data_8ZQ2
# 
_entry.id   8ZQ2 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZQ2         pdb_00008zq2 10.2210/pdb8zq2/pdb 
WWPDB D_1300048342 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZQ2 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-31 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              hbluo@hainanu.edu.cn 
_pdbx_contact_author.name_first         Hai-Bin 
_pdbx_contact_author.name_last          Luo 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2163-0509 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Huang, Y.-Y.' 1 ? 
'Luo, H.-B.'   2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   CC 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Chin.Chem.Lett. 
_citation.journal_id_ASTM           CCLEE7 
_citation.journal_id_CSD            1182 
_citation.journal_id_ISSN           1001-8417 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                110586 
_citation.page_last                 ? 
_citation.title                     
'Structure-based optimization of isoaurostatin as novel PDE4 inhibitors with anti-fibrotic effects' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.cclet.2024.110586 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Huang, Y.Y.' 1  ? 
primary 'Luo, X.'     2  ? 
primary 'Zhang, K.'   3  ? 
primary 'Liang, Y.'   4  ? 
primary 'Zhang, F.'   5  ? 
primary 'Liao, G.'    6  ? 
primary 'Xie, S.'     7  ? 
primary 'Huang, P.L.' 8  ? 
primary 'Hou, S.'     9  ? 
primary 'Zhou, Q.'    10 ? 
primary 'Zou, Y.'     11 ? 
primary 'Luo, H.B.'   12 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 
;3',5'-cyclic-AMP phosphodiesterase 4D
;
57758.402 2   3.1.4.53 ? ? ? 
2 non-polymer syn 'ZINC ION'                                                                         65.409    2   ?        ? ? ? 
3 non-polymer syn 'MAGNESIUM ION'                                                                    24.305    2   ?        ? ? ? 
4 non-polymer syn '(3~{Z})-3-[(3-ethoxy-4-methoxy-phenyl)methylidene]-6-oxidanyl-1-benzofuran-2-one' 312.317   2   ?        ? ? ? 
5 water       nat water                                                                              18.015    209 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'DPDE3,PDE43,cAMP-specific phosphodiesterase 4D' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIP
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL
LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLS
NPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE
QVEEEAVGEEEESQPEACVIDDRSPD
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIP
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL
LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLS
NPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE
QVEEEAVGEEEESQPEACVIDDRSPD
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                                                         ZN    
3 'MAGNESIUM ION'                                                                    MG    
4 '(3~{Z})-3-[(3-ethoxy-4-methoxy-phenyl)methylidene]-6-oxidanyl-1-benzofuran-2-one' A1D8O 
5 water                                                                              HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   SER n 
1 4   ASN n 
1 5   LYS n 
1 6   PHE n 
1 7   LYS n 
1 8   ARG n 
1 9   MET n 
1 10  LEU n 
1 11  ASN n 
1 12  ARG n 
1 13  GLU n 
1 14  LEU n 
1 15  THR n 
1 16  HIS n 
1 17  LEU n 
1 18  SER n 
1 19  GLU n 
1 20  MET n 
1 21  SER n 
1 22  ARG n 
1 23  SER n 
1 24  GLY n 
1 25  ASN n 
1 26  GLN n 
1 27  VAL n 
1 28  SER n 
1 29  GLU n 
1 30  PHE n 
1 31  ILE n 
1 32  SER n 
1 33  ASN n 
1 34  THR n 
1 35  PHE n 
1 36  LEU n 
1 37  ASP n 
1 38  LYS n 
1 39  GLN n 
1 40  HIS n 
1 41  GLU n 
1 42  VAL n 
1 43  GLU n 
1 44  ILE n 
1 45  PRO n 
1 46  SER n 
1 47  PRO n 
1 48  THR n 
1 49  GLN n 
1 50  LYS n 
1 51  GLU n 
1 52  LYS n 
1 53  GLU n 
1 54  LYS n 
1 55  LYS n 
1 56  LYS n 
1 57  ARG n 
1 58  PRO n 
1 59  MET n 
1 60  SER n 
1 61  GLN n 
1 62  ILE n 
1 63  SER n 
1 64  GLY n 
1 65  VAL n 
1 66  LYS n 
1 67  LYS n 
1 68  LEU n 
1 69  MET n 
1 70  HIS n 
1 71  SER n 
1 72  SER n 
1 73  SER n 
1 74  LEU n 
1 75  THR n 
1 76  ASN n 
1 77  SER n 
1 78  SER n 
1 79  ILE n 
1 80  PRO n 
1 81  ARG n 
1 82  PHE n 
1 83  GLY n 
1 84  VAL n 
1 85  LYS n 
1 86  THR n 
1 87  GLU n 
1 88  GLN n 
1 89  GLU n 
1 90  ASP n 
1 91  VAL n 
1 92  LEU n 
1 93  ALA n 
1 94  LYS n 
1 95  GLU n 
1 96  LEU n 
1 97  GLU n 
1 98  ASP n 
1 99  VAL n 
1 100 ASN n 
1 101 LYS n 
1 102 TRP n 
1 103 GLY n 
1 104 LEU n 
1 105 HIS n 
1 106 VAL n 
1 107 PHE n 
1 108 ARG n 
1 109 ILE n 
1 110 ALA n 
1 111 GLU n 
1 112 LEU n 
1 113 SER n 
1 114 GLY n 
1 115 ASN n 
1 116 ARG n 
1 117 PRO n 
1 118 LEU n 
1 119 THR n 
1 120 VAL n 
1 121 ILE n 
1 122 MET n 
1 123 HIS n 
1 124 THR n 
1 125 ILE n 
1 126 PHE n 
1 127 GLN n 
1 128 GLU n 
1 129 ARG n 
1 130 ASP n 
1 131 LEU n 
1 132 LEU n 
1 133 LYS n 
1 134 THR n 
1 135 PHE n 
1 136 LYS n 
1 137 ILE n 
1 138 PRO n 
1 139 VAL n 
1 140 ASP n 
1 141 THR n 
1 142 LEU n 
1 143 ILE n 
1 144 THR n 
1 145 TYR n 
1 146 LEU n 
1 147 MET n 
1 148 THR n 
1 149 LEU n 
1 150 GLU n 
1 151 ASP n 
1 152 HIS n 
1 153 TYR n 
1 154 HIS n 
1 155 ALA n 
1 156 ASP n 
1 157 VAL n 
1 158 ALA n 
1 159 TYR n 
1 160 HIS n 
1 161 ASN n 
1 162 ASN n 
1 163 ILE n 
1 164 HIS n 
1 165 ALA n 
1 166 ALA n 
1 167 ASP n 
1 168 VAL n 
1 169 VAL n 
1 170 GLN n 
1 171 SER n 
1 172 THR n 
1 173 HIS n 
1 174 VAL n 
1 175 LEU n 
1 176 LEU n 
1 177 SER n 
1 178 THR n 
1 179 PRO n 
1 180 ALA n 
1 181 LEU n 
1 182 GLU n 
1 183 ALA n 
1 184 VAL n 
1 185 PHE n 
1 186 THR n 
1 187 ASP n 
1 188 LEU n 
1 189 GLU n 
1 190 ILE n 
1 191 LEU n 
1 192 ALA n 
1 193 ALA n 
1 194 ILE n 
1 195 PHE n 
1 196 ALA n 
1 197 SER n 
1 198 ALA n 
1 199 ILE n 
1 200 HIS n 
1 201 ASP n 
1 202 VAL n 
1 203 ASP n 
1 204 HIS n 
1 205 PRO n 
1 206 GLY n 
1 207 VAL n 
1 208 SER n 
1 209 ASN n 
1 210 GLN n 
1 211 PHE n 
1 212 LEU n 
1 213 ILE n 
1 214 ASN n 
1 215 THR n 
1 216 ASN n 
1 217 SER n 
1 218 GLU n 
1 219 LEU n 
1 220 ALA n 
1 221 LEU n 
1 222 MET n 
1 223 TYR n 
1 224 ASN n 
1 225 ASP n 
1 226 SER n 
1 227 SER n 
1 228 VAL n 
1 229 LEU n 
1 230 GLU n 
1 231 ASN n 
1 232 HIS n 
1 233 HIS n 
1 234 LEU n 
1 235 ALA n 
1 236 VAL n 
1 237 GLY n 
1 238 PHE n 
1 239 LYS n 
1 240 LEU n 
1 241 LEU n 
1 242 GLN n 
1 243 GLU n 
1 244 GLU n 
1 245 ASN n 
1 246 CYS n 
1 247 ASP n 
1 248 ILE n 
1 249 PHE n 
1 250 GLN n 
1 251 ASN n 
1 252 LEU n 
1 253 THR n 
1 254 LYS n 
1 255 LYS n 
1 256 GLN n 
1 257 ARG n 
1 258 GLN n 
1 259 SER n 
1 260 LEU n 
1 261 ARG n 
1 262 LYS n 
1 263 MET n 
1 264 VAL n 
1 265 ILE n 
1 266 ASP n 
1 267 ILE n 
1 268 VAL n 
1 269 LEU n 
1 270 ALA n 
1 271 THR n 
1 272 ASP n 
1 273 MET n 
1 274 SER n 
1 275 LYS n 
1 276 HIS n 
1 277 MET n 
1 278 ASN n 
1 279 LEU n 
1 280 LEU n 
1 281 ALA n 
1 282 ASP n 
1 283 LEU n 
1 284 LYS n 
1 285 THR n 
1 286 MET n 
1 287 VAL n 
1 288 GLU n 
1 289 THR n 
1 290 LYS n 
1 291 LYS n 
1 292 VAL n 
1 293 THR n 
1 294 SER n 
1 295 SER n 
1 296 GLY n 
1 297 VAL n 
1 298 LEU n 
1 299 LEU n 
1 300 LEU n 
1 301 ASP n 
1 302 ASN n 
1 303 TYR n 
1 304 SER n 
1 305 ASP n 
1 306 ARG n 
1 307 ILE n 
1 308 GLN n 
1 309 VAL n 
1 310 LEU n 
1 311 GLN n 
1 312 ASN n 
1 313 MET n 
1 314 VAL n 
1 315 HIS n 
1 316 CYS n 
1 317 ALA n 
1 318 ASP n 
1 319 LEU n 
1 320 SER n 
1 321 ASN n 
1 322 PRO n 
1 323 THR n 
1 324 LYS n 
1 325 PRO n 
1 326 LEU n 
1 327 GLN n 
1 328 LEU n 
1 329 TYR n 
1 330 ARG n 
1 331 GLN n 
1 332 TRP n 
1 333 THR n 
1 334 ASP n 
1 335 ARG n 
1 336 ILE n 
1 337 MET n 
1 338 GLU n 
1 339 GLU n 
1 340 PHE n 
1 341 PHE n 
1 342 ARG n 
1 343 GLN n 
1 344 GLY n 
1 345 ASP n 
1 346 ARG n 
1 347 GLU n 
1 348 ARG n 
1 349 GLU n 
1 350 ARG n 
1 351 GLY n 
1 352 MET n 
1 353 GLU n 
1 354 ILE n 
1 355 SER n 
1 356 PRO n 
1 357 MET n 
1 358 CYS n 
1 359 ASP n 
1 360 LYS n 
1 361 HIS n 
1 362 ASN n 
1 363 ALA n 
1 364 SER n 
1 365 VAL n 
1 366 GLU n 
1 367 LYS n 
1 368 SER n 
1 369 GLN n 
1 370 VAL n 
1 371 GLY n 
1 372 PHE n 
1 373 ILE n 
1 374 ASP n 
1 375 TYR n 
1 376 ILE n 
1 377 VAL n 
1 378 HIS n 
1 379 PRO n 
1 380 LEU n 
1 381 TRP n 
1 382 GLU n 
1 383 THR n 
1 384 TRP n 
1 385 ALA n 
1 386 ASP n 
1 387 LEU n 
1 388 VAL n 
1 389 HIS n 
1 390 PRO n 
1 391 ASP n 
1 392 ALA n 
1 393 GLN n 
1 394 ASP n 
1 395 ILE n 
1 396 LEU n 
1 397 ASP n 
1 398 THR n 
1 399 LEU n 
1 400 GLU n 
1 401 ASP n 
1 402 ASN n 
1 403 ARG n 
1 404 GLU n 
1 405 TRP n 
1 406 TYR n 
1 407 GLN n 
1 408 SER n 
1 409 THR n 
1 410 ILE n 
1 411 PRO n 
1 412 GLN n 
1 413 SER n 
1 414 PRO n 
1 415 SER n 
1 416 PRO n 
1 417 ALA n 
1 418 PRO n 
1 419 ASP n 
1 420 ASP n 
1 421 PRO n 
1 422 GLU n 
1 423 GLU n 
1 424 GLY n 
1 425 ARG n 
1 426 GLN n 
1 427 GLY n 
1 428 GLN n 
1 429 THR n 
1 430 GLU n 
1 431 LYS n 
1 432 PHE n 
1 433 GLN n 
1 434 PHE n 
1 435 GLU n 
1 436 LEU n 
1 437 THR n 
1 438 LEU n 
1 439 GLU n 
1 440 GLU n 
1 441 ASP n 
1 442 GLY n 
1 443 GLU n 
1 444 SER n 
1 445 ASP n 
1 446 THR n 
1 447 GLU n 
1 448 LYS n 
1 449 ASP n 
1 450 SER n 
1 451 GLY n 
1 452 SER n 
1 453 GLN n 
1 454 VAL n 
1 455 GLU n 
1 456 GLU n 
1 457 ASP n 
1 458 THR n 
1 459 SER n 
1 460 CYS n 
1 461 SER n 
1 462 ASP n 
1 463 SER n 
1 464 LYS n 
1 465 THR n 
1 466 LEU n 
1 467 CYS n 
1 468 THR n 
1 469 GLN n 
1 470 ASP n 
1 471 SER n 
1 472 GLU n 
1 473 SER n 
1 474 THR n 
1 475 GLU n 
1 476 ILE n 
1 477 PRO n 
1 478 LEU n 
1 479 ASP n 
1 480 GLU n 
1 481 GLN n 
1 482 VAL n 
1 483 GLU n 
1 484 GLU n 
1 485 GLU n 
1 486 ALA n 
1 487 VAL n 
1 488 GLY n 
1 489 GLU n 
1 490 GLU n 
1 491 GLU n 
1 492 GLU n 
1 493 SER n 
1 494 GLN n 
1 495 PRO n 
1 496 GLU n 
1 497 ALA n 
1 498 CYS n 
1 499 VAL n 
1 500 ILE n 
1 501 ASP n 
1 502 ASP n 
1 503 ARG n 
1 504 SER n 
1 505 PRO n 
1 506 ASP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   506 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'PDE4D, DPDE3' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     511693 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1D8O non-polymer         . '(3~{Z})-3-[(3-ethoxy-4-methoxy-phenyl)methylidene]-6-oxidanyl-1-benzofuran-2-one' 'LDC271 INHIBITOR' 
'C18 H16 O5'     312.317 
ALA   'L-peptide linking' y ALANINE                                                                            ?                  
'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE                                                                           ?                  
'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE                                                                         ?                  
'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                                                    ?                  
'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE                                                                           ?                  
'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE                                                                          ?                  
'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                                                    ?                  
'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE                                                                            ?                  
'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE                                                                          ?                  
'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER                                                                              ?                  
'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE                                                                         ?                  
'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE                                                                            ?                  
'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE                                                                             ?                  
'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE                                                                         ?                  
'C5 H11 N O2 S'  149.211 
MG    non-polymer         . 'MAGNESIUM ION'                                                                    ?                  
'Mg 2'           24.305  
PHE   'L-peptide linking' y PHENYLALANINE                                                                      ?                  
'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE                                                                            ?                  
'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE                                                                             ?                  
'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE                                                                          ?                  
'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                                                         ?                  
'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE                                                                           ?                  
'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE                                                                             ?                  
'C5 H11 N O2'    117.146 
ZN    non-polymer         . 'ZINC ION'                                                                         ?                  
'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   SER 3   3   ?   ?   ?   A . n 
A 1 4   ASN 4   4   ?   ?   ?   A . n 
A 1 5   LYS 5   5   ?   ?   ?   A . n 
A 1 6   PHE 6   6   ?   ?   ?   A . n 
A 1 7   LYS 7   7   ?   ?   ?   A . n 
A 1 8   ARG 8   8   ?   ?   ?   A . n 
A 1 9   MET 9   9   ?   ?   ?   A . n 
A 1 10  LEU 10  10  ?   ?   ?   A . n 
A 1 11  ASN 11  11  ?   ?   ?   A . n 
A 1 12  ARG 12  12  ?   ?   ?   A . n 
A 1 13  GLU 13  13  ?   ?   ?   A . n 
A 1 14  LEU 14  14  ?   ?   ?   A . n 
A 1 15  THR 15  15  ?   ?   ?   A . n 
A 1 16  HIS 16  16  ?   ?   ?   A . n 
A 1 17  LEU 17  17  ?   ?   ?   A . n 
A 1 18  SER 18  18  ?   ?   ?   A . n 
A 1 19  GLU 19  19  ?   ?   ?   A . n 
A 1 20  MET 20  20  ?   ?   ?   A . n 
A 1 21  SER 21  21  ?   ?   ?   A . n 
A 1 22  ARG 22  22  ?   ?   ?   A . n 
A 1 23  SER 23  23  ?   ?   ?   A . n 
A 1 24  GLY 24  24  ?   ?   ?   A . n 
A 1 25  ASN 25  25  ?   ?   ?   A . n 
A 1 26  GLN 26  26  ?   ?   ?   A . n 
A 1 27  VAL 27  27  ?   ?   ?   A . n 
A 1 28  SER 28  28  ?   ?   ?   A . n 
A 1 29  GLU 29  29  ?   ?   ?   A . n 
A 1 30  PHE 30  30  ?   ?   ?   A . n 
A 1 31  ILE 31  31  ?   ?   ?   A . n 
A 1 32  SER 32  32  ?   ?   ?   A . n 
A 1 33  ASN 33  33  ?   ?   ?   A . n 
A 1 34  THR 34  34  ?   ?   ?   A . n 
A 1 35  PHE 35  35  ?   ?   ?   A . n 
A 1 36  LEU 36  36  ?   ?   ?   A . n 
A 1 37  ASP 37  37  ?   ?   ?   A . n 
A 1 38  LYS 38  38  ?   ?   ?   A . n 
A 1 39  GLN 39  39  ?   ?   ?   A . n 
A 1 40  HIS 40  40  ?   ?   ?   A . n 
A 1 41  GLU 41  41  ?   ?   ?   A . n 
A 1 42  VAL 42  42  ?   ?   ?   A . n 
A 1 43  GLU 43  43  ?   ?   ?   A . n 
A 1 44  ILE 44  44  ?   ?   ?   A . n 
A 1 45  PRO 45  45  ?   ?   ?   A . n 
A 1 46  SER 46  46  ?   ?   ?   A . n 
A 1 47  PRO 47  47  ?   ?   ?   A . n 
A 1 48  THR 48  48  ?   ?   ?   A . n 
A 1 49  GLN 49  49  ?   ?   ?   A . n 
A 1 50  LYS 50  50  ?   ?   ?   A . n 
A 1 51  GLU 51  51  ?   ?   ?   A . n 
A 1 52  LYS 52  52  ?   ?   ?   A . n 
A 1 53  GLU 53  53  ?   ?   ?   A . n 
A 1 54  LYS 54  54  ?   ?   ?   A . n 
A 1 55  LYS 55  55  ?   ?   ?   A . n 
A 1 56  LYS 56  56  ?   ?   ?   A . n 
A 1 57  ARG 57  57  ?   ?   ?   A . n 
A 1 58  PRO 58  58  ?   ?   ?   A . n 
A 1 59  MET 59  59  ?   ?   ?   A . n 
A 1 60  SER 60  60  ?   ?   ?   A . n 
A 1 61  GLN 61  61  ?   ?   ?   A . n 
A 1 62  ILE 62  62  ?   ?   ?   A . n 
A 1 63  SER 63  63  ?   ?   ?   A . n 
A 1 64  GLY 64  64  ?   ?   ?   A . n 
A 1 65  VAL 65  65  ?   ?   ?   A . n 
A 1 66  LYS 66  66  ?   ?   ?   A . n 
A 1 67  LYS 67  67  ?   ?   ?   A . n 
A 1 68  LEU 68  68  ?   ?   ?   A . n 
A 1 69  MET 69  69  ?   ?   ?   A . n 
A 1 70  HIS 70  70  ?   ?   ?   A . n 
A 1 71  SER 71  71  ?   ?   ?   A . n 
A 1 72  SER 72  72  ?   ?   ?   A . n 
A 1 73  SER 73  73  ?   ?   ?   A . n 
A 1 74  LEU 74  74  ?   ?   ?   A . n 
A 1 75  THR 75  75  ?   ?   ?   A . n 
A 1 76  ASN 76  76  ?   ?   ?   A . n 
A 1 77  SER 77  77  ?   ?   ?   A . n 
A 1 78  SER 78  78  ?   ?   ?   A . n 
A 1 79  ILE 79  79  ?   ?   ?   A . n 
A 1 80  PRO 80  80  ?   ?   ?   A . n 
A 1 81  ARG 81  81  ?   ?   ?   A . n 
A 1 82  PHE 82  82  ?   ?   ?   A . n 
A 1 83  GLY 83  83  ?   ?   ?   A . n 
A 1 84  VAL 84  84  ?   ?   ?   A . n 
A 1 85  LYS 85  85  ?   ?   ?   A . n 
A 1 86  THR 86  86  ?   ?   ?   A . n 
A 1 87  GLU 87  87  87  GLU GLU A . n 
A 1 88  GLN 88  88  88  GLN GLN A . n 
A 1 89  GLU 89  89  89  GLU GLU A . n 
A 1 90  ASP 90  90  90  ASP ASP A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  ALA 93  93  93  ALA ALA A . n 
A 1 94  LYS 94  94  94  LYS LYS A . n 
A 1 95  GLU 95  95  95  GLU GLU A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  GLU 97  97  97  GLU GLU A . n 
A 1 98  ASP 98  98  98  ASP ASP A . n 
A 1 99  VAL 99  99  99  VAL VAL A . n 
A 1 100 ASN 100 100 100 ASN ASN A . n 
A 1 101 LYS 101 101 101 LYS LYS A . n 
A 1 102 TRP 102 102 102 TRP TRP A . n 
A 1 103 GLY 103 103 103 GLY GLY A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 HIS 105 105 105 HIS HIS A . n 
A 1 106 VAL 106 106 106 VAL VAL A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 ARG 108 108 108 ARG ARG A . n 
A 1 109 ILE 109 109 109 ILE ILE A . n 
A 1 110 ALA 110 110 110 ALA ALA A . n 
A 1 111 GLU 111 111 111 GLU GLU A . n 
A 1 112 LEU 112 112 112 LEU LEU A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 GLY 114 114 114 GLY GLY A . n 
A 1 115 ASN 115 115 115 ASN ASN A . n 
A 1 116 ARG 116 116 116 ARG ARG A . n 
A 1 117 PRO 117 117 117 PRO PRO A . n 
A 1 118 LEU 118 118 118 LEU LEU A . n 
A 1 119 THR 119 119 119 THR THR A . n 
A 1 120 VAL 120 120 120 VAL VAL A . n 
A 1 121 ILE 121 121 121 ILE ILE A . n 
A 1 122 MET 122 122 122 MET MET A . n 
A 1 123 HIS 123 123 123 HIS HIS A . n 
A 1 124 THR 124 124 124 THR THR A . n 
A 1 125 ILE 125 125 125 ILE ILE A . n 
A 1 126 PHE 126 126 126 PHE PHE A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 GLU 128 128 128 GLU GLU A . n 
A 1 129 ARG 129 129 129 ARG ARG A . n 
A 1 130 ASP 130 130 130 ASP ASP A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 LYS 133 133 133 LYS LYS A . n 
A 1 134 THR 134 134 134 THR THR A . n 
A 1 135 PHE 135 135 135 PHE PHE A . n 
A 1 136 LYS 136 136 136 LYS LYS A . n 
A 1 137 ILE 137 137 137 ILE ILE A . n 
A 1 138 PRO 138 138 138 PRO PRO A . n 
A 1 139 VAL 139 139 139 VAL VAL A . n 
A 1 140 ASP 140 140 140 ASP ASP A . n 
A 1 141 THR 141 141 141 THR THR A . n 
A 1 142 LEU 142 142 142 LEU LEU A . n 
A 1 143 ILE 143 143 143 ILE ILE A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 TYR 145 145 145 TYR TYR A . n 
A 1 146 LEU 146 146 146 LEU LEU A . n 
A 1 147 MET 147 147 147 MET MET A . n 
A 1 148 THR 148 148 148 THR THR A . n 
A 1 149 LEU 149 149 149 LEU LEU A . n 
A 1 150 GLU 150 150 150 GLU GLU A . n 
A 1 151 ASP 151 151 151 ASP ASP A . n 
A 1 152 HIS 152 152 152 HIS HIS A . n 
A 1 153 TYR 153 153 153 TYR TYR A . n 
A 1 154 HIS 154 154 154 HIS HIS A . n 
A 1 155 ALA 155 155 155 ALA ALA A . n 
A 1 156 ASP 156 156 156 ASP ASP A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 ALA 158 158 158 ALA ALA A . n 
A 1 159 TYR 159 159 159 TYR TYR A . n 
A 1 160 HIS 160 160 160 HIS HIS A . n 
A 1 161 ASN 161 161 161 ASN ASN A . n 
A 1 162 ASN 162 162 162 ASN ASN A . n 
A 1 163 ILE 163 163 163 ILE ILE A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 ALA 165 165 165 ALA ALA A . n 
A 1 166 ALA 166 166 166 ALA ALA A . n 
A 1 167 ASP 167 167 167 ASP ASP A . n 
A 1 168 VAL 168 168 168 VAL VAL A . n 
A 1 169 VAL 169 169 169 VAL VAL A . n 
A 1 170 GLN 170 170 170 GLN GLN A . n 
A 1 171 SER 171 171 171 SER SER A . n 
A 1 172 THR 172 172 172 THR THR A . n 
A 1 173 HIS 173 173 173 HIS HIS A . n 
A 1 174 VAL 174 174 174 VAL VAL A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 LEU 176 176 176 LEU LEU A . n 
A 1 177 SER 177 177 177 SER SER A . n 
A 1 178 THR 178 178 178 THR THR A . n 
A 1 179 PRO 179 179 179 PRO PRO A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 LEU 181 181 181 LEU LEU A . n 
A 1 182 GLU 182 182 182 GLU GLU A . n 
A 1 183 ALA 183 183 183 ALA ALA A . n 
A 1 184 VAL 184 184 184 VAL VAL A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 THR 186 186 186 THR THR A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 GLU 189 189 189 GLU GLU A . n 
A 1 190 ILE 190 190 190 ILE ILE A . n 
A 1 191 LEU 191 191 191 LEU LEU A . n 
A 1 192 ALA 192 192 192 ALA ALA A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 PHE 195 195 195 PHE PHE A . n 
A 1 196 ALA 196 196 196 ALA ALA A . n 
A 1 197 SER 197 197 197 SER SER A . n 
A 1 198 ALA 198 198 198 ALA ALA A . n 
A 1 199 ILE 199 199 199 ILE ILE A . n 
A 1 200 HIS 200 200 200 HIS HIS A . n 
A 1 201 ASP 201 201 201 ASP ASP A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASP 203 203 203 ASP ASP A . n 
A 1 204 HIS 204 204 204 HIS HIS A . n 
A 1 205 PRO 205 205 205 PRO PRO A . n 
A 1 206 GLY 206 206 206 GLY GLY A . n 
A 1 207 VAL 207 207 207 VAL VAL A . n 
A 1 208 SER 208 208 208 SER SER A . n 
A 1 209 ASN 209 209 209 ASN ASN A . n 
A 1 210 GLN 210 210 210 GLN GLN A . n 
A 1 211 PHE 211 211 211 PHE PHE A . n 
A 1 212 LEU 212 212 212 LEU LEU A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 THR 215 215 215 THR THR A . n 
A 1 216 ASN 216 216 216 ASN ASN A . n 
A 1 217 SER 217 217 217 SER SER A . n 
A 1 218 GLU 218 218 218 GLU GLU A . n 
A 1 219 LEU 219 219 219 LEU LEU A . n 
A 1 220 ALA 220 220 220 ALA ALA A . n 
A 1 221 LEU 221 221 221 LEU LEU A . n 
A 1 222 MET 222 222 222 MET MET A . n 
A 1 223 TYR 223 223 223 TYR TYR A . n 
A 1 224 ASN 224 224 224 ASN ASN A . n 
A 1 225 ASP 225 225 225 ASP ASP A . n 
A 1 226 SER 226 226 226 SER SER A . n 
A 1 227 SER 227 227 227 SER SER A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 LEU 229 229 229 LEU LEU A . n 
A 1 230 GLU 230 230 230 GLU GLU A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 HIS 232 232 232 HIS HIS A . n 
A 1 233 HIS 233 233 233 HIS HIS A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 ALA 235 235 235 ALA ALA A . n 
A 1 236 VAL 236 236 236 VAL VAL A . n 
A 1 237 GLY 237 237 237 GLY GLY A . n 
A 1 238 PHE 238 238 238 PHE PHE A . n 
A 1 239 LYS 239 239 239 LYS LYS A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 LEU 241 241 241 LEU LEU A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 GLU 243 243 243 GLU GLU A . n 
A 1 244 GLU 244 244 244 GLU GLU A . n 
A 1 245 ASN 245 245 245 ASN ASN A . n 
A 1 246 CYS 246 246 246 CYS CYS A . n 
A 1 247 ASP 247 247 247 ASP ASP A . n 
A 1 248 ILE 248 248 248 ILE ILE A . n 
A 1 249 PHE 249 249 249 PHE PHE A . n 
A 1 250 GLN 250 250 250 GLN GLN A . n 
A 1 251 ASN 251 251 251 ASN ASN A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 THR 253 253 253 THR THR A . n 
A 1 254 LYS 254 254 254 LYS LYS A . n 
A 1 255 LYS 255 255 255 LYS LYS A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 ARG 257 257 257 ARG ARG A . n 
A 1 258 GLN 258 258 258 GLN GLN A . n 
A 1 259 SER 259 259 259 SER SER A . n 
A 1 260 LEU 260 260 260 LEU LEU A . n 
A 1 261 ARG 261 261 261 ARG ARG A . n 
A 1 262 LYS 262 262 262 LYS LYS A . n 
A 1 263 MET 263 263 263 MET MET A . n 
A 1 264 VAL 264 264 264 VAL VAL A . n 
A 1 265 ILE 265 265 265 ILE ILE A . n 
A 1 266 ASP 266 266 266 ASP ASP A . n 
A 1 267 ILE 267 267 267 ILE ILE A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 LEU 269 269 269 LEU LEU A . n 
A 1 270 ALA 270 270 270 ALA ALA A . n 
A 1 271 THR 271 271 271 THR THR A . n 
A 1 272 ASP 272 272 272 ASP ASP A . n 
A 1 273 MET 273 273 273 MET MET A . n 
A 1 274 SER 274 274 274 SER SER A . n 
A 1 275 LYS 275 275 275 LYS LYS A . n 
A 1 276 HIS 276 276 276 HIS HIS A . n 
A 1 277 MET 277 277 277 MET MET A . n 
A 1 278 ASN 278 278 278 ASN ASN A . n 
A 1 279 LEU 279 279 279 LEU LEU A . n 
A 1 280 LEU 280 280 280 LEU LEU A . n 
A 1 281 ALA 281 281 281 ALA ALA A . n 
A 1 282 ASP 282 282 282 ASP ASP A . n 
A 1 283 LEU 283 283 283 LEU LEU A . n 
A 1 284 LYS 284 284 284 LYS LYS A . n 
A 1 285 THR 285 285 285 THR THR A . n 
A 1 286 MET 286 286 286 MET MET A . n 
A 1 287 VAL 287 287 287 VAL VAL A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 THR 289 289 289 THR THR A . n 
A 1 290 LYS 290 290 290 LYS LYS A . n 
A 1 291 LYS 291 291 291 LYS LYS A . n 
A 1 292 VAL 292 292 292 VAL VAL A . n 
A 1 293 THR 293 293 293 THR THR A . n 
A 1 294 SER 294 294 294 SER SER A . n 
A 1 295 SER 295 295 295 SER SER A . n 
A 1 296 GLY 296 296 296 GLY GLY A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 LEU 300 300 300 LEU LEU A . n 
A 1 301 ASP 301 301 301 ASP ASP A . n 
A 1 302 ASN 302 302 302 ASN ASN A . n 
A 1 303 TYR 303 303 303 TYR TYR A . n 
A 1 304 SER 304 304 304 SER SER A . n 
A 1 305 ASP 305 305 305 ASP ASP A . n 
A 1 306 ARG 306 306 306 ARG ARG A . n 
A 1 307 ILE 307 307 307 ILE ILE A . n 
A 1 308 GLN 308 308 308 GLN GLN A . n 
A 1 309 VAL 309 309 309 VAL VAL A . n 
A 1 310 LEU 310 310 310 LEU LEU A . n 
A 1 311 GLN 311 311 311 GLN GLN A . n 
A 1 312 ASN 312 312 312 ASN ASN A . n 
A 1 313 MET 313 313 313 MET MET A . n 
A 1 314 VAL 314 314 314 VAL VAL A . n 
A 1 315 HIS 315 315 315 HIS HIS A . n 
A 1 316 CYS 316 316 316 CYS CYS A . n 
A 1 317 ALA 317 317 317 ALA ALA A . n 
A 1 318 ASP 318 318 318 ASP ASP A . n 
A 1 319 LEU 319 319 319 LEU LEU A . n 
A 1 320 SER 320 320 320 SER SER A . n 
A 1 321 ASN 321 321 321 ASN ASN A . n 
A 1 322 PRO 322 322 322 PRO PRO A . n 
A 1 323 THR 323 323 323 THR THR A . n 
A 1 324 LYS 324 324 324 LYS LYS A . n 
A 1 325 PRO 325 325 325 PRO PRO A . n 
A 1 326 LEU 326 326 326 LEU LEU A . n 
A 1 327 GLN 327 327 327 GLN GLN A . n 
A 1 328 LEU 328 328 328 LEU LEU A . n 
A 1 329 TYR 329 329 329 TYR TYR A . n 
A 1 330 ARG 330 330 330 ARG ARG A . n 
A 1 331 GLN 331 331 331 GLN GLN A . n 
A 1 332 TRP 332 332 332 TRP TRP A . n 
A 1 333 THR 333 333 333 THR THR A . n 
A 1 334 ASP 334 334 334 ASP ASP A . n 
A 1 335 ARG 335 335 335 ARG ARG A . n 
A 1 336 ILE 336 336 336 ILE ILE A . n 
A 1 337 MET 337 337 337 MET MET A . n 
A 1 338 GLU 338 338 338 GLU GLU A . n 
A 1 339 GLU 339 339 339 GLU GLU A . n 
A 1 340 PHE 340 340 340 PHE PHE A . n 
A 1 341 PHE 341 341 341 PHE PHE A . n 
A 1 342 ARG 342 342 342 ARG ARG A . n 
A 1 343 GLN 343 343 343 GLN GLN A . n 
A 1 344 GLY 344 344 344 GLY GLY A . n 
A 1 345 ASP 345 345 345 ASP ASP A . n 
A 1 346 ARG 346 346 346 ARG ARG A . n 
A 1 347 GLU 347 347 347 GLU GLU A . n 
A 1 348 ARG 348 348 348 ARG ARG A . n 
A 1 349 GLU 349 349 349 GLU GLU A . n 
A 1 350 ARG 350 350 350 ARG ARG A . n 
A 1 351 GLY 351 351 351 GLY GLY A . n 
A 1 352 MET 352 352 352 MET MET A . n 
A 1 353 GLU 353 353 353 GLU GLU A . n 
A 1 354 ILE 354 354 354 ILE ILE A . n 
A 1 355 SER 355 355 355 SER SER A . n 
A 1 356 PRO 356 356 356 PRO PRO A . n 
A 1 357 MET 357 357 357 MET MET A . n 
A 1 358 CYS 358 358 358 CYS CYS A . n 
A 1 359 ASP 359 359 359 ASP ASP A . n 
A 1 360 LYS 360 360 360 LYS LYS A . n 
A 1 361 HIS 361 361 361 HIS HIS A . n 
A 1 362 ASN 362 362 362 ASN ASN A . n 
A 1 363 ALA 363 363 363 ALA ALA A . n 
A 1 364 SER 364 364 364 SER SER A . n 
A 1 365 VAL 365 365 365 VAL VAL A . n 
A 1 366 GLU 366 366 366 GLU GLU A . n 
A 1 367 LYS 367 367 367 LYS LYS A . n 
A 1 368 SER 368 368 368 SER SER A . n 
A 1 369 GLN 369 369 369 GLN GLN A . n 
A 1 370 VAL 370 370 370 VAL VAL A . n 
A 1 371 GLY 371 371 371 GLY GLY A . n 
A 1 372 PHE 372 372 372 PHE PHE A . n 
A 1 373 ILE 373 373 373 ILE ILE A . n 
A 1 374 ASP 374 374 374 ASP ASP A . n 
A 1 375 TYR 375 375 375 TYR TYR A . n 
A 1 376 ILE 376 376 376 ILE ILE A . n 
A 1 377 VAL 377 377 377 VAL VAL A . n 
A 1 378 HIS 378 378 378 HIS HIS A . n 
A 1 379 PRO 379 379 379 PRO PRO A . n 
A 1 380 LEU 380 380 380 LEU LEU A . n 
A 1 381 TRP 381 381 381 TRP TRP A . n 
A 1 382 GLU 382 382 382 GLU GLU A . n 
A 1 383 THR 383 383 383 THR THR A . n 
A 1 384 TRP 384 384 384 TRP TRP A . n 
A 1 385 ALA 385 385 385 ALA ALA A . n 
A 1 386 ASP 386 386 386 ASP ASP A . n 
A 1 387 LEU 387 387 387 LEU LEU A . n 
A 1 388 VAL 388 388 388 VAL VAL A . n 
A 1 389 HIS 389 389 389 HIS HIS A . n 
A 1 390 PRO 390 390 390 PRO PRO A . n 
A 1 391 ASP 391 391 391 ASP ASP A . n 
A 1 392 ALA 392 392 392 ALA ALA A . n 
A 1 393 GLN 393 393 393 GLN GLN A . n 
A 1 394 ASP 394 394 394 ASP ASP A . n 
A 1 395 ILE 395 395 395 ILE ILE A . n 
A 1 396 LEU 396 396 396 LEU LEU A . n 
A 1 397 ASP 397 397 397 ASP ASP A . n 
A 1 398 THR 398 398 398 THR THR A . n 
A 1 399 LEU 399 399 399 LEU LEU A . n 
A 1 400 GLU 400 400 400 GLU GLU A . n 
A 1 401 ASP 401 401 401 ASP ASP A . n 
A 1 402 ASN 402 402 402 ASN ASN A . n 
A 1 403 ARG 403 403 403 ARG ARG A . n 
A 1 404 GLU 404 404 404 GLU GLU A . n 
A 1 405 TRP 405 405 405 TRP TRP A . n 
A 1 406 TYR 406 406 406 TYR TYR A . n 
A 1 407 GLN 407 407 407 GLN GLN A . n 
A 1 408 SER 408 408 408 SER SER A . n 
A 1 409 THR 409 409 409 THR THR A . n 
A 1 410 ILE 410 410 410 ILE ILE A . n 
A 1 411 PRO 411 411 ?   ?   ?   A . n 
A 1 412 GLN 412 412 ?   ?   ?   A . n 
A 1 413 SER 413 413 ?   ?   ?   A . n 
A 1 414 PRO 414 414 ?   ?   ?   A . n 
A 1 415 SER 415 415 ?   ?   ?   A . n 
A 1 416 PRO 416 416 ?   ?   ?   A . n 
A 1 417 ALA 417 417 ?   ?   ?   A . n 
A 1 418 PRO 418 418 ?   ?   ?   A . n 
A 1 419 ASP 419 419 ?   ?   ?   A . n 
A 1 420 ASP 420 420 ?   ?   ?   A . n 
A 1 421 PRO 421 421 ?   ?   ?   A . n 
A 1 422 GLU 422 422 ?   ?   ?   A . n 
A 1 423 GLU 423 423 ?   ?   ?   A . n 
A 1 424 GLY 424 424 ?   ?   ?   A . n 
A 1 425 ARG 425 425 ?   ?   ?   A . n 
A 1 426 GLN 426 426 ?   ?   ?   A . n 
A 1 427 GLY 427 427 ?   ?   ?   A . n 
A 1 428 GLN 428 428 ?   ?   ?   A . n 
A 1 429 THR 429 429 ?   ?   ?   A . n 
A 1 430 GLU 430 430 ?   ?   ?   A . n 
A 1 431 LYS 431 431 ?   ?   ?   A . n 
A 1 432 PHE 432 432 ?   ?   ?   A . n 
A 1 433 GLN 433 433 ?   ?   ?   A . n 
A 1 434 PHE 434 434 ?   ?   ?   A . n 
A 1 435 GLU 435 435 ?   ?   ?   A . n 
A 1 436 LEU 436 436 ?   ?   ?   A . n 
A 1 437 THR 437 437 ?   ?   ?   A . n 
A 1 438 LEU 438 438 ?   ?   ?   A . n 
A 1 439 GLU 439 439 ?   ?   ?   A . n 
A 1 440 GLU 440 440 ?   ?   ?   A . n 
A 1 441 ASP 441 441 ?   ?   ?   A . n 
A 1 442 GLY 442 442 ?   ?   ?   A . n 
A 1 443 GLU 443 443 ?   ?   ?   A . n 
A 1 444 SER 444 444 ?   ?   ?   A . n 
A 1 445 ASP 445 445 ?   ?   ?   A . n 
A 1 446 THR 446 446 ?   ?   ?   A . n 
A 1 447 GLU 447 447 ?   ?   ?   A . n 
A 1 448 LYS 448 448 ?   ?   ?   A . n 
A 1 449 ASP 449 449 ?   ?   ?   A . n 
A 1 450 SER 450 450 ?   ?   ?   A . n 
A 1 451 GLY 451 451 ?   ?   ?   A . n 
A 1 452 SER 452 452 ?   ?   ?   A . n 
A 1 453 GLN 453 453 ?   ?   ?   A . n 
A 1 454 VAL 454 454 ?   ?   ?   A . n 
A 1 455 GLU 455 455 ?   ?   ?   A . n 
A 1 456 GLU 456 456 ?   ?   ?   A . n 
A 1 457 ASP 457 457 ?   ?   ?   A . n 
A 1 458 THR 458 458 ?   ?   ?   A . n 
A 1 459 SER 459 459 ?   ?   ?   A . n 
A 1 460 CYS 460 460 ?   ?   ?   A . n 
A 1 461 SER 461 461 ?   ?   ?   A . n 
A 1 462 ASP 462 462 ?   ?   ?   A . n 
A 1 463 SER 463 463 ?   ?   ?   A . n 
A 1 464 LYS 464 464 ?   ?   ?   A . n 
A 1 465 THR 465 465 ?   ?   ?   A . n 
A 1 466 LEU 466 466 ?   ?   ?   A . n 
A 1 467 CYS 467 467 ?   ?   ?   A . n 
A 1 468 THR 468 468 ?   ?   ?   A . n 
A 1 469 GLN 469 469 ?   ?   ?   A . n 
A 1 470 ASP 470 470 ?   ?   ?   A . n 
A 1 471 SER 471 471 ?   ?   ?   A . n 
A 1 472 GLU 472 472 ?   ?   ?   A . n 
A 1 473 SER 473 473 ?   ?   ?   A . n 
A 1 474 THR 474 474 ?   ?   ?   A . n 
A 1 475 GLU 475 475 ?   ?   ?   A . n 
A 1 476 ILE 476 476 ?   ?   ?   A . n 
A 1 477 PRO 477 477 ?   ?   ?   A . n 
A 1 478 LEU 478 478 ?   ?   ?   A . n 
A 1 479 ASP 479 479 ?   ?   ?   A . n 
A 1 480 GLU 480 480 ?   ?   ?   A . n 
A 1 481 GLN 481 481 ?   ?   ?   A . n 
A 1 482 VAL 482 482 ?   ?   ?   A . n 
A 1 483 GLU 483 483 ?   ?   ?   A . n 
A 1 484 GLU 484 484 ?   ?   ?   A . n 
A 1 485 GLU 485 485 ?   ?   ?   A . n 
A 1 486 ALA 486 486 ?   ?   ?   A . n 
A 1 487 VAL 487 487 ?   ?   ?   A . n 
A 1 488 GLY 488 488 ?   ?   ?   A . n 
A 1 489 GLU 489 489 ?   ?   ?   A . n 
A 1 490 GLU 490 490 ?   ?   ?   A . n 
A 1 491 GLU 491 491 ?   ?   ?   A . n 
A 1 492 GLU 492 492 ?   ?   ?   A . n 
A 1 493 SER 493 493 ?   ?   ?   A . n 
A 1 494 GLN 494 494 ?   ?   ?   A . n 
A 1 495 PRO 495 495 ?   ?   ?   A . n 
A 1 496 GLU 496 496 ?   ?   ?   A . n 
A 1 497 ALA 497 497 ?   ?   ?   A . n 
A 1 498 CYS 498 498 ?   ?   ?   A . n 
A 1 499 VAL 499 499 ?   ?   ?   A . n 
A 1 500 ILE 500 500 ?   ?   ?   A . n 
A 1 501 ASP 501 501 ?   ?   ?   A . n 
A 1 502 ASP 502 502 ?   ?   ?   A . n 
A 1 503 ARG 503 503 ?   ?   ?   A . n 
A 1 504 SER 504 504 ?   ?   ?   A . n 
A 1 505 PRO 505 505 ?   ?   ?   A . n 
A 1 506 ASP 506 506 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   ALA 2   2   ?   ?   ?   B . n 
B 1 3   SER 3   3   ?   ?   ?   B . n 
B 1 4   ASN 4   4   ?   ?   ?   B . n 
B 1 5   LYS 5   5   ?   ?   ?   B . n 
B 1 6   PHE 6   6   ?   ?   ?   B . n 
B 1 7   LYS 7   7   ?   ?   ?   B . n 
B 1 8   ARG 8   8   ?   ?   ?   B . n 
B 1 9   MET 9   9   ?   ?   ?   B . n 
B 1 10  LEU 10  10  ?   ?   ?   B . n 
B 1 11  ASN 11  11  ?   ?   ?   B . n 
B 1 12  ARG 12  12  ?   ?   ?   B . n 
B 1 13  GLU 13  13  ?   ?   ?   B . n 
B 1 14  LEU 14  14  ?   ?   ?   B . n 
B 1 15  THR 15  15  ?   ?   ?   B . n 
B 1 16  HIS 16  16  ?   ?   ?   B . n 
B 1 17  LEU 17  17  ?   ?   ?   B . n 
B 1 18  SER 18  18  ?   ?   ?   B . n 
B 1 19  GLU 19  19  ?   ?   ?   B . n 
B 1 20  MET 20  20  ?   ?   ?   B . n 
B 1 21  SER 21  21  ?   ?   ?   B . n 
B 1 22  ARG 22  22  ?   ?   ?   B . n 
B 1 23  SER 23  23  ?   ?   ?   B . n 
B 1 24  GLY 24  24  ?   ?   ?   B . n 
B 1 25  ASN 25  25  ?   ?   ?   B . n 
B 1 26  GLN 26  26  ?   ?   ?   B . n 
B 1 27  VAL 27  27  ?   ?   ?   B . n 
B 1 28  SER 28  28  ?   ?   ?   B . n 
B 1 29  GLU 29  29  ?   ?   ?   B . n 
B 1 30  PHE 30  30  ?   ?   ?   B . n 
B 1 31  ILE 31  31  ?   ?   ?   B . n 
B 1 32  SER 32  32  ?   ?   ?   B . n 
B 1 33  ASN 33  33  ?   ?   ?   B . n 
B 1 34  THR 34  34  ?   ?   ?   B . n 
B 1 35  PHE 35  35  ?   ?   ?   B . n 
B 1 36  LEU 36  36  ?   ?   ?   B . n 
B 1 37  ASP 37  37  ?   ?   ?   B . n 
B 1 38  LYS 38  38  ?   ?   ?   B . n 
B 1 39  GLN 39  39  ?   ?   ?   B . n 
B 1 40  HIS 40  40  ?   ?   ?   B . n 
B 1 41  GLU 41  41  ?   ?   ?   B . n 
B 1 42  VAL 42  42  ?   ?   ?   B . n 
B 1 43  GLU 43  43  ?   ?   ?   B . n 
B 1 44  ILE 44  44  ?   ?   ?   B . n 
B 1 45  PRO 45  45  ?   ?   ?   B . n 
B 1 46  SER 46  46  ?   ?   ?   B . n 
B 1 47  PRO 47  47  ?   ?   ?   B . n 
B 1 48  THR 48  48  ?   ?   ?   B . n 
B 1 49  GLN 49  49  ?   ?   ?   B . n 
B 1 50  LYS 50  50  ?   ?   ?   B . n 
B 1 51  GLU 51  51  ?   ?   ?   B . n 
B 1 52  LYS 52  52  ?   ?   ?   B . n 
B 1 53  GLU 53  53  ?   ?   ?   B . n 
B 1 54  LYS 54  54  ?   ?   ?   B . n 
B 1 55  LYS 55  55  ?   ?   ?   B . n 
B 1 56  LYS 56  56  ?   ?   ?   B . n 
B 1 57  ARG 57  57  ?   ?   ?   B . n 
B 1 58  PRO 58  58  ?   ?   ?   B . n 
B 1 59  MET 59  59  ?   ?   ?   B . n 
B 1 60  SER 60  60  ?   ?   ?   B . n 
B 1 61  GLN 61  61  ?   ?   ?   B . n 
B 1 62  ILE 62  62  ?   ?   ?   B . n 
B 1 63  SER 63  63  ?   ?   ?   B . n 
B 1 64  GLY 64  64  ?   ?   ?   B . n 
B 1 65  VAL 65  65  ?   ?   ?   B . n 
B 1 66  LYS 66  66  ?   ?   ?   B . n 
B 1 67  LYS 67  67  ?   ?   ?   B . n 
B 1 68  LEU 68  68  ?   ?   ?   B . n 
B 1 69  MET 69  69  ?   ?   ?   B . n 
B 1 70  HIS 70  70  ?   ?   ?   B . n 
B 1 71  SER 71  71  ?   ?   ?   B . n 
B 1 72  SER 72  72  ?   ?   ?   B . n 
B 1 73  SER 73  73  ?   ?   ?   B . n 
B 1 74  LEU 74  74  ?   ?   ?   B . n 
B 1 75  THR 75  75  ?   ?   ?   B . n 
B 1 76  ASN 76  76  ?   ?   ?   B . n 
B 1 77  SER 77  77  ?   ?   ?   B . n 
B 1 78  SER 78  78  ?   ?   ?   B . n 
B 1 79  ILE 79  79  ?   ?   ?   B . n 
B 1 80  PRO 80  80  ?   ?   ?   B . n 
B 1 81  ARG 81  81  ?   ?   ?   B . n 
B 1 82  PHE 82  82  ?   ?   ?   B . n 
B 1 83  GLY 83  83  ?   ?   ?   B . n 
B 1 84  VAL 84  84  ?   ?   ?   B . n 
B 1 85  LYS 85  85  ?   ?   ?   B . n 
B 1 86  THR 86  86  ?   ?   ?   B . n 
B 1 87  GLU 87  87  87  GLU GLU B . n 
B 1 88  GLN 88  88  88  GLN GLN B . n 
B 1 89  GLU 89  89  89  GLU GLU B . n 
B 1 90  ASP 90  90  90  ASP ASP B . n 
B 1 91  VAL 91  91  91  VAL VAL B . n 
B 1 92  LEU 92  92  92  LEU LEU B . n 
B 1 93  ALA 93  93  93  ALA ALA B . n 
B 1 94  LYS 94  94  94  LYS LYS B . n 
B 1 95  GLU 95  95  95  GLU GLU B . n 
B 1 96  LEU 96  96  96  LEU LEU B . n 
B 1 97  GLU 97  97  97  GLU GLU B . n 
B 1 98  ASP 98  98  98  ASP ASP B . n 
B 1 99  VAL 99  99  99  VAL VAL B . n 
B 1 100 ASN 100 100 100 ASN ASN B . n 
B 1 101 LYS 101 101 101 LYS LYS B . n 
