data_8ZQU
# 
_entry.id   8ZQU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZQU         pdb_00008zqu 10.2210/pdb8zqu/pdb 
WWPDB D_1300048349 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZQU 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              hbluo@hainanu.edu.cn 
_pdbx_contact_author.name_first         Hai-Bin 
_pdbx_contact_author.name_last          Luo 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2163-0509 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Huang, Y.-Y.' 1 ? 
'Luo, H.-B.'   2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   CC 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Chin.Chem.Lett. 
_citation.journal_id_ASTM           CCLEE7 
_citation.journal_id_CSD            1182 
_citation.journal_id_ISSN           1001-8417 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                110586 
_citation.page_last                 ? 
_citation.title                     
'Structure-based optimization of isoaurostatin as novel PDE4 inhibitors with anti-fibrotic effects' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.cclet.2024.110586 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Huang, Y.Y.' 1  ? 
primary 'Luo, X.'     2  ? 
primary 'Zhang, K.'   3  ? 
primary 'Liang, Y.'   4  ? 
primary 'Zhang, F.'   5  ? 
primary 'Liao, G.'    6  ? 
primary 'Xie, S.'     7  ? 
primary 'Huang, P.L.' 8  ? 
primary 'Hou, S.'     9  ? 
primary 'Zhou, Q.'    10 ? 
primary 'Zou, Y.'     11 ? 
primary 'Luo, H.B.'   12 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 
;3',5'-cyclic-AMP phosphodiesterase 4D
;
57758.402 2   3.1.4.53 ? ? ? 
2 non-polymer syn 'ZINC ION'                                                                                                 
65.409    2   ?        ? ? ? 
3 non-polymer syn 'MAGNESIUM ION'                                                                                            
24.305    2   ?        ? ? ? 
4 non-polymer syn '(3~{Z})-3-[[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]methylidene]-6-oxidanyl-1-benzofuran-2-one' 
388.361   2   ?        ? ? ? 
5 water       nat water                                                                                                      
18.015    271 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'DPDE3,PDE43,cAMP-specific phosphodiesterase 4D' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIP
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL
LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLS
NPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE
QVEEEAVGEEEESQPEACVIDDRSPD
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIP
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL
LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLS
NPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE
QVEEEAVGEEEESQPEACVIDDRSPD
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                                                                                 ZN    
3 'MAGNESIUM ION'                                                                                            MG    
4 '(3~{Z})-3-[[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]methylidene]-6-oxidanyl-1-benzofuran-2-one' A1D8P 
5 water                                                                                                      HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   SER n 
1 4   ASN n 
1 5   LYS n 
1 6   PHE n 
1 7   LYS n 
1 8   ARG n 
1 9   MET n 
1 10  LEU n 
1 11  ASN n 
1 12  ARG n 
1 13  GLU n 
1 14  LEU n 
1 15  THR n 
1 16  HIS n 
1 17  LEU n 
1 18  SER n 
1 19  GLU n 
1 20  MET n 
1 21  SER n 
1 22  ARG n 
1 23  SER n 
1 24  GLY n 
1 25  ASN n 
1 26  GLN n 
1 27  VAL n 
1 28  SER n 
1 29  GLU n 
1 30  PHE n 
1 31  ILE n 
1 32  SER n 
1 33  ASN n 
1 34  THR n 
1 35  PHE n 
1 36  LEU n 
1 37  ASP n 
1 38  LYS n 
1 39  GLN n 
1 40  HIS n 
1 41  GLU n 
1 42  VAL n 
1 43  GLU n 
1 44  ILE n 
1 45  PRO n 
1 46  SER n 
1 47  PRO n 
1 48  THR n 
1 49  GLN n 
1 50  LYS n 
1 51  GLU n 
1 52  LYS n 
1 53  GLU n 
1 54  LYS n 
1 55  LYS n 
1 56  LYS n 
1 57  ARG n 
1 58  PRO n 
1 59  MET n 
1 60  SER n 
1 61  GLN n 
1 62  ILE n 
1 63  SER n 
1 64  GLY n 
1 65  VAL n 
1 66  LYS n 
1 67  LYS n 
1 68  LEU n 
1 69  MET n 
1 70  HIS n 
1 71  SER n 
1 72  SER n 
1 73  SER n 
1 74  LEU n 
1 75  THR n 
1 76  ASN n 
1 77  SER n 
1 78  SER n 
1 79  ILE n 
1 80  PRO n 
1 81  ARG n 
1 82  PHE n 
1 83  GLY n 
1 84  VAL n 
1 85  LYS n 
1 86  THR n 
1 87  GLU n 
1 88  GLN n 
1 89  GLU n 
1 90  ASP n 
1 91  VAL n 
1 92  LEU n 
1 93  ALA n 
1 94  LYS n 
1 95  GLU n 
1 96  LEU n 
1 97  GLU n 
1 98  ASP n 
1 99  VAL n 
1 100 ASN n 
1 101 LYS n 
1 102 TRP n 
1 103 GLY n 
1 104 LEU n 
1 105 HIS n 
1 106 VAL n 
1 107 PHE n 
1 108 ARG n 
1 109 ILE n 
1 110 ALA n 
1 111 GLU n 
1 112 LEU n 
1 113 SER n 
1 114 GLY n 
1 115 ASN n 
1 116 ARG n 
1 117 PRO n 
1 118 LEU n 
1 119 THR n 
1 120 VAL n 
1 121 ILE n 
1 122 MET n 
1 123 HIS n 
1 124 THR n 
1 125 ILE n 
1 126 PHE n 
1 127 GLN n 
1 128 GLU n 
1 129 ARG n 
1 130 ASP n 
1 131 LEU n 
1 132 LEU n 
1 133 LYS n 
1 134 THR n 
1 135 PHE n 
1 136 LYS n 
1 137 ILE n 
1 138 PRO n 
1 139 VAL n 
1 140 ASP n 
1 141 THR n 
1 142 LEU n 
1 143 ILE n 
1 144 THR n 
1 145 TYR n 
1 146 LEU n 
1 147 MET n 
1 148 THR n 
1 149 LEU n 
1 150 GLU n 
1 151 ASP n 
1 152 HIS n 
1 153 TYR n 
1 154 HIS n 
1 155 ALA n 
1 156 ASP n 
1 157 VAL n 
1 158 ALA n 
1 159 TYR n 
1 160 HIS n 
1 161 ASN n 
1 162 ASN n 
1 163 ILE n 
1 164 HIS n 
1 165 ALA n 
1 166 ALA n 
1 167 ASP n 
1 168 VAL n 
1 169 VAL n 
1 170 GLN n 
1 171 SER n 
1 172 THR n 
1 173 HIS n 
1 174 VAL n 
1 175 LEU n 
1 176 LEU n 
1 177 SER n 
1 178 THR n 
1 179 PRO n 
1 180 ALA n 
1 181 LEU n 
1 182 GLU n 
1 183 ALA n 
1 184 VAL n 
1 185 PHE n 
1 186 THR n 
1 187 ASP n 
1 188 LEU n 
1 189 GLU n 
1 190 ILE n 
1 191 LEU n 
1 192 ALA n 
1 193 ALA n 
1 194 ILE n 
1 195 PHE n 
1 196 ALA n 
1 197 SER n 
1 198 ALA n 
1 199 ILE n 
1 200 HIS n 
1 201 ASP n 
1 202 VAL n 
1 203 ASP n 
1 204 HIS n 
1 205 PRO n 
1 206 GLY n 
1 207 VAL n 
1 208 SER n 
1 209 ASN n 
1 210 GLN n 
1 211 PHE n 
1 212 LEU n 
1 213 ILE n 
1 214 ASN n 
1 215 THR n 
1 216 ASN n 
1 217 SER n 
1 218 GLU n 
1 219 LEU n 
1 220 ALA n 
1 221 LEU n 
1 222 MET n 
1 223 TYR n 
1 224 ASN n 
1 225 ASP n 
1 226 SER n 
1 227 SER n 
1 228 VAL n 
1 229 LEU n 
1 230 GLU n 
1 231 ASN n 
1 232 HIS n 
1 233 HIS n 
1 234 LEU n 
1 235 ALA n 
1 236 VAL n 
1 237 GLY n 
1 238 PHE n 
1 239 LYS n 
1 240 LEU n 
1 241 LEU n 
1 242 GLN n 
1 243 GLU n 
1 244 GLU n 
1 245 ASN n 
1 246 CYS n 
1 247 ASP n 
1 248 ILE n 
1 249 PHE n 
1 250 GLN n 
1 251 ASN n 
1 252 LEU n 
1 253 THR n 
1 254 LYS n 
1 255 LYS n 
1 256 GLN n 
1 257 ARG n 
1 258 GLN n 
1 259 SER n 
1 260 LEU n 
1 261 ARG n 
1 262 LYS n 
1 263 MET n 
1 264 VAL n 
1 265 ILE n 
1 266 ASP n 
1 267 ILE n 
1 268 VAL n 
1 269 LEU n 
1 270 ALA n 
1 271 THR n 
1 272 ASP n 
1 273 MET n 
1 274 SER n 
1 275 LYS n 
1 276 HIS n 
1 277 MET n 
1 278 ASN n 
1 279 LEU n 
1 280 LEU n 
1 281 ALA n 
1 282 ASP n 
1 283 LEU n 
1 284 LYS n 
1 285 THR n 
1 286 MET n 
1 287 VAL n 
1 288 GLU n 
1 289 THR n 
1 290 LYS n 
1 291 LYS n 
1 292 VAL n 
1 293 THR n 
1 294 SER n 
1 295 SER n 
1 296 GLY n 
1 297 VAL n 
1 298 LEU n 
1 299 LEU n 
1 300 LEU n 
1 301 ASP n 
1 302 ASN n 
1 303 TYR n 
1 304 SER n 
1 305 ASP n 
1 306 ARG n 
1 307 ILE n 
1 308 GLN n 
1 309 VAL n 
1 310 LEU n 
1 311 GLN n 
1 312 ASN n 
1 313 MET n 
1 314 VAL n 
1 315 HIS n 
1 316 CYS n 
1 317 ALA n 
1 318 ASP n 
1 319 LEU n 
1 320 SER n 
1 321 ASN n 
1 322 PRO n 
1 323 THR n 
1 324 LYS n 
1 325 PRO n 
1 326 LEU n 
1 327 GLN n 
1 328 LEU n 
1 329 TYR n 
1 330 ARG n 
1 331 GLN n 
1 332 TRP n 
1 333 THR n 
1 334 ASP n 
1 335 ARG n 
1 336 ILE n 
1 337 MET n 
1 338 GLU n 
1 339 GLU n 
1 340 PHE n 
1 341 PHE n 
1 342 ARG n 
1 343 GLN n 
1 344 GLY n 
1 345 ASP n 
1 346 ARG n 
1 347 GLU n 
1 348 ARG n 
1 349 GLU n 
1 350 ARG n 
1 351 GLY n 
1 352 MET n 
1 353 GLU n 
1 354 ILE n 
1 355 SER n 
1 356 PRO n 
1 357 MET n 
1 358 CYS n 
1 359 ASP n 
1 360 LYS n 
1 361 HIS n 
1 362 ASN n 
1 363 ALA n 
1 364 SER n 
1 365 VAL n 
1 366 GLU n 
1 367 LYS n 
1 368 SER n 
1 369 GLN n 
1 370 VAL n 
1 371 GLY n 
1 372 PHE n 
1 373 ILE n 
1 374 ASP n 
1 375 TYR n 
1 376 ILE n 
1 377 VAL n 
1 378 HIS n 
1 379 PRO n 
1 380 LEU n 
1 381 TRP n 
1 382 GLU n 
1 383 THR n 
1 384 TRP n 
1 385 ALA n 
1 386 ASP n 
1 387 LEU n 
1 388 VAL n 
1 389 HIS n 
1 390 PRO n 
1 391 ASP n 
1 392 ALA n 
1 393 GLN n 
1 394 ASP n 
1 395 ILE n 
1 396 LEU n 
1 397 ASP n 
1 398 THR n 
1 399 LEU n 
1 400 GLU n 
1 401 ASP n 
1 402 ASN n 
1 403 ARG n 
1 404 GLU n 
1 405 TRP n 
1 406 TYR n 
1 407 GLN n 
1 408 SER n 
1 409 THR n 
1 410 ILE n 
1 411 PRO n 
1 412 GLN n 
1 413 SER n 
1 414 PRO n 
1 415 SER n 
1 416 PRO n 
1 417 ALA n 
1 418 PRO n 
1 419 ASP n 
1 420 ASP n 
1 421 PRO n 
1 422 GLU n 
1 423 GLU n 
1 424 GLY n 
1 425 ARG n 
1 426 GLN n 
1 427 GLY n 
1 428 GLN n 
1 429 THR n 
1 430 GLU n 
1 431 LYS n 
1 432 PHE n 
1 433 GLN n 
1 434 PHE n 
1 435 GLU n 
1 436 LEU n 
1 437 THR n 
1 438 LEU n 
1 439 GLU n 
1 440 GLU n 
1 441 ASP n 
1 442 GLY n 
1 443 GLU n 
1 444 SER n 
1 445 ASP n 
1 446 THR n 
1 447 GLU n 
1 448 LYS n 
1 449 ASP n 
1 450 SER n 
1 451 GLY n 
1 452 SER n 
1 453 GLN n 
1 454 VAL n 
1 455 GLU n 
1 456 GLU n 
1 457 ASP n 
1 458 THR n 
1 459 SER n 
1 460 CYS n 
1 461 SER n 
1 462 ASP n 
1 463 SER n 
1 464 LYS n 
1 465 THR n 
1 466 LEU n 
1 467 CYS n 
1 468 THR n 
1 469 GLN n 
1 470 ASP n 
1 471 SER n 
1 472 GLU n 
1 473 SER n 
1 474 THR n 
1 475 GLU n 
1 476 ILE n 
1 477 PRO n 
1 478 LEU n 
1 479 ASP n 
1 480 GLU n 
1 481 GLN n 
1 482 VAL n 
1 483 GLU n 
1 484 GLU n 
1 485 GLU n 
1 486 ALA n 
1 487 VAL n 
1 488 GLY n 
1 489 GLU n 
1 490 GLU n 
1 491 GLU n 
1 492 GLU n 
1 493 SER n 
1 494 GLN n 
1 495 PRO n 
1 496 GLU n 
1 497 ALA n 
1 498 CYS n 
1 499 VAL n 
1 500 ILE n 
1 501 ASP n 
1 502 ASP n 
1 503 ARG n 
1 504 SER n 
1 505 PRO n 
1 506 ASP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   506 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'PDE4D, DPDE3' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     511693 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1D8P non-polymer         . 
'(3~{Z})-3-[[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]methylidene]-6-oxidanyl-1-benzofuran-2-one' ? 'C21 H18 F2 O5'  
388.361 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
MG    non-polymer         . 'MAGNESIUM ION' ? 'Mg 2'           24.305  
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
ZN    non-polymer         . 'ZINC ION' ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   SER 3   3   ?   ?   ?   A . n 
A 1 4   ASN 4   4   ?   ?   ?   A . n 
A 1 5   LYS 5   5   ?   ?   ?   A . n 
A 1 6   PHE 6   6   ?   ?   ?   A . n 
A 1 7   LYS 7   7   ?   ?   ?   A . n 
A 1 8   ARG 8   8   ?   ?   ?   A . n 
A 1 9   MET 9   9   ?   ?   ?   A . n 
A 1 10  LEU 10  10  ?   ?   ?   A . n 
A 1 11  ASN 11  11  ?   ?   ?   A . n 
A 1 12  ARG 12  12  ?   ?   ?   A . n 
A 1 13  GLU 13  13  ?   ?   ?   A . n 
A 1 14  LEU 14  14  ?   ?   ?   A . n 
A 1 15  THR 15  15  ?   ?   ?   A . n 
A 1 16  HIS 16  16  ?   ?   ?   A . n 
A 1 17  LEU 17  17  ?   ?   ?   A . n 
A 1 18  SER 18  18  ?   ?   ?   A . n 
A 1 19  GLU 19  19  ?   ?   ?   A . n 
A 1 20  MET 20  20  ?   ?   ?   A . n 
A 1 21  SER 21  21  ?   ?   ?   A . n 
A 1 22  ARG 22  22  ?   ?   ?   A . n 
A 1 23  SER 23  23  ?   ?   ?   A . n 
A 1 24  GLY 24  24  ?   ?   ?   A . n 
A 1 25  ASN 25  25  ?   ?   ?   A . n 
A 1 26  GLN 26  26  ?   ?   ?   A . n 
A 1 27  VAL 27  27  ?   ?   ?   A . n 
A 1 28  SER 28  28  ?   ?   ?   A . n 
A 1 29  GLU 29  29  ?   ?   ?   A . n 
A 1 30  PHE 30  30  ?   ?   ?   A . n 
A 1 31  ILE 31  31  ?   ?   ?   A . n 
A 1 32  SER 32  32  ?   ?   ?   A . n 
A 1 33  ASN 33  33  ?   ?   ?   A . n 
A 1 34  THR 34  34  ?   ?   ?   A . n 
A 1 35  PHE 35  35  ?   ?   ?   A . n 
A 1 36  LEU 36  36  ?   ?   ?   A . n 
A 1 37  ASP 37  37  ?   ?   ?   A . n 
A 1 38  LYS 38  38  ?   ?   ?   A . n 
A 1 39  GLN 39  39  ?   ?   ?   A . n 
A 1 40  HIS 40  40  ?   ?   ?   A . n 
A 1 41  GLU 41  41  ?   ?   ?   A . n 
A 1 42  VAL 42  42  ?   ?   ?   A . n 
A 1 43  GLU 43  43  ?   ?   ?   A . n 
A 1 44  ILE 44  44  ?   ?   ?   A . n 
A 1 45  PRO 45  45  ?   ?   ?   A . n 
A 1 46  SER 46  46  ?   ?   ?   A . n 
A 1 47  PRO 47  47  ?   ?   ?   A . n 
A 1 48  THR 48  48  ?   ?   ?   A . n 
A 1 49  GLN 49  49  ?   ?   ?   A . n 
A 1 50  LYS 50  50  ?   ?   ?   A . n 
A 1 51  GLU 51  51  ?   ?   ?   A . n 
A 1 52  LYS 52  52  ?   ?   ?   A . n 
A 1 53  GLU 53  53  ?   ?   ?   A . n 
A 1 54  LYS 54  54  ?   ?   ?   A . n 
A 1 55  LYS 55  55  ?   ?   ?   A . n 
A 1 56  LYS 56  56  ?   ?   ?   A . n 
A 1 57  ARG 57  57  ?   ?   ?   A . n 
A 1 58  PRO 58  58  ?   ?   ?   A . n 
A 1 59  MET 59  59  ?   ?   ?   A . n 
A 1 60  SER 60  60  ?   ?   ?   A . n 
A 1 61  GLN 61  61  ?   ?   ?   A . n 
A 1 62  ILE 62  62  ?   ?   ?   A . n 
A 1 63  SER 63  63  ?   ?   ?   A . n 
A 1 64  GLY 64  64  ?   ?   ?   A . n 
A 1 65  VAL 65  65  ?   ?   ?   A . n 
A 1 66  LYS 66  66  ?   ?   ?   A . n 
A 1 67  LYS 67  67  ?   ?   ?   A . n 
A 1 68  LEU 68  68  ?   ?   ?   A . n 
A 1 69  MET 69  69  ?   ?   ?   A . n 
A 1 70  HIS 70  70  ?   ?   ?   A . n 
A 1 71  SER 71  71  ?   ?   ?   A . n 
A 1 72  SER 72  72  ?   ?   ?   A . n 
A 1 73  SER 73  73  ?   ?   ?   A . n 
A 1 74  LEU 74  74  ?   ?   ?   A . n 
A 1 75  THR 75  75  ?   ?   ?   A . n 
A 1 76  ASN 76  76  ?   ?   ?   A . n 
A 1 77  SER 77  77  ?   ?   ?   A . n 
A 1 78  SER 78  78  ?   ?   ?   A . n 
A 1 79  ILE 79  79  ?   ?   ?   A . n 
A 1 80  PRO 80  80  ?   ?   ?   A . n 
A 1 81  ARG 81  81  ?   ?   ?   A . n 
A 1 82  PHE 82  82  ?   ?   ?   A . n 
A 1 83  GLY 83  83  ?   ?   ?   A . n 
A 1 84  VAL 84  84  ?   ?   ?   A . n 
A 1 85  LYS 85  85  ?   ?   ?   A . n 
A 1 86  THR 86  86  ?   ?   ?   A . n 
A 1 87  GLU 87  87  87  GLU GLU A . n 
A 1 88  GLN 88  88  88  GLN GLN A . n 
A 1 89  GLU 89  89  89  GLU GLU A . n 
A 1 90  ASP 90  90  90  ASP ASP A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  ALA 93  93  93  ALA ALA A . n 
A 1 94  LYS 94  94  94  LYS LYS A . n 
A 1 95  GLU 95  95  95  GLU GLU A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  GLU 97  97  97  GLU GLU A . n 
A 1 98  ASP 98  98  98  ASP ASP A . n 
A 1 99  VAL 99  99  99  VAL VAL A . n 
A 1 100 ASN 100 100 100 ASN ASN A . n 
A 1 101 LYS 101 101 101 LYS LYS A . n 
A 1 102 TRP 102 102 102 TRP TRP A . n 
A 1 103 GLY 103 103 103 GLY GLY A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 HIS 105 105 105 HIS HIS A . n 
A 1 106 VAL 106 106 106 VAL VAL A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 ARG 108 108 108 ARG ARG A . n 
A 1 109 ILE 109 109 109 ILE ILE A . n 
A 1 110 ALA 110 110 110 ALA ALA A . n 
A 1 111 GLU 111 111 111 GLU GLU A . n 
A 1 112 LEU 112 112 112 LEU LEU A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 GLY 114 114 114 GLY GLY A . n 
A 1 115 ASN 115 115 115 ASN ASN A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 PRO 117 117 117 PRO PRO A . n 
A 1 118 LEU 118 118 118 LEU LEU A . n 
A 1 119 THR 119 119 119 THR THR A . n 
A 1 120 VAL 120 120 120 VAL VAL A . n 
A 1 121 ILE 121 121 121 ILE ILE A . n 
A 1 122 MET 122 122 122 MET MET A . n 
A 1 123 HIS 123 123 123 HIS HIS A . n 
A 1 124 THR 124 124 124 THR THR A . n 
A 1 125 ILE 125 125 125 ILE ILE A . n 
A 1 126 PHE 126 126 126 PHE PHE A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 GLU 128 128 128 GLU GLU A . n 
A 1 129 ARG 129 129 129 ARG ARG A . n 
A 1 130 ASP 130 130 130 ASP ASP A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 LYS 133 133 133 LYS LYS A . n 
A 1 134 THR 134 134 134 THR THR A . n 
A 1 135 PHE 135 135 135 PHE PHE A . n 
A 1 136 LYS 136 136 136 LYS LYS A . n 
A 1 137 ILE 137 137 137 ILE ILE A . n 
A 1 138 PRO 138 138 138 PRO PRO A . n 
A 1 139 VAL 139 139 139 VAL VAL A . n 
A 1 140 ASP 140 140 140 ASP ASP A . n 
A 1 141 THR 141 141 141 THR THR A . n 
A 1 142 LEU 142 142 142 LEU LEU A . n 
A 1 143 ILE 143 143 143 ILE ILE A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 TYR 145 145 145 TYR TYR A . n 
A 1 146 LEU 146 146 146 LEU LEU A . n 
A 1 147 MET 147 147 147 MET MET A . n 
A 1 148 THR 148 148 148 THR THR A . n 
A 1 149 LEU 149 149 149 LEU LEU A . n 
A 1 150 GLU 150 150 150 GLU GLU A . n 
A 1 151 ASP 151 151 151 ASP ASP A . n 
A 1 152 HIS 152 152 152 HIS HIS A . n 
A 1 153 TYR 153 153 153 TYR TYR A . n 
A 1 154 HIS 154 154 154 HIS HIS A . n 
A 1 155 ALA 155 155 155 ALA ALA A . n 
A 1 156 ASP 156 156 156 ASP ASP A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 ALA 158 158 158 ALA ALA A . n 
A 1 159 TYR 159 159 159 TYR TYR A . n 
A 1 160 HIS 160 160 160 HIS HIS A . n 
A 1 161 ASN 161 161 161 ASN ASN A . n 
A 1 162 ASN 162 162 162 ASN ASN A . n 
A 1 163 ILE 163 163 163 ILE ILE A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 ALA 165 165 165 ALA ALA A . n 
A 1 166 ALA 166 166 166 ALA ALA A . n 
A 1 167 ASP 167 167 167 ASP ASP A . n 
A 1 168 VAL 168 168 168 VAL VAL A . n 
A 1 169 VAL 169 169 169 VAL VAL A . n 
A 1 170 GLN 170 170 170 GLN GLN A . n 
A 1 171 SER 171 171 171 SER SER A . n 
A 1 172 THR 172 172 172 THR THR A . n 
A 1 173 HIS 173 173 173 HIS HIS A . n 
A 1 174 VAL 174 174 174 VAL VAL A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 LEU 176 176 176 LEU LEU A . n 
A 1 177 SER 177 177 177 SER SER A . n 
A 1 178 THR 178 178 178 THR THR A . n 
A 1 179 PRO 179 179 179 PRO PRO A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 LEU 181 181 181 LEU LEU A . n 
A 1 182 GLU 182 182 182 GLU GLU A . n 
A 1 183 ALA 183 183 183 ALA ALA A . n 
A 1 184 VAL 184 184 184 VAL VAL A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 THR 186 186 186 THR THR A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 GLU 189 189 189 GLU GLU A . n 
A 1 190 ILE 190 190 190 ILE ILE A . n 
A 1 191 LEU 191 191 191 LEU LEU A . n 
A 1 192 ALA 192 192 192 ALA ALA A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 PHE 195 195 195 PHE PHE A . n 
A 1 196 ALA 196 196 196 ALA ALA A . n 
A 1 197 SER 197 197 197 SER SER A . n 
A 1 198 ALA 198 198 198 ALA ALA A . n 
A 1 199 ILE 199 199 199 ILE ILE A . n 
A 1 200 HIS 200 200 200 HIS HIS A . n 
A 1 201 ASP 201 201 201 ASP ASP A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASP 203 203 203 ASP ASP A . n 
A 1 204 HIS 204 204 204 HIS HIS A . n 
A 1 205 PRO 205 205 205 PRO PRO A . n 
A 1 206 GLY 206 206 206 GLY GLY A . n 
A 1 207 VAL 207 207 207 VAL VAL A . n 
A 1 208 SER 208 208 208 SER SER A . n 
A 1 209 ASN 209 209 209 ASN ASN A . n 
A 1 210 GLN 210 210 210 GLN GLN A . n 
A 1 211 PHE 211 211 211 PHE PHE A . n 
A 1 212 LEU 212 212 212 LEU LEU A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 THR 215 215 215 THR THR A . n 
A 1 216 ASN 216 216 216 ASN ASN A . n 
A 1 217 SER 217 217 217 SER SER A . n 
A 1 218 GLU 218 218 218 GLU GLU A . n 
A 1 219 LEU 219 219 219 LEU LEU A . n 
A 1 220 ALA 220 220 220 ALA ALA A . n 
A 1 221 LEU 221 221 221 LEU LEU A . n 
A 1 222 MET 222 222 222 MET MET A . n 
A 1 223 TYR 223 223 223 TYR TYR A . n 
A 1 224 ASN 224 224 224 ASN ASN A . n 
A 1 225 ASP 225 225 225 ASP ASP A . n 
A 1 226 SER 226 226 226 SER SER A . n 
A 1 227 SER 227 227 227 SER SER A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 LEU 229 229 229 LEU LEU A . n 
A 1 230 GLU 230 230 230 GLU GLU A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 HIS 232 232 232 HIS HIS A . n 
A 1 233 HIS 233 233 233 HIS HIS A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 ALA 235 235 235 ALA ALA A . n 
A 1 236 VAL 236 236 236 VAL VAL A . n 
A 1 237 GLY 237 237 237 GLY GLY A . n 
A 1 238 PHE 238 238 238 PHE PHE A . n 
A 1 239 LYS 239 239 239 LYS LYS A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 LEU 241 241 241 LEU LEU A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 GLU 243 243 243 GLU GLU A . n 
A 1 244 GLU 244 244 244 GLU GLU A . n 
A 1 245 ASN 245 245 245 ASN ASN A . n 
A 1 246 CYS 246 246 246 CYS CYS A . n 
A 1 247 ASP 247 247 247 ASP ASP A . n 
A 1 248 ILE 248 248 248 ILE ILE A . n 
A 1 249 PHE 249 249 249 PHE PHE A . n 
A 1 250 GLN 250 250 250 GLN GLN A . n 
A 1 251 ASN 251 251 251 ASN ASN A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 THR 253 253 253 THR THR A . n 
A 1 254 LYS 254 254 254 LYS LYS A . n 
A 1 255 LYS 255 255 255 LYS LYS A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 ARG 257 257 257 ARG ARG A . n 
A 1 258 GLN 258 258 258 GLN GLN A . n 
A 1 259 SER 259 259 259 SER SER A . n 
A 1 260 LEU 260 260 260 LEU LEU A . n 
A 1 261 ARG 261 261 261 ARG ARG A . n 
A 1 262 LYS 262 262 262 LYS LYS A . n 
A 1 263 MET 263 263 263 MET MET A . n 
A 1 264 VAL 264 264 264 VAL VAL A . n 
A 1 265 ILE 265 265 265 ILE ILE A . n 
A 1 266 ASP 266 266 266 ASP ASP A . n 
A 1 267 ILE 267 267 267 ILE ILE A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 LEU 269 269 269 LEU LEU A . n 
A 1 270 ALA 270 270 270 ALA ALA A . n 
A 1 271 THR 271 271 271 THR THR A . n 
A 1 272 ASP 272 272 272 ASP ASP A . n 
A 1 273 MET 273 273 273 MET MET A . n 
A 1 274 SER 274 274 274 SER SER A . n 
A 1 275 LYS 275 275 275 LYS LYS A . n 
A 1 276 HIS 276 276 276 HIS HIS A . n 
A 1 277 MET 277 277 277 MET MET A . n 
A 1 278 ASN 278 278 278 ASN ASN A . n 
A 1 279 LEU 279 279 279 LEU LEU A . n 
A 1 280 LEU 280 280 280 LEU LEU A . n 
A 1 281 ALA 281 281 281 ALA ALA A . n 
A 1 282 ASP 282 282 282 ASP ASP A . n 
A 1 283 LEU 283 283 283 LEU LEU A . n 
A 1 284 LYS 284 284 284 LYS LYS A . n 
A 1 285 THR 285 285 285 THR THR A . n 
A 1 286 MET 286 286 286 MET MET A . n 
A 1 287 VAL 287 287 287 VAL VAL A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 THR 289 289 289 THR THR A . n 
A 1 290 LYS 290 290 290 LYS LYS A . n 
A 1 291 LYS 291 291 291 LYS LYS A . n 
A 1 292 VAL 292 292 292 VAL VAL A . n 
A 1 293 THR 293 293 293 THR THR A . n 
A 1 294 SER 294 294 294 SER SER A . n 
A 1 295 SER 295 295 295 SER SER A . n 
A 1 296 GLY 296 296 296 GLY GLY A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 LEU 300 300 300 LEU LEU A . n 
A 1 301 ASP 301 301 301 ASP ASP A . n 
A 1 302 ASN 302 302 302 ASN ASN A . n 
A 1 303 TYR 303 303 303 TYR TYR A . n 
A 1 304 SER 304 304 304 SER SER A . n 
A 1 305 ASP 305 305 305 ASP ASP A . n 
A 1 306 ARG 306 306 306 ARG ARG A . n 
A 1 307 ILE 307 307 307 ILE ILE A . n 
A 1 308 GLN 308 308 308 GLN GLN A . n 
A 1 309 VAL 309 309 309 VAL VAL A . n 
A 1 310 LEU 310 310 310 LEU LEU A . n 
A 1 311 GLN 311 311 311 GLN GLN A . n 
A 1 312 ASN 312 312 312 ASN ASN A . n 
A 1 313 MET 313 313 313 MET MET A . n 
A 1 314 VAL 314 314 314 VAL VAL A . n 
A 1 315 HIS 315 315 315 HIS HIS A . n 
A 1 316 CYS 316 316 316 CYS CYS A . n 
A 1 317 ALA 317 317 317 ALA ALA A . n 
A 1 318 ASP 318 318 318 ASP ASP A . n 
A 1 319 LEU 319 319 319 LEU LEU A . n 
A 1 320 SER 320 320 320 SER SER A . n 
A 1 321 ASN 321 321 321 ASN ASN A . n 
A 1 322 PRO 322 322 322 PRO PRO A . n 
A 1 323 THR 323 323 323 THR THR A . n 
A 1 324 LYS 324 324 324 LYS LYS A . n 
A 1 325 PRO 325 325 325 PRO PRO A . n 
A 1 326 LEU 326 326 326 LEU LEU A . n 
A 1 327 GLN 327 327 327 GLN GLN A . n 
A 1 328 LEU 328 328 328 LEU LEU A . n 
A 1 329 TYR 329 329 329 TYR TYR A . n 
A 1 330 ARG 330 330 330 ARG ARG A . n 
A 1 331 GLN 331 331 331 GLN GLN A . n 
A 1 332 TRP 332 332 332 TRP TRP A . n 
A 1 333 THR 333 333 333 THR THR A . n 
A 1 334 ASP 334 334 334 ASP ASP A . n 
A 1 335 ARG 335 335 335 ARG ARG A . n 
A 1 336 ILE 336 336 336 ILE ILE A . n 
A 1 337 MET 337 337 337 MET MET A . n 
A 1 338 GLU 338 338 338 GLU GLU A . n 
A 1 339 GLU 339 339 339 GLU GLU A . n 
A 1 340 PHE 340 340 340 PHE PHE A . n 
A 1 341 PHE 341 341 341 PHE PHE A . n 
A 1 342 ARG 342 342 342 ARG ARG A . n 
A 1 343 GLN 343 343 343 GLN GLN A . n 
A 1 344 GLY 344 344 344 GLY GLY A . n 
A 1 345 ASP 345 345 345 ASP ASP A . n 
A 1 346 ARG 346 346 346 ARG ARG A . n 
A 1 347 GLU 347 347 347 GLU GLU A . n 
A 1 348 ARG 348 348 348 ARG ARG A . n 
A 1 349 GLU 349 349 349 GLU GLU A . n 
A 1 350 ARG 350 350 350 ARG ARG A . n 
A 1 351 GLY 351 351 351 GLY GLY A . n 
A 1 352 MET 352 352 352 MET MET A . n 
A 1 353 GLU 353 353 353 GLU GLU A . n 
A 1 354 ILE 354 354 354 ILE ILE A . n 
A 1 355 SER 355 355 355 SER SER A . n 
A 1 356 PRO 356 356 356 PRO PRO A . n 
A 1 357 MET 357 357 357 MET MET A . n 
A 1 358 CYS 358 358 358 CYS CYS A . n 
A 1 359 ASP 359 359 359 ASP ASP A . n 
A 1 360 LYS 360 360 360 LYS LYS A . n 
A 1 361 HIS 361 361 361 HIS HIS A . n 
A 1 362 ASN 362 362 362 ASN ASN A . n 
A 1 363 ALA 363 363 363 ALA ALA A . n 
A 1 364 SER 364 364 364 SER SER A . n 
A 1 365 VAL 365 365 365 VAL VAL A . n 
A 1 366 GLU 366 366 366 GLU GLU A . n 
A 1 367 LYS 367 367 367 LYS LYS A . n 
A 1 368 SER 368 368 368 SER SER A . n 
A 1 369 GLN 369 369 369 GLN GLN A . n 
A 1 370 VAL 370 370 370 VAL VAL A . n 
A 1 371 GLY 371 371 371 GLY GLY A . n 
A 1 372 PHE 372 372 372 PHE PHE A . n 
A 1 373 ILE 373 373 373 ILE ILE A . n 
A 1 374 ASP 374 374 374 ASP ASP A . n 
A 1 375 TYR 375 375 375 TYR TYR A . n 
A 1 376 ILE 376 376 376 ILE ILE A . n 
A 1 377 VAL 377 377 377 VAL VAL A . n 
A 1 378 HIS 378 378 378 HIS HIS A . n 
A 1 379 PRO 379 379 379 PRO PRO A . n 
A 1 380 LEU 380 380 380 LEU LEU A . n 
A 1 381 TRP 381 381 381 TRP TRP A . n 
A 1 382 GLU 382 382 382 GLU GLU A . n 
A 1 383 THR 383 383 383 THR THR A . n 
A 1 384 TRP 384 384 384 TRP TRP A . n 
A 1 385 ALA 385 385 385 ALA ALA A . n 
A 1 386 ASP 386 386 386 ASP ASP A . n 
A 1 387 LEU 387 387 387 LEU LEU A . n 
A 1 388 VAL 388 388 388 VAL VAL A . n 
A 1 389 HIS 389 389 389 HIS HIS A . n 
A 1 390 PRO 390 390 390 PRO PRO A . n 
A 1 391 ASP 391 391 391 ASP ASP A . n 
A 1 392 ALA 392 392 392 ALA ALA A . n 
A 1 393 GLN 393 393 393 GLN GLN A . n 
A 1 394 ASP 394 394 394 ASP ASP A . n 
A 1 395 ILE 395 395 395 ILE ILE A . n 
A 1 396 LEU 396 396 396 LEU LEU A . n 
A 1 397 ASP 397 397 397 ASP ASP A . n 
A 1 398 THR 398 398 398 THR THR A . n 
A 1 399 LEU 399 399 399 LEU LEU A . n 
A 1 400 GLU 400 400 400 GLU GLU A . n 
A 1 401 ASP 401 401 401 ASP ASP A . n 
A 1 402 ASN 402 402 402 ASN ASN A . n 
A 1 403 ARG 403 403 403 ARG ARG A . n 
A 1 404 GLU 404 404 404 GLU GLU A . n 
A 1 405 TRP 405 405 405 TRP TRP A . n 
A 1 406 TYR 406 406 406 TYR TYR A . n 
A 1 407 GLN 407 407 407 GLN GLN A . n 
A 1 408 SER 408 408 408 SER SER A . n 
A 1 409 THR 409 409 409 THR THR A . n 
A 1 410 ILE 410 410 410 ILE ILE A . n 
A 1 411 PRO 411 411 ?   ?   ?   A . n 
A 1 412 GLN 412 412 ?   ?   ?   A . n 
A 1 413 SER 413 413 ?   ?   ?   A . n 
A 1 414 PRO 414 414 ?   ?   ?   A . n 
A 1 415 SER 415 415 ?   ?   ?   A . n 
A 1 416 PRO 416 416 ?   ?   ?   A . n 
A 1 417 ALA 417 417 ?   ?   ?   A . n 
A 1 418 PRO 418 418 ?   ?   ?   A . n 
A 1 419 ASP 419 419 ?   ?   ?   A . n 
A 1 420 ASP 420 420 ?   ?   ?   A . n 
A 1 421 PRO 421 421 ?   ?   ?   A . n 
A 1 422 GLU 422 422 ?   ?   ?   A . n 
A 1 423 GLU 423 423 ?   ?   ?   A . n 
A 1 424 GLY 424 424 ?   ?   ?   A . n 
A 1 425 ARG 425 425 ?   ?   ?   A . n 
A 1 426 GLN 426 426 ?   ?   ?   A . n 
A 1 427 GLY 427 427 ?   ?   ?   A . n 
A 1 428 GLN 428 428 ?   ?   ?   A . n 
A 1 429 THR 429 429 ?   ?   ?   A . n 
A 1 430 GLU 430 430 ?   ?   ?   A . n 
A 1 431 LYS 431 431 ?   ?   ?   A . n 
A 1 432 PHE 432 432 ?   ?   ?   A . n 
A 1 433 GLN 433 433 ?   ?   ?   A . n 
A 1 434 PHE 434 434 ?   ?   ?   A . n 
A 1 435 GLU 435 435 ?   ?   ?   A . n 
A 1 436 LEU 436 436 ?   ?   ?   A . n 
A 1 437 THR 437 437 ?   ?   ?   A . n 
A 1 438 LEU 438 438 ?   ?   ?   A . n 
A 1 439 GLU 439 439 ?   ?   ?   A . n 
A 1 440 GLU 440 440 ?   ?   ?   A . n 
A 1 441 ASP 441 441 ?   ?   ?   A . n 
A 1 442 GLY 442 442 ?   ?   ?   A . n 
A 1 443 GLU 443 443 ?   ?   ?   A . n 
A 1 444 SER 444 444 ?   ?   ?   A . n 
A 1 445 ASP 445 445 ?   ?   ?   A . n 
A 1 446 THR 446 446 ?   ?   ?   A . n 
A 1 447 GLU 447 447 ?   ?   ?   A . n 
A 1 448 LYS 448 448 ?   ?   ?   A . n 
A 1 449 ASP 449 449 ?   ?   ?   A . n 
A 1 450 SER 450 450 ?   ?   ?   A . n 
A 1 451 GLY 451 451 ?   ?   ?   A . n 
A 1 452 SER 452 452 ?   ?   ?   A . n 
A 1 453 GLN 453 453 ?   ?   ?   A . n 
A 1 454 VAL 454 454 ?   ?   ?   A . n 
A 1 455 GLU 455 455 ?   ?   ?   A . n 
A 1 456 GLU 456 456 ?   ?   ?   A . n 
A 1 457 ASP 457 457 ?   ?   ?   A . n 
A 1 458 THR 458 458 ?   ?   ?   A . n 
A 1 459 SER 459 459 ?   ?   ?   A . n 
A 1 460 CYS 460 460 ?   ?   ?   A . n 
A 1 461 SER 461 461 ?   ?   ?   A . n 
A 1 462 ASP 462 462 ?   ?   ?   A . n 
A 1 463 SER 463 463 ?   ?   ?   A . n 
A 1 464 LYS 464 464 ?   ?   ?   A . n 
A 1 465 THR 465 465 ?   ?   ?   A . n 
A 1 466 LEU 466 466 ?   ?   ?   A . n 
A 1 467 CYS 467 467 ?   ?   ?   A . n 
A 1 468 THR 468 468 ?   ?   ?   A . n 
A 1 469 GLN 469 469 ?   ?   ?   A . n 
A 1 470 ASP 470 470 ?   ?   ?   A . n 
A 1 471 SER 471 471 ?   ?   ?   A . n 
A 1 472 GLU 472 472 ?   ?   ?   A . n 
A 1 473 SER 473 473 ?   ?   ?   A . n 
A 1 474 THR 474 474 ?   ?   ?   A . n 
A 1 475 GLU 475 475 ?   ?   ?   A . n 
A 1 476 ILE 476 476 ?   ?   ?   A . n 
A 1 477 PRO 477 477 ?   ?   ?   A . n 
A 1 478 LEU 478 478 ?   ?   ?   A . n 
A 1 479 ASP 479 479 ?   ?   ?   A . n 
A 1 480 GLU 480 480 ?   ?   ?   A . n 
A 1 481 GLN 481 481 ?   ?   ?   A . n 
A 1 482 VAL 482 482 ?   ?   ?   A . n 
A 1 483 GLU 483 483 ?   ?   ?   A . n 
A 1 484 GLU 484 484 ?   ?   ?   A . n 
A 1 485 GLU 485 485 ?   ?   ?   A . n 
A 1 486 ALA 486 486 ?   ?   ?   A . n 
A 1 487 VAL 487 487 ?   ?   ?   A . n 
A 1 488 GLY 488 488 ?   ?   ?   A . n 
A 1 489 GLU 489 489 ?   ?   ?   A . n 
A 1 490 GLU 490 490 ?   ?   ?   A . n 
A 1 491 GLU 491 491 ?   ?   ?   A . n 
A 1 492 GLU 492 492 ?   ?   ?   A . n 
A 1 493 SER 493 493 ?   ?   ?   A . n 
A 1 494 GLN 494 494 ?   ?   ?   A . n 
A 1 495 PRO 495 495 ?   ?   ?   A . n 
A 1 496 GLU 496 496 ?   ?   ?   A . n 
A 1 497 ALA 497 497 ?   ?   ?   A . n 
A 1 498 CYS 498 498 ?   ?   ?   A . n 
A 1 499 VAL 499 499 ?   ?   ?   A . n 
A 1 500 ILE 500 500 ?   ?   ?   A . n 
A 1 501 ASP 501 501 ?   ?   ?   A . n 
A 1 502 ASP 502 502 ?   ?   ?   A . n 
A 1 503 ARG 503 503 ?   ?   ?   A . n 
A 1 504 SER 504 504 ?   ?   ?   A . n 
A 1 505 PRO 505 505 ?   ?   ?   A . n 
A 1 506 ASP 506 506 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   ALA 2   2   ?   ?   ?   B . n 
B 1 3   SER 3   3   ?   ?   ?   B . n 
B 1 4   ASN 4   4   ?   ?   ?   B . n 
B 1 5   LYS 5   5   ?   ?   ?   B . n 
B 1 6   PHE 6   6   ?   ?   ?   B . n 
B 1 7   LYS 7   7   ?   ?   ?   B . n 
B 1 8   ARG 8   8   ?   ?   ?   B . n 
B 1 9   MET 9   9   ?   ?   ?   B . n 
B 1 10  LEU 10  10  ?   ?   ?   B . n 
B 1 11  ASN 11  11  ?   ?   ?   B . n 
B 1 12  ARG 12  12  ?   ?   ?   B . n 
B 1 13  GLU 13  13  ?   ?   ?   B . n 
B 1 14  LEU 14  14  ?   ?   ?   B . n 
B 1 15  THR 15  15  ?   ?   ?   B . n 
B 1 16  HIS 16  16  ?   ?   ?   B . n 
B 1 17  LEU 17  17  ?   ?   ?   B . n 
B 1 18  SER 18  18  ?   ?   ?   B . n 
B 1 19  GLU 19  19  ?   ?   ?   B . n 
B 1 20  MET 20  20  ?   ?   ?   B . n 
B 1 21  SER 21  21  ?   ?   ?   B . n 
B 1 22  ARG 22  22  ?   ?   ?   B . n 
B 1 23  SER 23  23  ?   ?   ?   B . n 
B 1 24  GLY 24  24  ?   ?   ?   B . n 
B 1 25  ASN 25  25  ?   ?   ?   B . n 
B 1 26  GLN 26  26  ?   ?   ?   B . n 
B 1 27  VAL 27  27  ?   ?   ?   B . n 
B 1 28  SER 28  28  ?   ?   ?   B . n 
B 1 29  GLU 29  29  ?   ?   ?   B . n 
B 1 30  PHE 30  30  ?   ?   ?   B . n 
B 1 31  ILE 31  31  ?   ?   ?   B . n 
B 1 32  SER 32  32  ?   ?   ?   B . n 
B 1 33  ASN 33  33  ?   ?   ?   B . n 
B 1 34  THR 34  34  ?   ?   ?   B . n 
B 1 35  PHE 35  35  ?   ?   ?   B . n 
B 1 36  LEU 36  36  ?   ?   ?   B . n 
B 1 37  ASP 37  37  ?   ?   ?   B . n 
B 1 38  LYS 38  38  ?   ?   ?   B . n 
B 1 39  GLN 39  39  ?   ?   ?   B . n 
B 1 40  HIS 40  40  ?   ?   ?   B . n 
B 1 41  GLU 41  41  ?   ?   ?   B . n 
B 1 42  VAL 42  42  ?   ?   ?   B . n 
B 1 43  GLU 43  43  ?   ?   ?   B . n 
B 1 44  ILE 44  44  ?   ?   ?   B . n 
B 1 45  PRO 45  45  ?   ?   ?   B . n 
B 1 46  SER 46  46  ?   ?   ?   B . n 
B 1 47  PRO 47  47  ?   ?   ?   B . n 
B 1 48  THR 48  48  ?   ?   ?   B . n 
B 1 49  GLN 49  49  ?   ?   ?   B . n 
B 1 50  LYS 50  50  ?   ?   ?   B . n 
B 1 51  GLU 51  51  ?   ?   ?   B . n 
B 1 52  LYS 52  52  ?   ?   ?   B . n 
B 1 53  GLU 53  53  ?   ?   ?   B . n 
B 1 54  LYS 54  54  ?   ?   ?   B . n 
B 1 55  LYS 55  55  ?   ?   ?   B . n 
B 1 56  LYS 56  56  ?   ?   ?   B . n 
B 1 57  ARG 57  57  ?   ?   ?   B . n 
B 1 58  PRO 58  58  ?   ?   ?   B . n 
B 1 59  MET 59  59  ?   ?   ?   B . n 
B 1 60  SER 60  60  ?   ?   ?   B . n 
B 1 61  GLN 61  61  ?   ?   ?   B . n 
B 1 62  ILE 62  62  ?   ?   ?   B . n 
B 1 63  SER 63  63  ?   ?   ?   B . n 
B 1 64  GLY 64  64  ?   ?   ?   B . n 
B 1 65  VAL 65  65  ?   ?   ?   B . n 
B 1 66  LYS 66  66  ?   ?   ?   B . n 
B 1 67  LYS 67  67  ?   ?   ?   B . n 
B 1 68  LEU 68  68  ?   ?   ?   B . n 
B 1 69  MET 69  69  ?   ?   ?   B . n 
B 1 70  HIS 70  70  ?   ?   ?   B . n 
B 1 71  SER 71  71  ?   ?   ?   B . n 
B 1 72  SER 72  72  ?   ?   ?   B . n 
B 1 73  SER 73  73  ?   ?   ?   B . n 
B 1 74  LEU 74  74  ?   ?   ?   B . n 
B 1 75  THR 75  75  ?   ?   ?   B . n 
B 1 76  ASN 76  76  ?   ?   ?   B . n 
B 1 77  SER 77  77  ?   ?   ?   B . n 
B 1 78  SER 78  78  ?   ?   ?   B . n 
B 1 79  ILE 79  79  ?   ?   ?   B . n 
B 1 80  PRO 80  80  ?   ?   ?   B . n 
B 1 81  ARG 81  81  ?   ?   ?   B . n 
B 1 82  PHE 82  82  ?   ?   ?   B . n 
B 1 83  GLY 83  83  ?   ?   ?   B . n 
B 1 84  VAL 84  84  ?   ?   ?   B . n 
B 1 85  LYS 85  85  ?   ?   ?   B . n 
B 1 86  THR 86  86  ?   ?   ?   B . n 
B 1 87  GLU 87  87  ?   ?   ?   B . n 
B 1 88  GLN 88  88  ?   ?   ?   B . n 
B 1 89  GLU 89  89  ?   ?   ?   B . n 
B 1 90  ASP 90  90  90  ASP ASP B . n 
B 1 91  VAL 91  91  91  VAL VAL B . n 
B 1 92  LEU 92  92  92  LEU LEU B . n 
B 1 93  ALA 93  93  93  ALA ALA B . n 
B 1 94  LYS 94  94  94  LYS LYS B . n 
B 1 95  GLU 95  95  95  GLU GLU B . n 
B 1 96  LEU 96  96  96  LEU LEU B . n 
B 1 97  GLU 97  97  97  GLU GLU B . n 
B 1 98  ASP 98  98  98  ASP ASP B . n 
B 1 99  VAL 99  99  99  VAL VAL B . n 
B 1 100 ASN 100 100 100 ASN ASN B . n 
B 1 101 LYS 101 101 101 LYS LYS B . n 
B 1 102 TRP 102 102 102 TRP TRP B . n 
B 1 103 GLY 103 103 103 GLY GLY B . n 
B 1 104 LEU 104 104 104 LEU LEU B . n 
B 1 105 HIS 105 105 105 HIS HIS B . n 
B 1 106 VAL 106 106 106 VAL VAL B . n 
B 1 107 PHE 107 107 107 PHE PHE B . n 
B 1 108 ARG 108 108 108 ARG ARG B . n 
B 1 109 ILE 109 109 109 ILE ILE B . n 
B 1 110 ALA 110 110 110 ALA ALA B . n 
B 1 111 GLU 111 111 111 GLU GLU B . n 
B 1 112 LEU 112 112 112 LEU LEU B . n 
B 1 113 SER 113 113 113 SER SER B . n 
B 1 114 GLY 114 114 114 GLY GLY B . n 
B 1 115 ASN 115 115 115 ASN ASN B . n 
B 1 116 ARG 116 116 116 ARG ARG B . n 
B 1 117 PRO 117 117 117 PRO PRO B . n 
B 1 118 LEU 118 118 118 LEU LEU B . n 
B 1 119 THR 119 119 119 THR THR B . n 
B 1 120 VAL 120 120 120 VAL VAL B . n 
B 1 121 ILE 121 121 121 ILE ILE B . n 
B 1 122 MET 122 122 122 MET MET B . n 
B 1 123 HIS 123 123 123 HIS HIS B . n 
B 1 124 THR 124 124 124 THR THR B . n 
B 1 125 ILE 125 125 125 ILE ILE B . n 
B 1 126 PHE 126 126 126 PHE PHE B . n 
B 1 127 GLN 127 127 127 GLN GLN B . n 
B 1 128 GLU 128 128 128 GLU GLU B . n 
B 1 129 ARG 129 129 129 ARG ARG B . n 
B 1 130 ASP 130 130 130 ASP ASP B . n 
B 1 131 LEU 131 131 131 LEU LEU B . n 
B 1 132 LEU 132 132 132 LEU LEU B . n 
B 1 133 LYS 133 133 133 LYS LYS B . n 
B 1 134 THR 134 134 134 THR THR B . n 
B 1 135 PHE 135 135 135 PHE PHE B . n 
B 1 136 LYS 136 136 136 LYS LYS B . n 
B 1 137 ILE 137 137 137 ILE ILE B . n 
B 1 138 PRO 138 138 138 PRO PRO B . n 
B 1 139 VAL 139 139 139 VAL VAL B . n 
B 1 140 ASP 140 140 140 ASP ASP B . n 
B 1 141 THR 141 141 141 THR THR B . n 
B 1 142 LEU 142 142 142 LEU LEU B . n 
B 1 143 ILE 143 143 143 ILE ILE B . n 
B 1 144 THR 144 144 144 THR THR B . n 
B 1 145 TYR 145 145 145 TYR TYR B . n 
B 1 146 LEU 146 146 146 LEU LEU B . n 
B 1 147 MET 147 147 147 MET MET B . n 
B 1 148 THR 148 148 148 THR THR B . n 
B 1 149 LEU 149 149 149 LEU LEU B . n 
B 1 150 GLU 150 150 150 GLU GLU B . n 
B 1 151 ASP 151 151 151 ASP ASP B . n 
B 1 152 HIS 152 152 152 HIS HIS B . n 
B 1 153 TYR 153 153 153 TYR TYR B . n 
B 1 154 HIS 154 154 154 HIS HIS B . n 
B 1 155 ALA 155 155 155 ALA ALA B . n 
B 1 156 ASP 156 156 156 ASP ASP B . n 
B 1 157 VAL 157 157 157 VAL VAL B . n 
B 1 158 ALA 158 158 158 ALA ALA B . n 
B 1 159 TYR 159 159 159 TYR TYR B . n 
B 1 160 HIS 160 160 160 HIS HIS B . n 
B 1 161 ASN 161 161 161 ASN ASN B . n 
B 1 162 ASN 162 162 162 ASN ASN B . n 
B 1 163 ILE 163 163 163 ILE ILE B . n 
B 1 164 HIS 164 164 164 HIS HIS B . n 
B 1 165 ALA 165 165 165 ALA ALA B . n 
B 1 166 ALA 166 166 166 ALA ALA B . n 
B 1 167 ASP 167 167 167 ASP ASP B . n 
B 1 168 VAL 168 168 168 VAL VAL B . n 
B 1 169 VAL 169 169 169 VAL VAL B . n 
B 1 170 GLN 170 170 170 GLN GLN B . n 
B 1 171 SER 171 171 171 SER SER B . n 
B 1 172 THR 172 172 172 THR THR B . n 
B 1 173 HIS 173 173 173 HIS HIS B . n 
B 1 174 VAL 174 174 174 VAL VAL B . n 
B 1 175 LEU 175 175 175 LEU LEU B . n 
B 1 176 LEU 176 176 176 LEU LEU B . n 
B 1 177 SER 177 177 177 SER SER B . n 
B 1 178 THR 178 178 178 THR THR B . n 
B 1 179 PRO 179 179 179 PRO PRO B . n 
B 1 180 ALA 180 180 180 ALA ALA B . n 
B 1 181 LEU 181 181 181 LEU LEU B . n 
B 1 182 GLU 182 182 182 GLU GLU B . n 
B 1 183 ALA 183 183 183 ALA ALA B . n 
B 1 184 VAL 184 184 184 VAL VAL B . n 
B 1 185 PHE 185 185 185 PHE PHE B . n 
B 1 186 THR 186 186 186 THR THR B . n 
B 1 187 ASP 187 187 187 ASP ASP B . n 
B 1 188 LEU 188 188 188 LEU LEU B . n 
B 1 189 GLU 189 189 189 GLU GLU B . n 
B 1 190 ILE 190 190 190 ILE ILE B . n 
B 1 191 LEU 191 191 191 LEU LEU B . n 
B 1 192 ALA 192 192 192 ALA ALA B . n 
B 1 193 ALA 193 193 193 ALA ALA B . n 
B 1 194 ILE 194 194 194 ILE ILE B . n 
B 1 195 PHE 195 195 195 PHE PHE B . n 
B 1 196 ALA 196 196 196 ALA ALA B . n 
B 1 197 SER 197 197 197 SER SER B . n 
B 1 198 ALA 198 198 198 ALA ALA B . n 
B 1 199 ILE 199 199 199 ILE ILE B . n 
B 1 200 HIS 200 200 200 HIS HIS B . n 
B 1 201 ASP 201 201 201 ASP ASP B . n 
B 1 202 VAL 202 202 202 VAL VAL B . n 
B 1 203 ASP 203 203 203 ASP ASP B . n 
B 1 204 HIS 204 204 204 HIS HIS B . n 
B 1 205 PRO 205 205 205 PRO PRO B . n 
B 1 206 GLY 206 206 206 GLY GLY B . n 
B 1 207 VAL 207 207 207 VAL VAL B . n 
B 1 208 SER 208 208 208 SER SER B . n 
B 1 209 ASN 209 209 209 ASN ASN B . n 
B 1 210 GLN 210 210 210 GLN GLN B . n 
B 1 211 PHE 211 211 211 PHE PHE B . n 
B 1 212 LEU 212 212 212 LEU LEU B . n 
B 1 213 ILE 213 213 213 ILE ILE B . n 
B 1 214 ASN 214 214 214 ASN ASN B . n 
B 1 215 THR 215 215 215 THR THR B . n 
B 1 216 ASN 216 216 216 ASN ASN B . n 
B 1 217 SER 217 217 217 SER SER B . n 
B 1 218 GLU 218 218 218 GLU GLU B . n 
B 1 219 LEU 219 219 219 LEU LEU B . n 
B 1 220 ALA 220 220 220 ALA ALA B . n 
B 1 221 LEU 221 221 221 LEU LEU B . n 
B 1 222 MET 222 222 222 MET MET B . n 
B 1 223 TYR 223 223 223 TYR TYR B . n 
B 1 224 ASN 224 224 224 ASN ASN B . n 
B 1 225 ASP 225 225 225 ASP ASP B . n 
B 1 226 SER 226 226 226 SER SER B . n 
B 1 227 SER 227 227 227 SER SER B . n 
B 1 228 VAL 228 228 228 VAL VAL B . n 
B 1 229 LEU 229 229 229 LEU LEU B . n 
B 1 230 GLU 230 230 230 GLU GLU B . n 
B 1 231 ASN 231 231 231 ASN ASN B . n 
B 1 232 HIS 232 232 232 HIS HIS B . n 
B 1 233 HIS 233 233 233 HIS HIS B . n 
B 1 234 LEU 234 234 234 LEU LEU B . n 
B 1 235 ALA 235 235 235 ALA ALA B . n 
B 1 236 VAL 236 236 236 VAL VAL B . n 
B 1 237 GLY 237 237 237 GLY GLY B . n 
B 1 238 PHE 238 238 238 PHE PHE B . n 
B 1 239 LYS 239 239 239 LYS LYS B . n 
B 1 240 LEU 240 240 240 LEU LEU B . n 
B 1 241 LEU 241 241 241 LEU LEU B . n 
B 1 242 GLN 242 242 242 GLN GLN B . n 
B 1 243 GLU 243 243 243 GLU GLU B . n 
B 1 244 GLU 244 244 244 GLU GLU B . n 
B 1 245 ASN 245 245 245 ASN ASN B . n 
B 1 246 CYS 246 246 246 CYS CYS B . n 
B 1 247 ASP 247 247 247 ASP ASP B . n 
B 1 248 ILE 248 248 248 ILE ILE B . n 
B 1 249 PHE 249 249 249 PHE PHE B . n 
B 1 250 GLN 250 250 250 GLN GLN B . n 
B 1 251 ASN 251 251 251 ASN ASN B . n 
B 1 252 LEU 252 252 252 LEU LEU B . n 
B 1 253 THR 253 253 253 THR THR B . n 
B 1 254 LYS 254 254 254 LYS LYS B . n 
B 1 255 LYS 255 255 255 LYS LYS B . n 
B 1 256 GLN 256 256 256 GLN GLN B . n 
B 1 257 ARG 257 257 257 ARG ARG B . n 
B 1 258 GLN 258 258 258 GLN GLN B . n 
B 1 259 SER 259 259 259 SER SER B . n 
B 1 260 LEU 260 260 260 LEU LEU B . n 
B 1 261 ARG 261 261 261 ARG ARG B . n 
B 1 262 LYS 262 262 262 LYS LYS B . n 
B 1 263 MET 263 263 263 MET MET B . n 
B 1 264 VAL 264 264 264 VAL VAL B . n 
B 1 265 ILE 265 265 265 ILE ILE B . n 
B 1 266 ASP 266 266 266 ASP ASP B . n 
B 1 267 ILE 267 267 267 ILE ILE B . n 
B 1 268 VAL 268 268 268 VAL VAL B . n 
B 1 269 LEU 269 269 269 LEU LEU B . n 
B 1 270 ALA 270 270 270 ALA ALA B . n 
B 1 271 THR 271 271 271 THR THR B . n 
B 1 272 ASP 272 272 272 ASP ASP B . n 
B 1 273 MET 273 273 273 MET MET B . n 
B 1 274 SER 274 274 274 SER SER B . n 
B 1 275 LYS 275 275 275 LYS LYS B . n 
B 1 276 HIS 276 276 276 HIS HIS B . n 
B 1 277 MET 277 277 277 MET MET B . n 
B 1 278 ASN 278 278 278 ASN ASN B . n 
B 1 279 LEU 279 279 279 LEU LEU B . n 
B 1 280 LEU 280 280 280 LEU LEU B . n 
B 1 281 ALA 281 281 281 ALA ALA B . n 
B 1 282 ASP 282 282 282 ASP ASP B . n 
B 1 283 LEU 283 283 283 LEU LEU B . n 
B 1 284 LYS 284 284 284 LYS LYS B . n 
B 1 285 THR 285 285 285 THR THR B . n 
B 1 286 MET 286 286 286 MET MET B . n 
B 1 287 VAL 287 287 287 VAL VAL B . n 
B 1 288 GLU 288 288 288 GLU GLU B . n 
B 1 289 THR 289 289 289 THR THR B . n 
B 1 290 LYS 290 290 290 LYS LYS B . n 
B 1 291 LYS 291 291 291 LYS LYS B . n 
B 1 292 VAL 292 292 292 VAL VAL B . n 
B 1 293 THR 293 293 293 THR THR B . n 
B 1 294 SER 294 294 294 SER SER B . n 
B 1 295 SER 295 295 295 SER SER B . n 
B 1 296 GLY 296 296 296 GLY GLY B . n 
B 1 297 VAL 297 297 297 VAL VAL B . n 
B 1 298 LEU 298 298 298 LEU LEU B . n 
B 1 299 LEU 299 299 299 LEU LEU B . n 
B 1 300 LEU 300 300 300 LEU LEU B . n 
B 1 301 ASP 301 301 301 ASP ASP B . n 
B 1 302 ASN 302 302 302 ASN ASN B . n 
B 1 303 TYR 303 303 303 TYR TYR B . n 
B 1 304 SER 304 304 304 SER SER B . n 
B 1 305 ASP 305 305 305 ASP ASP B . n 
B 1 306 ARG 306 306 306 ARG ARG B . n 
B 1 307 ILE 307 307 307 ILE ILE B . n 
B 1 308 GLN 308 308 308 GLN GLN B . n 
B 1 309 VAL 309 309 309 VAL VAL B . n 
B 1 310 LEU 310 310 310 LEU LEU B . n 
B 1 311 GLN 311 311 311 GLN GLN B . n 
B 1 312 ASN 312 312 312 ASN ASN B . n 
B 1 313 MET 313 313 313 MET MET B . n 
B 1 314 VAL 314 314 314 VAL VAL B . n 
B 1 315 HIS 315 315 315 HIS HIS B . n 
B 1 316 CYS 316 316 316 CYS CYS B . n 
B 1 317 ALA 317 317 317 ALA ALA B . n 
B 1 318 ASP 318 318 318 ASP ASP B . n 
B 1 319 LEU 319 319 319 LEU LEU B . n 
B 1 320 SER 320 320 320 SER SER B . n 
B 1 321 ASN 321 321 321 ASN ASN B . n 
B 1 322 PRO 322 322 322 PRO PRO B . n 
B 1 323 THR 323 323 323 THR THR B . n 
B 1 324 LYS 324 324 324 LYS LYS B . n 
B 1 325 PRO 325 325 325 PRO PRO B . n 
B 1 326 LEU 326 326 326 LEU LEU B . n 
B 1 327 GLN 327 327 327 GLN GLN B . n 
B 1 328 LEU 328 328 328 LEU LEU B . n 
B 1 329 TYR 329 329 329 TYR TYR B . n 
B 1 330 ARG 330 330 330 ARG ARG B . n 
B 1 331 GLN 331 331 331 GLN GLN B . n 
B 1 332 TRP 332 332 332 TRP TRP B . n 
B 1 333 THR 333 333 333 THR THR B . n 
B 1 334 ASP 334 334 334 ASP ASP B . n 
B 1 335 ARG 335 335 335 ARG ARG B . n 
B 1 336 ILE 336 336 336 ILE ILE B . n 
B 1 337 MET 337 337 337 MET MET B . n 
B 1 338 GLU 338 338 338 GLU GLU B . n 
B 1 339 GLU 339 339 339 GLU GLU B . n 
B 1 340 PHE 340 340 340 PHE PHE B . n 
B 1 341 PHE 341 341 341 PHE PHE B . n 
B 1 342 ARG 342 342 342 ARG ARG B . n 
B 1 343 GLN 343 343 343 GLN GLN B . n 
B 1 344 GLY 344 344 344 GLY GLY B . n 
B 1 345 ASP 345 345 345 ASP ASP B . n 
B 1 346 ARG 346 346 346 ARG ARG B . n 
B 1 347 GLU 347 347 347 GLU GLU B . n 
B 1 348 ARG 348 348 348 ARG ARG B . n 
B 1 349 GLU 349 349 349 GLU GLU B . n 
B 1 350 ARG 350 350 350 ARG ARG B . n 
B 1 351 GLY 351 351 351 GLY GLY B . n 
B 1 352 MET 352 352 352 MET MET B . n 
B 1 353 GLU 353 353 353 GLU GLU B . n 
B 1 354 ILE 354 354 354 ILE ILE B . n 
B 1 355 SER 355 355 355 SER SER B . n 
B 1 356 PRO 356 356 356 PRO PRO B . n 
B 1 357 MET 357 357 357 MET MET B . n 
B 1 358 CYS 358 358 358 CYS CYS B . n 
B 1 359 ASP 359 359 359 ASP ASP B . n 
B 1 360 LYS 360 360 360 LYS LYS B . n 
B 1 361 HIS 361 361 361 HIS HIS B . n 
B 1 362 ASN 362 362 362 ASN ASN B . n 
B 1 363 ALA 363 363 363 ALA ALA B . n 
B 1 364 SER 364 364 364 SER SER B . n 
B 1 365 VAL 365 365 365 VAL VAL B . n 
B 1 366 GLU 366 366 366 GLU GLU B . n 
B 1 367 LYS 367 367 367 LYS LYS B . n 
B 1 368 SER 368 368 368 SER SER B . n 
B 1 369 GLN 369 369 369 GLN GLN B . n 
B 1 370 VAL 370 370 370 VAL VAL B . n 
B 1 371 GLY 371 371 371 GLY GLY B . n 
B 1 372 PHE 372 372 372 PHE PHE B . n 
B 1 373 ILE 373 373 373 ILE ILE B . n 
B 1 374 ASP 374 374 374 ASP ASP B . n 
B 1 375 TYR 375 375 375 TYR TYR B . n 
B 1 376 ILE 376 376 376 ILE ILE B . n 
B 1 377 VAL 377 377 377 VAL VAL B . n 
B 1 378 HIS 378 378 378 HIS HIS B . n 
B 1 379 PRO 379 379 379 PRO PRO B . n 
B 1 380 LEU 380 380 380 LEU LEU B . n 
B 1 381 TRP 381 381 381 TRP TRP B . n 
B 1 382 GLU 382 382 382 GLU GLU B . n 
B 1 383 THR 383 383 383 THR THR B . n 
B 1 384 TRP 384 384 384 TRP TRP B . n 
B 1 385 ALA 385 385 385 ALA ALA B . n 
B 1 386 ASP 386 386 386 ASP ASP B . n 
B 1 387 LEU 387 387 387 LEU LEU B . n 
B 1 388 VAL 388 388 388 VAL VAL B . n 
B 1 389 HIS 389 389 389 HIS HIS B . n 
B 1 390 PRO 390 390 390 PRO PRO B . n 
B 1 391 ASP 391 391 391 ASP ASP B . n 
B 1 392 ALA 392 392 392 ALA ALA B . n 
B 1 393 GLN 393 393 393 GLN GLN B . n 
B 1 394 ASP 394 394 394 ASP ASP B . n 
B 1 395 ILE 395 395 395 ILE ILE B . n 
B 1 396 LEU 396 396 396 LEU LEU B . n 
B 1 397 ASP 397 397 397 ASP ASP B . n 
B 1 398 THR 398 398 398 THR THR B . n 
B 1 399 LEU 399 399 399 LEU LEU B . n 
B 1 400 GLU 400 400 400 GLU GLU B . n 
B 1 401 ASP 401 401 401 ASP ASP B . n 
B 1 402 ASN 402 402 402 ASN ASN B . n 
B 1 403 ARG 403 403 403 ARG ARG B . n 
B 1 404 GLU 404 404 404 GLU GLU B . n 
B 1 405 TRP 405 405 405 TRP TRP B . n 
B 1 406 TYR 406 406 406 TYR TYR B . n 
B 1 407 GLN 407 407 407 GLN GLN B . n 
B 1 408 SER 408 408 408 SER SER B . n 
B 1 409 THR 409 409 409 THR THR B . n 
B 1 410 ILE 410 410 410 ILE ILE B . n 
B 1 411 PRO 411 411 ?   ?   ?   B . n 
B 1 412 GLN 412 412 ?   ?   ?   B . n 
B 1 413 SER 413 413 ?   ?   ?   B . n 
B 1 414 PRO 414 414 ?   ?   ?   B . n 
B 1 415 SER 415 415 ?   ?   ?   B . n 
B 1 416 PRO 416 416 ?   ?   ?   B . n 
B 1 417 ALA 417 417 ?   ?   ?   B . n 
B 1 418 PRO 418 418 ?   ?   ?   B . n 
B 1 419 ASP 419 419 ?   ?   ?   B . n 
B 1 420 ASP 420 420 ?   ?   ?   B . n 
B 1 421 PRO 421 421 ?   ?   ?   B . n 
B 1 422 GLU 422 422 ?   ?   ?   B . n 
B 1 423 GLU 423 423 ?   ?   ?   B . n 
B 1 424 GLY 424 424 ?   ?   ?   B . n 
B 1 425 ARG 425 425 ?   ?   ?   B . n 
B 1 426 GLN 426 426 ?   ?   ?   B . n 
B 1 427 GLY 427 427 ?   ?   ?   B . n 
B 1 428 GLN 428 428 ?   ?   ?   B . n 
B 1 429 THR 429 429 ?   ?   ?   B . n 
B 1 430 GLU 430 430 ?   ?   ?   B . n 
B 1 431 LYS 431 431 ?   ?   ?   B . n 
B 1 432 PHE 432 432 ?   ?   ?   B . n 
B 1 433 GLN 433 433 ?   ?   ?   B . n 
B 1 434 PHE 434 434 ?   ?   ?   B . n 
B 1 435 GLU 435 435 ?   ?   ?   B . n 
B 1 436 LEU 436 436 ?   ?   ?   B . n 
B 1 437 THR 437 437 ?   ?   ?   B . n 
B 1 438 LEU 438 438 ?   ?   ?   B . n 
B 1 439 GLU 439 439 ?   ?   ?   B . n 
B 1 440 GLU 440 440 ?   ?   ?   B . n 
B 1 441 ASP 441 441 ?   ?   ?   B . n 
B 1 442 GLY 442 442 ?   ?   ?   B . n 
B 1 443 GLU 443 443 ?   ?   ?   B . n 
B 1 444 SER 444 444 ?   ?   ?   B . n 
B 1 445 ASP 445 445 ?   ?   ?   B . n 
B 1 446 THR 446 446 ?   ?   ?   B . n 
B 1 447 GLU 447 447 ?   ?   ?   B . n 
B 1 448 LYS 448 448 ?   ?   ?   B . n 
B 1 449 ASP 449 449 ?   ?   ?   B . n 
B 1 450 SER 450 450 ?   ?   ?   B . n 
B 1 451 GLY 451 451 ?   ?   ?   B . n 
B 1 452 SER 452 452 ?   ?   ?   B . n 
B 1 453 GLN 453 453 ?   ?   ?   B . n 
B 1 454 VAL 454 454 ?   ?   ?   B . n 
B 1 455 GLU 455 455 ?   ?   ?   B . n 
B 1 456 GLU 456 456 ?   ?   ?   B . n 
B 1 457 ASP 457 457 ?   ?   ?   B . n 
B 1 458 THR 458 458 ?   ?   ?   B . n 
B 1 459 SER 459 459 ?   ?   ?   B . n 
B 1 460 CYS 460 460 ?   ?   ?   B . n 
B 1 461 SER 461 461 ?   ?   ?   B . n 
B 1 462 ASP 462 462 ?   ?   ?   B . n 
B 1 463 SER 463 463 ?   ?   ?   B . n 
B 1 464 LYS 464 464 ?   ?   ?   B . n 
B 1 465 THR 465 465 ?   ?   ?   B . n 
B 1 466 LEU 466 466 ?   ?   ?   B . n 
B 1 467 CYS 467 467 ?   ?   ?   B . n 
B 1 468 THR 468 468 ?   ?   ?   B . n 
B 1 469 GLN 469 469 ?   ?   ?   B . n 
B 1 470 ASP 470 470 ?   ?   ?   B . n 
B 1 471 SER 471 471 ?   ?   ?   B . n 
B 1 472 GLU 472 472 ?   ?   ?   B . n 
B 1 473 SER 473 473 ?   ?   ?   B . n 
B 1 474 THR 474 474 ?   ?   ?   B . n 
B 1 475 GLU 475 475 ?   ?   ?   B . n 
B 1 476 ILE 476 476 ?   ?   ?   B . n 
B 1 477 PRO 477 477 ?   ?   ?   B . n 
B 1 478 LEU 478 478 ?   ?   ?   B . n 
B 1 479 ASP 479 479 ?   ?   ?   B . n 
B 1 480 GLU 480 480 ?   ?   ?   B . n 
B 1 481 GLN 481 481 ?   ?   ?   B . n 
B 1 482 VAL 482 482 ?   ?   ?   B . n 
B 1 483 GLU 483 483 ?   ?   ?   B . n 
B 1 484 GLU 484 484 ?   ?   ?   B . n 
B 1 485 GLU 485 485 ?   ?   ?   B . n 
B 1 486 ALA 486 486 ?   ?   ?   B . n 
B 1 487 VAL 487 487 ?   ?   ?   B . n 
B 1 488 GLY 488 488 ?   ?   ?   B . n 
B 1 489 GLU 489 489 ?   ?   ?   B . n 
B 1 490 GLU 490 490 ?   ?   ?   B . n 
B 1 491 GLU 491 491 ?   ?   ?   B . n 
B 1 492 GLU 492 492 ?   ?   ?   B . n 
B 1 493 SER 493 493 ?   ?   ?   B . n 
B 1 494 GLN 494 494 ?   ?   ?   B . n 
B 1 495 PRO 495 495 ?   ?   ?   B . n 
B 1 496 GLU 496 496 ?   ?   ?   B . n 
B 1 497 ALA 497 497 ?   ?   ?   B . n 
B 1 498 CYS 498 498 ?   ?   ?   B . n 
B 1 499 VAL 499 499 ?   ?   ?   B . n 
B 1 500 ILE 500 500 ?   ?   ?   B . n 
B 1 501 ASP 501 501 ?   ?   ?   B . n 
B 1 502 ASP 502 502 ?   ?   ?   B . n 
B 1 503 ARG 503 503 ?   ?   ?   B . n 
B 1 504 SER 504 504 ?   ?   ?   B . n 
B 1 505 PRO 505 505 ?   ?   ?   B . n 
B 1 506 ASP 506 506 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1D8P 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1D8P 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 ZN    1   601 1   ZN    ZN  A . 
D 3 MG    1   602 1   MG    MG  A . 
E 4 A1D8P 1   603 1   A1D8P LX1 A . 
F 2 ZN    1   601 2   ZN    ZN  B . 
G 3 MG    1   602 2   MG    MG  B . 
H 4 A1D8P 1   603 2   A1D8P LX1 B . 
I 5 HOH   1   701 114 HOH   HOH A . 
I 5 HOH   2   702 130 HOH   HOH A . 
I 5 HOH   3   703 263 HOH   HOH A . 
I 5 HOH   4   704 169 HOH   HOH A . 
I 5 HOH   5   705 194 HOH   HOH A . 
I 5 HOH   6   706 177 HOH   HOH A . 
I 5 HOH   7   707 123 HOH   HOH A . 
I 5 HOH   8   708 80  HOH   HOH A . 
I 5 HOH   9   709 180 HOH   HOH A . 
I 5 HOH   10  710 112 HOH   HOH A . 
I 5 HOH   11  711 266 HOH   HOH A . 
I 5 HOH   12  712 258 HOH   HOH A . 
I 5 HOH   13  713 137 HOH   HOH A . 
I 5 HOH   14  714 179 HOH   HOH A . 
I 5 HOH   15  715 85  HOH   HOH A . 
I 5 HOH   16  716 67  HOH   HOH A . 
I 5 HOH   17  717 251 HOH   HOH A . 
I 5 HOH   18  718 146 HOH   HOH A . 
I 5 HOH   19  719 64  HOH   HOH A . 
I 5 HOH   20  720 5   HOH   HOH A . 
I 5 HOH   21  721 136 HOH   HOH A . 
I 5 HOH   22  722 46  HOH   HOH A . 
I 5 HOH   23  723 218 HOH   HOH A . 
I 5 HOH   24  724 190 HOH   HOH A . 
I 5 HOH   25  725 44  HOH   HOH A . 
I 5 HOH   26  726 129 HOH   HOH A . 
I 5 HOH   27  727 202 HOH   HOH A . 
I 5 HOH   28  728 32  HOH   HOH A . 
I 5 HOH   29  729 262 HOH   HOH A . 
I 5 HOH   30  730 15  HOH   HOH A . 
I 5 HOH   31  731 66  HOH   HOH A . 
I 5 HOH   32  732 221 HOH   HOH A . 
I 5 HOH   33  733 99  HOH   HOH A . 
I 5 HOH   34  734 233 HOH   HOH A . 
I 5 HOH   35  735 94  HOH   HOH A . 
I 5 HOH   36  736 118 HOH   HOH A . 
I 5 HOH   37  737 43  HOH   HOH A . 
I 5 HOH   38  738 200 HOH   HOH A . 
I 5 HOH   39  739 27  HOH   HOH A . 
I 5 HOH   40  740 61  HOH   HOH A . 
I 5 HOH   41  741 117 HOH   HOH A . 
I 5 HOH   42  742 59  HOH   HOH A . 
I 5 HOH   43  743 140 HOH   HOH A . 
I 5 HOH   44  744 207 HOH   HOH A . 
I 5 HOH   45  745 134 HOH   HOH A . 
I 5 HOH   46  746 91  HOH   HOH A . 
I 5 HOH   47  747 188 HOH   HOH A . 
I 5 HOH   48  748 212 HOH   HOH A . 
I 5 HOH   49  749 182 HOH   HOH A . 
I 5 HOH   50  750 48  HOH   HOH A . 
I 5 HOH   51  751 51  HOH   HOH A . 
I 5 HOH   52  752 38  HOH   HOH A . 
I 5 HOH   53  753 41  HOH   HOH A . 
I 5 HOH   54  754 160 HOH   HOH A . 
I 5 HOH   55  755 113 HOH   HOH A . 
I 5 HOH   56  756 164 HOH   HOH A . 
I 5 HOH   57  757 50  HOH   HOH A . 
I 5 HOH   58  758 4   HOH   HOH A . 
I 5 HOH   59  759 18  HOH   HOH A . 
I 5 HOH   60  760 105 HOH   HOH A . 
I 5 HOH   61  761 186 HOH   HOH A . 
I 5 HOH   62  762 209 HOH   HOH A . 
I 5 HOH   63  763 185 HOH   HOH A . 
I 5 HOH   64  764 96  HOH   HOH A . 
I 5 HOH   65  765 268 HOH   HOH A . 
I 5 HOH   66  766 246 HOH   HOH A . 
I 5 HOH   67  767 22  HOH   HOH A . 
I 5 HOH   68  768 144 HOH   HOH A . 
I 5 HOH   69  769 159 HOH   HOH A . 
I 5 HOH   70  770 269 HOH   HOH A . 
I 5 HOH   71  771 79  HOH   HOH A . 
I 5 HOH   72  772 20  HOH   HOH A . 
I 5 HOH   73  773 126 HOH   HOH A . 
I 5 HOH   74  774 2   HOH   HOH A . 
I 5 HOH   75  775 236 HOH   HOH A . 
I 5 HOH   76  776 240 HOH   HOH A . 
I 5 HOH   77  777 102 HOH   HOH A . 
I 5 HOH   78  778 132 HOH   HOH A . 
I 5 HOH   79  779 75  HOH   HOH A . 
I 5 HOH   80  780 77  HOH   HOH A . 
I 5 HOH   81  781 104 HOH   HOH A . 
I 5 HOH   82  782 110 HOH   HOH A . 
I 5 HOH   83  783 17  HOH   HOH A . 
I 5 HOH   84  784 34  HOH   HOH A . 
I 5 HOH   85  785 36  HOH   HOH A . 
I 5 HOH   86  786 220 HOH   HOH A . 
I 5 HOH   87  787 63  HOH   HOH A . 
I 5 HOH   88  788 69  HOH   HOH A . 
I 5 HOH   89  789 6   HOH   HOH A . 
I 5 HOH   90  790 89  HOH   HOH A . 
I 5 HOH   91  791 141 HOH   HOH A . 
I 5 HOH   92  792 74  HOH   HOH A . 
I 5 HOH   93  793 76  HOH   HOH A . 
I 5 HOH   94  794 189 HOH   HOH A . 
I 5 HOH   95  795 90  HOH   HOH A . 
I 5 HOH   96  796 261 HOH   HOH A . 
I 5 HOH   97  797 72  HOH   HOH A . 
I 5 HOH   98  798 122 HOH   HOH A . 
I 5 HOH   99  799 154 HOH   HOH A . 
I 5 HOH   100 800 39  HOH   HOH A . 
I 5 HOH   101 801 37  HOH   HOH A . 
I 5 HOH   102 802 265 HOH   HOH A . 
I 5 HOH   103 803 23  HOH   HOH A . 
I 5 HOH   104 804 151 HOH   HOH A . 
I 5 HOH   105 805 239 HOH   HOH A . 
I 5 HOH   106 806 86  HOH   HOH A . 
I 5 HOH   107 807 205 HOH   HOH A . 
I 5 HOH   108 808 197 HOH   HOH A . 
I 5 HOH   109 809 30  HOH   HOH A . 
I 5 HOH   110 810 234 HOH   HOH A . 
I 5 HOH   111 811 165 HOH   HOH A . 
I 5 HOH   112 812 264 HOH   HOH A . 
I 5 HOH   113 813 16  HOH   HOH A . 
I 5 HOH   114 814 87  HOH   HOH A . 
I 5 HOH   115 815 237 HOH   HOH A . 
I 5 HOH   116 816 106 HOH   HOH A . 
I 5 HOH   117 817 245 HOH   HOH A . 
I 5 HOH   118 818 255 HOH   HOH A . 
I 5 HOH   119 819 115 HOH   HOH A . 
I 5 HOH   120 820 1   HOH   HOH A . 
I 5 HOH   121 821 210 HOH   HOH A . 
I 5 HOH   122 822 60  HOH   HOH A . 
I 5 HOH   123 823 232 HOH   HOH A . 
I 5 HOH   124 824 25  HOH   HOH A . 
I 5 HOH   125 825 162 HOH   HOH A . 
I 5 HOH   126 826 203 HOH   HOH A . 
I 5 HOH   127 827 138 HOH   HOH A . 
I 5 HOH   128 828 148 HOH   HOH A . 
I 5 HOH   129 829 55  HOH   HOH A . 
I 5 HOH   130 830 195 HOH   HOH A . 
I 5 HOH   131 831 147 HOH   HOH A . 
I 5 HOH   132 832 107 HOH   HOH A . 
I 5 HOH   133 833 58  HOH   HOH A . 
I 5 HOH   134 834 101 HOH   HOH A . 
I 5 HOH   135 835 108 HOH   HOH A . 
I 5 HOH   136 836 267 HOH   HOH A . 
I 5 HOH   137 837 253 HOH   HOH A . 
I 5 HOH   138 838 52  HOH   HOH A . 
I 5 HOH   139 839 244 HOH   HOH A . 
I 5 HOH   140 840 100 HOH   HOH A . 
I 5 HOH   141 841 238 HOH   HOH A . 
I 5 HOH   142 842 145 HOH   HOH A . 
I 5 HOH   143 843 49  HOH   HOH A . 
I 5 HOH   144 844 181 HOH   HOH A . 
I 5 HOH   145 845 3   HOH   HOH A . 
I 5 HOH   146 846 95  HOH   HOH A . 
I 5 HOH   147 847 231 HOH   HOH A . 
I 5 HOH   148 848 252 HOH   HOH A . 
I 5 HOH   149 849 174 HOH   HOH A . 
I 5 HOH   150 850 71  HOH   HOH A . 
I 5 HOH   151 851 150 HOH   HOH A . 
I 5 HOH   152 852 68  HOH   HOH A . 
I 5 HOH   153 853 250 HOH   HOH A . 
I 5 HOH   154 854 271 HOH   HOH A . 
I 5 HOH   155 855 228 HOH   HOH A . 
I 5 HOH   156 856 208 HOH   HOH A . 
I 5 HOH   157 857 224 HOH   HOH A . 
I 5 HOH   158 858 131 HOH   HOH A . 
I 5 HOH   159 859 219 HOH   HOH A . 
I 5 HOH   160 860 152 HOH   HOH A . 
I 5 HOH   161 861 270 HOH   HOH A . 
I 5 HOH   162 862 158 HOH   HOH A . 
I 5 HOH   163 863 172 HOH   HOH A . 
I 5 HOH   164 864 173 HOH   HOH A . 
I 5 HOH   165 865 225 HOH   HOH A . 
I 5 HOH   166 866 135 HOH   HOH A . 
I 5 HOH   167 867 175 HOH   HOH A . 
J 5 HOH   1   701 178 HOH   HOH B . 
J 5 HOH   2   702 28  HOH   HOH B . 
J 5 HOH   3   703 247 HOH   HOH B . 
J 5 HOH   4   704 230 HOH   HOH B . 
J 5 HOH   5   705 111 HOH   HOH B . 
J 5 HOH   6   706 103 HOH   HOH B . 
J 5 HOH   7   707 12  HOH   HOH B . 
J 5 HOH   8   708 161 HOH   HOH B . 
J 5 HOH   9   709 125 HOH   HOH B . 
J 5 HOH   10  710 259 HOH   HOH B . 
J 5 HOH   11  711 187 HOH   HOH B . 
J 5 HOH   12  712 227 HOH   HOH B . 
J 5 HOH   13  713 10  HOH   HOH B . 
J 5 HOH   14  714 33  HOH   HOH B . 
J 5 HOH   15  715 88  HOH   HOH B . 
J 5 HOH   16  716 163 HOH   HOH B . 
J 5 HOH   17  717 215 HOH   HOH B . 
J 5 HOH   18  718 83  HOH   HOH B . 
J 5 HOH   19  719 45  HOH   HOH B . 
J 5 HOH   20  720 213 HOH   HOH B . 
J 5 HOH   21  721 193 HOH   HOH B . 
J 5 HOH   22  722 47  HOH   HOH B . 
J 5 HOH   23  723 54  HOH   HOH B . 
J 5 HOH   24  724 29  HOH   HOH B . 
J 5 HOH   25  725 139 HOH   HOH B . 
J 5 HOH   26  726 65  HOH   HOH B . 
J 5 HOH   27  727 53  HOH   HOH B . 
J 5 HOH   28  728 82  HOH   HOH B . 
J 5 HOH   29  729 133 HOH   HOH B . 
J 5 HOH   30  730 120 HOH   HOH B . 
J 5 HOH   31  731 128 HOH   HOH B . 
J 5 HOH   32  732 21  HOH   HOH B . 
J 5 HOH   33  733 256 HOH   HOH B . 
J 5 HOH   34  734 109 HOH   HOH B . 
J 5 HOH   35  735 257 HOH   HOH B . 
J 5 HOH   36  736 73  HOH   HOH B . 
J 5 HOH   37  737 40  HOH   HOH B . 
J 5 HOH   38  738 166 HOH   HOH B . 
J 5 HOH   39  739 199 HOH   HOH B . 
J 5 HOH   40  740 8   HOH   HOH B . 
J 5 HOH   41  741 70  HOH   HOH B . 
J 5 HOH   42  742 156 HOH   HOH B . 
J 5 HOH   43  743 142 HOH   HOH B . 
J 5 HOH   44  744 121 HOH   HOH B . 
J 5 HOH   45  745 167 HOH   HOH B . 
J 5 HOH   46  746 11  HOH   HOH B . 
J 5 HOH   47  747 206 HOH   HOH B . 
J 5 HOH   48  748 176 HOH   HOH B . 
J 5 HOH   49  749 143 HOH   HOH B . 
J 5 HOH   50  750 62  HOH   HOH B . 
J 5 HOH   51  751 19  HOH   HOH B . 
J 5 HOH   52  752 13  HOH   HOH B . 
J 5 HOH   53  753 24  HOH   HOH B . 
J 5 HOH   54  754 14  HOH   HOH B . 
J 5 HOH   55  755 35  HOH   HOH B . 
J 5 HOH   56  756 183 HOH   HOH B . 
J 5 HOH   57  757 204 HOH   HOH B . 
J 5 HOH   58  758 93  HOH   HOH B . 
J 5 HOH   59  759 31  HOH   HOH B . 
J 5 HOH   60  760 260 HOH   HOH B . 
J 5 HOH   61  761 78  HOH   HOH B . 
J 5 HOH   62  762 57  HOH   HOH B . 
J 5 HOH   63  763 42  HOH   HOH B . 
J 5 HOH   64  764 26  HOH   HOH B . 
J 5 HOH   65  765 211 HOH   HOH B . 
J 5 HOH   66  766 7   HOH   HOH B . 
J 5 HOH   67  767 241 HOH   HOH B . 
J 5 HOH   68  768 81  HOH   HOH B . 
J 5 HOH   69  769 97  HOH   HOH B . 
J 5 HOH   70  770 198 HOH   HOH B . 
J 5 HOH   71  771 149 HOH   HOH B . 
J 5 HOH   72  772 153 HOH   HOH B . 
J 5 HOH   73  773 157 HOH   HOH B . 
J 5 HOH   74  774 170 HOH   HOH B . 
J 5 HOH   75  775 127 HOH   HOH B . 
J 5 HOH   76  776 243 HOH   HOH B . 
J 5 HOH   77  777 191 HOH   HOH B . 
J 5 HOH   78  778 254 HOH   HOH B . 
J 5 HOH   79  779 249 HOH   HOH B . 
J 5 HOH   80  780 217 HOH   HOH B . 
J 5 HOH   81  781 196 HOH   HOH B . 
J 5 HOH   82  782 192 HOH   HOH B . 
J 5 HOH   83  783 116 HOH   HOH B . 
J 5 HOH   84  784 155 HOH   HOH B . 
J 5 HOH   85  785 201 HOH   HOH B . 
J 5 HOH   86  786 248 HOH   HOH B . 
J 5 HOH   87  787 98  HOH   HOH B . 
J 5 HOH   88  788 84  HOH   HOH B . 
J 5 HOH   89  789 216 HOH   HOH B . 
J 5 HOH   90  790 229 HOH   HOH B . 
J 5 HOH   91  791 9   HOH   HOH B . 
J 5 HOH   92  792 168 HOH   HOH B . 
J 5 HOH   93  793 119 HOH   HOH B . 
J 5 HOH   94  794 184 HOH   HOH B . 
J 5 HOH   95  795 242 HOH   HOH B . 
J 5 HOH   96  796 235 HOH   HOH B . 
J 5 HOH   97  797 92  HOH   HOH B . 
J 5 HOH   98  798 124 HOH   HOH B . 
J 5 HOH   99  799 223 HOH   HOH B . 
J 5 HOH   100 800 214 HOH   HOH B . 
J 5 HOH   101 801 171 HOH   HOH B . 
J 5 HOH   102 802 56  HOH   HOH B . 
J 5 HOH   103 803 226 HOH   HOH B . 
J 5 HOH   104 804 222 HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? V8        1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.10_2155 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? 171.39.46 3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZQU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     58.475 
_cell.length_a_esd                 ? 
_cell.length_b                     80.619 
_cell.length_b_esd                 ? 
_cell.length_c                     163.765 
_cell.length_c_esd                 ? 
_cell.volume                       772017.439 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZQU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZQU 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.67 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          26.38 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M HEPES (pH 7.4), 0.1M MgCl2, 15% PEG3350, 10% isopropanol, 25% ethylene glycol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU HyPix-3000' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-03-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.5418 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.5418 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          20.0423603012 
_reflns.entry_id                                       8ZQU 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.0 
_reflns.d_resolution_low                               23.6449 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     53059 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.061 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.0 
_reflns_shell.d_res_low                                     2.1 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.3 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3827 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               2.8 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.1 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.38 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.1806979271 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZQU 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00004554556 
_refine.ls_d_res_low                             23.6448946434 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     53001 
_refine.ls_number_reflns_R_free                  2669 
_refine.ls_number_reflns_R_work                  50332 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.7234138632 
_refine.ls_percent_reflns_R_free                 5.03575404238 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.208116912168 
_refine.ls_R_factor_R_free                       0.242599170545 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.206263307542 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35152087284 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               NONE 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      5WQA 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 24.2478002829 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.241215608104 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00004554556 
_refine_hist.d_res_low                        23.6448946434 
_refine_hist.number_atoms_solvent             271 
_refine_hist.number_atoms_total               5552 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        5221 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         60 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.00761592695236 ? 5389 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.88715345402    ? 7324 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0473603350084  ? 837  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.00529306251057 ? 956  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.0019658552    ? 3270 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00005 2.0364  . . 130 2583 98.6545454545 . . . . 0.28238055199  . . . . . . . . . . . 0.328279454341 
'X-RAY DIFFRACTION' 2.0364  2.0755  . . 126 2642 99.4252873563 . . . . 0.240032691236 . . . . . . . . . . . 0.283014750516 
'X-RAY DIFFRACTION' 2.0755  2.1179  . . 124 2603 99.4529540481 . . . . 0.243651223247 . . . . . . . . . . . 0.24789893167  
'X-RAY DIFFRACTION' 2.1179  2.1639  . . 140 2627 99.5323741007 . . . . 0.235786495873 . . . . . . . . . . . 0.300935184949 
'X-RAY DIFFRACTION' 2.1639  2.2142  . . 130 2596 99.7438712038 . . . . 0.230039332506 . . . . . . . . . . . 0.291791315466 
'X-RAY DIFFRACTION' 2.2142  2.2695  . . 136 2602 99.8905508938 . . . . 0.2224458694   . . . . . . . . . . . 0.277817304838 
'X-RAY DIFFRACTION' 2.2695  2.3308  . . 145 2647 99.9641962048 . . . . 0.219295864009 . . . . . . . . . . . 0.318967298282 
'X-RAY DIFFRACTION' 2.3308  2.3994  . . 141 2600 99.8906705539 . . . . 0.214150417788 . . . . . . . . . . . 0.279913949391 
'X-RAY DIFFRACTION' 2.3994  2.4767  . . 135 2635 99.9639119451 . . . . 0.212113648491 . . . . . . . . . . . 0.233939540402 
'X-RAY DIFFRACTION' 2.4767  2.5651  . . 158 2632 99.9641705482 . . . . 0.213491982094 . . . . . . . . . . . 0.285410679102 
'X-RAY DIFFRACTION' 2.5651  2.6677  . . 148 2626 100.0         . . . . 0.215218333679 . . . . . . . . . . . 0.256953179804 
'X-RAY DIFFRACTION' 2.6677  2.789   . . 134 2671 100.0         . . . . 0.213079008577 . . . . . . . . . . . 0.274129399893 
'X-RAY DIFFRACTION' 2.789   2.9357  . . 140 2639 99.964028777  . . . . 0.214029533934 . . . . . . . . . . . 0.236702495014 
'X-RAY DIFFRACTION' 2.9357  3.1193  . . 139 2660 99.9642857143 . . . . 0.219186496228 . . . . . . . . . . . 0.270176188826 
'X-RAY DIFFRACTION' 3.1193  3.3595  . . 143 2670 100.0         . . . . 0.213800352861 . . . . . . . . . . . 0.29513389387  
'X-RAY DIFFRACTION' 3.3595  3.6964  . . 137 2688 100.0         . . . . 0.205014235483 . . . . . . . . . . . 0.229513499803 
'X-RAY DIFFRACTION' 3.6964  4.2287  . . 149 2679 100.0         . . . . 0.182656535325 . . . . . . . . . . . 0.215104884711 
'X-RAY DIFFRACTION' 4.2287  5.3177  . . 160 2723 99.896049896  . . . . 0.167488407051 . . . . . . . . . . . 0.159461970884 
'X-RAY DIFFRACTION' 5.3177  23.6448 . . 154 2809 98.667998668  . . . . 0.175422803398 . . . . . . . . . . . 0.186652084961 
# 
_struct.entry_id                     8ZQU 
_struct.title                        'The crystal structure of PDE4D with isoaurostatin derivatives 2-6' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZQU 
_struct_keywords.text            'Inhibitor, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 2 ? 
G N N 3 ? 
H N N 4 ? 
I N N 5 ? 
J N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PDE4D_HUMAN 
_struct_ref.pdbx_db_accession          Q08499 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIP
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL
LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLS
NPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE
QVEEEAVGEEEESQPEACVIDDRSPD
;
_struct_ref.pdbx_align_begin           303 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZQU A 1 ? 506 ? Q08499 303 ? 808 ? 1 506 
2 1 8ZQU B 1 ? 506 ? Q08499 303 ? 808 ? 1 506 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1960  ? 
1 MORE         -105  ? 
1 'SSA (A^2)'  27660 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 87  ? GLU A 97  ? GLU A 87  GLU A 97  1 ? 11 
HELX_P HELX_P2  AA2 HIS A 105 ? SER A 113 ? HIS A 105 SER A 113 1 ? 9  
HELX_P HELX_P3  AA3 ARG A 116 ? ARG A 129 ? ARG A 116 ARG A 129 1 ? 14 
HELX_P HELX_P4  AA4 ASP A 130 ? LYS A 136 ? ASP A 130 LYS A 136 1 ? 7  
HELX_P HELX_P5  AA5 PRO A 138 ? HIS A 152 ? PRO A 138 HIS A 152 1 ? 15 
HELX_P HELX_P6  AA6 ASN A 161 ? SER A 177 ? ASN A 161 SER A 177 1 ? 17 
HELX_P HELX_P7  AA7 THR A 178 ? GLU A 182 ? THR A 178 GLU A 182 5 ? 5  
HELX_P HELX_P8  AA8 THR A 186 ? HIS A 200 ? THR A 186 HIS A 200 1 ? 15 
HELX_P HELX_P9  AA9 SER A 208 ? THR A 215 ? SER A 208 THR A 215 1 ? 8  
HELX_P HELX_P10 AB1 SER A 217 ? ASN A 224 ? SER A 217 ASN A 224 1 ? 8  
HELX_P HELX_P11 AB2 SER A 227 ? LEU A 240 ? SER A 227 LEU A 240 1 ? 14 
HELX_P HELX_P12 AB3 LEU A 241 ? GLU A 243 ? LEU A 241 GLU A 243 5 ? 3  
HELX_P HELX_P13 AB4 THR A 253 ? ALA A 270 ? THR A 253 ALA A 270 1 ? 18 
HELX_P HELX_P14 AB5 THR A 271 ? SER A 274 ? THR A 271 SER A 274 5 ? 4  
HELX_P HELX_P15 AB6 LYS A 275 ? THR A 289 ? LYS A 275 THR A 289 1 ? 15 
HELX_P HELX_P16 AB7 ASN A 302 ? LEU A 319 ? ASN A 302 LEU A 319 1 ? 18 
HELX_P HELX_P17 AB8 SER A 320 ? LYS A 324 ? SER A 320 LYS A 324 5 ? 5  
HELX_P HELX_P18 AB9 PRO A 325 ? ARG A 350 ? PRO A 325 ARG A 350 1 ? 26 
HELX_P HELX_P19 AC1 ASP A 359 ? ALA A 363 ? ASP A 359 ALA A 363 5 ? 5  
HELX_P HELX_P20 AC2 SER A 364 ? ILE A 376 ? SER A 364 ILE A 376 1 ? 13 
HELX_P HELX_P21 AC3 ILE A 376 ? VAL A 388 ? ILE A 376 VAL A 388 1 ? 13 
HELX_P HELX_P22 AC4 ALA A 392 ? THR A 409 ? ALA A 392 THR A 409 1 ? 18 
HELX_P HELX_P23 AC5 VAL B 91  ? LEU B 96  ? VAL B 91  LEU B 96  1 ? 6  
HELX_P HELX_P24 AC6 GLU B 97  ? VAL B 99  ? GLU B 97  VAL B 99  5 ? 3  
HELX_P HELX_P25 AC7 HIS B 105 ? SER B 113 ? HIS B 105 SER B 113 1 ? 9  
HELX_P HELX_P26 AC8 ARG B 116 ? ASP B 130 ? ARG B 116 ASP B 130 1 ? 15 
HELX_P HELX_P27 AC9 ASP B 130 ? PHE B 135 ? ASP B 130 PHE B 135 1 ? 6  
HELX_P HELX_P28 AD1 PRO B 138 ? HIS B 152 ? PRO B 138 HIS B 152 1 ? 15 
HELX_P HELX_P29 AD2 ASN B 161 ? SER B 177 ? ASN B 161 SER B 177 1 ? 17 
HELX_P HELX_P30 AD3 THR B 178 ? GLU B 182 ? THR B 178 GLU B 182 5 ? 5  
HELX_P HELX_P31 AD4 THR B 186 ? HIS B 200 ? THR B 186 HIS B 200 1 ? 15 
HELX_P HELX_P32 AD5 SER B 208 ? THR B 215 ? SER B 208 THR B 215 1 ? 8  
HELX_P HELX_P33 AD6 SER B 217 ? ASN B 224 ? SER B 217 ASN B 224 1 ? 8  
HELX_P HELX_P34 AD7 SER B 227 ? LEU B 240 ? SER B 227 LEU B 240 1 ? 14 
HELX_P HELX_P35 AD8 LEU B 241 ? GLU B 243 ? LEU B 241 GLU B 243 5 ? 3  
HELX_P HELX_P36 AD9 THR B 253 ? ALA B 270 ? THR B 253 ALA B 270 1 ? 18 
HELX_P HELX_P37 AE1 THR B 271 ? SER B 274 ? THR B 271 SER B 274 5 ? 4  
HELX_P HELX_P38 AE2 LYS B 275 ? THR B 289 ? LYS B 275 THR B 289 1 ? 15 
HELX_P HELX_P39 AE3 ASN B 302 ? LEU B 319 ? ASN B 302 LEU B 319 1 ? 18 
HELX_P HELX_P40 AE4 SER B 320 ? LYS B 324 ? SER B 320 LYS B 324 5 ? 5  
HELX_P HELX_P41 AE5 PRO B 325 ? ARG B 350 ? PRO B 325 ARG B 350 1 ? 26 
HELX_P HELX_P42 AE6 SER B 364 ? ILE B 376 ? SER B 364 ILE B 376 1 ? 13 
HELX_P HELX_P43 AE7 ILE B 376 ? VAL B 388 ? ILE B 376 VAL B 388 1 ? 13 
HELX_P HELX_P44 AE8 ALA B 392 ? THR B 409 ? ALA B 392 THR B 409 1 ? 18 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 164 NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 164 A ZN  601 1_555 ? ? ? ? ? ? ? 2.187 ? ? 
metalc2  metalc ? ? A HIS 200 NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 200 A ZN  601 1_555 ? ? ? ? ? ? ? 2.242 ? ? 
metalc3  metalc ? ? A ASP 201 OD2 ? ? ? 1_555 C ZN  . ZN ? ? A ASP 201 A ZN  601 1_555 ? ? ? ? ? ? ? 2.063 ? ? 
metalc4  metalc ? ? A ASP 201 OD1 ? ? ? 1_555 D MG  . MG ? ? A ASP 201 A MG  602 1_555 ? ? ? ? ? ? ? 2.041 ? ? 
metalc5  metalc ? ? A ASP 318 OD1 ? ? ? 1_555 C ZN  . ZN ? ? A ASP 318 A ZN  601 1_555 ? ? ? ? ? ? ? 2.190 ? ? 
metalc6  metalc ? ? C ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  601 A HOH 774 1_555 ? ? ? ? ? ? ? 2.006 ? ? 
metalc7  metalc ? ? C ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  601 A HOH 820 1_555 ? ? ? ? ? ? ? 2.127 ? ? 
metalc8  metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 720 1_555 ? ? ? ? ? ? ? 2.192 ? ? 
metalc9  metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 758 1_555 ? ? ? ? ? ? ? 2.135 ? ? 
metalc10 metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 774 1_555 ? ? ? ? ? ? ? 2.122 ? ? 
metalc11 metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 789 1_555 ? ? ? ? ? ? ? 2.101 ? ? 
metalc12 metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 845 1_555 ? ? ? ? ? ? ? 2.120 ? ? 
metalc13 metalc ? ? B HIS 164 NE2 ? ? ? 1_555 F ZN  . ZN ? ? B HIS 164 B ZN  601 1_555 ? ? ? ? ? ? ? 2.270 ? ? 
metalc14 metalc ? ? B HIS 200 NE2 ? ? ? 1_555 F ZN  . ZN ? ? B HIS 200 B ZN  601 1_555 ? ? ? ? ? ? ? 2.213 ? ? 
metalc15 metalc ? ? B ASP 201 OD2 ? ? ? 1_555 F ZN  . ZN ? ? B ASP 201 B ZN  601 1_555 ? ? ? ? ? ? ? 2.046 ? ? 
metalc16 metalc ? ? B ASP 201 OD1 ? ? ? 1_555 G MG  . MG ? ? B ASP 201 B MG  602 1_555 ? ? ? ? ? ? ? 2.125 ? ? 
metalc17 metalc ? ? B ASP 318 OD1 ? ? ? 1_555 F ZN  . ZN ? ? B ASP 318 B ZN  601 1_555 ? ? ? ? ? ? ? 2.131 ? ? 
metalc18 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? B ZN  601 B HOH 740 1_555 ? ? ? ? ? ? ? 2.134 ? ? 
metalc19 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? B ZN  601 B HOH 766 1_555 ? ? ? ? ? ? ? 2.285 ? ? 
metalc20 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 707 1_555 ? ? ? ? ? ? ? 2.154 ? ? 
metalc21 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 713 1_555 ? ? ? ? ? ? ? 2.177 ? ? 
metalc22 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 740 1_555 ? ? ? ? ? ? ? 1.954 ? ? 
metalc23 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 746 1_555 ? ? ? ? ? ? ? 2.252 ? ? 
metalc24 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 791 1_555 ? ? ? ? ? ? ? 2.106 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 NE2 ? A HIS 200 ? A HIS 200 ? 1_555 91.8  ? 
2  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD2 ? A ASP 201 ? A ASP 201 ? 1_555 90.1  ? 
3  NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD2 ? A ASP 201 ? A ASP 201 ? 1_555 82.7  ? 
4  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 85.7  ? 
5  NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 89.6  ? 
6  OD2 ? A ASP 201 ? A ASP 201 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 171.1 ? 
7  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 774 ? 1_555 177.0 ? 
8  NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 774 ? 1_555 91.1  ? 
9  OD2 ? A ASP 201 ? A ASP 201 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 774 ? 1_555 89.5  ? 
10 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 774 ? 1_555 95.1  ? 
11 NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 820 ? 1_555 85.0  ? 
12 NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 820 ? 1_555 175.9 ? 
13 OD2 ? A ASP 201 ? A ASP 201 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 820 ? 1_555 99.7  ? 
14 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 820 ? 1_555 87.7  ? 
15 O   ? I HOH .   ? A HOH 774 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 820 ? 1_555 92.1  ? 
16 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 720 ? 1_555 162.3 ? 
17 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 758 ? 1_555 85.0  ? 
18 O   ? I HOH .   ? A HOH 720 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 758 ? 1_555 79.2  ? 
19 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 774 ? 1_555 92.1  ? 
20 O   ? I HOH .   ? A HOH 720 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 774 ? 1_555 96.9  ? 
21 O   ? I HOH .   ? A HOH 758 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 774 ? 1_555 94.7  ? 
22 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 789 ? 1_555 88.0  ? 
23 O   ? I HOH .   ? A HOH 720 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 789 ? 1_555 84.3  ? 
24 O   ? I HOH .   ? A HOH 758 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 789 ? 1_555 90.6  ? 
25 O   ? I HOH .   ? A HOH 774 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 789 ? 1_555 174.7 ? 
26 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 845 ? 1_555 102.0 ? 
27 O   ? I HOH .   ? A HOH 720 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 845 ? 1_555 93.3  ? 
28 O   ? I HOH .   ? A HOH 758 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 845 ? 1_555 171.9 ? 
29 O   ? I HOH .   ? A HOH 774 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 845 ? 1_555 89.2  ? 
30 O   ? I HOH .   ? A HOH 789 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 845 ? 1_555 85.6  ? 
31 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 92.0  ? 
32 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 90.5  ? 
33 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 84.3  ? 
34 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 82.6  ? 
35 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 87.8  ? 
36 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 169.3 ? 
37 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 740 ? 1_555 174.1 ? 
38 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 740 ? 1_555 93.3  ? 
39 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 740 ? 1_555 92.7  ? 
40 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 740 ? 1_555 94.9  ? 
41 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 766 ? 1_555 86.6  ? 
42 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 766 ? 1_555 177.0 ? 
43 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 766 ? 1_555 98.4  ? 
44 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 766 ? 1_555 89.4  ? 
45 O   ? J HOH .   ? B HOH 740 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 766 ? 1_555 88.0  ? 
46 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 707 ? 1_555 165.4 ? 
47 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 713 ? 1_555 82.2  ? 
48 O   ? J HOH .   ? B HOH 707 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 713 ? 1_555 86.1  ? 
49 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 740 ? 1_555 92.1  ? 
50 O   ? J HOH .   ? B HOH 707 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 740 ? 1_555 97.8  ? 
51 O   ? J HOH .   ? B HOH 713 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 740 ? 1_555 96.1  ? 
52 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 746 ? 1_555 83.4  ? 
53 O   ? J HOH .   ? B HOH 707 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 746 ? 1_555 87.8  ? 
54 O   ? J HOH .   ? B HOH 713 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 746 ? 1_555 89.6  ? 
55 O   ? J HOH .   ? B HOH 740 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 746 ? 1_555 172.2 ? 
56 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 791 ? 1_555 96.2  ? 
