data_8ZQS
# 
_entry.id   8ZQS 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZQS         pdb_00008zqs 10.2210/pdb8zqs/pdb 
WWPDB D_1300048379 ?            ?                   
EMDB  EMD-60390    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-06-11 ? 
2 'EM metadata'     1 0 2025-06-11 ? 
3 'Half map'        1 0 2025-06-11 1 
4 'Half map'        1 0 2025-06-11 2 
5 Image             1 0 2025-06-11 ? 
6 'Primary map'     1 0 2025-06-11 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Half map'        repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 Image             repository 'Initial release' ? ? 
6 6 'Primary map'     repository 'Initial release' ? ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZQS 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of Cas12X with crRNA, Conformation 1' 
_pdbx_database_related.db_id          EMD-60390 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              11649008@mail.sustech.edu.cn 
_pdbx_contact_author.name_first         Xi 
_pdbx_contact_author.name_last          Zhang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-6495-2586 
# 
_audit_author.name               'Zhang, X.' 
_audit_author.pdbx_ordinal       1 
_audit_author.identifier_ORCID   ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Cryo-EM structure of Cas12X with crRNA and Target DNA, Conformation 1' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
_citation_author.citation_id        primary 
_citation_author.name               'Zhang, X.' 
_citation_author.ordinal            1 
_citation_author.identifier_ORCID   ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man Cas12X         106402.023 1 ? ? ? ? 
2 polymer man 'RNA (60-MER)' 19229.471  1 ? ? ? ? 
3 polymer man 'DNA (44-MER)' 13644.746  1 ? ? ? ? 
4 polymer man 'DNA (44-MER)' 13453.643  1 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'        no no 
;HHHHHHMPSYKSSRVLVRDVPEELVDHYERSHRVAAFFMRLLLAMRREPYSLRMRDGTEREVDLDETDDFLRSAGCEEPD
AVSDDLRSFALAVLHQDNPKKRAFLESENCVSILCLEKSASGTRYYKRPGYQLLKKAIEEEWGWDKFEASLLDERTGEVA
EKFAALSMEDWRRFFAARDPDDLGRELLKTDTREGMAAALRLRERGVFPVSVPEHLDLDSLKAAMASAAERLKSWLACNQ
RAVDEKSELRKRFEEALDGVDPEKYALFEKFAAELQQADYNVTKKLVLAVSAKFPATEPSEFKRGVEILKEDGYKPLWED
FRELGFVYLAERKWERRRGGAAVTLCDADDSPIKVRFGLTGRGRKFVLSAAGSRFLITVKLPCGDVGLTAVPSRYFWNPS
VGRTTSNSFRIEFTKRTTENRRYVGEVKEIGLVRQRGRYYFFIDYNFDPEEVSDETKVGRAFFRAPLNESRPKPKDKLTV
MGIDLGINPAFAFAVCTLGECQDGIRSPVAKMEDVSFDSTGLRGGIGSQKLHREMHNLSDRCFYGARYIRLSKKLRDRGA
LNDIEARLLEEKYIPGFRIVHIEDADERRRTVGRTVKEIKQEYKRIRHQFYLRYHTSKRDRTELISAEYFRMLFLVKNLR
NLLKSWNRYHWTTGDRERRGGNPDELKSYVRYYNNLRMDTLKKLTCAIVRTAKEHGATLVAMENIQRVDRDDEVKRRKEN
SLLSLWAPGMVLERVEQELKNEGILAWEVDPRHTSQTSCITDEFGYRSLVAKDTFYFEQDRKIHRIDADVNAAINIARRF
LTRYRSLTQLWASLLDDGRYLVNVTRQHERAYLELQTGAPAATLNPTAEASYELVGLSPEEEELAQTRIKRKKREPFYRH
EGVWLTREKHREQVHELRNQVLALGNAKIPEIRT
;
;HHHHHHMPSYKSSRVLVRDVPEELVDHYERSHRVAAFFMRLLLAMRREPYSLRMRDGTEREVDLDETDDFLRSAGCEEPD
AVSDDLRSFALAVLHQDNPKKRAFLESENCVSILCLEKSASGTRYYKRPGYQLLKKAIEEEWGWDKFEASLLDERTGEVA
EKFAALSMEDWRRFFAARDPDDLGRELLKTDTREGMAAALRLRERGVFPVSVPEHLDLDSLKAAMASAAERLKSWLACNQ
RAVDEKSELRKRFEEALDGVDPEKYALFEKFAAELQQADYNVTKKLVLAVSAKFPATEPSEFKRGVEILKEDGYKPLWED
FRELGFVYLAERKWERRRGGAAVTLCDADDSPIKVRFGLTGRGRKFVLSAAGSRFLITVKLPCGDVGLTAVPSRYFWNPS
VGRTTSNSFRIEFTKRTTENRRYVGEVKEIGLVRQRGRYYFFIDYNFDPEEVSDETKVGRAFFRAPLNESRPKPKDKLTV
MGIDLGINPAFAFAVCTLGECQDGIRSPVAKMEDVSFDSTGLRGGIGSQKLHREMHNLSDRCFYGARYIRLSKKLRDRGA
LNDIEARLLEEKYIPGFRIVHIEDADERRRTVGRTVKEIKQEYKRIRHQFYLRYHTSKRDRTELISAEYFRMLFLVKNLR
NLLKSWNRYHWTTGDRERRGGNPDELKSYVRYYNNLRMDTLKKLTCAIVRTAKEHGATLVAMENIQRVDRDDEVKRRKEN
SLLSLWAPGMVLERVEQELKNEGILAWEVDPRHTSQTSCITDEFGYRSLVAKDTFYFEQDRKIHRIDADVNAAINIARRF
LTRYRSLTQLWASLLDDGRYLVNVTRQHERAYLELQTGAPAATLNPTAEASYELVGLSPEEEELAQTRIKRKKREPFYRH
EGVWLTREKHREQVHELRNQVLALGNAKIPEIRT
;
A ? 
2 polyribonucleotide      no no GUGCUGCUGUCUCCCAGACGGGAGGCAGAACUGCACCUUCCAUCAGAGAACCUCACUGCG 
GUGCUGCUGUCUCCCAGACGGGAGGCAGAACUGCACCUUCCAUCAGAGAACCUCACUGCG B ? 
3 polydeoxyribonucleotide no no 
;(DC)(DA)(DA)(DG)(DC)(DC)(DG)(DT)(DC)(DT)(DA)(DG)(DC)(DG)(DG)(DT)(DG)(DA)(DG)(DG)
(DT)(DT)(DC)(DT)(DC)(DT)(DG)(DA)(DT)(DG)(DG)(DA)(DA)(DG)(DC)(DA)(DT)(DA)(DT)(DC)
(DG)(DT)(DA)(DG)
;
CAAGCCGTCTAGCGGTGAGGTTCTCTGATGGAAGCATATCGTAG C ? 
4 polydeoxyribonucleotide no no 
;(DC)(DT)(DA)(DC)(DG)(DA)(DT)(DA)(DT)(DG)(DC)(DT)(DT)(DC)(DC)(DA)(DT)(DC)(DA)(DG)
(DA)(DG)(DA)(DA)(DC)(DC)(DT)(DC)(DA)(DC)(DC)(DG)(DC)(DT)(DA)(DG)(DA)(DC)(DG)(DG)
(DC)(DT)(DT)(DG)
;
CTACGATATGCTTCCATCAGAGAACCTCACCGCTAGACGGCTTG D ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   HIS n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   MET n 
1 8   PRO n 
1 9   SER n 
1 10  TYR n 
1 11  LYS n 
1 12  SER n 
1 13  SER n 
1 14  ARG n 
1 15  VAL n 
1 16  LEU n 
1 17  VAL n 
1 18  ARG n 
1 19  ASP n 
1 20  VAL n 
1 21  PRO n 
1 22  GLU n 
1 23  GLU n 
1 24  LEU n 
1 25  VAL n 
1 26  ASP n 
1 27  HIS n 
1 28  TYR n 
1 29  GLU n 
1 30  ARG n 
1 31  SER n 
1 32  HIS n 
1 33  ARG n 
1 34  VAL n 
1 35  ALA n 
1 36  ALA n 
1 37  PHE n 
1 38  PHE n 
1 39  MET n 
1 40  ARG n 
1 41  LEU n 
1 42  LEU n 
1 43  LEU n 
1 44  ALA n 
1 45  MET n 
1 46  ARG n 
1 47  ARG n 
1 48  GLU n 
1 49  PRO n 
1 50  TYR n 
1 51  SER n 
1 52  LEU n 
1 53  ARG n 
1 54  MET n 
1 55  ARG n 
1 56  ASP n 
1 57  GLY n 
1 58  THR n 
1 59  GLU n 
1 60  ARG n 
1 61  GLU n 
1 62  VAL n 
1 63  ASP n 
1 64  LEU n 
1 65  ASP n 
1 66  GLU n 
1 67  THR n 
1 68  ASP n 
1 69  ASP n 
1 70  PHE n 
1 71  LEU n 
1 72  ARG n 
1 73  SER n 
1 74  ALA n 
1 75  GLY n 
1 76  CYS n 
1 77  GLU n 
1 78  GLU n 
1 79  PRO n 
1 80  ASP n 
1 81  ALA n 
1 82  VAL n 
1 83  SER n 
1 84  ASP n 
1 85  ASP n 
1 86  LEU n 
1 87  ARG n 
1 88  SER n 
1 89  PHE n 
1 90  ALA n 
1 91  LEU n 
1 92  ALA n 
1 93  VAL n 
1 94  LEU n 
1 95  HIS n 
1 96  GLN n 
1 97  ASP n 
1 98  ASN n 
1 99  PRO n 
1 100 LYS n 
1 101 LYS n 
1 102 ARG n 
1 103 ALA n 
1 104 PHE n 
1 105 LEU n 
1 106 GLU n 
1 107 SER n 
1 108 GLU n 
1 109 ASN n 
1 110 CYS n 
1 111 VAL n 
1 112 SER n 
1 113 ILE n 
1 114 LEU n 
1 115 CYS n 
1 116 LEU n 
1 117 GLU n 
1 118 LYS n 
1 119 SER n 
1 120 ALA n 
1 121 SER n 
1 122 GLY n 
1 123 THR n 
1 124 ARG n 
1 125 TYR n 
1 126 TYR n 
1 127 LYS n 
1 128 ARG n 
1 129 PRO n 
1 130 GLY n 
1 131 TYR n 
1 132 GLN n 
1 133 LEU n 
1 134 LEU n 
1 135 LYS n 
1 136 LYS n 
1 137 ALA n 
1 138 ILE n 
1 139 GLU n 
1 140 GLU n 
1 141 GLU n 
1 142 TRP n 
1 143 GLY n 
1 144 TRP n 
1 145 ASP n 
1 146 LYS n 
1 147 PHE n 
1 148 GLU n 
1 149 ALA n 
1 150 SER n 
1 151 LEU n 
1 152 LEU n 
1 153 ASP n 
1 154 GLU n 
1 155 ARG n 
1 156 THR n 
1 157 GLY n 
1 158 GLU n 
1 159 VAL n 
1 160 ALA n 
1 161 GLU n 
1 162 LYS n 
1 163 PHE n 
1 164 ALA n 
1 165 ALA n 
1 166 LEU n 
1 167 SER n 
1 168 MET n 
1 169 GLU n 
1 170 ASP n 
1 171 TRP n 
1 172 ARG n 
1 173 ARG n 
1 174 PHE n 
1 175 PHE n 
1 176 ALA n 
1 177 ALA n 
1 178 ARG n 
1 179 ASP n 
1 180 PRO n 
1 181 ASP n 
1 182 ASP n 
1 183 LEU n 
1 184 GLY n 
1 185 ARG n 
1 186 GLU n 
1 187 LEU n 
1 188 LEU n 
1 189 LYS n 
1 190 THR n 
1 191 ASP n 
1 192 THR n 
1 193 ARG n 
1 194 GLU n 
1 195 GLY n 
1 196 MET n 
1 197 ALA n 
1 198 ALA n 
1 199 ALA n 
1 200 LEU n 
1 201 ARG n 
1 202 LEU n 
1 203 ARG n 
1 204 GLU n 
1 205 ARG n 
1 206 GLY n 
1 207 VAL n 
1 208 PHE n 
1 209 PRO n 
1 210 VAL n 
1 211 SER n 
1 212 VAL n 
1 213 PRO n 
1 214 GLU n 
1 215 HIS n 
1 216 LEU n 
1 217 ASP n 
1 218 LEU n 
1 219 ASP n 
1 220 SER n 
1 221 LEU n 
1 222 LYS n 
1 223 ALA n 
1 224 ALA n 
1 225 MET n 
1 226 ALA n 
1 227 SER n 
1 228 ALA n 
1 229 ALA n 
1 230 GLU n 
1 231 ARG n 
1 232 LEU n 
1 233 LYS n 
1 234 SER n 
1 235 TRP n 
1 236 LEU n 
1 237 ALA n 
1 238 CYS n 
1 239 ASN n 
1 240 GLN n 
1 241 ARG n 
1 242 ALA n 
1 243 VAL n 
1 244 ASP n 
1 245 GLU n 
1 246 LYS n 
1 247 SER n 
1 248 GLU n 
1 249 LEU n 
1 250 ARG n 
1 251 LYS n 
1 252 ARG n 
1 253 PHE n 
1 254 GLU n 
1 255 GLU n 
1 256 ALA n 
1 257 LEU n 
1 258 ASP n 
1 259 GLY n 
1 260 VAL n 
1 261 ASP n 
1 262 PRO n 
1 263 GLU n 
1 264 LYS n 
1 265 TYR n 
1 266 ALA n 
1 267 LEU n 
1 268 PHE n 
1 269 GLU n 
1 270 LYS n 
1 271 PHE n 
1 272 ALA n 
1 273 ALA n 
1 274 GLU n 
1 275 LEU n 
1 276 GLN n 
1 277 GLN n 
1 278 ALA n 
1 279 ASP n 
1 280 TYR n 
1 281 ASN n 
1 282 VAL n 
1 283 THR n 
1 284 LYS n 
1 285 LYS n 
1 286 LEU n 
1 287 VAL n 
1 288 LEU n 
1 289 ALA n 
1 290 VAL n 
1 291 SER n 
1 292 ALA n 
1 293 LYS n 
1 294 PHE n 
1 295 PRO n 
1 296 ALA n 
1 297 THR n 
1 298 GLU n 
1 299 PRO n 
1 300 SER n 
1 301 GLU n 
1 302 PHE n 
1 303 LYS n 
1 304 ARG n 
1 305 GLY n 
1 306 VAL n 
1 307 GLU n 
1 308 ILE n 
1 309 LEU n 
1 310 LYS n 
1 311 GLU n 
1 312 ASP n 
1 313 GLY n 
1 314 TYR n 
1 315 LYS n 
1 316 PRO n 
1 317 LEU n 
1 318 TRP n 
1 319 GLU n 
1 320 ASP n 
1 321 PHE n 
1 322 ARG n 
1 323 GLU n 
1 324 LEU n 
1 325 GLY n 
1 326 PHE n 
1 327 VAL n 
1 328 TYR n 
1 329 LEU n 
1 330 ALA n 
1 331 GLU n 
1 332 ARG n 
1 333 LYS n 
1 334 TRP n 
1 335 GLU n 
1 336 ARG n 
1 337 ARG n 
1 338 ARG n 
1 339 GLY n 
1 340 GLY n 
1 341 ALA n 
1 342 ALA n 
1 343 VAL n 
1 344 THR n 
1 345 LEU n 
1 346 CYS n 
1 347 ASP n 
1 348 ALA n 
1 349 ASP n 
1 350 ASP n 
1 351 SER n 
1 352 PRO n 
1 353 ILE n 
1 354 LYS n 
1 355 VAL n 
1 356 ARG n 
1 357 PHE n 
1 358 GLY n 
1 359 LEU n 
1 360 THR n 
1 361 GLY n 
1 362 ARG n 
1 363 GLY n 
1 364 ARG n 
1 365 LYS n 
1 366 PHE n 
1 367 VAL n 
1 368 LEU n 
1 369 SER n 
1 370 ALA n 
1 371 ALA n 
1 372 GLY n 
1 373 SER n 
1 374 ARG n 
1 375 PHE n 
1 376 LEU n 
1 377 ILE n 
1 378 THR n 
1 379 VAL n 
1 380 LYS n 
1 381 LEU n 
1 382 PRO n 
1 383 CYS n 
1 384 GLY n 
1 385 ASP n 
1 386 VAL n 
1 387 GLY n 
1 388 LEU n 
1 389 THR n 
1 390 ALA n 
1 391 VAL n 
1 392 PRO n 
1 393 SER n 
1 394 ARG n 
1 395 TYR n 
1 396 PHE n 
1 397 TRP n 
1 398 ASN n 
1 399 PRO n 
1 400 SER n 
1 401 VAL n 
1 402 GLY n 
1 403 ARG n 
1 404 THR n 
1 405 THR n 
1 406 SER n 
1 407 ASN n 
1 408 SER n 
1 409 PHE n 
1 410 ARG n 
1 411 ILE n 
1 412 GLU n 
1 413 PHE n 
1 414 THR n 
1 415 LYS n 
1 416 ARG n 
1 417 THR n 
1 418 THR n 
1 419 GLU n 
1 420 ASN n 
1 421 ARG n 
1 422 ARG n 
1 423 TYR n 
1 424 VAL n 
1 425 GLY n 
1 426 GLU n 
1 427 VAL n 
1 428 LYS n 
1 429 GLU n 
1 430 ILE n 
1 431 GLY n 
1 432 LEU n 
1 433 VAL n 
1 434 ARG n 
1 435 GLN n 
1 436 ARG n 
1 437 GLY n 
1 438 ARG n 
1 439 TYR n 
1 440 TYR n 
1 441 PHE n 
1 442 PHE n 
1 443 ILE n 
1 444 ASP n 
1 445 TYR n 
1 446 ASN n 
1 447 PHE n 
1 448 ASP n 
1 449 PRO n 
1 450 GLU n 
1 451 GLU n 
1 452 VAL n 
1 453 SER n 
1 454 ASP n 
1 455 GLU n 
1 456 THR n 
1 457 LYS n 
1 458 VAL n 
1 459 GLY n 
1 460 ARG n 
1 461 ALA n 
1 462 PHE n 
1 463 PHE n 
1 464 ARG n 
1 465 ALA n 
1 466 PRO n 
1 467 LEU n 
1 468 ASN n 
1 469 GLU n 
1 470 SER n 
1 471 ARG n 
1 472 PRO n 
1 473 LYS n 
1 474 PRO n 
1 475 LYS n 
1 476 ASP n 
1 477 LYS n 
1 478 LEU n 
1 479 THR n 
1 480 VAL n 
1 481 MET n 
1 482 GLY n 
1 483 ILE n 
1 484 ASP n 
1 485 LEU n 
1 486 GLY n 
1 487 ILE n 
1 488 ASN n 
1 489 PRO n 
1 490 ALA n 
1 491 PHE n 
1 492 ALA n 
1 493 PHE n 
1 494 ALA n 
1 495 VAL n 
1 496 CYS n 
1 497 THR n 
1 498 LEU n 
1 499 GLY n 
1 500 GLU n 
1 501 CYS n 
1 502 GLN n 
1 503 ASP n 
1 504 GLY n 
1 505 ILE n 
1 506 ARG n 
1 507 SER n 
1 508 PRO n 
1 509 VAL n 
1 510 ALA n 
1 511 LYS n 
1 512 MET n 
1 513 GLU n 
1 514 ASP n 
1 515 VAL n 
1 516 SER n 
1 517 PHE n 
1 518 ASP n 
1 519 SER n 
1 520 THR n 
1 521 GLY n 
1 522 LEU n 
1 523 ARG n 
1 524 GLY n 
1 525 GLY n 
1 526 ILE n 
1 527 GLY n 
1 528 SER n 
1 529 GLN n 
1 530 LYS n 
1 531 LEU n 
1 532 HIS n 
1 533 ARG n 
1 534 GLU n 
1 535 MET n 
1 536 HIS n 
1 537 ASN n 
1 538 LEU n 
1 539 SER n 
1 540 ASP n 
1 541 ARG n 
1 542 CYS n 
1 543 PHE n 
1 544 TYR n 
1 545 GLY n 
1 546 ALA n 
1 547 ARG n 
1 548 TYR n 
1 549 ILE n 
1 550 ARG n 
1 551 LEU n 
1 552 SER n 
1 553 LYS n 
1 554 LYS n 
1 555 LEU n 
1 556 ARG n 
1 557 ASP n 
1 558 ARG n 
1 559 GLY n 
1 560 ALA n 
1 561 LEU n 
1 562 ASN n 
1 563 ASP n 
1 564 ILE n 
1 565 GLU n 
1 566 ALA n 
1 567 ARG n 
1 568 LEU n 
1 569 LEU n 
1 570 GLU n 
1 571 GLU n 
1 572 LYS n 
1 573 TYR n 
1 574 ILE n 
1 575 PRO n 
1 576 GLY n 
1 577 PHE n 
1 578 ARG n 
1 579 ILE n 
1 580 VAL n 
1 581 HIS n 
1 582 ILE n 
1 583 GLU n 
1 584 ASP n 
1 585 ALA n 
1 586 ASP n 
1 587 GLU n 
1 588 ARG n 
1 589 ARG n 
1 590 ARG n 
1 591 THR n 
1 592 VAL n 
1 593 GLY n 
1 594 ARG n 
1 595 THR n 
1 596 VAL n 
1 597 LYS n 
1 598 GLU n 
1 599 ILE n 
1 600 LYS n 
1 601 GLN n 
1 602 GLU n 
1 603 TYR n 
1 604 LYS n 
1 605 ARG n 
1 606 ILE n 
1 607 ARG n 
1 608 HIS n 
1 609 GLN n 
1 610 PHE n 
1 611 TYR n 
1 612 LEU n 
1 613 ARG n 
1 614 TYR n 
1 615 HIS n 
1 616 THR n 
1 617 SER n 
1 618 LYS n 
1 619 ARG n 
1 620 ASP n 
1 621 ARG n 
1 622 THR n 
1 623 GLU n 
1 624 LEU n 
1 625 ILE n 
1 626 SER n 
1 627 ALA n 
1 628 GLU n 
1 629 TYR n 
1 630 PHE n 
1 631 ARG n 
1 632 MET n 
1 633 LEU n 
1 634 PHE n 
1 635 LEU n 
1 636 VAL n 
1 637 LYS n 
1 638 ASN n 
1 639 LEU n 
1 640 ARG n 
1 641 ASN n 
1 642 LEU n 
1 643 LEU n 
1 644 LYS n 
1 645 SER n 
1 646 TRP n 
1 647 ASN n 
1 648 ARG n 
1 649 TYR n 
1 650 HIS n 
1 651 TRP n 
1 652 THR n 
1 653 THR n 
1 654 GLY n 
1 655 ASP n 
1 656 ARG n 
1 657 GLU n 
1 658 ARG n 
1 659 ARG n 
1 660 GLY n 
1 661 GLY n 
1 662 ASN n 
1 663 PRO n 
1 664 ASP n 
1 665 GLU n 
1 666 LEU n 
1 667 LYS n 
1 668 SER n 
1 669 TYR n 
1 670 VAL n 
1 671 ARG n 
1 672 TYR n 
1 673 TYR n 
1 674 ASN n 
1 675 ASN n 
1 676 LEU n 
1 677 ARG n 
1 678 MET n 
1 679 ASP n 
1 680 THR n 
1 681 LEU n 
1 682 LYS n 
1 683 LYS n 
1 684 LEU n 
1 685 THR n 
1 686 CYS n 
1 687 ALA n 
1 688 ILE n 
1 689 VAL n 
1 690 ARG n 
1 691 THR n 
1 692 ALA n 
1 693 LYS n 
1 694 GLU n 
1 695 HIS n 
1 696 GLY n 
1 697 ALA n 
1 698 THR n 
1 699 LEU n 
1 700 VAL n 
1 701 ALA n 
1 702 MET n 
1 703 GLU n 
1 704 ASN n 
1 705 ILE n 
1 706 GLN n 
1 707 ARG n 
1 708 VAL n 
1 709 ASP n 
1 710 ARG n 
1 711 ASP n 
1 712 ASP n 
1 713 GLU n 
1 714 VAL n 
1 715 LYS n 
1 716 ARG n 
1 717 ARG n 
1 718 LYS n 
1 719 GLU n 
1 720 ASN n 
1 721 SER n 
1 722 LEU n 
1 723 LEU n 
1 724 SER n 
1 725 LEU n 
1 726 TRP n 
1 727 ALA n 
1 728 PRO n 
1 729 GLY n 
1 730 MET n 
1 731 VAL n 
1 732 LEU n 
1 733 GLU n 
1 734 ARG n 
1 735 VAL n 
1 736 GLU n 
1 737 GLN n 
1 738 GLU n 
1 739 LEU n 
1 740 LYS n 
1 741 ASN n 
1 742 GLU n 
1 743 GLY n 
1 744 ILE n 
1 745 LEU n 
1 746 ALA n 
1 747 TRP n 
1 748 GLU n 
1 749 VAL n 
1 750 ASP n 
1 751 PRO n 
1 752 ARG n 
1 753 HIS n 
1 754 THR n 
1 755 SER n 
1 756 GLN n 
1 757 THR n 
1 758 SER n 
1 759 CYS n 
1 760 ILE n 
1 761 THR n 
1 762 ASP n 
1 763 GLU n 
1 764 PHE n 
1 765 GLY n 
1 766 TYR n 
1 767 ARG n 
1 768 SER n 
1 769 LEU n 
1 770 VAL n 
1 771 ALA n 
1 772 LYS n 
1 773 ASP n 
1 774 THR n 
1 775 PHE n 
1 776 TYR n 
1 777 PHE n 
1 778 GLU n 
1 779 GLN n 
1 780 ASP n 
1 781 ARG n 
1 782 LYS n 
1 783 ILE n 
1 784 HIS n 
1 785 ARG n 
1 786 ILE n 
1 787 ASP n 
1 788 ALA n 
1 789 ASP n 
1 790 VAL n 
1 791 ASN n 
1 792 ALA n 
1 793 ALA n 
1 794 ILE n 
1 795 ASN n 
1 796 ILE n 
1 797 ALA n 
1 798 ARG n 
1 799 ARG n 
1 800 PHE n 
1 801 LEU n 
1 802 THR n 
1 803 ARG n 
1 804 TYR n 
1 805 ARG n 
1 806 SER n 
1 807 LEU n 
1 808 THR n 
1 809 GLN n 
1 810 LEU n 
1 811 TRP n 
1 812 ALA n 
1 813 SER n 
1 814 LEU n 
1 815 LEU n 
1 816 ASP n 
1 817 ASP n 
1 818 GLY n 
1 819 ARG n 
1 820 TYR n 
1 821 LEU n 
1 822 VAL n 
1 823 ASN n 
1 824 VAL n 
1 825 THR n 
1 826 ARG n 
1 827 GLN n 
1 828 HIS n 
1 829 GLU n 
1 830 ARG n 
1 831 ALA n 
1 832 TYR n 
1 833 LEU n 
1 834 GLU n 
1 835 LEU n 
1 836 GLN n 
1 837 THR n 
1 838 GLY n 
1 839 ALA n 
1 840 PRO n 
1 841 ALA n 
1 842 ALA n 
1 843 THR n 
1 844 LEU n 
1 845 ASN n 
1 846 PRO n 
1 847 THR n 
1 848 ALA n 
1 849 GLU n 
1 850 ALA n 
1 851 SER n 
1 852 TYR n 
1 853 GLU n 
1 854 LEU n 
1 855 VAL n 
1 856 GLY n 
1 857 LEU n 
1 858 SER n 
1 859 PRO n 
1 860 GLU n 
1 861 GLU n 
1 862 GLU n 
1 863 GLU n 
1 864 LEU n 
1 865 ALA n 
1 866 GLN n 
1 867 THR n 
1 868 ARG n 
1 869 ILE n 
1 870 LYS n 
1 871 ARG n 
1 872 LYS n 
1 873 LYS n 
1 874 ARG n 
1 875 GLU n 
1 876 PRO n 
1 877 PHE n 
1 878 TYR n 
1 879 ARG n 
1 880 HIS n 
1 881 GLU n 
1 882 GLY n 
1 883 VAL n 
1 884 TRP n 
1 885 LEU n 
1 886 THR n 
1 887 ARG n 
1 888 GLU n 
1 889 LYS n 
1 890 HIS n 
1 891 ARG n 
1 892 GLU n 
1 893 GLN n 
1 894 VAL n 
1 895 HIS n 
1 896 GLU n 
1 897 LEU n 
1 898 ARG n 
1 899 ASN n 
1 900 GLN n 
1 901 VAL n 
1 902 LEU n 
1 903 ALA n 
1 904 LEU n 
1 905 GLY n 
1 906 ASN n 
1 907 ALA n 
1 908 LYS n 
1 909 ILE n 
1 910 PRO n 
1 911 GLU n 
1 912 ILE n 
1 913 ARG n 
1 914 THR n 
2 1   G   n 
2 2   U   n 
2 3   G   n 
2 4   C   n 
2 5   U   n 
2 6   G   n 
2 7   C   n 
2 8   U   n 
2 9   G   n 
2 10  U   n 
2 11  C   n 
2 12  U   n 
2 13  C   n 
2 14  C   n 
2 15  C   n 
2 16  A   n 
2 17  G   n 
2 18  A   n 
2 19  C   n 
2 20  G   n 
2 21  G   n 
2 22  G   n 
2 23  A   n 
2 24  G   n 
2 25  G   n 
2 26  C   n 
2 27  A   n 
2 28  G   n 
2 29  A   n 
2 30  A   n 
2 31  C   n 
2 32  U   n 
2 33  G   n 
2 34  C   n 
2 35  A   n 
2 36  C   n 
2 37  C   n 
2 38  U   n 
2 39  U   n 
2 40  C   n 
2 41  C   n 
2 42  A   n 
2 43  U   n 
2 44  C   n 
2 45  A   n 
2 46  G   n 
2 47  A   n 
2 48  G   n 
2 49  A   n 
2 50  A   n 
2 51  C   n 
2 52  C   n 
2 53  U   n 
2 54  C   n 
2 55  A   n 
2 56  C   n 
2 57  U   n 
2 58  G   n 
2 59  C   n 
2 60  G   n 
3 1   DC  n 
3 2   DA  n 
3 3   DA  n 
3 4   DG  n 
3 5   DC  n 
3 6   DC  n 
3 7   DG  n 
3 8   DT  n 
3 9   DC  n 
3 10  DT  n 
3 11  DA  n 
3 12  DG  n 
3 13  DC  n 
3 14  DG  n 
3 15  DG  n 
3 16  DT  n 
3 17  DG  n 
3 18  DA  n 
3 19  DG  n 
3 20  DG  n 
3 21  DT  n 
3 22  DT  n 
3 23  DC  n 
3 24  DT  n 
3 25  DC  n 
3 26  DT  n 
3 27  DG  n 
3 28  DA  n 
3 29  DT  n 
3 30  DG  n 
3 31  DG  n 
3 32  DA  n 
3 33  DA  n 
3 34  DG  n 
3 35  DC  n 
3 36  DA  n 
3 37  DT  n 
3 38  DA  n 
3 39  DT  n 
3 40  DC  n 
3 41  DG  n 
3 42  DT  n 
3 43  DA  n 
3 44  DG  n 
4 1   DC  n 
4 2   DT  n 
4 3   DA  n 
4 4   DC  n 
4 5   DG  n 
4 6   DA  n 
4 7   DT  n 
4 8   DA  n 
4 9   DT  n 
4 10  DG  n 
4 11  DC  n 
4 12  DT  n 
4 13  DT  n 
4 14  DC  n 
4 15  DC  n 
4 16  DA  n 
4 17  DT  n 
4 18  DC  n 
4 19  DA  n 
4 20  DG  n 
4 21  DA  n 
4 22  DG  n 
4 23  DA  n 
4 24  DA  n 
4 25  DC  n 
4 26  DC  n 
4 27  DT  n 
4 28  DC  n 
4 29  DA  n 
4 30  DC  n 
4 31  DC  n 
4 32  DG  n 
4 33  DC  n 
4 34  DT  n 
4 35  DA  n 
4 36  DG  n 
4 37  DA  n 
4 38  DC  n 
4 39  DG  n 
4 40  DG  n 
4 41  DC  n 
4 42  DT  n 
4 43  DT  n 
4 44  DG  n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 914 ? ? ? ? ? ? ? ? ? 'unclassified sequences' 12908 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 60  ? ? ? ? ? ? ? ? ? 'unclassified sequences' 12908 ? ? ? ? ? ? ? ? 'unclassified sequences' 
12908  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 44  ? ? ? ? ? ? ? ? ? 'unclassified sequences' 12908 ? ? ? ? ? ? ? ? 'unclassified sequences' 
12908  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
4 1 sample 'Biological sequence' 1 44  ? ? ? ? ? ? ? ? ? 'unclassified sequences' 12908 ? ? ? ? ? ? ? ? 'unclassified sequences' 
12908  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A   'RNA linking'       y "ADENOSINE-5'-MONOPHOSPHATE"         ? 'C10 H14 N5 O7 P' 347.221 
ALA 'L-peptide linking' y ALANINE                              ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                             ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                           ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                      ? 'C4 H7 N O4'      133.103 
C   'RNA linking'       y "CYTIDINE-5'-MONOPHOSPHATE"          ? 'C9 H14 N3 O8 P'  323.197 
CYS 'L-peptide linking' y CYSTEINE                             ? 'C3 H7 N O2 S'    121.158 
DA  'DNA linking'       y "2'-DEOXYADENOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O6 P' 331.222 
DC  'DNA linking'       y "2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE"  ? 'C9 H14 N3 O7 P'  307.197 
DG  'DNA linking'       y "2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O7 P' 347.221 
DT  'DNA linking'       y "THYMIDINE-5'-MONOPHOSPHATE"         ? 'C10 H15 N2 O8 P' 322.208 
G   'RNA linking'       y "GUANOSINE-5'-MONOPHOSPHATE"         ? 'C10 H14 N5 O8 P' 363.221 
GLN 'L-peptide linking' y GLUTAMINE                            ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                      ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                              ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                            ? 'C6 H10 N3 O2 1'  156.162 
ILE 'L-peptide linking' y ISOLEUCINE                           ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                              ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                               ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                           ? 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE                        ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                              ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                               ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                            ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                           ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                             ? 'C9 H11 N O3'     181.189 
U   'RNA linking'       y "URIDINE-5'-MONOPHOSPHATE"           ? 'C9 H13 N2 O9 P'  324.181 
VAL 'L-peptide linking' y VALINE                               ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   HIS 1   -5  ?   ?   ?   A . n 
A 1 2   HIS 2   -4  ?   ?   ?   A . n 
A 1 3   HIS 3   -3  ?   ?   ?   A . n 
A 1 4   HIS 4   -2  ?   ?   ?   A . n 
A 1 5   HIS 5   -1  ?   ?   ?   A . n 
A 1 6   HIS 6   0   ?   ?   ?   A . n 
A 1 7   MET 7   1   ?   ?   ?   A . n 
A 1 8   PRO 8   2   2   PRO PRO A . n 
A 1 9   SER 9   3   3   SER SER A . n 
A 1 10  TYR 10  4   4   TYR TYR A . n 
A 1 11  LYS 11  5   5   LYS LYS A . n 
A 1 12  SER 12  6   6   SER SER A . n 
A 1 13  SER 13  7   7   SER SER A . n 
A 1 14  ARG 14  8   8   ARG ARG A . n 
A 1 15  VAL 15  9   9   VAL VAL A . n 
A 1 16  LEU 16  10  10  LEU LEU A . n 
A 1 17  VAL 17  11  11  VAL VAL A . n 
A 1 18  ARG 18  12  12  ARG ARG A . n 
A 1 19  ASP 19  13  13  ASP ASP A . n 
A 1 20  VAL 20  14  ?   ?   ?   A . n 
A 1 21  PRO 21  15  ?   ?   ?   A . n 
A 1 22  GLU 22  16  ?   ?   ?   A . n 
A 1 23  GLU 23  17  ?   ?   ?   A . n 
A 1 24  LEU 24  18  ?   ?   ?   A . n 
A 1 25  VAL 25  19  ?   ?   ?   A . n 
A 1 26  ASP 26  20  ?   ?   ?   A . n 
A 1 27  HIS 27  21  ?   ?   ?   A . n 
A 1 28  TYR 28  22  ?   ?   ?   A . n 
A 1 29  GLU 29  23  ?   ?   ?   A . n 
A 1 30  ARG 30  24  24  ARG ARG A . n 
A 1 31  SER 31  25  25  SER SER A . n 
A 1 32  HIS 32  26  26  HIS HIS A . n 
A 1 33  ARG 33  27  27  ARG ARG A . n 
A 1 34  VAL 34  28  28  VAL VAL A . n 
A 1 35  ALA 35  29  29  ALA ALA A . n 
A 1 36  ALA 36  30  30  ALA ALA A . n 
A 1 37  PHE 37  31  31  PHE PHE A . n 
A 1 38  PHE 38  32  32  PHE PHE A . n 
A 1 39  MET 39  33  33  MET MET A . n 
A 1 40  ARG 40  34  34  ARG ARG A . n 
A 1 41  LEU 41  35  35  LEU LEU A . n 
A 1 42  LEU 42  36  36  LEU LEU A . n 
A 1 43  LEU 43  37  37  LEU LEU A . n 
A 1 44  ALA 44  38  38  ALA ALA A . n 
A 1 45  MET 45  39  ?   ?   ?   A . n 
A 1 46  ARG 46  40  ?   ?   ?   A . n 
A 1 47  ARG 47  41  ?   ?   ?   A . n 
A 1 48  GLU 48  42  ?   ?   ?   A . n 
A 1 49  PRO 49  43  ?   ?   ?   A . n 
A 1 50  TYR 50  44  ?   ?   ?   A . n 
A 1 51  SER 51  45  ?   ?   ?   A . n 
A 1 52  LEU 52  46  ?   ?   ?   A . n 
A 1 53  ARG 53  47  ?   ?   ?   A . n 
A 1 54  MET 54  48  ?   ?   ?   A . n 
A 1 55  ARG 55  49  ?   ?   ?   A . n 
A 1 56  ASP 56  50  ?   ?   ?   A . n 
A 1 57  GLY 57  51  ?   ?   ?   A . n 
A 1 58  THR 58  52  ?   ?   ?   A . n 
A 1 59  GLU 59  53  ?   ?   ?   A . n 
A 1 60  ARG 60  54  ?   ?   ?   A . n 
A 1 61  GLU 61  55  ?   ?   ?   A . n 
A 1 62  VAL 62  56  ?   ?   ?   A . n 
A 1 63  ASP 63  57  ?   ?   ?   A . n 
A 1 64  LEU 64  58  ?   ?   ?   A . n 
A 1 65  ASP 65  59  ?   ?   ?   A . n 
A 1 66  GLU 66  60  ?   ?   ?   A . n 
A 1 67  THR 67  61  ?   ?   ?   A . n 
A 1 68  ASP 68  62  ?   ?   ?   A . n 
A 1 69  ASP 69  63  ?   ?   ?   A . n 
A 1 70  PHE 70  64  ?   ?   ?   A . n 
A 1 71  LEU 71  65  ?   ?   ?   A . n 
A 1 72  ARG 72  66  ?   ?   ?   A . n 
A 1 73  SER 73  67  ?   ?   ?   A . n 
A 1 74  ALA 74  68  ?   ?   ?   A . n 
A 1 75  GLY 75  69  69  GLY GLY A . n 
A 1 76  CYS 76  70  70  CYS CYS A . n 
A 1 77  GLU 77  71  71  GLU GLU A . n 
A 1 78  GLU 78  72  72  GLU GLU A . n 
A 1 79  PRO 79  73  73  PRO PRO A . n 
A 1 80  ASP 80  74  74  ASP ASP A . n 
A 1 81  ALA 81  75  75  ALA ALA A . n 
A 1 82  VAL 82  76  76  VAL VAL A . n 
A 1 83  SER 83  77  77  SER SER A . n 
A 1 84  ASP 84  78  78  ASP ASP A . n 
A 1 85  ASP 85  79  79  ASP ASP A . n 
A 1 86  LEU 86  80  80  LEU LEU A . n 
A 1 87  ARG 87  81  81  ARG ARG A . n 
A 1 88  SER 88  82  82  SER SER A . n 
A 1 89  PHE 89  83  83  PHE PHE A . n 
A 1 90  ALA 90  84  84  ALA ALA A . n 
A 1 91  LEU 91  85  85  LEU LEU A . n 
A 1 92  ALA 92  86  86  ALA ALA A . n 
A 1 93  VAL 93  87  87  VAL VAL A . n 
A 1 94  LEU 94  88  ?   ?   ?   A . n 
A 1 95  HIS 95  89  ?   ?   ?   A . n 
A 1 96  GLN 96  90  ?   ?   ?   A . n 
A 1 97  ASP 97  91  ?   ?   ?   A . n 
A 1 98  ASN 98  92  ?   ?   ?   A . n 
A 1 99  PRO 99  93  ?   ?   ?   A . n 
A 1 100 LYS 100 94  ?   ?   ?   A . n 
A 1 101 LYS 101 95  ?   ?   ?   A . n 
A 1 102 ARG 102 96  ?   ?   ?   A . n 
A 1 103 ALA 103 97  ?   ?   ?   A . n 
A 1 104 PHE 104 98  ?   ?   ?   A . n 
A 1 105 LEU 105 99  ?   ?   ?   A . n 
A 1 106 GLU 106 100 ?   ?   ?   A . n 
A 1 107 SER 107 101 ?   ?   ?   A . n 
A 1 108 GLU 108 102 ?   ?   ?   A . n 
A 1 109 ASN 109 103 ?   ?   ?   A . n 
A 1 110 CYS 110 104 ?   ?   ?   A . n 
A 1 111 VAL 111 105 ?   ?   ?   A . n 
A 1 112 SER 112 106 ?   ?   ?   A . n 
A 1 113 ILE 113 107 ?   ?   ?   A . n 
A 1 114 LEU 114 108 ?   ?   ?   A . n 
A 1 115 CYS 115 109 ?   ?   ?   A . n 
A 1 116 LEU 116 110 ?   ?   ?   A . n 
A 1 117 GLU 117 111 ?   ?   ?   A . n 
A 1 118 LYS 118 112 ?   ?   ?   A . n 
A 1 119 SER 119 113 ?   ?   ?   A . n 
A 1 120 ALA 120 114 ?   ?   ?   A . n 
A 1 121 SER 121 115 ?   ?   ?   A . n 
A 1 122 GLY 122 116 ?   ?   ?   A . n 
A 1 123 THR 123 117 ?   ?   ?   A . n 
A 1 124 ARG 124 118 ?   ?   ?   A . n 
A 1 125 TYR 125 119 ?   ?   ?   A . n 
A 1 126 TYR 126 120 ?   ?   ?   A . n 
A 1 127 LYS 127 121 ?   ?   ?   A . n 
A 1 128 ARG 128 122 ?   ?   ?   A . n 
A 1 129 PRO 129 123 ?   ?   ?   A . n 
A 1 130 GLY 130 124 ?   ?   ?   A . n 
A 1 131 TYR 131 125 ?   ?   ?   A . n 
A 1 132 GLN 132 126 ?   ?   ?   A . n 
A 1 133 LEU 133 127 ?   ?   ?   A . n 
A 1 134 LEU 134 128 ?   ?   ?   A . n 
A 1 135 LYS 135 129 ?   ?   ?   A . n 
A 1 136 LYS 136 130 ?   ?   ?   A . n 
A 1 137 ALA 137 131 ?   ?   ?   A . n 
A 1 138 ILE 138 132 ?   ?   ?   A . n 
A 1 139 GLU 139 133 ?   ?   ?   A . n 
A 1 140 GLU 140 134 ?   ?   ?   A . n 
A 1 141 GLU 141 135 ?   ?   ?   A . n 
A 1 142 TRP 142 136 ?   ?   ?   A . n 
A 1 143 GLY 143 137 ?   ?   ?   A . n 
A 1 144 TRP 144 138 ?   ?   ?   A . n 
A 1 145 ASP 145 139 ?   ?   ?   A . n 
A 1 146 LYS 146 140 ?   ?   ?   A . n 
A 1 147 PHE 147 141 ?   ?   ?   A . n 
A 1 148 GLU 148 142 ?   ?   ?   A . n 
A 1 149 ALA 149 143 ?   ?   ?   A . n 
A 1 150 SER 150 144 ?   ?   ?   A . n 
A 1 151 LEU 151 145 ?   ?   ?   A . n 
A 1 152 LEU 152 146 ?   ?   ?   A . n 
A 1 153 ASP 153 147 ?   ?   ?   A . n 
A 1 154 GLU 154 148 ?   ?   ?   A . n 
A 1 155 ARG 155 149 ?   ?   ?   A . n 
A 1 156 THR 156 150 ?   ?   ?   A . n 
A 1 157 GLY 157 151 ?   ?   ?   A . n 
A 1 158 GLU 158 152 ?   ?   ?   A . n 
A 1 159 VAL 159 153 ?   ?   ?   A . n 
A 1 160 ALA 160 154 ?   ?   ?   A . n 
A 1 161 GLU 161 155 ?   ?   ?   A . n 
A 1 162 LYS 162 156 ?   ?   ?   A . n 
A 1 163 PHE 163 157 ?   ?   ?   A . n 
A 1 164 ALA 164 158 ?   ?   ?   A . n 
A 1 165 ALA 165 159 ?   ?   ?   A . n 
A 1 166 LEU 166 160 ?   ?   ?   A . n 
A 1 167 SER 167 161 ?   ?   ?   A . n 
A 1 168 MET 168 162 ?   ?   ?   A . n 
A 1 169 GLU 169 163 ?   ?   ?   A . n 
A 1 170 ASP 170 164 ?   ?   ?   A . n 
A 1 171 TRP 171 165 ?   ?   ?   A . n 
A 1 172 ARG 172 166 ?   ?   ?   A . n 
A 1 173 ARG 173 167 ?   ?   ?   A . n 
A 1 174 PHE 174 168 ?   ?   ?   A . n 
A 1 175 PHE 175 169 ?   ?   ?   A . n 
A 1 176 ALA 176 170 ?   ?   ?   A . n 
A 1 177 ALA 177 171 ?   ?   ?   A . n 
A 1 178 ARG 178 172 ?   ?   ?   A . n 
A 1 179 ASP 179 173 ?   ?   ?   A . n 
A 1 180 PRO 180 174 ?   ?   ?   A . n 
A 1 181 ASP 181 175 ?   ?   ?   A . n 
A 1 182 ASP 182 176 ?   ?   ?   A . n 
A 1 183 LEU 183 177 ?   ?   ?   A . n 
A 1 184 GLY 184 178 ?   ?   ?   A . n 
A 1 185 ARG 185 179 ?   ?   ?   A . n 
A 1 186 GLU 186 180 ?   ?   ?   A . n 
A 1 187 LEU 187 181 ?   ?   ?   A . n 
A 1 188 LEU 188 182 ?   ?   ?   A . n 
A 1 189 LYS 189 183 ?   ?   ?   A . n 
A 1 190 THR 190 184 ?   ?   ?   A . n 
A 1 191 ASP 191 185 ?   ?   ?   A . n 
A 1 192 THR 192 186 ?   ?   ?   A . n 
A 1 193 ARG 193 187 ?   ?   ?   A . n 
A 1 194 GLU 194 188 ?   ?   ?   A . n 
A 1 195 GLY 195 189 ?   ?   ?   A . n 
A 1 196 MET 196 190 ?   ?   ?   A . n 
A 1 197 ALA 197 191 191 ALA ALA A . n 
A 1 198 ALA 198 192 192 ALA ALA A . n 
A 1 199 ALA 199 193 193 ALA ALA A . n 
A 1 200 LEU 200 194 194 LEU LEU A . n 
A 1 201 ARG 201 195 195 ARG ARG A . n 
A 1 202 LEU 202 196 196 LEU LEU A . n 
A 1 203 ARG 203 197 197 ARG ARG A . n 
A 1 204 GLU 204 198 198 GLU GLU A . n 
A 1 205 ARG 205 199 199 ARG ARG A . n 
A 1 206 GLY 206 200 200 GLY GLY A . n 
A 1 207 VAL 207 201 201 VAL VAL A . n 
A 1 208 PHE 208 202 202 PHE PHE A . n 
A 1 209 PRO 209 203 203 PRO PRO A . n 
A 1 210 VAL 210 204 204 VAL VAL A . n 
A 1 211 SER 211 205 205 SER SER A . n 
A 1 212 VAL 212 206 206 VAL VAL A . n 
A 1 213 PRO 213 207 207 PRO PRO A . n 
A 1 214 GLU 214 208 208 GLU GLU A . n 
A 1 215 HIS 215 209 209 HIS HIS A . n 
A 1 216 LEU 216 210 210 LEU LEU A . n 
A 1 217 ASP 217 211 211 ASP ASP A . n 
A 1 218 LEU 218 212 212 LEU LEU A . n 
A 1 219 ASP 219 213 213 ASP ASP A . n 
A 1 220 SER 220 214 214 SER SER A . n 
A 1 221 LEU 221 215 215 LEU LEU A . n 
A 1 222 LYS 222 216 216 LYS LYS A . n 
A 1 223 ALA 223 217 217 ALA ALA A . n 
A 1 224 ALA 224 218 218 ALA ALA A . n 
A 1 225 MET 225 219 219 MET MET A . n 
A 1 226 ALA 226 220 220 ALA ALA A . n 
A 1 227 SER 227 221 221 SER SER A . n 
A 1 228 ALA 228 222 222 ALA ALA A . n 
A 1 229 ALA 229 223 223 ALA ALA A . n 
A 1 230 GLU 230 224 224 GLU GLU A . n 
A 1 231 ARG 231 225 225 ARG ARG A . n 
A 1 232 LEU 232 226 ?   ?   ?   A . n 
A 1 233 LYS 233 227 ?   ?   ?   A . n 
A 1 234 SER 234 228 ?   ?   ?   A . n 
A 1 235 TRP 235 229 ?   ?   ?   A . n 
A 1 236 LEU 236 230 ?   ?   ?   A . n 
A 1 237 ALA 237 231 ?   ?   ?   A . n 
A 1 238 CYS 238 232 ?   ?   ?   A . n 
A 1 239 ASN 239 233 ?   ?   ?   A . n 
A 1 240 GLN 240 234 ?   ?   ?   A . n 
A 1 241 ARG 241 235 ?   ?   ?   A . n 
A 1 242 ALA 242 236 ?   ?   ?   A . n 
A 1 243 VAL 243 237 ?   ?   ?   A . n 
A 1 244 ASP 244 238 ?   ?   ?   A . n 
A 1 245 GLU 245 239 ?   ?   ?   A . n 
A 1 246 LYS 246 240 ?   ?   ?   A . n 
A 1 247 SER 247 241 ?   ?   ?   A . n 
A 1 248 GLU 248 242 ?   ?   ?   A . n 
A 1 249 LEU 249 243 ?   ?   ?   A . n 
A 1 250 ARG 250 244 ?   ?   ?   A . n 
A 1 251 LYS 251 245 ?   ?   ?   A . n 
A 1 252 ARG 252 246 ?   ?   ?   A . n 
A 1 253 PHE 253 247 ?   ?   ?   A . n 
A 1 254 GLU 254 248 ?   ?   ?   A . n 
A 1 255 GLU 255 249 ?   ?   ?   A . n 
A 1 256 ALA 256 250 ?   ?   ?   A . n 
A 1 257 LEU 257 251 ?   ?   ?   A . n 
A 1 258 ASP 258 252 ?   ?   ?   A . n 
A 1 259 GLY 259 253 ?   ?   ?   A . n 
A 1 260 VAL 260 254 ?   ?   ?   A . n 
A 1 261 ASP 261 255 ?   ?   ?   A . n 
A 1 262 PRO 262 256 ?   ?   ?   A . n 
A 1 263 GLU 263 257 ?   ?   ?   A . n 
A 1 264 LYS 264 258 ?   ?   ?   A . n 
A 1 265 TYR 265 259 ?   ?   ?   A . n 
A 1 266 ALA 266 260 ?   ?   ?   A . n 
A 1 267 LEU 267 261 ?   ?   ?   A . n 
A 1 268 PHE 268 262 ?   ?   ?   A . n 
A 1 269 GLU 269 263 ?   ?   ?   A . n 
A 1 270 LYS 270 264 ?   ?   ?   A . n 
A 1 271 PHE 271 265 ?   ?   ?   A . n 
A 1 272 ALA 272 266 ?   ?   ?   A . n 
A 1 273 ALA 273 267 ?   ?   ?   A . n 
A 1 274 GLU 274 268 ?   ?   ?   A . n 
A 1 275 LEU 275 269 ?   ?   ?   A . n 
A 1 276 GLN 276 270 ?   ?   ?   A . n 
A 1 277 GLN 277 271 ?   ?   ?   A . n 
A 1 278 ALA 278 272 ?   ?   ?   A . n 
A 1 279 ASP 279 273 ?   ?   ?   A . n 
A 1 280 TYR 280 274 ?   ?   ?   A . n 
A 1 281 ASN 281 275 ?   ?   ?   A . n 
A 1 282 VAL 282 276 ?   ?   ?   A . n 
A 1 283 THR 283 277 ?   ?   ?   A . n 
A 1 284 LYS 284 278 ?   ?   ?   A . n 
A 1 285 LYS 285 279 ?   ?   ?   A . n 
A 1 286 LEU 286 280 ?   ?   ?   A . n 
A 1 287 VAL 287 281 ?   ?   ?   A . n 
A 1 288 LEU 288 282 ?   ?   ?   A . n 
A 1 289 ALA 289 283 ?   ?   ?   A . n 
A 1 290 VAL 290 284 ?   ?   ?   A . n 
A 1 291 SER 291 285 ?   ?   ?   A . n 
A 1 292 ALA 292 286 ?   ?   ?   A . n 
A 1 293 LYS 293 287 ?   ?   ?   A . n 
A 1 294 PHE 294 288 ?   ?   ?   A . n 
A 1 295 PRO 295 289 ?   ?   ?   A . n 
A 1 296 ALA 296 290 ?   ?   ?   A . n 
A 1 297 THR 297 291 ?   ?   ?   A . n 
A 1 298 GLU 298 292 ?   ?   ?   A . n 
A 1 299 PRO 299 293 ?   ?   ?   A . n 
A 1 300 SER 300 294 ?   ?   ?   A . n 
A 1 301 GLU 301 295 ?   ?   ?   A . n 
A 1 302 PHE 302 296 ?   ?   ?   A . n 
A 1 303 LYS 303 297 ?   ?   ?   A . n 
A 1 304 ARG 304 298 ?   ?   ?   A . n 
A 1 305 GLY 305 299 ?   ?   ?   A . n 
A 1 306 VAL 306 300 ?   ?   ?   A . n 
A 1 307 GLU 307 301 ?   ?   ?   A . n 
A 1 308 ILE 308 302 ?   ?   ?   A . n 
A 1 309 LEU 309 303 ?   ?   ?   A . n 
A 1 310 LYS 310 304 ?   ?   ?   A . n 
A 1 311 GLU 311 305 ?   ?   ?   A . n 
A 1 312 ASP 312 306 ?   ?   ?   A . n 
A 1 313 GLY 313 307 ?   ?   ?   A . n 
A 1 314 TYR 314 308 ?   ?   ?   A . n 
A 1 315 LYS 315 309 ?   ?   ?   A . n 
A 1 316 PRO 316 310 ?   ?   ?   A . n 
A 1 317 LEU 317 311 ?   ?   ?   A . n 
A 1 318 TRP 318 312 ?   ?   ?   A . n 
A 1 319 GLU 319 313 ?   ?   ?   A . n 
A 1 320 ASP 320 314 ?   ?   ?   A . n 
A 1 321 PHE 321 315 ?   ?   ?   A . n 
A 1 322 ARG 322 316 ?   ?   ?   A . n 
A 1 323 GLU 323 317 ?   ?   ?   A . n 
A 1 324 LEU 324 318 ?   ?   ?   A . n 
A 1 325 GLY 325 319 ?   ?   ?   A . n 
A 1 326 PHE 326 320 ?   ?   ?   A . n 
A 1 327 VAL 327 321 ?   ?   ?   A . n 
A 1 328 TYR 328 322 ?   ?   ?   A . n 
A 1 329 LEU 329 323 ?   ?   ?   A . n 
A 1 330 ALA 330 324 ?   ?   ?   A . n 
A 1 331 GLU 331 325 ?   ?   ?   A . n 
A 1 332 ARG 332 326 ?   ?   ?   A . n 
A 1 333 LYS 333 327 ?   ?   ?   A . n 
A 1 334 TRP 334 328 ?   ?   ?   A . n 
A 1 335 GLU 335 329 ?   ?   ?   A . n 
A 1 336 ARG 336 330 ?   ?   ?   A . n 
A 1 337 ARG 337 331 ?   ?   ?   A . n 
A 1 338 ARG 338 332 ?   ?   ?   A . n 
A 1 339 GLY 339 333 ?   ?   ?   A . n 
A 1 340 GLY 340 334 ?   ?   ?   A . n 
A 1 341 ALA 341 335 ?   ?   ?   A . n 
A 1 342 ALA 342 336 ?   ?   ?   A . n 
A 1 343 VAL 343 337 ?   ?   ?   A . n 
A 1 344 THR 344 338 ?   ?   ?   A . n 
A 1 345 LEU 345 339 ?   ?   ?   A . n 
A 1 346 CYS 346 340 ?   ?   ?   A . n 
A 1 347 ASP 347 341 ?   ?   ?   A . n 
A 1 348 ALA 348 342 ?   ?   ?   A . n 
A 1 349 ASP 349 343 ?   ?   ?   A . n 
A 1 350 ASP 350 344 ?   ?   ?   A . n 
A 1 351 SER 351 345 ?   ?   ?   A . n 
A 1 352 PRO 352 346 ?   ?   ?   A . n 
A 1 353 ILE 353 347 ?   ?   ?   A . n 
A 1 354 LYS 354 348 348 LYS LYS A . n 
A 1 355 VAL 355 349 349 VAL VAL A . n 
A 1 356 ARG 356 350 350 ARG ARG A . n 
A 1 357 PHE 357 351 351 PHE PHE A . n 
A 1 358 GLY 358 352 352 GLY GLY A . n 
A 1 359 LEU 359 353 353 LEU LEU A . n 
A 1 360 THR 360 354 354 THR THR A . n 
A 1 361 GLY 361 355 ?   ?   ?   A . n 
A 1 362 ARG 362 356 ?   ?   ?   A . n 
A 1 363 GLY 363 357 357 GLY GLY A . n 
A 1 364 ARG 364 358 358 ARG ARG A . n 
A 1 365 LYS 365 359 359 LYS LYS A . n 
A 1 366 PHE 366 360 360 PHE PHE A . n 
A 1 367 VAL 367 361 361 VAL VAL A . n 
A 1 368 LEU 368 362 362 LEU LEU A . n 
A 1 369 SER 369 363 363 SER SER A . n 
A 1 370 ALA 370 364 364 ALA ALA A . n 
A 1 371 ALA 371 365 365 ALA ALA A . n 
A 1 372 GLY 372 366 366 GLY GLY A . n 
A 1 373 SER 373 367 367 SER SER A . n 
A 1 374 ARG 374 368 368 ARG ARG A . n 
A 1 375 PHE 375 369 369 PHE PHE A . n 
A 1 376 LEU 376 370 370 LEU LEU A . n 
A 1 377 ILE 377 371 371 ILE ILE A . n 
A 1 378 THR 378 372 372 THR THR A . n 
A 1 379 VAL 379 373 373 VAL VAL A . n 
A 1 380 LYS 380 374 374 LYS LYS A . n 
A 1 381 LEU 381 375 375 LEU LEU A . n 
A 1 382 PRO 382 376 376 PRO PRO A . n 
A 1 383 CYS 383 377 377 CYS CYS A . n 
A 1 384 GLY 384 378 378 GLY GLY A . n 
A 1 385 ASP 385 379 379 ASP ASP A . n 
A 1 386 VAL 386 380 380 VAL VAL A . n 
A 1 387 GLY 387 381 381 GLY GLY A . n 
A 1 388 LEU 388 382 382 LEU LEU A . n 
A 1 389 THR 389 383 383 THR THR A . n 
A 1 390 ALA 390 384 384 ALA ALA A . n 
A 1 391 VAL 391 385 385 VAL VAL A . n 
A 1 392 PRO 392 386 386 PRO PRO A . n 
A 1 393 SER 393 387 387 SER SER A . n 
A 1 394 ARG 394 388 388 ARG ARG A . n 
A 1 395 TYR 395 389 389 TYR TYR A . n 
A 1 396 PHE 396 390 390 PHE PHE A . n 
A 1 397 TRP 397 391 391 TRP TRP A . n 
A 1 398 ASN 398 392 392 ASN ASN A . n 
A 1 399 PRO 399 393 393 PRO PRO A . n 
A 1 400 SER 400 394 394 SER SER A . n 
A 1 401 VAL 401 395 395 VAL VAL A . n 
A 1 402 GLY 402 396 396 GLY GLY A . n 
A 1 403 ARG 403 397 397 ARG ARG A . n 
A 1 404 THR 404 398 398 THR THR A . n 
A 1 405 THR 405 399 399 THR THR A . n 
A 1 406 SER 406 400 400 SER SER A . n 
A 1 407 ASN 407 401 401 ASN ASN A . n 
A 1 408 SER 408 402 402 SER SER A . n 
A 1 409 PHE 409 403 403 PHE PHE A . n 
A 1 410 ARG 410 404 404 ARG ARG A . n 
A 1 411 ILE 411 405 405 ILE ILE A . n 
A 1 412 GLU 412 406 406 GLU GLU A . n 
A 1 413 PHE 413 407 407 PHE PHE A . n 
A 1 414 THR 414 408 408 THR THR A . n 
A 1 415 LYS 415 409 409 LYS LYS A . n 
A 1 416 ARG 416 410 ?   ?   ?   A . n 
A 1 417 THR 417 411 ?   ?   ?   A . n 
A 1 418 THR 418 412 ?   ?   ?   A . n 
A 1 419 GLU 419 413 413 GLU GLU A . n 
A 1 420 ASN 420 414 414 ASN ASN A . n 
A 1 421 ARG 421 415 415 ARG ARG A . n 
A 1 422 ARG 422 416 416 ARG ARG A . n 
A 1 423 TYR 423 417 417 TYR TYR A . n 
A 1 424 VAL 424 418 418 VAL VAL A . n 
A 1 425 GLY 425 419 419 GLY GLY A . n 
A 1 426 GLU 426 420 420 GLU GLU A . n 
A 1 427 VAL 427 421 421 VAL VAL A . n 
A 1 428 LYS 428 422 422 LYS LYS A . n 
A 1 429 GLU 429 423 423 GLU GLU A . n 
A 1 430 ILE 430 424 424 ILE ILE A . n 
A 1 431 GLY 431 425 425 GLY GLY A . n 
A 1 432 LEU 432 426 426 LEU LEU A . n 
A 1 433 VAL 433 427 427 VAL VAL A . n 
A 1 434 ARG 434 428 428 ARG ARG A . n 
A 1 435 GLN 435 429 429 GLN GLN A . n 
A 1 436 ARG 436 430 430 ARG ARG A . n 
A 1 437 GLY 437 431 431 GLY GLY A . n 
A 1 438 ARG 438 432 432 ARG ARG A . n 
A 1 439 TYR 439 433 433 TYR TYR A . n 
A 1 440 TYR 440 434 434 TYR TYR A . n 
A 1 441 PHE 441 435 435 PHE PHE A . n 
A 1 442 PHE 442 436 436 PHE PHE A . n 
A 1 443 ILE 443 437 437 ILE ILE A . n 
A 1 444 ASP 444 438 438 ASP ASP A . n 
A 1 445 TYR 445 439 439 TYR TYR A . n 
A 1 446 ASN 446 440 440 ASN ASN A . n 
A 1 447 PHE 447 441 441 PHE PHE A . n 
A 1 448 ASP 448 442 442 ASP ASP A . n 
A 1 449 PRO 449 443 443 PRO PRO A . n 
A 1 450 GLU 450 444 444 GLU GLU A . n 
A 1 451 GLU 451 445 445 GLU GLU A . n 
A 1 452 VAL 452 446 446 VAL VAL A . n 
A 1 453 SER 453 447 447 SER SER A . n 
A 1 454 ASP 454 448 448 ASP ASP A . n 
A 1 455 GLU 455 449 449 GLU GLU A . n 
A 1 456 THR 456 450 450 THR THR A . n 
A 1 457 LYS 457 451 451 LYS LYS A . n 
A 1 458 VAL 458 452 452 VAL VAL A . n 
A 1 459 GLY 459 453 453 GLY GLY A . n 
A 1 460 ARG 460 454 454 ARG ARG A . n 
A 1 461 ALA 461 455 455 ALA ALA A . n 
A 1 462 PHE 462 456 456 PHE PHE A . n 
A 1 463 PHE 463 457 457 PHE PHE A . n 
A 1 464 ARG 464 458 458 ARG ARG A . n 
A 1 465 ALA 465 459 459 ALA ALA A . n 
A 1 466 PRO 466 460 460 PRO PRO A . n 
A 1 467 LEU 467 461 461 LEU LEU A . n 
A 1 468 ASN 468 462 462 ASN ASN A . n 
A 1 469 GLU 469 463 463 GLU GLU A . n 
A 1 470 SER 470 464 464 SER SER A . n 
A 1 471 ARG 471 465 465 ARG ARG A . n 
A 1 472 PRO 472 466 466 PRO PRO A . n 
A 1 473 LYS 473 467 467 LYS LYS A . n 
A 1 474 PRO 474 468 468 PRO PRO A . n 
A 1 475 LYS 475 469 469 LYS LYS A . n 
A 1 476 ASP 476 470 470 ASP ASP A . n 
A 1 477 LYS 477 471 471 LYS LYS A . n 
A 1 478 LEU 478 472 472 LEU LEU A . n 
A 1 479 THR 479 473 473 THR THR A . n 
A 1 480 VAL 480 474 474 VAL VAL A . n 
A 1 481 MET 481 475 475 MET MET A . n 
A 1 482 GLY 482 476 476 GLY GLY A . n 
A 1 483 ILE 483 477 477 ILE ILE A . n 
A 1 484 ASP 484 478 478 ASP ASP A . n 
A 1 485 LEU 485 479 479 LEU LEU A . n 
A 1 486 GLY 486 480 480 GLY GLY A . n 
A 1 487 ILE 487 481 481 ILE ILE A . n 
A 1 488 ASN 488 482 482 ASN ASN A . n 
A 1 489 PRO 489 483 483 PRO PRO A . n 
A 1 490 ALA 490 484 484 ALA ALA A . n 
A 1 491 PHE 491 485 485 PHE PHE A . n 
A 1 492 ALA 492 486 486 ALA ALA A . n 
A 1 493 PHE 493 487 487 PHE PHE A . n 
A 1 494 ALA 494 488 488 ALA ALA A . n 
A 1 495 VAL 495 489 489 VAL VAL A . n 
A 1 496 CYS 496 490 490 CYS CYS A . n 
A 1 497 THR 497 491 491 THR THR A . n 
A 1 498 LEU 498 492 492 LEU LEU A . n 
A 1 499 GLY 499 493 493 GLY GLY A . n 
A 1 500 GLU 500 494 494 GLU GLU A . n 
A 1 501 CYS 501 495 495 CYS CYS A . n 
A 1 502 GLN 502 496 496 GLN GLN A . n 
A 1 503 ASP 503 497 497 ASP ASP A . n 
A 1 504 GLY 504 498 498 GLY GLY A . n 
A 1 505 ILE 505 499 499 ILE ILE A . n 
A 1 506 ARG 506 500 500 ARG ARG A . n 
A 1 507 SER 507 501 501 SER SER A . n 
A 1 508 PRO 508 502 502 PRO PRO A . n 
A 1 509 VAL 509 503 503 VAL VAL A . n 
A 1 510 ALA 510 504 504 ALA ALA A . n 
A 1 511 LYS 511 505 505 LYS LYS A . n 
A 1 512 MET 512 506 506 MET MET A . n 
A 1 513 GLU 513 507 507 GLU GLU A . n 
A 1 514 ASP 514 508 508 ASP ASP A . n 
A 1 515 VAL 515 509 509 VAL VAL A . n 
A 1 516 SER 516 510 510 SER SER A . n 
A 1 517 PHE 517 511 511 PHE PHE A . n 
A 1 518 ASP 518 512 512 ASP ASP A . n 
A 1 519 SER 519 513 513 SER SER A . n 
A 1 520 THR 520 514 514 THR THR A . n 
A 1 521 GLY 521 515 515 GLY GLY A . n 
A 1 522 LEU 522 516 516 LEU LEU A . n 
A 1 523 ARG 523 517 517 ARG ARG A . n 
A 1 524 GLY 524 518 518 GLY GLY A . n 
A 1 525 GLY 525 519 519 GLY GLY A . n 
A 1 526 ILE 526 520 520 ILE ILE A . n 
A 1 527 GLY 527 521 521 GLY GLY A . n 
A 1 528 SER 528 522 522 SER SER A . n 
A 1 529 GLN 529 523 523 GLN GLN A . n 
A 1 530 LYS 530 524 524 LYS LYS A . n 
A 1 531 LEU 531 525 525 LEU LEU A . n 
A 1 532 HIS 532 526 526 HIS HIS A . n 
A 1 533 ARG 533 527 527 ARG ARG A . n 
A 1 534 GLU 534 528 528 GLU GLU A . n 
A 1 535 MET 535 529 529 MET MET A . n 
A 1 536 HIS 536 530 530 HIS HIS A . n 
A 1 537 ASN 537 531 531 ASN ASN A . n 
A 1 538 LEU 538 532 532 LEU LEU A . n 
A 1 539 SER 539 533 533 SER SER A . n 
A 1 540 ASP 540 534 534 ASP ASP A . n 
A 1 541 ARG 541 535 535 ARG ARG A . n 
A 1 542 CYS 542 536 536 CYS CYS A . n 
A 1 543 PHE 543 537 537 PHE PHE A . n 
A 1 544 TYR 544 538 538 TYR TYR A . n 
A 1 545 GLY 545 539 539 GLY GLY A . n 
A 1 546 ALA 546 540 540 ALA ALA A . n 
A 1 547 ARG 547 541 541 ARG ARG A . n 
A 1 548 TYR 548 542 542 TYR TYR A . n 
A 1 549 ILE 549 543 543 ILE ILE A . n 
A 1 550 ARG 550 544 544 ARG ARG A . n 
A 1 551 LEU 551 545 545 LEU LEU A . n 
A 1 552 SER 552 546 546 SER SER A . n 
A 1 553 LYS 553 547 547 LYS LYS A . n 
A 1 554 LYS 554 548 548 LYS LYS A . n 
A 1 555 LEU 555 549 549 LEU LEU A . n 
A 1 556 ARG 556 550 550 ARG ARG A . n 
A 1 557 ASP 557 551 551 ASP ASP A . n 
A 1 558 ARG 558 552 552 ARG ARG A . n 
A 1 559 GLY 559 553 553 GLY GLY A . n 
A 1 560 ALA 560 554 554 ALA ALA A . n 
A 1 561 LEU 561 555 555 LEU LEU A . n 
A 1 562 ASN 562 556 556 ASN ASN A . n 
A 1 563 ASP 563 557 557 ASP ASP A . n 
A 1 564 ILE 564 558 558 ILE ILE A . n 
A 1 565 GLU 565 559 559 GLU GLU A . n 
A 1 566 ALA 566 560 560 ALA ALA A . n 
A 1 567 ARG 567 561 561 ARG ARG A . n 
A 1 568 LEU 568 562 562 LEU LEU A . n 
A 1 569 LEU 569 563 563 LEU LEU A . n 
A 1 570 GLU 570 564 564 GLU GLU A . n 
A 1 571 GLU 571 565 565 GLU GLU A . n 
A 1 572 LYS 572 566 566 LYS LYS A . n 
A 1 573 TYR 573 567 567 TYR TYR A . n 
A 1 574 ILE 574 568 568 ILE ILE A . n 
A 1 575 PRO 575 569 569 PRO PRO A . n 
A 1 576 GLY 576 570 570 GLY GLY A . n 
A 1 577 PHE 577 571 571 PHE PHE A . n 
A 1 578 ARG 578 572 572 ARG ARG A . n 
A 1 579 ILE 579 573 573 ILE ILE A . n 
A 1 580 VAL 580 574 574 VAL VAL A . n 
A 1 581 HIS 581 575 575 HIS HIS A . n 
A 1 582 ILE 582 576 576 ILE ILE A . n 
A 1 583 GLU 583 577 577 GLU GLU A . n 
A 1 584 ASP 584 578 578 ASP ASP A . n 
A 1 585 ALA 585 579 579 ALA ALA A . n 
A 1 586 ASP 586 580 580 ASP ASP A . n 
A 1 587 GLU 587 581 581 GLU GLU A . n 
A 1 588 ARG 588 582 582 ARG ARG A . n 
A 1 589 ARG 589 583 583 ARG ARG A . n 
A 1 590 ARG 590 584 584 ARG ARG A . n 
A 1 591 THR 591 585 585 THR THR A . n 
A 1 592 VAL 592 586 586 VAL VAL A . n 
A 1 593 GLY 593 587 587 GLY GLY A . n 
A 1 594 ARG 594 588 588 ARG ARG A . n 
A 1 595 THR 595 589 589 THR THR A . n 
A 1 596 VAL 596 590 590 VAL VAL A . n 
A 1 597 LYS 597 591 591 LYS LYS A . n 
A 1 598 GLU 598 592 592 GLU GLU A . n 
A 1 599 ILE 599 593 593 ILE ILE A . n 
A 1 600 LYS 600 594 594 LYS LYS A . n 
A 1 601 GLN 601 595 595 GLN GLN A . n 
A 1 602 GLU 602 596 596 GLU GLU A . n 
A 1 603 TYR 603 597 597 TYR TYR A . n 
A 1 604 LYS 604 598 598 LYS LYS A . n 
A 1 605 ARG 605 599 599 ARG ARG A . n 
A 1 606 ILE 606 600 600 ILE ILE A . n 
A 1 607 ARG 607 601 601 ARG ARG A . n 
A 1 608 HIS 608 602 602 HIS HIS A . n 
A 1 609 GLN 609 603 603 GLN GLN A . n 
A 1 610 PHE 610 604 604 PHE PHE A . n 
A 1 611 TYR 611 605 605 TYR TYR A . n 
A 1 612 LEU 612 606 606 LEU LEU A . n 
A 1 613 ARG 613 607 607 ARG ARG A . n 
A 1 614 TYR 614 608 608 TYR TYR A . n 
A 1 615 HIS 615 609 609 HIS HIS A . n 
A 1 616 THR 616 610 610 THR THR A . n 
A 1 617 SER 617 611 611 SER SER A . n 
A 1 618 LYS 618 612 612 LYS LYS A . n 
A 1 619 ARG 619 613 613 ARG ARG A . n 
A 1 620 ASP 620 614 614 ASP ASP A . n 
A 1 621 ARG 621 615 615 ARG ARG A . n 
A 1 622 THR 622 616 616 THR THR A . n 
A 1 623 GLU 623 617 617 GLU GLU A . n 
A 1 624 LEU 624 618 618 LEU LEU A . n 
A 1 625 ILE 625 619 619 ILE ILE A . n 
A 1 626 SER 626 620 620 SER SER A . n 
A 1 627 ALA 627 621 621 ALA ALA A . n 
A 1 628 GLU 628 622 622 GLU GLU A . n 
A 1 629 TYR 629 623 623 TYR TYR A . n 
A 1 630 PHE 630 624 624 PHE PHE A . n 
A 1 631 ARG 631 625 625 ARG ARG A . n 
A 1 632 MET 632 626 626 MET MET A . n 
A 1 633 LEU 633 627 627 LEU LEU A . n 
A 1 634 PHE 634 628 628 PHE PHE A . n 
A 1 635 LEU 635 629 629 LEU LEU A . n 
A 1 636 VAL 636 630 630 VAL VAL A . n 
A 1 637 LYS 637 631 631 LYS LYS A . n 
A 1 638 ASN 638 632 632 ASN ASN A . n 
A 1 639 LEU 639 633 633 LEU LEU A . n 
A 1 640 ARG 640 634 634 ARG ARG A . n 
A 1 641 ASN 641 635 635 ASN ASN A . n 
A 1 642 LEU 642 636 636 LEU LEU A . n 
A 1 643 LEU 643 637 637 LEU LEU A . n 
A 1 644 LYS 644 638 638 LYS LYS A . n 
A 1 645 SER 645 639 639 SER SER A . n 
A 1 646 TRP 646 640 640 TRP TRP A . n 
A 1 647 ASN 647 641 641 ASN ASN A . n 
A 1 648 ARG 648 642 642 ARG ARG A . n 
A 1 649 TYR 649 643 643 TYR TYR A . n 
A 1 650 HIS 650 644 644 HIS HIS A . n 
A 1 651 TRP 651 645 645 TRP TRP A . n 
A 1 652 THR 652 646 646 THR THR A . n 
A 1 653 THR 653 647 647 THR THR A . n 
A 1 654 GLY 654 648 648 GLY GLY A . n 
A 1 655 ASP 655 649 649 ASP ASP A . n 
A 1 656 ARG 656 650 650 ARG ARG A . n 
A 1 657 GLU 657 651 651 GLU GLU A . n 
A 1 658 ARG 658 652 652 ARG ARG A . n 
A 1 659 ARG 659 653 653 ARG ARG A . n 
A 1 660 GLY 660 654 654 GLY GLY A . n 
A 1 661 GLY 661 655 655 GLY GLY A . n 
A 1 662 ASN 662 656 656 ASN ASN A . n 
A 1 663 PRO 663 657 657 PRO PRO A . n 
A 1 664 ASP 664 658 658 ASP ASP A . n 
A 1 665 GLU 665 659 659 GLU GLU A . n 
A 1 666 LEU 666 660 660 LEU LEU A . n 
A 1 667 LYS 667 661 661 LYS LYS A . n 
A 1 668 SER 668 662 662 SER SER A . n 
A 1 669 TYR 669 663 663 TYR TYR A . n 
A 1 670 VAL 670 664 664 VAL VAL A . n 
A 1 671 ARG 671 665 665 ARG ARG A . n 
A 1 672 TYR 672 666 666 TYR TYR A . n 
A 1 673 TYR 673 667 667 TYR TYR A . n 
A 1 674 ASN 674 668 668 ASN ASN A . n 
A 1 675 ASN 675 669 669 ASN ASN A . n 
A 1 676 LEU 676 670 670 LEU LEU A . n 
A 1 677 ARG 677 671 671 ARG ARG A . n 
A 1 678 MET 678 672 672 MET MET A . n 
A 1 679 ASP 679 673 673 ASP ASP A . n 
A 1 680 THR 680 674 674 THR THR A . n 
A 1 681 LEU 681 675 675 LEU LEU A . n 
A 1 682 LYS 682 676 676 LYS LYS A . n 
A 1 683 LYS 683 677 677 LYS LYS A . n 
A 1 684 LEU 684 678 678 LEU LEU A . n 
A 1 685 THR 685 679 679 THR THR A . n 
A 1 686 CYS 686 680 680 CYS CYS A . n 
A 1 687 ALA 687 681 681 ALA ALA A . n 
A 1 688 ILE 688 682 682 ILE ILE A . n 
A 1 689 VAL 689 683 683 VAL VAL A . n 
A 1 690 ARG 690 684 684 ARG ARG A . n 
A 1 691 THR 691 685 685 THR THR A . n 
A 1 692 ALA 692 686 686 ALA ALA A . n 
A 1 693 LYS 693 687 687 LYS LYS A . n 
A 1 694 GLU 694 688 688 GLU GLU A . n 
A 1 695 HIS 695 689 689 HIS HIS A . n 
A 1 696 GLY 696 690 690 GLY GLY A . n 
A 1 697 ALA 697 691 691 ALA ALA A . n 
A 1 698 THR 698 692 692 THR THR A . n 
A 1 699 LEU 699 693 693 LEU LEU A . n 
A 1 700 VAL 700 694 694 VAL VAL A . n 
A 1 701 ALA 701 695 695 ALA ALA A . n 
A 1 702 MET 702 696 696 MET MET A . n 
A 1 703 GLU 703 697 697 GLU GLU A . n 
A 1 704 ASN 704 698 698 ASN ASN A . n 
A 1 705 ILE 705 699 699 ILE ILE A . n 
A 1 706 GLN 706 700 700 GLN GLN A . n 
A 1 707 ARG 707 701 701 ARG ARG A . n 
A 1 708 VAL 708 702 ?   ?   ?   A . n 
A 1 709 ASP 709 703 ?   ?   ?   A . n 
A 1 710 ARG 710 704 ?   ?   ?   A . n 
A 1 711 ASP 711 705 ?   ?   ?   A . n 
A 1 712 ASP 712 706 ?   ?   ?   A . n 
A 1 713 GLU 713 707 ?   ?   ?   A . n 
A 1 714 VAL 714 708 ?   ?   ?   A . n 
A 1 715 LYS 715 709 ?   ?   ?   A . n 
A 1 716 ARG 716 710 ?   ?   ?   A . n 
A 1 717 ARG 717 711 ?   ?   ?   A . n 
A 1 718 LYS 718 712 ?   ?   ?   A . n 
A 1 719 GLU 719 713 713 GLU GLU A . n 
A 1 720 ASN 720 714 714 ASN ASN A . n 
A 1 721 SER 721 715 715 SER SER A . n 
A 1 722 LEU 722 716 716 LEU LEU A . n 
A 1 723 LEU 723 717 717 LEU LEU A . n 
A 1 724 SER 724 718 718 SER SER A . n 
A 1 725 LEU 725 719 719 LEU LEU A . n 
A 1 726 TRP 726 720 720 TRP TRP A . n 
A 1 727 ALA 727 721 721 ALA ALA A . n 
A 1 728 PRO 728 722 722 PRO PRO A . n 
A 1 729 GLY 729 723 723 GLY GLY A . n 
A 1 730 MET 730 724 724 MET MET A . n 
A 1 731 VAL 731 725 725 VAL VAL A . n 
A 1 732 LEU 732 726 726 LEU LEU A . n 
A 1 733 GLU 733 727 727 GLU GLU A . n 
A 1 734 ARG 734 728 728 ARG ARG A . n 
A 1 735 VAL 735 729 729 VAL VAL A . n 
A 1 736 GLU 736 730 730 GLU GLU A . n 
A 1 737 GLN 737 731 731 GLN GLN A . n 
A 1 738 GLU 738 732 732 GLU GLU A . n 
A 1 739 LEU 739 733 733 LEU LEU A . n 
A 1 740 LYS 740 734 734 LYS LYS A . n 
A 1 741 ASN 741 735 735 ASN ASN A . n 
A 1 742 GLU 742 736 736 GLU GLU A . n 
A 1 743 GLY 743 737 737 GLY GLY A . n 
A 1 744 ILE 744 738 738 ILE ILE A . n 
A 1 745 LEU 745 739 739 LEU LEU A . n 
A 1 746 ALA 746 740 740 ALA ALA A . n 
A 1 747 TRP 747 741 741 TRP TRP A . n 
A 1 748 GLU 748 742 742 GLU GLU A . n 
A 1 749 VAL 749 743 743 VAL VAL A . n 
A 1 750 ASP 750 744 744 ASP ASP A . n 
A 1 751 PRO 751 745 745 PRO PRO A . n 
A 1 752 ARG 752 746 746 ARG ARG A . n 
A 1 753 HIS 753 747 747 HIS HIS A . n 
A 1 754 THR 754 748 748 THR THR A . n 
A 1 755 SER 755 749 749 SER SER A . n 
A 1 756 GLN 756 750 750 GLN GLN A . n 
A 1 757 THR 757 751 751 THR THR A . n 
A 1 758 SER 758 752 752 SER SER A . n 
A 1 759 CYS 759 753 753 CYS CYS A . n 
A 1 760 ILE 760 754 754 ILE ILE A . n 
A 1 761 THR 761 755 755 THR THR A . n 
A 1 762 ASP 762 756 756 ASP ASP A . n 
A 1 763 GLU 763 757 757 GLU GLU A . n 
A 1 764 PHE 764 758 758 PHE PHE A . n 
A 1 765 GLY 765 759 759 GLY GLY A . n 
A 1 766 TYR 766 760 760 TYR TYR A . n 
A 1 767 ARG 767 761 761 ARG ARG A . n 
A 1 768 SER 768 762 762 SER SER A . n 
A 1 769 LEU 769 763 763 LEU LEU A . n 
A 1 770 VAL 770 764 764 VAL VAL A . n 
A 1 771 ALA 771 765 765 ALA ALA A . n 
A 1 772 LYS 772 766 766 LYS LYS A . n 
A 1 773 ASP 773 767 767 ASP ASP A . n 
A 1 774 THR 774 768 768 THR THR A . n 
A 1 775 PHE 775 769 769 PHE PHE A . n 
A 1 776 TYR 776 770 770 TYR TYR A . n 
A 1 777 PHE 777 771 771 PHE PHE A . n 
A 1 778 GLU 778 772 772 GLU GLU A . n 
A 1 779 GLN 779 773 773 GLN GLN A . n 
A 1 780 ASP 780 774 774 ASP ASP A . n 
A 1 781 ARG 781 775 775 ARG ARG A . n 
A 1 782 LYS 782 776 776 LYS LYS A . n 
A 1 783 ILE 783 777 777 ILE ILE A . n 
A 1 784 HIS 784 778 778 HIS HIS A . n 
A 1 785 ARG 785 779 779 ARG ARG A . n 
A 1 786 ILE 786 780 780 ILE ILE A . n 
A 1 787 ASP 787 781 781 ASP ASP A . n 
A 1 788 ALA 788 782 782 ALA ALA A . n 
A 1 789 ASP 789 783 783 ASP ASP A . n 
A 1 790 VAL 790 784 784 VAL VAL A . n 
A 1 791 ASN 791 785 785 ASN ASN A . n 
A 1 792 ALA 792 786 786 ALA ALA A . n 
A 1 793 ALA 793 787 787 ALA ALA A . n 
A 1 794 ILE 794 788 788 ILE ILE A . n 
A 1 795 ASN 795 789 789 ASN ASN A . n 
A 1 796 ILE 796 790 790 ILE ILE A . n 
A 1 797 ALA 797 791 791 ALA ALA A . n 
A 1 798 ARG 798 792 792 ARG ARG A . n 
A 1 799 ARG 799 793 793 ARG ARG A . n 
A 1 800 PHE 800 794 794 PHE PHE A . n 
A 1 801 LEU 801 795 795 LEU LEU A . n 
A 1 802 THR 802 796 796 THR THR A . n 
A 1 803 ARG 803 797 797 ARG ARG A . n 
A 1 804 TYR 804 798 798 TYR TYR A . n 
A 1 805 ARG 805 799 799 ARG ARG A . n 
A 1 806 SER 806 800 800 SER SER A . n 
A 1 807 LEU 807 801 801 LEU LEU A . n 
A 1 808 THR 808 802 802 THR THR A . n 
A 1 809 GLN 809 803 803 GLN GLN A . n 
A 1 810 LEU 810 804 804 LEU LEU A . n 
A 1 811 TRP 811 805 805 TRP TRP A . n 
A 1 812 ALA 812 806 806 ALA ALA A . n 
A 1 813 SER 813 807 807 SER SER A . n 
A 1 814 LEU 814 808 808 LEU LEU A . n 
A 1 815 LEU 815 809 809 LEU LEU A . n 
A 1 816 ASP 816 810 810 ASP ASP A . n 
A 1 817 ASP 817 811 811 ASP ASP A . n 
A 1 818 GLY 818 812 812 GLY GLY A . n 
A 1 819 ARG 819 813 813 ARG ARG A . n 
A 1 820 TYR 820 814 814 TYR TYR A . n 
A 1 821 LEU 821 815 815 LEU LEU A . n 
A 1 822 VAL 822 816 816 VAL VAL A . n 
A 1 823 ASN 823 817 817 ASN ASN A . n 
A 1 824 VAL 824 818 818 VAL VAL A . n 
A 1 825 THR 825 819 819 THR THR A . n 
A 1 826 ARG 826 820 820 ARG ARG A . n 
A 1 827 GLN 827 821 821 GLN GLN A . n 
A 1 828 HIS 828 822 822 HIS HIS A . n 
A 1 829 GLU 829 823 823 GLU GLU A . n 
A 1 830 ARG 830 824 824 ARG ARG A . n 
A 1 831 ALA 831 825 825 ALA ALA A . n 
A 1 832 TYR 832 826 826 TYR TYR A . n 
A 1 833 LEU 833 827 827 LEU LEU A . n 
A 1 834 GLU 834 828 828 GLU GLU A . n 
A 1 835 LEU 835 829 829 LEU LEU A . n 
A 1 836 GLN 836 830 830 GLN GLN A . n 
A 1 837 THR 837 831 831 THR THR A . n 
A 1 838 GLY 838 832 832 GLY GLY A . n 
A 1 839 ALA 839 833 833 ALA ALA A . n 
A 1 840 PRO 840 834 834 PRO PRO A . n 
A 1 841 ALA 841 835 835 ALA ALA A . n 
A 1 842 ALA 842 836 836 ALA ALA A . n 
A 1 843 THR 843 837 837 THR THR A . n 
A 1 844 LEU 844 838 838 LEU LEU A . n 
A 1 845 ASN 845 839 839 ASN ASN A . n 
A 1 846 PRO 846 840 840 PRO PRO A . n 
A 1 847 THR 847 841 841 THR THR A . n 
A 1 848 ALA 848 842 842 ALA ALA A . n 
A 1 849 GLU 849 843 843 GLU GLU A . n 
A 1 850 ALA 850 844 844 ALA ALA A . n 
A 1 851 SER 851 845 845 SER SER A . n 
A 1 852 TYR 852 846 846 TYR TYR A . n 
A 1 853 GLU 853 847 847 GLU GLU A . n 
A 1 854 LEU 854 848 848 LEU LEU A . n 
A 1 855 VAL 855 849 849 VAL VAL A . n 
A 1 856 GLY 856 850 850 GLY GLY A . n 
A 1 857 LEU 857 851 851 LEU LEU A . n 
A 1 858 SER 858 852 852 SER SER A . n 
A 1 859 PRO 859 853 853 PRO PRO A . n 
A 1 860 GLU 860 854 ?   ?   ?   A . n 
A 1 861 GLU 861 855 ?   ?   ?   A . n 
A 1 862 GLU 862 856 ?   ?   ?   A . n 
A 1 863 GLU 863 857 ?   ?   ?   A . n 
A 1 864 LEU 864 858 ?   ?   ?   A . n 
A 1 865 ALA 865 859 ?   ?   ?   A . n 
A 1 866 GLN 866 860 ?   ?   ?   A . n 
A 1 867 THR 867 861 ?   ?   ?   A . n 
A 1 868 ARG 868 862 ?   ?   ?   A . n 
A 1 869 ILE 869 863 ?   ?   ?   A . n 
A 1 870 LYS 870 864 ?   ?   ?   A . n 
A 1 871 ARG 871 865 ?   ?   ?   A . n 
A 1 872 LYS 872 866 ?   ?   ?   A . n 
A 1 873 LYS 873 867 ?   ?   ?   A . n 
A 1 874 ARG 874 868 868 ARG ARG A . n 
A 1 875 GLU 875 869 869 GLU GLU A . n 
A 1 876 PRO 876 870 870 PRO PRO A . n 
A 1 877 PHE 877 871 871 PHE PHE A . n 
A 1 878 TYR 878 872 872 TYR TYR A . n 
A 1 879 ARG 879 873 873 ARG ARG A . n 
A 1 880 HIS 880 874 874 HIS HIS A . n 
A 1 881 GLU 881 875 875 GLU GLU A . n 
A 1 882 GLY 882 876 876 GLY GLY A . n 
A 1 883 VAL 883 877 877 VAL VAL A . n 
A 1 884 TRP 884 878 878 TRP TRP A . n 
A 1 885 LEU 885 879 879 LEU LEU A . n 
A 1 886 THR 886 880 880 THR THR A . n 
A 1 887 ARG 887 881 881 ARG ARG A . n 
A 1 888 GLU 888 882 882 GLU GLU A . n 
A 1 889 LYS 889 883 883 LYS LYS A . n 
A 1 890 HIS 890 884 884 HIS HIS A . n 
A 1 891 ARG 891 885 885 ARG ARG A . n 
A 1 892 GLU 892 886 886 GLU GLU A . n 
A 1 893 GLN 893 887 887 GLN GLN A . n 
A 1 894 VAL 894 888 888 VAL VAL A . n 
A 1 895 HIS 895 889 889 HIS HIS A . n 
A 1 896 GLU 896 890 890 GLU GLU A . n 
A 1 897 LEU 897 891 891 LEU LEU A . n 
A 1 898 ARG 898 892 892 ARG ARG A . n 
A 1 899 ASN 899 893 893 ASN ASN A . n 
A 1 900 GLN 900 894 894 GLN GLN A . n 
A 1 901 VAL 901 895 895 VAL VAL A . n 
A 1 902 LEU 902 896 896 LEU LEU A . n 
A 1 903 ALA 903 897 897 ALA ALA A . n 
A 1 904 LEU 904 898 898 LEU LEU A . n 
A 1 905 GLY 905 899 899 GLY GLY A . n 
A 1 906 ASN 906 900 900 ASN ASN A . n 
A 1 907 ALA 907 901 901 ALA ALA A . n 
A 1 908 LYS 908 902 902 LYS LYS A . n 
A 1 909 ILE 909 903 903 ILE ILE A . n 
A 1 910 PRO 910 904 904 PRO PRO A . n 
A 1 911 GLU 911 905 905 GLU GLU A . n 
A 1 912 ILE 912 906 906 ILE ILE A . n 
A 1 913 ARG 913 907 907 ARG ARG A . n 
A 1 914 THR 914 908 908 THR THR A . n 
B 2 1   G   1   -36 -36 G   G   B . n 
B 2 2   U   2   -35 -35 U   U   B . n 
B 2 3   G   3   -34 -34 G   G   B . n 
B 2 4   C   4   -33 -33 C   C   B . n 
B 2 5   U   5   -32 -32 U   U   B . n 
B 2 6   G   6   -31 -31 G   G   B . n 
B 2 7   C   7   -30 -30 C   C   B . n 
B 2 8   U   8   -29 -29 U   U   B . n 
B 2 9   G   9   -28 -28 G   G   B . n 
B 2 10  U   10  -27 -27 U   U   B . n 
B 2 11  C   11  -26 -26 C   C   B . n 
B 2 12  U   12  -25 -25 U   U   B . n 
B 2 13  C   13  -24 -24 C   C   B . n 
B 2 14  C   14  -23 -23 C   C   B . n 
B 2 15  C   15  -22 -22 C   C   B . n 
B 2 16  A   16  -21 -21 A   A   B . n 
B 2 17  G   17  -20 -20 G   G   B . n 
B 2 18  A   18  -19 -19 A   A   B . n 
B 2 19  C   19  -18 -18 C   C   B . n 
B 2 20  G   20  -17 -17 G   G   B . n 
B 2 21  G   21  -16 -16 G   G   B . n 
B 2 22  G   22  -15 -15 G   G   B . n 
B 2 23  A   23  -14 -14 A   A   B . n 
B 2 24  G   24  -13 -13 G   G   B . n 
B 2 25  G   25  -12 -12 G   G   B . n 
B 2 26  C   26  -11 -11 C   C   B . n 
B 2 27  A   27  -10 -10 A   A   B . n 
B 2 28  G   28  -9  -9  G   G   B . n 
B 2 29  A   29  -8  -8  A   A   B . n 
B 2 30  A   30  -7  -7  A   A   B . n 
B 2 31  C   31  -6  -6  C   C   B . n 
B 2 32  U   32  -5  -5  U   U   B . n 
B 2 33  G   33  -4  -4  G   G   B . n 
B 2 34  C   34  -3  -3  C   C   B . n 
B 2 35  A   35  -2  -2  A   A   B . n 
B 2 36  C   36  -1  -1  C   C   B . n 
B 2 37  C   37  0   0   C   C   B . n 
B 2 38  U   38  1   1   U   U   B . n 
B 2 39  U   39  2   2   U   U   B . n 
B 2 40  C   40  3   3   C   C   B . n 
B 2 41  C   41  4   ?   ?   ?   B . n 
B 2 42  A   42  5   ?   ?   ?   B . n 
B 2 43  U   43  6   ?   ?   ?   B . n 
B 2 44  C   44  7   ?   ?   ?   B . n 
B 2 45  A   45  8   ?   ?   ?   B . n 
B 2 46  G   46  9   ?   ?   ?   B . n 
B 2 47  A   47  10  ?   ?   ?   B . n 
B 2 48  G   48  11  ?   ?   ?   B . n 
B 2 49  A   49  12  ?   ?   ?   B . n 
B 2 50  A   50  13  ?   ?   ?   B . n 
B 2 51  C   51  14  ?   ?   ?   B . n 
B 2 52  C   52  15  ?   ?   ?   B . n 
B 2 53  U   53  16  ?   ?   ?   B . n 
B 2 54  C   54  17  ?   ?   ?   B . n 
B 2 55  A   55  18  ?   ?   ?   B . n 
B 2 56  C   56  19  ?   ?   ?   B . n 
B 2 57  U   57  20  ?   ?   ?   B . n 
B 2 58  G   58  21  ?   ?   ?   B . n 
B 2 59  C   59  22  ?   ?   ?   B . n 
B 2 60  G   60  23  ?   ?   ?   B . n 
C 3 1   DC  1   -33 ?   ?   ?   C . n 
C 3 2   DA  2   -32 ?   ?   ?   C . n 
C 3 3   DA  3   -31 ?   ?   ?   C . n 
C 3 4   DG  4   -30 ?   ?   ?   C . n 
C 3 5   DC  5   -29 ?   ?   ?   C . n 
C 3 6   DC  6   -28 ?   ?   ?   C . n 
C 3 7   DG  7   -27 ?   ?   ?   C . n 
C 3 8   DT  8   -26 ?   ?   ?   C . n 
C 3 9   DC  9   -25 ?   ?   ?   C . n 
C 3 10  DT  10  -24 ?   ?   ?   C . n 
C 3 11  DA  11  -23 ?   ?   ?   C . n 
C 3 12  DG  12  -22 ?   ?   ?   C . n 
C 3 13  DC  13  -21 ?   ?   ?   C . n 
C 3 14  DG  14  -20 ?   ?   ?   C . n 
C 3 15  DG  15  -19 ?   ?   ?   C . n 
C 3 16  DT  16  -18 ?   ?   ?   C . n 
C 3 17  DG  17  -17 ?   ?   ?   C . n 
C 3 18  DA  18  -16 ?   ?   ?   C . n 
C 3 19  DG  19  -15 ?   ?   ?   C . n 
C 3 20  DG  20  -14 ?   ?   ?   C . n 
C 3 21  DT  21  -13 ?   ?   ?   C . n 
C 3 22  DT  22  -12 ?   ?   ?   C . n 
C 3 23  DC  23  -11 ?   ?   ?   C . n 
C 3 24  DT  24  -10 ?   ?   ?   C . n 
C 3 25  DC  25  -9  ?   ?   ?   C . n 
C 3 26  DT  26  -8  ?   ?   ?   C . n 
C 3 27  DG  27  -7  ?   ?   ?   C . n 
C 3 28  DA  28  -6  ?   ?   ?   C . n 
C 3 29  DT  29  -5  ?   ?   ?   C . n 
C 3 30  DG  30  -4  ?   ?   ?   C . n 
C 3 31  DG  31  -3  ?   ?   ?   C . n 
C 3 32  DA  32  -2  -2  DA  DA  C . n 
C 3 33  DA  33  -1  -1  DA  DA  C . n 
C 3 34  DG  34  0   0   DG  DG  C . n 
C 3 35  DC  35  1   1   DC  DC  C . n 
C 3 36  DA  36  2   2   DA  DA  C . n 
C 3 37  DT  37  3   3   DT  DT  C . n 
C 3 38  DA  38  4   4   DA  DA  C . n 
C 3 39  DT  39  5   5   DT  DT  C . n 
C 3 40  DC  40  6   6   DC  DC  C . n 
C 3 41  DG  41  7   7   DG  DG  C . n 
C 3 42  DT  42  8   8   DT  DT  C . n 
C 3 43  DA  43  9   ?   ?   ?   C . n 
C 3 44  DG  44  10  ?   ?   ?   C . n 
D 4 1   DC  1   -1  ?   ?   ?   D . n 
D 4 2   DT  2   0   ?   ?   ?   D . n 
D 4 3   DA  3   1   ?   ?   ?   D . n 
D 4 4   DC  4   2   2   DC  DC  D . n 
D 4 5   DG  5   3   3   DG  DG  D . n 
D 4 6   DA  6   4   4   DA  DA  D . n 
D 4 7   DT  7   5   5   DT  DT  D . n 
D 4 8   DA  8   6   6   DA  DA  D . n 
D 4 9   DT  9   7   7   DT  DT  D . n 
D 4 10  DG  10  8   8   DG  DG  D . n 
D 4 11  DC  11  9   ?   ?   ?   D . n 
D 4 12  DT  12  10  ?   ?   ?   D . n 
D 4 13  DT  13  11  ?   ?   ?   D . n 
D 4 14  DC  14  12  ?   ?   ?   D . n 
D 4 15  DC  15  13  ?   ?   ?   D . n 
D 4 16  DA  16  14  ?   ?   ?   D . n 
D 4 17  DT  17  15  ?   ?   ?   D . n 
D 4 18  DC  18  16  ?   ?   ?   D . n 
D 4 19  DA  19  17  ?   ?   ?   D . n 
D 4 20  DG  20  18  ?   ?   ?   D . n 
D 4 21  DA  21  19  ?   ?   ?   D . n 
D 4 22  DG  22  20  ?   ?   ?   D . n 
D 4 23  DA  23  21  ?   ?   ?   D . n 
D 4 24  DA  24  22  ?   ?   ?   D . n 
D 4 25  DC  25  23  ?   ?   ?   D . n 
D 4 26  DC  26  24  ?   ?   ?   D . n 
D 4 27  DT  27  25  ?   ?   ?   D . n 
D 4 28  DC  28  26  ?   ?   ?   D . n 
D 4 29  DA  29  27  ?   ?   ?   D . n 
D 4 30  DC  30  28  ?   ?   ?   D . n 
D 4 31  DC  31  29  ?   ?   ?   D . n 
D 4 32  DG  32  30  ?   ?   ?   D . n 
D 4 33  DC  33  31  ?   ?   ?   D . n 
D 4 34  DT  34  32  ?   ?   ?   D . n 
D 4 35  DA  35  33  ?   ?   ?   D . n 
D 4 36  DG  36  34  ?   ?   ?   D . n 
D 4 37  DA  37  35  ?   ?   ?   D . n 
D 4 38  DC  38  36  ?   ?   ?   D . n 
D 4 39  DG  39  37  ?   ?   ?   D . n 
D 4 40  DG  40  38  ?   ?   ?   D . n 
D 4 41  DC  41  39  ?   ?   ?   D . n 
D 4 42  DT  42  40  ?   ?   ?   D . n 
D 4 43  DT  43  41  ?   ?   ?   D . n 
D 4 44  DG  44  42  ?   ?   ?   D . n 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A ARG 652 ? CG  ? A ARG 658 CG  
2 1 Y 1 A ARG 652 ? CD  ? A ARG 658 CD  
3 1 Y 1 A ARG 652 ? NE  ? A ARG 658 NE  
4 1 Y 1 A ARG 652 ? CZ  ? A ARG 658 CZ  
5 1 Y 1 A ARG 652 ? NH1 ? A ARG 658 NH1 
6 1 Y 1 A ARG 652 ? NH2 ? A ARG 658 NH2 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZQS 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     8ZQS 
_struct.title                        'Cryo-EM structure of Cas12X with crRNA and Target DNA, Conformation 1' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZQS 
_struct_keywords.text            'Crispr-Cas12, RNA BINDING PROTEIN/RNA/DNA, RNA BINDING PROTEIN-RNA-DNA complex' 
_struct_keywords.pdbx_keywords   'RNA BINDING PROTEIN/RNA/DNA' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8ZQS 8ZQS ? 1 ? 1 
2 PDB 8ZQS 8ZQS ? 2 ? 1 
3 PDB 8ZQS 8ZQS ? 3 ? 1 
4 PDB 8ZQS 8ZQS ? 4 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZQS A 1 ? 914 ? 8ZQS -5  ? 908 ? -5  908 
2 2 8ZQS B 1 ? 60  ? 8ZQS -36 ? 23  ? -36 23  
3 3 8ZQS C 1 ? 44  ? 8ZQS -33 ? 10  ? -33 10  
4 4 8ZQS D 1 ? 44  ? 8ZQS -1  ? 42  ? -1  42  
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 31  ? ALA A 44  ? SER A 25  ALA A 38  1 ? 14 
HELX_P HELX_P2  AA2 PRO A 79  ? ALA A 81  ? PRO A 73  ALA A 75  5 ? 3  
HELX_P HELX_P3  AA3 VAL A 82  ? VAL A 93  ? VAL A 76  VAL A 87  1 ? 12 
HELX_P HELX_P4  AA4 ALA A 198 ? ARG A 205 ? ALA A 192 ARG A 199 1 ? 8  
HELX_P HELX_P5  AA5 ASP A 219 ? ARG A 231 ? ASP A 213 ARG A 225 1 ? 13 
HELX_P HELX_P6  AA6 SER A 453 ? ALA A 465 ? SER A 447 ALA A 459 1 ? 13 
HELX_P HELX_P7  AA7 SER A 528 ? ARG A 558 ? SER A 522 ARG A 552 1 ? 31 
HELX_P HELX_P8  AA8 ASN A 562 ? LYS A 572 ? ASN A 556 LYS A 566 1 ? 11 
HELX_P HELX_P9  AA9 LYS A 572 ? ARG A 578 ? LYS A 566 ARG A 572 1 ? 7  
HELX_P HELX_P10 AB1 ASP A 584 ? LEU A 612 ? ASP A 578 LEU A 606 1 ? 29 
HELX_P HELX_P11 AB2 ARG A 613 ? HIS A 615 ? ARG A 607 HIS A 609 5 ? 3  
HELX_P HELX_P12 AB3 THR A 616 ? ASP A 620 ? THR A 610 ASP A 614 5 ? 5  
HELX_P HELX_P13 AB4 ALA A 627 ? ARG A 648 ? ALA A 621 ARG A 642 1 ? 22 
HELX_P HELX_P14 AB5 LEU A 666 ? HIS A 695 ? LEU A 660 HIS A 689 1 ? 30 
HELX_P HELX_P15 AB6 ALA A 727 ? GLU A 742 ? ALA A 721 GLU A 736 1 ? 16 
HELX_P HELX_P16 AB7 ASP A 789 ? THR A 802 ? ASP A 783 THR A 796 1 ? 14 
HELX_P HELX_P17 AB8 ARG A 826 ? THR A 837 ? ARG A 820 THR A 831 1 ? 12 
HELX_P HELX_P18 AB9 ARG A 887 ? GLY A 905 ? ARG A 881 GLY A 899 1 ? 19 
HELX_P HELX_P19 AC1 ASN A 906 ? ILE A 909 ? ASN A 900 ILE A 903 5 ? 4  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
hydrog1  hydrog ? ? B G  1  N1 ? ? ? 1_555 B C  36 N3 ? ? B G  -36 B C  -1  1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog2  hydrog ? ? B G  1  N2 ? ? ? 1_555 B C  36 O2 ? ? B G  -36 B C  -1  1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog3  hydrog ? ? B G  1  O6 ? ? ? 1_555 B C  36 N4 ? ? B G  -36 B C  -1  1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog4  hydrog ? ? B U  2  N3 ? ? ? 1_555 B A  35 N1 ? ? B U  -35 B A  -2  1_555 ? ? ? ? ? ? 'U-A PAIR'     ? ? ? 
hydrog5  hydrog ? ? B G  3  N1 ? ? ? 1_555 B C  34 N3 ? ? B G  -34 B C  -3  1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog6  hydrog ? ? B G  3  N2 ? ? ? 1_555 B C  34 O2 ? ? B G  -34 B C  -3  1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog7  hydrog ? ? B G  3  O6 ? ? ? 1_555 B C  34 N4 ? ? B G  -34 B C  -3  1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog8  hydrog ? ? B C  4  N3 ? ? ? 1_555 B G  33 N1 ? ? B C  -33 B G  -4  1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog9  hydrog ? ? B C  4  N4 ? ? ? 1_555 B G  33 O6 ? ? B C  -33 B G  -4  1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog10 hydrog ? ? B C  4  O2 ? ? ? 1_555 B G  33 N2 ? ? B C  -33 B G  -4  1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog11 hydrog ? ? B U  5  O4 ? ? ? 1_555 B G  33 N1 ? ? B U  -32 B G  -4  1_555 ? ? ? ? ? ? 'U-G MISPAIR'  ? ? ? 
hydrog12 hydrog ? ? B G  6  N1 ? ? ? 1_555 B A  29 N1 ? ? B G  -31 B A  -8  1_555 ? ? ? ? ? ? TYPE_8_PAIR    ? ? ? 
hydrog13 hydrog ? ? B G  6  O6 ? ? ? 1_555 B A  29 N6 ? ? B G  -31 B A  -8  1_555 ? ? ? ? ? ? TYPE_8_PAIR    ? ? ? 
hydrog14 hydrog ? ? B C  7  N3 ? ? ? 1_555 B G  28 N1 ? ? B C  -30 B G  -9  1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog15 hydrog ? ? B C  7  N4 ? ? ? 1_555 B G  28 O6 ? ? B C  -30 B G  -9  1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog16 hydrog ? ? B C  7  O2 ? ? ? 1_555 B G  28 N2 ? ? B C  -30 B G  -9  1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog17 hydrog ? ? B U  8  N3 ? ? ? 1_555 B A  27 N1 ? ? B U  -29 B A  -10 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog18 hydrog ? ? B U  8  O4 ? ? ? 1_555 B A  27 N6 ? ? B U  -29 B A  -10 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog19 hydrog ? ? B G  9  N1 ? ? ? 1_555 B C  26 N3 ? ? B G  -28 B C  -11 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog20 hydrog ? ? B G  9  N2 ? ? ? 1_555 B C  26 O2 ? ? B G  -28 B C  -11 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog21 hydrog ? ? B G  9  O6 ? ? ? 1_555 B C  26 N4 ? ? B G  -28 B C  -11 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog22 hydrog ? ? B U  10 N3 ? ? ? 1_555 B G  25 O6 ? ? B U  -27 B G  -12 1_555 ? ? ? ? ? ? TYPE_28_PAIR   ? ? ? 
hydrog23 hydrog ? ? B U  10 O2 ? ? ? 1_555 B G  25 N1 ? ? B U  -27 B G  -12 1_555 ? ? ? ? ? ? TYPE_28_PAIR   ? ? ? 
hydrog24 hydrog ? ? B C  11 N3 ? ? ? 1_555 B G  24 N1 ? ? B C  -26 B G  -13 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog25 hydrog ? ? B C  11 N4 ? ? ? 1_555 B G  24 O6 ? ? B C  -26 B G  -13 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog26 hydrog ? ? B C  11 O2 ? ? ? 1_555 B G  24 N2 ? ? B C  -26 B G  -13 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog27 hydrog ? ? B U  12 O4 ? ? ? 1_555 B A  23 N6 ? ? B U  -25 B A  -14 1_555 ? ? ? ? ? ? 'U-A PAIR'     ? ? ? 
hydrog28 hydrog ? ? B C  13 N3 ? ? ? 1_555 B G  22 N1 ? ? B C  -24 B G  -15 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog29 hydrog ? ? B C  13 N4 ? ? ? 1_555 B G  22 O6 ? ? B C  -24 B G  -15 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog30 hydrog ? ? B C  13 O2 ? ? ? 1_555 B G  22 N2 ? ? B C  -24 B G  -15 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog31 hydrog ? ? B C  14 N3 ? ? ? 1_555 B G  21 N1 ? ? B C  -23 B G  -16 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog32 hydrog ? ? B C  14 N4 ? ? ? 1_555 B G  21 O6 ? ? B C  -23 B G  -16 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog33 hydrog ? ? B C  14 O2 ? ? ? 1_555 B G  21 N2 ? ? B C  -23 B G  -16 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog34 hydrog ? ? B C  15 N3 ? ? ? 1_555 B G  20 N1 ? ? B C  -22 B G  -17 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog35 hydrog ? ? B C  15 N4 ? ? ? 1_555 B G  20 O6 ? ? B C  -22 B G  -17 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog36 hydrog ? ? B C  15 O2 ? ? ? 1_555 B G  20 N2 ? ? B C  -22 B G  -17 1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog37 hydrog ? ? B A  16 N6 ? ? ? 1_555 B G  20 O6 ? ? B A  -21 B G  -17 1_555 ? ? ? ? ? ? TYPE_9_PAIR    ? ? ? 
hydrog38 hydrog ? ? B A  16 N7 ? ? ? 1_555 B G  20 N1 ? ? B A  -21 B G  -17 1_555 ? ? ? ? ? ? TYPE_9_PAIR    ? ? ? 
hydrog39 hydrog ? ? B C  37 N3 ? ? ? 1_555 C DG 34 N1 ? ? B C  0   C DG 0   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog40 hydrog ? ? B C  37 N4 ? ? ? 1_555 C DG 34 O6 ? ? B C  0   C DG 0   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog41 hydrog ? ? B C  37 O2 ? ? ? 1_555 C DG 34 N2 ? ? B C  0   C DG 0   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog42 hydrog ? ? B U  38 O4 ? ? ? 1_555 C DA 33 N6 ? ? B U  1   C DA -1  1_555 ? ? ? ? ? ? 'U-DA PAIR'    ? ? ? 
hydrog43 hydrog ? ? B C  40 N3 ? ? ? 1_555 C DA 32 N6 ? ? B C  3   C DA -2  1_555 ? ? ? ? ? ? 'C-DA MISPAIR' ? ? ? 
hydrog44 hydrog ? ? C DC 35 N4 ? ? ? 1_555 D DG 10 O6 ? ? C DC 1   D DG 8   1_555 ? ? ? ? ? ? 'DC-DG PAIR'   ? ? ? 
hydrog45 hydrog ? ? C DA 36 N6 ? ? ? 1_555 D DT 9  O4 ? ? C DA 2   D DT 7   1_555 ? ? ? ? ? ? 'DA-DT PAIR'   ? ? ? 
hydrog46 hydrog ? ? C DT 37 N3 ? ? ? 1_555 D DA 8  N1 ? ? C DT 3   D DA 6   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog47 hydrog ? ? C DT 37 O4 ? ? ? 1_555 D DA 8  N6 ? ? C DT 3   D DA 6   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog48 hydrog ? ? C DA 38 N1 ? ? ? 1_555 D DT 7  N3 ? ? C DA 4   D DT 5   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog49 hydrog ? ? C DA 38 N6 ? ? ? 1_555 D DT 7  O4 ? ? C DA 4   D DT 5   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog50 hydrog ? ? C DT 39 N3 ? ? ? 1_555 D DA 6  N1 ? ? C DT 5   D DA 4   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog51 hydrog ? ? C DT 39 O4 ? ? ? 1_555 D DA 6  N6 ? ? C DT 5   D DA 4   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog52 hydrog ? ? C DC 40 N3 ? ? ? 1_555 D DG 5  N1 ? ? C DC 6   D DG 3   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog53 hydrog ? ? C DC 40 N4 ? ? ? 1_555 D DG 5  O6 ? ? C DC 6   D DG 3   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog54 hydrog ? ? C DC 40 O2 ? ? ? 1_555 D DG 5  N2 ? ? C DC 6   D DG 3   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog55 hydrog ? ? C DG 41 N1 ? ? ? 1_555 D DC 4  N3 ? ? C DG 7   D DC 2   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog56 hydrog ? ? C DG 41 N2 ? ? ? 1_555 D DC 4  O2 ? ? C DG 7   D DC 2   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
hydrog57 hydrog ? ? C DG 41 O6 ? ? ? 1_555 D DC 4  N4 ? ? C DG 7   D DC 2   1_555 ? ? ? ? ? ? WATSON-CRICK   ? ? ? 
# 
_struct_conn_type.id          hydrog 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 5 ? 
AA5 ? 2 ? 
AA6 ? 3 ? 