B 1 102 TRP 102 102 102 TRP TRP B . n 
B 1 103 GLY 103 103 103 GLY GLY B . n 
B 1 104 LEU 104 104 104 LEU LEU B . n 
B 1 105 HIS 105 105 105 HIS HIS B . n 
B 1 106 VAL 106 106 106 VAL VAL B . n 
B 1 107 PHE 107 107 107 PHE PHE B . n 
B 1 108 ARG 108 108 108 ARG ARG B . n 
B 1 109 ILE 109 109 109 ILE ILE B . n 
B 1 110 ALA 110 110 110 ALA ALA B . n 
B 1 111 GLU 111 111 111 GLU GLU B . n 
B 1 112 LEU 112 112 112 LEU LEU B . n 
B 1 113 SER 113 113 113 SER SER B . n 
B 1 114 GLY 114 114 114 GLY GLY B . n 
B 1 115 ASN 115 115 115 ASN ASN B . n 
B 1 116 ARG 116 116 116 ARG ARG B . n 
B 1 117 PRO 117 117 117 PRO PRO B . n 
B 1 118 LEU 118 118 118 LEU LEU B . n 
B 1 119 THR 119 119 119 THR THR B . n 
B 1 120 VAL 120 120 120 VAL VAL B . n 
B 1 121 ILE 121 121 121 ILE ILE B . n 
B 1 122 MET 122 122 122 MET MET B . n 
B 1 123 HIS 123 123 123 HIS HIS B . n 
B 1 124 THR 124 124 124 THR THR B . n 
B 1 125 ILE 125 125 125 ILE ILE B . n 
B 1 126 PHE 126 126 126 PHE PHE B . n 
B 1 127 GLN 127 127 127 GLN GLN B . n 
B 1 128 GLU 128 128 128 GLU GLU B . n 
B 1 129 ARG 129 129 129 ARG ARG B . n 
B 1 130 ASP 130 130 130 ASP ASP B . n 
B 1 131 LEU 131 131 131 LEU LEU B . n 
B 1 132 LEU 132 132 132 LEU LEU B . n 
B 1 133 LYS 133 133 133 LYS LYS B . n 
B 1 134 THR 134 134 134 THR THR B . n 
B 1 135 PHE 135 135 135 PHE PHE B . n 
B 1 136 LYS 136 136 136 LYS LYS B . n 
B 1 137 ILE 137 137 137 ILE ILE B . n 
B 1 138 PRO 138 138 138 PRO PRO B . n 
B 1 139 VAL 139 139 139 VAL VAL B . n 
B 1 140 ASP 140 140 140 ASP ASP B . n 
B 1 141 THR 141 141 141 THR THR B . n 
B 1 142 LEU 142 142 142 LEU LEU B . n 
B 1 143 ILE 143 143 143 ILE ILE B . n 
B 1 144 THR 144 144 144 THR THR B . n 
B 1 145 TYR 145 145 145 TYR TYR B . n 
B 1 146 LEU 146 146 146 LEU LEU B . n 
B 1 147 MET 147 147 147 MET MET B . n 
B 1 148 THR 148 148 148 THR THR B . n 
B 1 149 LEU 149 149 149 LEU LEU B . n 
B 1 150 GLU 150 150 150 GLU GLU B . n 
B 1 151 ASP 151 151 151 ASP ASP B . n 
B 1 152 HIS 152 152 152 HIS HIS B . n 
B 1 153 TYR 153 153 153 TYR TYR B . n 
B 1 154 HIS 154 154 154 HIS HIS B . n 
B 1 155 ALA 155 155 155 ALA ALA B . n 
B 1 156 ASP 156 156 156 ASP ASP B . n 
B 1 157 VAL 157 157 157 VAL VAL B . n 
B 1 158 ALA 158 158 158 ALA ALA B . n 
B 1 159 TYR 159 159 159 TYR TYR B . n 
B 1 160 HIS 160 160 160 HIS HIS B . n 
B 1 161 ASN 161 161 161 ASN ASN B . n 
B 1 162 ASN 162 162 162 ASN ASN B . n 
B 1 163 ILE 163 163 163 ILE ILE B . n 
B 1 164 HIS 164 164 164 HIS HIS B . n 
B 1 165 ALA 165 165 165 ALA ALA B . n 
B 1 166 ALA 166 166 166 ALA ALA B . n 
B 1 167 ASP 167 167 167 ASP ASP B . n 
B 1 168 VAL 168 168 168 VAL VAL B . n 
B 1 169 VAL 169 169 169 VAL VAL B . n 
B 1 170 GLN 170 170 170 GLN GLN B . n 
B 1 171 SER 171 171 171 SER SER B . n 
B 1 172 THR 172 172 172 THR THR B . n 
B 1 173 HIS 173 173 173 HIS HIS B . n 
B 1 174 VAL 174 174 174 VAL VAL B . n 
B 1 175 LEU 175 175 175 LEU LEU B . n 
B 1 176 LEU 176 176 176 LEU LEU B . n 
B 1 177 SER 177 177 177 SER SER B . n 
B 1 178 THR 178 178 178 THR THR B . n 
B 1 179 PRO 179 179 179 PRO PRO B . n 
B 1 180 ALA 180 180 180 ALA ALA B . n 
B 1 181 LEU 181 181 181 LEU LEU B . n 
B 1 182 GLU 182 182 182 GLU GLU B . n 
B 1 183 ALA 183 183 183 ALA ALA B . n 
B 1 184 VAL 184 184 184 VAL VAL B . n 
B 1 185 PHE 185 185 185 PHE PHE B . n 
B 1 186 THR 186 186 186 THR THR B . n 
B 1 187 ASP 187 187 187 ASP ASP B . n 
B 1 188 LEU 188 188 188 LEU LEU B . n 
B 1 189 GLU 189 189 189 GLU GLU B . n 
B 1 190 ILE 190 190 190 ILE ILE B . n 
B 1 191 LEU 191 191 191 LEU LEU B . n 
B 1 192 ALA 192 192 192 ALA ALA B . n 
B 1 193 ALA 193 193 193 ALA ALA B . n 
B 1 194 ILE 194 194 194 ILE ILE B . n 
B 1 195 PHE 195 195 195 PHE PHE B . n 
B 1 196 ALA 196 196 196 ALA ALA B . n 
B 1 197 SER 197 197 197 SER SER B . n 
B 1 198 ALA 198 198 198 ALA ALA B . n 
B 1 199 ILE 199 199 199 ILE ILE B . n 
B 1 200 HIS 200 200 200 HIS HIS B . n 
B 1 201 ASP 201 201 201 ASP ASP B . n 
B 1 202 VAL 202 202 202 VAL VAL B . n 
B 1 203 ASP 203 203 203 ASP ASP B . n 
B 1 204 HIS 204 204 204 HIS HIS B . n 
B 1 205 PRO 205 205 205 PRO PRO B . n 
B 1 206 GLY 206 206 206 GLY GLY B . n 
B 1 207 VAL 207 207 207 VAL VAL B . n 
B 1 208 SER 208 208 208 SER SER B . n 
B 1 209 ASN 209 209 209 ASN ASN B . n 
B 1 210 GLN 210 210 210 GLN GLN B . n 
B 1 211 PHE 211 211 211 PHE PHE B . n 
B 1 212 LEU 212 212 212 LEU LEU B . n 
B 1 213 ILE 213 213 213 ILE ILE B . n 
B 1 214 ASN 214 214 214 ASN ASN B . n 
B 1 215 THR 215 215 215 THR THR B . n 
B 1 216 ASN 216 216 216 ASN ASN B . n 
B 1 217 SER 217 217 217 SER SER B . n 
B 1 218 GLU 218 218 218 GLU GLU B . n 
B 1 219 LEU 219 219 219 LEU LEU B . n 
B 1 220 ALA 220 220 220 ALA ALA B . n 
B 1 221 LEU 221 221 221 LEU LEU B . n 
B 1 222 MET 222 222 222 MET MET B . n 
B 1 223 TYR 223 223 223 TYR TYR B . n 
B 1 224 ASN 224 224 224 ASN ASN B . n 
B 1 225 ASP 225 225 225 ASP ASP B . n 
B 1 226 SER 226 226 226 SER SER B . n 
B 1 227 SER 227 227 227 SER SER B . n 
B 1 228 VAL 228 228 228 VAL VAL B . n 
B 1 229 LEU 229 229 229 LEU LEU B . n 
B 1 230 GLU 230 230 230 GLU GLU B . n 
B 1 231 ASN 231 231 231 ASN ASN B . n 
B 1 232 HIS 232 232 232 HIS HIS B . n 
B 1 233 HIS 233 233 233 HIS HIS B . n 
B 1 234 LEU 234 234 234 LEU LEU B . n 
B 1 235 ALA 235 235 235 ALA ALA B . n 
B 1 236 VAL 236 236 236 VAL VAL B . n 
B 1 237 GLY 237 237 237 GLY GLY B . n 
B 1 238 PHE 238 238 238 PHE PHE B . n 
B 1 239 LYS 239 239 239 LYS LYS B . n 
B 1 240 LEU 240 240 240 LEU LEU B . n 
B 1 241 LEU 241 241 241 LEU LEU B . n 
B 1 242 GLN 242 242 242 GLN GLN B . n 
B 1 243 GLU 243 243 243 GLU GLU B . n 
B 1 244 GLU 244 244 244 GLU GLU B . n 
B 1 245 ASN 245 245 245 ASN ASN B . n 
B 1 246 CYS 246 246 246 CYS CYS B . n 
B 1 247 ASP 247 247 247 ASP ASP B . n 
B 1 248 ILE 248 248 248 ILE ILE B . n 
B 1 249 PHE 249 249 249 PHE PHE B . n 
B 1 250 GLN 250 250 250 GLN GLN B . n 
B 1 251 ASN 251 251 251 ASN ASN B . n 
B 1 252 LEU 252 252 252 LEU LEU B . n 
B 1 253 THR 253 253 253 THR THR B . n 
B 1 254 LYS 254 254 254 LYS LYS B . n 
B 1 255 LYS 255 255 255 LYS LYS B . n 
B 1 256 GLN 256 256 256 GLN GLN B . n 
B 1 257 ARG 257 257 257 ARG ARG B . n 
B 1 258 GLN 258 258 258 GLN GLN B . n 
B 1 259 SER 259 259 259 SER SER B . n 
B 1 260 LEU 260 260 260 LEU LEU B . n 
B 1 261 ARG 261 261 261 ARG ARG B . n 
B 1 262 LYS 262 262 262 LYS LYS B . n 
B 1 263 MET 263 263 263 MET MET B . n 
B 1 264 VAL 264 264 264 VAL VAL B . n 
B 1 265 ILE 265 265 265 ILE ILE B . n 
B 1 266 ASP 266 266 266 ASP ASP B . n 
B 1 267 ILE 267 267 267 ILE ILE B . n 
B 1 268 VAL 268 268 268 VAL VAL B . n 
B 1 269 LEU 269 269 269 LEU LEU B . n 
B 1 270 ALA 270 270 270 ALA ALA B . n 
B 1 271 THR 271 271 271 THR THR B . n 
B 1 272 ASP 272 272 272 ASP ASP B . n 
B 1 273 MET 273 273 273 MET MET B . n 
B 1 274 SER 274 274 274 SER SER B . n 
B 1 275 LYS 275 275 275 LYS LYS B . n 
B 1 276 HIS 276 276 276 HIS HIS B . n 
B 1 277 MET 277 277 277 MET MET B . n 
B 1 278 ASN 278 278 278 ASN ASN B . n 
B 1 279 LEU 279 279 279 LEU LEU B . n 
B 1 280 LEU 280 280 280 LEU LEU B . n 
B 1 281 ALA 281 281 281 ALA ALA B . n 
B 1 282 ASP 282 282 282 ASP ASP B . n 
B 1 283 LEU 283 283 283 LEU LEU B . n 
B 1 284 LYS 284 284 284 LYS LYS B . n 
B 1 285 THR 285 285 285 THR THR B . n 
B 1 286 MET 286 286 286 MET MET B . n 
B 1 287 VAL 287 287 287 VAL VAL B . n 
B 1 288 GLU 288 288 288 GLU GLU B . n 
B 1 289 THR 289 289 289 THR THR B . n 
B 1 290 LYS 290 290 290 LYS LYS B . n 
B 1 291 LYS 291 291 291 LYS LYS B . n 
B 1 292 VAL 292 292 292 VAL VAL B . n 
B 1 293 THR 293 293 293 THR THR B . n 
B 1 294 SER 294 294 294 SER SER B . n 
B 1 295 SER 295 295 295 SER SER B . n 
B 1 296 GLY 296 296 296 GLY GLY B . n 
B 1 297 VAL 297 297 297 VAL VAL B . n 
B 1 298 LEU 298 298 298 LEU LEU B . n 
B 1 299 LEU 299 299 299 LEU LEU B . n 
B 1 300 LEU 300 300 300 LEU LEU B . n 
B 1 301 ASP 301 301 301 ASP ASP B . n 
B 1 302 ASN 302 302 302 ASN ASN B . n 
B 1 303 TYR 303 303 303 TYR TYR B . n 
B 1 304 SER 304 304 304 SER SER B . n 
B 1 305 ASP 305 305 305 ASP ASP B . n 
B 1 306 ARG 306 306 306 ARG ARG B . n 
B 1 307 ILE 307 307 307 ILE ILE B . n 
B 1 308 GLN 308 308 308 GLN GLN B . n 
B 1 309 VAL 309 309 309 VAL VAL B . n 
B 1 310 LEU 310 310 310 LEU LEU B . n 
B 1 311 GLN 311 311 311 GLN GLN B . n 
B 1 312 ASN 312 312 312 ASN ASN B . n 
B 1 313 MET 313 313 313 MET MET B . n 
B 1 314 VAL 314 314 314 VAL VAL B . n 
B 1 315 HIS 315 315 315 HIS HIS B . n 
B 1 316 CYS 316 316 316 CYS CYS B . n 
B 1 317 ALA 317 317 317 ALA ALA B . n 
B 1 318 ASP 318 318 318 ASP ASP B . n 
B 1 319 LEU 319 319 319 LEU LEU B . n 
B 1 320 SER 320 320 320 SER SER B . n 
B 1 321 ASN 321 321 321 ASN ASN B . n 
B 1 322 PRO 322 322 322 PRO PRO B . n 
B 1 323 THR 323 323 323 THR THR B . n 
B 1 324 LYS 324 324 324 LYS LYS B . n 
B 1 325 PRO 325 325 325 PRO PRO B . n 
B 1 326 LEU 326 326 326 LEU LEU B . n 
B 1 327 GLN 327 327 327 GLN GLN B . n 
B 1 328 LEU 328 328 328 LEU LEU B . n 
B 1 329 TYR 329 329 329 TYR TYR B . n 
B 1 330 ARG 330 330 330 ARG ARG B . n 
B 1 331 GLN 331 331 331 GLN GLN B . n 
B 1 332 TRP 332 332 332 TRP TRP B . n 
B 1 333 THR 333 333 333 THR THR B . n 
B 1 334 ASP 334 334 334 ASP ASP B . n 
B 1 335 ARG 335 335 335 ARG ARG B . n 
B 1 336 ILE 336 336 336 ILE ILE B . n 
B 1 337 MET 337 337 337 MET MET B . n 
B 1 338 GLU 338 338 338 GLU GLU B . n 
B 1 339 GLU 339 339 339 GLU GLU B . n 
B 1 340 PHE 340 340 340 PHE PHE B . n 
B 1 341 PHE 341 341 341 PHE PHE B . n 
B 1 342 ARG 342 342 342 ARG ARG B . n 
B 1 343 GLN 343 343 343 GLN GLN B . n 
B 1 344 GLY 344 344 344 GLY GLY B . n 
B 1 345 ASP 345 345 345 ASP ASP B . n 
B 1 346 ARG 346 346 346 ARG ARG B . n 
B 1 347 GLU 347 347 347 GLU GLU B . n 
B 1 348 ARG 348 348 348 ARG ARG B . n 
B 1 349 GLU 349 349 349 GLU GLU B . n 
B 1 350 ARG 350 350 350 ARG ARG B . n 
B 1 351 GLY 351 351 351 GLY GLY B . n 
B 1 352 MET 352 352 352 MET MET B . n 
B 1 353 GLU 353 353 353 GLU GLU B . n 
B 1 354 ILE 354 354 354 ILE ILE B . n 
B 1 355 SER 355 355 355 SER SER B . n 
B 1 356 PRO 356 356 356 PRO PRO B . n 
B 1 357 MET 357 357 357 MET MET B . n 
B 1 358 CYS 358 358 358 CYS CYS B . n 
B 1 359 ASP 359 359 359 ASP ASP B . n 
B 1 360 LYS 360 360 360 LYS LYS B . n 
B 1 361 HIS 361 361 361 HIS HIS B . n 
B 1 362 ASN 362 362 362 ASN ASN B . n 
B 1 363 ALA 363 363 363 ALA ALA B . n 
B 1 364 SER 364 364 364 SER SER B . n 
B 1 365 VAL 365 365 365 VAL VAL B . n 
B 1 366 GLU 366 366 366 GLU GLU B . n 
B 1 367 LYS 367 367 367 LYS LYS B . n 
B 1 368 SER 368 368 368 SER SER B . n 
B 1 369 GLN 369 369 369 GLN GLN B . n 
B 1 370 VAL 370 370 370 VAL VAL B . n 
B 1 371 GLY 371 371 371 GLY GLY B . n 
B 1 372 PHE 372 372 372 PHE PHE B . n 
B 1 373 ILE 373 373 373 ILE ILE B . n 
B 1 374 ASP 374 374 374 ASP ASP B . n 
B 1 375 TYR 375 375 375 TYR TYR B . n 
B 1 376 ILE 376 376 376 ILE ILE B . n 
B 1 377 VAL 377 377 377 VAL VAL B . n 
B 1 378 HIS 378 378 378 HIS HIS B . n 
B 1 379 PRO 379 379 379 PRO PRO B . n 
B 1 380 LEU 380 380 380 LEU LEU B . n 
B 1 381 TRP 381 381 381 TRP TRP B . n 
B 1 382 GLU 382 382 382 GLU GLU B . n 
B 1 383 THR 383 383 383 THR THR B . n 
B 1 384 TRP 384 384 384 TRP TRP B . n 
B 1 385 ALA 385 385 385 ALA ALA B . n 
B 1 386 ASP 386 386 386 ASP ASP B . n 
B 1 387 LEU 387 387 387 LEU LEU B . n 
B 1 388 VAL 388 388 388 VAL VAL B . n 
B 1 389 HIS 389 389 389 HIS HIS B . n 
B 1 390 PRO 390 390 390 PRO PRO B . n 
B 1 391 ASP 391 391 391 ASP ASP B . n 
B 1 392 ALA 392 392 392 ALA ALA B . n 
B 1 393 GLN 393 393 393 GLN GLN B . n 
B 1 394 ASP 394 394 394 ASP ASP B . n 
B 1 395 ILE 395 395 395 ILE ILE B . n 
B 1 396 LEU 396 396 396 LEU LEU B . n 
B 1 397 ASP 397 397 397 ASP ASP B . n 
B 1 398 THR 398 398 398 THR THR B . n 
B 1 399 LEU 399 399 399 LEU LEU B . n 
B 1 400 GLU 400 400 400 GLU GLU B . n 
B 1 401 ASP 401 401 401 ASP ASP B . n 
B 1 402 ASN 402 402 402 ASN ASN B . n 
B 1 403 ARG 403 403 403 ARG ARG B . n 
B 1 404 GLU 404 404 404 GLU GLU B . n 
B 1 405 TRP 405 405 405 TRP TRP B . n 
B 1 406 TYR 406 406 406 TYR TYR B . n 
B 1 407 GLN 407 407 407 GLN GLN B . n 
B 1 408 SER 408 408 408 SER SER B . n 
B 1 409 THR 409 409 409 THR THR B . n 
B 1 410 ILE 410 410 410 ILE ILE B . n 
B 1 411 PRO 411 411 ?   ?   ?   B . n 
B 1 412 GLN 412 412 ?   ?   ?   B . n 
B 1 413 SER 413 413 ?   ?   ?   B . n 
B 1 414 PRO 414 414 ?   ?   ?   B . n 
B 1 415 SER 415 415 ?   ?   ?   B . n 
B 1 416 PRO 416 416 ?   ?   ?   B . n 
B 1 417 ALA 417 417 ?   ?   ?   B . n 
B 1 418 PRO 418 418 ?   ?   ?   B . n 
B 1 419 ASP 419 419 ?   ?   ?   B . n 
B 1 420 ASP 420 420 ?   ?   ?   B . n 
B 1 421 PRO 421 421 ?   ?   ?   B . n 
B 1 422 GLU 422 422 ?   ?   ?   B . n 
B 1 423 GLU 423 423 ?   ?   ?   B . n 
B 1 424 GLY 424 424 ?   ?   ?   B . n 
B 1 425 ARG 425 425 ?   ?   ?   B . n 
B 1 426 GLN 426 426 ?   ?   ?   B . n 
B 1 427 GLY 427 427 ?   ?   ?   B . n 
B 1 428 GLN 428 428 ?   ?   ?   B . n 
B 1 429 THR 429 429 ?   ?   ?   B . n 
B 1 430 GLU 430 430 ?   ?   ?   B . n 
B 1 431 LYS 431 431 ?   ?   ?   B . n 
B 1 432 PHE 432 432 ?   ?   ?   B . n 
B 1 433 GLN 433 433 ?   ?   ?   B . n 
B 1 434 PHE 434 434 ?   ?   ?   B . n 
B 1 435 GLU 435 435 ?   ?   ?   B . n 
B 1 436 LEU 436 436 ?   ?   ?   B . n 
B 1 437 THR 437 437 ?   ?   ?   B . n 
B 1 438 LEU 438 438 ?   ?   ?   B . n 
B 1 439 GLU 439 439 ?   ?   ?   B . n 
B 1 440 GLU 440 440 ?   ?   ?   B . n 
B 1 441 ASP 441 441 ?   ?   ?   B . n 
B 1 442 GLY 442 442 ?   ?   ?   B . n 
B 1 443 GLU 443 443 ?   ?   ?   B . n 
B 1 444 SER 444 444 ?   ?   ?   B . n 
B 1 445 ASP 445 445 ?   ?   ?   B . n 
B 1 446 THR 446 446 ?   ?   ?   B . n 
B 1 447 GLU 447 447 ?   ?   ?   B . n 
B 1 448 LYS 448 448 ?   ?   ?   B . n 
B 1 449 ASP 449 449 ?   ?   ?   B . n 
B 1 450 SER 450 450 ?   ?   ?   B . n 
B 1 451 GLY 451 451 ?   ?   ?   B . n 
B 1 452 SER 452 452 ?   ?   ?   B . n 
B 1 453 GLN 453 453 ?   ?   ?   B . n 
B 1 454 VAL 454 454 ?   ?   ?   B . n 
B 1 455 GLU 455 455 ?   ?   ?   B . n 
B 1 456 GLU 456 456 ?   ?   ?   B . n 
B 1 457 ASP 457 457 ?   ?   ?   B . n 
B 1 458 THR 458 458 ?   ?   ?   B . n 
B 1 459 SER 459 459 ?   ?   ?   B . n 
B 1 460 CYS 460 460 ?   ?   ?   B . n 
B 1 461 SER 461 461 ?   ?   ?   B . n 
B 1 462 ASP 462 462 ?   ?   ?   B . n 
B 1 463 SER 463 463 ?   ?   ?   B . n 
B 1 464 LYS 464 464 ?   ?   ?   B . n 
B 1 465 THR 465 465 ?   ?   ?   B . n 
B 1 466 LEU 466 466 ?   ?   ?   B . n 
B 1 467 CYS 467 467 ?   ?   ?   B . n 
B 1 468 THR 468 468 ?   ?   ?   B . n 
B 1 469 GLN 469 469 ?   ?   ?   B . n 
B 1 470 ASP 470 470 ?   ?   ?   B . n 
B 1 471 SER 471 471 ?   ?   ?   B . n 
B 1 472 GLU 472 472 ?   ?   ?   B . n 
B 1 473 SER 473 473 ?   ?   ?   B . n 
B 1 474 THR 474 474 ?   ?   ?   B . n 
B 1 475 GLU 475 475 ?   ?   ?   B . n 
B 1 476 ILE 476 476 ?   ?   ?   B . n 
B 1 477 PRO 477 477 ?   ?   ?   B . n 
B 1 478 LEU 478 478 ?   ?   ?   B . n 
B 1 479 ASP 479 479 ?   ?   ?   B . n 
B 1 480 GLU 480 480 ?   ?   ?   B . n 
B 1 481 GLN 481 481 ?   ?   ?   B . n 
B 1 482 VAL 482 482 ?   ?   ?   B . n 
B 1 483 GLU 483 483 ?   ?   ?   B . n 
B 1 484 GLU 484 484 ?   ?   ?   B . n 
B 1 485 GLU 485 485 ?   ?   ?   B . n 
B 1 486 ALA 486 486 ?   ?   ?   B . n 
B 1 487 VAL 487 487 ?   ?   ?   B . n 
B 1 488 GLY 488 488 ?   ?   ?   B . n 
B 1 489 GLU 489 489 ?   ?   ?   B . n 
B 1 490 GLU 490 490 ?   ?   ?   B . n 
B 1 491 GLU 491 491 ?   ?   ?   B . n 
B 1 492 GLU 492 492 ?   ?   ?   B . n 
B 1 493 SER 493 493 ?   ?   ?   B . n 
B 1 494 GLN 494 494 ?   ?   ?   B . n 
B 1 495 PRO 495 495 ?   ?   ?   B . n 
B 1 496 GLU 496 496 ?   ?   ?   B . n 
B 1 497 ALA 497 497 ?   ?   ?   B . n 
B 1 498 CYS 498 498 ?   ?   ?   B . n 
B 1 499 VAL 499 499 ?   ?   ?   B . n 
B 1 500 ILE 500 500 ?   ?   ?   B . n 
B 1 501 ASP 501 501 ?   ?   ?   B . n 
B 1 502 ASP 502 502 ?   ?   ?   B . n 
B 1 503 ARG 503 503 ?   ?   ?   B . n 
B 1 504 SER 504 504 ?   ?   ?   B . n 
B 1 505 PRO 505 505 ?   ?   ?   B . n 
B 1 506 ASP 506 506 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1D8O 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1D8O 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 ZN    1   601 1   ZN    ZN  A . 
D 3 MG    1   602 1   MG    MG  A . 
E 4 A1D8O 1   603 1   A1D8O L27 A . 
F 2 ZN    1   601 2   ZN    ZN  B . 
G 3 MG    1   602 2   MG    MG  B . 
H 4 A1D8O 1   603 2   A1D8O L27 B . 
I 5 HOH   1   701 36  HOH   HOH A . 
I 5 HOH   2   702 126 HOH   HOH A . 
I 5 HOH   3   703 69  HOH   HOH A . 
I 5 HOH   4   704 76  HOH   HOH A . 
I 5 HOH   5   705 190 HOH   HOH A . 
I 5 HOH   6   706 147 HOH   HOH A . 
I 5 HOH   7   707 134 HOH   HOH A . 
I 5 HOH   8   708 158 HOH   HOH A . 
I 5 HOH   9   709 145 HOH   HOH A . 
I 5 HOH   10  710 196 HOH   HOH A . 
I 5 HOH   11  711 75  HOH   HOH A . 
I 5 HOH   12  712 66  HOH   HOH A . 
I 5 HOH   13  713 170 HOH   HOH A . 
I 5 HOH   14  714 108 HOH   HOH A . 
I 5 HOH   15  715 62  HOH   HOH A . 
I 5 HOH   16  716 185 HOH   HOH A . 
I 5 HOH   17  717 135 HOH   HOH A . 
I 5 HOH   18  718 35  HOH   HOH A . 
I 5 HOH   19  719 58  HOH   HOH A . 
I 5 HOH   20  720 202 HOH   HOH A . 
I 5 HOH   21  721 33  HOH   HOH A . 
I 5 HOH   22  722 15  HOH   HOH A . 
I 5 HOH   23  723 111 HOH   HOH A . 
I 5 HOH   24  724 112 HOH   HOH A . 
I 5 HOH   25  725 53  HOH   HOH A . 
I 5 HOH   26  726 193 HOH   HOH A . 
I 5 HOH   27  727 122 HOH   HOH A . 
I 5 HOH   28  728 127 HOH   HOH A . 
I 5 HOH   29  729 169 HOH   HOH A . 
I 5 HOH   30  730 155 HOH   HOH A . 
I 5 HOH   31  731 109 HOH   HOH A . 
I 5 HOH   32  732 168 HOH   HOH A . 
I 5 HOH   33  733 2   HOH   HOH A . 
I 5 HOH   34  734 178 HOH   HOH A . 
I 5 HOH   35  735 101 HOH   HOH A . 
I 5 HOH   36  736 5   HOH   HOH A . 
I 5 HOH   37  737 124 HOH   HOH A . 
I 5 HOH   38  738 117 HOH   HOH A . 
I 5 HOH   39  739 205 HOH   HOH A . 
I 5 HOH   40  740 40  HOH   HOH A . 
I 5 HOH   41  741 130 HOH   HOH A . 
I 5 HOH   42  742 52  HOH   HOH A . 
I 5 HOH   43  743 4   HOH   HOH A . 
I 5 HOH   44  744 115 HOH   HOH A . 
I 5 HOH   45  745 83  HOH   HOH A . 
I 5 HOH   46  746 50  HOH   HOH A . 
I 5 HOH   47  747 128 HOH   HOH A . 
I 5 HOH   48  748 68  HOH   HOH A . 
I 5 HOH   49  749 57  HOH   HOH A . 
I 5 HOH   50  750 138 HOH   HOH A . 
I 5 HOH   51  751 106 HOH   HOH A . 
I 5 HOH   52  752 70  HOH   HOH A . 
I 5 HOH   53  753 14  HOH   HOH A . 
I 5 HOH   54  754 21  HOH   HOH A . 
I 5 HOH   55  755 146 HOH   HOH A . 
I 5 HOH   56  756 179 HOH   HOH A . 
I 5 HOH   57  757 152 HOH   HOH A . 
I 5 HOH   58  758 82  HOH   HOH A . 
I 5 HOH   59  759 54  HOH   HOH A . 
I 5 HOH   60  760 150 HOH   HOH A . 
I 5 HOH   61  761 140 HOH   HOH A . 
I 5 HOH   62  762 29  HOH   HOH A . 
I 5 HOH   63  763 34  HOH   HOH A . 
I 5 HOH   64  764 41  HOH   HOH A . 
I 5 HOH   65  765 132 HOH   HOH A . 
I 5 HOH   66  766 139 HOH   HOH A . 
I 5 HOH   67  767 121 HOH   HOH A . 
I 5 HOH   68  768 86  HOH   HOH A . 
I 5 HOH   69  769 104 HOH   HOH A . 
I 5 HOH   70  770 46  HOH   HOH A . 
I 5 HOH   71  771 195 HOH   HOH A . 
I 5 HOH   72  772 85  HOH   HOH A . 
I 5 HOH   73  773 67  HOH   HOH A . 
I 5 HOH   74  774 153 HOH   HOH A . 
I 5 HOH   75  775 161 HOH   HOH A . 
I 5 HOH   76  776 73  HOH   HOH A . 
I 5 HOH   77  777 201 HOH   HOH A . 
I 5 HOH   78  778 27  HOH   HOH A . 
I 5 HOH   79  779 81  HOH   HOH A . 
I 5 HOH   80  780 30  HOH   HOH A . 
I 5 HOH   81  781 16  HOH   HOH A . 
I 5 HOH   82  782 123 HOH   HOH A . 
I 5 HOH   83  783 1   HOH   HOH A . 
I 5 HOH   84  784 162 HOH   HOH A . 
I 5 HOH   85  785 6   HOH   HOH A . 
I 5 HOH   86  786 197 HOH   HOH A . 
I 5 HOH   87  787 17  HOH   HOH A . 
I 5 HOH   88  788 28  HOH   HOH A . 
I 5 HOH   89  789 47  HOH   HOH A . 
I 5 HOH   90  790 96  HOH   HOH A . 
I 5 HOH   91  791 186 HOH   HOH A . 
I 5 HOH   92  792 72  HOH   HOH A . 
I 5 HOH   93  793 180 HOH   HOH A . 
I 5 HOH   94  794 63  HOH   HOH A . 
I 5 HOH   95  795 95  HOH   HOH A . 
I 5 HOH   96  796 45  HOH   HOH A . 
I 5 HOH   97  797 80  HOH   HOH A . 
I 5 HOH   98  798 149 HOH   HOH A . 
I 5 HOH   99  799 187 HOH   HOH A . 
I 5 HOH   100 800 160 HOH   HOH A . 
I 5 HOH   101 801 129 HOH   HOH A . 
I 5 HOH   102 802 37  HOH   HOH A . 
I 5 HOH   103 803 25  HOH   HOH A . 
I 5 HOH   104 804 90  HOH   HOH A . 
I 5 HOH   105 805 209 HOH   HOH A . 
I 5 HOH   106 806 172 HOH   HOH A . 
I 5 HOH   107 807 71  HOH   HOH A . 
I 5 HOH   108 808 91  HOH   HOH A . 
I 5 HOH   109 809 3   HOH   HOH A . 
I 5 HOH   110 810 142 HOH   HOH A . 
I 5 HOH   111 811 56  HOH   HOH A . 
I 5 HOH   112 812 204 HOH   HOH A . 
I 5 HOH   113 813 141 HOH   HOH A . 
I 5 HOH   114 814 194 HOH   HOH A . 
I 5 HOH   115 815 92  HOH   HOH A . 
I 5 HOH   116 816 116 HOH   HOH A . 
I 5 HOH   117 817 59  HOH   HOH A . 
I 5 HOH   118 818 103 HOH   HOH A . 
I 5 HOH   119 819 39  HOH   HOH A . 
I 5 HOH   120 820 165 HOH   HOH A . 
I 5 HOH   121 821 177 HOH   HOH A . 
I 5 HOH   122 822 184 HOH   HOH A . 
I 5 HOH   123 823 191 HOH   HOH A . 
I 5 HOH   124 824 200 HOH   HOH A . 
I 5 HOH   125 825 18  HOH   HOH A . 
I 5 HOH   126 826 133 HOH   HOH A . 
I 5 HOH   127 827 97  HOH   HOH A . 
J 5 HOH   1   701 208 HOH   HOH B . 
J 5 HOH   2   702 181 HOH   HOH B . 
J 5 HOH   3   703 55  HOH   HOH B . 
J 5 HOH   4   704 175 HOH   HOH B . 
J 5 HOH   5   705 159 HOH   HOH B . 
J 5 HOH   6   706 10  HOH   HOH B . 
J 5 HOH   7   707 88  HOH   HOH B . 
J 5 HOH   8   708 51  HOH   HOH B . 
J 5 HOH   9   709 44  HOH   HOH B . 
J 5 HOH   10  710 144 HOH   HOH B . 
J 5 HOH   11  711 23  HOH   HOH B . 
J 5 HOH   12  712 93  HOH   HOH B . 
J 5 HOH   13  713 78  HOH   HOH B . 
J 5 HOH   14  714 113 HOH   HOH B . 
J 5 HOH   15  715 48  HOH   HOH B . 
J 5 HOH   16  716 137 HOH   HOH B . 
J 5 HOH   17  717 11  HOH   HOH B . 
J 5 HOH   18  718 87  HOH   HOH B . 
J 5 HOH   19  719 107 HOH   HOH B . 
J 5 HOH   20  720 154 HOH   HOH B . 
J 5 HOH   21  721 8   HOH   HOH B . 
J 5 HOH   22  722 148 HOH   HOH B . 
J 5 HOH   23  723 99  HOH   HOH B . 
J 5 HOH   24  724 110 HOH   HOH B . 
J 5 HOH   25  725 60  HOH   HOH B . 
J 5 HOH   26  726 20  HOH   HOH B . 
J 5 HOH   27  727 77  HOH   HOH B . 
J 5 HOH   28  728 143 HOH   HOH B . 
J 5 HOH   29  729 114 HOH   HOH B . 
J 5 HOH   30  730 74  HOH   HOH B . 
J 5 HOH   31  731 22  HOH   HOH B . 
J 5 HOH   32  732 43  HOH   HOH B . 
J 5 HOH   33  733 38  HOH   HOH B . 
J 5 HOH   34  734 19  HOH   HOH B . 
J 5 HOH   35  735 198 HOH   HOH B . 
J 5 HOH   36  736 24  HOH   HOH B . 
J 5 HOH   37  737 174 HOH   HOH B . 
J 5 HOH   38  738 163 HOH   HOH B . 
J 5 HOH   39  739 7   HOH   HOH B . 
J 5 HOH   40  740 12  HOH   HOH B . 
J 5 HOH   41  741 13  HOH   HOH B . 
J 5 HOH   42  742 89  HOH   HOH B . 
J 5 HOH   43  743 183 HOH   HOH B . 
J 5 HOH   44  744 199 HOH   HOH B . 
J 5 HOH   45  745 102 HOH   HOH B . 
J 5 HOH   46  746 42  HOH   HOH B . 
J 5 HOH   47  747 207 HOH   HOH B . 
J 5 HOH   48  748 31  HOH   HOH B . 
J 5 HOH   49  749 188 HOH   HOH B . 
J 5 HOH   50  750 61  HOH   HOH B . 
J 5 HOH   51  751 118 HOH   HOH B . 
J 5 HOH   52  752 166 HOH   HOH B . 
J 5 HOH   53  753 49  HOH   HOH B . 
J 5 HOH   54  754 32  HOH   HOH B . 
J 5 HOH   55  755 151 HOH   HOH B . 
J 5 HOH   56  756 167 HOH   HOH B . 
J 5 HOH   57  757 203 HOH   HOH B . 
J 5 HOH   58  758 189 HOH   HOH B . 
J 5 HOH   59  759 100 HOH   HOH B . 
J 5 HOH   60  760 84  HOH   HOH B . 
J 5 HOH   61  761 192 HOH   HOH B . 
J 5 HOH   62  762 26  HOH   HOH B . 
J 5 HOH   63  763 79  HOH   HOH B . 
J 5 HOH   64  764 131 HOH   HOH B . 
J 5 HOH   65  765 206 HOH   HOH B . 
J 5 HOH   66  766 164 HOH   HOH B . 
J 5 HOH   67  767 94  HOH   HOH B . 
J 5 HOH   68  768 157 HOH   HOH B . 
J 5 HOH   69  769 156 HOH   HOH B . 
J 5 HOH   70  770 105 HOH   HOH B . 
J 5 HOH   71  771 9   HOH   HOH B . 
J 5 HOH   72  772 119 HOH   HOH B . 
J 5 HOH   73  773 98  HOH   HOH B . 
J 5 HOH   74  774 173 HOH   HOH B . 
J 5 HOH   75  775 65  HOH   HOH B . 
J 5 HOH   76  776 182 HOH   HOH B . 
J 5 HOH   77  777 176 HOH   HOH B . 
J 5 HOH   78  778 125 HOH   HOH B . 
J 5 HOH   79  779 171 HOH   HOH B . 
J 5 HOH   80  780 64  HOH   HOH B . 
J 5 HOH   81  781 120 HOH   HOH B . 
J 5 HOH   82  782 136 HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? V8        1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.10_2155 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? 171.39.46 3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZQ2 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     58.188 
_cell.length_a_esd                 ? 
_cell.length_b                     80.167 
_cell.length_b_esd                 ? 
_cell.length_c                     162.820 
_cell.length_c_esd                 ? 
_cell.volume                       759523.863 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZQ2 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZQ2 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.64 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          25.17 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M HEPES (pH 7.4), 0.1M MgCl2, 15% PEG3350, 10% isopropanol, 25% ethylene glycol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU HyPix-3000' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-03-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.5418 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        RIGAKU 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.5418 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          19.012013584 
_reflns.entry_id                                       8ZQ2 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.1 
_reflns.d_resolution_low                               23.67 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     45159 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          14.0 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.067 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.1 
_reflns_shell.d_res_low                                     2.2 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3667 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.3 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.3 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.269 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.1148489754 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZQ2 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.10001445151 
_refine.ls_d_res_low                             23.6696426253 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     45100 
_refine.ls_number_reflns_R_free                  2269 
_refine.ls_number_reflns_R_work                  42831 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.5848789966 
_refine.ls_percent_reflns_R_free                 5.0310421286 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.212068923271 
_refine.ls_R_factor_R_free                       0.250849586213 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.209976908012 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34967131188 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               NONE 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      5WQA 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.9638574336 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.232876351763 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.10001445151 
_refine_hist.d_res_low                        23.6696426253 
_refine_hist.number_atoms_solvent             209 
_refine_hist.number_atoms_total               5507 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        5248 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         50 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0037160822501 ? 5404 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.663623616454  ? 7342 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0382345057893 ? 840  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0042665946166 ? 964  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.2415370041   ? 3276 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.100015 2.1456   . . 138 2629 99.2467718795 . . . . 0.241516061907 . . . . . . . . . . . 0.28444486204  
'X-RAY DIFFRACTION' 2.1456   2.1955   . . 142 2614 99.1723641598 . . . . 0.244312502139 . . . . . . . . . . . 0.297782604857 
'X-RAY DIFFRACTION' 2.1955   2.2504   . . 149 2642 99.1826581379 . . . . 0.235659867653 . . . . . . . . . . . 0.287963794223 
'X-RAY DIFFRACTION' 2.2504   2.3112   . . 119 2631 99.2063492063 . . . . 0.223600129675 . . . . . . . . . . . 0.329983201974 
'X-RAY DIFFRACTION' 2.3112   2.3791   . . 147 2613 99.4236311239 . . . . 0.222024384693 . . . . . . . . . . . 0.267411792194 
'X-RAY DIFFRACTION' 2.3791   2.4558   . . 155 2625 99.5345506624 . . . . 0.220413810275 . . . . . . . . . . . 0.255367089227 
'X-RAY DIFFRACTION' 2.4558   2.5435   . . 143 2688 99.8589065256 . . . . 0.225737007748 . . . . . . . . . . . 0.294021653523 
'X-RAY DIFFRACTION' 2.5435   2.6452   . . 144 2658 100.0         . . . . 0.226036758024 . . . . . . . . . . . 0.294466255829 
'X-RAY DIFFRACTION' 2.6452   2.7655   . . 149 2675 100.0         . . . . 0.225623992296 . . . . . . . . . . . 0.287813396441 
'X-RAY DIFFRACTION' 2.7655   2.911    . . 147 2660 100.0         . . . . 0.224559366699 . . . . . . . . . . . 0.285882501689 
'X-RAY DIFFRACTION' 2.911    3.093    . . 134 2692 100.0         . . . . 0.21948807301  . . . . . . . . . . . 0.248061838892 
'X-RAY DIFFRACTION' 3.093    3.3312   . . 124 2684 99.9288256228 . . . . 0.220069642696 . . . . . . . . . . . 0.265643183931 
'X-RAY DIFFRACTION' 3.3312   3.6654   . . 123 2736 99.8602864129 . . . . 0.209940515229 . . . . . . . . . . . 0.243777319711 
'X-RAY DIFFRACTION' 3.6654   4.1932   . . 148 2707 99.7205728257 . . . . 0.194468434558 . . . . . . . . . . . 0.222733496811 
'X-RAY DIFFRACTION' 4.1932   5.2734   . . 167 2724 99.586634516  . . . . 0.176521771724 . . . . . . . . . . . 0.208426185935 
'X-RAY DIFFRACTION' 5.2734   23.66964 . . 140 2853 98.7137203166 . . . . 0.177044389642 . . . . . . . . . . . 0.18379418665  
# 
_struct.entry_id                     8ZQ2 
_struct.title                        'The crystal structure of PDE4D with isoaurostatin derivatives 2-1' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZQ2 
_struct_keywords.text            'Inhibitor, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 2 ? 
G N N 3 ? 
H N N 4 ? 
I N N 5 ? 
J N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PDE4D_HUMAN 
_struct_ref.pdbx_db_accession          Q08499 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIP
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL
LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLS
NPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE
QVEEEAVGEEEESQPEACVIDDRSPD
;
_struct_ref.pdbx_align_begin           303 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZQ2 A 1 ? 506 ? Q08499 303 ? 808 ? 1 506 
2 1 8ZQ2 B 1 ? 506 ? Q08499 303 ? 808 ? 1 506 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1950  ? 
1 MORE         -102  ? 
1 'SSA (A^2)'  27260 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 87  ? LEU A 96  ? GLU A 87  LEU A 96  1 ? 10 
HELX_P HELX_P2  AA2 GLU A 97  ? VAL A 99  ? GLU A 97  VAL A 99  5 ? 3  
HELX_P HELX_P3  AA3 HIS A 105 ? SER A 113 ? HIS A 105 SER A 113 1 ? 9  
HELX_P HELX_P4  AA4 ARG A 116 ? ARG A 129 ? ARG A 116 ARG A 129 1 ? 14 
HELX_P HELX_P5  AA5 ASP A 130 ? PHE A 135 ? ASP A 130 PHE A 135 1 ? 6  
HELX_P HELX_P6  AA6 PRO A 138 ? HIS A 152 ? PRO A 138 HIS A 152 1 ? 15 
HELX_P HELX_P7  AA7 ASN A 161 ? SER A 177 ? ASN A 161 SER A 177 1 ? 17 
HELX_P HELX_P8  AA8 THR A 178 ? GLU A 182 ? THR A 178 GLU A 182 5 ? 5  
HELX_P HELX_P9  AA9 THR A 186 ? HIS A 200 ? THR A 186 HIS A 200 1 ? 15 
HELX_P HELX_P10 AB1 SER A 208 ? THR A 215 ? SER A 208 THR A 215 1 ? 8  
HELX_P HELX_P11 AB2 SER A 217 ? ASN A 224 ? SER A 217 ASN A 224 1 ? 8  
HELX_P HELX_P12 AB3 SER A 227 ? LEU A 240 ? SER A 227 LEU A 240 1 ? 14 
HELX_P HELX_P13 AB4 LEU A 241 ? GLU A 243 ? LEU A 241 GLU A 243 5 ? 3  
HELX_P HELX_P14 AB5 THR A 253 ? ALA A 270 ? THR A 253 ALA A 270 1 ? 18 
HELX_P HELX_P15 AB6 THR A 271 ? SER A 274 ? THR A 271 SER A 274 5 ? 4  
HELX_P HELX_P16 AB7 LYS A 275 ? THR A 289 ? LYS A 275 THR A 289 1 ? 15 
HELX_P HELX_P17 AB8 ASN A 302 ? LEU A 319 ? ASN A 302 LEU A 319 1 ? 18 
HELX_P HELX_P18 AB9 SER A 320 ? LYS A 324 ? SER A 320 LYS A 324 5 ? 5  
HELX_P HELX_P19 AC1 PRO A 325 ? ARG A 350 ? PRO A 325 ARG A 350 1 ? 26 
HELX_P HELX_P20 AC2 SER A 364 ? ILE A 376 ? SER A 364 ILE A 376 1 ? 13 
HELX_P HELX_P21 AC3 ILE A 376 ? VAL A 388 ? ILE A 376 VAL A 388 1 ? 13 
HELX_P HELX_P22 AC4 ALA A 392 ? THR A 409 ? ALA A 392 THR A 409 1 ? 18 
HELX_P HELX_P23 AC5 GLN B 88  ? LEU B 96  ? GLN B 88  LEU B 96  1 ? 9  
HELX_P HELX_P24 AC6 GLU B 97  ? VAL B 99  ? GLU B 97  VAL B 99  5 ? 3  
HELX_P HELX_P25 AC7 HIS B 105 ? SER B 113 ? HIS B 105 SER B 113 1 ? 9  
HELX_P HELX_P26 AC8 ARG B 116 ? ARG B 129 ? ARG B 116 ARG B 129 1 ? 14 
HELX_P HELX_P27 AC9 ASP B 130 ? PHE B 135 ? ASP B 130 PHE B 135 1 ? 6  
HELX_P HELX_P28 AD1 PRO B 138 ? HIS B 152 ? PRO B 138 HIS B 152 1 ? 15 
HELX_P HELX_P29 AD2 ASN B 161 ? SER B 177 ? ASN B 161 SER B 177 1 ? 17 
HELX_P HELX_P30 AD3 PHE B 185 ? HIS B 200 ? PHE B 185 HIS B 200 1 ? 16 
HELX_P HELX_P31 AD4 SER B 208 ? THR B 215 ? SER B 208 THR B 215 1 ? 8  
HELX_P HELX_P32 AD5 SER B 217 ? ASN B 224 ? SER B 217 ASN B 224 1 ? 8  
HELX_P HELX_P33 AD6 SER B 227 ? LEU B 240 ? SER B 227 LEU B 240 1 ? 14 
HELX_P HELX_P34 AD7 LEU B 241 ? GLU B 243 ? LEU B 241 GLU B 243 5 ? 3  
HELX_P HELX_P35 AD8 THR B 253 ? ALA B 270 ? THR B 253 ALA B 270 1 ? 18 
HELX_P HELX_P36 AD9 THR B 271 ? SER B 274 ? THR B 271 SER B 274 5 ? 4  
HELX_P HELX_P37 AE1 LYS B 275 ? THR B 289 ? LYS B 275 THR B 289 1 ? 15 
HELX_P HELX_P38 AE2 ASN B 302 ? LEU B 319 ? ASN B 302 LEU B 319 1 ? 18 
HELX_P HELX_P39 AE3 SER B 320 ? LYS B 324 ? SER B 320 LYS B 324 5 ? 5  
HELX_P HELX_P40 AE4 PRO B 325 ? ARG B 350 ? PRO B 325 ARG B 350 1 ? 26 
HELX_P HELX_P41 AE5 SER B 364 ? ILE B 376 ? SER B 364 ILE B 376 1 ? 13 
HELX_P HELX_P42 AE6 ILE B 376 ? VAL B 388 ? ILE B 376 VAL B 388 1 ? 13 
HELX_P HELX_P43 AE7 ALA B 392 ? THR B 409 ? ALA B 392 THR B 409 1 ? 18 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 164 NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 164 A ZN  601 1_555 ? ? ? ? ? ? ? 2.136 ? ? 
metalc2  metalc ? ? A HIS 200 NE2 ? ? ? 1_555 C ZN  . ZN ? ? A HIS 200 A ZN  601 1_555 ? ? ? ? ? ? ? 2.223 ? ? 
metalc3  metalc ? ? A ASP 201 OD2 ? ? ? 1_555 C ZN  . ZN ? ? A ASP 201 A ZN  601 1_555 ? ? ? ? ? ? ? 2.070 ? ? 
metalc4  metalc ? ? A ASP 201 OD1 ? ? ? 1_555 D MG  . MG ? ? A ASP 201 A MG  602 1_555 ? ? ? ? ? ? ? 2.109 ? ? 
metalc5  metalc ? ? A ASP 318 OD1 ? ? ? 1_555 C ZN  . ZN ? ? A ASP 318 A ZN  601 1_555 ? ? ? ? ? ? ? 2.177 ? ? 
metalc6  metalc ? ? C ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  601 A HOH 733 1_555 ? ? ? ? ? ? ? 2.061 ? ? 
metalc7  metalc ? ? C ZN  .   ZN  ? ? ? 1_555 I HOH . O  ? ? A ZN  601 A HOH 783 1_555 ? ? ? ? ? ? ? 2.152 ? ? 
metalc8  metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 733 1_555 ? ? ? ? ? ? ? 2.022 ? ? 
metalc9  metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 736 1_555 ? ? ? ? ? ? ? 2.088 ? ? 
metalc10 metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 743 1_555 ? ? ? ? ? ? ? 2.111 ? ? 
metalc11 metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 785 1_555 ? ? ? ? ? ? ? 2.055 ? ? 
metalc12 metalc ? ? D MG  .   MG  ? ? ? 1_555 I HOH . O  ? ? A MG  602 A HOH 809 1_555 ? ? ? ? ? ? ? 2.052 ? ? 
metalc13 metalc ? ? B HIS 164 NE2 ? ? ? 1_555 F ZN  . ZN ? ? B HIS 164 B ZN  601 1_555 ? ? ? ? ? ? ? 2.279 ? ? 
metalc14 metalc ? ? B HIS 200 NE2 ? ? ? 1_555 F ZN  . ZN ? ? B HIS 200 B ZN  601 1_555 ? ? ? ? ? ? ? 2.172 ? ? 
metalc15 metalc ? ? B ASP 201 OD2 ? ? ? 1_555 F ZN  . ZN ? ? B ASP 201 B ZN  601 1_555 ? ? ? ? ? ? ? 2.079 ? ? 
metalc16 metalc ? ? B ASP 201 OD1 ? ? ? 1_555 G MG  . MG ? ? B ASP 201 B MG  602 1_555 ? ? ? ? ? ? ? 2.142 ? ? 
metalc17 metalc ? ? B ASP 318 OD1 ? ? ? 1_555 F ZN  . ZN ? ? B ASP 318 B ZN  601 1_555 ? ? ? ? ? ? ? 2.127 ? ? 
metalc18 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? B ZN  601 B HOH 721 1_555 ? ? ? ? ? ? ? 2.068 ? ? 
metalc19 metalc ? ? F ZN  .   ZN  ? ? ? 1_555 J HOH . O  ? ? B ZN  601 B HOH 739 1_555 ? ? ? ? ? ? ? 2.264 ? ? 
metalc20 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 706 1_555 ? ? ? ? ? ? ? 2.172 ? ? 
metalc21 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 717 1_555 ? ? ? ? ? ? ? 2.055 ? ? 
metalc22 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 721 1_555 ? ? ? ? ? ? ? 2.011 ? ? 
metalc23 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 740 1_555 ? ? ? ? ? ? ? 2.201 ? ? 
metalc24 metalc ? ? G MG  .   MG  ? ? ? 1_555 J HOH . O  ? ? B MG  602 B HOH 771 1_555 ? ? ? ? ? ? ? 2.041 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 NE2 ? A HIS 200 ? A HIS 200 ? 1_555 90.7  ? 
2  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD2 ? A ASP 201 ? A ASP 201 ? 1_555 89.4  ? 
3  NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD2 ? A ASP 201 ? A ASP 201 ? 1_555 82.6  ? 
4  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 88.6  ? 