57 O   ? J HOH .   ? B HOH 707 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 791 ? 1_555 94.5  ? 
58 O   ? J HOH .   ? B HOH 713 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 791 ? 1_555 173.4 ? 
59 O   ? J HOH .   ? B HOH 740 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 791 ? 1_555 90.3  ? 
60 O   ? J HOH .   ? B HOH 746 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 791 ? 1_555 83.8  ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 HIS 389 A . ? HIS 389 A PRO 390 A ? PRO 390 A 1 3.99 
2 HIS 389 B . ? HIS 389 B PRO 390 B ? PRO 390 B 1 6.17 
# 
_pdbx_entry_details.entry_id                   8ZQU 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O   A HOH 714 ? ? O A HOH 847 ? ? 2.07 
2  1 O   A HOH 766 ? ? O B HOH 779 ? ? 2.07 
3  1 OE1 B GLN 331 ? ? O B HOH 701 ? ? 2.08 
4  1 O   A HOH 752 ? ? O A HOH 854 ? ? 2.10 
5  1 O   A HOH 842 ? ? O B HOH 779 ? ? 2.10 
6  1 NE2 B GLN 331 ? ? O B HOH 702 ? ? 2.12 
7  1 O   A LEU 252 ? ? O A HOH 701 ? ? 2.14 
8  1 OG1 A THR 253 ? ? O A HOH 702 ? ? 2.15 
9  1 OD1 B ASP 90  ? ? O B HOH 703 ? ? 2.17 
10 1 O   A HOH 703 ? ? O A HOH 812 ? ? 2.18 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    OE1 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    GLU 
_pdbx_validate_symm_contact.auth_seq_id_1     111 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    OG 
_pdbx_validate_symm_contact.auth_asym_id_2    B 
_pdbx_validate_symm_contact.auth_comp_id_2    SER 
_pdbx_validate_symm_contact.auth_seq_id_2     295 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   3_454 
_pdbx_validate_symm_contact.dist              2.15 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 161 ? ? -124.67 -168.77 
2 1 ALA A 183 ? ? 57.82   18.16   
3 1 ASN A 362 ? ? -156.32 38.50   
4 1 ILE A 376 ? ? -132.85 -62.88  
5 1 ASN B 161 ? ? -126.94 -167.44 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A ALA 2   ? A ALA 2   
3   1 Y 1 A SER 3   ? A SER 3   
4   1 Y 1 A ASN 4   ? A ASN 4   
5   1 Y 1 A LYS 5   ? A LYS 5   
6   1 Y 1 A PHE 6   ? A PHE 6   
7   1 Y 1 A LYS 7   ? A LYS 7   
8   1 Y 1 A ARG 8   ? A ARG 8   
9   1 Y 1 A MET 9   ? A MET 9   
10  1 Y 1 A LEU 10  ? A LEU 10  
11  1 Y 1 A ASN 11  ? A ASN 11  
12  1 Y 1 A ARG 12  ? A ARG 12  
13  1 Y 1 A GLU 13  ? A GLU 13  
14  1 Y 1 A LEU 14  ? A LEU 14  
15  1 Y 1 A THR 15  ? A THR 15  
16  1 Y 1 A HIS 16  ? A HIS 16  
17  1 Y 1 A LEU 17  ? A LEU 17  
18  1 Y 1 A SER 18  ? A SER 18  
19  1 Y 1 A GLU 19  ? A GLU 19  
20  1 Y 1 A MET 20  ? A MET 20  
21  1 Y 1 A SER 21  ? A SER 21  
22  1 Y 1 A ARG 22  ? A ARG 22  
23  1 Y 1 A SER 23  ? A SER 23  
24  1 Y 1 A GLY 24  ? A GLY 24  
25  1 Y 1 A ASN 25  ? A ASN 25  
26  1 Y 1 A GLN 26  ? A GLN 26  
27  1 Y 1 A VAL 27  ? A VAL 27  
28  1 Y 1 A SER 28  ? A SER 28  
29  1 Y 1 A GLU 29  ? A GLU 29  
30  1 Y 1 A PHE 30  ? A PHE 30  
31  1 Y 1 A ILE 31  ? A ILE 31  
32  1 Y 1 A SER 32  ? A SER 32  
33  1 Y 1 A ASN 33  ? A ASN 33  
34  1 Y 1 A THR 34  ? A THR 34  
35  1 Y 1 A PHE 35  ? A PHE 35  
36  1 Y 1 A LEU 36  ? A LEU 36  
37  1 Y 1 A ASP 37  ? A ASP 37  
38  1 Y 1 A LYS 38  ? A LYS 38  
39  1 Y 1 A GLN 39  ? A GLN 39  
40  1 Y 1 A HIS 40  ? A HIS 40  
41  1 Y 1 A GLU 41  ? A GLU 41  
42  1 Y 1 A VAL 42  ? A VAL 42  
43  1 Y 1 A GLU 43  ? A GLU 43  
44  1 Y 1 A ILE 44  ? A ILE 44  
45  1 Y 1 A PRO 45  ? A PRO 45  
46  1 Y 1 A SER 46  ? A SER 46  
47  1 Y 1 A PRO 47  ? A PRO 47  
48  1 Y 1 A THR 48  ? A THR 48  
49  1 Y 1 A GLN 49  ? A GLN 49  
50  1 Y 1 A LYS 50  ? A LYS 50  
51  1 Y 1 A GLU 51  ? A GLU 51  
52  1 Y 1 A LYS 52  ? A LYS 52  
53  1 Y 1 A GLU 53  ? A GLU 53  
54  1 Y 1 A LYS 54  ? A LYS 54  
55  1 Y 1 A LYS 55  ? A LYS 55  
56  1 Y 1 A LYS 56  ? A LYS 56  
57  1 Y 1 A ARG 57  ? A ARG 57  
58  1 Y 1 A PRO 58  ? A PRO 58  
59  1 Y 1 A MET 59  ? A MET 59  
60  1 Y 1 A SER 60  ? A SER 60  
61  1 Y 1 A GLN 61  ? A GLN 61  
62  1 Y 1 A ILE 62  ? A ILE 62  
63  1 Y 1 A SER 63  ? A SER 63  
64  1 Y 1 A GLY 64  ? A GLY 64  
65  1 Y 1 A VAL 65  ? A VAL 65  
66  1 Y 1 A LYS 66  ? A LYS 66  
67  1 Y 1 A LYS 67  ? A LYS 67  
68  1 Y 1 A LEU 68  ? A LEU 68  
69  1 Y 1 A MET 69  ? A MET 69  
70  1 Y 1 A HIS 70  ? A HIS 70  
71  1 Y 1 A SER 71  ? A SER 71  
72  1 Y 1 A SER 72  ? A SER 72  
73  1 Y 1 A SER 73  ? A SER 73  
74  1 Y 1 A LEU 74  ? A LEU 74  
75  1 Y 1 A THR 75  ? A THR 75  
76  1 Y 1 A ASN 76  ? A ASN 76  
77  1 Y 1 A SER 77  ? A SER 77  
78  1 Y 1 A SER 78  ? A SER 78  
79  1 Y 1 A ILE 79  ? A ILE 79  
80  1 Y 1 A PRO 80  ? A PRO 80  
81  1 Y 1 A ARG 81  ? A ARG 81  
82  1 Y 1 A PHE 82  ? A PHE 82  
83  1 Y 1 A GLY 83  ? A GLY 83  
84  1 Y 1 A VAL 84  ? A VAL 84  
85  1 Y 1 A LYS 85  ? A LYS 85  
86  1 Y 1 A THR 86  ? A THR 86  
87  1 Y 1 A PRO 411 ? A PRO 411 
88  1 Y 1 A GLN 412 ? A GLN 412 
89  1 Y 1 A SER 413 ? A SER 413 
90  1 Y 1 A PRO 414 ? A PRO 414 
91  1 Y 1 A SER 415 ? A SER 415 
92  1 Y 1 A PRO 416 ? A PRO 416 
93  1 Y 1 A ALA 417 ? A ALA 417 
94  1 Y 1 A PRO 418 ? A PRO 418 
95  1 Y 1 A ASP 419 ? A ASP 419 
96  1 Y 1 A ASP 420 ? A ASP 420 
97  1 Y 1 A PRO 421 ? A PRO 421 
98  1 Y 1 A GLU 422 ? A GLU 422 
99  1 Y 1 A GLU 423 ? A GLU 423 
100 1 Y 1 A GLY 424 ? A GLY 424 
101 1 Y 1 A ARG 425 ? A ARG 425 
102 1 Y 1 A GLN 426 ? A GLN 426 
103 1 Y 1 A GLY 427 ? A GLY 427 
104 1 Y 1 A GLN 428 ? A GLN 428 
105 1 Y 1 A THR 429 ? A THR 429 
106 1 Y 1 A GLU 430 ? A GLU 430 
107 1 Y 1 A LYS 431 ? A LYS 431 
108 1 Y 1 A PHE 432 ? A PHE 432 
109 1 Y 1 A GLN 433 ? A GLN 433 
110 1 Y 1 A PHE 434 ? A PHE 434 
111 1 Y 1 A GLU 435 ? A GLU 435 
112 1 Y 1 A LEU 436 ? A LEU 436 
113 1 Y 1 A THR 437 ? A THR 437 
114 1 Y 1 A LEU 438 ? A LEU 438 
115 1 Y 1 A GLU 439 ? A GLU 439 
116 1 Y 1 A GLU 440 ? A GLU 440 
117 1 Y 1 A ASP 441 ? A ASP 441 
118 1 Y 1 A GLY 442 ? A GLY 442 
119 1 Y 1 A GLU 443 ? A GLU 443 
120 1 Y 1 A SER 444 ? A SER 444 
121 1 Y 1 A ASP 445 ? A ASP 445 
122 1 Y 1 A THR 446 ? A THR 446 
123 1 Y 1 A GLU 447 ? A GLU 447 
124 1 Y 1 A LYS 448 ? A LYS 448 
125 1 Y 1 A ASP 449 ? A ASP 449 
126 1 Y 1 A SER 450 ? A SER 450 
127 1 Y 1 A GLY 451 ? A GLY 451 
128 1 Y 1 A SER 452 ? A SER 452 
129 1 Y 1 A GLN 453 ? A GLN 453 
130 1 Y 1 A VAL 454 ? A VAL 454 
131 1 Y 1 A GLU 455 ? A GLU 455 
132 1 Y 1 A GLU 456 ? A GLU 456 
133 1 Y 1 A ASP 457 ? A ASP 457 
134 1 Y 1 A THR 458 ? A THR 458 
135 1 Y 1 A SER 459 ? A SER 459 
136 1 Y 1 A CYS 460 ? A CYS 460 
137 1 Y 1 A SER 461 ? A SER 461 
138 1 Y 1 A ASP 462 ? A ASP 462 
139 1 Y 1 A SER 463 ? A SER 463 
140 1 Y 1 A LYS 464 ? A LYS 464 
141 1 Y 1 A THR 465 ? A THR 465 
142 1 Y 1 A LEU 466 ? A LEU 466 
143 1 Y 1 A CYS 467 ? A CYS 467 
144 1 Y 1 A THR 468 ? A THR 468 
145 1 Y 1 A GLN 469 ? A GLN 469 
146 1 Y 1 A ASP 470 ? A ASP 470 
147 1 Y 1 A SER 471 ? A SER 471 
148 1 Y 1 A GLU 472 ? A GLU 472 
149 1 Y 1 A SER 473 ? A SER 473 
150 1 Y 1 A THR 474 ? A THR 474 
151 1 Y 1 A GLU 475 ? A GLU 475 
152 1 Y 1 A ILE 476 ? A ILE 476 
153 1 Y 1 A PRO 477 ? A PRO 477 
154 1 Y 1 A LEU 478 ? A LEU 478 
155 1 Y 1 A ASP 479 ? A ASP 479 
156 1 Y 1 A GLU 480 ? A GLU 480 
157 1 Y 1 A GLN 481 ? A GLN 481 
158 1 Y 1 A VAL 482 ? A VAL 482 
159 1 Y 1 A GLU 483 ? A GLU 483 
160 1 Y 1 A GLU 484 ? A GLU 484 
161 1 Y 1 A GLU 485 ? A GLU 485 
162 1 Y 1 A ALA 486 ? A ALA 486 
163 1 Y 1 A VAL 487 ? A VAL 487 
164 1 Y 1 A GLY 488 ? A GLY 488 
165 1 Y 1 A GLU 489 ? A GLU 489 
166 1 Y 1 A GLU 490 ? A GLU 490 
167 1 Y 1 A GLU 491 ? A GLU 491 
168 1 Y 1 A GLU 492 ? A GLU 492 
169 1 Y 1 A SER 493 ? A SER 493 
170 1 Y 1 A GLN 494 ? A GLN 494 
171 1 Y 1 A PRO 495 ? A PRO 495 
172 1 Y 1 A GLU 496 ? A GLU 496 
173 1 Y 1 A ALA 497 ? A ALA 497 
174 1 Y 1 A CYS 498 ? A CYS 498 
175 1 Y 1 A VAL 499 ? A VAL 499 
176 1 Y 1 A ILE 500 ? A ILE 500 
177 1 Y 1 A ASP 501 ? A ASP 501 
178 1 Y 1 A ASP 502 ? A ASP 502 
179 1 Y 1 A ARG 503 ? A ARG 503 
180 1 Y 1 A SER 504 ? A SER 504 
181 1 Y 1 A PRO 505 ? A PRO 505 
182 1 Y 1 A ASP 506 ? A ASP 506 
183 1 Y 1 B MET 1   ? B MET 1   
184 1 Y 1 B ALA 2   ? B ALA 2   
185 1 Y 1 B SER 3   ? B SER 3   
186 1 Y 1 B ASN 4   ? B ASN 4   
187 1 Y 1 B LYS 5   ? B LYS 5   
188 1 Y 1 B PHE 6   ? B PHE 6   
189 1 Y 1 B LYS 7   ? B LYS 7   
190 1 Y 1 B ARG 8   ? B ARG 8   
191 1 Y 1 B MET 9   ? B MET 9   
192 1 Y 1 B LEU 10  ? B LEU 10  
193 1 Y 1 B ASN 11  ? B ASN 11  
194 1 Y 1 B ARG 12  ? B ARG 12  
195 1 Y 1 B GLU 13  ? B GLU 13  
196 1 Y 1 B LEU 14  ? B LEU 14  
197 1 Y 1 B THR 15  ? B THR 15  
198 1 Y 1 B HIS 16  ? B HIS 16  
199 1 Y 1 B LEU 17  ? B LEU 17  
200 1 Y 1 B SER 18  ? B SER 18  
201 1 Y 1 B GLU 19  ? B GLU 19  
202 1 Y 1 B MET 20  ? B MET 20  
203 1 Y 1 B SER 21  ? B SER 21  
204 1 Y 1 B ARG 22  ? B ARG 22  
205 1 Y 1 B SER 23  ? B SER 23  
206 1 Y 1 B GLY 24  ? B GLY 24  
207 1 Y 1 B ASN 25  ? B ASN 25  
208 1 Y 1 B GLN 26  ? B GLN 26  
209 1 Y 1 B VAL 27  ? B VAL 27  
210 1 Y 1 B SER 28  ? B SER 28  
211 1 Y 1 B GLU 29  ? B GLU 29  
212 1 Y 1 B PHE 30  ? B PHE 30  
213 1 Y 1 B ILE 31  ? B ILE 31  
214 1 Y 1 B SER 32  ? B SER 32  
215 1 Y 1 B ASN 33  ? B ASN 33  
216 1 Y 1 B THR 34  ? B THR 34  
217 1 Y 1 B PHE 35  ? B PHE 35  
218 1 Y 1 B LEU 36  ? B LEU 36  
219 1 Y 1 B ASP 37  ? B ASP 37  
220 1 Y 1 B LYS 38  ? B LYS 38  
221 1 Y 1 B GLN 39  ? B GLN 39  
222 1 Y 1 B HIS 40  ? B HIS 40  
223 1 Y 1 B GLU 41  ? B GLU 41  
224 1 Y 1 B VAL 42  ? B VAL 42  
225 1 Y 1 B GLU 43  ? B GLU 43  
226 1 Y 1 B ILE 44  ? B ILE 44  
227 1 Y 1 B PRO 45  ? B PRO 45  
228 1 Y 1 B SER 46  ? B SER 46  
229 1 Y 1 B PRO 47  ? B PRO 47  
230 1 Y 1 B THR 48  ? B THR 48  
231 1 Y 1 B GLN 49  ? B GLN 49  
232 1 Y 1 B LYS 50  ? B LYS 50  
233 1 Y 1 B GLU 51  ? B GLU 51  
234 1 Y 1 B LYS 52  ? B LYS 52  
235 1 Y 1 B GLU 53  ? B GLU 53  
236 1 Y 1 B LYS 54  ? B LYS 54  
237 1 Y 1 B LYS 55  ? B LYS 55  
238 1 Y 1 B LYS 56  ? B LYS 56  
239 1 Y 1 B ARG 57  ? B ARG 57  
240 1 Y 1 B PRO 58  ? B PRO 58  
241 1 Y 1 B MET 59  ? B MET 59  
242 1 Y 1 B SER 60  ? B SER 60  
243 1 Y 1 B GLN 61  ? B GLN 61  
244 1 Y 1 B ILE 62  ? B ILE 62  
245 1 Y 1 B SER 63  ? B SER 63  
246 1 Y 1 B GLY 64  ? B GLY 64  
247 1 Y 1 B VAL 65  ? B VAL 65  
248 1 Y 1 B LYS 66  ? B LYS 66  
249 1 Y 1 B LYS 67  ? B LYS 67  
250 1 Y 1 B LEU 68  ? B LEU 68  
251 1 Y 1 B MET 69  ? B MET 69  
252 1 Y 1 B HIS 70  ? B HIS 70  
253 1 Y 1 B SER 71  ? B SER 71  
254 1 Y 1 B SER 72  ? B SER 72  
255 1 Y 1 B SER 73  ? B SER 73  
256 1 Y 1 B LEU 74  ? B LEU 74  
257 1 Y 1 B THR 75  ? B THR 75  
258 1 Y 1 B ASN 76  ? B ASN 76  
259 1 Y 1 B SER 77  ? B SER 77  
260 1 Y 1 B SER 78  ? B SER 78  
261 1 Y 1 B ILE 79  ? B ILE 79  
262 1 Y 1 B PRO 80  ? B PRO 80  
263 1 Y 1 B ARG 81  ? B ARG 81  
264 1 Y 1 B PHE 82  ? B PHE 82  
265 1 Y 1 B GLY 83  ? B GLY 83  
266 1 Y 1 B VAL 84  ? B VAL 84  
267 1 Y 1 B LYS 85  ? B LYS 85  
268 1 Y 1 B THR 86  ? B THR 86  
269 1 Y 1 B GLU 87  ? B GLU 87  
270 1 Y 1 B GLN 88  ? B GLN 88  
271 1 Y 1 B GLU 89  ? B GLU 89  
272 1 Y 1 B PRO 411 ? B PRO 411 
273 1 Y 1 B GLN 412 ? B GLN 412 
274 1 Y 1 B SER 413 ? B SER 413 
275 1 Y 1 B PRO 414 ? B PRO 414 
276 1 Y 1 B SER 415 ? B SER 415 
277 1 Y 1 B PRO 416 ? B PRO 416 
278 1 Y 1 B ALA 417 ? B ALA 417 
279 1 Y 1 B PRO 418 ? B PRO 418 
280 1 Y 1 B ASP 419 ? B ASP 419 
281 1 Y 1 B ASP 420 ? B ASP 420 
282 1 Y 1 B PRO 421 ? B PRO 421 
283 1 Y 1 B GLU 422 ? B GLU 422 
284 1 Y 1 B GLU 423 ? B GLU 423 
285 1 Y 1 B GLY 424 ? B GLY 424 
286 1 Y 1 B ARG 425 ? B ARG 425 
287 1 Y 1 B GLN 426 ? B GLN 426 
288 1 Y 1 B GLY 427 ? B GLY 427 
289 1 Y 1 B GLN 428 ? B GLN 428 
290 1 Y 1 B THR 429 ? B THR 429 
291 1 Y 1 B GLU 430 ? B GLU 430 
292 1 Y 1 B LYS 431 ? B LYS 431 
293 1 Y 1 B PHE 432 ? B PHE 432 
294 1 Y 1 B GLN 433 ? B GLN 433 
295 1 Y 1 B PHE 434 ? B PHE 434 
296 1 Y 1 B GLU 435 ? B GLU 435 
297 1 Y 1 B LEU 436 ? B LEU 436 
298 1 Y 1 B THR 437 ? B THR 437 
299 1 Y 1 B LEU 438 ? B LEU 438 
300 1 Y 1 B GLU 439 ? B GLU 439 
301 1 Y 1 B GLU 440 ? B GLU 440 
302 1 Y 1 B ASP 441 ? B ASP 441 
303 1 Y 1 B GLY 442 ? B GLY 442 
304 1 Y 1 B GLU 443 ? B GLU 443 
305 1 Y 1 B SER 444 ? B SER 444 
306 1 Y 1 B ASP 445 ? B ASP 445 
307 1 Y 1 B THR 446 ? B THR 446 
308 1 Y 1 B GLU 447 ? B GLU 447 
309 1 Y 1 B LYS 448 ? B LYS 448 
310 1 Y 1 B ASP 449 ? B ASP 449 
311 1 Y 1 B SER 450 ? B SER 450 
312 1 Y 1 B GLY 451 ? B GLY 451 
313 1 Y 1 B SER 452 ? B SER 452 
314 1 Y 1 B GLN 453 ? B GLN 453 
315 1 Y 1 B VAL 454 ? B VAL 454 
316 1 Y 1 B GLU 455 ? B GLU 455 
317 1 Y 1 B GLU 456 ? B GLU 456 
318 1 Y 1 B ASP 457 ? B ASP 457 
319 1 Y 1 B THR 458 ? B THR 458 
320 1 Y 1 B SER 459 ? B SER 459 
321 1 Y 1 B CYS 460 ? B CYS 460 
322 1 Y 1 B SER 461 ? B SER 461 
323 1 Y 1 B ASP 462 ? B ASP 462 
324 1 Y 1 B SER 463 ? B SER 463 
325 1 Y 1 B LYS 464 ? B LYS 464 
326 1 Y 1 B THR 465 ? B THR 465 
327 1 Y 1 B LEU 466 ? B LEU 466 
328 1 Y 1 B CYS 467 ? B CYS 467 
329 1 Y 1 B THR 468 ? B THR 468 
330 1 Y 1 B GLN 469 ? B GLN 469 
331 1 Y 1 B ASP 470 ? B ASP 470 
332 1 Y 1 B SER 471 ? B SER 471 
333 1 Y 1 B GLU 472 ? B GLU 472 
334 1 Y 1 B SER 473 ? B SER 473 
335 1 Y 1 B THR 474 ? B THR 474 
336 1 Y 1 B GLU 475 ? B GLU 475 
337 1 Y 1 B ILE 476 ? B ILE 476 
338 1 Y 1 B PRO 477 ? B PRO 477 
339 1 Y 1 B LEU 478 ? B LEU 478 
340 1 Y 1 B ASP 479 ? B ASP 479 
341 1 Y 1 B GLU 480 ? B GLU 480 
342 1 Y 1 B GLN 481 ? B GLN 481 
343 1 Y 1 B VAL 482 ? B VAL 482 
344 1 Y 1 B GLU 483 ? B GLU 483 
345 1 Y 1 B GLU 484 ? B GLU 484 
346 1 Y 1 B GLU 485 ? B GLU 485 
347 1 Y 1 B ALA 486 ? B ALA 486 
348 1 Y 1 B VAL 487 ? B VAL 487 
349 1 Y 1 B GLY 488 ? B GLY 488 
350 1 Y 1 B GLU 489 ? B GLU 489 
351 1 Y 1 B GLU 490 ? B GLU 490 
352 1 Y 1 B GLU 491 ? B GLU 491 
353 1 Y 1 B GLU 492 ? B GLU 492 
354 1 Y 1 B SER 493 ? B SER 493 
355 1 Y 1 B GLN 494 ? B GLN 494 
356 1 Y 1 B PRO 495 ? B PRO 495 
357 1 Y 1 B GLU 496 ? B GLU 496 
358 1 Y 1 B ALA 497 ? B ALA 497 
359 1 Y 1 B CYS 498 ? B CYS 498 
360 1 Y 1 B VAL 499 ? B VAL 499 
361 1 Y 1 B ILE 500 ? B ILE 500 
362 1 Y 1 B ASP 501 ? B ASP 501 
363 1 Y 1 B ASP 502 ? B ASP 502 
364 1 Y 1 B ARG 503 ? B ARG 503 
365 1 Y 1 B SER 504 ? B SER 504 
366 1 Y 1 B PRO 505 ? B PRO 505 
367 1 Y 1 B ASP 506 ? B ASP 506 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1D8P C5   C  Y N 1   
A1D8P C4   C  Y N 2   
A1D8P O3   O  N N 3   
A1D8P C2   C  N N 4   
A1D8P O1   O  N N 5   
A1D8P C6   C  N N 6   
A1D8P C7   C  N N 7   
A1D8P C8   C  Y N 8   
A1D8P C9   C  Y N 9   
A1D8P C10  C  Y N 10  
A1D8P C11  C  Y N 11  
A1D8P O12  O  N N 12  
A1D8P C13  C  N N 13  
A1D8P F14  F  N N 14  
A1D8P F15  F  N N 15  
A1D8P C16  C  Y N 16  
A1D8P O17  O  N N 17  
A1D8P C18  C  N N 18  
A1D8P C19  C  N N 19  
A1D8P C20  C  N N 20  
A1D8P C21  C  N N 21  
A1D8P C22  C  N N 22  
A1D8P C23  C  Y N 23  
A1D8P C24  C  Y N 24  
A1D8P C25  C  Y N 25  
A1D8P C26  C  Y N 26  
A1D8P O27  O  N N 27  
A1D8P C28  C  Y N 28  
A1D8P H1   H  N N 29  
A1D8P H2   H  N N 30  
A1D8P H3   H  N N 31  
A1D8P H4   H  N N 32  
A1D8P H5   H  N N 33  
A1D8P H6   H  N N 34  
A1D8P H7   H  N N 35  
A1D8P H8   H  N N 36  
A1D8P H9   H  N N 37  
A1D8P H10  H  N N 38  
A1D8P H11  H  N N 39  
A1D8P H12  H  N N 40  
A1D8P H13  H  N N 41  
A1D8P H14  H  N N 42  
A1D8P H15  H  N N 43  
A1D8P H16  H  N N 44  
A1D8P H17  H  N N 45  
A1D8P H18  H  N N 46  
ALA   N    N  N N 47  
ALA   CA   C  N S 48  
ALA   C    C  N N 49  
ALA   O    O  N N 50  
ALA   CB   C  N N 51  
ALA   OXT  O  N N 52  
ALA   H    H  N N 53  
ALA   H2   H  N N 54  
ALA   HA   H  N N 55  
ALA   HB1  H  N N 56  
ALA   HB2  H  N N 57  
ALA   HB3  H  N N 58  
ALA   HXT  H  N N 59  
ARG   N    N  N N 60  
ARG   CA   C  N S 61  
ARG   C    C  N N 62  
ARG   O    O  N N 63  
ARG   CB   C  N N 64  
ARG   CG   C  N N 65  
ARG   CD   C  N N 66  
ARG   NE   N  N N 67  
ARG   CZ   C  N N 68  
ARG   NH1  N  N N 69  
ARG   NH2  N  N N 70  
ARG   OXT  O  N N 71  
ARG   H    H  N N 72  
ARG   H2   H  N N 73  
ARG   HA   H  N N 74  
ARG   HB2  H  N N 75  
ARG   HB3  H  N N 76  
ARG   HG2  H  N N 77  
ARG   HG3  H  N N 78  
ARG   HD2  H  N N 79  
ARG   HD3  H  N N 80  
ARG   HE   H  N N 81  
ARG   HH11 H  N N 82  
ARG   HH12 H  N N 83  
ARG   HH21 H  N N 84  
ARG   HH22 H  N N 85  
ARG   HXT  H  N N 86  
ASN   N    N  N N 87  
ASN   CA   C  N S 88  
ASN   C    C  N N 89  
ASN   O    O  N N 90  
ASN   CB   C  N N 91  
ASN   CG   C  N N 92  
ASN   OD1  O  N N 93  
ASN   ND2  N  N N 94  
ASN   OXT  O  N N 95  
ASN   H    H  N N 96  
ASN   H2   H  N N 97  
ASN   HA   H  N N 98  
ASN   HB2  H  N N 99  
ASN   HB3  H  N N 100 
ASN   HD21 H  N N 101 
ASN   HD22 H  N N 102 
ASN   HXT  H  N N 103 
ASP   N    N  N N 104 
ASP   CA   C  N S 105 
ASP   C    C  N N 106 
ASP   O    O  N N 107 
ASP   CB   C  N N 108 
ASP   CG   C  N N 109 
ASP   OD1  O  N N 110 
ASP   OD2  O  N N 111 
ASP   OXT  O  N N 112 
ASP   H    H  N N 113 
ASP   H2   H  N N 114 
ASP   HA   H  N N 115 
ASP   HB2  H  N N 116 
ASP   HB3  H  N N 117 
ASP   HD2  H  N N 118 
ASP   HXT  H  N N 119 
CYS   N    N  N N 120 
CYS   CA   C  N R 121 
CYS   C    C  N N 122 
CYS   O    O  N N 123 
CYS   CB   C  N N 124 
CYS   SG   S  N N 125 
CYS   OXT  O  N N 126 
CYS   H    H  N N 127 
CYS   H2   H  N N 128 
CYS   HA   H  N N 129 
CYS   HB2  H  N N 130 
CYS   HB3  H  N N 131 
CYS   HG   H  N N 132 
CYS   HXT  H  N N 133 
GLN   N    N  N N 134 
GLN   CA   C  N S 135 
GLN   C    C  N N 136 
GLN   O    O  N N 137 
GLN   CB   C  N N 138 
GLN   CG   C  N N 139 
GLN   CD   C  N N 140 
GLN   OE1  O  N N 141 
GLN   NE2  N  N N 142 
GLN   OXT  O  N N 143 
GLN   H    H  N N 144 
GLN   H2   H  N N 145 
GLN   HA   H  N N 146 
GLN   HB2  H  N N 147 
GLN   HB3  H  N N 148 
GLN   HG2  H  N N 149 
GLN   HG3  H  N N 150 
GLN   HE21 H  N N 151 
GLN   HE22 H  N N 152 
GLN   HXT  H  N N 153 
GLU   N    N  N N 154 
GLU   CA   C  N S 155 
GLU   C    C  N N 156 
GLU   O    O  N N 157 
GLU   CB   C  N N 158 
GLU   CG   C  N N 159 
GLU   CD   C  N N 160 
GLU   OE1  O  N N 161 
GLU   OE2  O  N N 162 
GLU   OXT  O  N N 163 
GLU   H    H  N N 164 
GLU   H2   H  N N 165 
GLU   HA   H  N N 166 
GLU   HB2  H  N N 167 
GLU   HB3  H  N N 168 
GLU   HG2  H  N N 169 
GLU   HG3  H  N N 170 
GLU   HE2  H  N N 171 
GLU   HXT  H  N N 172 
GLY   N    N  N N 173 
GLY   CA   C  N N 174 
GLY   C    C  N N 175 
GLY   O    O  N N 176 
GLY   OXT  O  N N 177 
GLY   H    H  N N 178 
GLY   H2   H  N N 179 
GLY   HA2  H  N N 180 
GLY   HA3  H  N N 181 
GLY   HXT  H  N N 182 
HIS   N    N  N N 183 
HIS   CA   C  N S 184 
HIS   C    C  N N 185 
HIS   O    O  N N 186 
HIS   CB   C  N N 187 
HIS   CG   C  Y N 188 
HIS   ND1  N  Y N 189 
HIS   CD2  C  Y N 190 
HIS   CE1  C  Y N 191 
HIS   NE2  N  Y N 192 
HIS   OXT  O  N N 193 
HIS   H    H  N N 194 
HIS   H2   H  N N 195 
HIS   HA   H  N N 196 
HIS   HB2  H  N N 197 
HIS   HB3  H  N N 198 
HIS   HD1  H  N N 199 
HIS   HD2  H  N N 200 
HIS   HE1  H  N N 201 
HIS   HE2  H  N N 202 
HIS   HXT  H  N N 203 
HOH   O    O  N N 204 
HOH   H1   H  N N 205 
HOH   H2   H  N N 206 
ILE   N    N  N N 207 
ILE   CA   C  N S 208 
ILE   C    C  N N 209 
ILE   O    O  N N 210 
ILE   CB   C  N S 211 
ILE   CG1  C  N N 212 
ILE   CG2  C  N N 213 
ILE   CD1  C  N N 214 
ILE   OXT  O  N N 215 
ILE   H    H  N N 216 
ILE   H2   H  N N 217 
ILE   HA   H  N N 218 
ILE   HB   H  N N 219 
ILE   HG12 H  N N 220 
ILE   HG13 H  N N 221 
ILE   HG21 H  N N 222 
ILE   HG22 H  N N 223 
ILE   HG23 H  N N 224 
ILE   HD11 H  N N 225 
ILE   HD12 H  N N 226 
ILE   HD13 H  N N 227 
ILE   HXT  H  N N 228 
LEU   N    N  N N 229 
LEU   CA   C  N S 230 
LEU   C    C  N N 231 
LEU   O    O  N N 232 
LEU   CB   C  N N 233 
LEU   CG   C  N N 234 
LEU   CD1  C  N N 235 
LEU   CD2  C  N N 236 
LEU   OXT  O  N N 237 
LEU   H    H  N N 238 
LEU   H2   H  N N 239 
LEU   HA   H  N N 240 
LEU   HB2  H  N N 241 
LEU   HB3  H  N N 242 
LEU   HG   H  N N 243 
LEU   HD11 H  N N 244 
LEU   HD12 H  N N 245 
LEU   HD13 H  N N 246 
LEU   HD21 H  N N 247 
LEU   HD22 H  N N 248 
LEU   HD23 H  N N 249 
LEU   HXT  H  N N 250 
LYS   N    N  N N 251 
LYS   CA   C  N S 252 
LYS   C    C  N N 253 
LYS   O    O  N N 254 
LYS   CB   C  N N 255 
LYS   CG   C  N N 256 
LYS   CD   C  N N 257 
LYS   CE   C  N N 258 
LYS   NZ   N  N N 259 
LYS   OXT  O  N N 260 
LYS   H    H  N N 261 
LYS   H2   H  N N 262 
LYS   HA   H  N N 263 
LYS   HB2  H  N N 264 
LYS   HB3  H  N N 265 
LYS   HG2  H  N N 266 
LYS   HG3  H  N N 267 
LYS   HD2  H  N N 268 
LYS   HD3  H  N N 269 
LYS   HE2  H  N N 270 
LYS   HE3  H  N N 271 
LYS   HZ1  H  N N 272 
LYS   HZ2  H  N N 273 
LYS   HZ3  H  N N 274 
LYS   HXT  H  N N 275 
MET   N    N  N N 276 
MET   CA   C  N S 277 
MET   C    C  N N 278 
MET   O    O  N N 279 
MET   CB   C  N N 280 
MET   CG   C  N N 281 
MET   SD   S  N N 282 
MET   CE   C  N N 283 
MET   OXT  O  N N 284 
MET   H    H  N N 285 
MET   H2   H  N N 286 
MET   HA   H  N N 287 
MET   HB2  H  N N 288 
MET   HB3  H  N N 289 
MET   HG2  H  N N 290 
MET   HG3  H  N N 291 
MET   HE1  H  N N 292 
MET   HE2  H  N N 293 
MET   HE3  H  N N 294 
MET   HXT  H  N N 295 
MG    MG   MG N N 296 
PHE   N    N  N N 297 
PHE   CA   C  N S 298 
PHE   C    C  N N 299 
PHE   O    O  N N 300 
PHE   CB   C  N N 301 
PHE   CG   C  Y N 302 
PHE   CD1  C  Y N 303 
PHE   CD2  C  Y N 304 
PHE   CE1  C  Y N 305 
PHE   CE2  C  Y N 306 
PHE   CZ   C  Y N 307 
PHE   OXT  O  N N 308 
PHE   H    H  N N 309 
PHE   H2   H  N N 310 
PHE   HA   H  N N 311 
PHE   HB2  H  N N 312 
PHE   HB3  H  N N 313 
PHE   HD1  H  N N 314 
PHE   HD2  H  N N 315 
PHE   HE1  H  N N 316 
PHE   HE2  H  N N 317 
PHE   HZ   H  N N 318 
PHE   HXT  H  N N 319 
PRO   N    N  N N 320 
PRO   CA   C  N S 321 
PRO   C    C  N N 322 
PRO   O    O  N N 323 
PRO   CB   C  N N 324 
PRO   CG   C  N N 325 
PRO   CD   C  N N 326 
PRO   OXT  O  N N 327 
PRO   H    H  N N 328 
PRO   HA   H  N N 329 
PRO   HB2  H  N N 330 
PRO   HB3  H  N N 331 
PRO   HG2  H  N N 332 
PRO   HG3  H  N N 333 
PRO   HD2  H  N N 334 
PRO   HD3  H  N N 335 
PRO   HXT  H  N N 336 
SER   N    N  N N 337 
SER   CA   C  N S 338 
SER   C    C  N N 339 
SER   O    O  N N 340 
SER   CB   C  N N 341 
SER   OG   O  N N 342 
SER   OXT  O  N N 343 
SER   H    H  N N 344 
SER   H2   H  N N 345 
SER   HA   H  N N 346 
SER   HB2  H  N N 347 
SER   HB3  H  N N 348 
SER   HG   H  N N 349 
SER   HXT  H  N N 350 
THR   N    N  N N 351 
THR   CA   C  N S 352 
THR   C    C  N N 353 
THR   O    O  N N 354 
THR   CB   C  N R 355 
THR   OG1  O  N N 356 
THR   CG2  C  N N 357 
THR   OXT  O  N N 358 
THR   H    H  N N 359 
THR   H2   H  N N 360 
THR   HA   H  N N 361 
THR   HB   H  N N 362 
THR   HG1  H  N N 363 
THR   HG21 H  N N 364 
THR   HG22 H  N N 365 
THR   HG23 H  N N 366 
THR   HXT  H  N N 367 
TRP   N    N  N N 368 
TRP   CA   C  N S 369 
TRP   C    C  N N 370 
TRP   O    O  N N 371 
TRP   CB   C  N N 372 
TRP   CG   C  Y N 373 
TRP   CD1  C  Y N 374 
TRP   CD2  C  Y N 375 
TRP   NE1  N  Y N 376 
TRP   CE2  C  Y N 377 
TRP   CE3  C  Y N 378 
TRP   CZ2  C  Y N 379 
TRP   CZ3  C  Y N 380 
TRP   CH2  C  Y N 381 
TRP   OXT  O  N N 382 
TRP   H    H  N N 383 
TRP   H2   H  N N 384 
TRP   HA   H  N N 385 
TRP   HB2  H  N N 386 
TRP   HB3  H  N N 387 
TRP   HD1  H  N N 388 
TRP   HE1  H  N N 389 
TRP   HE3  H  N N 390 
TRP   HZ2  H  N N 391 
TRP   HZ3  H  N N 392 
TRP   HH2  H  N N 393 
TRP   HXT  H  N N 394 
TYR   N    N  N N 395 
TYR   CA   C  N S 396 
TYR   C    C  N N 397 
TYR   O    O  N N 398 
TYR   CB   C  N N 399 
TYR   CG   C  Y N 400 
TYR   CD1  C  Y N 401 
TYR   CD2  C  Y N 402 
TYR   CE1  C  Y N 403 
TYR   CE2  C  Y N 404 
TYR   CZ   C  Y N 405 
TYR   OH   O  N N 406 
TYR   OXT  O  N N 407 
TYR   H    H  N N 408 
TYR   H2   H  N N 409 
TYR   HA   H  N N 410 
TYR   HB2  H  N N 411 
TYR   HB3  H  N N 412 
TYR   HD1  H  N N 413 
TYR   HD2  H  N N 414 
TYR   HE1  H  N N 415 
TYR   HE2  H  N N 416 
TYR   HH   H  N N 417 
TYR   HXT  H  N N 418 
VAL   N    N  N N 419 
VAL   CA   C  N S 420 
VAL   C    C  N N 421 
VAL   O    O  N N 422 
VAL   CB   C  N N 423 
VAL   CG1  C  N N 424 
VAL   CG2  C  N N 425 
VAL   OXT  O  N N 426 
VAL   H    H  N N 427 
VAL   H2   H  N N 428 
VAL   HA   H  N N 429 
VAL   HB   H  N N 430 
VAL   HG11 H  N N 431 
VAL   HG12 H  N N 432 
VAL   HG13 H  N N 433 
VAL   HG21 H  N N 434 
VAL   HG22 H  N N 435 
VAL   HG23 H  N N 436 
VAL   HXT  H  N N 437 
ZN    ZN   ZN N N 438 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1D8P O27 C26  sing N N 1   
A1D8P C26 C28  doub Y N 2   
A1D8P C26 C25  sing Y N 3   
A1D8P C28 C4   sing Y N 4   
A1D8P C25 C24  doub Y N 5   
A1D8P C4  O3   sing N N 6   
A1D8P C4  C5   doub Y N 7   
A1D8P O3  C2   sing N N 8   
A1D8P C24 C5   sing Y N 9   
A1D8P C5  C6   sing N N 10  
A1D8P C2  C6   sing N N 11  
A1D8P C2  O1   doub N N 12  
A1D8P C6  C7   doub N Z 13  
A1D8P C7  C8   sing N N 14  
A1D8P C8  C23  doub Y N 15  
A1D8P C8  C9   sing Y N 16  
A1D8P C19 C20  sing N N 17  
A1D8P C19 C18  sing N N 18  
A1D8P C23 C16  sing Y N 19  
A1D8P C20 C21  sing N N 20  
A1D8P C9  C10  doub Y N 21  
A1D8P C18 O17  sing N N 22  
A1D8P C18 C22  sing N N 23  
A1D8P C16 O17  sing N N 24  
A1D8P C16 C11  doub Y N 25  
A1D8P C21 C22  sing N N 26  
A1D8P C10 C11  sing Y N 27  
A1D8P C11 O12  sing N N 28  
A1D8P O12 C13  sing N N 29  
A1D8P F14 C13  sing N N 30  
A1D8P C13 F15  sing N N 31  
A1D8P C7  H1   sing N N 32  
A1D8P C9  H2   sing N N 33  
A1D8P C10 H3   sing N N 34  
A1D8P C13 H4   sing N N 35  
A1D8P C18 H5   sing N N 36  
A1D8P C19 H6   sing N N 37  
A1D8P C19 H7   sing N N 38  
A1D8P C20 H8   sing N N 39  
A1D8P C20 H9   sing N N 40  
A1D8P C21 H10  sing N N 41  
A1D8P C21 H11  sing N N 42  
A1D8P C22 H12  sing N N 43  
A1D8P C22 H13  sing N N 44  
A1D8P C23 H14  sing N N 45  
A1D8P C24 H15  sing N N 46  
A1D8P C25 H16  sing N N 47  
A1D8P O27 H17  sing N N 48  
A1D8P C28 H18  sing N N 49  
ALA   N   CA   sing N N 50  
ALA   N   H    sing N N 51  
ALA   N   H2   sing N N 52  
ALA   CA  C    sing N N 53  
ALA   CA  CB   sing N N 54  
ALA   CA  HA   sing N N 55  
ALA   C   O    doub N N 56  
ALA   C   OXT  sing N N 57  
ALA   CB  HB1  sing N N 58  
ALA   CB  HB2  sing N N 59  
ALA   CB  HB3  sing N N 60  
ALA   OXT HXT  sing N N 61  
ARG   N   CA   sing N N 62  
ARG   N   H    sing N N 63  
ARG   N   H2   sing N N 64  
ARG   CA  C    sing N N 65  
ARG   CA  CB   sing N N 66  
ARG   CA  HA   sing N N 67  
ARG   C   O    doub N N 68  
ARG   C   OXT  sing N N 69  
ARG   CB  CG   sing N N 70  
ARG   CB  HB2  sing N N 71  
ARG   CB  HB3  sing N N 72  
ARG   CG  CD   sing N N 73  
ARG   CG  HG2  sing N N 74  
ARG   CG  HG3  sing N N 75  
ARG   CD  NE   sing N N 76  
ARG   CD  HD2  sing N N 77  
ARG   CD  HD3  sing N N 78  
ARG   NE  CZ   sing N N 79  
ARG   NE  HE   sing N N 80  
ARG   CZ  NH1  sing N N 81  
ARG   CZ  NH2  doub N N 82  
ARG   NH1 HH11 sing N N 83  
ARG   NH1 HH12 sing N N 84  
ARG   NH2 HH21 sing N N 85  
ARG   NH2 HH22 sing N N 86  
ARG   OXT HXT  sing N N 87  
ASN   N   CA   sing N N 88  
ASN   N   H    sing N N 89  
ASN   N   H2   sing N N 90  
ASN   CA  C    sing N N 91  
ASN   CA  CB   sing N N 92  
ASN   CA  HA   sing N N 93  
ASN   C   O    doub N N 94  
ASN   C   OXT  sing N N 95  
ASN   CB  CG   sing N N 96  
ASN   CB  HB2  sing N N 97  
ASN   CB  HB3  sing N N 98  
ASN   CG  OD1  doub N N 99  
ASN   CG  ND2  sing N N 100 
ASN   ND2 HD21 sing N N 101 
ASN   ND2 HD22 sing N N 102 
ASN   OXT HXT  sing N N 103 
ASP   N   CA   sing N N 104 
ASP   N   H    sing N N 105 
ASP   N   H2   sing N N 106 
ASP   CA  C    sing N N 107 
ASP   CA  CB   sing N N 108 
ASP   CA  HA   sing N N 109 
ASP   C   O    doub N N 110 
ASP   C   OXT  sing N N 111 
ASP   CB  CG   sing N N 112 
ASP   CB  HB2  sing N N 113 
ASP   CB  HB3  sing N N 114 
ASP   CG  OD1  doub N N 115 
ASP   CG  OD2  sing N N 116 
ASP   OD2 HD2  sing N N 117 
ASP   OXT HXT  sing N N 118 
CYS   N   CA   sing N N 119 
CYS   N   H    sing N N 120 
CYS   N   H2   sing N N 121 
CYS   CA  C    sing N N 122 
CYS   CA  CB   sing N N 123 
CYS   CA  HA   sing N N 124 
CYS   C   O    doub N N 125 
CYS   C   OXT  sing N N 126 
CYS   CB  SG   sing N N 127 
CYS   CB  HB2  sing N N 128 
CYS   CB  HB3  sing N N 129 
CYS   SG  HG   sing N N 130 
CYS   OXT HXT  sing N N 131 
GLN   N   CA   sing N N 132 
GLN   N   H    sing N N 133 
GLN   N   H2   sing N N 134 
GLN   CA  C    sing N N 135 
GLN   CA  CB   sing N N 136 
GLN   CA  HA   sing N N 137 
GLN   C   O    doub N N 138 
GLN   C   OXT  sing N N 139 
GLN   CB  CG   sing N N 140 
GLN   CB  HB2  sing N N 141 
GLN   CB  HB3  sing N N 142 
GLN   CG  CD   sing N N 143 
GLN   CG  HG2  sing N N 144 
GLN   CG  HG3  sing N N 145 
GLN   CD  OE1  doub N N 146 
GLN   CD  NE2  sing N N 147 
GLN   NE2 HE21 sing N N 148 
GLN   NE2 HE22 sing N N 149 
GLN   OXT HXT  sing N N 150 
GLU   N   CA   sing N N 151 
GLU   N   H    sing N N 152 
GLU   N   H2   sing N N 153 
GLU   CA  C    sing N N 154 
GLU   CA  CB   sing N N 155 
GLU   CA  HA   sing N N 156 
GLU   C   O    doub N N 157 
GLU   C   OXT  sing N N 158 
GLU   CB  CG   sing N N 159 
GLU   CB  HB2  sing N N 160 
GLU   CB  HB3  sing N N 161 
GLU   CG  CD   sing N N 162 
GLU   CG  HG2  sing N N 163 
GLU   CG  HG3  sing N N 164 
GLU   CD  OE1  doub N N 165 
GLU   CD  OE2  sing N N 166 
GLU   OE2 HE2  sing N N 167 
GLU   OXT HXT  sing N N 168 
GLY   N   CA   sing N N 169 
GLY   N   H    sing N N 170 
GLY   N   H2   sing N N 171 
GLY   CA  C    sing N N 172 
GLY   CA  HA2  sing N N 173 
GLY   CA  HA3  sing N N 174 
GLY   C   O    doub N N 175 
GLY   C   OXT  sing N N 176 
GLY   OXT HXT  sing N N 177 
HIS   N   CA   sing N N 178 
HIS   N   H    sing N N 179 
HIS   N   H2   sing N N 180 
HIS   CA  C    sing N N 181 
HIS   CA  CB   sing N N 182 
HIS   CA  HA   sing N N 183 
HIS   C   O    doub N N 184 
HIS   C   OXT  sing N N 185 
HIS   CB  CG   sing N N 186 
HIS   CB  HB2  sing N N 187 
HIS   CB  HB3  sing N N 188 
HIS   CG  ND1  sing Y N 189 
HIS   CG  CD2  doub Y N 190 
HIS   ND1 CE1  doub Y N 191 
HIS   ND1 HD1  sing N N 192 
HIS   CD2 NE2  sing Y N 193 
HIS   CD2 HD2  sing N N 194 
HIS   CE1 NE2  sing Y N 195 
HIS   CE1 HE1  sing N N 196 
HIS   NE2 HE2  sing N N 197 
HIS   OXT HXT  sing N N 198 
HOH   O   H1   sing N N 199 
HOH   O   H2   sing N N 200 
ILE   N   CA   sing N N 201 
ILE   N   H    sing N N 202 
ILE   N   H2   sing N N 203 
ILE   CA  C    sing N N 204 
ILE   CA  CB   sing N N 205 
ILE   CA  HA   sing N N 206 
ILE   C   O    doub N N 207 
ILE   C   OXT  sing N N 208 
ILE   CB  CG1  sing N N 209 
ILE   CB  CG2  sing N N 210 
ILE   CB  HB   sing N N 211 
ILE   CG1 CD1  sing N N 212 
ILE   CG1 HG12 sing N N 213 
ILE   CG1 HG13 sing N N 214 
ILE   CG2 HG21 sing N N 215 
ILE   CG2 HG22 sing N N 216 
ILE   CG2 HG23 sing N N 217 
ILE   CD1 HD11 sing N N 218 
ILE   CD1 HD12 sing N N 219 
ILE   CD1 HD13 sing N N 220 
ILE   OXT HXT  sing N N 221 
LEU   N   CA   sing N N 222 
LEU   N   H    sing N N 223 
LEU   N   H2   sing N N 224 
LEU   CA  C    sing N N 225 
LEU   CA  CB   sing N N 226 
LEU   CA  HA   sing N N 227 
LEU   C   O    doub N N 228 
LEU   C   OXT  sing N N 229 
LEU   CB  CG   sing N N 230 
LEU   CB  HB2  sing N N 231 
LEU   CB  HB3  sing N N 232 
LEU   CG  CD1  sing N N 233 
LEU   CG  CD2  sing N N 234 
LEU   CG  HG   sing N N 235 
LEU   CD1 HD11 sing N N 236 
LEU   CD1 HD12 sing N N 237 
LEU   CD1 HD13 sing N N 238 
LEU   CD2 HD21 sing N N 239 
LEU   CD2 HD22 sing N N 240 
LEU   CD2 HD23 sing N N 241 
LEU   OXT HXT  sing N N 242 
LYS   N   CA   sing N N 243 
LYS   N   H    sing N N 244 
LYS   N   H2   sing N N 245 
LYS   CA  C    sing N N 246 
LYS   CA  CB   sing N N 247 
LYS   CA  HA   sing N N 248 
LYS   C   O    doub N N 249 
LYS   C   OXT  sing N N 250 
LYS   CB  CG   sing N N 251 
LYS   CB  HB2  sing N N 252 
LYS   CB  HB3  sing N N 253 
LYS   CG  CD   sing N N 254 
LYS   CG  HG2  sing N N 255 
LYS   CG  HG3  sing N N 256 
LYS   CD  CE   sing N N 257 
LYS   CD  HD2  sing N N 258 
LYS   CD  HD3  sing N N 259 
LYS   CE  NZ   sing N N 260 
LYS   CE  HE2  sing N N 261 
LYS   CE  HE3  sing N N 262 
LYS   NZ  HZ1  sing N N 263 
LYS   NZ  HZ2  sing N N 264 
LYS   NZ  HZ3  sing N N 265 
LYS   OXT HXT  sing N N 266 
MET   N   CA   sing N N 267 
MET   N   H    sing N N 268 
MET   N   H2   sing N N 269 
MET   CA  C    sing N N 270 
MET   CA  CB   sing N N 271 
MET   CA  HA   sing N N 272 
MET   C   O    doub N N 273 
MET   C   OXT  sing N N 274 
MET   CB  CG   sing N N 275 
MET   CB  HB2  sing N N 276 
MET   CB  HB3  sing N N 277 
MET   CG  SD   sing N N 278 
MET   CG  HG2  sing N N 279 
MET   CG  HG3  sing N N 280 
MET   SD  CE   sing N N 281 
MET   CE  HE1  sing N N 282 
MET   CE  HE2  sing N N 283 
MET   CE  HE3  sing N N 284 
MET   OXT HXT  sing N N 285 
PHE   N   CA   sing N N 286 
PHE   N   H    sing N N 287 
PHE   N   H2   sing N N 288 
PHE   CA  C    sing N N 289 
PHE   CA  CB   sing N N 290 
PHE   CA  HA   sing N N 291 
PHE   C   O    doub N N 292 
PHE   C   OXT  sing N N 293 
PHE   CB  CG   sing N N 294 
PHE   CB  HB2  sing N N 295 
PHE   CB  HB3  sing N N 296 
PHE   CG  CD1  doub Y N 297 
PHE   CG  CD2  sing Y N 298 
PHE   CD1 CE1  sing Y N 299 
PHE   CD1 HD1  sing N N 300 
PHE   CD2 CE2  doub Y N 301 
PHE   CD2 HD2  sing N N 302 
PHE   CE1 CZ   doub Y N 303 
PHE   CE1 HE1  sing N N 304 
PHE   CE2 CZ   sing Y N 305 
PHE   CE2 HE2  sing N N 306 
PHE   CZ  HZ   sing N N 307 
PHE   OXT HXT  sing N N 308 
PRO   N   CA   sing N N 309 
PRO   N   CD   sing N N 310 
PRO   N   H    sing N N 311 
PRO   CA  C    sing N N 312 
PRO   CA  CB   sing N N 313 
PRO   CA  HA   sing N N 314 
PRO   C   O    doub N N 315 
PRO   C   OXT  sing N N 316 
PRO   CB  CG   sing N N 317 
PRO   CB  HB2  sing N N 318 
PRO   CB  HB3  sing N N 319 
PRO   CG  CD   sing N N 320 
PRO   CG  HG2  sing N N 321 
PRO   CG  HG3  sing N N 322 
PRO   CD  HD2  sing N N 323 
PRO   CD  HD3  sing N N 324 
PRO   OXT HXT  sing N N 325 
SER   N   CA   sing N N 326 
SER   N   H    sing N N 327 
SER   N   H2   sing N N 328 
SER   CA  C    sing N N 329 
SER   CA  CB   sing N N 330 
SER   CA  HA   sing N N 331 
SER   C   O    doub N N 332 
SER   C   OXT  sing N N 333 
SER   CB  OG   sing N N 334 
SER   CB  HB2  sing N N 335 
SER   CB  HB3  sing N N 336 
SER   OG  HG   sing N N 337 
SER   OXT HXT  sing N N 338 
THR   N   CA   sing N N 339 
THR   N   H    sing N N 340 
THR   N   H2   sing N N 341 
THR   CA  C    sing N N 342 
THR   CA  CB   sing N N 343 
THR   CA  HA   sing N N 344 
THR   C   O    doub N N 345 
THR   C   OXT  sing N N 346 
THR   CB  OG1  sing N N 347 
THR   CB  CG2  sing N N 348 
THR   CB  HB   sing N N 349 
THR   OG1 HG1  sing N N 350 
THR   CG2 HG21 sing N N 351 
THR   CG2 HG22 sing N N 352 
THR   CG2 HG23 sing N N 353 
THR   OXT HXT  sing N N 354 
TRP   N   CA   sing N N 355 
TRP   N   H    sing N N 356 
TRP   N   H2   sing N N 357 
TRP   CA  C    sing N N 358 
TRP   CA  CB   sing N N 359 
TRP   CA  HA   sing N N 360 
TRP   C   O    doub N N 361 
TRP   C   OXT  sing N N 362 
TRP   CB  CG   sing N N 363 
TRP   CB  HB2  sing N N 364 
TRP   CB  HB3  sing N N 365 
TRP   CG  CD1  doub Y N 366 
TRP   CG  CD2  sing Y N 367 
TRP   CD1 NE1  sing Y N 368 
TRP   CD1 HD1  sing N N 369 
TRP   CD2 CE2  doub Y N 370 
TRP   CD2 CE3  sing Y N 371 
TRP   NE1 CE2  sing Y N 372 
TRP   NE1 HE1  sing N N 373 
TRP   CE2 CZ2  sing Y N 374 
TRP   CE3 CZ3  doub Y N 375 
TRP   CE3 HE3  sing N N 376 
TRP   CZ2 CH2  doub Y N 377 
TRP   CZ2 HZ2  sing N N 378 
TRP   CZ3 CH2  sing Y N 379 
TRP   CZ3 HZ3  sing N N 380 
TRP   CH2 HH2  sing N N 381 
TRP   OXT HXT  sing N N 382 
TYR   N   CA   sing N N 383 
TYR   N   H    sing N N 384 
TYR   N   H2   sing N N 385 
TYR   CA  C    sing N N 386 
TYR   CA  CB   sing N N 387 
TYR   CA  HA   sing N N 388 
TYR   C   O    doub N N 389 
TYR   C   OXT  sing N N 390 
TYR   CB  CG   sing N N 391 
TYR   CB  HB2  sing N N 392 
TYR   CB  HB3  sing N N 393 
TYR   CG  CD1  doub Y N 394 
TYR   CG  CD2  sing Y N 395 
TYR   CD1 CE1  sing Y N 396 
TYR   CD1 HD1  sing N N 397 
TYR   CD2 CE2  doub Y N 398 
TYR   CD2 HD2  sing N N 399 
TYR   CE1 CZ   doub Y N 400 
TYR   CE1 HE1  sing N N 401 
TYR   CE2 CZ   sing Y N 402 
TYR   CE2 HE2  sing N N 403 
TYR   CZ  OH   sing N N 404 
TYR   OH  HH   sing N N 405 
TYR   OXT HXT  sing N N 406 
VAL   N   CA   sing N N 407 
VAL   N   H    sing N N 408 
VAL   N   H2   sing N N 409 
VAL   CA  C    sing N N 410 
VAL   CA  CB   sing N N 411 
VAL   CA  HA   sing N N 412 
VAL   C   O    doub N N 413 
VAL   C   OXT  sing N N 414 
VAL   CB  CG1  sing N N 415 
VAL   CB  CG2  sing N N 416 
VAL   CB  HB   sing N N 417 
VAL   CG1 HG11 sing N N 418 
VAL   CG1 HG12 sing N N 419 
VAL   CG1 HG13 sing N N 420 
VAL   CG2 HG21 sing N N 421 
VAL   CG2 HG22 sing N N 422 
VAL   CG2 HG23 sing N N 423 
VAL   OXT HXT  sing N N 424 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           22277019 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5WQA 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8ZQU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017101 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012404 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006106 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F  ? ? 4.90428  4.07044 12.99538 1.63651  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
MG ? ? 9.41153  2.53737 2.59044  63.03566 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 2.14387  29.76375 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLU   A 1 87  ? -9.73416  22.74472  -3.52988  1.000 47.05138 ? 87  GLU   A N   1 
ATOM   2    C  CA  . GLU   A 1 87  ? -10.26596 23.18960  -4.81351  1.000 50.03442 ? 87  GLU   A CA  1 
ATOM   3    C  C   . GLU   A 1 87  ? -10.67760 21.98281  -5.66000  1.000 47.22388 ? 87  GLU   A C   1 
ATOM   4    O  O   . GLU   A 1 87  ? -10.04532 20.92529  -5.57776  1.000 45.43182 ? 87  GLU   A O   1 
ATOM   5    C  CB  . GLU   A 1 87  ? -9.23240  24.03409  -5.55846  1.000 43.18865 ? 87  GLU   A CB  1 
ATOM   6    C  CG  . GLU   A 1 87  ? -9.81265  25.15909  -6.39018  1.000 48.95060 ? 87  GLU   A CG  1 
ATOM   7    C  CD  . GLU   A 1 87  ? -8.72882  25.97067  -7.07474  1.000 56.93665 ? 87  GLU   A CD  1 
ATOM   8    O  OE1 . GLU   A 1 87  ? -7.61723  26.08497  -6.51032  1.000 57.32770 ? 87  GLU   A OE1 1 
ATOM   9    O  OE2 . GLU   A 1 87  ? -8.98335  26.49062  -8.17873  1.000 60.88397 ? 87  GLU   A OE2 1 
ATOM   10   N  N   . GLN   A 1 88  ? -11.73730 22.13179  -6.46057  1.000 46.54292 ? 88  GLN   A N   1 
ATOM   11   C  CA  . GLN   A 1 88  ? -12.10197 21.05524  -7.37364  1.000 47.20885 ? 88  GLN   A CA  1 
ATOM   12   C  C   . GLN   A 1 88  ? -10.96439 20.73508  -8.32902  1.000 42.80970 ? 88  GLN   A C   1 
ATOM   13   O  O   . GLN   A 1 88  ? -10.81805 19.58148  -8.75349  1.000 35.56888 ? 88  GLN   A O   1 
ATOM   14   C  CB  . GLN   A 1 88  ? -13.35278 21.41087  -8.18377  1.000 51.87880 ? 88  GLN   A CB  1 
ATOM   15   C  CG  . GLN   A 1 88  ? -14.54030 21.86904  -7.37611  1.000 51.52551 ? 88  GLN   A CG  1 
ATOM   16   C  CD  . GLN   A 1 88  ? -15.72675 22.18185  -8.26287  1.000 58.65421 ? 88  GLN   A CD  1 
ATOM   17   O  OE1 . GLN   A 1 88  ? -16.55023 23.04292  -7.93988  1.000 63.36346 ? 88  GLN   A OE1 1 
ATOM   18   N  NE2 . GLN   A 1 88  ? -15.81833 21.47457  -9.39711  1.000 61.50872 ? 88  GLN   A NE2 1 
ATOM   19   N  N   . GLU   A 1 89  ? -10.15246 21.74373  -8.67294  1.000 43.04868 ? 89  GLU   A N   1 
ATOM   20   C  CA  . GLU   A 1 89  ? -9.05599  21.55077  -9.61540  1.000 37.94723 ? 89  GLU   A CA  1 
ATOM   21   C  C   . GLU   A 1 89  ? -7.96024  20.66846  -9.03245  1.000 36.21826 ? 89  GLU   A C   1 
ATOM   22   O  O   . GLU   A 1 89  ? -7.36257  19.86051  -9.75622  1.000 31.00170 ? 89  GLU   A O   1 
ATOM   23   C  CB  . GLU   A 1 89  ? -8.47750  22.90006  -10.02532 1.000 45.55389 ? 89  GLU   A CB  1 
ATOM   24   C  CG  . GLU   A 1 89  ? -9.45496  23.79957  -10.73564 1.000 51.00090 ? 89  GLU   A CG  1 
ATOM   25   C  CD  . GLU   A 1 89  ? -8.91183  25.20162  -10.92867 1.000 59.05860 ? 89  GLU   A CD  1 
ATOM   26   O  OE1 . GLU   A 1 89  ? -7.67705  25.35269  -11.07609 1.000 65.16114 ? 89  GLU   A OE1 1 
ATOM   27   O  OE2 . GLU   A 1 89  ? -9.72260  26.15247  -10.92761 1.000 60.36597 ? 89  GLU   A OE2 1 
ATOM   28   N  N   . ASP   A 1 90  ? -7.65626  20.83501  -7.73802  1.000 37.72905 ? 90  ASP   A N   1 
ATOM   29   C  CA  . ASP   A 1 90  ? -6.69170  19.95898  -7.07490  1.000 35.67815 ? 90  ASP   A CA  1 
ATOM   30   C  C   . ASP   A 1 90  ? -7.15425  18.51102  -7.13131  1.000 27.27872 ? 90  ASP   A C   1 
ATOM   31   O  O   . ASP   A 1 90  ? -6.36787  17.60699  -7.43825  1.000 24.96275 ? 90  ASP   A O   1 
ATOM   32   C  CB  . ASP   A 1 90  ? -6.48697  20.38600  -5.61627  1.000 35.74961 ? 90  ASP   A CB  1 
ATOM   33   C  CG  . ASP   A 1 90  ? -5.75323  21.70984  -5.48410  1.000 49.87652 ? 90  ASP   A CG  1 
ATOM   34   O  OD1 . ASP   A 1 90  ? -6.40989  22.76950  -5.57746  1.000 53.08168 ? 90  ASP   A OD1 1 
ATOM   35   O  OD2 . ASP   A 1 90  ? -4.51818  21.69218  -5.27761  1.000 55.74613 ? 90  ASP   A OD2 1 
ATOM   36   N  N   . VAL   A 1 91  ? -8.43753  18.27879  -6.83296  1.000 28.44642 ? 91  VAL   A N   1 
ATOM   37   C  CA  . VAL   A 1 91  ? -8.98655  16.92630  -6.84458  1.000 26.63357 ? 91  VAL   A CA  1 
ATOM   38   C  C   . VAL   A 1 91  ? -9.04732  16.38374  -8.26705  1.000 24.62618 ? 91  VAL   A C   1 
ATOM   39   O  O   . VAL   A 1 91  ? -8.75577  15.20411  -8.50675  1.000 20.71753 ? 91  VAL   A O   1 
ATOM   40   C  CB  . VAL   A 1 91  ? -10.37055 16.90821  -6.17177  1.000 27.72732 ? 91  VAL   A CB  1 
ATOM   41   C  CG1 . VAL   A 1 91  ? -10.95904 15.50887  -6.21383  1.000 23.51852 ? 91  VAL   A CG1 1 
ATOM   42   C  CG2 . VAL   A 1 91  ? -10.26497 17.40875  -4.73533  1.000 31.51047 ? 91  VAL   A CG2 1 
ATOM   43   N  N   . LEU   A 1 92  ? -9.43357  17.22812  -9.23064  1.000 21.81268 ? 92  LEU   A N   1 
ATOM   44   C  CA  . LEU   A 1 92  ? -9.45231  16.79395  -10.62436 1.000 21.12614 ? 92  LEU   A CA  1 
ATOM   45   C  C   . LEU   A 1 92  ? -8.05818  16.36301  -11.06959 1.000 23.64779 ? 92  LEU   A C   1 
ATOM   46   O  O   . LEU   A 1 92  ? -7.88469  15.27947  -11.63863 1.000 20.28462 ? 92  LEU   A O   1 
ATOM   47   C  CB  . LEU   A 1 92  ? -10.00205 17.90426  -11.52714 1.000 19.58575 ? 92  LEU   A CB  1 
ATOM   48   C  CG  . LEU   A 1 92  ? -9.91331  17.65742  -13.04136 1.000 16.69360 ? 92  LEU   A CG  1 
ATOM   49   C  CD1 . LEU   A 1 92  ? -10.74215 16.45787  -13.45370 1.000 18.08137 ? 92  LEU   A CD1 1 
ATOM   50   C  CD2 . LEU   A 1 92  ? -10.34183 18.90124  -13.82338 1.000 18.68552 ? 92  LEU   A CD2 1 
ATOM   51   N  N   . ALA   A 1 93  ? -7.04208  17.18265  -10.78084 1.000 20.01937 ? 93  ALA   A N   1 
ATOM   52   C  CA  . ALA   A 1 93  ? -5.68424  16.83583  -11.18951 1.000 21.20693 ? 93  ALA   A CA  1 
ATOM   53   C  C   . ALA   A 1 93  ? -5.21670  15.55055  -10.51805 1.000 20.89871 ? 93  ALA   A C   1 
ATOM   54   O  O   . ALA   A 1 93  ? -4.50441  14.74352  -11.12829 1.000 23.15010 ? 93  ALA   A O   1 
ATOM   55   C  CB  . ALA   A 1 93  ? -4.72567  17.98804  -10.87735 1.000 19.78252 ? 93  ALA   A CB  1 
ATOM   56   N  N   . LYS   A 1 94  ? -5.58679  15.35451  -9.25174  1.000 22.59517 ? 94  LYS   A N   1 
ATOM   57   C  CA  . LYS   A 1 94  ? -5.30277  14.08939  -8.58382  1.000 24.76327 ? 94  LYS   A CA  1 
ATOM   58   C  C   . LYS   A 1 94  ? -5.89821  12.91431  -9.35799  1.000 23.14387 ? 94  LYS   A C   1 
ATOM   59   O  O   . LYS   A 1 94  ? -5.21466  11.92155  -9.63007  1.000 23.17030 ? 94  LYS   A O   1 
ATOM   60   C  CB  . LYS   A 1 94  ? -5.84781  14.13181  -7.15532  1.000 21.48541 ? 94  LYS   A CB  1 
ATOM   61   C  CG  . LYS   A 1 94  ? -5.31640  13.04083  -6.24589  1.000 28.45574 ? 94  LYS   A CG  1 
ATOM   62   C  CD  . LYS   A 1 94  ? -6.01564  13.11093  -4.88587  1.000 30.94376 ? 94  LYS   A CD  1 
ATOM   63   C  CE  . LYS   A 1 94  ? -7.51791  12.88638  -5.03279  1.000 31.17238 ? 94  LYS   A CE  1 
ATOM   64   N  NZ  . LYS   A 1 94  ? -8.27160  13.19456  -3.76695  1.000 34.32110 ? 94  LYS   A NZ  1 
ATOM   65   N  N   . GLU   A 1 95  ? -7.17680  13.01224  -9.72456  1.000 20.80152 ? 95  GLU   A N   1 
ATOM   66   C  CA  . GLU   A 1 95  ? -7.81501  11.91853  -10.45560 1.000 22.16866 ? 95  GLU   A CA  1 
ATOM   67   C  C   . GLU   A 1 95  ? -7.14348  11.67923  -11.79788 1.000 19.52273 ? 95  GLU   A C   1 
ATOM   68   O  O   . GLU   A 1 95  ? -7.01980  10.53334  -12.23028 1.000 21.86416 ? 95  GLU   A O   1 
ATOM   69   C  CB  . GLU   A 1 95  ? -9.30034  12.21119  -10.65896 1.000 17.47314 ? 95  GLU   A CB  1 
ATOM   70   C  CG  . GLU   A 1 95  ? -10.09349 12.26231  -9.37570  1.000 18.60279 ? 95  GLU   A CG  1 
ATOM   71   C  CD  . GLU   A 1 95  ? -10.15475 10.91453  -8.67335  1.000 24.31571 ? 95  GLU   A CD  1 
ATOM   72   O  OE1 . GLU   A 1 95  ? -9.91170  9.87244   -9.32103  1.000 23.08138 ? 95  GLU   A OE1 1 
ATOM   73   O  OE2 . GLU   A 1 95  ? -10.45154 10.90191  -7.46620  1.000 24.91034 ? 95  GLU   A OE2 1 
ATOM   74   N  N   . LEU   A 1 96  ? -6.68840  12.74093  -12.46113 1.000 19.24668 ? 96  LEU   A N   1 
ATOM   75   C  CA  . LEU   A 1 96  ? -6.06716  12.58998  -13.76679 1.000 21.36626 ? 96  LEU   A CA  1 
ATOM   76   C  C   . LEU   A 1 96  ? -4.69178  11.93307  -13.70015 1.000 24.04803 ? 96  LEU   A C   1 
ATOM   77   O  O   . LEU   A 1 96  ? -4.18690  11.50282  -14.74036 1.000 22.41739 ? 96  LEU   A O   1 
ATOM   78   C  CB  . LEU   A 1 96  ? -5.99060  13.95259  -14.45430 1.000 17.95326 ? 96  LEU   A CB  1 
ATOM   79   C  CG  . LEU   A 1 96  ? -7.35053  14.46938  -14.91467 1.000 15.57982 ? 96  LEU   A CG  1 
ATOM   80   C  CD1 . LEU   A 1 96  ? -7.26809  15.93313  -15.39226 1.000 18.33281 ? 96  LEU   A CD1 1 
ATOM   81   C  CD2 . LEU   A 1 96  ? -7.86316  13.57934  -16.03881 1.000 17.87609 ? 96  LEU   A CD2 1 
ATOM   82   N  N   . GLU   A 1 97  ? -4.09115  11.81181  -12.51180 1.000 21.98329 ? 97  GLU   A N   1 
ATOM   83   C  CA  . GLU   A 1 97  ? -2.88994  10.99537  -12.36711 1.000 26.57552 ? 97  GLU   A CA  1 
ATOM   84   C  C   . GLU   A 1 97  ? -3.14489  9.51186   -12.62439 1.000 25.24379 ? 97  GLU   A C   1 
ATOM   85   O  O   . GLU   A 1 97  ? -2.17593  8.75855   -12.76392 1.000 20.43155 ? 97  GLU   A O   1 
ATOM   86   C  CB  . GLU   A 1 97  ? -2.28720  11.16654  -10.96451 1.000 30.35058 ? 97  GLU   A CB  1 
ATOM   87   C  CG  . GLU   A 1 97  ? -1.83254  12.59162  -10.62064 1.000 26.35178 ? 97  GLU   A CG  1 
ATOM   88   C  CD  . GLU   A 1 97  ? -1.52628  12.76878  -9.13583  1.000 32.31190 ? 97  GLU   A CD  1 
ATOM   89   O  OE1 . GLU   A 1 97  ? -1.29406  11.75710  -8.44551  1.000 29.65486 ? 97  GLU   A OE1 1 
ATOM   90   O  OE2 . GLU   A 1 97  ? -1.54249  13.92079  -8.64953  1.000 38.82365 ? 97  GLU   A OE2 1 
ATOM   91   N  N   . ASP   A 1 98  ? -4.40930  9.07175   -12.67243 1.000 22.82468 ? 98  ASP   A N   1 
ATOM   92   C  CA  . ASP   A 1 98  ? -4.75611  7.68022   -12.94551 1.000 21.31489 ? 98  ASP   A CA  1 
ATOM   93   C  C   . ASP   A 1 98  ? -4.95786  7.38979   -14.42996 1.000 20.87283 ? 98  ASP   A C   1 
ATOM   94   O  O   . ASP   A 1 98  ? -5.41461  6.29314   -14.77805 1.000 19.10401 ? 98  ASP   A O   1 
ATOM   95   C  CB  . ASP   A 1 98  ? -6.03438  7.29132   -12.19864 1.000 22.28159 ? 98  ASP   A CB  1 
ATOM   96   C  CG  . ASP   A 1 98  ? -5.82039  7.14662   -10.71098 1.000 27.03721 ? 98  ASP   A CG  1 
ATOM   97   O  OD1 . ASP   A 1 98  ? -4.65147  6.99213   -10.28169 1.000 25.86752 ? 98  ASP   A OD1 1 
ATOM   98   O  OD2 . ASP   A 1 98  ? -6.83304  7.19251   -9.97762  1.000 26.85097 ? 98  ASP   A OD2 1 
ATOM   99   N  N   . VAL   A 1 99  ? -4.63395  8.34126   -15.30651 1.000 17.44525 ? 99  VAL   A N   1 
ATOM   100  C  CA  . VAL   A 1 99  ? -4.99374  8.22524   -16.71308 1.000 18.29609 ? 99  VAL   A CA  1 
ATOM   101  C  C   . VAL   A 1 99  ? -4.37433  7.00570   -17.39477 1.000 17.77927 ? 99  VAL   A C   1 
ATOM   102  O  O   . VAL   A 1 99  ? -4.90652  6.52829   -18.40100 1.000 14.96914 ? 99  VAL   A O   1 
ATOM   103  C  CB  . VAL   A 1 99  ? -4.61509  9.52886   -17.44204 1.000 19.79746 ? 99  VAL   A CB  1 
ATOM   104  C  CG1 . VAL   A 1 99  ? -3.10770  9.67393   -17.55674 1.000 18.63741 ? 99  VAL   A CG1 1 
ATOM   105  C  CG2 . VAL   A 1 99  ? -5.25373  9.56088   -18.78619 1.000 19.18686 ? 99  VAL   A CG2 1 
ATOM   106  N  N   . ASN   A 1 100 ? -3.27724  6.47024   -16.86886 1.000 14.84223 ? 100 ASN   A N   1 
ATOM   107  C  CA  . ASN   A 1 100 ? -2.66608  5.28421   -17.45924 1.000 16.57591 ? 100 ASN   A CA  1 
ATOM   108  C  C   . ASN   A 1 100 ? -3.21041  3.97919   -16.88006 1.000 14.34091 ? 100 ASN   A C   1 
ATOM   109  O  O   . ASN   A 1 100 ? -2.70694  2.90897   -17.22851 1.000 16.39226 ? 100 ASN   A O   1 
ATOM   110  C  CB  . ASN   A 1 100 ? -1.14252  5.30074   -17.26902 1.000 17.55254 ? 100 ASN   A CB  1 
ATOM   111  C  CG  . ASN   A 1 100 ? -0.46892  6.48650   -17.92417 1.000 20.84932 ? 100 ASN   A CG  1 
ATOM   112  O  OD1 . ASN   A 1 100 ? -1.03733  7.15420   -18.77902 1.000 22.56646 ? 100 ASN   A OD1 1 
ATOM   113  N  ND2 . ASN   A 1 100 ? 0.77200   6.75064   -17.52119 1.000 29.39834 ? 100 ASN   A ND2 1 
ATOM   114  N  N   . LYS   A 1 101 ? -4.20970  4.03050   -16.01053 1.000 16.28092 ? 101 LYS   A N   1 
ATOM   115  C  CA  . LYS   A 1 101 ? -4.69438  2.85031   -15.30163 1.000 15.68527 ? 101 LYS   A CA  1 
ATOM   116  C  C   . LYS   A 1 101 ? -6.07682  2.45129   -15.79694 1.000 17.04387 ? 101 LYS   A C   1 
ATOM   117  O  O   . LYS   A 1 101 ? -6.95434  3.30483   -15.97842 1.000 12.89862 ? 101 LYS   A O   1 
ATOM   118  C  CB  . LYS   A 1 101 ? -4.76990  3.10036   -13.79059 1.000 16.22579 ? 101 LYS   A CB  1 
ATOM   119  C  CG  . LYS   A 1 101 ? -3.44708  3.50973   -13.13143 1.000 20.58303 ? 101 LYS   A CG  1 
ATOM   120  C  CD  . LYS   A 1 101 ? -3.46450  3.07213   -11.68693 1.000 26.84853 ? 101 LYS   A CD  1 
ATOM   121  C  CE  . LYS   A 1 101 ? -2.85641  4.11165   -10.76362 1.000 38.88347 ? 101 LYS   A CE  1 
ATOM   122  N  NZ  . LYS   A 1 101 ? -1.40873  4.25748   -11.00753 1.000 30.36904 ? 101 LYS   A NZ  1 
ATOM   123  N  N   . TRP   A 1 102 ? -6.26668  1.14688   -15.97835 1.000 18.32550 ? 102 TRP   A N   1 
ATOM   124  C  CA  . TRP   A 1 102 ? -7.59185  0.58210   -16.21506 1.000 15.86096 ? 102 TRP   A CA  1 
ATOM   125  C  C   . TRP   A 1 102 ? -8.45852  0.81139   -14.98553 1.000 18.50132 ? 102 TRP   A C   1 
ATOM   126  O  O   . TRP   A 1 102 ? -8.01143  0.60066   -13.85723 1.000 21.89060 ? 102 TRP   A O   1 
ATOM   127  C  CB  . TRP   A 1 102 ? -7.45136  -0.91265  -16.49277 1.000 17.47285 ? 102 TRP   A CB  1 
ATOM   128  C  CG  . TRP   A 1 102 ? -8.51004  -1.56530  -17.34345 1.000 15.98465 ? 102 TRP   A CG  1 
ATOM   129  C  CD1 . TRP   A 1 102 ? -9.46576  -2.45987  -16.92623 1.000 11.49452 ? 102 TRP   A CD1 1 
ATOM   130  C  CD2 . TRP   A 1 102 ? -8.67422  -1.43049  -18.75778 1.000 9.56334  ? 102 TRP   A CD2 1 
ATOM   131  N  NE1 . TRP   A 1 102 ? -10.21692 -2.87889  -17.99950 1.000 11.77276 ? 102 TRP   A NE1 1 
ATOM   132  C  CE2 . TRP   A 1 102 ? -9.74491  -2.27117  -19.13694 1.000 13.06933 ? 102 TRP   A CE2 1 
ATOM   133  C  CE3 . TRP   A 1 102 ? -8.01549  -0.68199  -19.74618 1.000 13.26196 ? 102 TRP   A CE3 1 
ATOM   134  C  CZ2 . TRP   A 1 102 ? -10.19742 -2.35938  -20.46428 1.000 11.00797 ? 102 TRP   A CZ2 1 
ATOM   135  C  CZ3 . TRP   A 1 102 ? -8.45454  -0.78171  -21.06385 1.000 9.41709  ? 102 TRP   A CZ3 1 
ATOM   136  C  CH2 . TRP   A 1 102 ? -9.52942  -1.61741  -21.40879 1.000 10.42011 ? 102 TRP   A CH2 1 
ATOM   137  N  N   . GLY   A 1 103 ? -9.69182  1.25643   -15.18293 1.000 14.63739 ? 103 GLY   A N   1 
ATOM   138  C  CA  . GLY   A 1 103 ? -10.52274 1.57446   -14.02868 1.000 19.21334 ? 103 GLY   A CA  1 
ATOM   139  C  C   . GLY   A 1 103 ? -10.38541 2.98435   -13.48634 1.000 19.72233 ? 103 GLY   A C   1 
ATOM   140  O  O   . GLY   A 1 103 ? -10.75982 3.23628   -12.32893 1.000 18.94991 ? 103 GLY   A O   1 
ATOM   141  N  N   . LEU   A 1 104 ? -9.81686  3.89914   -14.26723 1.000 19.28300 ? 104 LEU   A N   1 
ATOM   142  C  CA  . LEU   A 1 104 ? -9.92489  5.32472   -13.99198 1.000 16.80467 ? 104 LEU   A CA  1 
ATOM   143  C  C   . LEU   A 1 104 ? -11.34221 5.67806   -13.54874 1.000 15.28207 ? 104 LEU   A C   1 
ATOM   144  O  O   . LEU   A 1 104 ? -12.31593 5.11420   -14.05668 1.000 17.36398 ? 104 LEU   A O   1 
ATOM   145  C  CB  . LEU   A 1 104 ? -9.55771  6.08928   -15.26355 1.000 15.17065 ? 104 LEU   A CB  1 
ATOM   146  C  CG  . LEU   A 1 104 ? -9.72257  7.59823   -15.25530 1.000 15.63732 ? 104 LEU   A CG  1 
ATOM   147  C  CD1 . LEU   A 1 104 ? -8.45169  8.23390   -14.72674 1.000 20.66696 ? 104 LEU   A CD1 1 
ATOM   148  C  CD2 . LEU   A 1 104 ? -10.01282 8.04867   -16.67407 1.000 16.16916 ? 104 LEU   A CD2 1 
ATOM   149  N  N   . HIS   A 1 105 ? -11.45951 6.61813   -12.59969 1.000 18.33280 ? 105 HIS   A N   1 
ATOM   150  C  CA  . HIS   A 1 105 ? -12.76794 7.08867   -12.11776 1.000 17.66665 ? 105 HIS   A CA  1 
ATOM   151  C  C   . HIS   A 1 105 ? -13.42246 8.04607   -13.11232 1.000 15.98863 ? 105 HIS   A C   1 
ATOM   152  O  O   . HIS   A 1 105 ? -13.55148 9.24238   -12.83590 1.000 13.88183 ? 105 HIS   A O   1 
ATOM   153  C  CB  . HIS   A 1 105 ? -12.64736 7.80407   -10.76162 1.000 21.39137 ? 105 HIS   A CB  1 
ATOM   154  C  CG  . HIS   A 1 105 ? -12.04566 6.97572   -9.65756  1.000 32.17459 ? 105 HIS   A CG  1 
ATOM   155  N  ND1 . HIS   A 1 105 ? -11.12213 7.48516   -8.76414  1.000 32.02093 ? 105 HIS   A ND1 1 
ATOM   156  C  CD2 . HIS   A 1 105 ? -12.26899 5.69587   -9.27154  1.000 28.22037 ? 105 HIS   A CD2 1 
ATOM   157  C  CE1 . HIS   A 1 105 ? -10.78467 6.54753   -7.89412  1.000 29.51709 ? 105 HIS   A CE1 1 
ATOM   158  N  NE2 . HIS   A 1 105 ? -11.46820 5.45166   -8.17887  1.000 30.11948 ? 105 HIS   A NE2 1 
ATOM   159  N  N   . VAL   A 1 106 ? -13.84913 7.55049   -14.27354 1.000 15.61499 ? 106 VAL   A N   1 
ATOM   160  C  CA  . VAL   A 1 106 ? -14.19017 8.49381   -15.33882 1.000 13.50573 ? 106 VAL   A CA  1 
ATOM   161  C  C   . VAL   A 1 106 ? -15.44294 9.29378   -14.98444 1.000 15.00652 ? 106 VAL   A C   1 
ATOM   162  O  O   . VAL   A 1 106 ? -15.59512 10.44755  -15.40976 1.000 11.47242 ? 106 VAL   A O   1 
ATOM   163  C  CB  . VAL   A 1 106 ? -14.32979 7.75366   -16.68219 1.000 13.92330 ? 106 VAL   A CB  1 
ATOM   164  C  CG1 . VAL   A 1 106 ? -15.55614 6.82244   -16.67589 1.000 10.93723 ? 106 VAL   A CG1 1 
ATOM   165  C  CG2 . VAL   A 1 106 ? -14.36709 8.75505   -17.85131 1.000 14.33284 ? 106 VAL   A CG2 1 
ATOM   166  N  N   . PHE   A 1 107 ? -16.34100 8.71746   -14.18471 1.000 13.74188 ? 107 PHE   A N   1 
ATOM   167  C  CA  . PHE   A 1 107 ? -17.55404 9.44077   -13.82290 1.000 17.50607 ? 107 PHE   A CA  1 
ATOM   168  C  C   . PHE   A 1 107 ? -17.24203 10.56138  -12.83561 1.000 16.12452 ? 107 PHE   A C   1 
ATOM   169  O  O   . PHE   A 1 107 ? -17.85530 11.63286  -12.89446 1.000 11.23514 ? 107 PHE   A O   1 
ATOM   170  C  CB  . PHE   A 1 107 ? -18.59704 8.47203   -13.25907 1.000 14.76413 ? 107 PHE   A CB  1 
ATOM   171  C  CG  . PHE   A 1 107 ? -19.12552 7.49143   -14.27375 1.000 16.20579 ? 107 PHE   A CG  1 
ATOM   172  C  CD1 . PHE   A 1 107 ? -20.06781 7.87905   -15.21595 1.000 17.38366 ? 107 PHE   A CD1 1 
ATOM   173  C  CD2 . PHE   A 1 107 ? -18.67256 6.18248   -14.28747 1.000 18.32490 ? 107 PHE   A CD2 1 
ATOM   174  C  CE1 . PHE   A 1 107 ? -20.55221 6.96752   -16.15994 1.000 16.49977 ? 107 PHE   A CE1 1 
ATOM   175  C  CE2 . PHE   A 1 107 ? -19.14920 5.27031   -15.20833 1.000 15.94273 ? 107 PHE   A CE2 1 
ATOM   176  C  CZ  . PHE   A 1 107 ? -20.08748 5.66630   -16.16014 1.000 14.38617 ? 107 PHE   A CZ  1 
ATOM   177  N  N   . ARG   A 1 108 ? -16.28191 10.34162  -11.93056 1.000 14.44326 ? 108 ARG   A N   1 
ATOM   178  C  CA  . ARG   A 1 108 ? -15.86302 11.43791  -11.05471 1.000 18.34951 ? 108 ARG   A CA  1 
ATOM   179  C  C   . ARG   A 1 108 ? -15.18449 12.53950  -11.85050 1.000 16.36135 ? 108 ARG   A C   1 
ATOM   180  O  O   . ARG   A 1 108 ? -15.42423 13.72713  -11.61260 1.000 17.90446 ? 108 ARG   A O   1 
ATOM   181  C  CB  . ARG   A 1 108 ? -14.92477 10.93602  -9.96285  1.000 21.41494 ? 108 ARG   A CB  1 
ATOM   182  C  CG  . ARG   A 1 108 ? -15.51245 9.86317   -9.09213  1.000 27.09616 ? 108 ARG   A CG  1 
ATOM   183  C  CD  . ARG   A 1 108 ? -14.65086 9.69406   -7.85809  1.000 28.69849 ? 108 ARG   A CD  1 
ATOM   184  N  NE  . ARG   A 1 108 ? -14.97483 8.47004   -7.13133  1.000 28.52538 ? 108 ARG   A NE  1 
ATOM   185  C  CZ  . ARG   A 1 108 ? -14.12065 7.84766   -6.33032  1.000 29.72864 ? 108 ARG   A CZ  1 
ATOM   186  N  NH1 . ARG   A 1 108 ? -12.89682 8.33880   -6.15751  1.000 25.33830 ? 108 ARG   A NH1 1 
ATOM   187  N  NH2 . ARG   A 1 108 ? -14.48502 6.73394   -5.71496  1.000 31.33410 ? 108 ARG   A NH2 1 
ATOM   188  N  N   . ILE   A 1 109 ? -14.33629 12.15990  -12.80829 1.000 13.76230 ? 109 ILE   A N   1 
ATOM   189  C  CA  . ILE   A 1 109 ? -13.66092 13.14036  -13.64677 1.000 15.37377 ? 109 ILE   A CA  1 
ATOM   190  C  C   . ILE   A 1 109 ? -14.67218 13.96786  -14.43340 1.000 15.73084 ? 109 ILE   A C   1 
ATOM   191  O  O   . ILE   A 1 109 ? -14.49377 15.18211  -14.59554 1.000 14.74655 ? 109 ILE   A O   1 
ATOM   192  C  CB  . ILE   A 1 109 ? -12.64340 12.41528  -14.55543 1.000 16.35945 ? 109 ILE   A CB  1 
ATOM   193  C  CG1 . ILE   A 1 109 ? -11.36543 12.12784  -13.75533 1.000 16.81802 ? 109 ILE   A CG1 1 
ATOM   194  C  CG2 . ILE   A 1 109 ? -12.34606 13.22595  -15.81121 1.000 13.48455 ? 109 ILE   A CG2 1 
ATOM   195  C  CD1 . ILE   A 1 109 ? -10.44335 11.14135  -14.38188 1.000 16.64675 ? 109 ILE   A CD1 1 
ATOM   196  N  N   . ALA   A 1 110 ? -15.76756 13.34471  -14.89516 1.000 16.28811 ? 110 ALA   A N   1 
ATOM   197  C  CA  . ALA   A 1 110 ? -16.79578 14.09694  -15.61117 1.000 14.96638 ? 110 ALA   A CA  1 
ATOM   198  C  C   . ALA   A 1 110 ? -17.43607 15.14255  -14.71066 1.000 19.42925 ? 110 ALA   A C   1 
ATOM   199  O  O   . ALA   A 1 110 ? -17.72590 16.26321  -15.14804 1.000 19.81986 ? 110 ALA   A O   1 
ATOM   200  C  CB  . ALA   A 1 110 ? -17.86828 13.16632  -16.16876 1.000 13.27791 ? 110 ALA   A CB  1 
ATOM   201  N  N   . GLU   A 1 111 ? -17.68926 14.78913  -13.45078 1.000 17.43175 ? 111 GLU   A N   1 
ATOM   202  C  CA  . GLU   A 1 111 ? -18.23833 15.78629  -12.54666 1.000 23.25290 ? 111 GLU   A CA  1 
ATOM   203  C  C   . GLU   A 1 111 ? -17.18102 16.79575  -12.13211 1.000 21.82437 ? 111 GLU   A C   1 
ATOM   204  O  O   . GLU   A 1 111 ? -17.43731 18.00336  -12.12200 1.000 21.86030 ? 111 GLU   A O   1 
ATOM   205  C  CB  . GLU   A 1 111 ? -18.84173 15.14971  -11.30446 1.000 28.43823 ? 111 GLU   A CB  1 
ATOM   206  C  CG  . GLU   A 1 111 ? -19.71660 16.17494  -10.62832 1.000 39.87631 ? 111 GLU   A CG  1 
ATOM   207  C  CD  . GLU   A 1 111 ? -20.45296 17.08146  -11.65225 1.000 54.58859 ? 111 GLU   A CD  1 
ATOM   208  O  OE1 . GLU   A 1 111 ? -21.57260 16.72414  -12.06246 1.000 58.92601 ? 111 GLU   A OE1 1 
ATOM   209  O  OE2 . GLU   A 1 111 ? -19.96541 18.22696  -11.96806 1.000 52.24644 ? 111 GLU   A OE2 1 
ATOM   210  N  N   . LEU   A 1 112 ? -15.98703 16.32335  -11.75526 1.000 18.34239 ? 112 LEU   A N   1 
ATOM   211  C  CA  . LEU   A 1 112 ? -14.97688 17.26228  -11.28262 1.000 19.37935 ? 112 LEU   A CA  1 
ATOM   212  C  C   . LEU   A 1 112 ? -14.61428 18.27553  -12.36033 1.000 22.09555 ? 112 LEU   A C   1 
ATOM   213  O  O   . LEU   A 1 112 ? -14.18994 19.39459  -12.04597 1.000 20.19739 ? 112 LEU   A O   1 
ATOM   214  C  CB  . LEU   A 1 112 ? -13.74007 16.50305  -10.82149 1.000 16.99177 ? 112 LEU   A CB  1 
ATOM   215  C  CG  . LEU   A 1 112 ? -13.95778 15.75808  -9.51320  1.000 21.08940 ? 112 LEU   A CG  1 
ATOM   216  C  CD1 . LEU   A 1 112 ? -12.88763 14.70637  -9.33861  1.000 20.72187 ? 112 LEU   A CD1 1 
ATOM   217  C  CD2 . LEU   A 1 112 ? -13.94360 16.77662  -8.37250  1.000 22.67341 ? 112 LEU   A CD2 1 
ATOM   218  N  N   . SER   A 1 113 ? -14.78816 17.91288  -13.62977 1.000 16.16918 ? 113 SER   A N   1 
ATOM   219  C  CA  . SER   A 1 113 ? -14.35071 18.74343  -14.74052 1.000 18.91037 ? 113 SER   A CA  1 
ATOM   220  C  C   . SER   A 1 113 ? -15.45995 19.63186  -15.28470 1.000 17.04212 ? 113 SER   A C   1 
ATOM   221  O  O   . SER   A 1 113 ? -15.25952 20.28800  -16.31014 1.000 19.97638 ? 113 SER   A O   1 
ATOM   222  C  CB  . SER   A 1 113 ? -13.81543 17.86730  -15.87890 1.000 17.94615 ? 113 SER   A CB  1 
ATOM   223  O  OG  . SER   A 1 113 ? -14.91080 17.26775  -16.55961 1.000 16.52632 ? 113 SER   A OG  1 
ATOM   224  N  N   . GLY   A 1 114 ? -16.62356 19.66154  -14.64483 1.000 20.74144 ? 114 GLY   A N   1 
ATOM   225  C  CA  . GLY   A 1 114 ? -17.70487 20.47544  -15.17923 1.000 22.58265 ? 114 GLY   A CA  1 
ATOM   226  C  C   . GLY   A 1 114 ? -18.31454 19.88914  -16.43766 1.000 20.78484 ? 114 GLY   A C   1 
ATOM   227  O  O   . GLY   A 1 114 ? -18.59730 20.62594  -17.39140 1.000 21.83606 ? 114 GLY   A O   1 
ATOM   228  N  N   . ASN   A 1 115 ? -18.51012 18.57416  -16.45997 1.000 20.09119 ? 115 ASN   A N   1 
ATOM   229  C  CA  . ASN   A 1 115 ? -19.01584 17.84543  -17.62140 1.000 19.73112 ? 115 ASN   A CA  1 
ATOM   230  C  C   . ASN   A 1 115 ? -18.11856 18.03651  -18.84189 1.000 19.21327 ? 115 ASN   A C   1 
ATOM   231  O  O   . ASN   A 1 115 ? -18.59015 18.11674  -19.98004 1.000 19.53046 ? 115 ASN   A O   1 
ATOM   232  C  CB  . ASN   A 1 115 ? -20.46390 18.20820  -17.94477 1.000 23.38130 ? 115 ASN   A CB  1 
ATOM   233  C  CG  . ASN   A 1 115 ? -21.14132 17.11123  -18.72465 1.000 26.36657 ? 115 ASN   A CG  1 
ATOM   234  O  OD1 . ASN   A 1 115 ? -20.67150 15.96601  -18.70763 1.000 25.27209 ? 115 ASN   A OD1 1 
ATOM   235  N  ND2 . ASN   A 1 115 ? -22.22100 17.43788  -19.42448 1.000 20.03635 ? 115 ASN   A ND2 1 
ATOM   236  N  N   . ARG   A 1 116 ? -16.79896 18.07068  -18.60196 1.000 17.26380 ? 116 ARG   A N   1 
ATOM   237  C  CA  . ARG   A 1 116 ? -15.82612 18.05843  -19.68531 1.000 16.69765 ? 116 ARG   A CA  1 
ATOM   238  C  C   . ARG   A 1 116 ? -14.88154 16.85748  -19.60200 1.000 14.26974 ? 116 ARG   A C   1 
ATOM   239  O  O   . ARG   A 1 116 ? -13.67499 17.03081  -19.79706 1.000 12.27256 ? 116 ARG   A O   1 
ATOM   240  C  CB  . ARG   A 1 116 ? -15.02228 19.36841  -19.67791 1.000 14.31758 ? 116 ARG   A CB  1 
ATOM   241  C  CG  . ARG   A 1 116 ? -15.89142 20.60734  -19.92153 1.000 19.94047 ? 116 ARG   A CG  1 
ATOM   242  C  CD  . ARG   A 1 116 ? -15.99699 20.94942  -21.41089 1.000 25.23478 ? 116 ARG   A CD  1 
ATOM   243  N  NE  . ARG   A 1 116 ? -17.34220 20.75869  -21.95518 1.000 33.36574 ? 116 ARG   A NE  1 
ATOM   244  C  CZ  . ARG   A 1 116 ? -17.68733 20.97488  -23.23143 1.000 35.34874 ? 116 ARG   A CZ  1 
ATOM   245  N  NH1 . ARG   A 1 116 ? -16.78731 21.39733  -24.10328 1.000 27.77880 ? 116 ARG   A NH1 1 
ATOM   246  N  NH2 . ARG   A 1 116 ? -18.93922 20.76494  -23.64218 1.000 32.40553 ? 116 ARG   A NH2 1 
ATOM   247  N  N   . PRO   A 1 117 ? -15.36593 15.63199  -19.33627 1.000 13.24937 ? 117 PRO   A N   1 
ATOM   248  C  CA  . PRO   A 1 117 ? -14.42360 14.49150  -19.28288 1.000 13.25695 ? 117 PRO   A CA  1 
ATOM   249  C  C   . PRO   A 1 117 ? -13.64877 14.27894  -20.56974 1.000 11.81960 ? 117 PRO   A C   1 
ATOM   250  O  O   . PRO   A 1 117 ? -12.47313 13.91869  -20.50279 1.000 13.37349 ? 117 PRO   A O   1 
ATOM   251  C  CB  . PRO   A 1 117 ? -15.33632 13.29260  -18.98807 1.000 13.39978 ? 117 PRO   A CB  1 
ATOM   252  C  CG  . PRO   A 1 117 ? -16.65242 13.69129  -19.58324 1.000 11.02929 ? 117 PRO   A CG  1 
ATOM   253  C  CD  . PRO   A 1 117 ? -16.75589 15.16417  -19.20664 1.000 12.94624 ? 117 PRO   A CD  1 
ATOM   254  N  N   . LEU   A 1 118 ? -14.27094 14.46382  -21.74065 1.000 12.51104 ? 118 LEU   A N   1 
ATOM   255  C  CA  . LEU   A 1 118 ? -13.55822 14.19871  -22.99094 1.000 13.30890 ? 118 LEU   A CA  1 
ATOM   256  C  C   . LEU   A 1 118 ? -12.44671 15.21562  -23.20497 1.000 14.30999 ? 118 LEU   A C   1 
ATOM   257  O  O   . LEU   A 1 118 ? -11.31966 14.84173  -23.54693 1.000 9.55062  ? 118 LEU   A O   1 
ATOM   258  C  CB  . LEU   A 1 118 ? -14.51812 14.19638  -24.18697 1.000 11.35358 ? 118 LEU   A CB  1 
ATOM   259  C  CG  . LEU   A 1 118 ? -13.93118 13.89328  -25.58654 1.000 11.78054 ? 118 LEU   A CG  1 
ATOM   260  C  CD1 . LEU   A 1 118 ? -13.25291 12.52139  -25.65750 1.000 11.22183 ? 118 LEU   A CD1 1 
ATOM   261  C  CD2 . LEU   A 1 118 ? -14.98416 13.99527  -26.68211 1.000 9.46299  ? 118 LEU   A CD2 1 
ATOM   262  N  N   . THR   A 1 119 ? -12.73241 16.50136  -22.97873 1.000 9.73280  ? 119 THR   A N   1 
ATOM   263  C  CA  . THR   A 1 119 ? -11.68851 17.51489  -23.14295 1.000 14.74068 ? 119 THR   A CA  1 
ATOM   264  C  C   . THR   A 1 119 ? -10.51277 17.26826  -22.19845 1.000 12.14441 ? 119 THR   A C   1 
ATOM   265  O  O   . THR   A 1 119 ? -9.35144  17.26305  -22.62800 1.000 13.41720 ? 119 THR   A O   1 
ATOM   266  C  CB  . THR   A 1 119 ? -12.26238 18.92261  -22.93532 1.000 15.26608 ? 119 THR   A CB  1 
ATOM   267  O  OG1 . THR   A 1 119 ? -13.23277 19.19758  -23.95505 1.000 15.51195 ? 119 THR   A OG1 1 
ATOM   268  C  CG2 . THR   A 1 119 ? -11.13727 19.97966  -23.01647 1.000 14.26247 ? 119 THR   A CG2 1 
ATOM   269  N  N   . VAL   A 1 120 ? -10.78419 17.05625  -20.90547 1.000 14.49470 ? 120 VAL   A N   1 
ATOM   270  C  CA  . VAL   A 1 120 ? -9.66597  17.01090  -19.96341 1.000 13.84906 ? 120 VAL   A CA  1 
ATOM   271  C  C   . VAL   A 1 120 ? -8.86360  15.72289  -20.13507 1.000 13.45393 ? 120 VAL   A C   1 
ATOM   272  O  O   . VAL   A 1 120 ? -7.63032  15.73233  -20.02551 1.000 10.98401 ? 120 VAL   A O   1 
ATOM   273  C  CB  . VAL   A 1 120 ? -10.13939 17.22108  -18.50435 1.000 17.92651 ? 120 VAL   A CB  1 
ATOM   274  C  CG1 . VAL   A 1 120 ? -10.79791 18.59471  -18.33932 1.000 14.55317 ? 120 VAL   A CG1 1 
ATOM   275  C  CG2 . VAL   A 1 120 ? -11.08451 16.10319  -18.04068 1.000 13.60905 ? 120 VAL   A CG2 1 
ATOM   276  N  N   . ILE   A 1 121 ? -9.53373  14.60680  -20.44927 1.000 10.97315 ? 121 ILE   A N   1 
ATOM   277  C  CA  . ILE   A 1 121 ? -8.81526  13.33787  -20.58149 1.000 9.86165  ? 121 ILE   A CA  1 
ATOM   278  C  C   . ILE   A 1 121 ? -7.98260  13.31747  -21.86001 1.000 10.39457 ? 121 ILE   A C   1 
ATOM   279  O  O   . ILE   A 1 121 ? -6.82481  12.88106  -21.85530 1.000 15.60563 ? 121 ILE   A O   1 
ATOM   280  C  CB  . ILE   A 1 121 ? -9.81727  12.16815  -20.49212 1.000 12.79245 ? 121 ILE   A CB  1 
ATOM   281  C  CG1 . ILE   A 1 121 ? -10.13392 11.91125  -19.01986 1.000 10.31401 ? 121 ILE   A CG1 1 
ATOM   282  C  CG2 . ILE   A 1 121 ? -9.30373  10.90133  -21.20967 1.000 12.55061 ? 121 ILE   A CG2 1 
ATOM   283  C  CD1 . ILE   A 1 121 ? -11.34755 11.00265  -18.77056 1.000 12.85741 ? 121 ILE   A CD1 1 
ATOM   284  N  N   . MET   A 1 122 ? -8.53968  13.81255  -22.96849 1.000 11.07834 ? 122 MET   A N   1 
ATOM   285  C  CA  . MET   A 1 122 ? -7.77126  13.94005  -24.20863 1.000 10.04457 ? 122 MET   A CA  1 
ATOM   286  C  C   . MET   A 1 122 ? -6.57534  14.87359  -24.03202 1.000 12.43200 ? 122 MET   A C   1 
ATOM   287  O  O   . MET   A 1 122 ? -5.44935  14.55075  -24.43433 1.000 11.27006 ? 122 MET   A O   1 
ATOM   288  C  CB  . MET   A 1 122 ? -8.68083  14.44210  -25.33095 1.000 10.36202 ? 122 MET   A CB  1 
ATOM   289  C  CG  . MET   A 1 122 ? -9.54919  13.34711  -25.95018 1.000 11.44753 ? 122 MET   A CG  1 
ATOM   290  S  SD  . MET   A 1 122 ? -8.67118  12.34949  -27.20225 1.000 11.83495 ? 122 MET   A SD  1 
ATOM   291  C  CE  . MET   A 1 122 ? -8.65453  13.44028  -28.62296 1.000 8.30048  ? 122 MET   A CE  1 
ATOM   292  N  N   . HIS   A 1 123 ? -6.79837  16.04324  -23.43704 1.000 13.28465 ? 123 HIS   A N   1 
ATOM   293  C  CA  . HIS   A 1 123 ? -5.67906  16.95617  -23.22890 1.000 15.09631 ? 123 HIS   A CA  1 
ATOM   294  C  C   . HIS   A 1 123 ? -4.60249  16.29951  -22.36433 1.000 13.62794 ? 123 HIS   A C   1 
ATOM   295  O  O   . HIS   A 1 123 ? -3.41685  16.34707  -22.69617 1.000 13.88912 ? 123 HIS   A O   1 
ATOM   296  C  CB  . HIS   A 1 123 ? -6.18264  18.26337  -22.61436 1.000 17.24177 ? 123 HIS   A CB  1 
ATOM   297  C  CG  . HIS   A 1 123 ? -5.09544  19.23884  -22.28672 1.000 20.83643 ? 123 HIS   A CG  1 
ATOM   298  N  ND1 . HIS   A 1 123 ? -4.29953  19.82267  -23.24811 1.000 29.67233 ? 123 HIS   A ND1 1 
ATOM   299  C  CD2 . HIS   A 1 123 ? -4.66187  19.71965  -21.09742 1.000 31.77293 ? 123 HIS   A CD2 1 
ATOM   300  C  CE1 . HIS   A 1 123 ? -3.42630  20.62641  -22.66814 1.000 29.73843 ? 123 HIS   A CE1 1 
ATOM   301  N  NE2 . HIS   A 1 123 ? -3.62518  20.58283  -21.36232 1.000 40.34283 ? 123 HIS   A NE2 1 
ATOM   302  N  N   . THR   A 1 124 ? -5.00885  15.61959  -21.29040 1.000 14.00755 ? 124 THR   A N   1 
ATOM   303  C  CA  . THR   A 1 124 ? -4.04828  14.92330  -20.43721 1.000 14.05034 ? 124 THR   A CA  1 
ATOM   304  C  C   . THR   A 1 124 ? -3.25746  13.87953  -21.21508 1.000 14.54300 ? 124 THR   A C   1 
ATOM   305  O  O   . THR   A 1 124 ? -2.02711  13.79108  -21.08041 1.000 13.85321 ? 124 THR   A O   1 
ATOM   306  C  CB  . THR   A 1 124 ? -4.77647  14.26608  -19.25900 1.000 14.71254 ? 124 THR   A CB  1 
ATOM   307  O  OG1 . THR   A 1 124 ? -5.42873  15.27654  -18.47680 1.000 14.59636 ? 124 THR   A OG1 1 
ATOM   308  C  CG2 . THR   A 1 124 ? -3.78880  13.48914  -18.37974 1.000 12.70544 ? 124 THR   A CG2 1 
ATOM   309  N  N   . ILE   A 1 125 ? -3.94528  13.08814  -22.04703 1.000 12.58114 ? 125 ILE   A N   1 
ATOM   310  C  CA  . ILE   A 1 125 ? -3.28369  12.02630  -22.80385 1.000 13.27833 ? 125 ILE   A CA  1 
ATOM   311  C  C   . ILE   A 1 125 ? -2.35633  12.59847  -23.87497 1.000 15.03112 ? 125 ILE   A C   1 
ATOM   312  O  O   . ILE   A 1 125 ? -1.25705  12.07225  -24.10132 1.000 16.19915 ? 125 ILE   A O   1 
ATOM   313  C  CB  . ILE   A 1 125 ? -4.33947  11.07408  -23.40334 1.000 15.55078 ? 125 ILE   A CB  1 
ATOM   314  C  CG1 . ILE   A 1 125 ? -4.94851  10.23022  -22.27817 1.000 15.71703 ? 125 ILE   A CG1 1 
ATOM   315  C  CG2 . ILE   A 1 125 ? -3.73257  10.21764  -24.52523 1.000 12.35410 ? 125 ILE   A CG2 1 
ATOM   316  C  CD1 . ILE   A 1 125 ? -6.18060  9.42186   -22.68463 1.000 15.53856 ? 125 ILE   A CD1 1 
ATOM   317  N  N   . PHE   A 1 126 ? -2.76983  13.67136  -24.56062 1.000 12.73040 ? 126 PHE   A N   1 
ATOM   318  C  CA  . PHE   A 1 126 ? -1.87455  14.26408  -25.55820 1.000 15.66527 ? 126 PHE   A CA  1 
ATOM   319  C  C   . PHE   A 1 126 ? -0.59210  14.77340  -24.90563 1.000 17.54412 ? 126 PHE   A C   1 
ATOM   320  O  O   . PHE   A 1 126 ? 0.50182   14.61763  -25.46551 1.000 16.96710 ? 126 PHE   A O   1 
ATOM   321  C  CB  . PHE   A 1 126 ? -2.56753  15.40347  -26.32533 1.000 13.47161 ? 126 PHE   A CB  1 
ATOM   322  C  CG  . PHE   A 1 126 ? -3.34643  14.94960  -27.55491 1.000 13.01492 ? 126 PHE   A CG  1 
ATOM   323  C  CD1 . PHE   A 1 126 ? -4.29635  13.93662  -27.46272 1.000 12.34224 ? 126 PHE   A CD1 1 
ATOM   324  C  CD2 . PHE   A 1 126 ? -3.15599  15.56071  -28.79076 1.000 13.83268 ? 126 PHE   A CD2 1 
ATOM   325  C  CE1 . PHE   A 1 126 ? -5.02792  13.52823  -28.58080 1.000 10.98948 ? 126 PHE   A CE1 1 
ATOM   326  C  CE2 . PHE   A 1 126 ? -3.88701  15.15202  -29.92128 1.000 13.86856 ? 126 PHE   A CE2 1 
ATOM   327  C  CZ  . PHE   A 1 126 ? -4.81741  14.13414  -29.80697 1.000 9.86096  ? 126 PHE   A CZ  1 
ATOM   328  N  N   . GLN   A 1 127 ? -0.70234  15.38189  -23.71934 1.000 15.98981 ? 127 GLN   A N   1 
ATOM   329  C  CA  . GLN   A 1 127 ? 0.50522   15.85167  -23.03890 1.000 20.21669 ? 127 GLN   A CA  1 
ATOM   330  C  C   . GLN   A 1 127 ? 1.33736   14.67887  -22.54137 1.000 20.82409 ? 127 GLN   A C   1 
ATOM   331  O  O   . GLN   A 1 127 ? 2.56720   14.67539  -22.68566 1.000 18.23749 ? 127 GLN   A O   1 
ATOM   332  C  CB  . GLN   A 1 127 ? 0.14378   16.78703  -21.87881 1.000 22.78798 ? 127 GLN   A CB  1 
ATOM   333  C  CG  . GLN   A 1 127 ? -0.51956  18.07055  -22.35265 1.000 26.95513 ? 127 GLN   A CG  1 
ATOM   334  C  CD  . GLN   A 1 127 ? 0.43933   19.25200  -22.35368 1.000 46.01328 ? 127 GLN   A CD  1 
ATOM   335  O  OE1 . GLN   A 1 127 ? 1.67233   19.06345  -22.38513 1.000 43.97137 ? 127 GLN   A OE1 1 
ATOM   336  N  NE2 . GLN   A 1 127 ? -0.12092  20.47652  -22.37605 1.000 37.08604 ? 127 GLN   A NE2 1 
ATOM   337  N  N   . GLU   A 1 128 ? 0.67876   13.65571  -21.98619 1.000 17.83341 ? 128 GLU   A N   1 
ATOM   338  C  CA  . GLU   A 1 128 ? 1.39551   12.47427  -21.51651 1.000 21.35036 ? 128 GLU   A CA  1 
ATOM   339  C  C   . GLU   A 1 128 ? 2.18453   11.80409  -22.63982 1.000 21.62275 ? 128 GLU   A C   1 
ATOM   340  O  O   . GLU   A 1 128 ? 3.30724   11.33782  -22.41979 1.000 21.87588 ? 128 GLU   A O   1 
ATOM   341  C  CB  . GLU   A 1 128 ? 0.40851   11.49583  -20.87841 1.000 22.24308 ? 128 GLU   A CB  1 
ATOM   342  C  CG  . GLU   A 1 128 ? 1.00695   10.14972  -20.50052 1.000 27.10378 ? 128 GLU   A CG  1 
ATOM   343  C  CD  . GLU   A 1 128 ? 1.76511   10.17542  -19.18522 1.000 30.54478 ? 128 GLU   A CD  1 
ATOM   344  O  OE1 . GLU   A 1 128 ? 2.22602   9.09436   -18.76462 1.000 32.38779 ? 128 GLU   A OE1 1 
ATOM   345  O  OE2 . GLU   A 1 128 ? 1.89766   11.26114  -18.57612 1.000 30.17879 ? 128 GLU   A OE2 1 
ATOM   346  N  N   . ARG   A 1 129 ? 1.62693   11.74861  -23.84992 1.000 17.01073 ? 129 ARG   A N   1 
ATOM   347  C  CA  . ARG   A 1 129 ? 2.30992   11.13442  -24.98584 1.000 17.73941 ? 129 ARG   A CA  1 
ATOM   348  C  C   . ARG   A 1 129 ? 3.12499   12.13022  -25.80192 1.000 17.66658 ? 129 ARG   A C   1 
ATOM   349  O  O   . ARG   A 1 129 ? 3.62359   11.76774  -26.86909 1.000 18.86417 ? 129 ARG   A O   1 
ATOM   350  C  CB  . ARG   A 1 129 ? 1.29467   10.43859  -25.90092 1.000 16.01408 ? 129 ARG   A CB  1 
ATOM   351  C  CG  . ARG   A 1 129 ? 0.59980   9.23937   -25.26235 1.000 15.69466 ? 129 ARG   A CG  1 
ATOM   352  C  CD  . ARG   A 1 129 ? -0.26819  8.47689   -26.27535 1.000 16.47845 ? 129 ARG   A CD  1 
ATOM   353  N  NE  . ARG   A 1 129 ? -0.74303  7.21329   -25.69615 1.000 15.13166 ? 129 ARG   A NE  1 
ATOM   354  C  CZ  . ARG   A 1 129 ? -0.06947  6.07269   -25.77255 1.000 20.31204 ? 129 ARG   A CZ  1 
ATOM   355  N  NH1 . ARG   A 1 129 ? 1.10492   6.03226   -26.40640 1.000 19.73169 ? 129 ARG   A NH1 1 
ATOM   356  N  NH2 . ARG   A 1 129 ? -0.55214  4.97738   -25.20519 1.000 17.63919 ? 129 ARG   A NH2 1 
ATOM   357  N  N   . ASP   A 1 130 ? 3.23840   13.37816  -25.34483 1.000 17.70872 ? 130 ASP   A N   1 
ATOM   358  C  CA  . ASP   A 1 130 ? 4.01881   14.41240  -26.02210 1.000 20.03370 ? 130 ASP   A CA  1 
ATOM   359  C  C   . ASP   A 1 130 ? 3.51089   14.66956  -27.43764 1.000 22.29635 ? 130 ASP   A C   1 
ATOM   360  O  O   . ASP   A 1 130 ? 4.28171   15.00145  -28.34181 1.000 18.51760 ? 130 ASP   A O   1 
ATOM   361  C  CB  . ASP   A 1 130 ? 5.50723   14.04938  -26.03550 1.000 23.53127 ? 130 ASP   A CB  1 
ATOM   362  C  CG  . ASP   A 1 130 ? 6.40394   15.27361  -25.99162 1.000 29.03644 ? 130 ASP   A CG  1 
ATOM   363  O  OD1 . ASP   A 1 130 ? 5.92573   16.34561  -25.56134 1.000 26.49636 ? 130 ASP   A OD1 1 
ATOM   364  O  OD2 . ASP   A 1 130 ? 7.58512   15.15723  -26.39039 1.000 34.80368 ? 130 ASP   A OD2 1 
ATOM   365  N  N   . LEU   A 1 131 ? 2.19955   14.52211  -27.63537 1.000 16.28455 ? 131 LEU   A N   1 
ATOM   366  C  CA  . LEU   A 1 131 ? 1.63324   14.63636  -28.96950 1.000 16.39928 ? 131 LEU   A CA  1 
ATOM   367  C  C   . LEU   A 1 131 ? 1.59958   16.08024  -29.45938 1.000 17.60777 ? 131 LEU   A C   1 
ATOM   368  O  O   . LEU   A 1 131 ? 1.76340   16.31064  -30.65757 1.000 16.81894 ? 131 LEU   A O   1 
ATOM   369  C  CB  . LEU   A 1 131 ? 0.22706   14.01164  -29.00144 1.000 16.75522 ? 131 LEU   A CB  1 
ATOM   370  C  CG  . LEU   A 1 131 ? 0.22374   12.47304  -28.99558 1.000 14.35904 ? 131 LEU   A CG  1 
ATOM   371  C  CD1 . LEU   A 1 131 ? -1.18601  11.88906  -28.83041 1.000 14.46567 ? 131 LEU   A CD1 1 
ATOM   372  C  CD2 . LEU   A 1 131 ? 0.89019   11.93104  -30.27227 1.000 12.78865 ? 131 LEU   A CD2 1 
ATOM   373  N  N   . LEU   A 1 132 ? 1.37950   17.06324  -28.57276 1.000 17.82708 ? 132 LEU   A N   1 
ATOM   374  C  CA  . LEU   A 1 132 ? 1.35942   18.45459  -29.03249 1.000 17.64524 ? 132 LEU   A CA  1 
ATOM   375  C  C   . LEU   A 1 132 ? 2.69808   18.85305  -29.65622 1.000 18.89869 ? 132 LEU   A C   1 
ATOM   376  O  O   . LEU   A 1 132 ? 2.73123   19.50171  -30.70974 1.000 21.12430 ? 132 LEU   A O   1 
ATOM   377  C  CB  . LEU   A 1 132 ? 1.00197   19.39498  -27.88369 1.000 20.22159 ? 132 LEU   A CB  1 
ATOM   378  C  CG  . LEU   A 1 132 ? -0.39855  19.24273  -27.28318 1.000 20.17084 ? 132 LEU   A CG  1 
ATOM   379  C  CD1 . LEU   A 1 132 ? -0.35987  18.30351  -26.08084 1.000 15.79953 ? 132 LEU   A CD1 1 
ATOM   380  C  CD2 . LEU   A 1 132 ? -0.96707  20.59555  -26.88539 1.000 19.09366 ? 132 LEU   A CD2 1 
ATOM   381  N  N   . LYS   A 1 133 ? 3.80951   18.46076  -29.02644 1.000 20.01317 ? 133 LYS   A N   1 
ATOM   382  C  CA  . LYS   A 1 133 ? 5.13307   18.75095  -29.57590 1.000 21.63131 ? 133 LYS   A CA  1 
ATOM   383  C  C   . LYS   A 1 133 ? 5.38749   17.96977  -30.85747 1.000 23.31859 ? 133 LYS   A C   1 
ATOM   384  O  O   . LYS   A 1 133 ? 5.83636   18.53514  -31.86493 1.000 19.80386 ? 133 LYS   A O   1 
ATOM   385  C  CB  . LYS   A 1 133 ? 6.21607   18.42865  -28.54340 1.000 23.63127 ? 133 LYS   A CB  1 
ATOM   386  C  CG  . LYS   A 1 133 ? 6.11311   19.25060  -27.27665 1.000 34.70060 ? 133 LYS   A CG  1 
ATOM   387  C  CD  . LYS   A 1 133 ? 7.45723   19.86360  -26.88215 1.000 41.80106 ? 133 LYS   A CD  1 
ATOM   388  C  CE  . LYS   A 1 133 ? 7.25795   21.08404  -25.97863 1.000 40.44913 ? 133 LYS   A CE  1 
ATOM   389  N  NZ  . LYS   A 1 133 ? 8.54019   21.61962  -25.41526 1.000 45.88162 ? 133 LYS   A NZ  1 
ATOM   390  N  N   . THR   A 1 134 ? 5.10961   16.66382  -30.83754 1.000 20.41672 ? 134 THR   A N   1 
ATOM   391  C  CA  . THR   A 1 134 ? 5.41703   15.82353  -31.99315 1.000 20.64596 ? 134 THR   A CA  1 
ATOM   392  C  C   . THR   A 1 134 ? 4.72056   16.33312  -33.25372 1.000 18.31702 ? 134 THR   A C   1 
ATOM   393  O  O   . THR   A 1 134 ? 5.33604   16.41699  -34.32270 1.000 20.62771 ? 134 THR   A O   1 
ATOM   394  C  CB  . THR   A 1 134 ? 5.03083   14.37370  -31.68739 1.000 19.28776 ? 134 THR   A CB  1 
ATOM   395  O  OG1 . THR   A 1 134 ? 5.83394   13.89986  -30.59824 1.000 21.23831 ? 134 THR   A OG1 1 
ATOM   396  C  CG2 . THR   A 1 134 ? 5.23940   13.46829  -32.90360 1.000 19.54142 ? 134 THR   A CG2 1 
ATOM   397  N  N   . PHE   A 1 135 ? 3.45618   16.73041  -33.14092 1.000 17.19018 ? 135 PHE   A N   1 
ATOM   398  C  CA  . PHE   A 1 135 ? 2.68965   17.12876  -34.30912 1.000 18.20274 ? 135 PHE   A CA  1 
ATOM   399  C  C   . PHE   A 1 135 ? 2.43670   18.62635  -34.37096 1.000 17.08587 ? 135 PHE   A C   1 
ATOM   400  O  O   . PHE   A 1 135 ? 1.64205   19.07806  -35.20417 1.000 17.39187 ? 135 PHE   A O   1 
ATOM   401  C  CB  . PHE   A 1 135 ? 1.38237   16.33571  -34.35970 1.000 16.48171 ? 135 PHE   A CB  1 
ATOM   402  C  CG  . PHE   A 1 135 ? 1.60274   14.89249  -34.66725 1.000 12.38015 ? 135 PHE   A CG  1 
ATOM   403  C  CD1 . PHE   A 1 135 ? 1.94771   14.50367  -35.95280 1.000 13.35102 ? 135 PHE   A CD1 1 
ATOM   404  C  CD2 . PHE   A 1 135 ? 1.51230   13.92741  -33.67796 1.000 14.06327 ? 135 PHE   A CD2 1 
ATOM   405  C  CE1 . PHE   A 1 135 ? 2.17711   13.18407  -36.24960 1.000 16.51958 ? 135 PHE   A CE1 1 
ATOM   406  C  CE2 . PHE   A 1 135 ? 1.73164   12.59641  -33.97879 1.000 12.93827 ? 135 PHE   A CE2 1 
ATOM   407  C  CZ  . PHE   A 1 135 ? 2.06700   12.22538  -35.25500 1.000 14.39326 ? 135 PHE   A CZ  1 
ATOM   408  N  N   . LYS   A 1 136 ? 3.11505   19.40607  -33.53255 1.000 20.19773 ? 136 LYS   A N   1 
ATOM   409  C  CA  . LYS   A 1 136 ? 3.04468   20.86639  -33.57945 1.000 23.88778 ? 136 LYS   A CA  1 
ATOM   410  C  C   . LYS   A 1 136 ? 1.60472   21.34451  -33.43072 1.000 16.66635 ? 136 LYS   A C   1 
ATOM   411  O  O   . LYS   A 1 136 ? 1.13216   22.20419  -34.17228 1.000 17.52965 ? 136 LYS   A O   1 
ATOM   412  C  CB  . LYS   A 1 136 ? 3.66117   21.41849  -34.87353 1.000 17.28639 ? 136 LYS   A CB  1 
ATOM   413  C  CG  . LYS   A 1 136 ? 5.16636   21.22787  -35.02950 1.000 27.82475 ? 136 LYS   A CG  1 
ATOM   414  C  CD  . LYS   A 1 136 ? 5.84955   21.30231  -33.67695 1.000 31.76094 ? 136 LYS   A CD  1 
ATOM   415  C  CE  . LYS   A 1 136 ? 7.30698   20.84698  -33.72247 1.000 47.73067 ? 136 LYS   A CE  1 
ATOM   416  N  NZ  . LYS   A 1 136 ? 7.89555   20.87187  -32.34294 1.000 46.19047 ? 136 LYS   A NZ  1 
ATOM   417  N  N   . ILE   A 1 137 ? 0.89379   20.78735  -32.45482 1.000 16.52296 ? 137 ILE   A N   1 
ATOM   418  C  CA  . ILE   A 1 137 ? -0.49714  21.14370  -32.20005 1.000 15.28107 ? 137 ILE   A CA  1 
ATOM   419  C  C   . ILE   A 1 137 ? -0.50804  22.32675  -31.23083 1.000 16.31250 ? 137 ILE   A C   1 
ATOM   420  O  O   . ILE   A 1 137 ? -0.06623  22.16541  -30.07986 1.000 16.28871 ? 137 ILE   A O   1 
ATOM   421  C  CB  . ILE   A 1 137 ? -1.29260  19.95923  -31.63519 1.000 15.07823 ? 137 ILE   A CB  1 
ATOM   422  C  CG1 . ILE   A 1 137 ? -1.16231  18.74835  -32.55912 1.000 16.96377 ? 137 ILE   A CG1 1 
ATOM   423  C  CG2 . ILE   A 1 137 ? -2.76634  20.32902  -31.48319 1.000 13.60313 ? 137 ILE   A CG2 1 
ATOM   424  C  CD1 . ILE   A 1 137 ? -1.78493  17.47462  -31.97582 1.000 15.85168 ? 137 ILE   A CD1 1 
ATOM   425  N  N   . PRO   A 1 138 ? -1.00296  23.50372  -31.63381 1.000 17.65906 ? 138 PRO   A N   1 
ATOM   426  C  CA  . PRO   A 1 138 ? -1.19803  24.58673  -30.66256 1.000 19.83617 ? 138 PRO   A CA  1 
ATOM   427  C  C   . PRO   A 1 138 ? -2.16895  24.15630  -29.57215 1.000 20.97797 ? 138 PRO   A C   1 
ATOM   428  O  O   . PRO   A 1 138 ? -3.21424  23.55408  -29.84436 1.000 19.63637 ? 138 PRO   A O   1 
ATOM   429  C  CB  . PRO   A 1 138 ? -1.77180  25.73437  -31.50656 1.000 22.26357 ? 138 PRO   A CB  1 
ATOM   430  C  CG  . PRO   A 1 138 ? -1.38437  25.40574  -32.92531 1.000 24.12871 ? 138 PRO   A CG  1 
ATOM   431  C  CD  . PRO   A 1 138 ? -1.37744  23.90656  -33.00420 1.000 19.36525 ? 138 PRO   A CD  1 
ATOM   432  N  N   . VAL   A 1 139 ? -1.81648  24.48070  -28.32646 1.000 16.79006 ? 139 VAL   A N   1 
ATOM   433  C  CA  . VAL   A 1 139 ? -2.61688  24.04422  -27.18730 1.000 18.47683 ? 139 VAL   A CA  1 
ATOM   434  C  C   . VAL   A 1 139 ? -4.02272  24.64297  -27.23843 1.000 19.02788 ? 139 VAL   A C   1 
ATOM   435  O  O   . VAL   A 1 139 ? -5.01095  23.95705  -26.94076 1.000 18.91830 ? 139 VAL   A O   1 
ATOM   436  C  CB  . VAL   A 1 139 ? -1.88250  24.37418  -25.86981 1.000 22.77059 ? 139 VAL   A CB  1 
ATOM   437  C  CG1 . VAL   A 1 139 ? -1.64965  25.87728  -25.72455 1.000 23.74857 ? 139 VAL   A CG1 1 
ATOM   438  C  CG2 . VAL   A 1 139 ? -2.62279  23.78900  -24.66867 1.000 25.96780 ? 139 VAL   A CG2 1 
ATOM   439  N  N   . ASP   A 1 140 ? -4.14698  25.91719  -27.63076 1.000 17.38814 ? 140 ASP   A N   1 
ATOM   440  C  CA  . ASP   A 1 140 ? -5.46876  26.53987  -27.71219 1.000 18.60108 ? 140 ASP   A CA  1 
ATOM   441  C  C   . ASP   A 1 140 ? -6.31042  25.90770  -28.81588 1.000 18.42247 ? 140 ASP   A C   1 
ATOM   442  O  O   . ASP   A 1 140 ? -7.53327  25.77157  -28.67192 1.000 16.01251 ? 140 ASP   A O   1 
ATOM   443  C  CB  . ASP   A 1 140 ? -5.33296  28.04477  -27.94689 1.000 20.37443 ? 140 ASP   A CB  1 
ATOM   444  C  CG  . ASP   A 1 140 ? -4.36320  28.37268  -29.07538 1.000 29.63914 ? 140 ASP   A CG  1 
ATOM   445  O  OD1 . ASP   A 1 140 ? -3.17948  27.96359  -28.98209 1.000 35.20802 ? 140 ASP   A OD1 1 
ATOM   446  O  OD2 . ASP   A 1 140 ? -4.77886  29.02523  -30.06130 1.000 37.81073 ? 140 ASP   A OD2 1 
ATOM   447  N  N   . THR   A 1 141 ? -5.67372  25.52944  -29.92693 1.000 16.16559 ? 141 THR   A N   1 
ATOM   448  C  CA  . THR   A 1 141 ? -6.38481  24.83121  -30.99622 1.000 19.14562 ? 141 THR   A CA  1 
ATOM   449  C  C   . THR   A 1 141 ? -6.89706  23.47928  -30.51889 1.000 15.52451 ? 141 THR   A C   1 
ATOM   450  O  O   . THR   A 1 141 ? -8.04559  23.10634  -30.79007 1.000 16.64842 ? 141 THR   A O   1 
ATOM   451  C  CB  . THR   A 1 141 ? -5.47564  24.63568  -32.21222 1.000 18.40351 ? 141 THR   A CB  1 
ATOM   452  O  OG1 . THR   A 1 141 ? -4.87076  25.88148  -32.58312 1.000 22.22424 ? 141 THR   A OG1 1 
ATOM   453  C  CG2 . THR   A 1 141 ? -6.28211  24.10240  -33.39480 1.000 17.13927 ? 141 THR   A CG2 1 
ATOM   454  N  N   . LEU   A 1 142 ? -6.04804  22.72623  -29.82182 1.000 15.73407 ? 142 LEU   A N   1 
ATOM   455  C  CA  . LEU   A 1 142 ? -6.46233  21.44401  -29.27051 1.000 14.97151 ? 142 LEU   A CA  1 
ATOM   456  C  C   . LEU   A 1 142 ? -7.64769  21.60782  -28.31700 1.000 17.35169 ? 142 LEU   A C   1 
ATOM   457  O  O   . LEU   A 1 142 ? -8.64477  20.88374  -28.41784 1.000 15.30679 ? 142 LEU   A O   1 
ATOM   458  C  CB  . LEU   A 1 142 ? -5.27550  20.78709  -28.57018 1.000 12.86796 ? 142 LEU   A CB  1 
ATOM   459  C  CG  . LEU   A 1 142 ? -5.61838  19.49705  -27.82272 1.000 14.77323 ? 142 LEU   A CG  1 
ATOM   460  C  CD1 . LEU   A 1 142 ? -6.11629  18.43805  -28.79887 1.000 12.04371 ? 142 LEU   A CD1 1 
ATOM   461  C  CD2 . LEU   A 1 142 ? -4.40222  19.01997  -27.06998 1.000 16.10251 ? 142 LEU   A CD2 1 
ATOM   462  N  N   . ILE   A 1 143 ? -7.56042  22.56183  -27.38186 1.000 18.48841 ? 143 ILE   A N   1 
ATOM   463  C  CA  . ILE   A 1 143 ? -8.66791  22.78400  -26.44865 1.000 14.76927 ? 143 ILE   A CA  1 
ATOM   464  C  C   . ILE   A 1 143 ? -9.93055  23.20516  -27.20085 1.000 14.85599 ? 143 ILE   A C   1 
ATOM   465  O  O   . ILE   A 1 143 ? -11.04855 22.79635  -26.85603 1.000 15.82455 ? 143 ILE   A O   1 
ATOM   466  C  CB  . ILE   A 1 143 ? -8.28728  23.83042  -25.37951 1.000 16.86639 ? 143 ILE   A CB  1 
ATOM   467  C  CG1 . ILE   A 1 143 ? -7.04724  23.41457  -24.58052 1.000 19.51500 ? 143 ILE   A CG1 1 
ATOM   468  C  CG2 . ILE   A 1 143 ? -9.45749  24.07679  -24.44000 1.000 18.42209 ? 143 ILE   A CG2 1 
ATOM   469  C  CD1 . ILE   A 1 143 ? -7.18550  22.08830  -23.85047 1.000 23.39634 ? 143 ILE   A CD1 1 
ATOM   470  N  N   . THR   A 1 144 ? -9.78303  24.05751  -28.20976 1.000 14.45407 ? 144 THR   A N   1 
ATOM   471  C  CA  . THR   A 1 144 ? -10.96022 24.55106  -28.90819 1.000 15.05964 ? 144 THR   A CA  1 
ATOM   472  C  C   . THR   A 1 144 ? -11.64479 23.42437  -29.66561 1.000 16.29576 ? 144 THR   A C   1 
ATOM   473  O  O   . THR   A 1 144 ? -12.86785 23.25884  -29.58221 1.000 14.26626 ? 144 THR   A O   1 
ATOM   474  C  CB  . THR   A 1 144 ? -10.56958 25.69782  -29.83536 1.000 19.80955 ? 144 THR   A CB  1 
ATOM   475  O  OG1 . THR   A 1 144 ? -9.98250  26.74761  -29.05032 1.000 17.35722 ? 144 THR   A OG1 1 
ATOM   476  C  CG2 . THR   A 1 144 ? -11.78684 26.23269  -30.58367 1.000 13.91649 ? 144 THR   A CG2 1 
ATOM   477  N  N   . TYR   A 1 145 ? -10.87304 22.61135  -30.38576 1.000 14.67800 ? 145 TYR   A N   1 
ATOM   478  C  CA  . TYR   A 1 145 ? -11.49810 21.48132  -31.06800 1.000 13.54298 ? 145 TYR   A CA  1 
ATOM   479  C  C   . TYR   A 1 145 ? -12.14673 20.54038  -30.06285 1.000 11.94864 ? 145 TYR   A C   1 
ATOM   480  O  O   . TYR   A 1 145 ? -13.29950 20.12953  -30.23674 1.000 13.56178 ? 145 TYR   A O   1 
ATOM   481  C  CB  . TYR   A 1 145 ? -10.48462 20.72238  -31.92966 1.000 13.20777 ? 145 TYR   A CB  1 
ATOM   482  C  CG  . TYR   A 1 145 ? -11.10687 19.46582  -32.53101 1.000 12.78421 ? 145 TYR   A CG  1 
ATOM   483  C  CD1 . TYR   A 1 145 ? -11.89579 19.53819  -33.67908 1.000 12.64410 ? 145 TYR   A CD1 1 
ATOM   484  C  CD2 . TYR   A 1 145 ? -10.94008 18.22381  -31.92946 1.000 10.91899 ? 145 TYR   A CD2 1 
