27010 -16.70797 53.85749 1.000 55.23903 ? 244 GLU   B CG  1 
ATOM   3834 C  CD  . GLU   B 1 244 ? -47.99561 -16.55465 55.16991 1.000 62.14562 ? 244 GLU   B CD  1 
ATOM   3835 O  OE1 . GLU   B 1 244 ? -48.60531 -15.50518 55.38982 1.000 64.04949 ? 244 GLU   B OE1 1 
ATOM   3836 O  OE2 . GLU   B 1 244 ? -47.97463 -17.49174 55.97817 1.000 65.13227 ? 244 GLU   B OE2 1 
ATOM   3837 N  N   . ASN   B 1 245 ? -46.30296 -13.30284 54.81377 1.000 42.22468 ? 245 ASN   B N   1 
ATOM   3838 C  CA  . ASN   B 1 245 ? -46.76359 -12.39871 55.87548 1.000 43.02517 ? 245 ASN   B CA  1 
ATOM   3839 C  C   . ASN   B 1 245 ? -45.60808 -11.71167 56.59835 1.000 41.00555 ? 245 ASN   B C   1 
ATOM   3840 O  O   . ASN   B 1 245 ? -45.71308 -11.38822 57.78296 1.000 41.13920 ? 245 ASN   B O   1 
ATOM   3841 C  CB  . ASN   B 1 245 ? -47.65211 -13.13209 56.88603 1.000 44.71221 ? 245 ASN   B CB  1 
ATOM   3842 C  CG  . ASN   B 1 245 ? -48.56887 -12.21776 57.64081 1.000 46.11048 ? 245 ASN   B CG  1 
ATOM   3843 O  OD1 . ASN   B 1 245 ? -49.19845 -12.61105 58.56923 1.000 57.48857 ? 245 ASN   B OD1 1 
ATOM   3844 N  ND2 . ASN   B 1 245 ? -48.65633 -11.00259 57.24915 1.000 47.97293 ? 245 ASN   B ND2 1 
ATOM   3845 N  N   . CYS   B 1 246 ? -44.49686 -11.47880 55.90228 1.000 40.78058 ? 246 CYS   B N   1 
ATOM   3846 C  CA  . CYS   B 1 246 ? -43.32307 -10.88485 56.52406 1.000 33.03515 ? 246 CYS   B CA  1 
ATOM   3847 C  C   . CYS   B 1 246 ? -43.01669 -9.47547  56.03989 1.000 34.52547 ? 246 CYS   B C   1 
ATOM   3848 O  O   . CYS   B 1 246 ? -42.12249 -8.83179  56.59967 1.000 31.38408 ? 246 CYS   B O   1 
ATOM   3849 C  CB  . CYS   B 1 246 ? -42.09012 -11.77218 56.29626 1.000 28.50510 ? 246 CYS   B CB  1 
ATOM   3850 S  SG  . CYS   B 1 246 ? -42.07232 -13.29648 57.27170 1.000 33.99296 ? 246 CYS   B SG  1 
ATOM   3851 N  N   . ASP   B 1 247 ? -43.72883 -8.97385  55.03061 1.000 33.21207 ? 247 ASP   B N   1 
ATOM   3852 C  CA  . ASP   B 1 247 ? -43.46455 -7.63964  54.49216 1.000 30.31455 ? 247 ASP   B CA  1 
ATOM   3853 C  C   . ASP   B 1 247 ? -44.09899 -6.60352  55.41661 1.000 34.95632 ? 247 ASP   B C   1 
ATOM   3854 O  O   . ASP   B 1 247 ? -45.21210 -6.11674  55.20061 1.000 33.90370 ? 247 ASP   B O   1 
ATOM   3855 C  CB  . ASP   B 1 247 ? -43.98792 -7.51700  53.06686 1.000 34.01884 ? 247 ASP   B CB  1 
ATOM   3856 C  CG  . ASP   B 1 247 ? -43.56238 -6.22011  52.39634 1.000 36.89181 ? 247 ASP   B CG  1 
ATOM   3857 O  OD1 . ASP   B 1 247 ? -42.93739 -5.36932  53.06473 1.000 32.71258 ? 247 ASP   B OD1 1 
ATOM   3858 O  OD2 . ASP   B 1 247 ? -43.85712 -6.04927  51.19474 1.000 42.94988 ? 247 ASP   B OD2 1 
ATOM   3859 N  N   . ILE   B 1 248 ? -43.35124 -6.24469  56.46327 1.000 29.37599 ? 248 ILE   B N   1 
ATOM   3860 C  CA  . ILE   B 1 248 ? -43.79082 -5.20985  57.39208 1.000 32.50755 ? 248 ILE   B CA  1 
ATOM   3861 C  C   . ILE   B 1 248 ? -43.83449 -3.82854  56.75847 1.000 32.18698 ? 248 ILE   B C   1 
ATOM   3862 O  O   . ILE   B 1 248 ? -44.29938 -2.87871  57.39892 1.000 28.43693 ? 248 ILE   B O   1 
ATOM   3863 C  CB  . ILE   B 1 248 ? -42.87225 -5.18195  58.62976 1.000 32.83253 ? 248 ILE   B CB  1 
ATOM   3864 C  CG1 . ILE   B 1 248 ? -41.47651 -4.69204  58.24168 1.000 28.04421 ? 248 ILE   B CG1 1 
ATOM   3865 C  CG2 . ILE   B 1 248 ? -42.78548 -6.56283  59.25263 1.000 31.98063 ? 248 ILE   B CG2 1 
ATOM   3866 C  CD1 . ILE   B 1 248 ? -40.53190 -4.54154  59.41191 1.000 28.40501 ? 248 ILE   B CD1 1 
ATOM   3867 N  N   . PHE   B 1 249 ? -43.36006 -3.69166  55.52017 1.000 31.75487 ? 249 PHE   B N   1 
ATOM   3868 C  CA  . PHE   B 1 249 ? -43.34890 -2.42366  54.80222 1.000 32.19118 ? 249 PHE   B CA  1 
ATOM   3869 C  C   . PHE   B 1 249 ? -44.42348 -2.35637  53.72448 1.000 34.41466 ? 249 PHE   B C   1 
ATOM   3870 O  O   . PHE   B 1 249 ? -44.38796 -1.45222  52.88225 1.000 32.67062 ? 249 PHE   B O   1 
ATOM   3871 C  CB  . PHE   B 1 249 ? -41.97174 -2.19038  54.17801 1.000 31.20317 ? 249 PHE   B CB  1 
ATOM   3872 C  CG  . PHE   B 1 249 ? -40.85098 -2.18027  55.17450 1.000 33.14193 ? 249 PHE   B CG  1 
ATOM   3873 C  CD1 . PHE   B 1 249 ? -40.93933 -1.41413  56.32376 1.000 33.17857 ? 249 PHE   B CD1 1 
ATOM   3874 C  CD2 . PHE   B 1 249 ? -39.71489 -2.94711  54.97012 1.000 30.40864 ? 249 PHE   B CD2 1 
ATOM   3875 C  CE1 . PHE   B 1 249 ? -39.91387 -1.40607  57.24927 1.000 32.08710 ? 249 PHE   B CE1 1 
ATOM   3876 C  CE2 . PHE   B 1 249 ? -38.68312 -2.94160  55.89113 1.000 27.91031 ? 249 PHE   B CE2 1 
ATOM   3877 C  CZ  . PHE   B 1 249 ? -38.78267 -2.16885  57.03171 1.000 27.55553 ? 249 PHE   B CZ  1 
ATOM   3878 N  N   . GLN   B 1 250 ? -45.38526 -3.28404  53.74516 1.000 30.03599 ? 250 GLN   B N   1 
ATOM   3879 C  CA  . GLN   B 1 250 ? -46.33152 -3.43429  52.64265 1.000 36.99640 ? 250 GLN   B CA  1 
ATOM   3880 C  C   . GLN   B 1 250 ? -47.14190 -2.16952  52.39183 1.000 34.10821 ? 250 GLN   B C   1 
ATOM   3881 O  O   . GLN   B 1 250 ? -47.59615 -1.94073  51.26506 1.000 33.70364 ? 250 GLN   B O   1 
ATOM   3882 C  CB  . GLN   B 1 250 ? -47.27107 -4.60356  52.93080 1.000 30.12177 ? 250 GLN   B CB  1 
ATOM   3883 C  CG  . GLN   B 1 250 ? -48.00500 -4.46523  54.25563 1.000 36.41457 ? 250 GLN   B CG  1 
ATOM   3884 C  CD  . GLN   B 1 250 ? -48.81106 -5.69483  54.61426 1.000 42.34610 ? 250 GLN   B CD  1 
ATOM   3885 O  OE1 . GLN   B 1 250 ? -50.02886 -5.62570  54.77915 1.000 42.54786 ? 250 GLN   B OE1 1 
ATOM   3886 N  NE2 . GLN   B 1 250 ? -48.13378 -6.82944  54.74390 1.000 40.62634 ? 250 GLN   B NE2 1 
ATOM   3887 N  N   . ASN   B 1 251 ? -47.34100 -1.34244  53.41552 1.000 32.71841 ? 251 ASN   B N   1 
ATOM   3888 C  CA  . ASN   B 1 251 ? -48.19121 -0.16752  53.29778 1.000 39.28089 ? 251 ASN   B CA  1 
ATOM   3889 C  C   . ASN   B 1 251 ? -47.41003 1.13377   53.20757 1.000 38.28972 ? 251 ASN   B C   1 
ATOM   3890 O  O   . ASN   B 1 251 ? -48.02309 2.20219   53.10654 1.000 36.67216 ? 251 ASN   B O   1 
ATOM   3891 C  CB  . ASN   B 1 251 ? -49.17636 -0.11558  54.46828 1.000 37.57700 ? 251 ASN   B CB  1 
ATOM   3892 C  CG  . ASN   B 1 251 ? -50.16193 -1.26568  54.43903 1.000 40.08815 ? 251 ASN   B CG  1 
ATOM   3893 O  OD1 . ASN   B 1 251 ? -50.62953 -1.66792  53.37257 1.000 41.72266 ? 251 ASN   B OD1 1 
ATOM   3894 N  ND2 . ASN   B 1 251 ? -50.47362 -1.81032  55.60780 1.000 44.43822 ? 251 ASN   B ND2 1 
ATOM   3895 N  N   . LEU   B 1 252 ? -46.08209 1.07886   53.24858 1.000 35.39605 ? 252 LEU   B N   1 
ATOM   3896 C  CA  . LEU   B 1 252 ? -45.29409 2.23124   52.84215 1.000 38.42100 ? 252 LEU   B CA  1 
ATOM   3897 C  C   . LEU   B 1 252 ? -45.52626 2.49721   51.36211 1.000 36.55488 ? 252 LEU   B C   1 
ATOM   3898 O  O   . LEU   B 1 252 ? -45.68352 1.56649   50.56752 1.000 35.48603 ? 252 LEU   B O   1 
ATOM   3899 C  CB  . LEU   B 1 252 ? -43.80474 1.99333   53.10186 1.000 36.53369 ? 252 LEU   B CB  1 
ATOM   3900 C  CG  . LEU   B 1 252 ? -43.22100 2.34155   54.47248 1.000 35.29304 ? 252 LEU   B CG  1 
ATOM   3901 C  CD1 . LEU   B 1 252 ? -43.80920 1.46332   55.56406 1.000 33.13092 ? 252 LEU   B CD1 1 
ATOM   3902 C  CD2 . LEU   B 1 252 ? -41.70269 2.22468   54.44369 1.000 31.06300 ? 252 LEU   B CD2 1 
ATOM   3903 N  N   . THR   B 1 253 ? -45.55856 3.77278   50.98887 1.000 33.63369 ? 253 THR   B N   1 
ATOM   3904 C  CA  . THR   B 1 253 ? -45.62642 4.10071   49.57691 1.000 31.84270 ? 253 THR   B CA  1 
ATOM   3905 C  C   . THR   B 1 253 ? -44.37827 3.58058   48.86399 1.000 39.55499 ? 253 THR   B C   1 
ATOM   3906 O  O   . THR   B 1 253 ? -43.39398 3.17503   49.48743 1.000 30.14372 ? 253 THR   B O   1 
ATOM   3907 C  CB  . THR   B 1 253 ? -45.75328 5.60809   49.37180 1.000 31.96564 ? 253 THR   B CB  1 
ATOM   3908 O  OG1 . THR   B 1 253 ? -44.47882 6.22701   49.58116 1.000 39.61331 ? 253 THR   B OG1 1 
ATOM   3909 C  CG2 . THR   B 1 253 ? -46.76604 6.20203   50.33769 1.000 32.12472 ? 253 THR   B CG2 1 
ATOM   3910 N  N   . LYS   B 1 254 ? -44.42576 3.59625   47.53084 1.000 39.22331 ? 254 LYS   B N   1 
ATOM   3911 C  CA  . LYS   B 1 254 ? -43.30034 3.08365   46.75663 1.000 40.49792 ? 254 LYS   B CA  1 
ATOM   3912 C  C   . LYS   B 1 254 ? -42.05086 3.92921   46.97901 1.000 39.23312 ? 254 LYS   B C   1 
ATOM   3913 O  O   . LYS   B 1 254 ? -40.94138 3.39410   47.09420 1.000 34.56303 ? 254 LYS   B O   1 
ATOM   3914 C  CB  . LYS   B 1 254 ? -43.66942 3.02878   45.27383 1.000 43.75488 ? 254 LYS   B CB  1 
ATOM   3915 C  CG  . LYS   B 1 254 ? -42.53407 2.60393   44.35998 1.000 45.31378 ? 254 LYS   B CG  1 
ATOM   3916 C  CD  . LYS   B 1 254 ? -42.57244 3.36325   43.05949 1.000 54.04181 ? 254 LYS   B CD  1 
ATOM   3917 C  CE  . LYS   B 1 254 ? -41.91687 4.70014   43.20087 1.000 59.34133 ? 254 LYS   B CE  1 
ATOM   3918 N  NZ  . LYS   B 1 254 ? -40.59452 4.61369   43.82256 1.000 64.21982 ? 254 LYS   B NZ  1 
ATOM   3919 N  N   . LYS   B 1 255 ? -42.21508 5.25167   47.06566 1.000 35.29679 ? 255 LYS   B N   1 
ATOM   3920 C  CA  . LYS   B 1 255 ? -41.06801 6.12447   47.29690 1.000 35.53289 ? 255 LYS   B CA  1 
ATOM   3921 C  C   . LYS   B 1 255 ? -40.56607 6.01271   48.72940 1.000 32.43205 ? 255 LYS   B C   1 
ATOM   3922 O  O   . LYS   B 1 255 ? -39.35906 6.10694   48.97567 1.000 28.10218 ? 255 LYS   B O   1 
ATOM   3923 C  CB  . LYS   B 1 255 ? -41.41646 7.57720   46.96085 1.000 31.63818 ? 255 LYS   B CB  1 
ATOM   3924 C  CG  . LYS   B 1 255 ? -40.97036 8.00307   45.55800 1.000 42.09338 ? 255 LYS   B CG  1 
ATOM   3925 C  CD  . LYS   B 1 255 ? -39.61211 8.71462   45.61802 1.000 47.30820 ? 255 LYS   B CD  1 
ATOM   3926 C  CE  . LYS   B 1 255 ? -39.10319 9.08385   44.23651 1.000 50.08928 ? 255 LYS   B CE  1 
ATOM   3927 N  NZ  . LYS   B 1 255 ? -37.62894 8.99042   44.11799 1.000 44.73374 ? 255 LYS   B NZ  1 
ATOM   3928 N  N   . GLN   B 1 256 ? -41.47582 5.83590   49.68838 1.000 32.75980 ? 256 GLN   B N   1 
ATOM   3929 C  CA  . GLN   B 1 256 ? -41.05816 5.58314   51.06393 1.000 32.49593 ? 256 GLN   B CA  1 
ATOM   3930 C  C   . GLN   B 1 256 ? -40.22951 4.30718   51.15535 1.000 30.79490 ? 256 GLN   B C   1 
ATOM   3931 O  O   . GLN   B 1 256 ? -39.16702 4.28629   51.78745 1.000 26.97662 ? 256 GLN   B O   1 
ATOM   3932 C  CB  . GLN   B 1 256 ? -42.27957 5.49747   51.98302 1.000 30.96635 ? 256 GLN   B CB  1 
ATOM   3933 C  CG  . GLN   B 1 256 ? -42.93536 6.83217   52.30048 1.000 32.56859 ? 256 GLN   B CG  1 
ATOM   3934 C  CD  . GLN   B 1 256 ? -44.14749 6.67819   53.20077 1.000 38.15725 ? 256 GLN   B CD  1 
ATOM   3935 O  OE1 . GLN   B 1 256 ? -44.98210 5.79770   52.99149 1.000 35.71275 ? 256 GLN   B OE1 1 
ATOM   3936 N  NE2 . GLN   B 1 256 ? -44.24901 7.53483   54.21012 1.000 45.96029 ? 256 GLN   B NE2 1 
ATOM   3937 N  N   . ARG   B 1 257 ? -40.71193 3.22718   50.53451 1.000 31.70777 ? 257 ARG   B N   1 
ATOM   3938 C  CA  . ARG   B 1 257 ? -39.95411 1.97912   50.48838 1.000 31.25185 ? 257 ARG   B CA  1 
ATOM   3939 C  C   . ARG   B 1 257 ? -38.57173 2.19992   49.89122 1.000 28.05200 ? 257 ARG   B C   1 
ATOM   3940 O  O   . ARG   B 1 257 ? -37.55964 1.73979   50.43344 1.000 28.11532 ? 257 ARG   B O   1 
ATOM   3941 C  CB  . ARG   B 1 257 ? -40.71612 0.94262   49.66427 1.000 29.79942 ? 257 ARG   B CB  1 
ATOM   3942 C  CG  . ARG   B 1 257 ? -41.97837 0.40548   50.30179 1.000 35.55580 ? 257 ARG   B CG  1 
ATOM   3943 C  CD  . ARG   B 1 257 ? -42.79575 -0.36458  49.27246 1.000 37.18622 ? 257 ARG   B CD  1 
ATOM   3944 N  NE  . ARG   B 1 257 ? -43.15270 -1.69965  49.73762 1.000 42.35460 ? 257 ARG   B NE  1 
ATOM   3945 C  CZ  . ARG   B 1 257 ? -42.33360 -2.74444  49.70039 1.000 43.51143 ? 257 ARG   B CZ  1 
ATOM   3946 N  NH1 . ARG   B 1 257 ? -41.10618 -2.60784  49.21997 1.000 48.76845 ? 257 ARG   B NH1 1 
ATOM   3947 N  NH2 . ARG   B 1 257 ? -42.73789 -3.92571  50.14452 1.000 43.86552 ? 257 ARG   B NH2 1 
ATOM   3948 N  N   . GLN   B 1 258 ? -38.52094 2.90067   48.75968 1.000 26.67330 ? 258 GLN   B N   1 
ATOM   3949 C  CA  . GLN   B 1 258 ? -37.26234 3.13885   48.06531 1.000 26.09621 ? 258 GLN   B CA  1 
ATOM   3950 C  C   . GLN   B 1 258 ? -36.30929 3.97701   48.91008 1.000 26.99297 ? 258 GLN   B C   1 
ATOM   3951 O  O   . GLN   B 1 258 ? -35.10382 3.70345   48.95496 1.000 23.43545 ? 258 GLN   B O   1 
ATOM   3952 C  CB  . GLN   B 1 258 ? -37.56302 3.81189   46.72749 1.000 29.34143 ? 258 GLN   B CB  1 
ATOM   3953 C  CG  . GLN   B 1 258 ? -36.38304 4.34353   45.95634 1.000 35.40041 ? 258 GLN   B CG  1 
ATOM   3954 C  CD  . GLN   B 1 258 ? -36.83617 5.14284   44.75028 1.000 46.47464 ? 258 GLN   B CD  1 
ATOM   3955 O  OE1 . GLN   B 1 258 ? -37.69554 4.69846   43.98747 1.000 54.15358 ? 258 GLN   B OE1 1 
ATOM   3956 N  NE2 . GLN   B 1 258 ? -36.27696 6.33472   44.58233 1.000 43.91003 ? 258 GLN   B NE2 1 
ATOM   3957 N  N   . SER   B 1 259 ? -36.83231 4.99842   49.59388 1.000 22.60479 ? 259 SER   B N   1 
ATOM   3958 C  CA  . SER   B 1 259 ? -35.99255 5.81517   50.46553 1.000 24.05136 ? 259 SER   B CA  1 
ATOM   3959 C  C   . SER   B 1 259 ? -35.52145 5.02350   51.67865 1.000 23.01199 ? 259 SER   B C   1 
ATOM   3960 O  O   . SER   B 1 259 ? -34.35955 5.13440   52.08831 1.000 24.18123 ? 259 SER   B O   1 
ATOM   3961 C  CB  . SER   B 1 259 ? -36.75485 7.06513   50.90617 1.000 26.07847 ? 259 SER   B CB  1 
ATOM   3962 O  OG  . SER   B 1 259 ? -35.98661 7.84644   51.80557 1.000 24.77661 ? 259 SER   B OG  1 
ATOM   3963 N  N   . LEU   B 1 260 ? -36.41318 4.22509   52.26750 1.000 21.84296 ? 260 LEU   B N   1 
ATOM   3964 C  CA  . LEU   B 1 260 ? -36.04150 3.40193   53.41285 1.000 25.66088 ? 260 LEU   B CA  1 
ATOM   3965 C  C   . LEU   B 1 260 ? -34.94622 2.40993   53.04380 1.000 21.69690 ? 260 LEU   B C   1 
ATOM   3966 O  O   . LEU   B 1 260 ? -33.94683 2.27385   53.75969 1.000 20.06684 ? 260 LEU   B O   1 
ATOM   3967 C  CB  . LEU   B 1 260 ? -37.27353 2.66996   53.94079 1.000 21.66768 ? 260 LEU   B CB  1 
ATOM   3968 C  CG  . LEU   B 1 260 ? -37.02317 1.66591   55.05976 1.000 27.01323 ? 260 LEU   B CG  1 
ATOM   3969 C  CD1 . LEU   B 1 260 ? -36.35255 2.36235   56.19978 1.000 29.99792 ? 260 LEU   B CD1 1 
ATOM   3970 C  CD2 . LEU   B 1 260 ? -38.32631 1.05937   55.51497 1.000 31.06459 ? 260 LEU   B CD2 1 
ATOM   3971 N  N   . ARG   B 1 261 ? -35.12360 1.70528   51.92332 1.000 19.39448 ? 261 ARG   B N   1 
ATOM   3972 C  CA  . ARG   B 1 261 ? -34.13273 0.72785   51.48518 1.000 20.74666 ? 261 ARG   B CA  1 
ATOM   3973 C  C   . ARG   B 1 261 ? -32.75871 1.36431   51.31667 1.000 19.38928 ? 261 ARG   B C   1 
ATOM   3974 O  O   . ARG   B 1 261 ? -31.74787 0.79385   51.74317 1.000 19.73440 ? 261 ARG   B O   1 
ATOM   3975 C  CB  . ARG   B 1 261 ? -34.59194 0.07568   50.18131 1.000 16.69969 ? 261 ARG   B CB  1 
ATOM   3976 C  CG  . ARG   B 1 261 ? -33.53028 -0.75366  49.48769 1.000 18.20971 ? 261 ARG   B CG  1 
ATOM   3977 C  CD  . ARG   B 1 261 ? -34.13432 -1.60351  48.38421 1.000 19.43989 ? 261 ARG   B CD  1 
ATOM   3978 N  NE  . ARG   B 1 261 ? -33.10814 -2.28829  47.60498 1.000 19.62988 ? 261 ARG   B NE  1 
ATOM   3979 C  CZ  . ARG   B 1 261 ? -32.54440 -3.43857  47.95909 1.000 19.49911 ? 261 ARG   B CZ  1 
ATOM   3980 N  NH1 . ARG   B 1 261 ? -32.90402 -4.03564  49.08712 1.000 17.23998 ? 261 ARG   B NH1 1 
ATOM   3981 N  NH2 . ARG   B 1 261 ? -31.61741 -3.99031  47.18743 1.000 11.14453 ? 261 ARG   B NH2 1 
ATOM   3982 N  N   . LYS   B 1 262 ? -32.70101 2.55462   50.71324 1.000 15.93108 ? 262 LYS   B N   1 
ATOM   3983 C  CA  . LYS   B 1 262 ? -31.41406 3.21759   50.52521 1.000 20.74702 ? 262 LYS   B CA  1 
ATOM   3984 C  C   . LYS   B 1 262 ? -30.76913 3.57005   51.85944 1.000 19.86683 ? 262 LYS   B C   1 
ATOM   3985 O  O   . LYS   B 1 262 ? -29.56454 3.36269   52.04771 1.000 17.36496 ? 262 LYS   B O   1 
ATOM   3986 C  CB  . LYS   B 1 262 ? -31.57678 4.47516   49.67363 1.000 20.73031 ? 262 LYS   B CB  1 
ATOM   3987 C  CG  . LYS   B 1 262 ? -30.26104 5.20165   49.44723 1.000 23.29557 ? 262 LYS   B CG  1 
ATOM   3988 C  CD  . LYS   B 1 262 ? -30.44288 6.52842   48.73916 1.000 29.00159 ? 262 LYS   B CD  1 
ATOM   3989 C  CE  . LYS   B 1 262 ? -29.09273 7.14970   48.42514 1.000 34.85106 ? 262 LYS   B CE  1 
ATOM   3990 N  NZ  . LYS   B 1 262 ? -28.28507 6.26962   47.53350 1.000 32.90444 ? 262 LYS   B NZ  1 
ATOM   3991 N  N   . MET   B 1 263 ? -31.55239 4.10636   52.79815 1.000 18.86947 ? 263 MET   B N   1 
ATOM   3992 C  CA  . MET   B 1 263 ? -30.98668 4.50328   54.08358 1.000 21.25331 ? 263 MET   B CA  1 
ATOM   3993 C  C   . MET   B 1 263 ? -30.50875 3.29396   54.87789 1.000 18.32856 ? 263 MET   B C   1 
ATOM   3994 O  O   . MET   B 1 263 ? -29.44694 3.34296   55.50861 1.000 16.06370 ? 263 MET   B O   1 
ATOM   3995 C  CB  . MET   B 1 263 ? -32.00939 5.30837   54.88541 1.000 19.42311 ? 263 MET   B CB  1 
ATOM   3996 C  CG  . MET   B 1 263 ? -32.28625 6.69208   54.31422 1.000 23.19559 ? 263 MET   B CG  1 
ATOM   3997 S  SD  . MET   B 1 263 ? -33.30144 7.72408   55.39101 1.000 24.61243 ? 263 MET   B SD  1 
ATOM   3998 C  CE  . MET   B 1 263 ? -34.81586 6.77082   55.45072 1.000 16.78753 ? 263 MET   B CE  1 
ATOM   3999 N  N   . VAL   B 1 264 ? -31.27403 2.19993   54.85654 1.000 16.68345 ? 264 VAL   B N   1 
ATOM   4000 C  CA  . VAL   B 1 264 ? -30.86686 0.99109   55.57079 1.000 14.38997 ? 264 VAL   B CA  1 
ATOM   4001 C  C   . VAL   B 1 264 ? -29.55142 0.46375   55.01170 1.000 17.98872 ? 264 VAL   B C   1 
ATOM   4002 O  O   . VAL   B 1 264 ? -28.63783 0.09886   55.76199 1.000 14.42694 ? 264 VAL   B O   1 
ATOM   4003 C  CB  . VAL   B 1 264 ? -31.97583 -0.07433  55.50307 1.000 16.88152 ? 264 VAL   B CB  1 
ATOM   4004 C  CG1 . VAL   B 1 264 ? -31.47271 -1.40236  56.05012 1.000 13.69401 ? 264 VAL   B CG1 1 
ATOM   4005 C  CG2 . VAL   B 1 264 ? -33.19861 0.38807   56.27451 1.000 16.62718 ? 264 VAL   B CG2 1 
ATOM   4006 N  N   . ILE   B 1 265 ? -29.43691 0.42018   53.68214 1.000 17.85347 ? 265 ILE   B N   1 
ATOM   4007 C  CA  . ILE   B 1 265 ? -28.19648 -0.02251  53.04939 1.000 17.25211 ? 265 ILE   B CA  1 
ATOM   4008 C  C   . ILE   B 1 265 ? -27.03649 0.87003   53.47322 1.000 18.48060 ? 265 ILE   B C   1 
ATOM   4009 O  O   . ILE   B 1 265 ? -25.96457 0.38586   53.85586 1.000 18.08328 ? 265 ILE   B O   1 
ATOM   4010 C  CB  . ILE   B 1 265 ? -28.35584 -0.05054  51.51848 1.000 15.14350 ? 265 ILE   B CB  1 
ATOM   4011 C  CG1 . ILE   B 1 265 ? -29.32109 -1.16063  51.09912 1.000 12.60682 ? 265 ILE   B CG1 1 
ATOM   4012 C  CG2 . ILE   B 1 265 ? -27.00375 -0.22552  50.84302 1.000 16.45539 ? 265 ILE   B CG2 1 
ATOM   4013 C  CD1 . ILE   B 1 265 ? -29.68289 -1.12812  49.62953 1.000 14.03080 ? 265 ILE   B CD1 1 
ATOM   4014 N  N   . ASP   B 1 266 ? -27.23892 2.18971   53.41993 1.000 16.89140 ? 266 ASP   B N   1 
ATOM   4015 C  CA  . ASP   B 1 266 ? -26.17880 3.12125   53.79518 1.000 17.18244 ? 266 ASP   B CA  1 
ATOM   4016 C  C   . ASP   B 1 266 ? -25.75919 2.93370   55.24813 1.000 16.02121 ? 266 ASP   B C   1 
ATOM   4017 O  O   . ASP   B 1 266 ? -24.57642 3.06829   55.58270 1.000 15.44067 ? 266 ASP   B O   1 
ATOM   4018 C  CB  . ASP   B 1 266 ? -26.63497 4.56136   53.55653 1.000 21.13351 ? 266 ASP   B CB  1 
ATOM   4019 C  CG  . ASP   B 1 266 ? -26.72192 4.91139   52.08395 1.000 27.68496 ? 266 ASP   B CG  1 
ATOM   4020 O  OD1 . ASP   B 1 266 ? -25.99837 4.28796   51.27892 1.000 22.87779 ? 266 ASP   B OD1 1 
ATOM   4021 O  OD2 . ASP   B 1 266 ? -27.50954 5.81552   51.73251 1.000 31.35920 ? 266 ASP   B OD2 1 
ATOM   4022 N  N   . ILE   B 1 267 ? -26.71241 2.62093   56.12627 1.000 14.70712 ? 267 ILE   B N   1 
ATOM   4023 C  CA  . ILE   B 1 267 ? -26.39424 2.47963   57.54399 1.000 16.75460 ? 267 ILE   B CA  1 
ATOM   4024 C  C   . ILE   B 1 267 ? -25.62674 1.18719   57.79723 1.000 15.79102 ? 267 ILE   B C   1 
ATOM   4025 O  O   . ILE   B 1 267 ? -24.56455 1.19296   58.43034 1.000 16.74411 ? 267 ILE   B O   1 
ATOM   4026 C  CB  . ILE   B 1 267 ? -27.67540 2.54989   58.39348 1.000 20.13696 ? 267 ILE   B CB  1 
ATOM   4027 C  CG1 . ILE   B 1 267 ? -28.28231 3.95367   58.33552 1.000 22.05482 ? 267 ILE   B CG1 1 
ATOM   4028 C  CG2 . ILE   B 1 267 ? -27.37600 2.16377   59.82920 1.000 13.90418 ? 267 ILE   B CG2 1 
ATOM   4029 C  CD1 . ILE   B 1 267 ? -29.67923 4.04038   58.91463 1.000 16.60530 ? 267 ILE   B CD1 1 
ATOM   4030 N  N   . VAL   B 1 268 ? -26.15096 0.06095   57.30772 1.000 13.90744 ? 268 VAL   B N   1 
ATOM   4031 C  CA  . VAL   B 1 268 ? -25.54385 -1.23233  57.61240 1.000 14.60106 ? 268 VAL   B CA  1 
ATOM   4032 C  C   . VAL   B 1 268 ? -24.15938 -1.34305  56.98462 1.000 14.26056 ? 268 VAL   B C   1 
ATOM   4033 O  O   . VAL   B 1 268 ? -23.23560 -1.90475  57.58677 1.000 16.25635 ? 268 VAL   B O   1 