5  NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 88.0  ? 
6  OD2 ? A ASP 201 ? A ASP 201 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 170.3 ? 
7  NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 733 ? 1_555 174.5 ? 
8  NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 733 ? 1_555 93.5  ? 
9  OD2 ? A ASP 201 ? A ASP 201 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 733 ? 1_555 87.6  ? 
10 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 733 ? 1_555 95.1  ? 
11 NE2 ? A HIS 164 ? A HIS 164 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 783 ? 1_555 89.3  ? 
12 NE2 ? A HIS 200 ? A HIS 200 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 783 ? 1_555 178.4 ? 
13 OD2 ? A ASP 201 ? A ASP 201 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 783 ? 1_555 99.1  ? 
14 OD1 ? A ASP 318 ? A ASP 318 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 783 ? 1_555 90.4  ? 
15 O   ? I HOH .   ? A HOH 733 ? 1_555 ZN ? C ZN . ? A ZN 601 ? 1_555 O   ? I HOH .   ? A HOH 783 ? 1_555 86.6  ? 
16 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 733 ? 1_555 96.9  ? 
17 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 736 ? 1_555 160.7 ? 
18 O   ? I HOH .   ? A HOH 733 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 736 ? 1_555 97.3  ? 
19 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 743 ? 1_555 83.6  ? 
20 O   ? I HOH .   ? A HOH 733 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 743 ? 1_555 99.0  ? 
21 O   ? I HOH .   ? A HOH 736 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 743 ? 1_555 81.2  ? 
22 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 785 ? 1_555 86.0  ? 
23 O   ? I HOH .   ? A HOH 733 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 785 ? 1_555 169.8 ? 
24 O   ? I HOH .   ? A HOH 736 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 785 ? 1_555 82.3  ? 
25 O   ? I HOH .   ? A HOH 743 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 785 ? 1_555 91.0  ? 
26 OD1 ? A ASP 201 ? A ASP 201 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 809 ? 1_555 100.6 ? 
27 O   ? I HOH .   ? A HOH 733 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 809 ? 1_555 84.9  ? 
28 O   ? I HOH .   ? A HOH 736 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 809 ? 1_555 93.7  ? 
29 O   ? I HOH .   ? A HOH 743 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 809 ? 1_555 174.0 ? 
30 O   ? I HOH .   ? A HOH 785 ? 1_555 MG ? D MG . ? A MG 602 ? 1_555 O   ? I HOH .   ? A HOH 809 ? 1_555 85.0  ? 
31 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 90.4  ? 
32 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 88.8  ? 
33 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 82.8  ? 
34 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 82.4  ? 
35 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 88.6  ? 
36 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 167.7 ? 
37 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 721 ? 1_555 174.0 ? 
38 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 721 ? 1_555 95.5  ? 
39 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 721 ? 1_555 93.0  ? 
40 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 721 ? 1_555 96.6  ? 
41 NE2 ? B HIS 164 ? B HIS 164 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 739 ? 1_555 87.7  ? 
42 NE2 ? B HIS 200 ? B HIS 200 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 739 ? 1_555 176.4 ? 
43 OD2 ? B ASP 201 ? B ASP 201 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 739 ? 1_555 100.2 ? 
44 OD1 ? B ASP 318 ? B ASP 318 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 739 ? 1_555 88.1  ? 
45 O   ? J HOH .   ? B HOH 721 ? 1_555 ZN ? F ZN . ? B ZN 601 ? 1_555 O   ? J HOH .   ? B HOH 739 ? 1_555 86.4  ? 
46 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 706 ? 1_555 79.3  ? 
47 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 717 ? 1_555 164.3 ? 
48 O   ? J HOH .   ? B HOH 706 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 717 ? 1_555 87.1  ? 
49 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 721 ? 1_555 94.1  ? 
50 O   ? J HOH .   ? B HOH 706 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 721 ? 1_555 98.0  ? 
51 O   ? J HOH .   ? B HOH 717 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 721 ? 1_555 95.5  ? 
52 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 740 ? 1_555 83.3  ? 
53 O   ? J HOH .   ? B HOH 706 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 740 ? 1_555 88.6  ? 
54 O   ? J HOH .   ? B HOH 717 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 740 ? 1_555 88.6  ? 
55 O   ? J HOH .   ? B HOH 721 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 740 ? 1_555 172.4 ? 
56 OD1 ? B ASP 201 ? B ASP 201 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 771 ? 1_555 98.2  ? 
57 O   ? J HOH .   ? B HOH 706 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 771 ? 1_555 176.1 ? 
58 O   ? J HOH .   ? B HOH 717 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 771 ? 1_555 95.0  ? 
59 O   ? J HOH .   ? B HOH 721 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 771 ? 1_555 85.1  ? 
60 O   ? J HOH .   ? B HOH 740 ? 1_555 MG ? G MG . ? B MG 602 ? 1_555 O   ? J HOH .   ? B HOH 771 ? 1_555 88.2  ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 HIS 389 A . ? HIS 389 A PRO 390 A ? PRO 390 A 1 6.29   
2 GLU 182 B . ? GLU 182 B ALA 183 B ? ALA 183 B 1 -12.12 
3 HIS 389 B . ? HIS 389 B PRO 390 B ? PRO 390 B 1 5.01   
# 
_pdbx_entry_details.entry_id                   8ZQ2 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A HOH 804 ? ? O   A HOH 818 ? ? 2.00 
2 1 O   A LEU 252 ? ? O   A HOH 701 ? ? 2.05 
3 1 OE2 B GLU 338 ? ? NH2 B ARG 342 ? ? 2.13 
4 1 O   A HOH 702 ? ? O   A HOH 821 ? ? 2.15 
5 1 O   A HOH 788 ? ? O   A HOH 822 ? ? 2.16 
6 1 O   A HOH 798 ? ? O   A HOH 823 ? ? 2.19 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             NE 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_1              342 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CZ 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_2              342 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             NH1 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_3              342 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                116.24 
_pdbx_validate_rmsd_angle.angle_target_value         120.30 
_pdbx_validate_rmsd_angle.angle_deviation            -4.06 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.50 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 161 ? ? -124.54 -167.77 
2 1 ASN A 362 ? ? -157.90 74.13   
3 1 ILE A 376 ? ? -128.16 -65.31  
4 1 ASN B 161 ? ? -128.12 -165.47 
5 1 VAL B 184 ? ? -149.30 22.84   
6 1 THR B 186 ? ? 55.40   163.38  
7 1 ASN B 362 ? ? -158.78 50.56   
8 1 HIS B 389 ? ? -39.16  121.87  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A ALA 2   ? A ALA 2   
3   1 Y 1 A SER 3   ? A SER 3   
4   1 Y 1 A ASN 4   ? A ASN 4   
5   1 Y 1 A LYS 5   ? A LYS 5   
6   1 Y 1 A PHE 6   ? A PHE 6   
7   1 Y 1 A LYS 7   ? A LYS 7   
8   1 Y 1 A ARG 8   ? A ARG 8   
9   1 Y 1 A MET 9   ? A MET 9   
10  1 Y 1 A LEU 10  ? A LEU 10  
11  1 Y 1 A ASN 11  ? A ASN 11  
12  1 Y 1 A ARG 12  ? A ARG 12  
13  1 Y 1 A GLU 13  ? A GLU 13  
14  1 Y 1 A LEU 14  ? A LEU 14  
15  1 Y 1 A THR 15  ? A THR 15  
16  1 Y 1 A HIS 16  ? A HIS 16  
17  1 Y 1 A LEU 17  ? A LEU 17  
18  1 Y 1 A SER 18  ? A SER 18  
19  1 Y 1 A GLU 19  ? A GLU 19  
20  1 Y 1 A MET 20  ? A MET 20  
21  1 Y 1 A SER 21  ? A SER 21  
22  1 Y 1 A ARG 22  ? A ARG 22  
23  1 Y 1 A SER 23  ? A SER 23  
24  1 Y 1 A GLY 24  ? A GLY 24  
25  1 Y 1 A ASN 25  ? A ASN 25  
26  1 Y 1 A GLN 26  ? A GLN 26  
27  1 Y 1 A VAL 27  ? A VAL 27  
28  1 Y 1 A SER 28  ? A SER 28  
29  1 Y 1 A GLU 29  ? A GLU 29  
30  1 Y 1 A PHE 30  ? A PHE 30  
31  1 Y 1 A ILE 31  ? A ILE 31  
32  1 Y 1 A SER 32  ? A SER 32  
33  1 Y 1 A ASN 33  ? A ASN 33  
34  1 Y 1 A THR 34  ? A THR 34  
35  1 Y 1 A PHE 35  ? A PHE 35  
36  1 Y 1 A LEU 36  ? A LEU 36  
37  1 Y 1 A ASP 37  ? A ASP 37  
38  1 Y 1 A LYS 38  ? A LYS 38  
39  1 Y 1 A GLN 39  ? A GLN 39  
40  1 Y 1 A HIS 40  ? A HIS 40  
41  1 Y 1 A GLU 41  ? A GLU 41  
42  1 Y 1 A VAL 42  ? A VAL 42  
43  1 Y 1 A GLU 43  ? A GLU 43  
44  1 Y 1 A ILE 44  ? A ILE 44  
45  1 Y 1 A PRO 45  ? A PRO 45  
46  1 Y 1 A SER 46  ? A SER 46  
47  1 Y 1 A PRO 47  ? A PRO 47  
48  1 Y 1 A THR 48  ? A THR 48  
49  1 Y 1 A GLN 49  ? A GLN 49  
50  1 Y 1 A LYS 50  ? A LYS 50  
51  1 Y 1 A GLU 51  ? A GLU 51  
52  1 Y 1 A LYS 52  ? A LYS 52  
53  1 Y 1 A GLU 53  ? A GLU 53  
54  1 Y 1 A LYS 54  ? A LYS 54  
55  1 Y 1 A LYS 55  ? A LYS 55  
56  1 Y 1 A LYS 56  ? A LYS 56  
57  1 Y 1 A ARG 57  ? A ARG 57  
58  1 Y 1 A PRO 58  ? A PRO 58  
59  1 Y 1 A MET 59  ? A MET 59  
60  1 Y 1 A SER 60  ? A SER 60  
61  1 Y 1 A GLN 61  ? A GLN 61  
62  1 Y 1 A ILE 62  ? A ILE 62  
63  1 Y 1 A SER 63  ? A SER 63  
64  1 Y 1 A GLY 64  ? A GLY 64  
65  1 Y 1 A VAL 65  ? A VAL 65  
66  1 Y 1 A LYS 66  ? A LYS 66  
67  1 Y 1 A LYS 67  ? A LYS 67  
68  1 Y 1 A LEU 68  ? A LEU 68  
69  1 Y 1 A MET 69  ? A MET 69  
70  1 Y 1 A HIS 70  ? A HIS 70  
71  1 Y 1 A SER 71  ? A SER 71  
72  1 Y 1 A SER 72  ? A SER 72  
73  1 Y 1 A SER 73  ? A SER 73  
74  1 Y 1 A LEU 74  ? A LEU 74  
75  1 Y 1 A THR 75  ? A THR 75  
76  1 Y 1 A ASN 76  ? A ASN 76  
77  1 Y 1 A SER 77  ? A SER 77  
78  1 Y 1 A SER 78  ? A SER 78  
79  1 Y 1 A ILE 79  ? A ILE 79  
80  1 Y 1 A PRO 80  ? A PRO 80  
81  1 Y 1 A ARG 81  ? A ARG 81  
82  1 Y 1 A PHE 82  ? A PHE 82  
83  1 Y 1 A GLY 83  ? A GLY 83  
84  1 Y 1 A VAL 84  ? A VAL 84  
85  1 Y 1 A LYS 85  ? A LYS 85  
86  1 Y 1 A THR 86  ? A THR 86  
87  1 Y 1 A PRO 411 ? A PRO 411 
88  1 Y 1 A GLN 412 ? A GLN 412 
89  1 Y 1 A SER 413 ? A SER 413 
90  1 Y 1 A PRO 414 ? A PRO 414 
91  1 Y 1 A SER 415 ? A SER 415 
92  1 Y 1 A PRO 416 ? A PRO 416 
93  1 Y 1 A ALA 417 ? A ALA 417 
94  1 Y 1 A PRO 418 ? A PRO 418 
95  1 Y 1 A ASP 419 ? A ASP 419 
96  1 Y 1 A ASP 420 ? A ASP 420 
97  1 Y 1 A PRO 421 ? A PRO 421 
98  1 Y 1 A GLU 422 ? A GLU 422 
99  1 Y 1 A GLU 423 ? A GLU 423 
100 1 Y 1 A GLY 424 ? A GLY 424 
101 1 Y 1 A ARG 425 ? A ARG 425 
102 1 Y 1 A GLN 426 ? A GLN 426 
103 1 Y 1 A GLY 427 ? A GLY 427 
104 1 Y 1 A GLN 428 ? A GLN 428 
105 1 Y 1 A THR 429 ? A THR 429 
106 1 Y 1 A GLU 430 ? A GLU 430 
107 1 Y 1 A LYS 431 ? A LYS 431 
108 1 Y 1 A PHE 432 ? A PHE 432 
109 1 Y 1 A GLN 433 ? A GLN 433 
110 1 Y 1 A PHE 434 ? A PHE 434 
111 1 Y 1 A GLU 435 ? A GLU 435 
112 1 Y 1 A LEU 436 ? A LEU 436 
113 1 Y 1 A THR 437 ? A THR 437 
114 1 Y 1 A LEU 438 ? A LEU 438 
115 1 Y 1 A GLU 439 ? A GLU 439 
116 1 Y 1 A GLU 440 ? A GLU 440 
117 1 Y 1 A ASP 441 ? A ASP 441 
118 1 Y 1 A GLY 442 ? A GLY 442 
119 1 Y 1 A GLU 443 ? A GLU 443 
120 1 Y 1 A SER 444 ? A SER 444 
121 1 Y 1 A ASP 445 ? A ASP 445 
122 1 Y 1 A THR 446 ? A THR 446 
123 1 Y 1 A GLU 447 ? A GLU 447 
124 1 Y 1 A LYS 448 ? A LYS 448 
125 1 Y 1 A ASP 449 ? A ASP 449 
126 1 Y 1 A SER 450 ? A SER 450 
127 1 Y 1 A GLY 451 ? A GLY 451 
128 1 Y 1 A SER 452 ? A SER 452 
129 1 Y 1 A GLN 453 ? A GLN 453 
130 1 Y 1 A VAL 454 ? A VAL 454 
131 1 Y 1 A GLU 455 ? A GLU 455 
132 1 Y 1 A GLU 456 ? A GLU 456 
133 1 Y 1 A ASP 457 ? A ASP 457 
134 1 Y 1 A THR 458 ? A THR 458 
135 1 Y 1 A SER 459 ? A SER 459 
136 1 Y 1 A CYS 460 ? A CYS 460 
137 1 Y 1 A SER 461 ? A SER 461 
138 1 Y 1 A ASP 462 ? A ASP 462 
139 1 Y 1 A SER 463 ? A SER 463 
140 1 Y 1 A LYS 464 ? A LYS 464 
141 1 Y 1 A THR 465 ? A THR 465 
142 1 Y 1 A LEU 466 ? A LEU 466 
143 1 Y 1 A CYS 467 ? A CYS 467 
144 1 Y 1 A THR 468 ? A THR 468 
145 1 Y 1 A GLN 469 ? A GLN 469 
146 1 Y 1 A ASP 470 ? A ASP 470 
147 1 Y 1 A SER 471 ? A SER 471 
148 1 Y 1 A GLU 472 ? A GLU 472 
149 1 Y 1 A SER 473 ? A SER 473 
150 1 Y 1 A THR 474 ? A THR 474 
151 1 Y 1 A GLU 475 ? A GLU 475 
152 1 Y 1 A ILE 476 ? A ILE 476 
153 1 Y 1 A PRO 477 ? A PRO 477 
154 1 Y 1 A LEU 478 ? A LEU 478 
155 1 Y 1 A ASP 479 ? A ASP 479 
156 1 Y 1 A GLU 480 ? A GLU 480 
157 1 Y 1 A GLN 481 ? A GLN 481 
158 1 Y 1 A VAL 482 ? A VAL 482 
159 1 Y 1 A GLU 483 ? A GLU 483 
160 1 Y 1 A GLU 484 ? A GLU 484 
161 1 Y 1 A GLU 485 ? A GLU 485 
162 1 Y 1 A ALA 486 ? A ALA 486 
163 1 Y 1 A VAL 487 ? A VAL 487 
164 1 Y 1 A GLY 488 ? A GLY 488 
165 1 Y 1 A GLU 489 ? A GLU 489 
166 1 Y 1 A GLU 490 ? A GLU 490 
167 1 Y 1 A GLU 491 ? A GLU 491 
168 1 Y 1 A GLU 492 ? A GLU 492 
169 1 Y 1 A SER 493 ? A SER 493 
170 1 Y 1 A GLN 494 ? A GLN 494 
171 1 Y 1 A PRO 495 ? A PRO 495 
172 1 Y 1 A GLU 496 ? A GLU 496 
173 1 Y 1 A ALA 497 ? A ALA 497 
174 1 Y 1 A CYS 498 ? A CYS 498 
175 1 Y 1 A VAL 499 ? A VAL 499 
176 1 Y 1 A ILE 500 ? A ILE 500 
177 1 Y 1 A ASP 501 ? A ASP 501 
178 1 Y 1 A ASP 502 ? A ASP 502 
179 1 Y 1 A ARG 503 ? A ARG 503 
180 1 Y 1 A SER 504 ? A SER 504 
181 1 Y 1 A PRO 505 ? A PRO 505 
182 1 Y 1 A ASP 506 ? A ASP 506 
183 1 Y 1 B MET 1   ? B MET 1   
184 1 Y 1 B ALA 2   ? B ALA 2   
185 1 Y 1 B SER 3   ? B SER 3   
186 1 Y 1 B ASN 4   ? B ASN 4   
187 1 Y 1 B LYS 5   ? B LYS 5   
188 1 Y 1 B PHE 6   ? B PHE 6   
189 1 Y 1 B LYS 7   ? B LYS 7   
190 1 Y 1 B ARG 8   ? B ARG 8   
191 1 Y 1 B MET 9   ? B MET 9   
192 1 Y 1 B LEU 10  ? B LEU 10  
193 1 Y 1 B ASN 11  ? B ASN 11  
194 1 Y 1 B ARG 12  ? B ARG 12  
195 1 Y 1 B GLU 13  ? B GLU 13  
196 1 Y 1 B LEU 14  ? B LEU 14  
197 1 Y 1 B THR 15  ? B THR 15  
198 1 Y 1 B HIS 16  ? B HIS 16  
199 1 Y 1 B LEU 17  ? B LEU 17  
200 1 Y 1 B SER 18  ? B SER 18  
201 1 Y 1 B GLU 19  ? B GLU 19  
202 1 Y 1 B MET 20  ? B MET 20  
203 1 Y 1 B SER 21  ? B SER 21  
204 1 Y 1 B ARG 22  ? B ARG 22  
205 1 Y 1 B SER 23  ? B SER 23  
206 1 Y 1 B GLY 24  ? B GLY 24  
207 1 Y 1 B ASN 25  ? B ASN 25  
208 1 Y 1 B GLN 26  ? B GLN 26  
209 1 Y 1 B VAL 27  ? B VAL 27  
210 1 Y 1 B SER 28  ? B SER 28  
211 1 Y 1 B GLU 29  ? B GLU 29  
212 1 Y 1 B PHE 30  ? B PHE 30  
213 1 Y 1 B ILE 31  ? B ILE 31  
214 1 Y 1 B SER 32  ? B SER 32  
215 1 Y 1 B ASN 33  ? B ASN 33  
216 1 Y 1 B THR 34  ? B THR 34  
217 1 Y 1 B PHE 35  ? B PHE 35  
218 1 Y 1 B LEU 36  ? B LEU 36  
219 1 Y 1 B ASP 37  ? B ASP 37  
220 1 Y 1 B LYS 38  ? B LYS 38  
221 1 Y 1 B GLN 39  ? B GLN 39  
222 1 Y 1 B HIS 40  ? B HIS 40  
223 1 Y 1 B GLU 41  ? B GLU 41  
224 1 Y 1 B VAL 42  ? B VAL 42  
225 1 Y 1 B GLU 43  ? B GLU 43  
226 1 Y 1 B ILE 44  ? B ILE 44  
227 1 Y 1 B PRO 45  ? B PRO 45  
228 1 Y 1 B SER 46  ? B SER 46  
229 1 Y 1 B PRO 47  ? B PRO 47  
230 1 Y 1 B THR 48  ? B THR 48  
231 1 Y 1 B GLN 49  ? B GLN 49  
232 1 Y 1 B LYS 50  ? B LYS 50  
233 1 Y 1 B GLU 51  ? B GLU 51  
234 1 Y 1 B LYS 52  ? B LYS 52  
235 1 Y 1 B GLU 53  ? B GLU 53  
236 1 Y 1 B LYS 54  ? B LYS 54  
237 1 Y 1 B LYS 55  ? B LYS 55  
238 1 Y 1 B LYS 56  ? B LYS 56  
239 1 Y 1 B ARG 57  ? B ARG 57  
240 1 Y 1 B PRO 58  ? B PRO 58  
241 1 Y 1 B MET 59  ? B MET 59  
242 1 Y 1 B SER 60  ? B SER 60  
243 1 Y 1 B GLN 61  ? B GLN 61  
244 1 Y 1 B ILE 62  ? B ILE 62  
245 1 Y 1 B SER 63  ? B SER 63  
246 1 Y 1 B GLY 64  ? B GLY 64  
247 1 Y 1 B VAL 65  ? B VAL 65  
248 1 Y 1 B LYS 66  ? B LYS 66  
249 1 Y 1 B LYS 67  ? B LYS 67  
250 1 Y 1 B LEU 68  ? B LEU 68  
251 1 Y 1 B MET 69  ? B MET 69  
252 1 Y 1 B HIS 70  ? B HIS 70  
253 1 Y 1 B SER 71  ? B SER 71  
254 1 Y 1 B SER 72  ? B SER 72  
255 1 Y 1 B SER 73  ? B SER 73  
256 1 Y 1 B LEU 74  ? B LEU 74  
257 1 Y 1 B THR 75  ? B THR 75  
258 1 Y 1 B ASN 76  ? B ASN 76  
259 1 Y 1 B SER 77  ? B SER 77  
260 1 Y 1 B SER 78  ? B SER 78  
261 1 Y 1 B ILE 79  ? B ILE 79  
262 1 Y 1 B PRO 80  ? B PRO 80  
263 1 Y 1 B ARG 81  ? B ARG 81  
264 1 Y 1 B PHE 82  ? B PHE 82  
265 1 Y 1 B GLY 83  ? B GLY 83  
266 1 Y 1 B VAL 84  ? B VAL 84  
267 1 Y 1 B LYS 85  ? B LYS 85  
268 1 Y 1 B THR 86  ? B THR 86  
269 1 Y 1 B PRO 411 ? B PRO 411 
270 1 Y 1 B GLN 412 ? B GLN 412 
271 1 Y 1 B SER 413 ? B SER 413 
272 1 Y 1 B PRO 414 ? B PRO 414 
273 1 Y 1 B SER 415 ? B SER 415 
274 1 Y 1 B PRO 416 ? B PRO 416 
275 1 Y 1 B ALA 417 ? B ALA 417 
276 1 Y 1 B PRO 418 ? B PRO 418 
277 1 Y 1 B ASP 419 ? B ASP 419 
278 1 Y 1 B ASP 420 ? B ASP 420 
279 1 Y 1 B PRO 421 ? B PRO 421 
280 1 Y 1 B GLU 422 ? B GLU 422 
281 1 Y 1 B GLU 423 ? B GLU 423 
282 1 Y 1 B GLY 424 ? B GLY 424 
283 1 Y 1 B ARG 425 ? B ARG 425 
284 1 Y 1 B GLN 426 ? B GLN 426 
285 1 Y 1 B GLY 427 ? B GLY 427 
286 1 Y 1 B GLN 428 ? B GLN 428 
287 1 Y 1 B THR 429 ? B THR 429 
288 1 Y 1 B GLU 430 ? B GLU 430 
289 1 Y 1 B LYS 431 ? B LYS 431 
290 1 Y 1 B PHE 432 ? B PHE 432 
291 1 Y 1 B GLN 433 ? B GLN 433 
292 1 Y 1 B PHE 434 ? B PHE 434 
293 1 Y 1 B GLU 435 ? B GLU 435 
294 1 Y 1 B LEU 436 ? B LEU 436 
295 1 Y 1 B THR 437 ? B THR 437 
296 1 Y 1 B LEU 438 ? B LEU 438 
297 1 Y 1 B GLU 439 ? B GLU 439 
298 1 Y 1 B GLU 440 ? B GLU 440 
299 1 Y 1 B ASP 441 ? B ASP 441 
300 1 Y 1 B GLY 442 ? B GLY 442 
301 1 Y 1 B GLU 443 ? B GLU 443 
302 1 Y 1 B SER 444 ? B SER 444 
303 1 Y 1 B ASP 445 ? B ASP 445 
304 1 Y 1 B THR 446 ? B THR 446 
305 1 Y 1 B GLU 447 ? B GLU 447 
306 1 Y 1 B LYS 448 ? B LYS 448 
307 1 Y 1 B ASP 449 ? B ASP 449 
308 1 Y 1 B SER 450 ? B SER 450 
309 1 Y 1 B GLY 451 ? B GLY 451 
310 1 Y 1 B SER 452 ? B SER 452 
311 1 Y 1 B GLN 453 ? B GLN 453 
312 1 Y 1 B VAL 454 ? B VAL 454 
313 1 Y 1 B GLU 455 ? B GLU 455 
314 1 Y 1 B GLU 456 ? B GLU 456 
315 1 Y 1 B ASP 457 ? B ASP 457 
316 1 Y 1 B THR 458 ? B THR 458 
317 1 Y 1 B SER 459 ? B SER 459 
318 1 Y 1 B CYS 460 ? B CYS 460 
319 1 Y 1 B SER 461 ? B SER 461 
320 1 Y 1 B ASP 462 ? B ASP 462 
321 1 Y 1 B SER 463 ? B SER 463 
322 1 Y 1 B LYS 464 ? B LYS 464 
323 1 Y 1 B THR 465 ? B THR 465 
324 1 Y 1 B LEU 466 ? B LEU 466 
325 1 Y 1 B CYS 467 ? B CYS 467 
326 1 Y 1 B THR 468 ? B THR 468 
327 1 Y 1 B GLN 469 ? B GLN 469 
328 1 Y 1 B ASP 470 ? B ASP 470 
329 1 Y 1 B SER 471 ? B SER 471 
330 1 Y 1 B GLU 472 ? B GLU 472 
331 1 Y 1 B SER 473 ? B SER 473 
332 1 Y 1 B THR 474 ? B THR 474 
333 1 Y 1 B GLU 475 ? B GLU 475 
334 1 Y 1 B ILE 476 ? B ILE 476 
335 1 Y 1 B PRO 477 ? B PRO 477 
336 1 Y 1 B LEU 478 ? B LEU 478 
337 1 Y 1 B ASP 479 ? B ASP 479 
338 1 Y 1 B GLU 480 ? B GLU 480 
339 1 Y 1 B GLN 481 ? B GLN 481 
340 1 Y 1 B VAL 482 ? B VAL 482 
341 1 Y 1 B GLU 483 ? B GLU 483 
342 1 Y 1 B GLU 484 ? B GLU 484 
343 1 Y 1 B GLU 485 ? B GLU 485 
344 1 Y 1 B ALA 486 ? B ALA 486 
345 1 Y 1 B VAL 487 ? B VAL 487 
346 1 Y 1 B GLY 488 ? B GLY 488 
347 1 Y 1 B GLU 489 ? B GLU 489 
348 1 Y 1 B GLU 490 ? B GLU 490 
349 1 Y 1 B GLU 491 ? B GLU 491 
350 1 Y 1 B GLU 492 ? B GLU 492 
351 1 Y 1 B SER 493 ? B SER 493 
352 1 Y 1 B GLN 494 ? B GLN 494 
353 1 Y 1 B PRO 495 ? B PRO 495 
354 1 Y 1 B GLU 496 ? B GLU 496 
355 1 Y 1 B ALA 497 ? B ALA 497 
356 1 Y 1 B CYS 498 ? B CYS 498 
357 1 Y 1 B VAL 499 ? B VAL 499 
358 1 Y 1 B ILE 500 ? B ILE 500 
359 1 Y 1 B ASP 501 ? B ASP 501 
360 1 Y 1 B ASP 502 ? B ASP 502 
361 1 Y 1 B ARG 503 ? B ARG 503 
362 1 Y 1 B SER 504 ? B SER 504 
363 1 Y 1 B PRO 505 ? B PRO 505 
364 1 Y 1 B ASP 506 ? B ASP 506 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1D8O C10  C  Y N 1   
A1D8O C12  C  N N 2   
A1D8O C13  C  Y N 3   
A1D8O C14  C  Y N 4   
A1D8O C15  C  Y N 5   
A1D8O C16  C  Y N 6   
A1D8O O1   O  N N 7   
A1D8O C2   C  N N 8   
A1D8O C3   C  N N 9   
A1D8O C4   C  Y N 10  
A1D8O C5   C  Y N 11  
A1D8O C6   C  Y N 12  
A1D8O C7   C  Y N 13  
A1D8O O8   O  N N 14  
A1D8O C9   C  Y N 15  
A1D8O O11  O  N N 16  
A1D8O O17  O  N N 17  
A1D8O C18  C  N N 18  
A1D8O C19  C  Y N 19  
A1D8O O20  O  N N 20  
A1D8O C21  C  N N 21  
A1D8O C22  C  N N 22  
A1D8O C23  C  Y N 23  
A1D8O H1   H  N N 24  
A1D8O H2   H  N N 25  
A1D8O H3   H  N N 26  
A1D8O H4   H  N N 27  
A1D8O H5   H  N N 28  
A1D8O H6   H  N N 29  
A1D8O H7   H  N N 30  
A1D8O H8   H  N N 31  
A1D8O H9   H  N N 32  
A1D8O H10  H  N N 33  
A1D8O H11  H  N N 34  
A1D8O H12  H  N N 35  
A1D8O H13  H  N N 36  
A1D8O H14  H  N N 37  
A1D8O H15  H  N N 38  
A1D8O H16  H  N N 39  
ALA   N    N  N N 40  
ALA   CA   C  N S 41  
ALA   C    C  N N 42  
ALA   O    O  N N 43  
ALA   CB   C  N N 44  
ALA   OXT  O  N N 45  
ALA   H    H  N N 46  
ALA   H2   H  N N 47  
ALA   HA   H  N N 48  
ALA   HB1  H  N N 49  
ALA   HB2  H  N N 50  
ALA   HB3  H  N N 51  
ALA   HXT  H  N N 52  
ARG   N    N  N N 53  
ARG   CA   C  N S 54  
ARG   C    C  N N 55  
ARG   O    O  N N 56  
ARG   CB   C  N N 57  
ARG   CG   C  N N 58  
ARG   CD   C  N N 59  
ARG   NE   N  N N 60  
ARG   CZ   C  N N 61  
ARG   NH1  N  N N 62  
ARG   NH2  N  N N 63  
ARG   OXT  O  N N 64  
ARG   H    H  N N 65  
ARG   H2   H  N N 66  
ARG   HA   H  N N 67  
ARG   HB2  H  N N 68  
ARG   HB3  H  N N 69  
ARG   HG2  H  N N 70  
ARG   HG3  H  N N 71  
ARG   HD2  H  N N 72  
ARG   HD3  H  N N 73  
ARG   HE   H  N N 74  
ARG   HH11 H  N N 75  
ARG   HH12 H  N N 76  
ARG   HH21 H  N N 77  
ARG   HH22 H  N N 78  
ARG   HXT  H  N N 79  
ASN   N    N  N N 80  
ASN   CA   C  N S 81  
ASN   C    C  N N 82  
ASN   O    O  N N 83  
ASN   CB   C  N N 84  
ASN   CG   C  N N 85  
ASN   OD1  O  N N 86  
ASN   ND2  N  N N 87  
ASN   OXT  O  N N 88  
ASN   H    H  N N 89  
ASN   H2   H  N N 90  
ASN   HA   H  N N 91  
ASN   HB2  H  N N 92  
ASN   HB3  H  N N 93  
ASN   HD21 H  N N 94  
ASN   HD22 H  N N 95  
ASN   HXT  H  N N 96  
ASP   N    N  N N 97  
ASP   CA   C  N S 98  
ASP   C    C  N N 99  
ASP   O    O  N N 100 
ASP   CB   C  N N 101 
ASP   CG   C  N N 102 
ASP   OD1  O  N N 103 
ASP   OD2  O  N N 104 
ASP   OXT  O  N N 105 
ASP   H    H  N N 106 
ASP   H2   H  N N 107 
ASP   HA   H  N N 108 
ASP   HB2  H  N N 109 
ASP   HB3  H  N N 110 
ASP   HD2  H  N N 111 
ASP   HXT  H  N N 112 
CYS   N    N  N N 113 
CYS   CA   C  N R 114 
CYS   C    C  N N 115 
CYS   O    O  N N 116 
CYS   CB   C  N N 117 
CYS   SG   S  N N 118 
CYS   OXT  O  N N 119 
CYS   H    H  N N 120 
CYS   H2   H  N N 121 
CYS   HA   H  N N 122 
CYS   HB2  H  N N 123 
CYS   HB3  H  N N 124 
CYS   HG   H  N N 125 
CYS   HXT  H  N N 126 
GLN   N    N  N N 127 
GLN   CA   C  N S 128 
GLN   C    C  N N 129 
GLN   O    O  N N 130 
GLN   CB   C  N N 131 
GLN   CG   C  N N 132 
GLN   CD   C  N N 133 
GLN   OE1  O  N N 134 
GLN   NE2  N  N N 135 
GLN   OXT  O  N N 136 
GLN   H    H  N N 137 
GLN   H2   H  N N 138 
GLN   HA   H  N N 139 
GLN   HB2  H  N N 140 
GLN   HB3  H  N N 141 
GLN   HG2  H  N N 142 
GLN   HG3  H  N N 143 
GLN   HE21 H  N N 144 
GLN   HE22 H  N N 145 
GLN   HXT  H  N N 146 
GLU   N    N  N N 147 
GLU   CA   C  N S 148 
GLU   C    C  N N 149 
GLU   O    O  N N 150 
GLU   CB   C  N N 151 
GLU   CG   C  N N 152 
GLU   CD   C  N N 153 
GLU   OE1  O  N N 154 
GLU   OE2  O  N N 155 
GLU   OXT  O  N N 156 
GLU   H    H  N N 157 
GLU   H2   H  N N 158 
GLU   HA   H  N N 159 
GLU   HB2  H  N N 160 
GLU   HB3  H  N N 161 
GLU   HG2  H  N N 162 
GLU   HG3  H  N N 163 
GLU   HE2  H  N N 164 
GLU   HXT  H  N N 165 
GLY   N    N  N N 166 
GLY   CA   C  N N 167 
GLY   C    C  N N 168 
GLY   O    O  N N 169 
GLY   OXT  O  N N 170 
GLY   H    H  N N 171 
GLY   H2   H  N N 172 
GLY   HA2  H  N N 173 
GLY   HA3  H  N N 174 
GLY   HXT  H  N N 175 
HIS   N    N  N N 176 
HIS   CA   C  N S 177 
HIS   C    C  N N 178 
HIS   O    O  N N 179 
HIS   CB   C  N N 180 
HIS   CG   C  Y N 181 
HIS   ND1  N  Y N 182 
HIS   CD2  C  Y N 183 
HIS   CE1  C  Y N 184 
HIS   NE2  N  Y N 185 
HIS   OXT  O  N N 186 
HIS   H    H  N N 187 
HIS   H2   H  N N 188 
HIS   HA   H  N N 189 
HIS   HB2  H  N N 190 
HIS   HB3  H  N N 191 
HIS   HD1  H  N N 192 
HIS   HD2  H  N N 193 
HIS   HE1  H  N N 194 
HIS   HE2  H  N N 195 
HIS   HXT  H  N N 196 
HOH   O    O  N N 197 
HOH   H1   H  N N 198 
HOH   H2   H  N N 199 
ILE   N    N  N N 200 
ILE   CA   C  N S 201 
ILE   C    C  N N 202 
ILE   O    O  N N 203 
ILE   CB   C  N S 204 
ILE   CG1  C  N N 205 
ILE   CG2  C  N N 206 
ILE   CD1  C  N N 207 
ILE   OXT  O  N N 208 
ILE   H    H  N N 209 
ILE   H2   H  N N 210 
ILE   HA   H  N N 211 
ILE   HB   H  N N 212 
ILE   HG12 H  N N 213 
ILE   HG13 H  N N 214 
ILE   HG21 H  N N 215 
ILE   HG22 H  N N 216 
ILE   HG23 H  N N 217 
ILE   HD11 H  N N 218 
ILE   HD12 H  N N 219 
ILE   HD13 H  N N 220 
ILE   HXT  H  N N 221 
LEU   N    N  N N 222 
LEU   CA   C  N S 223 
LEU   C    C  N N 224 
LEU   O    O  N N 225 
LEU   CB   C  N N 226 
LEU   CG   C  N N 227 
LEU   CD1  C  N N 228 
LEU   CD2  C  N N 229 
LEU   OXT  O  N N 230 
LEU   H    H  N N 231 
LEU   H2   H  N N 232 
LEU   HA   H  N N 233 
LEU   HB2  H  N N 234 
LEU   HB3  H  N N 235 
LEU   HG   H  N N 236 
LEU   HD11 H  N N 237 
LEU   HD12 H  N N 238 
LEU   HD13 H  N N 239 
LEU   HD21 H  N N 240 
LEU   HD22 H  N N 241 
LEU   HD23 H  N N 242 
LEU   HXT  H  N N 243 
LYS   N    N  N N 244 
LYS   CA   C  N S 245 
LYS   C    C  N N 246 
LYS   O    O  N N 247 
LYS   CB   C  N N 248 
LYS   CG   C  N N 249 
LYS   CD   C  N N 250 
LYS   CE   C  N N 251 
LYS   NZ   N  N N 252 
LYS   OXT  O  N N 253 
LYS   H    H  N N 254 
LYS   H2   H  N N 255 
LYS   HA   H  N N 256 
LYS   HB2  H  N N 257 
LYS   HB3  H  N N 258 
LYS   HG2  H  N N 259 
LYS   HG3  H  N N 260 
LYS   HD2  H  N N 261 
LYS   HD3  H  N N 262 
LYS   HE2  H  N N 263 
LYS   HE3  H  N N 264 
LYS   HZ1  H  N N 265 
LYS   HZ2  H  N N 266 
LYS   HZ3  H  N N 267 
LYS   HXT  H  N N 268 
MET   N    N  N N 269 
MET   CA   C  N S 270 
MET   C    C  N N 271 
MET   O    O  N N 272 
MET   CB   C  N N 273 
MET   CG   C  N N 274 
MET   SD   S  N N 275 
MET   CE   C  N N 276 
MET   OXT  O  N N 277 
MET   H    H  N N 278 
MET   H2   H  N N 279 
MET   HA   H  N N 280 
MET   HB2  H  N N 281 
MET   HB3  H  N N 282 
MET   HG2  H  N N 283 
MET   HG3  H  N N 284 
MET   HE1  H  N N 285 
MET   HE2  H  N N 286 
MET   HE3  H  N N 287 
MET   HXT  H  N N 288 
MG    MG   MG N N 289 
PHE   N    N  N N 290 
PHE   CA   C  N S 291 
PHE   C    C  N N 292 
PHE   O    O  N N 293 
PHE   CB   C  N N 294 
PHE   CG   C  Y N 295 
PHE   CD1  C  Y N 296 
PHE   CD2  C  Y N 297 
PHE   CE1  C  Y N 298 
PHE   CE2  C  Y N 299 
PHE   CZ   C  Y N 300 
PHE   OXT  O  N N 301 
PHE   H    H  N N 302 
PHE   H2   H  N N 303 
PHE   HA   H  N N 304 
PHE   HB2  H  N N 305 
PHE   HB3  H  N N 306 
PHE   HD1  H  N N 307 
PHE   HD2  H  N N 308 
PHE   HE1  H  N N 309 
PHE   HE2  H  N N 310 
PHE   HZ   H  N N 311 
PHE   HXT  H  N N 312 
PRO   N    N  N N 313 
PRO   CA   C  N S 314 
PRO   C    C  N N 315 
PRO   O    O  N N 316 
PRO   CB   C  N N 317 
PRO   CG   C  N N 318 
PRO   CD   C  N N 319 
PRO   OXT  O  N N 320 
PRO   H    H  N N 321 
PRO   HA   H  N N 322 
PRO   HB2  H  N N 323 
PRO   HB3  H  N N 324 
PRO   HG2  H  N N 325 
PRO   HG3  H  N N 326 
PRO   HD2  H  N N 327 
PRO   HD3  H  N N 328 
PRO   HXT  H  N N 329 
SER   N    N  N N 330 
SER   CA   C  N S 331 
SER   C    C  N N 332 
SER   O    O  N N 333 
SER   CB   C  N N 334 
SER   OG   O  N N 335 
SER   OXT  O  N N 336 
SER   H    H  N N 337 
SER   H2   H  N N 338 
SER   HA   H  N N 339 
SER   HB2  H  N N 340 
SER   HB3  H  N N 341 
SER   HG   H  N N 342 
SER   HXT  H  N N 343 
THR   N    N  N N 344 
THR   CA   C  N S 345 
THR   C    C  N N 346 
THR   O    O  N N 347 
THR   CB   C  N R 348 
THR   OG1  O  N N 349 
THR   CG2  C  N N 350 
THR   OXT  O  N N 351 
THR   H    H  N N 352 
THR   H2   H  N N 353 
THR   HA   H  N N 354 
THR   HB   H  N N 355 
THR   HG1  H  N N 356 
THR   HG21 H  N N 357 
THR   HG22 H  N N 358 
THR   HG23 H  N N 359 
THR   HXT  H  N N 360 
TRP   N    N  N N 361 
TRP   CA   C  N S 362 
TRP   C    C  N N 363 
TRP   O    O  N N 364 
TRP   CB   C  N N 365 
TRP   CG   C  Y N 366 
TRP   CD1  C  Y N 367 
TRP   CD2  C  Y N 368 
TRP   NE1  N  Y N 369 
TRP   CE2  C  Y N 370 
TRP   CE3  C  Y N 371 
TRP   CZ2  C  Y N 372 
TRP   CZ3  C  Y N 373 
TRP   CH2  C  Y N 374 
TRP   OXT  O  N N 375 
TRP   H    H  N N 376 
TRP   H2   H  N N 377 
TRP   HA   H  N N 378 
TRP   HB2  H  N N 379 
TRP   HB3  H  N N 380 
TRP   HD1  H  N N 381 
TRP   HE1  H  N N 382 
TRP   HE3  H  N N 383 
TRP   HZ2  H  N N 384 
TRP   HZ3  H  N N 385 
TRP   HH2  H  N N 386 
TRP   HXT  H  N N 387 
TYR   N    N  N N 388 
TYR   CA   C  N S 389 
TYR   C    C  N N 390 
TYR   O    O  N N 391 
TYR   CB   C  N N 392 
TYR   CG   C  Y N 393 
TYR   CD1  C  Y N 394 
TYR   CD2  C  Y N 395 
TYR   CE1  C  Y N 396 
TYR   CE2  C  Y N 397 
TYR   CZ   C  Y N 398 
TYR   OH   O  N N 399 
TYR   OXT  O  N N 400 
TYR   H    H  N N 401 
TYR   H2   H  N N 402 
TYR   HA   H  N N 403 
TYR   HB2  H  N N 404 
TYR   HB3  H  N N 405 
TYR   HD1  H  N N 406 
TYR   HD2  H  N N 407 
TYR   HE1  H  N N 408 
TYR   HE2  H  N N 409 
TYR   HH   H  N N 410 
TYR   HXT  H  N N 411 
VAL   N    N  N N 412 
VAL   CA   C  N S 413 
VAL   C    C  N N 414 
VAL   O    O  N N 415 
VAL   CB   C  N N 416 
VAL   CG1  C  N N 417 
VAL   CG2  C  N N 418 
VAL   OXT  O  N N 419 
VAL   H    H  N N 420 
VAL   H2   H  N N 421 
VAL   HA   H  N N 422 
VAL   HB   H  N N 423 
VAL   HG11 H  N N 424 
VAL   HG12 H  N N 425 
VAL   HG13 H  N N 426 
VAL   HG21 H  N N 427 
VAL   HG22 H  N N 428 
VAL   HG23 H  N N 429 
VAL   HXT  H  N N 430 
ZN    ZN   ZN N N 431 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1D8O O8  C7   sing N N 1   
A1D8O C7  C9   doub Y N 2   
A1D8O C7  C6   sing Y N 3   
A1D8O C9  C10  sing Y N 4   
A1D8O C6  C5   doub Y N 5   
A1D8O C10 O11  sing N N 6   
A1D8O C10 C4   doub Y N 7   
A1D8O C5  C4   sing Y N 8   
A1D8O O11 C2   sing N N 9   
A1D8O C4  C3   sing N N 10  
A1D8O C2  C3   sing N N 11  
A1D8O C2  O1   doub N N 12  
A1D8O C3  C12  doub N Z 13  
A1D8O C12 C13  sing N N 14  
A1D8O C13 C23  doub Y N 15  
A1D8O C13 C14  sing Y N 16  
A1D8O C23 C19  sing Y N 17  
A1D8O C14 C15  doub Y N 18  
A1D8O C21 C22  sing N N 19  
A1D8O C21 O20  sing N N 20  
A1D8O C19 O20  sing N N 21  
A1D8O C19 C16  doub Y N 22  
A1D8O C15 C16  sing Y N 23  
A1D8O C16 O17  sing N N 24  
A1D8O O17 C18  sing N N 25  
A1D8O C12 H1   sing N N 26  
A1D8O C14 H2   sing N N 27  
A1D8O C15 H3   sing N N 28  
A1D8O C5  H4   sing N N 29  
A1D8O C6  H5   sing N N 30  
A1D8O O8  H6   sing N N 31  
A1D8O C9  H7   sing N N 32  
A1D8O C18 H8   sing N N 33  
A1D8O C18 H9   sing N N 34  
A1D8O C18 H10  sing N N 35  
A1D8O C21 H11  sing N N 36  
A1D8O C21 H12  sing N N 37  
A1D8O C22 H13  sing N N 38  
A1D8O C22 H14  sing N N 39  
A1D8O C22 H15  sing N N 40  
A1D8O C23 H16  sing N N 41  
ALA   N   CA   sing N N 42  
ALA   N   H    sing N N 43  
ALA   N   H2   sing N N 44  
ALA   CA  C    sing N N 45  
ALA   CA  CB   sing N N 46  
ALA   CA  HA   sing N N 47  
ALA   C   O    doub N N 48  
ALA   C   OXT  sing N N 49  
ALA   CB  HB1  sing N N 50  
ALA   CB  HB2  sing N N 51  
ALA   CB  HB3  sing N N 52  
ALA   OXT HXT  sing N N 53  
ARG   N   CA   sing N N 54  
ARG   N   H    sing N N 55  
ARG   N   H2   sing N N 56  
ARG   CA  C    sing N N 57  
ARG   CA  CB   sing N N 58  
ARG   CA  HA   sing N N 59  
ARG   C   O    doub N N 60  
ARG   C   OXT  sing N N 61  
ARG   CB  CG   sing N N 62  
ARG   CB  HB2  sing N N 63  
ARG   CB  HB3  sing N N 64  
ARG   CG  CD   sing N N 65  
ARG   CG  HG2  sing N N 66  
ARG   CG  HG3  sing N N 67  
ARG   CD  NE   sing N N 68  
ARG   CD  HD2  sing N N 69  
ARG   CD  HD3  sing N N 70  
ARG   NE  CZ   sing N N 71  
ARG   NE  HE   sing N N 72  
ARG   CZ  NH1  sing N N 73  
ARG   CZ  NH2  doub N N 74  
ARG   NH1 HH11 sing N N 75  
ARG   NH1 HH12 sing N N 76  
ARG   NH2 HH21 sing N N 77  
ARG   NH2 HH22 sing N N 78  
ARG   OXT HXT  sing N N 79  
ASN   N   CA   sing N N 80  
ASN   N   H    sing N N 81  
ASN   N   H2   sing N N 82  
ASN   CA  C    sing N N 83  
ASN   CA  CB   sing N N 84  
ASN   CA  HA   sing N N 85  
ASN   C   O    doub N N 86  
ASN   C   OXT  sing N N 87  
ASN   CB  CG   sing N N 88  
ASN   CB  HB2  sing N N 89  
ASN   CB  HB3  sing N N 90  
ASN   CG  OD1  doub N N 91  
ASN   CG  ND2  sing N N 92  
ASN   ND2 HD21 sing N N 93  
ASN   ND2 HD22 sing N N 94  
ASN   OXT HXT  sing N N 95  
ASP   N   CA   sing N N 96  
ASP   N   H    sing N N 97  
ASP   N   H2   sing N N 98  
ASP   CA  C    sing N N 99  
ASP   CA  CB   sing N N 100 
ASP   CA  HA   sing N N 101 
ASP   C   O    doub N N 102 
ASP   C   OXT  sing N N 103 
ASP   CB  CG   sing N N 104 
ASP   CB  HB2  sing N N 105 
ASP   CB  HB3  sing N N 106 
ASP   CG  OD1  doub N N 107 
ASP   CG  OD2  sing N N 108 
ASP   OD2 HD2  sing N N 109 
ASP   OXT HXT  sing N N 110 
CYS   N   CA   sing N N 111 
CYS   N   H    sing N N 112 
CYS   N   H2   sing N N 113 
CYS   CA  C    sing N N 114 
CYS   CA  CB   sing N N 115 
CYS   CA  HA   sing N N 116 
CYS   C   O    doub N N 117 
CYS   C   OXT  sing N N 118 
CYS   CB  SG   sing N N 119 
CYS   CB  HB2  sing N N 120 
CYS   CB  HB3  sing N N 121 
CYS   SG  HG   sing N N 122 
CYS   OXT HXT  sing N N 123 
GLN   N   CA   sing N N 124 
GLN   N   H    sing N N 125 
GLN   N   H2   sing N N 126 
GLN   CA  C    sing N N 127 
GLN   CA  CB   sing N N 128 
GLN   CA  HA   sing N N 129 
GLN   C   O    doub N N 130 
GLN   C   OXT  sing N N 131 
GLN   CB  CG   sing N N 132 
GLN   CB  HB2  sing N N 133 
GLN   CB  HB3  sing N N 134 
GLN   CG  CD   sing N N 135 
GLN   CG  HG2  sing N N 136 
GLN   CG  HG3  sing N N 137 
GLN   CD  OE1  doub N N 138 
GLN   CD  NE2  sing N N 139 
GLN   NE2 HE21 sing N N 140 
GLN   NE2 HE22 sing N N 141 
GLN   OXT HXT  sing N N 142 
GLU   N   CA   sing N N 143 
GLU   N   H    sing N N 144 
GLU   N   H2   sing N N 145 
GLU   CA  C    sing N N 146 
GLU   CA  CB   sing N N 147 
GLU   CA  HA   sing N N 148 
GLU   C   O    doub N N 149 
GLU   C   OXT  sing N N 150 
GLU   CB  CG   sing N N 151 
GLU   CB  HB2  sing N N 152 
GLU   CB  HB3  sing N N 153 
GLU   CG  CD   sing N N 154 
GLU   CG  HG2  sing N N 155 
GLU   CG  HG3  sing N N 156 
GLU   CD  OE1  doub N N 157 
GLU   CD  OE2  sing N N 158 
GLU   OE2 HE2  sing N N 159 
GLU   OXT HXT  sing N N 160 
GLY   N   CA   sing N N 161 
GLY   N   H    sing N N 162 
GLY   N   H2   sing N N 163 
GLY   CA  C    sing N N 164 
GLY   CA  HA2  sing N N 165 
GLY   CA  HA3  sing N N 166 
GLY   C   O    doub N N 167 
GLY   C   OXT  sing N N 168 
GLY   OXT HXT  sing N N 169 
HIS   N   CA   sing N N 170 
HIS   N   H    sing N N 171 
HIS   N   H2   sing N N 172 
HIS   CA  C    sing N N 173 
HIS   CA  CB   sing N N 174 
HIS   CA  HA   sing N N 175 
HIS   C   O    doub N N 176 
HIS   C   OXT  sing N N 177 
HIS   CB  CG   sing N N 178 
HIS   CB  HB2  sing N N 179 
HIS   CB  HB3  sing N N 180 
HIS   CG  ND1  sing Y N 181 
HIS   CG  CD2  doub Y N 182 