ATOM   485  C  CE1 . TYR   A 1 145 ? -12.49065 18.40366  -34.22324 1.000 13.24594 ? 145 TYR   A CE1 1 
ATOM   486  C  CE2 . TYR   A 1 145 ? -11.53199 17.06744  -32.47149 1.000 11.33644 ? 145 TYR   A CE2 1 
ATOM   487  C  CZ  . TYR   A 1 145 ? -12.30002 17.16224  -33.60854 1.000 9.61108  ? 145 TYR   A CZ  1 
ATOM   488  O  OH  . TYR   A 1 145 ? -12.89551 16.03346  -34.13789 1.000 12.66572 ? 145 TYR   A OH  1 
ATOM   489  N  N   . LEU   A 1 146 ? -11.42808 20.20478  -28.98722 1.000 12.01972 ? 146 LEU   A N   1 
ATOM   490  C  CA  . LEU   A 1 146 ? -11.96403 19.23733  -28.02775 1.000 14.79209 ? 146 LEU   A CA  1 
ATOM   491  C  C   . LEU   A 1 146 ? -13.28499 19.71097  -27.43324 1.000 15.88745 ? 146 LEU   A C   1 
ATOM   492  O  O   . LEU   A 1 146 ? -14.24552 18.93691  -27.33757 1.000 14.42031 ? 146 LEU   A O   1 
ATOM   493  C  CB  . LEU   A 1 146 ? -10.94291 18.96492  -26.92689 1.000 13.97750 ? 146 LEU   A CB  1 
ATOM   494  C  CG  . LEU   A 1 146 ? -9.72030  18.18497  -27.40217 1.000 14.87768 ? 146 LEU   A CG  1 
ATOM   495  C  CD1 . LEU   A 1 146 ? -8.70479  18.14969  -26.26012 1.000 13.73229 ? 146 LEU   A CD1 1 
ATOM   496  C  CD2 . LEU   A 1 146 ? -10.08331 16.76257  -27.86095 1.000 13.63061 ? 146 LEU   A CD2 1 
ATOM   497  N  N   . MET   A 1 147 ? -13.36808 20.98823  -27.05078 1.000 16.94904 ? 147 MET   A N   1 
ATOM   498  C  CA  . MET   A 1 147 ? -14.62263 21.48997  -26.48846 1.000 18.15938 ? 147 MET   A CA  1 
ATOM   499  C  C   . MET   A 1 147 ? -15.74783 21.47450  -27.51922 1.000 16.01322 ? 147 MET   A C   1 
ATOM   500  O  O   . MET   A 1 147 ? -16.89482 21.13140  -27.19508 1.000 15.11151 ? 147 MET   A O   1 
ATOM   501  C  CB  . MET   A 1 147 ? -14.40333 22.89065  -25.91933 1.000 17.11685 ? 147 MET   A CB  1 
ATOM   502  C  CG  . MET   A 1 147 ? -13.51590 22.83369  -24.66904 1.000 21.26201 ? 147 MET   A CG  1 
ATOM   503  S  SD  . MET   A 1 147 ? -13.47201 24.37639  -23.77170 1.000 37.55606 ? 147 MET   A SD  1 
ATOM   504  C  CE  . MET   A 1 147 ? -15.19455 24.48053  -23.27239 1.000 29.86030 ? 147 MET   A CE  1 
ATOM   505  N  N   . THR   A 1 148 ? -15.44956 21.84398  -28.76557 1.000 13.71475 ? 148 THR   A N   1 
ATOM   506  C  CA  . THR   A 1 148 ? -16.47605 21.77290  -29.80300 1.000 13.97661 ? 148 THR   A CA  1 
ATOM   507  C  C   . THR   A 1 148 ? -16.90634 20.33254  -30.05572 1.000 13.60263 ? 148 THR   A C   1 
ATOM   508  O  O   . THR   A 1 148 ? -18.09997 20.04581  -30.21184 1.000 14.04533 ? 148 THR   A O   1 
ATOM   509  C  CB  . THR   A 1 148 ? -15.95700 22.39047  -31.09635 1.000 20.99641 ? 148 THR   A CB  1 
ATOM   510  O  OG1 . THR   A 1 148 ? -15.34246 23.64772  -30.80359 1.000 25.01185 ? 148 THR   A OG1 1 
ATOM   511  C  CG2 . THR   A 1 148 ? -17.10435 22.57766  -32.07757 1.000 17.31137 ? 148 THR   A CG2 1 
ATOM   512  N  N   . LEU   A 1 149 ? -15.94130 19.41745  -30.12428 1.000 12.57053 ? 149 LEU   A N   1 
ATOM   513  C  CA  . LEU   A 1 149 ? -16.27063 18.01038  -30.31689 1.000 12.64918 ? 149 LEU   A CA  1 
ATOM   514  C  C   . LEU   A 1 149 ? -17.12139 17.50038  -29.16336 1.000 14.12712 ? 149 LEU   A C   1 
ATOM   515  O  O   . LEU   A 1 149 ? -18.14516 16.83655  -29.37040 1.000 12.34299 ? 149 LEU   A O   1 
ATOM   516  C  CB  . LEU   A 1 149 ? -14.98612 17.18670  -30.43880 1.000 11.65014 ? 149 LEU   A CB  1 
ATOM   517  C  CG  . LEU   A 1 149 ? -15.19193 15.67028  -30.54857 1.000 12.90195 ? 149 LEU   A CG  1 
ATOM   518  C  CD1 . LEU   A 1 149 ? -15.69948 15.27441  -31.93656 1.000 8.51599  ? 149 LEU   A CD1 1 
ATOM   519  C  CD2 . LEU   A 1 149 ? -13.89673 14.96089  -30.21994 1.000 10.33751 ? 149 LEU   A CD2 1 
ATOM   520  N  N   . GLU   A 1 150 ? -16.71228 17.81673  -27.93537 1.000 12.66197 ? 150 GLU   A N   1 
ATOM   521  C  CA  . GLU   A 1 150 ? -17.45778 17.36910  -26.76616 1.000 12.74442 ? 150 GLU   A CA  1 
ATOM   522  C  C   . GLU   A 1 150 ? -18.88182 17.92497  -26.77188 1.000 15.08332 ? 150 GLU   A C   1 
ATOM   523  O  O   . GLU   A 1 150 ? -19.83011 17.20454  -26.44081 1.000 13.15830 ? 150 GLU   A O   1 
ATOM   524  C  CB  . GLU   A 1 150 ? -16.69861 17.75573  -25.49049 1.000 13.46621 ? 150 GLU   A CB  1 
ATOM   525  C  CG  . GLU   A 1 150 ? -17.33788 17.22689  -24.20969 1.000 15.53577 ? 150 GLU   A CG  1 
ATOM   526  C  CD  . GLU   A 1 150 ? -16.35289 16.97855  -23.07274 1.000 13.17479 ? 150 GLU   A CD  1 
ATOM   527  O  OE1 . GLU   A 1 150 ? -15.28151 17.61612  -23.02709 1.000 13.66425 ? 150 GLU   A OE1 1 
ATOM   528  O  OE2 . GLU   A 1 150 ? -16.66904 16.12964  -22.22133 1.000 14.83193 ? 150 GLU   A OE2 1 
ATOM   529  N  N   . ASP   A 1 151 ? -19.05498 19.18633  -27.20174 1.000 14.19382 ? 151 ASP   A N   1 
ATOM   530  C  CA  . ASP   A 1 151 ? -20.39271 19.78499  -27.31931 1.000 16.88551 ? 151 ASP   A CA  1 
ATOM   531  C  C   . ASP   A 1 151 ? -21.30647 18.98464  -28.23354 1.000 15.92324 ? 151 ASP   A C   1 
ATOM   532  O  O   . ASP   A 1 151 ? -22.53049 19.01442  -28.06729 1.000 14.83285 ? 151 ASP   A O   1 
ATOM   533  C  CB  . ASP   A 1 151 ? -20.31292 21.20865  -27.88569 1.000 17.23958 ? 151 ASP   A CB  1 
ATOM   534  C  CG  . ASP   A 1 151 ? -19.70581 22.20038  -26.93190 1.000 21.99752 ? 151 ASP   A CG  1 
ATOM   535  O  OD1 . ASP   A 1 151 ? -19.48755 21.85549  -25.75183 1.000 25.91305 ? 151 ASP   A OD1 1 
ATOM   536  O  OD2 . ASP   A 1 151 ? -19.43054 23.33585  -27.38557 1.000 27.60121 ? 151 ASP   A OD2 1 
ATOM   537  N  N   . HIS   A 1 152 ? -20.74704 18.32657  -29.24592 1.000 15.29843 ? 152 HIS   A N   1 
ATOM   538  C  CA  . HIS   A 1 152 ? -21.57711 17.62118  -30.21810 1.000 16.50587 ? 152 HIS   A CA  1 
ATOM   539  C  C   . HIS   A 1 152 ? -21.92447 16.18783  -29.80327 1.000 16.35626 ? 152 HIS   A C   1 
ATOM   540  O  O   . HIS   A 1 152 ? -22.58809 15.48181  -30.56845 1.000 12.19911 ? 152 HIS   A O   1 
ATOM   541  C  CB  . HIS   A 1 152 ? -20.90344 17.65325  -31.59777 1.000 15.25626 ? 152 HIS   A CB  1 
ATOM   542  C  CG  . HIS   A 1 152 ? -21.02433 18.98580  -32.27862 1.000 15.66613 ? 152 HIS   A CG  1 
ATOM   543  N  ND1 . HIS   A 1 152 ? -20.25496 20.07404  -31.92550 1.000 15.87028 ? 152 HIS   A ND1 1 
ATOM   544  C  CD2 . HIS   A 1 152 ? -21.85737 19.41713  -33.25592 1.000 17.42143 ? 152 HIS   A CD2 1 
ATOM   545  C  CE1 . HIS   A 1 152 ? -20.60299 21.11564  -32.66070 1.000 18.06370 ? 152 HIS   A CE1 1 
ATOM   546  N  NE2 . HIS   A 1 152 ? -21.56194 20.74126  -33.48491 1.000 16.19328 ? 152 HIS   A NE2 1 
ATOM   547  N  N   . TYR   A 1 153 ? -21.50814 15.74698  -28.61997 1.000 12.64548 ? 153 TYR   A N   1 
ATOM   548  C  CA  . TYR   A 1 153 ? -22.14448 14.60852  -27.96337 1.000 14.39441 ? 153 TYR   A CA  1 
ATOM   549  C  C   . TYR   A 1 153 ? -23.40667 15.10630  -27.25484 1.000 17.22169 ? 153 TYR   A C   1 
ATOM   550  O  O   . TYR   A 1 153 ? -23.46487 16.24980  -26.80143 1.000 14.81955 ? 153 TYR   A O   1 
ATOM   551  C  CB  . TYR   A 1 153 ? -21.17438 13.94297  -26.97653 1.000 12.42572 ? 153 TYR   A CB  1 
ATOM   552  C  CG  . TYR   A 1 153 ? -20.15885 13.02734  -27.65747 1.000 11.71188 ? 153 TYR   A CG  1 
ATOM   553  C  CD1 . TYR   A 1 153 ? -18.95509 13.52821  -28.16109 1.000 12.40246 ? 153 TYR   A CD1 1 
ATOM   554  C  CD2 . TYR   A 1 153 ? -20.42040 11.67065  -27.83015 1.000 10.55296 ? 153 TYR   A CD2 1 
ATOM   555  C  CE1 . TYR   A 1 153 ? -18.04264 12.69689  -28.80603 1.000 7.59062  ? 153 TYR   A CE1 1 
ATOM   556  C  CE2 . TYR   A 1 153 ? -19.49983 10.83226  -28.46819 1.000 9.04827  ? 153 TYR   A CE2 1 
ATOM   557  C  CZ  . TYR   A 1 153 ? -18.32535 11.35122  -28.95679 1.000 8.53466  ? 153 TYR   A CZ  1 
ATOM   558  O  OH  . TYR   A 1 153 ? -17.40693 10.52997  -29.59751 1.000 10.61228 ? 153 TYR   A OH  1 
ATOM   559  N  N   . HIS   A 1 154 ? -24.43531 14.26365  -27.19725 1.000 14.39688 ? 154 HIS   A N   1 
ATOM   560  C  CA  . HIS   A 1 154 ? -25.71654 14.71302  -26.65724 1.000 18.22171 ? 154 HIS   A CA  1 
ATOM   561  C  C   . HIS   A 1 154 ? -25.72213 14.55742  -25.13953 1.000 20.78308 ? 154 HIS   A C   1 
ATOM   562  O  O   . HIS   A 1 154 ? -25.63570 13.43950  -24.62100 1.000 15.36745 ? 154 HIS   A O   1 
ATOM   563  C  CB  . HIS   A 1 154 ? -26.87965 13.93637  -27.26850 1.000 16.18956 ? 154 HIS   A CB  1 
ATOM   564  C  CG  . HIS   A 1 154 ? -27.05293 14.14468  -28.74137 1.000 19.33576 ? 154 HIS   A CG  1 
ATOM   565  N  ND1 . HIS   A 1 154 ? -28.24642 13.90552  -29.38847 1.000 21.22050 ? 154 HIS   A ND1 1 
ATOM   566  C  CD2 . HIS   A 1 154 ? -26.18411 14.55614  -29.69563 1.000 16.15157 ? 154 HIS   A CD2 1 
ATOM   567  C  CE1 . HIS   A 1 154 ? -28.10460 14.15613  -30.67935 1.000 19.45950 ? 154 HIS   A CE1 1 
ATOM   568  N  NE2 . HIS   A 1 154 ? -26.86149 14.55147  -30.89208 1.000 16.93723 ? 154 HIS   A NE2 1 
ATOM   569  N  N   . ALA   A 1 155 ? -25.85017 15.67801  -24.43384 1.000 21.15312 ? 155 ALA   A N   1 
ATOM   570  C  CA  . ALA   A 1 155 ? -25.90854 15.65211  -22.97752 1.000 20.33807 ? 155 ALA   A CA  1 
ATOM   571  C  C   . ALA   A 1 155 ? -27.16427 14.95804  -22.45411 1.000 25.35521 ? 155 ALA   A C   1 
ATOM   572  O  O   . ALA   A 1 155 ? -27.18898 14.55293  -21.28901 1.000 31.49037 ? 155 ALA   A O   1 
ATOM   573  C  CB  . ALA   A 1 155 ? -25.81547 17.08281  -22.43793 1.000 23.91248 ? 155 ALA   A CB  1 
ATOM   574  N  N   . ASP   A 1 156 ? -28.18515 14.77077  -23.28911 1.000 22.58152 ? 156 ASP   A N   1 
ATOM   575  C  CA  . ASP   A 1 156 ? -29.41833 14.11592  -22.87603 1.000 25.63314 ? 156 ASP   A CA  1 
ATOM   576  C  C   . ASP   A 1 156 ? -29.49412 12.64752  -23.28949 1.000 26.11170 ? 156 ASP   A C   1 
ATOM   577  O  O   . ASP   A 1 156 ? -30.56373 12.03928  -23.18744 1.000 22.60307 ? 156 ASP   A O   1 
ATOM   578  C  CB  . ASP   A 1 156 ? -30.62764 14.87762  -23.42812 1.000 32.19884 ? 156 ASP   A CB  1 
ATOM   579  C  CG  . ASP   A 1 156 ? -30.55350 15.09763  -24.92961 1.000 36.25482 ? 156 ASP   A CG  1 
ATOM   580  O  OD1 . ASP   A 1 156 ? -29.46020 14.93550  -25.51889 1.000 29.61666 ? 156 ASP   A OD1 1 
ATOM   581  O  OD2 . ASP   A 1 156 ? -31.59535 15.46049  -25.51855 1.000 46.15587 ? 156 ASP   A OD2 1 
ATOM   582  N  N   . VAL   A 1 157 ? -28.39404 12.06408  -23.75573 1.000 17.11692 ? 157 VAL   A N   1 
ATOM   583  C  CA  . VAL   A 1 157 ? -28.34323 10.65108  -24.09382 1.000 18.18495 ? 157 VAL   A CA  1 
ATOM   584  C  C   . VAL   A 1 157 ? -27.61776 9.92894   -22.96331 1.000 16.37052 ? 157 VAL   A C   1 
ATOM   585  O  O   . VAL   A 1 157 ? -26.55213 10.37334  -22.52276 1.000 17.68095 ? 157 VAL   A O   1 
ATOM   586  C  CB  . VAL   A 1 157 ? -27.66692 10.44544  -25.46084 1.000 19.21039 ? 157 VAL   A CB  1 
ATOM   587  C  CG1 . VAL   A 1 157 ? -27.30613 9.01569   -25.67269 1.000 18.63864 ? 157 VAL   A CG1 1 
ATOM   588  C  CG2 . VAL   A 1 157 ? -28.62341 10.91782  -26.56885 1.000 15.85665 ? 157 VAL   A CG2 1 
ATOM   589  N  N   . ALA   A 1 158 ? -28.21295 8.83493   -22.46399 1.000 14.57858 ? 158 ALA   A N   1 
ATOM   590  C  CA  . ALA   A 1 158 ? -27.76677 8.25113   -21.19628 1.000 15.78952 ? 158 ALA   A CA  1 
ATOM   591  C  C   . ALA   A 1 158 ? -26.42243 7.53895   -21.31024 1.000 14.87124 ? 158 ALA   A C   1 
ATOM   592  O  O   . ALA   A 1 158 ? -25.63240 7.55521   -20.35729 1.000 11.29066 ? 158 ALA   A O   1 
ATOM   593  C  CB  . ALA   A 1 158 ? -28.80955 7.26729   -20.65784 1.000 16.88508 ? 158 ALA   A CB  1 
ATOM   594  N  N   . TYR   A 1 159 ? -26.16693 6.86406   -22.43350 1.000 13.85972 ? 159 TYR   A N   1 
ATOM   595  C  CA  . TYR   A 1 159 ? -24.94625 6.08893   -22.60669 1.000 11.31541 ? 159 TYR   A CA  1 
ATOM   596  C  C   . TYR   A 1 159 ? -24.02437 6.68475   -23.66243 1.000 13.44587 ? 159 TYR   A C   1 
ATOM   597  O  O   . TYR   A 1 159 ? -22.85904 6.97977   -23.36921 1.000 10.30296 ? 159 TYR   A O   1 
ATOM   598  C  CB  . TYR   A 1 159 ? -25.27184 4.62736   -22.96199 1.000 12.56080 ? 159 TYR   A CB  1 
ATOM   599  C  CG  . TYR   A 1 159 ? -24.01060 3.78518   -23.11554 1.000 13.33411 ? 159 TYR   A CG  1 
ATOM   600  C  CD1 . TYR   A 1 159 ? -23.29856 3.75485   -24.32600 1.000 11.19552 ? 159 TYR   A CD1 1 
ATOM   601  C  CD2 . TYR   A 1 159 ? -23.52457 3.03112   -22.04682 1.000 11.14877 ? 159 TYR   A CD2 1 
ATOM   602  C  CE1 . TYR   A 1 159 ? -22.13440 2.99472   -24.45812 1.000 11.06443 ? 159 TYR   A CE1 1 
ATOM   603  C  CE2 . TYR   A 1 159 ? -22.37820 2.25557   -22.17540 1.000 10.67650 ? 159 TYR   A CE2 1 
ATOM   604  C  CZ  . TYR   A 1 159 ? -21.68065 2.25572   -23.37841 1.000 12.24732 ? 159 TYR   A CZ  1 
ATOM   605  O  OH  . TYR   A 1 159 ? -20.53565 1.49976   -23.49581 1.000 10.45120 ? 159 TYR   A OH  1 
ATOM   606  N  N   . HIS   A 1 160 ? -24.50690 6.85151   -24.89706 1.000 12.53624 ? 160 HIS   A N   1 
ATOM   607  C  CA  . HIS   A 1 160 ? -23.65445 7.27669   -26.01233 1.000 12.15282 ? 160 HIS   A CA  1 
ATOM   608  C  C   . HIS   A 1 160 ? -23.41714 8.78992   -25.95256 1.000 13.13976 ? 160 HIS   A C   1 
ATOM   609  O  O   . HIS   A 1 160 ? -23.81606 9.56066   -26.82576 1.000 11.33340 ? 160 HIS   A O   1 
ATOM   610  C  CB  . HIS   A 1 160 ? -24.26279 6.83499   -27.34205 1.000 10.44618 ? 160 HIS   A CB  1 
ATOM   611  C  CG  . HIS   A 1 160 ? -24.20259 5.35161   -27.55130 1.000 13.26014 ? 160 HIS   A CG  1 
ATOM   612  N  ND1 . HIS   A 1 160 ? -25.27042 4.52189   -27.29273 1.000 11.72738 ? 160 HIS   A ND1 1 
ATOM   613  C  CD2 . HIS   A 1 160 ? -23.17791 4.54105   -27.91906 1.000 11.73942 ? 160 HIS   A CD2 1 
ATOM   614  C  CE1 . HIS   A 1 160 ? -24.91765 3.26841   -27.51803 1.000 12.35766 ? 160 HIS   A CE1 1 
ATOM   615  N  NE2 . HIS   A 1 160 ? -23.65461 3.25285   -27.89869 1.000 11.36725 ? 160 HIS   A NE2 1 
ATOM   616  N  N   . ASN   A 1 161 ? -22.71610 9.20571   -24.89767 1.000 12.86352 ? 161 ASN   A N   1 
ATOM   617  C  CA  . ASN   A 1 161 ? -22.46469 10.62225  -24.65131 1.000 11.34724 ? 161 ASN   A CA  1 
ATOM   618  C  C   . ASN   A 1 161 ? -20.96507 10.91678  -24.51539 1.000 14.31421 ? 161 ASN   A C   1 
ATOM   619  O  O   . ASN   A 1 161 ? -20.12322 10.05782  -24.81260 1.000 12.55865 ? 161 ASN   A O   1 
ATOM   620  C  CB  . ASN   A 1 161 ? -23.23149 11.06603  -23.40197 1.000 14.90049 ? 161 ASN   A CB  1 
ATOM   621  C  CG  . ASN   A 1 161 ? -22.91705 10.19606  -22.20096 1.000 14.20811 ? 161 ASN   A CG  1 
ATOM   622  O  OD1 . ASN   A 1 161 ? -21.74632 9.95087   -21.89174 1.000 12.02864 ? 161 ASN   A OD1 1 
ATOM   623  N  ND2 . ASN   A 1 161 ? -23.95124 9.68498   -21.54536 1.000 11.34243 ? 161 ASN   A ND2 1 
ATOM   624  N  N   . ASN   A 1 162 ? -20.61777 12.12933  -24.06109 1.000 9.38738  ? 162 ASN   A N   1 
ATOM   625  C  CA  . ASN   A 1 162 ? -19.21073 12.50531  -23.91804 1.000 11.43933 ? 162 ASN   A CA  1 
ATOM   626  C  C   . ASN   A 1 162 ? -18.47137 11.64420  -22.88874 1.000 12.55283 ? 162 ASN   A C   1 
ATOM   627  O  O   . ASN   A 1 162 ? -17.25372 11.46880  -23.00409 1.000 11.34791 ? 162 ASN   A O   1 
ATOM   628  C  CB  . ASN   A 1 162 ? -19.09651 13.98396  -23.54022 1.000 12.74204 ? 162 ASN   A CB  1 
ATOM   629  C  CG  . ASN   A 1 162 ? -19.83822 14.30826  -22.26043 1.000 16.34615 ? 162 ASN   A CG  1 
ATOM   630  O  OD1 . ASN   A 1 162 ? -20.90067 13.74546  -21.99930 1.000 16.64762 ? 162 ASN   A OD1 1 
ATOM   631  N  ND2 . ASN   A 1 162 ? -19.28324 15.21275  -21.45178 1.000 13.03830 ? 162 ASN   A ND2 1 
ATOM   632  N  N   . ILE   A 1 163 ? -19.16408 11.11280  -21.87461 1.000 10.81085 ? 163 ILE   A N   1 
ATOM   633  C  CA  . ILE   A 1 163 ? -18.47019 10.27605  -20.89451 1.000 10.84821 ? 163 ILE   A CA  1 
ATOM   634  C  C   . ILE   A 1 163 ? -18.03335 8.96067   -21.52648 1.000 10.48800 ? 163 ILE   A C   1 
ATOM   635  O  O   . ILE   A 1 163 ? -16.90648 8.49735   -21.30179 1.000 10.57885 ? 163 ILE   A O   1 
ATOM   636  C  CB  . ILE   A 1 163 ? -19.34168 10.02490  -19.65289 1.000 11.49107 ? 163 ILE   A CB  1 
ATOM   637  C  CG1 . ILE   A 1 163 ? -19.93756 11.32880  -19.12419 1.000 10.27983 ? 163 ILE   A CG1 1 
ATOM   638  C  CG2 . ILE   A 1 163 ? -18.47816 9.37183   -18.53157 1.000 8.86077  ? 163 ILE   A CG2 1 
ATOM   639  C  CD1 . ILE   A 1 163 ? -20.89498 11.07410  -17.91690 1.000 14.86423 ? 163 ILE   A CD1 1 
ATOM   640  N  N   . HIS   A 1 164 ? -18.92416 8.32948   -22.30010 1.000 8.55450  ? 164 HIS   A N   1 
ATOM   641  C  CA  . HIS   A 1 164 ? -18.54066 7.16628   -23.09795 1.000 10.33254 ? 164 HIS   A CA  1 
ATOM   642  C  C   . HIS   A 1 164 ? -17.35265 7.47679   -24.00436 1.000 13.15775 ? 164 HIS   A C   1 
ATOM   643  O  O   . HIS   A 1 164 ? -16.42620 6.66783   -24.11540 1.000 7.87020  ? 164 HIS   A O   1 
ATOM   644  C  CB  . HIS   A 1 164 ? -19.72071 6.67967   -23.93923 1.000 9.66408  ? 164 HIS   A CB  1 
ATOM   645  C  CG  . HIS   A 1 164 ? -19.36675 5.57990   -24.89755 1.000 12.03270 ? 164 HIS   A CG  1 
ATOM   646  N  ND1 . HIS   A 1 164 ? -18.87944 4.36074   -24.47729 1.000 9.08137  ? 164 HIS   A ND1 1 
ATOM   647  C  CD2 . HIS   A 1 164 ? -19.41922 5.51610   -26.25219 1.000 9.00443  ? 164 HIS   A CD2 1 
ATOM   648  C  CE1 . HIS   A 1 164 ? -18.64358 3.59240   -25.53066 1.000 12.03172 ? 164 HIS   A CE1 1 
ATOM   649  N  NE2 . HIS   A 1 164 ? -18.97383 4.26509   -26.61900 1.000 10.52359 ? 164 HIS   A NE2 1 
ATOM   650  N  N   . ALA   A 1 165 ? -17.36135 8.63362   -24.67537 1.000 9.01010  ? 165 ALA   A N   1 
ATOM   651  C  CA  . ALA   A 1 165 ? -16.25087 8.93259   -25.58434 1.000 10.61110 ? 165 ALA   A CA  1 
ATOM   652  C  C   . ALA   A 1 165 ? -14.93482 9.07978   -24.82131 1.000 11.67517 ? 165 ALA   A C   1 
ATOM   653  O  O   . ALA   A 1 165 ? -13.89173 8.57427   -25.25958 1.000 11.39840 ? 165 ALA   A O   1 
ATOM   654  C  CB  . ALA   A 1 165 ? -16.55184 10.19154  -26.39654 1.000 11.31440 ? 165 ALA   A CB  1 
ATOM   655  N  N   . ALA   A 1 166 ? -14.97487 9.75546   -23.66414 1.000 11.94039 ? 166 ALA   A N   1 
ATOM   656  C  CA  . ALA   A 1 166 ? -13.79661 9.88259   -22.81609 1.000 11.69404 ? 166 ALA   A CA  1 
ATOM   657  C  C   . ALA   A 1 166 ? -13.30036 8.52593   -22.34105 1.000 11.56114 ? 166 ALA   A C   1 
ATOM   658  O  O   . ALA   A 1 166 ? -12.08521 8.28275   -22.27724 1.000 9.25636  ? 166 ALA   A O   1 
ATOM   659  C  CB  . ALA   A 1 166 ? -14.12280 10.77504  -21.61391 1.000 9.48130  ? 166 ALA   A CB  1 
ATOM   660  N  N   . ASP   A 1 167 ? -14.23168 7.64182   -21.97754 1.000 9.85904  ? 167 ASP   A N   1 
ATOM   661  C  CA  . ASP   A 1 167 ? -13.87748 6.30523   -21.50365 1.000 12.18783 ? 167 ASP   A CA  1 
ATOM   662  C  C   . ASP   A 1 167 ? -13.19148 5.48737   -22.59684 1.000 10.80511 ? 167 ASP   A C   1 
ATOM   663  O  O   . ASP   A 1 167 ? -12.19031 4.80851   -22.33865 1.000 11.45387 ? 167 ASP   A O   1 
ATOM   664  C  CB  . ASP   A 1 167 ? -15.15059 5.61659   -20.99792 1.000 9.86106  ? 167 ASP   A CB  1 
ATOM   665  C  CG  . ASP   A 1 167 ? -14.91540 4.20367   -20.50640 1.000 11.26600 ? 167 ASP   A CG  1 
ATOM   666  O  OD1 . ASP   A 1 167 ? -13.99667 3.97738   -19.69156 1.000 10.65245 ? 167 ASP   A OD1 1 
ATOM   667  O  OD2 . ASP   A 1 167 ? -15.68987 3.31460   -20.92841 1.000 11.01092 ? 167 ASP   A OD2 1 
ATOM   668  N  N   . VAL   A 1 168 ? -13.71088 5.53632   -23.82643 1.000 9.96714  ? 168 VAL   A N   1 
ATOM   669  C  CA  . VAL   A 1 168 ? -13.09968 4.77546   -24.91893 1.000 8.67737  ? 168 VAL   A CA  1 
ATOM   670  C  C   . VAL   A 1 168 ? -11.72489 5.34553   -25.28427 1.000 10.17676 ? 168 VAL   A C   1 
ATOM   671  O  O   . VAL   A 1 168 ? -10.77638 4.58898   -25.54444 1.000 8.99025  ? 168 VAL   A O   1 
ATOM   672  C  CB  . VAL   A 1 168 ? -14.05353 4.73737   -26.12471 1.000 10.12657 ? 168 VAL   A CB  1 
ATOM   673  C  CG1 . VAL   A 1 168 ? -13.39370 4.07235   -27.33560 1.000 10.08937 ? 168 VAL   A CG1 1 
ATOM   674  C  CG2 . VAL   A 1 168 ? -15.30600 3.99171   -25.73936 1.000 7.80121  ? 168 VAL   A CG2 1 
ATOM   675  N  N   . VAL   A 1 169 ? -11.59480 6.67742   -25.31689 1.000 9.27152  ? 169 VAL   A N   1 
ATOM   676  C  CA  . VAL   A 1 169 ? -10.27570 7.30295   -25.46692 1.000 9.15063  ? 169 VAL   A CA  1 
ATOM   677  C  C   . VAL   A 1 169 ? -9.30220  6.75393   -24.43691 1.000 8.88688  ? 169 VAL   A C   1 
ATOM   678  O  O   . VAL   A 1 169 ? -8.20418  6.30905   -24.77680 1.000 11.04691 ? 169 VAL   A O   1 
ATOM   679  C  CB  . VAL   A 1 169 ? -10.36928 8.83516   -25.33675 1.000 11.95381 ? 169 VAL   A CB  1 
ATOM   680  C  CG1 . VAL   A 1 169 ? -8.96960  9.42875   -25.14785 1.000 8.06412  ? 169 VAL   A CG1 1 
ATOM   681  C  CG2 . VAL   A 1 169 ? -11.05654 9.45626   -26.54113 1.000 11.53034 ? 169 VAL   A CG2 1 
ATOM   682  N  N   . GLN   A 1 170 ? -9.67925  6.80779   -23.15143 1.000 10.51648 ? 170 GLN   A N   1 
ATOM   683  C  CA  . GLN   A 1 170 ? -8.73084  6.43698   -22.10277 1.000 11.50541 ? 170 GLN   A CA  1 
ATOM   684  C  C   . GLN   A 1 170 ? -8.42639  4.94271   -22.13747 1.000 11.03578 ? 170 GLN   A C   1 
ATOM   685  O  O   . GLN   A 1 170 ? -7.28661  4.52930   -21.88545 1.000 11.35323 ? 170 GLN   A O   1 
ATOM   686  C  CB  . GLN   A 1 170 ? -9.26348  6.86539   -20.73172 1.000 12.28407 ? 170 GLN   A CB  1 
ATOM   687  C  CG  . GLN   A 1 170 ? -8.23523  6.79534   -19.60289 1.000 13.25692 ? 170 GLN   A CG  1 
ATOM   688  C  CD  . GLN   A 1 170 ? -8.36395  5.51103   -18.78998 1.000 14.21874 ? 170 GLN   A CD  1 
ATOM   689  O  OE1 . GLN   A 1 170 ? -9.43389  4.89445   -18.74679 1.000 10.35117 ? 170 GLN   A OE1 1 
ATOM   690  N  NE2 . GLN   A 1 170 ? -7.27618  5.10428   -18.13916 1.000 9.94901  ? 170 GLN   A NE2 1 
ATOM   691  N  N   . SER   A 1 171 ? -9.42699  4.12161   -22.46732 1.000 12.08594 ? 171 SER   A N   1 
ATOM   692  C  CA  . SER   A 1 171 ? -9.21398  2.68259   -22.59196 1.000 12.08072 ? 171 SER   A CA  1 
ATOM   693  C  C   . SER   A 1 171 ? -8.29517  2.36405   -23.76333 1.000 12.84780 ? 171 SER   A C   1 
ATOM   694  O  O   . SER   A 1 171 ? -7.36801  1.55490   -23.63380 1.000 10.39611 ? 171 SER   A O   1 
ATOM   695  C  CB  . SER   A 1 171 ? -10.56303 1.97193   -22.74931 1.000 12.49497 ? 171 SER   A CB  1 
ATOM   696  O  OG  . SER   A 1 171 ? -11.35896 2.13715   -21.58667 1.000 9.44119  ? 171 SER   A OG  1 
ATOM   697  N  N   . THR   A 1 172 ? -8.53099  2.99404   -24.91441 1.000 10.40398 ? 172 THR   A N   1 
ATOM   698  C  CA  . THR   A 1 172 ? -7.60576  2.84622   -26.03501 1.000 11.01606 ? 172 THR   A CA  1 
ATOM   699  C  C   . THR   A 1 172 ? -6.19266  3.28635   -25.65736 1.000 13.72526 ? 172 THR   A C   1 
ATOM   700  O  O   . THR   A 1 172 ? -5.20864  2.64616   -26.05086 1.000 9.99454  ? 172 THR   A O   1 
ATOM   701  C  CB  . THR   A 1 172 ? -8.11958  3.65396   -27.22260 1.000 10.65312 ? 172 THR   A CB  1 
ATOM   702  O  OG1 . THR   A 1 172 ? -9.29545  3.03203   -27.73658 1.000 10.28423 ? 172 THR   A OG1 1 
ATOM   703  C  CG2 . THR   A 1 172 ? -7.06479  3.76022   -28.31484 1.000 10.59306 ? 172 THR   A CG2 1 
ATOM   704  N  N   . HIS   A 1 173 ? -6.07575  4.38247   -24.89298 1.000 11.40812 ? 173 HIS   A N   1 
ATOM   705  C  CA  . HIS   A 1 173 ? -4.76503  4.86583   -24.46051 1.000 12.37975 ? 173 HIS   A CA  1 
ATOM   706  C  C   . HIS   A 1 173 ? -4.03686  3.82447   -23.60880 1.000 14.21501 ? 173 HIS   A C   1 
ATOM   707  O  O   . HIS   A 1 173 ? -2.83131  3.60163   -23.78456 1.000 12.62821 ? 173 HIS   A O   1 
ATOM   708  C  CB  . HIS   A 1 173 ? -4.93170  6.19012   -23.69920 1.000 13.09192 ? 173 HIS   A CB  1 
ATOM   709  C  CG  . HIS   A 1 173 ? -3.75380  6.57769   -22.85146 1.000 12.66720 ? 173 HIS   A CG  1 
ATOM   710  N  ND1 . HIS   A 1 173 ? -2.53655  6.95177   -23.38115 1.000 17.27373 ? 173 HIS   A ND1 1 
ATOM   711  C  CD2 . HIS   A 1 173 ? -3.61946  6.66808   -21.50749 1.000 14.27893 ? 173 HIS   A CD2 1 
ATOM   712  C  CE1 . HIS   A 1 173 ? -1.69893  7.23657   -22.39827 1.000 15.02441 ? 173 HIS   A CE1 1 
ATOM   713  N  NE2 . HIS   A 1 173 ? -2.33574  7.08381   -21.25186 1.000 14.35909 ? 173 HIS   A NE2 1 
ATOM   714  N  N   . VAL   A 1 174 ? -4.74735  3.16986   -22.68751 1.000 10.29352 ? 174 VAL   A N   1 
ATOM   715  C  CA  . VAL   A 1 174 ? -4.13574  2.07666   -21.93209 1.000 12.98215 ? 174 VAL   A CA  1 
ATOM   716  C  C   . VAL   A 1 174 ? -3.74702  0.93020   -22.86270 1.000 15.52505 ? 174 VAL   A C   1 
ATOM   717  O  O   . VAL   A 1 174 ? -2.60956  0.44258   -22.82072 1.000 15.62231 ? 174 VAL   A O   1 
ATOM   718  C  CB  . VAL   A 1 174 ? -5.06085  1.59909   -20.80245 1.000 13.70064 ? 174 VAL   A CB  1 
ATOM   719  C  CG1 . VAL   A 1 174 ? -4.47987  0.35242   -20.13694 1.000 16.34115 ? 174 VAL   A CG1 1 
ATOM   720  C  CG2 . VAL   A 1 174 ? -5.25348  2.73228   -19.76848 1.000 16.37511 ? 174 VAL   A CG2 1 
ATOM   721  N  N   . LEU   A 1 175 ? -4.66735  0.50080   -23.73614 1.000 10.06398 ? 175 LEU   A N   1 
ATOM   722  C  CA  . LEU   A 1 175 ? -4.37532  -0.65609  -24.58569 1.000 14.41335 ? 175 LEU   A CA  1 
ATOM   723  C  C   . LEU   A 1 175 ? -3.18868  -0.39775  -25.51467 1.000 14.83270 ? 175 LEU   A C   1 
ATOM   724  O  O   . LEU   A 1 175 ? -2.44884  -1.33291  -25.84417 1.000 15.08559 ? 175 LEU   A O   1 
ATOM   725  C  CB  . LEU   A 1 175 ? -5.61759  -1.05419  -25.39065 1.000 13.05464 ? 175 LEU   A CB  1 
ATOM   726  C  CG  . LEU   A 1 175 ? -6.81013  -1.59567  -24.57239 1.000 12.52016 ? 175 LEU   A CG  1 
ATOM   727  C  CD1 . LEU   A 1 175 ? -8.02370  -1.91833  -25.44940 1.000 10.69549 ? 175 LEU   A CD1 1 
ATOM   728  C  CD2 . LEU   A 1 175 ? -6.42845  -2.82966  -23.74147 1.000 14.41225 ? 175 LEU   A CD2 1 
ATOM   729  N  N   . LEU   A 1 176 ? -2.98264  0.86143   -25.93331 1.000 12.68881 ? 176 LEU   A N   1 
ATOM   730  C  CA  . LEU   A 1 176 ? -1.83714  1.20897   -26.77579 1.000 15.63231 ? 176 LEU   A CA  1 
ATOM   731  C  C   . LEU   A 1 176 ? -0.51113  0.95891   -26.06831 1.000 15.73478 ? 176 LEU   A C   1 
ATOM   732  O  O   . LEU   A 1 176 ? 0.49972   0.66999   -26.72313 1.000 17.96531 ? 176 LEU   A O   1 
ATOM   733  C  CB  . LEU   A 1 176 ? -1.92208  2.67783   -27.19796 1.000 12.12358 ? 176 LEU   A CB  1 
ATOM   734  C  CG  . LEU   A 1 176 ? -2.83620  2.98308   -28.37629 1.000 15.16744 ? 176 LEU   A CG  1 
ATOM   735  C  CD1 . LEU   A 1 176 ? -3.13261  4.48892   -28.47034 1.000 11.03566 ? 176 LEU   A CD1 1 
ATOM   736  C  CD2 . LEU   A 1 176 ? -2.22100  2.45112   -29.69315 1.000 15.14923 ? 176 LEU   A CD2 1 
ATOM   737  N  N   . SER   A 1 177 ? -0.49916  1.05801   -24.74009 1.000 17.08325 ? 177 SER   A N   1 
ATOM   738  C  CA  . SER   A 1 177 ? 0.70963   0.95375   -23.93230 1.000 21.62456 ? 177 SER   A CA  1 
ATOM   739  C  C   . SER   A 1 177 ? 1.01282   -0.47191  -23.49324 1.000 20.16281 ? 177 SER   A C   1 
ATOM   740  O  O   . SER   A 1 177 ? 1.82999   -0.67019  -22.59210 1.000 20.16214 ? 177 SER   A O   1 
ATOM   741  C  CB  . SER   A 1 177 ? 0.58562   1.85325   -22.70249 1.000 19.67413 ? 177 SER   A CB  1 
ATOM   742  O  OG  . SER   A 1 177 ? 0.30288   3.17793   -23.10200 1.000 25.36884 ? 177 SER   A OG  1 
ATOM   743  N  N   . THR   A 1 178 ? 0.38130   -1.46538  -24.09386 1.000 15.27361 ? 178 THR   A N   1 
ATOM   744  C  CA  . THR   A 1 178 ? 0.58531   -2.82191  -23.61104 1.000 21.36871 ? 178 THR   A CA  1 
ATOM   745  C  C   . THR   A 1 178 ? 1.98867   -3.29881  -24.01274 1.000 22.65804 ? 178 THR   A C   1 
ATOM   746  O  O   . THR   A 1 178 ? 2.50110   -2.90806  -25.06848 1.000 16.41454 ? 178 THR   A O   1 
ATOM   747  C  CB  . THR   A 1 178 ? -0.53513  -3.74030  -24.14130 1.000 20.95071 ? 178 THR   A CB  1 
ATOM   748  O  OG1 . THR   A 1 178 ? -0.65395  -4.89961  -23.31577 1.000 25.80944 ? 178 THR   A OG1 1 
ATOM   749  C  CG2 . THR   A 1 178 ? -0.31123  -4.17531  -25.55837 1.000 20.36840 ? 178 THR   A CG2 1 
ATOM   750  N  N   . PRO   A 1 179 ? 2.67775   -4.05224  -23.14866 1.000 23.95284 ? 179 PRO   A N   1 
ATOM   751  C  CA  . PRO   A 1 179 ? 4.06779   -4.44012  -23.47094 1.000 21.74309 ? 179 PRO   A CA  1 
ATOM   752  C  C   . PRO   A 1 179 ? 4.22209   -5.12929  -24.82180 1.000 23.67496 ? 179 PRO   A C   1 
ATOM   753  O  O   . PRO   A 1 179 ? 5.17928   -4.84304  -25.55026 1.000 24.28260 ? 179 PRO   A O   1 
ATOM   754  C  CB  . PRO   A 1 179 ? 4.44377   -5.36900  -22.30730 1.000 24.60163 ? 179 PRO   A CB  1 
ATOM   755  C  CG  . PRO   A 1 179 ? 3.61789   -4.88056  -21.16056 1.000 28.09684 ? 179 PRO   A CG  1 
ATOM   756  C  CD  . PRO   A 1 179 ? 2.30802   -4.39129  -21.76318 1.000 24.57331 ? 179 PRO   A CD  1 
ATOM   757  N  N   . ALA   A 1 180 ? 3.28819   -6.01328  -25.19060 1.000 20.64550 ? 180 ALA   A N   1 
ATOM   758  C  CA  . ALA   A 1 180 ? 3.35944   -6.72530  -26.46523 1.000 18.22958 ? 180 ALA   A CA  1 
ATOM   759  C  C   . ALA   A 1 180 ? 3.33466   -5.80636  -27.68318 1.000 20.89715 ? 180 ALA   A C   1 
ATOM   760  O  O   . ALA   A 1 180 ? 3.63037   -6.27349  -28.79393 1.000 24.41196 ? 180 ALA   A O   1 
ATOM   761  C  CB  . ALA   A 1 180 ? 2.20982   -7.74184  -26.55638 1.000 18.06653 ? 180 ALA   A CB  1 
ATOM   762  N  N   . LEU   A 1 181 ? 2.98453   -4.52641  -27.52511 1.000 19.40343 ? 181 LEU   A N   1 
ATOM   763  C  CA  . LEU   A 1 181 ? 2.92835   -3.59660  -28.64962 1.000 19.64641 ? 181 LEU   A CA  1 
ATOM   764  C  C   . LEU   A 1 181 ? 3.96877   -2.48528  -28.55490 1.000 18.04816 ? 181 LEU   A C   1 
ATOM   765  O  O   . LEU   A 1 181 ? 3.87144   -1.49374  -29.28608 1.000 18.20303 ? 181 LEU   A O   1 
ATOM   766  C  CB  . LEU   A 1 181 ? 1.51841   -2.99383  -28.77157 1.000 18.42027 ? 181 LEU   A CB  1 
ATOM   767  C  CG  . LEU   A 1 181 ? 0.40681   -4.01493  -29.03697 1.000 20.00021 ? 181 LEU   A CG  1 
ATOM   768  C  CD1 . LEU   A 1 181 ? -1.00757  -3.36684  -28.99932 1.000 19.82995 ? 181 LEU   A CD1 1 
ATOM   769  C  CD2 . LEU   A 1 181 ? 0.64843   -4.72436  -30.35278 1.000 18.19160 ? 181 LEU   A CD2 1 
ATOM   770  N  N   . GLU   A 1 182 ? 4.96442   -2.62180  -27.68455 1.000 20.45075 ? 182 GLU   A N   1 
ATOM   771  C  CA  . GLU   A 1 182 ? 5.95024   -1.56022  -27.52317 1.000 21.83630 ? 182 GLU   A CA  1 
ATOM   772  C  C   . GLU   A 1 182 ? 6.73196   -1.35773  -28.81419 1.000 22.18148 ? 182 GLU   A C   1 
ATOM   773  O  O   . GLU   A 1 182 ? 7.14547   -2.32326  -29.46463 1.000 21.03676 ? 182 GLU   A O   1 
ATOM   774  C  CB  . GLU   A 1 182 ? 6.89073   -1.88050  -26.35978 1.000 28.17119 ? 182 GLU   A CB  1 
ATOM   775  C  CG  . GLU   A 1 182 ? 6.20260   -1.77053  -25.00386 1.000 31.12543 ? 182 GLU   A CG  1 
ATOM   776  C  CD  . GLU   A 1 182 ? 7.14878   -1.95422  -23.81575 1.000 41.87738 ? 182 GLU   A CD  1 
ATOM   777  O  OE1 . GLU   A 1 182 ? 8.39539   -1.95304  -24.00693 1.000 31.97530 ? 182 GLU   A OE1 1 
ATOM   778  O  OE2 . GLU   A 1 182 ? 6.62403   -2.09197  -22.68441 1.000 35.42431 ? 182 GLU   A OE2 1 
ATOM   779  N  N   . ALA   A 1 183 ? 6.87976   -0.08778  -29.20011 1.000 18.80301 ? 183 ALA   A N   1 
ATOM   780  C  CA  . ALA   A 1 183 ? 7.52643   0.35050   -30.43652 1.000 28.13719 ? 183 ALA   A CA  1 
ATOM   781  C  C   . ALA   A 1 183 ? 6.88291   -0.23013  -31.69866 1.000 24.58603 ? 183 ALA   A C   1 
ATOM   782  O  O   . ALA   A 1 183 ? 7.49476   -0.20074  -32.77234 1.000 30.92132 ? 183 ALA   A O   1 
ATOM   783  C  CB  . ALA   A 1 183 ? 9.02874   0.03828   -30.41727 1.000 27.56988 ? 183 ALA   A CB  1 
ATOM   784  N  N   . VAL   A 1 184 ? 5.64846   -0.73680  -31.63018 1.000 23.94431 ? 184 VAL   A N   1 
ATOM   785  C  CA  . VAL   A 1 184 ? 5.03166   -1.29180  -32.83509 1.000 20.03127 ? 184 VAL   A CA  1 
ATOM   786  C  C   . VAL   A 1 184 ? 4.44935   -0.18733  -33.70726 1.000 20.57185 ? 184 VAL   A C   1 
ATOM   787  O  O   . VAL   A 1 184 ? 4.68334   -0.14504  -34.92083 1.000 22.91332 ? 184 VAL   A O   1 
ATOM   788  C  CB  . VAL   A 1 184 ? 3.96529   -2.34492  -32.47660 1.000 18.83783 ? 184 VAL   A CB  1 
ATOM   789  C  CG1 . VAL   A 1 184 ? 3.10959   -2.66916  -33.69067 1.000 17.30300 ? 184 VAL   A CG1 1 
ATOM   790  C  CG2 . VAL   A 1 184 ? 4.61933   -3.59058  -32.02603 1.000 21.77090 ? 184 VAL   A CG2 1 
ATOM   791  N  N   . PHE   A 1 185 ? 3.68025   0.71892   -33.11407 1.000 21.61988 ? 185 PHE   A N   1 
ATOM   792  C  CA  . PHE   A 1 185 ? 2.91692   1.70172   -33.87070 1.000 18.30049 ? 185 PHE   A CA  1 
ATOM   793  C  C   . PHE   A 1 185 ? 3.63637   3.04485   -33.91396 1.000 18.34085 ? 185 PHE   A C   1 
ATOM   794  O  O   . PHE   A 1 185 ? 4.32585   3.42153   -32.96565 1.000 15.64160 ? 185 PHE   A O   1 
ATOM   795  C  CB  . PHE   A 1 185 ? 1.51846   1.86861   -33.26271 1.000 15.03112 ? 185 PHE   A CB  1 
ATOM   796  C  CG  . PHE   A 1 185 ? 0.64225   0.66043   -33.45641 1.000 13.70361 ? 185 PHE   A CG  1 
ATOM   797  C  CD1 . PHE   A 1 185 ? 0.27046   0.27305   -34.73215 1.000 17.84243 ? 185 PHE   A CD1 1 
ATOM   798  C  CD2 . PHE   A 1 185 ? 0.22278   -0.10226  -32.37356 1.000 14.05751 ? 185 PHE   A CD2 1 
ATOM   799  C  CE1 . PHE   A 1 185 ? -0.53286  -0.84709  -34.94194 1.000 14.37178 ? 185 PHE   A CE1 1 
ATOM   800  C  CE2 . PHE   A 1 185 ? -0.58442  -1.22056  -32.56044 1.000 14.72470 ? 185 PHE   A CE2 1 
ATOM   801  C  CZ  . PHE   A 1 185 ? -0.95456  -1.59848  -33.85307 1.000 14.41617 ? 185 PHE   A CZ  1 
ATOM   802  N  N   . THR   A 1 186 ? 3.46280   3.76717   -35.02604 1.000 19.11100 ? 186 THR   A N   1 
ATOM   803  C  CA  . THR   A 1 186 ? 4.06454   5.08803   -35.14793 1.000 20.49036 ? 186 THR   A CA  1 
ATOM   804  C  C   . THR   A 1 186 ? 3.26606   6.09887   -34.33980 1.000 20.46208 ? 186 THR   A C   1 
ATOM   805  O  O   . THR   A 1 186 ? 2.13104   5.83836   -33.91472 1.000 20.99679 ? 186 THR   A O   1 
ATOM   806  C  CB  . THR   A 1 186 ? 4.14783   5.55091   -36.61215 1.000 23.88428 ? 186 THR   A CB  1 
ATOM   807  O  OG1 . THR   A 1 186 ? 2.83448   5.75987   -37.14783 1.000 22.13169 ? 186 THR   A OG1 1 
ATOM   808  C  CG2 . THR   A 1 186 ? 4.89171   4.53235   -37.47707 1.000 21.75566 ? 186 THR   A CG2 1 
ATOM   809  N  N   . ASP   A 1 187 ? 3.88183   7.26380   -34.11420 1.000 18.54576 ? 187 ASP   A N   1 
ATOM   810  C  CA  . ASP   A 1 187 ? 3.14751   8.37693   -33.51931 1.000 20.58759 ? 187 ASP   A CA  1 
ATOM   811  C  C   . ASP   A 1 187 ? 1.88418   8.68571   -34.31715 1.000 18.51457 ? 187 ASP   A C   1 
ATOM   812  O  O   . ASP   A 1 187 ? 0.83918   9.00287   -33.73912 1.000 15.51630 ? 187 ASP   A O   1 
ATOM   813  C  CB  . ASP   A 1 187 ? 4.03628   9.61813   -33.43250 1.000 21.70245 ? 187 ASP   A CB  1 
ATOM   814  C  CG  . ASP   A 1 187 ? 5.28381   9.38913   -32.59558 1.000 26.18619 ? 187 ASP   A CG  1 
ATOM   815  O  OD1 . ASP   A 1 187 ? 5.21108   8.65132   -31.58748 1.000 25.24731 ? 187 ASP   A OD1 1 
ATOM   816  O  OD2 . ASP   A 1 187 ? 6.33837   9.94557   -32.96283 1.000 27.18698 ? 187 ASP   A OD2 1 
ATOM   817  N  N   . LEU   A 1 188 ? 1.95868   8.59740   -35.64669 1.000 15.45746 ? 188 LEU   A N   1 
ATOM   818  C  CA  . LEU   A 1 188 ? 0.78408   8.91832   -36.44991 1.000 17.44417 ? 188 LEU   A CA  1 
ATOM   819  C  C   . LEU   A 1 188 ? -0.32925  7.89449   -36.22656 1.000 16.39336 ? 188 LEU   A C   1 
ATOM   820  O  O   . LEU   A 1 188 ? -1.50492  8.26463   -36.12827 1.000 13.44405 ? 188 LEU   A O   1 
ATOM   821  C  CB  . LEU   A 1 188 ? 1.16273   9.02112   -37.93214 1.000 16.44128 ? 188 LEU   A CB  1 
ATOM   822  C  CG  . LEU   A 1 188 ? 0.06517   9.60705   -38.85316 1.000 14.57234 ? 188 LEU   A CG  1 
ATOM   823  C  CD1 . LEU   A 1 188 ? -0.28145  11.04660  -38.49615 1.000 13.70268 ? 188 LEU   A CD1 1 
ATOM   824  C  CD2 . LEU   A 1 188 ? 0.41607   9.48669   -40.34323 1.000 12.80161 ? 188 LEU   A CD2 1 
ATOM   825  N  N   . GLU   A 1 189 ? 0.02514   6.60697   -36.11658 1.000 16.54488 ? 189 GLU   A N   1 
ATOM   826  C  CA  . GLU   A 1 189 ? -0.97584  5.57599   -35.85913 1.000 16.13538 ? 189 GLU   A CA  1 
ATOM   827  C  C   . GLU   A 1 189 ? -1.57566  5.72629   -34.46429 1.000 15.75260 ? 189 GLU   A C   1 
ATOM   828  O  O   . GLU   A 1 189 ? -2.78821  5.56278   -34.28596 1.000 11.32964 ? 189 GLU   A O   1 
ATOM   829  C  CB  . GLU   A 1 189 ? -0.35188  4.18981   -36.04254 1.000 18.49500 ? 189 GLU   A CB  1 
ATOM   830  C  CG  . GLU   A 1 189 ? 0.03793   3.90313   -37.49936 1.000 18.65075 ? 189 GLU   A CG  1 
ATOM   831  C  CD  . GLU   A 1 189 ? 1.00723   2.74023   -37.66800 1.000 19.52648 ? 189 GLU   A CD  1 
ATOM   832  O  OE1 . GLU   A 1 189 ? 1.87304   2.53409   -36.79845 1.000 18.68228 ? 189 GLU   A OE1 1 
ATOM   833  O  OE2 . GLU   A 1 189 ? 0.89543   2.02755   -38.68493 1.000 22.36328 ? 189 GLU   A OE2 1 
ATOM   834  N  N   . ILE   A 1 190 ? -0.73877  6.03430   -33.46788 1.000 13.86368 ? 190 ILE   A N   1 
ATOM   835  C  CA  . ILE   A 1 190 ? -1.22699  6.30417   -32.11692 1.000 14.43529 ? 190 ILE   A CA  1 
ATOM   836  C  C   . ILE   A 1 190 ? -2.18586  7.48751   -32.13281 1.000 15.32071 ? 190 ILE   A C   1 
ATOM   837  O  O   . ILE   A 1 190 ? -3.26810  7.44124   -31.53641 1.000 12.86850 ? 190 ILE   A O   1 
ATOM   838  C  CB  . ILE   A 1 190 ? -0.04462  6.55598   -31.15697 1.000 15.22765 ? 190 ILE   A CB  1 
ATOM   839  C  CG1 . ILE   A 1 190 ? 0.74569   5.26030   -30.90987 1.000 13.52327 ? 190 ILE   A CG1 1 
ATOM   840  C  CG2 . ILE   A 1 190 ? -0.54595  7.15781   -29.85334 1.000 12.63380 ? 190 ILE   A CG2 1 
ATOM   841  C  CD1 . ILE   A 1 190 ? 2.13140   5.48185   -30.26446 1.000 18.44555 ? 190 ILE   A CD1 1 
ATOM   842  N  N   . LEU   A 1 191 ? -1.79283  8.57119   -32.81193 1.000 13.44415 ? 191 LEU   A N   1 
ATOM   843  C  CA  . LEU   A 1 191 ? -2.67046  9.73224   -32.93003 1.000 15.65944 ? 191 LEU   A CA  1 
ATOM   844  C  C   . LEU   A 1 191 ? -3.99047  9.34533   -33.58412 1.000 11.66386 ? 191 LEU   A C   1 
ATOM   845  O  O   . LEU   A 1 191 ? -5.06095  9.78164   -33.14774 1.000 13.86572 ? 191 LEU   A O   1 
ATOM   846  C  CB  . LEU   A 1 191 ? -1.98203  10.84577  -33.73155 1.000 15.12918 ? 191 LEU   A CB  1 
ATOM   847  C  CG  . LEU   A 1 191 ? -2.80167  12.11735  -33.99653 1.000 10.67869 ? 191 LEU   A CG  1 
ATOM   848  C  CD1 . LEU   A 1 191 ? -3.13418  12.83358  -32.67440 1.000 10.44959 ? 191 LEU   A CD1 1 
ATOM   849  C  CD2 . LEU   A 1 191 ? -2.08935  13.06881  -34.97056 1.000 13.67523 ? 191 LEU   A CD2 1 
ATOM   850  N  N   . ALA   A 1 192 ? -3.92617  8.51543   -34.62328 1.000 12.17098 ? 192 ALA   A N   1 
ATOM   851  C  CA  . ALA   A 1 192 ? -5.12976  8.07741   -35.31674 1.000 12.80946 ? 192 ALA   A CA  1 
ATOM   852  C  C   . ALA   A 1 192 ? -6.04754  7.29004   -34.38537 1.000 12.51227 ? 192 ALA   A C   1 
ATOM   853  O  O   . ALA   A 1 192 ? -7.25791  7.52598   -34.35041 1.000 12.88454 ? 192 ALA   A O   1 
ATOM   854  C  CB  . ALA   A 1 192 ? -4.74838  7.24958   -36.54535 1.000 12.30052 ? 192 ALA   A CB  1 
ATOM   855  N  N   . ALA   A 1 193 ? -5.48997  6.34957   -33.61617 1.000 10.94309 ? 193 ALA   A N   1 
ATOM   856  C  CA  . ALA   A 1 193 ? -6.32963  5.51018   -32.76279 1.000 11.15693 ? 193 ALA   A CA  1 
ATOM   857  C  C   . ALA   A 1 193 ? -7.00316  6.33492   -31.67465 1.000 13.23049 ? 193 ALA   A C   1 
ATOM   858  O  O   . ALA   A 1 193 ? -8.18152  6.12429   -31.35806 1.000 12.18523 ? 193 ALA   A O   1 
ATOM   859  C  CB  . ALA   A 1 193 ? -5.49595  4.38700   -32.13597 1.000 8.90593  ? 193 ALA   A CB  1 
ATOM   860  N  N   . ILE   A 1 194 ? -6.26203  7.27262   -31.08471 1.000 11.69874 ? 194 ILE   A N   1 
ATOM   861  C  CA  . ILE   A 1 194 ? -6.81338  8.12653   -30.03812 1.000 12.74687 ? 194 ILE   A CA  1 
ATOM   862  C  C   . ILE   A 1 194 ? -7.84578  9.09400   -30.61922 1.000 12.20479 ? 194 ILE   A C   1 
ATOM   863  O  O   . ILE   A 1 194 ? -8.94780  9.25434   -30.07646 1.000 13.68884 ? 194 ILE   A O   1 
ATOM   864  C  CB  . ILE   A 1 194 ? -5.66055  8.85198   -29.30942 1.000 10.37660 ? 194 ILE   A CB  1 
ATOM   865  C  CG1 . ILE   A 1 194 ? -4.81604  7.82733   -28.53435 1.000 12.54919 ? 194 ILE   A CG1 1 
ATOM   866  C  CG2 . ILE   A 1 194 ? -6.17027  9.91056   -28.37833 1.000 7.80799  ? 194 ILE   A CG2 1 
ATOM   867  C  CD1 . ILE   A 1 194 ? -3.51165  8.41323   -27.95888 1.000 15.53737 ? 194 ILE   A CD1 1 
ATOM   868  N  N   . PHE   A 1 195 ? -7.52230  9.73346   -31.74834 1.000 9.44109  ? 195 PHE   A N   1 
ATOM   869  C  CA  . PHE   A 1 195 ? -8.49926  10.60779  -32.38620 1.000 9.83379  ? 195 PHE   A CA  1 
ATOM   870  C  C   . PHE   A 1 195 ? -9.76939  9.84909   -32.77233 1.000 10.57248 ? 195 PHE   A C   1 
ATOM   871  O  O   . PHE   A 1 195 ? -10.87961 10.31514  -32.48659 1.000 8.90042  ? 195 PHE   A O   1 
ATOM   872  C  CB  . PHE   A 1 195 ? -7.87713  11.29756  -33.60736 1.000 9.88434  ? 195 PHE   A CB  1 
ATOM   873  C  CG  . PHE   A 1 195 ? -8.79876  12.25600  -34.29770 1.000 10.52202 ? 195 PHE   A CG  1 
ATOM   874  C  CD1 . PHE   A 1 195 ? -9.08718  13.50293  -33.73320 1.000 10.33434 ? 195 PHE   A CD1 1 
ATOM   875  C  CD2 . PHE   A 1 195 ? -9.37125  11.92423  -35.51897 1.000 10.41159 ? 195 PHE   A CD2 1 
ATOM   876  C  CE1 . PHE   A 1 195 ? -9.94239  14.39511  -34.37836 1.000 10.39085 ? 195 PHE   A CE1 1 
ATOM   877  C  CE2 . PHE   A 1 195 ? -10.22233 12.81652  -36.16856 1.000 9.21215  ? 195 PHE   A CE2 1 
ATOM   878  C  CZ  . PHE   A 1 195 ? -10.50792 14.04671  -35.59438 1.000 10.62871 ? 195 PHE   A CZ  1 
ATOM   879  N  N   . ALA   A 1 196 ? -9.63439  8.66841   -33.40223 1.000 10.24843 ? 196 ALA   A N   1 
ATOM   880  C  CA  . ALA   A 1 196 ? -10.81787 7.86956   -33.74401 1.000 8.44834  ? 196 ALA   A CA  1 
ATOM   881  C  C   . ALA   A 1 196 ? -11.66295 7.55393   -32.50961 1.000 9.28168  ? 196 ALA   A C   1 
ATOM   882  O  O   . ALA   A 1 196 ? -12.89788 7.60326   -32.56621 1.000 7.99367  ? 196 ALA   A O   1 
ATOM   883  C  CB  . ALA   A 1 196 ? -10.40936 6.56242   -34.44929 1.000 8.06860  ? 196 ALA   A CB  1 
ATOM   884  N  N   . SER   A 1 197 ? -11.02024 7.18362   -31.39982 1.000 9.63040  ? 197 SER   A N   1 
ATOM   885  C  CA  . SER   A 1 197 ? -11.76930 6.90048   -30.17296 1.000 10.69595 ? 197 SER   A CA  1 
ATOM   886  C  C   . SER   A 1 197 ? -12.56560 8.12433   -29.71387 1.000 11.07354 ? 197 SER   A C   1 
ATOM   887  O  O   . SER   A 1 197 ? -13.72167 8.00451   -29.28731 1.000 10.96214 ? 197 SER   A O   1 
ATOM   888  C  CB  . SER   A 1 197 ? -10.81120 6.44301   -29.06863 1.000 11.13326 ? 197 SER   A CB  1 
ATOM   889  O  OG  . SER   A 1 197 ? -10.13720 5.23805   -29.41719 1.000 12.16544 ? 197 SER   A OG  1 
ATOM   890  N  N   . ALA   A 1 198 ? -11.96843 9.31210   -29.81663 1.000 7.84825  ? 198 ALA   A N   1 
ATOM   891  C  CA  . ALA   A 1 198 ? -12.62520 10.53330  -29.35020 1.000 8.93732  ? 198 ALA   A CA  1 
ATOM   892  C  C   . ALA   A 1 198 ? -13.86708 10.87161  -30.17006 1.000 9.23598  ? 198 ALA   A C   1 
ATOM   893  O  O   . ALA   A 1 198 ? -14.87332 11.33625  -29.62017 1.000 7.70007  ? 198 ALA   A O   1 
ATOM   894  C  CB  . ALA   A 1 198 ? -11.63306 11.70300  -29.38808 1.000 6.91824  ? 198 ALA   A CB  1 
ATOM   895  N  N   . ILE   A 1 199 ? -13.80813 10.68677  -31.49506 1.000 9.20055  ? 199 ILE   A N   1 
ATOM   896  C  CA  . ILE   A 1 199 ? -14.92898 11.06937  -32.35054 1.000 8.01797  ? 199 ILE   A CA  1 
ATOM   897  C  C   . ILE   A 1 199 ? -15.91026 9.92945   -32.59354 1.000 9.56350  ? 199 ILE   A C   1 
ATOM   898  O  O   . ILE   A 1 199 ? -16.96029 10.15910  -33.21094 1.000 8.39715  ? 199 ILE   A O   1 
ATOM   899  C  CB  . ILE   A 1 199 ? -14.43402 11.61060  -33.71275 1.000 10.09876 ? 199 ILE   A CB  1 
ATOM   900  C  CG1 . ILE   A 1 199 ? -13.75778 10.50377  -34.53671 1.000 9.34227  ? 199 ILE   A CG1 1 
ATOM   901  C  CG2 . ILE   A 1 199 ? -13.44418 12.76043  -33.50853 1.000 9.75061  ? 199 ILE   A CG2 1 
ATOM   902  C  CD1 . ILE   A 1 199 ? -13.61034 10.87477  -36.02987 1.000 8.11144  ? 199 ILE   A CD1 1 
ATOM   903  N  N   . HIS   A 1 200 ? -15.62747 8.71757   -32.09422 1.000 10.59970 ? 200 HIS   A N   1 
ATOM   904  C  CA  . HIS   A 1 200 ? -16.21820 7.51521   -32.68993 1.000 8.66251  ? 200 HIS   A CA  1 
ATOM   905  C  C   . HIS   A 1 200 ? -17.73140 7.42079   -32.50529 1.000 10.15607 ? 200 HIS   A C   1 
ATOM   906  O  O   . HIS   A 1 200 ? -18.37594 6.70917   -33.27904 1.000 11.16037 ? 200 HIS   A O   1 
ATOM   907  C  CB  . HIS   A 1 200 ? -15.55247 6.25208   -32.13025 1.000 8.21618  ? 200 HIS   A CB  1 
ATOM   908  C  CG  . HIS   A 1 200 ? -16.19079 5.74612   -30.87906 1.000 11.93817 ? 200 HIS   A CG  1 
ATOM   909  N  ND1 . HIS   A 1 200 ? -15.85857 6.22022   -29.62509 1.000 12.09910 ? 200 HIS   A ND1 1 
ATOM   910  C  CD2 . HIS   A 1 200 ? -17.15486 4.81265   -30.68535 1.000 9.39236  ? 200 HIS   A CD2 1 
ATOM   911  C  CE1 . HIS   A 1 200 ? -16.59794 5.60273   -28.71466 1.000 9.99669  ? 200 HIS   A CE1 1 
ATOM   912  N  NE2 . HIS   A 1 200 ? -17.38659 4.74307   -29.33257 1.000 9.08042  ? 200 HIS   A NE2 1 
ATOM   913  N  N   . ASP   A 1 201 ? -18.32300 8.12401   -31.52263 1.000 11.34316 ? 201 ASP   A N   1 
ATOM   914  C  CA  . ASP   A 1 201 ? -19.77683 8.14785   -31.36110 1.000 9.64056  ? 201 ASP   A CA  1 
ATOM   915  C  C   . ASP   A 1 201 ? -20.35760 9.56526   -31.36901 1.000 11.54969 ? 201 ASP   A C   1 
ATOM   916  O  O   . ASP   A 1 201 ? -21.41777 9.77538   -30.78880 1.000 9.60102  ? 201 ASP   A O   1 
ATOM   917  C  CB  . ASP   A 1 201 ? -20.20227 7.46209   -30.05664 1.000 9.84799  ? 201 ASP   A CB  1 
ATOM   918  C  CG  . ASP   A 1 201 ? -20.36182 5.94799   -30.20177 1.000 10.53203 ? 201 ASP   A CG  1 
ATOM   919  O  OD1 . ASP   A 1 201 ? -20.64671 5.46957   -31.31749 1.000 8.71302  ? 201 ASP   A OD1 1 
ATOM   920  O  OD2 . ASP   A 1 201 ? -20.18474 5.25604   -29.18814 1.000 8.22475  ? 201 ASP   A OD2 1 
ATOM   921  N  N   . VAL   A 1 202 ? -19.69922 10.54587  -31.99787 1.000 10.88328 ? 202 VAL   A N   1 
ATOM   922  C  CA  . VAL   A 1 202 ? -20.13219 11.93001  -31.82773 1.000 9.62273  ? 202 VAL   A CA  1 
ATOM   923  C  C   . VAL   A 1 202 ? -21.48984 12.15379  -32.50393 1.000 12.13592 ? 202 VAL   A C   1 
ATOM   924  O  O   . VAL   A 1 202 ? -21.80285 11.55742  -33.54733 1.000 11.42185 ? 202 VAL   A O   1 
ATOM   925  C  CB  . VAL   A 1 202 ? -19.05529 12.90436  -32.33890 1.000 9.85990  ? 202 VAL   A CB  1 
ATOM   926  C  CG1 . VAL   A 1 202 ? -18.85097 12.75251  -33.83740 1.000 9.43568  ? 202 VAL   A CG1 1 
ATOM   927  C  CG2 . VAL   A 1 202 ? -19.42096 14.35448  -31.97588 1.000 9.22245  ? 202 VAL   A CG2 1 
ATOM   928  N  N   . ASP   A 1 203 ? -22.33136 12.98531  -31.86816 1.000 10.46962 ? 203 ASP   A N   1 
ATOM   929  C  CA  . ASP   A 1 203 ? -23.68056 13.26960  -32.35603 1.000 10.92844 ? 203 ASP   A CA  1 
ATOM   930  C  C   . ASP   A 1 203 ? -24.53027 11.99689  -32.42762 1.000 12.85247 ? 203 ASP   A C   1 
ATOM   931  O  O   . ASP   A 1 203 ? -25.41601 11.87488  -33.27676 1.000 12.22657 ? 203 ASP   A O   1 
ATOM   932  C  CB  . ASP   A 1 203 ? -23.63258 13.97543  -33.72071 1.000 12.85946 ? 203 ASP   A CB  1 
ATOM   933  C  CG  . ASP   A 1 203 ? -24.89802 14.77886  -34.02423 1.000 16.29360 ? 203 ASP   A CG  1 
ATOM   934  O  OD1 . ASP   A 1 203 ? -25.46963 15.39541  -33.08776 1.000 15.52837 ? 203 ASP   A OD1 1 
ATOM   935  O  OD2 . ASP   A 1 203 ? -25.30706 14.79052  -35.20789 1.000 14.32089 ? 203 ASP   A OD2 1 
ATOM   936  N  N   . HIS   A 1 204 ? -24.23804 11.02064  -31.57200 1.000 9.85505  ? 204 HIS   A N   1 
ATOM   937  C  CA  . HIS   A 1 204 ? -25.08796 9.84143   -31.47671 1.000 10.88756 ? 204 HIS   A CA  1 
ATOM   938  C  C   . HIS   A 1 204 ? -26.44471 10.27254  -30.92464 1.000 13.03372 ? 204 HIS   A C   1 
ATOM   939  O  O   . HIS   A 1 204 ? -26.49187 10.97723  -29.90827 1.000 12.54314 ? 204 HIS   A O   1 
ATOM   940  C  CB  . HIS   A 1 204 ? -24.43351 8.79615   -30.56901 1.000 10.56047 ? 204 HIS   A CB  1 
ATOM   941  C  CG  . HIS   A 1 204 ? -24.99325 7.41399   -30.71678 1.000 12.34260 ? 204 HIS   A CG  1 
ATOM   942  N  ND1 . HIS   A 1 204 ? -26.31075 7.10945   -30.44676 1.000 12.39782 ? 204 HIS   A ND1 1 
ATOM   943  C  CD2 . HIS   A 1 204 ? -24.40545 6.24717   -31.08077 1.000 9.84702  ? 204 HIS   A CD2 1 
ATOM   944  C  CE1 . HIS   A 1 204 ? -26.51561 5.81838   -30.65477 1.000 12.97987 ? 204 HIS   A CE1 1 
ATOM   945  N  NE2 . HIS   A 1 204 ? -25.37563 5.27138   -31.04325 1.000 10.78802 ? 204 HIS   A NE2 1 
ATOM   946  N  N   . PRO   A 1 205 ? -27.55579 9.91679   -31.56912 1.000 12.67156 ? 205 PRO   A N   1 
ATOM   947  C  CA  . PRO   A 1 205 ? -28.87651 10.34159  -31.07253 1.000 15.29397 ? 205 PRO   A CA  1 
ATOM   948  C  C   . PRO   A 1 205 ? -29.48538 9.43811   -30.01007 1.000 14.35873 ? 205 PRO   A C   1 
ATOM   949  O  O   . PRO   A 1 205 ? -30.58283 9.73542   -29.53774 1.000 17.27546 ? 205 PRO   A O   1 
ATOM   950  C  CB  . PRO   A 1 205 ? -29.73569 10.31881  -32.34562 1.000 13.42005 ? 205 PRO   A CB  1 
ATOM   951  C  CG  . PRO   A 1 205 ? -29.15116 9.16779   -33.11351 1.000 14.84486 ? 205 PRO   A CG  1 
ATOM   952  C  CD  . PRO   A 1 205 ? -27.65199 9.26367   -32.88298 1.000 12.29340 ? 205 PRO   A CD  1 
ATOM   953  N  N   . GLY   A 1 206 ? -28.81917 8.35914   -29.61568 1.000 14.70221 ? 206 GLY   A N   1 
ATOM   954  C  CA  . GLY   A 1 206 ? -29.35324 7.46235   -28.61087 1.000 16.00566 ? 206 GLY   A CA  1 
ATOM   955  C  C   . GLY   A 1 206 ? -30.21406 6.32705   -29.12363 1.000 15.62111 ? 206 GLY   A C   1 
ATOM   956  O  O   . GLY   A 1 206 ? -30.83605 5.63411   -28.30804 1.000 17.62416 ? 206 GLY   A O   1 
ATOM   957  N  N   . VAL   A 1 207 ? -30.26107 6.10195   -30.44213 1.000 14.57181 ? 207 VAL   A N   1 
ATOM   958  C  CA  . VAL   A 1 207 ? -30.99800 4.99779   -31.03930 1.000 15.12439 ? 207 VAL   A CA  1 
ATOM   959  C  C   . VAL   A 1 207 ? -30.09307 4.26387   -32.02323 1.000 14.47984 ? 207 VAL   A C   1 
ATOM   960  O  O   . VAL   A 1 207 ? -29.16693 4.84105   -32.59357 1.000 15.73932 ? 207 VAL   A O   1 
ATOM   961  C  CB  . VAL   A 1 207 ? -32.27374 5.48399   -31.75045 1.000 16.31264 ? 207 VAL   A CB  1 
ATOM   962  C  CG1 . VAL   A 1 207 ? -33.30229 5.95272   -30.72941 1.000 21.70007 ? 207 VAL   A CG1 1 
ATOM   963  C  CG2 . VAL   A 1 207 ? -31.93265 6.60944   -32.69956 1.000 16.90846 ? 207 VAL   A CG2 1 
ATOM   964  N  N   . SER   A 1 208 ? -30.39759 2.98147   -32.24586 1.000 15.00959 ? 208 SER   A N   1 
ATOM   965  C  CA  . SER   A 1 208 ? -29.56018 2.08362   -33.03893 1.000 13.70501 ? 208 SER   A CA  1 
ATOM   966  C  C   . SER   A 1 208 ? -29.68403 2.36253   -34.54215 1.000 15.38309 ? 208 SER   A C   1 
ATOM   967  O  O   . SER   A 1 208 ? -30.61886 3.01857   -35.01112 1.000 14.87233 ? 208 SER   A O   1 
ATOM   968  C  CB  . SER   A 1 208 ? -29.95496 0.63399   -32.78435 1.000 15.61067 ? 208 SER   A CB  1 
ATOM   969  O  OG  . SER   A 1 208 ? -31.25801 0.42171   -33.33331 1.000 16.63896 ? 208 SER   A OG  1 
ATOM   970  N  N   . ASN   A 1 209 ? -28.73403 1.81194   -35.30566 1.000 11.77495 ? 209 ASN   A N   1 
ATOM   971  C  CA  . ASN   A 1 209 ? -28.82518 1.85165   -36.76382 1.000 13.89777 ? 209 ASN   A CA  1 
ATOM   972  C  C   . ASN   A 1 209 ? -30.14489 1.25843   -37.25592 1.000 17.02247 ? 209 ASN   A C   1 
ATOM   973  O  O   . ASN   A 1 209 ? -30.78612 1.81044   -38.15749 1.000 15.05071 ? 209 ASN   A O   1 
ATOM   974  C  CB  . ASN   A 1 209 ? -27.64780 1.09245   -37.39131 1.000 11.02304 ? 209 ASN   A CB  1 
ATOM   975  C  CG  . ASN   A 1 209 ? -26.37639 1.93423   -37.47025 1.000 11.84313 ? 209 ASN   A CG  1 
ATOM   976  O  OD1 . ASN   A 1 209 ? -26.43224 3.16349   -37.60060 1.000 11.84960 ? 209 ASN   A OD1 1 
ATOM   977  N  ND2 . ASN   A 1 209 ? -25.22291 1.26794   -37.41089 1.000 9.82390  ? 209 ASN   A ND2 1 
ATOM   978  N  N   . GLN   A 1 210 ? -30.55477 0.11460   -36.68964 1.000 13.33474 ? 210 GLN   A N   1 
ATOM   979  C  CA  . GLN   A 1 210 ? -31.78001 -0.53208  -37.15831 1.000 15.89346 ? 210 GLN   A CA  1 
ATOM   980  C  C   . GLN   A 1 210 ? -32.99382 0.36349   -36.93810 1.000 18.35952 ? 210 GLN   A C   1 
ATOM   981  O  O   . GLN   A 1 210 ? -33.88188 0.44653   -37.79985 1.000 20.70404 ? 210 GLN   A O   1 
ATOM   982  C  CB  . GLN   A 1 210 ? -31.97333 -1.88176  -36.46209 1.000 18.98275 ? 210 GLN   A CB  1 
ATOM   983  C  CG  . GLN   A 1 210 ? -33.05312 -2.75540  -37.11218 1.000 23.71461 ? 210 GLN   A CG  1 
ATOM   984  C  CD  . GLN   A 1 210 ? -32.70616 -3.13732  -38.54111 1.000 23.01440 ? 210 GLN   A CD  1 
ATOM   985  O  OE1 . GLN   A 1 210 ? -31.78502 -3.90991  -38.77388 1.000 32.16798 ? 210 GLN   A OE1 1 
ATOM   986  N  NE2 . GLN   A 1 210 ? -33.43602 -2.59093  -39.50046 1.000 24.53822 ? 210 GLN   A NE2 1 
ATOM   987  N  N   . PHE   A 1 211 ? -33.04816 1.04181   -35.78928 1.000 16.65458 ? 211 PHE   A N   1 
ATOM   988  C  CA  . PHE   A 1 211 ? -34.12429 1.98903   -35.53194 1.000 22.01779 ? 211 PHE   A CA  1 
ATOM   989  C  C   . PHE   A 1 211 ? -34.13808 3.08758   -36.58331 1.000 20.10151 ? 211 PHE   A C   1 
ATOM   990  O  O   . PHE   A 1 211 ? -35.19497 3.44390   -37.11748 1.000 18.69151 ? 211 PHE   A O   1 
ATOM   991  C  CB  . PHE   A 1 211 ? -33.97337 2.58953   -34.12732 1.000 18.73703 ? 211 PHE   A CB  1 
ATOM   992  C  CG  . PHE   A 1 211 ? -35.04042 3.59936   -33.77777 1.000 21.06889 ? 211 PHE   A CG  1 
ATOM   993  C  CD1 . PHE   A 1 211 ? -34.85666 4.95084   -34.04784 1.000 18.85564 ? 211 PHE   A CD1 1 
ATOM   994  C  CD2 . PHE   A 1 211 ? -36.22843 3.19666   -33.18092 1.000 22.22182 ? 211 PHE   A CD2 1 
ATOM   995  C  CE1 . PHE   A 1 211 ? -35.83323 5.87597   -33.73615 1.000 24.32827 ? 211 PHE   A CE1 1 
ATOM   996  C  CE2 . PHE   A 1 211 ? -37.20346 4.12207   -32.86144 1.000 25.17259 ? 211 PHE   A CE2 1 
ATOM   997  C  CZ  . PHE   A 1 211 ? -36.99928 5.46280   -33.13506 1.000 26.66555 ? 211 PHE   A CZ  1 
ATOM   998  N  N   . LEU   A 1 212 ? -32.96570 3.64800   -36.88337 1.000 16.52382 ? 212 LEU   A N   1 
ATOM   999  C  CA  . LEU   A 1 212 ? -32.89890 4.70994   -37.87673 1.000 17.11901 ? 212 LEU   A CA  1 
ATOM   1000 C  C   . LEU   A 1 212 ? -33.28391 4.20501   -39.26314 1.000 16.97866 ? 212 LEU   A C   1 
ATOM   1001 O  O   . LEU   A 1 212 ? -33.85412 4.96314   -40.05311 1.000 19.95745 ? 212 LEU   A O   1 
ATOM   1002 C  CB  . LEU   A 1 212 ? -31.49336 5.32223   -37.89237 1.000 14.80678 ? 212 LEU   A CB  1 
ATOM   1003 C  CG  . LEU   A 1 212 ? -31.00063 6.03443   -36.64087 1.000 15.77473 ? 212 LEU   A CG  1 
ATOM   1004 C  CD1 . LEU   A 1 212 ? -29.49757 6.31879   -36.77343 1.000 14.74532 ? 212 LEU   A CD1 1 
ATOM   1005 C  CD2 . LEU   A 1 212 ? -31.76166 7.33739   -36.41080 1.000 13.55483 ? 212 LEU   A CD2 1 
ATOM   1006 N  N   . ILE   A 1 213 ? -32.96232 2.94400   -39.58747 1.000 16.81900 ? 213 ILE   A N   1 
ATOM   1007 C  CA  . ILE   A 1 213 ? -33.40847 2.35655   -40.85486 1.000 15.94927 ? 213 ILE   A CA  1 
ATOM   1008 C  C   . ILE   A 1 213 ? -34.92578 2.18649   -40.85434 1.000 22.31435 ? 213 ILE   A C   1 
ATOM   1009 O  O   . ILE   A 1 213 ? -35.61377 2.54119   -41.82134 1.000 18.19109 ? 213 ILE   A O   1 
ATOM   1010 C  CB  . ILE   A 1 213 ? -32.70417 1.00901   -41.10079 1.000 18.39200 ? 213 ILE   A CB  1 
ATOM   1011 C  CG1 . ILE   A 1 213 ? -31.20173 1.21773   -41.33173 1.000 14.53615 ? 213 ILE   A CG1 1 
ATOM   1012 C  CG2 . ILE   A 1 213 ? -33.40796 0.21466   -42.26300 1.000 18.01814 ? 213 ILE   A CG2 1 
ATOM   1013 C  CD1 . ILE   A 1 213 ? -30.38142 -0.06254  -41.27851 1.000 18.21770 ? 213 ILE   A CD1 1 
ATOM   1014 N  N   . ASN   A 1 214 ? -35.46504 1.65427   -39.75366 1.000 22.77270 ? 214 ASN   A N   1 
ATOM   1015 C  CA  . ASN   A 1 214 ? -36.87593 1.27466   -39.69067 1.000 26.23632 ? 214 ASN   A CA  1 
ATOM   1016 C  C   . ASN   A 1 214 ? -37.79835 2.48115   -39.66965 1.000 25.25190 ? 214 ASN   A C   1 
ATOM   1017 O  O   . ASN   A 1 214 ? -38.95700 2.37798   -40.08380 1.000 30.52292 ? 214 ASN   A O   1 
ATOM   1018 C  CB  . ASN   A 1 214 ? -37.13802 0.41534   -38.45370 1.000 21.92961 ? 214 ASN   A CB  1 
ATOM   1019 C  CG  . ASN   A 1 214 ? -36.56366 -0.96674  -38.58011 1.000 25.71252 ? 214 ASN   A CG  1 
ATOM   1020 O  OD1 . ASN   A 1 214 ? -36.19028 -1.39790  -39.67547 1.000 31.38169 ? 214 ASN   A OD1 1 
ATOM   1021 N  ND2 . ASN   A 1 214 ? -36.48799 -1.68313  -37.45741 1.000 28.65912 ? 214 ASN   A ND2 1 
ATOM   1022 N  N   . THR   A 1 215 ? -37.31985 3.62007   -39.18934 1.000 21.18119 ? 215 THR   A N   1 
ATOM   1023 C  CA  . THR   A 1 215 ? -38.12800 4.82592   -39.10009 1.000 24.58923 ? 215 THR   A CA  1 
ATOM   1024 C  C   . THR   A 1 215 ? -37.90211 5.78009   -40.27128 1.000 23.64734 ? 215 THR   A C   1 
ATOM   1025 O  O   . THR   A 1 215 ? -38.37097 6.92138   -40.22281 1.000 23.67664 ? 215 THR   A O   1 
ATOM   1026 C  CB  . THR   A 1 215 ? -37.84288 5.54145   -37.78065 1.000 24.88199 ? 215 THR   A CB  1 
ATOM   1027 O  OG1 . THR   A 1 215 ? -36.44517 5.85658   -37.70663 1.000 21.88923 ? 215 THR   A OG1 1 
ATOM   1028 C  CG2 . THR   A 1 215 ? -38.22365 4.64683   -36.59719 1.000 26.43076 ? 215 THR   A CG2 1 
ATOM   1029 N  N   . ASN   A 1 216 ? -37.19666 5.33535   -41.31189 1.000 25.38839 ? 216 ASN   A N   1 
ATOM   1030 C  CA  . ASN   A 1 216 ? -36.89665 6.15176   -42.49173 1.000 26.67353 ? 216 ASN   A CA  1 
ATOM   1031 C  C   . ASN   A 1 216 ? -36.31390 7.50882   -42.09919 1.000 21.74006 ? 216 ASN   A C   1 
ATOM   1032 O  O   . ASN   A 1 216 ? -36.76166 8.56444   -42.54807 1.000 24.87489 ? 216 ASN   A O   1 
ATOM   1033 C  CB  . ASN   A 1 216 ? -38.14274 6.31191   -43.36302 1.000 27.78362 ? 216 ASN   A CB  1 
ATOM   1034 C  CG  . ASN   A 1 216 ? -38.89137 5.00195   -43.54697 1.000 34.37023 ? 216 ASN   A CG  1 
ATOM   1035 O  OD1 . ASN   A 1 216 ? -38.29514 3.95786   -43.84281 1.000 30.82911 ? 216 ASN   A OD1 1 
ATOM   1036 N  ND2 . ASN   A 1 216 ? -40.20683 5.04549   -43.35206 1.000 39.69801 ? 216 ASN   A ND2 1 
ATOM   1037 N  N   . SER   A 1 217 ? -35.30254 7.47441   -41.23646 1.000 21.52483 ? 217 SER   A N   1 
ATOM   1038 C  CA  . SER   A 1 217 ? -34.67216 8.70372   -40.78029 1.000 18.12498 ? 217 SER   A CA  1 
ATOM   1039 C  C   . SER   A 1 217 ? -33.91160 9.37474   -41.91896 1.000 18.87781 ? 217 SER   A C   1 
ATOM   1040 O  O   . SER   A 1 217 ? -33.57644 8.75666   -42.92824 1.000 19.52000 ? 217 SER   A O   1 
ATOM   1041 C  CB  . SER   A 1 217 ? -33.72237 8.41582   -39.62216 1.000 17.67364 ? 217 SER   A CB  1 
ATOM   1042 O  OG  . SER   A 1 217 ? -32.74078 7.47752   -40.02474 1.000 14.63566 ? 217 SER   A OG  1 
ATOM   1043 N  N   . GLU   A 1 218 ? -33.64465 10.66757  -41.74199 1.000 16.86886 ? 218 GLU   A N   1 
ATOM   1044 C  CA  . GLU   A 1 218 ? -32.74175 11.36627  -42.64615 1.000 21.36682 ? 218 GLU   A CA  1 
ATOM   1045 C  C   . GLU   A 1 218 ? -31.35961 10.70668  -42.67837 1.000 17.82908 ? 218 GLU   A C   1 
ATOM   1046 O  O   . GLU   A 1 218 ? -30.75666 10.57180  -43.75046 1.000 15.77484 ? 218 GLU   A O   1 
ATOM   1047 C  CB  . GLU   A 1 218 ? -32.64115 12.83549  -42.22397 1.000 25.67860 ? 218 GLU   A CB  1 
ATOM   1048 C  CG  . GLU   A 1 218 ? -32.59319 13.80467  -43.37362 1.000 37.09102 ? 218 GLU   A CG  1 
ATOM   1049 C  CD  . GLU   A 1 218 ? -33.73212 13.58498  -44.35942 1.000 44.08524 ? 218 GLU   A CD  1 
ATOM   1050 O  OE1 . GLU   A 1 218 ? -34.86957 13.30703  -43.91003 1.000 46.44478 ? 218 GLU   A OE1 1 
ATOM   1051 O  OE2 . GLU   A 1 218 ? -33.48747 13.68185  -45.58378 1.000 42.86679 ? 218 GLU   A OE2 1 
ATOM   1052 N  N   . LEU   A 1 219 ? -30.84157 10.28639  -41.51567 1.000 17.63553 ? 219 LEU   A N   1 
ATOM   1053 C  CA  . LEU   A 1 219 ? -29.50976 9.68180   -41.47420 1.000 15.70899 ? 219 LEU   A CA  1 
ATOM   1054 C  C   . LEU   A 1 219 ? -29.44631 8.42347   -42.32861 1.000 15.17390 ? 219 LEU   A C   1 
ATOM   1055 O  O   . LEU   A 1 219 ? -28.49108 8.22811   -43.08659 1.000 12.27806 ? 219 LEU   A O   1 
ATOM   1056 C  CB  . LEU   A 1 219 ? -29.10360 9.35643   -40.03375 1.000 14.24321 ? 219 LEU   A CB  1 
ATOM   1057 C  CG  . LEU   A 1 219 ? -28.42485 10.51468  -39.29385 1.000 20.68077 ? 219 LEU   A CG  1 
ATOM   1058 C  CD1 . LEU   A 1 219 ? -28.32317 10.21870  -37.80439 1.000 19.65024 ? 219 LEU   A CD1 1 
ATOM   1059 C  CD2 . LEU   A 1 219 ? -27.04605 10.84548  -39.89068 1.000 18.26184 ? 219 LEU   A CD2 1 
ATOM   1060 N  N   . ALA   A 1 220 ? -30.44744 7.54494   -42.19576 1.000 12.78019 ? 220 ALA   A N   1 
ATOM   1061 C  CA  . ALA   A 1 220 ? -30.42803 6.28707   -42.93347 1.000 15.97626 ? 220 ALA   A CA  1 
ATOM   1062 C  C   . ALA   A 1 220 ? -30.61462 6.52860   -44.42286 1.000 15.93289 ? 220 ALA   A C   1 
ATOM   1063 O  O   . ALA   A 1 220 ? -30.02116 5.82972   -45.25561 1.000 11.88433 ? 220 ALA   A O   1 
ATOM   1064 C  CB  . ALA   A 1 220 ? -31.51492 5.34430   -42.41017 1.000 12.06998 ? 220 ALA   A CB  1 
ATOM   1065 N  N   . LEU   A 1 221 ? -31.44849 7.50278   -44.76677 1.000 13.33054 ? 221 LEU   A N   1 
ATOM   1066 C  CA  . LEU   A 1 221 ? -31.58256 7.91847   -46.15634 1.000 15.70279 ? 221 LEU   A CA  1 
ATOM   1067 C  C   . LEU   A 1 221 ? -30.25930 8.44565   -46.70421 1.000 15.26889 ? 221 LEU   A C   1 
ATOM   1068 O  O   . LEU   A 1 221 ? -29.89546 8.15362   -47.85063 1.000 15.11939 ? 221 LEU   A O   1 
ATOM   1069 C  CB  . LEU   A 1 221 ? -32.67761 8.98116   -46.26069 1.000 14.46983 ? 221 LEU   A CB  1 
ATOM   1070 C  CG  . LEU   A 1 221 ? -33.18424 9.30051   -47.66193 1.000 24.16881 ? 221 LEU   A CG  1 
ATOM   1071 C  CD1 . LEU   A 1 221 ? -33.96009 8.09462   -48.21343 1.000 24.96731 ? 221 LEU   A CD1 1 
ATOM   1072 C  CD2 . LEU   A 1 221 ? -34.07637 10.52601  -47.61661 1.000 31.88006 ? 221 LEU   A CD2 1 
ATOM   1073 N  N   . MET   A 1 222 ? -29.52452 9.22227   -45.90681 1.000 12.00114 ? 222 MET   A N   1 
ATOM   1074 C  CA  . MET   A 1 222 ? -28.26725 9.78865   -46.40857 1.000 14.83955 ? 222 MET   A CA  1 
ATOM   1075 C  C   . MET   A 1 222 ? -27.22697 8.69904   -46.65897 1.000 14.21024 ? 222 MET   A C   1 
ATOM   1076 O  O   . MET   A 1 222 ? -26.46506 8.75873   -47.63722 1.000 13.56016 ? 222 MET   A O   1 
ATOM   1077 C  CB  . MET   A 1 222 ? -27.72273 10.82598  -45.42256 1.000 14.05642 ? 222 MET   A CB  1 
ATOM   1078 C  CG  . MET   A 1 222 ? -26.38999 11.46302  -45.85384 1.000 16.40166 ? 222 MET   A CG  1 
ATOM   1079 S  SD  . MET   A 1 222 ? -26.59831 12.81128  -47.05683 1.000 21.38862 ? 222 MET   A SD  1 
ATOM   1080 C  CE  . MET   A 1 222 ? -27.22044 14.10410  -45.97863 1.000 18.01519 ? 222 MET   A CE  1 
ATOM   1081 N  N   . TYR   A 1 223 ? -27.19645 7.68412   -45.79802 1.000 13.17076 ? 223 TYR   A N   1 
ATOM   1082 C  CA  . TYR   A 1 223 ? -26.12420 6.70426   -45.79690 1.000 13.13806 ? 223 TYR   A CA  1 
ATOM   1083 C  C   . TYR   A 1 223 ? -26.55032 5.33616   -46.31924 1.000 13.32401 ? 223 TYR   A C   1 
ATOM   1084 O  O   . TYR   A 1 223 ? -25.81179 4.36339   -46.13857 1.000 11.96244 ? 223 TYR   A O   1 
ATOM   1085 C  CB  . TYR   A 1 223 ? -25.53867 6.61636   -44.38057 1.000 12.77070 ? 223 TYR   A CB  1 
ATOM   1086 C  CG  . TYR   A 1 223 ? -24.70180 7.84564   -44.06127 1.000 11.66283 ? 223 TYR   A CG  1 
ATOM   1087 C  CD1 . TYR   A 1 223 ? -23.59868 8.15940   -44.83974 1.000 12.02794 ? 223 TYR   A CD1 1 
ATOM   1088 C  CD2 . TYR   A 1 223 ? -24.99705 8.67772   -42.98063 1.000 12.36088 ? 223 TYR   A CD2 1 
ATOM   1089 C  CE1 . TYR   A 1 223 ? -22.80886 9.27700   -44.56796 1.000 11.43092 ? 223 TYR   A CE1 1 
ATOM   1090 C  CE2 . TYR   A 1 223 ? -24.21010 9.81608   -42.69518 1.000 12.75061 ? 223 TYR   A CE2 1 
ATOM   1091 C  CZ  . TYR   A 1 223 ? -23.11680 10.10350  -43.50109 1.000 11.82595 ? 223 TYR   A CZ  1 
ATOM   1092 O  OH  . TYR   A 1 223 ? -22.31887 11.20924  -43.26446 1.000 12.42781 ? 223 TYR   A OH  1 
ATOM   1093 N  N   . ASN   A 1 224 ? -27.72515 5.23462   -46.95803 1.000 10.25768 ? 224 ASN   A N   1 
ATOM   1094 C  CA  . ASN   A 1 224 ? -28.12888 4.01558   -47.66227 1.000 11.14106 ? 224 ASN   A CA  1 
ATOM   1095 C  C   . ASN   A 1 224 ? -28.08431 2.78045   -46.76025 1.000 11.96174 ? 224 ASN   A C   1 
ATOM   1096 O  O   . ASN   A 1 224 ? -27.68868 1.68938   -47.17788 1.000 11.18975 ? 224 ASN   A O   1 
ATOM   1097 C  CB  . ASN   A 1 224 ? -27.27612 3.83590   -48.91869 1.000 14.03172 ? 224 ASN   A CB  1 
ATOM   1098 C  CG  . ASN   A 1 224 ? -27.41560 5.02434   -49.85065 1.000 12.31677 ? 224 ASN   A CG  1 
ATOM   1099 O  OD1 . ASN   A 1 224 ? -28.53160 5.37696   -50.22766 1.000 15.24356 ? 224 ASN   A OD1 1 
ATOM   1100 N  ND2 . ASN   A 1 224 ? -26.30955 5.68905   -50.16369 1.000 12.48519 ? 224 ASN   A ND2 1 
ATOM   1101 N  N   . ASP   A 1 225 ? -28.51587 2.96151   -45.51309 1.000 13.00777 ? 225 ASP   A N   1 
ATOM   1102 C  CA  . ASP   A 1 225 ? -28.70632 1.92191   -44.49762 1.000 12.02942 ? 225 ASP   A CA  1 
ATOM   1103 C  C   . ASP   A 1 225 ? -27.42584 1.20954   -44.06045 1.000 11.92846 ? 225 ASP   A C   1 
ATOM   1104 O  O   . ASP   A 1 225 ? -27.50988 0.23094   -43.31160 1.000 11.76727 ? 225 ASP   A O   1 
ATOM   1105 C  CB  . ASP   A 1 225 ? -29.73002 0.86828   -44.95170 1.000 11.99111 ? 225 ASP   A CB  1 
ATOM   1106 C  CG  . ASP   A 1 225 ? -31.09648 1.47334   -45.22970 1.000 15.49718 ? 225 ASP   A CG  1 
ATOM   1107 O  OD1 . ASP   A 1 225 ? -31.35744 2.59920   -44.73673 1.000 10.86047 ? 225 ASP   A OD1 1 
ATOM   1108 O  OD2 . ASP   A 1 225 ? -31.90667 0.82310   -45.92841 1.000 14.40641 ? 225 ASP   A OD2 1 
ATOM   1109 N  N   . SER   A 1 226 ? -26.24137 1.67114   -44.46164 1.000 13.92487 ? 226 SER   A N   1 
ATOM   1110 C  CA  . SER   A 1 226 ? -24.99521 0.93786   -44.21480 1.000 11.34708 ? 226 SER   A CA  1 
ATOM   1111 C  C   . SER   A 1 226 ? -24.10815 1.69232   -43.22796 1.000 12.50144 ? 226 SER   A C   1 
ATOM   1112 O  O   . SER   A 1 226 ? -23.62361 2.78712   -43.53786 1.000 13.36485 ? 226 SER   A O   1 
ATOM   1113 C  CB  . SER   A 1 226 ? -24.24872 0.71377   -45.53230 1.000 15.79053 ? 226 SER   A CB  1 
ATOM   1114 O  OG  . SER   A 1 226 ? -25.11404 0.11748   -46.48993 1.000 26.37593 ? 226 SER   A OG  1 
ATOM   1115 N  N   . SER   A 1 227 ? -23.86828 1.09765   -42.05878 1.000 14.12123 ? 227 SER   A N   1 
ATOM   1116 C  CA  . SER   A 1 227 ? -23.10534 1.75453   -40.98873 1.000 12.09672 ? 227 SER   A CA  1 
ATOM   1117 C  C   . SER   A 1 227 ? -23.52275 3.22020   -40.83520 1.000 10.98831 ? 227 SER   A C   1 
ATOM   1118 O  O   . SER   A 1 227 ? -22.69168 4.13424   -40.86297 1.000 10.48754 ? 227 SER   A O   1 
ATOM   1119 C  CB  . SER   A 1 227 ? -21.59614 1.63223   -41.24096 1.000 11.83560 ? 227 SER   A CB  1 
ATOM   1120 O  OG  . SER   A 1 227 ? -21.19938 0.26768   -41.25937 1.000 12.53704 ? 227 SER   A OG  1 
ATOM   1121 N  N   . VAL   A 1 228 ? -24.84308 3.43362   -40.68729 1.000 11.52614 ? 228 VAL   A N   1 
ATOM   1122 C  CA  . VAL   A 1 228 ? -25.42083 4.77665   -40.75840 1.000 10.18908 ? 228 VAL   A CA  1 
ATOM   1123 C  C   . VAL   A 1 228 ? -24.80803 5.69083   -39.70083 1.000 12.28136 ? 228 VAL   A C   1 
ATOM   1124 O  O   . VAL   A 1 228 ? -24.32779 6.78685   -40.00626 1.000 13.04985 ? 228 VAL   A O   1 
ATOM   1125 C  CB  . VAL   A 1 228 ? -26.95660 4.71495   -40.61550 1.000 10.83673 ? 228 VAL   A CB  1 
ATOM   1126 C  CG1 . VAL   A 1 228 ? -27.51234 6.11274   -40.37917 1.000 9.94422  ? 228 VAL   A CG1 1 
ATOM   1127 C  CG2 . VAL   A 1 228 ? -27.60697 4.10451   -41.87524 1.000 10.90746 ? 228 VAL   A CG2 1 
ATOM   1128 N  N   . LEU   A 1 229 ? -24.87272 5.27719   -38.43211 1.000 12.29076 ? 229 LEU   A N   1 
ATOM   1129 C  CA  . LEU   A 1 229 ? -24.29873 6.07967   -37.35456 1.000 13.36004 ? 229 LEU   A CA  1 
ATOM   1130 C  C   . LEU   A 1 229 ? -22.79879 6.29071   -37.54161 1.000 10.71109 ? 229 LEU   A C   1 
ATOM   1131 O  O   . LEU   A 1 229 ? -22.29213 7.40893   -37.37459 1.000 10.15644 ? 229 LEU   A O   1 
ATOM   1132 C  CB  . LEU   A 1 229 ? -24.57129 5.40704   -36.00627 1.000 12.64787 ? 229 LEU   A CB  1 
ATOM   1133 C  CG  . LEU   A 1 229 ? -26.01515 5.47536   -35.49226 1.000 14.44698 ? 229 LEU   A CG  1 
ATOM   1134 C  CD1 . LEU   A 1 229 ? -26.32055 4.39120   -34.44916 1.000 13.90304 ? 229 LEU   A CD1 1 
ATOM   1135 C  CD2 . LEU   A 1 229 ? -26.29069 6.85139   -34.92155 1.000 13.23349 ? 229 LEU   A CD2 1 
ATOM   1136 N  N   . GLU   A 1 230 ? -22.07232 5.22756   -37.87958 1.000 11.39534 ? 230 GLU   A N   1 
ATOM   1137 C  CA  . GLU   A 1 230 ? -20.61491 5.30939   -37.86556 1.000 9.73630  ? 230 GLU   A CA  1 
ATOM   1138 C  C   . GLU   A 1 230 ? -20.10396 6.23383   -38.96611 1.000 12.20836 ? 230 GLU   A C   1 
ATOM   1139 O  O   . GLU   A 1 230 ? -19.11993 6.96826   -38.76761 1.000 9.91341  ? 230 GLU   A O   1 
ATOM   1140 C  CB  . GLU   A 1 230 ? -20.01757 3.89895   -37.98067 1.000 9.69057  ? 230 GLU   A CB  1 
ATOM   1141 C  CG  . GLU   A 1 230 ? -20.26948 2.98283   -36.74246 1.000 10.13841 ? 230 GLU   A CG  1 
ATOM   1142 C  CD  . GLU   A 1 230 ? -21.73234 2.49816   -36.61256 1.000 13.50551 ? 230 GLU   A CD  1 
ATOM   1143 O  OE1 . GLU   A 1 230 ? -22.43467 2.42318   -37.65709 1.000 9.59337  ? 230 GLU   A OE1 1 
ATOM   1144 O  OE2 . GLU   A 1 230 ? -22.16890 2.18797   -35.46678 1.000 11.57838 ? 230 GLU   A OE2 1 
ATOM   1145 N  N   . ASN   A 1 231 ? -20.76002 6.21829   -40.13378 1.000 9.43988  ? 231 ASN   A N   1 
ATOM   1146 C  CA  . ASN   A 1 231 ? -20.43038 7.19813   -41.16450 1.000 10.67299 ? 231 ASN   A CA  1 
ATOM   1147 C  C   . ASN   A 1 231 ? -20.68306 8.60773   -40.66239 1.000 12.09913 ? 231 ASN   A C   1 
ATOM   1148 O  O   . ASN   A 1 231 ? -19.89136 9.52859   -40.91403 1.000 8.45041  ? 231 ASN   A O   1 
ATOM   1149 C  CB  . ASN   A 1 231 ? -21.24109 6.93221   -42.43474 1.000 9.97902  ? 231 ASN   A CB  1 
ATOM   1150 C  CG  . ASN   A 1 231 ? -20.57795 5.91841   -43.31613 1.000 14.50986 ? 231 ASN   A CG  1 
ATOM   1151 O  OD1 . ASN   A 1 231 ? -19.52177 6.19380   -43.89851 1.000 12.29879 ? 231 ASN   A OD1 1 
ATOM   1152 N  ND2 . ASN   A 1 231 ? -21.16826 4.72348   -43.40620 1.000 10.42537 ? 231 ASN   A ND2 1 
ATOM   1153 N  N   . HIS   A 1 232 ? -21.78701 8.78732   -39.94941 1.000 10.36986 ? 232 HIS   A N   1 
ATOM   1154 C  CA  . HIS   A 1 232 ? -22.13972 10.10508  -39.45023 1.000 11.49372 ? 232 HIS   A CA  1 
ATOM   1155 C  C   . HIS   A 1 232 ? -21.14240 10.58266  -38.40444 1.000 10.19314 ? 232 HIS   A C   1 
ATOM   1156 O  O   . HIS   A 1 232 ? -20.74006 11.74694  -38.43131 1.000 9.93622  ? 232 HIS   A O   1 
ATOM   1157 C  CB  . HIS   A 1 232 ? -23.56047 10.08394  -38.87392 1.000 10.30890 ? 232 HIS   A CB  1 
ATOM   1158 C  CG  . HIS   A 1 232 ? -24.01219 11.41495  -38.36075 1.000 12.36882 ? 232 HIS   A CG  1 
ATOM   1159 N  ND1 . HIS   A 1 232 ? -24.12107 12.51857  -39.17683 1.000 12.66851 ? 232 HIS   A ND1 1 
ATOM   1160 C  CD2 . HIS   A 1 232 ? -24.35495 11.82916  -37.11624 1.000 12.31205 ? 232 HIS   A CD2 1 
ATOM   1161 C  CE1 . HIS   A 1 232 ? -24.53409 13.55474  -38.46279 1.000 15.23032 ? 232 HIS   A CE1 1 
ATOM   1162 N  NE2 . HIS   A 1 232 ? -24.68827 13.16130  -37.20953 1.000 14.78043 ? 232 HIS   A NE2 1 
ATOM   1163 N  N   . HIS   A 1 233 ? -20.73326 9.70426   -37.47622 1.000 10.53489 ? 233 HIS   A N   1 
ATOM   1164 C  CA  . HIS   A 1 233 ? -19.74534 10.09948  -36.47128 1.000 9.89140  ? 233 HIS   A CA  1 
ATOM   1165 C  C   . HIS   A 1 233 ? -18.47559 10.61987  -37.14364 1.000 9.34975  ? 233 HIS   A C   1 
ATOM   1166 O  O   . HIS   A 1 233 ? -17.92807 11.66125  -36.75275 1.000 8.68014  ? 233 HIS   A O   1 
ATOM   1167 C  CB  . HIS   A 1 233 ? -19.37788 8.92129   -35.54381 1.000 10.28424 ? 233 HIS   A CB  1 
ATOM   1168 C  CG  . HIS   A 1 233 ? -20.53928 8.25873   -34.85928 1.000 12.96545 ? 233 HIS   A CG  1 
ATOM   1169 N  ND1 . HIS   A 1 233 ? -21.57503 8.96336   -34.28157 1.000 9.34546  ? 233 HIS   A ND1 1 
ATOM   1170 C  CD2 . HIS   A 1 233 ? -20.80539 6.94751   -34.63264 1.000 9.18417  ? 233 HIS   A CD2 1 
ATOM   1171 C  CE1 . HIS   A 1 233 ? -22.43821 8.11339   -33.75099 1.000 9.66160  ? 233 HIS   A CE1 1 
ATOM   1172 N  NE2 . HIS   A 1 233 ? -21.98804 6.88660   -33.93843 1.000 12.27281 ? 233 HIS   A NE2 1 
ATOM   1173 N  N   . LEU   A 1 234 ? -18.00478 9.90547   -38.16644 1.000 10.13022 ? 234 LEU   A N   1 
ATOM   1174 C  CA  . LEU   A 1 234 ? -16.83013 10.32841  -38.92749 1.000 8.95681  ? 234 LEU   A CA  1 
ATOM   1175 C  C   . LEU   A 1 234 ? -17.04961 11.68113  -39.58961 1.000 12.02337 ? 234 LEU   A C   1 
ATOM   1176 O  O   . LEU   A 1 234 ? -16.22488 12.59439  -39.45114 1.000 10.39755 ? 234 LEU   A O   1 
ATOM   1177 C  CB  . LEU   A 1 234 ? -16.50336 9.27106   -39.98005 1.000 10.13949 ? 234 LEU   A CB  1 
ATOM   1178 C  CG  . LEU   A 1 234 ? -15.80364 8.03057   -39.42494 1.000 8.69282  ? 234 LEU   A CG  1 
ATOM   1179 C  CD1 . LEU   A 1 234 ? -15.88560 6.86247   -40.41534 1.000 6.88374  ? 234 LEU   A CD1 1 
ATOM   1180 C  CD2 . LEU   A 1 234 ? -14.32409 8.37414   -39.06618 1.000 8.21510  ? 234 LEU   A CD2 1 
ATOM   1181 N  N   . ALA   A 1 235 ? -18.15991 11.82712  -40.32180 1.000 9.11075  ? 235 ALA   A N   1 
ATOM   1182 C  CA  . ALA   A 1 235 ? -18.41357 13.08542  -41.02086 1.000 14.81428 ? 235 ALA   A CA  1 
ATOM   1183 C  C   . ALA   A 1 235 ? -18.43202 14.26890  -40.05243 1.000 12.27169 ? 235 ALA   A C   1 
ATOM   1184 O  O   . ALA   A 1 235 ? -17.83942 15.31584  -40.33512 1.000 13.78894 ? 235 ALA   A O   1 
ATOM   1185 C  CB  . ALA   A 1 235 ? -19.72506 12.99681  -41.80431 1.000 14.88805 ? 235 ALA   A CB  1 
ATOM   1186 N  N   . VAL   A 1 236 ? -19.07312 14.11132  -38.88848 1.000 10.60429 ? 236 VAL   A N   1 
ATOM   1187 C  CA  . VAL   A 1 236 ? -19.10459 15.19518  -37.90608 1.000 11.00415 ? 236 VAL   A CA  1 
ATOM   1188 C  C   . VAL   A 1 236 ? -17.71272 15.43119  -37.31885 1.000 11.96758 ? 236 VAL   A C   1 
ATOM   1189 O  O   . VAL   A 1 236 ? -17.24023 16.57672  -37.24134 1.000 12.86872 ? 236 VAL   A O   1 
ATOM   1190 C  CB  . VAL   A 1 236 ? -20.15573 14.89765  -36.81469 1.000 15.30575 ? 236 VAL   A CB  1 
ATOM   1191 C  CG1 . VAL   A 1 236 ? -20.01308 15.85739  -35.63287 1.000 10.52715 ? 236 VAL   A CG1 1 
ATOM   1192 C  CG2 . VAL   A 1 236 ? -21.58096 14.98594  -37.40252 1.000 13.63855 ? 236 VAL   A CG2 1 
ATOM   1193 N  N   . GLY   A 1 237 ? -17.03543 14.35640  -36.89629 1.000 10.80060 ? 237 GLY   A N   1 
ATOM   1194 C  CA  . GLY   A 1 237 ? -15.70625 14.50091  -36.30500 1.000 9.77999  ? 237 GLY   A CA  1 
ATOM   1195 C  C   . GLY   A 1 237 ? -14.72990 15.24240  -37.20106 1.000 11.29150 ? 237 GLY   A C   1 
ATOM   1196 O  O   . GLY   A 1 237 ? -13.98651 16.11667  -36.73837 1.000 12.23569 ? 237 GLY   A O   1 
ATOM   1197 N  N   . PHE   A 1 238 ? -14.72884 14.91843  -38.50169 1.000 11.41411 ? 238 PHE   A N   1 
ATOM   1198 C  CA  . PHE   A 1 238 ? -13.83070 15.59672  -39.43357 1.000 11.85735 ? 238 PHE   A CA  1 
ATOM   1199 C  C   . PHE   A 1 238 ? -14.30451 17.02041  -39.72716 1.000 12.12171 ? 238 PHE   A C   1 
ATOM   1200 O  O   . PHE   A 1 238 ? -13.48044 17.93692  -39.81248 1.000 13.20693 ? 238 PHE   A O   1 
ATOM   1201 C  CB  . PHE   A 1 238 ? -13.68807 14.79979  -40.74350 1.000 13.17447 ? 238 PHE   A CB  1 
ATOM   1202 C  CG  . PHE   A 1 238 ? -12.84720 13.54455  -40.61980 1.000 16.66924 ? 238 PHE   A CG  1 
ATOM   1203 C  CD1 . PHE   A 1 238 ? -11.49433 13.61281  -40.27668 1.000 15.46967 ? 238 PHE   A CD1 1 
ATOM   1204 C  CD2 . PHE   A 1 238 ? -13.40467 12.29030  -40.86958 1.000 13.38813 ? 238 PHE   A CD2 1 
ATOM   1205 C  CE1 . PHE   A 1 238 ? -10.72027 12.45489  -40.16368 1.000 11.58048 ? 238 PHE   A CE1 1 
ATOM   1206 C  CE2 . PHE   A 1 238 ? -12.62614 11.12458  -40.76261 1.000 15.18032 ? 238 PHE   A CE2 1 
ATOM   1207 C  CZ  . PHE   A 1 238 ? -11.27706 11.21669  -40.39862 1.000 13.26827 ? 238 PHE   A CZ  1 
ATOM   1208 N  N   . LYS   A 1 239 ? -15.62373 17.22657  -39.88206 1.000 9.54681  ? 239 LYS   A N   1 
ATOM   1209 C  CA  . LYS   A 1 239 ? -16.14219 18.55345  -40.20708 1.000 14.55419 ? 239 LYS   A CA  1 
ATOM   1210 C  C   . LYS   A 1 239 ? -15.78450 19.58386  -39.14659 1.000 14.65012 ? 239 LYS   A C   1 
ATOM   1211 O  O   . LYS   A 1 239 ? -15.44775 20.72795  -39.47067 1.000 13.51401 ? 239 LYS   A O   1 
ATOM   1212 C  CB  . LYS   A 1 239 ? -17.66038 18.50360  -40.37588 1.000 14.71159 ? 239 LYS   A CB  1 
ATOM   1213 C  CG  . LYS   A 1 239 ? -18.02965 18.00771  -41.72001 1.000 26.22701 ? 239 LYS   A CG  1 
ATOM   1214 C  CD  . LYS   A 1 239 ? -19.50063 17.77835  -41.85643 1.000 34.17853 ? 239 LYS   A CD  1 
ATOM   1215 C  CE  . LYS   A 1 239 ? -19.90423 18.00349  -43.28386 1.000 34.75141 ? 239 LYS   A CE  1 
ATOM   1216 N  NZ  . LYS   A 1 239 ? -21.38403 18.02696  -43.42327 1.000 40.14559 ? 239 LYS   A NZ  1 
ATOM   1217 N  N   . LEU   A 1 240 ? -15.86300 19.20338  -37.87279 1.000 13.78987 ? 240 LEU   A N   1 
ATOM   1218 C  CA  . LEU   A 1 240 ? -15.57094 20.15694  -36.81049 1.000 12.91554 ? 240 LEU   A CA  1 
ATOM   1219 C  C   . LEU   A 1 240 ? -14.12482 20.63300  -36.84506 1.000 15.75623 ? 240 LEU   A C   1 
ATOM   1220 O  O   . LEU   A 1 240 ? -13.82399 21.68588  -36.27481 1.000 16.67797 ? 240 LEU   A O   1 
ATOM   1221 C  CB  . LEU   A 1 240 ? -15.90418 19.54275  -35.44944 1.000 12.08521 ? 240 LEU   A CB  1 
ATOM   1222 C  CG  . LEU   A 1 240 ? -17.39879 19.27331  -35.23250 1.000 13.37769 ? 240 LEU   A CG  1 
ATOM   1223 C  CD1 . LEU   A 1 240 ? -17.61168 18.45038  -33.95382 1.000 11.38274 ? 240 LEU   A CD1 1 
ATOM   1224 C  CD2 . LEU   A 1 240 ? -18.22449 20.56869  -35.18596 1.000 13.41481 ? 240 LEU   A CD2 1 
ATOM   1225 N  N   . LEU   A 1 241 ? -13.22340 19.89865  -37.50815 1.000 12.53385 ? 241 LEU   A N   1 
ATOM   1226 C  CA  . LEU   A 1 241 ? -11.84727 20.38140  -37.64962 1.000 17.27163 ? 241 LEU   A CA  1 
ATOM   1227 C  C   . LEU   A 1 241 ? -11.77586 21.66473  -38.46176 1.000 16.79254 ? 241 LEU   A C   1 
ATOM   1228 O  O   . LEU   A 1 241 ? -10.76000 22.36879  -38.41153 1.000 16.86845 ? 241 LEU   A O   1 
ATOM   1229 C  CB  . LEU   A 1 241 ? -10.95774 19.33746  -38.32936 1.000 13.31699 ? 241 LEU   A CB  1 
ATOM   1230 C  CG  . LEU   A 1 241 ? -10.65827 18.01230  -37.63686 1.000 15.81187 ? 241 LEU   A CG  1 
ATOM   1231 C  CD1 . LEU   A 1 241 ? -10.10402 16.98460  -38.65405 1.000 12.13187 ? 241 LEU   A CD1 1 
ATOM   1232 C  CD2 . LEU   A 1 241 ? -9.68032  18.23017  -36.49480 1.000 14.68029 ? 241 LEU   A CD2 1 
ATOM   1233 N  N   . GLN   A 1 242 ? -12.81275 21.96916  -39.22629 1.000 15.59848 ? 242 GLN   A N   1 
ATOM   1234 C  CA  . GLN   A 1 242 ? -12.80156 23.13570  -40.09259 1.000 19.94040 ? 242 GLN   A CA  1 
ATOM   1235 C  C   . GLN   A 1 242 ? -13.39902 24.36625  -39.43193 1.000 23.59826 ? 242 GLN   A C   1 
ATOM   1236 O  O   . GLN   A 1 242 ? -13.41133 25.43291  -40.05401 1.000 19.91315 ? 242 GLN   A O   1 
ATOM   1237 C  CB  . GLN   A 1 242 ? -13.53707 22.81868  -41.39714 1.000 19.70805 ? 242 GLN   A CB  1 
ATOM   1238 C  CG  . GLN   A 1 242 ? -12.79252 21.78456  -42.24100 1.000 23.74875 ? 242 GLN   A CG  1 
ATOM   1239 C  CD  . GLN   A 1 242 ? -13.64200 21.20187  -43.34753 1.000 35.78035 ? 242 GLN   A CD  1 
ATOM   1240 O  OE1 . GLN   A 1 242 ? -14.75702 21.66380  -43.59815 1.000 43.34725 ? 242 GLN   A OE1 1 
ATOM   1241 N  NE2 . GLN   A 1 242 ? -13.12461 20.16912  -44.01076 1.000 33.08204 ? 242 GLN   A NE2 1 
ATOM   1242 N  N   . GLU   A 1 243 ? -13.88483 24.24363  -38.19470 1.000 22.41031 ? 243 GLU   A N   1 
ATOM   1243 C  CA  . GLU   A 1 243 ? -14.38288 25.38687  -37.44228 1.000 21.77968 ? 243 GLU   A CA  1 
ATOM   1244 C  C   . GLU   A 1 243 ? -13.22463 26.27980  -37.00345 1.000 23.92807 ? 243 GLU   A C   1 
ATOM   1245 O  O   . GLU   A 1 243 ? -12.05330 25.88418  -37.01037 1.000 19.35675 ? 243 GLU   A O   1 
ATOM   1246 C  CB  . GLU   A 1 243 ? -15.17662 24.92728  -36.21868 1.000 20.50045 ? 243 GLU   A CB  1 
ATOM   1247 C  CG  . GLU   A 1 243 ? -16.39538 24.08145  -36.56581 1.000 23.66409 ? 243 GLU   A CG  1 
ATOM   1248 C  CD  . GLU   A 1 243 ? -17.42456 24.87293  -37.35588 1.000 34.09842 ? 243 GLU   A CD  1 
ATOM   1249 O  OE1 . GLU   A 1 243 ? -17.86194 25.94075  -36.86968 1.000 40.44749 ? 243 GLU   A OE1 1 
ATOM   1250 O  OE2 . GLU   A 1 243 ? -17.78553 24.43355  -38.46422 1.000 31.73706 ? 243 GLU   A OE2 1 
ATOM   1251 N  N   . GLU   A 1 244 ? -13.57439 27.49966  -36.59558 1.000 24.30805 ? 244 GLU   A N   1 
ATOM   1252 C  CA  . GLU   A 1 244 ? -12.57536 28.50659  -36.25159 1.000 23.63957 ? 244 GLU   A CA  1 
ATOM   1253 C  C   . GLU   A 1 244 ? -11.60824 28.00098  -35.18050 1.000 18.24004 ? 244 GLU   A C   1 
ATOM   1254 O  O   . GLU   A 1 244 ? -12.01754 27.63912  -34.06939 1.000 19.71637 ? 244 GLU   A O   1 
ATOM   1255 C  CB  . GLU   A 1 244 ? -13.27982 29.78441  -35.78772 1.000 23.24922 ? 244 GLU   A CB  1 
ATOM   1256 C  CG  . GLU   A 1 244 ? -12.34233 30.90469  -35.40975 1.000 24.51431 ? 244 GLU   A CG  1 
ATOM   1257 C  CD  . GLU   A 1 244 ? -13.08346 32.14790  -34.94305 1.000 26.49074 ? 244 GLU   A CD  1 
ATOM   1258 O  OE1 . GLU   A 1 244 ? -13.28569 33.05841  -35.75906 1.000 29.78937 ? 244 GLU   A OE1 1 
ATOM   1259 O  OE2 . GLU   A 1 244 ? -13.47853 32.19176  -33.76288 1.000 27.39697 ? 244 GLU   A OE2 1 
ATOM   1260 N  N   . ASN   A 1 245 ? -10.31932 27.98438  -35.52820 1.000 16.89336 ? 245 ASN   A N   1 
ATOM   1261 C  CA  . ASN   A 1 245 ? -9.22553  27.57427  -34.63507 1.000 19.11978 ? 245 ASN   A CA  1 
ATOM   1262 C  C   . ASN   A 1 245 ? -9.40361  26.14159  -34.12327 1.000 19.56735 ? 245 ASN   A C   1 
ATOM   1263 O  O   . ASN   A 1 245 ? -9.06271  25.82362  -32.97816 1.000 17.18589 ? 245 ASN   A O   1 
ATOM   1264 C  CB  . ASN   A 1 245 ? -9.05453  28.54826  -33.46601 1.000 16.86493 ? 245 ASN   A CB  1 
ATOM   1265 C  CG  . ASN   A 1 245 ? -7.70926  28.39267  -32.77993 1.000 19.53847 ? 245 ASN   A CG  1 
ATOM   1266 O  OD1 . ASN   A 1 245 ? -6.74414  27.92576  -33.38646 1.000 25.54627 ? 245 ASN   A OD1 1 
ATOM   1267 N  ND2 . ASN   A 1 245 ? -7.63886  28.76821  -31.51033 1.000 19.51197 ? 245 ASN   A ND2 1 
ATOM   1268 N  N   . CYS   A 1 246 ? -9.90348  25.25409  -34.99110 1.000 18.82923 ? 246 CYS   A N   1 
ATOM   1269 C  CA  . CYS   A 1 246 ? -10.13895 23.86194  -34.61764 1.000 15.94676 ? 246 CYS   A CA  1 
ATOM   1270 C  C   . CYS   A 1 246 ? -9.29507  22.83509  -35.36749 1.000 17.87656 ? 246 CYS   A C   1 
ATOM   1271 O  O   . CYS   A 1 246 ? -9.44400  21.63307  -35.09301 1.000 14.52655 ? 246 CYS   A O   1 
ATOM   1272 C  CB  . CYS   A 1 246 ? -11.61990 23.50279  -34.82098 1.000 15.40871 ? 246 CYS   A CB  1 
ATOM   1273 S  SG  . CYS   A 1 246 ? -12.70973 24.15740  -33.54859 1.000 17.77117 ? 246 CYS   A SG  1 
ATOM   1274 N  N   . ASP   A 1 247 ? -8.45931  23.23538  -36.32981 1.000 18.53789 ? 247 ASP   A N   1 
ATOM   1275 C  CA  . ASP   A 1 247 ? -7.73709  22.21353  -37.09815 1.000 20.25488 ? 247 ASP   A CA  1 
ATOM   1276 C  C   . ASP   A 1 247 ? -6.48929  21.80144  -36.33482 1.000 19.08707 ? 247 ASP   A C   1 
ATOM   1277 O  O   . ASP   A 1 247 ? -5.39852  22.35860  -36.52076 1.000 16.55104 ? 247 ASP   A O   1 
ATOM   1278 C  CB  . ASP   A 1 247 ? -7.37333  22.67359  -38.50181 1.000 18.96149 ? 247 ASP   A CB  1 
ATOM   1279 C  CG  . ASP   A 1 247 ? -6.71728  21.53929  -39.32104 1.000 25.43597 ? 247 ASP   A CG  1 
ATOM   1280 O  OD1 . ASP   A 1 247 ? -6.82461  20.35582  -38.89779 1.000 16.33456 ? 247 ASP   A OD1 1 
ATOM   1281 O  OD2 . ASP   A 1 247 ? -6.09783  21.81799  -40.37546 1.000 24.74061 ? 247 ASP   A OD2 1 
ATOM   1282 N  N   . ILE   A 1 248 ? -6.65130  20.77806  -35.48977 1.000 15.55023 ? 248 ILE   A N   1 
ATOM   1283 C  CA  . ILE   A 1 248 ? -5.53025  20.27271  -34.71113 1.000 17.17961 ? 248 ILE   A CA  1 
ATOM   1284 C  C   . ILE   A 1 248 ? -4.48280  19.58074  -35.57637 1.000 16.46529 ? 248 ILE   A C   1 
ATOM   1285 O  O   . ILE   A 1 248 ? -3.37893  19.32673  -35.09373 1.000 14.11088 ? 248 ILE   A O   1 
ATOM   1286 C  CB  . ILE   A 1 248 ? -6.02051  19.32062  -33.59668 1.000 14.57785 ? 248 ILE   A CB  1 
ATOM   1287 C  CG1 . ILE   A 1 248 ? -6.65902  18.06453  -34.19225 1.000 15.19066 ? 248 ILE   A CG1 1 
ATOM   1288 C  CG2 . ILE   A 1 248 ? -7.00297  20.04798  -32.65066 1.000 14.62724 ? 248 ILE   A CG2 1 
ATOM   1289 C  CD1 . ILE   A 1 248 ? -6.97394  16.98526  -33.15005 1.000 14.02604 ? 248 ILE   A CD1 1 
ATOM   1290 N  N   . PHE   A 1 249 ? -4.78545  19.27862  -36.84190 1.000 14.27957 ? 249 PHE   A N   1 
ATOM   1291 C  CA  . PHE   A 1 249 ? -3.80897  18.66557  -37.73406 1.000 15.86377 ? 249 PHE   A CA  1 
ATOM   1292 C  C   . PHE   A 1 249 ? -3.17480  19.67261  -38.69764 1.000 18.08185 ? 249 PHE   A C   1 
ATOM   1293 O  O   . PHE   A 1 249 ? -2.58895  19.26735  -39.71117 1.000 16.19244 ? 249 PHE   A O   1 
ATOM   1294 C  CB  . PHE   A 1 249 ? -4.45719  17.51316  -38.51038 1.000 14.40599 ? 249 PHE   A CB  1 
ATOM   1295 C  CG  . PHE   A 1 249 ? -5.15876  16.52641  -37.62525 1.000 13.37458 ? 249 PHE   A CG  1 
ATOM   1296 C  CD1 . PHE   A 1 249 ? -4.44846  15.80878  -36.67551 1.000 15.10693 ? 249 PHE   A CD1 1 
ATOM   1297 C  CD2 . PHE   A 1 249 ? -6.52604  16.33337  -37.72371 1.000 12.93051 ? 249 PHE   A CD2 1 
ATOM   1298 C  CE1 . PHE   A 1 249 ? -5.08533  14.91029  -35.83696 1.000 18.94359 ? 249 PHE   A CE1 1 
ATOM   1299 C  CE2 . PHE   A 1 249 ? -7.17695  15.43449  -36.88433 1.000 16.64497 ? 249 PHE   A CE2 1 
ATOM   1300 C  CZ  . PHE   A 1 249 ? -6.45809  14.72835  -35.93741 1.000 14.35611 ? 249 PHE   A CZ  1 
ATOM   1301 N  N   . GLN   A 1 250 ? -3.25668  20.97414  -38.38990 1.000 16.24423 ? 250 GLN   A N   1 
ATOM   1302 C  CA  . GLN   A 1 250 ? -2.80840  22.00738  -39.33289 1.000 17.92536 ? 250 GLN   A CA  1 
ATOM   1303 C  C   . GLN   A 1 250 ? -1.32777  21.88646  -39.70507 1.000 18.12385 ? 250 GLN   A C   1 
ATOM   1304 O  O   . GLN   A 1 250 ? -0.93570  22.31813  -40.79705 1.000 17.80016 ? 250 GLN   A O   1 
ATOM   1305 C  CB  . GLN   A 1 250 ? -3.10314  23.40517  -38.76704 1.000 14.54083 ? 250 GLN   A CB  1 
ATOM   1306 C  CG  . GLN   A 1 250 ? -2.55140  23.64440  -37.37683 1.000 16.35558 ? 250 GLN   A CG  1 
ATOM   1307 C  CD  . GLN   A 1 250 ? -2.97495  24.98671  -36.80215 1.000 26.53971 ? 250 GLN   A CD  1 
ATOM   1308 O  OE1 . GLN   A 1 250 ? -2.19131  25.94324  -36.79429 1.000 21.80897 ? 250 GLN   A OE1 1 
ATOM   1309 N  NE2 . GLN   A 1 250 ? -4.21186  25.06365  -36.30355 1.000 19.72688 ? 250 GLN   A NE2 1 
ATOM   1310 N  N   . ASN   A 1 251 ? -0.49988  21.28977  -38.85341 1.000 16.24627 ? 251 ASN   A N   1 
ATOM   1311 C  CA  . ASN   A 1 251 ? 0.93028   21.20441  -39.13093 1.000 18.02764 ? 251 ASN   A CA  1 
ATOM   1312 C  C   . ASN   A 1 251 ? 1.38814   19.80916  -39.54190 1.000 18.01263 ? 251 ASN   A C   1 
ATOM   1313 O  O   . ASN   A 1 251 ? 2.59183   19.57474  -39.65192 1.000 17.13644 ? 251 ASN   A O   1 
ATOM   1314 C  CB  . ASN   A 1 251 ? 1.71547   21.72318  -37.92751 1.000 15.78492 ? 251 ASN   A CB  1 
ATOM   1315 C  CG  . ASN   A 1 251 ? 1.51795   23.20726  -37.73507 1.000 16.55529 ? 251 ASN   A CG  1 
ATOM   1316 O  OD1 . ASN   A 1 251 ? 1.40159   23.95826  -38.71976 1.000 20.52811 ? 251 ASN   A OD1 1 
ATOM   1317 N  ND2 . ASN   A 1 251 ? 1.42786   23.64362  -36.47998 1.000 15.39020 ? 251 ASN   A ND2 1 
ATOM   1318 N  N   . LEU   A 1 252 ? 0.46775   18.88372  -39.80724 1.000 14.63795 ? 252 LEU   A N   1 
ATOM   1319 C  CA  . LEU   A 1 252 ? 0.85792   17.62117  -40.41803 1.000 16.94183 ? 252 LEU   A CA  1 
ATOM   1320 C  C   . LEU   A 1 252 ? 1.14012   17.84867  -41.90249 1.000 19.01326 ? 252 LEU   A C   1 
ATOM   1321 O  O   . LEU   A 1 252 ? 0.56586   18.74542  -42.52140 1.000 20.14422 ? 252 LEU   A O   1 
ATOM   1322 C  CB  . LEU   A 1 252 ? -0.24613  16.56644  -40.23168 1.000 16.79631 ? 252 LEU   A CB  1 
ATOM   1323 C  CG  . LEU   A 1 252 ? -0.27303  15.75085  -38.93143 1.000 16.09007 ? 252 LEU   A CG  1 
ATOM   1324 C  CD1 . LEU   A 1 252 ? -0.36626  16.67214  -37.69798 1.000 13.06433 ? 252 LEU   A CD1 1 
ATOM   1325 C  CD2 . LEU   A 1 252 ? -1.45715  14.73819  -38.95791 1.000 15.36280 ? 252 LEU   A CD2 1 
ATOM   1326 N  N   . THR   A 1 253 ? 2.03450   17.03835  -42.47553 1.000 20.38335 ? 253 THR   A N   1 
ATOM   1327 C  CA  . THR   A 1 253 ? 2.22398   17.06554  -43.92468 1.000 20.19440 ? 253 THR   A CA  1 
ATOM   1328 C  C   . THR   A 1 253 ? 0.96522   16.53134  -44.61751 1.000 24.56584 ? 253 THR   A C   1 
ATOM   1329 O  O   . THR   A 1 253 ? 0.10751   15.91281  -43.97863 1.000 18.28833 ? 253 THR   A O   1 