ATOM   4034 C  CB  . VAL   B 1 268 ? -26.46739 -2.37808  57.16182 1.000 14.39645 ? 268 VAL   B CB  1 
ATOM   4035 C  CG1 . VAL   B 1 268 ? -25.79046 -3.72356  57.37466 1.000 15.73755 ? 268 VAL   B CG1 1 
ATOM   4036 C  CG2 . VAL   B 1 268 ? -27.78469 -2.32321  57.92086 1.000 14.83906 ? 268 VAL   B CG2 1 
ATOM   4037 N  N   . LEU   B 1 269 ? -23.98693 -0.81030  55.77119 1.000 13.16095 ? 269 LEU   B N   1 
ATOM   4038 C  CA  . LEU   B 1 269 ? -22.66124 -0.80768  55.16010 1.000 17.76815 ? 269 LEU   B CA  1 
ATOM   4039 C  C   . LEU   B 1 269 ? -21.65527 -0.04931  56.01526 1.000 16.41192 ? 269 LEU   B C   1 
ATOM   4040 O  O   . LEU   B 1 269 ? -20.46735 -0.39055  56.02563 1.000 17.49662 ? 269 LEU   B O   1 
ATOM   4041 C  CB  . LEU   B 1 269 ? -22.72023 -0.20759  53.75386 1.000 17.65388 ? 269 LEU   B CB  1 
ATOM   4042 C  CG  . LEU   B 1 269 ? -23.32097 -1.08213  52.65078 1.000 17.98323 ? 269 LEU   B CG  1 
ATOM   4043 C  CD1 . LEU   B 1 269 ? -23.16050 -0.41703  51.28945 1.000 14.84847 ? 269 LEU   B CD1 1 
ATOM   4044 C  CD2 . LEU   B 1 269 ? -22.69064 -2.46646  52.65401 1.000 14.96302 ? 269 LEU   B CD2 1 
ATOM   4045 N  N   . ALA   B 1 270 ? -22.11058 0.96476   56.75086 1.000 16.54277 ? 270 ALA   B N   1 
ATOM   4046 C  CA  . ALA   B 1 270 ? -21.22412 1.75274   57.59535 1.000 16.62373 ? 270 ALA   B CA  1 
ATOM   4047 C  C   . ALA   B 1 270 ? -20.86066 1.06014   58.90297 1.000 18.77393 ? 270 ALA   B C   1 
ATOM   4048 O  O   . ALA   B 1 270 ? -20.01068 1.57593   59.63641 1.000 17.30400 ? 270 ALA   B O   1 
ATOM   4049 C  CB  . ALA   B 1 270 ? -21.85694 3.11097   57.89776 1.000 19.45378 ? 270 ALA   B CB  1 
ATOM   4050 N  N   . THR   B 1 271 ? -21.47716 -0.07875  59.22345 1.000 15.57170 ? 271 THR   B N   1 
ATOM   4051 C  CA  . THR   B 1 271 ? -21.07464 -0.82265  60.41081 1.000 18.42912 ? 271 THR   B CA  1 
ATOM   4052 C  C   . THR   B 1 271 ? -19.77808 -1.59535  60.20377 1.000 20.81292 ? 271 THR   B C   1 
ATOM   4053 O  O   . THR   B 1 271 ? -19.19427 -2.06853  61.18519 1.000 24.86671 ? 271 THR   B O   1 
ATOM   4054 C  CB  . THR   B 1 271 ? -22.18563 -1.78388  60.84409 1.000 19.59127 ? 271 THR   B CB  1 
ATOM   4055 O  OG1 . THR   B 1 271 ? -22.38832 -2.77688  59.83122 1.000 14.79705 ? 271 THR   B OG1 1 
ATOM   4056 C  CG2 . THR   B 1 271 ? -23.48692 -1.02456  61.07551 1.000 18.32914 ? 271 THR   B CG2 1 
ATOM   4057 N  N   . ASP   B 1 272 ? -19.32745 -1.73301  58.95764 1.000 18.03761 ? 272 ASP   B N   1 
ATOM   4058 C  CA  . ASP   B 1 272 ? -18.03458 -2.33553  58.65653 1.000 16.63966 ? 272 ASP   B CA  1 
ATOM   4059 C  C   . ASP   B 1 272 ? -16.92453 -1.56870  59.36693 1.000 24.63994 ? 272 ASP   B C   1 
ATOM   4060 O  O   . ASP   B 1 272 ? -16.73910 -0.37103  59.13085 1.000 21.49900 ? 272 ASP   B O   1 
ATOM   4061 C  CB  . ASP   B 1 272 ? -17.81680 -2.32913  57.14121 1.000 17.87685 ? 272 ASP   B CB  1 
ATOM   4062 C  CG  . ASP   B 1 272 ? -16.56667 -3.08279  56.70938 1.000 22.98236 ? 272 ASP   B CG  1 
ATOM   4063 O  OD1 . ASP   B 1 272 ? -15.72982 -3.43506  57.56670 1.000 19.39240 ? 272 ASP   B OD1 1 
ATOM   4064 O  OD2 . ASP   B 1 272 ? -16.42074 -3.31764  55.49075 1.000 17.97954 ? 272 ASP   B OD2 1 
ATOM   4065 N  N   . MET   B 1 273 ? -16.17945 -2.26590  60.23260 1.000 19.51394 ? 273 MET   B N   1 
ATOM   4066 C  CA  . MET   B 1 273 ? -15.13842 -1.60423  61.01622 1.000 22.27352 ? 273 MET   B CA  1 
ATOM   4067 C  C   . MET   B 1 273 ? -14.03315 -1.03782  60.13649 1.000 23.62778 ? 273 MET   B C   1 
ATOM   4068 O  O   . MET   B 1 273 ? -13.33749 -0.10134  60.54601 1.000 22.97734 ? 273 MET   B O   1 
ATOM   4069 C  CB  . MET   B 1 273 ? -14.54369 -2.56773  62.04390 1.000 24.63712 ? 273 MET   B CB  1 
ATOM   4070 C  CG  . MET   B 1 273 ? -15.08411 -2.38800  63.45746 1.000 31.37607 ? 273 MET   B CG  1 
ATOM   4071 S  SD  . MET   B 1 273 ? -14.71192 -0.77473  64.17667 1.000 29.80922 ? 273 MET   B SD  1 
ATOM   4072 C  CE  . MET   B 1 273 ? -12.94238 -0.67440  63.90946 1.000 26.09520 ? 273 MET   B CE  1 
ATOM   4073 N  N   . SER   B 1 274 ? -13.84718 -1.58625  58.93333 1.000 22.59702 ? 274 SER   B N   1 
ATOM   4074 C  CA  . SER   B 1 274 ? -12.83790 -1.04289  58.03195 1.000 22.82954 ? 274 SER   B CA  1 
ATOM   4075 C  C   . SER   B 1 274 ? -13.15801 0.38034   57.59347 1.000 24.87005 ? 274 SER   B C   1 
ATOM   4076 O  O   . SER   B 1 274 ? -12.28620 1.04777   57.02611 1.000 25.48855 ? 274 SER   B O   1 
ATOM   4077 C  CB  . SER   B 1 274 ? -12.68059 -1.94637  56.80579 1.000 25.84114 ? 274 SER   B CB  1 
ATOM   4078 O  OG  . SER   B 1 274 ? -13.79929 -1.84479  55.94345 1.000 24.46705 ? 274 SER   B OG  1 
ATOM   4079 N  N   . LYS   B 1 275 ? -14.37445 0.85963   57.84887 1.000 21.50002 ? 275 LYS   B N   1 
ATOM   4080 C  CA  . LYS   B 1 275 ? -14.77415 2.22551   57.54417 1.000 25.47732 ? 275 LYS   B CA  1 
ATOM   4081 C  C   . LYS   B 1 275 ? -14.82554 3.11109   58.78296 1.000 30.19639 ? 275 LYS   B C   1 
ATOM   4082 O  O   . LYS   B 1 275 ? -15.30745 4.24501   58.69853 1.000 27.13710 ? 275 LYS   B O   1 
ATOM   4083 C  CB  . LYS   B 1 275 ? -16.13823 2.23095   56.85186 1.000 23.75314 ? 275 LYS   B CB  1 
ATOM   4084 C  CG  . LYS   B 1 275 ? -16.17596 1.47436   55.53708 1.000 26.31521 ? 275 LYS   B CG  1 
ATOM   4085 C  CD  . LYS   B 1 275 ? -17.60051 1.33589   55.02780 1.000 30.15441 ? 275 LYS   B CD  1 
ATOM   4086 C  CE  . LYS   B 1 275 ? -17.65851 0.46797   53.78115 1.000 26.21518 ? 275 LYS   B CE  1 
ATOM   4087 N  NZ  . LYS   B 1 275 ? -19.00612 -0.13891  53.59269 1.000 23.32819 ? 275 LYS   B NZ  1 
ATOM   4088 N  N   . HIS   B 1 276 ? -14.34195 2.61962   59.92823 1.000 24.25688 ? 276 HIS   B N   1 
ATOM   4089 C  CA  . HIS   B 1 276 ? -14.46382 3.37170   61.17499 1.000 26.26897 ? 276 HIS   B CA  1 
ATOM   4090 C  C   . HIS   B 1 276 ? -13.75951 4.72006   61.09431 1.000 21.83550 ? 276 HIS   B C   1 
ATOM   4091 O  O   . HIS   B 1 276 ? -14.30051 5.73700   61.54394 1.000 26.51391 ? 276 HIS   B O   1 
ATOM   4092 C  CB  . HIS   B 1 276 ? -13.90248 2.55588   62.33974 1.000 24.44638 ? 276 HIS   B CB  1 
ATOM   4093 C  CG  . HIS   B 1 276 ? -13.68491 3.35583   63.58754 1.000 25.24296 ? 276 HIS   B CG  1 
ATOM   4094 N  ND1 . HIS   B 1 276 ? -14.71099 3.70244   64.43893 1.000 22.25904 ? 276 HIS   B ND1 1 
ATOM   4095 C  CD2 . HIS   B 1 276 ? -12.55877 3.88234   64.12450 1.000 23.07696 ? 276 HIS   B CD2 1 
ATOM   4096 C  CE1 . HIS   B 1 276 ? -14.22774 4.40345   65.44848 1.000 24.63835 ? 276 HIS   B CE1 1 
ATOM   4097 N  NE2 . HIS   B 1 276 ? -12.92376 4.52793   65.28116 1.000 26.29625 ? 276 HIS   B NE2 1 
ATOM   4098 N  N   . MET   B 1 277 ? -12.55372 4.75039   60.52338 1.000 24.72614 ? 277 MET   B N   1 
ATOM   4099 C  CA  . MET   B 1 277 ? -11.74307 5.96428   60.56905 1.000 30.77265 ? 277 MET   B CA  1 
ATOM   4100 C  C   . MET   B 1 277 ? -12.35065 7.07768   59.72072 1.000 29.34900 ? 277 MET   B C   1 
ATOM   4101 O  O   . MET   B 1 277 ? -12.49233 8.21375   60.18906 1.000 28.33245 ? 277 MET   B O   1 
ATOM   4102 C  CB  . MET   B 1 277 ? -10.31250 5.65616   60.12665 1.000 28.81619 ? 277 MET   B CB  1 
ATOM   4103 C  CG  . MET   B 1 277 ? -9.53011  4.78624   61.10667 1.000 36.64442 ? 277 MET   B CG  1 
ATOM   4104 S  SD  . MET   B 1 277 ? -9.46208  5.47198   62.77588 1.000 46.72841 ? 277 MET   B SD  1 
ATOM   4105 C  CE  . MET   B 1 277 ? -8.19527  4.44495   63.51962 1.000 45.15296 ? 277 MET   B CE  1 
ATOM   4106 N  N   . ASN   B 1 278 ? -12.70092 6.77755   58.46453 1.000 34.18049 ? 278 ASN   B N   1 
ATOM   4107 C  CA  . ASN   B 1 278 ? -13.39851 7.75642   57.63173 1.000 30.84945 ? 278 ASN   B CA  1 
ATOM   4108 C  C   . ASN   B 1 278 ? -14.63306 8.28862   58.34344 1.000 31.15799 ? 278 ASN   B C   1 
ATOM   4109 O  O   . ASN   B 1 278 ? -14.85137 9.50275   58.42681 1.000 29.83809 ? 278 ASN   B O   1 
ATOM   4110 C  CB  . ASN   B 1 278 ? -13.81572 7.13195   56.29774 1.000 31.80647 ? 278 ASN   B CB  1 
ATOM   4111 C  CG  . ASN   B 1 278 ? -12.65089 6.58746   55.50666 1.000 41.94460 ? 278 ASN   B CG  1 
ATOM   4112 O  OD1 . ASN   B 1 278 ? -11.52587 7.07343   55.61186 1.000 43.07765 ? 278 ASN   B OD1 1 
ATOM   4113 N  ND2 . ASN   B 1 278 ? -12.92023 5.57287   54.69291 1.000 42.20522 ? 278 ASN   B ND2 1 
ATOM   4114 N  N   . LEU   B 1 279 ? -15.45073 7.37301   58.86509 1.000 33.79963 ? 279 LEU   B N   1 
ATOM   4115 C  CA  . LEU   B 1 279 ? -16.71130 7.73710   59.50009 1.000 28.42887 ? 279 LEU   B CA  1 
ATOM   4116 C  C   . LEU   B 1 279 ? -16.48577 8.64876   60.69989 1.000 33.22087 ? 279 LEU   B C   1 
ATOM   4117 O  O   . LEU   B 1 279 ? -17.27202 9.57124   60.94698 1.000 35.09865 ? 279 LEU   B O   1 
ATOM   4118 C  CB  . LEU   B 1 279 ? -17.44066 6.45888   59.91210 1.000 27.63221 ? 279 LEU   B CB  1 
ATOM   4119 C  CG  . LEU   B 1 279 ? -18.92138 6.45045   60.27368 1.000 34.59881 ? 279 LEU   B CG  1 
ATOM   4120 C  CD1 . LEU   B 1 279 ? -19.75469 6.98299   59.12420 1.000 31.45998 ? 279 LEU   B CD1 1 
ATOM   4121 C  CD2 . LEU   B 1 279 ? -19.33586 5.03056   60.61962 1.000 31.88164 ? 279 LEU   B CD2 1 
ATOM   4122 N  N   . LEU   B 1 280 ? -15.41236 8.40637   61.45499 1.000 35.85636 ? 280 LEU   B N   1 
ATOM   4123 C  CA  . LEU   B 1 280 ? -15.09440 9.24150   62.60747 1.000 35.64168 ? 280 LEU   B CA  1 
ATOM   4124 C  C   . LEU   B 1 280 ? -14.53900 10.59461  62.18031 1.000 32.39129 ? 280 LEU   B C   1 
ATOM   4125 O  O   . LEU   B 1 280 ? -14.85140 11.61905  62.79814 1.000 30.93498 ? 280 LEU   B O   1 
ATOM   4126 C  CB  . LEU   B 1 280 ? -14.10114 8.51669   63.51608 1.000 33.82881 ? 280 LEU   B CB  1 
ATOM   4127 C  CG  . LEU   B 1 280 ? -13.59060 9.26982   64.74469 1.000 37.23789 ? 280 LEU   B CG  1 
ATOM   4128 C  CD1 . LEU   B 1 280 ? -14.72751 9.54684   65.71393 1.000 30.48670 ? 280 LEU   B CD1 1 
ATOM   4129 C  CD2 . LEU   B 1 280 ? -12.48164 8.48198   65.42243 1.000 29.27893 ? 280 LEU   B CD2 1 
ATOM   4130 N  N   . ALA   B 1 281 ? -13.71160 10.61482  61.13167 1.000 33.21452 ? 281 ALA   B N   1 
ATOM   4131 C  CA  . ALA   B 1 281 ? -13.21667 11.88059  60.60070 1.000 34.01853 ? 281 ALA   B CA  1 
ATOM   4132 C  C   . ALA   B 1 281 ? -14.36637 12.78441  60.17506 1.000 40.79466 ? 281 ALA   B C   1 
ATOM   4133 O  O   . ALA   B 1 281 ? -14.34598 13.99340  60.43595 1.000 41.78335 ? 281 ALA   B O   1 
ATOM   4134 C  CB  . ALA   B 1 281 ? -12.27266 11.62216  59.42668 1.000 34.48123 ? 281 ALA   B CB  1 
ATOM   4135 N  N   . ASP   B 1 282 ? -15.38496 12.21291  59.52768 1.000 36.67990 ? 282 ASP   B N   1 
ATOM   4136 C  CA  . ASP   B 1 282 ? -16.54020 13.00642  59.12145 1.000 42.49938 ? 282 ASP   B CA  1 
ATOM   4137 C  C   . ASP   B 1 282 ? -17.33716 13.47919  60.32986 1.000 39.88334 ? 282 ASP   B C   1 
ATOM   4138 O  O   . ASP   B 1 282 ? -17.81217 14.62051  60.35796 1.000 40.12808 ? 282 ASP   B O   1 
ATOM   4139 C  CB  . ASP   B 1 282 ? -17.42769 12.19865  58.17494 1.000 41.34947 ? 282 ASP   B CB  1 
ATOM   4140 C  CG  . ASP   B 1 282 ? -16.80045 12.01078  56.80829 1.000 45.84598 ? 282 ASP   B CG  1 
ATOM   4141 O  OD1 . ASP   B 1 282 ? -15.77638 12.67027  56.53046 1.000 39.84522 ? 282 ASP   B OD1 1 
ATOM   4142 O  OD2 . ASP   B 1 282 ? -17.33074 11.20718  56.01210 1.000 43.11834 ? 282 ASP   B OD2 1 
ATOM   4143 N  N   . LEU   B 1 283 ? -17.49826 12.61434  61.33531 1.000 38.96674 ? 283 LEU   B N   1 
ATOM   4144 C  CA  . LEU   B 1 283 ? -18.17807 13.02210  62.55999 1.000 34.23720 ? 283 LEU   B CA  1 
ATOM   4145 C  C   . LEU   B 1 283 ? -17.42765 14.14676  63.26112 1.000 40.06370 ? 283 LEU   B C   1 
ATOM   4146 O  O   . LEU   B 1 283 ? -18.05052 15.02440  63.86990 1.000 42.31246 ? 283 LEU   B O   1 
ATOM   4147 C  CB  . LEU   B 1 283 ? -18.33835 11.82069  63.49329 1.000 36.07009 ? 283 LEU   B CB  1 
ATOM   4148 C  CG  . LEU   B 1 283 ? -19.28823 11.95421  64.68515 1.000 31.50501 ? 283 LEU   B CG  1 
ATOM   4149 C  CD1 . LEU   B 1 283 ? -20.73849 11.93164  64.22550 1.000 33.67563 ? 283 LEU   B CD1 1 
ATOM   4150 C  CD2 . LEU   B 1 283 ? -19.02762 10.85099  65.70068 1.000 32.99371 ? 283 LEU   B CD2 1 
ATOM   4151 N  N   . LYS   B 1 284 ? -16.09451 14.14107  63.18173 1.000 36.64960 ? 284 LYS   B N   1 
ATOM   4152 C  CA  . LYS   B 1 284 ? -15.30852 15.23250  63.74882 1.000 40.22130 ? 284 LYS   B CA  1 
ATOM   4153 C  C   . LYS   B 1 284 ? -15.50539 16.51903  62.95787 1.000 43.96040 ? 284 LYS   B C   1 
ATOM   4154 O  O   . LYS   B 1 284 ? -15.66914 17.59775  63.54003 1.000 45.60059 ? 284 LYS   B O   1 
ATOM   4155 C  CB  . LYS   B 1 284 ? -13.82881 14.85235  63.78734 1.000 35.28269 ? 284 LYS   B CB  1 
ATOM   4156 C  CG  . LYS   B 1 284 ? -13.45920 13.88593  64.89267 1.000 40.97213 ? 284 LYS   B CG  1 
ATOM   4157 C  CD  . LYS   B 1 284 ? -11.97061 13.59798  64.88504 1.000 36.15622 ? 284 LYS   B CD  1 
ATOM   4158 C  CE  . LYS   B 1 284 ? -11.59954 12.60733  65.97317 1.000 40.59528 ? 284 LYS   B CE  1 
ATOM   4159 N  NZ  . LYS   B 1 284 ? -10.16309 12.22120  65.91278 1.000 36.01111 ? 284 LYS   B NZ  1 
ATOM   4160 N  N   . THR   B 1 285 ? -15.47339 16.42549  61.62576 1.000 40.50876 ? 285 THR   B N   1 
ATOM   4161 C  CA  . THR   B 1 285 ? -15.71887 17.59757  60.79097 1.000 43.70819 ? 285 THR   B CA  1 
ATOM   4162 C  C   . THR   B 1 285 ? -17.07939 18.20599  61.10044 1.000 42.45327 ? 285 THR   B C   1 
ATOM   4163 O  O   . THR   B 1 285 ? -17.20752 19.42539  61.26131 1.000 44.82246 ? 285 THR   B O   1 
ATOM   4164 C  CB  . THR   B 1 285 ? -15.62511 17.22118  59.31179 1.000 36.40276 ? 285 THR   B CB  1 
ATOM   4165 O  OG1 . THR   B 1 285 ? -14.31796 16.70654  59.02962 1.000 39.05203 ? 285 THR   B OG1 1 
ATOM   4166 C  CG2 . THR   B 1 285 ? -15.88624 18.43780  58.43392 1.000 47.84368 ? 285 THR   B CG2 1 
ATOM   4167 N  N   . MET   B 1 286 ? -18.10922 17.36201  61.20229 1.000 33.46910 ? 286 MET   B N   1 
ATOM   4168 C  CA  . MET   B 1 286 ? -19.42807 17.85128  61.58320 1.000 35.32122 ? 286 MET   B CA  1 
ATOM   4169 C  C   . MET   B 1 286 ? -19.41057 18.47729  62.97190 1.000 45.17827 ? 286 MET   B C   1 
ATOM   4170 O  O   . MET   B 1 286 ? -20.23475 19.34667  63.26870 1.000 47.06066 ? 286 MET   B O   1 
ATOM   4171 C  CB  . MET   B 1 286 ? -20.45179 16.71636  61.51459 1.000 37.16552 ? 286 MET   B CB  1 
ATOM   4172 C  CG  . MET   B 1 286 ? -21.75551 17.01536  62.23543 1.000 36.84227 ? 286 MET   B CG  1 
ATOM   4173 S  SD  . MET   B 1 286 ? -23.13683 16.02078  61.67605 1.000 51.81104 ? 286 MET   B SD  1 
ATOM   4174 C  CE  . MET   B 1 286 ? -22.85279 16.03322  59.91498 1.000 45.19418 ? 286 MET   B CE  1 
ATOM   4175 N  N   . VAL   B 1 287 ? -18.47617 18.06611  63.82995 1.000 40.58391 ? 287 VAL   B N   1 
ATOM   4176 C  CA  . VAL   B 1 287 ? -18.37499 18.67603  65.15200 1.000 42.15820 ? 287 VAL   B CA  1 
ATOM   4177 C  C   . VAL   B 1 287 ? -17.72359 20.05305  65.06886 1.000 41.30435 ? 287 VAL   B C   1 
ATOM   4178 O  O   . VAL   B 1 287 ? -18.16770 21.00118  65.72600 1.000 43.08204 ? 287 VAL   B O   1 
ATOM   4179 C  CB  . VAL   B 1 287 ? -17.61686 17.74134  66.11198 1.000 45.77153 ? 287 VAL   B CB  1 
ATOM   4180 C  CG1 . VAL   B 1 287 ? -16.99403 18.53446  67.24813 1.000 45.40578 ? 287 VAL   B CG1 1 
ATOM   4181 C  CG2 . VAL   B 1 287 ? -18.55589 16.67999  66.66086 1.000 35.13552 ? 287 VAL   B CG2 1 
ATOM   4182 N  N   . GLU   B 1 288 ? -16.66582 20.19216  64.26642 1.000 41.17368 ? 288 GLU   B N   1 
ATOM   4183 C  CA  . GLU   B 1 288 ? -16.00876 21.48977  64.13523 1.000 47.78598 ? 288 GLU   B CA  1 
ATOM   4184 C  C   . GLU   B 1 288 ? -16.92954 22.50606  63.47187 1.000 51.06113 ? 288 GLU   B C   1 
ATOM   4185 O  O   . GLU   B 1 288 ? -17.15315 23.59917  64.00503 1.000 52.32625 ? 288 GLU   B O   1 
ATOM   4186 C  CB  . GLU   B 1 288 ? -14.71123 21.34950  63.34083 1.000 50.55237 ? 288 GLU   B CB  1 
ATOM   4187 C  CG  . GLU   B 1 288 ? -13.66999 20.45226  63.97880 1.000 51.28716 ? 288 GLU   B CG  1 
ATOM   4188 C  CD  . GLU   B 1 288 ? -12.35378 20.48648  63.23065 1.000 61.69399 ? 288 GLU   B CD  1 
ATOM   4189 O  OE1 . GLU   B 1 288 ? -11.35479 20.96976  63.80366 1.000 65.58831 ? 288 GLU   B OE1 1 
ATOM   4190 O  OE2 . GLU   B 1 288 ? -12.32239 20.04270  62.06332 1.000 56.87647 ? 288 GLU   B OE2 1 
ATOM   4191 N  N   . THR   B 1 289 ? -17.47018 22.16332  62.30389 1.000 50.31843 ? 289 THR   B N   1 
ATOM   4192 C  CA  . THR   B 1 289 ? -18.40578 23.01835  61.58633 1.000 50.36627 ? 289 THR   B CA  1 
ATOM   4193 C  C   . THR   B 1 289 ? -19.83863 22.87468  62.09051 1.000 47.52853 ? 289 THR   B C   1 
ATOM   4194 O  O   . THR   B 1 289 ? -20.77430 23.28344  61.39199 1.000 50.08307 ? 289 THR   B O   1 
ATOM   4195 C  CB  . THR   B 1 289 ? -18.34334 22.71937  60.08660 1.000 48.93423 ? 289 THR   B CB  1 
ATOM   4196 O  OG1 . THR   B 1 289 ? -18.91989 21.43301  59.82959 1.000 49.45042 ? 289 THR   B OG1 1 
ATOM   4197 C  CG2 . THR   B 1 289 ? -16.89800 22.71779  59.61031 1.000 47.72746 ? 289 THR   B CG2 1 
ATOM   4198 N  N   . LYS   B 1 290 ? -20.00686 22.30401  63.28372 1.000 42.93138 ? 290 LYS   B N   1 
ATOM   4199 C  CA  . LYS   B 1 290 ? -21.32026 22.10676  63.88376 1.000 46.05709 ? 290 LYS   B CA  1 
ATOM   4200 C  C   . LYS   B 1 290 ? -22.11424 23.40404  63.92340 1.000 47.51509 ? 290 LYS   B C   1 
ATOM   4201 O  O   . LYS   B 1 290 ? -21.57101 24.47973  64.18759 1.000 45.72125 ? 290 LYS   B O   1 
ATOM   4202 C  CB  . LYS   B 1 290 ? -21.14705 21.54445  65.29815 1.000 45.78307 ? 290 LYS   B CB  1 
ATOM   4203 C  CG  . LYS   B 1 290 ? -22.39426 21.45873  66.15369 1.000 47.50262 ? 290 LYS   B CG  1 
ATOM   4204 C  CD  . LYS   B 1 290 ? -22.02101 20.96079  67.54734 1.000 50.28085 ? 290 LYS   B CD  1 
ATOM   4205 C  CE  . LYS   B 1 290 ? -23.22980 20.83963  68.45982 1.000 47.54232 ? 290 LYS   B CE  1 
ATOM   4206 N  NZ  . LYS   B 1 290 ? -22.83687 20.45388  69.84506 1.000 48.55966 ? 290 LYS   B NZ  1 
ATOM   4207 N  N   . LYS   B 1 291 ? -23.40892 23.29279  63.63940 1.000 50.92003 ? 291 LYS   B N   1 
ATOM   4208 C  CA  . LYS   B 1 291 ? -24.33877 24.40268  63.75867 1.000 49.50045 ? 291 LYS   B CA  1 
ATOM   4209 C  C   . LYS   B 1 291 ? -25.50739 23.97224  64.62785 1.000 46.26919 ? 291 LYS   B C   1 
ATOM   4210 O  O   . LYS   B 1 291 ? -25.94115 22.81729  64.59147 1.000 41.81011 ? 291 LYS   B O   1 
ATOM   4211 C  CB  . LYS   B 1 291 ? -24.84340 24.87492  62.39819 1.000 44.16592 ? 291 LYS   B CB  1 
ATOM   4212 C  CG  . LYS   B 1 291 ? -23.78914 25.56829  61.56340 1.000 49.95779 ? 291 LYS   B CG  1 
ATOM   4213 C  CD  . LYS   B 1 291 ? -24.02709 25.31564  60.08864 1.000 48.49629 ? 291 LYS   B CD  1 
ATOM   4214 C  CE  . LYS   B 1 291 ? -23.11215 26.16311  59.22836 1.000 45.24234 ? 291 LYS   B CE  1 
ATOM   4215 N  NZ  . LYS   B 1 291 ? -21.75559 25.56398  59.13418 1.000 46.60506 ? 291 LYS   B NZ  1 
ATOM   4216 N  N   . VAL   B 1 292 ? -26.02307 24.92035  65.40340 1.000 40.64517 ? 292 VAL   B N   1 
ATOM   4217 C  CA  . VAL   B 1 292 ? -26.88838 24.58893  66.52293 1.000 41.57865 ? 292 VAL   B CA  1 
ATOM   4218 C  C   . VAL   B 1 292 ? -27.76865 25.79013  66.83113 1.000 45.53070 ? 292 VAL   B C   1 
ATOM   4219 O  O   . VAL   B 1 292 ? -27.35745 26.94193  66.66760 1.000 46.27533 ? 292 VAL   B O   1 
ATOM   4220 C  CB  . VAL   B 1 292 ? -26.02748 24.16014  67.73911 1.000 48.02078 ? 292 VAL   B CB  1 
ATOM   4221 C  CG1 . VAL   B 1 292 ? -24.97287 25.21284  68.05161 1.000 44.42269 ? 292 VAL   B CG1 1 
ATOM   4222 C  CG2 . VAL   B 1 292 ? -26.86969 23.87949  68.95366 1.000 48.79989 ? 292 VAL   B CG2 1 
ATOM   4223 N  N   . THR   B 1 293 ? -29.00355 25.51485  67.24186 1.000 41.55439 ? 293 THR   B N   1 
ATOM   4224 C  CA  . THR   B 1 293 ? -29.82289 26.55118  67.85069 1.000 50.33542 ? 293 THR   B CA  1 
ATOM   4225 C  C   . THR   B 1 293 ? -29.16214 27.03311  69.13688 1.000 57.72643 ? 293 THR   B C   1 
ATOM   4226 O  O   . THR   B 1 293 ? -28.40716 26.30082  69.77859 1.000 56.39143 ? 293 THR   B O   1 
ATOM   4227 C  CB  . THR   B 1 293 ? -31.22016 26.01102  68.15302 1.000 52.86778 ? 293 THR   B CB  1 
ATOM   4228 O  OG1 . THR   B 1 293 ? -31.14393 25.09379  69.25260 1.000 49.54677 ? 293 THR   B OG1 1 
ATOM   4229 C  CG2 . THR   B 1 293 ? -31.77550 25.28454  66.94209 1.000 43.76533 ? 293 THR   B CG2 1 
ATOM   4230 N  N   . SER   B 1 294 ? -29.44226 28.28057  69.52253 1.000 60.82523 ? 294 SER   B N   1 
ATOM   4231 C  CA  . SER   B 1 294 ? -28.94185 28.73995  70.81337 1.000 63.42945 ? 294 SER   B CA  1 
ATOM   4232 C  C   . SER   B 1 294 ? -29.45967 27.86453  71.94659 1.000 65.96027 ? 294 SER   B C   1 
ATOM   4233 O  O   . SER   B 1 294 ? -28.82580 27.79211  73.00642 1.000 67.54743 ? 294 SER   B O   1 
ATOM   4234 C  CB  . SER   B 1 294 ? -29.32684 30.20207  71.05510 1.000 61.60704 ? 294 SER   B CB  1 