HIS   ND1 CE1  doub Y N 183 
HIS   ND1 HD1  sing N N 184 
HIS   CD2 NE2  sing Y N 185 
HIS   CD2 HD2  sing N N 186 
HIS   CE1 NE2  sing Y N 187 
HIS   CE1 HE1  sing N N 188 
HIS   NE2 HE2  sing N N 189 
HIS   OXT HXT  sing N N 190 
HOH   O   H1   sing N N 191 
HOH   O   H2   sing N N 192 
ILE   N   CA   sing N N 193 
ILE   N   H    sing N N 194 
ILE   N   H2   sing N N 195 
ILE   CA  C    sing N N 196 
ILE   CA  CB   sing N N 197 
ILE   CA  HA   sing N N 198 
ILE   C   O    doub N N 199 
ILE   C   OXT  sing N N 200 
ILE   CB  CG1  sing N N 201 
ILE   CB  CG2  sing N N 202 
ILE   CB  HB   sing N N 203 
ILE   CG1 CD1  sing N N 204 
ILE   CG1 HG12 sing N N 205 
ILE   CG1 HG13 sing N N 206 
ILE   CG2 HG21 sing N N 207 
ILE   CG2 HG22 sing N N 208 
ILE   CG2 HG23 sing N N 209 
ILE   CD1 HD11 sing N N 210 
ILE   CD1 HD12 sing N N 211 
ILE   CD1 HD13 sing N N 212 
ILE   OXT HXT  sing N N 213 
LEU   N   CA   sing N N 214 
LEU   N   H    sing N N 215 
LEU   N   H2   sing N N 216 
LEU   CA  C    sing N N 217 
LEU   CA  CB   sing N N 218 
LEU   CA  HA   sing N N 219 
LEU   C   O    doub N N 220 
LEU   C   OXT  sing N N 221 
LEU   CB  CG   sing N N 222 
LEU   CB  HB2  sing N N 223 
LEU   CB  HB3  sing N N 224 
LEU   CG  CD1  sing N N 225 
LEU   CG  CD2  sing N N 226 
LEU   CG  HG   sing N N 227 
LEU   CD1 HD11 sing N N 228 
LEU   CD1 HD12 sing N N 229 
LEU   CD1 HD13 sing N N 230 
LEU   CD2 HD21 sing N N 231 
LEU   CD2 HD22 sing N N 232 
LEU   CD2 HD23 sing N N 233 
LEU   OXT HXT  sing N N 234 
LYS   N   CA   sing N N 235 
LYS   N   H    sing N N 236 
LYS   N   H2   sing N N 237 
LYS   CA  C    sing N N 238 
LYS   CA  CB   sing N N 239 
LYS   CA  HA   sing N N 240 
LYS   C   O    doub N N 241 
LYS   C   OXT  sing N N 242 
LYS   CB  CG   sing N N 243 
LYS   CB  HB2  sing N N 244 
LYS   CB  HB3  sing N N 245 
LYS   CG  CD   sing N N 246 
LYS   CG  HG2  sing N N 247 
LYS   CG  HG3  sing N N 248 
LYS   CD  CE   sing N N 249 
LYS   CD  HD2  sing N N 250 
LYS   CD  HD3  sing N N 251 
LYS   CE  NZ   sing N N 252 
LYS   CE  HE2  sing N N 253 
LYS   CE  HE3  sing N N 254 
LYS   NZ  HZ1  sing N N 255 
LYS   NZ  HZ2  sing N N 256 
LYS   NZ  HZ3  sing N N 257 
LYS   OXT HXT  sing N N 258 
MET   N   CA   sing N N 259 
MET   N   H    sing N N 260 
MET   N   H2   sing N N 261 
MET   CA  C    sing N N 262 
MET   CA  CB   sing N N 263 
MET   CA  HA   sing N N 264 
MET   C   O    doub N N 265 
MET   C   OXT  sing N N 266 
MET   CB  CG   sing N N 267 
MET   CB  HB2  sing N N 268 
MET   CB  HB3  sing N N 269 
MET   CG  SD   sing N N 270 
MET   CG  HG2  sing N N 271 
MET   CG  HG3  sing N N 272 
MET   SD  CE   sing N N 273 
MET   CE  HE1  sing N N 274 
MET   CE  HE2  sing N N 275 
MET   CE  HE3  sing N N 276 
MET   OXT HXT  sing N N 277 
PHE   N   CA   sing N N 278 
PHE   N   H    sing N N 279 
PHE   N   H2   sing N N 280 
PHE   CA  C    sing N N 281 
PHE   CA  CB   sing N N 282 
PHE   CA  HA   sing N N 283 
PHE   C   O    doub N N 284 
PHE   C   OXT  sing N N 285 
PHE   CB  CG   sing N N 286 
PHE   CB  HB2  sing N N 287 
PHE   CB  HB3  sing N N 288 
PHE   CG  CD1  doub Y N 289 
PHE   CG  CD2  sing Y N 290 
PHE   CD1 CE1  sing Y N 291 
PHE   CD1 HD1  sing N N 292 
PHE   CD2 CE2  doub Y N 293 
PHE   CD2 HD2  sing N N 294 
PHE   CE1 CZ   doub Y N 295 
PHE   CE1 HE1  sing N N 296 
PHE   CE2 CZ   sing Y N 297 
PHE   CE2 HE2  sing N N 298 
PHE   CZ  HZ   sing N N 299 
PHE   OXT HXT  sing N N 300 
PRO   N   CA   sing N N 301 
PRO   N   CD   sing N N 302 
PRO   N   H    sing N N 303 
PRO   CA  C    sing N N 304 
PRO   CA  CB   sing N N 305 
PRO   CA  HA   sing N N 306 
PRO   C   O    doub N N 307 
PRO   C   OXT  sing N N 308 
PRO   CB  CG   sing N N 309 
PRO   CB  HB2  sing N N 310 
PRO   CB  HB3  sing N N 311 
PRO   CG  CD   sing N N 312 
PRO   CG  HG2  sing N N 313 
PRO   CG  HG3  sing N N 314 
PRO   CD  HD2  sing N N 315 
PRO   CD  HD3  sing N N 316 
PRO   OXT HXT  sing N N 317 
SER   N   CA   sing N N 318 
SER   N   H    sing N N 319 
SER   N   H2   sing N N 320 
SER   CA  C    sing N N 321 
SER   CA  CB   sing N N 322 
SER   CA  HA   sing N N 323 
SER   C   O    doub N N 324 
SER   C   OXT  sing N N 325 
SER   CB  OG   sing N N 326 
SER   CB  HB2  sing N N 327 
SER   CB  HB3  sing N N 328 
SER   OG  HG   sing N N 329 
SER   OXT HXT  sing N N 330 
THR   N   CA   sing N N 331 
THR   N   H    sing N N 332 
THR   N   H2   sing N N 333 
THR   CA  C    sing N N 334 
THR   CA  CB   sing N N 335 
THR   CA  HA   sing N N 336 
THR   C   O    doub N N 337 
THR   C   OXT  sing N N 338 
THR   CB  OG1  sing N N 339 
THR   CB  CG2  sing N N 340 
THR   CB  HB   sing N N 341 
THR   OG1 HG1  sing N N 342 
THR   CG2 HG21 sing N N 343 
THR   CG2 HG22 sing N N 344 
THR   CG2 HG23 sing N N 345 
THR   OXT HXT  sing N N 346 
TRP   N   CA   sing N N 347 
TRP   N   H    sing N N 348 
TRP   N   H2   sing N N 349 
TRP   CA  C    sing N N 350 
TRP   CA  CB   sing N N 351 
TRP   CA  HA   sing N N 352 
TRP   C   O    doub N N 353 
TRP   C   OXT  sing N N 354 
TRP   CB  CG   sing N N 355 
TRP   CB  HB2  sing N N 356 
TRP   CB  HB3  sing N N 357 
TRP   CG  CD1  doub Y N 358 
TRP   CG  CD2  sing Y N 359 
TRP   CD1 NE1  sing Y N 360 
TRP   CD1 HD1  sing N N 361 
TRP   CD2 CE2  doub Y N 362 
TRP   CD2 CE3  sing Y N 363 
TRP   NE1 CE2  sing Y N 364 
TRP   NE1 HE1  sing N N 365 
TRP   CE2 CZ2  sing Y N 366 
TRP   CE3 CZ3  doub Y N 367 
TRP   CE3 HE3  sing N N 368 
TRP   CZ2 CH2  doub Y N 369 
TRP   CZ2 HZ2  sing N N 370 
TRP   CZ3 CH2  sing Y N 371 
TRP   CZ3 HZ3  sing N N 372 
TRP   CH2 HH2  sing N N 373 
TRP   OXT HXT  sing N N 374 
TYR   N   CA   sing N N 375 
TYR   N   H    sing N N 376 
TYR   N   H2   sing N N 377 
TYR   CA  C    sing N N 378 
TYR   CA  CB   sing N N 379 
TYR   CA  HA   sing N N 380 
TYR   C   O    doub N N 381 
TYR   C   OXT  sing N N 382 
TYR   CB  CG   sing N N 383 
TYR   CB  HB2  sing N N 384 
TYR   CB  HB3  sing N N 385 
TYR   CG  CD1  doub Y N 386 
TYR   CG  CD2  sing Y N 387 
TYR   CD1 CE1  sing Y N 388 
TYR   CD1 HD1  sing N N 389 
TYR   CD2 CE2  doub Y N 390 
TYR   CD2 HD2  sing N N 391 
TYR   CE1 CZ   doub Y N 392 
TYR   CE1 HE1  sing N N 393 
TYR   CE2 CZ   sing Y N 394 
TYR   CE2 HE2  sing N N 395 
TYR   CZ  OH   sing N N 396 
TYR   OH  HH   sing N N 397 
TYR   OXT HXT  sing N N 398 
VAL   N   CA   sing N N 399 
VAL   N   H    sing N N 400 
VAL   N   H2   sing N N 401 
VAL   CA  C    sing N N 402 
VAL   CA  CB   sing N N 403 
VAL   CA  HA   sing N N 404 
VAL   C   O    doub N N 405 
VAL   C   OXT  sing N N 406 
VAL   CB  CG1  sing N N 407 
VAL   CB  CG2  sing N N 408 
VAL   CB  HB   sing N N 409 
VAL   CG1 HG11 sing N N 410 
VAL   CG1 HG12 sing N N 411 
VAL   CG1 HG13 sing N N 412 
VAL   CG2 HG21 sing N N 413 
VAL   CG2 HG22 sing N N 414 
VAL   CG2 HG23 sing N N 415 
VAL   OXT HXT  sing N N 416 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           22277019 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5WQA 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8ZQ2 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017186 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012474 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006142 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
MG ? ? 9.41153  2.53737 2.59044  63.03566 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 2.14387  29.76375 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLU   A 1 87  ? -8.72663  22.81255  -3.74869  1.000 50.12056 ? 87  GLU   A N   1 
ATOM   2    C  CA  . GLU   A 1 87  ? -9.64668  23.30457  -4.76546  1.000 47.60765 ? 87  GLU   A CA  1 
ATOM   3    C  C   . GLU   A 1 87  ? -10.20625 22.12708  -5.56050  1.000 52.52969 ? 87  GLU   A C   1 
ATOM   4    O  O   . GLU   A 1 87  ? -9.61579  21.04545  -5.57631  1.000 46.02230 ? 87  GLU   A O   1 
ATOM   5    C  CB  . GLU   A 1 87  ? -8.93975  24.30403  -5.68696  1.000 45.56238 ? 87  GLU   A CB  1 
ATOM   6    C  CG  . GLU   A 1 87  ? -9.85515  25.32904  -6.33965  1.000 48.30300 ? 87  GLU   A CG  1 
ATOM   7    C  CD  . GLU   A 1 87  ? -9.09026  26.34128  -7.17671  1.000 57.19552 ? 87  GLU   A CD  1 
ATOM   8    O  OE1 . GLU   A 1 87  ? -7.84531  26.25330  -7.22666  1.000 53.86061 ? 87  GLU   A OE1 1 
ATOM   9    O  OE2 . GLU   A 1 87  ? -9.73041  27.22888  -7.78000  1.000 60.46293 ? 87  GLU   A OE2 1 
ATOM   10   N  N   . GLN   A 1 88  ? -11.35542 22.34110  -6.20797  1.000 46.86358 ? 88  GLN   A N   1 
ATOM   11   C  CA  . GLN   A 1 88  ? -11.96361 21.28191  -7.00887  1.000 45.72353 ? 88  GLN   A CA  1 
ATOM   12   C  C   . GLN   A 1 88  ? -11.02274 20.80717  -8.10970  1.000 43.44341 ? 88  GLN   A C   1 
ATOM   13   O  O   . GLN   A 1 88  ? -11.10584 19.65474  -8.54621  1.000 34.83778 ? 88  GLN   A O   1 
ATOM   14   C  CB  . GLN   A 1 88  ? -13.28557 21.77410  -7.60225  1.000 46.79381 ? 88  GLN   A CB  1 
ATOM   15   C  CG  . GLN   A 1 88  ? -14.15664 20.68572  -8.21528  1.000 45.50847 ? 88  GLN   A CG  1 
ATOM   16   C  CD  . GLN   A 1 88  ? -15.34695 21.24970  -8.97174  1.000 48.08014 ? 88  GLN   A CD  1 
ATOM   17   O  OE1 . GLN   A 1 88  ? -15.62613 20.84777  -10.10178 1.000 43.07859 ? 88  GLN   A OE1 1 
ATOM   18   N  NE2 . GLN   A 1 88  ? -16.05168 22.19005  -8.35192  1.000 51.15959 ? 88  GLN   A NE2 1 
ATOM   19   N  N   . GLU   A 1 89  ? -10.11553 21.67512  -8.55631  1.000 42.84920 ? 89  GLU   A N   1 
ATOM   20   C  CA  . GLU   A 1 89  ? -9.10839  21.32384  -9.54623  1.000 36.73363 ? 89  GLU   A CA  1 
ATOM   21   C  C   . GLU   A 1 89  ? -7.95639  20.50899  -8.96821  1.000 34.76320 ? 89  GLU   A C   1 
ATOM   22   O  O   . GLU   A 1 89  ? -7.32693  19.74171  -9.70840  1.000 31.34368 ? 89  GLU   A O   1 
ATOM   23   C  CB  . GLU   A 1 89  ? -8.55272  22.58766  -10.19237 1.000 42.81948 ? 89  GLU   A CB  1 
ATOM   24   C  CG  . GLU   A 1 89  ? -9.59405  23.49085  -10.83518 1.000 47.88240 ? 89  GLU   A CG  1 
ATOM   25   C  CD  . GLU   A 1 89  ? -9.00168  24.83078  -11.20890 1.000 59.68425 ? 89  GLU   A CD  1 
ATOM   26   O  OE1 . GLU   A 1 89  ? -7.84053  24.84727  -11.66291 1.000 59.76171 ? 89  GLU   A OE1 1 
ATOM   27   O  OE2 . GLU   A 1 89  ? -9.67381  25.86481  -11.03020 1.000 66.93252 ? 89  GLU   A OE2 1 
ATOM   28   N  N   . ASP   A 1 90  ? -7.65160  20.66771  -7.67592  1.000 41.72395 ? 90  ASP   A N   1 
ATOM   29   C  CA  . ASP   A 1 90  ? -6.66213  19.79831  -7.04594  1.000 34.22550 ? 90  ASP   A CA  1 
ATOM   30   C  C   . ASP   A 1 90  ? -7.12590  18.34997  -7.07022  1.000 23.90972 ? 90  ASP   A C   1 
ATOM   31   O  O   . ASP   A 1 90  ? -6.33889  17.44013  -7.35597  1.000 23.39084 ? 90  ASP   A O   1 
ATOM   32   C  CB  . ASP   A 1 90  ? -6.39478  20.24565  -5.60831  1.000 38.13804 ? 90  ASP   A CB  1 
ATOM   33   C  CG  . ASP   A 1 90  ? -5.63889  21.55473  -5.53702  1.000 50.90129 ? 90  ASP   A CG  1 
ATOM   34   O  OD1 . ASP   A 1 90  ? -4.41272  21.54550  -5.77197  1.000 50.46648 ? 90  ASP   A OD1 1 
ATOM   35   O  OD2 . ASP   A 1 90  ? -6.27043  22.59446  -5.25234  1.000 51.28028 ? 90  ASP   A OD2 1 
ATOM   36   N  N   . VAL   A 1 91  ? -8.40849  18.12155  -6.78265  1.000 30.01517 ? 91  VAL   A N   1 
ATOM   37   C  CA  . VAL   A 1 91  ? -8.95292  16.76906  -6.79623  1.000 24.61324 ? 91  VAL   A CA  1 
ATOM   38   C  C   . VAL   A 1 91  ? -8.97809  16.21561  -8.21597  1.000 24.03475 ? 91  VAL   A C   1 
ATOM   39   O  O   . VAL   A 1 91  ? -8.66536  15.04041  -8.44312  1.000 22.66053 ? 91  VAL   A O   1 
ATOM   40   C  CB  . VAL   A 1 91  ? -10.35159 16.76234  -6.15364  1.000 26.62850 ? 91  VAL   A CB  1 
ATOM   41   C  CG1 . VAL   A 1 91  ? -10.95901 15.37573  -6.21735  1.000 27.59188 ? 91  VAL   A CG1 1 
ATOM   42   C  CG2 . VAL   A 1 91  ? -10.27337 17.24873  -4.71329  1.000 32.23679 ? 91  VAL   A CG2 1 
ATOM   43   N  N   . LEU   A 1 92  ? -9.34795  17.04999  -9.19194  1.000 25.38589 ? 92  LEU   A N   1 
ATOM   44   C  CA  . LEU   A 1 92  ? -9.35088  16.61388  -10.58542 1.000 20.71040 ? 92  LEU   A CA  1 
ATOM   45   C  C   . LEU   A 1 92  ? -7.95539  16.19462  -11.02976 1.000 23.24098 ? 92  LEU   A C   1 
ATOM   46   O  O   . LEU   A 1 92  ? -7.77523  15.12359  -11.62102 1.000 19.97973 ? 92  LEU   A O   1 
ATOM   47   C  CB  . LEU   A 1 92  ? -9.89016  17.72835  -11.48327 1.000 19.55272 ? 92  LEU   A CB  1 
ATOM   48   C  CG  . LEU   A 1 92  ? -9.81513  17.47854  -12.99204 1.000 20.12370 ? 92  LEU   A CG  1 
ATOM   49   C  CD1 . LEU   A 1 92  ? -10.59590 16.23136  -13.37652 1.000 10.45238 ? 92  LEU   A CD1 1 
ATOM   50   C  CD2 . LEU   A 1 92  ? -10.31922 18.68896  -13.76133 1.000 19.29761 ? 92  LEU   A CD2 1 
ATOM   51   N  N   . ALA   A 1 93  ? -6.95133  17.02926  -10.74450 1.000 18.71628 ? 93  ALA   A N   1 
ATOM   52   C  CA  . ALA   A 1 93  ? -5.57916  16.69878  -11.11771 1.000 21.78284 ? 93  ALA   A CA  1 
ATOM   53   C  C   . ALA   A 1 93  ? -5.11976  15.40835  -10.45216 1.000 21.16660 ? 93  ALA   A C   1 
ATOM   54   O  O   . ALA   A 1 93  ? -4.40126  14.60798  -11.06250 1.000 25.56874 ? 93  ALA   A O   1 
ATOM   55   C  CB  . ALA   A 1 93  ? -4.64326  17.85082  -10.75267 1.000 19.92626 ? 93  ALA   A CB  1 
ATOM   56   N  N   . LYS   A 1 94  ? -5.52176  15.19086  -9.19819  1.000 20.16949 ? 94  LYS   A N   1 
ATOM   57   C  CA  . LYS   A 1 94  ? -5.17807  13.94949  -8.51239  1.000 25.01734 ? 94  LYS   A CA  1 
ATOM   58   C  C   . LYS   A 1 94  ? -5.80598  12.74979  -9.21038  1.000 25.15589 ? 94  LYS   A C   1 
ATOM   59   O  O   . LYS   A 1 94  ? -5.14849  11.72453  -9.42393  1.000 20.88477 ? 94  LYS   A O   1 
ATOM   60   C  CB  . LYS   A 1 94  ? -5.62684  14.01835  -7.05282  1.000 25.45182 ? 94  LYS   A CB  1 
ATOM   61   C  CG  . LYS   A 1 94  ? -5.10792  12.88479  -6.18438  1.000 26.48678 ? 94  LYS   A CG  1 
ATOM   62   C  CD  . LYS   A 1 94  ? -5.76740  12.90733  -4.81723  1.000 30.67890 ? 94  LYS   A CD  1 
ATOM   63   C  CE  . LYS   A 1 94  ? -7.27491  12.76081  -4.94452  1.000 28.30242 ? 94  LYS   A CE  1 
ATOM   64   N  NZ  . LYS   A 1 94  ? -7.96663  12.93800  -3.63905  1.000 31.49151 ? 94  LYS   A NZ  1 
ATOM   65   N  N   . GLU   A 1 95  ? -7.08604  12.86276  -9.57468  1.000 20.09716 ? 95  GLU   A N   1 
ATOM   66   C  CA  . GLU   A 1 95  ? -7.75767  11.77157  -10.27229 1.000 22.75610 ? 95  GLU   A CA  1 
ATOM   67   C  C   . GLU   A 1 95  ? -7.14213  11.51482  -11.64055 1.000 18.30061 ? 95  GLU   A C   1 
ATOM   68   O  O   . GLU   A 1 95  ? -7.11329  10.36860  -12.10234 1.000 20.17823 ? 95  GLU   A O   1 
ATOM   69   C  CB  . GLU   A 1 95  ? -9.24949  12.07668  -10.41151 1.000 18.79404 ? 95  GLU   A CB  1 
ATOM   70   C  CG  . GLU   A 1 95  ? -10.01090 12.03659  -9.09934  1.000 20.66195 ? 95  GLU   A CG  1 
ATOM   71   C  CD  . GLU   A 1 95  ? -10.11683 10.63413  -8.53194  1.000 23.02756 ? 95  GLU   A CD  1 
ATOM   72   O  OE1 . GLU   A 1 95  ? -10.03751 9.66392   -9.31506  1.000 22.78406 ? 95  GLU   A OE1 1 
ATOM   73   O  OE2 . GLU   A 1 95  ? -10.27158 10.50182  -7.30030  1.000 27.88280 ? 95  GLU   A OE2 1 
ATOM   74   N  N   . LEU   A 1 96  ? -6.64260  12.56071  -12.30064 1.000 18.57024 ? 96  LEU   A N   1 
ATOM   75   C  CA  . LEU   A 1 96  ? -6.03038  12.40074  -13.61312 1.000 22.85345 ? 96  LEU   A CA  1 
ATOM   76   C  C   . LEU   A 1 96  ? -4.65854  11.74356  -13.55162 1.000 25.78871 ? 96  LEU   A C   1 
ATOM   77   O  O   . LEU   A 1 96  ? -4.11005  11.40240  -14.60483 1.000 19.30465 ? 96  LEU   A O   1 
ATOM   78   C  CB  . LEU   A 1 96  ? -5.93427  13.75704  -14.31142 1.000 17.45885 ? 96  LEU   A CB  1 
ATOM   79   C  CG  . LEU   A 1 96  ? -7.27380  14.25419  -14.85565 1.000 16.99135 ? 96  LEU   A CG  1 
ATOM   80   C  CD1 . LEU   A 1 96  ? -7.17755  15.69478  -15.32711 1.000 16.22201 ? 96  LEU   A CD1 1 
ATOM   81   C  CD2 . LEU   A 1 96  ? -7.74256  13.34905  -15.98525 1.000 18.89013 ? 96  LEU   A CD2 1 
ATOM   82   N  N   . GLU   A 1 97  ? -4.09307  11.55695  -12.35646 1.000 24.61326 ? 97  GLU   A N   1 
ATOM   83   C  CA  . GLU   A 1 97  ? -2.86502  10.78304  -12.22516 1.000 23.60467 ? 97  GLU   A CA  1 
ATOM   84   C  C   . GLU   A 1 97  ? -3.07403  9.30451   -12.52203 1.000 27.74973 ? 97  GLU   A C   1 
ATOM   85   O  O   . GLU   A 1 97  ? -2.08747  8.57788   -12.68260 1.000 18.82302 ? 97  GLU   A O   1 
ATOM   86   C  CB  . GLU   A 1 97  ? -2.28039  10.94392  -10.81904 1.000 29.40628 ? 97  GLU   A CB  1 
ATOM   87   C  CG  . GLU   A 1 97  ? -1.85008  12.36076  -10.47411 1.000 29.95432 ? 97  GLU   A CG  1 
ATOM   88   C  CD  . GLU   A 1 97  ? -1.44674  12.51285  -9.01731  1.000 31.43023 ? 97  GLU   A CD  1 
ATOM   89   O  OE1 . GLU   A 1 97  ? -1.15535  11.48788  -8.36537  1.000 30.43581 ? 97  GLU   A OE1 1 
ATOM   90   O  OE2 . GLU   A 1 97  ? -1.41956  13.66004  -8.52376  1.000 39.74907 ? 97  GLU   A OE2 1 
ATOM   91   N  N   . ASP   A 1 98  ? -4.32324  8.84719   -12.59438 1.000 22.49523 ? 98  ASP   A N   1 
ATOM   92   C  CA  . ASP   A 1 98  ? -4.65040  7.46044   -12.89507 1.000 22.96044 ? 98  ASP   A CA  1 
ATOM   93   C  C   . ASP   A 1 98  ? -4.89713  7.21707   -14.37929 1.000 19.35802 ? 98  ASP   A C   1 
ATOM   94   O  O   . ASP   A 1 98  ? -5.38190  6.14035   -14.74203 1.000 19.52234 ? 98  ASP   A O   1 
ATOM   95   C  CB  . ASP   A 1 98  ? -5.88751  7.02579   -12.10196 1.000 20.82473 ? 98  ASP   A CB  1 
ATOM   96   C  CG  . ASP   A 1 98  ? -5.64714  6.99754   -10.60814 1.000 25.41146 ? 98  ASP   A CG  1 
ATOM   97   O  OD1 . ASP   A 1 98  ? -4.47849  6.84528   -10.19614 1.000 24.49019 ? 98  ASP   A OD1 1 
ATOM   98   O  OD2 . ASP   A 1 98  ? -6.63038  7.12298   -9.84640  1.000 20.72950 ? 98  ASP   A OD2 1 
ATOM   99   N  N   . VAL   A 1 99  ? -4.56875  8.18341   -15.24205 1.000 18.98433 ? 99  VAL   A N   1 
ATOM   100  C  CA  . VAL   A 1 99  ? -4.94993  8.10885   -16.64980 1.000 14.77150 ? 99  VAL   A CA  1 
ATOM   101  C  C   . VAL   A 1 99  ? -4.32646  6.91145   -17.35717 1.000 16.04161 ? 99  VAL   A C   1 
ATOM   102  O  O   . VAL   A 1 99  ? -4.84445  6.46511   -18.38653 1.000 15.92330 ? 99  VAL   A O   1 
ATOM   103  C  CB  . VAL   A 1 99  ? -4.58547  9.43000   -17.36445 1.000 17.32717 ? 99  VAL   A CB  1 
ATOM   104  C  CG1 . VAL   A 1 99  ? -3.09564  9.48300   -17.67950 1.000 17.73397 ? 99  VAL   A CG1 1 
ATOM   105  C  CG2 . VAL   A 1 99  ? -5.42383  9.61124   -18.62535 1.000 20.14707 ? 99  VAL   A CG2 1 
ATOM   106  N  N   . ASN   A 1 100 ? -3.23108  6.37007   -16.82877 1.000 15.50739 ? 100 ASN   A N   1 
ATOM   107  C  CA  . ASN   A 1 100 ? -2.59572  5.19238   -17.40416 1.000 19.46885 ? 100 ASN   A CA  1 
ATOM   108  C  C   . ASN   A 1 100 ? -3.13971  3.88883   -16.83666 1.000 13.14157 ? 100 ASN   A C   1 
ATOM   109  O  O   . ASN   A 1 100 ? -2.63997  2.81827   -17.19731 1.000 19.66990 ? 100 ASN   A O   1 
ATOM   110  C  CB  . ASN   A 1 100 ? -1.07873  5.23956   -17.18273 1.000 12.09792 ? 100 ASN   A CB  1 
ATOM   111  C  CG  . ASN   A 1 100 ? -0.41868  6.41329   -17.87989 1.000 19.44327 ? 100 ASN   A CG  1 
ATOM   112  O  OD1 . ASN   A 1 100 ? -1.00858  7.04271   -18.75733 1.000 23.21747 ? 100 ASN   A OD1 1 
ATOM   113  N  ND2 . ASN   A 1 100 ? 0.82020   6.70661   -17.49777 1.000 25.39385 ? 100 ASN   A ND2 1 
ATOM   114  N  N   . LYS   A 1 101 ? -4.14069  3.94690   -15.96397 1.000 17.16671 ? 101 LYS   A N   1 
ATOM   115  C  CA  . LYS   A 1 101 ? -4.63197  2.77284   -15.25912 1.000 15.67473 ? 101 LYS   A CA  1 
ATOM   116  C  C   . LYS   A 1 101 ? -6.00732  2.36322   -15.76729 1.000 16.27613 ? 101 LYS   A C   1 
ATOM   117  O  O   . LYS   A 1 101 ? -6.88913  3.20651   -15.96415 1.000 13.69163 ? 101 LYS   A O   1 
ATOM   118  C  CB  . LYS   A 1 101 ? -4.71031  3.02406   -13.75053 1.000 16.94770 ? 101 LYS   A CB  1 
ATOM   119  C  CG  . LYS   A 1 101 ? -3.39361  3.39106   -13.08969 1.000 22.38163 ? 101 LYS   A CG  1 
ATOM   120  C  CD  . LYS   A 1 101 ? -3.47218  3.12875   -11.59320 1.000 28.22318 ? 101 LYS   A CD  1 
ATOM   121  C  CE  . LYS   A 1 101 ? -2.67399  4.14346   -10.79011 1.000 35.57377 ? 101 LYS   A CE  1 
ATOM   122  N  NZ  . LYS   A 1 101 ? -1.20580  4.02256   -10.99823 1.000 34.33643 ? 101 LYS   A NZ  1 
ATOM   123  N  N   . TRP   A 1 102 ? -6.17410  1.05963   -15.97575 1.000 17.50900 ? 102 TRP   A N   1 
ATOM   124  C  CA  . TRP   A 1 102 ? -7.49375  0.47952   -16.17701 1.000 18.10069 ? 102 TRP   A CA  1 
ATOM   125  C  C   . TRP   A 1 102 ? -8.35582  0.75560   -14.95258 1.000 19.99168 ? 102 TRP   A C   1 
ATOM   126  O  O   . TRP   A 1 102 ? -7.90725  0.59330   -13.81373 1.000 22.97604 ? 102 TRP   A O   1 
ATOM   127  C  CB  . TRP   A 1 102 ? -7.35903  -1.02698  -16.40915 1.000 15.71977 ? 102 TRP   A CB  1 
ATOM   128  C  CG  . TRP   A 1 102 ? -8.40837  -1.66748  -17.28151 1.000 15.24664 ? 102 TRP   A CG  1 
ATOM   129  C  CD1 . TRP   A 1 102 ? -9.36387  -2.56477  -16.89266 1.000 14.55231 ? 102 TRP   A CD1 1 
ATOM   130  C  CD2 . TRP   A 1 102 ? -8.57659  -1.49207  -18.69471 1.000 11.44336 ? 102 TRP   A CD2 1 
ATOM   131  N  NE1 . TRP   A 1 102 ? -10.12379 -2.94625  -17.97365 1.000 11.47327 ? 102 TRP   A NE1 1 
ATOM   132  C  CE2 . TRP   A 1 102 ? -9.65920  -2.30392  -19.09160 1.000 12.89618 ? 102 TRP   A CE2 1 
ATOM   133  C  CE3 . TRP   A 1 102 ? -7.92114  -0.72286  -19.66157 1.000 15.95681 ? 102 TRP   A CE3 1 
ATOM   134  C  CZ2 . TRP   A 1 102 ? -10.10377 -2.36323  -20.41309 1.000 11.58753 ? 102 TRP   A CZ2 1 
ATOM   135  C  CZ3 . TRP   A 1 102 ? -8.36356  -0.78487  -20.97360 1.000 11.10884 ? 102 TRP   A CZ3 1 
ATOM   136  C  CH2 . TRP   A 1 102 ? -9.44331  -1.59864  -21.33643 1.000 10.69615 ? 102 TRP   A CH2 1 
ATOM   137  N  N   . GLY   A 1 103 ? -9.59040  1.18825   -15.18261 1.000 15.37761 ? 103 GLY   A N   1 
ATOM   138  C  CA  . GLY   A 1 103 ? -10.46677 1.49069   -14.07250 1.000 16.75353 ? 103 GLY   A CA  1 
ATOM   139  C  C   . GLY   A 1 103 ? -10.28860 2.86163   -13.46682 1.000 20.41176 ? 103 GLY   A C   1 
ATOM   140  O  O   . GLY   A 1 103 ? -10.74290 3.08179   -12.33729 1.000 26.19628 ? 103 GLY   A O   1 
ATOM   141  N  N   . LEU   A 1 104 ? -9.59872  3.77031   -14.15859 1.000 18.24843 ? 104 LEU   A N   1 
ATOM   142  C  CA  . LEU   A 1 104 ? -9.72030  5.19586   -13.88956 1.000 16.99135 ? 104 LEU   A CA  1 
ATOM   143  C  C   . LEU   A 1 104 ? -11.17594 5.53800   -13.61133 1.000 18.38781 ? 104 LEU   A C   1 
ATOM   144  O  O   . LEU   A 1 104 ? -12.07638 5.03263   -14.28482 1.000 20.71037 ? 104 LEU   A O   1 
ATOM   145  C  CB  . LEU   A 1 104 ? -9.22995  5.98779   -15.10449 1.000 14.64071 ? 104 LEU   A CB  1 
ATOM   146  C  CG  . LEU   A 1 104 ? -9.52438  7.48656   -15.10754 1.000 15.69005 ? 104 LEU   A CG  1 
ATOM   147  C  CD1 . LEU   A 1 104 ? -8.41768  8.21447   -14.38183 1.000 17.22393 ? 104 LEU   A CD1 1 
ATOM   148  C  CD2 . LEU   A 1 104 ? -9.71758  8.03517   -16.51512 1.000 16.79713 ? 104 LEU   A CD2 1 
ATOM   149  N  N   . HIS   A 1 105 ? -11.42358 6.38348   -12.60956 1.000 17.49035 ? 105 HIS   A N   1 
ATOM   150  C  CA  . HIS   A 1 105 ? -12.81318 6.72713   -12.31082 1.000 22.74441 ? 105 HIS   A CA  1 
ATOM   151  C  C   . HIS   A 1 105 ? -13.26734 7.86307   -13.22269 1.000 18.47220 ? 105 HIS   A C   1 
ATOM   152  O  O   . HIS   A 1 105 ? -13.30486 9.04041   -12.85461 1.000 18.60226 ? 105 HIS   A O   1 
ATOM   153  C  CB  . HIS   A 1 105 ? -13.03055 7.08172   -10.85082 1.000 25.45049 ? 105 HIS   A CB  1 
ATOM   154  C  CG  . HIS   A 1 105 ? -14.45365 6.89478   -10.44275 1.000 35.24351 ? 105 HIS   A CG  1 
ATOM   155  N  ND1 . HIS   A 1 105 ? -15.50060 7.37555   -11.19726 1.000 21.66803 ? 105 HIS   A ND1 1 
ATOM   156  C  CD2 . HIS   A 1 105 ? -15.01162 6.24620   -9.39661  1.000 37.19796 ? 105 HIS   A CD2 1 
ATOM   157  C  CE1 . HIS   A 1 105 ? -16.64328 7.03736   -10.62929 1.000 24.07857 ? 105 HIS   A CE1 1 
ATOM   158  N  NE2 . HIS   A 1 105 ? -16.37543 6.35032   -9.53433  1.000 45.23832 ? 105 HIS   A NE2 1 
ATOM   159  N  N   . VAL   A 1 106 ? -13.67510 7.47537   -14.43001 1.000 18.08056 ? 106 VAL   A N   1 
ATOM   160  C  CA  . VAL   A 1 106 ? -14.07583 8.45109   -15.43382 1.000 13.79090 ? 106 VAL   A CA  1 
ATOM   161  C  C   . VAL   A 1 106 ? -15.31647 9.23254   -14.99815 1.000 15.65832 ? 106 VAL   A C   1 
ATOM   162  O  O   . VAL   A 1 106 ? -15.49328 10.38964  -15.39708 1.000 11.52926 ? 106 VAL   A O   1 
ATOM   163  C  CB  . VAL   A 1 106 ? -14.28417 7.73103   -16.77848 1.000 14.50115 ? 106 VAL   A CB  1 
ATOM   164  C  CG1 . VAL   A 1 106 ? -15.46699 6.77794   -16.69134 1.000 11.38028 ? 106 VAL   A CG1 1 
ATOM   165  C  CG2 . VAL   A 1 106 ? -14.44609 8.73045   -17.91439 1.000 16.13184 ? 106 VAL   A CG2 1 
ATOM   166  N  N   . PHE   A 1 107 ? -16.18303 8.64135   -14.16651 1.000 14.42646 ? 107 PHE   A N   1 
ATOM   167  C  CA  . PHE   A 1 107 ? -17.39940 9.34643   -13.76258 1.000 16.93374 ? 107 PHE   A CA  1 
ATOM   168  C  C   . PHE   A 1 107 ? -17.09471 10.46570  -12.77345 1.000 16.35379 ? 107 PHE   A C   1 
ATOM   169  O  O   . PHE   A 1 107 ? -17.69500 11.54480  -12.84692 1.000 13.31781 ? 107 PHE   A O   1 
ATOM   170  C  CB  . PHE   A 1 107 ? -18.41597 8.36661   -13.17682 1.000 14.40176 ? 107 PHE   A CB  1 
ATOM   171  C  CG  . PHE   A 1 107 ? -18.91403 7.36035   -14.16753 1.000 13.09283 ? 107 PHE   A CG  1 
ATOM   172  C  CD1 . PHE   A 1 107 ? -19.82166 7.72822   -15.14694 1.000 16.78243 ? 107 PHE   A CD1 1 
ATOM   173  C  CD2 . PHE   A 1 107 ? -18.47012 6.04931   -14.12684 1.000 17.91423 ? 107 PHE   A CD2 1 
ATOM   174  C  CE1 . PHE   A 1 107 ? -20.27781 6.80810   -16.06849 1.000 17.30139 ? 107 PHE   A CE1 1 
ATOM   175  C  CE2 . PHE   A 1 107 ? -18.92345 5.12195   -15.04359 1.000 13.34172 ? 107 PHE   A CE2 1 
ATOM   176  C  CZ  . PHE   A 1 107 ? -19.82444 5.50309   -16.01976 1.000 16.19778 ? 107 PHE   A CZ  1 
ATOM   177  N  N   . ARG   A 1 108 ? -16.17280 10.23061  -11.83698 1.000 13.41046 ? 108 ARG   A N   1 
ATOM   178  C  CA  . ARG   A 1 108 ? -15.73354 11.31345  -10.96282 1.000 18.93994 ? 108 ARG   A CA  1 
ATOM   179  C  C   . ARG   A 1 108 ? -15.05647 12.41632  -11.76110 1.000 13.75614 ? 108 ARG   A C   1 
ATOM   180  O  O   . ARG   A 1 108 ? -15.28746 13.60520  -11.51363 1.000 17.95964 ? 108 ARG   A O   1 
ATOM   181  C  CB  . ARG   A 1 108 ? -14.78264 10.78520  -9.89341  1.000 21.79805 ? 108 ARG   A CB  1 
ATOM   182  C  CG  . ARG   A 1 108 ? -15.42734 9.89010   -8.86746  1.000 27.89422 ? 108 ARG   A CG  1 
ATOM   183  C  CD  . ARG   A 1 108 ? -14.47546 9.66026   -7.71630  1.000 33.66929 ? 108 ARG   A CD  1 
ATOM   184  N  NE  . ARG   A 1 108 ? -14.81614 8.46004   -6.96565  1.000 34.99728 ? 108 ARG   A NE  1 
ATOM   185  C  CZ  . ARG   A 1 108 ? -13.92479 7.70807   -6.33266  1.000 31.49954 ? 108 ARG   A CZ  1 
ATOM   186  N  NH1 . ARG   A 1 108 ? -12.63976 8.03570   -6.36508  1.000 22.10698 ? 108 ARG   A NH1 1 
ATOM   187  N  NH2 . ARG   A 1 108 ? -14.31650 6.62772   -5.67219  1.000 33.40658 ? 108 ARG   A NH2 1 
ATOM   188  N  N   . ILE   A 1 109 ? -14.21043 12.03767  -12.72060 1.000 13.44945 ? 109 ILE   A N   1 
ATOM   189  C  CA  . ILE   A 1 109 ? -13.54798 13.02292  -13.56866 1.000 14.58695 ? 109 ILE   A CA  1 
ATOM   190  C  C   . ILE   A 1 109 ? -14.57743 13.83346  -14.34448 1.000 14.18624 ? 109 ILE   A C   1 
ATOM   191  O  O   . ILE   A 1 109 ? -14.40231 15.03750  -14.56895 1.000 13.10803 ? 109 ILE   A O   1 
ATOM   192  C  CB  . ILE   A 1 109 ? -12.54039 12.32018  -14.49736 1.000 13.60818 ? 109 ILE   A CB  1 
ATOM   193  C  CG1 . ILE   A 1 109 ? -11.26851 11.98247  -13.71797 1.000 12.04809 ? 109 ILE   A CG1 1 
ATOM   194  C  CG2 . ILE   A 1 109 ? -12.22901 13.16524  -15.72596 1.000 12.17011 ? 109 ILE   A CG2 1 
ATOM   195  C  CD1 . ILE   A 1 109 ? -10.31751 11.11360  -14.46852 1.000 18.54468 ? 109 ILE   A CD1 1 
ATOM   196  N  N   . ALA   A 1 110 ? -15.67874 13.19360  -14.74259 1.000 14.06174 ? 110 ALA   A N   1 
ATOM   197  C  CA  . ALA   A 1 110 ? -16.74737 13.90980  -15.43052 1.000 13.39967 ? 110 ALA   A CA  1 
ATOM   198  C  C   . ALA   A 1 110 ? -17.33170 15.00470  -14.54501 1.000 14.40027 ? 110 ALA   A C   1 
ATOM   199  O  O   . ALA   A 1 110 ? -17.54106 16.13709  -14.99449 1.000 18.47412 ? 110 ALA   A O   1 
ATOM   200  C  CB  . ALA   A 1 110 ? -17.83267 12.92780  -15.87098 1.000 14.73998 ? 110 ALA   A CB  1 
ATOM   201  N  N   . GLU   A 1 111 ? -17.59436 14.68649  -13.27502 1.000 13.68431 ? 111 GLU   A N   1 
ATOM   202  C  CA  . GLU   A 1 111 ? -18.12190 15.68991  -12.35488 1.000 21.58270 ? 111 GLU   A CA  1 
ATOM   203  C  C   . GLU   A 1 111 ? -17.07427 16.74951  -12.03774 1.000 20.01248 ? 111 GLU   A C   1 
ATOM   204  O  O   . GLU   A 1 111 ? -17.35180 17.95265  -12.10540 1.000 20.44051 ? 111 GLU   A O   1 
ATOM   205  C  CB  . GLU   A 1 111 ? -18.60311 15.02741  -11.06396 1.000 26.39017 ? 111 GLU   A CB  1 
ATOM   206  C  CG  . GLU   A 1 111 ? -19.63293 13.93132  -11.24044 1.000 36.69554 ? 111 GLU   A CG  1 
ATOM   207  C  CD  . GLU   A 1 111 ? -20.02350 13.30940  -9.91492  1.000 50.30195 ? 111 GLU   A CD  1 
ATOM   208  O  OE1 . GLU   A 1 111 ? -21.05605 12.60865  -9.86033  1.000 46.77531 ? 111 GLU   A OE1 1 
ATOM   209  O  OE2 . GLU   A 1 111 ? -19.29525 13.52996  -8.92368  1.000 51.33649 ? 111 GLU   A OE2 1 
ATOM   210  N  N   . LEU   A 1 112 ? -15.86027 16.31573  -11.68789 1.000 16.97778 ? 112 LEU   A N   1 
ATOM   211  C  CA  . LEU   A 1 112 ? -14.81273 17.23751  -11.26229 1.000 21.67309 ? 112 LEU   A CA  1 
ATOM   212  C  C   . LEU   A 1 112 ? -14.40676 18.21610  -12.35661 1.000 23.14640 ? 112 LEU   A C   1 
ATOM   213  O  O   . LEU   A 1 112 ? -13.87843 19.28916  -12.04547 1.000 21.64183 ? 112 LEU   A O   1 
ATOM   214  C  CB  . LEU   A 1 112 ? -13.59174 16.44499  -10.79349 1.000 18.25949 ? 112 LEU   A CB  1 
ATOM   215  C  CG  . LEU   A 1 112 ? -13.80897 15.61380  -9.52891  1.000 20.69618 ? 112 LEU   A CG  1 
ATOM   216  C  CD1 . LEU   A 1 112 ? -12.68220 14.61297  -9.34581  1.000 18.26202 ? 112 LEU   A CD1 1 
ATOM   217  C  CD2 . LEU   A 1 112 ? -13.93004 16.52093  -8.31530  1.000 23.75725 ? 112 LEU   A CD2 1 
ATOM   218  N  N   . SER   A 1 113 ? -14.64167 17.87881  -13.62304 1.000 18.99708 ? 113 SER   A N   1 
ATOM   219  C  CA  . SER   A 1 113 ? -14.24841 18.72017  -14.74467 1.000 20.54583 ? 113 SER   A CA  1 
ATOM   220  C  C   . SER   A 1 113 ? -15.38481 19.59342  -15.26089 1.000 18.35872 ? 113 SER   A C   1 
ATOM   221  O  O   . SER   A 1 113 ? -15.24056 20.21520  -16.31820 1.000 19.14992 ? 113 SER   A O   1 
ATOM   222  C  CB  . SER   A 1 113 ? -13.70672 17.85449  -15.88388 1.000 19.29416 ? 113 SER   A CB  1 
ATOM   223  O  OG  . SER   A 1 113 ? -14.71049 16.98262  -16.37481 1.000 17.86650 ? 113 SER   A OG  1 
ATOM   224  N  N   . GLY   A 1 114 ? -16.50183 19.66210  -14.54521 1.000 22.63999 ? 114 GLY   A N   1 
ATOM   225  C  CA  . GLY   A 1 114 ? -17.65271 20.38945  -15.05312 1.000 21.57466 ? 114 GLY   A CA  1 
ATOM   226  C  C   . GLY   A 1 114 ? -18.25188 19.75697  -16.29069 1.000 23.08752 ? 114 GLY   A C   1 
ATOM   227  O  O   . GLY   A 1 114 ? -18.57782 20.46793  -17.25118 1.000 25.48542 ? 114 GLY   A O   1 
ATOM   228  N  N   . ASN   A 1 115 ? -18.40208 18.43058  -16.28697 1.000 21.78195 ? 115 ASN   A N   1 
ATOM   229  C  CA  . ASN   A 1 115 ? -18.89119 17.66952  -17.43758 1.000 21.91491 ? 115 ASN   A CA  1 
ATOM   230  C  C   . ASN   A 1 115 ? -17.99316 17.87144  -18.65549 1.000 19.21720 ? 115 ASN   A C   1 
ATOM   231  O  O   . ASN   A 1 115 ? -18.46563 18.00913  -19.78544 1.000 19.45854 ? 115 ASN   A O   1 
ATOM   232  C  CB  . ASN   A 1 115 ? -20.34560 18.01488  -17.76640 1.000 22.76317 ? 115 ASN   A CB  1 
ATOM   233  C  CG  . ASN   A 1 115 ? -21.01926 16.94945  -18.61144 1.000 26.37494 ? 115 ASN   A CG  1 
ATOM   234  O  OD1 . ASN   A 1 115 ? -20.56781 15.80492  -18.66450 1.000 25.99698 ? 115 ASN   A OD1 1 
ATOM   235  N  ND2 . ASN   A 1 115 ? -22.10393 17.32223  -19.27882 1.000 17.53908 ? 115 ASN   A ND2 1 
ATOM   236  N  N   . ARG   A 1 116 ? -16.68225 17.88095  -18.42645 1.000 18.64710 ? 116 ARG   A N   1 
ATOM   237  C  CA  . ARG   A 1 116 ? -15.74245 17.88485  -19.53974 1.000 17.92361 ? 116 ARG   A CA  1 
ATOM   238  C  C   . ARG   A 1 116 ? -14.76581 16.71515  -19.45375 1.000 12.83565 ? 116 ARG   A C   1 
ATOM   239  O  O   . ARG   A 1 116 ? -13.55317 16.92821  -19.58180 1.000 11.70714 ? 116 ARG   A O   1 
ATOM   240  C  CB  . ARG   A 1 116 ? -14.96764 19.20455  -19.58044 1.000 13.61399 ? 116 ARG   A CB  1 
ATOM   241  C  CG  . ARG   A 1 116 ? -15.83022 20.42648  -19.83026 1.000 17.58893 ? 116 ARG   A CG  1 
ATOM   242  C  CD  . ARG   A 1 116 ? -16.31116 20.46055  -21.26921 1.000 21.11388 ? 116 ARG   A CD  1 
ATOM   243  N  NE  . ARG   A 1 116 ? -16.98818 21.71153  -21.59308 1.000 33.50703 ? 116 ARG   A NE  1 
ATOM   244  C  CZ  . ARG   A 1 116 ? -17.43407 22.01835  -22.80544 1.000 34.94670 ? 116 ARG   A CZ  1 
ATOM   245  N  NH1 . ARG   A 1 116 ? -17.26364 21.16485  -23.80527 1.000 24.30111 ? 116 ARG   A NH1 1 
ATOM   246  N  NH2 . ARG   A 1 116 ? -18.04233 23.17739  -23.02116 1.000 33.73519 ? 116 ARG   A NH2 1 
ATOM   247  N  N   . PRO   A 1 117 ? -15.23210 15.47223  -19.25549 1.000 12.61195 ? 117 PRO   A N   1 
ATOM   248  C  CA  . PRO   A 1 117 ? -14.26821 14.36509  -19.15309 1.000 12.39223 ? 117 PRO   A CA  1 
ATOM   249  C  C   . PRO   A 1 117 ? -13.48636 14.13611  -20.43138 1.000 12.29566 ? 117 PRO   A C   1 
ATOM   250  O  O   . PRO   A 1 117 ? -12.29779 13.80399  -20.36940 1.000 12.99048 ? 117 PRO   A O   1 
ATOM   251  C  CB  . PRO   A 1 117 ? -15.15761 13.16389  -18.80360 1.000 14.86391 ? 117 PRO   A CB  1 
ATOM   252  C  CG  . PRO   A 1 117 ? -16.46791 13.49638  -19.40785 1.000 12.29084 ? 117 PRO   A CG  1 
ATOM   253  C  CD  . PRO   A 1 117 ? -16.61983 14.97285  -19.19369 1.000 13.60979 ? 117 PRO   A CD  1 
ATOM   254  N  N   . LEU   A 1 118 ? -14.11644 14.31705  -21.59390 1.000 10.74162 ? 118 LEU   A N   1 
ATOM   255  C  CA  . LEU   A 1 118 ? -13.42130 14.06950  -22.85231 1.000 12.01191 ? 118 LEU   A CA  1 
ATOM   256  C  C   . LEU   A 1 118 ? -12.31381 15.09076  -23.07934 1.000 12.16135 ? 118 LEU   A C   1 
ATOM   257  O  O   . LEU   A 1 118 ? -11.20067 14.73200  -23.47841 1.000 10.73937 ? 118 LEU   A O   1 
ATOM   258  C  CB  . LEU   A 1 118 ? -14.41273 14.07886  -24.01567 1.000 9.05497  ? 118 LEU   A CB  1 
ATOM   259  C  CG  . LEU   A 1 118 ? -13.80789 13.74144  -25.38001 1.000 10.09724 ? 118 LEU   A CG  1 
ATOM   260  C  CD1 . LEU   A 1 118 ? -13.30241 12.30560  -25.40204 1.000 11.99945 ? 118 LEU   A CD1 1 