ATOM   1330 C  CB  . THR   A 1 253 ? 3.43225   16.22472  -44.32644 1.000 25.13788 ? 253 THR   A CB  1 
ATOM   1331 O  OG1 . THR   A 1 253 ? 3.15174   14.84095  -44.06499 1.000 20.27681 ? 253 THR   A OG1 1 
ATOM   1332 C  CG2 . THR   A 1 253 ? 4.69003   16.65472  -43.54222 1.000 19.27115 ? 253 THR   A CG2 1 
ATOM   1333 N  N   . LYS   A 1 254 ? 0.84873   16.75041  -45.93711 1.000 21.38414 ? 254 LYS   A N   1 
ATOM   1334 C  CA  . LYS   A 1 254 ? -0.29996  16.19714  -46.65691 1.000 28.54381 ? 254 LYS   A CA  1 
ATOM   1335 C  C   . LYS   A 1 254 ? -0.30807  14.67509  -46.58583 1.000 25.13549 ? 254 LYS   A C   1 
ATOM   1336 O  O   . LYS   A 1 254 ? -1.37356  14.06027  -46.47087 1.000 29.00989 ? 254 LYS   A O   1 
ATOM   1337 C  CB  . LYS   A 1 254 ? -0.30762  16.61139  -48.13158 1.000 27.32313 ? 254 LYS   A CB  1 
ATOM   1338 C  CG  . LYS   A 1 254 ? -0.51597  18.09343  -48.54273 1.000 34.32830 ? 254 LYS   A CG  1 
ATOM   1339 C  CD  . LYS   A 1 254 ? -1.76860  18.73367  -48.05363 1.000 34.95708 ? 254 LYS   A CD  1 
ATOM   1340 C  CE  . LYS   A 1 254 ? -1.58912  19.18655  -46.66305 1.000 38.97698 ? 254 LYS   A CE  1 
ATOM   1341 N  NZ  . LYS   A 1 254 ? -2.77892  19.93252  -46.20908 1.000 41.08614 ? 254 LYS   A NZ  1 
ATOM   1342 N  N   . LYS   A 1 255 ? 0.86021   14.03754  -46.72723 1.000 23.30622 ? 255 LYS   A N   1 
ATOM   1343 C  CA  . LYS   A 1 255 ? 0.87736   12.58410  -46.61164 1.000 24.34563 ? 255 LYS   A CA  1 
ATOM   1344 C  C   . LYS   A 1 255 ? 0.37447   12.15177  -45.24169 1.000 20.21546 ? 255 LYS   A C   1 
ATOM   1345 O  O   . LYS   A 1 255 ? -0.35653  11.16297  -45.12938 1.000 16.81093 ? 255 LYS   A O   1 
ATOM   1346 C  CB  . LYS   A 1 255 ? 2.27659   11.99514  -46.83409 1.000 25.38492 ? 255 LYS   A CB  1 
ATOM   1347 C  CG  . LYS   A 1 255 ? 3.03257   12.13925  -48.20916 1.000 35.79159 ? 255 LYS   A CG  1 
ATOM   1348 C  CD  . LYS   A 1 255 ? 3.42290   13.51529  -48.58176 1.000 49.13920 ? 255 LYS   A CD  1 
ATOM   1349 C  CE  . LYS   A 1 255 ? 4.24667   14.11740  -47.52047 1.000 47.12801 ? 255 LYS   A CE  1 
ATOM   1350 N  NZ  . LYS   A 1 255 ? 4.36491   15.56055  -47.69634 1.000 42.70851 ? 255 LYS   A NZ  1 
ATOM   1351 N  N   . GLN   A 1 256 ? 0.82614   12.83904  -44.18318 1.000 20.00967 ? 256 GLN   A N   1 
ATOM   1352 C  CA  . GLN   A 1 256 ? 0.38562   12.51490  -42.82684 1.000 17.80498 ? 256 GLN   A CA  1 
ATOM   1353 C  C   . GLN   A 1 256 ? -1.12762  12.65296  -42.68781 1.000 16.07795 ? 256 GLN   A C   1 
ATOM   1354 O  O   . GLN   A 1 256 ? -1.78950  11.75811  -42.14947 1.000 14.53252 ? 256 GLN   A O   1 
ATOM   1355 C  CB  . GLN   A 1 256 ? 1.09249   13.40255  -41.79446 1.000 14.26559 ? 256 GLN   A CB  1 
ATOM   1356 C  CG  . GLN   A 1 256 ? 2.43656   12.84783  -41.31185 1.000 21.35544 ? 256 GLN   A CG  1 
ATOM   1357 C  CD  . GLN   A 1 256 ? 3.24759   13.85823  -40.51217 1.000 19.08978 ? 256 GLN   A CD  1 
ATOM   1358 O  OE1 . GLN   A 1 256 ? 3.07035   15.06519  -40.65689 1.000 18.71499 ? 256 GLN   A OE1 1 
ATOM   1359 N  NE2 . GLN   A 1 256 ? 4.13775   13.36153  -39.65960 1.000 25.07354 ? 256 GLN   A NE2 1 
ATOM   1360 N  N   . ARG   A 1 257 ? -1.68757  13.77977  -43.14315 1.000 16.22471 ? 257 ARG   A N   1 
ATOM   1361 C  CA  . ARG   A 1 257 ? -3.13007  13.98330  -43.05233 1.000 15.59023 ? 257 ARG   A CA  1 
ATOM   1362 C  C   . ARG   A 1 257 ? -3.88327  12.91193  -43.82876 1.000 18.45076 ? 257 ARG   A C   1 
ATOM   1363 O  O   . ARG   A 1 257 ? -4.85734  12.33290  -43.32393 1.000 12.60666 ? 257 ARG   A O   1 
ATOM   1364 C  CB  . ARG   A 1 257 ? -3.50573  15.38190  -43.56411 1.000 19.95985 ? 257 ARG   A CB  1 
ATOM   1365 C  CG  . ARG   A 1 257 ? -2.87842  16.51868  -42.77036 1.000 22.58821 ? 257 ARG   A CG  1 
ATOM   1366 C  CD  . ARG   A 1 257 ? -2.94573  17.87264  -43.50179 1.000 24.26097 ? 257 ARG   A CD  1 
ATOM   1367 N  NE  . ARG   A 1 257 ? -4.31120  18.36685  -43.62412 1.000 33.19680 ? 257 ARG   A NE  1 
ATOM   1368 C  CZ  . ARG   A 1 257 ? -4.90565  19.14599  -42.72449 1.000 28.91881 ? 257 ARG   A CZ  1 
ATOM   1369 N  NH1 . ARG   A 1 257 ? -4.25872  19.51577  -41.63370 1.000 26.94006 ? 257 ARG   A NH1 1 
ATOM   1370 N  NH2 . ARG   A 1 257 ? -6.15248  19.55140  -42.91303 1.000 39.95437 ? 257 ARG   A NH2 1 
ATOM   1371 N  N   . GLN   A 1 258 ? -3.43817  12.62906  -45.05689 1.000 16.38429 ? 258 GLN   A N   1 
ATOM   1372 C  CA  . GLN   A 1 258 ? -4.09731  11.62358  -45.88496 1.000 16.08615 ? 258 GLN   A CA  1 
ATOM   1373 C  C   . GLN   A 1 258 ? -4.07883  10.25499  -45.21253 1.000 15.43612 ? 258 GLN   A C   1 
ATOM   1374 O  O   . GLN   A 1 258 ? -5.11534  9.58071   -45.10435 1.000 12.57510 ? 258 GLN   A O   1 
ATOM   1375 C  CB  . GLN   A 1 258 ? -3.41807  11.57439  -47.25745 1.000 20.11588 ? 258 GLN   A CB  1 
ATOM   1376 C  CG  . GLN   A 1 258 ? -3.97937  10.53690  -48.20954 1.000 21.54073 ? 258 GLN   A CG  1 
ATOM   1377 C  CD  . GLN   A 1 258 ? -3.19529  10.46249  -49.51109 1.000 27.69219 ? 258 GLN   A CD  1 
ATOM   1378 O  OE1 . GLN   A 1 258 ? -3.62240  10.98749  -50.53773 1.000 31.47519 ? 258 GLN   A OE1 1 
ATOM   1379 N  NE2 . GLN   A 1 258 ? -2.03708  9.81590   -49.46795 1.000 26.64049 ? 258 GLN   A NE2 1 
ATOM   1380 N  N   . SER   A 1 259 ? -2.90305  9.82924   -44.74431 1.000 13.98406 ? 259 SER   A N   1 
ATOM   1381 C  CA  . SER   A 1 259 ? -2.80595  8.56063   -44.03160 1.000 13.82251 ? 259 SER   A CA  1 
ATOM   1382 C  C   . SER   A 1 259 ? -3.64745  8.57022   -42.75602 1.000 13.53211 ? 259 SER   A C   1 
ATOM   1383 O  O   . SER   A 1 259 ? -4.36979  7.61107   -42.47426 1.000 12.14674 ? 259 SER   A O   1 
ATOM   1384 C  CB  . SER   A 1 259 ? -1.34385  8.25065   -43.70830 1.000 16.49345 ? 259 SER   A CB  1 
ATOM   1385 O  OG  . SER   A 1 259 ? -1.25484  7.26827   -42.69145 1.000 19.87253 ? 259 SER   A OG  1 
ATOM   1386 N  N   . LEU   A 1 260 ? -3.55128  9.63436   -41.95480 1.000 13.53916 ? 260 LEU   A N   1 
ATOM   1387 C  CA  . LEU   A 1 260 ? -4.35068  9.68122   -40.73265 1.000 12.86317 ? 260 LEU   A CA  1 
ATOM   1388 C  C   . LEU   A 1 260 ? -5.83810  9.58838   -41.04646 1.000 10.86282 ? 260 LEU   A C   1 
ATOM   1389 O  O   . LEU   A 1 260 ? -6.57887  8.85160   -40.37728 1.000 12.50487 ? 260 LEU   A O   1 
ATOM   1390 C  CB  . LEU   A 1 260 ? -4.05865  10.95184  -39.93538 1.000 13.86770 ? 260 LEU   A CB  1 
ATOM   1391 C  CG  . LEU   A 1 260 ? -4.93936  11.00275  -38.66919 1.000 14.79042 ? 260 LEU   A CG  1 
ATOM   1392 C  CD1 . LEU   A 1 260 ? -4.14703  11.22484  -37.39278 1.000 15.54461 ? 260 LEU   A CD1 1 
ATOM   1393 C  CD2 . LEU   A 1 260 ? -6.01723  12.06236  -38.83415 1.000 13.34880 ? 260 LEU   A CD2 1 
ATOM   1394 N  N   . ARG   A 1 261 ? -6.29512  10.32862  -42.05615 1.000 9.28554  ? 261 ARG   A N   1 
ATOM   1395 C  CA  . ARG   A 1 261 ? -7.72029  10.33076  -42.38459 1.000 13.53444 ? 261 ARG   A CA  1 
ATOM   1396 C  C   . ARG   A 1 261 ? -8.21432  8.92319   -42.72922 1.000 14.07841 ? 261 ARG   A C   1 
ATOM   1397 O  O   . ARG   A 1 261 ? -9.26818  8.48238   -42.24026 1.000 10.90822 ? 261 ARG   A O   1 
ATOM   1398 C  CB  . ARG   A 1 261 ? -7.99829  11.29740  -43.53602 1.000 11.25047 ? 261 ARG   A CB  1 
ATOM   1399 C  CG  . ARG   A 1 261 ? -9.45813  11.24070  -44.01778 1.000 11.69608 ? 261 ARG   A CG  1 
ATOM   1400 C  CD  . ARG   A 1 261 ? -9.81133  12.42044  -44.94524 1.000 15.82517 ? 261 ARG   A CD  1 
ATOM   1401 N  NE  . ARG   A 1 261 ? -11.09435 12.19112  -45.62612 1.000 14.77871 ? 261 ARG   A NE  1 
ATOM   1402 C  CZ  . ARG   A 1 261 ? -12.29088 12.43106  -45.09412 1.000 14.36615 ? 261 ARG   A CZ  1 
ATOM   1403 N  NH1 . ARG   A 1 261 ? -12.38864 12.91319  -43.85681 1.000 13.82930 ? 261 ARG   A NH1 1 
ATOM   1404 N  NH2 . ARG   A 1 261 ? -13.39610 12.18461  -45.79842 1.000 12.81882 ? 261 ARG   A NH2 1 
ATOM   1405 N  N   . LYS   A 1 262 ? -7.46203  8.19652   -43.57237 1.000 11.71546 ? 262 LYS   A N   1 
ATOM   1406 C  CA  . LYS   A 1 262 ? -7.88059  6.83988   -43.94473 1.000 11.67668 ? 262 LYS   A CA  1 
ATOM   1407 C  C   . LYS   A 1 262 ? -7.86589  5.89889   -42.74099 1.000 12.49274 ? 262 LYS   A C   1 
ATOM   1408 O  O   . LYS   A 1 262 ? -8.74736  5.05076   -42.60559 1.000 12.03424 ? 262 LYS   A O   1 
ATOM   1409 C  CB  . LYS   A 1 262 ? -6.98475  6.27259   -45.05819 1.000 14.50987 ? 262 LYS   A CB  1 
ATOM   1410 C  CG  . LYS   A 1 262 ? -7.27206  4.78268   -45.36024 1.000 16.86239 ? 262 LYS   A CG  1 
ATOM   1411 C  CD  . LYS   A 1 262 ? -6.36728  4.16451   -46.41549 1.000 20.47702 ? 262 LYS   A CD  1 
ATOM   1412 C  CE  . LYS   A 1 262 ? -7.00379  2.87974   -46.93055 1.000 22.85079 ? 262 LYS   A CE  1 
ATOM   1413 N  NZ  . LYS   A 1 262 ? -8.13768  3.24669   -47.84585 1.000 23.41327 ? 262 LYS   A NZ  1 
ATOM   1414 N  N   . MET   A 1 263 ? -6.84481  5.99623   -41.88080 1.000 12.09296 ? 263 MET   A N   1 
ATOM   1415 C  CA  . MET   A 1 263 ? -6.79539  5.12530   -40.70698 1.000 13.03537 ? 263 MET   A CA  1 
ATOM   1416 C  C   . MET   A 1 263 ? -7.96889  5.38660   -39.76328 1.000 12.73645 ? 263 MET   A C   1 
ATOM   1417 O  O   . MET   A 1 263 ? -8.56574  4.44650   -39.22567 1.000 9.74295  ? 263 MET   A O   1 
ATOM   1418 C  CB  . MET   A 1 263 ? -5.46464  5.31100   -39.96953 1.000 10.27385 ? 263 MET   A CB  1 
ATOM   1419 C  CG  . MET   A 1 263 ? -4.27449  4.68059   -40.70745 1.000 11.60324 ? 263 MET   A CG  1 
ATOM   1420 S  SD  . MET   A 1 263 ? -2.79119  4.62192   -39.68654 1.000 14.71453 ? 263 MET   A SD  1 
ATOM   1421 C  CE  . MET   A 1 263 ? -2.46868  6.36888   -39.51470 1.000 10.22950 ? 263 MET   A CE  1 
ATOM   1422 N  N   . VAL   A 1 264 ? -8.31307  6.65948   -39.55346 1.000 11.30236 ? 264 VAL   A N   1 
ATOM   1423 C  CA  . VAL   A 1 264 ? -9.43103  7.00783   -38.67819 1.000 10.90211 ? 264 VAL   A CA  1 
ATOM   1424 C  C   . VAL   A 1 264 ? -10.74677 6.45171   -39.22483 1.000 8.95823  ? 264 VAL   A C   1 
ATOM   1425 O  O   . VAL   A 1 264 ? -11.56887 5.90400   -38.47560 1.000 10.86810 ? 264 VAL   A O   1 
ATOM   1426 C  CB  . VAL   A 1 264 ? -9.47809  8.53897   -38.48238 1.000 10.46111 ? 264 VAL   A CB  1 
ATOM   1427 C  CG1 . VAL   A 1 264 ? -10.79816 8.97426   -37.82586 1.000 6.70343  ? 264 VAL   A CG1 1 
ATOM   1428 C  CG2 . VAL   A 1 264 ? -8.25450  8.99804   -37.63936 1.000 9.20355  ? 264 VAL   A CG2 1 
ATOM   1429 N  N   . ILE   A 1 265 ? -10.96457 6.57874   -40.53584 1.000 8.88071  ? 265 ILE   A N   1 
ATOM   1430 C  CA  . ILE   A 1 265 ? -12.16846 6.03964   -41.16966 1.000 9.76453  ? 265 ILE   A CA  1 
ATOM   1431 C  C   . ILE   A 1 265 ? -12.24331 4.52595   -40.99404 1.000 10.12445 ? 265 ILE   A C   1 
ATOM   1432 O  O   . ILE   A 1 265 ? -13.28946 3.98197   -40.60958 1.000 10.70393 ? 265 ILE   A O   1 
ATOM   1433 C  CB  . ILE   A 1 265 ? -12.20158 6.42980   -42.66069 1.000 9.86570  ? 265 ILE   A CB  1 
ATOM   1434 C  CG1 . ILE   A 1 265 ? -12.54411 7.91971   -42.81566 1.000 7.14527  ? 265 ILE   A CG1 1 
ATOM   1435 C  CG2 . ILE   A 1 265 ? -13.16326 5.50818   -43.43372 1.000 7.40452  ? 265 ILE   A CG2 1 
ATOM   1436 C  CD1 . ILE   A 1 265 ? -12.18169 8.50914   -44.14112 1.000 8.91460  ? 265 ILE   A CD1 1 
ATOM   1437 N  N   . ASP   A 1 266 ? -11.14624 3.82650   -41.30580 1.000 9.73551  ? 266 ASP   A N   1 
ATOM   1438 C  CA  . ASP   A 1 266 ? -11.09390 2.37407   -41.16293 1.000 10.81882 ? 266 ASP   A CA  1 
ATOM   1439 C  C   . ASP   A 1 266 ? -11.37188 1.95267   -39.72309 1.000 12.72792 ? 266 ASP   A C   1 
ATOM   1440 O  O   . ASP   A 1 266 ? -12.00959 0.92152   -39.48193 1.000 11.27138 ? 266 ASP   A O   1 
ATOM   1441 C  CB  . ASP   A 1 266 ? -9.71786  1.84004   -41.61199 1.000 11.02369 ? 266 ASP   A CB  1 
ATOM   1442 C  CG  . ASP   A 1 266 ? -9.48498  1.93723   -43.13571 1.000 11.39043 ? 266 ASP   A CG  1 
ATOM   1443 O  OD1 . ASP   A 1 266 ? -10.44266 2.17022   -43.88753 1.000 10.26737 ? 266 ASP   A OD1 1 
ATOM   1444 O  OD2 . ASP   A 1 266 ? -8.32581  1.76915   -43.58773 1.000 14.00462 ? 266 ASP   A OD2 1 
ATOM   1445 N  N   . ILE   A 1 267 ? -10.92166 2.74076   -38.74402 1.000 13.23441 ? 267 ILE   A N   1 
ATOM   1446 C  CA  . ILE   A 1 267 ? -11.14457 2.34507   -37.35533 1.000 10.31112 ? 267 ILE   A CA  1 
ATOM   1447 C  C   . ILE   A 1 267 ? -12.59670 2.58767   -36.95008 1.000 12.34988 ? 267 ILE   A C   1 
ATOM   1448 O  O   . ILE   A 1 267 ? -13.25383 1.70452   -36.38751 1.000 11.72258 ? 267 ILE   A O   1 
ATOM   1449 C  CB  . ILE   A 1 267 ? -10.16545 3.07075   -36.41409 1.000 10.96287 ? 267 ILE   A CB  1 
ATOM   1450 C  CG1 . ILE   A 1 267 ? -8.73685  2.53421   -36.62683 1.000 11.65020 ? 267 ILE   A CG1 1 
ATOM   1451 C  CG2 . ILE   A 1 267 ? -10.62328 2.90680   -34.96649 1.000 7.25309  ? 267 ILE   A CG2 1 
ATOM   1452 C  CD1 . ILE   A 1 267 ? -7.65221  3.32843   -35.95002 1.000 10.80364 ? 267 ILE   A CD1 1 
ATOM   1453 N  N   . VAL   A 1 268 ? -13.11656 3.78956   -37.20647 1.000 11.04944 ? 268 VAL   A N   1 
ATOM   1454 C  CA  . VAL   A 1 268 ? -14.46480 4.09366   -36.73704 1.000 10.36395 ? 268 VAL   A CA  1 
ATOM   1455 C  C   . VAL   A 1 268 ? -15.50465 3.22114   -37.44670 1.000 12.33931 ? 268 VAL   A C   1 
ATOM   1456 O  O   . VAL   A 1 268 ? -16.48828 2.78989   -36.82864 1.000 10.23459 ? 268 VAL   A O   1 
ATOM   1457 C  CB  . VAL   A 1 268 ? -14.77099 5.59455   -36.88321 1.000 10.11001 ? 268 VAL   A CB  1 
ATOM   1458 C  CG1 . VAL   A 1 268 ? -16.26195 5.86990   -36.55046 1.000 7.00333  ? 268 VAL   A CG1 1 
ATOM   1459 C  CG2 . VAL   A 1 268 ? -13.86477 6.41261   -35.96916 1.000 8.13774  ? 268 VAL   A CG2 1 
ATOM   1460 N  N   . LEU   A 1 269 ? -15.30573 2.91374   -38.73401 1.000 10.21341 ? 269 LEU   A N   1 
ATOM   1461 C  CA  . LEU   A 1 269 ? -16.30351 2.07457   -39.40594 1.000 11.69145 ? 269 LEU   A CA  1 
ATOM   1462 C  C   . LEU   A 1 269 ? -16.34679 0.67457   -38.80240 1.000 13.31559 ? 269 LEU   A C   1 
ATOM   1463 O  O   . LEU   A 1 269 ? -17.40155 0.03815   -38.80256 1.000 12.28797 ? 269 LEU   A O   1 
ATOM   1464 C  CB  . LEU   A 1 269 ? -16.05203 2.00201   -40.91048 1.000 9.95126  ? 269 LEU   A CB  1 
ATOM   1465 C  CG  . LEU   A 1 269 ? -16.41271 3.26668   -41.71499 1.000 12.21779 ? 269 LEU   A CG  1 
ATOM   1466 C  CD1 . LEU   A 1 269 ? -16.07222 3.07218   -43.20649 1.000 11.02679 ? 269 LEU   A CD1 1 
ATOM   1467 C  CD2 . LEU   A 1 269 ? -17.87875 3.64133   -41.55978 1.000 11.21616 ? 269 LEU   A CD2 1 
ATOM   1468 N  N   . ALA   A 1 270 ? -15.23045 0.20620   -38.23336 1.000 13.40042 ? 270 ALA   A N   1 
ATOM   1469 C  CA  . ALA   A 1 270 ? -15.15594 -1.10042  -37.58951 1.000 14.96813 ? 270 ALA   A CA  1 
ATOM   1470 C  C   . ALA   A 1 270 ? -15.81467 -1.14322  -36.21523 1.000 11.08154 ? 270 ALA   A C   1 
ATOM   1471 O  O   . ALA   A 1 270 ? -15.92472 -2.23569  -35.64247 1.000 13.06476 ? 270 ALA   A O   1 
ATOM   1472 C  CB  . ALA   A 1 270 ? -13.69116 -1.55394  -37.45597 1.000 12.15367 ? 270 ALA   A CB  1 
ATOM   1473 N  N   . THR   A 1 271 ? -16.24758 -0.00222  -35.66323 1.000 11.37240 ? 271 THR   A N   1 
ATOM   1474 C  CA  . THR   A 1 271 ? -16.98374 -0.04947  -34.40549 1.000 12.55883 ? 271 THR   A CA  1 
ATOM   1475 C  C   . THR   A 1 271 ? -18.44143 -0.43485  -34.61678 1.000 12.66337 ? 271 THR   A C   1 
ATOM   1476 O  O   . THR   A 1 271 ? -19.14222 -0.70637  -33.63747 1.000 14.07727 ? 271 THR   A O   1 
ATOM   1477 C  CB  . THR   A 1 271 ? -16.93746 1.29354   -33.64682 1.000 13.04809 ? 271 THR   A CB  1 
ATOM   1478 O  OG1 . THR   A 1 271 ? -17.52938 2.34814   -34.43341 1.000 9.89522  ? 271 THR   A OG1 1 
ATOM   1479 C  CG2 . THR   A 1 271 ? -15.51169 1.67405   -33.24215 1.000 9.89884  ? 271 THR   A CG2 1 
ATOM   1480 N  N   . ASP   A 1 272 ? -18.90823 -0.45986  -35.86047 1.000 9.38587  ? 272 ASP   A N   1 
ATOM   1481 C  CA  . ASP   A 1 272 ? -20.25996 -0.93387  -36.15297 1.000 12.20626 ? 272 ASP   A CA  1 
ATOM   1482 C  C   . ASP   A 1 272 ? -20.40911 -2.38812  -35.69746 1.000 14.68867 ? 272 ASP   A C   1 
ATOM   1483 O  O   . ASP   A 1 272 ? -19.72624 -3.27284  -36.21705 1.000 13.31046 ? 272 ASP   A O   1 
ATOM   1484 C  CB  . ASP   A 1 272 ? -20.51465 -0.79038  -37.65747 1.000 14.79863 ? 272 ASP   A CB  1 
ATOM   1485 C  CG  . ASP   A 1 272 ? -21.91726 -1.23538  -38.09510 1.000 13.88767 ? 272 ASP   A CG  1 
ATOM   1486 O  OD1 . ASP   A 1 272 ? -22.70028 -1.77417  -37.28968 1.000 13.51745 ? 272 ASP   A OD1 1 
ATOM   1487 O  OD2 . ASP   A 1 272 ? -22.21967 -1.03373  -39.28742 1.000 15.79846 ? 272 ASP   A OD2 1 
ATOM   1488 N  N   . MET   A 1 273 ? -21.30501 -2.64257  -34.72892 1.000 13.76364 ? 273 MET   A N   1 
ATOM   1489 C  CA  . MET   A 1 273 ? -21.46900 -4.00723  -34.21988 1.000 16.98473 ? 273 MET   A CA  1 
ATOM   1490 C  C   . MET   A 1 273 ? -21.84302 -5.01260  -35.30429 1.000 17.65184 ? 273 MET   A C   1 
ATOM   1491 O  O   . MET   A 1 273 ? -21.64224 -6.21553  -35.10782 1.000 19.44080 ? 273 MET   A O   1 
ATOM   1492 C  CB  . MET   A 1 273 ? -22.53326 -4.08093  -33.11472 1.000 19.82321 ? 273 MET   A CB  1 
ATOM   1493 C  CG  . MET   A 1 273 ? -22.00685 -3.96824  -31.68924 1.000 25.53729 ? 273 MET   A CG  1 
ATOM   1494 S  SD  . MET   A 1 273 ? -20.75877 -5.16982  -31.17651 1.000 27.97062 ? 273 MET   A SD  1 
ATOM   1495 C  CE  . MET   A 1 273 ? -21.69001 -6.66908  -31.39496 1.000 24.98687 ? 273 MET   A CE  1 
ATOM   1496 N  N   . SER   A 1 274 ? -22.39091 -4.57502  -36.43688 1.000 17.50482 ? 274 SER   A N   1 
ATOM   1497 C  CA  . SER   A 1 274 ? -22.69021 -5.59026  -37.44359 1.000 22.30426 ? 274 SER   A CA  1 
ATOM   1498 C  C   . SER   A 1 274 ? -21.43165 -6.11508  -38.12120 1.000 23.17108 ? 274 SER   A C   1 
ATOM   1499 O  O   . SER   A 1 274 ? -21.52012 -7.08382  -38.88125 1.000 22.23144 ? 274 SER   A O   1 
ATOM   1500 C  CB  . SER   A 1 274 ? -23.66615 -5.05273  -38.48969 1.000 18.42166 ? 274 SER   A CB  1 
ATOM   1501 O  OG  . SER   A 1 274 ? -23.08797 -3.98554  -39.20342 1.000 28.95711 ? 274 SER   A OG  1 
ATOM   1502 N  N   . LYS   A 1 275 ? -20.27428 -5.49495  -37.87132 1.000 18.84478 ? 275 LYS   A N   1 
ATOM   1503 C  CA  . LYS   A 1 275 ? -18.99014 -5.97648  -38.35953 1.000 18.58656 ? 275 LYS   A CA  1 
ATOM   1504 C  C   . LYS   A 1 275 ? -18.29514 -6.89471  -37.36584 1.000 16.76389 ? 275 LYS   A C   1 
ATOM   1505 O  O   . LYS   A 1 275 ? -17.24355 -7.43876  -37.69766 1.000 15.56210 ? 275 LYS   A O   1 
ATOM   1506 C  CB  . LYS   A 1 275 ? -18.04508 -4.80259  -38.66882 1.000 17.87830 ? 275 LYS   A CB  1 
ATOM   1507 C  CG  . LYS   A 1 275 ? -18.60295 -3.71615  -39.57838 1.000 17.47036 ? 275 LYS   A CG  1 
ATOM   1508 C  CD  . LYS   A 1 275 ? -19.14189 -4.31624  -40.86231 1.000 28.31755 ? 275 LYS   A CD  1 
ATOM   1509 C  CE  . LYS   A 1 275 ? -19.54258 -3.22371  -41.84962 1.000 35.35000 ? 275 LYS   A CE  1 
ATOM   1510 N  NZ  . LYS   A 1 275 ? -18.36917 -2.41409  -42.28779 1.000 33.83182 ? 275 LYS   A NZ  1 
ATOM   1511 N  N   . HIS   A 1 276 ? -18.84259 -7.05941  -36.15703 1.000 15.84638 ? 276 HIS   A N   1 
ATOM   1512 C  CA  . HIS   A 1 276 ? -18.08508 -7.67576  -35.06872 1.000 18.10354 ? 276 HIS   A CA  1 
ATOM   1513 C  C   . HIS   A 1 276 ? -17.68519 -9.11802  -35.39287 1.000 19.51619 ? 276 HIS   A C   1 
ATOM   1514 O  O   . HIS   A 1 276 ? -16.53979 -9.52268  -35.16012 1.000 17.89930 ? 276 HIS   A O   1 
ATOM   1515 C  CB  . HIS   A 1 276 ? -18.89832 -7.62007  -33.77485 1.000 15.77861 ? 276 HIS   A CB  1 
ATOM   1516 C  CG  . HIS   A 1 276 ? -18.47816 -8.63235  -32.75489 1.000 18.51168 ? 276 HIS   A CG  1 
ATOM   1517 N  ND1 . HIS   A 1 276 ? -17.47146 -8.39831  -31.84218 1.000 18.60685 ? 276 HIS   A ND1 1 
ATOM   1518 C  CD2 . HIS   A 1 276 ? -18.91753 -9.89110  -32.51499 1.000 19.60603 ? 276 HIS   A CD2 1 
ATOM   1519 C  CE1 . HIS   A 1 276 ? -17.32024 -9.46383  -31.07559 1.000 20.68186 ? 276 HIS   A CE1 1 
ATOM   1520 N  NE2 . HIS   A 1 276 ? -18.18422 -10.38468 -31.46423 1.000 16.29452 ? 276 HIS   A NE2 1 
ATOM   1521 N  N   . MET   A 1 277 ? -18.61664 -9.91484  -35.92174 1.000 19.22514 ? 277 MET   A N   1 
ATOM   1522 C  CA  . MET   A 1 277 ? -18.32281 -11.33114 -36.13418 1.000 21.50279 ? 277 MET   A CA  1 
ATOM   1523 C  C   . MET   A 1 277 ? -17.16392 -11.51311 -37.10271 1.000 19.66582 ? 277 MET   A C   1 
ATOM   1524 O  O   . MET   A 1 277 ? -16.22516 -12.26598 -36.82709 1.000 23.01902 ? 277 MET   A O   1 
ATOM   1525 C  CB  . MET   A 1 277 ? -19.56910 -12.06852 -36.63425 1.000 23.50931 ? 277 MET   A CB  1 
ATOM   1526 C  CG  . MET   A 1 277 ? -20.63656 -12.24327 -35.56184 1.000 25.57171 ? 277 MET   A CG  1 
ATOM   1527 S  SD  . MET   A 1 277 ? -20.05158 -13.18110 -34.12759 1.000 44.52289 ? 277 MET   A SD  1 
ATOM   1528 C  CE  . MET   A 1 277 ? -21.53808 -13.19978 -33.11818 1.000 37.64064 ? 277 MET   A CE  1 
ATOM   1529 N  N   . ASN   A 1 278 ? -17.20545 -10.81265 -38.23982 1.000 23.05574 ? 278 ASN   A N   1 
ATOM   1530 C  CA  . ASN   A 1 278 ? -16.10577 -10.88759 -39.19652 1.000 22.08730 ? 278 ASN   A CA  1 
ATOM   1531 C  C   . ASN   A 1 278 ? -14.82020 -10.31610 -38.61352 1.000 25.73510 ? 278 ASN   A C   1 
ATOM   1532 O  O   . ASN   A 1 278 ? -13.73578 -10.86724 -38.82524 1.000 21.14201 ? 278 ASN   A O   1 
ATOM   1533 C  CB  . ASN   A 1 278 ? -16.48033 -10.15229 -40.48477 1.000 28.49544 ? 278 ASN   A CB  1 
ATOM   1534 C  CG  . ASN   A 1 278 ? -17.51395 -10.90096 -41.29218 1.000 29.93167 ? 278 ASN   A CG  1 
ATOM   1535 O  OD1 . ASN   A 1 278 ? -17.80296 -12.06331 -41.01575 1.000 40.17654 ? 278 ASN   A OD1 1 
ATOM   1536 N  ND2 . ASN   A 1 278 ? -18.06095 -10.25165 -42.30937 1.000 33.18033 ? 278 ASN   A ND2 1 
ATOM   1537 N  N   . LEU   A 1 279 ? -14.92408 -9.20810  -37.87597 1.000 22.47385 ? 279 LEU   A N   1 
ATOM   1538 C  CA  . LEU   A 1 279 ? -13.75586 -8.63221  -37.22461 1.000 20.38103 ? 279 LEU   A CA  1 
ATOM   1539 C  C   . LEU   A 1 279 ? -13.12911 -9.61373  -36.23708 1.000 19.73502 ? 279 LEU   A C   1 
ATOM   1540 O  O   . LEU   A 1 279 ? -11.90017 -9.76444  -36.19779 1.000 20.00002 ? 279 LEU   A O   1 
ATOM   1541 C  CB  . LEU   A 1 279 ? -14.15326 -7.33643  -36.51890 1.000 19.83593 ? 279 LEU   A CB  1 
ATOM   1542 C  CG  . LEU   A 1 279 ? -13.06093 -6.30861  -36.25533 1.000 20.21460 ? 279 LEU   A CG  1 
ATOM   1543 C  CD1 . LEU   A 1 279 ? -12.52395 -5.83188  -37.57297 1.000 16.71853 ? 279 LEU   A CD1 1 
ATOM   1544 C  CD2 . LEU   A 1 279 ? -13.60692 -5.12484  -35.40672 1.000 18.65535 ? 279 LEU   A CD2 1 
ATOM   1545 N  N   . LEU   A 1 280 ? -13.95593 -10.28745 -35.42650 1.000 17.67656 ? 280 LEU   A N   1 
ATOM   1546 C  CA  . LEU   A 1 280 ? -13.42478 -11.26302 -34.47060 1.000 17.44912 ? 280 LEU   A CA  1 
ATOM   1547 C  C   . LEU   A 1 280 ? -12.83758 -12.48275 -35.18285 1.000 19.09767 ? 280 LEU   A C   1 
ATOM   1548 O  O   . LEU   A 1 280 ? -11.78576 -12.99477 -34.77972 1.000 15.28489 ? 280 LEU   A O   1 
ATOM   1549 C  CB  . LEU   A 1 280 ? -14.51276 -11.69318 -33.48163 1.000 16.93910 ? 280 LEU   A CB  1 
ATOM   1550 C  CG  . LEU   A 1 280 ? -14.12757 -12.77719 -32.45151 1.000 19.89823 ? 280 LEU   A CG  1 
ATOM   1551 C  CD1 . LEU   A 1 280 ? -12.89750 -12.39027 -31.64605 1.000 13.94859 ? 280 LEU   A CD1 1 
ATOM   1552 C  CD2 . LEU   A 1 280 ? -15.29361 -13.10625 -31.51328 1.000 18.26392 ? 280 LEU   A CD2 1 
ATOM   1553 N  N   . ALA   A 1 281 ? -13.51562 -12.96374 -36.23103 1.000 20.43510 ? 281 ALA   A N   1 
ATOM   1554 C  CA  . ALA   A 1 281 ? -13.00060 -14.07727 -37.02062 1.000 20.34404 ? 281 ALA   A CA  1 
ATOM   1555 C  C   . ALA   A 1 281 ? -11.61682 -13.77277 -37.57397 1.000 23.40966 ? 281 ALA   A C   1 
ATOM   1556 O  O   . ALA   A 1 281 ? -10.72584 -14.62691 -37.52653 1.000 22.10795 ? 281 ALA   A O   1 
ATOM   1557 C  CB  . ALA   A 1 281 ? -13.96779 -14.40860 -38.15623 1.000 21.87129 ? 281 ALA   A CB  1 
ATOM   1558 N  N   . ASP   A 1 282 ? -11.40917 -12.55722 -38.09665 1.000 24.94859 ? 282 ASP   A N   1 
ATOM   1559 C  CA  . ASP   A 1 282 ? -10.08859 -12.20364 -38.61907 1.000 19.58548 ? 282 ASP   A CA  1 
ATOM   1560 C  C   . ASP   A 1 282 ? -9.06076  -12.11091 -37.50891 1.000 23.91433 ? 282 ASP   A C   1 
ATOM   1561 O  O   . ASP   A 1 282 ? -7.89688  -12.49742 -37.69781 1.000 22.17349 ? 282 ASP   A O   1 
ATOM   1562 C  CB  . ASP   A 1 282 ? -10.14639 -10.88101 -39.37958 1.000 29.03841 ? 282 ASP   A CB  1 
ATOM   1563 C  CG  . ASP   A 1 282 ? -10.44920 -11.06011 -40.84792 1.000 33.32598 ? 282 ASP   A CG  1 
ATOM   1564 O  OD1 . ASP   A 1 282 ? -10.85554 -12.17177 -41.25291 1.000 37.70242 ? 282 ASP   A OD1 1 
ATOM   1565 O  OD2 . ASP   A 1 282 ? -10.29939 -10.06927 -41.59568 1.000 41.28509 ? 282 ASP   A OD2 1 
ATOM   1566 N  N   . LEU   A 1 283 ? -9.45991  -11.57479 -36.34968 1.000 20.78173 ? 283 LEU   A N   1 
ATOM   1567 C  CA  . LEU   A 1 283 ? -8.51554  -11.44232 -35.24521 1.000 18.90210 ? 283 LEU   A CA  1 
ATOM   1568 C  C   . LEU   A 1 283 ? -8.07973  -12.80961 -34.73148 1.000 20.84085 ? 283 LEU   A C   1 
ATOM   1569 O  O   . LEU   A 1 283 ? -6.92289  -12.99427 -34.33873 1.000 18.93264 ? 283 LEU   A O   1 
ATOM   1570 C  CB  . LEU   A 1 283 ? -9.13613  -10.62850 -34.11609 1.000 17.59124 ? 283 LEU   A CB  1 
ATOM   1571 C  CG  . LEU   A 1 283 ? -8.20998  -10.37923 -32.92970 1.000 18.16164 ? 283 LEU   A CG  1 
ATOM   1572 C  CD1 . LEU   A 1 283 ? -7.08680  -9.42221  -33.32720 1.000 18.64421 ? 283 LEU   A CD1 1 
ATOM   1573 C  CD2 . LEU   A 1 283 ? -9.00652  -9.86153  -31.72267 1.000 17.69797 ? 283 LEU   A CD2 1 
ATOM   1574 N  N   . LYS   A 1 284 ? -9.00529  -13.76518 -34.69282 1.000 19.73873 ? 284 LYS   A N   1 
ATOM   1575 C  CA  . LYS   A 1 284 ? -8.64310  -15.13895 -34.36340 1.000 19.92725 ? 284 LYS   A CA  1 
ATOM   1576 C  C   . LYS   A 1 284 ? -7.58811  -15.67036 -35.32461 1.000 18.75742 ? 284 LYS   A C   1 
ATOM   1577 O  O   . LYS   A 1 284 ? -6.59202  -16.26909 -34.90416 1.000 19.19776 ? 284 LYS   A O   1 
ATOM   1578 C  CB  . LYS   A 1 284 ? -9.88518  -16.02614 -34.39635 1.000 17.43437 ? 284 LYS   A CB  1 
ATOM   1579 C  CG  . LYS   A 1 284 ? -10.87592 -15.75195 -33.26752 1.000 22.07580 ? 284 LYS   A CG  1 
ATOM   1580 C  CD  . LYS   A 1 284 ? -11.90148 -16.86734 -33.17577 1.000 23.50166 ? 284 LYS   A CD  1 
ATOM   1581 C  CE  . LYS   A 1 284 ? -12.05281 -17.35993 -31.74938 1.000 29.96939 ? 284 LYS   A CE  1 
ATOM   1582 N  NZ  . LYS   A 1 284 ? -13.28922 -16.84940 -31.09962 1.000 34.44251 ? 284 LYS   A NZ  1 
ATOM   1583 N  N   . THR   A 1 285 ? -7.79703  -15.46474 -36.62621 1.000 18.58892 ? 285 THR   A N   1 
ATOM   1584 C  CA  . THR   A 1 285 ? -6.82838  -15.93679 -37.60993 1.000 19.82039 ? 285 THR   A CA  1 
ATOM   1585 C  C   . THR   A 1 285 ? -5.45448  -15.32845 -37.34619 1.000 24.66317 ? 285 THR   A C   1 
ATOM   1586 O  O   . THR   A 1 285 ? -4.44335  -16.04149 -37.31212 1.000 21.66375 ? 285 THR   A O   1 
ATOM   1587 C  CB  . THR   A 1 285 ? -7.32825  -15.61787 -39.01784 1.000 20.11672 ? 285 THR   A CB  1 
ATOM   1588 O  OG1 . THR   A 1 285 ? -8.56725  -16.30860 -39.24283 1.000 20.91909 ? 285 THR   A OG1 1 
ATOM   1589 C  CG2 . THR   A 1 285 ? -6.30866  -16.02613 -40.07237 1.000 21.10103 ? 285 THR   A CG2 1 
ATOM   1590 N  N   . MET   A 1 286 ? -5.40974  -14.01617 -37.08700 1.000 19.94528 ? 286 MET   A N   1 
ATOM   1591 C  CA  . MET   A 1 286 ? -4.14285  -13.37497 -36.74999 1.000 19.69629 ? 286 MET   A CA  1 
ATOM   1592 C  C   . MET   A 1 286 ? -3.49568  -14.00181 -35.51837 1.000 21.84151 ? 286 MET   A C   1 
ATOM   1593 O  O   . MET   A 1 286 ? -2.28178  -14.23554 -35.50537 1.000 23.60569 ? 286 MET   A O   1 
ATOM   1594 C  CB  . MET   A 1 286 ? -4.33152  -11.86772 -36.53335 1.000 19.72732 ? 286 MET   A CB  1 
ATOM   1595 C  CG  . MET   A 1 286 ? -3.10136  -11.22890 -35.88266 1.000 20.96075 ? 286 MET   A CG  1 
ATOM   1596 S  SD  . MET   A 1 286 ? -2.97016  -9.42693  -35.92391 1.000 26.15742 ? 286 MET   A SD  1 
ATOM   1597 C  CE  . MET   A 1 286 ? -3.20905  -9.10687  -37.67281 1.000 25.30536 ? 286 MET   A CE  1 
ATOM   1598 N  N   . VAL   A 1 287 ? -4.27469  -14.27450 -34.46616 1.000 20.34293 ? 287 VAL   A N   1 
ATOM   1599 C  CA  . VAL   A 1 287 ? -3.68914  -14.86660 -33.25929 1.000 20.35057 ? 287 VAL   A CA  1 
ATOM   1600 C  C   . VAL   A 1 287 ? -3.11213  -16.24946 -33.56580 1.000 21.47758 ? 287 VAL   A C   1 
ATOM   1601 O  O   . VAL   A 1 287 ? -2.03148  -16.61039 -33.09166 1.000 21.44348 ? 287 VAL   A O   1 
ATOM   1602 C  CB  . VAL   A 1 287 ? -4.73218  -14.92907 -32.12567 1.000 23.01410 ? 287 VAL   A CB  1 
ATOM   1603 C  CG1 . VAL   A 1 287 ? -4.20025  -15.75181 -30.94132 1.000 21.81686 ? 287 VAL   A CG1 1 
ATOM   1604 C  CG2 . VAL   A 1 287 ? -5.11023  -13.52724 -31.66527 1.000 21.70201 ? 287 VAL   A CG2 1 
ATOM   1605 N  N   . GLU   A 1 288 ? -3.82518  -17.03739 -34.36627 1.000 18.92401 ? 288 GLU   A N   1 
ATOM   1606 C  CA  . GLU   A 1 288 ? -3.37607  -18.38708 -34.68790 1.000 23.84633 ? 288 GLU   A CA  1 
ATOM   1607 C  C   . GLU   A 1 288 ? -2.08513  -18.38392 -35.51881 1.000 27.02797 ? 288 GLU   A C   1 
ATOM   1608 O  O   . GLU   A 1 288 ? -1.29009  -19.32968 -35.43181 1.000 25.67254 ? 288 GLU   A O   1 
ATOM   1609 C  CB  . GLU   A 1 288 ? -4.51433  -19.12919 -35.40298 1.000 22.11852 ? 288 GLU   A CB  1 
ATOM   1610 C  CG  . GLU   A 1 288 ? -4.17728  -20.54703 -35.84267 1.000 29.73668 ? 288 GLU   A CG  1 
ATOM   1611 C  CD  . GLU   A 1 288 ? -3.87267  -21.46654 -34.65943 1.000 36.59194 ? 288 GLU   A CD  1 
ATOM   1612 O  OE1 . GLU   A 1 288 ? -4.46496  -21.27288 -33.57607 1.000 35.18478 ? 288 GLU   A OE1 1 
ATOM   1613 O  OE2 . GLU   A 1 288 ? -3.01126  -22.37025 -34.80058 1.000 33.88709 ? 288 GLU   A OE2 1 
ATOM   1614 N  N   . THR   A 1 289 ? -1.84067  -17.32133 -36.29307 1.000 22.46968 ? 289 THR   A N   1 
ATOM   1615 C  CA  . THR   A 1 289 ? -0.68768  -17.22705 -37.18102 1.000 21.18712 ? 289 THR   A CA  1 
ATOM   1616 C  C   . THR   A 1 289 ? 0.26141   -16.10218 -36.77975 1.000 26.15564 ? 289 THR   A C   1 
ATOM   1617 O  O   . THR   A 1 289 ? 1.04437   -15.63801 -37.61288 1.000 22.74528 ? 289 THR   A O   1 
ATOM   1618 C  CB  . THR   A 1 289 ? -1.14614  -17.02487 -38.62763 1.000 22.32774 ? 289 THR   A CB  1 
ATOM   1619 O  OG1 . THR   A 1 289 ? -1.91491  -15.81354 -38.72069 1.000 24.89888 ? 289 THR   A OG1 1 
ATOM   1620 C  CG2 . THR   A 1 289 ? -2.00858  -18.19271 -39.08345 1.000 20.68089 ? 289 THR   A CG2 1 
ATOM   1621 N  N   . LYS   A 1 290 ? 0.22080   -15.66241 -35.52255 1.000 23.98440 ? 290 LYS   A N   1 
ATOM   1622 C  CA  . LYS   A 1 290 ? 0.92420   -14.44476 -35.14804 1.000 28.63341 ? 290 LYS   A CA  1 
ATOM   1623 C  C   . LYS   A 1 290 ? 2.43458   -14.66124 -35.15207 1.000 31.85743 ? 290 LYS   A C   1 
ATOM   1624 O  O   . LYS   A 1 290 ? 2.93564   -15.75053 -34.84826 1.000 28.23757 ? 290 LYS   A O   1 
ATOM   1625 C  CB  . LYS   A 1 290 ? 0.46780   -13.95222 -33.77037 1.000 30.41596 ? 290 LYS   A CB  1 
ATOM   1626 C  CG  . LYS   A 1 290 ? 1.30129   -14.47555 -32.60419 1.000 31.22690 ? 290 LYS   A CG  1 
ATOM   1627 C  CD  . LYS   A 1 290 ? 1.05769   -13.69157 -31.32861 1.000 31.40394 ? 290 LYS   A CD  1 
ATOM   1628 C  CE  . LYS   A 1 290 ? 0.17569   -14.44922 -30.36194 1.000 32.10751 ? 290 LYS   A CE  1 
ATOM   1629 N  NZ  . LYS   A 1 290 ? 0.29799   -13.88935 -28.97054 1.000 28.45231 ? 290 LYS   A NZ  1 
ATOM   1630 N  N   . LYS   A 1 291 ? 3.15366   -13.60396 -35.52141 1.000 28.36887 ? 291 LYS   A N   1 
ATOM   1631 C  CA  . LYS   A 1 291 ? 4.60443   -13.54521 -35.45196 1.000 31.21663 ? 291 LYS   A CA  1 
ATOM   1632 C  C   . LYS   A 1 291 ? 5.02115   -12.50221 -34.42518 1.000 35.48918 ? 291 LYS   A C   1 
ATOM   1633 O  O   . LYS   A 1 291 ? 4.40311   -11.43805 -34.32144 1.000 29.96294 ? 291 LYS   A O   1 
ATOM   1634 C  CB  . LYS   A 1 291 ? 5.20982   -13.18874 -36.81098 1.000 30.24737 ? 291 LYS   A CB  1 
ATOM   1635 C  CG  . LYS   A 1 291 ? 5.00155   -14.22496 -37.88995 1.000 36.76249 ? 291 LYS   A CG  1 
ATOM   1636 C  CD  . LYS   A 1 291 ? 5.66223   -13.77137 -39.18957 1.000 42.64995 ? 291 LYS   A CD  1 
ATOM   1637 C  CE  . LYS   A 1 291 ? 6.62069   -14.83148 -39.74950 1.000 37.70329 ? 291 LYS   A CE  1 
ATOM   1638 N  NZ  . LYS   A 1 291 ? 5.90579   -16.00931 -40.33902 1.000 28.40860 ? 291 LYS   A NZ  1 
ATOM   1639 N  N   . VAL   A 1 292 ? 6.06773   -12.80946 -33.66287 1.000 35.77838 ? 292 VAL   A N   1 
ATOM   1640 C  CA  . VAL   A 1 292 ? 6.65863   -11.84577 -32.74557 1.000 36.96021 ? 292 VAL   A CA  1 
ATOM   1641 C  C   . VAL   A 1 292 ? 8.11990   -11.65317 -33.12667 1.000 42.51331 ? 292 VAL   A C   1 
ATOM   1642 O  O   . VAL   A 1 292 ? 8.71338   -12.46090 -33.84664 1.000 40.54300 ? 292 VAL   A O   1 
ATOM   1643 C  CB  . VAL   A 1 292 ? 6.52952   -12.27160 -31.27080 1.000 38.11147 ? 292 VAL   A CB  1 
ATOM   1644 C  CG1 . VAL   A 1 292 ? 5.08860   -12.64463 -30.95387 1.000 32.56868 ? 292 VAL   A CG1 1 
ATOM   1645 C  CG2 . VAL   A 1 292 ? 7.47551   -13.41726 -30.96705 1.000 42.56765 ? 292 VAL   A CG2 1 
ATOM   1646 N  N   . THR   A 1 293 ? 8.69293   -10.55130 -32.64549 1.000 44.80882 ? 293 THR   A N   1 
ATOM   1647 C  CA  . THR   A 1 293 ? 10.07824  -10.21486 -32.92911 1.000 47.09494 ? 293 THR   A CA  1 
ATOM   1648 C  C   . THR   A 1 293 ? 11.00196  -10.88789 -31.91347 1.000 48.80803 ? 293 THR   A C   1 
ATOM   1649 O  O   . THR   A 1 293 ? 10.56047  -11.56419 -30.97813 1.000 47.44947 ? 293 THR   A O   1 
ATOM   1650 C  CB  . THR   A 1 293 ? 10.28210  -8.69737  -32.92186 1.000 47.05632 ? 293 THR   A CB  1 
ATOM   1651 O  OG1 . THR   A 1 293 ? 10.08326  -8.19111  -31.59494 1.000 48.62260 ? 293 THR   A OG1 1 
ATOM   1652 C  CG2 . THR   A 1 293 ? 9.30976   -8.01314  -33.87749 1.000 42.30518 ? 293 THR   A CG2 1 
ATOM   1653 N  N   . SER   A 1 294 ? 12.31261  -10.69555 -32.10805 1.000 55.61269 ? 294 SER   A N   1 
ATOM   1654 C  CA  . SER   A 1 294 ? 13.30879  -11.17021 -31.15247 1.000 53.99697 ? 294 SER   A CA  1 
ATOM   1655 C  C   . SER   A 1 294 ? 13.19099  -10.47767 -29.79886 1.000 52.06846 ? 294 SER   A C   1 
ATOM   1656 O  O   . SER   A 1 294 ? 13.66824  -11.02090 -28.79662 1.000 55.91241 ? 294 SER   A O   1 
ATOM   1657 C  CB  . SER   A 1 294 ? 14.71270  -10.97433 -31.72584 1.000 51.57659 ? 294 SER   A CB  1 
ATOM   1658 O  OG  . SER   A 1 294 ? 14.84783  -9.69122  -32.31348 1.000 46.56840 ? 294 SER   A OG  1 
ATOM   1659 N  N   . SER   A 1 295 ? 12.56792  -9.29938  -29.74586 1.000 49.86319 ? 295 SER   A N   1 
ATOM   1660 C  CA  . SER   A 1 295 ? 12.25018  -8.64411  -28.48273 1.000 51.27849 ? 295 SER   A CA  1 
ATOM   1661 C  C   . SER   A 1 295 ? 10.91743  -9.10048  -27.88913 1.000 52.12611 ? 295 SER   A C   1 
ATOM   1662 O  O   . SER   A 1 295 ? 10.52373  -8.59180  -26.83459 1.000 50.16197 ? 295 SER   A O   1 
ATOM   1663 C  CB  . SER   A 1 295 ? 12.24233  -7.11984  -28.66160 1.000 51.67710 ? 295 SER   A CB  1 
ATOM   1664 O  OG  . SER   A 1 295 ? 11.12790  -6.69358  -29.42948 1.000 49.86931 ? 295 SER   A OG  1 
ATOM   1665 N  N   . GLY   A 1 296 ? 10.21759  -10.04162 -28.52931 1.000 47.81697 ? 296 GLY   A N   1 
ATOM   1666 C  CA  . GLY   A 1 296 ? 8.98431   -10.57963 -27.97995 1.000 45.32831 ? 296 GLY   A CA  1 
ATOM   1667 C  C   . GLY   A 1 296 ? 7.73817   -9.77840  -28.28887 1.000 43.66963 ? 296 GLY   A C   1 
ATOM   1668 O  O   . GLY   A 1 296 ? 6.68479   -10.03315 -27.69103 1.000 38.33909 ? 296 GLY   A O   1 
ATOM   1669 N  N   . VAL   A 1 297 ? 7.82002   -8.83384  -29.21109 1.000 38.32191 ? 297 VAL   A N   1 
ATOM   1670 C  CA  . VAL   A 1 297 ? 6.74805   -7.88919  -29.47731 1.000 36.43745 ? 297 VAL   A CA  1 
ATOM   1671 C  C   . VAL   A 1 297 ? 6.11433   -8.23859  -30.81680 1.000 37.12837 ? 297 VAL   A C   1 
ATOM   1672 O  O   . VAL   A 1 297 ? 6.76404   -8.81122  -31.70078 1.000 34.69928 ? 297 VAL   A O   1 
ATOM   1673 C  CB  . VAL   A 1 297 ? 7.31053   -6.45013  -29.42800 1.000 36.74851 ? 297 VAL   A CB  1 
ATOM   1674 C  CG1 . VAL   A 1 297 ? 6.80983   -5.62799  -30.55487 1.000 31.09779 ? 297 VAL   A CG1 1 
ATOM   1675 C  CG2 . VAL   A 1 297 ? 6.99449   -5.79250  -28.07991 1.000 28.98446 ? 297 VAL   A CG2 1 
ATOM   1676 N  N   . LEU   A 1 298 ? 4.82207   -7.93019  -30.94961 1.000 28.39753 ? 298 LEU   A N   1 
ATOM   1677 C  CA  . LEU   A 1 298 ? 4.07324   -8.34288  -32.12801 1.000 27.71686 ? 298 LEU   A CA  1 
ATOM   1678 C  C   . LEU   A 1 298 ? 4.69481   -7.76254  -33.39149 1.000 26.19424 ? 298 LEU   A C   1 
ATOM   1679 O  O   . LEU   A 1 298 ? 5.10123   -6.59797  -33.42356 1.000 27.63649 ? 298 LEU   A O   1 
ATOM   1680 C  CB  . LEU   A 1 298 ? 2.61564   -7.90549  -32.00091 1.000 28.59458 ? 298 LEU   A CB  1 
ATOM   1681 C  CG  . LEU   A 1 298 ? 1.60393   -8.82360  -32.66888 1.000 38.14738 ? 298 LEU   A CG  1 
ATOM   1682 C  CD1 . LEU   A 1 298 ? 1.83140   -10.26940 -32.21650 1.000 36.32086 ? 298 LEU   A CD1 1 
ATOM   1683 C  CD2 . LEU   A 1 298 ? 0.18452   -8.35643  -32.34221 1.000 34.92790 ? 298 LEU   A CD2 1 
ATOM   1684 N  N   . LEU   A 1 299 ? 4.77865   -8.58295  -34.43058 1.000 25.83963 ? 299 LEU   A N   1 
ATOM   1685 C  CA  . LEU   A 1 299 ? 5.35744   -8.18542  -35.70772 1.000 25.42129 ? 299 LEU   A CA  1 
ATOM   1686 C  C   . LEU   A 1 299 ? 4.22070   -7.95889  -36.70088 1.000 26.42139 ? 299 LEU   A C   1 
ATOM   1687 O  O   . LEU   A 1 299 ? 3.44849   -8.88452  -36.98313 1.000 24.42801 ? 299 LEU   A O   1 
ATOM   1688 C  CB  . LEU   A 1 299 ? 6.33740   -9.25470  -36.20983 1.000 28.63307 ? 299 LEU   A CB  1 
ATOM   1689 C  CG  . LEU   A 1 299 ? 6.81442   -9.20263  -37.66926 1.000 36.85227 ? 299 LEU   A CG  1 
ATOM   1690 C  CD1 . LEU   A 1 299 ? 7.40051   -7.84574  -38.02333 1.000 37.48172 ? 299 LEU   A CD1 1 
ATOM   1691 C  CD2 . LEU   A 1 299 ? 7.82712   -10.30755 -37.97482 1.000 36.82687 ? 299 LEU   A CD2 1 
ATOM   1692 N  N   . LEU   A 1 300 ? 4.11185   -6.72737  -37.21770 1.000 28.55244 ? 300 LEU   A N   1 
ATOM   1693 C  CA  . LEU   A 1 300 ? 3.03353   -6.33453  -38.12746 1.000 26.57270 ? 300 LEU   A CA  1 
ATOM   1694 C  C   . LEU   A 1 300 ? 3.63773   -5.76248  -39.40631 1.000 28.72405 ? 300 LEU   A C   1 
ATOM   1695 O  O   . LEU   A 1 300 ? 4.05660   -4.60059  -39.43032 1.000 32.51818 ? 300 LEU   A O   1 
ATOM   1696 C  CB  . LEU   A 1 300 ? 2.09482   -5.32156  -37.46526 1.000 25.89736 ? 300 LEU   A CB  1 
ATOM   1697 C  CG  . LEU   A 1 300 ? 1.33267   -5.79690  -36.22985 1.000 23.36282 ? 300 LEU   A CG  1 
ATOM   1698 C  CD1 . LEU   A 1 300 ? 0.44520   -4.67120  -35.66746 1.000 23.14758 ? 300 LEU   A CD1 1 
ATOM   1699 C  CD2 . LEU   A 1 300 ? 0.52682   -7.06677  -36.51904 1.000 21.69336 ? 300 LEU   A CD2 1 
ATOM   1700 N  N   . ASP   A 1 301 ? 3.61044   -6.56478  -40.48205 1.000 29.14935 ? 301 ASP   A N   1 
ATOM   1701 C  CA  . ASP   A 1 301 ? 4.37146   -6.33578  -41.71457 1.000 35.77091 ? 301 ASP   A CA  1 
ATOM   1702 C  C   . ASP   A 1 301 ? 3.79140   -5.25049  -42.59995 1.000 31.73533 ? 301 ASP   A C   1 
ATOM   1703 O  O   . ASP   A 1 301 ? 4.52276   -4.65778  -43.39357 1.000 35.07342 ? 301 ASP   A O   1 
ATOM   1704 C  CB  . ASP   A 1 301 ? 4.40549   -7.61078  -42.56711 1.000 25.90328 ? 301 ASP   A CB  1 
ATOM   1705 C  CG  . ASP   A 1 301 ? 5.67324   -8.38498  -42.41134 1.000 39.86730 ? 301 ASP   A CG  1 
ATOM   1706 O  OD1 . ASP   A 1 301 ? 6.23004   -8.39651  -41.29433 1.000 49.51508 ? 301 ASP   A OD1 1 
ATOM   1707 O  OD2 . ASP   A 1 301 ? 6.10520   -9.00476  -43.40945 1.000 48.72121 ? 301 ASP   A OD2 1 
ATOM   1708 N  N   . ASN   A 1 302 ? 2.48422   -5.03058  -42.53758 1.000 27.37389 ? 302 ASN   A N   1 
ATOM   1709 C  CA  . ASN   A 1 302 ? 1.77106   -4.39143  -43.62920 1.000 25.41633 ? 302 ASN   A CA  1 
ATOM   1710 C  C   . ASN   A 1 302 ? 0.57192   -3.64430  -43.07094 1.000 25.48440 ? 302 ASN   A C   1 
ATOM   1711 O  O   . ASN   A 1 302 ? 0.12430   -3.90809  -41.95033 1.000 21.88351 ? 302 ASN   A O   1 
ATOM   1712 C  CB  . ASN   A 1 302 ? 1.29993   -5.43109  -44.64883 1.000 26.27255 ? 302 ASN   A CB  1 
ATOM   1713 C  CG  . ASN   A 1 302 ? 0.49298   -6.54163  -43.99884 1.000 27.67258 ? 302 ASN   A CG  1 
ATOM   1714 O  OD1 . ASN   A 1 302 ? -0.67783  -6.35361  -43.63885 1.000 21.94229 ? 302 ASN   A OD1 1 
ATOM   1715 N  ND2 . ASN   A 1 302 ? 1.11963   -7.70451  -43.82467 1.000 31.28202 ? 302 ASN   A ND2 1 
ATOM   1716 N  N   . TYR   A 1 303 ? 0.03361   -2.73234  -43.88766 1.000 23.67837 ? 303 TYR   A N   1 
ATOM   1717 C  CA  . TYR   A 1 303 ? -1.10665  -1.92752  -43.45127 1.000 27.24501 ? 303 TYR   A CA  1 
ATOM   1718 C  C   . TYR   A 1 303 ? -2.25196  -2.80899  -42.97003 1.000 23.09148 ? 303 TYR   A C   1 
ATOM   1719 O  O   . TYR   A 1 303 ? -2.82297  -2.57346  -41.89663 1.000 23.02068 ? 303 TYR   A O   1 
ATOM   1720 C  CB  . TYR   A 1 303 ? -1.59576  -1.00943  -44.57429 1.000 22.93343 ? 303 TYR   A CB  1 
ATOM   1721 C  CG  . TYR   A 1 303 ? -2.73096  -0.12311  -44.08950 1.000 21.81672 ? 303 TYR   A CG  1 
ATOM   1722 C  CD1 . TYR   A 1 303 ? -2.48632  0.92232   -43.19510 1.000 19.91040 ? 303 TYR   A CD1 1 
ATOM   1723 C  CD2 . TYR   A 1 303 ? -4.04723  -0.35513  -44.48090 1.000 18.52374 ? 303 TYR   A CD2 1 
ATOM   1724 C  CE1 . TYR   A 1 303 ? -3.52425  1.72363   -42.71474 1.000 18.58324 ? 303 TYR   A CE1 1 
ATOM   1725 C  CE2 . TYR   A 1 303 ? -5.09167  0.45385   -44.01705 1.000 20.42392 ? 303 TYR   A CE2 1 
ATOM   1726 C  CZ  . TYR   A 1 303 ? -4.82425  1.48878   -43.13325 1.000 18.14799 ? 303 TYR   A CZ  1 
ATOM   1727 O  OH  . TYR   A 1 303 ? -5.85756  2.29084   -42.66537 1.000 16.46643 ? 303 TYR   A OH  1 
ATOM   1728 N  N   . SER   A 1 304 ? -2.58049  -3.84512  -43.74958 1.000 16.58747 ? 304 SER   A N   1 
ATOM   1729 C  CA  . SER   A 1 304 ? -3.73536  -4.68503  -43.45393 1.000 16.79358 ? 304 SER   A CA  1 
ATOM   1730 C  C   . SER   A 1 304 ? -3.68228  -5.25713  -42.03507 1.000 22.42349 ? 304 SER   A C   1 
ATOM   1731 O  O   . SER   A 1 304 ? -4.69487  -5.26179  -41.32889 1.000 17.87605 ? 304 SER   A O   1 
ATOM   1732 C  CB  . SER   A 1 304 ? -3.84426  -5.80605  -44.48563 1.000 20.40838 ? 304 SER   A CB  1 
ATOM   1733 O  OG  . SER   A 1 304 ? -4.84248  -6.73211  -44.09379 1.000 29.77854 ? 304 SER   A OG  1 
ATOM   1734 N  N   . ASP   A 1 305 ? -2.51240  -5.75169  -41.60240 1.000 19.92298 ? 305 ASP   A N   1 
ATOM   1735 C  CA  . ASP   A 1 305 ? -2.37580  -6.28252  -40.24592 1.000 20.82447 ? 305 ASP   A CA  1 
ATOM   1736 C  C   . ASP   A 1 305 ? -2.35392  -5.16562  -39.20385 1.000 20.79327 ? 305 ASP   A C   1 
ATOM   1737 O  O   . ASP   A 1 305 ? -2.93114  -5.30869  -38.11483 1.000 15.11866 ? 305 ASP   A O   1 
ATOM   1738 C  CB  . ASP   A 1 305 ? -1.09606  -7.11424  -40.11674 1.000 19.94276 ? 305 ASP   A CB  1 
ATOM   1739 C  CG  . ASP   A 1 305 ? -1.20486  -8.47799  -40.77756 1.000 24.67420 ? 305 ASP   A CG  1 
ATOM   1740 O  OD1 . ASP   A 1 305 ? -2.33299  -8.98442  -40.97109 1.000 22.51737 ? 305 ASP   A OD1 1 
ATOM   1741 O  OD2 . ASP   A 1 305 ? -0.14622  -9.04050  -41.10226 1.000 27.13532 ? 305 ASP   A OD2 1 
ATOM   1742 N  N   . ARG   A 1 306 ? -1.66699  -4.06356  -39.50461 1.000 15.78444 ? 306 ARG   A N   1 
ATOM   1743 C  CA  . ARG   A 1 306 ? -1.59954  -2.96109  -38.55155 1.000 19.37424 ? 306 ARG   A CA  1 
ATOM   1744 C  C   . ARG   A 1 306 ? -2.98460  -2.35935  -38.30874 1.000 14.15927 ? 306 ARG   A C   1 
ATOM   1745 O  O   . ARG   A 1 306 ? -3.39510  -2.16474  -37.15678 1.000 13.48177 ? 306 ARG   A O   1 
ATOM   1746 C  CB  . ARG   A 1 306 ? -0.60463  -1.90817  -39.04961 1.000 21.64799 ? 306 ARG   A CB  1 
ATOM   1747 C  CG  . ARG   A 1 306 ? 0.83798   -2.43407  -39.21719 1.000 20.10587 ? 306 ARG   A CG  1 
ATOM   1748 C  CD  . ARG   A 1 306 ? 1.74228   -1.42159  -39.89838 1.000 22.39466 ? 306 ARG   A CD  1 
ATOM   1749 N  NE  . ARG   A 1 306 ? 2.18121   -0.37397  -38.98113 1.000 21.43008 ? 306 ARG   A NE  1 
ATOM   1750 C  CZ  . ARG   A 1 306 ? 3.22379   -0.49743  -38.15886 1.000 22.93512 ? 306 ARG   A CZ  1 
ATOM   1751 N  NH1 . ARG   A 1 306 ? 3.92583   -1.62817  -38.13548 1.000 24.70910 ? 306 ARG   A NH1 1 
ATOM   1752 N  NH2 . ARG   A 1 306 ? 3.56207   0.49572   -37.34860 1.000 21.05522 ? 306 ARG   A NH2 1 
ATOM   1753 N  N   . ILE   A 1 307 ? -3.73638  -2.08824  -39.37770 1.000 17.01516 ? 307 ILE   A N   1 
ATOM   1754 C  CA  . ILE   A 1 307 ? -5.04763  -1.46598  -39.17787 1.000 17.48206 ? 307 ILE   A CA  1 
ATOM   1755 C  C   . ILE   A 1 307 ? -5.99238  -2.45885  -38.50861 1.000 15.66653 ? 307 ILE   A C   1 
ATOM   1756 O  O   . ILE   A 1 307 ? -6.80901  -2.07462  -37.66051 1.000 13.31631 ? 307 ILE   A O   1 
ATOM   1757 C  CB  . ILE   A 1 307 ? -5.60612  -0.89902  -40.51064 1.000 15.10928 ? 307 ILE   A CB  1 
ATOM   1758 C  CG1 . ILE   A 1 307 ? -6.71165  0.14847   -40.25528 1.000 13.62109 ? 307 ILE   A CG1 1 
ATOM   1759 C  CG2 . ILE   A 1 307 ? -6.12279  -2.01260  -41.43420 1.000 17.19033 ? 307 ILE   A CG2 1 
ATOM   1760 C  CD1 . ILE   A 1 307 ? -6.25497  1.35065   -39.39083 1.000 14.22808 ? 307 ILE   A CD1 1 
ATOM   1761 N  N   . GLN   A 1 308 ? -5.83705  -3.75860  -38.80081 1.000 14.33220 ? 308 GLN   A N   1 
ATOM   1762 C  CA  . GLN   A 1 308 ? -6.68577  -4.76270  -38.16830 1.000 14.66754 ? 308 GLN   A CA  1 
ATOM   1763 C  C   . GLN   A 1 308 ? -6.52852  -4.74542  -36.64979 1.000 13.44872 ? 308 GLN   A C   1 
ATOM   1764 O  O   . GLN   A 1 308 ? -7.52008  -4.79791  -35.90972 1.000 10.96137 ? 308 GLN   A O   1 
ATOM   1765 C  CB  . GLN   A 1 308 ? -6.35426  -6.14832  -38.73718 1.000 19.05364 ? 308 GLN   A CB  1 
ATOM   1766 C  CG  . GLN   A 1 308 ? -7.13893  -7.26096  -38.11149 1.000 19.19803 ? 308 GLN   A CG  1 
ATOM   1767 C  CD  . GLN   A 1 308 ? -6.82784  -8.62958  -38.71516 1.000 28.71654 ? 308 GLN   A CD  1 
ATOM   1768 O  OE1 . GLN   A 1 308 ? -6.00647  -8.77133  -39.63917 1.000 25.43926 ? 308 GLN   A OE1 1 
ATOM   1769 N  NE2 . GLN   A 1 308 ? -7.50090  -9.65154  -38.19311 1.000 30.54723 ? 308 GLN   A NE2 1 
ATOM   1770 N  N   . VAL   A 1 309 ? -5.28748  -4.65353  -36.16979 1.000 12.03333 ? 309 VAL   A N   1 
ATOM   1771 C  CA  . VAL   A 1 309 ? -5.02598  -4.57470  -34.73533 1.000 12.98609 ? 309 VAL   A CA  1 
ATOM   1772 C  C   . VAL   A 1 309 ? -5.59205  -3.28586  -34.13788 1.000 11.56973 ? 309 VAL   A C   1 
ATOM   1773 O  O   . VAL   A 1 309 ? -6.17020  -3.30205  -33.04456 1.000 13.47941 ? 309 VAL   A O   1 
ATOM   1774 C  CB  . VAL   A 1 309 ? -3.51163  -4.69867  -34.46920 1.000 11.11503 ? 309 VAL   A CB  1 
ATOM   1775 C  CG1 . VAL   A 1 309 ? -3.20075  -4.38117  -33.02061 1.000 10.89200 ? 309 VAL   A CG1 1 
ATOM   1776 C  CG2 . VAL   A 1 309 ? -3.04198  -6.12025  -34.81424 1.000 18.30775 ? 309 VAL   A CG2 1 
ATOM   1777 N  N   . LEU   A 1 310 ? -5.42498  -2.15339  -34.82327 1.000 11.36287 ? 310 LEU   A N   1 
ATOM   1778 C  CA  . LEU   A 1 310 ? -5.98476  -0.90797  -34.29619 1.000 9.15635  ? 310 LEU   A CA  1 
ATOM   1779 C  C   . LEU   A 1 310 ? -7.51673  -0.92131  -34.34753 1.000 10.63892 ? 310 LEU   A C   1 
ATOM   1780 O  O   . LEU   A 1 310 ? -8.18273  -0.37242  -33.45785 1.000 10.45095 ? 310 LEU   A O   1 
ATOM   1781 C  CB  . LEU   A 1 310 ? -5.41720  0.28805   -35.06339 1.000 12.34729 ? 310 LEU   A CB  1 
ATOM   1782 C  CG  . LEU   A 1 310 ? -3.88845  0.49969   -34.95433 1.000 12.40215 ? 310 LEU   A CG  1 
ATOM   1783 C  CD1 . LEU   A 1 310 ? -3.43268  1.54986   -35.97800 1.000 14.28298 ? 310 LEU   A CD1 1 
ATOM   1784 C  CD2 . LEU   A 1 310 ? -3.44168  0.89465   -33.54454 1.000 11.69293 ? 310 LEU   A CD2 1 
ATOM   1785 N  N   . GLN   A 1 311 ? -8.09041  -1.55517  -35.36898 1.000 9.16253  ? 311 GLN   A N   1 
ATOM   1786 C  CA  . GLN   A 1 311 ? -9.54234  -1.69472  -35.43669 1.000 12.26826 ? 311 GLN   A CA  1 
ATOM   1787 C  C   . GLN   A 1 311 ? -10.07694 -2.49610  -34.25672 1.000 13.10333 ? 311 GLN   A C   1 
ATOM   1788 O  O   . GLN   A 1 311 ? -11.05164 -2.09438  -33.60631 1.000 11.73700 ? 311 GLN   A O   1 
ATOM   1789 C  CB  . GLN   A 1 311 ? -9.94542  -2.35891  -36.74722 1.000 12.32468 ? 311 GLN   A CB  1 
ATOM   1790 C  CG  . GLN   A 1 311 ? -9.84309  -1.46163  -37.98024 1.000 9.58075  ? 311 GLN   A CG  1 
ATOM   1791 C  CD  . GLN   A 1 311 ? -10.09399 -2.25838  -39.24507 1.000 15.09913 ? 311 GLN   A CD  1 
ATOM   1792 O  OE1 . GLN   A 1 311 ? -9.62831  -3.39296  -39.36506 1.000 14.59624 ? 311 GLN   A OE1 1 
ATOM   1793 N  NE2 . GLN   A 1 311 ? -10.84154 -1.68300  -40.18647 1.000 12.82742 ? 311 GLN   A NE2 1 
ATOM   1794 N  N   . ASN   A 1 312 ? -9.44233  -3.63524  -33.96250 1.000 13.76168 ? 312 ASN   A N   1 
ATOM   1795 C  CA  . ASN   A 1 312 ? -9.86753  -4.46279  -32.84148 1.000 11.92565 ? 312 ASN   A CA  1 
ATOM   1796 C  C   . ASN   A 1 312 ? -9.52346  -3.81794  -31.50575 1.000 10.13268 ? 312 ASN   A C   1 
ATOM   1797 O  O   . ASN   A 1 312 ? -10.24544 -4.01277  -30.52114 1.000 9.59817  ? 312 ASN   A O   1 
ATOM   1798 C  CB  . ASN   A 1 312 ? -9.23219  -5.85276  -32.95684 1.000 13.10106 ? 312 ASN   A CB  1 
ATOM   1799 C  CG  . ASN   A 1 312 ? -9.96415  -6.73845  -33.95018 1.000 15.86458 ? 312 ASN   A CG  1 
ATOM   1800 O  OD1 . ASN   A 1 312 ? -10.98370 -7.33171  -33.62746 1.000 18.56198 ? 312 ASN   A OD1 1 
ATOM   1801 N  ND2 . ASN   A 1 312 ? -9.46271  -6.80511  -35.16068 1.000 14.40113 ? 312 ASN   A ND2 1 
ATOM   1802 N  N   . MET   A 1 313 ? -8.44346  -3.02953  -31.45573 1.000 10.97562 ? 313 MET   A N   1 
ATOM   1803 C  CA  . MET   A 1 313 ? -8.09843  -2.34671  -30.21475 1.000 13.67438 ? 313 MET   A CA  1 
ATOM   1804 C  C   . MET   A 1 313 ? -9.20421  -1.38396  -29.80144 1.000 12.05046 ? 313 MET   A C   1 
ATOM   1805 O  O   . MET   A 1 313 ? -9.63431  -1.37465  -28.64237 1.000 10.78464 ? 313 MET   A O   1 
ATOM   1806 C  CB  . MET   A 1 313 ? -6.77623  -1.59602  -30.36288 1.000 10.15367 ? 313 MET   A CB  1 
ATOM   1807 C  CG  . MET   A 1 313 ? -6.32117  -0.96136  -29.06899 1.000 12.79166 ? 313 MET   A CG  1 
ATOM   1808 S  SD  . MET   A 1 313 ? -4.87678  0.11060   -29.26545 1.000 13.88798 ? 313 MET   A SD  1 
ATOM   1809 C  CE  . MET   A 1 313 ? -3.65063  -1.07953  -29.80261 1.000 14.58865 ? 313 MET   A CE  1 
ATOM   1810 N  N   . VAL   A 1 314 ? -9.67607  -0.56248  -30.74376 1.000 8.91907  ? 314 VAL   A N   1 
ATOM   1811 C  CA  . VAL   A 1 314 ? -10.70211 0.42722   -30.41311 1.000 10.50616 ? 314 VAL   A CA  1 
ATOM   1812 C  C   . VAL   A 1 314 ? -12.05246 -0.25344  -30.19113 1.000 9.75270  ? 314 VAL   A C   1 
ATOM   1813 O  O   . VAL   A 1 314 ? -12.84269 0.15447   -29.32736 1.000 8.97839  ? 314 VAL   A O   1 
ATOM   1814 C  CB  . VAL   A 1 314 ? -10.74829 1.50638   -31.51291 1.000 8.92168  ? 314 VAL   A CB  1 
ATOM   1815 C  CG1 . VAL   A 1 314 ? -11.85190 2.52751   -31.24838 1.000 10.15668 ? 314 VAL   A CG1 1 
ATOM   1816 C  CG2 . VAL   A 1 314 ? -9.41029  2.23295   -31.57351 1.000 7.80027  ? 314 VAL   A CG2 1 
ATOM   1817 N  N   . HIS   A 1 315 ? -12.31053 -1.33587  -30.93193 1.000 12.82388 ? 315 HIS   A N   1 
ATOM   1818 C  CA  . HIS   A 1 315 ? -13.51124 -2.13967  -30.71344 1.000 10.95057 ? 315 HIS   A CA  1 
ATOM   1819 C  C   . HIS   A 1 315 ? -13.53147 -2.73841  -29.30292 1.000 11.31032 ? 315 HIS   A C   1 
ATOM   1820 O  O   . HIS   A 1 315 ? -14.56801 -2.70761  -28.62165 1.000 11.34184 ? 315 HIS   A O   1 
ATOM   1821 C  CB  . HIS   A 1 315 ? -13.57183 -3.21911  -31.80628 1.000 9.55843  ? 315 HIS   A CB  1 
ATOM   1822 C  CG  . HIS   A 1 315 ? -14.78705 -4.09254  -31.76397 1.000 11.28623 ? 315 HIS   A CG  1 
ATOM   1823 N  ND1 . HIS   A 1 315 ? -16.06978 -3.59724  -31.66760 1.000 12.88926 ? 315 HIS   A ND1 1 
ATOM   1824 C  CD2 . HIS   A 1 315 ? -14.91065 -5.43968  -31.86899 1.000 10.79604 ? 315 HIS   A CD2 1 
ATOM   1825 C  CE1 . HIS   A 1 315 ? -16.93044 -4.60400  -31.67553 1.000 16.20890 ? 315 HIS   A CE1 1 
ATOM   1826 N  NE2 . HIS   A 1 315 ? -16.24992 -5.73322  -31.79767 1.000 12.54043 ? 315 HIS   A NE2 1 
ATOM   1827 N  N   . CYS   A 1 316 ? -12.38976 -3.27406  -28.84019 1.000 9.32896  ? 316 CYS   A N   1 
ATOM   1828 C  CA  . CYS   A 1 316 ? -12.27829 -3.75773  -27.45957 1.000 9.11819  ? 316 CYS   A CA  1 
ATOM   1829 C  C   . CYS   A 1 316 ? -12.51856 -2.64117  -26.45589 1.000 11.26843 ? 316 CYS   A C   1 
ATOM   1830 O  O   . CYS   A 1 316 ? -13.16988 -2.84938  -25.42604 1.000 10.54044 ? 316 CYS   A O   1 
ATOM   1831 C  CB  . CYS   A 1 316 ? -10.88746 -4.35892  -27.20050 1.000 10.60913 ? 316 CYS   A CB  1 
ATOM   1832 S  SG  . CYS   A 1 316 ? -10.61748 -6.01051  -27.88610 1.000 12.92849 ? 316 CYS   A SG  1 
ATOM   1833 N  N   . ALA   A 1 317 ? -11.93830 -1.46707  -26.70248 1.000 8.78993  ? 317 ALA   A N   1 
ATOM   1834 C  CA  . ALA   A 1 317 ? -12.15299 -0.34214  -25.79314 1.000 8.92738  ? 317 ALA   A CA  1 
ATOM   1835 C  C   . ALA   A 1 317 ? -13.62751 0.04382   -25.75340 1.000 9.21771  ? 317 ALA   A C   1 
ATOM   1836 O  O   . ALA   A 1 317 ? -14.17701 0.34275   -24.68720 1.000 8.64796  ? 317 ALA   A O   1 
ATOM   1837 C  CB  . ALA   A 1 317 ? -11.28724 0.84390   -26.22886 1.000 8.43534  ? 317 ALA   A CB  1 
ATOM   1838 N  N   . ASP   A 1 318 ? -14.28235 0.01713   -26.91415 1.000 10.96420 ? 318 ASP   A N   1 
ATOM   1839 C  CA  . ASP   A 1 318 ? -15.71669 0.28884   -27.00152 1.000 9.47595  ? 318 ASP   A CA  1 
ATOM   1840 C  C   . ASP   A 1 318 ? -16.52291 -0.73660  -26.20366 1.000 12.28411 ? 318 ASP   A C   1 
ATOM   1841 O  O   . ASP   A 1 318 ? -17.55249 -0.40747  -25.60248 1.000 10.12892 ? 318 ASP   A O   1 
ATOM   1842 C  CB  . ASP   A 1 318 ? -16.11438 0.27908   -28.47977 1.000 10.52085 ? 318 ASP   A CB  1 
ATOM   1843 C  CG  . ASP   A 1 318 ? -17.43616 0.97867   -28.76632 1.000 11.00916 ? 318 ASP   A CG  1 
ATOM   1844 O  OD1 . ASP   A 1 318 ? -17.81523 1.92699   -28.05411 1.000 9.45793  ? 318 ASP   A OD1 1 
ATOM   1845 O  OD2 . ASP   A 1 318 ? -18.09267 0.57405   -29.73880 1.000 13.53890 ? 318 ASP   A OD2 1 
ATOM   1846 N  N   . LEU   A 1 319 ? -16.07960 -1.99081  -26.20498 1.000 10.65149 ? 319 LEU   A N   1 
ATOM   1847 C  CA  . LEU   A 1 319 ? -16.73219 -3.06909  -25.46628 1.000 10.60917 ? 319 LEU   A CA  1 
ATOM   1848 C  C   . LEU   A 1 319 ? -15.98733 -3.40079  -24.18363 1.000 12.47519 ? 319 LEU   A C   1 
ATOM   1849 O  O   . LEU   A 1 319 ? -15.92460 -4.57296  -23.78163 1.000 13.45656 ? 319 LEU   A O   1 
ATOM   1850 C  CB  . LEU   A 1 319 ? -16.86431 -4.31348  -26.34202 1.000 8.20596  ? 319 LEU   A CB  1 
ATOM   1851 C  CG  . LEU   A 1 319 ? -17.65551 -4.10371  -27.62731 1.000 17.96761 ? 319 LEU   A CG  1 
ATOM   1852 C  CD1 . LEU   A 1 319 ? -17.70238 -5.38791  -28.45870 1.000 16.55836 ? 319 LEU   A CD1 1 
ATOM   1853 C  CD2 . LEU   A 1 319 ? -19.06688 -3.58441  -27.32316 1.000 17.12384 ? 319 LEU   A CD2 1 
ATOM   1854 N  N   . SER   A 1 320 ? -15.42206 -2.39196  -23.50817 1.000 10.74965 ? 320 SER   A N   1 
ATOM   1855 C  CA  . SER   A 1 320 ? -14.63930 -2.64309  -22.30540 1.000 10.40804 ? 320 SER   A CA  1 
ATOM   1856 C  C   . SER   A 1 320 ? -15.42281 -2.52051  -21.00484 1.000 11.13079 ? 320 SER   A C   1 
ATOM   1857 O  O   . SER   A 1 320 ? -14.88128 -2.90435  -19.96232 1.000 10.68518 ? 320 SER   A O   1 
ATOM   1858 C  CB  . SER   A 1 320 ? -13.39001 -1.72510  -22.26329 1.000 15.52076 ? 320 SER   A CB  1 
ATOM   1859 O  OG  . SER   A 1 320 ? -13.68101 -0.34423  -22.08416 1.000 12.69381 ? 320 SER   A OG  1 
ATOM   1860 N  N   . ASN   A 1 321 ? -16.68107 -2.03742  -21.02512 1.000 13.71080 ? 321 ASN   A N   1 
ATOM   1861 C  CA  . ASN   A 1 321 ? -17.40698 -1.82048  -19.77158 1.000 9.73336  ? 321 ASN   A CA  1 
ATOM   1862 C  C   . ASN   A 1 321 ? -17.41675 -3.05993  -18.88284 1.000 12.25398 ? 321 ASN   A C   1 
ATOM   1863 O  O   . ASN   A 1 321 ? -17.10651 -2.92659  -17.68962 1.000 10.31995 ? 321 ASN   A O   1 
ATOM   1864 C  CB  . ASN   A 1 321 ? -18.86152 -1.36584  -19.99914 1.000 8.40839  ? 321 ASN   A CB  1 
ATOM   1865 C  CG  . ASN   A 1 321 ? -18.97300 -0.05321  -20.75972 1.000 12.67716 ? 321 ASN   A CG  1 
ATOM   1866 O  OD1 . ASN   A 1 321 ? -20.02313 0.23596   -21.32469 1.000 12.40349 ? 321 ASN   A OD1 1 
ATOM   1867 N  ND2 . ASN   A 1 321 ? -17.89454 0.73659   -20.79202 1.000 10.39818 ? 321 ASN   A ND2 1 
ATOM   1868 N  N   . PRO   A 1 322 ? -17.73436 -4.27040  -19.37696 1.000 12.06191 ? 322 PRO   A N   1 
ATOM   1869 C  CA  . PRO   A 1 322 ? -17.75941 -5.44139  -18.47920 1.000 11.71652 ? 322 PRO   A CA  1 
ATOM   1870 C  C   . PRO   A 1 322 ? -16.38801 -5.85823  -17.96336 1.000 10.12748 ? 322 PRO   A C   1 
ATOM   1871 O  O   . PRO   A 1 322 ? -16.32163 -6.68548  -17.04822 1.000 11.61712 ? 322 PRO   A O   1 
ATOM   1872 C  CB  . PRO   A 1 322 ? -18.40165 -6.54570  -19.34697 1.000 13.03205 ? 322 PRO   A CB  1 
ATOM   1873 C  CG  . PRO   A 1 322 ? -19.14835 -5.80574  -20.42617 1.000 11.98892 ? 322 PRO   A CG  1 
ATOM   1874 C  CD  . PRO   A 1 322 ? -18.24101 -4.62251  -20.71755 1.000 8.10022  ? 322 PRO   A CD  1 
ATOM   1875 N  N   . THR   A 1 323 ? -15.29695 -5.30003  -18.48420 1.000 10.51329 ? 323 THR   A N   1 
ATOM   1876 C  CA  . THR   A 1 323 ? -13.98538 -5.62912  -17.95563 1.000 11.32602 ? 323 THR   A CA  1 
ATOM   1877 C  C   . THR   A 1 323 ? -13.54585 -4.69230  -16.83882 1.000 12.22830 ? 323 THR   A C   1 
ATOM   1878 O  O   . THR   A 1 323 ? -12.49808 -4.92672  -16.23240 1.000 13.98497 ? 323 THR   A O   1 
ATOM   1879 C  CB  . THR   A 1 323 ? -12.94172 -5.61601  -19.07326 1.000 10.79664 ? 323 THR   A CB  1 
ATOM   1880 O  OG1 . THR   A 1 323 ? -12.59555 -4.26105  -19.38179 1.000 10.53052 ? 323 THR   A OG1 1 
ATOM   1881 C  CG2 . THR   A 1 323 ? -13.47546 -6.31971  -20.33845 1.000 10.70840 ? 323 THR   A CG2 1 
ATOM   1882 N  N   . LYS   A 1 324 ? -14.30609 -3.64195  -16.56190 1.000 11.18512 ? 324 LYS   A N   1 
ATOM   1883 C  CA  . LYS   A 1 324 ? -13.92333 -2.63155  -15.59292 1.000 13.68377 ? 324 LYS   A CA  1 
ATOM   1884 C  C   . LYS   A 1 324 ? -14.36210 -3.04025  -14.19488 1.000 11.88724 ? 324 LYS   A C   1 
ATOM   1885 O  O   . LYS   A 1 324 ? -15.28281 -3.84731  -14.04362 1.000 12.14400 ? 324 LYS   A O   1 
ATOM   1886 C  CB  . LYS   A 1 324 ? -14.55314 -1.28790  -15.96587 1.000 8.10792  ? 324 LYS   A CB  1 
ATOM   1887 C  CG  . LYS   A 1 324 ? -14.04752 -0.72151  -17.28685 1.000 9.83415  ? 324 LYS   A CG  1 
ATOM   1888 C  CD  . LYS   A 1 324 ? -12.55682 -0.34698  -17.16425 1.000 12.04660 ? 324 LYS   A CD  1 
ATOM   1889 C  CE  . LYS   A 1 324 ? -11.96096 0.07128   -18.51432 1.000 11.73633 ? 324 LYS   A CE  1 
ATOM   1890 N  NZ  . LYS   A 1 324 ? -12.47640 1.37996   -19.05516 1.000 11.13545 ? 324 LYS   A NZ  1 
ATOM   1891 N  N   . PRO   A 1 325 ? -13.72550 -2.48693  -13.15343 1.000 11.50381 ? 325 PRO   A N   1 
ATOM   1892 C  CA  . PRO   A 1 325 ? -14.20680 -2.70391  -11.78067 1.000 14.29271 ? 325 PRO   A CA  1 
ATOM   1893 C  C   . PRO   A 1 325 ? -15.71795 -2.56146  -11.69125 1.000 15.76031 ? 325 PRO   A C   1 
ATOM   1894 O  O   . PRO   A 1 325 ? -16.31514 -1.71200  -12.35188 1.000 13.24007 ? 325 PRO   A O   1 
ATOM   1895 C  CB  . PRO   A 1 325 ? -13.49644 -1.60704  -10.98182 1.000 15.18207 ? 325 PRO   A CB  1 
ATOM   1896 C  CG  . PRO   A 1 325 ? -12.23572 -1.38499  -11.70969 1.000 13.96434 ? 325 PRO   A CG  1 
ATOM   1897 C  CD  . PRO   A 1 325 ? -12.56246 -1.58377  -13.18317 1.000 11.29661 ? 325 PRO   A CD  1 
ATOM   1898 N  N   . LEU   A 1 326 ? -16.32746 -3.39163  -10.83731 1.000 13.92600 ? 326 LEU   A N   1 
ATOM   1899 C  CA  . LEU   A 1 326 ? -17.76803 -3.61567  -10.90216 1.000 14.91547 ? 326 LEU   A CA  1 
ATOM   1900 C  C   . LEU   A 1 326 ? -18.56943 -2.33059  -10.70694 1.000 16.69554 ? 326 LEU   A C   1 
ATOM   1901 O  O   . LEU   A 1 326 ? -19.62756 -2.16569  -11.32412 1.000 16.20017 ? 326 LEU   A O   1 
ATOM   1902 C  CB  . LEU   A 1 326 ? -18.17626 -4.65495  -9.86206  1.000 14.10951 ? 326 LEU   A CB  1 
ATOM   1903 C  CG  . LEU   A 1 326 ? -19.66951 -4.99996  -9.82407  1.000 16.44141 ? 326 LEU   A CG  1 
ATOM   1904 C  CD1 . LEU   A 1 326 ? -20.09229 -5.62147  -11.13307 1.000 11.47673 ? 326 LEU   A CD1 1 
ATOM   1905 C  CD2 . LEU   A 1 326 ? -19.96994 -5.93976  -8.67085  1.000 17.60118 ? 326 LEU   A CD2 1 
ATOM   1906 N  N   . GLN   A 1 327 ? -18.09833 -1.41594  -9.84987  1.000 14.46412 ? 327 GLN   A N   1 
ATOM   1907 C  CA  . GLN   A 1 327 ? -18.86088 -0.19112  -9.63965  1.000 14.66556 ? 327 GLN   A CA  1 
ATOM   1908 C  C   . GLN   A 1 327 ? -18.87498 0.68715   -10.89135 1.000 14.11892 ? 327 GLN   A C   1 
ATOM   1909 O  O   . GLN   A 1 327 ? -19.82476 1.45690   -11.08590 1.000 18.56117 ? 327 GLN   A O   1 
ATOM   1910 C  CB  . GLN   A 1 327 ? -18.32632 0.57252   -8.42385  1.000 14.48979 ? 327 GLN   A CB  1 
ATOM   1911 C  CG  . GLN   A 1 327 ? -17.14837 1.49535   -8.67081  1.000 16.81004 ? 327 GLN   A CG  1 
ATOM   1912 C  CD  . GLN   A 1 327 ? -15.82653 0.77671   -8.91605  1.000 19.48985 ? 327 GLN   A CD  1 
ATOM   1913 O  OE1 . GLN   A 1 327 ? -15.70278 -0.44460  -8.73979  1.000 17.83030 ? 327 GLN   A OE1 1 
ATOM   1914 N  NE2 . GLN   A 1 327 ? -14.82601 1.54160   -9.34786  1.000 19.69000 ? 327 GLN   A NE2 1 
ATOM   1915 N  N   . LEU   A 1 328 ? -17.85614 0.58867   -11.75110 1.000 13.07893 ? 328 LEU   A N   1 
ATOM   1916 C  CA  . LEU   A 1 328 ? -17.92038 1.26934   -13.04779 1.000 13.68512 ? 328 LEU   A CA  1 
ATOM   1917 C  C   . LEU   A 1 328 ? -18.84729 0.51974   -13.99950 1.000 15.69406 ? 328 LEU   A C   1 
ATOM   1918 O  O   . LEU   A 1 328 ? -19.75198 1.11133   -14.60466 1.000 11.68127 ? 328 LEU   A O   1 
ATOM   1919 C  CB  . LEU   A 1 328 ? -16.51003 1.41038   -13.65140 1.000 13.91141 ? 328 LEU   A CB  1 
ATOM   1920 C  CG  . LEU   A 1 328 ? -15.52590 2.34171   -12.89385 1.000 16.04783 ? 328 LEU   A CG  1 
ATOM   1921 C  CD1 . LEU   A 1 328 ? -14.10563 2.35719   -13.46692 1.000 13.73930 ? 328 LEU   A CD1 1 
ATOM   1922 C  CD2 . LEU   A 1 328 ? -16.05633 3.77662   -12.77533 1.000 17.52203 ? 328 LEU   A CD2 1 
ATOM   1923 N  N   . TYR   A 1 329 ? -18.62570 -0.79245  -14.13078 1.000 12.07662 ? 329 TYR   A N   1 
ATOM   1924 C  CA  . TYR   A 1 329 ? -19.43666 -1.62673  -15.00968 1.000 11.48023 ? 329 TYR   A CA  1 
ATOM   1925 C  C   . TYR   A 1 329 ? -20.92404 -1.43168  -14.73777 1.000 12.92005 ? 329 TYR   A C   1 
ATOM   1926 O  O   . TYR   A 1 329 ? -21.71181 -1.21268  -15.66371 1.000 12.70826 ? 329 TYR   A O   1 
ATOM   1927 C  CB  . TYR   A 1 329 ? -19.01787 -3.09199  -14.82225 1.000 12.40084 ? 329 TYR   A CB  1 
ATOM   1928 C  CG  . TYR   A 1 329 ? -19.76734 -4.12363  -15.63940 1.000 12.03657 ? 329 TYR   A CG  1 
ATOM   1929 C  CD1 . TYR   A 1 329 ? -20.53494 -3.77337  -16.75227 1.000 10.37599 ? 329 TYR   A CD1 1 
ATOM   1930 C  CD2 . TYR   A 1 329 ? -19.70861 -5.46703  -15.28074 1.000 10.95829 ? 329 TYR   A CD2 1 
ATOM   1931 C  CE1 . TYR   A 1 329 ? -21.22798 -4.74063  -17.47648 1.000 9.60914  ? 329 TYR   A CE1 1 
ATOM   1932 C  CE2 . TYR   A 1 329 ? -20.36855 -6.42380  -16.00237 1.000 10.12586 ? 329 TYR   A CE2 1 
ATOM   1933 C  CZ  . TYR   A 1 329 ? -21.13594 -6.06029  -17.09036 1.000 13.20089 ? 329 TYR   A CZ  1 
ATOM   1934 O  OH  . TYR   A 1 329 ? -21.81216 -7.04725  -17.77564 1.000 12.73310 ? 329 TYR   A OH  1 
ATOM   1935 N  N   . ARG   A 1 330 ? -21.32775 -1.47970  -13.46786 1.000 12.21012 ? 330 ARG   A N   1 
ATOM   1936 C  CA  . ARG   A 1 330 ? -22.75552 -1.35563  -13.15931 1.000 12.71432 ? 330 ARG   A CA  1 
ATOM   1937 C  C   . ARG   A 1 330 ? -23.31406 0.00710   -13.57364 1.000 14.08930 ? 330 ARG   A C   1 
ATOM   1938 O  O   . ARG   A 1 330 ? -24.46213 0.10931   -14.02557 1.000 13.81809 ? 330 ARG   A O   1 
ATOM   1939 C  CB  . ARG   A 1 330 ? -22.98777 -1.60839  -11.66770 1.000 14.28651 ? 330 ARG   A CB  1 
ATOM   1940 C  CG  . ARG   A 1 330 ? -23.08769 -3.10034  -11.31501 1.000 15.65947 ? 330 ARG   A CG  1 
ATOM   1941 C  CD  . ARG   A 1 330 ? -23.53596 -3.28640  -9.85209  1.000 19.85085 ? 330 ARG   A CD  1 
ATOM   1942 N  NE  . ARG   A 1 330 ? -24.96942 -3.06165  -9.68823  1.000 30.51053 ? 330 ARG   A NE  1 
ATOM   1943 C  CZ  . ARG   A 1 330 ? -25.62334 -3.05804  -8.52681  1.000 23.32774 ? 330 ARG   A CZ  1 
ATOM   1944 N  NH1 . ARG   A 1 330 ? -24.99107 -3.28040  -7.38297  1.000 20.80182 ? 330 ARG   A NH1 1 
ATOM   1945 N  NH2 . ARG   A 1 330 ? -26.92688 -2.82956  -8.52679  1.000 29.87325 ? 330 ARG   A NH2 1 
ATOM   1946 N  N   . GLN   A 1 331 ? -22.52933 1.07347   -13.43185 1.000 12.69668 ? 331 GLN   A N   1 
ATOM   1947 C  CA  . GLN   A 1 331 ? -23.05026 2.35964   -13.87994 1.000 14.57491 ? 331 GLN   A CA  1 
ATOM   1948 C  C   . GLN   A 1 331 ? -23.21731 2.39610   -15.40714 1.000 13.93997 ? 331 GLN   A C   1 
ATOM   1949 O  O   . GLN   A 1 331 ? -24.19850 2.96437   -15.90990 1.000 11.42316 ? 331 GLN   A O   1 
ATOM   1950 C  CB  . GLN   A 1 331 ? -22.14729 3.48895   -13.36511 1.000 15.17868 ? 331 GLN   A CB  1 
ATOM   1951 C  CG  . GLN   A 1 331 ? -22.44338 4.87241   -13.95906 1.000 18.10117 ? 331 GLN   A CG  1 
ATOM   1952 C  CD  . GLN   A 1 331 ? -23.71606 5.57025   -13.43821 1.000 24.85846 ? 331 GLN   A CD  1 
ATOM   1953 O  OE1 . GLN   A 1 331 ? -24.05545 6.67444   -13.90584 1.000 19.56029 ? 331 GLN   A OE1 1 
ATOM   1954 N  NE2 . GLN   A 1 331 ? -24.41868 4.93766   -12.48197 1.000 22.41784 ? 331 GLN   A NE2 1 
ATOM   1955 N  N   . TRP   A 1 332 ? -22.29745 1.77789   -16.15522 1.000 10.58315 ? 332 TRP   A N   1 
ATOM   1956 C  CA  . TRP   A 1 332 ? -22.46863 1.67855   -17.60388 1.000 10.62577 ? 332 TRP   A CA  1 
ATOM   1957 C  C   . TRP   A 1 332 ? -23.72376 0.89102   -17.95698 1.000 11.61893 ? 332 TRP   A C   1 
ATOM   1958 O  O   . TRP   A 1 332 ? -24.43581 1.24412   -18.89885 1.000 12.62673 ? 332 TRP   A O   1 
ATOM   1959 C  CB  . TRP   A 1 332 ? -21.23645 1.03661   -18.25683 1.000 8.08492  ? 332 TRP   A CB  1 
ATOM   1960 C  CG  . TRP   A 1 332 ? -20.02663 1.92235   -18.23555 1.000 10.33188 ? 332 TRP   A CG  1 
ATOM   1961 C  CD1 . TRP   A 1 332 ? -18.82667 1.66519   -17.63610 1.000 11.64830 ? 332 TRP   A CD1 1 
ATOM   1962 C  CD2 . TRP   A 1 332 ? -19.91226 3.22872   -18.81755 1.000 10.77705 ? 332 TRP   A CD2 1 
ATOM   1963 N  NE1 . TRP   A 1 332 ? -17.97541 2.73968   -17.80627 1.000 11.77907 ? 332 TRP   A NE1 1 
ATOM   1964 C  CE2 . TRP   A 1 332 ? -18.61933 3.70641   -18.52995 1.000 9.03742  ? 332 TRP   A CE2 1 
ATOM   1965 C  CE3 . TRP   A 1 332 ? -20.78830 4.04751   -19.54101 1.000 9.61159  ? 332 TRP   A CE3 1 
ATOM   1966 C  CZ2 . TRP   A 1 332 ? -18.16767 4.95595   -18.96046 1.000 11.78551 ? 332 TRP   A CZ2 1 
ATOM   1967 C  CZ3 . TRP   A 1 332 ? -20.33656 5.29447   -19.96857 1.000 11.03858 ? 332 TRP   A CZ3 1 
ATOM   1968 C  CH2 . TRP   A 1 332 ? -19.03741 5.73261   -19.67642 1.000 10.91423 ? 332 TRP   A CH2 1 
ATOM   1969 N  N   . THR   A 1 333 ? -24.01315 -0.17838  -17.21426 1.000 13.46897 ? 333 THR   A N   1 
ATOM   1970 C  CA  . THR   A 1 333 ? -25.19984 -0.98421  -17.51392 1.000 12.98501 ? 333 THR   A CA  1 
ATOM   1971 C  C   . THR   A 1 333 ? -26.48775 -0.20714  -17.23802 1.000 13.16713 ? 333 THR   A C   1 
ATOM   1972 O  O   . THR   A 1 333 ? -27.42905 -0.24734  -18.03983 1.000 12.22242 ? 333 THR   A O   1 
ATOM   1973 C  CB  . THR   A 1 333 ? -25.16130 -2.28282  -16.69958 1.000 12.79720 ? 333 THR   A CB  1 
ATOM   1974 O  OG1 . THR   A 1 333 ? -23.99257 -3.04234  -17.04215 1.000 12.78304 ? 333 THR   A OG1 1 
ATOM   1975 C  CG2 . THR   A 1 333 ? -26.40306 -3.12179  -16.96710 1.000 14.99349 ? 333 THR   A CG2 1 
ATOM   1976 N  N   . ASP   A 1 334 ? -26.55042 0.49760   -16.10400 1.000 17.02581 ? 334 ASP   A N   1 
ATOM   1977 C  CA  . ASP   A 1 334 ? -27.67324 1.39523   -15.84411 1.000 13.29823 ? 334 ASP   A CA  1 
ATOM   1978 C  C   . ASP   A 1 334 ? -27.90479 2.34721   -17.01193 1.000 15.57201 ? 334 ASP   A C   1 
ATOM   1979 O  O   . ASP   A 1 334 ? -29.05070 2.58287   -17.41792 1.000 16.27586 ? 334 ASP   A O   1 
ATOM   1980 C  CB  . ASP   A 1 334 ? -27.42425 2.21462   -14.57390 1.000 14.51866 ? 334 ASP   A CB  1 
ATOM   1981 C  CG  . ASP   A 1 334 ? -27.38907 1.37443   -13.31814 1.000 20.16005 ? 334 ASP   A CG  1 
ATOM   1982 O  OD1 . ASP   A 1 334 ? -27.77213 0.18231   -13.35121 1.000 18.57569 ? 334 ASP   A OD1 1 
ATOM   1983 O  OD2 . ASP   A 1 334 ? -26.96441 1.92831   -12.28415 1.000 22.27748 ? 334 ASP   A OD2 1 
ATOM   1984 N  N   . ARG   A 1 335 ? -26.82862 2.92106   -17.55598 1.000 12.04158 ? 335 ARG   A N   1 
ATOM   1985 C  CA  . ARG   A 1 335 ? -26.98645 3.90346   -18.62614 1.000 13.03731 ? 335 ARG   A CA  1 
ATOM   1986 C  C   . ARG   A 1 335 ? -27.42059 3.27154   -19.94748 1.000 13.66084 ? 335 ARG   A C   1 
ATOM   1987 O  O   . ARG   A 1 335 ? -28.29329 3.82369   -20.63320 1.000 13.36064 ? 335 ARG   A O   1 
ATOM   1988 C  CB  . ARG   A 1 335 ? -25.69037 4.69609   -18.80034 1.000 11.89262 ? 335 ARG   A CB  1 
ATOM   1989 C  CG  . ARG   A 1 335 ? -25.47454 5.72786   -17.66613 1.000 12.13646 ? 335 ARG   A CG  1 
ATOM   1990 C  CD  . ARG   A 1 335 ? -24.01631 6.22393   -17.64048 1.000 13.66273 ? 335 ARG   A CD  1 
ATOM   1991 N  NE  . ARG   A 1 335 ? -23.80524 7.28873   -16.66388 1.000 12.72098 ? 335 ARG   A NE  1 
ATOM   1992 C  CZ  . ARG   A 1 335 ? -24.09568 8.56931   -16.89379 1.000 17.08628 ? 335 ARG   A CZ  1 
ATOM   1993 N  NH1 . ARG   A 1 335 ? -24.59660 8.92983   -18.07340 1.000 14.72060 ? 335 ARG   A NH1 1 
ATOM   1994 N  NH2 . ARG   A 1 335 ? -23.88262 9.49355   -15.95609 1.000 13.51044 ? 335 ARG   A NH2 1 
ATOM   1995 N  N   . ILE   A 1 336 ? -26.81313 2.14569   -20.35037 1.000 13.88449 ? 336 ILE   A N   1 
ATOM   1996 C  CA  . ILE   A 1 336 ? -27.22957 1.55037   -21.62407 1.000 12.89594 ? 336 ILE   A CA  1 
ATOM   1997 C  C   . ILE   A 1 336 ? -28.68372 1.09484   -21.54389 1.000 14.55854 ? 336 ILE   A C   1 
ATOM   1998 O  O   . ILE   A 1 336 ? -29.43040 1.21028   -22.52636 1.000 13.55766 ? 336 ILE   A O   1 
ATOM   1999 C  CB  . ILE   A 1 336 ? -26.29767 0.39409   -22.06270 1.000 15.94248 ? 336 ILE   A CB  1 
ATOM   2000 C  CG1 . ILE   A 1 336 ? -26.53874 0.03514   -23.53571 1.000 14.42077 ? 336 ILE   A CG1 1 
ATOM   2001 C  CG2 . ILE   A 1 336 ? -26.50633 -0.88171  -21.23350 1.000 15.71175 ? 336 ILE   A CG2 1 
ATOM   2002 C  CD1 . ILE   A 1 336 ? -26.10864 1.09598   -24.51177 1.000 13.40095 ? 336 ILE   A CD1 1 
ATOM   2003 N  N   . MET   A 1 337 ? -29.12127 0.60811   -20.37654 1.000 14.15385 ? 337 MET   A N   1 
ATOM   2004 C  CA  . MET   A 1 337 ? -30.50399 0.14120   -20.24145 1.000 16.55818 ? 337 MET   A CA  1 
ATOM   2005 C  C   . MET   A 1 337 ? -31.49633 1.29743   -20.32378 1.000 17.64908 ? 337 MET   A C   1 
ATOM   2006 O  O   . MET   A 1 337 ? -32.55712 1.16756   -20.94628 1.000 18.77967 ? 337 MET   A O   1 
ATOM   2007 C  CB  . MET   A 1 337 ? -30.67891 -0.63792  -18.93332 1.000 14.42885 ? 337 MET   A CB  1 
ATOM   2008 C  CG  . MET   A 1 337 ? -29.96907 -2.00050  -18.92229 1.000 15.63307 ? 337 MET   A CG  1 
ATOM   2009 S  SD  . MET   A 1 337 ? -30.17054 -2.99567  -20.43629 1.000 26.07051 ? 337 MET   A SD  1 
ATOM   2010 C  CE  . MET   A 1 337 ? -31.95655 -3.14970  -20.58113 1.000 23.51363 ? 337 MET   A CE  1 
ATOM   2011 N  N   . GLU   A 1 338 ? -31.16372 2.44408   -19.72327 1.000 15.96605 ? 338 GLU   A N   1 
ATOM   2012 C  CA  . GLU   A 1 338 ? -32.02416 3.61108   -19.85895 1.000 18.20854 ? 338 GLU   A CA  1 
ATOM   2013 C  C   . GLU   A 1 338 ? -32.12830 4.05552   -21.31513 1.000 23.24395 ? 338 GLU   A C   1 
ATOM   2014 O  O   . GLU   A 1 338 ? -33.20697 4.43900   -21.78779 1.000 19.47087 ? 338 GLU   A O   1 
ATOM   2015 C  CB  . GLU   A 1 338 ? -31.49044 4.74198   -18.99440 1.000 21.60760 ? 338 GLU   A CB  1 
ATOM   2016 C  CG  . GLU   A 1 338 ? -32.30809 6.00889   -19.09829 1.000 26.46243 ? 338 GLU   A CG  1 
ATOM   2017 C  CD  . GLU   A 1 338 ? -31.67823 7.11550   -18.30319 1.000 40.73773 ? 338 GLU   A CD  1 
ATOM   2018 O  OE1 . GLU   A 1 338 ? -31.07940 6.80796   -17.24352 1.000 47.44176 ? 338 GLU   A OE1 1 
ATOM   2019 O  OE2 . GLU   A 1 338 ? -31.76124 8.28344   -18.74141 1.000 53.09668 ? 338 GLU   A OE2 1 
ATOM   2020 N  N   . GLU   A 1 339 ? -31.01559 4.00266   -22.04377 1.000 20.62067 ? 339 GLU   A N   1 
ATOM   2021 C  CA  . GLU   A 1 339 ? -31.03809 4.34911   -23.45926 1.000 19.16769 ? 339 GLU   A CA  1 
ATOM   2022 C  C   . GLU   A 1 339 ? -31.88639 3.36149   -24.24324 1.000 19.38191 ? 339 GLU   A C   1 
ATOM   2023 O  O   . GLU   A 1 339 ? -32.74294 3.77009   -25.03471 1.000 20.32872 ? 339 GLU   A O   1 
ATOM   2024 C  CB  . GLU   A 1 339 ? -29.60452 4.39880   -24.00143 1.000 20.84977 ? 339 GLU   A CB  1 
ATOM   2025 C  CG  . GLU   A 1 339 ? -29.44563 5.21826   -25.27399 1.000 17.76876 ? 339 GLU   A CG  1 
ATOM   2026 C  CD  . GLU   A 1 339 ? -27.99360 5.41573   -25.68283 1.000 16.18100 ? 339 GLU   A CD  1 
ATOM   2027 O  OE1 . GLU   A 1 339 ? -27.21791 6.03589   -24.91321 1.000 16.11221 ? 339 GLU   A OE1 1 
ATOM   2028 O  OE2 . GLU   A 1 339 ? -27.64037 4.96201   -26.79130 1.000 16.73658 ? 339 GLU   A OE2 1 
ATOM   2029 N  N   . PHE   A 1 340 ? -31.67554 2.05800   -24.01771 1.000 16.51009 ? 340 PHE   A N   1 
ATOM   2030 C  CA  . PHE   A 1 340 ? -32.48891 1.03539   -24.66988 1.000 20.43844 ? 340 PHE   A CA  1 
ATOM   2031 C  C   . PHE   A 1 340 ? -33.96865 1.22881   -24.35811 1.000 26.77967 ? 340 PHE   A C   1 
ATOM   2032 O  O   . PHE   A 1 340 ? -34.81113 1.20139   -25.26355 1.000 26.08050 ? 340 PHE   A O   1 
ATOM   2033 C  CB  . PHE   A 1 340 ? -32.04242 -0.36473  -24.23991 1.000 20.73093 ? 340 PHE   A CB  1 
ATOM   2034 C  CG  . PHE   A 1 340 ? -30.84702 -0.89203  -24.99193 1.000 23.46290 ? 340 PHE   A CG  1 
ATOM   2035 C  CD1 . PHE   A 1 340 ? -29.98371 -0.03282  -25.65927 1.000 20.91412 ? 340 PHE   A CD1 1 
ATOM   2036 C  CD2 . PHE   A 1 340 ? -30.58302 -2.25448  -25.02779 1.000 27.25045 ? 340 PHE   A CD2 1 
ATOM   2037 C  CE1 . PHE   A 1 340 ? -28.88895 -0.53002  -26.35010 1.000 21.38804 ? 340 PHE   A CE1 1 
ATOM   2038 C  CE2 . PHE   A 1 340 ? -29.48644 -2.74678  -25.71230 1.000 25.39008 ? 340 PHE   A CE2 1 
ATOM   2039 C  CZ  . PHE   A 1 340 ? -28.64355 -1.88075  -26.37400 1.000 24.04592 ? 340 PHE   A CZ  1 
ATOM   2040 N  N   . PHE   A 1 341 ? -34.30498 1.42418   -23.07430 1.000 24.70947 ? 341 PHE   A N   1 
ATOM   2041 C  CA  . PHE   A 1 341 ? -35.71187 1.55882   -22.69289 1.000 27.38160 ? 341 PHE   A CA  1 
ATOM   2042 C  C   . PHE   A 1 341 ? -36.34689 2.76183   -23.36678 1.000 26.66049 ? 341 PHE   A C   1 
ATOM   2043 O  O   . PHE   A 1 341 ? -37.49119 2.69380   -23.83081 1.000 28.73823 ? 341 PHE   A O   1 
ATOM   2044 C  CB  . PHE   A 1 341 ? -35.84553 1.67536   -21.17627 1.000 21.33648 ? 341 PHE   A CB  1 
ATOM   2045 C  CG  . PHE   A 1 341 ? -35.52647 0.40292   -20.44774 1.000 21.33330 ? 341 PHE   A CG  1 
ATOM   2046 C  CD1 . PHE   A 1 341 ? -35.65141 -0.82000  -21.08343 1.000 22.10149 ? 341 PHE   A CD1 1 
ATOM   2047 C  CD2 . PHE   A 1 341 ? -35.11328 0.42678   -19.12579 1.000 24.69218 ? 341 PHE   A CD2 1 
ATOM   2048 C  CE1 . PHE   A 1 341 ? -35.35894 -1.98950  -20.42621 1.000 25.67648 ? 341 PHE   A CE1 1 
ATOM   2049 C  CE2 . PHE   A 1 341 ? -34.81224 -0.75565  -18.45624 1.000 22.51216 ? 341 PHE   A CE2 1 
ATOM   2050 C  CZ  . PHE   A 1 341 ? -34.93751 -1.95808  -19.10604 1.000 24.49498 ? 341 PHE   A CZ  1 
ATOM   2051 N  N   . ARG   A 1 342 ? -35.60817 3.86696   -23.43987 1.000 24.02230 ? 342 ARG   A N   1 
ATOM   2052 C  CA  . ARG   A 1 342 ? -36.08960 5.07074   -24.09583 1.000 27.69354 ? 342 ARG   A CA  1 
ATOM   2053 C  C   . ARG   A 1 342 ? -36.26715 4.89574   -25.60140 1.000 30.09261 ? 342 ARG   A C   1 
ATOM   2054 O  O   . ARG   A 1 342 ? -37.10652 5.58482   -26.19266 1.000 34.64938 ? 342 ARG   A O   1 
ATOM   2055 C  CB  . ARG   A 1 342 ? -35.13441 6.21796   -23.80337 1.000 27.58576 ? 342 ARG   A CB  1 
ATOM   2056 C  CG  . ARG   A 1 342 ? -35.26341 6.76238   -22.39310 1.000 31.26586 ? 342 ARG   A CG  1 
ATOM   2057 C  CD  . ARG   A 1 342 ? -34.86857 8.21056   -22.35587 1.000 41.60244 ? 342 ARG   A CD  1 
ATOM   2058 N  NE  . ARG   A 1 342 ? -35.88130 9.02208   -21.67983 1.000 49.69641 ? 342 ARG   A NE  1 
ATOM   2059 C  CZ  . ARG   A 1 342 ? -36.13015 10.31064  -21.94253 1.000 53.20630 ? 342 ARG   A CZ  1 
ATOM   2060 N  NH1 . ARG   A 1 342 ? -37.08029 10.94849  -21.26629 1.000 49.20796 ? 342 ARG   A NH1 1 
ATOM   2061 N  NH2 . ARG   A 1 342 ? -35.43466 10.94855  -22.89368 1.000 54.78264 ? 342 ARG   A NH2 1 
ATOM   2062 N  N   . GLN   A 1 343 ? -35.49762 4.00873   -26.24075 1.000 27.62575 ? 343 GLN   A N   1 
ATOM   2063 C  CA  . GLN   A 1 343 ? -35.76781 3.70088   -27.64248 1.000 29.38901 ? 343 GLN   A CA  1 
ATOM   2064 C  C   . GLN   A 1 343 ? -36.98159 2.79244   -27.76606 1.000 32.43395 ? 343 GLN   A C   1 
ATOM   2065 O  O   . GLN   A 1 343 ? -37.79013 2.95461   -28.68491 1.000 28.83121 ? 343 GLN   A O   1 
ATOM   2066 C  CB  . GLN   A 1 343 ? -34.55163 3.04979   -28.30820 1.000 22.53122 ? 343 GLN   A CB  1 
ATOM   2067 C  CG  . GLN   A 1 343 ? -34.83297 2.49102   -29.70772 1.000 22.58146 ? 343 GLN   A CG  1 
ATOM   2068 C  CD  . GLN   A 1 343 ? -33.65512 1.70161   -30.29036 1.000 22.71604 ? 343 GLN   A CD  1 
ATOM   2069 O  OE1 . GLN   A 1 343 ? -32.50162 2.13073   -30.21723 1.000 18.40716 ? 343 GLN   A OE1 1 
ATOM   2070 N  NE2 . GLN   A 1 343 ? -33.94431 0.52028   -30.82819 1.000 20.18830 ? 343 GLN   A NE2 1 
ATOM   2071 N  N   . GLY   A 1 344 ? -37.12479 1.83726   -26.84272 1.000 28.06372 ? 344 GLY   A N   1 
ATOM   2072 C  CA  . GLY   A 1 344 ? -38.28940 0.97005   -26.86015 1.000 35.56747 ? 344 GLY   A CA  1 
ATOM   2073 C  C   . GLY   A 1 344 ? -39.58936 1.71474   -26.62771 1.000 35.66424 ? 344 GLY   A C   1 
ATOM   2074 O  O   . GLY   A 1 344 ? -40.63287 1.32802   -27.16072 1.000 42.48169 ? 344 GLY   A O   1 
ATOM   2075 N  N   . ASP   A 1 345 ? -39.54760 2.78593   -25.83200 1.000 35.14157 ? 345 ASP   A N   1 
ATOM   2076 C  CA  . ASP   A 1 345 ? -40.71978 3.63950   -25.67151 1.000 36.63097 ? 345 ASP   A CA  1 
ATOM   2077 C  C   . ASP   A 1 345 ? -41.15568 4.21663   -27.01439 1.000 42.76755 ? 345 ASP   A C   1 
ATOM   2078 O  O   . ASP   A 1 345 ? -42.32609 4.10976   -27.39775 1.000 49.07728 ? 345 ASP   A O   1 
ATOM   2079 C  CB  . ASP   A 1 345 ? -40.42289 4.76087   -24.67413 1.000 34.70086 ? 345 ASP   A CB  1 
ATOM   2080 C  CG  . ASP   A 1 345 ? -40.37945 4.28166   -23.21512 1.000 30.10875 ? 345 ASP   A CG  1 
ATOM   2081 O  OD1 . ASP   A 1 345 ? -40.48281 3.06264   -22.93697 1.000 28.99180 ? 345 ASP   A OD1 1 
ATOM   2082 O  OD2 . ASP   A 1 345 ? -40.22305 5.15643   -22.34098 1.000 26.50846 ? 345 ASP   A OD2 1 
ATOM   2083 N  N   . ARG   A 1 346 ? -40.21918 4.82230   -27.75162 1.000 37.04068 ? 346 ARG   A N   1 
ATOM   2084 C  CA  . ARG   A 1 346 ? -40.52666 5.32704   -29.09092 1.000 40.46305 ? 346 ARG   A CA  1 
ATOM   2085 C  C   . ARG   A 1 346 ? -41.07780 4.23356   -29.99558 1.000 42.67124 ? 346 ARG   A C   1 
ATOM   2086 O  O   . ARG   A 1 346 ? -42.04612 4.45380   -30.73369 1.000 50.73825 ? 346 ARG   A O   1 
ATOM   2087 C  CB  . ARG   A 1 346 ? -39.27688 5.92889   -29.72550 1.000 36.53073 ? 346 ARG   A CB  1 
ATOM   2088 C  CG  . ARG   A 1 346 ? -38.92282 7.29034   -29.21172 1.000 36.89209 ? 346 ARG   A CG  1 
ATOM   2089 C  CD  . ARG   A 1 346 ? -37.44727 7.49696   -29.27851 1.000 36.07176 ? 346 ARG   A CD  1 
ATOM   2090 N  NE  . ARG   A 1 346 ? -37.02525 8.26188   -30.45099 1.000 38.29887 ? 346 ARG   A NE  1 
ATOM   2091 C  CZ  . ARG   A 1 346 ? -35.81270 8.80513   -30.58268 1.000 40.39223 ? 346 ARG   A CZ  1 
ATOM   2092 N  NH1 . ARG   A 1 346 ? -34.91817 8.66462   -29.60190 1.000 37.60378 ? 346 ARG   A NH1 1 
ATOM   2093 N  NH2 . ARG   A 1 346 ? -35.50172 9.48897   -31.67718 1.000 39.94081 ? 346 ARG   A NH2 1 
ATOM   2094 N  N   . GLU   A 1 347 ? -40.45957 3.05243   -29.96973 1.000 39.28170 ? 347 GLU   A N   1 
ATOM   2095 C  CA  . GLU   A 1 347 ? -40.92901 1.95337   -30.80453 1.000 41.97831 ? 347 GLU   A CA  1 
ATOM   2096 C  C   . GLU   A 1 347 ? -42.34249 1.52492   -30.41809 1.000 50.78485 ? 347 GLU   A C   1 
ATOM   2097 O  O   . GLU   A 1 347 ? -43.21683 1.39183   -31.28461 1.000 51.08750 ? 347 GLU   A O   1 
ATOM   2098 C  CB  . GLU   A 1 347 ? -39.97253 0.77360   -30.69957 1.000 36.89186 ? 347 GLU   A CB  1 
ATOM   2099 C  CG  . GLU   A 1 347 ? -38.58627 1.01878   -31.25268 1.000 35.83010 ? 347 GLU   A CG  1 
ATOM   2100 C  CD  . GLU   A 1 347 ? -37.68042 -0.14918  -30.95930 1.000 33.25076 ? 347 GLU   A CD  1 
ATOM   2101 O  OE1 . GLU   A 1 347 ? -37.97179 -0.86968  -29.97779 1.000 35.85014 ? 347 GLU   A OE1 1 
ATOM   2102 O  OE2 . GLU   A 1 347 ? -36.70438 -0.37220  -31.71421 1.000 29.34822 ? 347 GLU   A OE2 1 
ATOM   2103 N  N   . ARG   A 1 348 ? -42.58117 1.28650   -29.11948 1.000 47.73738 ? 348 ARG   A N   1 
ATOM   2104 C  CA  . ARG   A 1 348 ? -43.89671 0.82351   -28.67946 1.000 52.14851 ? 348 ARG   A CA  1 
ATOM   2105 C  C   . ARG   A 1 348 ? -44.97691 1.84252   -29.01631 1.000 48.20077 ? 348 ARG   A C   1 
ATOM   2106 O  O   . ARG   A 1 348 ? -46.10802 1.46456   -29.34655 1.000 49.80360 ? 348 ARG   A O   1 
ATOM   2107 C  CB  . ARG   A 1 348 ? -43.88059 0.51551   -27.17420 1.000 50.00988 ? 348 ARG   A CB  1 
ATOM   2108 C  CG  . ARG   A 1 348 ? -45.18649 -0.08091  -26.61183 1.000 51.06954 ? 348 ARG   A CG  1 
ATOM   2109 C  CD  . ARG   A 1 348 ? -45.04825 -0.50730  -25.14333 1.000 44.74386 ? 348 ARG   A CD  1 
ATOM   2110 N  NE  . ARG   A 1 348 ? -44.21715 0.43327   -24.39974 1.000 49.70432 ? 348 ARG   A NE  1 
ATOM   2111 C  CZ  . ARG   A 1 348 ? -43.07497 0.12189   -23.79442 1.000 43.03939 ? 348 ARG   A CZ  1 
ATOM   2112 N  NH1 . ARG   A 1 348 ? -42.62167 -1.12500  -23.80552 1.000 45.07504 ? 348 ARG   A NH1 1 
ATOM   2113 N  NH2 . ARG   A 1 348 ? -42.39101 1.06396   -23.16232 1.000 42.56115 ? 348 ARG   A NH2 1 
ATOM   2114 N  N   . GLU   A 1 349 ? -44.63811 3.13215   -28.95896 1.000 49.14005 ? 349 GLU   A N   1 
ATOM   2115 C  CA  . GLU   A 1 349 ? -45.54399 4.16934   -29.43830 1.000 45.73630 ? 349 GLU   A CA  1 
ATOM   2116 C  C   . GLU   A 1 349 ? -45.95691 3.92017   -30.88513 1.000 52.94689 ? 349 GLU   A C   1 
ATOM   2117 O  O   . GLU   A 1 349 ? -47.14840 3.87604   -31.20608 1.000 54.71368 ? 349 GLU   A O   1 
ATOM   2118 C  CB  . GLU   A 1 349 ? -44.87437 5.53194   -29.31695 1.000 45.44571 ? 349 GLU   A CB  1 
ATOM   2119 C  CG  . GLU   A 1 349 ? -45.24311 6.31922   -28.09650 1.000 48.58018 ? 349 GLU   A CG  1 
ATOM   2120 C  CD  . GLU   A 1 349 ? -44.87341 7.77039   -28.26310 1.000 55.10538 ? 349 GLU   A CD  1 
ATOM   2121 O  OE1 . GLU   A 1 349 ? -45.78715 8.62632   -28.28835 1.000 55.40926 ? 349 GLU   A OE1 1 
ATOM   2122 O  OE2 . GLU   A 1 349 ? -43.66314 8.05013   -28.40236 1.000 53.98045 ? 349 GLU   A OE2 1 
ATOM   2123 N  N   . ARG   A 1 350 ? -44.98163 3.75340   -31.77338 1.000 50.18597 ? 350 ARG   A N   1 
ATOM   2124 C  CA  . ARG   A 1 350 ? -45.22388 3.65034   -33.20694 1.000 49.10032 ? 350 ARG   A CA  1 
ATOM   2125 C  C   . ARG   A 1 350 ? -45.81348 2.30434   -33.63410 1.000 49.62790 ? 350 ARG   A C   1 
ATOM   2126 O  O   . ARG   A 1 350 ? -45.86040 2.02228   -34.83802 1.000 46.71576 ? 350 ARG   A O   1 
ATOM   2127 C  CB  . ARG   A 1 350 ? -43.92080 3.89265   -33.97276 1.000 44.58570 ? 350 ARG   A CB  1 
ATOM   2128 C  CG  . ARG   A 1 350 ? -43.26200 5.23330   -33.72879 1.000 40.13314 ? 350 ARG   A CG  1 
ATOM   2129 C  CD  . ARG   A 1 350 ? -41.86283 5.21695   -34.33245 1.000 44.06455 ? 350 ARG   A CD  1 
ATOM   2130 N  NE  . ARG   A 1 350 ? -41.21139 6.51875   -34.28300 1.000 43.12987 ? 350 ARG   A NE  1 
ATOM   2131 C  CZ  . ARG   A 1 350 ? -40.97155 7.27750   -35.34726 1.000 40.75932 ? 350 ARG   A CZ  1 
ATOM   2132 N  NH1 . ARG   A 1 350 ? -41.31981 6.85465   -36.55574 1.000 33.00391 ? 350 ARG   A NH1 1 
ATOM   2133 N  NH2 . ARG   A 1 350 ? -40.36904 8.45388   -35.20106 1.000 33.19256 ? 350 ARG   A NH2 1 
ATOM   2134 N  N   . GLY   A 1 351 ? -46.24348 1.45777   -32.70480 1.000 45.30359 ? 351 GLY   A N   1 
ATOM   2135 C  CA  . GLY   A 1 351 ? -46.77760 0.16793   -33.09965 1.000 40.32622 ? 351 GLY   A CA  1 
ATOM   2136 C  C   . GLY   A 1 351 ? -45.71832 -0.74564  -33.67684 1.000 50.28549 ? 351 GLY   A C   1 
ATOM   2137 O  O   . GLY   A 1 351 ? -46.02788 -1.82168  -34.19763 1.000 51.94457 ? 351 GLY   A O   1 
ATOM   2138 N  N   . MET   A 1 352 ? -44.46016 -0.31375  -33.60296 1.000 47.24194 ? 352 MET   A N   1 
ATOM   2139 C  CA  . MET   A 1 352 ? -43.35241 -1.17370  -33.97401 1.000 47.74445 ? 352 MET   A CA  1 
ATOM   2140 C  C   . MET   A 1 352 ? -43.11947 -2.20592  -32.87936 1.000 45.20326 ? 352 MET   A C   1 
ATOM   2141 O  O   . MET   A 1 352 ? -43.35772 -1.95259  -31.69504 1.000 49.18853 ? 352 MET   A O   1 
ATOM   2142 C  CB  . MET   A 1 352 ? -42.07783 -0.35188  -34.19390 1.000 45.64037 ? 352 MET   A CB  1 
ATOM   2143 C  CG  . MET   A 1 352 ? -42.23509 0.87574   -35.09131 1.000 47.86240 ? 352 MET   A CG  1 
ATOM   2144 S  SD  . MET   A 1 352 ? -40.79495 1.98024   -35.07537 1.000 43.66388 ? 352 MET   A SD  1 
ATOM   2145 C  CE  . MET   A 1 352 ? -39.50368 0.82540   -35.54079 1.000 30.58122 ? 352 MET   A CE  1 
ATOM   2146 N  N   . GLU   A 1 353 ? -42.66374 -3.38501  -33.28486 1.000 43.62874 ? 353 GLU   A N   1 
ATOM   2147 C  CA  . GLU   A 1 353 ? -42.19597 -4.36209  -32.31499 1.000 47.04711 ? 353 GLU   A CA  1 
ATOM   2148 C  C   . GLU   A 1 353 ? -40.96104 -3.83224  -31.59741 1.000 50.67428 ? 353 GLU   A C   1 
ATOM   2149 O  O   . GLU   A 1 353 ? -39.98455 -3.42109  -32.23274 1.000 45.55711 ? 353 GLU   A O   1 
ATOM   2150 C  CB  . GLU   A 1 353 ? -41.88604 -5.68701  -33.00273 1.000 47.96327 ? 353 GLU   A CB  1 
ATOM   2151 C  CG  . GLU   A 1 353 ? -42.93406 -6.09914  -34.00013 1.000 58.25503 ? 353 GLU   A CG  1 
ATOM   2152 C  CD  . GLU   A 1 353 ? -42.37254 -6.99667  -35.08279 1.000 64.99312 ? 353 GLU   A CD  1 
ATOM   2153 O  OE1 . GLU   A 1 353 ? -42.37386 -6.57655  -36.26699 1.000 67.09579 ? 353 GLU   A OE1 1 
ATOM   2154 O  OE2 . GLU   A 1 353 ? -41.92115 -8.12258  -34.75278 1.000 67.06111 ? 353 GLU   A OE2 1 
ATOM   2155 N  N   . ILE   A 1 354 ? -41.02358 -3.82060  -30.26680 1.000 47.71037 ? 354 ILE   A N   1 
ATOM   2156 C  CA  . ILE   A 1 354 ? -39.88420 -3.40992  -29.46538 1.000 37.47315 ? 354 ILE   A CA  1 
ATOM   2157 C  C   . ILE   A 1 354 ? -38.69786 -4.32772  -29.74138 1.000 44.07679 ? 354 ILE   A C   1 
ATOM   2158 O  O   . ILE   A 1 354 ? -38.84200 -5.55260  -29.85652 1.000 44.72319 ? 354 ILE   A O   1 
ATOM   2159 C  CB  . ILE   A 1 354 ? -40.28787 -3.41749  -27.98415 1.000 44.57155 ? 354 ILE   A CB  1 
ATOM   2160 C  CG1 . ILE   A 1 354 ? -41.50693 -2.50765  -27.79471 1.000 39.75373 ? 354 ILE   A CG1 1 
ATOM   2161 C  CG2 . ILE   A 1 354 ? -39.12663 -3.00957  -27.08917 1.000 40.71868 ? 354 ILE   A CG2 1 
ATOM   2162 C  CD1 . ILE   A 1 354 ? -42.31565 -2.83645  -26.57983 1.000 44.37328 ? 354 ILE   A CD1 1 
ATOM   2163 N  N   . SER   A 1 355 ? -37.51103 -3.72784  -29.88183 1.000 39.22487 ? 355 SER   A N   1 
ATOM   2164 C  CA  . SER   A 1 355 ? -36.30174 -4.48492  -30.17561 1.000 38.21964 ? 355 SER   A CA  1 
ATOM   2165 C  C   . SER   A 1 355 ? -35.90264 -5.30048  -28.94915 1.000 37.25390 ? 355 SER   A C   1 
ATOM   2166 O  O   . SER   A 1 355 ? -36.35800 -5.01913  -27.84120 1.000 37.59858 ? 355 SER   A O   1 
ATOM   2167 C  CB  . SER   A 1 355 ? -35.18751 -3.52672  -30.59257 1.000 34.93856 ? 355 SER   A CB  1 
ATOM   2168 O  OG  . SER   A 1 355 ? -35.68541 -2.52447  -31.46377 1.000 34.17227 ? 355 SER   A OG  1 
ATOM   2169 N  N   . PRO   A 1 356 ? -35.06874 -6.33059  -29.10916 1.000 42.25983 ? 356 PRO   A N   1 
ATOM   2170 C  CA  . PRO   A 1 356 ? -34.67416 -7.09991  -27.92211 1.000 40.61238 ? 356 PRO   A CA  1 
ATOM   2171 C  C   . PRO   A 1 356 ? -34.04591 -6.17485  -26.89203 1.000 40.17871 ? 356 PRO   A C   1 
ATOM   2172 O  O   . PRO   A 1 356 ? -33.21391 -5.33298  -27.22735 1.000 35.30419 ? 356 PRO   A O   1 
ATOM   2173 C  CB  . PRO   A 1 356 ? -33.67164 -8.12693  -28.47228 1.000 40.33877 ? 356 PRO   A CB  1 
ATOM   2174 C  CG  . PRO   A 1 356 ? -33.14248 -7.51493  -29.71934 1.000 45.93671 ? 356 PRO   A CG  1 