AA7 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? parallel      
AA4 4 5 ? parallel      
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA7 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 10  ? LYS A 11  ? TYR A 4   LYS A 5   
AA1 2 ARG A 438 ? ASN A 446 ? ARG A 432 ASN A 440 
AA1 3 ARG A 422 ? GLN A 435 ? ARG A 416 GLN A 429 
AA1 4 VAL A 355 ? GLY A 358 ? VAL A 349 GLY A 352 
AA2 1 ARG A 14  ? VAL A 17  ? ARG A 8   VAL A 11  
AA2 2 ARG A 438 ? ASN A 446 ? ARG A 432 ASN A 440 
AA2 3 ARG A 422 ? GLN A 435 ? ARG A 416 GLN A 429 
AA2 4 PHE A 409 ? THR A 414 ? PHE A 403 THR A 408 
AA2 5 TRP A 397 ? ARG A 403 ? TRP A 391 ARG A 397 
AA3 1 PHE A 366 ? ALA A 371 ? PHE A 360 ALA A 365 
AA3 2 ARG A 374 ? LYS A 380 ? ARG A 368 LYS A 374 
AA3 3 ASP A 385 ? THR A 389 ? ASP A 379 THR A 383 
AA4 1 THR A 520 ? ARG A 523 ? THR A 514 ARG A 517 
AA4 2 PHE A 491 ? THR A 497 ? PHE A 485 THR A 491 
AA4 3 THR A 479 ? LEU A 485 ? THR A 473 LEU A 479 
AA4 4 LEU A 699 ? GLU A 703 ? LEU A 693 GLU A 697 
AA4 5 LEU A 745 ? VAL A 749 ? LEU A 739 VAL A 743 
AA5 1 ILE A 505 ? SER A 507 ? ILE A 499 SER A 501 
AA5 2 VAL A 515 ? PHE A 517 ? VAL A 509 PHE A 511 
AA6 1 TYR A 766 ? ARG A 767 ? TYR A 760 ARG A 761 
AA6 2 THR A 774 ? GLN A 779 ? THR A 768 GLN A 773 
AA6 3 LYS A 782 ? ASP A 787 ? LYS A 776 ASP A 781 
AA7 1 THR A 843 ? LEU A 844 ? THR A 837 LEU A 838 
AA7 2 TYR A 820 ? VAL A 822 ? TYR A 814 VAL A 816 
AA7 3 GLN A 809 ? LEU A 814 ? GLN A 803 LEU A 808 
AA7 4 GLU A 875 ? TYR A 878 ? GLU A 869 TYR A 872 
AA7 5 LEU A 885 ? THR A 886 ? LEU A 879 THR A 880 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LYS A 11  ? N LYS A 5   O TYR A 445 ? O TYR A 439 
AA1 2 3 O PHE A 442 ? O PHE A 436 N GLY A 431 ? N GLY A 425 
AA1 3 4 O LEU A 432 ? O LEU A 426 N VAL A 355 ? N VAL A 349 
AA2 1 2 N VAL A 15  ? N VAL A 9   O PHE A 441 ? O PHE A 435 
AA2 2 3 O PHE A 442 ? O PHE A 436 N GLY A 431 ? N GLY A 425 
AA2 3 4 O VAL A 427 ? O VAL A 421 N PHE A 409 ? N PHE A 403 
AA2 4 5 O ARG A 410 ? O ARG A 404 N GLY A 402 ? N GLY A 396 
AA3 1 2 N SER A 369 ? N SER A 363 O LEU A 376 ? O LEU A 370 
AA3 2 3 N ILE A 377 ? N ILE A 371 O LEU A 388 ? O LEU A 382 
AA4 1 2 O GLY A 521 ? O GLY A 515 N PHE A 493 ? N PHE A 487 
AA4 2 3 O CYS A 496 ? O CYS A 490 N VAL A 480 ? N VAL A 474 
AA4 3 4 N ILE A 483 ? N ILE A 477 O ALA A 701 ? O ALA A 695 
AA4 4 5 N MET A 702 ? N MET A 696 O VAL A 749 ? O VAL A 743 
AA5 1 2 N SER A 507 ? N SER A 501 O VAL A 515 ? O VAL A 509 
AA6 1 2 N TYR A 766 ? N TYR A 760 O TYR A 776 ? O TYR A 770 
AA6 2 3 N PHE A 775 ? N PHE A 769 O ILE A 786 ? O ILE A 780 
AA7 1 2 O LEU A 844 ? O LEU A 838 N TYR A 820 ? N TYR A 814 
AA7 2 3 O LEU A 821 ? O LEU A 815 N SER A 813 ? N SER A 807 
AA7 3 4 N ALA A 812 ? N ALA A 806 O GLU A 875 ? O GLU A 869 
AA7 4 5 N TYR A 878 ? N TYR A 872 O LEU A 885 ? O LEU A 879 
# 
_pdbx_entry_details.entry_id                   8ZQS 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 HIS A 209 ? ? -38.97  95.87   
2  1 ASP A 211 ? ? 48.49   -100.12 
3  1 LEU A 212 ? ? -132.19 -125.12 
4  1 ASP A 213 ? ? 12.96   -80.67  
5  1 HIS A 609 ? ? -140.62 36.05   
6  1 THR A 646 ? ? -125.58 -167.47 
7  1 ARG A 650 ? ? 59.67   -143.78 
8  1 SER A 718 ? ? 70.17   -3.75   
9  1 PRO A 745 ? ? -93.36  53.51   
10 1 GLU A 843 ? ? -92.03  50.23   
11 1 HIS A 874 ? ? 55.76   -139.29 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8ZQS 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8ZQS 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.40 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               47335 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               'MULTIPLE SOURCES' 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Ternary complex of Cas12X with crRNA and Target DNA' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3, 4' 
# 
_em_imaging.entry_id                        8ZQS 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1200 
_em_imaging.nominal_defocus_max             5000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8ZQS 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8ZQS 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A HIS -5  ? A HIS 1   
2   1 Y 1 A HIS -4  ? A HIS 2   
3   1 Y 1 A HIS -3  ? A HIS 3   
4   1 Y 1 A HIS -2  ? A HIS 4   
5   1 Y 1 A HIS -1  ? A HIS 5   
6   1 Y 1 A HIS 0   ? A HIS 6   
7   1 Y 1 A MET 1   ? A MET 7   
8   1 Y 1 A VAL 14  ? A VAL 20  
9   1 Y 1 A PRO 15  ? A PRO 21  
10  1 Y 1 A GLU 16  ? A GLU 22  
11  1 Y 1 A GLU 17  ? A GLU 23  
12  1 Y 1 A LEU 18  ? A LEU 24  
13  1 Y 1 A VAL 19  ? A VAL 25  
14  1 Y 1 A ASP 20  ? A ASP 26  
15  1 Y 1 A HIS 21  ? A HIS 27  
16  1 Y 1 A TYR 22  ? A TYR 28  
17  1 Y 1 A GLU 23  ? A GLU 29  
18  1 Y 1 A MET 39  ? A MET 45  
19  1 Y 1 A ARG 40  ? A ARG 46  
20  1 Y 1 A ARG 41  ? A ARG 47  
21  1 Y 1 A GLU 42  ? A GLU 48  
22  1 Y 1 A PRO 43  ? A PRO 49  
23  1 Y 1 A TYR 44  ? A TYR 50  
24  1 Y 1 A SER 45  ? A SER 51  
25  1 Y 1 A LEU 46  ? A LEU 52  
26  1 Y 1 A ARG 47  ? A ARG 53  
27  1 Y 1 A MET 48  ? A MET 54  
28  1 Y 1 A ARG 49  ? A ARG 55  
29  1 Y 1 A ASP 50  ? A ASP 56  
30  1 Y 1 A GLY 51  ? A GLY 57  
31  1 Y 1 A THR 52  ? A THR 58  
32  1 Y 1 A GLU 53  ? A GLU 59  
33  1 Y 1 A ARG 54  ? A ARG 60  
34  1 Y 1 A GLU 55  ? A GLU 61  
35  1 Y 1 A VAL 56  ? A VAL 62  
36  1 Y 1 A ASP 57  ? A ASP 63  
37  1 Y 1 A LEU 58  ? A LEU 64  
38  1 Y 1 A ASP 59  ? A ASP 65  
39  1 Y 1 A GLU 60  ? A GLU 66  
40  1 Y 1 A THR 61  ? A THR 67  
41  1 Y 1 A ASP 62  ? A ASP 68  
42  1 Y 1 A ASP 63  ? A ASP 69  
43  1 Y 1 A PHE 64  ? A PHE 70  
44  1 Y 1 A LEU 65  ? A LEU 71  
45  1 Y 1 A ARG 66  ? A ARG 72  
46  1 Y 1 A SER 67  ? A SER 73  
47  1 Y 1 A ALA 68  ? A ALA 74  
48  1 Y 1 A LEU 88  ? A LEU 94  
49  1 Y 1 A HIS 89  ? A HIS 95  
50  1 Y 1 A GLN 90  ? A GLN 96  
51  1 Y 1 A ASP 91  ? A ASP 97  
52  1 Y 1 A ASN 92  ? A ASN 98  
53  1 Y 1 A PRO 93  ? A PRO 99  
54  1 Y 1 A LYS 94  ? A LYS 100 
55  1 Y 1 A LYS 95  ? A LYS 101 
56  1 Y 1 A ARG 96  ? A ARG 102 
57  1 Y 1 A ALA 97  ? A ALA 103 
58  1 Y 1 A PHE 98  ? A PHE 104 
59  1 Y 1 A LEU 99  ? A LEU 105 
60  1 Y 1 A GLU 100 ? A GLU 106 
61  1 Y 1 A SER 101 ? A SER 107 
62  1 Y 1 A GLU 102 ? A GLU 108 
63  1 Y 1 A ASN 103 ? A ASN 109 
64  1 Y 1 A CYS 104 ? A CYS 110 
65  1 Y 1 A VAL 105 ? A VAL 111 
66  1 Y 1 A SER 106 ? A SER 112 
67  1 Y 1 A ILE 107 ? A ILE 113 
68  1 Y 1 A LEU 108 ? A LEU 114 
69  1 Y 1 A CYS 109 ? A CYS 115 
70  1 Y 1 A LEU 110 ? A LEU 116 
71  1 Y 1 A GLU 111 ? A GLU 117 
72  1 Y 1 A LYS 112 ? A LYS 118 
73  1 Y 1 A SER 113 ? A SER 119 
74  1 Y 1 A ALA 114 ? A ALA 120 
75  1 Y 1 A SER 115 ? A SER 121 
76  1 Y 1 A GLY 116 ? A GLY 122 
77  1 Y 1 A THR 117 ? A THR 123 
78  1 Y 1 A ARG 118 ? A ARG 124 
79  1 Y 1 A TYR 119 ? A TYR 125 
80  1 Y 1 A TYR 120 ? A TYR 126 
81  1 Y 1 A LYS 121 ? A LYS 127 
82  1 Y 1 A ARG 122 ? A ARG 128 
83  1 Y 1 A PRO 123 ? A PRO 129 
84  1 Y 1 A GLY 124 ? A GLY 130 
85  1 Y 1 A TYR 125 ? A TYR 131 
86  1 Y 1 A GLN 126 ? A GLN 132 
87  1 Y 1 A LEU 127 ? A LEU 133 
88  1 Y 1 A LEU 128 ? A LEU 134 
89  1 Y 1 A LYS 129 ? A LYS 135 
90  1 Y 1 A LYS 130 ? A LYS 136 
91  1 Y 1 A ALA 131 ? A ALA 137 
92  1 Y 1 A ILE 132 ? A ILE 138 
93  1 Y 1 A GLU 133 ? A GLU 139 
94  1 Y 1 A GLU 134 ? A GLU 140 
95  1 Y 1 A GLU 135 ? A GLU 141 
96  1 Y 1 A TRP 136 ? A TRP 142 
97  1 Y 1 A GLY 137 ? A GLY 143 
98  1 Y 1 A TRP 138 ? A TRP 144 
99  1 Y 1 A ASP 139 ? A ASP 145 
100 1 Y 1 A LYS 140 ? A LYS 146 
101 1 Y 1 A PHE 141 ? A PHE 147 
102 1 Y 1 A GLU 142 ? A GLU 148 
103 1 Y 1 A ALA 143 ? A ALA 149 
104 1 Y 1 A SER 144 ? A SER 150 
105 1 Y 1 A LEU 145 ? A LEU 151 
106 1 Y 1 A LEU 146 ? A LEU 152 
107 1 Y 1 A ASP 147 ? A ASP 153 
108 1 Y 1 A GLU 148 ? A GLU 154 
109 1 Y 1 A ARG 149 ? A ARG 155 
110 1 Y 1 A THR 150 ? A THR 156 
111 1 Y 1 A GLY 151 ? A GLY 157 
112 1 Y 1 A GLU 152 ? A GLU 158 
113 1 Y 1 A VAL 153 ? A VAL 159 
114 1 Y 1 A ALA 154 ? A ALA 160 
115 1 Y 1 A GLU 155 ? A GLU 161 
116 1 Y 1 A LYS 156 ? A LYS 162 
117 1 Y 1 A PHE 157 ? A PHE 163 
118 1 Y 1 A ALA 158 ? A ALA 164 
119 1 Y 1 A ALA 159 ? A ALA 165 
120 1 Y 1 A LEU 160 ? A LEU 166 
121 1 Y 1 A SER 161 ? A SER 167 
122 1 Y 1 A MET 162 ? A MET 168 
123 1 Y 1 A GLU 163 ? A GLU 169 
124 1 Y 1 A ASP 164 ? A ASP 170 
125 1 Y 1 A TRP 165 ? A TRP 171 
126 1 Y 1 A ARG 166 ? A ARG 172 
127 1 Y 1 A ARG 167 ? A ARG 173 
128 1 Y 1 A PHE 168 ? A PHE 174 
129 1 Y 1 A PHE 169 ? A PHE 175 
130 1 Y 1 A ALA 170 ? A ALA 176 
131 1 Y 1 A ALA 171 ? A ALA 177 
132 1 Y 1 A ARG 172 ? A ARG 178 
133 1 Y 1 A ASP 173 ? A ASP 179 
134 1 Y 1 A PRO 174 ? A PRO 180 
135 1 Y 1 A ASP 175 ? A ASP 181 
136 1 Y 1 A ASP 176 ? A ASP 182 
137 1 Y 1 A LEU 177 ? A LEU 183 
138 1 Y 1 A GLY 178 ? A GLY 184 
139 1 Y 1 A ARG 179 ? A ARG 185 
140 1 Y 1 A GLU 180 ? A GLU 186 
141 1 Y 1 A LEU 181 ? A LEU 187 
142 1 Y 1 A LEU 182 ? A LEU 188 
143 1 Y 1 A LYS 183 ? A LYS 189 
144 1 Y 1 A THR 184 ? A THR 190 
145 1 Y 1 A ASP 185 ? A ASP 191 
146 1 Y 1 A THR 186 ? A THR 192 
147 1 Y 1 A ARG 187 ? A ARG 193 
148 1 Y 1 A GLU 188 ? A GLU 194 
149 1 Y 1 A GLY 189 ? A GLY 195 
150 1 Y 1 A MET 190 ? A MET 196 
151 1 Y 1 A LEU 226 ? A LEU 232 
152 1 Y 1 A LYS 227 ? A LYS 233 
153 1 Y 1 A SER 228 ? A SER 234 
154 1 Y 1 A TRP 229 ? A TRP 235 
155 1 Y 1 A LEU 230 ? A LEU 236 
156 1 Y 1 A ALA 231 ? A ALA 237 
157 1 Y 1 A CYS 232 ? A CYS 238 
158 1 Y 1 A ASN 233 ? A ASN 239 
159 1 Y 1 A GLN 234 ? A GLN 240 
160 1 Y 1 A ARG 235 ? A ARG 241 
161 1 Y 1 A ALA 236 ? A ALA 242 
162 1 Y 1 A VAL 237 ? A VAL 243 
163 1 Y 1 A ASP 238 ? A ASP 244 
164 1 Y 1 A GLU 239 ? A GLU 245 
165 1 Y 1 A LYS 240 ? A LYS 246 
166 1 Y 1 A SER 241 ? A SER 247 
167 1 Y 1 A GLU 242 ? A GLU 248 
168 1 Y 1 A LEU 243 ? A LEU 249 
169 1 Y 1 A ARG 244 ? A ARG 250 
170 1 Y 1 A LYS 245 ? A LYS 251 
171 1 Y 1 A ARG 246 ? A ARG 252 
172 1 Y 1 A PHE 247 ? A PHE 253 
173 1 Y 1 A GLU 248 ? A GLU 254 
174 1 Y 1 A GLU 249 ? A GLU 255 
175 1 Y 1 A ALA 250 ? A ALA 256 
176 1 Y 1 A LEU 251 ? A LEU 257 
177 1 Y 1 A ASP 252 ? A ASP 258 
178 1 Y 1 A GLY 253 ? A GLY 259 
179 1 Y 1 A VAL 254 ? A VAL 260 
180 1 Y 1 A ASP 255 ? A ASP 261 
181 1 Y 1 A PRO 256 ? A PRO 262 
182 1 Y 1 A GLU 257 ? A GLU 263 
183 1 Y 1 A LYS 258 ? A LYS 264 
184 1 Y 1 A TYR 259 ? A TYR 265 
185 1 Y 1 A ALA 260 ? A ALA 266 
186 1 Y 1 A LEU 261 ? A LEU 267 
187 1 Y 1 A PHE 262 ? A PHE 268 
188 1 Y 1 A GLU 263 ? A GLU 269 
189 1 Y 1 A LYS 264 ? A LYS 270 
190 1 Y 1 A PHE 265 ? A PHE 271 
191 1 Y 1 A ALA 266 ? A ALA 272 
192 1 Y 1 A ALA 267 ? A ALA 273 
193 1 Y 1 A GLU 268 ? A GLU 274 
194 1 Y 1 A LEU 269 ? A LEU 275 
195 1 Y 1 A GLN 270 ? A GLN 276 
196 1 Y 1 A GLN 271 ? A GLN 277 
197 1 Y 1 A ALA 272 ? A ALA 278 
198 1 Y 1 A ASP 273 ? A ASP 279 
199 1 Y 1 A TYR 274 ? A TYR 280 
200 1 Y 1 A ASN 275 ? A ASN 281 
201 1 Y 1 A VAL 276 ? A VAL 282 
202 1 Y 1 A THR 277 ? A THR 283 
203 1 Y 1 A LYS 278 ? A LYS 284 
204 1 Y 1 A LYS 279 ? A LYS 285 
205 1 Y 1 A LEU 280 ? A LEU 286 
206 1 Y 1 A VAL 281 ? A VAL 287 
207 1 Y 1 A LEU 282 ? A LEU 288 
208 1 Y 1 A ALA 283 ? A ALA 289 
209 1 Y 1 A VAL 284 ? A VAL 290 
210 1 Y 1 A SER 285 ? A SER 291 
211 1 Y 1 A ALA 286 ? A ALA 292 
212 1 Y 1 A LYS 287 ? A LYS 293 
213 1 Y 1 A PHE 288 ? A PHE 294 
214 1 Y 1 A PRO 289 ? A PRO 295 
215 1 Y 1 A ALA 290 ? A ALA 296 
216 1 Y 1 A THR 291 ? A THR 297 
217 1 Y 1 A GLU 292 ? A GLU 298 
218 1 Y 1 A PRO 293 ? A PRO 299 
219 1 Y 1 A SER 294 ? A SER 300 
220 1 Y 1 A GLU 295 ? A GLU 301 
221 1 Y 1 A PHE 296 ? A PHE 302 
222 1 Y 1 A LYS 297 ? A LYS 303 
223 1 Y 1 A ARG 298 ? A ARG 304 
224 1 Y 1 A GLY 299 ? A GLY 305 
225 1 Y 1 A VAL 300 ? A VAL 306 
226 1 Y 1 A GLU 301 ? A GLU 307 
227 1 Y 1 A ILE 302 ? A ILE 308 
228 1 Y 1 A LEU 303 ? A LEU 309 
229 1 Y 1 A LYS 304 ? A LYS 310 
230 1 Y 1 A GLU 305 ? A GLU 311 
231 1 Y 1 A ASP 306 ? A ASP 312 
232 1 Y 1 A GLY 307 ? A GLY 313 
233 1 Y 1 A TYR 308 ? A TYR 314 
234 1 Y 1 A LYS 309 ? A LYS 315 
235 1 Y 1 A PRO 310 ? A PRO 316 
236 1 Y 1 A LEU 311 ? A LEU 317 
237 1 Y 1 A TRP 312 ? A TRP 318 
238 1 Y 1 A GLU 313 ? A GLU 319 
239 1 Y 1 A ASP 314 ? A ASP 320 
240 1 Y 1 A PHE 315 ? A PHE 321 
241 1 Y 1 A ARG 316 ? A ARG 322 
242 1 Y 1 A GLU 317 ? A GLU 323 
243 1 Y 1 A LEU 318 ? A LEU 324 
244 1 Y 1 A GLY 319 ? A GLY 325 
245 1 Y 1 A PHE 320 ? A PHE 326 
246 1 Y 1 A VAL 321 ? A VAL 327 
247 1 Y 1 A TYR 322 ? A TYR 328 
248 1 Y 1 A LEU 323 ? A LEU 329 
249 1 Y 1 A ALA 324 ? A ALA 330 
250 1 Y 1 A GLU 325 ? A GLU 331 
251 1 Y 1 A ARG 326 ? A ARG 332 
252 1 Y 1 A LYS 327 ? A LYS 333 
253 1 Y 1 A TRP 328 ? A TRP 334 
254 1 Y 1 A GLU 329 ? A GLU 335 
255 1 Y 1 A ARG 330 ? A ARG 336 
256 1 Y 1 A ARG 331 ? A ARG 337 
257 1 Y 1 A ARG 332 ? A ARG 338 
258 1 Y 1 A GLY 333 ? A GLY 339 
259 1 Y 1 A GLY 334 ? A GLY 340 
260 1 Y 1 A ALA 335 ? A ALA 341 
261 1 Y 1 A ALA 336 ? A ALA 342 
262 1 Y 1 A VAL 337 ? A VAL 343 
263 1 Y 1 A THR 338 ? A THR 344 
264 1 Y 1 A LEU 339 ? A LEU 345 
265 1 Y 1 A CYS 340 ? A CYS 346 
266 1 Y 1 A ASP 341 ? A ASP 347 
267 1 Y 1 A ALA 342 ? A ALA 348 
268 1 Y 1 A ASP 343 ? A ASP 349 
269 1 Y 1 A ASP 344 ? A ASP 350 
270 1 Y 1 A SER 345 ? A SER 351 
271 1 Y 1 A PRO 346 ? A PRO 352 
272 1 Y 1 A ILE 347 ? A ILE 353 
273 1 Y 1 A GLY 355 ? A GLY 361 
274 1 Y 1 A ARG 356 ? A ARG 362 
275 1 Y 1 A ARG 410 ? A ARG 416 
276 1 Y 1 A THR 411 ? A THR 417 
277 1 Y 1 A THR 412 ? A THR 418 
278 1 Y 1 A VAL 702 ? A VAL 708 
279 1 Y 1 A ASP 703 ? A ASP 709 
280 1 Y 1 A ARG 704 ? A ARG 710 
281 1 Y 1 A ASP 705 ? A ASP 711 
282 1 Y 1 A ASP 706 ? A ASP 712 
283 1 Y 1 A GLU 707 ? A GLU 713 
284 1 Y 1 A VAL 708 ? A VAL 714 
285 1 Y 1 A LYS 709 ? A LYS 715 
286 1 Y 1 A ARG 710 ? A ARG 716 
287 1 Y 1 A ARG 711 ? A ARG 717 
288 1 Y 1 A LYS 712 ? A LYS 718 
289 1 Y 1 A GLU 854 ? A GLU 860 
290 1 Y 1 A GLU 855 ? A GLU 861 
291 1 Y 1 A GLU 856 ? A GLU 862 
292 1 Y 1 A GLU 857 ? A GLU 863 
293 1 Y 1 A LEU 858 ? A LEU 864 
294 1 Y 1 A ALA 859 ? A ALA 865 
295 1 Y 1 A GLN 860 ? A GLN 866 
296 1 Y 1 A THR 861 ? A THR 867 
297 1 Y 1 A ARG 862 ? A ARG 868 
298 1 Y 1 A ILE 863 ? A ILE 869 
299 1 Y 1 A LYS 864 ? A LYS 870 
300 1 Y 1 A ARG 865 ? A ARG 871 
301 1 Y 1 A LYS 866 ? A LYS 872 
302 1 Y 1 A LYS 867 ? A LYS 873 
303 1 Y 1 B C   4   ? B C   41  
304 1 Y 1 B A   5   ? B A   42  
305 1 Y 1 B U   6   ? B U   43  
306 1 Y 1 B C   7   ? B C   44  
307 1 Y 1 B A   8   ? B A   45  
308 1 Y 1 B G   9   ? B G   46  
309 1 Y 1 B A   10  ? B A   47  
310 1 Y 1 B G   11  ? B G   48  
311 1 Y 1 B A   12  ? B A   49  
312 1 Y 1 B A   13  ? B A   50  
313 1 Y 1 B C   14  ? B C   51  
314 1 Y 1 B C   15  ? B C   52  
315 1 Y 1 B U   16  ? B U   53  
316 1 Y 1 B C   17  ? B C   54  
317 1 Y 1 B A   18  ? B A   55  
318 1 Y 1 B C   19  ? B C   56  
319 1 Y 1 B U   20  ? B U   57  
320 1 Y 1 B G   21  ? B G   58  
321 1 Y 1 B C   22  ? B C   59  
322 1 Y 1 B G   23  ? B G   60  
323 1 Y 1 C DC  -33 ? C DC  1   
324 1 Y 1 C DA  -32 ? C DA  2   
325 1 Y 1 C DA  -31 ? C DA  3   
326 1 Y 1 C DG  -30 ? C DG  4   
327 1 Y 1 C DC  -29 ? C DC  5   
328 1 Y 1 C DC  -28 ? C DC  6   
329 1 Y 1 C DG  -27 ? C DG  7   
330 1 Y 1 C DT  -26 ? C DT  8   
331 1 Y 1 C DC  -25 ? C DC  9   
332 1 Y 1 C DT  -24 ? C DT  10  
333 1 Y 1 C DA  -23 ? C DA  11  
334 1 Y 1 C DG  -22 ? C DG  12  
335 1 Y 1 C DC  -21 ? C DC  13  
336 1 Y 1 C DG  -20 ? C DG  14  
337 1 Y 1 C DG  -19 ? C DG  15  
338 1 Y 1 C DT  -18 ? C DT  16  
339 1 Y 1 C DG  -17 ? C DG  17  
340 1 Y 1 C DA  -16 ? C DA  18  
341 1 Y 1 C DG  -15 ? C DG  19  
342 1 Y 1 C DG  -14 ? C DG  20  
343 1 Y 1 C DT  -13 ? C DT  21  
344 1 Y 1 C DT  -12 ? C DT  22  
345 1 Y 1 C DC  -11 ? C DC  23  
346 1 Y 1 C DT  -10 ? C DT  24  
347 1 Y 1 C DC  -9  ? C DC  25  
348 1 Y 1 C DT  -8  ? C DT  26  
349 1 Y 1 C DG  -7  ? C DG  27  
350 1 Y 1 C DA  -6  ? C DA  28  
351 1 Y 1 C DT  -5  ? C DT  29  
352 1 Y 1 C DG  -4  ? C DG  30  
353 1 Y 1 C DG  -3  ? C DG  31  
354 1 Y 1 C DA  9   ? C DA  43  
355 1 Y 1 C DG  10  ? C DG  44  
356 1 Y 1 D DC  -1  ? D DC  1   
357 1 Y 1 D DT  0   ? D DT  2   
358 1 Y 1 D DA  1   ? D DA  3   
359 1 Y 1 D DC  9   ? D DC  11  
360 1 Y 1 D DT  10  ? D DT  12  
361 1 Y 1 D DT  11  ? D DT  13  
362 1 Y 1 D DC  12  ? D DC  14  
363 1 Y 1 D DC  13  ? D DC  15  
364 1 Y 1 D DA  14  ? D DA  16  
365 1 Y 1 D DT  15  ? D DT  17  
366 1 Y 1 D DC  16  ? D DC  18  
367 1 Y 1 D DA  17  ? D DA  19  
368 1 Y 1 D DG  18  ? D DG  20  
369 1 Y 1 D DA  19  ? D DA  21  
370 1 Y 1 D DG  20  ? D DG  22  
371 1 Y 1 D DA  21  ? D DA  23  
372 1 Y 1 D DA  22  ? D DA  24  
373 1 Y 1 D DC  23  ? D DC  25  
374 1 Y 1 D DC  24  ? D DC  26  
375 1 Y 1 D DT  25  ? D DT  27  
376 1 Y 1 D DC  26  ? D DC  28  
377 1 Y 1 D DA  27  ? D DA  29  
378 1 Y 1 D DC  28  ? D DC  30  
379 1 Y 1 D DC  29  ? D DC  31  
380 1 Y 1 D DG  30  ? D DG  32  
381 1 Y 1 D DC  31  ? D DC  33  
382 1 Y 1 D DT  32  ? D DT  34  
383 1 Y 1 D DA  33  ? D DA  35  
384 1 Y 1 D DG  34  ? D DG  36  
385 1 Y 1 D DA  35  ? D DA  37  
386 1 Y 1 D DC  36  ? D DC  38  
387 1 Y 1 D DG  37  ? D DG  39  
388 1 Y 1 D DG  38  ? D DG  40  
389 1 Y 1 D DC  39  ? D DC  41  
390 1 Y 1 D DT  40  ? D DT  42  
391 1 Y 1 D DT  41  ? D DT  43  
392 1 Y 1 D DG  42  ? D DG  44  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A   OP3    O N N 1   
A   P      P N N 2   
A   OP1    O N N 3   
A   OP2    O N N 4   
A   "O5'"  O N N 5   
A   "C5'"  C N N 6   
A   "C4'"  C N R 7   
A   "O4'"  O N N 8   
A   "C3'"  C N S 9   
A   "O3'"  O N N 10  
A   "C2'"  C N R 11  
A   "O2'"  O N N 12  
A   "C1'"  C N R 13  
A   N9     N Y N 14  
A   C8     C Y N 15  
A   N7     N Y N 16  
A   C5     C Y N 17  
A   C6     C Y N 18  
A   N6     N N N 19  
A   N1     N Y N 20  
A   C2     C Y N 21  
A   N3     N Y N 22  
A   C4     C Y N 23  
A   HOP3   H N N 24  
A   HOP2   H N N 25  
A   "H5'"  H N N 26  
A   "H5''" H N N 27  
A   "H4'"  H N N 28  
A   "H3'"  H N N 29  
A   "HO3'" H N N 30  
A   "H2'"  H N N 31  
A   "HO2'" H N N 32  
A   "H1'"  H N N 33  
A   H8     H N N 34  
A   H61    H N N 35  
A   H62    H N N 36  
A   H2     H N N 37  
ALA N      N N N 38  
ALA CA     C N S 39  
ALA C      C N N 40  
ALA O      O N N 41  
ALA CB     C N N 42  
ALA OXT    O N N 43  
ALA H      H N N 44  
ALA H2     H N N 45  
ALA HA     H N N 46  
ALA HB1    H N N 47  
ALA HB2    H N N 48  
ALA HB3    H N N 49  
ALA HXT    H N N 50  
ARG N      N N N 51  
ARG CA     C N S 52  
ARG C      C N N 53  
ARG O      O N N 54  
ARG CB     C N N 55  
ARG CG     C N N 56  
ARG CD     C N N 57  
ARG NE     N N N 58  
ARG CZ     C N N 59  
ARG NH1    N N N 60  
ARG NH2    N N N 61  
ARG OXT    O N N 62  
ARG H      H N N 63  
ARG H2     H N N 64  
ARG HA     H N N 65  
ARG HB2    H N N 66  
ARG HB3    H N N 67  
ARG HG2    H N N 68  
ARG HG3    H N N 69  
ARG HD2    H N N 70  
ARG HD3    H N N 71  
ARG HE     H N N 72  
ARG HH11   H N N 73  
ARG HH12   H N N 74  
ARG HH21   H N N 75  
ARG HH22   H N N 76  
ARG HXT    H N N 77  
ASN N      N N N 78  
ASN CA     C N S 79  
ASN C      C N N 80  
ASN O      O N N 81  
ASN CB     C N N 82  
ASN CG     C N N 83  
ASN OD1    O N N 84  
ASN ND2    N N N 85  
ASN OXT    O N N 86  
ASN H      H N N 87  
ASN H2     H N N 88  
ASN HA     H N N 89  
ASN HB2    H N N 90  
ASN HB3    H N N 91  
ASN HD21   H N N 92  
ASN HD22   H N N 93  
ASN HXT    H N N 94  
ASP N      N N N 95  
ASP CA     C N S 96  
ASP C      C N N 97  
ASP O      O N N 98  
ASP CB     C N N 99  
ASP CG     C N N 100 
ASP OD1    O N N 101 
ASP OD2    O N N 102 
ASP OXT    O N N 103 
ASP H      H N N 104 
ASP H2     H N N 105 
ASP HA     H N N 106 
ASP HB2    H N N 107 
ASP HB3    H N N 108 
ASP HD2    H N N 109 
ASP HXT    H N N 110 
C   OP3    O N N 111 
C   P      P N N 112 
C   OP1    O N N 113 
C   OP2    O N N 114 
C   "O5'"  O N N 115 
C   "C5'"  C N N 116 
C   "C4'"  C N R 117 
C   "O4'"  O N N 118 
C   "C3'"  C N S 119 
C   "O3'"  O N N 120 
C   "C2'"  C N R 121 
C   "O2'"  O N N 122 
C   "C1'"  C N R 123 
C   N1     N N N 124 
C   C2     C N N 125 
C   O2     O N N 126 
C   N3     N N N 127 
C   C4     C N N 128 
C   N4     N N N 129 
C   C5     C N N 130 
C   C6     C N N 131 
C   HOP3   H N N 132 
C   HOP2   H N N 133 
C   "H5'"  H N N 134 
C   "H5''" H N N 135 
C   "H4'"  H N N 136 
C   "H3'"  H N N 137 
C   "HO3'" H N N 138 
C   "H2'"  H N N 139 
C   "HO2'" H N N 140 
C   "H1'"  H N N 141 
C   H41    H N N 142 
C   H42    H N N 143 
C   H5     H N N 144 
C   H6     H N N 145 
CYS N      N N N 146 
CYS CA     C N R 147 
CYS C      C N N 148 
CYS O      O N N 149 
CYS CB     C N N 150 
CYS SG     S N N 151 
CYS OXT    O N N 152 
CYS H      H N N 153 
CYS H2     H N N 154 
CYS HA     H N N 155 
CYS HB2    H N N 156 
CYS HB3    H N N 157 
CYS HG     H N N 158 
CYS HXT    H N N 159 
DA  OP3    O N N 160 
DA  P      P N N 161 
DA  OP1    O N N 162 
DA  OP2    O N N 163 
DA  "O5'"  O N N 164 
DA  "C5'"  C N N 165 
DA  "C4'"  C N R 166 
DA  "O4'"  O N N 167 
DA  "C3'"  C N S 168 
DA  "O3'"  O N N 169 
DA  "C2'"  C N N 170 
DA  "C1'"  C N R 171 
DA  N9     N Y N 172 
DA  C8     C Y N 173 
DA  N7     N Y N 174 
DA  C5     C Y N 175 
DA  C6     C Y N 176 
DA  N6     N N N 177 
DA  N1     N Y N 178 
DA  C2     C Y N 179 
DA  N3     N Y N 180 
DA  C4     C Y N 181 
DA  HOP3   H N N 182 
DA  HOP2   H N N 183 
DA  "H5'"  H N N 184 
DA  "H5''" H N N 185 
DA  "H4'"  H N N 186 
DA  "H3'"  H N N 187 
DA  "HO3'" H N N 188 
DA  "H2'"  H N N 189 
DA  "H2''" H N N 190 
DA  "H1'"  H N N 191 
DA  H8     H N N 192 
DA  H61    H N N 193 
DA  H62    H N N 194 
DA  H2     H N N 195 
DC  OP3    O N N 196 
DC  P      P N N 197 
DC  OP1    O N N 198 
DC  OP2    O N N 199 
DC  "O5'"  O N N 200 
DC  "C5'"  C N N 201 
DC  "C4'"  C N R 202 
DC  "O4'"  O N N 203 
DC  "C3'"  C N S 204 
DC  "O3'"  O N N 205 
DC  "C2'"  C N N 206 
DC  "C1'"  C N R 207 
DC  N1     N N N 208 
DC  C2     C N N 209 
DC  O2     O N N 210 
DC  N3     N N N 211 
DC  C4     C N N 212 
DC  N4     N N N 213 
DC  C5     C N N 214 
DC  C6     C N N 215 
DC  HOP3   H N N 216 
DC  HOP2   H N N 217 
DC  "H5'"  H N N 218 
DC  "H5''" H N N 219 
DC  "H4'"  H N N 220 
DC  "H3'"  H N N 221 
DC  "HO3'" H N N 222 
DC  "H2'"  H N N 223 
DC  "H2''" H N N 224 
DC  "H1'"  H N N 225 
DC  H41    H N N 226 
DC  H42    H N N 227 
DC  H5     H N N 228 
DC  H6     H N N 229 
DG  OP3    O N N 230 
DG  P      P N N 231 
DG  OP1    O N N 232 
DG  OP2    O N N 233 
DG  "O5'"  O N N 234 
DG  "C5'"  C N N 235 
DG  "C4'"  C N R 236 
DG  "O4'"  O N N 237 
DG  "C3'"  C N S 238 
DG  "O3'"  O N N 239 
DG  "C2'"  C N N 240 
DG  "C1'"  C N R 241 
DG  N9     N Y N 242 
DG  C8     C Y N 243 
DG  N7     N Y N 244 
DG  C5     C Y N 245 
DG  C6     C N N 246 
DG  O6     O N N 247 
DG  N1     N N N 248 
DG  C2     C N N 249 
DG  N2     N N N 250 
DG  N3     N N N 251 
DG  C4     C Y N 252 
DG  HOP3   H N N 253 
DG  HOP2   H N N 254 
DG  "H5'"  H N N 255 
DG  "H5''" H N N 256 
DG  "H4'"  H N N 257 
DG  "H3'"  H N N 258 
DG  "HO3'" H N N 259 
DG  "H2'"  H N N 260 
DG  "H2''" H N N 261 
DG  "H1'"  H N N 262 
DG  H8     H N N 263 
DG  H1     H N N 264 
DG  H21    H N N 265 
DG  H22    H N N 266 
DT  OP3    O N N 267 
DT  P      P N N 268 
DT  OP1    O N N 269 
DT  OP2    O N N 270 
DT  "O5'"  O N N 271 
DT  "C5'"  C N N 272 
DT  "C4'"  C N R 273 
DT  "O4'"  O N N 274 
DT  "C3'"  C N S 275 
DT  "O3'"  O N N 276 
DT  "C2'"  C N N 277 
DT  "C1'"  C N R 278 
DT  N1     N N N 279 
DT  C2     C N N 280 
DT  O2     O N N 281 
DT  N3     N N N 282 
DT  C4     C N N 283 
DT  O4     O N N 284 
DT  C5     C N N 285 
DT  C7     C N N 286 
DT  C6     C N N 287 
DT  HOP3   H N N 288 
DT  HOP2   H N N 289 
DT  "H5'"  H N N 290 
DT  "H5''" H N N 291 
DT  "H4'"  H N N 292 
DT  "H3'"  H N N 293 
DT  "HO3'" H N N 294 
DT  "H2'"  H N N 295 
DT  "H2''" H N N 296 
DT  "H1'"  H N N 297 
DT  H3     H N N 298 
DT  H71    H N N 299 
DT  H72    H N N 300 
DT  H73    H N N 301 
DT  H6     H N N 302 
G   OP3    O N N 303 
G   P      P N N 304 
G   OP1    O N N 305 
G   OP2    O N N 306 
G   "O5'"  O N N 307 
G   "C5'"  C N N 308 
G   "C4'"  C N R 309 
G   "O4'"  O N N 310 
G   "C3'"  C N S 311 
G   "O3'"  O N N 312 
G   "C2'"  C N R 313 
G   "O2'"  O N N 314 
G   "C1'"  C N R 315 
G   N9     N Y N 316 
G   C8     C Y N 317 
G   N7     N Y N 318 
G   C5     C Y N 319 
G   C6     C N N 320 
G   O6     O N N 321 
G   N1     N N N 322 
G   C2     C N N 323 
G   N2     N N N 324 
G   N3     N N N 325 
G   C4     C Y N 326 
G   HOP3   H N N 327 
G   HOP2   H N N 328 
G   "H5'"  H N N 329 
G   "H5''" H N N 330 
G   "H4'"  H N N 331 
G   "H3'"  H N N 332 
G   "HO3'" H N N 333 
G   "H2'"  H N N 334 
G   "HO2'" H N N 335 
G   "H1'"  H N N 336 
G   H8     H N N 337 
G   H1     H N N 338 
G   H21    H N N 339 
G   H22    H N N 340 
GLN N      N N N 341 
GLN CA     C N S 342 
GLN C      C N N 343 
GLN O      O N N 344 
GLN CB     C N N 345 
GLN CG     C N N 346 
GLN CD     C N N 347 
GLN OE1    O N N 348 
GLN NE2    N N N 349 
GLN OXT    O N N 350 
GLN H      H N N 351 
GLN H2     H N N 352 
GLN HA     H N N 353 
GLN HB2    H N N 354 
GLN HB3    H N N 355 
GLN HG2    H N N 356 
GLN HG3    H N N 357 
GLN HE21   H N N 358 
GLN HE22   H N N 359 
GLN HXT    H N N 360 
GLU N      N N N 361 
GLU CA     C N S 362 
GLU C      C N N 363 
GLU O      O N N 364 
GLU CB     C N N 365 
GLU CG     C N N 366 
GLU CD     C N N 367 
GLU OE1    O N N 368 
GLU OE2    O N N 369 
GLU OXT    O N N 370 
GLU H      H N N 371 
GLU H2     H N N 372 
GLU HA     H N N 373 
GLU HB2    H N N 374 
GLU HB3    H N N 375 
GLU HG2    H N N 376 
GLU HG3    H N N 377 
GLU HE2    H N N 378 
GLU HXT    H N N 379 
GLY N      N N N 380 
GLY CA     C N N 381 
GLY C      C N N 382 
GLY O      O N N 383 
GLY OXT    O N N 384 
GLY H      H N N 385 
GLY H2     H N N 386 
GLY HA2    H N N 387 
GLY HA3    H N N 388 
GLY HXT    H N N 389 
HIS N      N N N 390 
HIS CA     C N S 391 
HIS C      C N N 392 
HIS O      O N N 393 
HIS CB     C N N 394 
HIS CG     C Y N 395 
HIS ND1    N Y N 396 
HIS CD2    C Y N 397 
HIS CE1    C Y N 398 
HIS NE2    N Y N 399 
HIS OXT    O N N 400 
HIS H      H N N 401 
HIS H2     H N N 402 
HIS HA     H N N 403 
HIS HB2    H N N 404 
HIS HB3    H N N 405 
HIS HD1    H N N 406 
HIS HD2    H N N 407 
HIS HE1    H N N 408 
HIS HE2    H N N 409 
HIS HXT    H N N 410 
ILE N      N N N 411 
ILE CA     C N S 412 
ILE C      C N N 413 
ILE O      O N N 414 
ILE CB     C N S 415 
ILE CG1    C N N 416 
ILE CG2    C N N 417 
ILE CD1    C N N 418 
ILE OXT    O N N 419 
ILE H      H N N 420 
ILE H2     H N N 421 
ILE HA     H N N 422 
ILE HB     H N N 423 
ILE HG12   H N N 424 
ILE HG13   H N N 425 
ILE HG21   H N N 426 
ILE HG22   H N N 427 
ILE HG23   H N N 428 
ILE HD11   H N N 429 
ILE HD12   H N N 430 
ILE HD13   H N N 431 
ILE HXT    H N N 432 
LEU N      N N N 433 
LEU CA     C N S 434 
LEU C      C N N 435 
LEU O      O N N 436 
LEU CB     C N N 437 
LEU CG     C N N 438 
LEU CD1    C N N 439 
LEU CD2    C N N 440 
LEU OXT    O N N 441 
LEU H      H N N 442 
LEU H2     H N N 443 
LEU HA     H N N 444 
LEU HB2    H N N 445 
LEU HB3    H N N 446 
LEU HG     H N N 447 
LEU HD11   H N N 448 
LEU HD12   H N N 449 
LEU HD13   H N N 450 
LEU HD21   H N N 451 
LEU HD22   H N N 452 
LEU HD23   H N N 453 
LEU HXT    H N N 454 
LYS N      N N N 455 
LYS CA     C N S 456 
LYS C      C N N 457 
LYS O      O N N 458 
LYS CB     C N N 459 
LYS CG     C N N 460 
LYS CD     C N N 461 
LYS CE     C N N 462 
LYS NZ     N N N 463 
LYS OXT    O N N 464 
LYS H      H N N 465 
LYS H2     H N N 466 
LYS HA     H N N 467 
LYS HB2    H N N 468 
LYS HB3    H N N 469 
LYS HG2    H N N 470 
LYS HG3    H N N 471 
LYS HD2    H N N 472 
LYS HD3    H N N 473 
LYS HE2    H N N 474 
LYS HE3    H N N 475 
LYS HZ1    H N N 476 
LYS HZ2    H N N 477 
LYS HZ3    H N N 478 
LYS HXT    H N N 479 
MET N      N N N 480 
MET CA     C N S 481 
MET C      C N N 482 
MET O      O N N 483 
MET CB     C N N 484 
MET CG     C N N 485 
MET SD     S N N 486 
MET CE     C N N 487 
MET OXT    O N N 488 
MET H      H N N 489 
MET H2     H N N 490 
MET HA     H N N 491 
MET HB2    H N N 492 
MET HB3    H N N 493 
MET HG2    H N N 494 
MET HG3    H N N 495 
MET HE1    H N N 496 
MET HE2    H N N 497 
MET HE3    H N N 498 
MET HXT    H N N 499 
PHE N      N N N 500 
PHE CA     C N S 501 
PHE C      C N N 502 
PHE O      O N N 503 
PHE CB     C N N 504 
PHE CG     C Y N 505 
PHE CD1    C Y N 506 
PHE CD2    C Y N 507 
PHE CE1    C Y N 508 
PHE CE2    C Y N 509 
PHE CZ     C Y N 510 
PHE OXT    O N N 511 
PHE H      H N N 512 
PHE H2     H N N 513 
PHE HA     H N N 514 
PHE HB2    H N N 515 
PHE HB3    H N N 516 
PHE HD1    H N N 517 
PHE HD2    H N N 518 
PHE HE1    H N N 519 
PHE HE2    H N N 520 
PHE HZ     H N N 521 
PHE HXT    H N N 522 
PRO N      N N N 523 
PRO CA     C N S 524 
PRO C      C N N 525 
PRO O      O N N 526 
PRO CB     C N N 527 
PRO CG     C N N 528 
PRO CD     C N N 529 
PRO OXT    O N N 530 
PRO H      H N N 531 
PRO HA     H N N 532 
PRO HB2    H N N 533 
PRO HB3    H N N 534 
PRO HG2    H N N 535 
PRO HG3    H N N 536 
PRO HD2    H N N 537 
PRO HD3    H N N 538 
PRO HXT    H N N 539 
SER N      N N N 540 
SER CA     C N S 541 
SER C      C N N 542 
SER O      O N N 543 
SER CB     C N N 544 
SER OG     O N N 545 
SER OXT    O N N 546 
SER H      H N N 547 
SER H2     H N N 548 
SER HA     H N N 549 
SER HB2    H N N 550 
SER HB3    H N N 551 
SER HG     H N N 552 
SER HXT    H N N 553 
THR N      N N N 554 
THR CA     C N S 555 
THR C      C N N 556 
THR O      O N N 557 
THR CB     C N R 558 
THR OG1    O N N 559 
THR CG2    C N N 560 
THR OXT    O N N 561 
THR H      H N N 562 
THR H2     H N N 563 
THR HA     H N N 564 
THR HB     H N N 565 
THR HG1    H N N 566 
THR HG21   H N N 567 
THR HG22   H N N 568 
THR HG23   H N N 569 
THR HXT    H N N 570 
TRP N      N N N 571 
TRP CA     C N S 572 
TRP C      C N N 573 
TRP O      O N N 574 
TRP CB     C N N 575 
TRP CG     C Y N 576 
TRP CD1    C Y N 577 
TRP CD2    C Y N 578 
TRP NE1    N Y N 579 
TRP CE2    C Y N 580 
TRP CE3    C Y N 581 
TRP CZ2    C Y N 582 
TRP CZ3    C Y N 583 
TRP CH2    C Y N 584 
TRP OXT    O N N 585 
TRP H      H N N 586 
TRP H2     H N N 587 
TRP HA     H N N 588 
TRP HB2    H N N 589 
TRP HB3    H N N 590 
TRP HD1    H N N 591 
TRP HE1    H N N 592 
TRP HE3    H N N 593 
TRP HZ2    H N N 594 
TRP HZ3    H N N 595 
TRP HH2    H N N 596 
TRP HXT    H N N 597 
TYR N      N N N 598 
TYR CA     C N S 599 
TYR C      C N N 600 
TYR O      O N N 601 
TYR CB     C N N 602 
TYR CG     C Y N 603 
TYR CD1    C Y N 604 
TYR CD2    C Y N 605 
TYR CE1    C Y N 606 
TYR CE2    C Y N 607 
TYR CZ     C Y N 608 
TYR OH     O N N 609 
TYR OXT    O N N 610 
TYR H      H N N 611 
TYR H2     H N N 612 
TYR HA     H N N 613 
TYR HB2    H N N 614 
TYR HB3    H N N 615 
TYR HD1    H N N 616 
TYR HD2    H N N 617 
TYR HE1    H N N 618 
TYR HE2    H N N 619 
TYR HH     H N N 620 
TYR HXT    H N N 621 
U   OP3    O N N 622 
U   P      P N N 623 
U   OP1    O N N 624 
U   OP2    O N N 625 
U   "O5'"  O N N 626 
U   "C5'"  C N N 627 
U   "C4'"  C N R 628 
U   "O4'"  O N N 629 
U   "C3'"  C N S 630 
U   "O3'"  O N N 631 
U   "C2'"  C N R 632 
U   "O2'"  O N N 633 
U   "C1'"  C N R 634 
U   N1     N N N 635 
U   C2     C N N 636 
U   O2     O N N 637 
U   N3     N N N 638 
U   C4     C N N 639 
U   O4     O N N 640 
U   C5     C N N 641 
U   C6     C N N 642 
U   HOP3   H N N 643 
U   HOP2   H N N 644 
U   "H5'"  H N N 645 
U   "H5''" H N N 646 
U   "H4'"  H N N 647 
U   "H3'"  H N N 648 
U   "HO3'" H N N 649 
U   "H2'"  H N N 650 
U   "HO2'" H N N 651 
U   "H1'"  H N N 652 
U   H3     H N N 653 
U   H5     H N N 654 
U   H6     H N N 655 
VAL N      N N N 656 
VAL CA     C N S 657 
VAL C      C N N 658 
VAL O      O N N 659 
VAL CB     C N N 660 
VAL CG1    C N N 661 
VAL CG2    C N N 662 
VAL OXT    O N N 663 
VAL H      H N N 664 
VAL H2     H N N 665 
VAL HA     H N N 666 
VAL HB     H N N 667 
VAL HG11   H N N 668 
VAL HG12   H N N 669 
VAL HG13   H N N 670 
VAL HG21   H N N 671 
VAL HG22   H N N 672 
VAL HG23   H N N 673 
VAL HXT    H N N 674 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A   OP3   P      sing N N 1   
A   OP3   HOP3   sing N N 2   
A   P     OP1    doub N N 3   
A   P     OP2    sing N N 4   
A   P     "O5'"  sing N N 5   
A   OP2   HOP2   sing N N 6   
A   "O5'" "C5'"  sing N N 7   
A   "C5'" "C4'"  sing N N 8   
A   "C5'" "H5'"  sing N N 9   
A   "C5'" "H5''" sing N N 10  
A   "C4'" "O4'"  sing N N 11  
A   "C4'" "C3'"  sing N N 12  
A   "C4'" "H4'"  sing N N 13  
A   "O4'" "C1'"  sing N N 14  
A   "C3'" "O3'"  sing N N 15  
A   "C3'" "C2'"  sing N N 16  
A   "C3'" "H3'"  sing N N 17  
A   "O3'" "HO3'" sing N N 18  
A   "C2'" "O2'"  sing N N 19  
A   "C2'" "C1'"  sing N N 20  
A   "C2'" "H2'"  sing N N 21  
A   "O2'" "HO2'" sing N N 22  
A   "C1'" N9     sing N N 23  
A   "C1'" "H1'"  sing N N 24  
A   N9    C8     sing Y N 25  
A   N9    C4     sing Y N 26  
A   C8    N7     doub Y N 27  
A   C8    H8     sing N N 28  
A   N7    C5     sing Y N 29  
A   C5    C6     sing Y N 30  
A   C5    C4     doub Y N 31  
A   C6    N6     sing N N 32  
A   C6    N1     doub Y N 33  
A   N6    H61    sing N N 34  
A   N6    H62    sing N N 35  
A   N1    C2     sing Y N 36  
A   C2    N3     doub Y N 37  
A   C2    H2     sing N N 38  
A   N3    C4     sing Y N 39  
ALA N     CA     sing N N 40  
ALA N     H      sing N N 41  
ALA N     H2     sing N N 42  
ALA CA    C      sing N N 43  
ALA CA    CB     sing N N 44  
ALA CA    HA     sing N N 45  
ALA C     O      doub N N 46  
ALA C     OXT    sing N N 47  
ALA CB    HB1    sing N N 48  
ALA CB    HB2    sing N N 49  
ALA CB    HB3    sing N N 50  
ALA OXT   HXT    sing N N 51  
ARG N     CA     sing N N 52  
ARG N     H      sing N N 53  
ARG N     H2     sing N N 54  
ARG CA    C      sing N N 55  
ARG CA    CB     sing N N 56  
ARG CA    HA     sing N N 57  
ARG C     O      doub N N 58  
ARG C     OXT    sing N N 59  
ARG CB    CG     sing N N 60  
ARG CB    HB2    sing N N 61  
ARG CB    HB3    sing N N 62  
ARG CG    CD     sing N N 63  
ARG CG    HG2    sing N N 64  
ARG CG    HG3    sing N N 65  
ARG CD    NE     sing N N 66  
ARG CD    HD2    sing N N 67  
ARG CD    HD3    sing N N 68  
ARG NE    CZ     sing N N 69  
ARG NE    HE     sing N N 70  
ARG CZ    NH1    sing N N 71  
ARG CZ    NH2    doub N N 72  
ARG NH1   HH11   sing N N 73  
ARG NH1   HH12   sing N N 74  
ARG NH2   HH21   sing N N 75  
ARG NH2   HH22   sing N N 76  
ARG OXT   HXT    sing N N 77  
ASN N     CA     sing N N 78  
ASN N     H      sing N N 79  
ASN N     H2     sing N N 80  
ASN CA    C      sing N N 81  
ASN CA    CB     sing N N 82  
ASN CA    HA     sing N N 83  
ASN C     O      doub N N 84  
ASN C     OXT    sing N N 85  
ASN CB    CG     sing N N 86  
ASN CB    HB2    sing N N 87  
ASN CB    HB3    sing N N 88  
ASN CG    OD1    doub N N 89  
ASN CG    ND2    sing N N 90  
ASN ND2   HD21   sing N N 91  
ASN ND2   HD22   sing N N 92  
ASN OXT   HXT    sing N N 93  
ASP N     CA     sing N N 94  
ASP N     H      sing N N 95  
ASP N     H2     sing N N 96  
ASP CA    C      sing N N 97  
ASP CA    CB     sing N N 98  
ASP CA    HA     sing N N 99  
ASP C     O      doub N N 100 
ASP C     OXT    sing N N 101 
ASP CB    CG     sing N N 102 
ASP CB    HB2    sing N N 103 
ASP CB    HB3    sing N N 104 
ASP CG    OD1    doub N N 105 
ASP CG    OD2    sing N N 106 
ASP OD2   HD2    sing N N 107 
ASP OXT   HXT    sing N N 108 
C   OP3   P      sing N N 109 
C   OP3   HOP3   sing N N 110 
C   P     OP1    doub N N 111 
C   P     OP2    sing N N 112 
C   P     "O5'"  sing N N 113 
C   OP2   HOP2   sing N N 114 
C   "O5'" "C5'"  sing N N 115 
C   "C5'" "C4'"  sing N N 116 
C   "C5'" "H5'"  sing N N 117 
C   "C5'" "H5''" sing N N 118 
C   "C4'" "O4'"  sing N N 119 
C   "C4'" "C3'"  sing N N 120 
C   "C4'" "H4'"  sing N N 121 
C   "O4'" "C1'"  sing N N 122 
C   "C3'" "O3'"  sing N N 123 
C   "C3'" "C2'"  sing N N 124 
C   "C3'" "H3'"  sing N N 125 
C   "O3'" "HO3'" sing N N 126 
C   "C2'" "O2'"  sing N N 127 
C   "C2'" "C1'"  sing N N 128 
C   "C2'" "H2'"  sing N N 129 
C   "O2'" "HO2'" sing N N 130 
C   "C1'" N1     sing N N 131 
C   "C1'" "H1'"  sing N N 132 
C   N1    C2     sing N N 133 
C   N1    C6     sing N N 134 
C   C2    O2     doub N N 135 
C   C2    N3     sing N N 136 
C   N3    C4     doub N N 137 
C   C4    N4     sing N N 138 
C   C4    C5     sing N N 139 
C   N4    H41    sing N N 140 
C   N4    H42    sing N N 141 
C   C5    C6     doub N N 142 
C   C5    H5     sing N N 143 
C   C6    H6     sing N N 144 
CYS N     CA     sing N N 145 
CYS N     H      sing N N 146 
CYS N     H2     sing N N 147 
CYS CA    C      sing N N 148 
CYS CA    CB     sing N N 149 
CYS CA    HA     sing N N 150 
CYS C     O      doub N N 151 
CYS C     OXT    sing N N 152 
CYS CB    SG     sing N N 153 
CYS CB    HB2    sing N N 154 
CYS CB    HB3    sing N N 155 
CYS SG    HG     sing N N 156 
CYS OXT   HXT    sing N N 157 
DA  OP3   P      sing N N 158 
DA  OP3   HOP3   sing N N 159 
DA  P     OP1    doub N N 160 
DA  P     OP2    sing N N 161 
DA  P     "O5'"  sing N N 162 
DA  OP2   HOP2   sing N N 163 
DA  "O5'" "C5'"  sing N N 164 
DA  "C5'" "C4'"  sing N N 165 
DA  "C5'" "H5'"  sing N N 166 
DA  "C5'" "H5''" sing N N 167 
DA  "C4'" "O4'"  sing N N 168 
DA  "C4'" "C3'"  sing N N 169 
DA  "C4'" "H4'"  sing N N 170 
DA  "O4'" "C1'"  sing N N 171 
DA  "C3'" "O3'"  sing N N 172 
DA  "C3'" "C2'"  sing N N 173 
DA  "C3'" "H3'"  sing N N 174 
DA  "O3'" "HO3'" sing N N 175 
DA  "C2'" "C1'"  sing N N 176 
DA  "C2'" "H2'"  sing N N 177 
DA  "C2'" "H2''" sing N N 178 
DA  "C1'" N9     sing N N 179 
DA  "C1'" "H1'"  sing N N 180 
DA  N9    C8     sing Y N 181 
DA  N9    C4     sing Y N 182 
DA  C8    N7     doub Y N 183 
DA  C8    H8     sing N N 184 
DA  N7    C5     sing Y N 185 
DA  C5    C6     sing Y N 186 
DA  C5    C4     doub Y N 187 
DA  C6    N6     sing N N 188 
DA  C6    N1     doub Y N 189 
DA  N6    H61    sing N N 190 
DA  N6    H62    sing N N 191 
DA  N1    C2     sing Y N 192 
DA  C2    N3     doub Y N 193 
DA  C2    H2     sing N N 194 
DA  N3    C4     sing Y N 195 
DC  OP3   P      sing N N 196 
DC  OP3   HOP3   sing N N 197 
DC  P     OP1    doub N N 198 
DC  P     OP2    sing N N 199 
DC  P     "O5'"  sing N N 200 
DC  OP2   HOP2   sing N N 201 
DC  "O5'" "C5'"  sing N N 202 
DC  "C5'" "C4'"  sing N N 203 
DC  "C5'" "H5'"  sing N N 204 
DC  "C5'" "H5''" sing N N 205 
DC  "C4'" "O4'"  sing N N 206 
DC  "C4'" "C3'"  sing N N 207 
DC  "C4'" "H4'"  sing N N 208 
DC  "O4'" "C1'"  sing N N 209 
DC  "C3'" "O3'"  sing N N 210 
DC  "C3'" "C2'"  sing N N 211 
DC  "C3'" "H3'"  sing N N 212 
DC  "O3'" "HO3'" sing N N 213 
DC  "C2'" "C1'"  sing N N 214 
DC  "C2'" "H2'"  sing N N 215 
DC  "C2'" "H2''" sing N N 216 
DC  "C1'" N1     sing N N 217 
DC  "C1'" "H1'"  sing N N 218 
DC  N1    C2     sing N N 219 
DC  N1    C6     sing N N 220 
DC  C2    O2     doub N N 221 
DC  C2    N3     sing N N 222 
DC  N3    C4     doub N N 223 
DC  C4    N4     sing N N 224 
DC  C4    C5     sing N N 225 
DC  N4    H41    sing N N 226 
DC  N4    H42    sing N N 227 
DC  C5    C6     doub N N 228 
DC  C5    H5     sing N N 229 
DC  C6    H6     sing N N 230 
DG  OP3   P      sing N N 231 
DG  OP3   HOP3   sing N N 232 
DG  P     OP1    doub N N 233 
DG  P     OP2    sing N N 234 
DG  P     "O5'"  sing N N 235 
DG  OP2   HOP2   sing N N 236 
DG  "O5'" "C5'"  sing N N 237 
DG  "C5'" "C4'"  sing N N 238 
DG  "C5'" "H5'"  sing N N 239 
DG  "C5'" "H5''" sing N N 240 
DG  "C4'" "O4'"  sing N N 241 
DG  "C4'" "C3'"  sing N N 242 
DG  "C4'" "H4'"  sing N N 243 
DG  "O4'" "C1'"  sing N N 244 
DG  "C3'" "O3'"  sing N N 245 
DG  "C3'" "C2'"  sing N N 246 
DG  "C3'" "H3'"  sing N N 247 
DG  "O3'" "HO3'" sing N N 248 
DG  "C2'" "C1'"  sing N N 249 
DG  "C2'" "H2'"  sing N N 250 
DG  "C2'" "H2''" sing N N 251 
DG  "C1'" N9     sing N N 252 
DG  "C1'" "H1'"  sing N N 253 
DG  N9    C8     sing Y N 254 
DG  N9    C4     sing Y N 255 
DG  C8    N7     doub Y N 256 
DG  C8    H8     sing N N 257 
DG  N7    C5     sing Y N 258 
DG  C5    C6     sing N N 259 
DG  C5    C4     doub Y N 260 
DG  C6    O6     doub N N 261 
DG  C6    N1     sing N N 262 
DG  N1    C2     sing N N 263 
DG  N1    H1     sing N N 264 
DG  C2    N2     sing N N 265 
DG  C2    N3     doub N N 266 
DG  N2    H21    sing N N 267 
DG  N2    H22    sing N N 268 
DG  N3    C4     sing N N 269 
DT  OP3   P      sing N N 270 
DT  OP3   HOP3   sing N N 271 
DT  P     OP1    doub N N 272 
DT  P     OP2    sing N N 273 
DT  P     "O5'"  sing N N 274 
DT  OP2   HOP2   sing N N 275 
DT  "O5'" "C5'"  sing N N 276 
DT  "C5'" "C4'"  sing N N 277 
DT  "C5'" "H5'"  sing N N 278 
DT  "C5'" "H5''" sing N N 279 
DT  "C4'" "O4'"  sing N N 280 
DT  "C4'" "C3'"  sing N N 281 
DT  "C4'" "H4'"  sing N N 282 
DT  "O4'" "C1'"  sing N N 283 
DT  "C3'" "O3'"  sing N N 284 
DT  "C3'" "C2'"  sing N N 285 
DT  "C3'" "H3'"  sing N N 286 
DT  "O3'" "HO3'" sing N N 287 
DT  "C2'" "C1'"  sing N N 288 
DT  "C2'" "H2'"  sing N N 289 
DT  "C2'" "H2''" sing N N 290 
DT  "C1'" N1     sing N N 291 
DT  "C1'" "H1'"  sing N N 292 
DT  N1    C2     sing N N 293 
DT  N1    C6     sing N N 294 
DT  C2    O2     doub N N 295 
DT  C2    N3     sing N N 296 
DT  N3    C4     sing N N 297 
DT  N3    H3     sing N N 298 
DT  C4    O4     doub N N 299 
DT  C4    C5     sing N N 300 
DT  C5    C7     sing N N 301 
DT  C5    C6     doub N N 302 
DT  C7    H71    sing N N 303 
DT  C7    H72    sing N N 304 
DT  C7    H73    sing N N 305 
DT  C6    H6     sing N N 306 
G   OP3   P      sing N N 307 
G   OP3   HOP3   sing N N 308 
G   P     OP1    doub N N 309 
G   P     OP2    sing N N 310 
G   P     "O5'"  sing N N 311 
G   OP2   HOP2   sing N N 312 
G   "O5'" "C5'"  sing N N 313 
G   "C5'" "C4'"  sing N N 314 
G   "C5'" "H5'"  sing N N 315 
G   "C5'" "H5''" sing N N 316 
G   "C4'" "O4'"  sing N N 317 
G   "C4'" "C3'"  sing N N 318 
G   "C4'" "H4'"  sing N N 319 
G   "O4'" "C1'"  sing N N 320 
G   "C3'" "O3'"  sing N N 321 
G   "C3'" "C2'"  sing N N 322 
G   "C3'" "H3'"  sing N N 323 
G   "O3'" "HO3'" sing N N 324 
G   "C2'" "O2'"  sing N N 325 
G   "C2'" "C1'"  sing N N 326 
G   "C2'" "H2'"  sing N N 327 
G   "O2'" "HO2'" sing N N 328 
G   "C1'" N9     sing N N 329 
G   "C1'" "H1'"  sing N N 330 
G   N9    C8     sing Y N 331 
G   N9    C4     sing Y N 332 
G   C8    N7     doub Y N 333 
G   C8    H8     sing N N 334 
G   N7    C5     sing Y N 335 
G   C5    C6     sing N N 336 
G   C5    C4     doub Y N 337 
G   C6    O6     doub N N 338 
G   C6    N1     sing N N 339 
G   N1    C2     sing N N 340 
G   N1    H1     sing N N 341 
G   C2    N2     sing N N 342 
G   C2    N3     doub N N 343 
G   N2    H21    sing N N 344 
G   N2    H22    sing N N 345 
G   N3    C4     sing N N 346 
GLN N     CA     sing N N 347 
GLN N     H      sing N N 348 
GLN N     H2     sing N N 349 
GLN CA    C      sing N N 350 
GLN CA    CB     sing N N 351 
GLN CA    HA     sing N N 352 
GLN C     O      doub N N 353 
GLN C     OXT    sing N N 354 
GLN CB    CG     sing N N 355 
GLN CB    HB2    sing N N 356 
GLN CB    HB3    sing N N 357 
GLN CG    CD     sing N N 358 
GLN CG    HG2    sing N N 359 
GLN CG    HG3    sing N N 360 
GLN CD    OE1    doub N N 361 
GLN CD    NE2    sing N N 362 
GLN NE2   HE21   sing N N 363 
GLN NE2   HE22   sing N N 364 
GLN OXT   HXT    sing N N 365 
GLU N     CA     sing N N 366 
GLU N     H      sing N N 367 
GLU N     H2     sing N N 368 
GLU CA    C      sing N N 369 
GLU CA    CB     sing N N 370 
GLU CA    HA     sing N N 371 
GLU C     O      doub N N 372 
GLU C     OXT    sing N N 373 
GLU CB    CG     sing N N 374 
GLU CB    HB2    sing N N 375 
GLU CB    HB3    sing N N 376 
GLU CG    CD     sing N N 377 
GLU CG    HG2    sing N N 378 
GLU CG    HG3    sing N N 379 
GLU CD    OE1    doub N N 380 
GLU CD    OE2    sing N N 381 
GLU OE2   HE2    sing N N 382 
GLU OXT   HXT    sing N N 383 
GLY N     CA     sing N N 384 
GLY N     H      sing N N 385 
GLY N     H2     sing N N 386 
GLY CA    C      sing N N 387 
GLY CA    HA2    sing N N 388 
GLY CA    HA3    sing N N 389 
GLY C     O      doub N N 390 
GLY C     OXT    sing N N 391 
GLY OXT   HXT    sing N N 392 
HIS N     CA     sing N N 393 
HIS N     H      sing N N 394 
HIS N     H2     sing N N 395 
HIS CA    C      sing N N 396 
HIS CA    CB     sing N N 397 
HIS CA    HA     sing N N 398 
HIS C     O      doub N N 399 
HIS C     OXT    sing N N 400 
HIS CB    CG     sing N N 401 
HIS CB    HB2    sing N N 402 
HIS CB    HB3    sing N N 403 
HIS CG    ND1    sing Y N 404 
HIS CG    CD2    doub Y N 405 
HIS ND1   CE1    doub Y N 406 
HIS ND1   HD1    sing N N 407 
HIS CD2   NE2    sing Y N 408 
HIS CD2   HD2    sing N N 409 
HIS CE1   NE2    sing Y N 410 
HIS CE1   HE1    sing N N 411 
HIS NE2   HE2    sing N N 412 
HIS OXT   HXT    sing N N 413 
ILE N     CA     sing N N 414 
ILE N     H      sing N N 415 
ILE N     H2     sing N N 416 
ILE CA    C      sing N N 417 
ILE CA    CB     sing N N 418 
ILE CA    HA     sing N N 419 
ILE C     O      doub N N 420 
ILE C     OXT    sing N N 421 
ILE CB    CG1    sing N N 422 
ILE CB    CG2    sing N N 423 
ILE CB    HB     sing N N 424 
ILE CG1   CD1    sing N N 425 
ILE CG1   HG12   sing N N 426 
ILE CG1   HG13   sing N N 427 
ILE CG2   HG21   sing N N 428 
ILE CG2   HG22   sing N N 429 
ILE CG2   HG23   sing N N 430 
ILE CD1   HD11   sing N N 431 
ILE CD1   HD12   sing N N 432 
ILE CD1   HD13   sing N N 433 
ILE OXT   HXT    sing N N 434 
LEU N     CA     sing N N 435 
LEU N     H      sing N N 436 
LEU N     H2     sing N N 437 
LEU CA    C      sing N N 438 
LEU CA    CB     sing N N 439 
LEU CA    HA     sing N N 440 
LEU C     O      doub N N 441 
LEU C     OXT    sing N N 442 
LEU CB    CG     sing N N 443 
LEU CB    HB2    sing N N 444 
LEU CB    HB3    sing N N 445 
LEU CG    CD1    sing N N 446 
LEU CG    CD2    sing N N 447 
LEU CG    HG     sing N N 448 
LEU CD1   HD11   sing N N 449 
LEU CD1   HD12   sing N N 450 
LEU CD1   HD13   sing N N 451 
LEU CD2   HD21   sing N N 452 
LEU CD2   HD22   sing N N 453 
LEU CD2   HD23   sing N N 454 
LEU OXT   HXT    sing N N 455 
LYS N     CA     sing N N 456 
LYS N     H      sing N N 457 
LYS N     H2     sing N N 458 
LYS CA    C      sing N N 459 
LYS CA    CB     sing N N 460 
LYS CA    HA     sing N N 461 
LYS C     O      doub N N 462 
LYS C     OXT    sing N N 463 
LYS CB    CG     sing N N 464 
LYS CB    HB2    sing N N 465 
LYS CB    HB3    sing N N 466 
LYS CG    CD     sing N N 467 
LYS CG    HG2    sing N N 468 
LYS CG    HG3    sing N N 469 
LYS CD    CE     sing N N 470 
LYS CD    HD2    sing N N 471 
LYS CD    HD3    sing N N 472 
LYS CE    NZ     sing N N 473 
LYS CE    HE2    sing N N 474 
LYS CE    HE3    sing N N 475 
LYS NZ    HZ1    sing N N 476 
LYS NZ    HZ2    sing N N 477 
LYS NZ    HZ3    sing N N 478 
LYS OXT   HXT    sing N N 479 
MET N     CA     sing N N 480 
MET N     H      sing N N 481 
MET N     H2     sing N N 482 
MET CA    C      sing N N 483 
MET CA    CB     sing N N 484 
MET CA    HA     sing N N 485 
MET C     O      doub N N 486 
MET C     OXT    sing N N 487 
MET CB    CG     sing N N 488 
MET CB    HB2    sing N N 489 
MET CB    HB3    sing N N 490 
MET CG    SD     sing N N 491 
MET CG    HG2    sing N N 492 
MET CG    HG3    sing N N 493 
MET SD    CE     sing N N 494 
MET CE    HE1    sing N N 495 
MET CE    HE2    sing N N 496 
MET CE    HE3    sing N N 497 
MET OXT   HXT    sing N N 498 
PHE N     CA     sing N N 499 
PHE N     H      sing N N 500 
PHE N     H2     sing N N 501 
PHE CA    C      sing N N 502 
PHE CA    CB     sing N N 503 
PHE CA    HA     sing N N 504 
PHE C     O      doub N N 505 
PHE C     OXT    sing N N 506 
PHE CB    CG     sing N N 507 
PHE CB    HB2    sing N N 508 
PHE CB    HB3    sing N N 509 
PHE CG    CD1    doub Y N 510 
PHE CG    CD2    sing Y N 511 
PHE CD1   CE1    sing Y N 512 
PHE CD1   HD1    sing N N 513 
PHE CD2   CE2    doub Y N 514 
PHE CD2   HD2    sing N N 515 
PHE CE1   CZ     doub Y N 516 
PHE CE1   HE1    sing N N 517 
PHE CE2   CZ     sing Y N 518 
PHE CE2   HE2    sing N N 519 
PHE CZ    HZ     sing N N 520 
PHE OXT   HXT    sing N N 521 
PRO N     CA     sing N N 522 
PRO N     CD     sing N N 523 
PRO N     H      sing N N 524 
PRO CA    C      sing N N 525 
PRO CA    CB     sing N N 526 
PRO CA    HA     sing N N 527 
PRO C     O      doub N N 528 
PRO C     OXT    sing N N 529 
PRO CB    CG     sing N N 530 
PRO CB    HB2    sing N N 531 
PRO CB    HB3    sing N N 532 
PRO CG    CD     sing N N 533 
PRO CG    HG2    sing N N 534 
PRO CG    HG3    sing N N 535 
PRO CD    HD2    sing N N 536 
PRO CD    HD3    sing N N 537 
PRO OXT   HXT    sing N N 538 
SER N     CA     sing N N 539 
SER N     H      sing N N 540 
SER N     H2     sing N N 541 
SER CA    C      sing N N 542 
SER CA    CB     sing N N 543 
SER CA    HA     sing N N 544 
SER C     O      doub N N 545 
SER C     OXT    sing N N 546 
SER CB    OG     sing N N 547 
SER CB    HB2    sing N N 548 
SER CB    HB3    sing N N 549 
SER OG    HG     sing N N 550 
SER OXT   HXT    sing N N 551 
THR N     CA     sing N N 552 
THR N     H      sing N N 553 
THR N     H2     sing N N 554 
THR CA    C      sing N N 555 
THR CA    CB     sing N N 556 
THR CA    HA     sing N N 557 
THR C     O      doub N N 558 
THR C     OXT    sing N N 559 
THR CB    OG1    sing N N 560 
THR CB    CG2    sing N N 561 
THR CB    HB     sing N N 562 
THR OG1   HG1    sing N N 563 
THR CG2   HG21   sing N N 564 
THR CG2   HG22   sing N N 565 
THR CG2   HG23   sing N N 566 
THR OXT   HXT    sing N N 567 
TRP N     CA     sing N N 568 
TRP N     H      sing N N 569 
TRP N     H2     sing N N 570 
TRP CA    C      sing N N 571 
TRP CA    CB     sing N N 572 
TRP CA    HA     sing N N 573 
TRP C     O      doub N N 574 
TRP C     OXT    sing N N 575 
TRP CB    CG     sing N N 576 
TRP CB    HB2    sing N N 577 
TRP CB    HB3    sing N N 578 
TRP CG    CD1    doub Y N 579 
TRP CG    CD2    sing Y N 580 
TRP CD1   NE1    sing Y N 581 
TRP CD1   HD1    sing N N 582 
TRP CD2   CE2    doub Y N 583 
TRP CD2   CE3    sing Y N 584 
TRP NE1   CE2    sing Y N 585 
TRP NE1   HE1    sing N N 586 
TRP CE2   CZ2    sing Y N 587 
TRP CE3   CZ3    doub Y N 588 
TRP CE3   HE3    sing N N 589 
TRP CZ2   CH2    doub Y N 590 
TRP CZ2   HZ2    sing N N 591 
TRP CZ3   CH2    sing Y N 592 
TRP CZ3   HZ3    sing N N 593 
TRP CH2   HH2    sing N N 594 
TRP OXT   HXT    sing N N 595 
TYR N     CA     sing N N 596 
TYR N     H      sing N N 597 
TYR N     H2     sing N N 598 
TYR CA    C      sing N N 599 
TYR CA    CB     sing N N 600 
TYR CA    HA     sing N N 601 
TYR C     O      doub N N 602 
TYR C     OXT    sing N N 603 
TYR CB    CG     sing N N 604 
TYR CB    HB2    sing N N 605 
TYR CB    HB3    sing N N 606 
TYR CG    CD1    doub Y N 607 
TYR CG    CD2    sing Y N 608 
TYR CD1   CE1    sing Y N 609 
TYR CD1   HD1    sing N N 610 
TYR CD2   CE2    doub Y N 611 
TYR CD2   HD2    sing N N 612 
TYR CE1   CZ     doub Y N 613 
TYR CE1   HE1    sing N N 614 
TYR CE2   CZ     sing Y N 615 
TYR CE2   HE2    sing N N 616 
TYR CZ    OH     sing N N 617 
TYR OH    HH     sing N N 618 
TYR OXT   HXT    sing N N 619 
U   OP3   P      sing N N 620 
U   OP3   HOP3   sing N N 621 
U   P     OP1    doub N N 622 
U   P     OP2    sing N N 623 
U   P     "O5'"  sing N N 624 
U   OP2   HOP2   sing N N 625 
U   "O5'" "C5'"  sing N N 626 
U   "C5'" "C4'"  sing N N 627 
U   "C5'" "H5'"  sing N N 628 
U   "C5'" "H5''" sing N N 629 
U   "C4'" "O4'"  sing N N 630 
U   "C4'" "C3'"  sing N N 631 
U   "C4'" "H4'"  sing N N 632 
U   "O4'" "C1'"  sing N N 633 
U   "C3'" "O3'"  sing N N 634 
U   "C3'" "C2'"  sing N N 635 
U   "C3'" "H3'"  sing N N 636 
U   "O3'" "HO3'" sing N N 637 
U   "C2'" "O2'"  sing N N 638 
U   "C2'" "C1'"  sing N N 639 
U   "C2'" "H2'"  sing N N 640 
U   "O2'" "HO2'" sing N N 641 
U   "C1'" N1     sing N N 642 
U   "C1'" "H1'"  sing N N 643 
U   N1    C2     sing N N 644 
U   N1    C6     sing N N 645 
U   C2    O2     doub N N 646 
U   C2    N3     sing N N 647 
U   N3    C4     sing N N 648 
U   N3    H3     sing N N 649 
U   C4    O4     doub N N 650 
U   C4    C5     sing N N 651 
U   C5    C6     doub N N 652 
U   C5    H5     sing N N 653 
U   C6    H6     sing N N 654 
VAL N     CA     sing N N 655 
VAL N     H      sing N N 656 
VAL N     H2     sing N N 657 
VAL CA    C      sing N N 658 
VAL CA    CB     sing N N 659 
VAL CA    HA     sing N N 660 
VAL C     O      doub N N 661 
VAL C     OXT    sing N N 662 
VAL CB    CG1    sing N N 663 
VAL CB    CG2    sing N N 664 
VAL CB    HB     sing N N 665 
VAL CG1   HG11   sing N N 666 
VAL CG1   HG12   sing N N 667 
VAL CG1   HG13   sing N N 668 
VAL CG2   HG21   sing N N 669 
VAL CG2   HG22   sing N N 670 
VAL CG2   HG23   sing N N 671 
VAL OXT   HXT    sing N N 672 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-06-03 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8ZQS 
_em_admin.last_update        2025-06-11 
_em_admin.map_release_date   2025-06-11 
_em_admin.title              'Cryo-EM structure of Cas12X with crRNA and Target DNA, Conformation 1' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          12908 
_em_entity_assembly_naturalsource.organism             'unclassified sequences' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          469008 
_em_entity_assembly_recombinant.organism             'Escherichia coli BL21(DE3)' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? 
MASKING                         ? 3  ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_ndb_struct_conf_na.entry_id 
_ndb_struct_conf_na.feature 
8ZQS 'double helix'        
8ZQS 'a-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 B G  1  1_555 B C  36 1_555 -0.279 -0.176 0.309  -0.583 -18.124 -0.757   1  B_G-36:C-1_B  B -36 ? B -1  ? 19 1 
1 B U  2  1_555 B A  35 1_555 -0.182 0.758  0.702  -5.861 -23.662 9.388    2  B_U-35:A-2_B  B -35 ? B -2  ? ?  ? 
1 B G  3  1_555 B C  34 1_555 -0.202 -0.142 0.217  9.617  -7.451  0.938    3  B_G-34:C-3_B  B -34 ? B -3  ? 19 1 
1 B C  4  1_555 B G  33 1_555 0.282  -0.090 -0.332 18.526 -15.272 3.047    4  B_C-33:G-4_B  B -33 ? B -4  ? 19 1 
1 B G  6  1_555 B A  29 1_555 -0.290 1.463  -0.032 12.542 8.724   -14.402  5  B_G-31:A-8_B  B -31 ? B -8  ? 8  1 
1 B C  7  1_555 B G  28 1_555 0.172  -0.133 -0.137 -1.098 -2.970  -0.853   6  B_C-30:G-9_B  B -30 ? B -9  ? 19 1 
1 B U  8  1_555 B A  27 1_555 -0.063 -0.094 0.106  -2.393 -3.965  2.908    7  B_U-29:A-10_B B -29 ? B -10 ? 20 1 
1 B G  9  1_555 B C  26 1_555 -0.156 -0.108 0.164  -2.643 5.763   -0.571   8  B_G-28:C-11_B B -28 ? B -11 ? 19 1 
1 B U  10 1_555 B G  25 1_555 2.077  -0.377 0.023  5.543  6.569   -2.364   9  B_U-27:G-12_B B -27 ? B -12 ? 28 1 
1 B C  11 1_555 B G  24 1_555 0.189  -0.171 -0.475 2.593  -3.743  0.713    10 B_C-26:G-13_B B -26 ? B -13 ? 19 1 
1 B U  12 1_555 B A  23 1_555 0.208  2.524  0.131  -0.738 -1.910  -100.729 11 B_U-25:A-14_B B -25 ? B -14 ? ?  ? 
1 B C  13 1_555 B G  22 1_555 0.183  -0.137 -0.477 2.001  -1.176  0.186    12 B_C-24:G-15_B B -24 ? B -15 ? 19 1 
1 B C  14 1_555 B G  21 1_555 0.209  -0.194 -0.636 1.671  -0.222  0.419    13 B_C-23:G-16_B B -23 ? B -16 ? 19 1 
1 B C  15 1_555 B G  20 1_555 0.173  -0.194 -0.488 0.630  12.059  -0.992   14 B_C-22:G-17_B B -22 ? B -17 ? 19 1 
1 B C  37 1_555 C DG 34 1_555 0.288  -0.169 -0.329 -5.768 -1.232  3.058    15 B_C0:DG0_C    B 0   ? C 0   ? 19 1 
1 B U  38 1_555 C DA 33 1_555 -3.246 0.065  -0.818 3.962  -0.776  -19.821  16 B_U1:DA-1_C   B 1   ? C -1  ? ?  1 
1 B C  40 1_555 C DA 32 1_555 2.020  -1.447 2.169  7.167  9.128   25.639   17 B_C3:DA-2_C   B 3   ? C -2  ? ?  1 
1 C DC 35 1_555 D DG 10 1_555 -0.132 -5.750 -1.674 19.428 6.015   67.394   18 C_DC1:DG8_D   C 1   ? D 8   ? ?  ? 
1 C DA 36 1_555 D DT 9  1_555 -0.399 -2.651 0.819  -0.003 11.352  82.962   19 C_DA2:DT7_D   C 2   ? D 7   ? ?  ? 
1 C DT 37 1_555 D DA 8  1_555 -0.084 -0.259 -0.787 -0.291 -4.385  2.405    20 C_DT3:DA6_D   C 3   ? D 6   ? 20 1 
1 C DA 38 1_555 D DT 7  1_555 0.144  -0.076 -0.263 -6.609 1.478   -1.845   21 C_DA4:DT5_D   C 4   ? D 5   ? 20 1 
1 C DT 39 1_555 D DA 6  1_555 -0.109 -0.105 0.040  0.213  2.476   -1.801   22 C_DT5:DA4_D   C 5   ? D 4   ? 20 1 
1 C DC 40 1_555 D DG 5  1_555 0.153  -0.151 0.211  2.673  3.188   -0.748   23 C_DC6:DG3_D   C 6   ? D 3   ? 19 1 
1 C DG 41 1_555 D DC 4  1_555 -0.199 -0.221 -0.749 -4.384 -2.595  0.197    24 C_DG7:DC2_D   C 7   ? D 2   ? 19 1 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 B G  1  1_555 B C  36 1_555 B U  2  1_555 B A  35 1_555 0.213  -1.295 3.578  -0.984   -2.070  34.056   -1.844 -0.536 3.641  
-3.530  1.677   34.131   1  BB_G-36U-35:A-2C-1_BB   B -36 ? B -1  ? B -35 ? B -2  ? 
1 B U  2  1_555 B A  35 1_555 B G  3  1_555 B C  34 1_555 -0.033 -1.538 2.596  -0.676   14.913  25.038   -5.251 -0.033 1.465  
31.118  1.410   29.090   2  BB_U-35G-34:C-3A-2_BB   B -35 ? B -2  ? B -34 ? B -3  ? 
1 B G  3  1_555 B C  34 1_555 B C  4  1_555 B G  33 1_555 0.633  -1.268 3.386  0.721    -2.879  38.644   -1.541 -0.862 3.479  
-4.343  -1.088  38.753   3  BB_G-34C-33:G-4C-3_BB   B -34 ? B -3  ? B -33 ? B -4  ? 
1 B G  6  1_555 B A  29 1_555 B C  7  1_555 B G  28 1_555 0.829  -2.234 3.325  1.606    7.663   41.536   -3.856 -0.991 2.915  
10.691  -2.241  42.235   4  BB_G-31C-30:G-9A-8_BB   B -31 ? B -8  ? B -30 ? B -9  ? 
1 B C  7  1_555 B G  28 1_555 B U  8  1_555 B A  27 1_555 -0.340 -1.831 3.161  -1.228   2.725   29.504   -4.119 0.420  2.995  
5.333   2.404   29.652   5  BB_C-30U-29:A-10G-9_BB  B -30 ? B -9  ? B -29 ? B -10 ? 
1 B U  8  1_555 B A  27 1_555 B G  9  1_555 B C  26 1_555 -0.130 -1.651 2.929  0.366    8.462   32.824   -3.970 0.272  2.438  
14.672  -0.634  33.870   6  BB_U-29G-28:C-11A-10_BB B -29 ? B -10 ? B -28 ? B -11 ? 
1 B G  9  1_555 B C  26 1_555 B U  10 1_555 B G  25 1_555 0.141  -1.346 3.095  1.158    4.851   38.837   -2.546 -0.082 2.915  
7.259   -1.733  39.144   7  BB_G-28U-27:G-12C-11_BB B -28 ? B -11 ? B -27 ? B -12 ? 
1 B U  10 1_555 B G  25 1_555 B C  11 1_555 B G  24 1_555 0.222  -2.174 3.126  5.786    9.773   25.442   -6.503 0.711  2.157  
20.912  -12.381 27.823   8  BB_U-27C-26:G-13G-12_BB B -27 ? B -12 ? B -26 ? B -13 ? 
1 B C  11 1_555 B G  24 1_555 B U  12 1_555 B A  23 1_555 -1.332 -2.574 3.238  -4.728   12.284  74.237   -2.463 0.955  2.913  
10.101  3.888   75.229   9  BB_C-26U-25:A-14G-13_BB B -26 ? B -13 ? B -25 ? B -14 ? 
1 B U  12 1_555 B A  23 1_555 B C  13 1_555 B G  22 1_555 -1.374 -0.554 3.398  -0.910   2.601   -17.123  0.157  -5.144 3.366  
-8.664  -3.030  -17.341  10 BB_U-25C-24:G-15A-14_BB B -25 ? B -14 ? B -24 ? B -15 ? 
1 B C  13 1_555 B G  22 1_555 B C  14 1_555 B G  21 1_555 0.077  -1.937 3.532  1.011    1.387   28.373   -4.283 0.091  3.436  
2.825   -2.060  28.424   11 BB_C-24C-23:G-16G-15_BB B -24 ? B -15 ? B -23 ? B -16 ? 
1 B C  14 1_555 B G  21 1_555 B C  15 1_555 B G  20 1_555 -0.288 -2.021 3.593  -3.750   6.506   29.985   -5.107 -0.216 3.109  
12.332  7.108   30.890   12 BB_C-23C-22:G-17G-16_BB B -23 ? B -16 ? B -22 ? B -17 ? 
1 B C  37 1_555 C DG 34 1_555 B U  38 1_555 C DA 33 1_555 -1.163 -0.822 3.172  -0.623   4.243   14.175   -6.595 4.015  2.852  
16.702  2.453   14.806   13 BB_C0U1:DA-1DG0_CC      B 0   ? C 0   ? B 1   ? C -1  ? 
1 B U  38 1_555 C DA 33 1_555 B C  40 1_555 C DA 32 1_555 1.844  -3.049 5.020  -4.343   13.152  50.743   -4.661 -2.486 4.010  
15.028  4.963   52.478   14 BB_U1C3:DA-2DA-1_CC     B 1   ? C -1  ? B 3   ? C -2  ? 
1 C DC 35 1_555 D DG 10 1_555 C DA 36 1_555 D DT 9  1_555 -0.605 0.849  -3.573 9.064    -6.870  -32.282  -2.578 -2.526 -3.058 
11.903  15.705  -34.177  15 CC_DC1DA2:DT7DG8_DD     C 1   ? D 8   ? C 2   ? D 7   ? 
1 C DA 36 1_555 D DT 9  1_555 C DT 37 1_555 D DA 8  1_555 0.838  3.705  -0.729 -136.100 114.976 -140.893 -1.741 0.551  -1.273 
-57.522 -68.090 -179.386 16 CC_DA2DT3:DA6DT7_DD     C 2   ? D 7   ? C 3   ? D 6   ? 
1 C DT 37 1_555 D DA 8  1_555 C DA 38 1_555 D DT 7  1_555 -0.110 -0.669 3.722  -3.478   4.947   35.678   -1.862 -0.375 3.594  
8.004   5.626   36.170   17 CC_DT3DA4:DT5DA6_DD     C 3   ? D 6   ? C 4   ? D 5   ? 
1 C DA 38 1_555 D DT 7  1_555 C DT 39 1_555 D DA 6  1_555 -0.175 -0.246 3.459  -0.666   3.983   20.614   -2.446 0.184  3.355  
10.995  1.838   21.001   18 CC_DA4DT5:DA4DT5_DD     C 4   ? D 5   ? C 5   ? D 4   ? 
1 C DT 39 1_555 D DA 6  1_555 C DC 40 1_555 D DG 5  1_555 -0.034 -0.349 3.176  -1.264   1.917   40.417   -0.711 -0.088 3.156  
2.772   1.827   40.479   19 CC_DT5DC6:DG3DA4_DD     C 5   ? D 4   ? C 6   ? D 3   ? 
1 C DC 40 1_555 D DG 5  1_555 C DG 41 1_555 D DC 4  1_555 0.532  -0.059 3.305  8.262    9.503   35.525   -1.364 0.281  3.225  
15.005  -13.046 37.623   20 CC_DC6DG7:DC2DG3_DD     C 6   ? D 3   ? C 7   ? D 2   ? 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8ZQS 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N     . PRO A 1 8   ? 130.892 142.817 137.118 1.00 44.51  ? 2   PRO A N     1 
ATOM 2    C CA    . PRO A 1 8   ? 132.249 142.320 136.870 1.00 47.25  ? 2   PRO A CA    1 
ATOM 3    C C     . PRO A 1 8   ? 132.278 141.196 135.843 1.00 48.52  ? 2   PRO A C     1 
ATOM 4    O O     . PRO A 1 8   ? 131.239 140.842 135.289 1.00 45.54  ? 2   PRO A O     1 
ATOM 5    C CB    . PRO A 1 8   ? 132.692 141.809 138.244 1.00 41.99  ? 2   PRO A CB    1 
ATOM 6    C CG    . PRO A 1 8   ? 131.843 142.544 139.219 1.00 42.25  ? 2   PRO A CG    1 
ATOM 7    C CD    . PRO A 1 8   ? 130.525 142.735 138.542 1.00 43.92  ? 2   PRO A CD    1 
ATOM 8    N N     . SER A 1 9   ? 133.461 140.645 135.597 1.00 35.56  ? 3   SER A N     1 
ATOM 9    C CA    . SER A 1 9   ? 133.646 139.534 134.673 1.00 29.32  ? 3   SER A CA    1 
ATOM 10   C C     . SER A 1 9   ? 134.017 138.297 135.478 1.00 41.10  ? 3   SER A C     1 
ATOM 11   O O     . SER A 1 9   ? 134.985 138.323 136.245 1.00 46.86  ? 3   SER A O     1 
ATOM 12   C CB    . SER A 1 9   ? 134.725 139.857 133.641 1.00 39.85  ? 3   SER A CB    1 
ATOM 13   O OG    . SER A 1 9   ? 134.613 141.192 133.185 1.00 47.47  ? 3   SER A OG    1 
ATOM 14   N N     . TYR A 1 10  ? 133.228 137.239 135.310 1.00 37.21  ? 4   TYR A N     1 
ATOM 15   C CA    . TYR A 1 10  ? 133.437 136.036 136.103 1.00 31.30  ? 4   TYR A CA    1 
ATOM 16   C C     . TYR A 1 10  ? 133.646 134.765 135.320 1.00 34.33  ? 4   TYR A C     1 
ATOM 17   O O     . TYR A 1 10  ? 133.120 134.608 134.218 1.00 48.36  ? 4   TYR A O     1 
ATOM 18   C CB    . TYR A 1 10  ? 132.215 135.796 136.995 1.00 28.59  ? 4   TYR A CB    1 
ATOM 19   C CG    . TYR A 1 10  ? 132.065 136.746 138.155 1.00 29.95  ? 4   TYR A CG    1 
ATOM 20   C CD1   . TYR A 1 10  ? 132.474 136.382 139.429 1.00 26.61  ? 4   TYR A CD1   1 
ATOM 21   C CD2   . TYR A 1 10  ? 131.491 137.997 137.982 1.00 34.33  ? 4   TYR A CD2   1 
ATOM 22   C CE1   . TYR A 1 10  ? 132.328 137.243 140.498 1.00 33.11  ? 4   TYR A CE1   1 
ATOM 23   C CE2   . TYR A 1 10  ? 131.342 138.865 139.044 1.00 31.77  ? 4   TYR A CE2   1 
ATOM 24   C CZ    . TYR A 1 10  ? 131.761 138.483 140.299 1.00 31.64  ? 4   TYR A CZ    1 
ATOM 25   O OH    . TYR A 1 10  ? 131.616 139.347 141.359 1.00 44.74  ? 4   TYR A OH    1 
ATOM 26   N N     . LYS A 1 11  ? 134.407 133.849 135.890 1.00 31.81  ? 5   LYS A N     1 
ATOM 27   C CA    . LYS A 1 11  ? 134.616 132.540 135.294 1.00 22.92  ? 5   LYS A CA    1 
ATOM 28   C C     . LYS A 1 11  ? 134.553 131.502 136.402 1.00 35.13  ? 5   LYS A C     1 
ATOM 29   O O     . LYS A 1 11  ? 134.957 131.763 137.538 1.00 48.45  ? 5   LYS A O     1 
ATOM 30   C CB    . LYS A 1 11  ? 135.947 132.458 134.542 1.00 30.36  ? 5   LYS A CB    1 
ATOM 31   C CG    . LYS A 1 11  ? 135.831 132.760 133.059 1.00 33.91  ? 5   LYS A CG    1 
ATOM 32   C CD    . LYS A 1 11  ? 137.194 132.979 132.430 1.00 38.26  ? 5   LYS A CD    1 
ATOM 33   C CE    . LYS A 1 11  ? 137.081 133.166 130.929 1.00 35.23  ? 5   LYS A CE    1 
ATOM 34   N NZ    . LYS A 1 11  ? 135.689 133.484 130.518 1.00 37.47  ? 5   LYS A NZ    1 
ATOM 35   N N     . SER A 1 12  ? 134.049 130.317 136.068 1.00 31.71  ? 6   SER A N     1 
ATOM 36   C CA    . SER A 1 12  ? 133.755 129.307 137.072 1.00 32.59  ? 6   SER A CA    1 
ATOM 37   C C     . SER A 1 12  ? 134.318 127.953 136.668 1.00 39.57  ? 6   SER A C     1 
ATOM 38   O O     . SER A 1 12  ? 134.490 127.653 135.484 1.00 46.61  ? 6   SER A O     1 
ATOM 39   C CB    . SER A 1 12  ? 132.248 129.173 137.307 1.00 34.68  ? 6   SER A CB    1 
ATOM 40   O OG    . SER A 1 12  ? 131.972 128.173 138.270 1.00 33.05  ? 6   SER A OG    1 
ATOM 41   N N     . SER A 1 13  ? 134.602 127.146 137.684 1.00 33.05  ? 7   SER A N     1 
ATOM 42   C CA    . SER A 1 13  ? 134.959 125.745 137.528 1.00 29.51  ? 7   SER A CA    1 
ATOM 43   C C     . SER A 1 13  ? 134.814 125.087 138.891 1.00 28.75  ? 7   SER A C     1 
ATOM 44   O O     . SER A 1 13  ? 134.850 125.755 139.928 1.00 38.13  ? 7   SER A O     1 
ATOM 45   C CB    . SER A 1 13  ? 136.377 125.571 136.981 1.00 38.54  ? 7   SER A CB    1 
ATOM 46   O OG    . SER A 1 13  ? 136.680 124.203 136.779 1.00 36.38  ? 7   SER A OG    1 
ATOM 47   N N     . ARG A 1 14  ? 134.665 123.768 138.881 1.00 39.70  ? 8   ARG A N     1 
ATOM 48   C CA    . ARG A 1 14  ? 134.388 123.025 140.098 1.00 38.32  ? 8   ARG A CA    1 
ATOM 49   C C     . ARG A 1 14  ? 135.606 122.236 140.552 1.00 39.69  ? 8   ARG A C     1 
ATOM 50   O O     . ARG A 1 14  ? 136.449 121.835 139.745 1.00 40.81  ? 8   ARG A O     1 
ATOM 51   C CB    . ARG A 1 14  ? 133.210 122.071 139.910 1.00 29.64  ? 8   ARG A CB    1 
ATOM 52   C CG    . ARG A 1 14  ? 131.867 122.741 140.032 1.00 36.22  ? 8   ARG A CG    1 
ATOM 53   C CD    . ARG A 1 14  ? 130.736 121.747 139.893 1.00 39.98  ? 8   ARG A CD    1 
ATOM 54   N NE    . ARG A 1 14  ? 131.013 120.735 138.883 1.00 42.02  ? 8   ARG A NE    1 
ATOM 55   C CZ    . ARG A 1 14  ? 130.084 119.983 138.312 1.00 43.94  ? 8   ARG A CZ    1 
ATOM 56   N NH1   . ARG A 1 14  ? 128.803 120.121 138.613 1.00 38.27  ? 8   ARG A NH1   1 
ATOM 57   N NH2   . ARG A 1 14  ? 130.447 119.071 137.417 1.00 45.47  ? 8   ARG A NH2   1 
ATOM 58   N N     . VAL A 1 15  ? 135.684 122.026 141.864 1.00 39.85  ? 9   VAL A N     1 
ATOM 59   C CA    . VAL A 1 15  ? 136.637 121.103 142.460 1.00 35.54  ? 9   VAL A CA    1 
ATOM 60   C C     . VAL A 1 15  ? 135.860 120.145 143.351 1.00 36.96  ? 9   VAL A C     1 
ATOM 61   O O     . VAL A 1 15  ? 134.769 120.451 143.835 1.00 46.64  ? 9   VAL A O     1 
ATOM 62   C CB    . VAL A 1 15  ? 137.746 121.819 143.261 1.00 28.48  ? 9   VAL A CB    1 
ATOM 63   C CG1   . VAL A 1 15  ? 138.611 122.660 142.339 1.00 26.48  ? 9   VAL A CG1   1 
ATOM 64   C CG2   . VAL A 1 15  ? 137.145 122.672 144.359 1.00 33.32  ? 9   VAL A CG2   1 
ATOM 65   N N     . LEU A 1 16  ? 136.435 118.966 143.553 1.00 30.53  ? 10  LEU A N     1 
ATOM 66   C CA    . LEU A 1 16  ? 135.776 117.880 144.264 1.00 34.36  ? 10  LEU A CA    1 
ATOM 67   C C     . LEU A 1 16  ? 136.420 117.692 145.630 1.00 43.87  ? 10  LEU A C     1 
ATOM 68   O O     . LEU A 1 16  ? 137.651 117.659 145.739 1.00 52.24  ? 10  LEU A O     1 
ATOM 69   C CB    . LEU A 1 16  ? 135.853 116.583 143.456 1.00 45.05  ? 10  LEU A CB    1 
ATOM 70   C CG    . LEU A 1 16  ? 135.122 115.352 143.991 1.00 43.30  ? 10  LEU A CG    1 
ATOM 71   C CD1   . LEU A 1 16  ? 133.692 115.690 144.349 1.00 48.09  ? 10  LEU A CD1   1 
ATOM 72   C CD2   . LEU A 1 16  ? 135.163 114.232 142.971 1.00 43.92  ? 10  LEU A CD2   1 
ATOM 73   N N     . VAL A 1 17  ? 135.593 117.577 146.664 1.00 43.00  ? 11  VAL A N     1 
ATOM 74   C CA    . VAL A 1 17  ? 136.039 117.217 148.004 1.00 50.87  ? 11  VAL A CA    1 
ATOM 75   C C     . VAL A 1 17  ? 135.434 115.861 148.346 1.00 50.11  ? 11  VAL A C     1 
ATOM 76   O O     . VAL A 1 17  ? 134.219 115.663 148.216 1.00 46.64  ? 11  VAL A O     1 
ATOM 77   C CB    . VAL A 1 17  ? 135.664 118.291 149.042 1.00 49.16  ? 11  VAL A CB    1 
ATOM 78   C CG1   . VAL A 1 17  ? 136.443 119.566 148.777 1.00 45.45  ? 11  VAL A CG1   1 
ATOM 79   C CG2   . VAL A 1 17  ? 134.175 118.587 149.010 1.00 45.37  ? 11  VAL A CG2   1 
ATOM 80   N N     . ARG A 1 18  ? 136.283 114.921 148.759 1.00 57.36  ? 12  ARG A N     1 
ATOM 81   C CA    . ARG A 1 18  ? 135.876 113.527 148.900 1.00 62.46  ? 12  ARG A CA    1 
ATOM 82   C C     . ARG A 1 18  ? 135.436 113.185 150.322 1.00 63.10  ? 12  ARG A C     1 
ATOM 83   O O     . ARG A 1 18  ? 134.302 112.750 150.534 1.00 60.43  ? 12  ARG A O     1 
ATOM 84   C CB    . ARG A 1 18  ? 137.018 112.607 148.452 1.00 63.53  ? 12  ARG A CB    1 
ATOM 85   C CG    . ARG A 1 18  ? 137.035 112.339 146.956 1.00 59.74  ? 12  ARG A CG    1 
ATOM 86   C CD    . ARG A 1 18  ? 137.935 111.168 146.610 1.00 56.14  ? 12  ARG A CD    1 
ATOM 87   N NE    . ARG A 1 18  ? 138.455 111.265 145.251 1.00 56.49  ? 12  ARG A NE    1 
ATOM 88   C CZ    . ARG A 1 18  ? 137.819 110.831 144.172 1.00 61.25  ? 12  ARG A CZ    1 
ATOM 89   N NH1   . ARG A 1 18  ? 136.628 110.264 144.255 1.00 61.75  ? 12  ARG A NH1   1 
ATOM 90   N NH2   . ARG A 1 18  ? 138.391 110.974 142.981 1.00 62.43  ? 12  ARG A NH2   1 
ATOM 91   N N     . ASP A 1 19  ? 136.318 113.371 151.301 1.00 64.05  ? 13  ASP A N     1 
ATOM 92   C CA    . ASP A 1 19  ? 136.031 112.980 152.680 1.00 62.60  ? 13  ASP A CA    1 
ATOM 93   C C     . ASP A 1 19  ? 135.525 114.186 153.470 1.00 65.82  ? 13  ASP A C     1 
ATOM 94   O O     . ASP A 1 19  ? 136.203 114.744 154.332 1.00 66.19  ? 13  ASP A O     1 
ATOM 95   C CB    . ASP A 1 19  ? 137.269 112.364 153.323 1.00 67.17  ? 13  ASP A CB    1 
ATOM 96   C CG    . ASP A 1 19  ? 137.284 110.852 153.225 1.00 70.07  ? 13  ASP A CG    1 
ATOM 97   O OD1   . ASP A 1 19  ? 136.415 110.207 153.848 1.00 69.35  ? 13  ASP A OD1   1 
ATOM 98   O OD2   . ASP A 1 19  ? 138.165 110.308 152.526 1.00 70.44  ? 13  ASP A OD2   1 
ATOM 99   N N     . ARG A 1 30  ? 123.683 119.058 156.505 1.00 71.31  ? 24  ARG A N     1 
ATOM 100  C CA    . ARG A 1 30  ? 122.885 120.109 157.116 1.00 70.55  ? 24  ARG A CA    1 
ATOM 101  C C     . ARG A 1 30  ? 122.790 121.355 156.244 1.00 71.53  ? 24  ARG A C     1 
ATOM 102  O O     . ARG A 1 30  ? 121.759 122.030 156.235 1.00 77.94  ? 24  ARG A O     1 
ATOM 103  C CB    . ARG A 1 30  ? 123.482 120.472 158.475 1.00 74.34  ? 24  ARG A CB    1 
ATOM 104  C CG    . ARG A 1 30  ? 124.150 121.835 158.532 1.00 75.00  ? 24  ARG A CG    1 
ATOM 105  C CD    . ARG A 1 30  ? 125.325 121.822 159.494 1.00 74.38  ? 24  ARG A CD    1 
ATOM 106  N NE    . ARG A 1 30  ? 125.158 120.817 160.539 1.00 74.56  ? 24  ARG A NE    1 
ATOM 107  C CZ    . ARG A 1 30  ? 126.000 119.811 160.746 1.00 75.40  ? 24  ARG A CZ    1 
ATOM 108  N NH1   . ARG A 1 30  ? 127.073 119.675 159.981 1.00 77.53  ? 24  ARG A NH1   1 
ATOM 109  N NH2   . ARG A 1 30  ? 125.769 118.941 161.720 1.00 72.00  ? 24  ARG A NH2   1 
ATOM 110  N N     . SER A 1 31  ? 123.848 121.665 155.499 1.00 70.66  ? 25  SER A N     1 
ATOM 111  C CA    . SER A 1 31  ? 123.846 122.906 154.720 1.00 70.90  ? 25  SER A CA    1 
ATOM 112  C C     . SER A 1 31  ? 122.816 122.864 153.601 1.00 73.02  ? 25  SER A C     1 
ATOM 113  O O     . SER A 1 31  ? 122.359 123.910 153.132 1.00 81.09  ? 25  SER A O     1 
ATOM 114  C CB    . SER A 1 31  ? 125.240 123.206 154.166 1.00 75.83  ? 25  SER A CB    1 
ATOM 115  O OG    . SER A 1 31  ? 126.218 123.149 155.190 1.00 80.53  ? 25  SER A OG    1 
ATOM 116  N N     . HIS A 1 32  ? 122.443 121.664 153.174 1.00 69.94  ? 26  HIS A N     1 
ATOM 117  C CA    . HIS A 1 32  ? 121.423 121.533 152.149 1.00 68.74  ? 26  HIS A CA    1 
ATOM 118  C C     . HIS A 1 32  ? 120.095 121.407 152.851 1.00 68.41  ? 26  HIS A C     1 
ATOM 119  O O     . HIS A 1 32  ? 119.089 122.004 152.440 1.00 74.49  ? 26  HIS A O     1 
ATOM 120  C CB    . HIS A 1 32  ? 121.684 120.311 151.279 1.00 69.23  ? 26  HIS A CB    1 
ATOM 121  C CG    . HIS A 1 32  ? 120.949 120.335 149.977 1.00 70.26  ? 26  HIS A CG    1 
ATOM 122  N ND1   . HIS A 1 32  ? 119.928 121.223 149.717 1.00 73.31  ? 26  HIS A ND1   1 
ATOM 123  C CD2   . HIS A 1 32  ? 121.086 119.581 148.860 1.00 72.27  ? 26  HIS A CD2   1 
ATOM 124  C CE1   . HIS A 1 32  ? 119.466 121.015 148.498 1.00 78.73  ? 26  HIS A CE1   1 
ATOM 125  N NE2   . HIS A 1 32  ? 120.151 120.024 147.956 1.00 78.94  ? 26  HIS A NE2   1 
ATOM 126  N N     . ARG A 1 33  ? 120.080 120.625 153.924 1.00 68.14  ? 27  ARG A N     1 
ATOM 127  C CA    . ARG A 1 33  ? 118.858 120.531 154.690 1.00 72.21  ? 27  ARG A CA    1 
ATOM 128  C C     . ARG A 1 33  ? 118.394 121.952 154.918 1.00 77.46  ? 27  ARG A C     1 
ATOM 129  O O     . ARG A 1 33  ? 117.184 122.244 154.896 1.00 81.21  ? 27  ARG A O     1 
ATOM 130  C CB    . ARG A 1 33  ? 119.092 119.821 156.015 1.00 73.69  ? 27  ARG A CB    1 
ATOM 131  C CG    . ARG A 1 33  ? 117.966 118.880 156.408 1.00 76.80  ? 27  ARG A CG    1 
ATOM 132  C CD    . ARG A 1 33  ? 118.454 117.444 156.482 1.00 77.11  ? 27  ARG A CD    1 
ATOM 133  N NE    . ARG A 1 33  ? 119.650 117.322 157.309 1.00 75.43  ? 27  ARG A NE    1 
ATOM 134  C CZ    . ARG A 1 33  ? 120.825 116.890 156.864 1.00 73.61  ? 27  ARG A CZ    1 
ATOM 135  N NH1   . ARG A 1 33  ? 120.963 116.532 155.596 1.00 72.12  ? 27  ARG A NH1   1 
ATOM 136  N NH2   . ARG A 1 33  ? 121.859 116.815 157.690 1.00 72.15  ? 27  ARG A NH2   1 
ATOM 137  N N     . VAL A 1 34  ? 119.361 122.852 155.108 1.00 68.51  ? 28  VAL A N     1 
ATOM 138  C CA    . VAL A 1 34  ? 118.980 124.230 155.396 1.00 64.16  ? 28  VAL A CA    1 
ATOM 139  C C     . VAL A 1 34  ? 118.789 125.021 154.109 1.00 74.80  ? 28  VAL A C     1 
ATOM 140  O O     . VAL A 1 34  ? 117.976 125.949 154.067 1.00 86.18  ? 28  VAL A O     1 
ATOM 141  C CB    . VAL A 1 34  ? 120.000 124.906 156.332 1.00 68.67  ? 28  VAL A CB    1 
ATOM 142  C CG1   . VAL A 1 34  ? 120.085 124.160 157.651 1.00 73.80  ? 28  VAL A CG1   1 
ATOM 143  C CG2   . VAL A 1 34  ? 121.356 125.008 155.680 1.00 72.56  ? 28  VAL A CG2   1 
ATOM 144  N N     . ALA A 1 35  ? 119.513 124.680 153.042 1.00 80.08  ? 29  ALA A N     1 
ATOM 145  C CA    . ALA A 1 35  ? 119.292 125.352 151.766 1.00 79.13  ? 29  ALA A CA    1 
ATOM 146  C C     . ALA A 1 35  ? 117.925 125.010 151.190 1.00 81.00  ? 29  ALA A C     1 
ATOM 147  O O     . ALA A 1 35  ? 117.228 125.889 150.665 1.00 87.15  ? 29  ALA A O     1 
ATOM 148  C CB    . ALA A 1 35  ? 120.396 124.982 150.783 1.00 78.02  ? 29  ALA A CB    1 
ATOM 149  N N     . ALA A 1 36  ? 117.531 123.739 151.267 1.00 69.84  ? 30  ALA A N     1 
ATOM 150  C CA    . ALA A 1 36  ? 116.185 123.367 150.842 1.00 74.26  ? 30  ALA A CA    1 
ATOM 151  C C     . ALA A 1 36  ? 115.139 124.079 151.686 1.00 77.34  ? 30  ALA A C     1 
ATOM 152  O O     . ALA A 1 36  ? 114.120 124.556 151.164 1.00 81.65  ? 30  ALA A O     1 
ATOM 153  C CB    . ALA A 1 36  ? 116.008 121.852 150.922 1.00 76.38  ? 30  ALA A CB    1 
ATOM 154  N N     . PHE A 1 37  ? 115.381 124.169 152.995 1.00 76.57  ? 31  PHE A N     1 
ATOM 155  C CA    . PHE A 1 37  ? 114.469 124.897 153.867 1.00 75.79  ? 31  PHE A CA    1 
ATOM 156  C C     . PHE A 1 37  ? 114.370 126.360 153.460 1.00 77.27  ? 31  PHE A C     1 
ATOM 157  O O     . PHE A 1 37  ? 113.279 126.934 153.461 1.00 84.34  ? 31  PHE A O     1 
ATOM 158  C CB    . PHE A 1 37  ? 114.927 124.779 155.320 1.00 75.01  ? 31  PHE A CB    1 
ATOM 159  C CG    . PHE A 1 37  ? 114.178 125.669 156.263 1.00 76.27  ? 31  PHE A CG    1 
ATOM 160  C CD1   . PHE A 1 37  ? 112.913 125.325 156.702 1.00 78.68  ? 31  PHE A CD1   1 
ATOM 161  C CD2   . PHE A 1 37  ? 114.739 126.849 156.714 1.00 78.90  ? 31  PHE A CD2   1 
ATOM 162  C CE1   . PHE A 1 37  ? 112.224 126.142 157.572 1.00 80.02  ? 31  PHE A CE1   1 
ATOM 163  C CE2   . PHE A 1 37  ? 114.052 127.668 157.583 1.00 81.84  ? 31  PHE A CE2   1 
ATOM 164  C CZ    . PHE A 1 37  ? 112.794 127.315 158.011 1.00 82.48  ? 31  PHE A CZ    1 
ATOM 165  N N     . PHE A 1 38  ? 115.497 126.981 153.117 1.00 75.54  ? 32  PHE A N     1 
ATOM 166  C CA    . PHE A 1 38  ? 115.485 128.382 152.714 1.00 72.95  ? 32  PHE A CA    1 
ATOM 167  C C     . PHE A 1 38  ? 114.717 128.582 151.416 1.00 79.84  ? 32  PHE A C     1 
ATOM 168  O O     . PHE A 1 38  ? 113.934 129.532 151.294 1.00 85.38  ? 32  PHE A O     1 
ATOM 169  C CB    . PHE A 1 38  ? 116.915 128.899 152.573 1.00 78.13  ? 32  PHE A CB    1 
ATOM 170  C CG    . PHE A 1 38  ? 117.498 129.430 153.850 1.00 80.04  ? 32  PHE A CG    1 
ATOM 171  C CD1   . PHE A 1 38  ? 116.689 130.017 154.803 1.00 76.68  ? 32  PHE A CD1   1 
ATOM 172  C CD2   . PHE A 1 38  ? 118.856 129.341 154.095 1.00 79.54  ? 32  PHE A CD2   1 
ATOM 173  C CE1   . PHE A 1 38  ? 117.223 130.507 155.976 1.00 75.62  ? 32  PHE A CE1   1 
ATOM 174  C CE2   . PHE A 1 38  ? 119.396 129.829 155.267 1.00 77.38  ? 32  PHE A CE2   1 
ATOM 175  C CZ    . PHE A 1 38  ? 118.578 130.411 156.208 1.00 76.75  ? 32  PHE A CZ    1 
ATOM 176  N N     . MET A 1 39  ? 114.932 127.704 150.431 1.00 81.04  ? 33  MET A N     1 
ATOM 177  C CA    . MET A 1 39  ? 114.178 127.809 149.185 1.00 78.63  ? 33  MET A CA    1 
ATOM 178  C C     . MET A 1 39  ? 112.684 127.693 149.439 1.00 75.96  ? 33  MET A C     1 
ATOM 179  O O     . MET A 1 39  ? 111.891 128.510 148.951 1.00 82.44  ? 33  MET A O     1 
ATOM 180  C CB    . MET A 1 39  ? 114.618 126.744 148.183 1.00 74.57  ? 33  MET A CB    1 
ATOM 181  C CG    . MET A 1 39  ? 116.073 126.783 147.798 1.00 79.53  ? 33  MET A CG    1 
ATOM 182  S SD    . MET A 1 39  ? 116.350 125.804 146.315 1.00 91.01  ? 33  MET A SD    1 
ATOM 183  C CE    . MET A 1 39  ? 115.029 126.397 145.266 1.00 81.26  ? 33  MET A CE    1 
ATOM 184  N N     . ARG A 1 40  ? 112.279 126.680 150.206 1.00 69.04  ? 34  ARG A N     1 
ATOM 185  C CA    . ARG A 1 40  ? 110.859 126.496 150.470 1.00 72.74  ? 34  ARG A CA    1 
ATOM 186  C C     . ARG A 1 40  ? 110.290 127.667 151.260 1.00 73.97  ? 34  ARG A C     1 
ATOM 187  O O     . ARG A 1 40  ? 109.168 128.112 151.000 1.00 78.84  ? 34  ARG A O     1 
ATOM 188  C CB    . ARG A 1 40  ? 110.631 125.179 151.206 1.00 79.08  ? 34  ARG A CB    1 
ATOM 189  C CG    . ARG A 1 40  ? 110.123 124.057 150.321 1.00 79.66  ? 34  ARG A CG    1 
ATOM 190  C CD    . ARG A 1 40  ? 109.623 122.894 151.156 1.00 76.10  ? 34  ARG A CD    1 
ATOM 191  N NE    . ARG A 1 40  ? 110.658 122.378 152.041 1.00 80.57  ? 34  ARG A NE    1 
ATOM 192  C CZ    . ARG A 1 40  ? 111.255 121.205 151.888 1.00 82.35  ? 34  ARG A CZ    1 
ATOM 193  N NH1   . ARG A 1 40  ? 110.934 120.391 150.896 1.00 80.09  ? 34  ARG A NH1   1 
ATOM 194  N NH2   . ARG A 1 40  ? 112.196 120.837 152.754 1.00 81.93  ? 34  ARG A NH2   1 
ATOM 195  N N     . LEU A 1 41  ? 111.056 128.189 152.219 1.00 76.39  ? 35  LEU A N     1 
ATOM 196  C CA    . LEU A 1 41  ? 110.588 129.303 153.032 1.00 75.55  ? 35  LEU A CA    1 
ATOM 197  C C     . LEU A 1 41  ? 110.389 130.557 152.195 1.00 72.91  ? 35  LEU A C     1 
ATOM 198  O O     . LEU A 1 41  ? 109.393 131.267 152.361 1.00 80.70  ? 35  LEU A O     1 
ATOM 199  C CB    . LEU A 1 41  ? 111.576 129.568 154.166 1.00 80.14  ? 35  LEU A CB    1 
ATOM 200  C CG    . LEU A 1 41  ? 111.168 130.583 155.231 1.00 82.92  ? 35  LEU A CG    1 
ATOM 201  C CD1   . LEU A 1 41  ? 109.716 130.392 155.638 1.00 81.90  ? 35  LEU A CD1   1 
ATOM 202  C CD2   . LEU A 1 41  ? 112.083 130.496 156.440 1.00 80.90  ? 35  LEU A CD2   1 
ATOM 203  N N     . LEU A 1 42  ? 111.327 130.854 151.297 1.00 66.97  ? 36  LEU A N     1 
ATOM 204  C CA    . LEU A 1 42  ? 111.170 132.025 150.443 1.00 70.64  ? 36  LEU A CA    1 
ATOM 205  C C     . LEU A 1 42  ? 110.008 131.850 149.473 1.00 78.37  ? 36  LEU A C     1 
ATOM 206  O O     . LEU A 1 42  ? 109.226 132.785 149.258 1.00 79.39  ? 36  LEU A O     1 
ATOM 207  C CB    . LEU A 1 42  ? 112.466 132.302 149.690 1.00 72.22  ? 36  LEU A CB    1 
ATOM 208  C CG    . LEU A 1 42  ? 113.655 132.742 150.539 1.00 77.56  ? 36  LEU A CG    1 
ATOM 209  C CD1   . LEU A 1 42  ? 114.962 132.384 149.851 1.00 77.72  ? 36  LEU A CD1   1 
ATOM 210  C CD2   . LEU A 1 42  ? 113.582 134.231 150.816 1.00 75.36  ? 36  LEU A CD2   1 
ATOM 211  N N     . LEU A 1 43  ? 109.838 130.657 148.922 1.00 80.53  ? 37  LEU A N     1 
ATOM 212  C CA    . LEU A 1 43  ? 108.683 130.421 148.063 1.00 73.68  ? 37  LEU A CA    1 
ATOM 213  C C     . LEU A 1 43  ? 107.410 130.401 148.893 1.00 72.64  ? 37  LEU A C     1 
ATOM 214  O O     . LEU A 1 43  ? 106.517 131.234 148.695 1.00 78.27  ? 37  LEU A O     1 
ATOM 215  C CB    . LEU A 1 43  ? 108.831 129.100 147.312 1.00 70.90  ? 37  LEU A CB    1 
ATOM 216  C CG    . LEU A 1 43  ? 110.085 128.937 146.454 1.00 72.42  ? 37  LEU A CG    1 
ATOM 217  C CD1   . LEU A 1 43  ? 110.292 127.476 146.086 1.00 77.80  ? 37  LEU A CD1   1 
ATOM 218  C CD2   . LEU A 1 43  ? 109.996 129.804 145.207 1.00 74.01  ? 37  LEU A CD2   1 
ATOM 219  N N     . ALA A 1 44  ? 107.321 129.461 149.826 1.00 74.44  ? 38  ALA A N     1 
ATOM 220  C CA    . ALA A 1 44  ? 106.146 129.374 150.686 1.00 79.17  ? 38  ALA A CA    1 
ATOM 221  C C     . ALA A 1 44  ? 106.275 130.315 151.877 1.00 76.07  ? 38  ALA A C     1 
ATOM 222  O O     . ALA A 1 44  ? 106.629 131.484 151.721 1.00 79.03  ? 38  ALA A O     1 
ATOM 223  C CB    . ALA A 1 44  ? 105.939 127.943 151.157 1.00 82.08  ? 38  ALA A CB    1 
ATOM 224  N N     . GLY A 1 75  ? 107.722 127.938 161.939 1.00 71.95  ? 69  GLY A N     1 
ATOM 225  C CA    . GLY A 1 75  ? 107.384 128.825 163.032 1.00 70.93  ? 69  GLY A CA    1 
ATOM 226  C C     . GLY A 1 75  ? 106.160 129.671 162.756 1.00 77.67  ? 69  GLY A C     1 
ATOM 227  O O     . GLY A 1 75  ? 105.586 130.261 163.675 1.00 82.87  ? 69  GLY A O     1 
ATOM 228  N N     . CYS A 1 76  ? 105.745 129.736 161.494 1.00 97.42  ? 70  CYS A N     1 
ATOM 229  C CA    . CYS A 1 76  ? 104.596 130.547 161.095 1.00 99.84  ? 70  CYS A CA    1 
ATOM 230  C C     . CYS A 1 76  ? 103.328 129.827 161.530 1.00 97.20  ? 70  CYS A C     1 
ATOM 231  O O     . CYS A 1 76  ? 102.770 129.005 160.804 1.00 100.54 ? 70  CYS A O     1 
ATOM 232  C CB    . CYS A 1 76  ? 104.608 130.801 159.593 1.00 104.55 ? 70  CYS A CB    1 
ATOM 233  S SG    . CYS A 1 76  ? 105.444 132.325 159.097 1.00 112.70 ? 70  CYS A SG    1 
ATOM 234  N N     . GLU A 1 77  ? 102.867 130.141 162.742 1.00 101.41 ? 71  GLU A N     1 
ATOM 235  C CA    . GLU A 1 77  ? 101.659 129.505 163.256 1.00 106.77 ? 71  GLU A CA    1 
ATOM 236  C C     . GLU A 1 77  ? 100.421 129.942 162.486 1.00 107.96 ? 71  GLU A C     1 
ATOM 237  O O     . GLU A 1 77  ? 99.486  129.151 162.320 1.00 111.04 ? 71  GLU A O     1 
ATOM 238  C CB    . GLU A 1 77  ? 101.498 129.813 164.746 1.00 105.85 ? 71  GLU A CB    1 
ATOM 239  C CG    . GLU A 1 77  ? 102.720 129.487 165.602 1.00 108.13 ? 71  GLU A CG    1 
ATOM 240  C CD    . GLU A 1 77  ? 103.363 128.148 165.269 1.00 109.75 ? 71  GLU A CD    1 
ATOM 241  O OE1   . GLU A 1 77  ? 102.631 127.180 164.966 1.00 108.86 ? 71  GLU A OE1   1 
ATOM 242  O OE2   . GLU A 1 77  ? 104.608 128.065 165.309 1.00 110.37 ? 71  GLU A OE2   1 
ATOM 243  N N     . GLU A 1 78  ? 100.393 131.184 162.011 1.00 105.68 ? 72  GLU A N     1 
ATOM 244  C CA    . GLU A 1 78  ? 99.279  131.713 161.226 1.00 106.96 ? 72  GLU A CA    1 
ATOM 245  C C     . GLU A 1 78  ? 99.835  132.362 159.967 1.00 109.15 ? 72  GLU A C     1 
ATOM 246  O O     . GLU A 1 78  ? 99.857  133.593 159.842 1.00 113.86 ? 72  GLU A O     1 
ATOM 247  C CB    . GLU A 1 78  ? 98.457  132.711 162.044 1.00 109.97 ? 72  GLU A CB    1 
ATOM 248  C CG    . GLU A 1 78  ? 97.592  132.070 163.115 1.00 111.28 ? 72  GLU A CG    1 
ATOM 249  C CD    . GLU A 1 78  ? 96.426  131.295 162.537 1.00 113.35 ? 72  GLU A CD    1 
ATOM 250  O OE1   . GLU A 1 78  ? 95.539  131.923 161.920 1.00 113.48 ? 72  GLU A OE1   1 
ATOM 251  O OE2   . GLU A 1 78  ? 96.396  130.057 162.697 1.00 112.65 ? 72  GLU A OE2   1 
ATOM 252  N N     . PRO A 1 79  ? 100.309 131.556 159.013 1.00 102.42 ? 73  PRO A N     1 
ATOM 253  C CA    . PRO A 1 79  ? 100.920 132.134 157.804 1.00 106.69 ? 73  PRO A CA    1 
ATOM 254  C C     . PRO A 1 79  ? 99.972  133.006 157.003 1.00 109.24 ? 73  PRO A C     1 
ATOM 255  O O     . PRO A 1 79  ? 100.412 134.000 156.411 1.00 110.15 ? 73  PRO A O     1 
ATOM 256  C CB    . PRO A 1 79  ? 101.359 130.898 157.005 1.00 103.67 ? 73  PRO A CB    1 
ATOM 257  C CG    . PRO A 1 79  ? 101.337 129.763 157.978 1.00 102.64 ? 73  PRO A CG    1 
ATOM 258  C CD    . PRO A 1 79  ? 100.256 130.088 158.953 1.00 101.83 ? 73  PRO A CD    1 
ATOM 259  N N     . ASP A 1 80  ? 98.684  132.664 156.964 1.00 108.00 ? 74  ASP A N     1 
ATOM 260  C CA    . ASP A 1 80  ? 97.731  133.463 156.201 1.00 107.07 ? 74  ASP A CA    1 
ATOM 261  C C     . ASP A 1 80  ? 97.582  134.860 156.787 1.00 105.32 ? 74  ASP A C     1 
ATOM 262  O O     . ASP A 1 80  ? 97.486  135.845 156.047 1.00 106.94 ? 74  ASP A O     1 
ATOM 263  C CB    . ASP A 1 80  ? 96.379  132.751 156.145 1.00 109.13 ? 74  ASP A CB    1 
ATOM 264  C CG    . ASP A 1 80  ? 95.815  132.459 157.523 1.00 113.15 ? 74  ASP A CG    1 
ATOM 265  O OD1   . ASP A 1 80  ? 96.566  132.584 158.513 1.00 112.34 ? 74  ASP A OD1   1 
ATOM 266  O OD2   . ASP A 1 80  ? 94.621  132.105 157.615 1.00 113.86 ? 74  ASP A OD2   1 
ATOM 267  N N     . ALA A 1 81  ? 97.560  134.967 158.118 1.00 96.19  ? 75  ALA A N     1 
ATOM 268  C CA    . ALA A 1 81  ? 97.356  136.257 158.763 1.00 96.33  ? 75  ALA A CA    1 
ATOM 269  C C     . ALA A 1 81  ? 98.480  137.240 158.470 1.00 99.38  ? 75  ALA A C     1 
ATOM 270  O O     . ALA A 1 81  ? 98.263  138.453 158.559 1.00 104.31 ? 75  ALA A O     1 
ATOM 271  C CB    . ALA A 1 81  ? 97.211  136.073 160.274 1.00 97.79  ? 75  ALA A CB    1 
ATOM 272  N N     . VAL A 1 82  ? 99.667  136.751 158.124 1.00 91.67  ? 76  VAL A N     1 
ATOM 273  C CA    . VAL A 1 82  ? 100.809 137.614 157.848 1.00 94.34  ? 76  VAL A CA    1 
ATOM 274  C C     . VAL A 1 82  ? 101.287 137.333 156.427 1.00 92.25  ? 76  VAL A C     1 
ATOM 275  O O     . VAL A 1 82  ? 102.469 137.495 156.099 1.00 97.67  ? 76  VAL A O     1 
ATOM 276  C CB    . VAL A 1 82  ? 101.908 137.407 158.911 1.00 97.82  ? 76  VAL A CB    1 
ATOM 277  C CG1   . VAL A 1 82  ? 102.583 136.047 158.760 1.00 94.33  ? 76  VAL A CG1   1 
ATOM 278  C CG2   . VAL A 1 82  ? 102.914 138.556 158.904 1.00 97.24  ? 76  VAL A CG2   1 
ATOM 279  N N     . SER A 1 83  ? 100.351 136.939 155.562 1.00 90.91  ? 77  SER A N     1 
ATOM 280  C CA    . SER A 1 83  ? 100.709 136.498 154.218 1.00 94.12  ? 77  SER A CA    1 
ATOM 281  C C     . SER A 1 83  ? 101.314 137.626 153.391 1.00 90.98  ? 77  SER A C     1 
ATOM 282  O O     . SER A 1 83  ? 102.267 137.404 152.637 1.00 94.32  ? 77  SER A O     1 
ATOM 283  C CB    . SER A 1 83  ? 99.482  135.920 153.514 1.00 96.66  ? 77  SER A CB    1 
ATOM 284  O OG    . SER A 1 83  ? 98.431  136.869 153.467 1.00 96.61  ? 77  SER A OG    1 
ATOM 285  N N     . ASP A 1 84  ? 100.766 138.837 153.498 1.00 83.84  ? 78  ASP A N     1 
ATOM 286  C CA    . ASP A 1 84  ? 101.201 139.924 152.626 1.00 85.49  ? 78  ASP A CA    1 
ATOM 287  C C     . ASP A 1 84  ? 102.644 140.323 152.911 1.00 84.52  ? 78  ASP A C     1 
ATOM 288  O O     . ASP A 1 84  ? 103.452 140.479 151.986 1.00 88.89  ? 78  ASP A O     1 
ATOM 289  C CB    . ASP A 1 84  ? 100.270 141.125 152.784 1.00 92.27  ? 78  ASP A CB    1 
ATOM 290  C CG    . ASP A 1 84  ? 98.890  140.872 152.208 1.00 96.33  ? 78  ASP A CG    1 
ATOM 291  O OD1   . ASP A 1 84  ? 98.801  140.487 151.024 1.00 95.75  ? 78  ASP A OD1   1 
ATOM 292  O OD2   . ASP A 1 84  ? 97.896  141.059 152.940 1.00 94.95  ? 78  ASP A OD2   1 
ATOM 293  N N     . ASP A 1 85  ? 102.969 140.494 154.187 1.00 86.30  ? 79  ASP A N     1 
ATOM 294  C CA    . ASP A 1 85  ? 104.330 140.848 154.564 1.00 93.93  ? 79  ASP A CA    1 
ATOM 295  C C     . ASP A 1 85  ? 105.278 139.748 154.133 1.00 93.39  ? 79  ASP A C     1 
ATOM 296  O O     . ASP A 1 85  ? 106.316 140.011 153.527 1.00 92.29  ? 79  ASP A O     1 
ATOM 297  C CB    . ASP A 1 85  ? 104.428 141.064 156.072 1.00 94.64  ? 79  ASP A CB    1 
ATOM 298  C CG    . ASP A 1 85  ? 103.077 141.314 156.715 1.00 98.62  ? 79  ASP A CG    1 
ATOM 299  O OD1   . ASP A 1 85  ? 102.180 140.455 156.580 1.00 97.82  ? 79  ASP A OD1   1 
ATOM 300  O OD2   . ASP A 1 85  ? 102.911 142.372 157.358 1.00 99.59  ? 79  ASP A OD2   1 
ATOM 301  N N     . LEU A 1 86  ? 104.922 138.508 154.444 1.00 81.17  ? 80  LEU A N     1 
ATOM 302  C CA    . LEU A 1 86  ? 105.756 137.381 154.045 1.00 71.59  ? 80  LEU A CA    1 
ATOM 303  C C     . LEU A 1 86  ? 106.026 137.411 152.551 1.00 72.21  ? 80  LEU A C     1 
ATOM 304  O O     . LEU A 1 86  ? 107.160 137.185 152.111 1.00 80.14  ? 80  LEU A O     1 
ATOM 305  C CB    . LEU A 1 86  ? 105.088 136.061 154.424 1.00 71.54  ? 80  LEU A CB    1 
ATOM 306  C CG    . LEU A 1 86  ? 105.169 135.595 155.874 1.00 77.99  ? 80  LEU A CG    1 
ATOM 307  C CD1   . LEU A 1 86  ? 104.265 134.397 156.081 1.00 78.35  ? 80  LEU A CD1   1 
ATOM 308  C CD2   . LEU A 1 86  ? 106.600 135.261 156.245 1.00 79.45  ? 80  LEU A CD2   1 
ATOM 309  N N     . ARG A 1 87  ? 104.991 137.674 151.753 1.00 76.69  ? 81  ARG A N     1 
ATOM 310  C CA    . ARG A 1 87  ? 105.164 137.725 150.308 1.00 81.63  ? 81  ARG A CA    1 
ATOM 311  C C     . ARG A 1 87  ? 106.108 138.847 149.913 1.00 81.60  ? 81  ARG A C     1 
ATOM 312  O O     . ARG A 1 87  ? 106.979 138.659 149.057 1.00 89.49  ? 81  ARG A O     1 