ATOM   261  C  CD2 . LEU   A 1 118 ? -14.81513 13.97678  -26.49310 1.000 10.17156 ? 118 LEU   A CD2 1 
ATOM   262  N  N   . THR   A 1 119 ? -12.59770 16.37042  -22.82522 1.000 9.61356  ? 119 THR   A N   1 
ATOM   263  C  CA  . THR   A 1 119 ? -11.58303 17.40209  -23.02018 1.000 12.11711 ? 119 THR   A CA  1 
ATOM   264  C  C   . THR   A 1 119 ? -10.38184 17.17433  -22.10964 1.000 11.35301 ? 119 THR   A C   1 
ATOM   265  O  O   . THR   A 1 119 ? -9.23575  17.14330  -22.57240 1.000 13.32456 ? 119 THR   A O   1 
ATOM   266  C  CB  . THR   A 1 119 ? -12.17715 18.79059  -22.77690 1.000 14.19121 ? 119 THR   A CB  1 
ATOM   267  O  OG1 . THR   A 1 119 ? -13.15114 19.08542  -23.78694 1.000 13.82126 ? 119 THR   A OG1 1 
ATOM   268  C  CG2 . THR   A 1 119 ? -11.07924 19.84616  -22.81031 1.000 15.11629 ? 119 THR   A CG2 1 
ATOM   269  N  N   . VAL   A 1 120 ? -10.62559 17.00085  -20.80753 1.000 12.46751 ? 120 VAL   A N   1 
ATOM   270  C  CA  . VAL   A 1 120 ? -9.51612  16.93032  -19.86080 1.000 13.65641 ? 120 VAL   A CA  1 
ATOM   271  C  C   . VAL   A 1 120 ? -8.74599  15.62200  -20.00666 1.000 15.58698 ? 120 VAL   A C   1 
ATOM   272  O  O   . VAL   A 1 120 ? -7.52082  15.59779  -19.83788 1.000 13.06718 ? 120 VAL   A O   1 
ATOM   273  C  CB  . VAL   A 1 120 ? -10.01939 17.13630  -18.41776 1.000 17.00110 ? 120 VAL   A CB  1 
ATOM   274  C  CG1 . VAL   A 1 120 ? -10.71609 18.48464  -18.28335 1.000 14.01583 ? 120 VAL   A CG1 1 
ATOM   275  C  CG2 . VAL   A 1 120 ? -10.94454 16.00529  -17.99099 1.000 13.34069 ? 120 VAL   A CG2 1 
ATOM   276  N  N   . ILE   A 1 121 ? -9.42949  14.52135  -20.32965 1.000 11.10045 ? 121 ILE   A N   1 
ATOM   277  C  CA  . ILE   A 1 121 ? -8.73415  13.24516  -20.46794 1.000 11.52203 ? 121 ILE   A CA  1 
ATOM   278  C  C   . ILE   A 1 121 ? -7.91877  13.21832  -21.75477 1.000 11.57221 ? 121 ILE   A C   1 
ATOM   279  O  O   . ILE   A 1 121 ? -6.77391  12.74978  -21.76830 1.000 15.95677 ? 121 ILE   A O   1 
ATOM   280  C  CB  . ILE   A 1 121 ? -9.73441  12.07648  -20.39176 1.000 15.29513 ? 121 ILE   A CB  1 
ATOM   281  C  CG1 . ILE   A 1 121 ? -10.09986 11.79335  -18.93133 1.000 12.02788 ? 121 ILE   A CG1 1 
ATOM   282  C  CG2 . ILE   A 1 121 ? -9.17386  10.83225  -21.07212 1.000 11.00563 ? 121 ILE   A CG2 1 
ATOM   283  C  CD1 . ILE   A 1 121 ? -11.28120 10.85700  -18.75714 1.000 14.99578 ? 121 ILE   A CD1 1 
ATOM   284  N  N   . MET   A 1 122 ? -8.48569  13.72630  -22.85234 1.000 12.48770 ? 122 MET   A N   1 
ATOM   285  C  CA  . MET   A 1 122 ? -7.72617  13.83700  -24.09518 1.000 10.80620 ? 122 MET   A CA  1 
ATOM   286  C  C   . MET   A 1 122 ? -6.51709  14.74705  -23.91771 1.000 13.90042 ? 122 MET   A C   1 
ATOM   287  O  O   . MET   A 1 122 ? -5.40551  14.41229  -24.34334 1.000 13.69700 ? 122 MET   A O   1 
ATOM   288  C  CB  . MET   A 1 122 ? -8.62397  14.35412  -25.22026 1.000 12.83325 ? 122 MET   A CB  1 
ATOM   289  C  CG  . MET   A 1 122 ? -9.52462  13.30368  -25.85111 1.000 13.39636 ? 122 MET   A CG  1 
ATOM   290  S  SD  . MET   A 1 122 ? -8.64654  12.25759  -27.02772 1.000 13.86315 ? 122 MET   A SD  1 
ATOM   291  C  CE  . MET   A 1 122 ? -8.57151  13.33911  -28.45321 1.000 10.73743 ? 122 MET   A CE  1 
ATOM   292  N  N   . HIS   A 1 123 ? -6.71875  15.90900  -23.29088 1.000 13.12280 ? 123 HIS   A N   1 
ATOM   293  C  CA  . HIS   A 1 123 ? -5.61104  16.82939  -23.05077 1.000 16.80265 ? 123 HIS   A CA  1 
ATOM   294  C  C   . HIS   A 1 123 ? -4.53077  16.17419  -22.20025 1.000 15.04057 ? 123 HIS   A C   1 
ATOM   295  O  O   . HIS   A 1 123 ? -3.33630  16.27608  -22.50414 1.000 14.87721 ? 123 HIS   A O   1 
ATOM   296  C  CB  . HIS   A 1 123 ? -6.12404  18.10292  -22.37803 1.000 18.72350 ? 123 HIS   A CB  1 
ATOM   297  C  CG  . HIS   A 1 123 ? -5.04437  19.08361  -22.04126 1.000 24.32257 ? 123 HIS   A CG  1 
ATOM   298  N  ND1 . HIS   A 1 123 ? -4.26560  19.69070  -23.00267 1.000 27.50960 ? 123 HIS   A ND1 1 
ATOM   299  C  CD2 . HIS   A 1 123 ? -4.61110  19.56030  -20.85007 1.000 32.96528 ? 123 HIS   A CD2 1 
ATOM   300  C  CE1 . HIS   A 1 123 ? -3.40031  20.50037  -22.41895 1.000 29.79394 ? 123 HIS   A CE1 1 
ATOM   301  N  NE2 . HIS   A 1 123 ? -3.58903  20.43997  -21.11300 1.000 39.86730 ? 123 HIS   A NE2 1 
ATOM   302  N  N   . THR   A 1 124 ? -4.93829  15.49451  -21.12499 1.000 14.38309 ? 124 THR   A N   1 
ATOM   303  C  CA  . THR   A 1 124 ? -3.98119  14.78939  -20.27819 1.000 16.72780 ? 124 THR   A CA  1 
ATOM   304  C  C   . THR   A 1 124 ? -3.20120  13.74971  -21.07295 1.000 14.98215 ? 124 THR   A C   1 
ATOM   305  O  O   . THR   A 1 124 ? -1.97860  13.63406  -20.92764 1.000 18.78284 ? 124 THR   A O   1 
ATOM   306  C  CB  . THR   A 1 124 ? -4.70814  14.12795  -19.10540 1.000 16.62033 ? 124 THR   A CB  1 
ATOM   307  O  OG1 . THR   A 1 124 ? -5.32957  15.13347  -18.29537 1.000 13.97343 ? 124 THR   A OG1 1 
ATOM   308  C  CG2 . THR   A 1 124 ? -3.73649  13.32510  -18.25174 1.000 16.84508 ? 124 THR   A CG2 1 
ATOM   309  N  N   . ILE   A 1 125 ? -3.88983  12.99499  -21.93108 1.000 15.67448 ? 125 ILE   A N   1 
ATOM   310  C  CA  . ILE   A 1 125 ? -3.23448  11.92443  -22.67596 1.000 15.89023 ? 125 ILE   A CA  1 
ATOM   311  C  C   . ILE   A 1 125 ? -2.29642  12.49481  -23.73445 1.000 14.12612 ? 125 ILE   A C   1 
ATOM   312  O  O   . ILE   A 1 125 ? -1.18500  11.98818  -23.93247 1.000 16.40845 ? 125 ILE   A O   1 
ATOM   313  C  CB  . ILE   A 1 125 ? -4.29224  10.98456  -23.28266 1.000 13.67026 ? 125 ILE   A CB  1 
ATOM   314  C  CG1 . ILE   A 1 125 ? -4.87021  10.08200  -22.19201 1.000 19.28523 ? 125 ILE   A CG1 1 
ATOM   315  C  CG2 . ILE   A 1 125 ? -3.70548  10.15353  -24.41290 1.000 13.92119 ? 125 ILE   A CG2 1 
ATOM   316  C  CD1 . ILE   A 1 125 ? -6.10474  9.33226   -22.61362 1.000 15.06032 ? 125 ILE   A CD1 1 
ATOM   317  N  N   . PHE   A 1 126 ? -2.71931  13.55751  -24.42609 1.000 17.16349 ? 126 PHE   A N   1 
ATOM   318  C  CA  . PHE   A 1 126 ? -1.84280  14.19474  -25.40617 1.000 17.43749 ? 126 PHE   A CA  1 
ATOM   319  C  C   . PHE   A 1 126 ? -0.57784  14.73453  -24.74749 1.000 17.96731 ? 126 PHE   A C   1 
ATOM   320  O  O   . PHE   A 1 126 ? 0.52087   14.61157  -25.30264 1.000 15.30658 ? 126 PHE   A O   1 
ATOM   321  C  CB  . PHE   A 1 126 ? -2.59021  15.30999  -26.13917 1.000 16.56282 ? 126 PHE   A CB  1 
ATOM   322  C  CG  . PHE   A 1 126 ? -3.36364  14.83712  -27.34088 1.000 15.21900 ? 126 PHE   A CG  1 
ATOM   323  C  CD1 . PHE   A 1 126 ? -4.36615  13.88965  -27.21068 1.000 13.38796 ? 126 PHE   A CD1 1 
ATOM   324  C  CD2 . PHE   A 1 126 ? -3.08932  15.34583  -28.60124 1.000 13.40009 ? 126 PHE   A CD2 1 
ATOM   325  C  CE1 . PHE   A 1 126 ? -5.07715  13.45397  -28.31371 1.000 9.91649  ? 126 PHE   A CE1 1 
ATOM   326  C  CE2 . PHE   A 1 126 ? -3.79752  14.91561  -29.70910 1.000 12.37075 ? 126 PHE   A CE2 1 
ATOM   327  C  CZ  . PHE   A 1 126 ? -4.79364  13.96769  -29.56475 1.000 8.51327  ? 126 PHE   A CZ  1 
ATOM   328  N  N   . GLN   A 1 127 ? -0.71180  15.33519  -23.56127 1.000 20.34758 ? 127 GLN   A N   1 
ATOM   329  C  CA  . GLN   A 1 127 ? 0.46706   15.75744  -22.81044 1.000 21.29298 ? 127 GLN   A CA  1 
ATOM   330  C  C   . GLN   A 1 127 ? 1.30711   14.55993  -22.38772 1.000 20.49926 ? 127 GLN   A C   1 
ATOM   331  O  O   . GLN   A 1 127 ? 2.53752   14.57986  -22.51094 1.000 19.49380 ? 127 GLN   A O   1 
ATOM   332  C  CB  . GLN   A 1 127 ? 0.05332   16.56848  -21.58107 1.000 22.98635 ? 127 GLN   A CB  1 
ATOM   333  C  CG  . GLN   A 1 127 ? -0.50085  17.95291  -21.88278 1.000 28.16410 ? 127 GLN   A CG  1 
ATOM   334  C  CD  . GLN   A 1 127 ? 0.56360   18.91986  -22.37458 1.000 40.36177 ? 127 GLN   A CD  1 
ATOM   335  O  OE1 . GLN   A 1 127 ? 1.75709   18.61716  -22.34635 1.000 35.89586 ? 127 GLN   A OE1 1 
ATOM   336  N  NE2 . GLN   A 1 127 ? 0.13344   20.09326  -22.82647 1.000 32.30588 ? 127 GLN   A NE2 1 
ATOM   337  N  N   . GLU   A 1 128 ? 0.65615   13.50689  -21.88496 1.000 19.89120 ? 128 GLU   A N   1 
ATOM   338  C  CA  . GLU   A 1 128 ? 1.38415   12.33790  -21.40274 1.000 20.46017 ? 128 GLU   A CA  1 
ATOM   339  C  C   . GLU   A 1 128 ? 2.18835   11.68816  -22.52354 1.000 19.38700 ? 128 GLU   A C   1 
ATOM   340  O  O   . GLU   A 1 128 ? 3.30809   11.21489  -22.30061 1.000 19.81748 ? 128 GLU   A O   1 
ATOM   341  C  CB  . GLU   A 1 128 ? 0.40777   11.33231  -20.78831 1.000 21.76250 ? 128 GLU   A CB  1 
ATOM   342  C  CG  . GLU   A 1 128 ? 1.04102   10.02605  -20.32293 1.000 22.72495 ? 128 GLU   A CG  1 
ATOM   343  C  CD  . GLU   A 1 128 ? 1.78944   10.16324  -19.00975 1.000 27.16743 ? 128 GLU   A CD  1 
ATOM   344  O  OE1 . GLU   A 1 128 ? 2.27463   9.13421   -18.49434 1.000 33.11154 ? 128 GLU   A OE1 1 
ATOM   345  O  OE2 . GLU   A 1 128 ? 1.88823   11.29394  -18.48802 1.000 24.15225 ? 128 GLU   A OE2 1 
ATOM   346  N  N   . ARG   A 1 129 ? 1.65409   11.68499  -23.74431 1.000 17.55887 ? 129 ARG   A N   1 
ATOM   347  C  CA  . ARG   A 1 129 ? 2.30031   11.00967  -24.86312 1.000 16.82989 ? 129 ARG   A CA  1 
ATOM   348  C  C   . ARG   A 1 129 ? 3.16267   11.93109  -25.73214 1.000 16.46274 ? 129 ARG   A C   1 
ATOM   349  O  O   . ARG   A 1 129 ? 3.51234   11.53559  -26.85491 1.000 15.42424 ? 129 ARG   A O   1 
ATOM   350  C  CB  . ARG   A 1 129 ? 1.25934   10.33082  -25.74299 1.000 15.17825 ? 129 ARG   A CB  1 
ATOM   351  C  CG  . ARG   A 1 129 ? 0.57699   9.14379   -25.09267 1.000 17.78758 ? 129 ARG   A CG  1 
ATOM   352  C  CD  . ARG   A 1 129 ? -0.32807  8.44883   -26.08265 1.000 17.27597 ? 129 ARG   A CD  1 
ATOM   353  N  NE  . ARG   A 1 129 ? -0.77229  7.16502   -25.56004 1.000 15.97190 ? 129 ARG   A NE  1 
ATOM   354  C  CZ  . ARG   A 1 129 ? -0.08795  6.03316   -25.67785 1.000 17.41860 ? 129 ARG   A CZ  1 
ATOM   355  N  NH1 . ARG   A 1 129 ? 1.07637   6.01881   -26.31254 1.000 17.76737 ? 129 ARG   A NH1 1 
ATOM   356  N  NH2 . ARG   A 1 129 ? -0.57077  4.91314   -25.15993 1.000 19.13399 ? 129 ARG   A NH2 1 
ATOM   357  N  N   . ASP   A 1 130 ? 3.50960   13.14066  -25.26064 1.000 23.09270 ? 130 ASP   A N   1 
ATOM   358  C  CA  . ASP   A 1 130 ? 4.35237   14.07647  -26.01803 1.000 28.44483 ? 130 ASP   A CA  1 
ATOM   359  C  C   . ASP   A 1 130 ? 3.68455   14.56882  -27.32292 1.000 21.11983 ? 130 ASP   A C   1 
ATOM   360  O  O   . ASP   A 1 130 ? 4.37497   15.04549  -28.23209 1.000 19.80434 ? 130 ASP   A O   1 
ATOM   361  C  CB  . ASP   A 1 130 ? 5.67995   13.43305  -26.37276 1.000 31.03832 ? 130 ASP   A CB  1 
ATOM   362  C  CG  . ASP   A 1 130 ? 6.80779   13.96956  -25.61865 1.000 53.23497 ? 130 ASP   A CG  1 
ATOM   363  O  OD1 . ASP   A 1 130 ? 6.65214   14.57947  -24.57953 1.000 60.64177 ? 130 ASP   A OD1 1 
ATOM   364  O  OD2 . ASP   A 1 130 ? 7.88541   13.80777  -26.11916 1.000 45.17586 ? 130 ASP   A OD2 1 
ATOM   365  N  N   . LEU   A 1 131 ? 2.34689   14.45653  -27.45754 1.000 21.45323 ? 131 LEU   A N   1 
ATOM   366  C  CA  . LEU   A 1 131 ? 1.73037   14.51942  -28.79139 1.000 16.46475 ? 131 LEU   A CA  1 
ATOM   367  C  C   . LEU   A 1 131 ? 1.62148   15.93544  -29.35042 1.000 18.14559 ? 131 LEU   A C   1 
ATOM   368  O  O   . LEU   A 1 131 ? 1.75307   16.11542  -30.56793 1.000 17.40626 ? 131 LEU   A O   1 
ATOM   369  C  CB  . LEU   A 1 131 ? 0.33691   13.88205  -28.79769 1.000 16.79185 ? 131 LEU   A CB  1 
ATOM   370  C  CG  . LEU   A 1 131 ? 0.24349   12.35253  -28.87188 1.000 16.98631 ? 131 LEU   A CG  1 
ATOM   371  C  CD1 . LEU   A 1 131 ? -1.19755  11.85578  -28.78760 1.000 18.09797 ? 131 LEU   A CD1 1 
ATOM   372  C  CD2 . LEU   A 1 131 ? 0.91557   11.82562  -30.13275 1.000 12.11045 ? 131 LEU   A CD2 1 
ATOM   373  N  N   . LEU   A 1 132 ? 1.30985   16.93638  -28.51278 1.000 16.78139 ? 132 LEU   A N   1 
ATOM   374  C  CA  . LEU   A 1 132 ? 1.31031   18.31767  -28.99740 1.000 21.41348 ? 132 LEU   A CA  1 
ATOM   375  C  C   . LEU   A 1 132 ? 2.67432   18.72112  -29.53754 1.000 19.75563 ? 132 LEU   A C   1 
ATOM   376  O  O   . LEU   A 1 132 ? 2.75651   19.45215  -30.52854 1.000 20.14271 ? 132 LEU   A O   1 
ATOM   377  C  CB  . LEU   A 1 132 ? 0.87822   19.29939  -27.89985 1.000 21.66479 ? 132 LEU   A CB  1 
ATOM   378  C  CG  . LEU   A 1 132 ? -0.53067  19.22702  -27.30307 1.000 24.69081 ? 132 LEU   A CG  1 
ATOM   379  C  CD1 . LEU   A 1 132 ? -0.60809  18.30453  -26.09894 1.000 19.74688 ? 132 LEU   A CD1 1 
ATOM   380  C  CD2 . LEU   A 1 132 ? -1.06418  20.62904  -26.97945 1.000 19.04992 ? 132 LEU   A CD2 1 
ATOM   381  N  N   . LYS   A 1 133 ? 3.75410   18.26232  -28.91285 1.000 23.38198 ? 133 LYS   A N   1 
ATOM   382  C  CA  . LYS   A 1 133 ? 5.06913   18.58111  -29.45329 1.000 25.24960 ? 133 LYS   A CA  1 
ATOM   383  C  C   . LYS   A 1 133 ? 5.36594   17.77652  -30.69956 1.000 22.77552 ? 133 LYS   A C   1 
ATOM   384  O  O   . LYS   A 1 133 ? 5.89425   18.31474  -31.67620 1.000 20.39410 ? 133 LYS   A O   1 
ATOM   385  C  CB  . LYS   A 1 133 ? 6.15727   18.35690  -28.41993 1.000 29.24232 ? 133 LYS   A CB  1 
ATOM   386  C  CG  . LYS   A 1 133 ? 5.96926   19.24325  -27.25404 1.000 38.21201 ? 133 LYS   A CG  1 
ATOM   387  C  CD  . LYS   A 1 133 ? 5.19072   18.56475  -26.13011 1.000 45.66816 ? 133 LYS   A CD  1 
ATOM   388  C  CE  . LYS   A 1 133 ? 5.95924   17.45507  -25.46046 1.000 42.99890 ? 133 LYS   A CE  1 
ATOM   389  N  NZ  . LYS   A 1 133 ? 5.09873   16.78421  -24.34873 1.000 48.17930 ? 133 LYS   A NZ  1 
ATOM   390  N  N   . THR   A 1 134 ? 5.05983   16.48060  -30.67869 1.000 20.96935 ? 134 THR   A N   1 
ATOM   391  C  CA  . THR   A 1 134 ? 5.37914   15.63472  -31.82263 1.000 19.45745 ? 134 THR   A CA  1 
ATOM   392  C  C   . THR   A 1 134 ? 4.69552   16.12821  -33.09378 1.000 18.20273 ? 134 THR   A C   1 
ATOM   393  O  O   . THR   A 1 134 ? 5.28865   16.09644  -34.17859 1.000 22.03346 ? 134 THR   A O   1 
ATOM   394  C  CB  . THR   A 1 134 ? 4.98326   14.19049  -31.52210 1.000 20.45950 ? 134 THR   A CB  1 
ATOM   395  O  OG1 . THR   A 1 134 ? 5.76966   13.70544  -30.42628 1.000 21.04992 ? 134 THR   A OG1 1 
ATOM   396  C  CG2 . THR   A 1 134 ? 5.20932   13.30399  -32.73802 1.000 17.66150 ? 134 THR   A CG2 1 
ATOM   397  N  N   . PHE   A 1 135 ? 3.45463   16.60026  -32.98143 1.000 16.70559 ? 135 PHE   A N   1 
ATOM   398  C  CA  . PHE   A 1 135 ? 2.67377   17.01225  -34.14047 1.000 19.76455 ? 135 PHE   A CA  1 
ATOM   399  C  C   . PHE   A 1 135 ? 2.39998   18.51025  -34.16760 1.000 16.82782 ? 135 PHE   A C   1 
ATOM   400  O  O   . PHE   A 1 135 ? 1.55623   18.96094  -34.94962 1.000 16.94816 ? 135 PHE   A O   1 
ATOM   401  C  CB  . PHE   A 1 135 ? 1.36891   16.21503  -34.19152 1.000 15.26142 ? 135 PHE   A CB  1 
ATOM   402  C  CG  . PHE   A 1 135 ? 1.58113   14.75849  -34.47804 1.000 14.37414 ? 135 PHE   A CG  1 
ATOM   403  C  CD1 . PHE   A 1 135 ? 1.90805   14.34021  -35.75599 1.000 18.40798 ? 135 PHE   A CD1 1 
ATOM   404  C  CD2 . PHE   A 1 135 ? 1.49363   13.81273  -33.47071 1.000 12.84140 ? 135 PHE   A CD2 1 
ATOM   405  C  CE1 . PHE   A 1 135 ? 2.12495   13.00746  -36.03128 1.000 14.63360 ? 135 PHE   A CE1 1 
ATOM   406  C  CE2 . PHE   A 1 135 ? 1.71089   12.47390  -33.74119 1.000 15.62832 ? 135 PHE   A CE2 1 
ATOM   407  C  CZ  . PHE   A 1 135 ? 2.02657   12.07251  -35.02412 1.000 13.77893 ? 135 PHE   A CZ  1 
ATOM   408  N  N   . LYS   A 1 136 ? 3.10307   19.28693  -33.34265 1.000 22.44659 ? 136 LYS   A N   1 
ATOM   409  C  CA  . LYS   A 1 136 ? 3.03121   20.74792  -33.36066 1.000 18.52216 ? 136 LYS   A CA  1 
ATOM   410  C  C   . LYS   A 1 136 ? 1.58670   21.22911  -33.23432 1.000 19.11973 ? 136 LYS   A C   1 
ATOM   411  O  O   . LYS   A 1 136 ? 1.12079   22.09433  -33.97821 1.000 18.41732 ? 136 LYS   A O   1 
ATOM   412  C  CB  . LYS   A 1 136 ? 3.69207   21.30830  -34.62002 1.000 17.91137 ? 136 LYS   A CB  1 
ATOM   413  C  CG  . LYS   A 1 136 ? 5.15575   20.91485  -34.77977 1.000 26.24173 ? 136 LYS   A CG  1 
ATOM   414  C  CD  . LYS   A 1 136 ? 5.69911   21.34634  -36.13484 1.000 27.95985 ? 136 LYS   A CD  1 
ATOM   415  C  CE  . LYS   A 1 136 ? 6.98906   20.61458  -36.48557 1.000 41.23290 ? 136 LYS   A CE  1 
ATOM   416  N  NZ  . LYS   A 1 136 ? 8.15057   21.08898  -35.68199 1.000 45.45423 ? 136 LYS   A NZ  1 
ATOM   417  N  N   . ILE   A 1 137 ? 0.86713   20.64674  -32.27670 1.000 16.65685 ? 137 ILE   A N   1 
ATOM   418  C  CA  . ILE   A 1 137 ? -0.52145  20.98970  -32.01373 1.000 20.28937 ? 137 ILE   A CA  1 
ATOM   419  C  C   . ILE   A 1 137 ? -0.53441  22.17173  -31.03928 1.000 19.83611 ? 137 ILE   A C   1 
ATOM   420  O  O   . ILE   A 1 137 ? -0.08311  22.00503  -29.89433 1.000 22.95192 ? 137 ILE   A O   1 
ATOM   421  C  CB  . ILE   A 1 137 ? -1.30272  19.80176  -31.44144 1.000 16.38878 ? 137 ILE   A CB  1 
ATOM   422  C  CG1 . ILE   A 1 137 ? -1.11939  18.56704  -32.32084 1.000 17.84117 ? 137 ILE   A CG1 1 
ATOM   423  C  CG2 . ILE   A 1 137 ? -2.78091  20.14363  -31.30697 1.000 14.72929 ? 137 ILE   A CG2 1 
ATOM   424  C  CD1 . ILE   A 1 137 ? -1.78052  17.32245  -31.76167 1.000 16.51853 ? 137 ILE   A CD1 1 
ATOM   425  N  N   . PRO   A 1 138 ? -1.01622  23.34200  -31.44060 1.000 20.95689 ? 138 PRO   A N   1 
ATOM   426  C  CA  . PRO   A 1 138 ? -1.17558  24.43496  -30.47388 1.000 18.17194 ? 138 PRO   A CA  1 
ATOM   427  C  C   . PRO   A 1 138 ? -2.14752  24.03142  -29.37613 1.000 22.10664 ? 138 PRO   A C   1 
ATOM   428  O  O   . PRO   A 1 138 ? -3.20207  23.44922  -29.64168 1.000 21.25249 ? 138 PRO   A O   1 
ATOM   429  C  CB  . PRO   A 1 138 ? -1.72412  25.58775  -31.32345 1.000 22.11294 ? 138 PRO   A CB  1 
ATOM   430  C  CG  . PRO   A 1 138 ? -1.31517  25.25511  -32.72530 1.000 21.97993 ? 138 PRO   A CG  1 
ATOM   431  C  CD  . PRO   A 1 138 ? -1.36736  23.75958  -32.80836 1.000 23.66226 ? 138 PRO   A CD  1 
ATOM   432  N  N   . VAL   A 1 139 ? -1.78022  24.34321  -28.13002 1.000 18.84948 ? 139 VAL   A N   1 
ATOM   433  C  CA  . VAL   A 1 139 ? -2.57467  23.89159  -26.99000 1.000 21.47811 ? 139 VAL   A CA  1 
ATOM   434  C  C   . VAL   A 1 139 ? -3.96805  24.50572  -27.03036 1.000 19.38920 ? 139 VAL   A C   1 
ATOM   435  O  O   . VAL   A 1 139 ? -4.95778  23.85656  -26.67090 1.000 19.77121 ? 139 VAL   A O   1 
ATOM   436  C  CB  . VAL   A 1 139 ? -1.84388  24.19901  -25.66725 1.000 27.07161 ? 139 VAL   A CB  1 
ATOM   437  C  CG1 . VAL   A 1 139 ? -1.65062  25.69856  -25.47605 1.000 21.15082 ? 139 VAL   A CG1 1 
ATOM   438  C  CG2 . VAL   A 1 139 ? -2.59711  23.59486  -24.48884 1.000 24.19924 ? 139 VAL   A CG2 1 
ATOM   439  N  N   . ASP   A 1 140 ? -4.07370  25.75428  -27.49216 1.000 16.46772 ? 140 ASP   A N   1 
ATOM   440  C  CA  . ASP   A 1 140 ? -5.38204  26.39210  -27.58775 1.000 19.07467 ? 140 ASP   A CA  1 
ATOM   441  C  C   . ASP   A 1 140 ? -6.22322  25.76070  -28.69012 1.000 18.67240 ? 140 ASP   A C   1 
ATOM   442  O  O   . ASP   A 1 140 ? -7.44656  25.64282  -28.55360 1.000 18.04089 ? 140 ASP   A O   1 
ATOM   443  C  CB  . ASP   A 1 140 ? -5.22152  27.89446  -27.82163 1.000 21.34720 ? 140 ASP   A CB  1 
ATOM   444  C  CG  . ASP   A 1 140 ? -4.26344  28.21220  -28.95455 1.000 27.47795 ? 140 ASP   A CG  1 
ATOM   445  O  OD1 . ASP   A 1 140 ? -3.09028  27.78538  -28.89016 1.000 35.87270 ? 140 ASP   A OD1 1 
ATOM   446  O  OD2 . ASP   A 1 140 ? -4.68780  28.88877  -29.91486 1.000 39.61358 ? 140 ASP   A OD2 1 
ATOM   447  N  N   . THR   A 1 141 ? -5.58789  25.35107  -29.79036 1.000 15.89039 ? 141 THR   A N   1 
ATOM   448  C  CA  . THR   A 1 141 ? -6.31126  24.63501  -30.83621 1.000 18.51192 ? 141 THR   A CA  1 
ATOM   449  C  C   . THR   A 1 141 ? -6.83811  23.30539  -30.31354 1.000 18.05151 ? 141 THR   A C   1 
ATOM   450  O  O   . THR   A 1 141 ? -7.99375  22.94021  -30.55967 1.000 14.41039 ? 141 THR   A O   1 
ATOM   451  C  CB  . THR   A 1 141 ? -5.40617  24.41259  -32.04867 1.000 19.22490 ? 141 THR   A CB  1 
ATOM   452  O  OG1 . THR   A 1 141 ? -4.74687  25.63893  -32.38669 1.000 24.11836 ? 141 THR   A OG1 1 
ATOM   453  C  CG2 . THR   A 1 141 ? -6.22298  23.93571  -33.24312 1.000 20.22936 ? 141 THR   A CG2 1 
ATOM   454  N  N   . LEU   A 1 142 ? -5.99717  22.57037  -29.58104 1.000 16.03444 ? 142 LEU   A N   1 
ATOM   455  C  CA  . LEU   A 1 142 ? -6.41686  21.29672  -29.00621 1.000 16.13435 ? 142 LEU   A CA  1 
ATOM   456  C  C   . LEU   A 1 142 ? -7.61745  21.48129  -28.08743 1.000 16.84254 ? 142 LEU   A C   1 
ATOM   457  O  O   . LEU   A 1 142 ? -8.64026  20.80496  -28.24154 1.000 16.86707 ? 142 LEU   A O   1 
ATOM   458  C  CB  . LEU   A 1 142 ? -5.24969  20.65588  -28.25268 1.000 13.78604 ? 142 LEU   A CB  1 
ATOM   459  C  CG  . LEU   A 1 142 ? -5.51678  19.29780  -27.60003 1.000 14.97867 ? 142 LEU   A CG  1 
ATOM   460  C  CD1 . LEU   A 1 142 ? -6.07752  18.31574  -28.61641 1.000 13.50398 ? 142 LEU   A CD1 1 
ATOM   461  C  CD2 . LEU   A 1 142 ? -4.25071  18.74890  -26.96200 1.000 14.92938 ? 142 LEU   A CD2 1 
ATOM   462  N  N   . ILE   A 1 143 ? -7.51591  22.41138  -27.13445 1.000 16.99605 ? 143 ILE   A N   1 
ATOM   463  C  CA  . ILE   A 1 143 ? -8.61200  22.64386  -26.19709 1.000 14.52317 ? 143 ILE   A CA  1 
ATOM   464  C  C   . ILE   A 1 143 ? -9.87918  23.04501  -26.94155 1.000 15.87138 ? 143 ILE   A C   1 
ATOM   465  O  O   . ILE   A 1 143 ? -10.97627 22.56249  -26.63404 1.000 15.84613 ? 143 ILE   A O   1 
ATOM   466  C  CB  . ILE   A 1 143 ? -8.20951  23.70517  -25.15571 1.000 15.48839 ? 143 ILE   A CB  1 
ATOM   467  C  CG1 . ILE   A 1 143 ? -7.00696  23.22969  -24.33781 1.000 18.11914 ? 143 ILE   A CG1 1 
ATOM   468  C  CG2 . ILE   A 1 143 ? -9.38287  24.03181  -24.24349 1.000 17.57496 ? 143 ILE   A CG2 1 
ATOM   469  C  CD1 . ILE   A 1 143 ? -7.20939  21.88814  -23.67286 1.000 24.07202 ? 143 ILE   A CD1 1 
ATOM   470  N  N   . THR   A 1 144 ? -9.74889  23.92063  -27.94075 1.000 13.44145 ? 144 THR   A N   1 
ATOM   471  C  CA  . THR   A 1 144 ? -10.92631 24.41051  -28.65094 1.000 15.52559 ? 144 THR   A CA  1 
ATOM   472  C  C   . THR   A 1 144 ? -11.62176 23.28647  -29.41013 1.000 16.46540 ? 144 THR   A C   1 
ATOM   473  O  O   . THR   A 1 144 ? -12.84757 23.14234  -29.33599 1.000 12.97358 ? 144 THR   A O   1 
ATOM   474  C  CB  . THR   A 1 144 ? -10.54174 25.54578  -29.60008 1.000 17.96479 ? 144 THR   A CB  1 
ATOM   475  O  OG1 . THR   A 1 144 ? -9.93903  26.61101  -28.85359 1.000 15.03367 ? 144 THR   A OG1 1 
ATOM   476  C  CG2 . THR   A 1 144 ? -11.77557 26.07595  -30.31507 1.000 15.28256 ? 144 THR   A CG2 1 
ATOM   477  N  N   . TYR   A 1 145 ? -10.85791 22.47598  -30.14861 1.000 13.20508 ? 145 TYR   A N   1 
ATOM   478  C  CA  . TYR   A 1 145 ? -11.46950 21.35323  -30.85300 1.000 13.54405 ? 145 TYR   A CA  1 
ATOM   479  C  C   . TYR   A 1 145 ? -12.11841 20.38536  -29.87500 1.000 13.22274 ? 145 TYR   A C   1 
ATOM   480  O  O   . TYR   A 1 145 ? -13.25591 19.94624  -30.08056 1.000 14.64874 ? 145 TYR   A O   1 
ATOM   481  C  CB  . TYR   A 1 145 ? -10.44499 20.60961  -31.70904 1.000 16.31229 ? 145 TYR   A CB  1 
ATOM   482  C  CG  . TYR   A 1 145 ? -11.04518 19.35558  -32.30704 1.000 20.14017 ? 145 TYR   A CG  1 
ATOM   483  C  CD1 . TYR   A 1 145 ? -11.81374 19.42106  -33.45993 1.000 16.77064 ? 145 TYR   A CD1 1 
ATOM   484  C  CD2 . TYR   A 1 145 ? -10.87893 18.11414  -31.69842 1.000 13.45638 ? 145 TYR   A CD2 1 
ATOM   485  C  CE1 . TYR   A 1 145 ? -12.38479 18.28886  -34.00298 1.000 15.07799 ? 145 TYR   A CE1 1 
ATOM   486  C  CE2 . TYR   A 1 145 ? -11.44881 16.97523  -32.23465 1.000 14.14128 ? 145 TYR   A CE2 1 
ATOM   487  C  CZ  . TYR   A 1 145 ? -12.19914 17.06867  -33.38673 1.000 13.63385 ? 145 TYR   A CZ  1 
ATOM   488  O  OH  . TYR   A 1 145 ? -12.76625 15.93741  -33.92552 1.000 10.38955 ? 145 TYR   A OH  1 
ATOM   489  N  N   . LEU   A 1 146 ? -11.39417 20.02280  -28.81367 1.000 12.78788 ? 146 LEU   A N   1 
ATOM   490  C  CA  . LEU   A 1 146 ? -11.92082 19.06821  -27.84426 1.000 14.71922 ? 146 LEU   A CA  1 
ATOM   491  C  C   . LEU   A 1 146 ? -13.23582 19.55600  -27.25311 1.000 14.75761 ? 146 LEU   A C   1 
ATOM   492  O  O   . LEU   A 1 146 ? -14.19609 18.78756  -27.12975 1.000 14.57913 ? 146 LEU   A O   1 
ATOM   493  C  CB  . LEU   A 1 146 ? -10.89422 18.81702  -26.73998 1.000 15.03790 ? 146 LEU   A CB  1 
ATOM   494  C  CG  . LEU   A 1 146 ? -9.62690  18.07406  -27.16404 1.000 14.91490 ? 146 LEU   A CG  1 
ATOM   495  C  CD1 . LEU   A 1 146 ? -8.64775  17.96476  -26.00462 1.000 12.16032 ? 146 LEU   A CD1 1 
ATOM   496  C  CD2 . LEU   A 1 146 ? -9.97556  16.70565  -27.71640 1.000 11.94655 ? 146 LEU   A CD2 1 
ATOM   497  N  N   . MET   A 1 147 ? -13.30221 20.83892  -26.89022 1.000 14.23794 ? 147 MET   A N   1 
ATOM   498  C  CA  . MET   A 1 147 ? -14.53457 21.37225  -26.32043 1.000 21.95712 ? 147 MET   A CA  1 
ATOM   499  C  C   . MET   A 1 147 ? -15.66424 21.35717  -27.34324 1.000 17.01332 ? 147 MET   A C   1 
ATOM   500  O  O   . MET   A 1 147 ? -16.80503 21.01579  -27.01133 1.000 19.16352 ? 147 MET   A O   1 
ATOM   501  C  CB  . MET   A 1 147 ? -14.29899 22.78480  -25.78366 1.000 15.78875 ? 147 MET   A CB  1 
ATOM   502  C  CG  . MET   A 1 147 ? -13.38980 22.82671  -24.55909 1.000 20.20283 ? 147 MET   A CG  1 
ATOM   503  S  SD  . MET   A 1 147 ? -13.37381 24.41830  -23.71094 1.000 39.08612 ? 147 MET   A SD  1 
ATOM   504  C  CE  . MET   A 1 147 ? -14.88311 24.30786  -22.75463 1.000 32.99298 ? 147 MET   A CE  1 
ATOM   505  N  N   . THR   A 1 148 ? -15.36549 21.70944  -28.59673 1.000 14.06001 ? 148 THR   A N   1 
ATOM   506  C  CA  . THR   A 1 148 ? -16.38501 21.63622  -29.63936 1.000 14.53506 ? 148 THR   A CA  1 
ATOM   507  C  C   . THR   A 1 148 ? -16.80639 20.19429  -29.89158 1.000 13.81191 ? 148 THR   A C   1 
ATOM   508  O  O   . THR   A 1 148 ? -18.00083 19.90236  -30.02639 1.000 13.93453 ? 148 THR   A O   1 
ATOM   509  C  CB  . THR   A 1 148 ? -15.87491 22.27249  -30.93250 1.000 19.62487 ? 148 THR   A CB  1 
ATOM   510  O  OG1 . THR   A 1 148 ? -15.28786 23.54733  -30.64393 1.000 27.30188 ? 148 THR   A OG1 1 
ATOM   511  C  CG2 . THR   A 1 148 ? -17.02218 22.46001  -31.91672 1.000 19.36021 ? 148 THR   A CG2 1 
ATOM   512  N  N   . LEU   A 1 149 ? -15.83657 19.27915  -29.96177 1.000 14.01152 ? 149 LEU   A N   1 
ATOM   513  C  CA  . LEU   A 1 149 ? -16.15649 17.86388  -30.11834 1.000 12.49672 ? 149 LEU   A CA  1 
ATOM   514  C  C   . LEU   A 1 149 ? -17.01672 17.36789  -28.96296 1.000 11.40377 ? 149 LEU   A C   1 
ATOM   515  O  O   . LEU   A 1 149 ? -18.02318 16.68021  -29.17168 1.000 11.86241 ? 149 LEU   A O   1 
ATOM   516  C  CB  . LEU   A 1 149 ? -14.86941 17.04433  -30.21909 1.000 11.84208 ? 149 LEU   A CB  1 
ATOM   517  C  CG  . LEU   A 1 149 ? -15.06375 15.52811  -30.31056 1.000 12.02476 ? 149 LEU   A CG  1 
ATOM   518  C  CD1 . LEU   A 1 149 ? -15.66893 15.14124  -31.65183 1.000 9.07300  ? 149 LEU   A CD1 1 
ATOM   519  C  CD2 . LEU   A 1 149 ? -13.75714 14.78708  -30.06834 1.000 11.69632 ? 149 LEU   A CD2 1 
ATOM   520  N  N   . GLU   A 1 150 ? -16.63561 17.71640  -27.73128 1.000 11.24102 ? 150 GLU   A N   1 
ATOM   521  C  CA  . GLU   A 1 150 ? -17.39994 17.28096  -26.56701 1.000 16.39150 ? 150 GLU   A CA  1 
ATOM   522  C  C   . GLU   A 1 150 ? -18.80526 17.86857  -26.57633 1.000 14.57941 ? 150 GLU   A C   1 
ATOM   523  O  O   . GLU   A 1 150 ? -19.76572 17.20359  -26.16899 1.000 13.17777 ? 150 GLU   A O   1 
ATOM   524  C  CB  . GLU   A 1 150 ? -16.66304 17.66444  -25.28444 1.000 15.58250 ? 150 GLU   A CB  1 
ATOM   525  C  CG  . GLU   A 1 150 ? -17.33304 17.16913  -24.02002 1.000 16.76751 ? 150 GLU   A CG  1 
ATOM   526  C  CD  . GLU   A 1 150 ? -16.34164 16.88044  -22.91677 1.000 12.92278 ? 150 GLU   A CD  1 
ATOM   527  O  OE1 . GLU   A 1 150 ? -15.24286 17.47488  -22.92422 1.000 11.85507 ? 150 GLU   A OE1 1 
ATOM   528  O  OE2 . GLU   A 1 150 ? -16.65934 16.04267  -22.05102 1.000 13.60241 ? 150 GLU   A OE2 1 
ATOM   529  N  N   . ASP   A 1 151 ? -18.94517 19.11453  -27.04204 1.000 14.30484 ? 151 ASP   A N   1 
ATOM   530  C  CA  . ASP   A 1 151 ? -20.26734 19.72350  -27.15459 1.000 14.67094 ? 151 ASP   A CA  1 
ATOM   531  C  C   . ASP   A 1 151 ? -21.19412 18.90040  -28.03333 1.000 17.18322 ? 151 ASP   A C   1 
ATOM   532  O  O   . ASP   A 1 151 ? -22.40919 18.87795  -27.80573 1.000 15.54190 ? 151 ASP   A O   1 
ATOM   533  C  CB  . ASP   A 1 151 ? -20.16326 21.13850  -27.72517 1.000 20.19457 ? 151 ASP   A CB  1 
ATOM   534  C  CG  . ASP   A 1 151 ? -19.49948 22.10563  -26.77619 1.000 21.83557 ? 151 ASP   A CG  1 
ATOM   535  O  OD1 . ASP   A 1 151 ? -19.39147 21.78456  -25.57454 1.000 22.30987 ? 151 ASP   A OD1 1 
ATOM   536  O  OD2 . ASP   A 1 151 ? -19.09009 23.19254  -27.23666 1.000 30.93908 ? 151 ASP   A OD2 1 
ATOM   537  N  N   . HIS   A 1 152 ? -20.64982 18.22676  -29.03967 1.000 15.05881 ? 152 HIS   A N   1 
ATOM   538  C  CA  . HIS   A 1 152 ? -21.47803 17.54428  -30.01894 1.000 15.86688 ? 152 HIS   A CA  1 
ATOM   539  C  C   . HIS   A 1 152 ? -21.80637 16.11392  -29.62751 1.000 15.73543 ? 152 HIS   A C   1 
ATOM   540  O  O   . HIS   A 1 152 ? -22.48273 15.42058  -30.38975 1.000 14.73424 ? 152 HIS   A O   1 
ATOM   541  C  CB  . HIS   A 1 152 ? -20.80848 17.59545  -31.39076 1.000 14.51734 ? 152 HIS   A CB  1 
ATOM   542  C  CG  . HIS   A 1 152 ? -20.89000 18.94443  -32.03179 1.000 15.35402 ? 152 HIS   A CG  1 
ATOM   543  N  ND1 . HIS   A 1 152 ? -20.08494 19.99717  -31.65231 1.000 16.41103 ? 152 HIS   A ND1 1 
ATOM   544  C  CD2 . HIS   A 1 152 ? -21.70457 19.42347  -33.00133 1.000 11.69475 ? 152 HIS   A CD2 1 
ATOM   545  C  CE1 . HIS   A 1 152 ? -20.38855 21.06202  -32.37265 1.000 16.54285 ? 152 HIS   A CE1 1 
ATOM   546  N  NE2 . HIS   A 1 152 ? -21.36756 20.74041  -33.19922 1.000 12.73338 ? 152 HIS   A NE2 1 
ATOM   547  N  N   . TYR   A 1 153 ? -21.34928 15.65789  -28.46861 1.000 14.66441 ? 153 TYR   A N   1 
ATOM   548  C  CA  . TYR   A 1 153 ? -21.99625 14.53270  -27.81959 1.000 13.96654 ? 153 TYR   A CA  1 
ATOM   549  C  C   . TYR   A 1 153 ? -23.23489 15.03486  -27.09017 1.000 16.63677 ? 153 TYR   A C   1 
ATOM   550  O  O   . TYR   A 1 153 ? -23.25639 16.14741  -26.55668 1.000 17.30134 ? 153 TYR   A O   1 
ATOM   551  C  CB  . TYR   A 1 153 ? -21.04295 13.84051  -26.84742 1.000 13.10793 ? 153 TYR   A CB  1 
ATOM   552  C  CG  . TYR   A 1 153 ? -20.03584 12.94272  -27.52736 1.000 13.34732 ? 153 TYR   A CG  1 
ATOM   553  C  CD1 . TYR   A 1 153 ? -18.83745 13.45120  -28.01254 1.000 12.81480 ? 153 TYR   A CD1 1 
ATOM   554  C  CD2 . TYR   A 1 153 ? -20.28520 11.58735  -27.68422 1.000 10.42035 ? 153 TYR   A CD2 1 
ATOM   555  C  CE1 . TYR   A 1 153 ? -17.91546 12.63316  -28.63551 1.000 8.94346  ? 153 TYR   A CE1 1 
ATOM   556  C  CE2 . TYR   A 1 153 ? -19.37006 10.76193  -28.30133 1.000 11.14363 ? 153 TYR   A CE2 1 
ATOM   557  C  CZ  . TYR   A 1 153 ? -18.18835 11.28973  -28.77925 1.000 9.30825  ? 153 TYR   A CZ  1 
ATOM   558  O  OH  . TYR   A 1 153 ? -17.27257 10.47167  -29.39874 1.000 11.21435 ? 153 TYR   A OH  1 
ATOM   559  N  N   . HIS   A 1 154 ? -24.27977 14.21375  -27.08676 1.000 15.13059 ? 154 HIS   A N   1 
ATOM   560  C  CA  . HIS   A 1 154 ? -25.56955 14.63170  -26.54778 1.000 18.41421 ? 154 HIS   A CA  1 
ATOM   561  C  C   . HIS   A 1 154 ? -25.56043 14.47474  -25.03215 1.000 22.09585 ? 154 HIS   A C   1 
ATOM   562  O  O   . HIS   A 1 154 ? -25.49588 13.35430  -24.51507 1.000 14.89857 ? 154 HIS   A O   1 
ATOM   563  C  CB  . HIS   A 1 154 ? -26.70200 13.82511  -27.17484 1.000 13.81005 ? 154 HIS   A CB  1 
ATOM   564  C  CG  . HIS   A 1 154 ? -26.86802 14.05172  -28.64593 1.000 20.25912 ? 154 HIS   A CG  1 
ATOM   565  N  ND1 . HIS   A 1 154 ? -28.06114 13.83267  -29.30093 1.000 18.42390 ? 154 HIS   A ND1 1 
ATOM   566  C  CD2 . HIS   A 1 154 ? -25.99157 14.46798  -29.59077 1.000 15.33776 ? 154 HIS   A CD2 1 
ATOM   567  C  CE1 . HIS   A 1 154 ? -27.91435 14.11067  -30.58404 1.000 17.84851 ? 154 HIS   A CE1 1 
ATOM   568  N  NE2 . HIS   A 1 154 ? -26.66754 14.49722  -30.78635 1.000 19.68234 ? 154 HIS   A NE2 1 
ATOM   569  N  N   . ALA   A 1 155 ? -25.63626 15.60005  -24.31684 1.000 18.97139 ? 155 ALA   A N   1 
ATOM   570  C  CA  . ALA   A 1 155 ? -25.74365 15.56706  -22.86274 1.000 22.03958 ? 155 ALA   A CA  1 
ATOM   571  C  C   . ALA   A 1 155 ? -27.03512 14.91568  -22.38854 1.000 21.46592 ? 155 ALA   A C   1 
ATOM   572  O  O   . ALA   A 1 155 ? -27.16674 14.63552  -21.19173 1.000 25.90666 ? 155 ALA   A O   1 
ATOM   573  C  CB  . ALA   A 1 155 ? -25.64453 16.98564  -22.29645 1.000 26.27017 ? 155 ALA   A CB  1 
ATOM   574  N  N   . ASP   A 1 156 ? -27.97725 14.66503  -23.29531 1.000 20.82487 ? 156 ASP   A N   1 
ATOM   575  C  CA  . ASP   A 1 156 ? -29.28081 14.10059  -22.98144 1.000 25.17461 ? 156 ASP   A CA  1 
ATOM   576  C  C   . ASP   A 1 156 ? -29.35589 12.59978  -23.22686 1.000 25.85248 ? 156 ASP   A C   1 
ATOM   577  O  O   . ASP   A 1 156 ? -30.42813 12.01141  -23.05826 1.000 22.74090 ? 156 ASP   A O   1 
ATOM   578  C  CB  . ASP   A 1 156 ? -30.35698 14.80353  -23.81326 1.000 30.87280 ? 156 ASP   A CB  1 
ATOM   579  C  CG  . ASP   A 1 156 ? -30.12072 14.65502  -25.30535 1.000 34.68945 ? 156 ASP   A CG  1 
ATOM   580  O  OD1 . ASP   A 1 156 ? -29.26723 15.38749  -25.84982 1.000 34.29038 ? 156 ASP   A OD1 1 
ATOM   581  O  OD2 . ASP   A 1 156 ? -30.77936 13.79861  -25.93399 1.000 42.66375 ? 156 ASP   A OD2 1 
ATOM   582  N  N   . VAL   A 1 157 ? -28.25705 11.97118  -23.63406 1.000 16.59026 ? 157 VAL   A N   1 
ATOM   583  C  CA  . VAL   A 1 157 ? -28.21928 10.54608  -23.94572 1.000 16.58288 ? 157 VAL   A CA  1 
ATOM   584  C  C   . VAL   A 1 157 ? -27.51610 9.83105   -22.79886 1.000 18.54229 ? 157 VAL   A C   1 
ATOM   585  O  O   . VAL   A 1 157 ? -26.44950 10.27203  -22.35267 1.000 13.39035 ? 157 VAL   A O   1 
ATOM   586  C  CB  . VAL   A 1 157 ? -27.51583 10.29134  -25.29074 1.000 21.29247 ? 157 VAL   A CB  1 
ATOM   587  C  CG1 . VAL   A 1 157 ? -27.23520 8.81815   -25.47641 1.000 14.16188 ? 157 VAL   A CG1 1 
ATOM   588  C  CG2 . VAL   A 1 157 ? -28.37412 10.80794  -26.43466 1.000 17.77354 ? 157 VAL   A CG2 1 
ATOM   589  N  N   . ALA   A 1 158 ? -28.11302 8.73209   -22.31287 1.000 15.24389 ? 158 ALA   A N   1 
ATOM   590  C  CA  . ALA   A 1 158 ? -27.63363 8.14057   -21.06106 1.000 17.23665 ? 158 ALA   A CA  1 
ATOM   591  C  C   . ALA   A 1 158 ? -26.26831 7.50372   -21.21093 1.000 11.99079 ? 158 ALA   A C   1 
ATOM   592  O  O   . ALA   A 1 158 ? -25.44479 7.58202   -20.29442 1.000 13.59690 ? 158 ALA   A O   1 