ATOM   2175 C  CD  . PRO   A 1 356 ? -34.33683 -6.80220  -30.30663 1.000 43.81053 ? 356 PRO   A CD  1 
ATOM   2176 N  N   . MET   A 1 357 ? -34.51850 -6.28880  -25.64947 1.000 38.25556 ? 357 MET   A N   1 
ATOM   2177 C  CA  . MET   A 1 357 ? -33.98746 -5.62639  -24.44855 1.000 35.47735 ? 357 MET   A CA  1 
ATOM   2178 C  C   . MET   A 1 357 ? -34.40669 -4.16923  -24.33649 1.000 32.49940 ? 357 MET   A C   1 
ATOM   2179 O  O   . MET   A 1 357 ? -33.91129 -3.46210  -23.44722 1.000 33.50494 ? 357 MET   A O   1 
ATOM   2180 C  CB  . MET   A 1 357 ? -32.45645 -5.72854  -24.38437 1.000 34.51367 ? 357 MET   A CB  1 
ATOM   2181 C  CG  . MET   A 1 357 ? -31.97025 -7.17562  -24.42206 1.000 32.39472 ? 357 MET   A CG  1 
ATOM   2182 S  SD  . MET   A 1 357 ? -30.25669 -7.40704  -24.93158 1.000 48.02862 ? 357 MET   A SD  1 
ATOM   2183 C  CE  . MET   A 1 357 ? -30.26896 -6.64773  -26.56018 1.000 31.68612 ? 357 MET   A CE  1 
ATOM   2184 N  N   . CYS   A 1 358 ? -35.30515 -3.68854  -25.18562 1.000 28.83817 ? 358 CYS   A N   1 
ATOM   2185 C  CA  . CYS   A 1 358 ? -35.75511 -2.31110  -25.09135 1.000 29.24952 ? 358 CYS   A CA  1 
ATOM   2186 C  C   . CYS   A 1 358 ? -37.12425 -2.19381  -24.44156 1.000 34.06613 ? 358 CYS   A C   1 
ATOM   2187 O  O   . CYS   A 1 358 ? -37.64370 -1.07903  -24.30748 1.000 30.27422 ? 358 CYS   A O   1 
ATOM   2188 C  CB  . CYS   A 1 358 ? -35.75209 -1.66456  -26.48246 1.000 32.84910 ? 358 CYS   A CB  1 
ATOM   2189 S  SG  . CYS   A 1 358 ? -34.07922 -1.62878  -27.23170 1.000 27.89194 ? 358 CYS   A SG  1 
ATOM   2190 N  N   . ASP   A 1 359 ? -37.70077 -3.31216  -24.00319 1.000 35.16479 ? 359 ASP   A N   1 
ATOM   2191 C  CA  . ASP   A 1 359 ? -39.00855 -3.32937  -23.34787 1.000 39.90453 ? 359 ASP   A CA  1 
ATOM   2192 C  C   . ASP   A 1 359 ? -38.79345 -3.29079  -21.83852 1.000 39.19723 ? 359 ASP   A C   1 
ATOM   2193 O  O   . ASP   A 1 359 ? -38.47107 -4.31035  -21.22440 1.000 40.59683 ? 359 ASP   A O   1 
ATOM   2194 C  CB  . ASP   A 1 359 ? -39.78761 -4.57022  -23.76079 1.000 40.49347 ? 359 ASP   A CB  1 
ATOM   2195 C  CG  . ASP   A 1 359 ? -41.24131 -4.51333  -23.34664 1.000 48.68041 ? 359 ASP   A CG  1 
ATOM   2196 O  OD1 . ASP   A 1 359 ? -41.63062 -3.60132  -22.57468 1.000 38.06616 ? 359 ASP   A OD1 1 
ATOM   2197 O  OD2 . ASP   A 1 359 ? -41.99257 -5.39875  -23.81029 1.000 51.77526 ? 359 ASP   A OD2 1 
ATOM   2198 N  N   . LYS   A 1 360 ? -38.99149 -2.11311  -21.23857 1.000 36.38776 ? 360 LYS   A N   1 
ATOM   2199 C  CA  . LYS   A 1 360 ? -38.83172 -1.98599  -19.79186 1.000 35.60152 ? 360 LYS   A CA  1 
ATOM   2200 C  C   . LYS   A 1 360 ? -39.85980 -2.82218  -19.02517 1.000 47.20785 ? 360 LYS   A C   1 
ATOM   2201 O  O   . LYS   A 1 360 ? -39.58644 -3.24434  -17.89689 1.000 46.72232 ? 360 LYS   A O   1 
ATOM   2202 C  CB  . LYS   A 1 360 ? -38.91865 -0.51618  -19.38115 1.000 33.37166 ? 360 LYS   A CB  1 
ATOM   2203 C  CG  . LYS   A 1 360 ? -40.24086 0.14487   -19.72656 1.000 38.54461 ? 360 LYS   A CG  1 
ATOM   2204 C  CD  . LYS   A 1 360 ? -40.24364 1.63261   -19.41155 1.000 36.45583 ? 360 LYS   A CD  1 
ATOM   2205 C  CE  . LYS   A 1 360 ? -41.52232 2.27836   -19.91404 1.000 32.70264 ? 360 LYS   A CE  1 
ATOM   2206 N  NZ  . LYS   A 1 360 ? -41.46528 3.74953   -19.79588 1.000 33.81677 ? 360 LYS   A NZ  1 
ATOM   2207 N  N   . HIS   A 1 361 ? -41.03285 -3.08653  -19.61510 1.000 47.24730 ? 361 HIS   A N   1 
ATOM   2208 C  CA  . HIS   A 1 361 ? -42.03647 -3.94278  -18.98495 1.000 46.38040 ? 361 HIS   A CA  1 
ATOM   2209 C  C   . HIS   A 1 361 ? -41.73880 -5.42658  -19.14887 1.000 50.96214 ? 361 HIS   A C   1 
ATOM   2210 O  O   . HIS   A 1 361 ? -42.50240 -6.25740  -18.64321 1.000 55.08103 ? 361 HIS   A O   1 
ATOM   2211 C  CB  . HIS   A 1 361 ? -43.43217 -3.64558  -19.54918 1.000 41.08933 ? 361 HIS   A CB  1 
ATOM   2212 C  CG  . HIS   A 1 361 ? -43.82698 -2.20742  -19.44619 1.000 40.13181 ? 361 HIS   A CG  1 
ATOM   2213 N  ND1 . HIS   A 1 361 ? -43.74413 -1.49618  -18.26863 1.000 38.45488 ? 361 HIS   A ND1 1 
ATOM   2214 C  CD2 . HIS   A 1 361 ? -44.29431 -1.34195  -20.37640 1.000 38.35413 ? 361 HIS   A CD2 1 
ATOM   2215 C  CE1 . HIS   A 1 361 ? -44.14566 -0.25504  -18.47755 1.000 32.72136 ? 361 HIS   A CE1 1 
ATOM   2216 N  NE2 . HIS   A 1 361 ? -44.48646 -0.13594  -19.74764 1.000 36.98175 ? 361 HIS   A NE2 1 
ATOM   2217 N  N   . ASN   A 1 362 ? -40.65833 -5.78024  -19.83792 1.000 47.18728 ? 362 ASN   A N   1 
ATOM   2218 C  CA  . ASN   A 1 362 ? -40.33539 -7.17891  -20.07913 1.000 48.16556 ? 362 ASN   A CA  1 
ATOM   2219 C  C   . ASN   A 1 362 ? -38.84121 -7.32621  -20.34212 1.000 52.42752 ? 362 ASN   A C   1 
ATOM   2220 O  O   . ASN   A 1 362 ? -38.42538 -8.11171  -21.20119 1.000 55.71838 ? 362 ASN   A O   1 
ATOM   2221 C  CB  . ASN   A 1 362 ? -41.15341 -7.71737  -21.25608 1.000 50.43657 ? 362 ASN   A CB  1 
ATOM   2222 C  CG  . ASN   A 1 362 ? -41.24957 -9.23432  -21.26522 1.000 60.39234 ? 362 ASN   A CG  1 
ATOM   2223 O  OD1 . ASN   A 1 362 ? -40.33289 -9.93835  -20.83163 1.000 63.22826 ? 362 ASN   A OD1 1 
ATOM   2224 N  ND2 . ASN   A 1 362 ? -42.36864 -9.74671  -21.76675 1.000 65.94142 ? 362 ASN   A ND2 1 
ATOM   2225 N  N   . ALA   A 1 363 ? -38.02647 -6.56760  -19.61928 1.000 46.34246 ? 363 ALA   A N   1 
ATOM   2226 C  CA  . ALA   A 1 363 ? -36.58075 -6.66344  -19.74348 1.000 45.72237 ? 363 ALA   A CA  1 
ATOM   2227 C  C   . ALA   A 1 363 ? -36.01375 -7.57782  -18.66882 1.000 37.67421 ? 363 ALA   A C   1 
ATOM   2228 O  O   . ALA   A 1 363 ? -36.58276 -7.74010  -17.58745 1.000 47.12303 ? 363 ALA   A O   1 
ATOM   2229 C  CB  . ALA   A 1 363 ? -35.92575 -5.28662  -19.64437 1.000 43.22807 ? 363 ALA   A CB  1 
ATOM   2230 N  N   . SER   A 1 364 ? -34.87356 -8.18104  -18.98433 1.000 35.73982 ? 364 SER   A N   1 
ATOM   2231 C  CA  . SER   A 1 364 ? -34.12967 -9.01318  -18.04465 1.000 31.20126 ? 364 SER   A CA  1 
ATOM   2232 C  C   . SER   A 1 364 ? -32.67796 -8.52141  -18.02112 1.000 29.70951 ? 364 SER   A C   1 
ATOM   2233 O  O   . SER   A 1 364 ? -31.83452 -9.04898  -18.75236 1.000 25.58034 ? 364 SER   A O   1 
ATOM   2234 C  CB  . SER   A 1 364 ? -34.22895 -10.46379 -18.44819 1.000 33.93198 ? 364 SER   A CB  1 
ATOM   2235 O  OG  . SER   A 1 364 ? -33.22879 -11.20263 -17.78867 1.000 42.08721 ? 364 SER   A OG  1 
ATOM   2236 N  N   . VAL   A 1 365 ? -32.38683 -7.53016  -17.16641 1.000 24.31570 ? 365 VAL   A N   1 
ATOM   2237 C  CA  . VAL   A 1 365 ? -31.10097 -6.82182  -17.23928 1.000 26.99442 ? 365 VAL   A CA  1 
ATOM   2238 C  C   . VAL   A 1 365 ? -29.93471 -7.77045  -16.97502 1.000 23.63995 ? 365 VAL   A C   1 
ATOM   2239 O  O   . VAL   A 1 365 ? -28.95252 -7.80062  -17.73112 1.000 20.40802 ? 365 VAL   A O   1 
ATOM   2240 C  CB  . VAL   A 1 365 ? -31.07222 -5.63345  -16.25872 1.000 21.86778 ? 365 VAL   A CB  1 
ATOM   2241 C  CG1 . VAL   A 1 365 ? -29.66319 -5.02914  -16.20156 1.000 23.06235 ? 365 VAL   A CG1 1 
ATOM   2242 C  CG2 . VAL   A 1 365 ? -32.10795 -4.58117  -16.65092 1.000 27.48643 ? 365 VAL   A CG2 1 
ATOM   2243 N  N   . GLU   A 1 366 ? -30.01808 -8.54302  -15.88476 1.000 19.76147 ? 366 GLU   A N   1 
ATOM   2244 C  CA  . GLU   A 1 366 ? -28.90637 -9.39993  -15.48733 1.000 21.06391 ? 366 GLU   A CA  1 
ATOM   2245 C  C   . GLU   A 1 366 ? -28.66489 -10.51535 -16.49914 1.000 22.23810 ? 366 GLU   A C   1 
ATOM   2246 O  O   . GLU   A 1 366 ? -27.51340 -10.80731 -16.83663 1.000 21.91913 ? 366 GLU   A O   1 
ATOM   2247 C  CB  . GLU   A 1 366 ? -29.15359 -9.99859  -14.09968 1.000 25.15472 ? 366 GLU   A CB  1 
ATOM   2248 C  CG  . GLU   A 1 366 ? -29.33550 -8.98964  -12.98370 1.000 21.55943 ? 366 GLU   A CG  1 
ATOM   2249 C  CD  . GLU   A 1 366 ? -30.69155 -8.31015  -13.01662 1.000 25.72897 ? 366 GLU   A CD  1 
ATOM   2250 O  OE1 . GLU   A 1 366 ? -30.80425 -7.19999  -12.46170 1.000 25.08246 ? 366 GLU   A OE1 1 
ATOM   2251 O  OE2 . GLU   A 1 366 ? -31.63686 -8.86745  -13.61376 1.000 23.07638 ? 366 GLU   A OE2 1 
ATOM   2252 N  N   . LYS   A 1 367 ? -29.72467 -11.17730 -16.97195 1.000 22.51281 ? 367 LYS   A N   1 
ATOM   2253 C  CA  . LYS   A 1 367 ? -29.50770 -12.26477 -17.92370 1.000 25.13423 ? 367 LYS   A CA  1 
ATOM   2254 C  C   . LYS   A 1 367 ? -28.96132 -11.73612 -19.24478 1.000 20.66703 ? 367 LYS   A C   1 
ATOM   2255 O  O   . LYS   A 1 367 ? -28.17563 -12.42076 -19.91340 1.000 17.16518 ? 367 LYS   A O   1 
ATOM   2256 C  CB  . LYS   A 1 367 ? -30.80447 -13.05133 -18.15711 1.000 27.13805 ? 367 LYS   A CB  1 
ATOM   2257 C  CG  . LYS   A 1 367 ? -30.58461 -14.50121 -18.61651 1.000 34.51851 ? 367 LYS   A CG  1 
ATOM   2258 C  CD  . LYS   A 1 367 ? -31.85097 -15.15050 -19.20253 1.000 29.36698 ? 367 LYS   A CD  1 
ATOM   2259 C  CE  . LYS   A 1 367 ? -33.04998 -14.94665 -18.29816 1.000 34.98852 ? 367 LYS   A CE  1 
ATOM   2260 N  NZ  . LYS   A 1 367 ? -34.25602 -15.65490 -18.82761 1.000 31.05548 ? 367 LYS   A NZ  1 
ATOM   2261 N  N   . SER   A 1 368 ? -29.36721 -10.52381 -19.62781 1.000 19.58130 ? 368 SER   A N   1 
ATOM   2262 C  CA  . SER   A 1 368 ? -28.86519 -9.91307  -20.85451 1.000 23.67389 ? 368 SER   A CA  1 
ATOM   2263 C  C   . SER   A 1 368 ? -27.38588 -9.57517  -20.74320 1.000 20.46744 ? 368 SER   A C   1 
ATOM   2264 O  O   . SER   A 1 368 ? -26.64038 -9.72088  -21.71923 1.000 18.56668 ? 368 SER   A O   1 
ATOM   2265 C  CB  . SER   A 1 368 ? -29.66727 -8.65694  -21.17964 1.000 24.39095 ? 368 SER   A CB  1 
ATOM   2266 O  OG  . SER   A 1 368 ? -30.97286 -9.00241  -21.57354 1.000 26.10057 ? 368 SER   A OG  1 
ATOM   2267 N  N   . GLN   A 1 369 ? -26.93990 -9.10290  -19.57169 1.000 18.25886 ? 369 GLN   A N   1 
ATOM   2268 C  CA  . GLN   A 1 369 ? -25.51161 -8.84819  -19.41154 1.000 17.01439 ? 369 GLN   A CA  1 
ATOM   2269 C  C   . GLN   A 1 369 ? -24.71861 -10.14893 -19.49127 1.000 18.33729 ? 369 GLN   A C   1 
ATOM   2270 O  O   . GLN   A 1 369 ? -23.66222 -10.19802 -20.13770 1.000 16.87037 ? 369 GLN   A O   1 
ATOM   2271 C  CB  . GLN   A 1 369 ? -25.22984 -8.11079  -18.09795 1.000 17.43134 ? 369 GLN   A CB  1 
ATOM   2272 C  CG  . GLN   A 1 369 ? -25.53582 -6.61065  -18.12557 1.000 15.05126 ? 369 GLN   A CG  1 
ATOM   2273 C  CD  . GLN   A 1 369 ? -24.84576 -5.89316  -19.28833 1.000 17.15578 ? 369 GLN   A CD  1 
ATOM   2274 O  OE1 . GLN   A 1 369 ? -23.62733 -5.96439  -19.43878 1.000 15.78071 ? 369 GLN   A OE1 1 
ATOM   2275 N  NE2 . GLN   A 1 369 ? -25.63553 -5.22401  -20.13339 1.000 13.36758 ? 369 GLN   A NE2 1 
ATOM   2276 N  N   . VAL   A 1 370 ? -25.22898 -11.22606 -18.88008 1.000 16.62941 ? 370 VAL   A N   1 
ATOM   2277 C  CA  . VAL   A 1 370 ? -24.52797 -12.51055 -18.95384 1.000 17.54106 ? 370 VAL   A CA  1 
ATOM   2278 C  C   . VAL   A 1 370 ? -24.42047 -12.98649 -20.40710 1.000 16.40654 ? 370 VAL   A C   1 
ATOM   2279 O  O   . VAL   A 1 370 ? -23.37276 -13.48415 -20.83542 1.000 18.28604 ? 370 VAL   A O   1 
ATOM   2280 C  CB  . VAL   A 1 370 ? -25.21852 -13.56102 -18.06064 1.000 18.23098 ? 370 VAL   A CB  1 
ATOM   2281 C  CG1 . VAL   A 1 370 ? -24.55277 -14.90977 -18.23994 1.000 18.02973 ? 370 VAL   A CG1 1 
ATOM   2282 C  CG2 . VAL   A 1 370 ? -25.18162 -13.14356 -16.58718 1.000 17.11141 ? 370 VAL   A CG2 1 
ATOM   2283 N  N   . GLY   A 1 371 ? -25.48898 -12.83577 -21.19026 1.000 16.15014 ? 371 GLY   A N   1 
ATOM   2284 C  CA  . GLY   A 1 371 ? -25.42141 -13.24889 -22.58901 1.000 17.72025 ? 371 GLY   A CA  1 
ATOM   2285 C  C   . GLY   A 1 371 ? -24.53303 -12.34478 -23.42784 1.000 19.07716 ? 371 GLY   A C   1 
ATOM   2286 O  O   . GLY   A 1 371 ? -23.83722 -12.80667 -24.33948 1.000 20.66578 ? 371 GLY   A O   1 
ATOM   2287 N  N   . PHE   A 1 372 ? -24.55153 -11.04635 -23.12953 1.000 14.09238 ? 372 PHE   A N   1 
ATOM   2288 C  CA  . PHE   A 1 372 ? -23.64950 -10.08600 -23.76331 1.000 21.47558 ? 372 PHE   A CA  1 
ATOM   2289 C  C   . PHE   A 1 372 ? -22.19018 -10.48676 -23.56196 1.000 15.15200 ? 372 PHE   A C   1 
ATOM   2290 O  O   . PHE   A 1 372 ? -21.40815 -10.53403 -24.51571 1.000 16.45241 ? 372 PHE   A O   1 
ATOM   2291 C  CB  . PHE   A 1 372 ? -23.93080 -8.69331  -23.18757 1.000 14.61661 ? 372 PHE   A CB  1 
ATOM   2292 C  CG  . PHE   A 1 372 ? -23.09808 -7.58070  -23.78464 1.000 18.41091 ? 372 PHE   A CG  1 
ATOM   2293 C  CD1 . PHE   A 1 372 ? -22.93949 -7.46091  -25.15882 1.000 18.67615 ? 372 PHE   A CD1 1 
ATOM   2294 C  CD2 . PHE   A 1 372 ? -22.52099 -6.61812  -22.96095 1.000 17.23456 ? 372 PHE   A CD2 1 
ATOM   2295 C  CE1 . PHE   A 1 372 ? -22.17339 -6.42120  -25.70784 1.000 17.96204 ? 372 PHE   A CE1 1 
ATOM   2296 C  CE2 . PHE   A 1 372 ? -21.77125 -5.56927  -23.49921 1.000 16.57229 ? 372 PHE   A CE2 1 
ATOM   2297 C  CZ  . PHE   A 1 372 ? -21.59870 -5.47134  -24.87914 1.000 15.73444 ? 372 PHE   A CZ  1 
ATOM   2298 N  N   . ILE   A 1 373 ? -21.81096 -10.80922 -22.32460 1.000 17.89731 ? 373 ILE   A N   1 
ATOM   2299 C  CA  . ILE   A 1 373 ? -20.44390 -11.25282 -22.06154 1.000 15.28240 ? 373 ILE   A CA  1 
ATOM   2300 C  C   . ILE   A 1 373 ? -20.16287 -12.58418 -22.75489 1.000 17.46947 ? 373 ILE   A C   1 
ATOM   2301 O  O   . ILE   A 1 373 ? -19.10918 -12.76306 -23.38258 1.000 17.58897 ? 373 ILE   A O   1 
ATOM   2302 C  CB  . ILE   A 1 373 ? -20.19930 -11.35039 -20.54289 1.000 12.17217 ? 373 ILE   A CB  1 
ATOM   2303 C  CG1 . ILE   A 1 373 ? -20.24619 -9.96289  -19.89478 1.000 14.66096 ? 373 ILE   A CG1 1 
ATOM   2304 C  CG2 . ILE   A 1 373 ? -18.86694 -12.02634 -20.25251 1.000 16.03254 ? 373 ILE   A CG2 1 
ATOM   2305 C  CD1 . ILE   A 1 373 ? -20.17921 -10.02362 -18.38784 1.000 15.17771 ? 373 ILE   A CD1 1 
ATOM   2306 N  N   . ASP   A 1 374 ? -21.09614 -13.53586 -22.64640 1.000 17.50097 ? 374 ASP   A N   1 
ATOM   2307 C  CA  . ASP   A 1 374 ? -20.85043 -14.90480 -23.11083 1.000 18.35099 ? 374 ASP   A CA  1 
ATOM   2308 C  C   . ASP   A 1 374 ? -20.70010 -14.98148 -24.63223 1.000 18.29364 ? 374 ASP   A C   1 
ATOM   2309 O  O   . ASP   A 1 374 ? -19.84180 -15.71897 -25.13026 1.000 19.98342 ? 374 ASP   A O   1 
ATOM   2310 C  CB  . ASP   A 1 374 ? -21.97946 -15.83958 -22.64753 1.000 16.00891 ? 374 ASP   A CB  1 
ATOM   2311 C  CG  . ASP   A 1 374 ? -21.89009 -16.20593 -21.16062 1.000 16.75264 ? 374 ASP   A CG  1 
ATOM   2312 O  OD1 . ASP   A 1 374 ? -20.89487 -15.86906 -20.48898 1.000 17.01050 ? 374 ASP   A OD1 1 
ATOM   2313 O  OD2 . ASP   A 1 374 ? -22.81395 -16.88446 -20.66775 1.000 21.23351 ? 374 ASP   A OD2 1 
ATOM   2314 N  N   . TYR   A 1 375 ? -21.52091 -14.23816 -25.38642 1.000 15.41670 ? 375 TYR   A N   1 
ATOM   2315 C  CA  . TYR   A 1 375 ? -21.54273 -14.33922 -26.84248 1.000 16.21759 ? 375 TYR   A CA  1 
ATOM   2316 C  C   . TYR   A 1 375 ? -20.81435 -13.20915 -27.57037 1.000 20.74142 ? 375 TYR   A C   1 
ATOM   2317 O  O   . TYR   A 1 375 ? -20.65311 -13.29636 -28.79259 1.000 17.78832 ? 375 TYR   A O   1 
ATOM   2318 C  CB  . TYR   A 1 375 ? -22.98688 -14.39290 -27.35546 1.000 21.27257 ? 375 TYR   A CB  1 
ATOM   2319 C  CG  . TYR   A 1 375 ? -23.70441 -15.67356 -26.98643 1.000 22.61727 ? 375 TYR   A CG  1 
ATOM   2320 C  CD1 . TYR   A 1 375 ? -23.41302 -16.86482 -27.64099 1.000 27.41504 ? 375 TYR   A CD1 1 
ATOM   2321 C  CD2 . TYR   A 1 375 ? -24.66653 -15.69483 -25.97900 1.000 27.19820 ? 375 TYR   A CD2 1 
ATOM   2322 C  CE1 . TYR   A 1 375 ? -24.05909 -18.05504 -27.30523 1.000 32.83376 ? 375 TYR   A CE1 1 
ATOM   2323 C  CE2 . TYR   A 1 375 ? -25.32061 -16.87865 -25.63072 1.000 32.59619 ? 375 TYR   A CE2 1 
ATOM   2324 C  CZ  . TYR   A 1 375 ? -25.01077 -18.05631 -26.29869 1.000 32.51795 ? 375 TYR   A CZ  1 
ATOM   2325 O  OH  . TYR   A 1 375 ? -25.65405 -19.23468 -25.97009 1.000 39.04867 ? 375 TYR   A OH  1 
ATOM   2326 N  N   . ILE   A 1 376 ? -20.38302 -12.15451 -26.87595 1.000 16.74023 ? 376 ILE   A N   1 
ATOM   2327 C  CA  . ILE   A 1 376 ? -19.75207 -11.02065 -27.54933 1.000 16.33802 ? 376 ILE   A CA  1 
ATOM   2328 C  C   . ILE   A 1 376 ? -18.47362 -10.60741 -26.84357 1.000 17.09100 ? 376 ILE   A C   1 
ATOM   2329 O  O   . ILE   A 1 376 ? -17.38385 -10.66099 -27.42832 1.000 15.47925 ? 376 ILE   A O   1 
ATOM   2330 C  CB  . ILE   A 1 376 ? -20.68886 -9.79507  -27.64107 1.000 16.66124 ? 376 ILE   A CB  1 
ATOM   2331 C  CG1 . ILE   A 1 376 ? -21.96285 -10.10713 -28.44203 1.000 20.57405 ? 376 ILE   A CG1 1 
ATOM   2332 C  CG2 . ILE   A 1 376 ? -19.92798 -8.59311  -28.22072 1.000 12.53551 ? 376 ILE   A CG2 1 
ATOM   2333 C  CD1 . ILE   A 1 376 ? -21.70634 -10.44164 -29.88611 1.000 27.94325 ? 376 ILE   A CD1 1 
ATOM   2334 N  N   . VAL   A 1 377 ? -18.60199 -10.16895 -25.58638 1.000 15.19735 ? 377 VAL   A N   1 
ATOM   2335 C  CA  . VAL   A 1 377 ? -17.50125 -9.45535  -24.93720 1.000 13.58954 ? 377 VAL   A CA  1 
ATOM   2336 C  C   . VAL   A 1 377 ? -16.37965 -10.41335 -24.56065 1.000 15.69950 ? 377 VAL   A C   1 
ATOM   2337 O  O   . VAL   A 1 377 ? -15.19979 -10.12919 -24.79746 1.000 12.99039 ? 377 VAL   A O   1 
ATOM   2338 C  CB  . VAL   A 1 377 ? -18.00605 -8.66865  -23.71441 1.000 13.70536 ? 377 VAL   A CB  1 
ATOM   2339 C  CG1 . VAL   A 1 377 ? -16.83026 -7.95689  -23.00924 1.000 8.64356  ? 377 VAL   A CG1 1 
ATOM   2340 C  CG2 . VAL   A 1 377 ? -19.05429 -7.66288  -24.15321 1.000 12.26093 ? 377 VAL   A CG2 1 
ATOM   2341 N  N   . HIS   A 1 378 ? -16.72385 -11.56607 -23.97185 1.000 17.51259 ? 378 HIS   A N   1 
ATOM   2342 C  CA  . HIS   A 1 378 ? -15.66493 -12.49910 -23.59199 1.000 16.18922 ? 378 HIS   A CA  1 
ATOM   2343 C  C   . HIS   A 1 378 ? -14.99111 -13.14836 -24.80768 1.000 15.79747 ? 378 HIS   A C   1 
ATOM   2344 O  O   . HIS   A 1 378 ? -13.75633 -13.24103 -24.82457 1.000 16.84941 ? 378 HIS   A O   1 
ATOM   2345 C  CB  . HIS   A 1 378 ? -16.17936 -13.57007 -22.62072 1.000 16.09003 ? 378 HIS   A CB  1 
ATOM   2346 C  CG  . HIS   A 1 378 ? -15.08503 -14.38744 -22.00565 1.000 16.75366 ? 378 HIS   A CG  1 
ATOM   2347 N  ND1 . HIS   A 1 378 ? -14.49094 -15.44848 -22.65796 1.000 21.98227 ? 378 HIS   A ND1 1 
ATOM   2348 C  CD2 . HIS   A 1 378 ? -14.45869 -14.28366 -20.80938 1.000 17.04542 ? 378 HIS   A CD2 1 
ATOM   2349 C  CE1 . HIS   A 1 378 ? -13.55026 -15.96714 -21.88576 1.000 19.12507 ? 378 HIS   A CE1 1 
ATOM   2350 N  NE2 . HIS   A 1 378 ? -13.51512 -15.28210 -20.75514 1.000 19.66717 ? 378 HIS   A NE2 1 
ATOM   2351 N  N   . PRO   A 1 379 ? -15.72041 -13.61132 -25.83631 1.000 17.18706 ? 379 PRO   A N   1 
ATOM   2352 C  CA  . PRO   A 1 379 ? -15.00721 -14.11127 -27.03220 1.000 17.13398 ? 379 PRO   A CA  1 
ATOM   2353 C  C   . PRO   A 1 379 ? -14.04084 -13.09224 -27.62046 1.000 19.49992 ? 379 PRO   A C   1 
ATOM   2354 O  O   . PRO   A 1 379 ? -12.93790 -13.46655 -28.03690 1.000 17.76024 ? 379 PRO   A O   1 
ATOM   2355 C  CB  . PRO   A 1 379 ? -16.13849 -14.44911 -28.01065 1.000 17.37450 ? 379 PRO   A CB  1 
ATOM   2356 C  CG  . PRO   A 1 379 ? -17.32661 -14.73176 -27.13571 1.000 19.50919 ? 379 PRO   A CG  1 
ATOM   2357 C  CD  . PRO   A 1 379 ? -17.18202 -13.78453 -25.96405 1.000 16.55840 ? 379 PRO   A CD  1 
ATOM   2358 N  N   . LEU   A 1 380 ? -14.41570 -11.80935 -27.64052 1.000 14.44269 ? 380 LEU   A N   1 
ATOM   2359 C  CA  . LEU   A 1 380 ? -13.50815 -10.76543 -28.10831 1.000 13.02204 ? 380 LEU   A CA  1 
ATOM   2360 C  C   . LEU   A 1 380 ? -12.31586 -10.59830 -27.17105 1.000 15.35814 ? 380 LEU   A C   1 
ATOM   2361 O  O   . LEU   A 1 380 ? -11.16033 -10.62427 -27.61152 1.000 15.43079 ? 380 LEU   A O   1 
ATOM   2362 C  CB  . LEU   A 1 380 ? -14.26529 -9.44602  -28.24164 1.000 17.64680 ? 380 LEU   A CB  1 
ATOM   2363 C  CG  . LEU   A 1 380 ? -13.47303 -8.17537  -28.56314 1.000 16.32654 ? 380 LEU   A CG  1 
ATOM   2364 C  CD1 . LEU   A 1 380 ? -12.73657 -8.31781  -29.89945 1.000 17.01339 ? 380 LEU   A CD1 1 
ATOM   2365 C  CD2 . LEU   A 1 380 ? -14.43498 -6.96056  -28.58845 1.000 10.32775 ? 380 LEU   A CD2 1 
ATOM   2366 N  N   . TRP   A 1 381 ? -12.57251 -10.40666 -25.87173 1.000 14.03534 ? 381 TRP   A N   1 
ATOM   2367 C  CA  . TRP   A 1 381 ? -11.48107 -10.08828 -24.95864 1.000 13.65106 ? 381 TRP   A CA  1 
ATOM   2368 C  C   . TRP   A 1 381 ? -10.56303 -11.28540 -24.72305 1.000 15.96383 ? 381 TRP   A C   1 
ATOM   2369 O  O   . TRP   A 1 381 ? -9.37049  -11.10661 -24.46102 1.000 14.75214 ? 381 TRP   A O   1 
ATOM   2370 C  CB  . TRP   A 1 381 ? -12.03708 -9.55431  -23.63587 1.000 13.42544 ? 381 TRP   A CB  1 
ATOM   2371 C  CG  . TRP   A 1 381 ? -12.21409 -8.06147  -23.69880 1.000 13.47967 ? 381 TRP   A CG  1 
ATOM   2372 C  CD1 . TRP   A 1 381 ? -13.36534 -7.38794  -23.97115 1.000 10.44896 ? 381 TRP   A CD1 1 
ATOM   2373 C  CD2 . TRP   A 1 381 ? -11.18338 -7.06573  -23.56580 1.000 11.61016 ? 381 TRP   A CD2 1 
ATOM   2374 N  NE1 . TRP   A 1 381 ? -13.12330 -6.02688  -23.99817 1.000 12.82534 ? 381 TRP   A NE1 1 
ATOM   2375 C  CE2 . TRP   A 1 381 ? -11.79448 -5.80489  -23.74666 1.000 12.81905 ? 381 TRP   A CE2 1 
ATOM   2376 C  CE3 . TRP   A 1 381 ? -9.80749  -7.11877  -23.29967 1.000 13.01929 ? 381 TRP   A CE3 1 
ATOM   2377 C  CZ2 . TRP   A 1 381 ? -11.08203 -4.60049  -23.65069 1.000 11.55177 ? 381 TRP   A CZ2 1 
ATOM   2378 C  CZ3 . TRP   A 1 381 ? -9.09717  -5.91982  -23.21191 1.000 16.77271 ? 381 TRP   A CZ3 1 
ATOM   2379 C  CH2 . TRP   A 1 381 ? -9.74185  -4.67738  -23.39362 1.000 13.04160 ? 381 TRP   A CH2 1 
ATOM   2380 N  N   . GLU   A 1 382 ? -11.09647 -12.50231 -24.81080 1.000 15.48470 ? 382 GLU   A N   1 
ATOM   2381 C  CA  . GLU   A 1 382 ? -10.25161 -13.69362 -24.74428 1.000 17.97706 ? 382 GLU   A CA  1 
ATOM   2382 C  C   . GLU   A 1 382 ? -9.30224  -13.76655 -25.94212 1.000 19.55028 ? 382 GLU   A C   1 
ATOM   2383 O  O   . GLU   A 1 382 ? -8.13912  -14.16931 -25.80552 1.000 17.59583 ? 382 GLU   A O   1 
ATOM   2384 C  CB  . GLU   A 1 382 ? -11.14933 -14.92665 -24.67054 1.000 20.69664 ? 382 GLU   A CB  1 
ATOM   2385 C  CG  . GLU   A 1 382 ? -10.45436 -16.26605 -24.67296 1.000 28.30467 ? 382 GLU   A CG  1 
ATOM   2386 C  CD  . GLU   A 1 382 ? -11.46008 -17.39690 -24.49961 1.000 30.86514 ? 382 GLU   A CD  1 
ATOM   2387 O  OE1 . GLU   A 1 382 ? -12.53518 -17.36758 -25.16199 1.000 30.58766 ? 382 GLU   A OE1 1 
ATOM   2388 O  OE2 . GLU   A 1 382 ? -11.18262 -18.29286 -23.68039 1.000 37.30118 ? 382 GLU   A OE2 1 
ATOM   2389 N  N   . THR   A 1 383 ? -9.77527  -13.35962 -27.12010 1.000 14.93680 ? 383 THR   A N   1 
ATOM   2390 C  CA  . THR   A 1 383 ? -8.91933  -13.36187 -28.29750 1.000 16.85844 ? 383 THR   A CA  1 
ATOM   2391 C  C   . THR   A 1 383 ? -7.88823  -12.23821 -28.22123 1.000 18.58269 ? 383 THR   A C   1 
ATOM   2392 O  O   . THR   A 1 383 ? -6.71032  -12.46156 -28.50174 1.000 18.44775 ? 383 THR   A O   1 
ATOM   2393 C  CB  . THR   A 1 383 ? -9.78676  -13.26736 -29.55672 1.000 16.27355 ? 383 THR   A CB  1 
ATOM   2394 O  OG1 . THR   A 1 383 ? -10.72979 -14.34927 -29.55712 1.000 14.24818 ? 383 THR   A OG1 1 
ATOM   2395 C  CG2 . THR   A 1 383 ? -8.95608  -13.35761 -30.80531 1.000 14.93102 ? 383 THR   A CG2 1 
ATOM   2396 N  N   . TRP   A 1 384 ? -8.30183  -11.03302 -27.80318 1.000 16.72164 ? 384 TRP   A N   1 
ATOM   2397 C  CA  . TRP   A 1 384 ? -7.32545  -9.97366  -27.57149 1.000 17.32479 ? 384 TRP   A CA  1 
ATOM   2398 C  C   . TRP   A 1 384 ? -6.29863  -10.38902 -26.52170 1.000 18.93983 ? 384 TRP   A C   1 
ATOM   2399 O  O   . TRP   A 1 384 ? -5.09813  -10.14405 -26.69118 1.000 16.01510 ? 384 TRP   A O   1 
ATOM   2400 C  CB  . TRP   A 1 384 ? -8.01765  -8.66816  -27.15684 1.000 14.11986 ? 384 TRP   A CB  1 
ATOM   2401 C  CG  . TRP   A 1 384 ? -7.04111  -7.54779  -26.96415 1.000 14.48763 ? 384 TRP   A CG  1 
ATOM   2402 C  CD1 . TRP   A 1 384 ? -6.43974  -7.18048  -25.79839 1.000 17.32305 ? 384 TRP   A CD1 1 
ATOM   2403 C  CD2 . TRP   A 1 384 ? -6.52636  -6.66147  -27.97748 1.000 13.75188 ? 384 TRP   A CD2 1 
ATOM   2404 N  NE1 . TRP   A 1 384 ? -5.58793  -6.11411  -26.01857 1.000 13.58789 ? 384 TRP   A NE1 1 
ATOM   2405 C  CE2 . TRP   A 1 384 ? -5.62056  -5.78604  -27.34734 1.000 13.67211 ? 384 TRP   A CE2 1 
ATOM   2406 C  CE3 . TRP   A 1 384 ? -6.75134  -6.52241  -29.34777 1.000 14.05882 ? 384 TRP   A CE3 1 
ATOM   2407 C  CZ2 . TRP   A 1 384 ? -4.94300  -4.77587  -28.04328 1.000 16.75421 ? 384 TRP   A CZ2 1 
ATOM   2408 C  CZ3 . TRP   A 1 384 ? -6.07190  -5.52191  -30.04228 1.000 17.78842 ? 384 TRP   A CZ3 1 
ATOM   2409 C  CH2 . TRP   A 1 384 ? -5.18034  -4.66435  -29.38793 1.000 15.52143 ? 384 TRP   A CH2 1 
ATOM   2410 N  N   . ALA   A 1 385 ? -6.74463  -11.02263 -25.42943 1.000 16.77335 ? 385 ALA   A N   1 
ATOM   2411 C  CA  . ALA   A 1 385 ? -5.79311  -11.46822 -24.41252 1.000 16.93973 ? 385 ALA   A CA  1 
ATOM   2412 C  C   . ALA   A 1 385 ? -4.76211  -12.43475 -25.00602 1.000 21.48369 ? 385 ALA   A C   1 
ATOM   2413 O  O   . ALA   A 1 385 ? -3.56723  -12.34119 -24.69992 1.000 22.09409 ? 385 ALA   A O   1 
ATOM   2414 C  CB  . ALA   A 1 385 ? -6.53351  -12.10914 -23.23129 1.000 15.65878 ? 385 ALA   A CB  1 
ATOM   2415 N  N   . ASP   A 1 386 ? -5.20097  -13.34841 -25.87812 1.000 22.88978 ? 386 ASP   A N   1 
ATOM   2416 C  CA  . ASP   A 1 386 ? -4.26539  -14.24682 -26.56623 1.000 22.51806 ? 386 ASP   A CA  1 
ATOM   2417 C  C   . ASP   A 1 386 ? -3.27264  -13.47482 -27.42666 1.000 23.30390 ? 386 ASP   A C   1 
ATOM   2418 O  O   . ASP   A 1 386 ? -2.08168  -13.80721 -27.46321 1.000 22.09070 ? 386 ASP   A O   1 
ATOM   2419 C  CB  . ASP   A 1 386 ? -5.02472  -15.24924 -27.43927 1.000 26.64635 ? 386 ASP   A CB  1 
ATOM   2420 C  CG  . ASP   A 1 386 ? -5.59247  -16.41646 -26.64589 1.000 34.81881 ? 386 ASP   A CG  1 
ATOM   2421 O  OD1 . ASP   A 1 386 ? -5.30397  -16.51391 -25.42893 1.000 37.51165 ? 386 ASP   A OD1 1 
ATOM   2422 O  OD2 . ASP   A 1 386 ? -6.32383  -17.24012 -27.24363 1.000 36.36154 ? 386 ASP   A OD2 1 
ATOM   2423 N  N   . LEU   A 1 387 ? -3.74354  -12.43318 -28.12022 1.000 23.03963 ? 387 LEU   A N   1 
ATOM   2424 C  CA  . LEU   A 1 387 ? -2.86779  -11.66075 -28.99791 1.000 21.10710 ? 387 LEU   A CA  1 
ATOM   2425 C  C   . LEU   A 1 387 ? -1.71163  -11.02932 -28.22592 1.000 22.09276 ? 387 LEU   A C   1 
ATOM   2426 O  O   . LEU   A 1 387 ? -0.58022  -10.98003 -28.71876 1.000 24.44393 ? 387 LEU   A O   1 
ATOM   2427 C  CB  . LEU   A 1 387 ? -3.68070  -10.58392 -29.72616 1.000 18.57207 ? 387 LEU   A CB  1 
ATOM   2428 C  CG  . LEU   A 1 387 ? -2.92141  -9.77246  -30.77567 1.000 22.26487 ? 387 LEU   A CG  1 
ATOM   2429 C  CD1 . LEU   A 1 387 ? -2.70815  -10.62167 -32.03743 1.000 23.95276 ? 387 LEU   A CD1 1 
ATOM   2430 C  CD2 . LEU   A 1 387 ? -3.64785  -8.47706  -31.09809 1.000 23.97994 ? 387 LEU   A CD2 1 
ATOM   2431 N  N   . VAL   A 1 388 ? -1.97308  -10.54119 -27.01931 1.000 19.95633 ? 388 VAL   A N   1 
ATOM   2432 C  CA  . VAL   A 1 388 ? -0.98933  -9.79349  -26.24143 1.000 19.95700 ? 388 VAL   A CA  1 
ATOM   2433 C  C   . VAL   A 1 388 ? -0.56621  -10.56449 -24.98900 1.000 20.49023 ? 388 VAL   A C   1 
ATOM   2434 O  O   . VAL   A 1 388 ? -0.08407  -9.97090  -24.02348 1.000 18.23328 ? 388 VAL   A O   1 
ATOM   2435 C  CB  . VAL   A 1 388 ? -1.52621  -8.39737  -25.88004 1.000 22.12997 ? 388 VAL   A CB  1 
ATOM   2436 C  CG1 . VAL   A 1 388 ? -1.95968  -7.66607  -27.14064 1.000 21.33034 ? 388 VAL   A CG1 1 
ATOM   2437 C  CG2 . VAL   A 1 388 ? -2.68801  -8.50675  -24.88501 1.000 18.68283 ? 388 VAL   A CG2 1 
ATOM   2438 N  N   . HIS   A 1 389 ? -0.77122  -11.87822 -24.98296 1.000 23.04968 ? 389 HIS   A N   1 
ATOM   2439 C  CA  . HIS   A 1 389 ? -0.55807  -12.69564 -23.79636 1.000 23.69651 ? 389 HIS   A CA  1 
ATOM   2440 C  C   . HIS   A 1 389 ? 0.85810   -12.50227 -23.23782 1.000 28.88858 ? 389 HIS   A C   1 
ATOM   2441 O  O   . HIS   A 1 389 ? 1.83668   -12.54330 -23.99245 1.000 25.82223 ? 389 HIS   A O   1 
ATOM   2442 C  CB  . HIS   A 1 389 ? -0.82647  -14.16544 -24.13156 1.000 29.99860 ? 389 HIS   A CB  1 
ATOM   2443 C  CG  . HIS   A 1 389 ? -1.07637  -15.02608 -22.93140 1.000 35.28613 ? 389 HIS   A CG  1 
ATOM   2444 N  ND1 . HIS   A 1 389 ? -2.32908  -15.20443 -22.38631 1.000 38.15070 ? 389 HIS   A ND1 1 
ATOM   2445 C  CD2 . HIS   A 1 389 ? -0.22848  -15.75011 -22.16561 1.000 34.47500 ? 389 HIS   A CD2 1 
ATOM   2446 C  CE1 . HIS   A 1 389 ? -2.24069  -16.00635 -21.34001 1.000 38.32332 ? 389 HIS   A CE1 1 
ATOM   2447 N  NE2 . HIS   A 1 389 ? -0.97547  -16.34945 -21.18359 1.000 38.93610 ? 389 HIS   A NE2 1 
ATOM   2448 N  N   . PRO   A 1 390 ? 0.96875   -12.27832 -21.91139 1.000 25.15893 ? 390 PRO   A N   1 
ATOM   2449 C  CA  . PRO   A 1 390 ? -0.13234  -12.28434 -20.94369 1.000 25.75813 ? 390 PRO   A CA  1 
ATOM   2450 C  C   . PRO   A 1 390 ? -0.54107  -10.88627 -20.46103 1.000 20.45132 ? 390 PRO   A C   1 
ATOM   2451 O  O   . PRO   A 1 390 ? -1.00125  -10.76793 -19.33054 1.000 21.19291 ? 390 PRO   A O   1 
ATOM   2452 C  CB  . PRO   A 1 390 ? 0.46418   -13.07423 -19.78241 1.000 26.37652 ? 390 PRO   A CB  1 
ATOM   2453 C  CG  . PRO   A 1 390 ? 1.90490   -12.54371 -19.74806 1.000 26.18979 ? 390 PRO   A CG  1 
ATOM   2454 C  CD  . PRO   A 1 390 ? 2.26941   -12.21132 -21.21559 1.000 28.95624 ? 390 PRO   A CD  1 
ATOM   2455 N  N   . ASP   A 1 391 ? -0.35116  -9.86035  -21.29687 1.000 21.99718 ? 391 ASP   A N   1 
ATOM   2456 C  CA  . ASP   A 1 391 ? -0.54398  -8.47473  -20.85555 1.000 23.23197 ? 391 ASP   A CA  1 
ATOM   2457 C  C   . ASP   A 1 391 ? -1.93520  -8.22684  -20.27555 1.000 20.39626 ? 391 ASP   A C   1 
ATOM   2458 O  O   . ASP   A 1 391 ? -2.07590  -7.46743  -19.31336 1.000 21.18791 ? 391 ASP   A O   1 
ATOM   2459 C  CB  . ASP   A 1 391 ? -0.31253  -7.51462  -22.02418 1.000 20.17838 ? 391 ASP   A CB  1 
ATOM   2460 C  CG  . ASP   A 1 391 ? 1.11333   -7.56584  -22.57274 1.000 24.95730 ? 391 ASP   A CG  1 
ATOM   2461 O  OD1 . ASP   A 1 391 ? 1.99242   -8.20449  -21.95579 1.000 25.60259 ? 391 ASP   A OD1 1 
ATOM   2462 O  OD2 . ASP   A 1 391 ? 1.34513   -6.95470  -23.63203 1.000 26.18415 ? 391 ASP   A OD2 1 
ATOM   2463 N  N   . ALA   A 1 392 ? -2.97057  -8.85225  -20.83581 1.000 17.78480 ? 392 ALA   A N   1 
ATOM   2464 C  CA  . ALA   A 1 392 ? -4.35253  -8.53743  -20.48762 1.000 17.63835 ? 392 ALA   A CA  1 
ATOM   2465 C  C   . ALA   A 1 392 ? -4.97601  -9.51601  -19.48492 1.000 19.34477 ? 392 ALA   A C   1 
ATOM   2466 O  O   . ALA   A 1 392 ? -6.20592  -9.57446  -19.37938 1.000 17.03873 ? 392 ALA   A O   1 
ATOM   2467 C  CB  . ALA   A 1 392 ? -5.20507  -8.48298  -21.75896 1.000 15.82372 ? 392 ALA   A CB  1 
ATOM   2468 N  N   . GLN   A 1 393 ? -4.16873  -10.26723 -18.72718 1.000 18.20062 ? 393 GLN   A N   1 
ATOM   2469 C  CA  . GLN   A 1 393 ? -4.74839  -11.31042 -17.87632 1.000 22.14946 ? 393 GLN   A CA  1 
ATOM   2470 C  C   . GLN   A 1 393 ? -5.62145  -10.73086 -16.76308 1.000 21.65206 ? 393 GLN   A C   1 
ATOM   2471 O  O   . GLN   A 1 393 ? -6.65521  -11.31949 -16.42231 1.000 21.35725 ? 393 GLN   A O   1 
ATOM   2472 C  CB  . GLN   A 1 393 ? -3.66167  -12.19547 -17.26458 1.000 22.34944 ? 393 GLN   A CB  1 
ATOM   2473 C  CG  . GLN   A 1 393 ? -4.23069  -13.44646 -16.54379 1.000 23.39419 ? 393 GLN   A CG  1 
ATOM   2474 C  CD  . GLN   A 1 393 ? -5.00331  -14.37722 -17.48448 1.000 28.36986 ? 393 GLN   A CD  1 
ATOM   2475 O  OE1 . GLN   A 1 393 ? -4.46704  -14.84792 -18.48615 1.000 39.78383 ? 393 GLN   A OE1 1 
ATOM   2476 N  NE2 . GLN   A 1 393 ? -6.26949  -14.63861 -17.16479 1.000 27.92827 ? 393 GLN   A NE2 1 
ATOM   2477 N  N   . ASP   A 1 394 ? -5.21863  -9.59781  -16.16902 1.000 20.20904 ? 394 ASP   A N   1 
ATOM   2478 C  CA  . ASP   A 1 394 ? -6.01317  -9.01071  -15.08775 1.000 21.76578 ? 394 ASP   A CA  1 
ATOM   2479 C  C   . ASP   A 1 394 ? -7.33543  -8.46324  -15.61068 1.000 18.20258 ? 394 ASP   A C   1 
ATOM   2480 O  O   . ASP   A 1 394 ? -8.35022  -8.48577  -14.90300 1.000 19.49377 ? 394 ASP   A O   1 
ATOM   2481 C  CB  . ASP   A 1 394 ? -5.24163  -7.88793  -14.38713 1.000 23.58877 ? 394 ASP   A CB  1 
ATOM   2482 C  CG  . ASP   A 1 394 ? -4.00551  -8.38304  -13.64733 1.000 34.18498 ? 394 ASP   A CG  1 
ATOM   2483 O  OD1 . ASP   A 1 394 ? -3.93924  -9.58147  -13.29972 1.000 31.25728 ? 394 ASP   A OD1 1 
ATOM   2484 O  OD2 . ASP   A 1 394 ? -3.09477  -7.56052  -13.40899 1.000 29.69179 ? 394 ASP   A OD2 1 
ATOM   2485 N  N   . ILE   A 1 395 ? -7.32444  -7.92041  -16.82783 1.000 18.27816 ? 395 ILE   A N   1 
ATOM   2486 C  CA  . ILE   A 1 395 ? -8.55278  -7.42710  -17.44663 1.000 16.13705 ? 395 ILE   A CA  1 
ATOM   2487 C  C   . ILE   A 1 395 ? -9.48913  -8.59203  -17.73023 1.000 15.77557 ? 395 ILE   A C   1 
ATOM   2488 O  O   . ILE   A 1 395 ? -10.68450 -8.55003  -17.41686 1.000 13.13980 ? 395 ILE   A O   1 
ATOM   2489 C  CB  . ILE   A 1 395 ? -8.21731  -6.63509  -18.73057 1.000 16.13162 ? 395 ILE   A CB  1 
ATOM   2490 C  CG1 . ILE   A 1 395 ? -7.43750  -5.34653  -18.40702 1.000 14.93173 ? 395 ILE   A CG1 1 
ATOM   2491 C  CG2 . ILE   A 1 395 ? -9.47579  -6.35398  -19.58103 1.000 12.80654 ? 395 ILE   A CG2 1 
ATOM   2492 C  CD1 . ILE   A 1 395 ? -6.87563  -4.65604  -19.66985 1.000 13.32922 ? 395 ILE   A CD1 1 
ATOM   2493 N  N   . LEU   A 1 396 ? -8.95182  -9.66261  -18.32146 1.000 16.70162 ? 396 LEU   A N   1 
ATOM   2494 C  CA  . LEU   A 1 396 ? -9.77873  -10.83616 -18.58192 1.000 13.84380 ? 396 LEU   A CA  1 
ATOM   2495 C  C   . LEU   A 1 396 ? -10.28774 -11.44947 -17.27469 1.000 15.76621 ? 396 LEU   A C   1 
ATOM   2496 O  O   . LEU   A 1 396 ? -11.45135 -11.86631 -17.18922 1.000 18.42855 ? 396 LEU   A O   1 
ATOM   2497 C  CB  . LEU   A 1 396 ? -8.98630  -11.84970 -19.41879 1.000 16.60067 ? 396 LEU   A CB  1 
ATOM   2498 C  CG  . LEU   A 1 396 ? -9.68549  -13.08831 -19.97191 1.000 20.65520 ? 396 LEU   A CG  1 
ATOM   2499 C  CD1 . LEU   A 1 396 ? -10.76929 -12.75576 -21.00229 1.000 16.36435 ? 396 LEU   A CD1 1 
ATOM   2500 C  CD2 . LEU   A 1 396 ? -8.61577  -14.03021 -20.55748 1.000 22.24093 ? 396 LEU   A CD2 1 
ATOM   2501 N  N   . ASP   A 1 397 ? -9.44505  -11.48004 -16.23219 1.000 20.05326 ? 397 ASP   A N   1 
ATOM   2502 C  CA  . ASP   A 1 397 ? -9.89890  -11.98038 -14.93203 1.000 20.56172 ? 397 ASP   A CA  1 
ATOM   2503 C  C   . ASP   A 1 397 ? -11.03864 -11.13116 -14.38452 1.000 19.49166 ? 397 ASP   A C   1 
ATOM   2504 O  O   . ASP   A 1 397 ? -12.00865 -11.66582 -13.83488 1.000 15.63642 ? 397 ASP   A O   1 
ATOM   2505 C  CB  . ASP   A 1 397 ? -8.75435  -12.00065 -13.90805 1.000 23.68070 ? 397 ASP   A CB  1 
ATOM   2506 C  CG  . ASP   A 1 397 ? -7.72232  -13.09331 -14.17405 1.000 26.18522 ? 397 ASP   A CG  1 
ATOM   2507 O  OD1 . ASP   A 1 397 ? -8.02617  -14.08507 -14.86791 1.000 21.73296 ? 397 ASP   A OD1 1 
ATOM   2508 O  OD2 . ASP   A 1 397 ? -6.58172  -12.92653 -13.69813 1.000 26.33708 ? 397 ASP   A OD2 1 
ATOM   2509 N  N   . THR   A 1 398 ? -10.93205 -9.80287  -14.50378 1.000 16.17900 ? 398 THR   A N   1 
ATOM   2510 C  CA  . THR   A 1 398 ? -12.01886 -8.95699  -14.01996 1.000 15.00475 ? 398 THR   A CA  1 
ATOM   2511 C  C   . THR   A 1 398 ? -13.30102 -9.25151  -14.77953 1.000 14.81151 ? 398 THR   A C   1 
ATOM   2512 O  O   . THR   A 1 398 ? -14.36660 -9.39648  -14.17508 1.000 15.95304 ? 398 THR   A O   1 
ATOM   2513 C  CB  . THR   A 1 398 ? -11.63786 -7.47595  -14.14229 1.000 14.00650 ? 398 THR   A CB  1 
ATOM   2514 O  OG1 . THR   A 1 398 ? -10.37912 -7.25727  -13.48728 1.000 19.29926 ? 398 THR   A OG1 1 
ATOM   2515 C  CG2 . THR   A 1 398 ? -12.69746 -6.60181  -13.48474 1.000 18.79526 ? 398 THR   A CG2 1 
ATOM   2516 N  N   . LEU   A 1 399 ? -13.21278 -9.36217  -16.10916 1.000 16.23379 ? 399 LEU   A N   1 
ATOM   2517 C  CA  . LEU   A 1 399 ? -14.38504 -9.69580  -16.91435 1.000 12.08797 ? 399 LEU   A CA  1 
ATOM   2518 C  C   . LEU   A 1 399 ? -15.03629 -10.99278 -16.44097 1.000 15.08817 ? 399 LEU   A C   1 
ATOM   2519 O  O   . LEU   A 1 399 ? -16.26688 -11.08516 -16.32864 1.000 12.40089 ? 399 LEU   A O   1 
ATOM   2520 C  CB  . LEU   A 1 399 ? -13.98921 -9.80195  -18.39068 1.000 11.30511 ? 399 LEU   A CB  1 
ATOM   2521 C  CG  . LEU   A 1 399 ? -15.05275 -10.26773 -19.38348 1.000 12.67312 ? 399 LEU   A CG  1 
ATOM   2522 C  CD1 . LEU   A 1 399 ? -16.18108 -9.23429  -19.48568 1.000 10.20480 ? 399 LEU   A CD1 1 
ATOM   2523 C  CD2 . LEU   A 1 399 ? -14.43035 -10.52561 -20.76007 1.000 12.66177 ? 399 LEU   A CD2 1 
ATOM   2524 N  N   . GLU   A 1 400 ? -14.22805 -12.02029 -16.17831 1.000 16.69140 ? 400 GLU   A N   1 
ATOM   2525 C  CA  . GLU   A 1 400 ? -14.81752 -13.28785 -15.75465 1.000 17.36924 ? 400 GLU   A CA  1 
ATOM   2526 C  C   . GLU   A 1 400 ? -15.47045 -13.16169 -14.38011 1.000 17.38678 ? 400 GLU   A C   1 
ATOM   2527 O  O   . GLU   A 1 400 ? -16.57115 -13.68599 -14.16683 1.000 16.35450 ? 400 GLU   A O   1 
ATOM   2528 C  CB  . GLU   A 1 400 ? -13.75881 -14.39389 -15.79331 1.000 18.00911 ? 400 GLU   A CB  1 
ATOM   2529 C  CG  . GLU   A 1 400 ? -13.47725 -14.85746 -17.22295 1.000 18.60650 ? 400 GLU   A CG  1 
ATOM   2530 C  CD  . GLU   A 1 400 ? -12.18639 -15.67339 -17.36882 1.000 22.20019 ? 400 GLU   A CD  1 
ATOM   2531 O  OE1 . GLU   A 1 400 ? -11.74805 -15.87393 -18.52112 1.000 18.74241 ? 400 GLU   A OE1 1 
ATOM   2532 O  OE2 . GLU   A 1 400 ? -11.60613 -16.09276 -16.34244 1.000 22.55890 ? 400 GLU   A OE2 1 
ATOM   2533 N  N   . ASP   A 1 401 ? -14.84591 -12.42579 -13.45209 1.000 15.17086 ? 401 ASP   A N   1 
ATOM   2534 C  CA  . ASP   A 1 401 ? -15.47672 -12.21066 -12.15140 1.000 16.17561 ? 401 ASP   A CA  1 
ATOM   2535 C  C   . ASP   A 1 401 ? -16.79567 -11.47286 -12.29252 1.000 20.39513 ? 401 ASP   A C   1 
ATOM   2536 O  O   . ASP   A 1 401 ? -17.78254 -11.80266 -11.61498 1.000 17.64729 ? 401 ASP   A O   1 
ATOM   2537 C  CB  . ASP   A 1 401 ? -14.56464 -11.41662 -11.22711 1.000 17.83118 ? 401 ASP   A CB  1 
ATOM   2538 C  CG  . ASP   A 1 401 ? -13.38484 -12.19740 -10.77800 1.000 20.45009 ? 401 ASP   A CG  1 
ATOM   2539 O  OD1 . ASP   A 1 401 ? -13.36621 -13.42271 -11.01084 1.000 19.48722 ? 401 ASP   A OD1 1 
ATOM   2540 O  OD2 . ASP   A 1 401 ? -12.48981 -11.57242 -10.18057 1.000 19.95625 ? 401 ASP   A OD2 1 
ATOM   2541 N  N   . ASN   A 1 402 ? -16.81776 -10.43314 -13.13629 1.000 15.51448 ? 402 ASN   A N   1 
ATOM   2542 C  CA  . ASN   A 1 402 ? -18.03966 -9.65265  -13.29985 1.000 16.79069 ? 402 ASN   A CA  1 
ATOM   2543 C  C   . ASN   A 1 402 ? -19.14407 -10.50530 -13.90531 1.000 15.56556 ? 402 ASN   A C   1 
ATOM   2544 O  O   . ASN   A 1 402 ? -20.32399 -10.34656 -13.56222 1.000 14.46258 ? 402 ASN   A O   1 
ATOM   2545 C  CB  . ASN   A 1 402 ? -17.78299 -8.41125  -14.16827 1.000 14.45015 ? 402 ASN   A CB  1 
ATOM   2546 C  CG  . ASN   A 1 402 ? -16.95926 -7.34888  -13.45306 1.000 15.09933 ? 402 ASN   A CG  1 
ATOM   2547 O  OD1 . ASN   A 1 402 ? -16.86541 -7.35088  -12.22794 1.000 16.24836 ? 402 ASN   A OD1 1 
ATOM   2548 N  ND2 . ASN   A 1 402 ? -16.36147 -6.42919  -14.22091 1.000 15.27089 ? 402 ASN   A ND2 1 
ATOM   2549 N  N   . ARG   A 1 403 ? -18.78288 -11.39515 -14.83303 1.000 14.68213 ? 403 ARG   A N   1 
ATOM   2550 C  CA  . ARG   A 1 403 ? -19.76094 -12.33443 -15.38501 1.000 16.52459 ? 403 ARG   A CA  1 
ATOM   2551 C  C   . ARG   A 1 403 ? -20.33058 -13.22599 -14.28552 1.000 15.40496 ? 403 ARG   A C   1 
ATOM   2552 O  O   . ARG   A 1 403 ? -21.55460 -13.37704 -14.15930 1.000 19.55853 ? 403 ARG   A O   1 
ATOM   2553 C  CB  . ARG   A 1 403 ? -19.10976 -13.17197 -16.49188 1.000 15.91244 ? 403 ARG   A CB  1 
ATOM   2554 C  CG  . ARG   A 1 403 ? -20.08204 -14.00988 -17.34491 1.000 16.69597 ? 403 ARG   A CG  1 
ATOM   2555 C  CD  . ARG   A 1 403 ? -20.32142 -15.41753 -16.75481 1.000 14.66070 ? 403 ARG   A CD  1 
ATOM   2556 N  NE  . ARG   A 1 403 ? -21.16502 -16.21781 -17.64361 1.000 20.74055 ? 403 ARG   A NE  1 
ATOM   2557 C  CZ  . ARG   A 1 403 ? -21.79938 -17.33056 -17.28100 1.000 23.62387 ? 403 ARG   A CZ  1 
ATOM   2558 N  NH1 . ARG   A 1 403 ? -21.70001 -17.77320 -16.03367 1.000 19.22030 ? 403 ARG   A NH1 1 
ATOM   2559 N  NH2 . ARG   A 1 403 ? -22.54919 -17.98490 -18.16165 1.000 19.28047 ? 403 ARG   A NH2 1 
ATOM   2560 N  N   . GLU   A 1 404 ? -19.44793 -13.83349 -13.49074 1.000 18.37007 ? 404 GLU   A N   1 
ATOM   2561 C  CA  . GLU   A 1 404 ? -19.87986 -14.62232 -12.33911 1.000 21.19957 ? 404 GLU   A CA  1 
ATOM   2562 C  C   . GLU   A 1 404 ? -20.80745 -13.81952 -11.43441 1.000 24.50738 ? 404 GLU   A C   1 
ATOM   2563 O  O   . GLU   A 1 404 ? -21.82739 -14.33791 -10.95968 1.000 19.38890 ? 404 GLU   A O   1 
ATOM   2564 C  CB  . GLU   A 1 404 ? -18.65633 -15.10504 -11.55819 1.000 25.14786 ? 404 GLU   A CB  1 
ATOM   2565 C  CG  . GLU   A 1 404 ? -18.85885 -16.41724 -10.82075 1.000 37.10838 ? 404 GLU   A CG  1 
ATOM   2566 C  CD  . GLU   A 1 404 ? -18.15652 -16.45372 -9.47117  1.000 47.29600 ? 404 GLU   A CD  1 
ATOM   2567 O  OE1 . GLU   A 1 404 ? -17.15374 -15.72176 -9.28277  1.000 47.61453 ? 404 GLU   A OE1 1 
ATOM   2568 O  OE2 . GLU   A 1 404 ? -18.61002 -17.22880 -8.59804  1.000 56.57417 ? 404 GLU   A OE2 1 
ATOM   2569 N  N   . TRP   A 1 405 ? -20.48541 -12.54393 -11.19290 1.000 18.80199 ? 405 TRP   A N   1 
ATOM   2570 C  CA  . TRP   A 1 405 ? -21.32771 -11.75341 -10.30090 1.000 16.25215 ? 405 TRP   A CA  1 
ATOM   2571 C  C   . TRP   A 1 405 ? -22.72198 -11.55820 -10.88863 1.000 18.37758 ? 405 TRP   A C   1 
ATOM   2572 O  O   . TRP   A 1 405 ? -23.72565 -11.83969 -10.22210 1.000 21.95375 ? 405 TRP   A O   1 
ATOM   2573 C  CB  . TRP   A 1 405 ? -20.67298 -10.40370 -9.97720  1.000 16.54376 ? 405 TRP   A CB  1 
ATOM   2574 C  CG  . TRP   A 1 405 ? -21.49067 -9.59439  -8.98990  1.000 17.60573 ? 405 TRP   A CG  1 
ATOM   2575 C  CD1 . TRP   A 1 405 ? -21.41132 -9.63048  -7.62134  1.000 14.83807 ? 405 TRP   A CD1 1 
ATOM   2576 C  CD2 . TRP   A 1 405 ? -22.53394 -8.66119  -9.30409  1.000 17.38326 ? 405 TRP   A CD2 1 
ATOM   2577 N  NE1 . TRP   A 1 405 ? -22.34229 -8.77207  -7.07127  1.000 13.90668 ? 405 TRP   A NE1 1 
ATOM   2578 C  CE2 . TRP   A 1 405 ? -23.03146 -8.15709  -8.08176  1.000 13.41937 ? 405 TRP   A CE2 1 
ATOM   2579 C  CE3 . TRP   A 1 405 ? -23.08372 -8.18947  -10.50341 1.000 16.31411 ? 405 TRP   A CE3 1 
ATOM   2580 C  CZ2 . TRP   A 1 405 ? -24.05578 -7.20865  -8.02451  1.000 16.38767 ? 405 TRP   A CZ2 1 
ATOM   2581 C  CZ3 . TRP   A 1 405 ? -24.10122 -7.24676  -10.44490 1.000 15.10081 ? 405 TRP   A CZ3 1 
ATOM   2582 C  CH2 . TRP   A 1 405 ? -24.57545 -6.76848  -9.21144  1.000 16.79996 ? 405 TRP   A CH2 1 
ATOM   2583 N  N   . TYR   A 1 406 ? -22.81499 -11.09428 -12.14174 1.000 16.33261 ? 406 TYR   A N   1 
ATOM   2584 C  CA  . TYR   A 1 406 ? -24.13496 -10.88039 -12.74439 1.000 18.62820 ? 406 TYR   A CA  1 
ATOM   2585 C  C   . TYR   A 1 406 ? -24.94038 -12.18060 -12.79813 1.000 20.56570 ? 406 TYR   A C   1 
ATOM   2586 O  O   . TYR   A 1 406 ? -26.15728 -12.17773 -12.57253 1.000 18.22890 ? 406 TYR   A O   1 
ATOM   2587 C  CB  . TYR   A 1 406 ? -23.99224 -10.27142 -14.14792 1.000 16.62136 ? 406 TYR   A CB  1 
ATOM   2588 C  CG  . TYR   A 1 406 ? -24.17919 -8.76003  -14.18488 1.000 16.49920 ? 406 TYR   A CG  1 
ATOM   2589 C  CD1 . TYR   A 1 406 ? -25.44828 -8.19793  -14.06742 1.000 15.07881 ? 406 TYR   A CD1 1 
ATOM   2590 C  CD2 . TYR   A 1 406 ? -23.09152 -7.89659  -14.31722 1.000 15.12286 ? 406 TYR   A CD2 1 
ATOM   2591 C  CE1 . TYR   A 1 406 ? -25.64056 -6.81146  -14.08883 1.000 16.68809 ? 406 TYR   A CE1 1 
ATOM   2592 C  CE2 . TYR   A 1 406 ? -23.27303 -6.49683  -14.34222 1.000 12.50281 ? 406 TYR   A CE2 1 
ATOM   2593 C  CZ  . TYR   A 1 406 ? -24.55065 -5.96871  -14.23039 1.000 13.98512 ? 406 TYR   A CZ  1 
ATOM   2594 O  OH  . TYR   A 1 406 ? -24.75434 -4.60052  -14.25283 1.000 13.25070 ? 406 TYR   A OH  1 
ATOM   2595 N  N   . GLN   A 1 407 ? -24.26794 -13.30025 -13.07892 1.000 16.82937 ? 407 GLN   A N   1 
ATOM   2596 C  CA  . GLN   A 1 407 ? -24.92670 -14.60246 -13.08666 1.000 23.33711 ? 407 GLN   A CA  1 
ATOM   2597 C  C   . GLN   A 1 407 ? -25.48624 -14.94518 -11.70604 1.000 25.87713 ? 407 GLN   A C   1 
ATOM   2598 O  O   . GLN   A 1 407 ? -26.62623 -15.41349 -11.58759 1.000 22.89518 ? 407 GLN   A O   1 
ATOM   2599 C  CB  . GLN   A 1 407 ? -23.93552 -15.67535 -13.56979 1.000 20.80321 ? 407 GLN   A CB  1 
ATOM   2600 C  CG  . GLN   A 1 407 ? -24.45306 -17.10990 -13.55718 1.000 23.79770 ? 407 GLN   A CG  1 
ATOM   2601 C  CD  . GLN   A 1 407 ? -25.62355 -17.31546 -14.49936 1.000 24.62113 ? 407 GLN   A CD  1 
ATOM   2602 O  OE1 . GLN   A 1 407 ? -25.75240 -16.63201 -15.51103 1.000 21.95724 ? 407 GLN   A OE1 1 
ATOM   2603 N  NE2 . GLN   A 1 407 ? -26.49669 -18.24654 -14.15526 1.000 26.03569 ? 407 GLN   A NE2 1 
ATOM   2604 N  N   . SER   A 1 408 ? -24.71142 -14.68767 -10.64671 1.000 18.86193 ? 408 SER   A N   1 
ATOM   2605 C  CA  . SER   A 1 408 ? -25.17191 -14.99321 -9.29098  1.000 22.27765 ? 408 SER   A CA  1 
ATOM   2606 C  C   . SER   A 1 408 ? -26.42776 -14.21258 -8.90308  1.000 27.00059 ? 408 SER   A C   1 
ATOM   2607 O  O   . SER   A 1 408 ? -27.12310 -14.60821 -7.95875  1.000 30.12807 ? 408 SER   A O   1 
ATOM   2608 C  CB  . SER   A 1 408 ? -24.05636 -14.71443 -8.28109  1.000 23.63313 ? 408 SER   A CB  1 
ATOM   2609 O  OG  . SER   A 1 408 ? -23.93282 -13.32124 -8.03780  1.000 20.20796 ? 408 SER   A OG  1 
ATOM   2610 N  N   . THR   A 1 409 ? -26.73227 -13.11301 -9.59926  1.000 24.63295 ? 409 THR   A N   1 
ATOM   2611 C  CA  . THR   A 1 409 ? -27.92221 -12.31156 -9.33019  1.000 29.29438 ? 409 THR   A CA  1 
ATOM   2612 C  C   . THR   A 1 409 ? -29.10859 -12.70696 -10.20669 1.000 36.18742 ? 409 THR   A C   1 
ATOM   2613 O  O   . THR   A 1 409 ? -29.97560 -11.86474 -10.47376 1.000 36.46638 ? 409 THR   A O   1 
ATOM   2614 C  CB  . THR   A 1 409 ? -27.63125 -10.81663 -9.51664  1.000 29.11315 ? 409 THR   A CB  1 
ATOM   2615 O  OG1 . THR   A 1 409 ? -27.54849 -10.51294 -10.91675 1.000 30.16558 ? 409 THR   A OG1 1 
ATOM   2616 C  CG2 . THR   A 1 409 ? -26.32692 -10.40001 -8.82470  1.000 22.06837 ? 409 THR   A CG2 1 
ATOM   2617 N  N   . ILE   A 1 410 ? -29.16193 -13.94996 -10.68235 1.000 31.28525 ? 410 ILE   A N   1 
ATOM   2618 C  CA  . ILE   A 1 410 ? -30.30466 -14.38592 -11.48090 1.000 38.61058 ? 410 ILE   A CA  1 
ATOM   2619 C  C   . ILE   A 1 410 ? -31.19217 -15.31111 -10.64439 1.000 29.48446 ? 410 ILE   A C   1 
ATOM   2620 O  O   . ILE   A 1 410 ? -30.71969 -16.33112 -10.11580 1.000 38.82108 ? 410 ILE   A O   1 
ATOM   2621 C  CB  . ILE   A 1 410 ? -29.84460 -15.07291 -12.80185 1.000 27.75307 ? 410 ILE   A CB  1 
ATOM   2622 C  CG1 . ILE   A 1 410 ? -29.02820 -14.10474 -13.65963 1.000 27.89981 ? 410 ILE   A CG1 1 
ATOM   2623 C  CG2 . ILE   A 1 410 ? -31.04353 -15.56661 -13.61170 1.000 27.05191 ? 410 ILE   A CG2 1 
ATOM   2624 C  CD1 . ILE   A 1 410 ? -28.60113 -14.69260 -14.97753 1.000 21.72294 ? 410 ILE   A CD1 1 
ATOM   2625 N  N   . ASP   B 1 90  ? -44.85219 12.12096  -81.97303 1.000 50.78374 ? 90  ASP   B N   1 
ATOM   2626 C  CA  . ASP   B 1 90  ? -45.33879 11.51076  -83.21257 1.000 55.11079 ? 90  ASP   B CA  1 
ATOM   2627 C  C   . ASP   B 1 90  ? -44.21642 10.77602  -83.96129 1.000 54.56767 ? 90  ASP   B C   1 
ATOM   2628 O  O   . ASP   B 1 90  ? -44.27482 9.55623   -84.14734 1.000 51.59172 ? 90  ASP   B O   1 
ATOM   2629 C  CB  . ASP   B 1 90  ? -45.97939 12.57243  -84.10842 1.000 61.47734 ? 90  ASP   B CB  1 
ATOM   2630 C  CG  . ASP   B 1 90  ? -45.10790 13.80601  -84.26989 1.000 68.05235 ? 90  ASP   B CG  1 
ATOM   2631 O  OD1 . ASP   B 1 90  ? -45.63290 14.85064  -84.71320 1.000 67.94952 ? 90  ASP   B OD1 1 
ATOM   2632 O  OD2 . ASP   B 1 90  ? -43.89867 13.73173  -83.95610 1.000 65.75954 ? 90  ASP   B OD2 1 
ATOM   2633 N  N   . VAL   B 1 91  ? -43.20912 11.52871  -84.41365 1.000 53.05030 ? 91  VAL   B N   1 
ATOM   2634 C  CA  . VAL   B 1 91  ? -41.92449 10.91966  -84.74537 1.000 52.18850 ? 91  VAL   B CA  1 
ATOM   2635 C  C   . VAL   B 1 91  ? -41.29082 10.33886  -83.48819 1.000 47.88103 ? 91  VAL   B C   1 
ATOM   2636 O  O   . VAL   B 1 91  ? -40.66911 9.26719   -83.51899 1.000 41.32310 ? 91  VAL   B O   1 
ATOM   2637 C  CB  . VAL   B 1 91  ? -40.99680 11.95128  -85.41301 1.000 51.97625 ? 91  VAL   B CB  1 
ATOM   2638 C  CG1 . VAL   B 1 91  ? -39.64564 11.31313  -85.76369 1.000 43.88853 ? 91  VAL   B CG1 1 
ATOM   2639 C  CG2 . VAL   B 1 91  ? -41.66219 12.55580  -86.63604 1.000 52.81777 ? 91  VAL   B CG2 1 
ATOM   2640 N  N   . LEU   B 1 92  ? -41.43173 11.05097  -82.36685 1.000 46.22459 ? 92  LEU   B N   1 
ATOM   2641 C  CA  . LEU   B 1 92  ? -41.05679 10.50444  -81.07030 1.000 41.58643 ? 92  LEU   B CA  1 
ATOM   2642 C  C   . LEU   B 1 92  ? -41.72442 9.15699   -80.84103 1.000 45.45763 ? 92  LEU   B C   1 
ATOM   2643 O  O   . LEU   B 1 92  ? -41.06171 8.17413   -80.49030 1.000 44.90059 ? 92  LEU   B O   1 
ATOM   2644 C  CB  . LEU   B 1 92  ? -41.43534 11.48975  -79.96563 1.000 40.97519 ? 92  LEU   B CB  1 
ATOM   2645 C  CG  . LEU   B 1 92  ? -41.29887 10.98870  -78.52437 1.000 39.50630 ? 92  LEU   B CG  1 
ATOM   2646 C  CD1 . LEU   B 1 92  ? -39.84558 10.65101  -78.21275 1.000 40.86708 ? 92  LEU   B CD1 1 
ATOM   2647 C  CD2 . LEU   B 1 92  ? -41.85021 12.01941  -77.54233 1.000 33.77116 ? 92  LEU   B CD2 1 
ATOM   2648 N  N   . ALA   B 1 93  ? -43.04301 9.08854   -81.06104 1.000 45.20441 ? 93  ALA   B N   1 
ATOM   2649 C  CA  . ALA   B 1 93  ? -43.75045 7.82118   -80.91011 1.000 47.79848 ? 93  ALA   B CA  1 
ATOM   2650 C  C   . ALA   B 1 93  ? -43.15724 6.74876   -81.80994 1.000 43.00286 ? 93  ALA   B C   1 
ATOM   2651 O  O   . ALA   B 1 93  ? -43.14941 5.56619   -81.44911 1.000 43.20455 ? 93  ALA   B O   1 
ATOM   2652 C  CB  . ALA   B 1 93  ? -45.23907 8.00940   -81.20707 1.000 48.62439 ? 93  ALA   B CB  1 
ATOM   2653 N  N   . LYS   B 1 94  ? -42.62305 7.14885   -82.96526 1.000 44.72194 ? 94  LYS   B N   1 
ATOM   2654 C  CA  . LYS   B 1 94  ? -42.04469 6.19461   -83.90321 1.000 47.46217 ? 94  LYS   B CA  1 
ATOM   2655 C  C   . LYS   B 1 94  ? -40.66917 5.70849   -83.44702 1.000 41.18110 ? 94  LYS   B C   1 
ATOM   2656 O  O   . LYS   B 1 94  ? -40.37215 4.51103   -83.53773 1.000 39.56745 ? 94  LYS   B O   1 
ATOM   2657 C  CB  . LYS   B 1 94  ? -41.96873 6.82887   -85.29452 1.000 47.88741 ? 94  LYS   B CB  1 
ATOM   2658 C  CG  . LYS   B 1 94  ? -41.09027 6.07506   -86.27851 1.000 51.84402 ? 94  LYS   B CG  1 
ATOM   2659 C  CD  . LYS   B 1 94  ? -41.56365 4.64489   -86.46321 1.000 46.46600 ? 94  LYS   B CD  1 
ATOM   2660 C  CE  . LYS   B 1 94  ? -41.34999 4.19093   -87.88447 1.000 53.50237 ? 94  LYS   B CE  1 
ATOM   2661 N  NZ  . LYS   B 1 94  ? -40.90874 2.77664   -87.92067 1.000 60.62612 ? 94  LYS   B NZ  1 
ATOM   2662 N  N   . GLU   B 1 95  ? -39.81517 6.61677   -82.96275 1.000 42.44461 ? 95  GLU   B N   1 
ATOM   2663 C  CA  . GLU   B 1 95  ? -38.49267 6.20571   -82.48945 1.000 42.00088 ? 95  GLU   B CA  1 
ATOM   2664 C  C   . GLU   B 1 95  ? -38.60338 5.24415   -81.30993 1.000 38.33575 ? 95  GLU   B C   1 
ATOM   2665 O  O   . GLU   B 1 95  ? -37.81349 4.29839   -81.19153 1.000 37.38052 ? 95  GLU   B O   1 
ATOM   2666 C  CB  . GLU   B 1 95  ? -37.65856 7.43316   -82.10125 1.000 41.86128 ? 95  GLU   B CB  1 
ATOM   2667 C  CG  . GLU   B 1 95  ? -37.37594 8.43548   -83.23081 1.000 42.58501 ? 95  GLU   B CG  1 
ATOM   2668 C  CD  . GLU   B 1 95  ? -36.26612 7.99090   -84.18907 1.000 49.20465 ? 95  GLU   B CD  1 
ATOM   2669 O  OE1 . GLU   B 1 95  ? -35.63163 6.93962   -83.95150 1.000 44.35044 ? 95  GLU   B OE1 1 
ATOM   2670 O  OE2 . GLU   B 1 95  ? -36.02740 8.70256   -85.19069 1.000 57.36753 ? 95  GLU   B OE2 1 
ATOM   2671 N  N   . LEU   B 1 96  ? -39.58921 5.46229   -80.43245 1.000 40.62932 ? 96  LEU   B N   1 
ATOM   2672 C  CA  . LEU   B 1 96  ? -39.75639 4.61165   -79.25656 1.000 38.71915 ? 96  LEU   B CA  1 
ATOM   2673 C  C   . LEU   B 1 96  ? -40.12609 3.17868   -79.61408 1.000 42.35046 ? 96  LEU   B C   1 
ATOM   2674 O  O   . LEU   B 1 96  ? -39.97686 2.28890   -78.76971 1.000 40.56385 ? 96  LEU   B O   1 
ATOM   2675 C  CB  . LEU   B 1 96  ? -40.80664 5.21178   -78.32403 1.000 37.15371 ? 96  LEU   B CB  1 
ATOM   2676 C  CG  . LEU   B 1 96  ? -40.33328 6.49972   -77.65238 1.000 39.37430 ? 96  LEU   B CG  1 
ATOM   2677 C  CD1 . LEU   B 1 96  ? -41.50216 7.31179   -77.10784 1.000 38.50669 ? 96  LEU   B CD1 1 
ATOM   2678 C  CD2 . LEU   B 1 96  ? -39.31984 6.18019   -76.54014 1.000 35.26140 ? 96  LEU   B CD2 1 
ATOM   2679 N  N   . GLU   B 1 97  ? -40.58077 2.92803   -80.84668 1.000 39.59201 ? 97  GLU   B N   1 
ATOM   2680 C  CA  . GLU   B 1 97  ? -40.85426 1.56321   -81.27726 1.000 40.45732 ? 97  GLU   B CA  1 
ATOM   2681 C  C   . GLU   B 1 97  ? -39.61606 0.68766   -81.24537 1.000 38.47223 ? 97  GLU   B C   1 
ATOM   2682 O  O   . GLU   B 1 97  ? -39.74437 -0.53889  -81.32692 1.000 38.22005 ? 97  GLU   B O   1 
ATOM   2683 C  CB  . GLU   B 1 97  ? -41.44864 1.55503   -82.68751 1.000 45.25400 ? 97  GLU   B CB  1 
ATOM   2684 C  CG  . GLU   B 1 97  ? -42.69276 2.39956   -82.84448 1.000 39.09336 ? 97  GLU   B CG  1 
ATOM   2685 C  CD  . GLU   B 1 97  ? -43.42513 2.10408   -84.14547 1.000 50.92126 ? 97  GLU   B CD  1 
ATOM   2686 O  OE1 . GLU   B 1 97  ? -43.58285 0.90718   -84.47123 1.000 52.51934 ? 97  GLU   B OE1 1 
ATOM   2687 O  OE2 . GLU   B 1 97  ? -43.84218 3.05966   -84.83820 1.000 48.66420 ? 97  GLU   B OE2 1 
ATOM   2688 N  N   . ASP   B 1 98  ? -38.42911 1.28362   -81.13099 1.000 39.74922 ? 98  ASP   B N   1 
ATOM   2689 C  CA  . ASP   B 1 98  ? -37.17305 0.55481   -81.02060 1.000 38.09382 ? 98  ASP   B CA  1 
ATOM   2690 C  C   . ASP   B 1 98  ? -36.74871 0.32704   -79.56923 1.000 36.70386 ? 98  ASP   B C   1 
ATOM   2691 O  O   . ASP   B 1 98  ? -35.60806 -0.08846  -79.32397 1.000 28.73454 ? 98  ASP   B O   1 
ATOM   2692 C  CB  . ASP   B 1 98  ? -36.07202 1.30191   -81.77991 1.000 39.96630 ? 98  ASP   B CB  1 
ATOM   2693 C  CG  . ASP   B 1 98  ? -36.23421 1.21292   -83.29113 1.000 42.95838 ? 98  ASP   B CG  1 
ATOM   2694 O  OD1 . ASP   B 1 98  ? -37.31909 0.80658   -83.75733 1.000 42.08008 ? 98  ASP   B OD1 1 
ATOM   2695 O  OD2 . ASP   B 1 98  ? -35.27097 1.55036   -84.01259 1.000 47.54038 ? 98  ASP   B OD2 1 
ATOM   2696 N  N   . VAL   B 1 99  ? -37.65196 0.55904   -78.61128 1.000 36.10386 ? 99  VAL   B N   1 
ATOM   2697 C  CA  . VAL   B 1 99  ? -37.30568 0.49436   -77.19514 1.000 31.55378 ? 99  VAL   B CA  1 
ATOM   2698 C  C   . VAL   B 1 99  ? -36.72668 -0.85438  -76.79608 1.000 35.64644 ? 99  VAL   B C   1 
ATOM   2699 O  O   . VAL   B 1 99  ? -35.98194 -0.93614  -75.81214 1.000 35.42424 ? 99  VAL   B O   1 
ATOM   2700 C  CB  . VAL   B 1 99  ? -38.54196 0.85205   -76.34382 1.000 34.40217 ? 99  VAL   B CB  1 
ATOM   2701 C  CG1 . VAL   B 1 99  ? -39.54887 -0.29787  -76.32494 1.000 37.49479 ? 99  VAL   B CG1 1 
ATOM   2702 C  CG2 . VAL   B 1 99  ? -38.12628 1.28081   -74.93975 1.000 33.74642 ? 99  VAL   B CG2 1 
ATOM   2703 N  N   . ASN   B 1 100 ? -37.01590 -1.91437  -77.54849 1.000 31.28346 ? 100 ASN   B N   1 
ATOM   2704 C  CA  . ASN   B 1 100 ? -36.46747 -3.22855  -77.24504 1.000 31.58823 ? 100 ASN   B CA  1 
ATOM   2705 C  C   . ASN   B 1 100 ? -35.18636 -3.53378  -78.00919 1.000 32.46840 ? 100 ASN   B C   1 
ATOM   2706 O  O   . ASN   B 1 100 ? -34.68817 -4.66011  -77.92322 1.000 31.11983 ? 100 ASN   B O   1 
ATOM   2707 C  CB  . ASN   B 1 100 ? -37.49654 -4.32957  -77.54256 1.000 38.29992 ? 100 ASN   B CB  1 
ATOM   2708 C  CG  . ASN   B 1 100 ? -38.76863 -4.19870  -76.71296 1.000 42.97522 ? 100 ASN   B CG  1 
ATOM   2709 O  OD1 . ASN   B 1 100 ? -38.82609 -3.45058  -75.73011 1.000 38.39011 ? 100 ASN   B OD1 1 
ATOM   2710 N  ND2 . ASN   B 1 100 ? -39.80015 -4.93748  -77.10915 1.000 41.08560 ? 100 ASN   B ND2 1 
ATOM   2711 N  N   . LYS   B 1 101 ? -34.63619 -2.57570  -78.74537 1.000 33.29482 ? 101 LYS   B N   1 
ATOM   2712 C  CA  . LYS   B 1 101 ? -33.49749 -2.83569  -79.61267 1.000 33.88780 ? 101 LYS   B CA  1 
ATOM   2713 C  C   . LYS   B 1 101 ? -32.23251 -2.16443  -79.09053 1.000 28.98945 ? 101 LYS   B C   1 
ATOM   2714 O  O   . LYS   B 1 101 ? -32.25676 -1.00601  -78.65827 1.000 26.24345 ? 101 LYS   B O   1 
ATOM   2715 C  CB  . LYS   B 1 101 ? -33.77988 -2.36992  -81.04286 1.000 34.38605 ? 101 LYS   B CB  1 
ATOM   2716 C  CG  . LYS   B 1 101 ? -34.94809 -3.09645  -81.71054 1.000 40.69758 ? 101 LYS   B CG  1 
ATOM   2717 C  CD  . LYS   B 1 101 ? -35.53283 -2.25579  -82.82612 1.000 40.31258 ? 101 LYS   B CD  1 
ATOM   2718 C  CE  . LYS   B 1 101 ? -36.82365 -2.83092  -83.36044 1.000 39.31367 ? 101 LYS   B CE  1 
ATOM   2719 N  NZ  . LYS   B 1 101 ? -37.64830 -1.73773  -83.94060 1.000 44.34635 ? 101 LYS   B NZ  1 
ATOM   2720 N  N   . TRP   B 1 102 ? -31.13874 -2.91977  -79.14106 1.000 25.24985 ? 102 TRP   B N   1 
ATOM   2721 C  CA  . TRP   B 1 102 ? -29.80497 -2.39915  -78.88433 1.000 25.91648 ? 102 TRP   B CA  1 
ATOM   2722 C  C   . TRP   B 1 102 ? -29.41041 -1.41553  -79.97830 1.000 32.64765 ? 102 TRP   B C   1 
ATOM   2723 O  O   . TRP   B 1 102 ? -29.43657 -1.74931  -81.16854 1.000 32.62737 ? 102 TRP   B O   1 
ATOM   2724 C  CB  . TRP   B 1 102 ? -28.81777 -3.55698  -78.84117 1.000 25.94791 ? 102 TRP   B CB  1 
ATOM   2725 C  CG  . TRP   B 1 102 ? -27.56229 -3.31490  -78.06451 1.000 27.69661 ? 102 TRP   B CG  1 
ATOM   2726 C  CD1 . TRP   B 1 102 ? -26.31133 -3.10651  -78.56919 1.000 27.58869 ? 102 TRP   B CD1 1 
ATOM   2727 C  CD2 . TRP   B 1 102 ? -27.42597 -3.30666  -76.63972 1.000 27.29498 ? 102 TRP   B CD2 1 
ATOM   2728 N  NE1 . TRP   B 1 102 ? -25.40498 -2.95954  -77.54672 1.000 25.18392 ? 102 TRP   B NE1 1 
ATOM   2729 C  CE2 . TRP   B 1 102 ? -26.06593 -3.07636  -76.35145 1.000 26.72685 ? 102 TRP   B CE2 1 
ATOM   2730 C  CE3 . TRP   B 1 102 ? -28.32352 -3.46599  -75.57911 1.000 26.50907 ? 102 TRP   B CE3 1 
ATOM   2731 C  CZ2 . TRP   B 1 102 ? -25.58210 -2.99771  -75.04355 1.000 24.89188 ? 102 TRP   B CZ2 1 
ATOM   2732 C  CZ3 . TRP   B 1 102 ? -27.84205 -3.38186  -74.28111 1.000 24.56334 ? 102 TRP   B CZ3 1 
ATOM   2733 C  CH2 . TRP   B 1 102 ? -26.48663 -3.14987  -74.02556 1.000 23.80760 ? 102 TRP   B CH2 1 
ATOM   2734 N  N   . GLY   B 1 103 ? -29.03070 -0.20892  -79.58052 1.000 29.85667 ? 103 GLY   B N   1 
ATOM   2735 C  CA  . GLY   B 1 103 ? -28.78500 0.85606   -80.52661 1.000 25.33040 ? 103 GLY   B CA  1 
ATOM   2736 C  C   . GLY   B 1 103 ? -29.95222 1.78776   -80.73743 1.000 31.13237 ? 103 GLY   B C   1 
ATOM   2737 O  O   . GLY   B 1 103 ? -30.01490 2.44810   -81.77915 1.000 23.65883 ? 103 GLY   B O   1 
ATOM   2738 N  N   . LEU   B 1 104 ? -30.88871 1.84047   -79.79532 1.000 30.24003 ? 104 LEU   B N   1 
ATOM   2739 C  CA  . LEU   B 1 104 ? -31.96817 2.81302   -79.83418 1.000 26.30171 ? 104 LEU   B CA  1 
ATOM   2740 C  C   . LEU   B 1 104 ? -31.42210 4.21160   -80.10574 1.000 33.83360 ? 104 LEU   B C   1 
ATOM   2741 O  O   . LEU   B 1 104 ? -30.31053 4.55626   -79.69418 1.000 32.71036 ? 104 LEU   B O   1 
ATOM   2742 C  CB  . LEU   B 1 104 ? -32.72548 2.78426   -78.49943 1.000 29.68068 ? 104 LEU   B CB  1 
ATOM   2743 C  CG  . LEU   B 1 104 ? -33.78430 3.86066   -78.30926 1.000 32.09937 ? 104 LEU   B CG  1 
ATOM   2744 C  CD1 . LEU   B 1 104 ? -35.05350 3.49842   -79.07427 1.000 32.78775 ? 104 LEU   B CD1 1 
ATOM   2745 C  CD2 . LEU   B 1 104 ? -34.05592 4.10749   -76.83108 1.000 25.95626 ? 104 LEU   B CD2 1 
ATOM   2746 N  N   . HIS   B 1 105 ? -32.22109 5.03073   -80.79434 1.000 29.86243 ? 105 HIS   B N   1 
ATOM   2747 C  CA  . HIS   B 1 105 ? -31.79869 6.36952   -81.22146 1.000 32.46356 ? 105 HIS   B CA  1 
ATOM   2748 C  C   . HIS   B 1 105 ? -32.03773 7.37152   -80.08608 1.000 28.18412 ? 105 HIS   B C   1 
ATOM   2749 O  O   . HIS   B 1 105 ? -32.87487 8.27346   -80.15663 1.000 29.19948 ? 105 HIS   B O   1 
ATOM   2750 C  CB  . HIS   B 1 105 ? -32.52934 6.75363   -82.50372 1.000 40.89805 ? 105 HIS   B CB  1 
ATOM   2751 C  CG  . HIS   B 1 105 ? -32.06150 5.99398   -83.71190 1.000 42.22085 ? 105 HIS   B CG  1 
ATOM   2752 N  ND1 . HIS   B 1 105 ? -32.83017 5.83956   -84.84711 1.000 49.62278 ? 105 HIS   B ND1 1 
ATOM   2753 C  CD2 . HIS   B 1 105 ? -30.89641 5.35005   -83.95951 1.000 40.98825 ? 105 HIS   B CD2 1 
ATOM   2754 C  CE1 . HIS   B 1 105 ? -32.16213 5.12524   -85.73583 1.000 38.99270 ? 105 HIS   B CE1 1 
ATOM   2755 N  NE2 . HIS   B 1 105 ? -30.98405 4.82011   -85.22338 1.000 46.30699 ? 105 HIS   B NE2 1 
ATOM   2756 N  N   . VAL   B 1 106 ? -31.24225 7.21277   -79.02309 1.000 27.38756 ? 106 VAL   B N   1 
ATOM   2757 C  CA  . VAL   B 1 106 ? -31.51275 7.91853   -77.76840 1.000 23.96101 ? 106 VAL   B CA  1 
ATOM   2758 C  C   . VAL   B 1 106 ? -31.24794 9.42190   -77.88406 1.000 23.91222 ? 106 VAL   B C   1 
ATOM   2759 O  O   . VAL   B 1 106 ? -31.92025 10.22558  -77.22460 1.000 22.87063 ? 106 VAL   B O   1 
ATOM   2760 C  CB  . VAL   B 1 106 ? -30.71010 7.28354   -76.61332 1.000 25.55431 ? 106 VAL   B CB  1 
ATOM   2761 C  CG1 . VAL   B 1 106 ? -29.20060 7.40506   -76.85309 1.000 23.70914 ? 106 VAL   B CG1 1 
ATOM   2762 C  CG2 . VAL   B 1 106 ? -31.10033 7.91077   -75.27428 1.000 22.92071 ? 106 VAL   B CG2 1 
ATOM   2763 N  N   . PHE   B 1 107 ? -30.29643 9.84594   -78.72068 1.000 24.47782 ? 107 PHE   B N   1 
ATOM   2764 C  CA  . PHE   B 1 107 ? -30.10169 11.28359  -78.88892 1.000 23.73602 ? 107 PHE   B CA  1 
ATOM   2765 C  C   . PHE   B 1 107 ? -31.26914 11.91078  -79.63988 1.000 26.86095 ? 107 PHE   B C   1 
ATOM   2766 O  O   . PHE   B 1 107 ? -31.72619 13.00207  -79.27992 1.000 29.44353 ? 107 PHE   B O   1 
ATOM   2767 C  CB  . PHE   B 1 107 ? -28.77388 11.55939  -79.58874 1.000 26.08943 ? 107 PHE   B CB  1 
ATOM   2768 C  CG  . PHE   B 1 107 ? -27.58432 11.16749  -78.76842 1.000 27.96175 ? 107 PHE   B CG  1 
ATOM   2769 C  CD1 . PHE   B 1 107 ? -27.16680 11.95869  -77.71234 1.000 26.77791 ? 107 PHE   B CD1 1 
ATOM   2770 C  CD2 . PHE   B 1 107 ? -26.90165 9.99758   -79.03460 1.000 24.77195 ? 107 PHE   B CD2 1 
ATOM   2771 C  CE1 . PHE   B 1 107 ? -26.07731 11.58991  -76.93845 1.000 24.66628 ? 107 PHE   B CE1 1 
ATOM   2772 C  CE2 . PHE   B 1 107 ? -25.81862 9.62401   -78.27838 1.000 24.97821 ? 107 PHE   B CE2 1 
ATOM   2773 C  CZ  . PHE   B 1 107 ? -25.40428 10.41623  -77.21850 1.000 23.03583 ? 107 PHE   B CZ  1 
ATOM   2774 N  N   . ARG   B 1 108 ? -31.76574 11.22950  -80.67839 1.000 30.81922 ? 108 ARG   B N   1 
ATOM   2775 C  CA  . ARG   B 1 108 ? -32.99112 11.66035  -81.34547 1.000 34.91033 ? 108 ARG   B CA  1 
ATOM   2776 C  C   . ARG   B 1 108 ? -34.13760 11.80138  -80.35819 1.000 31.72101 ? 108 ARG   B C   1 
ATOM   2777 O  O   . ARG   B 1 108 ? -34.82693 12.82704  -80.33435 1.000 31.56802 ? 108 ARG   B O   1 
ATOM   2778 C  CB  . ARG   B 1 108 ? -33.37077 10.66673  -82.44502 1.000 40.66524 ? 108 ARG   B CB  1 
ATOM   2779 C  CG  . ARG   B 1 108 ? -32.47024 10.68624  -83.66769 1.000 48.87694 ? 108 ARG   B CG  1 
ATOM   2780 C  CD  . ARG   B 1 108 ? -32.56514 12.03021  -84.38479 1.000 58.64204 ? 108 ARG   B CD  1 
ATOM   2781 N  NE  . ARG   B 1 108 ? -33.89113 12.29984  -84.95089 1.000 64.34036 ? 108 ARG   B NE  1 
ATOM   2782 C  CZ  . ARG   B 1 108 ? -34.41976 13.51842  -85.12744 1.000 69.69553 ? 108 ARG   B CZ  1 
ATOM   2783 N  NH1 . ARG   B 1 108 ? -33.73035 14.60345  -84.74751 1.000 69.98553 ? 108 ARG   B NH1 1 
ATOM   2784 N  NH2 . ARG   B 1 108 ? -35.62030 13.64786  -85.65507 1.000 72.95553 ? 108 ARG   B NH2 1 
ATOM   2785 N  N   . ILE   B 1 109 ? -34.34357 10.77790  -79.52962 1.000 30.18453 ? 109 ILE   B N   1 
ATOM   2786 C  CA  . ILE   B 1 109 ? -35.44725 10.78798  -78.57707 1.000 28.96465 ? 109 ILE   B CA  1 
ATOM   2787 C  C   . ILE   B 1 109 ? -35.27774 11.92479  -77.58074 1.000 27.46342 ? 109 ILE   B C   1 
ATOM   2788 O  O   . ILE   B 1 109 ? -36.25277 12.58031  -77.19218 1.000 29.60489 ? 109 ILE   B O   1 
ATOM   2789 C  CB  . ILE   B 1 109 ? -35.55265 9.41002   -77.89658 1.000 31.28036 ? 109 ILE   B CB  1 
ATOM   2790 C  CG1 . ILE   B 1 109 ? -36.12398 8.40423   -78.90461 1.000 30.01191 ? 109 ILE   B CG1 1 
ATOM   2791 C  CG2 . ILE   B 1 109 ? -36.38508 9.47775   -76.62494 1.000 27.40792 ? 109 ILE   B CG2 1 
ATOM   2792 C  CD1 . ILE   B 1 109 ? -35.83569 6.97591   -78.59365 1.000 29.86268 ? 109 ILE   B CD1 1 
ATOM   2793 N  N   . ALA   B 1 110 ? -34.03210 12.21727  -77.19587 1.000 31.45375 ? 110 ALA   B N   1 
ATOM   2794 C  CA  . ALA   B 1 110 ? -33.77962 13.35757  -76.32132 1.000 24.10604 ? 110 ALA   B CA  1 
ATOM   2795 C  C   . ALA   B 1 110 ? -34.19227 14.65856  -76.99686 1.000 31.21618 ? 110 ALA   B C   1 
ATOM   2796 O  O   . ALA   B 1 110 ? -34.85392 15.50508  -76.38528 1.000 30.44860 ? 110 ALA   B O   1 
ATOM   2797 C  CB  . ALA   B 1 110 ? -32.30252 13.39830  -75.91566 1.000 28.24799 ? 110 ALA   B CB  1 
ATOM   2798 N  N   . GLU   B 1 111 ? -33.80948 14.82868  -78.26824 1.000 33.26508 ? 111 GLU   B N   1 
ATOM   2799 C  CA  . GLU   B 1 111 ? -34.20408 16.01082  -79.02914 1.000 34.33040 ? 111 GLU   B CA  1 
ATOM   2800 C  C   . GLU   B 1 111 ? -35.72132 16.10197  -79.14964 1.000 34.26059 ? 111 GLU   B C   1 
ATOM   2801 O  O   . GLU   B 1 111 ? -36.32113 17.14155  -78.84778 1.000 34.80967 ? 111 GLU   B O   1 
ATOM   2802 C  CB  . GLU   B 1 111 ? -33.56143 15.97742  -80.42369 1.000 37.27313 ? 111 GLU   B CB  1 
ATOM   2803 C  CG  . GLU   B 1 111 ? -32.08561 16.38844  -80.48791 1.000 42.87418 ? 111 GLU   B CG  1 
ATOM   2804 C  CD  . GLU   B 1 111 ? -31.36662 15.88768  -81.74974 1.000 49.72637 ? 111 GLU   B CD  1 
ATOM   2805 O  OE1 . GLU   B 1 111 ? -30.16418 16.20008  -81.89950 1.000 50.00461 ? 111 GLU   B OE1 1 
ATOM   2806 O  OE2 . GLU   B 1 111 ? -31.98429 15.17172  -82.57753 1.000 48.38392 ? 111 GLU   B OE2 1 
ATOM   2807 N  N   . LEU   B 1 112 ? -36.35882 15.01171  -79.58230 1.000 29.51249 ? 112 LEU   B N   1 
ATOM   2808 C  CA  . LEU   B 1 112 ? -37.78763 15.01810  -79.88157 1.000 32.33288 ? 112 LEU   B CA  1 
ATOM   2809 C  C   . LEU   B 1 112 ? -38.67842 15.09663  -78.64472 1.000 37.04788 ? 112 LEU   B C   1 
ATOM   2810 O  O   . LEU   B 1 112 ? -39.87504 15.36201  -78.79540 1.000 35.82084 ? 112 LEU   B O   1 
ATOM   2811 C  CB  . LEU   B 1 112 ? -38.15581 13.76924  -80.67985 1.000 32.03003 ? 112 LEU   B CB  1 
ATOM   2812 C  CG  . LEU   B 1 112 ? -37.53355 13.63117  -82.06523 1.000 36.68923 ? 112 LEU   B CG  1 
ATOM   2813 C  CD1 . LEU   B 1 112 ? -37.69937 12.20791  -82.57275 1.000 37.13766 ? 112 LEU   B CD1 1 
ATOM   2814 C  CD2 . LEU   B 1 112 ? -38.18075 14.62114  -83.01260 1.000 38.11504 ? 112 LEU   B CD2 1 
ATOM   2815 N  N   . SER   B 1 113 ? -38.15294 14.85488  -77.44089 1.000 30.08537 ? 113 SER   B N   1 
ATOM   2816 C  CA  . SER   B 1 113 ? -38.97455 14.85279  -76.23620 1.000 32.21719 ? 113 SER   B CA  1 
ATOM   2817 C  C   . SER   B 1 113 ? -38.86819 16.14789  -75.44386 1.000 33.42272 ? 113 SER   B C   1 
ATOM   2818 O  O   . SER   B 1 113 ? -39.46218 16.24997  -74.36528 1.000 33.01838 ? 113 SER   B O   1 
ATOM   2819 C  CB  . SER   B 1 113 ? -38.61136 13.66462  -75.33467 1.000 33.90593 ? 113 SER   B CB  1 
ATOM   2820 O  OG  . SER   B 1 113 ? -37.32186 13.82873  -74.76152 1.000 27.89247 ? 113 SER   B OG  1 
ATOM   2821 N  N   . GLY   B 1 114 ? -38.14211 17.13942  -75.95089 1.000 31.02599 ? 114 GLY   B N   1 
ATOM   2822 C  CA  . GLY   B 1 114 ? -37.94665 18.35706  -75.18435 1.000 30.25066 ? 114 GLY   B CA  1 
ATOM   2823 C  C   . GLY   B 1 114 ? -36.95557 18.18002  -74.05442 1.000 33.68837 ? 114 GLY   B C   1 
ATOM   2824 O  O   . GLY   B 1 114 ? -37.15810 18.72626  -72.96036 1.000 34.27885 ? 114 GLY   B O   1 
ATOM   2825 N  N   . ASN   B 1 115 ? -35.88420 17.42493  -74.30016 1.000 32.73930 ? 115 ASN   B N   1 
ATOM   2826 C  CA  . ASN   B 1 115 ? -34.89589 17.06057  -73.28144 1.000 35.11180 ? 115 ASN   B CA  1 
ATOM   2827 C  C   . ASN   B 1 115 ? -35.54037 16.27138  -72.14224 1.000 31.09644 ? 115 ASN   B C   1 
ATOM   2828 O  O   . ASN   B 1 115 ? -35.28608 16.51730  -70.96356 1.000 28.35295 ? 115 ASN   B O   1 
ATOM   2829 C  CB  . ASN   B 1 115 ? -34.14967 18.28604  -72.74471 1.000 30.79263 ? 115 ASN   B CB  1 
ATOM   2830 C  CG  . ASN   B 1 115 ? -32.74942 17.93313  -72.23946 1.000 38.53434 ? 115 ASN   B CG  1 
ATOM   2831 O  OD1 . ASN   B 1 115 ? -32.18988 16.89686  -72.61610 1.000 30.39939 ? 115 ASN   B OD1 1 
ATOM   2832 N  ND2 . ASN   B 1 115 ? -32.18375 18.78759  -71.38236 1.000 33.93161 ? 115 ASN   B ND2 1 
ATOM   2833 N  N   . ARG   B 1 116 ? -36.39124 15.31146  -72.49773 1.000 31.30152 ? 116 ARG   B N   1 
ATOM   2834 C  CA  . ARG   B 1 116 ? -36.99564 14.41047  -71.51527 1.000 27.02422 ? 116 ARG   B CA  1 
ATOM   2835 C  C   . ARG   B 1 116 ? -36.83530 12.94418  -71.91260 1.000 24.69016 ? 116 ARG   B C   1 
ATOM   2836 O  O   . ARG   B 1 116 ? -37.77128 12.15533  -71.78093 1.000 27.67600 ? 116 ARG   B O   1 
ATOM   2837 C  CB  . ARG   B 1 116 ? -38.47112 14.75097  -71.32731 1.000 25.81184 ? 116 ARG   B CB  1 
ATOM   2838 C  CG  . ARG   B 1 116 ? -38.72314 16.11032  -70.68404 1.000 30.44076 ? 116 ARG   B CG  1 
ATOM   2839 C  CD  . ARG   B 1 116 ? -38.09277 16.20394  -69.29080 1.000 30.81899 ? 116 ARG   B CD  1 
ATOM   2840 N  NE  . ARG   B 1 116 ? -38.51383 17.40715  -68.57390 1.000 34.88755 ? 116 ARG   B NE  1 
ATOM   2841 C  CZ  . ARG   B 1 116 ? -38.30818 17.61833  -67.27626 1.000 30.80246 ? 116 ARG   B CZ  1 
ATOM   2842 N  NH1 . ARG   B 1 116 ? -37.68631 16.70395  -66.54461 1.000 26.78697 ? 116 ARG   B NH1 1 
ATOM   2843 N  NH2 . ARG   B 1 116 ? -38.72178 18.74474  -66.71159 1.000 26.85992 ? 116 ARG   B NH2 1 
ATOM   2844 N  N   . PRO   B 1 117 ? -35.64625 12.52826  -72.37533 1.000 25.69048 ? 117 PRO   B N   1 
ATOM   2845 C  CA  . PRO   B 1 117 ? -35.50312 11.11435  -72.75106 1.000 21.47225 ? 117 PRO   B CA  1 
ATOM   2846 C  C   . PRO   B 1 117 ? -35.65573 10.17535  -71.56910 1.000 23.42362 ? 117 PRO   B C   1 
ATOM   2847 O  O   . PRO   B 1 117 ? -36.16508 9.06377   -71.74785 1.000 21.72871 ? 117 PRO   B O   1 
ATOM   2848 C  CB  . PRO   B 1 117 ? -34.09245 11.04302  -73.34837 1.000 22.06418 ? 117 PRO   B CB  1 
ATOM   2849 C  CG  . PRO   B 1 117 ? -33.35090 12.10505  -72.63022 1.000 22.21293 ? 117 PRO   B CG  1 
ATOM   2850 C  CD  . PRO   B 1 117 ? -34.33765 13.21603  -72.39449 1.000 25.08246 ? 117 PRO   B CD  1 
ATOM   2851 N  N   . LEU   B 1 118 ? -35.22809 10.57921  -70.36906 1.000 22.64256 ? 118 LEU   B N   1 
ATOM   2852 C  CA  . LEU   B 1 118 ? -35.37203 9.69161   -69.22064 1.000 20.34604 ? 118 LEU   B CA  1 
ATOM   2853 C  C   . LEU   B 1 118 ? -36.84458 9.47594   -68.90416 1.000 21.76388 ? 118 LEU   B C   1 
ATOM   2854 O  O   . LEU   B 1 118 ? -37.29787 8.33432   -68.75804 1.000 24.58715 ? 118 LEU   B O   1 
ATOM   2855 C  CB  . LEU   B 1 118 ? -34.62378 10.24305  -68.00149 1.000 17.83956 ? 118 LEU   B CB  1 
ATOM   2856 C  CG  . LEU   B 1 118 ? -34.63132 9.35139   -66.74195 1.000 16.18273 ? 118 LEU   B CG  1 
ATOM   2857 C  CD1 . LEU   B 1 118 ? -34.10346 7.95800   -67.02834 1.000 16.16369 ? 118 LEU   B CD1 1 
ATOM   2858 C  CD2 . LEU   B 1 118 ? -33.85197 9.97825   -65.58119 1.000 15.60066 ? 118 LEU   B CD2 1 
ATOM   2859 N  N   . THR   B 1 119 ? -37.61475 10.56225  -68.83769 1.000 24.41903 ? 119 THR   B N   1 
ATOM   2860 C  CA  . THR   B 1 119 ? -39.03907 10.43955  -68.53521 1.000 24.39197 ? 119 THR   B CA  1 
ATOM   2861 C  C   . THR   B 1 119 ? -39.76336 9.59387   -69.58488 1.000 25.87320 ? 119 THR   B C   1 
ATOM   2862 O  O   . THR   B 1 119 ? -40.48899 8.65282   -69.23959 1.000 28.60360 ? 119 THR   B O   1 
ATOM   2863 C  CB  . THR   B 1 119 ? -39.67094 11.82208  -68.40308 1.000 22.76090 ? 119 THR   B CB  1 
ATOM   2864 O  OG1 . THR   B 1 119 ? -39.14021 12.48213  -67.24709 1.000 28.57792 ? 119 THR   B OG1 1 
ATOM   2865 C  CG2 . THR   B 1 119 ? -41.17719 11.70847  -68.23151 1.000 27.08086 ? 119 THR   B CG2 1 
ATOM   2866 N  N   . VAL   B 1 120 ? -39.54986 9.87837   -70.87513 1.000 28.82588 ? 120 VAL   B N   1 
ATOM   2867 C  CA  . VAL   B 1 120 ? -40.32777 9.15719   -71.88388 1.000 25.96513 ? 120 VAL   B CA  1 
ATOM   2868 C  C   . VAL   B 1 120 ? -39.84687 7.71897   -72.04779 1.000 26.08322 ? 120 VAL   B C   1 
ATOM   2869 O  O   . VAL   B 1 120 ? -40.65694 6.82283   -72.31269 1.000 29.48125 ? 120 VAL   B O   1 
ATOM   2870 C  CB  . VAL   B 1 120 ? -40.33895 9.90769   -73.23325 1.000 29.46032 ? 120 VAL   B CB  1 
ATOM   2871 C  CG1 . VAL   B 1 120 ? -40.88866 11.31477  -73.04678 1.000 28.55647 ? 120 VAL   B CG1 1 
ATOM   2872 C  CG2 . VAL   B 1 120 ? -38.95609 9.95321   -73.86230 1.000 30.86457 ? 120 VAL   B CG2 1 
ATOM   2873 N  N   . ILE   B 1 121 ? -38.55047 7.44978   -71.88308 1.000 24.52141 ? 121 ILE   B N   1 
ATOM   2874 C  CA  . ILE   B 1 121 ? -38.08205 6.08088   -72.06570 1.000 23.49890 ? 121 ILE   B CA  1 
ATOM   2875 C  C   . ILE   B 1 121 ? -38.46495 5.21476   -70.86757 1.000 28.12308 ? 121 ILE   B C   1 
ATOM   2876 O  O   . ILE   B 1 121 ? -38.85659 4.05349   -71.03263 1.000 28.43791 ? 121 ILE   B O   1 
ATOM   2877 C  CB  . ILE   B 1 121 ? -36.56299 6.07220   -72.34582 1.000 21.74813 ? 121 ILE   B CB  1 
ATOM   2878 C  CG1 . ILE   B 1 121 ? -36.29703 6.56531   -73.78288 1.000 28.51844 ? 121 ILE   B CG1 1 
ATOM   2879 C  CG2 . ILE   B 1 121 ? -35.96400 4.68973   -72.12045 1.000 20.44220 ? 121 ILE   B CG2 1 
ATOM   2880 C  CD1 . ILE   B 1 121 ? -34.81940 6.85530   -74.13235 1.000 17.39046 ? 121 ILE   B CD1 1 
ATOM   2881 N  N   . MET   B 1 122 ? -38.39113 5.76789   -69.64846 1.000 28.09291 ? 122 MET   B N   1 
ATOM   2882 C  CA  . MET   B 1 122 ? -38.85604 5.03240   -68.46852 1.000 26.19009 ? 122 MET   B CA  1 
ATOM   2883 C  C   . MET   B 1 122 ? -40.35648 4.76297   -68.54020 1.000 28.50146 ? 122 MET   B C   1 
ATOM   2884 O  O   . MET   B 1 122 ? -40.81100 3.65413   -68.23373 1.000 26.31033 ? 122 MET   B O   1 
ATOM   2885 C  CB  . MET   B 1 122 ? -38.51869 5.80555   -67.19148 1.000 21.70772 ? 122 MET   B CB  1 
ATOM   2886 C  CG  . MET   B 1 122 ? -37.05957 5.65929   -66.71606 1.000 23.15869 ? 122 MET   B CG  1 
ATOM   2887 S  SD  . MET   B 1 122 ? -36.72513 4.09317   -65.88648 1.000 25.25722 ? 122 MET   B SD  1 
ATOM   2888 C  CE  . MET   B 1 122 ? -37.52361 4.36525   -64.30133 1.000 20.14103 ? 122 MET   B CE  1 
ATOM   2889 N  N   . HIS   B 1 123 ? -41.13770 5.76793   -68.93928 1.000 28.02908 ? 123 HIS   B N   1 
ATOM   2890 C  CA  . HIS   B 1 123 ? -42.58118 5.59012   -69.06780 1.000 29.90205 ? 123 HIS   B CA  1 
ATOM   2891 C  C   . HIS   B 1 123 ? -42.91244 4.49981   -70.08168 1.000 30.04157 ? 123 HIS   B C   1 
ATOM   2892 O  O   . HIS   B 1 123 ? -43.74453 3.62454   -69.81959 1.000 34.99683 ? 123 HIS   B O   1 
ATOM   2893 C  CB  . HIS   B 1 123 ? -43.23232 6.91684   -69.46170 1.000 34.23168 ? 123 HIS   B CB  1 
ATOM   2894 C  CG  . HIS   B 1 123 ? -44.72996 6.89512   -69.41144 1.000 43.19273 ? 123 HIS   B CG  1 
ATOM   2895 N  ND1 . HIS   B 1 123 ? -45.50602 7.93398   -69.87913 1.000 45.22695 ? 123 HIS   B ND1 1 
ATOM   2896 C  CD2 . HIS   B 1 123 ? -45.59320 5.95900   -68.95031 1.000 43.96844 ? 123 HIS   B CD2 1 
ATOM   2897 C  CE1 . HIS   B 1 123 ? -46.78253 7.64015   -69.70633 1.000 47.27082 ? 123 HIS   B CE1 1 
ATOM   2898 N  NE2 . HIS   B 1 123 ? -46.86274 6.44666   -69.14585 1.000 45.48400 ? 123 HIS   B NE2 1 
ATOM   2899 N  N   . THR   B 1 124 ? -42.24766 4.52635   -71.23692 1.000 30.52040 ? 124 THR   B N   1 
ATOM   2900 C  CA  . THR   B 1 124 ? -42.43786 3.49254   -72.24724 1.000 27.44982 ? 124 THR   B CA  1 
ATOM   2901 C  C   . THR   B 1 124 ? -42.06128 2.11556   -71.71299 1.000 30.92891 ? 124 THR   B C   1 
ATOM   2902 O  O   . THR   B 1 124 ? -42.79422 1.14039   -71.91140 1.000 33.33645 ? 124 THR   B O   1 
ATOM   2903 C  CB  . THR   B 1 124 ? -41.60665 3.82959   -73.48973 1.000 28.16948 ? 124 THR   B CB  1 
ATOM   2904 O  OG1 . THR   B 1 124 ? -41.95209 5.13761   -73.95705 1.000 32.28013 ? 124 THR   B OG1 1 
ATOM   2905 C  CG2 . THR   B 1 124 ? -41.84193 2.82341   -74.60581 1.000 26.76755 ? 124 THR   B CG2 1 
ATOM   2906 N  N   . ILE   B 1 125 ? -40.90931 2.00760   -71.04457 1.000 29.16049 ? 125 ILE   B N   1 
ATOM   2907 C  CA  . ILE   B 1 125 ? -40.45334 0.70026   -70.57412 1.000 27.90430 ? 125 ILE   B CA  1 
ATOM   2908 C  C   . ILE   B 1 125 ? -41.37696 0.16685   -69.48398 1.000 30.17448 ? 125 ILE   B C   1 
ATOM   2909 O  O   . ILE   B 1 125 ? -41.62561 -1.04076  -69.39690 1.000 32.85115 ? 125 ILE   B O   1 
ATOM   2910 C  CB  . ILE   B 1 125 ? -38.99125 0.77555   -70.09522 1.000 29.76686 ? 125 ILE   B CB  1 
ATOM   2911 C  CG1 . ILE   B 1 125 ? -38.04069 0.79754   -71.29018 1.000 26.74293 ? 125 ILE   B CG1 1 
ATOM   2912 C  CG2 . ILE   B 1 125 ? -38.65594 -0.41401  -69.23512 1.000 24.29938 ? 125 ILE   B CG2 1 
ATOM   2913 C  CD1 . ILE   B 1 125 ? -36.60612 1.09712   -70.93774 1.000 26.99564 ? 125 ILE   B CD1 1 
ATOM   2914 N  N   . PHE   B 1 126 ? -41.88969 1.05276   -68.63056 1.000 28.16460 ? 126 PHE   B N   1 
ATOM   2915 C  CA  . PHE   B 1 126 ? -42.85028 0.63057   -67.61843 1.000 34.85509 ? 126 PHE   B CA  1 
ATOM   2916 C  C   . PHE   B 1 126 ? -44.12979 0.11326   -68.26783 1.000 36.68250 ? 126 PHE   B C   1 
ATOM   2917 O  O   . PHE   B 1 126 ? -44.57497 -1.00184  -67.97530 1.000 35.87560 ? 126 PHE   B O   1 
ATOM   2918 C  CB  . PHE   B 1 126 ? -43.14727 1.78637   -66.66209 1.000 30.19680 ? 126 PHE   B CB  1 
ATOM   2919 C  CG  . PHE   B 1 126 ? -42.21187 1.85247   -65.47604 1.000 36.01927 ? 126 PHE   B CG  1 
ATOM   2920 C  CD1 . PHE   B 1 126 ? -40.82873 1.81173   -65.65094 1.000 30.90687 ? 126 PHE   B CD1 1 
ATOM   2921 C  CD2 . PHE   B 1 126 ? -42.71607 1.96838   -64.18604 1.000 33.84149 ? 126 PHE   B CD2 1 
ATOM   2922 C  CE1 . PHE   B 1 126 ? -39.97376 1.87627   -64.55914 1.000 33.65820 ? 126 PHE   B CE1 1 
ATOM   2923 C  CE2 . PHE   B 1 126 ? -41.86526 2.02822   -63.09328 1.000 32.87635 ? 126 PHE   B CE2 1 
ATOM   2924 C  CZ  . PHE   B 1 126 ? -40.49820 1.98010   -63.27760 1.000 26.18794 ? 126 PHE   B CZ  1 
ATOM   2925 N  N   . GLN   B 1 127 ? -44.72152 0.90957   -69.17106 1.000 37.20713 ? 127 GLN   B N   1 
ATOM   2926 C  CA  . GLN   B 1 127 ? -45.90077 0.46728   -69.91660 1.000 40.01972 ? 127 GLN   B CA  1 
ATOM   2927 C  C   . GLN   B 1 127 ? -45.63074 -0.83092  -70.67201 1.000 39.27533 ? 127 GLN   B C   1 
ATOM   2928 O  O   . GLN   B 1 127 ? -46.42875 -1.77271  -70.60497 1.000 43.71415 ? 127 GLN   B O   1 
ATOM   2929 C  CB  . GLN   B 1 127 ? -46.36321 1.56606   -70.87967 1.000 37.72123 ? 127 GLN   B CB  1 
ATOM   2930 C  CG  . GLN   B 1 127 ? -46.95451 2.80665   -70.19701 1.000 38.75212 ? 127 GLN   B CG  1 
ATOM   2931 C  CD  . GLN   B 1 127 ? -48.35644 2.57546   -69.59435 1.000 44.37426 ? 127 GLN   B CD  1 
ATOM   2932 O  OE1 . GLN   B 1 127 ? -48.90257 1.47341   -69.65386 1.000 46.65745 ? 127 GLN   B OE1 1 
ATOM   2933 N  NE2 . GLN   B 1 127 ? -48.93428 3.62592   -69.01591 1.000 41.73200 ? 127 GLN   B NE2 1 
ATOM   2934 N  N   . GLU   B 1 128 ? -44.49593 -0.90918  -71.36737 1.000 34.48233 ? 128 GLU   B N   1 
ATOM   2935 C  CA  . GLU   B 1 128 ? -44.12555 -2.12451  -72.08593 1.000 34.99646 ? 128 GLU   B CA  1 
ATOM   2936 C  C   . GLU   B 1 128 ? -44.06758 -3.33647  -71.16202 1.000 40.98511 ? 128 GLU   B C   1 
ATOM   2937 O  O   . GLU   B 1 128 ? -44.47742 -4.43729  -71.54784 1.000 38.48478 ? 128 GLU   B O   1 
ATOM   2938 C  CB  . GLU   B 1 128 ? -42.77630 -1.91770  -72.77663 1.000 35.10376 ? 128 GLU   B CB  1 
ATOM   2939 C  CG  . GLU   B 1 128 ? -42.15204 -3.17141  -73.35756 1.000 36.24242 ? 128 GLU   B CG  1 
ATOM   2940 C  CD  . GLU   B 1 128 ? -42.61776 -3.44594  -74.77683 1.000 48.71289 ? 128 GLU   B CD  1 
ATOM   2941 O  OE1 . GLU   B 1 128 ? -42.30424 -4.53994  -75.29225 1.000 47.01306 ? 128 GLU   B OE1 1 
ATOM   2942 O  OE2 . GLU   B 1 128 ? -43.28894 -2.56970  -75.37562 1.000 44.90457 ? 128 GLU   B OE2 1 
ATOM   2943 N  N   . ARG   B 1 129 ? -43.55039 -3.16353  -69.94625 1.000 38.43055 ? 129 ARG   B N   1 
ATOM   2944 C  CA  . ARG   B 1 129 ? -43.38006 -4.27289  -69.01491 1.000 37.72387 ? 129 ARG   B CA  1 
ATOM   2945 C  C   . ARG   B 1 129 ? -44.56245 -4.44720  -68.07380 1.000 38.63301 ? 129 ARG   B C   1 
ATOM   2946 O  O   . ARG   B 1 129 ? -44.50961 -5.31520  -67.19450 1.000 39.15682 ? 129 ARG   B O   1 
ATOM   2947 C  CB  . ARG   B 1 129 ? -42.09588 -4.09533  -68.18984 1.000 34.95525 ? 129 ARG   B CB  1 
ATOM   2948 C  CG  . ARG   B 1 129 ? -40.81671 -4.41456  -68.94751 1.000 36.58256 ? 129 ARG   B CG  1 
ATOM   2949 C  CD  . ARG   B 1 129 ? -39.61278 -4.49612  -68.01285 1.000 37.87010 ? 129 ARG   B CD  1 
ATOM   2950 N  NE  . ARG   B 1 129 ? -38.40689 -4.86684  -68.74251 1.000 26.88902 ? 129 ARG   B NE  1 
ATOM   2951 C  CZ  . ARG   B 1 129 ? -37.99681 -6.11526  -68.90572 1.000 29.91177 ? 129 ARG   B CZ  1 
ATOM   2952 N  NH1 . ARG   B 1 129 ? -38.69698 -7.11242  -68.38150 1.000 38.00026 ? 129 ARG   B NH1 1 
ATOM   2953 N  NH2 . ARG   B 1 129 ? -36.89596 -6.37195  -69.60097 1.000 28.40081 ? 129 ARG   B NH2 1 
ATOM   2954 N  N   . ASP   B 1 130 ? -45.60913 -3.63548  -68.22102 1.000 38.46835 ? 130 ASP   B N   1 
ATOM   2955 C  CA  . ASP   B 1 130 ? -46.83687 -3.75501  -67.43805 1.000 46.51129 ? 130 ASP   B CA  1 
ATOM   2956 C  C   . ASP   B 1 130 ? -46.61896 -3.44996  -65.95587 1.000 42.28919 ? 130 ASP   B C   1 
ATOM   2957 O  O   . ASP   B 1 130 ? -47.39121 -3.90773  -65.10597 1.000 39.73618 ? 130 ASP   B O   1 
ATOM   2958 C  CB  . ASP   B 1 130 ? -47.45028 -5.15367  -67.61637 1.000 46.65616 ? 130 ASP   B CB  1 
ATOM   2959 C  CG  . ASP   B 1 130 ? -48.95619 -5.15274  -67.50767 1.000 48.16745 ? 130 ASP   B CG  1 
ATOM   2960 O  OD1 . ASP   B 1 130 ? -49.54595 -4.05777  -67.35171 1.000 45.92625 ? 130 ASP   B OD1 1 
ATOM   2961 O  OD2 . ASP   B 1 130 ? -49.54457 -6.25665  -67.58537 1.000 52.30676 ? 130 ASP   B OD2 1 
ATOM   2962 N  N   . LEU   B 1 131 ? -45.58001 -2.67074  -65.63113 1.000 37.78098 ? 131 LEU   B N   1 
ATOM   2963 C  CA  . LEU   B 1 131 ? -45.19298 -2.43813  -64.24465 1.000 35.03263 ? 131 LEU   B CA  1 
ATOM   2964 C  C   . LEU   B 1 131 ? -46.15323 -1.51189  -63.51163 1.000 34.19011 ? 131 LEU   B C   1 
ATOM   2965 O  O   . LEU   B 1 131 ? -46.23207 -1.57992  -62.28126 1.000 36.72826 ? 131 LEU   B O   1 
ATOM   2966 C  CB  . LEU   B 1 131 ? -43.77840 -1.85262  -64.17534 1.000 34.35036 ? 131 LEU   B CB  1 
ATOM   2967 C  CG  . LEU   B 1 131 ? -42.62337 -2.68284  -64.73356 1.000 36.54906 ? 131 LEU   B CG  1 
ATOM   2968 C  CD1 . LEU   B 1 131 ? -41.33238 -1.85914  -64.79602 1.000 32.86299 ? 131 LEU   B CD1 1 
ATOM   2969 C  CD2 . LEU   B 1 131 ? -42.40783 -3.93073  -63.90026 1.000 33.58021 ? 131 LEU   B CD2 1 
ATOM   2970 N  N   . LEU   B 1 132 ? -46.86401 -0.63180  -64.21895 1.000 31.44333 ? 132 LEU   B N   1 
ATOM   2971 C  CA  . LEU   B 1 132 ? -47.82018 0.22670   -63.52797 1.000 35.34267 ? 132 LEU   B CA  1 
ATOM   2972 C  C   . LEU   B 1 132 ? -48.95179 -0.58780  -62.91866 1.000 40.20258 ? 132 LEU   B C   1 
ATOM   2973 O  O   . LEU   B 1 132 ? -49.39394 -0.29988  -61.80253 1.000 39.19191 ? 132 LEU   B O   1 
ATOM   2974 C  CB  . LEU   B 1 132 ? -48.37940 1.28475   -64.47139 1.000 36.78057 ? 132 LEU   B CB  1 
ATOM   2975 C  CG  . LEU   B 1 132 ? -47.34490 2.30809   -64.92069 1.000 39.55394 ? 132 LEU   B CG  1 
ATOM   2976 C  CD1 . LEU   B 1 132 ? -46.77179 1.90160   -66.27484 1.000 38.48887 ? 132 LEU   B CD1 1 
ATOM   2977 C  CD2 . LEU   B 1 132 ? -47.95331 3.70517   -64.96355 1.000 38.53259 ? 132 LEU   B CD2 1 
ATOM   2978 N  N   . LYS   B 1 133 ? -49.43027 -1.61266  -63.62657 1.000 40.19366 ? 133 LYS   B N   1 
ATOM   2979 C  CA  . LYS   B 1 133 ? -50.52912 -2.40981  -63.08975 1.000 42.81751 ? 133 LYS   B CA  1 
ATOM   2980 C  C   . LYS   B 1 133 ? -50.02534 -3.36928  -62.02498 1.000 39.66195 ? 133 LYS   B C   1 
ATOM   2981 O  O   . LYS   B 1 133 ? -50.60115 -3.46104  -60.93665 1.000 47.90635 ? 133 LYS   B O   1 
ATOM   2982 C  CB  . LYS   B 1 133 ? -51.23719 -3.17181  -64.21228 1.000 45.43190 ? 133 LYS   B CB  1 
ATOM   2983 C  CG  . LYS   B 1 133 ? -51.68298 -2.29460  -65.36889 1.000 51.86514 ? 133 LYS   B CG  1 
ATOM   2984 C  CD  . LYS   B 1 133 ? -53.12311 -2.57854  -65.77827 1.000 61.59506 ? 133 LYS   B CD  1 
ATOM   2985 C  CE  . LYS   B 1 133 ? -53.62789 -1.53530  -66.76791 1.000 64.18435 ? 133 LYS   B CE  1 
ATOM   2986 N  NZ  . LYS   B 1 133 ? -55.10742 -1.59910  -66.93119 1.000 67.26651 ? 133 LYS   B NZ  1 
ATOM   2987 N  N   . THR   B 1 134 ? -48.94445 -4.08773  -62.32817 1.000 37.34051 ? 134 THR   B N   1 
ATOM   2988 C  CA  . THR   B 1 134 ? -48.35946 -5.02949  -61.38325 1.000 40.53423 ? 134 THR   B CA  1 
ATOM   2989 C  C   . THR   B 1 134 ? -48.14542 -4.39909  -60.01268 1.000 40.35207 ? 134 THR   B C   1 
ATOM   2990 O  O   . THR   B 1 134 ? -48.45429 -5.00660  -58.98146 1.000 41.45456 ? 134 THR   B O   1 
ATOM   2991 C  CB  . THR   B 1 134 ? -47.03414 -5.54403  -61.93762 1.000 35.97781 ? 134 THR   B CB  1 
ATOM   2992 O  OG1 . THR   B 1 134 ? -47.23906 -6.04597  -63.26420 1.000 36.20459 ? 134 THR   B OG1 1 
ATOM   2993 C  CG2 . THR   B 1 134 ? -46.47137 -6.64236  -61.04057 1.000 40.65467 ? 134 THR   B CG2 1 
ATOM   2994 N  N   . PHE   B 1 135 ? -47.62406 -3.17123  -59.98365 1.000 37.16050 ? 135 PHE   B N   1 
ATOM   2995 C  CA  . PHE   B 1 135 ? -47.23314 -2.51889  -58.74103 1.000 35.91601 ? 135 PHE   B CA  1 
ATOM   2996 C  C   . PHE   B 1 135 ? -48.12628 -1.33469  -58.40524 1.000 38.72986 ? 135 PHE   B C   1 
ATOM   2997 O  O   . PHE   B 1 135 ? -47.77329 -0.52777  -57.53879 1.000 32.39827 ? 135 PHE   B O   1 
ATOM   2998 C  CB  . PHE   B 1 135 ? -45.76199 -2.09429  -58.80400 1.000 33.17005 ? 135 PHE   B CB  1 
ATOM   2999 C  CG  . PHE   B 1 135 ? -44.80957 -3.25172  -58.86217 1.000 28.59169 ? 135 PHE   B CG  1 
ATOM   3000 C  CD1 . PHE   B 1 135 ? -44.59578 -4.03686  -57.74551 1.000 29.06985 ? 135 PHE   B CD1 1 
ATOM   3001 C  CD2 . PHE   B 1 135 ? -44.14393 -3.56583  -60.03557 1.000 31.49991 ? 135 PHE   B CD2 1 
ATOM   3002 C  CE1 . PHE   B 1 135 ? -43.74080 -5.10939  -57.79426 1.000 28.60819 ? 135 PHE   B CE1 1 
ATOM   3003 C  CE2 . PHE   B 1 135 ? -43.27616 -4.63588  -60.09430 1.000 29.54945 ? 135 PHE   B CE2 1 
ATOM   3004 C  CZ  . PHE   B 1 135 ? -43.07541 -5.41353  -58.97384 1.000 37.09244 ? 135 PHE   B CZ  1 
ATOM   3005 N  N   . LYS   B 1 136 ? -49.28068 -1.23092  -59.06880 1.000 40.61631 ? 136 LYS   B N   1 
ATOM   3006 C  CA  . LYS   B 1 136 ? -50.27926 -0.18655  -58.82078 1.000 36.91443 ? 136 LYS   B CA  1 
ATOM   3007 C  C   . LYS   B 1 136 ? -49.63999 1.19159   -58.67431 1.000 40.93134 ? 136 LYS   B C   1 
ATOM   3008 O  O   . LYS   B 1 136 ? -49.85634 1.91399   -57.69716 1.000 40.50019 ? 136 LYS   B O   1 
ATOM   3009 C  CB  . LYS   B 1 136 ? -51.13776 -0.52153  -57.60098 1.000 46.89059 ? 136 LYS   B CB  1 
ATOM   3010 C  CG  . LYS   B 1 136 ? -52.26595 -1.51267  -57.89196 1.000 50.78699 ? 136 LYS   B CG  1 
ATOM   3011 C  CD  . LYS   B 1 136 ? -51.76715 -2.95112  -57.82762 1.000 49.20419 ? 136 LYS   B CD  1 
ATOM   3012 C  CE  . LYS   B 1 136 ? -52.63903 -3.77978  -56.88307 1.000 54.27222 ? 136 LYS   B CE  1 
ATOM   3013 N  NZ  . LYS   B 1 136 ? -52.18993 -5.20442  -56.80774 1.000 58.32938 ? 136 LYS   B NZ  1 
ATOM   3014 N  N   . ILE   B 1 137 ? -48.84748 1.56103   -59.67299 1.000 40.62340 ? 137 ILE   B N   1 
ATOM   3015 C  CA  . ILE   B 1 137 ? -48.23343 2.88275   -59.73719 1.000 36.71650 ? 137 ILE   B CA  1 
ATOM   3016 C  C   . ILE   B 1 137 ? -49.17440 3.80399   -60.50903 1.000 34.05593 ? 137 ILE   B C   1 
ATOM   3017 O  O   . ILE   B 1 137 ? -49.39982 3.57162   -61.70695 1.000 39.88713 ? 137 ILE   B O   1 
ATOM   3018 C  CB  . ILE   B 1 137 ? -46.85512 2.83291   -60.40878 1.000 37.00646 ? 137 ILE   B CB  1 