ATOM 313  C CB    . ARG A 1 87  ? 103.807 137.895 149.624 1.00 87.28  ? 81  ARG A CB    1 
ATOM 314  C CG    . ARG A 1 87  ? 103.863 138.614 148.284 1.00 86.85  ? 81  ARG A CG    1 
ATOM 315  C CD    . ARG A 1 87  ? 104.228 137.660 147.162 1.00 83.01  ? 81  ARG A CD    1 
ATOM 316  N NE    . ARG A 1 87  ? 103.407 136.457 147.183 1.00 84.92  ? 81  ARG A NE    1 
ATOM 317  C CZ    . ARG A 1 87  ? 102.158 136.395 146.739 1.00 87.19  ? 81  ARG A CZ    1 
ATOM 318  N NH1   . ARG A 1 87  ? 101.555 137.450 146.220 1.00 87.02  ? 81  ARG A NH1   1 
ATOM 319  N NH2   . ARG A 1 87  ? 101.502 135.241 146.815 1.00 88.33  ? 81  ARG A NH2   1 
ATOM 320  N N     . SER A 1 88  ? 105.958 140.020 150.532 1.00 71.42  ? 82  SER A N     1 
ATOM 321  C CA    . SER A 1 88  ? 106.836 141.137 150.195 1.00 73.65  ? 82  SER A CA    1 
ATOM 322  C C     . SER A 1 88  ? 108.286 140.820 150.539 1.00 78.02  ? 82  SER A C     1 
ATOM 323  O O     . SER A 1 88  ? 109.189 141.075 149.735 1.00 79.10  ? 82  SER A O     1 
ATOM 324  C CB    . SER A 1 88  ? 106.377 142.406 150.909 1.00 77.38  ? 82  SER A CB    1 
ATOM 325  O OG    . SER A 1 88  ? 106.160 142.166 152.284 1.00 87.34  ? 82  SER A OG    1 
ATOM 326  N N     . PHE A 1 89  ? 108.526 140.244 151.721 1.00 79.84  ? 83  PHE A N     1 
ATOM 327  C CA    . PHE A 1 89  ? 109.889 139.877 152.096 1.00 79.50  ? 83  PHE A CA    1 
ATOM 328  C C     . PHE A 1 89  ? 110.469 138.837 151.149 1.00 71.42  ? 83  PHE A C     1 
ATOM 329  O O     . PHE A 1 89  ? 111.599 138.987 150.667 1.00 74.84  ? 83  PHE A O     1 
ATOM 330  C CB    . PHE A 1 89  ? 109.924 139.357 153.533 1.00 79.27  ? 83  PHE A CB    1 
ATOM 331  C CG    . PHE A 1 89  ? 111.215 138.676 153.898 1.00 74.77  ? 83  PHE A CG    1 
ATOM 332  C CD1   . PHE A 1 89  ? 112.320 139.412 154.280 1.00 74.16  ? 83  PHE A CD1   1 
ATOM 333  C CD2   . PHE A 1 89  ? 111.318 137.297 153.867 1.00 71.54  ? 83  PHE A CD2   1 
ATOM 334  C CE1   . PHE A 1 89  ? 113.503 138.789 154.611 1.00 70.46  ? 83  PHE A CE1   1 
ATOM 335  C CE2   . PHE A 1 89  ? 112.501 136.671 154.198 1.00 69.98  ? 83  PHE A CE2   1 
ATOM 336  C CZ    . PHE A 1 89  ? 113.593 137.417 154.571 1.00 66.89  ? 83  PHE A CZ    1 
ATOM 337  N N     . ALA A 1 90  ? 109.714 137.772 150.873 1.00 59.97  ? 84  ALA A N     1 
ATOM 338  C CA    . ALA A 1 90  ? 110.211 136.723 149.994 1.00 65.92  ? 84  ALA A CA    1 
ATOM 339  C C     . ALA A 1 90  ? 110.511 137.272 148.608 1.00 67.53  ? 84  ALA A C     1 
ATOM 340  O O     . ALA A 1 90  ? 111.523 136.918 147.995 1.00 76.97  ? 84  ALA A O     1 
ATOM 341  C CB    . ALA A 1 90  ? 109.199 135.581 149.917 1.00 70.99  ? 84  ALA A CB    1 
ATOM 342  N N     . LEU A 1 91  ? 109.646 138.150 148.104 1.00 70.83  ? 85  LEU A N     1 
ATOM 343  C CA    . LEU A 1 91  ? 109.876 138.748 146.799 1.00 72.50  ? 85  LEU A CA    1 
ATOM 344  C C     . LEU A 1 91  ? 111.116 139.630 146.814 1.00 76.95  ? 85  LEU A C     1 
ATOM 345  O O     . LEU A 1 91  ? 111.859 139.684 145.828 1.00 84.72  ? 85  LEU A O     1 
ATOM 346  C CB    . LEU A 1 91  ? 108.652 139.558 146.381 1.00 76.99  ? 85  LEU A CB    1 
ATOM 347  C CG    . LEU A 1 91  ? 107.725 138.944 145.332 1.00 80.34  ? 85  LEU A CG    1 
ATOM 348  C CD1   . LEU A 1 91  ? 106.978 140.035 144.586 1.00 79.58  ? 85  LEU A CD1   1 
ATOM 349  C CD2   . LEU A 1 91  ? 108.462 138.026 144.382 1.00 78.98  ? 85  LEU A CD2   1 
ATOM 350  N N     . ALA A 1 92  ? 111.344 140.347 147.919 1.00 74.74  ? 86  ALA A N     1 
ATOM 351  C CA    . ALA A 1 92  ? 112.525 141.199 148.022 1.00 75.99  ? 86  ALA A CA    1 
ATOM 352  C C     . ALA A 1 92  ? 113.809 140.379 148.035 1.00 76.34  ? 86  ALA A C     1 
ATOM 353  O O     . ALA A 1 92  ? 114.794 140.747 147.386 1.00 78.85  ? 86  ALA A O     1 
ATOM 354  C CB    . ALA A 1 92  ? 112.438 142.073 149.273 1.00 76.92  ? 86  ALA A CB    1 
ATOM 355  N N     . VAL A 1 93  ? 113.823 139.269 148.774 1.00 67.66  ? 87  VAL A N     1 
ATOM 356  C CA    . VAL A 1 93  ? 115.018 138.430 148.811 1.00 62.21  ? 87  VAL A CA    1 
ATOM 357  C C     . VAL A 1 93  ? 115.321 137.870 147.427 1.00 58.50  ? 87  VAL A C     1 
ATOM 358  O O     . VAL A 1 93  ? 116.486 137.738 147.036 1.00 62.94  ? 87  VAL A O     1 
ATOM 359  C CB    . VAL A 1 93  ? 114.856 137.310 149.854 1.00 71.17  ? 87  VAL A CB    1 
ATOM 360  C CG1   . VAL A 1 93  ? 116.136 136.507 149.974 1.00 69.26  ? 87  VAL A CG1   1 
ATOM 361  C CG2   . VAL A 1 93  ? 114.478 137.895 151.202 1.00 75.34  ? 87  VAL A CG2   1 
ATOM 362  N N     . ALA A 1 197 ? 115.926 145.777 154.433 1.00 80.82  ? 191 ALA A N     1 
ATOM 363  C CA    . ALA A 1 197 ? 114.840 146.569 154.998 1.00 83.96  ? 191 ALA A CA    1 
ATOM 364  C C     . ALA A 1 197 ? 113.628 145.701 155.305 1.00 79.31  ? 191 ALA A C     1 
ATOM 365  O O     . ALA A 1 197 ? 112.999 145.849 156.358 1.00 87.40  ? 191 ALA A O     1 
ATOM 366  C CB    . ALA A 1 197 ? 114.463 147.701 154.045 1.00 85.57  ? 191 ALA A CB    1 
ATOM 367  N N     . ALA A 1 198 ? 113.282 144.793 154.392 1.00 66.23  ? 192 ALA A N     1 
ATOM 368  C CA    . ALA A 1 198 ? 112.190 143.868 154.659 1.00 73.26  ? 192 ALA A CA    1 
ATOM 369  C C     . ALA A 1 198 ? 112.523 142.958 155.832 1.00 75.46  ? 192 ALA A C     1 
ATOM 370  O O     . ALA A 1 198 ? 111.662 142.672 156.672 1.00 79.74  ? 192 ALA A O     1 
ATOM 371  C CB    . ALA A 1 198 ? 111.880 143.044 153.411 1.00 79.52  ? 192 ALA A CB    1 
ATOM 372  N N     . ALA A 1 199 ? 113.771 142.494 155.907 1.00 78.64  ? 193 ALA A N     1 
ATOM 373  C CA    . ALA A 1 199 ? 114.175 141.636 157.013 1.00 81.37  ? 193 ALA A CA    1 
ATOM 374  C C     . ALA A 1 199 ? 114.072 142.368 158.343 1.00 79.60  ? 193 ALA A C     1 
ATOM 375  O O     . ALA A 1 199 ? 113.657 141.787 159.351 1.00 83.51  ? 193 ALA A O     1 
ATOM 376  C CB    . ALA A 1 199 ? 115.598 141.126 156.788 1.00 81.53  ? 193 ALA A CB    1 
ATOM 377  N N     . LEU A 1 200 ? 114.456 143.645 158.367 1.00 78.53  ? 194 LEU A N     1 
ATOM 378  C CA    . LEU A 1 200 ? 114.308 144.435 159.584 1.00 79.50  ? 194 LEU A CA    1 
ATOM 379  C C     . LEU A 1 200 ? 112.843 144.590 159.962 1.00 74.42  ? 194 LEU A C     1 
ATOM 380  O O     . LEU A 1 200 ? 112.484 144.506 161.141 1.00 80.68  ? 194 LEU A O     1 
ATOM 381  C CB    . LEU A 1 200 ? 114.965 145.803 159.405 1.00 81.81  ? 194 LEU A CB    1 
ATOM 382  C CG    . LEU A 1 200 ? 116.390 145.952 159.938 1.00 85.38  ? 194 LEU A CG    1 
ATOM 383  C CD1   . LEU A 1 200 ? 116.881 147.380 159.763 1.00 83.83  ? 194 LEU A CD1   1 
ATOM 384  C CD2   . LEU A 1 200 ? 116.466 145.532 161.399 1.00 80.81  ? 194 LEU A CD2   1 
ATOM 385  N N     . ARG A 1 201 ? 111.981 144.820 158.972 1.00 70.69  ? 195 ARG A N     1 
ATOM 386  C CA    . ARG A 1 201 ? 110.558 144.973 159.253 1.00 76.84  ? 195 ARG A CA    1 
ATOM 387  C C     . ARG A 1 201 ? 109.952 143.670 159.755 1.00 77.80  ? 195 ARG A C     1 
ATOM 388  O O     . ARG A 1 201 ? 109.058 143.683 160.606 1.00 89.33  ? 195 ARG A O     1 
ATOM 389  C CB    . ARG A 1 201 ? 109.828 145.453 158.002 1.00 82.41  ? 195 ARG A CB    1 
ATOM 390  C CG    . ARG A 1 201 ? 108.526 146.186 158.280 1.00 83.43  ? 195 ARG A CG    1 
ATOM 391  C CD    . ARG A 1 201 ? 108.067 147.027 157.093 1.00 81.57  ? 195 ARG A CD    1 
ATOM 392  N NE    . ARG A 1 201 ? 108.459 146.467 155.804 1.00 79.21  ? 195 ARG A NE    1 
ATOM 393  C CZ    . ARG A 1 201 ? 109.482 146.899 155.079 1.00 81.40  ? 195 ARG A CZ    1 
ATOM 394  N NH1   . ARG A 1 201 ? 110.247 147.897 155.488 1.00 82.59  ? 195 ARG A NH1   1 
ATOM 395  N NH2   . ARG A 1 201 ? 109.745 146.313 153.915 1.00 82.11  ? 195 ARG A NH2   1 
ATOM 396  N N     . LEU A 1 202 ? 110.423 142.536 159.232 1.00 72.54  ? 196 LEU A N     1 
ATOM 397  C CA    . LEU A 1 202 ? 109.870 141.249 159.640 1.00 78.71  ? 196 LEU A CA    1 
ATOM 398  C C     . LEU A 1 202 ? 110.147 140.967 161.110 1.00 82.10  ? 196 LEU A C     1 
ATOM 399  O O     . LEU A 1 202 ? 109.287 140.433 161.821 1.00 86.94  ? 196 LEU A O     1 
ATOM 400  C CB    . LEU A 1 202 ? 110.436 140.134 158.764 1.00 81.62  ? 196 LEU A CB    1 
ATOM 401  C CG    . LEU A 1 202 ? 109.584 139.663 157.586 1.00 82.98  ? 196 LEU A CG    1 
ATOM 402  C CD1   . LEU A 1 202 ? 108.477 138.742 158.062 1.00 82.71  ? 196 LEU A CD1   1 
ATOM 403  C CD2   . LEU A 1 202 ? 109.007 140.845 156.850 1.00 81.29  ? 196 LEU A CD2   1 
ATOM 404  N N     . ARG A 1 203 ? 111.344 141.312 161.586 1.00 73.43  ? 197 ARG A N     1 
ATOM 405  C CA    . ARG A 1 203 ? 111.669 141.079 162.988 1.00 72.81  ? 197 ARG A CA    1 
ATOM 406  C C     . ARG A 1 203 ? 110.856 141.978 163.910 1.00 73.57  ? 197 ARG A C     1 
ATOM 407  O O     . ARG A 1 203 ? 110.516 141.571 165.024 1.00 77.58  ? 197 ARG A O     1 
ATOM 408  C CB    . ARG A 1 203 ? 113.161 141.288 163.223 1.00 77.04  ? 197 ARG A CB    1 
ATOM 409  C CG    . ARG A 1 203 ? 113.858 140.091 163.823 1.00 71.25  ? 197 ARG A CG    1 
ATOM 410  C CD    . ARG A 1 203 ? 115.360 140.238 163.731 1.00 71.39  ? 197 ARG A CD    1 
ATOM 411  N NE    . ARG A 1 203 ? 116.047 139.122 164.364 1.00 71.18  ? 197 ARG A NE    1 
ATOM 412  C CZ    . ARG A 1 203 ? 116.568 139.160 165.582 1.00 77.42  ? 197 ARG A CZ    1 
ATOM 413  N NH1   . ARG A 1 203 ? 116.495 140.248 166.329 1.00 78.40  ? 197 ARG A NH1   1 
ATOM 414  N NH2   . ARG A 1 203 ? 117.176 138.080 166.061 1.00 81.67  ? 197 ARG A NH2   1 
ATOM 415  N N     . GLU A 1 204 ? 110.547 143.199 163.470 1.00 75.93  ? 198 GLU A N     1 
ATOM 416  C CA    . GLU A 1 204 ? 109.672 144.062 164.254 1.00 76.30  ? 198 GLU A CA    1 
ATOM 417  C C     . GLU A 1 204 ? 108.294 143.437 164.409 1.00 76.29  ? 198 GLU A C     1 
ATOM 418  O O     . GLU A 1 204 ? 107.666 143.549 165.468 1.00 76.11  ? 198 GLU A O     1 
ATOM 419  C CB    . GLU A 1 204 ? 109.569 145.439 163.602 1.00 80.94  ? 198 GLU A CB    1 
ATOM 420  C CG    . GLU A 1 204 ? 108.935 146.499 164.486 1.00 84.98  ? 198 GLU A CG    1 
ATOM 421  C CD    . GLU A 1 204 ? 109.907 147.069 165.500 1.00 88.80  ? 198 GLU A CD    1 
ATOM 422  O OE1   . GLU A 1 204 ? 110.846 147.782 165.087 1.00 88.84  ? 198 GLU A OE1   1 
ATOM 423  O OE2   . GLU A 1 204 ? 109.732 146.806 166.707 1.00 87.44  ? 198 GLU A OE2   1 
ATOM 424  N N     . ARG A 1 205 ? 107.839 142.731 163.379 1.00 81.82  ? 199 ARG A N     1 
ATOM 425  C CA    . ARG A 1 205 ? 106.560 142.033 163.471 1.00 80.15  ? 199 ARG A CA    1 
ATOM 426  C C     . ARG A 1 205 ? 106.674 140.877 164.451 1.00 86.13  ? 199 ARG A C     1 
ATOM 427  O O     . ARG A 1 205 ? 105.666 140.369 164.940 1.00 92.97  ? 199 ARG A O     1 
ATOM 428  C CB    . ARG A 1 205 ? 106.135 141.524 162.094 1.00 84.45  ? 199 ARG A CB    1 
ATOM 429  C CG    . ARG A 1 205 ? 104.778 140.840 162.066 1.00 87.85  ? 199 ARG A CG    1 
ATOM 430  C CD    . ARG A 1 205 ? 103.677 141.778 162.529 1.00 87.91  ? 199 ARG A CD    1 
ATOM 431  N NE    . ARG A 1 205 ? 103.312 141.544 163.923 1.00 92.37  ? 199 ARG A NE    1 
ATOM 432  C CZ    . ARG A 1 205 ? 103.446 142.444 164.891 1.00 92.45  ? 199 ARG A CZ    1 
ATOM 433  N NH1   . ARG A 1 205 ? 103.939 143.644 164.620 1.00 89.65  ? 199 ARG A NH1   1 
ATOM 434  N NH2   . ARG A 1 205 ? 103.089 142.142 166.132 1.00 91.65  ? 199 ARG A NH2   1 
ATOM 435  N N     . GLY A 1 206 ? 107.900 140.460 164.747 1.00 87.65  ? 200 GLY A N     1 
ATOM 436  C CA    . GLY A 1 206 ? 108.119 139.365 165.667 1.00 90.15  ? 200 GLY A CA    1 
ATOM 437  C C     . GLY A 1 206 ? 107.913 137.988 165.087 1.00 90.41  ? 200 GLY A C     1 
ATOM 438  O O     . GLY A 1 206 ? 107.657 137.047 165.846 1.00 93.62  ? 200 GLY A O     1 
ATOM 439  N N     . VAL A 1 207 ? 108.009 137.837 163.768 1.00 79.91  ? 201 VAL A N     1 
ATOM 440  C CA    . VAL A 1 207 ? 107.812 136.552 163.110 1.00 84.99  ? 201 VAL A CA    1 
ATOM 441  C C     . VAL A 1 207 ? 109.015 136.121 162.289 1.00 76.16  ? 201 VAL A C     1 
ATOM 442  O O     . VAL A 1 207 ? 109.003 135.023 161.728 1.00 79.92  ? 201 VAL A O     1 
ATOM 443  C CB    . VAL A 1 207 ? 106.547 136.562 162.229 1.00 86.00  ? 201 VAL A CB    1 
ATOM 444  C CG1   . VAL A 1 207 ? 105.366 137.144 162.991 1.00 82.99  ? 201 VAL A CG1   1 
ATOM 445  C CG2   . VAL A 1 207 ? 106.798 137.347 160.958 1.00 85.69  ? 201 VAL A CG2   1 
ATOM 446  N N     . PHE A 1 208 ? 110.051 136.943 162.201 1.00 74.67  ? 202 PHE A N     1 
ATOM 447  C CA    . PHE A 1 208 ? 111.167 136.611 161.327 1.00 85.25  ? 202 PHE A CA    1 
ATOM 448  C C     . PHE A 1 208 ? 112.102 135.546 161.891 1.00 87.97  ? 202 PHE A C     1 
ATOM 449  O O     . PHE A 1 208 ? 112.569 134.696 161.122 1.00 91.67  ? 202 PHE A O     1 
ATOM 450  C CB    . PHE A 1 208 ? 111.972 137.860 160.975 1.00 89.89  ? 202 PHE A CB    1 
ATOM 451  C CG    . PHE A 1 208 ? 112.739 137.726 159.692 1.00 87.36  ? 202 PHE A CG    1 
ATOM 452  C CD1   . PHE A 1 208 ? 112.166 137.102 158.598 1.00 76.88  ? 202 PHE A CD1   1 
ATOM 453  C CD2   . PHE A 1 208 ? 114.023 138.224 159.577 1.00 89.27  ? 202 PHE A CD2   1 
ATOM 454  C CE1   . PHE A 1 208 ? 112.855 136.973 157.420 1.00 79.82  ? 202 PHE A CE1   1 
ATOM 455  C CE2   . PHE A 1 208 ? 114.722 138.097 158.395 1.00 90.20  ? 202 PHE A CE2   1 
ATOM 456  C CZ    . PHE A 1 208 ? 114.135 137.471 157.314 1.00 89.68  ? 202 PHE A CZ    1 
ATOM 457  N N     . PRO A 1 209 ? 112.319 135.493 163.215 1.00 65.06  ? 203 PRO A N     1 
ATOM 458  C CA    . PRO A 1 209 ? 113.145 134.366 163.682 1.00 60.38  ? 203 PRO A CA    1 
ATOM 459  C C     . PRO A 1 209 ? 112.462 133.009 163.417 1.00 67.78  ? 203 PRO A C     1 
ATOM 460  O O     . PRO A 1 209 ? 111.277 132.872 163.721 1.00 78.38  ? 203 PRO A O     1 
ATOM 461  C CB    . PRO A 1 209 ? 113.263 134.619 165.185 1.00 59.15  ? 203 PRO A CB    1 
ATOM 462  C CG    . PRO A 1 209 ? 113.071 136.090 165.335 1.00 68.84  ? 203 PRO A CG    1 
ATOM 463  C CD    . PRO A 1 209 ? 112.054 136.460 164.297 1.00 64.60  ? 203 PRO A CD    1 
ATOM 464  N N     . VAL A 1 210 ? 113.188 132.035 162.862 1.00 58.47  ? 204 VAL A N     1 
ATOM 465  C CA    . VAL A 1 210 ? 112.641 130.697 162.568 1.00 62.62  ? 204 VAL A CA    1 
ATOM 466  C C     . VAL A 1 210 ? 113.559 129.583 163.088 1.00 65.17  ? 204 VAL A C     1 
ATOM 467  O O     . VAL A 1 210 ? 114.569 129.881 163.726 1.00 66.10  ? 204 VAL A O     1 
ATOM 468  C CB    . VAL A 1 210 ? 112.412 130.497 161.060 1.00 68.19  ? 204 VAL A CB    1 
ATOM 469  C CG1   . VAL A 1 210 ? 111.439 131.536 160.526 1.00 62.18  ? 204 VAL A CG1   1 
ATOM 470  C CG2   . VAL A 1 210 ? 113.734 130.563 160.311 1.00 70.63  ? 204 VAL A CG2   1 
ATOM 471  N N     . SER A 1 211 ? 113.237 128.309 162.835 1.00 74.41  ? 205 SER A N     1 
ATOM 472  C CA    . SER A 1 211 ? 114.084 127.262 163.399 1.00 76.68  ? 205 SER A CA    1 
ATOM 473  C C     . SER A 1 211 ? 114.776 126.549 162.246 1.00 75.48  ? 205 SER A C     1 
ATOM 474  O O     . SER A 1 211 ? 114.156 125.766 161.524 1.00 77.81  ? 205 SER A O     1 
ATOM 475  C CB    . SER A 1 211 ? 113.260 126.299 164.244 1.00 77.36  ? 205 SER A CB    1 
ATOM 476  O OG    . SER A 1 211 ? 112.134 125.829 163.524 1.00 80.37  ? 205 SER A OG    1 
ATOM 477  N N     . VAL A 1 212 ? 116.056 126.835 162.044 1.00 69.90  ? 206 VAL A N     1 
ATOM 478  C CA    . VAL A 1 212 ? 116.777 126.233 160.926 1.00 67.48  ? 206 VAL A CA    1 
ATOM 479  C C     . VAL A 1 212 ? 116.910 124.727 161.103 1.00 72.98  ? 206 VAL A C     1 
ATOM 480  O O     . VAL A 1 212 ? 117.139 124.247 162.213 1.00 81.30  ? 206 VAL A O     1 
ATOM 481  C CB    . VAL A 1 212 ? 118.174 126.857 160.750 1.00 76.31  ? 206 VAL A CB    1 
ATOM 482  C CG1   . VAL A 1 212 ? 118.051 128.260 160.178 1.00 77.01  ? 206 VAL A CG1   1 
ATOM 483  C CG2   . VAL A 1 212 ? 118.919 126.878 162.075 1.00 76.27  ? 206 VAL A CG2   1 
ATOM 484  N N     . PRO A 1 213 ? 116.765 123.972 160.004 1.00 81.46  ? 207 PRO A N     1 
ATOM 485  C CA    . PRO A 1 213 ? 116.887 122.513 160.074 1.00 83.24  ? 207 PRO A CA    1 
ATOM 486  C C     . PRO A 1 213 ? 118.048 122.116 160.965 1.00 84.67  ? 207 PRO A C     1 
ATOM 487  O O     . PRO A 1 213 ? 117.902 121.215 161.791 1.00 92.10  ? 207 PRO A O     1 
ATOM 488  C CB    . PRO A 1 213 ? 117.176 122.126 158.627 1.00 85.54  ? 207 PRO A CB    1 
ATOM 489  C CG    . PRO A 1 213 ? 116.479 123.172 157.827 1.00 88.00  ? 207 PRO A CG    1 
ATOM 490  C CD    . PRO A 1 213 ? 116.527 124.444 158.629 1.00 88.42  ? 207 PRO A CD    1 
ATOM 491  N N     . GLU A 1 214 ? 119.188 122.775 160.804 1.00 74.09  ? 208 GLU A N     1 
ATOM 492  C CA    . GLU A 1 214 ? 120.337 122.494 161.654 1.00 78.48  ? 208 GLU A CA    1 
ATOM 493  C C     . GLU A 1 214 ? 120.971 123.790 162.116 1.00 83.41  ? 208 GLU A C     1 
ATOM 494  O O     . GLU A 1 214 ? 121.348 124.625 161.295 1.00 89.58  ? 208 GLU A O     1 
ATOM 495  C CB    . GLU A 1 214 ? 121.366 121.643 160.915 1.00 81.06  ? 208 GLU A CB    1 
ATOM 496  C CG    . GLU A 1 214 ? 120.926 120.208 160.687 1.00 86.52  ? 208 GLU A CG    1 
ATOM 497  C CD    . GLU A 1 214 ? 120.041 120.068 159.467 1.00 91.07  ? 208 GLU A CD    1 
ATOM 498  O OE1   . GLU A 1 214 ? 120.101 120.954 158.589 1.00 93.24  ? 208 GLU A OE1   1 
ATOM 499  O OE2   . GLU A 1 214 ? 119.282 119.079 159.390 1.00 90.00  ? 208 GLU A OE2   1 
ATOM 500  N N     . HIS A 1 215 ? 121.078 123.964 163.429 1.00 88.52  ? 209 HIS A N     1 
ATOM 501  C CA    . HIS A 1 215 ? 121.657 125.183 163.982 1.00 87.81  ? 209 HIS A CA    1 
ATOM 502  C C     . HIS A 1 215 ? 122.844 125.668 163.169 1.00 87.93  ? 209 HIS A C     1 
ATOM 503  O O     . HIS A 1 215 ? 123.967 125.206 163.365 1.00 91.71  ? 209 HIS A O     1 
ATOM 504  C CB    . HIS A 1 215 ? 122.087 124.949 165.430 1.00 89.56  ? 209 HIS A CB    1 
ATOM 505  C CG    . HIS A 1 215 ? 122.616 123.573 165.684 1.00 97.75  ? 209 HIS A CG    1 
ATOM 506  N ND1   . HIS A 1 215 ? 121.804 122.517 166.038 1.00 99.24  ? 209 HIS A ND1   1 
ATOM 507  C CD2   . HIS A 1 215 ? 123.875 123.078 165.630 1.00 97.74  ? 209 HIS A CD2   1 
ATOM 508  C CE1   . HIS A 1 215 ? 122.541 121.431 166.194 1.00 94.47  ? 209 HIS A CE1   1 
ATOM 509  N NE2   . HIS A 1 215 ? 123.801 121.745 165.952 1.00 96.03  ? 209 HIS A NE2   1 
ATOM 510  N N     . LEU A 1 216 ? 122.601 126.599 162.256 1.00 78.72  ? 210 LEU A N     1 
ATOM 511  C CA    . LEU A 1 216 ? 123.688 127.155 161.466 1.00 81.63  ? 210 LEU A CA    1 
ATOM 512  C C     . LEU A 1 216 ? 124.175 128.430 162.117 1.00 84.66  ? 210 LEU A C     1 
ATOM 513  O O     . LEU A 1 216 ? 124.863 129.227 161.482 1.00 86.84  ? 210 LEU A O     1 
ATOM 514  C CB    . LEU A 1 216 ? 123.228 127.442 160.041 1.00 80.45  ? 210 LEU A CB    1 
ATOM 515  C CG    . LEU A 1 216 ? 123.160 126.238 159.104 1.00 80.91  ? 210 LEU A CG    1 
ATOM 516  C CD1   . LEU A 1 216 ? 123.392 126.679 157.668 1.00 81.41  ? 210 LEU A CD1   1 
ATOM 517  C CD2   . LEU A 1 216 ? 124.184 125.195 159.520 1.00 81.60  ? 210 LEU A CD2   1 
ATOM 518  N N     . ASP A 1 217 ? 123.825 128.624 163.386 1.00 88.06  ? 211 ASP A N     1 
ATOM 519  C CA    . ASP A 1 217 ? 124.205 129.845 164.081 1.00 85.98  ? 211 ASP A CA    1 
ATOM 520  C C     . ASP A 1 217 ? 123.857 131.028 163.204 1.00 88.50  ? 211 ASP A C     1 
ATOM 521  O O     . ASP A 1 217 ? 122.700 131.442 163.143 1.00 93.84  ? 211 ASP A O     1 
ATOM 522  C CB    . ASP A 1 217 ? 125.697 129.841 164.408 1.00 90.38  ? 211 ASP A CB    1 
ATOM 523  C CG    . ASP A 1 217 ? 126.193 128.477 164.849 1.00 92.87  ? 211 ASP A CG    1 
ATOM 524  O OD1   . ASP A 1 217 ? 126.299 127.573 163.993 1.00 88.42  ? 211 ASP A OD1   1 
ATOM 525  O OD2   . ASP A 1 217 ? 126.478 128.308 166.053 1.00 96.09  ? 211 ASP A OD2   1 
ATOM 526  N N     . LEU A 1 218 ? 124.851 131.573 162.515 1.00 75.83  ? 212 LEU A N     1 
ATOM 527  C CA    . LEU A 1 218 ? 124.596 132.674 161.597 1.00 71.82  ? 212 LEU A CA    1 
ATOM 528  C C     . LEU A 1 218 ? 125.278 132.391 160.273 1.00 73.87  ? 212 LEU A C     1 
ATOM 529  O O     . LEU A 1 218 ? 125.056 131.340 159.683 1.00 81.03  ? 212 LEU A O     1 
ATOM 530  C CB    . LEU A 1 218 ? 125.076 134.010 162.173 1.00 70.97  ? 212 LEU A CB    1 
ATOM 531  C CG    . LEU A 1 218 ? 126.140 134.049 163.275 1.00 72.64  ? 212 LEU A CG    1 
ATOM 532  C CD1   . LEU A 1 218 ? 125.559 133.706 164.639 1.00 79.58  ? 212 LEU A CD1   1 
ATOM 533  C CD2   . LEU A 1 218 ? 127.347 133.182 162.952 1.00 73.87  ? 212 LEU A CD2   1 
ATOM 534  N N     . ASP A 1 219 ? 126.113 133.315 159.815 1.00 75.10  ? 213 ASP A N     1 
ATOM 535  C CA    . ASP A 1 219 ? 126.819 133.155 158.536 1.00 73.68  ? 213 ASP A CA    1 
ATOM 536  C C     . ASP A 1 219 ? 126.291 132.019 157.643 1.00 73.47  ? 213 ASP A C     1 
ATOM 537  O O     . ASP A 1 219 ? 125.542 132.304 156.709 1.00 80.32  ? 213 ASP A O     1 
ATOM 538  C CB    . ASP A 1 219 ? 128.318 133.000 158.773 1.00 81.70  ? 213 ASP A CB    1 
ATOM 539  C CG    . ASP A 1 219 ? 128.917 134.172 159.519 1.00 88.58  ? 213 ASP A CG    1 
ATOM 540  O OD1   . ASP A 1 219 ? 130.161 134.288 159.537 1.00 87.96  ? 213 ASP A OD1   1 
ATOM 541  O OD2   . ASP A 1 219 ? 128.150 134.976 160.089 1.00 90.30  ? 213 ASP A OD2   1 
ATOM 542  N N     . SER A 1 220 ? 126.666 130.755 157.883 1.00 65.08  ? 214 SER A N     1 
ATOM 543  C CA    . SER A 1 220 ? 126.149 129.730 156.990 1.00 64.06  ? 214 SER A CA    1 
ATOM 544  C C     . SER A 1 220 ? 124.696 130.034 156.671 1.00 68.04  ? 214 SER A C     1 
ATOM 545  O O     . SER A 1 220 ? 124.278 129.954 155.514 1.00 80.23  ? 214 SER A O     1 
ATOM 546  C CB    . SER A 1 220 ? 126.282 128.349 157.625 1.00 73.60  ? 214 SER A CB    1 
ATOM 547  O OG    . SER A 1 220 ? 127.627 127.905 157.605 1.00 80.79  ? 214 SER A OG    1 
ATOM 548  N N     . LEU A 1 221 ? 123.928 130.400 157.691 1.00 63.85  ? 215 LEU A N     1 
ATOM 549  C CA    . LEU A 1 221 ? 122.515 130.716 157.500 1.00 62.44  ? 215 LEU A CA    1 
ATOM 550  C C     . LEU A 1 221 ? 122.288 131.768 156.428 1.00 67.99  ? 215 LEU A C     1 
ATOM 551  O O     . LEU A 1 221 ? 121.671 131.491 155.407 1.00 77.10  ? 215 LEU A O     1 
ATOM 552  C CB    . LEU A 1 221 ? 121.914 131.203 158.815 1.00 65.47  ? 215 LEU A CB    1 
ATOM 553  C CG    . LEU A 1 221 ? 120.808 130.313 159.362 1.00 66.45  ? 215 LEU A CG    1 
ATOM 554  C CD1   . LEU A 1 221 ? 119.491 131.072 159.321 1.00 68.39  ? 215 LEU A CD1   1 
ATOM 555  C CD2   . LEU A 1 221 ? 120.742 129.041 158.529 1.00 71.75  ? 215 LEU A CD2   1 
ATOM 556  N N     . LYS A 1 222 ? 122.762 132.983 156.669 1.00 70.24  ? 216 LYS A N     1 
ATOM 557  C CA    . LYS A 1 222 ? 122.609 134.052 155.691 1.00 69.50  ? 216 LYS A CA    1 
ATOM 558  C C     . LYS A 1 222 ? 123.085 133.619 154.313 1.00 74.97  ? 216 LYS A C     1 
ATOM 559  O O     . LYS A 1 222 ? 122.470 133.955 153.306 1.00 85.93  ? 216 LYS A O     1 
ATOM 560  C CB    . LYS A 1 222 ? 123.377 135.295 156.138 1.00 70.56  ? 216 LYS A CB    1 
ATOM 561  C CG    . LYS A 1 222 ? 123.006 135.778 157.530 1.00 72.71  ? 216 LYS A CG    1 
ATOM 562  C CD    . LYS A 1 222 ? 122.261 137.103 157.480 1.00 74.95  ? 216 LYS A CD    1 
ATOM 563  C CE    . LYS A 1 222 ? 121.331 137.179 156.279 1.00 73.08  ? 216 LYS A CE    1 
ATOM 564  N NZ    . LYS A 1 222 ? 120.154 136.278 156.427 1.00 76.82  ? 216 LYS A NZ    1 
ATOM 565  N N     . ALA A 1 223 ? 124.184 132.878 154.264 1.00 63.37  ? 217 ALA A N     1 
ATOM 566  C CA    . ALA A 1 223 ? 124.723 132.423 152.988 1.00 56.11  ? 217 ALA A CA    1 
ATOM 567  C C     . ALA A 1 223 ? 123.710 131.589 152.220 1.00 62.63  ? 217 ALA A C     1 
ATOM 568  O O     . ALA A 1 223 ? 123.363 131.911 151.079 1.00 67.69  ? 217 ALA A O     1 
ATOM 569  C CB    . ALA A 1 223 ? 125.985 131.623 153.223 1.00 55.94  ? 217 ALA A CB    1 
ATOM 570  N N     . ALA A 1 224 ? 123.248 130.506 152.834 1.00 64.41  ? 218 ALA A N     1 
ATOM 571  C CA    . ALA A 1 224 ? 122.242 129.667 152.194 1.00 59.19  ? 218 ALA A CA    1 
ATOM 572  C C     . ALA A 1 224 ? 121.001 130.478 151.834 1.00 64.21  ? 218 ALA A C     1 
ATOM 573  O O     . ALA A 1 224 ? 120.377 130.244 150.804 1.00 76.91  ? 218 ALA A O     1 
ATOM 574  C CB    . ALA A 1 224 ? 121.880 128.495 153.094 1.00 60.66  ? 218 ALA A CB    1 
ATOM 575  N N     . MET A 1 225 ? 120.637 131.434 152.678 1.00 62.14  ? 219 MET A N     1 
ATOM 576  C CA    . MET A 1 225 ? 119.486 132.279 152.382 1.00 65.80  ? 219 MET A CA    1 
ATOM 577  C C     . MET A 1 225 ? 119.688 132.988 151.051 1.00 67.85  ? 219 MET A C     1 
ATOM 578  O O     . MET A 1 225 ? 118.871 132.852 150.137 1.00 77.38  ? 219 MET A O     1 
ATOM 579  C CB    . MET A 1 225 ? 119.263 133.292 153.504 1.00 68.80  ? 219 MET A CB    1 
ATOM 580  C CG    . MET A 1 225 ? 118.425 134.493 153.101 1.00 71.04  ? 219 MET A CG    1 
ATOM 581  S SD    . MET A 1 225 ? 116.848 134.030 152.359 1.00 85.69  ? 219 MET A SD    1 
ATOM 582  C CE    . MET A 1 225 ? 116.059 133.194 153.731 1.00 77.25  ? 219 MET A CE    1 
ATOM 583  N N     . ALA A 1 226 ? 120.774 133.745 150.938 1.00 68.44  ? 220 ALA A N     1 
ATOM 584  C CA    . ALA A 1 226 ? 121.076 134.441 149.689 1.00 69.65  ? 220 ALA A CA    1 
ATOM 585  C C     . ALA A 1 226 ? 121.118 133.476 148.513 1.00 72.04  ? 220 ALA A C     1 
ATOM 586  O O     . ALA A 1 226 ? 120.675 133.812 147.414 1.00 79.72  ? 220 ALA A O     1 
ATOM 587  C CB    . ALA A 1 226 ? 122.395 135.186 149.809 1.00 73.42  ? 220 ALA A CB    1 
ATOM 588  N N     . SER A 1 227 ? 121.661 132.284 148.732 1.00 72.46  ? 221 SER A N     1 
ATOM 589  C CA    . SER A 1 227 ? 121.700 131.283 147.670 1.00 70.72  ? 221 SER A CA    1 
ATOM 590  C C     . SER A 1 227 ? 120.304 130.984 147.165 1.00 68.45  ? 221 SER A C     1 
ATOM 591  O O     . SER A 1 227 ? 120.018 131.160 145.983 1.00 72.69  ? 221 SER A O     1 
ATOM 592  C CB    . SER A 1 227 ? 122.335 129.993 148.169 1.00 72.58  ? 221 SER A CB    1 
ATOM 593  O OG    . SER A 1 227 ? 123.121 130.221 149.322 1.00 70.45  ? 221 SER A OG    1 
ATOM 594  N N     . ALA A 1 228 ? 119.435 130.517 148.055 1.00 77.88  ? 222 ALA A N     1 
ATOM 595  C CA    . ALA A 1 228 ? 118.059 130.230 147.674 1.00 83.35  ? 222 ALA A CA    1 
ATOM 596  C C     . ALA A 1 228 ? 117.457 131.423 146.954 1.00 83.49  ? 222 ALA A C     1 
ATOM 597  O O     . ALA A 1 228 ? 116.758 131.264 145.955 1.00 86.81  ? 222 ALA A O     1 
ATOM 598  C CB    . ALA A 1 228 ? 117.236 129.874 148.899 1.00 83.22  ? 222 ALA A CB    1 
ATOM 599  N N     . ALA A 1 229 ? 117.726 132.621 147.459 1.00 75.90  ? 223 ALA A N     1 
ATOM 600  C CA    . ALA A 1 229 ? 117.228 133.828 146.812 1.00 73.92  ? 223 ALA A CA    1 
ATOM 601  C C     . ALA A 1 229 ? 117.625 133.852 145.346 1.00 80.72  ? 223 ALA A C     1 
ATOM 602  O O     . ALA A 1 229 ? 116.772 133.740 144.459 1.00 85.92  ? 223 ALA A O     1 
ATOM 603  C CB    . ALA A 1 229 ? 117.766 135.055 147.519 1.00 73.69  ? 223 ALA A CB    1 
ATOM 604  N N     . GLU A 1 230 ? 118.919 134.004 145.086 1.00 85.14  ? 224 GLU A N     1 
ATOM 605  C CA    . GLU A 1 230 ? 119.404 134.016 143.711 1.00 80.51  ? 224 GLU A CA    1 
ATOM 606  C C     . GLU A 1 230 ? 118.740 132.914 142.897 1.00 83.45  ? 224 GLU A C     1 
ATOM 607  O O     . GLU A 1 230 ? 118.285 133.152 141.783 1.00 87.81  ? 224 GLU A O     1 
ATOM 608  C CB    . GLU A 1 230 ? 120.926 133.863 143.683 1.00 85.13  ? 224 GLU A CB    1 
ATOM 609  C CG    . GLU A 1 230 ? 121.440 132.855 142.669 1.00 89.33  ? 224 GLU A CG    1 
ATOM 610  C CD    . GLU A 1 230 ? 122.699 132.154 143.135 1.00 93.33  ? 224 GLU A CD    1 
ATOM 611  O OE1   . GLU A 1 230 ? 122.753 131.751 144.316 1.00 93.91  ? 224 GLU A OE1   1 
ATOM 612  O OE2   . GLU A 1 230 ? 123.635 132.007 142.321 1.00 91.81  ? 224 GLU A OE2   1 
ATOM 613  N N     . ARG A 1 231 ? 118.678 131.711 143.460 1.00 77.23  ? 225 ARG A N     1 
ATOM 614  C CA    . ARG A 1 231 ? 118.077 130.585 142.752 1.00 71.91  ? 225 ARG A CA    1 
ATOM 615  C C     . ARG A 1 231 ? 116.825 131.007 141.992 1.00 74.53  ? 225 ARG A C     1 
ATOM 616  O O     . ARG A 1 231 ? 116.740 130.834 140.777 1.00 82.16  ? 225 ARG A O     1 
ATOM 617  C CB    . ARG A 1 231 ? 117.740 129.459 143.731 1.00 77.40  ? 225 ARG A CB    1 
ATOM 618  C CG    . ARG A 1 231 ? 117.859 128.066 143.140 1.00 80.00  ? 225 ARG A CG    1 
ATOM 619  C CD    . ARG A 1 231 ? 119.092 127.353 143.668 1.00 76.42  ? 225 ARG A CD    1 
ATOM 620  N NE    . ARG A 1 231 ? 119.309 126.074 143.000 1.00 78.29  ? 225 ARG A NE    1 
ATOM 621  C CZ    . ARG A 1 231 ? 120.157 125.893 141.992 1.00 82.80  ? 225 ARG A CZ    1 
ATOM 622  N NH1   . ARG A 1 231 ? 120.871 126.911 141.533 1.00 81.90  ? 225 ARG A NH1   1 
ATOM 623  N NH2   . ARG A 1 231 ? 120.291 124.693 141.446 1.00 85.62  ? 225 ARG A NH2   1 
ATOM 624  N N     . LYS A 1 354 ? 123.572 127.053 146.334 1.00 35.74  ? 348 LYS A N     1 
ATOM 625  C CA    . LYS A 1 354 ? 124.994 127.191 146.619 1.00 33.96  ? 348 LYS A CA    1 
ATOM 626  C C     . LYS A 1 354 ? 125.155 127.711 148.040 1.00 36.68  ? 348 LYS A C     1 
ATOM 627  O O     . LYS A 1 354 ? 124.925 128.894 148.304 1.00 48.28  ? 348 LYS A O     1 
ATOM 628  C CB    . LYS A 1 354 ? 125.653 128.130 145.612 1.00 27.06  ? 348 LYS A CB    1 
ATOM 629  C CG    . LYS A 1 354 ? 126.291 127.429 144.430 1.00 25.54  ? 348 LYS A CG    1 
ATOM 630  C CD    . LYS A 1 354 ? 126.046 128.194 143.143 1.00 31.26  ? 348 LYS A CD    1 
ATOM 631  C CE    . LYS A 1 354 ? 127.251 129.039 142.768 1.00 33.31  ? 348 LYS A CE    1 
ATOM 632  N NZ    . LYS A 1 354 ? 127.145 129.581 141.385 1.00 32.92  ? 348 LYS A NZ    1 
ATOM 633  N N     . VAL A 1 355 ? 125.548 126.832 148.961 1.00 30.90  ? 349 VAL A N     1 
ATOM 634  C CA    . VAL A 1 355 ? 125.826 127.257 150.325 1.00 32.51  ? 349 VAL A CA    1 
ATOM 635  C C     . VAL A 1 355 ? 127.131 128.039 150.290 1.00 43.40  ? 349 VAL A C     1 
ATOM 636  O O     . VAL A 1 355 ? 128.218 127.456 150.202 1.00 47.38  ? 349 VAL A O     1 
ATOM 637  C CB    . VAL A 1 355 ? 125.900 126.063 151.292 1.00 33.84  ? 349 VAL A CB    1 
ATOM 638  C CG1   . VAL A 1 355 ? 126.394 126.511 152.656 1.00 38.95  ? 349 VAL A CG1   1 
ATOM 639  C CG2   . VAL A 1 355 ? 124.538 125.403 151.413 1.00 37.35  ? 349 VAL A CG2   1 
ATOM 640  N N     . ARG A 1 356 ? 127.027 129.360 150.351 1.00 40.83  ? 350 ARG A N     1 
ATOM 641  C CA    . ARG A 1 356 ? 128.152 130.238 150.076 1.00 25.46  ? 350 ARG A CA    1 
ATOM 642  C C     . ARG A 1 356 ? 128.941 130.542 151.342 1.00 36.31  ? 350 ARG A C     1 
ATOM 643  O O     . ARG A 1 356 ? 128.410 130.516 152.454 1.00 45.20  ? 350 ARG A O     1 
ATOM 644  C CB    . ARG A 1 356 ? 127.669 131.541 149.439 1.00 26.59  ? 350 ARG A CB    1 
ATOM 645  C CG    . ARG A 1 356 ? 127.629 131.504 147.924 1.00 31.34  ? 350 ARG A CG    1 
ATOM 646  C CD    . ARG A 1 356 ? 126.307 132.031 147.392 1.00 40.47  ? 350 ARG A CD    1 
ATOM 647  N NE    . ARG A 1 356 ? 126.167 133.467 147.603 1.00 42.97  ? 350 ARG A NE    1 
ATOM 648  C CZ    . ARG A 1 356 ? 125.156 134.194 147.149 1.00 43.99  ? 350 ARG A CZ    1 
ATOM 649  N NH1   . ARG A 1 356 ? 124.173 133.651 146.447 1.00 37.68  ? 350 ARG A NH1   1 
ATOM 650  N NH2   . ARG A 1 356 ? 125.130 135.499 147.401 1.00 43.07  ? 350 ARG A NH2   1 
ATOM 651  N N     . PHE A 1 357 ? 130.227 130.834 151.154 1.00 29.73  ? 351 PHE A N     1 
ATOM 652  C CA    . PHE A 1 357 ? 131.137 131.193 152.238 1.00 30.66  ? 351 PHE A CA    1 
ATOM 653  C C     . PHE A 1 357 ? 131.831 132.494 151.843 1.00 37.07  ? 351 PHE A C     1 
ATOM 654  O O     . PHE A 1 357 ? 132.761 132.487 151.033 1.00 34.08  ? 351 PHE A O     1 
ATOM 655  C CB    . PHE A 1 357 ? 132.146 130.082 152.504 1.00 25.61  ? 351 PHE A CB    1 
ATOM 656  C CG    . PHE A 1 357 ? 131.525 128.794 152.962 1.00 36.06  ? 351 PHE A CG    1 
ATOM 657  C CD1   . PHE A 1 357 ? 130.930 128.703 154.206 1.00 40.67  ? 351 PHE A CD1   1 
ATOM 658  C CD2   . PHE A 1 357 ? 131.540 127.675 152.150 1.00 39.39  ? 351 PHE A CD2   1 
ATOM 659  C CE1   . PHE A 1 357 ? 130.357 127.521 154.632 1.00 36.84  ? 351 PHE A CE1   1 
ATOM 660  C CE2   . PHE A 1 357 ? 130.972 126.492 152.568 1.00 40.67  ? 351 PHE A CE2   1 
ATOM 661  C CZ    . PHE A 1 357 ? 130.379 126.415 153.811 1.00 37.46  ? 351 PHE A CZ    1 
ATOM 662  N N     . GLY A 1 358 ? 131.380 133.608 152.416 1.00 38.71  ? 352 GLY A N     1 
ATOM 663  C CA    . GLY A 1 358 ? 131.945 134.896 152.090 1.00 39.58  ? 352 GLY A CA    1 
ATOM 664  C C     . GLY A 1 358 ? 133.054 135.319 153.036 1.00 38.09  ? 352 GLY A C     1 
ATOM 665  O O     . GLY A 1 358 ? 133.185 134.809 154.146 1.00 37.83  ? 352 GLY A O     1 
ATOM 666  N N     . LEU A 1 359 ? 133.859 136.273 152.578 1.00 30.11  ? 353 LEU A N     1 
ATOM 667  C CA    . LEU A 1 359 ? 134.982 136.785 153.349 1.00 26.94  ? 353 LEU A CA    1 
ATOM 668  C C     . LEU A 1 359 ? 134.678 138.117 154.022 1.00 30.10  ? 353 LEU A C     1 
ATOM 669  O O     . LEU A 1 359 ? 135.588 138.736 154.581 1.00 40.31  ? 353 LEU A O     1 
ATOM 670  C CB    . LEU A 1 359 ? 136.213 136.926 152.454 1.00 24.01  ? 353 LEU A CB    1 
ATOM 671  C CG    . LEU A 1 359 ? 137.041 135.661 152.241 1.00 27.21  ? 353 LEU A CG    1 
ATOM 672  C CD1   . LEU A 1 359 ? 137.810 135.742 150.939 1.00 31.06  ? 353 LEU A CD1   1 
ATOM 673  C CD2   . LEU A 1 359 ? 137.983 135.438 153.408 1.00 32.94  ? 353 LEU A CD2   1 
ATOM 674  N N     . THR A 1 360 ? 133.427 138.573 153.982 1.00 36.06  ? 354 THR A N     1 
ATOM 675  C CA    . THR A 1 360 ? 133.067 139.843 154.596 1.00 41.71  ? 354 THR A CA    1 
ATOM 676  C C     . THR A 1 360 ? 131.786 139.793 155.414 1.00 46.54  ? 354 THR A C     1 
ATOM 677  O O     . THR A 1 360 ? 131.372 140.835 155.933 1.00 46.08  ? 354 THR A O     1 
ATOM 678  C CB    . THR A 1 360 ? 132.923 140.937 153.530 1.00 33.84  ? 354 THR A CB    1 
ATOM 679  O OG1   . THR A 1 360 ? 132.044 140.483 152.495 1.00 39.28  ? 354 THR A OG1   1 
ATOM 680  C CG2   . THR A 1 360 ? 134.271 141.303 152.930 1.00 40.12  ? 354 THR A CG2   1 
ATOM 681  N N     . GLY A 1 363 ? 128.863 134.704 154.560 1.00 44.20  ? 357 GLY A N     1 
ATOM 682  C CA    . GLY A 1 363 ? 128.859 133.394 155.174 1.00 40.20  ? 357 GLY A CA    1 
ATOM 683  C C     . GLY A 1 363 ? 130.052 133.217 156.086 1.00 47.33  ? 357 GLY A C     1 
ATOM 684  O O     . GLY A 1 363 ? 130.741 134.190 156.404 1.00 53.81  ? 357 GLY A O     1 
ATOM 685  N N     . ARG A 1 364 ? 130.308 131.988 156.522 1.00 49.29  ? 358 ARG A N     1 
ATOM 686  C CA    . ARG A 1 364 ? 131.503 131.724 157.305 1.00 47.89  ? 358 ARG A CA    1 
ATOM 687  C C     . ARG A 1 364 ? 132.741 131.937 156.445 1.00 43.74  ? 358 ARG A C     1 
ATOM 688  O O     . ARG A 1 364 ? 132.784 131.528 155.282 1.00 48.79  ? 358 ARG A O     1 
ATOM 689  C CB    . ARG A 1 364 ? 131.477 130.301 157.857 1.00 52.34  ? 358 ARG A CB    1 
ATOM 690  C CG    . ARG A 1 364 ? 130.145 129.893 158.463 1.00 48.39  ? 358 ARG A CG    1 
ATOM 691  C CD    . ARG A 1 364 ? 129.850 130.677 159.727 1.00 46.33  ? 358 ARG A CD    1 
ATOM 692  N NE    . ARG A 1 364 ? 130.986 130.689 160.639 1.00 50.29  ? 358 ARG A NE    1 
ATOM 693  C CZ    . ARG A 1 364 ? 131.102 131.504 161.678 1.00 55.40  ? 358 ARG A CZ    1 
ATOM 694  N NH1   . ARG A 1 364 ? 130.160 132.383 161.975 1.00 53.81  ? 358 ARG A NH1   1 
ATOM 695  N NH2   . ARG A 1 364 ? 132.190 131.433 162.440 1.00 57.20  ? 358 ARG A NH2   1 
ATOM 696  N N     . LYS A 1 365 ? 133.746 132.590 157.018 1.00 38.29  ? 359 LYS A N     1 
ATOM 697  C CA    . LYS A 1 365 ? 134.958 132.890 156.272 1.00 39.48  ? 359 LYS A CA    1 
ATOM 698  C C     . LYS A 1 365 ? 135.695 131.608 155.906 1.00 39.16  ? 359 LYS A C     1 
ATOM 699  O O     . LYS A 1 365 ? 135.631 130.602 156.617 1.00 46.56  ? 359 LYS A O     1 
ATOM 700  C CB    . LYS A 1 365 ? 135.873 133.803 157.085 1.00 41.56  ? 359 LYS A CB    1 
ATOM 701  C CG    . LYS A 1 365 ? 135.153 134.946 157.770 1.00 43.16  ? 359 LYS A CG    1 
ATOM 702  C CD    . LYS A 1 365 ? 135.933 136.241 157.643 1.00 41.82  ? 359 LYS A CD    1 
ATOM 703  C CE    . LYS A 1 365 ? 135.325 137.332 158.506 1.00 47.91  ? 359 LYS A CE    1 
ATOM 704  N NZ    . LYS A 1 365 ? 133.840 137.366 158.392 1.00 48.24  ? 359 LYS A NZ    1 
ATOM 705  N N     . PHE A 1 366 ? 136.397 131.649 154.778 1.00 26.99  ? 360 PHE A N     1 
ATOM 706  C CA    . PHE A 1 366 ? 137.189 130.521 154.319 1.00 24.71  ? 360 PHE A CA    1 
ATOM 707  C C     . PHE A 1 366 ? 138.605 130.989 154.024 1.00 35.29  ? 360 PHE A C     1 
ATOM 708  O O     . PHE A 1 366 ? 138.856 132.176 153.802 1.00 50.39  ? 360 PHE A O     1 
ATOM 709  C CB    . PHE A 1 366 ? 136.576 129.865 153.076 1.00 25.48  ? 360 PHE A CB    1 
ATOM 710  C CG    . PHE A 1 366 ? 136.689 130.692 151.830 1.00 23.33  ? 360 PHE A CG    1 
ATOM 711  C CD1   . PHE A 1 366 ? 135.820 131.744 151.597 1.00 31.10  ? 360 PHE A CD1   1 
ATOM 712  C CD2   . PHE A 1 366 ? 137.657 130.411 150.883 1.00 29.07  ? 360 PHE A CD2   1 
ATOM 713  C CE1   . PHE A 1 366 ? 135.922 132.503 150.451 1.00 34.63  ? 360 PHE A CE1   1 
ATOM 714  C CE2   . PHE A 1 366 ? 137.762 131.167 149.735 1.00 29.27  ? 360 PHE A CE2   1 
ATOM 715  C CZ    . PHE A 1 366 ? 136.893 132.213 149.521 1.00 31.47  ? 360 PHE A CZ    1 
ATOM 716  N N     . VAL A 1 367 ? 139.535 130.038 154.032 1.00 33.48  ? 361 VAL A N     1 
ATOM 717  C CA    . VAL A 1 367 ? 140.941 130.295 153.741 1.00 30.50  ? 361 VAL A CA    1 
ATOM 718  C C     . VAL A 1 367 ? 141.340 129.326 152.637 1.00 34.46  ? 361 VAL A C     1 
ATOM 719  O O     . VAL A 1 367 ? 141.661 128.164 152.906 1.00 42.02  ? 361 VAL A O     1 
ATOM 720  C CB    . VAL A 1 367 ? 141.839 130.130 154.971 1.00 33.52  ? 361 VAL A CB    1 
ATOM 721  C CG1   . VAL A 1 367 ? 143.271 130.498 154.629 1.00 33.86  ? 361 VAL A CG1   1 
ATOM 722  C CG2   . VAL A 1 367 ? 141.330 130.985 156.116 1.00 40.45  ? 361 VAL A CG2   1 
ATOM 723  N N     . LEU A 1 368 ? 141.319 129.797 151.396 1.00 33.30  ? 362 LEU A N     1 
ATOM 724  C CA    . LEU A 1 368 ? 141.682 128.978 150.248 1.00 32.54  ? 362 LEU A CA    1 
ATOM 725  C C     . LEU A 1 368 ? 143.184 129.071 150.019 1.00 36.12  ? 362 LEU A C     1 
ATOM 726  O O     . LEU A 1 368 ? 143.702 130.143 149.689 1.00 42.90  ? 362 LEU A O     1 
ATOM 727  C CB    . LEU A 1 368 ? 140.918 129.431 149.005 1.00 32.58  ? 362 LEU A CB    1 
ATOM 728  C CG    . LEU A 1 368 ? 141.297 128.771 147.679 1.00 26.64  ? 362 LEU A CG    1 
ATOM 729  C CD1   . LEU A 1 368 ? 140.365 127.618 147.371 1.00 33.97  ? 362 LEU A CD1   1 
ATOM 730  C CD2   . LEU A 1 368 ? 141.280 129.788 146.554 1.00 32.87  ? 362 LEU A CD2   1 
ATOM 731  N N     . SER A 1 369 ? 143.881 127.957 150.200 1.00 35.87  ? 363 SER A N     1 
ATOM 732  C CA    . SER A 1 369 ? 145.310 127.862 149.934 1.00 39.30  ? 363 SER A CA    1 
ATOM 733  C C     . SER A 1 369 ? 145.543 126.816 148.850 1.00 43.08  ? 363 SER A C     1 
ATOM 734  O O     . SER A 1 369 ? 144.604 126.221 148.325 1.00 45.63  ? 363 SER A O     1 
ATOM 735  C CB    . SER A 1 369 ? 146.083 127.518 151.209 1.00 42.52  ? 363 SER A CB    1 
ATOM 736  O OG    . SER A 1 369 ? 147.478 127.519 150.970 1.00 51.95  ? 363 SER A OG    1 
ATOM 737  N N     . ALA A 1 370 ? 146.811 126.576 148.528 1.00 49.35  ? 364 ALA A N     1 
ATOM 738  C CA    . ALA A 1 370 ? 147.154 125.596 147.507 1.00 54.92  ? 364 ALA A CA    1 
ATOM 739  C C     . ALA A 1 370 ? 148.437 124.879 147.887 1.00 53.99  ? 364 ALA A C     1 
ATOM 740  O O     . ALA A 1 370 ? 149.419 125.519 148.274 1.00 55.81  ? 364 ALA A O     1 
ATOM 741  C CB    . ALA A 1 370 ? 147.312 126.255 146.133 1.00 54.56  ? 364 ALA A CB    1 
ATOM 742  N N     . ALA A 1 371 ? 148.424 123.556 147.768 1.00 52.95  ? 365 ALA A N     1 
ATOM 743  C CA    . ALA A 1 371 ? 149.608 122.739 147.992 1.00 50.26  ? 365 ALA A CA    1 
ATOM 744  C C     . ALA A 1 371 ? 149.792 121.798 146.816 1.00 52.08  ? 365 ALA A C     1 
ATOM 745  O O     . ALA A 1 371 ? 148.822 121.220 146.314 1.00 57.18  ? 365 ALA A O     1 
ATOM 746  C CB    . ALA A 1 371 ? 149.503 121.937 149.291 1.00 52.54  ? 365 ALA A CB    1 
ATOM 747  N N     . GLY A 1 372 ? 151.038 121.646 146.378 1.00 53.21  ? 366 GLY A N     1 
ATOM 748  C CA    . GLY A 1 372 ? 151.334 120.793 145.246 1.00 57.25  ? 366 GLY A CA    1 
ATOM 749  C C     . GLY A 1 372 ? 150.597 121.223 143.997 1.00 58.40  ? 366 GLY A C     1 
ATOM 750  O O     . GLY A 1 372 ? 150.941 122.232 143.375 1.00 61.82  ? 366 GLY A O     1 
ATOM 751  N N     . SER A 1 373 ? 149.576 120.455 143.618 1.00 49.48  ? 367 SER A N     1 
ATOM 752  C CA    . SER A 1 373 ? 148.743 120.769 142.464 1.00 53.21  ? 367 SER A CA    1 
ATOM 753  C C     . SER A 1 373 ? 147.266 120.758 142.833 1.00 52.44  ? 367 SER A C     1 
ATOM 754  O O     . SER A 1 373 ? 146.412 120.485 141.985 1.00 62.61  ? 367 SER A O     1 
ATOM 755  C CB    . SER A 1 373 ? 149.012 119.798 141.318 1.00 55.17  ? 367 SER A CB    1 
ATOM 756  O OG    . SER A 1 373 ? 148.403 118.542 141.566 1.00 56.70  ? 367 SER A OG    1 
ATOM 757  N N     . ARG A 1 374 ? 146.944 121.050 144.092 1.00 45.10  ? 368 ARG A N     1 
ATOM 758  C CA    . ARG A 1 374 ? 145.567 120.995 144.554 1.00 47.09  ? 368 ARG A CA    1 
ATOM 759  C C     . ARG A 1 374 ? 145.293 122.150 145.504 1.00 52.10  ? 368 ARG A C     1 
ATOM 760  O O     . ARG A 1 374 ? 146.211 122.787 146.028 1.00 52.19  ? 368 ARG A O     1 
ATOM 761  C CB    . ARG A 1 374 ? 145.257 119.656 145.237 1.00 48.38  ? 368 ARG A CB    1 
ATOM 762  C CG    . ARG A 1 374 ? 145.962 119.456 146.564 1.00 48.37  ? 368 ARG A CG    1 
ATOM 763  C CD    . ARG A 1 374 ? 146.441 118.024 146.720 1.00 50.35  ? 368 ARG A CD    1 
ATOM 764  N NE    . ARG A 1 374 ? 145.332 117.092 146.865 1.00 50.09  ? 368 ARG A NE    1 
ATOM 765  C CZ    . ARG A 1 374 ? 145.278 115.895 146.294 1.00 56.30  ? 368 ARG A CZ    1 
ATOM 766  N NH1   . ARG A 1 374 ? 146.259 115.453 145.526 1.00 54.38  ? 368 ARG A NH1   1 
ATOM 767  N NH2   . ARG A 1 374 ? 144.213 115.126 146.499 1.00 55.65  ? 368 ARG A NH2   1 
ATOM 768  N N     . PHE A 1 375 ? 144.008 122.419 145.706 1.00 45.33  ? 369 PHE A N     1 
ATOM 769  C CA    . PHE A 1 375 ? 143.546 123.467 146.601 1.00 35.20  ? 369 PHE A CA    1 
ATOM 770  C C     . PHE A 1 375 ? 143.318 122.919 148.007 1.00 43.54  ? 369 PHE A C     1 
ATOM 771  O O     . PHE A 1 375 ? 143.313 121.709 148.241 1.00 49.08  ? 369 PHE A O     1 
ATOM 772  C CB    . PHE A 1 375 ? 142.262 124.100 146.064 1.00 30.76  ? 369 PHE A CB    1 
ATOM 773  C CG    . PHE A 1 375 ? 142.492 125.161 145.027 1.00 33.59  ? 369 PHE A CG    1 
ATOM 774  C CD1   . PHE A 1 375 ? 143.607 125.975 145.088 1.00 40.50  ? 369 PHE A CD1   1 
ATOM 775  C CD2   . PHE A 1 375 ? 141.591 125.345 143.995 1.00 33.81  ? 369 PHE A CD2   1 
ATOM 776  C CE1   . PHE A 1 375 ? 143.817 126.956 144.140 1.00 37.89  ? 369 PHE A CE1   1 
ATOM 777  C CE2   . PHE A 1 375 ? 141.800 126.322 143.042 1.00 35.72  ? 369 PHE A CE2   1 
ATOM 778  C CZ    . PHE A 1 375 ? 142.914 127.126 143.114 1.00 32.49  ? 369 PHE A CZ    1 
ATOM 779  N N     . LEU A 1 376 ? 143.126 123.840 148.950 1.00 41.78  ? 370 LEU A N     1 
ATOM 780  C CA    . LEU A 1 376 ? 142.835 123.491 150.341 1.00 34.87  ? 370 LEU A CA    1 
ATOM 781  C C     . LEU A 1 376 ? 141.888 124.560 150.880 1.00 39.68  ? 370 LEU A C     1 
ATOM 782  O O     . LEU A 1 376 ? 142.316 125.685 151.157 1.00 56.46  ? 370 LEU A O     1 
ATOM 783  C CB    . LEU A 1 376 ? 144.104 123.407 151.178 1.00 37.26  ? 370 LEU A CB    1 
ATOM 784  C CG    . LEU A 1 376 ? 145.016 122.197 150.991 1.00 46.26  ? 370 LEU A CG    1 
ATOM 785  C CD1   . LEU A 1 376 ? 146.465 122.630 151.063 1.00 41.15  ? 370 LEU A CD1   1 
ATOM 786  C CD2   . LEU A 1 376 ? 144.717 121.138 152.038 1.00 47.02  ? 370 LEU A CD2   1 
ATOM 787  N N     . ILE A 1 377 ? 140.617 124.205 151.019 1.00 30.12  ? 371 ILE A N     1 
ATOM 788  C CA    . ILE A 1 377 ? 139.597 125.113 151.526 1.00 36.70  ? 371 ILE A CA    1 
ATOM 789  C C     . ILE A 1 377 ? 139.422 124.859 153.014 1.00 41.35  ? 371 ILE A C     1 
ATOM 790  O O     . ILE A 1 377 ? 139.250 123.709 153.440 1.00 44.76  ? 371 ILE A O     1 
ATOM 791  C CB    . ILE A 1 377 ? 138.269 124.934 150.771 1.00 36.71  ? 371 ILE A CB    1 
ATOM 792  C CG1   . ILE A 1 377 ? 138.500 125.046 149.264 1.00 35.15  ? 371 ILE A CG1   1 
ATOM 793  C CG2   . ILE A 1 377 ? 137.254 125.966 151.227 1.00 41.11  ? 371 ILE A CG2   1 
ATOM 794  C CD1   . ILE A 1 377 ? 138.459 123.723 148.538 1.00 39.45  ? 371 ILE A CD1   1 
ATOM 795  N N     . THR A 1 378 ? 139.467 125.925 153.807 1.00 46.64  ? 372 THR A N     1 
ATOM 796  C CA    . THR A 1 378 ? 139.359 125.847 155.262 1.00 46.56  ? 372 THR A CA    1 
ATOM 797  C C     . THR A 1 378 ? 138.149 126.669 155.692 1.00 46.28  ? 372 THR A C     1 
ATOM 798  O O     . THR A 1 378 ? 138.269 127.857 156.000 1.00 55.08  ? 372 THR A O     1 
ATOM 799  C CB    . THR A 1 378 ? 140.635 126.347 155.938 1.00 46.42  ? 372 THR A CB    1 
ATOM 800  O OG1   . THR A 1 378 ? 141.778 125.759 155.303 1.00 45.43  ? 372 THR A OG1   1 
ATOM 801  C CG2   . THR A 1 378 ? 140.634 125.986 157.411 1.00 40.95  ? 372 THR A CG2   1 
ATOM 802  N N     . VAL A 1 379 ? 136.980 126.030 155.719 1.00 46.07  ? 373 VAL A N     1 
ATOM 803  C CA    . VAL A 1 379 ? 135.766 126.710 156.146 1.00 48.33  ? 373 VAL A CA    1 
ATOM 804  C C     . VAL A 1 379 ? 135.801 126.906 157.654 1.00 52.97  ? 373 VAL A C     1 
ATOM 805  O O     . VAL A 1 379 ? 136.064 125.964 158.413 1.00 58.94  ? 373 VAL A O     1 
ATOM 806  C CB    . VAL A 1 379 ? 134.526 125.918 155.713 1.00 44.75  ? 373 VAL A CB    1 
ATOM 807  C CG1   . VAL A 1 379 ? 133.277 126.507 156.337 1.00 48.78  ? 373 VAL A CG1   1 
ATOM 808  C CG2   . VAL A 1 379 ? 134.414 125.903 154.200 1.00 46.94  ? 373 VAL A CG2   1 
ATOM 809  N N     . LYS A 1 380 ? 135.536 128.135 158.099 1.00 47.33  ? 374 LYS A N     1 
ATOM 810  C CA    . LYS A 1 380 ? 135.614 128.487 159.516 1.00 47.66  ? 374 LYS A CA    1 
ATOM 811  C C     . LYS A 1 380 ? 134.220 128.367 160.128 1.00 50.62  ? 374 LYS A C     1 
ATOM 812  O O     . LYS A 1 380 ? 133.517 129.353 160.350 1.00 54.45  ? 374 LYS A O     1 
ATOM 813  C CB    . LYS A 1 380 ? 136.191 129.887 159.688 1.00 52.46  ? 374 LYS A CB    1 
ATOM 814  C CG    . LYS A 1 380 ? 137.692 129.966 159.476 1.00 54.69  ? 374 LYS A CG    1 
ATOM 815  C CD    . LYS A 1 380 ? 138.135 131.395 159.223 1.00 53.00  ? 374 LYS A CD    1 
ATOM 816  C CE    . LYS A 1 380 ? 139.558 131.624 159.698 1.00 49.96  ? 374 LYS A CE    1 
ATOM 817  N NZ    . LYS A 1 380 ? 140.322 130.351 159.779 1.00 54.86  ? 374 LYS A NZ    1 
ATOM 818  N N     . LEU A 1 381 ? 133.826 127.128 160.404 1.00 52.79  ? 375 LEU A N     1 
ATOM 819  C CA    . LEU A 1 381 ? 132.546 126.872 161.039 1.00 51.33  ? 375 LEU A CA    1 
ATOM 820  C C     . LEU A 1 381 ? 132.595 127.287 162.508 1.00 57.44  ? 375 LEU A C     1 
ATOM 821  O O     . LEU A 1 381 ? 133.670 127.340 163.111 1.00 58.49  ? 375 LEU A O     1 
ATOM 822  C CB    . LEU A 1 381 ? 132.182 125.396 160.916 1.00 51.75  ? 375 LEU A CB    1 
ATOM 823  C CG    . LEU A 1 381 ? 131.554 124.955 159.593 1.00 55.25  ? 375 LEU A CG    1 
ATOM 824  C CD1   . LEU A 1 381 ? 130.767 123.672 159.777 1.00 59.01  ? 375 LEU A CD1   1 
ATOM 825  C CD2   . LEU A 1 381 ? 130.666 126.047 159.025 1.00 52.67  ? 375 LEU A CD2   1 
ATOM 826  N N     . PRO A 1 382 ? 131.442 127.606 163.103 1.00 64.83  ? 376 PRO A N     1 
ATOM 827  C CA    . PRO A 1 382 ? 131.438 127.972 164.530 1.00 62.03  ? 376 PRO A CA    1 
ATOM 828  C C     . PRO A 1 382 ? 131.966 126.874 165.434 1.00 67.16  ? 376 PRO A C     1 
ATOM 829  O O     . PRO A 1 382 ? 132.602 127.175 166.452 1.00 69.29  ? 376 PRO A O     1 
ATOM 830  C CB    . PRO A 1 382 ? 129.960 128.275 164.812 1.00 61.97  ? 376 PRO A CB    1 
ATOM 831  C CG    . PRO A 1 382 ? 129.368 128.576 163.483 1.00 66.04  ? 376 PRO A CG    1 
ATOM 832  C CD    . PRO A 1 382 ? 130.101 127.713 162.505 1.00 67.24  ? 376 PRO A CD    1 
ATOM 833  N N     . CYS A 1 383 ? 131.713 125.606 165.099 1.00 71.42  ? 377 CYS A N     1 
ATOM 834  C CA    . CYS A 1 383 ? 132.249 124.509 165.899 1.00 73.19  ? 377 CYS A CA    1 
ATOM 835  C C     . CYS A 1 383 ? 133.771 124.474 165.842 1.00 74.72  ? 377 CYS A C     1 
ATOM 836  O O     . CYS A 1 383 ? 134.434 124.262 166.863 1.00 73.00  ? 377 CYS A O     1 
ATOM 837  C CB    . CYS A 1 383 ? 131.663 123.183 165.421 1.00 75.36  ? 377 CYS A CB    1 
ATOM 838  S SG    . CYS A 1 383 ? 129.984 123.307 164.765 1.00 85.63  ? 377 CYS A SG    1 
ATOM 839  N N     . GLY A 1 384 ? 134.338 124.679 164.661 1.00 72.41  ? 378 GLY A N     1 
ATOM 840  C CA    . GLY A 1 384 ? 135.777 124.660 164.508 1.00 64.67  ? 378 GLY A CA    1 
ATOM 841  C C     . GLY A 1 384 ? 136.156 124.799 163.050 1.00 68.65  ? 378 GLY A C     1 
ATOM 842  O O     . GLY A 1 384 ? 135.308 124.999 162.177 1.00 70.88  ? 378 GLY A O     1 
ATOM 843  N N     . ASP A 1 385 ? 137.459 124.686 162.806 1.00 65.53  ? 379 ASP A N     1 
ATOM 844  C CA    . ASP A 1 385 ? 137.988 124.788 161.453 1.00 63.12  ? 379 ASP A CA    1 
ATOM 845  C C     . ASP A 1 385 ? 137.856 123.451 160.736 1.00 60.89  ? 379 ASP A C     1 
ATOM 846  O O     . ASP A 1 385 ? 138.197 122.402 161.290 1.00 65.63  ? 379 ASP A O     1 
ATOM 847  C CB    . ASP A 1 385 ? 139.448 125.234 161.482 1.00 64.55  ? 379 ASP A CB    1 
ATOM 848  C CG    . ASP A 1 385 ? 139.596 126.740 161.466 1.00 65.46  ? 379 ASP A CG    1 
ATOM 849  O OD1   . ASP A 1 385 ? 138.622 127.438 161.818 1.00 66.43  ? 379 ASP A OD1   1 
ATOM 850  O OD2   . ASP A 1 385 ? 140.688 127.227 161.101 1.00 63.80  ? 379 ASP A OD2   1 
ATOM 851  N N     . VAL A 1 386 ? 137.365 123.492 159.504 1.00 53.25  ? 380 VAL A N     1 
ATOM 852  C CA    . VAL A 1 386 ? 137.159 122.304 158.688 1.00 55.37  ? 380 VAL A CA    1 
ATOM 853  C C     . VAL A 1 386 ? 138.141 122.385 157.526 1.00 59.85  ? 380 VAL A C     1 
ATOM 854  O O     . VAL A 1 386 ? 137.890 123.074 156.532 1.00 62.19  ? 380 VAL A O     1 
ATOM 855  C CB    . VAL A 1 386 ? 135.714 122.192 158.194 1.00 60.64  ? 380 VAL A CB    1 
ATOM 856  C CG1   . VAL A 1 386 ? 135.463 120.821 157.602 1.00 58.24  ? 380 VAL A CG1   1 
ATOM 857  C CG2   . VAL A 1 386 ? 134.744 122.475 159.329 1.00 57.31  ? 380 VAL A CG2   1 
ATOM 858  N N     . GLY A 1 387 ? 139.262 121.679 157.645 1.00 58.56  ? 381 GLY A N     1 
ATOM 859  C CA    . GLY A 1 387 ? 140.250 121.664 156.585 1.00 59.92  ? 381 GLY A CA    1 
ATOM 860  C C     . GLY A 1 387 ? 139.937 120.634 155.520 1.00 58.41  ? 381 GLY A C     1 
ATOM 861  O O     . GLY A 1 387 ? 140.072 119.432 155.754 1.00 62.09  ? 381 GLY A O     1 
ATOM 862  N N     . LEU A 1 388 ? 139.519 121.096 154.344 1.00 52.13  ? 382 LEU A N     1 
ATOM 863  C CA    . LEU A 1 388 ? 139.107 120.220 153.252 1.00 49.76  ? 382 LEU A CA    1 
ATOM 864  C C     . LEU A 1 388 ? 140.123 120.329 152.123 1.00 49.13  ? 382 LEU A C     1 
ATOM 865  O O     . LEU A 1 388 ? 140.335 121.416 151.575 1.00 65.02  ? 382 LEU A O     1 
ATOM 866  C CB    . LEU A 1 388 ? 137.711 120.590 152.757 1.00 50.31  ? 382 LEU A CB    1 
ATOM 867  C CG    . LEU A 1 388 ? 136.588 120.582 153.789 1.00 50.31  ? 382 LEU A CG    1 
ATOM 868  C CD1   . LEU A 1 388 ? 135.833 121.895 153.754 1.00 51.39  ? 382 LEU A CD1   1 
ATOM 869  C CD2   . LEU A 1 388 ? 135.654 119.419 153.528 1.00 53.24  ? 382 LEU A CD2   1 
ATOM 870  N N     . THR A 1 389 ? 140.748 119.210 151.782 1.00 38.57  ? 383 THR A N     1 
ATOM 871  C CA    . THR A 1 389 ? 141.578 119.153 150.591 1.00 46.45  ? 383 THR A CA    1 
ATOM 872  C C     . THR A 1 389 ? 140.725 118.777 149.386 1.00 46.44  ? 383 THR A C     1 
ATOM 873  O O     . THR A 1 389 ? 139.764 118.012 149.494 1.00 49.79  ? 383 THR A O     1 
ATOM 874  C CB    . THR A 1 389 ? 142.717 118.148 150.768 1.00 55.65  ? 383 THR A CB    1 
ATOM 875  O OG1   . THR A 1 389 ? 143.333 117.892 149.500 1.00 56.51  ? 383 THR A OG1   1 
ATOM 876  C CG2   . THR A 1 389 ? 142.194 116.843 151.347 1.00 52.40  ? 383 THR A CG2   1 
ATOM 877  N N     . ALA A 1 390 ? 141.086 119.324 148.231 1.00 35.80  ? 384 ALA A N     1 
ATOM 878  C CA    . ALA A 1 390 ? 140.312 119.144 147.013 1.00 34.99  ? 384 ALA A CA    1 
ATOM 879  C C     . ALA A 1 390 ? 141.059 118.251 146.034 1.00 42.11  ? 384 ALA A C     1 
ATOM 880  O O     . ALA A 1 390 ? 142.293 118.246 145.987 1.00 48.92  ? 384 ALA A O     1 
ATOM 881  C CB    . ALA A 1 390 ? 140.002 120.489 146.355 1.00 38.21  ? 384 ALA A CB    1 
ATOM 882  N N     . VAL A 1 391 ? 140.295 117.488 145.260 1.00 35.14  ? 385 VAL A N     1 
ATOM 883  C CA    . VAL A 1 391 ? 140.888 116.620 144.238 1.00 36.65  ? 385 VAL A CA    1 
ATOM 884  C C     . VAL A 1 391 ? 141.594 117.483 143.199 1.00 39.76  ? 385 VAL A C     1 
ATOM 885  O O     . VAL A 1 391 ? 141.017 118.488 142.738 1.00 37.34  ? 385 VAL A O     1 
ATOM 886  C CB    . VAL A 1 391 ? 139.804 115.743 143.585 1.00 40.18  ? 385 VAL A CB    1 
ATOM 887  C CG1   . VAL A 1 391 ? 140.404 114.832 142.533 1.00 41.86  ? 385 VAL A CG1   1 
ATOM 888  C CG2   . VAL A 1 391 ? 139.080 114.928 144.640 1.00 34.34  ? 385 VAL A CG2   1 
ATOM 889  N N     . PRO A 1 392 ? 142.827 117.163 142.809 1.00 41.56  ? 386 PRO A N     1 
ATOM 890  C CA    . PRO A 1 392 ? 143.561 118.035 141.875 1.00 41.57  ? 386 PRO A CA    1 
ATOM 891  C C     . PRO A 1 392 ? 142.848 118.153 140.537 1.00 42.12  ? 386 PRO A C     1 
ATOM 892  O O     . PRO A 1 392 ? 142.709 117.178 139.796 1.00 52.48  ? 386 PRO A O     1 
ATOM 893  C CB    . PRO A 1 392 ? 144.918 117.337 141.736 1.00 38.97  ? 386 PRO A CB    1 
ATOM 894  C CG    . PRO A 1 392 ? 144.675 115.929 142.163 1.00 39.67  ? 386 PRO A CG    1 
ATOM 895  C CD    . PRO A 1 392 ? 143.638 116.013 143.235 1.00 38.19  ? 386 PRO A CD    1 
ATOM 896  N N     . SER A 1 393 ? 142.403 119.365 140.232 1.00 35.82  ? 387 SER A N     1 
ATOM 897  C CA    . SER A 1 393 ? 141.725 119.658 138.982 1.00 31.76  ? 387 SER A CA    1 
ATOM 898  C C     . SER A 1 393 ? 142.734 120.020 137.902 1.00 30.87  ? 387 SER A C     1 
ATOM 899  O O     . SER A 1 393 ? 143.794 120.585 138.180 1.00 35.27  ? 387 SER A O     1 
ATOM 900  C CB    . SER A 1 393 ? 140.728 120.804 139.168 1.00 23.01  ? 387 SER A CB    1 
ATOM 901  O OG    . SER A 1 393 ? 140.251 121.280 137.926 1.00 25.71  ? 387 SER A OG    1 
ATOM 902  N N     . ARG A 1 394 ? 142.401 119.674 136.661 1.00 26.81  ? 388 ARG A N     1 
ATOM 903  C CA    . ARG A 1 394 ? 143.210 120.076 135.520 1.00 27.40  ? 388 ARG A CA    1 
ATOM 904  C C     . ARG A 1 394 ? 142.873 121.477 135.035 1.00 37.55  ? 388 ARG A C     1 
ATOM 905  O O     . ARG A 1 394 ? 143.613 122.026 134.213 1.00 40.48  ? 388 ARG A O     1 
ATOM 906  C CB    . ARG A 1 394 ? 143.043 119.079 134.369 1.00 28.88  ? 388 ARG A CB    1 
ATOM 907  C CG    . ARG A 1 394 ? 143.973 117.881 134.448 1.00 36.01  ? 388 ARG A CG    1 
ATOM 908  C CD    . ARG A 1 394 ? 145.425 118.302 134.344 1.00 36.56  ? 388 ARG A CD    1 
ATOM 909  N NE    . ARG A 1 394 ? 146.246 117.281 133.704 1.00 36.37  ? 388 ARG A NE    1 
ATOM 910  C CZ    . ARG A 1 394 ? 147.293 117.540 132.931 1.00 41.51  ? 388 ARG A CZ    1 
ATOM 911  N NH1   . ARG A 1 394 ? 147.679 118.780 132.683 1.00 37.79  ? 388 ARG A NH1   1 
ATOM 912  N NH2   . ARG A 1 394 ? 147.969 116.527 132.396 1.00 38.44  ? 388 ARG A NH2   1 
ATOM 913  N N     . TYR A 1 395 ? 141.776 122.061 135.519 1.00 42.55  ? 389 TYR A N     1 
ATOM 914  C CA    . TYR A 1 395 ? 141.481 123.461 135.238 1.00 21.99  ? 389 TYR A CA    1 
ATOM 915  C C     . TYR A 1 395 ? 142.390 124.373 136.053 1.00 34.29  ? 389 TYR A C     1 
ATOM 916  O O     . TYR A 1 395 ? 143.169 125.154 135.497 1.00 47.32  ? 389 TYR A O     1 
ATOM 917  C CB    . TYR A 1 395 ? 140.006 123.746 135.539 1.00 18.20  ? 389 TYR A CB    1 
ATOM 918  C CG    . TYR A 1 395 ? 139.513 125.101 135.083 1.00 21.36  ? 389 TYR A CG    1 
ATOM 919  C CD1   . TYR A 1 395 ? 139.818 126.251 135.794 1.00 34.02  ? 389 TYR A CD1   1 
ATOM 920  C CD2   . TYR A 1 395 ? 138.731 125.227 133.946 1.00 34.13  ? 389 TYR A CD2   1 
ATOM 921  C CE1   . TYR A 1 395 ? 139.367 127.485 135.382 1.00 34.79  ? 389 TYR A CE1   1 
ATOM 922  C CE2   . TYR A 1 395 ? 138.276 126.456 133.527 1.00 29.48  ? 389 TYR A CE2   1 
ATOM 923  C CZ    . TYR A 1 395 ? 138.595 127.582 134.250 1.00 34.81  ? 389 TYR A CZ    1 
ATOM 924  O OH    . TYR A 1 395 ? 138.145 128.813 133.839 1.00 48.10  ? 389 TYR A OH    1 
ATOM 925  N N     . PHE A 1 396 ? 142.307 124.279 137.377 1.00 27.99  ? 390 PHE A N     1 
ATOM 926  C CA    . PHE A 1 396 ? 143.195 125.024 138.270 1.00 8.67   ? 390 PHE A CA    1 
ATOM 927  C C     . PHE A 1 396 ? 144.488 124.242 138.496 1.00 21.60  ? 390 PHE A C     1 
ATOM 928  O O     . PHE A 1 396 ? 144.844 123.873 139.613 1.00 31.95  ? 390 PHE A O     1 
ATOM 929  C CB    . PHE A 1 396 ? 142.494 125.317 139.591 1.00 17.02  ? 390 PHE A CB    1 
ATOM 930  C CG    . PHE A 1 396 ? 141.149 125.962 139.443 1.00 12.21  ? 390 PHE A CG    1 
ATOM 931  C CD1   . PHE A 1 396 ? 141.037 127.269 139.015 1.00 17.96  ? 390 PHE A CD1   1 
ATOM 932  C CD2   . PHE A 1 396 ? 139.998 125.267 139.749 1.00 28.06  ? 390 PHE A CD2   1 
ATOM 933  C CE1   . PHE A 1 396 ? 139.803 127.864 138.886 1.00 27.18  ? 390 PHE A CE1   1 
ATOM 934  C CE2   . PHE A 1 396 ? 138.761 125.858 139.621 1.00 22.74  ? 390 PHE A CE2   1 
ATOM 935  C CZ    . PHE A 1 396 ? 138.664 127.158 139.188 1.00 10.15  ? 390 PHE A CZ    1 
ATOM 936  N N     . TRP A 1 397 ? 145.194 123.987 137.400 1.00 32.76  ? 391 TRP A N     1 
ATOM 937  C CA    . TRP A 1 397 ? 146.400 123.175 137.456 1.00 38.70  ? 391 TRP A CA    1 
ATOM 938  C C     . TRP A 1 397 ? 147.576 123.990 137.981 1.00 35.51  ? 391 TRP A C     1 
ATOM 939  O O     . TRP A 1 397 ? 147.789 125.134 137.572 1.00 35.59  ? 391 TRP A O     1 
ATOM 940  C CB    . TRP A 1 397 ? 146.734 122.614 136.076 1.00 36.88  ? 391 TRP A CB    1 
ATOM 941  C CG    . TRP A 1 397 ? 147.873 121.647 136.089 1.00 43.38  ? 391 TRP A CG    1 
ATOM 942  C CD1   . TRP A 1 397 ? 149.114 121.839 135.560 1.00 43.12  ? 391 TRP A CD1   1 
ATOM 943  C CD2   . TRP A 1 397 ? 147.878 120.337 136.664 1.00 44.55  ? 391 TRP A CD2   1 
ATOM 944  N NE1   . TRP A 1 397 ? 149.894 120.727 135.768 1.00 40.36  ? 391 TRP A NE1   1 
ATOM 945  C CE2   . TRP A 1 397 ? 149.156 119.791 136.444 1.00 46.91  ? 391 TRP A CE2   1 
ATOM 946  C CE3   . TRP A 1 397 ? 146.924 119.574 137.342 1.00 41.14  ? 391 TRP A CE3   1 
ATOM 947  C CZ2   . TRP A 1 397 ? 149.506 118.515 136.878 1.00 44.12  ? 391 TRP A CZ2   1 
ATOM 948  C CZ3   . TRP A 1 397 ? 147.273 118.307 137.770 1.00 42.68  ? 391 TRP A CZ3   1 
ATOM 949  C CH2   . TRP A 1 397 ? 148.552 117.791 137.538 1.00 41.32  ? 391 TRP A CH2   1 
ATOM 950  N N     . ASN A 1 398 ? 148.341 123.381 138.883 1.00 35.85  ? 392 ASN A N     1 
ATOM 951  C CA    . ASN A 1 398 ? 149.499 124.008 139.509 1.00 37.50  ? 392 ASN A CA    1 
ATOM 952  C C     . ASN A 1 398 ? 149.173 125.404 140.048 1.00 38.34  ? 392 ASN A C     1 
ATOM 953  O O     . ASN A 1 398 ? 149.782 126.394 139.633 1.00 45.38  ? 392 ASN A O     1 
ATOM 954  C CB    . ASN A 1 398 ? 150.669 124.069 138.536 1.00 38.99  ? 392 ASN A CB    1 
ATOM 955  C CG    . ASN A 1 398 ? 151.792 123.130 138.918 1.00 44.24  ? 392 ASN A CG    1 
ATOM 956  O OD1   . ASN A 1 398 ? 151.576 122.133 139.610 1.00 47.86  ? 392 ASN A OD1   1 
ATOM 957  N ND2   . ASN A 1 398 ? 153.002 123.440 138.469 1.00 44.10  ? 392 ASN A ND2   1 
ATOM 958  N N     . PRO A 1 399 ? 148.219 125.516 140.967 1.00 35.71  ? 393 PRO A N     1 
ATOM 959  C CA    . PRO A 1 399 ? 147.765 126.839 141.391 1.00 36.36  ? 393 PRO A CA    1 
ATOM 960  C C     . PRO A 1 399 ? 148.624 127.424 142.497 1.00 42.19  ? 393 PRO A C     1 
ATOM 961  O O     . PRO A 1 399 ? 149.209 126.712 143.318 1.00 44.31  ? 393 PRO A O     1 
ATOM 962  C CB    . PRO A 1 399 ? 146.343 126.567 141.888 1.00 31.13  ? 393 PRO A CB    1 
ATOM 963  C CG    . PRO A 1 399 ? 146.413 125.177 142.423 1.00 39.16  ? 393 PRO A CG    1 
ATOM 964  C CD    . PRO A 1 399 ? 147.505 124.443 141.681 1.00 42.54  ? 393 PRO A CD    1 
ATOM 965  N N     . SER A 1 400 ? 148.694 128.752 142.504 1.00 45.72  ? 394 SER A N     1 
ATOM 966  C CA    . SER A 1 400 ? 149.364 129.510 143.553 1.00 41.17  ? 394 SER A CA    1 
ATOM 967  C C     . SER A 1 400 ? 148.385 130.549 144.075 1.00 44.72  ? 394 SER A C     1 
ATOM 968  O O     . SER A 1 400 ? 147.828 131.325 143.291 1.00 46.48  ? 394 SER A O     1 
ATOM 969  C CB    . SER A 1 400 ? 150.637 130.176 143.026 1.00 41.73  ? 394 SER A CB    1 
ATOM 970  O OG    . SER A 1 400 ? 151.236 130.991 144.019 1.00 51.40  ? 394 SER A OG    1 
ATOM 971  N N     . VAL A 1 401 ? 148.173 130.566 145.387 1.00 39.85  ? 395 VAL A N     1 
ATOM 972  C CA    . VAL A 1 401 ? 147.201 131.447 146.020 1.00 38.38  ? 395 VAL A CA    1 
ATOM 973  C C     . VAL A 1 401 ? 147.920 132.335 147.023 1.00 41.76  ? 395 VAL A C     1 
ATOM 974  O O     . VAL A 1 401 ? 148.721 131.850 147.828 1.00 52.06  ? 395 VAL A O     1 
ATOM 975  C CB    . VAL A 1 401 ? 146.075 130.657 146.711 1.00 42.08  ? 395 VAL A CB    1 
ATOM 976  C CG1   . VAL A 1 401 ? 144.855 131.535 146.896 1.00 41.72  ? 395 VAL A CG1   1 
ATOM 977  C CG2   . VAL A 1 401 ? 145.717 129.433 145.899 1.00 44.45  ? 395 VAL A CG2   1 
ATOM 978  N N     . GLY A 1 402 ? 147.631 133.631 146.967 1.00 49.31  ? 396 GLY A N     1 
ATOM 979  C CA    . GLY A 1 402 ? 148.155 134.575 147.933 1.00 54.34  ? 396 GLY A CA    1 
ATOM 980  C C     . GLY A 1 402 ? 147.106 135.581 148.348 1.00 58.35  ? 396 GLY A C     1 
ATOM 981  O O     . GLY A 1 402 ? 146.532 136.272 147.501 1.00 58.92  ? 396 GLY A O     1 
ATOM 982  N N     . ARG A 1 403 ? 146.841 135.672 149.649 1.00 61.58  ? 397 ARG A N     1 
ATOM 983  C CA    . ARG A 1 403 ? 145.809 136.574 150.140 1.00 61.03  ? 397 ARG A CA    1 
ATOM 984  C C     . ARG A 1 403 ? 146.192 138.024 149.881 1.00 67.83  ? 397 ARG A C     1 
ATOM 985  O O     . ARG A 1 403 ? 147.339 138.429 150.090 1.00 66.99  ? 397 ARG A O     1 
ATOM 986  C CB    . ARG A 1 403 ? 145.577 136.351 151.634 1.00 62.75  ? 397 ARG A CB    1 
ATOM 987  C CG    . ARG A 1 403 ? 144.473 137.209 152.224 1.00 62.64  ? 397 ARG A CG    1 
ATOM 988  C CD    . ARG A 1 403 ? 143.784 136.503 153.378 1.00 67.26  ? 397 ARG A CD    1 
ATOM 989  N NE    . ARG A 1 403 ? 144.616 135.447 153.943 1.00 65.81  ? 397 ARG A NE    1 
ATOM 990  C CZ    . ARG A 1 403 ? 144.215 134.597 154.879 1.00 66.17  ? 397 ARG A CZ    1 
ATOM 991  N NH1   . ARG A 1 403 ? 142.996 134.655 155.389 1.00 66.52  ? 397 ARG A NH1   1 
ATOM 992  N NH2   . ARG A 1 403 ? 145.058 133.667 155.314 1.00 65.88  ? 397 ARG A NH2   1 
ATOM 993  N N     . THR A 1 404 ? 145.223 138.807 149.419 1.00 64.24  ? 398 THR A N     1 
ATOM 994  C CA    . THR A 1 404 ? 145.418 140.220 149.150 1.00 62.49  ? 398 THR A CA    1 
ATOM 995  C C     . THR A 1 404 ? 144.870 141.052 150.307 1.00 63.18  ? 398 THR A C     1 
ATOM 996  O O     . THR A 1 404 ? 144.272 140.538 151.255 1.00 67.16  ? 398 THR A O     1 
ATOM 997  C CB    . THR A 1 404 ? 144.752 140.615 147.831 1.00 61.28  ? 398 THR A CB    1 
ATOM 998  O OG1   . THR A 1 404 ? 143.333 140.484 147.951 1.00 60.85  ? 398 THR A OG1   1 
ATOM 999  C CG2   . THR A 1 404 ? 145.244 139.729 146.701 1.00 61.50  ? 398 THR A CG2   1 
ATOM 1000 N N     . THR A 1 405 ? 145.080 142.362 150.223 1.00 65.02  ? 399 THR A N     1 
ATOM 1001 C CA    . THR A 1 405 ? 144.584 143.289 151.230 1.00 65.87  ? 399 THR A CA    1 
ATOM 1002 C C     . THR A 1 405 ? 143.147 143.721 150.978 1.00 63.17  ? 399 THR A C     1 
ATOM 1003 O O     . THR A 1 405 ? 142.601 144.496 151.770 1.00 63.67  ? 399 THR A O     1 
ATOM 1004 C CB    . THR A 1 405 ? 145.486 144.524 151.299 1.00 67.02  ? 399 THR A CB    1 
ATOM 1005 O OG1   . THR A 1 405 ? 145.098 145.458 150.285 1.00 68.67  ? 399 THR A OG1   1 
ATOM 1006 C CG2   . THR A 1 405 ? 146.940 144.131 151.088 1.00 61.87  ? 399 THR A CG2   1 
ATOM 1007 N N     . SER A 1 406 ? 142.523 143.242 149.903 1.00 55.91  ? 400 SER A N     1 
ATOM 1008 C CA    . SER A 1 406 ? 141.161 143.616 149.545 1.00 58.86  ? 400 SER A CA    1 
ATOM 1009 C C     . SER A 1 406 ? 140.164 142.504 149.856 1.00 60.50  ? 400 SER A C     1 
ATOM 1010 O O     . SER A 1 406 ? 139.130 142.393 149.192 1.00 61.37  ? 400 SER A O     1 
ATOM 1011 C CB    . SER A 1 406 ? 141.085 143.998 148.070 1.00 59.85  ? 400 SER A CB    1 
ATOM 1012 O OG    . SER A 1 406 ? 142.115 144.909 147.729 1.00 66.99  ? 400 SER A OG    1 
ATOM 1013 N N     . ASN A 1 407 ? 140.461 141.679 150.861 1.00 53.72  ? 401 ASN A N     1 
ATOM 1014 C CA    . ASN A 1 407 ? 139.597 140.571 151.272 1.00 46.82  ? 401 ASN A CA    1 
ATOM 1015 C C     . ASN A 1 407 ? 139.330 139.627 150.096 1.00 47.85  ? 401 ASN A C     1 
ATOM 1016 O O     . ASN A 1 407 ? 138.191 139.426 149.669 1.00 49.47  ? 401 ASN A O     1 
ATOM 1017 C CB    . ASN A 1 407 ? 138.287 141.092 151.871 1.00 50.79  ? 401 ASN A CB    1 
ATOM 1018 C CG    . ASN A 1 407 ? 138.437 141.527 153.311 1.00 56.51  ? 401 ASN A CG    1 
ATOM 1019 O OD1   . ASN A 1 407 ? 137.451 141.835 153.982 1.00 57.78  ? 401 ASN A OD1   1 
ATOM 1020 N ND2   . ASN A 1 407 ? 139.671 141.556 153.797 1.00 57.74  ? 401 ASN A ND2   1 
ATOM 1021 N N     . SER A 1 408 ? 140.409 139.051 149.579 1.00 42.52  ? 402 SER A N     1 
ATOM 1022 C CA    . SER A 1 408 ? 140.330 138.249 148.367 1.00 35.63  ? 402 SER A CA    1 
ATOM 1023 C C     . SER A 1 408 ? 141.525 137.310 148.327 1.00 46.00  ? 402 SER A C     1 
ATOM 1024 O O     . SER A 1 408 ? 142.469 137.440 149.108 1.00 52.61  ? 402 SER A O     1 
ATOM 1025 C CB    . SER A 1 408 ? 140.301 139.135 147.120 1.00 47.49  ? 402 SER A CB    1 
ATOM 1026 O OG    . SER A 1 408 ? 139.135 139.931 147.084 1.00 57.24  ? 402 SER A OG    1 
ATOM 1027 N N     . PHE A 1 409 ? 141.472 136.359 147.399 1.00 35.32  ? 403 PHE A N     1 
ATOM 1028 C CA    . PHE A 1 409 ? 142.590 135.466 147.131 1.00 32.39  ? 403 PHE A CA    1 
ATOM 1029 C C     . PHE A 1 409 ? 142.964 135.571 145.661 1.00 38.83  ? 403 PHE A C     1 
ATOM 1030 O O     . PHE A 1 409 ? 142.089 135.535 144.792 1.00 51.54  ? 403 PHE A O     1 
ATOM 1031 C CB    . PHE A 1 409 ? 142.243 134.021 147.498 1.00 31.50  ? 403 PHE A CB    1 
ATOM 1032 C CG    . PHE A 1 409 ? 142.049 133.804 148.971 1.00 44.57  ? 403 PHE A CG    1 
ATOM 1033 C CD1   . PHE A 1 409 ? 143.135 133.576 149.797 1.00 43.82  ? 403 PHE A CD1   1 
ATOM 1034 C CD2   . PHE A 1 409 ? 140.786 133.833 149.528 1.00 42.17  ? 403 PHE A CD2   1 
ATOM 1035 C CE1   . PHE A 1 409 ? 142.961 133.378 151.150 1.00 34.19  ? 403 PHE A CE1   1 
ATOM 1036 C CE2   . PHE A 1 409 ? 140.609 133.635 150.881 1.00 34.37  ? 403 PHE A CE2   1 
ATOM 1037 C CZ    . PHE A 1 409 ? 141.697 133.409 151.692 1.00 32.09  ? 403 PHE A CZ    1 
ATOM 1038 N N     . ARG A 1 410 ? 144.255 135.708 145.383 1.00 44.64  ? 404 ARG A N     1 
ATOM 1039 C CA    . ARG A 1 410 ? 144.751 135.860 144.018 1.00 41.80  ? 404 ARG A CA    1 
ATOM 1040 C C     . ARG A 1 410 ? 145.263 134.505 143.542 1.00 40.80  ? 404 ARG A C     1 
ATOM 1041 O O     . ARG A 1 410 ? 146.366 134.086 143.897 1.00 49.52  ? 404 ARG A O     1 
ATOM 1042 C CB    . ARG A 1 410 ? 145.843 136.921 143.949 1.00 40.50  ? 404 ARG A CB    1 
ATOM 1043 C CG    . ARG A 1 410 ? 145.855 137.709 142.653 1.00 40.70  ? 404 ARG A CG    1 
ATOM 1044 C CD    . ARG A 1 410 ? 147.209 138.347 142.418 1.00 45.94  ? 404 ARG A CD    1 
ATOM 1045 N NE    . ARG A 1 410 ? 148.129 137.434 141.750 1.00 51.30  ? 404 ARG A NE    1 
ATOM 1046 C CZ    . ARG A 1 410 ? 148.606 137.615 140.527 1.00 50.96  ? 404 ARG A CZ    1 
ATOM 1047 N NH1   . ARG A 1 410 ? 148.279 138.675 139.807 1.00 48.55  ? 404 ARG A NH1   1 
ATOM 1048 N NH2   . ARG A 1 410 ? 149.434 136.710 140.014 1.00 45.26  ? 404 ARG A NH2   1 
ATOM 1049 N N     . ILE A 1 411 ? 144.464 133.828 142.730 1.00 30.42  ? 405 ILE A N     1 
ATOM 1050 C CA    . ILE A 1 411 ? 144.804 132.503 142.228 1.00 28.92  ? 405 ILE A CA    1 
ATOM 1051 C C     . ILE A 1 411 ? 145.498 132.639 140.881 1.00 38.84  ? 405 ILE A C     1 
ATOM 1052 O O     . ILE A 1 411 ? 145.107 133.452 140.037 1.00 38.78  ? 405 ILE A O     1 
ATOM 1053 C CB    . ILE A 1 411 ? 143.550 131.615 142.128 1.00 31.45  ? 405 ILE A CB    1 
ATOM 1054 C CG1   . ILE A 1 411 ? 142.485 132.281 141.256 1.00 33.37  ? 405 ILE A CG1   1 
ATOM 1055 C CG2   . ILE A 1 411 ? 142.993 131.335 143.509 1.00 35.30  ? 405 ILE A CG2   1 
ATOM 1056 C CD1   . ILE A 1 411 ? 141.337 131.367 140.894 1.00 35.29  ? 405 ILE A CD1   1 
ATOM 1057 N N     . GLU A 1 412 ? 146.545 131.841 140.687 1.00 46.98  ? 406 GLU A N     1 
ATOM 1058 C CA    . GLU A 1 412 ? 147.332 131.831 139.457 1.00 44.68  ? 406 GLU A CA    1 
ATOM 1059 C C     . GLU A 1 412 ? 147.506 130.381 139.033 1.00 37.58  ? 406 GLU A C     1 
ATOM 1060 O O     . GLU A 1 412 ? 148.211 129.619 139.700 1.00 47.70  ? 406 GLU A O     1 
ATOM 1061 C CB    . GLU A 1 412 ? 148.683 132.512 139.666 1.00 44.76  ? 406 GLU A CB    1 
ATOM 1062 C CG    . GLU A 1 412 ? 149.479 132.730 138.397 1.00 48.66  ? 406 GLU A CG    1 
ATOM 1063 C CD    . GLU A 1 412 ? 150.880 133.234 138.681 1.00 58.63  ? 406 GLU A CD    1 
ATOM 1064 O OE1   . GLU A 1 412 ? 151.032 134.092 139.575 1.00 54.65  ? 406 GLU A OE1   1 
ATOM 1065 O OE2   . GLU A 1 412 ? 151.829 132.773 138.012 1.00 59.07  ? 406 GLU A OE2   1 
ATOM 1066 N N     . PHE A 1 413 ? 146.878 130.000 137.925 1.00 29.79  ? 407 PHE A N     1 
ATOM 1067 C CA    . PHE A 1 413 ? 146.801 128.597 137.539 1.00 31.53  ? 407 PHE A CA    1 
ATOM 1068 C C     . PHE A 1 413 ? 147.103 128.467 136.050 1.00 36.06  ? 407 PHE A C     1 
ATOM 1069 O O     . PHE A 1 413 ? 147.571 129.410 135.404 1.00 49.38  ? 407 PHE A O     1 
ATOM 1070 C CB    . PHE A 1 413 ? 145.431 128.013 137.908 1.00 38.02  ? 407 PHE A CB    1 
ATOM 1071 C CG    . PHE A 1 413 ? 144.268 128.801 137.377 1.00 35.58  ? 407 PHE A CG    1 
ATOM 1072 C CD1   . PHE A 1 413 ? 143.694 129.805 138.131 1.00 25.59  ? 407 PHE A CD1   1 
ATOM 1073 C CD2   . PHE A 1 413 ? 143.739 128.523 136.129 1.00 32.28  ? 407 PHE A CD2   1 
ATOM 1074 C CE1   . PHE A 1 413 ? 142.621 130.522 137.647 1.00 25.07  ? 407 PHE A CE1   1 
ATOM 1075 C CE2   . PHE A 1 413 ? 142.667 129.238 135.643 1.00 23.39  ? 407 PHE A CE2   1 
ATOM 1076 C CZ    . PHE A 1 413 ? 142.109 130.238 136.402 1.00 26.82  ? 407 PHE A CZ    1 
ATOM 1077 N N     . THR A 1 414 ? 146.843 127.278 135.510 1.00 29.13  ? 408 THR A N     1 
ATOM 1078 C CA    . THR A 1 414 ? 147.084 126.969 134.104 1.00 27.84  ? 408 THR A CA    1 
ATOM 1079 C C     . THR A 1 414 ? 145.926 126.124 133.598 1.00 29.19  ? 408 THR A C     1 
ATOM 1080 O O     . THR A 1 414 ? 145.691 125.027 134.112 1.00 45.59  ? 408 THR A O     1 
ATOM 1081 C CB    . THR A 1 414 ? 148.408 126.223 133.919 1.00 30.89  ? 408 THR A CB    1 
ATOM 1082 O OG1   . THR A 1 414 ? 149.409 126.800 134.764 1.00 37.71  ? 408 THR A OG1   1 
ATOM 1083 C CG2   . THR A 1 414 ? 148.866 126.307 132.475 1.00 37.55  ? 408 THR A CG2   1 
ATOM 1084 N N     . LYS A 1 415 ? 145.209 126.623 132.592 1.00 28.36  ? 409 LYS A N     1 
ATOM 1085 C CA    . LYS A 1 415 ? 144.000 125.945 132.136 1.00 35.81  ? 409 LYS A CA    1 
ATOM 1086 C C     . LYS A 1 415 ? 144.313 124.817 131.158 1.00 40.33  ? 409 LYS A C     1 
ATOM 1087 O O     . LYS A 1 415 ? 144.006 123.649 131.420 1.00 47.22  ? 409 LYS A O     1 
ATOM 1088 C CB    . LYS A 1 415 ? 143.040 126.951 131.500 1.00 37.68  ? 409 LYS A CB    1 
ATOM 1089 C CG    . LYS A 1 415 ? 141.624 126.859 132.023 1.00 32.84  ? 409 LYS A CG    1 
ATOM 1090 C CD    . LYS A 1 415 ? 140.865 128.156 131.815 1.00 29.70  ? 409 LYS A CD    1 
ATOM 1091 C CE    . LYS A 1 415 ? 140.963 128.637 130.383 1.00 36.08  ? 409 LYS A CE    1 
ATOM 1092 N NZ    . LYS A 1 415 ? 139.899 129.631 130.081 1.00 48.23  ? 409 LYS A NZ    1 
ATOM 1093 N N     . GLU A 1 419 ? 150.060 125.347 125.817 1.00 57.67  ? 413 GLU A N     1 
ATOM 1094 C CA    . GLU A 1 419 ? 150.977 126.375 126.266 1.00 57.81  ? 413 GLU A CA    1 
ATOM 1095 C C     . GLU A 1 419 ? 151.076 126.342 127.789 1.00 62.60  ? 413 GLU A C     1 
ATOM 1096 O O     . GLU A 1 419 ? 150.528 125.458 128.454 1.00 58.76  ? 413 GLU A O     1 
ATOM 1097 C CB    . GLU A 1 419 ? 150.521 127.743 125.756 1.00 56.41  ? 413 GLU A CB    1 
ATOM 1098 C CG    . GLU A 1 419 ? 149.178 128.191 126.310 1.00 60.63  ? 413 GLU A CG    1 
ATOM 1099 C CD    . GLU A 1 419 ? 148.155 128.446 125.223 1.00 62.05  ? 413 GLU A CD    1 
ATOM 1100 O OE1   . GLU A 1 419 ? 148.102 127.655 124.260 1.00 61.98  ? 413 GLU A OE1   1 
ATOM 1101 O OE2   . GLU A 1 419 ? 147.404 129.437 125.330 1.00 59.11  ? 413 GLU A OE2   1 
ATOM 1102 N N     . ASN A 1 420 ? 151.781 127.316 128.353 1.00 70.40  ? 414 ASN A N     1 
ATOM 1103 C CA    . ASN A 1 420 ? 151.938 127.454 129.794 1.00 68.90  ? 414 ASN A CA    1 
ATOM 1104 C C     . ASN A 1 420 ? 151.360 128.780 130.271 1.00 68.74  ? 414 ASN A C     1 
ATOM 1105 O O     . ASN A 1 420 ? 151.892 129.420 131.180 1.00 72.06  ? 414 ASN A O     1 
ATOM 1106 C CB    . ASN A 1 420 ? 153.405 127.326 130.196 1.00 69.97  ? 414 ASN A CB    1 
ATOM 1107 C CG    . ASN A 1 420 ? 154.333 128.051 129.243 1.00 73.48  ? 414 ASN A CG    1 
ATOM 1108 O OD1   . ASN A 1 420 ? 154.210 129.257 129.034 1.00 71.55  ? 414 ASN A OD1   1 
ATOM 1109 N ND2   . ASN A 1 420 ? 155.271 127.316 128.657 1.00 71.80  ? 414 ASN A ND2   1 
ATOM 1110 N N     . ARG A 1 421 ? 150.265 129.211 129.650 1.00 50.62  ? 415 ARG A N     1 
ATOM 1111 C CA    . ARG A 1 421 ? 149.627 130.464 130.029 1.00 49.20  ? 415 ARG A CA    1 
ATOM 1112 C C     . ARG A 1 421 ? 149.115 130.380 131.459 1.00 50.03  ? 415 ARG A C     1 
ATOM 1113 O O     . ARG A 1 421 ? 148.326 129.492 131.794 1.00 55.72  ? 415 ARG A O     1 
ATOM 1114 C CB    . ARG A 1 421 ? 148.485 130.779 129.066 1.00 52.88  ? 415 ARG A CB    1 
ATOM 1115 C CG    . ARG A 1 421 ? 147.673 132.007 129.433 1.00 52.12  ? 415 ARG A CG    1 
ATOM 1116 C CD    . ARG A 1 421 ? 147.081 132.651 128.187 1.00 54.88  ? 415 ARG A CD    1 
ATOM 1117 N NE    . ARG A 1 421 ? 145.791 133.284 128.438 1.00 52.57  ? 415 ARG A NE    1 
ATOM 1118 C CZ    . ARG A 1 421 ? 145.621 134.409 129.119 1.00 57.15  ? 415 ARG A CZ    1 
ATOM 1119 N NH1   . ARG A 1 421 ? 146.645 135.061 129.645 1.00 50.57  ? 415 ARG A NH1   1 
ATOM 1120 N NH2   . ARG A 1 421 ? 144.393 134.896 129.270 1.00 60.62  ? 415 ARG A NH2   1 
ATOM 1121 N N     . ARG A 1 422 ? 149.565 131.307 132.300 1.00 39.65  ? 416 ARG A N     1 
ATOM 1122 C CA    . ARG A 1 422 ? 149.230 131.312 133.723 1.00 35.83  ? 416 ARG A CA    1 
ATOM 1123 C C     . ARG A 1 422 ? 148.082 132.290 133.934 1.00 35.54  ? 416 ARG A C     1 
ATOM 1124 O O     . ARG A 1 422 ? 148.288 133.488 134.133 1.00 48.27  ? 416 ARG A O     1 
ATOM 1125 C CB    . ARG A 1 422 ? 150.450 131.675 134.560 1.00 37.05  ? 416 ARG A CB    1 
ATOM 1126 C CG    . ARG A 1 422 ? 151.639 130.759 134.337 1.00 41.26  ? 416 ARG A CG    1 
ATOM 1127 C CD    . ARG A 1 422 ? 152.197 130.235 135.648 1.00 45.52  ? 416 ARG A CD    1 
ATOM 1128 N NE    . ARG A 1 422 ? 151.324 129.241 136.258 1.00 43.80  ? 416 ARG A NE    1 
ATOM 1129 C CZ    . ARG A 1 422 ? 151.165 129.088 137.565 1.00 41.03  ? 416 ARG A CZ    1 
ATOM 1130 N NH1   . ARG A 1 422 ? 151.818 129.843 138.434 1.00 39.27  ? 416 ARG A NH1   1 
ATOM 1131 N NH2   . ARG A 1 422 ? 150.334 128.151 138.013 1.00 37.50  ? 416 ARG A NH2   1 
ATOM 1132 N N     . TYR A 1 423 ? 146.860 131.771 133.890 1.00 30.30  ? 417 TYR A N     1 
ATOM 1133 C CA    . TYR A 1 423 ? 145.685 132.597 134.109 1.00 29.55  ? 417 TYR A CA    1 
ATOM 1134 C C     . TYR A 1 423 ? 145.643 133.091 135.551 1.00 40.48  ? 417 TYR A C     1 
ATOM 1135 O O     . TYR A 1 423 ? 146.079 132.406 136.479 1.00 52.53  ? 417 TYR A O     1 
ATOM 1136 C CB    . TYR A 1 423 ? 144.413 131.814 133.791 1.00 40.89  ? 417 TYR A CB    1 
ATOM 1137 C CG    . TYR A 1 423 ? 144.260 131.456 132.333 1.00 42.26  ? 417 TYR A CG    1 
ATOM 1138 C CD1   . TYR A 1 423 ? 144.968 130.399 131.778 1.00 39.80  ? 417 TYR A CD1   1 
ATOM 1139 C CD2   . TYR A 1 423 ? 143.408 132.175 131.511 1.00 39.86  ? 417 TYR A CD2   1 
ATOM 1140 C CE1   . TYR A 1 423 ? 144.830 130.070 130.447 1.00 39.07  ? 417 TYR A CE1   1 
ATOM 1141 C CE2   . TYR A 1 423 ? 143.263 131.853 130.179 1.00 44.71  ? 417 TYR A CE2   1 
ATOM 1142 C CZ    . TYR A 1 423 ? 143.977 130.800 129.652 1.00 46.55  ? 417 TYR A CZ    1 
ATOM 1143 O OH    . TYR A 1 423 ? 143.831 130.478 128.323 1.00 47.37  ? 417 TYR A OH    1 
ATOM 1144 N N     . VAL A 1 424 ? 145.101 134.293 135.729 1.00 43.02  ? 418 VAL A N     1 
ATOM 1145 C CA    . VAL A 1 424 ? 145.035 134.955 137.026 1.00 36.71  ? 418 VAL A CA    1 
ATOM 1146 C C     . VAL A 1 424 ? 143.584 135.297 137.327 1.00 40.67  ? 418 VAL A C     1 
ATOM 1147 O O     . VAL A 1 424 ? 142.858 135.786 136.454 1.00 44.82  ? 418 VAL A O     1 
ATOM 1148 C CB    . VAL A 1 424 ? 145.914 136.224 137.059 1.00 37.38  ? 418 VAL A CB    1 
ATOM 1149 C CG1   . VAL A 1 424 ? 145.777 136.933 138.394 1.00 34.29  ? 418 VAL A CG1   1 
ATOM 1150 C CG2   . VAL A 1 424 ? 147.365 135.873 136.785 1.00 41.61  ? 418 VAL A CG2   1 
ATOM 1151 N N     . GLY A 1 425 ? 143.163 135.034 138.563 1.00 35.23  ? 419 GLY A N     1 
ATOM 1152 C CA    . GLY A 1 425 ? 141.811 135.343 138.981 1.00 34.37  ? 419 GLY A CA    1 
ATOM 1153 C C     . GLY A 1 425 ? 141.769 135.752 140.436 1.00 36.84  ? 419 GLY A C     1 
ATOM 1154 O O     . GLY A 1 425 ? 142.723 135.551 141.190 1.00 41.62  ? 419 GLY A O     1 
ATOM 1155 N N     . GLU A 1 426 ? 140.640 136.339 140.826 1.00 37.92  ? 420 GLU A N     1 
ATOM 1156 C CA    . GLU A 1 426 ? 140.400 136.763 142.198 1.00 23.21  ? 420 GLU A CA    1 
ATOM 1157 C C     . GLU A 1 426 ? 139.195 136.018 142.743 1.00 31.33  ? 420 GLU A C     1 
ATOM 1158 O O     . GLU A 1 426 ? 138.122 136.035 142.134 1.00 44.79  ? 420 GLU A O     1 
ATOM 1159 C CB    . GLU A 1 426 ? 140.163 138.273 142.281 1.00 26.78  ? 420 GLU A CB    1 
ATOM 1160 C CG    . GLU A 1 426 ? 141.373 139.113 141.925 1.00 42.23  ? 420 GLU A CG    1 
ATOM 1161 C CD    . GLU A 1 426 ? 141.834 139.982 143.075 1.00 49.21  ? 420 GLU A CD    1 
ATOM 1162 O OE1   . GLU A 1 426 ? 141.534 139.641 144.236 1.00 45.74  ? 420 GLU A OE1   1 
ATOM 1163 O OE2   . GLU A 1 426 ? 142.498 141.008 142.820 1.00 50.60  ? 420 GLU A OE2   1 
ATOM 1164 N N     . VAL A 1 427 ? 139.369 135.378 143.896 1.00 31.62  ? 421 VAL A N     1 
ATOM 1165 C CA    . VAL A 1 427 ? 138.319 134.609 144.551 1.00 27.39  ? 421 VAL A CA    1 
ATOM 1166 C C     . VAL A 1 427 ? 137.874 135.364 145.794 1.00 34.30  ? 421 VAL A C     1 
ATOM 1167 O O     . VAL A 1 427 ? 138.702 135.728 146.640 1.00 39.05  ? 421 VAL A O     1 
ATOM 1168 C CB    . VAL A 1 427 ? 138.795 133.192 144.910 1.00 24.74  ? 421 VAL A CB    1 
ATOM 1169 C CG1   . VAL A 1 427 ? 137.657 132.386 145.508 1.00 29.47  ? 421 VAL A CG1   1 
ATOM 1170 C CG2   . VAL A 1 427 ? 139.346 132.499 143.685 1.00 27.61  ? 421 VAL A CG2   1 
ATOM 1171 N N     . LYS A 1 428 ? 136.568 135.610 145.893 1.00 35.80  ? 422 LYS A N     1 
ATOM 1172 C CA    . LYS A 1 428 ? 135.971 136.259 147.051 1.00 31.80  ? 422 LYS A CA    1 
ATOM 1173 C C     . LYS A 1 428 ? 134.812 135.487 147.655 1.00 32.26  ? 422 LYS A C     1 
ATOM 1174 O O     . LYS A 1 428 ? 134.486 135.723 148.825 1.00 37.20  ? 422 LYS A O     1 
ATOM 1175 C CB    . LYS A 1 428 ? 135.479 137.667 146.684 1.00 30.70  ? 422 LYS A CB    1 
ATOM 1176 C CG    . LYS A 1 428 ? 136.561 138.572 146.146 1.00 32.54  ? 422 LYS A CG    1 
ATOM 1177 C CD    . LYS A 1 428 ? 136.088 139.350 144.936 1.00 35.28  ? 422 LYS A CD    1 
ATOM 1178 C CE    . LYS A 1 428 ? 137.174 140.274 144.427 1.00 28.31  ? 422 LYS A CE    1 
ATOM 1179 N NZ    . LYS A 1 428 ? 136.601 141.513 143.839 1.00 31.68  ? 422 LYS A NZ    1 
ATOM 1180 N N     . GLU A 1 429 ? 134.176 134.590 146.908 1.00 30.55  ? 423 GLU A N     1 
ATOM 1181 C CA    . GLU A 1 429 ? 133.085 133.774 147.417 1.00 19.67  ? 423 GLU A CA    1 
ATOM 1182 C C     . GLU A 1 429 ? 133.221 132.366 146.864 1.00 29.98  ? 423 GLU A C     1 
ATOM 1183 O O     . GLU A 1 429 ? 133.687 132.165 145.740 1.00 43.14  ? 423 GLU A O     1 
ATOM 1184 C CB    . GLU A 1 429 ? 131.721 134.356 147.039 1.00 35.35  ? 423 GLU A CB    1 
ATOM 1185 C CG    . GLU A 1 429 ? 130.680 134.259 148.135 1.00 35.09  ? 423 GLU A CG    1 
ATOM 1186 C CD    . GLU A 1 429 ? 129.668 135.377 148.062 1.00 35.65  ? 423 GLU A CD    1 
ATOM 1187 O OE1   . GLU A 1 429 ? 129.912 136.439 148.671 1.00 27.41  ? 423 GLU A OE1   1 
ATOM 1188 O OE2   . GLU A 1 429 ? 128.630 135.198 147.394 1.00 37.15  ? 423 GLU A OE2   1 
ATOM 1189 N N     . ILE A 1 430 ? 132.805 131.391 147.665 1.00 36.30  ? 424 ILE A N     1 
ATOM 1190 C CA    . ILE A 1 430 ? 132.865 129.985 147.297 1.00 26.48  ? 424 ILE A CA    1 
ATOM 1191 C C     . ILE A 1 430 ? 131.492 129.377 147.542 1.00 31.72  ? 424 ILE A C     1 
ATOM 1192 O O     . ILE A 1 430 ? 130.721 129.862 148.374 1.00 46.65  ? 424 ILE A O     1 
ATOM 1193 C CB    . ILE A 1 430 ? 133.967 129.242 148.087 1.00 22.80  ? 424 ILE A CB    1 
ATOM 1194 C CG1   . ILE A 1 430 ? 134.682 128.228 147.199 1.00 27.72  ? 424 ILE A CG1   1 
ATOM 1195 C CG2   . ILE A 1 430 ? 133.399 128.563 149.317 1.00 27.68  ? 424 ILE A CG2   1 
ATOM 1196 C CD1   . ILE A 1 430 ? 135.994 127.756 147.775 1.00 29.86  ? 424 ILE A CD1   1 
ATOM 1197 N N     . GLY A 1 431 ? 131.177 128.327 146.803 1.00 20.28  ? 425 GLY A N     1 
ATOM 1198 C CA    . GLY A 1 431 ? 129.870 127.697 146.894 1.00 25.19  ? 425 GLY A CA    1 
ATOM 1199 C C     . GLY A 1 431 ? 129.975 126.190 146.945 1.00 31.17  ? 425 GLY A C     1 
ATOM 1200 O O     . GLY A 1 431 ? 130.804 125.592 146.265 1.00 40.13  ? 425 GLY A O     1 
ATOM 1201 N N     . LEU A 1 432 ? 129.112 125.581 147.752 1.00 33.19  ? 426 LEU A N     1 
ATOM 1202 C CA    . LEU A 1 432 ? 129.119 124.142 147.982 1.00 42.60  ? 426 LEU A CA    1 
ATOM 1203 C C     . LEU A 1 432 ? 127.796 123.544 147.535 1.00 44.91  ? 426 LEU A C     1 
ATOM 1204 O O     . LEU A 1 432 ? 126.729 124.026 147.927 1.00 47.48  ? 426 LEU A O     1 
ATOM 1205 C CB    . LEU A 1 432 ? 129.370 123.823 149.457 1.00 35.44  ? 426 LEU A CB    1 
ATOM 1206 C CG    . LEU A 1 432 ? 129.393 122.348 149.851 1.00 36.35  ? 426 LEU A CG    1 
ATOM 1207 C CD1   . LEU A 1 432 ? 130.788 121.769 149.698 1.00 38.13  ? 426 LEU A CD1   1 
ATOM 1208 C CD2   . LEU A 1 432 ? 128.895 122.172 151.274 1.00 37.78  ? 426 LEU A CD2   1 
ATOM 1209 N N     . VAL A 1 433 ? 127.866 122.492 146.715 1.00 45.10  ? 427 VAL A N     1 
ATOM 1210 C CA    . VAL A 1 433 ? 126.683 121.780 146.251 1.00 39.93  ? 427 VAL A CA    1 
ATOM 1211 C C     . VAL A 1 433 ? 126.915 120.283 146.413 1.00 44.18  ? 427 VAL A C     1 
ATOM 1212 O O     . VAL A 1 433 ? 128.027 119.828 146.680 1.00 55.38  ? 427 VAL A O     1 
ATOM 1213 C CB    . VAL A 1 433 ? 126.329 122.102 144.787 1.00 37.87  ? 427 VAL A CB    1 
ATOM 1214 C CG1   . VAL A 1 433 ? 126.044 123.584 144.619 1.00 41.45  ? 427 VAL A CG1   1 
ATOM 1215 C CG2   . VAL A 1 433 ? 127.441 121.642 143.866 1.00 38.46  ? 427 VAL A CG2   1 
ATOM 1216 N N     . ARG A 1 434 ? 125.842 119.518 146.226 1.00 52.25  ? 428 ARG A N     1 
ATOM 1217 C CA    . ARG A 1 434 ? 125.874 118.064 146.345 1.00 45.28  ? 428 ARG A CA    1 
ATOM 1218 C C     . ARG A 1 434 ? 125.169 117.460 145.139 1.00 52.11  ? 428 ARG A C     1 
ATOM 1219 O O     . ARG A 1 434 ? 123.961 117.653 144.960 1.00 57.28  ? 428 ARG A O     1 
ATOM 1220 C CB    . ARG A 1 434 ? 125.215 117.607 147.646 1.00 49.78  ? 428 ARG A CB    1 
ATOM 1221 C CG    . ARG A 1 434 ? 125.492 116.161 148.006 1.00 60.79  ? 428 ARG A CG    1 
ATOM 1222 C CD    . ARG A 1 434 ? 124.281 115.514 148.657 1.00 56.01  ? 428 ARG A CD    1 
ATOM 1223 N NE    . ARG A 1 434 ? 124.244 115.739 150.096 1.00 53.78  ? 428 ARG A NE    1 
ATOM 1224 C CZ    . ARG A 1 434 ? 123.130 115.820 150.812 1.00 56.27  ? 428 ARG A CZ    1 
ATOM 1225 N NH1   . ARG A 1 434 ? 121.939 115.705 150.250 1.00 59.34  ? 428 ARG A NH1   1 
ATOM 1226 N NH2   . ARG A 1 434 ? 123.214 116.023 152.122 1.00 55.16  ? 428 ARG A NH2   1 
ATOM 1227 N N     . GLN A 1 435 ? 125.920 116.737 144.311 1.00 58.16  ? 429 GLN A N     1 
ATOM 1228 C CA    . GLN A 1 435 ? 125.380 116.017 143.165 1.00 59.29  ? 429 GLN A CA    1 
ATOM 1229 C C     . GLN A 1 435 ? 125.694 114.539 143.326 1.00 64.87  ? 429 GLN A C     1 
ATOM 1230 O O     . GLN A 1 435 ? 126.867 114.156 143.387 1.00 64.88  ? 429 GLN A O     1 
ATOM 1231 C CB    . GLN A 1 435 ? 125.964 116.538 141.852 1.00 54.38  ? 429 GLN A CB    1 
ATOM 1232 C CG    . GLN A 1 435 ? 126.080 118.042 141.768 1.00 58.80  ? 429 GLN A CG    1 
ATOM 1233 C CD    . GLN A 1 435 ? 127.126 118.481 140.766 1.00 63.21  ? 429 GLN A CD    1 
ATOM 1234 O OE1   . GLN A 1 435 ? 127.878 119.424 141.006 1.00 62.55  ? 429 GLN A OE1   1 
ATOM 1235 N NE2   . GLN A 1 435 ? 127.180 117.792 139.632 1.00 58.64  ? 429 GLN A NE2   1 
ATOM 1236 N N     . ARG A 1 436 ? 124.648 113.712 143.382 1.00 64.33  ? 430 ARG A N     1 
ATOM 1237 C CA    . ARG A 1 436 ? 124.793 112.261 143.507 1.00 63.13  ? 430 ARG A CA    1 
ATOM 1238 C C     . ARG A 1 436 ? 125.647 111.895 144.718 1.00 67.54  ? 430 ARG A C     1 
ATOM 1239 O O     . ARG A 1 436 ? 126.531 111.036 144.646 1.00 70.45  ? 430 ARG A O     1 
ATOM 1240 C CB    . ARG A 1 436 ? 125.373 111.654 142.228 1.00 65.43  ? 430 ARG A CB    1 
ATOM 1241 C CG    . ARG A 1 436 ? 124.335 111.056 141.292 1.00 67.23  ? 430 ARG A CG    1 
ATOM 1242 C CD    . ARG A 1 436 ? 123.389 112.122 140.770 1.00 66.31  ? 430 ARG A CD    1 
ATOM 1243 N NE    . ARG A 1 436 ? 124.091 113.141 140.000 1.00 66.28  ? 430 ARG A NE    1 
ATOM 1244 C CZ    . ARG A 1 436 ? 124.090 113.211 138.676 1.00 68.27  ? 430 ARG A CZ    1 
ATOM 1245 N NH1   . ARG A 1 436 ? 123.428 112.336 137.937 1.00 68.55  ? 430 ARG A NH1   1 
ATOM 1246 N NH2   . ARG A 1 436 ? 124.772 114.184 138.079 1.00 69.46  ? 430 ARG A NH2   1 
ATOM 1247 N N     . GLY A 1 437 ? 125.389 112.561 145.840 1.00 57.93  ? 431 GLY A N     1 
ATOM 1248 C CA    . GLY A 1 437 ? 126.153 112.316 147.046 1.00 58.36  ? 431 GLY A CA    1 
ATOM 1249 C C     . GLY A 1 437 ? 127.594 112.765 146.993 1.00 58.26  ? 431 GLY A C     1 
ATOM 1250 O O     . GLY A 1 437 ? 128.376 112.389 147.870 1.00 61.39  ? 431 GLY A O     1 
ATOM 1251 N N     . ARG A 1 438 ? 127.971 113.557 145.995 1.00 51.53  ? 432 ARG A N     1 
ATOM 1252 C CA    . ARG A 1 438 ? 129.324 114.074 145.850 1.00 57.19  ? 432 ARG A CA    1 
ATOM 1253 C C     . ARG A 1 438 ? 129.308 115.574 146.102 1.00 54.90  ? 432 ARG A C     1 
ATOM 1254 O O     . ARG A 1 438 ? 128.496 116.294 145.517 1.00 57.33  ? 432 ARG A O     1 
ATOM 1255 C CB    . ARG A 1 438 ? 129.873 113.778 144.455 1.00 57.77  ? 432 ARG A CB    1 
ATOM 1256 C CG    . ARG A 1 438 ? 129.779 112.323 144.043 1.00 58.66  ? 432 ARG A CG    1 
ATOM 1257 C CD    . ARG A 1 438 ? 131.139 111.645 144.088 1.00 55.26  ? 432 ARG A CD    1 
ATOM 1258 N NE    . ARG A 1 438 ? 132.030 112.138 143.045 1.00 55.73  ? 432 ARG A NE    1 
ATOM 1259 C CZ    . ARG A 1 438 ? 131.906 111.860 141.754 1.00 51.84  ? 432 ARG A CZ    1 
ATOM 1260 N NH1   . ARG A 1 438 ? 130.939 111.077 141.305 1.00 52.63  ? 432 ARG A NH1   1 
ATOM 1261 N NH2   . ARG A 1 438 ? 132.777 112.377 140.891 1.00 48.63  ? 432 ARG A NH2   1 
ATOM 1262 N N     . TYR A 1 439 ? 130.202 116.020 146.980 1.00 49.90  ? 433 TYR A N     1 
ATOM 1263 C CA    . TYR A 1 439 ? 130.263 117.433 147.322 1.00 51.12  ? 433 TYR A CA    1 
ATOM 1264 C C     . TYR A 1 439 ? 131.214 118.178 146.414 1.00 52.52  ? 433 TYR A C     1 
ATOM 1265 O O     . TYR A 1 439 ? 132.365 117.780 146.242 1.00 63.50  ? 433 TYR A O     1 
ATOM 1266 C CB    . TYR A 1 439 ? 130.650 117.604 148.792 1.00 56.55  ? 433 TYR A CB    1 
ATOM 1267 C CG    . TYR A 1 439 ? 129.591 117.078 149.732 1.00 54.50  ? 433 TYR A CG    1 
ATOM 1268 C CD1   . TYR A 1 439 ? 129.735 115.845 150.353 1.00 53.32  ? 433 TYR A CD1   1 
ATOM 1269 C CD2   . TYR A 1 439 ? 128.435 117.804 149.980 1.00 53.07  ? 433 TYR A CD2   1 
ATOM 1270 C CE1   . TYR A 1 439 ? 128.763 115.357 151.207 1.00 55.62  ? 433 TYR A CE1   1 
ATOM 1271 C CE2   . TYR A 1 439 ? 127.459 117.324 150.832 1.00 55.84  ? 433 TYR A CE2   1 
ATOM 1272 C CZ    . TYR A 1 439 ? 127.627 116.102 151.442 1.00 60.68  ? 433 TYR A CZ    1 
ATOM 1273 O OH    . TYR A 1 439 ? 126.654 115.626 152.291 1.00 61.78  ? 433 TYR A OH    1 
ATOM 1274 N N     . TYR A 1 440 ? 130.735 119.264 145.836 1.00 39.31  ? 434 TYR A N     1 
ATOM 1275 C CA    . TYR A 1 440 ? 131.525 120.054 144.904 1.00 41.39  ? 434 TYR A CA    1 
ATOM 1276 C C     . TYR A 1 440 ? 131.614 121.495 145.379 1.00 49.39  ? 434 TYR A C     1 
ATOM 1277 O O     . TYR A 1 440 ? 130.661 122.041 145.948 1.00 56.16  ? 434 TYR A O     1 
ATOM 1278 C CB    . TYR A 1 440 ? 130.926 120.027 143.493 1.00 40.35  ? 434 TYR A CB    1 
ATOM 1279 C CG    . TYR A 1 440 ? 131.012 118.691 142.801 1.00 42.66  ? 434 TYR A CG    1 
ATOM 1280 C CD1   . TYR A 1 440 ? 132.121 118.350 142.041 1.00 48.78  ? 434 TYR A CD1   1 
ATOM 1281 C CD2   . TYR A 1 440 ? 129.975 117.773 142.894 1.00 42.67  ? 434 TYR A CD2   1 
ATOM 1282 C CE1   . TYR A 1 440 ? 132.199 117.131 141.402 1.00 48.03  ? 434 TYR A CE1   1 
ATOM 1283 C CE2   . TYR A 1 440 ? 130.045 116.554 142.258 1.00 45.33  ? 434 TYR A CE2   1 
ATOM 1284 C CZ    . TYR A 1 440 ? 131.158 116.237 141.514 1.00 50.21  ? 434 TYR A CZ    1 
ATOM 1285 O OH    . TYR A 1 440 ? 131.228 115.019 140.881 1.00 56.25  ? 434 TYR A OH    1 
ATOM 1286 N N     . PHE A 1 441 ? 132.768 122.110 145.127 1.00 36.92  ? 435 PHE A N     1 
ATOM 1287 C CA    . PHE A 1 441 ? 133.006 123.516 145.419 1.00 26.31  ? 435 PHE A CA    1 
ATOM 1288 C C     . PHE A 1 441 ? 133.130 124.290 144.115 1.00 35.08  ? 435 PHE A C     1 
ATOM 1289 O O     . PHE A 1 441 ? 133.930 123.926 143.244 1.00 41.41  ? 435 PHE A O     1 
ATOM 1290 C CB    . PHE A 1 441 ? 134.273 123.697 146.258 1.00 25.54  ? 435 PHE A CB    1 
ATOM 1291 C CG    . PHE A 1 441 ? 134.018 123.789 147.733 1.00 30.89  ? 435 PHE A CG    1 
ATOM 1292 C CD1   . PHE A 1 441 ? 133.069 124.659 148.233 1.00 33.97  ? 435 PHE A CD1   1 
ATOM 1293 C CD2   . PHE A 1 441 ? 134.732 123.003 148.622 1.00 41.54  ? 435 PHE A CD2   1 