ATOM   593  C  CB  . ALA   A 1 158 ? -28.58376 7.07345   -20.53105 1.000 14.11066 ? 158 ALA   A CB  1 
ATOM   594  N  N   . TYR   A 1 159 ? -26.04083 6.78522   -22.30440 1.000 15.93420 ? 159 TYR   A N   1 
ATOM   595  C  CA  . TYR   A 1 159 ? -24.80081 6.04436   -22.46646 1.000 11.27563 ? 159 TYR   A CA  1 
ATOM   596  C  C   . TYR   A 1 159 ? -23.89372 6.67031   -23.51681 1.000 13.13800 ? 159 TYR   A C   1 
ATOM   597  O  O   . TYR   A 1 159 ? -22.74249 6.99732   -23.21868 1.000 11.03806 ? 159 TYR   A O   1 
ATOM   598  C  CB  . TYR   A 1 159 ? -25.09368 4.57669   -22.81230 1.000 12.83956 ? 159 TYR   A CB  1 
ATOM   599  C  CG  . TYR   A 1 159 ? -23.84532 3.73683   -22.96234 1.000 14.69281 ? 159 TYR   A CG  1 
ATOM   600  C  CD1 . TYR   A 1 159 ? -23.17941 3.65641   -24.18070 1.000 11.43240 ? 159 TYR   A CD1 1 
ATOM   601  C  CD2 . TYR   A 1 159 ? -23.32521 3.03477   -21.88338 1.000 13.50731 ? 159 TYR   A CD2 1 
ATOM   602  C  CE1 . TYR   A 1 159 ? -22.03440 2.89969   -24.32040 1.000 11.83337 ? 159 TYR   A CE1 1 
ATOM   603  C  CE2 . TYR   A 1 159 ? -22.18073 2.27221   -22.01378 1.000 13.23981 ? 159 TYR   A CE2 1 
ATOM   604  C  CZ  . TYR   A 1 159 ? -21.53942 2.20913   -23.23461 1.000 14.23025 ? 159 TYR   A CZ  1 
ATOM   605  O  OH  . TYR   A 1 159 ? -20.39918 1.45274   -23.37304 1.000 12.18315 ? 159 TYR   A OH  1 
ATOM   606  N  N   . HIS   A 1 160 ? -24.37578 6.83660   -24.74851 1.000 11.32889 ? 160 HIS   A N   1 
ATOM   607  C  CA  . HIS   A 1 160 ? -23.52420 7.27627   -25.85321 1.000 10.73799 ? 160 HIS   A CA  1 
ATOM   608  C  C   . HIS   A 1 160 ? -23.32721 8.79380   -25.81186 1.000 13.83620 ? 160 HIS   A C   1 
ATOM   609  O  O   . HIS   A 1 160 ? -23.76253 9.54439   -26.68569 1.000 10.73014 ? 160 HIS   A O   1 
ATOM   610  C  CB  . HIS   A 1 160 ? -24.10644 6.81514   -27.18248 1.000 7.87137  ? 160 HIS   A CB  1 
ATOM   611  C  CG  . HIS   A 1 160 ? -23.99297 5.33877   -27.40562 1.000 13.48606 ? 160 HIS   A CG  1 
ATOM   612  N  ND1 . HIS   A 1 160 ? -25.05869 4.47815   -27.25335 1.000 9.76746  ? 160 HIS   A ND1 1 
ATOM   613  C  CD2 . HIS   A 1 160 ? -22.93423 4.56835   -27.75232 1.000 11.41290 ? 160 HIS   A CD2 1 
ATOM   614  C  CE1 . HIS   A 1 160 ? -24.66385 3.24265   -27.50536 1.000 11.26039 ? 160 HIS   A CE1 1 
ATOM   615  N  NE2 . HIS   A 1 160 ? -23.37890 3.26978   -27.81003 1.000 10.82472 ? 160 HIS   A NE2 1 
ATOM   616  N  N   . ASN   A 1 161 ? -22.63554 9.22928   -24.76460 1.000 11.66259 ? 161 ASN   A N   1 
ATOM   617  C  CA  . ASN   A 1 161 ? -22.38669 10.63242  -24.47362 1.000 13.01782 ? 161 ASN   A CA  1 
ATOM   618  C  C   . ASN   A 1 161 ? -20.88132 10.86692  -24.34455 1.000 12.29862 ? 161 ASN   A C   1 
ATOM   619  O  O   . ASN   A 1 161 ? -20.06272 10.00510  -24.68045 1.000 10.83328 ? 161 ASN   A O   1 
ATOM   620  C  CB  . ASN   A 1 161 ? -23.13964 11.04970  -23.20641 1.000 12.59921 ? 161 ASN   A CB  1 
ATOM   621  C  CG  . ASN   A 1 161 ? -22.84439 10.14180  -22.02375 1.000 12.54995 ? 161 ASN   A CG  1 
ATOM   622  O  OD1 . ASN   A 1 161 ? -21.68639 9.90614   -21.67964 1.000 11.35368 ? 161 ASN   A OD1 1 
ATOM   623  N  ND2 . ASN   A 1 161 ? -23.89514 9.61946   -21.40257 1.000 11.08731 ? 161 ASN   A ND2 1 
ATOM   624  N  N   . ASN   A 1 162 ? -20.52178 12.04547  -23.83181 1.000 10.76192 ? 162 ASN   A N   1 
ATOM   625  C  CA  . ASN   A 1 162 ? -19.11314 12.41058  -23.73385 1.000 12.25917 ? 162 ASN   A CA  1 
ATOM   626  C  C   . ASN   A 1 162 ? -18.36919 11.55219  -22.71754 1.000 11.97952 ? 162 ASN   A C   1 
ATOM   627  O  O   . ASN   A 1 162 ? -17.15718 11.34781  -22.85228 1.000 10.14589 ? 162 ASN   A O   1 
ATOM   628  C  CB  . ASN   A 1 162 ? -18.98496 13.89099  -23.37734 1.000 13.14223 ? 162 ASN   A CB  1 
ATOM   629  C  CG  . ASN   A 1 162 ? -19.68772 14.23889  -22.08172 1.000 16.05188 ? 162 ASN   A CG  1 
ATOM   630  O  OD1 . ASN   A 1 162 ? -20.71377 13.65008  -21.74066 1.000 14.17260 ? 162 ASN   A OD1 1 
ATOM   631  N  ND2 . ASN   A 1 162 ? -19.13569 15.19778  -21.34939 1.000 16.38340 ? 162 ASN   A ND2 1 
ATOM   632  N  N   . ILE   A 1 163 ? -19.06480 11.04520  -21.69665 1.000 9.66462  ? 163 ILE   A N   1 
ATOM   633  C  CA  . ILE   A 1 163 ? -18.40414 10.17802  -20.72522 1.000 10.25112 ? 163 ILE   A CA  1 
ATOM   634  C  C   . ILE   A 1 163 ? -17.95397 8.88442   -21.39014 1.000 9.11578  ? 163 ILE   A C   1 
ATOM   635  O  O   . ILE   A 1 163 ? -16.83740 8.40603   -21.15714 1.000 9.25845  ? 163 ILE   A O   1 
ATOM   636  C  CB  . ILE   A 1 163 ? -19.32627 9.90081   -19.52476 1.000 12.11982 ? 163 ILE   A CB  1 
ATOM   637  C  CG1 . ILE   A 1 163 ? -19.88485 11.20633  -18.95933 1.000 8.72459  ? 163 ILE   A CG1 1 
ATOM   638  C  CG2 . ILE   A 1 163 ? -18.57010 9.15052   -18.44124 1.000 10.31432 ? 163 ILE   A CG2 1 
ATOM   639  C  CD1 . ILE   A 1 163 ? -20.90615 10.99914  -17.85577 1.000 10.92280 ? 163 ILE   A CD1 1 
ATOM   640  N  N   . HIS   A 1 164 ? -18.81436 8.29787   -22.22575 1.000 9.74022  ? 164 HIS   A N   1 
ATOM   641  C  CA  . HIS   A 1 164 ? -18.43071 7.10331   -22.96992 1.000 10.33612 ? 164 HIS   A CA  1 
ATOM   642  C  C   . HIS   A 1 164 ? -17.25007 7.38420   -23.89028 1.000 10.91985 ? 164 HIS   A C   1 
ATOM   643  O  O   . HIS   A 1 164 ? -16.33684 6.55886   -24.01172 1.000 7.71912  ? 164 HIS   A O   1 
ATOM   644  C  CB  . HIS   A 1 164 ? -19.62411 6.58586   -23.76975 1.000 9.01111  ? 164 HIS   A CB  1 
ATOM   645  C  CG  . HIS   A 1 164 ? -19.27399 5.51418   -24.75248 1.000 10.38526 ? 164 HIS   A CG  1 
ATOM   646  N  ND1 . HIS   A 1 164 ? -18.78373 4.28406   -24.37130 1.000 11.80174 ? 164 HIS   A ND1 1 
ATOM   647  C  CD2 . HIS   A 1 164 ? -19.33938 5.49094   -26.10439 1.000 10.10888 ? 164 HIS   A CD2 1 
ATOM   648  C  CE1 . HIS   A 1 164 ? -18.56844 3.54676   -25.44616 1.000 10.83381 ? 164 HIS   A CE1 1 
ATOM   649  N  NE2 . HIS   A 1 164 ? -18.89530 4.25653   -26.51081 1.000 9.18904  ? 164 HIS   A NE2 1 
ATOM   650  N  N   . ALA   A 1 165 ? -17.25008 8.54954   -24.54305 1.000 8.71403  ? 165 ALA   A N   1 
ATOM   651  C  CA  . ALA   A 1 165 ? -16.13976 8.91330   -25.41746 1.000 10.15290 ? 165 ALA   A CA  1 
ATOM   652  C  C   . ALA   A 1 165 ? -14.83476 9.02105   -24.64014 1.000 9.65044  ? 165 ALA   A C   1 
ATOM   653  O  O   . ALA   A 1 165 ? -13.80022 8.50260   -25.07517 1.000 9.04116  ? 165 ALA   A O   1 
ATOM   654  C  CB  . ALA   A 1 165 ? -16.44518 10.22825  -26.13176 1.000 10.43888 ? 165 ALA   A CB  1 
ATOM   655  N  N   . ALA   A 1 166 ? -14.86344 9.69187   -23.48638 1.000 10.58939 ? 166 ALA   A N   1 
ATOM   656  C  CA  . ALA   A 1 166 ? -13.66393 9.79820   -22.66234 1.000 9.97490  ? 166 ALA   A CA  1 
ATOM   657  C  C   . ALA   A 1 166 ? -13.20847 8.42955   -22.17356 1.000 9.98620  ? 166 ALA   A C   1 
ATOM   658  O  O   . ALA   A 1 166 ? -12.00667 8.13602   -22.15170 1.000 8.53847  ? 166 ALA   A O   1 
ATOM   659  C  CB  . ALA   A 1 166 ? -13.92445 10.73087  -21.48052 1.000 11.31460 ? 166 ALA   A CB  1 
ATOM   660  N  N   . ASP   A 1 167 ? -14.15951 7.57885   -21.78010 1.000 9.63258  ? 167 ASP   A N   1 
ATOM   661  C  CA  . ASP   A 1 167 ? -13.82403 6.23912   -21.30976 1.000 10.29067 ? 167 ASP   A CA  1 
ATOM   662  C  C   . ASP   A 1 167 ? -13.13944 5.42257   -22.40033 1.000 8.98372  ? 167 ASP   A C   1 
ATOM   663  O  O   . ASP   A 1 167 ? -12.17082 4.70220   -22.13137 1.000 10.29156 ? 167 ASP   A O   1 
ATOM   664  C  CB  . ASP   A 1 167 ? -15.09194 5.53782   -20.82013 1.000 11.12081 ? 167 ASP   A CB  1 
ATOM   665  C  CG  . ASP   A 1 167 ? -14.85367 4.09232   -20.43894 1.000 13.36823 ? 167 ASP   A CG  1 
ATOM   666  O  OD1 . ASP   A 1 167 ? -13.87752 3.81993   -19.70772 1.000 10.17964 ? 167 ASP   A OD1 1 
ATOM   667  O  OD2 . ASP   A 1 167 ? -15.65129 3.22966   -20.86624 1.000 11.58522 ? 167 ASP   A OD2 1 
ATOM   668  N  N   . VAL   A 1 168 ? -13.62492 5.52727   -23.63976 1.000 8.37926  ? 168 VAL   A N   1 
ATOM   669  C  CA  . VAL   A 1 168 ? -13.03863 4.76514   -24.73909 1.000 9.07171  ? 168 VAL   A CA  1 
ATOM   670  C  C   . VAL   A 1 168 ? -11.67565 5.33155   -25.11781 1.000 9.68830  ? 168 VAL   A C   1 
ATOM   671  O  O   . VAL   A 1 168 ? -10.74728 4.58213   -25.44658 1.000 7.98661  ? 168 VAL   A O   1 
ATOM   672  C  CB  . VAL   A 1 168 ? -14.00436 4.73927   -25.93808 1.000 7.83361  ? 168 VAL   A CB  1 
ATOM   673  C  CG1 . VAL   A 1 168 ? -13.32237 4.17353   -27.17460 1.000 10.77072 ? 168 VAL   A CG1 1 
ATOM   674  C  CG2 . VAL   A 1 168 ? -15.23218 3.91802   -25.59624 1.000 8.31333  ? 168 VAL   A CG2 1 
ATOM   675  N  N   . VAL   A 1 169 ? -11.53356 6.65982   -25.08261 1.000 7.20930  ? 169 VAL   A N   1 
ATOM   676  C  CA  . VAL   A 1 169 ? -10.22330 7.27872   -25.27979 1.000 9.94460  ? 169 VAL   A CA  1 
ATOM   677  C  C   . VAL   A 1 169 ? -9.22274  6.71972   -24.28136 1.000 10.78124 ? 169 VAL   A C   1 
ATOM   678  O  O   . VAL   A 1 169 ? -8.14120  6.24557   -24.64872 1.000 13.41823 ? 169 VAL   A O   1 
ATOM   679  C  CB  . VAL   A 1 169 ? -10.32204 8.80816   -25.15058 1.000 13.68162 ? 169 VAL   A CB  1 
ATOM   680  C  CG1 . VAL   A 1 169 ? -8.93351  9.40505   -25.02324 1.000 10.94294 ? 169 VAL   A CG1 1 
ATOM   681  C  CG2 . VAL   A 1 169 ? -11.03032 9.39116   -26.33563 1.000 9.09986  ? 169 VAL   A CG2 1 
ATOM   682  N  N   . GLN   A 1 170 ? -9.57899  6.76664   -22.99759 1.000 9.50595  ? 170 GLN   A N   1 
ATOM   683  C  CA  . GLN   A 1 170 ? -8.64659  6.37146   -21.95028 1.000 11.10248 ? 170 GLN   A CA  1 
ATOM   684  C  C   . GLN   A 1 170 ? -8.36078  4.87555   -21.99699 1.000 12.09616 ? 170 GLN   A C   1 
ATOM   685  O  O   . GLN   A 1 170 ? -7.23067  4.44701   -21.73680 1.000 9.31119  ? 170 GLN   A O   1 
ATOM   686  C  CB  . GLN   A 1 170 ? -9.20239  6.78489   -20.58891 1.000 9.15826  ? 170 GLN   A CB  1 
ATOM   687  C  CG  . GLN   A 1 170 ? -8.20532  6.68716   -19.45547 1.000 15.51116 ? 170 GLN   A CG  1 
ATOM   688  C  CD  . GLN   A 1 170 ? -8.29571  5.37258   -18.71166 1.000 17.68390 ? 170 GLN   A CD  1 
ATOM   689  O  OE1 . GLN   A 1 170 ? -9.34510  4.72893   -18.69048 1.000 11.81151 ? 170 GLN   A OE1 1 
ATOM   690  N  NE2 . GLN   A 1 170 ? -7.19413  4.96720   -18.09199 1.000 13.51448 ? 170 GLN   A NE2 1 
ATOM   691  N  N   . SER   A 1 171 ? -9.36755  4.06560   -22.33275 1.000 10.79346 ? 171 SER   A N   1 
ATOM   692  C  CA  . SER   A 1 171 ? -9.14146  2.62929   -22.45833 1.000 11.96130 ? 171 SER   A CA  1 
ATOM   693  C  C   . SER   A 1 171 ? -8.22683  2.31796   -23.63600 1.000 12.61834 ? 171 SER   A C   1 
ATOM   694  O  O   . SER   A 1 171 ? -7.30419  1.50385   -23.51287 1.000 11.56372 ? 171 SER   A O   1 
ATOM   695  C  CB  . SER   A 1 171 ? -10.47466 1.89666   -22.60109 1.000 11.28277 ? 171 SER   A CB  1 
ATOM   696  O  OG  . SER   A 1 171 ? -11.30300 2.12408   -21.47344 1.000 11.10599 ? 171 SER   A OG  1 
ATOM   697  N  N   . THR   A 1 172 ? -8.46916  2.95478   -24.78574 1.000 10.28768 ? 172 THR   A N   1 
ATOM   698  C  CA  . THR   A 1 172 ? -7.55948  2.81366   -25.91880 1.000 9.20990  ? 172 THR   A CA  1 
ATOM   699  C  C   . THR   A 1 172 ? -6.15395  3.26928   -25.54862 1.000 14.56184 ? 172 THR   A C   1 
ATOM   700  O  O   . THR   A 1 172 ? -5.16346  2.64098   -25.94170 1.000 10.48692 ? 172 THR   A O   1 
ATOM   701  C  CB  . THR   A 1 172 ? -8.08322  3.60938   -27.11645 1.000 10.32788 ? 172 THR   A CB  1 
ATOM   702  O  OG1 . THR   A 1 172 ? -9.27168  2.99077   -27.62363 1.000 11.16422 ? 172 THR   A OG1 1 
ATOM   703  C  CG2 . THR   A 1 172 ? -7.04021  3.67079   -28.22381 1.000 11.63493 ? 172 THR   A CG2 1 
ATOM   704  N  N   . HIS   A 1 173 ? -6.05206  4.35690   -24.78059 1.000 13.35612 ? 173 HIS   A N   1 
ATOM   705  C  CA  . HIS   A 1 173 ? -4.75241  4.83347   -24.31910 1.000 13.66348 ? 173 HIS   A CA  1 
ATOM   706  C  C   . HIS   A 1 173 ? -4.01704  3.76158   -23.52355 1.000 14.28079 ? 173 HIS   A C   1 
ATOM   707  O  O   . HIS   A 1 173 ? -2.80825  3.56772   -23.69856 1.000 11.69386 ? 173 HIS   A O   1 
ATOM   708  C  CB  . HIS   A 1 173 ? -4.93927  6.09557   -23.47838 1.000 12.43874 ? 173 HIS   A CB  1 
ATOM   709  C  CG  . HIS   A 1 173 ? -3.72219  6.49888   -22.70688 1.000 13.46748 ? 173 HIS   A CG  1 
ATOM   710  N  ND1 . HIS   A 1 173 ? -2.55671  6.91084   -23.31519 1.000 16.34630 ? 173 HIS   A ND1 1 
ATOM   711  C  CD2 . HIS   A 1 173 ? -3.49139  6.55678   -21.37397 1.000 14.30557 ? 173 HIS   A CD2 1 
ATOM   712  C  CE1 . HIS   A 1 173 ? -1.65944  7.20395   -22.39093 1.000 17.15766 ? 173 HIS   A CE1 1 
ATOM   713  N  NE2 . HIS   A 1 173 ? -2.20153  6.99751   -21.20435 1.000 14.11324 ? 173 HIS   A NE2 1 
ATOM   714  N  N   . VAL   A 1 174 ? -4.73047  3.05113   -22.64830 1.000 12.88786 ? 174 VAL   A N   1 
ATOM   715  C  CA  . VAL   A 1 174 ? -4.09987  2.00378   -21.84972 1.000 11.60338 ? 174 VAL   A CA  1 
ATOM   716  C  C   . VAL   A 1 174 ? -3.70700  0.82432   -22.73065 1.000 16.38746 ? 174 VAL   A C   1 
ATOM   717  O  O   . VAL   A 1 174 ? -2.60194  0.28100   -22.61318 1.000 15.67385 ? 174 VAL   A O   1 
ATOM   718  C  CB  . VAL   A 1 174 ? -5.03193  1.56874   -20.70514 1.000 13.23816 ? 174 VAL   A CB  1 
ATOM   719  C  CG1 . VAL   A 1 174 ? -4.44775  0.37330   -19.96710 1.000 12.06041 ? 174 VAL   A CG1 1 
ATOM   720  C  CG2 . VAL   A 1 174 ? -5.25913  2.72613   -19.74832 1.000 16.60025 ? 174 VAL   A CG2 1 
ATOM   721  N  N   . LEU   A 1 175 ? -4.60466  0.41404   -23.63035 1.000 12.04000 ? 175 LEU   A N   1 
ATOM   722  C  CA  . LEU   A 1 175 ? -4.31999  -0.72946  -24.49078 1.000 14.26546 ? 175 LEU   A CA  1 
ATOM   723  C  C   . LEU   A 1 175 ? -3.14016  -0.45896  -25.41513 1.000 16.57116 ? 175 LEU   A C   1 
ATOM   724  O  O   . LEU   A 1 175 ? -2.39218  -1.38394  -25.75300 1.000 17.96464 ? 175 LEU   A O   1 
ATOM   725  C  CB  . LEU   A 1 175 ? -5.56488  -1.09549  -25.29986 1.000 12.70900 ? 175 LEU   A CB  1 
ATOM   726  C  CG  . LEU   A 1 175 ? -6.76873  -1.55766  -24.47481 1.000 13.16612 ? 175 LEU   A CG  1 
ATOM   727  C  CD1 . LEU   A 1 175 ? -7.94397  -1.91756  -25.37127 1.000 9.38401  ? 175 LEU   A CD1 1 
ATOM   728  C  CD2 . LEU   A 1 175 ? -6.38276  -2.73336  -23.58983 1.000 13.37466 ? 175 LEU   A CD2 1 
ATOM   729  N  N   . LEU   A 1 176 ? -2.95098  0.79808   -25.82406 1.000 13.87585 ? 176 LEU   A N   1 
ATOM   730  C  CA  . LEU   A 1 176 ? -1.80843  1.14189   -26.66412 1.000 16.00157 ? 176 LEU   A CA  1 
ATOM   731  C  C   . LEU   A 1 176 ? -0.48504  0.92666   -25.94084 1.000 18.11296 ? 176 LEU   A C   1 
ATOM   732  O  O   . LEU   A 1 176 ? 0.53881   0.67648   -26.58658 1.000 16.05481 ? 176 LEU   A O   1 
ATOM   733  C  CB  . LEU   A 1 176 ? -1.91605  2.59424   -27.13055 1.000 11.33035 ? 176 LEU   A CB  1 
ATOM   734  C  CG  . LEU   A 1 176 ? -2.79657  2.88751   -28.34383 1.000 15.40615 ? 176 LEU   A CG  1 
ATOM   735  C  CD1 . LEU   A 1 176 ? -3.06531  4.37772   -28.46256 1.000 12.48704 ? 176 LEU   A CD1 1 
ATOM   736  C  CD2 . LEU   A 1 176 ? -2.13306  2.36590   -29.60569 1.000 18.10971 ? 176 LEU   A CD2 1 
ATOM   737  N  N   . SER   A 1 177 ? -0.48064  1.02321   -24.61257 1.000 18.77866 ? 177 SER   A N   1 
ATOM   738  C  CA  . SER   A 1 177 ? 0.74000   0.93689   -23.82185 1.000 22.50779 ? 177 SER   A CA  1 
ATOM   739  C  C   . SER   A 1 177 ? 1.05787   -0.48158  -23.36886 1.000 23.10650 ? 177 SER   A C   1 
ATOM   740  O  O   . SER   A 1 177 ? 1.95672   -0.66618  -22.54099 1.000 24.17125 ? 177 SER   A O   1 
ATOM   741  C  CB  . SER   A 1 177 ? 0.64072   1.85136   -22.59779 1.000 17.18698 ? 177 SER   A CB  1 
ATOM   742  O  OG  . SER   A 1 177 ? 0.67003   3.21808   -22.96822 1.000 27.42302 ? 177 SER   A OG  1 
ATOM   743  N  N   . THR   A 1 178 ? 0.34734   -1.47858  -23.88296 1.000 16.35675 ? 178 THR   A N   1 
ATOM   744  C  CA  . THR   A 1 178 ? 0.56546   -2.84109  -23.42995 1.000 20.72175 ? 178 THR   A CA  1 
ATOM   745  C  C   . THR   A 1 178 ? 1.95891   -3.31072  -23.85115 1.000 25.67412 ? 178 THR   A C   1 
ATOM   746  O  O   . THR   A 1 178 ? 2.43432   -2.95693  -24.93665 1.000 19.74427 ? 178 THR   A O   1 
ATOM   747  C  CB  . THR   A 1 178 ? -0.52384  -3.76829  -23.98097 1.000 24.76621 ? 178 THR   A CB  1 
ATOM   748  O  OG1 . THR   A 1 178 ? -0.62279  -4.93030  -23.15641 1.000 27.67737 ? 178 THR   A OG1 1 
ATOM   749  C  CG2 . THR   A 1 178 ? -0.23220  -4.20194  -25.40491 1.000 20.67992 ? 178 THR   A CG2 1 
ATOM   750  N  N   . PRO   A 1 179 ? 2.65979   -4.05658  -22.99105 1.000 26.07422 ? 179 PRO   A N   1 
ATOM   751  C  CA  . PRO   A 1 179 ? 4.04902   -4.43653  -23.30728 1.000 26.85208 ? 179 PRO   A CA  1 
ATOM   752  C  C   . PRO   A 1 179 ? 4.21442   -5.14431  -24.64058 1.000 26.12918 ? 179 PRO   A C   1 
ATOM   753  O  O   . PRO   A 1 179 ? 5.20982   -4.91352  -25.33817 1.000 25.57446 ? 179 PRO   A O   1 
ATOM   754  C  CB  . PRO   A 1 179 ? 4.42528   -5.34751  -22.13241 1.000 24.73959 ? 179 PRO   A CB  1 
ATOM   755  C  CG  . PRO   A 1 179 ? 3.60678   -4.83417  -21.00117 1.000 29.70220 ? 179 PRO   A CG  1 
ATOM   756  C  CD  . PRO   A 1 179 ? 2.29521   -4.39771  -21.60459 1.000 25.36902 ? 179 PRO   A CD  1 
ATOM   757  N  N   . ALA   A 1 180 ? 3.25791   -5.99219  -25.02282 1.000 22.20714 ? 180 ALA   A N   1 
ATOM   758  C  CA  . ALA   A 1 180 ? 3.36506   -6.72822  -26.27611 1.000 21.17828 ? 180 ALA   A CA  1 
ATOM   759  C  C   . ALA   A 1 180 ? 3.33475   -5.82586  -27.50416 1.000 21.96417 ? 180 ALA   A C   1 
ATOM   760  O  O   . ALA   A 1 180 ? 3.56227   -6.32066  -28.61319 1.000 24.86565 ? 180 ALA   A O   1 
ATOM   761  C  CB  . ALA   A 1 180 ? 2.24338   -7.76562  -26.37541 1.000 16.65599 ? 180 ALA   A CB  1 
ATOM   762  N  N   . LEU   A 1 181 ? 3.07250   -4.52659  -27.34225 1.000 21.20055 ? 181 LEU   A N   1 
ATOM   763  C  CA  . LEU   A 1 181 ? 2.95341   -3.60894  -28.46964 1.000 21.21913 ? 181 LEU   A CA  1 
ATOM   764  C  C   . LEU   A 1 181 ? 3.95445   -2.46002  -28.42558 1.000 22.07715 ? 181 LEU   A C   1 
ATOM   765  O  O   . LEU   A 1 181 ? 3.82927   -1.51788  -29.21886 1.000 22.58616 ? 181 LEU   A O   1 
ATOM   766  C  CB  . LEU   A 1 181 ? 1.53240   -3.04235  -28.54683 1.000 19.82437 ? 181 LEU   A CB  1 
ATOM   767  C  CG  . LEU   A 1 181 ? 0.42348   -4.01607  -28.93651 1.000 19.71050 ? 181 LEU   A CG  1 
ATOM   768  C  CD1 . LEU   A 1 181 ? -0.92223  -3.32967  -28.81414 1.000 17.93145 ? 181 LEU   A CD1 1 
ATOM   769  C  CD2 . LEU   A 1 181 ? 0.64007   -4.53155  -30.34662 1.000 19.15808 ? 181 LEU   A CD2 1 
ATOM   770  N  N   . GLU   A 1 182 ? 4.94105   -2.50744  -27.53482 1.000 21.80768 ? 182 GLU   A N   1 
ATOM   771  C  CA  . GLU   A 1 182 ? 5.87789   -1.39921  -27.40228 1.000 24.65279 ? 182 GLU   A CA  1 
ATOM   772  C  C   . GLU   A 1 182 ? 6.73535   -1.25571  -28.65578 1.000 22.58350 ? 182 GLU   A C   1 
ATOM   773  O  O   . GLU   A 1 182 ? 7.29817   -2.23652  -29.15276 1.000 23.33701 ? 182 GLU   A O   1 
ATOM   774  C  CB  . GLU   A 1 182 ? 6.75258   -1.59658  -26.16568 1.000 28.48304 ? 182 GLU   A CB  1 
ATOM   775  C  CG  . GLU   A 1 182 ? 5.94043   -1.82542  -24.90211 1.000 34.46605 ? 182 GLU   A CG  1 
ATOM   776  C  CD  . GLU   A 1 182 ? 6.80297   -1.93142  -23.65989 1.000 48.45586 ? 182 GLU   A CD  1 
ATOM   777  O  OE1 . GLU   A 1 182 ? 6.24606   -1.96605  -22.54364 1.000 46.74297 ? 182 GLU   A OE1 1 
ATOM   778  O  OE2 . GLU   A 1 182 ? 8.04167   -1.96043  -23.79514 1.000 42.37408 ? 182 GLU   A OE2 1 
ATOM   779  N  N   . ALA   A 1 183 ? 6.81737   -0.02466  -29.16793 1.000 20.52214 ? 183 ALA   A N   1 
ATOM   780  C  CA  . ALA   A 1 183 ? 7.52302   0.35174   -30.39238 1.000 29.35489 ? 183 ALA   A CA  1 
ATOM   781  C  C   . ALA   A 1 183 ? 6.88961   -0.22143  -31.65592 1.000 23.52185 ? 183 ALA   A C   1 
ATOM   782  O  O   . ALA   A 1 183 ? 7.50754   -0.15915  -32.72810 1.000 31.55640 ? 183 ALA   A O   1 
ATOM   783  C  CB  . ALA   A 1 183 ? 9.00605   -0.03980  -30.35071 1.000 28.23096 ? 183 ALA   A CB  1 
ATOM   784  N  N   . VAL   A 1 184 ? 5.67566   -0.76955  -31.57358 1.000 23.33840 ? 184 VAL   A N   1 
ATOM   785  C  CA  . VAL   A 1 184 ? 5.01557   -1.29747  -32.76560 1.000 20.10966 ? 184 VAL   A CA  1 
ATOM   786  C  C   . VAL   A 1 184 ? 4.46635   -0.16920  -33.62499 1.000 20.05200 ? 184 VAL   A C   1 
ATOM   787  O  O   . VAL   A 1 184 ? 4.76349   -0.07610  -34.82148 1.000 23.52646 ? 184 VAL   A O   1 
ATOM   788  C  CB  . VAL   A 1 184 ? 3.89526   -2.28156  -32.38203 1.000 20.89287 ? 184 VAL   A CB  1 
ATOM   789  C  CG1 . VAL   A 1 184 ? 3.10936   -2.68517  -33.61934 1.000 18.23752 ? 184 VAL   A CG1 1 
ATOM   790  C  CG2 . VAL   A 1 184 ? 4.46311   -3.49796  -31.71984 1.000 25.16513 ? 184 VAL   A CG2 1 
ATOM   791  N  N   . PHE   A 1 185 ? 3.64701   0.69197   -33.03483 1.000 21.36935 ? 185 PHE   A N   1 
ATOM   792  C  CA  . PHE   A 1 185 ? 2.89081   1.68047   -33.78395 1.000 19.46166 ? 185 PHE   A CA  1 
ATOM   793  C  C   . PHE   A 1 185 ? 3.61082   3.02180   -33.80043 1.000 19.22998 ? 185 PHE   A C   1 
ATOM   794  O  O   . PHE   A 1 185 ? 4.26994   3.40799   -32.83221 1.000 18.78717 ? 185 PHE   A O   1 
ATOM   795  C  CB  . PHE   A 1 185 ? 1.48763   1.84353   -33.19656 1.000 14.17650 ? 185 PHE   A CB  1 
ATOM   796  C  CG  . PHE   A 1 185 ? 0.63293   0.61687   -33.33404 1.000 12.49671 ? 185 PHE   A CG  1 
ATOM   797  C  CD1 . PHE   A 1 185 ? 0.15493   0.22707   -34.57463 1.000 15.74833 ? 185 PHE   A CD1 1 
ATOM   798  C  CD2 . PHE   A 1 185 ? 0.31020   -0.14945  -32.22557 1.000 14.94140 ? 185 PHE   A CD2 1 
ATOM   799  C  CE1 . PHE   A 1 185 ? -0.63119  -0.90529  -34.70871 1.000 13.16883 ? 185 PHE   A CE1 1 
ATOM   800  C  CE2 . PHE   A 1 185 ? -0.47696  -1.28251  -32.35130 1.000 14.07148 ? 185 PHE   A CE2 1 
ATOM   801  C  CZ  . PHE   A 1 185 ? -0.94777  -1.66074  -33.59504 1.000 9.60374  ? 185 PHE   A CZ  1 
ATOM   802  N  N   . THR   A 1 186 ? 3.48337   3.72563   -34.92273 1.000 17.69868 ? 186 THR   A N   1 
ATOM   803  C  CA  . THR   A 1 186 ? 4.06192   5.05208   -35.04374 1.000 18.87025 ? 186 THR   A CA  1 
ATOM   804  C  C   . THR   A 1 186 ? 3.27671   6.04928   -34.19760 1.000 16.38025 ? 186 THR   A C   1 
ATOM   805  O  O   . THR   A 1 186 ? 2.17341   5.77143   -33.71754 1.000 15.69276 ? 186 THR   A O   1 
ATOM   806  C  CB  . THR   A 1 186 ? 4.07092   5.51185   -36.50141 1.000 20.83282 ? 186 THR   A CB  1 
ATOM   807  O  OG1 . THR   A 1 186 ? 2.72268   5.62244   -36.97658 1.000 21.31273 ? 186 THR   A OG1 1 
ATOM   808  C  CG2 . THR   A 1 186 ? 4.83244   4.52503   -37.36982 1.000 17.28469 ? 186 THR   A CG2 1 
ATOM   809  N  N   . ASP   A 1 187 ? 3.86786   7.23259   -34.01667 1.000 15.72144 ? 187 ASP   A N   1 
ATOM   810  C  CA  . ASP   A 1 187 ? 3.15093   8.31837   -33.35718 1.000 19.12248 ? 187 ASP   A CA  1 
ATOM   811  C  C   . ASP   A 1 187 ? 1.87533   8.66540   -34.11306 1.000 16.45886 ? 187 ASP   A C   1 
ATOM   812  O  O   . ASP   A 1 187 ? 0.84879   8.98675   -33.50273 1.000 14.35123 ? 187 ASP   A O   1 
ATOM   813  C  CB  . ASP   A 1 187 ? 4.05160   9.54751   -33.23562 1.000 18.53703 ? 187 ASP   A CB  1 
ATOM   814  C  CG  . ASP   A 1 187 ? 5.31771   9.26841   -32.45067 1.000 24.32316 ? 187 ASP   A CG  1 
ATOM   815  O  OD1 . ASP   A 1 187 ? 5.23991   8.55743   -31.42645 1.000 22.67973 ? 187 ASP   A OD1 1 
ATOM   816  O  OD2 . ASP   A 1 187 ? 6.39098   9.76132   -32.85806 1.000 30.06138 ? 187 ASP   A OD2 1 
ATOM   817  N  N   . LEU   A 1 188 ? 1.91934   8.59348   -35.44563 1.000 13.44121 ? 188 LEU   A N   1 
ATOM   818  C  CA  . LEU   A 1 188 ? 0.73919   8.90299   -36.24530 1.000 15.04776 ? 188 LEU   A CA  1 
ATOM   819  C  C   . LEU   A 1 188 ? -0.35506  7.86074   -36.04584 1.000 16.90070 ? 188 LEU   A C   1 
ATOM   820  O  O   . LEU   A 1 188 ? -1.54011  8.20566   -35.96875 1.000 11.69805 ? 188 LEU   A O   1 
ATOM   821  C  CB  . LEU   A 1 188 ? 1.11912   9.00705   -37.72176 1.000 13.41904 ? 188 LEU   A CB  1 
ATOM   822  C  CG  . LEU   A 1 188 ? 0.02111   9.55865   -38.63301 1.000 16.91309 ? 188 LEU   A CG  1 
ATOM   823  C  CD1 . LEU   A 1 188 ? -0.27655  11.00899  -38.28548 1.000 13.98509 ? 188 LEU   A CD1 1 
ATOM   824  C  CD2 . LEU   A 1 188 ? 0.39902   9.42213   -40.09867 1.000 14.92510 ? 188 LEU   A CD2 1 
ATOM   825  N  N   . GLU   A 1 189 ? 0.01978   6.58078   -35.96658 1.000 13.12463 ? 189 GLU   A N   1 
ATOM   826  C  CA  . GLU   A 1 189 ? -0.96804  5.53765   -35.70577 1.000 13.54669 ? 189 GLU   A CA  1 
ATOM   827  C  C   . GLU   A 1 189 ? -1.55558  5.67402   -34.30712 1.000 15.24137 ? 189 GLU   A C   1 
ATOM   828  O  O   . GLU   A 1 189 ? -2.76508  5.49941   -34.11569 1.000 12.20485 ? 189 GLU   A O   1 
ATOM   829  C  CB  . GLU   A 1 189 ? -0.33689  4.15860   -35.89072 1.000 15.10549 ? 189 GLU   A CB  1 
ATOM   830  C  CG  . GLU   A 1 189 ? 0.02555   3.82947   -37.32623 1.000 13.19177 ? 189 GLU   A CG  1 
ATOM   831  C  CD  . GLU   A 1 189 ? 0.97039   2.64986   -37.42652 1.000 18.39933 ? 189 GLU   A CD  1 
ATOM   832  O  OE1 . GLU   A 1 189 ? 1.86268   2.52993   -36.56540 1.000 17.26730 ? 189 GLU   A OE1 1 
ATOM   833  O  OE2 . GLU   A 1 189 ? 0.82111   1.83865   -38.36186 1.000 19.60640 ? 189 GLU   A OE2 1 
ATOM   834  N  N   . ILE   A 1 190 ? -0.71182  5.97988   -33.31851 1.000 11.89739 ? 190 ILE   A N   1 
ATOM   835  C  CA  . ILE   A 1 190 ? -1.19867  6.23473   -31.96464 1.000 16.08773 ? 190 ILE   A CA  1 
ATOM   836  C  C   . ILE   A 1 190 ? -2.16152  7.41447   -31.96518 1.000 14.81895 ? 190 ILE   A C   1 
ATOM   837  O  O   . ILE   A 1 190 ? -3.23293  7.36867   -31.34819 1.000 14.83643 ? 190 ILE   A O   1 
ATOM   838  C  CB  . ILE   A 1 190 ? -0.01618  6.47291   -31.00820 1.000 14.50739 ? 190 ILE   A CB  1 
ATOM   839  C  CG1 . ILE   A 1 190 ? 0.78807   5.18607   -30.82116 1.000 15.36544 ? 190 ILE   A CG1 1 
ATOM   840  C  CG2 . ILE   A 1 190 ? -0.50305  7.00624   -29.67092 1.000 12.11045 ? 190 ILE   A CG2 1 
ATOM   841  C  CD1 . ILE   A 1 190 ? 2.12143   5.39546   -30.13485 1.000 12.69708 ? 190 ILE   A CD1 1 
ATOM   842  N  N   . LEU   A 1 191 ? -1.79056  8.49011   -32.66381 1.000 13.70299 ? 191 LEU   A N   1 
ATOM   843  C  CA  . LEU   A 1 191 ? -2.67330  9.64567   -32.77897 1.000 16.24454 ? 191 LEU   A CA  1 
ATOM   844  C  C   . LEU   A 1 191 ? -3.99123  9.26780   -33.44267 1.000 12.53095 ? 191 LEU   A C   1 
ATOM   845  O  O   . LEU   A 1 191 ? -5.06318  9.69426   -32.99758 1.000 13.03027 ? 191 LEU   A O   1 
ATOM   846  C  CB  . LEU   A 1 191 ? -1.97525  10.75698  -33.56329 1.000 14.19232 ? 191 LEU   A CB  1 
ATOM   847  C  CG  . LEU   A 1 191 ? -2.77716  12.03675  -33.80903 1.000 11.40971 ? 191 LEU   A CG  1 
ATOM   848  C  CD1 . LEU   A 1 191 ? -3.03616  12.76699  -32.50288 1.000 10.68323 ? 191 LEU   A CD1 1 
ATOM   849  C  CD2 . LEU   A 1 191 ? -2.06324  12.94471  -34.79981 1.000 13.24730 ? 191 LEU   A CD2 1 
ATOM   850  N  N   . ALA   A 1 192 ? -3.93045  8.46066   -34.50564 1.000 11.36015 ? 192 ALA   A N   1 
ATOM   851  C  CA  . ALA   A 1 192 ? -5.14742  8.04149   -35.19365 1.000 9.70441  ? 192 ALA   A CA  1 
ATOM   852  C  C   . ALA   A 1 192 ? -6.06224  7.24815   -34.26952 1.000 11.94497 ? 192 ALA   A C   1 
ATOM   853  O  O   . ALA   A 1 192 ? -7.27383  7.49021   -34.22755 1.000 13.11765 ? 192 ALA   A O   1 
ATOM   854  C  CB  . ALA   A 1 192 ? -4.79312  7.21787   -36.43160 1.000 12.10506 ? 192 ALA   A CB  1 
ATOM   855  N  N   . ALA   A 1 193 ? -5.49858  6.30214   -33.51384 1.000 10.60687 ? 193 ALA   A N   1 
ATOM   856  C  CA  . ALA   A 1 193 ? -6.31419  5.46464   -32.63930 1.000 12.96136 ? 193 ALA   A CA  1 
ATOM   857  C  C   . ALA   A 1 193 ? -6.96953  6.28301   -31.53360 1.000 12.60220 ? 193 ALA   A C   1 
ATOM   858  O  O   . ALA   A 1 193 ? -8.14967  6.08394   -31.22318 1.000 12.56726 ? 193 ALA   A O   1 
ATOM   859  C  CB  . ALA   A 1 193 ? -5.46230  4.34429   -32.04317 1.000 11.45174 ? 193 ALA   A CB  1 
ATOM   860  N  N   . ILE   A 1 194 ? -6.22276  7.20765   -30.92880 1.000 13.01888 ? 194 ILE   A N   1 
ATOM   861  C  CA  . ILE   A 1 194 ? -6.78071  8.02587   -29.85688 1.000 13.57664 ? 194 ILE   A CA  1 
ATOM   862  C  C   . ILE   A 1 194 ? -7.81333  9.00109   -30.40650 1.000 12.13742 ? 194 ILE   A C   1 
ATOM   863  O  O   . ILE   A 1 194 ? -8.88420  9.19062   -29.81598 1.000 12.33718 ? 194 ILE   A O   1 
ATOM   864  C  CB  . ILE   A 1 194 ? -5.65073  8.75182   -29.10772 1.000 12.24202 ? 194 ILE   A CB  1 
ATOM   865  C  CG1 . ILE   A 1 194 ? -4.80494  7.73491   -28.34173 1.000 13.75199 ? 194 ILE   A CG1 1 
ATOM   866  C  CG2 . ILE   A 1 194 ? -6.21529  9.81689   -28.17683 1.000 10.34210 ? 194 ILE   A CG2 1 
ATOM   867  C  CD1 . ILE   A 1 194 ? -3.48342  8.27684   -27.86797 1.000 18.65324 ? 194 ILE   A CD1 1 
ATOM   868  N  N   . PHE   A 1 195 ? -7.50945  9.63754   -31.53992 1.000 10.17648 ? 195 PHE   A N   1 
ATOM   869  C  CA  . PHE   A 1 195 ? -8.46941  10.54069  -32.16726 1.000 10.25232 ? 195 PHE   A CA  1 
ATOM   870  C  C   . PHE   A 1 195 ? -9.73088  9.79425   -32.57893 1.000 10.27461 ? 195 PHE   A C   1 
ATOM   871  O  O   . PHE   A 1 195 ? -10.84999 10.27682  -32.36736 1.000 8.70187  ? 195 PHE   A O   1 
ATOM   872  C  CB  . PHE   A 1 195 ? -7.83117  11.22551  -33.37596 1.000 10.20182 ? 195 PHE   A CB  1 
ATOM   873  C  CG  . PHE   A 1 195 ? -8.74636  12.18152  -34.08827 1.000 14.87928 ? 195 PHE   A CG  1 
ATOM   874  C  CD1 . PHE   A 1 195 ? -8.99050  13.44192  -33.56775 1.000 12.62688 ? 195 PHE   A CD1 1 
ATOM   875  C  CD2 . PHE   A 1 195 ? -9.35223  11.82606  -35.28381 1.000 14.18537 ? 195 PHE   A CD2 1 
ATOM   876  C  CE1 . PHE   A 1 195 ? -9.82757  14.33006  -34.22018 1.000 14.26138 ? 195 PHE   A CE1 1 
ATOM   877  C  CE2 . PHE   A 1 195 ? -10.19079 12.71038  -35.94375 1.000 12.50689 ? 195 PHE   A CE2 1 
ATOM   878  C  CZ  . PHE   A 1 195 ? -10.42795 13.96491  -35.40969 1.000 11.47010 ? 195 PHE   A CZ  1 
ATOM   879  N  N   . ALA   A 1 196 ? -9.56567  8.61000   -33.17404 1.000 10.17725 ? 196 ALA   A N   1 
ATOM   880  C  CA  . ALA   A 1 196 ? -10.71849 7.80524   -33.56391 1.000 11.82863 ? 196 ALA   A CA  1 
ATOM   881  C  C   . ALA   A 1 196 ? -11.58833 7.48215   -32.35737 1.000 9.44995  ? 196 ALA   A C   1 
ATOM   882  O  O   . ALA   A 1 196 ? -12.81751 7.59016   -32.41784 1.000 9.26867  ? 196 ALA   A O   1 
ATOM   883  C  CB  . ALA   A 1 196 ? -10.25650 6.52261   -34.25579 1.000 8.33050  ? 196 ALA   A CB  1 
ATOM   884  N  N   . SER   A 1 197 ? -10.96139 7.09756   -31.24296 1.000 8.05035  ? 197 SER   A N   1 
ATOM   885  C  CA  . SER   A 1 197 ? -11.71644 6.82206   -30.02495 1.000 11.28841 ? 197 SER   A CA  1 
ATOM   886  C  C   . SER   A 1 197 ? -12.50164 8.04731   -29.57120 1.000 11.22452 ? 197 SER   A C   1 
ATOM   887  O  O   . SER   A 1 197 ? -13.64124 7.92746   -29.10536 1.000 11.13935 ? 197 SER   A O   1 
ATOM   888  C  CB  . SER   A 1 197 ? -10.77037 6.35610   -28.91767 1.000 10.50354 ? 197 SER   A CB  1 
ATOM   889  O  OG  . SER   A 1 197 ? -10.07613 5.18024   -29.29387 1.000 12.34692 ? 197 SER   A OG  1 
ATOM   890  N  N   . ALA   A 1 198 ? -11.91315 9.23730   -29.71267 1.000 8.50031  ? 198 ALA   A N   1 
ATOM   891  C  CA  . ALA   A 1 198 ? -12.55780 10.44784  -29.21275 1.000 8.63749  ? 198 ALA   A CA  1 
ATOM   892  C  C   . ALA   A 1 198 ? -13.80961 10.79000  -30.00780 1.000 9.17341  ? 198 ALA   A C   1 
ATOM   893  O  O   . ALA   A 1 198 ? -14.81960 11.21160  -29.43259 1.000 7.72671  ? 198 ALA   A O   1 
ATOM   894  C  CB  . ALA   A 1 198 ? -11.57208 11.61417  -29.23926 1.000 8.10391  ? 198 ALA   A CB  1 
ATOM   895  N  N   . ILE   A 1 199 ? -13.76631 10.61766  -31.33099 1.000 8.72128  ? 199 ILE   A N   1 
ATOM   896  C  CA  . ILE   A 1 199 ? -14.89893 10.99189  -32.17231 1.000 7.37153  ? 199 ILE   A CA  1 
ATOM   897  C  C   . ILE   A 1 199 ? -15.84906 9.83637   -32.44853 1.000 9.91644  ? 199 ILE   A C   1 
ATOM   898  O  O   . ILE   A 1 199 ? -16.89808 10.05218  -33.07480 1.000 9.95256  ? 199 ILE   A O   1 
ATOM   899  C  CB  . ILE   A 1 199 ? -14.42054 11.55723  -33.52472 1.000 10.40653 ? 199 ILE   A CB  1 
ATOM   900  C  CG1 . ILE   A 1 199 ? -13.76345 10.45617  -34.36127 1.000 8.56086  ? 199 ILE   A CG1 1 
ATOM   901  C  CG2 . ILE   A 1 199 ? -13.44642 12.70434  -33.30958 1.000 9.56160  ? 199 ILE   A CG2 1 
ATOM   902  C  CD1 . ILE   A 1 199 ? -13.55141 10.83939  -35.81572 1.000 6.03717  ? 199 ILE   A CD1 1 
ATOM   903  N  N   . HIS   A 1 200 ? -15.53790 8.62547   -31.97559 1.000 9.39624  ? 200 HIS   A N   1 
ATOM   904  C  CA  . HIS   A 1 200 ? -16.15224 7.42124   -32.53009 1.000 9.56412  ? 200 HIS   A CA  1 
ATOM   905  C  C   . HIS   A 1 200 ? -17.65973 7.34630   -32.31350 1.000 8.88560  ? 200 HIS   A C   1 
ATOM   906  O  O   . HIS   A 1 200 ? -18.32024 6.54800   -32.98441 1.000 9.64442  ? 200 HIS   A O   1 
ATOM   907  C  CB  . HIS   A 1 200 ? -15.48626 6.16938   -31.95149 1.000 6.07706  ? 200 HIS   A CB  1 
ATOM   908  C  CG  . HIS   A 1 200 ? -16.11713 5.66833   -30.68996 1.000 12.03372 ? 200 HIS   A CG  1 
ATOM   909  N  ND1 . HIS   A 1 200 ? -15.75554 6.12697   -29.44126 1.000 9.60450  ? 200 HIS   A ND1 1 
ATOM   910  C  CD2 . HIS   A 1 200 ? -17.07485 4.73313   -30.48452 1.000 9.93852  ? 200 HIS   A CD2 1 
ATOM   911  C  CE1 . HIS   A 1 200 ? -16.47014 5.50253   -28.52191 1.000 11.60036 ? 200 HIS   A CE1 1 
ATOM   912  N  NE2 . HIS   A 1 200 ? -17.27813 4.65183   -29.12862 1.000 8.78160  ? 200 HIS   A NE2 1 
ATOM   913  N  N   . ASP   A 1 201 ? -18.22453 8.14258   -31.40075 1.000 9.21192  ? 201 ASP   A N   1 
ATOM   914  C  CA  . ASP   A 1 201 ? -19.66764 8.13652   -31.17782 1.000 7.72836  ? 201 ASP   A CA  1 
ATOM   915  C  C   . ASP   A 1 201 ? -20.25914 9.54186   -31.15774 1.000 10.11910 ? 201 ASP   A C   1 
ATOM   916  O  O   . ASP   A 1 201 ? -21.36653 9.72885   -30.64380 1.000 10.60665 ? 201 ASP   A O   1 
ATOM   917  C  CB  . ASP   A 1 201 ? -20.02310 7.41366   -29.87423 1.000 10.75385 ? 201 ASP   A CB  1 
ATOM   918  C  CG  . ASP   A 1 201 ? -20.20622 5.91973   -30.06137 1.000 10.02268 ? 201 ASP   A CG  1 
ATOM   919  O  OD1 . ASP   A 1 201 ? -20.51690 5.49005   -31.19156 1.000 8.88820  ? 201 ASP   A OD1 1 
ATOM   920  O  OD2 . ASP   A 1 201 ? -20.06291 5.17655   -29.06994 1.000 7.80018  ? 201 ASP   A OD2 1 
ATOM   921  N  N   . VAL   A 1 202 ? -19.55165 10.53421  -31.70402 1.000 9.51284  ? 202 VAL   A N   1 
ATOM   922  C  CA  . VAL   A 1 202 ? -19.99336 11.91578  -31.55949 1.000 12.40802 ? 202 VAL   A CA  1 
ATOM   923  C  C   . VAL   A 1 202 ? -21.32079 12.11767  -32.27864 1.000 13.46799 ? 202 VAL   A C   1 