ATOM   4235 O  OG  . SER   B 1 294 ? -30.70943 30.32356  71.33042 1.000 56.66071 ? 294 SER   B OG  1 
ATOM   4236 N  N   . SER   B 1 295 ? -30.57879 27.17613  71.72188 1.000 64.53070 ? 295 SER   B N   1 
ATOM   4237 C  CA  . SER   B 1 295 ? -31.20162 26.23786  72.65416 1.000 64.67155 ? 295 SER   B CA  1 
ATOM   4238 C  C   . SER   B 1 295 ? -30.68806 24.81127  72.48287 1.000 65.15414 ? 295 SER   B C   1 
ATOM   4239 O  O   . SER   B 1 295 ? -31.47385 23.85911  72.50627 1.000 65.53329 ? 295 SER   B O   1 
ATOM   4240 C  CB  . SER   B 1 295 ? -32.71738 26.28934  72.47878 1.000 64.15706 ? 295 SER   B CB  1 
ATOM   4241 O  OG  . SER   B 1 295 ? -33.06101 26.39327  71.10723 1.000 59.40417 ? 295 SER   B OG  1 
ATOM   4242 N  N   . GLY   B 1 296 ? -29.38566 24.62424  72.28195 1.000 63.08130 ? 296 GLY   B N   1 
ATOM   4243 C  CA  . GLY   B 1 296 ? -28.78738 23.30255  72.32728 1.000 64.94932 ? 296 GLY   B CA  1 
ATOM   4244 C  C   . GLY   B 1 296 ? -28.94357 22.40866  71.10894 1.000 60.33546 ? 296 GLY   B C   1 
ATOM   4245 O  O   . GLY   B 1 296 ? -28.02408 21.65223  70.77585 1.000 60.59657 ? 296 GLY   B O   1 
ATOM   4246 N  N   . VAL   B 1 297 ? -30.08290 22.49113  70.41950 1.000 58.92652 ? 297 VAL   B N   1 
ATOM   4247 C  CA  . VAL   B 1 297 ? -30.42705 21.48026  69.42271 1.000 50.76370 ? 297 VAL   B CA  1 
ATOM   4248 C  C   . VAL   B 1 297 ? -29.65193 21.70254  68.12516 1.000 51.87603 ? 297 VAL   B C   1 
ATOM   4249 O  O   . VAL   B 1 297 ? -29.43394 22.84059  67.68165 1.000 47.05502 ? 297 VAL   B O   1 
ATOM   4250 C  CB  . VAL   B 1 297 ? -31.94442 21.46936  69.17718 1.000 47.27636 ? 297 VAL   B CB  1 
ATOM   4251 C  CG1 . VAL   B 1 297 ? -32.29842 20.47070  68.08408 1.000 40.49810 ? 297 VAL   B CG1 1 
ATOM   4252 C  CG2 . VAL   B 1 297 ? -32.66418 21.10659  70.46677 1.000 45.73630 ? 297 VAL   B CG2 1 
ATOM   4253 N  N   . LEU   B 1 298 ? -29.25070 20.59399  67.49838 1.000 42.91555 ? 298 LEU   B N   1 
ATOM   4254 C  CA  . LEU   B 1 298 ? -28.37282 20.58276  66.33426 1.000 44.19929 ? 298 LEU   B CA  1 
ATOM   4255 C  C   . LEU   B 1 298 ? -29.17077 20.63591  65.03207 1.000 38.05336 ? 298 LEU   B C   1 
ATOM   4256 O  O   . LEU   B 1 298 ? -30.26330 20.06881  64.93131 1.000 27.95456 ? 298 LEU   B O   1 
ATOM   4257 C  CB  . LEU   B 1 298 ? -27.50009 19.32716  66.38096 1.000 45.95986 ? 298 LEU   B CB  1 
ATOM   4258 C  CG  . LEU   B 1 298 ? -26.44487 19.03629  65.37138 1.000 41.33606 ? 298 LEU   B CG  1 
ATOM   4259 C  CD1 . LEU   B 1 298 ? -25.14959 18.96624  66.01496 1.000 42.52987 ? 298 LEU   B CD1 1 
ATOM   4260 C  CD2 . LEU   B 1 298 ? -26.73958 17.74532  64.68551 1.000 49.04167 ? 298 LEU   B CD2 1 
ATOM   4261 N  N   . LEU   B 1 299 ? -28.60738 21.30969  64.02473 1.000 38.72276 ? 299 LEU   B N   1 
ATOM   4262 C  CA  . LEU   B 1 299 ? -29.28935 21.56986  62.75680 1.000 39.92038 ? 299 LEU   B CA  1 
ATOM   4263 C  C   . LEU   B 1 299 ? -28.55071 20.87013  61.61901 1.000 31.41350 ? 299 LEU   B C   1 
ATOM   4264 O  O   . LEU   B 1 299 ? -27.45375 21.28908  61.23408 1.000 31.86924 ? 299 LEU   B O   1 
ATOM   4265 C  CB  . LEU   B 1 299 ? -29.38147 23.07280  62.49662 1.000 37.31849 ? 299 LEU   B CB  1 
ATOM   4266 C  CG  . LEU   B 1 299 ? -30.00343 23.92935  63.59945 1.000 33.45272 ? 299 LEU   B CG  1 
ATOM   4267 C  CD1 . LEU   B 1 299 ? -29.84043 25.40600  63.29056 1.000 34.59724 ? 299 LEU   B CD1 1 
ATOM   4268 C  CD2 . LEU   B 1 299 ? -31.46682 23.58081  63.76115 1.000 28.50550 ? 299 LEU   B CD2 1 
ATOM   4269 N  N   . LEU   B 1 300 ? -29.16479 19.82437  61.07062 1.000 31.03238 ? 300 LEU   B N   1 
ATOM   4270 C  CA  . LEU   B 1 300 ? -28.68173 19.14138  59.87727 1.000 32.78878 ? 300 LEU   B CA  1 
ATOM   4271 C  C   . LEU   B 1 300 ? -29.67160 19.37654  58.74549 1.000 30.10601 ? 300 LEU   B C   1 
ATOM   4272 O  O   . LEU   B 1 300 ? -30.87612 19.16976  58.92242 1.000 30.82987 ? 300 LEU   B O   1 
ATOM   4273 C  CB  . LEU   B 1 300 ? -28.52366 17.64414  60.13324 1.000 33.68036 ? 300 LEU   B CB  1 
ATOM   4274 C  CG  . LEU   B 1 300 ? -27.73358 17.25949  61.37927 1.000 34.27753 ? 300 LEU   B CG  1 
ATOM   4275 C  CD1 . LEU   B 1 300 ? -27.79646 15.76341  61.60314 1.000 37.53585 ? 300 LEU   B CD1 1 
ATOM   4276 C  CD2 . LEU   B 1 300 ? -26.29480 17.73007  61.24290 1.000 39.93906 ? 300 LEU   B CD2 1 
ATOM   4277 N  N   . ASP   B 1 301 ? -29.17267 19.80227  57.58698 1.000 33.61961 ? 301 ASP   B N   1 
ATOM   4278 C  CA  . ASP   B 1 301 ? -30.04793 20.17484  56.48348 1.000 32.18051 ? 301 ASP   B CA  1 
ATOM   4279 C  C   . ASP   B 1 301 ? -30.00897 19.20821  55.30897 1.000 31.94415 ? 301 ASP   B C   1 
ATOM   4280 O  O   . ASP   B 1 301 ? -31.06504 18.81932  54.79847 1.000 34.83047 ? 301 ASP   B O   1 
ATOM   4281 C  CB  . ASP   B 1 301 ? -29.70671 21.58253  55.99328 1.000 35.79036 ? 301 ASP   B CB  1 
ATOM   4282 C  CG  . ASP   B 1 301 ? -30.79072 22.15248  55.10296 1.000 25.84064 ? 301 ASP   B CG  1 
ATOM   4283 O  OD1 . ASP   B 1 301 ? -30.48500 22.64841  54.01225 1.000 28.13320 ? 301 ASP   B OD1 1 
ATOM   4284 O  OD2 . ASP   B 1 301 ? -31.96521 22.09953  55.48810 1.000 24.46346 ? 301 ASP   B OD2 1 
ATOM   4285 N  N   . ASN   B 1 302 ? -28.82689 18.80080  54.86173 1.000 33.89606 ? 302 ASN   B N   1 
ATOM   4286 C  CA  . ASN   B 1 302 ? -28.70973 17.93956  53.69438 1.000 38.71255 ? 302 ASN   B CA  1 
ATOM   4287 C  C   . ASN   B 1 302 ? -28.64441 16.47531  54.11009 1.000 34.25777 ? 302 ASN   B C   1 
ATOM   4288 O  O   . ASN   B 1 302 ? -28.10670 16.13434  55.16698 1.000 34.45235 ? 302 ASN   B O   1 
ATOM   4289 C  CB  . ASN   B 1 302 ? -27.47687 18.30037  52.86130 1.000 35.94710 ? 302 ASN   B CB  1 
ATOM   4290 C  CG  . ASN   B 1 302 ? -26.19133 18.23273  53.65968 1.000 42.82959 ? 302 ASN   B CG  1 
ATOM   4291 O  OD1 . ASN   B 1 302 ? -25.65124 17.15336  53.89983 1.000 44.04218 ? 302 ASN   B OD1 1 
ATOM   4292 N  ND2 . ASN   B 1 302 ? -25.68963 19.39128  54.07074 1.000 40.57957 ? 302 ASN   B ND2 1 
ATOM   4293 N  N   . TYR   B 1 303 ? -29.20412 15.61251  53.25416 1.000 32.15365 ? 303 TYR   B N   1 
ATOM   4294 C  CA  . TYR   B 1 303 ? -29.20216 14.17340  53.50791 1.000 36.77205 ? 303 TYR   B CA  1 
ATOM   4295 C  C   . TYR   B 1 303 ? -27.80715 13.66153  53.84182 1.000 28.85885 ? 303 TYR   B C   1 
ATOM   4296 O  O   . TYR   B 1 303 ? -27.65010 12.77286  54.68710 1.000 31.33713 ? 303 TYR   B O   1 
ATOM   4297 C  CB  . TYR   B 1 303 ? -29.76041 13.43215  52.28976 1.000 36.99931 ? 303 TYR   B CB  1 
ATOM   4298 C  CG  . TYR   B 1 303 ? -29.70062 11.92084  52.38771 1.000 36.63328 ? 303 TYR   B CG  1 
ATOM   4299 C  CD1 . TYR   B 1 303 ? -30.72137 11.20406  52.99789 1.000 34.33950 ? 303 TYR   B CD1 1 
ATOM   4300 C  CD2 . TYR   B 1 303 ? -28.62685 11.21076  51.86016 1.000 29.49962 ? 303 TYR   B CD2 1 
ATOM   4301 C  CE1 . TYR   B 1 303 ? -30.67281 9.82431   53.08606 1.000 32.32997 ? 303 TYR   B CE1 1 
ATOM   4302 C  CE2 . TYR   B 1 303 ? -28.56896 9.83154   51.94541 1.000 34.27454 ? 303 TYR   B CE2 1 
ATOM   4303 C  CZ  . TYR   B 1 303 ? -29.59521 9.14365   52.55859 1.000 36.74644 ? 303 TYR   B CZ  1 
ATOM   4304 O  OH  . TYR   B 1 303 ? -29.54488 7.77072   52.64539 1.000 40.91275 ? 303 TYR   B OH  1 
ATOM   4305 N  N   . SER   B 1 304 ? -26.78273 14.21564  53.18777 1.000 29.05710 ? 304 SER   B N   1 
ATOM   4306 C  CA  . SER   B 1 304 ? -25.41596 13.74043  53.38399 1.000 34.70001 ? 304 SER   B CA  1 
ATOM   4307 C  C   . SER   B 1 304 ? -25.00120 13.82977  54.84823 1.000 39.13269 ? 304 SER   B C   1 
ATOM   4308 O  O   . SER   B 1 304 ? -24.48816 12.86108  55.42022 1.000 38.51778 ? 304 SER   B O   1 
ATOM   4309 C  CB  . SER   B 1 304 ? -24.45807 14.53990  52.50009 1.000 37.82365 ? 304 SER   B CB  1 
ATOM   4310 O  OG  . SER   B 1 304 ? -23.11872 14.11884  52.68336 1.000 43.96370 ? 304 SER   B OG  1 
ATOM   4311 N  N   . ASP   B 1 305 ? -25.21769 14.98938  55.47270 1.000 32.14302 ? 305 ASP   B N   1 
ATOM   4312 C  CA  . ASP   B 1 305 ? -24.88029 15.14303  56.88434 1.000 34.50484 ? 305 ASP   B CA  1 
ATOM   4313 C  C   . ASP   B 1 305 ? -25.71901 14.21979  57.75950 1.000 34.68832 ? 305 ASP   B C   1 
ATOM   4314 O  O   . ASP   B 1 305 ? -25.20490 13.60600  58.70219 1.000 37.47671 ? 305 ASP   B O   1 
ATOM   4315 C  CB  . ASP   B 1 305 ? -25.07267 16.59824  57.31223 1.000 32.29095 ? 305 ASP   B CB  1 
ATOM   4316 C  CG  . ASP   B 1 305 ? -23.93751 17.49598  56.86246 1.000 40.95441 ? 305 ASP   B CG  1 
ATOM   4317 O  OD1 . ASP   B 1 305 ? -22.87263 16.96740  56.47893 1.000 34.82489 ? 305 ASP   B OD1 1 
ATOM   4318 O  OD2 . ASP   B 1 305 ? -24.10701 18.73308  56.90498 1.000 42.10460 ? 305 ASP   B OD2 1 
ATOM   4319 N  N   . ARG   B 1 306 ? -27.01128 14.10132  57.45195 1.000 29.95466 ? 306 ARG   B N   1 
ATOM   4320 C  CA  . ARG   B 1 306 ? -27.93283 13.37091  58.31665 1.000 30.10751 ? 306 ARG   B CA  1 
ATOM   4321 C  C   . ARG   B 1 306 ? -27.63501 11.87852  58.31892 1.000 38.79133 ? 306 ARG   B C   1 
ATOM   4322 O  O   . ARG   B 1 306 ? -27.44330 11.27764  59.38280 1.000 32.30661 ? 306 ARG   B O   1 
ATOM   4323 C  CB  . ARG   B 1 306 ? -29.36412 13.64300  57.86800 1.000 31.25364 ? 306 ARG   B CB  1 
ATOM   4324 C  CG  . ARG   B 1 306 ? -29.67536 15.10383  57.94354 1.000 36.15794 ? 306 ARG   B CG  1 
ATOM   4325 C  CD  . ARG   B 1 306 ? -30.66857 15.60438  56.91536 1.000 43.21200 ? 306 ARG   B CD  1 
ATOM   4326 N  NE  . ARG   B 1 306 ? -31.97814 14.97339  56.84994 1.000 41.62431 ? 306 ARG   B NE  1 
ATOM   4327 C  CZ  . ARG   B 1 306 ? -32.78327 14.75125  57.87924 1.000 42.88479 ? 306 ARG   B CZ  1 
ATOM   4328 N  NH1 . ARG   B 1 306 ? -32.42918 15.03096  59.12945 1.000 43.58016 ? 306 ARG   B NH1 1 
ATOM   4329 N  NH2 . ARG   B 1 306 ? -33.97121 14.22120  57.64850 1.000 41.40427 ? 306 ARG   B NH2 1 
ATOM   4330 N  N   . ILE   B 1 307 ? -27.58936 11.26175  57.13445 1.000 33.09875 ? 307 ILE   B N   1 
ATOM   4331 C  CA  . ILE   B 1 307 ? -27.26547 9.84019   57.05285 1.000 29.53121 ? 307 ILE   B CA  1 
ATOM   4332 C  C   . ILE   B 1 307 ? -25.90561 9.56761   57.68171 1.000 26.86255 ? 307 ILE   B C   1 
ATOM   4333 O  O   . ILE   B 1 307 ? -25.67065 8.48567   58.23181 1.000 30.99338 ? 307 ILE   B O   1 
ATOM   4334 C  CB  . ILE   B 1 307 ? -27.32839 9.35834   55.58753 1.000 25.79852 ? 307 ILE   B CB  1 
ATOM   4335 C  CG1 . ILE   B 1 307 ? -27.41000 7.83098   55.52520 1.000 26.22414 ? 307 ILE   B CG1 1 
ATOM   4336 C  CG2 . ILE   B 1 307 ? -26.13684 9.86906   54.78648 1.000 25.97156 ? 307 ILE   B CG2 1 
ATOM   4337 C  CD1 . ILE   B 1 307 ? -28.69202 7.27240   56.09549 1.000 22.87304 ? 307 ILE   B CD1 1 
ATOM   4338 N  N   . GLN   B 1 308 ? -25.00315 10.55057  57.64159 1.000 29.28492 ? 308 GLN   B N   1 
ATOM   4339 C  CA  . GLN   B 1 308 ? -23.70913 10.40916  58.29827 1.000 31.52892 ? 308 GLN   B CA  1 
ATOM   4340 C  C   . GLN   B 1 308 ? -23.86701 10.32727  59.81249 1.000 30.49085 ? 308 GLN   B C   1 
ATOM   4341 O  O   . GLN   B 1 308 ? -23.12402 9.59946   60.48161 1.000 27.62164 ? 308 GLN   B O   1 
ATOM   4342 C  CB  . GLN   B 1 308 ? -22.80603 11.57776  57.90171 1.000 39.90766 ? 308 GLN   B CB  1 
ATOM   4343 C  CG  . GLN   B 1 308 ? -21.48575 11.65727  58.64374 1.000 41.50776 ? 308 GLN   B CG  1 
ATOM   4344 C  CD  . GLN   B 1 308 ? -21.09896 13.07580  58.96413 1.000 54.83439 ? 308 GLN   B CD  1 
ATOM   4345 O  OE1 . GLN   B 1 308 ? -21.06095 13.46856  60.12779 1.000 52.37938 ? 308 GLN   B OE1 1 
ATOM   4346 N  NE2 . GLN   B 1 308 ? -20.80393 13.85709  57.94090 1.000 53.37457 ? 308 GLN   B NE2 1 
ATOM   4347 N  N   . VAL   B 1 309 ? -24.83269 11.06104  60.37077 1.000 28.97808 ? 309 VAL   B N   1 
ATOM   4348 C  CA  . VAL   B 1 309 ? -25.10584 10.95451  61.80086 1.000 29.19790 ? 309 VAL   B CA  1 
ATOM   4349 C  C   . VAL   B 1 309 ? -25.74247 9.60950   62.12233 1.000 31.00841 ? 309 VAL   B C   1 
ATOM   4350 O  O   . VAL   B 1 309 ? -25.40183 8.96994   63.12500 1.000 27.13241 ? 309 VAL   B O   1 
ATOM   4351 C  CB  . VAL   B 1 309 ? -25.99066 12.12334  62.27016 1.000 31.97915 ? 309 VAL   B CB  1 
ATOM   4352 C  CG1 . VAL   B 1 309 ? -26.52046 11.86418  63.67165 1.000 28.32256 ? 309 VAL   B CG1 1 
ATOM   4353 C  CG2 . VAL   B 1 309 ? -25.20555 13.40396  62.25014 1.000 33.17842 ? 309 VAL   B CG2 1 
ATOM   4354 N  N   . LEU   B 1 310 ? -26.67604 9.15812   61.28028 1.000 26.79383 ? 310 LEU   B N   1 
ATOM   4355 C  CA  . LEU   B 1 310 ? -27.32585 7.87352   61.51743 1.000 28.60623 ? 310 LEU   B CA  1 
ATOM   4356 C  C   . LEU   B 1 310 ? -26.35103 6.71283   61.37393 1.000 23.73111 ? 310 LEU   B C   1 
ATOM   4357 O  O   . LEU   B 1 310 ? -26.46862 5.71629   62.09601 1.000 27.69296 ? 310 LEU   B O   1 
ATOM   4358 C  CB  . LEU   B 1 310 ? -28.50556 7.69402   60.56373 1.000 28.85922 ? 310 LEU   B CB  1 
ATOM   4359 C  CG  . LEU   B 1 310 ? -29.74921 8.52653   60.87427 1.000 31.57477 ? 310 LEU   B CG  1 
ATOM   4360 C  CD1 . LEU   B 1 310 ? -30.85859 8.22661   59.87850 1.000 33.80842 ? 310 LEU   B CD1 1 
ATOM   4361 C  CD2 . LEU   B 1 310 ? -30.21765 8.27039   62.29782 1.000 33.21623 ? 310 LEU   B CD2 1 
ATOM   4362 N  N   . GLN   B 1 311 ? -25.39422 6.81569   60.44894 1.000 24.04305 ? 311 GLN   B N   1 
ATOM   4363 C  CA  . GLN   B 1 311 ? -24.35956 5.79268   60.33844 1.000 28.31362 ? 311 GLN   B CA  1 
ATOM   4364 C  C   . GLN   B 1 311 ? -23.51006 5.74156   61.60097 1.000 29.60865 ? 311 GLN   B C   1 
ATOM   4365 O  O   . GLN   B 1 311 ? -23.29816 4.66943   62.17855 1.000 23.40048 ? 311 GLN   B O   1 
ATOM   4366 C  CB  . GLN   B 1 311 ? -23.48365 6.05938   59.11491 1.000 25.48948 ? 311 GLN   B CB  1 
ATOM   4367 C  CG  . GLN   B 1 311 ? -24.17978 5.84487   57.78336 1.000 22.24509 ? 311 GLN   B CG  1 
ATOM   4368 C  CD  . GLN   B 1 311 ? -23.40339 6.43912   56.62717 1.000 25.82238 ? 311 GLN   B CD  1 
ATOM   4369 O  OE1 . GLN   B 1 311 ? -22.89038 7.55445   56.71951 1.000 23.56237 ? 311 GLN   B OE1 1 
ATOM   4370 N  NE2 . GLN   B 1 311 ? -23.31082 5.69666   55.53042 1.000 23.13927 ? 311 GLN   B NE2 1 
ATOM   4371 N  N   . ASN   B 1 312 ? -23.01229 6.89941   62.04407 1.000 22.79418 ? 312 ASN   B N   1 
ATOM   4372 C  CA  . ASN   B 1 312 ? -22.22235 6.94412   63.26949 1.000 27.82653 ? 312 ASN   B CA  1 
ATOM   4373 C  C   . ASN   B 1 312 ? -23.05090 6.55682   64.48700 1.000 26.78959 ? 312 ASN   B C   1 
ATOM   4374 O  O   . ASN   B 1 312 ? -22.50222 6.05329   65.47350 1.000 30.50685 ? 312 ASN   B O   1 
ATOM   4375 C  CB  . ASN   B 1 312 ? -21.61951 8.33743   63.46126 1.000 20.99455 ? 312 ASN   B CB  1 
ATOM   4376 C  CG  . ASN   B 1 312 ? -20.30878 8.51584   62.72027 1.000 26.01664 ? 312 ASN   B CG  1 
ATOM   4377 O  OD1 . ASN   B 1 312 ? -19.25784 8.06559   63.17825 1.000 27.81349 ? 312 ASN   B OD1 1 
ATOM   4378 N  ND2 . ASN   B 1 312 ? -20.36186 9.18456   61.57425 1.000 35.90319 ? 312 ASN   B ND2 1 
ATOM   4379 N  N   . MET   B 1 313 ? -24.36719 6.77593   64.43879 1.000 24.14054 ? 313 MET   B N   1 
ATOM   4380 C  CA  . MET   B 1 313 ? -25.21722 6.41875   65.57061 1.000 27.43854 ? 313 MET   B CA  1 
ATOM   4381 C  C   . MET   B 1 313 ? -25.32082 4.90722   65.72958 1.000 28.89817 ? 313 MET   B C   1 
ATOM   4382 O  O   . MET   B 1 313 ? -25.10672 4.37180   66.82273 1.000 26.94238 ? 313 MET   B O   1 
ATOM   4383 C  CB  . MET   B 1 313 ? -26.60702 7.02847   65.40577 1.000 25.07231 ? 313 MET   B CB  1 
ATOM   4384 C  CG  . MET   B 1 313 ? -27.60651 6.50535   66.42082 1.000 27.18164 ? 313 MET   B CG  1 
ATOM   4385 S  SD  . MET   B 1 313 ? -29.26125 7.15999   66.17407 1.000 33.16426 ? 313 MET   B SD  1 
ATOM   4386 C  CE  . MET   B 1 313 ? -28.93577 8.91464   66.27981 1.000 24.50072 ? 313 MET   B CE  1 
ATOM   4387 N  N   . VAL   B 1 314 ? -25.67195 4.20135   64.65336 1.000 24.33097 ? 314 VAL   B N   1 
ATOM   4388 C  CA  . VAL   B 1 314 ? -25.72737 2.74583   64.72742 1.000 22.18094 ? 314 VAL   B CA  1 
ATOM   4389 C  C   . VAL   B 1 314 ? -24.33185 2.17543   64.93490 1.000 19.15703 ? 314 VAL   B C   1 
ATOM   4390 O  O   . VAL   B 1 314 ? -24.16307 1.14617   65.60143 1.000 19.36092 ? 314 VAL   B O   1 
ATOM   4391 C  CB  . VAL   B 1 314 ? -26.40476 2.17846   63.46744 1.000 18.94950 ? 314 VAL   B CB  1 
ATOM   4392 C  CG1 . VAL   B 1 314 ? -26.44069 0.65914   63.51315 1.000 18.93690 ? 314 VAL   B CG1 1 
ATOM   4393 C  CG2 . VAL   B 1 314 ? -27.81019 2.74286   63.33893 1.000 22.47094 ? 314 VAL   B CG2 1 
ATOM   4394 N  N   . HIS   B 1 315 ? -23.31277 2.83740   64.38383 1.000 22.16021 ? 315 HIS   B N   1 
ATOM   4395 C  CA  . HIS   B 1 315 ? -21.93345 2.46645   64.67712 1.000 22.50179 ? 315 HIS   B CA  1 
ATOM   4396 C  C   . HIS   B 1 315 ? -21.64115 2.58685   66.16909 1.000 26.90770 ? 315 HIS   B C   1 
ATOM   4397 O  O   . HIS   B 1 315 ? -20.98713 1.71323   66.75235 1.000 25.08719 ? 315 HIS   B O   1 
ATOM   4398 C  CB  . HIS   B 1 315 ? -20.98787 3.34389   63.85780 1.000 17.11261 ? 315 HIS   B CB  1 
ATOM   4399 C  CG  . HIS   B 1 315 ? -19.54517 2.97533   63.98715 1.000 16.12357 ? 315 HIS   B CG  1 
ATOM   4400 N  ND1 . HIS   B 1 315 ? -19.09364 1.67753   63.87965 1.000 17.81036 ? 315 HIS   B ND1 1 
ATOM   4401 C  CD2 . HIS   B 1 315 ? -18.44829 3.74000   64.19598 1.000 16.37394 ? 315 HIS   B CD2 1 
ATOM   4402 C  CE1 . HIS   B 1 315 ? -17.78122 1.65754   64.02659 1.000 22.09694 ? 315 HIS   B CE1 1 
ATOM   4403 N  NE2 . HIS   B 1 315 ? -17.36559 2.89601   64.21966 1.000 23.52717 ? 315 HIS   B NE2 1 
ATOM   4404 N  N   . CYS   B 1 316 ? -22.11945 3.66639   66.79984 1.000 24.14435 ? 316 CYS   B N   1 
ATOM   4405 C  CA  . CYS   B 1 316 ? -22.05692 3.80070   68.25419 1.000 23.85325 ? 316 CYS   B CA  1 
ATOM   4406 C  C   . CYS   B 1 316 ? -22.67998 2.59563   68.94190 1.000 23.15909 ? 316 CYS   B C   1 
ATOM   4407 O  O   . CYS   B 1 316 ? -22.04784 1.93175   69.77047 1.000 24.76487 ? 316 CYS   B O   1 
ATOM   4408 C  CB  . CYS   B 1 316 ? -22.79006 5.06611   68.71258 1.000 26.18748 ? 316 CYS   B CB  1 
ATOM   4409 S  SG  . CYS   B 1 316 ? -21.94856 6.63946   68.56934 1.000 35.49241 ? 316 CYS   B SG  1 
ATOM   4410 N  N   . ALA   B 1 317 ? -23.94803 2.32424   68.62140 1.000 21.15515 ? 317 ALA   B N   1 
ATOM   4411 C  CA  . ALA   B 1 317 ? -24.68117 1.25361   69.28510 1.000 26.47809 ? 317 ALA   B CA  1 
ATOM   4412 C  C   . ALA   B 1 317 ? -24.03582 -0.10147  69.04132 1.000 26.15621 ? 317 ALA   B C   1 
ATOM   4413 O  O   . ALA   B 1 317 ? -24.13671 -0.99974  69.88474 1.000 28.22729 ? 317 ALA   B O   1 
ATOM   4414 C  CB  . ALA   B 1 317 ? -26.13341 1.25072   68.80983 1.000 20.20213 ? 317 ALA   B CB  1 
ATOM   4415 N  N   . ASP   B 1 318 ? -23.37279 -0.26756  67.89657 1.000 22.84925 ? 318 ASP   B N   1 
ATOM   4416 C  CA  . ASP   B 1 318 ? -22.61436 -1.48616  67.64961 1.000 19.14046 ? 318 ASP   B CA  1 
ATOM   4417 C  C   . ASP   B 1 318 ? -21.39166 -1.57004  68.55564 1.000 22.02338 ? 318 ASP   B C   1 
ATOM   4418 O  O   . ASP   B 1 318 ? -21.00680 -2.66683  68.97769 1.000 21.16902 ? 318 ASP   B O   1 
ATOM   4419 C  CB  . ASP   B 1 318 ? -22.20293 -1.54422  66.17832 1.000 21.83119 ? 318 ASP   B CB  1 
ATOM   4420 C  CG  . ASP   B 1 318 ? -21.80702 -2.93556  65.73527 1.000 21.77487 ? 318 ASP   B CG  1 
ATOM   4421 O  OD1 . ASP   B 1 318 ? -22.44823 -3.90831  66.18377 1.000 15.15509 ? 318 ASP   B OD1 1 
ATOM   4422 O  OD2 . ASP   B 1 318 ? -20.85866 -3.05382  64.93120 1.000 23.30162 ? 318 ASP   B OD2 1 
ATOM   4423 N  N   . LEU   B 1 319 ? -20.78035 -0.42919  68.87152 1.000 20.84805 ? 319 LEU   B N   1 
ATOM   4424 C  CA  . LEU   B 1 319 ? -19.60833 -0.35216  69.73774 1.000 19.58166 ? 319 LEU   B CA  1 
ATOM   4425 C  C   . LEU   B 1 319 ? -19.95989 0.24182   71.09886 1.000 19.53504 ? 319 LEU   B C   1 
ATOM   4426 O  O   . LEU   B 1 319 ? -19.22209 1.06427   71.64560 1.000 18.34965 ? 319 LEU   B O   1 
ATOM   4427 C  CB  . LEU   B 1 319 ? -18.50130 0.46417   69.07642 1.000 20.91493 ? 319 LEU   B CB  1 
ATOM   4428 C  CG  . LEU   B 1 319 ? -18.00524 -0.03605  67.71993 1.000 22.53175 ? 319 LEU   B CG  1 
ATOM   4429 C  CD1 . LEU   B 1 319 ? -16.80607 0.77674   67.25772 1.000 15.85275 ? 319 LEU   B CD1 1 
ATOM   4430 C  CD2 . LEU   B 1 319 ? -17.66437 -1.51641  67.78903 1.000 24.28504 ? 319 LEU   B CD2 1 
ATOM   4431 N  N   . SER   B 1 320 ? -21.09421 -0.16995  71.66116 1.000 18.81099 ? 320 SER   B N   1 
ATOM   4432 C  CA  . SER   B 1 320 ? -21.58864 0.39288   72.90919 1.000 23.53567 ? 320 SER   B CA  1 
ATOM   4433 C  C   . SER   B 1 320 ? -21.39826 -0.52875  74.10624 1.000 25.66103 ? 320 SER   B C   1 
ATOM   4434 O  O   . SER   B 1 320 ? -21.75321 -0.13998  75.22293 1.000 23.46972 ? 320 SER   B O   1 
ATOM   4435 C  CB  . SER   B 1 320 ? -23.07253 0.75547   72.77546 1.000 22.16958 ? 320 SER   B CB  1 