ATOM 1294 C CE1   . PHE A 1 441 ? 132.836 124.746 149.590 1.00 33.91  ? 435 PHE A CE1   1 
ATOM 1295 C CE2   . PHE A 1 441 ? 134.502 123.084 149.979 1.00 42.52  ? 435 PHE A CE2   1 
ATOM 1296 C CZ    . PHE A 1 441 ? 133.552 123.957 150.464 1.00 35.29  ? 435 PHE A CZ    1 
ATOM 1297 N N     . PHE A 1 442 ? 132.336 125.352 143.987 1.00 30.52  ? 436 PHE A N     1 
ATOM 1298 C CA    . PHE A 1 442 ? 132.364 126.236 142.827 1.00 20.97  ? 436 PHE A CA    1 
ATOM 1299 C C     . PHE A 1 442 ? 133.372 127.348 143.087 1.00 29.62  ? 436 PHE A C     1 
ATOM 1300 O O     . PHE A 1 442 ? 133.150 128.201 143.950 1.00 42.73  ? 436 PHE A O     1 
ATOM 1301 C CB    . PHE A 1 442 ? 130.984 126.838 142.573 1.00 28.74  ? 436 PHE A CB    1 
ATOM 1302 C CG    . PHE A 1 442 ? 130.027 125.916 141.884 1.00 37.31  ? 436 PHE A CG    1 
ATOM 1303 C CD1   . PHE A 1 442 ? 130.077 125.742 140.515 1.00 38.74  ? 436 PHE A CD1   1 
ATOM 1304 C CD2   . PHE A 1 442 ? 129.059 125.245 142.602 1.00 31.97  ? 436 PHE A CD2   1 
ATOM 1305 C CE1   . PHE A 1 442 ? 129.190 124.904 139.881 1.00 32.93  ? 436 PHE A CE1   1 
ATOM 1306 C CE2   . PHE A 1 442 ? 128.172 124.407 141.969 1.00 30.29  ? 436 PHE A CE2   1 
ATOM 1307 C CZ    . PHE A 1 442 ? 128.238 124.235 140.610 1.00 31.42  ? 436 PHE A CZ    1 
ATOM 1308 N N     . ILE A 1 443 ? 134.477 127.352 142.348 1.00 33.01  ? 437 ILE A N     1 
ATOM 1309 C CA    . ILE A 1 443 ? 135.469 128.430 142.469 1.00 23.95  ? 437 ILE A CA    1 
ATOM 1310 C C     . ILE A 1 443 ? 135.077 129.478 141.432 1.00 28.47  ? 437 ILE A C     1 
ATOM 1311 O O     . ILE A 1 443 ? 135.594 129.534 140.316 1.00 38.61  ? 437 ILE A O     1 
ATOM 1312 C CB    . ILE A 1 443 ? 136.902 127.923 142.290 1.00 18.98  ? 437 ILE A CB    1 
ATOM 1313 C CG1   . ILE A 1 443 ? 137.086 126.588 143.010 1.00 24.01  ? 437 ILE A CG1   1 
ATOM 1314 C CG2   . ILE A 1 443 ? 137.896 128.945 142.809 1.00 27.31  ? 437 ILE A CG2   1 
ATOM 1315 C CD1   . ILE A 1 443 ? 137.101 126.701 144.509 1.00 23.71  ? 437 ILE A CD1   1 
ATOM 1316 N N     . ASP A 1 444 ? 134.135 130.337 141.817 1.00 24.81  ? 438 ASP A N     1 
ATOM 1317 C CA    . ASP A 1 444 ? 133.715 131.448 140.969 1.00 30.73  ? 438 ASP A CA    1 
ATOM 1318 C C     . ASP A 1 444 ? 134.691 132.597 141.175 1.00 35.71  ? 438 ASP A C     1 
ATOM 1319 O O     . ASP A 1 444 ? 134.701 133.224 142.238 1.00 43.52  ? 438 ASP A O     1 
ATOM 1320 C CB    . ASP A 1 444 ? 132.292 131.880 141.307 1.00 31.76  ? 438 ASP A CB    1 
ATOM 1321 C CG    . ASP A 1 444 ? 131.299 130.745 141.215 1.00 47.85  ? 438 ASP A CG    1 
ATOM 1322 O OD1   . ASP A 1 444 ? 131.195 130.127 140.136 1.00 47.82  ? 438 ASP A OD1   1 
ATOM 1323 O OD2   . ASP A 1 444 ? 130.611 130.474 142.221 1.00 50.64  ? 438 ASP A OD2   1 
ATOM 1324 N N     . TYR A 1 445 ? 135.508 132.887 140.168 1.00 20.84  ? 439 TYR A N     1 
ATOM 1325 C CA    . TYR A 1 445 ? 136.577 133.860 140.308 1.00 28.11  ? 439 TYR A CA    1 
ATOM 1326 C C     . TYR A 1 445 ? 136.424 134.975 139.285 1.00 32.07  ? 439 TYR A C     1 
ATOM 1327 O O     . TYR A 1 445 ? 136.066 134.730 138.128 1.00 42.24  ? 439 TYR A O     1 
ATOM 1328 C CB    . TYR A 1 445 ? 137.951 133.193 140.165 1.00 31.46  ? 439 TYR A CB    1 
ATOM 1329 C CG    . TYR A 1 445 ? 138.253 132.640 138.789 1.00 28.63  ? 439 TYR A CG    1 
ATOM 1330 C CD1   . TYR A 1 445 ? 137.861 131.358 138.436 1.00 30.46  ? 439 TYR A CD1   1 
ATOM 1331 C CD2   . TYR A 1 445 ? 138.949 133.391 137.853 1.00 27.61  ? 439 TYR A CD2   1 
ATOM 1332 C CE1   . TYR A 1 445 ? 138.138 130.849 137.187 1.00 31.20  ? 439 TYR A CE1   1 
ATOM 1333 C CE2   . TYR A 1 445 ? 139.231 132.887 136.603 1.00 24.69  ? 439 TYR A CE2   1 
ATOM 1334 C CZ    . TYR A 1 445 ? 138.824 131.616 136.276 1.00 25.14  ? 439 TYR A CZ    1 
ATOM 1335 O OH    . TYR A 1 445 ? 139.102 131.109 135.031 1.00 35.08  ? 439 TYR A OH    1 
ATOM 1336 N N     . ASN A 1 446 ? 136.688 136.199 139.729 1.00 21.29  ? 440 ASN A N     1 
ATOM 1337 C CA    . ASN A 1 446 ? 136.739 137.344 138.836 1.00 26.94  ? 440 ASN A CA    1 
ATOM 1338 C C     . ASN A 1 446 ? 138.044 137.338 138.052 1.00 32.79  ? 440 ASN A C     1 
ATOM 1339 O O     . ASN A 1 446 ? 139.051 136.772 138.486 1.00 36.93  ? 440 ASN A O     1 
ATOM 1340 C CB    . ASN A 1 446 ? 136.617 138.647 139.624 1.00 30.24  ? 440 ASN A CB    1 
ATOM 1341 C CG    . ASN A 1 446 ? 135.595 138.564 140.734 1.00 36.15  ? 440 ASN A CG    1 
ATOM 1342 O OD1   . ASN A 1 446 ? 135.724 137.757 141.652 1.00 36.56  ? 440 ASN A OD1   1 
ATOM 1343 N ND2   . ASN A 1 446 ? 134.574 139.406 140.661 1.00 38.99  ? 440 ASN A ND2   1 
ATOM 1344 N N     . PHE A 1 447 ? 138.020 137.977 136.886 1.00 33.43  ? 441 PHE A N     1 
ATOM 1345 C CA    . PHE A 1 447 ? 139.218 138.095 136.072 1.00 35.38  ? 441 PHE A CA    1 
ATOM 1346 C C     . PHE A 1 447 ? 139.162 139.404 135.303 1.00 41.74  ? 441 PHE A C     1 
ATOM 1347 O O     . PHE A 1 447 ? 138.099 140.009 135.143 1.00 45.86  ? 441 PHE A O     1 
ATOM 1348 C CB    . PHE A 1 447 ? 139.377 136.901 135.120 1.00 39.18  ? 441 PHE A CB    1 
ATOM 1349 C CG    . PHE A 1 447 ? 138.513 136.976 133.896 1.00 33.98  ? 441 PHE A CG    1 
ATOM 1350 C CD1   . PHE A 1 447 ? 137.143 136.815 133.988 1.00 32.51  ? 441 PHE A CD1   1 
ATOM 1351 C CD2   . PHE A 1 447 ? 139.071 137.204 132.652 1.00 34.31  ? 441 PHE A CD2   1 
ATOM 1352 C CE1   . PHE A 1 447 ? 136.350 136.882 132.863 1.00 33.96  ? 441 PHE A CE1   1 
ATOM 1353 C CE2   . PHE A 1 447 ? 138.279 137.273 131.527 1.00 35.18  ? 441 PHE A CE2   1 
ATOM 1354 C CZ    . PHE A 1 447 ? 136.918 137.112 131.634 1.00 32.56  ? 441 PHE A CZ    1 
ATOM 1355 N N     . ASP A 1 448 ? 140.327 139.842 134.838 1.00 43.21  ? 442 ASP A N     1 
ATOM 1356 C CA    . ASP A 1 448 ? 140.449 141.111 134.129 1.00 36.48  ? 442 ASP A CA    1 
ATOM 1357 C C     . ASP A 1 448 ? 140.634 140.857 132.641 1.00 40.37  ? 442 ASP A C     1 
ATOM 1358 O O     . ASP A 1 448 ? 141.665 140.298 132.237 1.00 50.92  ? 442 ASP A O     1 
ATOM 1359 C CB    . ASP A 1 448 ? 141.620 141.923 134.679 1.00 36.12  ? 442 ASP A CB    1 
ATOM 1360 C CG    . ASP A 1 448 ? 141.347 142.467 136.065 1.00 50.26  ? 442 ASP A CG    1 
ATOM 1361 O OD1   . ASP A 1 448 ? 141.597 141.741 137.050 1.00 51.99  ? 442 ASP A OD1   1 
ATOM 1362 O OD2   . ASP A 1 448 ? 140.878 143.620 136.170 1.00 54.51  ? 442 ASP A OD2   1 
ATOM 1363 N N     . PRO A 1 449 ? 139.680 141.237 131.794 1.00 44.26  ? 443 PRO A N     1 
ATOM 1364 C CA    . PRO A 1 449 ? 139.853 141.047 130.353 1.00 40.57  ? 443 PRO A CA    1 
ATOM 1365 C C     . PRO A 1 449 ? 140.993 141.897 129.817 1.00 48.76  ? 443 PRO A C     1 
ATOM 1366 O O     . PRO A 1 449 ? 141.380 142.913 130.400 1.00 60.83  ? 443 PRO A O     1 
ATOM 1367 C CB    . PRO A 1 449 ? 138.508 141.488 129.766 1.00 45.20  ? 443 PRO A CB    1 
ATOM 1368 C CG    . PRO A 1 449 ? 137.553 141.462 130.919 1.00 46.55  ? 443 PRO A CG    1 
ATOM 1369 C CD    . PRO A 1 449 ? 138.365 141.806 132.121 1.00 47.19  ? 443 PRO A CD    1 
ATOM 1370 N N     . GLU A 1 450 ? 141.540 141.458 128.686 1.00 51.28  ? 444 GLU A N     1 
ATOM 1371 C CA    . GLU A 1 450 ? 142.673 142.148 128.091 1.00 47.67  ? 444 GLU A CA    1 
ATOM 1372 C C     . GLU A 1 450 ? 142.284 143.565 127.686 1.00 49.04  ? 444 GLU A C     1 
ATOM 1373 O O     . GLU A 1 450 ? 141.138 143.840 127.318 1.00 55.77  ? 444 GLU A O     1 
ATOM 1374 C CB    . GLU A 1 450 ? 143.192 141.377 126.877 1.00 50.39  ? 444 GLU A CB    1 
ATOM 1375 C CG    . GLU A 1 450 ? 143.608 139.949 127.189 1.00 58.05  ? 444 GLU A CG    1 
ATOM 1376 C CD    . GLU A 1 450 ? 145.028 139.857 127.707 1.00 58.16  ? 444 GLU A CD    1 
ATOM 1377 O OE1   . GLU A 1 450 ? 145.905 140.559 127.161 1.00 56.76  ? 444 GLU A OE1   1 
ATOM 1378 O OE2   . GLU A 1 450 ? 145.266 139.089 128.661 1.00 56.84  ? 444 GLU A OE2   1 
ATOM 1379 N N     . GLU A 1 451 ? 143.254 144.470 127.770 1.00 57.37  ? 445 GLU A N     1 
ATOM 1380 C CA    . GLU A 1 451 ? 143.005 145.871 127.470 1.00 60.74  ? 445 GLU A CA    1 
ATOM 1381 C C     . GLU A 1 451 ? 142.685 146.057 125.993 1.00 63.22  ? 445 GLU A C     1 
ATOM 1382 O O     . GLU A 1 451 ? 143.345 145.484 125.121 1.00 65.92  ? 445 GLU A O     1 
ATOM 1383 C CB    . GLU A 1 451 ? 144.219 146.718 127.854 1.00 65.82  ? 445 GLU A CB    1 
ATOM 1384 C CG    . GLU A 1 451 ? 143.912 148.188 128.071 1.00 68.93  ? 445 GLU A CG    1 
ATOM 1385 C CD    . GLU A 1 451 ? 144.615 149.084 127.069 1.00 69.78  ? 445 GLU A CD    1 
ATOM 1386 O OE1   . GLU A 1 451 ? 145.372 148.557 126.228 1.00 62.54  ? 445 GLU A OE1   1 
ATOM 1387 O OE2   . GLU A 1 451 ? 144.412 150.314 127.125 1.00 68.81  ? 445 GLU A OE2   1 
ATOM 1388 N N     . VAL A 1 452 ? 141.662 146.859 125.716 1.00 59.55  ? 446 VAL A N     1 
ATOM 1389 C CA    . VAL A 1 452 ? 141.264 147.203 124.357 1.00 61.70  ? 446 VAL A CA    1 
ATOM 1390 C C     . VAL A 1 452 ? 141.557 148.679 124.133 1.00 63.85  ? 446 VAL A C     1 
ATOM 1391 O O     . VAL A 1 452 ? 141.132 149.534 124.920 1.00 65.77  ? 446 VAL A O     1 
ATOM 1392 C CB    . VAL A 1 452 ? 139.783 146.868 124.094 1.00 60.87  ? 446 VAL A CB    1 
ATOM 1393 C CG1   . VAL A 1 452 ? 138.874 147.543 125.110 1.00 63.61  ? 446 VAL A CG1   1 
ATOM 1394 C CG2   . VAL A 1 452 ? 139.394 147.268 122.684 1.00 59.40  ? 446 VAL A CG2   1 
ATOM 1395 N N     . SER A 1 453 ? 142.308 148.974 123.078 1.00 68.88  ? 447 SER A N     1 
ATOM 1396 C CA    . SER A 1 453 ? 142.693 150.349 122.795 1.00 67.42  ? 447 SER A CA    1 
ATOM 1397 C C     . SER A 1 453 ? 141.490 151.166 122.347 1.00 69.74  ? 447 SER A C     1 
ATOM 1398 O O     . SER A 1 453 ? 140.509 150.636 121.819 1.00 71.65  ? 447 SER A O     1 
ATOM 1399 C CB    . SER A 1 453 ? 143.777 150.386 121.719 1.00 61.72  ? 447 SER A CB    1 
ATOM 1400 O OG    . SER A 1 453 ? 143.846 151.665 121.112 1.00 66.93  ? 447 SER A OG    1 
ATOM 1401 N N     . ASP A 1 454 ? 141.568 152.478 122.571 1.00 72.80  ? 448 ASP A N     1 
ATOM 1402 C CA    . ASP A 1 454 ? 140.544 153.375 122.054 1.00 69.48  ? 448 ASP A CA    1 
ATOM 1403 C C     . ASP A 1 454 ? 140.599 153.490 120.536 1.00 70.90  ? 448 ASP A C     1 
ATOM 1404 O O     . ASP A 1 454 ? 139.583 153.820 119.910 1.00 73.04  ? 448 ASP A O     1 
ATOM 1405 C CB    . ASP A 1 454 ? 140.663 154.748 122.728 1.00 72.90  ? 448 ASP A CB    1 
ATOM 1406 C CG    . ASP A 1 454 ? 141.875 155.549 122.260 1.00 79.96  ? 448 ASP A CG    1 
ATOM 1407 O OD1   . ASP A 1 454 ? 142.678 155.056 121.439 1.00 78.94  ? 448 ASP A OD1   1 
ATOM 1408 O OD2   . ASP A 1 454 ? 142.026 156.697 122.729 1.00 80.74  ? 448 ASP A OD2   1 
ATOM 1409 N N     . GLU A 1 455 ? 141.758 153.216 119.934 1.00 64.61  ? 449 GLU A N     1 
ATOM 1410 C CA    . GLU A 1 455 ? 141.852 153.196 118.480 1.00 65.32  ? 449 GLU A CA    1 
ATOM 1411 C C     . GLU A 1 455 ? 140.998 152.083 117.892 1.00 61.50  ? 449 GLU A C     1 
ATOM 1412 O O     . GLU A 1 455 ? 140.350 152.268 116.859 1.00 65.85  ? 449 GLU A O     1 
ATOM 1413 C CB    . GLU A 1 455 ? 143.309 153.047 118.051 1.00 67.67  ? 449 GLU A CB    1 
ATOM 1414 C CG    . GLU A 1 455 ? 144.195 154.194 118.498 1.00 69.96  ? 449 GLU A CG    1 
ATOM 1415 C CD    . GLU A 1 455 ? 143.864 155.493 117.792 1.00 73.07  ? 449 GLU A CD    1 
ATOM 1416 O OE1   . GLU A 1 455 ? 144.446 155.749 116.719 1.00 72.76  ? 449 GLU A OE1   1 
ATOM 1417 O OE2   . GLU A 1 455 ? 143.020 156.256 118.308 1.00 71.57  ? 449 GLU A OE2   1 
ATOM 1418 N N     . THR A 1 456 ? 140.979 150.916 118.540 1.00 47.65  ? 450 THR A N     1 
ATOM 1419 C CA    . THR A 1 456 ? 140.113 149.836 118.079 1.00 43.99  ? 450 THR A CA    1 
ATOM 1420 C C     . THR A 1 456 ? 138.646 150.243 118.144 1.00 49.43  ? 450 THR A C     1 
ATOM 1421 O O     . THR A 1 456 ? 137.879 149.979 117.211 1.00 63.39  ? 450 THR A O     1 
ATOM 1422 C CB    . THR A 1 456 ? 140.363 148.572 118.903 1.00 52.32  ? 450 THR A CB    1 
ATOM 1423 O OG1   . THR A 1 456 ? 141.524 147.898 118.405 1.00 58.01  ? 450 THR A OG1   1 
ATOM 1424 C CG2   . THR A 1 456 ? 139.172 147.634 118.833 1.00 50.29  ? 450 THR A CG2   1 
ATOM 1425 N N     . LYS A 1 457 ? 138.241 150.899 119.233 1.00 51.15  ? 451 LYS A N     1 
ATOM 1426 C CA    . LYS A 1 457 ? 136.851 151.322 119.365 1.00 56.72  ? 451 LYS A CA    1 
ATOM 1427 C C     . LYS A 1 457 ? 136.476 152.357 118.309 1.00 56.47  ? 451 LYS A C     1 
ATOM 1428 O O     . LYS A 1 457 ? 135.409 152.259 117.689 1.00 58.30  ? 451 LYS A O     1 
ATOM 1429 C CB    . LYS A 1 457 ? 136.599 151.872 120.769 1.00 59.83  ? 451 LYS A CB    1 
ATOM 1430 C CG    . LYS A 1 457 ? 136.814 150.855 121.877 1.00 58.67  ? 451 LYS A CG    1 
ATOM 1431 C CD    . LYS A 1 457 ? 136.428 151.422 123.231 1.00 61.32  ? 451 LYS A CD    1 
ATOM 1432 C CE    . LYS A 1 457 ? 137.638 151.548 124.140 1.00 60.37  ? 451 LYS A CE    1 
ATOM 1433 N NZ    . LYS A 1 457 ? 137.245 151.785 125.556 1.00 57.10  ? 451 LYS A NZ    1 
ATOM 1434 N N     . VAL A 1 458 ? 137.339 153.352 118.082 1.00 46.33  ? 452 VAL A N     1 
ATOM 1435 C CA    . VAL A 1 458 ? 137.017 154.372 117.087 1.00 47.94  ? 452 VAL A CA    1 
ATOM 1436 C C     . VAL A 1 458 ? 137.020 153.772 115.685 1.00 52.32  ? 452 VAL A C     1 
ATOM 1437 O O     . VAL A 1 458 ? 136.205 154.149 114.837 1.00 55.69  ? 452 VAL A O     1 
ATOM 1438 C CB    . VAL A 1 458 ? 137.965 155.582 117.204 1.00 47.85  ? 452 VAL A CB    1 
ATOM 1439 C CG1   . VAL A 1 458 ? 139.390 155.207 116.875 1.00 51.69  ? 452 VAL A CG1   1 
ATOM 1440 C CG2   . VAL A 1 458 ? 137.495 156.711 116.300 1.00 50.92  ? 452 VAL A CG2   1 
ATOM 1441 N N     . GLY A 1 459 ? 137.912 152.815 115.421 1.00 48.22  ? 453 GLY A N     1 
ATOM 1442 C CA    . GLY A 1 459 ? 137.916 152.162 114.123 1.00 43.00  ? 453 GLY A CA    1 
ATOM 1443 C C     . GLY A 1 459 ? 136.670 151.335 113.881 1.00 41.20  ? 453 GLY A C     1 
ATOM 1444 O O     . GLY A 1 459 ? 136.114 151.343 112.779 1.00 49.58  ? 453 GLY A O     1 
ATOM 1445 N N     . ARG A 1 460 ? 136.214 150.607 114.904 1.00 28.14  ? 454 ARG A N     1 
ATOM 1446 C CA    . ARG A 1 460 ? 134.969 149.862 114.771 1.00 33.30  ? 454 ARG A CA    1 
ATOM 1447 C C     . ARG A 1 460 ? 133.793 150.803 114.544 1.00 41.78  ? 454 ARG A C     1 
ATOM 1448 O O     . ARG A 1 460 ? 132.926 150.534 113.703 1.00 50.34  ? 454 ARG A O     1 
ATOM 1449 C CB    . ARG A 1 460 ? 134.733 149.001 116.009 1.00 37.47  ? 454 ARG A CB    1 
ATOM 1450 C CG    . ARG A 1 460 ? 133.466 148.169 115.944 1.00 34.54  ? 454 ARG A CG    1 
ATOM 1451 C CD    . ARG A 1 460 ? 132.775 148.109 117.291 1.00 34.22  ? 454 ARG A CD    1 
ATOM 1452 N NE    . ARG A 1 460 ? 131.977 146.900 117.436 1.00 39.44  ? 454 ARG A NE    1 
ATOM 1453 C CZ    . ARG A 1 460 ? 131.458 146.480 118.581 1.00 50.49  ? 454 ARG A CZ    1 
ATOM 1454 N NH1   . ARG A 1 460 ? 131.630 147.154 119.707 1.00 49.68  ? 454 ARG A NH1   1 
ATOM 1455 N NH2   . ARG A 1 460 ? 130.749 145.355 118.600 1.00 42.63  ? 454 ARG A NH2   1 
ATOM 1456 N N     . ALA A 1 461 ? 133.754 151.918 115.278 1.00 37.47  ? 455 ALA A N     1 
ATOM 1457 C CA    . ALA A 1 461 ? 132.674 152.880 115.093 1.00 36.78  ? 455 ALA A CA    1 
ATOM 1458 C C     . ALA A 1 461 ? 132.694 153.469 113.689 1.00 38.93  ? 455 ALA A C     1 
ATOM 1459 O O     . ALA A 1 461 ? 131.638 153.682 113.081 1.00 47.53  ? 455 ALA A O     1 
ATOM 1460 C CB    . ALA A 1 461 ? 132.770 153.986 116.143 1.00 40.82  ? 455 ALA A CB    1 
ATOM 1461 N N     . PHE A 1 462 ? 133.885 153.749 113.160 1.00 40.59  ? 456 PHE A N     1 
ATOM 1462 C CA    . PHE A 1 462 ? 133.994 154.286 111.809 1.00 36.17  ? 456 PHE A CA    1 
ATOM 1463 C C     . PHE A 1 462 ? 133.529 153.272 110.771 1.00 35.86  ? 456 PHE A C     1 
ATOM 1464 O O     . PHE A 1 462 ? 132.707 153.587 109.905 1.00 46.89  ? 456 PHE A O     1 
ATOM 1465 C CB    . PHE A 1 462 ? 135.437 154.709 111.533 1.00 38.38  ? 456 PHE A CB    1 
ATOM 1466 C CG    . PHE A 1 462 ? 135.687 155.138 110.117 1.00 35.47  ? 456 PHE A CG    1 
ATOM 1467 C CD1   . PHE A 1 462 ? 134.931 156.139 109.538 1.00 44.49  ? 456 PHE A CD1   1 
ATOM 1468 C CD2   . PHE A 1 462 ? 136.681 154.540 109.366 1.00 39.18  ? 456 PHE A CD2   1 
ATOM 1469 C CE1   . PHE A 1 462 ? 135.163 156.534 108.236 1.00 47.35  ? 456 PHE A CE1   1 
ATOM 1470 C CE2   . PHE A 1 462 ? 136.918 154.932 108.064 1.00 36.87  ? 456 PHE A CE2   1 
ATOM 1471 C CZ    . PHE A 1 462 ? 136.156 155.930 107.500 1.00 41.00  ? 456 PHE A CZ    1 
ATOM 1472 N N     . PHE A 1 463 ? 134.043 152.042 110.850 1.00 36.09  ? 457 PHE A N     1 
ATOM 1473 C CA    . PHE A 1 463 ? 133.787 151.074 109.787 1.00 34.16  ? 457 PHE A CA    1 
ATOM 1474 C C     . PHE A 1 463 ? 132.376 150.506 109.853 1.00 28.86  ? 457 PHE A C     1 
ATOM 1475 O O     . PHE A 1 463 ? 131.841 150.072 108.827 1.00 35.61  ? 457 PHE A O     1 
ATOM 1476 C CB    . PHE A 1 463 ? 134.821 149.953 109.845 1.00 28.34  ? 457 PHE A CB    1 
ATOM 1477 C CG    . PHE A 1 463 ? 136.162 150.344 109.304 1.00 30.92  ? 457 PHE A CG    1 
ATOM 1478 C CD1   . PHE A 1 463 ? 136.266 151.020 108.103 1.00 33.58  ? 457 PHE A CD1   1 
ATOM 1479 C CD2   . PHE A 1 463 ? 137.319 150.046 109.998 1.00 27.23  ? 457 PHE A CD2   1 
ATOM 1480 C CE1   . PHE A 1 463 ? 137.495 151.387 107.603 1.00 33.52  ? 457 PHE A CE1   1 
ATOM 1481 C CE2   . PHE A 1 463 ? 138.553 150.413 109.503 1.00 30.11  ? 457 PHE A CE2   1 
ATOM 1482 C CZ    . PHE A 1 463 ? 138.640 151.083 108.303 1.00 31.37  ? 457 PHE A CZ    1 
ATOM 1483 N N     . ARG A 1 464 ? 131.757 150.493 111.031 1.00 33.65  ? 458 ARG A N     1 
ATOM 1484 C CA    . ARG A 1 464 ? 130.409 149.954 111.144 1.00 36.64  ? 458 ARG A CA    1 
ATOM 1485 C C     . ARG A 1 464 ? 129.334 150.934 110.694 1.00 41.95  ? 458 ARG A C     1 
ATOM 1486 O O     . ARG A 1 464 ? 128.190 150.519 110.477 1.00 41.95  ? 458 ARG A O     1 
ATOM 1487 C CB    . ARG A 1 464 ? 130.140 149.521 112.588 1.00 39.24  ? 458 ARG A CB    1 
ATOM 1488 C CG    . ARG A 1 464 ? 129.316 150.509 113.392 1.00 40.39  ? 458 ARG A CG    1 
ATOM 1489 C CD    . ARG A 1 464 ? 129.332 150.176 114.868 1.00 42.64  ? 458 ARG A CD    1 
ATOM 1490 N NE    . ARG A 1 464 ? 128.148 150.688 115.545 1.00 51.08  ? 458 ARG A NE    1 
ATOM 1491 C CZ    . ARG A 1 464 ? 127.930 150.589 116.849 1.00 52.39  ? 458 ARG A CZ    1 
ATOM 1492 N NH1   . ARG A 1 464 ? 128.803 150.005 117.653 1.00 46.17  ? 458 ARG A NH1   1 
ATOM 1493 N NH2   . ARG A 1 464 ? 126.810 151.091 117.360 1.00 51.34  ? 458 ARG A NH2   1 
ATOM 1494 N N     . ALA A 1 465 ? 129.671 152.212 110.531 1.00 49.04  ? 459 ALA A N     1 
ATOM 1495 C CA    . ALA A 1 465 ? 128.662 153.222 110.244 1.00 45.14  ? 459 ALA A CA    1 
ATOM 1496 C C     . ALA A 1 465 ? 128.412 153.324 108.743 1.00 43.88  ? 459 ALA A C     1 
ATOM 1497 O O     . ALA A 1 465 ? 129.346 153.186 107.948 1.00 46.61  ? 459 ALA A O     1 
ATOM 1498 C CB    . ALA A 1 465 ? 129.094 154.583 110.780 1.00 39.90  ? 459 ALA A CB    1 
ATOM 1499 N N     . PRO A 1 466 ? 127.163 153.562 108.345 1.00 54.64  ? 460 PRO A N     1 
ATOM 1500 C CA    . PRO A 1 466 ? 126.866 153.767 106.925 1.00 54.49  ? 460 PRO A CA    1 
ATOM 1501 C C     . PRO A 1 466 ? 127.540 155.024 106.398 1.00 57.25  ? 460 PRO A C     1 
ATOM 1502 O O     . PRO A 1 466 ? 127.924 155.921 107.151 1.00 61.09  ? 460 PRO A O     1 
ATOM 1503 C CB    . PRO A 1 466 ? 125.340 153.900 106.899 1.00 51.73  ? 460 PRO A CB    1 
ATOM 1504 C CG    . PRO A 1 466 ? 124.889 153.183 108.126 1.00 51.83  ? 460 PRO A CG    1 
ATOM 1505 C CD    . PRO A 1 466 ? 125.933 153.501 109.152 1.00 53.75  ? 460 PRO A CD    1 
ATOM 1506 N N     . LEU A 1 467 ? 127.688 155.076 105.073 1.00 49.65  ? 461 LEU A N     1 
ATOM 1507 C CA    . LEU A 1 467 ? 128.347 156.216 104.446 1.00 48.71  ? 461 LEU A CA    1 
ATOM 1508 C C     . LEU A 1 467 ? 127.550 157.504 104.599 1.00 50.01  ? 461 LEU A C     1 
ATOM 1509 O O     . LEU A 1 467 ? 128.104 158.587 104.388 1.00 47.44  ? 461 LEU A O     1 
ATOM 1510 C CB    . LEU A 1 467 ? 128.594 155.920 102.969 1.00 49.67  ? 461 LEU A CB    1 
ATOM 1511 C CG    . LEU A 1 467 ? 129.536 154.747 102.704 1.00 46.96  ? 461 LEU A CG    1 
ATOM 1512 C CD1   . LEU A 1 467 ? 129.095 153.980 101.473 1.00 49.28  ? 461 LEU A CD1   1 
ATOM 1513 C CD2   . LEU A 1 467 ? 130.967 155.233 102.551 1.00 46.96  ? 461 LEU A CD2   1 
ATOM 1514 N N     . ASN A 1 468 ? 126.267 157.409 104.950 1.00 63.19  ? 462 ASN A N     1 
ATOM 1515 C CA    . ASN A 1 468 ? 125.476 158.611 105.206 1.00 61.63  ? 462 ASN A CA    1 
ATOM 1516 C C     . ASN A 1 468 ? 126.020 159.385 106.400 1.00 61.72  ? 462 ASN A C     1 
ATOM 1517 O O     . ASN A 1 468 ? 126.126 160.616 106.356 1.00 64.80  ? 462 ASN A O     1 
ATOM 1518 C CB    . ASN A 1 468 ? 124.013 158.235 105.436 1.00 60.25  ? 462 ASN A CB    1 
ATOM 1519 C CG    . ASN A 1 468 ? 123.151 158.482 104.219 1.00 65.91  ? 462 ASN A CG    1 
ATOM 1520 O OD1   . ASN A 1 468 ? 123.559 159.171 103.285 1.00 67.86  ? 462 ASN A OD1   1 
ATOM 1521 N ND2   . ASN A 1 468 ? 121.950 157.919 104.222 1.00 67.83  ? 462 ASN A ND2   1 
ATOM 1522 N N     . GLU A 1 469 ? 126.365 158.682 107.474 1.00 56.74  ? 463 GLU A N     1 
ATOM 1523 C CA    . GLU A 1 469 ? 126.869 159.312 108.681 1.00 56.18  ? 463 GLU A CA    1 
ATOM 1524 C C     . GLU A 1 469 ? 128.344 159.673 108.527 1.00 59.89  ? 463 GLU A C     1 
ATOM 1525 O O     . GLU A 1 469 ? 129.010 159.301 107.556 1.00 61.74  ? 463 GLU A O     1 
ATOM 1526 C CB    . GLU A 1 469 ? 126.667 158.392 109.882 1.00 57.24  ? 463 GLU A CB    1 
ATOM 1527 C CG    . GLU A 1 469 ? 125.354 157.636 109.861 1.00 60.16  ? 463 GLU A CG    1 
ATOM 1528 C CD    . GLU A 1 469 ? 125.111 156.859 111.137 1.00 64.25  ? 463 GLU A CD    1 
ATOM 1529 O OE1   . GLU A 1 469 ? 125.969 156.919 112.041 1.00 61.26  ? 463 GLU A OE1   1 
ATOM 1530 O OE2   . GLU A 1 469 ? 124.062 156.189 111.236 1.00 66.30  ? 463 GLU A OE2   1 
ATOM 1531 N N     . SER A 1 470 ? 128.855 160.417 109.505 1.00 61.23  ? 464 SER A N     1 
ATOM 1532 C CA    . SER A 1 470 ? 130.252 160.834 109.530 1.00 63.04  ? 464 SER A CA    1 
ATOM 1533 C C     . SER A 1 470 ? 130.854 160.449 110.873 1.00 63.55  ? 464 SER A C     1 
ATOM 1534 O O     . SER A 1 470 ? 130.332 160.840 111.923 1.00 65.12  ? 464 SER A O     1 
ATOM 1535 C CB    . SER A 1 470 ? 130.384 162.341 109.291 1.00 60.29  ? 464 SER A CB    1 
ATOM 1536 O OG    . SER A 1 470 ? 131.665 162.665 108.781 1.00 59.78  ? 464 SER A OG    1 
ATOM 1537 N N     . ARG A 1 471 ? 131.944 159.692 110.838 1.00 62.47  ? 465 ARG A N     1 
ATOM 1538 C CA    . ARG A 1 471 ? 132.652 159.253 112.028 1.00 59.97  ? 465 ARG A CA    1 
ATOM 1539 C C     . ARG A 1 471 ? 134.139 159.527 111.874 1.00 62.59  ? 465 ARG A C     1 
ATOM 1540 O O     . ARG A 1 471 ? 134.660 159.529 110.755 1.00 63.35  ? 465 ARG A O     1 
ATOM 1541 C CB    . ARG A 1 471 ? 132.429 157.756 112.289 1.00 58.83  ? 465 ARG A CB    1 
ATOM 1542 C CG    . ARG A 1 471 ? 131.423 157.454 113.388 1.00 60.53  ? 465 ARG A CG    1 
ATOM 1543 C CD    . ARG A 1 471 ? 130.011 157.816 112.973 1.00 62.82  ? 465 ARG A CD    1 
ATOM 1544 N NE    . ARG A 1 471 ? 129.054 157.562 114.041 1.00 68.02  ? 465 ARG A NE    1 
ATOM 1545 C CZ    . ARG A 1 471 ? 127.832 158.075 114.089 1.00 68.63  ? 465 ARG A CZ    1 
ATOM 1546 N NH1   . ARG A 1 471 ? 127.378 158.870 113.134 1.00 61.51  ? 465 ARG A NH1   1 
ATOM 1547 N NH2   . ARG A 1 471 ? 127.044 157.780 115.119 1.00 68.16  ? 465 ARG A NH2   1 
ATOM 1548 N N     . PRO A 1 472 ? 134.845 159.765 112.978 1.00 61.32  ? 466 PRO A N     1 
ATOM 1549 C CA    . PRO A 1 472 ? 136.283 160.030 112.886 1.00 58.57  ? 466 PRO A CA    1 
ATOM 1550 C C     . PRO A 1 472 ? 137.052 158.817 112.385 1.00 61.24  ? 466 PRO A C     1 
ATOM 1551 O O     . PRO A 1 472 ? 136.677 157.668 112.628 1.00 61.22  ? 466 PRO A O     1 
ATOM 1552 C CB    . PRO A 1 472 ? 136.676 160.375 114.329 1.00 58.61  ? 466 PRO A CB    1 
ATOM 1553 C CG    . PRO A 1 472 ? 135.394 160.740 115.003 1.00 61.79  ? 466 PRO A CG    1 
ATOM 1554 C CD    . PRO A 1 472 ? 134.349 159.894 114.358 1.00 60.59  ? 466 PRO A CD    1 
ATOM 1555 N N     . LYS A 1 473 ? 138.140 159.092 111.674 1.00 52.86  ? 467 LYS A N     1 
ATOM 1556 C CA    . LYS A 1 473 ? 138.977 158.025 111.158 1.00 49.17  ? 467 LYS A CA    1 
ATOM 1557 C C     . LYS A 1 473 ? 139.738 157.347 112.297 1.00 50.39  ? 467 LYS A C     1 
ATOM 1558 O O     . LYS A 1 473 ? 139.996 157.964 113.334 1.00 56.00  ? 467 LYS A O     1 
ATOM 1559 C CB    . LYS A 1 473 ? 139.959 158.571 110.125 1.00 48.40  ? 467 LYS A CB    1 
ATOM 1560 C CG    . LYS A 1 473 ? 139.483 158.431 108.692 1.00 48.68  ? 467 LYS A CG    1 
ATOM 1561 C CD    . LYS A 1 473 ? 140.585 158.774 107.710 1.00 49.73  ? 467 LYS A CD    1 
ATOM 1562 C CE    . LYS A 1 473 ? 140.268 160.059 106.967 1.00 55.46  ? 467 LYS A CE    1 
ATOM 1563 N NZ    . LYS A 1 473 ? 141.301 160.375 105.942 1.00 53.52  ? 467 LYS A NZ    1 
ATOM 1564 N N     . PRO A 1 474 ? 140.089 156.068 112.136 1.00 52.31  ? 468 PRO A N     1 
ATOM 1565 C CA    . PRO A 1 474 ? 140.862 155.387 113.189 1.00 55.56  ? 468 PRO A CA    1 
ATOM 1566 C C     . PRO A 1 474 ? 142.188 156.058 113.498 1.00 59.40  ? 468 PRO A C     1 
ATOM 1567 O O     . PRO A 1 474 ? 142.589 156.110 114.667 1.00 62.08  ? 468 PRO A O     1 
ATOM 1568 C CB    . PRO A 1 474 ? 141.062 153.981 112.612 1.00 52.13  ? 468 PRO A CB    1 
ATOM 1569 C CG    . PRO A 1 474 ? 139.930 153.793 111.681 1.00 48.62  ? 468 PRO A CG    1 
ATOM 1570 C CD    . PRO A 1 474 ? 139.642 155.137 111.088 1.00 53.18  ? 468 PRO A CD    1 
ATOM 1571 N N     . LYS A 1 475 ? 142.876 156.580 112.480 1.00 61.07  ? 469 LYS A N     1 
ATOM 1572 C CA    . LYS A 1 475 ? 144.180 157.224 112.649 1.00 65.39  ? 469 LYS A CA    1 
ATOM 1573 C C     . LYS A 1 475 ? 145.161 156.252 113.316 1.00 69.27  ? 469 LYS A C     1 
ATOM 1574 O O     . LYS A 1 475 ? 145.930 156.603 114.211 1.00 65.65  ? 469 LYS A O     1 
ATOM 1575 C CB    . LYS A 1 475 ? 144.026 158.546 113.421 1.00 65.72  ? 469 LYS A CB    1 
ATOM 1576 C CG    . LYS A 1 475 ? 145.298 159.314 113.803 1.00 64.69  ? 469 LYS A CG    1 
ATOM 1577 C CD    . LYS A 1 475 ? 145.109 160.827 113.713 1.00 65.87  ? 469 LYS A CD    1 
ATOM 1578 C CE    . LYS A 1 475 ? 143.934 161.348 114.547 1.00 66.00  ? 469 LYS A CE    1 
ATOM 1579 N NZ    . LYS A 1 475 ? 143.620 160.538 115.761 1.00 66.93  ? 469 LYS A NZ    1 
ATOM 1580 N N     . ASP A 1 476 ? 145.109 154.994 112.885 1.00 72.49  ? 470 ASP A N     1 
ATOM 1581 C CA    . ASP A 1 476 ? 146.026 153.975 113.378 1.00 70.57  ? 470 ASP A CA    1 
ATOM 1582 C C     . ASP A 1 476 ? 146.087 152.841 112.367 1.00 65.34  ? 470 ASP A C     1 
ATOM 1583 O O     . ASP A 1 476 ? 145.225 152.714 111.494 1.00 63.51  ? 470 ASP A O     1 
ATOM 1584 C CB    . ASP A 1 476 ? 145.604 153.448 114.754 1.00 69.30  ? 470 ASP A CB    1 
ATOM 1585 C CG    . ASP A 1 476 ? 146.787 153.003 115.593 1.00 76.21  ? 470 ASP A CG    1 
ATOM 1586 O OD1   . ASP A 1 476 ? 146.662 152.967 116.835 1.00 73.52  ? 470 ASP A OD1   1 
ATOM 1587 O OD2   . ASP A 1 476 ? 147.848 152.691 115.011 1.00 77.44  ? 470 ASP A OD2   1 
ATOM 1588 N N     . LYS A 1 477 ? 147.126 152.018 112.499 1.00 55.47  ? 471 LYS A N     1 
ATOM 1589 C CA    . LYS A 1 477 ? 147.334 150.871 111.617 1.00 56.90  ? 471 LYS A CA    1 
ATOM 1590 C C     . LYS A 1 477 ? 146.738 149.638 112.291 1.00 54.91  ? 471 LYS A C     1 
ATOM 1591 O O     . LYS A 1 477 ? 147.437 148.808 112.873 1.00 53.70  ? 471 LYS A O     1 
ATOM 1592 C CB    . LYS A 1 477 ? 148.816 150.696 111.306 1.00 58.33  ? 471 LYS A CB    1 
ATOM 1593 C CG    . LYS A 1 477 ? 149.432 151.868 110.562 1.00 59.46  ? 471 LYS A CG    1 
ATOM 1594 C CD    . LYS A 1 477 ? 150.437 151.395 109.524 1.00 61.91  ? 471 LYS A CD    1 
ATOM 1595 C CE    . LYS A 1 477 ? 151.447 152.483 109.195 1.00 59.15  ? 471 LYS A CE    1 
ATOM 1596 N NZ    . LYS A 1 477 ? 151.224 153.061 107.840 1.00 57.80  ? 471 LYS A NZ    1 
ATOM 1597 N N     . LEU A 1 478 ? 145.415 149.528 112.204 1.00 52.93  ? 472 LEU A N     1 
ATOM 1598 C CA    . LEU A 1 478 ? 144.701 148.415 112.809 1.00 46.36  ? 472 LEU A CA    1 
ATOM 1599 C C     . LEU A 1 478 ? 144.889 147.147 111.980 1.00 54.71  ? 472 LEU A C     1 
ATOM 1600 O O     . LEU A 1 478 ? 145.586 147.127 110.962 1.00 62.05  ? 472 LEU A O     1 
ATOM 1601 C CB    . LEU A 1 478 ? 143.217 148.748 112.946 1.00 46.40  ? 472 LEU A CB    1 
ATOM 1602 C CG    . LEU A 1 478 ? 142.844 149.991 113.753 1.00 49.94  ? 472 LEU A CG    1 
ATOM 1603 C CD1   . LEU A 1 478 ? 141.335 150.115 113.855 1.00 44.34  ? 472 LEU A CD1   1 
ATOM 1604 C CD2   . LEU A 1 478 ? 143.474 149.939 115.134 1.00 56.15  ? 472 LEU A CD2   1 
ATOM 1605 N N     . THR A 1 479 ? 144.253 146.069 112.430 1.00 39.26  ? 473 THR A N     1 
ATOM 1606 C CA    . THR A 1 479 ? 144.237 144.805 111.709 1.00 28.09  ? 473 THR A CA    1 
ATOM 1607 C C     . THR A 1 479 ? 142.817 144.260 111.711 1.00 34.74  ? 473 THR A C     1 
ATOM 1608 O O     . THR A 1 479 ? 142.146 144.270 112.748 1.00 44.83  ? 473 THR A O     1 
ATOM 1609 C CB    . THR A 1 479 ? 145.205 143.795 112.330 1.00 36.29  ? 473 THR A CB    1 
ATOM 1610 O OG1   . THR A 1 479 ? 146.477 144.419 112.540 1.00 43.11  ? 473 THR A OG1   1 
ATOM 1611 C CG2   . THR A 1 479 ? 145.391 142.598 111.411 1.00 34.57  ? 473 THR A CG2   1 
ATOM 1612 N N     . VAL A 1 480 ? 142.365 143.788 110.551 1.00 34.22  ? 474 VAL A N     1 
ATOM 1613 C CA    . VAL A 1 480 ? 140.995 143.333 110.357 1.00 29.20  ? 474 VAL A CA    1 
ATOM 1614 C C     . VAL A 1 480 ? 141.019 141.896 109.856 1.00 35.24  ? 474 VAL A C     1 
ATOM 1615 O O     . VAL A 1 480 ? 141.778 141.560 108.937 1.00 32.56  ? 474 VAL A O     1 
ATOM 1616 C CB    . VAL A 1 480 ? 140.225 144.242 109.382 1.00 32.34  ? 474 VAL A CB    1 
ATOM 1617 C CG1   . VAL A 1 480 ? 138.735 143.954 109.452 1.00 34.75  ? 474 VAL A CG1   1 
ATOM 1618 C CG2   . VAL A 1 480 ? 140.498 145.703 109.694 1.00 32.78  ? 474 VAL A CG2   1 
ATOM 1619 N N     . MET A 1 481 ? 140.185 141.057 110.466 1.00 36.16  ? 475 MET A N     1 
ATOM 1620 C CA    . MET A 1 481 ? 140.064 139.637 110.152 1.00 35.18  ? 475 MET A CA    1 
ATOM 1621 C C     . MET A 1 481 ? 138.663 139.384 109.616 1.00 34.80  ? 475 MET A C     1 
ATOM 1622 O O     . MET A 1 481 ? 137.688 139.471 110.366 1.00 48.87  ? 475 MET A O     1 
ATOM 1623 C CB    . MET A 1 481 ? 140.310 138.790 111.401 1.00 36.16  ? 475 MET A CB    1 
ATOM 1624 C CG    . MET A 1 481 ? 139.968 137.320 111.240 1.00 35.16  ? 475 MET A CG    1 
ATOM 1625 S SD    . MET A 1 481 ? 140.998 136.210 112.212 1.00 55.34  ? 475 MET A SD    1 
ATOM 1626 C CE    . MET A 1 481 ? 142.541 136.309 111.334 1.00 33.40  ? 475 MET A CE    1 
ATOM 1627 N N     . GLY A 1 482 ? 138.552 139.062 108.329 1.00 21.08  ? 476 GLY A N     1 
ATOM 1628 C CA    . GLY A 1 482 ? 137.279 138.667 107.756 1.00 16.46  ? 476 GLY A CA    1 
ATOM 1629 C C     . GLY A 1 482 ? 137.103 137.169 107.889 1.00 22.90  ? 476 GLY A C     1 
ATOM 1630 O O     . GLY A 1 482 ? 137.997 136.400 107.529 1.00 37.79  ? 476 GLY A O     1 
ATOM 1631 N N     . ILE A 1 483 ? 135.949 136.757 108.417 1.00 27.09  ? 477 ILE A N     1 
ATOM 1632 C CA    . ILE A 1 483 ? 135.720 135.361 108.780 1.00 30.05  ? 477 ILE A CA    1 
ATOM 1633 C C     . ILE A 1 483 ? 134.438 134.859 108.122 1.00 31.61  ? 477 ILE A C     1 
ATOM 1634 O O     . ILE A 1 483 ? 133.395 135.518 108.197 1.00 44.81  ? 477 ILE A O     1 
ATOM 1635 C CB    . ILE A 1 483 ? 135.653 135.181 110.310 1.00 22.28  ? 477 ILE A CB    1 
ATOM 1636 C CG1   . ILE A 1 483 ? 137.051 134.942 110.875 1.00 34.78  ? 477 ILE A CG1   1 
ATOM 1637 C CG2   . ILE A 1 483 ? 134.745 134.027 110.693 1.00 14.08  ? 477 ILE A CG2   1 
ATOM 1638 C CD1   . ILE A 1 483 ? 137.198 135.352 112.315 1.00 39.66  ? 477 ILE A CD1   1 
ATOM 1639 N N     . ASP A 1 484 ? 134.524 133.692 107.482 1.00 25.39  ? 478 ASP A N     1 
ATOM 1640 C CA    . ASP A 1 484 ? 133.371 132.951 106.976 1.00 22.91  ? 478 ASP A CA    1 
ATOM 1641 C C     . ASP A 1 484 ? 133.215 131.674 107.786 1.00 42.88  ? 478 ASP A C     1 
ATOM 1642 O O     . ASP A 1 484 ? 134.195 130.956 108.006 1.00 55.49  ? 478 ASP A O     1 
ATOM 1643 C CB    . ASP A 1 484 ? 133.529 132.601 105.497 1.00 28.91  ? 478 ASP A CB    1 
ATOM 1644 C CG    . ASP A 1 484 ? 132.236 132.111 104.881 1.00 49.49  ? 478 ASP A CG    1 
ATOM 1645 O OD1   . ASP A 1 484 ? 132.258 131.646 103.724 1.00 50.37  ? 478 ASP A OD1   1 
ATOM 1646 O OD2   . ASP A 1 484 ? 131.189 132.202 105.554 1.00 56.73  ? 478 ASP A OD2   1 
ATOM 1647 N N     . LEU A 1 485 ? 131.990 131.380 108.210 1.00 39.80  ? 479 LEU A N     1 
ATOM 1648 C CA    . LEU A 1 485 ? 131.726 130.196 109.013 1.00 32.77  ? 479 LEU A CA    1 
ATOM 1649 C C     . LEU A 1 485 ? 130.981 129.133 108.213 1.00 42.03  ? 479 LEU A C     1 
ATOM 1650 O O     . LEU A 1 485 ? 130.027 129.421 107.488 1.00 48.91  ? 479 LEU A O     1 
ATOM 1651 C CB    . LEU A 1 485 ? 130.916 130.565 110.255 1.00 32.66  ? 479 LEU A CB    1 
ATOM 1652 C CG    . LEU A 1 485 ? 131.575 131.555 111.210 1.00 36.43  ? 479 LEU A CG    1 
ATOM 1653 C CD1   . LEU A 1 485 ? 130.516 132.311 111.986 1.00 41.31  ? 479 LEU A CD1   1 
ATOM 1654 C CD2   . LEU A 1 485 ? 132.526 130.839 112.150 1.00 36.61  ? 479 LEU A CD2   1 
ATOM 1655 N N     . GLY A 1 486 ? 131.420 127.889 108.372 1.00 40.24  ? 480 GLY A N     1 
ATOM 1656 C CA    . GLY A 1 486 ? 130.784 126.760 107.733 1.00 44.32  ? 480 GLY A CA    1 
ATOM 1657 C C     . GLY A 1 486 ? 130.964 125.516 108.575 1.00 47.28  ? 480 GLY A C     1 
ATOM 1658 O O     . GLY A 1 486 ? 131.397 125.584 109.726 1.00 43.72  ? 480 GLY A O     1 
ATOM 1659 N N     . ILE A 1 487 ? 130.621 124.372 107.993 1.00 44.64  ? 481 ILE A N     1 
ATOM 1660 C CA    . ILE A 1 487 ? 130.780 123.088 108.672 1.00 39.83  ? 481 ILE A CA    1 
ATOM 1661 C C     . ILE A 1 487 ? 131.857 122.230 108.020 1.00 46.49  ? 481 ILE A C     1 
ATOM 1662 O O     . ILE A 1 487 ? 132.626 121.566 108.714 1.00 52.25  ? 481 ILE A O     1 
ATOM 1663 C CB    . ILE A 1 487 ? 129.431 122.335 108.766 1.00 41.91  ? 481 ILE A CB    1 
ATOM 1664 C CG1   . ILE A 1 487 ? 129.045 121.671 107.444 1.00 43.40  ? 481 ILE A CG1   1 
ATOM 1665 C CG2   . ILE A 1 487 ? 128.337 123.271 109.221 1.00 50.15  ? 481 ILE A CG2   1 
ATOM 1666 C CD1   . ILE A 1 487 ? 128.032 120.566 107.607 1.00 48.26  ? 481 ILE A CD1   1 
ATOM 1667 N N     . ASN A 1 488 ? 131.941 122.221 106.688 1.00 51.54  ? 482 ASN A N     1 
ATOM 1668 C CA    . ASN A 1 488 ? 133.015 121.430 106.104 1.00 49.79  ? 482 ASN A CA    1 
ATOM 1669 C C     . ASN A 1 488 ? 134.319 122.216 106.234 1.00 52.52  ? 482 ASN A C     1 
ATOM 1670 O O     . ASN A 1 488 ? 135.256 121.721 106.871 1.00 62.94  ? 482 ASN A O     1 
ATOM 1671 C CB    . ASN A 1 488 ? 132.701 121.031 104.660 1.00 41.02  ? 482 ASN A CB    1 
ATOM 1672 C CG    . ASN A 1 488 ? 133.443 119.789 104.229 1.00 47.87  ? 482 ASN A CG    1 
ATOM 1673 O OD1   . ASN A 1 488 ? 134.673 119.760 104.213 1.00 48.89  ? 482 ASN A OD1   1 
ATOM 1674 N ND2   . ASN A 1 488 ? 132.699 118.749 103.877 1.00 50.67  ? 482 ASN A ND2   1 
ATOM 1675 N N     . PRO A 1 489 ? 134.440 123.439 105.670 1.00 48.50  ? 483 PRO A N     1 
ATOM 1676 C CA    . PRO A 1 489 ? 135.512 124.328 106.126 1.00 45.73  ? 483 PRO A CA    1 
ATOM 1677 C C     . PRO A 1 489 ? 135.065 125.086 107.361 1.00 48.04  ? 483 PRO A C     1 
ATOM 1678 O O     . PRO A 1 489 ? 134.523 126.186 107.225 1.00 58.88  ? 483 PRO A O     1 
ATOM 1679 C CB    . PRO A 1 489 ? 135.741 125.266 104.931 1.00 42.30  ? 483 PRO A CB    1 
ATOM 1680 C CG    . PRO A 1 489 ? 134.838 124.757 103.835 1.00 53.71  ? 483 PRO A CG    1 
ATOM 1681 C CD    . PRO A 1 489 ? 133.727 124.065 104.546 1.00 50.72  ? 483 PRO A CD    1 
ATOM 1682 N N     . ALA A 1 490 ? 135.248 124.492 108.548 1.00 30.64  ? 484 ALA A N     1 
ATOM 1683 C CA    . ALA A 1 490 ? 134.703 125.026 109.798 1.00 27.19  ? 484 ALA A CA    1 
ATOM 1684 C C     . ALA A 1 490 ? 134.714 126.549 109.847 1.00 37.64  ? 484 ALA A C     1 
ATOM 1685 O O     . ALA A 1 490 ? 133.717 127.174 110.224 1.00 44.34  ? 484 ALA A O     1 
ATOM 1686 C CB    . ALA A 1 490 ? 135.481 124.451 110.983 1.00 33.68  ? 484 ALA A CB    1 
ATOM 1687 N N     . PHE A 1 491 ? 135.834 127.162 109.468 1.00 37.12  ? 485 PHE A N     1 
ATOM 1688 C CA    . PHE A 1 491 ? 135.850 128.587 109.168 1.00 25.20  ? 485 PHE A CA    1 
ATOM 1689 C C     . PHE A 1 491 ? 137.061 128.903 108.304 1.00 24.33  ? 485 PHE A C     1 
ATOM 1690 O O     . PHE A 1 491 ? 138.037 128.150 108.279 1.00 35.25  ? 485 PHE A O     1 
ATOM 1691 C CB    . PHE A 1 491 ? 135.840 129.446 110.443 1.00 25.09  ? 485 PHE A CB    1 
ATOM 1692 C CG    . PHE A 1 491 ? 137.162 129.522 111.149 1.00 26.65  ? 485 PHE A CG    1 
ATOM 1693 C CD1   . PHE A 1 491 ? 137.516 128.566 112.084 1.00 27.12  ? 485 PHE A CD1   1 
ATOM 1694 C CD2   . PHE A 1 491 ? 138.035 130.568 110.906 1.00 27.98  ? 485 PHE A CD2   1 
ATOM 1695 C CE1   . PHE A 1 491 ? 138.722 128.641 112.743 1.00 25.44  ? 485 PHE A CE1   1 
ATOM 1696 C CE2   . PHE A 1 491 ? 139.243 130.644 111.561 1.00 28.67  ? 485 PHE A CE2   1 
ATOM 1697 C CZ    . PHE A 1 491 ? 139.585 129.680 112.481 1.00 28.35  ? 485 PHE A CZ    1 
ATOM 1698 N N     . ALA A 1 492 ? 136.973 130.019 107.583 1.00 25.45  ? 486 ALA A N     1 
ATOM 1699 C CA    . ALA A 1 492 ? 138.055 130.532 106.756 1.00 20.47  ? 486 ALA A CA    1 
ATOM 1700 C C     . ALA A 1 492 ? 138.231 132.015 107.040 1.00 22.78  ? 486 ALA A C     1 
ATOM 1701 O O     . ALA A 1 492 ? 137.276 132.706 107.405 1.00 38.82  ? 486 ALA A O     1 
ATOM 1702 C CB    . ALA A 1 492 ? 137.778 130.313 105.267 1.00 25.10  ? 486 ALA A CB    1 
ATOM 1703 N N     . PHE A 1 493 ? 139.457 132.510 106.869 1.00 26.16  ? 487 PHE A N     1 
ATOM 1704 C CA    . PHE A 1 493 ? 139.781 133.860 107.307 1.00 22.50  ? 487 PHE A CA    1 
ATOM 1705 C C     . PHE A 1 493 ? 140.674 134.560 106.293 1.00 34.65  ? 487 PHE A C     1 
ATOM 1706 O O     . PHE A 1 493 ? 141.387 133.929 105.506 1.00 44.97  ? 487 PHE A O     1 
ATOM 1707 C CB    . PHE A 1 493 ? 140.450 133.847 108.688 1.00 22.23  ? 487 PHE A CB    1 
ATOM 1708 C CG    . PHE A 1 493 ? 141.850 133.304 108.681 1.00 29.83  ? 487 PHE A CG    1 
ATOM 1709 C CD1   . PHE A 1 493 ? 142.937 134.149 108.539 1.00 29.22  ? 487 PHE A CD1   1 
ATOM 1710 C CD2   . PHE A 1 493 ? 142.080 131.950 108.817 1.00 36.14  ? 487 PHE A CD2   1 
ATOM 1711 C CE1   . PHE A 1 493 ? 144.220 133.651 108.528 1.00 29.84  ? 487 PHE A CE1   1 
ATOM 1712 C CE2   . PHE A 1 493 ? 143.363 131.446 108.808 1.00 36.76  ? 487 PHE A CE2   1 
ATOM 1713 C CZ    . PHE A 1 493 ? 144.433 132.298 108.664 1.00 33.05  ? 487 PHE A CZ    1 
ATOM 1714 N N     . ALA A 1 494 ? 140.616 135.891 106.331 1.00 33.68  ? 488 ALA A N     1 
ATOM 1715 C CA    . ALA A 1 494 ? 141.510 136.759 105.571 1.00 27.14  ? 488 ALA A CA    1 
ATOM 1716 C C     . ALA A 1 494 ? 141.943 137.907 106.471 1.00 36.79  ? 488 ALA A C     1 
ATOM 1717 O O     . ALA A 1 494 ? 141.150 138.379 107.288 1.00 49.71  ? 488 ALA A O     1 
ATOM 1718 C CB    . ALA A 1 494 ? 140.829 137.295 104.310 1.00 25.47  ? 488 ALA A CB    1 
ATOM 1719 N N     . VAL A 1 495 ? 143.186 138.360 106.319 1.00 38.24  ? 489 VAL A N     1 
ATOM 1720 C CA    . VAL A 1 495 ? 143.784 139.353 107.206 1.00 40.75  ? 489 VAL A CA    1 
ATOM 1721 C C     . VAL A 1 495 ? 144.202 140.566 106.386 1.00 49.73  ? 489 VAL A C     1 
ATOM 1722 O O     . VAL A 1 495 ? 144.854 140.421 105.347 1.00 54.73  ? 489 VAL A O     1 
ATOM 1723 C CB    . VAL A 1 495 ? 144.996 138.779 107.961 1.00 40.38  ? 489 VAL A CB    1 
ATOM 1724 C CG1   . VAL A 1 495 ? 145.745 139.879 108.694 1.00 36.44  ? 489 VAL A CG1   1 
ATOM 1725 C CG2   . VAL A 1 495 ? 144.558 137.704 108.918 1.00 46.40  ? 489 VAL A CG2   1 
ATOM 1726 N N     . CYS A 1 496 ? 143.841 141.760 106.859 1.00 37.82  ? 490 CYS A N     1 
ATOM 1727 C CA    . CYS A 1 496 ? 144.267 143.001 106.227 1.00 31.90  ? 490 CYS A CA    1 
ATOM 1728 C C     . CYS A 1 496 ? 144.776 143.975 107.279 1.00 43.98  ? 490 CYS A C     1 
ATOM 1729 O O     . CYS A 1 496 ? 144.318 143.973 108.424 1.00 59.63  ? 490 CYS A O     1 
ATOM 1730 C CB    . CYS A 1 496 ? 143.134 143.653 105.427 1.00 40.88  ? 490 CYS A CB    1 
ATOM 1731 S SG    . CYS A 1 496 ? 142.103 144.786 106.373 1.00 46.74  ? 490 CYS A SG    1 
ATOM 1732 N N     . THR A 1 497 ? 145.741 144.801 106.882 1.00 49.00  ? 491 THR A N     1 
ATOM 1733 C CA    . THR A 1 497 ? 146.319 145.822 107.745 1.00 45.93  ? 491 THR A CA    1 
ATOM 1734 C C     . THR A 1 497 ? 146.143 147.185 107.092 1.00 51.44  ? 491 THR A C     1 
ATOM 1735 O O     . THR A 1 497 ? 146.524 147.372 105.932 1.00 60.84  ? 491 THR A O     1 
ATOM 1736 C CB    . THR A 1 497 ? 147.801 145.553 108.005 1.00 50.28  ? 491 THR A CB    1 
ATOM 1737 O OG1   . THR A 1 497 ? 147.978 144.187 108.398 1.00 58.52  ? 491 THR A OG1   1 
ATOM 1738 C CG2   . THR A 1 497 ? 148.323 146.462 109.104 1.00 51.32  ? 491 THR A CG2   1 
ATOM 1739 N N     . LEU A 1 498 ? 145.576 148.132 107.836 1.00 46.71  ? 492 LEU A N     1 
ATOM 1740 C CA    . LEU A 1 498 ? 145.303 149.451 107.281 1.00 52.97  ? 492 LEU A CA    1 
ATOM 1741 C C     . LEU A 1 498 ? 146.599 150.182 106.948 1.00 61.05  ? 492 LEU A C     1 
ATOM 1742 O O     . LEU A 1 498 ? 147.580 150.116 107.693 1.00 63.91  ? 492 LEU A O     1 
ATOM 1743 C CB    . LEU A 1 498 ? 144.473 150.285 108.256 1.00 47.78  ? 492 LEU A CB    1 
ATOM 1744 C CG    . LEU A 1 498 ? 142.946 150.205 108.168 1.00 48.27  ? 492 LEU A CG    1 
ATOM 1745 C CD1   . LEU A 1 498 ? 142.460 148.799 107.853 1.00 49.65  ? 492 LEU A CD1   1 
ATOM 1746 C CD2   . LEU A 1 498 ? 142.316 150.715 109.451 1.00 52.90  ? 492 LEU A CD2   1 
ATOM 1747 N N     . GLY A 1 499 ? 146.592 150.885 105.821 1.00 61.53  ? 493 GLY A N     1 
ATOM 1748 C CA    . GLY A 1 499 ? 147.770 151.620 105.390 1.00 64.91  ? 493 GLY A CA    1 
ATOM 1749 C C     . GLY A 1 499 ? 148.973 150.744 105.122 1.00 67.46  ? 493 GLY A C     1 
ATOM 1750 O O     . GLY A 1 499 ? 150.109 151.150 105.393 1.00 69.06  ? 493 GLY A O     1 
ATOM 1751 N N     . GLU A 1 500 ? 148.751 149.544 104.588 1.00 70.33  ? 494 GLU A N     1 
ATOM 1752 C CA    . GLU A 1 500 ? 149.846 148.623 104.304 1.00 69.99  ? 494 GLU A CA    1 
ATOM 1753 C C     . GLU A 1 500 ? 149.398 147.702 103.177 1.00 69.87  ? 494 GLU A C     1 
ATOM 1754 O O     . GLU A 1 500 ? 148.607 146.782 103.412 1.00 72.44  ? 494 GLU A O     1 
ATOM 1755 C CB    . GLU A 1 500 ? 150.229 147.834 105.551 1.00 72.01  ? 494 GLU A CB    1 
ATOM 1756 C CG    . GLU A 1 500 ? 151.389 146.875 105.356 1.00 75.95  ? 494 GLU A CG    1 
ATOM 1757 C CD    . GLU A 1 500 ? 152.257 146.748 106.592 1.00 77.56  ? 494 GLU A CD    1 
ATOM 1758 O OE1   . GLU A 1 500 ? 152.971 147.718 106.923 1.00 75.10  ? 494 GLU A OE1   1 
ATOM 1759 O OE2   . GLU A 1 500 ? 152.226 145.678 107.233 1.00 74.94  ? 494 GLU A OE2   1 
ATOM 1760 N N     . CYS A 1 501 ? 149.900 147.944 101.971 1.00 70.81  ? 495 CYS A N     1 
ATOM 1761 C CA    . CYS A 1 501 ? 149.477 147.210 100.781 1.00 72.51  ? 495 CYS A CA    1 
ATOM 1762 C C     . CYS A 1 501 ? 150.718 146.771 100.016 1.00 74.81  ? 495 CYS A C     1 
ATOM 1763 O O     . CYS A 1 501 ? 151.396 147.603 99.405  1.00 79.19  ? 495 CYS A O     1 
ATOM 1764 C CB    . CYS A 1 501 ? 148.572 148.072 99.901  1.00 69.63  ? 495 CYS A CB    1 
ATOM 1765 S SG    . CYS A 1 501 ? 147.468 147.149 98.815  1.00 81.52  ? 495 CYS A SG    1 
ATOM 1766 N N     . GLN A 1 502 ? 151.017 145.471 100.047 1.00 72.45  ? 496 GLN A N     1 
ATOM 1767 C CA    . GLN A 1 502 ? 152.170 144.923 99.343  1.00 72.98  ? 496 GLN A CA    1 
ATOM 1768 C C     . GLN A 1 502 ? 151.769 143.971 98.223  1.00 73.68  ? 496 GLN A C     1 
ATOM 1769 O O     . GLN A 1 502 ? 152.125 144.199 97.063  1.00 71.83  ? 496 GLN A O     1 
ATOM 1770 C CB    . GLN A 1 502 ? 153.103 144.213 100.335 1.00 72.19  ? 496 GLN A CB    1 
ATOM 1771 C CG    . GLN A 1 502 ? 152.384 143.452 101.433 1.00 76.41  ? 496 GLN A CG    1 
ATOM 1772 C CD    . GLN A 1 502 ? 152.325 144.234 102.727 1.00 78.07  ? 496 GLN A CD    1 
ATOM 1773 O OE1   . GLN A 1 502 ? 152.369 145.462 102.719 1.00 72.92  ? 496 GLN A OE1   1 
ATOM 1774 N NE2   . GLN A 1 502 ? 152.223 143.525 103.845 1.00 78.10  ? 496 GLN A NE2   1 
ATOM 1775 N N     . ASP A 1 503 ? 151.024 142.913 98.535  1.00 77.34  ? 497 ASP A N     1 
ATOM 1776 C CA    . ASP A 1 503 ? 150.653 141.920 97.535  1.00 77.94  ? 497 ASP A CA    1 
ATOM 1777 C C     . ASP A 1 503 ? 149.498 141.057 98.023  1.00 77.23  ? 497 ASP A C     1 
ATOM 1778 O O     . ASP A 1 503 ? 149.502 140.584 99.164  1.00 72.49  ? 497 ASP A O     1 
ATOM 1779 C CB    . ASP A 1 503 ? 151.851 141.039 97.177  1.00 77.23  ? 497 ASP A CB    1 
ATOM 1780 C CG    . ASP A 1 503 ? 151.528 140.031 96.092  1.00 78.64  ? 497 ASP A CG    1 
ATOM 1781 O OD1   . ASP A 1 503 ? 150.771 140.380 95.162  1.00 76.69  ? 497 ASP A OD1   1 
ATOM 1782 O OD2   . ASP A 1 503 ? 152.034 138.892 96.167  1.00 76.49  ? 497 ASP A OD2   1 
ATOM 1783 N N     . GLY A 1 504 ? 148.514 140.848 97.168  1.00 65.85  ? 498 GLY A N     1 
ATOM 1784 C CA    . GLY A 1 504 ? 147.350 140.063 97.516  1.00 60.30  ? 498 GLY A CA    1 
ATOM 1785 C C     . GLY A 1 504 ? 146.118 140.658 96.868  1.00 58.58  ? 498 GLY A C     1 
ATOM 1786 O O     . GLY A 1 504 ? 146.203 141.559 96.040  1.00 60.43  ? 498 GLY A O     1 
ATOM 1787 N N     . ILE A 1 505 ? 144.964 140.133 97.269  1.00 45.67  ? 499 ILE A N     1 
ATOM 1788 C CA    . ILE A 1 505 ? 143.696 140.628 96.751  1.00 45.66  ? 499 ILE A CA    1 
ATOM 1789 C C     . ILE A 1 505 ? 143.458 142.014 97.328  1.00 43.60  ? 499 ILE A C     1 
ATOM 1790 O O     . ILE A 1 505 ? 143.095 142.158 98.500  1.00 50.16  ? 499 ILE A O     1 
ATOM 1791 C CB    . ILE A 1 505 ? 142.537 139.671 97.087  1.00 47.82  ? 499 ILE A CB    1 
ATOM 1792 C CG1   . ILE A 1 505 ? 142.749 138.319 96.405  1.00 50.21  ? 499 ILE A CG1   1 
ATOM 1793 C CG2   . ILE A 1 505 ? 141.210 140.273 96.662  1.00 50.00  ? 499 ILE A CG2   1 
ATOM 1794 C CD1   . ILE A 1 505 ? 143.312 137.252 97.317  1.00 51.69  ? 499 ILE A CD1   1 
ATOM 1795 N N     . ARG A 1 506 ? 143.671 143.041 96.512  1.00 53.38  ? 500 ARG A N     1 
ATOM 1796 C CA    . ARG A 1 506 ? 143.530 144.410 96.987  1.00 54.71  ? 500 ARG A CA    1 
ATOM 1797 C C     . ARG A 1 506 ? 142.067 144.740 97.242  1.00 51.11  ? 500 ARG A C     1 
ATOM 1798 O O     . ARG A 1 506 ? 141.177 144.317 96.500  1.00 52.39  ? 500 ARG A O     1 
ATOM 1799 C CB    . ARG A 1 506 ? 144.125 145.388 95.975  1.00 56.08  ? 500 ARG A CB    1 
ATOM 1800 C CG    . ARG A 1 506 ? 145.352 144.859 95.253  1.00 54.82  ? 500 ARG A CG    1 
ATOM 1801 C CD    . ARG A 1 506 ? 146.620 145.507 95.778  1.00 53.20  ? 500 ARG A CD    1 
ATOM 1802 N NE    . ARG A 1 506 ? 146.500 146.960 95.854  1.00 52.74  ? 500 ARG A NE    1 
ATOM 1803 C CZ    . ARG A 1 506 ? 146.639 147.779 94.822  1.00 51.88  ? 500 ARG A CZ    1 
ATOM 1804 N NH1   . ARG A 1 506 ? 146.906 147.323 93.608  1.00 53.83  ? 500 ARG A NH1   1 
ATOM 1805 N NH2   . ARG A 1 506 ? 146.506 149.089 95.011  1.00 50.60  ? 500 ARG A NH2   1 
ATOM 1806 N N     . SER A 1 507 ? 141.822 145.503 98.302  1.00 42.77  ? 501 SER A N     1 
ATOM 1807 C CA    . SER A 1 507 ? 140.484 145.918 98.675  1.00 43.49  ? 501 SER A CA    1 
ATOM 1808 C C     . SER A 1 507 ? 140.501 147.409 98.980  1.00 45.89  ? 501 SER A C     1 
ATOM 1809 O O     . SER A 1 507 ? 141.410 147.890 99.683  1.00 52.09  ? 501 SER A O     1 
ATOM 1810 C CB    . SER A 1 507 ? 139.980 145.138 99.893  1.00 50.29  ? 501 SER A CB    1 
ATOM 1811 O OG    . SER A 1 507 ? 139.075 145.918 100.655 1.00 46.15  ? 501 SER A OG    1 
ATOM 1812 N N     . PRO A 1 508 ? 139.537 148.171 98.472  1.00 43.93  ? 502 PRO A N     1 
ATOM 1813 C CA    . PRO A 1 508 ? 139.426 149.575 98.868  1.00 51.74  ? 502 PRO A CA    1 
ATOM 1814 C C     . PRO A 1 508 ? 139.069 149.694 100.338 1.00 54.17  ? 502 PRO A C     1 
ATOM 1815 O O     . PRO A 1 508 ? 138.454 148.803 100.927 1.00 59.61  ? 502 PRO A O     1 
ATOM 1816 C CB    . PRO A 1 508 ? 138.298 150.111 97.977  1.00 51.09  ? 502 PRO A CB    1 
ATOM 1817 C CG    . PRO A 1 508 ? 138.174 149.119 96.862  1.00 50.96  ? 502 PRO A CG    1 
ATOM 1818 C CD    . PRO A 1 508 ? 138.536 147.800 97.459  1.00 45.56  ? 502 PRO A CD    1 
ATOM 1819 N N     . VAL A 1 509 ? 139.481 150.805 100.935 1.00 46.62  ? 503 VAL A N     1 
ATOM 1820 C CA    . VAL A 1 509 ? 139.140 151.137 102.310 1.00 44.07  ? 503 VAL A CA    1 
ATOM 1821 C C     . VAL A 1 509 ? 138.470 152.501 102.306 1.00 46.74  ? 503 VAL A C     1 
ATOM 1822 O O     . VAL A 1 509 ? 138.909 153.413 101.596 1.00 55.11  ? 503 VAL A O     1 
ATOM 1823 C CB    . VAL A 1 509 ? 140.375 151.130 103.231 1.00 39.95  ? 503 VAL A CB    1 
ATOM 1824 C CG1   . VAL A 1 509 ? 139.978 151.464 104.656 1.00 41.98  ? 503 VAL A CG1   1 
ATOM 1825 C CG2   . VAL A 1 509 ? 141.055 149.780 103.182 1.00 40.27  ? 503 VAL A CG2   1 
ATOM 1826 N N     . ALA A 1 510 ? 137.393 152.630 103.078 1.00 38.41  ? 504 ALA A N     1 
ATOM 1827 C CA    . ALA A 1 510 ? 136.618 153.863 103.102 1.00 43.42  ? 504 ALA A CA    1 
ATOM 1828 C C     . ALA A 1 510 ? 137.479 155.052 103.507 1.00 45.27  ? 504 ALA A C     1 
ATOM 1829 O O     . ALA A 1 510 ? 137.971 155.117 104.638 1.00 52.38  ? 504 ALA A O     1 
ATOM 1830 C CB    . ALA A 1 510 ? 135.427 153.724 104.049 1.00 47.55  ? 504 ALA A CB    1 
ATOM 1831 N N     . LYS A 1 511 ? 137.675 155.986 102.573 1.00 36.89  ? 505 LYS A N     1 
ATOM 1832 C CA    . LYS A 1 511 ? 138.395 157.237 102.820 1.00 46.00  ? 505 LYS A CA    1 
ATOM 1833 C C     . LYS A 1 511 ? 139.861 157.003 103.174 1.00 48.46  ? 505 LYS A C     1 
ATOM 1834 O O     . LYS A 1 511 ? 140.492 157.843 103.821 1.00 53.07  ? 505 LYS A O     1 
ATOM 1835 C CB    . LYS A 1 511 ? 137.706 158.065 103.909 1.00 47.99  ? 505 LYS A CB    1 
ATOM 1836 C CG    . LYS A 1 511 ? 136.227 158.295 103.663 1.00 45.31  ? 505 LYS A CG    1 
ATOM 1837 C CD    . LYS A 1 511 ? 135.679 159.377 104.573 1.00 45.27  ? 505 LYS A CD    1 
ATOM 1838 C CE    . LYS A 1 511 ? 134.200 159.169 104.837 1.00 44.04  ? 505 LYS A CE    1 
ATOM 1839 N NZ    . LYS A 1 511 ? 133.457 158.868 103.584 1.00 44.21  ? 505 LYS A NZ    1 
ATOM 1840 N N     . MET A 1 512 ? 140.423 155.873 102.752 1.00 46.92  ? 506 MET A N     1 
ATOM 1841 C CA    . MET A 1 512 ? 141.838 155.584 102.959 1.00 41.45  ? 506 MET A CA    1 
ATOM 1842 C C     . MET A 1 512 ? 142.376 154.887 101.714 1.00 45.12  ? 506 MET A C     1 
ATOM 1843 O O     . MET A 1 512 ? 141.710 154.818 100.677 1.00 53.72  ? 506 MET A O     1 
ATOM 1844 C CB    . MET A 1 512 ? 142.065 154.730 104.216 1.00 48.70  ? 506 MET A CB    1 
ATOM 1845 C CG    . MET A 1 512 ? 141.556 155.336 105.508 1.00 50.71  ? 506 MET A CG    1 
ATOM 1846 S SD    . MET A 1 512 ? 141.241 154.092 106.768 1.00 54.43  ? 506 MET A SD    1 
ATOM 1847 C CE    . MET A 1 512 ? 141.715 154.996 108.234 1.00 49.55  ? 506 MET A CE    1 
ATOM 1848 N N     . GLU A 1 513 ? 143.594 154.369 101.826 1.00 54.52  ? 507 GLU A N     1 
ATOM 1849 C CA    . GLU A 1 513 ? 144.250 153.667 100.735 1.00 57.69  ? 507 GLU A CA    1 
ATOM 1850 C C     . GLU A 1 513 ? 143.833 152.200 100.711 1.00 60.79  ? 507 GLU A C     1 
ATOM 1851 O O     . GLU A 1 513 ? 143.319 151.656 101.690 1.00 66.68  ? 507 GLU A O     1 
ATOM 1852 C CB    . GLU A 1 513 ? 145.770 153.773 100.862 1.00 58.64  ? 507 GLU A CB    1 
ATOM 1853 C CG    . GLU A 1 513 ? 146.271 155.159 101.224 1.00 63.05  ? 507 GLU A CG    1 
ATOM 1854 C CD    . GLU A 1 513 ? 145.770 156.226 100.273 1.00 64.11  ? 507 GLU A CD    1 
ATOM 1855 O OE1   . GLU A 1 513 ? 145.915 156.045 99.045  1.00 63.27  ? 507 GLU A OE1   1 
ATOM 1856 O OE2   . GLU A 1 513 ? 145.233 157.246 100.752 1.00 62.68  ? 507 GLU A OE2   1 
ATOM 1857 N N     . ASP A 1 514 ? 144.062 151.564 99.566  1.00 60.16  ? 508 ASP A N     1 
ATOM 1858 C CA    . ASP A 1 514 ? 143.741 150.153 99.414  1.00 58.93  ? 508 ASP A CA    1 
ATOM 1859 C C     . ASP A 1 514 ? 144.655 149.299 100.286 1.00 55.74  ? 508 ASP A C     1 
ATOM 1860 O O     . ASP A 1 514 ? 145.799 149.663 100.568 1.00 56.80  ? 508 ASP A O     1 
ATOM 1861 C CB    . ASP A 1 514 ? 143.871 149.736 97.950  1.00 60.85  ? 508 ASP A CB    1 
ATOM 1862 C CG    . ASP A 1 514 ? 142.827 150.386 97.065  1.00 63.48  ? 508 ASP A CG    1 
ATOM 1863 O OD1   . ASP A 1 514 ? 142.215 151.384 97.501  1.00 60.19  ? 508 ASP A OD1   1 
ATOM 1864 O OD2   . ASP A 1 514 ? 142.616 149.900 95.934  1.00 62.96  ? 508 ASP A OD2   1 
ATOM 1865 N N     . VAL A 1 515 ? 144.137 148.150 100.718 1.00 50.25  ? 509 VAL A N     1 
ATOM 1866 C CA    . VAL A 1 515 ? 144.884 147.223 101.562 1.00 56.43  ? 509 VAL A CA    1 
ATOM 1867 C C     . VAL A 1 515 ? 144.893 145.847 100.910 1.00 55.65  ? 509 VAL A C     1 
ATOM 1868 O O     . VAL A 1 515 ? 143.912 145.441 100.279 1.00 55.19  ? 509 VAL A O     1 
ATOM 1869 C CB    . VAL A 1 515 ? 144.309 147.146 102.991 1.00 47.13  ? 509 VAL A CB    1 
ATOM 1870 C CG1   . VAL A 1 515 ? 144.396 148.499 103.666 1.00 47.86  ? 509 VAL A CG1   1 
ATOM 1871 C CG2   . VAL A 1 515 ? 142.876 146.648 102.970 1.00 47.86  ? 509 VAL A CG2   1 
ATOM 1872 N N     . SER A 1 516 ? 146.004 145.135 101.061 1.00 47.35  ? 510 SER A N     1 
ATOM 1873 C CA    . SER A 1 516 ? 146.180 143.812 100.475 1.00 45.28  ? 510 SER A CA    1 
ATOM 1874 C C     . SER A 1 516 ? 146.025 142.747 101.550 1.00 56.44  ? 510 SER A C     1 
ATOM 1875 O O     . SER A 1 516 ? 146.634 142.846 102.620 1.00 60.82  ? 510 SER A O     1 
ATOM 1876 C CB    . SER A 1 516 ? 147.552 143.688 99.816  1.00 48.78  ? 510 SER A CB    1 
ATOM 1877 O OG    . SER A 1 516 ? 148.563 143.587 100.801 1.00 53.83  ? 510 SER A OG    1 
ATOM 1878 N N     . PHE A 1 517 ? 145.216 141.727 101.260 1.00 53.01  ? 511 PHE A N     1 
ATOM 1879 C CA    . PHE A 1 517 ? 144.986 140.617 102.182 1.00 32.23  ? 511 PHE A CA    1 
ATOM 1880 C C     . PHE A 1 517 ? 146.169 139.663 102.091 1.00 41.07  ? 511 PHE A C     1 
ATOM 1881 O O     . PHE A 1 517 ? 146.245 138.807 101.208 1.00 45.39  ? 511 PHE A O     1 
ATOM 1882 C CB    . PHE A 1 517 ? 143.671 139.915 101.867 1.00 24.54  ? 511 PHE A CB    1 
ATOM 1883 C CG    . PHE A 1 517 ? 142.456 140.734 102.190 1.00 25.84  ? 511 PHE A CG    1 
ATOM 1884 C CD1   . PHE A 1 517 ? 141.971 140.790 103.481 1.00 39.25  ? 511 PHE A CD1   1 
ATOM 1885 C CD2   . PHE A 1 517 ? 141.798 141.449 101.207 1.00 35.01  ? 511 PHE A CD2   1 
ATOM 1886 C CE1   . PHE A 1 517 ? 140.856 141.543 103.786 1.00 41.77  ? 511 PHE A CE1   1 
ATOM 1887 C CE2   . PHE A 1 517 ? 140.682 142.203 101.509 1.00 39.06  ? 511 PHE A CE2   1 
ATOM 1888 C CZ    . PHE A 1 517 ? 140.214 142.251 102.798 1.00 38.19  ? 511 PHE A CZ    1 
ATOM 1889 N N     . ASP A 1 518 ? 147.112 139.813 103.023 1.00 47.12  ? 512 ASP A N     1 
ATOM 1890 C CA    . ASP A 1 518 ? 148.326 139.004 102.992 1.00 48.48  ? 512 ASP A CA    1 
ATOM 1891 C C     . ASP A 1 518 ? 148.017 137.573 103.416 1.00 53.14  ? 512 ASP A C     1 
ATOM 1892 O O     . ASP A 1 518 ? 148.209 136.627 102.643 1.00 53.53  ? 512 ASP A O     1 
ATOM 1893 C CB    . ASP A 1 518 ? 149.390 139.668 103.887 1.00 51.51  ? 512 ASP A CB    1 
ATOM 1894 C CG    . ASP A 1 518 ? 150.496 138.719 104.371 1.00 55.21  ? 512 ASP A CG    1 
ATOM 1895 O OD1   . ASP A 1 518 ? 150.553 137.527 104.013 1.00 58.35  ? 512 ASP A OD1   1 
ATOM 1896 O OD2   . ASP A 1 518 ? 151.339 139.203 105.155 1.00 53.17  ? 512 ASP A OD2   1 
ATOM 1897 N N     . SER A 1 519 ? 147.537 137.394 104.642 1.00 44.76  ? 513 SER A N     1 
ATOM 1898 C CA    . SER A 1 519 ? 147.312 136.067 105.203 1.00 41.63  ? 513 SER A CA    1 
ATOM 1899 C C     . SER A 1 519 ? 145.867 135.659 104.949 1.00 44.67  ? 513 SER A C     1 
ATOM 1900 O O     . SER A 1 519 ? 144.938 136.242 105.518 1.00 50.67  ? 513 SER A O     1 
ATOM 1901 C CB    . SER A 1 519 ? 147.634 136.057 106.694 1.00 44.60  ? 513 SER A CB    1 
ATOM 1902 O OG    . SER A 1 519 ? 149.034 136.083 106.919 1.00 50.43  ? 513 SER A OG    1 
ATOM 1903 N N     . THR A 1 520 ? 145.681 134.661 104.088 1.00 40.48  ? 514 THR A N     1 
ATOM 1904 C CA    . THR A 1 520 ? 144.369 134.106 103.775 1.00 35.87  ? 514 THR A CA    1 
ATOM 1905 C C     . THR A 1 520 ? 144.440 132.603 103.990 1.00 41.54  ? 514 THR A C     1 
ATOM 1906 O O     . THR A 1 520 ? 145.311 131.938 103.420 1.00 53.87  ? 514 THR A O     1 
ATOM 1907 C CB    . THR A 1 520 ? 143.966 134.427 102.335 1.00 39.27  ? 514 THR A CB    1 
ATOM 1908 O OG1   . THR A 1 520 ? 144.292 135.789 102.040 1.00 42.94  ? 514 THR A OG1   1 
ATOM 1909 C CG2   . THR A 1 520 ? 142.485 134.240 102.155 1.00 43.91  ? 514 THR A CG2   1 
ATOM 1910 N N     . GLY A 1 521 ? 143.531 132.066 104.803 1.00 36.50  ? 515 GLY A N     1 
ATOM 1911 C CA    . GLY A 1 521 ? 143.639 130.670 105.177 1.00 38.46  ? 515 GLY A CA    1 
ATOM 1912 C C     . GLY A 1 521 ? 142.300 130.012 105.427 1.00 33.04  ? 515 GLY A C     1 
ATOM 1913 O O     . GLY A 1 521 ? 141.257 130.666 105.499 1.00 41.12  ? 515 GLY A O     1 
ATOM 1914 N N     . LEU A 1 522 ? 142.355 128.689 105.571 1.00 26.94  ? 516 LEU A N     1 
ATOM 1915 C CA    . LEU A 1 522 ? 141.181 127.857 105.814 1.00 27.41  ? 516 LEU A CA    1 
ATOM 1916 C C     . LEU A 1 522 ? 141.474 126.945 106.997 1.00 33.56  ? 516 LEU A C     1 
ATOM 1917 O O     . LEU A 1 522 ? 142.254 125.994 106.871 1.00 45.39  ? 516 LEU A O     1 
ATOM 1918 C CB    . LEU A 1 522 ? 140.827 127.026 104.580 1.00 32.92  ? 516 LEU A CB    1 
ATOM 1919 C CG    . LEU A 1 522 ? 140.302 127.739 103.338 1.00 40.68  ? 516 LEU A CG    1 
ATOM 1920 C CD1   . LEU A 1 522 ? 141.259 127.524 102.180 1.00 41.80  ? 516 LEU A CD1   1 
ATOM 1921 C CD2   . LEU A 1 522 ? 138.917 127.229 102.991 1.00 37.19  ? 516 LEU A CD2   1 
ATOM 1922 N N     . ARG A 1 523 ? 140.854 127.226 108.138 1.00 29.58  ? 517 ARG A N     1 
ATOM 1923 C CA    . ARG A 1 523 ? 140.965 126.368 109.304 1.00 29.13  ? 517 ARG A CA    1 
ATOM 1924 C C     . ARG A 1 523 ? 139.807 125.378 109.326 1.00 34.21  ? 517 ARG A C     1 
ATOM 1925 O O     . ARG A 1 523 ? 138.872 125.455 108.526 1.00 43.87  ? 517 ARG A O     1 
ATOM 1926 C CB    . ARG A 1 523 ? 141.007 127.199 110.586 1.00 29.52  ? 517 ARG A CB    1 
ATOM 1927 C CG    . ARG A 1 523 ? 142.180 128.152 110.669 1.00 35.56  ? 517 ARG A CG    1 
ATOM 1928 C CD    . ARG A 1 523 ? 143.490 127.397 110.784 1.00 36.05  ? 517 ARG A CD    1 
ATOM 1929 N NE    . ARG A 1 523 ? 144.637 128.279 110.632 1.00 33.76  ? 517 ARG A NE    1 
ATOM 1930 C CZ    . ARG A 1 523 ? 145.223 128.551 109.474 1.00 42.65  ? 517 ARG A CZ    1 
ATOM 1931 N NH1   . ARG A 1 523 ? 144.791 128.018 108.343 1.00 38.83  ? 517 ARG A NH1   1 
ATOM 1932 N NH2   . ARG A 1 523 ? 146.266 129.375 109.450 1.00 41.25  ? 517 ARG A NH2   1 
ATOM 1933 N N     . GLY A 1 524 ? 139.866 124.435 110.263 1.00 33.70  ? 518 GLY A N     1 
ATOM 1934 C CA    . GLY A 1 524 ? 138.890 123.361 110.254 1.00 25.86  ? 518 GLY A CA    1 
ATOM 1935 C C     . GLY A 1 524 ? 139.178 122.400 109.120 1.00 32.86  ? 518 GLY A C     1 
ATOM 1936 O O     . GLY A 1 524 ? 140.332 122.072 108.826 1.00 45.75  ? 518 GLY A O     1 
ATOM 1937 N N     . GLY A 1 525 ? 138.118 121.937 108.467 1.00 29.18  ? 519 GLY A N     1 
ATOM 1938 C CA    . GLY A 1 525 ? 138.259 121.062 107.324 1.00 41.44  ? 519 GLY A CA    1 
ATOM 1939 C C     . GLY A 1 525 ? 138.220 119.592 107.695 1.00 46.55  ? 519 GLY A C     1 
ATOM 1940 O O     . GLY A 1 525 ? 138.121 119.204 108.861 1.00 56.18  ? 519 GLY A O     1 
ATOM 1941 N N     . ILE A 1 526 ? 138.299 118.757 106.662 1.00 52.79  ? 520 ILE A N     1 
ATOM 1942 C CA    . ILE A 1 526 ? 138.245 117.314 106.855 1.00 53.14  ? 520 ILE A CA    1 
ATOM 1943 C C     . ILE A 1 526 ? 139.590 116.820 107.364 1.00 51.45  ? 520 ILE A C     1 
ATOM 1944 O O     . ILE A 1 526 ? 140.642 117.125 106.788 1.00 54.15  ? 520 ILE A O     1 
ATOM 1945 C CB    . ILE A 1 526 ? 137.845 116.615 105.547 1.00 53.00  ? 520 ILE A CB    1 
ATOM 1946 C CG1   . ILE A 1 526 ? 136.325 116.625 105.384 1.00 51.87  ? 520 ILE A CG1   1 
ATOM 1947 C CG2   . ILE A 1 526 ? 138.365 115.192 105.515 1.00 53.53  ? 520 ILE A CG2   1 
ATOM 1948 C CD1   . ILE A 1 526 ? 135.853 116.055 104.070 1.00 48.60  ? 520 ILE A CD1   1 
ATOM 1949 N N     . GLY A 1 527 ? 139.564 116.057 108.456 1.00 40.67  ? 521 GLY A N     1 
ATOM 1950 C CA    . GLY A 1 527 ? 140.777 115.480 109.000 1.00 46.67  ? 521 GLY A CA    1 
ATOM 1951 C C     . GLY A 1 527 ? 141.257 114.295 108.191 1.00 49.91  ? 521 GLY A C     1 
ATOM 1952 O O     . GLY A 1 527 ? 142.356 114.316 107.629 1.00 52.31  ? 521 GLY A O     1 
ATOM 1953 N N     . SER A 1 528 ? 140.438 113.250 108.129 1.00 50.92  ? 522 SER A N     1 
ATOM 1954 C CA    . SER A 1 528 ? 140.683 112.098 107.275 1.00 51.53  ? 522 SER A CA    1 
ATOM 1955 C C     . SER A 1 528 ? 139.464 111.873 106.392 1.00 51.79  ? 522 SER A C     1 
ATOM 1956 O O     . SER A 1 528 ? 138.324 111.958 106.857 1.00 52.00  ? 522 SER A O     1 
ATOM 1957 C CB    . SER A 1 528 ? 140.983 110.844 108.101 1.00 53.24  ? 522 SER A CB    1 
ATOM 1958 O OG    . SER A 1 528 ? 139.794 110.273 108.609 1.00 51.97  ? 522 SER A OG    1 
ATOM 1959 N N     . GLN A 1 529 ? 139.712 111.592 105.112 1.00 49.17  ? 523 GLN A N     1 
ATOM 1960 C CA    . GLN A 1 529 ? 138.614 111.476 104.157 1.00 50.10  ? 523 GLN A CA    1 
ATOM 1961 C C     . GLN A 1 529 ? 137.795 110.213 104.393 1.00 55.57  ? 523 GLN A C     1 
ATOM 1962 O O     . GLN A 1 529 ? 136.567 110.229 104.244 1.00 61.01  ? 523 GLN A O     1 
ATOM 1963 C CB    . GLN A 1 529 ? 139.160 111.505 102.731 1.00 56.14  ? 523 GLN A CB    1 
ATOM 1964 C CG    . GLN A 1 529 ? 139.492 112.899 102.233 1.00 57.90  ? 523 GLN A CG    1 
ATOM 1965 C CD    . GLN A 1 529 ? 138.274 113.630 101.708 1.00 62.07  ? 523 GLN A CD    1 
ATOM 1966 O OE1   . GLN A 1 529 ? 137.260 113.014 101.386 1.00 60.94  ? 523 GLN A OE1   1 
ATOM 1967 N NE2   . GLN A 1 529 ? 138.370 114.950 101.620 1.00 61.25  ? 523 GLN A NE2   1 
ATOM 1968 N N     . LYS A 1 530 ? 138.453 109.110 104.755 1.00 48.11  ? 524 LYS A N     1 
ATOM 1969 C CA    . LYS A 1 530 ? 137.741 107.851 104.944 1.00 45.12  ? 524 LYS A CA    1 
ATOM 1970 C C     . LYS A 1 530 ? 136.729 107.949 106.078 1.00 43.73  ? 524 LYS A C     1 
ATOM 1971 O O     . LYS A 1 530 ? 135.586 107.493 105.942 1.00 47.97  ? 524 LYS A O     1 
ATOM 1972 C CB    . LYS A 1 530 ? 138.736 106.722 105.211 1.00 49.94  ? 524 LYS A CB    1 
ATOM 1973 C CG    . LYS A 1 530 ? 138.330 105.382 104.629 1.00 54.36  ? 524 LYS A CG    1 
ATOM 1974 C CD    . LYS A 1 530 ? 139.496 104.408 104.625 1.00 57.28  ? 524 LYS A CD    1 
ATOM 1975 C CE    . LYS A 1 530 ? 139.726 103.816 106.005 1.00 53.81  ? 524 LYS A CE    1 
ATOM 1976 N NZ    . LYS A 1 530 ? 138.862 102.629 106.252 1.00 52.97  ? 524 LYS A NZ    1 
ATOM 1977 N N     . LEU A 1 531 ? 137.128 108.543 107.204 1.00 44.94  ? 525 LEU A N     1 
ATOM 1978 C CA    . LEU A 1 531 ? 136.215 108.676 108.332 1.00 46.95  ? 525 LEU A CA    1 
ATOM 1979 C C     . LEU A 1 531 ? 135.030 109.567 107.982 1.00 45.38  ? 525 LEU A C     1 
ATOM 1980 O O     . LEU A 1 531 ? 133.885 109.249 108.320 1.00 48.55  ? 525 LEU A O     1 
ATOM 1981 C CB    . LEU A 1 531 ? 136.961 109.228 109.545 1.00 41.74  ? 525 LEU A CB    1 
ATOM 1982 C CG    . LEU A 1 531 ? 136.424 108.840 110.920 1.00 33.31  ? 525 LEU A CG    1 
ATOM 1983 C CD1   . LEU A 1 531 ? 136.214 107.340 111.007 1.00 41.91  ? 525 LEU A CD1   1 
ATOM 1984 C CD2   . LEU A 1 531 ? 137.374 109.315 112.001 1.00 39.15  ? 525 LEU A CD2   1 
ATOM 1985 N N     . HIS A 1 532 ? 135.288 110.689 107.306 1.00 42.79  ? 526 HIS A N     1 
ATOM 1986 C CA    . HIS A 1 532 ? 134.208 111.581 106.899 1.00 44.00  ? 526 HIS A CA    1 
ATOM 1987 C C     . HIS A 1 532 ? 133.228 110.865 105.979 1.00 52.31  ? 526 HIS A C     1 
ATOM 1988 O O     . HIS A 1 532 ? 132.005 110.979 106.142 1.00 51.80  ? 526 HIS A O     1 
ATOM 1989 C CB    . HIS A 1 532 ? 134.799 112.812 106.210 1.00 43.90  ? 526 HIS A CB    1 
ATOM 1990 C CG    . HIS A 1 532 ? 133.844 113.955 106.076 1.00 46.20  ? 526 HIS A CG    1 
ATOM 1991 N ND1   . HIS A 1 532 ? 133.106 114.179 104.934 1.00 53.86  ? 526 HIS A ND1   1 
ATOM 1992 C CD2   . HIS A 1 532 ? 133.525 114.955 106.931 1.00 50.02  ? 526 HIS A CD2   1 
ATOM 1993 C CE1   . HIS A 1 532 ? 132.363 115.259 105.096 1.00 49.80  ? 526 HIS A CE1   1 
ATOM 1994 N NE2   . HIS A 1 532 ? 132.601 115.751 106.298 1.00 50.68  ? 526 HIS A NE2   1 
ATOM 1995 N N     . ARG A 1 533 ? 133.755 110.104 105.017 1.00 49.87  ? 527 ARG A N     1 
ATOM 1996 C CA    . ARG A 1 533 ? 132.896 109.359 104.107 1.00 48.42  ? 527 ARG A CA    1 
ATOM 1997 C C     . ARG A 1 533 ? 132.066 108.325 104.856 1.00 52.77  ? 527 ARG A C     1 
ATOM 1998 O O     . ARG A 1 533 ? 130.880 108.137 104.559 1.00 54.08  ? 527 ARG A O     1 
ATOM 1999 C CB    . ARG A 1 533 ? 133.746 108.694 103.026 1.00 44.44  ? 527 ARG A CB    1 
ATOM 2000 C CG    . ARG A 1 533 ? 132.971 107.831 102.053 1.00 45.31  ? 527 ARG A CG    1 
ATOM 2001 C CD    . ARG A 1 533 ? 133.861 107.353 100.916 1.00 49.55  ? 527 ARG A CD    1 
ATOM 2002 N NE    . ARG A 1 533 ? 135.176 106.928 101.382 1.00 55.95  ? 527 ARG A NE    1 
ATOM 2003 C CZ    . ARG A 1 533 ? 136.308 107.570 101.126 1.00 56.00  ? 527 ARG A CZ    1 
ATOM 2004 N NH1   . ARG A 1 533 ? 136.324 108.685 100.415 1.00 54.51  ? 527 ARG A NH1   1 
ATOM 2005 N NH2   . ARG A 1 533 ? 137.451 107.082 101.597 1.00 50.50  ? 527 ARG A NH2   1 
ATOM 2006 N N     . GLU A 1 534 ? 132.670 107.643 105.832 1.00 44.76  ? 528 GLU A N     1 
ATOM 2007 C CA    . GLU A 1 534 ? 131.931 106.635 106.588 1.00 31.80  ? 528 GLU A CA    1 
ATOM 2008 C C     . GLU A 1 534 ? 130.822 107.259 107.425 1.00 41.64  ? 528 GLU A C     1 
ATOM 2009 O O     . GLU A 1 534 ? 129.711 106.718 107.486 1.00 50.78  ? 528 GLU A O     1 
ATOM 2010 C CB    . GLU A 1 534 ? 132.885 105.832 107.468 1.00 38.95  ? 528 GLU A CB    1 
ATOM 2011 C CG    . GLU A 1 534 ? 133.741 104.841 106.697 1.00 49.32  ? 528 GLU A CG    1 
ATOM 2012 C CD    . GLU A 1 534 ? 135.038 104.517 107.407 1.00 59.68  ? 528 GLU A CD    1 
ATOM 2013 O OE1   . GLU A 1 534 ? 134.983 104.003 108.542 1.00 61.03  ? 528 GLU A OE1   1 
ATOM 2014 O OE2   . GLU A 1 534 ? 136.112 104.775 106.831 1.00 56.85  ? 528 GLU A OE2   1 
ATOM 2015 N N     . MET A 1 535 ? 131.093 108.394 108.081 1.00 37.88  ? 529 MET A N     1 
ATOM 2016 C CA    . MET A 1 535 ? 130.026 109.060 108.826 1.00 36.76  ? 529 MET A CA    1 
ATOM 2017 C C     . MET A 1 535 ? 128.905 109.510 107.901 1.00 39.06  ? 529 MET A C     1 
ATOM 2018 O O     . MET A 1 535 ? 127.726 109.381 108.243 1.00 38.12  ? 529 MET A O     1 
ATOM 2019 C CB    . MET A 1 535 ? 130.545 110.257 109.630 1.00 34.45  ? 529 MET A CB    1 
ATOM 2020 C CG    . MET A 1 535 ? 131.886 110.095 110.303 1.00 31.48  ? 529 MET A CG    1 
ATOM 2021 S SD    . MET A 1 535 ? 132.021 111.188 111.728 1.00 39.69  ? 529 MET A SD    1 
ATOM 2022 C CE    . MET A 1 535 ? 133.636 110.745 112.353 1.00 32.73  ? 529 MET A CE    1 
ATOM 2023 N N     . HIS A 1 536 ? 129.247 110.040 106.723 1.00 43.73  ? 530 HIS A N     1 
ATOM 2024 C CA    . HIS A 1 536 ? 128.206 110.462 105.790 1.00 42.55  ? 530 HIS A CA    1 
ATOM 2025 C C     . HIS A 1 536 ? 127.358 109.278 105.338 1.00 45.39  ? 530 HIS A C     1 
ATOM 2026 O O     . HIS A 1 536 ? 126.120 109.354 105.306 1.00 51.26  ? 530 HIS A O     1 
ATOM 2027 C CB    . HIS A 1 536 ? 128.834 111.171 104.591 1.00 44.20  ? 530 HIS A CB    1 
ATOM 2028 C CG    . HIS A 1 536 ? 127.962 112.230 103.996 1.00 48.63  ? 530 HIS A CG    1 
ATOM 2029 N ND1   . HIS A 1 536 ? 128.420 113.130 103.057 1.00 49.58  ? 530 HIS A ND1   1 
ATOM 2030 C CD2   . HIS A 1 536 ? 126.660 112.535 104.206 1.00 48.76  ? 530 HIS A CD2   1 
ATOM 2031 C CE1   . HIS A 1 536 ? 127.437 113.942 102.713 1.00 53.56  ? 530 HIS A CE1   1 
ATOM 2032 N NE2   . HIS A 1 536 ? 126.358 113.602 103.397 1.00 55.32  ? 530 HIS A NE2   1 
ATOM 2033 N N     . ASN A 1 537 ? 128.009 108.163 104.993 1.00 41.32  ? 531 ASN A N     1 
ATOM 2034 C CA    . ASN A 1 537 ? 127.277 106.986 104.536 1.00 39.99  ? 531 ASN A CA    1 
ATOM 2035 C C     . ASN A 1 537 ? 126.368 106.440 105.626 1.00 43.47  ? 531 ASN A C     1 
ATOM 2036 O O     . ASN A 1 537 ? 125.205 106.103 105.365 1.00 51.11  ? 531 ASN A O     1 
ATOM 2037 C CB    . ASN A 1 537 ? 128.252 105.909 104.067 1.00 40.78  ? 531 ASN A CB    1 
ATOM 2038 C CG    . ASN A 1 537 ? 129.025 106.317 102.833 1.00 46.89  ? 531 ASN A CG    1 
ATOM 2039 O OD1   . ASN A 1 537 ? 128.805 107.393 102.277 1.00 48.55  ? 531 ASN A OD1   1 
ATOM 2040 N ND2   . ASN A 1 537 ? 129.935 105.458 102.394 1.00 43.70  ? 531 ASN A ND2   1 
ATOM 2041 N N     . LEU A 1 538 ? 126.871 106.347 106.860 1.00 34.26  ? 532 LEU A N     1 
ATOM 2042 C CA    . LEU A 1 538 ? 126.042 105.812 107.930 1.00 31.00  ? 532 LEU A CA    1 
ATOM 2043 C C     . LEU A 1 538 ? 124.917 106.767 108.305 1.00 29.55  ? 532 LEU A C     1 
ATOM 2044 O O     . LEU A 1 538 ? 123.826 106.320 108.672 1.00 32.95  ? 532 LEU A O     1 
ATOM 2045 C CB    . LEU A 1 538 ? 126.892 105.480 109.153 1.00 30.14  ? 532 LEU A CB    1 
ATOM 2046 C CG    . LEU A 1 538 ? 126.255 104.424 110.055 1.00 25.77  ? 532 LEU A CG    1 
ATOM 2047 C CD1   . LEU A 1 538 ? 126.159 103.092 109.333 1.00 31.81  ? 532 LEU A CD1   1 
ATOM 2048 C CD2   . LEU A 1 538 ? 127.033 104.281 111.341 1.00 32.64  ? 532 LEU A CD2   1 
ATOM 2049 N N     . SER A 1 539 ? 125.153 108.079 108.215 1.00 32.12  ? 533 SER A N     1 
ATOM 2050 C CA    . SER A 1 539 ? 124.073 109.030 108.445 1.00 32.81  ? 533 SER A CA    1 
ATOM 2051 C C     . SER A 1 539 ? 122.977 108.863 107.405 1.00 36.65  ? 533 SER A C     1 
ATOM 2052 O O     . SER A 1 539 ? 121.789 108.891 107.740 1.00 48.39  ? 533 SER A O     1 
ATOM 2053 C CB    . SER A 1 539 ? 124.615 110.459 108.433 1.00 39.14  ? 533 SER A CB    1 
ATOM 2054 O OG    . SER A 1 539 ? 123.565 111.399 108.576 1.00 37.97  ? 533 SER A OG    1 
ATOM 2055 N N     . ASP A 1 540 ? 123.353 108.674 106.137 1.00 38.91  ? 534 ASP A N     1 
ATOM 2056 C CA    . ASP A 1 540 ? 122.347 108.426 105.106 1.00 43.32  ? 534 ASP A CA    1 
ATOM 2057 C C     . ASP A 1 540 ? 121.589 107.128 105.367 1.00 46.42  ? 534 ASP A C     1 
ATOM 2058 O O     . ASP A 1 540 ? 120.360 107.070 105.212 1.00 46.92  ? 534 ASP A O     1 
ATOM 2059 C CB    . ASP A 1 540 ? 123.009 108.390 103.729 1.00 47.10  ? 534 ASP A CB    1 
ATOM 2060 C CG    . ASP A 1 540 ? 123.512 109.748 103.290 1.00 51.94  ? 534 ASP A CG    1 
ATOM 2061 O OD1   . ASP A 1 540 ? 123.050 110.763 103.849 1.00 47.35  ? 534 ASP A OD1   1 
ATOM 2062 O OD2   . ASP A 1 540 ? 124.369 109.801 102.382 1.00 55.23  ? 534 ASP A OD2   1 
ATOM 2063 N N     . ARG A 1 541 ? 122.308 106.072 105.757 1.00 43.23  ? 535 ARG A N     1 
ATOM 2064 C CA    . ARG A 1 541 ? 121.660 104.790 106.013 1.00 34.06  ? 535 ARG A CA    1 
ATOM 2065 C C     . ARG A 1 541 ? 120.667 104.891 107.163 1.00 30.79  ? 535 ARG A C     1 
ATOM 2066 O O     . ARG A 1 541 ? 119.544 104.387 107.066 1.00 40.43  ? 535 ARG A O     1 
ATOM 2067 C CB    . ARG A 1 541 ? 122.711 103.719 106.302 1.00 38.51  ? 535 ARG A CB    1 
ATOM 2068 C CG    . ARG A 1 541 ? 122.287 102.315 105.912 1.00 43.01  ? 535 ARG A CG    1 
ATOM 2069 C CD    . ARG A 1 541 ? 123.345 101.301 106.299 1.00 41.33  ? 535 ARG A CD    1 
ATOM 2070 N NE    . ARG A 1 541 ? 122.887 99.929  106.115 1.00 38.93  ? 535 ARG A NE    1 
ATOM 2071 C CZ    . ARG A 1 541 ? 123.671 98.863  106.183 1.00 45.75  ? 535 ARG A CZ    1 
ATOM 2072 N NH1   . ARG A 1 541 ? 124.965 98.974  106.436 1.00 51.82  ? 535 ARG A NH1   1 
ATOM 2073 N NH2   . ARG A 1 541 ? 123.145 97.657  105.995 1.00 45.53  ? 535 ARG A NH2   1 
ATOM 2074 N N     . CYS A 1 542 ? 121.057 105.548 108.257 1.00 34.58  ? 536 CYS A N     1 
ATOM 2075 C CA    . CYS A 1 542 ? 120.143 105.736 109.378 1.00 36.50  ? 536 CYS A CA    1 
ATOM 2076 C C     . CYS A 1 542 ? 119.017 106.703 109.042 1.00 45.01  ? 536 CYS A C     1 
ATOM 2077 O O     . CYS A 1 542 ? 117.947 106.628 109.653 1.00 46.77  ? 536 CYS A O     1 
ATOM 2078 C CB    . CYS A 1 542 ? 120.906 106.233 110.606 1.00 32.37  ? 536 CYS A CB    1 
ATOM 2079 S SG    . CYS A 1 542 ? 122.235 105.142 111.152 1.00 44.26  ? 536 CYS A SG    1 
ATOM 2080 N N     . PHE A 1 543 ? 119.242 107.616 108.096 1.00 48.03  ? 537 PHE A N     1 
ATOM 2081 C CA    . PHE A 1 543 ? 118.177 108.502 107.645 1.00 37.41  ? 537 PHE A CA    1 
ATOM 2082 C C     . PHE A 1 543 ? 117.100 107.728 106.904 1.00 43.61  ? 537 PHE A C     1 
ATOM 2083 O O     . PHE A 1 543 ? 115.903 107.951 107.120 1.00 51.69  ? 537 PHE A O     1 
ATOM 2084 C CB    . PHE A 1 543 ? 118.767 109.592 106.753 1.00 39.11  ? 537 PHE A CB    1 
ATOM 2085 C CG    . PHE A 1 543 ? 117.772 110.616 106.301 1.00 51.56  ? 537 PHE A CG    1 
ATOM 2086 C CD1   . PHE A 1 543 ? 117.519 110.802 104.954 1.00 49.99  ? 537 PHE A CD1   1 
ATOM 2087 C CD2   . PHE A 1 543 ? 117.112 111.412 107.219 1.00 50.23  ? 537 PHE A CD2   1 
ATOM 2088 C CE1   . PHE A 1 543 ? 116.611 111.746 104.532 1.00 47.50  ? 537 PHE A CE1   1 
ATOM 2089 C CE2   . PHE A 1 543 ? 116.207 112.361 106.801 1.00 43.49  ? 537 PHE A CE2   1 
ATOM 2090 C CZ    . PHE A 1 543 ? 115.955 112.528 105.456 1.00 48.06  ? 537 PHE A CZ    1 
ATOM 2091 N N     . TYR A 1 544 ? 117.504 106.810 106.025 1.00 52.36  ? 538 TYR A N     1 
ATOM 2092 C CA    . TYR A 1 544 ? 116.530 106.044 105.256 1.00 49.98  ? 538 TYR A CA    1 
ATOM 2093 C C     . TYR A 1 544 ? 115.969 104.848 106.020 1.00 47.97  ? 538 TYR A C     1 
ATOM 2094 O O     . TYR A 1 544 ? 114.903 104.337 105.651 1.00 46.61  ? 538 TYR A O     1 
ATOM 2095 C CB    . TYR A 1 544 ? 117.152 105.578 103.940 1.00 48.46  ? 538 TYR A CB    1 
ATOM 2096 C CG    . TYR A 1 544 ? 117.456 106.720 103.002 1.00 49.28  ? 538 TYR A CG    1 
ATOM 2097 C CD1   . TYR A 1 544 ? 116.489 107.669 102.706 1.00 49.99  ? 538 TYR A CD1   1 
ATOM 2098 C CD2   . TYR A 1 544 ? 118.709 106.863 102.430 1.00 52.18  ? 538 TYR A CD2   1 
ATOM 2099 C CE1   . TYR A 1 544 ? 116.757 108.719 101.857 1.00 50.34  ? 538 TYR A CE1   1 
ATOM 2100 C CE2   . TYR A 1 544 ? 118.989 107.911 101.578 1.00 53.98  ? 538 TYR A CE2   1 
ATOM 2101 C CZ    . TYR A 1 544 ? 118.009 108.835 101.296 1.00 52.75  ? 538 TYR A CZ    1 
ATOM 2102 O OH    . TYR A 1 544 ? 118.280 109.883 100.449 1.00 58.93  ? 538 TYR A OH    1 
ATOM 2103 N N     . GLY A 1 545 ? 116.646 104.408 107.082 1.00 53.96  ? 539 GLY A N     1 
ATOM 2104 C CA    . GLY A 1 545 ? 116.159 103.264 107.831 1.00 46.66  ? 539 GLY A CA    1 
ATOM 2105 C C     . GLY A 1 545 ? 114.829 103.517 108.509 1.00 47.03  ? 539 GLY A C     1 
ATOM 2106 O O     . GLY A 1 545 ? 113.957 102.645 108.521 1.00 54.04  ? 539 GLY A O     1 
ATOM 2107 N N     . ALA A 1 546 ? 114.655 104.707 109.091 1.00 41.25  ? 540 ALA A N     1 
ATOM 2108 C CA    . ALA A 1 546 ? 113.412 105.023 109.789 1.00 46.31  ? 540 ALA A CA    1 
ATOM 2109 C C     . ALA A 1 546 ? 112.225 105.006 108.835 1.00 60.03  ? 540 ALA A C     1 
ATOM 2110 O O     . ALA A 1 546 ? 111.166 104.441 109.142 1.00 65.31  ? 540 ALA A O     1 
ATOM 2111 C CB    . ALA A 1 546 ? 113.531 106.382 110.478 1.00 43.08  ? 540 ALA A CB    1 
ATOM 2112 N N     . ARG A 1 547 ? 112.387 105.617 107.663 1.00 62.04  ? 541 ARG A N     1 
ATOM 2113 C CA    . ARG A 1 547 ? 111.316 105.600 106.674 1.00 58.32  ? 541 ARG A CA    1 
ATOM 2114 C C     . ARG A 1 547 ? 111.070 104.193 106.146 1.00 54.83  ? 541 ARG A C     1 
ATOM 2115 O O     . ARG A 1 547 ? 109.916 103.815 105.898 1.00 53.75  ? 541 ARG A O     1 
ATOM 2116 C CB    . ARG A 1 547 ? 111.642 106.571 105.544 1.00 56.18  ? 541 ARG A CB    1 
ATOM 2117 C CG    . ARG A 1 547 ? 111.884 107.981 106.043 1.00 49.77  ? 541 ARG A CG    1 
ATOM 2118 C CD    . ARG A 1 547 ? 113.154 108.595 105.493 1.00 53.42  ? 541 ARG A CD    1 
ATOM 2119 N NE    . ARG A 1 547 ? 113.119 110.049 105.610 1.00 62.35  ? 541 ARG A NE    1 
ATOM 2120 C CZ    . ARG A 1 547 ? 113.207 110.717 106.753 1.00 61.33  ? 541 ARG A CZ    1 
ATOM 2121 N NH1   . ARG A 1 547 ? 113.386 110.096 107.907 1.00 61.15  ? 541 ARG A NH1   1 
ATOM 2122 N NH2   . ARG A 1 547 ? 113.109 112.042 106.738 1.00 58.53  ? 541 ARG A NH2   1 
ATOM 2123 N N     . TYR A 1 548 ? 112.128 103.393 105.980 1.00 50.26  ? 542 TYR A N     1 
ATOM 2124 C CA    . TYR A 1 548 ? 111.907 102.021 105.539 1.00 47.69  ? 542 TYR A CA    1 
ATOM 2125 C C     . TYR A 1 548 ? 111.097 101.237 106.560 1.00 52.84  ? 542 TYR A C     1 
ATOM 2126 O O     . TYR A 1 548 ? 110.201 100.474 106.188 1.00 57.49  ? 542 TYR A O     1 
ATOM 2127 C CB    . TYR A 1 548 ? 113.226 101.304 105.259 1.00 52.08  ? 542 TYR A CB    1 
ATOM 2128 C CG    . TYR A 1 548 ? 113.012 99.837  104.939 1.00 52.25  ? 542 TYR A CG    1 
ATOM 2129 C CD1   . TYR A 1 548 ? 112.683 99.431  103.655 1.00 53.21  ? 542 TYR A CD1   1 
ATOM 2130 C CD2   . TYR A 1 548 ? 113.114 98.864  105.925 1.00 53.21  ? 542 TYR A CD2   1 
ATOM 2131 C CE1   . TYR A 1 548 ? 112.473 98.100  103.359 1.00 53.61  ? 542 TYR A CE1   1 
ATOM 2132 C CE2   . TYR A 1 548 ? 112.903 97.531  105.638 1.00 54.56  ? 542 TYR A CE2   1 
ATOM 2133 C CZ    . TYR A 1 548 ? 112.584 97.154  104.354 1.00 57.09  ? 542 TYR A CZ    1 
ATOM 2134 O OH    . TYR A 1 548 ? 112.377 95.827  104.062 1.00 57.69  ? 542 TYR A OH    1 
ATOM 2135 N N     . ILE A 1 549 ? 111.405 101.387 107.852 1.00 51.25  ? 543 ILE A N     1 
ATOM 2136 C CA    . ILE A 1 549 ? 110.649 100.609 108.830 1.00 54.41  ? 543 ILE A CA    1 
ATOM 2137 C C     . ILE A 1 549 ? 109.235 101.149 108.971 1.00 56.07  ? 543 ILE A C     1 
ATOM 2138 O O     . ILE A 1 549 ? 108.307 100.388 109.251 1.00 63.54  ? 543 ILE A O     1 
ATOM 2139 C CB    . ILE A 1 549 ? 111.349 100.526 110.201 1.00 53.26  ? 543 ILE A CB    1 
ATOM 2140 C CG1   . ILE A 1 549 ? 111.998 101.842 110.597 1.00 49.07  ? 543 ILE A CG1   1 
ATOM 2141 C CG2   . ILE A 1 549 ? 112.377 99.418  110.200 1.00 54.52  ? 543 ILE A CG2   1 
ATOM 2142 C CD1   . ILE A 1 549 ? 112.791 101.744 111.873 1.00 47.28  ? 543 ILE A CD1   1 
ATOM 2143 N N     . ARG A 1 550 ? 109.031 102.453 108.768 1.00 55.34  ? 544 ARG A N     1 
ATOM 2144 C CA    . ARG A 1 550 ? 107.667 102.973 108.730 1.00 61.98  ? 544 ARG A CA    1 
ATOM 2145 C C     . ARG A 1 550 ? 106.870 102.328 107.598 1.00 64.24  ? 544 ARG A C     1 
ATOM 2146 O O     . ARG A 1 550 ? 105.733 101.874 107.793 1.00 60.97  ? 544 ARG A O     1 
ATOM 2147 C CB    . ARG A 1 550 ? 107.684 104.493 108.574 1.00 58.79  ? 544 ARG A CB    1 
ATOM 2148 C CG    . ARG A 1 550 ? 106.307 105.103 108.376 1.00 61.68  ? 544 ARG A CG    1 
ATOM 2149 C CD    . ARG A 1 550 ? 106.375 106.352 107.517 1.00 65.13  ? 544 ARG A CD    1 
ATOM 2150 N NE    . ARG A 1 550 ? 105.146 106.557 106.759 1.00 67.21  ? 544 ARG A NE    1 
ATOM 2151 C CZ    . ARG A 1 550 ? 105.088 107.143 105.571 1.00 65.11  ? 544 ARG A CZ    1 
ATOM 2152 N NH1   . ARG A 1 550 ? 106.173 107.607 104.975 1.00 63.64  ? 544 ARG A NH1   1 
ATOM 2153 N NH2   . ARG A 1 550 ? 103.910 107.263 104.964 1.00 64.07  ? 544 ARG A NH2   1 
ATOM 2154 N N     . LEU A 1 551 ? 107.464 102.262 106.405 1.00 63.58  ? 545 LEU A N     1 
ATOM 2155 C CA    . LEU A 1 551 ? 106.759 101.672 105.271 1.00 57.60  ? 545 LEU A CA    1 
ATOM 2156 C C     . LEU A 1 551 ? 106.553 100.173 105.461 1.00 59.28  ? 545 LEU A C     1 
ATOM 2157 O O     . LEU A 1 551 ? 105.523 99.627  105.053 1.00 66.17  ? 545 LEU A O     1 
ATOM 2158 C CB    . LEU A 1 551 ? 107.515 101.961 103.975 1.00 58.18  ? 545 LEU A CB    1 
ATOM 2159 C CG    . LEU A 1 551 ? 107.285 103.369 103.419 1.00 58.59  ? 545 LEU A CG    1 
ATOM 2160 C CD1   . LEU A 1 551 ? 107.653 103.442 101.955 1.00 59.64  ? 545 LEU A CD1   1 
ATOM 2161 C CD2   . LEU A 1 551 ? 105.843 103.802 103.630 1.00 63.21  ? 545 LEU A CD2   1 
ATOM 2162 N N     . SER A 1 552 ? 107.515 99.492  106.083 1.00 61.44  ? 546 SER A N     1 
ATOM 2163 C CA    . SER A 1 552 ? 107.352 98.068  106.357 1.00 64.00  ? 546 SER A CA    1 
ATOM 2164 C C     . SER A 1 552 ? 106.281 97.821  107.412 1.00 63.40  ? 546 SER A C     1 
ATOM 2165 O O     . SER A 1 552 ? 105.574 96.810  107.349 1.00 67.70  ? 546 SER A O     1 
ATOM 2166 C CB    . SER A 1 552 ? 108.682 97.462  106.795 1.00 61.83  ? 546 SER A CB    1 
ATOM 2167 O OG    . SER A 1 552 ? 108.845 97.543  108.200 1.00 59.89  ? 546 SER A OG    1 
ATOM 2168 N N     . LYS A 1 553 ? 106.155 98.721  108.387 1.00 62.95  ? 547 LYS A N     1 
ATOM 2169 C CA    . LYS A 1 553 ? 105.063 98.632  109.347 1.00 67.41  ? 547 LYS A CA    1 
ATOM 2170 C C     . LYS A 1 553 ? 103.721 98.829  108.656 1.00 72.15  ? 547 LYS A C     1 
ATOM 2171 O O     . LYS A 1 553 ? 102.736 98.160  108.991 1.00 73.49  ? 547 LYS A O     1 
ATOM 2172 C CB    . LYS A 1 553 ? 105.255 99.668  110.453 1.00 63.96  ? 547 LYS A CB    1 
ATOM 2173 C CG    . LYS A 1 553 ? 106.174 99.220  111.577 1.00 63.66  ? 547 LYS A CG    1 
ATOM 2174 C CD    . LYS A 1 553 ? 105.587 99.564  112.934 1.00 67.22  ? 547 LYS A CD    1 
ATOM 2175 C CE    . LYS A 1 553 ? 105.860 101.010 113.306 1.00 69.95  ? 547 LYS A CE    1 
ATOM 2176 N NZ    . LYS A 1 553 ? 105.339 101.341 114.659 1.00 71.50  ? 547 LYS A NZ    1 
ATOM 2177 N N     . LYS A 1 554 ? 103.662 99.752  107.694 1.00 74.92  ? 548 LYS A N     1 
ATOM 2178 C CA    . LYS A 1 554 ? 102.446 99.901  106.898 1.00 75.55  ? 548 LYS A CA    1 
ATOM 2179 C C     . LYS A 1 554 ? 102.141 98.630  106.113 1.00 73.17  ? 548 LYS A C     1 
ATOM 2180 O O     . LYS A 1 554 ? 100.990 98.180  106.064 1.00 73.56  ? 548 LYS A O     1 
ATOM 2181 C CB    . LYS A 1 554 ? 102.576 101.093 105.951 1.00 75.59  ? 548 LYS A CB    1 
ATOM 2182 C CG    . LYS A 1 554 ? 101.287 101.445 105.222 1.00 75.89  ? 548 LYS A CG    1 
ATOM 2183 C CD    . LYS A 1 554 ? 101.197 102.933 104.927 1.00 77.78  ? 548 LYS A CD    1 
ATOM 2184 C CE    . LYS A 1 554 ? 100.977 103.739 106.198 1.00 75.67  ? 548 LYS A CE    1 
ATOM 2185 N NZ    . LYS A 1 554 ? 99.533  103.854 106.536 1.00 73.28  ? 548 LYS A NZ    1 
ATOM 2186 N N     . LEU A 1 555 ? 103.164 98.036  105.494 1.00 72.18  ? 549 LEU A N     1 
ATOM 2187 C CA    . LEU A 1 555 ? 102.966 96.820  104.709 1.00 73.33  ? 549 LEU A CA    1 
ATOM 2188 C C     . LEU A 1 555 ? 102.482 95.665  105.575 1.00 76.36  ? 549 LEU A C     1 
ATOM 2189 O O     . LEU A 1 555 ? 101.596 94.904  105.169 1.00 78.35  ? 549 LEU A O     1 
ATOM 2190 C CB    . LEU A 1 555 ? 104.263 96.440  103.995 1.00 71.02  ? 549 LEU A CB    1 
ATOM 2191 C CG    . LEU A 1 555 ? 104.553 97.169  102.686 1.00 74.54  ? 549 LEU A CG    1 
ATOM 2192 C CD1   . LEU A 1 555 ? 105.681 96.489  101.936 1.00 72.27  ? 549 LEU A CD1   1 
ATOM 2193 C CD2   . LEU A 1 555 ? 103.299 97.195  101.838 1.00 75.34  ? 549 LEU A CD2   1 
ATOM 2194 N N     . ARG A 1 556 ? 103.060 95.507  106.766 1.00 72.83  ? 550 ARG A N     1 
ATOM 2195 C CA    . ARG A 1 556 ? 102.658 94.408  107.638 1.00 71.81  ? 550 ARG A CA    1 
ATOM 2196 C C     . ARG A 1 556 ? 101.231 94.583  108.139 1.00 72.61  ? 550 ARG A C     1 
ATOM 2197 O O     . ARG A 1 556 ? 100.504 93.595  108.297 1.00 73.78  ? 550 ARG A O     1 
ATOM 2198 C CB    . ARG A 1 556 ? 103.630 94.288  108.811 1.00 68.04  ? 550 ARG A CB    1 
ATOM 2199 C CG    . ARG A 1 556 ? 103.287 93.186  109.802 1.00 69.06  ? 550 ARG A CG    1 
ATOM 2200 C CD    . ARG A 1 556 ? 102.889 93.758  111.151 1.00 72.55  ? 550 ARG A CD    1 
ATOM 2201 N NE    . ARG A 1 556 ? 103.738 94.878  111.541 1.00 73.98  ? 550 ARG A NE    1 
ATOM 2202 C CZ    . ARG A 1 556 ? 103.684 95.482  112.719 1.00 69.67  ? 550 ARG A CZ    1 
ATOM 2203 N NH1   . ARG A 1 556 ? 102.840 95.092  113.659 1.00 73.44  ? 550 ARG A NH1   1 
ATOM 2204 N NH2   . ARG A 1 556 ? 104.502 96.502  112.962 1.00 62.50  ? 550 ARG A NH2   1 
ATOM 2205 N N     . ASP A 1 557 ? 100.807 95.823  108.381 1.00 78.24  ? 551 ASP A N     1 
ATOM 2206 C CA    . ASP A 1 557 ? 99.481  96.089  108.931 1.00 82.53  ? 551 ASP A CA    1 
ATOM 2207 C C     . ASP A 1 557 ? 98.445  96.322  107.833 1.00 82.35  ? 551 ASP A C     1 
ATOM 2208 O O     . ASP A 1 557 ? 97.444  95.604  107.751 1.00 80.33  ? 551 ASP A O     1 
ATOM 2209 C CB    . ASP A 1 557 ? 99.542  97.294  109.875 1.00 81.75  ? 551 ASP A CB    1 
ATOM 2210 C CG    . ASP A 1 557 ? 100.404 97.034  111.093 1.00 83.04  ? 551 ASP A CG    1 
ATOM 2211 O OD1   . ASP A 1 557 ? 100.291 95.936  111.677 1.00 83.36  ? 551 ASP A OD1   1 
ATOM 2212 O OD2   . ASP A 1 557 ? 101.196 97.925  111.463 1.00 84.57  ? 551 ASP A OD2   1 
ATOM 2213 N N     . ARG A 1 558 ? 98.673  97.327  106.983 1.00 85.76  ? 552 ARG A N     1 
ATOM 2214 C CA    . ARG A 1 558 ? 97.688  97.665  105.961 1.00 85.55  ? 552 ARG A CA    1 
ATOM 2215 C C     . ARG A 1 558 ? 97.636  96.608  104.864 1.00 86.56  ? 552 ARG A C     1 
ATOM 2216 O O     . ARG A 1 558 ? 96.559  96.301  104.340 1.00 85.81  ? 552 ARG A O     1 
ATOM 2217 C CB    . ARG A 1 558 ? 97.997  99.039  105.368 1.00 85.18  ? 552 ARG A CB    1 
ATOM 2218 C CG    . ARG A 1 558 ? 96.788  99.767  104.803 1.00 85.61  ? 552 ARG A CG    1 
ATOM 2219 C CD    . ARG A 1 558 ? 95.599  99.695  105.749 1.00 85.74  ? 552 ARG A CD    1 
ATOM 2220 N NE    . ARG A 1 558 ? 95.936  100.150 107.093 1.00 86.37  ? 552 ARG A NE    1 
ATOM 2221 C CZ    . ARG A 1 558 ? 95.957  101.421 107.471 1.00 85.88  ? 552 ARG A CZ    1 
ATOM 2222 N NH1   . ARG A 1 558 ? 95.669  102.398 106.626 1.00 81.65  ? 552 ARG A NH1   1 
ATOM 2223 N NH2   . ARG A 1 558 ? 96.275  101.719 108.727 1.00 85.02  ? 552 ARG A NH2   1 
ATOM 2224 N N     . GLY A 1 559 ? 98.787  96.041  104.504 1.00 82.65  ? 553 GLY A N     1 
ATOM 2225 C CA    . GLY A 1 559 ? 98.853  95.025  103.477 1.00 80.36  ? 553 GLY A CA    1 
ATOM 2226 C C     . GLY A 1 559 ? 99.074  95.544  102.073 1.00 82.15  ? 553 GLY A C     1 
ATOM 2227 O O     . GLY A 1 559 ? 99.294  94.735  101.162 1.00 83.42  ? 553 GLY A O     1 
ATOM 2228 N N     . ALA A 1 560 ? 99.028  96.857  101.868 1.00 76.11  ? 554 ALA A N     1 
ATOM 2229 C CA    . ALA A 1 560 ? 99.233  97.432  100.547 1.00 74.03  ? 554 ALA A CA    1 
ATOM 2230 C C     . ALA A 1 560 ? 99.717  98.864  100.699 1.00 76.47  ? 554 ALA A C     1 
ATOM 2231 O O     . ALA A 1 560 ? 99.541  99.492  101.746 1.00 80.68  ? 554 ALA A O     1 
ATOM 2232 C CB    . ALA A 1 560 ? 97.951  97.384  99.704  1.00 74.18  ? 554 ALA A CB    1 
ATOM 2233 N N     . LEU A 1 561 ? 100.326 99.377  99.636  1.00 78.82  ? 555 LEU A N     1 
ATOM 2234 C CA    . LEU A 1 561 ? 100.876 100.722 99.619  1.00 81.50  ? 555 LEU A CA    1 
ATOM 2235 C C     . LEU A 1 561 ? 100.192 101.563 98.550  1.00 79.06  ? 555 LEU A C     1 
ATOM 2236 O O     . LEU A 1 561 ? 99.620  101.044 97.587  1.00 75.42  ? 555 LEU A O     1 
ATOM 2237 C CB    . LEU A 1 561 ? 102.389 100.705 99.366  1.00 78.90  ? 555 LEU A CB    1 
ATOM 2238 C CG    . LEU A 1 561 ? 103.305 100.532 100.578 1.00 78.30  ? 555 LEU A CG    1 
ATOM 2239 C CD1   . LEU A 1 561 ? 104.709 101.010 100.251 1.00 78.24  ? 555 LEU A CD1   1 
ATOM 2240 C CD2   . LEU A 1 561 ? 102.754 101.269 101.786 1.00 79.47  ? 555 LEU A CD2   1 
ATOM 2241 N N     . ASN A 1 562 ? 100.259 102.878 98.737  1.00 90.98  ? 556 ASN A N     1 
ATOM 2242 C CA    . ASN A 1 562 ? 99.801  103.805 97.718  1.00 92.95  ? 556 ASN A CA    1 
ATOM 2243 C C     . ASN A 1 562 ? 100.785 103.820 96.549  1.00 91.13  ? 556 ASN A C     1 
ATOM 2244 O O     . ASN A 1 562 ? 101.891 103.277 96.620  1.00 91.66  ? 556 ASN A O     1 
ATOM 2245 C CB    . ASN A 1 562 ? 99.639  105.207 98.301  1.00 93.37  ? 556 ASN A CB    1 
ATOM 2246 C CG    . ASN A 1 562 ? 98.279  105.422 98.935  1.00 93.40  ? 556 ASN A CG    1 
ATOM 2247 O OD1   . ASN A 1 562 ? 97.276  104.873 98.481  1.00 92.34  ? 556 ASN A OD1   1 
ATOM 2248 N ND2   . ASN A 1 562 ? 98.240  106.224 99.992  1.00 92.69  ? 556 ASN A ND2   1 
ATOM 2249 N N     . ASP A 1 563 ? 100.364 104.454 95.454  1.00 92.82  ? 557 ASP A N     1 
ATOM 2250 C CA    . ASP A 1 563 ? 101.200 104.496 94.259  1.00 95.64  ? 557 ASP A CA    1 
ATOM 2251 C C     . ASP A 1 563 ? 102.503 105.239 94.519  1.00 94.03  ? 557 ASP A C     1 
ATOM 2252 O O     . ASP A 1 563 ? 103.567 104.829 94.042  1.00 92.32  ? 557 ASP A O     1 
ATOM 2253 C CB    . ASP A 1 563 ? 100.433 105.140 93.105  1.00 95.00  ? 557 ASP A CB    1 
ATOM 2254 C CG    . ASP A 1 563 ? 100.850 104.597 91.753  1.00 96.57  ? 557 ASP A CG    1 
ATOM 2255 O OD1   . ASP A 1 563 ? 102.069 104.508 91.499  1.00 97.87  ? 557 ASP A OD1   1 
ATOM 2256 O OD2   . ASP A 1 563 ? 99.960  104.259 90.945  1.00 95.12  ? 557 ASP A OD2   1 
ATOM 2257 N N     . ILE A 1 564 ? 102.440 106.342 95.268  1.00 87.38  ? 558 ILE A N     1 
ATOM 2258 C CA    . ILE A 1 564 ? 103.640 107.128 95.534  1.00 86.55  ? 558 ILE A CA    1 
ATOM 2259 C C     . ILE A 1 564 ? 104.578 106.386 96.482  1.00 88.66  ? 558 ILE A C     1 
ATOM 2260 O O     . ILE A 1 564 ? 105.796 106.352 96.266  1.00 89.35  ? 558 ILE A O     1 
ATOM 2261 C CB    . ILE A 1 564 ? 103.256 108.517 96.077  1.00 85.02  ? 558 ILE A CB    1 
ATOM 2262 C CG1   . ILE A 1 564 ? 104.494 109.251 96.598  1.00 83.62  ? 558 ILE A CG1   1 
ATOM 2263 C CG2   . ILE A 1 564 ? 102.189 108.396 97.154  1.00 87.74  ? 558 ILE A CG2   1 
ATOM 2264 C CD1   . ILE A 1 564 ? 105.455 109.666 95.509  1.00 81.77  ? 558 ILE A CD1   1 
ATOM 2265 N N     . GLU A 1 565 ? 104.033 105.780 97.540  1.00 85.13  ? 559 GLU A N     1 
ATOM 2266 C CA    . GLU A 1 565 ? 104.878 105.132 98.538  1.00 84.18  ? 559 GLU A CA    1 
ATOM 2267 C C     . GLU A 1 565 ? 105.605 103.923 97.958  1.00 83.60  ? 559 GLU A C     1 
ATOM 2268 O O     . GLU A 1 565 ? 106.800 103.734 98.214  1.00 83.38  ? 559 GLU A O     1 
ATOM 2269 C CB    . GLU A 1 565 ? 104.046 104.723 99.752  1.00 83.25  ? 559 GLU A CB    1 
ATOM 2270 C CG    . GLU A 1 565 ? 103.472 105.894 100.531 1.00 85.27  ? 559 GLU A CG    1 
ATOM 2271 C CD    . GLU A 1 565 ? 102.783 105.462 101.808 1.00 86.16  ? 559 GLU A CD    1 
ATOM 2272 O OE1   . GLU A 1 565 ? 101.812 104.679 101.728 1.00 86.81  ? 559 GLU A OE1   1 
ATOM 2273 O OE2   . GLU A 1 565 ? 103.212 105.904 102.894 1.00 81.82  ? 559 GLU A OE2   1 
ATOM 2274 N N     . ALA A 1 566 ? 104.904 103.095 97.182  1.00 78.59  ? 560 ALA A N     1 