ATOM   3019 C  CG1 . ILE   B 1 137 ? -45.96241 1.76733   -59.75690 1.000 33.66515 ? 137 ILE   B CG1 1 
ATOM   3020 C  CG2 . ILE   B 1 137 ? -46.20309 4.21211   -60.36240 1.000 28.29362 ? 137 ILE   B CG2 1 
ATOM   3021 C  CD1 . ILE   B 1 137 ? -44.75542 1.38087   -60.59527 1.000 30.99914 ? 137 ILE   B CD1 1 
ATOM   3022 N  N   . PRO   B 1 138 ? -49.71884 4.84501   -59.88740 1.000 34.76558 ? 138 PRO   B N   1 
ATOM   3023 C  CA  . PRO   B 1 138 ? -50.51115 5.82365   -60.64415 1.000 37.24561 ? 138 PRO   B CA  1 
ATOM   3024 C  C   . PRO   B 1 138 ? -49.64416 6.50996   -61.69079 1.000 40.07974 ? 138 PRO   B C   1 
ATOM   3025 O  O   . PRO   B 1 138 ? -48.51946 6.93039   -61.40202 1.000 36.21379 ? 138 PRO   B O   1 
ATOM   3026 C  CB  . PRO   B 1 138 ? -50.98408 6.80829   -59.56773 1.000 35.69130 ? 138 PRO   B CB  1 
ATOM   3027 C  CG  . PRO   B 1 138 ? -50.72679 6.13448   -58.26231 1.000 35.43258 ? 138 PRO   B CG  1 
ATOM   3028 C  CD  . PRO   B 1 138 ? -49.56384 5.22780   -58.47845 1.000 34.63718 ? 138 PRO   B CD  1 
ATOM   3029 N  N   . VAL   B 1 139 ? -50.17470 6.62356   -62.91604 1.000 35.29483 ? 139 VAL   B N   1 
ATOM   3030 C  CA  . VAL   B 1 139 ? -49.35260 7.10590   -64.02620 1.000 33.42976 ? 139 VAL   B CA  1 
ATOM   3031 C  C   . VAL   B 1 139 ? -48.88056 8.52958   -63.76570 1.000 32.34574 ? 139 VAL   B C   1 
ATOM   3032 O  O   . VAL   B 1 139 ? -47.73304 8.87827   -64.06704 1.000 39.02537 ? 139 VAL   B O   1 
ATOM   3033 C  CB  . VAL   B 1 139 ? -50.10353 6.99033   -65.36855 1.000 40.43227 ? 139 VAL   B CB  1 
ATOM   3034 C  CG1 . VAL   B 1 139 ? -51.21682 8.03314   -65.47791 1.000 33.01357 ? 139 VAL   B CG1 1 
ATOM   3035 C  CG2 . VAL   B 1 139 ? -49.11534 7.12511   -66.53619 1.000 33.60775 ? 139 VAL   B CG2 1 
ATOM   3036 N  N   . ASP   B 1 140 ? -49.73912 9.36455   -63.17428 1.000 29.62359 ? 140 ASP   B N   1 
ATOM   3037 C  CA  . ASP   B 1 140 ? -49.33862 10.72989  -62.85028 1.000 33.33541 ? 140 ASP   B CA  1 
ATOM   3038 C  C   . ASP   B 1 140 ? -48.23898 10.75807  -61.79652 1.000 35.03243 ? 140 ASP   B C   1 
ATOM   3039 O  O   . ASP   B 1 140 ? -47.40895 11.67672  -61.79421 1.000 29.58192 ? 140 ASP   B O   1 
ATOM   3040 C  CB  . ASP   B 1 140 ? -50.54448 11.53003  -62.36493 1.000 35.75166 ? 140 ASP   B CB  1 
ATOM   3041 C  CG  . ASP   B 1 140 ? -51.29159 10.83025  -61.23462 1.000 42.53761 ? 140 ASP   B CG  1 
ATOM   3042 O  OD1 . ASP   B 1 140 ? -51.62907 9.63083   -61.40655 1.000 41.02977 ? 140 ASP   B OD1 1 
ATOM   3043 O  OD2 . ASP   B 1 140 ? -51.53759 11.47373  -60.17938 1.000 42.84550 ? 140 ASP   B OD2 1 
ATOM   3044 N  N   . THR   B 1 141 ? -48.23292 9.77833   -60.88418 1.000 33.54080 ? 141 THR   B N   1 
ATOM   3045 C  CA  . THR   B 1 141 ? -47.16437 9.68726   -59.89246 1.000 32.58652 ? 141 THR   B CA  1 
ATOM   3046 C  C   . THR   B 1 141 ? -45.86510 9.22815   -60.54446 1.000 32.27547 ? 141 THR   B C   1 
ATOM   3047 O  O   . THR   B 1 141 ? -44.78715 9.75612   -60.23926 1.000 30.21127 ? 141 THR   B O   1 
ATOM   3048 C  CB  . THR   B 1 141 ? -47.57020 8.73591   -58.75741 1.000 35.46071 ? 141 THR   B CB  1 
ATOM   3049 O  OG1 . THR   B 1 141 ? -48.81526 9.16049   -58.17526 1.000 26.52415 ? 141 THR   B OG1 1 
ATOM   3050 C  CG2 . THR   B 1 141 ? -46.48427 8.69929   -57.66852 1.000 27.66374 ? 141 THR   B CG2 1 
ATOM   3051 N  N   . LEU   B 1 142 ? -45.95005 8.25386   -61.45367 1.000 26.44427 ? 142 LEU   B N   1 
ATOM   3052 C  CA  . LEU   B 1 142 ? -44.77861 7.85974   -62.22272 1.000 31.19940 ? 142 LEU   B CA  1 
ATOM   3053 C  C   . LEU   B 1 142 ? -44.20636 9.04428   -62.99588 1.000 33.91078 ? 142 LEU   B C   1 
ATOM   3054 O  O   . LEU   B 1 142 ? -42.98942 9.28256   -62.97901 1.000 29.06253 ? 142 LEU   B O   1 
ATOM   3055 C  CB  . LEU   B 1 142 ? -45.12825 6.71297   -63.17395 1.000 32.49894 ? 142 LEU   B CB  1 
ATOM   3056 C  CG  . LEU   B 1 142 ? -43.95765 6.19733   -64.01958 1.000 28.31811 ? 142 LEU   B CG  1 
ATOM   3057 C  CD1 . LEU   B 1 142 ? -42.84444 5.64637   -63.13059 1.000 30.56400 ? 142 LEU   B CD1 1 
ATOM   3058 C  CD2 . LEU   B 1 142 ? -44.40763 5.13947   -64.99505 1.000 33.08163 ? 142 LEU   B CD2 1 
ATOM   3059 N  N   . ILE   B 1 143 ? -45.07174 9.80519   -63.67380 1.000 29.86543 ? 143 ILE   B N   1 
ATOM   3060 C  CA  . ILE   B 1 143 ? -44.59644 10.90539  -64.50970 1.000 28.69102 ? 143 ILE   B CA  1 
ATOM   3061 C  C   . ILE   B 1 143 ? -44.02024 12.00529  -63.64250 1.000 29.92838 ? 143 ILE   B C   1 
ATOM   3062 O  O   . ILE   B 1 143 ? -42.96877 12.57000  -63.94858 1.000 26.62481 ? 143 ILE   B O   1 
ATOM   3063 C  CB  . ILE   B 1 143 ? -45.72417 11.44964  -65.40759 1.000 31.18887 ? 143 ILE   B CB  1 
ATOM   3064 C  CG1 . ILE   B 1 143 ? -46.23691 10.37454  -66.36322 1.000 31.82374 ? 143 ILE   B CG1 1 
ATOM   3065 C  CG2 . ILE   B 1 143 ? -45.24902 12.67807  -66.17077 1.000 26.49585 ? 143 ILE   B CG2 1 
ATOM   3066 C  CD1 . ILE   B 1 143 ? -45.15881 9.49511   -66.94289 1.000 33.30202 ? 143 ILE   B CD1 1 
ATOM   3067 N  N   . THR   B 1 144 ? -44.71065 12.33268  -62.54884 1.000 29.09627 ? 144 THR   B N   1 
ATOM   3068 C  CA  . THR   B 1 144 ? -44.21093 13.35867  -61.64418 1.000 28.24897 ? 144 THR   B CA  1 
ATOM   3069 C  C   . THR   B 1 144 ? -42.82311 13.00012  -61.11462 1.000 28.02411 ? 144 THR   B C   1 
ATOM   3070 O  O   . THR   B 1 144 ? -41.91754 13.84213  -61.09186 1.000 25.37605 ? 144 THR   B O   1 
ATOM   3071 C  CB  . THR   B 1 144 ? -45.20318 13.56092  -60.49753 1.000 32.13730 ? 144 THR   B CB  1 
ATOM   3072 O  OG1 . THR   B 1 144 ? -46.50687 13.82433  -61.03562 1.000 28.06766 ? 144 THR   B OG1 1 
ATOM   3073 C  CG2 . THR   B 1 144 ? -44.77600 14.72007  -59.62762 1.000 26.58083 ? 144 THR   B CG2 1 
ATOM   3074 N  N   . TYR   B 1 145 ? -42.63490 11.75144  -60.68140 1.000 28.15134 ? 145 TYR   B N   1 
ATOM   3075 C  CA  . TYR   B 1 145 ? -41.33366 11.36023  -60.14480 1.000 24.67619 ? 145 TYR   B CA  1 
ATOM   3076 C  C   . TYR   B 1 145 ? -40.26365 11.41880  -61.22883 1.000 27.14653 ? 145 TYR   B C   1 
ATOM   3077 O  O   . TYR   B 1 145 ? -39.18395 11.98690  -61.02194 1.000 25.09574 ? 145 TYR   B O   1 
ATOM   3078 C  CB  . TYR   B 1 145 ? -41.38844 9.95962   -59.51518 1.000 22.64762 ? 145 TYR   B CB  1 
ATOM   3079 C  CG  . TYR   B 1 145 ? -40.00308 9.49905   -59.09142 1.000 20.50378 ? 145 TYR   B CG  1 
ATOM   3080 C  CD1 . TYR   B 1 145 ? -39.40620 9.98280   -57.93073 1.000 18.18175 ? 145 TYR   B CD1 1 
ATOM   3081 C  CD2 . TYR   B 1 145 ? -39.27192 8.61786   -59.88287 1.000 19.52086 ? 145 TYR   B CD2 1 
ATOM   3082 C  CE1 . TYR   B 1 145 ? -38.10615 9.58266   -57.56747 1.000 20.44119 ? 145 TYR   B CE1 1 
ATOM   3083 C  CE2 . TYR   B 1 145 ? -37.98518 8.22156   -59.53367 1.000 18.26346 ? 145 TYR   B CE2 1 
ATOM   3084 C  CZ  . TYR   B 1 145 ? -37.40883 8.69580   -58.38155 1.000 18.83103 ? 145 TYR   B CZ  1 
ATOM   3085 O  OH  . TYR   B 1 145 ? -36.13171 8.27411   -58.06879 1.000 18.90347 ? 145 TYR   B OH  1 
ATOM   3086 N  N   . LEU   B 1 146 ? -40.55811 10.84566  -62.40065 1.000 24.92386 ? 146 LEU   B N   1 
ATOM   3087 C  CA  . LEU   B 1 146 ? -39.58310 10.80502  -63.48492 1.000 26.18417 ? 146 LEU   B CA  1 
ATOM   3088 C  C   . LEU   B 1 146 ? -39.12416 12.19949  -63.89044 1.000 29.21559 ? 146 LEU   B C   1 
ATOM   3089 O  O   . LEU   B 1 146 ? -37.94902 12.39601  -64.22097 1.000 26.02245 ? 146 LEU   B O   1 
ATOM   3090 C  CB  . LEU   B 1 146 ? -40.17184 10.07255  -64.68304 1.000 23.25094 ? 146 LEU   B CB  1 
ATOM   3091 C  CG  . LEU   B 1 146 ? -40.26262 8.56781   -64.48297 1.000 20.99639 ? 146 LEU   B CG  1 
ATOM   3092 C  CD1 . LEU   B 1 146 ? -41.03631 7.95898   -65.63380 1.000 22.19094 ? 146 LEU   B CD1 1 
ATOM   3093 C  CD2 . LEU   B 1 146 ? -38.87833 7.96036   -64.37601 1.000 23.21630 ? 146 LEU   B CD2 1 
ATOM   3094 N  N   . MET   B 1 147 ? -40.03327 13.18005  -63.88809 1.000 24.89871 ? 147 MET   B N   1 
ATOM   3095 C  CA  . MET   B 1 147 ? -39.63732 14.53126  -64.27657 1.000 26.84556 ? 147 MET   B CA  1 
ATOM   3096 C  C   . MET   B 1 147 ? -38.79277 15.19597  -63.20194 1.000 25.98031 ? 147 MET   B C   1 
ATOM   3097 O  O   . MET   B 1 147 ? -37.84855 15.93026  -63.51848 1.000 25.81391 ? 147 MET   B O   1 
ATOM   3098 C  CB  . MET   B 1 147 ? -40.86623 15.38189  -64.57579 1.000 29.12205 ? 147 MET   B CB  1 
ATOM   3099 C  CG  . MET   B 1 147 ? -41.76588 14.75949  -65.60711 1.000 31.12953 ? 147 MET   B CG  1 
ATOM   3100 S  SD  . MET   B 1 147 ? -42.92713 15.96881  -66.24786 1.000 60.31429 ? 147 MET   B SD  1 
ATOM   3101 C  CE  . MET   B 1 147 ? -43.98642 16.20202  -64.81114 1.000 43.95246 ? 147 MET   B CE  1 
ATOM   3102 N  N   . THR   B 1 148 ? -39.12545 14.97648  -61.92657 1.000 23.74533 ? 148 THR   B N   1 
ATOM   3103 C  CA  . THR   B 1 148 ? -38.27255 15.50804  -60.86356 1.000 22.98333 ? 148 THR   B CA  1 
ATOM   3104 C  C   . THR   B 1 148 ? -36.89661 14.85861  -60.89145 1.000 20.52289 ? 148 THR   B C   1 
ATOM   3105 O  O   . THR   B 1 148 ? -35.87463 15.54296  -60.73275 1.000 19.85842 ? 148 THR   B O   1 
ATOM   3106 C  CB  . THR   B 1 148 ? -38.90310 15.29521  -59.48842 1.000 25.73621 ? 148 THR   B CB  1 
ATOM   3107 O  OG1 . THR   B 1 148 ? -40.32309 15.47936  -59.56066 1.000 30.51823 ? 148 THR   B OG1 1 
ATOM   3108 C  CG2 . THR   B 1 148 ? -38.29611 16.27709  -58.49915 1.000 19.43773 ? 148 THR   B CG2 1 
ATOM   3109 N  N   . LEU   B 1 149 ? -36.85948 13.53347  -61.06137 1.000 19.67478 ? 149 LEU   B N   1 
ATOM   3110 C  CA  . LEU   B 1 149 ? -35.58547 12.82812  -61.18736 1.000 21.15624 ? 149 LEU   B CA  1 
ATOM   3111 C  C   . LEU   B 1 149 ? -34.75409 13.40394  -62.32716 1.000 22.66464 ? 149 LEU   B C   1 
ATOM   3112 O  O   . LEU   B 1 149 ? -33.59919 13.80321  -62.12919 1.000 20.75408 ? 149 LEU   B O   1 
ATOM   3113 C  CB  . LEU   B 1 149 ? -35.83309 11.33190  -61.40443 1.000 20.72873 ? 149 LEU   B CB  1 
ATOM   3114 C  CG  . LEU   B 1 149 ? -34.57369 10.46778  -61.54371 1.000 19.58942 ? 149 LEU   B CG  1 
ATOM   3115 C  CD1 . LEU   B 1 149 ? -33.81357 10.48996  -60.22758 1.000 17.61996 ? 149 LEU   B CD1 1 
ATOM   3116 C  CD2 . LEU   B 1 149 ? -34.93641 9.05038   -61.93402 1.000 16.53680 ? 149 LEU   B CD2 1 
ATOM   3117 N  N   . GLU   B 1 150 ? -35.33266 13.44916  -63.53394 1.000 23.80495 ? 150 GLU   B N   1 
ATOM   3118 C  CA  . GLU   B 1 150 ? -34.63640 14.00306  -64.69513 1.000 20.51076 ? 150 GLU   B CA  1 
ATOM   3119 C  C   . GLU   B 1 150 ? -34.16173 15.42971  -64.43501 1.000 19.45101 ? 150 GLU   B C   1 
ATOM   3120 O  O   . GLU   B 1 150 ? -33.04927 15.80240  -64.83459 1.000 21.90186 ? 150 GLU   B O   1 
ATOM   3121 C  CB  . GLU   B 1 150 ? -35.55149 13.94174  -65.92296 1.000 23.28493 ? 150 GLU   B CB  1 
ATOM   3122 C  CG  . GLU   B 1 150 ? -34.88986 14.31329  -67.25356 1.000 24.81328 ? 150 GLU   B CG  1 
ATOM   3123 C  CD  . GLU   B 1 150 ? -35.52029 13.58202  -68.43811 1.000 25.33398 ? 150 GLU   B CD  1 
ATOM   3124 O  OE1 . GLU   B 1 150 ? -36.74394 13.33648  -68.39812 1.000 27.06484 ? 150 GLU   B OE1 1 
ATOM   3125 O  OE2 . GLU   B 1 150 ? -34.79383 13.21954  -69.39212 1.000 22.05065 ? 150 GLU   B OE2 1 
ATOM   3126 N  N   . ASP   B 1 151 ? -34.97356 16.23303  -63.73791 1.000 22.12686 ? 151 ASP   B N   1 
ATOM   3127 C  CA  . ASP   B 1 151 ? -34.57308 17.60101  -63.40769 1.000 22.76579 ? 151 ASP   B CA  1 
ATOM   3128 C  C   . ASP   B 1 151 ? -33.32570 17.63897  -62.53395 1.000 22.52812 ? 151 ASP   B C   1 
ATOM   3129 O  O   . ASP   B 1 151 ? -32.64439 18.66643  -62.47355 1.000 21.50425 ? 151 ASP   B O   1 
ATOM   3130 C  CB  . ASP   B 1 151 ? -35.70588 18.33884  -62.68041 1.000 26.07060 ? 151 ASP   B CB  1 
ATOM   3131 C  CG  . ASP   B 1 151 ? -36.86331 18.72480  -63.59253 1.000 27.38636 ? 151 ASP   B CG  1 
ATOM   3132 O  OD1 . ASP   B 1 151 ? -36.69208 18.76762  -64.82807 1.000 23.80881 ? 151 ASP   B OD1 1 
ATOM   3133 O  OD2 . ASP   B 1 151 ? -37.96404 18.97507  -63.04754 1.000 27.63583 ? 151 ASP   B OD2 1 
ATOM   3134 N  N   . HIS   B 1 152 ? -33.02509 16.55777  -61.81584 1.000 20.76470 ? 152 HIS   B N   1 
ATOM   3135 C  CA  . HIS   B 1 152 ? -31.85643 16.57022  -60.94732 1.000 17.61360 ? 152 HIS   B CA  1 
ATOM   3136 C  C   . HIS   B 1 152 ? -30.61821 16.00414  -61.62028 1.000 19.42309 ? 152 HIS   B C   1 
ATOM   3137 O  O   . HIS   B 1 152 ? -29.55680 15.94716  -60.98488 1.000 17.12064 ? 152 HIS   B O   1 
ATOM   3138 C  CB  . HIS   B 1 152 ? -32.14502 15.81943  -59.63862 1.000 18.55508 ? 152 HIS   B CB  1 
ATOM   3139 C  CG  . HIS   B 1 152 ? -32.87575 16.64101  -58.62614 1.000 15.31429 ? 152 HIS   B CG  1 
ATOM   3140 N  ND1 . HIS   B 1 152 ? -34.23686 16.85578  -58.67933 1.000 19.52633 ? 152 HIS   B ND1 1 
ATOM   3141 C  CD2 . HIS   B 1 152 ? -32.43280 17.29630  -57.52704 1.000 17.16330 ? 152 HIS   B CD2 1 
ATOM   3142 C  CE1 . HIS   B 1 152 ? -34.59966 17.61358  -57.65963 1.000 14.98146 ? 152 HIS   B CE1 1 
ATOM   3143 N  NE2 . HIS   B 1 152 ? -33.52128 17.89255  -56.94464 1.000 20.12288 ? 152 HIS   B NE2 1 
ATOM   3144 N  N   . TYR   B 1 153 ? -30.72518 15.59269  -62.88300 1.000 16.31090 ? 153 TYR   B N   1 
ATOM   3145 C  CA  . TYR   B 1 153 ? -29.55806 15.42557  -63.73648 1.000 18.12670 ? 153 TYR   B CA  1 
ATOM   3146 C  C   . TYR   B 1 153 ? -29.17056 16.77996  -64.31578 1.000 22.59182 ? 153 TYR   B C   1 
ATOM   3147 O  O   . TYR   B 1 153 ? -30.03313 17.51993  -64.80539 1.000 18.46596 ? 153 TYR   B O   1 
ATOM   3148 C  CB  . TYR   B 1 153 ? -29.83719 14.42389  -64.85463 1.000 16.62988 ? 153 TYR   B CB  1 
ATOM   3149 C  CG  . TYR   B 1 153 ? -29.72780 12.98891  -64.39833 1.000 18.17413 ? 153 TYR   B CG  1 
ATOM   3150 C  CD1 . TYR   B 1 153 ? -28.50722 12.32937  -64.42124 1.000 17.04617 ? 153 TYR   B CD1 1 
ATOM   3151 C  CD2 . TYR   B 1 153 ? -30.84449 12.28966  -63.94232 1.000 18.34669 ? 153 TYR   B CD2 1 
ATOM   3152 C  CE1 . TYR   B 1 153 ? -28.39276 10.99912  -64.00251 1.000 14.93302 ? 153 TYR   B CE1 1 
ATOM   3153 C  CE2 . TYR   B 1 153 ? -30.74746 10.94709  -63.52282 1.000 13.95632 ? 153 TYR   B CE2 1 
ATOM   3154 C  CZ  . TYR   B 1 153 ? -29.51193 10.31369  -63.54910 1.000 15.08496 ? 153 TYR   B CZ  1 
ATOM   3155 O  OH  . TYR   B 1 153 ? -29.37431 8.99009   -63.14362 1.000 11.54315 ? 153 TYR   B OH  1 
ATOM   3156 N  N   . HIS   B 1 154 ? -27.87412 17.09451  -64.26814 1.000 20.25204 ? 154 HIS   B N   1 
ATOM   3157 C  CA  . HIS   B 1 154 ? -27.39358 18.41031  -64.66548 1.000 20.16593 ? 154 HIS   B CA  1 
ATOM   3158 C  C   . HIS   B 1 154 ? -27.36994 18.54170  -66.18667 1.000 19.66994 ? 154 HIS   B C   1 
ATOM   3159 O  O   . HIS   B 1 154 ? -26.68830 17.77743  -66.87259 1.000 19.32682 ? 154 HIS   B O   1 
ATOM   3160 C  CB  . HIS   B 1 154 ? -25.98759 18.64864  -64.12149 1.000 17.94104 ? 154 HIS   B CB  1 
ATOM   3161 C  CG  . HIS   B 1 154 ? -25.87918 18.60599  -62.62745 1.000 22.14886 ? 154 HIS   B CG  1 
ATOM   3162 N  ND1 . HIS   B 1 154 ? -24.84097 19.20818  -61.94975 1.000 21.39485 ? 154 HIS   B ND1 1 
ATOM   3163 C  CD2 . HIS   B 1 154 ? -26.65632 18.02394  -61.68105 1.000 21.62131 ? 154 HIS   B CD2 1 
ATOM   3164 C  CE1 . HIS   B 1 154 ? -24.98441 19.00649  -60.65122 1.000 17.25564 ? 154 HIS   B CE1 1 
ATOM   3165 N  NE2 . HIS   B 1 154 ? -26.08262 18.29761  -60.46054 1.000 21.47868 ? 154 HIS   B NE2 1 
ATOM   3166 N  N   . ALA   B 1 155 ? -28.05075 19.55906  -66.70877 1.000 26.16115 ? 155 ALA   B N   1 
ATOM   3167 C  CA  . ALA   B 1 155 ? -28.06049 19.78563  -68.14952 1.000 25.24959 ? 155 ALA   B CA  1 
ATOM   3168 C  C   . ALA   B 1 155 ? -26.73823 20.32753  -68.69204 1.000 21.46037 ? 155 ALA   B C   1 
ATOM   3169 O  O   . ALA   B 1 155 ? -26.49010 20.19835  -69.89210 1.000 28.63916 ? 155 ALA   B O   1 
ATOM   3170 C  CB  . ALA   B 1 155 ? -29.19841 20.73980  -68.52715 1.000 28.78576 ? 155 ALA   B CB  1 
ATOM   3171 N  N   . ASP   B 1 156 ? -25.87620 20.90465  -67.85294 1.000 22.16711 ? 156 ASP   B N   1 
ATOM   3172 C  CA  . ASP   B 1 156 ? -24.59313 21.44759  -68.30231 1.000 22.95271 ? 156 ASP   B CA  1 
ATOM   3173 C  C   . ASP   B 1 156 ? -23.42674 20.47181  -68.10072 1.000 21.86118 ? 156 ASP   B C   1 
ATOM   3174 O  O   . ASP   B 1 156 ? -22.26054 20.87534  -68.17225 1.000 22.56133 ? 156 ASP   B O   1 
ATOM   3175 C  CB  . ASP   B 1 156 ? -24.30827 22.77614  -67.59960 1.000 18.84203 ? 156 ASP   B CB  1 
ATOM   3176 C  CG  . ASP   B 1 156 ? -24.15192 22.62413  -66.10271 1.000 25.78244 ? 156 ASP   B CG  1 
ATOM   3177 O  OD1 . ASP   B 1 156 ? -24.61336 21.59995  -65.54021 1.000 24.07018 ? 156 ASP   B OD1 1 
ATOM   3178 O  OD2 . ASP   B 1 156 ? -23.55031 23.52543  -65.47987 1.000 28.02260 ? 156 ASP   B OD2 1 
ATOM   3179 N  N   . VAL   B 1 157 ? -23.71826 19.19501  -67.88188 1.000 19.55431 ? 157 VAL   B N   1 
ATOM   3180 C  CA  . VAL   B 1 157 ? -22.71724 18.14615  -67.73391 1.000 16.98570 ? 157 VAL   B CA  1 
ATOM   3181 C  C   . VAL   B 1 157 ? -22.75939 17.28611  -68.99721 1.000 21.73085 ? 157 VAL   B C   1 
ATOM   3182 O  O   . VAL   B 1 157 ? -23.81173 16.73185  -69.33703 1.000 21.24238 ? 157 VAL   B O   1 
ATOM   3183 C  CB  . VAL   B 1 157 ? -22.98422 17.32732  -66.45804 1.000 19.25096 ? 157 VAL   B CB  1 
ATOM   3184 C  CG1 . VAL   B 1 157 ? -22.23543 16.01153  -66.46856 1.000 19.03212 ? 157 VAL   B CG1 1 
ATOM   3185 C  CG2 . VAL   B 1 157 ? -22.61205 18.16291  -65.22819 1.000 16.57684 ? 157 VAL   B CG2 1 
ATOM   3186 N  N   . ALA   B 1 158 ? -21.61250 17.16291  -69.68878 1.000 17.08717 ? 158 ALA   B N   1 
ATOM   3187 C  CA  . ALA   B 1 158 ? -21.61107 16.67725  -71.07671 1.000 18.23844 ? 158 ALA   B CA  1 
ATOM   3188 C  C   . ALA   B 1 158 ? -21.94758 15.19007  -71.19166 1.000 19.71669 ? 158 ALA   B C   1 
ATOM   3189 O  O   . ALA   B 1 158 ? -22.56244 14.76801  -72.17748 1.000 15.86738 ? 158 ALA   B O   1 
ATOM   3190 C  CB  . ALA   B 1 158 ? -20.25427 16.94465  -71.73208 1.000 23.18233 ? 158 ALA   B CB  1 
ATOM   3191 N  N   . TYR   B 1 159 ? -21.50267 14.36422  -70.23973 1.000 15.70569 ? 159 TYR   B N   1 
ATOM   3192 C  CA  . TYR   B 1 159 ? -21.75051 12.92734  -70.31725 1.000 13.35584 ? 159 TYR   B CA  1 
ATOM   3193 C  C   . TYR   B 1 159 ? -22.73082 12.45663  -69.24916 1.000 14.75362 ? 159 TYR   B C   1 
ATOM   3194 O  O   . TYR   B 1 159 ? -23.74143 11.83158  -69.57236 1.000 13.99509 ? 159 TYR   B O   1 
ATOM   3195 C  CB  . TYR   B 1 159 ? -20.43323 12.13472  -70.21874 1.000 12.91990 ? 159 TYR   B CB  1 
ATOM   3196 C  CG  . TYR   B 1 159 ? -20.63192 10.62356  -70.33472 1.000 14.27266 ? 159 TYR   B CG  1 
ATOM   3197 C  CD1 . TYR   B 1 159 ? -20.91950 9.84661   -69.21077 1.000 13.54388 ? 159 TYR   B CD1 1 
ATOM   3198 C  CD2 . TYR   B 1 159 ? -20.54812 9.98007   -71.56880 1.000 16.09116 ? 159 TYR   B CD2 1 
ATOM   3199 C  CE1 . TYR   B 1 159 ? -21.11591 8.46987   -69.31576 1.000 15.23815 ? 159 TYR   B CE1 1 
ATOM   3200 C  CE2 . TYR   B 1 159 ? -20.74311 8.60067   -71.68885 1.000 14.98036 ? 159 TYR   B CE2 1 
ATOM   3201 C  CZ  . TYR   B 1 159 ? -21.03072 7.85090   -70.55496 1.000 16.55867 ? 159 TYR   B CZ  1 
ATOM   3202 O  OH  . TYR   B 1 159 ? -21.23833 6.48658   -70.65294 1.000 15.24881 ? 159 TYR   B OH  1 
ATOM   3203 N  N   . HIS   B 1 160 ? -22.45427 12.71857  -67.97100 1.000 13.08449 ? 160 HIS   B N   1 
ATOM   3204 C  CA  . HIS   B 1 160 ? -23.25451 12.13599  -66.89132 1.000 13.01741 ? 160 HIS   B CA  1 
ATOM   3205 C  C   . HIS   B 1 160 ? -24.52015 12.96942  -66.67927 1.000 14.87939 ? 160 HIS   B C   1 
ATOM   3206 O  O   . HIS   B 1 160 ? -24.70821 13.65396  -65.67211 1.000 16.86631 ? 160 HIS   B O   1 
ATOM   3207 C  CB  . HIS   B 1 160 ? -22.42182 12.01201  -65.62293 1.000 13.68652 ? 160 HIS   B CB  1 
ATOM   3208 C  CG  . HIS   B 1 160 ? -21.32839 10.98953  -65.71858 1.000 14.10759 ? 160 HIS   B CG  1 
ATOM   3209 N  ND1 . HIS   B 1 160 ? -20.00426 11.33258  -65.87499 1.000 13.94403 ? 160 HIS   B ND1 1 
ATOM   3210 C  CD2 . HIS   B 1 160 ? -21.36346 9.63270   -65.68828 1.000 12.90057 ? 160 HIS   B CD2 1 
ATOM   3211 C  CE1 . HIS   B 1 160 ? -19.26680 10.23408  -65.93022 1.000 14.85497 ? 160 HIS   B CE1 1 
ATOM   3212 N  NE2 . HIS   B 1 160 ? -20.06699 9.18895   -65.82694 1.000 12.03369 ? 160 HIS   B NE2 1 
ATOM   3213 N  N   . ASN   B 1 161 ? -25.40799 12.89838  -67.67141 1.000 16.69089 ? 161 ASN   B N   1 
ATOM   3214 C  CA  . ASN   B 1 161 ? -26.64705 13.65951  -67.63431 1.000 17.19978 ? 161 ASN   B CA  1 
ATOM   3215 C  C   . ASN   B 1 161 ? -27.85016 12.74567  -67.85529 1.000 17.18881 ? 161 ASN   B C   1 
ATOM   3216 O  O   . ASN   B 1 161 ? -27.71795 11.51928  -67.82181 1.000 16.71117 ? 161 ASN   B O   1 
ATOM   3217 C  CB  . ASN   B 1 161 ? -26.61132 14.77861  -68.67974 1.000 19.05863 ? 161 ASN   B CB  1 
ATOM   3218 C  CG  . ASN   B 1 161 ? -26.28992 14.26430  -70.06207 1.000 19.20376 ? 161 ASN   B CG  1 
ATOM   3219 O  OD1 . ASN   B 1 161 ? -26.94178 13.34020  -70.55872 1.000 21.04190 ? 161 ASN   B OD1 1 
ATOM   3220 N  ND2 . ASN   B 1 161 ? -25.25179 14.82610  -70.67892 1.000 15.55589 ? 161 ASN   B ND2 1 
ATOM   3221 N  N   . ASN   B 1 162 ? -29.01824 13.33755  -68.10197 1.000 16.95297 ? 162 ASN   B N   1 
ATOM   3222 C  CA  . ASN   B 1 162 ? -30.24264 12.56093  -68.27018 1.000 18.77093 ? 162 ASN   B CA  1 
ATOM   3223 C  C   . ASN   B 1 162 ? -30.19130 11.64936  -69.49675 1.000 19.71449 ? 162 ASN   B C   1 
ATOM   3224 O  O   . ASN   B 1 162 ? -30.85770 10.60426  -69.51401 1.000 17.49757 ? 162 ASN   B O   1 
ATOM   3225 C  CB  . ASN   B 1 162 ? -31.43985 13.50490  -68.36060 1.000 17.68531 ? 162 ASN   B CB  1 
ATOM   3226 C  CG  . ASN   B 1 162 ? -31.30201 14.50030  -69.49714 1.000 24.83738 ? 162 ASN   B CG  1 
ATOM   3227 O  OD1 . ASN   B 1 162 ? -30.19195 14.88473  -69.85555 1.000 23.04624 ? 162 ASN   B OD1 1 
ATOM   3228 N  ND2 . ASN   B 1 162 ? -32.42993 14.90951  -70.07881 1.000 22.11593 ? 162 ASN   B ND2 1 
ATOM   3229 N  N   . ILE   B 1 163 ? -29.40634 12.00669  -70.52122 1.000 19.64531 ? 163 ILE   B N   1 
ATOM   3230 C  CA  . ILE   B 1 163 ? -29.32768 11.16011  -71.71054 1.000 15.81501 ? 163 ILE   B CA  1 
ATOM   3231 C  C   . ILE   B 1 163 ? -28.57345 9.87835   -71.39610 1.000 18.31285 ? 163 ILE   B C   1 
ATOM   3232 O  O   . ILE   B 1 163 ? -28.93304 8.79527   -71.87541 1.000 16.17489 ? 163 ILE   B O   1 
ATOM   3233 C  CB  . ILE   B 1 163 ? -28.67964 11.91144  -72.89552 1.000 22.22139 ? 163 ILE   B CB  1 
ATOM   3234 C  CG1 . ILE   B 1 163 ? -29.31817 13.29141  -73.10551 1.000 24.29110 ? 163 ILE   B CG1 1 
ATOM   3235 C  CG2 . ILE   B 1 163 ? -28.81572 11.08778  -74.18742 1.000 20.15227 ? 163 ILE   B CG2 1 
ATOM   3236 C  CD1 . ILE   B 1 163 ? -28.70452 14.05146  -74.27945 1.000 21.77296 ? 163 ILE   B CD1 1 
ATOM   3237 N  N   . HIS   B 1 164 ? -27.50831 9.97627   -70.59763 1.000 15.78181 ? 164 HIS   B N   1 
ATOM   3238 C  CA  . HIS   B 1 164 ? -26.81899 8.76533   -70.17181 1.000 18.26649 ? 164 HIS   B CA  1 
ATOM   3239 C  C   . HIS   B 1 164 ? -27.72010 7.91749   -69.27948 1.000 15.76898 ? 164 HIS   B C   1 
ATOM   3240 O  O   . HIS   B 1 164 ? -27.74343 6.68900   -69.40567 1.000 17.09015 ? 164 HIS   B O   1 
ATOM   3241 C  CB  . HIS   B 1 164 ? -25.51306 9.12216   -69.45622 1.000 15.13454 ? 164 HIS   B CB  1 
ATOM   3242 C  CG  . HIS   B 1 164 ? -24.86384 7.96430   -68.75900 1.000 13.81251 ? 164 HIS   B CG  1 
ATOM   3243 N  ND1 . HIS   B 1 164 ? -24.25753 6.92617   -69.43381 1.000 14.16363 ? 164 HIS   B ND1 1 
ATOM   3244 C  CD2 . HIS   B 1 164 ? -24.70808 7.69502   -67.44024 1.000 15.60121 ? 164 HIS   B CD2 1 
ATOM   3245 C  CE1 . HIS   B 1 164 ? -23.76229 6.06662   -68.56254 1.000 14.20756 ? 164 HIS   B CE1 1 
ATOM   3246 N  NE2 . HIS   B 1 164 ? -24.02364 6.50950   -67.34636 1.000 12.65569 ? 164 HIS   B NE2 1 
ATOM   3247 N  N   . ALA   B 1 165 ? -28.47880 8.55709   -68.38696 1.000 12.66308 ? 165 ALA   B N   1 
ATOM   3248 C  CA  . ALA   B 1 165 ? -29.41530 7.81173   -67.54747 1.000 15.98349 ? 165 ALA   B CA  1 
ATOM   3249 C  C   . ALA   B 1 165 ? -30.43777 7.06746   -68.39767 1.000 16.56262 ? 165 ALA   B C   1 
ATOM   3250 O  O   . ALA   B 1 165 ? -30.68019 5.86878   -68.20087 1.000 16.55379 ? 165 ALA   B O   1 
ATOM   3251 C  CB  . ALA   B 1 165 ? -30.12099 8.75805   -66.56701 1.000 12.59483 ? 165 ALA   B CB  1 
ATOM   3252 N  N   . ALA   B 1 166 ? -31.06563 7.77324   -69.33656 1.000 18.18813 ? 166 ALA   B N   1 
ATOM   3253 C  CA  . ALA   B 1 166 ? -32.01745 7.12603   -70.23566 1.000 17.72599 ? 166 ALA   B CA  1 
ATOM   3254 C  C   . ALA   B 1 166 ? -31.36676 5.96627   -70.97690 1.000 16.53741 ? 166 ALA   B C   1 
ATOM   3255 O  O   . ALA   B 1 166 ? -31.98030 4.90198   -71.14823 1.000 19.25851 ? 166 ALA   B O   1 
ATOM   3256 C  CB  . ALA   B 1 166 ? -32.58450 8.15678   -71.21868 1.000 15.29269 ? 166 ALA   B CB  1 
ATOM   3257 N  N   . ASP   B 1 167 ? -30.10586 6.14312   -71.39072 1.000 18.09123 ? 167 ASP   B N   1 
ATOM   3258 C  CA  . ASP   B 1 167 ? -29.40348 5.12130   -72.15857 1.000 18.43498 ? 167 ASP   B CA  1 
ATOM   3259 C  C   . ASP   B 1 167 ? -29.10853 3.88568   -71.31534 1.000 20.56712 ? 167 ASP   B C   1 
ATOM   3260 O  O   . ASP   B 1 167 ? -29.23383 2.75068   -71.79863 1.000 17.91587 ? 167 ASP   B O   1 
ATOM   3261 C  CB  . ASP   B 1 167 ? -28.11429 5.72422   -72.72324 1.000 19.76668 ? 167 ASP   B CB  1 
ATOM   3262 C  CG  . ASP   B 1 167 ? -27.29103 4.73677   -73.52618 1.000 19.84405 ? 167 ASP   B CG  1 
ATOM   3263 O  OD1 . ASP   B 1 167 ? -27.86893 3.94560   -74.30035 1.000 21.98995 ? 167 ASP   B OD1 1 
ATOM   3264 O  OD2 . ASP   B 1 167 ? -26.04414 4.76393   -73.38922 1.000 20.35533 ? 167 ASP   B OD2 1 
ATOM   3265 N  N   . VAL   B 1 168 ? -28.68017 4.07715   -70.06223 1.000 16.95886 ? 168 VAL   B N   1 
ATOM   3266 C  CA  . VAL   B 1 168 ? -28.40101 2.92053   -69.20789 1.000 14.25927 ? 168 VAL   B CA  1 
ATOM   3267 C  C   . VAL   B 1 168 ? -29.69817 2.18166   -68.87912 1.000 18.09174 ? 168 VAL   B C   1 
ATOM   3268 O  O   . VAL   B 1 168 ? -29.74345 0.94161   -68.86411 1.000 19.74494 ? 168 VAL   B O   1 
ATOM   3269 C  CB  . VAL   B 1 168 ? -27.65108 3.36514   -67.93576 1.000 16.06590 ? 168 VAL   B CB  1 
ATOM   3270 C  CG1 . VAL   B 1 168 ? -27.55831 2.20471   -66.91477 1.000 14.79184 ? 168 VAL   B CG1 1 
ATOM   3271 C  CG2 . VAL   B 1 168 ? -26.25448 3.87562   -68.30286 1.000 17.50780 ? 168 VAL   B CG2 1 
ATOM   3272 N  N   . VAL   B 1 169 ? -30.76775 2.93789   -68.62621 1.000 14.93149 ? 169 VAL   B N   1 
ATOM   3273 C  CA  . VAL   B 1 169 ? -32.09510 2.36336   -68.40589 1.000 19.69856 ? 169 VAL   B CA  1 
ATOM   3274 C  C   . VAL   B 1 169 ? -32.47338 1.44204   -69.55729 1.000 23.11931 ? 169 VAL   B C   1 
ATOM   3275 O  O   . VAL   B 1 169 ? -32.72347 0.24268   -69.37247 1.000 22.43642 ? 169 VAL   B O   1 
ATOM   3276 C  CB  . VAL   B 1 169 ? -33.13898 3.47893   -68.24186 1.000 17.73357 ? 169 VAL   B CB  1 
ATOM   3277 C  CG1 . VAL   B 1 169 ? -34.53187 2.93769   -68.50818 1.000 24.29315 ? 169 VAL   B CG1 1 
ATOM   3278 C  CG2 . VAL   B 1 169 ? -33.08549 4.04166   -66.85832 1.000 21.32705 ? 169 VAL   B CG2 1 
ATOM   3279 N  N   . GLN   B 1 170 ? -32.53554 2.00812   -70.76625 1.000 24.56338 ? 170 GLN   B N   1 
ATOM   3280 C  CA  . GLN   B 1 170 ? -32.95445 1.23915   -71.92495 1.000 20.49837 ? 170 GLN   B CA  1 
ATOM   3281 C  C   . GLN   B 1 170 ? -31.99775 0.09363   -72.19667 1.000 22.36529 ? 170 GLN   B C   1 
ATOM   3282 O  O   . GLN   B 1 170 ? -32.42652 -0.97925  -72.63835 1.000 22.11885 ? 170 GLN   B O   1 
ATOM   3283 C  CB  . GLN   B 1 170 ? -33.08395 2.15944   -73.14091 1.000 25.57252 ? 170 GLN   B CB  1 
ATOM   3284 C  CG  . GLN   B 1 170 ? -33.68720 1.48410   -74.38507 1.000 27.79903 ? 170 GLN   B CG  1 
ATOM   3285 C  CD  . GLN   B 1 170 ? -32.63173 0.96570   -75.33979 1.000 29.39181 ? 170 GLN   B CD  1 
ATOM   3286 O  OE1 . GLN   B 1 170 ? -31.48518 1.41094   -75.30559 1.000 24.77469 ? 170 GLN   B OE1 1 
ATOM   3287 N  NE2 . GLN   B 1 170 ? -33.01232 0.02158   -76.20025 1.000 26.51593 ? 170 GLN   B NE2 1 
ATOM   3288 N  N   . SER   B 1 171 ? -30.70627 0.27895   -71.91345 1.000 21.08040 ? 171 SER   B N   1 
ATOM   3289 C  CA  . SER   B 1 171 ? -29.76352 -0.81472  -72.11989 1.000 18.39495 ? 171 SER   B CA  1 
ATOM   3290 C  C   . SER   B 1 171 ? -30.03887 -1.97027  -71.16104 1.000 24.17847 ? 171 SER   B C   1 
ATOM   3291 O  O   . SER   B 1 171 ? -30.09908 -3.13376  -71.58134 1.000 19.55102 ? 171 SER   B O   1 
ATOM   3292 C  CB  . SER   B 1 171 ? -28.32579 -0.31199  -71.98527 1.000 18.32930 ? 171 SER   B CB  1 
ATOM   3293 O  OG  . SER   B 1 171 ? -28.05985 0.68397   -72.96604 1.000 20.13772 ? 171 SER   B OG  1 
ATOM   3294 N  N   . THR   B 1 172 ? -30.21229 -1.66436  -69.86856 1.000 20.78553 ? 172 THR   B N   1 
ATOM   3295 C  CA  . THR   B 1 172 ? -30.59666 -2.68605  -68.89511 1.000 23.83675 ? 172 THR   B CA  1 
ATOM   3296 C  C   . THR   B 1 172 ? -31.88707 -3.38240  -69.30932 1.000 20.45747 ? 172 THR   B C   1 
ATOM   3297 O  O   . THR   B 1 172 ? -32.00381 -4.60991  -69.20850 1.000 21.80001 ? 172 THR   B O   1 
ATOM   3298 C  CB  . THR   B 1 172 ? -30.76321 -2.04537  -67.51217 1.000 20.52242 ? 172 THR   B CB  1 
ATOM   3299 O  OG1 . THR   B 1 172 ? -29.51369 -1.48203  -67.09471 1.000 19.93364 ? 172 THR   B OG1 1 
ATOM   3300 C  CG2 . THR   B 1 172 ? -31.23685 -3.07190  -66.48785 1.000 15.21538 ? 172 THR   B CG2 1 
ATOM   3301 N  N   . HIS   B 1 173 ? -32.86733 -2.60111  -69.76288 1.000 20.66557 ? 173 HIS   B N   1 
ATOM   3302 C  CA  . HIS   B 1 173 ? -34.13494 -3.15547  -70.22118 1.000 24.56876 ? 173 HIS   B CA  1 
ATOM   3303 C  C   . HIS   B 1 173 ? -33.92806 -4.21884  -71.29570 1.000 32.16558 ? 173 HIS   B C   1 
ATOM   3304 O  O   . HIS   B 1 173 ? -34.63150 -5.23500  -71.30871 1.000 28.95334 ? 173 HIS   B O   1 
ATOM   3305 C  CB  . HIS   B 1 173 ? -35.02790 -2.03017  -70.73328 1.000 22.01470 ? 173 HIS   B CB  1 
ATOM   3306 C  CG  . HIS   B 1 173 ? -36.21151 -2.49823  -71.52489 1.000 31.17864 ? 173 HIS   B CG  1 
ATOM   3307 N  ND1 . HIS   B 1 173 ? -37.31881 -3.07517  -70.94072 1.000 30.67286 ? 173 HIS   B ND1 1 
ATOM   3308 C  CD2 . HIS   B 1 173 ? -36.46780 -2.45774  -72.85517 1.000 31.95038 ? 173 HIS   B CD2 1 
ATOM   3309 C  CE1 . HIS   B 1 173 ? -38.20237 -3.37778  -71.87491 1.000 33.07408 ? 173 HIS   B CE1 1 
ATOM   3310 N  NE2 . HIS   B 1 173 ? -37.70990 -3.01496  -73.04602 1.000 34.88821 ? 173 HIS   B NE2 1 
ATOM   3311 N  N   . VAL   B 1 174 ? -32.96600 -4.00548  -72.20221 1.000 24.99792 ? 174 VAL   B N   1 
ATOM   3312 C  CA  . VAL   B 1 174 ? -32.69032 -4.99041  -73.24157 1.000 24.10931 ? 174 VAL   B CA  1 
ATOM   3313 C  C   . VAL   B 1 174 ? -32.03288 -6.22773  -72.64638 1.000 26.74900 ? 174 VAL   B C   1 
ATOM   3314 O  O   . VAL   B 1 174 ? -32.41076 -7.36047  -72.96231 1.000 23.55543 ? 174 VAL   B O   1 
ATOM   3315 C  CB  . VAL   B 1 174 ? -31.81937 -4.37788  -74.35651 1.000 26.23843 ? 174 VAL   B CB  1 
ATOM   3316 C  CG1 . VAL   B 1 174 ? -31.28616 -5.46372  -75.26940 1.000 26.44178 ? 174 VAL   B CG1 1 
ATOM   3317 C  CG2 . VAL   B 1 174 ? -32.61057 -3.37037  -75.14636 1.000 27.10582 ? 174 VAL   B CG2 1 
ATOM   3318 N  N   . LEU   B 1 175 ? -31.02326 -6.03364  -71.79388 1.000 21.96049 ? 175 LEU   B N   1 
ATOM   3319 C  CA  . LEU   B 1 175 ? -30.28464 -7.16607  -71.25132 1.000 22.80803 ? 175 LEU   B CA  1 
ATOM   3320 C  C   . LEU   B 1 175 ? -31.14188 -8.03090  -70.33430 1.000 24.87733 ? 175 LEU   B C   1 
ATOM   3321 O  O   . LEU   B 1 175 ? -30.83284 -9.20770  -70.15234 1.000 24.19978 ? 175 LEU   B O   1 
ATOM   3322 C  CB  . LEU   B 1 175 ? -29.05207 -6.68139  -70.48670 1.000 21.79450 ? 175 LEU   B CB  1 
ATOM   3323 C  CG  . LEU   B 1 175 ? -28.08175 -5.82004  -71.30026 1.000 27.98285 ? 175 LEU   B CG  1 
ATOM   3324 C  CD1 . LEU   B 1 175 ? -26.96064 -5.28553  -70.42870 1.000 19.33703 ? 175 LEU   B CD1 1 
ATOM   3325 C  CD2 . LEU   B 1 175 ? -27.51913 -6.64240  -72.44267 1.000 25.43557 ? 175 LEU   B CD2 1 
ATOM   3326 N  N   . LEU   B 1 176 ? -32.18671 -7.46577  -69.72941 1.000 26.87454 ? 176 LEU   B N   1 
ATOM   3327 C  CA  . LEU   B 1 176 ? -33.08266 -8.26538  -68.90276 1.000 27.12144 ? 176 LEU   B CA  1 
ATOM   3328 C  C   . LEU   B 1 176 ? -33.84838 -9.28864  -69.73334 1.000 32.22631 ? 176 LEU   B C   1 
ATOM   3329 O  O   . LEU   B 1 176 ? -34.27868 -10.31904 -69.20360 1.000 31.96070 ? 176 LEU   B O   1 
ATOM   3330 C  CB  . LEU   B 1 176 ? -34.06290 -7.35082  -68.16558 1.000 23.73906 ? 176 LEU   B CB  1 
ATOM   3331 C  CG  . LEU   B 1 176 ? -33.51868 -6.60173  -66.94587 1.000 25.87730 ? 176 LEU   B CG  1 
ATOM   3332 C  CD1 . LEU   B 1 176 ? -34.46739 -5.47965  -66.53048 1.000 25.25463 ? 176 LEU   B CD1 1 
ATOM   3333 C  CD2 . LEU   B 1 176 ? -33.27867 -7.56676  -65.80422 1.000 25.74604 ? 176 LEU   B CD2 1 
ATOM   3334 N  N   . SER   B 1 177 ? -34.02872 -9.02657  -71.02730 1.000 32.46344 ? 177 SER   B N   1 
ATOM   3335 C  CA  . SER   B 1 177 ? -34.84983 -9.87457  -71.87927 1.000 30.90279 ? 177 SER   B CA  1 
ATOM   3336 C  C   . SER   B 1 177 ? -34.04259 -10.85983 -72.69952 1.000 30.00796 ? 177 SER   B C   1 
ATOM   3337 O  O   . SER   B 1 177 ? -34.60261 -11.50267 -73.58960 1.000 38.21371 ? 177 SER   B O   1 
ATOM   3338 C  CB  . SER   B 1 177 ? -35.71272 -9.01855  -72.79918 1.000 31.29987 ? 177 SER   B CB  1 
ATOM   3339 O  OG  . SER   B 1 177 ? -36.51553 -8.15885  -72.01983 1.000 35.34135 ? 177 SER   B OG  1 
ATOM   3340 N  N   . THR   B 1 178 ? -32.75694 -11.00771 -72.41988 1.000 27.57713 ? 178 THR   B N   1 
ATOM   3341 C  CA  . THR   B 1 178 ? -31.96689 -12.00970 -73.11709 1.000 33.69234 ? 178 THR   B CA  1 
ATOM   3342 C  C   . THR   B 1 178 ? -32.56908 -13.39374 -72.87363 1.000 41.54294 ? 178 THR   B C   1 
ATOM   3343 O  O   . THR   B 1 178 ? -32.87387 -13.73517 -71.72073 1.000 38.00870 ? 178 THR   B O   1 
ATOM   3344 C  CB  . THR   B 1 178 ? -30.50253 -11.95226 -72.65997 1.000 29.67256 ? 178 THR   B CB  1 
ATOM   3345 O  OG1 . THR   B 1 178 ? -29.80488 -13.12256 -73.08253 1.000 39.80366 ? 178 THR   B OG1 1 
ATOM   3346 C  CG2 . THR   B 1 178 ? -30.39908 -11.88554 -71.18682 1.000 40.45408 ? 178 THR   B CG2 1 
ATOM   3347 N  N   . PRO   B 1 179 ? -32.79816 -14.19598 -73.92678 1.000 45.56975 ? 179 PRO   B N   1 
ATOM   3348 C  CA  . PRO   B 1 179 ? -33.36055 -15.54786 -73.72432 1.000 40.14598 ? 179 PRO   B CA  1 
ATOM   3349 C  C   . PRO   B 1 179 ? -32.70380 -16.34320 -72.59911 1.000 42.65019 ? 179 PRO   B C   1 
ATOM   3350 O  O   . PRO   B 1 179 ? -33.41356 -16.96865 -71.80166 1.000 44.41882 ? 179 PRO   B O   1 
ATOM   3351 C  CB  . PRO   B 1 179 ? -33.14368 -16.21319 -75.09238 1.000 37.75703 ? 179 PRO   B CB  1 
ATOM   3352 C  CG  . PRO   B 1 179 ? -33.23578 -15.08431 -76.06364 1.000 39.15745 ? 179 PRO   B CG  1 
ATOM   3353 C  CD  . PRO   B 1 179 ? -32.64165 -13.87085 -75.35873 1.000 40.65507 ? 179 PRO   B CD  1 
ATOM   3354 N  N   . ALA   B 1 180 ? -31.37485 -16.31945 -72.49163 1.000 36.87750 ? 180 ALA   B N   1 
ATOM   3355 C  CA  . ALA   B 1 180 ? -30.66397 -17.08821 -71.47305 1.000 41.72290 ? 180 ALA   B CA  1 
ATOM   3356 C  C   . ALA   B 1 180 ? -30.94860 -16.61700 -70.04604 1.000 47.69212 ? 180 ALA   B C   1 
ATOM   3357 O  O   . ALA   B 1 180 ? -30.39514 -17.19942 -69.10496 1.000 43.30864 ? 180 ALA   B O   1 
ATOM   3358 C  CB  . ALA   B 1 180 ? -29.15817 -17.04548 -71.74405 1.000 35.60270 ? 180 ALA   B CB  1 
ATOM   3359 N  N   . LEU   B 1 181 ? -31.78290 -15.58772 -69.86598 1.000 45.29697 ? 181 LEU   B N   1 
ATOM   3360 C  CA  . LEU   B 1 181 ? -32.19748 -15.10517 -68.55302 1.000 50.05763 ? 181 LEU   B CA  1 
ATOM   3361 C  C   . LEU   B 1 181 ? -33.71159 -15.02115 -68.44670 1.000 56.17883 ? 181 LEU   B C   1 
ATOM   3362 O  O   . LEU   B 1 181 ? -34.22266 -14.24875 -67.62512 1.000 53.95754 ? 181 LEU   B O   1 
ATOM   3363 C  CB  . LEU   B 1 181 ? -31.59644 -13.72735 -68.24603 1.000 40.44108 ? 181 LEU   B CB  1 
ATOM   3364 C  CG  . LEU   B 1 181 ? -30.08325 -13.55571 -68.11657 1.000 38.02097 ? 181 LEU   B CG  1 
ATOM   3365 C  CD1 . LEU   B 1 181 ? -29.71488 -12.09850 -67.76572 1.000 36.07472 ? 181 LEU   B CD1 1 
ATOM   3366 C  CD2 . LEU   B 1 181 ? -29.50981 -14.51302 -67.10557 1.000 39.49712 ? 181 LEU   B CD2 1 
ATOM   3367 N  N   . GLU   B 1 182 ? -34.43582 -15.78625 -69.27377 1.000 55.55163 ? 182 GLU   B N   1 
ATOM   3368 C  CA  . GLU   B 1 182 ? -35.87930 -15.60546 -69.40590 1.000 64.33133 ? 182 GLU   B CA  1 
ATOM   3369 C  C   . GLU   B 1 182 ? -36.56439 -15.79322 -68.06353 1.000 64.68727 ? 182 GLU   B C   1 
ATOM   3370 O  O   . GLU   B 1 182 ? -36.52368 -16.88419 -67.48297 1.000 60.65643 ? 182 GLU   B O   1 
ATOM   3371 C  CB  . GLU   B 1 182 ? -36.46992 -16.57862 -70.42557 1.000 62.12996 ? 182 GLU   B CB  1 
ATOM   3372 C  CG  . GLU   B 1 182 ? -37.98250 -16.39236 -70.59691 1.000 64.48904 ? 182 GLU   B CG  1 
ATOM   3373 C  CD  . GLU   B 1 182 ? -38.68809 -17.62525 -71.14095 1.000 71.56546 ? 182 GLU   B CD  1 
ATOM   3374 O  OE1 . GLU   B 1 182 ? -39.32363 -18.36197 -70.34676 1.000 56.94345 ? 182 GLU   B OE1 1 
ATOM   3375 O  OE2 . GLU   B 1 182 ? -38.61475 -17.85104 -72.36753 1.000 78.69002 ? 182 GLU   B OE2 1 
ATOM   3376 N  N   . ALA   B 1 183 ? -37.18741 -14.72014 -67.57508 1.000 60.08084 ? 183 ALA   B N   1 
ATOM   3377 C  CA  . ALA   B 1 183 ? -37.86519 -14.73486 -66.28581 1.000 61.80442 ? 183 ALA   B CA  1 
ATOM   3378 C  C   . ALA   B 1 183 ? -37.00982 -15.39233 -65.20117 1.000 56.76089 ? 183 ALA   B C   1 
ATOM   3379 O  O   . ALA   B 1 183 ? -37.53134 -16.11875 -64.34746 1.000 57.30336 ? 183 ALA   B O   1 
ATOM   3380 C  CB  . ALA   B 1 183 ? -39.21847 -15.43662 -66.42311 1.000 61.64289 ? 183 ALA   B CB  1 
ATOM   3381 N  N   . VAL   B 1 184 ? -35.68938 -15.17417 -65.25218 1.000 53.32894 ? 184 VAL   B N   1 
ATOM   3382 C  CA  . VAL   B 1 184 ? -34.82013 -15.54706 -64.13752 1.000 49.94952 ? 184 VAL   B CA  1 
ATOM   3383 C  C   . VAL   B 1 184 ? -35.12885 -14.67527 -62.93267 1.000 43.20077 ? 184 VAL   B C   1 
ATOM   3384 O  O   . VAL   B 1 184 ? -35.00147 -15.10662 -61.77918 1.000 42.32820 ? 184 VAL   B O   1 
ATOM   3385 C  CB  . VAL   B 1 184 ? -33.33738 -15.42595 -64.54781 1.000 47.30944 ? 184 VAL   B CB  1 
ATOM   3386 C  CG1 . VAL   B 1 184 ? -32.43307 -15.29938 -63.33052 1.000 39.43490 ? 184 VAL   B CG1 1 
ATOM   3387 C  CG2 . VAL   B 1 184 ? -32.91716 -16.61199 -65.37448 1.000 48.75957 ? 184 VAL   B CG2 1 
ATOM   3388 N  N   . PHE   B 1 185 ? -35.56284 -13.45112 -63.18229 1.000 44.05976 ? 185 PHE   B N   1 
ATOM   3389 C  CA  . PHE   B 1 185 ? -35.71463 -12.44214 -62.15744 1.000 40.27239 ? 185 PHE   B CA  1 
ATOM   3390 C  C   . PHE   B 1 185 ? -37.18929 -12.14620 -61.95141 1.000 40.02842 ? 185 PHE   B C   1 
ATOM   3391 O  O   . PHE   B 1 185 ? -37.95938 -12.06172 -62.91472 1.000 38.40086 ? 185 PHE   B O   1 
ATOM   3392 C  CB  . PHE   B 1 185 ? -34.95947 -11.16223 -62.53816 1.000 35.54130 ? 185 PHE   B CB  1 
ATOM   3393 C  CG  . PHE   B 1 185 ? -33.48595 -11.37027 -62.73366 1.000 30.54124 ? 185 PHE   B CG  1 
ATOM   3394 C  CD1 . PHE   B 1 185 ? -32.64976 -11.56300 -61.64584 1.000 29.55735 ? 185 PHE   B CD1 1 
ATOM   3395 C  CD2 . PHE   B 1 185 ? -32.93473 -11.36206 -64.00073 1.000 28.86396 ? 185 PHE   B CD2 1 
ATOM   3396 C  CE1 . PHE   B 1 185 ? -31.29450 -11.75639 -61.81885 1.000 30.82088 ? 185 PHE   B CE1 1 
ATOM   3397 C  CE2 . PHE   B 1 185 ? -31.58681 -11.55576 -64.17899 1.000 27.82270 ? 185 PHE   B CE2 1 
ATOM   3398 C  CZ  . PHE   B 1 185 ? -30.76102 -11.75667 -63.09204 1.000 28.06434 ? 185 PHE   B CZ  1 
ATOM   3399 N  N   . THR   B 1 186 ? -37.57092 -11.99720 -60.68698 1.000 38.36184 ? 186 THR   B N   1 
ATOM   3400 C  CA  . THR   B 1 186 ? -38.92808 -11.62443 -60.34599 1.000 34.16261 ? 186 THR   B CA  1 
ATOM   3401 C  C   . THR   B 1 186 ? -39.24769 -10.24595 -60.91275 1.000 36.36409 ? 186 THR   B C   1 
ATOM   3402 O  O   . THR   B 1 186 ? -38.37299 -9.51606  -61.38864 1.000 39.70493 ? 186 THR   B O   1 
ATOM   3403 C  CB  . THR   B 1 186 ? -39.10542 -11.62453 -58.83053 1.000 37.59738 ? 186 THR   B CB  1 
ATOM   3404 O  OG1 . THR   B 1 186 ? -38.58112 -10.40325 -58.29330 1.000 33.08053 ? 186 THR   B OG1 1 
ATOM   3405 C  CG2 . THR   B 1 186 ? -38.34260 -12.79516 -58.21868 1.000 30.30899 ? 186 THR   B CG2 1 
ATOM   3406 N  N   . ASP   B 1 187 ? -40.53004 -9.89004  -60.85816 1.000 31.67858 ? 187 ASP   B N   1 
ATOM   3407 C  CA  . ASP   B 1 187 ? -40.93331 -8.54498  -61.24917 1.000 38.65185 ? 187 ASP   B CA  1 
ATOM   3408 C  C   . ASP   B 1 187 ? -40.35383 -7.48901  -60.31320 1.000 39.91625 ? 187 ASP   B C   1 
ATOM   3409 O  O   . ASP   B 1 187 ? -40.17777 -6.33409  -60.71638 1.000 32.40909 ? 187 ASP   B O   1 
ATOM   3410 C  CB  . ASP   B 1 187 ? -42.45258 -8.44212  -61.27434 1.000 38.72740 ? 187 ASP   B CB  1 
ATOM   3411 C  CG  . ASP   B 1 187 ? -43.08824 -9.48631  -62.16009 1.000 44.23593 ? 187 ASP   B CG  1 
ATOM   3412 O  OD1 . ASP   B 1 187 ? -42.34504 -10.20899 -62.85956 1.000 42.69043 ? 187 ASP   B OD1 1 
ATOM   3413 O  OD2 . ASP   B 1 187 ? -44.33443 -9.57453  -62.16013 1.000 48.25020 ? 187 ASP   B OD2 1 
ATOM   3414 N  N   . LEU   B 1 188 ? -40.07263 -7.85825  -59.06142 1.000 35.26005 ? 188 LEU   B N   1 
ATOM   3415 C  CA  . LEU   B 1 188 ? -39.44774 -6.91393  -58.14561 1.000 36.68262 ? 188 LEU   B CA  1 
ATOM   3416 C  C   . LEU   B 1 188 ? -37.98733 -6.69276  -58.51114 1.000 34.73252 ? 188 LEU   B C   1 
ATOM   3417 O  O   . LEU   B 1 188 ? -37.50828 -5.55078  -58.50786 1.000 29.00215 ? 188 LEU   B O   1 
ATOM   3418 C  CB  . LEU   B 1 188 ? -39.56832 -7.41529  -56.70860 1.000 33.24418 ? 188 LEU   B CB  1 
ATOM   3419 C  CG  . LEU   B 1 188 ? -39.26868 -6.40001  -55.60891 1.000 27.09963 ? 188 LEU   B CG  1 
ATOM   3420 C  CD1 . LEU   B 1 188 ? -40.35484 -5.34191  -55.55610 1.000 21.31630 ? 188 LEU   B CD1 1 
ATOM   3421 C  CD2 . LEU   B 1 188 ? -39.14799 -7.12754  -54.28358 1.000 24.98139 ? 188 LEU   B CD2 1 
ATOM   3422 N  N   . GLU   B 1 189 ? -37.26922 -7.78103  -58.82170 1.000 31.83628 ? 189 GLU   B N   1 
ATOM   3423 C  CA  . GLU   B 1 189 ? -35.88905 -7.67499  -59.27416 1.000 30.81909 ? 189 GLU   B CA  1 
ATOM   3424 C  C   . GLU   B 1 189 ? -35.79191 -6.91104  -60.59486 1.000 34.23930 ? 189 GLU   B C   1 
ATOM   3425 O  O   . GLU   B 1 189 ? -34.81976 -6.17682  -60.81831 1.000 28.62690 ? 189 GLU   B O   1 
ATOM   3426 C  CB  . GLU   B 1 189 ? -35.28060 -9.07681  -59.38543 1.000 30.15834 ? 189 GLU   B CB  1 
ATOM   3427 C  CG  . GLU   B 1 189 ? -35.25525 -9.83899  -58.04615 1.000 33.12525 ? 189 GLU   B CG  1 
ATOM   3428 C  CD  . GLU   B 1 189 ? -34.90730 -11.32944 -58.17903 1.000 39.06509 ? 189 GLU   B CD  1 
ATOM   3429 O  OE1 . GLU   B 1 189 ? -35.32452 -11.95698 -59.17302 1.000 36.84530 ? 189 GLU   B OE1 1 
ATOM   3430 O  OE2 . GLU   B 1 189 ? -34.22515 -11.87958 -57.28054 1.000 34.13602 ? 189 GLU   B OE2 1 
ATOM   3431 N  N   . ILE   B 1 190 ? -36.80102 -7.03587  -61.46197 1.000 29.43068 ? 190 ILE   B N   1 
ATOM   3432 C  CA  . ILE   B 1 190 ? -36.81296 -6.27042  -62.70770 1.000 31.24517 ? 190 ILE   B CA  1 
ATOM   3433 C  C   . ILE   B 1 190 ? -37.07182 -4.79001  -62.42739 1.000 30.99754 ? 190 ILE   B C   1 
ATOM   3434 O  O   . ILE   B 1 190 ? -36.42080 -3.90726  -63.00696 1.000 25.89731 ? 190 ILE   B O   1 
ATOM   3435 C  CB  . ILE   B 1 190 ? -37.85208 -6.86129  -63.68530 1.000 31.32286 ? 190 ILE   B CB  1 
ATOM   3436 C  CG1 . ILE   B 1 190 ? -37.41242 -8.23764  -64.19425 1.000 31.21779 ? 190 ILE   B CG1 1 
ATOM   3437 C  CG2 . ILE   B 1 190 ? -38.09026 -5.92902  -64.86273 1.000 31.58665 ? 190 ILE   B CG2 1 
ATOM   3438 C  CD1 . ILE   B 1 190 ? -38.51266 -8.95868  -64.97928 1.000 33.51483 ? 190 ILE   B CD1 1 
ATOM   3439 N  N   . LEU   B 1 191 ? -38.02763 -4.49317  -61.54150 1.000 24.07538 ? 191 LEU   B N   1 
ATOM   3440 C  CA  . LEU   B 1 191 ? -38.24175 -3.11585  -61.11236 1.000 26.17845 ? 191 LEU   B CA  1 
ATOM   3441 C  C   . LEU   B 1 191 ? -36.98562 -2.53032  -60.47022 1.000 26.18696 ? 191 LEU   B C   1 
ATOM   3442 O  O   . LEU   B 1 191 ? -36.70701 -1.33419  -60.61687 1.000 24.75375 ? 191 LEU   B O   1 
ATOM   3443 C  CB  . LEU   B 1 191 ? -39.41471 -3.05295  -60.13506 1.000 25.51153 ? 191 LEU   B CB  1 
ATOM   3444 C  CG  . LEU   B 1 191 ? -39.81224 -1.68119  -59.59962 1.000 27.38566 ? 191 LEU   B CG  1 
ATOM   3445 C  CD1 . LEU   B 1 191 ? -40.37029 -0.78985  -60.72089 1.000 21.27005 ? 191 LEU   B CD1 1 
ATOM   3446 C  CD2 . LEU   B 1 191 ? -40.82722 -1.84478  -58.47997 1.000 25.46830 ? 191 LEU   B CD2 1 
ATOM   3447 N  N   . ALA   B 1 192 ? -36.21910 -3.36077  -59.75696 1.000 23.27537 ? 192 ALA   B N   1 
ATOM   3448 C  CA  . ALA   B 1 192 ? -35.04618 -2.88024  -59.03028 1.000 25.35019 ? 192 ALA   B CA  1 
ATOM   3449 C  C   . ALA   B 1 192 ? -33.94540 -2.44404  -59.98507 1.000 21.46434 ? 192 ALA   B C   1 
ATOM   3450 O  O   . ALA   B 1 192 ? -33.40502 -1.33871  -59.86218 1.000 21.80731 ? 192 ALA   B O   1 
ATOM   3451 C  CB  . ALA   B 1 192 ? -34.52825 -3.96967  -58.09027 1.000 20.31544 ? 192 ALA   B CB  1 
ATOM   3452 N  N   . ALA   B 1 193 ? -33.59697 -3.31517  -60.93658 1.000 19.00890 ? 193 ALA   B N   1 
ATOM   3453 C  CA  . ALA   B 1 193 ? -32.55757 -3.01615  -61.91689 1.000 22.94439 ? 193 ALA   B CA  1 
ATOM   3454 C  C   . ALA   B 1 193 ? -32.91574 -1.82575  -62.80597 1.000 19.21994 ? 193 ALA   B C   1 
ATOM   3455 O  O   . ALA   B 1 193 ? -32.02385 -1.06211  -63.20053 1.000 20.49614 ? 193 ALA   B O   1 
ATOM   3456 C  CB  . ALA   B 1 193 ? -32.29005 -4.25372  -62.77361 1.000 23.78799 ? 193 ALA   B CB  1 
ATOM   3457 N  N   . ILE   B 1 194 ? -34.19724 -1.65762  -63.14961 1.000 19.43461 ? 194 ILE   B N   1 
ATOM   3458 C  CA  . ILE   B 1 194 ? -34.59859 -0.53124  -63.99374 1.000 19.88953 ? 194 ILE   B CA  1 
ATOM   3459 C  C   . ILE   B 1 194 ? -34.60373 0.76343   -63.18886 1.000 20.23502 ? 194 ILE   B C   1 
ATOM   3460 O  O   . ILE   B 1 194 ? -34.10238 1.80293   -63.64044 1.000 19.13117 ? 194 ILE   B O   1 
ATOM   3461 C  CB  . ILE   B 1 194 ? -35.97477 -0.78412  -64.63581 1.000 23.06042 ? 194 ILE   B CB  1 
ATOM   3462 C  CG1 . ILE   B 1 194 ? -35.91988 -1.91517  -65.66326 1.000 24.37420 ? 194 ILE   B CG1 1 
ATOM   3463 C  CG2 . ILE   B 1 194 ? -36.48464 0.49236   -65.28518 1.000 21.14516 ? 194 ILE   B CG2 1 
ATOM   3464 C  CD1 . ILE   B 1 194 ? -37.29917 -2.35534  -66.12755 1.000 26.06678 ? 194 ILE   B CD1 1 
ATOM   3465 N  N   . PHE   B 1 195 ? -35.18622 0.72554   -61.99010 1.000 15.78869 ? 195 PHE   B N   1 
ATOM   3466 C  CA  . PHE   B 1 195 ? -35.15432 1.90272   -61.13356 1.000 18.43948 ? 195 PHE   B CA  1 
ATOM   3467 C  C   . PHE   B 1 195 ? -33.72078 2.30247   -60.80206 1.000 13.06254 ? 195 PHE   B C   1 
ATOM   3468 O  O   . PHE   B 1 195 ? -33.38441 3.49094   -60.83022 1.000 14.60957 ? 195 PHE   B O   1 
ATOM   3469 C  CB  . PHE   B 1 195 ? -35.95000 1.65555   -59.85039 1.000 15.23147 ? 195 PHE   B CB  1 
ATOM   3470 C  CG  . PHE   B 1 195 ? -35.97038 2.83360   -58.92688 1.000 14.09557 ? 195 PHE   B CG  1 
ATOM   3471 C  CD1 . PHE   B 1 195 ? -36.78814 3.91409   -59.18719 1.000 17.12489 ? 195 PHE   B CD1 1 
ATOM   3472 C  CD2 . PHE   B 1 195 ? -35.17797 2.85549   -57.79867 1.000 14.71100 ? 195 PHE   B CD2 1 
ATOM   3473 C  CE1 . PHE   B 1 195 ? -36.82134 5.00841   -58.33560 1.000 22.26095 ? 195 PHE   B CE1 1 
ATOM   3474 C  CE2 . PHE   B 1 195 ? -35.19105 3.93633   -56.94587 1.000 16.38708 ? 195 PHE   B CE2 1 
ATOM   3475 C  CZ  . PHE   B 1 195 ? -36.00780 5.01997   -57.20727 1.000 20.72441 ? 195 PHE   B CZ  1 
ATOM   3476 N  N   . ALA   B 1 196 ? -32.85919 1.32286   -60.49436 1.000 15.40464 ? 196 ALA   B N   1 
ATOM   3477 C  CA  . ALA   B 1 196 ? -31.48075 1.65191   -60.13817 1.000 15.84193 ? 196 ALA   B CA  1 
ATOM   3478 C  C   . ALA   B 1 196 ? -30.74679 2.27110   -61.32160 1.000 15.59670 ? 196 ALA   B C   1 
ATOM   3479 O  O   . ALA   B 1 196 ? -30.02475 3.26547   -61.16180 1.000 16.28707 ? 196 ALA   B O   1 
ATOM   3480 C  CB  . ALA   B 1 196 ? -30.75350 0.40879   -59.62678 1.000 14.53973 ? 196 ALA   B CB  1 
ATOM   3481 N  N   . SER   B 1 197 ? -30.95171 1.71228   -62.52332 1.000 14.09087 ? 197 SER   B N   1 
ATOM   3482 C  CA  . SER   B 1 197 ? -30.39526 2.28786   -63.74812 1.000 15.56915 ? 197 SER   B CA  1 
ATOM   3483 C  C   . SER   B 1 197 ? -30.77808 3.74967   -63.90941 1.000 16.71295 ? 197 SER   B C   1 
ATOM   3484 O  O   . SER   B 1 197 ? -29.94718 4.57391   -64.31859 1.000 15.52107 ? 197 SER   B O   1 
ATOM   3485 C  CB  . SER   B 1 197 ? -30.87642 1.49747   -64.97166 1.000 14.04761 ? 197 SER   B CB  1 
ATOM   3486 O  OG  . SER   B 1 197 ? -30.34795 0.18381   -64.97196 1.000 13.51913 ? 197 SER   B OG  1 
ATOM   3487 N  N   . ALA   B 1 198 ? -32.04079 4.08441   -63.60967 1.000 14.08840 ? 198 ALA   B N   1 
ATOM   3488 C  CA  . ALA   B 1 198 ? -32.56241 5.43198   -63.82032 1.000 14.82783 ? 198 ALA   B CA  1 
ATOM   3489 C  C   . ALA   B 1 198 ? -31.94610 6.45172   -62.87614 1.000 15.55299 ? 198 ALA   B C   1 
ATOM   3490 O  O   . ALA   B 1 198 ? -31.74416 7.61243   -63.26272 1.000 14.37719 ? 198 ALA   B O   1 
ATOM   3491 C  CB  . ALA   B 1 198 ? -34.08668 5.42903   -63.65563 1.000 16.20151 ? 198 ALA   B CB  1 
ATOM   3492 N  N   . ILE   B 1 199 ? -31.68265 6.05636   -61.62795 1.000 14.60728 ? 199 ILE   B N   1 
ATOM   3493 C  CA  . ILE   B 1 199 ? -31.12734 6.96266   -60.62423 1.000 14.99011 ? 199 ILE   B CA  1 
ATOM   3494 C  C   . ILE   B 1 199 ? -29.60482 6.87700   -60.51469 1.000 12.24836 ? 199 ILE   B C   1 
ATOM   3495 O  O   . ILE   B 1 199 ? -29.01192 7.66933   -59.77263 1.000 12.53453 ? 199 ILE   B O   1 
ATOM   3496 C  CB  . ILE   B 1 199 ? -31.74600 6.70329   -59.23483 1.000 13.81845 ? 199 ILE   B CB  1 
ATOM   3497 C  CG1 . ILE   B 1 199 ? -31.26456 5.35179   -58.68279 1.000 11.52712 ? 199 ILE   B CG1 1 
ATOM   3498 C  CG2 . ILE   B 1 199 ? -33.28152 6.74036   -59.30745 1.000 13.59020 ? 199 ILE   B CG2 1 
ATOM   3499 C  CD1 . ILE   B 1 199 ? -31.54758 5.15275   -57.17260 1.000 12.19131 ? 199 ILE   B CD1 1 
ATOM   3500 N  N   . HIS   B 1 200 ? -28.95493 5.96194   -61.24102 1.000 11.53905 ? 200 HIS   B N   1 
ATOM   3501 C  CA  . HIS   B 1 200 ? -27.60590 5.53305   -60.86333 1.000 11.32593 ? 200 HIS   B CA  1 
ATOM   3502 C  C   . HIS   B 1 200 ? -26.54684 6.63636   -60.99160 1.000 11.38278 ? 200 HIS   B C   1 
ATOM   3503 O  O   . HIS   B 1 200 ? -25.46572 6.48780   -60.41576 1.000 10.28187 ? 200 HIS   B O   1 
ATOM   3504 C  CB  . HIS   B 1 200 ? -27.17048 4.32205   -61.69298 1.000 11.34470 ? 200 HIS   B CB  1 
ATOM   3505 C  CG  . HIS   B 1 200 ? -26.50082 4.69434   -62.97530 1.000 13.30669 ? 200 HIS   B CG  1 
ATOM   3506 N  ND1 . HIS   B 1 200 ? -27.20458 5.03900   -64.10777 1.000 13.10573 ? 200 HIS   B ND1 1 
ATOM   3507 C  CD2 . HIS   B 1 200 ? -25.18944 4.81924   -63.29354 1.000 11.95068 ? 200 HIS   B CD2 1 
ATOM   3508 C  CE1 . HIS   B 1 200 ? -26.35626 5.34283   -65.07391 1.000 12.72521 ? 200 HIS   B CE1 1 
ATOM   3509 N  NE2 . HIS   B 1 200 ? -25.13076 5.22123   -64.60420 1.000 13.41575 ? 200 HIS   B NE2 1 
ATOM   3510 N  N   . ASP   B 1 201 ? -26.82178 7.73586   -61.71157 1.000 12.17321 ? 201 ASP   B N   1 
ATOM   3511 C  CA  . ASP   B 1 201 ? -25.86935 8.84833   -61.78868 1.000 13.63232 ? 201 ASP   B CA  1 
ATOM   3512 C  C   . ASP   B 1 201 ? -26.49896 10.19799  -61.41811 1.000 12.67338 ? 201 ASP   B C   1 
ATOM   3513 O  O   . ASP   B 1 201 ? -25.93686 11.24790  -61.75498 1.000 15.06679 ? 201 ASP   B O   1 
ATOM   3514 C  CB  . ASP   B 1 201 ? -25.24930 8.94288   -63.19155 1.000 10.85939 ? 201 ASP   B CB  1 
ATOM   3515 C  CG  . ASP   B 1 201 ? -23.99640 8.07184   -63.37062 1.000 12.67743 ? 201 ASP   B CG  1 
ATOM   3516 O  OD1 . ASP   B 1 201 ? -23.28876 7.76247   -62.37988 1.000 11.85580 ? 201 ASP   B OD1 1 
ATOM   3517 O  OD2 . ASP   B 1 201 ? -23.71804 7.70750   -64.53682 1.000 8.89340  ? 201 ASP   B OD2 1 
ATOM   3518 N  N   . VAL   B 1 202 ? -27.63177 10.20759  -60.70775 1.000 12.50657 ? 202 VAL   B N   1 
ATOM   3519 C  CA  . VAL   B 1 202 ? -28.40394 11.44002  -60.56243 1.000 15.01403 ? 202 VAL   B CA  1 
ATOM   3520 C  C   . VAL   B 1 202 ? -27.63863 12.48563  -59.74800 1.000 14.47649 ? 202 VAL   B C   1 
ATOM   3521 O  O   . VAL   B 1 202 ? -26.96564 12.17066  -58.75430 1.000 15.05786 ? 202 VAL   B O   1 
ATOM   3522 C  CB  . VAL   B 1 202 ? -29.78243 11.15783  -59.93934 1.000 12.61741 ? 202 VAL   B CB  1 
ATOM   3523 C  CG1 . VAL   B 1 202 ? -29.65788 10.66371  -58.48195 1.000 10.93743 ? 202 VAL   B CG1 1 
ATOM   3524 C  CG2 . VAL   B 1 202 ? -30.64645 12.41390  -60.00869 1.000 14.98628 ? 202 VAL   B CG2 1 
ATOM   3525 N  N   . ASP   B 1 203 ? -27.76029 13.74887  -60.17235 1.000 11.72858 ? 203 ASP   B N   1 
ATOM   3526 C  CA  . ASP   B 1 203 ? -27.08106 14.88474  -59.55426 1.000 13.76262 ? 203 ASP   B CA  1 
ATOM   3527 C  C   . ASP   B 1 203 ? -25.55917 14.75511  -59.65719 1.000 12.98744 ? 203 ASP   B C   1 
ATOM   3528 O  O   . ASP   B 1 203 ? -24.82694 15.20519  -58.76975 1.000 15.56332 ? 203 ASP   B O   1 
ATOM   3529 C  CB  . ASP   B 1 203 ? -27.51816 15.07014  -58.09865 1.000 13.99152 ? 203 ASP   B CB  1 
ATOM   3530 C  CG  . ASP   B 1 203 ? -27.23194 16.47603  -57.58206 1.000 18.00423 ? 203 ASP   B CG  1 
ATOM   3531 O  OD1 . ASP   B 1 203 ? -27.35383 17.43569  -58.37599 1.000 17.43501 ? 203 ASP   B OD1 1 
ATOM   3532 O  OD2 . ASP   B 1 203 ? -26.86525 16.61435  -56.40186 1.000 14.63894 ? 203 ASP   B OD2 1 
ATOM   3533 N  N   . HIS   B 1 204 ? -25.08307 14.12774  -60.73295 1.000 14.83675 ? 204 HIS   B N   1 
ATOM   3534 C  CA  . HIS   B 1 204 ? -23.64442 13.99948  -60.96669 1.000 15.73822 ? 204 HIS   B CA  1 
ATOM   3535 C  C   . HIS   B 1 204 ? -23.08406 15.38035  -61.27834 1.000 16.64577 ? 204 HIS   B C   1 
ATOM   3536 O  O   . HIS   B 1 204 ? -23.62222 16.07255  -62.14913 1.000 14.97228 ? 204 HIS   B O   1 
ATOM   3537 C  CB  . HIS   B 1 204 ? -23.35543 13.04118  -62.13481 1.000 10.20513 ? 204 HIS   B CB  1 
ATOM   3538 C  CG  . HIS   B 1 204 ? -21.96800 12.46217  -62.13822 1.000 13.01012 ? 204 HIS   B CG  1 
ATOM   3539 N  ND1 . HIS   B 1 204 ? -20.82869 13.22972  -62.27302 1.000 12.57514 ? 204 HIS   B ND1 1 
ATOM   3540 C  CD2 . HIS   B 1 204 ? -21.54169 11.17492  -62.06387 1.000 12.12998 ? 204 HIS   B CD2 1 
ATOM   3541 C  CE1 . HIS   B 1 204 ? -19.75933 12.44704  -62.25540 1.000 13.24490 ? 204 HIS   B CE1 1 
ATOM   3542 N  NE2 . HIS   B 1 204 ? -20.16531 11.19059  -62.14070 1.000 14.49334 ? 204 HIS   B NE2 1 
ATOM   3543 N  N   . PRO   B 1 205 ? -22.03475 15.82306  -60.57980 1.000 15.46425 ? 205 PRO   B N   1 
ATOM   3544 C  CA  . PRO   B 1 205 ? -21.43082 17.13406  -60.87186 1.000 17.19837 ? 205 PRO   B CA  1 
ATOM   3545 C  C   . PRO   B 1 205 ? -20.44972 17.13933  -62.03479 1.000 20.17695 ? 205 PRO   B C   1 
ATOM   3546 O  O   . PRO   B 1 205 ? -19.96378 18.21765  -62.39296 1.000 16.09245 ? 205 PRO   B O   1 
ATOM   3547 C  CB  . PRO   B 1 205 ? -20.70368 17.47340  -59.56315 1.000 13.53869 ? 205 PRO   B CB  1 
ATOM   3548 C  CG  . PRO   B 1 205 ? -20.24374 16.11877  -59.05719 1.000 17.97321 ? 205 PRO   B CG  1 
ATOM   3549 C  CD  . PRO   B 1 205 ? -21.36530 15.13947  -59.45828 1.000 12.53930 ? 205 PRO   B CD  1 
ATOM   3550 N  N   . GLY   B 1 206 ? -20.12747 15.98960  -62.62797 1.000 14.95592 ? 206 GLY   B N   1 
ATOM   3551 C  CA  . GLY   B 1 206 ? -19.23069 15.96290  -63.76360 1.000 13.55382 ? 206 GLY   B CA  1 
ATOM   3552 C  C   . GLY   B 1 206 ? -17.76687 15.85501  -63.40682 1.000 18.04941 ? 206 GLY   B C   1 
ATOM   3553 O  O   . GLY   B 1 206 ? -16.90854 16.08405  -64.27003 1.000 15.19503 ? 206 GLY   B O   1 
ATOM   3554 N  N   . VAL   B 1 207 ? -17.45582 15.50921  -62.16497 1.000 13.90621 ? 207 VAL   B N   1 
ATOM   3555 C  CA  . VAL   B 1 207 ? -16.08957 15.28141  -61.72606 1.000 17.72188 ? 207 VAL   B CA  1 
ATOM   3556 C  C   . VAL   B 1 207 ? -16.06137 13.93351  -61.02247 1.000 16.15585 ? 207 VAL   B C   1 
ATOM   3557 O  O   . VAL   B 1 207 ? -17.08918 13.42385  -60.56625 1.000 17.35118 ? 207 VAL   B O   1 
ATOM   3558 C  CB  . VAL   B 1 207 ? -15.58087 16.39883  -60.79495 1.000 21.01192 ? 207 VAL   B CB  1 
ATOM   3559 C  CG1 . VAL   B 1 207 ? -15.44762 17.71546  -61.57378 1.000 21.01875 ? 207 VAL   B CG1 1 
ATOM   3560 C  CG2 . VAL   B 1 207 ? -16.53086 16.55387  -59.60973 1.000 17.49117 ? 207 VAL   B CG2 1 
ATOM   3561 N  N   . SER   B 1 208 ? -14.86851 13.35752  -60.94948 1.000 13.24510 ? 208 SER   B N   1 
ATOM   3562 C  CA  . SER   B 1 208 ? -14.68289 12.01080  -60.44104 1.000 15.36220 ? 208 SER   B CA  1 
ATOM   3563 C  C   . SER   B 1 208 ? -14.68306 11.99378  -58.91611 1.000 16.07231 ? 208 SER   B C   1 
ATOM   3564 O  O   . SER   B 1 208 ? -14.50227 13.02387  -58.25827 1.000 16.82874 ? 208 SER   B O   1 
ATOM   3565 C  CB  . SER   B 1 208 ? -13.35807 11.44096  -60.93087 1.000 15.94367 ? 208 SER   B CB  1 
ATOM   3566 O  OG  . SER   B 1 208 ? -12.29326 12.20689  -60.38014 1.000 15.98257 ? 208 SER   B OG  1 
ATOM   3567 N  N   . ASN   B 1 209 ? -14.83785 10.78410  -58.36175 1.000 13.38321 ? 209 ASN   B N   1 
ATOM   3568 C  CA  . ASN   B 1 209 ? -14.68702 10.59320  -56.92245 1.000 14.89610 ? 209 ASN   B CA  1 
ATOM   3569 C  C   . ASN   B 1 209 ? -13.32786 11.09980  -56.44703 1.000 17.10635 ? 209 ASN   B C   1 
ATOM   3570 O  O   . ASN   B 1 209 ? -13.22535 11.76425  -55.41241 1.000 16.14619 ? 209 ASN   B O   1 
ATOM   3571 C  CB  . ASN   B 1 209 ? -14.85488 9.10700   -56.56856 1.000 13.58490 ? 209 ASN   B CB  1 
ATOM   3572 C  CG  . ASN   B 1 209 ? -16.32638 8.67518   -56.45826 1.000 13.37954 ? 209 ASN   B CG  1 
ATOM   3573 O  OD1 . ASN   B 1 209 ? -17.18494 9.45330   -56.04874 1.000 12.46946 ? 209 ASN   B OD1 1 
ATOM   3574 N  ND2 . ASN   B 1 209 ? -16.60909 7.42005   -56.81096 1.000 15.38988 ? 209 ASN   B ND2 1 
ATOM   3575 N  N   . GLN   B 1 210 ? -12.27427 10.81015  -57.20416 1.000 20.67332 ? 210 GLN   B N   1 
ATOM   3576 C  CA  . GLN   B 1 210 ? -10.93864 11.23617  -56.79981 1.000 19.26385 ? 210 GLN   B CA  1 
ATOM   3577 C  C   . GLN   B 1 210 ? -10.82186 12.75976  -56.75755 1.000 18.42341 ? 210 GLN   B C   1 
ATOM   3578 O  O   . GLN   B 1 210 ? -10.18909 13.31360  -55.84684 1.000 25.04290 ? 210 GLN   B O   1 
ATOM   3579 C  CB  . GLN   B 1 210 ? -9.89723  10.61889  -57.73950 1.000 22.15703 ? 210 GLN   B CB  1 
ATOM   3580 C  CG  . GLN   B 1 210 ? -8.49523  10.57053  -57.13949 1.000 27.03654 ? 210 GLN   B CG  1 
ATOM   3581 C  CD  . GLN   B 1 210 ? -8.44951  9.80118   -55.82313 1.000 29.11355 ? 210 GLN   B CD  1 
ATOM   3582 O  OE1 . GLN   B 1 210 ? -8.56625  8.57413   -55.80779 1.000 33.17583 ? 210 GLN   B OE1 1 
ATOM   3583 N  NE2 . GLN   B 1 210 ? -8.28245  10.52208  -54.71257 1.000 28.49675 ? 210 GLN   B NE2 1 
ATOM   3584 N  N   . PHE   B 1 211 ? -11.42241 13.45904  -57.72255 1.000 15.15275 ? 211 PHE   B N   1 
ATOM   3585 C  CA  . PHE   B 1 211 ? -11.45633 14.92127  -57.66872 1.000 17.40294 ? 211 PHE   B CA  1 
ATOM   3586 C  C   . PHE   B 1 211 ? -12.17330 15.40366  -56.41684 1.000 23.56527 ? 211 PHE   B C   1 
ATOM   3587 O  O   . PHE   B 1 211 ? -11.69957 16.31930  -55.72733 1.000 20.37967 ? 211 PHE   B O   1 
ATOM   3588 C  CB  . PHE   B 1 211 ? -12.13936 15.47458  -58.92575 1.000 17.50237 ? 211 PHE   B CB  1 
ATOM   3589 C  CG  . PHE   B 1 211 ? -12.21306 16.98876  -58.98551 1.000 21.86105 ? 211 PHE   B CG  1 
ATOM   3590 C  CD1 . PHE   B 1 211 ? -13.28727 17.67608  -58.42187 1.000 22.46309 ? 211 PHE   B CD1 1 
ATOM   3591 C  CD2 . PHE   B 1 211 ? -11.22918 17.71975  -59.64331 1.000 24.53097 ? 211 PHE   B CD2 1 
ATOM   3592 C  CE1 . PHE   B 1 211 ? -13.36720 19.06947  -58.49555 1.000 28.97624 ? 211 PHE   B CE1 1 
ATOM   3593 C  CE2 . PHE   B 1 211 ? -11.29544 19.10427  -59.71718 1.000 25.82762 ? 211 PHE   B CE2 1 
ATOM   3594 C  CZ  . PHE   B 1 211 ? -12.36083 19.78615  -59.14522 1.000 26.23351 ? 211 PHE   B CZ  1 
ATOM   3595 N  N   . LEU   B 1 212 ? -13.32753 14.80134  -56.11293 1.000 18.23792 ? 212 LEU   B N   1 
ATOM   3596 C  CA  . LEU   B 1 212 ? -14.09125 15.19781  -54.93544 1.000 19.54776 ? 212 LEU   B CA  1 
ATOM   3597 C  C   . LEU   B 1 212 ? -13.29311 14.96892  -53.65957 1.000 18.76509 ? 212 LEU   B C   1 
ATOM   3598 O  O   . LEU   B 1 212 ? -13.36759 15.76691  -52.71953 1.000 21.63204 ? 212 LEU   B O   1 
ATOM   3599 C  CB  . LEU   B 1 212 ? -15.42049 14.42962  -54.90123 1.000 17.51231 ? 212 LEU   B CB  1 
ATOM   3600 C  CG  . LEU   B 1 212 ? -16.33200 14.80994  -56.06881 1.000 14.50415 ? 212 LEU   B CG  1 
ATOM   3601 C  CD1 . LEU   B 1 212 ? -17.49979 13.83597  -56.16578 1.000 17.48603 ? 212 LEU   B CD1 1 
ATOM   3602 C  CD2 . LEU   B 1 212 ? -16.85505 16.22597  -55.90297 1.000 15.41073 ? 212 LEU   B CD2 1 
ATOM   3603 N  N   . ILE   B 1 213 ? -12.51386 13.89224  -53.61454 1.000 19.78015 ? 213 ILE   B N   1 
ATOM   3604 C  CA  . ILE   B 1 213 ? -11.67036 13.63821  -52.45250 1.000 21.42336 ? 213 ILE   B CA  1 
ATOM   3605 C  C   . ILE   B 1 213 ? -10.56161 14.68433  -52.35102 1.000 24.66869 ? 213 ILE   B C   1 
ATOM   3606 O  O   . ILE   B 1 213 ? -10.33302 15.25485  -51.27722 1.000 25.31840 ? 213 ILE   B O   1 
ATOM   3607 C  CB  . ILE   B 1 213 ? -11.11328 12.20897  -52.51619 1.000 16.79218 ? 213 ILE   B CB  1 
ATOM   3608 C  CG1 . ILE   B 1 213 ? -12.24689 11.19837  -52.31755 1.000 17.37799 ? 213 ILE   B CG1 1 
ATOM   3609 C  CG2 . ILE   B 1 213 ? -10.05283 12.00902  -51.45967 1.000 19.71829 ? 213 ILE   B CG2 1 
ATOM   3610 C  CD1 . ILE   B 1 213 ? -11.85989 9.77537   -52.64101 1.000 16.63850 ? 213 ILE   B CD1 1 
ATOM   3611 N  N   . ASN   B 1 214 ? -9.90440  14.99796  -53.48001 1.000 26.11895 ? 214 ASN   B N   1 
ATOM   3612 C  CA  . ASN   B 1 214 ? -8.72410  15.86937  -53.48196 1.000 28.88326 ? 214 ASN   B CA  1 
ATOM   3613 C  C   . ASN   B 1 214 ? -9.06976  17.32760  -53.22931 1.000 28.53296 ? 214 ASN   B C   1 
ATOM   3614 O  O   . ASN   B 1 214 ? -8.21450  18.09413  -52.76647 1.000 31.82547 ? 214 ASN   B O   1 
ATOM   3615 C  CB  . ASN   B 1 214 ? -7.98296  15.77379  -54.81640 1.000 24.90571 ? 214 ASN   B CB  1 
ATOM   3616 C  CG  . ASN   B 1 214 ? -7.41847  14.40427  -55.07049 1.000 21.81096 ? 214 ASN   B CG  1 
ATOM   3617 O  OD1 . ASN   B 1 214 ? -7.29902  13.58577  -54.15682 1.000 25.42078 ? 214 ASN   B OD1 1 
ATOM   3618 N  ND2 . ASN   B 1 214 ? -7.05410  14.14281  -56.32399 1.000 26.96110 ? 214 ASN   B ND2 1 
ATOM   3619 N  N   . THR   B 1 215 ? -10.28310 17.74372  -53.55524 1.000 23.88187 ? 215 THR   B N   1 
ATOM   3620 C  CA  . THR   B 1 215 ? -10.69215 19.11706  -53.33365 1.000 29.22969 ? 215 THR   B CA  1 
ATOM   3621 C  C   . THR   B 1 215 ? -11.37953 19.31760  -51.98157 1.000 25.86159 ? 215 THR   B C   1 
ATOM   3622 O  O   . THR   B 1 215 ? -11.92524 20.39778  -51.73548 1.000 29.99677 ? 215 THR   B O   1 
ATOM   3623 C  CB  . THR   B 1 215 ? -11.59683 19.58587  -54.48395 1.000 30.97145 ? 215 THR   B CB  1 
ATOM   3624 O  OG1 . THR   B 1 215 ? -12.75879 18.74930  -54.57379 1.000 24.30435 ? 215 THR   B OG1 1 
ATOM   3625 C  CG2 . THR   B 1 215 ? -10.83189 19.52363  -55.82025 1.000 27.04799 ? 215 THR   B CG2 1 
ATOM   3626 N  N   . ASN   B 1 216 ? -11.36062 18.31006  -51.10767 1.000 30.00398 ? 216 ASN   B N   1 
ATOM   3627 C  CA  . ASN   B 1 216 ? -11.98444 18.39502  -49.78311 1.000 30.70642 ? 216 ASN   B CA  1 
ATOM   3628 C  C   . ASN   B 1 216 ? -13.43891 18.84590  -49.89977 1.000 26.21093 ? 216 ASN   B C   1 
ATOM   3629 O  O   . ASN   B 1 216 ? -13.88226 19.81427  -49.27568 1.000 23.56405 ? 216 ASN   B O   1 
ATOM   3630 C  CB  . ASN   B 1 216 ? -11.16640 19.31504  -48.87712 1.000 31.74995 ? 216 ASN   B CB  1 
ATOM   3631 C  CG  . ASN   B 1 216 ? -9.68614  18.97792  -48.92413 1.000 36.27843 ? 216 ASN   B CG  1 
ATOM   3632 O  OD1 . ASN   B 1 216 ? -9.29729  17.82282  -48.72380 1.000 38.11909 ? 216 ASN   B OD1 1 
ATOM   3633 N  ND2 . ASN   B 1 216 ? -8.85687  19.97091  -49.24065 1.000 40.24882 ? 216 ASN   B ND2 1 
ATOM   3634 N  N   . SER   B 1 217 ? -14.17292 18.14325  -50.75846 1.000 23.12841 ? 217 SER   B N   1 
ATOM   3635 C  CA  . SER   B 1 217 ? -15.54148 18.48627  -51.08687 1.000 19.45099 ? 217 SER   B CA  1 
ATOM   3636 C  C   . SER   B 1 217 ? -16.48450 18.12778  -49.94737 1.000 19.27436 ? 217 SER   B C   1 
ATOM   3637 O  O   . SER   B 1 217 ? -16.21563 17.24290  -49.13264 1.000 20.11642 ? 217 SER   B O   1 
ATOM   3638 C  CB  . SER   B 1 217 ? -15.98794 17.74854  -52.35008 1.000 20.55991 ? 217 SER   B CB  1 
ATOM   3639 O  OG  . SER   B 1 217 ? -15.84519 16.34476  -52.17094 1.000 18.71613 ? 217 SER   B OG  1 
ATOM   3640 N  N   . GLU   B 1 218 ? -17.62582 18.81233  -49.93136 1.000 16.84122 ? 218 GLU   B N   1 
ATOM   3641 C  CA  . GLU   B 1 218 ? -18.70002 18.44266  -49.02149 1.000 23.87610 ? 218 GLU   B CA  1 
ATOM   3642 C  C   . GLU   B 1 218 ? -19.10553 16.98158  -49.20980 1.000 20.39307 ? 218 GLU   B C   1 
ATOM   3643 O  O   . GLU   B 1 218 ? -19.32242 16.26319  -48.22799 1.000 20.61506 ? 218 GLU   B O   1 
ATOM   3644 C  CB  . GLU   B 1 218 ? -19.89437 19.37784  -49.23470 1.000 27.18859 ? 218 GLU   B CB  1 
ATOM   3645 C  CG  . GLU   B 1 218 ? -20.54905 19.85921  -47.94756 1.000 36.91457 ? 218 GLU   B CG  1 
ATOM   3646 C  CD  . GLU   B 1 218 ? -19.52901 20.34746  -46.93221 1.000 42.68433 ? 218 GLU   B CD  1 
ATOM   3647 O  OE1 . GLU   B 1 218 ? -18.60730 21.09800  -47.32736 1.000 46.86726 ? 218 GLU   B OE1 1 
ATOM   3648 O  OE2 . GLU   B 1 218 ? -19.63093 19.96412  -45.74418 1.000 41.66929 ? 218 GLU   B OE2 1 
ATOM   3649 N  N   . LEU   B 1 219 ? -19.17180 16.51530  -50.46281 1.000 16.45394 ? 219 LEU   B N   1 
ATOM   3650 C  CA  . LEU   B 1 219 ? -19.59011 15.13870  -50.74082 1.000 18.33448 ? 219 LEU   B CA  1 
ATOM   3651 C  C   . LEU   B 1 219 ? -18.62844 14.11662  -50.14338 1.000 14.75667 ? 219 LEU   B C   1 
ATOM   3652 O  O   . LEU   B 1 219 ? -19.05767 13.14800  -49.50526 1.000 11.68115 ? 219 LEU   B O   1 
ATOM   3653 C  CB  . LEU   B 1 219 ? -19.72126 14.91966  -52.25021 1.000 16.87338 ? 219 LEU   B CB  1 
ATOM   3654 C  CG  . LEU   B 1 219 ? -21.07493 15.30668  -52.84522 1.000 22.23529 ? 219 LEU   B CG  1 
ATOM   3655 C  CD1 . LEU   B 1 219 ? -21.07151 15.11050  -54.34062 1.000 25.77351 ? 219 LEU   B CD1 1 
ATOM   3656 C  CD2 . LEU   B 1 219 ? -22.18452 14.48727  -52.21722 1.000 19.82225 ? 219 LEU   B CD2 1 
ATOM   3657 N  N   . ALA   B 1 220 ? -17.32196 14.29174  -50.37067 1.000 13.02511 ? 220 ALA   B N   1 
ATOM   3658 C  CA  . ALA   B 1 220 ? -16.34804 13.34584  -49.83429 1.000 13.79368 ? 220 ALA   B CA  1 
ATOM   3659 C  C   . ALA   B 1 220 ? -16.31063 13.39295  -48.31121 1.000 16.32777 ? 220 ALA   B C   1 
ATOM   3660 O  O   . ALA   B 1 220 ? -16.12738 12.35809  -47.65179 1.000 13.09306 ? 220 ALA   B O   1 
ATOM   3661 C  CB  . ALA   B 1 220 ? -14.96053 13.63695  -50.41080 1.000 15.56867 ? 220 ALA   B CB  1 
ATOM   3662 N  N   . LEU   B 1 221 ? -16.50375 14.58144  -47.74011 1.000 14.95923 ? 221 LEU   B N   1 
ATOM   3663 C  CA  . LEU   B 1 221 ? -16.58429 14.70746  -46.28985 1.000 13.99830 ? 221 LEU   B CA  1 
ATOM   3664 C  C   . LEU   B 1 221 ? -17.82261 14.00012  -45.74168 1.000 15.70881 ? 221 LEU   B C   1 
ATOM   3665 O  O   . LEU   B 1 221 ? -17.75452 13.33105  -44.69962 1.000 15.76164 ? 221 LEU   B O   1 
ATOM   3666 C  CB  . LEU   B 1 221 ? -16.56761 16.19241  -45.93348 1.000 15.20367 ? 221 LEU   B CB  1 
ATOM   3667 C  CG  . LEU   B 1 221 ? -16.50175 16.74552  -44.52655 1.000 27.41729 ? 221 LEU   B CG  1 
ATOM   3668 C  CD1 . LEU   B 1 221 ? -15.43930 16.04343  -43.71059 1.000 21.55827 ? 221 LEU   B CD1 1 
ATOM   3669 C  CD2 . LEU   B 1 221 ? -16.19522 18.26050  -44.64160 1.000 27.41284 ? 221 LEU   B CD2 1 
ATOM   3670 N  N   . MET   B 1 222 ? -18.95515 14.09805  -46.45134 1.000 14.95465 ? 222 MET   B N   1 
ATOM   3671 C  CA  . MET   B 1 222 ? -20.15190 13.37359  -46.02849 1.000 14.02120 ? 222 MET   B CA  1 
ATOM   3672 C  C   . MET   B 1 222 ? -19.93942 11.85675  -46.05776 1.000 12.38198 ? 222 MET   B C   1 
ATOM   3673 O  O   . MET   B 1 222 ? -20.34347 11.14192  -45.12674 1.000 11.55327 ? 222 MET   B O   1 
ATOM   3674 C  CB  . MET   B 1 222 ? -21.33121 13.75227  -46.92110 1.000 13.16853 ? 222 MET   B CB  1 
ATOM   3675 C  CG  . MET   B 1 222 ? -22.65320 13.08589  -46.50091 1.000 15.49363 ? 222 MET   B CG  1 
ATOM   3676 S  SD  . MET   B 1 222 ? -23.32589 13.85293  -45.01144 1.000 20.33337 ? 222 MET   B SD  1 
ATOM   3677 C  CE  . MET   B 1 222 ? -23.93415 15.43347  -45.65411 1.000 19.60259 ? 222 MET   B CE  1 
ATOM   3678 N  N   . TYR   B 1 223 ? -19.31276 11.34627  -47.11392 1.000 11.50848 ? 223 TYR   B N   1 
ATOM   3679 C  CA  . TYR   B 1 223 ? -19.29045 9.91123   -47.38783 1.000 14.39687 ? 223 TYR   B CA  1 
ATOM   3680 C  C   . TYR   B 1 223 ? -17.94078 9.25281   -47.12421 1.000 14.30878 ? 223 TYR   B C   1 
ATOM   3681 O  O   . TYR   B 1 223 ? -17.71748 8.11641   -47.57206 1.000 11.44246 ? 223 TYR   B O   1 
ATOM   3682 C  CB  . TYR   B 1 223 ? -19.74056 9.66580   -48.82866 1.000 12.21526 ? 223 TYR   B CB  1 
ATOM   3683 C  CG  . TYR   B 1 223 ? -21.22806 9.93125   -48.98652 1.000 13.23063 ? 223 TYR   B CG  1 
ATOM   3684 C  CD1 . TYR   B 1 223 ? -22.15128 9.15926   -48.29438 1.000 9.34111  ? 223 TYR   B CD1 1 
ATOM   3685 C  CD2 . TYR   B 1 223 ? -21.70951 10.95394  -49.80537 1.000 12.49810 ? 223 TYR   B CD2 1 
ATOM   3686 C  CE1 . TYR   B 1 223 ? -23.50786 9.38952   -48.40673 1.000 13.14110 ? 223 TYR   B CE1 1 
ATOM   3687 C  CE2 . TYR   B 1 223 ? -23.08690 11.17903  -49.94807 1.000 11.01815 ? 223 TYR   B CE2 1 
ATOM   3688 C  CZ  . TYR   B 1 223 ? -23.97310 10.39705  -49.23623 1.000 12.77565 ? 223 TYR   B CZ  1 
ATOM   3689 O  OH  . TYR   B 1 223 ? -25.33141 10.58732  -49.33633 1.000 11.46428 ? 223 TYR   B OH  1 
ATOM   3690 N  N   . ASN   B 1 224 ? -17.03813 9.93052   -46.41320 1.000 11.64088 ? 224 ASN   B N   1 
ATOM   3691 C  CA  . ASN   B 1 224 ? -15.79668 9.31367   -45.92417 1.000 10.16988 ? 224 ASN   B CA  1 
ATOM   3692 C  C   . ASN   B 1 224 ? -15.00153 8.66192   -47.04845 1.000 11.31999 ? 224 ASN   B C   1 
ATOM   3693 O  O   . ASN   B 1 224 ? -14.46329 7.56360   -46.90317 1.000 10.02316 ? 224 ASN   B O   1 
ATOM   3694 C  CB  . ASN   B 1 224 ? -16.09859 8.31302   -44.81377 1.000 11.13197 ? 224 ASN   B CB  1 
ATOM   3695 C  CG  . ASN   B 1 224 ? -16.74125 8.97068   -43.63263 1.000 11.10204 ? 224 ASN   B CG  1 
ATOM   3696 O  OD1 . ASN   B 1 224 ? -16.18008 9.91387   -43.06298 1.000 13.81128 ? 224 ASN   B OD1 1 
ATOM   3697 N  ND2 . ASN   B 1 224 ? -17.95017 8.52461   -43.27304 1.000 10.13312 ? 224 ASN   B ND2 1 
ATOM   3698 N  N   . ASP   B 1 225 ? -14.95152 9.34427   -48.19097 1.000 11.75759 ? 225 ASP   B N   1 
ATOM   3699 C  CA  . ASP   B 1 225 ? -14.13154 8.99016   -49.35238 1.000 16.00758 ? 225 ASP   B CA  1 
ATOM   3700 C  C   . ASP   B 1 225 ? -14.52053 7.65401   -50.00177 1.000 12.99190 ? 225 ASP   B C   1 
ATOM   3701 O  O   . ASP   B 1 225 ? -13.85750 7.22510   -50.94491 1.000 15.28323 ? 225 ASP   B O   1 
ATOM   3702 C  CB  . ASP   B 1 225 ? -12.62817 8.97214   -49.00763 1.000 14.69696 ? 225 ASP   B CB  1 
ATOM   3703 C  CG  . ASP   B 1 225 ? -12.11214 10.31880  -48.48882 1.000 14.44180 ? 225 ASP   B CG  1 
ATOM   3704 O  OD1 . ASP   B 1 225 ? -12.78737 11.35724  -48.67410 1.000 13.93058 ? 225 ASP   B OD1 1 
ATOM   3705 O  OD2 . ASP   B 1 225 ? -11.00546 10.34589  -47.90349 1.000 14.26530 ? 225 ASP   B OD2 1 
ATOM   3706 N  N   . SER   B 1 226 ? -15.57715 6.97814   -49.55381 1.000 9.28918  ? 226 SER   B N   1 
ATOM   3707 C  CA  . SER   B 1 226 ? -15.92944 5.66759   -50.11217 1.000 13.41778 ? 226 SER   B CA  1 
ATOM   3708 C  C   . SER   B 1 226 ? -17.15905 5.77692   -51.01267 1.000 14.23097 ? 226 SER   B C   1 
ATOM   3709 O  O   . SER   B 1 226 ? -18.23747 6.17079   -50.54828 1.000 11.22250 ? 226 SER   B O   1 
ATOM   3710 C  CB  . SER   B 1 226 ? -16.17472 4.64358   -49.00324 1.000 15.06081 ? 226 SER   B CB  1 
ATOM   3711 O  OG  . SER   B 1 226 ? -15.08828 4.64740   -48.08719 1.000 31.39356 ? 226 SER   B OG  1 
ATOM   3712 N  N   . SER   B 1 227 ? -16.99443 5.41677   -52.28879 1.000 11.84477 ? 227 SER   B N   1 
ATOM   3713 C  CA  . SER   B 1 227 ? -18.07265 5.46534   -53.29227 1.000 13.67515 ? 227 SER   B CA  1 
ATOM   3714 C  C   . SER   B 1 227 ? -18.90498 6.73542   -53.14195 1.000 12.16586 ? 227 SER   B C   1 
ATOM   3715 O  O   . SER   B 1 227 ? -20.13104 6.70733   -53.00844 1.000 11.49862 ? 227 SER   B O   1 
ATOM   3716 C  CB  . SER   B 1 227 ? -18.95142 4.21481   -53.21540 1.000 13.79425 ? 227 SER   B CB  1 
ATOM   3717 O  OG  . SER   B 1 227 ? -18.21460 3.05476   -53.59872 1.000 12.09575 ? 227 SER   B OG  1 
ATOM   3718 N  N   . VAL   B 1 228 ? -18.20232 7.86910   -53.14107 1.000 10.98547 ? 228 VAL   B N   1 
ATOM   3719 C  CA  . VAL   B 1 228 ? -18.82303 9.13407   -52.75323 1.000 11.64533 ? 228 VAL   B CA  1 
ATOM   3720 C  C   . VAL   B 1 228 ? -19.97380 9.47851   -53.68923 1.000 10.13678 ? 228 VAL   B C   1 
ATOM   3721 O  O   . VAL   B 1 228 ? -21.09120 9.76986   -53.24621 1.000 11.10929 ? 228 VAL   B O   1 
ATOM   3722 C  CB  . VAL   B 1 228 ? -17.75338 10.24307  -52.71183 1.000 12.92292 ? 228 VAL   B CB  1 
ATOM   3723 C  CG1 . VAL   B 1 228 ? -18.37935 11.61517  -52.55078 1.000 11.50829 ? 228 VAL   B CG1 1 
ATOM   3724 C  CG2 . VAL   B 1 228 ? -16.78580 9.95864   -51.57367 1.000 9.76305  ? 228 VAL   B CG2 1 
ATOM   3725 N  N   . LEU   B 1 229 ? -19.71777 9.45523   -54.99936 1.000 12.42224 ? 229 LEU   B N   1 
ATOM   3726 C  CA  . LEU   B 1 229 ? -20.76124 9.79352   -55.96439 1.000 12.10592 ? 229 LEU   B CA  1 
ATOM   3727 C  C   . LEU   B 1 229 ? -21.93164 8.82097   -55.87557 1.000 12.27267 ? 229 LEU   B C   1 
ATOM   3728 O  O   . LEU   B 1 229 ? -23.10318 9.23215   -55.87398 1.000 12.85525 ? 229 LEU   B O   1 
ATOM   3729 C  CB  . LEU   B 1 229 ? -20.17616 9.78902   -57.37883 1.000 12.96054 ? 229 LEU   B CB  1 
ATOM   3730 C  CG  . LEU   B 1 229 ? -19.31535 10.99360  -57.76263 1.000 12.96910 ? 229 LEU   B CG  1 
ATOM   3731 C  CD1 . LEU   B 1 229 ? -18.60276 10.73440  -59.08379 1.000 14.94883 ? 229 LEU   B CD1 1 
ATOM   3732 C  CD2 . LEU   B 1 229 ? -20.18701 12.23926  -57.86347 1.000 12.97842 ? 229 LEU   B CD2 1 
ATOM   3733 N  N   . GLU   B 1 230 ? -21.62057 7.51949   -55.81691 1.000 11.32003 ? 230 GLU   B N   1 
ATOM   3734 C  CA  . GLU   B 1 230 ? -22.63545 6.47226   -55.89371 1.000 11.63498 ? 230 GLU   B CA  1 
ATOM   3735 C  C   . GLU   B 1 230 ? -23.54709 6.48713   -54.67373 1.000 12.51380 ? 230 GLU   B C   1 
ATOM   3736 O  O   . GLU   B 1 230 ? -24.75650 6.26123   -54.79880 1.000 10.97648 ? 230 GLU   B O   1 
ATOM   3737 C  CB  . GLU   B 1 230 ? -21.95879 5.10719   -56.05327 1.000 10.85098 ? 230 GLU   B CB  1 
ATOM   3738 C  CG  . GLU   B 1 230 ? -21.28503 4.89787   -57.44181 1.000 12.85747 ? 230 GLU   B CG  1 
ATOM   3739 C  CD  . GLU   B 1 230 ? -19.93992 5.63338   -57.61922 1.000 13.76293 ? 230 GLU   B CD  1 
ATOM   3740 O  OE1 . GLU   B 1 230 ? -19.26795 5.95507   -56.61845 1.000 12.72585 ? 230 GLU   B OE1 1 
ATOM   3741 O  OE2 . GLU   B 1 230 ? -19.55307 5.88204   -58.77927 1.000 14.28337 ? 230 GLU   B OE2 1 
ATOM   3742 N  N   . ASN   B 1 231 ? -22.98467 6.75082   -53.48974 1.000 11.98723 ? 231 ASN   B N   1 
ATOM   3743 C  CA  . ASN   B 1 231 ? -23.81388 6.92840   -52.30368 1.000 11.59946 ? 231 ASN   B CA  1 
ATOM   3744 C  C   . ASN   B 1 231 ? -24.71679 8.13942   -52.45671 1.000 12.89805 ? 231 ASN   B C   1 
ATOM   3745 O  O   . ASN   B 1 231 ? -25.88346 8.10437   -52.05343 1.000 10.24109 ? 231 ASN   B O   1 
ATOM   3746 C  CB  . ASN   B 1 231 ? -22.94683 7.08774   -51.05637 1.000 10.97393 ? 231 ASN   B CB  1 
ATOM   3747 C  CG  . ASN   B 1 231 ? -22.60054 5.77190   -50.42263 1.000 14.13816 ? 231 ASN   B CG  1 
ATOM   3748 O  OD1 . ASN   B 1 231 ? -23.48214 5.07096   -49.92117 1.000 17.10909 ? 231 ASN   B OD1 1 
ATOM   3749 N  ND2 . ASN   B 1 231 ? -21.30962 5.43051   -50.41166 1.000 11.98576 ? 231 ASN   B ND2 1 
ATOM   3750 N  N   . HIS   B 1 232 ? -24.19118 9.21801   -53.05104 1.000 14.07211 ? 232 HIS   B N   1 
ATOM   3751 C  CA  . HIS   B 1 232 ? -24.99700 10.41296  -53.27380 1.000 12.56722 ? 232 HIS   B CA  1 
ATOM   3752 C  C   . HIS   B 1 232 ? -26.11985 10.15835  -54.28039 1.000 12.96490 ? 232 HIS   B C   1 
ATOM   3753 O  O   . HIS   B 1 232 ? -27.26286 10.59401  -54.06252 1.000 14.75978 ? 232 HIS   B O   1 
ATOM   3754 C  CB  . HIS   B 1 232 ? -24.10244 11.56658  -53.73381 1.000 11.12132 ? 232 HIS   B CB  1 
ATOM   3755 C  CG  . HIS   B 1 232 ? -24.84378 12.85707  -53.93459 1.000 15.71450 ? 232 HIS   B CG  1 
ATOM   3756 N  ND1 . HIS   B 1 232 ? -25.55019 13.47429  -52.92354 1.000 13.27623 ? 232 HIS   B ND1 1 
ATOM   3757 C  CD2 . HIS   B 1 232 ? -24.98752 13.64648  -55.02749 1.000 14.03137 ? 232 HIS   B CD2 1 
ATOM   3758 C  CE1 . HIS   B 1 232 ? -26.09341 14.58663  -53.38212 1.000 14.54121 ? 232 HIS   B CE1 1 
ATOM   3759 N  NE2 . HIS   B 1 232 ? -25.77374 14.71024  -54.65835 1.000 16.54260 ? 232 HIS   B NE2 1 
ATOM   3760 N  N   . HIS   B 1 233 ? -25.82586 9.45434   -55.38282 1.000 10.90477 ? 233 HIS   B N   1 
ATOM   3761 C  CA  . HIS   B 1 233 ? -26.86494 9.15669   -56.37550 1.000 10.31231 ? 233 HIS   B CA  1 
ATOM   3762 C  C   . HIS   B 1 233 ? -28.03768 8.41650   -55.73404 1.000 14.12141 ? 233 HIS   B C   1 
ATOM   3763 O  O   . HIS   B 1 233 ? -29.21045 8.73512   -55.98754 1.000 11.04765 ? 233 HIS   B O   1 
ATOM   3764 C  CB  . HIS   B 1 233 ? -26.30957 8.31205   -57.53636 1.000 10.54417 ? 233 HIS   B CB  1 
ATOM   3765 C  CG  . HIS   B 1 233 ? -25.11068 8.89013   -58.22510 1.000 11.67521 ? 233 HIS   B CG  1 
ATOM   3766 N  ND1 . HIS   B 1 233 ? -25.02559 10.21334  -58.60591 1.000 11.35353 ? 233 HIS   B ND1 1 
ATOM   3767 C  CD2 . HIS   B 1 233 ? -23.95856 8.30621   -58.63455 1.000 12.25685 ? 233 HIS   B CD2 1 
ATOM   3768 C  CE1 . HIS   B 1 233 ? -23.86495 10.42204  -59.20575 1.000 11.62116 ? 233 HIS   B CE1 1 
ATOM   3769 N  NE2 . HIS   B 1 233 ? -23.19859 9.28090   -59.23503 1.000 14.22800 ? 233 HIS   B NE2 1 
ATOM   3770 N  N   . LEU   B 1 234 ? -27.72321 7.38529   -54.93501 1.000 11.23884 ? 234 LEU   B N   1 
ATOM   3771 C  CA  . LEU   B 1 234 ? -28.73392 6.64914   -54.18143 1.000 13.62073 ? 234 LEU   B CA  1 
ATOM   3772 C  C   . LEU   B 1 234 ? -29.54753 7.57414   -53.28455 1.000 13.25978 ? 234 LEU   B C   1 
ATOM   3773 O  O   . LEU   B 1 234 ? -30.78425 7.55991   -53.31697 1.000 13.38945 ? 234 LEU   B O   1 
ATOM   3774 C  CB  . LEU   B 1 234 ? -28.05683 5.55236   -53.34800 1.000 10.30521 ? 234 LEU   B CB  1 
ATOM   3775 C  CG  . LEU   B 1 234 ? -27.66896 4.31557   -54.16412 1.000 10.67367 ? 234 LEU   B CG  1 
ATOM   3776 C  CD1 . LEU   B 1 234 ? -26.68503 3.42897   -53.39670 1.000 10.34557 ? 234 LEU   B CD1 1 
ATOM   3777 C  CD2 . LEU   B 1 234 ? -28.94121 3.52356   -54.53465 1.000 10.59638 ? 234 LEU   B CD2 1 
ATOM   3778 N  N   . ALA   B 1 235 ? -28.86436 8.38312   -52.46803 1.000 14.01020 ? 235 ALA   B N   1 
ATOM   3779 C  CA  . ALA   B 1 235 ? -29.56436 9.21155   -51.49157 1.000 13.92247 ? 235 ALA   B CA  1 
ATOM   3780 C  C   . ALA   B 1 235 ? -30.51381 10.19897  -52.17137 1.000 15.54300 ? 235 ALA   B C   1 
ATOM   3781 O  O   . ALA   B 1 235 ? -31.62710 10.42395  -51.68716 1.000 13.94150 ? 235 ALA   B O   1 
ATOM   3782 C  CB  . ALA   B 1 235 ? -28.55428 9.94521   -50.60520 1.000 13.91471 ? 235 ALA   B CB  1 
ATOM   3783 N  N   . VAL   B 1 236 ? -30.10297 10.77630  -53.30793 1.000 12.69078 ? 236 VAL   B N   1 
ATOM   3784 C  CA  . VAL   B 1 236 ? -30.97713 11.68798  -54.04779 1.000 13.05867 ? 236 VAL   B CA  1 
ATOM   3785 C  C   . VAL   B 1 236 ? -32.13409 10.92102  -54.69078 1.000 15.49527 ? 236 VAL   B C   1 
ATOM   3786 O  O   . VAL   B 1 236 ? -33.30896 11.30017  -54.55614 1.000 15.46386 ? 236 VAL   B O   1 
ATOM   3787 C  CB  . VAL   B 1 236 ? -30.16591 12.48440  -55.09634 1.000 14.08253 ? 236 VAL   B CB  1 
ATOM   3788 C  CG1 . VAL   B 1 236 ? -31.08387 13.33192  -55.96794 1.000 14.18297 ? 236 VAL   B CG1 1 
ATOM   3789 C  CG2 . VAL   B 1 236 ? -29.10743 13.38804  -54.40304 1.000 12.97571 ? 236 VAL   B CG2 1 
ATOM   3790 N  N   . GLY   B 1 237 ? -31.82215 9.82233   -55.38063 1.000 13.53607 ? 237 GLY   B N   1 
ATOM   3791 C  CA  . GLY   B 1 237 ? -32.86522 9.04169   -56.03502 1.000 13.79930 ? 237 GLY   B CA  1 
ATOM   3792 C  C   . GLY   B 1 237 ? -33.97128 8.61311   -55.08894 1.000 19.40965 ? 237 GLY   B C   1 
ATOM   3793 O  O   . GLY   B 1 237 ? -35.15389 8.65841   -55.44427 1.000 20.29670 ? 237 GLY   B O   1 
ATOM   3794 N  N   . PHE   B 1 238 ? -33.60726 8.19595   -53.86870 1.000 15.66656 ? 238 PHE   B N   1 
ATOM   3795 C  CA  . PHE   B 1 238 ? -34.62153 7.80250   -52.88898 1.000 16.28162 ? 238 PHE   B CA  1 
ATOM   3796 C  C   . PHE   B 1 238 ? -35.29568 9.01565   -52.26051 1.000 15.96991 ? 238 PHE   B C   1 
ATOM   3797 O  O   . PHE   B 1 238 ? -36.50243 8.98833   -52.01482 1.000 19.60507 ? 238 PHE   B O   1 
ATOM   3798 C  CB  . PHE   B 1 238 ? -34.01329 6.92579   -51.78947 1.000 14.39009 ? 238 PHE   B CB  1 
ATOM   3799 C  CG  . PHE   B 1 238 ? -33.68488 5.52201   -52.23029 1.000 16.48672 ? 238 PHE   B CG  1 
ATOM   3800 C  CD1 . PHE   B 1 238 ? -34.68395 4.61137   -52.52910 1.000 17.91439 ? 238 PHE   B CD1 1 
ATOM   3801 C  CD2 . PHE   B 1 238 ? -32.37619 5.10694   -52.31002 1.000 16.65432 ? 238 PHE   B CD2 1 
ATOM   3802 C  CE1 . PHE   B 1 238 ? -34.38048 3.31621   -52.92342 1.000 18.90427 ? 238 PHE   B CE1 1 
ATOM   3803 C  CE2 . PHE   B 1 238 ? -32.05677 3.80298   -52.70679 1.000 19.53893 ? 238 PHE   B CE2 1 
ATOM   3804 C  CZ  . PHE   B 1 238 ? -33.05427 2.91111   -53.00979 1.000 17.19705 ? 238 PHE   B CZ  1 
ATOM   3805 N  N   . LYS   B 1 239 ? -34.53537 10.08579  -51.99850 1.000 17.63054 ? 239 LYS   B N   1 
ATOM   3806 C  CA  . LYS   B 1 239 ? -35.09839 11.28029  -51.36229 1.000 22.42743 ? 239 LYS   B CA  1 
ATOM   3807 C  C   . LYS   B 1 239 ? -36.22667 11.89334  -52.18845 1.000 20.42649 ? 239 LYS   B C   1 
ATOM   3808 O  O   . LYS   B 1 239 ? -37.24430 12.32802  -51.63291 1.000 21.27765 ? 239 LYS   B O   1 
ATOM   3809 C  CB  . LYS   B 1 239 ? -33.99603 12.31295  -51.12403 1.000 24.10111 ? 239 LYS   B CB  1 
ATOM   3810 C  CG  . LYS   B 1 239 ? -34.48000 13.66597  -50.63858 1.000 28.33593 ? 239 LYS   B CG  1 
ATOM   3811 C  CD  . LYS   B 1 239 ? -34.99884 13.57309  -49.22212 1.000 38.13426 ? 239 LYS   B CD  1 
ATOM   3812 C  CE  . LYS   B 1 239 ? -34.96409 14.92104  -48.52096 1.000 30.94047 ? 239 LYS   B CE  1 
ATOM   3813 N  NZ  . LYS   B 1 239 ? -35.35468 14.74714  -47.09922 1.000 33.93755 ? 239 LYS   B NZ  1 
ATOM   3814 N  N   . LEU   B 1 240 ? -36.06549 11.93830  -53.51486 1.000 15.97736 ? 240 LEU   B N   1 
ATOM   3815 C  CA  . LEU   B 1 240 ? -37.08743 12.49403  -54.40148 1.000 20.14176 ? 240 LEU   B CA  1 
ATOM   3816 C  C   . LEU   B 1 240 ? -38.40762 11.72584  -54.35464 1.000 24.18455 ? 240 LEU   B C   1 
ATOM   3817 O  O   . LEU   B 1 240 ? -39.44154 12.27545  -54.75592 1.000 19.66790 ? 240 LEU   B O   1 
ATOM   3818 C  CB  . LEU   B 1 240 ? -36.55844 12.53327  -55.83995 1.000 16.26305 ? 240 LEU   B CB  1 
ATOM   3819 C  CG  . LEU   B 1 240 ? -35.35740 13.48350  -55.95182 1.000 21.58565 ? 240 LEU   B CG  1 
ATOM   3820 C  CD1 . LEU   B 1 240 ? -34.63782 13.41043  -57.31484 1.000 17.59445 ? 240 LEU   B CD1 1 
ATOM   3821 C  CD2 . LEU   B 1 240 ? -35.80047 14.91970  -55.63736 1.000 23.98794 ? 240 LEU   B CD2 1 
ATOM   3822 N  N   . LEU   B 1 241 ? -38.39814 10.46392  -53.90773 1.000 22.44539 ? 241 LEU   B N   1 
ATOM   3823 C  CA  . LEU   B 1 241 ? -39.65435 9.73315   -53.74082 1.000 24.57264 ? 241 LEU   B CA  1 
ATOM   3824 C  C   . LEU   B 1 241 ? -40.57929 10.40221  -52.73497 1.000 24.30062 ? 241 LEU   B C   1 
ATOM   3825 O  O   . LEU   B 1 241 ? -41.79392 10.16353  -52.76718 1.000 26.58714 ? 241 LEU   B O   1 
ATOM   3826 C  CB  . LEU   B 1 241 ? -39.39064 8.29930   -53.28841 1.000 23.34578 ? 241 LEU   B CB  1 
ATOM   3827 C  CG  . LEU   B 1 241 ? -38.78675 7.33885   -54.31040 1.000 24.50882 ? 241 LEU   B CG  1 
ATOM   3828 C  CD1 . LEU   B 1 241 ? -38.34188 6.08418   -53.58948 1.000 20.38012 ? 241 LEU   B CD1 1 
ATOM   3829 C  CD2 . LEU   B 1 241 ? -39.77926 7.00026   -55.42052 1.000 21.58611 ? 241 LEU   B CD2 1 
ATOM   3830 N  N   . GLN   B 1 242 ? -40.03088 11.22658  -51.84847 1.000 20.81595 ? 242 GLN   B N   1 
ATOM   3831 C  CA  . GLN   B 1 242 ? -40.78118 11.89292  -50.79490 1.000 23.82596 ? 242 GLN   B CA  1 
ATOM   3832 C  C   . GLN   B 1 242 ? -41.38249 13.23128  -51.22201 1.000 30.39034 ? 242 GLN   B C   1 
ATOM   3833 O  O   . GLN   B 1 242 ? -42.06946 13.86854  -50.41201 1.000 26.85786 ? 242 GLN   B O   1 
ATOM   3834 C  CB  . GLN   B 1 242 ? -39.87733 12.08020  -49.57339 1.000 24.76160 ? 242 GLN   B CB  1 
ATOM   3835 C  CG  . GLN   B 1 242 ? -39.58402 10.75896  -48.84774 1.000 24.33243 ? 242 GLN   B CG  1 
ATOM   3836 C  CD  . GLN   B 1 242 ? -38.42062 10.83938  -47.88314 1.000 37.59316 ? 242 GLN   B CD  1 
ATOM   3837 O  OE1 . GLN   B 1 242 ? -37.92861 11.92591  -47.56087 1.000 40.73331 ? 242 GLN   B OE1 1 
ATOM   3838 N  NE2 . GLN   B 1 242 ? -37.95409 9.67531   -47.43000 1.000 36.98144 ? 242 GLN   B NE2 1 
ATOM   3839 N  N   . GLU   B 1 243 ? -41.14885 13.67402  -52.45732 1.000 27.58497 ? 243 GLU   B N   1 
ATOM   3840 C  CA  . GLU   B 1 243 ? -41.80174 14.87916  -52.95457 1.000 28.55852 ? 243 GLU   B CA  1 
ATOM   3841 C  C   . GLU   B 1 243 ? -43.26780 14.58412  -53.27247 1.000 27.35573 ? 243 GLU   B C   1 
ATOM   3842 O  O   . GLU   B 1 243 ? -43.67999 13.42650  -53.39966 1.000 28.57279 ? 243 GLU   B O   1 
ATOM   3843 C  CB  . GLU   B 1 243 ? -41.07245 15.41476  -54.19017 1.000 25.96812 ? 243 GLU   B CB  1 
ATOM   3844 C  CG  . GLU   B 1 243 ? -39.61615 15.81897  -53.92530 1.000 30.35279 ? 243 GLU   B CG  1 
ATOM   3845 C  CD  . GLU   B 1 243 ? -39.49428 17.03485  -53.01691 1.000 33.49326 ? 243 GLU   B CD  1 
ATOM   3846 O  OE1 . GLU   B 1 243 ? -40.39517 17.90040  -53.03494 1.000 44.01582 ? 243 GLU   B OE1 1 
ATOM   3847 O  OE2 . GLU   B 1 243 ? -38.49614 17.12952  -52.27553 1.000 41.27095 ? 243 GLU   B OE2 1 
ATOM   3848 N  N   . GLU   B 1 244 ? -44.06475 15.64513  -53.40100 1.000 29.66921 ? 244 GLU   B N   1 
ATOM   3849 C  CA  . GLU   B 1 244 ? -45.51115 15.45686  -53.51174 1.000 29.83486 ? 244 GLU   B CA  1 
ATOM   3850 C  C   . GLU   B 1 244 ? -45.88020 14.65334  -54.75586 1.000 32.04129 ? 244 GLU   B C   1 
ATOM   3851 O  O   . GLU   B 1 244 ? -45.47264 14.98344  -55.87449 1.000 31.48313 ? 244 GLU   B O   1 
ATOM   3852 C  CB  . GLU   B 1 244 ? -46.23740 16.79995  -53.52416 1.000 37.48648 ? 244 GLU   B CB  1 
ATOM   3853 C  CG  . GLU   B 1 244 ? -47.71345 16.66144  -53.92640 1.000 45.99688 ? 244 GLU   B CG  1 
ATOM   3854 C  CD  . GLU   B 1 244 ? -48.62390 17.64011  -53.20208 1.000 58.56448 ? 244 GLU   B CD  1 
ATOM   3855 O  OE1 . GLU   B 1 244 ? -49.50449 17.18410  -52.43590 1.000 64.27304 ? 244 GLU   B OE1 1 
ATOM   3856 O  OE2 . GLU   B 1 244 ? -48.45208 18.86408  -53.39256 1.000 64.58293 ? 244 GLU   B OE2 1 
ATOM   3857 N  N   . ASN   B 1 245 ? -46.65870 13.58915  -54.54756 1.000 28.25375 ? 245 ASN   B N   1 
ATOM   3858 C  CA  . ASN   B 1 245 ? -47.12469 12.72004  -55.62753 1.000 30.60881 ? 245 ASN   B CA  1 
ATOM   3859 C  C   . ASN   B 1 245 ? -45.95472 12.09673  -56.38847 1.000 31.38759 ? 245 ASN   B C   1 
ATOM   3860 O  O   . ASN   B 1 245 ? -46.03401 11.85805  -57.59484 1.000 31.35330 ? 245 ASN   B O   1 
ATOM   3861 C  CB  . ASN   B 1 245 ? -48.06208 13.47032  -56.58341 1.000 29.50972 ? 245 ASN   B CB  1 
ATOM   3862 C  CG  . ASN   B 1 245 ? -48.84324 12.52989  -57.50691 1.000 35.82078 ? 245 ASN   B CG  1 
ATOM   3863 O  OD1 . ASN   B 1 245 ? -49.02636 11.34287  -57.20891 1.000 35.36047 ? 245 ASN   B OD1 1 