ATOM   4436 O  OG  . SER   B 1 320 ? -23.87010 -0.39974  72.58694 1.000 23.74283 ? 320 SER   B OG  1 
ATOM   4437 N  N   . ASN   B 1 321 ? -20.85705 -1.73250  73.90832 1.000 18.93794 ? 321 ASN   B N   1 
ATOM   4438 C  CA  . ASN   B 1 321 ? -20.60886 -2.63368  75.03420 1.000 20.33157 ? 321 ASN   B CA  1 
ATOM   4439 C  C   . ASN   B 1 321 ? -19.77006 -1.99875  76.13805 1.000 19.31402 ? 321 ASN   B C   1 
ATOM   4440 O  O   . ASN   B 1 321 ? -20.17381 -2.08411  77.30882 1.000 20.78400 ? 321 ASN   B O   1 
ATOM   4441 C  CB  . ASN   B 1 321 ? -19.95166 -3.93388  74.54525 1.000 19.13079 ? 321 ASN   B CB  1 
ATOM   4442 C  CG  . ASN   B 1 321 ? -20.83029 -4.71778  73.59269 1.000 23.88358 ? 321 ASN   B CG  1 
ATOM   4443 O  OD1 . ASN   B 1 321 ? -20.33688 -5.52017  72.80003 1.000 19.23654 ? 321 ASN   B OD1 1 
ATOM   4444 N  ND2 . ASN   B 1 321 ? -22.13636 -4.48865  73.66071 1.000 21.63756 ? 321 ASN   B ND2 1 
ATOM   4445 N  N   . PRO   B 1 322 ? -18.62707 -1.35716  75.86240 1.000 16.36600 ? 322 PRO   B N   1 
ATOM   4446 C  CA  . PRO   B 1 322 ? -17.84183 -0.76703  76.95743 1.000 20.16247 ? 322 PRO   B CA  1 
ATOM   4447 C  C   . PRO   B 1 322 ? -18.47794 0.45633   77.60005 1.000 28.08925 ? 322 PRO   B C   1 
ATOM   4448 O  O   . PRO   B 1 322 ? -17.91358 0.98267   78.56569 1.000 25.13834 ? 322 PRO   B O   1 
ATOM   4449 C  CB  . PRO   B 1 322 ? -16.51314 -0.39571  76.27601 1.000 21.19199 ? 322 PRO   B CB  1 
ATOM   4450 C  CG  . PRO   B 1 322 ? -16.48118 -1.19830  75.01850 1.000 20.01121 ? 322 PRO   B CG  1 
ATOM   4451 C  CD  . PRO   B 1 322 ? -17.90294 -1.25934  74.58252 1.000 20.07877 ? 322 PRO   B CD  1 
ATOM   4452 N  N   . THR   B 1 323 ? -19.61874 0.93382   77.10687 1.000 23.47841 ? 323 THR   B N   1 
ATOM   4453 C  CA  . THR   B 1 323 ? -20.30886 2.06560   77.71017 1.000 26.97633 ? 323 THR   B CA  1 
ATOM   4454 C  C   . THR   B 1 323 ? -21.48020 1.64353   78.58639 1.000 28.41834 ? 323 THR   B C   1 
ATOM   4455 O  O   . THR   B 1 323 ? -22.09652 2.49974   79.22797 1.000 27.34769 ? 323 THR   B O   1 
ATOM   4456 C  CB  . THR   B 1 323 ? -20.80583 3.02756   76.62745 1.000 22.33685 ? 323 THR   B CB  1 
ATOM   4457 O  OG1 . THR   B 1 323 ? -21.92423 2.44628   75.94667 1.000 19.66335 ? 323 THR   B OG1 1 
ATOM   4458 C  CG2 . THR   B 1 323 ? -19.70378 3.31954   75.62327 1.000 20.20496 ? 323 THR   B CG2 1 
ATOM   4459 N  N   . LYS   B 1 324 ? -21.80430 0.35894   78.62129 1.000 21.48580 ? 324 LYS   B N   1 
ATOM   4460 C  CA  . LYS   B 1 324 ? -22.87837 -0.16540  79.45268 1.000 27.75921 ? 324 LYS   B CA  1 
ATOM   4461 C  C   . LYS   B 1 324 ? -22.34774 -0.48517  80.84302 1.000 29.64979 ? 324 LYS   B C   1 
ATOM   4462 O  O   . LYS   B 1 324 ? -21.13635 -0.47801  81.07664 1.000 27.33116 ? 324 LYS   B O   1 
ATOM   4463 C  CB  . LYS   B 1 324 ? -23.47948 -1.40299  78.78643 1.000 26.68693 ? 324 LYS   B CB  1 
ATOM   4464 C  CG  . LYS   B 1 324 ? -23.92403 -1.19138  77.34213 1.000 24.24308 ? 324 LYS   B CG  1 
ATOM   4465 C  CD  . LYS   B 1 324 ? -25.10593 -0.23557  77.24314 1.000 31.38228 ? 324 LYS   B CD  1 
ATOM   4466 C  CE  . LYS   B 1 324 ? -25.63225 -0.14287  75.81496 1.000 26.85757 ? 324 LYS   B CE  1 
ATOM   4467 N  NZ  . LYS   B 1 324 ? -26.38359 -1.36415  75.40549 1.000 24.39419 ? 324 LYS   B NZ  1 
ATOM   4468 N  N   . PRO   B 1 325 ? -23.23232 -0.74332  81.81237 1.000 34.59153 ? 325 PRO   B N   1 
ATOM   4469 C  CA  . PRO   B 1 325 ? -22.75949 -1.14259  83.14509 1.000 32.05797 ? 325 PRO   B CA  1 
ATOM   4470 C  C   . PRO   B 1 325 ? -21.88444 -2.38729  83.08949 1.000 31.15958 ? 325 PRO   B C   1 
ATOM   4471 O  O   . PRO   B 1 325 ? -22.04334 -3.25022  82.22288 1.000 28.60845 ? 325 PRO   B O   1 
ATOM   4472 C  CB  . PRO   B 1 325 ? -24.05582 -1.39755  83.92836 1.000 30.26004 ? 325 PRO   B CB  1 
ATOM   4473 C  CG  . PRO   B 1 325 ? -25.16958 -1.35115  82.91178 1.000 35.37738 ? 325 PRO   B CG  1 
ATOM   4474 C  CD  . PRO   B 1 325 ? -24.67827 -0.46895  81.81540 1.000 29.08910 ? 325 PRO   B CD  1 
ATOM   4475 N  N   . LEU   B 1 326 ? -20.96271 -2.47272  84.05512 1.000 30.10915 ? 326 LEU   B N   1 
ATOM   4476 C  CA  . LEU   B 1 326 ? -19.84428 -3.40967  83.96692 1.000 29.66572 ? 326 LEU   B CA  1 
ATOM   4477 C  C   . LEU   B 1 326 ? -20.30401 -4.85438  83.80591 1.000 27.16284 ? 326 LEU   B C   1 
ATOM   4478 O  O   . LEU   B 1 326 ? -19.72348 -5.60818  83.01699 1.000 26.69188 ? 326 LEU   B O   1 
ATOM   4479 C  CB  . LEU   B 1 326 ? -18.95033 -3.26758  85.20122 1.000 28.49802 ? 326 LEU   B CB  1 
ATOM   4480 C  CG  . LEU   B 1 326 ? -17.57466 -3.93864  85.16811 1.000 25.53803 ? 326 LEU   B CG  1 
ATOM   4481 C  CD1 . LEU   B 1 326 ? -16.77581 -3.48446  83.95572 1.000 22.58776 ? 326 LEU   B CD1 1 
ATOM   4482 C  CD2 . LEU   B 1 326 ? -16.81774 -3.63932  86.45172 1.000 20.39817 ? 326 LEU   B CD2 1 
ATOM   4483 N  N   . GLN   B 1 327 ? -21.34319 -5.26384  84.53996 1.000 28.35996 ? 327 GLN   B N   1 
ATOM   4484 C  CA  . GLN   B 1 327 ? -21.77194 -6.65795  84.46104 1.000 29.83765 ? 327 GLN   B CA  1 
ATOM   4485 C  C   . GLN   B 1 327 ? -22.28393 -7.01032  83.06955 1.000 30.30122 ? 327 GLN   B C   1 
ATOM   4486 O  O   . GLN   B 1 327 ? -22.16017 -8.16157  82.63818 1.000 25.70973 ? 327 GLN   B O   1 
ATOM   4487 C  CB  . GLN   B 1 327 ? -22.83697 -6.96457  85.51796 1.000 34.20104 ? 327 GLN   B CB  1 
ATOM   4488 C  CG  . GLN   B 1 327 ? -24.14895 -6.18945  85.38426 1.000 46.13789 ? 327 GLN   B CG  1 
ATOM   4489 C  CD  . GLN   B 1 327 ? -24.16344 -4.91249  86.17957 1.000 54.70098 ? 327 GLN   B CD  1 
ATOM   4490 O  OE1 . GLN   B 1 327 ? -23.18376 -4.17304  86.22411 1.000 47.99416 ? 327 GLN   B OE1 1 
ATOM   4491 N  NE2 . GLN   B 1 327 ? -25.27981 -4.64504  86.82676 1.000 46.95746 ? 327 GLN   B NE2 1 
ATOM   4492 N  N   . LEU   B 1 328 ? -22.85616 -6.04088  82.35350 1.000 29.87411 ? 328 LEU   B N   1 
ATOM   4493 C  CA  . LEU   B 1 328 ? -23.20943 -6.26519  80.95409 1.000 25.67154 ? 328 LEU   B CA  1 
ATOM   4494 C  C   . LEU   B 1 328 ? -21.96022 -6.34467  80.08597 1.000 23.95778 ? 328 LEU   B C   1 
ATOM   4495 O  O   . LEU   B 1 328 ? -21.78770 -7.28769  79.30455 1.000 20.98389 ? 328 LEU   B O   1 
ATOM   4496 C  CB  . LEU   B 1 328 ? -24.12789 -5.14668  80.45803 1.000 25.92456 ? 328 LEU   B CB  1 
ATOM   4497 C  CG  . LEU   B 1 328 ? -25.50794 -5.04114  81.10298 1.000 32.71951 ? 328 LEU   B CG  1 
ATOM   4498 C  CD1 . LEU   B 1 328 ? -26.33698 -3.97255  80.41276 1.000 35.31680 ? 328 LEU   B CD1 1 
ATOM   4499 C  CD2 . LEU   B 1 328 ? -26.21504 -6.38032  81.05616 1.000 28.44254 ? 328 LEU   B CD2 1 
ATOM   4500 N  N   . TYR   B 1 329 ? -21.08038 -5.35039  80.22100 1.000 20.27644 ? 329 TYR   B N   1 
ATOM   4501 C  CA  . TYR   B 1 329 ? -19.86558 -5.26306  79.41669 1.000 22.65601 ? 329 TYR   B CA  1 
ATOM   4502 C  C   . TYR   B 1 329 ? -19.02132 -6.52940  79.53316 1.000 22.95581 ? 329 TYR   B C   1 
ATOM   4503 O  O   . TYR   B 1 329 ? -18.50873 -7.03618  78.52803 1.000 20.51544 ? 329 TYR   B O   1 
ATOM   4504 C  CB  . TYR   B 1 329 ? -19.09077 -4.01941  79.86436 1.000 17.68262 ? 329 TYR   B CB  1 
ATOM   4505 C  CG  . TYR   B 1 329 ? -17.75859 -3.72120  79.20687 1.000 15.98191 ? 329 TYR   B CG  1 
ATOM   4506 C  CD1 . TYR   B 1 329 ? -17.38320 -4.29994  78.00053 1.000 19.82498 ? 329 TYR   B CD1 1 
ATOM   4507 C  CD2 . TYR   B 1 329 ? -16.87494 -2.83441  79.80778 1.000 18.54811 ? 329 TYR   B CD2 1 
ATOM   4508 C  CE1 . TYR   B 1 329 ? -16.15820 -4.00937  77.42332 1.000 18.58851 ? 329 TYR   B CE1 1 
ATOM   4509 C  CE2 . TYR   B 1 329 ? -15.65829 -2.53689  79.23996 1.000 15.66115 ? 329 TYR   B CE2 1 
ATOM   4510 C  CZ  . TYR   B 1 329 ? -15.30154 -3.12597  78.04997 1.000 17.40174 ? 329 TYR   B CZ  1 
ATOM   4511 O  OH  . TYR   B 1 329 ? -14.08299 -2.82484  77.48804 1.000 15.56950 ? 329 TYR   B OH  1 
ATOM   4512 N  N   . ARG   B 1 330 ? -18.88146 -7.06737  80.74672 1.000 23.49591 ? 330 ARG   B N   1 
ATOM   4513 C  CA  . ARG   B 1 330 ? -18.01759 -8.22892  80.94108 1.000 24.48337 ? 330 ARG   B CA  1 
ATOM   4514 C  C   . ARG   B 1 330 ? -18.57325 -9.46425  80.24230 1.000 18.93918 ? 330 ARG   B C   1 
ATOM   4515 O  O   . ARG   B 1 330 ? -17.80723 -10.28907 79.73033 1.000 22.12756 ? 330 ARG   B O   1 
ATOM   4516 C  CB  . ARG   B 1 330 ? -17.82009 -8.48946  82.43341 1.000 17.83739 ? 330 ARG   B CB  1 
ATOM   4517 C  CG  . ARG   B 1 330 ? -16.95936 -7.44055  83.11721 1.000 19.19279 ? 330 ARG   B CG  1 
ATOM   4518 C  CD  . ARG   B 1 330 ? -16.91995 -7.64018  84.62082 1.000 26.05708 ? 330 ARG   B CD  1 
ATOM   4519 N  NE  . ARG   B 1 330 ? -16.19305 -8.84746  84.99986 1.000 24.66144 ? 330 ARG   B NE  1 
ATOM   4520 C  CZ  . ARG   B 1 330 ? -16.00790 -9.23854  86.25618 1.000 28.26566 ? 330 ARG   B CZ  1 
ATOM   4521 N  NH1 . ARG   B 1 330 ? -16.49758 -8.51493  87.25322 1.000 27.93871 ? 330 ARG   B NH1 1 
ATOM   4522 N  NH2 . ARG   B 1 330 ? -15.33414 -10.35048 86.51722 1.000 27.68708 ? 330 ARG   B NH2 1 
ATOM   4523 N  N   . GLN   B 1 331 ? -19.89978 -9.61235  80.20962 1.000 20.23623 ? 331 GLN   B N   1 
ATOM   4524 C  CA  . GLN   B 1 331 ? -20.49258 -10.71384 79.45761 1.000 25.18681 ? 331 GLN   B CA  1 
ATOM   4525 C  C   . GLN   B 1 331 ? -20.24481 -10.55381 77.96338 1.000 26.24052 ? 331 GLN   B C   1 
ATOM   4526 O  O   . GLN   B 1 331 ? -19.94275 -11.53290 77.27079 1.000 21.78044 ? 331 GLN   B O   1 
ATOM   4527 C  CB  . GLN   B 1 331 ? -21.99002 -10.80833 79.74693 1.000 28.76122 ? 331 GLN   B CB  1 
ATOM   4528 C  CG  . GLN   B 1 331 ? -22.32567 -11.39193 81.10854 1.000 30.60277 ? 331 GLN   B CG  1 
ATOM   4529 C  CD  . GLN   B 1 331 ? -23.80231 -11.29428 81.43120 1.000 30.75276 ? 331 GLN   B CD  1 
ATOM   4530 O  OE1 . GLN   B 1 331 ? -24.57784 -12.20288 81.13282 1.000 31.85870 ? 331 GLN   B OE1 1 
ATOM   4531 N  NE2 . GLN   B 1 331 ? -24.20034 -10.18519 82.04239 1.000 32.11298 ? 331 GLN   B NE2 1 
ATOM   4532 N  N   . TRP   B 1 332 ? -20.36783 -9.32686  77.44944 1.000 26.24855 ? 332 TRP   B N   1 
ATOM   4533 C  CA  . TRP   B 1 332 ? -20.05768 -9.08190  76.04471 1.000 22.57709 ? 332 TRP   B CA  1 
ATOM   4534 C  C   . TRP   B 1 332 ? -18.59894 -9.39825  75.74261 1.000 19.26267 ? 332 TRP   B C   1 
ATOM   4535 O  O   . TRP   B 1 332 ? -18.28495 -9.97653  74.69524 1.000 21.62067 ? 332 TRP   B O   1 
ATOM   4536 C  CB  . TRP   B 1 332 ? -20.37639 -7.63205  75.67344 1.000 23.09114 ? 332 TRP   B CB  1 
ATOM   4537 C  CG  . TRP   B 1 332 ? -21.84327 -7.31902  75.60108 1.000 17.95359 ? 332 TRP   B CG  1 
ATOM   4538 C  CD1 . TRP   B 1 332 ? -22.50675 -6.33873  76.28139 1.000 21.48600 ? 332 TRP   B CD1 1 
ATOM   4539 C  CD2 . TRP   B 1 332 ? -22.82744 -7.98783  74.80177 1.000 18.46481 ? 332 TRP   B CD2 1 
ATOM   4540 N  NE1 . TRP   B 1 332 ? -23.84136 -6.35542  75.95489 1.000 20.48627 ? 332 TRP   B NE1 1 
ATOM   4541 C  CE2 . TRP   B 1 332 ? -24.06410 -7.35932  75.04954 1.000 20.24144 ? 332 TRP   B CE2 1 
ATOM   4542 C  CE3 . TRP   B 1 332 ? -22.78318 -9.05719  73.90123 1.000 20.65343 ? 332 TRP   B CE3 1 
ATOM   4543 C  CZ2 . TRP   B 1 332 ? -25.24440 -7.76468  74.43014 1.000 20.99157 ? 332 TRP   B CZ2 1 
ATOM   4544 C  CZ3 . TRP   B 1 332 ? -23.95535 -9.45806  73.28849 1.000 16.26791 ? 332 TRP   B CZ3 1 
ATOM   4545 C  CH2 . TRP   B 1 332 ? -25.16911 -8.81370  73.55546 1.000 20.40593 ? 332 TRP   B CH2 1 
ATOM   4546 N  N   . THR   B 1 333 ? -17.69325 -9.02710  76.65209 1.000 21.33068 ? 333 THR   B N   1 
ATOM   4547 C  CA  . THR   B 1 333 ? -16.27802 -9.32786  76.45906 1.000 16.99329 ? 333 THR   B CA  1 
ATOM   4548 C  C   . THR   B 1 333 ? -16.03357 -10.83120 76.42060 1.000 19.81049 ? 333 THR   B C   1 
ATOM   4549 O  O   . THR   B 1 333 ? -15.29274 -11.32379 75.56123 1.000 19.35253 ? 333 THR   B O   1 
ATOM   4550 C  CB  . THR   B 1 333 ? -15.44672 -8.67669  77.56473 1.000 18.41442 ? 333 THR   B CB  1 
ATOM   4551 O  OG1 . THR   B 1 333 ? -15.53592 -7.25102  77.45386 1.000 22.52046 ? 333 THR   B OG1 1 
ATOM   4552 C  CG2 . THR   B 1 333 ? -13.98836 -9.09545  77.45709 1.000 16.96599 ? 333 THR   B CG2 1 
ATOM   4553 N  N   . ASP   B 1 334 ? -16.64871 -11.57640 77.34449 1.000 21.33761 ? 334 ASP   B N   1 
ATOM   4554 C  CA  . ASP   B 1 334 ? -16.54130 -13.03255 77.31657 1.000 24.01772 ? 334 ASP   B CA  1 
ATOM   4555 C  C   . ASP   B 1 334 ? -16.99372 -13.59296 75.97514 1.000 24.27186 ? 334 ASP   B C   1 
ATOM   4556 O  O   . ASP   B 1 334 ? -16.37014 -14.51393 75.43431 1.000 21.65500 ? 334 ASP   B O   1 
ATOM   4557 C  CB  . ASP   B 1 334 ? -17.37038 -13.64907 78.44524 1.000 23.22219 ? 334 ASP   B CB  1 
ATOM   4558 C  CG  . ASP   B 1 334 ? -16.72670 -13.48301 79.80670 1.000 31.74364 ? 334 ASP   B CG  1 
ATOM   4559 O  OD1 . ASP   B 1 334 ? -15.52165 -13.16024 79.86288 1.000 30.61691 ? 334 ASP   B OD1 1 
ATOM   4560 O  OD2 . ASP   B 1 334 ? -17.42759 -13.68369 80.82196 1.000 34.04357 ? 334 ASP   B OD2 1 
ATOM   4561 N  N   . ARG   B 1 335 ? -18.07161 -13.03968 75.41689 1.000 19.23580 ? 335 ARG   B N   1 
ATOM   4562 C  CA  . ARG   B 1 335 ? -18.65088 -13.61053 74.20634 1.000 18.81003 ? 335 ARG   B CA  1 
ATOM   4563 C  C   . ARG   B 1 335 ? -17.81138 -13.29253 72.97485 1.000 20.07931 ? 335 ARG   B C   1 
ATOM   4564 O  O   . ARG   B 1 335 ? -17.61143 -14.16081 72.11717 1.000 17.86839 ? 335 ARG   B O   1 
ATOM   4565 C  CB  . ARG   B 1 335 ? -20.08639 -13.11585 74.03670 1.000 20.60812 ? 335 ARG   B CB  1 
ATOM   4566 C  CG  . ARG   B 1 335 ? -21.05111 -13.74972 75.02646 1.000 23.72050 ? 335 ARG   B CG  1 
ATOM   4567 C  CD  . ARG   B 1 335 ? -22.41450 -13.08552 75.01055 1.000 21.83218 ? 335 ARG   B CD  1 
ATOM   4568 N  NE  . ARG   B 1 335 ? -23.36523 -13.81343 75.84500 1.000 24.68790 ? 335 ARG   B NE  1 
ATOM   4569 C  CZ  . ARG   B 1 335 ? -24.20155 -14.73848 75.38667 1.000 26.27010 ? 335 ARG   B CZ  1 
ATOM   4570 N  NH1 . ARG   B 1 335 ? -24.21054 -15.04370 74.09635 1.000 24.66563 ? 335 ARG   B NH1 1 
ATOM   4571 N  NH2 . ARG   B 1 335 ? -25.03154 -15.35611 76.21618 1.000 32.94416 ? 335 ARG   B NH2 1 
ATOM   4572 N  N   . ILE   B 1 336 ? -17.30783 -12.06075 72.86377 1.000 16.39351 ? 336 ILE   B N   1 
ATOM   4573 C  CA  . ILE   B 1 336 ? -16.49551 -11.73121 71.69690 1.000 19.45599 ? 336 ILE   B CA  1 
ATOM   4574 C  C   . ILE   B 1 336 ? -15.15390 -12.45322 71.75461 1.000 17.83140 ? 336 ILE   B C   1 
ATOM   4575 O  O   . ILE   B 1 336 ? -14.60463 -12.83455 70.71401 1.000 18.30726 ? 336 ILE   B O   1 
ATOM   4576 C  CB  . ILE   B 1 336 ? -16.31917 -10.20547 71.55791 1.000 17.39036 ? 336 ILE   B CB  1 
ATOM   4577 C  CG1 . ILE   B 1 336 ? -15.78090 -9.85660  70.16840 1.000 20.36131 ? 336 ILE   B CG1 1 
ATOM   4578 C  CG2 . ILE   B 1 336 ? -15.39085 -9.65539  72.62956 1.000 16.95140 ? 336 ILE   B CG2 1 
ATOM   4579 C  CD1 . ILE   B 1 336 ? -16.78928 -10.05134 69.05532 1.000 18.68635 ? 336 ILE   B CD1 1 
ATOM   4580 N  N   . MET   B 1 337 ? -14.61088 -12.67335 72.95637 1.000 19.24461 ? 337 MET   B N   1 
ATOM   4581 C  CA  . MET   B 1 337 ? -13.34888 -13.39879 73.06461 1.000 20.64694 ? 337 MET   B CA  1 
ATOM   4582 C  C   . MET   B 1 337 ? -13.53634 -14.87361 72.73887 1.000 20.72323 ? 337 MET   B C   1 
ATOM   4583 O  O   . MET   B 1 337 ? -12.65278 -15.50221 72.14526 1.000 21.78197 ? 337 MET   B O   1 
ATOM   4584 C  CB  . MET   B 1 337 ? -12.75134 -13.22799 74.46158 1.000 22.57507 ? 337 MET   B CB  1 
ATOM   4585 C  CG  . MET   B 1 337 ? -12.25864 -11.81953 74.75936 1.000 27.03802 ? 337 MET   B CG  1 
ATOM   4586 S  SD  . MET   B 1 337 ? -11.29007 -11.09655 73.41771 1.000 24.17673 ? 337 MET   B SD  1 
ATOM   4587 C  CE  . MET   B 1 337 ? -9.92169  -12.24602 73.30765 1.000 26.04535 ? 337 MET   B CE  1 
ATOM   4588 N  N   . GLU   B 1 338 ? -14.67931 -15.44245 73.12339 1.000 18.06451 ? 338 GLU   B N   1 
ATOM   4589 C  CA  . GLU   B 1 338 ? -14.99392 -16.80984 72.72758 1.000 25.18189 ? 338 GLU   B CA  1 
ATOM   4590 C  C   . GLU   B 1 338 ? -15.08373 -16.92565 71.21111 1.000 26.64389 ? 338 GLU   B C   1 
ATOM   4591 O  O   . GLU   B 1 338 ? -14.63845 -17.91993 70.62563 1.000 23.78984 ? 338 GLU   B O   1 
ATOM   4592 C  CB  . GLU   B 1 338 ? -16.29956 -17.24508 73.39687 1.000 23.10229 ? 338 GLU   B CB  1 
ATOM   4593 C  CG  . GLU   B 1 338 ? -16.72726 -18.68461 73.14901 1.000 40.57226 ? 338 GLU   B CG  1 
ATOM   4594 C  CD  . GLU   B 1 338 ? -17.94421 -19.05789 73.96099 1.000 49.58991 ? 338 GLU   B CD  1 
ATOM   4595 O  OE1 . GLU   B 1 338 ? -18.00143 -18.65068 75.14055 1.000 55.81427 ? 338 GLU   B OE1 1 
ATOM   4596 O  OE2 . GLU   B 1 338 ? -18.83566 -19.74952 73.42013 1.000 48.36880 ? 338 GLU   B OE2 1 
ATOM   4597 N  N   . GLU   B 1 339 ? -15.64109 -15.90474 70.55734 1.000 23.17050 ? 339 GLU   B N   1 
ATOM   4598 C  CA  . GLU   B 1 339 ? -15.73939 -15.91547 69.10252 1.000 25.29266 ? 339 GLU   B CA  1 
ATOM   4599 C  C   . GLU   B 1 339 ? -14.37252 -15.72894 68.45515 1.000 24.50364 ? 339 GLU   B C   1 
ATOM   4600 O  O   . GLU   B 1 339 ? -14.04876 -16.40571 67.47212 1.000 26.57275 ? 339 GLU   B O   1 
ATOM   4601 C  CB  . GLU   B 1 339 ? -16.70728 -14.82719 68.64434 1.000 19.24566 ? 339 GLU   B CB  1 
ATOM   4602 C  CG  . GLU   B 1 339 ? -17.50568 -15.17527 67.40693 1.000 22.58186 ? 339 GLU   B CG  1 
ATOM   4603 C  CD  . GLU   B 1 339 ? -18.50690 -14.09655 67.05433 1.000 15.40119 ? 339 GLU   B CD  1 
ATOM   4604 O  OE1 . GLU   B 1 339 ? -19.54115 -14.00514 67.74213 1.000 19.68316 ? 339 GLU   B OE1 1 
ATOM   4605 O  OE2 . GLU   B 1 339 ? -18.25905 -13.33704 66.09581 1.000 17.58309 ? 339 GLU   B OE2 1 
ATOM   4606 N  N   . PHE   B 1 340 ? -13.55985 -14.81283 68.98931 1.000 19.32200 ? 340 PHE   B N   1 
ATOM   4607 C  CA  . PHE   B 1 340 ? -12.21101 -14.61552 68.46510 1.000 25.51762 ? 340 PHE   B CA  1 
ATOM   4608 C  C   . PHE   B 1 340 ? -11.37973 -15.88371 68.60220 1.000 29.22297 ? 340 PHE   B C   1 
ATOM   4609 O  O   . PHE   B 1 340 ? -10.69741 -16.30019 67.65869 1.000 29.99564 ? 340 PHE   B O   1 
ATOM   4610 C  CB  . PHE   B 1 340 ? -11.52191 -13.45798 69.18993 1.000 24.12666 ? 340 PHE   B CB  1 
ATOM   4611 C  CG  . PHE   B 1 340 ? -11.89266 -12.09887 68.67157 1.000 30.76103 ? 340 PHE   B CG  1 
ATOM   4612 C  CD1 . PHE   B 1 340 ? -13.05305 -11.90398 67.94142 1.000 30.10826 ? 340 PHE   B CD1 1 
ATOM   4613 C  CD2 . PHE   B 1 340 ? -11.06672 -11.01308 68.91016 1.000 30.82006 ? 340 PHE   B CD2 1 
ATOM   4614 C  CE1 . PHE   B 1 340 ? -13.38574 -10.65002 67.46811 1.000 31.00677 ? 340 PHE   B CE1 1 
ATOM   4615 C  CE2 . PHE   B 1 340 ? -11.39276 -9.75918  68.43860 1.000 30.22013 ? 340 PHE   B CE2 1 
ATOM   4616 C  CZ  . PHE   B 1 340 ? -12.55265 -9.57779  67.71669 1.000 25.05706 ? 340 PHE   B CZ  1 
ATOM   4617 N  N   . PHE   B 1 341 ? -11.41988 -16.50750 69.78173 1.000 26.23896 ? 341 PHE   B N   1 
ATOM   4618 C  CA  . PHE   B 1 341 ? -10.61672 -17.70265 70.01579 1.000 30.21925 ? 341 PHE   B CA  1 
ATOM   4619 C  C   . PHE   B 1 341 ? -11.05128 -18.84628 69.11157 1.000 30.31298 ? 341 PHE   B C   1 
ATOM   4620 O  O   . PHE   B 1 341 ? -10.21305 -19.59560 68.59774 1.000 31.58378 ? 341 PHE   B O   1 
ATOM   4621 C  CB  . PHE   B 1 341 ? -10.70592 -18.11364 71.48458 1.000 26.86319 ? 341 PHE   B CB  1 
ATOM   4622 C  CG  . PHE   B 1 341 ? -10.01579 -17.16444 72.41921 1.000 29.70314 ? 341 PHE   B CG  1 
ATOM   4623 C  CD1 . PHE   B 1 341 ? -9.05204  -16.28910 71.94819 1.000 27.95509 ? 341 PHE   B CD1 1 
ATOM   4624 C  CD2 . PHE   B 1 341 ? -10.32671 -17.15014 73.76822 1.000 24.77556 ? 341 PHE   B CD2 1 
ATOM   4625 C  CE1 . PHE   B 1 341 ? -8.41408  -15.41733 72.80296 1.000 24.17002 ? 341 PHE   B CE1 1 
ATOM   4626 C  CE2 . PHE   B 1 341 ? -9.69025  -16.27966 74.62957 1.000 27.17707 ? 341 PHE   B CE2 1 
ATOM   4627 C  CZ  . PHE   B 1 341 ? -8.73205  -15.41307 74.14648 1.000 26.78651 ? 341 PHE   B CZ  1 
ATOM   4628 N  N   . ARG   B 1 342 ? -12.35716 -18.99194 68.89545 1.000 33.05933 ? 342 ARG   B N   1 
ATOM   4629 C  CA  . ARG   B 1 342 ? -12.82612 -20.05568 68.02039 1.000 32.49582 ? 342 ARG   B CA  1 
ATOM   4630 C  C   . ARG   B 1 342 ? -12.44601 -19.79991 66.56987 1.000 36.72995 ? 342 ARG   B C   1 
ATOM   4631 O  O   . ARG   B 1 342 ? -12.25704 -20.75091 65.80455 1.000 36.95805 ? 342 ARG   B O   1 
ATOM   4632 C  CB  . ARG   B 1 342 ? -14.33089 -20.21813 68.15673 1.000 31.69121 ? 342 ARG   B CB  1 
ATOM   4633 C  CG  . ARG   B 1 342 ? -14.74372 -20.95664 69.39935 1.000 41.36415 ? 342 ARG   B CG  1 
ATOM   4634 C  CD  . ARG   B 1 342 ? -16.20596 -21.35552 69.29298 1.000 49.91616 ? 342 ARG   B CD  1 
ATOM   4635 N  NE  . ARG   B 1 342 ? -16.99494 -20.94011 70.43606 1.000 57.08945 ? 342 ARG   B NE  1 
ATOM   4636 C  CZ  . ARG   B 1 342 ? -18.30841 -21.08337 70.49293 1.000 64.14675 ? 342 ARG   B CZ  1 