ATOM   924  O  O   . VAL   A 1 202 ? -21.56897 11.54743  -33.35004 1.000 13.74018 ? 202 VAL   A O   1 
ATOM   925  C  CB  . VAL   A 1 202 ? -18.91297 12.88775  -32.06612 1.000 10.49454 ? 202 VAL   A CB  1 
ATOM   926  C  CG1 . VAL   A 1 202 ? -18.66597 12.70673  -33.55506 1.000 10.54715 ? 202 VAL   A CG1 1 
ATOM   927  C  CG2 . VAL   A 1 202 ? -19.29481 14.32871  -31.74441 1.000 10.18295 ? 202 VAL   A CG2 1 
ATOM   928  N  N   . ASP   A 1 203 ? -22.19607 12.91478  -31.65988 1.000 14.01046 ? 203 ASP   A N   1 
ATOM   929  C  CA  . ASP   A 1 203 ? -23.53834 13.20202  -32.16987 1.000 11.03162 ? 203 ASP   A CA  1 
ATOM   930  C  C   . ASP   A 1 203 ? -24.40110 11.94391  -32.23222 1.000 14.30278 ? 203 ASP   A C   1 
ATOM   931  O  O   . ASP   A 1 203 ? -25.30891 11.83841  -33.06043 1.000 11.80440 ? 203 ASP   A O   1 
ATOM   932  C  CB  . ASP   A 1 203 ? -23.48205 13.89582  -33.53483 1.000 13.05697 ? 203 ASP   A CB  1 
ATOM   933  C  CG  . ASP   A 1 203 ? -24.74338 14.67679  -33.84328 1.000 17.09529 ? 203 ASP   A CG  1 
ATOM   934  O  OD1 . ASP   A 1 203 ? -25.30131 15.29816  -32.91209 1.000 13.74403 ? 203 ASP   A OD1 1 
ATOM   935  O  OD2 . ASP   A 1 203 ? -25.17460 14.66588  -35.01587 1.000 10.86692 ? 203 ASP   A OD2 1 
ATOM   936  N  N   . HIS   A 1 204 ? -24.12645 10.98714  -31.35324 1.000 9.12833  ? 204 HIS   A N   1 
ATOM   937  C  CA  . HIS   A 1 204 ? -24.96964 9.80350   -31.24650 1.000 9.98683  ? 204 HIS   A CA  1 
ATOM   938  C  C   . HIS   A 1 204 ? -26.34009 10.20818  -30.71272 1.000 13.41870 ? 204 HIS   A C   1 
ATOM   939  O  O   . HIS   A 1 204 ? -26.42210 10.86152  -29.66552 1.000 11.46353 ? 204 HIS   A O   1 
ATOM   940  C  CB  . HIS   A 1 204 ? -24.32058 8.77476   -30.32189 1.000 9.71179  ? 204 HIS   A CB  1 
ATOM   941  C  CG  . HIS   A 1 204 ? -24.83210 7.38069   -30.50736 1.000 10.94906 ? 204 HIS   A CG  1 
ATOM   942  N  ND1 . HIS   A 1 204 ? -26.15402 7.04001   -30.31988 1.000 10.94126 ? 204 HIS   A ND1 1 
ATOM   943  C  CD2 . HIS   A 1 204 ? -24.19438 6.23733   -30.85348 1.000 9.85551  ? 204 HIS   A CD2 1 
ATOM   944  C  CE1 . HIS   A 1 204 ? -26.31019 5.74835   -30.54848 1.000 14.50298 ? 204 HIS   A CE1 1 
ATOM   945  N  NE2 . HIS   A 1 204 ? -25.13630 5.23794   -30.87440 1.000 9.39557  ? 204 HIS   A NE2 1 
ATOM   946  N  N   . PRO   A 1 205 ? -27.43077 9.86213   -31.40093 1.000 11.75657 ? 205 PRO   A N   1 
ATOM   947  C  CA  . PRO   A 1 205 ? -28.76505 10.25817  -30.93563 1.000 14.22867 ? 205 PRO   A CA  1 
ATOM   948  C  C   . PRO   A 1 205 ? -29.35376 9.35106   -29.86776 1.000 14.28695 ? 205 PRO   A C   1 
ATOM   949  O  O   . PRO   A 1 205 ? -30.46552 9.62114   -29.40062 1.000 12.29306 ? 205 PRO   A O   1 
ATOM   950  C  CB  . PRO   A 1 205 ? -29.59944 10.19702  -32.22238 1.000 15.35374 ? 205 PRO   A CB  1 
ATOM   951  C  CG  . PRO   A 1 205 ? -28.95757 9.11385   -33.01268 1.000 14.92126 ? 205 PRO   A CG  1 
ATOM   952  C  CD  . PRO   A 1 205 ? -27.47923 9.20187   -32.71609 1.000 13.46523 ? 205 PRO   A CD  1 
ATOM   953  N  N   . GLY   A 1 206 ? -28.65496 8.29186   -29.47202 1.000 13.79191 ? 206 GLY   A N   1 
ATOM   954  C  CA  . GLY   A 1 206 ? -29.15081 7.38461   -28.45927 1.000 15.99780 ? 206 GLY   A CA  1 
ATOM   955  C  C   . GLY   A 1 206 ? -30.00022 6.24354   -28.96929 1.000 16.44761 ? 206 GLY   A C   1 
ATOM   956  O  O   . GLY   A 1 206 ? -30.63322 5.55660   -28.15839 1.000 15.23941 ? 206 GLY   A O   1 
ATOM   957  N  N   . VAL   A 1 207 ? -30.04132 6.01870   -30.28325 1.000 15.56468 ? 207 VAL   A N   1 
ATOM   958  C  CA  . VAL   A 1 207 ? -30.81012 4.93022   -30.86857 1.000 13.83139 ? 207 VAL   A CA  1 
ATOM   959  C  C   . VAL   A 1 207 ? -29.92083 4.15359   -31.83006 1.000 14.70865 ? 207 VAL   A C   1 
ATOM   960  O  O   . VAL   A 1 207 ? -28.93023 4.66591   -32.35518 1.000 14.68430 ? 207 VAL   A O   1 
ATOM   961  C  CB  . VAL   A 1 207 ? -32.08057 5.42605   -31.59149 1.000 15.68118 ? 207 VAL   A CB  1 
ATOM   962  C  CG1 . VAL   A 1 207 ? -33.10014 5.93681   -30.58648 1.000 20.91467 ? 207 VAL   A CG1 1 
ATOM   963  C  CG2 . VAL   A 1 207 ? -31.73125 6.50861   -32.59789 1.000 15.14073 ? 207 VAL   A CG2 1 
ATOM   964  N  N   . SER   A 1 208 ? -30.30177 2.90107   -32.06408 1.000 15.29336 ? 208 SER   A N   1 
ATOM   965  C  CA  . SER   A 1 208 ? -29.48185 1.98519   -32.84094 1.000 14.55349 ? 208 SER   A CA  1 
ATOM   966  C  C   . SER   A 1 208 ? -29.55864 2.29714   -34.33437 1.000 12.71844 ? 208 SER   A C   1 
ATOM   967  O  O   . SER   A 1 208 ? -30.42688 3.03858   -34.80506 1.000 12.23268 ? 208 SER   A O   1 
ATOM   968  C  CB  . SER   A 1 208 ? -29.92089 0.54210   -32.59526 1.000 16.87661 ? 208 SER   A CB  1 
ATOM   969  O  OG  . SER   A 1 208 ? -31.22518 0.31851   -33.10702 1.000 15.14435 ? 208 SER   A OG  1 
ATOM   970  N  N   . ASN   A 1 209 ? -28.61601 1.71485   -35.08080 1.000 9.10970  ? 209 ASN   A N   1 
ATOM   971  C  CA  . ASN   A 1 209 ? -28.67278 1.77024   -36.53856 1.000 13.25877 ? 209 ASN   A CA  1 
ATOM   972  C  C   . ASN   A 1 209 ? -29.98417 1.19421   -37.05410 1.000 16.34467 ? 209 ASN   A C   1 
ATOM   973  O  O   . ASN   A 1 209 ? -30.63296 1.77840   -37.92997 1.000 12.79520 ? 209 ASN   A O   1 
ATOM   974  C  CB  . ASN   A 1 209 ? -27.49008 1.00955   -37.14072 1.000 11.11945 ? 209 ASN   A CB  1 
ATOM   975  C  CG  . ASN   A 1 209 ? -26.23320 1.84908   -37.22600 1.000 10.60736 ? 209 ASN   A CG  1 
ATOM   976  O  OD1 . ASN   A 1 209 ? -26.29642 3.07074   -37.34740 1.000 12.73521 ? 209 ASN   A OD1 1 
ATOM   977  N  ND2 . ASN   A 1 209 ? -25.07942 1.19313   -37.17494 1.000 11.07936 ? 209 ASN   A ND2 1 
ATOM   978  N  N   . GLN   A 1 210 ? -30.38533 0.03722   -36.52085 1.000 13.57801 ? 210 GLN   A N   1 
ATOM   979  C  CA  . GLN   A 1 210 ? -31.61822 -0.60071  -36.96853 1.000 15.94207 ? 210 GLN   A CA  1 
ATOM   980  C  C   . GLN   A 1 210 ? -32.82099 0.30491   -36.74016 1.000 17.32087 ? 210 GLN   A C   1 
ATOM   981  O  O   . GLN   A 1 210 ? -33.72133 0.37770   -37.58473 1.000 19.18854 ? 210 GLN   A O   1 
ATOM   982  C  CB  . GLN   A 1 210 ? -31.80593 -1.93646  -36.25026 1.000 13.58626 ? 210 GLN   A CB  1 
ATOM   983  C  CG  . GLN   A 1 210 ? -32.76430 -2.87587  -36.95487 1.000 21.69897 ? 210 GLN   A CG  1 
ATOM   984  C  CD  . GLN   A 1 210 ? -32.34083 -3.15947  -38.38226 1.000 22.86736 ? 210 GLN   A CD  1 
ATOM   985  O  OE1 . GLN   A 1 210 ? -31.27904 -3.73375  -38.62284 1.000 27.71116 ? 210 GLN   A OE1 1 
ATOM   986  N  NE2 . GLN   A 1 210 ? -33.16587 -2.74892  -39.33874 1.000 20.63796 ? 210 GLN   A NE2 1 
ATOM   987  N  N   . PHE   A 1 211 ? -32.84928 1.00979   -35.60609 1.000 15.02515 ? 211 PHE   A N   1 
ATOM   988  C  CA  . PHE   A 1 211 ? -33.93024 1.95616   -35.35229 1.000 18.61126 ? 211 PHE   A CA  1 
ATOM   989  C  C   . PHE   A 1 211 ? -33.93959 3.07073   -36.39049 1.000 20.01511 ? 211 PHE   A C   1 
ATOM   990  O  O   . PHE   A 1 211 ? -35.00053 3.43511   -36.91104 1.000 16.60722 ? 211 PHE   A O   1 
ATOM   991  C  CB  . PHE   A 1 211 ? -33.80157 2.53726   -33.94374 1.000 14.73670 ? 211 PHE   A CB  1 
ATOM   992  C  CG  . PHE   A 1 211 ? -34.85999 3.55040   -33.60648 1.000 21.29849 ? 211 PHE   A CG  1 
ATOM   993  C  CD1 . PHE   A 1 211 ? -34.66712 4.89724   -33.87939 1.000 15.28793 ? 211 PHE   A CD1 1 
ATOM   994  C  CD2 . PHE   A 1 211 ? -36.04834 3.15532   -33.01684 1.000 19.31869 ? 211 PHE   A CD2 1 
ATOM   995  C  CE1 . PHE   A 1 211 ? -35.63765 5.82756   -33.57290 1.000 22.36920 ? 211 PHE   A CE1 1 
ATOM   996  C  CE2 . PHE   A 1 211 ? -37.02324 4.08141   -32.70644 1.000 23.31853 ? 211 PHE   A CE2 1 
ATOM   997  C  CZ  . PHE   A 1 211 ? -36.81768 5.41989   -32.98458 1.000 23.69999 ? 211 PHE   A CZ  1 
ATOM   998  N  N   . LEU   A 1 212 ? -32.76667 3.63180   -36.69652 1.000 17.01925 ? 212 LEU   A N   1 
ATOM   999  C  CA  . LEU   A 1 212 ? -32.69316 4.69648   -37.69201 1.000 16.76634 ? 212 LEU   A CA  1 
ATOM   1000 C  C   . LEU   A 1 212 ? -33.10114 4.19021   -39.06944 1.000 16.46736 ? 212 LEU   A C   1 
ATOM   1001 O  O   . LEU   A 1 212 ? -33.72298 4.92273   -39.84786 1.000 17.52795 ? 212 LEU   A O   1 
ATOM   1002 C  CB  . LEU   A 1 212 ? -31.28188 5.28285   -37.72834 1.000 13.72754 ? 212 LEU   A CB  1 
ATOM   1003 C  CG  . LEU   A 1 212 ? -30.77915 5.94654   -36.44481 1.000 13.67868 ? 212 LEU   A CG  1 
ATOM   1004 C  CD1 . LEU   A 1 212 ? -29.29634 6.25795   -36.55424 1.000 11.64008 ? 212 LEU   A CD1 1 
ATOM   1005 C  CD2 . LEU   A 1 212 ? -31.57003 7.20989   -36.14433 1.000 11.43443 ? 212 LEU   A CD2 1 
ATOM   1006 N  N   . ILE   A 1 213 ? -32.76119 2.93981   -39.38551 1.000 15.85303 ? 213 ILE   A N   1 
ATOM   1007 C  CA  . ILE   A 1 213 ? -33.19847 2.34166   -40.64262 1.000 15.67951 ? 213 ILE   A CA  1 
ATOM   1008 C  C   . ILE   A 1 213 ? -34.71048 2.15962   -40.64563 1.000 23.90360 ? 213 ILE   A C   1 
ATOM   1009 O  O   . ILE   A 1 213 ? -35.40346 2.58527   -41.57742 1.000 16.15598 ? 213 ILE   A O   1 
ATOM   1010 C  CB  . ILE   A 1 213 ? -32.47750 1.00255   -40.87749 1.000 18.40422 ? 213 ILE   A CB  1 
ATOM   1011 C  CG1 . ILE   A 1 213 ? -30.97982 1.22157   -41.08997 1.000 15.39941 ? 213 ILE   A CG1 1 
ATOM   1012 C  CG2 . ILE   A 1 213 ? -33.09357 0.26622   -42.05552 1.000 18.39608 ? 213 ILE   A CG2 1 
ATOM   1013 C  CD1 . ILE   A 1 213 ? -30.18123 -0.06136  -41.07886 1.000 16.86929 ? 213 ILE   A CD1 1 
ATOM   1014 N  N   . ASN   A 1 214 ? -35.24373 1.53337   -39.59261 1.000 21.45765 ? 214 ASN   A N   1 
ATOM   1015 C  CA  . ASN   A 1 214 ? -36.65387 1.15801   -39.57473 1.000 26.52843 ? 214 ASN   A CA  1 
ATOM   1016 C  C   . ASN   A 1 214 ? -37.57493 2.37164   -39.53452 1.000 21.76499 ? 214 ASN   A C   1 
ATOM   1017 O  O   . ASN   A 1 214 ? -38.72094 2.28774   -39.99007 1.000 31.29242 ? 214 ASN   A O   1 
ATOM   1018 C  CB  . ASN   A 1 214 ? -36.93566 0.23984   -38.38380 1.000 19.00242 ? 214 ASN   A CB  1 
ATOM   1019 C  CG  . ASN   A 1 214 ? -36.29625 -1.12986  -38.53631 1.000 22.10464 ? 214 ASN   A CG  1 
ATOM   1020 O  OD1 . ASN   A 1 214 ? -35.88553 -1.51823  -39.63012 1.000 30.08382 ? 214 ASN   A OD1 1 
ATOM   1021 N  ND2 . ASN   A 1 214 ? -36.21654 -1.87209  -37.43690 1.000 28.26088 ? 214 ASN   A ND2 1 
ATOM   1022 N  N   . THR   A 1 215 ? -37.10651 3.49776   -38.99869 1.000 21.60024 ? 215 THR   A N   1 
ATOM   1023 C  CA  . THR   A 1 215 ? -37.91066 4.70979   -38.91581 1.000 21.67765 ? 215 THR   A CA  1 
ATOM   1024 C  C   . THR   A 1 215 ? -37.66394 5.66049   -40.07987 1.000 22.98504 ? 215 THR   A C   1 
ATOM   1025 O  O   . THR   A 1 215 ? -38.15141 6.79565   -40.05073 1.000 20.38626 ? 215 THR   A O   1 
ATOM   1026 C  CB  . THR   A 1 215 ? -37.65465 5.43098   -37.58993 1.000 26.64000 ? 215 THR   A CB  1 
ATOM   1027 O  OG1 . THR   A 1 215 ? -36.27625 5.81498   -37.50359 1.000 20.08555 ? 215 THR   A OG1 1 
ATOM   1028 C  CG2 . THR   A 1 215 ? -38.00018 4.52294   -36.42050 1.000 22.05883 ? 215 THR   A CG2 1 
ATOM   1029 N  N   . ASN   A 1 216 ? -36.92304 5.22066   -41.09935 1.000 21.92240 ? 216 ASN   A N   1 
ATOM   1030 C  CA  . ASN   A 1 216 ? -36.66422 6.02349   -42.29584 1.000 23.50198 ? 216 ASN   A CA  1 
ATOM   1031 C  C   . ASN   A 1 216 ? -36.07106 7.38068   -41.92842 1.000 19.54444 ? 216 ASN   A C   1 
ATOM   1032 O  O   . ASN   A 1 216 ? -36.46942 8.42382   -42.45170 1.000 24.29373 ? 216 ASN   A O   1 
ATOM   1033 C  CB  . ASN   A 1 216 ? -37.93605 6.18503   -43.12988 1.000 20.52014 ? 216 ASN   A CB  1 
ATOM   1034 C  CG  . ASN   A 1 216 ? -38.62246 4.85991   -43.40752 1.000 29.72294 ? 216 ASN   A CG  1 
ATOM   1035 O  OD1 . ASN   A 1 216 ? -37.98604 3.88954   -43.82088 1.000 29.80790 ? 216 ASN   A OD1 1 
ATOM   1036 N  ND2 . ASN   A 1 216 ? -39.92800 4.81169   -43.17311 1.000 29.91403 ? 216 ASN   A ND2 1 
ATOM   1037 N  N   . SER   A 1 217 ? -35.11338 7.36107   -41.00525 1.000 18.98588 ? 217 SER   A N   1 
ATOM   1038 C  CA  . SER   A 1 217 ? -34.46540 8.58259   -40.55893 1.000 18.14561 ? 217 SER   A CA  1 
ATOM   1039 C  C   . SER   A 1 217 ? -33.68130 9.21964   -41.70123 1.000 19.37285 ? 217 SER   A C   1 
ATOM   1040 O  O   . SER   A 1 217 ? -33.33469 8.57199   -42.69346 1.000 20.02041 ? 217 SER   A O   1 
ATOM   1041 C  CB  . SER   A 1 217 ? -33.53008 8.29074   -39.38680 1.000 15.74928 ? 217 SER   A CB  1 
ATOM   1042 O  OG  . SER   A 1 217 ? -32.51321 7.38150   -39.77373 1.000 18.19089 ? 217 SER   A OG  1 
ATOM   1043 N  N   . GLU   A 1 218 ? -33.40972 10.51842  -41.55266 1.000 19.11053 ? 218 GLU   A N   1 
ATOM   1044 C  CA  . GLU   A 1 218 ? -32.55249 11.20204  -42.51447 1.000 20.69478 ? 218 GLU   A CA  1 
ATOM   1045 C  C   . GLU   A 1 218 ? -31.15154 10.60568  -42.51049 1.000 17.31926 ? 218 GLU   A C   1 
ATOM   1046 O  O   . GLU   A 1 218 ? -30.51078 10.49707  -43.56269 1.000 14.96081 ? 218 GLU   A O   1 
ATOM   1047 C  CB  . GLU   A 1 218 ? -32.50232 12.69873  -42.20546 1.000 26.40198 ? 218 GLU   A CB  1 
ATOM   1048 C  CG  . GLU   A 1 218 ? -33.80973 13.42810  -42.45044 1.000 36.74234 ? 218 GLU   A CG  1 
ATOM   1049 C  CD  . GLU   A 1 218 ? -34.38875 13.14019  -43.82305 1.000 40.65157 ? 218 GLU   A CD  1 
ATOM   1050 O  OE1 . GLU   A 1 218 ? -33.77656 13.55156  -44.82893 1.000 41.79486 ? 218 GLU   A OE1 1 
ATOM   1051 O  OE2 . GLU   A 1 218 ? -35.45913 12.50406  -43.89989 1.000 50.43686 ? 218 GLU   A OE2 1 
ATOM   1052 N  N   . LEU   A 1 219 ? -30.66789 10.20042  -41.33306 1.000 19.48272 ? 219 LEU   A N   1 
ATOM   1053 C  CA  . LEU   A 1 219 ? -29.34681 9.58756   -41.23018 1.000 14.38617 ? 219 LEU   A CA  1 
ATOM   1054 C  C   . LEU   A 1 219 ? -29.25729 8.31966   -42.07081 1.000 15.67983 ? 219 LEU   A C   1 
ATOM   1055 O  O   . LEU   A 1 219 ? -28.32602 8.15372   -42.86770 1.000 12.41657 ? 219 LEU   A O   1 
ATOM   1056 C  CB  . LEU   A 1 219 ? -29.02618 9.28704   -39.76583 1.000 15.79790 ? 219 LEU   A CB  1 
ATOM   1057 C  CG  . LEU   A 1 219 ? -28.40672 10.42130  -38.95196 1.000 22.36551 ? 219 LEU   A CG  1 
ATOM   1058 C  CD1 . LEU   A 1 219 ? -28.39135 10.07099  -37.47367 1.000 20.00463 ? 219 LEU   A CD1 1 
ATOM   1059 C  CD2 . LEU   A 1 219 ? -27.00152 10.69319  -39.45411 1.000 18.32809 ? 219 LEU   A CD2 1 
ATOM   1060 N  N   . ALA   A 1 220 ? -30.22016 7.40848   -41.90293 1.000 11.62696 ? 220 ALA   A N   1 
ATOM   1061 C  CA  . ALA   A 1 220 ? -30.22372 6.18264   -42.69474 1.000 16.22122 ? 220 ALA   A CA  1 
ATOM   1062 C  C   . ALA   A 1 220 ? -30.43001 6.47264   -44.17471 1.000 15.96684 ? 220 ALA   A C   1 
ATOM   1063 O  O   . ALA   A 1 220 ? -29.89038 5.75782   -45.02705 1.000 12.19573 ? 220 ALA   A O   1 
ATOM   1064 C  CB  . ALA   A 1 220 ? -31.30327 5.22803   -42.18500 1.000 13.46118 ? 220 ALA   A CB  1 
ATOM   1065 N  N   . LEU   A 1 221 ? -31.20604 7.50984   -44.49574 1.000 13.46067 ? 221 LEU   A N   1 
ATOM   1066 C  CA  . LEU   A 1 221 ? -31.37095 7.91557   -45.88697 1.000 14.74226 ? 221 LEU   A CA  1 
ATOM   1067 C  C   . LEU   A 1 221 ? -30.06001 8.43278   -46.46229 1.000 17.25257 ? 221 LEU   A C   1 
ATOM   1068 O  O   . LEU   A 1 221 ? -29.71155 8.13251   -47.61070 1.000 16.21026 ? 221 LEU   A O   1 
ATOM   1069 C  CB  . LEU   A 1 221 ? -32.45838 8.98429   -45.98431 1.000 16.32584 ? 221 LEU   A CB  1 
ATOM   1070 C  CG  . LEU   A 1 221 ? -33.01595 9.35236   -47.35733 1.000 25.57029 ? 221 LEU   A CG  1 
ATOM   1071 C  CD1 . LEU   A 1 221 ? -33.81426 8.19996   -47.93803 1.000 25.30652 ? 221 LEU   A CD1 1 
ATOM   1072 C  CD2 . LEU   A 1 221 ? -33.87904 10.59163  -47.23544 1.000 32.16660 ? 221 LEU   A CD2 1 
ATOM   1073 N  N   . MET   A 1 222 ? -29.31977 9.21305   -45.67275 1.000 11.82681 ? 222 MET   A N   1 
ATOM   1074 C  CA  . MET   A 1 222 ? -28.04151 9.74177   -46.13302 1.000 12.48506 ? 222 MET   A CA  1 
ATOM   1075 C  C   . MET   A 1 222 ? -27.04169 8.62340   -46.39449 1.000 14.27622 ? 222 MET   A C   1 
ATOM   1076 O  O   . MET   A 1 222 ? -26.34035 8.63316   -47.41242 1.000 11.63810 ? 222 MET   A O   1 
ATOM   1077 C  CB  . MET   A 1 222 ? -27.48281 10.72253  -45.10134 1.000 11.84422 ? 222 MET   A CB  1 
ATOM   1078 C  CG  . MET   A 1 222 ? -26.19580 11.41377  -45.52307 1.000 15.18770 ? 222 MET   A CG  1 
ATOM   1079 S  SD  . MET   A 1 222 ? -26.45596 12.69888  -46.76064 1.000 20.97678 ? 222 MET   A SD  1 
ATOM   1080 C  CE  . MET   A 1 222 ? -27.24940 13.96255  -45.76852 1.000 16.86606 ? 222 MET   A CE  1 
ATOM   1081 N  N   . TYR   A 1 223 ? -26.97327 7.64109   -45.49702 1.000 11.91344 ? 223 TYR   A N   1 
ATOM   1082 C  CA  . TYR   A 1 223 ? -25.90923 6.64661   -45.51736 1.000 12.65322 ? 223 TYR   A CA  1 
ATOM   1083 C  C   . TYR   A 1 223 ? -26.36666 5.28153   -46.01230 1.000 11.64294 ? 223 TYR   A C   1 
ATOM   1084 O  O   . TYR   A 1 223 ? -25.62423 4.30351   -45.86966 1.000 11.69241 ? 223 TYR   A O   1 
ATOM   1085 C  CB  . TYR   A 1 223 ? -25.27983 6.54218   -44.12868 1.000 10.59206 ? 223 TYR   A CB  1 
ATOM   1086 C  CG  . TYR   A 1 223 ? -24.46226 7.76709   -43.81512 1.000 15.16479 ? 223 TYR   A CG  1 
ATOM   1087 C  CD1 . TYR   A 1 223 ? -23.34446 8.07648   -44.57603 1.000 10.30827 ? 223 TYR   A CD1 1 
ATOM   1088 C  CD2 . TYR   A 1 223 ? -24.82233 8.63345   -42.79024 1.000 11.78193 ? 223 TYR   A CD2 1 
ATOM   1089 C  CE1 . TYR   A 1 223 ? -22.59465 9.19862   -44.31699 1.000 10.82108 ? 223 TYR   A CE1 1 
ATOM   1090 C  CE2 . TYR   A 1 223 ? -24.07373 9.76412   -42.52037 1.000 14.19434 ? 223 TYR   A CE2 1 
ATOM   1091 C  CZ  . TYR   A 1 223 ? -22.96030 10.03996  -43.28805 1.000 13.77644 ? 223 TYR   A CZ  1 
ATOM   1092 O  OH  . TYR   A 1 223 ? -22.20742 11.16174  -43.03091 1.000 14.17714 ? 223 TYR   A OH  1 
ATOM   1093 N  N   . ASN   A 1 224 ? -27.56323 5.19643   -46.59657 1.000 11.64242 ? 224 ASN   A N   1 
ATOM   1094 C  CA  . ASN   A 1 224 ? -28.00994 4.00715   -47.32453 1.000 13.37169 ? 224 ASN   A CA  1 
ATOM   1095 C  C   . ASN   A 1 224 ? -27.97358 2.75819   -46.44532 1.000 13.02921 ? 224 ASN   A C   1 
ATOM   1096 O  O   . ASN   A 1 224 ? -27.59275 1.67274   -46.89054 1.000 9.20130  ? 224 ASN   A O   1 
ATOM   1097 C  CB  . ASN   A 1 224 ? -27.18448 3.80991   -48.59822 1.000 13.18904 ? 224 ASN   A CB  1 
ATOM   1098 C  CG  . ASN   A 1 224 ? -27.26065 5.00717   -49.53102 1.000 11.90855 ? 224 ASN   A CG  1 
ATOM   1099 O  OD1 . ASN   A 1 224 ? -28.34710 5.43639   -49.92000 1.000 15.31099 ? 224 ASN   A OD1 1 
ATOM   1100 N  ND2 . ASN   A 1 224 ? -26.10454 5.56150   -49.88140 1.000 11.96877 ? 224 ASN   A ND2 1 
ATOM   1101 N  N   . ASP   A 1 225 ? -28.35863 2.92611   -45.17895 1.000 12.77001 ? 225 ASP   A N   1 
ATOM   1102 C  CA  . ASP   A 1 225 ? -28.56460 1.86245   -44.19818 1.000 12.59659 ? 225 ASP   A CA  1 
ATOM   1103 C  C   . ASP   A 1 225 ? -27.28310 1.14161   -43.79847 1.000 14.78398 ? 225 ASP   A C   1 
ATOM   1104 O  O   . ASP   A 1 225 ? -27.35315 0.11776   -43.10709 1.000 13.62275 ? 225 ASP   A O   1 
ATOM   1105 C  CB  . ASP   A 1 225 ? -29.58421 0.82701   -44.69084 1.000 10.02696 ? 225 ASP   A CB  1 
ATOM   1106 C  CG  . ASP   A 1 225 ? -30.94637 1.43220   -44.96729 1.000 15.89523 ? 225 ASP   A CG  1 
ATOM   1107 O  OD1 . ASP   A 1 225 ? -31.21953 2.54688   -44.47201 1.000 13.26819 ? 225 ASP   A OD1 1 
ATOM   1108 O  OD2 . ASP   A 1 225 ? -31.74486 0.78850   -45.68134 1.000 12.96188 ? 225 ASP   A OD2 1 
ATOM   1109 N  N   . SER   A 1 226 ? -26.11603 1.64255   -44.19265 1.000 16.29556 ? 226 SER   A N   1 
ATOM   1110 C  CA  . SER   A 1 226 ? -24.84882 0.95742   -43.96235 1.000 13.73280 ? 226 SER   A CA  1 
ATOM   1111 C  C   . SER   A 1 226 ? -23.99948 1.76654   -42.99121 1.000 9.96971  ? 226 SER   A C   1 
ATOM   1112 O  O   . SER   A 1 226 ? -23.58611 2.88638   -43.31307 1.000 10.43489 ? 226 SER   A O   1 
ATOM   1113 C  CB  . SER   A 1 226 ? -24.10149 0.74320   -45.27854 1.000 12.30526 ? 226 SER   A CB  1 
ATOM   1114 O  OG  . SER   A 1 226 ? -24.93625 0.11783   -46.23954 1.000 24.62993 ? 226 SER   A OG  1 
ATOM   1115 N  N   . SER   A 1 227 ? -23.73015 1.18775   -41.81953 1.000 11.53131 ? 227 SER   A N   1 
ATOM   1116 C  CA  . SER   A 1 227 ? -22.95187 1.83278   -40.75888 1.000 9.63761  ? 227 SER   A CA  1 
ATOM   1117 C  C   . SER   A 1 227 ? -23.37829 3.28683   -40.58310 1.000 11.00771 ? 227 SER   A C   1 
ATOM   1118 O  O   . SER   A 1 227 ? -22.56180 4.21159   -40.58003 1.000 8.79401  ? 227 SER   A O   1 
ATOM   1119 C  CB  . SER   A 1 227 ? -21.45229 1.72961   -41.03558 1.000 10.98674 ? 227 SER   A CB  1 
ATOM   1120 O  OG  . SER   A 1 227 ? -21.01974 0.37904   -41.05568 1.000 11.97773 ? 227 SER   A OG  1 
ATOM   1121 N  N   . VAL   A 1 228 ? -24.69332 3.47242   -40.44226 1.000 9.07598  ? 228 VAL   A N   1 
ATOM   1122 C  CA  . VAL   A 1 228 ? -25.29130 4.80670   -40.47618 1.000 10.27915 ? 228 VAL   A CA  1 
ATOM   1123 C  C   . VAL   A 1 228 ? -24.67040 5.70111   -39.41168 1.000 9.82262  ? 228 VAL   A C   1 
ATOM   1124 O  O   . VAL   A 1 228 ? -24.15423 6.78601   -39.70496 1.000 11.77201 ? 228 VAL   A O   1 
ATOM   1125 C  CB  . VAL   A 1 228 ? -26.81647 4.70915   -40.30383 1.000 10.97302 ? 228 VAL   A CB  1 
ATOM   1126 C  CG1 . VAL   A 1 228 ? -27.41506 6.08497   -40.08718 1.000 10.89994 ? 228 VAL   A CG1 1 
ATOM   1127 C  CG2 . VAL   A 1 228 ? -27.43459 4.03502   -41.51192 1.000 13.52798 ? 228 VAL   A CG2 1 
ATOM   1128 N  N   . LEU   A 1 229 ? -24.71916 5.25514   -38.15681 1.000 10.51500 ? 229 LEU   A N   1 
ATOM   1129 C  CA  . LEU   A 1 229 ? -24.15524 6.03610   -37.06166 1.000 10.50887 ? 229 LEU   A CA  1 
ATOM   1130 C  C   . LEU   A 1 229 ? -22.66109 6.25472   -37.25111 1.000 9.06079  ? 229 LEU   A C   1 
ATOM   1131 O  O   . LEU   A 1 229 ? -22.16026 7.37688   -37.11198 1.000 7.83573  ? 229 LEU   A O   1 
ATOM   1132 C  CB  . LEU   A 1 229 ? -24.42166 5.32793   -35.73529 1.000 12.96087 ? 229 LEU   A CB  1 
ATOM   1133 C  CG  . LEU   A 1 229 ? -25.86300 5.34670   -35.23857 1.000 16.96203 ? 229 LEU   A CG  1 
ATOM   1134 C  CD1 . LEU   A 1 229 ? -26.09714 4.22874   -34.24062 1.000 13.36476 ? 229 LEU   A CD1 1 
ATOM   1135 C  CD2 . LEU   A 1 229 ? -26.14323 6.68401   -34.61493 1.000 13.94443 ? 229 LEU   A CD2 1 
ATOM   1136 N  N   . GLU   A 1 230 ? -21.93524 5.18556   -37.57944 1.000 9.77322  ? 230 GLU   A N   1 
ATOM   1137 C  CA  . GLU   A 1 230 ? -20.47828 5.24316   -37.59365 1.000 7.94495  ? 230 GLU   A CA  1 
ATOM   1138 C  C   . GLU   A 1 230 ? -19.96610 6.16126   -38.69782 1.000 10.24829 ? 230 GLU   A C   1 
ATOM   1139 O  O   . GLU   A 1 230 ? -18.98054 6.88308   -38.50233 1.000 11.91159 ? 230 GLU   A O   1 
ATOM   1140 C  CB  . GLU   A 1 230 ? -19.91110 3.83039   -37.73586 1.000 7.00924  ? 230 GLU   A CB  1 
ATOM   1141 C  CG  . GLU   A 1 230 ? -20.15591 2.93728   -36.51406 1.000 8.90453  ? 230 GLU   A CG  1 
ATOM   1142 C  CD  . GLU   A 1 230 ? -21.59242 2.44253   -36.40720 1.000 14.45172 ? 230 GLU   A CD  1 
ATOM   1143 O  OE1 . GLU   A 1 230 ? -22.29484 2.41703   -37.43991 1.000 8.50851  ? 230 GLU   A OE1 1 
ATOM   1144 O  OE2 . GLU   A 1 230 ? -22.02079 2.08773   -35.28757 1.000 12.00285 ? 230 GLU   A OE2 1 
ATOM   1145 N  N   . ASN   A 1 231 ? -20.62070 6.15277   -39.86261 1.000 9.41798  ? 231 ASN   A N   1 
ATOM   1146 C  CA  . ASN   A 1 231 ? -20.29295 7.13353   -40.89300 1.000 10.46055 ? 231 ASN   A CA  1 
ATOM   1147 C  C   . ASN   A 1 231 ? -20.57732 8.54920   -40.40863 1.000 10.38679 ? 231 ASN   A C   1 
ATOM   1148 O  O   . ASN   A 1 231 ? -19.81642 9.47911   -40.70158 1.000 9.90673  ? 231 ASN   A O   1 
ATOM   1149 C  CB  . ASN   A 1 231 ? -21.07624 6.84412   -42.17462 1.000 12.47501 ? 231 ASN   A CB  1 
ATOM   1150 C  CG  . ASN   A 1 231 ? -20.38192 5.83815   -43.07256 1.000 15.35874 ? 231 ASN   A CG  1 
ATOM   1151 O  OD1 . ASN   A 1 231 ? -19.31035 6.10968   -43.61576 1.000 13.19234 ? 231 ASN   A OD1 1 
ATOM   1152 N  ND2 . ASN   A 1 231 ? -20.99465 4.67122   -43.23999 1.000 10.49955 ? 231 ASN   A ND2 1 
ATOM   1153 N  N   . HIS   A 1 232 ? -21.66924 8.73152   -39.66239 1.000 11.81813 ? 232 HIS   A N   1 
ATOM   1154 C  CA  . HIS   A 1 232 ? -22.01673 10.06129  -39.17199 1.000 12.95266 ? 232 HIS   A CA  1 
ATOM   1155 C  C   . HIS   A 1 232 ? -21.01151 10.54630  -38.13605 1.000 10.88191 ? 232 HIS   A C   1 
ATOM   1156 O  O   . HIS   A 1 232 ? -20.59029 11.70877  -38.16571 1.000 12.31266 ? 232 HIS   A O   1 
ATOM   1157 C  CB  . HIS   A 1 232 ? -23.42744 10.05971  -38.58558 1.000 12.96085 ? 232 HIS   A CB  1 
ATOM   1158 C  CG  . HIS   A 1 232 ? -23.89613 11.41234  -38.14772 1.000 13.32692 ? 232 HIS   A CG  1 
ATOM   1159 N  ND1 . HIS   A 1 232 ? -24.02272 12.47341  -39.01815 1.000 13.44432 ? 232 HIS   A ND1 1 
ATOM   1160 C  CD2 . HIS   A 1 232 ? -24.26106 11.87918  -36.93018 1.000 12.71294 ? 232 HIS   A CD2 1 
ATOM   1161 C  CE1 . HIS   A 1 232 ? -24.45038 13.53413  -38.35683 1.000 15.33797 ? 232 HIS   A CE1 1 
ATOM   1162 N  NE2 . HIS   A 1 232 ? -24.60264 13.20039  -37.08797 1.000 13.71980 ? 232 HIS   A NE2 1 
ATOM   1163 N  N   . HIS   A 1 233 ? -20.63041 9.67140   -37.19969 1.000 11.12199 ? 233 HIS   A N   1 
ATOM   1164 C  CA  . HIS   A 1 233 ? -19.60892 10.02092  -36.21634 1.000 11.12502 ? 233 HIS   A CA  1 
ATOM   1165 C  C   . HIS   A 1 233 ? -18.35110 10.54083  -36.90137 1.000 10.98701 ? 233 HIS   A C   1 
ATOM   1166 O  O   . HIS   A 1 233 ? -17.78360 11.56440  -36.50218 1.000 10.80568 ? 233 HIS   A O   1 
ATOM   1167 C  CB  . HIS   A 1 233 ? -19.27125 8.80515   -35.34823 1.000 10.76067 ? 233 HIS   A CB  1 
ATOM   1168 C  CG  . HIS   A 1 233 ? -20.45513 8.18404   -34.67212 1.000 13.90708 ? 233 HIS   A CG  1 
ATOM   1169 N  ND1 . HIS   A 1 233 ? -21.46341 8.92859   -34.09834 1.000 11.58207 ? 233 HIS   A ND1 1 
ATOM   1170 C  CD2 . HIS   A 1 233 ? -20.78293 6.88577   -34.46613 1.000 8.14457  ? 233 HIS   A CD2 1 
ATOM   1171 C  CE1 . HIS   A 1 233 ? -22.36356 8.11609   -33.57343 1.000 10.75803 ? 233 HIS   A CE1 1 
ATOM   1172 N  NE2 . HIS   A 1 233 ? -21.97364 6.87132   -33.78169 1.000 12.08227 ? 233 HIS   A NE2 1 
ATOM   1173 N  N   . LEU   A 1 234 ? -17.90737 9.84050   -37.94676 1.000 9.17957  ? 234 LEU   A N   1 
ATOM   1174 C  CA  . LEU   A 1 234 ? -16.71284 10.25157  -38.67611 1.000 9.97597  ? 234 LEU   A CA  1 
ATOM   1175 C  C   . LEU   A 1 234 ? -16.90993 11.60624  -39.34255 1.000 11.13259 ? 234 LEU   A C   1 
ATOM   1176 O  O   . LEU   A 1 234 ? -16.06296 12.49871  -39.22067 1.000 10.15704 ? 234 LEU   A O   1 
ATOM   1177 C  CB  . LEU   A 1 234 ? -16.35038 9.19110   -39.71421 1.000 7.45932  ? 234 LEU   A CB  1 
ATOM   1178 C  CG  . LEU   A 1 234 ? -15.60454 7.96900   -39.18649 1.000 10.31665 ? 234 LEU   A CG  1 
ATOM   1179 C  CD1 . LEU   A 1 234 ? -15.67177 6.81597   -40.17550 1.000 7.37354  ? 234 LEU   A CD1 1 
ATOM   1180 C  CD2 . LEU   A 1 234 ? -14.16372 8.34364   -38.89300 1.000 8.16729  ? 234 LEU   A CD2 1 
ATOM   1181 N  N   . ALA   A 1 235 ? -18.02556 11.77370  -40.05950 1.000 10.24717 ? 235 ALA   A N   1 
ATOM   1182 C  CA  . ALA   A 1 235 ? -18.27534 13.02554  -40.76724 1.000 12.42926 ? 235 ALA   A CA  1 
ATOM   1183 C  C   . ALA   A 1 235 ? -18.29722 14.20813  -39.80873 1.000 11.46249 ? 235 ALA   A C   1 
ATOM   1184 O  O   . ALA   A 1 235 ? -17.70203 15.25411  -40.09021 1.000 15.26390 ? 235 ALA   A O   1 
ATOM   1185 C  CB  . ALA   A 1 235 ? -19.58995 12.93891  -41.54231 1.000 11.60883 ? 235 ALA   A CB  1 
ATOM   1186 N  N   . VAL   A 1 236 ? -18.96638 14.05619  -38.66448 1.000 9.38161  ? 236 VAL   A N   1 
ATOM   1187 C  CA  . VAL   A 1 236 ? -19.01952 15.13554  -37.68260 1.000 9.55464  ? 236 VAL   A CA  1 
ATOM   1188 C  C   . VAL   A 1 236 ? -17.63702 15.39074  -37.09403 1.000 10.96264 ? 236 VAL   A C   1 
ATOM   1189 O  O   . VAL   A 1 236 ? -17.19195 16.54022  -36.99003 1.000 10.50688 ? 236 VAL   A O   1 
ATOM   1190 C  CB  . VAL   A 1 236 ? -20.04786 14.81150  -36.58408 1.000 13.50490 ? 236 VAL   A CB  1 
ATOM   1191 C  CG1 . VAL   A 1 236 ? -19.91037 15.78556  -35.42667 1.000 8.25133  ? 236 VAL   A CG1 1 
ATOM   1192 C  CG2 . VAL   A 1 236 ? -21.45669 14.85510  -37.14900 1.000 13.00180 ? 236 VAL   A CG2 1 
ATOM   1193 N  N   . GLY   A 1 237 ? -16.93790 14.32175  -36.70282 1.000 12.45742 ? 237 GLY   A N   1 
ATOM   1194 C  CA  . GLY   A 1 237 ? -15.63508 14.48569  -36.07606 1.000 8.84024  ? 237 GLY   A CA  1 
ATOM   1195 C  C   . GLY   A 1 237 ? -14.62782 15.17753  -36.97440 1.000 10.54426 ? 237 GLY   A C   1 
ATOM   1196 O  O   . GLY   A 1 237 ? -13.86052 16.03051  -36.52079 1.000 12.03100 ? 237 GLY   A O   1 
ATOM   1197 N  N   . PHE   A 1 238 ? -14.61354 14.82046  -38.26073 1.000 7.78291  ? 238 PHE   A N   1 
ATOM   1198 C  CA  . PHE   A 1 238 ? -13.72676 15.50221  -39.19819 1.000 13.58589 ? 238 PHE   A CA  1 
ATOM   1199 C  C   . PHE   A 1 238 ? -14.21006 16.91888  -39.48697 1.000 12.73636 ? 238 PHE   A C   1 
ATOM   1200 O  O   . PHE   A 1 238 ? -13.40041 17.84955  -39.56929 1.000 14.36721 ? 238 PHE   A O   1 
ATOM   1201 C  CB  . PHE   A 1 238 ? -13.61246 14.70888  -40.50042 1.000 14.20475 ? 238 PHE   A CB  1 
ATOM   1202 C  CG  . PHE   A 1 238 ? -12.75999 13.47533  -40.39569 1.000 14.74173 ? 238 PHE   A CG  1 
ATOM   1203 C  CD1 . PHE   A 1 238 ? -11.41661 13.56720  -40.06467 1.000 16.81134 ? 238 PHE   A CD1 1 
ATOM   1204 C  CD2 . PHE   A 1 238 ? -13.29732 12.22518  -40.65485 1.000 13.92171 ? 238 PHE   A CD2 1 
ATOM   1205 C  CE1 . PHE   A 1 238 ? -10.62903 12.43180  -39.97812 1.000 13.49953 ? 238 PHE   A CE1 1 
ATOM   1206 C  CE2 . PHE   A 1 238 ? -12.51639 11.08703  -40.57265 1.000 15.44247 ? 238 PHE   A CE2 1 
ATOM   1207 C  CZ  . PHE   A 1 238 ? -11.18000 11.19044  -40.23313 1.000 13.30095 ? 238 PHE   A CZ  1 
ATOM   1208 N  N   . LYS   A 1 239 ? -15.52583 17.09929  -39.64612 1.000 9.61013  ? 239 LYS   A N   1 
ATOM   1209 C  CA  . LYS   A 1 239 ? -16.06999 18.41205  -39.98960 1.000 16.45296 ? 239 LYS   A CA  1 
ATOM   1210 C  C   . LYS   A 1 239 ? -15.72972 19.45463  -38.93218 1.000 19.98371 ? 239 LYS   A C   1 
ATOM   1211 O  O   . LYS   A 1 239 ? -15.42948 20.60866  -39.26189 1.000 15.80003 ? 239 LYS   A O   1 
ATOM   1212 C  CB  . LYS   A 1 239 ? -17.58564 18.31793  -40.17434 1.000 15.17212 ? 239 LYS   A CB  1 
ATOM   1213 C  CG  . LYS   A 1 239 ? -18.29452 19.65090  -40.36949 1.000 27.38831 ? 239 LYS   A CG  1 
ATOM   1214 C  CD  . LYS   A 1 239 ? -17.92244 20.30237  -41.69089 1.000 34.10438 ? 239 LYS   A CD  1 
ATOM   1215 C  CE  . LYS   A 1 239 ? -18.91645 21.38894  -42.07092 1.000 36.94596 ? 239 LYS   A CE  1 
ATOM   1216 N  NZ  . LYS   A 1 239 ? -18.52733 22.07925  -43.33092 1.000 40.79946 ? 239 LYS   A NZ  1 
ATOM   1217 N  N   . LEU   A 1 240 ? -15.76560 19.06682  -37.65465 1.000 15.68138 ? 240 LEU   A N   1 
ATOM   1218 C  CA  . LEU   A 1 240 ? -15.49211 20.01408  -36.58051 1.000 15.82168 ? 240 LEU   A CA  1 
ATOM   1219 C  C   . LEU   A 1 240 ? -14.05222 20.51021  -36.59448 1.000 17.70921 ? 240 LEU   A C   1 
ATOM   1220 O  O   . LEU   A 1 240 ? -13.76120 21.53883  -35.97493 1.000 17.55890 ? 240 LEU   A O   1 
ATOM   1221 C  CB  . LEU   A 1 240 ? -15.82208 19.38374  -35.22583 1.000 12.80421 ? 240 LEU   A CB  1 
ATOM   1222 C  CG  . LEU   A 1 240 ? -17.30695 19.09730  -34.98527 1.000 13.55238 ? 240 LEU   A CG  1 
ATOM   1223 C  CD1 . LEU   A 1 240 ? -17.51910 18.32922  -33.68981 1.000 10.37670 ? 240 LEU   A CD1 1 
ATOM   1224 C  CD2 . LEU   A 1 240 ? -18.10736 20.39076  -34.98053 1.000 14.15853 ? 240 LEU   A CD2 1 
ATOM   1225 N  N   . LEU   A 1 241 ? -13.15038 19.81071  -37.28948 1.000 15.35885 ? 241 LEU   A N   1 
ATOM   1226 C  CA  . LEU   A 1 241 ? -11.78677 20.30269  -37.45037 1.000 16.99841 ? 241 LEU   A CA  1 
ATOM   1227 C  C   . LEU   A 1 241 ? -11.73038 21.58463  -38.26828 1.000 18.02078 ? 241 LEU   A C   1 
ATOM   1228 O  O   . LEU   A 1 241 ? -10.71835 22.29206  -38.22321 1.000 20.16429 ? 241 LEU   A O   1 
ATOM   1229 C  CB  . LEU   A 1 241 ? -10.91074 19.23748  -38.11233 1.000 14.15148 ? 241 LEU   A CB  1 
ATOM   1230 C  CG  . LEU   A 1 241 ? -10.59942 17.97451  -37.31288 1.000 18.03522 ? 241 LEU   A CG  1 
ATOM   1231 C  CD1 . LEU   A 1 241 ? -10.11223 16.87675  -38.24087 1.000 12.20668 ? 241 LEU   A CD1 1 
ATOM   1232 C  CD2 . LEU   A 1 241 ? -9.55870  18.27819  -36.25230 1.000 14.55971 ? 241 LEU   A CD2 1 
ATOM   1233 N  N   . GLN   A 1 242 ? -12.78716 21.89770  -39.01408 1.000 16.87752 ? 242 GLN   A N   1 
ATOM   1234 C  CA  . GLN   A 1 242 ? -12.82069 23.09082  -39.84595 1.000 20.00835 ? 242 GLN   A CA  1 
ATOM   1235 C  C   . GLN   A 1 242 ? -13.37213 24.30774  -39.11778 1.000 26.15627 ? 242 GLN   A C   1 
ATOM   1236 O  O   . GLN   A 1 242 ? -13.29374 25.41852  -39.65399 1.000 26.12377 ? 242 GLN   A O   1 
ATOM   1237 C  CB  . GLN   A 1 242 ? -13.64555 22.82101  -41.10675 1.000 20.08176 ? 242 GLN   A CB  1 
ATOM   1238 C  CG  . GLN   A 1 242 ? -13.05242 21.73282  -41.98533 1.000 26.36386 ? 242 GLN   A CG  1 
ATOM   1239 C  CD  . GLN   A 1 242 ? -13.98094 21.30942  -43.10365 1.000 36.53578 ? 242 GLN   A CD  1 
ATOM   1240 O  OE1 . GLN   A 1 242 ? -15.07900 21.84529  -43.25110 1.000 39.61161 ? 242 GLN   A OE1 1 
ATOM   1241 N  NE2 . GLN   A 1 242 ? -13.54285 20.34194  -43.90137 1.000 35.80546 ? 242 GLN   A NE2 1 
ATOM   1242 N  N   . GLU   A 1 243 ? -13.91917 24.12952  -37.91790 1.000 21.89227 ? 243 GLU   A N   1 
ATOM   1243 C  CA  . GLU   A 1 243 ? -14.36856 25.26549  -37.13161 1.000 22.54457 ? 243 GLU   A CA  1 
ATOM   1244 C  C   . GLU   A 1 243 ? -13.17832 26.13119  -36.72711 1.000 23.42667 ? 243 GLU   A C   1 
ATOM   1245 O  O   . GLU   A 1 243 ? -12.01556 25.72910  -36.82697 1.000 19.69432 ? 243 GLU   A O   1 
ATOM   1246 C  CB  . GLU   A 1 243 ? -15.13654 24.79390  -35.89736 1.000 21.79944 ? 243 GLU   A CB  1 
ATOM   1247 C  CG  . GLU   A 1 243 ? -16.41456 24.03896  -36.22514 1.000 25.85542 ? 243 GLU   A CG  1 
ATOM   1248 C  CD  . GLU   A 1 243 ? -17.47440 24.93116  -36.84247 1.000 33.09073 ? 243 GLU   A CD  1 
ATOM   1249 O  OE1 . GLU   A 1 243 ? -17.97834 25.83215  -36.13967 1.000 37.21493 ? 243 GLU   A OE1 1 
ATOM   1250 O  OE2 . GLU   A 1 243 ? -17.79779 24.73759  -38.03270 1.000 31.18146 ? 243 GLU   A OE2 1 
ATOM   1251 N  N   . GLU   A 1 244 ? -13.48896 27.33953  -36.26778 1.000 25.89594 ? 244 GLU   A N   1 
ATOM   1252 C  CA  . GLU   A 1 244 ? -12.46312 28.33694  -35.99443 1.000 23.88219 ? 244 GLU   A CA  1 
ATOM   1253 C  C   . GLU   A 1 244 ? -11.46473 27.83452  -34.95570 1.000 19.94352 ? 244 GLU   A C   1 
ATOM   1254 O  O   . GLU   A 1 244 ? -11.84446 27.44696  -33.84632 1.000 20.11769 ? 244 GLU   A O   1 
ATOM   1255 C  CB  . GLU   A 1 244 ? -13.12687 29.62785  -35.52192 1.000 24.94917 ? 244 GLU   A CB  1 