ATOM 2275 C CA    . ALA A 1 566 ? 105.544 101.926 96.587  1.00 76.12  ? 560 ALA A CA    1 
ATOM 2276 C C     . ALA A 1 566 ? 106.659 102.337 95.636  1.00 76.19  ? 560 ALA A C     1 
ATOM 2277 O O     . ALA A 1 566 ? 107.722 101.709 95.602  1.00 79.63  ? 560 ALA A O     1 
ATOM 2278 C CB    . ALA A 1 566 ? 104.508 101.068 95.864  1.00 76.96  ? 560 ALA A CB    1 
ATOM 2279 N N     . ARG A 1 567 ? 106.429 103.389 94.848  1.00 77.54  ? 561 ARG A N     1 
ATOM 2280 C CA    . ARG A 1 567 ? 107.497 103.937 94.019  1.00 79.90  ? 561 ARG A CA    1 
ATOM 2281 C C     . ARG A 1 567 ? 108.618 104.512 94.875  1.00 79.51  ? 561 ARG A C     1 
ATOM 2282 O O     . ARG A 1 567 ? 109.800 104.336 94.562  1.00 77.73  ? 561 ARG A O     1 
ATOM 2283 C CB    . ARG A 1 567 ? 106.934 105.003 93.080  1.00 80.00  ? 561 ARG A CB    1 
ATOM 2284 C CG    . ARG A 1 567 ? 107.937 105.551 92.083  1.00 76.66  ? 561 ARG A CG    1 
ATOM 2285 C CD    . ARG A 1 567 ? 108.080 107.054 92.235  1.00 80.13  ? 561 ARG A CD    1 
ATOM 2286 N NE    . ARG A 1 567 ? 106.797 107.736 92.107  1.00 81.45  ? 561 ARG A NE    1 
ATOM 2287 C CZ    . ARG A 1 567 ? 106.634 109.048 92.205  1.00 82.15  ? 561 ARG A CZ    1 
ATOM 2288 N NH1   . ARG A 1 567 ? 107.654 109.857 92.433  1.00 81.14  ? 561 ARG A NH1   1 
ATOM 2289 N NH2   . ARG A 1 567 ? 105.414 109.561 92.072  1.00 83.17  ? 561 ARG A NH2   1 
ATOM 2290 N N     . LEU A 1 568 ? 108.263 105.205 95.959  1.00 72.90  ? 562 LEU A N     1 
ATOM 2291 C CA    . LEU A 1 568 ? 109.278 105.773 96.842  1.00 70.26  ? 562 LEU A CA    1 
ATOM 2292 C C     . LEU A 1 568 ? 110.106 104.685 97.510  1.00 71.76  ? 562 LEU A C     1 
ATOM 2293 O O     . LEU A 1 568 ? 111.333 104.802 97.612  1.00 72.09  ? 562 LEU A O     1 
ATOM 2294 C CB    . LEU A 1 568 ? 108.613 106.661 97.894  1.00 67.96  ? 562 LEU A CB    1 
ATOM 2295 C CG    . LEU A 1 568 ? 109.288 107.997 98.204  1.00 68.55  ? 562 LEU A CG    1 
ATOM 2296 C CD1   . LEU A 1 568 ? 109.766 108.670 96.929  1.00 70.62  ? 562 LEU A CD1   1 
ATOM 2297 C CD2   . LEU A 1 568 ? 108.334 108.902 98.964  1.00 69.24  ? 562 LEU A CD2   1 
ATOM 2298 N N     . LEU A 1 569 ? 109.451 103.620 97.976  1.00 69.01  ? 563 LEU A N     1 
ATOM 2299 C CA    . LEU A 1 569 ? 110.157 102.565 98.700  1.00 64.76  ? 563 LEU A CA    1 
ATOM 2300 C C     . LEU A 1 569 ? 111.150 101.841 97.801  1.00 65.72  ? 563 LEU A C     1 
ATOM 2301 O O     . LEU A 1 569 ? 112.301 101.610 98.190  1.00 67.84  ? 563 LEU A O     1 
ATOM 2302 C CB    . LEU A 1 569 ? 109.145 101.587 99.300  1.00 62.24  ? 563 LEU A CB    1 
ATOM 2303 C CG    . LEU A 1 569 ? 109.601 100.208 99.776  1.00 61.46  ? 563 LEU A CG    1 
ATOM 2304 C CD1   . LEU A 1 569 ? 108.825 99.820  101.019 1.00 61.29  ? 563 LEU A CD1   1 
ATOM 2305 C CD2   . LEU A 1 569 ? 109.397 99.162  98.693  1.00 65.43  ? 563 LEU A CD2   1 
ATOM 2306 N N     . GLU A 1 570 ? 110.724 101.472 96.594  1.00 69.62  ? 564 GLU A N     1 
ATOM 2307 C CA    . GLU A 1 570 ? 111.590 100.705 95.706  1.00 66.49  ? 564 GLU A CA    1 
ATOM 2308 C C     . GLU A 1 570 ? 112.685 101.567 95.094  1.00 69.87  ? 564 GLU A C     1 
ATOM 2309 O O     . GLU A 1 570 ? 113.838 101.133 94.994  1.00 73.08  ? 564 GLU A O     1 
ATOM 2310 C CB    . GLU A 1 570 ? 110.758 100.045 94.605  1.00 69.33  ? 564 GLU A CB    1 
ATOM 2311 C CG    . GLU A 1 570 ? 110.112 98.732  95.015  1.00 72.56  ? 564 GLU A CG    1 
ATOM 2312 C CD    . GLU A 1 570 ? 111.125 97.634  95.260  1.00 78.49  ? 564 GLU A CD    1 
ATOM 2313 O OE1   . GLU A 1 570 ? 112.051 97.480  94.436  1.00 81.32  ? 564 GLU A OE1   1 
ATOM 2314 O OE2   . GLU A 1 570 ? 110.997 96.920  96.278  1.00 77.49  ? 564 GLU A OE2   1 
ATOM 2315 N N     . GLU A 1 571 ? 112.350 102.790 94.678  1.00 73.06  ? 565 GLU A N     1 
ATOM 2316 C CA    . GLU A 1 571 ? 113.316 103.628 93.977  1.00 76.86  ? 565 GLU A CA    1 
ATOM 2317 C C     . GLU A 1 571 ? 114.332 104.252 94.927  1.00 74.34  ? 565 GLU A C     1 
ATOM 2318 O O     . GLU A 1 571 ? 115.499 104.425 94.558  1.00 75.18  ? 565 GLU A O     1 
ATOM 2319 C CB    . GLU A 1 571 ? 112.592 104.723 93.192  1.00 82.28  ? 565 GLU A CB    1 
ATOM 2320 C CG    . GLU A 1 571 ? 112.257 104.350 91.757  1.00 80.69  ? 565 GLU A CG    1 
ATOM 2321 C CD    . GLU A 1 571 ? 112.073 105.567 90.870  1.00 80.42  ? 565 GLU A CD    1 
ATOM 2322 O OE1   . GLU A 1 571 ? 111.068 106.286 91.047  1.00 79.91  ? 565 GLU A OE1   1 
ATOM 2323 O OE2   . GLU A 1 571 ? 112.935 105.806 89.998  1.00 78.75  ? 565 GLU A OE2   1 
ATOM 2324 N N     . LYS A 1 572 ? 113.915 104.607 96.141  1.00 63.24  ? 566 LYS A N     1 
ATOM 2325 C CA    . LYS A 1 572 ? 114.753 105.402 97.030  1.00 63.64  ? 566 LYS A CA    1 
ATOM 2326 C C     . LYS A 1 572 ? 115.104 104.694 98.328  1.00 66.26  ? 566 LYS A C     1 
ATOM 2327 O O     . LYS A 1 572 ? 116.277 104.677 98.718  1.00 65.06  ? 566 LYS A O     1 
ATOM 2328 C CB    . LYS A 1 572 ? 114.062 106.738 97.337  1.00 61.61  ? 566 LYS A CB    1 
ATOM 2329 C CG    . LYS A 1 572 ? 114.876 107.661 98.223  1.00 64.65  ? 566 LYS A CG    1 
ATOM 2330 C CD    . LYS A 1 572 ? 116.180 108.052 97.550  1.00 63.17  ? 566 LYS A CD    1 
ATOM 2331 C CE    . LYS A 1 572 ? 116.110 109.464 96.995  1.00 64.13  ? 566 LYS A CE    1 
ATOM 2332 N NZ    . LYS A 1 572 ? 115.833 110.464 98.061  1.00 62.40  ? 566 LYS A NZ    1 
ATOM 2333 N N     . TYR A 1 573 ? 114.123 104.112 99.019  1.00 62.77  ? 567 TYR A N     1 
ATOM 2334 C CA    . TYR A 1 573 ? 114.381 103.602 100.363 1.00 56.89  ? 567 TYR A CA    1 
ATOM 2335 C C     . TYR A 1 573 ? 115.193 102.313 100.334 1.00 58.11  ? 567 TYR A C     1 
ATOM 2336 O O     . TYR A 1 573 ? 116.072 102.111 101.177 1.00 63.84  ? 567 TYR A O     1 
ATOM 2337 C CB    . TYR A 1 573 ? 113.062 103.399 101.109 1.00 51.47  ? 567 TYR A CB    1 
ATOM 2338 C CG    . TYR A 1 573 ? 112.333 104.690 101.412 1.00 55.92  ? 567 TYR A CG    1 
ATOM 2339 C CD1   . TYR A 1 573 ? 112.958 105.919 101.246 1.00 57.10  ? 567 TYR A CD1   1 
ATOM 2340 C CD2   . TYR A 1 573 ? 111.022 104.680 101.863 1.00 57.64  ? 567 TYR A CD2   1 
ATOM 2341 C CE1   . TYR A 1 573 ? 112.297 107.097 101.515 1.00 53.81  ? 567 TYR A CE1   1 
ATOM 2342 C CE2   . TYR A 1 573 ? 110.354 105.855 102.136 1.00 57.25  ? 567 TYR A CE2   1 
ATOM 2343 C CZ    . TYR A 1 573 ? 110.998 107.059 101.961 1.00 56.77  ? 567 TYR A CZ    1 
ATOM 2344 O OH    . TYR A 1 573 ? 110.337 108.234 102.233 1.00 59.93  ? 567 TYR A OH    1 
ATOM 2345 N N     . ILE A 1 574 ? 114.907 101.422 99.381  1.00 63.48  ? 568 ILE A N     1 
ATOM 2346 C CA    . ILE A 1 574 ? 115.662 100.169 99.292  1.00 61.05  ? 568 ILE A CA    1 
ATOM 2347 C C     . ILE A 1 574 ? 117.139 100.406 98.997  1.00 62.42  ? 568 ILE A C     1 
ATOM 2348 O O     . ILE A 1 574 ? 117.984 99.832  99.703  1.00 68.03  ? 568 ILE A O     1 
ATOM 2349 C CB    . ILE A 1 574 ? 114.997 99.220  98.280  1.00 61.78  ? 568 ILE A CB    1 
ATOM 2350 C CG1   . ILE A 1 574 ? 113.688 98.669  98.846  1.00 61.47  ? 568 ILE A CG1   1 
ATOM 2351 C CG2   . ILE A 1 574 ? 115.935 98.081  97.923  1.00 58.28  ? 568 ILE A CG2   1 
ATOM 2352 C CD1   . ILE A 1 574 ? 113.868 97.881  100.116 1.00 59.93  ? 568 ILE A CD1   1 
ATOM 2353 N N     . PRO A 1 575 ? 117.526 101.212 98.000  1.00 58.66  ? 569 PRO A N     1 
ATOM 2354 C CA    . PRO A 1 575 ? 118.962 101.474 97.809  1.00 61.16  ? 569 PRO A CA    1 
ATOM 2355 C C     . PRO A 1 575 ? 119.570 102.339 98.897  1.00 65.01  ? 569 PRO A C     1 
ATOM 2356 O O     . PRO A 1 575 ? 120.801 102.379 99.013  1.00 69.18  ? 569 PRO A O     1 
ATOM 2357 C CB    . PRO A 1 575 ? 119.014 102.174 96.447  1.00 62.40  ? 569 PRO A CB    1 
ATOM 2358 C CG    . PRO A 1 575 ? 117.696 102.822 96.321  1.00 64.73  ? 569 PRO A CG    1 
ATOM 2359 C CD    . PRO A 1 575 ? 116.725 101.867 96.950  1.00 62.34  ? 569 PRO A CD    1 
ATOM 2360 N N     . GLY A 1 576 ? 118.759 103.031 99.691  1.00 60.94  ? 570 GLY A N     1 
ATOM 2361 C CA    . GLY A 1 576 ? 119.275 103.870 100.754 1.00 58.74  ? 570 GLY A CA    1 
ATOM 2362 C C     . GLY A 1 576 ? 119.575 103.094 102.019 1.00 59.17  ? 570 GLY A C     1 
ATOM 2363 O O     . GLY A 1 576 ? 120.681 103.179 102.561 1.00 63.61  ? 570 GLY A O     1 
ATOM 2364 N N     . PHE A 1 577 ? 118.593 102.331 102.497 1.00 49.19  ? 571 PHE A N     1 
ATOM 2365 C CA    . PHE A 1 577 ? 118.794 101.469 103.656 1.00 39.05  ? 571 PHE A CA    1 
ATOM 2366 C C     . PHE A 1 577 ? 119.720 100.300 103.356 1.00 47.91  ? 571 PHE A C     1 
ATOM 2367 O O     . PHE A 1 577 ? 120.172 99.636  104.295 1.00 54.62  ? 571 PHE A O     1 
ATOM 2368 C CB    . PHE A 1 577 ? 117.446 100.947 104.155 1.00 49.26  ? 571 PHE A CB    1 
ATOM 2369 C CG    . PHE A 1 577 ? 117.463 100.470 105.579 1.00 52.45  ? 571 PHE A CG    1 
ATOM 2370 C CD1   . PHE A 1 577 ? 118.443 100.893 106.460 1.00 53.45  ? 571 PHE A CD1   1 
ATOM 2371 C CD2   . PHE A 1 577 ? 116.493 99.597  106.040 1.00 51.45  ? 571 PHE A CD2   1 
ATOM 2372 C CE1   . PHE A 1 577 ? 118.452 100.452 107.767 1.00 55.21  ? 571 PHE A CE1   1 
ATOM 2373 C CE2   . PHE A 1 577 ? 116.500 99.154  107.347 1.00 44.55  ? 571 PHE A CE2   1 
ATOM 2374 C CZ    . PHE A 1 577 ? 117.480 99.583  108.211 1.00 43.14  ? 571 PHE A CZ    1 
ATOM 2375 N N     . ARG A 1 578 ? 120.010 100.036 102.080 1.00 53.51  ? 572 ARG A N     1 
ATOM 2376 C CA    . ARG A 1 578 ? 120.865 98.921  101.673 1.00 55.43  ? 572 ARG A CA    1 
ATOM 2377 C C     . ARG A 1 578 ? 120.344 97.600  102.231 1.00 51.45  ? 572 ARG A C     1 
ATOM 2378 O O     . ARG A 1 578 ? 121.103 96.746  102.691 1.00 58.76  ? 572 ARG A O     1 
ATOM 2379 C CB    . ARG A 1 578 ? 122.318 99.161  102.084 1.00 55.07  ? 572 ARG A CB    1 
ATOM 2380 C CG    . ARG A 1 578 ? 122.952 100.366 101.411 1.00 51.94  ? 572 ARG A CG    1 
ATOM 2381 C CD    . ARG A 1 578 ? 124.321 100.028 100.849 1.00 57.58  ? 572 ARG A CD    1 
ATOM 2382 N NE    . ARG A 1 578 ? 125.095 99.205  101.771 1.00 62.10  ? 572 ARG A NE    1 
ATOM 2383 C CZ    . ARG A 1 578 ? 125.841 99.686  102.755 1.00 61.61  ? 572 ARG A CZ    1 
ATOM 2384 N NH1   . ARG A 1 578 ? 125.947 100.987 102.970 1.00 56.82  ? 572 ARG A NH1   1 
ATOM 2385 N NH2   . ARG A 1 578 ? 126.499 98.841  103.544 1.00 57.10  ? 572 ARG A NH2   1 
ATOM 2386 N N     . ILE A 1 579 ? 119.027 97.436  102.186 1.00 52.95  ? 573 ILE A N     1 
ATOM 2387 C CA    . ILE A 1 579 ? 118.364 96.233  102.660 1.00 57.84  ? 573 ILE A CA    1 
ATOM 2388 C C     . ILE A 1 579 ? 117.778 95.503  101.460 1.00 62.65  ? 573 ILE A C     1 
ATOM 2389 O O     . ILE A 1 579 ? 117.609 96.068  100.375 1.00 65.49  ? 573 ILE A O     1 
ATOM 2390 C CB    . ILE A 1 579 ? 117.271 96.562  103.702 1.00 56.65  ? 573 ILE A CB    1 
ATOM 2391 C CG1   . ILE A 1 579 ? 116.929 95.337  104.552 1.00 54.95  ? 573 ILE A CG1   1 
ATOM 2392 C CG2   . ILE A 1 579 ? 116.027 97.097  103.017 1.00 56.19  ? 573 ILE A CG2   1 
ATOM 2393 C CD1   . ILE A 1 579 ? 116.336 95.684  105.896 1.00 57.01  ? 573 ILE A CD1   1 
ATOM 2394 N N     . VAL A 1 580 ? 117.479 94.224  101.655 1.00 65.75  ? 574 VAL A N     1 
ATOM 2395 C CA    . VAL A 1 580 ? 116.796 93.413  100.654 1.00 64.21  ? 574 VAL A CA    1 
ATOM 2396 C C     . VAL A 1 580 ? 115.337 93.281  101.065 1.00 63.16  ? 574 VAL A C     1 
ATOM 2397 O O     . VAL A 1 580 ? 115.035 92.884  102.198 1.00 66.97  ? 574 VAL A O     1 
ATOM 2398 C CB    . VAL A 1 580 ? 117.465 92.036  100.492 1.00 62.62  ? 574 VAL A CB    1 
ATOM 2399 C CG1   . VAL A 1 580 ? 118.772 92.178  99.733  1.00 62.69  ? 574 VAL A CG1   1 
ATOM 2400 C CG2   . VAL A 1 580 ? 117.718 91.398  101.849 1.00 66.42  ? 574 VAL A CG2   1 
ATOM 2401 N N     . HIS A 1 581 ? 114.432 93.633  100.158 1.00 65.07  ? 575 HIS A N     1 
ATOM 2402 C CA    . HIS A 1 581 ? 113.012 93.656  100.478 1.00 68.04  ? 575 HIS A CA    1 
ATOM 2403 C C     . HIS A 1 581 ? 112.452 92.240  100.442 1.00 72.92  ? 575 HIS A C     1 
ATOM 2404 O O     . HIS A 1 581 ? 112.520 91.565  99.410  1.00 75.18  ? 575 HIS A O     1 
ATOM 2405 C CB    . HIS A 1 581 ? 112.260 94.560  99.508  1.00 67.36  ? 575 HIS A CB    1 
ATOM 2406 C CG    . HIS A 1 581 ? 110.981 95.104  100.063 1.00 71.26  ? 575 HIS A CG    1 
ATOM 2407 N ND1   . HIS A 1 581 ? 109.759 94.894  99.464  1.00 74.08  ? 575 HIS A ND1   1 
ATOM 2408 C CD2   . HIS A 1 581 ? 110.736 95.848  101.168 1.00 70.12  ? 575 HIS A CD2   1 
ATOM 2409 C CE1   . HIS A 1 581 ? 108.815 95.485  100.175 1.00 74.43  ? 575 HIS A CE1   1 
ATOM 2410 N NE2   . HIS A 1 581 ? 109.382 96.072  101.214 1.00 72.64  ? 575 HIS A NE2   1 
ATOM 2411 N N     . ILE A 1 582 ? 111.894 91.797  101.566 1.00 73.25  ? 576 ILE A N     1 
ATOM 2412 C CA    . ILE A 1 582 ? 111.290 90.477  101.695 1.00 71.73  ? 576 ILE A CA    1 
ATOM 2413 C C     . ILE A 1 582 ? 109.779 90.645  101.738 1.00 71.69  ? 576 ILE A C     1 
ATOM 2414 O O     . ILE A 1 582 ? 109.263 91.529  102.429 1.00 71.27  ? 576 ILE A O     1 
ATOM 2415 C CB    . ILE A 1 582 ? 111.779 89.718  102.947 1.00 72.13  ? 576 ILE A CB    1 
ATOM 2416 C CG1   . ILE A 1 582 ? 113.299 89.812  103.147 1.00 69.50  ? 576 ILE A CG1   1 
ATOM 2417 C CG2   . ILE A 1 582 ? 111.350 88.265  102.872 1.00 69.53  ? 576 ILE A CG2   1 
ATOM 2418 C CD1   . ILE A 1 582 ? 114.143 89.750  101.884 1.00 68.15  ? 576 ILE A CD1   1 
ATOM 2419 N N     . GLU A 1 583 ? 109.073 89.794  100.992 1.00 78.62  ? 577 GLU A N     1 
ATOM 2420 C CA    . GLU A 1 583 ? 107.616 89.870  100.968 1.00 79.62  ? 577 GLU A CA    1 
ATOM 2421 C C     . GLU A 1 583 ? 107.009 89.338  102.260 1.00 81.33  ? 577 GLU A C     1 
ATOM 2422 O O     . GLU A 1 583 ? 105.996 89.863  102.739 1.00 81.49  ? 577 GLU A O     1 
ATOM 2423 C CB    . GLU A 1 583 ? 107.074 89.106  99.762  1.00 78.79  ? 577 GLU A CB    1 
ATOM 2424 C CG    . GLU A 1 583 ? 107.428 89.736  98.427  1.00 81.88  ? 577 GLU A CG    1 
ATOM 2425 C CD    . GLU A 1 583 ? 108.668 89.126  97.803  1.00 84.38  ? 577 GLU A CD    1 
ATOM 2426 O OE1   . GLU A 1 583 ? 109.032 87.993  98.181  1.00 81.41  ? 577 GLU A OE1   1 
ATOM 2427 O OE2   . GLU A 1 583 ? 109.279 89.781  96.934  1.00 83.46  ? 577 GLU A OE2   1 
ATOM 2428 N N     . ASP A 1 584 ? 107.604 88.295  102.836 1.00 80.17  ? 578 ASP A N     1 
ATOM 2429 C CA    . ASP A 1 584 ? 107.094 87.729  104.077 1.00 80.84  ? 578 ASP A CA    1 
ATOM 2430 C C     . ASP A 1 584 ? 107.331 88.695  105.232 1.00 84.38  ? 578 ASP A C     1 
ATOM 2431 O O     . ASP A 1 584 ? 108.460 89.131  105.470 1.00 82.73  ? 578 ASP A O     1 
ATOM 2432 C CB    . ASP A 1 584 ? 107.762 86.385  104.362 1.00 80.18  ? 578 ASP A CB    1 
ATOM 2433 C CG    . ASP A 1 584 ? 107.239 85.730  105.624 1.00 82.16  ? 578 ASP A CG    1 
ATOM 2434 O OD1   . ASP A 1 584 ? 106.027 85.846  105.898 1.00 85.06  ? 578 ASP A OD1   1 
ATOM 2435 O OD2   . ASP A 1 584 ? 108.041 85.095  106.340 1.00 79.14  ? 578 ASP A OD2   1 
ATOM 2436 N N     . ALA A 1 585 ? 106.259 89.027  105.953 1.00 75.82  ? 579 ALA A N     1 
ATOM 2437 C CA    . ALA A 1 585 ? 106.344 90.009  107.024 1.00 72.29  ? 579 ALA A CA    1 
ATOM 2438 C C     . ALA A 1 585 ? 106.991 89.460  108.289 1.00 70.50  ? 579 ALA A C     1 
ATOM 2439 O O     . ALA A 1 585 ? 107.479 90.247  109.106 1.00 67.91  ? 579 ALA A O     1 
ATOM 2440 C CB    . ALA A 1 585 ? 104.953 90.550  107.356 1.00 70.60  ? 579 ALA A CB    1 
ATOM 2441 N N     . ASP A 1 586 ? 107.002 88.141  108.473 1.00 74.84  ? 580 ASP A N     1 
ATOM 2442 C CA    . ASP A 1 586 ? 107.573 87.574  109.690 1.00 77.47  ? 580 ASP A CA    1 
ATOM 2443 C C     . ASP A 1 586 ? 109.093 87.697  109.697 1.00 77.84  ? 580 ASP A C     1 
ATOM 2444 O O     . ASP A 1 586 ? 109.686 88.115  110.697 1.00 78.00  ? 580 ASP A O     1 
ATOM 2445 C CB    . ASP A 1 586 ? 107.146 86.114  109.839 1.00 77.68  ? 580 ASP A CB    1 
ATOM 2446 C CG    . ASP A 1 586 ? 106.853 85.738  111.278 1.00 76.42  ? 580 ASP A CG    1 
ATOM 2447 O OD1   . ASP A 1 586 ? 107.002 86.607  112.162 1.00 78.06  ? 580 ASP A OD1   1 
ATOM 2448 O OD2   . ASP A 1 586 ? 106.472 84.575  111.526 1.00 75.16  ? 580 ASP A OD2   1 
ATOM 2449 N N     . GLU A 1 587 ? 109.740 87.340  108.587 1.00 79.14  ? 581 GLU A N     1 
ATOM 2450 C CA    . GLU A 1 587 ? 111.190 87.441  108.475 1.00 80.63  ? 581 GLU A CA    1 
ATOM 2451 C C     . GLU A 1 587 ? 111.653 88.812  108.001 1.00 78.63  ? 581 GLU A C     1 
ATOM 2452 O O     . GLU A 1 587 ? 112.862 89.085  108.015 1.00 79.68  ? 581 GLU A O     1 
ATOM 2453 C CB    . GLU A 1 587 ? 111.724 86.362  107.529 1.00 77.92  ? 581 GLU A CB    1 
ATOM 2454 C CG    . GLU A 1 587 ? 111.226 86.479  106.104 1.00 76.58  ? 581 GLU A CG    1 
ATOM 2455 C CD    . GLU A 1 587 ? 112.177 85.844  105.110 1.00 81.76  ? 581 GLU A CD    1 
ATOM 2456 O OE1   . GLU A 1 587 ? 113.403 86.005  105.277 1.00 82.37  ? 581 GLU A OE1   1 
ATOM 2457 O OE2   . GLU A 1 587 ? 111.699 85.187  104.160 1.00 85.10  ? 581 GLU A OE2   1 
ATOM 2458 N N     . ARG A 1 588 ? 110.726 89.674  107.583 1.00 67.17  ? 582 ARG A N     1 
ATOM 2459 C CA    . ARG A 1 588 ? 111.085 91.053  107.281 1.00 67.27  ? 582 ARG A CA    1 
ATOM 2460 C C     . ARG A 1 588 ? 111.635 91.751  108.516 1.00 67.43  ? 582 ARG A C     1 
ATOM 2461 O O     . ARG A 1 588 ? 112.638 92.473  108.440 1.00 66.90  ? 582 ARG A O     1 
ATOM 2462 C CB    . ARG A 1 588 ? 109.867 91.792  106.735 1.00 65.95  ? 582 ARG A CB    1 
ATOM 2463 C CG    . ARG A 1 588 ? 109.988 93.298  106.741 1.00 66.20  ? 582 ARG A CG    1 
ATOM 2464 C CD    . ARG A 1 588 ? 108.614 93.946  106.687 1.00 69.05  ? 582 ARG A CD    1 
ATOM 2465 N NE    . ARG A 1 588 ? 107.846 93.577  105.500 1.00 69.04  ? 582 ARG A NE    1 
ATOM 2466 C CZ    . ARG A 1 588 ? 108.224 93.801  104.249 1.00 68.86  ? 582 ARG A CZ    1 
ATOM 2467 N NH1   . ARG A 1 588 ? 109.344 94.445  103.964 1.00 67.81  ? 582 ARG A NH1   1 
ATOM 2468 N NH2   . ARG A 1 588 ? 107.447 93.383  103.254 1.00 71.23  ? 582 ARG A NH2   1 
ATOM 2469 N N     . ARG A 1 589 ? 111.002 91.533  109.672 1.00 70.68  ? 583 ARG A N     1 
ATOM 2470 C CA    . ARG A 1 589 ? 111.514 92.101  110.912 1.00 66.12  ? 583 ARG A CA    1 
ATOM 2471 C C     . ARG A 1 589 ? 112.882 91.529  111.264 1.00 71.43  ? 583 ARG A C     1 
ATOM 2472 O O     . ARG A 1 589 ? 113.722 92.241  111.817 1.00 79.76  ? 583 ARG A O     1 
ATOM 2473 C CB    . ARG A 1 589 ? 110.517 91.875  112.053 1.00 67.19  ? 583 ARG A CB    1 
ATOM 2474 C CG    . ARG A 1 589 ? 110.686 90.566  112.809 1.00 67.35  ? 583 ARG A CG    1 
ATOM 2475 C CD    . ARG A 1 589 ? 109.505 90.289  113.728 1.00 71.33  ? 583 ARG A CD    1 
ATOM 2476 N NE    . ARG A 1 589 ? 109.185 91.431  114.577 1.00 78.06  ? 583 ARG A NE    1 
ATOM 2477 C CZ    . ARG A 1 589 ? 107.996 92.015  114.630 1.00 76.06  ? 583 ARG A CZ    1 
ATOM 2478 N NH1   . ARG A 1 589 ? 106.983 91.592  113.893 1.00 72.95  ? 583 ARG A NH1   1 
ATOM 2479 N NH2   . ARG A 1 589 ? 107.819 93.053  115.444 1.00 74.93  ? 583 ARG A NH2   1 
ATOM 2480 N N     . ARG A 1 590 ? 113.134 90.259  110.932 1.00 74.06  ? 584 ARG A N     1 
ATOM 2481 C CA    . ARG A 1 590 ? 114.441 89.673  111.214 1.00 70.20  ? 584 ARG A CA    1 
ATOM 2482 C C     . ARG A 1 590 ? 115.525 90.292  110.342 1.00 64.90  ? 584 ARG A C     1 
ATOM 2483 O O     . ARG A 1 590 ? 116.621 90.599  110.825 1.00 66.87  ? 584 ARG A O     1 
ATOM 2484 C CB    . ARG A 1 590 ? 114.391 88.159  111.016 1.00 69.09  ? 584 ARG A CB    1 
ATOM 2485 C CG    . ARG A 1 590 ? 113.434 87.450  111.955 1.00 68.52  ? 584 ARG A CG    1 
ATOM 2486 C CD    . ARG A 1 590 ? 113.584 85.945  111.863 1.00 70.17  ? 584 ARG A CD    1 
ATOM 2487 N NE    . ARG A 1 590 ? 112.394 85.316  111.302 1.00 71.48  ? 584 ARG A NE    1 
ATOM 2488 C CZ    . ARG A 1 590 ? 111.270 85.107  111.973 1.00 71.76  ? 584 ARG A CZ    1 
ATOM 2489 N NH1   . ARG A 1 590 ? 111.142 85.468  113.240 1.00 73.03  ? 584 ARG A NH1   1 
ATOM 2490 N NH2   . ARG A 1 590 ? 110.247 84.520  111.358 1.00 71.00  ? 584 ARG A NH2   1 
ATOM 2491 N N     . THR A 1 591 ? 115.235 90.482  109.054 1.00 57.53  ? 585 THR A N     1 
ATOM 2492 C CA    . THR A 1 591 ? 116.190 91.157  108.181 1.00 59.91  ? 585 THR A CA    1 
ATOM 2493 C C     . THR A 1 591 ? 116.437 92.586  108.645 1.00 62.82  ? 585 THR A C     1 
ATOM 2494 O O     . THR A 1 591 ? 117.578 93.068  108.630 1.00 63.60  ? 585 THR A O     1 
ATOM 2495 C CB    . THR A 1 591 ? 115.694 91.143  106.736 1.00 61.95  ? 585 THR A CB    1 
ATOM 2496 O OG1   . THR A 1 591 ? 114.385 91.722  106.673 1.00 63.54  ? 585 THR A OG1   1 
ATOM 2497 C CG2   . THR A 1 591 ? 115.640 89.719  106.207 1.00 62.44  ? 585 THR A CG2   1 
ATOM 2498 N N     . VAL A 1 592 ? 115.377 93.277  109.072 1.00 58.55  ? 586 VAL A N     1 
ATOM 2499 C CA    . VAL A 1 592 ? 115.529 94.642  109.574 1.00 58.03  ? 586 VAL A CA    1 
ATOM 2500 C C     . VAL A 1 592 ? 116.396 94.660  110.829 1.00 59.05  ? 586 VAL A C     1 
ATOM 2501 O O     . VAL A 1 592 ? 117.255 95.534  110.994 1.00 58.87  ? 586 VAL A O     1 
ATOM 2502 C CB    . VAL A 1 592 ? 114.149 95.270  109.828 1.00 50.79  ? 586 VAL A CB    1 
ATOM 2503 C CG1   . VAL A 1 592 ? 114.295 96.533  110.636 1.00 55.22  ? 586 VAL A CG1   1 
ATOM 2504 C CG2   . VAL A 1 592 ? 113.457 95.564  108.515 1.00 51.52  ? 586 VAL A CG2   1 
ATOM 2505 N N     . GLY A 1 593 ? 116.179 93.705  111.733 1.00 58.80  ? 587 GLY A N     1 
ATOM 2506 C CA    . GLY A 1 593 ? 116.992 93.639  112.936 1.00 54.30  ? 587 GLY A CA    1 
ATOM 2507 C C     . GLY A 1 593 ? 118.450 93.351  112.639 1.00 57.42  ? 587 GLY A C     1 
ATOM 2508 O O     . GLY A 1 593 ? 119.344 93.918  113.269 1.00 64.42  ? 587 GLY A O     1 
ATOM 2509 N N     . ARG A 1 594 ? 118.711 92.465  111.675 1.00 52.58  ? 588 ARG A N     1 
ATOM 2510 C CA    . ARG A 1 594 ? 120.089 92.211  111.266 1.00 51.79  ? 588 ARG A CA    1 
ATOM 2511 C C     . ARG A 1 594 ? 120.729 93.468  110.692 1.00 54.70  ? 588 ARG A C     1 
ATOM 2512 O O     . ARG A 1 594 ? 121.895 93.774  110.982 1.00 61.47  ? 588 ARG A O     1 
ATOM 2513 C CB    . ARG A 1 594 ? 120.133 91.074  110.246 1.00 56.56  ? 588 ARG A CB    1 
ATOM 2514 C CG    . ARG A 1 594 ? 121.334 90.159  110.392 1.00 56.25  ? 588 ARG A CG    1 
ATOM 2515 C CD    . ARG A 1 594 ? 121.371 89.123  109.284 1.00 55.92  ? 588 ARG A CD    1 
ATOM 2516 N NE    . ARG A 1 594 ? 120.076 88.482  109.088 1.00 60.56  ? 588 ARG A NE    1 
ATOM 2517 C CZ    . ARG A 1 594 ? 119.687 87.376  109.708 1.00 62.32  ? 588 ARG A CZ    1 
ATOM 2518 N NH1   . ARG A 1 594 ? 120.464 86.766  110.586 1.00 59.40  ? 588 ARG A NH1   1 
ATOM 2519 N NH2   . ARG A 1 594 ? 118.486 86.873  109.441 1.00 61.63  ? 588 ARG A NH2   1 
ATOM 2520 N N     . THR A 1 595 ? 119.980 94.212  109.876 1.00 45.78  ? 589 THR A N     1 
ATOM 2521 C CA    . THR A 1 595 ? 120.508 95.455  109.322 1.00 48.31  ? 589 THR A CA    1 
ATOM 2522 C C     . THR A 1 595 ? 120.798 96.473  110.418 1.00 54.90  ? 589 THR A C     1 
ATOM 2523 O O     . THR A 1 595 ? 121.815 97.172  110.371 1.00 56.47  ? 589 THR A O     1 
ATOM 2524 C CB    . THR A 1 595 ? 119.528 96.028  108.301 1.00 52.47  ? 589 THR A CB    1 
ATOM 2525 O OG1   . THR A 1 595 ? 119.074 94.980  107.438 1.00 56.58  ? 589 THR A OG1   1 
ATOM 2526 C CG2   . THR A 1 595 ? 120.203 97.106  107.468 1.00 51.10  ? 589 THR A CG2   1 
ATOM 2527 N N     . VAL A 1 596 ? 119.916 96.571  111.416 1.00 49.97  ? 590 VAL A N     1 
ATOM 2528 C CA    . VAL A 1 596 ? 120.134 97.516  112.508 1.00 38.53  ? 590 VAL A CA    1 
ATOM 2529 C C     . VAL A 1 596 ? 121.337 97.099  113.346 1.00 39.55  ? 590 VAL A C     1 
ATOM 2530 O O     . VAL A 1 596 ? 122.104 97.943  113.818 1.00 54.20  ? 590 VAL A O     1 
ATOM 2531 C CB    . VAL A 1 596 ? 118.860 97.655  113.362 1.00 33.67  ? 590 VAL A CB    1 
ATOM 2532 C CG1   . VAL A 1 596 ? 119.144 98.448  114.622 1.00 29.28  ? 590 VAL A CG1   1 
ATOM 2533 C CG2   . VAL A 1 596 ? 117.766 98.328  112.560 1.00 41.20  ? 590 VAL A CG2   1 
ATOM 2534 N N     . LYS A 1 597 ? 121.524 95.791  113.544 1.00 46.31  ? 591 LYS A N     1 
ATOM 2535 C CA    . LYS A 1 597 ? 122.711 95.315  114.247 1.00 49.76  ? 591 LYS A CA    1 
ATOM 2536 C C     . LYS A 1 597 ? 123.982 95.677  113.487 1.00 47.37  ? 591 LYS A C     1 
ATOM 2537 O O     . LYS A 1 597 ? 124.972 96.113  114.087 1.00 47.67  ? 591 LYS A O     1 
ATOM 2538 C CB    . LYS A 1 597 ? 122.623 93.804  114.458 1.00 50.39  ? 591 LYS A CB    1 
ATOM 2539 C CG    . LYS A 1 597 ? 123.953 93.139  114.755 1.00 48.57  ? 591 LYS A CG    1 
ATOM 2540 C CD    . LYS A 1 597 ? 123.763 91.714  115.238 1.00 52.82  ? 591 LYS A CD    1 
ATOM 2541 C CE    . LYS A 1 597 ? 123.279 90.818  114.114 1.00 51.36  ? 591 LYS A CE    1 
ATOM 2542 N NZ    . LYS A 1 597 ? 124.403 90.337  113.270 1.00 51.16  ? 591 LYS A NZ    1 
ATOM 2543 N N     . GLU A 1 598 ? 123.969 95.508  112.162 1.00 46.14  ? 592 GLU A N     1 
ATOM 2544 C CA    . GLU A 1 598 ? 125.121 95.907  111.359 1.00 49.72  ? 592 GLU A CA    1 
ATOM 2545 C C     . GLU A 1 598 ? 125.361 97.409  111.450 1.00 44.78  ? 592 GLU A C     1 
ATOM 2546 O O     . GLU A 1 598 ? 126.510 97.863  111.520 1.00 46.92  ? 592 GLU A O     1 
ATOM 2547 C CB    . GLU A 1 598 ? 124.916 95.486  109.904 1.00 45.51  ? 592 GLU A CB    1 
ATOM 2548 C CG    . GLU A 1 598 ? 125.199 94.020  109.634 1.00 48.99  ? 592 GLU A CG    1 
ATOM 2549 C CD    . GLU A 1 598 ? 124.869 93.618  108.211 1.00 56.87  ? 592 GLU A CD    1 
ATOM 2550 O OE1   . GLU A 1 598 ? 124.862 94.503  107.330 1.00 54.58  ? 592 GLU A OE1   1 
ATOM 2551 O OE2   . GLU A 1 598 ? 124.620 92.417  107.974 1.00 57.83  ? 592 GLU A OE2   1 
ATOM 2552 N N     . ILE A 1 599 ? 124.281 98.193  111.454 1.00 36.30  ? 593 ILE A N     1 
ATOM 2553 C CA    . ILE A 1 599 ? 124.399 99.644  111.565 1.00 40.83  ? 593 ILE A CA    1 
ATOM 2554 C C     . ILE A 1 599 ? 125.031 100.024 112.896 1.00 41.82  ? 593 ILE A C     1 
ATOM 2555 O O     . ILE A 1 599 ? 125.907 100.894 112.959 1.00 39.36  ? 593 ILE A O     1 
ATOM 2556 C CB    . ILE A 1 599 ? 123.019 100.302 111.381 1.00 33.23  ? 593 ILE A CB    1 
ATOM 2557 C CG1   . ILE A 1 599 ? 122.776 100.618 109.907 1.00 37.47  ? 593 ILE A CG1   1 
ATOM 2558 C CG2   . ILE A 1 599 ? 122.898 101.563 112.218 1.00 28.76  ? 593 ILE A CG2   1 
ATOM 2559 C CD1   . ILE A 1 599 ? 121.373 101.073 109.616 1.00 40.92  ? 593 ILE A CD1   1 
ATOM 2560 N N     . LYS A 1 600 ? 124.605 99.373  113.979 1.00 41.78  ? 594 LYS A N     1 
ATOM 2561 C CA    . LYS A 1 600 ? 125.167 99.675  115.291 1.00 28.32  ? 594 LYS A CA    1 
ATOM 2562 C C     . LYS A 1 600 ? 126.627 99.253  115.384 1.00 31.52  ? 594 LYS A C     1 
ATOM 2563 O O     . LYS A 1 600 ? 127.437 99.943  116.012 1.00 48.73  ? 594 LYS A O     1 
ATOM 2564 C CB    . LYS A 1 600 ? 124.342 99.006  116.385 1.00 32.89  ? 594 LYS A CB    1 
ATOM 2565 C CG    . LYS A 1 600 ? 123.303 99.920  117.000 1.00 35.68  ? 594 LYS A CG    1 
ATOM 2566 C CD    . LYS A 1 600 ? 123.951 100.919 117.938 1.00 39.67  ? 594 LYS A CD    1 
ATOM 2567 C CE    . LYS A 1 600 ? 124.787 100.222 118.995 1.00 39.06  ? 594 LYS A CE    1 
ATOM 2568 N NZ    . LYS A 1 600 ? 125.728 101.160 119.664 1.00 29.70  ? 594 LYS A NZ    1 
ATOM 2569 N N     . GLN A 1 601 ? 126.984 98.119  114.777 1.00 34.32  ? 595 GLN A N     1 
ATOM 2570 C CA    . GLN A 1 601 ? 128.387 97.710  114.769 1.00 41.24  ? 595 GLN A CA    1 
ATOM 2571 C C     . GLN A 1 601 ? 129.248 98.720  114.021 1.00 37.80  ? 595 GLN A C     1 
ATOM 2572 O O     . GLN A 1 601 ? 130.332 99.095  114.489 1.00 39.71  ? 595 GLN A O     1 
ATOM 2573 C CB    . GLN A 1 601 ? 128.528 96.321  114.150 1.00 39.81  ? 595 GLN A CB    1 
ATOM 2574 C CG    . GLN A 1 601 ? 128.183 95.182  115.090 1.00 39.15  ? 595 GLN A CG    1 
ATOM 2575 C CD    . GLN A 1 601 ? 128.282 93.829  114.419 1.00 45.35  ? 595 GLN A CD    1 
ATOM 2576 O OE1   . GLN A 1 601 ? 128.576 93.736  113.227 1.00 46.56  ? 595 GLN A OE1   1 
ATOM 2577 N NE2   . GLN A 1 601 ? 128.036 92.770  115.181 1.00 47.13  ? 595 GLN A NE2   1 
ATOM 2578 N N     . GLU A 1 602 ? 128.777 99.179  112.859 1.00 39.44  ? 596 GLU A N     1 
ATOM 2579 C CA    . GLU A 1 602 ? 129.517 100.192 112.114 1.00 34.94  ? 596 GLU A CA    1 
ATOM 2580 C C     . GLU A 1 602 ? 129.607 101.496 112.897 1.00 36.91  ? 596 GLU A C     1 
ATOM 2581 O O     . GLU A 1 602 ? 130.636 102.176 112.866 1.00 37.05  ? 596 GLU A O     1 
ATOM 2582 C CB    . GLU A 1 602 ? 128.864 100.426 110.752 1.00 34.10  ? 596 GLU A CB    1 
ATOM 2583 C CG    . GLU A 1 602 ? 129.410 101.626 109.999 1.00 39.04  ? 596 GLU A CG    1 
ATOM 2584 C CD    . GLU A 1 602 ? 130.769 101.359 109.387 1.00 47.88  ? 596 GLU A CD    1 
ATOM 2585 O OE1   . GLU A 1 602 ? 130.844 100.556 108.436 1.00 50.13  ? 596 GLU A OE1   1 
ATOM 2586 O OE2   . GLU A 1 602 ? 131.762 101.952 109.856 1.00 44.19  ? 596 GLU A OE2   1 
ATOM 2587 N N     . TYR A 1 603 ? 128.535 101.860 113.605 1.00 33.63  ? 597 TYR A N     1 
ATOM 2588 C CA    . TYR A 1 603 ? 128.555 103.069 114.421 1.00 22.57  ? 597 TYR A CA    1 
ATOM 2589 C C     . TYR A 1 603 ? 129.574 102.965 115.545 1.00 23.65  ? 597 TYR A C     1 
ATOM 2590 O O     . TYR A 1 603 ? 130.293 103.926 115.830 1.00 46.94  ? 597 TYR A O     1 
ATOM 2591 C CB    . TYR A 1 603 ? 127.160 103.339 114.982 1.00 28.82  ? 597 TYR A CB    1 
ATOM 2592 C CG    . TYR A 1 603 ? 127.127 104.314 116.132 1.00 31.27  ? 597 TYR A CG    1 
ATOM 2593 C CD1   . TYR A 1 603 ? 127.248 105.678 115.915 1.00 29.83  ? 597 TYR A CD1   1 
ATOM 2594 C CD2   . TYR A 1 603 ? 126.962 103.871 117.436 1.00 33.95  ? 597 TYR A CD2   1 
ATOM 2595 C CE1   . TYR A 1 603 ? 127.212 106.574 116.964 1.00 17.38  ? 597 TYR A CE1   1 
ATOM 2596 C CE2   . TYR A 1 603 ? 126.924 104.759 118.490 1.00 38.44  ? 597 TYR A CE2   1 
ATOM 2597 C CZ    . TYR A 1 603 ? 127.049 106.109 118.249 1.00 33.50  ? 597 TYR A CZ    1 
ATOM 2598 O OH    . TYR A 1 603 ? 127.011 106.997 119.297 1.00 42.77  ? 597 TYR A OH    1 
ATOM 2599 N N     . LYS A 1 604 ? 129.642 101.807 116.205 1.00 21.59  ? 598 LYS A N     1 
ATOM 2600 C CA    . LYS A 1 604 ? 130.637 101.614 117.254 1.00 27.56  ? 598 LYS A CA    1 
ATOM 2601 C C     . LYS A 1 604 ? 132.050 101.686 116.689 1.00 36.29  ? 598 LYS A C     1 
ATOM 2602 O O     . LYS A 1 604 ? 132.944 102.284 117.301 1.00 41.92  ? 598 LYS A O     1 
ATOM 2603 C CB    . LYS A 1 604 ? 130.409 100.279 117.961 1.00 30.30  ? 598 LYS A CB    1 
ATOM 2604 C CG    . LYS A 1 604 ? 129.382 100.337 119.077 1.00 38.47  ? 598 LYS A CG    1 
ATOM 2605 C CD    . LYS A 1 604 ? 129.048 98.952  119.607 1.00 34.78  ? 598 LYS A CD    1 
ATOM 2606 C CE    . LYS A 1 604 ? 130.274 98.054  119.638 1.00 38.52  ? 598 LYS A CE    1 
ATOM 2607 N NZ    . LYS A 1 604 ? 131.111 98.300  120.844 1.00 45.78  ? 598 LYS A NZ    1 
ATOM 2608 N N     . ARG A 1 605 ? 132.268 101.081 115.519 1.00 36.21  ? 599 ARG A N     1 
ATOM 2609 C CA    . ARG A 1 605 ? 133.580 101.161 114.881 1.00 27.77  ? 599 ARG A CA    1 
ATOM 2610 C C     . ARG A 1 605 ? 133.945 102.604 114.551 1.00 29.78  ? 599 ARG A C     1 
ATOM 2611 O O     . ARG A 1 605 ? 135.083 103.032 114.773 1.00 40.22  ? 599 ARG A O     1 
ATOM 2612 C CB    . ARG A 1 605 ? 133.596 100.300 113.620 1.00 32.27  ? 599 ARG A CB    1 
ATOM 2613 C CG    . ARG A 1 605 ? 134.966 99.773  113.242 1.00 35.11  ? 599 ARG A CG    1 
ATOM 2614 C CD    . ARG A 1 605 ? 135.005 99.343  111.784 1.00 40.97  ? 599 ARG A CD    1 
ATOM 2615 N NE    . ARG A 1 605 ? 134.944 100.480 110.874 1.00 41.35  ? 599 ARG A NE    1 
ATOM 2616 C CZ    . ARG A 1 605 ? 135.996 101.195 110.500 1.00 42.52  ? 599 ARG A CZ    1 
ATOM 2617 N NH1   . ARG A 1 605 ? 137.211 100.925 110.951 1.00 43.71  ? 599 ARG A NH1   1 
ATOM 2618 N NH2   . ARG A 1 605 ? 135.827 102.203 109.652 1.00 37.26  ? 599 ARG A NH2   1 
ATOM 2619 N N     . ILE A 1 606 ? 132.986 103.368 114.026 1.00 31.24  ? 600 ILE A N     1 
ATOM 2620 C CA    . ILE A 1 606 ? 133.234 104.764 113.676 1.00 27.79  ? 600 ILE A CA    1 
ATOM 2621 C C     . ILE A 1 606 ? 133.545 105.581 114.923 1.00 27.23  ? 600 ILE A C     1 
ATOM 2622 O O     . ILE A 1 606 ? 134.454 106.419 114.923 1.00 33.30  ? 600 ILE A O     1 
ATOM 2623 C CB    . ILE A 1 606 ? 132.031 105.336 112.905 1.00 31.22  ? 600 ILE A CB    1 
ATOM 2624 C CG1   . ILE A 1 606 ? 132.180 105.070 111.407 1.00 30.90  ? 600 ILE A CG1   1 
ATOM 2625 C CG2   . ILE A 1 606 ? 131.871 106.823 113.167 1.00 29.74  ? 600 ILE A CG2   1 
ATOM 2626 C CD1   . ILE A 1 606 ? 130.919 105.335 110.619 1.00 38.38  ? 600 ILE A CD1   1 
ATOM 2627 N N     . ARG A 1 607 ? 132.795 105.352 116.003 1.00 35.50  ? 601 ARG A N     1 
ATOM 2628 C CA    . ARG A 1 607 ? 133.038 106.083 117.242 1.00 23.56  ? 601 ARG A CA    1 
ATOM 2629 C C     . ARG A 1 607 ? 134.406 105.751 117.819 1.00 23.17  ? 601 ARG A C     1 
ATOM 2630 O O     . ARG A 1 607 ? 135.098 106.634 118.334 1.00 35.56  ? 601 ARG A O     1 
ATOM 2631 C CB    . ARG A 1 607 ? 131.939 105.775 118.256 1.00 29.11  ? 601 ARG A CB    1 
ATOM 2632 C CG    . ARG A 1 607 ? 131.766 106.837 119.324 1.00 27.14  ? 601 ARG A CG    1 
ATOM 2633 C CD    . ARG A 1 607 ? 130.963 106.305 120.493 1.00 34.30  ? 601 ARG A CD    1 
ATOM 2634 N NE    . ARG A 1 607 ? 131.199 104.884 120.716 1.00 19.30  ? 601 ARG A NE    1 
ATOM 2635 C CZ    . ARG A 1 607 ? 130.348 104.070 121.323 1.00 30.39  ? 601 ARG A CZ    1 
ATOM 2636 N NH1   . ARG A 1 607 ? 129.186 104.504 121.783 1.00 29.87  ? 601 ARG A NH1   1 
ATOM 2637 N NH2   . ARG A 1 607 ? 130.669 102.791 121.476 1.00 38.57  ? 601 ARG A NH2   1 
ATOM 2638 N N     . HIS A 1 608 ? 134.817 104.484 117.744 1.00 31.16  ? 602 HIS A N     1 
ATOM 2639 C CA    . HIS A 1 608 ? 136.146 104.122 118.225 1.00 32.80  ? 602 HIS A CA    1 
ATOM 2640 C C     . HIS A 1 608 ? 137.241 104.758 117.373 1.00 38.20  ? 602 HIS A C     1 
ATOM 2641 O O     . HIS A 1 608 ? 138.257 105.222 117.902 1.00 45.38  ? 602 HIS A O     1 
ATOM 2642 C CB    . HIS A 1 608 ? 136.306 102.606 118.257 1.00 21.94  ? 602 HIS A CB    1 
ATOM 2643 C CG    . HIS A 1 608 ? 137.491 102.146 119.045 1.00 31.63  ? 602 HIS A CG    1 
ATOM 2644 N ND1   . HIS A 1 608 ? 137.691 102.500 120.362 1.00 39.51  ? 602 HIS A ND1   1 
ATOM 2645 C CD2   . HIS A 1 608 ? 138.545 101.368 118.702 1.00 38.50  ? 602 HIS A CD2   1 
ATOM 2646 C CE1   . HIS A 1 608 ? 138.813 101.958 120.796 1.00 37.54  ? 602 HIS A CE1   1 
ATOM 2647 N NE2   . HIS A 1 608 ? 139.351 101.266 119.809 1.00 37.76  ? 602 HIS A NE2   1 
ATOM 2648 N N     . GLN A 1 609 ? 137.057 104.785 116.051 1.00 29.54  ? 603 GLN A N     1 
ATOM 2649 C CA    . GLN A 1 609 ? 138.042 105.436 115.190 1.00 22.51  ? 603 GLN A CA    1 
ATOM 2650 C C     . GLN A 1 609 ? 138.110 106.933 115.466 1.00 34.05  ? 603 GLN A C     1 
ATOM 2651 O O     . GLN A 1 609 ? 139.183 107.539 115.388 1.00 38.17  ? 603 GLN A O     1 
ATOM 2652 C CB    . GLN A 1 609 ? 137.716 105.174 113.721 1.00 26.82  ? 603 GLN A CB    1 
ATOM 2653 C CG    . GLN A 1 609 ? 137.807 103.715 113.317 1.00 35.32  ? 603 GLN A CG    1 
ATOM 2654 C CD    . GLN A 1 609 ? 139.114 103.076 113.731 1.00 39.05  ? 603 GLN A CD    1 
ATOM 2655 O OE1   . GLN A 1 609 ? 139.136 102.133 114.520 1.00 38.28  ? 603 GLN A OE1   1 
ATOM 2656 N NE2   . GLN A 1 609 ? 140.217 103.585 113.196 1.00 37.56  ? 603 GLN A NE2   1 
ATOM 2657 N N     . PHE A 1 610 ? 136.967 107.547 115.783 1.00 33.66  ? 604 PHE A N     1 
ATOM 2658 C CA    . PHE A 1 610 ? 136.952 108.960 116.147 1.00 19.87  ? 604 PHE A CA    1 
ATOM 2659 C C     . PHE A 1 610 ? 137.609 109.195 117.501 1.00 33.40  ? 604 PHE A C     1 
ATOM 2660 O O     . PHE A 1 610 ? 138.212 110.249 117.721 1.00 43.65  ? 604 PHE A O     1 
ATOM 2661 C CB    . PHE A 1 610 ? 135.516 109.480 116.154 1.00 16.81  ? 604 PHE A CB    1 
ATOM 2662 C CG    . PHE A 1 610 ? 135.411 110.976 116.155 1.00 25.65  ? 604 PHE A CG    1 
ATOM 2663 C CD1   . PHE A 1 610 ? 136.260 111.746 115.382 1.00 34.83  ? 604 PHE A CD1   1 
ATOM 2664 C CD2   . PHE A 1 610 ? 134.452 111.613 116.924 1.00 27.73  ? 604 PHE A CD2   1 
ATOM 2665 C CE1   . PHE A 1 610 ? 136.160 113.124 115.381 1.00 26.68  ? 604 PHE A CE1   1 
ATOM 2666 C CE2   . PHE A 1 610 ? 134.348 112.989 116.925 1.00 32.29  ? 604 PHE A CE2   1 
ATOM 2667 C CZ    . PHE A 1 610 ? 135.204 113.744 116.154 1.00 30.36  ? 604 PHE A CZ    1 
ATOM 2668 N N     . TYR A 1 611 ? 137.491 108.239 118.421 1.00 29.04  ? 605 TYR A N     1 
ATOM 2669 C CA    . TYR A 1 611 ? 138.167 108.350 119.707 1.00 19.56  ? 605 TYR A CA    1 
ATOM 2670 C C     . TYR A 1 611 ? 139.675 108.183 119.567 1.00 23.60  ? 605 TYR A C     1 
ATOM 2671 O O     . TYR A 1 611 ? 140.438 108.809 120.308 1.00 38.34  ? 605 TYR A O     1 
ATOM 2672 C CB    . TYR A 1 611 ? 137.585 107.320 120.678 1.00 31.14  ? 605 TYR A CB    1 
ATOM 2673 C CG    . TYR A 1 611 ? 138.508 106.840 121.781 1.00 28.10  ? 605 TYR A CG    1 
ATOM 2674 C CD1   . TYR A 1 611 ? 139.396 105.791 121.571 1.00 34.98  ? 605 TYR A CD1   1 
ATOM 2675 C CD2   . TYR A 1 611 ? 138.474 107.421 123.038 1.00 27.80  ? 605 TYR A CD2   1 
ATOM 2676 C CE1   . TYR A 1 611 ? 140.229 105.350 122.577 1.00 41.99  ? 605 TYR A CE1   1 
ATOM 2677 C CE2   . TYR A 1 611 ? 139.303 106.982 124.049 1.00 29.37  ? 605 TYR A CE2   1 
ATOM 2678 C CZ    . TYR A 1 611 ? 140.178 105.950 123.814 1.00 35.03  ? 605 TYR A CZ    1 
ATOM 2679 O OH    . TYR A 1 611 ? 141.004 105.516 124.823 1.00 37.61  ? 605 TYR A OH    1 
ATOM 2680 N N     . LEU A 1 612 ? 140.118 107.348 118.625 1.00 39.15  ? 606 LEU A N     1 
ATOM 2681 C CA    . LEU A 1 612 ? 141.536 107.026 118.502 1.00 42.50  ? 606 LEU A CA    1 
ATOM 2682 C C     . LEU A 1 612 ? 142.376 108.176 117.958 1.00 42.60  ? 606 LEU A C     1 
ATOM 2683 O O     . LEU A 1 612 ? 143.605 108.057 117.937 1.00 39.52  ? 606 LEU A O     1 
ATOM 2684 C CB    . LEU A 1 612 ? 141.722 105.795 117.615 1.00 31.25  ? 606 LEU A CB    1 
ATOM 2685 C CG    . LEU A 1 612 ? 141.433 104.445 118.274 1.00 29.89  ? 606 LEU A CG    1 
ATOM 2686 C CD1   . LEU A 1 612 ? 141.666 103.313 117.294 1.00 35.40  ? 606 LEU A CD1   1 
ATOM 2687 C CD2   . LEU A 1 612 ? 142.284 104.264 119.515 1.00 36.27  ? 606 LEU A CD2   1 
ATOM 2688 N N     . ARG A 1 613 ? 141.756 109.271 117.511 1.00 33.90  ? 607 ARG A N     1 
ATOM 2689 C CA    . ARG A 1 613 ? 142.525 110.411 117.022 1.00 31.40  ? 607 ARG A CA    1 
ATOM 2690 C C     . ARG A 1 613 ? 143.418 111.005 118.100 1.00 35.72  ? 607 ARG A C     1 
ATOM 2691 O O     . ARG A 1 613 ? 144.404 111.674 117.776 1.00 44.83  ? 607 ARG A O     1 
ATOM 2692 C CB    . ARG A 1 613 ? 141.586 111.491 116.490 1.00 31.22  ? 607 ARG A CB    1 
ATOM 2693 C CG    . ARG A 1 613 ? 140.691 112.076 117.559 1.00 26.13  ? 607 ARG A CG    1 
ATOM 2694 C CD    . ARG A 1 613 ? 139.611 112.962 116.986 1.00 21.79  ? 607 ARG A CD    1 
ATOM 2695 N NE    . ARG A 1 613 ? 138.455 112.990 117.870 1.00 23.55  ? 607 ARG A NE    1 
ATOM 2696 C CZ    . ARG A 1 613 ? 137.983 114.082 118.451 1.00 34.14  ? 607 ARG A CZ    1 
ATOM 2697 N NH1   . ARG A 1 613 ? 138.532 115.267 118.241 1.00 46.62  ? 607 ARG A NH1   1 
ATOM 2698 N NH2   . ARG A 1 613 ? 136.939 113.984 119.268 1.00 20.50  ? 607 ARG A NH2   1 
ATOM 2699 N N     . TYR A 1 614 ? 143.102 110.738 119.362 1.00 35.57  ? 608 TYR A N     1 
ATOM 2700 C CA    . TYR A 1 614 ? 143.885 111.289 120.459 1.00 32.53  ? 608 TYR A CA    1 
ATOM 2701 C C     . TYR A 1 614 ? 144.654 110.220 121.220 1.00 44.17  ? 608 TYR A C     1 
ATOM 2702 O O     . TYR A 1 614 ? 145.201 110.499 122.287 1.00 53.03  ? 608 TYR A O     1 
ATOM 2703 C CB    . TYR A 1 614 ? 142.967 112.028 121.434 1.00 28.86  ? 608 TYR A CB    1 
ATOM 2704 C CG    . TYR A 1 614 ? 142.614 113.433 121.010 1.00 29.13  ? 608 TYR A CG    1 
ATOM 2705 C CD1   . TYR A 1 614 ? 143.591 114.410 120.901 1.00 36.59  ? 608 TYR A CD1   1 
ATOM 2706 C CD2   . TYR A 1 614 ? 141.303 113.782 120.722 1.00 31.08  ? 608 TYR A CD2   1 
ATOM 2707 C CE1   . TYR A 1 614 ? 143.274 115.698 120.517 1.00 40.07  ? 608 TYR A CE1   1 
ATOM 2708 C CE2   . TYR A 1 614 ? 140.975 115.068 120.336 1.00 28.82  ? 608 TYR A CE2   1 
ATOM 2709 C CZ    . TYR A 1 614 ? 141.965 116.022 120.235 1.00 34.55  ? 608 TYR A CZ    1 
ATOM 2710 O OH    . TYR A 1 614 ? 141.643 117.303 119.851 1.00 41.58  ? 608 TYR A OH    1 
ATOM 2711 N N     . HIS A 1 615 ? 144.705 108.998 120.695 1.00 33.20  ? 609 HIS A N     1 
ATOM 2712 C CA    . HIS A 1 615 ? 145.349 107.930 121.449 1.00 39.75  ? 609 HIS A CA    1 
ATOM 2713 C C     . HIS A 1 615 ? 146.165 107.007 120.553 1.00 43.77  ? 609 HIS A C     1 
ATOM 2714 O O     . HIS A 1 615 ? 146.223 105.796 120.791 1.00 44.77  ? 609 HIS A O     1 
ATOM 2715 C CB    . HIS A 1 615 ? 144.315 107.131 122.239 1.00 46.76  ? 609 HIS A CB    1 
ATOM 2716 C CG    . HIS A 1 615 ? 143.607 107.941 123.278 1.00 49.31  ? 609 HIS A CG    1 
ATOM 2717 N ND1   . HIS A 1 615 ? 142.676 108.905 122.960 1.00 39.83  ? 609 HIS A ND1   1 
ATOM 2718 C CD2   . HIS A 1 615 ? 143.709 107.949 124.628 1.00 52.47  ? 609 HIS A CD2   1 
ATOM 2719 C CE1   . HIS A 1 615 ? 142.228 109.464 124.067 1.00 36.85  ? 609 HIS A CE1   1 
ATOM 2720 N NE2   . HIS A 1 615 ? 142.838 108.903 125.094 1.00 47.28  ? 609 HIS A NE2   1 
ATOM 2721 N N     . THR A 1 616 ? 146.801 107.563 119.528 1.00 53.30  ? 610 THR A N     1 
ATOM 2722 C CA    . THR A 1 616 ? 147.745 106.840 118.689 1.00 52.91  ? 610 THR A CA    1 
ATOM 2723 C C     . THR A 1 616 ? 148.889 107.791 118.361 1.00 55.40  ? 610 THR A C     1 
ATOM 2724 O O     . THR A 1 616 ? 149.060 108.831 119.004 1.00 57.02  ? 610 THR A O     1 
ATOM 2725 C CB    . THR A 1 616 ? 147.068 106.299 117.422 1.00 55.12  ? 610 THR A CB    1 
ATOM 2726 O OG1   . THR A 1 616 ? 146.125 107.258 116.931 1.00 58.29  ? 610 THR A OG1   1 
ATOM 2727 C CG2   . THR A 1 616 ? 146.354 104.988 117.708 1.00 48.28  ? 610 THR A CG2   1 
ATOM 2728 N N     . SER A 1 617 ? 149.684 107.435 117.353 1.00 67.20  ? 611 SER A N     1 
ATOM 2729 C CA    . SER A 1 617 ? 150.695 108.357 116.854 1.00 66.95  ? 611 SER A CA    1 
ATOM 2730 C C     . SER A 1 617 ? 150.080 109.556 116.147 1.00 67.95  ? 611 SER A C     1 
ATOM 2731 O O     . SER A 1 617 ? 150.802 110.509 115.836 1.00 71.40  ? 611 SER A O     1 
ATOM 2732 C CB    . SER A 1 617 ? 151.653 107.624 115.913 1.00 71.60  ? 611 SER A CB    1 
ATOM 2733 O OG    . SER A 1 617 ? 152.187 106.471 116.536 1.00 73.67  ? 611 SER A OG    1 
ATOM 2734 N N     . LYS A 1 618 ? 148.770 109.530 115.892 1.00 64.39  ? 612 LYS A N     1 
ATOM 2735 C CA    . LYS A 1 618 ? 147.983 110.605 115.288 1.00 66.27  ? 612 LYS A CA    1 
ATOM 2736 C C     . LYS A 1 618 ? 147.692 111.721 116.248 1.00 66.49  ? 612 LYS A C     1 
ATOM 2737 O O     . LYS A 1 618 ? 146.920 112.635 115.930 1.00 67.11  ? 612 LYS A O     1 
ATOM 2738 C CB    . LYS A 1 618 ? 146.679 110.030 114.731 1.00 62.31  ? 612 LYS A CB    1 
ATOM 2739 C CG    . LYS A 1 618 ? 146.120 110.790 113.537 1.00 64.13  ? 612 LYS A CG    1 
ATOM 2740 C CD    . LYS A 1 618 ? 145.124 109.953 112.745 1.00 67.58  ? 612 LYS A CD    1 
ATOM 2741 C CE    . LYS A 1 618 ? 145.581 108.508 112.605 1.00 69.18  ? 612 LYS A CE    1 
ATOM 2742 N NZ    . LYS A 1 618 ? 146.856 108.396 111.839 1.00 64.73  ? 612 LYS A NZ    1 
ATOM 2743 N N     . ARG A 1 619 ? 148.304 111.655 117.431 1.00 57.01  ? 613 ARG A N     1 
ATOM 2744 C CA    . ARG A 1 619 ? 148.124 112.712 118.414 1.00 57.54  ? 613 ARG A CA    1 
ATOM 2745 C C     . ARG A 1 619 ? 148.633 114.044 117.879 1.00 61.27  ? 613 ARG A C     1 
ATOM 2746 O O     . ARG A 1 619 ? 148.010 115.089 118.094 1.00 63.05  ? 613 ARG A O     1 
ATOM 2747 C CB    . ARG A 1 619 ? 148.845 112.344 119.708 1.00 58.98  ? 613 ARG A CB    1 
ATOM 2748 C CG    . ARG A 1 619 ? 147.959 111.704 120.755 1.00 50.51  ? 613 ARG A CG    1 
ATOM 2749 C CD    . ARG A 1 619 ? 148.653 111.699 122.096 1.00 53.57  ? 613 ARG A CD    1 
ATOM 2750 N NE    . ARG A 1 619 ? 149.758 110.750 122.138 1.00 54.72  ? 613 ARG A NE    1 
ATOM 2751 C CZ    . ARG A 1 619 ? 149.620 109.444 122.319 1.00 61.02  ? 613 ARG A CZ    1 
ATOM 2752 N NH1   . ARG A 1 619 ? 148.429 108.893 122.487 1.00 59.96  ? 613 ARG A NH1   1 
ATOM 2753 N NH2   . ARG A 1 619 ? 150.704 108.674 122.343 1.00 64.19  ? 613 ARG A NH2   1 
ATOM 2754 N N     . ASP A 1 620 ? 149.767 114.024 117.177 1.00 63.36  ? 614 ASP A N     1 
ATOM 2755 C CA    . ASP A 1 620 ? 150.343 115.270 116.687 1.00 66.47  ? 614 ASP A CA    1 
ATOM 2756 C C     . ASP A 1 620 ? 149.530 115.858 115.540 1.00 69.98  ? 614 ASP A C     1 
ATOM 2757 O O     . ASP A 1 620 ? 149.325 117.076 115.483 1.00 71.18  ? 614 ASP A O     1 
ATOM 2758 C CB    . ASP A 1 620 ? 151.789 115.049 116.253 1.00 68.90  ? 614 ASP A CB    1 
ATOM 2759 C CG    . ASP A 1 620 ? 152.475 116.340 115.863 1.00 75.37  ? 614 ASP A CG    1 
ATOM 2760 O OD1   . ASP A 1 620 ? 152.385 116.724 114.679 1.00 72.96  ? 614 ASP A OD1   1 
ATOM 2761 O OD2   . ASP A 1 620 ? 153.095 116.976 116.741 1.00 76.37  ? 614 ASP A OD2   1 
ATOM 2762 N N     . ARG A 1 621 ? 149.058 115.019 114.620 1.00 62.94  ? 615 ARG A N     1 
ATOM 2763 C CA    . ARG A 1 621 ? 148.369 115.507 113.431 1.00 61.50  ? 615 ARG A CA    1 
ATOM 2764 C C     . ARG A 1 621 ? 146.870 115.702 113.627 1.00 57.50  ? 615 ARG A C     1 
ATOM 2765 O O     . ARG A 1 621 ? 146.176 116.028 112.659 1.00 58.99  ? 615 ARG A O     1 
ATOM 2766 C CB    . ARG A 1 621 ? 148.619 114.578 112.233 1.00 62.22  ? 615 ARG A CB    1 
ATOM 2767 C CG    . ARG A 1 621 ? 150.011 113.961 112.149 1.00 63.48  ? 615 ARG A CG    1 
ATOM 2768 C CD    . ARG A 1 621 ? 150.031 112.740 111.228 1.00 64.11  ? 615 ARG A CD    1 
ATOM 2769 N NE    . ARG A 1 621 ? 149.532 111.507 111.827 1.00 69.05  ? 615 ARG A NE    1 
ATOM 2770 C CZ    . ARG A 1 621 ? 150.295 110.641 112.480 1.00 68.59  ? 615 ARG A CZ    1 
ATOM 2771 N NH1   . ARG A 1 621 ? 151.588 110.858 112.658 1.00 66.76  ? 615 ARG A NH1   1 
ATOM 2772 N NH2   . ARG A 1 621 ? 149.755 109.520 112.947 1.00 61.48  ? 615 ARG A NH2   1 
ATOM 2773 N N     . THR A 1 622 ? 146.352 115.510 114.836 1.00 46.23  ? 616 THR A N     1 
ATOM 2774 C CA    . THR A 1 622 ? 144.954 115.830 115.099 1.00 42.31  ? 616 THR A CA    1 
ATOM 2775 C C     . THR A 1 622 ? 144.779 117.339 115.220 1.00 42.97  ? 616 THR A C     1 
ATOM 2776 O O     . THR A 1 622 ? 145.524 118.007 115.942 1.00 46.62  ? 616 THR A O     1 
ATOM 2777 C CB    . THR A 1 622 ? 144.480 115.133 116.374 1.00 43.99  ? 616 THR A CB    1 
ATOM 2778 O OG1   . THR A 1 622 ? 144.640 113.716 116.233 1.00 46.44  ? 616 THR A OG1   1 
ATOM 2779 C CG2   . THR A 1 622 ? 143.018 115.443 116.642 1.00 44.53  ? 616 THR A CG2   1 
ATOM 2780 N N     . GLU A 1 623 ? 143.795 117.879 114.505 1.00 39.67  ? 617 GLU A N     1 
ATOM 2781 C CA    . GLU A 1 623 ? 143.539 119.310 114.518 1.00 34.68  ? 617 GLU A CA    1 
ATOM 2782 C C     . GLU A 1 623 ? 142.682 119.698 115.720 1.00 37.36  ? 617 GLU A C     1 
ATOM 2783 O O     . GLU A 1 623 ? 142.012 118.866 116.338 1.00 41.19  ? 617 GLU A O     1 
ATOM 2784 C CB    . GLU A 1 623 ? 142.848 119.743 113.228 1.00 39.03  ? 617 GLU A CB    1 
ATOM 2785 C CG    . GLU A 1 623 ? 143.792 120.245 112.150 1.00 41.44  ? 617 GLU A CG    1 
ATOM 2786 C CD    . GLU A 1 623 ? 143.073 121.039 111.079 1.00 45.57  ? 617 GLU A CD    1 
ATOM 2787 O OE1   . GLU A 1 623 ? 142.288 121.942 111.436 1.00 45.08  ? 617 GLU A OE1   1 
ATOM 2788 O OE2   . GLU A 1 623 ? 143.288 120.758 109.883 1.00 42.24  ? 617 GLU A OE2   1 
ATOM 2789 N N     . LEU A 1 624 ? 142.715 120.992 116.047 1.00 33.10  ? 618 LEU A N     1 
ATOM 2790 C CA    . LEU A 1 624 ? 141.885 121.507 117.132 1.00 34.14  ? 618 LEU A CA    1 
ATOM 2791 C C     . LEU A 1 624 ? 140.407 121.327 116.817 1.00 31.52  ? 618 LEU A C     1 
ATOM 2792 O O     . LEU A 1 624 ? 139.623 120.903 117.672 1.00 40.15  ? 618 LEU A O     1 
ATOM 2793 C CB    . LEU A 1 624 ? 142.209 122.980 117.381 1.00 21.48  ? 618 LEU A CB    1 
ATOM 2794 C CG    . LEU A 1 624 ? 142.114 123.508 118.812 1.00 22.33  ? 618 LEU A CG    1 
ATOM 2795 C CD1   . LEU A 1 624 ? 142.910 124.792 118.941 1.00 33.63  ? 618 LEU A CD1   1 
ATOM 2796 C CD2   . LEU A 1 624 ? 140.672 123.740 119.215 1.00 26.29  ? 618 LEU A CD2   1 
ATOM 2797 N N     . ILE A 1 625 ? 140.009 121.647 115.591 1.00 18.35  ? 619 ILE A N     1 
ATOM 2798 C CA    . ILE A 1 625 ? 138.644 121.460 115.127 1.00 13.84  ? 619 ILE A CA    1 
ATOM 2799 C C     . ILE A 1 625 ? 138.704 120.908 113.712 1.00 31.41  ? 619 ILE A C     1 
ATOM 2800 O O     . ILE A 1 625 ? 139.613 121.225 112.940 1.00 36.77  ? 619 ILE A O     1 
ATOM 2801 C CB    . ILE A 1 625 ? 137.828 122.774 115.188 1.00 14.72  ? 619 ILE A CB    1 
ATOM 2802 C CG1   . ILE A 1 625 ? 136.350 122.515 114.895 1.00 10.17  ? 619 ILE A CG1   1 
ATOM 2803 C CG2   . ILE A 1 625 ? 138.402 123.818 114.241 1.00 24.40  ? 619 ILE A CG2   1 
ATOM 2804 C CD1   . ILE A 1 625 ? 135.511 122.323 116.128 1.00 20.10  ? 619 ILE A CD1   1 
ATOM 2805 N N     . SER A 1 626 ? 137.741 120.053 113.378 1.00 33.02  ? 620 SER A N     1 
ATOM 2806 C CA    . SER A 1 626 ? 137.721 119.415 112.073 1.00 22.42  ? 620 SER A CA    1 
ATOM 2807 C C     . SER A 1 626 ? 136.277 119.224 111.635 1.00 19.81  ? 620 SER A C     1 
ATOM 2808 O O     . SER A 1 626 ? 135.339 119.403 112.415 1.00 25.92  ? 620 SER A O     1 
ATOM 2809 C CB    . SER A 1 626 ? 138.474 118.082 112.091 1.00 23.94  ? 620 SER A CB    1 
ATOM 2810 O OG    . SER A 1 626 ? 137.881 117.171 112.996 1.00 28.60  ? 620 SER A OG    1 
ATOM 2811 N N     . ALA A 1 627 ? 136.110 118.863 110.362 1.00 36.79  ? 621 ALA A N     1 
ATOM 2812 C CA    . ALA A 1 627 ? 134.784 118.687 109.786 1.00 41.89  ? 621 ALA A CA    1 
ATOM 2813 C C     . ALA A 1 627 ? 134.043 117.485 110.352 1.00 43.20  ? 621 ALA A C     1 
ATOM 2814 O O     . ALA A 1 627 ? 132.825 117.390 110.165 1.00 42.03  ? 621 ALA A O     1 
ATOM 2815 C CB    . ALA A 1 627 ? 134.888 118.560 108.267 1.00 35.86  ? 621 ALA A CB    1 
ATOM 2816 N N     . GLU A 1 628 ? 134.737 116.571 111.031 1.00 34.60  ? 622 GLU A N     1 
ATOM 2817 C CA    . GLU A 1 628 ? 134.077 115.407 111.605 1.00 21.91  ? 622 GLU A CA    1 
ATOM 2818 C C     . GLU A 1 628 ? 133.294 115.731 112.867 1.00 24.05  ? 622 GLU A C     1 
ATOM 2819 O O     . GLU A 1 628 ? 132.413 114.954 113.244 1.00 41.44  ? 622 GLU A O     1 
ATOM 2820 C CB    . GLU A 1 628 ? 135.102 114.314 111.907 1.00 24.62  ? 622 GLU A CB    1 
ATOM 2821 C CG    . GLU A 1 628 ? 135.690 113.667 110.671 1.00 36.39  ? 622 GLU A CG    1 
ATOM 2822 C CD    . GLU A 1 628 ? 137.004 114.290 110.267 1.00 42.15  ? 622 GLU A CD    1 
ATOM 2823 O OE1   . GLU A 1 628 ? 137.336 115.367 110.801 1.00 53.07  ? 622 GLU A OE1   1 
ATOM 2824 O OE2   . GLU A 1 628 ? 137.709 113.706 109.417 1.00 41.54  ? 622 GLU A OE2   1 
ATOM 2825 N N     . TYR A 1 629 ? 133.584 116.856 113.525 1.00 11.28  ? 623 TYR A N     1 
ATOM 2826 C CA    . TYR A 1 629 ? 132.830 117.232 114.715 1.00 14.72  ? 623 TYR A CA    1 
ATOM 2827 C C     . TYR A 1 629 ? 131.362 117.489 114.408 1.00 32.75  ? 623 TYR A C     1 
ATOM 2828 O O     . TYR A 1 629 ? 130.518 117.339 115.297 1.00 38.50  ? 623 TYR A O     1 
ATOM 2829 C CB    . TYR A 1 629 ? 133.435 118.479 115.358 1.00 22.68  ? 623 TYR A CB    1 
ATOM 2830 C CG    . TYR A 1 629 ? 134.743 118.254 116.076 1.00 18.33  ? 623 TYR A CG    1 
ATOM 2831 C CD1   . TYR A 1 629 ? 135.894 117.927 115.379 1.00 25.95  ? 623 TYR A CD1   1 
ATOM 2832 C CD2   . TYR A 1 629 ? 134.829 118.384 117.454 1.00 17.55  ? 623 TYR A CD2   1 
ATOM 2833 C CE1   . TYR A 1 629 ? 137.087 117.728 116.030 1.00 23.54  ? 623 TYR A CE1   1 
ATOM 2834 C CE2   . TYR A 1 629 ? 136.017 118.187 118.113 1.00 25.25  ? 623 TYR A CE2   1 
ATOM 2835 C CZ    . TYR A 1 629 ? 137.144 117.861 117.396 1.00 31.46  ? 623 TYR A CZ    1 
ATOM 2836 O OH    . TYR A 1 629 ? 138.337 117.660 118.048 1.00 30.30  ? 623 TYR A OH    1 
ATOM 2837 N N     . PHE A 1 630 ? 131.041 117.881 113.177 1.00 30.58  ? 624 PHE A N     1 
ATOM 2838 C CA    . PHE A 1 630 ? 129.670 118.129 112.751 1.00 22.62  ? 624 PHE A CA    1 
ATOM 2839 C C     . PHE A 1 630 ? 129.040 116.914 112.088 1.00 29.65  ? 624 PHE A C     1 
ATOM 2840 O O     . PHE A 1 630 ? 127.850 116.638 112.295 1.00 41.25  ? 624 PHE A O     1 
ATOM 2841 C CB    . PHE A 1 630 ? 129.633 119.319 111.786 1.00 32.95  ? 624 PHE A CB    1 
ATOM 2842 C CG    . PHE A 1 630 ? 130.505 120.472 112.208 1.00 33.68  ? 624 PHE A CG    1 
ATOM 2843 C CD1   . PHE A 1 630 ? 130.019 121.451 113.057 1.00 33.55  ? 624 PHE A CD1   1 
ATOM 2844 C CD2   . PHE A 1 630 ? 131.807 120.577 111.751 1.00 26.16  ? 624 PHE A CD2   1 
ATOM 2845 C CE1   . PHE A 1 630 ? 130.818 122.509 113.443 1.00 23.01  ? 624 PHE A CE1   1 
ATOM 2846 C CE2   . PHE A 1 630 ? 132.607 121.634 112.136 1.00 22.87  ? 624 PHE A CE2   1 
ATOM 2847 C CZ    . PHE A 1 630 ? 132.112 122.597 112.981 1.00 20.93  ? 624 PHE A CZ    1 
ATOM 2848 N N     . ARG A 1 631 ? 129.820 116.174 111.299 1.00 30.52  ? 625 ARG A N     1 
ATOM 2849 C CA    . ARG A 1 631 ? 129.322 114.936 110.716 1.00 33.40  ? 625 ARG A CA    1 
ATOM 2850 C C     . ARG A 1 631 ? 128.969 113.928 111.798 1.00 36.97  ? 625 ARG A C     1 
ATOM 2851 O O     . ARG A 1 631 ? 127.985 113.191 111.673 1.00 35.76  ? 625 ARG A O     1 
ATOM 2852 C CB    . ARG A 1 631 ? 130.359 114.352 109.760 1.00 28.63  ? 625 ARG A CB    1 
ATOM 2853 C CG    . ARG A 1 631 ? 130.339 114.975 108.385 1.00 30.93  ? 625 ARG A CG    1 
ATOM 2854 C CD    . ARG A 1 631 ? 129.428 114.211 107.449 1.00 36.01  ? 625 ARG A CD    1 
ATOM 2855 N NE    . ARG A 1 631 ? 128.049 114.677 107.522 1.00 34.44  ? 625 ARG A NE    1 
ATOM 2856 C CZ    . ARG A 1 631 ? 127.598 115.771 106.927 1.00 34.96  ? 625 ARG A CZ    1 
ATOM 2857 N NH1   . ARG A 1 631 ? 128.392 116.545 106.206 1.00 40.61  ? 625 ARG A NH1   1 
ATOM 2858 N NH2   . ARG A 1 631 ? 126.314 116.096 107.055 1.00 32.12  ? 625 ARG A NH2   1 
ATOM 2859 N N     . MET A 1 632 ? 129.762 113.880 112.870 1.00 36.08  ? 626 MET A N     1 
ATOM 2860 C CA    . MET A 1 632 ? 129.448 112.988 113.978 1.00 32.01  ? 626 MET A CA    1 
ATOM 2861 C C     . MET A 1 632 ? 128.150 113.394 114.661 1.00 31.96  ? 626 MET A C     1 
ATOM 2862 O O     . MET A 1 632 ? 127.367 112.533 115.065 1.00 44.53  ? 626 MET A O     1 
ATOM 2863 C CB    . MET A 1 632 ? 130.602 112.963 114.977 1.00 26.75  ? 626 MET A CB    1 
ATOM 2864 C CG    . MET A 1 632 ? 130.490 111.864 116.019 1.00 29.80  ? 626 MET A CG    1 
ATOM 2865 S SD    . MET A 1 632 ? 130.889 110.237 115.360 1.00 48.96  ? 626 MET A SD    1 
ATOM 2866 C CE    . MET A 1 632 ? 129.692 109.225 116.220 1.00 41.43  ? 626 MET A CE    1 
ATOM 2867 N N     . LEU A 1 633 ? 127.902 114.698 114.800 1.00 13.39  ? 627 LEU A N     1 
ATOM 2868 C CA    . LEU A 1 633 ? 126.644 115.147 115.388 1.00 13.46  ? 627 LEU A CA    1 
ATOM 2869 C C     . LEU A 1 633 ? 125.457 114.766 114.513 1.00 30.13  ? 627 LEU A C     1 
ATOM 2870 O O     . LEU A 1 633 ? 124.425 114.300 115.018 1.00 43.98  ? 627 LEU A O     1 
ATOM 2871 C CB    . LEU A 1 633 ? 126.680 116.657 115.612 1.00 22.46  ? 627 LEU A CB    1 
ATOM 2872 C CG    . LEU A 1 633 ? 127.612 117.162 116.711 1.00 31.80  ? 627 LEU A CG    1 
ATOM 2873 C CD1   . LEU A 1 633 ? 127.717 118.671 116.667 1.00 30.78  ? 627 LEU A CD1   1 
ATOM 2874 C CD2   . LEU A 1 633 ? 127.124 116.702 118.067 1.00 33.04  ? 627 LEU A CD2   1 
ATOM 2875 N N     . PHE A 1 634 ? 125.583 114.956 113.199 1.00 34.97  ? 628 PHE A N     1 
ATOM 2876 C CA    . PHE A 1 634 ? 124.503 114.565 112.297 1.00 27.15  ? 628 PHE A CA    1 
ATOM 2877 C C     . PHE A 1 634 ? 124.266 113.059 112.341 1.00 33.67  ? 628 PHE A C     1 
ATOM 2878 O O     . PHE A 1 634 ? 123.116 112.604 112.351 1.00 34.92  ? 628 PHE A O     1 
ATOM 2879 C CB    . PHE A 1 634 ? 124.814 115.018 110.872 1.00 33.21  ? 628 PHE A CB    1 
ATOM 2880 C CG    . PHE A 1 634 ? 124.838 116.508 110.703 1.00 37.29  ? 628 PHE A CG    1 
ATOM 2881 C CD1   . PHE A 1 634 ? 123.800 117.288 111.181 1.00 35.12  ? 628 PHE A CD1   1 
ATOM 2882 C CD2   . PHE A 1 634 ? 125.891 117.128 110.057 1.00 27.37  ? 628 PHE A CD2   1 
ATOM 2883 C CE1   . PHE A 1 634 ? 123.819 118.658 111.025 1.00 35.52  ? 628 PHE A CE1   1 
ATOM 2884 C CE2   . PHE A 1 634 ? 125.915 118.497 109.901 1.00 26.94  ? 628 PHE A CE2   1 
ATOM 2885 C CZ    . PHE A 1 634 ? 124.877 119.261 110.383 1.00 37.96  ? 628 PHE A CZ    1 
ATOM 2886 N N     . LEU A 1 635 ? 125.345 112.273 112.370 1.00 34.61  ? 629 LEU A N     1 
ATOM 2887 C CA    . LEU A 1 635 ? 125.211 110.824 112.463 1.00 19.86  ? 629 LEU A CA    1 
ATOM 2888 C C     . LEU A 1 635 ? 124.557 110.415 113.775 1.00 20.58  ? 629 LEU A C     1 
ATOM 2889 O O     . LEU A 1 635 ? 123.739 109.493 113.804 1.00 30.15  ? 629 LEU A O     1 
ATOM 2890 C CB    . LEU A 1 635 ? 126.581 110.162 112.317 1.00 20.78  ? 629 LEU A CB    1 
ATOM 2891 C CG    . LEU A 1 635 ? 126.749 108.712 112.776 1.00 13.47  ? 629 LEU A CG    1 
ATOM 2892 C CD1   . LEU A 1 635 ? 125.788 107.783 112.054 1.00 20.87  ? 629 LEU A CD1   1 
ATOM 2893 C CD2   . LEU A 1 635 ? 128.183 108.258 112.576 1.00 15.22  ? 629 LEU A CD2   1 
ATOM 2894 N N     . VAL A 1 636 ? 124.914 111.084 114.873 1.00 26.45  ? 630 VAL A N     1 
ATOM 2895 C CA    . VAL A 1 636 ? 124.308 110.770 116.163 1.00 26.66  ? 630 VAL A CA    1 
ATOM 2896 C C     . VAL A 1 636 ? 122.815 111.054 116.128 1.00 32.76  ? 630 VAL A C     1 
ATOM 2897 O O     . VAL A 1 636 ? 122.008 110.255 116.614 1.00 45.56  ? 630 VAL A O     1 
ATOM 2898 C CB    . VAL A 1 636 ? 125.008 111.551 117.291 1.00 27.06  ? 630 VAL A CB    1 
ATOM 2899 C CG1   . VAL A 1 636 ? 124.147 111.570 118.539 1.00 20.88  ? 630 VAL A CG1   1 
ATOM 2900 C CG2   . VAL A 1 636 ? 126.357 110.934 117.597 1.00 28.36  ? 630 VAL A CG2   1 
ATOM 2901 N N     . LYS A 1 637 ? 122.418 112.188 115.547 1.00 17.81  ? 631 LYS A N     1 
ATOM 2902 C CA    . LYS A 1 637 ? 120.992 112.497 115.452 1.00 21.34  ? 631 LYS A CA    1 
ATOM 2903 C C     . LYS A 1 637 ? 120.256 111.476 114.589 1.00 35.36  ? 631 LYS A C     1 
ATOM 2904 O O     . LYS A 1 637 ? 119.172 110.999 114.958 1.00 50.92  ? 631 LYS A O     1 
ATOM 2905 C CB    . LYS A 1 637 ? 120.797 113.907 114.902 1.00 35.04  ? 631 LYS A CB    1 
ATOM 2906 C CG    . LYS A 1 637 ? 119.463 114.531 115.271 1.00 34.08  ? 631 LYS A CG    1 
ATOM 2907 C CD    . LYS A 1 637 ? 119.612 116.010 115.599 1.00 38.71  ? 631 LYS A CD    1 
ATOM 2908 C CE    . LYS A 1 637 ? 120.567 116.704 114.641 1.00 39.60  ? 631 LYS A CE    1 
ATOM 2909 N NZ    . LYS A 1 637 ? 120.049 116.706 113.248 1.00 46.24  ? 631 LYS A NZ    1 
ATOM 2910 N N     . ASN A 1 638 ? 120.834 111.121 113.437 1.00 32.99  ? 632 ASN A N     1 
ATOM 2911 C CA    . ASN A 1 638 ? 120.181 110.166 112.547 1.00 26.98  ? 632 ASN A CA    1 
ATOM 2912 C C     . ASN A 1 638 ? 120.076 108.787 113.188 1.00 28.69  ? 632 ASN A C     1 
ATOM 2913 O O     . ASN A 1 638 ? 119.046 108.115 113.065 1.00 27.83  ? 632 ASN A O     1 
ATOM 2914 C CB    . ASN A 1 638 ? 120.936 110.089 111.222 1.00 26.90  ? 632 ASN A CB    1 
ATOM 2915 C CG    . ASN A 1 638 ? 120.587 111.228 110.288 1.00 31.46  ? 632 ASN A CG    1 
ATOM 2916 O OD1   . ASN A 1 638 ? 121.042 111.271 109.146 1.00 27.81  ? 632 ASN A OD1   1 
ATOM 2917 N ND2   . ASN A 1 638 ? 119.774 112.159 110.767 1.00 33.58  ? 632 ASN A ND2   1 
ATOM 2918 N N     . LEU A 1 639 ? 121.129 108.349 113.881 1.00 33.77  ? 633 LEU A N     1 
ATOM 2919 C CA    . LEU A 1 639 ? 121.087 107.060 114.560 1.00 27.14  ? 633 LEU A CA    1 
ATOM 2920 C C     . LEU A 1 639 ? 120.124 107.081 115.737 1.00 27.49  ? 633 LEU A C     1 
ATOM 2921 O O     . LEU A 1 639 ? 119.477 106.070 116.016 1.00 43.77  ? 633 LEU A O     1 
ATOM 2922 C CB    . LEU A 1 639 ? 122.485 106.665 115.027 1.00 20.55  ? 633 LEU A CB    1 
ATOM 2923 C CG    . LEU A 1 639 ? 122.578 105.350 115.794 1.00 22.30  ? 633 LEU A CG    1 
ATOM 2924 C CD1   . LEU A 1 639 ? 122.531 104.172 114.842 1.00 30.48  ? 633 LEU A CD1   1 
ATOM 2925 C CD2   . LEU A 1 639 ? 123.839 105.320 116.620 1.00 25.96  ? 633 LEU A CD2   1 
ATOM 2926 N N     . ARG A 1 640 ? 120.016 108.211 116.436 1.00 21.75  ? 634 ARG A N     1 
ATOM 2927 C CA    . ARG A 1 640 ? 119.017 108.338 117.487 1.00 31.63  ? 634 ARG A CA    1 
ATOM 2928 C C     . ARG A 1 640 ? 117.622 108.151 116.917 1.00 37.06  ? 634 ARG A C     1 
ATOM 2929 O O     . ARG A 1 640 ? 116.796 107.426 117.483 1.00 53.98  ? 634 ARG A O     1 
ATOM 2930 C CB    . ARG A 1 640 ? 119.135 109.704 118.162 1.00 33.90  ? 634 ARG A CB    1 
ATOM 2931 C CG    . ARG A 1 640 ? 120.012 109.727 119.388 1.00 36.58  ? 634 ARG A CG    1 
ATOM 2932 C CD    . ARG A 1 640 ? 119.302 110.391 120.552 1.00 42.85  ? 634 ARG A CD    1 
ATOM 2933 N NE    . ARG A 1 640 ? 118.612 111.612 120.155 1.00 35.71  ? 634 ARG A NE    1 
ATOM 2934 C CZ    . ARG A 1 640 ? 119.190 112.801 120.057 1.00 35.14  ? 634 ARG A CZ    1 
ATOM 2935 N NH1   . ARG A 1 640 ? 120.478 112.967 120.308 1.00 36.86  ? 634 ARG A NH1   1 
ATOM 2936 N NH2   . ARG A 1 640 ? 118.457 113.850 119.699 1.00 40.58  ? 634 ARG A NH2   1 
ATOM 2937 N N     . ASN A 1 641 ? 117.347 108.790 115.778 1.00 35.58  ? 635 ASN A N     1 
ATOM 2938 C CA    . ASN A 1 641 ? 116.044 108.631 115.141 1.00 42.71  ? 635 ASN A CA    1 
ATOM 2939 C C     . ASN A 1 641 ? 115.809 107.187 114.710 1.00 43.29  ? 635 ASN A C     1 
ATOM 2940 O O     . ASN A 1 641 ? 114.720 106.637 114.918 1.00 38.30  ? 635 ASN A O     1 
ATOM 2941 C CB    . ASN A 1 641 ? 115.932 109.577 113.949 1.00 46.58  ? 635 ASN A CB    1 
ATOM 2942 C CG    . ASN A 1 641 ? 116.024 111.032 114.354 1.00 53.33  ? 635 ASN A CG    1 
ATOM 2943 O OD1   . ASN A 1 641 ? 115.140 111.554 115.032 1.00 57.58  ? 635 ASN A OD1   1 
ATOM 2944 N ND2   . ASN A 1 641 ? 117.097 111.695 113.944 1.00 52.30  ? 635 ASN A ND2   1 
ATOM 2945 N N     . LEU A 1 642 ? 116.823 106.552 114.116 1.00 42.29  ? 636 LEU A N     1 
ATOM 2946 C CA    . LEU A 1 642 ? 116.671 105.174 113.658 1.00 29.02  ? 636 LEU A CA    1 
ATOM 2947 C C     . LEU A 1 642 ? 116.416 104.222 114.820 1.00 37.29  ? 636 LEU A C     1 
ATOM 2948 O O     . LEU A 1 642 ? 115.560 103.334 114.728 1.00 46.83  ? 636 LEU A O     1 
ATOM 2949 C CB    . LEU A 1 642 ? 117.908 104.740 112.876 1.00 33.59  ? 636 LEU A CB    1 
ATOM 2950 C CG    . LEU A 1 642 ? 118.018 103.240 112.599 1.00 31.17  ? 636 LEU A CG    1 
ATOM 2951 C CD1   . LEU A 1 642 ? 116.928 102.799 111.643 1.00 35.85  ? 636 LEU A CD1   1 
ATOM 2952 C CD2   . LEU A 1 642 ? 119.385 102.900 112.042 1.00 36.91  ? 636 LEU A CD2   1 
ATOM 2953 N N     . LEU A 1 643 ? 117.152 104.385 115.920 1.00 45.26  ? 637 LEU A N     1 
ATOM 2954 C CA    . LEU A 1 643 ? 116.967 103.506 117.069 1.00 37.35  ? 637 LEU A CA    1 
ATOM 2955 C C     . LEU A 1 643 ? 115.629 103.759 117.748 1.00 42.16  ? 637 LEU A C     1 
ATOM 2956 O O     . LEU A 1 643 ? 114.978 102.817 118.211 1.00 47.39  ? 637 LEU A O     1 
ATOM 2957 C CB    . LEU A 1 643 ? 118.115 103.685 118.059 1.00 34.73  ? 637 LEU A CB    1 
ATOM 2958 C CG    . LEU A 1 643 ? 119.484 103.218 117.567 1.00 36.81  ? 637 LEU A CG    1 
ATOM 2959 C CD1   . LEU A 1 643 ? 120.545 103.517 118.604 1.00 38.50  ? 637 LEU A CD1   1 
ATOM 2960 C CD2   . LEU A 1 643 ? 119.459 101.737 117.234 1.00 37.24  ? 637 LEU A CD2   1 
ATOM 2961 N N     . LYS A 1 644 ? 115.198 105.022 117.820 1.00 43.71  ? 638 LYS A N     1 
ATOM 2962 C CA    . LYS A 1 644 ? 113.890 105.311 118.394 1.00 42.72  ? 638 LYS A CA    1 
ATOM 2963 C C     . LYS A 1 644 ? 112.770 104.747 117.534 1.00 51.64  ? 638 LYS A C     1 
ATOM 2964 O O     . LYS A 1 644 ? 111.717 104.374 118.059 1.00 59.67  ? 638 LYS A O     1 
ATOM 2965 C CB    . LYS A 1 644 ? 113.718 106.818 118.578 1.00 43.29  ? 638 LYS A CB    1 
ATOM 2966 C CG    . LYS A 1 644 ? 112.732 107.185 119.667 1.00 49.40  ? 638 LYS A CG    1 
ATOM 2967 C CD    . LYS A 1 644 ? 113.073 108.517 120.310 1.00 54.80  ? 638 LYS A CD    1 
ATOM 2968 C CE    . LYS A 1 644 ? 112.780 109.675 119.378 1.00 57.24  ? 638 LYS A CE    1 
ATOM 2969 N NZ    . LYS A 1 644 ? 112.222 110.845 120.109 1.00 56.75  ? 638 LYS A NZ    1 
ATOM 2970 N N     . SER A 1 645 ? 112.975 104.681 116.218 1.00 48.02  ? 639 SER A N     1 
ATOM 2971 C CA    . SER A 1 645 ? 111.970 104.080 115.351 1.00 46.15  ? 639 SER A CA    1 
ATOM 2972 C C     . SER A 1 645 ? 111.962 102.560 115.458 1.00 47.01  ? 639 SER A C     1 
ATOM 2973 O O     . SER A 1 645 ? 110.892 101.944 115.483 1.00 50.08  ? 639 SER A O     1 
ATOM 2974 C CB    . SER A 1 645 ? 112.198 104.516 113.905 1.00 53.71  ? 639 SER A CB    1 
ATOM 2975 O OG    . SER A 1 645 ? 113.577 104.568 113.600 1.00 57.32  ? 639 SER A OG    1 
ATOM 2976 N N     . TRP A 1 646 ? 113.142 101.935 115.518 1.00 52.07  ? 640 TRP A N     1 
ATOM 2977 C CA    . TRP A 1 646 ? 113.199 100.478 115.626 1.00 47.69  ? 640 TRP A CA    1 
ATOM 2978 C C     . TRP A 1 646 ? 112.677 99.998  116.972 1.00 43.19  ? 640 TRP A C     1 
ATOM 2979 O O     . TRP A 1 646 ? 112.011 98.959  117.048 1.00 44.19  ? 640 TRP A O     1 
ATOM 2980 C CB    . TRP A 1 646 ? 114.623 99.975  115.404 1.00 43.43  ? 640 TRP A CB    1 
ATOM 2981 C CG    . TRP A 1 646 ? 114.849 98.604  115.973 1.00 45.17  ? 640 TRP A CG    1 
ATOM 2982 C CD1   . TRP A 1 646 ? 115.409 98.301  117.180 1.00 52.48  ? 640 TRP A CD1   1 
ATOM 2983 C CD2   . TRP A 1 646 ? 114.492 97.353  115.373 1.00 45.03  ? 640 TRP A CD2   1 
ATOM 2984 N NE1   . TRP A 1 646 ? 115.437 96.939  117.361 1.00 46.81  ? 640 TRP A NE1   1 
ATOM 2985 C CE2   . TRP A 1 646 ? 114.879 96.336  116.267 1.00 43.06  ? 640 TRP A CE2   1 
ATOM 2986 C CE3   . TRP A 1 646 ? 113.890 96.993  114.165 1.00 51.49  ? 640 TRP A CE3   1 
ATOM 2987 C CZ2   . TRP A 1 646 ? 114.684 94.987  115.990 1.00 52.27  ? 640 TRP A CZ2   1 
ATOM 2988 C CZ3   . TRP A 1 646 ? 113.697 95.653  113.895 1.00 43.72  ? 640 TRP A CZ3   1 
ATOM 2989 C CH2   . TRP A 1 646 ? 114.094 94.667  114.801 1.00 46.16  ? 640 TRP A CH2   1 
ATOM 2990 N N     . ASN A 1 647 ? 112.983 100.725 118.049 1.00 47.82  ? 641 ASN A N     1 
ATOM 2991 C CA    . ASN A 1 647 ? 112.494 100.333 119.366 1.00 51.01  ? 641 ASN A CA    1 
ATOM 2992 C C     . ASN A 1 647 ? 110.975 100.302 119.410 1.00 57.64  ? 641 ASN A C     1 
ATOM 2993 O O     . ASN A 1 647 ? 110.390 99.539  120.186 1.00 61.85  ? 641 ASN A O     1 
ATOM 2994 C CB    . ASN A 1 647 ? 113.037 101.283 120.433 1.00 50.61  ? 641 ASN A CB    1 
ATOM 2995 C CG    . ASN A 1 647 ? 114.428 100.906 120.896 1.00 55.27  ? 641 ASN A CG    1 
ATOM 2996 O OD1   . ASN A 1 647 ? 114.833 99.747  120.806 1.00 51.77  ? 641 ASN A OD1   1 
ATOM 2997 N ND2   . ASN A 1 647 ? 115.170 101.884 121.399 1.00 52.41  ? 641 ASN A ND2   1 
ATOM 2998 N N     . ARG A 1 648 ? 110.319 101.116 118.583 1.00 59.18  ? 642 ARG A N     1 
ATOM 2999 C CA    . ARG A 1 648 ? 108.867 101.170 118.515 1.00 60.64  ? 642 ARG A CA    1 
ATOM 3000 C C     . ARG A 1 648 ? 108.318 100.438 117.296 1.00 60.38  ? 642 ARG A C     1 
ATOM 3001 O O     . ARG A 1 648 ? 107.203 100.732 116.850 1.00 61.41  ? 642 ARG A O     1 
ATOM 3002 C CB    . ARG A 1 648 ? 108.399 102.625 118.535 1.00 61.09  ? 642 ARG A CB    1 
ATOM 3003 C CG    . ARG A 1 648 ? 108.031 103.110 119.926 1.00 62.48  ? 642 ARG A CG    1 
ATOM 3004 C CD    . ARG A 1 648 ? 107.790 104.609 119.974 1.00 62.48  ? 642 ARG A CD    1 
ATOM 3005 N NE    . ARG A 1 648 ? 108.976 105.356 120.374 1.00 63.08  ? 642 ARG A NE    1 
ATOM 3006 C CZ    . ARG A 1 648 ? 109.538 105.292 121.575 1.00 62.14  ? 642 ARG A CZ    1 
ATOM 3007 N NH1   . ARG A 1 648 ? 109.030 104.543 122.539 1.00 61.42  ? 642 ARG A NH1   1 
ATOM 3008 N NH2   . ARG A 1 648 ? 110.632 106.007 121.817 1.00 63.74  ? 642 ARG A NH2   1 
ATOM 3009 N N     . TYR A 1 649 ? 109.085 99.494  116.745 1.00 55.37  ? 643 TYR A N     1 
ATOM 3010 C CA    . TYR A 1 649 ? 108.581 98.644  115.671 1.00 58.60  ? 643 TYR A CA    1 
ATOM 3011 C C     . TYR A 1 649 ? 107.418 97.783  116.146 1.00 62.11  ? 643 TYR A C     1 
ATOM 3012 O O     . TYR A 1 649 ? 106.558 97.401  115.345 1.00 69.78  ? 643 TYR A O     1 
ATOM 3013 C CB    . TYR A 1 649 ? 109.719 97.769  115.137 1.00 58.59  ? 643 TYR A CB    1 
ATOM 3014 C CG    . TYR A 1 649 ? 109.415 96.989  113.875 1.00 57.04  ? 643 TYR A CG    1 
ATOM 3015 C CD1   . TYR A 1 649 ? 108.733 95.779  113.927 1.00 59.44  ? 643 TYR A CD1   1 
ATOM 3016 C CD2   . TYR A 1 649 ? 109.831 97.447  112.634 1.00 56.72  ? 643 TYR A CD2   1 
ATOM 3017 C CE1   . TYR A 1 649 ? 108.461 95.060  112.780 1.00 57.19  ? 643 TYR A CE1   1 
ATOM 3018 C CE2   . TYR A 1 649 ? 109.566 96.733  111.481 1.00 60.64  ? 643 TYR A CE2   1 
ATOM 3019 C CZ    . TYR A 1 649 ? 108.880 95.540  111.560 1.00 59.78  ? 643 TYR A CZ    1 
ATOM 3020 O OH    . TYR A 1 649 ? 108.611 94.825  110.416 1.00 56.95  ? 643 TYR A OH    1 
ATOM 3021 N N     . HIS A 1 650 ? 107.372 97.477  117.444 1.00 76.51  ? 644 HIS A N     1 
ATOM 3022 C CA    . HIS A 1 650 ? 106.343 96.590  117.976 1.00 76.02  ? 644 HIS A CA    1 
ATOM 3023 C C     . HIS A 1 650 ? 104.945 97.185  117.844 1.00 82.30  ? 644 HIS A C     1 
ATOM 3024 O O     . HIS A 1 650 ? 103.994 96.453  117.547 1.00 82.05  ? 644 HIS A O     1 
ATOM 3025 C CB    . HIS A 1 650 ? 106.638 96.270  119.441 1.00 74.54  ? 644 HIS A CB    1 
ATOM 3026 C CG    . HIS A 1 650 ? 105.679 95.300  120.058 1.00 80.65  ? 644 HIS A CG    1 
ATOM 3027 N ND1   . HIS A 1 650 ? 104.718 94.630  119.329 1.00 82.43  ? 644 HIS A ND1   1 
ATOM 3028 C CD2   . HIS A 1 650 ? 105.522 94.899  121.342 1.00 83.79  ? 644 HIS A CD2   1 
ATOM 3029 C CE1   . HIS A 1 650 ? 104.020 93.851  120.135 1.00 81.81  ? 644 HIS A CE1   1 
ATOM 3030 N NE2   . HIS A 1 650 ? 104.487 93.996  121.362 1.00 85.89  ? 644 HIS A NE2   1 
ATOM 3031 N N     . TRP A 1 651 ? 104.796 98.490  118.070 1.00 82.95  ? 645 TRP A N     1 
ATOM 3032 C CA    . TRP A 1 651 ? 103.467 99.071  118.204 1.00 77.02  ? 645 TRP A CA    1 
ATOM 3033 C C     . TRP A 1 651 ? 102.651 98.920  116.927 1.00 78.97  ? 645 TRP A C     1 
ATOM 3034 O O     . TRP A 1 651 ? 103.185 98.940  115.814 1.00 79.45  ? 645 TRP A O     1 
ATOM 3035 C CB    . TRP A 1 651 ? 103.550 100.551 118.587 1.00 73.47  ? 645 TRP A CB    1 
ATOM 3036 C CG    . TRP A 1 651 ? 104.192 100.847 119.916 1.00 76.14  ? 645 TRP A CG    1 
ATOM 3037 C CD1   . TRP A 1 651 ? 105.004 101.899 120.200 1.00 74.65  ? 645 TRP A CD1   1 
ATOM 3038 C CD2   . TRP A 1 651 ? 104.051 100.107 121.141 1.00 78.17  ? 645 TRP A CD2   1 
ATOM 3039 N NE1   . TRP A 1 651 ? 105.394 101.860 121.515 1.00 72.90  ? 645 TRP A NE1   1 
ATOM 3040 C CE2   . TRP A 1 651 ? 104.822 100.772 122.116 1.00 76.60  ? 645 TRP A CE2   1 
ATOM 3041 C CE3   . TRP A 1 651 ? 103.356 98.950  121.508 1.00 80.45  ? 645 TRP A CE3   1 
ATOM 3042 C CZ2   . TRP A 1 651 ? 104.919 100.316 123.428 1.00 79.06  ? 645 TRP A CZ2   1 
ATOM 3043 C CZ3   . TRP A 1 651 ? 103.455 98.501  122.810 1.00 80.14  ? 645 TRP A CZ3   1 
ATOM 3044 C CH2   . TRP A 1 651 ? 104.230 99.182  123.755 1.00 79.73  ? 645 TRP A CH2   1 
ATOM 3045 N N     . THR A 1 652 ? 101.341 98.766  117.106 1.00 96.23  ? 646 THR A N     1 
ATOM 3046 C CA    . THR A 1 652 ? 100.389 98.659  116.011 1.00 96.41  ? 646 THR A CA    1 
ATOM 3047 C C     . THR A 1 652 ? 99.300  99.709  116.190 1.00 97.01  ? 646 THR A C     1 
ATOM 3048 O O     . THR A 1 652 ? 99.449  100.622 117.010 1.00 98.71  ? 646 THR A O     1 
ATOM 3049 C CB    . THR A 1 652 ? 99.784  97.255  115.945 1.00 94.33  ? 646 THR A CB    1 
ATOM 3050 O OG1   . THR A 1 652 ? 98.763  97.220  114.940 1.00 91.72  ? 646 THR A OG1   1 
ATOM 3051 C CG2   . THR A 1 652 ? 99.183  96.869  117.287 1.00 92.79  ? 646 THR A CG2   1 
ATOM 3052 N N     . THR A 1 653 ? 98.215  99.591  115.429 1.00 101.06 ? 647 THR A N     1 
ATOM 3053 C CA    . THR A 1 653 ? 97.179  100.619 115.403 1.00 101.72 ? 647 THR A CA    1 
ATOM 3054 C C     . THR A 1 653 ? 96.630  100.892 116.799 1.00 102.67 ? 647 THR A C     1 
ATOM 3055 O O     . THR A 1 653 ? 95.989  100.030 117.407 1.00 103.99 ? 647 THR A O     1 
ATOM 3056 C CB    . THR A 1 653 ? 96.046  100.183 114.475 1.00 102.80 ? 647 THR A CB    1 
ATOM 3057 O OG1   . THR A 1 653 ? 95.147  99.328  115.192 1.00 99.88  ? 647 THR A OG1   1 
ATOM 3058 C CG2   . THR A 1 653 ? 96.603  99.421  113.284 1.00 103.21 ? 647 THR A CG2   1 
ATOM 3059 N N     . GLY A 1 654 ? 96.882  102.102 117.304 1.00 93.49  ? 648 GLY A N     1 
ATOM 3060 C CA    . GLY A 1 654 ? 96.271  102.580 118.525 1.00 93.76  ? 648 GLY A CA    1 
ATOM 3061 C C     . GLY A 1 654 ? 97.147  102.549 119.761 1.00 95.24  ? 648 GLY A C     1 
ATOM 3062 O O     . GLY A 1 654 ? 96.680  102.952 120.833 1.00 96.50  ? 648 GLY A O     1 
ATOM 3063 N N     . ASP A 1 655 ? 98.392  102.083 119.656 1.00 95.40  ? 649 ASP A N     1 
ATOM 3064 C CA    . ASP A 1 655 ? 99.251  102.024 120.837 1.00 95.05  ? 649 ASP A CA    1 
ATOM 3065 C C     . ASP A 1 655 ? 99.676  103.419 121.283 1.00 95.83  ? 649 ASP A C     1 
ATOM 3066 O O     . ASP A 1 655 ? 99.599  103.749 122.473 1.00 94.31  ? 649 ASP A O     1 
ATOM 3067 C CB    . ASP A 1 655 ? 100.466 101.141 120.557 1.00 94.92  ? 649 ASP A CB    1 
ATOM 3068 C CG    . ASP A 1 655 ? 100.087 99.695  120.311 1.00 95.52  ? 649 ASP A CG    1 
ATOM 3069 O OD1   . ASP A 1 655 ? 99.421  99.097  121.184 1.00 94.55  ? 649 ASP A OD1   1 
ATOM 3070 O OD2   . ASP A 1 655 ? 100.444 99.154  119.247 1.00 94.55  ? 649 ASP A OD2   1 
ATOM 3071 N N     . ARG A 1 656 ? 100.126 104.246 120.345 1.00 106.50 ? 650 ARG A N     1 
ATOM 3072 C CA    . ARG A 1 656 ? 100.473 105.661 120.588 1.00 106.23 ? 650 ARG A CA    1 
ATOM 3073 C C     . ARG A 1 656 ? 101.582 105.715 121.644 1.00 104.61 ? 650 ARG A C     1 
ATOM 3074 O O     . ARG A 1 656 ? 102.468 104.847 121.661 1.00 106.30 ? 650 ARG A O     1 
ATOM 3075 C CB    . ARG A 1 656 ? 99.225  106.441 120.944 1.00 105.59 ? 650 ARG A CB    1 
ATOM 3076 C CG    . ARG A 1 656 ? 98.236  106.602 119.807 1.00 105.56 ? 650 ARG A CG    1 
ATOM 3077 C CD    . ARG A 1 656 ? 97.179  107.640 120.149 1.00 104.36 ? 650 ARG A CD    1 
ATOM 3078 N NE    . ARG A 1 656 ? 97.722  108.992 120.156 1.00 107.26 ? 650 ARG A NE    1 
ATOM 3079 C CZ    . ARG A 1 656 ? 98.093  109.646 121.248 1.00 108.76 ? 650 ARG A CZ    1 
ATOM 3080 N NH1   . ARG A 1 656 ? 97.997  109.098 122.449 1.00 107.33 ? 650 ARG A NH1   1 
ATOM 3081 N NH2   . ARG A 1 656 ? 98.574  110.880 121.134 1.00 109.13 ? 650 ARG A NH2   1 
ATOM 3082 N N     . GLU A 1 657 ? 101.523 106.736 122.507 1.00 103.92 ? 651 GLU A N     1 
ATOM 3083 C CA    . GLU A 1 657 ? 102.535 106.898 123.585 1.00 105.65 ? 651 GLU A CA    1 
ATOM 3084 C C     . GLU A 1 657 ? 101.839 106.739 124.940 1.00 106.70 ? 651 GLU A C     1 
ATOM 3085 O O     . GLU A 1 657 ? 100.638 107.064 125.024 1.00 106.60 ? 651 GLU A O     1 
ATOM 3086 C CB    . GLU A 1 657 ? 103.193 108.274 123.481 1.00 30.00  ? 651 GLU A CB    1 
ATOM 3087 C CG    . GLU A 1 657 ? 104.707 108.217 123.397 1.00 30.00  ? 651 GLU A CG    1 
ATOM 3088 C CD    . GLU A 1 657 ? 105.415 108.418 124.725 1.00 30.00  ? 651 GLU A CD    1 
ATOM 3089 O OE1   . GLU A 1 657 ? 104.940 107.863 125.734 1.00 30.00  ? 651 GLU A OE1   1 
ATOM 3090 O OE2   . GLU A 1 657 ? 106.434 109.134 124.749 1.00 30.00  ? 651 GLU A OE2   1 
ATOM 3091 N N     . ARG A 1 658 ? 102.564 106.263 125.956 1.00 107.54 ? 652 ARG A N     1 
ATOM 3092 C CA    . ARG A 1 658 ? 101.959 106.040 127.297 1.00 106.97 ? 652 ARG A CA    1 
ATOM 3093 C C     . ARG A 1 658 ? 102.649 106.948 128.322 1.00 105.38 ? 652 ARG A C     1 
ATOM 3094 O O     . ARG A 1 658 ? 103.852 107.225 128.148 1.00 106.20 ? 652 ARG A O     1 
ATOM 3095 C CB    . ARG A 1 658 ? 102.057 104.560 127.683 1.00 106.25 ? 652 ARG A CB    1 
ATOM 3096 N N     . ARG A 1 659 ? 101.915 107.391 129.346 1.00 104.41 ? 653 ARG A N     1 
ATOM 3097 C CA    . ARG A 1 659 ? 102.494 108.307 130.322 1.00 105.03 ? 653 ARG A CA    1 
ATOM 3098 C C     . ARG A 1 659 ? 103.834 107.791 130.832 1.00 104.99 ? 653 ARG A C     1 
ATOM 3099 O O     . ARG A 1 659 ? 104.757 108.577 131.072 1.00 103.06 ? 653 ARG A O     1 
ATOM 3100 C CB    . ARG A 1 659 ? 101.524 108.521 131.482 1.00 106.13 ? 653 ARG A CB    1 
ATOM 3101 C CG    . ARG A 1 659 ? 101.993 109.545 132.507 1.00 107.73 ? 653 ARG A CG    1 
ATOM 3102 C CD    . ARG A 1 659 ? 101.813 110.964 131.988 1.00 106.99 ? 653 ARG A CD    1 
ATOM 3103 N NE    . ARG A 1 659 ? 103.070 111.701 131.951 1.00 107.05 ? 653 ARG A NE    1 
ATOM 3104 C CZ    . ARG A 1 659 ? 103.217 112.902 131.409 1.00 106.45 ? 653 ARG A CZ    1 
ATOM 3105 N NH1   . ARG A 1 659 ? 102.201 113.534 130.845 1.00 104.47 ? 653 ARG A NH1   1 
ATOM 3106 N NH2   . ARG A 1 659 ? 104.412 113.483 131.435 1.00 106.89 ? 653 ARG A NH2   1 
ATOM 3107 N N     . GLY A 1 660 ? 103.958 106.479 131.007 1.00 96.54  ? 654 GLY A N     1 
ATOM 3108 C CA    . GLY A 1 660 ? 105.208 105.889 131.441 1.00 96.23  ? 654 GLY A CA    1 
ATOM 3109 C C     . GLY A 1 660 ? 106.040 105.365 130.289 1.00 97.44  ? 654 GLY A C     1 
ATOM 3110 O O     . GLY A 1 660 ? 106.571 106.145 129.491 1.00 94.97  ? 654 GLY A O     1 
ATOM 3111 N N     . GLY A 1 661 ? 106.160 104.044 130.188 1.00 92.64  ? 655 GLY A N     1 
ATOM 3112 C CA    . GLY A 1 661 ? 106.930 103.436 129.121 1.00 88.90  ? 655 GLY A CA    1 
ATOM 3113 C C     . GLY A 1 661 ? 108.416 103.418 129.408 1.00 88.55  ? 655 GLY A C     1 
ATOM 3114 O O     . GLY A 1 661 ? 108.857 102.816 130.391 1.00 86.74  ? 655 GLY A O     1 
ATOM 3115 N N     . ASN A 1 662 ? 109.198 104.077 128.558 1.00 80.17  ? 656 ASN A N     1 
ATOM 3116 C CA    . ASN A 1 662 ? 110.638 104.176 128.757 1.00 77.28  ? 656 ASN A CA    1 
ATOM 3117 C C     . ASN A 1 662 ? 110.980 105.572 129.257 1.00 78.72  ? 656 ASN A C     1 
ATOM 3118 O O     . ASN A 1 662 ? 110.864 106.542 128.492 1.00 80.98  ? 656 ASN A O     1 
ATOM 3119 C CB    . ASN A 1 662 ? 111.386 103.875 127.459 1.00 77.28  ? 656 ASN A CB    1 
ATOM 3120 C CG    . ASN A 1 662 ? 110.781 102.715 126.696 1.00 77.10  ? 656 ASN A CG    1 
ATOM 3121 O OD1   . ASN A 1 662 ? 110.200 102.896 125.626 1.00 78.63  ? 656 ASN A OD1   1 
ATOM 3122 N ND2   . ASN A 1 662 ? 110.913 101.515 127.243 1.00 77.45  ? 656 ASN A ND2   1 
ATOM 3123 N N     . PRO A 1 663 ? 111.395 105.729 130.516 1.00 74.65  ? 657 PRO A N     1 
ATOM 3124 C CA    . PRO A 1 663 ? 111.685 107.072 131.036 1.00 75.46  ? 657 PRO A CA    1 
ATOM 3125 C C     . PRO A 1 663 ? 113.087 107.564 130.731 1.00 73.59  ? 657 PRO A C     1 
ATOM 3126 O O     . PRO A 1 663 ? 113.362 108.756 130.927 1.00 73.73  ? 657 PRO A O     1 
ATOM 3127 C CB    . PRO A 1 663 ? 111.483 106.900 132.545 1.00 73.83  ? 657 PRO A CB    1 
ATOM 3128 C CG    . PRO A 1 663 ? 111.878 105.472 132.800 1.00 73.33  ? 657 PRO A CG    1 
ATOM 3129 C CD    . PRO A 1 663 ? 111.610 104.684 131.533 1.00 71.79  ? 657 PRO A CD    1 
ATOM 3130 N N     . ASP A 1 664 ? 113.977 106.694 130.260 1.00 69.21  ? 658 ASP A N     1 
ATOM 3131 C CA    . ASP A 1 664 ? 115.357 107.056 129.965 1.00 68.63  ? 658 ASP A CA    1 
ATOM 3132 C C     . ASP A 1 664 ? 115.801 106.432 128.652 1.00 68.23  ? 658 ASP A C     1 
ATOM 3133 O O     . ASP A 1 664 ? 116.903 105.886 128.541 1.00 67.07  ? 658 ASP A O     1 
ATOM 3134 C CB    . ASP A 1 664 ? 116.285 106.649 131.108 1.00 64.56  ? 658 ASP A CB    1 
ATOM 3135 C CG    . ASP A 1 664 ? 116.182 105.175 131.449 1.00 68.56  ? 658 ASP A CG    1 
ATOM 3136 O OD1   . ASP A 1 664 ? 115.483 104.431 130.729 1.00 72.48  ? 658 ASP A OD1   1 
ATOM 3137 O OD2   . ASP A 1 664 ? 116.804 104.756 132.448 1.00 68.81  ? 658 ASP A OD2   1 
ATOM 3138 N N     . GLU A 1 665 ? 114.943 106.496 127.638 1.00 67.19  ? 659 GLU A N     1 
ATOM 3139 C CA    . GLU A 1 665 ? 115.264 105.900 126.349 1.00 63.97  ? 659 GLU A CA    1 
ATOM 3140 C C     . GLU A 1 665 ? 116.341 106.712 125.643 1.00 65.30  ? 659 GLU A C     1 
ATOM 3141 O O     . GLU A 1 665 ? 116.207 107.929 125.478 1.00 68.93  ? 659 GLU A O     1 
ATOM 3142 C CB    . GLU A 1 665 ? 114.012 105.815 125.481 1.00 61.54  ? 659 GLU A CB    1 
ATOM 3143 C CG    . GLU A 1 665 ? 113.856 104.493 124.755 1.00 61.59  ? 659 GLU A CG    1 
ATOM 3144 C CD    . GLU A 1 665 ? 113.095 104.634 123.455 1.00 67.99  ? 659 GLU A CD    1 
ATOM 3145 O OE1   . GLU A 1 665 ? 112.039 105.299 123.456 1.00 69.50  ? 659 GLU A OE1   1 
ATOM 3146 O OE2   . GLU A 1 665 ? 113.551 104.079 122.434 1.00 67.96  ? 659 GLU A OE2   1 
ATOM 3147 N N     . LEU A 1 666 ? 117.408 106.030 125.226 1.00 45.29  ? 660 LEU A N     1 
ATOM 3148 C CA    . LEU A 1 666 ? 118.517 106.654 124.501 1.00 44.81  ? 660 LEU A CA    1 
ATOM 3149 C C     . LEU A 1 666 ? 119.123 107.811 125.292 1.00 47.22  ? 660 LEU A C     1 
ATOM 3150 O O     . LEU A 1 666 ? 119.520 108.829 124.726 1.00 52.85  ? 660 LEU A O     1 
ATOM 3151 C CB    . LEU A 1 666 ? 118.078 107.118 123.113 1.00 43.75  ? 660 LEU A CB    1 
ATOM 3152 C CG    . LEU A 1 666 ? 117.370 106.086 122.235 1.00 45.85  ? 660 LEU A CG    1 
ATOM 3153 C CD1   . LEU A 1 666 ? 116.215 106.731 121.492 1.00 48.06  ? 660 LEU A CD1   1 
ATOM 3154 C CD2   . LEU A 1 666 ? 118.344 105.452 121.261 1.00 45.18  ? 660 LEU A CD2   1 
ATOM 3155 N N     . LYS A 1 667 ? 119.194 107.653 126.616 1.00 47.52  ? 661 LYS A N     1 
ATOM 3156 C CA    . LYS A 1 667 ? 119.778 108.699 127.451 1.00 42.65  ? 661 LYS A CA    1 
ATOM 3157 C C     . LYS A 1 667 ? 121.258 108.881 127.153 1.00 44.85  ? 661 LYS A C     1 
ATOM 3158 O O     . LYS A 1 667 ? 121.759 110.011 127.125 1.00 47.30  ? 661 LYS A O     1 
ATOM 3159 C CB    . LYS A 1 667 ? 119.568 108.377 128.927 1.00 46.84  ? 661 LYS A CB    1 
ATOM 3160 C CG    . LYS A 1 667 ? 119.729 109.579 129.842 1.00 45.44  ? 661 LYS A CG    1 
ATOM 3161 C CD    . LYS A 1 667 ? 118.990 109.383 131.154 1.00 48.92  ? 661 LYS A CD    1 
ATOM 3162 C CE    . LYS A 1 667 ? 119.436 108.110 131.851 1.00 50.82  ? 661 LYS A CE    1 
ATOM 3163 N NZ    . LYS A 1 667 ? 118.754 107.929 133.160 1.00 49.25  ? 661 LYS A NZ    1 
ATOM 3164 N N     . SER A 1 668 ? 121.977 107.777 126.933 1.00 43.26  ? 662 SER A N     1 
ATOM 3165 C CA    . SER A 1 668 ? 123.399 107.872 126.631 1.00 39.62  ? 662 SER A CA    1 
ATOM 3166 C C     . SER A 1 668 ? 123.634 108.593 125.311 1.00 44.66  ? 662 SER A C     1 
ATOM 3167 O O     . SER A 1 668 ? 124.567 109.394 125.192 1.00 47.90  ? 662 SER A O     1 
ATOM 3168 C CB    . SER A 1 668 ? 124.022 106.478 126.602 1.00 38.31  ? 662 SER A CB    1 
ATOM 3169 O OG    . SER A 1 668 ? 123.818 105.856 125.347 1.00 37.20  ? 662 SER A OG    1 
ATOM 3170 N N     . TYR A 1 669 ? 122.784 108.328 124.327 1.00 37.64  ? 663 TYR A N     1 
ATOM 3171 C CA    . TYR A 1 669 ? 122.917 108.991 123.038 1.00 26.91  ? 663 TYR A CA    1 
ATOM 3172 C C     . TYR A 1 669 ? 122.717 110.492 123.181 1.00 33.30  ? 663 TYR A C     1 
ATOM 3173 O O     . TYR A 1 669 ? 123.504 111.281 122.660 1.00 51.99  ? 663 TYR A O     1 
ATOM 3174 C CB    . TYR A 1 669 ? 121.919 108.410 122.039 1.00 32.01  ? 663 TYR A CB    1 
ATOM 3175 C CG    . TYR A 1 669 ? 122.292 107.028 121.563 1.00 38.63  ? 663 TYR A CG    1 
ATOM 3176 C CD1   . TYR A 1 669 ? 123.188 106.854 120.517 1.00 35.14  ? 663 TYR A CD1   1 
ATOM 3177 C CD2   . TYR A 1 669 ? 121.761 105.897 122.167 1.00 37.79  ? 663 TYR A CD2   1 
ATOM 3178 C CE1   . TYR A 1 669 ? 123.538 105.592 120.080 1.00 34.31  ? 663 TYR A CE1   1 
ATOM 3179 C CE2   . TYR A 1 669 ? 122.105 104.630 121.737 1.00 30.68  ? 663 TYR A CE2   1 
ATOM 3180 C CZ    . TYR A 1 669 ? 122.995 104.485 120.693 1.00 30.31  ? 663 TYR A CZ    1 
ATOM 3181 O OH    . TYR A 1 669 ? 123.345 103.229 120.257 1.00 35.26  ? 663 TYR A OH    1 
ATOM 3182 N N     . VAL A 1 670 ? 121.668 110.889 123.894 1.00 27.61  ? 664 VAL A N     1 
ATOM 3183 C CA    . VAL A 1 670 ? 121.388 112.310 124.079 1.00 35.92  ? 664 VAL A CA    1 
ATOM 3184 C C     . VAL A 1 670 ? 122.527 112.983 124.834 1.00 39.67  ? 664 VAL A C     1 
ATOM 3185 O O     . VAL A 1 670 ? 122.954 114.095 124.492 1.00 41.64  ? 664 VAL A O     1 
ATOM 3186 C CB    . VAL A 1 670 ? 120.039 112.498 124.797 1.00 26.92  ? 664 VAL A CB    1 
ATOM 3187 C CG1   . VAL A 1 670 ? 119.919 113.906 125.351 1.00 31.37  ? 664 VAL A CG1   1 
ATOM 3188 C CG2   . VAL A 1 670 ? 118.892 112.195 123.851 1.00 30.21  ? 664 VAL A CG2   1 
ATOM 3189 N N     . ARG A 1 671 ? 123.034 112.322 125.877 1.00 38.08  ? 665 ARG A N     1 
ATOM 3190 C CA    . ARG A 1 671 ? 124.156 112.864 126.635 1.00 32.67  ? 665 ARG A CA    1 
ATOM 3191 C C     . ARG A 1 671 ? 125.372 113.064 125.740 1.00 30.74  ? 665 ARG A C     1 
ATOM 3192 O O     . ARG A 1 671 ? 126.019 114.118 125.777 1.00 43.93  ? 665 ARG A O     1 
ATOM 3193 C CB    . ARG A 1 671 ? 124.493 111.930 127.793 1.00 37.55  ? 665 ARG A CB    1 
ATOM 3194 C CG    . ARG A 1 671 ? 124.895 112.625 129.074 1.00 41.40  ? 665 ARG A CG    1 
ATOM 3195 C CD    . ARG A 1 671 ? 124.894 111.639 130.227 1.00 37.91  ? 665 ARG A CD    1 
ATOM 3196 N NE    . ARG A 1 671 ? 125.588 110.408 129.870 1.00 44.19  ? 665 ARG A NE    1 
ATOM 3197 C CZ    . ARG A 1 671 ? 125.089 109.191 130.037 1.00 44.15  ? 665 ARG A CZ    1 
ATOM 3198 N NH1   . ARG A 1 671 ? 123.890 109.003 130.561 1.00 47.75  ? 665 ARG A NH1   1 
ATOM 3199 N NH2   . ARG A 1 671 ? 125.810 108.138 129.666 1.00 37.60  ? 665 ARG A NH2   1 
ATOM 3200 N N     . TYR A 1 672 ? 125.696 112.059 124.927 1.00 25.99  ? 666 TYR A N     1 
ATOM 3201 C CA    . TYR A 1 672 ? 126.834 112.171 124.023 1.00 19.44  ? 666 TYR A CA    1 
ATOM 3202 C C     . TYR A 1 672 ? 126.621 113.282 123.008 1.00 22.36  ? 666 TYR A C     1 
ATOM 3203 O O     . TYR A 1 672 ? 127.549 114.038 122.704 1.00 41.16  ? 666 TYR A O     1 
ATOM 3204 C CB    . TYR A 1 672 ? 127.076 110.840 123.316 1.00 29.35  ? 666 TYR A CB    1 
ATOM 3205 C CG    . TYR A 1 672 ? 128.155 110.895 122.259 1.00 32.44  ? 666 TYR A CG    1 
ATOM 3206 C CD1   . TYR A 1 672 ? 129.369 111.514 122.509 1.00 29.41  ? 666 TYR A CD1   1 
ATOM 3207 C CD2   . TYR A 1 672 ? 127.957 110.325 121.012 1.00 35.96  ? 666 TYR A CD2   1 
ATOM 3208 C CE1   . TYR A 1 672 ? 130.353 111.565 121.546 1.00 24.39  ? 666 TYR A CE1   1 
ATOM 3209 C CE2   . TYR A 1 672 ? 128.936 110.370 120.046 1.00 29.59  ? 666 TYR A CE2   1 
ATOM 3210 C CZ    . TYR A 1 672 ? 130.130 110.992 120.317 1.00 31.87  ? 666 TYR A CZ    1 
ATOM 3211 O OH    . TYR A 1 672 ? 131.106 111.039 119.353 1.00 46.74  ? 666 TYR A OH    1 
ATOM 3212 N N     . TYR A 1 673 ? 125.406 113.398 122.471 1.00 29.59  ? 667 TYR A N     1 
ATOM 3213 C CA    . TYR A 1 673 ? 125.125 114.433 121.483 1.00 32.62  ? 667 TYR A CA    1 
ATOM 3214 C C     . TYR A 1 673 ? 125.329 115.822 122.074 1.00 34.60  ? 667 TYR A C     1 
ATOM 3215 O O     . TYR A 1 673 ? 126.001 116.670 121.476 1.00 41.97  ? 667 TYR A O     1 
ATOM 3216 C CB    . TYR A 1 673 ? 123.701 114.271 120.954 1.00 30.98  ? 667 TYR A CB    1 
ATOM 3217 C CG    . TYR A 1 673 ? 123.250 115.375 120.027 1.00 34.26  ? 667 TYR A CG    1 
ATOM 3218 C CD1   . TYR A 1 673 ? 123.818 115.528 118.771 1.00 33.19  ? 667 TYR A CD1   1 
ATOM 3219 C CD2   . TYR A 1 673 ? 122.250 116.259 120.405 1.00 37.47  ? 667 TYR A CD2   1 
ATOM 3220 C CE1   . TYR A 1 673 ? 123.407 116.532 117.920 1.00 32.78  ? 667 TYR A CE1   1 
ATOM 3221 C CE2   . TYR A 1 673 ? 121.833 117.267 119.562 1.00 37.44  ? 667 TYR A CE2   1 
ATOM 3222 C CZ    . TYR A 1 673 ? 122.415 117.399 118.321 1.00 39.08  ? 667 TYR A CZ    1 
ATOM 3223 O OH    . TYR A 1 673 ? 122.002 118.401 117.476 1.00 46.41  ? 667 TYR A OH    1 
ATOM 3224 N N     . ASN A 1 674 ? 124.775 116.065 123.263 1.00 24.35  ? 668 ASN A N     1 
ATOM 3225 C CA    . ASN A 1 674 ? 124.914 117.381 123.880 1.00 14.64  ? 668 ASN A CA    1 
ATOM 3226 C C     . ASN A 1 674 ? 126.360 117.673 124.268 1.00 21.71  ? 668 ASN A C     1 
ATOM 3227 O O     . ASN A 1 674 ? 126.848 118.792 124.067 1.00 42.95  ? 668 ASN A O     1 
ATOM 3228 C CB    . ASN A 1 674 ? 124.001 117.491 125.099 1.00 23.19  ? 668 ASN A CB    1 
ATOM 3229 C CG    . ASN A 1 674 ? 122.571 117.814 124.722 1.00 38.10  ? 668 ASN A CG    1 
ATOM 3230 O OD1   . ASN A 1 674 ? 122.303 118.314 123.632 1.00 36.87  ? 668 ASN A OD1   1 
ATOM 3231 N ND2   . ASN A 1 674 ? 121.643 117.529 125.627 1.00 47.40  ? 668 ASN A ND2   1 
ATOM 3232 N N     . ASN A 1 675 ? 127.062 116.683 124.827 1.00 18.38  ? 669 ASN A N     1 
ATOM 3233 C CA    . ASN A 1 675 ? 128.452 116.894 125.213 1.00 17.94  ? 669 ASN A CA    1 
ATOM 3234 C C     . ASN A 1 675 ? 129.326 117.181 124.001 1.00 25.30  ? 669 ASN A C     1 
ATOM 3235 O O     . ASN A 1 675 ? 130.177 118.079 124.038 1.00 36.09  ? 669 ASN A O     1 
ATOM 3236 C CB    . ASN A 1 675 ? 128.970 115.675 125.972 1.00 21.89  ? 669 ASN A CB    1 
ATOM 3237 C CG    . ASN A 1 675 ? 128.307 115.502 127.320 1.00 26.03  ? 669 ASN A CG    1 
ATOM 3238 O OD1   . ASN A 1 675 ? 127.758 116.448 127.881 1.00 32.69  ? 669 ASN A OD1   1 
ATOM 3239 N ND2   . ASN A 1 675 ? 128.352 114.288 127.847 1.00 25.66  ? 669 ASN A ND2   1 
ATOM 3240 N N     . LEU A 1 676 ? 129.128 116.435 122.912 1.00 17.39  ? 670 LEU A N     1 
ATOM 3241 C CA    . LEU A 1 676 ? 129.903 116.674 121.701 1.00 14.49  ? 670 LEU A CA    1 
ATOM 3242 C C     . LEU A 1 676 ? 129.570 118.026 121.090 1.00 28.82  ? 670 LEU A C     1 
ATOM 3243 O O     . LEU A 1 676 ? 130.458 118.712 120.580 1.00 39.94  ? 670 LEU A O     1 
ATOM 3244 C CB    . LEU A 1 676 ? 129.660 115.555 120.693 1.00 16.75  ? 670 LEU A CB    1 
ATOM 3245 C CG    . LEU A 1 676 ? 130.409 115.680 119.366 1.00 18.74  ? 670 LEU A CG    1 
ATOM 3246 C CD1   . LEU A 1 676 ? 131.901 115.815 119.597 1.00 21.31  ? 670 LEU A CD1   1 
ATOM 3247 C CD2   . LEU A 1 676 ? 130.108 114.492 118.476 1.00 26.83  ? 670 LEU A CD2   1 
ATOM 3248 N N     . ARG A 1 677 ? 128.297 118.427 121.130 1.00 26.75  ? 671 ARG A N     1 
ATOM 3249 C CA    . ARG A 1 677 ? 127.922 119.744 120.624 1.00 19.45  ? 671 ARG A CA    1 
ATOM 3250 C C     . ARG A 1 677 ? 128.625 120.850 121.400 1.00 35.82  ? 671 ARG A C     1 
ATOM 3251 O O     . ARG A 1 677 ? 129.199 121.776 120.810 1.00 47.01  ? 671 ARG A O     1 
ATOM 3252 C CB    . ARG A 1 677 ? 126.407 119.911 120.709 1.00 22.84  ? 671 ARG A CB    1 
ATOM 3253 C CG    . ARG A 1 677 ? 125.829 120.907 119.733 1.00 34.06  ? 671 ARG A CG    1 
ATOM 3254 C CD    . ARG A 1 677 ? 124.326 120.766 119.667 1.00 29.61  ? 671 ARG A CD    1 
ATOM 3255 N NE    . ARG A 1 677 ? 123.702 121.168 120.919 1.00 38.90  ? 671 ARG A NE    1 
ATOM 3256 C CZ    . ARG A 1 677 ? 122.675 122.001 121.010 1.00 44.44  ? 671 ARG A CZ    1 