ATOM   4637 N  NH1 . ARG   B 1 342 ? -18.95257 -21.61681 69.46540 1.000 65.34109 ? 342 ARG   B NH1 1 
ATOM   4638 N  NH2 . ARG   B 1 342 ? -18.99271 -20.69615 71.55648 1.000 67.07838 ? 342 ARG   B NH2 1 
ATOM   4639 N  N   . GLN   B 1 343 ? -12.32167 -18.53326 66.17059 1.000 31.29552 ? 343 GLN   B N   1 
ATOM   4640 C  CA  . GLN   B 1 343 ? -11.79126 -18.25233 64.84137 1.000 31.45078 ? 343 GLN   B CA  1 
ATOM   4641 C  C   . GLN   B 1 343 ? -10.29914 -18.54881 64.77662 1.000 34.83220 ? 343 GLN   B C   1 
ATOM   4642 O  O   . GLN   B 1 343 ? -9.82325  -19.15631 63.81066 1.000 33.31128 ? 343 GLN   B O   1 
ATOM   4643 C  CB  . GLN   B 1 343 ? -12.06087 -16.80256 64.44342 1.000 25.43788 ? 343 GLN   B CB  1 
ATOM   4644 C  CG  . GLN   B 1 343 ? -11.42249 -16.44154 63.11052 1.000 24.13000 ? 343 GLN   B CG  1 
ATOM   4645 C  CD  . GLN   B 1 343 ? -11.67311 -15.00795 62.69529 1.000 25.88463 ? 343 GLN   B CD  1 
ATOM   4646 O  OE1 . GLN   B 1 343 ? -12.77955 -14.49058 62.83836 1.000 21.41244 ? 343 GLN   B OE1 1 
ATOM   4647 N  NE2 . GLN   B 1 343 ? -10.64155 -14.35790 62.17103 1.000 18.41034 ? 343 GLN   B NE2 1 
ATOM   4648 N  N   . GLY   B 1 344 ? -9.54481  -18.12425 65.79396 1.000 30.56091 ? 344 GLY   B N   1 
ATOM   4649 C  CA  . GLY   B 1 344 ? -8.13280  -18.45932 65.84493 1.000 34.68193 ? 344 GLY   B CA  1 
ATOM   4650 C  C   . GLY   B 1 344 ? -7.88094  -19.95349 65.83997 1.000 38.33886 ? 344 GLY   B C   1 
ATOM   4651 O  O   . GLY   B 1 344 ? -6.86984  -20.41426 65.30503 1.000 38.55302 ? 344 GLY   B O   1 
ATOM   4652 N  N   . ASP   B 1 345 ? -8.79631  -20.73165 66.42427 1.000 43.50693 ? 345 ASP   B N   1 
ATOM   4653 C  CA  . ASP   B 1 345 ? -8.65718  -22.18377 66.39445 1.000 40.79141 ? 345 ASP   B CA  1 
ATOM   4654 C  C   . ASP   B 1 345 ? -8.88606  -22.74099 64.99620 1.000 47.30944 ? 345 ASP   B C   1 
ATOM   4655 O  O   . ASP   B 1 345 ? -8.25084  -23.73025 64.61374 1.000 50.64746 ? 345 ASP   B O   1 
ATOM   4656 C  CB  . ASP   B 1 345 ? -9.62247  -22.82770 67.38883 1.000 38.60629 ? 345 ASP   B CB  1 
ATOM   4657 C  CG  . ASP   B 1 345 ? -9.20586  -22.60690 68.82843 1.000 34.01967 ? 345 ASP   B CG  1 
ATOM   4658 O  OD1 . ASP   B 1 345 ? -8.11983  -22.03123 69.05127 1.000 34.60828 ? 345 ASP   B OD1 1 
ATOM   4659 O  OD2 . ASP   B 1 345 ? -9.95942  -23.01486 69.73617 1.000 33.64791 ? 345 ASP   B OD2 1 
ATOM   4660 N  N   . ARG   B 1 346 ? -9.78771  -22.13097 64.22458 1.000 43.85782 ? 346 ARG   B N   1 
ATOM   4661 C  CA  . ARG   B 1 346 ? -9.95229  -22.53926 62.83473 1.000 47.60859 ? 346 ARG   B CA  1 
ATOM   4662 C  C   . ARG   B 1 346 ? -8.77287  -22.07391 61.99167 1.000 42.99089 ? 346 ARG   B C   1 
ATOM   4663 O  O   . ARG   B 1 346 ? -8.33873  -22.78143 61.07653 1.000 49.65621 ? 346 ARG   B O   1 
ATOM   4664 C  CB  . ARG   B 1 346 ? -11.27001 -21.99830 62.28271 1.000 39.59013 ? 346 ARG   B CB  1 
ATOM   4665 C  CG  . ARG   B 1 346 ? -12.48980 -22.47934 63.05065 1.000 42.47908 ? 346 ARG   B CG  1 
ATOM   4666 C  CD  . ARG   B 1 346 ? -13.64433 -21.50040 62.92400 1.000 44.95348 ? 346 ARG   B CD  1 
ATOM   4667 N  NE  . ARG   B 1 346 ? -14.26992 -21.54742 61.60729 1.000 51.46403 ? 346 ARG   B NE  1 
ATOM   4668 C  CZ  . ARG   B 1 346 ? -15.42945 -22.14565 61.35909 1.000 55.25558 ? 346 ARG   B CZ  1 
ATOM   4669 N  NH1 . ARG   B 1 346 ? -16.08692 -22.74462 62.34172 1.000 54.28457 ? 346 ARG   B NH1 1 
ATOM   4670 N  NH2 . ARG   B 1 346 ? -15.93445 -22.14569 60.13338 1.000 57.06600 ? 346 ARG   B NH2 1 
ATOM   4671 N  N   . GLU   B 1 347 ? -8.23131  -20.89204 62.29511 1.000 34.95456 ? 347 GLU   B N   1 
ATOM   4672 C  CA  . GLU   B 1 347 ? -7.00821  -20.45237 61.63432 1.000 42.18062 ? 347 GLU   B CA  1 
ATOM   4673 C  C   . GLU   B 1 347 ? -5.84099  -21.37432 61.96245 1.000 53.84481 ? 347 GLU   B C   1 
ATOM   4674 O  O   . GLU   B 1 347 ? -4.96117  -21.58766 61.12014 1.000 54.12948 ? 347 GLU   B O   1 
ATOM   4675 C  CB  . GLU   B 1 347 ? -6.69195  -19.01003 62.03335 1.000 40.29153 ? 347 GLU   B CB  1 
ATOM   4676 C  CG  . GLU   B 1 347 ? -7.75894  -18.01499 61.59644 1.000 43.24409 ? 347 GLU   B CG  1 
ATOM   4677 C  CD  . GLU   B 1 347 ? -7.52140  -16.61589 62.12940 1.000 40.98394 ? 347 GLU   B CD  1 
ATOM   4678 O  OE1 . GLU   B 1 347 ? -6.81249  -16.47537 63.14692 1.000 40.88467 ? 347 GLU   B OE1 1 
ATOM   4679 O  OE2 . GLU   B 1 347 ? -8.04696  -15.65474 61.52962 1.000 29.97993 ? 347 GLU   B OE2 1 
ATOM   4680 N  N   . ARG   B 1 348 ? -5.82670  -21.94563 63.16864 1.000 50.65413 ? 348 ARG   B N   1 
ATOM   4681 C  CA  . ARG   B 1 348 ? -4.76001  -22.86548 63.54769 1.000 54.47196 ? 348 ARG   B CA  1 
ATOM   4682 C  C   . ARG   B 1 348 ? -4.94664  -24.23318 62.89647 1.000 53.00633 ? 348 ARG   B C   1 
ATOM   4683 O  O   . ARG   B 1 348 ? -4.00721  -24.77571 62.30392 1.000 54.47436 ? 348 ARG   B O   1 
ATOM   4684 C  CB  . ARG   B 1 348 ? -4.69316  -22.99366 65.07230 1.000 50.46336 ? 348 ARG   B CB  1 
ATOM   4685 C  CG  . ARG   B 1 348 ? -3.38755  -23.58244 65.58889 1.000 53.18274 ? 348 ARG   B CG  1 
ATOM   4686 C  CD  . ARG   B 1 348 ? -3.33362  -23.60383 67.11151 1.000 47.71494 ? 348 ARG   B CD  1 
ATOM   4687 N  NE  . ARG   B 1 348 ? -3.26591  -22.26385 67.69047 1.000 55.14313 ? 348 ARG   B NE  1 
ATOM   4688 C  CZ  . ARG   B 1 348 ? -4.27484  -21.66973 68.32005 1.000 49.52140 ? 348 ARG   B CZ  1 
ATOM   4689 N  NH1 . ARG   B 1 348 ? -5.43341  -22.29895 68.45814 1.000 42.49486 ? 348 ARG   B NH1 1 
ATOM   4690 N  NH2 . ARG   B 1 348 ? -4.12484  -20.44950 68.81735 1.000 46.40991 ? 348 ARG   B NH2 1 
ATOM   4691 N  N   . GLU   B 1 349 ? -6.15467  -24.80289 62.99010 1.000 50.98759 ? 349 GLU   B N   1 
ATOM   4692 C  CA  . GLU   B 1 349 ? -6.39960  -26.12057 62.40671 1.000 53.87667 ? 349 GLU   B CA  1 
ATOM   4693 C  C   . GLU   B 1 349 ? -6.17002  -26.10742 60.89830 1.000 57.24911 ? 349 GLU   B C   1 
ATOM   4694 O  O   . GLU   B 1 349 ? -5.54738  -27.02500 60.34953 1.000 56.12748 ? 349 GLU   B O   1 
ATOM   4695 C  CB  . GLU   B 1 349 ? -7.81877  -26.59743 62.74583 1.000 60.62330 ? 349 GLU   B CB  1 
ATOM   4696 C  CG  . GLU   B 1 349 ? -8.91353  -26.12656 61.78955 1.000 69.41083 ? 349 GLU   B CG  1 
ATOM   4697 C  CD  . GLU   B 1 349 ? -10.28917 -26.64280 62.14511 1.000 81.42317 ? 349 GLU   B CD  1 
ATOM   4698 O  OE1 . GLU   B 1 349 ? -11.19704 -26.53260 61.29453 1.000 83.94457 ? 349 GLU   B OE1 1 
ATOM   4699 O  OE2 . GLU   B 1 349 ? -10.46402 -27.15005 63.27143 1.000 78.96250 ? 349 GLU   B OE2 1 
ATOM   4700 N  N   . ARG   B 1 350 ? -6.64135  -25.06290 60.21493 1.000 55.76690 ? 350 ARG   B N   1 
ATOM   4701 C  CA  . ARG   B 1 350 ? -6.40270  -24.90770 58.78916 1.000 55.72628 ? 350 ARG   B CA  1 
ATOM   4702 C  C   . ARG   B 1 350 ? -4.98483  -24.45750 58.49381 1.000 50.65353 ? 350 ARG   B C   1 
ATOM   4703 O  O   . ARG   B 1 350 ? -4.59985  -24.39571 57.32196 1.000 53.00633 ? 350 ARG   B O   1 
ATOM   4704 C  CB  . ARG   B 1 350 ? -7.37764  -23.89676 58.18986 1.000 52.64727 ? 350 ARG   B CB  1 
ATOM   4705 C  CG  . ARG   B 1 350 ? -8.84232  -24.23022 58.36339 1.000 53.13262 ? 350 ARG   B CG  1 
ATOM   4706 C  CD  . ARG   B 1 350 ? -9.65373  -23.05979 57.86710 1.000 54.53567 ? 350 ARG   B CD  1 
ATOM   4707 N  NE  . ARG   B 1 350 ? -9.01710  -22.48639 56.68675 1.000 55.81491 ? 350 ARG   B NE  1 
ATOM   4708 C  CZ  . ARG   B 1 350 ? -9.48213  -22.60915 55.45038 1.000 54.52571 ? 350 ARG   B CZ  1 
ATOM   4709 N  NH1 . ARG   B 1 350 ? -10.60632 -23.27394 55.23012 1.000 54.02069 ? 350 ARG   B NH1 1 
ATOM   4710 N  NH2 . ARG   B 1 350 ? -8.82812  -22.05813 54.43643 1.000 44.81457 ? 350 ARG   B NH2 1 
ATOM   4711 N  N   . GLY   B 1 351 ? -4.21614  -24.12897 59.52269 1.000 49.55471 ? 351 GLY   B N   1 
ATOM   4712 C  CA  . GLY   B 1 351 ? -2.84610  -23.73068 59.33333 1.000 48.64023 ? 351 GLY   B CA  1 
ATOM   4713 C  C   . GLY   B 1 351 ? -2.66471  -22.41386 58.61526 1.000 45.72927 ? 351 GLY   B C   1 
ATOM   4714 O  O   . GLY   B 1 351 ? -1.89204  -22.32401 57.65685 1.000 49.06529 ? 351 GLY   B O   1 
ATOM   4715 N  N   . MET   B 1 352 ? -3.37225  -21.38277 59.05555 1.000 49.90229 ? 352 MET   B N   1 
ATOM   4716 C  CA  . MET   B 1 352 ? -3.04017  -20.03499 58.64146 1.000 51.39799 ? 352 MET   B CA  1 
ATOM   4717 C  C   . MET   B 1 352 ? -2.76792  -19.17983 59.86639 1.000 54.85916 ? 352 MET   B C   1 
ATOM   4718 O  O   . MET   B 1 352 ? -3.05583  -19.56124 61.00489 1.000 51.06687 ? 352 MET   B O   1 
ATOM   4719 C  CB  . MET   B 1 352 ? -4.13572  -19.39377 57.78935 1.000 51.67105 ? 352 MET   B CB  1 
ATOM   4720 C  CG  . MET   B 1 352 ? -5.52365  -19.71634 58.23353 1.000 52.89279 ? 352 MET   B CG  1 
ATOM   4721 S  SD  . MET   B 1 352 ? -6.72601  -18.92640 57.16603 1.000 46.56434 ? 352 MET   B SD  1 
ATOM   4722 C  CE  . MET   B 1 352 ? -8.19233  -19.67557 57.82308 1.000 37.26840 ? 352 MET   B CE  1 
ATOM   4723 N  N   . GLU   B 1 353 ? -2.18052  -18.02095 59.59402 1.000 47.62100 ? 353 GLU   B N   1 
ATOM   4724 C  CA  . GLU   B 1 353 ? -1.84340  -17.03970 60.60987 1.000 53.60496 ? 353 GLU   B CA  1 
ATOM   4725 C  C   . GLU   B 1 353 ? -3.00427  -16.80037 61.56588 1.000 55.44467 ? 353 GLU   B C   1 
ATOM   4726 O  O   . GLU   B 1 353 ? -4.16794  -16.76561 61.15850 1.000 49.94796 ? 353 GLU   B O   1 
ATOM   4727 C  CB  . GLU   B 1 353 ? -1.43488  -15.74634 59.90338 1.000 48.77065 ? 353 GLU   B CB  1 
ATOM   4728 C  CG  . GLU   B 1 353 ? -1.63116  -14.47597 60.68014 1.000 51.73849 ? 353 GLU   B CG  1 
ATOM   4729 C  CD  . GLU   B 1 353 ? -0.73592  -13.37193 60.16302 1.000 56.23988 ? 353 GLU   B CD  1 
ATOM   4730 O  OE1 . GLU   B 1 353 ? 0.49819   -13.55939 60.17347 1.000 59.76007 ? 353 GLU   B OE1 1 
ATOM   4731 O  OE2 . GLU   B 1 353 ? -1.26221  -12.33073 59.72310 1.000 67.77022 ? 353 GLU   B OE2 1 
ATOM   4732 N  N   . ILE   B 1 354 ? -2.67992  -16.66948 62.84875 1.000 55.50631 ? 354 ILE   B N   1 
ATOM   4733 C  CA  . ILE   B 1 354 ? -3.68485  -16.35975 63.85829 1.000 48.73232 ? 354 ILE   B CA  1 
ATOM   4734 C  C   . ILE   B 1 354 ? -3.92116  -14.85600 63.84531 1.000 48.18521 ? 354 ILE   B C   1 
ATOM   4735 O  O   . ILE   B 1 354 ? -2.99283  -14.07029 64.06298 1.000 54.59287 ? 354 ILE   B O   1 
ATOM   4736 C  CB  . ILE   B 1 354 ? -3.24825  -16.84073 65.24893 1.000 46.39801 ? 354 ILE   B CB  1 
ATOM   4737 C  CG1 . ILE   B 1 354 ? -2.77428  -18.29471 65.19255 1.000 48.00107 ? 354 ILE   B CG1 1 
ATOM   4738 C  CG2 . ILE   B 1 354 ? -4.39679  -16.69499 66.24360 1.000 42.04301 ? 354 ILE   B CG2 1 
ATOM   4739 C  CD1 . ILE   B 1 354 ? -3.88516  -19.29287 64.98296 1.000 47.93579 ? 354 ILE   B CD1 1 
ATOM   4740 N  N   . SER   B 1 355 ? -5.16138  -14.45373 63.57897 1.000 44.65331 ? 355 SER   B N   1 
ATOM   4741 C  CA  . SER   B 1 355 ? -5.48959  -13.03877 63.53508 1.000 43.91491 ? 355 SER   B CA  1 
ATOM   4742 C  C   . SER   B 1 355 ? -5.23898  -12.39924 64.89985 1.000 50.26338 ? 355 SER   B C   1 
ATOM   4743 O  O   . SER   B 1 355 ? -5.23245  -13.09188 65.92302 1.000 45.72932 ? 355 SER   B O   1 
ATOM   4744 C  CB  . SER   B 1 355 ? -6.94655  -12.84276 63.12354 1.000 42.73605 ? 355 SER   B CB  1 
ATOM   4745 O  OG  . SER   B 1 355 ? -7.22842  -13.52866 61.91704 1.000 42.70511 ? 355 SER   B OG  1 
ATOM   4746 N  N   . PRO   B 1 356 ? -5.00023  -11.08684 64.93646 1.000 47.68271 ? 356 PRO   B N   1 
ATOM   4747 C  CA  . PRO   B 1 356 ? -4.79092  -10.40067 66.21698 1.000 46.05566 ? 356 PRO   B CA  1 
ATOM   4748 C  C   . PRO   B 1 356 ? -5.86486  -10.74742 67.24100 1.000 47.92680 ? 356 PRO   B C   1 
ATOM   4749 O  O   . PRO   B 1 356 ? -7.04780  -10.87370 66.91677 1.000 46.77265 ? 356 PRO   B O   1 
ATOM   4750 C  CB  . PRO   B 1 356 ? -4.83912  -8.91395  65.83377 1.000 43.88581 ? 356 PRO   B CB  1 
ATOM   4751 C  CG  . PRO   B 1 356 ? -4.93584  -8.86539  64.30814 1.000 41.99442 ? 356 PRO   B CG  1 
ATOM   4752 C  CD  . PRO   B 1 356 ? -4.61877  -10.23322 63.80222 1.000 45.84881 ? 356 PRO   B CD  1 
ATOM   4753 N  N   . MET   B 1 357 ? -5.42492  -10.93439 68.48540 1.000 43.61916 ? 357 MET   B N   1 
ATOM   4754 C  CA  . MET   B 1 357 ? -6.27083  -11.17291 69.65201 1.000 37.72418 ? 357 MET   B CA  1 
ATOM   4755 C  C   . MET   B 1 357 ? -7.08602  -12.45814 69.55590 1.000 38.67417 ? 357 MET   B C   1 
ATOM   4756 O  O   . MET   B 1 357 ? -7.98663  -12.67535 70.37616 1.000 34.03986 ? 357 MET   B O   1 
ATOM   4757 C  CB  . MET   B 1 357 ? -7.20300  -9.98241  69.91055 1.000 31.94156 ? 357 MET   B CB  1 
ATOM   4758 C  CG  . MET   B 1 357 ? -6.47408  -8.73735  70.37922 1.000 39.27005 ? 357 MET   B CG  1 
ATOM   4759 S  SD  . MET   B 1 357 ? -7.32673  -7.21395  69.94041 1.000 50.86075 ? 357 MET   B SD  1 
ATOM   4760 C  CE  . MET   B 1 357 ? -6.07658  -6.00239  70.35860 1.000 34.59796 ? 357 MET   B CE  1 
ATOM   4761 N  N   . CYS   B 1 358 ? -6.79382  -13.32257 68.58694 1.000 37.92648 ? 358 CYS   B N   1 
ATOM   4762 C  CA  . CYS   B 1 358 ? -7.52500  -14.56970 68.41155 1.000 38.48563 ? 358 CYS   B CA  1 
ATOM   4763 C  C   . CYS   B 1 358 ? -6.74209  -15.78755 68.88327 1.000 29.58109 ? 358 CYS   B C   1 
ATOM   4764 O  O   . CYS   B 1 358 ? -7.21609  -16.91535 68.71577 1.000 31.95965 ? 358 CYS   B O   1 
ATOM   4765 C  CB  . CYS   B 1 358 ? -7.92127  -14.74483 66.94198 1.000 32.73881 ? 358 CYS   B CB  1 
ATOM   4766 S  SG  . CYS   B 1 358 ? -9.09327  -13.50382 66.33822 1.000 32.39239 ? 358 CYS   B SG  1 
ATOM   4767 N  N   . ASP   B 1 359 ? -5.56620  -15.58635 69.47300 1.000 36.81936 ? 359 ASP   B N   1 
ATOM   4768 C  CA  . ASP   B 1 359 ? -4.69936  -16.67133 69.92858 1.000 33.03073 ? 359 ASP   B CA  1 
ATOM   4769 C  C   . ASP   B 1 359 ? -4.97510  -16.90371 71.41013 1.000 34.57318 ? 359 ASP   B C   1 
ATOM   4770 O  O   . ASP   B 1 359 ? -4.51592  -16.14065 72.26266 1.000 39.85588 ? 359 ASP   B O   1 
ATOM   4771 C  CB  . ASP   B 1 359 ? -3.23581  -16.32029 69.67911 1.000 38.88361 ? 359 ASP   B CB  1 
ATOM   4772 C  CG  . ASP   B 1 359 ? -2.30461  -17.50048 69.87712 1.000 41.53694 ? 359 ASP   B CG  1 
ATOM   4773 O  OD1 . ASP   B 1 359 ? -2.78310  -18.58968 70.25659 1.000 35.55773 ? 359 ASP   B OD1 1 
ATOM   4774 O  OD2 . ASP   B 1 359 ? -1.08630  -17.33330 69.65522 1.000 41.31902 ? 359 ASP   B OD2 1 
ATOM   4775 N  N   . LYS   B 1 360 ? -5.71967  -17.96910 71.71864 1.000 33.42827 ? 360 LYS   B N   1 
ATOM   4776 C  CA  . LYS   B 1 360 ? -6.06373  -18.25200 73.10789 1.000 36.01120 ? 360 LYS   B CA  1 
ATOM   4777 C  C   . LYS   B 1 360 ? -4.84366  -18.59961 73.95139 1.000 46.66104 ? 360 LYS   B C   1 
ATOM   4778 O  O   . LYS   B 1 360 ? -4.90894  -18.49986 75.18095 1.000 48.13733 ? 360 LYS   B O   1 
ATOM   4779 C  CB  . LYS   B 1 360 ? -7.08652  -19.38694 73.18268 1.000 37.36429 ? 360 LYS   B CB  1 
ATOM   4780 C  CG  . LYS   B 1 360 ? -6.54789  -20.74704 72.77482 1.000 36.09571 ? 360 LYS   B CG  1 
ATOM   4781 C  CD  . LYS   B 1 360 ? -7.65411  -21.78865 72.75905 1.000 39.95795 ? 360 LYS   B CD  1 
ATOM   4782 C  CE  . LYS   B 1 360 ? -7.15632  -23.11783 72.21742 1.000 38.00545 ? 360 LYS   B CE  1 
ATOM   4783 N  NZ  . LYS   B 1 360 ? -8.27495  -24.07527 71.99671 1.000 37.85184 ? 360 LYS   B NZ  1 
ATOM   4784 N  N   . HIS   B 1 361 ? -3.73782  -18.99730 73.32716 1.000 46.15236 ? 361 HIS   B N   1 
ATOM   4785 C  CA  . HIS   B 1 361 ? -2.50976  -19.30334 74.04622 1.000 45.73136 ? 361 HIS   B CA  1 
ATOM   4786 C  C   . HIS   B 1 361 ? -1.62226  -18.07985 74.25602 1.000 46.47376 ? 361 HIS   B C   1 
ATOM   4787 O  O   . HIS   B 1 361 ? -0.54302  -18.21465 74.84515 1.000 50.01007 ? 361 HIS   B O   1 
ATOM   4788 C  CB  . HIS   B 1 361 ? -1.71315  -20.38238 73.30390 1.000 41.74687 ? 361 HIS   B CB  1 
ATOM   4789 C  CG  . HIS   B 1 361 ? -2.49458  -21.62659 73.01472 1.000 36.98781 ? 361 HIS   B CG  1 
ATOM   4790 N  ND1 . HIS   B 1 361 ? -3.11151  -22.36556 74.00125 1.000 43.22008 ? 361 HIS   B ND1 1 
ATOM   4791 C  CD2 . HIS   B 1 361 ? -2.74446  -22.27186 71.85044 1.000 40.96107 ? 361 HIS   B CD2 1 
ATOM   4792 C  CE1 . HIS   B 1 361 ? -3.71573  -23.40673 73.45654 1.000 43.78707 ? 361 HIS   B CE1 1 
ATOM   4793 N  NE2 . HIS   B 1 361 ? -3.50790  -23.37361 72.15250 1.000 44.19158 ? 361 HIS   B NE2 1 
ATOM   4794 N  N   . ASN   B 1 362 ? -2.03858  -16.89595 73.79184 1.000 42.15266 ? 362 ASN   B N   1 
ATOM   4795 C  CA  . ASN   B 1 362 ? -1.19489  -15.70832 73.87967 1.000 50.39252 ? 362 ASN   B CA  1 
ATOM   4796 C  C   . ASN   B 1 362 ? -2.06074  -14.44951 73.82169 1.000 49.66016 ? 362 ASN   B C   1 
ATOM   4797 O  O   . ASN   B 1 362 ? -1.68279  -13.43986 73.21722 1.000 49.39829 ? 362 ASN   B O   1 
ATOM   4798 C  CB  . ASN   B 1 362 ? -0.13667  -15.69558 72.77223 1.000 51.06968 ? 362 ASN   B CB  1 
ATOM   4799 C  CG  . ASN   B 1 362 ? 0.84032   -14.54039 72.90095 1.000 55.57936 ? 362 ASN   B CG  1 
ATOM   4800 O  OD1 . ASN   B 1 362 ? 1.38355   -14.05480 71.90427 1.000 59.86569 ? 362 ASN   B OD1 1 
ATOM   4801 N  ND2 . ASN   B 1 362 ? 1.07020   -14.09305 74.11370 1.000 63.29006 ? 362 ASN   B ND2 1 
ATOM   4802 N  N   . ALA   B 1 363 ? -3.23222  -14.49537 74.45000 1.000 39.34882 ? 363 ALA   B N   1 
ATOM   4803 C  CA  . ALA   B 1 363 ? -4.15632  -13.37180 74.45838 1.000 45.26688 ? 363 ALA   B CA  1 
ATOM   4804 C  C   . ALA   B 1 363 ? -4.16921  -12.71432 75.82959 1.000 41.29903 ? 363 ALA   B C   1 
ATOM   4805 O  O   . ALA   B 1 363 ? -4.16515  -13.39667 76.85919 1.000 39.55268 ? 363 ALA   B O   1 
ATOM   4806 C  CB  . ALA   B 1 363 ? -5.56966  -13.81270 74.08359 1.000 40.57398 ? 363 ALA   B CB  1 
ATOM   4807 N  N   . SER   B 1 364 ? -4.18198  -11.38769 75.82960 1.000 31.12862 ? 364 SER   B N   1 
ATOM   4808 C  CA  . SER   B 1 364 ? -4.31954  -10.57720 77.03330 1.000 31.36186 ? 364 SER   B CA  1 
ATOM   4809 C  C   . SER   B 1 364 ? -5.67371  -9.87562  76.93297 1.000 28.62092 ? 364 SER   B C   1 
ATOM   4810 O  O   . SER   B 1 364 ? -5.78228  -8.78059  76.37814 1.000 22.24774 ? 364 SER   B O   1 
ATOM   4811 C  CB  . SER   B 1 364 ? -3.16386  -9.58758  77.16171 1.000 38.55559 ? 364 SER   B CB  1 
ATOM   4812 O  OG  . SER   B 1 364 ? -1.91308  -10.24789 77.05121 1.000 49.97933 ? 364 SER   B OG  1 
ATOM   4813 N  N   . VAL   B 1 365 ? -6.70831  -10.52505 77.47704 1.000 19.92441 ? 365 VAL   B N   1 
ATOM   4814 C  CA  . VAL   B 1 365 ? -8.08116  -10.04873 77.31025 1.000 23.46146 ? 365 VAL   B CA  1 
ATOM   4815 C  C   . VAL   B 1 365 ? -8.23597  -8.63357  77.85290 1.000 25.64840 ? 365 VAL   B C   1 
ATOM   4816 O  O   . VAL   B 1 365 ? -8.88832  -7.78293  77.23452 1.000 24.24716 ? 365 VAL   B O   1 
ATOM   4817 C  CB  . VAL   B 1 365 ? -9.06643  -11.02234 77.98617 1.000 26.47963 ? 365 VAL   B CB  1 
ATOM   4818 C  CG1 . VAL   B 1 365 ? -10.47925 -10.45005 77.98401 1.000 23.28764 ? 365 VAL   B CG1 1 
ATOM   4819 C  CG2 . VAL   B 1 365 ? -9.03522  -12.37771 77.29620 1.000 25.06725 ? 365 VAL   B CG2 1 
ATOM   4820 N  N   . GLU   B 1 366 ? -7.63040  -8.35384  79.00721 1.000 22.23065 ? 366 GLU   B N   1 
ATOM   4821 C  CA  . GLU   B 1 366 ? -7.84836  -7.07095  79.66568 1.000 22.23828 ? 366 GLU   B CA  1 
ATOM   4822 C  C   . GLU   B 1 366 ? -7.04825  -5.95276  79.00631 1.000 25.02836 ? 366 GLU   B C   1 
ATOM   4823 O  O   . GLU   B 1 366 ? -7.54686  -4.82948  78.87199 1.000 23.44281 ? 366 GLU   B O   1 
ATOM   4824 C  CB  . GLU   B 1 366 ? -7.50621  -7.18344  81.15208 1.000 19.10853 ? 366 GLU   B CB  1 
ATOM   4825 C  CG  . GLU   B 1 366 ? -8.35197  -8.20662  81.91013 1.000 20.86028 ? 366 GLU   B CG  1 
ATOM   4826 C  CD  . GLU   B 1 366 ? -7.88158  -9.63714  81.70002 1.000 24.15060 ? 366 GLU   B CD  1 
ATOM   4827 O  OE1 . GLU   B 1 366 ? -8.69058  -10.56856 81.89461 1.000 19.32384 ? 366 GLU   B OE1 1 
ATOM   4828 O  OE2 . GLU   B 1 366 ? -6.70245  -9.82797  81.33618 1.000 23.61967 ? 366 GLU   B OE2 1 
ATOM   4829 N  N   . LYS   B 1 367 ? -5.81069  -6.23463  78.58898 1.000 22.56383 ? 367 LYS   B N   1 
ATOM   4830 C  CA  . LYS   B 1 367 ? -5.04904  -5.23373  77.84922 1.000 27.57342 ? 367 LYS   B CA  1 
ATOM   4831 C  C   . LYS   B 1 367 ? -5.67338  -4.95374  76.48849 1.000 25.31333 ? 367 LYS   B C   1 
ATOM   4832 O  O   . LYS   B 1 367 ? -5.57214  -3.83175  75.97978 1.000 23.54661 ? 367 LYS   B O   1 
ATOM   4833 C  CB  . LYS   B 1 367 ? -3.59433  -5.67887  77.68843 1.000 28.37649 ? 367 LYS   B CB  1 
ATOM   4834 C  CG  . LYS   B 1 367 ? -2.85047  -5.83975  79.00542 1.000 36.32450 ? 367 LYS   B CG  1 
ATOM   4835 C  CD  . LYS   B 1 367 ? -1.38862  -5.42715  78.88736 1.000 43.51509 ? 367 LYS   B CD  1 
ATOM   4836 C  CE  . LYS   B 1 367 ? -0.54253  -6.51163  78.24071 1.000 49.76314 ? 367 LYS   B CE  1 
ATOM   4837 N  NZ  . LYS   B 1 367 ? 0.89318   -6.37777  78.61960 1.000 53.56318 ? 367 LYS   B NZ  1 