ATOM   3864 N  ND2 . ASN   B 1 245 ? -49.29425 13.05842  -58.63892 1.000 36.58034 ? 245 ASN   B ND2 1 
ATOM   3865 N  N   . CYS   B 1 246 ? -44.85646 11.80366  -55.67789 1.000 31.92510 ? 246 CYS   B N   1 
ATOM   3866 C  CA  . CYS   B 1 246 ? -43.70298 11.17099  -56.31078 1.000 29.66939 ? 246 CYS   B CA  1 
ATOM   3867 C  C   . CYS   B 1 246 ? -43.42526 9.74363   -55.85728 1.000 26.90711 ? 246 CYS   B C   1 
ATOM   3868 O  O   . CYS   B 1 246 ? -42.52380 9.10900   -56.41958 1.000 22.69038 ? 246 CYS   B O   1 
ATOM   3869 C  CB  . CYS   B 1 246 ? -42.43504 12.01058  -56.08590 1.000 24.76155 ? 246 CYS   B CB  1 
ATOM   3870 S  SG  . CYS   B 1 246 ? -42.41249 13.55051  -57.04886 1.000 27.09744 ? 246 CYS   B SG  1 
ATOM   3871 N  N   . ASP   B 1 247 ? -44.15545 9.21529   -54.87456 1.000 26.35138 ? 247 ASP   B N   1 
ATOM   3872 C  CA  . ASP   B 1 247 ? -43.83600 7.89412   -54.32559 1.000 24.54319 ? 247 ASP   B CA  1 
ATOM   3873 C  C   . ASP   B 1 247 ? -44.42421 6.81543   -55.22580 1.000 30.59592 ? 247 ASP   B C   1 
ATOM   3874 O  O   . ASP   B 1 247 ? -45.52356 6.29448   -54.99320 1.000 27.28285 ? 247 ASP   B O   1 
ATOM   3875 C  CB  . ASP   B 1 247 ? -44.34220 7.75557   -52.89258 1.000 28.89784 ? 247 ASP   B CB  1 
ATOM   3876 C  CG  . ASP   B 1 247 ? -43.88017 6.45931   -52.23772 1.000 30.01078 ? 247 ASP   B CG  1 
ATOM   3877 O  OD1 . ASP   B 1 247 ? -43.22830 5.63887   -52.92483 1.000 27.79343 ? 247 ASP   B OD1 1 
ATOM   3878 O  OD2 . ASP   B 1 247 ? -44.17355 6.25664   -51.03891 1.000 32.02891 ? 247 ASP   B OD2 1 
ATOM   3879 N  N   . ILE   B 1 248 ? -43.65225 6.42941   -56.24361 1.000 22.98482 ? 248 ILE   B N   1 
ATOM   3880 C  CA  . ILE   B 1 248 ? -44.10832 5.39564   -57.15724 1.000 25.11298 ? 248 ILE   B CA  1 
ATOM   3881 C  C   . ILE   B 1 248 ? -44.18877 4.02593   -56.50011 1.000 25.20685 ? 248 ILE   B C   1 
ATOM   3882 O  O   . ILE   B 1 248 ? -44.72674 3.09231   -57.10408 1.000 24.55572 ? 248 ILE   B O   1 
ATOM   3883 C  CB  . ILE   B 1 248 ? -43.19910 5.35166   -58.40116 1.000 27.41321 ? 248 ILE   B CB  1 
ATOM   3884 C  CG1 . ILE   B 1 248 ? -41.76795 4.98009   -58.01564 1.000 26.91834 ? 248 ILE   B CG1 1 
ATOM   3885 C  CG2 . ILE   B 1 248 ? -43.21480 6.70139   -59.12970 1.000 26.52139 ? 248 ILE   B CG2 1 
ATOM   3886 C  CD1 . ILE   B 1 248 ? -40.89133 4.73687   -59.21487 1.000 22.05872 ? 248 ILE   B CD1 1 
ATOM   3887 N  N   . PHE   B 1 249 ? -43.68120 3.87873   -55.27568 1.000 24.71802 ? 249 PHE   B N   1 
ATOM   3888 C  CA  . PHE   B 1 249 ? -43.72422 2.60390   -54.57083 1.000 27.05677 ? 249 PHE   B CA  1 
ATOM   3889 C  C   . PHE   B 1 249 ? -44.77561 2.59261   -53.46596 1.000 26.54247 ? 249 PHE   B C   1 
ATOM   3890 O  O   . PHE   B 1 249 ? -44.72287 1.74191   -52.57256 1.000 26.32615 ? 249 PHE   B O   1 
ATOM   3891 C  CB  . PHE   B 1 249 ? -42.34686 2.26672   -54.00182 1.000 25.22087 ? 249 PHE   B CB  1 
ATOM   3892 C  CG  . PHE   B 1 249 ? -41.24419 2.28751   -55.02961 1.000 27.07564 ? 249 PHE   B CG  1 
ATOM   3893 C  CD1 . PHE   B 1 249 ? -41.28134 1.43543   -56.13102 1.000 26.59596 ? 249 PHE   B CD1 1 
ATOM   3894 C  CD2 . PHE   B 1 249 ? -40.16205 3.14922   -54.89117 1.000 27.76105 ? 249 PHE   B CD2 1 
ATOM   3895 C  CE1 . PHE   B 1 249 ? -40.26525 1.45179   -57.07708 1.000 28.45512 ? 249 PHE   B CE1 1 
ATOM   3896 C  CE2 . PHE   B 1 249 ? -39.13230 3.15801   -55.83679 1.000 24.40103 ? 249 PHE   B CE2 1 
ATOM   3897 C  CZ  . PHE   B 1 249 ? -39.18726 2.31615   -56.92460 1.000 22.23302 ? 249 PHE   B CZ  1 
ATOM   3898 N  N   . GLN   B 1 250 ? -45.74000 3.51361   -53.52595 1.000 27.18140 ? 250 GLN   B N   1 
ATOM   3899 C  CA  . GLN   B 1 250 ? -46.70205 3.68336   -52.43595 1.000 31.87996 ? 250 GLN   B CA  1 
ATOM   3900 C  C   . GLN   B 1 250 ? -47.57895 2.45151   -52.24197 1.000 28.34911 ? 250 GLN   B C   1 
ATOM   3901 O  O   . GLN   B 1 250 ? -48.05301 2.20466   -51.13129 1.000 30.43652 ? 250 GLN   B O   1 
ATOM   3902 C  CB  . GLN   B 1 250 ? -47.57785 4.90487   -52.70077 1.000 25.90227 ? 250 GLN   B CB  1 
ATOM   3903 C  CG  . GLN   B 1 250 ? -48.40160 4.77787   -53.97475 1.000 31.35073 ? 250 GLN   B CG  1 
ATOM   3904 C  CD  . GLN   B 1 250 ? -48.84298 6.12551   -54.51922 1.000 40.70380 ? 250 GLN   B CD  1 
ATOM   3905 O  OE1 . GLN   B 1 250 ? -50.03375 6.36771   -54.71204 1.000 38.88826 ? 250 GLN   B OE1 1 
ATOM   3906 N  NE2 . GLN   B 1 250 ? -47.87962 7.01131   -54.76858 1.000 33.44112 ? 250 GLN   B NE2 1 
ATOM   3907 N  N   . ASN   B 1 251 ? -47.79647 1.66292   -53.29479 1.000 25.51908 ? 251 ASN   B N   1 
ATOM   3908 C  CA  . ASN   B 1 251 ? -48.64604 0.48396   -53.20927 1.000 32.14956 ? 251 ASN   B CA  1 
ATOM   3909 C  C   . ASN   B 1 251 ? -47.84094 -0.81174  -53.19600 1.000 34.33637 ? 251 ASN   B C   1 
ATOM   3910 O  O   . ASN   B 1 251 ? -48.40076 -1.88807  -53.43141 1.000 30.13032 ? 251 ASN   B O   1 
ATOM   3911 C  CB  . ASN   B 1 251 ? -49.67387 0.48042   -54.34415 1.000 31.71935 ? 251 ASN   B CB  1 
ATOM   3912 C  CG  . ASN   B 1 251 ? -50.66551 1.63004   -54.23377 1.000 27.95011 ? 251 ASN   B CG  1 
ATOM   3913 O  OD1 . ASN   B 1 251 ? -51.06086 2.02792   -53.13464 1.000 32.41284 ? 251 ASN   B OD1 1 
ATOM   3914 N  ND2 . ASN   B 1 251 ? -51.06175 2.17605   -55.37053 1.000 32.76519 ? 251 ASN   B ND2 1 
ATOM   3915 N  N   . LEU   B 1 252 ? -46.53826 -0.73105  -52.92672 1.000 30.88150 ? 252 LEU   B N   1 
ATOM   3916 C  CA  . LEU   B 1 252 ? -45.76595 -1.91371  -52.57357 1.000 35.29053 ? 252 LEU   B CA  1 
ATOM   3917 C  C   . LEU   B 1 252 ? -45.94713 -2.20205  -51.09258 1.000 29.87867 ? 252 LEU   B C   1 
ATOM   3918 O  O   . LEU   B 1 252 ? -46.12070 -1.28842  -50.28345 1.000 31.93715 ? 252 LEU   B O   1 
ATOM   3919 C  CB  . LEU   B 1 252 ? -44.26972 -1.72598  -52.87358 1.000 29.96929 ? 252 LEU   B CB  1 
ATOM   3920 C  CG  . LEU   B 1 252 ? -43.71242 -2.02989  -54.26967 1.000 27.59247 ? 252 LEU   B CG  1 
ATOM   3921 C  CD1 . LEU   B 1 252 ? -44.20549 -1.00749  -55.27994 1.000 27.20321 ? 252 LEU   B CD1 1 
ATOM   3922 C  CD2 . LEU   B 1 252 ? -42.17122 -2.08707  -54.25254 1.000 25.79902 ? 252 LEU   B CD2 1 
ATOM   3923 N  N   . THR   B 1 253 ? -45.89453 -3.48201  -50.73528 1.000 31.67711 ? 253 THR   B N   1 
ATOM   3924 C  CA  . THR   B 1 253 ? -45.86992 -3.82255  -49.31903 1.000 31.99508 ? 253 THR   B CA  1 
ATOM   3925 C  C   . THR   B 1 253 ? -44.57453 -3.32434  -48.68964 1.000 35.04746 ? 253 THR   B C   1 
ATOM   3926 O  O   . THR   B 1 253 ? -43.61809 -2.95583  -49.37665 1.000 29.39268 ? 253 THR   B O   1 
ATOM   3927 C  CB  . THR   B 1 253 ? -45.99489 -5.32953  -49.11562 1.000 31.75057 ? 253 THR   B CB  1 
ATOM   3928 O  OG1 . THR   B 1 253 ? -44.70817 -5.94156  -49.30402 1.000 33.60382 ? 253 THR   B OG1 1 
ATOM   3929 C  CG2 . THR   B 1 253 ? -46.98264 -5.91704  -50.10579 1.000 28.99699 ? 253 THR   B CG2 1 
ATOM   3930 N  N   . LYS   B 1 254 ? -44.53939 -3.32105  -47.35859 1.000 35.52862 ? 254 LYS   B N   1 
ATOM   3931 C  CA  . LYS   B 1 254 ? -43.36608 -2.77046  -46.68936 1.000 39.54036 ? 254 LYS   B CA  1 
ATOM   3932 C  C   . LYS   B 1 254 ? -42.14630 -3.65966  -46.89352 1.000 31.43274 ? 254 LYS   B C   1 
ATOM   3933 O  O   . LYS   B 1 254 ? -41.01978 -3.16005  -46.99855 1.000 28.69426 ? 254 LYS   B O   1 
ATOM   3934 C  CB  . LYS   B 1 254 ? -43.63752 -2.57093  -45.20291 1.000 43.24881 ? 254 LYS   B CB  1 
ATOM   3935 C  CG  . LYS   B 1 254 ? -42.72525 -1.51754  -44.59939 1.000 49.65418 ? 254 LYS   B CG  1 
ATOM   3936 C  CD  . LYS   B 1 254 ? -42.12428 -1.99533  -43.29295 1.000 57.91379 ? 254 LYS   B CD  1 
ATOM   3937 C  CE  . LYS   B 1 254 ? -43.14414 -1.84636  -42.17568 1.000 61.51515 ? 254 LYS   B CE  1 
ATOM   3938 N  NZ  . LYS   B 1 254 ? -42.85848 -2.77019  -41.04187 1.000 60.19792 ? 254 LYS   B NZ  1 
ATOM   3939 N  N   . LYS   B 1 255 ? -42.35146 -4.97685  -46.95871 1.000 31.60167 ? 255 LYS   B N   1 
ATOM   3940 C  CA  . LYS   B 1 255 ? -41.23209 -5.87497  -47.20219 1.000 32.26781 ? 255 LYS   B CA  1 
ATOM   3941 C  C   . LYS   B 1 255 ? -40.81410 -5.87903  -48.66764 1.000 31.31649 ? 255 LYS   B C   1 
ATOM   3942 O  O   . LYS   B 1 255 ? -39.63831 -6.10975  -48.96995 1.000 28.28300 ? 255 LYS   B O   1 
ATOM   3943 C  CB  . LYS   B 1 255 ? -41.57227 -7.28445  -46.72607 1.000 32.18033 ? 255 LYS   B CB  1 
ATOM   3944 C  CG  . LYS   B 1 255 ? -41.54929 -7.39954  -45.20339 1.000 39.31276 ? 255 LYS   B CG  1 
ATOM   3945 C  CD  . LYS   B 1 255 ? -42.08773 -8.73909  -44.70430 1.000 44.33969 ? 255 LYS   B CD  1 
ATOM   3946 C  CE  . LYS   B 1 255 ? -42.22301 -8.75565  -43.17753 1.000 39.79136 ? 255 LYS   B CE  1 
ATOM   3947 N  NZ  . LYS   B 1 255 ? -42.66157 -10.09723 -42.69176 1.000 38.75789 ? 255 LYS   B NZ  1 
ATOM   3948 N  N   . GLN   B 1 256 ? -41.74666 -5.64320  -49.58797 1.000 27.45819 ? 256 GLN   B N   1 
ATOM   3949 C  CA  . GLN   B 1 256 ? -41.35038 -5.41716  -50.97211 1.000 27.85171 ? 256 GLN   B CA  1 
ATOM   3950 C  C   . GLN   B 1 256 ? -40.47235 -4.17497  -51.08325 1.000 26.34921 ? 256 GLN   B C   1 
ATOM   3951 O  O   . GLN   B 1 256 ? -39.44404 -4.18811  -51.77026 1.000 25.55960 ? 256 GLN   B O   1 
ATOM   3952 C  CB  . GLN   B 1 256 ? -42.58657 -5.27973  -51.85981 1.000 29.46822 ? 256 GLN   B CB  1 
ATOM   3953 C  CG  . GLN   B 1 256 ? -43.29995 -6.57561  -52.16618 1.000 27.52812 ? 256 GLN   B CG  1 
ATOM   3954 C  CD  . GLN   B 1 256 ? -44.42781 -6.36541  -53.14843 1.000 27.11587 ? 256 GLN   B CD  1 
ATOM   3955 O  OE1 . GLN   B 1 256 ? -45.27340 -5.48899  -52.96107 1.000 29.69555 ? 256 GLN   B OE1 1 
ATOM   3956 N  NE2 . GLN   B 1 256 ? -44.43528 -7.14780  -54.21461 1.000 34.61123 ? 256 GLN   B NE2 1 
ATOM   3957 N  N   . ARG   B 1 257 ? -40.87105 -3.08911  -50.40675 1.000 26.44109 ? 257 ARG   B N   1 
ATOM   3958 C  CA  . ARG   B 1 257 ? -40.08531 -1.85827  -50.41463 1.000 25.44979 ? 257 ARG   B CA  1 
ATOM   3959 C  C   . ARG   B 1 257 ? -38.72295 -2.07247  -49.77234 1.000 21.71812 ? 257 ARG   B C   1 
ATOM   3960 O  O   . ARG   B 1 257 ? -37.69806 -1.63026  -50.30636 1.000 23.28846 ? 257 ARG   B O   1 
ATOM   3961 C  CB  . ARG   B 1 257 ? -40.85156 -0.74064  -49.70258 1.000 28.25248 ? 257 ARG   B CB  1 
ATOM   3962 C  CG  . ARG   B 1 257 ? -42.14289 -0.32791  -50.41700 1.000 29.59467 ? 257 ARG   B CG  1 
ATOM   3963 C  CD  . ARG   B 1 257 ? -43.04361 0.54559   -49.53664 1.000 32.51379 ? 257 ARG   B CD  1 
ATOM   3964 N  NE  . ARG   B 1 257 ? -42.37677 1.78715   -49.16239 1.000 39.07409 ? 257 ARG   B NE  1 
ATOM   3965 C  CZ  . ARG   B 1 257 ? -42.64498 2.97017   -49.70198 1.000 40.51814 ? 257 ARG   B CZ  1 
ATOM   3966 N  NH1 . ARG   B 1 257 ? -43.58287 3.08137   -50.62963 1.000 42.47706 ? 257 ARG   B NH1 1 
ATOM   3967 N  NH2 . ARG   B 1 257 ? -41.98264 4.04534   -49.30654 1.000 44.96734 ? 257 ARG   B NH2 1 
ATOM   3968 N  N   . GLN   B 1 258 ? -38.69104 -2.76333  -48.63413 1.000 21.85730 ? 258 GLN   B N   1 
ATOM   3969 C  CA  . GLN   B 1 258 ? -37.42431 -3.12800  -48.00539 1.000 26.19795 ? 258 GLN   B CA  1 
ATOM   3970 C  C   . GLN   B 1 258 ? -36.54077 -3.93344  -48.95875 1.000 26.29186 ? 258 GLN   B C   1 
ATOM   3971 O  O   . GLN   B 1 258 ? -35.33837 -3.66408  -49.08601 1.000 19.59983 ? 258 GLN   B O   1 
ATOM   3972 C  CB  . GLN   B 1 258 ? -37.69284 -3.91730  -46.72126 1.000 27.03391 ? 258 GLN   B CB  1 
ATOM   3973 C  CG  . GLN   B 1 258 ? -36.44313 -4.35477  -45.99568 1.000 29.81749 ? 258 GLN   B CG  1 
ATOM   3974 C  CD  . GLN   B 1 258 ? -36.68819 -5.48791  -45.00013 1.000 41.78510 ? 258 GLN   B CD  1 
ATOM   3975 O  OE1 . GLN   B 1 258 ? -37.83425 -5.83533  -44.68916 1.000 38.47933 ? 258 GLN   B OE1 1 
ATOM   3976 N  NE2 . GLN   B 1 258 ? -35.60153 -6.07012  -44.49823 1.000 39.37636 ? 258 GLN   B NE2 1 
ATOM   3977 N  N   . SER   B 1 259 ? -37.11562 -4.93330  -49.63547 1.000 21.01190 ? 259 SER   B N   1 
ATOM   3978 C  CA  . SER   B 1 259 ? -36.30010 -5.75311  -50.52675 1.000 18.06744 ? 259 SER   B CA  1 
ATOM   3979 C  C   . SER   B 1 259 ? -35.82975 -4.95404  -51.73751 1.000 20.77656 ? 259 SER   B C   1 
ATOM   3980 O  O   . SER   B 1 259 ? -34.67430 -5.08350  -52.16004 1.000 18.08375 ? 259 SER   B O   1 
ATOM   3981 C  CB  . SER   B 1 259 ? -37.06525 -6.99576  -50.97975 1.000 22.56974 ? 259 SER   B CB  1 
ATOM   3982 O  OG  . SER   B 1 259 ? -36.30389 -7.73113  -51.94363 1.000 21.31937 ? 259 SER   B OG  1 
ATOM   3983 N  N   . LEU   B 1 260 ? -36.71324 -4.12899  -52.30413 1.000 19.52508 ? 260 LEU   B N   1 
ATOM   3984 C  CA  . LEU   B 1 260 ? -36.35038 -3.28872  -53.44116 1.000 21.77735 ? 260 LEU   B CA  1 
ATOM   3985 C  C   . LEU   B 1 260 ? -35.25867 -2.28833  -53.06830 1.000 18.82630 ? 260 LEU   B C   1 
ATOM   3986 O  O   . LEU   B 1 260 ? -34.29670 -2.08527  -53.82238 1.000 16.75258 ? 260 LEU   B O   1 
ATOM   3987 C  CB  . LEU   B 1 260 ? -37.59456 -2.56540  -53.94833 1.000 18.72337 ? 260 LEU   B CB  1 
ATOM   3988 C  CG  . LEU   B 1 260 ? -37.43859 -1.55025  -55.06624 1.000 27.88330 ? 260 LEU   B CG  1 
ATOM   3989 C  CD1 . LEU   B 1 260 ? -36.71451 -2.20512  -56.15572 1.000 30.09938 ? 260 LEU   B CD1 1 
ATOM   3990 C  CD2 . LEU   B 1 260 ? -38.78801 -1.14009  -55.56727 1.000 31.22433 ? 260 LEU   B CD2 1 
ATOM   3991 N  N   . ARG   B 1 261 ? -35.40001 -1.64561  -51.90788 1.000 17.22173 ? 261 ARG   B N   1 
ATOM   3992 C  CA  . ARG   B 1 261 ? -34.39837 -0.67770  -51.46391 1.000 18.60663 ? 261 ARG   B CA  1 
ATOM   3993 C  C   . ARG   B 1 261 ? -33.01539 -1.30661  -51.39727 1.000 16.58202 ? 261 ARG   B C   1 
ATOM   3994 O  O   . ARG   B 1 261 ? -32.04353 -0.72830  -51.89213 1.000 14.64307 ? 261 ARG   B O   1 
ATOM   3995 C  CB  . ARG   B 1 261 ? -34.79197 -0.09880  -50.10482 1.000 17.12507 ? 261 ARG   B CB  1 
ATOM   3996 C  CG  . ARG   B 1 261 ? -33.75709 0.81804   -49.49012 1.000 14.96361 ? 261 ARG   B CG  1 
ATOM   3997 C  CD  . ARG   B 1 261 ? -34.35523 1.63789   -48.33395 1.000 15.37985 ? 261 ARG   B CD  1 
ATOM   3998 N  NE  . ARG   B 1 261 ? -33.29949 2.34840   -47.60716 1.000 18.60652 ? 261 ARG   B NE  1 
ATOM   3999 C  CZ  . ARG   B 1 261 ? -32.75794 3.50282   -47.99207 1.000 15.15168 ? 261 ARG   B CZ  1 
ATOM   4000 N  NH1 . ARG   B 1 261 ? -33.19810 4.12330   -49.09548 1.000 14.66561 ? 261 ARG   B NH1 1 
ATOM   4001 N  NH2 . ARG   B 1 261 ? -31.79273 4.05423   -47.25252 1.000 13.07507 ? 261 ARG   B NH2 1 
ATOM   4002 N  N   . LYS   B 1 262 ? -32.91370 -2.50901  -50.82012 1.000 16.50219 ? 262 LYS   B N   1 
ATOM   4003 C  CA  . LYS   B 1 262 ? -31.61095 -3.15346  -50.67327 1.000 19.16827 ? 262 LYS   B CA  1 
ATOM   4004 C  C   . LYS   B 1 262 ? -31.01187 -3.51723  -52.02613 1.000 18.08708 ? 262 LYS   B C   1 
ATOM   4005 O  O   . LYS   B 1 262 ? -29.80322 -3.35457  -52.24742 1.000 15.88233 ? 262 LYS   B O   1 
ATOM   4006 C  CB  . LYS   B 1 262 ? -31.73463 -4.41039  -49.81310 1.000 18.67222 ? 262 LYS   B CB  1 
ATOM   4007 C  CG  . LYS   B 1 262 ? -30.40485 -5.14800  -49.64417 1.000 20.31588 ? 262 LYS   B CG  1 
ATOM   4008 C  CD  . LYS   B 1 262 ? -30.60916 -6.53964  -49.06931 1.000 26.03200 ? 262 LYS   B CD  1 
ATOM   4009 C  CE  . LYS   B 1 262 ? -29.27468 -7.18303  -48.74525 1.000 29.65408 ? 262 LYS   B CE  1 
ATOM   4010 N  NZ  . LYS   B 1 262 ? -28.57655 -6.36462  -47.70673 1.000 29.35107 ? 262 LYS   B NZ  1 
ATOM   4011 N  N   . MET   B 1 263 ? -31.83696 -4.03803  -52.93299 1.000 16.45980 ? 263 MET   B N   1 
ATOM   4012 C  CA  . MET   B 1 263 ? -31.33924 -4.40705  -54.25435 1.000 15.28918 ? 263 MET   B CA  1 
ATOM   4013 C  C   . MET   B 1 263 ? -30.84479 -3.18329  -55.03210 1.000 14.14586 ? 263 MET   B C   1 
ATOM   4014 O  O   . MET   B 1 263 ? -29.75239 -3.21321  -55.61726 1.000 14.56534 ? 263 MET   B O   1 
ATOM   4015 C  CB  . MET   B 1 263 ? -32.42888 -5.16508  -55.01376 1.000 17.47920 ? 263 MET   B CB  1 
ATOM   4016 C  CG  . MET   B 1 263 ? -32.70525 -6.57235  -54.45160 1.000 15.06311 ? 263 MET   B CG  1 
ATOM   4017 S  SD  . MET   B 1 263 ? -33.72373 -7.56324  -55.55732 1.000 22.38012 ? 263 MET   B SD  1 
ATOM   4018 C  CE  . MET   B 1 263 ? -35.27441 -6.67394  -55.51188 1.000 18.09215 ? 263 MET   B CE  1 
ATOM   4019 N  N   . VAL   B 1 264 ? -31.59582 -2.08229  -54.99064 1.000 14.01972 ? 264 VAL   B N   1 
ATOM   4020 C  CA  . VAL   B 1 264 ? -31.18285 -0.85356  -55.67256 1.000 13.40316 ? 264 VAL   B CA  1 
ATOM   4021 C  C   . VAL   B 1 264 ? -29.85071 -0.33295  -55.11687 1.000 16.14910 ? 264 VAL   B C   1 
ATOM   4022 O  O   . VAL   B 1 264 ? -28.93861 0.00763   -55.88124 1.000 13.52949 ? 264 VAL   B O   1 
ATOM   4023 C  CB  . VAL   B 1 264 ? -32.30337 0.20050   -55.57430 1.000 14.59382 ? 264 VAL   B CB  1 
ATOM   4024 C  CG1 . VAL   B 1 264 ? -31.85699 1.55178   -56.14608 1.000 10.67010 ? 264 VAL   B CG1 1 
ATOM   4025 C  CG2 . VAL   B 1 264 ? -33.55998 -0.29812  -56.29539 1.000 18.41773 ? 264 VAL   B CG2 1 
ATOM   4026 N  N   . ILE   B 1 265 ? -29.71995 -0.26011  -53.78480 1.000 14.22479 ? 265 ILE   B N   1 
ATOM   4027 C  CA  . ILE   B 1 265 ? -28.46193 0.15862   -53.15543 1.000 13.26753 ? 265 ILE   B CA  1 
ATOM   4028 C  C   . ILE   B 1 265 ? -27.30578 -0.74075  -53.59493 1.000 13.95269 ? 265 ILE   B C   1 
ATOM   4029 O  O   . ILE   B 1 265 ? -26.24186 -0.26046  -54.00699 1.000 12.89577 ? 265 ILE   B O   1 
ATOM   4030 C  CB  . ILE   B 1 265 ? -28.60633 0.16200   -51.62069 1.000 14.54463 ? 265 ILE   B CB  1 
ATOM   4031 C  CG1 . ILE   B 1 265 ? -29.49053 1.32443   -51.16926 1.000 11.69057 ? 265 ILE   B CG1 1 
ATOM   4032 C  CG2 . ILE   B 1 265 ? -27.20731 0.16449   -50.93869 1.000 12.77093 ? 265 ILE   B CG2 1 
ATOM   4033 C  CD1 . ILE   B 1 265 ? -30.03434 1.18048   -49.72880 1.000 11.86165 ? 265 ILE   B CD1 1 
ATOM   4034 N  N   . ASP   B 1 266 ? -27.49338 -2.06070  -53.49858 1.000 15.37544 ? 266 ASP   B N   1 
ATOM   4035 C  CA  . ASP   B 1 266 ? -26.45156 -2.99961  -53.91565 1.000 16.65714 ? 266 ASP   B CA  1 
ATOM   4036 C  C   . ASP   B 1 266 ? -26.07907 -2.81504  -55.38832 1.000 15.65724 ? 266 ASP   B C   1 
ATOM   4037 O  O   . ASP   B 1 266 ? -24.90983 -2.95678  -55.76024 1.000 17.05063 ? 266 ASP   B O   1 
ATOM   4038 C  CB  . ASP   B 1 266 ? -26.90358 -4.44782  -53.67787 1.000 20.67077 ? 266 ASP   B CB  1 
ATOM   4039 C  CG  . ASP   B 1 266 ? -26.89156 -4.85803  -52.20190 1.000 22.10471 ? 266 ASP   B CG  1 
ATOM   4040 O  OD1 . ASP   B 1 266 ? -26.24515 -4.19052  -51.38140 1.000 19.91811 ? 266 ASP   B OD1 1 
ATOM   4041 O  OD2 . ASP   B 1 266 ? -27.54403 -5.86786  -51.87658 1.000 27.48751 ? 266 ASP   B OD2 1 
ATOM   4042 N  N   . ILE   B 1 267 ? -27.05853 -2.53704  -56.24776 1.000 16.19035 ? 267 ILE   B N   1 
ATOM   4043 C  CA  . ILE   B 1 267 ? -26.76147 -2.38474  -57.67085 1.000 16.33821 ? 267 ILE   B CA  1 
ATOM   4044 C  C   . ILE   B 1 267 ? -25.99810 -1.08252  -57.92213 1.000 14.68153 ? 267 ILE   B C   1 
ATOM   4045 O  O   . ILE   B 1 267 ? -24.95838 -1.07278  -58.59172 1.000 14.38717 ? 267 ILE   B O   1 
ATOM   4046 C  CB  . ILE   B 1 267 ? -28.05615 -2.45590  -58.50407 1.000 16.26993 ? 267 ILE   B CB  1 
ATOM   4047 C  CG1 . ILE   B 1 267 ? -28.64322 -3.88758  -58.48856 1.000 17.74022 ? 267 ILE   B CG1 1 
ATOM   4048 C  CG2 . ILE   B 1 267 ? -27.79855 -1.98542  -59.96349 1.000 15.25463 ? 267 ILE   B CG2 1 
ATOM   4049 C  CD1 . ILE   B 1 267 ? -30.07254 -3.94913  -59.03158 1.000 15.91613 ? 267 ILE   B CD1 1 
ATOM   4050 N  N   . VAL   B 1 268 ? -26.49363 0.03083   -57.38216 1.000 10.15372 ? 268 VAL   B N   1 
ATOM   4051 C  CA  . VAL   B 1 268 ? -25.88326 1.31888   -57.69201 1.000 12.64249 ? 268 VAL   B CA  1 
ATOM   4052 C  C   . VAL   B 1 268 ? -24.48753 1.42141   -57.07972 1.000 14.05797 ? 268 VAL   B C   1 
ATOM   4053 O  O   . VAL   B 1 268 ? -23.55947 1.95232   -57.70692 1.000 13.18399 ? 268 VAL   B O   1 
ATOM   4054 C  CB  . VAL   B 1 268 ? -26.80319 2.46236   -57.24784 1.000 11.59290 ? 268 VAL   B CB  1 
ATOM   4055 C  CG1 . VAL   B 1 268 ? -26.11812 3.84554   -57.46575 1.000 9.02143  ? 268 VAL   B CG1 1 
ATOM   4056 C  CG2 . VAL   B 1 268 ? -28.10192 2.37956   -58.03683 1.000 10.64977 ? 268 VAL   B CG2 1 
ATOM   4057 N  N   . LEU   B 1 269 ? -24.29666 0.89563   -55.86939 1.000 11.12020 ? 269 LEU   B N   1 
ATOM   4058 C  CA  . LEU   B 1 269 ? -22.95265 0.95182   -55.29676 1.000 13.65594 ? 269 LEU   B CA  1 
ATOM   4059 C  C   . LEU   B 1 269 ? -21.96751 0.17623   -56.16579 1.000 16.02954 ? 269 LEU   B C   1 
ATOM   4060 O  O   . LEU   B 1 269 ? -20.77650 0.50847   -56.20340 1.000 14.85571 ? 269 LEU   B O   1 
ATOM   4061 C  CB  . LEU   B 1 269 ? -22.95196 0.43471   -53.84575 1.000 13.43856 ? 269 LEU   B CB  1 
ATOM   4062 C  CG  . LEU   B 1 269 ? -23.61545 1.34027   -52.77850 1.000 13.64715 ? 269 LEU   B CG  1 
ATOM   4063 C  CD1 . LEU   B 1 269 ? -23.50520 0.77834   -51.35072 1.000 15.02782 ? 269 LEU   B CD1 1 
ATOM   4064 C  CD2 . LEU   B 1 269 ? -23.03323 2.74681   -52.79356 1.000 13.46241 ? 269 LEU   B CD2 1 
ATOM   4065 N  N   . ALA   B 1 270 ? -22.45211 -0.82020  -56.91514 1.000 13.52550 ? 270 ALA   B N   1 
ATOM   4066 C  CA  . ALA   B 1 270 ? -21.55123 -1.59082  -57.75992 1.000 17.14896 ? 270 ALA   B CA  1 
ATOM   4067 C  C   . ALA   B 1 270 ? -21.17333 -0.86348  -59.04867 1.000 16.88826 ? 270 ALA   B C   1 
ATOM   4068 O  O   . ALA   B 1 270 ? -20.27763 -1.33170  -59.76127 1.000 18.06180 ? 270 ALA   B O   1 
ATOM   4069 C  CB  . ALA   B 1 270 ? -22.16673 -2.95260  -58.08875 1.000 17.08223 ? 270 ALA   B CB  1 
ATOM   4070 N  N   . THR   B 1 271 ? -21.80594 0.27064   -59.36597 1.000 13.35328 ? 271 THR   B N   1 
ATOM   4071 C  CA  . THR   B 1 271 ? -21.38089 0.99076   -60.56247 1.000 15.60781 ? 271 THR   B CA  1 
ATOM   4072 C  C   . THR   B 1 271 ? -20.07960 1.77807   -60.36330 1.000 15.55559 ? 271 THR   B C   1 
ATOM   4073 O  O   . THR   B 1 271 ? -19.49943 2.23406   -61.35258 1.000 15.99380 ? 271 THR   B O   1 
ATOM   4074 C  CB  . THR   B 1 271 ? -22.49196 1.92204   -61.04905 1.000 16.37402 ? 271 THR   B CB  1 
ATOM   4075 O  OG1 . THR   B 1 271 ? -22.77401 2.91049   -60.05267 1.000 13.09895 ? 271 THR   B OG1 1 
ATOM   4076 C  CG2 . THR   B 1 271 ? -23.76227 1.11836   -61.34931 1.000 15.26221 ? 271 THR   B CG2 1 
ATOM   4077 N  N   . ASP   B 1 272 ? -19.61002 1.93909   -59.12897 1.000 12.40237 ? 272 ASP   B N   1 
ATOM   4078 C  CA  . ASP   B 1 272 ? -18.31665 2.56676   -58.86302 1.000 14.99883 ? 272 ASP   B CA  1 
ATOM   4079 C  C   . ASP   B 1 272 ? -17.21518 1.81001   -59.60303 1.000 19.46511 ? 272 ASP   B C   1 
ATOM   4080 O  O   . ASP   B 1 272 ? -17.02472 0.60988   -59.38330 1.000 18.02145 ? 272 ASP   B O   1 
ATOM   4081 C  CB  . ASP   B 1 272 ? -18.08240 2.56475   -57.34371 1.000 16.00454 ? 272 ASP   B CB  1 
ATOM   4082 C  CG  . ASP   B 1 272 ? -16.77422 3.24168   -56.91053 1.000 18.92126 ? 272 ASP   B CG  1 
ATOM   4083 O  OD1 . ASP   B 1 272 ? -15.86034 3.44902   -57.73863 1.000 17.13206 ? 272 ASP   B OD1 1 
ATOM   4084 O  OD2 . ASP   B 1 272 ? -16.65731 3.52168   -55.69836 1.000 16.19659 ? 272 ASP   B OD2 1 
ATOM   4085 N  N   . MET   B 1 273 ? -16.51816 2.49602   -60.52169 1.000 15.26090 ? 273 MET   B N   1 
ATOM   4086 C  CA  . MET   B 1 273 ? -15.51925 1.80669   -61.34011 1.000 19.33878 ? 273 MET   B CA  1 
ATOM   4087 C  C   . MET   B 1 273 ? -14.37927 1.22848   -60.51443 1.000 18.95195 ? 273 MET   B C   1 
ATOM   4088 O  O   . MET   B 1 273 ? -13.68777 0.31864   -60.98414 1.000 22.61676 ? 273 MET   B O   1 
ATOM   4089 C  CB  . MET   B 1 273 ? -14.94751 2.73800   -62.41375 1.000 23.70045 ? 273 MET   B CB  1 
ATOM   4090 C  CG  . MET   B 1 273 ? -15.73199 2.73800   -63.72707 1.000 28.05623 ? 273 MET   B CG  1 
ATOM   4091 S  SD  . MET   B 1 273 ? -15.75587 1.13811   -64.55970 1.000 30.59971 ? 273 MET   B SD  1 
ATOM   4092 C  CE  . MET   B 1 273 ? -14.00943 0.86346   -64.77204 1.000 26.61370 ? 273 MET   B CE  1 
ATOM   4093 N  N   . SER   B 1 274 ? -14.16663 1.71397   -59.29093 1.000 25.12104 ? 274 SER   B N   1 
ATOM   4094 C  CA  . SER   B 1 274 ? -13.14477 1.09416   -58.45355 1.000 20.64221 ? 274 SER   B CA  1 
ATOM   4095 C  C   . SER   B 1 274 ? -13.52625 -0.31993  -58.01942 1.000 23.45689 ? 274 SER   B C   1 
ATOM   4096 O  O   . SER   B 1 274 ? -12.64936 -1.07029  -57.58097 1.000 24.42873 ? 274 SER   B O   1 
ATOM   4097 C  CB  . SER   B 1 274 ? -12.85938 1.96979   -57.23165 1.000 21.85751 ? 274 SER   B CB  1 
ATOM   4098 O  OG  . SER   B 1 274 ? -13.90985 1.88417   -56.28860 1.000 22.48411 ? 274 SER   B OG  1 
ATOM   4099 N  N   . LYS   B 1 275 ? -14.79474 -0.71287  -58.14851 1.000 20.84642 ? 275 LYS   B N   1 
ATOM   4100 C  CA  . LYS   B 1 275 ? -15.21445 -2.08279  -57.86872 1.000 21.02729 ? 275 LYS   B CA  1 
ATOM   4101 C  C   . LYS   B 1 275 ? -15.20807 -2.97932  -59.10635 1.000 22.51227 ? 275 LYS   B C   1 
ATOM   4102 O  O   . LYS   B 1 275 ? -15.59549 -4.14948  -58.99766 1.000 22.75428 ? 275 LYS   B O   1 
ATOM   4103 C  CB  . LYS   B 1 275 ? -16.62229 -2.10106  -57.26726 1.000 21.72962 ? 275 LYS   B CB  1 
ATOM   4104 C  CG  . LYS   B 1 275 ? -16.90782 -1.00090  -56.25842 1.000 26.31487 ? 275 LYS   B CG  1 
ATOM   4105 C  CD  . LYS   B 1 275 ? -16.93599 -1.51020  -54.83590 1.000 31.96194 ? 275 LYS   B CD  1 
ATOM   4106 C  CE  . LYS   B 1 275 ? -17.31688 -0.39598  -53.85257 1.000 28.33824 ? 275 LYS   B CE  1 
ATOM   4107 N  NZ  . LYS   B 1 275 ? -18.66466 0.22088   -54.09331 1.000 21.96425 ? 275 LYS   B NZ  1 
ATOM   4108 N  N   . HIS   B 1 276 ? -14.78560 -2.46686  -60.27130 1.000 18.87470 ? 276 HIS   B N   1 
ATOM   4109 C  CA  . HIS   B 1 276 ? -14.92518 -3.22141  -61.52429 1.000 21.80423 ? 276 HIS   B CA  1 
ATOM   4110 C  C   . HIS   B 1 276 ? -14.19670 -4.56557  -61.47184 1.000 19.58181 ? 276 HIS   B C   1 
ATOM   4111 O  O   . HIS   B 1 276 ? -14.77052 -5.60886  -61.80593 1.000 21.89033 ? 276 HIS   B O   1 
ATOM   4112 C  CB  . HIS   B 1 276 ? -14.40689 -2.39394  -62.71284 1.000 20.03590 ? 276 HIS   B CB  1 
ATOM   4113 C  CG  . HIS   B 1 276 ? -14.15846 -3.20618  -63.95299 1.000 19.09492 ? 276 HIS   B CG  1 
ATOM   4114 N  ND1 . HIS   B 1 276 ? -15.16678 -3.57751  -64.81877 1.000 21.30795 ? 276 HIS   B ND1 1 
ATOM   4115 C  CD2 . HIS   B 1 276 ? -13.01713 -3.72890  -64.46426 1.000 19.80901 ? 276 HIS   B CD2 1 
ATOM   4116 C  CE1 . HIS   B 1 276 ? -14.65781 -4.29082  -65.80881 1.000 18.97262 ? 276 HIS   B CE1 1 
ATOM   4117 N  NE2 . HIS   B 1 276 ? -13.35560 -4.39583  -65.61796 1.000 19.50785 ? 276 HIS   B NE2 1 
ATOM   4118 N  N   . MET   B 1 277 ? -12.92820 -4.55832  -61.07031 1.000 20.76495 ? 277 MET   B N   1 
ATOM   4119 C  CA  . MET   B 1 277 ? -12.13204 -5.78444  -61.13363 1.000 25.97291 ? 277 MET   B CA  1 
ATOM   4120 C  C   . MET   B 1 277 ? -12.70746 -6.89101  -60.24914 1.000 27.74536 ? 277 MET   B C   1 
ATOM   4121 O  O   . MET   B 1 277 ? -12.80390 -8.04866  -60.67759 1.000 23.75137 ? 277 MET   B O   1 
ATOM   4122 C  CB  . MET   B 1 277 ? -10.68811 -5.48000  -60.75873 1.000 23.95223 ? 277 MET   B CB  1 
ATOM   4123 C  CG  . MET   B 1 277 ? -9.95905  -4.59578  -61.79767 1.000 29.11958 ? 277 MET   B CG  1 
ATOM   4124 S  SD  . MET   B 1 277 ? -9.78772  -5.37343  -63.43474 1.000 43.90105 ? 277 MET   B SD  1 
ATOM   4125 C  CE  . MET   B 1 277 ? -8.96046  -4.06991  -64.36060 1.000 33.32187 ? 277 MET   B CE  1 
ATOM   4126 N  N   . ASN   B 1 278 ? -13.10228 -6.56353  -59.01589 1.000 26.97898 ? 278 ASN   B N   1 
ATOM   4127 C  CA  . ASN   B 1 278 ? -13.69894 -7.58379  -58.15458 1.000 24.48818 ? 278 ASN   B CA  1 
ATOM   4128 C  C   . ASN   B 1 278 ? -15.02012 -8.07059  -58.73115 1.000 28.94762 ? 278 ASN   B C   1 
ATOM   4129 O  O   . ASN   B 1 278 ? -15.31248 -9.27134  -58.72357 1.000 29.44058 ? 278 ASN   B O   1 
ATOM   4130 C  CB  . ASN   B 1 278 ? -13.90003 -7.03828  -56.73579 1.000 30.63748 ? 278 ASN   B CB  1 
ATOM   4131 C  CG  . ASN   B 1 278 ? -12.58820 -6.68886  -56.04584 1.000 35.37490 ? 278 ASN   B CG  1 
ATOM   4132 O  OD1 . ASN   B 1 278 ? -11.57583 -7.37352  -56.22154 1.000 39.18256 ? 278 ASN   B OD1 1 
ATOM   4133 N  ND2 . ASN   B 1 278 ? -12.59774 -5.61157  -55.26222 1.000 37.41494 ? 278 ASN   B ND2 1 
ATOM   4134 N  N   . LEU   B 1 279 ? -15.82899 -7.14511  -59.24367 1.000 27.84982 ? 279 LEU   B N   1 
ATOM   4135 C  CA  . LEU   B 1 279 ? -17.08317 -7.51977  -59.88000 1.000 26.04497 ? 279 LEU   B CA  1 
ATOM   4136 C  C   . LEU   B 1 279 ? -16.84516 -8.50416  -61.01760 1.000 28.64342 ? 279 LEU   B C   1 
ATOM   4137 O  O   . LEU   B 1 279 ? -17.59429 -9.47535  -61.18150 1.000 29.56494 ? 279 LEU   B O   1 
ATOM   4138 C  CB  . LEU   B 1 279 ? -17.77851 -6.25861  -60.39089 1.000 28.22848 ? 279 LEU   B CB  1 
ATOM   4139 C  CG  . LEU   B 1 279 ? -19.29557 -6.19243  -60.39678 1.000 26.61649 ? 279 LEU   B CG  1 
ATOM   4140 C  CD1 . LEU   B 1 279 ? -19.82540 -6.50650  -59.00137 1.000 23.61745 ? 279 LEU   B CD1 1 
ATOM   4141 C  CD2 . LEU   B 1 279 ? -19.74360 -4.80946  -60.87797 1.000 23.03595 ? 279 LEU   B CD2 1 
ATOM   4142 N  N   . LEU   B 1 280 ? -15.79400 -8.27610  -61.80499 1.000 27.65147 ? 280 LEU   B N   1 
ATOM   4143 C  CA  . LEU   B 1 280 ? -15.51824 -9.12972  -62.95795 1.000 28.79016 ? 280 LEU   B CA  1 
ATOM   4144 C  C   . LEU   B 1 280 ? -14.96739 -10.48768 -62.53323 1.000 28.00806 ? 280 LEU   B C   1 
ATOM   4145 O  O   . LEU   B 1 280 ? -15.33761 -11.51299 -63.11392 1.000 27.25383 ? 280 LEU   B O   1 
ATOM   4146 C  CB  . LEU   B 1 280 ? -14.54460 -8.42488  -63.90485 1.000 28.16017 ? 280 LEU   B CB  1 
ATOM   4147 C  CG  . LEU   B 1 280 ? -14.03300 -9.16958  -65.13238 1.000 26.41899 ? 280 LEU   B CG  1 
ATOM   4148 C  CD1 . LEU   B 1 280 ? -15.18381 -9.52821  -66.05093 1.000 23.91383 ? 280 LEU   B CD1 1 
ATOM   4149 C  CD2 . LEU   B 1 280 ? -12.98895 -8.30549  -65.86252 1.000 29.26027 ? 280 LEU   B CD2 1 
ATOM   4150 N  N   . ALA   B 1 281 ? -14.07385 -10.50916 -61.53920 1.000 31.29267 ? 281 ALA   B N   1 
ATOM   4151 C  CA  . ALA   B 1 281 ? -13.59314 -11.77609 -60.99952 1.000 29.60894 ? 281 ALA   B CA  1 
ATOM   4152 C  C   . ALA   B 1 281 ? -14.75998 -12.66011 -60.58554 1.000 35.76171 ? 281 ALA   B C   1 
ATOM   4153 O  O   . ALA   B 1 281 ? -14.80718 -13.85109 -60.91751 1.000 43.54008 ? 281 ALA   B O   1 
ATOM   4154 C  CB  . ALA   B 1 281 ? -12.66778 -11.51995 -59.81005 1.000 33.47267 ? 281 ALA   B CB  1 
ATOM   4155 N  N   . ASP   B 1 282 ? -15.73109 -12.07585 -59.88425 1.000 34.77468 ? 282 ASP   B N   1 
ATOM   4156 C  CA  . ASP   B 1 282 ? -16.88543 -12.83102 -59.42017 1.000 40.51066 ? 282 ASP   B CA  1 
ATOM   4157 C  C   . ASP   B 1 282 ? -17.79969 -13.22920 -60.57217 1.000 40.90438 ? 282 ASP   B C   1 
ATOM   4158 O  O   . ASP   B 1 282 ? -18.42309 -14.29785 -60.52798 1.000 39.56298 ? 282 ASP   B O   1 
ATOM   4159 C  CB  . ASP   B 1 282 ? -17.65072 -12.01269 -58.37794 1.000 41.83209 ? 282 ASP   B CB  1 
ATOM   4160 C  CG  . ASP   B 1 282 ? -16.90193 -11.88509 -57.06259 1.000 44.16528 ? 282 ASP   B CG  1 
ATOM   4161 O  OD1 . ASP   B 1 282 ? -15.91010 -12.62222 -56.85674 1.000 51.31786 ? 282 ASP   B OD1 1 
ATOM   4162 O  OD2 . ASP   B 1 282 ? -17.30910 -11.04086 -56.23546 1.000 42.65083 ? 282 ASP   B OD2 1 
ATOM   4163 N  N   . LEU   B 1 283 ? -17.90255 -12.39199 -61.60601 1.000 31.19170 ? 283 LEU   B N   1 
ATOM   4164 C  CA  . LEU   B 1 283 ? -18.66480 -12.79534 -62.78047 1.000 34.95035 ? 283 LEU   B CA  1 
ATOM   4165 C  C   . LEU   B 1 283 ? -18.00704 -13.97944 -63.48496 1.000 36.36775 ? 283 LEU   B C   1 
ATOM   4166 O  O   . LEU   B 1 283 ? -18.70172 -14.89424 -63.94719 1.000 35.54074 ? 283 LEU   B O   1 
ATOM   4167 C  CB  . LEU   B 1 283 ? -18.82073 -11.61286 -63.73278 1.000 33.12770 ? 283 LEU   B CB  1 
ATOM   4168 C  CG  . LEU   B 1 283 ? -19.59728 -11.88885 -65.01294 1.000 33.69083 ? 283 LEU   B CG  1 
ATOM   4169 C  CD1 . LEU   B 1 283 ? -21.07388 -12.11794 -64.72497 1.000 29.30744 ? 283 LEU   B CD1 1 
ATOM   4170 C  CD2 . LEU   B 1 283 ? -19.39993 -10.73536 -65.98464 1.000 32.57815 ? 283 LEU   B CD2 1 
ATOM   4171 N  N   . LYS   B 1 284 ? -16.67064 -13.98245 -63.57279 1.000 34.22928 ? 284 LYS   B N   1 
ATOM   4172 C  CA  . LYS   B 1 284 ? -15.95986 -15.10834 -64.18149 1.000 36.80371 ? 284 LYS   B CA  1 
ATOM   4173 C  C   . LYS   B 1 284 ? -16.18294 -16.39112 -63.38947 1.000 37.42206 ? 284 LYS   B C   1 
ATOM   4174 O  O   . LYS   B 1 284 ? -16.46834 -17.44802 -63.96403 1.000 37.60038 ? 284 LYS   B O   1 
ATOM   4175 C  CB  . LYS   B 1 284 ? -14.46156 -14.80682 -64.28039 1.000 30.09761 ? 284 LYS   B CB  1 
ATOM   4176 C  CG  . LYS   B 1 284 ? -14.08041 -13.84023 -65.39002 1.000 31.68454 ? 284 LYS   B CG  1 
ATOM   4177 C  CD  . LYS   B 1 284 ? -12.58052 -13.58744 -65.40898 1.000 32.06494 ? 284 LYS   B CD  1 
ATOM   4178 C  CE  . LYS   B 1 284 ? -12.18067 -12.59615 -66.50698 1.000 31.86482 ? 284 LYS   B CE  1 
ATOM   4179 N  NZ  . LYS   B 1 284 ? -10.72680 -12.21873 -66.40396 1.000 30.97502 ? 284 LYS   B NZ  1 
ATOM   4180 N  N   . THR   B 1 285 ? -16.02436 -16.31714 -62.06658 1.000 35.97834 ? 285 THR   B N   1 
ATOM   4181 C  CA  . THR   B 1 285 ? -16.30790 -17.45950 -61.20732 1.000 39.39883 ? 285 THR   B CA  1 
ATOM   4182 C  C   . THR   B 1 285 ? -17.67736 -18.04802 -61.51007 1.000 38.22181 ? 285 THR   B C   1 
ATOM   4183 O  O   . THR   B 1 285 ? -17.82491 -19.26178 -61.69212 1.000 43.31972 ? 285 THR   B O   1 
ATOM   4184 C  CB  . THR   B 1 285 ? -16.22255 -17.02993 -59.74950 1.000 35.30218 ? 285 THR   B CB  1 
ATOM   4185 O  OG1 . THR   B 1 285 ? -14.84530 -16.85692 -59.39609 1.000 32.46170 ? 285 THR   B OG1 1 
ATOM   4186 C  CG2 . THR   B 1 285 ? -16.88130 -18.06356 -58.84607 1.000 39.30853 ? 285 THR   B CG2 1 
ATOM   4187 N  N   . MET   B 1 286 ? -18.68851 -17.19027 -61.59685 1.000 32.53931 ? 286 MET   B N   1 
ATOM   4188 C  CA  . MET   B 1 286 ? -20.03519 -17.66283 -61.88313 1.000 34.32219 ? 286 MET   B CA  1 
ATOM   4189 C  C   . MET   B 1 286 ? -20.13161 -18.30117 -63.26632 1.000 41.59694 ? 286 MET   B C   1 
ATOM   4190 O  O   . MET   B 1 286 ? -20.92939 -19.22475 -63.47178 1.000 44.91281 ? 286 MET   B O   1 
ATOM   4191 C  CB  . MET   B 1 286 ? -21.01927 -16.50234 -61.74449 1.000 33.99856 ? 286 MET   B CB  1 
ATOM   4192 C  CG  . MET   B 1 286 ? -22.37752 -16.77386 -62.36754 1.000 34.19055 ? 286 MET   B CG  1 
ATOM   4193 S  SD  . MET   B 1 286 ? -23.71526 -15.77792 -61.69785 1.000 44.91544 ? 286 MET   B SD  1 
ATOM   4194 C  CE  . MET   B 1 286 ? -22.90781 -14.94266 -60.34227 1.000 29.91770 ? 286 MET   B CE  1 
ATOM   4195 N  N   . VAL   B 1 287 ? -19.32519 -17.84394 -64.22326 1.000 37.28178 ? 287 VAL   B N   1 
ATOM   4196 C  CA  . VAL   B 1 287 ? -19.37135 -18.43423 -65.55693 1.000 40.98004 ? 287 VAL   B CA  1 
ATOM   4197 C  C   . VAL   B 1 287 ? -18.85477 -19.87039 -65.52888 1.000 42.27832 ? 287 VAL   B C   1 
ATOM   4198 O  O   . VAL   B 1 287 ? -19.47258 -20.77531 -66.10100 1.000 48.43409 ? 287 VAL   B O   1 
ATOM   4199 C  CB  . VAL   B 1 287 ? -18.59373 -17.56436 -66.56125 1.000 39.41424 ? 287 VAL   B CB  1 
ATOM   4200 C  CG1 . VAL   B 1 287 ? -18.29358 -18.34829 -67.82478 1.000 35.64272 ? 287 VAL   B CG1 1 
ATOM   4201 C  CG2 . VAL   B 1 287 ? -19.40678 -16.33800 -66.90729 1.000 35.44996 ? 287 VAL   B CG2 1 
ATOM   4202 N  N   . GLU   B 1 288 ? -17.72911 -20.10988 -64.85117 1.000 38.11150 ? 288 GLU   B N   1 
ATOM   4203 C  CA  . GLU   B 1 288 ? -17.12359 -21.43475 -64.90679 1.000 43.41744 ? 288 GLU   B CA  1 
ATOM   4204 C  C   . GLU   B 1 288 ? -17.86144 -22.46951 -64.06212 1.000 48.50088 ? 288 GLU   B C   1 
ATOM   4205 O  O   . GLU   B 1 288 ? -17.56176 -23.66292 -64.18468 1.000 48.87375 ? 288 GLU   B O   1 
ATOM   4206 C  CB  . GLU   B 1 288 ? -15.64947 -21.35947 -64.49188 1.000 44.16960 ? 288 GLU   B CB  1 
ATOM   4207 C  CG  . GLU   B 1 288 ? -15.39686 -20.81264 -63.09784 1.000 47.53261 ? 288 GLU   B CG  1 
ATOM   4208 C  CD  . GLU   B 1 288 ? -13.93603 -20.44111 -62.87316 1.000 55.54367 ? 288 GLU   B CD  1 
ATOM   4209 O  OE1 . GLU   B 1 288 ? -13.15116 -20.51130 -63.84721 1.000 56.76031 ? 288 GLU   B OE1 1 
ATOM   4210 O  OE2 . GLU   B 1 288 ? -13.57168 -20.08441 -61.72551 1.000 51.44804 ? 288 GLU   B OE2 1 
ATOM   4211 N  N   . THR   B 1 289 ? -18.80982 -22.05178 -63.21631 1.000 46.69743 ? 289 THR   B N   1 
ATOM   4212 C  CA  . THR   B 1 289 ? -19.65776 -22.96458 -62.45280 1.000 47.31407 ? 289 THR   B CA  1 
ATOM   4213 C  C   . THR   B 1 289 ? -21.12708 -22.78366 -62.83138 1.000 45.46175 ? 289 THR   B C   1 
ATOM   4214 O  O   . THR   B 1 289 ? -22.02653 -23.00948 -62.02222 1.000 51.95692 ? 289 THR   B O   1 
ATOM   4215 C  CB  . THR   B 1 289 ? -19.45294 -22.77329 -60.94922 1.000 47.34675 ? 289 THR   B CB  1 
ATOM   4216 O  OG1 . THR   B 1 289 ? -20.06735 -21.55007 -60.53071 1.000 44.39842 ? 289 THR   B OG1 1 
ATOM   4217 C  CG2 . THR   B 1 289 ? -17.97200 -22.71633 -60.61709 1.000 41.49244 ? 289 THR   B CG2 1 
ATOM   4218 N  N   . LYS   B 1 290 ? -21.36468 -22.38223 -64.07527 1.000 42.37205 ? 290 LYS   B N   1 
ATOM   4219 C  CA  . LYS   B 1 290 ? -22.67806 -22.05203 -64.60635 1.000 44.30913 ? 290 LYS   B CA  1 
ATOM   4220 C  C   . LYS   B 1 290 ? -23.55078 -23.30566 -64.73185 1.000 48.15341 ? 290 LYS   B C   1 
ATOM   4221 O  O   . LYS   B 1 290 ? -23.05085 -24.42944 -64.83722 1.000 50.42990 ? 290 LYS   B O   1 
ATOM   4222 C  CB  . LYS   B 1 290 ? -22.48963 -21.35381 -65.95842 1.000 41.51116 ? 290 LYS   B CB  1 
ATOM   4223 C  CG  . LYS   B 1 290 ? -23.67905 -21.29264 -66.89355 1.000 47.48538 ? 290 LYS   B CG  1 
ATOM   4224 C  CD  . LYS   B 1 290 ? -23.45903 -20.24313 -67.98196 1.000 44.78973 ? 290 LYS   B CD  1 
ATOM   4225 C  CE  . LYS   B 1 290 ? -22.92026 -20.84418 -69.27351 1.000 40.16459 ? 290 LYS   B CE  1 
ATOM   4226 N  NZ  . LYS   B 1 290 ? -23.84706 -20.55823 -70.41572 1.000 44.45855 ? 290 LYS   B NZ  1 
ATOM   4227 N  N   . LYS   B 1 291 ? -24.87846 -23.10092 -64.69996 1.000 43.65941 ? 291 LYS   B N   1 
ATOM   4228 C  CA  . LYS   B 1 291 ? -25.85951 -24.17458 -64.85350 1.000 43.52349 ? 291 LYS   B CA  1 
ATOM   4229 C  C   . LYS   B 1 291 ? -27.06903 -23.67729 -65.64018 1.000 43.88999 ? 291 LYS   B C   1 
ATOM   4230 O  O   . LYS   B 1 291 ? -27.51672 -22.54273 -65.44511 1.000 45.24155 ? 291 LYS   B O   1 
ATOM   4231 C  CB  . LYS   B 1 291 ? -26.30353 -24.72265 -63.49067 1.000 44.66640 ? 291 LYS   B CB  1 
ATOM   4232 C  CG  . LYS   B 1 291 ? -25.22904 -25.50307 -62.76429 1.000 47.18322 ? 291 LYS   B CG  1 
ATOM   4233 C  CD  . LYS   B 1 291 ? -25.44419 -25.49477 -61.26354 1.000 50.44180 ? 291 LYS   B CD  1 
ATOM   4234 C  CE  . LYS   B 1 291 ? -24.11463 -25.39621 -60.52813 1.000 54.68017 ? 291 LYS   B CE  1 
ATOM   4235 N  NZ  . LYS   B 1 291 ? -24.02065 -26.32803 -59.36835 1.000 49.79424 ? 291 LYS   B NZ  1 
ATOM   4236 N  N   . VAL   B 1 292 ? -27.60952 -24.55104 -66.50709 1.000 40.61834 ? 292 VAL   B N   1 
ATOM   4237 C  CA  . VAL   B 1 292 ? -28.54339 -24.19172 -67.57647 1.000 47.81927 ? 292 VAL   B CA  1 
ATOM   4238 C  C   . VAL   B 1 292 ? -29.72849 -25.15698 -67.58559 1.000 47.64184 ? 292 VAL   B C   1 
ATOM   4239 O  O   . VAL   B 1 292 ? -29.54867 -26.35605 -67.35124 1.000 41.45924 ? 292 VAL   B O   1 
ATOM   4240 C  CB  . VAL   B 1 292 ? -27.83908 -24.23999 -68.95176 1.000 47.36749 ? 292 VAL   B CB  1 
ATOM   4241 C  CG1 . VAL   B 1 292 ? -28.64936 -23.50179 -70.00682 1.000 50.20372 ? 292 VAL   B CG1 1 
ATOM   4242 C  CG2 . VAL   B 1 292 ? -26.40281 -23.72076 -68.86037 1.000 45.95868 ? 292 VAL   B CG2 1 
ATOM   4243 N  N   . THR   B 1 293 ? -30.93965 -24.64705 -67.88397 1.000 53.52083 ? 293 THR   B N   1 
ATOM   4244 C  CA  . THR   B 1 293 ? -32.08470 -25.53056 -68.11461 1.000 54.52261 ? 293 THR   B CA  1 
ATOM   4245 C  C   . THR   B 1 293 ? -32.02224 -26.08324 -69.53595 1.000 58.53148 ? 293 THR   B C   1 
ATOM   4246 O  O   . THR   B 1 293 ? -31.04236 -25.90302 -70.26460 1.000 60.11944 ? 293 THR   B O   1 
ATOM   4247 C  CB  . THR   B 1 293 ? -33.45731 -24.85788 -67.92546 1.000 57.20216 ? 293 THR   B CB  1 
ATOM   4248 O  OG1 . THR   B 1 293 ? -33.84685 -24.16797 -69.12026 1.000 59.21372 ? 293 THR   B OG1 1 
ATOM   4249 C  CG2 . THR   B 1 293 ? -33.55136 -23.92752 -66.74171 1.000 59.79745 ? 293 THR   B CG2 1 
ATOM   4250 N  N   . SER   B 1 294 ? -33.11278 -26.74096 -69.94766 1.000 66.15785 ? 294 SER   B N   1 
ATOM   4251 C  CA  . SER   B 1 294 ? -33.18616 -27.36430 -71.26634 1.000 64.70042 ? 294 SER   B CA  1 
ATOM   4252 C  C   . SER   B 1 294 ? -33.36298 -26.31886 -72.36454 1.000 64.92578 ? 294 SER   B C   1 
ATOM   4253 O  O   . SER   B 1 294 ? -32.57858 -26.28204 -73.33272 1.000 62.40312 ? 294 SER   B O   1 
ATOM   4254 C  CB  . SER   B 1 294 ? -34.32194 -28.39699 -71.29002 1.000 63.54427 ? 294 SER   B CB  1 
ATOM   4255 O  OG  . SER   B 1 294 ? -35.55543 -27.86740 -70.80714 1.000 59.60877 ? 294 SER   B OG  1 
ATOM   4256 N  N   . SER   B 1 295 ? -34.38728 -25.45235 -72.22131 1.000 67.03381 ? 295 SER   B N   1 
ATOM   4257 C  CA  . SER   B 1 295 ? -34.61134 -24.35151 -73.15718 1.000 67.53097 ? 295 SER   B CA  1 
ATOM   4258 C  C   . SER   B 1 295 ? -33.49143 -23.32423 -73.13683 1.000 70.05008 ? 295 SER   B C   1 
ATOM   4259 O  O   . SER   B 1 295 ? -33.44494 -22.46288 -74.02274 1.000 72.66317 ? 295 SER   B O   1 
ATOM   4260 C  CB  . SER   B 1 295 ? -35.90328 -23.57687 -72.79210 1.000 61.37112 ? 295 SER   B CB  1 
ATOM   4261 O  OG  . SER   B 1 295 ? -35.79078 -22.92842 -71.54054 1.000 60.70943 ? 295 SER   B OG  1 
ATOM   4262 N  N   . GLY   B 1 296 ? -32.62289 -23.36996 -72.12962 1.000 69.32820 ? 296 GLY   B N   1 
ATOM   4263 C  CA  . GLY   B 1 296 ? -31.47545 -22.48659 -72.02518 1.000 64.19005 ? 296 GLY   B CA  1 
ATOM   4264 C  C   . GLY   B 1 296 ? -31.45083 -21.54327 -70.82893 1.000 59.21396 ? 296 GLY   B C   1 
ATOM   4265 O  O   . GLY   B 1 296 ? -30.39799 -20.93679 -70.58097 1.000 60.68064 ? 296 GLY   B O   1 
ATOM   4266 N  N   . VAL   B 1 297 ? -32.53565 -21.37330 -70.06694 1.000 54.57588 ? 297 VAL   B N   1 
ATOM   4267 C  CA  . VAL   B 1 297 ? -32.56441 -20.34924 -69.01968 1.000 53.75354 ? 297 VAL   B CA  1 
ATOM   4268 C  C   . VAL   B 1 297 ? -31.54241 -20.68570 -67.93714 1.000 51.77001 ? 297 VAL   B C   1 
ATOM   4269 O  O   . VAL   B 1 297 ? -31.55222 -21.78231 -67.36972 1.000 50.28302 ? 297 VAL   B O   1 
ATOM   4270 C  CB  . VAL   B 1 297 ? -33.98091 -20.20749 -68.44201 1.000 56.44514 ? 297 VAL   B CB  1 
ATOM   4271 C  CG1 . VAL   B 1 297 ? -34.10755 -18.93306 -67.60933 1.000 53.71957 ? 297 VAL   B CG1 1 
ATOM   4272 C  CG2 . VAL   B 1 297 ? -35.02220 -20.22125 -69.55996 1.000 59.23415 ? 297 VAL   B CG2 1 
ATOM   4273 N  N   . LEU   B 1 298 ? -30.63815 -19.74372 -67.66458 1.000 51.56938 ? 298 LEU   B N   1 
ATOM   4274 C  CA  . LEU   B 1 298 ? -29.64036 -19.88850 -66.60742 1.000 45.88546 ? 298 LEU   B CA  1 
ATOM   4275 C  C   . LEU   B 1 298 ? -30.31571 -20.16273 -65.26432 1.000 34.87930 ? 298 LEU   B C   1 
ATOM   4276 O  O   . LEU   B 1 298 ? -31.42227 -19.68458 -65.00318 1.000 39.51987 ? 298 LEU   B O   1 
ATOM   4277 C  CB  . LEU   B 1 298 ? -28.80784 -18.60130 -66.54683 1.000 41.29494 ? 298 LEU   B CB  1 
ATOM   4278 C  CG  . LEU   B 1 298 ? -27.58754 -18.40328 -65.65846 1.000 37.40049 ? 298 LEU   B CG  1 
ATOM   4279 C  CD1 . LEU   B 1 298 ? -26.36316 -19.02842 -66.28803 1.000 37.34942 ? 298 LEU   B CD1 1 
ATOM   4280 C  CD2 . LEU   B 1 298 ? -27.35612 -16.91433 -65.46208 1.000 41.85547 ? 298 LEU   B CD2 1 
ATOM   4281 N  N   . LEU   B 1 299 ? -29.64675 -20.93111 -64.39845 1.000 37.03301 ? 299 LEU   B N   1 
ATOM   4282 C  CA  . LEU   B 1 299 ? -30.18092 -21.27703 -63.07680 1.000 35.46332 ? 299 LEU   B CA  1 
ATOM   4283 C  C   . LEU   B 1 299 ? -29.35470 -20.62480 -61.98047 1.000 31.06203 ? 299 LEU   B C   1 
ATOM   4284 O  O   . LEU   B 1 299 ? -28.20942 -21.02662 -61.74661 1.000 34.58278 ? 299 LEU   B O   1 
ATOM   4285 C  CB  . LEU   B 1 299 ? -30.19251 -22.78554 -62.82550 1.000 33.84384 ? 299 LEU   B CB  1 
ATOM   4286 C  CG  . LEU   B 1 299 ? -31.23562 -23.71736 -63.43499 1.000 37.73262 ? 299 LEU   B CG  1 
ATOM   4287 C  CD1 . LEU   B 1 299 ? -32.66429 -23.19397 -63.27690 1.000 36.44323 ? 299 LEU   B CD1 1 
ATOM   4288 C  CD2 . LEU   B 1 299 ? -30.88079 -23.89490 -64.83386 1.000 39.16291 ? 299 LEU   B CD2 1 
ATOM   4289 N  N   . LEU   B 1 300 ? -29.95274 -19.66966 -61.27684 1.000 28.16456 ? 300 LEU   B N   1 
ATOM   4290 C  CA  . LEU   B 1 300 ? -29.35142 -19.04386 -60.10351 1.000 34.39798 ? 300 LEU   B CA  1 
ATOM   4291 C  C   . LEU   B 1 300 ? -30.25314 -19.33298 -58.91474 1.000 27.92502 ? 300 LEU   B C   1 
ATOM   4292 O  O   . LEU   B 1 300 ? -31.45518 -19.06305 -58.97595 1.000 32.29597 ? 300 LEU   B O   1 
ATOM   4293 C  CB  . LEU   B 1 300 ? -29.19612 -17.52417 -60.27882 1.000 33.20167 ? 300 LEU   B CB  1 
ATOM   4294 C  CG  . LEU   B 1 300 ? -28.38629 -16.95319 -61.40466 1.000 34.97128 ? 300 LEU   B CG  1 
ATOM   4295 C  CD1 . LEU   B 1 300 ? -27.17736 -17.69350 -61.61338 1.000 36.85519 ? 300 LEU   B CD1 1 
ATOM   4296 C  CD2 . LEU   B 1 300 ? -29.16961 -16.90612 -62.63668 1.000 38.39199 ? 300 LEU   B CD2 1 
ATOM   4297 N  N   . ASP   B 1 301 ? -29.69335 -19.87926 -57.83967 1.000 32.10016 ? 301 ASP   B N   1 
ATOM   4298 C  CA  . ASP   B 1 301 ? -30.57168 -20.29590 -56.75071 1.000 36.39970 ? 301 ASP   B CA  1 
ATOM   4299 C  C   . ASP   B 1 301 ? -30.61951 -19.32477 -55.57958 1.000 33.75558 ? 301 ASP   B C   1 
ATOM   4300 O  O   . ASP   B 1 301 ? -31.68860 -19.14545 -54.98818 1.000 36.55085 ? 301 ASP   B O   1 
ATOM   4301 C  CB  . ASP   B 1 301 ? -30.18908 -21.67811 -56.21872 1.000 34.27335 ? 301 ASP   B CB  1 
ATOM   4302 C  CG  . ASP   B 1 301 ? -31.25352 -22.23338 -55.28361 1.000 22.84401 ? 301 ASP   B CG  1 
ATOM   4303 O  OD1 . ASP   B 1 301 ? -32.43354 -22.24612 -55.69011 1.000 21.83763 ? 301 ASP   B OD1 1 
ATOM   4304 O  OD2 . ASP   B 1 301 ? -30.92546 -22.60099 -54.13961 1.000 22.08041 ? 301 ASP   B OD2 1 
ATOM   4305 N  N   . ASN   B 1 302 ? -29.50513 -18.70250 -55.20801 1.000 32.29037 ? 302 ASN   B N   1 
ATOM   4306 C  CA  . ASN   B 1 302 ? -29.48904 -17.85032 -54.02713 1.000 36.98184 ? 302 ASN   B CA  1 
ATOM   4307 C  C   . ASN   B 1 302 ? -29.40140 -16.37970 -54.42047 1.000 34.41560 ? 302 ASN   B C   1 
ATOM   4308 O  O   . ASN   B 1 302 ? -28.93073 -16.03711 -55.51184 1.000 32.78861 ? 302 ASN   B O   1 
ATOM   4309 C  CB  . ASN   B 1 302 ? -28.33022 -18.22205 -53.09852 1.000 36.98390 ? 302 ASN   B CB  1 
ATOM   4310 C  CG  . ASN   B 1 302 ? -27.00205 -18.23954 -53.81306 1.000 41.52795 ? 302 ASN   B CG  1 
ATOM   4311 O  OD1 . ASN   B 1 302 ? -26.48155 -17.19009 -54.19263 1.000 43.47817 ? 302 ASN   B OD1 1 
ATOM   4312 N  ND2 . ASN   B 1 302 ? -26.44181 -19.43247 -54.00528 1.000 43.83446 ? 302 ASN   B ND2 1 
ATOM   4313 N  N   . TYR   B 1 303 ? -29.87670 -15.51850 -53.51251 1.000 29.44116 ? 303 TYR   B N   1 
ATOM   4314 C  CA  . TYR   B 1 303 ? -29.84454 -14.07767 -53.73831 1.000 33.20270 ? 303 TYR   B CA  1 
ATOM   4315 C  C   . TYR   B 1 303 ? -28.44429 -13.60287 -54.10741 1.000 27.55044 ? 303 TYR   B C   1 
ATOM   4316 O  O   . TYR   B 1 303 ? -28.28600 -12.75291 -54.98771 1.000 29.82660 ? 303 TYR   B O   1 
ATOM   4317 C  CB  . TYR   B 1 303 ? -30.35119 -13.32839 -52.49715 1.000 30.94298 ? 303 TYR   B CB  1 
ATOM   4318 C  CG  . TYR   B 1 303 ? -30.16991 -11.81450 -52.58321 1.000 32.54537 ? 303 TYR   B CG  1 
ATOM   4319 C  CD1 . TYR   B 1 303 ? -31.04923 -11.02652 -53.32131 1.000 31.09593 ? 303 TYR   B CD1 1 
ATOM   4320 C  CD2 . TYR   B 1 303 ? -29.11390 -11.18121 -51.93932 1.000 29.21616 ? 303 TYR   B CD2 1 
ATOM   4321 C  CE1 . TYR   B 1 303 ? -30.88189 -9.65423  -53.41596 1.000 30.69983 ? 303 TYR   B CE1 1 
ATOM   4322 C  CE2 . TYR   B 1 303 ? -28.93661 -9.81088  -52.02733 1.000 32.44223 ? 303 TYR   B CE2 1 
ATOM   4323 C  CZ  . TYR   B 1 303 ? -29.82385 -9.04600  -52.76799 1.000 32.21466 ? 303 TYR   B CZ  1 
ATOM   4324 O  OH  . TYR   B 1 303 ? -29.65466 -7.67072  -52.85610 1.000 34.70931 ? 303 TYR   B OH  1 
ATOM   4325 N  N   . SER   B 1 304 ? -27.41608 -14.16019 -53.46207 1.000 25.72709 ? 304 SER   B N   1 
ATOM   4326 C  CA  . SER   B 1 304 ? -26.04726 -13.70056 -53.68556 1.000 32.27360 ? 304 SER   B CA  1 
ATOM   4327 C  C   . SER   B 1 304 ? -25.67755 -13.73899 -55.16693 1.000 34.55115 ? 304 SER   B C   1 
ATOM   4328 O  O   . SER   B 1 304 ? -25.15062 -12.76453 -55.71353 1.000 30.46747 ? 304 SER   B O   1 
ATOM   4329 C  CB  . SER   B 1 304 ? -25.07409 -14.54462 -52.86315 1.000 35.86424 ? 304 SER   B CB  1 
ATOM   4330 O  OG  . SER   B 1 304 ? -23.73620 -14.20906 -53.16900 1.000 44.02414 ? 304 SER   B OG  1 
ATOM   4331 N  N   . ASP   B 1 305 ? -25.96517 -14.85297 -55.84082 1.000 29.37908 ? 305 ASP   B N   1 
ATOM   4332 C  CA  . ASP   B 1 305 ? -25.64691 -14.92870 -57.25815 1.000 28.20594 ? 305 ASP   B CA  1 
ATOM   4333 C  C   . ASP   B 1 305 ? -26.57295 -14.04565 -58.08915 1.000 29.55948 ? 305 ASP   B C   1 
ATOM   4334 O  O   . ASP   B 1 305 ? -26.12014 -13.42662 -59.05772 1.000 28.47448 ? 305 ASP   B O   1 
ATOM   4335 C  CB  . ASP   B 1 305 ? -25.69949 -16.37882 -57.73065 1.000 29.33126 ? 305 ASP   B CB  1 
ATOM   4336 C  CG  . ASP   B 1 305 ? -24.57251 -17.21859 -57.14966 1.000 33.63242 ? 305 ASP   B CG  1 
ATOM   4337 O  OD1 . ASP   B 1 305 ? -23.64140 -16.64621 -56.54336 1.000 38.82746 ? 305 ASP   B OD1 1 
ATOM   4338 O  OD2 . ASP   B 1 305 ? -24.60807 -18.45363 -57.31233 1.000 34.81344 ? 305 ASP   B OD2 1 
ATOM   4339 N  N   . ARG   B 1 306 ? -27.85183 -13.93795 -57.70890 1.000 24.24202 ? 306 ARG   B N   1 
ATOM   4340 C  CA  . ARG   B 1 306 ? -28.81159 -13.17875 -58.51383 1.000 27.60735 ? 306 ARG   B CA  1 
ATOM   4341 C  C   . ARG   B 1 306 ? -28.53872 -11.67411 -58.47793 1.000 32.22618 ? 306 ARG   B C   1 
ATOM   4342 O  O   . ARG   B 1 306 ? -28.72883 -10.98056 -59.48642 1.000 23.06260 ? 306 ARG   B O   1 
ATOM   4343 C  CB  . ARG   B 1 306 ? -30.23510 -13.45935 -58.03895 1.000 28.65508 ? 306 ARG   B CB  1 
ATOM   4344 C  CG  . ARG   B 1 306 ? -30.81018 -14.75404 -58.57422 1.000 35.17811 ? 306 ARG   B CG  1 
ATOM   4345 C  CD  . ARG   B 1 306 ? -32.33234 -14.68380 -58.72717 1.000 34.46032 ? 306 ARG   B CD  1 
ATOM   4346 N  NE  . ARG   B 1 306 ? -32.98793 -14.36455 -57.46613 1.000 36.51310 ? 306 ARG   B NE  1 
ATOM   4347 C  CZ  . ARG   B 1 306 ? -33.09313 -15.20885 -56.44462 1.000 40.77133 ? 306 ARG   B CZ  1 
ATOM   4348 N  NH1 . ARG   B 1 306 ? -32.59415 -16.43794 -56.54109 1.000 41.84102 ? 306 ARG   B NH1 1 
ATOM   4349 N  NH2 . ARG   B 1 306 ? -33.70421 -14.82760 -55.32706 1.000 44.91275 ? 306 ARG   B NH2 1 
ATOM   4350 N  N   . ILE   B 1 307 ? -28.13699 -11.14433 -57.31855 1.000 25.18315 ? 307 ILE   B N   1 
ATOM   4351 C  CA  . ILE   B 1 307 ? -27.82257 -9.72503  -57.23745 1.000 23.81433 ? 307 ILE   B CA  1 
ATOM   4352 C  C   . ILE   B 1 307 ? -26.52075 -9.44706  -57.96317 1.000 23.47688 ? 307 ILE   B C   1 
ATOM   4353 O  O   . ILE   B 1 307 ? -26.34612 -8.38477  -58.56740 1.000 23.45632 ? 307 ILE   B O   1 
ATOM   4354 C  CB  . ILE   B 1 307 ? -27.76356 -9.25561  -55.76803 1.000 24.06331 ? 307 ILE   B CB  1 
ATOM   4355 C  CG1 . ILE   B 1 307 ? -27.71252 -7.72893  -55.70996 1.000 23.23457 ? 307 ILE   B CG1 1 
ATOM   4356 C  CG2 . ILE   B 1 307 ? -26.55840 -9.85482  -55.02377 1.000 22.67920 ? 307 ILE   B CG2 1 
ATOM   4357 C  CD1 . ILE   B 1 307 ? -28.98386 -7.09010  -56.20639 1.000 20.63060 ? 307 ILE   B CD1 1 
ATOM   4358 N  N   . GLN   B 1 308 ? -25.59994 -10.40412 -57.92816 1.000 25.24860 ? 308 GLN   B N   1 
ATOM   4359 C  CA  . GLN   B 1 308 ? -24.32133 -10.26083 -58.60121 1.000 25.58154 ? 308 GLN   B CA  1 
ATOM   4360 C  C   . GLN   B 1 308 ? -24.49141 -10.19110 -60.11505 1.000 28.44833 ? 308 GLN   B C   1 
ATOM   4361 O  O   . GLN   B 1 308 ? -23.75285 -9.46215  -60.79059 1.000 23.31721 ? 308 GLN   B O   1 
ATOM   4362 C  CB  . GLN   B 1 308 ? -23.43403 -11.42301 -58.18718 1.000 33.46480 ? 308 GLN   B CB  1 
ATOM   4363 C  CG  . GLN   B 1 308 ? -22.27183 -11.68047 -59.06362 1.000 34.58544 ? 308 GLN   B CG  1 
ATOM   4364 C  CD  . GLN   B 1 308 ? -21.39092 -12.73778 -58.47406 1.000 46.39805 ? 308 GLN   B CD  1 
ATOM   4365 O  OE1 . GLN   B 1 308 ? -20.33288 -13.04823 -59.01401 1.000 49.22521 ? 308 GLN   B OE1 1 
ATOM   4366 N  NE2 . GLN   B 1 308 ? -21.83548 -13.31418 -57.34156 1.000 43.67922 ? 308 GLN   B NE2 1 
ATOM   4367 N  N   . VAL   B 1 309 ? -25.47103 -10.92084 -60.66472 1.000 23.10094 ? 309 VAL   B N   1 
ATOM   4368 C  CA  . VAL   B 1 309 ? -25.76353 -10.79592 -62.08960 1.000 21.98158 ? 309 VAL   B CA  1 
ATOM   4369 C  C   . VAL   B 1 309 ? -26.39793 -9.44434  -62.38034 1.000 24.84620 ? 309 VAL   B C   1 
ATOM   4370 O  O   . VAL   B 1 309 ? -26.08968 -8.80523  -63.39545 1.000 22.01751 ? 309 VAL   B O   1 
ATOM   4371 C  CB  . VAL   B 1 309 ? -26.65680 -11.96109 -62.57215 1.000 25.11534 ? 309 VAL   B CB  1 
ATOM   4372 C  CG1 . VAL   B 1 309 ? -27.20227 -11.70827 -63.99019 1.000 16.79923 ? 309 VAL   B CG1 1 
ATOM   4373 C  CG2 . VAL   B 1 309 ? -25.88769 -13.26123 -62.52879 1.000 21.64463 ? 309 VAL   B CG2 1 
ATOM   4374 N  N   . LEU   B 1 310 ? -27.29724 -8.98576  -61.50391 1.000 21.23403 ? 310 LEU   B N   1 
ATOM   4375 C  CA  . LEU   B 1 310 ? -27.91154 -7.68186  -61.72203 1.000 21.10743 ? 310 LEU   B CA  1 
ATOM   4376 C  C   . LEU   B 1 310 ? -26.88700 -6.56419  -61.58700 1.000 18.25958 ? 310 LEU   B C   1 
ATOM   4377 O  O   . LEU   B 1 310 ? -26.95310 -5.56876  -62.31495 1.000 21.47833 ? 310 LEU   B O   1 
ATOM   4378 C  CB  . LEU   B 1 310 ? -29.07322 -7.46784  -60.75634 1.000 24.55025 ? 310 LEU   B CB  1 
ATOM   4379 C  CG  . LEU   B 1 310 ? -30.31548 -8.32027  -61.02193 1.000 25.96078 ? 310 LEU   B CG  1 
ATOM   4380 C  CD1 . LEU   B 1 310 ? -31.41693 -8.00117  -60.00595 1.000 25.72462 ? 310 LEU   B CD1 1 
ATOM   4381 C  CD2 . LEU   B 1 310 ? -30.80861 -8.10192  -62.43728 1.000 21.04530 ? 310 LEU   B CD2 1 
ATOM   4382 N  N   . GLN   B 1 311 ? -25.92845 -6.71914  -60.67387 1.000 17.91420 ? 311 GLN   B N   1 
ATOM   4383 C  CA  . GLN   B 1 311 ? -24.86207 -5.73348  -60.53947 1.000 25.03252 ? 311 GLN   B CA  1 
ATOM   4384 C  C   . GLN   B 1 311 ? -24.03064 -5.66155  -61.81618 1.000 23.21590 ? 311 GLN   B C   1 
ATOM   4385 O  O   . GLN   B 1 311 ? -23.75148 -4.57200  -62.32914 1.000 19.47229 ? 311 GLN   B O   1 
ATOM   4386 C  CB  . GLN   B 1 311 ? -23.97514 -6.06821  -59.33516 1.000 18.80681 ? 311 GLN   B CB  1 
ATOM   4387 C  CG  . GLN   B 1 311 ? -24.60483 -5.76033  -57.96726 1.000 18.92390 ? 311 GLN   B CG  1 
ATOM   4388 C  CD  . GLN   B 1 311 ? -23.79443 -6.35330  -56.82117 1.000 20.48654 ? 311 GLN   B CD  1 
ATOM   4389 O  OE1 . GLN   B 1 311 ? -23.28196 -7.47439  -56.92291 1.000 20.58306 ? 311 GLN   B OE1 1 
ATOM   4390 N  NE2 . GLN   B 1 311 ? -23.66784 -5.60407  -55.73091 1.000 18.06456 ? 311 GLN   B NE2 1 
ATOM   4391 N  N   . ASN   B 1 312 ? -23.63611 -6.81904  -62.35173 1.000 19.52669 ? 312 ASN   B N   1 
ATOM   4392 C  CA  . ASN   B 1 312 ? -22.83878 -6.81101  -63.56992 1.000 22.45640 ? 312 ASN   B CA  1 
ATOM   4393 C  C   . ASN   B 1 312 ? -23.66171 -6.36697  -64.77270 1.000 21.36646 ? 312 ASN   B C   1 
ATOM   4394 O  O   . ASN   B 1 312 ? -23.12056 -5.74890  -65.70113 1.000 23.05554 ? 312 ASN   B O   1 
ATOM   4395 C  CB  . ASN   B 1 312 ? -22.22037 -8.18861  -63.79726 1.000 19.35756 ? 312 ASN   B CB  1 
ATOM   4396 C  CG  . ASN   B 1 312 ? -21.00900 -8.41718  -62.92818 1.000 21.89716 ? 312 ASN   B CG  1 
ATOM   4397 O  OD1 . ASN   B 1 312 ? -19.89939 -8.04716  -63.29932 1.000 26.97363 ? 312 ASN   B OD1 1 
ATOM   4398 N  ND2 . ASN   B 1 312 ? -21.21063 -9.02054  -61.76093 1.000 25.24121 ? 312 ASN   B ND2 1 
ATOM   4399 N  N   . MET   B 1 313 ? -24.96779 -6.62869  -64.75169 1.000 16.47264 ? 313 MET   B N   1 
ATOM   4400 C  CA  . MET   B 1 313 ? -25.82831 -6.21506  -65.84881 1.000 20.05180 ? 313 MET   B CA  1 
ATOM   4401 C  C   . MET   B 1 313 ? -25.90961 -4.69238  -65.95468 1.000 22.47352 ? 313 MET   B C   1 
ATOM   4402 O  O   . MET   B 1 313 ? -25.74271 -4.12569  -67.04245 1.000 20.54389 ? 313 MET   B O   1 
ATOM   4403 C  CB  . MET   B 1 313 ? -27.21933 -6.81690  -65.67039 1.000 20.39556 ? 313 MET   B CB  1 
ATOM   4404 C  CG  . MET   B 1 313 ? -28.17161 -6.37646  -66.74324 1.000 20.07518 ? 313 MET   B CG  1 
ATOM   4405 S  SD  . MET   B 1 313 ? -29.81919 -7.02259  -66.50438 1.000 25.91666 ? 313 MET   B SD  1 
ATOM   4406 C  CE  . MET   B 1 313 ? -29.46938 -8.78557  -66.46820 1.000 18.57193 ? 313 MET   B CE  1 
ATOM   4407 N  N   . VAL   B 1 314 ? -26.19193 -4.01058  -64.84042 1.000 20.15580 ? 314 VAL   B N   1 
ATOM   4408 C  CA  . VAL   B 1 314 ? -26.23809 -2.55484  -64.88507 1.000 16.98216 ? 314 VAL   B CA  1 
ATOM   4409 C  C   . VAL   B 1 314 ? -24.83532 -1.99829  -65.11675 1.000 15.49485 ? 314 VAL   B C   1 
ATOM   4410 O  O   . VAL   B 1 314 ? -24.66688 -0.99286  -65.81280 1.000 18.67951 ? 314 VAL   B O   1 
ATOM   4411 C  CB  . VAL   B 1 314 ? -26.89041 -1.99779  -63.60191 1.000 17.63577 ? 314 VAL   B CB  1 
ATOM   4412 C  CG1 . VAL   B 1 314 ? -26.87664 -0.47339  -63.59587 1.000 12.81034 ? 314 VAL   B CG1 1 
ATOM   4413 C  CG2 . VAL   B 1 314 ? -28.31396 -2.47205  -63.50905 1.000 17.41121 ? 314 VAL   B CG2 1 
ATOM   4414 N  N   . HIS   B 1 315 ? -23.81212 -2.66669  -64.57886 1.000 17.88050 ? 315 HIS   B N   1 
ATOM   4415 C  CA  . HIS   B 1 315 ? -22.42667 -2.29917  -64.86614 1.000 17.95984 ? 315 HIS   B CA  1 
ATOM   4416 C  C   . HIS   B 1 315 ? -22.11599 -2.40446  -66.36041 1.000 17.26921 ? 315 HIS   B C   1 
ATOM   4417 O  O   . HIS   B 1 315 ? -21.45927 -1.51971  -66.92758 1.000 18.12418 ? 315 HIS   B O   1 
ATOM   4418 C  CB  . HIS   B 1 315 ? -21.48808 -3.18817  -64.04366 1.000 15.88238 ? 315 HIS   B CB  1 
ATOM   4419 C  CG  . HIS   B 1 315 ? -20.03140 -2.87669  -64.20811 1.000 15.15562 ? 315 HIS   B CG  1 
ATOM   4420 N  ND1 . HIS   B 1 315 ? -19.51210 -1.60538  -64.07024 1.000 16.79774 ? 315 HIS   B ND1 1 
ATOM   4421 C  CD2 . HIS   B 1 315 ? -18.97753 -3.68505  -64.47015 1.000 15.15835 ? 315 HIS   B CD2 1 
ATOM   4422 C  CE1 . HIS   B 1 315 ? -18.20421 -1.64388  -64.24969 1.000 15.51183 ? 315 HIS   B CE1 1 
ATOM   4423 N  NE2 . HIS   B 1 315 ? -17.85495 -2.89560  -64.49399 1.000 15.72276 ? 315 HIS   B NE2 1 
ATOM   4424 N  N   . CYS   B 1 316 ? -22.55756 -3.49243  -67.00495 1.000 17.04561 ? 316 CYS   B N   1 
ATOM   4425 C  CA  . CYS   B 1 316 ? -22.42232 -3.63139  -68.45739 1.000 18.70045 ? 316 CYS   B CA  1 
ATOM   4426 C  C   . CYS   B 1 316 ? -23.16259 -2.52138  -69.18496 1.000 17.31410 ? 316 CYS   B C   1 
ATOM   4427 O  O   . CYS   B 1 316 ? -22.64095 -1.93397  -70.13927 1.000 15.33916 ? 316 CYS   B O   1 
ATOM   4428 C  CB  . CYS   B 1 316 ? -22.95560 -4.99321  -68.91665 1.000 18.37242 ? 316 CYS   B CB  1 
ATOM   4429 S  SG  . CYS   B 1 316 ? -21.86950 -6.36170  -68.57657 1.000 20.12846 ? 316 CYS   B SG  1 
ATOM   4430 N  N   . ALA   B 1 317 ? -24.39919 -2.24001  -68.75788 1.000 16.64390 ? 317 ALA   B N   1 
ATOM   4431 C  CA  . ALA   B 1 317 ? -25.18512 -1.18908  -69.38544 1.000 17.10770 ? 317 ALA   B CA  1 
ATOM   4432 C  C   . ALA   B 1 317 ? -24.52149 0.17508   -69.20610 1.000 17.98831 ? 317 ALA   B C   1 
ATOM   4433 O  O   . ALA   B 1 317 ? -24.55090 1.01733   -70.11328 1.000 15.12502 ? 317 ALA   B O   1 
ATOM   4434 C  CB  . ALA   B 1 317 ? -26.60389 -1.19293  -68.80523 1.000 18.32266 ? 317 ALA   B CB  1 
ATOM   4435 N  N   . ASP   B 1 318 ? -23.92153 0.41012   -68.03764 1.000 17.84422 ? 318 ASP   B N   1 
ATOM   4436 C  CA  . ASP   B 1 318 ? -23.11674 1.61296   -67.83011 1.000 15.23597 ? 318 ASP   B CA  1 
ATOM   4437 C  C   . ASP   B 1 318 ? -21.92403 1.66151   -68.78571 1.000 16.40052 ? 318 ASP   B C   1 
ATOM   4438 O  O   . ASP   B 1 318 ? -21.52841 2.74278   -69.23669 1.000 17.12807 ? 318 ASP   B O   1 
ATOM   4439 C  CB  . ASP   B 1 318 ? -22.64111 1.64692   -66.37277 1.000 15.84022 ? 318 ASP   B CB  1 
ATOM   4440 C  CG  . ASP   B 1 318 ? -22.28567 3.05028   -65.88200 1.000 17.25218 ? 318 ASP   B CG  1 
ATOM   4441 O  OD1 . ASP   B 1 318 ? -22.94855 4.01933   -66.29969 1.000 12.82667 ? 318 ASP   B OD1 1 
ATOM   4442 O  OD2 . ASP   B 1 318 ? -21.36494 3.16841   -65.04393 1.000 16.58296 ? 318 ASP   B OD2 1 
ATOM   4443 N  N   . LEU   B 1 319 ? -21.32903 0.50712   -69.09213 1.000 15.22151 ? 319 LEU   B N   1 
ATOM   4444 C  CA  . LEU   B 1 319 ? -20.15503 0.42614   -69.95046 1.000 13.92812 ? 319 LEU   B CA  1 
ATOM   4445 C  C   . LEU   B 1 319 ? -20.49948 -0.11692  -71.33198 1.000 15.30827 ? 319 LEU   B C   1 
ATOM   4446 O  O   . LEU   B 1 319 ? -19.72114 -0.87202  -71.92163 1.000 16.74503 ? 319 LEU   B O   1 
ATOM   4447 C  CB  . LEU   B 1 319 ? -19.07626 -0.43555  -69.30717 1.000 13.43503 ? 319 LEU   B CB  1 
ATOM   4448 C  CG  . LEU   B 1 319 ? -18.52372 0.06438   -67.97536 1.000 19.35873 ? 319 LEU   B CG  1 
ATOM   4449 C  CD1 . LEU   B 1 319 ? -17.40053 -0.86185  -67.51523 1.000 15.49560 ? 319 LEU   B CD1 1 
ATOM   4450 C  CD2 . LEU   B 1 319 ? -18.04654 1.52186   -68.11351 1.000 17.18076 ? 319 LEU   B CD2 1 
ATOM   4451 N  N   . SER   B 1 320 ? -21.65370 0.26815   -71.85971 1.000 13.68955 ? 320 SER   B N   1 
ATOM   4452 C  CA  . SER   B 1 320 ? -22.12766 -0.27189  -73.12163 1.000 16.59635 ? 320 SER   B CA  1 
ATOM   4453 C  C   . SER   B 1 320 ? -21.92585 0.67402   -74.29864 1.000 20.04419 ? 320 SER   B C   1 
ATOM   4454 O  O   . SER   B 1 320 ? -22.23050 0.28154   -75.42894 1.000 16.53572 ? 320 SER   B O   1 
ATOM   4455 C  CB  . SER   B 1 320 ? -23.60844 -0.66111  -73.01991 1.000 14.29843 ? 320 SER   B CB  1 
ATOM   4456 O  OG  . SER   B 1 320 ? -24.46817 0.46218   -72.93101 1.000 16.11780 ? 320 SER   B OG  1 
ATOM   4457 N  N   . ASN   B 1 321 ? -21.39536 1.88707   -74.07950 1.000 16.83228 ? 321 ASN   B N   1 
ATOM   4458 C  CA  . ASN   B 1 321 ? -21.20800 2.81040   -75.20242 1.000 19.67409 ? 321 ASN   B CA  1 
ATOM   4459 C  C   . ASN   B 1 321 ? -20.38135 2.20459   -76.33310 1.000 15.13842 ? 321 ASN   B C   1 
ATOM   4460 O  O   . ASN   B 1 321 ? -20.79577 2.32869   -77.49635 1.000 18.58793 ? 321 ASN   B O   1 
ATOM   4461 C  CB  . ASN   B 1 321 ? -20.55112 4.13872   -74.77942 1.000 14.79875 ? 321 ASN   B CB  1 
ATOM   4462 C  CG  . ASN   B 1 321 ? -21.36748 4.95488   -73.77918 1.000 17.11673 ? 321 ASN   B CG  1 
ATOM   4463 O  OD1 . ASN   B 1 321 ? -20.79066 5.79728   -73.08885 1.000 14.11426 ? 321 ASN   B OD1 1 
ATOM   4464 N  ND2 . ASN   B 1 321 ? -22.69405 4.73516   -73.69784 1.000 15.38607 ? 321 ASN   B ND2 1 
ATOM   4465 N  N   . PRO   B 1 322 ? -19.22046 1.58109   -76.09191 1.000 17.59343 ? 322 PRO   B N   1 
ATOM   4466 C  CA  . PRO   B 1 322 ? -18.45122 1.00560   -77.21051 1.000 16.38569 ? 322 PRO   B CA  1 
ATOM   4467 C  C   . PRO   B 1 322 ? -19.09734 -0.19884  -77.89037 1.000 21.43195 ? 322 PRO   B C   1 
ATOM   4468 O  O   . PRO   B 1 322 ? -18.54923 -0.66783  -78.89832 1.000 22.34336 ? 322 PRO   B O   1 
ATOM   4469 C  CB  . PRO   B 1 322 ? -17.12257 0.59583   -76.54998 1.000 16.61353 ? 322 PRO   B CB  1 
ATOM   4470 C  CG  . PRO   B 1 322 ? -17.04728 1.39182   -75.29492 1.000 15.92232 ? 322 PRO   B CG  1 
ATOM   4471 C  CD  . PRO   B 1 322 ? -18.45689 1.49453   -74.83120 1.000 16.30130 ? 322 PRO   B CD  1 
ATOM   4472 N  N   . THR   B 1 323 ? -20.21883 -0.72564  -77.38130 1.000 19.21902 ? 323 THR   B N   1 
ATOM   4473 C  CA  . THR   B 1 323 ? -20.93200 -1.82243  -78.03113 1.000 21.33922 ? 323 THR   B CA  1 
ATOM   4474 C  C   . THR   B 1 323 ? -22.09915 -1.34057  -78.87916 1.000 19.41472 ? 323 THR   B C   1 
ATOM   4475 O  O   . THR   B 1 323 ? -22.77700 -2.16245  -79.50215 1.000 23.41854 ? 323 THR   B O   1 
ATOM   4476 C  CB  . THR   B 1 323 ? -21.46502 -2.83616  -76.99755 1.000 18.20006 ? 323 THR   B CB  1 
ATOM   4477 O  OG1 . THR   B 1 323 ? -22.68247 -2.33182  -76.42202 1.000 18.75806 ? 323 THR   B OG1 1 
ATOM   4478 C  CG2 . THR   B 1 323 ? -20.44710 -3.10127  -75.89816 1.000 14.34142 ? 323 THR   B CG2 1 
ATOM   4479 N  N   . LYS   B 1 324 ? -22.38388 -0.05208  -78.88753 1.000 19.85017 ? 324 LYS   B N   1 
ATOM   4480 C  CA  . LYS   B 1 324 ? -23.48062 0.48358   -79.67845 1.000 20.07023 ? 324 LYS   B CA  1 
ATOM   4481 C  C   . LYS   B 1 324 ? -23.00334 0.74116   -81.09673 1.000 21.35952 ? 324 LYS   B C   1 
ATOM   4482 O  O   . LYS   B 1 324 ? -21.79898 0.69029   -81.37488 1.000 22.38468 ? 324 LYS   B O   1 
ATOM   4483 C  CB  . LYS   B 1 324 ? -24.01336 1.75562   -79.02103 1.000 18.18917 ? 324 LYS   B CB  1 
ATOM   4484 C  CG  . LYS   B 1 324 ? -24.55509 1.54291   -77.59811 1.000 20.58726 ? 324 LYS   B CG  1 
ATOM   4485 C  CD  . LYS   B 1 324 ? -25.76762 0.56753   -77.58914 1.000 24.16697 ? 324 LYS   B CD  1 
ATOM   4486 C  CE  . LYS   B 1 324 ? -26.29973 0.31414   -76.16133 1.000 19.15173 ? 324 LYS   B CE  1 
ATOM   4487 N  NZ  . LYS   B 1 324 ? -26.90484 1.53685   -75.54884 1.000 16.87431 ? 324 LYS   B NZ  1 
ATOM   4488 N  N   . PRO   B 1 325 ? -23.92568 0.96648   -82.03775 1.000 21.61088 ? 325 PRO   B N   1 
ATOM   4489 C  CA  . PRO   B 1 325 ? -23.51368 1.42165   -83.37381 1.000 21.92664 ? 325 PRO   B CA  1 
ATOM   4490 C  C   . PRO   B 1 325 ? -22.57638 2.62152   -83.28492 1.000 25.55255 ? 325 PRO   B C   1 
ATOM   4491 O  O   . PRO   B 1 325 ? -22.74758 3.51268   -82.44423 1.000 20.85971 ? 325 PRO   B O   1 
ATOM   4492 C  CB  . PRO   B 1 325 ? -24.84000 1.78848   -84.04656 1.000 24.77586 ? 325 PRO   B CB  1 
ATOM   4493 C  CG  . PRO   B 1 325 ? -25.82570 0.86705   -83.42991 1.000 21.71143 ? 325 PRO   B CG  1 
ATOM   4494 C  CD  . PRO   B 1 325 ? -25.35932 0.62080   -81.99759 1.000 22.15847 ? 325 PRO   B CD  1 
ATOM   4495 N  N   . LEU   B 1 326 ? -21.59429 2.63426   -84.19285 1.000 20.56576 ? 326 LEU   B N   1 
ATOM   4496 C  CA  . LEU   B 1 326 ? -20.47300 3.56797   -84.11534 1.000 22.04280 ? 326 LEU   B CA  1 
ATOM   4497 C  C   . LEU   B 1 326 ? -20.92898 5.02090   -84.03085 1.000 21.91888 ? 326 LEU   B C   1 
ATOM   4498 O  O   . LEU   B 1 326 ? -20.33727 5.81650   -83.28966 1.000 20.28639 ? 326 LEU   B O   1 
ATOM   4499 C  CB  . LEU   B 1 326 ? -19.55193 3.36244   -85.32253 1.000 24.36895 ? 326 LEU   B CB  1 
ATOM   4500 C  CG  . LEU   B 1 326 ? -18.28159 4.21374   -85.43572 1.000 19.45157 ? 326 LEU   B CG  1 
ATOM   4501 C  CD1 . LEU   B 1 326 ? -17.39267 4.08276   -84.20914 1.000 16.24534 ? 326 LEU   B CD1 1 
ATOM   4502 C  CD2 . LEU   B 1 326 ? -17.50868 3.81068   -86.68276 1.000 22.10990 ? 326 LEU   B CD2 1 
ATOM   4503 N  N   . GLN   B 1 327 ? -21.95975 5.39994   -84.79486 1.000 20.21214 ? 327 GLN   B N   1 
ATOM   4504 C  CA  . GLN   B 1 327 ? -22.42849 6.78297   -84.72942 1.000 23.51500 ? 327 GLN   B CA  1 
ATOM   4505 C  C   . GLN   B 1 327 ? -22.87169 7.14687   -83.31916 1.000 26.17677 ? 327 GLN   B C   1 
ATOM   4506 O  O   . GLN   B 1 327 ? -22.68335 8.29068   -82.88318 1.000 23.46070 ? 327 GLN   B O   1 
ATOM   4507 C  CB  . GLN   B 1 327 ? -23.55884 7.02572   -85.74075 1.000 32.79366 ? 327 GLN   B CB  1 
ATOM   4508 C  CG  . GLN   B 1 327 ? -24.69260 5.99213   -85.71931 1.000 37.08726 ? 327 GLN   B CG  1 
ATOM   4509 C  CD  . GLN   B 1 327 ? -25.92560 6.45249   -84.94080 1.000 47.31678 ? 327 GLN   B CD  1 
ATOM   4510 O  OE1 . GLN   B 1 327 ? -25.91935 7.51909   -84.31021 1.000 50.67912 ? 327 GLN   B OE1 1 
ATOM   4511 N  NE2 . GLN   B 1 327 ? -26.98498 5.62524   -84.96050 1.000 45.64447 ? 327 GLN   B NE2 1 
ATOM   4512 N  N   . LEU   B 1 328 ? -23.44808 6.18669   -82.58810 1.000 23.51226 ? 328 LEU   B N   1 
ATOM   4513 C  CA  . LEU   B 1 328 ? -23.77312 6.41626   -81.18411 1.000 25.54916 ? 328 LEU   B CA  1 
ATOM   4514 C  C   . LEU   B 1 328 ? -22.50436 6.46131   -80.32733 1.000 21.02352 ? 328 LEU   B C   1 
ATOM   4515 O  O   . LEU   B 1 328 ? -22.28846 7.41665   -79.57179 1.000 20.39683 ? 328 LEU   B O   1 
ATOM   4516 C  CB  . LEU   B 1 328 ? -24.74006 5.33319   -80.69113 1.000 27.73481 ? 328 LEU   B CB  1 
ATOM   4517 C  CG  . LEU   B 1 328 ? -26.18579 5.38388   -81.20934 1.000 27.11408 ? 328 LEU   B CG  1 
ATOM   4518 C  CD1 . LEU   B 1 328 ? -26.96252 4.12714   -80.80424 1.000 29.31878 ? 328 LEU   B CD1 1 
ATOM   4519 C  CD2 . LEU   B 1 328 ? -26.89583 6.61412   -80.69745 1.000 28.46665 ? 328 LEU   B CD2 1 
ATOM   4520 N  N   . TYR   B 1 329 ? -21.65594 5.43694   -80.44248 1.000 16.75120 ? 329 TYR   B N   1 
ATOM   4521 C  CA  . TYR   B 1 329 ? -20.41951 5.36653   -79.66789 1.000 17.08524 ? 329 TYR   B CA  1 
ATOM   4522 C  C   . TYR   B 1 329 ? -19.58193 6.64314   -79.79594 1.000 20.64458 ? 329 TYR   B C   1 
ATOM   4523 O  O   . TYR   B 1 329 ? -19.09049 7.18301   -78.79285 1.000 18.22170 ? 329 TYR   B O   1 
ATOM   4524 C  CB  . TYR   B 1 329 ? -19.63492 4.13805   -80.12555 1.000 15.14167 ? 329 TYR   B CB  1 
ATOM   4525 C  CG  . TYR   B 1 329 ? -18.30308 3.87794   -79.45629 1.000 18.16332 ? 329 TYR   B CG  1 
ATOM   4526 C  CD1 . TYR   B 1 329 ? -17.98057 4.42392   -78.21226 1.000 17.80884 ? 329 TYR   B CD1 1 
ATOM   4527 C  CD2 . TYR   B 1 329 ? -17.36518 3.05881   -80.07608 1.000 17.88177 ? 329 TYR   B CD2 1 
ATOM   4528 C  CE1 . TYR   B 1 329 ? -16.74799 4.17327   -77.62898 1.000 15.85181 ? 329 TYR   B CE1 1 
ATOM   4529 C  CE2 . TYR   B 1 329 ? -16.14899 2.80250   -79.50136 1.000 15.23928 ? 329 TYR   B CE2 1 
ATOM   4530 C  CZ  . TYR   B 1 329 ? -15.84196 3.36518   -78.27977 1.000 15.82648 ? 329 TYR   B CZ  1 
ATOM   4531 O  OH  . TYR   B 1 329 ? -14.61485 3.09176   -77.72341 1.000 15.38655 ? 329 TYR   B OH  1 
ATOM   4532 N  N   . ARG   B 1 330 ? -19.41975 7.15282   -81.01744 1.000 19.71033 ? 330 ARG   B N   1 
ATOM   4533 C  CA  . ARG   B 1 330 ? -18.56122 8.31954   -81.21055 1.000 19.15742 ? 330 ARG   B CA  1 
ATOM   4534 C  C   . ARG   B 1 330 ? -19.09628 9.55488   -80.50562 1.000 17.52166 ? 330 ARG   B C   1 
ATOM   4535 O  O   . ARG   B 1 330 ? -18.31037 10.37115  -80.01797 1.000 18.38600 ? 330 ARG   B O   1 
ATOM   4536 C  CB  . ARG   B 1 330 ? -18.37955 8.59941   -82.69583 1.000 19.40009 ? 330 ARG   B CB  1 
ATOM   4537 C  CG  . ARG   B 1 330 ? -17.42563 7.62964   -83.33335 1.000 20.10849 ? 330 ARG   B CG  1 
ATOM   4538 C  CD  . ARG   B 1 330 ? -16.59510 8.35573   -84.35586 1.000 30.73119 ? 330 ARG   B CD  1 
ATOM   4539 N  NE  . ARG   B 1 330 ? -17.26755 8.35110   -85.62988 1.000 30.22043 ? 330 ARG   B NE  1 
ATOM   4540 C  CZ  . ARG   B 1 330 ? -16.94789 9.12464   -86.65988 1.000 34.86403 ? 330 ARG   B CZ  1 
ATOM   4541 N  NH1 . ARG   B 1 330 ? -15.95373 10.00162  -86.56795 1.000 24.71006 ? 330 ARG   B NH1 1 
ATOM   4542 N  NH2 . ARG   B 1 330 ? -17.63836 9.00867   -87.78757 1.000 27.38101 ? 330 ARG   B NH2 1 
ATOM   4543 N  N   . GLN   B 1 331 ? -20.41641 9.71833   -80.44488 1.000 16.87882 ? 331 GLN   B N   1 
ATOM   4544 C  CA  . GLN   B 1 331 ? -20.97514 10.82894  -79.67991 1.000 22.26850 ? 331 GLN   B CA  1 
ATOM   4545 C  C   . GLN   B 1 331 ? -20.80459 10.64488  -78.17659 1.000 19.54397 ? 331 GLN   B C   1 
ATOM   4546 O  O   . GLN   B 1 331 ? -20.54832 11.62695  -77.47290 1.000 18.99751 ? 331 GLN   B O   1 
ATOM   4547 C  CB  . GLN   B 1 331 ? -22.44349 11.00206  -80.01701 1.000 23.49623 ? 331 GLN   B CB  1 
ATOM   4548 C  CG  . GLN   B 1 331 ? -22.65592 11.26478  -81.48564 1.000 30.66878 ? 331 GLN   B CG  1 
ATOM   4549 C  CD  . GLN   B 1 331 ? -24.07849 11.61431  -81.78358 1.000 36.91741 ? 331 GLN   B CD  1 
ATOM   4550 O  OE1 . GLN   B 1 331 ? -24.73688 10.94779  -82.57722 1.000 45.54574 ? 331 GLN   B OE1 1 
ATOM   4551 N  NE2 . GLN   B 1 331 ? -24.58389 12.64252  -81.12242 1.000 31.40602 ? 331 GLN   B NE2 1 
ATOM   4552 N  N   . TRP   B 1 332 ? -20.95324 9.41421   -77.66211 1.000 18.58908 ? 332 TRP   B N   1 
ATOM   4553 C  CA  . TRP   B 1 332 ? -20.62288 9.17099   -76.25644 1.000 18.75456 ? 332 TRP   B CA  1 
ATOM   4554 C  C   . TRP   B 1 332 ? -19.17772 9.53499   -75.96395 1.000 15.50406 ? 332 TRP   B C   1 
ATOM   4555 O  O   . TRP   B 1 332 ? -18.87610 10.12072  -74.91821 1.000 17.84670 ? 332 TRP   B O   1 
ATOM   4556 C  CB  . TRP   B 1 332 ? -20.88590 7.70532   -75.87721 1.000 16.81811 ? 332 TRP   B CB  1 
ATOM   4557 C  CG  . TRP   B 1 332 ? -22.35258 7.42157   -75.80641 1.000 17.22579 ? 332 TRP   B CG  1 
ATOM   4558 C  CD1 . TRP   B 1 332 ? -23.04574 6.48781   -76.52769 1.000 17.88303 ? 332 TRP   B CD1 1 
ATOM   4559 C  CD2 . TRP   B 1 332 ? -23.32320 8.12022   -75.01207 1.000 16.32930 ? 332 TRP   B CD2 1 
ATOM   4560 N  NE1 . TRP   B 1 332 ? -24.38517 6.55484   -76.21479 1.000 20.26804 ? 332 TRP   B NE1 1 
ATOM   4561 C  CE2 . TRP   B 1 332 ? -24.58177 7.55010   -75.29412 1.000 16.18515 ? 332 TRP   B CE2 1 
ATOM   4562 C  CE3 . TRP   B 1 332 ? -23.24939 9.17425   -74.08189 1.000 16.30881 ? 332 TRP   B CE3 1 
ATOM   4563 C  CZ2 . TRP   B 1 332 ? -25.75029 7.98041   -74.67321 1.000 18.22373 ? 332 TRP   B CZ2 1 
ATOM   4564 C  CZ3 . TRP   B 1 332 ? -24.41491 9.60641   -73.47320 1.000 14.54734 ? 332 TRP   B CZ3 1 
ATOM   4565 C  CH2 . TRP   B 1 332 ? -25.65038 9.01221   -73.77555 1.000 18.23338 ? 332 TRP   B CH2 1 
ATOM   4566 N  N   . THR   B 1 333 ? -18.26826 9.19060   -76.87571 1.000 17.68806 ? 333 THR   B N   1 
ATOM   4567 C  CA  . THR   B 1 333 ? -16.85552 9.49427   -76.66830 1.000 16.66731 ? 333 THR   B CA  1 
ATOM   4568 C  C   . THR   B 1 333 ? -16.61157 11.00137  -76.62827 1.000 16.99381 ? 333 THR   B C   1 
ATOM   4569 O  O   . THR   B 1 333 ? -15.87615 11.49419  -75.76256 1.000 16.50749 ? 333 THR   B O   1 
ATOM   4570 C  CB  . THR   B 1 333 ? -16.02292 8.83087   -77.76470 1.000 16.36827 ? 333 THR   B CB  1 
ATOM   4571 O  OG1 . THR   B 1 333 ? -16.15129 7.40921   -77.65765 1.000 16.17329 ? 333 THR   B OG1 1 
ATOM   4572 C  CG2 . THR   B 1 333 ? -14.56473 9.19653   -77.63410 1.000 15.77799 ? 333 THR   B CG2 1 
ATOM   4573 N  N   . ASP   B 1 334 ? -17.22250 11.74836  -77.55283 1.000 19.40833 ? 334 ASP   B N   1 
ATOM   4574 C  CA  . ASP   B 1 334 ? -17.08174 13.20144  -77.53869 1.000 19.66628 ? 334 ASP   B CA  1 
ATOM   4575 C  C   . ASP   B 1 334 ? -17.55123 13.79042  -76.21743 1.000 19.54517 ? 334 ASP   B C   1 
ATOM   4576 O  O   . ASP   B 1 334 ? -16.92126 14.71091  -75.67979 1.000 18.31143 ? 334 ASP   B O   1 
ATOM   4577 C  CB  . ASP   B 1 334 ? -17.86963 13.82373  -78.68908 1.000 20.81064 ? 334 ASP   B CB  1 
ATOM   4578 C  CG  . ASP   B 1 334 ? -17.23387 13.56105  -80.04448 1.000 28.35258 ? 334 ASP   B CG  1 
ATOM   4579 O  OD1 . ASP   B 1 334 ? -16.02440 13.21743  -80.09905 1.000 26.79671 ? 334 ASP   B OD1 1 
ATOM   4580 O  OD2 . ASP   B 1 334 ? -17.95410 13.71518  -81.05394 1.000 24.14310 ? 334 ASP   B OD2 1 
ATOM   4581 N  N   . ARG   B 1 335 ? -18.65788 13.27426  -75.68057 1.000 16.39345 ? 335 ARG   B N   1 
ATOM   4582 C  CA  . ARG   B 1 335 ? -19.19389 13.81571  -74.43220 1.000 18.31370 ? 335 ARG   B CA  1 
ATOM   4583 C  C   . ARG   B 1 335 ? -18.30497 13.48741  -73.22874 1.000 17.33710 ? 335 ARG   B C   1 
ATOM   4584 O  O   . ARG   B 1 335 ? -18.04388 14.36704  -72.39691 1.000 15.84505 ? 335 ARG   B O   1 
ATOM   4585 C  CB  . ARG   B 1 335 ? -20.62423 13.31528  -74.22626 1.000 16.54281 ? 335 ARG   B CB  1 
ATOM   4586 C  CG  . ARG   B 1 335 ? -21.61791 13.94027  -75.21519 1.000 16.59913 ? 335 ARG   B CG  1 
ATOM   4587 C  CD  . ARG   B 1 335 ? -22.96093 13.23601  -75.19989 1.000 19.19680 ? 335 ARG   B CD  1 
ATOM   4588 N  NE  . ARG   B 1 335 ? -23.95424 13.95616  -75.99772 1.000 19.65865 ? 335 ARG   B NE  1 
ATOM   4589 C  CZ  . ARG   B 1 335 ? -24.69176 14.95173  -75.52841 1.000 22.13724 ? 335 ARG   B CZ  1 
ATOM   4590 N  NH1 . ARG   B 1 335 ? -24.54007 15.34614  -74.26928 1.000 23.25810 ? 335 ARG   B NH1 1 
ATOM   4591 N  NH2 . ARG   B 1 335 ? -25.57459 15.55413  -76.31209 1.000 23.26066 ? 335 ARG   B NH2 1 
ATOM   4592 N  N   . ILE   B 1 336 ? -17.82138 12.24365  -73.10796 1.000 15.47852 ? 336 ILE   B N   1 
ATOM   4593 C  CA  . ILE   B 1 336 ? -16.99389 11.92465  -71.94223 1.000 18.67238 ? 336 ILE   B CA  1 
ATOM   4594 C  C   . ILE   B 1 336 ? -15.66223 12.67306  -72.00466 1.000 16.19515 ? 336 ILE   B C   1 
ATOM   4595 O  O   . ILE   B 1 336 ? -15.14584 13.12015  -70.97691 1.000 18.38784 ? 336 ILE   B O   1 
ATOM   4596 C  CB  . ILE   B 1 336 ? -16.78858 10.40213  -71.77296 1.000 14.72192 ? 336 ILE   B CB  1 
ATOM   4597 C  CG1 . ILE   B 1 336 ? -16.18478 10.09941  -70.38633 1.000 16.80131 ? 336 ILE   B CG1 1 
ATOM   4598 C  CG2 . ILE   B 1 336 ? -15.86572 9.81841   -72.82292 1.000 17.42014 ? 336 ILE   B CG2 1 
ATOM   4599 C  CD1 . ILE   B 1 336 ? -17.14666 10.28264  -69.21100 1.000 16.50201 ? 336 ILE   B CD1 1 
ATOM   4600 N  N   . MET   B 1 337 ? -15.09017 12.83517  -73.20167 1.000 17.21669 ? 337 MET   B N   1 
ATOM   4601 C  CA  . MET   B 1 337 ? -13.84849 13.60083  -73.31664 1.000 18.13060 ? 337 MET   B CA  1 
ATOM   4602 C  C   . MET   B 1 337 ? -14.07050 15.07366  -72.99882 1.000 18.52995 ? 337 MET   B C   1 
ATOM   4603 O  O   . MET   B 1 337 ? -13.20146 15.72228  -72.40270 1.000 20.03777 ? 337 MET   B O   1 
ATOM   4604 C  CB  . MET   B 1 337 ? -13.25705 13.43819  -74.71762 1.000 20.04384 ? 337 MET   B CB  1 
ATOM   4605 C  CG  . MET   B 1 337 ? -12.79433 12.02106  -75.02083 1.000 18.61989 ? 337 MET   B CG  1 
ATOM   4606 S  SD  . MET   B 1 337 ? -11.75141 11.28476  -73.73096 1.000 20.98099 ? 337 MET   B SD  1 
ATOM   4607 C  CE  . MET   B 1 337 ? -10.37373 12.43990  -73.64813 1.000 26.19930 ? 337 MET   B CE  1 
ATOM   4608 N  N   . GLU   B 1 338 ? -15.22751 15.61200  -73.37948 1.000 18.12178 ? 338 GLU   B N   1 
ATOM   4609 C  CA  . GLU   B 1 338 ? -15.57433 16.97426  -72.99657 1.000 20.90834 ? 338 GLU   B CA  1 
ATOM   4610 C  C   . GLU   B 1 338 ? -15.67227 17.10704  -71.48366 1.000 25.28174 ? 338 GLU   B C   1 
ATOM   4611 O  O   . GLU   B 1 338 ? -15.24855 18.11579  -70.90696 1.000 20.01592 ? 338 GLU   B O   1 
ATOM   4612 C  CB  . GLU   B 1 338 ? -16.89261 17.36703  -73.66207 1.000 21.38114 ? 338 GLU   B CB  1 
ATOM   4613 C  CG  . GLU   B 1 338 ? -17.41541 18.73915  -73.29919 1.000 31.90068 ? 338 GLU   B CG  1 
ATOM   4614 C  CD  . GLU   B 1 338 ? -18.44986 19.24162  -74.30407 1.000 40.98188 ? 338 GLU   B CD  1 
ATOM   4615 O  OE1 . GLU   B 1 338 ? -18.69900 18.55506  -75.32159 1.000 50.03531 ? 338 GLU   B OE1 1 
ATOM   4616 O  OE2 . GLU   B 1 338 ? -19.03147 20.31616  -74.07157 1.000 44.56520 ? 338 GLU   B OE2 1 
ATOM   4617 N  N   . GLU   B 1 339 ? -16.22847 16.09160  -70.82186 1.000 21.11795 ? 339 GLU   B N   1 
ATOM   4618 C  CA  . GLU   B 1 339 ? -16.37327 16.14520  -69.37537 1.000 22.07976 ? 339 GLU   B CA  1 
ATOM   4619 C  C   . GLU   B 1 339 ? -15.02158 16.00229  -68.68164 1.000 18.90721 ? 339 GLU   B C   1 
ATOM   4620 O  O   . GLU   B 1 339 ? -14.72222 16.74323  -67.73739 1.000 24.18165 ? 339 GLU   B O   1 
ATOM   4621 C  CB  . GLU   B 1 339 ? -17.35373 15.06351  -68.91933 1.000 22.37806 ? 339 GLU   B CB  1 
ATOM   4622 C  CG  . GLU   B 1 339 ? -17.74168 15.18116  -67.48009 1.000 16.96340 ? 339 GLU   B CG  1 
ATOM   4623 C  CD  . GLU   B 1 339 ? -18.89062 14.27190  -67.11096 1.000 17.16455 ? 339 GLU   B CD  1 
ATOM   4624 O  OE1 . GLU   B 1 339 ? -19.93273 14.29458  -67.80684 1.000 17.71995 ? 339 GLU   B OE1 1 
ATOM   4625 O  OE2 . GLU   B 1 339 ? -18.74867 13.53572  -66.11136 1.000 15.64520 ? 339 GLU   B OE2 1 
ATOM   4626 N  N   . PHE   B 1 340 ? -14.18151 15.08401  -69.16058 1.000 16.28930 ? 340 PHE   B N   1 
ATOM   4627 C  CA  . PHE   B 1 340 ? -12.82888 14.93362  -68.63464 1.000 17.36989 ? 340 PHE   B CA  1 
ATOM   4628 C  C   . PHE   B 1 340 ? -12.01764 16.22465  -68.78434 1.000 27.55476 ? 340 PHE   B C   1 
ATOM   4629 O  O   . PHE   B 1 340 ? -11.35269 16.66810  -67.84060 1.000 24.41142 ? 340 PHE   B O   1 
ATOM   4630 C  CB  . PHE   B 1 340 ? -12.12068 13.78674  -69.35336 1.000 21.33716 ? 340 PHE   B CB  1 
ATOM   4631 C  CG  . PHE   B 1 340 ? -12.46920 12.42924  -68.83707 1.000 25.04539 ? 340 PHE   B CG  1 
ATOM   4632 C  CD1 . PHE   B 1 340 ? -13.58815 12.23338  -68.03491 1.000 23.78750 ? 340 PHE   B CD1 1 
ATOM   4633 C  CD2 . PHE   B 1 340 ? -11.66024 11.34030  -69.13875 1.000 29.90472 ? 340 PHE   B CD2 1 
ATOM   4634 C  CE1 . PHE   B 1 340 ? -13.89368 10.97174  -67.55255 1.000 25.13887 ? 340 PHE   B CE1 1 
ATOM   4635 C  CE2 . PHE   B 1 340 ? -11.96653 10.07460  -68.65923 1.000 26.20316 ? 340 PHE   B CE2 1 
ATOM   4636 C  CZ  . PHE   B 1 340 ? -13.07734 9.89042   -67.87032 1.000 22.83026 ? 340 PHE   B CZ  1 
ATOM   4637 N  N   . PHE   B 1 341 ? -12.05625 16.83406  -69.97338 1.000 21.39825 ? 341 PHE   B N   1 
ATOM   4638 C  CA  . PHE   B 1 341 ? -11.28101 18.04820  -70.22679 1.000 24.60542 ? 341 PHE   B CA  1 
ATOM   4639 C  C   . PHE   B 1 341 ? -11.76219 19.20802  -69.35815 1.000 24.40541 ? 341 PHE   B C   1 
ATOM   4640 O  O   . PHE   B 1 341 ? -10.96008 20.02331  -68.89215 1.000 26.38255 ? 341 PHE   B O   1 
ATOM   4641 C  CB  . PHE   B 1 341 ? -11.36541 18.42774  -71.71343 1.000 26.83971 ? 341 PHE   B CB  1 
ATOM   4642 C  CG  . PHE   B 1 341 ? -10.66544 17.46076  -72.64403 1.000 22.10728 ? 341 PHE   B CG  1 
ATOM   4643 C  CD1 . PHE   B 1 341 ? -9.67975  16.60357  -72.17931 1.000 23.37301 ? 341 PHE   B CD1 1 
ATOM   4644 C  CD2 . PHE   B 1 341 ? -10.98153 17.43641  -73.99516 1.000 21.98194 ? 341 PHE   B CD2 1 
ATOM   4645 C  CE1 . PHE   B 1 341 ? -9.03706  15.71782  -73.03740 1.000 24.64586 ? 341 PHE   B CE1 1 
ATOM   4646 C  CE2 . PHE   B 1 341 ? -10.34096 16.55981  -74.86144 1.000 20.54740 ? 341 PHE   B CE2 1 
ATOM   4647 C  CZ  . PHE   B 1 341 ? -9.36939  15.69769  -74.38316 1.000 21.34677 ? 341 PHE   B CZ  1 
ATOM   4648 N  N   . ARG   B 1 342 ? -13.06713 19.30580  -69.13048 1.000 25.12859 ? 342 ARG   B N   1 
ATOM   4649 C  CA  . ARG   B 1 342 ? -13.55232 20.32781  -68.21492 1.000 24.13788 ? 342 ARG   B CA  1 
ATOM   4650 C  C   . ARG   B 1 342 ? -13.10098 20.05634  -66.78477 1.000 28.83438 ? 342 ARG   B C   1 
ATOM   4651 O  O   . ARG   B 1 342 ? -12.89839 21.00542  -66.01986 1.000 27.20110 ? 342 ARG   B O   1 
ATOM   4652 C  CB  . ARG   B 1 342 ? -15.06998 20.43787  -68.29921 1.000 25.96580 ? 342 ARG   B CB  1 
ATOM   4653 C  CG  . ARG   B 1 342 ? -15.55175 21.05878  -69.59903 1.000 35.79633 ? 342 ARG   B CG  1 
ATOM   4654 C  CD  . ARG   B 1 342 ? -16.99724 20.71943  -69.86351 1.000 45.31197 ? 342 ARG   B CD  1 
ATOM   4655 N  NE  . ARG   B 1 342 ? -17.47531 21.36470  -71.07852 1.000 59.76590 ? 342 ARG   B NE  1 
ATOM   4656 C  CZ  . ARG   B 1 342 ? -18.75559 21.46086  -71.42199 1.000 60.11383 ? 342 ARG   B CZ  1 
ATOM   4657 N  NH1 . ARG   B 1 342 ? -19.69918 20.94524  -70.64400 1.000 53.70553 ? 342 ARG   B NH1 1 
ATOM   4658 N  NH2 . ARG   B 1 342 ? -19.09293 22.07479  -72.54932 1.000 63.10923 ? 342 ARG   B NH2 1 
ATOM   4659 N  N   . GLN   B 1 343 ? -12.90485 18.78549  -66.40729 1.000 26.22739 ? 343 GLN   B N   1 
ATOM   4660 C  CA  . GLN   B 1 343 ? -12.34062 18.50397  -65.08728 1.000 29.30843 ? 343 GLN   B CA  1 
ATOM   4661 C  C   . GLN   B 1 343 ? -10.87212 18.89616  -65.03216 1.000 29.73526 ? 343 GLN   B C   1 
ATOM   4662 O  O   . GLN   B 1 343 ? -10.42721 19.53215  -64.06966 1.000 30.92910 ? 343 GLN   B O   1 
ATOM   4663 C  CB  . GLN   B 1 343 ? -12.49122 17.02642  -64.70412 1.000 22.94280 ? 343 GLN   B CB  1 
ATOM   4664 C  CG  . GLN   B 1 343 ? -11.72548 16.66968  -63.40916 1.000 23.84054 ? 343 GLN   B CG  1 
ATOM   4665 C  CD  . GLN   B 1 343 ? -11.95890 15.23856  -62.91243 1.000 21.44377 ? 343 GLN   B CD  1 
ATOM   4666 O  OE1 . GLN   B 1 343 ? -13.05764 14.69827  -63.01016 1.000 18.47019 ? 343 GLN   B OE1 1 
ATOM   4667 N  NE2 . GLN   B 1 343 ? -10.91331 14.62499  -62.38633 1.000 20.59160 ? 343 GLN   B NE2 1 
ATOM   4668 N  N   . GLY   B 1 344 ? -10.10123 18.49988  -66.04763 1.000 28.69104 ? 344 GLY   B N   1 
ATOM   4669 C  CA  . GLY   B 1 344 ? -8.68769  18.84084  -66.08419 1.000 32.12001 ? 344 GLY   B CA  1 
ATOM   4670 C  C   . GLY   B 1 344 ? -8.42731  20.33567  -66.14172 1.000 35.65353 ? 344 GLY   B C   1 
ATOM   4671 O  O   . GLY   B 1 344 ? -7.37487  20.79843  -65.69418 1.000 35.14231 ? 344 GLY   B O   1 
ATOM   4672 N  N   . ASP   B 1 345 ? -9.37405  21.10775  -66.69929 1.000 37.35932 ? 345 ASP   B N   1 
ATOM   4673 C  CA  . ASP   B 1 345 ? -9.27528  22.56553  -66.66352 1.000 33.12891 ? 345 ASP   B CA  1 
ATOM   4674 C  C   . ASP   B 1 345 ? -9.47984  23.09430  -65.24689 1.000 44.00317 ? 345 ASP   B C   1 
ATOM   4675 O  O   . ASP   B 1 345 ? -8.80136  24.04108  -64.82785 1.000 45.62501 ? 345 ASP   B O   1 
ATOM   4676 C  CB  . ASP   B 1 345 ? -10.29755 23.20391  -67.61091 1.000 32.27951 ? 345 ASP   B CB  1 
ATOM   4677 C  CG  . ASP   B 1 345 ? -9.94674  23.01661  -69.08450 1.000 32.23164 ? 345 ASP   B CG  1 
ATOM   4678 O  OD1 . ASP   B 1 345 ? -8.86445  22.47232  -69.39315 1.000 32.72963 ? 345 ASP   B OD1 1 
ATOM   4679 O  OD2 . ASP   B 1 345 ? -10.77165 23.41043  -69.93238 1.000 31.33928 ? 345 ASP   B OD2 1 
ATOM   4680 N  N   . ARG   B 1 346 ? -10.42426 22.51302  -64.49793 1.000 40.53745 ? 346 ARG   B N   1 
ATOM   4681 C  CA  . ARG   B 1 346 ? -10.58169 22.91329  -63.10255 1.000 41.99965 ? 346 ARG   B CA  1 
ATOM   4682 C  C   . ARG   B 1 346 ? -9.39076  22.46464  -62.26121 1.000 40.21742 ? 346 ARG   B C   1 
ATOM   4683 O  O   . ARG   B 1 346 ? -9.00206  23.16602  -61.31773 1.000 41.94158 ? 346 ARG   B O   1 
ATOM   4684 C  CB  . ARG   B 1 346 ? -11.89532 22.37085  -62.53753 1.000 35.09163 ? 346 ARG   B CB  1 
ATOM   4685 C  CG  . ARG   B 1 346 ? -13.10600 22.88717  -63.29955 1.000 45.50684 ? 346 ARG   B CG  1 
ATOM   4686 C  CD  . ARG   B 1 346 ? -14.35491 23.00292  -62.43860 1.000 44.94690 ? 346 ARG   B CD  1 
ATOM   4687 N  NE  . ARG   B 1 346 ? -15.01848 21.71574  -62.28331 1.000 51.96301 ? 346 ARG   B NE  1 
ATOM   4688 C  CZ  . ARG   B 1 346 ? -15.54316 21.27624  -61.14422 1.000 49.38673 ? 346 ARG   B CZ  1 
ATOM   4689 N  NH1 . ARG   B 1 346 ? -15.49255 22.02782  -60.04938 1.000 46.23576 ? 346 ARG   B NH1 1 
ATOM   4690 N  NH2 . ARG   B 1 346 ? -16.12665 20.08571  -61.10465 1.000 50.19618 ? 346 ARG   B NH2 1 
ATOM   4691 N  N   . GLU   B 1 347 ? -8.78225  21.32642  -62.60392 1.000 29.17302 ? 347 GLU   B N   1 
ATOM   4692 C  CA  . GLU   B 1 347 ? -7.56780  20.89832  -61.91537 1.000 34.57432 ? 347 GLU   B CA  1 
ATOM   4693 C  C   . GLU   B 1 347 ? -6.40244  21.82804  -62.23446 1.000 43.46725 ? 347 GLU   B C   1 
ATOM   4694 O  O   . GLU   B 1 347 ? -5.60488  22.16126  -61.35009 1.000 43.32606 ? 347 GLU   B O   1 
ATOM   4695 C  CB  . GLU   B 1 347 ? -7.22375  19.45356  -62.29812 1.000 32.39628 ? 347 GLU   B CB  1 
ATOM   4696 C  CG  . GLU   B 1 347 ? -8.21986  18.41800  -61.76468 1.000 33.39383 ? 347 GLU   B CG  1 
ATOM   4697 C  CD  . GLU   B 1 347 ? -8.08648  17.04843  -62.40912 1.000 34.01776 ? 347 GLU   B CD  1 
ATOM   4698 O  OE1 . GLU   B 1 347 ? -7.52767  16.94435  -63.52429 1.000 36.26094 ? 347 GLU   B OE1 1 
ATOM   4699 O  OE2 . GLU   B 1 347 ? -8.54409  16.06561  -61.79167 1.000 30.45813 ? 347 GLU   B OE2 1 
ATOM   4700 N  N   . ARG   B 1 348 ? -6.28801  22.25688  -63.49425 1.000 39.77646 ? 348 ARG   B N   1 
ATOM   4701 C  CA  . ARG   B 1 348 ? -5.21522  23.17196  -63.87362 1.000 46.40183 ? 348 ARG   B CA  1 
ATOM   4702 C  C   . ARG   B 1 348 ? -5.38198  24.51868  -63.17675 1.000 46.28618 ? 348 ARG   B C   1 
ATOM   4703 O  O   . ARG   B 1 348 ? -4.43663  25.03736  -62.57133 1.000 46.65669 ? 348 ARG   B O   1 
ATOM   4704 C  CB  . ARG   B 1 348 ? -5.18735  23.34323  -65.39766 1.000 46.54452 ? 348 ARG   B CB  1 
ATOM   4705 C  CG  . ARG   B 1 348 ? -3.79314  23.46250  -66.01382 1.000 44.62935 ? 348 ARG   B CG  1 
ATOM   4706 C  CD  . ARG   B 1 348 ? -3.88564  23.85209  -67.48753 1.000 44.46538 ? 348 ARG   B CD  1 
ATOM   4707 N  NE  . ARG   B 1 348 ? -4.04306  22.69829  -68.37949 1.000 51.93266 ? 348 ARG   B NE  1 