ATOM 3257 N NH1   . ARG A 1 677 ? 122.120 122.531 119.934 1.00 41.61  ? 671 ARG A NH1   1 
ATOM 3258 N NH2   . ARG A 1 677 ? 122.191 122.305 122.210 1.00 46.13  ? 671 ARG A NH2   1 
ATOM 3259 N N     . MET A 1 678 ? 128.599 120.760 122.731 1.00 30.29  ? 672 MET A N     1 
ATOM 3260 C CA    . MET A 1 678 ? 129.248 121.774 123.556 1.00 19.64  ? 672 MET A CA    1 
ATOM 3261 C C     . MET A 1 678 ? 130.753 121.798 123.322 1.00 6.73   ? 672 MET A C     1 
ATOM 3262 O O     . MET A 1 678 ? 131.357 122.875 123.215 1.00 23.71  ? 672 MET A O     1 
ATOM 3263 C CB    . MET A 1 678 ? 128.927 121.524 125.029 1.00 32.11  ? 672 MET A CB    1 
ATOM 3264 C CG    . MET A 1 678 ? 130.021 121.935 125.994 1.00 40.40  ? 672 MET A CG    1 
ATOM 3265 S SD    . MET A 1 678 ? 129.625 121.506 127.699 1.00 55.21  ? 672 MET A SD    1 
ATOM 3266 C CE    . MET A 1 678 ? 130.320 119.860 127.806 1.00 26.27  ? 672 MET A CE    1 
ATOM 3267 N N     . ASP A 1 679 ? 131.379 120.623 123.233 1.00 7.57   ? 673 ASP A N     1 
ATOM 3268 C CA    . ASP A 1 679 ? 132.819 120.577 123.004 1.00 21.93  ? 673 ASP A CA    1 
ATOM 3269 C C     . ASP A 1 679 ? 133.186 121.134 121.635 1.00 30.21  ? 673 ASP A C     1 
ATOM 3270 O O     . ASP A 1 679 ? 134.196 121.834 121.494 1.00 33.24  ? 673 ASP A O     1 
ATOM 3271 C CB    . ASP A 1 679 ? 133.332 119.149 123.157 1.00 25.65  ? 673 ASP A CB    1 
ATOM 3272 C CG    . ASP A 1 679 ? 134.735 119.099 123.719 1.00 42.70  ? 673 ASP A CG    1 
ATOM 3273 O OD1   . ASP A 1 679 ? 134.897 119.318 124.937 1.00 39.82  ? 673 ASP A OD1   1 
ATOM 3274 O OD2   . ASP A 1 679 ? 135.675 118.845 122.940 1.00 43.84  ? 673 ASP A OD2   1 
ATOM 3275 N N     . THR A 1 680 ? 132.385 120.832 120.612 1.00 26.46  ? 674 THR A N     1 
ATOM 3276 C CA    . THR A 1 680 ? 132.636 121.381 119.285 1.00 14.23  ? 674 THR A CA    1 
ATOM 3277 C C     . THR A 1 680 ? 132.525 122.897 119.295 1.00 22.79  ? 674 THR A C     1 
ATOM 3278 O O     . THR A 1 680 ? 133.355 123.591 118.697 1.00 34.22  ? 674 THR A O     1 
ATOM 3279 C CB    . THR A 1 680 ? 131.664 120.778 118.274 1.00 12.72  ? 674 THR A CB    1 
ATOM 3280 O OG1   . THR A 1 680 ? 131.916 119.374 118.147 1.00 32.90  ? 674 THR A OG1   1 
ATOM 3281 C CG2   . THR A 1 680 ? 131.829 121.433 116.915 1.00 21.38  ? 674 THR A CG2   1 
ATOM 3282 N N     . LEU A 1 681 ? 131.510 123.433 119.979 1.00 29.15  ? 675 LEU A N     1 
ATOM 3283 C CA    . LEU A 1 681 ? 131.368 124.884 120.066 1.00 22.10  ? 675 LEU A CA    1 
ATOM 3284 C C     . LEU A 1 681 ? 132.574 125.513 120.752 1.00 20.69  ? 675 LEU A C     1 
ATOM 3285 O O     . LEU A 1 681 ? 133.124 126.516 120.277 1.00 19.43  ? 675 LEU A O     1 
ATOM 3286 C CB    . LEU A 1 681 ? 130.082 125.240 120.809 1.00 25.34  ? 675 LEU A CB    1 
ATOM 3287 C CG    . LEU A 1 681 ? 129.633 126.696 120.698 1.00 24.89  ? 675 LEU A CG    1 
ATOM 3288 C CD1   . LEU A 1 681 ? 129.463 127.078 119.246 1.00 32.73  ? 675 LEU A CD1   1 
ATOM 3289 C CD2   . LEU A 1 681 ? 128.345 126.916 121.463 1.00 27.14  ? 675 LEU A CD2   1 
ATOM 3290 N N     . LYS A 1 682 ? 133.007 124.929 121.873 1.00 28.91  ? 676 LYS A N     1 
ATOM 3291 C CA    . LYS A 1 682 ? 134.148 125.483 122.598 1.00 25.19  ? 676 LYS A CA    1 
ATOM 3292 C C     . LYS A 1 682 ? 135.420 125.430 121.761 1.00 25.87  ? 676 LYS A C     1 
ATOM 3293 O O     . LYS A 1 682 ? 136.192 126.395 121.731 1.00 33.91  ? 676 LYS A O     1 
ATOM 3294 C CB    . LYS A 1 682 ? 134.349 124.742 123.918 1.00 23.27  ? 676 LYS A CB    1 
ATOM 3295 C CG    . LYS A 1 682 ? 133.228 124.940 124.920 1.00 16.38  ? 676 LYS A CG    1 
ATOM 3296 C CD    . LYS A 1 682 ? 133.318 123.926 126.040 1.00 21.76  ? 676 LYS A CD    1 
ATOM 3297 C CE    . LYS A 1 682 ? 132.811 124.504 127.346 1.00 35.77  ? 676 LYS A CE    1 
ATOM 3298 N NZ    . LYS A 1 682 ? 131.343 124.726 127.326 1.00 26.79  ? 676 LYS A NZ    1 
ATOM 3299 N N     . LYS A 1 683 ? 135.655 124.313 121.067 1.00 16.89  ? 677 LYS A N     1 
ATOM 3300 C CA    . LYS A 1 683 ? 136.871 124.192 120.269 1.00 21.56  ? 677 LYS A CA    1 
ATOM 3301 C C     . LYS A 1 683 ? 136.845 125.127 119.066 1.00 22.63  ? 677 LYS A C     1 
ATOM 3302 O O     . LYS A 1 683 ? 137.879 125.687 118.692 1.00 24.43  ? 677 LYS A O     1 
ATOM 3303 C CB    . LYS A 1 683 ? 137.068 122.742 119.828 1.00 24.49  ? 677 LYS A CB    1 
ATOM 3304 C CG    . LYS A 1 683 ? 137.307 121.784 120.979 1.00 24.27  ? 677 LYS A CG    1 
ATOM 3305 C CD    . LYS A 1 683 ? 138.542 120.936 120.757 1.00 18.67  ? 677 LYS A CD    1 
ATOM 3306 C CE    . LYS A 1 683 ? 138.262 119.478 121.061 1.00 18.99  ? 677 LYS A CE    1 
ATOM 3307 N NZ    . LYS A 1 683 ? 138.023 119.265 122.511 1.00 22.84  ? 677 LYS A NZ    1 
ATOM 3308 N N     . LEU A 1 684 ? 135.675 125.314 118.451 1.00 24.33  ? 678 LEU A N     1 
ATOM 3309 C CA    . LEU A 1 684 ? 135.569 126.263 117.345 1.00 18.06  ? 678 LEU A CA    1 
ATOM 3310 C C     . LEU A 1 684 ? 135.826 127.689 117.814 1.00 17.15  ? 678 LEU A C     1 
ATOM 3311 O O     . LEU A 1 684 ? 136.526 128.457 117.139 1.00 34.27  ? 678 LEU A O     1 
ATOM 3312 C CB    . LEU A 1 684 ? 134.193 126.152 116.696 1.00 21.54  ? 678 LEU A CB    1 
ATOM 3313 C CG    . LEU A 1 684 ? 133.932 127.055 115.493 1.00 17.64  ? 678 LEU A CG    1 
ATOM 3314 C CD1   . LEU A 1 684 ? 134.952 126.796 114.402 1.00 21.41  ? 678 LEU A CD1   1 
ATOM 3315 C CD2   . LEU A 1 684 ? 132.523 126.847 114.974 1.00 25.61  ? 678 LEU A CD2   1 
ATOM 3316 N N     . THR A 1 685 ? 135.264 128.065 118.966 1.00 17.57  ? 679 THR A N     1 
ATOM 3317 C CA    . THR A 1 685 ? 135.517 129.395 119.505 1.00 13.69  ? 679 THR A CA    1 
ATOM 3318 C C     . THR A 1 685 ? 136.994 129.587 119.818 1.00 17.77  ? 679 THR A C     1 
ATOM 3319 O O     . THR A 1 685 ? 137.572 130.638 119.514 1.00 21.38  ? 679 THR A O     1 
ATOM 3320 C CB    . THR A 1 685 ? 134.668 129.622 120.754 1.00 25.47  ? 679 THR A CB    1 
ATOM 3321 O OG1   . THR A 1 685 ? 133.290 129.737 120.381 1.00 33.95  ? 679 THR A OG1   1 
ATOM 3322 C CG2   . THR A 1 685 ? 135.098 130.884 121.465 1.00 23.84  ? 679 THR A CG2   1 
ATOM 3323 N N     . CYS A 1 686 ? 137.625 128.572 120.415 1.00 28.59  ? 680 CYS A N     1 
ATOM 3324 C CA    . CYS A 1 686 ? 139.050 128.663 120.711 1.00 21.70  ? 680 CYS A CA    1 
ATOM 3325 C C     . CYS A 1 686 ? 139.873 128.792 119.438 1.00 25.40  ? 680 CYS A C     1 
ATOM 3326 O O     . CYS A 1 686 ? 140.843 129.553 119.397 1.00 34.96  ? 680 CYS A O     1 
ATOM 3327 C CB    . CYS A 1 686 ? 139.503 127.448 121.515 1.00 24.84  ? 680 CYS A CB    1 
ATOM 3328 S SG    . CYS A 1 686 ? 141.286 127.393 121.790 1.00 42.24  ? 680 CYS A SG    1 
ATOM 3329 N N     . ALA A 1 687 ? 139.511 128.050 118.389 1.00 18.50  ? 681 ALA A N     1 
ATOM 3330 C CA    . ALA A 1 687 ? 140.239 128.147 117.127 1.00 14.38  ? 681 ALA A CA    1 
ATOM 3331 C C     . ALA A 1 687 ? 140.111 129.537 116.519 1.00 14.25  ? 681 ALA A C     1 
ATOM 3332 O O     . ALA A 1 687 ? 141.101 130.110 116.049 1.00 13.22  ? 681 ALA A O     1 
ATOM 3333 C CB    . ALA A 1 687 ? 139.738 127.085 116.149 1.00 12.95  ? 681 ALA A CB    1 
ATOM 3334 N N     . ILE A 1 688 ? 138.898 130.098 116.522 1.00 19.57  ? 682 ILE A N     1 
ATOM 3335 C CA    . ILE A 1 688 ? 138.697 131.439 115.974 1.00 17.07  ? 682 ILE A CA    1 
ATOM 3336 C C     . ILE A 1 688 ? 139.515 132.460 116.755 1.00 27.02  ? 682 ILE A C     1 
ATOM 3337 O O     . ILE A 1 688 ? 140.202 133.312 116.175 1.00 31.09  ? 682 ILE A O     1 
ATOM 3338 C CB    . ILE A 1 688 ? 137.201 131.804 115.972 1.00 16.96  ? 682 ILE A CB    1 
ATOM 3339 C CG1   . ILE A 1 688 ? 136.433 130.940 114.976 1.00 23.11  ? 682 ILE A CG1   1 
ATOM 3340 C CG2   . ILE A 1 688 ? 137.011 133.272 115.645 1.00 17.70  ? 682 ILE A CG2   1 
ATOM 3341 C CD1   . ILE A 1 688 ? 134.937 131.108 115.067 1.00 22.52  ? 682 ILE A CD1   1 
ATOM 3342 N N     . VAL A 1 689 ? 139.459 132.382 118.086 1.00 34.10  ? 683 VAL A N     1 
ATOM 3343 C CA    . VAL A 1 689 ? 140.177 133.336 118.924 1.00 23.04  ? 683 VAL A CA    1 
ATOM 3344 C C     . VAL A 1 689 ? 141.682 133.197 118.733 1.00 22.31  ? 683 VAL A C     1 
ATOM 3345 O O     . VAL A 1 689 ? 142.406 134.196 118.669 1.00 28.11  ? 683 VAL A O     1 
ATOM 3346 C CB    . VAL A 1 689 ? 139.767 133.153 120.395 1.00 25.43  ? 683 VAL A CB    1 
ATOM 3347 C CG1   . VAL A 1 689 ? 140.737 133.868 121.311 1.00 27.81  ? 683 VAL A CG1   1 
ATOM 3348 C CG2   . VAL A 1 689 ? 138.353 133.660 120.611 1.00 31.98  ? 683 VAL A CG2   1 
ATOM 3349 N N     . ARG A 1 690 ? 142.153 131.959 118.649 1.00 22.62  ? 684 ARG A N     1 
ATOM 3350 C CA    . ARG A 1 690 ? 143.572 131.729 118.437 1.00 22.41  ? 684 ARG A CA    1 
ATOM 3351 C C     . ARG A 1 690 ? 144.004 132.366 117.132 1.00 31.00  ? 684 ARG A C     1 
ATOM 3352 O O     . ARG A 1 690 ? 144.975 133.121 117.093 1.00 36.42  ? 684 ARG A O     1 
ATOM 3353 C CB    . ARG A 1 690 ? 143.869 130.232 118.413 1.00 23.87  ? 684 ARG A CB    1 
ATOM 3354 C CG    . ARG A 1 690 ? 145.045 129.819 119.280 1.00 36.34  ? 684 ARG A CG    1 
ATOM 3355 C CD    . ARG A 1 690 ? 145.210 128.309 119.290 1.00 39.57  ? 684 ARG A CD    1 
ATOM 3356 N NE    . ARG A 1 690 ? 144.401 127.681 120.329 1.00 36.22  ? 684 ARG A NE    1 
ATOM 3357 C CZ    . ARG A 1 690 ? 144.839 127.410 121.554 1.00 39.64  ? 684 ARG A CZ    1 
ATOM 3358 N NH1   . ARG A 1 690 ? 146.083 127.712 121.899 1.00 41.69  ? 684 ARG A NH1   1 
ATOM 3359 N NH2   . ARG A 1 690 ? 144.032 126.837 122.434 1.00 30.40  ? 684 ARG A NH2   1 
ATOM 3360 N N     . THR A 1 691 ? 143.277 132.071 116.060 1.00 33.78  ? 685 THR A N     1 
ATOM 3361 C CA    . THR A 1 691 ? 143.639 132.608 114.753 1.00 28.67  ? 685 THR A CA    1 
ATOM 3362 C C     . THR A 1 691 ? 143.640 134.131 114.762 1.00 31.03  ? 685 THR A C     1 
ATOM 3363 O O     . THR A 1 691 ? 144.515 134.759 114.157 1.00 36.59  ? 685 THR A O     1 
ATOM 3364 C CB    . THR A 1 691 ? 142.687 132.078 113.682 1.00 25.84  ? 685 THR A CB    1 
ATOM 3365 O OG1   . THR A 1 691 ? 142.615 130.651 113.770 1.00 32.16  ? 685 THR A OG1   1 
ATOM 3366 C CG2   . THR A 1 691 ? 143.180 132.460 112.304 1.00 27.30  ? 685 THR A CG2   1 
ATOM 3367 N N     . ALA A 1 692 ? 142.665 134.743 115.440 1.00 34.05  ? 686 ALA A N     1 
ATOM 3368 C CA    . ALA A 1 692 ? 142.633 136.202 115.522 1.00 27.03  ? 686 ALA A CA    1 
ATOM 3369 C C     . ALA A 1 692 ? 143.827 136.744 116.300 1.00 31.85  ? 686 ALA A C     1 
ATOM 3370 O O     . ALA A 1 692 ? 144.431 137.745 115.899 1.00 37.87  ? 686 ALA A O     1 
ATOM 3371 C CB    . ALA A 1 692 ? 141.325 136.667 116.158 1.00 24.72  ? 686 ALA A CB    1 
ATOM 3372 N N     . LYS A 1 693 ? 144.177 136.102 117.415 1.00 39.51  ? 687 LYS A N     1 
ATOM 3373 C CA    . LYS A 1 693 ? 145.285 136.581 118.237 1.00 33.85  ? 687 LYS A CA    1 
ATOM 3374 C C     . LYS A 1 693 ? 146.624 136.394 117.540 1.00 37.72  ? 687 LYS A C     1 
ATOM 3375 O O     . LYS A 1 693 ? 147.494 137.268 117.616 1.00 49.29  ? 687 LYS A O     1 
ATOM 3376 C CB    . LYS A 1 693 ? 145.291 135.860 119.582 1.00 34.98  ? 687 LYS A CB    1 
ATOM 3377 C CG    . LYS A 1 693 ? 144.319 136.421 120.594 1.00 35.42  ? 687 LYS A CG    1 
ATOM 3378 C CD    . LYS A 1 693 ? 144.110 135.444 121.736 1.00 43.26  ? 687 LYS A CD    1 
ATOM 3379 C CE    . LYS A 1 693 ? 145.433 135.039 122.363 1.00 36.00  ? 687 LYS A CE    1 
ATOM 3380 N NZ    . LYS A 1 693 ? 146.166 136.212 122.915 1.00 41.94  ? 687 LYS A NZ    1 
ATOM 3381 N N     . GLU A 1 694 ? 146.812 135.254 116.871 1.00 42.56  ? 688 GLU A N     1 
ATOM 3382 C CA    . GLU A 1 694 ? 148.083 134.969 116.213 1.00 44.65  ? 688 GLU A CA    1 
ATOM 3383 C C     . GLU A 1 694 ? 148.397 136.051 115.185 1.00 49.25  ? 688 GLU A C     1 
ATOM 3384 O O     . GLU A 1 694 ? 149.462 136.676 115.226 1.00 53.21  ? 688 GLU A O     1 
ATOM 3385 C CB    . GLU A 1 694 ? 148.003 133.585 115.561 1.00 48.81  ? 688 GLU A CB    1 
ATOM 3386 C CG    . GLU A 1 694 ? 149.207 133.042 114.767 1.00 52.65  ? 688 GLU A CG    1 
ATOM 3387 C CD    . GLU A 1 694 ? 150.571 133.537 115.228 1.00 57.42  ? 688 GLU A CD    1 
ATOM 3388 O OE1   . GLU A 1 694 ? 150.972 134.662 114.881 1.00 55.80  ? 688 GLU A OE1   1 
ATOM 3389 O OE2   . GLU A 1 694 ? 151.251 132.780 115.953 1.00 59.26  ? 688 GLU A OE2   1 
ATOM 3390 N N     . HIS A 1 695 ? 147.441 136.342 114.308 1.00 45.80  ? 689 HIS A N     1 
ATOM 3391 C CA    . HIS A 1 695 ? 147.641 137.301 113.231 1.00 42.69  ? 689 HIS A CA    1 
ATOM 3392 C C     . HIS A 1 695 ? 147.659 138.745 113.706 1.00 44.80  ? 689 HIS A C     1 
ATOM 3393 O O     . HIS A 1 695 ? 147.777 139.649 112.873 1.00 57.55  ? 689 HIS A O     1 
ATOM 3394 C CB    . HIS A 1 695 ? 146.559 137.115 112.170 1.00 40.27  ? 689 HIS A CB    1 
ATOM 3395 C CG    . HIS A 1 695 ? 146.807 135.950 111.266 1.00 41.50  ? 689 HIS A CG    1 
ATOM 3396 N ND1   . HIS A 1 695 ? 146.471 134.658 111.608 1.00 48.49  ? 689 HIS A ND1   1 
ATOM 3397 C CD2   . HIS A 1 695 ? 147.385 135.877 110.045 1.00 46.65  ? 689 HIS A CD2   1 
ATOM 3398 C CE1   . HIS A 1 695 ? 146.818 133.842 110.630 1.00 53.74  ? 689 HIS A CE1   1 
ATOM 3399 N NE2   . HIS A 1 695 ? 147.375 134.557 109.670 1.00 54.18  ? 689 HIS A NE2   1 
ATOM 3400 N N     . GLY A 1 696 ? 147.549 138.988 115.010 1.00 32.49  ? 690 GLY A N     1 
ATOM 3401 C CA    . GLY A 1 696 ? 147.591 140.342 115.517 1.00 31.24  ? 690 GLY A CA    1 
ATOM 3402 C C     . GLY A 1 696 ? 146.337 141.145 115.279 1.00 35.95  ? 690 GLY A C     1 
ATOM 3403 O O     . GLY A 1 696 ? 146.356 142.366 115.461 1.00 45.24  ? 690 GLY A O     1 
ATOM 3404 N N     . ALA A 1 697 ? 145.249 140.499 114.873 1.00 25.64  ? 691 ALA A N     1 
ATOM 3405 C CA    . ALA A 1 697 ? 144.020 141.213 114.570 1.00 22.79  ? 691 ALA A CA    1 
ATOM 3406 C C     . ALA A 1 697 ? 143.424 141.822 115.830 1.00 27.71  ? 691 ALA A C     1 
ATOM 3407 O O     . ALA A 1 697 ? 143.489 141.240 116.916 1.00 40.21  ? 691 ALA A O     1 
ATOM 3408 C CB    . ALA A 1 697 ? 143.009 140.273 113.915 1.00 20.08  ? 691 ALA A CB    1 
ATOM 3409 N N     . THR A 1 698 ? 142.852 143.013 115.678 1.00 27.83  ? 692 THR A N     1 
ATOM 3410 C CA    . THR A 1 698 ? 142.084 143.652 116.734 1.00 23.44  ? 692 THR A CA    1 
ATOM 3411 C C     . THR A 1 698 ? 140.651 143.941 116.326 1.00 31.83  ? 692 THR A C     1 
ATOM 3412 O O     . THR A 1 698 ? 139.829 144.241 117.198 1.00 41.69  ? 692 THR A O     1 
ATOM 3413 C CB    . THR A 1 698 ? 142.750 144.964 117.175 1.00 23.21  ? 692 THR A CB    1 
ATOM 3414 O OG1   . THR A 1 698 ? 141.970 145.571 118.210 1.00 28.84  ? 692 THR A OG1   1 
ATOM 3415 C CG2   . THR A 1 698 ? 142.862 145.924 116.005 1.00 35.76  ? 692 THR A CG2   1 
ATOM 3416 N N     . LEU A 1 699 ? 140.332 143.869 115.038 1.00 32.38  ? 693 LEU A N     1 
ATOM 3417 C CA    . LEU A 1 699 ? 138.966 143.971 114.553 1.00 26.25  ? 693 LEU A CA    1 
ATOM 3418 C C     . LEU A 1 699 ? 138.629 142.702 113.787 1.00 32.64  ? 693 LEU A C     1 
ATOM 3419 O O     . LEU A 1 699 ? 139.437 142.222 112.988 1.00 40.25  ? 693 LEU A O     1 
ATOM 3420 C CB    . LEU A 1 699 ? 138.789 145.193 113.653 1.00 24.51  ? 693 LEU A CB    1 
ATOM 3421 C CG    . LEU A 1 699 ? 138.524 146.520 114.361 1.00 32.45  ? 693 LEU A CG    1 
ATOM 3422 C CD1   . LEU A 1 699 ? 138.551 147.664 113.366 1.00 40.39  ? 693 LEU A CD1   1 
ATOM 3423 C CD2   . LEU A 1 699 ? 137.193 146.464 115.084 1.00 35.10  ? 693 LEU A CD2   1 
ATOM 3424 N N     . VAL A 1 700 ? 137.447 142.145 114.035 1.00 30.49  ? 694 VAL A N     1 
ATOM 3425 C CA    . VAL A 1 700 ? 137.027 140.910 113.386 1.00 21.91  ? 694 VAL A CA    1 
ATOM 3426 C C     . VAL A 1 700 ? 135.660 141.140 112.759 1.00 27.70  ? 694 VAL A C     1 
ATOM 3427 O O     . VAL A 1 700 ? 134.673 141.363 113.470 1.00 37.79  ? 694 VAL A O     1 
ATOM 3428 C CB    . VAL A 1 700 ? 136.988 139.723 114.358 1.00 27.00  ? 694 VAL A CB    1 
ATOM 3429 C CG1   . VAL A 1 700 ? 136.168 138.586 113.774 1.00 29.34  ? 694 VAL A CG1   1 
ATOM 3430 C CG2   . VAL A 1 700 ? 138.398 139.256 114.676 1.00 32.29  ? 694 VAL A CG2   1 
ATOM 3431 N N     . ALA A 1 701 ? 135.598 141.081 111.433 1.00 19.44  ? 695 ALA A N     1 
ATOM 3432 C CA    . ALA A 1 701 ? 134.341 141.132 110.700 1.00 16.11  ? 695 ALA A CA    1 
ATOM 3433 C C     . ALA A 1 701 ? 133.876 139.704 110.448 1.00 27.81  ? 695 ALA A C     1 
ATOM 3434 O O     . ALA A 1 701 ? 134.442 138.996 109.606 1.00 40.54  ? 695 ALA A O     1 
ATOM 3435 C CB    . ALA A 1 701 ? 134.508 141.899 109.394 1.00 24.17  ? 695 ALA A CB    1 
ATOM 3436 N N     . MET A 1 702 ? 132.856 139.280 111.183 1.00 24.12  ? 696 MET A N     1 
ATOM 3437 C CA    . MET A 1 702 ? 132.250 137.972 110.994 1.00 25.43  ? 696 MET A CA    1 
ATOM 3438 C C     . MET A 1 702 ? 131.022 138.101 110.107 1.00 30.10  ? 696 MET A C     1 
ATOM 3439 O O     . MET A 1 702 ? 130.531 139.198 109.842 1.00 42.99  ? 696 MET A O     1 
ATOM 3440 C CB    . MET A 1 702 ? 131.874 137.353 112.341 1.00 31.62  ? 696 MET A CB    1 
ATOM 3441 C CG    . MET A 1 702 ? 132.972 136.522 112.970 1.00 37.66  ? 696 MET A CG    1 
ATOM 3442 S SD    . MET A 1 702 ? 132.503 135.936 114.604 1.00 71.94  ? 696 MET A SD    1 
ATOM 3443 C CE    . MET A 1 702 ? 131.306 137.181 115.078 1.00 39.32  ? 696 MET A CE    1 
ATOM 3444 N N     . GLU A 1 703 ? 130.526 136.963 109.639 1.00 33.16  ? 697 GLU A N     1 
ATOM 3445 C CA    . GLU A 1 703 ? 129.331 136.937 108.811 1.00 44.44  ? 697 GLU A CA    1 
ATOM 3446 C C     . GLU A 1 703 ? 128.115 136.626 109.673 1.00 42.18  ? 697 GLU A C     1 
ATOM 3447 O O     . GLU A 1 703 ? 128.150 135.735 110.526 1.00 47.99  ? 697 GLU A O     1 
ATOM 3448 C CB    . GLU A 1 703 ? 129.474 135.927 107.666 1.00 37.77  ? 697 GLU A CB    1 
ATOM 3449 C CG    . GLU A 1 703 ? 129.333 134.467 108.039 1.00 39.12  ? 697 GLU A CG    1 
ATOM 3450 C CD    . GLU A 1 703 ? 128.918 133.617 106.856 1.00 52.19  ? 697 GLU A CD    1 
ATOM 3451 O OE1   . GLU A 1 703 ? 129.104 134.075 105.708 1.00 51.79  ? 697 GLU A OE1   1 
ATOM 3452 O OE2   . GLU A 1 703 ? 128.412 132.496 107.067 1.00 55.70  ? 697 GLU A OE2   1 
ATOM 3453 N N     . ASN A 1 704 ? 127.047 137.395 109.467 1.00 41.47  ? 698 ASN A N     1 
ATOM 3454 C CA    . ASN A 1 704 ? 125.854 137.320 110.308 1.00 46.30  ? 698 ASN A CA    1 
ATOM 3455 C C     . ASN A 1 704 ? 125.013 136.128 109.861 1.00 57.79  ? 698 ASN A C     1 
ATOM 3456 O O     . ASN A 1 704 ? 124.053 136.246 109.097 1.00 66.93  ? 698 ASN A O     1 
ATOM 3457 C CB    . ASN A 1 704 ? 125.069 138.623 110.238 1.00 48.55  ? 698 ASN A CB    1 
ATOM 3458 C CG    . ASN A 1 704 ? 124.000 138.717 111.304 1.00 54.86  ? 698 ASN A CG    1 
ATOM 3459 O OD1   . ASN A 1 704 ? 124.119 138.122 112.372 1.00 57.81  ? 698 ASN A OD1   1 
ATOM 3460 N ND2   . ASN A 1 704 ? 122.950 139.476 111.020 1.00 56.40  ? 698 ASN A ND2   1 
ATOM 3461 N N     . ILE A 1 705 ? 125.375 134.950 110.376 1.00 61.30  ? 699 ILE A N     1 
ATOM 3462 C CA    . ILE A 1 705 ? 124.717 133.712 109.985 1.00 55.38  ? 699 ILE A CA    1 
ATOM 3463 C C     . ILE A 1 705 ? 123.255 133.663 110.404 1.00 57.73  ? 699 ILE A C     1 
ATOM 3464 O O     . ILE A 1 705 ? 122.558 132.702 110.068 1.00 63.64  ? 699 ILE A O     1 
ATOM 3465 C CB    . ILE A 1 705 ? 125.472 132.495 110.559 1.00 55.42  ? 699 ILE A CB    1 
ATOM 3466 C CG1   . ILE A 1 705 ? 125.578 132.596 112.081 1.00 59.65  ? 699 ILE A CG1   1 
ATOM 3467 C CG2   . ILE A 1 705 ? 126.851 132.385 109.938 1.00 52.86  ? 699 ILE A CG2   1 
ATOM 3468 C CD1   . ILE A 1 705 ? 126.275 131.415 112.717 1.00 61.42  ? 699 ILE A CD1   1 
ATOM 3469 N N     . GLN A 1 706 ? 122.773 134.667 111.140 1.00 64.12  ? 700 GLN A N     1 
ATOM 3470 C CA    . GLN A 1 706 ? 121.348 134.738 111.442 1.00 62.35  ? 700 GLN A CA    1 
ATOM 3471 C C     . GLN A 1 706 ? 120.528 134.946 110.177 1.00 69.06  ? 700 GLN A C     1 
ATOM 3472 O O     . GLN A 1 706 ? 119.446 134.367 110.024 1.00 74.93  ? 700 GLN A O     1 
ATOM 3473 C CB    . GLN A 1 706 ? 121.080 135.856 112.447 1.00 58.55  ? 700 GLN A CB    1 
ATOM 3474 C CG    . GLN A 1 706 ? 120.808 135.365 113.855 1.00 67.09  ? 700 GLN A CG    1 
ATOM 3475 C CD    . GLN A 1 706 ? 121.058 136.430 114.900 1.00 77.62  ? 700 GLN A CD    1 
ATOM 3476 O OE1   . GLN A 1 706 ? 121.926 137.287 114.734 1.00 78.96  ? 700 GLN A OE1   1 
ATOM 3477 N NE2   . GLN A 1 706 ? 120.299 136.381 115.988 1.00 74.43  ? 700 GLN A NE2   1 
ATOM 3478 N N     . ARG A 1 707 ? 121.022 135.772 109.260 1.00 72.27  ? 701 ARG A N     1 
ATOM 3479 C CA    . ARG A 1 707 ? 120.326 136.034 108.007 1.00 69.96  ? 701 ARG A CA    1 
ATOM 3480 C C     . ARG A 1 707 ? 120.506 134.877 107.032 1.00 69.90  ? 701 ARG A C     1 
ATOM 3481 O O     . ARG A 1 707 ? 121.627 134.440 106.774 1.00 71.17  ? 701 ARG A O     1 
ATOM 3482 C CB    . ARG A 1 707 ? 120.825 137.338 107.381 1.00 66.20  ? 701 ARG A CB    1 
ATOM 3483 C CG    . ARG A 1 707 ? 121.169 138.415 108.393 1.00 67.27  ? 701 ARG A CG    1 
ATOM 3484 C CD    . ARG A 1 707 ? 121.147 139.805 107.765 1.00 71.62  ? 701 ARG A CD    1 
ATOM 3485 N NE    . ARG A 1 707 ? 119.804 140.370 107.661 1.00 75.98  ? 701 ARG A NE    1 
ATOM 3486 C CZ    . ARG A 1 707 ? 119.017 140.663 108.689 1.00 75.29  ? 701 ARG A CZ    1 
ATOM 3487 N NH1   . ARG A 1 707 ? 119.413 140.488 109.940 1.00 74.65  ? 701 ARG A NH1   1 
ATOM 3488 N NH2   . ARG A 1 707 ? 117.803 141.152 108.454 1.00 69.50  ? 701 ARG A NH2   1 
ATOM 3489 N N     . GLU A 1 719 ? 120.655 118.776 108.080 1.00 78.43  ? 713 GLU A N     1 
ATOM 3490 C CA    . GLU A 1 719 ? 121.203 119.320 106.843 1.00 77.66  ? 713 GLU A CA    1 
ATOM 3491 C C     . GLU A 1 719 ? 122.720 119.428 106.918 1.00 74.23  ? 713 GLU A C     1 
ATOM 3492 O O     . GLU A 1 719 ? 123.366 118.695 107.663 1.00 75.34  ? 713 GLU A O     1 
ATOM 3493 C CB    . GLU A 1 719 ? 120.590 120.686 106.541 1.00 78.81  ? 713 GLU A CB    1 
ATOM 3494 C CG    . GLU A 1 719 ? 119.090 120.754 106.769 1.00 75.81  ? 713 GLU A CG    1 
ATOM 3495 C CD    . GLU A 1 719 ? 118.559 122.171 106.703 1.00 80.17  ? 713 GLU A CD    1 
ATOM 3496 O OE1   . GLU A 1 719 ? 118.240 122.636 105.588 1.00 79.65  ? 713 GLU A OE1   1 
ATOM 3497 O OE2   . GLU A 1 719 ? 118.460 122.819 107.764 1.00 79.34  ? 713 GLU A OE2   1 
ATOM 3498 N N     . ASN A 1 720 ? 123.282 120.348 106.140 1.00 66.76  ? 714 ASN A N     1 
ATOM 3499 C CA    . ASN A 1 720 ? 124.727 120.532 106.023 1.00 69.08  ? 714 ASN A CA    1 
ATOM 3500 C C     . ASN A 1 720 ? 125.104 121.979 106.309 1.00 70.95  ? 714 ASN A C     1 
ATOM 3501 O O     . ASN A 1 720 ? 125.873 122.606 105.578 1.00 72.24  ? 714 ASN A O     1 
ATOM 3502 C CB    . ASN A 1 720 ? 125.220 120.117 104.638 1.00 67.41  ? 714 ASN A CB    1 
ATOM 3503 C CG    . ASN A 1 720 ? 125.013 118.640 104.357 1.00 74.04  ? 714 ASN A CG    1 
ATOM 3504 O OD1   . ASN A 1 720 ? 124.555 117.889 105.216 1.00 73.26  ? 714 ASN A OD1   1 
ATOM 3505 N ND2   . ASN A 1 720 ? 125.353 118.217 103.146 1.00 75.36  ? 714 ASN A ND2   1 
ATOM 3506 N N     . SER A 1 721 ? 124.563 122.532 107.392 1.00 52.12  ? 715 SER A N     1 
ATOM 3507 C CA    . SER A 1 721 ? 124.816 123.918 107.756 1.00 49.25  ? 715 SER A CA    1 
ATOM 3508 C C     . SER A 1 721 ? 125.038 124.018 109.257 1.00 50.88  ? 715 SER A C     1 
ATOM 3509 O O     . SER A 1 721 ? 124.719 123.099 110.015 1.00 49.46  ? 715 SER A O     1 
ATOM 3510 C CB    . SER A 1 721 ? 123.661 124.833 107.333 1.00 55.35  ? 715 SER A CB    1 
ATOM 3511 O OG    . SER A 1 721 ? 122.434 124.394 107.890 1.00 57.12  ? 715 SER A OG    1 
ATOM 3512 N N     . LEU A 1 722 ? 125.611 125.149 109.678 1.00 52.17  ? 716 LEU A N     1 
ATOM 3513 C CA    . LEU A 1 722 ? 125.802 125.396 111.104 1.00 39.45  ? 716 LEU A CA    1 
ATOM 3514 C C     . LEU A 1 722 ? 124.465 125.470 111.825 1.00 39.98  ? 716 LEU A C     1 
ATOM 3515 O O     . LEU A 1 722 ? 124.332 124.989 112.956 1.00 45.68  ? 716 LEU A O     1 
ATOM 3516 C CB    . LEU A 1 722 ? 126.599 126.682 111.317 1.00 38.89  ? 716 LEU A CB    1 
ATOM 3517 C CG    . LEU A 1 722 ? 128.114 126.535 111.454 1.00 37.85  ? 716 LEU A CG    1 
ATOM 3518 C CD1   . LEU A 1 722 ? 128.710 127.799 112.041 1.00 43.47  ? 716 LEU A CD1   1 
ATOM 3519 C CD2   . LEU A 1 722 ? 128.461 125.335 112.311 1.00 40.96  ? 716 LEU A CD2   1 
ATOM 3520 N N     . LEU A 1 723 ? 123.465 126.076 111.193 1.00 43.49  ? 717 LEU A N     1 
ATOM 3521 C CA    . LEU A 1 723 ? 122.109 126.004 111.704 1.00 45.79  ? 717 LEU A CA    1 
ATOM 3522 C C     . LEU A 1 723 ? 121.623 124.556 111.643 1.00 53.74  ? 717 LEU A C     1 
ATOM 3523 O O     . LEU A 1 723 ? 122.226 123.696 110.999 1.00 54.67  ? 717 LEU A O     1 
ATOM 3524 C CB    . LEU A 1 723 ? 121.188 126.926 110.908 1.00 46.94  ? 717 LEU A CB    1 
ATOM 3525 C CG    . LEU A 1 723 ? 121.395 128.426 111.124 1.00 51.80  ? 717 LEU A CG    1 
ATOM 3526 C CD1   . LEU A 1 723 ? 122.387 128.988 110.117 1.00 48.91  ? 717 LEU A CD1   1 
ATOM 3527 C CD2   . LEU A 1 723 ? 120.073 129.169 111.045 1.00 51.02  ? 717 LEU A CD2   1 
ATOM 3528 N N     . SER A 1 724 ? 120.517 124.293 112.341 1.00 47.39  ? 718 SER A N     1 
ATOM 3529 C CA    . SER A 1 724 ? 119.979 122.963 112.617 1.00 47.46  ? 718 SER A CA    1 
ATOM 3530 C C     . SER A 1 724 ? 120.849 122.189 113.596 1.00 49.60  ? 718 SER A C     1 
ATOM 3531 O O     . SER A 1 724 ? 120.484 121.072 113.980 1.00 56.66  ? 718 SER A O     1 
ATOM 3532 C CB    . SER A 1 724 ? 119.784 122.118 111.348 1.00 51.21  ? 718 SER A CB    1 
ATOM 3533 O OG    . SER A 1 724 ? 120.972 121.419 111.025 1.00 44.87  ? 718 SER A OG    1 
ATOM 3534 N N     . LEU A 1 725 ? 121.982 122.739 114.012 1.00 39.76  ? 719 LEU A N     1 
ATOM 3535 C CA    . LEU A 1 725 ? 122.806 122.202 115.084 1.00 38.52  ? 719 LEU A CA    1 
ATOM 3536 C C     . LEU A 1 725 ? 122.857 123.121 116.291 1.00 40.20  ? 719 LEU A C     1 
ATOM 3537 O O     . LEU A 1 725 ? 122.838 122.644 117.428 1.00 48.94  ? 719 LEU A O     1 
ATOM 3538 C CB    . LEU A 1 725 ? 124.233 121.947 114.580 1.00 34.98  ? 719 LEU A CB    1 
ATOM 3539 C CG    . LEU A 1 725 ? 124.539 120.559 114.023 1.00 36.41  ? 719 LEU A CG    1 
ATOM 3540 C CD1   . LEU A 1 725 ? 125.977 120.491 113.546 1.00 34.46  ? 719 LEU A CD1   1 
ATOM 3541 C CD2   . LEU A 1 725 ? 124.271 119.497 115.069 1.00 38.82  ? 719 LEU A CD2   1 
ATOM 3542 N N     . TRP A 1 726 ? 122.917 124.431 116.067 1.00 35.02  ? 720 TRP A N     1 
ATOM 3543 C CA    . TRP A 1 726 ? 122.893 125.432 117.120 1.00 38.84  ? 720 TRP A CA    1 
ATOM 3544 C C     . TRP A 1 726 ? 121.851 126.486 116.777 1.00 40.42  ? 720 TRP A C     1 
ATOM 3545 O O     . TRP A 1 726 ? 121.323 126.533 115.665 1.00 51.06  ? 720 TRP A O     1 
ATOM 3546 C CB    . TRP A 1 726 ? 124.256 126.115 117.292 1.00 26.83  ? 720 TRP A CB    1 
ATOM 3547 C CG    . TRP A 1 726 ? 125.288 125.285 117.960 1.00 31.76  ? 720 TRP A CG    1 
ATOM 3548 C CD1   . TRP A 1 726 ? 125.388 125.018 119.290 1.00 37.01  ? 720 TRP A CD1   1 
ATOM 3549 C CD2   . TRP A 1 726 ? 126.394 124.632 117.333 1.00 35.14  ? 720 TRP A CD2   1 
ATOM 3550 N NE1   . TRP A 1 726 ? 126.482 124.225 119.531 1.00 39.88  ? 720 TRP A NE1   1 
ATOM 3551 C CE2   . TRP A 1 726 ? 127.117 123.975 118.343 1.00 38.05  ? 720 TRP A CE2   1 
ATOM 3552 C CE3   . TRP A 1 726 ? 126.840 124.534 116.012 1.00 36.46  ? 720 TRP A CE3   1 
ATOM 3553 C CZ2   . TRP A 1 726 ? 128.260 123.229 118.076 1.00 37.06  ? 720 TRP A CZ2   1 
ATOM 3554 C CZ3   . TRP A 1 726 ? 127.973 123.793 115.750 1.00 29.26  ? 720 TRP A CZ3   1 
ATOM 3555 C CH2   . TRP A 1 726 ? 128.670 123.151 116.776 1.00 32.32  ? 720 TRP A CH2   1 
ATOM 3556 N N     . ALA A 1 727 ? 121.556 127.334 117.751 1.00 46.70  ? 721 ALA A N     1 
ATOM 3557 C CA    . ALA A 1 727 ? 120.832 128.553 117.448 1.00 46.61  ? 721 ALA A CA    1 
ATOM 3558 C C     . ALA A 1 727 ? 121.715 129.459 116.597 1.00 54.15  ? 721 ALA A C     1 
ATOM 3559 O O     . ALA A 1 727 ? 122.937 129.474 116.773 1.00 66.54  ? 721 ALA A O     1 
ATOM 3560 C CB    . ALA A 1 727 ? 120.425 129.272 118.733 1.00 57.09  ? 721 ALA A CB    1 
ATOM 3561 N N     . PRO A 1 728 ? 121.140 130.210 115.656 1.00 62.00  ? 722 PRO A N     1 
ATOM 3562 C CA    . PRO A 1 728 ? 121.977 131.071 114.808 1.00 59.80  ? 722 PRO A CA    1 
ATOM 3563 C C     . PRO A 1 728 ? 122.769 132.100 115.593 1.00 62.92  ? 722 PRO A C     1 
ATOM 3564 O O     . PRO A 1 728 ? 123.893 132.435 115.200 1.00 63.67  ? 722 PRO A O     1 
ATOM 3565 C CB    . PRO A 1 728 ? 120.961 131.731 113.868 1.00 61.89  ? 722 PRO A CB    1 
ATOM 3566 C CG    . PRO A 1 728 ? 119.663 131.656 114.597 1.00 64.18  ? 722 PRO A CG    1 
ATOM 3567 C CD    . PRO A 1 728 ? 119.706 130.369 115.361 1.00 65.42  ? 722 PRO A CD    1 
ATOM 3568 N N     . GLY A 1 729 ? 122.222 132.603 116.696 1.00 65.29  ? 723 GLY A N     1 
ATOM 3569 C CA    . GLY A 1 729 ? 122.886 133.636 117.464 1.00 62.09  ? 723 GLY A CA    1 
ATOM 3570 C C     . GLY A 1 729 ? 123.798 133.137 118.565 1.00 63.54  ? 723 GLY A C     1 
ATOM 3571 O O     . GLY A 1 729 ? 124.643 133.892 119.050 1.00 67.40  ? 723 GLY A O     1 
ATOM 3572 N N     . MET A 1 730 ? 123.646 131.874 118.973 1.00 59.10  ? 724 MET A N     1 
ATOM 3573 C CA    . MET A 1 730 ? 124.440 131.354 120.082 1.00 62.31  ? 724 MET A CA    1 
ATOM 3574 C C     . MET A 1 730 ? 125.919 131.283 119.721 1.00 62.33  ? 724 MET A C     1 
ATOM 3575 O O     . MET A 1 730 ? 126.787 131.682 120.510 1.00 70.18  ? 724 MET A O     1 
ATOM 3576 C CB    . MET A 1 730 ? 123.919 129.979 120.498 1.00 61.02  ? 724 MET A CB    1 
ATOM 3577 C CG    . MET A 1 730 ? 124.959 129.092 121.162 1.00 60.03  ? 724 MET A CG    1 
ATOM 3578 S SD    . MET A 1 730 ? 124.262 127.614 121.922 1.00 74.61  ? 724 MET A SD    1 
ATOM 3579 C CE    . MET A 1 730 ? 122.724 127.450 121.020 1.00 57.59  ? 724 MET A CE    1 
ATOM 3580 N N     . VAL A 1 731 ? 126.226 130.772 118.526 1.00 52.84  ? 725 VAL A N     1 
ATOM 3581 C CA    . VAL A 1 731 ? 127.614 130.676 118.085 1.00 52.93  ? 725 VAL A CA    1 
ATOM 3582 C C     . VAL A 1 731 ? 128.240 132.061 118.020 1.00 58.26  ? 725 VAL A C     1 
ATOM 3583 O O     . VAL A 1 731 ? 129.359 132.284 118.505 1.00 65.29  ? 725 VAL A O     1 
ATOM 3584 C CB    . VAL A 1 731 ? 127.696 129.961 116.724 1.00 52.45  ? 725 VAL A CB    1 
ATOM 3585 C CG1   . VAL A 1 731 ? 129.092 129.405 116.498 1.00 52.56  ? 725 VAL A CG1   1 
ATOM 3586 C CG2   . VAL A 1 731 ? 126.655 128.859 116.640 1.00 51.79  ? 725 VAL A CG2   1 
ATOM 3587 N N     . LEU A 1 732 ? 127.522 133.013 117.425 1.00 48.84  ? 726 LEU A N     1 
ATOM 3588 C CA    . LEU A 1 732 ? 128.040 134.371 117.315 1.00 48.69  ? 726 LEU A CA    1 
ATOM 3589 C C     . LEU A 1 732 ? 128.265 134.985 118.687 1.00 55.21  ? 726 LEU A C     1 
ATOM 3590 O O     . LEU A 1 732 ? 129.296 135.621 118.926 1.00 62.72  ? 726 LEU A O     1 
ATOM 3591 C CB    . LEU A 1 732 ? 127.079 135.229 116.494 1.00 56.76  ? 726 LEU A CB    1 
ATOM 3592 C CG    . LEU A 1 732 ? 126.979 134.900 115.004 1.00 56.82  ? 726 LEU A CG    1 
ATOM 3593 C CD1   . LEU A 1 732 ? 125.761 135.568 114.389 1.00 47.56  ? 726 LEU A CD1   1 
ATOM 3594 C CD2   . LEU A 1 732 ? 128.245 135.310 114.276 1.00 51.69  ? 726 LEU A CD2   1 
ATOM 3595 N N     . GLU A 1 733 ? 127.314 134.804 119.606 1.00 52.63  ? 727 GLU A N     1 
ATOM 3596 C CA    . GLU A 1 733 ? 127.457 135.369 120.942 1.00 53.29  ? 727 GLU A CA    1 
ATOM 3597 C C     . GLU A 1 733 ? 128.684 134.808 121.641 1.00 51.19  ? 727 GLU A C     1 
ATOM 3598 O O     . GLU A 1 733 ? 129.471 135.556 122.232 1.00 60.63  ? 727 GLU A O     1 
ATOM 3599 C CB    . GLU A 1 733 ? 126.197 135.093 121.761 1.00 57.68  ? 727 GLU A CB    1 
ATOM 3600 C CG    . GLU A 1 733 ? 125.530 136.338 122.315 1.00 61.29  ? 727 GLU A CG    1 
ATOM 3601 C CD    . GLU A 1 733 ? 124.065 136.117 122.631 1.00 62.89  ? 727 GLU A CD    1 
ATOM 3602 O OE1   . GLU A 1 733 ? 123.767 135.462 123.652 1.00 61.97  ? 727 GLU A OE1   1 
ATOM 3603 O OE2   . GLU A 1 733 ? 123.210 136.599 121.858 1.00 61.05  ? 727 GLU A OE2   1 
ATOM 3604 N N     . ARG A 1 734 ? 128.875 133.489 121.570 1.00 43.75  ? 728 ARG A N     1 
ATOM 3605 C CA    . ARG A 1 734 ? 130.043 132.880 122.199 1.00 42.94  ? 728 ARG A CA    1 
ATOM 3606 C C     . ARG A 1 734 ? 131.335 133.423 121.598 1.00 46.58  ? 728 ARG A C     1 
ATOM 3607 O O     . ARG A 1 734 ? 132.274 133.780 122.326 1.00 55.81  ? 728 ARG A O     1 
ATOM 3608 C CB    . ARG A 1 734 ? 129.983 131.360 122.060 1.00 44.04  ? 728 ARG A CB    1 
ATOM 3609 C CG    . ARG A 1 734 ? 128.843 130.702 122.821 1.00 54.08  ? 728 ARG A CG    1 
ATOM 3610 C CD    . ARG A 1 734 ? 129.222 130.439 124.268 1.00 52.09  ? 728 ARG A CD    1 
ATOM 3611 N NE    . ARG A 1 734 ? 130.660 130.265 124.430 1.00 57.66  ? 728 ARG A NE    1 
ATOM 3612 C CZ    . ARG A 1 734 ? 131.263 129.093 124.571 1.00 57.37  ? 728 ARG A CZ    1 
ATOM 3613 N NH1   . ARG A 1 734 ? 130.580 127.959 124.570 1.00 53.47  ? 728 ARG A NH1   1 
ATOM 3614 N NH2   . ARG A 1 734 ? 132.585 129.055 124.717 1.00 50.14  ? 728 ARG A NH2   1 
ATOM 3615 N N     . VAL A 1 735 ? 131.395 133.512 120.267 1.00 40.81  ? 729 VAL A N     1 
ATOM 3616 C CA    . VAL A 1 735 ? 132.631 133.933 119.614 1.00 38.98  ? 729 VAL A CA    1 
ATOM 3617 C C     . VAL A 1 735 ? 132.964 135.377 119.969 1.00 39.95  ? 729 VAL A C     1 
ATOM 3618 O O     . VAL A 1 735 ? 134.108 135.694 120.315 1.00 44.38  ? 729 VAL A O     1 
ATOM 3619 C CB    . VAL A 1 735 ? 132.539 133.730 118.092 1.00 39.42  ? 729 VAL A CB    1 
ATOM 3620 C CG1   . VAL A 1 735 ? 133.781 134.281 117.426 1.00 37.72  ? 729 VAL A CG1   1 
ATOM 3621 C CG2   . VAL A 1 735 ? 132.394 132.257 117.768 1.00 41.46  ? 729 VAL A CG2   1 
ATOM 3622 N N     . GLU A 1 736 ? 131.977 136.276 119.896 1.00 40.73  ? 730 GLU A N     1 
ATOM 3623 C CA    . GLU A 1 736 ? 132.260 137.675 120.214 1.00 38.60  ? 730 GLU A CA    1 
ATOM 3624 C C     . GLU A 1 736 ? 132.563 137.873 121.693 1.00 47.84  ? 730 GLU A C     1 
ATOM 3625 O O     . GLU A 1 736 ? 133.398 138.712 122.042 1.00 52.58  ? 730 GLU A O     1 
ATOM 3626 C CB    . GLU A 1 736 ? 131.119 138.592 119.772 1.00 36.05  ? 730 GLU A CB    1 
ATOM 3627 C CG    . GLU A 1 736 ? 130.491 138.237 118.449 1.00 43.46  ? 730 GLU A CG    1 
ATOM 3628 C CD    . GLU A 1 736 ? 129.651 139.360 117.886 1.00 56.20  ? 730 GLU A CD    1 
ATOM 3629 O OE1   . GLU A 1 736 ? 129.241 140.244 118.666 1.00 57.25  ? 730 GLU A OE1   1 
ATOM 3630 O OE2   . GLU A 1 736 ? 129.407 139.365 116.663 1.00 55.04  ? 730 GLU A OE2   1 
ATOM 3631 N N     . GLN A 1 737 ? 131.904 137.124 122.583 1.00 43.62  ? 731 GLN A N     1 
ATOM 3632 C CA    . GLN A 1 737 ? 132.232 137.249 123.998 1.00 35.12  ? 731 GLN A CA    1 
ATOM 3633 C C     . GLN A 1 737 ? 133.670 136.829 124.270 1.00 38.49  ? 731 GLN A C     1 
ATOM 3634 O O     . GLN A 1 737 ? 134.401 137.520 124.989 1.00 50.59  ? 731 GLN A O     1 
ATOM 3635 C CB    . GLN A 1 737 ? 131.265 136.425 124.844 1.00 40.63  ? 731 GLN A CB    1 
ATOM 3636 C CG    . GLN A 1 737 ? 131.550 136.498 126.334 1.00 45.61  ? 731 GLN A CG    1 
ATOM 3637 C CD    . GLN A 1 737 ? 131.516 137.919 126.866 1.00 51.94  ? 731 GLN A CD    1 
ATOM 3638 O OE1   . GLN A 1 737 ? 130.452 138.522 126.991 1.00 56.24  ? 731 GLN A OE1   1 
ATOM 3639 N NE2   . GLN A 1 737 ? 132.687 138.459 127.183 1.00 48.43  ? 731 GLN A NE2   1 
ATOM 3640 N N     . GLU A 1 738 ? 134.103 135.706 123.690 1.00 30.25  ? 732 GLU A N     1 
ATOM 3641 C CA    . GLU A 1 738 ? 135.486 135.283 123.888 1.00 36.26  ? 732 GLU A CA    1 
ATOM 3642 C C     . GLU A 1 738 ? 136.468 136.271 123.265 1.00 46.62  ? 732 GLU A C     1 
ATOM 3643 O O     . GLU A 1 738 ? 137.511 136.577 123.859 1.00 54.05  ? 732 GLU A O     1 
ATOM 3644 C CB    . GLU A 1 738 ? 135.695 133.881 123.323 1.00 36.68  ? 732 GLU A CB    1 
ATOM 3645 C CG    . GLU A 1 738 ? 136.757 133.078 124.055 1.00 46.41  ? 732 GLU A CG    1 
ATOM 3646 C CD    . GLU A 1 738 ? 136.255 132.490 125.361 1.00 55.90  ? 732 GLU A CD    1 
ATOM 3647 O OE1   . GLU A 1 738 ? 135.054 132.645 125.665 1.00 59.05  ? 732 GLU A OE1   1 
ATOM 3648 O OE2   . GLU A 1 738 ? 137.064 131.876 126.088 1.00 56.03  ? 732 GLU A OE2   1 
ATOM 3649 N N     . LEU A 1 739 ? 136.151 136.786 122.073 1.00 36.24  ? 733 LEU A N     1 
ATOM 3650 C CA    . LEU A 1 739 ? 137.022 137.770 121.439 1.00 23.37  ? 733 LEU A CA    1 
ATOM 3651 C C     . LEU A 1 739 ? 137.146 139.026 122.291 1.00 27.21  ? 733 LEU A C     1 
ATOM 3652 O O     . LEU A 1 739 ? 138.241 139.579 122.441 1.00 42.08  ? 733 LEU A O     1 
ATOM 3653 C CB    . LEU A 1 739 ? 136.494 138.118 120.047 1.00 34.73  ? 733 LEU A CB    1 
ATOM 3654 C CG    . LEU A 1 739 ? 136.801 137.145 118.910 1.00 35.97  ? 733 LEU A CG    1 
ATOM 3655 C CD1   . LEU A 1 739 ? 136.133 137.601 117.630 1.00 24.28  ? 733 LEU A CD1   1 
ATOM 3656 C CD2   . LEU A 1 739 ? 138.296 137.012 118.709 1.00 39.45  ? 733 LEU A CD2   1 
ATOM 3657 N N     . LYS A 1 740 ? 136.032 139.493 122.856 1.00 30.77  ? 734 LYS A N     1 
ATOM 3658 C CA    . LYS A 1 740 ? 136.071 140.649 123.743 1.00 34.15  ? 734 LYS A CA    1 
ATOM 3659 C C     . LYS A 1 740 ? 136.909 140.361 124.979 1.00 36.78  ? 734 LYS A C     1 
ATOM 3660 O O     . LYS A 1 740 ? 137.682 141.215 125.427 1.00 41.20  ? 734 LYS A O     1 
ATOM 3661 C CB    . LYS A 1 740 ? 134.651 141.051 124.138 1.00 40.32  ? 734 LYS A CB    1 
ATOM 3662 C CG    . LYS A 1 740 ? 134.514 142.480 124.619 1.00 42.35  ? 734 LYS A CG    1 
ATOM 3663 C CD    . LYS A 1 740 ? 133.071 142.792 124.973 1.00 42.40  ? 734 LYS A CD    1 
ATOM 3664 C CE    . LYS A 1 740 ? 132.963 144.063 125.798 1.00 43.75  ? 734 LYS A CE    1 
ATOM 3665 N NZ    . LYS A 1 740 ? 132.387 145.187 125.009 1.00 40.64  ? 734 LYS A NZ    1 
ATOM 3666 N N     . ASN A 1 741 ? 136.765 139.161 125.550 1.00 37.93  ? 735 ASN A N     1 
ATOM 3667 C CA    . ASN A 1 741 ? 137.601 138.784 126.684 1.00 39.68  ? 735 ASN A CA    1 
ATOM 3668 C C     . ASN A 1 741 ? 139.078 138.795 126.316 1.00 42.58  ? 735 ASN A C     1 
ATOM 3669 O O     . ASN A 1 741 ? 139.927 139.068 127.169 1.00 46.97  ? 735 ASN A O     1 
ATOM 3670 C CB    . ASN A 1 741 ? 137.195 137.407 127.209 1.00 35.71  ? 735 ASN A CB    1 
ATOM 3671 C CG    . ASN A 1 741 ? 135.843 137.420 127.882 1.00 39.72  ? 735 ASN A CG    1 
ATOM 3672 O OD1   . ASN A 1 741 ? 135.205 138.464 127.996 1.00 38.66  ? 735 ASN A OD1   1 
ATOM 3673 N ND2   . ASN A 1 741 ? 135.397 136.255 128.335 1.00 39.99  ? 735 ASN A ND2   1 
ATOM 3674 N N     . GLU A 1 742 ? 139.401 138.500 125.060 1.00 41.67  ? 736 GLU A N     1 
ATOM 3675 C CA    . GLU A 1 742 ? 140.777 138.590 124.590 1.00 33.22  ? 736 GLU A CA    1 
ATOM 3676 C C     . GLU A 1 742 ? 141.139 139.977 124.071 1.00 37.45  ? 736 GLU A C     1 
ATOM 3677 O O     . GLU A 1 742 ? 142.263 140.170 123.597 1.00 44.69  ? 736 GLU A O     1 
ATOM 3678 C CB    . GLU A 1 742 ? 141.035 137.548 123.499 1.00 37.16  ? 736 GLU A CB    1 
ATOM 3679 C CG    . GLU A 1 742 ? 141.269 136.145 124.031 1.00 45.56  ? 736 GLU A CG    1 
ATOM 3680 C CD    . GLU A 1 742 ? 142.560 136.021 124.819 1.00 51.93  ? 736 GLU A CD    1 
ATOM 3681 O OE1   . GLU A 1 742 ? 143.485 136.828 124.586 1.00 49.59  ? 736 GLU A OE1   1 
ATOM 3682 O OE2   . GLU A 1 742 ? 142.654 135.110 125.669 1.00 54.87  ? 736 GLU A OE2   1 
ATOM 3683 N N     . GLY A 1 743 ? 140.224 140.938 124.147 1.00 33.85  ? 737 GLY A N     1 
ATOM 3684 C CA    . GLY A 1 743 ? 140.516 142.290 123.708 1.00 34.42  ? 737 GLY A CA    1 
ATOM 3685 C C     . GLY A 1 743 ? 140.397 142.524 122.220 1.00 35.34  ? 737 GLY A C     1 
ATOM 3686 O O     . GLY A 1 743 ? 141.155 143.327 121.660 1.00 37.59  ? 737 GLY A O     1 
ATOM 3687 N N     . ILE A 1 744 ? 139.468 141.841 121.555 1.00 37.04  ? 738 ILE A N     1 
ATOM 3688 C CA    . ILE A 1 744 ? 139.255 141.974 120.118 1.00 20.18  ? 738 ILE A CA    1 
ATOM 3689 C C     . ILE A 1 744 ? 137.786 142.293 119.884 1.00 32.12  ? 738 ILE A C     1 
ATOM 3690 O O     . ILE A 1 744 ? 136.907 141.548 120.333 1.00 48.85  ? 738 ILE A O     1 
ATOM 3691 C CB    . ILE A 1 744 ? 139.658 140.701 119.357 1.00 16.89  ? 738 ILE A CB    1 
ATOM 3692 C CG1   . ILE A 1 744 ? 141.129 140.372 119.599 1.00 20.71  ? 738 ILE A CG1   1 
ATOM 3693 C CG2   . ILE A 1 744 ? 139.395 140.866 117.876 1.00 34.62  ? 738 ILE A CG2   1 
ATOM 3694 C CD1   . ILE A 1 744 ? 141.521 138.992 119.137 1.00 22.56  ? 738 ILE A CD1   1 
ATOM 3695 N N     . LEU A 1 745 ? 137.518 143.390 119.182 1.00 32.58  ? 739 LEU A N     1 
ATOM 3696 C CA    . LEU A 1 745 ? 136.149 143.779 118.880 1.00 27.46  ? 739 LEU A CA    1 
ATOM 3697 C C     . LEU A 1 745 ? 135.685 143.133 117.581 1.00 30.55  ? 739 LEU A C     1 
ATOM 3698 O O     . LEU A 1 745 ? 136.429 143.074 116.599 1.00 48.15  ? 739 LEU A O     1 
ATOM 3699 C CB    . LEU A 1 745 ? 136.035 145.299 118.778 1.00 27.80  ? 739 LEU A CB    1 
ATOM 3700 C CG    . LEU A 1 745 ? 136.072 146.073 120.097 1.00 38.57  ? 739 LEU A CG    1 
ATOM 3701 C CD1   . LEU A 1 745 ? 135.509 147.469 119.904 1.00 41.47  ? 739 LEU A CD1   1 
ATOM 3702 C CD2   . LEU A 1 745 ? 135.317 145.332 121.188 1.00 35.93  ? 739 LEU A CD2   1 
ATOM 3703 N N     . ALA A 1 746 ? 134.443 142.655 117.577 1.00 27.52  ? 740 ALA A N     1 
ATOM 3704 C CA    . ALA A 1 746 ? 133.890 141.941 116.438 1.00 33.21  ? 740 ALA A CA    1 
ATOM 3705 C C     . ALA A 1 746 ? 132.579 142.580 116.002 1.00 36.67  ? 740 ALA A C     1 
ATOM 3706 O O     . ALA A 1 746 ? 131.795 143.061 116.826 1.00 43.86  ? 740 ALA A O     1 
ATOM 3707 C CB    . ALA A 1 746 ? 133.662 140.461 116.762 1.00 37.45  ? 740 ALA A CB    1 
ATOM 3708 N N     . TRP A 1 747 ? 132.353 142.577 114.692 1.00 31.07  ? 741 TRP A N     1 
ATOM 3709 C CA    . TRP A 1 747 ? 131.145 143.118 114.091 1.00 29.49  ? 741 TRP A CA    1 
ATOM 3710 C C     . TRP A 1 747 ? 130.578 142.124 113.090 1.00 42.03  ? 741 TRP A C     1 
ATOM 3711 O O     . TRP A 1 747 ? 131.327 141.487 112.342 1.00 55.60  ? 741 TRP A O     1 
ATOM 3712 C CB    . TRP A 1 747 ? 131.423 144.459 113.402 1.00 35.02  ? 741 TRP A CB    1 
ATOM 3713 C CG    . TRP A 1 747 ? 130.195 145.149 112.890 1.00 41.57  ? 741 TRP A CG    1 
ATOM 3714 C CD1   . TRP A 1 747 ? 129.901 145.438 111.591 1.00 44.26  ? 741 TRP A CD1   1 
ATOM 3715 C CD2   . TRP A 1 747 ? 129.099 145.642 113.668 1.00 37.55  ? 741 TRP A CD2   1 
ATOM 3716 N NE1   . TRP A 1 747 ? 128.689 146.076 111.509 1.00 43.02  ? 741 TRP A NE1   1 
ATOM 3717 C CE2   . TRP A 1 747 ? 128.176 146.214 112.771 1.00 38.06  ? 741 TRP A CE2   1 
ATOM 3718 C CE3   . TRP A 1 747 ? 128.806 145.654 115.034 1.00 45.61  ? 741 TRP A CE3   1 
ATOM 3719 C CZ2   . TRP A 1 747 ? 126.984 146.789 113.196 1.00 43.93  ? 741 TRP A CZ2   1 
ATOM 3720 C CZ3   . TRP A 1 747 ? 127.623 146.226 115.453 1.00 48.49  ? 741 TRP A CZ3   1 
ATOM 3721 C CH2   . TRP A 1 747 ? 126.725 146.786 114.537 1.00 45.56  ? 741 TRP A CH2   1 
ATOM 3722 N N     . GLU A 1 748 ? 129.251 142.006 113.069 1.00 40.61  ? 742 GLU A N     1 
ATOM 3723 C CA    . GLU A 1 748 ? 128.561 141.109 112.150 1.00 36.67  ? 742 GLU A CA    1 
ATOM 3724 C C     . GLU A 1 748 ? 128.187 141.873 110.887 1.00 38.71  ? 742 GLU A C     1 
ATOM 3725 O O     . GLU A 1 748 ? 127.476 142.881 110.952 1.00 43.03  ? 742 GLU A O     1 
ATOM 3726 C CB    . GLU A 1 748 ? 127.310 140.520 112.800 1.00 39.38  ? 742 GLU A CB    1 
ATOM 3727 C CG    . GLU A 1 748 ? 127.574 139.654 114.015 1.00 48.08  ? 742 GLU A CG    1 
ATOM 3728 C CD    . GLU A 1 748 ? 126.370 139.559 114.932 1.00 54.57  ? 742 GLU A CD    1 
ATOM 3729 O OE1   . GLU A 1 748 ? 126.549 139.226 116.122 1.00 54.04  ? 742 GLU A OE1   1 
ATOM 3730 O OE2   . GLU A 1 748 ? 125.241 139.817 114.463 1.00 52.79  ? 742 GLU A OE2   1 
ATOM 3731 N N     . VAL A 1 749 ? 128.655 141.387 109.745 1.00 34.33  ? 743 VAL A N     1 
ATOM 3732 C CA    . VAL A 1 749 ? 128.408 142.010 108.451 1.00 29.13  ? 743 VAL A CA    1 
ATOM 3733 C C     . VAL A 1 749 ? 127.279 141.262 107.761 1.00 32.77  ? 743 VAL A C     1 
ATOM 3734 O O     . VAL A 1 749 ? 127.072 140.064 107.988 1.00 34.99  ? 743 VAL A O     1 
ATOM 3735 C CB    . VAL A 1 749 ? 129.694 142.012 107.597 1.00 26.78  ? 743 VAL A CB    1 
ATOM 3736 C CG1   . VAL A 1 749 ? 129.528 142.888 106.377 1.00 36.25  ? 743 VAL A CG1   1 
ATOM 3737 C CG2   . VAL A 1 749 ? 130.876 142.473 108.427 1.00 27.88  ? 743 VAL A CG2   1 
ATOM 3738 N N     . ASP A 1 750 ? 126.541 141.969 106.916 1.00 44.83  ? 744 ASP A N     1 
ATOM 3739 C CA    . ASP A 1 750 ? 125.430 141.363 106.190 1.00 43.07  ? 744 ASP A CA    1 
ATOM 3740 C C     . ASP A 1 750 ? 125.967 140.360 105.179 1.00 42.36  ? 744 ASP A C     1 
ATOM 3741 O O     . ASP A 1 750 ? 126.714 140.747 104.272 1.00 40.54  ? 744 ASP A O     1 
ATOM 3742 C CB    . ASP A 1 750 ? 124.611 142.447 105.497 1.00 37.46  ? 744 ASP A CB    1 
ATOM 3743 C CG    . ASP A 1 750 ? 123.450 141.887 104.702 1.00 46.39  ? 744 ASP A CG    1 
ATOM 3744 O OD1   . ASP A 1 750 ? 122.839 140.899 105.157 1.00 54.47  ? 744 ASP A OD1   1 
ATOM 3745 O OD2   . ASP A 1 750 ? 123.147 142.435 103.623 1.00 42.51  ? 744 ASP A OD2   1 
ATOM 3746 N N     . PRO A 1 751 ? 125.626 139.067 105.293 1.00 39.78  ? 745 PRO A N     1 
ATOM 3747 C CA    . PRO A 1 751 ? 126.211 138.034 104.431 1.00 38.70  ? 745 PRO A CA    1 
ATOM 3748 C C     . PRO A 1 751 ? 125.384 137.734 103.184 1.00 44.65  ? 745 PRO A C     1 
ATOM 3749 O O     . PRO A 1 751 ? 125.040 136.582 102.904 1.00 59.80  ? 745 PRO A O     1 
ATOM 3750 C CB    . PRO A 1 751 ? 126.269 136.821 105.363 1.00 46.06  ? 745 PRO A CB    1 
ATOM 3751 C CG    . PRO A 1 751 ? 125.038 136.983 106.203 1.00 43.55  ? 745 PRO A CG    1 
ATOM 3752 C CD    . PRO A 1 751 ? 124.748 138.474 106.315 1.00 40.84  ? 745 PRO A CD    1 
ATOM 3753 N N     . ARG A 1 752 ? 125.064 138.769 102.416 1.00 36.29  ? 746 ARG A N     1 
ATOM 3754 C CA    . ARG A 1 752 ? 124.249 138.618 101.220 1.00 37.86  ? 746 ARG A CA    1 
ATOM 3755 C C     . ARG A 1 752 ? 125.141 138.679 99.989  1.00 33.82  ? 746 ARG A C     1 
ATOM 3756 O O     . ARG A 1 752 ? 125.902 139.636 99.815  1.00 41.34  ? 746 ARG A O     1 
ATOM 3757 C CB    . ARG A 1 752 ? 123.169 139.697 101.147 1.00 42.59  ? 746 ARG A CB    1 
ATOM 3758 C CG    . ARG A 1 752 ? 122.222 139.536 99.970  1.00 47.28  ? 746 ARG A CG    1 
ATOM 3759 C CD    . ARG A 1 752 ? 121.707 140.882 99.471  1.00 48.13  ? 746 ARG A CD    1 
ATOM 3760 N NE    . ARG A 1 752 ? 120.623 141.430 100.282 1.00 54.23  ? 746 ARG A NE    1 
ATOM 3761 C CZ    . ARG A 1 752 ? 119.454 140.842 100.497 1.00 53.41  ? 746 ARG A CZ    1 
ATOM 3762 N NH1   . ARG A 1 752 ? 119.149 139.678 99.947  1.00 45.39  ? 746 ARG A NH1   1 
ATOM 3763 N NH2   . ARG A 1 752 ? 118.558 141.446 101.273 1.00 55.33  ? 746 ARG A NH2   1 
ATOM 3764 N N     . HIS A 1 753 ? 125.049 137.650 99.146  1.00 37.06  ? 747 HIS A N     1 
ATOM 3765 C CA    . HIS A 1 753 ? 125.795 137.549 97.894  1.00 42.36  ? 747 HIS A CA    1 
ATOM 3766 C C     . HIS A 1 753 ? 127.302 137.533 98.106  1.00 44.50  ? 747 HIS A C     1 
ATOM 3767 O O     . HIS A 1 753 ? 128.062 137.863 97.192  1.00 53.77  ? 747 HIS A O     1 
ATOM 3768 C CB    . HIS A 1 753 ? 125.415 138.679 96.929  1.00 50.57  ? 747 HIS A CB    1 
ATOM 3769 C CG    . HIS A 1 753 ? 123.991 138.630 96.470  1.00 49.25  ? 747 HIS A CG    1 
ATOM 3770 N ND1   . HIS A 1 753 ? 123.442 137.522 95.862  1.00 45.96  ? 747 HIS A ND1   1 
ATOM 3771 C CD2   . HIS A 1 753 ? 123.002 139.552 96.534  1.00 46.99  ? 747 HIS A CD2   1 
ATOM 3772 C CE1   . HIS A 1 753 ? 122.178 137.763 95.571  1.00 44.09  ? 747 HIS A CE1   1 
ATOM 3773 N NE2   . HIS A 1 753 ? 121.885 138.988 95.969  1.00 44.48  ? 747 HIS A NE2   1 
ATOM 3774 N N     . THR A 1 754 ? 127.761 137.152 99.299  1.00 43.42  ? 748 THR A N     1 
ATOM 3775 C CA    . THR A 1 754 ? 129.196 137.071 99.545  1.00 40.94  ? 748 THR A CA    1 
ATOM 3776 C C     . THR A 1 754 ? 129.820 135.848 98.892  1.00 40.30  ? 748 THR A C     1 
ATOM 3777 O O     . THR A 1 754 ? 130.961 135.917 98.423  1.00 45.94  ? 748 THR A O     1 
ATOM 3778 C CB    . THR A 1 754 ? 129.478 137.055 101.046 1.00 42.05  ? 748 THR A CB    1 
ATOM 3779 O OG1   . THR A 1 754 ? 129.141 135.769 101.581 1.00 49.40  ? 748 THR A OG1   1 
ATOM 3780 C CG2   . THR A 1 754 ? 128.665 138.121 101.749 1.00 48.94  ? 748 THR A CG2   1 
ATOM 3781 N N     . SER A 1 755 ? 129.100 134.732 98.854  1.00 43.75  ? 749 SER A N     1 
ATOM 3782 C CA    . SER A 1 755 ? 129.597 133.507 98.245  1.00 48.03  ? 749 SER A CA    1 
ATOM 3783 C C     . SER A 1 755 ? 129.319 133.433 96.750  1.00 52.04  ? 749 SER A C     1 
ATOM 3784 O O     . SER A 1 755 ? 129.748 132.472 96.103  1.00 55.32  ? 749 SER A O     1 
ATOM 3785 C CB    . SER A 1 755 ? 128.988 132.288 98.945  1.00 48.43  ? 749 SER A CB    1 
ATOM 3786 O OG    . SER A 1 755 ? 127.613 132.493 99.216  1.00 51.95  ? 749 SER A OG    1 
ATOM 3787 N N     . GLN A 1 756 ? 128.620 134.419 96.188  1.00 53.29  ? 750 GLN A N     1 
ATOM 3788 C CA    . GLN A 1 756 ? 128.300 134.433 94.769  1.00 49.67  ? 750 GLN A CA    1 
ATOM 3789 C C     . GLN A 1 756 ? 128.956 135.573 94.006  1.00 50.92  ? 750 GLN A C     1 
ATOM 3790 O O     . GLN A 1 756 ? 128.886 135.589 92.773  1.00 51.56  ? 750 GLN A O     1 
ATOM 3791 C CB    . GLN A 1 756 ? 126.780 134.510 94.570  1.00 45.09  ? 750 GLN A CB    1 
ATOM 3792 C CG    . GLN A 1 756 ? 125.982 133.719 95.585  1.00 45.95  ? 750 GLN A CG    1 
ATOM 3793 C CD    . GLN A 1 756 ? 124.491 133.941 95.447  1.00 57.59  ? 750 GLN A CD    1 
ATOM 3794 O OE1   . GLN A 1 756 ? 124.052 134.933 94.867  1.00 57.55  ? 750 GLN A OE1   1 
ATOM 3795 N NE2   . GLN A 1 756 ? 123.703 133.015 95.980  1.00 58.07  ? 750 GLN A NE2   1 
ATOM 3796 N N     . THR A 1 757 ? 129.587 136.521 94.693  1.00 48.15  ? 751 THR A N     1 
ATOM 3797 C CA    . THR A 1 757 ? 130.207 137.677 94.064  1.00 42.49  ? 751 THR A CA    1 
ATOM 3798 C C     . THR A 1 757 ? 131.721 137.586 94.191  1.00 43.40  ? 751 THR A C     1 
ATOM 3799 O O     . THR A 1 757 ? 132.245 137.235 95.252  1.00 40.24  ? 751 THR A O     1 
ATOM 3800 C CB    . THR A 1 757 ? 129.715 138.982 94.698  1.00 44.32  ? 751 THR A CB    1 
ATOM 3801 O OG1   . THR A 1 757 ? 128.292 138.936 94.848  1.00 50.44  ? 751 THR A OG1   1 
ATOM 3802 C CG2   . THR A 1 757 ? 130.082 140.169 93.830  1.00 46.25  ? 751 THR A CG2   1 
ATOM 3803 N N     . SER A 1 758 ? 132.419 137.898 93.102  1.00 46.87  ? 752 SER A N     1 
ATOM 3804 C CA    . SER A 1 758 ? 133.873 137.866 93.113  1.00 47.11  ? 752 SER A CA    1 
ATOM 3805 C C     . SER A 1 758 ? 134.425 138.991 93.977  1.00 45.92  ? 752 SER A C     1 
ATOM 3806 O O     . SER A 1 758 ? 133.851 140.080 94.047  1.00 56.47  ? 752 SER A O     1 
ATOM 3807 C CB    . SER A 1 758 ? 134.418 137.982 91.691  1.00 46.00  ? 752 SER A CB    1 
ATOM 3808 O OG    . SER A 1 758 ? 134.767 139.322 91.396  1.00 49.93  ? 752 SER A OG    1 
ATOM 3809 N N     . CYS A 1 759 ? 135.544 138.720 94.641  1.00 43.36  ? 753 CYS A N     1 
ATOM 3810 C CA    . CYS A 1 759 ? 136.186 139.693 95.511  1.00 41.61  ? 753 CYS A CA    1 
ATOM 3811 C C     . CYS A 1 759 ? 137.193 140.570 94.778  1.00 48.43  ? 753 CYS A C     1 
ATOM 3812 O O     . CYS A 1 759 ? 137.843 141.405 95.415  1.00 53.83  ? 753 CYS A O     1 
ATOM 3813 C CB    . CYS A 1 759 ? 136.878 138.983 96.679  1.00 40.90  ? 753 CYS A CB    1 
ATOM 3814 S SG    . CYS A 1 759 ? 137.997 137.656 96.188  1.00 51.59  ? 753 CYS A SG    1 
ATOM 3815 N N     . ILE A 1 760 ? 137.341 140.400 93.469  1.00 46.57  ? 754 ILE A N     1 
ATOM 3816 C CA    . ILE A 1 760 ? 138.271 141.184 92.667  1.00 44.83  ? 754 ILE A CA    1 
ATOM 3817 C C     . ILE A 1 760 ? 137.534 142.123 91.722  1.00 51.79  ? 754 ILE A C     1 
ATOM 3818 O O     . ILE A 1 760 ? 137.752 143.335 91.742  1.00 60.36  ? 754 ILE A O     1 
ATOM 3819 C CB    . ILE A 1 760 ? 139.239 140.266 91.889  1.00 50.93  ? 754 ILE A CB    1 
ATOM 3820 C CG1   . ILE A 1 760 ? 139.638 139.066 92.746  1.00 48.62  ? 754 ILE A CG1   1 
ATOM 3821 C CG2   . ILE A 1 760 ? 140.464 141.045 91.443  1.00 52.60  ? 754 ILE A CG2   1 
ATOM 3822 C CD1   . ILE A 1 760 ? 140.827 138.309 92.210  1.00 50.88  ? 754 ILE A CD1   1 
ATOM 3823 N N     . THR A 1 761 ? 136.655 141.577 90.883  1.00 54.74  ? 755 THR A N     1 
ATOM 3824 C CA    . THR A 1 761 ? 135.872 142.393 89.967  1.00 57.00  ? 755 THR A CA    1 
ATOM 3825 C C     . THR A 1 761 ? 134.643 143.002 90.621  1.00 52.21  ? 755 THR A C     1 
ATOM 3826 O O     . THR A 1 761 ? 134.051 143.921 90.047  1.00 55.69  ? 755 THR A O     1 
ATOM 3827 C CB    . THR A 1 761 ? 135.439 141.562 88.758  1.00 56.05  ? 755 THR A CB    1 
ATOM 3828 O OG1   . THR A 1 761 ? 134.431 140.624 89.157  1.00 58.38  ? 755 THR A OG1   1 
ATOM 3829 C CG2   . THR A 1 761 ? 136.627 140.812 88.175  1.00 53.97  ? 755 THR A CG2   1 
ATOM 3830 N N     . ASP A 1 762 ? 134.266 142.523 91.804  1.00 47.18  ? 756 ASP A N     1 
ATOM 3831 C CA    . ASP A 1 762 ? 133.045 142.936 92.491  1.00 49.93  ? 756 ASP A CA    1 
ATOM 3832 C C     . ASP A 1 762 ? 131.865 142.762 91.528  1.00 54.20  ? 756 ASP A C     1 
ATOM 3833 O O     . ASP A 1 762 ? 131.174 143.704 91.138  1.00 57.46  ? 756 ASP A O     1 
ATOM 3834 C CB    . ASP A 1 762 ? 133.199 144.368 93.029  1.00 58.11  ? 756 ASP A CB    1 
ATOM 3835 C CG    . ASP A 1 762 ? 131.880 145.028 93.412  1.00 66.54  ? 756 ASP A CG    1 
ATOM 3836 O OD1   . ASP A 1 762 ? 131.861 146.272 93.520  1.00 63.31  ? 756 ASP A OD1   1 
ATOM 3837 O OD2   . ASP A 1 762 ? 130.886 144.317 93.677  1.00 64.71  ? 756 ASP A OD2   1 
ATOM 3838 N N     . GLU A 1 763 ? 131.699 141.517 91.088  1.00 59.35  ? 757 GLU A N     1 
ATOM 3839 C CA    . GLU A 1 763 ? 130.665 141.141 90.134  1.00 55.46  ? 757 GLU A CA    1 
ATOM 3840 C C     . GLU A 1 763 ? 130.290 139.688 90.374  1.00 56.79  ? 757 GLU A C     1 
ATOM 3841 O O     . GLU A 1 763 ? 131.039 138.930 90.993  1.00 57.33  ? 757 GLU A O     1 
ATOM 3842 C CB    . GLU A 1 763 ? 131.124 141.332 88.684  1.00 51.88  ? 757 GLU A CB    1 
ATOM 3843 C CG    . GLU A 1 763 ? 130.910 142.728 88.136  1.00 57.98  ? 757 GLU A CG    1 
ATOM 3844 C CD    . GLU A 1 763 ? 131.794 143.023 86.941  1.00 65.96  ? 757 GLU A CD    1 
ATOM 3845 O OE1   . GLU A 1 763 ? 131.918 142.150 86.058  1.00 68.59  ? 757 GLU A OE1   1 
ATOM 3846 O OE2   . GLU A 1 763 ? 132.373 144.127 86.890  1.00 64.82  ? 757 GLU A OE2   1 
ATOM 3847 N N     . PHE A 1 764 ? 129.121 139.308 89.871  1.00 51.85  ? 758 PHE A N     1 
ATOM 3848 C CA    . PHE A 1 764 ? 128.632 137.953 90.074  1.00 48.35  ? 758 PHE A CA    1 
ATOM 3849 C C     . PHE A 1 764 ? 129.477 136.947 89.302  1.00 52.24  ? 758 PHE A C     1 
ATOM 3850 O O     . PHE A 1 764 ? 129.901 137.199 88.172  1.00 53.34  ? 758 PHE A O     1 
ATOM 3851 C CB    . PHE A 1 764 ? 127.170 137.848 89.650  1.00 45.40  ? 758 PHE A CB    1 
ATOM 3852 C CG    . PHE A 1 764 ? 126.212 138.425 90.647  1.00 40.91  ? 758 PHE A CG    1 
ATOM 3853 C CD1   . PHE A 1 764 ? 125.894 139.768 90.620  1.00 47.03  ? 758 PHE A CD1   1 
ATOM 3854 C CD2   . PHE A 1 764 ? 125.632 137.624 91.612  1.00 48.37  ? 758 PHE A CD2   1 
ATOM 3855 C CE1   . PHE A 1 764 ? 125.012 140.300 91.537  1.00 50.35  ? 758 PHE A CE1   1 
ATOM 3856 C CE2   . PHE A 1 764 ? 124.750 138.153 92.530  1.00 50.29  ? 758 PHE A CE2   1 
ATOM 3857 C CZ    . PHE A 1 764 ? 124.440 139.492 92.492  1.00 46.34  ? 758 PHE A CZ    1 
ATOM 3858 N N     . GLY A 1 765 ? 129.724 135.801 89.929  1.00 53.39  ? 759 GLY A N     1 
ATOM 3859 C CA    . GLY A 1 765 ? 130.438 134.712 89.296  1.00 41.97  ? 759 GLY A CA    1 
ATOM 3860 C C     . GLY A 1 765 ? 129.672 133.413 89.421  1.00 47.56  ? 759 GLY A C     1 
ATOM 3861 O O     . GLY A 1 765 ? 128.467 133.428 89.687  1.00 48.10  ? 759 GLY A O     1 
ATOM 3862 N N     . TYR A 1 766 ? 130.351 132.283 89.238  1.00 58.51  ? 760 TYR A N     1 
ATOM 3863 C CA    . TYR A 1 766 ? 129.724 130.970 89.346  1.00 59.12  ? 760 TYR A CA    1 
ATOM 3864 C C     . TYR A 1 766 ? 130.295 130.243 90.555  1.00 59.43  ? 760 TYR A C     1 
ATOM 3865 O O     . TYR A 1 766 ? 131.514 130.078 90.667  1.00 61.10  ? 760 TYR A O     1 
ATOM 3866 C CB    . TYR A 1 766 ? 129.933 130.147 88.077  1.00 55.06  ? 760 TYR A CB    1 
ATOM 3867 C CG    . TYR A 1 766 ? 129.211 128.822 88.110  1.00 57.24  ? 760 TYR A CG    1 
ATOM 3868 C CD1   . TYR A 1 766 ? 127.932 128.724 88.641  1.00 56.82  ? 760 TYR A CD1   1 
ATOM 3869 C CD2   . TYR A 1 766 ? 129.812 127.668 87.636  1.00 59.33  ? 760 TYR A CD2   1 
ATOM 3870 C CE1   . TYR A 1 766 ? 127.267 127.518 88.683  1.00 53.29  ? 760 TYR A CE1   1 
ATOM 3871 C CE2   . TYR A 1 766 ? 129.157 126.455 87.676  1.00 60.76  ? 760 TYR A CE2   1 
ATOM 3872 C CZ    . TYR A 1 766 ? 127.884 126.387 88.199  1.00 60.08  ? 760 TYR A CZ    1 
ATOM 3873 O OH    . TYR A 1 766 ? 127.223 125.182 88.243  1.00 62.45  ? 760 TYR A OH    1 
ATOM 3874 N N     . ARG A 1 767 ? 129.415 129.813 91.455  1.00 55.21  ? 761 ARG A N     1 
ATOM 3875 C CA    . ARG A 1 767 ? 129.791 128.950 92.571  1.00 55.56  ? 761 ARG A CA    1 
ATOM 3876 C C     . ARG A 1 767 ? 129.457 127.515 92.187  1.00 62.86  ? 761 ARG A C     1 
ATOM 3877 O O     . ARG A 1 767 ? 128.281 127.143 92.112  1.00 65.93  ? 761 ARG A O     1 
ATOM 3878 C CB    . ARG A 1 767 ? 129.063 129.365 93.847  1.00 51.09  ? 761 ARG A CB    1 
ATOM 3879 C CG    . ARG A 1 767 ? 129.205 128.369 94.984  1.00 55.43  ? 761 ARG A CG    1 
ATOM 3880 C CD    . ARG A 1 767 ? 130.328 128.766 95.919  1.00 60.43  ? 761 ARG A CD    1 
ATOM 3881 N NE    . ARG A 1 767 ? 130.457 127.861 97.054  1.00 59.63  ? 761 ARG A NE    1 
ATOM 3882 C CZ    . ARG A 1 767 ? 129.634 127.835 98.093  1.00 60.04  ? 761 ARG A CZ    1 
ATOM 3883 N NH1   . ARG A 1 767 ? 128.601 128.656 98.176  1.00 61.63  ? 761 ARG A NH1   1 
ATOM 3884 N NH2   . ARG A 1 767 ? 129.857 126.969 99.076  1.00 58.85  ? 761 ARG A NH2   1 
ATOM 3885 N N     . SER A 1 768 ? 130.491 126.712 91.943  1.00 57.35  ? 762 SER A N     1 
ATOM 3886 C CA    . SER A 1 768 ? 130.286 125.365 91.428  1.00 59.48  ? 762 SER A CA    1 
ATOM 3887 C C     . SER A 1 768 ? 129.504 124.513 92.419  1.00 59.73  ? 762 SER A C     1 
ATOM 3888 O O     . SER A 1 768 ? 129.776 124.518 93.623  1.00 62.00  ? 762 SER A O     1 
ATOM 3889 C CB    . SER A 1 768 ? 131.631 124.711 91.116  1.00 59.56  ? 762 SER A CB    1 
ATOM 3890 O OG    . SER A 1 768 ? 131.555 123.305 91.263  1.00 61.96  ? 762 SER A OG    1 
ATOM 3891 N N     . LEU A 1 769 ? 128.521 123.778 91.901  1.00 68.46  ? 763 LEU A N     1 
ATOM 3892 C CA    . LEU A 1 769 ? 127.677 122.920 92.724  1.00 71.62  ? 763 LEU A CA    1 
ATOM 3893 C C     . LEU A 1 769 ? 128.226 121.502 92.837  1.00 72.85  ? 763 LEU A C     1 
ATOM 3894 O O     . LEU A 1 769 ? 128.009 120.835 93.854  1.00 72.44  ? 763 LEU A O     1 
ATOM 3895 C CB    . LEU A 1 769 ? 126.255 122.893 92.158  1.00 70.52  ? 763 LEU A CB    1 
ATOM 3896 C CG    . LEU A 1 769 ? 126.119 122.651 90.653  1.00 72.23  ? 763 LEU A CG    1 
ATOM 3897 C CD1   . LEU A 1 769 ? 125.889 121.178 90.348  1.00 70.72  ? 763 LEU A CD1   1 
ATOM 3898 C CD2   . LEU A 1 769 ? 125.000 123.503 90.078  1.00 72.06  ? 763 LEU A CD2   1 
ATOM 3899 N N     . VAL A 1 770 ? 128.925 121.024 91.806  1.00 72.09  ? 764 VAL A N     1 
ATOM 3900 C CA    . VAL A 1 770 ? 129.556 119.707 91.879  1.00 69.71  ? 764 VAL A CA    1 
ATOM 3901 C C     . VAL A 1 770 ? 130.647 119.705 92.945  1.00 71.18  ? 764 VAL A C     1 
ATOM 3902 O O     . VAL A 1 770 ? 130.767 118.764 93.738  1.00 70.23  ? 764 VAL A O     1 
ATOM 3903 C CB    . VAL A 1 770 ? 130.094 119.286 90.498  1.00 68.04  ? 764 VAL A CB    1 
ATOM 3904 C CG1   . VAL A 1 770 ? 131.017 120.346 89.918  1.00 67.78  ? 764 VAL A CG1   1 
ATOM 3905 C CG2   . VAL A 1 770 ? 130.809 117.948 90.591  1.00 65.68  ? 764 VAL A CG2   1 
ATOM 3906 N N     . ALA A 1 771 ? 131.452 120.766 92.983  1.00 66.87  ? 765 ALA A N     1 
ATOM 3907 C CA    . ALA A 1 771 ? 132.452 120.977 94.022  1.00 69.34  ? 765 ALA A CA    1 
ATOM 3908 C C     . ALA A 1 771 ? 132.223 122.364 94.606  1.00 66.61  ? 765 ALA A C     1 
ATOM 3909 O O     . ALA A 1 771 ? 132.404 123.369 93.912  1.00 68.09  ? 765 ALA A O     1 
ATOM 3910 C CB    . ALA A 1 771 ? 133.868 120.836 93.465  1.00 67.76  ? 765 ALA A CB    1 
ATOM 3911 N N     . LYS A 1 772 ? 131.832 122.420 95.879  1.00 58.38  ? 766 LYS A N     1 
ATOM 3912 C CA    . LYS A 1 772 ? 131.439 123.683 96.488  1.00 56.10  ? 766 LYS A CA    1 
ATOM 3913 C C     . LYS A 1 772 ? 132.633 124.422 97.079  1.00 53.91  ? 766 LYS A C     1 
ATOM 3914 O O     . LYS A 1 772 ? 132.467 125.297 97.935  1.00 57.98  ? 766 LYS A O     1 
ATOM 3915 C CB    . LYS A 1 772 ? 130.375 123.446 97.563  1.00 62.30  ? 766 LYS A CB    1 
ATOM 3916 C CG    . LYS A 1 772 ? 130.853 122.624 98.747  1.00 61.68  ? 766 LYS A CG    1 
ATOM 3917 C CD    . LYS A 1 772 ? 129.926 122.786 99.943  1.00 57.85  ? 766 LYS A CD    1 
ATOM 3918 C CE    . LYS A 1 772 ? 130.628 122.419 101.239 1.00 58.84  ? 766 LYS A CE    1 
ATOM 3919 N NZ    . LYS A 1 772 ? 131.780 123.319 101.524 1.00 61.01  ? 766 LYS A NZ    1 
ATOM 3920 N N     . ASP A 1 773 ? 133.841 124.087 96.628  1.00 45.43  ? 767 ASP A N     1 
ATOM 3921 C CA    . ASP A 1 773 ? 135.037 124.780 97.073  1.00 49.89  ? 767 ASP A CA    1 
ATOM 3922 C C     . ASP A 1 773 ? 135.688 125.611 95.976  1.00 50.02  ? 767 ASP A C     1 
ATOM 3923 O O     . ASP A 1 773 ? 136.720 126.238 96.234  1.00 56.14  ? 767 ASP A O     1 
ATOM 3924 C CB    . ASP A 1 773 ? 136.064 123.784 97.631  1.00 56.80  ? 767 ASP A CB    1 
ATOM 3925 C CG    . ASP A 1 773 ? 136.607 122.846 96.571  1.00 55.65  ? 767 ASP A CG    1 
ATOM 3926 O OD1   . ASP A 1 773 ? 135.861 121.948 96.131  1.00 52.74  ? 767 ASP A OD1   1 
ATOM 3927 O OD2   . ASP A 1 773 ? 137.783 123.006 96.181  1.00 56.09  ? 767 ASP A OD2   1 
ATOM 3928 N N     . THR A 1 774 ? 135.123 125.635 94.772  1.00 43.76  ? 768 THR A N     1 
ATOM 3929 C CA    . THR A 1 774 ? 135.662 126.406 93.660  1.00 40.11  ? 768 THR A CA    1 
ATOM 3930 C C     . THR A 1 774 ? 134.622 127.423 93.217  1.00 41.66  ? 768 THR A C     1 
ATOM 3931 O O     . THR A 1 774 ? 133.472 127.063 92.945  1.00 45.67  ? 768 THR A O     1 
ATOM 3932 C CB    . THR A 1 774 ? 136.051 125.498 92.493  1.00 46.66  ? 768 THR A CB    1 
ATOM 3933 O OG1   . THR A 1 774 ? 134.973 124.603 92.202  1.00 56.43  ? 768 THR A OG1   1 
ATOM 3934 C CG2   . THR A 1 774 ? 137.292 124.694 92.836  1.00 47.29  ? 768 THR A CG2   1 
ATOM 3935 N N     . PHE A 1 775 ? 135.029 128.686 93.147  1.00 46.84  ? 769 PHE A N     1 
ATOM 3936 C CA    . PHE A 1 775 ? 134.185 129.784 92.700  1.00 50.41  ? 769 PHE A CA    1 
ATOM 3937 C C     . PHE A 1 775 ? 134.771 130.332 91.411  1.00 48.81  ? 769 PHE A C     1 
ATOM 3938 O O     . PHE A 1 775 ? 135.943 130.726 91.378  1.00 46.96  ? 769 PHE A O     1 
ATOM 3939 C CB    . PHE A 1 775 ? 134.102 130.873 93.770  1.00 48.24  ? 769 PHE A CB    1 
ATOM 3940 C CG    . PHE A 1 775 ? 133.292 132.064 93.362  1.00 42.06  ? 769 PHE A CG    1 
ATOM 3941 C CD1   . PHE A 1 775 ? 131.915 132.037 93.435  1.00 41.10  ? 769 PHE A CD1   1 
ATOM 3942 C CD2   . PHE A 1 775 ? 133.911 133.216 92.914  1.00 48.13  ? 769 PHE A CD2   1 
ATOM 3943 C CE1   . PHE A 1 775 ? 131.170 133.133 93.065  1.00 46.05  ? 769 PHE A CE1   1 
ATOM 3944 C CE2   . PHE A 1 775 ? 133.171 134.314 92.542  1.00 49.42  ? 769 PHE A CE2   1 
ATOM 3945 C CZ    . PHE A 1 775 ? 131.799 134.272 92.618  1.00 42.19  ? 769 PHE A CZ    1 
ATOM 3946 N N     . TYR A 1 776 ? 133.962 130.354 90.355  1.00 46.54  ? 770 TYR A N     1 
ATOM 3947 C CA    . TYR A 1 776 ? 134.409 130.740 89.024  1.00 45.37  ? 770 TYR A CA    1 
ATOM 3948 C C     . TYR A 1 776 ? 133.928 132.153 88.723  1.00 49.76  ? 770 TYR A C     1 
ATOM 3949 O O     . TYR A 1 776 ? 132.735 132.446 88.848  1.00 54.87  ? 770 TYR A O     1 
ATOM 3950 C CB    . TYR A 1 776 ? 133.879 129.771 87.969  1.00 49.63  ? 770 TYR A CB    1 
ATOM 3951 C CG    . TYR A 1 776 ? 134.382 128.352 88.099  1.00 47.46  ? 770 TYR A CG    1 
ATOM 3952 C CD1   . TYR A 1 776 ? 135.680 128.020 87.744  1.00 47.77  ? 770 TYR A CD1   1 
ATOM 3953 C CD2   . TYR A 1 776 ? 133.551 127.342 88.561  1.00 48.28  ? 770 TYR A CD2   1 
ATOM 3954 C CE1   . TYR A 1 776 ? 136.139 126.725 87.855  1.00 48.52  ? 770 TYR A CE1   1 
ATOM 3955 C CE2   . TYR A 1 776 ? 134.001 126.046 88.676  1.00 49.01  ? 770 TYR A CE2   1 
ATOM 3956 C CZ    . TYR A 1 776 ? 135.297 125.742 88.322  1.00 47.53  ? 770 TYR A CZ    1 
ATOM 3957 O OH    . TYR A 1 776 ? 135.750 124.449 88.434  1.00 51.96  ? 770 TYR A OH    1 
ATOM 3958 N N     . PHE A 1 777 ? 134.852 133.020 88.328  1.00 49.38  ? 771 PHE A N     1 
ATOM 3959 C CA    . PHE A 1 777 ? 134.520 134.361 87.871  1.00 46.32  ? 771 PHE A CA    1 
ATOM 3960 C C     . PHE A 1 777 ? 135.296 134.662 86.596  1.00 52.15  ? 771 PHE A C     1 
ATOM 3961 O O     . PHE A 1 777 ? 136.065 133.838 86.103  1.00 57.93  ? 771 PHE A O     1 
ATOM 3962 C CB    . PHE A 1 777 ? 134.798 135.403 88.961  1.00 51.50  ? 771 PHE A CB    1 
ATOM 3963 C CG    . PHE A 1 777 ? 136.253 135.562 89.303  1.00 48.53  ? 771 PHE A CG    1 
ATOM 3964 C CD1   . PHE A 1 777 ? 136.836 134.776 90.280  1.00 55.24  ? 771 PHE A CD1   1 
ATOM 3965 C CD2   . PHE A 1 777 ? 137.031 136.512 88.665  1.00 50.48  ? 771 PHE A CD2   1 
ATOM 3966 C CE1   . PHE A 1 777 ? 138.169 134.924 90.602  1.00 54.75  ? 771 PHE A CE1   1 
ATOM 3967 C CE2   . PHE A 1 777 ? 138.364 136.661 88.982  1.00 50.12  ? 771 PHE A CE2   1 
ATOM 3968 C CZ    . PHE A 1 777 ? 138.934 135.867 89.951  1.00 50.16  ? 771 PHE A CZ    1 
ATOM 3969 N N     . GLU A 1 778 ? 135.083 135.856 86.053  1.00 60.12  ? 772 GLU A N     1 
ATOM 3970 C CA    . GLU A 1 778 ? 135.759 136.290 84.841  1.00 59.99  ? 772 GLU A CA    1 
ATOM 3971 C C     . GLU A 1 778 ? 136.593 137.529 85.134  1.00 61.67  ? 772 GLU A C     1 
ATOM 3972 O O     . GLU A 1 778 ? 136.207 138.376 85.946  1.00 62.55  ? 772 GLU A O     1 
ATOM 3973 C CB    . GLU A 1 778 ? 134.753 136.565 83.708  1.00 57.85  ? 772 GLU A CB    1 
ATOM 3974 C CG    . GLU A 1 778 ? 134.222 137.986 83.642  1.00 66.80  ? 772 GLU A CG    1 
ATOM 3975 C CD    . GLU A 1 778 ? 133.243 138.301 84.757  1.00 72.05  ? 772 GLU A CD    1 
ATOM 3976 O OE1   . GLU A 1 778 ? 132.654 137.352 85.319  1.00 71.47  ? 772 GLU A OE1   1 
ATOM 3977 O OE2   . GLU A 1 778 ? 133.060 139.495 85.070  1.00 62.31  ? 772 GLU A OE2   1 
ATOM 3978 N N     . GLN A 1 779 ? 137.756 137.609 84.493  1.00 65.68  ? 773 GLN A N     1 
ATOM 3979 C CA    . GLN A 1 779 ? 138.661 138.740 84.660  1.00 61.85  ? 773 GLN A CA    1 
ATOM 3980 C C     . GLN A 1 779 ? 139.420 138.920 83.357  1.00 69.09  ? 773 GLN A C     1 
ATOM 3981 O O     . GLN A 1 779 ? 140.112 137.997 82.917  1.00 76.86  ? 773 GLN A O     1 
ATOM 3982 C CB    . GLN A 1 779 ? 139.625 138.510 85.823  1.00 57.94  ? 773 GLN A CB    1 
ATOM 3983 C CG    . GLN A 1 779 ? 140.190 139.782 86.426  1.00 62.75  ? 773 GLN A CG    1 
ATOM 3984 C CD    . GLN A 1 779 ? 141.111 139.507 87.595  1.00 66.38  ? 773 GLN A CD    1 
ATOM 3985 O OE1   . GLN A 1 779 ? 141.094 138.420 88.170  1.00 66.58  ? 773 GLN A OE1   1 
ATOM 3986 N NE2   . GLN A 1 779 ? 141.922 140.493 87.956  1.00 64.49  ? 773 GLN A NE2   1 
ATOM 3987 N N     . ASP A 1 780 ? 139.286 140.099 82.746  1.00 72.29  ? 774 ASP A N     1 
ATOM 3988 C CA    . ASP A 1 780 ? 139.844 140.367 81.419  1.00 72.43  ? 774 ASP A CA    1 
ATOM 3989 C C     . ASP A 1 780 ? 139.326 139.356 80.399  1.00 78.70  ? 774 ASP A C     1 
ATOM 3990 O O     . ASP A 1 780 ? 140.049 138.930 79.495  1.00 77.44  ? 774 ASP A O     1 
ATOM 3991 C CB    . ASP A 1 780 ? 141.373 140.382 81.446  1.00 71.96  ? 774 ASP A CB    1 
ATOM 3992 C CG    . ASP A 1 780 ? 141.926 141.311 82.507  1.00 76.66  ? 774 ASP A CG    1 
ATOM 3993 O OD1   . ASP A 1 780 ? 141.124 141.983 83.186  1.00 80.53  ? 774 ASP A OD1   1 
ATOM 3994 O OD2   . ASP A 1 780 ? 143.164 141.369 82.661  1.00 76.61  ? 774 ASP A OD2   1 
ATOM 3995 N N     . ARG A 1 781 ? 138.059 138.968 80.556  1.00 82.83  ? 775 ARG A N     1 
ATOM 3996 C CA    . ARG A 1 781 ? 137.393 137.999 79.685  1.00 80.80  ? 775 ARG A CA    1 
ATOM 3997 C C     . ARG A 1 781 ? 138.112 136.651 79.666  1.00 80.54  ? 775 ARG A C     1 
ATOM 3998 O O     . ARG A 1 781 ? 138.091 135.939 78.661  1.00 85.11  ? 775 ARG A O     1 
ATOM 3999 C CB    . ARG A 1 781 ? 137.232 138.543 78.261  1.00 83.27  ? 775 ARG A CB    1 
ATOM 4000 C CG    . ARG A 1 781 ? 136.528 139.894 78.177  1.00 81.39  ? 775 ARG A CG    1 
ATOM 4001 C CD    . ARG A 1 781 ? 135.086 139.854 78.690  1.00 83.22  ? 775 ARG A CD    1 
ATOM 4002 N NE    . ARG A 1 781 ? 134.490 138.524 78.632  1.00 86.67  ? 775 ARG A NE    1 
ATOM 4003 C CZ    . ARG A 1 781 ? 133.812 138.050 77.596  1.00 85.13  ? 775 ARG A CZ    1 
ATOM 4004 N NH1   . ARG A 1 781 ? 133.618 138.774 76.507  1.00 81.82  ? 775 ARG A NH1   1 
ATOM 4005 N NH2   . ARG A 1 781 ? 133.316 136.817 77.656  1.00 83.10  ? 775 ARG A NH2   1 
ATOM 4006 N N     . LYS A 1 782 ? 138.751 136.292 80.777  1.00 67.03  ? 776 LYS A N     1 
ATOM 4007 C CA    . LYS A 1 782 ? 139.349 134.977 80.953  1.00 69.38  ? 776 LYS A CA    1 
ATOM 4008 C C     . LYS A 1 782 ? 138.866 134.404 82.275  1.00 70.36  ? 776 LYS A C     1 
ATOM 4009 O O     . LYS A 1 782 ? 138.968 135.062 83.314  1.00 73.58  ? 776 LYS A O     1 
ATOM 4010 C CB    . LYS A 1 782 ? 140.878 135.042 80.920  1.00 70.23  ? 776 LYS A CB    1 
ATOM 4011 C CG    . LYS A 1 782 ? 141.537 133.726 80.546  1.00 74.36  ? 776 LYS A CG    1 
ATOM 4012 C CD    . LYS A 1 782 ? 143.028 133.890 80.303  1.00 74.10  ? 776 LYS A CD    1 
ATOM 4013 C CE    . LYS A 1 782 ? 143.703 134.615 81.455  1.00 70.43  ? 776 LYS A CE    1 
ATOM 4014 N NZ    . LYS A 1 782 ? 145.085 134.112 81.688  1.00 71.75  ? 776 LYS A NZ    1 
ATOM 4015 N N     . ILE A 1 783 ? 138.348 133.178 82.234  1.00 61.29  ? 777 ILE A N     1 
ATOM 4016 C CA    . ILE A 1 783 ? 137.698 132.596 83.402  1.00 58.94  ? 777 ILE A CA    1 
ATOM 4017 C C     . ILE A 1 783 ? 138.759 132.163 84.405  1.00 64.11  ? 777 ILE A C     1 
ATOM 4018 O O     . ILE A 1 783 ? 139.655 131.374 84.083  1.00 68.58  ? 777 ILE A O     1 
ATOM 4019 C CB    . ILE A 1 783 ? 136.806 131.417 82.997  1.00 63.29  ? 777 ILE A CB    1 
ATOM 4020 C CG1   . ILE A 1 783 ? 135.688 131.894 82.068  1.00 63.50  ? 777 ILE A CG1   1 
ATOM 4021 C CG2   . ILE A 1 783 ? 136.244 130.730 84.232  1.00 61.84  ? 777 ILE A CG2   1 
ATOM 4022 C CD1   . ILE A 1 783 ? 134.415 132.274 82.779  1.00 63.19  ? 777 ILE A CD1   1 
ATOM 4023 N N     . HIS A 1 784 ? 138.662 132.680 85.625  1.00 59.45  ? 778 HIS A N     1 
ATOM 4024 C CA    . HIS A 1 784 ? 139.513 132.280 86.735  1.00 56.13  ? 778 HIS A CA    1 
ATOM 4025 C C     . HIS A 1 784 ? 138.670 131.611 87.812  1.00 58.85  ? 778 HIS A C     1 
ATOM 4026 O O     . HIS A 1 784 ? 137.442 131.745 87.848  1.00 63.37  ? 778 HIS A O     1 
ATOM 4027 C CB    . HIS A 1 784 ? 140.259 133.476 87.339  1.00 55.61  ? 778 HIS A CB    1 
ATOM 4028 C CG    . HIS A 1 784 ? 141.152 134.197 86.376  1.00 63.35  ? 778 HIS A CG    1 
ATOM 4029 N ND1   . HIS A 1 784 ? 141.149 133.951 85.020  1.00 66.24  ? 778 HIS A ND1   1 
ATOM 4030 C CD2   . HIS A 1 784 ? 142.085 135.156 86.581  1.00 63.32  ? 778 HIS A CD2   1 
ATOM 4031 C CE1   . HIS A 1 784 ? 142.036 134.731 84.430  1.00 67.22  ? 778 HIS A CE1   1 
ATOM 4032 N NE2   . HIS A 1 784 ? 142.619 135.471 85.355  1.00 65.01  ? 778 HIS A NE2   1 
ATOM 4033 N N     . ARG A 1 785 ? 139.347 130.888 88.700  1.00 52.45  ? 779 ARG A N     1 
ATOM 4034 C CA    . ARG A 1 785 ? 138.694 130.242 89.826  1.00 47.65  ? 779 ARG A CA    1 
ATOM 4035 C C     . ARG A 1 785 ? 139.458 130.557 91.105  1.00 55.38  ? 779 ARG A C     1 
ATOM 4036 O O     . ARG A 1 785 ? 140.658 130.837 91.087  1.00 59.40  ? 779 ARG A O     1 
ATOM 4037 C CB    . ARG A 1 785 ? 138.590 128.721 89.635  1.00 49.43  ? 779 ARG A CB    1 
ATOM 4038 C CG    . ARG A 1 785 ? 139.897 127.976 89.814  1.00 57.62  ? 779 ARG A CG    1 
ATOM 4039 C CD    . ARG A 1 785 ? 139.791 126.548 89.311  1.00 54.99  ? 779 ARG A CD    1 
ATOM 4040 N NE    . ARG A 1 785 ? 141.038 126.090 88.708  1.00 59.00  ? 779 ARG A NE    1 
ATOM 4041 C CZ    . ARG A 1 785 ? 141.708 125.019 89.103  1.00 58.39  ? 779 ARG A CZ    1 
ATOM 4042 N NH1   . ARG A 1 785 ? 141.277 124.261 90.097  1.00 60.17  ? 779 ARG A NH1   1 
ATOM 4043 N NH2   . ARG A 1 785 ? 142.841 124.697 88.485  1.00 59.57  ? 779 ARG A NH2   1 
ATOM 4044 N N     . ILE A 1 786 ? 138.731 130.515 92.220  1.00 53.04  ? 780 ILE A N     1 
ATOM 4045 C CA    . ILE A 1 786 ? 139.305 130.798 93.531  1.00 49.61  ? 780 ILE A CA    1 
ATOM 4046 C C     . ILE A 1 786 ? 138.640 129.867 94.531  1.00 51.58  ? 780 ILE A C     1 
ATOM 4047 O O     . ILE A 1 786 ? 137.629 129.230 94.226  1.00 54.23  ? 780 ILE A O     1 
ATOM 4048 C CB    . ILE A 1 786 ? 139.116 132.288 93.911  1.00 48.65  ? 780 ILE A CB    1 
ATOM 4049 C CG1   . ILE A 1 786 ? 139.976 132.668 95.120  1.00 48.48  ? 780 ILE A CG1   1 
ATOM 4050 C CG2   . ILE A 1 786 ? 137.650 132.584 94.178  1.00 43.80  ? 780 ILE A CG2   1 
ATOM 4051 C CD1   . ILE A 1 786 ? 139.660 134.027 95.699  1.00 51.50  ? 780 ILE A CD1   1 
ATOM 4052 N N     . ASP A 1 787 ? 139.229 129.755 95.720  1.00 55.26  ? 781 ASP A N     1 
ATOM 4053 C CA    . ASP A 1 787 ? 138.557 129.076 96.818  1.00 49.38  ? 781 ASP A CA    1 
ATOM 4054 C C     . ASP A 1 787 ? 137.272 129.813 97.169  1.00 45.13  ? 781 ASP A C     1 
ATOM 4055 O O     . ASP A 1 787 ? 137.263 131.039 97.294  1.00 53.89  ? 781 ASP A O     1 
ATOM 4056 C CB    . ASP A 1 787 ? 139.481 129.003 98.033  1.00 49.08  ? 781 ASP A CB    1 
ATOM 4057 C CG    . ASP A 1 787 ? 139.336 127.707 98.799  1.00 54.50  ? 781 ASP A CG    1 
ATOM 4058 O OD1   . ASP A 1 787 ? 138.228 127.435 99.309  1.00 56.85  ? 781 ASP A OD1   1 
ATOM 4059 O OD2   . ASP A 1 787 ? 140.330 126.959 98.895  1.00 58.67  ? 781 ASP A OD2   1 
ATOM 4060 N N     . ALA A 1 788 ? 136.185 129.064 97.327  1.00 34.87  ? 782 ALA A N     1 
ATOM 4061 C CA    . ALA A 1 788 ? 134.871 129.664 97.516  1.00 41.55  ? 782 ALA A CA    1 
ATOM 4062 C C     . ALA A 1 788 ? 134.614 130.110 98.948  1.00 45.50  ? 782 ALA A C     1 
ATOM 4063 O O     . ALA A 1 788 ? 133.581 130.735 99.204  1.00 51.14  ? 782 ALA A O     1 
ATOM 4064 C CB    . ALA A 1 788 ? 133.778 128.688 97.079  1.00 51.31  ? 782 ALA A CB    1 
ATOM 4065 N N     . ASP A 1 789 ? 135.516 129.807 99.876  1.00 39.62  ? 783 ASP A N     1 
ATOM 4066 C CA    . ASP A 1 789 ? 135.383 130.221 101.267 1.00 38.21  ? 783 ASP A CA    1 
ATOM 4067 C C     . ASP A 1 789 ? 136.288 131.385 101.631 1.00 46.35  ? 783 ASP A C     1 
ATOM 4068 O O     . ASP A 1 789 ? 135.852 132.308 102.324 1.00 55.60  ? 783 ASP A O     1 
ATOM 4069 C CB    . ASP A 1 789 ? 135.672 129.040 102.197 1.00 39.96  ? 783 ASP A CB    1 
ATOM 4070 C CG    . ASP A 1 789 ? 134.865 127.812 101.837 1.00 52.94  ? 783 ASP A CG    1 
ATOM 4071 O OD1   . ASP A 1 789 ? 133.638 127.820 102.069 1.00 51.53  ? 783 ASP A OD1   1 
ATOM 4072 O OD2   . ASP A 1 789 ? 135.453 126.843 101.317 1.00 59.70  ? 783 ASP A OD2   1 
ATOM 4073 N N     . VAL A 1 790 ? 137.540 131.377 101.167 1.00 38.03  ? 784 VAL A N     1 
ATOM 4074 C CA    . VAL A 1 790 ? 138.353 132.579 101.304 1.00 25.69  ? 784 VAL A CA    1 
ATOM 4075 C C     . VAL A 1 790 ? 137.748 133.707 100.483 1.00 40.64  ? 784 VAL A C     1 
ATOM 4076 O O     . VAL A 1 790 ? 137.893 134.882 100.835 1.00 49.68  ? 784 VAL A O     1 
ATOM 4077 C CB    . VAL A 1 790 ? 139.815 132.305 100.906 1.00 30.98  ? 784 VAL A CB    1 
ATOM 4078 C CG1   . VAL A 1 790 ? 140.309 131.024 101.549 1.00 42.83  ? 784 VAL A CG1   1 
ATOM 4079 C CG2   . VAL A 1 790 ? 139.982 132.264 99.396  1.00 38.76  ? 784 VAL A CG2   1 
ATOM 4080 N N     . ASN A 1 791 ? 137.048 133.375 99.397  1.00 43.26  ? 785 ASN A N     1 
ATOM 4081 C CA    . ASN A 1 791 ? 136.343 134.392 98.624  1.00 29.63  ? 785 ASN A CA    1 
ATOM 4082 C C     . ASN A 1 791 ? 135.289 135.085 99.476  1.00 29.64  ? 785 ASN A C     1 
ATOM 4083 O O     . ASN A 1 791 ? 135.206 136.318 99.501  1.00 44.11  ? 785 ASN A O     1 
ATOM 4084 C CB    . ASN A 1 791 ? 135.705 133.753 97.390  1.00 36.03  ? 785 ASN A CB    1 
ATOM 4085 C CG    . ASN A 1 791 ? 135.201 134.773 96.402  1.00 36.30  ? 785 ASN A CG    1 
ATOM 4086 O OD1   . ASN A 1 791 ? 135.942 135.231 95.535  1.00 41.60  ? 785 ASN A OD1   1 
ATOM 4087 N ND2   . ASN A 1 791 ? 133.926 135.123 96.513  1.00 38.95  ? 785 ASN A ND2   1 
ATOM 4088 N N     . ALA A 1 792 ? 134.492 134.306 100.208 1.00 24.28  ? 786 ALA A N     1 
ATOM 4089 C CA    . ALA A 1 792 ? 133.473 134.901 101.065 1.00 26.61  ? 786 ALA A CA    1 
ATOM 4090 C C     . ALA A 1 792 ? 134.087 135.624 102.256 1.00 37.74  ? 786 ALA A C     1 
ATOM 4091 O O     . ALA A 1 792 ? 133.541 136.635 102.708 1.00 49.82  ? 786 ALA A O     1 
ATOM 4092 C CB    . ALA A 1 792 ? 132.493 133.833 101.538 1.00 31.55  ? 786 ALA A CB    1 
ATOM 4093 N N     . ALA A 1 793 ? 135.209 135.125 102.781 1.00 23.02  ? 787 ALA A N     1 
ATOM 4094 C CA    . ALA A 1 793 ? 135.894 135.833 103.860 1.00 10.05  ? 787 ALA A CA    1 
ATOM 4095 C C     . ALA A 1 793 ? 136.383 137.201 103.396 1.00 24.67  ? 787 ALA A C     1 
ATOM 4096 O O     . ALA A 1 793 ? 136.192 138.213 104.085 1.00 41.23  ? 787 ALA A O     1 
ATOM 4097 C CB    . ALA A 1 793 ? 137.060 134.991 104.375 1.00 27.13  ? 787 ALA A CB    1 
ATOM 4098 N N     . ILE A 1 794 ? 137.004 137.252 102.217 1.00 17.76  ? 788 ILE A N     1 
ATOM 4099 C CA    . ILE A 1 794 ? 137.465 138.522 101.673 1.00 3.97   ? 788 ILE A CA    1 
ATOM 4100 C C     . ILE A 1 794 ? 136.285 139.426 101.353 1.00 19.61  ? 788 ILE A C     1 
ATOM 4101 O O     . ILE A 1 794 ? 136.375 140.644 101.511 1.00 39.21  ? 788 ILE A O     1 
ATOM 4102 C CB    . ILE A 1 794 ? 138.356 138.289 100.441 1.00 14.07  ? 788 ILE A CB    1 
ATOM 4103 C CG1   . ILE A 1 794 ? 139.645 137.580 100.847 1.00 23.93  ? 788 ILE A CG1   1 
ATOM 4104 C CG2   . ILE A 1 794 ? 138.698 139.604 99.772  1.00 31.34  ? 788 ILE A CG2   1 
ATOM 4105 C CD1   . ILE A 1 794 ? 140.444 137.059 99.680  1.00 27.69  ? 788 ILE A CD1   1 
ATOM 4106 N N     . ASN A 1 795 ? 135.165 138.859 100.903 1.00 20.37  ? 789 ASN A N     1 
ATOM 4107 C CA    . ASN A 1 795 ? 133.985 139.681 100.650 1.00 24.06  ? 789 ASN A CA    1 
ATOM 4108 C C     . ASN A 1 795 ? 133.431 140.275 101.940 1.00 23.43  ? 789 ASN A C     1 
ATOM 4109 O O     . ASN A 1 795 ? 132.999 141.430 101.959 1.00 32.19  ? 789 ASN A O     1 
ATOM 4110 C CB    . ASN A 1 795 ? 132.915 138.862 99.934  1.00 31.14  ? 789 ASN A CB    1 
ATOM 4111 C CG    . ASN A 1 795 ? 133.138 138.801 98.440  1.00 35.96  ? 789 ASN A CG    1 
ATOM 4112 O OD1   . ASN A 1 795 ? 133.562 139.778 97.825  1.00 30.73  ? 789 ASN A OD1   1 
ATOM 4113 N ND2   . ASN A 1 795 ? 132.853 137.651 97.847  1.00 39.79  ? 789 ASN A ND2   1 
ATOM 4114 N N     . ILE A 1 796 ? 133.434 139.500 103.026 1.00 16.19  ? 790 ILE A N     1 
ATOM 4115 C CA    . ILE A 1 796 ? 132.991 140.019 104.318 1.00 20.80  ? 790 ILE A CA    1 
ATOM 4116 C C     . ILE A 1 796 ? 133.893 141.165 104.762 1.00 31.04  ? 790 ILE A C     1 
ATOM 4117 O O     . ILE A 1 796 ? 133.421 142.232 105.178 1.00 42.00  ? 790 ILE A O     1 
ATOM 4118 C CB    . ILE A 1 796 ? 132.958 138.891 105.365 1.00 10.40  ? 790 ILE A CB    1 
ATOM 4119 C CG1   . ILE A 1 796 ? 131.778 137.955 105.111 1.00 19.20  ? 790 ILE A CG1   1 
ATOM 4120 C CG2   . ILE A 1 796 ? 132.878 139.467 106.761 1.00 17.25  ? 790 ILE A CG2   1 
ATOM 4121 C CD1   . ILE A 1 796 ? 130.435 138.608 105.306 1.00 24.45  ? 790 ILE A CD1   1 
ATOM 4122 N N     . ALA A 1 797 ? 135.209 140.962 104.664 1.00 24.47  ? 791 ALA A N     1 
ATOM 4123 C CA    . ALA A 1 797 ? 136.143 142.013 105.054 1.00 10.45  ? 791 ALA A CA    1 
ATOM 4124 C C     . ALA A 1 797 ? 135.990 143.247 104.173 1.00 17.62  ? 791 ALA A C     1 
ATOM 4125 O O     . ALA A 1 797 ? 136.064 144.380 104.662 1.00 42.31  ? 791 ALA A O     1 
ATOM 4126 C CB    . ALA A 1 797 ? 137.575 141.486 105.004 1.00 26.21  ? 791 ALA A CB    1 
ATOM 4127 N N     . ARG A 1 798 ? 135.780 143.049 102.870 1.00 17.77  ? 792 ARG A N     1 
ATOM 4128 C CA    . ARG A 1 798 ? 135.598 144.163 101.945 1.00 17.33  ? 792 ARG A CA    1 
ATOM 4129 C C     . ARG A 1 798 ? 134.329 144.942 102.255 1.00 27.34  ? 792 ARG A C     1 
ATOM 4130 O O     . ARG A 1 798 ? 134.320 146.175 102.194 1.00 43.17  ? 792 ARG A O     1 
ATOM 4131 C CB    . ARG A 1 798 ? 135.561 143.633 100.513 1.00 27.64  ? 792 ARG A CB    1 
ATOM 4132 C CG    . ARG A 1 798 ? 136.387 144.413 99.514  1.00 34.42  ? 792 ARG A CG    1 
ATOM 4133 C CD    . ARG A 1 798 ? 136.498 143.646 98.206  1.00 28.84  ? 792 ARG A CD    1 
ATOM 4134 N NE    . ARG A 1 798 ? 136.643 144.528 97.054  1.00 31.64  ? 792 ARG A NE    1 
ATOM 4135 C CZ    . ARG A 1 798 ? 135.639 145.157 96.459  1.00 34.89  ? 792 ARG A CZ    1 
ATOM 4136 N NH1   . ARG A 1 798 ? 134.393 145.027 96.884  1.00 37.22  ? 792 ARG A NH1   1 
ATOM 4137 N NH2   . ARG A 1 798 ? 135.892 145.933 95.410  1.00 32.76  ? 792 ARG A NH2   1 
ATOM 4138 N N     . ARG A 1 799 ? 133.243 144.237 102.574 1.00 23.75  ? 793 ARG A N     1 
ATOM 4139 C CA    . ARG A 1 799 ? 132.005 144.909 102.947 1.00 23.88  ? 793 ARG A CA    1 
ATOM 4140 C C     . ARG A 1 799 ? 132.185 145.702 104.232 1.00 27.92  ? 793 ARG A C     1 
ATOM 4141 O O     . ARG A 1 799 ? 131.625 146.792 104.382 1.00 38.31  ? 793 ARG A O     1 
ATOM 4142 C CB    . ARG A 1 799 ? 130.886 143.884 103.101 1.00 24.38  ? 793 ARG A CB    1 
ATOM 4143 C CG    . ARG A 1 799 ? 129.494 144.472 103.163 1.00 29.12  ? 793 ARG A CG    1 
ATOM 4144 C CD    . ARG A 1 799 ? 128.461 143.400 102.881 1.00 30.12  ? 793 ARG A CD    1 
ATOM 4145 N NE    . ARG A 1 799 ? 128.496 142.972 101.488 1.00 27.09  ? 793 ARG A NE    1 
ATOM 4146 C CZ    . ARG A 1 799 ? 127.582 142.199 100.920 1.00 28.90  ? 793 ARG A CZ    1 
ATOM 4147 N NH1   . ARG A 1 799 ? 126.546 141.741 101.600 1.00 34.06  ? 793 ARG A NH1   1 
ATOM 4148 N NH2   . ARG A 1 799 ? 127.714 141.875 99.638  1.00 39.92  ? 793 ARG A NH2   1 
ATOM 4149 N N     . PHE A 1 800 ? 132.955 145.160 105.178 1.00 25.51  ? 794 PHE A N     1 
ATOM 4150 C CA    . PHE A 1 800 ? 133.205 145.881 106.422 1.00 18.99  ? 794 PHE A CA    1 
ATOM 4151 C C     . PHE A 1 800 ? 134.038 147.135 106.182 1.00 19.59  ? 794 PHE A C     1 
ATOM 4152 O O     . PHE A 1 800 ? 133.705 148.217 106.677 1.00 38.15  ? 794 PHE A O     1 
ATOM 4153 C CB    . PHE A 1 800 ? 133.895 144.960 107.428 1.00 26.11  ? 794 PHE A CB    1 
ATOM 4154 C CG    . PHE A 1 800 ? 134.043 145.559 108.796 1.00 23.57  ? 794 PHE A CG    1 
ATOM 4155 C CD1   . PHE A 1 800 ? 132.931 145.819 109.576 1.00 28.64  ? 794 PHE A CD1   1 
ATOM 4156 C CD2   . PHE A 1 800 ? 135.293 145.850 109.305 1.00 20.50  ? 794 PHE A CD2   1 
ATOM 4157 C CE1   . PHE A 1 800 ? 133.066 146.364 110.837 1.00 26.44  ? 794 PHE A CE1   1 
ATOM 4158 C CE2   . PHE A 1 800 ? 135.433 146.395 110.563 1.00 21.24  ? 794 PHE A CE2   1 
ATOM 4159 C CZ    . PHE A 1 800 ? 134.318 146.652 111.330 1.00 22.79  ? 794 PHE A CZ    1 
ATOM 4160 N N     . LEU A 1 801 ? 135.124 147.012 105.416 1.00 20.78  ? 795 LEU A N     1 
ATOM 4161 C CA    . LEU A 1 801 ? 136.056 148.123 105.259 1.00 19.67  ? 795 LEU A CA    1 
ATOM 4162 C C     . LEU A 1 801 ? 135.538 149.199 104.314 1.00 27.09  ? 795 LEU A C     1 
ATOM 4163 O O     . LEU A 1 801 ? 135.839 150.380 104.512 1.00 41.04  ? 795 LEU A O     1 
ATOM 4164 C CB    . LEU A 1 801 ? 137.407 147.610 104.768 1.00 25.46  ? 795 LEU A CB    1 
ATOM 4165 C CG    . LEU A 1 801 ? 138.121 146.637 105.701 1.00 28.65  ? 795 LEU A CG    1 
ATOM 4166 C CD1   . LEU A 1 801 ? 139.036 145.732 104.902 1.00 29.92  ? 795 LEU A CD1   1 
ATOM 4167 C CD2   . LEU A 1 801 ? 138.899 147.388 106.765 1.00 30.15  ? 795 LEU A CD2   1 
ATOM 4168 N N     . THR A 1 802 ? 134.780 148.826 103.289 1.00 25.28  ? 796 THR A N     1 
ATOM 4169 C CA    . THR A 1 802 ? 134.205 149.801 102.374 1.00 30.17  ? 796 THR A CA    1 
ATOM 4170 C C     . THR A 1 802 ? 132.893 150.379 102.883 1.00 35.56  ? 796 THR A C     1 
ATOM 4171 O O     . THR A 1 802 ? 132.277 151.190 102.183 1.00 42.41  ? 796 THR A O     1 
ATOM 4172 C CB    . THR A 1 802 ? 133.986 149.180 100.990 1.00 31.27  ? 796 THR A CB    1 
ATOM 4173 O OG1   . THR A 1 802 ? 133.126 148.042 101.103 1.00 34.62  ? 796 THR A OG1   1 
ATOM 4174 C CG2   . THR A 1 802 ? 135.305 148.749 100.389 1.00 35.74  ? 796 THR A CG2   1 
ATOM 4175 N N     . ARG A 1 803 ? 132.457 149.980 104.079 1.00 30.01  ? 797 ARG A N     1 
ATOM 4176 C CA    . ARG A 1 803 ? 131.218 150.467 104.681 1.00 27.44  ? 797 ARG A CA    1 
ATOM 4177 C C     . ARG A 1 803 ? 130.025 150.232 103.758 1.00 34.02  ? 797 ARG A C     1 
ATOM 4178 O O     . ARG A 1 803 ? 129.135 151.075 103.639 1.00 43.65  ? 797 ARG A O     1 
ATOM 4179 C CB    . ARG A 1 803 ? 131.332 151.943 105.066 1.00 34.25  ? 797 ARG A CB    1 
ATOM 4180 C CG    . ARG A 1 803 ? 132.373 152.220 106.138 1.00 27.99  ? 797 ARG A CG    1 
ATOM 4181 C CD    . ARG A 1 803 ? 132.610 153.711 106.317 1.00 34.30  ? 797 ARG A CD    1 
ATOM 4182 N NE    . ARG A 1 803 ? 131.590 154.328 107.157 1.00 43.32  ? 797 ARG A NE    1 
ATOM 4183 C CZ    . ARG A 1 803 ? 131.474 155.633 107.358 1.00 38.23  ? 797 ARG A CZ    1 
ATOM 4184 N NH1   . ARG A 1 803 ? 132.301 156.495 106.793 1.00 38.32  ? 797 ARG A NH1   1 
ATOM 4185 N NH2   . ARG A 1 803 ? 130.501 156.083 108.145 1.00 35.20  ? 797 ARG A NH2   1 
ATOM 4186 N N     . TYR A 1 804 ? 130.012 149.069 103.102 1.00 35.69  ? 798 TYR A N     1 
ATOM 4187 C CA    . TYR A 1 804 ? 128.940 148.680 102.185 1.00 32.24  ? 798 TYR A CA    1 
ATOM 4188 C C     . TYR A 1 804 ? 128.790 149.700 101.059 1.00 38.68  ? 798 TYR A C     1 
ATOM 4189 O O     . TYR A 1 804 ? 127.700 150.205 100.785 1.00 45.63  ? 798 TYR A O     1 
ATOM 4190 C CB    . TYR A 1 804 ? 127.622 148.481 102.933 1.00 35.85  ? 798 TYR A CB    1 
ATOM 4191 C CG    . TYR A 1 804 ? 126.804 147.317 102.432 1.00 32.32  ? 798 TYR A CG    1 
ATOM 4192 C CD1   . TYR A 1 804 ? 126.905 146.885 101.119 1.00 37.18  ? 798 TYR A CD1   1 
ATOM 4193 C CD2   . TYR A 1 804 ? 125.928 146.649 103.274 1.00 33.25  ? 798 TYR A CD2   1 
ATOM 4194 C CE1   . TYR A 1 804 ? 126.157 145.823 100.657 1.00 41.64  ? 798 TYR A CE1   1 
ATOM 4195 C CE2   . TYR A 1 804 ? 125.177 145.585 102.823 1.00 36.33  ? 798 TYR A CE2   1 
ATOM 4196 C CZ    . TYR A 1 804 ? 125.295 145.177 101.514 1.00 41.00  ? 798 TYR A CZ    1 
ATOM 4197 O OH    . TYR A 1 804 ? 124.549 144.117 101.058 1.00 41.58  ? 798 TYR A OH    1 
ATOM 4198 N N     . ARG A 1 805 ? 129.913 150.009 100.408 1.00 41.89  ? 799 ARG A N     1 
ATOM 4199 C CA    . ARG A 1 805 ? 129.905 150.994 99.333  1.00 41.76  ? 799 ARG A CA    1 
ATOM 4200 C C     . ARG A 1 805 ? 129.046 150.533 98.163  1.00 45.63  ? 799 ARG A C     1 
ATOM 4201 O O     . ARG A 1 805 ? 128.277 151.322 97.602  1.00 53.82  ? 799 ARG A O     1 
ATOM 4202 C CB    . ARG A 1 805 ? 131.336 151.274 98.877  1.00 44.02  ? 799 ARG A CB    1 
ATOM 4203 C CG    . ARG A 1 805 ? 131.453 151.877 97.491  1.00 45.80  ? 799 ARG A CG    1 
ATOM 4204 C CD    . ARG A 1 805 ? 131.119 153.354 97.497  1.00 45.23  ? 799 ARG A CD    1 
ATOM 4205 N NE    . ARG A 1 805 ? 131.017 153.885 96.143  1.00 50.91  ? 799 ARG A NE    1 
ATOM 4206 C CZ    . ARG A 1 805 ? 129.874 154.072 95.496  1.00 51.78  ? 799 ARG A CZ    1 
ATOM 4207 N NH1   . ARG A 1 805 ? 128.710 153.789 96.055  1.00 55.81  ? 799 ARG A NH1   1 
ATOM 4208 N NH2   . ARG A 1 805 ? 129.902 154.555 94.257  1.00 49.12  ? 799 ARG A NH2   1 
ATOM 4209 N N     . SER A 1 806 ? 129.152 149.263 97.787  1.00 45.29  ? 800 SER A N     1 
ATOM 4210 C CA    . SER A 1 806 ? 128.439 148.720 96.640  1.00 50.87  ? 800 SER A CA    1 
ATOM 4211 C C     . SER A 1 806 ? 127.433 147.669 97.088  1.00 51.69  ? 800 SER A C     1 
ATOM 4212 O O     . SER A 1 806 ? 127.748 146.806 97.911  1.00 54.00  ? 800 SER A O     1 
ATOM 4213 C CB    . SER A 1 806 ? 129.412 148.107 95.633  1.00 51.27  ? 800 SER A CB    1 
ATOM 4214 O OG    . SER A 1 806 ? 129.876 146.846 96.080  1.00 51.72  ? 800 SER A OG    1 
ATOM 4215 N N     . LEU A 1 807 ? 126.225 147.748 96.540  1.00 44.67  ? 801 LEU A N     1 
ATOM 4216 C CA    . LEU A 1 807 ? 125.182 146.759 96.770  1.00 47.05  ? 801 LEU A CA    1 
ATOM 4217 C C     . LEU A 1 807 ? 124.961 145.946 95.504  1.00 50.24  ? 801 LEU A C     1 
ATOM 4218 O O     . LEU A 1 807 ? 124.886 146.506 94.406  1.00 53.35  ? 801 LEU A O     1 
ATOM 4219 C CB    . LEU A 1 807 ? 123.873 147.420 97.208  1.00 46.52  ? 801 LEU A CB    1 
ATOM 4220 C CG    . LEU A 1 807 ? 123.779 147.818 98.680  1.00 48.90  ? 801 LEU A CG    1 
ATOM 4221 C CD1   . LEU A 1 807 ? 124.440 149.153 98.934  1.00 53.75  ? 801 LEU A CD1   1 
ATOM 4222 C CD2   . LEU A 1 807 ? 122.326 147.847 99.116  1.00 51.36  ? 801 LEU A CD2   1 
ATOM 4223 N N     . THR A 1 808 ? 124.861 144.630 95.664  1.00 48.37  ? 802 THR A N     1 
ATOM 4224 C CA    . THR A 1 808 ? 124.667 143.716 94.547  1.00 51.71  ? 802 THR A CA    1 
ATOM 4225 C C     . THR A 1 808 ? 123.201 143.412 94.267  1.00 49.28  ? 802 THR A C     1 
ATOM 4226 O O     . THR A 1 808 ? 122.908 142.705 93.299  1.00 53.32  ? 802 THR A O     1 
ATOM 4227 C CB    . THR A 1 808 ? 125.418 142.406 94.804  1.00 49.29  ? 802 THR A CB    1 
ATOM 4228 O OG1   . THR A 1 808 ? 125.197 141.985 96.155  1.00 49.67  ? 802 THR A OG1   1 
ATOM 4229 C CG2   . THR A 1 808 ? 126.905 142.592 94.581  1.00 46.76  ? 802 THR A CG2   1 
ATOM 4230 N N     . GLN A 1 809 ? 122.276 143.920 95.078  1.00 44.80  ? 803 GLN A N     1 
ATOM 4231 C CA    . GLN A 1 809 ? 120.862 143.642 94.878  1.00 46.23  ? 803 GLN A CA    1 
ATOM 4232 C C     . GLN A 1 809 ? 120.033 144.812 95.385  1.00 54.14  ? 803 GLN A C     1 
ATOM 4233 O O     . GLN A 1 809 ? 120.335 145.387 96.434  1.00 60.28  ? 803 GLN A O     1 
ATOM 4234 C CB    . GLN A 1 809 ? 120.441 142.354 95.587  1.00 49.78  ? 803 GLN A CB    1 
ATOM 4235 C CG    . GLN A 1 809 ? 119.117 141.789 95.104  1.00 51.90  ? 803 GLN A CG    1 
ATOM 4236 C CD    . GLN A 1 809 ? 118.541 140.758 96.051  1.00 53.30  ? 803 GLN A CD    1 
ATOM 4237 O OE1   . GLN A 1 809 ? 118.949 139.597 96.044  1.00 52.01  ? 803 GLN A OE1   1 