ATOM   4838 N  N   . SER   B 1 368 ? -6.32261  -5.95249  75.88808 1.000 23.12570 ? 368 SER   B N   1 
ATOM   4839 C  CA  . SER   B 1 368 ? -7.00628  -5.73098  74.61873 1.000 27.58535 ? 368 SER   B CA  1 
ATOM   4840 C  C   . SER   B 1 368 ? -8.21263  -4.81823  74.80126 1.000 25.07181 ? 368 SER   B C   1 
ATOM   4841 O  O   . SER   B 1 368 ? -8.42079  -3.88514  74.01679 1.000 24.56586 ? 368 SER   B O   1 
ATOM   4842 C  CB  . SER   B 1 368 ? -7.42637  -7.06823  74.00802 1.000 24.90587 ? 368 SER   B CB  1 
ATOM   4843 O  OG  . SER   B 1 368 ? -6.29643  -7.83280  73.62675 1.000 30.02799 ? 368 SER   B OG  1 
ATOM   4844 N  N   . GLN   B 1 369 ? -9.01697  -5.07121  75.83890 1.000 21.62335 ? 369 GLN   B N   1 
ATOM   4845 C  CA  . GLN   B 1 369 ? -10.18952 -4.23864  76.09189 1.000 22.65595 ? 369 GLN   B CA  1 
ATOM   4846 C  C   . GLN   B 1 369 ? -9.80293  -2.78096  76.30021 1.000 23.33408 ? 369 GLN   B C   1 
ATOM   4847 O  O   . GLN   B 1 369 ? -10.45185 -1.87659  75.76146 1.000 23.35040 ? 369 GLN   B O   1 
ATOM   4848 C  CB  . GLN   B 1 369 ? -10.95938 -4.76166  77.30485 1.000 20.54727 ? 369 GLN   B CB  1 
ATOM   4849 C  CG  . GLN   B 1 369 ? -11.93266 -5.87385  76.97726 1.000 22.62500 ? 369 GLN   B CG  1 
ATOM   4850 C  CD  . GLN   B 1 369 ? -12.75965 -5.56456  75.74677 1.000 24.72904 ? 369 GLN   B CD  1 
ATOM   4851 O  OE1 . GLN   B 1 369 ? -13.50034 -4.58144  75.71251 1.000 22.60800 ? 369 GLN   B OE1 1 
ATOM   4852 N  NE2 . GLN   B 1 369 ? -12.63061 -6.40026  74.72285 1.000 19.95904 ? 369 GLN   B NE2 1 
ATOM   4853 N  N   . VAL   B 1 370 ? -8.74356  -2.53053  77.07232 1.000 25.43420 ? 370 VAL   B N   1 
ATOM   4854 C  CA  . VAL   B 1 370 ? -8.35650  -1.15001  77.33644 1.000 26.99993 ? 370 VAL   B CA  1 
ATOM   4855 C  C   . VAL   B 1 370 ? -7.74684  -0.51158  76.09282 1.000 26.79595 ? 370 VAL   B C   1 
ATOM   4856 O  O   . VAL   B 1 370 ? -7.84759  0.70605   75.90232 1.000 23.52611 ? 370 VAL   B O   1 
ATOM   4857 C  CB  . VAL   B 1 370 ? -7.41007  -1.07766  78.55100 1.000 29.95315 ? 370 VAL   B CB  1 
ATOM   4858 C  CG1 . VAL   B 1 370 ? -8.07996  -1.66747  79.77775 1.000 24.57695 ? 370 VAL   B CG1 1 
ATOM   4859 C  CG2 . VAL   B 1 370 ? -6.10136  -1.78524  78.27375 1.000 34.24291 ? 370 VAL   B CG2 1 
ATOM   4860 N  N   . GLY   B 1 371 ? -7.12099  -1.30712  75.22268 1.000 26.75376 ? 371 GLY   B N   1 
ATOM   4861 C  CA  . GLY   B 1 371 ? -6.67137  -0.77200  73.94740 1.000 26.02401 ? 371 GLY   B CA  1 
ATOM   4862 C  C   . GLY   B 1 371 ? -7.82563  -0.51852  72.99698 1.000 27.75477 ? 371 GLY   B C   1 
ATOM   4863 O  O   . GLY   B 1 371 ? -7.84618  0.48801   72.28227 1.000 32.43545 ? 371 GLY   B O   1 
ATOM   4864 N  N   . PHE   B 1 372 ? -8.79771  -1.43466  72.97437 1.000 22.06037 ? 372 PHE   B N   1 
ATOM   4865 C  CA  . PHE   B 1 372 ? -10.03188 -1.22977  72.22223 1.000 23.99629 ? 372 PHE   B CA  1 
ATOM   4866 C  C   . PHE   B 1 372 ? -10.70511 0.07902   72.61663 1.000 25.93858 ? 372 PHE   B C   1 
ATOM   4867 O  O   . PHE   B 1 372 ? -11.20229 0.81767   71.75839 1.000 24.88571 ? 372 PHE   B O   1 
ATOM   4868 C  CB  . PHE   B 1 372 ? -10.95964 -2.42539  72.46186 1.000 25.37317 ? 372 PHE   B CB  1 
ATOM   4869 C  CG  . PHE   B 1 372 ? -12.25559 -2.37984  71.69824 1.000 23.52629 ? 372 PHE   B CG  1 
ATOM   4870 C  CD1 . PHE   B 1 372 ? -12.28153 -2.07495  70.34731 1.000 20.73875 ? 372 PHE   B CD1 1 
ATOM   4871 C  CD2 . PHE   B 1 372 ? -13.44907 -2.69330  72.33187 1.000 21.83308 ? 372 PHE   B CD2 1 
ATOM   4872 C  CE1 . PHE   B 1 372 ? -13.47967 -2.05428  69.65024 1.000 21.43023 ? 372 PHE   B CE1 1 
ATOM   4873 C  CE2 . PHE   B 1 372 ? -14.64705 -2.67885  71.64208 1.000 23.15567 ? 372 PHE   B CE2 1 
ATOM   4874 C  CZ  . PHE   B 1 372 ? -14.66291 -2.35847  70.29923 1.000 20.63980 ? 372 PHE   B CZ  1 
ATOM   4875 N  N   . ILE   B 1 373 ? -10.70721 0.39281   73.91329 1.000 23.20286 ? 373 ILE   B N   1 
ATOM   4876 C  CA  . ILE   B 1 373 ? -11.32687 1.62693   74.38601 1.000 27.15556 ? 373 ILE   B CA  1 
ATOM   4877 C  C   . ILE   B 1 373 ? -10.47776 2.83374   74.00318 1.000 25.78929 ? 373 ILE   B C   1 
ATOM   4878 O  O   . ILE   B 1 373 ? -10.99189 3.84002   73.50152 1.000 32.08045 ? 373 ILE   B O   1 
ATOM   4879 C  CB  . ILE   B 1 373 ? -11.55807 1.55854   75.90676 1.000 29.33044 ? 373 ILE   B CB  1 
ATOM   4880 C  CG1 . ILE   B 1 373 ? -12.65341 0.54180   76.23529 1.000 27.69733 ? 373 ILE   B CG1 1 
ATOM   4881 C  CG2 . ILE   B 1 373 ? -11.90745 2.93253   76.46221 1.000 23.18922 ? 373 ILE   B CG2 1 
ATOM   4882 C  CD1 . ILE   B 1 373 ? -12.89967 0.36756   77.71810 1.000 26.22372 ? 373 ILE   B CD1 1 
ATOM   4883 N  N   . ASP   B 1 374 ? -9.16336  2.74850   74.22485 1.000 25.83615 ? 374 ASP   B N   1 
ATOM   4884 C  CA  . ASP   B 1 374 ? -8.30006  3.90673   74.00953 1.000 31.37719 ? 374 ASP   B CA  1 
ATOM   4885 C  C   . ASP   B 1 374 ? -8.24312  4.30701   72.54021 1.000 35.20145 ? 374 ASP   B C   1 
ATOM   4886 O  O   . ASP   B 1 374 ? -8.17943  5.49963   72.22085 1.000 37.88295 ? 374 ASP   B O   1 
ATOM   4887 C  CB  . ASP   B 1 374 ? -6.89110  3.62232   74.53162 1.000 30.89798 ? 374 ASP   B CB  1 
ATOM   4888 C  CG  . ASP   B 1 374 ? -6.83600  3.52183   76.04278 1.000 29.67649 ? 374 ASP   B CG  1 
ATOM   4889 O  OD1 . ASP   B 1 374 ? -7.80949  3.93798   76.70489 1.000 24.50556 ? 374 ASP   B OD1 1 
ATOM   4890 O  OD2 . ASP   B 1 374 ? -5.81457  3.03160   76.56853 1.000 25.00606 ? 374 ASP   B OD2 1 
ATOM   4891 N  N   . TYR   B 1 375 ? -8.26556  3.33338   71.63099 1.000 34.31609 ? 375 TYR   B N   1 
ATOM   4892 C  CA  . TYR   B 1 375 ? -8.00520  3.61852   70.22695 1.000 36.51512 ? 375 TYR   B CA  1 
ATOM   4893 C  C   . TYR   B 1 375 ? -9.25021  3.63103   69.35204 1.000 33.06138 ? 375 TYR   B C   1 
ATOM   4894 O  O   . TYR   B 1 375 ? -9.19865  4.18345   68.24779 1.000 33.48059 ? 375 TYR   B O   1 
ATOM   4895 C  CB  . TYR   B 1 375 ? -6.99890  2.60786   69.66365 1.000 39.59978 ? 375 TYR   B CB  1 
ATOM   4896 C  CG  . TYR   B 1 375 ? -5.60153  2.82864   70.18995 1.000 40.47001 ? 375 TYR   B CG  1 
ATOM   4897 C  CD1 . TYR   B 1 375 ? -4.91990  4.00524   69.91247 1.000 46.45262 ? 375 TYR   B CD1 1 
ATOM   4898 C  CD2 . TYR   B 1 375 ? -4.96829  1.87255   70.97282 1.000 43.02363 ? 375 TYR   B CD2 1 
ATOM   4899 C  CE1 . TYR   B 1 375 ? -3.64613  4.22369   70.39305 1.000 51.41599 ? 375 TYR   B CE1 1 
ATOM   4900 C  CE2 . TYR   B 1 375 ? -3.68998  2.08195   71.45858 1.000 45.80859 ? 375 TYR   B CE2 1 
ATOM   4901 C  CZ  . TYR   B 1 375 ? -3.03483  3.26043   71.16474 1.000 52.84583 ? 375 TYR   B CZ  1 
ATOM   4902 O  OH  . TYR   B 1 375 ? -1.76349  3.48015   71.64246 1.000 57.94668 ? 375 TYR   B OH  1 
ATOM   4903 N  N   . ILE   B 1 376 ? -10.36201 3.05683   69.80716 1.000 29.93616 ? 376 ILE   B N   1 
ATOM   4904 C  CA  . ILE   B 1 376 ? -11.55490 2.97951   68.97135 1.000 24.09800 ? 376 ILE   B CA  1 
ATOM   4905 C  C   . ILE   B 1 376 ? -12.76777 3.54577   69.69784 1.000 26.11288 ? 376 ILE   B C   1 
ATOM   4906 O  O   . ILE   B 1 376 ? -13.40136 4.49348   69.22136 1.000 23.72459 ? 376 ILE   B O   1 
ATOM   4907 C  CB  . ILE   B 1 376 ? -11.82509 1.53152   68.52211 1.000 25.13378 ? 376 ILE   B CB  1 
ATOM   4908 C  CG1 . ILE   B 1 376 ? -10.65894 0.99835   67.68732 1.000 27.82582 ? 376 ILE   B CG1 1 
ATOM   4909 C  CG2 . ILE   B 1 376 ? -13.12294 1.45550   67.73333 1.000 18.55254 ? 376 ILE   B CG2 1 
ATOM   4910 C  CD1 . ILE   B 1 376 ? -10.41298 1.77496   66.41232 1.000 33.04620 ? 376 ILE   B CD1 1 
ATOM   4911 N  N   . VAL   B 1 377 ? -13.09560 2.97356   70.85800 1.000 24.82442 ? 377 VAL   B N   1 
ATOM   4912 C  CA  . VAL   B 1 377 ? -14.39907 3.22628   71.46697 1.000 25.47868 ? 377 VAL   B CA  1 
ATOM   4913 C  C   . VAL   B 1 377 ? -14.45833 4.61657   72.09086 1.000 28.34658 ? 377 VAL   B C   1 
ATOM   4914 O  O   . VAL   B 1 377 ? -15.47172 5.31655   71.97409 1.000 25.19482 ? 377 VAL   B O   1 
ATOM   4915 C  CB  . VAL   B 1 377 ? -14.72533 2.12632   72.49232 1.000 22.45835 ? 377 VAL   B CB  1 
ATOM   4916 C  CG1 . VAL   B 1 377 ? -16.06178 2.39907   73.16379 1.000 20.08286 ? 377 VAL   B CG1 1 
ATOM   4917 C  CG2 . VAL   B 1 377 ? -14.74445 0.77641   71.81034 1.000 25.91965 ? 377 VAL   B CG2 1 
ATOM   4918 N  N   . HIS   B 1 378 ? -13.39117 5.04068   72.76563 1.000 28.36749 ? 378 HIS   B N   1 
ATOM   4919 C  CA  . HIS   B 1 378 ? -13.44112 6.34408   73.42136 1.000 30.49784 ? 378 HIS   B CA  1 
ATOM   4920 C  C   . HIS   B 1 378 ? -13.26442 7.49712   72.43453 1.000 30.04992 ? 378 HIS   B C   1 
ATOM   4921 O  O   . HIS   B 1 378 ? -14.02340 8.47167   72.51503 1.000 32.16606 ? 378 HIS   B O   1 
ATOM   4922 C  CB  . HIS   B 1 378 ? -12.40307 6.44928   74.54021 1.000 24.94370 ? 378 HIS   B CB  1 
ATOM   4923 C  CG  . HIS   B 1 378 ? -12.63875 7.60358   75.46386 1.000 31.51498 ? 378 HIS   B CG  1 
ATOM   4924 N  ND1 . HIS   B 1 378 ? -11.99487 8.81420   75.32472 1.000 33.73131 ? 378 HIS   B ND1 1 
ATOM   4925 C  CD2 . HIS   B 1 378 ? -13.46081 7.73586   76.53166 1.000 31.86481 ? 378 HIS   B CD2 1 
ATOM   4926 C  CE1 . HIS   B 1 378 ? -12.40401 9.63959   76.27175 1.000 32.55470 ? 378 HIS   B CE1 1 
ATOM   4927 N  NE2 . HIS   B 1 378 ? -13.29359 9.00974   77.01760 1.000 35.87125 ? 378 HIS   B NE2 1 
ATOM   4928 N  N   . PRO   B 1 379 ? -12.28758 7.45873   71.50955 1.000 33.04094 ? 379 PRO   B N   1 
ATOM   4929 C  CA  . PRO   B 1 379 ? -12.24379 8.51759   70.48438 1.000 28.49243 ? 379 PRO   B CA  1 
ATOM   4930 C  C   . PRO   B 1 379 ? -13.56499 8.66975   69.75954 1.000 30.63484 ? 379 PRO   B C   1 
ATOM   4931 O  O   . PRO   B 1 379 ? -13.97946 9.78743   69.42847 1.000 35.13290 ? 379 PRO   B O   1 
ATOM   4932 C  CB  . PRO   B 1 379 ? -11.13194 8.04621   69.53802 1.000 30.28038 ? 379 PRO   B CB  1 
ATOM   4933 C  CG  . PRO   B 1 379 ? -10.26110 7.20297   70.37577 1.000 31.45394 ? 379 PRO   B CG  1 
ATOM   4934 C  CD  . PRO   B 1 379 ? -11.16781 6.51036   71.34806 1.000 28.72297 ? 379 PRO   B CD  1 
ATOM   4935 N  N   . LEU   B 1 380 ? -14.24927 7.55089   69.52888 1.000 29.94617 ? 380 LEU   B N   1 
ATOM   4936 C  CA  . LEU   B 1 380 ? -15.55293 7.57761   68.88160 1.000 30.43760 ? 380 LEU   B CA  1 
ATOM   4937 C  C   . LEU   B 1 380 ? -16.60114 8.22306   69.78055 1.000 30.63112 ? 380 LEU   B C   1 
ATOM   4938 O  O   . LEU   B 1 380 ? -17.25337 9.19995   69.39442 1.000 30.86342 ? 380 LEU   B O   1 
ATOM   4939 C  CB  . LEU   B 1 380 ? -15.96351 6.15483   68.50890 1.000 27.26824 ? 380 LEU   B CB  1 
ATOM   4940 C  CG  . LEU   B 1 380 ? -17.29522 6.05486   67.78336 1.000 29.30752 ? 380 LEU   B CG  1 
ATOM   4941 C  CD1 . LEU   B 1 380 ? -17.20304 6.80247   66.46049 1.000 30.28712 ? 380 LEU   B CD1 1 
ATOM   4942 C  CD2 . LEU   B 1 380 ? -17.71467 4.60686   67.57800 1.000 29.67284 ? 380 LEU   B CD2 1 
ATOM   4943 N  N   . TRP   B 1 381 ? -16.77817 7.68586   70.99108 1.000 30.57174 ? 381 TRP   B N   1 
ATOM   4944 C  CA  . TRP   B 1 381 ? -17.82274 8.18226   71.87978 1.000 25.89017 ? 381 TRP   B CA  1 
ATOM   4945 C  C   . TRP   B 1 381 ? -17.52470 9.57480   72.42269 1.000 31.91167 ? 381 TRP   B C   1 
ATOM   4946 O  O   . TRP   B 1 381 ? -18.45918 10.27748  72.82119 1.000 33.41845 ? 381 TRP   B O   1 
ATOM   4947 C  CB  . TRP   B 1 381 ? -18.04596 7.20400   73.03553 1.000 25.67912 ? 381 TRP   B CB  1 
ATOM   4948 C  CG  . TRP   B 1 381 ? -18.98315 6.07976   72.69136 1.000 23.49683 ? 381 TRP   B CG  1 
ATOM   4949 C  CD1 . TRP   B 1 381 ? -18.64308 4.81444   72.30864 1.000 23.40174 ? 381 TRP   B CD1 1 
ATOM   4950 C  CD2 . TRP   B 1 381 ? -20.41623 6.12625   72.69141 1.000 21.54792 ? 381 TRP   B CD2 1 
ATOM   4951 N  NE1 . TRP   B 1 381 ? -19.77456 4.06974   72.07495 1.000 22.26395 ? 381 TRP   B NE1 1 
ATOM   4952 C  CE2 . TRP   B 1 381 ? -20.87598 4.85210   72.30270 1.000 22.61472 ? 381 TRP   B CE2 1 
ATOM   4953 C  CE3 . TRP   B 1 381 ? -21.35438 7.12089   72.98459 1.000 22.99921 ? 381 TRP   B CE3 1 
ATOM   4954 C  CZ2 . TRP   B 1 381 ? -22.23195 4.54684   72.19948 1.000 21.95460 ? 381 TRP   B CZ2 1 
ATOM   4955 C  CZ3 . TRP   B 1 381 ? -22.69988 6.81572   72.88187 1.000 26.07357 ? 381 TRP   B CZ3 1 
ATOM   4956 C  CH2 . TRP   B 1 381 ? -23.12561 5.53963   72.49222 1.000 29.07769 ? 381 TRP   B CH2 1 
ATOM   4957 N  N   . GLU   B 1 382 ? -16.25701 9.99390   72.45197 1.000 29.36448 ? 382 GLU   B N   1 
ATOM   4958 C  CA  . GLU   B 1 382 ? -15.96530 11.36884  72.84500 1.000 37.05557 ? 382 GLU   B CA  1 
ATOM   4959 C  C   . GLU   B 1 382 ? -16.29792 12.34398  71.72273 1.000 38.04775 ? 382 GLU   B C   1 
ATOM   4960 O  O   . GLU   B 1 382 ? -16.77015 13.45664  71.98275 1.000 35.03817 ? 382 GLU   B O   1 
ATOM   4961 C  CB  . GLU   B 1 382 ? -14.50033 11.51635  73.25957 1.000 32.24995 ? 382 GLU   B CB  1 
ATOM   4962 C  CG  . GLU   B 1 382 ? -14.15616 12.91489  73.75645 1.000 38.18562 ? 382 GLU   B CG  1 
ATOM   4963 C  CD  . GLU   B 1 382 ? -12.71562 13.05185  74.20467 1.000 47.25334 ? 382 GLU   B CD  1 
ATOM   4964 O  OE1 . GLU   B 1 382 ? -11.81483 12.59494  73.47020 1.000 50.29778 ? 382 GLU   B OE1 1 
ATOM   4965 O  OE2 . GLU   B 1 382 ? -12.48511 13.62179  75.29262 1.000 48.61071 ? 382 GLU   B OE2 1 
ATOM   4966 N  N   . THR   B 1 383 ? -16.05513 11.94657  70.47155 1.000 36.60077 ? 383 THR   B N   1 
ATOM   4967 C  CA  . THR   B 1 383 ? -16.48032 12.76957  69.34463 1.000 33.83206 ? 383 THR   B CA  1 
ATOM   4968 C  C   . THR   B 1 383 ? -17.99935 12.86188  69.28110 1.000 35.43568 ? 383 THR   B C   1 
ATOM   4969 O  O   . THR   B 1 383 ? -18.55308 13.93600  69.01738 1.000 39.63464 ? 383 THR   B O   1 
ATOM   4970 C  CB  . THR   B 1 383 ? -15.92494 12.20402  68.03785 1.000 29.90867 ? 383 THR   B CB  1 
ATOM   4971 O  OG1 . THR   B 1 383 ? -14.49520 12.13406  68.11370 1.000 29.94763 ? 383 THR   B OG1 1 
ATOM   4972 C  CG2 . THR   B 1 383 ? -16.32268 13.08649  66.86499 1.000 31.03349 ? 383 THR   B CG2 1 
ATOM   4973 N  N   . TRP   B 1 384 ? -18.68818 11.74447  69.52798 1.000 29.58945 ? 384 TRP   B N   1 
ATOM   4974 C  CA  . TRP   B 1 384 ? -20.14720 11.75370  69.53937 1.000 30.46209 ? 384 TRP   B CA  1 
ATOM   4975 C  C   . TRP   B 1 384 ? -20.68520 12.57506  70.70439 1.000 37.13980 ? 384 TRP   B C   1 
ATOM   4976 O  O   . TRP   B 1 384 ? -21.69874 13.26941  70.56405 1.000 36.51985 ? 384 TRP   B O   1 
ATOM   4977 C  CB  . TRP   B 1 384 ? -20.67732 10.32059  69.59809 1.000 29.20295 ? 384 TRP   B CB  1 
ATOM   4978 C  CG  . TRP   B 1 384 ? -22.16435 10.22885  69.77212 1.000 27.26821 ? 384 TRP   B CG  1 
ATOM   4979 C  CD1 . TRP   B 1 384 ? -22.84944 10.17840  70.95157 1.000 33.60972 ? 384 TRP   B CD1 1 
ATOM   4980 C  CD2 . TRP   B 1 384 ? -23.15062 10.17122  68.73314 1.000 34.17408 ? 384 TRP   B CD2 1 
ATOM   4981 N  NE1 . TRP   B 1 384 ? -24.19969 10.09669  70.71222 1.000 26.63487 ? 384 TRP   B NE1 1 
ATOM   4982 C  CE2 . TRP   B 1 384 ? -24.41129 10.09056  69.35855 1.000 30.30136 ? 384 TRP   B CE2 1 
ATOM   4983 C  CE3 . TRP   B 1 384 ? -23.09024 10.18122  67.33597 1.000 27.87737 ? 384 TRP   B CE3 1 
ATOM   4984 C  CZ2 . TRP   B 1 384 ? -25.60079 10.01996  68.63552 1.000 33.59960 ? 384 TRP   B CZ2 1 
ATOM   4985 C  CZ3 . TRP   B 1 384 ? -24.27320 10.11124  66.61959 1.000 25.89313 ? 384 TRP   B CZ3 1 
ATOM   4986 C  CH2 . TRP   B 1 384 ? -25.51095 10.03156  67.27084 1.000 29.33857 ? 384 TRP   B CH2 1 
ATOM   4987 N  N   . ALA   B 1 385 ? -20.02481 12.50367  71.86399 1.000 33.86759 ? 385 ALA   B N   1 
ATOM   4988 C  CA  . ALA   B 1 385 ? -20.43953 13.31852  73.00163 1.000 39.22501 ? 385 ALA   B CA  1 
ATOM   4989 C  C   . ALA   B 1 385 ? -20.29294 14.80181  72.69379 1.000 32.95251 ? 385 ALA   B C   1 
ATOM   4990 O  O   . ALA   B 1 385 ? -21.12607 15.61549  73.10863 1.000 37.72122 ? 385 ALA   B O   1 
ATOM   4991 C  CB  . ALA   B 1 385 ? -19.62931 12.94538  74.24277 1.000 38.96960 ? 385 ALA   B CB  1 
ATOM   4992 N  N   . ASP   B 1 386 ? -19.23306 15.17118  71.97072 1.000 34.74790 ? 386 ASP   B N   1 
ATOM   4993 C  CA  . ASP   B 1 386 ? -19.08476 16.54968  71.51693 1.000 39.45895 ? 386 ASP   B CA  1 
ATOM   4994 C  C   . ASP   B 1 386 ? -20.24425 16.96160  70.62049 1.000 44.26667 ? 386 ASP   B C   1 
ATOM   4995 O  O   . ASP   B 1 386 ? -20.78502 18.06530  70.75898 1.000 43.79310 ? 386 ASP   B O   1 
ATOM   4996 C  CB  . ASP   B 1 386 ? -17.75906 16.71594  70.77480 1.000 35.16942 ? 386 ASP   B CB  1 
ATOM   4997 C  CG  . ASP   B 1 386 ? -16.58096 16.88589  71.71058 1.000 41.90518 ? 386 ASP   B CG  1 
ATOM   4998 O  OD1 . ASP   B 1 386 ? -16.75879 16.72390  72.93640 1.000 31.44580 ? 386 ASP   B OD1 1 
ATOM   4999 O  OD2 . ASP   B 1 386 ? -15.47270 17.17961  71.21530 1.000 43.11107 ? 386 ASP   B OD2 1 
ATOM   5000 N  N   . LEU   B 1 387 ? -20.63784 16.08395  69.69349 1.000 42.49012 ? 387 LEU   B N   1 
ATOM   5001 C  CA  . LEU   B 1 387 ? -21.71376 16.41044  68.76292 1.000 40.85075 ? 387 LEU   B CA  1 
ATOM   5002 C  C   . LEU   B 1 387 ? -23.01636 16.70297  69.49658 1.000 41.92578 ? 387 LEU   B C   1 
ATOM   5003 O  O   . LEU   B 1 387 ? -23.76495 17.60871  69.11134 1.000 42.75712 ? 387 LEU   B O   1 
ATOM   5004 C  CB  . LEU   B 1 387 ? -21.91175 15.26603  67.76891 1.000 39.42902 ? 387 LEU   B CB  1 
ATOM   5005 C  CG  . LEU   B 1 387 ? -23.06934 15.44281  66.78452 1.000 39.37220 ? 387 LEU   B CG  1 
ATOM   5006 C  CD1 . LEU   B 1 387 ? -22.64921 16.33623  65.63168 1.000 37.43921 ? 387 LEU   B CD1 1 
ATOM   5007 C  CD2 . LEU   B 1 387 ? -23.57699 14.10008  66.28010 1.000 35.27797 ? 387 LEU   B CD2 1 
ATOM   5008 N  N   . VAL   B 1 388 ? -23.30102 15.95257  70.55858 1.000 39.33958 ? 388 VAL   B N   1 
ATOM   5009 C  CA  . VAL   B 1 388 ? -24.55468 16.09035  71.28989 1.000 37.89273 ? 388 VAL   B CA  1 
ATOM   5010 C  C   . VAL   B 1 388 ? -24.27949 16.67329  72.67010 1.000 39.79382 ? 388 VAL   B C   1 
ATOM   5011 O  O   . VAL   B 1 388 ? -24.99252 16.38068  73.63602 1.000 41.90860 ? 388 VAL   B O   1 
ATOM   5012 C  CB  . VAL   B 1 388 ? -25.28237 14.73741  71.38306 1.000 39.28323 ? 388 VAL   B CB  1 
ATOM   5013 C  CG1 . VAL   B 1 388 ? -25.55312 14.20322  69.99643 1.000 39.56263 ? 388 VAL   B CG1 1 
ATOM   5014 C  CG2 . VAL   B 1 388 ? -24.45787 13.72989  72.17735 1.000 39.60917 ? 388 VAL   B CG2 1 
ATOM   5015 N  N   . HIS   B 1 389 ? -23.24817 17.50616  72.76302 1.000 43.18201 ? 389 HIS   B N   1 
ATOM   5016 C  CA  . HIS   B 1 389 ? -22.84764 18.15156  74.01178 1.000 45.10222 ? 389 HIS   B CA  1 
ATOM   5017 C  C   . HIS   B 1 389 ? -24.02877 18.78203  74.75612 1.000 46.38393 ? 389 HIS   B C   1 
ATOM   5018 O  O   . HIS   B 1 389 ? -24.68011 19.68543  74.23219 1.000 48.54884 ? 389 HIS   B O   1 
ATOM   5019 C  CB  . HIS   B 1 389 ? -21.78794 19.21874  73.71454 1.000 51.02244 ? 389 HIS   B CB  1 
ATOM   5020 C  CG  . HIS   B 1 389 ? -20.95442 19.60019  74.89812 1.000 55.85432 ? 389 HIS   B CG  1 
ATOM   5021 N  ND1 . HIS   B 1 389 ? -21.46587 20.27682  75.98429 1.000 58.05544 ? 389 HIS   B ND1 1 
ATOM   5022 C  CD2 . HIS   B 1 389 ? -19.63710 19.41909  75.15454 1.000 54.30269 ? 389 HIS   B CD2 1 
ATOM   5023 C  CE1 . HIS   B 1 389 ? -20.50269 20.48493  76.86437 1.000 55.49668 ? 389 HIS   B CE1 1 
ATOM   5024 N  NE2 . HIS   B 1 389 ? -19.38278 19.97471  76.38485 1.000 59.95198 ? 389 HIS   B NE2 1 
ATOM   5025 N  N   . PRO   B 1 390 ? -24.31288 18.30539  75.98114 1.000 52.06008 ? 390 PRO   B N   1 
ATOM   5026 C  CA  . PRO   B 1 390 ? -23.68094 17.15777  76.63244 1.000 49.22155 ? 390 PRO   B CA  1 
ATOM   5027 C  C   . PRO   B 1 390 ? -24.64866 16.05410  77.06848 1.000 48.60637 ? 390 PRO   B C   1 
ATOM   5028 O  O   . PRO   B 1 390 ? -24.54590 15.60996  78.21434 1.000 50.47482 ? 390 PRO   B O   1 
ATOM   5029 C  CB  . PRO   B 1 390 ? -23.05946 17.79725  77.86508 1.000 53.83373 ? 390 PRO   B CB  1 
ATOM   5030 C  CG  . PRO   B 1 390 ? -24.12300 18.81879  78.27023 1.000 52.09454 ? 390 PRO   B CG  1 
ATOM   5031 C  CD  . PRO   B 1 390 ? -24.86732 19.22297  76.99107 1.000 51.24230 ? 390 PRO   B CD  1 
ATOM   5032 N  N   . ASP   B 1 391 ? -25.56201 15.61457  76.20318 1.000 38.65639 ? 391 ASP   B N   1 
ATOM   5033 C  CA  . ASP   B 1 391 ? -26.47288 14.56030  76.63361 1.000 43.86357 ? 391 ASP   B CA  1 
ATOM   5034 C  C   . ASP   B 1 391 ? -25.80678 13.19294  76.69046 1.000 44.33284 ? 391 ASP   B C   1 
ATOM   5035 O  O   . ASP   B 1 391 ? -26.43993 12.22905  77.13751 1.000 36.93086 ? 391 ASP   B O   1 
ATOM   5036 C  CB  . ASP   B 1 391 ? -27.67946 14.48111  75.70898 1.000 41.75209 ? 391 ASP   B CB  1 
ATOM   5037 C  CG  . ASP   B 1 391 ? -28.15590 15.78411  75.26530 1.000 54.14115 ? 391 ASP   B CG  1 
ATOM   5038 O  OD1 . ASP   B 1 391 ? -27.61816 16.30017  74.36147 1.000 50.13284 ? 391 ASP   B OD1 1 