ATOM   4708 C  CZ  . ARG   B 1 348 ? -5.19390  22.33176  -68.94612 1.000 45.70380 ? 348 ARG   B CZ  1 
ATOM   4709 N  NH1 . ARG   B 1 348 ? -6.30765  23.02132  -68.71882 1.000 38.48553 ? 348 ARG   B NH1 1 
ATOM   4710 N  NH2 . ARG   B 1 348 ? -5.23100  21.27535  -69.74795 1.000 40.77282 ? 348 ARG   B NH2 1 
ATOM   4711 N  N   . GLU   B 1 349 ? -6.58537  25.09881  -63.26324 1.000 44.34971 ? 349 GLU   B N   1 
ATOM   4712 C  CA  . GLU   B 1 349 ? -6.93070  26.31786  -62.53653 1.000 45.40495 ? 349 GLU   B CA  1 
ATOM   4713 C  C   . GLU   B 1 349 ? -6.42407  26.30867  -61.10031 1.000 48.71634 ? 349 GLU   B C   1 
ATOM   4714 O  O   . GLU   B 1 349 ? -5.79197  27.26455  -60.63874 1.000 48.91642 ? 349 GLU   B O   1 
ATOM   4715 C  CB  . GLU   B 1 349 ? -8.44791  26.48686  -62.52408 1.000 47.46447 ? 349 GLU   B CB  1 
ATOM   4716 C  CG  . GLU   B 1 349 ? -9.02554  27.33781  -63.61692 1.000 52.35557 ? 349 GLU   B CG  1 
ATOM   4717 C  CD  . GLU   B 1 349 ? -10.44701 27.73877  -63.28968 1.000 56.07201 ? 349 GLU   B CD  1 
ATOM   4718 O  OE1 . GLU   B 1 349 ? -10.76276 28.94704  -63.36364 1.000 62.72239 ? 349 GLU   B OE1 1 
ATOM   4719 O  OE2 . GLU   B 1 349 ? -11.23973 26.84154  -62.92534 1.000 50.21707 ? 349 GLU   B OE2 1 
ATOM   4720 N  N   . ARG   B 1 350 ? -6.72228  25.23451  -60.37563 1.000 45.35346 ? 350 ARG   B N   1 
ATOM   4721 C  CA  . ARG   B 1 350 ? -6.37100  25.07200  -58.97270 1.000 44.37057 ? 350 ARG   B CA  1 
ATOM   4722 C  C   . ARG   B 1 350 ? -4.91401  24.69949  -58.76962 1.000 42.80992 ? 350 ARG   B C   1 
ATOM   4723 O  O   . ARG   B 1 350 ? -4.49291  24.51454  -57.62198 1.000 44.53388 ? 350 ARG   B O   1 
ATOM   4724 C  CB  . ARG   B 1 350 ? -7.24971  23.99402  -58.34729 1.000 43.03608 ? 350 ARG   B CB  1 
ATOM   4725 C  CG  . ARG   B 1 350 ? -8.74487  24.25620  -58.43729 1.000 44.20631 ? 350 ARG   B CG  1 
ATOM   4726 C  CD  . ARG   B 1 350 ? -9.49052  23.02460  -57.98167 1.000 50.43042 ? 350 ARG   B CD  1 
ATOM   4727 N  NE  . ARG   B 1 350 ? -10.53786 23.31070  -57.00847 1.000 50.21923 ? 350 ARG   B NE  1 
ATOM   4728 C  CZ  . ARG   B 1 350 ? -10.46490 23.01047  -55.71125 1.000 46.02599 ? 350 ARG   B CZ  1 
ATOM   4729 N  NH1 . ARG   B 1 350 ? -9.36940  22.42322  -55.21557 1.000 47.28799 ? 350 ARG   B NH1 1 
ATOM   4730 N  NH2 . ARG   B 1 350 ? -11.47388 23.31152  -54.91187 1.000 50.85553 ? 350 ARG   B NH2 1 
ATOM   4731 N  N   . GLY   B 1 351 ? -4.14583  24.56401  -59.84359 1.000 38.28696 ? 351 GLY   B N   1 
ATOM   4732 C  CA  . GLY   B 1 351 ? -2.82100  23.98485  -59.70822 1.000 44.17375 ? 351 GLY   B CA  1 
ATOM   4733 C  C   . GLY   B 1 351 ? -2.80916  22.58668  -59.12745 1.000 40.96793 ? 351 GLY   B C   1 
ATOM   4734 O  O   . GLY   B 1 351 ? -1.87612  22.22315  -58.40140 1.000 39.80585 ? 351 GLY   B O   1 
ATOM   4735 N  N   . MET   B 1 352 ? -3.83230  21.79738  -59.41708 1.000 42.48756 ? 352 MET   B N   1 
ATOM   4736 C  CA  . MET   B 1 352 ? -3.83744  20.39088  -59.05016 1.000 41.47337 ? 352 MET   B CA  1 
ATOM   4737 C  C   . MET   B 1 352 ? -3.21672  19.56788  -60.16479 1.000 43.46855 ? 352 MET   B C   1 
ATOM   4738 O  O   . MET   B 1 352 ? -3.18191  19.98401  -61.32892 1.000 37.71479 ? 352 MET   B O   1 
ATOM   4739 C  CB  . MET   B 1 352 ? -5.25851  19.90253  -58.78342 1.000 41.81951 ? 352 MET   B CB  1 
ATOM   4740 C  CG  . MET   B 1 352 ? -6.02543  20.69344  -57.74378 1.000 38.32160 ? 352 MET   B CG  1 
ATOM   4741 S  SD  . MET   B 1 352 ? -7.76160  20.18677  -57.75076 1.000 38.94836 ? 352 MET   B SD  1 
ATOM   4742 C  CE  . MET   B 1 352 ? -7.57821  18.40174  -57.59786 1.000 31.61216 ? 352 MET   B CE  1 
ATOM   4743 N  N   . GLU   B 1 353 ? -2.73775  18.38164  -59.80502 1.000 40.33851 ? 353 GLU   B N   1 
ATOM   4744 C  CA  . GLU   B 1 353 ? -2.22809  17.48731  -60.82971 1.000 43.70896 ? 353 GLU   B CA  1 
ATOM   4745 C  C   . GLU   B 1 353 ? -3.36687  17.01016  -61.73024 1.000 50.22197 ? 353 GLU   B C   1 
ATOM   4746 O  O   . GLU   B 1 353 ? -4.43017  16.60769  -61.24597 1.000 45.11597 ? 353 GLU   B O   1 
ATOM   4747 C  CB  . GLU   B 1 353 ? -1.53293  16.27801  -60.18817 1.000 45.95971 ? 353 GLU   B CB  1 
ATOM   4748 C  CG  . GLU   B 1 353 ? -1.63806  15.04855  -61.07080 1.000 54.72247 ? 353 GLU   B CG  1 
ATOM   4749 C  CD  . GLU   B 1 353 ? -0.79881  13.89317  -60.57370 1.000 56.32209 ? 353 GLU   B CD  1 
ATOM   4750 O  OE1 . GLU   B 1 353 ? -0.94476  13.50499  -59.39695 1.000 52.86939 ? 353 GLU   B OE1 1 
ATOM   4751 O  OE2 . GLU   B 1 353 ? -0.00329  13.35078  -61.37222 1.000 61.33314 ? 353 GLU   B OE2 1 
ATOM   4752 N  N   . ILE   B 1 354 ? -3.15137  17.07820  -63.03849 1.000 45.69731 ? 354 ILE   B N   1 
ATOM   4753 C  CA  . ILE   B 1 354 ? -4.20327  16.77753  -64.00425 1.000 42.69239 ? 354 ILE   B CA  1 
ATOM   4754 C  C   . ILE   B 1 354 ? -4.39718  15.26578  -64.08953 1.000 43.64904 ? 354 ILE   B C   1 
ATOM   4755 O  O   . ILE   B 1 354 ? -3.43000  14.51183  -64.24958 1.000 43.55009 ? 354 ILE   B O   1 
ATOM   4756 C  CB  . ILE   B 1 354 ? -3.86890  17.39248  -65.37359 1.000 41.78573 ? 354 ILE   B CB  1 
ATOM   4757 C  CG1 . ILE   B 1 354 ? -3.76296  18.91749  -65.22644 1.000 44.07477 ? 354 ILE   B CG1 1 
ATOM   4758 C  CG2 . ILE   B 1 354 ? -4.92370  17.02052  -66.41114 1.000 39.87409 ? 354 ILE   B CG2 1 
ATOM   4759 C  CD1 . ILE   B 1 354 ? -3.48141  19.66084  -66.50636 1.000 40.51012 ? 354 ILE   B CD1 1 
ATOM   4760 N  N   . SER   B 1 355 ? -5.65554  14.81456  -63.95367 1.000 36.99687 ? 355 SER   B N   1 
ATOM   4761 C  CA  . SER   B 1 355 ? -5.96306  13.38736  -63.91971 1.000 37.84390 ? 355 SER   B CA  1 
ATOM   4762 C  C   . SER   B 1 355 ? -5.77066  12.75746  -65.30138 1.000 41.73793 ? 355 SER   B C   1 
ATOM   4763 O  O   . SER   B 1 355 ? -5.82284  13.45207  -66.32219 1.000 37.92912 ? 355 SER   B O   1 
ATOM   4764 C  CB  . SER   B 1 355 ? -7.40189  13.16429  -63.44444 1.000 36.30784 ? 355 SER   B CB  1 
ATOM   4765 O  OG  . SER   B 1 355 ? -7.69274  13.93382  -62.28943 1.000 34.45457 ? 355 SER   B OG  1 
ATOM   4766 N  N   . PRO   B 1 356 ? -5.54336  11.44053  -65.35519 1.000 42.60803 ? 356 PRO   B N   1 
ATOM   4767 C  CA  . PRO   B 1 356 ? -5.35583  10.76838  -66.64932 1.000 41.12912 ? 356 PRO   B CA  1 
ATOM   4768 C  C   . PRO   B 1 356 ? -6.45287  11.11592  -67.64508 1.000 42.42133 ? 356 PRO   B C   1 
ATOM   4769 O  O   . PRO   B 1 356 ? -7.64215  11.12836  -67.30890 1.000 36.99361 ? 356 PRO   B O   1 
ATOM   4770 C  CB  . PRO   B 1 356 ? -5.38803  9.27984   -66.27878 1.000 43.76921 ? 356 PRO   B CB  1 
ATOM   4771 C  CG  . PRO   B 1 356 ? -4.86312  9.23223   -64.88755 1.000 36.95022 ? 356 PRO   B CG  1 
ATOM   4772 C  CD  . PRO   B 1 356 ? -5.28810  10.52760  -64.22144 1.000 42.65448 ? 356 PRO   B CD  1 
ATOM   4773 N  N   . MET   B 1 357 ? -6.03649  11.42364  -68.87759 1.000 39.75759 ? 357 MET   B N   1 
ATOM   4774 C  CA  . MET   B 1 357 ? -6.90731  11.66829  -70.02393 1.000 37.02215 ? 357 MET   B CA  1 
ATOM   4775 C  C   . MET   B 1 357 ? -7.73988  12.93589  -69.88346 1.000 35.98731 ? 357 MET   B C   1 
ATOM   4776 O  O   . MET   B 1 357 ? -8.62006  13.18142  -70.71862 1.000 34.09610 ? 357 MET   B O   1 
ATOM   4777 C  CB  . MET   B 1 357 ? -7.82820  10.46926  -70.29266 1.000 41.48996 ? 357 MET   B CB  1 
ATOM   4778 C  CG  . MET   B 1 357 ? -7.07313  9.16802   -70.55158 1.000 33.62247 ? 357 MET   B CG  1 
ATOM   4779 S  SD  . MET   B 1 357 ? -8.11299  7.70268   -70.38691 1.000 49.11950 ? 357 MET   B SD  1 
ATOM   4780 C  CE  . MET   B 1 357 ? -8.62702  7.83500   -68.67234 1.000 41.58234 ? 357 MET   B CE  1 
ATOM   4781 N  N   . CYS   B 1 358 ? -7.47961  13.76001  -68.86543 1.000 36.93036 ? 358 CYS   B N   1 
ATOM   4782 C  CA  . CYS   B 1 358 ? -8.19897  15.01310  -68.65982 1.000 33.43205 ? 358 CYS   B CA  1 
ATOM   4783 C  C   . CYS   B 1 358 ? -7.42422  16.23411  -69.14572 1.000 32.37067 ? 358 CYS   B C   1 
ATOM   4784 O  O   . CYS   B 1 358 ? -7.93468  17.36037  -69.04863 1.000 29.57967 ? 358 CYS   B O   1 
ATOM   4785 C  CB  . CYS   B 1 358 ? -8.55430  15.17679  -67.17986 1.000 34.00436 ? 358 CYS   B CB  1 
ATOM   4786 S  SG  . CYS   B 1 358 ? -9.66480  13.88273  -66.56127 1.000 33.48115 ? 358 CYS   B SG  1 
ATOM   4787 N  N   . ASP   B 1 359 ? -6.21822  16.04268  -69.67516 1.000 31.10945 ? 359 ASP   B N   1 
ATOM   4788 C  CA  . ASP   B 1 359 ? -5.41378  17.14666  -70.19383 1.000 34.69838 ? 359 ASP   B CA  1 
ATOM   4789 C  C   . ASP   B 1 359 ? -5.70818  17.30613  -71.68191 1.000 34.06483 ? 359 ASP   B C   1 
ATOM   4790 O  O   . ASP   B 1 359 ? -5.24854  16.50367  -72.50136 1.000 35.34595 ? 359 ASP   B O   1 
ATOM   4791 C  CB  . ASP   B 1 359 ? -3.92670  16.89833  -69.94411 1.000 39.12528 ? 359 ASP   B CB  1 
ATOM   4792 C  CG  . ASP   B 1 359 ? -3.07030  18.11989  -70.25437 1.000 39.46115 ? 359 ASP   B CG  1 
ATOM   4793 O  OD1 . ASP   B 1 359 ? -3.64009  19.19975  -70.51946 1.000 38.67943 ? 359 ASP   B OD1 1 
ATOM   4794 O  OD2 . ASP   B 1 359 ? -1.83005  18.00063  -70.21262 1.000 42.69630 ? 359 ASP   B OD2 1 
ATOM   4795 N  N   . LYS   B 1 360 ? -6.47348  18.34543  -72.03011 1.000 32.90270 ? 360 LYS   B N   1 
ATOM   4796 C  CA  . LYS   B 1 360 ? -6.85716  18.58226  -73.41812 1.000 34.56963 ? 360 LYS   B CA  1 
ATOM   4797 C  C   . LYS   B 1 360 ? -5.68179  18.94741  -74.31508 1.000 44.54924 ? 360 LYS   B C   1 
ATOM   4798 O  O   . LYS   B 1 360 ? -5.86259  18.99176  -75.53785 1.000 45.00490 ? 360 LYS   B O   1 
ATOM   4799 C  CB  . LYS   B 1 360 ? -7.90654  19.68978  -73.49824 1.000 33.75008 ? 360 LYS   B CB  1 
ATOM   4800 C  CG  . LYS   B 1 360 ? -7.39817  21.06727  -73.09278 1.000 39.71672 ? 360 LYS   B CG  1 
ATOM   4801 C  CD  . LYS   B 1 360 ? -8.55472  22.04710  -72.97939 1.000 36.58183 ? 360 LYS   B CD  1 
ATOM   4802 C  CE  . LYS   B 1 360 ? -8.10971  23.38269  -72.41212 1.000 37.07942 ? 360 LYS   B CE  1 
ATOM   4803 N  NZ  . LYS   B 1 360 ? -9.29273  24.27171  -72.19115 1.000 38.76087 ? 360 LYS   B NZ  1 
ATOM   4804 N  N   . HIS   B 1 361 ? -4.49669  19.20839  -73.74596 1.000 43.37547 ? 361 HIS   B N   1 
ATOM   4805 C  CA  . HIS   B 1 361 ? -3.31110  19.55115  -74.52630 1.000 46.51505 ? 361 HIS   B CA  1 
ATOM   4806 C  C   . HIS   B 1 361 ? -2.41122  18.35552  -74.82407 1.000 45.87128 ? 361 HIS   B C   1 
ATOM   4807 O  O   . HIS   B 1 361 ? -1.54891  18.45994  -75.70056 1.000 53.49107 ? 361 HIS   B O   1 
ATOM   4808 C  CB  . HIS   B 1 361 ? -2.49080  20.64130  -73.81046 1.000 39.77107 ? 361 HIS   B CB  1 
ATOM   4809 C  CG  . HIS   B 1 361 ? -3.25468  21.90824  -73.56934 1.000 39.16977 ? 361 HIS   B CG  1 
ATOM   4810 N  ND1 . HIS   B 1 361 ? -3.89939  22.59273  -74.57870 1.000 45.04256 ? 361 HIS   B ND1 1 
ATOM   4811 C  CD2 . HIS   B 1 361 ? -3.49252  22.60577  -72.43309 1.000 39.18860 ? 361 HIS   B CD2 1 
ATOM   4812 C  CE1 . HIS   B 1 361 ? -4.49589  23.65999  -74.07627 1.000 45.03729 ? 361 HIS   B CE1 1 
ATOM   4813 N  NE2 . HIS   B 1 361 ? -4.26359  23.69175  -72.77553 1.000 47.22505 ? 361 HIS   B NE2 1 
ATOM   4814 N  N   . ASN   B 1 362 ? -2.56705  17.23746  -74.11517 1.000 43.38247 ? 362 ASN   B N   1 
ATOM   4815 C  CA  . ASN   B 1 362 ? -1.77764  16.03154  -74.37029 1.000 46.78001 ? 362 ASN   B CA  1 
ATOM   4816 C  C   . ASN   B 1 362 ? -2.65155  14.78777  -74.26028 1.000 45.37414 ? 362 ASN   B C   1 
ATOM   4817 O  O   . ASN   B 1 362 ? -2.35028  13.84302  -73.52862 1.000 47.84793 ? 362 ASN   B O   1 
ATOM   4818 C  CB  . ASN   B 1 362 ? -0.58701  15.92064  -73.42410 1.000 46.57837 ? 362 ASN   B CB  1 
ATOM   4819 C  CG  . ASN   B 1 362 ? 0.26820   17.16118  -73.42850 1.000 55.69320 ? 362 ASN   B CG  1 
ATOM   4820 O  OD1 . ASN   B 1 362 ? -0.19691  18.24194  -73.08094 1.000 59.03448 ? 362 ASN   B OD1 1 
ATOM   4821 N  ND2 . ASN   B 1 362 ? 1.53002   17.01441  -73.82066 1.000 54.28177 ? 362 ASN   B ND2 1 
ATOM   4822 N  N   . ALA   B 1 363 ? -3.74544  14.77480  -75.00403 1.000 41.47170 ? 363 ALA   B N   1 
ATOM   4823 C  CA  . ALA   B 1 363 ? -4.63880  13.63033  -75.06010 1.000 42.75619 ? 363 ALA   B CA  1 
ATOM   4824 C  C   . ALA   B 1 363 ? -4.41146  12.84347  -76.34634 1.000 36.39737 ? 363 ALA   B C   1 
ATOM   4825 O  O   . ALA   B 1 363 ? -3.89891  13.36405  -77.33914 1.000 36.29843 ? 363 ALA   B O   1 
ATOM   4826 C  CB  . ALA   B 1 363 ? -6.09866  14.08856  -74.97286 1.000 36.53363 ? 363 ALA   B CB  1 
ATOM   4827 N  N   . SER   B 1 364 ? -4.77719  11.56437  -76.31407 1.000 32.26865 ? 364 SER   B N   1 
ATOM   4828 C  CA  . SER   B 1 364 ? -5.03025  10.81056  -77.54334 1.000 28.63153 ? 364 SER   B CA  1 
ATOM   4829 C  C   . SER   B 1 364 ? -6.35754  10.09001  -77.34011 1.000 23.40508 ? 364 SER   B C   1 
ATOM   4830 O  O   . SER   B 1 364 ? -6.40572  9.00804   -76.74604 1.000 20.36680 ? 364 SER   B O   1 
ATOM   4831 C  CB  . SER   B 1 364 ? -3.91941  9.84953   -77.89459 1.000 28.61561 ? 364 SER   B CB  1 
ATOM   4832 O  OG  . SER   B 1 364 ? -4.26868  9.18073   -79.10855 1.000 40.62046 ? 364 SER   B OG  1 
ATOM   4833 N  N   . VAL   B 1 365 ? -7.42800  10.72630  -77.81779 1.000 21.86704 ? 365 VAL   B N   1 
ATOM   4834 C  CA  . VAL   B 1 365 ? -8.77921  10.20161  -77.64617 1.000 23.62255 ? 365 VAL   B CA  1 
ATOM   4835 C  C   . VAL   B 1 365 ? -8.87534  8.78377   -78.18396 1.000 21.45273 ? 365 VAL   B C   1 
ATOM   4836 O  O   . VAL   B 1 365 ? -9.45466  7.89037   -77.54318 1.000 18.54758 ? 365 VAL   B O   1 
ATOM   4837 C  CB  . VAL   B 1 365 ? -9.78291  11.13990  -78.34168 1.000 21.97305 ? 365 VAL   B CB  1 
ATOM   4838 C  CG1 . VAL   B 1 365 ? -11.18458 10.56005  -78.31885 1.000 20.77248 ? 365 VAL   B CG1 1 
ATOM   4839 C  CG2 . VAL   B 1 365 ? -9.71943  12.54504  -77.70219 1.000 20.86085 ? 365 VAL   B CG2 1 
ATOM   4840 N  N   . GLU   B 1 366 ? -8.28952  8.55280   -79.36335 1.000 18.19161 ? 366 GLU   B N   1 
ATOM   4841 C  CA  . GLU   B 1 366 ? -8.48208  7.28791   -80.06181 1.000 20.32606 ? 366 GLU   B CA  1 
ATOM   4842 C  C   . GLU   B 1 366 ? -7.73217  6.15697   -79.37391 1.000 21.70642 ? 366 GLU   B C   1 
ATOM   4843 O  O   . GLU   B 1 366 ? -8.29058  5.07319   -79.15192 1.000 21.99239 ? 366 GLU   B O   1 
ATOM   4844 C  CB  . GLU   B 1 366 ? -8.04306  7.42435   -81.52039 1.000 20.71636 ? 366 GLU   B CB  1 
ATOM   4845 C  CG  . GLU   B 1 366 ? -8.90723  8.39699   -82.33822 1.000 21.99832 ? 366 GLU   B CG  1 
ATOM   4846 C  CD  . GLU   B 1 366 ? -8.60031  9.87297   -82.06227 1.000 25.45607 ? 366 GLU   B CD  1 
ATOM   4847 O  OE1 . GLU   B 1 366 ? -9.48669  10.71585  -82.30266 1.000 23.85316 ? 366 GLU   B OE1 1 
ATOM   4848 O  OE2 . GLU   B 1 366 ? -7.48102  10.18014  -81.60371 1.000 23.53427 ? 366 GLU   B OE2 1 
ATOM   4849 N  N   . LYS   B 1 367 ? -6.46370  6.38512   -79.02881 1.000 18.21966 ? 367 LYS   B N   1 
ATOM   4850 C  CA  . LYS   B 1 367 ? -5.71501  5.34225   -78.34052 1.000 19.94766 ? 367 LYS   B CA  1 
ATOM   4851 C  C   . LYS   B 1 367 ? -6.30295  5.05891   -76.96620 1.000 19.30890 ? 367 LYS   B C   1 
ATOM   4852 O  O   . LYS   B 1 367 ? -6.21597  3.92573   -76.48953 1.000 19.80138 ? 367 LYS   B O   1 
ATOM   4853 C  CB  . LYS   B 1 367 ? -4.23477  5.70729   -78.20625 1.000 23.36982 ? 367 LYS   B CB  1 
ATOM   4854 C  CG  . LYS   B 1 367 ? -3.54096  6.01749   -79.50930 1.000 25.03007 ? 367 LYS   B CG  1 
ATOM   4855 C  CD  . LYS   B 1 367 ? -2.30523  6.85615   -79.24491 1.000 37.15733 ? 367 LYS   B CD  1 
ATOM   4856 C  CE  . LYS   B 1 367 ? -1.73491  7.42396   -80.53544 1.000 37.74929 ? 367 LYS   B CE  1 
ATOM   4857 N  NZ  . LYS   B 1 367 ? -0.25371  7.49454   -80.46941 1.000 41.86567 ? 367 LYS   B NZ  1 
ATOM   4858 N  N   . SER   B 1 368 ? -6.90706  6.06722   -76.32699 1.000 19.59485 ? 368 SER   B N   1 
ATOM   4859 C  CA  . SER   B 1 368 ? -7.54787  5.85299   -75.03293 1.000 21.38403 ? 368 SER   B CA  1 
ATOM   4860 C  C   . SER   B 1 368 ? -8.76121  4.93579   -75.15777 1.000 22.12981 ? 368 SER   B C   1 
ATOM   4861 O  O   . SER   B 1 368 ? -8.98631  4.07484   -74.29587 1.000 20.23746 ? 368 SER   B O   1 
ATOM   4862 C  CB  . SER   B 1 368 ? -7.96173  7.19481   -74.41840 1.000 21.68552 ? 368 SER   B CB  1 
ATOM   4863 O  OG  . SER   B 1 368 ? -6.82513  7.95834   -74.04958 1.000 28.59198 ? 368 SER   B OG  1 
ATOM   4864 N  N   . GLN   B 1 369 ? -9.56821  5.11911   -76.21421 1.000 18.86865 ? 369 GLN   B N   1 
ATOM   4865 C  CA  . GLN   B 1 369 ? -10.72987 4.25262   -76.41693 1.000 21.57121 ? 369 GLN   B CA  1 
ATOM   4866 C  C   . GLN   B 1 369 ? -10.31042 2.80740   -76.67659 1.000 19.35937 ? 369 GLN   B C   1 
ATOM   4867 O  O   . GLN   B 1 369 ? -10.91731 1.87293   -76.13834 1.000 17.73850 ? 369 GLN   B O   1 
ATOM   4868 C  CB  . GLN   B 1 369 ? -11.60052 4.77339   -77.56926 1.000 18.63386 ? 369 GLN   B CB  1 
ATOM   4869 C  CG  . GLN   B 1 369 ? -12.50163 5.94220   -77.18967 1.000 18.87333 ? 369 GLN   B CG  1 
ATOM   4870 C  CD  . GLN   B 1 369 ? -13.31936 5.66880   -75.92574 1.000 21.50871 ? 369 GLN   B CD  1 
ATOM   4871 O  OE1 . GLN   B 1 369 ? -14.13326 4.72829   -75.87095 1.000 17.37132 ? 369 GLN   B OE1 1 
ATOM   4872 N  NE2 . GLN   B 1 369 ? -13.09762 6.48980   -74.89609 1.000 18.39048 ? 369 GLN   B NE2 1 
ATOM   4873 N  N   . VAL   B 1 370 ? -9.28381  2.60061   -77.50334 1.000 20.05755 ? 370 VAL   B N   1 
ATOM   4874 C  CA  . VAL   B 1 370 ? -8.79157  1.24211   -77.74272 1.000 22.44818 ? 370 VAL   B CA  1 
ATOM   4875 C  C   . VAL   B 1 370 ? -8.32716  0.60556   -76.43525 1.000 23.27917 ? 370 VAL   B C   1 
ATOM   4876 O  O   . VAL   B 1 370 ? -8.64570  -0.55443  -76.14804 1.000 19.66755 ? 370 VAL   B O   1 
ATOM   4877 C  CB  . VAL   B 1 370 ? -7.67703  1.25018   -78.81017 1.000 19.70087 ? 370 VAL   B CB  1 
ATOM   4878 C  CG1 . VAL   B 1 370 ? -6.99563  -0.12531  -78.91053 1.000 19.47702 ? 370 VAL   B CG1 1 
ATOM   4879 C  CG2 . VAL   B 1 370 ? -8.25329  1.67111   -80.17944 1.000 19.73122 ? 370 VAL   B CG2 1 
ATOM   4880 N  N   . GLY   B 1 371 ? -7.59191  1.36024   -75.61384 1.000 20.76641 ? 371 GLY   B N   1 
ATOM   4881 C  CA  . GLY   B 1 371 ? -7.19709  0.84307   -74.30905 1.000 23.49434 ? 371 GLY   B CA  1 
ATOM   4882 C  C   . GLY   B 1 371 ? -8.38277  0.57232   -73.39785 1.000 24.39595 ? 371 GLY   B C   1 
ATOM   4883 O  O   . GLY   B 1 371 ? -8.43835  -0.46414  -72.72794 1.000 26.01623 ? 371 GLY   B O   1 
ATOM   4884 N  N   . PHE   B 1 372 ? -9.33938  1.51055   -73.35069 1.000 23.38820 ? 372 PHE   B N   1 
ATOM   4885 C  CA  . PHE   B 1 372 ? -10.59029 1.30767   -72.62318 1.000 19.68448 ? 372 PHE   B CA  1 
ATOM   4886 C  C   . PHE   B 1 372 ? -11.24542 -0.00776  -73.02382 1.000 20.12983 ? 372 PHE   B C   1 
ATOM   4887 O  O   . PHE   B 1 372 ? -11.65898 -0.79919  -72.16700 1.000 20.26556 ? 372 PHE   B O   1 
ATOM   4888 C  CB  . PHE   B 1 372 ? -11.52062 2.49528   -72.90788 1.000 23.00693 ? 372 PHE   B CB  1 
ATOM   4889 C  CG  . PHE   B 1 372 ? -12.80704 2.51023   -72.11953 1.000 22.98024 ? 372 PHE   B CG  1 
ATOM   4890 C  CD1 . PHE   B 1 372 ? -12.82844 2.22084   -70.75942 1.000 22.10387 ? 372 PHE   B CD1 1 
ATOM   4891 C  CD2 . PHE   B 1 372 ? -13.99785 2.90006   -72.73802 1.000 20.08527 ? 372 PHE   B CD2 1 
ATOM   4892 C  CE1 . PHE   B 1 372 ? -14.02516 2.28468   -70.03566 1.000 16.75325 ? 372 PHE   B CE1 1 
ATOM   4893 C  CE2 . PHE   B 1 372 ? -15.18957 2.96430   -72.02443 1.000 18.61655 ? 372 PHE   B CE2 1 
ATOM   4894 C  CZ  . PHE   B 1 372 ? -15.20041 2.65819   -70.66532 1.000 17.90967 ? 372 PHE   B CZ  1 
ATOM   4895 N  N   . ILE   B 1 373 ? -11.31607 -0.27090  -74.32758 1.000 20.25115 ? 373 ILE   B N   1 
ATOM   4896 C  CA  . ILE   B 1 373 ? -11.94187 -1.49506  -74.80954 1.000 21.76330 ? 373 ILE   B CA  1 
ATOM   4897 C  C   . ILE   B 1 373 ? -11.09856 -2.71105  -74.44178 1.000 24.01665 ? 373 ILE   B C   1 
ATOM   4898 O  O   . ILE   B 1 373 ? -11.61034 -3.69794  -73.89815 1.000 26.51222 ? 373 ILE   B O   1 
ATOM   4899 C  CB  . ILE   B 1 373 ? -12.17801 -1.40834  -76.32753 1.000 20.17055 ? 373 ILE   B CB  1 
ATOM   4900 C  CG1 . ILE   B 1 373 ? -13.32931 -0.44561  -76.62252 1.000 17.49970 ? 373 ILE   B CG1 1 
ATOM   4901 C  CG2 . ILE   B 1 373 ? -12.45193 -2.79436  -76.88582 1.000 18.03119 ? 373 ILE   B CG2 1 
ATOM   4902 C  CD1 . ILE   B 1 373 ? -13.49328 -0.11791  -78.09329 1.000 17.60363 ? 373 ILE   B CD1 1 
ATOM   4903 N  N   . ASP   B 1 374 ? -9.79233  -2.65319  -74.71921 1.000 19.28724 ? 374 ASP   B N   1 
ATOM   4904 C  CA  . ASP   B 1 374 ? -8.95019  -3.82910  -74.52722 1.000 26.06686 ? 374 ASP   B CA  1 
ATOM   4905 C  C   . ASP   B 1 374 ? -8.92874  -4.26021  -73.06569 1.000 29.37021 ? 374 ASP   B C   1 
ATOM   4906 O  O   . ASP   B 1 374 ? -9.00361  -5.45699  -72.76890 1.000 28.78704 ? 374 ASP   B O   1 
ATOM   4907 C  CB  . ASP   B 1 374 ? -7.52268  -3.55881  -75.01222 1.000 25.45051 ? 374 ASP   B CB  1 
ATOM   4908 C  CG  . ASP   B 1 374 ? -7.41273  -3.44976  -76.53366 1.000 22.67687 ? 374 ASP   B CG  1 
ATOM   4909 O  OD1 . ASP   B 1 374 ? -8.35032  -3.83947  -77.26552 1.000 21.86657 ? 374 ASP   B OD1 1 
ATOM   4910 O  OD2 . ASP   B 1 374 ? -6.36175  -2.97126  -76.99269 1.000 20.20739 ? 374 ASP   B OD2 1 
ATOM   4911 N  N   . TYR   B 1 375 ? -8.85189  -3.29604  -72.13865 1.000 26.79063 ? 375 TYR   B N   1 
ATOM   4912 C  CA  . TYR   B 1 375 ? -8.58382  -3.59003  -70.73622 1.000 29.78334 ? 375 TYR   B CA  1 
ATOM   4913 C  C   . TYR   B 1 375 ? -9.81738  -3.59179  -69.83499 1.000 26.64929 ? 375 TYR   B C   1 
ATOM   4914 O  O   . TYR   B 1 375 ? -9.77388  -4.21667  -68.77168 1.000 25.21181 ? 375 TYR   B O   1 
ATOM   4915 C  CB  . TYR   B 1 375 ? -7.56599  -2.59051  -70.18056 1.000 31.46282 ? 375 TYR   B CB  1 
ATOM   4916 C  CG  . TYR   B 1 375 ? -6.18272  -2.79505  -70.74483 1.000 35.96145 ? 375 TYR   B CG  1 
ATOM   4917 C  CD1 . TYR   B 1 375 ? -5.42121  -3.89538  -70.37274 1.000 41.14304 ? 375 TYR   B CD1 1 
ATOM   4918 C  CD2 . TYR   B 1 375 ? -5.64172  -1.90123  -71.65764 1.000 37.95243 ? 375 TYR   B CD2 1 
ATOM   4919 C  CE1 . TYR   B 1 375 ? -4.16068  -4.09748  -70.88380 1.000 39.35322 ? 375 TYR   B CE1 1 
ATOM   4920 C  CE2 . TYR   B 1 375 ? -4.37397  -2.09765  -72.17818 1.000 43.48914 ? 375 TYR   B CE2 1 
ATOM   4921 C  CZ  . TYR   B 1 375 ? -3.63874  -3.19805  -71.78367 1.000 45.16365 ? 375 TYR   B CZ  1 
ATOM   4922 O  OH  . TYR   B 1 375 ? -2.37558  -3.40247  -72.29211 1.000 49.23009 ? 375 TYR   B OH  1 
ATOM   4923 N  N   . ILE   B 1 376 ? -10.90169 -2.91721  -70.21494 1.000 22.27079 ? 376 ILE   B N   1 
ATOM   4924 C  CA  . ILE   B 1 376 ? -12.09788 -2.84424  -69.37913 1.000 19.79395 ? 376 ILE   B CA  1 
ATOM   4925 C  C   . ILE   B 1 376 ? -13.30205 -3.43352  -70.10023 1.000 23.04060 ? 376 ILE   B C   1 
ATOM   4926 O  O   . ILE   B 1 376 ? -13.93629 -4.38027  -69.61683 1.000 18.57367 ? 376 ILE   B O   1 
ATOM   4927 C  CB  . ILE   B 1 376 ? -12.40682 -1.39392  -68.96344 1.000 20.98811 ? 376 ILE   B CB  1 
ATOM   4928 C  CG1 . ILE   B 1 376 ? -11.22723 -0.78751  -68.20461 1.000 22.15114 ? 376 ILE   B CG1 1 
ATOM   4929 C  CG2 . ILE   B 1 376 ? -13.68668 -1.33344  -68.13299 1.000 20.75730 ? 376 ILE   B CG2 1 
ATOM   4930 C  CD1 . ILE   B 1 376 ? -10.82081 -1.58259  -66.99466 1.000 27.79812 ? 376 ILE   B CD1 1 
ATOM   4931 N  N   . VAL   B 1 377 ? -13.64167 -2.85524  -71.25121 1.000 18.81013 ? 377 VAL   B N   1 
ATOM   4932 C  CA  . VAL   B 1 377 ? -14.95577 -3.09138  -71.82807 1.000 16.75237 ? 377 VAL   B CA  1 
ATOM   4933 C  C   . VAL   B 1 377 ? -15.03215 -4.46932  -72.48006 1.000 23.92024 ? 377 VAL   B C   1 
ATOM   4934 O  O   . VAL   B 1 377 ? -16.03806 -5.17719  -72.33847 1.000 19.62872 ? 377 VAL   B O   1 
ATOM   4935 C  CB  . VAL   B 1 377 ? -15.31293 -1.96799  -72.81371 1.000 16.80053 ? 377 VAL   B CB  1 
ATOM   4936 C  CG1 . VAL   B 1 377 ? -16.67691 -2.20906  -73.39818 1.000 15.75982 ? 377 VAL   B CG1 1 
ATOM   4937 C  CG2 . VAL   B 1 377 ? -15.28203 -0.60637  -72.10598 1.000 19.50330 ? 377 VAL   B CG2 1 
ATOM   4938 N  N   . HIS   B 1 378 ? -13.99364 -4.87593  -73.21617 1.000 23.83724 ? 378 HIS   B N   1 
ATOM   4939 C  CA  . HIS   B 1 378 ? -14.05462 -6.20188  -73.83421 1.000 25.63090 ? 378 HIS   B CA  1 
ATOM   4940 C  C   . HIS   B 1 378 ? -13.94864 -7.31857  -72.80321 1.000 24.32071 ? 378 HIS   B C   1 
ATOM   4941 O  O   . HIS   B 1 378 ? -14.72138 -8.28602  -72.90299 1.000 24.63495 ? 378 HIS   B O   1 
ATOM   4942 C  CB  . HIS   B 1 378 ? -12.99323 -6.34438  -74.93268 1.000 22.51491 ? 378 HIS   B CB  1 
ATOM   4943 C  CG  . HIS   B 1 378 ? -13.22502 -7.51593  -75.83859 1.000 27.07865 ? 378 HIS   B CG  1 
ATOM   4944 N  ND1 . HIS   B 1 378 ? -12.64754 -8.75120  -75.62712 1.000 27.51074 ? 378 HIS   B ND1 1 
ATOM   4945 C  CD2 . HIS   B 1 378 ? -13.98793 -7.64399  -76.95072 1.000 28.23337 ? 378 HIS   B CD2 1 
ATOM   4946 C  CE1 . HIS   B 1 378 ? -13.03749 -9.58592  -76.57478 1.000 31.22379 ? 378 HIS   B CE1 1 
ATOM   4947 N  NE2 . HIS   B 1 378 ? -13.84889 -8.93778  -77.39311 1.000 33.45921 ? 378 HIS   B NE2 1 
ATOM   4948 N  N   . PRO   B 1 379 ? -13.03968 -7.27736  -71.81817 1.000 24.45536 ? 379 PRO   B N   1 
ATOM   4949 C  CA  . PRO   B 1 379 ? -13.03770 -8.35866  -70.82208 1.000 22.67959 ? 379 PRO   B CA  1 
ATOM   4950 C  C   . PRO   B 1 379 ? -14.37020 -8.50023  -70.12273 1.000 27.10334 ? 379 PRO   B C   1 
ATOM   4951 O  O   . PRO   B 1 379 ? -14.79992 -9.62731  -69.84809 1.000 27.26105 ? 379 PRO   B O   1 
ATOM   4952 C  CB  . PRO   B 1 379 ? -11.91876 -7.94835  -69.85962 1.000 24.61669 ? 379 PRO   B CB  1 
ATOM   4953 C  CG  . PRO   B 1 379 ? -10.99671 -7.12896  -70.69658 1.000 24.19111 ? 379 PRO   B CG  1 
ATOM   4954 C  CD  . PRO   B 1 379 ? -11.88349 -6.37471  -71.64022 1.000 22.93751 ? 379 PRO   B CD  1 
ATOM   4955 N  N   . LEU   B 1 380 ? -15.05973 -7.38211  -69.86877 1.000 23.13895 ? 380 LEU   B N   1 
ATOM   4956 C  CA  . LEU   B 1 380 ? -16.37256 -7.43557  -69.23655 1.000 25.62992 ? 380 LEU   B CA  1 
ATOM   4957 C  C   . LEU   B 1 380 ? -17.41062 -8.06439  -70.16069 1.000 25.54373 ? 380 LEU   B C   1 
ATOM   4958 O  O   . LEU   B 1 380 ? -18.11879 -8.99780  -69.76763 1.000 25.26721 ? 380 LEU   B O   1 
ATOM   4959 C  CB  . LEU   B 1 380 ? -16.81368 -6.03126  -68.81156 1.000 22.16522 ? 380 LEU   B CB  1 
ATOM   4960 C  CG  . LEU   B 1 380 ? -18.21234 -5.97793  -68.19810 1.000 25.25582 ? 380 LEU   B CG  1 
ATOM   4961 C  CD1 . LEU   B 1 380 ? -18.26928 -6.89528  -66.96683 1.000 19.14161 ? 380 LEU   B CD1 1 
ATOM   4962 C  CD2 . LEU   B 1 380 ? -18.61567 -4.53799  -67.82474 1.000 19.49676 ? 380 LEU   B CD2 1 
ATOM   4963 N  N   . TRP   B 1 381 ? -17.53521 -7.55328  -71.38875 1.000 20.31624 ? 381 TRP   B N   1 
ATOM   4964 C  CA  . TRP   B 1 381 ? -18.57687 -8.05191  -72.27868 1.000 19.96592 ? 381 TRP   B CA  1 
ATOM   4965 C  C   . TRP   B 1 381 ? -18.27850 -9.45231  -72.80043 1.000 25.49092 ? 381 TRP   B C   1 
ATOM   4966 O  O   . TRP   B 1 381 ? -19.21307 -10.16028 -73.18819 1.000 23.83173 ? 381 TRP   B O   1 
ATOM   4967 C  CB  . TRP   B 1 381 ? -18.78101 -7.08995  -73.44005 1.000 20.19960 ? 381 TRP   B CB  1 
ATOM   4968 C  CG  . TRP   B 1 381 ? -19.61679 -5.94875  -73.05523 1.000 20.04033 ? 381 TRP   B CG  1 
ATOM   4969 C  CD1 . TRP   B 1 381 ? -19.19511 -4.69451  -72.71391 1.000 20.08987 ? 381 TRP   B CD1 1 
ATOM   4970 C  CD2 . TRP   B 1 381 ? -21.03722 -5.94824  -72.93017 1.000 16.37610 ? 381 TRP   B CD2 1 
ATOM   4971 N  NE1 . TRP   B 1 381 ? -20.27828 -3.90613  -72.40584 1.000 21.02725 ? 381 TRP   B NE1 1 
ATOM   4972 C  CE2 . TRP   B 1 381 ? -21.42134 -4.65810  -72.53014 1.000 16.23009 ? 381 TRP   B CE2 1 
ATOM   4973 C  CE3 . TRP   B 1 381 ? -22.02949 -6.91709  -73.13207 1.000 18.96366 ? 381 TRP   B CE3 1 
ATOM   4974 C  CZ2 . TRP   B 1 381 ? -22.75298 -4.30766  -72.33358 1.000 17.96733 ? 381 TRP   B CZ2 1 
ATOM   4975 C  CZ3 . TRP   B 1 381 ? -23.34515 -6.56592  -72.93595 1.000 19.90466 ? 381 TRP   B CZ3 1 
ATOM   4976 C  CH2 . TRP   B 1 381 ? -23.69833 -5.27248  -72.53906 1.000 18.89133 ? 381 TRP   B CH2 1 
ATOM   4977 N  N   . GLU   B 1 382 ? -17.00535 -9.85552  -72.81947 1.000 24.09265 ? 382 GLU   B N   1 
ATOM   4978 C  CA  . GLU   B 1 382 ? -16.65078 -11.23288 -73.15117 1.000 33.00756 ? 382 GLU   B CA  1 
ATOM   4979 C  C   . GLU   B 1 382 ? -17.14593 -12.20395 -72.08794 1.000 33.65539 ? 382 GLU   B C   1 
ATOM   4980 O  O   . GLU   B 1 382 ? -17.62594 -13.30142 -72.40800 1.000 34.07852 ? 382 GLU   B O   1 
ATOM   4981 C  CB  . GLU   B 1 382 ? -15.13878 -11.36347 -73.29855 1.000 27.90810 ? 382 GLU   B CB  1 
ATOM   4982 C  CG  . GLU   B 1 382 ? -14.67768 -12.75129 -73.69259 1.000 41.35518 ? 382 GLU   B CG  1 
ATOM   4983 C  CD  . GLU   B 1 382 ? -13.48907 -12.70577 -74.63219 1.000 44.20117 ? 382 GLU   B CD  1 
ATOM   4984 O  OE1 . GLU   B 1 382 ? -12.38490 -12.31899 -74.18287 1.000 52.58358 ? 382 GLU   B OE1 1 
ATOM   4985 O  OE2 . GLU   B 1 382 ? -13.65902 -13.03238 -75.83194 1.000 51.78010 ? 382 GLU   B OE2 1 
ATOM   4986 N  N   . THR   B 1 383 ? -17.02074 -11.82241 -70.81758 1.000 32.66429 ? 383 THR   B N   1 
ATOM   4987 C  CA  . THR   B 1 383 ? -17.49347 -12.68404 -69.74414 1.000 32.41870 ? 383 THR   B CA  1 
ATOM   4988 C  C   . THR   B 1 383 ? -19.01631 -12.69128 -69.68660 1.000 30.81253 ? 383 THR   B C   1 
ATOM   4989 O  O   . THR   B 1 383 ? -19.63015 -13.74731 -69.48566 1.000 32.75771 ? 383 THR   B O   1 
ATOM   4990 C  CB  . THR   B 1 383 ? -16.87164 -12.23979 -68.42289 1.000 29.02801 ? 383 THR   B CB  1 
ATOM   4991 O  OG1 . THR   B 1 383 ? -15.46016 -12.07888 -68.60922 1.000 28.31392 ? 383 THR   B OG1 1 
ATOM   4992 C  CG2 . THR   B 1 383 ? -17.10559 -13.28454 -67.33301 1.000 30.04948 ? 383 THR   B CG2 1 
ATOM   4993 N  N   . TRP   B 1 384 ? -19.64846 -11.53691 -69.91931 1.000 25.16831 ? 384 TRP   B N   1 
ATOM   4994 C  CA  . TRP   B 1 384 ? -21.10681 -11.50081 -69.96567 1.000 22.15545 ? 384 TRP   B CA  1 
ATOM   4995 C  C   . TRP   B 1 384 ? -21.66838 -12.32216 -71.12372 1.000 31.83465 ? 384 TRP   B C   1 
ATOM   4996 O  O   . TRP   B 1 384 ? -22.72911 -12.94653 -70.98855 1.000 26.86179 ? 384 TRP   B O   1 
ATOM   4997 C  CB  . TRP   B 1 384 ? -21.59865 -10.06939 -70.08081 1.000 22.79713 ? 384 TRP   B CB  1 
ATOM   4998 C  CG  . TRP   B 1 384 ? -23.07488 -10.00555 -70.14610 1.000 24.87936 ? 384 TRP   B CG  1 
ATOM   4999 C  CD1 . TRP   B 1 384 ? -23.85620 -9.96850  -71.27043 1.000 23.24984 ? 384 TRP   B CD1 1 
ATOM   5000 C  CD2 . TRP   B 1 384 ? -23.96896 -9.98138  -69.03229 1.000 24.34005 ? 384 TRP   B CD2 1 
ATOM   5001 N  NE1 . TRP   B 1 384 ? -25.18049 -9.91489  -70.92121 1.000 23.97520 ? 384 TRP   B NE1 1 
ATOM   5002 C  CE2 . TRP   B 1 384 ? -25.27881 -9.92206  -69.55176 1.000 26.91700 ? 384 TRP   B CE2 1 
ATOM   5003 C  CE3 . TRP   B 1 384 ? -23.78849 -9.99361  -67.64066 1.000 24.36164 ? 384 TRP   B CE3 1 
ATOM   5004 C  CZ2 . TRP   B 1 384 ? -26.40520 -9.87640  -68.73029 1.000 22.55684 ? 384 TRP   B CZ2 1 
ATOM   5005 C  CZ3 . TRP   B 1 384 ? -24.91331 -9.95452  -66.82799 1.000 18.33887 ? 384 TRP   B CZ3 1 
ATOM   5006 C  CH2 . TRP   B 1 384 ? -26.19921 -9.89101  -67.37701 1.000 18.69675 ? 384 TRP   B CH2 1 
ATOM   5007 N  N   . ALA   B 1 385 ? -21.00329 -12.29595 -72.28548 1.000 29.33906 ? 385 ALA   B N   1 
ATOM   5008 C  CA  . ALA   B 1 385 ? -21.52084 -13.02188 -73.44282 1.000 29.53513 ? 385 ALA   B CA  1 
ATOM   5009 C  C   . ALA   B 1 385 ? -21.49727 -14.52689 -73.20253 1.000 28.70798 ? 385 ALA   B C   1 
ATOM   5010 O  O   . ALA   B 1 385 ? -22.43915 -15.23279 -73.57864 1.000 29.88842 ? 385 ALA   B O   1 
ATOM   5011 C  CB  . ALA   B 1 385 ? -20.72305 -12.66181 -74.70108 1.000 28.86036 ? 385 ALA   B CB  1 
ATOM   5012 N  N   . ASP   B 1 386 ? -20.41289 -15.03222 -72.60376 1.000 24.62860 ? 386 ASP   B N   1 
ATOM   5013 C  CA  . ASP   B 1 386 ? -20.37233 -16.40887 -72.11743 1.000 31.72445 ? 386 ASP   B CA  1 
ATOM   5014 C  C   . ASP   B 1 386 ? -21.57197 -16.72340 -71.22474 1.000 36.08353 ? 386 ASP   B C   1 
ATOM   5015 O  O   . ASP   B 1 386 ? -22.30714 -17.68664 -71.47069 1.000 38.02343 ? 386 ASP   B O   1 
ATOM   5016 C  CB  . ASP   B 1 386 ? -19.06408 -16.65598 -71.35782 1.000 30.62842 ? 386 ASP   B CB  1 
ATOM   5017 C  CG  . ASP   B 1 386 ? -17.84778 -16.64959 -72.26986 1.000 39.86507 ? 386 ASP   B CG  1 
ATOM   5018 O  OD1 . ASP   B 1 386 ? -18.03255 -16.57284 -73.50504 1.000 40.58858 ? 386 ASP   B OD1 1 
ATOM   5019 O  OD2 . ASP   B 1 386 ? -16.70669 -16.74301 -71.76090 1.000 42.72916 ? 386 ASP   B OD2 1 
ATOM   5020 N  N   . LEU   B 1 387 ? -21.79424 -15.90495 -70.18986 1.000 35.25060 ? 387 LEU   B N   1 
ATOM   5021 C  CA  . LEU   B 1 387 ? -22.86681 -16.17077 -69.23532 1.000 32.61727 ? 387 LEU   B CA  1 
ATOM   5022 C  C   . LEU   B 1 387 ? -24.21628 -16.33570 -69.92660 1.000 35.12352 ? 387 LEU   B C   1 
ATOM   5023 O  O   . LEU   B 1 387 ? -25.03242 -17.16777 -69.51560 1.000 34.27502 ? 387 LEU   B O   1 
ATOM   5024 C  CB  . LEU   B 1 387 ? -22.93788 -15.04917 -68.19253 1.000 32.47237 ? 387 LEU   B CB  1 
ATOM   5025 C  CG  . LEU   B 1 387 ? -23.87100 -15.31045 -67.00111 1.000 30.35160 ? 387 LEU   B CG  1 
ATOM   5026 C  CD1 . LEU   B 1 387 ? -23.20875 -16.28775 -66.05247 1.000 27.79030 ? 387 LEU   B CD1 1 
ATOM   5027 C  CD2 . LEU   B 1 387 ? -24.24882 -14.02249 -66.28826 1.000 26.89707 ? 387 LEU   B CD2 1 
ATOM   5028 N  N   . VAL   B 1 388 ? -24.47124 -15.56477 -70.97963 1.000 31.08304 ? 388 VAL   B N   1 
ATOM   5029 C  CA  . VAL   B 1 388 ? -25.75733 -15.60756 -71.65473 1.000 29.15277 ? 388 VAL   B CA  1 
ATOM   5030 C  C   . VAL   B 1 388 ? -25.63829 -16.20234 -73.06106 1.000 31.55323 ? 388 VAL   B C   1 
ATOM   5031 O  O   . VAL   B 1 388 ? -26.53266 -16.01379 -73.88754 1.000 30.32134 ? 388 VAL   B O   1 
ATOM   5032 C  CB  . VAL   B 1 388 ? -26.41642 -14.21878 -71.67697 1.000 33.40135 ? 388 VAL   B CB  1 
ATOM   5033 C  CG1 . VAL   B 1 388 ? -26.63255 -13.72319 -70.24614 1.000 25.91656 ? 388 VAL   B CG1 1 
ATOM   5034 C  CG2 . VAL   B 1 388 ? -25.56756 -13.22396 -72.48376 1.000 29.66506 ? 388 VAL   B CG2 1 
ATOM   5035 N  N   . HIS   B 1 389 ? -24.55036 -16.92440 -73.32927 1.000 24.01148 ? 389 HIS   B N   1 
ATOM   5036 C  CA  . HIS   B 1 389 ? -24.27416 -17.57307 -74.62157 1.000 37.44792 ? 389 HIS   B CA  1 
ATOM   5037 C  C   . HIS   B 1 389 ? -25.53016 -18.24435 -75.18512 1.000 43.72560 ? 389 HIS   B C   1 
ATOM   5038 O  O   . HIS   B 1 389 ? -26.12353 -19.09362 -74.52029 1.000 41.50182 ? 389 HIS   B O   1 
ATOM   5039 C  CB  . HIS   B 1 389 ? -23.13832 -18.59246 -74.43560 1.000 35.78692 ? 389 HIS   B CB  1 
ATOM   5040 C  CG  . HIS   B 1 389 ? -22.58458 -19.15650 -75.70869 1.000 50.76151 ? 389 HIS   B CG  1 
ATOM   5041 N  ND1 . HIS   B 1 389 ? -23.04408 -18.79640 -76.95567 1.000 52.93674 ? 389 HIS   B ND1 1 
ATOM   5042 C  CD2 . HIS   B 1 389 ? -21.60442 -20.06803 -75.92235 1.000 52.85608 ? 389 HIS   B CD2 1 
ATOM   5043 C  CE1 . HIS   B 1 389 ? -22.37849 -19.46051 -77.88341 1.000 51.15635 ? 389 HIS   B CE1 1 
ATOM   5044 N  NE2 . HIS   B 1 389 ? -21.49633 -20.23915 -77.28233 1.000 56.49084 ? 389 HIS   B NE2 1 
ATOM   5045 N  N   . PRO   B 1 390 ? -25.95284 -17.85911 -76.40719 1.000 45.95906 ? 390 PRO   B N   1 
ATOM   5046 C  CA  . PRO   B 1 390 ? -25.32226 -16.95333 -77.37415 1.000 40.70023 ? 390 PRO   B CA  1 
ATOM   5047 C  C   . PRO   B 1 390 ? -25.99328 -15.59957 -77.52612 1.000 37.66422 ? 390 PRO   B C   1 
ATOM   5048 O  O   . PRO   B 1 390 ? -25.80667 -14.97080 -78.56622 1.000 33.91004 ? 390 PRO   B O   1 
ATOM   5049 C  CB  . PRO   B 1 390 ? -25.47458 -17.73241 -78.67887 1.000 38.90267 ? 390 PRO   B CB  1 
ATOM   5050 C  CG  . PRO   B 1 390 ? -26.89470 -18.31357 -78.52753 1.000 37.92765 ? 390 PRO   B CG  1 
ATOM   5051 C  CD  . PRO   B 1 390 ? -27.12256 -18.51779 -77.01653 1.000 41.52140 ? 390 PRO   B CD  1 
ATOM   5052 N  N   . ASP   B 1 391 ? -26.76420 -15.15155 -76.53753 1.000 29.76858 ? 391 ASP   B N   1 
ATOM   5053 C  CA  . ASP   B 1 391 ? -27.64230 -14.01790 -76.79716 1.000 36.21652 ? 391 ASP   B CA  1 
ATOM   5054 C  C   . ASP   B 1 391 ? -26.90431 -12.69375 -76.96561 1.000 33.60878 ? 391 ASP   B C   1 
ATOM   5055 O  O   . ASP   B 1 391 ? -27.52128 -11.72170 -77.40734 1.000 30.12241 ? 391 ASP   B O   1 
ATOM   5056 C  CB  . ASP   B 1 391 ? -28.65604 -13.87726 -75.67715 1.000 36.65384 ? 391 ASP   B CB  1 
ATOM   5057 C  CG  . ASP   B 1 391 ? -29.42728 -15.15264 -75.43066 1.000 43.35822 ? 391 ASP   B CG  1 
ATOM   5058 O  OD1 . ASP   B 1 391 ? -29.47711 -16.01378 -76.33901 1.000 46.53962 ? 391 ASP   B OD1 1 
ATOM   5059 O  OD2 . ASP   B 1 391 ? -29.97050 -15.29318 -74.31864 1.000 43.40919 ? 391 ASP   B OD2 1 
ATOM   5060 N  N   . ALA   B 1 392 ? -25.62143 -12.62441 -76.62732 1.000 29.72269 ? 392 ALA   B N   1 
ATOM   5061 C  CA  . ALA   B 1 392 ? -24.88838 -11.36437 -76.65548 1.000 34.10024 ? 392 ALA   B CA  1 
ATOM   5062 C  C   . ALA   B 1 392 ? -23.92634 -11.28029 -77.82979 1.000 32.48821 ? 392 ALA   B C   1 
ATOM   5063 O  O   . ALA   B 1 392 ? -23.09529 -10.36634 -77.87558 1.000 31.92179 ? 392 ALA   B O   1 
ATOM   5064 C  CB  . ALA   B 1 392 ? -24.13299 -11.16399 -75.33861 1.000 27.41002 ? 392 ALA   B CB  1 
ATOM   5065 N  N   . GLN   B 1 393 ? -24.01960 -12.21125 -78.78339 1.000 33.45279 ? 393 GLN   B N   1 
ATOM   5066 C  CA  . GLN   B 1 393 ? -23.02944 -12.26714 -79.85320 1.000 30.87998 ? 393 GLN   B CA  1 
ATOM   5067 C  C   . GLN   B 1 393 ? -23.05703 -11.00729 -80.71178 1.000 27.57793 ? 393 GLN   B C   1 
ATOM   5068 O  O   . GLN   B 1 393 ? -21.99800 -10.47566 -81.06044 1.000 28.49725 ? 393 GLN   B O   1 
ATOM   5069 C  CB  . GLN   B 1 393 ? -23.25303 -13.50447 -80.71282 1.000 30.73142 ? 393 GLN   B CB  1 
ATOM   5070 C  CG  . GLN   B 1 393 ? -22.10956 -13.77235 -81.65074 1.000 36.30616 ? 393 GLN   B CG  1 
ATOM   5071 C  CD  . GLN   B 1 393 ? -20.83928 -14.06857 -80.90859 1.000 38.47760 ? 393 GLN   B CD  1 
ATOM   5072 O  OE1 . GLN   B 1 393 ? -20.77425 -15.02849 -80.14709 1.000 42.65760 ? 393 GLN   B OE1 1 
ATOM   5073 N  NE2 . GLN   B 1 393 ? -19.80958 -13.25249 -81.12736 1.000 35.66892 ? 393 GLN   B NE2 1 
ATOM   5074 N  N   . ASP   B 1 394 ? -24.25446 -10.52040 -81.06486 1.000 26.39795 ? 394 ASP   B N   1 
ATOM   5075 C  CA  . ASP   B 1 394 ? -24.36629 -9.29607  -81.85736 1.000 29.41296 ? 394 ASP   B CA  1 
ATOM   5076 C  C   . ASP   B 1 394 ? -23.76989 -8.10350  -81.12251 1.000 31.89390 ? 394 ASP   B C   1 
ATOM   5077 O  O   . ASP   B 1 394 ? -23.08899 -7.26313  -81.72517 1.000 27.31274 ? 394 ASP   B O   1 
ATOM   5078 C  CB  . ASP   B 1 394 ? -25.82803 -9.00000  -82.19410 1.000 33.12990 ? 394 ASP   B CB  1 
ATOM   5079 C  CG  . ASP   B 1 394 ? -26.45823 -10.05051 -83.08463 1.000 36.57039 ? 394 ASP   B CG  1 
ATOM   5080 O  OD1 . ASP   B 1 394 ? -25.73401 -10.93801 -83.59321 1.000 39.15138 ? 394 ASP   B OD1 1 
ATOM   5081 O  OD2 . ASP   B 1 394 ? -27.68852 -9.96691  -83.27607 1.000 38.23063 ? 394 ASP   B OD2 1 
ATOM   5082 N  N   . ILE   B 1 395 ? -24.06969 -7.98190  -79.82641 1.000 29.50749 ? 395 ILE   B N   1 
ATOM   5083 C  CA  . ILE   B 1 395 ? -23.45817 -6.93123  -79.01885 1.000 26.72119 ? 395 ILE   B CA  1 
ATOM   5084 C  C   . ILE   B 1 395 ? -21.94270 -7.05073  -79.06582 1.000 25.55469 ? 395 ILE   B C   1 
ATOM   5085 O  O   . ILE   B 1 395 ? -21.23367 -6.07942  -79.35292 1.000 28.22242 ? 395 ILE   B O   1 
ATOM   5086 C  CB  . ILE   B 1 395 ? -23.97719 -6.98316  -77.56997 1.000 27.34984 ? 395 ILE   B CB  1 
ATOM   5087 C  CG1 . ILE   B 1 395 ? -25.46073 -6.64021  -77.52077 1.000 27.19038 ? 395 ILE   B CG1 1 
ATOM   5088 C  CG2 . ILE   B 1 395 ? -23.18536 -6.01575  -76.68996 1.000 24.13900 ? 395 ILE   B CG2 1 
ATOM   5089 C  CD1 . ILE   B 1 395 ? -26.04034 -6.74747  -76.13260 1.000 30.41069 ? 395 ILE   B CD1 1 
ATOM   5090 N  N   . LEU   B 1 396 ? -21.42128 -8.24599  -78.79587 1.000 21.43389 ? 396 LEU   B N   1 
ATOM   5091 C  CA  . LEU   B 1 396 ? -19.97291 -8.42377  -78.80274 1.000 20.36006 ? 396 LEU   B CA  1 
ATOM   5092 C  C   . LEU   B 1 396 ? -19.39163 -8.15041  -80.18769 1.000 30.09617 ? 396 LEU   B C   1 
ATOM   5093 O  O   . LEU   B 1 396 ? -18.28682 -7.60677  -80.30750 1.000 26.91526 ? 396 LEU   B O   1 
ATOM   5094 C  CB  . LEU   B 1 396 ? -19.62708 -9.83135  -78.33452 1.000 26.37293 ? 396 LEU   B CB  1 
ATOM   5095 C  CG  . LEU   B 1 396 ? -18.17439 -10.18137 -78.05021 1.000 30.12826 ? 396 LEU   B CG  1 
ATOM   5096 C  CD1 . LEU   B 1 396 ? -17.60407 -9.26983  -76.96945 1.000 28.23376 ? 396 LEU   B CD1 1 
ATOM   5097 C  CD2 . LEU   B 1 396 ? -18.10661 -11.63861 -77.62023 1.000 28.29098 ? 396 LEU   B CD2 1 
ATOM   5098 N  N   . ASP   B 1 397 ? -20.13992 -8.49521  -81.24605 1.000 28.52017 ? 397 ASP   B N   1 
ATOM   5099 C  CA  . ASP   B 1 397 ? -19.68602 -8.23531  -82.61186 1.000 30.22365 ? 397 ASP   B CA  1 
ATOM   5100 C  C   . ASP   B 1 397 ? -19.53418 -6.73584  -82.86895 1.000 22.69514 ? 397 ASP   B C   1 
ATOM   5101 O  O   . ASP   B 1 397 ? -18.53941 -6.29523  -83.45031 1.000 24.38413 ? 397 ASP   B O   1 
ATOM   5102 C  CB  . ASP   B 1 397 ? -20.65587 -8.85852  -83.62803 1.000 27.80847 ? 397 ASP   B CB  1 
ATOM   5103 C  CG  . ASP   B 1 397 ? -20.58865 -10.40648 -83.67185 1.000 29.05707 ? 397 ASP   B CG  1 
ATOM   5104 O  OD1 . ASP   B 1 397 ? -19.60536 -11.01602 -83.19056 1.000 27.09619 ? 397 ASP   B OD1 1 
ATOM   5105 O  OD2 . ASP   B 1 397 ? -21.54260 -11.00595 -84.21053 1.000 28.13575 ? 397 ASP   B OD2 1 
ATOM   5106 N  N   . THR   B 1 398 ? -20.52665 -5.93901  -82.46012 1.000 25.46659 ? 398 THR   B N   1 
ATOM   5107 C  CA  . THR   B 1 398 ? -20.45270 -4.49625  -82.66932 1.000 25.67312 ? 398 THR   B CA  1 
ATOM   5108 C  C   . THR   B 1 398 ? -19.27151 -3.89025  -81.92366 1.000 25.39817 ? 398 THR   B C   1 
ATOM   5109 O  O   . THR   B 1 398 ? -18.62646 -2.95918  -82.42477 1.000 23.61527 ? 398 THR   B O   1 
ATOM   5110 C  CB  . THR   B 1 398 ? -21.75498 -3.82283  -82.23025 1.000 24.61003 ? 398 THR   B CB  1 
ATOM   5111 O  OG1 . THR   B 1 398 ? -22.86544 -4.41223  -82.91699 1.000 23.80458 ? 398 THR   B OG1 1 
ATOM   5112 C  CG2 . THR   B 1 398 ? -21.72018 -2.34518  -82.55503 1.000 18.10898 ? 398 THR   B CG2 1 
ATOM   5113 N  N   . LEU   B 1 399 ? -18.97385 -4.41203  -80.72505 1.000 24.14421 ? 399 LEU   B N   1 
ATOM   5114 C  CA  . LEU   B 1 399 ? -17.84310 -3.92200  -79.94123 1.000 23.75155 ? 399 LEU   B CA  1 
ATOM   5115 C  C   . LEU   B 1 399 ? -16.52853 -4.16381  -80.66889 1.000 25.20504 ? 399 LEU   B C   1 
ATOM   5116 O  O   . LEU   B 1 399 ? -15.66667 -3.27903  -80.73824 1.000 22.67722 ? 399 LEU   B O   1 
ATOM   5117 C  CB  . LEU   B 1 399 ? -17.81914 -4.59860  -78.56585 1.000 19.99066 ? 399 LEU   B CB  1 
ATOM   5118 C  CG  . LEU   B 1 399 ? -16.60743 -4.30801  -77.66153 1.000 23.87849 ? 399 LEU   B CG  1 
ATOM   5119 C  CD1 . LEU   B 1 399 ? -16.59874 -2.82815  -77.22822 1.000 19.03354 ? 399 LEU   B CD1 1 
ATOM   5120 C  CD2 . LEU   B 1 399 ? -16.55245 -5.22163  -76.43377 1.000 19.15782 ? 399 LEU   B CD2 1 
ATOM   5121 N  N   . GLU   B 1 400 ? -16.34803 -5.37119  -81.20378 1.000 24.81813 ? 400 GLU   B N   1 
ATOM   5122 C  CA  . GLU   B 1 400 ? -15.09331 -5.69900  -81.87313 1.000 22.57644 ? 400 GLU   B CA  1 
ATOM   5123 C  C   . GLU   B 1 400 ? -14.93787 -4.92432  -83.18389 1.000 17.74585 ? 400 GLU   B C   1 
ATOM   5124 O  O   . GLU   B 1 400 ? -13.82284 -4.52132  -83.53562 1.000 23.51205 ? 400 GLU   B O   1 
ATOM   5125 C  CB  . GLU   B 1 400 ? -15.01548 -7.21496  -82.07985 1.000 28.74216 ? 400 GLU   B CB  1 
ATOM   5126 C  CG  . GLU   B 1 400 ? -15.33262 -7.99535  -80.79261 1.000 29.93795 ? 400 GLU   B CG  1 
ATOM   5127 C  CD  . GLU   B 1 400 ? -15.13215 -9.49480  -80.91739 1.000 36.24711 ? 400 GLU   B CD  1 
ATOM   5128 O  OE1 . GLU   B 1 400 ? -14.85815 -10.14762 -79.88124 1.000 27.83272 ? 400 GLU   B OE1 1 
ATOM   5129 O  OE2 . GLU   B 1 400 ? -15.23849 -10.01411 -82.04934 1.000 37.54862 ? 400 GLU   B OE2 1 
ATOM   5130 N  N   . ASP   B 1 401 ? -16.03988 -4.67558  -83.89291 1.000 23.54720 ? 401 ASP   B N   1 
ATOM   5131 C  CA  . ASP   B 1 401 ? -15.99865 -3.80681  -85.06856 1.000 19.72985 ? 401 ASP   B CA  1 
ATOM   5132 C  C   . ASP   B 1 401 ? -15.56492 -2.39251  -84.69369 1.000 22.20109 ? 401 ASP   B C   1 
ATOM   5133 O  O   . ASP   B 1 401 ? -14.81593 -1.74025  -85.42803 1.000 20.13639 ? 401 ASP   B O   1 
ATOM   5134 C  CB  . ASP   B 1 401 ? -17.37232 -3.74803  -85.73096 1.000 24.07951 ? 401 ASP   B CB  1 
ATOM   5135 C  CG  . ASP   B 1 401 ? -17.78141 -5.05558  -86.37918 1.000 26.37995 ? 401 ASP   B CG  1 
ATOM   5136 O  OD1 . ASP   B 1 401 ? -16.93579 -5.96625  -86.50055 1.000 20.74106 ? 401 ASP   B OD1 1 
ATOM   5137 O  OD2 . ASP   B 1 401 ? -18.95994 -5.14777  -86.78534 1.000 22.05705 ? 401 ASP   B OD2 1 
ATOM   5138 N  N   . ASN   B 1 402 ? -16.07498 -1.88666  -83.57111 1.000 19.60882 ? 402 ASN   B N   1 
ATOM   5139 C  CA  . ASN   B 1 402 ? -15.80233 -0.51185  -83.18457 1.000 22.14620 ? 402 ASN   B CA  1 
ATOM   5140 C  C   . ASN   B 1 402 ? -14.37274 -0.35059  -82.70677 1.000 18.58779 ? 402 ASN   B C   1 
ATOM   5141 O  O   . ASN   B 1 402 ? -13.74777 0.68600   -82.96923 1.000 15.03777 ? 402 ASN   B O   1 
ATOM   5142 C  CB  . ASN   B 1 402 ? -16.79176 -0.06616  -82.10917 1.000 18.59606 ? 402 ASN   B CB  1 
ATOM   5143 C  CG  . ASN   B 1 402 ? -18.18275 0.14877   -82.66107 1.000 23.04134 ? 402 ASN   B CG  1 
ATOM   5144 O  OD1 . ASN   B 1 402 ? -18.36114 0.31778   -83.87218 1.000 19.97088 ? 402 ASN   B OD1 1 
ATOM   5145 N  ND2 . ASN   B 1 402 ? -19.17381 0.19117   -81.77765 1.000 18.40320 ? 402 ASN   B ND2 1 
ATOM   5146 N  N   . ARG   B 1 403 ? -13.84092 -1.37133  -82.02522 1.000 16.30956 ? 403 ARG   B N   1 
ATOM   5147 C  CA  . ARG   B 1 403 ? -12.43584 -1.36584  -81.63735 1.000 17.05882 ? 403 ARG   B CA  1 
ATOM   5148 C  C   . ARG   B 1 403 ? -11.53144 -1.34409  -82.86520 1.000 20.84541 ? 403 ARG   B C   1 
ATOM   5149 O  O   . ARG   B 1 403 ? -10.53521 -0.61016  -82.90148 1.000 17.05811 ? 403 ARG   B O   1 
ATOM   5150 C  CB  . ARG   B 1 403 ? -12.13450 -2.58345  -80.76060 1.000 20.05279 ? 403 ARG   B CB  1 
ATOM   5151 C  CG  . ARG   B 1 403 ? -10.78346 -2.56803  -80.06215 1.000 17.94782 ? 403 ARG   B CG  1 
ATOM   5152 C  CD  . ARG   B 1 403 ? -9.69819  -3.19674  -80.90556 1.000 19.28149 ? 403 ARG   B CD  1 
ATOM   5153 N  NE  . ARG   B 1 403 ? -8.49457  -3.46477  -80.12271 1.000 22.55996 ? 403 ARG   B NE  1 
ATOM   5154 C  CZ  . ARG   B 1 403 ? -7.26921  -3.51474  -80.64134 1.000 21.77684 ? 403 ARG   B CZ  1 
ATOM   5155 N  NH1 . ARG   B 1 403 ? -7.08907  -3.29392  -81.93674 1.000 23.86956 ? 403 ARG   B NH1 1 
ATOM   5156 N  NH2 . ARG   B 1 403 ? -6.22611  -3.77202  -79.86871 1.000 22.90702 ? 403 ARG   B NH2 1 
ATOM   5157 N  N   . GLU   B 1 404 ? -11.85665 -2.14853  -83.87767 1.000 19.12445 ? 404 GLU   B N   1 
ATOM   5158 C  CA  . GLU   B 1 404 ? -11.03810 -2.17240  -85.08853 1.000 20.12078 ? 404 GLU   B CA  1 
ATOM   5159 C  C   . GLU   B 1 404 ? -11.04691 -0.81694  -85.78643 1.000 16.58537 ? 404 GLU   B C   1 
ATOM   5160 O  O   . GLU   B 1 404 ? -10.00411 -0.34774  -86.25804 1.000 18.07733 ? 404 GLU   B O   1 
ATOM   5161 C  CB  . GLU   B 1 404 ? -11.53597 -3.26939  -86.02775 1.000 19.42563 ? 404 GLU   B CB  1 
ATOM   5162 C  CG  . GLU   B 1 404 ? -10.90039 -3.29276  -87.40982 1.000 19.67065 ? 404 GLU   B CG  1 
ATOM   5163 C  CD  . GLU   B 1 404 ? -11.43860 -4.44764  -88.25492 1.000 27.78292 ? 404 GLU   B CD  1 
ATOM   5164 O  OE1 . GLU   B 1 404 ? -10.64987 -5.35205  -88.59864 1.000 31.38406 ? 404 GLU   B OE1 1 
ATOM   5165 O  OE2 . GLU   B 1 404 ? -12.65909 -4.46393  -88.55000 1.000 18.38851 ? 404 GLU   B OE2 1 
ATOM   5166 N  N   . TRP   B 1 405 ? -12.21585 -0.17469  -85.84900 1.000 16.19194 ? 405 TRP   B N   1 
ATOM   5167 C  CA  . TRP   B 1 405 ? -12.32533 1.13894   -86.47345 1.000 17.50675 ? 405 TRP   B CA  1 
ATOM   5168 C  C   . TRP   B 1 405 ? -11.47778 2.17161   -85.73921 1.000 17.39947 ? 405 TRP   B C   1 
ATOM   5169 O  O   . TRP   B 1 405 ? -10.64303 2.85138   -86.35179 1.000 15.99704 ? 405 TRP   B O   1 
ATOM   5170 C  CB  . TRP   B 1 405 ? -13.78890 1.58103   -86.51432 1.000 16.87873 ? 405 TRP   B CB  1 
ATOM   5171 C  CG  . TRP   B 1 405 ? -13.95158 2.89439   -87.22120 1.000 20.33805 ? 405 TRP   B CG  1 
ATOM   5172 C  CD1 . TRP   B 1 405 ? -14.06487 3.09036   -88.57374 1.000 18.72623 ? 405 TRP   B CD1 1 
ATOM   5173 C  CD2 . TRP   B 1 405 ? -13.98555 4.19709   -86.62263 1.000 15.92007 ? 405 TRP   B CD2 1 
ATOM   5174 N  NE1 . TRP   B 1 405 ? -14.17272 4.43113   -88.85039 1.000 21.13360 ? 405 TRP   B NE1 1 
ATOM   5175 C  CE2 . TRP   B 1 405 ? -14.12140 5.13300   -87.67177 1.000 19.33872 ? 405 TRP   B CE2 1 
ATOM   5176 C  CE3 . TRP   B 1 405 ? -13.91188 4.66549   -85.30220 1.000 16.85840 ? 405 TRP   B CE3 1 
ATOM   5177 C  CZ2 . TRP   B 1 405 ? -14.20325 6.50620   -87.44367 1.000 19.97017 ? 405 TRP   B CZ2 1 
ATOM   5178 C  CZ3 . TRP   B 1 405 ? -13.97245 6.04651   -85.08145 1.000 18.86220 ? 405 TRP   B CZ3 1 
ATOM   5179 C  CH2 . TRP   B 1 405 ? -14.11661 6.94208   -86.15050 1.000 19.99011 ? 405 TRP   B CH2 1 
ATOM   5180 N  N   . TYR   B 1 406 ? -11.68289 2.30089   -84.41574 1.000 16.96419 ? 406 TYR   B N   1 
ATOM   5181 C  CA  . TYR   B 1 406 ? -10.90720 3.24889   -83.62038 1.000 16.50402 ? 406 TYR   B CA  1 
ATOM   5182 C  C   . TYR   B 1 406 ? -9.41157  3.02657   -83.79792 1.000 19.15574 ? 406 TYR   B C   1 
ATOM   5183 O  O   . TYR   B 1 406 ? -8.65215  3.98946   -83.98031 1.000 18.21361 ? 406 TYR   B O   1 
ATOM   5184 C  CB  . TYR   B 1 406 ? -11.30037 3.16657   -82.13557 1.000 14.37215 ? 406 TYR   B CB  1 
ATOM   5185 C  CG  . TYR   B 1 406 ? -12.23045 4.29677   -81.72810 1.000 16.44616 ? 406 TYR   B CG  1 
ATOM   5186 C  CD1 . TYR   B 1 406 ? -11.75359 5.60438   -81.54447 1.000 14.66396 ? 406 TYR   B CD1 1 
ATOM   5187 C  CD2 . TYR   B 1 406 ? -13.58814 4.06949   -81.55129 1.000 13.48487 ? 406 TYR   B CD2 1 
ATOM   5188 C  CE1 . TYR   B 1 406 ? -12.63457 6.65850   -81.18472 1.000 16.41451 ? 406 TYR   B CE1 1 
ATOM   5189 C  CE2 . TYR   B 1 406 ? -14.45349 5.09500   -81.19359 1.000 12.95357 ? 406 TYR   B CE2 1 
ATOM   5190 C  CZ  . TYR   B 1 406 ? -13.98055 6.38184   -81.01811 1.000 13.38416 ? 406 TYR   B CZ  1 
ATOM   5191 O  OH  . TYR   B 1 406 ? -14.88803 7.35136   -80.65671 1.000 16.30428 ? 406 TYR   B OH  1 
ATOM   5192 N  N   . GLN   B 1 407 ? -8.97051  1.76236   -83.77471 1.000 16.32511 ? 407 GLN   B N   1 
ATOM   5193 C  CA  . GLN   B 1 407 ? -7.56594  1.47067   -84.04346 1.000 15.78183 ? 407 GLN   B CA  1 
ATOM   5194 C  C   . GLN   B 1 407 ? -7.13743  1.96145   -85.42725 1.000 20.48760 ? 407 GLN   B C   1 
ATOM   5195 O  O   . GLN   B 1 407 ? -5.98962  2.38325   -85.60814 1.000 19.33388 ? 407 GLN   B O   1 
ATOM   5196 C  CB  . GLN   B 1 407 ? -7.30504  -0.02980  -83.92002 1.000 19.20437 ? 407 GLN   B CB  1 
ATOM   5197 C  CG  . GLN   B 1 407 ? -5.84637  -0.43336  -84.08240 1.000 18.17217 ? 407 GLN   B CG  1 
ATOM   5198 C  CD  . GLN   B 1 407 ? -4.95860  0.17619   -83.02484 1.000 25.06632 ? 407 GLN   B CD  1 
ATOM   5199 O  OE1 . GLN   B 1 407 ? -5.36347  0.29308   -81.86386 1.000 19.59579 ? 407 GLN   B OE1 1 
ATOM   5200 N  NE2 . GLN   B 1 407 ? -3.73960  0.58494   -83.41655 1.000 19.39571 ? 407 GLN   B NE2 1 
ATOM   5201 N  N   . SER   B 1 408 ? -8.02869  1.90275   -86.41879 1.000 16.61396 ? 408 SER   B N   1 
ATOM   5202 C  CA  . SER   B 1 408 ? -7.62871  2.30413   -87.75989 1.000 17.57059 ? 408 SER   B CA  1 
ATOM   5203 C  C   . SER   B 1 408 ? -7.47844  3.81810   -87.89727 1.000 16.52000 ? 408 SER   B C   1 
ATOM   5204 O  O   . SER   B 1 408 ? -6.82451  4.27102   -88.84449 1.000 17.56871 ? 408 SER   B O   1 
ATOM   5205 C  CB  . SER   B 1 408 ? -8.62088  1.76269   -88.79658 1.000 14.96492 ? 408 SER   B CB  1 
ATOM   5206 O  OG  . SER   B 1 408 ? -9.84699  2.47539   -88.79063 1.000 14.23310 ? 408 SER   B OG  1 
ATOM   5207 N  N   . THR   B 1 409 ? -8.05078  4.60588   -86.97626 1.000 15.24930 ? 409 THR   B N   1 
ATOM   5208 C  CA  . THR   B 1 409 ? -7.84716  6.05526   -86.97296 1.000 17.26962 ? 409 THR   B CA  1 
ATOM   5209 C  C   . THR   B 1 409 ? -6.49922  6.45762   -86.38387 1.000 16.06737 ? 409 THR   B C   1 
ATOM   5210 O  O   . THR   B 1 409 ? -6.15904  7.64504   -86.39302 1.000 14.16403 ? 409 THR   B O   1 
ATOM   5211 C  CB  . THR   B 1 409 ? -8.96386  6.77884   -86.20240 1.000 16.56710 ? 409 THR   B CB  1 
ATOM   5212 O  OG1 . THR   B 1 409 ? -8.88549  6.45776   -84.81040 1.000 20.40507 ? 409 THR   B OG1 1 
ATOM   5213 C  CG2 . THR   B 1 409 ? -10.35483 6.41754   -86.72828 1.000 12.91345 ? 409 THR   B CG2 1 
ATOM   5214 N  N   . ILE   B 1 410 ? -5.72701  5.50827   -85.87932 1.000 16.39779 ? 410 ILE   B N   1 
ATOM   5215 C  CA  . ILE   B 1 410 ? -4.41185  5.81050   -85.35195 1.000 20.76988 ? 410 ILE   B CA  1 
ATOM   5216 C  C   . ILE   B 1 410 ? -3.39644  5.59432   -86.45830 1.000 19.84401 ? 410 ILE   B C   1 
ATOM   5217 O  O   . ILE   B 1 410 ? -3.15893  4.44717   -86.83807 1.000 20.23155 ? 410 ILE   B O   1 
ATOM   5218 C  CB  . ILE   B 1 410 ? -4.09336  4.92844   -84.12442 1.000 21.62960 ? 410 ILE   B CB  1 
ATOM   5219 C  CG1 . ILE   B 1 410 ? -5.17056  5.11353   -83.04830 1.000 19.05695 ? 410 ILE   B CG1 1 
ATOM   5220 C  CG2 . ILE   B 1 410 ? -2.67747  5.20506   -83.62030 1.000 18.26985 ? 410 ILE   B CG2 1 
ATOM   5221 C  CD1 . ILE   B 1 410 ? -5.22125  3.99340   -82.02766 1.000 19.50016 ? 410 ILE   B CD1 1 
HETATM 5222 ZN ZN  . ZN    C 2 .   ? -19.16024 3.54078   -28.67372 1.000 16.41186 ? 601 ZN    A ZN  1 
HETATM 5223 MG MG  . MG    D 3 .   ? -20.82415 3.54445   -31.97200 1.000 7.74175  ? 602 MG    A MG  1 
HETATM 5224 C  C5  . A1D8P E 4 .   ? -23.04403 -1.06740  -28.96942 1.000 23.68860 ? 603 A1D8P A C5  1 
HETATM 5225 C  C4  . A1D8P E 4 .   ? -23.97491 -1.34954  -29.96261 1.000 31.79164 ? 603 A1D8P A C4  1 
HETATM 5226 O  O3  . A1D8P E 4 .   ? -25.12193 -1.93310  -29.43875 1.000 35.69848 ? 603 A1D8P A O3  1 
HETATM 5227 C  C2  . A1D8P E 4 .   ? -24.95776 -2.04832  -28.08135 1.000 29.00677 ? 603 A1D8P A C2  1 
HETATM 5228 O  O1  . A1D8P E 4 .   ? -25.81284 -2.55470  -27.40245 1.000 39.83024 ? 603 A1D8P A O1  1 
HETATM 5229 C  C6  . A1D8P E 4 .   ? -23.62913 -1.50169  -27.71589 1.000 27.19773 ? 603 A1D8P A C6  1 
HETATM 5230 C  C7  . A1D8P E 4 .   ? -22.96121 -1.28752  -26.57023 1.000 22.72485 ? 603 A1D8P A C7  1 
HETATM 5231 C  C8  . A1D8P E 4 .   ? -23.21607 -1.72098  -25.19296 1.000 18.52757 ? 603 A1D8P A C8  1 
HETATM 5232 C  C9  . A1D8P E 4 .   ? -22.33506 -1.29827  -24.19981 1.000 16.28255 ? 603 A1D8P A C9  1 
HETATM 5233 C  C10 . A1D8P E 4 .   ? -22.45637 -1.73737  -22.89350 1.000 16.73810 ? 603 A1D8P A C10 1 
HETATM 5234 C  C11 . A1D8P E 4 .   ? -23.47425 -2.61582  -22.55606 1.000 15.25369 ? 603 A1D8P A C11 1 
HETATM 5235 O  O12 . A1D8P E 4 .   ? -23.63299 -3.15176  -21.29732 1.000 15.46428 ? 603 A1D8P A O12 1 
HETATM 5236 C  C13 . A1D8P E 4 .   ? -22.89241 -2.69593  -20.24020 1.000 18.48380 ? 603 A1D8P A C13 1 
HETATM 5237 F  F14 . A1D8P E 4 .   ? -21.58707 -3.00888  -20.39637 1.000 17.71120 ? 603 A1D8P A F14 1 
HETATM 5238 F  F15 . A1D8P E 4 .   ? -23.01480 -1.36149  -20.06308 1.000 15.52867 ? 603 A1D8P A F15 1 
HETATM 5239 C  C16 . A1D8P E 4 .   ? -24.37681 -3.05230  -23.54618 1.000 19.75339 ? 603 A1D8P A C16 1 
HETATM 5240 O  O17 . A1D8P E 4 .   ? -25.32777 -3.96024  -23.14383 1.000 21.00992 ? 603 A1D8P A O17 1 
HETATM 5241 C  C18 . A1D8P E 4 .   ? -26.52652 -4.12072  -23.95595 1.000 23.83063 ? 603 A1D8P A C18 1 
HETATM 5242 C  C19 . A1D8P E 4 .   ? -26.29575 -5.09735  -25.10220 1.000 23.85341 ? 603 A1D8P A C19 1 
HETATM 5243 C  C20 . A1D8P E 4 .   ? -26.44355 -6.45929  -24.45250 1.000 27.37016 ? 603 A1D8P A C20 1 
HETATM 5244 C  C21 . A1D8P E 4 .   ? -27.43266 -6.28687  -23.31149 1.000 25.66995 ? 603 A1D8P A C21 1 
HETATM 5245 C  C22 . A1D8P E 4 .   ? -27.57369 -4.79143  -23.05483 1.000 22.75344 ? 603 A1D8P A C22 1 
HETATM 5246 C  C23 . A1D8P E 4 .   ? -24.24220 -2.60163  -24.84942 1.000 17.73139 ? 603 A1D8P A C23 1 
HETATM 5247 C  C24 . A1D8P E 4 .   ? -21.81265 -0.53532  -29.35690 1.000 28.70288 ? 603 A1D8P A C24 1 
HETATM 5248 C  C25 . A1D8P E 4 .   ? -21.54597 -0.29698  -30.69644 1.000 22.07571 ? 603 A1D8P A C25 1 
HETATM 5249 C  C26 . A1D8P E 4 .   ? -22.50712 -0.58746  -31.66383 1.000 27.92111 ? 603 A1D8P A C26 1 
HETATM 5250 O  O27 . A1D8P E 4 .   ? -22.26894 -0.35483  -32.98480 1.000 23.84133 ? 603 A1D8P A O27 1 
HETATM 5251 C  C28 . A1D8P E 4 .   ? -23.73975 -1.11862  -31.29761 1.000 33.61527 ? 603 A1D8P A C28 1 
HETATM 5252 ZN ZN  . ZN    F 2 .   ? -23.15838 5.90859   -65.33554 1.000 19.82845 ? 601 ZN    B ZN  1 
HETATM 5253 MG MG  . MG    G 3 .   ? -21.66211 6.44155   -62.02871 1.000 11.74578 ? 602 MG    B MG  1 
HETATM 5254 C  C5  . A1D8P H 4 .   ? -17.13087 5.89074   -65.65658 1.000 36.67643 ? 603 A1D8P B C5  1 
HETATM 5255 C  C4  . A1D8P H 4 .   ? -16.18049 6.20418   -64.69374 1.000 34.77772 ? 603 A1D8P B C4  1 
HETATM 5256 O  O3  . A1D8P H 4 .   ? -15.00045 6.65823   -65.25791 1.000 41.64919 ? 603 A1D8P B O3  1 
HETATM 5257 C  C2  . A1D8P H 4 .   ? -15.15542 6.63991   -66.62399 1.000 36.94664 ? 603 A1D8P B C2  1 
HETATM 5258 O  O1  . A1D8P H 4 .   ? -14.23337 6.93393   -67.34231 1.000 45.28493 ? 603 A1D8P B O1  1 
HETATM 5259 C  C6  . A1D8P H 4 .   ? -16.51030 6.15524   -66.94546 1.000 30.22474 ? 603 A1D8P B C6  1 
HETATM 5260 C  C7  . A1D8P H 4 .   ? -17.21563 5.96990   -68.07579 1.000 25.75872 ? 603 A1D8P B C7  1 
HETATM 5261 C  C8  . A1D8P H 4 .   ? -16.85189 6.09659   -69.49267 1.000 26.11877 ? 603 A1D8P B C8  1 
HETATM 5262 C  C9  . A1D8P H 4 .   ? -17.85511 5.99872   -70.45650 1.000 21.52230 ? 603 A1D8P B C9  1 
HETATM 5263 C  C10 . A1D8P H 4 .   ? -17.56216 6.05445   -71.80894 1.000 17.45790 ? 603 A1D8P B C10 1 
HETATM 5264 C  C11 . A1D8P H 4 .   ? -16.24879 6.21055   -72.22261 1.000 20.53765 ? 603 A1D8P B C11 1 
HETATM 5265 O  O12 . A1D8P H 4 .   ? -15.84252 6.22014   -73.53496 1.000 22.56841 ? 603 A1D8P B O12 1 
HETATM 5266 C  C13 . A1D8P H 4 .   ? -16.76815 6.17447   -74.53492 1.000 19.44734 ? 603 A1D8P B C13 1 
HETATM 5267 F  F14 . A1D8P H 4 .   ? -17.70924 7.12776   -74.40789 1.000 22.32668 ? 603 A1D8P B F14 1 
HETATM 5268 F  F15 . A1D8P H 4 .   ? -17.35838 4.95676   -74.53280 1.000 24.83836 ? 603 A1D8P B F15 1 
HETATM 5269 C  C16 . A1D8P H 4 .   ? -15.22245 6.31402   -71.26604 1.000 23.02166 ? 603 A1D8P B C16 1 
HETATM 5270 O  O17 . A1D8P H 4 .   ? -13.95185 6.45072   -71.76320 1.000 23.41895 ? 603 A1D8P B O17 1 
HETATM 5271 C  C18 . A1D8P H 4 .   ? -12.93980 7.06101   -70.91830 1.000 26.48069 ? 603 A1D8P B C18 1 
HETATM 5272 C  C19 . A1D8P H 4 .   ? -12.18920 5.99434   -70.12233 1.000 28.71299 ? 603 A1D8P B C19 1 
HETATM 5273 C  C20 . A1D8P H 4 .   ? -10.98875 5.62170   -70.98916 1.000 27.65725 ? 603 A1D8P B C20 1 
HETATM 5274 C  C21 . A1D8P H 4 .   ? -11.04880 6.50196   -72.21964 1.000 26.38976 ? 603 A1D8P B C21 1 
HETATM 5275 C  C22 . A1D8P H 4 .   ? -11.90750 7.69132   -71.83323 1.000 28.99850 ? 603 A1D8P B C22 1 
HETATM 5276 C  C23 . A1D8P H 4 .   ? -15.52855 6.25709   -69.91568 1.000 26.06436 ? 603 A1D8P B C23 1 
HETATM 5277 C  C24 . A1D8P H 4 .   ? -18.32691 5.31534   -65.23706 1.000 35.24713 ? 603 A1D8P B C24 1 
HETATM 5278 C  C25 . A1D8P H 4 .   ? -18.54984 5.07468   -63.88886 1.000 30.76553 ? 603 A1D8P B C25 1 
HETATM 5279 C  C26 . A1D8P H 4 .   ? -17.57692 5.40777   -62.94822 1.000 33.80553 ? 603 A1D8P B C26 1 
HETATM 5280 O  O27 . A1D8P H 4 .   ? -17.77554 5.13159   -61.62480 1.000 25.78553 ? 603 A1D8P B O27 1 
HETATM 5281 C  C28 . A1D8P H 4 .   ? -16.37761 5.98539   -63.34569 1.000 36.34176 ? 603 A1D8P B C28 1 
HETATM 5282 O  O   . HOH   I 5 .   ? -0.389    19.718    -44.170   1.000 27.30626 ? 701 HOH   A O   1 
HETATM 5283 O  O   . HOH   I 5 .   ? 4.70125   13.53657  -43.35054 1.000 47.83658 ? 702 HOH   A O   1 
HETATM 5284 O  O   . HOH   I 5 .   ? -21.51019 15.63339  -43.68147 1.000 38.81533 ? 703 HOH   A O   1 
HETATM 5285 O  O   . HOH   I 5 .   ? -12.33470 11.24886  -5.99712  1.000 31.47508 ? 704 HOH   A O   1 
HETATM 5286 O  O   . HOH   I 5 .   ? -18.233   23.008    -17.718   1.000 33.78193 ? 705 HOH   A O   1 
HETATM 5287 O  O   . HOH   I 5 .   ? -39.70716 0.74468   -22.86583 1.000 32.75819 ? 706 HOH   A O   1 
HETATM 5288 O  O   . HOH   I 5 .   ? -27.07884 12.27465  -20.40118 1.000 18.25237 ? 707 HOH   A O   1 
HETATM 5289 O  O   . HOH   I 5 .   ? 2.30657   -8.64394  -40.31259 1.000 25.64744 ? 708 HOH   A O   1 
HETATM 5290 O  O   . HOH   I 5 .   ? -9.68117  -5.28126  -40.95508 1.000 17.30784 ? 709 HOH   A O   1 
HETATM 5291 O  O   . HOH   I 5 .   ? 2.311     16.153    -48.989   1.000 56.62567 ? 710 HOH   A O   1 
HETATM 5292 O  O   . HOH   I 5 .   ? 3.97982   18.57200  -23.21663 1.000 54.69158 ? 711 HOH   A O   1 
HETATM 5293 O  O   . HOH   I 5 .   ? -3.87023  17.51888  -7.28199  1.000 33.45999 ? 712 HOH   A O   1 
HETATM 5294 O  O   . HOH   I 5 .   ? -35.99459 8.18362   -36.89687 1.000 25.89052 ? 713 HOH   A O   1 
HETATM 5295 O  O   . HOH   I 5 .   ? -30.42792 13.55068  -28.18137 1.000 32.37839 ? 714 HOH   A O   1 
HETATM 5296 O  O   . HOH   I 5 .   ? 2.12707   22.93561  -29.06595 1.000 26.21277 ? 715 HOH   A O   1 
HETATM 5297 O  O   . HOH   I 5 .   ? -5.92488  27.48693  -35.74896 1.000 20.31738 ? 716 HOH   A O   1 
HETATM 5298 O  O   . HOH   I 5 .   ? -1.965    22.058    -47.351   1.000 32.88482 ? 717 HOH   A O   1 
HETATM 5299 O  O   . HOH   I 5 .   ? -28.83530 -1.70050  -14.70791 1.000 21.53766 ? 718 HOH   A O   1 
HETATM 5300 O  O   . HOH   I 5 .   ? 2.71986   -0.71099  -26.36789 1.000 20.49565 ? 719 HOH   A O   1 
HETATM 5301 O  O   . HOH   I 5 .   ? -20.80690 1.76218   -33.24816 1.000 9.84343  ? 720 HOH   A O   1 
HETATM 5302 O  O   . HOH   I 5 .   ? -3.81397  -13.59766 -20.66101 1.000 23.16036 ? 721 HOH   A O   1 
HETATM 5303 O  O   . HOH   I 5 .   ? -25.22387 -1.64573  -36.69960 1.000 12.73479 ? 722 HOH   A O   1 
HETATM 5304 O  O   . HOH   I 5 .   ? -31.11611 12.68664  -45.96903 1.000 28.47772 ? 723 HOH   A O   1 
HETATM 5305 O  O   . HOH   I 5 .   ? -32.65634 -1.59401  -32.45081 1.000 28.36125 ? 724 HOH   A O   1 
HETATM 5306 O  O   . HOH   I 5 .   ? -12.36284 5.61494   -18.48029 1.000 14.31095 ? 725 HOH   A O   1 
HETATM 5307 O  O   . HOH   I 5 .   ? -9.28419  28.50056  -37.87340 1.000 28.06185 ? 726 HOH   A O   1 
HETATM 5308 O  O   . HOH   I 5 .   ? -10.20398 25.22937  -38.74058 1.000 23.01822 ? 727 HOH   A O   1 
HETATM 5309 O  O   . HOH   I 5 .   ? -15.09841 0.87507   -20.17828 1.000 8.85397  ? 728 HOH   A O   1 
HETATM 5310 O  O   . HOH   I 5 .   ? -10.18486 -5.06072  -12.05153 1.000 29.62981 ? 729 HOH   A O   1 
HETATM 5311 O  O   . HOH   I 5 .   ? -17.57181 -1.33200  -31.47788 1.000 13.18901 ? 730 HOH   A O   1 
HETATM 5312 O  O   . HOH   I 5 .   ? -12.75981 3.93541   -16.36919 1.000 18.65935 ? 731 HOH   A O   1 
HETATM 5313 O  O   . HOH   I 5 .   ? -7.43635  -8.02881  -41.72716 1.000 31.45377 ? 732 HOH   A O   1 
HETATM 5314 O  O   . HOH   I 5 .   ? -15.28613 -16.74731 -24.81727 1.000 27.14243 ? 733 HOH   A O   1 
HETATM 5315 O  O   . HOH   I 5 .   ? -6.60249  -15.76173 -23.25274 1.000 27.73914 ? 734 HOH   A O   1 
HETATM 5316 O  O   . HOH   I 5 .   ? -18.15597 4.82489   -45.70507 1.000 17.49397 ? 735 HOH   A O   1 
HETATM 5317 O  O   . HOH   I 5 .   ? -24.19664 1.05763   -34.13887 1.000 19.35708 ? 736 HOH   A O   1 
HETATM 5318 O  O   . HOH   I 5 .   ? -1.94198  6.61915   -14.32187 1.000 21.63942 ? 737 HOH   A O   1 
HETATM 5319 O  O   . HOH   I 5 .   ? -17.32246 -12.60766 -9.11990  1.000 27.66129 ? 738 HOH   A O   1 
HETATM 5320 O  O   . HOH   I 5 .   ? -18.15548 3.60061   -21.88984 1.000 8.04239  ? 739 HOH   A O   1 
HETATM 5321 O  O   . HOH   I 5 .   ? -23.66781 13.26300  -41.69385 1.000 14.28849 ? 740 HOH   A O   1 
HETATM 5322 O  O   . HOH   I 5 .   ? -23.05953 14.89965  -20.94307 1.000 20.91400 ? 741 HOH   A O   1 
HETATM 5323 O  O   . HOH   I 5 .   ? -18.46543 -12.89181 -30.60149 1.000 20.38528 ? 742 HOH   A O   1 
HETATM 5324 O  O   . HOH   I 5 .   ? 3.23367   0.95898   -30.13606 1.000 19.58389 ? 743 HOH   A O   1 
HETATM 5325 O  O   . HOH   I 5 .   ? -18.23178 -7.58742  -42.06893 1.000 30.56623 ? 744 HOH   A O   1 
HETATM 5326 O  O   . HOH   I 5 .   ? -32.54997 6.30763   -26.35707 1.000 22.00458 ? 745 HOH   A O   1 
HETATM 5327 O  O   . HOH   I 5 .   ? -34.94983 11.63171  -39.60548 1.000 24.51677 ? 746 HOH   A O   1 
HETATM 5328 O  O   . HOH   I 5 .   ? 5.26374   2.60148   -30.58648 1.000 27.33180 ? 747 HOH   A O   1 
HETATM 5329 O  O   . HOH   I 5 .   ? -17.461   7.649     -7.739    1.000 31.58883 ? 748 HOH   A O   1 
HETATM 5330 O  O   . HOH   I 5 .   ? -0.79721  8.66451   -47.37739 1.000 26.09959 ? 749 HOH   A O   1 
HETATM 5331 O  O   . HOH   I 5 .   ? -3.36999  -11.22938 -22.03119 1.000 19.75924 ? 750 HOH   A O   1 
HETATM 5332 O  O   . HOH   I 5 .   ? -22.60478 14.35246  -23.99179 1.000 15.39401 ? 751 HOH   A O   1 
HETATM 5333 O  O   . HOH   I 5 .   ? 2.61073   5.97889   -39.82850 1.000 17.21911 ? 752 HOH   A O   1 
HETATM 5334 O  O   . HOH   I 5 .   ? -10.13232 -8.22584  -37.53691 1.000 22.99405 ? 753 HOH   A O   1 
HETATM 5335 O  O   . HOH   I 5 .   ? -23.25522 19.92917  -19.29999 1.000 32.44447 ? 754 HOH   A O   1 
HETATM 5336 O  O   . HOH   I 5 .   ? 5.95368   -2.04757  -36.36126 1.000 24.37725 ? 755 HOH   A O   1 
HETATM 5337 O  O   . HOH   I 5 .   ? -9.33671  7.69316   -11.30509 1.000 25.06826 ? 756 HOH   A O   1 
HETATM 5338 O  O   . HOH   I 5 .   ? -11.65926 1.77427   -10.22498 1.000 18.85151 ? 757 HOH   A O   1 
HETATM 5339 O  O   . HOH   I 5 .   ? -19.33999 4.09175   -33.40641 1.000 10.70812 ? 758 HOH   A O   1 
HETATM 5340 O  O   . HOH   I 5 .   ? -24.30020 11.87441  -28.57907 1.000 12.52206 ? 759 HOH   A O   1 
HETATM 5341 O  O   . HOH   I 5 .   ? -13.08559 -0.32163  -33.91859 1.000 17.67543 ? 760 HOH   A O   1 
HETATM 5342 O  O   . HOH   I 5 .   ? 3.32454   9.08575   -29.68066 1.000 24.69721 ? 761 HOH   A O   1 
HETATM 5343 O  O   . HOH   I 5 .   ? -39.60718 8.54594   -32.59397 1.000 35.65657 ? 762 HOH   A O   1 
HETATM 5344 O  O   . HOH   I 5 .   ? -16.81890 -14.52101 -35.43122 1.000 26.38242 ? 763 HOH   A O   1 
HETATM 5345 O  O   . HOH   I 5 .   ? -26.69167 0.45189   -34.12805 1.000 19.43496 ? 764 HOH   A O   1 
HETATM 5346 O  O   . HOH   I 5 .   ? -4.84887  9.49604   -8.44977  1.000 28.30358 ? 765 HOH   A O   1 
HETATM 5347 O  O   . HOH   I 5 .   ? -23.14152 3.83270   -46.18320 1.000 20.32903 ? 766 HOH   A O   1 
HETATM 5348 O  O   . HOH   I 5 .   ? -31.03683 6.11958   -49.26605 1.000 16.83042 ? 767 HOH   A O   1 
HETATM 5349 O  O   . HOH   I 5 .   ? -16.02667 25.95475  -32.09869 1.000 28.46145 ? 768 HOH   A O   1 
HETATM 5350 O  O   . HOH   I 5 .   ? -20.14787 18.49765  -22.20122 1.000 26.45608 ? 769 HOH   A O   1 
HETATM 5351 O  O   . HOH   I 5 .   ? -0.15286  3.15645   -40.95509 1.000 28.06537 ? 770 HOH   A O   1 
HETATM 5352 O  O   . HOH   I 5 .   ? -24.67864 -1.25331  -40.48753 1.000 18.16682 ? 771 HOH   A O   1 
HETATM 5353 O  O   . HOH   I 5 .   ? -20.10371 0.48236   -26.10095 1.000 13.12980 ? 772 HOH   A O   1 
HETATM 5354 O  O   . HOH   I 5 .   ? -14.89900 -7.75444  -10.34636 1.000 21.69226 ? 773 HOH   A O   1 
HETATM 5355 O  O   . HOH   I 5 .   ? -19.42946 2.84325   -30.53528 1.000 9.73250  ? 774 HOH   A O   1 
HETATM 5356 O  O   . HOH   I 5 .   ? -30.99979 2.70824   -27.98419 1.000 24.13185 ? 775 HOH   A O   1 
HETATM 5357 O  O   . HOH   I 5 .   ? 7.92201   15.28984  -29.12215 1.000 30.77738 ? 776 HOH   A O   1 
HETATM 5358 O  O   . HOH   I 5 .   ? -16.20238 28.32910  -36.68814 1.000 28.98237 ? 777 HOH   A O   1 
HETATM 5359 O  O   . HOH   I 5 .   ? -3.34852  -4.91204  -22.70776 1.000 26.12297 ? 778 HOH   A O   1 
HETATM 5360 O  O   . HOH   I 5 .   ? -0.94063  2.08196   -19.18949 1.000 17.84889 ? 779 HOH   A O   1 
HETATM 5361 O  O   . HOH   I 5 .   ? -11.83695 17.95803  -42.04149 1.000 20.11894 ? 780 HOH   A O   1 
HETATM 5362 O  O   . HOH   I 5 .   ? -12.25532 2.87566   -7.51326  1.000 23.63060 ? 781 HOH   A O   1 
HETATM 5363 O  O   . HOH   I 5 .   ? -22.13655 1.63508   -9.56116  1.000 21.18383 ? 782 HOH   A O   1 
HETATM 5364 O  O   . HOH   I 5 .   ? -0.89569  20.03741  -36.40402 1.000 15.45683 ? 783 HOH   A O   1 
HETATM 5365 O  O   . HOH   I 5 .   ? -21.28446 16.90746  -24.08900 1.000 15.57996 ? 784 HOH   A O   1 
HETATM 5366 O  O   . HOH   I 5 .   ? -15.13132 2.92732   -17.37909 1.000 8.76813  ? 785 HOH   A O   1 
HETATM 5367 O  O   . HOH   I 5 .   ? -3.55126  15.46991  -47.48248 1.000 28.70450 ? 786 HOH   A O   1 
HETATM 5368 O  O   . HOH   I 5 .   ? -7.09201  9.38168   -47.05559 1.000 15.66640 ? 787 HOH   A O   1 
HETATM 5369 O  O   . HOH   I 5 .   ? -10.63111 2.69259   -17.38577 1.000 16.67257 ? 788 HOH   A O   1 
HETATM 5370 O  O   . HOH   I 5 .   ? -22.34611 4.20001   -33.26427 1.000 8.85151  ? 789 HOH   A O   1 
HETATM 5371 O  O   . HOH   I 5 .   ? -10.66282 -7.70183  -40.15834 1.000 21.62362 ? 790 HOH   A O   1 
HETATM 5372 O  O   . HOH   I 5 .   ? 2.34559   3.53247   -26.53018 1.000 23.03918 ? 791 HOH   A O   1 
HETATM 5373 O  O   . HOH   I 5 .   ? -31.20345 -1.50610  -47.30108 1.000 19.62015 ? 792 HOH   A O   1 
HETATM 5374 O  O   . HOH   I 5 .   ? -33.96274 3.60768   -44.56112 1.000 16.43096 ? 793 HOH   A O   1 
HETATM 5375 O  O   . HOH   I 5 .   ? -14.47792 27.57211  -32.72075 1.000 26.87931 ? 794 HOH   A O   1 
HETATM 5376 O  O   . HOH   I 5 .   ? -19.80497 23.85635  -30.12137 1.000 24.86848 ? 795 HOH   A O   1 
HETATM 5377 O  O   . HOH   I 5 .   ? -34.14726 -6.68313  -15.13578 1.000 29.90106 ? 796 HOH   A O   1 
HETATM 5378 O  O   . HOH   I 5 .   ? -26.68988 -2.11655  -11.71960 1.000 17.63160 ? 797 HOH   A O   1 
HETATM 5379 O  O   . HOH   I 5 .   ? -7.35727  -5.46299  -42.26648 1.000 25.18025 ? 798 HOH   A O   1 
HETATM 5380 O  O   . HOH   I 5 .   ? -4.28117  -7.26616  -17.54658 1.000 25.13200 ? 799 HOH   A O   1 
HETATM 5381 O  O   . HOH   I 5 .   ? 3.51394   17.65194  -26.27879 1.000 24.60903 ? 800 HOH   A O   1 
HETATM 5382 O  O   . HOH   I 5 .   ? -25.04163 2.50071   -31.55715 1.000 12.62078 ? 801 HOH   A O   1 
HETATM 5383 O  O   . HOH   I 5 .   ? -28.41268 -5.84417  -11.71929 1.000 23.49100 ? 802 HOH   A O   1 
HETATM 5384 O  O   . HOH   I 5 .   ? -17.55718 -4.42664  -34.77595 1.000 12.05331 ? 803 HOH   A O   1 
HETATM 5385 O  O   . HOH   I 5 .   ? -12.47368 -8.76405  -10.69180 1.000 26.74966 ? 804 HOH   A O   1 
HETATM 5386 O  O   . HOH   I 5 .   ? -1.81144  13.05904  -15.04155 1.000 35.38895 ? 805 HOH   A O   1 
HETATM 5387 O  O   . HOH   I 5 .   ? -24.57582 17.67729  -31.62075 1.000 15.63192 ? 806 HOH   A O   1 
HETATM 5388 O  O   . HOH   I 5 .   ? 8.07660   10.30024  -30.72408 1.000 31.90307 ? 807 HOH   A O   1 
HETATM 5389 O  O   . HOH   I 5 .   ? -25.42413 -16.60109 -21.79684 1.000 25.97407 ? 808 HOH   A O   1 
HETATM 5390 O  O   . HOH   I 5 .   ? -9.25407  8.86676   -5.84887  1.000 27.53938 ? 809 HOH   A O   1 
HETATM 5391 O  O   . HOH   I 5 .   ? -11.48494 -17.38873 -37.58159 1.000 27.86984 ? 810 HOH   A O   1 
HETATM 5392 O  O   . HOH   I 5 .   ? -7.16108  -16.85524 -18.76793 1.000 32.71831 ? 811 HOH   A O   1 
HETATM 5393 O  O   . HOH   I 5 .   ? -22.13202 15.91475  -41.61547 1.000 24.95098 ? 812 HOH   A O   1 
HETATM 5394 O  O   . HOH   I 5 .   ? -18.73664 -1.63791  -23.27945 1.000 10.70100 ? 813 HOH   A O   1 
HETATM 5395 O  O   . HOH   I 5 .   ? -28.60650 3.03555   -28.70867 1.000 20.66611 ? 814 HOH   A O   1 
HETATM 5396 O  O   . HOH   I 5 .   ? 0.60008   26.51337  -36.31108 1.000 23.79542 ? 815 HOH   A O   1 
HETATM 5397 O  O   . HOH   I 5 .   ? -28.45337 -5.71697  -19.72018 1.000 20.32422 ? 816 HOH   A O   1 
HETATM 5398 O  O   . HOH   I 5 .   ? -23.85139 -1.55531  -48.50234 1.000 21.94459 ? 817 HOH   A O   1 
HETATM 5399 O  O   . HOH   I 5 .   ? -7.30236  25.74345  -37.23264 1.000 25.78245 ? 818 HOH   A O   1 
HETATM 5400 O  O   . HOH   I 5 .   ? -31.40518 1.72359   -15.93754 1.000 22.95757 ? 819 HOH   A O   1 
HETATM 5401 O  O   . HOH   I 5 .   ? -20.77016 2.37304   -27.91894 1.000 8.89256  ? 820 HOH   A O   1 
HETATM 5402 O  O   . HOH   I 5 .   ? -0.18372  -11.86891 -41.80621 1.000 31.03185 ? 821 HOH   A O   1 
HETATM 5403 O  O   . HOH   I 5 .   ? -19.58875 -9.39418  -39.14559 1.000 26.66674 ? 822 HOH   A O   1 
HETATM 5404 O  O   . HOH   I 5 .   ? 7.70406   8.03554   -30.19894 1.000 34.80453 ? 823 HOH   A O   1 
HETATM 5405 O  O   . HOH   I 5 .   ? -26.59795 0.89694   -40.61209 1.000 10.31867 ? 824 HOH   A O   1 
HETATM 5406 O  O   . HOH   I 5 .   ? -20.20112 2.41363   -44.92781 1.000 22.12029 ? 825 HOH   A O   1 
HETATM 5407 O  O   . HOH   I 5 .   ? 1.24861   -2.16761  -46.49817 1.000 29.81789 ? 826 HOH   A O   1 
HETATM 5408 O  O   . HOH   I 5 .   ? 5.83023   -4.80579  -35.64138 1.000 24.60729 ? 827 HOH   A O   1 
HETATM 5409 O  O   . HOH   I 5 .   ? -5.81169  -11.70384 -39.86564 1.000 28.01899 ? 828 HOH   A O   1 
HETATM 5410 O  O   . HOH   I 5 .   ? -28.85464 -1.74811  -35.16276 1.000 14.34803 ? 829 HOH   A O   1 
HETATM 5411 O  O   . HOH   I 5 .   ? 7.08380   -3.27213  -43.87882 1.000 42.56991 ? 830 HOH   A O   1 
HETATM 5412 O  O   . HOH   I 5 .   ? -13.53425 -0.34707  -41.66926 1.000 18.38010 ? 831 HOH   A O   1 
HETATM 5413 O  O   . HOH   I 5 .   ? -26.58082 -17.01323 -6.32951  1.000 35.46382 ? 832 HOH   A O   1 
HETATM 5414 O  O   . HOH   I 5 .   ? -30.96652 8.03558   -23.21786 1.000 23.27805 ? 833 HOH   A O   1 
HETATM 5415 O  O   . HOH   I 5 .   ? -21.52069 -9.02630  -36.06035 1.000 20.54077 ? 834 HOH   A O   1 
HETATM 5416 O  O   . HOH   I 5 .   ? 3.07918   7.92499   -27.58101 1.000 21.80792 ? 835 HOH   A O   1 
HETATM 5417 O  O   . HOH   I 5 .   ? 3.13183   20.13305  -24.76063 1.000 23.50942 ? 836 HOH   A O   1 
HETATM 5418 O  O   . HOH   I 5 .   ? 1.45619   2.12985   -29.14966 1.000 24.17135 ? 837 HOH   A O   1 
HETATM 5419 O  O   . HOH   I 5 .   ? -28.02990 12.86250  -34.39087 1.000 22.59486 ? 838 HOH   A O   1 
HETATM 5420 O  O   . HOH   I 5 .   ? -33.56010 -7.28972  -21.54771 1.000 39.26194 ? 839 HOH   A O   1 
HETATM 5421 O  O   . HOH   I 5 .   ? 1.41841   -11.14296 -35.77542 1.000 31.41241 ? 840 HOH   A O   1 
HETATM 5422 O  O   . HOH   I 5 .   ? -20.72823 11.39183  -13.92480 1.000 26.57907 ? 841 HOH   A O   1 
HETATM 5423 O  O   . HOH   I 5 .   ? -20.56727 6.26894   -46.78840 1.000 25.39566 ? 842 HOH   A O   1 
HETATM 5424 O  O   . HOH   I 5 .   ? 4.62997   8.97975   -37.12599 1.000 18.27831 ? 843 HOH   A O   1 
HETATM 5425 O  O   . HOH   I 5 .   ? -22.38934 9.74685   -13.25970 1.000 22.22156 ? 844 HOH   A O   1 
HETATM 5426 O  O   . HOH   I 5 .   ? -22.39768 2.80939   -30.75707 1.000 9.23462  ? 845 HOH   A O   1 
HETATM 5427 O  O   . HOH   I 5 .   ? -1.56289  -4.25086  -46.71412 1.000 23.63501 ? 846 HOH   A O   1 
HETATM 5428 O  O   . HOH   I 5 .   ? -31.40005 12.77852  -29.83415 1.000 31.70202 ? 847 HOH   A O   1 
HETATM 5429 O  O   . HOH   I 5 .   ? -39.24850 9.45808   -44.29362 1.000 34.09548 ? 848 HOH   A O   1 
HETATM 5430 O  O   . HOH   I 5 .   ? -19.06486 0.18121   -43.98482 1.000 26.58592 ? 849 HOH   A O   1 
HETATM 5431 O  O   . HOH   I 5 .   ? -32.13220 11.17200  -38.74892 1.000 18.14002 ? 850 HOH   A O   1 
HETATM 5432 O  O   . HOH   I 5 .   ? -11.04355 15.76895  -43.20999 1.000 21.27231 ? 851 HOH   A O   1 
HETATM 5433 O  O   . HOH   I 5 .   ? -25.69280 -5.27307  -29.13303 1.000 34.67952 ? 852 HOH   A O   1 
HETATM 5434 O  O   . HOH   I 5 .   ? 6.98429   7.45469   -35.13341 1.000 31.00363 ? 853 HOH   A O   1 
HETATM 5435 O  O   . HOH   I 5 .   ? 1.19987   5.23229   -41.18999 1.000 31.95994 ? 854 HOH   A O   1 
HETATM 5436 O  O   . HOH   I 5 .   ? -33.19515 -13.14434 -11.34162 1.000 36.96706 ? 855 HOH   A O   1 
HETATM 5437 O  O   . HOH   I 5 .   ? -24.86720 -19.18663 -22.48615 1.000 33.33352 ? 856 HOH   A O   1 
HETATM 5438 O  O   . HOH   I 5 .   ? -14.81521 -16.09062 -34.46923 1.000 24.69016 ? 857 HOH   A O   1 
HETATM 5439 O  O   . HOH   I 5 .   ? 0.70222   -11.34851 -37.88869 1.000 27.41990 ? 858 HOH   A O   1 
HETATM 5440 O  O   . HOH   I 5 .   ? -30.78770 13.22193  -48.27869 1.000 33.16836 ? 859 HOH   A O   1 
HETATM 5441 O  O   . HOH   I 5 .   ? -22.70957 -9.66322  -33.53888 1.000 36.11970 ? 860 HOH   A O   1 
HETATM 5442 O  O   . HOH   I 5 .   ? 1.08535   0.99272   -42.69602 1.000 25.33667 ? 861 HOH   A O   1 
HETATM 5443 O  O   . HOH   I 5 .   ? -26.24280 14.41190  -42.18071 1.000 24.10046 ? 862 HOH   A O   1 
HETATM 5444 O  O   . HOH   I 5 .   ? -8.36873  14.77855  -42.27258 1.000 26.76107 ? 863 HOH   A O   1 
HETATM 5445 O  O   . HOH   I 5 .   ? -16.69622 -9.16818  -8.11500  1.000 33.29913 ? 864 HOH   A O   1 
HETATM 5446 O  O   . HOH   I 5 .   ? -13.73908 -17.65542 -36.08881 1.000 25.49369 ? 865 HOH   A O   1 
HETATM 5447 O  O   . HOH   I 5 .   ? -31.70448 -0.91865  -15.75195 1.000 27.88526 ? 866 HOH   A O   1 
HETATM 5448 O  O   . HOH   I 5 .   ? -14.46565 13.19867  -6.25990  1.000 26.33881 ? 867 HOH   A O   1 
HETATM 5449 O  O   . HOH   J 5 .   ? -25.20806 9.17385   -81.59497 1.000 48.22705 ? 701 HOH   B O   1 
HETATM 5450 O  O   . HOH   J 5 .   ? -26.66162 12.91097  -81.46908 1.000 53.25849 ? 702 HOH   B O   1 
HETATM 5451 O  O   . HOH   J 5 .   ? -47.55063 15.44677  -83.89385 1.000 46.88931 ? 703 HOH   B O   1 
HETATM 5452 O  O   . HOH   J 5 .   ? -42.80868 15.22094  -85.36304 1.000 54.44815 ? 704 HOH   B O   1 
HETATM 5453 O  O   . HOH   J 5 .   ? -14.259   -2.761    -88.039   1.000 23.84722 ? 705 HOH   B O   1 
HETATM 5454 O  O   . HOH   J 5 .   ? -35.20359 20.23005  -66.05487 1.000 23.91499 ? 706 HOH   B O   1 
HETATM 5455 O  O   . HOH   J 5 .   ? -20.19380 5.12804   -61.15664 1.000 11.59397 ? 707 HOH   B O   1 
HETATM 5456 O  O   . HOH   J 5 .   ? -46.07203 7.34474   -49.89249 1.000 36.78644 ? 708 HOH   B O   1 
HETATM 5457 O  O   . HOH   J 5 .   ? -10.10981 11.65112  -61.42613 1.000 23.76455 ? 709 HOH   B O   1 
HETATM 5458 O  O   . HOH   J 5 .   ? -14.80477 20.06875  -55.17806 1.000 30.06201 ? 710 HOH   B O   1 
HETATM 5459 O  O   . HOH   J 5 .   ? -38.35222 -2.31377  -80.16894 1.000 34.58267 ? 711 HOH   B O   1 
HETATM 5460 O  O   . HOH   J 5 .   ? -28.87849 3.63753   -77.80567 1.000 29.59054 ? 712 HOH   B O   1 
HETATM 5461 O  O   . HOH   J 5 .   ? -23.07087 5.55823   -60.62376 1.000 10.47139 ? 713 HOH   B O   1 
HETATM 5462 O  O   . HOH   J 5 .   ? -9.58894  8.43144   -46.90450 1.000 12.92332 ? 714 HOH   B O   1 
HETATM 5463 O  O   . HOH   J 5 .   ? -33.61944 -2.77521  -47.37044 1.000 21.25938 ? 715 HOH   B O   1 
HETATM 5464 O  O   . HOH   J 5 .   ? -30.20156 3.85914   -75.41839 1.000 20.76648 ? 716 HOH   B O   1 
HETATM 5465 O  O   . HOH   J 5 .   ? -44.16477 11.26405  -52.02373 1.000 29.66346 ? 717 HOH   B O   1 
HETATM 5466 O  O   . HOH   J 5 .   ? -14.41020 5.61304   -57.96391 1.000 18.02215 ? 718 HOH   B O   1 
HETATM 5467 O  O   . HOH   J 5 .   ? -24.64688 2.86691   -74.53479 1.000 17.06949 ? 719 HOH   B O   1 
HETATM 5468 O  O   . HOH   J 5 .   ? -23.11157 -9.61591  -85.78335 1.000 32.30702 ? 720 HOH   B O   1 
HETATM 5469 O  O   . HOH   J 5 .   ? -17.40050 7.12552   -59.95912 1.000 22.64965 ? 721 HOH   B O   1 
HETATM 5470 O  O   . HOH   J 5 .   ? -24.50128 6.61295   -72.03782 1.000 13.03992 ? 722 HOH   B O   1 
HETATM 5471 O  O   . HOH   J 5 .   ? -26.04822 12.97077  -50.37951 1.000 14.14238 ? 723 HOH   B O   1 
HETATM 5472 O  O   . HOH   J 5 .   ? -20.45595 5.22569   -68.45074 1.000 17.76365 ? 724 HOH   B O   1 
HETATM 5473 O  O   . HOH   J 5 .   ? -16.49925 2.10103   -51.80641 1.000 22.75154 ? 725 HOH   B O   1 
HETATM 5474 O  O   . HOH   J 5 .   ? -16.63195 12.57620  -64.81788 1.000 20.94939 ? 726 HOH   B O   1 
HETATM 5475 O  O   . HOH   J 5 .   ? -23.56735 -2.09131  -61.38651 1.000 24.57365 ? 727 HOH   B O   1 
HETATM 5476 O  O   . HOH   J 5 .   ? -14.12558 9.87711   -81.02644 1.000 18.14811 ? 728 HOH   B O   1 
HETATM 5477 O  O   . HOH   J 5 .   ? -19.64973 7.28578   -87.41158 1.000 25.81798 ? 729 HOH   B O   1 
HETATM 5478 O  O   . HOH   J 5 .   ? -4.57102  -1.14180  -76.20109 1.000 28.81347 ? 730 HOH   B O   1 
HETATM 5479 O  O   . HOH   J 5 .   ? -11.29182 -5.59046  -66.86694 1.000 22.45483 ? 731 HOH   B O   1 
HETATM 5480 O  O   . HOH   J 5 .   ? -20.15519 1.02004   -63.67228 1.000 15.14276 ? 732 HOH   B O   1 
HETATM 5481 O  O   . HOH   J 5 .   ? -36.21354 -18.15409 -63.14635 1.000 44.37104 ? 733 HOH   B O   1 
HETATM 5482 O  O   . HOH   J 5 .   ? -14.91020 14.47189  -65.13599 1.000 21.50171 ? 734 HOH   B O   1 
HETATM 5483 O  O   . HOH   J 5 .   ? -20.61917 17.39682  -46.12937 1.000 34.42796 ? 735 HOH   B O   1 
HETATM 5484 O  O   . HOH   J 5 .   ? -23.31538 21.16377  -63.05671 1.000 21.88654 ? 736 HOH   B O   1 
HETATM 5485 O  O   . HOH   J 5 .   ? -11.89174 13.92563  -48.64260 1.000 15.71968 ? 737 HOH   B O   1 
HETATM 5486 O  O   . HOH   J 5 .   ? -21.19165 -6.71115  -86.82605 1.000 27.96297 ? 738 HOH   B O   1 
HETATM 5487 O  O   . HOH   J 5 .   ? -22.93808 -3.30295  -53.90467 1.000 25.28393 ? 739 HOH   B O   1 
HETATM 5488 O  O   . HOH   J 5 .   ? -22.15284 5.31603   -63.54916 1.000 13.58866 ? 740 HOH   B O   1 
HETATM 5489 O  O   . HOH   J 5 .   ? -14.65338 4.89276   -54.44223 1.000 20.44058 ? 741 HOH   B O   1 
HETATM 5490 O  O   . HOH   J 5 .   ? -4.54135  1.77100   -76.90169 1.000 28.80031 ? 742 HOH   B O   1 
HETATM 5491 O  O   . HOH   J 5 .   ? -19.31938 18.62751  -69.18652 1.000 23.26916 ? 743 HOH   B O   1 
HETATM 5492 O  O   . HOH   J 5 .   ? -3.65449  1.27583   -86.59467 1.000 20.58557 ? 744 HOH   B O   1 
HETATM 5493 O  O   . HOH   J 5 .   ? -11.93723 9.76329   -83.17065 1.000 27.12186 ? 745 HOH   B O   1 
HETATM 5494 O  O   . HOH   J 5 .   ? -21.09304 7.96981   -60.47504 1.000 11.44149 ? 746 HOH   B O   1 
HETATM 5495 O  O   . HOH   J 5 .   ? -10.91803 -11.32892 -63.78402 1.000 31.39961 ? 747 HOH   B O   1 
HETATM 5496 O  O   . HOH   J 5 .   ? -29.29094 0.84557   -77.01292 1.000 30.11672 ? 748 HOH   B O   1 
HETATM 5497 O  O   . HOH   J 5 .   ? -20.04293 3.05692   -49.66845 1.000 22.58256 ? 749 HOH   B O   1 
HETATM 5498 O  O   . HOH   J 5 .   ? -46.75730 1.54864   -55.95732 1.000 28.00590 ? 750 HOH   B O   1 
HETATM 5499 O  O   . HOH   J 5 .   ? -15.28662 12.51093  -43.65271 1.000 14.98613 ? 751 HOH   B O   1 
HETATM 5500 O  O   . HOH   J 5 .   ? -25.86121 15.24297  -63.64866 1.000 15.15859 ? 752 HOH   B O   1 
HETATM 5501 O  O   . HOH   J 5 .   ? -20.26738 3.19807   -71.70151 1.000 14.55523 ? 753 HOH   B O   1 
HETATM 5502 O  O   . HOH   J 5 .   ? -17.81901 -1.41747  -61.15492 1.000 14.99027 ? 754 HOH   B O   1 
HETATM 5503 O  O   . HOH   J 5 .   ? -14.808   5.341     -91.431   1.000 17.36996 ? 755 HOH   B O   1 
HETATM 5504 O  O   . HOH   J 5 .   ? -34.29569 -10.64794 -54.73477 1.000 25.53599 ? 756 HOH   B O   1 
HETATM 5505 O  O   . HOH   J 5 .   ? -37.52474 7.66450   -49.72230 1.000 25.57591 ? 757 HOH   B O   1 
HETATM 5506 O  O   . HOH   J 5 .   ? -26.44608 4.67014   -76.75529 1.000 21.35091 ? 758 HOH   B O   1 
HETATM 5507 O  O   . HOH   J 5 .   ? -15.16470 7.41614   -53.46821 1.000 12.15340 ? 759 HOH   B O   1 
HETATM 5508 O  O   . HOH   J 5 .   ? -33.43064 -5.17364  -46.12670 1.000 33.74928 ? 760 HOH   B O   1 
HETATM 5509 O  O   . HOH   J 5 .   ? -7.50337  -1.35882  -87.20380 1.000 20.69005 ? 761 HOH   B O   1 
HETATM 5510 O  O   . HOH   J 5 .   ? -18.29568 9.02358   -62.20827 1.000 15.17102 ? 762 HOH   B O   1 
HETATM 5511 O  O   . HOH   J 5 .   ? -15.34610 8.50437   -60.01911 1.000 19.75560 ? 763 HOH   B O   1 
HETATM 5512 O  O   . HOH   J 5 .   ? -10.94060 8.60151   -75.19971 1.000 19.20285 ? 764 HOH   B O   1 
HETATM 5513 O  O   . HOH   J 5 .   ? -12.65219 4.64697   -66.62409 1.000 37.25025 ? 765 HOH   B O   1 
HETATM 5514 O  O   . HOH   J 5 .   ? -21.12802 6.53444   -66.17602 1.000 12.96943 ? 766 HOH   B O   1 
HETATM 5515 O  O   . HOH   J 5 .   ? -23.49781 17.29439  -57.27456 1.000 28.69967 ? 767 HOH   B O   1 
HETATM 5516 O  O   . HOH   J 5 .   ? -12.26221 -4.03709  -57.85477 1.000 31.07537 ? 768 HOH   B O   1 
HETATM 5517 O  O   . HOH   J 5 .   ? -16.57152 18.34175  -66.07692 1.000 21.24088 ? 769 HOH   B O   1 
HETATM 5518 O  O   . HOH   J 5 .   ? -41.37521 -7.48753  -67.29732 1.000 30.35961 ? 770 HOH   B O   1 
HETATM 5519 O  O   . HOH   J 5 .   ? -18.27212 -8.47169  -85.84398 1.000 28.35667 ? 771 HOH   B O   1 
HETATM 5520 O  O   . HOH   J 5 .   ? -6.74481  12.99554  -79.51492 1.000 27.42765 ? 772 HOH   B O   1 
HETATM 5521 O  O   . HOH   J 5 .   ? -22.92764 2.64927   -48.36361 1.000 22.27197 ? 773 HOH   B O   1 
HETATM 5522 O  O   . HOH   J 5 .   ? -17.98168 20.96052  -51.90384 1.000 29.60136 ? 774 HOH   B O   1 
HETATM 5523 O  O   . HOH   J 5 .   ? -14.44497 2.40996   -46.28268 1.000 25.10134 ? 775 HOH   B O   1 
HETATM 5524 O  O   . HOH   J 5 .   ? -35.88089 -18.97134 -72.44566 1.000 46.61094 ? 776 HOH   B O   1 
HETATM 5525 O  O   . HOH   J 5 .   ? -26.92097 -9.35369  -79.07710 1.000 33.32700 ? 777 HOH   B O   1 
HETATM 5526 O  O   . HOH   J 5 .   ? -28.96060 17.26998  -71.11284 1.000 33.98198 ? 778 HOH   B O   1 
HETATM 5527 O  O   . HOH   J 5 .   ? -22.51032 5.54989   -47.15388 1.000 28.45069 ? 779 HOH   B O   1 
HETATM 5528 O  O   . HOH   J 5 .   ? -22.75048 -6.33584  -52.99209 1.000 30.85631 ? 780 HOH   B O   1 
HETATM 5529 O  O   . HOH   J 5 .   ? -51.93191 4.31812   -63.62105 1.000 39.11060 ? 781 HOH   B O   1 
HETATM 5530 O  O   . HOH   J 5 .   ? -23.08460 3.53778   -86.86756 1.000 26.89041 ? 782 HOH   B O   1 
HETATM 5531 O  O   . HOH   J 5 .   ? -40.95238 15.69435  -68.14590 1.000 37.17627 ? 783 HOH   B O   1 
HETATM 5532 O  O   . HOH   J 5 .   ? -32.14794 18.84794  -66.48790 1.000 32.57444 ? 784 HOH   B O   1 
HETATM 5533 O  O   . HOH   J 5 .   ? -11.56376 -1.95174  -60.41675 1.000 25.92391 ? 785 HOH   B O   1 
HETATM 5534 O  O   . HOH   J 5 .   ? -39.03985 -16.93087 -61.85220 1.000 35.69621 ? 786 HOH   B O   1 
HETATM 5535 O  O   . HOH   J 5 .   ? -27.67071 -22.01985 -58.90942 1.000 33.30704 ? 787 HOH   B O   1 
HETATM 5536 O  O   . HOH   J 5 .   ? -19.40300 18.37317  -52.88125 1.000 20.41287 ? 788 HOH   B O   1 
HETATM 5537 O  O   . HOH   J 5 .   ? -36.19347 4.88051   -49.36570 1.000 25.82226 ? 789 HOH   B O   1 
HETATM 5538 O  O   . HOH   J 5 .   ? -7.69568  8.97130   -52.07237 1.000 33.82673 ? 790 HOH   B O   1 
HETATM 5539 O  O   . HOH   J 5 .   ? -20.26986 7.47338   -63.22554 1.000 11.42551 ? 791 HOH   B O   1 
HETATM 5540 O  O   . HOH   J 5 .   ? -29.75292 19.58938  -61.73660 1.000 23.33526 ? 792 HOH   B O   1 
HETATM 5541 O  O   . HOH   J 5 .   ? -12.18224 8.52331   -59.34220 1.000 18.69057 ? 793 HOH   B O   1 
HETATM 5542 O  O   . HOH   J 5 .   ? -29.86601 -18.76744 -74.80539 1.000 36.47828 ? 794 HOH   B O   1 
HETATM 5543 O  O   . HOH   J 5 .   ? -37.28305 -7.71635  -47.51084 1.000 30.55329 ? 795 HOH   B O   1 
HETATM 5544 O  O   . HOH   J 5 .   ? -3.09300  12.67937  -69.13318 1.000 36.27227 ? 796 HOH   B O   1 
HETATM 5545 O  O   . HOH   J 5 .   ? -5.33596  -0.23698  -87.73453 1.000 25.34000 ? 797 HOH   B O   1 
HETATM 5546 O  O   . HOH   J 5 .   ? -15.95899 10.96049  -82.91524 1.000 32.37646 ? 798 HOH   B O   1 
HETATM 5547 O  O   . HOH   J 5 .   ? -20.58634 -2.92481  -54.28321 1.000 27.93234 ? 799 HOH   B O   1 
HETATM 5548 O  O   . HOH   J 5 .   ? -31.22974 -29.61806 -72.10917 1.000 47.85367 ? 800 HOH   B O   1 
HETATM 5549 O  O   . HOH   J 5 .   ? -28.74165 -2.58831  -47.30502 1.000 22.79090 ? 801 HOH   B O   1 
HETATM 5550 O  O   . HOH   J 5 .   ? -17.377   4.765     -91.520   1.000 24.04582 ? 802 HOH   B O   1 
HETATM 5551 O  O   . HOH   J 5 .   ? -29.25854 13.68326  -50.30136 1.000 27.07781 ? 803 HOH   B O   1 
HETATM 5552 O  O   . HOH   J 5 .   ? -37.92819 2.68468   -50.69023 1.000 33.63937 ? 804 HOH   B O   1 
# 