ATOM 4238 N NE2   . GLN A 1 809 ? 117.589 141.178 96.875  1.00 54.62  ? 803 GLN A NE2   1 
ATOM 4239 N N     . LEU A 1 810 ? 118.986 145.150 94.636  1.00 61.20  ? 804 LEU A N     1 
ATOM 4240 C CA    . LEU A 1 810 ? 118.075 146.235 94.984  1.00 53.92  ? 804 LEU A CA    1 
ATOM 4241 C C     . LEU A 1 810 ? 116.647 145.727 94.877  1.00 53.77  ? 804 LEU A C     1 
ATOM 4242 O O     . LEU A 1 810 ? 116.278 145.114 93.871  1.00 57.62  ? 804 LEU A O     1 
ATOM 4243 C CB    . LEU A 1 810 ? 118.283 147.445 94.070  1.00 47.35  ? 804 LEU A CB    1 
ATOM 4244 C CG    . LEU A 1 810 ? 119.084 148.617 94.635  1.00 51.54  ? 804 LEU A CG    1 
ATOM 4245 C CD1   . LEU A 1 810 ? 119.141 149.750 93.629  1.00 55.35  ? 804 LEU A CD1   1 
ATOM 4246 C CD2   . LEU A 1 810 ? 118.485 149.096 95.945  1.00 55.44  ? 804 LEU A CD2   1 
ATOM 4247 N N     . TRP A 1 811 ? 115.847 145.981 95.909  1.00 61.72  ? 805 TRP A N     1 
ATOM 4248 C CA    . TRP A 1 811 ? 114.437 145.614 95.907  1.00 67.00  ? 805 TRP A CA    1 
ATOM 4249 C C     . TRP A 1 811 ? 113.612 146.761 95.338  1.00 69.60  ? 805 TRP A C     1 
ATOM 4250 O O     . TRP A 1 811 ? 113.695 147.893 95.823  1.00 73.93  ? 805 TRP A O     1 
ATOM 4251 C CB    . TRP A 1 811 ? 113.968 145.270 97.322  1.00 68.82  ? 805 TRP A CB    1 
ATOM 4252 C CG    . TRP A 1 811 ? 114.042 143.811 97.643  1.00 67.47  ? 805 TRP A CG    1 
ATOM 4253 C CD1   . TRP A 1 811 ? 114.564 142.825 96.858  1.00 66.35  ? 805 TRP A CD1   1 
ATOM 4254 C CD2   . TRP A 1 811 ? 113.585 143.171 98.839  1.00 69.98  ? 805 TRP A CD2   1 
ATOM 4255 N NE1   . TRP A 1 811 ? 114.456 141.611 97.490  1.00 69.99  ? 805 TRP A NE1   1 
ATOM 4256 C CE2   . TRP A 1 811 ? 113.857 141.796 98.708  1.00 73.23  ? 805 TRP A CE2   1 
ATOM 4257 C CE3   . TRP A 1 811 ? 112.966 143.628 100.008 1.00 69.61  ? 805 TRP A CE3   1 
ATOM 4258 C CZ2   . TRP A 1 811 ? 113.537 140.873 99.701  1.00 73.26  ? 805 TRP A CZ2   1 
ATOM 4259 C CZ3   . TRP A 1 811 ? 112.649 142.709 100.992 1.00 68.02  ? 805 TRP A CZ3   1 
ATOM 4260 C CH2   . TRP A 1 811 ? 112.934 141.349 100.832 1.00 69.00  ? 805 TRP A CH2   1 
ATOM 4261 N N     . ALA A 1 812 ? 112.816 146.465 94.313  1.00 65.02  ? 806 ALA A N     1 
ATOM 4262 C CA    . ALA A 1 812 ? 112.055 147.488 93.612  1.00 63.89  ? 806 ALA A CA    1 
ATOM 4263 C C     . ALA A 1 812 ? 110.695 146.932 93.214  1.00 69.21  ? 806 ALA A C     1 
ATOM 4264 O O     . ALA A 1 812 ? 110.476 145.717 93.187  1.00 69.79  ? 806 ALA A O     1 
ATOM 4265 C CB    . ALA A 1 812 ? 112.805 147.998 92.378  1.00 64.68  ? 806 ALA A CB    1 
ATOM 4266 N N     . SER A 1 813 ? 109.776 147.844 92.903  1.00 69.16  ? 807 SER A N     1 
ATOM 4267 C CA    . SER A 1 813 ? 108.433 147.493 92.467  1.00 66.16  ? 807 SER A CA    1 
ATOM 4268 C C     . SER A 1 813 ? 108.065 148.335 91.254  1.00 64.52  ? 807 SER A C     1 
ATOM 4269 O O     . SER A 1 813 ? 108.500 149.482 91.123  1.00 64.13  ? 807 SER A O     1 
ATOM 4270 C CB    . SER A 1 813 ? 107.403 147.704 93.583  1.00 64.58  ? 807 SER A CB    1 
ATOM 4271 O OG    . SER A 1 813 ? 107.474 149.020 94.098  1.00 67.64  ? 807 SER A OG    1 
ATOM 4272 N N     . LEU A 1 814 ? 107.250 147.757 90.374  1.00 71.71  ? 808 LEU A N     1 
ATOM 4273 C CA    . LEU A 1 814 ? 106.858 148.424 89.137  1.00 74.47  ? 808 LEU A CA    1 
ATOM 4274 C C     . LEU A 1 814 ? 105.660 149.328 89.398  1.00 76.16  ? 808 LEU A C     1 
ATOM 4275 O O     . LEU A 1 814 ? 104.576 148.846 89.740  1.00 76.01  ? 808 LEU A O     1 
ATOM 4276 C CB    . LEU A 1 814 ? 106.523 147.391 88.061  1.00 74.81  ? 808 LEU A CB    1 
ATOM 4277 C CG    . LEU A 1 814 ? 106.173 147.868 86.648  1.00 71.40  ? 808 LEU A CG    1 
ATOM 4278 C CD1   . LEU A 1 814 ? 106.909 149.150 86.283  1.00 68.43  ? 808 LEU A CD1   1 
ATOM 4279 C CD2   . LEU A 1 814 ? 106.466 146.774 85.634  1.00 70.83  ? 808 LEU A CD2   1 
ATOM 4280 N N     . LEU A 1 815 ? 105.855 150.637 89.236  1.00 80.92  ? 809 LEU A N     1 
ATOM 4281 C CA    . LEU A 1 815 ? 104.745 151.573 89.385  1.00 80.56  ? 809 LEU A CA    1 
ATOM 4282 C C     . LEU A 1 815 ? 103.929 151.667 88.099  1.00 82.83  ? 809 LEU A C     1 
ATOM 4283 O O     . LEU A 1 815 ? 102.751 151.295 88.071  1.00 83.54  ? 809 LEU A O     1 
ATOM 4284 C CB    . LEU A 1 815 ? 105.273 152.950 89.792  1.00 76.80  ? 809 LEU A CB    1 
ATOM 4285 C CG    . LEU A 1 815 ? 104.409 153.739 90.778  1.00 78.28  ? 809 LEU A CG    1 
ATOM 4286 C CD1   . LEU A 1 815 ? 104.152 152.920 92.031  1.00 77.74  ? 809 LEU A CD1   1 
ATOM 4287 C CD2   . LEU A 1 815 ? 105.068 155.064 91.121  1.00 79.68  ? 809 LEU A CD2   1 
ATOM 4288 N N     . ASP A 1 816 ? 104.551 152.145 87.023  1.00 89.22  ? 810 ASP A N     1 
ATOM 4289 C CA    . ASP A 1 816 ? 103.931 152.274 85.708  1.00 88.31  ? 810 ASP A CA    1 
ATOM 4290 C C     . ASP A 1 816 ? 104.981 152.780 84.731  1.00 89.06  ? 810 ASP A C     1 
ATOM 4291 O O     . ASP A 1 816 ? 106.014 153.327 85.132  1.00 90.34  ? 810 ASP A O     1 
ATOM 4292 C CB    . ASP A 1 816 ? 102.724 153.221 85.722  1.00 86.43  ? 810 ASP A CB    1 
ATOM 4293 C CG    . ASP A 1 816 ? 102.971 154.466 86.547  1.00 90.99  ? 810 ASP A CG    1 
ATOM 4294 O OD1   . ASP A 1 816 ? 103.549 155.434 86.013  1.00 92.03  ? 810 ASP A OD1   1 
ATOM 4295 O OD2   . ASP A 1 816 ? 102.585 154.481 87.736  1.00 89.54  ? 810 ASP A OD2   1 
ATOM 4296 N N     . ASP A 1 817 ? 104.692 152.601 83.440  1.00 87.71  ? 811 ASP A N     1 
ATOM 4297 C CA    . ASP A 1 817 ? 105.553 153.051 82.345  1.00 88.53  ? 811 ASP A CA    1 
ATOM 4298 C C     . ASP A 1 817 ? 106.944 152.430 82.542  1.00 92.15  ? 811 ASP A C     1 
ATOM 4299 O O     . ASP A 1 817 ? 107.983 153.088 82.489  1.00 94.08  ? 811 ASP A O     1 
ATOM 4300 C CB    . ASP A 1 817 ? 105.565 154.593 82.280  1.00 90.08  ? 811 ASP A CB    1 
ATOM 4301 C CG    . ASP A 1 817 ? 106.634 155.190 81.343  1.00 92.19  ? 811 ASP A CG    1 
ATOM 4302 O OD1   . ASP A 1 817 ? 107.325 154.465 80.597  1.00 93.44  ? 811 ASP A OD1   1 
ATOM 4303 O OD2   . ASP A 1 817 ? 106.789 156.430 81.375  1.00 91.11  ? 811 ASP A OD2   1 
ATOM 4304 N N     . GLY A 1 818 ? 106.943 151.142 82.877  1.00 87.41  ? 812 GLY A N     1 
ATOM 4305 C CA    . GLY A 1 818 ? 108.174 150.386 83.012  1.00 85.82  ? 812 GLY A CA    1 
ATOM 4306 C C     . GLY A 1 818 ? 109.149 150.925 84.041  1.00 86.77  ? 812 GLY A C     1 
ATOM 4307 O O     . GLY A 1 818 ? 110.332 150.575 84.023  1.00 86.37  ? 812 GLY A O     1 
ATOM 4308 N N     . ARG A 1 819 ? 108.668 151.776 84.942  1.00 84.83  ? 813 ARG A N     1 
ATOM 4309 C CA    . ARG A 1 819 ? 109.516 152.422 85.939  1.00 82.30  ? 813 ARG A CA    1 
ATOM 4310 C C     . ARG A 1 819 ? 109.433 151.635 87.240  1.00 86.47  ? 813 ARG A C     1 
ATOM 4311 O O     . ARG A 1 819 ? 108.376 151.583 87.878  1.00 85.91  ? 813 ARG A O     1 
ATOM 4312 C CB    . ARG A 1 819 ? 109.096 153.875 86.145  1.00 80.66  ? 813 ARG A CB    1 
ATOM 4313 C CG    . ARG A 1 819 ? 109.202 154.727 84.892  1.00 82.35  ? 813 ARG A CG    1 
ATOM 4314 C CD    . ARG A 1 819 ? 109.416 156.192 85.220  1.00 86.17  ? 813 ARG A CD    1 
ATOM 4315 N NE    . ARG A 1 819 ? 108.686 156.597 86.414  1.00 86.74  ? 813 ARG A NE    1 
ATOM 4316 C CZ    . ARG A 1 819 ? 108.742 157.810 86.945  1.00 84.36  ? 813 ARG A CZ    1 
ATOM 4317 N NH1   . ARG A 1 819 ? 109.494 158.761 86.414  1.00 83.57  ? 813 ARG A NH1   1 
ATOM 4318 N NH2   . ARG A 1 819 ? 108.023 158.076 88.031  1.00 80.78  ? 813 ARG A NH2   1 
ATOM 4319 N N     . TYR A 1 820 ? 110.548 151.027 87.635  1.00 76.71  ? 814 TYR A N     1 
ATOM 4320 C CA    . TYR A 1 820 ? 110.629 150.252 88.871  1.00 72.39  ? 814 TYR A CA    1 
ATOM 4321 C C     . TYR A 1 820 ? 111.089 151.178 89.990  1.00 70.76  ? 814 TYR A C     1 
ATOM 4322 O O     . TYR A 1 820 ? 112.263 151.544 90.065  1.00 71.17  ? 814 TYR A O     1 
ATOM 4323 C CB    . TYR A 1 820 ? 111.580 149.073 88.703  1.00 71.10  ? 814 TYR A CB    1 
ATOM 4324 C CG    . TYR A 1 820 ? 110.945 147.837 88.108  1.00 69.52  ? 814 TYR A CG    1 
ATOM 4325 C CD1   . TYR A 1 820 ? 110.186 146.980 88.892  1.00 70.14  ? 814 TYR A CD1   1 
ATOM 4326 C CD2   . TYR A 1 820 ? 111.107 147.529 86.765  1.00 65.75  ? 814 TYR A CD2   1 
ATOM 4327 C CE1   . TYR A 1 820 ? 109.609 145.849 88.354  1.00 68.51  ? 814 TYR A CE1   1 
ATOM 4328 C CE2   . TYR A 1 820 ? 110.529 146.400 86.219  1.00 68.99  ? 814 TYR A CE2   1 
ATOM 4329 C CZ    . TYR A 1 820 ? 109.781 145.564 87.017  1.00 70.86  ? 814 TYR A CZ    1 
ATOM 4330 O OH    . TYR A 1 820 ? 109.204 144.439 86.477  1.00 72.85  ? 814 TYR A OH    1 
ATOM 4331 N N     . LEU A 1 821 ? 110.163 151.554 90.868  1.00 61.91  ? 815 LEU A N     1 
ATOM 4332 C CA    . LEU A 1 821 ? 110.509 152.402 92.000  1.00 61.27  ? 815 LEU A CA    1 
ATOM 4333 C C     . LEU A 1 821 ? 111.324 151.610 93.015  1.00 63.87  ? 815 LEU A C     1 
ATOM 4334 O O     . LEU A 1 821 ? 110.946 150.498 93.395  1.00 65.57  ? 815 LEU A O     1 
ATOM 4335 C CB    . LEU A 1 821 ? 109.245 152.958 92.651  1.00 61.97  ? 815 LEU A CB    1 
ATOM 4336 C CG    . LEU A 1 821 ? 109.437 154.051 93.703  1.00 62.47  ? 815 LEU A CG    1 
ATOM 4337 C CD1   . LEU A 1 821 ? 109.510 155.418 93.047  1.00 63.10  ? 815 LEU A CD1   1 
ATOM 4338 C CD2   . LEU A 1 821 ? 108.319 154.006 94.728  1.00 61.69  ? 815 LEU A CD2   1 
ATOM 4339 N N     . VAL A 1 822 ? 112.435 152.186 93.463  1.00 63.26  ? 816 VAL A N     1 
ATOM 4340 C CA    . VAL A 1 822 ? 113.322 151.507 94.400  1.00 62.49  ? 816 VAL A CA    1 
ATOM 4341 C C     . VAL A 1 822 ? 112.737 151.604 95.800  1.00 63.37  ? 816 VAL A C     1 
ATOM 4342 O O     . VAL A 1 822 ? 112.386 152.694 96.268  1.00 65.18  ? 816 VAL A O     1 
ATOM 4343 C CB    . VAL A 1 822 ? 114.736 152.105 94.345  1.00 64.96  ? 816 VAL A CB    1 
ATOM 4344 C CG1   . VAL A 1 822 ? 115.449 151.919 95.676  1.00 65.28  ? 816 VAL A CG1   1 
ATOM 4345 C CG2   . VAL A 1 822 ? 115.534 151.472 93.224  1.00 63.94  ? 816 VAL A CG2   1 
ATOM 4346 N N     . ASN A 1 823 ? 112.629 150.462 96.474  1.00 70.40  ? 817 ASN A N     1 
ATOM 4347 C CA    . ASN A 1 823 ? 112.124 150.407 97.842  1.00 73.88  ? 817 ASN A CA    1 
ATOM 4348 C C     . ASN A 1 823 ? 113.300 150.581 98.795  1.00 77.08  ? 817 ASN A C     1 
ATOM 4349 O O     . ASN A 1 823 ? 114.223 149.761 98.809  1.00 79.01  ? 817 ASN A O     1 
ATOM 4350 C CB    . ASN A 1 823 ? 111.398 149.089 98.094  1.00 72.59  ? 817 ASN A CB    1 
ATOM 4351 C CG    . ASN A 1 823 ? 110.692 149.062 99.431  1.00 76.62  ? 817 ASN A CG    1 
ATOM 4352 O OD1   . ASN A 1 823 ? 110.935 148.182 100.258 1.00 73.83  ? 817 ASN A OD1   1 
ATOM 4353 N ND2   . ASN A 1 823 ? 109.811 150.029 99.654  1.00 77.50  ? 817 ASN A ND2   1 
ATOM 4354 N N     . VAL A 1 824 ? 113.269 151.647 99.587  1.00 73.52  ? 818 VAL A N     1 
ATOM 4355 C CA    . VAL A 1 824 ? 114.343 151.963 100.520 1.00 71.26  ? 818 VAL A CA    1 
ATOM 4356 C C     . VAL A 1 824 ? 113.849 151.653 101.926 1.00 69.27  ? 818 VAL A C     1 
ATOM 4357 O O     . VAL A 1 824 ? 112.935 152.312 102.436 1.00 72.53  ? 818 VAL A O     1 
ATOM 4358 C CB    . VAL A 1 824 ? 114.789 153.425 100.396 1.00 69.88  ? 818 VAL A CB    1 
ATOM 4359 C CG1   . VAL A 1 824 ? 115.656 153.814 101.583 1.00 70.30  ? 818 VAL A CG1   1 
ATOM 4360 C CG2   . VAL A 1 824 ? 115.534 153.641 99.094  1.00 68.50  ? 818 VAL A CG2   1 
ATOM 4361 N N     . THR A 1 825 ? 114.446 150.643 102.552 1.00 74.48  ? 819 THR A N     1 
ATOM 4362 C CA    . THR A 1 825 ? 114.188 150.319 103.948 1.00 76.52  ? 819 THR A CA    1 
ATOM 4363 C C     . THR A 1 825 ? 115.444 150.412 104.798 1.00 79.56  ? 819 THR A C     1 
ATOM 4364 O O     . THR A 1 825 ? 115.424 151.043 105.861 1.00 80.82  ? 819 THR A O     1 
ATOM 4365 C CB    . THR A 1 825 ? 113.579 148.911 104.064 1.00 77.45  ? 819 THR A CB    1 
ATOM 4366 O OG1   . THR A 1 825 ? 112.333 148.866 103.358 1.00 77.87  ? 819 THR A OG1   1 
ATOM 4367 C CG2   . THR A 1 825 ? 113.345 148.547 105.521 1.00 75.37  ? 819 THR A CG2   1 
ATOM 4368 N N     . ARG A 1 826 ? 116.539 149.804 104.353 1.00 75.09  ? 820 ARG A N     1 
ATOM 4369 C CA    . ARG A 1 826 ? 117.796 149.866 105.080 1.00 72.42  ? 820 ARG A CA    1 
ATOM 4370 C C     . ARG A 1 826 ? 118.483 151.205 104.845 1.00 75.23  ? 820 ARG A C     1 
ATOM 4371 O O     . ARG A 1 826 ? 118.299 151.850 103.809 1.00 76.01  ? 820 ARG A O     1 
ATOM 4372 C CB    . ARG A 1 826 ? 118.715 148.721 104.654 1.00 71.94  ? 820 ARG A CB    1 
ATOM 4373 C CG    . ARG A 1 826 ? 118.091 147.343 104.815 1.00 73.73  ? 820 ARG A CG    1 
ATOM 4374 C CD    . ARG A 1 826 ? 119.135 146.236 104.884 1.00 73.46  ? 820 ARG A CD    1 
ATOM 4375 N NE    . ARG A 1 826 ? 120.429 146.635 104.341 1.00 75.69  ? 820 ARG A NE    1 
ATOM 4376 C CZ    . ARG A 1 826 ? 120.783 146.499 103.070 1.00 76.73  ? 820 ARG A CZ    1 
ATOM 4377 N NH1   . ARG A 1 826 ? 119.962 145.972 102.176 1.00 79.22  ? 820 ARG A NH1   1 
ATOM 4378 N NH2   . ARG A 1 826 ? 121.992 146.898 102.687 1.00 72.70  ? 820 ARG A NH2   1 
ATOM 4379 N N     . GLN A 1 827 ? 119.278 151.627 105.830 1.00 71.85  ? 821 GLN A N     1 
ATOM 4380 C CA    . GLN A 1 827 ? 120.060 152.848 105.686 1.00 68.44  ? 821 GLN A CA    1 
ATOM 4381 C C     . GLN A 1 827 ? 121.195 152.691 104.684 1.00 66.66  ? 821 GLN A C     1 
ATOM 4382 O O     . GLN A 1 827 ? 121.604 153.681 104.069 1.00 67.54  ? 821 GLN A O     1 
ATOM 4383 C CB    . GLN A 1 827 ? 120.616 153.282 107.045 1.00 66.40  ? 821 GLN A CB    1 
ATOM 4384 C CG    . GLN A 1 827 ? 121.383 154.593 107.018 1.00 68.18  ? 821 GLN A CG    1 
ATOM 4385 C CD    . GLN A 1 827 ? 121.168 155.421 108.268 1.00 72.61  ? 821 GLN A CD    1 
ATOM 4386 O OE1   . GLN A 1 827 ? 120.524 156.469 108.228 1.00 74.63  ? 821 GLN A OE1   1 
ATOM 4387 N NE2   . GLN A 1 827 ? 121.706 154.954 109.387 1.00 72.52  ? 821 GLN A NE2   1 
ATOM 4388 N N     . HIS A 1 828 ? 121.702 151.470 104.501 1.00 62.40  ? 822 HIS A N     1 
ATOM 4389 C CA    . HIS A 1 828 ? 122.768 151.247 103.531 1.00 63.71  ? 822 HIS A CA    1 
ATOM 4390 C C     . HIS A 1 828 ? 122.294 151.538 102.113 1.00 69.31  ? 822 HIS A C     1 
ATOM 4391 O O     . HIS A 1 828 ? 123.048 152.091 101.304 1.00 69.21  ? 822 HIS A O     1 
ATOM 4392 C CB    . HIS A 1 828 ? 123.282 149.814 103.647 1.00 57.21  ? 822 HIS A CB    1 
ATOM 4393 C CG    . HIS A 1 828 ? 124.122 149.572 104.862 1.00 63.56  ? 822 HIS A CG    1 
ATOM 4394 N ND1   . HIS A 1 828 ? 123.819 148.605 105.797 1.00 63.63  ? 822 HIS A ND1   1 
ATOM 4395 C CD2   . HIS A 1 828 ? 125.256 150.170 105.297 1.00 66.04  ? 822 HIS A CD2   1 
ATOM 4396 C CE1   . HIS A 1 828 ? 124.728 148.619 106.754 1.00 64.51  ? 822 HIS A CE1   1 
ATOM 4397 N NE2   . HIS A 1 828 ? 125.611 149.559 106.473 1.00 65.86  ? 822 HIS A NE2   1 
ATOM 4398 N N     . GLU A 1 829 ? 121.052 151.166 101.791 1.00 73.62  ? 823 GLU A N     1 
ATOM 4399 C CA    . GLU A 1 829 ? 120.500 151.498 100.481 1.00 65.77  ? 823 GLU A CA    1 
ATOM 4400 C C     . GLU A 1 829 ? 120.361 153.004 100.307 1.00 70.70  ? 823 GLU A C     1 
ATOM 4401 O O     . GLU A 1 829 ? 120.611 153.534 99.218  1.00 71.66  ? 823 GLU A O     1 
ATOM 4402 C CB    . GLU A 1 829 ? 119.149 150.812 100.286 1.00 63.08  ? 823 GLU A CB    1 
ATOM 4403 C CG    . GLU A 1 829 ? 119.178 149.312 100.497 1.00 68.52  ? 823 GLU A CG    1 
ATOM 4404 C CD    . GLU A 1 829 ? 117.848 148.659 100.182 1.00 73.39  ? 823 GLU A CD    1 
ATOM 4405 O OE1   . GLU A 1 829 ? 116.882 148.880 100.940 1.00 75.53  ? 823 GLU A OE1   1 
ATOM 4406 O OE2   . GLU A 1 829 ? 117.770 147.924 99.176  1.00 73.60  ? 823 GLU A OE2   1 
ATOM 4407 N N     . ARG A 1 830 ? 119.955 153.709 101.365 1.00 70.96  ? 824 ARG A N     1 
ATOM 4408 C CA    . ARG A 1 830 ? 119.829 155.160 101.290 1.00 69.56  ? 824 ARG A CA    1 
ATOM 4409 C C     . ARG A 1 830 ? 121.175 155.812 100.998 1.00 70.23  ? 824 ARG A C     1 
ATOM 4410 O O     . ARG A 1 830 ? 121.267 156.736 100.184 1.00 72.56  ? 824 ARG A O     1 
ATOM 4411 C CB    . ARG A 1 830 ? 119.241 155.700 102.592 1.00 68.28  ? 824 ARG A CB    1 
ATOM 4412 C CG    . ARG A 1 830 ? 118.613 157.075 102.468 1.00 68.11  ? 824 ARG A CG    1 
ATOM 4413 C CD    . ARG A 1 830 ? 117.985 157.514 103.780 1.00 71.57  ? 824 ARG A CD    1 
ATOM 4414 N NE    . ARG A 1 830 ? 117.334 156.409 104.473 1.00 73.56  ? 824 ARG A NE    1 
ATOM 4415 C CZ    . ARG A 1 830 ? 116.065 156.065 104.306 1.00 73.64  ? 824 ARG A CZ    1 
ATOM 4416 N NH1   . ARG A 1 830 ? 115.277 156.716 103.467 1.00 73.69  ? 824 ARG A NH1   1 
ATOM 4417 N NH2   . ARG A 1 830 ? 115.573 155.041 104.998 1.00 69.78  ? 824 ARG A NH2   1 
ATOM 4418 N N     . ALA A 1 831 ? 122.232 155.342 101.663 1.00 68.01  ? 825 ALA A N     1 
ATOM 4419 C CA    . ALA A 1 831 ? 123.567 155.878 101.413 1.00 64.91  ? 825 ALA A CA    1 
ATOM 4420 C C     . ALA A 1 831 ? 124.033 155.553 100.001 1.00 62.02  ? 825 ALA A C     1 
ATOM 4421 O O     . ALA A 1 831 ? 124.678 156.374 99.341  1.00 63.34  ? 825 ALA A O     1 
ATOM 4422 C CB    . ALA A 1 831 ? 124.551 155.333 102.447 1.00 66.07  ? 825 ALA A CB    1 
ATOM 4423 N N     . TYR A 1 832 ? 123.725 154.344 99.525  1.00 62.40  ? 826 TYR A N     1 
ATOM 4424 C CA    . TYR A 1 832 ? 124.148 153.941 98.187  1.00 63.84  ? 826 TYR A CA    1 
ATOM 4425 C C     . TYR A 1 832 ? 123.488 154.794 97.112  1.00 68.31  ? 826 TYR A C     1 
ATOM 4426 O O     . TYR A 1 832 ? 124.138 155.192 96.140  1.00 72.03  ? 826 TYR A O     1 
ATOM 4427 C CB    . TYR A 1 832 ? 123.831 152.466 97.962  1.00 65.05  ? 826 TYR A CB    1 
ATOM 4428 C CG    . TYR A 1 832 ? 124.050 152.003 96.543  1.00 65.14  ? 826 TYR A CG    1 
ATOM 4429 C CD1   . TYR A 1 832 ? 125.328 151.921 96.008  1.00 60.68  ? 826 TYR A CD1   1 
ATOM 4430 C CD2   . TYR A 1 832 ? 122.980 151.646 95.738  1.00 62.76  ? 826 TYR A CD2   1 
ATOM 4431 C CE1   . TYR A 1 832 ? 125.530 151.497 94.713  1.00 63.73  ? 826 TYR A CE1   1 
ATOM 4432 C CE2   . TYR A 1 832 ? 123.172 151.221 94.440  1.00 60.15  ? 826 TYR A CE2   1 
ATOM 4433 C CZ    . TYR A 1 832 ? 124.450 151.150 93.933  1.00 62.11  ? 826 TYR A CZ    1 
ATOM 4434 O OH    . TYR A 1 832 ? 124.645 150.727 92.641  1.00 62.68  ? 826 TYR A OH    1 
ATOM 4435 N N     . LEU A 1 833 ? 122.191 155.072 97.264  1.00 64.15  ? 827 LEU A N     1 
ATOM 4436 C CA    . LEU A 1 833 ? 121.484 155.857 96.259  1.00 60.91  ? 827 LEU A CA    1 
ATOM 4437 C C     . LEU A 1 833 ? 122.029 157.276 96.183  1.00 64.05  ? 827 LEU A C     1 
ATOM 4438 O O     . LEU A 1 833 ? 122.087 157.870 95.100  1.00 66.04  ? 827 LEU A O     1 
ATOM 4439 C CB    . LEU A 1 833 ? 119.987 155.868 96.562  1.00 59.21  ? 827 LEU A CB    1 
ATOM 4440 C CG    . LEU A 1 833 ? 119.239 154.583 96.207  1.00 63.48  ? 827 LEU A CG    1 
ATOM 4441 C CD1   . LEU A 1 833 ? 117.750 154.747 96.443  1.00 62.42  ? 827 LEU A CD1   1 
ATOM 4442 C CD2   . LEU A 1 833 ? 119.511 154.192 94.768  1.00 65.81  ? 827 LEU A CD2   1 
ATOM 4443 N N     . GLU A 1 834 ? 122.433 157.838 97.324  1.00 64.10  ? 828 GLU A N     1 
ATOM 4444 C CA    . GLU A 1 834 ? 122.980 159.189 97.333  1.00 66.89  ? 828 GLU A CA    1 
ATOM 4445 C C     . GLU A 1 834 ? 124.291 159.263 96.559  1.00 69.51  ? 828 GLU A C     1 
ATOM 4446 O O     . GLU A 1 834 ? 124.546 160.239 95.846  1.00 71.30  ? 828 GLU A O     1 
ATOM 4447 C CB    . GLU A 1 834 ? 123.182 159.663 98.771  1.00 64.52  ? 828 GLU A CB    1 
ATOM 4448 C CG    . GLU A 1 834 ? 121.905 160.104 99.463  1.00 69.09  ? 828 GLU A CG    1 
ATOM 4449 C CD    . GLU A 1 834 ? 122.160 160.685 100.839 1.00 72.98  ? 828 GLU A CD    1 
ATOM 4450 O OE1   . GLU A 1 834 ? 123.228 161.300 101.038 1.00 71.28  ? 828 GLU A OE1   1 
ATOM 4451 O OE2   . GLU A 1 834 ? 121.293 160.527 101.724 1.00 72.83  ? 828 GLU A OE2   1 
ATOM 4452 N N     . LEU A 1 835 ? 125.136 158.238 96.687  1.00 62.06  ? 829 LEU A N     1 
ATOM 4453 C CA    . LEU A 1 835 ? 126.459 158.294 96.075  1.00 60.31  ? 829 LEU A CA    1 
ATOM 4454 C C     . LEU A 1 835 ? 126.404 158.093 94.566  1.00 62.73  ? 829 LEU A C     1 
ATOM 4455 O O     . LEU A 1 835 ? 127.235 158.653 93.842  1.00 64.72  ? 829 LEU A O     1 
ATOM 4456 C CB    . LEU A 1 835 ? 127.373 157.252 96.715  1.00 61.53  ? 829 LEU A CB    1 
ATOM 4457 C CG    . LEU A 1 835 ? 127.893 157.607 98.107  1.00 63.55  ? 829 LEU A CG    1 
ATOM 4458 C CD1   . LEU A 1 835 ? 127.992 156.366 98.970  1.00 60.54  ? 829 LEU A CD1   1 
ATOM 4459 C CD2   . LEU A 1 835 ? 129.237 158.308 98.013  1.00 63.74  ? 829 LEU A CD2   1 
ATOM 4460 N N     . GLN A 1 836 ? 125.449 157.307 94.073  1.00 64.04  ? 830 GLN A N     1 
ATOM 4461 C CA    . GLN A 1 836 ? 125.361 157.029 92.642  1.00 65.75  ? 830 GLN A CA    1 
ATOM 4462 C C     . GLN A 1 836 ? 124.427 158.006 91.934  1.00 69.21  ? 830 GLN A C     1 
ATOM 4463 O O     . GLN A 1 836 ? 124.839 158.711 91.009  1.00 72.47  ? 830 GLN A O     1 
ATOM 4464 C CB    . GLN A 1 836 ? 124.903 155.584 92.415  1.00 63.73  ? 830 GLN A CB    1 
ATOM 4465 C CG    . GLN A 1 836 ? 125.840 154.543 92.996  1.00 67.96  ? 830 GLN A CG    1 
ATOM 4466 C CD    . GLN A 1 836 ? 126.891 154.084 92.008  1.00 66.89  ? 830 GLN A CD    1 
ATOM 4467 O OE1   . GLN A 1 836 ? 128.074 154.386 92.158  1.00 64.52  ? 830 GLN A OE1   1 
ATOM 4468 N NE2   . GLN A 1 836 ? 126.465 153.344 90.991  1.00 64.53  ? 830 GLN A NE2   1 
ATOM 4469 N N     . THR A 1 837 ? 123.165 158.056 92.360  1.00 66.70  ? 831 THR A N     1 
ATOM 4470 C CA    . THR A 1 837 ? 122.201 158.945 91.721  1.00 65.05  ? 831 THR A CA    1 
ATOM 4471 C C     . THR A 1 837 ? 122.389 160.386 92.182  1.00 64.62  ? 831 THR A C     1 
ATOM 4472 O O     . THR A 1 837 ? 122.662 161.278 91.373  1.00 66.63  ? 831 THR A O     1 
ATOM 4473 C CB    . THR A 1 837 ? 120.775 158.470 92.012  1.00 68.23  ? 831 THR A CB    1 
ATOM 4474 O OG1   . THR A 1 837 ? 120.315 159.065 93.233  1.00 69.88  ? 831 THR A OG1   1 
ATOM 4475 C CG2   . THR A 1 837 ? 120.734 156.959 92.146  1.00 69.84  ? 831 THR A CG2   1 
ATOM 4476 N N     . GLY A 1 838 ? 122.251 160.626 93.483  1.00 63.24  ? 832 GLY A N     1 
ATOM 4477 C CA    . GLY A 1 838 ? 122.342 161.968 94.019  1.00 65.44  ? 832 GLY A CA    1 
ATOM 4478 C C     . GLY A 1 838 ? 121.152 162.315 94.889  1.00 65.24  ? 832 GLY A C     1 
ATOM 4479 O O     . GLY A 1 838 ? 121.103 163.389 95.494  1.00 66.52  ? 832 GLY A O     1 
ATOM 4480 N N     . ALA A 1 839 ? 120.191 161.406 94.956  1.00 64.43  ? 833 ALA A N     1 
ATOM 4481 C CA    . ALA A 1 839 ? 118.974 161.559 95.732  1.00 65.61  ? 833 ALA A CA    1 
ATOM 4482 C C     . ALA A 1 839 ? 118.726 160.291 96.532  1.00 67.00  ? 833 ALA A C     1 
ATOM 4483 O O     . ALA A 1 839 ? 119.193 159.210 96.158  1.00 71.39  ? 833 ALA A O     1 
ATOM 4484 C CB    . ALA A 1 839 ? 117.773 161.848 94.821  1.00 67.00  ? 833 ALA A CB    1 
ATOM 4485 N N     . PRO A 1 840 ? 117.988 160.387 97.644  1.00 69.92  ? 834 PRO A N     1 
ATOM 4486 C CA    . PRO A 1 840 ? 117.726 159.189 98.454  1.00 71.34  ? 834 PRO A CA    1 
ATOM 4487 C C     . PRO A 1 840 ? 116.678 158.266 97.851  1.00 73.19  ? 834 PRO A C     1 
ATOM 4488 O O     . PRO A 1 840 ? 116.190 157.353 98.526  1.00 72.60  ? 834 PRO A O     1 
ATOM 4489 C CB    . PRO A 1 840 ? 117.252 159.771 99.792  1.00 71.04  ? 834 PRO A CB    1 
ATOM 4490 C CG    . PRO A 1 840 ? 116.673 161.091 99.431  1.00 73.12  ? 834 PRO A CG    1 
ATOM 4491 C CD    . PRO A 1 840 ? 117.527 161.615 98.313  1.00 69.27  ? 834 PRO A CD    1 
ATOM 4492 N N     . ALA A 1 841 ? 116.315 158.494 96.592  1.00 75.92  ? 835 ALA A N     1 
ATOM 4493 C CA    . ALA A 1 841 ? 115.383 157.623 95.894  1.00 75.12  ? 835 ALA A CA    1 
ATOM 4494 C C     . ALA A 1 841 ? 115.745 157.597 94.418  1.00 75.34  ? 835 ALA A C     1 
ATOM 4495 O O     . ALA A 1 841 ? 116.368 158.525 93.898  1.00 76.95  ? 835 ALA A O     1 
ATOM 4496 C CB    . ALA A 1 841 ? 113.930 158.076 96.085  1.00 72.11  ? 835 ALA A CB    1 
ATOM 4497 N N     . ALA A 1 842 ? 115.345 156.521 93.746  1.00 68.12  ? 836 ALA A N     1 
ATOM 4498 C CA    . ALA A 1 842 ? 115.627 156.362 92.326  1.00 72.75  ? 836 ALA A CA    1 
ATOM 4499 C C     . ALA A 1 842 ? 114.680 155.317 91.751  1.00 73.38  ? 836 ALA A C     1 
ATOM 4500 O O     . ALA A 1 842 ? 113.990 154.606 92.482  1.00 71.11  ? 836 ALA A O     1 
ATOM 4501 C CB    . ALA A 1 842 ? 117.088 155.970 92.087  1.00 74.92  ? 836 ALA A CB    1 
ATOM 4502 N N     . THR A 1 843 ? 114.650 155.245 90.420  1.00 78.12  ? 837 THR A N     1 
ATOM 4503 C CA    . THR A 1 843 ? 113.832 154.279 89.701  1.00 77.95  ? 837 THR A CA    1 
ATOM 4504 C C     . THR A 1 843 ? 114.668 153.563 88.651  1.00 81.67  ? 837 THR A C     1 
ATOM 4505 O O     . THR A 1 843 ? 115.670 154.093 88.163  1.00 84.45  ? 837 THR A O     1 
ATOM 4506 C CB    . THR A 1 843 ? 112.625 154.931 89.007  1.00 78.82  ? 837 THR A CB    1 
ATOM 4507 O OG1   . THR A 1 843 ? 113.005 155.367 87.696  1.00 82.22  ? 837 THR A OG1   1 
ATOM 4508 C CG2   . THR A 1 843 ? 112.104 156.111 89.799  1.00 76.74  ? 837 THR A CG2   1 
ATOM 4509 N N     . LEU A 1 844 ? 114.241 152.350 88.307  1.00 77.65  ? 838 LEU A N     1 
ATOM 4510 C CA    . LEU A 1 844 ? 114.864 151.573 87.242  1.00 75.71  ? 838 LEU A CA    1 
ATOM 4511 C C     . LEU A 1 844 ? 114.094 151.812 85.949  1.00 77.91  ? 838 LEU A C     1 
ATOM 4512 O O     . LEU A 1 844 ? 112.951 151.366 85.807  1.00 80.41  ? 838 LEU A O     1 
ATOM 4513 C CB    . LEU A 1 844 ? 114.896 150.086 87.591  1.00 76.89  ? 838 LEU A CB    1 
ATOM 4514 C CG    . LEU A 1 844 ? 115.806 149.610 88.727  1.00 76.08  ? 838 LEU A CG    1 
ATOM 4515 C CD1   . LEU A 1 844 ? 117.131 150.353 88.702  1.00 75.23  ? 838 LEU A CD1   1 
ATOM 4516 C CD2   . LEU A 1 844 ? 115.132 149.739 90.082  1.00 75.03  ? 838 LEU A CD2   1 
ATOM 4517 N N     . ASN A 1 845 ? 114.718 152.512 85.005  1.00 81.11  ? 839 ASN A N     1 
ATOM 4518 C CA    . ASN A 1 845 ? 114.095 152.773 83.715  1.00 81.81  ? 839 ASN A CA    1 
ATOM 4519 C C     . ASN A 1 845 ? 114.656 151.829 82.664  1.00 83.11  ? 839 ASN A C     1 
ATOM 4520 O O     . ASN A 1 845 ? 115.879 151.646 82.596  1.00 83.30  ? 839 ASN A O     1 
ATOM 4521 C CB    . ASN A 1 845 ? 114.322 154.220 83.293  1.00 83.31  ? 839 ASN A CB    1 
ATOM 4522 C CG    . ASN A 1 845 ? 113.626 155.203 84.210  1.00 85.24  ? 839 ASN A CG    1 
ATOM 4523 O OD1   . ASN A 1 845 ? 112.425 155.098 84.450  1.00 84.96  ? 839 ASN A OD1   1 
ATOM 4524 N ND2   . ASN A 1 845 ? 114.379 156.163 84.729  1.00 85.73  ? 839 ASN A ND2   1 
ATOM 4525 N N     . PRO A 1 846 ? 113.807 151.225 81.837  1.00 83.55  ? 840 PRO A N     1 
ATOM 4526 C CA    . PRO A 1 846 ? 114.280 150.183 80.920  1.00 83.74  ? 840 PRO A CA    1 
ATOM 4527 C C     . PRO A 1 846 ? 115.173 150.743 79.824  1.00 85.15  ? 840 PRO A C     1 
ATOM 4528 O O     . PRO A 1 846 ? 115.125 151.925 79.475  1.00 84.63  ? 840 PRO A O     1 
ATOM 4529 C CB    . PRO A 1 846 ? 112.985 149.607 80.329  1.00 85.56  ? 840 PRO A CB    1 
ATOM 4530 C CG    . PRO A 1 846 ? 111.871 150.156 81.178  1.00 85.43  ? 840 PRO A CG    1 
ATOM 4531 C CD    . PRO A 1 846 ? 112.363 151.463 81.701  1.00 84.99  ? 840 PRO A CD    1 
ATOM 4532 N N     . THR A 1 847 ? 116.010 149.856 79.284  1.00 86.03  ? 841 THR A N     1 
ATOM 4533 C CA    . THR A 1 847 ? 116.845 150.182 78.136  1.00 87.40  ? 841 THR A CA    1 
ATOM 4534 C C     . THR A 1 847 ? 116.623 149.161 77.026  1.00 88.31  ? 841 THR A C     1 
ATOM 4535 O O     . THR A 1 847 ? 115.723 148.324 77.120  1.00 85.31  ? 841 THR A O     1 
ATOM 4536 C CB    . THR A 1 847 ? 118.322 150.233 78.533  1.00 85.86  ? 841 THR A CB    1 
ATOM 4537 O OG1   . THR A 1 847 ? 119.097 150.736 77.436  1.00 87.24  ? 841 THR A OG1   1 
ATOM 4538 C CG2   . THR A 1 847 ? 118.822 148.852 78.906  1.00 84.47  ? 841 THR A CG2   1 
ATOM 4539 N N     . ALA A 1 848 ? 117.438 149.225 75.970  1.00 93.36  ? 842 ALA A N     1 
ATOM 4540 C CA    . ALA A 1 848 ? 117.225 148.352 74.821  1.00 92.82  ? 842 ALA A CA    1 
ATOM 4541 C C     . ALA A 1 848 ? 117.546 146.897 75.148  1.00 91.56  ? 842 ALA A C     1 
ATOM 4542 O O     . ALA A 1 848 ? 116.801 145.992 74.760  1.00 90.96  ? 842 ALA A O     1 
ATOM 4543 C CB    . ALA A 1 848 ? 118.061 148.833 73.636  1.00 89.50  ? 842 ALA A CB    1 
ATOM 4544 N N     . GLU A 1 849 ? 118.646 146.651 75.856  1.00 89.39  ? 843 GLU A N     1 
ATOM 4545 C CA    . GLU A 1 849 ? 119.115 145.285 76.087  1.00 90.28  ? 843 GLU A CA    1 
ATOM 4546 C C     . GLU A 1 849 ? 118.566 144.695 77.384  1.00 92.84  ? 843 GLU A C     1 
ATOM 4547 O O     . GLU A 1 849 ? 119.310 144.156 78.203  1.00 94.44  ? 843 GLU A O     1 
ATOM 4548 C CB    . GLU A 1 849 ? 120.638 145.257 76.074  1.00 89.54  ? 843 GLU A CB    1 
ATOM 4549 C CG    . GLU A 1 849 ? 121.283 146.521 76.619  1.00 89.17  ? 843 GLU A CG    1 
ATOM 4550 C CD    . GLU A 1 849 ? 121.783 147.439 75.520  1.00 91.53  ? 843 GLU A CD    1 
ATOM 4551 O OE1   . GLU A 1 849 ? 121.024 147.688 74.562  1.00 92.09  ? 843 GLU A OE1   1 
ATOM 4552 O OE2   . GLU A 1 849 ? 122.933 147.914 75.618  1.00 91.26  ? 843 GLU A OE2   1 
ATOM 4553 N N     . ALA A 1 850 ? 117.247 144.790 77.567  1.00 87.53  ? 844 ALA A N     1 
ATOM 4554 C CA    . ALA A 1 850 ? 116.537 144.133 78.671  1.00 87.41  ? 844 ALA A CA    1 
ATOM 4555 C C     . ALA A 1 850 ? 117.138 144.471 80.034  1.00 87.93  ? 844 ALA A C     1 
ATOM 4556 O O     . ALA A 1 850 ? 117.023 143.695 80.986  1.00 84.61  ? 844 ALA A O     1 
ATOM 4557 C CB    . ALA A 1 850 ? 116.495 142.616 78.467  1.00 84.03  ? 844 ALA A CB    1 
ATOM 4558 N N     . SER A 1 851 ? 117.776 145.629 80.142  1.00 89.68  ? 845 SER A N     1 
ATOM 4559 C CA    . SER A 1 851 ? 118.440 146.052 81.367  1.00 85.90  ? 845 SER A CA    1 
ATOM 4560 C C     . SER A 1 851 ? 117.777 147.318 81.900  1.00 85.94  ? 845 SER A C     1 
ATOM 4561 O O     . SER A 1 851 ? 116.812 147.832 81.329  1.00 87.53  ? 845 SER A O     1 
ATOM 4562 C CB    . SER A 1 851 ? 119.935 146.272 81.127  1.00 84.12  ? 845 SER A CB    1 
ATOM 4563 O OG    . SER A 1 851 ? 120.508 145.168 80.451  1.00 87.54  ? 845 SER A OG    1 
ATOM 4564 N N     . TYR A 1 852 ? 118.313 147.824 83.008  1.00 79.90  ? 846 TYR A N     1 
ATOM 4565 C CA    . TYR A 1 852 ? 117.743 149.001 83.651  1.00 78.76  ? 846 TYR A CA    1 
ATOM 4566 C C     . TYR A 1 852 ? 118.845 149.987 84.016  1.00 80.35  ? 846 TYR A C     1 
ATOM 4567 O O     . TYR A 1 852 ? 120.000 149.802 83.621  1.00 82.87  ? 846 TYR A O     1 
ATOM 4568 C CB    . TYR A 1 852 ? 116.940 148.581 84.881  1.00 73.80  ? 846 TYR A CB    1 
ATOM 4569 C CG    . TYR A 1 852 ? 115.602 147.982 84.519  1.00 79.35  ? 846 TYR A CG    1 
ATOM 4570 C CD1   . TYR A 1 852 ? 114.523 148.789 84.188  1.00 84.05  ? 846 TYR A CD1   1 
ATOM 4571 C CD2   . TYR A 1 852 ? 115.426 146.607 84.481  1.00 77.84  ? 846 TYR A CD2   1 
ATOM 4572 C CE1   . TYR A 1 852 ? 113.301 148.243 83.845  1.00 82.37  ? 846 TYR A CE1   1 
ATOM 4573 C CE2   . TYR A 1 852 ? 114.208 146.050 84.139  1.00 79.50  ? 846 TYR A CE2   1 
ATOM 4574 C CZ    . TYR A 1 852 ? 113.150 146.872 83.823  1.00 81.81  ? 846 TYR A CZ    1 
ATOM 4575 O OH    . TYR A 1 852 ? 111.936 146.324 83.481  1.00 77.97  ? 846 TYR A OH    1 
ATOM 4576 N N     . GLU A 1 853 ? 118.502 151.044 84.749  1.00 78.94  ? 847 GLU A N     1 
ATOM 4577 C CA    . GLU A 1 853 ? 119.497 152.024 85.158  1.00 79.76  ? 847 GLU A CA    1 
ATOM 4578 C C     . GLU A 1 853 ? 118.964 152.806 86.347  1.00 82.36  ? 847 GLU A C     1 
ATOM 4579 O O     . GLU A 1 853 ? 117.758 152.843 86.602  1.00 85.58  ? 847 GLU A O     1 
ATOM 4580 C CB    . GLU A 1 853 ? 119.858 152.972 84.007  1.00 77.77  ? 847 GLU A CB    1 
ATOM 4581 C CG    . GLU A 1 853 ? 121.227 152.713 83.401  1.00 80.07  ? 847 GLU A CG    1 
ATOM 4582 C CD    . GLU A 1 853 ? 121.869 153.968 82.847  1.00 85.08  ? 847 GLU A CD    1 
ATOM 4583 O OE1   . GLU A 1 853 ? 121.162 154.752 82.179  1.00 82.82  ? 847 GLU A OE1   1 
ATOM 4584 O OE2   . GLU A 1 853 ? 123.080 154.169 83.077  1.00 88.40  ? 847 GLU A OE2   1 
ATOM 4585 N N     . LEU A 1 854 ? 119.886 153.433 87.076  1.00 71.04  ? 848 LEU A N     1 
ATOM 4586 C CA    . LEU A 1 854 ? 119.537 154.280 88.206  1.00 70.63  ? 848 LEU A CA    1 
ATOM 4587 C C     . LEU A 1 854 ? 119.566 155.741 87.775  1.00 72.52  ? 848 LEU A C     1 
ATOM 4588 O O     . LEU A 1 854 ? 120.547 156.199 87.179  1.00 73.64  ? 848 LEU A O     1 
ATOM 4589 C CB    . LEU A 1 854 ? 120.502 154.053 89.370  1.00 69.85  ? 848 LEU A CB    1 
ATOM 4590 C CG    . LEU A 1 854 ? 120.137 152.951 90.366  1.00 68.32  ? 848 LEU A CG    1 
ATOM 4591 C CD1   . LEU A 1 854 ? 120.970 153.079 91.626  1.00 68.58  ? 848 LEU A CD1   1 
ATOM 4592 C CD2   . LEU A 1 854 ? 118.657 152.995 90.697  1.00 68.80  ? 848 LEU A CD2   1 
ATOM 4593 N N     . VAL A 1 855 ? 118.490 156.468 88.072  1.00 70.42  ? 849 VAL A N     1 
ATOM 4594 C CA    . VAL A 1 855 ? 118.346 157.868 87.676  1.00 76.01  ? 849 VAL A CA    1 
ATOM 4595 C C     . VAL A 1 855 ? 118.297 158.788 88.895  1.00 74.96  ? 849 VAL A C     1 
ATOM 4596 O O     . VAL A 1 855 ? 119.139 159.676 89.046  1.00 72.42  ? 849 VAL A O     1 
ATOM 4597 C CB    . VAL A 1 855 ? 117.111 158.068 86.771  1.00 73.60  ? 849 VAL A CB    1 
ATOM 4598 C CG1   . VAL A 1 855 ? 116.810 159.547 86.603  1.00 73.00  ? 849 VAL A CG1   1 
ATOM 4599 C CG2   . VAL A 1 855 ? 117.341 157.413 85.419  1.00 71.43  ? 849 VAL A CG2   1 
ATOM 4600 N N     . GLY A 1 856 ? 117.325 158.594 89.768  1.00 71.21  ? 850 GLY A N     1 
ATOM 4601 C CA    . GLY A 1 856 ? 117.194 159.444 90.940  1.00 70.80  ? 850 GLY A CA    1 
ATOM 4602 C C     . GLY A 1 856 ? 115.938 160.292 90.862  1.00 72.20  ? 850 GLY A C     1 
ATOM 4603 O O     . GLY A 1 856 ? 115.520 160.725 89.780  1.00 71.41  ? 850 GLY A O     1 
ATOM 4604 N N     . LEU A 1 857 ? 115.330 160.540 92.019  1.00 76.55  ? 851 LEU A N     1 
ATOM 4605 C CA    . LEU A 1 857 ? 114.070 161.268 92.108  1.00 77.66  ? 851 LEU A CA    1 
ATOM 4606 C C     . LEU A 1 857 ? 114.245 162.501 92.981  1.00 80.47  ? 851 LEU A C     1 
ATOM 4607 O O     . LEU A 1 857 ? 114.638 162.391 94.147  1.00 80.93  ? 851 LEU A O     1 
ATOM 4608 C CB    . LEU A 1 857 ? 112.961 160.379 92.669  1.00 77.63  ? 851 LEU A CB    1 
ATOM 4609 C CG    . LEU A 1 857 ? 112.560 159.185 91.807  1.00 77.22  ? 851 LEU A CG    1 
ATOM 4610 C CD1   . LEU A 1 857 ? 111.235 158.620 92.280  1.00 77.27  ? 851 LEU A CD1   1 
ATOM 4611 C CD2   . LEU A 1 857 ? 112.483 159.598 90.346  1.00 75.68  ? 851 LEU A CD2   1 
ATOM 4612 N N     . SER A 1 858 ? 113.942 163.667 92.418  1.00 86.94  ? 852 SER A N     1 
ATOM 4613 C CA    . SER A 1 858 ? 113.888 164.883 93.208  1.00 86.51  ? 852 SER A CA    1 
ATOM 4614 C C     . SER A 1 858 ? 112.677 164.839 94.143  1.00 89.47  ? 852 SER A C     1 
ATOM 4615 O O     . SER A 1 858 ? 111.687 164.163 93.855  1.00 88.27  ? 852 SER A O     1 
ATOM 4616 C CB    . SER A 1 858 ? 113.805 166.103 92.296  1.00 83.29  ? 852 SER A CB    1 
ATOM 4617 O OG    . SER A 1 858 ? 112.774 165.951 91.335  1.00 83.30  ? 852 SER A OG    1 
ATOM 4618 N N     . PRO A 1 859 ? 112.733 165.549 95.280  1.00 88.78  ? 853 PRO A N     1 
ATOM 4619 C CA    . PRO A 1 859 ? 111.589 165.516 96.198  1.00 86.90  ? 853 PRO A CA    1 
ATOM 4620 C C     . PRO A 1 859 ? 110.398 166.311 95.672  1.00 87.29  ? 853 PRO A C     1 
ATOM 4621 O O     . PRO A 1 859 ? 109.506 165.716 95.065  1.00 82.41  ? 853 PRO A O     1 
ATOM 4622 C CB    . PRO A 1 859 ? 112.138 166.147 97.487  1.00 83.96  ? 853 PRO A CB    1 
ATOM 4623 C CG    . PRO A 1 859 ? 113.583 166.468 97.227  1.00 84.78  ? 853 PRO A CG    1 
ATOM 4624 C CD    . PRO A 1 859 ? 113.806 166.434 95.757  1.00 85.45  ? 853 PRO A CD    1 
ATOM 4625 N N     . ARG A 1 874 ? 107.677 144.581 94.782  1.00 75.91  ? 868 ARG A N     1 
ATOM 4626 C CA    . ARG A 1 874 ? 108.820 143.923 95.399  1.00 75.60  ? 868 ARG A CA    1 
ATOM 4627 C C     . ARG A 1 874 ? 109.407 142.860 94.477  1.00 77.26  ? 868 ARG A C     1 
ATOM 4628 O O     . ARG A 1 874 ? 109.029 141.691 94.542  1.00 78.63  ? 868 ARG A O     1 
ATOM 4629 C CB    . ARG A 1 874 ? 108.419 143.294 96.735  1.00 78.00  ? 868 ARG A CB    1 
ATOM 4630 C CG    . ARG A 1 874 ? 108.521 144.237 97.922  1.00 76.77  ? 868 ARG A CG    1 
ATOM 4631 C CD    . ARG A 1 874 ? 107.348 144.053 98.871  1.00 78.97  ? 868 ARG A CD    1 
ATOM 4632 N NE    . ARG A 1 874 ? 106.942 142.656 98.980  1.00 80.45  ? 868 ARG A NE    1 
ATOM 4633 C CZ    . ARG A 1 874 ? 107.221 141.872 100.013 1.00 80.91  ? 868 ARG A CZ    1 
ATOM 4634 N NH1   . ARG A 1 874 ? 107.907 142.315 101.052 1.00 78.84  ? 868 ARG A NH1   1 
ATOM 4635 N NH2   . ARG A 1 874 ? 106.799 140.611 100.001 1.00 76.57  ? 868 ARG A NH2   1 
ATOM 4636 N N     . GLU A 1 875 ? 110.335 143.275 93.615  1.00 72.71  ? 869 GLU A N     1 
ATOM 4637 C CA    . GLU A 1 875 ? 111.005 142.373 92.693  1.00 73.93  ? 869 GLU A CA    1 
ATOM 4638 C C     . GLU A 1 875 ? 112.506 142.623 92.764  1.00 74.52  ? 869 GLU A C     1 
ATOM 4639 O O     . GLU A 1 875 ? 112.949 143.774 92.617  1.00 78.36  ? 869 GLU A O     1 
ATOM 4640 C CB    . GLU A 1 875 ? 110.492 142.564 91.259  1.00 73.90  ? 869 GLU A CB    1 
ATOM 4641 C CG    . GLU A 1 875 ? 109.076 142.055 91.033  1.00 76.91  ? 869 GLU A CG    1 
ATOM 4642 C CD    . GLU A 1 875 ? 108.193 143.067 90.328  1.00 80.33  ? 869 GLU A CD    1 
ATOM 4643 O OE1   . GLU A 1 875 ? 108.097 144.216 90.807  1.00 79.47  ? 869 GLU A OE1   1 
ATOM 4644 O OE2   . GLU A 1 875 ? 107.591 142.713 89.292  1.00 76.62  ? 869 GLU A OE2   1 
ATOM 4645 N N     . PRO A 1 876 ? 113.315 141.592 92.999  1.00 61.39  ? 870 PRO A N     1 
ATOM 4646 C CA    . PRO A 1 876 ? 114.762 141.798 93.112  1.00 59.40  ? 870 PRO A CA    1 
ATOM 4647 C C     . PRO A 1 876 ? 115.391 142.212 91.792  1.00 66.40  ? 870 PRO A C     1 
ATOM 4648 O O     . PRO A 1 876 ? 114.922 141.851 90.711  1.00 75.14  ? 870 PRO A O     1 
ATOM 4649 C CB    . PRO A 1 876 ? 115.283 140.427 93.562  1.00 58.83  ? 870 PRO A CB    1 
ATOM 4650 C CG    . PRO A 1 876 ? 114.075 139.704 94.088  1.00 65.19  ? 870 PRO A CG    1 
ATOM 4651 C CD    . PRO A 1 876 ? 112.933 140.198 93.268  1.00 63.27  ? 870 PRO A CD    1 
ATOM 4652 N N     . PHE A 1 877 ? 116.472 142.982 91.895  1.00 58.61  ? 871 PHE A N     1 
ATOM 4653 C CA    . PHE A 1 877 ? 117.274 143.374 90.744  1.00 57.89  ? 871 PHE A CA    1 
ATOM 4654 C C     . PHE A 1 877 ? 118.745 143.238 91.103  1.00 58.56  ? 871 PHE A C     1 
ATOM 4655 O O     . PHE A 1 877 ? 119.174 143.727 92.152  1.00 59.84  ? 871 PHE A O     1 
ATOM 4656 C CB    . PHE A 1 877 ? 116.971 144.809 90.305  1.00 54.81  ? 871 PHE A CB    1 
ATOM 4657 C CG    . PHE A 1 877 ? 115.649 144.962 89.615  1.00 61.01  ? 871 PHE A CG    1 
ATOM 4658 C CD1   . PHE A 1 877 ? 114.492 145.162 90.346  1.00 60.06  ? 871 PHE A CD1   1 
ATOM 4659 C CD2   . PHE A 1 877 ? 115.562 144.907 88.236  1.00 61.92  ? 871 PHE A CD2   1 
ATOM 4660 C CE1   . PHE A 1 877 ? 113.275 145.301 89.718  1.00 58.99  ? 871 PHE A CE1   1 
ATOM 4661 C CE2   . PHE A 1 877 ? 114.347 145.046 87.601  1.00 63.35  ? 871 PHE A CE2   1 
ATOM 4662 C CZ    . PHE A 1 877 ? 113.202 145.244 88.344  1.00 65.05  ? 871 PHE A CZ    1 
ATOM 4663 N N     . TYR A 1 878 ? 119.511 142.588 90.234  1.00 58.81  ? 872 TYR A N     1 
ATOM 4664 C CA    . TYR A 1 878 ? 120.912 142.289 90.483  1.00 54.51  ? 872 TYR A CA    1 
ATOM 4665 C C     . TYR A 1 878 ? 121.796 143.177 89.617  1.00 59.44  ? 872 TYR A C     1 
ATOM 4666 O O     . TYR A 1 878 ? 121.539 143.345 88.423  1.00 70.93  ? 872 TYR A O     1 
ATOM 4667 C CB    . TYR A 1 878 ? 121.201 140.811 90.213  1.00 53.50  ? 872 TYR A CB    1 
ATOM 4668 C CG    . TYR A 1 878 ? 120.342 139.883 91.040  1.00 54.74  ? 872 TYR A CG    1 
ATOM 4669 C CD1   . TYR A 1 878 ? 119.096 139.469 90.590  1.00 58.19  ? 872 TYR A CD1   1 
ATOM 4670 C CD2   . TYR A 1 878 ? 120.772 139.429 92.276  1.00 60.30  ? 872 TYR A CD2   1 
ATOM 4671 C CE1   . TYR A 1 878 ? 118.309 138.625 91.344  1.00 58.30  ? 872 TYR A CE1   1 
ATOM 4672 C CE2   . TYR A 1 878 ? 119.990 138.585 93.039  1.00 59.03  ? 872 TYR A CE2   1 
ATOM 4673 C CZ    . TYR A 1 878 ? 118.762 138.185 92.568  1.00 56.38  ? 872 TYR A CZ    1 
ATOM 4674 O OH    . TYR A 1 878 ? 117.982 137.345 93.325  1.00 60.66  ? 872 TYR A OH    1 
ATOM 4675 N N     . ARG A 1 879 ? 122.847 143.729 90.229  1.00 53.79  ? 873 ARG A N     1 
ATOM 4676 C CA    . ARG A 1 879 ? 123.586 144.830 89.613  1.00 54.73  ? 873 ARG A CA    1 
ATOM 4677 C C     . ARG A 1 879 ? 124.249 144.412 88.308  1.00 51.75  ? 873 ARG A C     1 
ATOM 4678 O O     . ARG A 1 879 ? 124.054 145.054 87.269  1.00 55.44  ? 873 ARG A O     1 
ATOM 4679 C CB    . ARG A 1 879 ? 124.634 145.362 90.589  1.00 54.53  ? 873 ARG A CB    1 
ATOM 4680 C CG    . ARG A 1 879 ? 125.405 146.558 90.064  1.00 54.82  ? 873 ARG A CG    1 
ATOM 4681 C CD    . ARG A 1 879 ? 126.279 147.166 91.142  1.00 53.66  ? 873 ARG A CD    1 
ATOM 4682 N NE    . ARG A 1 879 ? 127.673 146.778 90.978  1.00 56.55  ? 873 ARG A NE    1 
ATOM 4683 C CZ    . ARG A 1 879 ? 128.251 145.777 91.627  1.00 61.97  ? 873 ARG A CZ    1 
ATOM 4684 N NH1   . ARG A 1 879 ? 127.587 145.050 92.508  1.00 59.21  ? 873 ARG A NH1   1 
ATOM 4685 N NH2   . ARG A 1 879 ? 129.528 145.498 91.384  1.00 61.35  ? 873 ARG A NH2   1 
ATOM 4686 N N     . HIS A 1 880 ? 125.026 143.338 88.340  1.00 55.04  ? 874 HIS A N     1 
ATOM 4687 C CA    . HIS A 1 880 ? 125.841 142.897 87.193  1.00 64.97  ? 874 HIS A CA    1 
ATOM 4688 C C     . HIS A 1 880 ? 126.739 144.070 86.783  1.00 70.08  ? 874 HIS A C     1 
ATOM 4689 O O     . HIS A 1 880 ? 127.274 144.770 87.654  1.00 75.14  ? 874 HIS A O     1 
ATOM 4690 C CB    . HIS A 1 880 ? 124.948 142.351 86.105  1.00 56.59  ? 874 HIS A CB    1 
ATOM 4691 C CG    . HIS A 1 880 ? 124.562 140.923 86.314  1.00 56.41  ? 874 HIS A CG    1 
ATOM 4692 N ND1   . HIS A 1 880 ? 125.355 139.871 85.905  1.00 61.46  ? 874 HIS A ND1   1 
ATOM 4693 C CD2   . HIS A 1 880 ? 123.480 140.369 86.908  1.00 59.48  ? 874 HIS A CD2   1 
ATOM 4694 C CE1   . HIS A 1 880 ? 124.770 138.733 86.230  1.00 67.08  ? 874 HIS A CE1   1 
ATOM 4695 N NE2   . HIS A 1 880 ? 123.632 139.006 86.839  1.00 64.44  ? 874 HIS A NE2   1 
ATOM 4696 N N     . GLU A 1 881 ? 126.927 144.318 85.488  1.00 68.95  ? 875 GLU A N     1 
ATOM 4697 C CA    . GLU A 1 881 ? 127.890 145.317 85.029  1.00 67.31  ? 875 GLU A CA    1 
ATOM 4698 C C     . GLU A 1 881 ? 127.256 146.709 84.977  1.00 72.40  ? 875 GLU A C     1 
ATOM 4699 O O     . GLU A 1 881 ? 127.240 147.387 83.952  1.00 76.87  ? 875 GLU A O     1 
ATOM 4700 C CB    . GLU A 1 881 ? 128.457 144.914 83.673  1.00 72.42  ? 875 GLU A CB    1 
ATOM 4701 C CG    . GLU A 1 881 ? 129.898 145.343 83.454  1.00 71.63  ? 875 GLU A CG    1 
ATOM 4702 C CD    . GLU A 1 881 ? 130.505 144.737 82.206  1.00 77.70  ? 875 GLU A CD    1 
ATOM 4703 O OE1   . GLU A 1 881 ? 129.742 144.386 81.281  1.00 80.23  ? 875 GLU A OE1   1 
ATOM 4704 O OE2   . GLU A 1 881 ? 131.747 144.611 82.147  1.00 75.47  ? 875 GLU A OE2   1 
ATOM 4705 N N     . GLY A 1 882 ? 126.732 147.132 86.126  1.00 73.11  ? 876 GLY A N     1 
ATOM 4706 C CA    . GLY A 1 882 ? 126.176 148.466 86.249  1.00 71.26  ? 876 GLY A CA    1 
ATOM 4707 C C     . GLY A 1 882 ? 124.895 148.704 85.485  1.00 69.91  ? 876 GLY A C     1 
ATOM 4708 O O     . GLY A 1 882 ? 124.574 149.856 85.181  1.00 67.03  ? 876 GLY A O     1 
ATOM 4709 N N     . VAL A 1 883 ? 124.147 147.650 85.165  1.00 65.43  ? 877 VAL A N     1 
ATOM 4710 C CA    . VAL A 1 883 ? 122.918 147.762 84.393  1.00 62.00  ? 877 VAL A CA    1 
ATOM 4711 C C     . VAL A 1 883 ? 121.705 147.219 85.132  1.00 63.88  ? 877 VAL A C     1 
ATOM 4712 O O     . VAL A 1 883 ? 120.583 147.368 84.641  1.00 74.35  ? 877 VAL A O     1 
ATOM 4713 C CB    . VAL A 1 883 ? 123.053 147.075 83.018  1.00 68.89  ? 877 VAL A CB    1 
ATOM 4714 C CG1   . VAL A 1 883 ? 124.387 147.417 82.379  1.00 70.11  ? 877 VAL A CG1   1 
ATOM 4715 C CG2   . VAL A 1 883 ? 122.921 145.576 83.170  1.00 70.40  ? 877 VAL A CG2   1 
ATOM 4716 N N     . TRP A 1 884 ? 121.894 146.586 86.290  1.00 53.28  ? 878 TRP A N     1 
ATOM 4717 C CA    . TRP A 1 884 ? 120.801 146.146 87.160  1.00 56.98  ? 878 TRP A CA    1 
ATOM 4718 C C     . TRP A 1 884 ? 119.850 145.193 86.424  1.00 61.99  ? 878 TRP A C     1 
ATOM 4719 O O     . TRP A 1 884 ? 118.675 145.483 86.197  1.00 69.48  ? 878 TRP A O     1 
ATOM 4720 C CB    . TRP A 1 884 ? 120.044 147.350 87.732  1.00 55.99  ? 878 TRP A CB    1 
ATOM 4721 C CG    . TRP A 1 884 ? 120.813 148.075 88.784  1.00 58.02  ? 878 TRP A CG    1 
ATOM 4722 C CD1   . TRP A 1 884 ? 121.427 149.284 88.662  1.00 63.47  ? 878 TRP A CD1   1 
ATOM 4723 C CD2   . TRP A 1 884 ? 121.061 147.631 90.121  1.00 58.38  ? 878 TRP A CD2   1 
ATOM 4724 N NE1   . TRP A 1 884 ? 122.041 149.624 89.843  1.00 60.53  ? 878 TRP A NE1   1 
ATOM 4725 C CE2   . TRP A 1 884 ? 121.830 148.623 90.754  1.00 59.15  ? 878 TRP A CE2   1 
ATOM 4726 C CE3   . TRP A 1 884 ? 120.706 146.490 90.846  1.00 61.96  ? 878 TRP A CE3   1 
ATOM 4727 C CZ2   . TRP A 1 884 ? 122.251 148.512 92.075  1.00 61.28  ? 878 TRP A CZ2   1 
ATOM 4728 C CZ3   . TRP A 1 884 ? 121.125 146.381 92.156  1.00 58.02  ? 878 TRP A CZ3   1 
ATOM 4729 C CH2   . TRP A 1 884 ? 121.888 147.385 92.758  1.00 58.56  ? 878 TRP A CH2   1 
ATOM 4730 N N     . LEU A 1 885 ? 120.402 144.039 86.057  1.00 60.41  ? 879 LEU A N     1 
ATOM 4731 C CA    . LEU A 1 885 ? 119.602 142.988 85.443  1.00 54.39  ? 879 LEU A CA    1 
ATOM 4732 C C     . LEU A 1 885 ? 118.520 142.502 86.401  1.00 57.67  ? 879 LEU A C     1 
ATOM 4733 O O     . LEU A 1 885 ? 118.710 142.453 87.617  1.00 57.30  ? 879 LEU A O     1 
ATOM 4734 C CB    . LEU A 1 885 ? 120.492 141.813 85.032  1.00 56.58  ? 879 LEU A CB    1 
ATOM 4735 C CG    . LEU A 1 885 ? 121.420 142.008 83.835  1.00 61.86  ? 879 LEU A CG    1 
ATOM 4736 C CD1   . LEU A 1 885 ? 121.847 140.662 83.285  1.00 62.77  ? 879 LEU A CD1   1 
ATOM 4737 C CD2   . LEU A 1 885 ? 120.716 142.811 82.760  1.00 63.40  ? 879 LEU A CD2   1 
ATOM 4738 N N     . THR A 1 886 ? 117.371 142.139 85.835  1.00 68.47  ? 880 THR A N     1 
ATOM 4739 C CA    . THR A 1 886 ? 116.270 141.624 86.635  1.00 70.16  ? 880 THR A CA    1 
ATOM 4740 C C     . THR A 1 886 ? 116.580 140.204 87.103  1.00 68.45  ? 880 THR A C     1 
ATOM 4741 O O     . THR A 1 886 ? 117.657 139.655 86.853  1.00 68.02  ? 880 THR A O     1 
ATOM 4742 C CB    . THR A 1 886 ? 114.966 141.668 85.843  1.00 70.79  ? 880 THR A CB    1 
ATOM 4743 O OG1   . THR A 1 886 ? 113.874 141.311 86.699  1.00 72.29  ? 880 THR A OG1   1 
ATOM 4744 C CG2   . THR A 1 886 ? 115.018 140.698 84.677  1.00 68.18  ? 880 THR A CG2   1 
ATOM 4745 N N     . ARG A 1 887 ? 115.613 139.599 87.795  1.00 62.01  ? 881 ARG A N     1 
ATOM 4746 C CA    . ARG A 1 887 ? 115.839 138.284 88.387  1.00 63.61  ? 881 ARG A CA    1 
ATOM 4747 C C     . ARG A 1 887 ? 116.055 137.220 87.318  1.00 70.66  ? 881 ARG A C     1 
ATOM 4748 O O     . ARG A 1 887 ? 117.009 136.438 87.392  1.00 70.74  ? 881 ARG A O     1 
ATOM 4749 C CB    . ARG A 1 887 ? 114.664 137.910 89.288  1.00 62.55  ? 881 ARG A CB    1 
ATOM 4750 C CG    . ARG A 1 887 ? 114.586 136.430 89.613  1.00 61.35  ? 881 ARG A CG    1 
ATOM 4751 C CD    . ARG A 1 887 ? 115.653 136.040 90.617  1.00 64.11  ? 881 ARG A CD    1 
ATOM 4752 N NE    . ARG A 1 887 ? 115.513 134.657 91.054  1.00 69.03  ? 881 ARG A NE    1 
ATOM 4753 C CZ    . ARG A 1 887 ? 115.235 134.291 92.299  1.00 70.09  ? 881 ARG A CZ    1 
ATOM 4754 N NH1   . ARG A 1 887 ? 115.054 135.185 93.257  1.00 64.25  ? 881 ARG A NH1   1 
ATOM 4755 N NH2   . ARG A 1 887 ? 115.138 132.997 92.588  1.00 70.72  ? 881 ARG A NH2   1 
ATOM 4756 N N     . GLU A 1 888 ? 115.176 137.173 86.315  1.00 78.44  ? 882 GLU A N     1 
ATOM 4757 C CA    . GLU A 1 888 ? 115.296 136.156 85.274  1.00 73.01  ? 882 GLU A CA    1 
ATOM 4758 C C     . GLU A 1 888 ? 116.561 136.351 84.449  1.00 70.29  ? 882 GLU A C     1 
ATOM 4759 O O     . GLU A 1 888 ? 117.247 135.378 84.115  1.00 73.27  ? 882 GLU A O     1 
ATOM 4760 C CB    . GLU A 1 888 ? 114.059 136.172 84.378  1.00 74.16  ? 882 GLU A CB    1 
ATOM 4761 C CG    . GLU A 1 888 ? 112.849 135.474 84.977  1.00 74.21  ? 882 GLU A CG    1 
ATOM 4762 C CD    . GLU A 1 888 ? 112.172 136.293 86.060  1.00 78.05  ? 882 GLU A CD    1 
ATOM 4763 O OE1   . GLU A 1 888 ? 111.918 135.745 87.153  1.00 76.98  ? 882 GLU A OE1   1 
ATOM 4764 O OE2   . GLU A 1 888 ? 111.892 137.486 85.816  1.00 77.95  ? 882 GLU A OE2   1 
ATOM 4765 N N     . LYS A 1 889 ? 116.887 137.601 84.107  1.00 67.78  ? 883 LYS A N     1 
ATOM 4766 C CA    . LYS A 1 889 ? 118.087 137.858 83.319  1.00 70.64  ? 883 LYS A CA    1 
ATOM 4767 C C     . LYS A 1 889 ? 119.355 137.572 84.114  1.00 72.70  ? 883 LYS A C     1 
ATOM 4768 O O     . LYS A 1 889 ? 120.349 137.111 83.542  1.00 73.83  ? 883 LYS A O     1 
ATOM 4769 C CB    . LYS A 1 889 ? 118.087 139.298 82.813  1.00 70.63  ? 883 LYS A CB    1 
ATOM 4770 C CG    . LYS A 1 889 ? 116.953 139.615 81.852  1.00 72.20  ? 883 LYS A CG    1 
ATOM 4771 C CD    . LYS A 1 889 ? 117.255 139.101 80.456  1.00 72.81  ? 883 LYS A CD    1 
ATOM 4772 C CE    . LYS A 1 889 ? 116.062 138.368 79.868  1.00 71.77  ? 883 LYS A CE    1 
ATOM 4773 N NZ    . LYS A 1 889 ? 116.446 137.563 78.675  1.00 69.89  ? 883 LYS A NZ    1 
ATOM 4774 N N     . HIS A 1 890 ? 119.345 137.835 85.421  1.00 63.05  ? 884 HIS A N     1 
ATOM 4775 C CA    . HIS A 1 890 ? 120.499 137.496 86.249  1.00 61.75  ? 884 HIS A CA    1 
ATOM 4776 C C     . HIS A 1 890 ? 120.727 135.990 86.289  1.00 64.41  ? 884 HIS A C     1 
ATOM 4777 O O     . HIS A 1 890 ? 121.866 135.521 86.159  1.00 68.52  ? 884 HIS A O     1 
ATOM 4778 C CB    . HIS A 1 890 ? 120.308 138.054 87.657  1.00 63.73  ? 884 HIS A CB    1 
ATOM 4779 C CG    . HIS A 1 890 ? 121.031 137.287 88.721  1.00 57.85  ? 884 HIS A CG    1 
ATOM 4780 N ND1   . HIS A 1 890 ? 122.406 137.218 88.786  1.00 60.68  ? 884 HIS A ND1   1 
ATOM 4781 C CD2   . HIS A 1 890 ? 120.569 136.565 89.768  1.00 59.70  ? 884 HIS A CD2   1 
ATOM 4782 C CE1   . HIS A 1 890 ? 122.758 136.483 89.825  1.00 66.61  ? 884 HIS A CE1   1 
ATOM 4783 N NE2   . HIS A 1 890 ? 121.662 136.074 90.438  1.00 67.00  ? 884 HIS A NE2   1 
ATOM 4784 N N     . ARG A 1 891 ? 119.653 135.215 86.457  1.00 67.41  ? 885 ARG A N     1 
ATOM 4785 C CA    . ARG A 1 891 ? 119.783 133.763 86.443  1.00 65.70  ? 885 ARG A CA    1 
ATOM 4786 C C     . ARG A 1 891 ? 120.232 133.269 85.075  1.00 67.24  ? 885 ARG A C     1 
ATOM 4787 O O     . ARG A 1 891 ? 121.022 132.323 84.977  1.00 69.10  ? 885 ARG A O     1 
ATOM 4788 C CB    . ARG A 1 891 ? 118.461 133.115 86.845  1.00 66.80  ? 885 ARG A CB    1 
ATOM 4789 C CG    . ARG A 1 891 ? 118.616 131.935 87.787  1.00 67.06  ? 885 ARG A CG    1 
ATOM 4790 C CD    . ARG A 1 891 ? 117.427 131.828 88.738  1.00 65.34  ? 885 ARG A CD    1 
ATOM 4791 N NE    . ARG A 1 891 ? 117.587 132.603 89.966  1.00 65.97  ? 885 ARG A NE    1 
ATOM 4792 C CZ    . ARG A 1 891 ? 118.606 132.512 90.813  1.00 68.37  ? 885 ARG A CZ    1 
ATOM 4793 N NH1   . ARG A 1 891 ? 119.569 131.619 90.652  1.00 71.35  ? 885 ARG A NH1   1 
ATOM 4794 N NH2   . ARG A 1 891 ? 118.646 133.323 91.865  1.00 67.61  ? 885 ARG A NH2   1 
ATOM 4795 N N     . GLU A 1 892 ? 119.742 133.899 84.005  1.00 71.50  ? 886 GLU A N     1 
ATOM 4796 C CA    . GLU A 1 892 ? 120.192 133.539 82.664  1.00 70.54  ? 886 GLU A CA    1 
ATOM 4797 C C     . GLU A 1 892 ? 121.683 133.805 82.493  1.00 71.99  ? 886 GLU A C     1 
ATOM 4798 O O     . GLU A 1 892 ? 122.403 132.990 81.906  1.00 71.69  ? 886 GLU A O     1 
ATOM 4799 C CB    . GLU A 1 892 ? 119.385 134.307 81.618  1.00 69.35  ? 886 GLU A CB    1 
ATOM 4800 C CG    . GLU A 1 892 ? 120.095 134.486 80.287  1.00 70.62  ? 886 GLU A CG    1 
ATOM 4801 C CD    . GLU A 1 892 ? 119.174 134.996 79.199  1.00 74.45  ? 886 GLU A CD    1 
ATOM 4802 O OE1   . GLU A 1 892 ? 117.942 134.864 79.350  1.00 70.90  ? 886 GLU A OE1   1 
ATOM 4803 O OE2   . GLU A 1 892 ? 119.683 135.530 78.191  1.00 77.12  ? 886 GLU A OE2   1 
ATOM 4804 N N     . GLN A 1 893 ? 122.164 134.941 83.002  1.00 65.93  ? 887 GLN A N     1 
ATOM 4805 C CA    . GLN A 1 893 ? 123.587 135.252 82.914  1.00 67.97  ? 887 GLN A CA    1 
ATOM 4806 C C     . GLN A 1 893 ? 124.420 134.257 83.712  1.00 68.61  ? 887 GLN A C     1 
ATOM 4807 O O     . GLN A 1 893 ? 125.487 133.822 83.259  1.00 69.31  ? 887 GLN A O     1 
ATOM 4808 C CB    . GLN A 1 893 ? 123.843 136.678 83.401  1.00 63.45  ? 887 GLN A CB    1 
ATOM 4809 C CG    . GLN A 1 893 ? 123.984 137.703 82.289  1.00 60.99  ? 887 GLN A CG    1 
ATOM 4810 C CD    . GLN A 1 893 ? 124.975 137.277 81.226  1.00 66.06  ? 887 GLN A CD    1 
ATOM 4811 O OE1   . GLN A 1 893 ? 124.669 137.294 80.034  1.00 69.65  ? 887 GLN A OE1   1 
ATOM 4812 N NE2   . GLN A 1 893 ? 126.175 136.899 81.651  1.00 67.91  ? 887 GLN A NE2   1 
ATOM 4813 N N     . VAL A 1 894 ? 123.952 133.884 84.904  1.00 64.33  ? 888 VAL A N     1 
ATOM 4814 C CA    . VAL A 1 894 ? 124.680 132.907 85.708  1.00 65.09  ? 888 VAL A CA    1 
ATOM 4815 C C     . VAL A 1 894 ? 124.711 131.552 85.010  1.00 68.64  ? 888 VAL A C     1 
ATOM 4816 O O     . VAL A 1 894 ? 125.730 130.853 85.025  1.00 67.90  ? 888 VAL A O     1 
ATOM 4817 C CB    . VAL A 1 894 ? 124.072 132.810 87.118  1.00 66.95  ? 888 VAL A CB    1 
ATOM 4818 C CG1   . VAL A 1 894 ? 124.724 131.686 87.905  1.00 65.00  ? 888 VAL A CG1   1 
ATOM 4819 C CG2   . VAL A 1 894 ? 124.241 134.126 87.849  1.00 62.53  ? 888 VAL A CG2   1 
ATOM 4820 N N     . HIS A 1 895 ? 123.598 131.158 84.384  1.00 74.32  ? 889 HIS A N     1 
ATOM 4821 C CA    . HIS A 1 895 ? 123.572 129.892 83.660  1.00 71.73  ? 889 HIS A CA    1 
ATOM 4822 C C     . HIS A 1 895 ? 124.488 129.931 82.443  1.00 70.57  ? 889 HIS A C     1 
ATOM 4823 O O     . HIS A 1 895 ? 125.134 128.929 82.115  1.00 72.23  ? 889 HIS A O     1 
ATOM 4824 C CB    . HIS A 1 895 ? 122.142 129.551 83.245  1.00 72.52  ? 889 HIS A CB    1 
ATOM 4825 C CG    . HIS A 1 895 ? 121.894 128.083 83.092  1.00 75.23  ? 889 HIS A CG    1 
ATOM 4826 N ND1   . HIS A 1 895 ? 122.286 127.160 84.038  1.00 77.17  ? 889 HIS A ND1   1 
ATOM 4827 C CD2   . HIS A 1 895 ? 121.296 127.379 82.103  1.00 73.30  ? 889 HIS A CD2   1 
ATOM 4828 C CE1   . HIS A 1 895 ? 121.939 125.949 83.638  1.00 75.77  ? 889 HIS A CE1   1 
ATOM 4829 N NE2   . HIS A 1 895 ? 121.337 126.055 82.468  1.00 73.38  ? 889 HIS A NE2   1 
ATOM 4830 N N     . GLU A 1 896 ? 124.552 131.074 81.757  1.00 70.36  ? 890 GLU A N     1 
ATOM 4831 C CA    . GLU A 1 896 ? 125.490 131.218 80.649  1.00 73.97  ? 890 GLU A CA    1 
ATOM 4832 C C     . GLU A 1 896 ? 126.928 131.095 81.132  1.00 75.63  ? 890 GLU A C     1 
ATOM 4833 O O     . GLU A 1 896 ? 127.760 130.455 80.478  1.00 77.13  ? 890 GLU A O     1 
ATOM 4834 C CB    . GLU A 1 896 ? 125.274 132.557 79.947  1.00 72.91  ? 890 GLU A CB    1 
ATOM 4835 C CG    . GLU A 1 896 ? 124.343 132.493 78.749  1.00 73.60  ? 890 GLU A CG    1 
ATOM 4836 C CD    . GLU A 1 896 ? 124.139 133.845 78.097  1.00 77.40  ? 890 GLU A CD    1 
ATOM 4837 O OE1   . GLU A 1 896 ? 125.004 134.728 78.269  1.00 77.85  ? 890 GLU A OE1   1 
ATOM 4838 O OE2   . GLU A 1 896 ? 123.112 134.027 77.410  1.00 77.78  ? 890 GLU A OE2   1 
ATOM 4839 N N     . LEU A 1 897 ? 127.236 131.703 82.279  1.00 69.38  ? 891 LEU A N     1 
ATOM 4840 C CA    . LEU A 1 897 ? 128.570 131.570 82.857  1.00 68.95  ? 891 LEU A CA    1 
ATOM 4841 C C     . LEU A 1 897 ? 128.880 130.120 83.203  1.00 71.50  ? 891 LEU A C     1 
ATOM 4842 O O     . LEU A 1 897 ? 129.994 129.639 82.963  1.00 71.61  ? 891 LEU A O     1 
ATOM 4843 C CB    . LEU A 1 897 ? 128.688 132.449 84.101  1.00 68.92  ? 891 LEU A CB    1 
ATOM 4844 C CG    . LEU A 1 897 ? 130.090 132.616 84.678  1.00 67.03  ? 891 LEU A CG    1 
ATOM 4845 C CD1   . LEU A 1 897 ? 131.039 133.135 83.617  1.00 68.16  ? 891 LEU A CD1   1 
ATOM 4846 C CD2   . LEU A 1 897 ? 130.060 133.542 85.875  1.00 70.52  ? 891 LEU A CD2   1 
ATOM 4847 N N     . ARG A 1 898 ? 127.908 129.409 83.776  1.00 72.51  ? 892 ARG A N     1 
ATOM 4848 C CA    . ARG A 1 898 ? 128.110 128.006 84.118  1.00 69.78  ? 892 ARG A CA    1 
ATOM 4849 C C     . ARG A 1 898 ? 128.353 127.167 82.869  1.00 72.30  ? 892 ARG A C     1 
ATOM 4850 O O     . ARG A 1 898 ? 129.234 126.300 82.849  1.00 74.06  ? 892 ARG A O     1 
ATOM 4851 C CB    . ARG A 1 898 ? 126.901 127.482 84.893  1.00 71.17  ? 892 ARG A CB    1 
ATOM 4852 C CG    . ARG A 1 898 ? 126.755 125.972 84.886  1.00 68.19  ? 892 ARG A CG    1 
ATOM 4853 C CD    . ARG A 1 898 ? 125.379 125.560 85.379  1.00 69.65  ? 892 ARG A CD    1 
ATOM 4854 N NE    . ARG A 1 898 ? 125.278 124.120 85.582  1.00 75.24  ? 892 ARG A NE    1 
ATOM 4855 C CZ    . ARG A 1 898 ? 124.409 123.541 86.399  1.00 75.36  ? 892 ARG A CZ    1 
ATOM 4856 N NH1   . ARG A 1 898 ? 123.543 124.251 87.105  1.00 72.73  ? 892 ARG A NH1   1 
ATOM 4857 N NH2   . ARG A 1 898 ? 124.407 122.216 86.511  1.00 74.85  ? 892 ARG A NH2   1 
ATOM 4858 N N     . ASN A 1 899 ? 127.575 127.414 81.813  1.00 76.78  ? 893 ASN A N     1 
ATOM 4859 C CA    . ASN A 1 899 ? 127.765 126.683 80.566  1.00 75.23  ? 893 ASN A CA    1 
ATOM 4860 C C     . ASN A 1 899 ? 129.134 126.968 79.966  1.00 74.67  ? 893 ASN A C     1 
ATOM 4861 O O     . ASN A 1 899 ? 129.799 126.060 79.454  1.00 75.94  ? 893 ASN A O     1 
ATOM 4862 C CB    . ASN A 1 899 ? 126.659 127.038 79.573  1.00 73.07  ? 893 ASN A CB    1 
ATOM 4863 C CG    . ASN A 1 899 ? 125.325 126.419 79.941  1.00 77.71  ? 893 ASN A CG    1 
ATOM 4864 O OD1   . ASN A 1 899 ? 125.222 125.671 80.913  1.00 80.90  ? 893 ASN A OD1   1 
ATOM 4865 N ND2   . ASN A 1 899 ? 124.295 126.729 79.164  1.00 73.32  ? 893 ASN A ND2   1 
ATOM 4866 N N     . GLN A 1 900 ? 129.572 128.228 80.016  1.00 70.92  ? 894 GLN A N     1 
ATOM 4867 C CA    . GLN A 1 900 ? 130.884 128.577 79.483  1.00 72.64  ? 894 GLN A CA    1 
ATOM 4868 C C     . GLN A 1 900 ? 132.003 127.933 80.292  1.00 74.03  ? 894 GLN A C     1 
ATOM 4869 O O     . GLN A 1 900 ? 133.015 127.504 79.727  1.00 72.44  ? 894 GLN A O     1 
ATOM 4870 C CB    . GLN A 1 900 ? 131.050 130.095 79.455  1.00 70.54  ? 894 GLN A CB    1 
ATOM 4871 C CG    . GLN A 1 900 ? 132.240 130.573 78.644  1.00 73.21  ? 894 GLN A CG    1 
ATOM 4872 C CD    . GLN A 1 900 ? 132.564 132.030 78.896  1.00 78.36  ? 894 GLN A CD    1 
ATOM 4873 O OE1   . GLN A 1 900 ? 131.693 132.815 79.268  1.00 82.56  ? 894 GLN A OE1   1 
ATOM 4874 N NE2   . GLN A 1 900 ? 133.823 132.400 78.692  1.00 77.03  ? 894 GLN A NE2   1 
ATOM 4875 N N     . VAL A 1 901 ? 131.843 127.859 81.614  1.00 77.94  ? 895 VAL A N     1 
ATOM 4876 C CA    . VAL A 1 901 ? 132.913 127.320 82.446  1.00 76.28  ? 895 VAL A CA    1 
ATOM 4877 C C     . VAL A 1 901 ? 132.947 125.796 82.387  1.00 74.69  ? 895 VAL A C     1 
ATOM 4878 O O     . VAL A 1 901 ? 134.009 125.191 82.573  1.00 74.47  ? 895 VAL A O     1 
ATOM 4879 C CB    . VAL A 1 901 ? 132.779 127.830 83.892  1.00 70.61  ? 895 VAL A CB    1 
ATOM 4880 C CG1   . VAL A 1 901 ? 131.735 127.038 84.658  1.00 69.98  ? 895 VAL A CG1   1 
ATOM 4881 C CG2   . VAL A 1 901 ? 134.117 127.767 84.597  1.00 69.73  ? 895 VAL A CG2   1 
ATOM 4882 N N     . LEU A 1 902 ? 131.807 125.150 82.130  1.00 73.98  ? 896 LEU A N     1 
ATOM 4883 C CA    . LEU A 1 902 ? 131.803 123.696 82.022  1.00 71.89  ? 896 LEU A CA    1 
ATOM 4884 C C     . LEU A 1 902 ? 132.489 123.237 80.741  1.00 77.21  ? 896 LEU A C     1 
ATOM 4885 O O     . LEU A 1 902 ? 133.161 122.200 80.727  1.00 74.47  ? 896 LEU A O     1 
ATOM 4886 C CB    . LEU A 1 902 ? 130.373 123.169 82.088  1.00 73.60  ? 896 LEU A CB    1 
ATOM 4887 C CG    . LEU A 1 902 ? 129.979 122.533 83.421  1.00 75.63  ? 896 LEU A CG    1 
ATOM 4888 C CD1   . LEU A 1 902 ? 128.467 122.441 83.556  1.00 76.23  ? 896 LEU A CD1   1 
ATOM 4889 C CD2   . LEU A 1 902 ? 130.621 121.162 83.563  1.00 76.02  ? 896 LEU A CD2   1 
ATOM 4890 N N     . ALA A 1 903 ? 132.329 123.996 79.655  1.00 83.86  ? 897 ALA A N     1 
ATOM 4891 C CA    . ALA A 1 903 ? 132.976 123.634 78.399  1.00 81.56  ? 897 ALA A CA    1 
ATOM 4892 C C     . ALA A 1 903 ? 134.476 123.895 78.452  1.00 79.25  ? 897 ALA A C     1 
ATOM 4893 O O     . ALA A 1 903 ? 135.266 123.133 77.883  1.00 82.21  ? 897 ALA A O     1 
ATOM 4894 C CB    . ALA A 1 903 ? 132.339 124.401 77.241  1.00 77.90  ? 897 ALA A CB    1 
ATOM 4895 N N     . LEU A 1 904 ? 134.889 124.971 79.127  1.00 77.75  ? 898 LEU A N     1 
ATOM 4896 C CA    . LEU A 1 904 ? 136.303 125.324 79.174  1.00 80.62  ? 898 LEU A CA    1 
ATOM 4897 C C     . LEU A 1 904 ? 137.121 124.264 79.902  1.00 80.95  ? 898 LEU A C     1 
ATOM 4898 O O     . LEU A 1 904 ? 138.221 123.907 79.462  1.00 78.91  ? 898 LEU A O     1 
ATOM 4899 C CB    . LEU A 1 904 ? 136.484 126.687 79.840  1.00 80.61  ? 898 LEU A CB    1 
ATOM 4900 C CG    . LEU A 1 904 ? 137.862 127.338 79.695  1.00 79.34  ? 898 LEU A CG    1 
ATOM 4901 C CD1   . LEU A 1 904 ? 138.412 127.154 78.289  1.00 80.17  ? 898 LEU A CD1   1 
ATOM 4902 C CD2   . LEU A 1 904 ? 137.800 128.811 80.062  1.00 78.59  ? 898 LEU A CD2   1 
ATOM 4903 N N     . GLY A 1 905 ? 136.607 123.754 81.018  1.00 84.73  ? 899 GLY A N     1 
ATOM 4904 C CA    . GLY A 1 905 ? 137.363 122.818 81.825  1.00 86.27  ? 899 GLY A CA    1 
ATOM 4905 C C     . GLY A 1 905 ? 138.287 123.522 82.796  1.00 87.74  ? 899 GLY A C     1 
ATOM 4906 O O     . GLY A 1 905 ? 138.999 124.456 82.415  1.00 87.69  ? 899 GLY A O     1 
ATOM 4907 N N     . ASN A 1 906 ? 138.290 123.078 84.055  1.00 84.15  ? 900 ASN A N     1 
ATOM 4908 C CA    . ASN A 1 906 ? 139.063 123.757 85.090  1.00 84.83  ? 900 ASN A CA    1 
ATOM 4909 C C     . ASN A 1 906 ? 140.562 123.718 84.826  1.00 83.78  ? 900 ASN A C     1 
ATOM 4910 O O     . ASN A 1 906 ? 141.297 124.538 85.389  1.00 80.71  ? 900 ASN A O     1 
ATOM 4911 C CB    . ASN A 1 906 ? 138.761 123.139 86.457  1.00 82.64  ? 900 ASN A CB    1 
ATOM 4912 C CG    . ASN A 1 906 ? 138.730 121.625 86.417  1.00 85.31  ? 900 ASN A CG    1 
ATOM 4913 O OD1   . ASN A 1 906 ? 137.703 121.022 86.110  1.00 86.98  ? 900 ASN A OD1   1 
ATOM 4914 N ND2   . ASN A 1 906 ? 139.862 121.003 86.724  1.00 85.11  ? 900 ASN A ND2   1 
ATOM 4915 N N     . ALA A 1 907 ? 141.034 122.789 83.992  1.00 85.48  ? 901 ALA A N     1 
ATOM 4916 C CA    . ALA A 1 907 ? 142.464 122.702 83.714  1.00 84.93  ? 901 ALA A CA    1 
ATOM 4917 C C     . ALA A 1 907 ? 142.978 123.970 83.043  1.00 84.26  ? 901 ALA A C     1 
ATOM 4918 O O     . ALA A 1 907 ? 144.065 124.458 83.371  1.00 83.99  ? 901 ALA A O     1 
ATOM 4919 C CB    . ALA A 1 907 ? 142.756 121.478 82.846  1.00 83.10  ? 901 ALA A CB    1 
ATOM 4920 N N     . LYS A 1 908 ? 142.209 124.518 82.107  1.00 85.99  ? 902 LYS A N     1 
ATOM 4921 C CA    . LYS A 1 908 ? 142.590 125.737 81.405  1.00 88.39  ? 902 LYS A CA    1 
ATOM 4922 C C     . LYS A 1 908 ? 142.184 127.001 82.150  1.00 91.01  ? 902 LYS A C     1 
ATOM 4923 O O     . LYS A 1 908 ? 142.413 128.104 81.641  1.00 89.95  ? 902 LYS A O     1 
ATOM 4924 C CB    . LYS A 1 908 ? 141.980 125.747 80.000  1.00 87.20  ? 902 LYS A CB    1 
ATOM 4925 C CG    . LYS A 1 908 ? 142.207 124.463 79.220  1.00 89.53  ? 902 LYS A CG    1 
ATOM 4926 C CD    . LYS A 1 908 ? 143.273 124.651 78.152  1.00 89.92  ? 902 LYS A CD    1 
ATOM 4927 C CE    . LYS A 1 908 ? 143.393 123.422 77.268  1.00 88.30  ? 902 LYS A CE    1 
ATOM 4928 N NZ    . LYS A 1 908 ? 143.943 122.256 78.011  1.00 88.51  ? 902 LYS A NZ    1 
ATOM 4929 N N     . ILE A 1 909 ? 141.590 126.870 83.332  1.00 76.61  ? 903 ILE A N     1 
ATOM 4930 C CA    . ILE A 1 909 ? 141.153 128.009 84.133  1.00 66.97  ? 903 ILE A CA    1 
ATOM 4931 C C     . ILE A 1 909 ? 142.192 128.231 85.230  1.00 67.57  ? 903 ILE A C     1 
ATOM 4932 O O     . ILE A 1 909 ? 142.348 127.362 86.104  1.00 69.20  ? 903 ILE A O     1 
ATOM 4933 C CB    . ILE A 1 909 ? 139.756 127.778 84.722  1.00 67.22  ? 903 ILE A CB    1 
ATOM 4934 C CG1   . ILE A 1 909 ? 138.694 127.972 83.640  1.00 71.48  ? 903 ILE A CG1   1 
ATOM 4935 C CG2   . ILE A 1 909 ? 139.500 128.715 85.886  1.00 70.82  ? 903 ILE A CG2   1 
ATOM 4936 C CD1   . ILE A 1 909 ? 137.518 127.040 83.772  1.00 72.00  ? 903 ILE A CD1   1 
ATOM 4937 N N     . PRO A 1 910 ? 142.927 129.340 85.217  1.00 64.05  ? 904 PRO A N     1 
ATOM 4938 C CA    . PRO A 1 910 ? 143.941 129.567 86.251  1.00 63.17  ? 904 PRO A CA    1 
ATOM 4939 C C     . PRO A 1 910 ? 143.317 129.756 87.624  1.00 62.79  ? 904 PRO A C     1 
ATOM 4940 O O     . PRO A 1 910 ? 142.188 130.227 87.765  1.00 66.72  ? 904 PRO A O     1 
ATOM 4941 C CB    . PRO A 1 910 ? 144.645 130.848 85.783  1.00 59.04  ? 904 PRO A CB    1 
ATOM 4942 C CG    . PRO A 1 910 ? 144.329 130.948 84.322  1.00 58.85  ? 904 PRO A CG    1 
ATOM 4943 C CD    . PRO A 1 910 ? 142.952 130.385 84.183  1.00 62.17  ? 904 PRO A CD    1 
ATOM 4944 N N     . GLU A 1 911 ? 144.079 129.378 88.648  1.00 59.42  ? 905 GLU A N     1 
ATOM 4945 C CA    . GLU A 1 911 ? 143.664 129.513 90.038  1.00 61.15  ? 905 GLU A CA    1 
ATOM 4946 C C     . GLU A 1 911 ? 144.529 130.569 90.711  1.00 63.98  ? 905 GLU A C     1 
ATOM 4947 O O     . GLU A 1 911 ? 145.761 130.488 90.665  1.00 63.84  ? 905 GLU A O     1 
ATOM 4948 C CB    . GLU A 1 911 ? 143.774 128.179 90.775  1.00 61.01  ? 905 GLU A CB    1 
ATOM 4949 C CG    . GLU A 1 911 ? 143.647 128.297 92.283  1.00 63.19  ? 905 GLU A CG    1 
ATOM 4950 C CD    . GLU A 1 911 ? 142.919 127.122 92.899  1.00 64.51  ? 905 GLU A CD    1 
ATOM 4951 O OE1   . GLU A 1 911 ? 142.870 126.051 92.259  1.00 66.10  ? 905 GLU A OE1   1 
ATOM 4952 O OE2   . GLU A 1 911 ? 142.397 127.268 94.023  1.00 63.60  ? 905 GLU A OE2   1 
ATOM 4953 N N     . ILE A 1 912 ? 143.884 131.551 91.338  1.00 63.36  ? 906 ILE A N     1 
ATOM 4954 C CA    . ILE A 1 912 ? 144.616 132.638 91.976  1.00 64.48  ? 906 ILE A CA    1 
ATOM 4955 C C     . ILE A 1 912 ? 145.090 132.205 93.361  1.00 64.32  ? 906 ILE A C     1 
ATOM 4956 O O     . ILE A 1 912 ? 144.682 131.171 93.896  1.00 68.19  ? 906 ILE A O     1 
ATOM 4957 C CB    . ILE A 1 912 ? 143.762 133.916 92.047  1.00 63.44  ? 906 ILE A CB    1 
ATOM 4958 C CG1   . ILE A 1 912 ? 142.934 133.945 93.329  1.00 62.01  ? 906 ILE A CG1   1 
ATOM 4959 C CG2   . ILE A 1 912 ? 142.847 134.011 90.838  1.00 55.79  ? 906 ILE A CG2   1 
ATOM 4960 C CD1   . ILE A 1 912 ? 142.151 135.220 93.492  1.00 62.35  ? 906 ILE A CD1   1 
ATOM 4961 N N     . ARG A 1 913 ? 145.979 133.013 93.939  1.00 69.39  ? 907 ARG A N     1 
ATOM 4962 C CA    . ARG A 1 913 ? 146.548 132.708 95.246  1.00 69.66  ? 907 ARG A CA    1 
ATOM 4963 C C     . ARG A 1 913 ? 145.461 132.615 96.308  1.00 69.12  ? 907 ARG A C     1 
ATOM 4964 O O     . ARG A 1 913 ? 144.463 133.340 96.270  1.00 70.06  ? 907 ARG A O     1 
ATOM 4965 C CB    . ARG A 1 913 ? 147.569 133.781 95.637  1.00 73.75  ? 907 ARG A CB    1 
ATOM 4966 C CG    . ARG A 1 913 ? 148.365 133.478 96.902  1.00 71.03  ? 907 ARG A CG    1 
ATOM 4967 C CD    . ARG A 1 913 ? 147.779 134.177 98.123  1.00 68.42  ? 907 ARG A CD    1 
ATOM 4968 N NE    . ARG A 1 913 ? 148.181 135.576 98.209  1.00 69.71  ? 907 ARG A NE    1 
ATOM 4969 C CZ    . ARG A 1 913 ? 149.234 136.012 98.890  1.00 73.44  ? 907 ARG A CZ    1 
ATOM 4970 N NH1   . ARG A 1 913 ? 150.016 135.182 99.559  1.00 74.66  ? 907 ARG A NH1   1 
ATOM 4971 N NH2   . ARG A 1 913 ? 149.504 137.314 98.902  1.00 71.96  ? 907 ARG A NH2   1 
ATOM 4972 N N     . THR A 1 914 ? 145.658 131.709 97.260  1.00 66.32  ? 908 THR A N     1 
ATOM 4973 C CA    . THR A 1 914 ? 144.739 131.551 98.380  1.00 69.70  ? 908 THR A CA    1 
ATOM 4974 C C     . THR A 1 914 ? 145.443 130.900 99.568  1.00 68.38  ? 908 THR A C     1 
ATOM 4975 O O     . THR A 1 914 ? 144.810 130.242 100.393 1.00 69.19  ? 908 THR A O     1 
ATOM 4976 C CB    . THR A 1 914 ? 143.517 130.707 97.992  1.00 73.18  ? 908 THR A CB    1 
ATOM 4977 O OG1   . THR A 1 914 ? 142.827 130.294 99.177  1.00 74.04  ? 908 THR A OG1   1 
ATOM 4978 C CG2   . THR A 1 914 ? 143.950 129.480 97.207  1.00 70.94  ? 908 THR A CG2   1 
ATOM 4979 P P     . G   B 2 1   ? 139.635 115.056 138.915 1.00 80.37  ? -36 G   B P     1 
ATOM 4980 O OP1   . G   B 2 1   ? 140.021 116.333 139.564 1.00 52.83  ? -36 G   B OP1   1 
ATOM 4981 O OP2   . G   B 2 1   ? 140.114 113.769 139.480 1.00 62.60  ? -36 G   B OP2   1 
ATOM 4982 O "O5'" . G   B 2 1   ? 138.046 115.011 138.860 1.00 60.19  ? -36 G   B "O5'" 1 
ATOM 4983 C "C5'" . G   B 2 1   ? 137.266 115.521 139.931 1.00 49.60  ? -36 G   B "C5'" 1 
ATOM 4984 C "C4'" . G   B 2 1   ? 136.380 116.649 139.472 1.00 40.69  ? -36 G   B "C4'" 1 
ATOM 4985 O "O4'" . G   B 2 1   ? 137.175 117.834 139.241 1.00 44.02  ? -36 G   B "O4'" 1 
ATOM 4986 C "C3'" . G   B 2 1   ? 135.653 116.422 138.157 1.00 43.57  ? -36 G   B "C3'" 1 
ATOM 4987 O "O3'" . G   B 2 1   ? 134.465 115.672 138.331 1.00 45.43  ? -36 G   B "O3'" 1 
ATOM 4988 C "C2'" . G   B 2 1   ? 135.404 117.839 137.651 1.00 48.94  ? -36 G   B "C2'" 1 
ATOM 4989 O "O2'" . G   B 2 1   ? 134.255 118.395 138.272 1.00 53.70  ? -36 G   B "O2'" 1 
ATOM 4990 C "C1'" . G   B 2 1   ? 136.631 118.583 138.177 1.00 39.16  ? -36 G   B "C1'" 1 
ATOM 4991 N N9    . G   B 2 1   ? 137.685 118.805 137.169 1.00 39.18  ? -36 G   B N9    1 
ATOM 4992 C C8    . G   B 2 1   ? 138.945 118.262 137.209 1.00 40.65  ? -36 G   B C8    1 
ATOM 4993 N N7    . G   B 2 1   ? 139.706 118.641 136.226 1.00 41.07  ? -36 G   B N7    1 
ATOM 4994 C C5    . G   B 2 1   ? 138.907 119.502 135.493 1.00 40.66  ? -36 G   B C5    1 
ATOM 4995 C C6    . G   B 2 1   ? 139.199 120.221 134.312 1.00 43.59  ? -36 G   B C6    1 
ATOM 4996 O O6    . G   B 2 1   ? 140.243 120.253 133.650 1.00 50.17  ? -36 G   B O6    1 
ATOM 4997 N N1    . G   B 2 1   ? 138.116 120.977 133.899 1.00 44.44  ? -36 G   B N1    1 
ATOM 4998 C C2    . G   B 2 1   ? 136.901 121.042 134.531 1.00 47.22  ? -36 G   B C2    1 
ATOM 4999 N N2    . G   B 2 1   ? 135.990 121.838 133.954 1.00 45.00  ? -36 G   B N2    1 
ATOM 5000 N N3    . G   B 2 1   ? 136.614 120.373 135.637 1.00 45.55  ? -36 G   B N3    1 
ATOM 5001 C C4    . G   B 2 1   ? 137.658 119.628 136.064 1.00 42.07  ? -36 G   B C4    1 
ATOM 5002 P P     . U   B 2 2   ? 133.985 114.630 137.211 1.00 66.03  ? -35 U   B P     1 
ATOM 5003 O OP1   . U   B 2 2   ? 132.856 113.850 137.773 1.00 56.40  ? -35 U   B OP1   1 
ATOM 5004 O OP2   . U   B 2 2   ? 135.183 113.931 136.682 1.00 57.52  ? -35 U   B OP2   1 
ATOM 5005 O "O5'" . U   B 2 2   ? 133.402 115.554 136.057 1.00 53.04  ? -35 U   B "O5'" 1 
ATOM 5006 C "C5'" . U   B 2 2   ? 132.334 116.453 136.315 1.00 45.32  ? -35 U   B "C5'" 1 
ATOM 5007 C "C4'" . U   B 2 2   ? 132.158 117.425 135.178 1.00 47.63  ? -35 U   B "C4'" 1 
ATOM 5008 O "O4'" . U   B 2 2   ? 133.325 118.280 135.079 1.00 51.39  ? -35 U   B "O4'" 1 
ATOM 5009 C "C3'" . U   B 2 2   ? 132.037 116.804 133.799 1.00 47.57  ? -35 U   B "C3'" 1 
ATOM 5010 O "O3'" . U   B 2 2   ? 130.730 116.338 133.523 1.00 49.91  ? -35 U   B "O3'" 1 
ATOM 5011 C "C2'" . U   B 2 2   ? 132.495 117.933 132.885 1.00 47.65  ? -35 U   B "C2'" 1 
ATOM 5012 O "O2'" . U   B 2 2   ? 131.459 118.888 132.713 1.00 51.74  ? -35 U   B "O2'" 1 
ATOM 5013 C "C1'" . U   B 2 2   ? 133.595 118.573 133.727 1.00 40.10  ? -35 U   B "C1'" 1 
ATOM 5014 N N1    . U   B 2 2   ? 134.940 118.052 133.399 1.00 36.00  ? -35 U   B N1    1 
ATOM 5015 C C2    . U   B 2 2   ? 135.591 118.594 132.316 1.00 43.17  ? -35 U   B C2    1 
ATOM 5016 O O2    . U   B 2 2   ? 135.098 119.462 131.620 1.00 41.37  ? -35 U   B O2    1 
ATOM 5017 N N3    . U   B 2 2   ? 136.839 118.077 132.074 1.00 47.85  ? -35 U   B N3    1 
ATOM 5018 C C4    . U   B 2 2   ? 137.487 117.099 132.799 1.00 49.80  ? -35 U   B C4    1 
ATOM 5019 O O4    . U   B 2 2   ? 138.611 116.736 132.453 1.00 51.84  ? -35 U   B O4    1 
ATOM 5020 C C5    . U   B 2 2   ? 136.748 116.591 133.908 1.00 48.90  ? -35 U   B C5    1 
ATOM 5021 C C6    . U   B 2 2   ? 135.532 117.077 134.165 1.00 46.60  ? -35 U   B C6    1 
ATOM 5022 P P     . G   B 2 3   ? 130.515 114.894 132.857 1.00 44.89  ? -34 G   B P     1 
ATOM 5023 O OP1   . G   B 2 3   ? 129.166 114.412 133.238 1.00 54.85  ? -34 G   B OP1   1 
ATOM 5024 O OP2   . G   B 2 3   ? 131.707 114.064 133.155 1.00 48.90  ? -34 G   B OP2   1 
ATOM 5025 O "O5'" . G   B 2 3   ? 130.509 115.200 131.296 1.00 62.71  ? -34 G   B "O5'" 1 
ATOM 5026 C "C5'" . G   B 2 3   ? 131.442 114.579 130.426 1.00 58.62  ? -34 G   B "C5'" 1 
ATOM 5027 C "C4'" . G   B 2 3   ? 131.763 115.463 129.250 1.00 49.51  ? -34 G   B "C4'" 1 
ATOM 5028 O "O4'" . G   B 2 3   ? 132.724 116.473 129.645 1.00 43.06  ? -34 G   B "O4'" 1 
ATOM 5029 C "C3'" . G   B 2 3   ? 132.414 114.774 128.061 1.00 51.36  ? -34 G   B "C3'" 1 
ATOM 5030 O "O3'" . G   B 2 3   ? 131.461 114.142 127.222 1.00 51.07  ? -34 G   B "O3'" 1 
ATOM 5031 C "C2'" . G   B 2 3   ? 133.161 115.913 127.379 1.00 56.70  ? -34 G   B "C2'" 1 
ATOM 5032 O "O2'" . G   B 2 3   ? 132.277 116.690 126.586 1.00 64.30  ? -34 G   B "O2'" 1 
ATOM 5033 C "C1'" . G   B 2 3   ? 133.595 116.759 128.575 1.00 41.12  ? -34 G   B "C1'" 1 
ATOM 5034 N N9    . G   B 2 3   ? 134.976 116.481 129.006 1.00 43.83  ? -34 G   B N9    1 
ATOM 5035 C C8    . G   B 2 3   ? 135.356 115.816 130.142 1.00 54.95  ? -34 G   B C8    1 
ATOM 5036 N N7    . G   B 2 3   ? 136.648 115.730 130.279 1.00 48.17  ? -34 G   B N7    1 
ATOM 5037 C C5    . G   B 2 3   ? 137.154 116.387 129.172 1.00 46.38  ? -34 G   B C5    1 
ATOM 5038 C C6    . G   B 2 3   ? 138.496 116.616 128.780 1.00 49.09  ? -34 G   B C6    1 
ATOM 5039 O O6    . G   B 2 3   ? 139.537 116.274 129.356 1.00 54.73  ? -34 G   B O6    1 
ATOM 5040 N N1    . G   B 2 3   ? 138.561 117.320 127.587 1.00 48.19  ? -34 G   B N1    1 
ATOM 5041 C C2    . G   B 2 3   ? 137.480 117.749 126.860 1.00 50.42  ? -34 G   B C2    1 
ATOM 5042 N N2    . G   B 2 3   ? 137.743 118.416 125.731 1.00 57.15  ? -34 G   B N2    1 
ATOM 5043 N N3    . G   B 2 3   ? 136.224 117.543 127.217 1.00 49.86  ? -34 G   B N3    1 
ATOM 5044 C C4    . G   B 2 3   ? 136.136 116.860 128.376 1.00 47.82  ? -34 G   B C4    1 
ATOM 5045 P P     . C   B 2 4   ? 131.828 112.792 126.436 1.00 30.53  ? -33 C   B P     1 
ATOM 5046 O OP1   . C   B 2 4   ? 130.586 112.254 125.840 1.00 24.47  ? -33 C   B OP1   1 
ATOM 5047 O OP2   . C   B 2 4   ? 132.641 111.939 127.333 1.00 42.41  ? -33 C   B OP2   1 
ATOM 5048 O "O5'" . C   B 2 4   ? 132.765 113.284 125.250 1.00 40.64  ? -33 C   B "O5'" 1 
ATOM 5049 C "C5'" . C   B 2 4   ? 132.317 114.239 124.302 1.00 25.66  ? -33 C   B "C5'" 1 
ATOM 5050 C "C4'" . C   B 2 4   ? 133.474 114.793 123.513 1.00 17.95  ? -33 C   B "C4'" 1 
ATOM 5051 O "O4'" . C   B 2 4   ? 134.380 115.480 124.410 1.00 6.43   ? -33 C   B "O4'" 1 
ATOM 5052 C "C3'" . C   B 2 4   ? 134.345 113.761 122.815 1.00 31.69  ? -33 C   B "C3'" 1 
ATOM 5053 O "O3'" . C   B 2 4   ? 133.813 113.358 121.566 1.00 35.47  ? -33 C   B "O3'" 1 
ATOM 5054 C "C2'" . C   B 2 4   ? 135.691 114.464 122.709 1.00 37.63  ? -33 C   B "C2'" 1 
ATOM 5055 O "O2'" . C   B 2 4   ? 135.705 115.362 121.609 1.00 37.14  ? -33 C   B "O2'" 1 
ATOM 5056 C "C1'" . C   B 2 4   ? 135.713 115.285 123.997 1.00 24.20  ? -33 C   B "C1'" 1 
ATOM 5057 N N1    . C   B 2 4   ? 136.453 114.624 125.097 1.00 24.51  ? -33 C   B N1    1 
ATOM 5058 C C2    . C   B 2 4   ? 137.832 114.804 125.186 1.00 34.68  ? -33 C   B C2    1 
ATOM 5059 O O2    . C   B 2 4   ? 138.410 115.487 124.335 1.00 39.66  ? -33 C   B O2    1 
ATOM 5060 N N3    . C   B 2 4   ? 138.522 114.223 126.189 1.00 33.01  ? -33 C   B N3    1 
ATOM 5061 C C4    . C   B 2 4   ? 137.884 113.488 127.096 1.00 36.26  ? -33 C   B C4    1 
ATOM 5062 N N4    . C   B 2 4   ? 138.611 112.934 128.069 1.00 38.65  ? -33 C   B N4    1 
ATOM 5063 C C5    . C   B 2 4   ? 136.476 113.291 127.041 1.00 27.04  ? -33 C   B C5    1 
ATOM 5064 C C6    . C   B 2 4   ? 135.809 113.875 126.038 1.00 18.95  ? -33 C   B C6    1 
ATOM 5065 P P     . U   B 2 5   ? 134.217 111.930 120.941 1.00 39.41  ? -32 U   B P     1 
ATOM 5066 O OP1   . U   B 2 5   ? 135.685 111.920 120.714 1.00 16.70  ? -32 U   B OP1   1 
ATOM 5067 O OP2   . U   B 2 5   ? 133.319 111.666 119.797 1.00 35.50  ? -32 U   B OP2   1 
ATOM 5068 O "O5'" . U   B 2 5   ? 133.857 110.905 122.110 1.00 30.24  ? -32 U   B "O5'" 1 
ATOM 5069 C "C5'" . U   B 2 5   ? 133.778 109.486 121.864 1.00 12.13  ? -32 U   B "C5'" 1 
ATOM 5070 C "C4'" . U   B 2 5   ? 134.075 108.701 123.124 1.00 20.19  ? -32 U   B "C4'" 1 
ATOM 5071 O "O4'" . U   B 2 5   ? 135.505 108.746 123.400 1.00 34.92  ? -32 U   B "O4'" 1 
ATOM 5072 C "C3'" . U   B 2 5   ? 133.388 109.184 124.399 1.00 20.61  ? -32 U   B "C3'" 1 
ATOM 5073 O "O3'" . U   B 2 5   ? 133.049 108.086 125.244 1.00 30.38  ? -32 U   B "O3'" 1 
ATOM 5074 C "C2'" . U   B 2 5   ? 134.482 109.996 125.080 1.00 21.47  ? -32 U   B "C2'" 1 
ATOM 5075 O "O2'" . U   B 2 5   ? 134.336 110.095 126.481 1.00 25.72  ? -32 U   B "O2'" 1 
ATOM 5076 C "C1'" . U   B 2 5   ? 135.709 109.158 124.736 1.00 30.02  ? -32 U   B "C1'" 1 
ATOM 5077 N N1    . U   B 2 5   ? 136.990 109.874 124.818 1.00 17.45  ? -32 U   B N1    1 
ATOM 5078 C C2    . U   B 2 5   ? 137.192 110.956 123.984 1.00 22.53  ? -32 U   B C2    1 
ATOM 5079 O O2    . U   B 2 5   ? 136.356 111.346 123.190 1.00 34.15  ? -32 U   B O2    1 
ATOM 5080 N N3    . U   B 2 5   ? 138.414 111.565 124.117 1.00 6.36   ? -32 U   B N3    1 
ATOM 5081 C C4    . U   B 2 5   ? 139.434 111.214 124.975 1.00 24.44  ? -32 U   B C4    1 
ATOM 5082 O O4    . U   B 2 5   ? 140.479 111.863 124.971 1.00 40.76  ? -32 U   B O4    1 
ATOM 5083 C C5    . U   B 2 5   ? 139.149 110.084 125.804 1.00 26.22  ? -32 U   B C5    1 
ATOM 5084 C C6    . U   B 2 5   ? 137.965 109.470 125.702 1.00 16.93  ? -32 U   B C6    1 
ATOM 5085 P P     . G   B 2 6   ? 131.618 107.353 125.124 1.00 43.33  ? -31 G   B P     1 
ATOM 5086 O OP1   . G   B 2 6   ? 130.633 108.311 124.566 1.00 51.85  ? -31 G   B OP1   1 
ATOM 5087 O OP2   . G   B 2 6   ? 131.333 106.673 126.410 1.00 46.41  ? -31 G   B OP2   1 
ATOM 5088 O "O5'" . G   B 2 6   ? 131.879 106.214 124.044 1.00 38.40  ? -31 G   B "O5'" 1 
ATOM 5089 C "C5'" . G   B 2 6   ? 132.583 105.032 124.390 1.00 41.07  ? -31 G   B "C5'" 1 
ATOM 5090 C "C4'" . G   B 2 6   ? 133.831 104.869 123.561 1.00 44.44  ? -31 G   B "C4'" 1 
ATOM 5091 O "O4'" . G   B 2 6   ? 134.876 105.741 124.079 1.00 49.60  ? -31 G   B "O4'" 1 
ATOM 5092 C "C3'" . G   B 2 6   ? 134.465 103.487 123.580 1.00 44.13  ? -31 G   B "C3'" 1 
ATOM 5093 O "O3'" . G   B 2 6   ? 133.847 102.566 122.698 1.00 56.15  ? -31 G   B "O3'" 1 
ATOM 5094 C "C2'" . G   B 2 6   ? 135.910 103.793 123.240 1.00 41.25  ? -31 G   B "C2'" 1 
ATOM 5095 O "O2'" . G   B 2 6   ? 136.041 104.101 121.862 1.00 33.33  ? -31 G   B "O2'" 1 
ATOM 5096 C "C1'" . G   B 2 6   ? 136.120 105.075 124.042 1.00 48.54  ? -31 G   B "C1'" 1 
ATOM 5097 N N9    . G   B 2 6   ? 136.482 104.763 125.436 1.00 42.14  ? -31 G   B N9    1 
ATOM 5098 C C8    . G   B 2 6   ? 135.885 105.290 126.553 1.00 39.11  ? -31 G   B C8    1 
ATOM 5099 N N7    . G   B 2 6   ? 136.374 104.825 127.666 1.00 41.97  ? -31 G   B N7    1 
ATOM 5100 C C5    . G   B 2 6   ? 137.353 103.930 127.261 1.00 47.24  ? -31 G   B C5    1 
ATOM 5101 C C6    . G   B 2 6   ? 138.225 103.118 128.028 1.00 57.29  ? -31 G   B C6    1 
ATOM 5102 O O6    . G   B 2 6   ? 138.307 103.023 129.259 1.00 65.90  ? -31 G   B O6    1 
ATOM 5103 N N1    . G   B 2 6   ? 139.059 102.355 127.221 1.00 57.44  ? -31 G   B N1    1 
ATOM 5104 C C2    . G   B 2 6   ? 139.064 102.371 125.850 1.00 53.40  ? -31 G   B C2    1 
ATOM 5105 N N2    . G   B 2 6   ? 139.942 101.565 125.241 1.00 56.73  ? -31 G   B N2    1 
ATOM 5106 N N3    . G   B 2 6   ? 138.259 103.124 125.128 1.00 47.17  ? -31 G   B N3    1 
ATOM 5107 C C4    . G   B 2 6   ? 137.433 103.876 125.886 1.00 42.79  ? -31 G   B C4    1 
ATOM 5108 P P     . C   B 2 7   ? 133.333 101.144 123.246 1.00 57.55  ? -30 C   B P     1 
ATOM 5109 O OP1   . C   B 2 7   ? 132.493 100.512 122.202 1.00 60.88  ? -30 C   B OP1   1 
ATOM 5110 O OP2   . C   B 2 7   ? 132.774 101.355 124.602 1.00 61.23  ? -30 C   B OP2   1 
ATOM 5111 O "O5'" . C   B 2 7   ? 134.662 100.281 123.401 1.00 59.33  ? -30 C   B "O5'" 1 
ATOM 5112 C "C5'" . C   B 2 7   ? 135.413 99.873  122.268 1.00 61.57  ? -30 C   B "C5'" 1 
ATOM 5113 C "C4'" . C   B 2 7   ? 136.560 98.977  122.663 1.00 60.76  ? -30 C   B "C4'" 1 
ATOM 5114 O "O4'" . C   B 2 7   ? 137.431 99.683  123.584 1.00 60.68  ? -30 C   B "O4'" 1 
ATOM 5115 C "C3'" . C   B 2 7   ? 136.177 97.705  123.407 1.00 65.99  ? -30 C   B "C3'" 1 
ATOM 5116 O "O3'" . C   B 2 7   ? 135.806 96.651  122.532 1.00 67.49  ? -30 C   B "O3'" 1 
ATOM 5117 C "C2'" . C   B 2 7   ? 137.425 97.398  124.222 1.00 66.75  ? -30 C   B "C2'" 1 
ATOM 5118 O "O2'" . C   B 2 7   ? 138.409 96.769  123.414 1.00 68.18  ? -30 C   B "O2'" 1 
ATOM 5119 C "C1'" . C   B 2 7   ? 137.916 98.801  124.571 1.00 62.29  ? -30 C   B "C1'" 1 
ATOM 5120 N N1    . C   B 2 7   ? 137.434 99.272  125.890 1.00 60.30  ? -30 C   B N1    1 
ATOM 5121 C C2    . C   B 2 7   ? 137.885 98.692  127.083 1.00 67.52  ? -30 C   B C2    1 
ATOM 5122 O O2    . C   B 2 7   ? 138.687 97.748  127.033 1.00 73.94  ? -30 C   B O2    1 
ATOM 5123 N N3    . C   B 2 7   ? 137.422 99.173  128.262 1.00 67.12  ? -30 C   B N3    1 
ATOM 5124 C C4    . C   B 2 7   ? 136.560 100.189 128.281 1.00 60.87  ? -30 C   B C4    1 
ATOM 5125 N N4    . C   B 2 7   ? 136.123 100.641 129.458 1.00 62.01  ? -30 C   B N4    1 
ATOM 5126 C C5    . C   B 2 7   ? 136.095 100.799 127.087 1.00 58.04  ? -30 C   B C5    1 
ATOM 5127 C C6    . C   B 2 7   ? 136.557 100.316 125.934 1.00 61.93  ? -30 C   B C6    1 
ATOM 5128 P P     . U   B 2 8   ? 134.804 95.496  123.024 1.00 76.35  ? -29 U   B P     1 
ATOM 5129 O OP1   . U   B 2 8   ? 134.573 94.581  121.879 1.00 75.27  ? -29 U   B OP1   1 
ATOM 5130 O OP2   . U   B 2 8   ? 133.647 96.141  123.691 1.00 79.87  ? -29 U   B OP2   1 
ATOM 5131 O "O5'" . U   B 2 8   ? 135.634 94.699  124.125 1.00 76.45  ? -29 U   B "O5'" 1 
ATOM 5132 C "C5'" . U   B 2 8   ? 136.764 93.917  123.768 1.00 78.47  ? -29 U   B "C5'" 1 
ATOM 5133 C "C4'" . U   B 2 8   ? 137.344 93.208  124.966 1.00 74.09  ? -29 U   B "C4'" 1 
ATOM 5134 O "O4'" . U   B 2 8   ? 137.900 94.180  125.891 1.00 71.45  ? -29 U   B "O4'" 1 
ATOM 5135 C "C3'" . U   B 2 8   ? 136.354 92.423  125.810 1.00 78.09  ? -29 U   B "C3'" 1 
ATOM 5136 O "O3'" . U   B 2 8   ? 136.059 91.145  125.275 1.00 79.03  ? -29 U   B "O3'" 1 
ATOM 5137 C "C2'" . U   B 2 8   ? 137.040 92.374  127.168 1.00 78.02  ? -29 U   B "C2'" 1 
ATOM 5138 O "O2'" . U   B 2 8   ? 138.064 91.390  127.178 1.00 77.55  ? -29 U   B "O2'" 1 
ATOM 5139 C "C1'" . U   B 2 8   ? 137.698 93.752  127.221 1.00 74.75  ? -29 U   B "C1'" 1 
ATOM 5140 N N1    . U   B 2 8   ? 136.854 94.750  127.917 1.00 75.86  ? -29 U   B N1    1 
ATOM 5141 C C2    . U   B 2 8   ? 136.803 94.719  129.296 1.00 78.11  ? -29 U   B C2    1 
ATOM 5142 O O2    . U   B 2 8   ? 137.412 93.903  129.965 1.00 81.54  ? -29 U   B O2    1 
ATOM 5143 N N3    . U   B 2 8   ? 136.009 95.680  129.874 1.00 76.19  ? -29 U   B N3    1 
ATOM 5144 C C4    . U   B 2 8   ? 135.278 96.651  129.226 1.00 72.40  ? -29 U   B C4    1 
ATOM 5145 O O4    . U   B 2 8   ? 134.606 97.453  129.876 1.00 75.56  ? -29 U   B O4    1 
ATOM 5146 C C5    . U   B 2 8   ? 135.384 96.617  127.802 1.00 71.17  ? -29 U   B C5    1 
ATOM 5147 C C6    . U   B 2 8   ? 136.149 95.696  127.215 1.00 73.92  ? -29 U   B C6    1 
ATOM 5148 P P     . G   B 2 9   ? 134.626 90.470  125.553 1.00 98.86  ? -28 G   B P     1 
ATOM 5149 O OP1   . G   B 2 9   ? 134.538 89.231  124.739 1.00 97.65  ? -28 G   B OP1   1 
ATOM 5150 O OP2   . G   B 2 9   ? 133.586 91.519  125.411 1.00 95.11  ? -28 G   B OP2   1 
ATOM 5151 O "O5'" . G   B 2 9   ? 134.691 90.049  127.087 1.00 93.03  ? -28 G   B "O5'" 1 
ATOM 5152 C "C5'" . G   B 2 9   ? 135.642 89.099  127.541 1.00 92.36  ? -28 G   B "C5'" 1 
ATOM 5153 C "C4'" . G   B 2 9   ? 135.595 88.940  129.040 1.00 93.75  ? -28 G   B "C4'" 1 
ATOM 5154 O "O4'" . G   B 2 9   ? 136.085 90.142  129.687 1.00 92.44  ? -28 G   B "O4'" 1 
ATOM 5155 C "C3'" . G   B 2 9   ? 134.218 88.736  129.646 1.00 96.01  ? -28 G   B "C3'" 1 
ATOM 5156 O "O3'" . G   B 2 9   ? 133.754 87.403  129.523 1.00 98.11  ? -28 G   B "O3'" 1 
ATOM 5157 C "C2'" . G   B 2 9   ? 134.422 89.182  131.087 1.00 96.68  ? -28 G   B "C2'" 1 
ATOM 5158 O "O2'" . G   B 2 9   ? 135.056 88.162  131.842 1.00 97.02  ? -28 G   B "O2'" 1 
ATOM 5159 C "C1'" . G   B 2 9   ? 135.407 90.338  130.913 1.00 95.42  ? -28 G   B "C1'" 1 
ATOM 5160 N N9    . G   B 2 9   ? 134.737 91.653  130.883 1.00 95.76  ? -28 G   B N9    1 
ATOM 5161 C C8    . G   B 2 9   ? 134.510 92.422  129.769 1.00 94.85  ? -28 G   B C8    1 
ATOM 5162 N N7    . G   B 2 9   ? 133.904 93.545  130.037 1.00 96.42  ? -28 G   B N7    1 
ATOM 5163 C C5    . G   B 2 9   ? 133.722 93.521  131.411 1.00 93.30  ? -28 G   B C5    1 
ATOM 5164 C C6    . G   B 2 9   ? 133.115 94.475  132.268 1.00 93.63  ? -28 G   B C6    1 
ATOM 5165 O O6    . G   B 2 9   ? 132.610 95.560  131.963 1.00 96.65  ? -28 G   B O6    1 
ATOM 5166 N N1    . G   B 2 9   ? 133.134 94.064  133.594 1.00 94.51  ? -28 G   B N1    1 
ATOM 5167 C C2    . G   B 2 9   ? 133.669 92.882  134.042 1.00 95.05  ? -28 G   B C2    1 
ATOM 5168 N N2    . G   B 2 9   ? 133.594 92.656  135.361 1.00 97.35  ? -28 G   B N2    1 
ATOM 5169 N N3    . G   B 2 9   ? 134.236 91.982  133.251 1.00 93.56  ? -28 G   B N3    1 
ATOM 5170 C C4    . G   B 2 9   ? 134.231 92.360  131.954 1.00 94.24  ? -28 G   B C4    1 
ATOM 5171 P P     . U   B 2 10  ? 132.190 87.110  129.313 1.00 110.60 ? -27 U   B P     1 
ATOM 5172 O OP1   . U   B 2 10  ? 132.028 85.659  129.046 1.00 106.64 ? -27 U   B OP1   1 
ATOM 5173 O OP2   . U   B 2 10  ? 131.659 88.095  128.339 1.00 106.83 ? -27 U   B OP2   1 
ATOM 5174 O "O5'" . U   B 2 10  ? 131.547 87.423  130.735 1.00 106.15 ? -27 U   B "O5'" 1 
ATOM 5175 C "C5'" . U   B 2 10  ? 131.944 86.696  131.887 1.00 104.19 ? -27 U   B "C5'" 1 
ATOM 5176 C "C4'" . U   B 2 10  ? 131.494 87.377  133.155 1.00 102.58 ? -27 U   B "C4'" 1 
ATOM 5177 O "O4'" . U   B 2 10  ? 132.150 88.666  133.285 1.00 102.07 ? -27 U   B "O4'" 1 
ATOM 5178 C "C3'" . U   B 2 10  ? 130.015 87.712  133.241 1.00 103.84 ? -27 U   B "C3'" 1 
ATOM 5179 O "O3'" . U   B 2 10  ? 129.212 86.602  133.598 1.00 107.86 ? -27 U   B "O3'" 1 
ATOM 5180 C "C2'" . U   B 2 10  ? 129.994 88.837  134.263 1.00 102.70 ? -27 U   B "C2'" 1 
ATOM 5181 O "O2'" . U   B 2 10  ? 130.130 88.322  135.578 1.00 102.98 ? -27 U   B "O2'" 1 
ATOM 5182 C "C1'" . U   B 2 10  ? 131.277 89.588  133.906 1.00 104.14 ? -27 U   B "C1'" 1 
ATOM 5183 N N1    . U   B 2 10  ? 131.025 90.711  132.973 1.00 107.20 ? -27 U   B N1    1 
ATOM 5184 C C2    . U   B 2 10  ? 130.476 91.872  133.486 1.00 106.33 ? -27 U   B C2    1 
ATOM 5185 O O2    . U   B 2 10  ? 130.185 92.012  134.663 1.00 104.52 ? -27 U   B O2    1 
ATOM 5186 N N3    . U   B 2 10  ? 130.270 92.872  132.568 1.00 105.48 ? -27 U   B N3    1 
ATOM 5187 C C4    . U   B 2 10  ? 130.549 92.836  131.218 1.00 104.21 ? -27 U   B C4    1 
ATOM 5188 O O4    . U   B 2 10  ? 130.308 93.822  130.522 1.00 103.59 ? -27 U   B O4    1 
ATOM 5189 C C5    . U   B 2 10  ? 131.118 91.604  130.764 1.00 103.19 ? -27 U   B C5    1 
ATOM 5190 C C6    . U   B 2 10  ? 131.328 90.614  131.636 1.00 104.37 ? -27 U   B C6    1 
ATOM 5191 P P     . C   B 2 11  ? 127.669 86.552  133.153 1.00 113.57 ? -26 C   B P     1 
ATOM 5192 O OP1   . C   B 2 11  ? 127.165 85.175  133.386 1.00 103.15 ? -26 C   B OP1   1 
ATOM 5193 O OP2   . C   B 2 11  ? 127.562 87.153  131.799 1.00 104.77 ? -26 C   B OP2   1 
ATOM 5194 O "O5'" . C   B 2 11  ? 126.943 87.526  134.183 1.00 102.73 ? -26 C   B "O5'" 1 
ATOM 5195 C "C5'" . C   B 2 11  ? 126.999 87.274  135.578 1.00 101.31 ? -26 C   B "C5'" 1 
ATOM 5196 C "C4'" . C   B 2 11  ? 126.458 88.433  136.377 1.00 100.12 ? -26 C   B "C4'" 1 
ATOM 5197 O "O4'" . C   B 2 11  ? 127.318 89.592  136.218 1.00 102.28 ? -26 C   B "O4'" 1 
ATOM 5198 C "C3'" . C   B 2 11  ? 125.085 88.941  135.971 1.00 99.30  ? -26 C   B "C3'" 1 
ATOM 5199 O "O3'" . C   B 2 11  ? 124.028 88.146  136.474 1.00 103.52 ? -26 C   B "O3'" 1 
ATOM 5200 C "C2'" . C   B 2 11  ? 125.091 90.364  136.510 1.00 98.94  ? -26 C   B "C2'" 1 
ATOM 5201 O "O2'" . C   B 2 11  ? 124.858 90.371  137.909 1.00 99.89  ? -26 C   B "O2'" 1 
ATOM 5202 C "C1'" . C   B 2 11  ? 126.544 90.773  136.260 1.00 101.69 ? -26 C   B "C1'" 1 
ATOM 5203 N N1    . C   B 2 11  ? 126.707 91.499  134.981 1.00 101.80 ? -26 C   B N1    1 
ATOM 5204 C C2    . C   B 2 11  ? 126.325 92.842  134.907 1.00 102.86 ? -26 C   B C2    1 
ATOM 5205 O O2    . C   B 2 11  ? 125.856 93.385  135.916 1.00 105.10 ? -26 C   B O2    1 
ATOM 5206 N N3    . C   B 2 11  ? 126.469 93.509  133.739 1.00 99.73  ? -26 C   B N3    1 
ATOM 5207 C C4    . C   B 2 11  ? 126.978 92.887  132.675 1.00 98.76  ? -26 C   B C4    1 
ATOM 5208 N N4    . C   B 2 11  ? 127.109 93.578  131.540 1.00 98.52  ? -26 C   B N4    1 
ATOM 5209 C C5    . C   B 2 11  ? 127.375 91.523  132.722 1.00 101.49 ? -26 C   B C5    1 
ATOM 5210 C C6    . C   B 2 11  ? 127.226 90.876  133.883 1.00 101.56 ? -26 C   B C6    1 
ATOM 5211 P P     . U   B 2 12  ? 122.613 88.113  135.713 1.00 107.00 ? -25 U   B P     1 
ATOM 5212 O OP1   . U   B 2 12  ? 121.836 86.959  136.235 1.00 96.13  ? -25 U   B OP1   1 
ATOM 5213 O OP2   . U   B 2 12  ? 122.875 88.219  134.256 1.00 99.54  ? -25 U   B OP2   1 
ATOM 5214 O "O5'" . U   B 2 12  ? 121.891 89.452  136.185 1.00 94.91  ? -25 U   B "O5'" 1 
ATOM 5215 C "C5'" . U   B 2 12  ? 121.650 89.700  137.561 1.00 92.18  ? -25 U   B "C5'" 1 
ATOM 5216 C "C4'" . U   B 2 12  ? 121.140 91.099  137.797 1.00 92.67  ? -25 U   B "C4'" 1 
ATOM 5217 O "O4'" . U   B 2 12  ? 122.162 92.067  137.441 1.00 94.79  ? -25 U   B "O4'" 1 
ATOM 5218 C "C3'" . U   B 2 12  ? 119.936 91.518  136.969 1.00 94.56  ? -25 U   B "C3'" 1 