ATOM   5039 O  OD2 . ASP   B 1 391 ? -29.06578 16.30078  75.82398 1.000 56.58600 ? 391 ASP   B OD2 1 
ATOM   5040 N  N   . ALA   B 1 392 ? -24.54861 13.08817  76.27825 1.000 41.38970 ? 392 ALA   B N   1 
ATOM   5041 C  CA  . ALA   B 1 392 ? -23.84881 11.81304  76.27741 1.000 49.27483 ? 392 ALA   B CA  1 
ATOM   5042 C  C   . ALA   B 1 392 ? -22.99497 11.60497  77.51891 1.000 44.14375 ? 392 ALA   B C   1 
ATOM   5043 O  O   . ALA   B 1 392 ? -22.30720 10.58312  77.61100 1.000 42.85753 ? 392 ALA   B O   1 
ATOM   5044 C  CB  . ALA   B 1 392 ? -22.97355 11.69850  75.02627 1.000 37.70473 ? 392 ALA   B CB  1 
ATOM   5045 N  N   . GLN   B 1 393 ? -23.04416 12.53201  78.47952 1.000 41.75103 ? 393 GLN   B N   1 
ATOM   5046 C  CA  . GLN   B 1 393 ? -22.09904 12.50835  79.59190 1.000 44.42824 ? 393 GLN   B CA  1 
ATOM   5047 C  C   . GLN   B 1 393 ? -22.22534 11.22553  80.40547 1.000 35.03655 ? 393 GLN   B C   1 
ATOM   5048 O  O   . GLN   B 1 393 ? -21.21822 10.59070  80.73620 1.000 42.54931 ? 393 GLN   B O   1 
ATOM   5049 C  CB  . GLN   B 1 393 ? -22.30557 13.73373  80.48121 1.000 43.49826 ? 393 GLN   B CB  1 
ATOM   5050 C  CG  . GLN   B 1 393 ? -21.08723 14.08951  81.31511 1.000 44.17368 ? 393 GLN   B CG  1 
ATOM   5051 C  CD  . GLN   B 1 393 ? -19.96554 14.67332  80.47773 1.000 53.33773 ? 393 GLN   B CD  1 
ATOM   5052 O  OE1 . GLN   B 1 393 ? -20.07287 15.78950  79.96898 1.000 57.35191 ? 393 GLN   B OE1 1 
ATOM   5053 N  NE2 . GLN   B 1 393 ? -18.88548 13.91650  80.32246 1.000 51.75104 ? 393 GLN   B NE2 1 
ATOM   5054 N  N   . ASP   B 1 394 ? -23.45914 10.82536  80.73438 1.000 34.25460 ? 394 ASP   B N   1 
ATOM   5055 C  CA  . ASP   B 1 394 ? -23.66463 9.59500   81.49614 1.000 37.93484 ? 394 ASP   B CA  1 
ATOM   5056 C  C   . ASP   B 1 394 ? -23.03583 8.39217   80.80673 1.000 42.18404 ? 394 ASP   B C   1 
ATOM   5057 O  O   . ASP   B 1 394 ? -22.58992 7.45312   81.47659 1.000 37.53913 ? 394 ASP   B O   1 
ATOM   5058 C  CB  . ASP   B 1 394 ? -25.15853 9.34714   81.71081 1.000 36.90880 ? 394 ASP   B CB  1 
ATOM   5059 C  CG  . ASP   B 1 394 ? -25.74535 10.21694  82.80171 1.000 48.20930 ? 394 ASP   B CG  1 
ATOM   5060 O  OD1 . ASP   B 1 394 ? -25.18734 11.30323  83.06512 1.000 36.69244 ? 394 ASP   B OD1 1 
ATOM   5061 O  OD2 . ASP   B 1 394 ? -26.76685 9.81118   83.39582 1.000 36.25706 ? 394 ASP   B OD2 1 
ATOM   5062 N  N   . ILE   B 1 395 ? -22.98551 8.40663   79.47580 1.000 41.41907 ? 395 ILE   B N   1 
ATOM   5063 C  CA  . ILE   B 1 395 ? -22.42122 7.28935   78.72979 1.000 34.86917 ? 395 ILE   B CA  1 
ATOM   5064 C  C   . ILE   B 1 395 ? -20.90331 7.39703   78.65634 1.000 35.52995 ? 395 ILE   B C   1 
ATOM   5065 O  O   . ILE   B 1 395 ? -20.19054 6.40785   78.86233 1.000 37.48198 ? 395 ILE   B O   1 
ATOM   5066 C  CB  . ILE   B 1 395 ? -23.06647 7.22670   77.33454 1.000 36.15720 ? 395 ILE   B CB  1 
ATOM   5067 C  CG1 . ILE   B 1 395 ? -24.56019 6.92129   77.46448 1.000 32.40344 ? 395 ILE   B CG1 1 
ATOM   5068 C  CG2 . ILE   B 1 395 ? -22.37547 6.19509   76.46951 1.000 29.93790 ? 395 ILE   B CG2 1 
ATOM   5069 C  CD1 . ILE   B 1 395 ? -25.30275 6.92284   76.15106 1.000 35.40849 ? 395 ILE   B CD1 1 
ATOM   5070 N  N   . LEU   B 1 396 ? -20.38363 8.59423   78.37003 1.000 32.54651 ? 396 LEU   B N   1 
ATOM   5071 C  CA  . LEU   B 1 396 ? -18.93754 8.79208   78.37378 1.000 32.95216 ? 396 LEU   B CA  1 
ATOM   5072 C  C   . LEU   B 1 396 ? -18.35003 8.57895   79.76384 1.000 41.57165 ? 396 LEU   B C   1 
ATOM   5073 O  O   . LEU   B 1 396 ? -17.19125 8.16614   79.89128 1.000 35.95482 ? 396 LEU   B O   1 
ATOM   5074 C  CB  . LEU   B 1 396 ? -18.59861 10.19184  77.85731 1.000 37.62776 ? 396 LEU   B CB  1 
ATOM   5075 C  CG  . LEU   B 1 396 ? -17.12879 10.49855  77.56252 1.000 41.93048 ? 396 LEU   B CG  1 
ATOM   5076 C  CD1 . LEU   B 1 396 ? -16.60860 9.60584   76.44696 1.000 37.29113 ? 396 LEU   B CD1 1 
ATOM   5077 C  CD2 . LEU   B 1 396 ? -16.94682 11.96633  77.20685 1.000 32.69053 ? 396 LEU   B CD2 1 
ATOM   5078 N  N   . ASP   B 1 397 ? -19.13017 8.85366   80.81255 1.000 43.99789 ? 397 ASP   B N   1 
ATOM   5079 C  CA  . ASP   B 1 397 ? -18.68606 8.57595   82.17549 1.000 41.54909 ? 397 ASP   B CA  1 
ATOM   5080 C  C   . ASP   B 1 397 ? -18.49575 7.08020   82.39181 1.000 35.13069 ? 397 ASP   B C   1 
ATOM   5081 O  O   . ASP   B 1 397 ? -17.41308 6.62502   82.77902 1.000 35.39066 ? 397 ASP   B O   1 
ATOM   5082 C  CB  . ASP   B 1 397 ? -19.69730 9.12874   83.18178 1.000 41.27671 ? 397 ASP   B CB  1 
ATOM   5083 C  CG  . ASP   B 1 397 ? -19.69084 10.63880  83.24951 1.000 41.47360 ? 397 ASP   B CG  1 
ATOM   5084 O  OD1 . ASP   B 1 397 ? -18.67809 11.25209  82.85428 1.000 36.77876 ? 397 ASP   B OD1 1 
ATOM   5085 O  OD2 . ASP   B 1 397 ? -20.70671 11.21184  83.69489 1.000 38.94334 ? 397 ASP   B OD2 1 
ATOM   5086 N  N   . THR   B 1 398 ? -19.55694 6.30159   82.15485 1.000 37.39822 ? 398 THR   B N   1 
ATOM   5087 C  CA  . THR   B 1 398 ? -19.50258 4.85626   82.35513 1.000 34.69118 ? 398 THR   B CA  1 
ATOM   5088 C  C   . THR   B 1 398 ? -18.35918 4.22884   81.57021 1.000 35.58287 ? 398 THR   B C   1 
ATOM   5089 O  O   . THR   B 1 398 ? -17.67230 3.32878   82.06787 1.000 35.12548 ? 398 THR   B O   1 
ATOM   5090 C  CB  . THR   B 1 398 ? -20.83417 4.22359   81.94481 1.000 35.88356 ? 398 THR   B CB  1 
ATOM   5091 O  OG1 . THR   B 1 398 ? -21.91753 4.97367   82.50871 1.000 40.09514 ? 398 THR   B OG1 1 
ATOM   5092 C  CG2 . THR   B 1 398 ? -20.91572 2.78382   82.42956 1.000 30.79932 ? 398 THR   B CG2 1 
ATOM   5093 N  N   . LEU   B 1 399 ? -18.14060 4.69676   80.33929 1.000 31.04040 ? 399 LEU   B N   1 
ATOM   5094 C  CA  . LEU   B 1 399 ? -17.03678 4.19214   79.52935 1.000 33.40326 ? 399 LEU   B CA  1 
ATOM   5095 C  C   . LEU   B 1 399 ? -15.70044 4.39815   80.23224 1.000 34.01230 ? 399 LEU   B C   1 
ATOM   5096 O  O   . LEU   B 1 399 ? -14.88470 3.47342   80.32563 1.000 31.07120 ? 399 LEU   B O   1 
ATOM   5097 C  CB  . LEU   B 1 399 ? -17.04287 4.87909   78.16359 1.000 27.63789 ? 399 LEU   B CB  1 
ATOM   5098 C  CG  . LEU   B 1 399 ? -15.83362 4.64678   77.25727 1.000 30.96099 ? 399 LEU   B CG  1 
ATOM   5099 C  CD1 . LEU   B 1 399 ? -15.61264 3.16150   77.01597 1.000 25.55438 ? 399 LEU   B CD1 1 
ATOM   5100 C  CD2 . LEU   B 1 399 ? -16.01259 5.38534   75.94122 1.000 23.90104 ? 399 LEU   B CD2 1 
ATOM   5101 N  N   . GLU   B 1 400 ? -15.46099 5.60945   80.73943 1.000 30.79313 ? 400 GLU   B N   1 
ATOM   5102 C  CA  . GLU   B 1 400 ? -14.20884 5.87998   81.43617 1.000 31.12838 ? 400 GLU   B CA  1 
ATOM   5103 C  C   . GLU   B 1 400 ? -14.11857 5.11137   82.74977 1.000 26.80211 ? 400 GLU   B C   1 
ATOM   5104 O  O   . GLU   B 1 400 ? -13.01710 4.73853   83.17046 1.000 28.82645 ? 400 GLU   B O   1 
ATOM   5105 C  CB  . GLU   B 1 400 ? -14.05639 7.38461   81.66317 1.000 36.87173 ? 400 GLU   B CB  1 
ATOM   5106 C  CG  . GLU   B 1 400 ? -13.55171 8.12837   80.43082 1.000 38.22209 ? 400 GLU   B CG  1 
ATOM   5107 C  CD  . GLU   B 1 400 ? -14.01201 9.57304   80.37312 1.000 45.55943 ? 400 GLU   B CD  1 
ATOM   5108 O  OE1 . GLU   B 1 400 ? -13.56814 10.30019  79.45881 1.000 47.02775 ? 400 GLU   B OE1 1 
ATOM   5109 O  OE2 . GLU   B 1 400 ? -14.82158 9.97978   81.23272 1.000 42.18425 ? 400 GLU   B OE2 1 
ATOM   5110 N  N   . ASP   B 1 401 ? -15.25597 4.85523   83.40284 1.000 26.87925 ? 401 ASP   B N   1 
ATOM   5111 C  CA  . ASP   B 1 401 ? -15.25584 3.98841   84.57856 1.000 29.47815 ? 401 ASP   B CA  1 
ATOM   5112 C  C   . ASP   B 1 401 ? -14.83008 2.57397   84.21238 1.000 31.45050 ? 401 ASP   B C   1 
ATOM   5113 O  O   . ASP   B 1 401 ? -13.93917 1.99493   84.84538 1.000 26.98595 ? 401 ASP   B O   1 
ATOM   5114 C  CB  . ASP   B 1 401 ? -16.64125 3.96200   85.22496 1.000 26.31269 ? 401 ASP   B CB  1 
ATOM   5115 C  CG  . ASP   B 1 401 ? -16.99847 5.26511   85.88878 1.000 32.40878 ? 401 ASP   B CG  1 
ATOM   5116 O  OD1 . ASP   B 1 401 ? -16.12154 6.14548   85.95543 1.000 21.50009 ? 401 ASP   B OD1 1 
ATOM   5117 O  OD2 . ASP   B 1 401 ? -18.14922 5.40438   86.35320 1.000 28.86599 ? 401 ASP   B OD2 1 
ATOM   5118 N  N   . ASN   B 1 402 ? -15.47112 1.99704   83.19281 1.000 31.24988 ? 402 ASN   B N   1 
ATOM   5119 C  CA  . ASN   B 1 402 ? -15.16938 0.62525   82.80240 1.000 28.23990 ? 402 ASN   B CA  1 
ATOM   5120 C  C   . ASN   B 1 402 ? -13.74574 0.48998   82.28217 1.000 26.36204 ? 402 ASN   B C   1 
ATOM   5121 O  O   . ASN   B 1 402 ? -13.13065 -0.57202  82.43264 1.000 28.18093 ? 402 ASN   B O   1 
ATOM   5122 C  CB  . ASN   B 1 402 ? -16.17360 0.15259   81.75233 1.000 24.35319 ? 402 ASN   B CB  1 
ATOM   5123 C  CG  . ASN   B 1 402 ? -17.58095 0.03972   82.30475 1.000 27.83285 ? 402 ASN   B CG  1 
ATOM   5124 O  OD1 . ASN   B 1 402 ? -17.78036 -0.01630  83.51871 1.000 33.61258 ? 402 ASN   B OD1 1 
ATOM   5125 N  ND2 . ASN   B 1 402 ? -18.56613 0.00950   81.41520 1.000 27.68344 ? 402 ASN   B ND2 1 
ATOM   5126 N  N   . ARG   B 1 403 ? -13.20840 1.54828   81.67274 1.000 23.82404 ? 403 ARG   B N   1 
ATOM   5127 C  CA  . ARG   B 1 403 ? -11.81045 1.53131   81.25965 1.000 22.57626 ? 403 ARG   B CA  1 
ATOM   5128 C  C   . ARG   B 1 403 ? -10.88584 1.53174   82.47062 1.000 28.61041 ? 403 ARG   B C   1 
ATOM   5129 O  O   . ARG   B 1 403 ? -9.85581  0.84709   82.47303 1.000 23.47374 ? 403 ARG   B O   1 
ATOM   5130 C  CB  . ARG   B 1 403 ? -11.52451 2.72814   80.35090 1.000 22.23859 ? 403 ARG   B CB  1 
ATOM   5131 C  CG  . ARG   B 1 403 ? -10.17053 2.70445   79.66038 1.000 25.00054 ? 403 ARG   B CG  1 
ATOM   5132 C  CD  . ARG   B 1 403 ? -9.12443  3.47263   80.44561 1.000 20.61264 ? 403 ARG   B CD  1 
ATOM   5133 N  NE  . ARG   B 1 403 ? -7.89398  3.63588   79.68074 1.000 26.41679 ? 403 ARG   B NE  1 
ATOM   5134 C  CZ  . ARG   B 1 403 ? -6.68418  3.71572   80.22211 1.000 25.26496 ? 403 ARG   B CZ  1 
ATOM   5135 N  NH1 . ARG   B 1 403 ? -6.53606  3.63499   81.53719 1.000 26.04502 ? 403 ARG   B NH1 1 
ATOM   5136 N  NH2 . ARG   B 1 403 ? -5.62043  3.86348   79.44483 1.000 22.82280 ? 403 ARG   B NH2 1 
ATOM   5137 N  N   . GLU   B 1 404 ? -11.23719 2.29489   83.50944 1.000 27.47412 ? 404 GLU   B N   1 
ATOM   5138 C  CA  . GLU   B 1 404 ? -10.43877 2.29015   84.73081 1.000 27.38763 ? 404 GLU   B CA  1 
ATOM   5139 C  C   . GLU   B 1 404 ? -10.48010 0.92748   85.40901 1.000 16.89097 ? 404 GLU   B C   1 
ATOM   5140 O  O   . GLU   B 1 404 ? -9.46245  0.45298   85.92705 1.000 23.33848 ? 404 GLU   B O   1 
ATOM   5141 C  CB  . GLU   B 1 404 ? -10.92629 3.37798   85.68942 1.000 24.94331 ? 404 GLU   B CB  1 
ATOM   5142 C  CG  . GLU   B 1 404 ? -10.22992 3.35936   87.04509 1.000 26.52080 ? 404 GLU   B CG  1 
ATOM   5143 C  CD  . GLU   B 1 404 ? -10.60290 4.54245   87.91799 1.000 34.51809 ? 404 GLU   B CD  1 
ATOM   5144 O  OE1 . GLU   B 1 404 ? -11.81119 4.75815   88.14928 1.000 22.56544 ? 404 GLU   B OE1 1 
ATOM   5145 O  OE2 . GLU   B 1 404 ? -9.68491  5.25706   88.37303 1.000 38.27214 ? 404 GLU   B OE2 1 
ATOM   5146 N  N   . TRP   B 1 405 ? -11.64683 0.27949   85.41406 1.000 18.38964 ? 405 TRP   B N   1 
ATOM   5147 C  CA  . TRP   B 1 405 ? -11.75354 -1.02581  86.05626 1.000 20.78324 ? 405 TRP   B CA  1 
ATOM   5148 C  C   . TRP   B 1 405 ? -10.91889 -2.06940  85.32577 1.000 18.80373 ? 405 TRP   B C   1 
ATOM   5149 O  O   . TRP   B 1 405 ? -10.15992 -2.81886  85.95154 1.000 17.39673 ? 405 TRP   B O   1 
ATOM   5150 C  CB  . TRP   B 1 405 ? -13.21145 -1.47313  86.12959 1.000 21.22582 ? 405 TRP   B CB  1 
ATOM   5151 C  CG  . TRP   B 1 405 ? -13.35157 -2.78113  86.83784 1.000 21.68222 ? 405 TRP   B CG  1 
ATOM   5152 C  CD1 . TRP   B 1 405 ? -13.46118 -2.97435  88.18361 1.000 23.18110 ? 405 TRP   B CD1 1 
ATOM   5153 C  CD2 . TRP   B 1 405 ? -13.36347 -4.08506  86.24268 1.000 21.83023 ? 405 TRP   B CD2 1 
ATOM   5154 N  NE1 . TRP   B 1 405 ? -13.55548 -4.31587  88.46329 1.000 21.72352 ? 405 TRP   B NE1 1 
ATOM   5155 C  CE2 . TRP   B 1 405 ? -13.49761 -5.01950  87.28896 1.000 21.34743 ? 405 TRP   B CE2 1 
ATOM   5156 C  CE3 . TRP   B 1 405 ? -13.28172 -4.55239  84.92702 1.000 20.45452 ? 405 TRP   B CE3 1 
ATOM   5157 C  CZ2 . TRP   B 1 405 ? -13.55209 -6.39339  87.06101 1.000 19.84756 ? 405 TRP   B CZ2 1 
ATOM   5158 C  CZ3 . TRP   B 1 405 ? -13.33647 -5.91812  84.70259 1.000 22.84305 ? 405 TRP   B CZ3 1 
ATOM   5159 C  CH2 . TRP   B 1 405 ? -13.47038 -6.82156  85.76453 1.000 17.35292 ? 405 TRP   B CH2 1 
ATOM   5160 N  N   . TYR   B 1 406 ? -11.05406 -2.14091  83.99890 1.000 17.89664 ? 406 TYR   B N   1 
ATOM   5161 C  CA  . TYR   B 1 406 ? -10.28598 -3.11897  83.23553 1.000 15.82141 ? 406 TYR   B CA  1 
ATOM   5162 C  C   . TYR   B 1 406 ? -8.78938  -2.87678  83.37735 1.000 22.49429 ? 406 TYR   B C   1 
ATOM   5163 O  O   . TYR   B 1 406 ? -8.00362  -3.82929  83.44884 1.000 19.08231 ? 406 TYR   B O   1 
ATOM   5164 C  CB  . TYR   B 1 406 ? -10.70136 -3.08866  81.76535 1.000 17.42310 ? 406 TYR   B CB  1 
ATOM   5165 C  CG  . TYR   B 1 406 ? -11.65692 -4.19488  81.38081 1.000 18.99855 ? 406 TYR   B CG  1 
ATOM   5166 C  CD1 . TYR   B 1 406 ? -11.20701 -5.49865  81.21567 1.000 18.01317 ? 406 TYR   B CD1 1 
ATOM   5167 C  CD2 . TYR   B 1 406 ? -13.00621 -3.93708  81.17996 1.000 20.07571 ? 406 TYR   B CD2 1 
ATOM   5168 C  CE1 . TYR   B 1 406 ? -12.07415 -6.51553  80.86453 1.000 18.69253 ? 406 TYR   B CE1 1 
ATOM   5169 C  CE2 . TYR   B 1 406 ? -13.88155 -4.94871  80.82862 1.000 19.42871 ? 406 TYR   B CE2 1 
ATOM   5170 C  CZ  . TYR   B 1 406 ? -13.40931 -6.23519  80.67130 1.000 18.33742 ? 406 TYR   B CZ  1 
ATOM   5171 O  OH  . TYR   B 1 406 ? -14.27439 -7.24572  80.32074 1.000 18.31570 ? 406 TYR   B OH  1 
ATOM   5172 N  N   . GLN   B 1 407 ? -8.37497  -1.60826  83.42547 1.000 16.50889 ? 407 GLN   B N   1 
ATOM   5173 C  CA  . GLN   B 1 407 ? -6.96844  -1.30772  83.66898 1.000 20.87233 ? 407 GLN   B CA  1 
ATOM   5174 C  C   . GLN   B 1 407 ? -6.53120  -1.81079  85.03875 1.000 17.66844 ? 407 GLN   B C   1 
ATOM   5175 O  O   . GLN   B 1 407 ? -5.40124  -2.28608  85.20317 1.000 21.74273 ? 407 GLN   B O   1 
ATOM   5176 C  CB  . GLN   B 1 407 ? -6.71886  0.19526   83.54470 1.000 21.32243 ? 407 GLN   B CB  1 
ATOM   5177 C  CG  . GLN   B 1 407 ? -5.26842  0.59865   83.76452 1.000 21.22000 ? 407 GLN   B CG  1 
ATOM   5178 C  CD  . GLN   B 1 407 ? -4.33297  0.00728   82.72600 1.000 29.23046 ? 407 GLN   B CD  1 
ATOM   5179 O  OE1 . GLN   B 1 407 ? -4.63523  0.00325   81.53244 1.000 26.63514 ? 407 GLN   B OE1 1 
ATOM   5180 N  NE2 . GLN   B 1 407 ? -3.19104  -0.50029  83.17736 1.000 20.95951 ? 407 GLN   B NE2 1 
ATOM   5181 N  N   . SER   B 1 408 ? -7.41813  -1.72767  86.03332 1.000 17.34470 ? 408 SER   B N   1 
ATOM   5182 C  CA  . SER   B 1 408 ? -7.07339  -2.19462  87.36999 1.000 21.98657 ? 408 SER   B CA  1 
ATOM   5183 C  C   . SER   B 1 408 ? -6.93040  -3.70923  87.43741 1.000 21.09159 ? 408 SER   B C   1 
ATOM   5184 O  O   . SER   B 1 408 ? -6.26833  -4.21462  88.34941 1.000 19.48431 ? 408 SER   B O   1 
ATOM   5185 C  CB  . SER   B 1 408 ? -8.11996  -1.72607  88.38085 1.000 17.51392 ? 408 SER   B CB  1 
ATOM   5186 O  OG  . SER   B 1 408 ? -9.30612  -2.49535  88.29377 1.000 18.96887 ? 408 SER   B OG  1 
ATOM   5187 N  N   . THR   B 1 409 ? -7.53079  -4.44411  86.50065 1.000 15.51583 ? 409 THR   B N   1 
ATOM   5188 C  CA  . THR   B 1 409 ? -7.34712  -5.88863  86.45411 1.000 17.86504 ? 409 THR   B CA  1 
ATOM   5189 C  C   . THR   B 1 409 ? -5.98184  -6.29107  85.91263 1.000 19.41495 ? 409 THR   B C   1 
ATOM   5190 O  O   . THR   B 1 409 ? -5.66039  -7.48410  85.91501 1.000 20.17128 ? 409 THR   B O   1 
ATOM   5191 C  CB  . THR   B 1 409 ? -8.44269  -6.53996  85.60502 1.000 19.39727 ? 409 THR   B CB  1 
ATOM   5192 O  OG1 . THR   B 1 409 ? -8.40116  -6.00765  84.27552 1.000 25.03930 ? 409 THR   B OG1 1 
ATOM   5193 C  CG2 . THR   B 1 409 ? -9.81425  -6.27890  86.21045 1.000 17.85764 ? 409 THR   B CG2 1 
ATOM   5194 N  N   . ILE   B 1 410 ? -5.18150  -5.33640  85.45589 1.000 18.66700 ? 410 ILE   B N   1 
ATOM   5195 C  CA  . ILE   B 1 410 ? -3.84613  -5.59699  84.92611 1.000 25.94397 ? 410 ILE   B CA  1 
ATOM   5196 C  C   . ILE   B 1 410 ? -2.83805  -5.30118  86.03140 1.000 25.01713 ? 410 ILE   B C   1 
ATOM   5197 O  O   . ILE   B 1 410 ? -2.76323  -4.15055  86.48965 1.000 20.66176 ? 410 ILE   B O   1 
ATOM   5198 C  CB  . ILE   B 1 410 ? -3.56040  -4.74535  83.68061 1.000 20.06292 ? 410 ILE   B CB  1 
ATOM   5199 C  CG1 . ILE   B 1 410 ? -4.61450  -5.00937  82.60297 1.000 22.67376 ? 410 ILE   B CG1 1 
ATOM   5200 C  CG2 . ILE   B 1 410 ? -2.15909  -5.02096  83.15253 1.000 19.64486 ? 410 ILE   B CG2 1 
ATOM   5201 C  CD1 . ILE   B 1 410 ? -4.72305  -3.90634  81.57333 1.000 20.90411 ? 410 ILE   B CD1 1 
ATOM   5202 N  N   . PRO   B 1 411 ? -2.05399  -6.29003  86.48818 1.000 24.08571 ? 411 PRO   B N   1 
ATOM   5203 C  CA  . PRO   B 1 411 ? -1.06427  -6.10455  87.55659 1.000 23.10796 ? 411 PRO   B CA  1 
ATOM   5204 C  C   . PRO   B 1 411 ? -0.01305  -5.05282  87.21258 1.000 33.35580 ? 411 PRO   B C   1 
ATOM   5205 O  O   . PRO   B 1 411 ? 0.54412   -5.10397  86.11609 1.000 29.35959 ? 411 PRO   B O   1 
ATOM   5206 C  CB  . PRO   B 1 411 ? -0.42064  -7.49013  87.68510 1.000 23.57723 ? 411 PRO   B CB  1 
ATOM   5207 C  CG  . PRO   B 1 411 ? -1.42431  -8.43550  87.11439 1.000 27.63822 ? 411 PRO   B CG  1 
ATOM   5208 C  CD  . PRO   B 1 411 ? -2.09284  -7.68176  86.00853 1.000 28.13243 ? 411 PRO   B CD  1 
HETATM 5209 ZN ZN  . ZN    C 2 .   ? -19.16299 -3.45765  28.62937 1.000 17.92922 ? 601 ZN    A ZN  1 
HETATM 5210 MG MG  . MG    D 3 .   ? -20.69766 -3.52636  31.94177 1.000 8.95395  ? 602 MG    A MG  1 
HETATM 5211 C  C4  . A1D8Q E 4 .   ? -21.80820 0.81302   29.34925 1.000 13.74831 ? 603 A1D8Q A C4  1 
HETATM 5212 C  C5  . A1D8Q E 4 .   ? -23.02122 1.33996   28.92147 1.000 17.17865 ? 603 A1D8Q A C5  1 
HETATM 5213 C  C6  . A1D8Q E 4 .   ? -24.01655 1.59871   29.88595 1.000 25.41607 ? 603 A1D8Q A C6  1 
HETATM 5214 C  C3  . A1D8Q E 4 .   ? -21.59000 0.55066   30.69268 1.000 17.68695 ? 603 A1D8Q A C3  1 
HETATM 5215 C  C2  . A1D8Q E 4 .   ? -22.58588 0.81350   31.63043 1.000 19.27496 ? 603 A1D8Q A C2  1 
HETATM 5216 C  C1  . A1D8Q E 4 .   ? -23.81050 1.33966   31.23687 1.000 16.56858 ? 603 A1D8Q A C1  1 
HETATM 5217 C  C7  . A1D8Q E 4 .   ? -23.57508 1.73385   27.63376 1.000 21.52010 ? 603 A1D8Q A C7  1 
HETATM 5218 C  C8  . A1D8Q E 4 .   ? -24.95821 2.23732   27.92774 1.000 21.62158 ? 603 A1D8Q A C8  1 
HETATM 5219 N  N9  . A1D8Q E 4 .   ? -25.14095 2.12552   29.26472 1.000 17.64872 ? 603 A1D8Q A N9  1 
HETATM 5220 O  O10 . A1D8Q E 4 .   ? -25.78464 2.67337   27.12922 1.000 26.45544 ? 603 A1D8Q A O10 1 
HETATM 5221 C  C11 . A1D8Q E 4 .   ? -22.89390 1.60708   26.47938 1.000 18.76375 ? 603 A1D8Q A C11 1 
HETATM 5222 O  O12 . A1D8Q E 4 .   ? -22.35356 0.57155   32.95358 1.000 17.97845 ? 603 A1D8Q A O12 1 
HETATM 5223 C  C13 . A1D8Q E 4 .   ? -23.19105 1.98492   25.09258 1.000 15.27055 ? 603 A1D8Q A C13 1 
HETATM 5224 C  C14 . A1D8Q E 4 .   ? -24.25486 2.80689   24.70907 1.000 17.19125 ? 603 A1D8Q A C14 1 
HETATM 5225 C  C15 . A1D8Q E 4 .   ? -24.43668 3.15087   23.38085 1.000 19.91731 ? 603 A1D8Q A C15 1 
HETATM 5226 C  C16 . A1D8Q E 4 .   ? -23.54446 2.66836   22.40397 1.000 13.76020 ? 603 A1D8Q A C16 1 
HETATM 5227 C  C17 . A1D8Q E 4 .   ? -22.48867 1.85197   22.77921 1.000 13.77284 ? 603 A1D8Q A C17 1 
HETATM 5228 C  C18 . A1D8Q E 4 .   ? -22.31974 1.51718   24.11082 1.000 15.90061 ? 603 A1D8Q A C18 1 
HETATM 5229 O  O19 . A1D8Q E 4 .   ? -23.79553 3.05943   21.11015 1.000 17.64221 ? 603 A1D8Q A O19 1 
HETATM 5230 O  O20 . A1D8Q E 4 .   ? -25.45540 3.95363   22.92620 1.000 18.40236 ? 603 A1D8Q A O20 1 
HETATM 5231 C  C21 . A1D8Q E 4 .   ? -22.97205 2.69556   20.08552 1.000 15.95704 ? 603 A1D8Q A C21 1 
HETATM 5232 F  F22 . A1D8Q E 4 .   ? -21.72767 3.18017   20.23681 1.000 18.53461 ? 603 A1D8Q A F22 1 
HETATM 5233 F  F23 . A1D8Q E 4 .   ? -22.95730 1.36442   19.89986 1.000 14.80291 ? 603 A1D8Q A F23 1 
HETATM 5234 C  C24 . A1D8Q E 4 .   ? -26.57269 4.23370   23.81658 1.000 24.05730 ? 603 A1D8Q A C24 1 
HETATM 5235 C  C25 . A1D8Q E 4 .   ? -26.31000 5.43899   24.70823 1.000 18.85870 ? 603 A1D8Q A C25 1 
HETATM 5236 C  C26 . A1D8Q E 4 .   ? -26.94014 6.62752   24.00490 1.000 24.56921 ? 603 A1D8Q A C26 1 
HETATM 5237 C  C27 . A1D8Q E 4 .   ? -27.85169 6.08379   22.91948 1.000 25.92204 ? 603 A1D8Q A C27 1 
HETATM 5238 C  C28 . A1D8Q E 4 .   ? -27.81490 4.56712   23.00859 1.000 17.47594 ? 603 A1D8Q A C28 1 
HETATM 5239 ZN ZN  . ZN    F 2 .   ? -22.70133 -5.76578  65.11920 1.000 20.66922 ? 601 ZN    B ZN  1 