ATOM 5219 O "O3'" . U   B 2 12  ? 118.709 91.038  137.491 1.00 95.32  ? -25 U   B "O3'" 1 
ATOM 5220 C "C2'" . U   B 2 12  ? 120.044 93.036  136.974 1.00 94.77  ? -25 U   B "C2'" 1 
ATOM 5221 O "O2'" . U   B 2 12  ? 119.566 93.569  138.199 1.00 92.97  ? -25 U   B "O2'" 1 
ATOM 5222 C "C1'" . U   B 2 12  ? 121.558 93.234  136.919 1.00 93.89  ? -25 U   B "C1'" 1 
ATOM 5223 N N1    . U   B 2 12  ? 122.053 93.446  135.540 1.00 92.47  ? -25 U   B N1    1 
ATOM 5224 C C2    . U   B 2 12  ? 121.682 94.596  134.867 1.00 90.61  ? -25 U   B C2    1 
ATOM 5225 O O2    . U   B 2 12  ? 120.955 95.456  135.333 1.00 94.10  ? -25 U   B O2    1 
ATOM 5226 N N3    . U   B 2 12  ? 122.190 94.710  133.599 1.00 91.03  ? -25 U   B N3    1 
ATOM 5227 C C4    . U   B 2 12  ? 123.017 93.823  132.945 1.00 92.26  ? -25 U   B C4    1 
ATOM 5228 O O4    . U   B 2 12  ? 123.391 94.074  131.798 1.00 94.41  ? -25 U   B O4    1 
ATOM 5229 C C5    . U   B 2 12  ? 123.357 92.666  133.706 1.00 93.51  ? -25 U   B C5    1 
ATOM 5230 C C6    . U   B 2 12  ? 122.879 92.527  134.945 1.00 94.48  ? -25 U   B C6    1 
ATOM 5231 P P     . C   B 2 13  ? 117.458 90.789  136.515 1.00 93.93  ? -24 C   B P     1 
ATOM 5232 O OP1   . C   B 2 13  ? 116.358 90.197  137.316 1.00 84.65  ? -24 C   B OP1   1 
ATOM 5233 O OP2   . C   B 2 13  ? 117.951 90.080  135.308 1.00 87.75  ? -24 C   B OP2   1 
ATOM 5234 O "O5'" . C   B 2 13  ? 117.009 92.255  136.078 1.00 87.82  ? -24 C   B "O5'" 1 
ATOM 5235 C "C5'" . C   B 2 13  ? 116.494 93.173  137.030 1.00 83.97  ? -24 C   B "C5'" 1 
ATOM 5236 C "C4'" . C   B 2 13  ? 116.059 94.463  136.379 1.00 84.97  ? -24 C   B "C4'" 1 
ATOM 5237 O "O4'" . C   B 2 13  ? 117.217 95.209  135.920 1.00 86.93  ? -24 C   B "O4'" 1 
ATOM 5238 C "C3'" . C   B 2 13  ? 115.202 94.325  135.135 1.00 86.45  ? -24 C   B "C3'" 1 
ATOM 5239 O "O3'" . C   B 2 13  ? 113.847 94.027  135.415 1.00 85.13  ? -24 C   B "O3'" 1 
ATOM 5240 C "C2'" . C   B 2 13  ? 115.413 95.666  134.447 1.00 86.92  ? -24 C   B "C2'" 1 
ATOM 5241 O "O2'" . C   B 2 13  ? 114.652 96.682  135.082 1.00 84.02  ? -24 C   B "O2'" 1 
ATOM 5242 C "C1'" . C   B 2 13  ? 116.890 95.919  134.740 1.00 82.69  ? -24 C   B "C1'" 1 
ATOM 5243 N N1    . C   B 2 13  ? 117.757 95.439  133.638 1.00 82.26  ? -24 C   B N1    1 
ATOM 5244 C C2    . C   B 2 13  ? 117.832 96.185  132.455 1.00 84.11  ? -24 C   B C2    1 
ATOM 5245 O O2    . C   B 2 13  ? 117.177 97.233  132.364 1.00 86.24  ? -24 C   B O2    1 
ATOM 5246 N N3    . C   B 2 13  ? 118.621 95.745  131.445 1.00 85.66  ? -24 C   B N3    1 
ATOM 5247 C C4    . C   B 2 13  ? 119.311 94.613  131.585 1.00 82.45  ? -24 C   B C4    1 
ATOM 5248 N N4    . C   B 2 13  ? 120.078 94.208  130.571 1.00 82.95  ? -24 C   B N4    1 
ATOM 5249 C C5    . C   B 2 13  ? 119.248 93.835  132.775 1.00 79.65  ? -24 C   B C5    1 
ATOM 5250 C C6    . C   B 2 13  ? 118.469 94.281  133.765 1.00 80.99  ? -24 C   B C6    1 
ATOM 5251 P P     . C   B 2 14  ? 113.004 93.116  134.396 1.00 87.19  ? -23 C   B P     1 
ATOM 5252 O OP1   . C   B 2 14  ? 111.737 92.721  135.058 1.00 84.10  ? -23 C   B OP1   1 
ATOM 5253 O OP2   . C   B 2 14  ? 113.909 92.069  133.862 1.00 81.35  ? -23 C   B OP2   1 
ATOM 5254 O "O5'" . C   B 2 14  ? 112.651 94.110  133.202 1.00 84.80  ? -23 C   B "O5'" 1 
ATOM 5255 C "C5'" . C   B 2 14  ? 112.011 95.349  133.461 1.00 82.22  ? -23 C   B "C5'" 1 
ATOM 5256 C "C4'" . C   B 2 14  ? 112.052 96.264  132.261 1.00 85.46  ? -23 C   B "C4'" 1 
ATOM 5257 O "O4'" . C   B 2 14  ? 113.424 96.621  131.941 1.00 81.03  ? -23 C   B "O4'" 1 
ATOM 5258 C "C3'" . C   B 2 14  ? 111.520 95.691  130.960 1.00 87.29  ? -23 C   B "C3'" 1 
ATOM 5259 O "O3'" . C   B 2 14  ? 110.106 95.665  130.893 1.00 85.51  ? -23 C   B "O3'" 1 
ATOM 5260 C "C2'" . C   B 2 14  ? 112.173 96.591  129.921 1.00 82.27  ? -23 C   B "C2'" 1 
ATOM 5261 O "O2'" . C   B 2 14  ? 111.511 97.845  129.853 1.00 74.64  ? -23 C   B "O2'" 1 
ATOM 5262 C "C1'" . C   B 2 14  ? 113.552 96.809  130.545 1.00 75.94  ? -23 C   B "C1'" 1 
ATOM 5263 N N1    . C   B 2 14  ? 114.547 95.849  130.017 1.00 73.76  ? -23 C   B N1    1 
ATOM 5264 C C2    . C   B 2 14  ? 115.059 96.071  128.737 1.00 81.42  ? -23 C   B C2    1 
ATOM 5265 O O2    . C   B 2 14  ? 114.671 97.064  128.105 1.00 89.11  ? -23 C   B O2    1 
ATOM 5266 N N3    . C   B 2 14  ? 115.965 95.209  128.224 1.00 80.56  ? -23 C   B N3    1 
ATOM 5267 C C4    . C   B 2 14  ? 116.355 94.157  128.944 1.00 80.25  ? -23 C   B C4    1 
ATOM 5268 N N4    . C   B 2 14  ? 117.250 93.329  128.404 1.00 81.54  ? -23 C   B N4    1 
ATOM 5269 C C5    . C   B 2 14  ? 115.847 93.902  130.249 1.00 77.99  ? -23 C   B C5    1 
ATOM 5270 C C6    . C   B 2 14  ? 114.951 94.767  130.743 1.00 75.46  ? -23 C   B C6    1 
ATOM 5271 P P     . C   B 2 15  ? 109.370 94.510  130.056 1.00 86.09  ? -22 C   B P     1 
ATOM 5272 O OP1   . C   B 2 15  ? 107.935 94.502  130.434 1.00 88.20  ? -22 C   B OP1   1 
ATOM 5273 O OP2   . C   B 2 15  ? 110.173 93.268  130.185 1.00 81.61  ? -22 C   B OP2   1 
ATOM 5274 O "O5'" . C   B 2 15  ? 109.478 95.010  128.549 1.00 88.84  ? -22 C   B "O5'" 1 
ATOM 5275 C "C5'" . C   B 2 15  ? 108.982 96.286  128.174 1.00 88.78  ? -22 C   B "C5'" 1 
ATOM 5276 C "C4'" . C   B 2 15  ? 109.306 96.605  126.738 1.00 85.47  ? -22 C   B "C4'" 1 
ATOM 5277 O "O4'" . C   B 2 15  ? 110.736 96.788  126.582 1.00 80.76  ? -22 C   B "O4'" 1 
ATOM 5278 C "C3'" . C   B 2 15  ? 108.961 95.526  125.724 1.00 86.40  ? -22 C   B "C3'" 1 
ATOM 5279 O "O3'" . C   B 2 15  ? 107.593 95.533  125.359 1.00 88.34  ? -22 C   B "O3'" 1 
ATOM 5280 C "C2'" . C   B 2 15  ? 109.901 95.841  124.570 1.00 84.69  ? -22 C   B "C2'" 1 
ATOM 5281 O "O2'" . C   B 2 15  ? 109.400 96.922  123.799 1.00 91.88  ? -22 C   B "O2'" 1 
ATOM 5282 C "C1'" . C   B 2 15  ? 111.146 96.324  125.315 1.00 84.83  ? -22 C   B "C1'" 1 
ATOM 5283 N N1    . C   B 2 15  ? 112.146 95.249  125.506 1.00 85.95  ? -22 C   B N1    1 
ATOM 5284 C C2    . C   B 2 15  ? 112.905 94.825  124.412 1.00 86.56  ? -22 C   B C2    1 
ATOM 5285 O O2    . C   B 2 15  ? 112.710 95.351  123.306 1.00 90.17  ? -22 C   B O2    1 
ATOM 5286 N N3    . C   B 2 15  ? 113.824 93.851  124.588 1.00 84.75  ? -22 C   B N3    1 
ATOM 5287 C C4    . C   B 2 15  ? 114.004 93.309  125.792 1.00 84.00  ? -22 C   B C4    1 
ATOM 5288 N N4    . C   B 2 15  ? 114.923 92.351  125.911 1.00 86.59  ? -22 C   B N4    1 
ATOM 5289 C C5    . C   B 2 15  ? 113.250 93.725  126.924 1.00 83.82  ? -22 C   B C5    1 
ATOM 5290 C C6    . C   B 2 15  ? 112.343 94.691  126.736 1.00 85.42  ? -22 C   B C6    1 
ATOM 5291 P P     . A   B 2 16  ? 106.810 94.148  125.139 1.00 96.04  ? -21 A   B P     1 
ATOM 5292 O OP1   . A   B 2 16  ? 105.574 94.432  124.369 1.00 92.99  ? -21 A   B OP1   1 
ATOM 5293 O OP2   . A   B 2 16  ? 106.720 93.458  126.449 1.00 90.32  ? -21 A   B OP2   1 
ATOM 5294 O "O5'" . A   B 2 16  ? 107.789 93.305  124.208 1.00 92.92  ? -21 A   B "O5'" 1 
ATOM 5295 C "C5'" . A   B 2 16  ? 107.290 92.540  123.120 1.00 95.39  ? -21 A   B "C5'" 1 
ATOM 5296 C "C4'" . A   B 2 16  ? 108.122 92.765  121.884 1.00 90.97  ? -21 A   B "C4'" 1 
ATOM 5297 O "O4'" . A   B 2 16  ? 109.480 93.079  122.277 1.00 86.56  ? -21 A   B "O4'" 1 
ATOM 5298 C "C3'" . A   B 2 16  ? 108.267 91.578  120.940 1.00 90.14  ? -21 A   B "C3'" 1 
ATOM 5299 O "O3'" . A   B 2 16  ? 107.144 91.427  120.074 1.00 90.30  ? -21 A   B "O3'" 1 
ATOM 5300 C "C2'" . A   B 2 16  ? 109.582 91.872  120.230 1.00 89.40  ? -21 A   B "C2'" 1 
ATOM 5301 O "O2'" . A   B 2 16  ? 109.385 92.802  119.175 1.00 91.44  ? -21 A   B "O2'" 1 
ATOM 5302 C "C1'" . A   B 2 16  ? 110.384 92.560  121.330 1.00 88.95  ? -21 A   B "C1'" 1 
ATOM 5303 N N9    . A   B 2 16  ? 111.365 91.677  122.000 1.00 93.96  ? -21 A   B N9    1 
ATOM 5304 C C8    . A   B 2 16  ? 112.372 90.986  121.379 1.00 93.79  ? -21 A   B C8    1 
ATOM 5305 N N7    . A   B 2 16  ? 113.129 90.290  122.188 1.00 91.42  ? -21 A   B N7    1 
ATOM 5306 C C5    . A   B 2 16  ? 112.594 90.545  123.437 1.00 90.24  ? -21 A   B C5    1 
ATOM 5307 C C6    . A   B 2 16  ? 112.959 90.095  124.715 1.00 88.35  ? -21 A   B C6    1 
ATOM 5308 N N6    . A   B 2 16  ? 113.985 89.270  124.938 1.00 87.34  ? -21 A   B N6    1 
ATOM 5309 N N1    . A   B 2 16  ? 112.230 90.523  125.765 1.00 89.50  ? -21 A   B N1    1 
ATOM 5310 C C2    . A   B 2 16  ? 111.204 91.350  125.529 1.00 92.62  ? -21 A   B C2    1 
ATOM 5311 N N3    . A   B 2 16  ? 110.765 91.843  124.373 1.00 93.20  ? -21 A   B N3    1 
ATOM 5312 C C4    . A   B 2 16  ? 111.507 91.397  123.344 1.00 93.18  ? -21 A   B C4    1 
ATOM 5313 P P     . G   B 2 17  ? 107.143 90.473  118.767 1.00 104.33 ? -20 G   B P     1 
ATOM 5314 O OP1   . G   B 2 17  ? 108.424 90.420  118.025 1.00 102.67 ? -20 G   B OP1   1 
ATOM 5315 O OP2   . G   B 2 17  ? 105.960 90.930  118.003 1.00 104.42 ? -20 G   B OP2   1 
ATOM 5316 O "O5'" . G   B 2 17  ? 106.764 89.013  119.293 1.00 104.18 ? -20 G   B "O5'" 1 
ATOM 5317 C "C5'" . G   B 2 17  ? 107.469 88.372  120.355 1.00 103.50 ? -20 G   B "C5'" 1 
ATOM 5318 C "C4'" . G   B 2 17  ? 108.940 88.211  120.058 1.00 104.39 ? -20 G   B "C4'" 1 
ATOM 5319 O "O4'" . G   B 2 17  ? 109.696 88.621  121.228 1.00 102.19 ? -20 G   B "O4'" 1 
ATOM 5320 C "C3'" . G   B 2 17  ? 109.391 86.791  119.741 1.00 104.36 ? -20 G   B "C3'" 1 
ATOM 5321 O "O3'" . G   B 2 17  ? 110.516 86.835  118.864 1.00 103.15 ? -20 G   B "O3'" 1 
ATOM 5322 C "C2'" . G   B 2 17  ? 109.827 86.275  121.106 1.00 104.88 ? -20 G   B "C2'" 1 
ATOM 5323 O "O2'" . G   B 2 17  ? 110.749 85.207  121.063 1.00 104.26 ? -20 G   B "O2'" 1 
ATOM 5324 C "C1'" . G   B 2 17  ? 110.439 87.527  121.730 1.00 102.81 ? -20 G   B "C1'" 1 
ATOM 5325 N N9    . G   B 2 17  ? 110.339 87.562  123.189 1.00 101.58 ? -20 G   B N9    1 
ATOM 5326 C C8    . G   B 2 17  ? 109.338 88.152  123.922 1.00 100.96 ? -20 G   B C8    1 
ATOM 5327 N N7    . G   B 2 17  ? 109.514 88.033  125.209 1.00 102.68 ? -20 G   B N7    1 
ATOM 5328 C C5    . G   B 2 17  ? 110.700 87.327  125.328 1.00 104.04 ? -20 G   B C5    1 
ATOM 5329 C C6    . G   B 2 17  ? 111.401 86.899  126.485 1.00 106.03 ? -20 G   B C6    1 
ATOM 5330 O O6    . G   B 2 17  ? 111.099 87.063  127.672 1.00 106.67 ? -20 G   B O6    1 
ATOM 5331 N N1    . G   B 2 17  ? 112.564 86.214  126.151 1.00 105.07 ? -20 G   B N1    1 
ATOM 5332 C C2    . G   B 2 17  ? 112.999 85.971  124.872 1.00 102.99 ? -20 G   B C2    1 
ATOM 5333 N N2    . G   B 2 17  ? 114.149 85.291  124.758 1.00 103.23 ? -20 G   B N2    1 
ATOM 5334 N N3    . G   B 2 17  ? 112.358 86.364  123.786 1.00 100.58 ? -20 G   B N3    1 
ATOM 5335 C C4    . G   B 2 17  ? 111.228 87.035  124.089 1.00 101.76 ? -20 G   B C4    1 
ATOM 5336 P P     . A   B 2 18  ? 110.372 86.360  117.336 1.00 117.58 ? -19 A   B P     1 
ATOM 5337 O OP1   . A   B 2 18  ? 110.584 87.544  116.468 1.00 118.14 ? -19 A   B OP1   1 
ATOM 5338 O OP2   . A   B 2 18  ? 109.116 85.580  117.214 1.00 115.56 ? -19 A   B OP2   1 
ATOM 5339 O "O5'" . A   B 2 18  ? 111.597 85.361  117.124 1.00 116.27 ? -19 A   B "O5'" 1 
ATOM 5340 C "C5'" . A   B 2 18  ? 112.899 85.854  116.827 1.00 115.29 ? -19 A   B "C5'" 1 
ATOM 5341 C "C4'" . A   B 2 18  ? 113.942 85.290  117.762 1.00 118.22 ? -19 A   B "C4'" 1 
ATOM 5342 O "O4'" . A   B 2 18  ? 113.306 84.899  119.010 1.00 120.83 ? -19 A   B "O4'" 1 
ATOM 5343 C "C3'" . A   B 2 18  ? 114.685 84.053  117.257 1.00 117.39 ? -19 A   B "C3'" 1 
ATOM 5344 O "O3'" . A   B 2 18  ? 116.029 84.083  117.732 1.00 118.78 ? -19 A   B "O3'" 1 
ATOM 5345 C "C2'" . A   B 2 18  ? 113.938 82.910  117.937 1.00 116.57 ? -19 A   B "C2'" 1 
ATOM 5346 O "O2'" . A   B 2 18  ? 114.692 81.727  118.094 1.00 115.51 ? -19 A   B "O2'" 1 
ATOM 5347 C "C1'" . A   B 2 18  ? 113.583 83.539  119.282 1.00 117.96 ? -19 A   B "C1'" 1 
ATOM 5348 N N9    . A   B 2 18  ? 112.414 82.949  119.941 1.00 118.05 ? -19 A   B N9    1 
ATOM 5349 C C8    . A   B 2 18  ? 112.326 82.575  121.260 1.00 116.75 ? -19 A   B C8    1 
ATOM 5350 N N7    . A   B 2 18  ? 111.162 82.079  121.597 1.00 118.52 ? -19 A   B N7    1 
ATOM 5351 C C5    . A   B 2 18  ? 110.427 82.127  120.421 1.00 119.95 ? -19 A   B C5    1 
ATOM 5352 C C6    . A   B 2 18  ? 109.107 81.743  120.116 1.00 118.76 ? -19 A   B C6    1 
ATOM 5353 N N6    . A   B 2 18  ? 108.265 81.213  121.006 1.00 116.48 ? -19 A   B N6    1 
ATOM 5354 N N1    . A   B 2 18  ? 108.673 81.923  118.850 1.00 118.77 ? -19 A   B N1    1 
ATOM 5355 C C2    . A   B 2 18  ? 109.515 82.453  117.957 1.00 118.58 ? -19 A   B C2    1 
ATOM 5356 N N3    . A   B 2 18  ? 110.773 82.851  118.123 1.00 118.96 ? -19 A   B N3    1 
ATOM 5357 C C4    . A   B 2 18  ? 111.181 82.662  119.391 1.00 119.21 ? -19 A   B C4    1 
ATOM 5358 P P     . C   B 2 19  ? 117.253 84.087  116.692 1.00 101.45 ? -18 C   B P     1 
ATOM 5359 O OP1   . C   B 2 19  ? 117.139 82.873  115.845 1.00 91.66  ? -18 C   B OP1   1 
ATOM 5360 O OP2   . C   B 2 19  ? 118.506 84.339  117.448 1.00 90.53  ? -18 C   B OP2   1 
ATOM 5361 O "O5'" . C   B 2 19  ? 116.970 85.356  115.774 1.00 92.04  ? -18 C   B "O5'" 1 
ATOM 5362 C "C5'" . C   B 2 19  ? 117.559 85.462  114.487 1.00 89.81  ? -18 C   B "C5'" 1 
ATOM 5363 C "C4'" . C   B 2 19  ? 117.587 86.888  113.999 1.00 92.07  ? -18 C   B "C4'" 1 
ATOM 5364 O "O4'" . C   B 2 19  ? 116.249 87.446  114.013 1.00 93.22  ? -18 C   B "O4'" 1 
ATOM 5365 C "C3'" . C   B 2 19  ? 118.393 87.871  114.830 1.00 87.25  ? -18 C   B "C3'" 1 
ATOM 5366 O "O3'" . C   B 2 19  ? 119.788 87.781  114.603 1.00 83.57  ? -18 C   B "O3'" 1 
ATOM 5367 C "C2'" . C   B 2 19  ? 117.790 89.210  114.426 1.00 87.09  ? -18 C   B "C2'" 1 
ATOM 5368 O "O2'" . C   B 2 19  ? 118.303 89.631  113.172 1.00 87.00  ? -18 C   B "O2'" 1 
ATOM 5369 C "C1'" . C   B 2 19  ? 116.317 88.839  114.246 1.00 85.86  ? -18 C   B "C1'" 1 
ATOM 5370 N N1    . C   B 2 19  ? 115.501 89.183  115.434 1.00 85.52  ? -18 C   B N1    1 
ATOM 5371 C C2    . C   B 2 19  ? 114.727 90.340  115.365 1.00 87.97  ? -18 C   B C2    1 
ATOM 5372 O O2    . C   B 2 19  ? 114.750 91.006  114.320 1.00 91.03  ? -18 C   B O2    1 
ATOM 5373 N N3    . C   B 2 19  ? 113.968 90.702  116.421 1.00 88.98  ? -18 C   B N3    1 
ATOM 5374 C C4    . C   B 2 19  ? 113.971 89.956  117.524 1.00 86.24  ? -18 C   B C4    1 
ATOM 5375 N N4    . C   B 2 19  ? 113.207 90.351  118.541 1.00 84.41  ? -18 C   B N4    1 
ATOM 5376 C C5    . C   B 2 19  ? 114.757 88.773  117.630 1.00 87.87  ? -18 C   B C5    1 
ATOM 5377 C C6    . C   B 2 19  ? 115.501 88.427  116.572 1.00 88.51  ? -18 C   B C6    1 
ATOM 5378 P P     . G   B 2 20  ? 120.814 88.322  115.713 1.00 79.48  ? -17 G   B P     1 
ATOM 5379 O OP1   . G   B 2 20  ? 122.190 88.016  115.250 1.00 80.68  ? -17 G   B OP1   1 
ATOM 5380 O OP2   . G   B 2 20  ? 120.361 87.832  117.039 1.00 74.79  ? -17 G   B OP2   1 
ATOM 5381 O "O5'" . G   B 2 20  ? 120.616 89.901  115.672 1.00 73.26  ? -17 G   B "O5'" 1 
ATOM 5382 C "C5'" . G   B 2 20  ? 120.595 90.672  116.863 1.00 73.90  ? -17 G   B "C5'" 1 
ATOM 5383 C "C4'" . G   B 2 20  ? 119.576 91.779  116.778 1.00 71.33  ? -17 G   B "C4'" 1 
ATOM 5384 O "O4'" . G   B 2 20  ? 118.253 91.248  117.064 1.00 73.38  ? -17 G   B "O4'" 1 
ATOM 5385 C "C3'" . G   B 2 20  ? 119.733 92.915  117.775 1.00 70.27  ? -17 G   B "C3'" 1 
ATOM 5386 O "O3'" . G   B 2 20  ? 120.716 93.862  117.402 1.00 71.09  ? -17 G   B "O3'" 1 
ATOM 5387 C "C2'" . G   B 2 20  ? 118.325 93.481  117.842 1.00 72.49  ? -17 G   B "C2'" 1 
ATOM 5388 O "O2'" . G   B 2 20  ? 118.040 94.241  116.679 1.00 70.43  ? -17 G   B "O2'" 1 
ATOM 5389 C "C1'" . G   B 2 20  ? 117.502 92.200  117.788 1.00 73.28  ? -17 G   B "C1'" 1 
ATOM 5390 N N9    . G   B 2 20  ? 117.267 91.667  119.141 1.00 75.61  ? -17 G   B N9    1 
ATOM 5391 C C8    . G   B 2 20  ? 117.830 90.545  119.697 1.00 76.23  ? -17 G   B C8    1 
ATOM 5392 N N7    . G   B 2 20  ? 117.438 90.328  120.921 1.00 76.75  ? -17 G   B N7    1 
ATOM 5393 C C5    . G   B 2 20  ? 116.570 91.375  121.193 1.00 74.65  ? -17 G   B C5    1 
ATOM 5394 C C6    . G   B 2 20  ? 115.836 91.678  122.364 1.00 73.84  ? -17 G   B C6    1 
ATOM 5395 O O6    . G   B 2 20  ? 115.793 91.065  123.437 1.00 74.83  ? -17 G   B O6    1 
ATOM 5396 N N1    . G   B 2 20  ? 115.081 92.833  122.205 1.00 70.04  ? -17 G   B N1    1 
ATOM 5397 C C2    . G   B 2 20  ? 115.036 93.604  121.071 1.00 68.46  ? -17 G   B C2    1 
ATOM 5398 N N2    . G   B 2 20  ? 114.248 94.685  121.109 1.00 71.93  ? -17 G   B N2    1 
ATOM 5399 N N3    . G   B 2 20  ? 115.719 93.333  119.973 1.00 67.29  ? -17 G   B N3    1 
ATOM 5400 C C4    . G   B 2 20  ? 116.457 92.213  120.105 1.00 71.85  ? -17 G   B C4    1 
ATOM 5401 P P     . G   B 2 21  ? 121.622 94.557  118.532 1.00 68.71  ? -16 G   B P     1 
ATOM 5402 O OP1   . G   B 2 21  ? 122.763 95.232  117.864 1.00 62.07  ? -16 G   B OP1   1 
ATOM 5403 O OP2   . G   B 2 21  ? 121.877 93.552  119.593 1.00 67.54  ? -16 G   B OP2   1 
ATOM 5404 O "O5'" . G   B 2 21  ? 120.675 95.680  119.146 1.00 62.19  ? -16 G   B "O5'" 1 
ATOM 5405 C "C5'" . G   B 2 21  ? 120.196 96.743  118.340 1.00 61.75  ? -16 G   B "C5'" 1 
ATOM 5406 C "C4'" . G   B 2 21  ? 119.127 97.538  119.044 1.00 54.80  ? -16 G   B "C4'" 1 
ATOM 5407 O "O4'" . G   B 2 21  ? 118.046 96.659  119.452 1.00 56.79  ? -16 G   B "O4'" 1 
ATOM 5408 C "C3'" . G   B 2 21  ? 119.539 98.223  120.336 1.00 63.62  ? -16 G   B "C3'" 1 
ATOM 5409 O "O3'" . G   B 2 21  ? 120.257 99.427  120.137 1.00 62.58  ? -16 G   B "O3'" 1 
ATOM 5410 C "C2'" . G   B 2 21  ? 118.202 98.412  121.036 1.00 66.74  ? -16 G   B "C2'" 1 
ATOM 5411 O "O2'" . G   B 2 21  ? 117.474 99.476  120.441 1.00 61.84  ? -16 G   B "O2'" 1 
ATOM 5412 C "C1'" . G   B 2 21  ? 117.505 97.104  120.680 1.00 64.51  ? -16 G   B "C1'" 1 
ATOM 5413 N N9    . G   B 2 21  ? 117.753 96.069  121.700 1.00 67.56  ? -16 G   B N9    1 
ATOM 5414 C C8    . G   B 2 21  ? 118.596 94.992  121.591 1.00 65.40  ? -16 G   B C8    1 
ATOM 5415 N N7    . G   B 2 21  ? 118.616 94.247  122.660 1.00 63.45  ? -16 G   B N7    1 
ATOM 5416 C C5    . G   B 2 21  ? 117.738 94.871  123.530 1.00 62.82  ? -16 G   B C5    1 
ATOM 5417 C C6    . G   B 2 21  ? 117.352 94.519  124.847 1.00 69.66  ? -16 G   B C6    1 
ATOM 5418 O O6    . G   B 2 21  ? 117.726 93.552  125.523 1.00 70.96  ? -16 G   B O6    1 
ATOM 5419 N N1    . G   B 2 21  ? 116.436 95.424  125.371 1.00 67.17  ? -16 G   B N1    1 
ATOM 5420 C C2    . G   B 2 21  ? 115.955 96.529  124.713 1.00 59.41  ? -16 G   B C2    1 
ATOM 5421 N N2    . G   B 2 21  ? 115.076 97.290  125.379 1.00 57.18  ? -16 G   B N2    1 
ATOM 5422 N N3    . G   B 2 21  ? 116.308 96.866  123.484 1.00 58.71  ? -16 G   B N3    1 
ATOM 5423 C C4    . G   B 2 21  ? 117.196 96.000  122.957 1.00 61.68  ? -16 G   B C4    1 
ATOM 5424 P P     . G   B 2 22  ? 121.340 99.902  121.224 1.00 47.45  ? -15 G   B P     1 
ATOM 5425 O OP1   . G   B 2 22  ? 122.111 101.031 120.649 1.00 60.49  ? -15 G   B OP1   1 
ATOM 5426 O OP2   . G   B 2 22  ? 122.057 98.701  121.714 1.00 55.32  ? -15 G   B OP2   1 
ATOM 5427 O "O5'" . G   B 2 22  ? 120.460 100.467 122.422 1.00 55.99  ? -15 G   B "O5'" 1 
ATOM 5428 C "C5'" . G   B 2 22  ? 119.604 101.583 122.230 1.00 55.16  ? -15 G   B "C5'" 1 
ATOM 5429 C "C4'" . G   B 2 22  ? 118.660 101.768 123.390 1.00 55.42  ? -15 G   B "C4'" 1 
ATOM 5430 O "O4'" . G   B 2 22  ? 117.942 100.533 123.640 1.00 61.12  ? -15 G   B "O4'" 1 
ATOM 5431 C "C3'" . G   B 2 22  ? 119.297 102.093 124.731 1.00 59.86  ? -15 G   B "C3'" 1 
ATOM 5432 O "O3'" . G   B 2 22  ? 119.659 103.456 124.867 1.00 60.77  ? -15 G   B "O3'" 1 
ATOM 5433 C "C2'" . G   B 2 22  ? 118.227 101.642 125.715 1.00 60.27  ? -15 G   B "C2'" 1 
ATOM 5434 O "O2'" . G   B 2 22  ? 117.172 102.591 125.777 1.00 59.14  ? -15 G   B "O2'" 1 
ATOM 5435 C "C1'" . G   B 2 22  ? 117.701 100.389 125.024 1.00 58.42  ? -15 G   B "C1'" 1 
ATOM 5436 N N9    . G   B 2 22  ? 118.375 99.166  125.499 1.00 58.82  ? -15 G   B N9    1 
ATOM 5437 C C8    . G   B 2 22  ? 119.256 98.386  124.790 1.00 61.77  ? -15 G   B C8    1 
ATOM 5438 N N7    . G   B 2 22  ? 119.685 97.356  125.463 1.00 61.46  ? -15 G   B N7    1 
ATOM 5439 C C5    . G   B 2 22  ? 119.049 97.456  126.692 1.00 61.21  ? -15 G   B C5    1 
ATOM 5440 C C6    . G   B 2 22  ? 119.123 96.620  127.833 1.00 60.21  ? -15 G   B C6    1 
ATOM 5441 O O6    . G   B 2 22  ? 119.790 95.589  127.986 1.00 57.09  ? -15 G   B O6    1 
ATOM 5442 N N1    . G   B 2 22  ? 118.317 97.085  128.865 1.00 63.06  ? -15 G   B N1    1 
ATOM 5443 C C2    . G   B 2 22  ? 117.537 98.214  128.805 1.00 59.45  ? -15 G   B C2    1 
ATOM 5444 N N2    . G   B 2 22  ? 116.820 98.511  129.897 1.00 57.77  ? -15 G   B N2    1 
ATOM 5445 N N3    . G   B 2 22  ? 117.458 99.001  127.745 1.00 55.70  ? -15 G   B N3    1 
ATOM 5446 C C4    . G   B 2 22  ? 118.235 98.568  126.730 1.00 58.78  ? -15 G   B C4    1 
ATOM 5447 P P     . A   B 2 23  ? 120.983 103.862 125.683 1.00 57.33  ? -14 A   B P     1 
ATOM 5448 O OP1   . A   B 2 23  ? 121.423 105.209 125.251 1.00 63.99  ? -14 A   B OP1   1 
ATOM 5449 O OP2   . A   B 2 23  ? 121.924 102.721 125.606 1.00 56.23  ? -14 A   B OP2   1 
ATOM 5450 O "O5'" . A   B 2 23  ? 120.493 103.975 127.190 1.00 60.63  ? -14 A   B "O5'" 1 
ATOM 5451 C "C5'" . A   B 2 23  ? 120.461 102.827 128.019 1.00 64.96  ? -14 A   B "C5'" 1 
ATOM 5452 C "C4'" . A   B 2 23  ? 119.733 103.081 129.310 1.00 59.96  ? -14 A   B "C4'" 1 
ATOM 5453 O "O4'" . A   B 2 23  ? 119.020 101.883 129.706 1.00 54.06  ? -14 A   B "O4'" 1 
ATOM 5454 C "C3'" . A   B 2 23  ? 120.623 103.402 130.499 1.00 63.44  ? -14 A   B "C3'" 1 
ATOM 5455 O "O3'" . A   B 2 23  ? 120.985 104.771 130.549 1.00 61.06  ? -14 A   B "O3'" 1 
ATOM 5456 C "C2'" . A   B 2 23  ? 119.790 102.942 131.688 1.00 67.73  ? -14 A   B "C2'" 1 
ATOM 5457 O "O2'" . A   B 2 23  ? 118.823 103.920 132.033 1.00 73.96  ? -14 A   B "O2'" 1 
ATOM 5458 C "C1'" . A   B 2 23  ? 119.065 101.730 131.106 1.00 60.52  ? -14 A   B "C1'" 1 
ATOM 5459 N N9    . A   B 2 23  ? 119.733 100.453 131.424 1.00 65.85  ? -14 A   B N9    1 
ATOM 5460 C C8    . A   B 2 23  ? 119.626 99.742  132.595 1.00 65.01  ? -14 A   B C8    1 
ATOM 5461 N N7    . A   B 2 23  ? 120.330 98.638  132.612 1.00 66.39  ? -14 A   B N7    1 
ATOM 5462 C C5    . A   B 2 23  ? 120.946 98.617  131.370 1.00 63.70  ? -14 A   B C5    1 
ATOM 5463 C C6    . A   B 2 23  ? 121.826 97.703  130.769 1.00 58.75  ? -14 A   B C6    1 
ATOM 5464 N N6    . A   B 2 23  ? 122.255 96.589  131.362 1.00 62.79  ? -14 A   B N6    1 
ATOM 5465 N N1    . A   B 2 23  ? 122.260 97.968  129.521 1.00 59.36  ? -14 A   B N1    1 
ATOM 5466 C C2    . A   B 2 23  ? 121.832 99.081  128.922 1.00 60.77  ? -14 A   B C2    1 
ATOM 5467 N N3    . A   B 2 23  ? 121.008 100.014 129.384 1.00 57.12  ? -14 A   B N3    1 
ATOM 5468 C C4    . A   B 2 23  ? 120.592 99.729  130.628 1.00 62.52  ? -14 A   B C4    1 
ATOM 5469 P P     . G   B 2 24  ? 122.418 105.200 131.125 1.00 65.94  ? -13 G   B P     1 
ATOM 5470 O OP1   . G   B 2 24  ? 122.424 106.672 131.303 1.00 65.96  ? -13 G   B OP1   1 
ATOM 5471 O OP2   . G   B 2 24  ? 123.462 104.556 130.291 1.00 74.77  ? -13 G   B OP2   1 
ATOM 5472 O "O5'" . G   B 2 24  ? 122.452 104.530 132.567 1.00 73.47  ? -13 G   B "O5'" 1 
ATOM 5473 C "C5'" . G   B 2 24  ? 123.659 104.013 133.104 1.00 76.08  ? -13 G   B "C5'" 1 
ATOM 5474 C "C4'" . G   B 2 24  ? 123.385 103.016 134.199 1.00 75.74  ? -13 G   B "C4'" 1 
ATOM 5475 O "O4'" . G   B 2 24  ? 122.730 101.844 133.649 1.00 74.58  ? -13 G   B "O4'" 1 
ATOM 5476 C "C3'" . G   B 2 24  ? 124.609 102.453 134.902 1.00 77.26  ? -13 G   B "C3'" 1 
ATOM 5477 O "O3'" . G   B 2 24  ? 125.126 103.327 135.888 1.00 75.66  ? -13 G   B "O3'" 1 
ATOM 5478 C "C2'" . G   B 2 24  ? 124.092 101.133 135.456 1.00 79.07  ? -13 G   B "C2'" 1 
ATOM 5479 O "O2'" . G   B 2 24  ? 123.317 101.349 136.626 1.00 80.11  ? -13 G   B "O2'" 1 
ATOM 5480 C "C1'" . G   B 2 24  ? 123.156 100.686 134.336 1.00 75.51  ? -13 G   B "C1'" 1 
ATOM 5481 N N9    . G   B 2 24  ? 123.838 99.796  133.380 1.00 72.79  ? -13 G   B N9    1 
ATOM 5482 C C8    . G   B 2 24  ? 124.206 100.094 132.092 1.00 72.25  ? -13 G   B C8    1 
ATOM 5483 N N7    . G   B 2 24  ? 124.796 99.100  131.488 1.00 73.84  ? -13 G   B N7    1 
ATOM 5484 C C5    . G   B 2 24  ? 124.819 98.088  132.436 1.00 74.29  ? -13 G   B C5    1 
ATOM 5485 C C6    . G   B 2 24  ? 125.335 96.769  132.357 1.00 76.60  ? -13 G   B C6    1 
ATOM 5486 O O6    . G   B 2 24  ? 125.892 96.224  131.398 1.00 76.34  ? -13 G   B O6    1 
ATOM 5487 N N1    . G   B 2 24  ? 125.151 96.075  133.546 1.00 77.66  ? -13 G   B N1    1 
ATOM 5488 C C2    . G   B 2 24  ? 124.548 96.582  134.671 1.00 76.09  ? -13 G   B C2    1 
ATOM 5489 N N2    . G   B 2 24  ? 124.458 95.765  135.729 1.00 76.61  ? -13 G   B N2    1 
ATOM 5490 N N3    . G   B 2 24  ? 124.065 97.810  134.756 1.00 73.44  ? -13 G   B N3    1 
ATOM 5491 C C4    . G   B 2 24  ? 124.231 98.500  133.611 1.00 74.09  ? -13 G   B C4    1 
ATOM 5492 P P     . G   B 2 25  ? 126.699 103.333 136.213 1.00 87.06  ? -12 G   B P     1 
ATOM 5493 O OP1   . G   B 2 25  ? 126.990 104.515 137.060 1.00 89.47  ? -12 G   B OP1   1 
ATOM 5494 O OP2   . G   B 2 25  ? 127.439 103.142 134.940 1.00 86.82  ? -12 G   B OP2   1 
ATOM 5495 O "O5'" . G   B 2 25  ? 126.906 102.027 137.097 1.00 89.75  ? -12 G   B "O5'" 1 
ATOM 5496 C "C5'" . G   B 2 25  ? 126.101 101.792 138.243 1.00 88.98  ? -12 G   B "C5'" 1 
ATOM 5497 C "C4'" . G   B 2 25  ? 126.495 100.511 138.930 1.00 88.97  ? -12 G   B "C4'" 1 
ATOM 5498 O "O4'" . G   B 2 25  ? 126.015 99.371  138.181 1.00 86.88  ? -12 G   B "O4'" 1 
ATOM 5499 C "C3'" . G   B 2 25  ? 127.989 100.276 139.048 1.00 89.46  ? -12 G   B "C3'" 1 
ATOM 5500 O "O3'" . G   B 2 25  ? 128.551 100.991 140.132 1.00 91.70  ? -12 G   B "O3'" 1 
ATOM 5501 C "C2'" . G   B 2 25  ? 128.085 98.762  139.189 1.00 89.01  ? -12 G   B "C2'" 1 
ATOM 5502 O "O2'" . G   B 2 25  ? 127.840 98.364  140.530 1.00 89.25  ? -12 G   B "O2'" 1 
ATOM 5503 C "C1'" . G   B 2 25  ? 126.914 98.292  138.323 1.00 88.86  ? -12 G   B "C1'" 1 
ATOM 5504 N N9    . G   B 2 25  ? 127.326 97.832  136.981 1.00 87.67  ? -12 G   B N9    1 
ATOM 5505 C C8    . G   B 2 25  ? 127.105 98.465  135.785 1.00 85.29  ? -12 G   B C8    1 
ATOM 5506 N N7    . G   B 2 25  ? 127.568 97.803  134.759 1.00 84.46  ? -12 G   B N7    1 
ATOM 5507 C C5    . G   B 2 25  ? 128.122 96.656  135.311 1.00 87.32  ? -12 G   B C5    1 
ATOM 5508 C C6    . G   B 2 25  ? 128.776 95.560  134.691 1.00 89.40  ? -12 G   B C6    1 
ATOM 5509 O O6    . G   B 2 25  ? 129.004 95.375  133.490 1.00 90.12  ? -12 G   B O6    1 
ATOM 5510 N N1    . G   B 2 25  ? 129.185 94.615  135.623 1.00 88.83  ? -12 G   B N1    1 
ATOM 5511 C C2    . G   B 2 25  ? 128.989 94.709  136.978 1.00 88.44  ? -12 G   B C2    1 
ATOM 5512 N N2    . G   B 2 25  ? 129.457 93.691  137.714 1.00 88.93  ? -12 G   B N2    1 
ATOM 5513 N N3    . G   B 2 25  ? 128.381 95.725  137.568 1.00 91.15  ? -12 G   B N3    1 
ATOM 5514 C C4    . G   B 2 25  ? 127.976 96.657  136.681 1.00 89.83  ? -12 G   B C4    1 
ATOM 5515 P P     . C   B 2 26  ? 130.139 101.154 140.250 1.00 99.08  ? -11 C   B P     1 
ATOM 5516 O OP1   . C   B 2 26  ? 130.423 102.230 141.233 1.00 97.19  ? -11 C   B OP1   1 
ATOM 5517 O OP2   . C   B 2 26  ? 130.698 101.251 138.879 1.00 97.49  ? -11 C   B OP2   1 
ATOM 5518 O "O5'" . C   B 2 26  ? 130.608 99.769  140.878 1.00 98.02  ? -11 C   B "O5'" 1 
ATOM 5519 C "C5'" . C   B 2 26  ? 131.984 99.467  140.996 1.00 97.66  ? -11 C   B "C5'" 1 
ATOM 5520 C "C4'" . C   B 2 26  ? 132.246 97.988  140.902 1.00 96.63  ? -11 C   B "C4'" 1 
ATOM 5521 O "O4'" . C   B 2 26  ? 131.291 97.353  140.010 1.00 92.22  ? -11 C   B "O4'" 1 
ATOM 5522 C "C3'" . C   B 2 26  ? 133.596 97.613  140.321 1.00 96.27  ? -11 C   B "C3'" 1 
ATOM 5523 O "O3'" . C   B 2 26  ? 134.641 97.721  141.267 1.00 95.82  ? -11 C   B "O3'" 1 
ATOM 5524 C "C2'" . C   B 2 26  ? 133.359 96.199  139.812 1.00 98.92  ? -11 C   B "C2'" 1 
ATOM 5525 O "O2'" . C   B 2 26  ? 133.398 95.268  140.883 1.00 99.76  ? -11 C   B "O2'" 1 
ATOM 5526 C "C1'" . C   B 2 26  ? 131.916 96.296  139.311 1.00 95.74  ? -11 C   B "C1'" 1 
ATOM 5527 N N1    . C   B 2 26  ? 131.822 96.575  137.856 1.00 96.16  ? -11 C   B N1    1 
ATOM 5528 C C2    . C   B 2 26  ? 132.336 95.698  136.884 1.00 95.91  ? -11 C   B C2    1 
ATOM 5529 O O2    . C   B 2 26  ? 132.925 94.662  137.231 1.00 95.86  ? -11 C   B O2    1 
ATOM 5530 N N3    . C   B 2 26  ? 132.205 96.020  135.574 1.00 96.97  ? -11 C   B N3    1 
ATOM 5531 C C4    . C   B 2 26  ? 131.578 97.139  135.211 1.00 95.66  ? -11 C   B C4    1 
ATOM 5532 N N4    . C   B 2 26  ? 131.459 97.422  133.913 1.00 96.79  ? -11 C   B N4    1 
ATOM 5533 C C5    . C   B 2 26  ? 131.033 98.034  136.172 1.00 94.64  ? -11 C   B C5    1 
ATOM 5534 C C6    . C   B 2 26  ? 131.173 97.711  137.460 1.00 96.23  ? -11 C   B C6    1 
ATOM 5535 P P     . A   B 2 27  ? 135.985 98.512  140.891 1.00 100.82 ? -10 A   B P     1 
ATOM 5536 O OP1   . A   B 2 27  ? 136.642 98.938  142.152 1.00 100.45 ? -10 A   B OP1   1 
ATOM 5537 O OP2   . A   B 2 27  ? 135.651 99.525  139.859 1.00 96.75  ? -10 A   B OP2   1 
ATOM 5538 O "O5'" . A   B 2 27  ? 136.889 97.394  140.212 1.00 95.40  ? -10 A   B "O5'" 1 
ATOM 5539 C "C5'" . A   B 2 27  ? 137.003 96.111  140.805 1.00 95.71  ? -10 A   B "C5'" 1 
ATOM 5540 C "C4'" . A   B 2 27  ? 137.402 95.074  139.789 1.00 95.76  ? -10 A   B "C4'" 1 
ATOM 5541 O "O4'" . A   B 2 27  ? 136.271 94.744  138.944 1.00 96.62  ? -10 A   B "O4'" 1 
ATOM 5542 C "C3'" . A   B 2 27  ? 138.481 95.495  138.809 1.00 96.35  ? -10 A   B "C3'" 1 
ATOM 5543 O "O3'" . A   B 2 27  ? 139.784 95.411  139.358 1.00 98.95  ? -10 A   B "O3'" 1 
ATOM 5544 C "C2'" . A   B 2 27  ? 138.246 94.553  137.636 1.00 98.66  ? -10 A   B "C2'" 1 
ATOM 5545 O "O2'" . A   B 2 27  ? 138.783 93.267  137.909 1.00 96.06  ? -10 A   B "O2'" 1 
ATOM 5546 C "C1'" . A   B 2 27  ? 136.720 94.449  137.638 1.00 99.41  ? -10 A   B "C1'" 1 
ATOM 5547 N N9    . A   B 2 27  ? 136.095 95.397  136.697 1.00 99.63  ? -10 A   B N9    1 
ATOM 5548 C C8    . A   B 2 27  ? 135.343 96.506  136.991 1.00 97.32  ? -10 A   B C8    1 
ATOM 5549 N N7    . A   B 2 27  ? 134.913 97.152  135.935 1.00 95.19  ? -10 A   B N7    1 
ATOM 5550 C C5    . A   B 2 27  ? 135.422 96.422  134.871 1.00 95.80  ? -10 A   B C5    1 
ATOM 5551 C C6    . A   B 2 27  ? 135.328 96.586  133.478 1.00 95.37  ? -10 A   B C6    1 
ATOM 5552 N N6    . A   B 2 27  ? 134.660 97.580  132.890 1.00 94.81  ? -10 A   B N6    1 
ATOM 5553 N N1    . A   B 2 27  ? 135.954 95.680  132.696 1.00 96.53  ? -10 A   B N1    1 
ATOM 5554 C C2    . A   B 2 27  ? 136.623 94.680  133.284 1.00 95.49  ? -10 A   B C2    1 
ATOM 5555 N N3    . A   B 2 27  ? 136.784 94.422  134.578 1.00 96.14  ? -10 A   B N3    1 
ATOM 5556 C C4    . A   B 2 27  ? 136.150 95.339  135.326 1.00 97.22  ? -10 A   B C4    1 
ATOM 5557 P P     . G   B 2 28  ? 140.824 96.615  139.146 1.00 103.56 ? -9  G   B P     1 
ATOM 5558 O OP1   . G   B 2 28  ? 141.316 97.052  140.477 1.00 94.52  ? -9  G   B OP1   1 
ATOM 5559 O OP2   . G   B 2 28  ? 140.196 97.607  138.236 1.00 97.46  ? -9  G   B OP2   1 
ATOM 5560 O "O5'" . G   B 2 28  ? 142.034 95.936  138.367 1.00 99.75  ? -9  G   B "O5'" 1 
ATOM 5561 C "C5'" . G   B 2 28  ? 142.447 96.423  137.101 1.00 94.14  ? -9  G   B "C5'" 1 
ATOM 5562 C "C4'" . G   B 2 28  ? 142.180 95.419  136.010 1.00 93.62  ? -9  G   B "C4'" 1 
ATOM 5563 O "O4'" . G   B 2 28  ? 140.749 95.233  135.850 1.00 96.04  ? -9  G   B "O4'" 1 
ATOM 5564 C "C3'" . G   B 2 28  ? 142.663 95.814  134.626 1.00 96.38  ? -9  G   B "C3'" 1 
ATOM 5565 O "O3'" . G   B 2 28  ? 144.039 95.543  134.434 1.00 97.87  ? -9  G   B "O3'" 1 
ATOM 5566 C "C2'" . G   B 2 28  ? 141.748 95.013  133.709 1.00 97.79  ? -9  G   B "C2'" 1 
ATOM 5567 O "O2'" . G   B 2 28  ? 142.175 93.661  133.632 1.00 94.09  ? -9  G   B "O2'" 1 
ATOM 5568 C "C1'" . G   B 2 28  ? 140.431 95.058  134.485 1.00 97.71  ? -9  G   B "C1'" 1 
ATOM 5569 N N9    . G   B 2 28  ? 139.561 96.179  134.072 1.00 95.56  ? -9  G   B N9    1 
ATOM 5570 C C8    . G   B 2 28  ? 138.910 97.013  134.946 1.00 92.69  ? -9  G   B C8    1 
ATOM 5571 N N7    . G   B 2 28  ? 138.192 97.925  134.359 1.00 91.66  ? -9  G   B N7    1 
ATOM 5572 C C5    . G   B 2 28  ? 138.375 97.681  133.008 1.00 95.07  ? -9  G   B C5    1 
ATOM 5573 C C6    . G   B 2 28  ? 137.835 98.361  131.888 1.00 97.00  ? -9  G   B C6    1 
ATOM 5574 O O6    . G   B 2 28  ? 137.074 99.336  131.886 1.00 97.11  ? -9  G   B O6    1 
ATOM 5575 N N1    . G   B 2 28  ? 138.263 97.805  130.688 1.00 96.72  ? -9  G   B N1    1 
ATOM 5576 C C2    . G   B 2 28  ? 139.104 96.726  130.580 1.00 95.27  ? -9  G   B C2    1 
ATOM 5577 N N2    . G   B 2 28  ? 139.413 96.326  129.338 1.00 91.61  ? -9  G   B N2    1 
ATOM 5578 N N3    . G   B 2 28  ? 139.610 96.081  131.621 1.00 96.05  ? -9  G   B N3    1 
ATOM 5579 C C4    . G   B 2 28  ? 139.213 96.604  132.803 1.00 95.27  ? -9  G   B C4    1 
ATOM 5580 P P     . A   B 2 29  ? 145.116 96.733  134.493 1.00 98.88  ? -8  A   B P     1 
ATOM 5581 O OP1   . A   B 2 29  ? 146.277 96.270  135.293 1.00 90.06  ? -8  A   B OP1   1 
ATOM 5582 O OP2   . A   B 2 29  ? 144.412 97.981  134.885 1.00 91.22  ? -8  A   B OP2   1 
ATOM 5583 O "O5'" . A   B 2 29  ? 145.593 96.886  132.984 1.00 89.50  ? -8  A   B "O5'" 1 
ATOM 5584 C "C5'" . A   B 2 29  ? 146.055 95.760  132.254 1.00 86.89  ? -8  A   B "C5'" 1 
ATOM 5585 C "C4'" . A   B 2 29  ? 145.608 95.817  130.815 1.00 87.35  ? -8  A   B "C4'" 1 
ATOM 5586 O "O4'" . A   B 2 29  ? 144.165 95.694  130.742 1.00 87.96  ? -8  A   B "O4'" 1 
ATOM 5587 C "C3'" . A   B 2 29  ? 145.909 97.113  130.081 1.00 85.48  ? -8  A   B "C3'" 1 
ATOM 5588 O "O3'" . A   B 2 29  ? 147.241 97.169  129.602 1.00 83.44  ? -8  A   B "O3'" 1 
ATOM 5589 C "C2'" . A   B 2 29  ? 144.865 97.119  128.973 1.00 88.36  ? -8  A   B "C2'" 1 
ATOM 5590 O "O2'" . A   B 2 29  ? 145.267 96.281  127.900 1.00 90.72  ? -8  A   B "O2'" 1 
ATOM 5591 C "C1'" . A   B 2 29  ? 143.671 96.468  129.670 1.00 89.22  ? -8  A   B "C1'" 1 
ATOM 5592 N N9    . A   B 2 29  ? 142.707 97.452  130.202 1.00 89.20  ? -8  A   B N9    1 
ATOM 5593 C C8    . A   B 2 29  ? 142.226 97.525  131.484 1.00 86.15  ? -8  A   B C8    1 
ATOM 5594 N N7    . A   B 2 29  ? 141.364 98.491  131.681 1.00 82.76  ? -8  A   B N7    1 
ATOM 5595 C C5    . A   B 2 29  ? 141.263 99.096  130.439 1.00 83.06  ? -8  A   B C5    1 
ATOM 5596 C C6    . A   B 2 29  ? 140.505 100.186 129.987 1.00 82.62  ? -8  A   B C6    1 
ATOM 5597 N N6    . A   B 2 29  ? 139.676 100.887 130.763 1.00 81.28  ? -8  A   B N6    1 
ATOM 5598 N N1    . A   B 2 29  ? 140.631 100.540 128.690 1.00 86.72  ? -8  A   B N1    1 
ATOM 5599 C C2    . A   B 2 29  ? 141.459 99.836  127.909 1.00 86.40  ? -8  A   B C2    1 
ATOM 5600 N N3    . A   B 2 29  ? 142.221 98.792  128.221 1.00 88.50  ? -8  A   B N3    1 
ATOM 5601 C C4    . A   B 2 29  ? 142.076 98.464  129.516 1.00 87.13  ? -8  A   B C4    1 
ATOM 5602 P P     . A   B 2 30  ? 148.229 98.339  130.086 1.00 83.80  ? -7  A   B P     1 
ATOM 5603 O OP1   . A   B 2 30  ? 149.600 97.781  130.169 1.00 81.79  ? -7  A   B OP1   1 
ATOM 5604 O OP2   . A   B 2 30  ? 147.626 98.983  131.280 1.00 80.47  ? -7  A   B OP2   1 
ATOM 5605 O "O5'" . A   B 2 30  ? 148.193 99.388  128.890 1.00 84.19  ? -7  A   B "O5'" 1 
ATOM 5606 C "C5'" . A   B 2 30  ? 148.421 98.979  127.548 1.00 82.19  ? -7  A   B "C5'" 1 
ATOM 5607 C "C4'" . A   B 2 30  ? 147.638 99.830  126.581 1.00 83.84  ? -7  A   B "C4'" 1 
ATOM 5608 O "O4'" . A   B 2 30  ? 146.225 99.671  126.835 1.00 83.19  ? -7  A   B "O4'" 1 
ATOM 5609 C "C3'" . A   B 2 30  ? 147.880 101.329 126.680 1.00 80.94  ? -7  A   B "C3'" 1 
ATOM 5610 O "O3'" . A   B 2 30  ? 149.006 101.730 125.921 1.00 78.71  ? -7  A   B "O3'" 1 
ATOM 5611 C "C2'" . A   B 2 30  ? 146.573 101.934 126.176 1.00 78.84  ? -7  A   B "C2'" 1 
ATOM 5612 O "O2'" . A   B 2 30  ? 146.584 102.035 124.760 1.00 82.86  ? -7  A   B "O2'" 1 
ATOM 5613 C "C1'" . A   B 2 30  ? 145.546 100.875 126.575 1.00 80.76  ? -7  A   B "C1'" 1 
ATOM 5614 N N9    . A   B 2 30  ? 144.720 101.227 127.748 1.00 77.91  ? -7  A   B N9    1 
ATOM 5615 C C8    . A   B 2 30  ? 144.621 100.520 128.919 1.00 77.83  ? -7  A   B C8    1 
ATOM 5616 N N7    . A   B 2 30  ? 143.777 101.026 129.783 1.00 78.17  ? -7  A   B N7    1 
ATOM 5617 C C5    . A   B 2 30  ? 143.275 102.140 129.131 1.00 79.43  ? -7  A   B C5    1 
ATOM 5618 C C6    . A   B 2 30  ? 142.330 103.104 129.516 1.00 78.38  ? -7  A   B C6    1 
ATOM 5619 N N6    . A   B 2 30  ? 141.712 103.102 130.698 1.00 77.71  ? -7  A   B N6    1 
ATOM 5620 N N1    . A   B 2 30  ? 142.044 104.086 128.638 1.00 79.13  ? -7  A   B N1    1 
ATOM 5621 C C2    . A   B 2 30  ? 142.666 104.084 127.454 1.00 82.11  ? -7  A   B C2    1 
ATOM 5622 N N3    . A   B 2 30  ? 143.570 103.232 126.975 1.00 81.45  ? -7  A   B N3    1 
ATOM 5623 C C4    . A   B 2 30  ? 143.832 102.268 127.872 1.00 78.57  ? -7  A   B C4    1 
ATOM 5624 P P     . C   B 2 31  ? 149.864 103.018 126.343 1.00 90.15  ? -6  C   B P     1 
ATOM 5625 O OP1   . C   B 2 31  ? 150.926 103.206 125.321 1.00 82.19  ? -6  C   B OP1   1 
ATOM 5626 O OP2   . C   B 2 31  ? 150.237 102.872 127.773 1.00 77.04  ? -6  C   B OP2   1 
ATOM 5627 O "O5'" . C   B 2 31  ? 148.834 104.228 126.223 1.00 88.04  ? -6  C   B "O5'" 1 
ATOM 5628 C "C5'" . C   B 2 31  ? 148.626 104.908 124.993 1.00 79.51  ? -6  C   B "C5'" 1 
ATOM 5629 C "C4'" . C   B 2 31  ? 147.870 106.192 125.219 1.00 74.56  ? -6  C   B "C4'" 1 
ATOM 5630 O "O4'" . C   B 2 31  ? 146.540 105.875 125.693 1.00 70.27  ? -6  C   B "O4'" 1 
ATOM 5631 C "C3'" . C   B 2 31  ? 148.456 107.105 126.287 1.00 80.27  ? -6  C   B "C3'" 1 
ATOM 5632 O "O3'" . C   B 2 31  ? 149.420 107.996 125.756 1.00 80.13  ? -6  C   B "O3'" 1 
ATOM 5633 C "C2'" . C   B 2 31  ? 147.240 107.829 126.853 1.00 78.86  ? -6  C   B "C2'" 1 
ATOM 5634 O "O2'" . C   B 2 31  ? 146.907 108.948 126.046 1.00 78.93  ? -6  C   B "O2'" 1 
ATOM 5635 C "C1'" . C   B 2 31  ? 146.141 106.783 126.692 1.00 74.67  ? -6  C   B "C1'" 1 
ATOM 5636 N N1    . C   B 2 31  ? 145.840 106.007 127.916 1.00 79.24  ? -6  C   B N1    1 
ATOM 5637 C C2    . C   B 2 31  ? 144.766 106.401 128.716 1.00 81.34  ? -6  C   B C2    1 
ATOM 5638 O O2    . C   B 2 31  ? 144.130 107.418 128.404 1.00 80.83  ? -6  C   B O2    1 
ATOM 5639 N N3    . C   B 2 31  ? 144.455 105.670 129.811 1.00 80.63  ? -6  C   B N3    1 
ATOM 5640 C C4    . C   B 2 31  ? 145.163 104.580 130.109 1.00 78.18  ? -6  C   B C4    1 
ATOM 5641 N N4    . C   B 2 31  ? 144.820 103.890 131.200 1.00 76.15  ? -6  C   B N4    1 
ATOM 5642 C C5    . C   B 2 31  ? 146.251 104.144 129.303 1.00 79.85  ? -6  C   B C5    1 
ATOM 5643 C C6    . C   B 2 31  ? 146.544 104.877 128.223 1.00 78.59  ? -6  C   B C6    1 
ATOM 5644 P P     . U   B 2 32  ? 150.955 107.556 125.598 1.00 79.65  ? -5  U   B P     1 
ATOM 5645 O OP1   . U   B 2 32  ? 151.095 106.818 124.317 1.00 71.05  ? -5  U   B OP1   1 
ATOM 5646 O OP2   . U   B 2 32  ? 151.387 106.928 126.870 1.00 74.79  ? -5  U   B OP2   1 
ATOM 5647 O "O5'" . U   B 2 32  ? 151.723 108.942 125.437 1.00 73.31  ? -5  U   B "O5'" 1 
ATOM 5648 C "C5'" . U   B 2 32  ? 151.920 109.803 126.555 1.00 75.98  ? -5  U   B "C5'" 1 
ATOM 5649 C "C4'" . U   B 2 32  ? 150.871 110.886 126.628 1.00 73.95  ? -5  U   B "C4'" 1 
ATOM 5650 O "O4'" . U   B 2 32  ? 149.636 110.323 127.150 1.00 67.69  ? -5  U   B "O4'" 1 
ATOM 5651 C "C3'" . U   B 2 32  ? 151.220 112.057 127.544 1.00 71.35  ? -5  U   B "C3'" 1 
ATOM 5652 O "O3'" . U   B 2 32  ? 150.645 113.250 127.023 1.00 67.06  ? -5  U   B "O3'" 1 
ATOM 5653 C "C2'" . U   B 2 32  ? 150.515 111.689 128.843 1.00 73.46  ? -5  U   B "C2'" 1 
ATOM 5654 O "O2'" . U   B 2 32  ? 150.217 112.785 129.679 1.00 73.72  ? -5  U   B "O2'" 1 
ATOM 5655 C "C1'" . U   B 2 32  ? 149.251 111.016 128.321 1.00 68.08  ? -5  U   B "C1'" 1 
ATOM 5656 N N1    . U   B 2 32  ? 148.670 110.047 129.261 1.00 72.89  ? -5  U   B N1    1 
ATOM 5657 C C2    . U   B 2 32  ? 147.500 110.399 129.901 1.00 73.67  ? -5  U   B C2    1 
ATOM 5658 O O2    . U   B 2 32  ? 146.942 111.464 129.714 1.00 71.94  ? -5  U   B O2    1 
ATOM 5659 N N3    . U   B 2 32  ? 147.011 109.457 130.770 1.00 74.29  ? -5  U   B N3    1 
ATOM 5660 C C4    . U   B 2 32  ? 147.561 108.225 131.056 1.00 72.99  ? -5  U   B C4    1 
ATOM 5661 O O4    . U   B 2 32  ? 147.001 107.483 131.863 1.00 73.87  ? -5  U   B O4    1 
ATOM 5662 C C5    . U   B 2 32  ? 148.772 107.937 130.353 1.00 74.68  ? -5  U   B C5    1 
ATOM 5663 C C6    . U   B 2 32  ? 149.274 108.837 129.502 1.00 74.91  ? -5  U   B C6    1 
ATOM 5664 P P     . G   B 2 33  ? 151.523 114.241 126.117 1.00 74.59  ? -4  G   B P     1 
ATOM 5665 O OP1   . G   B 2 33  ? 152.607 113.457 125.474 1.00 62.35  ? -4  G   B OP1   1 
ATOM 5666 O OP2   . G   B 2 33  ? 151.870 115.425 126.944 1.00 59.84  ? -4  G   B OP2   1 
ATOM 5667 O "O5'" . G   B 2 33  ? 150.503 114.708 124.988 1.00 58.00  ? -4  G   B "O5'" 1 
ATOM 5668 C "C5'" . G   B 2 33  ? 149.183 115.096 125.330 1.00 49.77  ? -4  G   B "C5'" 1 
ATOM 5669 C "C4'" . G   B 2 33  ? 148.213 114.807 124.214 1.00 45.10  ? -4  G   B "C4'" 1 
ATOM 5670 O "O4'" . G   B 2 33  ? 147.492 113.579 124.493 1.00 53.63  ? -4  G   B "O4'" 1 
ATOM 5671 C "C3'" . G   B 2 33  ? 147.118 115.840 124.014 1.00 45.92  ? -4  G   B "C3'" 1 
ATOM 5672 O "O3'" . G   B 2 33  ? 147.558 116.957 123.261 1.00 48.93  ? -4  G   B "O3'" 1 
ATOM 5673 C "C2'" . G   B 2 33  ? 146.023 115.038 123.329 1.00 49.00  ? -4  G   B "C2'" 1 
ATOM 5674 O "O2'" . G   B 2 33  ? 146.308 114.886 121.946 1.00 58.94  ? -4  G   B "O2'" 1 
ATOM 5675 C "C1'" . G   B 2 33  ? 146.171 113.673 124.003 1.00 43.95  ? -4  G   B "C1'" 1 
ATOM 5676 N N9    . G   B 2 33  ? 145.234 113.472 125.130 1.00 34.43  ? -4  G   B N9    1 
ATOM 5677 C C8    . G   B 2 33  ? 145.561 112.926 126.346 1.00 42.95  ? -4  G   B C8    1 
ATOM 5678 N N7    . G   B 2 33  ? 144.554 112.842 127.168 1.00 43.07  ? -4  G   B N7    1 
ATOM 5679 C C5    . G   B 2 33  ? 143.484 113.354 126.452 1.00 41.47  ? -4  G   B C5    1 
ATOM 5680 C C6    . G   B 2 33  ? 142.126 113.517 126.829 1.00 43.20  ? -4  G   B C6    1 
ATOM 5681 O O6    . G   B 2 33  ? 141.564 113.237 127.894 1.00 45.47  ? -4  G   B O6    1 
ATOM 5682 N N1    . G   B 2 33  ? 141.375 114.074 125.806 1.00 39.06  ? -4  G   B N1    1 
ATOM 5683 C C2    . G   B 2 33  ? 141.865 114.431 124.581 1.00 42.16  ? -4  G   B C2    1 
ATOM 5684 N N2    . G   B 2 33  ? 140.993 114.958 123.715 1.00 46.39  ? -4  G   B N2    1 
ATOM 5685 N N3    . G   B 2 33  ? 143.125 114.284 124.218 1.00 39.88  ? -4  G   B N3    1 
ATOM 5686 C C4    . G   B 2 33  ? 143.883 113.743 125.191 1.00 38.43  ? -4  G   B C4    1 
ATOM 5687 P P     . C   B 2 34  ? 147.692 118.400 123.953 1.00 57.61  ? -3  C   B P     1 
ATOM 5688 O OP1   . C   B 2 34  ? 148.748 119.156 123.235 1.00 38.38  ? -3  C   B OP1   1 
ATOM 5689 O OP2   . C   B 2 34  ? 147.798 118.206 125.419 1.00 49.62  ? -3  C   B OP2   1 
ATOM 5690 O "O5'" . C   B 2 34  ? 146.296 119.102 123.646 1.00 38.70  ? -3  C   B "O5'" 1 
ATOM 5691 C "C5'" . C   B 2 34  ? 145.929 119.433 122.317 1.00 29.70  ? -3  C   B "C5'" 1 
ATOM 5692 C "C4'" . C   B 2 34  ? 144.442 119.620 122.180 1.00 29.03  ? -3  C   B "C4'" 1 
ATOM 5693 O "O4'" . C   B 2 34  ? 143.753 118.422 122.617 1.00 29.43  ? -3  C   B "O4'" 1 
ATOM 5694 C "C3'" . C   B 2 34  ? 143.823 120.720 123.022 1.00 37.15  ? -3  C   B "C3'" 1 
ATOM 5695 O "O3'" . C   B 2 34  ? 143.999 122.011 122.469 1.00 40.19  ? -3  C   B "O3'" 1 
ATOM 5696 C "C2'" . C   B 2 34  ? 142.368 120.286 123.107 1.00 36.14  ? -3  C   B "C2'" 1 
ATOM 5697 O "O2'" . C   B 2 34  ? 141.682 120.594 121.905 1.00 38.92  ? -3  C   B "O2'" 1 
ATOM 5698 C "C1'" . C   B 2 34  ? 142.513 118.768 123.197 1.00 26.95  ? -3  C   B "C1'" 1 
ATOM 5699 N N1    . C   B 2 34  ? 142.487 118.290 124.597 1.00 27.69  ? -3  C   B N1    1 
ATOM 5700 C C2    . C   B 2 34  ? 141.249 118.164 125.219 1.00 35.15  ? -3  C   B C2    1 
ATOM 5701 O O2    . C   B 2 34  ? 140.234 118.458 124.574 1.00 40.10  ? -3  C   B O2    1 
ATOM 5702 N N3    . C   B 2 34  ? 141.194 117.728 126.495 1.00 37.67  ? -3  C   B N3    1 
ATOM 5703 C C4    . C   B 2 34  ? 142.317 117.424 127.143 1.00 39.98  ? -3  C   B C4    1 
ATOM 5704 N N4    . C   B 2 34  ? 142.213 116.997 128.403 1.00 33.99  ? -3  C   B N4    1 
ATOM 5705 C C5    . C   B 2 34  ? 143.596 117.543 126.533 1.00 37.92  ? -3  C   B C5    1 
ATOM 5706 C C6    . C   B 2 34  ? 143.633 117.976 125.268 1.00 29.07  ? -3  C   B C6    1 
ATOM 5707 P P     . A   B 2 35  ? 144.239 123.270 123.435 1.00 46.48  ? -2  A   B P     1 
ATOM 5708 O OP1   . A   B 2 35  ? 144.642 124.415 122.583 1.00 45.93  ? -2  A   B OP1   1 
ATOM 5709 O OP2   . A   B 2 35  ? 145.128 122.841 124.542 1.00 41.31  ? -2  A   B OP2   1 
ATOM 5710 O "O5'" . A   B 2 35  ? 142.801 123.576 124.041 1.00 30.54  ? -2  A   B "O5'" 1 
ATOM 5711 C "C5'" . A   B 2 35  ? 141.818 124.234 123.262 1.00 29.96  ? -2  A   B "C5'" 1 
ATOM 5712 C "C4'" . A   B 2 35  ? 140.426 124.020 123.802 1.00 31.35  ? -2  A   B "C4'" 1 
ATOM 5713 O "O4'" . A   B 2 35  ? 140.230 122.623 124.129 1.00 37.59  ? -2  A   B "O4'" 1 
ATOM 5714 C "C3'" . A   B 2 35  ? 140.075 124.741 125.090 1.00 31.59  ? -2  A   B "C3'" 1 
ATOM 5715 O "O3'" . A   B 2 35  ? 139.759 126.108 124.898 1.00 42.74  ? -2  A   B "O3'" 1 
ATOM 5716 C "C2'" . A   B 2 35  ? 138.907 123.917 125.608 1.00 41.86  ? -2  A   B "C2'" 1 
ATOM 5717 O "O2'" . A   B 2 35  ? 137.725 124.221 124.883 1.00 39.17  ? -2  A   B "O2'" 1 
ATOM 5718 C "C1'" . A   B 2 35  ? 139.345 122.509 125.225 1.00 31.66  ? -2  A   B "C1'" 1 
ATOM 5719 N N9    . A   B 2 35  ? 140.037 121.822 126.329 1.00 29.35  ? -2  A   B N9    1 
ATOM 5720 C C8    . A   B 2 35  ? 141.384 121.682 126.530 1.00 37.04  ? -2  A   B C8    1 
ATOM 5721 N N7    . A   B 2 35  ? 141.689 121.006 127.609 1.00 31.84  ? -2  A   B N7    1 
ATOM 5722 C C5    . A   B 2 35  ? 140.456 120.681 128.153 1.00 37.93  ? -2  A   B C5    1 
ATOM 5723 C C6    . A   B 2 35  ? 140.088 119.967 129.305 1.00 44.95  ? -2  A   B C6    1 
ATOM 5724 N N6    . A   B 2 35  ? 140.967 119.429 130.152 1.00 49.61  ? -2  A   B N6    1 
ATOM 5725 N N1    . A   B 2 35  ? 138.771 119.825 129.561 1.00 39.85  ? -2  A   B N1    1 
ATOM 5726 C C2    . A   B 2 35  ? 137.892 120.369 128.713 1.00 42.65  ? -2  A   B C2    1 
ATOM 5727 N N3    . A   B 2 35  ? 138.115 121.057 127.598 1.00 27.68  ? -2  A   B N3    1 
ATOM 5728 C C4    . A   B 2 35  ? 139.432 121.178 127.375 1.00 29.71  ? -2  A   B C4    1 
ATOM 5729 P P     . C   B 2 36  ? 139.921 127.151 126.111 1.00 55.26  ? -1  C   B P     1 
ATOM 5730 O OP1   . C   B 2 36  ? 139.651 128.514 125.595 1.00 51.40  ? -1  C   B OP1   1 
ATOM 5731 O OP2   . C   B 2 36  ? 141.198 126.865 126.800 1.00 43.31  ? -1  C   B OP2   1 
ATOM 5732 O "O5'" . C   B 2 36  ? 138.743 126.769 127.107 1.00 33.01  ? -1  C   B "O5'" 1 
ATOM 5733 C "C5'" . C   B 2 36  ? 137.389 126.887 126.704 1.00 36.45  ? -1  C   B "C5'" 1 
ATOM 5734 C "C4'" . C   B 2 36  ? 136.457 126.282 127.720 1.00 32.99  ? -1  C   B "C4'" 1 
ATOM 5735 O "O4'" . C   B 2 36  ? 136.778 124.884 127.927 1.00 35.78  ? -1  C   B "O4'" 1 
ATOM 5736 C "C3'" . C   B 2 36  ? 136.525 126.872 129.115 1.00 47.51  ? -1  C   B "C3'" 1 
ATOM 5737 O "O3'" . C   B 2 36  ? 135.829 128.095 129.219 1.00 55.66  ? -1  C   B "O3'" 1 
ATOM 5738 C "C2'" . C   B 2 36  ? 135.937 125.758 129.968 1.00 43.36  ? -1  C   B "C2'" 1 
ATOM 5739 O "O2'" . C   B 2 36  ? 134.522 125.739 129.864 1.00 37.23  ? -1  C   B "O2'" 1 
ATOM 5740 C "C1'" . C   B 2 36  ? 136.485 124.520 129.259 1.00 32.21  ? -1  C   B "C1'" 1 
ATOM 5741 N N1    . C   B 2 36  ? 137.717 124.015 129.904 1.00 22.85  ? -1  C   B N1    1 
ATOM 5742 C C2    . C   B 2 36  ? 137.557 123.191 131.016 1.00 39.00  ? -1  C   B C2    1 
ATOM 5743 O O2    . C   B 2 36  ? 136.412 122.921 131.406 1.00 50.40  ? -1  C   B O2    1 
ATOM 5744 N N3    . C   B 2 36  ? 138.647 122.705 131.638 1.00 37.63  ? -1  C   B N3    1 
ATOM 5745 C C4    . C   B 2 36  ? 139.861 123.015 131.190 1.00 30.11  ? -1  C   B C4    1 
ATOM 5746 N N4    . C   B 2 36  ? 140.894 122.498 131.853 1.00 31.90  ? -1  C   B N4    1 
ATOM 5747 C C5    . C   B 2 36  ? 140.058 123.856 130.058 1.00 26.19  ? -1  C   B C5    1 
ATOM 5748 C C6    . C   B 2 36  ? 138.965 124.331 129.450 1.00 21.88  ? -1  C   B C6    1 
ATOM 5749 P P     . C   B 2 37  ? 136.443 129.309 130.066 1.00 62.01  ? 0   C   B P     1 
ATOM 5750 O OP1   . C   B 2 37  ? 137.562 129.908 129.302 1.00 54.36  ? 0   C   B OP1   1 
ATOM 5751 O OP2   . C   B 2 37  ? 136.678 128.828 131.450 1.00 40.08  ? 0   C   B OP2   1 
ATOM 5752 O "O5'" . C   B 2 37  ? 135.242 130.346 130.098 1.00 53.96  ? 0   C   B "O5'" 1 
ATOM 5753 C "C5'" . C   B 2 37  ? 133.907 129.871 130.101 1.00 50.81  ? 0   C   B "C5'" 1 
ATOM 5754 C "C4'" . C   B 2 37  ? 133.475 129.504 131.494 1.00 41.90  ? 0   C   B "C4'" 1 
ATOM 5755 O "O4'" . C   B 2 37  ? 133.320 130.707 132.271 1.00 62.82  ? 0   C   B "O4'" 1 
ATOM 5756 C "C3'" . C   B 2 37  ? 132.138 128.793 131.618 1.00 40.64  ? 0   C   B "C3'" 1 
ATOM 5757 O "O3'" . C   B 2 37  ? 132.290 127.392 131.442 1.00 52.60  ? 0   C   B "O3'" 1 
ATOM 5758 C "C2'" . C   B 2 37  ? 131.667 129.168 133.021 1.00 45.50  ? 0   C   B "C2'" 1 
ATOM 5759 O "O2'" . C   B 2 37  ? 132.192 128.263 133.980 1.00 62.92  ? 0   C   B "O2'" 1 
ATOM 5760 C "C1'" . C   B 2 37  ? 132.323 130.530 133.242 1.00 53.63  ? 0   C   B "C1'" 1 
ATOM 5761 N N1    . C   B 2 37  ? 131.395 131.682 133.208 1.00 45.49  ? 0   C   B N1    1 
ATOM 5762 C C2    . C   B 2 37  ? 130.993 132.150 134.448 1.00 47.44  ? 0   C   B C2    1 
ATOM 5763 O O2    . C   B 2 37  ? 131.418 131.541 135.436 1.00 57.56  ? 0   C   B O2    1 
ATOM 5764 N N3    . C   B 2 37  ? 130.178 133.218 134.540 1.00 47.75  ? 0   C   B N3    1 
ATOM 5765 C C4    . C   B 2 37  ? 129.771 133.820 133.425 1.00 46.11  ? 0   C   B C4    1 
ATOM 5766 N N4    . C   B 2 37  ? 128.961 134.872 133.559 1.00 42.37  ? 0   C   B N4    1 
ATOM 5767 C C5    . C   B 2 37  ? 130.177 133.371 132.134 1.00 53.30  ? 0   C   B C5    1 
ATOM 5768 C C6    . C   B 2 37  ? 130.993 132.310 132.066 1.00 51.41  ? 0   C   B C6    1 
ATOM 5769 P P     . U   B 2 38  ? 131.051 126.501 130.963 1.00 79.88  ? 1   U   B P     1 
ATOM 5770 O OP1   . U   B 2 38  ? 131.455 125.074 131.043 1.00 51.61  ? 1   U   B OP1   1 
ATOM 5771 O OP2   . U   B 2 38  ? 130.556 127.052 129.675 1.00 67.90  ? 1   U   B OP2   1 
ATOM 5772 O "O5'" . U   B 2 38  ? 129.958 126.773 132.089 1.00 64.22  ? 1   U   B "O5'" 1 
ATOM 5773 C "C5'" . U   B 2 38  ? 129.283 125.682 132.735 1.00 50.20  ? 1   U   B "C5'" 1 
ATOM 5774 C "C4'" . U   B 2 38  ? 129.819 125.476 134.131 1.00 51.65  ? 1   U   B "C4'" 1 
ATOM 5775 O "O4'" . U   B 2 38  ? 130.603 126.630 134.541 1.00 50.47  ? 1   U   B "O4'" 1 
ATOM 5776 C "C3'" . U   B 2 38  ? 128.759 125.331 135.211 1.00 55.86  ? 1   U   B "C3'" 1 
ATOM 5777 O "O3'" . U   B 2 38  ? 128.294 123.989 135.301 1.00 56.97  ? 1   U   B "O3'" 1 
ATOM 5778 C "C2'" . U   B 2 38  ? 129.506 125.798 136.451 1.00 56.11  ? 1   U   B "C2'" 1 
ATOM 5779 O "O2'" . U   B 2 38  ? 130.389 124.827 136.974 1.00 67.29  ? 1   U   B "O2'" 1 
ATOM 5780 C "C1'" . U   B 2 38  ? 130.284 126.978 135.880 1.00 50.64  ? 1   U   B "C1'" 1 
ATOM 5781 N N1    . U   B 2 38  ? 129.518 128.232 135.857 1.00 53.83  ? 1   U   B N1    1 
ATOM 5782 C C2    . U   B 2 38  ? 129.140 128.785 137.066 1.00 56.45  ? 1   U   B C2    1 
ATOM 5783 O O2    . U   B 2 38  ? 129.411 128.278 138.141 1.00 55.37  ? 1   U   B O2    1 
ATOM 5784 N N3    . U   B 2 38  ? 128.438 129.959 136.966 1.00 56.75  ? 1   U   B N3    1 
ATOM 5785 C C4    . U   B 2 38  ? 128.079 130.623 135.812 1.00 55.42  ? 1   U   B C4    1 
ATOM 5786 O O4    . U   B 2 38  ? 127.443 131.674 135.890 1.00 57.46  ? 1   U   B O4    1 
ATOM 5787 C C5    . U   B 2 38  ? 128.504 129.986 134.605 1.00 57.50  ? 1   U   B C5    1 
ATOM 5788 C C6    . U   B 2 38  ? 129.187 128.837 134.667 1.00 55.94  ? 1   U   B C6    1 
ATOM 5789 P P     . U   B 2 39  ? 126.744 123.659 135.059 1.00 49.92  ? 2   U   B P     1 
ATOM 5790 O OP1   . U   B 2 39  ? 126.563 122.190 135.182 1.00 56.16  ? 2   U   B OP1   1 
ATOM 5791 O OP2   . U   B 2 39  ? 126.309 124.351 133.819 1.00 46.90  ? 2   U   B OP2   1 
ATOM 5792 O "O5'" . U   B 2 39  ? 126.032 124.350 136.305 1.00 53.91  ? 2   U   B "O5'" 1 
ATOM 5793 C "C5'" . U   B 2 39  ? 126.752 124.558 137.533 1.00 49.55  ? 2   U   B "C5'" 1 
ATOM 5794 C "C4'" . U   B 2 39  ? 126.017 125.537 138.409 1.00 48.69  ? 2   U   B "C4'" 1 
ATOM 5795 O "O4'" . U   B 2 39  ? 126.375 126.893 138.057 1.00 44.26  ? 2   U   B "O4'" 1 
ATOM 5796 C "C3'" . U   B 2 39  ? 124.508 125.526 138.267 1.00 54.47  ? 2   U   B "C3'" 1 
ATOM 5797 O "O3'" . U   B 2 39  ? 124.012 124.457 139.058 1.00 51.11  ? 2   U   B "O3'" 1 
ATOM 5798 C "C2'" . U   B 2 39  ? 124.118 126.893 138.824 1.00 53.02  ? 2   U   B "C2'" 1 
ATOM 5799 O "O2'" . U   B 2 39  ? 123.941 126.898 140.226 1.00 54.01  ? 2   U   B "O2'" 1 
ATOM 5800 C "C1'" . U   B 2 39  ? 125.319 127.761 138.429 1.00 43.81  ? 2   U   B "C1'" 1 
ATOM 5801 N N1    . U   B 2 39  ? 125.040 128.662 137.303 1.00 40.30  ? 2   U   B N1    1 
ATOM 5802 C C2    . U   B 2 39  ? 124.257 129.773 137.549 1.00 52.61  ? 2   U   B C2    1 
ATOM 5803 O O2    . U   B 2 39  ? 123.799 130.030 138.649 1.00 53.73  ? 2   U   B O2    1 
ATOM 5804 N N3    . U   B 2 39  ? 124.035 130.573 136.457 1.00 53.09  ? 2   U   B N3    1 
ATOM 5805 C C4    . U   B 2 39  ? 124.502 130.386 135.174 1.00 48.41  ? 2   U   B C4    1 
ATOM 5806 O O4    . U   B 2 39  ? 124.211 131.201 134.297 1.00 52.39  ? 2   U   B O4    1 
ATOM 5807 C C5    . U   B 2 39  ? 125.301 129.212 134.999 1.00 43.06  ? 2   U   B C5    1 
ATOM 5808 C C6    . U   B 2 39  ? 125.538 128.410 136.044 1.00 41.57  ? 2   U   B C6    1 
ATOM 5809 P P     . C   B 2 40  ? 122.825 123.527 138.508 1.00 57.25  ? 3   C   B P     1 
ATOM 5810 O OP1   . C   B 2 40  ? 121.938 123.192 139.651 1.00 54.30  ? 3   C   B OP1   1 
ATOM 5811 O OP2   . C   B 2 40  ? 123.432 122.436 137.704 1.00 51.94  ? 3   C   B OP2   1 
ATOM 5812 O "O5'" . C   B 2 40  ? 122.023 124.490 137.523 1.00 52.16  ? 3   C   B "O5'" 1 
ATOM 5813 C "C5'" . C   B 2 40  ? 120.591 124.614 137.607 1.00 46.70  ? 3   C   B "C5'" 1 
ATOM 5814 C "C4'" . C   B 2 40  ? 120.218 125.802 138.461 1.00 53.13  ? 3   C   B "C4'" 1 
ATOM 5815 O "O4'" . C   B 2 40  ? 121.202 126.852 138.279 1.00 51.08  ? 3   C   B "O4'" 1 
ATOM 5816 C "C3'" . C   B 2 40  ? 118.881 126.448 138.136 1.00 55.06  ? 3   C   B "C3'" 1 
ATOM 5817 O "O3'" . C   B 2 40  ? 117.863 125.864 138.932 1.00 58.57  ? 3   C   B "O3'" 1 
ATOM 5818 C "C2'" . C   B 2 40  ? 119.083 127.885 138.599 1.00 49.18  ? 3   C   B "C2'" 1 
ATOM 5819 O "O2'" . C   B 2 40  ? 118.829 128.073 139.976 1.00 54.04  ? 3   C   B "O2'" 1 
ATOM 5820 C "C1'" . C   B 2 40  ? 120.564 128.116 138.294 1.00 47.90  ? 3   C   B "C1'" 1 
ATOM 5821 N N1    . C   B 2 40  ? 120.802 128.765 136.996 1.00 46.83  ? 3   C   B N1    1 
ATOM 5822 C C2    . C   B 2 40  ? 120.228 130.014 136.748 1.00 51.06  ? 3   C   B C2    1 
ATOM 5823 O O2    . C   B 2 40  ? 119.530 130.539 137.628 1.00 46.85  ? 3   C   B O2    1 
ATOM 5824 N N3    . C   B 2 40  ? 120.447 130.618 135.558 1.00 54.51  ? 3   C   B N3    1 
ATOM 5825 C C4    . C   B 2 40  ? 121.205 130.019 134.636 1.00 49.41  ? 3   C   B C4    1 
ATOM 5826 N N4    . C   B 2 40  ? 121.393 130.651 133.475 1.00 51.65  ? 3   C   B N4    1 
ATOM 5827 C C5    . C   B 2 40  ? 121.802 128.746 134.863 1.00 46.49  ? 3   C   B C5    1 
ATOM 5828 C C6    . C   B 2 40  ? 121.579 128.162 136.047 1.00 49.51  ? 3   C   B C6    1 
ATOM 5829 P P     . DA  C 3 32  ? 116.485 140.699 137.456 1.00 66.40  ? -2  DA  C P     1 
ATOM 5830 O OP1   . DA  C 3 32  ? 116.007 141.891 138.188 1.00 61.10  ? -2  DA  C OP1   1 
ATOM 5831 O OP2   . DA  C 3 32  ? 117.453 140.848 136.349 1.00 61.58  ? -2  DA  C OP2   1 
ATOM 5832 O "O5'" . DA  C 3 32  ? 117.103 139.662 138.507 1.00 60.20  ? -2  DA  C "O5'" 1 
ATOM 5833 C "C5'" . DA  C 3 32  ? 116.400 139.359 139.705 1.00 55.27  ? -2  DA  C "C5'" 1 
ATOM 5834 C "C4'" . DA  C 3 32  ? 117.098 138.258 140.488 1.00 55.64  ? -2  DA  C "C4'" 1 
ATOM 5835 O "O4'" . DA  C 3 32  ? 117.067 137.029 139.734 1.00 56.54  ? -2  DA  C "O4'" 1 
ATOM 5836 C "C3'" . DA  C 3 32  ? 118.568 138.491 140.758 1.00 52.22  ? -2  DA  C "C3'" 1 
ATOM 5837 O "O3'" . DA  C 3 32  ? 118.727 139.301 141.908 1.00 55.79  ? -2  DA  C "O3'" 1 
ATOM 5838 C "C2'" . DA  C 3 32  ? 119.075 137.073 141.004 1.00 53.84  ? -2  DA  C "C2'" 1 
ATOM 5839 C "C1'" . DA  C 3 32  ? 118.181 136.231 140.095 1.00 51.10  ? -2  DA  C "C1'" 1 
ATOM 5840 N N9    . DA  C 3 32  ? 118.839 135.775 138.878 1.00 44.94  ? -2  DA  C N9    1 
ATOM 5841 C C8    . DA  C 3 32  ? 118.762 136.342 137.640 1.00 51.75  ? -2  DA  C C8    1 
ATOM 5842 N N7    . DA  C 3 32  ? 119.452 135.709 136.723 1.00 55.38  ? -2  DA  C N7    1 
ATOM 5843 C C5    . DA  C 3 32  ? 120.020 134.649 137.410 1.00 50.55  ? -2  DA  C C5    1 
ATOM 5844 C C6    . DA  C 3 32  ? 120.867 133.602 137.002 1.00 46.31  ? -2  DA  C C6    1 
ATOM 5845 N N6    . DA  C 3 32  ? 121.302 133.452 135.751 1.00 48.01  ? -2  DA  C N6    1 
ATOM 5846 N N1    . DA  C 3 32  ? 121.250 132.710 137.935 1.00 43.85  ? -2  DA  C N1    1 
ATOM 5847 C C2    . DA  C 3 32  ? 120.811 132.863 139.190 1.00 50.60  ? -2  DA  C C2    1 
ATOM 5848 N N3    . DA  C 3 32  ? 120.013 133.804 139.690 1.00 52.12  ? -2  DA  C N3    1 
ATOM 5849 C C4    . DA  C 3 32  ? 119.651 134.675 138.738 1.00 46.77  ? -2  DA  C C4    1 
ATOM 5850 P P     . DA  C 3 33  ? 120.129 140.029 142.194 1.00 65.46  ? -1  DA  C P     1 
ATOM 5851 O OP1   . DA  C 3 33  ? 119.942 140.927 143.352 1.00 51.41  ? -1  DA  C OP1   1 
ATOM 5852 O OP2   . DA  C 3 33  ? 120.620 140.571 140.909 1.00 46.55  ? -1  DA  C OP2   1 
ATOM 5853 O "O5'" . DA  C 3 33  ? 121.094 138.840 142.649 1.00 43.52  ? -1  DA  C "O5'" 1 
ATOM 5854 C "C5'" . DA  C 3 33  ? 122.159 138.432 141.804 1.00 38.78  ? -1  DA  C "C5'" 1 
ATOM 5855 C "C4'" . DA  C 3 33  ? 122.898 137.251 142.400 1.00 38.87  ? -1  DA  C "C4'" 1 
ATOM 5856 O "O4'" . DA  C 3 33  ? 122.515 136.040 141.706 1.00 30.21  ? -1  DA  C "O4'" 1 
ATOM 5857 C "C3'" . DA  C 3 33  ? 124.408 137.336 142.288 1.00 38.97  ? -1  DA  C "C3'" 1 
ATOM 5858 O "O3'" . DA  C 3 33  ? 124.932 137.920 143.463 1.00 39.32  ? -1  DA  C "O3'" 1 
ATOM 5859 C "C2'" . DA  C 3 33  ? 124.827 135.878 142.153 1.00 39.87  ? -1  DA  C "C2'" 1 
ATOM 5860 C "C1'" . DA  C 3 33  ? 123.660 135.278 141.381 1.00 34.10  ? -1  DA  C "C1'" 1 
ATOM 5861 N N9    . DA  C 3 33  ? 123.820 135.299 139.931 1.00 37.88  ? -1  DA  C N9    1 
ATOM 5862 C C8    . DA  C 3 33  ? 123.298 136.215 139.064 1.00 43.88  ? -1  DA  C C8    1 
ATOM 5863 N N7    . DA  C 3 33  ? 123.585 135.979 137.808 1.00 45.81  ? -1  DA  C N7    1 
ATOM 5864 C C5    . DA  C 3 33  ? 124.342 134.822 137.852 1.00 40.34  ? -1  DA  C C5    1 
ATOM 5865 C C6    . DA  C 3 33  ? 124.954 134.055 136.845 1.00 35.76  ? -1  DA  C C6    1 
ATOM 5866 N N6    . DA  C 3 33  ? 124.887 134.360 135.548 1.00 36.36  ? -1  DA  C N6    1 
ATOM 5867 N N1    . DA  C 3 33  ? 125.637 132.957 137.224 1.00 34.24  ? -1  DA  C N1    1 
ATOM 5868 C C2    . DA  C 3 33  ? 125.699 132.654 138.524 1.00 35.66  ? -1  DA  C C2    1 
ATOM 5869 N N3    . DA  C 3 33  ? 125.165 133.300 139.561 1.00 38.18  ? -1  DA  C N3    1 
ATOM 5870 C C4    . DA  C 3 33  ? 124.493 134.384 139.152 1.00 39.50  ? -1  DA  C C4    1 
ATOM 5871 P P     . DG  C 3 34  ? 126.154 138.955 143.372 1.00 59.86  ? 0   DG  C P     1 
ATOM 5872 O OP1   . DG  C 3 34  ? 126.129 139.778 144.599 1.00 54.20  ? 0   DG  C OP1   1 
ATOM 5873 O OP2   . DG  C 3 34  ? 126.102 139.601 142.042 1.00 43.61  ? 0   DG  C OP2   1 
ATOM 5874 O "O5'" . DG  C 3 34  ? 127.442 138.015 143.406 1.00 45.49  ? 0   DG  C "O5'" 1 
ATOM 5875 C "C5'" . DG  C 3 34  ? 127.623 137.117 144.480 1.00 34.47  ? 0   DG  C "C5'" 1 
ATOM 5876 C "C4'" . DG  C 3 34  ? 128.561 135.996 144.088 1.00 38.96  ? 0   DG  C "C4'" 1 
ATOM 5877 O "O4'" . DG  C 3 34  ? 127.921 135.152 143.101 1.00 46.53  ? 0   DG  C "O4'" 1 
ATOM 5878 C "C3'" . DG  C 3 34  ? 129.848 136.444 143.432 1.00 33.92  ? 0   DG  C "C3'" 1 
ATOM 5879 O "O3'" . DG  C 3 34  ? 130.810 136.795 144.431 1.00 43.40  ? 0   DG  C "O3'" 1 
ATOM 5880 C "C2'" . DG  C 3 34  ? 130.249 135.186 142.666 1.00 33.27  ? 0   DG  C "C2'" 1 
ATOM 5881 C "C1'" . DG  C 3 34  ? 128.890 134.665 142.190 1.00 39.75  ? 0   DG  C "C1'" 1 
ATOM 5882 N N9    . DG  C 3 34  ? 128.531 135.117 140.848 1.00 35.33  ? 0   DG  C N9    1 
ATOM 5883 C C8    . DG  C 3 34  ? 127.797 136.229 140.522 1.00 44.90  ? 0   DG  C C8    1 
ATOM 5884 N N7    . DG  C 3 34  ? 127.640 136.391 139.239 1.00 45.43  ? 0   DG  C N7    1 
ATOM 5885 C C5    . DG  C 3 34  ? 128.312 135.318 138.676 1.00 44.70  ? 0   DG  C C5    1 
ATOM 5886 C C6    . DG  C 3 34  ? 128.487 134.963 137.318 1.00 50.05  ? 0   DG  C C6    1 
ATOM 5887 O O6    . DG  C 3 34  ? 128.065 135.546 136.309 1.00 51.03  ? 0   DG  C O6    1 
ATOM 5888 N N1    . DG  C 3 34  ? 129.236 133.800 137.185 1.00 40.94  ? 0   DG  C N1    1 
ATOM 5889 C C2    . DG  C 3 34  ? 129.754 133.075 138.228 1.00 35.30  ? 0   DG  C C2    1 
ATOM 5890 N N2    . DG  C 3 34  ? 130.448 131.982 137.905 1.00 33.69  ? 0   DG  C N2    1 
ATOM 5891 N N3    . DG  C 3 34  ? 129.596 133.396 139.504 1.00 45.92  ? 0   DG  C N3    1 
ATOM 5892 C C4    . DG  C 3 34  ? 128.868 134.525 139.652 1.00 41.00  ? 0   DG  C C4    1 
ATOM 5893 P P     . DC  C 3 35  ? 131.569 138.205 144.353 1.00 49.44  ? 1   DC  C P     1 
ATOM 5894 O OP1   . DC  C 3 35  ? 130.555 139.262 144.103 1.00 51.15  ? 1   DC  C OP1   1 
ATOM 5895 O OP2   . DC  C 3 35  ? 132.718 138.057 143.423 1.00 51.87  ? 1   DC  C OP2   1 
ATOM 5896 O "O5'" . DC  C 3 35  ? 132.142 138.389 145.828 1.00 44.91  ? 1   DC  C "O5'" 1 
ATOM 5897 C "C5'" . DC  C 3 35  ? 131.401 139.112 146.830 1.00 42.61  ? 1   DC  C "C5'" 1 
ATOM 5898 C "C4'" . DC  C 3 35  ? 131.577 140.601 146.640 1.00 44.93  ? 1   DC  C "C4'" 1 
ATOM 5899 O "O4'" . DC  C 3 35  ? 130.430 141.296 147.186 1.00 47.64  ? 1   DC  C "O4'" 1 
ATOM 5900 C "C3'" . DC  C 3 35  ? 132.801 141.198 147.337 1.00 46.23  ? 1   DC  C "C3'" 1 
ATOM 5901 O "O3'" . DC  C 3 35  ? 133.374 142.231 146.528 1.00 60.43  ? 1   DC  C "O3'" 1 
ATOM 5902 C "C2'" . DC  C 3 35  ? 132.222 141.795 148.605 1.00 43.57  ? 1   DC  C "C2'" 1 
ATOM 5903 C "C1'" . DC  C 3 35  ? 130.866 142.273 148.119 1.00 44.49  ? 1   DC  C "C1'" 1 
ATOM 5904 N N1    . DC  C 3 35  ? 129.838 142.393 149.164 1.00 41.51  ? 1   DC  C N1    1 
ATOM 5905 C C2    . DC  C 3 35  ? 129.524 141.275 149.943 1.00 54.84  ? 1   DC  C C2    1 
ATOM 5906 O O2    . DC  C 3 35  ? 130.121 140.209 149.731 1.00 64.52  ? 1   DC  C O2    1 
ATOM 5907 N N3    . DC  C 3 35  ? 128.578 141.384 150.904 1.00 48.19  ? 1   DC  C N3    1 
ATOM 5908 C C4    . DC  C 3 35  ? 127.956 142.549 151.099 1.00 45.05  ? 1   DC  C C4    1 
ATOM 5909 N N4    . DC  C 3 35  ? 127.030 142.611 152.058 1.00 47.51  ? 1   DC  C N4    1 
ATOM 5910 C C5    . DC  C 3 35  ? 128.257 143.703 150.318 1.00 47.45  ? 1   DC  C C5    1 
ATOM 5911 C C6    . DC  C 3 35  ? 129.196 143.581 149.372 1.00 41.12  ? 1   DC  C C6    1 
ATOM 5912 P P     . DA  C 3 36  ? 134.792 142.884 146.917 1.00 69.72  ? 2   DA  C P     1 
ATOM 5913 O OP1   . DA  C 3 36  ? 135.686 142.762 145.749 1.00 61.51  ? 2   DA  C OP1   1 
ATOM 5914 O OP2   . DA  C 3 36  ? 135.216 142.347 148.226 1.00 64.34  ? 2   DA  C OP2   1 
ATOM 5915 O "O5'" . DA  C 3 36  ? 134.447 144.432 147.108 1.00 58.64  ? 2   DA  C "O5'" 1 
ATOM 5916 C "C5'" . DA  C 3 36  ? 133.428 144.827 148.015 1.00 61.29  ? 2   DA  C "C5'" 1 
ATOM 5917 C "C4'" . DA  C 3 36  ? 133.260 146.333 148.018 1.00 58.90  ? 2   DA  C "C4'" 1 
ATOM 5918 O "O4'" . DA  C 3 36  ? 131.998 146.674 148.645 1.00 58.60  ? 2   DA  C "O4'" 1 
ATOM 5919 C "C3'" . DA  C 3 36  ? 134.308 147.092 148.814 1.00 63.65  ? 2   DA  C "C3'" 1 
ATOM 5920 O "O3'" . DA  C 3 36  ? 134.402 148.421 148.320 1.00 67.61  ? 2   DA  C "O3'" 1 
ATOM 5921 C "C2'" . DA  C 3 36  ? 133.699 147.065 150.206 1.00 62.25  ? 2   DA  C "C2'" 1 
ATOM 5922 C "C1'" . DA  C 3 36  ? 132.245 147.349 149.865 1.00 64.58  ? 2   DA  C "C1'" 1 
ATOM 5923 N N9    . DA  C 3 36  ? 131.283 146.873 150.855 1.00 66.66  ? 2   DA  C N9    1 
ATOM 5924 C C8    . DA  C 3 36  ? 130.262 147.590 151.414 1.00 71.52  ? 2   DA  C C8    1 
ATOM 5925 N N7    . DA  C 3 36  ? 129.536 146.905 152.263 1.00 61.29  ? 2   DA  C N7    1 
ATOM 5926 C C5    . DA  C 3 36  ? 130.121 145.655 152.262 1.00 55.36  ? 2   DA  C C5    1 
ATOM 5927 C C6    . DA  C 3 36  ? 129.820 144.472 152.956 1.00 60.95  ? 2   DA  C C6    1 
ATOM 5928 N N6    . DA  C 3 36  ? 128.809 144.362 153.823 1.00 62.80  ? 2   DA  C N6    1 
ATOM 5929 N N1    . DA  C 3 36  ? 130.601 143.401 152.725 1.00 68.09  ? 2   DA  C N1    1 
ATOM 5930 C C2    . DA  C 3 36  ? 131.610 143.515 151.855 1.00 61.92  ? 2   DA  C C2    1 
ATOM 5931 N N3    . DA  C 3 36  ? 131.989 144.570 151.145 1.00 52.43  ? 2   DA  C N3    1 
ATOM 5932 C C4    . DA  C 3 36  ? 131.197 145.616 151.396 1.00 54.21  ? 2   DA  C C4    1 
ATOM 5933 P P     . DT  C 3 37  ? 135.797 149.215 148.356 1.00 80.73  ? 3   DT  C P     1 
ATOM 5934 O OP1   . DT  C 3 37  ? 136.036 149.755 147.002 1.00 71.43  ? 3   DT  C OP1   1 
ATOM 5935 O OP2   . DT  C 3 37  ? 136.807 148.336 148.986 1.00 73.63  ? 3   DT  C OP2   1 
ATOM 5936 O "O5'" . DT  C 3 37  ? 135.517 150.433 149.352 1.00 74.62  ? 3   DT  C "O5'" 1 
ATOM 5937 C "C5'" . DT  C 3 37  ? 135.271 150.181 150.728 1.00 72.55  ? 3   DT  C "C5'" 1 
ATOM 5938 C "C4'" . DT  C 3 37  ? 134.268 151.170 151.288 1.00 72.46  ? 3   DT  C "C4'" 1 
ATOM 5939 O "O4'" . DT  C 3 37  ? 133.148 150.449 151.855 1.00 70.73  ? 3   DT  C "O4'" 1 
ATOM 5940 C "C3'" . DT  C 3 37  ? 134.792 152.034 152.421 1.00 77.07  ? 3   DT  C "C3'" 1 
ATOM 5941 O "O3'" . DT  C 3 37  ? 134.047 153.239 152.490 1.00 76.37  ? 3   DT  C "O3'" 1 
ATOM 5942 C "C2'" . DT  C 3 37  ? 134.532 151.150 153.632 1.00 74.15  ? 3   DT  C "C2'" 1 
ATOM 5943 C "C1'" . DT  C 3 37  ? 133.187 150.531 153.269 1.00 71.78  ? 3   DT  C "C1'" 1 
ATOM 5944 N N1    . DT  C 3 37  ? 132.992 149.168 153.819 1.00 68.55  ? 3   DT  C N1    1 
ATOM 5945 C C2    . DT  C 3 37  ? 131.889 148.911 154.591 1.00 72.92  ? 3   DT  C C2    1 
ATOM 5946 O O2    . DT  C 3 37  ? 131.051 149.753 154.856 1.00 78.01  ? 3   DT  C O2    1 
ATOM 5947 N N3    . DT  C 3 37  ? 131.797 147.626 155.047 1.00 70.26  ? 3   DT  C N3    1 
ATOM 5948 C C4    . DT  C 3 37  ? 132.680 146.591 154.811 1.00 68.80  ? 3   DT  C C4    1 
ATOM 5949 O O4    . DT  C 3 37  ? 132.510 145.467 155.267 1.00 72.63  ? 3   DT  C O4    1 
ATOM 5950 C C5    . DT  C 3 37  ? 133.818 146.928 153.992 1.00 70.54  ? 3   DT  C C5    1 
ATOM 5951 C C7    . DT  C 3 37  ? 134.849 145.888 153.666 1.00 70.32  ? 3   DT  C C7    1 
ATOM 5952 C C6    . DT  C 3 37  ? 133.917 148.186 153.542 1.00 70.51  ? 3   DT  C C6    1 
ATOM 5953 P P     . DA  C 3 38  ? 134.648 154.516 153.254 1.00 97.34  ? 4   DA  C P     1 
ATOM 5954 O OP1   . DA  C 3 38  ? 134.100 155.727 152.608 1.00 94.68  ? 4   DA  C OP1   1 
ATOM 5955 O OP2   . DA  C 3 38  ? 136.113 154.328 153.352 1.00 93.57  ? 4   DA  C OP2   1 
ATOM 5956 O "O5'" . DA  C 3 38  ? 134.049 154.396 154.730 1.00 94.13  ? 4   DA  C "O5'" 1 
ATOM 5957 C "C5'" . DA  C 3 38  ? 132.645 154.510 154.946 1.00 92.86  ? 4   DA  C "C5'" 1 
ATOM 5958 C "C4'" . DA  C 3 38  ? 132.324 154.326 156.415 1.00 90.79  ? 4   DA  C "C4'" 1 
ATOM 5959 O "O4'" . DA  C 3 38  ? 132.021 152.945 156.664 1.00 88.77  ? 4   DA  C "O4'" 1 
ATOM 5960 C "C3'" . DA  C 3 38  ? 133.472 154.671 157.348 1.00 93.07  ? 4   DA  C "C3'" 1 
ATOM 5961 O "O3'" . DA  C 3 38  ? 133.309 155.994 157.841 1.00 94.38  ? 4   DA  C "O3'" 1 
ATOM 5962 C "C2'" . DA  C 3 38  ? 133.386 153.633 158.476 1.00 94.77  ? 4   DA  C "C2'" 1 
ATOM 5963 C "C1'" . DA  C 3 38  ? 132.349 152.618 157.993 1.00 90.67  ? 4   DA  C "C1'" 1 
ATOM 5964 N N9    . DA  C 3 38  ? 132.828 151.238 158.006 1.00 92.35  ? 4   DA  C N9    1 
ATOM 5965 C C8    . DA  C 3 38  ? 133.848 150.717 157.262 1.00 89.15  ? 4   DA  C C8    1 
ATOM 5966 N N7    . DA  C 3 38  ? 134.050 149.439 157.465 1.00 90.75  ? 4   DA  C N7    1 
ATOM 5967 C C5    . DA  C 3 38  ? 133.093 149.093 158.403 1.00 93.04  ? 4   DA  C C5    1 
ATOM 5968 C C6    . DA  C 3 38  ? 132.781 147.875 159.035 1.00 91.37  ? 4   DA  C C6    1 
ATOM 5969 N N6    . DA  C 3 38  ? 133.440 146.738 158.797 1.00 90.22  ? 4   DA  C N6    1 
ATOM 5970 N N1    . DA  C 3 38  ? 131.765 147.871 159.924 1.00 92.00  ? 4   DA  C N1    1 
ATOM 5971 C C2    . DA  C 3 38  ? 131.111 149.015 160.159 1.00 93.43  ? 4   DA  C C2    1 
ATOM 5972 N N3    . DA  C 3 38  ? 131.311 150.220 159.624 1.00 95.23  ? 4   DA  C N3    1 
ATOM 5973 C C4    . DA  C 3 38  ? 132.327 150.190 158.745 1.00 95.45  ? 4   DA  C C4    1 
ATOM 5974 P P     . DT  C 3 39  ? 134.428 156.650 158.788 1.00 109.66 ? 5   DT  C P     1 
ATOM 5975 O OP1   . DT  C 3 39  ? 134.310 158.120 158.671 1.00 108.98 ? 5   DT  C OP1   1 
ATOM 5976 O OP2   . DT  C 3 39  ? 135.715 155.987 158.487 1.00 108.26 ? 5   DT  C OP2   1 
ATOM 5977 O "O5'" . DT  C 3 39  ? 133.980 156.213 160.258 1.00 106.18 ? 5   DT  C "O5'" 1 
ATOM 5978 C "C5'" . DT  C 3 39  ? 132.621 156.338 160.643 1.00 105.88 ? 5   DT  C "C5'" 1 
ATOM 5979 C "C4'" . DT  C 3 39  ? 132.318 155.477 161.857 1.00 107.25 ? 5   DT  C "C4'" 1 
ATOM 5980 O "O4'" . DT  C 3 39  ? 132.506 154.076 161.532 1.00 103.71 ? 5   DT  C "O4'" 1 
ATOM 5981 C "C3'" . DT  C 3 39  ? 133.196 155.757 163.083 1.00 110.25 ? 5   DT  C "C3'" 1 
ATOM 5982 O "O3'" . DT  C 3 39  ? 132.377 156.061 164.209 1.00 112.51 ? 5   DT  C "O3'" 1 
ATOM 5983 C "C2'" . DT  C 3 39  ? 133.971 154.455 163.283 1.00 109.35 ? 5   DT  C "C2'" 1 
ATOM 5984 C "C1'" . DT  C 3 39  ? 133.050 153.428 162.652 1.00 104.62 ? 5   DT  C "C1'" 1 
ATOM 5985 N N1    . DT  C 3 39  ? 133.767 152.195 162.205 1.00 105.73 ? 5   DT  C N1    1 
ATOM 5986 C C2    . DT  C 3 39  ? 133.446 150.981 162.769 1.00 107.59 ? 5   DT  C C2    1 
ATOM 5987 O O2    . DT  C 3 39  ? 132.586 150.845 163.621 1.00 109.05 ? 5   DT  C O2    1 
ATOM 5988 N N3    . DT  C 3 39  ? 134.177 149.920 162.298 1.00 106.20 ? 5   DT  C N3    1 
ATOM 5989 C C4    . DT  C 3 39  ? 135.175 149.955 161.341 1.00 107.13 ? 5   DT  C C4    1 
ATOM 5990 O O4    . DT  C 3 39  ? 135.774 148.950 160.978 1.00 110.05 ? 5   DT  C O4    1 
ATOM 5991 C C5    . DT  C 3 39  ? 135.461 151.258 160.797 1.00 105.27 ? 5   DT  C C5    1 
ATOM 5992 C C7    . DT  C 3 39  ? 136.524 151.420 159.752 1.00 105.98 ? 5   DT  C C7    1 
ATOM 5993 C C6    . DT  C 3 39  ? 134.758 152.303 161.253 1.00 105.76 ? 5   DT  C C6    1 
ATOM 5994 P P     . DC  C 3 40  ? 133.039 156.506 165.606 1.00 125.16 ? 6   DC  C P     1 
ATOM 5995 O OP1   . DC  C 3 40  ? 132.282 157.681 166.093 1.00 121.39 ? 6   DC  C OP1   1 
ATOM 5996 O OP2   . DC  C 3 40  ? 134.504 156.615 165.428 1.00 119.24 ? 6   DC  C OP2   1 
ATOM 5997 O "O5'" . DC  C 3 40  ? 132.739 155.272 166.580 1.00 118.25 ? 6   DC  C "O5'" 1 
ATOM 5998 C "C5'" . DC  C 3 40  ? 131.391 154.891 166.839 1.00 116.31 ? 6   DC  C "C5'" 1 
ATOM 5999 C "C4'" . DC  C 3 40  ? 131.324 153.659 167.726 1.00 117.92 ? 6   DC  C "C4'" 1 
ATOM 6000 O "O4'" . DC  C 3 40  ? 131.867 152.511 167.021 1.00 119.02 ? 6   DC  C "O4'" 1 
ATOM 6001 C "C3'" . DC  C 3 40  ? 132.096 153.760 169.034 1.00 122.31 ? 6   DC  C "C3'" 1 
ATOM 6002 O "O3'" . DC  C 3 40  ? 131.369 153.125 170.074 1.00 123.18 ? 6   DC  C "O3'" 1 
ATOM 6003 C "C2'" . DC  C 3 40  ? 133.398 153.024 168.724 1.00 122.02 ? 6   DC  C "C2'" 1 
ATOM 6004 C "C1'" . DC  C 3 40  ? 132.928 151.941 167.762 1.00 120.03 ? 6   DC  C "C1'" 1 
ATOM 6005 N N1    . DC  C 3 40  ? 133.977 151.508 166.794 1.00 119.51 ? 6   DC  C N1    1 
ATOM 6006 C C2    . DC  C 3 40  ? 134.361 150.160 166.725 1.00 120.00 ? 6   DC  C C2    1 
ATOM 6007 O O2    . DC  C 3 40  ? 133.835 149.340 167.484 1.00 119.93 ? 6   DC  C O2    1 
ATOM 6008 N N3    . DC  C 3 40  ? 135.313 149.799 165.823 1.00 120.37 ? 6   DC  C N3    1 
ATOM 6009 C C4    . DC  C 3 40  ? 135.858 150.714 165.023 1.00 120.07 ? 6   DC  C C4    1 
ATOM 6010 N N4    . DC  C 3 40  ? 136.791 150.320 164.152 1.00 119.61 ? 6   DC  C N4    1 
ATOM 6011 C C5    . DC  C 3 40  ? 135.478 152.082 165.085 1.00 119.23 ? 6   DC  C C5    1 
ATOM 6012 C C6    . DC  C 3 40  ? 134.542 152.430 165.968 1.00 119.18 ? 6   DC  C C6    1 
ATOM 6013 P P     . DG  C 3 41  ? 131.714 153.440 171.609 1.00 138.28 ? 7   DG  C P     1 
ATOM 6014 O OP1   . DG  C 3 41  ? 130.441 153.452 172.365 1.00 133.48 ? 7   DG  C OP1   1 
ATOM 6015 O OP2   . DG  C 3 41  ? 132.596 154.628 171.639 1.00 134.21 ? 7   DG  C OP2   1 
ATOM 6016 O "O5'" . DG  C 3 41  ? 132.575 152.175 172.071 1.00 135.65 ? 7   DG  C "O5'" 1 
ATOM 6017 C "C5'" . DG  C 3 41  ? 132.001 150.876 172.022 1.00 133.87 ? 7   DG  C "C5'" 1 
ATOM 6018 C "C4'" . DG  C 3 41  ? 133.058 149.810 172.246 1.00 134.19 ? 7   DG  C "C4'" 1 
ATOM 6019 O "O4'" . DG  C 3 41  ? 133.800 149.593 171.020 1.00 134.12 ? 7   DG  C "O4'" 1 
ATOM 6020 C "C3'" . DG  C 3 41  ? 134.088 150.140 173.328 1.00 135.06 ? 7   DG  C "C3'" 1 
ATOM 6021 O "O3'" . DG  C 3 41  ? 134.165 149.070 174.259 1.00 137.24 ? 7   DG  C "O3'" 1 
ATOM 6022 C "C2'" . DG  C 3 41  ? 135.399 150.322 172.555 1.00 134.19 ? 7   DG  C "C2'" 1 
ATOM 6023 C "C1'" . DG  C 3 41  ? 135.171 149.480 171.311 1.00 134.04 ? 7   DG  C "C1'" 1 
ATOM 6024 N N9    . DG  C 3 41  ? 135.915 149.952 170.147 1.00 135.51 ? 7   DG  C N9    1 
ATOM 6025 C C8    . DG  C 3 41  ? 135.970 151.238 169.676 1.00 134.60 ? 7   DG  C C8    1 
ATOM 6026 N N7    . DG  C 3 41  ? 136.703 151.371 168.609 1.00 134.86 ? 7   DG  C N7    1 
ATOM 6027 C C5    . DG  C 3 41  ? 137.167 150.091 168.352 1.00 135.21 ? 7   DG  C C5    1 
ATOM 6028 C C6    . DG  C 3 41  ? 138.009 149.621 167.319 1.00 134.58 ? 7   DG  C C6    1 
ATOM 6029 O O6    . DG  C 3 41  ? 138.524 150.269 166.398 1.00 131.85 ? 7   DG  C O6    1 
ATOM 6030 N N1    . DG  C 3 41  ? 138.232 148.252 167.420 1.00 136.04 ? 7   DG  C N1    1 
ATOM 6031 C C2    . DG  C 3 41  ? 137.711 147.439 168.400 1.00 133.57 ? 7   DG  C C2    1 
ATOM 6032 N N2    . DG  C 3 41  ? 138.039 146.140 168.335 1.00 132.70 ? 7   DG  C N2    1 
ATOM 6033 N N3    . DG  C 3 41  ? 136.918 147.867 169.375 1.00 132.36 ? 7   DG  C N3    1 
ATOM 6034 C C4    . DG  C 3 41  ? 136.690 149.201 169.289 1.00 134.86 ? 7   DG  C C4    1 
ATOM 6035 P P     . DT  C 3 42  ? 135.021 149.226 175.609 1.00 146.87 ? 8   DT  C P     1 
ATOM 6036 O OP1   . DT  C 3 42  ? 134.232 148.621 176.706 1.00 140.92 ? 8   DT  C OP1   1 
ATOM 6037 O OP2   . DT  C 3 42  ? 135.463 150.633 175.715 1.00 142.25 ? 8   DT  C OP2   1 
ATOM 6038 O "O5'" . DT  C 3 42  ? 136.293 148.292 175.352 1.00 142.18 ? 8   DT  C "O5'" 1 
ATOM 6039 C "C5'" . DT  C 3 42  ? 136.104 146.942 174.947 1.00 139.48 ? 8   DT  C "C5'" 1 
ATOM 6040 C "C4'" . DT  C 3 42  ? 137.385 146.359 174.382 1.00 139.44 ? 8   DT  C "C4'" 1 
ATOM 6041 O "O4'" . DT  C 3 42  ? 137.724 147.034 173.146 1.00 139.63 ? 8   DT  C "O4'" 1 
ATOM 6042 C "C3'" . DT  C 3 42  ? 138.613 146.485 175.291 1.00 140.05 ? 8   DT  C "C3'" 1 
ATOM 6043 O "O3'" . DT  C 3 42  ? 139.218 145.211 175.471 1.00 139.25 ? 8   DT  C "O3'" 1 
ATOM 6044 C "C2'" . DT  C 3 42  ? 139.535 147.448 174.538 1.00 139.73 ? 8   DT  C "C2'" 1 
ATOM 6045 C "C1'" . DT  C 3 42  ? 139.114 147.214 173.097 1.00 139.94 ? 8   DT  C "C1'" 1 
ATOM 6046 N N1    . DT  C 3 42  ? 139.416 148.361 172.193 1.00 140.15 ? 8   DT  C N1    1 
ATOM 6047 C C2    . DT  C 3 42  ? 140.177 148.146 171.070 1.00 140.31 ? 8   DT  C C2    1 
ATOM 6048 O O2    . DT  C 3 42  ? 140.623 147.055 170.764 1.00 140.44 ? 8   DT  C O2    1 
ATOM 6049 N N3    . DT  C 3 42  ? 140.397 149.261 170.307 1.00 140.54 ? 8   DT  C N3    1 
ATOM 6050 C C4    . DT  C 3 42  ? 139.945 150.544 170.553 1.00 139.68 ? 8   DT  C C4    1 
ATOM 6051 O O4    . DT  C 3 42  ? 140.197 151.482 169.806 1.00 138.88 ? 8   DT  C O4    1 
ATOM 6052 C C5    . DT  C 3 42  ? 139.154 150.701 171.749 1.00 139.42 ? 8   DT  C C5    1 
ATOM 6053 C C7    . DT  C 3 42  ? 138.607 152.047 172.121 1.00 138.64 ? 8   DT  C C7    1 
ATOM 6054 C C6    . DT  C 3 42  ? 138.930 149.613 172.503 1.00 139.76 ? 8   DT  C C6    1 
ATOM 6055 P P     . DC  D 4 4   ? 145.678 143.737 161.900 1.00 144.86 ? 2   DC  D P     1 
ATOM 6056 O OP1   . DC  D 4 4   ? 146.649 142.641 161.687 1.00 139.06 ? 2   DC  D OP1   1 
ATOM 6057 O OP2   . DC  D 4 4   ? 145.163 144.497 160.738 1.00 135.83 ? 2   DC  D OP2   1 
ATOM 6058 O "O5'" . DC  D 4 4   ? 144.425 143.165 162.710 1.00 138.15 ? 2   DC  D "O5'" 1 
ATOM 6059 C "C5'" . DC  D 4 4   ? 144.630 142.469 163.933 1.00 135.46 ? 2   DC  D "C5'" 1 
ATOM 6060 C "C4'" . DC  D 4 4   ? 143.320 142.285 164.681 1.00 134.50 ? 2   DC  D "C4'" 1 
ATOM 6061 O "O4'" . DC  D 4 4   ? 142.897 143.554 165.249 1.00 136.51 ? 2   DC  D "O4'" 1 
ATOM 6062 C "C3'" . DC  D 4 4   ? 142.150 141.791 163.828 1.00 134.89 ? 2   DC  D "C3'" 1 
ATOM 6063 O "O3'" . DC  D 4 4   ? 141.404 140.816 164.544 1.00 137.55 ? 2   DC  D "O3'" 1 
ATOM 6064 C "C2'" . DC  D 4 4   ? 141.332 143.059 163.603 1.00 135.24 ? 2   DC  D "C2'" 1 
ATOM 6065 C "C1'" . DC  D 4 4   ? 141.546 143.778 164.921 1.00 136.41 ? 2   DC  D "C1'" 1 
ATOM 6066 N N1    . DC  D 4 4   ? 141.310 145.245 164.846 1.00 136.81 ? 2   DC  D N1    1 
ATOM 6067 C C2    . DC  D 4 4   ? 140.586 145.882 165.859 1.00 135.74 ? 2   DC  D C2    1 
ATOM 6068 O O2    . DC  D 4 4   ? 140.159 145.214 166.807 1.00 134.86 ? 2   DC  D O2    1 
ATOM 6069 N N3    . DC  D 4 4   ? 140.374 147.217 165.773 1.00 136.19 ? 2   DC  D N3    1 
ATOM 6070 C C4    . DC  D 4 4   ? 140.851 147.903 164.732 1.00 136.00 ? 2   DC  D C4    1 
ATOM 6071 N N4    . DC  D 4 4   ? 140.620 149.218 164.689 1.00 136.80 ? 2   DC  D N4    1 
ATOM 6072 C C5    . DC  D 4 4   ? 141.588 147.270 163.689 1.00 134.93 ? 2   DC  D C5    1 
ATOM 6073 C C6    . DC  D 4 4   ? 141.788 145.952 163.786 1.00 135.32 ? 2   DC  D C6    1 
ATOM 6074 P P     . DG  D 4 5   ? 140.438 139.796 163.763 1.00 134.25 ? 3   DG  D P     1 
ATOM 6075 O OP1   . DG  D 4 5   ? 141.010 138.440 163.919 1.00 127.93 ? 3   DG  D OP1   1 
ATOM 6076 O OP2   . DG  D 4 5   ? 140.197 140.338 162.408 1.00 130.50 ? 3   DG  D OP2   1 
ATOM 6077 O "O5'" . DG  D 4 5   ? 139.064 139.872 164.579 1.00 129.69 ? 3   DG  D "O5'" 1 
ATOM 6078 C "C5'" . DG  D 4 5   ? 139.009 139.401 165.921 1.00 128.29 ? 3   DG  D "C5'" 1 
ATOM 6079 C "C4'" . DG  D 4 5   ? 137.800 139.962 166.652 1.00 127.57 ? 3   DG  D "C4'" 1 
ATOM 6080 O "O4'" . DG  D 4 5   ? 137.890 141.409 166.713 1.00 128.52 ? 3   DG  D "O4'" 1 
ATOM 6081 C "C3'" . DG  D 4 5   ? 136.449 139.651 166.014 1.00 128.07 ? 3   DG  D "C3'" 1 
ATOM 6082 O "O3'" . DG  D 4 5   ? 135.490 139.406 167.030 1.00 129.49 ? 3   DG  D "O3'" 1 
ATOM 6083 C "C2'" . DG  D 4 5   ? 136.131 140.929 165.244 1.00 127.64 ? 3   DG  D "C2'" 1 
ATOM 6084 C "C1'" . DG  D 4 5   ? 136.725 141.987 166.159 1.00 128.93 ? 3   DG  D "C1'" 1 
ATOM 6085 N N9    . DG  D 4 5   ? 137.115 143.208 165.467 1.00 129.87 ? 3   DG  D N9    1 
ATOM 6086 C C8    . DG  D 4 5   ? 138.111 143.341 164.532 1.00 128.57 ? 3   DG  D C8    1 
ATOM 6087 N N7    . DG  D 4 5   ? 138.248 144.556 164.086 1.00 128.13 ? 3   DG  D N7    1 
ATOM 6088 C C5    . DG  D 4 5   ? 137.283 145.280 164.772 1.00 127.88 ? 3   DG  D C5    1 
ATOM 6089 C C6    . DG  D 4 5   ? 136.959 146.652 164.703 1.00 127.62 ? 3   DG  D C6    1 
ATOM 6090 O O6    . DG  D 4 5   ? 137.480 147.523 163.996 1.00 126.83 ? 3   DG  D O6    1 
ATOM 6091 N N1    . DG  D 4 5   ? 135.913 146.980 165.561 1.00 128.15 ? 3   DG  D N1    1 
ATOM 6092 C C2    . DG  D 4 5   ? 135.265 146.092 166.387 1.00 127.78 ? 3   DG  D C2    1 
ATOM 6093 N N2    . DG  D 4 5   ? 134.279 146.593 167.148 1.00 127.22 ? 3   DG  D N2    1 
ATOM 6094 N N3    . DG  D 4 5   ? 135.560 144.800 166.461 1.00 128.85 ? 3   DG  D N3    1 
ATOM 6095 C C4    . DG  D 4 5   ? 136.577 144.465 165.628 1.00 129.00 ? 3   DG  D C4    1 
ATOM 6096 P P     . DA  D 4 6   ? 134.063 138.768 166.659 1.00 124.31 ? 4   DA  D P     1 
ATOM 6097 O OP1   . DA  D 4 6   ? 133.700 137.824 167.738 1.00 116.43 ? 4   DA  D OP1   1 
ATOM 6098 O OP2   . DA  D 4 6   ? 134.138 138.290 165.261 1.00 117.47 ? 4   DA  D OP2   1 
ATOM 6099 O "O5'" . DA  D 4 6   ? 133.065 140.017 166.699 1.00 118.54 ? 4   DA  D "O5'" 1 
ATOM 6100 C "C5'" . DA  D 4 6   ? 132.965 140.815 167.876 1.00 115.03 ? 4   DA  D "C5'" 1 
ATOM 6101 C "C4'" . DA  D 4 6   ? 131.835 141.825 167.754 1.00 114.09 ? 4   DA  D "C4'" 1 
ATOM 6102 O "O4'" . DA  D 4 6   ? 132.329 143.044 167.142 1.00 116.26 ? 4   DA  D "O4'" 1 
ATOM 6103 C "C3'" . DA  D 4 6   ? 130.659 141.375 166.899 1.00 113.79 ? 4   DA  D "C3'" 1 
ATOM 6104 O "O3'" . DA  D 4 6   ? 129.446 141.869 167.444 1.00 114.66 ? 4   DA  D "O3'" 1 
ATOM 6105 C "C2'" . DA  D 4 6   ? 130.963 141.999 165.538 1.00 112.56 ? 4   DA  D "C2'" 1 
ATOM 6106 C "C1'" . DA  D 4 6   ? 131.637 143.303 165.935 1.00 113.57 ? 4   DA  D "C1'" 1 
ATOM 6107 N N9    . DA  D 4 6   ? 132.611 143.772 164.957 1.00 113.39 ? 4   DA  D N9    1 
ATOM 6108 C C8    . DA  D 4 6   ? 133.550 143.022 164.312 1.00 113.07 ? 4   DA  D C8    1 
ATOM 6109 N N7    . DA  D 4 6   ? 134.306 143.710 163.494 1.00 114.17 ? 4   DA  D N7    1 
ATOM 6110 C C5    . DA  D 4 6   ? 133.836 145.004 163.615 1.00 115.52 ? 4   DA  D C5    1 
ATOM 6111 C C6    . DA  D 4 6   ? 134.221 146.210 163.004 1.00 116.84 ? 4   DA  D C6    1 
ATOM 6112 N N6    . DA  D 4 6   ? 135.215 146.295 162.117 1.00 116.06 ? 4   DA  D N6    1 
ATOM 6113 N N1    . DA  D 4 6   ? 133.548 147.328 163.344 1.00 115.72 ? 4   DA  D N1    1 
ATOM 6114 C C2    . DA  D 4 6   ? 132.553 147.236 164.235 1.00 115.65 ? 4   DA  D C2    1 
ATOM 6115 N N3    . DA  D 4 6   ? 132.100 146.156 164.875 1.00 114.66 ? 4   DA  D N3    1 
ATOM 6116 C C4    . DA  D 4 6   ? 132.791 145.063 164.515 1.00 114.27 ? 4   DA  D C4    1 
ATOM 6117 P P     . DT  D 4 7   ? 128.088 141.037 167.240 1.00 104.04 ? 5   DT  D P     1 
ATOM 6118 O OP1   . DT  D 4 7   ? 126.971 141.842 167.782 1.00 97.02  ? 5   DT  D OP1   1 
ATOM 6119 O OP2   . DT  D 4 7   ? 128.328 139.683 167.788 1.00 101.06 ? 5   DT  D OP2   1 
ATOM 6120 O "O5'" . DT  D 4 7   ? 127.978 140.894 165.649 1.00 101.05 ? 5   DT  D "O5'" 1 
ATOM 6121 C "C5'" . DT  D 4 7   ? 126.872 141.445 164.941 1.00 99.27  ? 5   DT  D "C5'" 1 
ATOM 6122 C "C4'" . DT  D 4 7   ? 126.930 142.965 164.906 1.00 96.02  ? 5   DT  D "C4'" 1 
ATOM 6123 O "O4'" . DT  D 4 7   ? 128.249 143.409 164.494 1.00 97.33  ? 5   DT  D "O4'" 1 
ATOM 6124 C "C3'" . DT  D 4 7   ? 125.939 143.619 163.945 1.00 94.34  ? 5   DT  D "C3'" 1 
ATOM 6125 O "O3'" . DT  D 4 7   ? 125.247 144.656 164.601 1.00 96.27  ? 5   DT  D "O3'" 1 
ATOM 6126 C "C2'" . DT  D 4 7   ? 126.823 144.153 162.819 1.00 95.96  ? 5   DT  D "C2'" 1 
ATOM 6127 C "C1'" . DT  D 4 7   ? 128.113 144.450 163.556 1.00 94.73  ? 5   DT  D "C1'" 1 
ATOM 6128 N N1    . DT  D 4 7   ? 129.320 144.452 162.679 1.00 94.72  ? 5   DT  D N1    1 
ATOM 6129 C C2    . DT  D 4 7   ? 129.769 145.639 162.143 1.00 92.51  ? 5   DT  D C2    1 
ATOM 6130 O O2    . DT  D 4 7   ? 129.228 146.710 162.343 1.00 91.51  ? 5   DT  D O2    1 
ATOM 6131 N N3    . DT  D 4 7   ? 130.886 145.523 161.358 1.00 93.63  ? 5   DT  D N3    1 
ATOM 6132 C C4    . DT  D 4 7   ? 131.583 144.365 161.063 1.00 96.18  ? 5   DT  D C4    1 
ATOM 6133 O O4    . DT  D 4 7   ? 132.578 144.360 160.348 1.00 97.30  ? 5   DT  D O4    1 
ATOM 6134 C C5    . DT  D 4 7   ? 131.057 143.161 161.658 1.00 95.65  ? 5   DT  D C5    1 
ATOM 6135 C C7    . DT  D 4 7   ? 131.730 141.844 161.410 1.00 97.66  ? 5   DT  D C7    1 
ATOM 6136 C C6    . DT  D 4 7   ? 129.966 143.263 162.426 1.00 95.34  ? 5   DT  D C6    1 
ATOM 6137 P P     . DA  D 4 8   ? 123.739 145.000 164.178 1.00 89.86  ? 6   DA  D P     1 
ATOM 6138 O OP1   . DA  D 4 8   ? 123.080 145.618 165.347 1.00 80.24  ? 6   DA  D OP1   1 
ATOM 6139 O OP2   . DA  D 4 8   ? 123.164 143.785 163.562 1.00 78.90  ? 6   DA  D OP2   1 
ATOM 6140 O "O5'" . DA  D 4 8   ? 123.911 146.093 163.025 1.00 72.86  ? 6   DA  D "O5'" 1 
ATOM 6141 C "C5'" . DA  D 4 8   ? 124.668 147.265 163.272 1.00 78.05  ? 6   DA  D "C5'" 1 
ATOM 6142 C "C4'" . DA  D 4 8   ? 124.738 148.133 162.032 1.00 74.26  ? 6   DA  D "C4'" 1 
ATOM 6143 O "O4'" . DA  D 4 8   ? 126.002 147.918 161.355 1.00 72.99  ? 6   DA  D "O4'" 1 
ATOM 6144 C "C3'" . DA  D 4 8   ? 123.648 147.863 160.998 1.00 68.47  ? 6   DA  D "C3'" 1 
ATOM 6145 O "O3'" . DA  D 4 8   ? 123.158 149.089 160.486 1.00 73.30  ? 6   DA  D "O3'" 1 
ATOM 6146 C "C2'" . DA  D 4 8   ? 124.380 147.062 159.927 1.00 72.82  ? 6   DA  D "C2'" 1 
ATOM 6147 C "C1'" . DA  D 4 8   ? 125.767 147.670 159.991 1.00 70.04  ? 6   DA  D "C1'" 1 
ATOM 6148 N N9    . DA  D 4 8   ? 126.813 146.785 159.495 1.00 69.61  ? 6   DA  D N9    1 
ATOM 6149 C C8    . DA  D 4 8   ? 126.927 145.443 159.714 1.00 73.32  ? 6   DA  D C8    1 
ATOM 6150 N N7    . DA  D 4 8   ? 127.978 144.902 159.146 1.00 73.99  ? 6   DA  D N7    1 
ATOM 6151 C C5    . DA  D 4 8   ? 128.593 145.964 158.512 1.00 74.55  ? 6   DA  D C5    1 
ATOM 6152 C C6    . DA  D 4 8   ? 129.759 146.054 157.730 1.00 77.90  ? 6   DA  D C6    1 
ATOM 6153 N N6    . DA  D 4 8   ? 130.538 145.004 157.450 1.00 78.54  ? 6   DA  D N6    1 
ATOM 6154 N N1    . DA  D 4 8   ? 130.094 147.265 157.245 1.00 77.28  ? 6   DA  D N1    1 
ATOM 6155 C C2    . DA  D 4 8   ? 129.310 148.310 157.526 1.00 73.25  ? 6   DA  D C2    1 
ATOM 6156 N N3    . DA  D 4 8   ? 128.196 148.349 158.251 1.00 74.15  ? 6   DA  D N3    1 
ATOM 6157 C C4    . DA  D 4 8   ? 127.889 147.132 158.717 1.00 74.40  ? 6   DA  D C4    1 
ATOM 6158 P P     . DT  D 4 9   ? 121.827 149.128 159.590 1.00 65.62  ? 7   DT  D P     1 
ATOM 6159 O OP1   . DT  D 4 9   ? 120.897 150.086 160.221 1.00 70.48  ? 7   DT  D OP1   1 
ATOM 6160 O OP2   . DT  D 4 9   ? 121.378 147.741 159.341 1.00 67.64  ? 7   DT  D OP2   1 
ATOM 6161 O "O5'" . DT  D 4 9   ? 122.330 149.750 158.209 1.00 69.43  ? 7   DT  D "O5'" 1 
ATOM 6162 C "C5'" . DT  D 4 9   ? 122.995 151.003 158.209 1.00 63.62  ? 7   DT  D "C5'" 1 
ATOM 6163 C "C4'" . DT  D 4 9   ? 123.867 151.157 156.979 1.00 61.44  ? 7   DT  D "C4'" 1 
ATOM 6164 O "O4'" . DT  D 4 9   ? 124.851 150.089 156.942 1.00 65.95  ? 7   DT  D "O4'" 1 
ATOM 6165 C "C3'" . DT  D 4 9   ? 123.123 151.093 155.642 1.00 62.58  ? 7   DT  D "C3'" 1 
ATOM 6166 O "O3'" . DT  D 4 9   ? 123.619 152.098 154.769 1.00 71.08  ? 7   DT  D "O3'" 1 
ATOM 6167 C "C2'" . DT  D 4 9   ? 123.469 149.698 155.127 1.00 67.33  ? 7   DT  D "C2'" 1 
ATOM 6168 C "C1'" . DT  D 4 9   ? 124.887 149.559 155.642 1.00 66.65  ? 7   DT  D "C1'" 1 
ATOM 6169 N N1    . DT  D 4 9   ? 125.373 148.157 155.702 1.00 60.87  ? 7   DT  D N1    1 
ATOM 6170 C C2    . DT  D 4 9   ? 126.571 147.841 155.113 1.00 63.62  ? 7   DT  D C2    1 
ATOM 6171 O O2    . DT  D 4 9   ? 127.269 148.657 154.545 1.00 68.31  ? 7   DT  D O2    1 
ATOM 6172 N N3    . DT  D 4 9   ? 126.931 146.526 155.216 1.00 65.71  ? 7   DT  D N3    1 
ATOM 6173 C C4    . DT  D 4 9   ? 126.225 145.515 155.835 1.00 68.74  ? 7   DT  D C4    1 
ATOM 6174 O O4    . DT  D 4 9   ? 126.632 144.361 155.875 1.00 73.68  ? 7   DT  D O4    1 
ATOM 6175 C C5    . DT  D 4 9   ? 124.972 145.911 156.431 1.00 60.73  ? 7   DT  D C5    1 
ATOM 6176 C C7    . DT  D 4 9   ? 124.117 144.899 157.129 1.00 63.16  ? 7   DT  D C7    1 
ATOM 6177 C C6    . DT  D 4 9   ? 124.610 147.199 156.336 1.00 60.77  ? 7   DT  D C6    1 
ATOM 6178 P P     . DG  D 4 10  ? 122.652 152.788 153.689 1.00 78.12  ? 8   DG  D P     1 
ATOM 6179 O OP1   . DG  D 4 10  ? 121.716 153.670 154.417 1.00 72.20  ? 8   DG  D OP1   1 
ATOM 6180 O OP2   . DG  D 4 10  ? 122.127 151.727 152.804 1.00 69.73  ? 8   DG  D OP2   1 
ATOM 6181 O "O5'" . DG  D 4 10  ? 123.640 153.693 152.820 1.00 67.90  ? 8   DG  D "O5'" 1 
ATOM 6182 C "C5'" . DG  D 4 10  ? 124.002 153.287 151.507 1.00 68.18  ? 8   DG  D "C5'" 1 
ATOM 6183 C "C4'" . DG  D 4 10  ? 125.495 153.449 151.282 1.00 68.31  ? 8   DG  D "C4'" 1 
ATOM 6184 O "O4'" . DG  D 4 10  ? 126.190 152.322 151.860 1.00 60.75  ? 8   DG  D "O4'" 1 
ATOM 6185 C "C3'" . DG  D 4 10  ? 125.920 153.452 149.828 1.00 69.92  ? 8   DG  D "C3'" 1 
ATOM 6186 O "O3'" . DG  D 4 10  ? 127.184 154.085 149.693 1.00 66.68  ? 8   DG  D "O3'" 1 
ATOM 6187 C "C2'" . DG  D 4 10  ? 126.005 151.961 149.525 1.00 66.46  ? 8   DG  D "C2'" 1 
ATOM 6188 C "C1'" . DG  D 4 10  ? 126.535 151.398 150.844 1.00 62.47  ? 8   DG  D "C1'" 1 
ATOM 6189 N N9    . DG  D 4 10  ? 125.965 150.103 151.195 1.00 67.40  ? 8   DG  D N9    1 
ATOM 6190 C C8    . DG  D 4 10  ? 124.894 149.872 152.021 1.00 67.39  ? 8   DG  D C8    1 
ATOM 6191 N N7    . DG  D 4 10  ? 124.604 148.609 152.159 1.00 62.95  ? 8   DG  D N7    1 
ATOM 6192 C C5    . DG  D 4 10  ? 125.544 147.960 151.375 1.00 58.34  ? 8   DG  D C5    1 
ATOM 6193 C C6    . DG  D 4 10  ? 125.727 146.581 151.133 1.00 61.87  ? 8   DG  D C6    1 
ATOM 6194 O O6    . DG  D 4 10  ? 125.072 145.631 151.581 1.00 70.34  ? 8   DG  D O6    1 
ATOM 6195 N N1    . DG  D 4 10  ? 126.796 146.345 150.277 1.00 62.31  ? 8   DG  D N1    1 
ATOM 6196 C C2    . DG  D 4 10  ? 127.587 147.319 149.721 1.00 60.56  ? 8   DG  D C2    1 
ATOM 6197 N N2    . DG  D 4 10  ? 128.571 146.897 148.917 1.00 62.16  ? 8   DG  D N2    1 
ATOM 6198 N N3    . DG  D 4 10  ? 127.429 148.617 149.941 1.00 67.41  ? 8   DG  D N3    1 
ATOM 6199 C C4    . DG  D 4 10  ? 126.390 148.863 150.774 1.00 66.73  ? 8   DG  D C4    1 
# 