HETATM 5240 MG MG  . MG    G 3 .   ? -21.39593 -6.44172  61.82472 1.000 10.62223 ? 602 MG    B MG  1 
HETATM 5241 C  C4  . A1D8Q H 4 .   ? -17.89445 -4.70140  65.05737 1.000 26.32495 ? 603 A1D8Q B C4  1 
HETATM 5242 C  C5  . A1D8Q H 4 .   ? -16.76968 -5.40233  65.47495 1.000 29.36560 ? 603 A1D8Q B C5  1 
HETATM 5243 C  C6  . A1D8Q H 4 .   ? -15.87616 -5.88092  64.49529 1.000 28.20748 ? 603 A1D8Q B C6  1 
HETATM 5244 C  C3  . A1D8Q H 4 .   ? -18.12584 -4.48181  63.70835 1.000 22.17474 ? 603 A1D8Q B C3  1 
HETATM 5245 C  C2  . A1D8Q H 4 .   ? -17.23107 -4.96191  62.75514 1.000 25.85489 ? 603 A1D8Q B C2  1 
HETATM 5246 C  C1  . A1D8Q H 4 .   ? -16.09714 -5.66767  63.13840 1.000 23.42903 ? 603 A1D8Q B C1  1 
HETATM 5247 C  C7  . A1D8Q H 4 .   ? -16.22271 -5.79897  66.76645 1.000 27.19190 ? 603 A1D8Q B C7  1 
HETATM 5248 C  C8  . A1D8Q H 4 .   ? -14.95545 -6.53756  66.45562 1.000 33.84556 ? 603 A1D8Q B C8  1 
HETATM 5249 N  N9  . A1D8Q H 4 .   ? -14.82116 -6.54344  65.10859 1.000 30.87856 ? 603 A1D8Q B N9  1 
HETATM 5250 O  O10 . A1D8Q H 4 .   ? -14.17508 -7.05666  67.25201 1.000 37.20404 ? 603 A1D8Q B O10 1 
HETATM 5251 C  C11 . A1D8Q H 4 .   ? -16.79749 -5.54087  67.95526 1.000 28.31195 ? 603 A1D8Q B C11 1 
HETATM 5252 O  O12 . A1D8Q H 4 .   ? -17.45638 -4.72277  61.42982 1.000 27.45208 ? 603 A1D8Q B O12 1 
HETATM 5253 C  C13 . A1D8Q H 4 .   ? -16.37587 -5.77064  69.34219 1.000 26.32635 ? 603 A1D8Q B C13 1 
HETATM 5254 C  C14 . A1D8Q H 4 .   ? -15.06189 -6.00552  69.76195 1.000 23.86073 ? 603 A1D8Q B C14 1 
HETATM 5255 C  C15 . A1D8Q H 4 .   ? -14.76731 -6.14042  71.10813 1.000 24.96609 ? 603 A1D8Q B C15 1 
HETATM 5256 C  C16 . A1D8Q H 4 .   ? -15.79548 -6.04241  72.06344 1.000 20.57093 ? 603 A1D8Q B C16 1 
HETATM 5257 C  C17 . A1D8Q H 4 .   ? -17.09883 -5.81170  71.65238 1.000 20.80087 ? 603 A1D8Q B C17 1 
HETATM 5258 C  C18 . A1D8Q H 4 .   ? -17.37922 -5.67898  70.30450 1.000 23.48472 ? 603 A1D8Q B C18 1 
HETATM 5259 O  O19 . A1D8Q H 4 .   ? -15.40679 -6.17878  73.37426 1.000 23.96931 ? 603 A1D8Q B O19 1 
HETATM 5260 O  O20 . A1D8Q H 4 .   ? -13.51365 -6.38109  71.61592 1.000 22.68839 ? 603 A1D8Q B O20 1 
HETATM 5261 C  C21 . A1D8Q H 4 .   ? -16.29115 -6.00004  74.39178 1.000 23.49347 ? 603 A1D8Q B C21 1 
HETATM 5262 F  F22 . A1D8Q H 4 .   ? -16.75959 -4.73983  74.41745 1.000 25.97778 ? 603 A1D8Q B F22 1 
HETATM 5263 F  F23 . A1D8Q H 4 .   ? -17.26765 -6.92283  74.34838 1.000 21.85668 ? 603 A1D8Q B F23 1 
HETATM 5264 C  C24 . A1D8Q H 4 .   ? -12.49271 -6.91819  70.73474 1.000 27.43823 ? 603 A1D8Q B C24 1 
HETATM 5265 C  C25 . A1D8Q H 4 .   ? -11.62420 -5.77738  70.22242 1.000 27.61996 ? 603 A1D8Q B C25 1 
HETATM 5266 C  C26 . A1D8Q H 4 .   ? -10.34982 -5.80278  71.05396 1.000 29.56671 ? 603 A1D8Q B C26 1 
HETATM 5267 C  C27 . A1D8Q H 4 .   ? -10.51784 -6.88839  72.08564 1.000 27.40109 ? 603 A1D8Q B C27 1 
HETATM 5268 C  C28 . A1D8Q H 4 .   ? -11.57715 -7.82504  71.54157 1.000 28.85587 ? 603 A1D8Q B C28 1 
HETATM 5269 O  O   . HOH   I 5 .   ? 3.73336   -17.64368 38.43717 1.000 35.92632 ? 701 HOH   A O   1 
HETATM 5270 O  O   . HOH   I 5 .   ? -27.18904 -12.15851 20.51437 1.000 18.50274 ? 702 HOH   A O   1 
HETATM 5271 O  O   . HOH   I 5 .   ? -3.281    24.946    33.915   1.000 30.70789 ? 703 HOH   A O   1 
HETATM 5272 O  O   . HOH   I 5 .   ? 3.03896   -0.70575  29.77700 1.000 24.38463 ? 704 HOH   A O   1 
HETATM 5273 O  O   . HOH   I 5 .   ? -5.62508  -27.20451 35.68392 1.000 22.60486 ? 705 HOH   A O   1 
HETATM 5274 O  O   . HOH   I 5 .   ? -12.85908 -3.99698  16.41934 1.000 17.67544 ? 706 HOH   A O   1 
HETATM 5275 O  O   . HOH   I 5 .   ? -15.22674 -0.90799  20.12397 1.000 12.89002 ? 707 HOH   A O   1 
HETATM 5276 O  O   . HOH   I 5 .   ? 2.21638   8.73662   40.12419 1.000 28.89689 ? 708 HOH   A O   1 
HETATM 5277 O  O   . HOH   I 5 .   ? 0.10032   -25.56214 39.64840 1.000 27.19231 ? 709 HOH   A O   1 
HETATM 5278 O  O   . HOH   I 5 .   ? -28.92005 1.72271   14.59633 1.000 22.60994 ? 710 HOH   A O   1 
HETATM 5279 O  O   . HOH   I 5 .   ? -39.71462 -0.21382  23.26734 1.000 36.74645 ? 711 HOH   A O   1 
HETATM 5280 O  O   . HOH   I 5 .   ? -18.32354 16.23166  20.51811 1.000 22.08583 ? 712 HOH   A O   1 
HETATM 5281 O  O   . HOH   I 5 .   ? -24.45248 1.23255   40.38534 1.000 23.40628 ? 713 HOH   A O   1 
HETATM 5282 O  O   . HOH   I 5 .   ? -30.62544 -6.01959  49.16565 1.000 16.78603 ? 714 HOH   A O   1 
HETATM 5283 O  O   . HOH   I 5 .   ? -2.01536  -6.49510  14.07477 1.000 24.02959 ? 715 HOH   A O   1 
HETATM 5284 O  O   . HOH   I 5 .   ? -9.64400  5.41094   40.80539 1.000 24.69528 ? 716 HOH   A O   1 
HETATM 5285 O  O   . HOH   I 5 .   ? -11.94475 -18.04508 41.99070 1.000 21.16584 ? 717 HOH   A O   1 
HETATM 5286 O  O   . HOH   I 5 .   ? -32.86007 -5.66808  26.61823 1.000 25.71052 ? 718 HOH   A O   1 
HETATM 5287 O  O   . HOH   I 5 .   ? -17.96789 -4.74828  45.54931 1.000 16.74933 ? 719 HOH   A O   1 
HETATM 5288 O  O   . HOH   I 5 .   ? -32.34793 1.79013   32.34154 1.000 24.80114 ? 720 HOH   A O   1 
HETATM 5289 O  O   . HOH   I 5 .   ? -7.14100  5.29510   41.77684 1.000 30.41601 ? 721 HOH   A O   1 
HETATM 5290 O  O   . HOH   I 5 .   ? -10.03941 -25.12566 38.67115 1.000 21.84239 ? 722 HOH   A O   1 
HETATM 5291 O  O   . HOH   I 5 .   ? -0.46661  -19.46062 44.53711 1.000 27.30762 ? 723 HOH   A O   1 
HETATM 5292 O  O   . HOH   I 5 .   ? -19.21283 -4.13946  33.36269 1.000 10.95210 ? 724 HOH   A O   1 
HETATM 5293 O  O   . HOH   I 5 .   ? -28.24250 -2.82353  28.19064 1.000 18.73349 ? 725 HOH   A O   1 
HETATM 5294 O  O   . HOH   I 5 .   ? -15.63198 -25.79877 32.02514 1.000 28.51300 ? 726 HOH   A O   1 
HETATM 5295 O  O   . HOH   I 5 .   ? -23.44783 -13.17578 41.55181 1.000 13.12176 ? 727 HOH   A O   1 
HETATM 5296 O  O   . HOH   I 5 .   ? -17.40152 1.43612   31.29519 1.000 10.60583 ? 728 HOH   A O   1 
HETATM 5297 O  O   . HOH   I 5 .   ? 5.39613   -13.13507 44.20882 1.000 25.58708 ? 729 HOH   A O   1 
HETATM 5298 O  O   . HOH   I 5 .   ? -25.24571 1.87372   36.65677 1.000 17.76368 ? 730 HOH   A O   1 
HETATM 5299 O  O   . HOH   I 5 .   ? -27.39096 3.65284   13.78615 1.000 21.69289 ? 731 HOH   A O   1 
HETATM 5300 O  O   . HOH   I 5 .   ? -3.34505  11.32852  21.98624 1.000 20.30953 ? 732 HOH   A O   1 
HETATM 5301 O  O   . HOH   I 5 .   ? -24.26363 -1.00934  33.95575 1.000 17.18194 ? 733 HOH   A O   1 
HETATM 5302 O  O   . HOH   I 5 .   ? 2.24003   11.74682  26.85794 1.000 38.33480 ? 734 HOH   A O   1 
HETATM 5303 O  O   . HOH   I 5 .   ? -31.06799 1.43514   47.41221 1.000 18.29726 ? 735 HOH   A O   1 
HETATM 5304 O  O   . HOH   I 5 .   ? -18.26345 -3.47500  21.79119 1.000 11.04067 ? 736 HOH   A O   1 
HETATM 5305 O  O   . HOH   I 5 .   ? -10.87106 7.75640   39.96387 1.000 24.94410 ? 737 HOH   A O   1 
HETATM 5306 O  O   . HOH   I 5 .   ? -24.16742 -11.75204 28.64850 1.000 14.70216 ? 738 HOH   A O   1 
HETATM 5307 O  O   . HOH   I 5 .   ? -12.20888 -5.48779  18.36738 1.000 13.97382 ? 739 HOH   A O   1 
HETATM 5308 O  O   . HOH   I 5 .   ? -19.50464 -2.75291  30.58191 1.000 9.13837  ? 740 HOH   A O   1 
HETATM 5309 O  O   . HOH   I 5 .   ? -20.75370 -1.74776  33.12149 1.000 10.26553 ? 741 HOH   A O   1 
HETATM 5310 O  O   . HOH   I 5 .   ? -18.50146 13.06484  30.40651 1.000 18.57692 ? 742 HOH   A O   1 
HETATM 5311 O  O   . HOH   I 5 .   ? 5.53281   4.96122   35.32746 1.000 25.69867 ? 743 HOH   A O   1 
HETATM 5312 O  O   . HOH   I 5 .   ? 2.48187   -5.50248  39.70677 1.000 19.06470 ? 744 HOH   A O   1 
HETATM 5313 O  O   . HOH   I 5 .   ? -15.07055 -12.31634 43.62913 1.000 13.08763 ? 745 HOH   A O   1 
HETATM 5314 O  O   . HOH   I 5 .   ? -21.10842 -16.86993 24.03267 1.000 23.58254 ? 746 HOH   A O   1 
HETATM 5315 O  O   . HOH   I 5 .   ? -20.25050 -0.54700  26.07857 1.000 10.62502 ? 747 HOH   A O   1 
HETATM 5316 O  O   . HOH   I 5 .   ? -34.75437 -7.36051  27.58989 1.000 29.46437 ? 748 HOH   A O   1 
HETATM 5317 O  O   . HOH   I 5 .   ? -28.53581 5.81670   11.79335 1.000 21.39844 ? 749 HOH   A O   1 
HETATM 5318 O  O   . HOH   I 5 .   ? -32.16342 10.76130  15.70434 1.000 30.75176 ? 750 HOH   A O   1 
HETATM 5319 O  O   . HOH   I 5 .   ? -17.52615 4.47557   34.57860 1.000 13.03268 ? 751 HOH   A O   1 
HETATM 5320 O  O   . HOH   I 5 .   ? -42.12596 -3.39981  38.31682 1.000 31.54823 ? 752 HOH   A O   1 
HETATM 5321 O  O   . HOH   I 5 .   ? -20.92770 -2.26357  27.89133 1.000 9.92601  ? 753 HOH   A O   1 
HETATM 5322 O  O   . HOH   I 5 .   ? -23.093   19.940    15.161   1.000 25.07788 ? 754 HOH   A O   1 
HETATM 5323 O  O   . HOH   I 5 .   ? -19.36923 9.47231   38.90533 1.000 19.32421 ? 755 HOH   A O   1 
HETATM 5324 O  O   . HOH   I 5 .   ? -24.71607 -2.49626  31.50762 1.000 10.69561 ? 756 HOH   A O   1 
HETATM 5325 O  O   . HOH   I 5 .   ? -10.83728 -2.68473  17.23891 1.000 27.28168 ? 757 HOH   A O   1 
HETATM 5326 O  O   . HOH   I 5 .   ? 2.13874   -3.19180  26.07107 1.000 24.64038 ? 758 HOH   A O   1 
HETATM 5327 O  O   . HOH   I 5 .   ? -3.67756  4.36408   24.91890 1.000 25.53928 ? 759 HOH   A O   1 
HETATM 5328 O  O   . HOH   I 5 .   ? -2.14580  -20.93082 42.90183 1.000 26.28536 ? 760 HOH   A O   1 
HETATM 5329 O  O   . HOH   I 5 .   ? -22.36336 -1.52272  9.39525  1.000 24.03267 ? 761 HOH   A O   1 
HETATM 5330 O  O   . HOH   I 5 .   ? -0.77144  -19.79861 36.19876 1.000 20.49414 ? 762 HOH   A O   1 
HETATM 5331 O  O   . HOH   I 5 .   ? -6.99344  -9.33385  46.90340 1.000 17.74925 ? 763 HOH   A O   1 
HETATM 5332 O  O   . HOH   I 5 .   ? -48.07070 3.07795   33.51194 1.000 38.18037 ? 764 HOH   A O   1 
HETATM 5333 O  O   . HOH   I 5 .   ? -34.80341 -11.65725 39.49363 1.000 26.45035 ? 765 HOH   A O   1 
HETATM 5334 O  O   . HOH   I 5 .   ? -21.35771 9.24190   35.87350 1.000 21.09315 ? 766 HOH   A O   1 
HETATM 5335 O  O   . HOH   I 5 .   ? -26.56887 -0.27758  33.96321 1.000 18.42661 ? 767 HOH   A O   1 
HETATM 5336 O  O   . HOH   I 5 .   ? 3.48725   -17.46759 26.12897 1.000 21.81509 ? 768 HOH   A O   1 
HETATM 5337 O  O   . HOH   I 5 .   ? -19.59224 -23.77745 30.12653 1.000 30.73671 ? 769 HOH   A O   1 
HETATM 5338 O  O   . HOH   I 5 .   ? -23.087   -18.605   25.087   1.000 18.56510 ? 770 HOH   A O   1 
HETATM 5339 O  O   . HOH   I 5 .   ? -33.89519 -3.35592  44.35849 1.000 15.97030 ? 771 HOH   A O   1 
HETATM 5340 O  O   . HOH   I 5 .   ? -9.48050  -7.59554  11.05840 1.000 30.17944 ? 772 HOH   A O   1 
HETATM 5341 O  O   . HOH   I 5 .   ? -19.58559 17.24269  13.85073 1.000 26.20312 ? 773 HOH   A O   1 
HETATM 5342 O  O   . HOH   I 5 .   ? -28.83477 1.79647   35.24985 1.000 16.79574 ? 774 HOH   A O   1 
HETATM 5343 O  O   . HOH   I 5 .   ? -11.84760 -1.60297  10.09974 1.000 26.19664 ? 775 HOH   A O   1 
HETATM 5344 O  O   . HOH   I 5 .   ? -18.74282 1.63482   23.17621 1.000 12.76946 ? 776 HOH   A O   1 
HETATM 5345 O  O   . HOH   I 5 .   ? -22.19466 -4.13824  33.27001 1.000 10.10051 ? 777 HOH   A O   1 
HETATM 5346 O  O   . HOH   I 5 .   ? -24.49199 -17.61393 31.57251 1.000 20.85086 ? 778 HOH   A O   1 
HETATM 5347 O  O   . HOH   I 5 .   ? -7.34362  -25.65386 37.05384 1.000 23.69451 ? 779 HOH   A O   1 
HETATM 5348 O  O   . HOH   I 5 .   ? -15.22919 -2.92601  17.28953 1.000 12.94513 ? 780 HOH   A O   1 
HETATM 5349 O  O   . HOH   I 5 .   ? 4.75411   -15.72340 38.09423 1.000 30.18698 ? 781 HOH   A O   1 
HETATM 5350 O  O   . HOH   I 5 .   ? -14.71472 16.18206  34.21459 1.000 31.84716 ? 782 HOH   A O   1 
HETATM 5351 O  O   . HOH   I 5 .   ? -28.61137 5.64760   19.55783 1.000 20.78456 ? 783 HOH   A O   1 
HETATM 5352 O  O   . HOH   I 5 .   ? -4.58862  7.04518   17.42866 1.000 23.65642 ? 784 HOH   A O   1 
HETATM 5353 O  O   . HOH   I 5 .   ? -23.29123 -14.57680 20.67351 1.000 20.13911 ? 785 HOH   A O   1 
HETATM 5354 O  O   . HOH   I 5 .   ? -26.35075 -0.82113  40.48535 1.000 13.24804 ? 786 HOH   A O   1 
HETATM 5355 O  O   . HOH   I 5 .   ? -4.03190  0.76577   15.43425 1.000 21.55857 ? 787 HOH   A O   1 
HETATM 5356 O  O   . HOH   I 5 .   ? 3.06523   -7.68719  27.29532 1.000 21.16053 ? 788 HOH   A O   1 
HETATM 5357 O  O   . HOH   I 5 .   ? -28.05642 -13.08093 33.60741 1.000 29.35130 ? 789 HOH   A O   1 
HETATM 5358 O  O   . HOH   I 5 .   ? -31.03254 -7.93610  23.11867 1.000 27.30929 ? 790 HOH   A O   1 
HETATM 5359 O  O   . HOH   I 5 .   ? -31.66079 -1.64999  16.05357 1.000 25.40480 ? 791 HOH   A O   1 
HETATM 5360 O  O   . HOH   I 5 .   ? -9.80764  -29.65712 30.19185 1.000 32.34898 ? 792 HOH   A O   1 
HETATM 5361 O  O   . HOH   I 5 .   ? -31.93405 -11.10102 38.90689 1.000 17.38567 ? 793 HOH   A O   1 
HETATM 5362 O  O   . HOH   I 5 .   ? -7.03962  16.86806  18.69770 1.000 31.97363 ? 794 HOH   A O   1 
HETATM 5363 O  O   . HOH   I 5 .   ? 4.60302   -8.85453  36.94873 1.000 22.50079 ? 795 HOH   A O   1 
HETATM 5364 O  O   . HOH   I 5 .   ? -1.73580  4.67527   46.35389 1.000 28.92156 ? 796 HOH   A O   1 
HETATM 5365 O  O   . HOH   I 5 .   ? -1.65156  -4.63916  44.51425 1.000 28.28509 ? 797 HOH   A O   1 
HETATM 5366 O  O   . HOH   I 5 .   ? -22.65645 -9.73464  13.01187 1.000 24.81248 ? 798 HOH   A O   1 
HETATM 5367 O  O   . HOH   I 5 .   ? 6.90223   -7.32734  34.89060 1.000 31.85144 ? 799 HOH   A O   1 
HETATM 5368 O  O   . HOH   I 5 .   ? -15.61992 1.74338   41.74520 1.000 32.02742 ? 800 HOH   A O   1 
HETATM 5369 O  O   . HOH   I 5 .   ? -24.23715 0.09508   8.52675  1.000 26.67850 ? 801 HOH   A O   1 
HETATM 5370 O  O   . HOH   I 5 .   ? -22.23952 -2.61585  30.70782 1.000 9.59263  ? 802 HOH   A O   1 
HETATM 5371 O  O   . HOH   I 5 .   ? 5.24740   -18.08806 36.98877 1.000 35.23458 ? 803 HOH   A O   1 
HETATM 5372 O  O   . HOH   I 5 .   ? -31.00966 1.97931   29.57312 1.000 28.89087 ? 804 HOH   A O   1 
HETATM 5373 O  O   . HOH   I 5 .   ? -20.79472 -5.33249  11.25183 1.000 35.79793 ? 805 HOH   A O   1 
HETATM 5374 O  O   . HOH   I 5 .   ? -22.35418 -15.67606 41.49305 1.000 21.05104 ? 806 HOH   A O   1 
HETATM 5375 O  O   . HOH   I 5 .   ? -14.42342 4.22774   40.72286 1.000 33.28080 ? 807 HOH   A O   1 
HETATM 5376 O  O   . HOH   J 5 .   ? -21.93201 -2.39730  86.97788 1.000 42.75456 ? 701 HOH   B O   1 
HETATM 5377 O  O   . HOH   J 5 .   ? -5.76203  1.54641   78.46633 1.000 44.84486 ? 702 HOH   B O   1 
HETATM 5378 O  O   . HOH   J 5 .   ? -29.43876 -3.60351  75.19981 1.000 22.18255 ? 703 HOH   B O   1 
HETATM 5379 O  O   . HOH   J 5 .   ? -25.80606 -12.75714 50.28303 1.000 12.97340 ? 704 HOH   B O   1 
HETATM 5380 O  O   . HOH   J 5 .   ? -26.24440 20.02597  56.58937 1.000 30.64518 ? 705 HOH   B O   1 
HETATM 5381 O  O   . HOH   J 5 .   ? -10.53141 9.35365   73.34116 1.000 38.59080 ? 706 HOH   B O   1 
HETATM 5382 O  O   . HOH   J 5 .   ? -3.13110  -1.36182  85.94685 1.000 20.78666 ? 707 HOH   B O   1 
HETATM 5383 O  O   . HOH   J 5 .   ? -33.52469 2.78126   47.13383 1.000 18.28326 ? 708 HOH   B O   1 
HETATM 5384 O  O   . HOH   J 5 .   ? -16.31643 -12.47682 64.62062 1.000 22.72248 ? 709 HOH   B O   1 
HETATM 5385 O  O   . HOH   J 5 .   ? -19.98400 -5.08789  60.89728 1.000 13.97821 ? 710 HOH   B O   1 
HETATM 5386 O  O   . HOH   J 5 .   ? -13.62454 -9.75852  80.79512 1.000 20.62972 ? 711 HOH   B O   1 
HETATM 5387 O  O   . HOH   J 5 .   ? 2.89482   -6.07457  86.82285 1.000 38.87050 ? 712 HOH   B O   1 
HETATM 5388 O  O   . HOH   J 5 .   ? -22.73570 -20.89787 63.15769 1.000 28.40204 ? 713 HOH   B O   1 
HETATM 5389 O  O   . HOH   J 5 .   ? -9.30392  -8.37783  46.64933 1.000 15.96707 ? 714 HOH   B O   1 
HETATM 5390 O  O   . HOH   J 5 .   ? -22.62789 -5.40012  60.46289 1.000 13.39748 ? 715 HOH   B O   1 
HETATM 5391 O  O   . HOH   J 5 .   ? -17.07992 -6.83944  59.86889 1.000 24.29446 ? 716 HOH   B O   1 
HETATM 5392 O  O   . HOH   J 5 .   ? -28.03185 -3.42566  77.59543 1.000 35.93533 ? 717 HOH   B O   1 
HETATM 5393 O  O   . HOH   J 5 .   ? -20.03023 -5.02003  68.21295 1.000 17.99883 ? 718 HOH   B O   1 
HETATM 5394 O  O   . HOH   J 5 .   ? -17.57524 1.50968   60.82727 1.000 17.59279 ? 719 HOH   B O   1 
HETATM 5395 O  O   . HOH   J 5 .   ? -14.34767 -14.11361 64.97146 1.000 23.54189 ? 720 HOH   B O   1 
HETATM 5396 O  O   . HOH   J 5 .   ? -19.85447 -0.87694  63.58738 1.000 11.77248 ? 721 HOH   B O   1 
HETATM 5397 O  O   . HOH   J 5 .   ? -24.01036 -6.38186  71.88406 1.000 17.02707 ? 722 HOH   B O   1 
HETATM 5398 O  O   . HOH   J 5 .   ? -25.28266 -15.00774 63.49888 1.000 15.80544 ? 723 HOH   B O   1 
HETATM 5399 O  O   . HOH   J 5 .   ? -13.98654 -5.53377  57.58337 1.000 18.86200 ? 724 HOH   B O   1 
HETATM 5400 O  O   . HOH   J 5 .   ? -4.82746  -8.55481  79.64661 1.000 30.70365 ? 725 HOH   B O   1 
HETATM 5401 O  O   . HOH   J 5 .   ? -12.10882 4.24952   57.60503 1.000 33.20807 ? 726 HOH   B O   1 
HETATM 5402 O  O   . HOH   J 5 .   ? -7.02842  -19.48310 69.70015 1.000 36.65732 ? 727 HOH   B O   1 
HETATM 5403 O  O   . HOH   J 5 .   ? -6.19718  -12.65372 79.17341 1.000 28.41711 ? 728 HOH   B O   1 
HETATM 5404 O  O   . HOH   J 5 .   ? -14.194   -5.302    90.973   1.000 17.33728 ? 729 HOH   B O   1 
HETATM 5405 O  O   . HOH   J 5 .   ? -29.38671 -19.15665 62.15646 1.000 27.85134 ? 730 HOH   B O   1 
HETATM 5406 O  O   . HOH   J 5 .   ? -25.45764 10.06162  78.56789 1.000 36.85436 ? 731 HOH   B O   1 
HETATM 5407 O  O   . HOH   J 5 .   ? -20.69176 -7.85452  60.19622 1.000 9.86648  ? 732 HOH   B O   1 
HETATM 5408 O  O   . HOH   J 5 .   ? -14.45382 -4.81893  54.21535 1.000 23.55773 ? 733 HOH   B O   1 
HETATM 5409 O  O   . HOH   J 5 .   ? -20.71772 -6.31286  65.85309 1.000 13.40027 ? 734 HOH   B O   1 
HETATM 5410 O  O   . HOH   J 5 .   ? -23.30157 -13.57726 78.63426 1.000 30.88511 ? 735 HOH   B O   1 
HETATM 5411 O  O   . HOH   J 5 .   ? -21.79456 -5.18359  63.35662 1.000 14.44084 ? 736 HOH   B O   1 
HETATM 5412 O  O   . HOH   J 5 .   ? -18.74272 -18.36997 69.13020 1.000 30.85234 ? 737 HOH   B O   1 
HETATM 5413 O  O   . HOH   J 5 .   ? -15.86924 -17.94300 65.97605 1.000 26.92266 ? 738 HOH   B O   1 
HETATM 5414 O  O   . HOH   J 5 .   ? -13.88478 2.91170   87.62009 1.000 25.89233 ? 739 HOH   B O   1 
HETATM 5415 O  O   . HOH   J 5 .   ? -25.74059 -4.33264  76.54114 1.000 23.33360 ? 740 HOH   B O   1 
HETATM 5416 O  O   . HOH   J 5 .   ? -11.55711 -13.83184 48.55606 1.000 18.78726 ? 741 HOH   B O   1 
HETATM 5417 O  O   . HOH   J 5 .   ? -0.10339  -20.09700 57.77521 1.000 42.54729 ? 742 HOH   B O   1 
HETATM 5418 O  O   . HOH   J 5 .   ? -18.02233 -8.73676  62.10673 1.000 15.26508 ? 743 HOH   B O   1 
HETATM 5419 O  O   . HOH   J 5 .   ? -19.55699 -3.06660  71.41862 1.000 20.78683 ? 744 HOH   B O   1 
HETATM 5420 O  O   . HOH   J 5 .   ? -18.04148 8.26851   85.75608 1.000 34.30551 ? 745 HOH   B O   1 
HETATM 5421 O  O   . HOH   J 5 .   ? -10.43899 -8.46251  74.88967 1.000 25.31052 ? 746 HOH   B O   1 
HETATM 5422 O  O   . HOH   J 5 .   ? -33.90569 24.04246  68.98336 1.000 49.10182 ? 747 HOH   B O   1 
HETATM 5423 O  O   . HOH   J 5 .   ? -17.86243 -20.74054 51.88878 1.000 27.44702 ? 748 HOH   B O   1 
HETATM 5424 O  O   . HOH   J 5 .   ? -3.51669  -1.71245  76.42954 1.000 35.98887 ? 749 HOH   B O   1 
HETATM 5425 O  O   . HOH   J 5 .   ? -15.01627 -7.36855  53.36159 1.000 15.60241 ? 750 HOH   B O   1 
HETATM 5426 O  O   . HOH   J 5 .   ? -11.83022 -8.38433  59.01853 1.000 22.70361 ? 751 HOH   B O   1 
HETATM 5427 O  O   . HOH   J 5 .   ? -28.99501 19.01062  74.42217 1.000 40.88735 ? 752 HOH   B O   1 
HETATM 5428 O  O   . HOH   J 5 .   ? -14.80079 -8.11140  59.95903 1.000 21.78463 ? 753 HOH   B O   1 
HETATM 5429 O  O   . HOH   J 5 .   ? -22.38338 -5.39595  46.85345 1.000 23.40780 ? 754 HOH   B O   1 
HETATM 5430 O  O   . HOH   J 5 .   ? -19.94969 -7.30274  62.99498 1.000 14.62925 ? 755 HOH   B O   1 
HETATM 5431 O  O   . HOH   J 5 .   ? -18.83397 -18.27590 52.80166 1.000 21.55826 ? 756 HOH   B O   1 
HETATM 5432 O  O   . HOH   J 5 .   ? -8.05468  -11.57083 48.01056 1.000 23.87745 ? 757 HOH   B O   1 
HETATM 5433 O  O   . HOH   J 5 .   ? -19.20112 -6.80622  87.10887 1.000 28.31078 ? 758 HOH   B O   1 
HETATM 5434 O  O   . HOH   J 5 .   ? -7.079    3.493     89.039   1.000 24.88093 ? 759 HOH   B O   1 
HETATM 5435 O  O   . HOH   J 5 .   ? -13.15374 -15.48952 48.11890 1.000 29.91641 ? 760 HOH   B O   1 
HETATM 5436 O  O   . HOH   J 5 .   ? -20.06969 7.18709   67.44646 1.000 38.98763 ? 761 HOH   B O   1 
HETATM 5437 O  O   . HOH   J 5 .   ? -28.53896 2.43046   47.42111 1.000 26.17548 ? 762 HOH   B O   1 
HETATM 5438 O  O   . HOH   J 5 .   ? -31.67922 -0.03668  84.06093 1.000 37.30281 ? 763 HOH   B O   1 
HETATM 5439 O  O   . HOH   J 5 .   ? -16.454   -5.227    91.209   1.000 25.35141 ? 764 HOH   B O   1 
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