ATOM   1256 C  CG  . GLU   A 1 244 ? -12.21785 30.83486  -35.46979 1.000 26.59503 ? 244 GLU   A CG  1 
ATOM   1257 C  CD  . GLU   A 1 244 ? -12.97563 32.08545  -35.08297 1.000 31.46541 ? 244 GLU   A CD  1 
ATOM   1258 O  OE1 . GLU   A 1 244 ? -13.24619 32.92565  -35.96738 1.000 35.29440 ? 244 GLU   A OE1 1 
ATOM   1259 O  OE2 . GLU   A 1 244 ? -13.32813 32.20889  -33.89320 1.000 29.32070 ? 244 GLU   A OE2 1 
ATOM   1260 N  N   . ASN   A 1 245 ? -10.18220 27.83943  -35.33318 1.000 14.08384 ? 245 ASN   A N   1 
ATOM   1261 C  CA  . ASN   A 1 245 ? -9.07988  27.41256  -34.46483 1.000 18.72338 ? 245 ASN   A CA  1 
ATOM   1262 C  C   . ASN   A 1 245 ? -9.29700  25.99504  -33.93795 1.000 20.45676 ? 245 ASN   A C   1 
ATOM   1263 O  O   . ASN   A 1 245 ? -9.02142  25.68979  -32.77547 1.000 17.97998 ? 245 ASN   A O   1 
ATOM   1264 C  CB  . ASN   A 1 245 ? -8.87305  28.39772  -33.30984 1.000 21.06274 ? 245 ASN   A CB  1 
ATOM   1265 C  CG  . ASN   A 1 245 ? -7.53692  28.20564  -32.60723 1.000 21.43982 ? 245 ASN   A CG  1 
ATOM   1266 O  OD1 . ASN   A 1 245 ? -6.58183  27.69184  -33.19093 1.000 26.52346 ? 245 ASN   A OD1 1 
ATOM   1267 N  ND2 . ASN   A 1 245 ? -7.47048  28.60756  -31.34309 1.000 23.94446 ? 245 ASN   A ND2 1 
ATOM   1268 N  N   . CYS   A 1 246 ? -9.78827  25.11056  -34.80339 1.000 20.31775 ? 246 CYS   A N   1 
ATOM   1269 C  CA  . CYS   A 1 246 ? -10.10278 23.74786  -34.39868 1.000 17.91849 ? 246 CYS   A CA  1 
ATOM   1270 C  C   . CYS   A 1 246 ? -9.28469  22.68604  -35.11974 1.000 17.75567 ? 246 CYS   A C   1 
ATOM   1271 O  O   . CYS   A 1 246 ? -9.38856  21.50770  -34.76526 1.000 16.44146 ? 246 CYS   A O   1 
ATOM   1272 C  CB  . CYS   A 1 246 ? -11.59721 23.46172  -34.60241 1.000 16.31870 ? 246 CYS   A CB  1 
ATOM   1273 S  SG  . CYS   A 1 246 ? -12.67819 24.05016  -33.27409 1.000 19.65217 ? 246 CYS   A SG  1 
ATOM   1274 N  N   . ASP   A 1 247 ? -8.47516  23.05192  -36.11044 1.000 22.44654 ? 247 ASP   A N   1 
ATOM   1275 C  CA  . ASP   A 1 247 ? -7.72948  22.04028  -36.85850 1.000 20.41621 ? 247 ASP   A CA  1 
ATOM   1276 C  C   . ASP   A 1 247 ? -6.48413  21.65718  -36.07012 1.000 21.97021 ? 247 ASP   A C   1 
ATOM   1277 O  O   . ASP   A 1 247 ? -5.41520  22.25066  -36.21902 1.000 20.80043 ? 247 ASP   A O   1 
ATOM   1278 C  CB  . ASP   A 1 247 ? -7.37015  22.53419  -38.25250 1.000 17.96116 ? 247 ASP   A CB  1 
ATOM   1279 C  CG  . ASP   A 1 247 ? -6.69844  21.45990  -39.08370 1.000 26.47947 ? 247 ASP   A CG  1 
ATOM   1280 O  OD1 . ASP   A 1 247 ? -6.81755  20.27065  -38.71655 1.000 21.76309 ? 247 ASP   A OD1 1 
ATOM   1281 O  OD2 . ASP   A 1 247 ? -6.05887  21.79631  -40.10075 1.000 27.30598 ? 247 ASP   A OD2 1 
ATOM   1282 N  N   . ILE   A 1 248 ? -6.62246  20.62932  -35.22904 1.000 15.85219 ? 248 ILE   A N   1 
ATOM   1283 C  CA  . ILE   A 1 248 ? -5.49135  20.12139  -34.46169 1.000 15.22269 ? 248 ILE   A CA  1 
ATOM   1284 C  C   . ILE   A 1 248 ? -4.45476  19.42486  -35.32722 1.000 16.94823 ? 248 ILE   A C   1 
ATOM   1285 O  O   . ILE   A 1 248 ? -3.36029  19.11868  -34.84155 1.000 14.98318 ? 248 ILE   A O   1 
ATOM   1286 C  CB  . ILE   A 1 248 ? -5.97797  19.15336  -33.36627 1.000 15.16182 ? 248 ILE   A CB  1 
ATOM   1287 C  CG1 . ILE   A 1 248 ? -6.69621  17.96168  -33.99794 1.000 14.49813 ? 248 ILE   A CG1 1 
ATOM   1288 C  CG2 . ILE   A 1 248 ? -6.89152  19.87033  -32.39185 1.000 15.28086 ? 248 ILE   A CG2 1 
ATOM   1289 C  CD1 . ILE   A 1 248 ? -7.00601  16.85725  -33.02002 1.000 12.59078 ? 248 ILE   A CD1 1 
ATOM   1290 N  N   . PHE   A 1 249 ? -4.76904  19.16393  -36.59379 1.000 17.85635 ? 249 PHE   A N   1 
ATOM   1291 C  CA  . PHE   A 1 249 ? -3.84400  18.52704  -37.51904 1.000 21.14464 ? 249 PHE   A CA  1 
ATOM   1292 C  C   . PHE   A 1 249 ? -3.20811  19.52106  -38.48013 1.000 19.67130 ? 249 PHE   A C   1 
ATOM   1293 O  O   . PHE   A 1 249 ? -2.61874  19.10816  -39.48404 1.000 20.22991 ? 249 PHE   A O   1 
ATOM   1294 C  CB  . PHE   A 1 249 ? -4.56436  17.42808  -38.30013 1.000 13.58528 ? 249 PHE   A CB  1 
ATOM   1295 C  CG  . PHE   A 1 249 ? -5.24997  16.42194  -37.42492 1.000 14.43789 ? 249 PHE   A CG  1 
ATOM   1296 C  CD1 . PHE   A 1 249 ? -4.52814  15.69834  -36.49083 1.000 12.16679 ? 249 PHE   A CD1 1 
ATOM   1297 C  CD2 . PHE   A 1 249 ? -6.61447  16.20295  -37.53010 1.000 13.82089 ? 249 PHE   A CD2 1 
ATOM   1298 C  CE1 . PHE   A 1 249 ? -5.15118  14.77234  -35.67767 1.000 16.83438 ? 249 PHE   A CE1 1 
ATOM   1299 C  CE2 . PHE   A 1 249 ? -7.24549  15.27660  -36.72015 1.000 16.63562 ? 249 PHE   A CE2 1 
ATOM   1300 C  CZ  . PHE   A 1 249 ? -6.51221  14.56004  -35.79219 1.000 13.15940 ? 249 PHE   A CZ  1 
ATOM   1301 N  N   . GLN   A 1 250 ? -3.29793  20.81923  -38.17990 1.000 17.68146 ? 250 GLN   A N   1 
ATOM   1302 C  CA  . GLN   A 1 250 ? -2.88544  21.85606  -39.11960 1.000 21.87634 ? 250 GLN   A CA  1 
ATOM   1303 C  C   . GLN   A 1 250 ? -1.40509  21.78942  -39.47383 1.000 19.19079 ? 250 GLN   A C   1 
ATOM   1304 O  O   . GLN   A 1 250 ? -1.00984  22.31478  -40.51979 1.000 19.36113 ? 250 GLN   A O   1 
ATOM   1305 C  CB  . GLN   A 1 250 ? -3.21653  23.23411  -38.54431 1.000 17.15801 ? 250 GLN   A CB  1 
ATOM   1306 C  CG  . GLN   A 1 250 ? -2.57679  23.50909  -37.19061 1.000 19.75968 ? 250 GLN   A CG  1 
ATOM   1307 C  CD  . GLN   A 1 250 ? -3.01535  24.83379  -36.59235 1.000 25.97471 ? 250 GLN   A CD  1 
ATOM   1308 O  OE1 . GLN   A 1 250 ? -4.10948  24.94608  -36.03841 1.000 24.49277 ? 250 GLN   A OE1 1 
ATOM   1309 N  NE2 . GLN   A 1 250 ? -2.16005  25.84480  -36.69995 1.000 22.05725 ? 250 GLN   A NE2 1 
ATOM   1310 N  N   . ASN   A 1 251 ? -0.57680  21.16608  -38.63752 1.000 15.68170 ? 251 ASN   A N   1 
ATOM   1311 C  CA  . ASN   A 1 251 ? 0.85778   21.10155  -38.88450 1.000 18.85909 ? 251 ASN   A CA  1 
ATOM   1312 C  C   . ASN   A 1 251 ? 1.32985   19.70507  -39.26718 1.000 17.91921 ? 251 ASN   A C   1 
ATOM   1313 O  O   . ASN   A 1 251 ? 2.53968   19.45864  -39.30923 1.000 20.47925 ? 251 ASN   A O   1 
ATOM   1314 C  CB  . ASN   A 1 251 ? 1.62687   21.61304  -37.66528 1.000 17.45373 ? 251 ASN   A CB  1 
ATOM   1315 C  CG  . ASN   A 1 251 ? 1.45056   23.10572  -37.45361 1.000 18.65286 ? 251 ASN   A CG  1 
ATOM   1316 O  OD1 . ASN   A 1 251 ? 1.31868   23.86947  -38.41180 1.000 17.99046 ? 251 ASN   A OD1 1 
ATOM   1317 N  ND2 . ASN   A 1 251 ? 1.44833   23.52889  -36.19604 1.000 16.97620 ? 251 ASN   A ND2 1 
ATOM   1318 N  N   . LEU   A 1 252 ? 0.41068   18.78785  -39.54378 1.000 17.40516 ? 252 LEU   A N   1 
ATOM   1319 C  CA  . LEU   A 1 252 ? 0.78168   17.51987  -40.14693 1.000 19.68821 ? 252 LEU   A CA  1 
ATOM   1320 C  C   . LEU   A 1 252 ? 1.06972   17.72489  -41.62740 1.000 18.03705 ? 252 LEU   A C   1 
ATOM   1321 O  O   . LEU   A 1 252 ? 0.50387   18.61200  -42.27037 1.000 19.59237 ? 252 LEU   A O   1 
ATOM   1322 C  CB  . LEU   A 1 252 ? -0.33146  16.48647  -39.97134 1.000 16.68516 ? 252 LEU   A CB  1 
ATOM   1323 C  CG  . LEU   A 1 252 ? -0.35447  15.65381  -38.68768 1.000 15.09060 ? 252 LEU   A CG  1 
ATOM   1324 C  CD1 . LEU   A 1 252 ? -0.41629  16.52715  -37.44335 1.000 14.25895 ? 252 LEU   A CD1 1 
ATOM   1325 C  CD2 . LEU   A 1 252 ? -1.52058  14.68142  -38.71684 1.000 15.69893 ? 252 LEU   A CD2 1 
ATOM   1326 N  N   . THR   A 1 253 ? 1.97126   16.90643  -42.16390 1.000 20.42745 ? 253 THR   A N   1 
ATOM   1327 C  CA  . THR   A 1 253 ? 2.20872   16.93363  -43.59746 1.000 22.41181 ? 253 THR   A CA  1 
ATOM   1328 C  C   . THR   A 1 253 ? 0.99071   16.39406  -44.33632 1.000 23.73090 ? 253 THR   A C   1 
ATOM   1329 O  O   . THR   A 1 253 ? 0.07498   15.81656  -43.74323 1.000 18.45168 ? 253 THR   A O   1 
ATOM   1330 C  CB  . THR   A 1 253 ? 3.43768   16.10931  -43.97531 1.000 21.29395 ? 253 THR   A CB  1 
ATOM   1331 O  OG1 . THR   A 1 253 ? 3.16410   14.71985  -43.75945 1.000 18.35589 ? 253 THR   A OG1 1 
ATOM   1332 C  CG2 . THR   A 1 253 ? 4.63563   16.52833  -43.14347 1.000 19.77732 ? 253 THR   A CG2 1 
ATOM   1333 N  N   . LYS   A 1 254 ? 0.98832   16.59082  -45.65610 1.000 23.30323 ? 254 LYS   A N   1 
ATOM   1334 C  CA  . LYS   A 1 254 ? -0.14507  16.14000  -46.45627 1.000 23.39242 ? 254 LYS   A CA  1 
ATOM   1335 C  C   . LYS   A 1 254 ? -0.27938  14.62444  -46.41009 1.000 23.08589 ? 254 LYS   A C   1 
ATOM   1336 O  O   . LYS   A 1 254 ? -1.38909  14.09469  -46.27555 1.000 23.39170 ? 254 LYS   A O   1 
ATOM   1337 C  CB  . LYS   A 1 254 ? -0.01209  16.63342  -47.90368 1.000 24.66931 ? 254 LYS   A CB  1 
ATOM   1338 C  CG  . LYS   A 1 254 ? -0.44591  18.10162  -48.22915 1.000 31.37884 ? 254 LYS   A CG  1 
ATOM   1339 C  CD  . LYS   A 1 254 ? -1.88912  18.49675  -47.79290 1.000 38.10319 ? 254 LYS   A CD  1 
ATOM   1340 C  CE  . LYS   A 1 254 ? -2.01601  18.86483  -46.28884 1.000 44.73357 ? 254 LYS   A CE  1 
ATOM   1341 N  NZ  . LYS   A 1 254 ? -3.24216  19.62450  -45.81162 1.000 47.43251 ? 254 LYS   A NZ  1 
ATOM   1342 N  N   . LYS   A 1 255 ? 0.84024   13.90796  -46.51085 1.000 22.12585 ? 255 LYS   A N   1 
ATOM   1343 C  CA  . LYS   A 1 255 ? 0.78470   12.45558  -46.41148 1.000 23.80083 ? 255 LYS   A CA  1 
ATOM   1344 C  C   . LYS   A 1 255 ? 0.36589   12.01121  -45.01532 1.000 18.43030 ? 255 LYS   A C   1 
ATOM   1345 O  O   . LYS   A 1 255 ? -0.32400  10.99608  -44.87125 1.000 18.08003 ? 255 LYS   A O   1 
ATOM   1346 C  CB  . LYS   A 1 255 ? 2.13683   11.86493  -46.80660 1.000 23.07437 ? 255 LYS   A CB  1 
ATOM   1347 C  CG  . LYS   A 1 255 ? 2.29907   11.75885  -48.31545 1.000 35.01225 ? 255 LYS   A CG  1 
ATOM   1348 C  CD  . LYS   A 1 255 ? 3.70732   12.08914  -48.76739 1.000 38.03694 ? 255 LYS   A CD  1 
ATOM   1349 C  CE  . LYS   A 1 255 ? 3.91025   11.69775  -50.22109 1.000 41.92046 ? 255 LYS   A CE  1 
ATOM   1350 N  NZ  . LYS   A 1 255 ? 5.19638   10.97114  -50.40210 1.000 44.04329 ? 255 LYS   A NZ  1 
ATOM   1351 N  N   . GLN   A 1 256 ? 0.73517   12.77534  -43.98190 1.000 16.88392 ? 256 GLN   A N   1 
ATOM   1352 C  CA  . GLN   A 1 256 ? 0.33197   12.42751  -42.62094 1.000 18.00973 ? 256 GLN   A CA  1 
ATOM   1353 C  C   . GLN   A 1 256 ? -1.17675  12.54353  -42.44158 1.000 16.07610 ? 256 GLN   A C   1 
ATOM   1354 O  O   . GLN   A 1 256 ? -1.81459  11.64936  -41.87398 1.000 13.45364 ? 256 GLN   A O   1 
ATOM   1355 C  CB  . GLN   A 1 256 ? 1.05886   13.31140  -41.60675 1.000 16.02858 ? 256 GLN   A CB  1 
ATOM   1356 C  CG  . GLN   A 1 256 ? 2.47997   12.87412  -41.30352 1.000 18.53095 ? 256 GLN   A CG  1 
ATOM   1357 C  CD  . GLN   A 1 256 ? 3.22329   13.88686  -40.45967 1.000 19.14219 ? 256 GLN   A CD  1 
ATOM   1358 O  OE1 . GLN   A 1 256 ? 3.04140   15.09313  -40.61894 1.000 22.10010 ? 256 GLN   A OE1 1 
ATOM   1359 N  NE2 . GLN   A 1 256 ? 4.06123   13.40218  -39.54994 1.000 24.97744 ? 256 GLN   A NE2 1 
ATOM   1360 N  N   . ARG   A 1 257 ? -1.76657  13.64301  -42.91285 1.000 15.64910 ? 257 ARG   A N   1 
ATOM   1361 C  CA  . ARG   A 1 257 ? -3.20897  13.81289  -42.77272 1.000 18.41030 ? 257 ARG   A CA  1 
ATOM   1362 C  C   . ARG   A 1 257 ? -3.96939  12.78444  -43.59520 1.000 15.58080 ? 257 ARG   A C   1 
ATOM   1363 O  O   . ARG   A 1 257 ? -4.95983  12.21289  -43.12498 1.000 18.09524 ? 257 ARG   A O   1 
ATOM   1364 C  CB  . ARG   A 1 257 ? -3.61112  15.22530  -43.17970 1.000 21.70156 ? 257 ARG   A CB  1 
ATOM   1365 C  CG  . ARG   A 1 257 ? -2.82960  16.29475  -42.46338 1.000 23.67038 ? 257 ARG   A CG  1 
ATOM   1366 C  CD  . ARG   A 1 257 ? -2.99289  17.61244  -43.17569 1.000 25.89397 ? 257 ARG   A CD  1 
ATOM   1367 N  NE  . ARG   A 1 257 ? -4.18190  18.33800  -42.74947 1.000 32.09339 ? 257 ARG   A NE  1 
ATOM   1368 C  CZ  . ARG   A 1 257 ? -4.15475  19.60944  -42.37108 1.000 39.42930 ? 257 ARG   A CZ  1 
ATOM   1369 N  NH1 . ARG   A 1 257 ? -3.00436  20.26560  -42.40756 1.000 37.80884 ? 257 ARG   A NH1 1 
ATOM   1370 N  NH2 . ARG   A 1 257 ? -5.26253  20.23186  -41.98350 1.000 34.97424 ? 257 ARG   A NH2 1 
ATOM   1371 N  N   . GLN   A 1 258 ? -3.52894  12.54801  -44.83159 1.000 14.23239 ? 258 GLN   A N   1 
ATOM   1372 C  CA  . GLN   A 1 258 ? -4.15267  11.52507  -45.66272 1.000 16.26361 ? 258 GLN   A CA  1 
ATOM   1373 C  C   . GLN   A 1 258 ? -4.09444  10.16220  -44.98321 1.000 15.80741 ? 258 GLN   A C   1 
ATOM   1374 O  O   . GLN   A 1 258 ? -5.10327  9.45143   -44.90042 1.000 13.03133 ? 258 GLN   A O   1 
ATOM   1375 C  CB  . GLN   A 1 258 ? -3.46661  11.48666  -47.02792 1.000 16.71007 ? 258 GLN   A CB  1 
ATOM   1376 C  CG  . GLN   A 1 258 ? -3.93075  10.37085  -47.94008 1.000 21.17040 ? 258 GLN   A CG  1 
ATOM   1377 C  CD  . GLN   A 1 258 ? -3.19746  10.37630  -49.26610 1.000 29.05796 ? 258 GLN   A CD  1 
ATOM   1378 O  OE1 . GLN   A 1 258 ? -3.76575  10.72285  -50.30124 1.000 31.75557 ? 258 GLN   A OE1 1 
ATOM   1379 N  NE2 . GLN   A 1 258 ? -1.92401  9.99915   -49.23986 1.000 27.84906 ? 258 GLN   A NE2 1 
ATOM   1380 N  N   . SER   A 1 259 ? -2.91702  9.78918   -44.47402 1.000 14.35739 ? 259 SER   A N   1 
ATOM   1381 C  CA  . SER   A 1 259 ? -2.77663  8.50881   -43.78766 1.000 16.79687 ? 259 SER   A CA  1 
ATOM   1382 C  C   . SER   A 1 259 ? -3.62134  8.46091   -42.52118 1.000 14.50350 ? 259 SER   A C   1 
ATOM   1383 O  O   . SER   A 1 259 ? -4.29432  7.45813   -42.25436 1.000 16.00547 ? 259 SER   A O   1 
ATOM   1384 C  CB  . SER   A 1 259 ? -1.30839  8.24634   -43.45608 1.000 16.98757 ? 259 SER   A CB  1 
ATOM   1385 O  OG  . SER   A 1 259 ? -1.18929  7.23319   -42.47346 1.000 21.68219 ? 259 SER   A OG  1 
ATOM   1386 N  N   . LEU   A 1 260 ? -3.59759  9.53242   -41.72394 1.000 14.48907 ? 260 LEU   A N   1 
ATOM   1387 C  CA  . LEU   A 1 260 ? -4.39146  9.54374   -40.49951 1.000 12.09642 ? 260 LEU   A CA  1 
ATOM   1388 C  C   . LEU   A 1 260 ? -5.88042  9.47722   -40.80694 1.000 11.76935 ? 260 LEU   A C   1 
ATOM   1389 O  O   . LEU   A 1 260 ? -6.62559  8.75276   -40.13683 1.000 11.79574 ? 260 LEU   A O   1 
ATOM   1390 C  CB  . LEU   A 1 260 ? -4.08042  10.78395  -39.66061 1.000 13.89571 ? 260 LEU   A CB  1 
ATOM   1391 C  CG  . LEU   A 1 260 ? -4.96009  10.88724  -38.40494 1.000 14.93894 ? 260 LEU   A CG  1 
ATOM   1392 C  CD1 . LEU   A 1 260 ? -4.13083  11.15299  -37.16039 1.000 14.67311 ? 260 LEU   A CD1 1 
ATOM   1393 C  CD2 . LEU   A 1 260 ? -6.05662  11.94387  -38.55569 1.000 12.25060 ? 260 LEU   A CD2 1 
ATOM   1394 N  N   . ARG   A 1 261 ? -6.33550  10.22979  -41.81173 1.000 10.23684 ? 261 ARG   A N   1 
ATOM   1395 C  CA  . ARG   A 1 261 ? -7.75783  10.23174  -42.13705 1.000 13.38066 ? 261 ARG   A CA  1 
ATOM   1396 C  C   . ARG   A 1 261 ? -8.23824  8.83278   -42.49991 1.000 12.46871 ? 261 ARG   A C   1 
ATOM   1397 O  O   . ARG   A 1 261 ? -9.29001  8.38628   -42.02894 1.000 9.14668  ? 261 ARG   A O   1 
ATOM   1398 C  CB  . ARG   A 1 261 ? -8.04897  11.21163  -43.27370 1.000 11.56849 ? 261 ARG   A CB  1 
ATOM   1399 C  CG  . ARG   A 1 261 ? -9.49165  11.14955  -43.75579 1.000 14.30648 ? 261 ARG   A CG  1 
ATOM   1400 C  CD  . ARG   A 1 261 ? -9.82806  12.27142  -44.72881 1.000 15.93792 ? 261 ARG   A CD  1 
ATOM   1401 N  NE  . ARG   A 1 261 ? -11.11106 12.03569  -45.38818 1.000 14.17556 ? 261 ARG   A NE  1 
ATOM   1402 C  CZ  . ARG   A 1 261 ? -12.29392 12.31958  -44.85106 1.000 12.06149 ? 261 ARG   A CZ  1 
ATOM   1403 N  NH1 . ARG   A 1 261 ? -12.36476 12.85605  -43.64115 1.000 12.37004 ? 261 ARG   A NH1 1 
ATOM   1404 N  NH2 . ARG   A 1 261 ? -13.40858 12.06473  -45.52332 1.000 12.84654 ? 261 ARG   A NH2 1 
ATOM   1405 N  N   . LYS   A 1 262 ? -7.47204  8.11753   -43.32820 1.000 12.07411 ? 262 LYS   A N   1 
ATOM   1406 C  CA  . LYS   A 1 262 ? -7.87512  6.76667   -43.70613 1.000 14.45363 ? 262 LYS   A CA  1 
ATOM   1407 C  C   . LYS   A 1 262 ? -7.88064  5.83270   -42.50281 1.000 10.91086 ? 262 LYS   A C   1 
ATOM   1408 O  O   . LYS   A 1 262 ? -8.79603  5.01589   -42.34828 1.000 10.93114 ? 262 LYS   A O   1 
ATOM   1409 C  CB  . LYS   A 1 262 ? -6.95850  6.21438   -44.79648 1.000 17.85092 ? 262 LYS   A CB  1 
ATOM   1410 C  CG  . LYS   A 1 262 ? -7.32559  4.79580   -45.20227 1.000 15.71771 ? 262 LYS   A CG  1 
ATOM   1411 C  CD  . LYS   A 1 262 ? -6.33890  4.20306   -46.18401 1.000 22.01856 ? 262 LYS   A CD  1 
ATOM   1412 C  CE  . LYS   A 1 262 ? -6.78354  2.81388   -46.60760 1.000 24.91371 ? 262 LYS   A CE  1 
ATOM   1413 N  NZ  . LYS   A 1 262 ? -8.15457  2.82657   -47.19292 1.000 28.43276 ? 262 LYS   A NZ  1 
ATOM   1414 N  N   . MET   A 1 263 ? -6.86506  5.93401   -41.64135 1.000 12.00758 ? 263 MET   A N   1 
ATOM   1415 C  CA  . MET   A 1 263 ? -6.80389  5.07094   -40.46524 1.000 11.36628 ? 263 MET   A CA  1 
ATOM   1416 C  C   . MET   A 1 263 ? -7.97560  5.33763   -39.52844 1.000 11.26902 ? 263 MET   A C   1 
ATOM   1417 O  O   . MET   A 1 263 ? -8.60683  4.40187   -39.02374 1.000 8.11543  ? 263 MET   A O   1 
ATOM   1418 C  CB  . MET   A 1 263 ? -5.47291  5.26471   -39.73665 1.000 11.58095 ? 263 MET   A CB  1 
ATOM   1419 C  CG  . MET   A 1 263 ? -4.28025  4.65943   -40.45988 1.000 14.24592 ? 263 MET   A CG  1 
ATOM   1420 S  SD  . MET   A 1 263 ? -2.78744  4.59989   -39.44953 1.000 15.60816 ? 263 MET   A SD  1 
ATOM   1421 C  CE  . MET   A 1 263 ? -2.35114  6.33500   -39.36952 1.000 12.70134 ? 263 MET   A CE  1 
ATOM   1422 N  N   . VAL   A 1 264 ? -8.28374  6.61550   -39.28940 1.000 10.48782 ? 264 VAL   A N   1 
ATOM   1423 C  CA  . VAL   A 1 264 ? -9.40731  6.96566   -38.42348 1.000 11.55022 ? 264 VAL   A CA  1 
ATOM   1424 C  C   . VAL   A 1 264 ? -10.70909 6.41120   -38.98838 1.000 9.54361  ? 264 VAL   A C   1 
ATOM   1425 O  O   . VAL   A 1 264 ? -11.54999 5.88330   -38.24942 1.000 9.73168  ? 264 VAL   A O   1 
ATOM   1426 C  CB  . VAL   A 1 264 ? -9.47701  8.49256   -38.22987 1.000 10.41353 ? 264 VAL   A CB  1 
ATOM   1427 C  CG1 . VAL   A 1 264 ? -10.77583 8.88211   -37.55006 1.000 8.25563  ? 264 VAL   A CG1 1 
ATOM   1428 C  CG2 . VAL   A 1 264 ? -8.28912  8.98114   -37.41367 1.000 13.68910 ? 264 VAL   A CG2 1 
ATOM   1429 N  N   . ILE   A 1 265 ? -10.88980 6.51025   -40.30756 1.000 9.73863  ? 265 ILE   A N   1 
ATOM   1430 C  CA  . ILE   A 1 265 ? -12.10056 5.99074   -40.93986 1.000 9.84574  ? 265 ILE   A CA  1 
ATOM   1431 C  C   . ILE   A 1 265 ? -12.18378 4.47905   -40.76957 1.000 10.71836 ? 265 ILE   A C   1 
ATOM   1432 O  O   . ILE   A 1 265 ? -13.22120 3.93840   -40.36794 1.000 8.74915  ? 265 ILE   A O   1 
ATOM   1433 C  CB  . ILE   A 1 265 ? -12.14634 6.39308   -42.42464 1.000 9.74175  ? 265 ILE   A CB  1 
ATOM   1434 C  CG1 . ILE   A 1 265 ? -12.36873 7.90050   -42.56333 1.000 10.65151 ? 265 ILE   A CG1 1 
ATOM   1435 C  CG2 . ILE   A 1 265 ? -13.23525 5.62046   -43.14975 1.000 9.36411  ? 265 ILE   A CG2 1 
ATOM   1436 C  CD1 . ILE   A 1 265 ? -12.13048 8.42798   -43.96217 1.000 9.06919  ? 265 ILE   A CD1 1 
ATOM   1437 N  N   . ASP   A 1 266 ? -11.09022 3.77444   -41.07580 1.000 9.42729  ? 266 ASP   A N   1 
ATOM   1438 C  CA  . ASP   A 1 266 ? -11.07610 2.32195   -40.92579 1.000 9.81107  ? 266 ASP   A CA  1 
ATOM   1439 C  C   . ASP   A 1 266 ? -11.39090 1.90780   -39.49495 1.000 12.36783 ? 266 ASP   A C   1 
ATOM   1440 O  O   . ASP   A 1 266 ? -12.07685 0.90455   -39.26720 1.000 11.93988 ? 266 ASP   A O   1 
ATOM   1441 C  CB  . ASP   A 1 266 ? -9.71908  1.76022   -41.34817 1.000 10.93346 ? 266 ASP   A CB  1 
ATOM   1442 C  CG  . ASP   A 1 266 ? -9.47763  1.87805   -42.83618 1.000 11.76121 ? 266 ASP   A CG  1 
ATOM   1443 O  OD1 . ASP   A 1 266 ? -10.45087 2.12564   -43.57618 1.000 10.66021 ? 266 ASP   A OD1 1 
ATOM   1444 O  OD2 . ASP   A 1 266 ? -8.31691  1.71576   -43.26758 1.000 11.36429 ? 266 ASP   A OD2 1 
ATOM   1445 N  N   . ILE   A 1 267 ? -10.90452 2.67176   -38.51700 1.000 13.28478 ? 267 ILE   A N   1 
ATOM   1446 C  CA  . ILE   A 1 267 ? -11.08167 2.28837   -37.12065 1.000 10.14633 ? 267 ILE   A CA  1 
ATOM   1447 C  C   . ILE   A 1 267 ? -12.52267 2.51488   -36.67727 1.000 9.68442  ? 267 ILE   A C   1 
ATOM   1448 O  O   . ILE   A 1 267 ? -13.14799 1.63231   -36.07848 1.000 10.09656 ? 267 ILE   A O   1 
ATOM   1449 C  CB  . ILE   A 1 267 ? -10.08693 3.04824   -36.22631 1.000 14.89312 ? 267 ILE   A CB  1 
ATOM   1450 C  CG1 . ILE   A 1 267 ? -8.67230  2.49660   -36.42320 1.000 10.82020 ? 267 ILE   A CG1 1 
ATOM   1451 C  CG2 . ILE   A 1 267 ? -10.50566 2.95151   -34.77263 1.000 8.10252  ? 267 ILE   A CG2 1 
ATOM   1452 C  CD1 . ILE   A 1 267 ? -7.57893  3.40722   -35.90606 1.000 12.01890 ? 267 ILE   A CD1 1 
ATOM   1453 N  N   . VAL   A 1 268 ? -13.07272 3.69840   -36.96042 1.000 9.90738  ? 268 VAL   A N   1 
ATOM   1454 C  CA  . VAL   A 1 268 ? -14.41480 4.01685   -36.47850 1.000 9.03497  ? 268 VAL   A CA  1 
ATOM   1455 C  C   . VAL   A 1 268 ? -15.45784 3.14538   -37.16575 1.000 10.43519 ? 268 VAL   A C   1 
ATOM   1456 O  O   . VAL   A 1 268 ? -16.42469 2.69955   -36.53497 1.000 10.28863 ? 268 VAL   A O   1 
ATOM   1457 C  CB  . VAL   A 1 268 ? -14.71538 5.51322   -36.66761 1.000 11.41345 ? 268 VAL   A CB  1 
ATOM   1458 C  CG1 . VAL   A 1 268 ? -16.16858 5.80873   -36.32636 1.000 7.55997  ? 268 VAL   A CG1 1 
ATOM   1459 C  CG2 . VAL   A 1 268 ? -13.79173 6.34722   -35.80017 1.000 9.17354  ? 268 VAL   A CG2 1 
ATOM   1460 N  N   . LEU   A 1 269 ? -15.28743 2.88944   -38.46562 1.000 8.86386  ? 269 LEU   A N   1 
ATOM   1461 C  CA  . LEU   A 1 269 ? -16.20759 1.98872   -39.15092 1.000 10.19870 ? 269 LEU   A CA  1 
ATOM   1462 C  C   . LEU   A 1 269 ? -16.18135 0.59773   -38.53480 1.000 11.81605 ? 269 LEU   A C   1 
ATOM   1463 O  O   . LEU   A 1 269 ? -17.18802 -0.11803  -38.57501 1.000 10.29929 ? 269 LEU   A O   1 
ATOM   1464 C  CB  . LEU   A 1 269 ? -15.88053 1.92524   -40.64365 1.000 8.87991  ? 269 LEU   A CB  1 
ATOM   1465 C  CG  . LEU   A 1 269 ? -16.26931 3.17989   -41.42860 1.000 11.04609 ? 269 LEU   A CG  1 
ATOM   1466 C  CD1 . LEU   A 1 269 ? -15.95906 3.02476   -42.90965 1.000 9.21948  ? 269 LEU   A CD1 1 
ATOM   1467 C  CD2 . LEU   A 1 269 ? -17.74304 3.48889   -41.21343 1.000 9.30107  ? 269 LEU   A CD2 1 
ATOM   1468 N  N   . ALA   A 1 270 ? -15.05460 0.21025   -37.93497 1.000 12.04312 ? 270 ALA   A N   1 
ATOM   1469 C  CA  . ALA   A 1 270 ? -14.95295 -1.08736  -37.28214 1.000 13.37411 ? 270 ALA   A CA  1 
ATOM   1470 C  C   . ALA   A 1 270 ? -15.66360 -1.13791  -35.93362 1.000 14.19264 ? 270 ALA   A C   1 
ATOM   1471 O  O   . ALA   A 1 270 ? -15.78056 -2.22723  -35.36187 1.000 10.38078 ? 270 ALA   A O   1 
ATOM   1472 C  CB  . ALA   A 1 270 ? -13.48185 -1.47019  -37.10929 1.000 12.33788 ? 270 ALA   A CB  1 
ATOM   1473 N  N   . THR   A 1 271 ? -16.13685 -0.00523  -35.40730 1.000 12.62741 ? 271 THR   A N   1 
ATOM   1474 C  CA  . THR   A 1 271 ? -16.90757 -0.03692  -34.16909 1.000 11.57648 ? 271 THR   A CA  1 
ATOM   1475 C  C   . THR   A 1 271 ? -18.35506 -0.45424  -34.38909 1.000 11.95701 ? 271 THR   A C   1 
ATOM   1476 O  O   . THR   A 1 271 ? -19.04971 -0.75880  -33.41265 1.000 13.09188 ? 271 THR   A O   1 
ATOM   1477 C  CB  . THR   A 1 271 ? -16.87135 1.32650   -33.46938 1.000 12.43032 ? 271 THR   A CB  1 
ATOM   1478 O  OG1 . THR   A 1 271 ? -17.40993 2.33244   -34.33524 1.000 8.29835  ? 271 THR   A OG1 1 
ATOM   1479 C  CG2 . THR   A 1 271 ? -15.44658 1.69316   -33.09010 1.000 9.05752  ? 271 THR   A CG2 1 
ATOM   1480 N  N   . ASP   A 1 272 ? -18.81933 -0.46834  -35.63653 1.000 9.03882  ? 272 ASP   A N   1 
ATOM   1481 C  CA  . ASP   A 1 272 ? -20.14426 -0.98342  -35.95595 1.000 11.94540 ? 272 ASP   A CA  1 
ATOM   1482 C  C   . ASP   A 1 272 ? -20.23261 -2.45275  -35.55927 1.000 14.78541 ? 272 ASP   A C   1 
ATOM   1483 O  O   . ASP   A 1 272 ? -19.48468 -3.28686  -36.07845 1.000 14.51721 ? 272 ASP   A O   1 
ATOM   1484 C  CB  . ASP   A 1 272 ? -20.41222 -0.80549  -37.45247 1.000 12.70921 ? 272 ASP   A CB  1 
ATOM   1485 C  CG  . ASP   A 1 272 ? -21.81524 -1.22571  -37.86252 1.000 11.55778 ? 272 ASP   A CG  1 
ATOM   1486 O  OD1 . ASP   A 1 272 ? -22.56469 -1.76648  -37.02407 1.000 14.74452 ? 272 ASP   A OD1 1 
ATOM   1487 O  OD2 . ASP   A 1 272 ? -22.17038 -1.01640  -39.04143 1.000 14.71906 ? 272 ASP   A OD2 1 
ATOM   1488 N  N   . MET   A 1 273 ? -21.15091 -2.76930  -34.63823 1.000 12.31641 ? 273 MET   A N   1 
ATOM   1489 C  CA  . MET   A 1 273 ? -21.27354 -4.13942  -34.14541 1.000 16.44874 ? 273 MET   A CA  1 
ATOM   1490 C  C   . MET   A 1 273 ? -21.58712 -5.13787  -35.25079 1.000 16.91951 ? 273 MET   A C   1 
ATOM   1491 O  O   . MET   A 1 273 ? -21.29055 -6.32698  -35.09338 1.000 15.95956 ? 273 MET   A O   1 
ATOM   1492 C  CB  . MET   A 1 273 ? -22.34769 -4.23219  -33.05834 1.000 14.60815 ? 273 MET   A CB  1 
ATOM   1493 C  CG  . MET   A 1 273 ? -21.80842 -4.16237  -31.63511 1.000 28.07233 ? 273 MET   A CG  1 
ATOM   1494 S  SD  . MET   A 1 273 ? -20.71488 -5.52228  -31.17798 1.000 25.95334 ? 273 MET   A SD  1 
ATOM   1495 C  CE  . MET   A 1 273 ? -21.73216 -6.94444  -31.56807 1.000 25.05447 ? 273 MET   A CE  1 
ATOM   1496 N  N   . SER   A 1 274 ? -22.17558 -4.69251  -36.36308 1.000 16.71797 ? 274 SER   A N   1 
ATOM   1497 C  CA  . SER   A 1 274 ? -22.42056 -5.60582  -37.47308 1.000 21.57035 ? 274 SER   A CA  1 
ATOM   1498 C  C   . SER   A 1 274 ? -21.13052 -6.08922  -38.12321 1.000 19.63618 ? 274 SER   A C   1 
ATOM   1499 O  O   . SER   A 1 274 ? -21.17121 -7.04547  -38.90396 1.000 21.26512 ? 274 SER   A O   1 
ATOM   1500 C  CB  . SER   A 1 274 ? -23.32146 -4.94471  -38.52096 1.000 20.63252 ? 274 SER   A CB  1 
ATOM   1501 O  OG  . SER   A 1 274 ? -22.66909 -3.86765  -39.16996 1.000 26.99415 ? 274 SER   A OG  1 
ATOM   1502 N  N   . LYS   A 1 275 ? -19.99666 -5.45869  -37.81780 1.000 18.34346 ? 275 LYS   A N   1 
ATOM   1503 C  CA  . LYS   A 1 275 ? -18.68904 -5.91121  -38.27135 1.000 15.12284 ? 275 LYS   A CA  1 
ATOM   1504 C  C   . LYS   A 1 275 ? -18.01223 -6.85460  -37.28640 1.000 13.63765 ? 275 LYS   A C   1 
ATOM   1505 O  O   . LYS   A 1 275 ? -16.94001 -7.38294  -37.59961 1.000 12.82530 ? 275 LYS   A O   1 
ATOM   1506 C  CB  . LYS   A 1 275 ? -17.76513 -4.71107  -38.50490 1.000 12.91016 ? 275 LYS   A CB  1 
ATOM   1507 C  CG  . LYS   A 1 275 ? -18.36482 -3.59324  -39.33499 1.000 13.97363 ? 275 LYS   A CG  1 
ATOM   1508 C  CD  . LYS   A 1 275 ? -18.52830 -4.01275  -40.78064 1.000 22.18378 ? 275 LYS   A CD  1 
ATOM   1509 C  CE  . LYS   A 1 275 ? -18.74100 -2.80571  -41.67552 1.000 28.93831 ? 275 LYS   A CE  1 
ATOM   1510 N  NZ  . LYS   A 1 275 ? -17.89923 -2.88155  -42.90210 1.000 38.24803 ? 275 LYS   A NZ  1 
ATOM   1511 N  N   . HIS   A 1 276 ? -18.61659 -7.08203  -36.11700 1.000 15.71194 ? 276 HIS   A N   1 
ATOM   1512 C  CA  . HIS   A 1 276 ? -17.89710 -7.68778  -34.99869 1.000 16.88804 ? 276 HIS   A CA  1 
ATOM   1513 C  C   . HIS   A 1 276 ? -17.44579 -9.10958  -35.31247 1.000 15.18158 ? 276 HIS   A C   1 
ATOM   1514 O  O   . HIS   A 1 276 ? -16.28772 -9.46917  -35.07027 1.000 16.91831 ? 276 HIS   A O   1 
ATOM   1515 C  CB  . HIS   A 1 276 ? -18.77221 -7.66819  -33.74588 1.000 14.59452 ? 276 HIS   A CB  1 
ATOM   1516 C  CG  . HIS   A 1 276 ? -18.34672 -8.64776  -32.69734 1.000 16.35803 ? 276 HIS   A CG  1 
ATOM   1517 N  ND1 . HIS   A 1 276 ? -17.33891 -8.38308  -31.79538 1.000 15.58789 ? 276 HIS   A ND1 1 
ATOM   1518 C  CD2 . HIS   A 1 276 ? -18.79437 -9.89216  -32.40641 1.000 17.47613 ? 276 HIS   A CD2 1 
ATOM   1519 C  CE1 . HIS   A 1 276 ? -17.18336 -9.42205  -30.99453 1.000 19.87212 ? 276 HIS   A CE1 1 
ATOM   1520 N  NE2 . HIS   A 1 276 ? -18.05452 -10.35131 -31.34392 1.000 15.39805 ? 276 HIS   A NE2 1 
ATOM   1521 N  N   . MET   A 1 277 ? -18.35132 -9.93942  -35.83695 1.000 19.72345 ? 277 MET   A N   1 
ATOM   1522 C  CA  . MET   A 1 277 ? -18.02643 -11.34747 -36.05384 1.000 22.17927 ? 277 MET   A CA  1 
ATOM   1523 C  C   . MET   A 1 277 ? -16.86167 -11.50439 -37.02491 1.000 15.94053 ? 277 MET   A C   1 
ATOM   1524 O  O   . MET   A 1 277 ? -15.91010 -12.24676 -36.75519 1.000 20.98242 ? 277 MET   A O   1 
ATOM   1525 C  CB  . MET   A 1 277 ? -19.25815 -12.10240 -36.55685 1.000 23.70001 ? 277 MET   A CB  1 
ATOM   1526 C  CG  . MET   A 1 277 ? -20.36122 -12.26075 -35.51782 1.000 29.00146 ? 277 MET   A CG  1 
ATOM   1527 S  SD  . MET   A 1 277 ? -19.79917 -13.08784 -34.01504 1.000 49.57597 ? 277 MET   A SD  1 
ATOM   1528 C  CE  . MET   A 1 277 ? -21.32567 -13.18424 -33.08147 1.000 33.29424 ? 277 MET   A CE  1 
ATOM   1529 N  N   . ASN   A 1 278 ? -16.91653 -10.80727 -38.16263 1.000 19.58959 ? 278 ASN   A N   1 
ATOM   1530 C  CA  . ASN   A 1 278 ? -15.81707 -10.88038 -39.12030 1.000 24.09218 ? 278 ASN   A CA  1 
ATOM   1531 C  C   . ASN   A 1 278 ? -14.54007 -10.28658 -38.54041 1.000 22.37935 ? 278 ASN   A C   1 
ATOM   1532 O  O   . ASN   A 1 278 ? -13.44688 -10.82545 -38.75103 1.000 20.97367 ? 278 ASN   A O   1 
ATOM   1533 C  CB  . ASN   A 1 278 ? -16.19751 -10.16995 -40.41865 1.000 24.87689 ? 278 ASN   A CB  1 
ATOM   1534 C  CG  . ASN   A 1 278 ? -17.27994 -10.90071 -41.18545 1.000 25.47413 ? 278 ASN   A CG  1 
ATOM   1535 O  OD1 . ASN   A 1 278 ? -17.65025 -12.02281 -40.84052 1.000 37.37890 ? 278 ASN   A OD1 1 
ATOM   1536 N  ND2 . ASN   A 1 278 ? -17.78624 -10.27215 -42.23965 1.000 32.04856 ? 278 ASN   A ND2 1 
ATOM   1537 N  N   . LEU   A 1 279 ? -14.66005 -9.17592  -37.81000 1.000 20.20793 ? 279 LEU   A N   1 
ATOM   1538 C  CA  . LEU   A 1 279 ? -13.50049 -8.58616  -37.14880 1.000 21.34122 ? 279 LEU   A CA  1 
ATOM   1539 C  C   . LEU   A 1 279 ? -12.88282 -9.56714  -36.15934 1.000 21.48826 ? 279 LEU   A C   1 
ATOM   1540 O  O   . LEU   A 1 279 ? -11.65911 -9.74117  -36.11725 1.000 19.94419 ? 279 LEU   A O   1 
ATOM   1541 C  CB  . LEU   A 1 279 ? -13.91189 -7.29164  -36.44522 1.000 21.02051 ? 279 LEU   A CB  1 
ATOM   1542 C  CG  . LEU   A 1 279 ? -12.87942 -6.17472  -36.28899 1.000 22.03668 ? 279 LEU   A CG  1 
ATOM   1543 C  CD1 . LEU   A 1 279 ? -12.36076 -5.72499  -37.64487 1.000 16.92548 ? 279 LEU   A CD1 1 
ATOM   1544 C  CD2 . LEU   A 1 279 ? -13.48754 -5.00334  -35.53110 1.000 26.17200 ? 279 LEU   A CD2 1 
ATOM   1545 N  N   . LEU   A 1 280 ? -13.72333 -10.22936 -35.36049 1.000 19.44066 ? 280 LEU   A N   1 
ATOM   1546 C  CA  . LEU   A 1 280 ? -13.22196 -11.19603 -34.38910 1.000 16.17380 ? 280 LEU   A CA  1 
ATOM   1547 C  C   . LEU   A 1 280 ? -12.62739 -12.41902 -35.07735 1.000 19.21096 ? 280 LEU   A C   1 
ATOM   1548 O  O   . LEU   A 1 280 ? -11.59341 -12.93978 -34.64179 1.000 18.19749 ? 280 LEU   A O   1 
ATOM   1549 C  CB  . LEU   A 1 280 ? -14.34368 -11.60706 -33.43622 1.000 14.43743 ? 280 LEU   A CB  1 
ATOM   1550 C  CG  . LEU   A 1 280 ? -13.99079 -12.65523 -32.37978 1.000 15.41604 ? 280 LEU   A CG  1 
ATOM   1551 C  CD1 . LEU   A 1 280 ? -12.80872 -12.19582 -31.53982 1.000 15.67146 ? 280 LEU   A CD1 1 
ATOM   1552 C  CD2 . LEU   A 1 280 ? -15.19425 -12.95640 -31.50035 1.000 14.49905 ? 280 LEU   A CD2 1 
ATOM   1553 N  N   . ALA   A 1 281 ? -13.26969 -12.89582 -36.14794 1.000 20.11157 ? 281 ALA   A N   1 
ATOM   1554 C  CA  . ALA   A 1 281 ? -12.72583 -14.02690 -36.89353 1.000 20.46694 ? 281 ALA   A CA  1 
ATOM   1555 C  C   . ALA   A 1 281 ? -11.34152 -13.70689 -37.44106 1.000 21.99765 ? 281 ALA   A C   1 
ATOM   1556 O  O   . ALA   A 1 281 ? -10.43990 -14.55288 -37.40649 1.000 25.95578 ? 281 ALA   A O   1 
ATOM   1557 C  CB  . ALA   A 1 281 ? -13.67467 -14.41723 -38.02691 1.000 21.07850 ? 281 ALA   A CB  1 
ATOM   1558 N  N   . ASP   A 1 282 ? -11.15424 -12.48460 -37.94575 1.000 24.46969 ? 282 ASP   A N   1 
ATOM   1559 C  CA  . ASP   A 1 282 ? -9.83973  -12.06730 -38.42213 1.000 21.41999 ? 282 ASP   A CA  1 
ATOM   1560 C  C   . ASP   A 1 282 ? -8.83650  -11.98915 -37.27950 1.000 23.65694 ? 282 ASP   A C   1 
ATOM   1561 O  O   . ASP   A 1 282 ? -7.66972  -12.36523 -37.44365 1.000 23.73601 ? 282 ASP   A O   1 
ATOM   1562 C  CB  . ASP   A 1 282 ? -9.94322  -10.71778 -39.13224 1.000 23.67487 ? 282 ASP   A CB  1 
ATOM   1563 C  CG  . ASP   A 1 282 ? -10.22865 -10.85673 -40.61318 1.000 29.49285 ? 282 ASP   A CG  1 
ATOM   1564 O  OD1 . ASP   A 1 282 ? -10.53842 -11.98115 -41.06014 1.000 32.65562 ? 282 ASP   A OD1 1 
ATOM   1565 O  OD2 . ASP   A 1 282 ? -10.14081 -9.83818  -41.33111 1.000 36.87304 ? 282 ASP   A OD2 1 
ATOM   1566 N  N   . LEU   A 1 283 ? -9.26902  -11.49449 -36.11730 1.000 19.88613 ? 283 LEU   A N   1 
ATOM   1567 C  CA  . LEU   A 1 283 ? -8.37005  -11.41155 -34.97182 1.000 19.39919 ? 283 LEU   A CA  1 
ATOM   1568 C  C   . LEU   A 1 283 ? -7.96064  -12.79898 -34.49547 1.000 22.99108 ? 283 LEU   A C   1 
ATOM   1569 O  O   . LEU   A 1 283 ? -6.79727  -13.01943 -34.13830 1.000 20.66360 ? 283 LEU   A O   1 
ATOM   1570 C  CB  . LEU   A 1 283 ? -9.03193  -10.62528 -33.84143 1.000 18.31938 ? 283 LEU   A CB  1 
ATOM   1571 C  CG  . LEU   A 1 283 ? -8.14455  -10.30954 -32.63752 1.000 16.49909 ? 283 LEU   A CG  1 
ATOM   1572 C  CD1 . LEU   A 1 283 ? -7.01499  -9.37818  -33.04511 1.000 17.24289 ? 283 LEU   A CD1 1 
ATOM   1573 C  CD2 . LEU   A 1 283 ? -8.96050  -9.70520  -31.50478 1.000 16.01403 ? 283 LEU   A CD2 1 
ATOM   1574 N  N   . LYS   A 1 284 ? -8.90508  -13.74404 -34.48023 1.000 20.74601 ? 284 LYS   A N   1 
ATOM   1575 C  CA  . LYS   A 1 284 ? -8.57211  -15.13102 -34.17069 1.000 23.41188 ? 284 LYS   A CA  1 
ATOM   1576 C  C   . LYS   A 1 284 ? -7.48774  -15.65376 -35.10217 1.000 19.78043 ? 284 LYS   A C   1 
ATOM   1577 O  O   . LYS   A 1 284 ? -6.47936  -16.21033 -34.65313 1.000 18.52039 ? 284 LYS   A O   1 
ATOM   1578 C  CB  . LYS   A 1 284 ? -9.81951  -16.00957 -34.27202 1.000 20.39696 ? 284 LYS   A CB  1 
ATOM   1579 C  CG  . LYS   A 1 284 ? -10.80547 -15.85500 -33.13462 1.000 26.68705 ? 284 LYS   A CG  1 
ATOM   1580 C  CD  . LYS   A 1 284 ? -11.65188 -17.11153 -33.00794 1.000 25.89040 ? 284 LYS   A CD  1 
ATOM   1581 C  CE  . LYS   A 1 284 ? -12.30579 -17.21431 -31.64155 1.000 30.47379 ? 284 LYS   A CE  1 
ATOM   1582 N  NZ  . LYS   A 1 284 ? -13.60243 -16.48800 -31.58417 1.000 41.75817 ? 284 LYS   A NZ  1 
ATOM   1583 N  N   . THR   A 1 285 ? -7.68593  -15.48135 -36.41205 1.000 22.90196 ? 285 THR   A N   1 
ATOM   1584 C  CA  . THR   A 1 285 ? -6.69787  -15.93999 -37.38294 1.000 20.28436 ? 285 THR   A CA  1 
ATOM   1585 C  C   . THR   A 1 285 ? -5.33188  -15.31383 -37.12399 1.000 26.19117 ? 285 THR   A C   1 
ATOM   1586 O  O   . THR   A 1 285 ? -4.30420  -15.99696 -37.20976 1.000 23.64147 ? 285 THR   A O   1 
ATOM   1587 C  CB  . THR   A 1 285 ? -7.17214  -15.62850 -38.80328 1.000 22.07680 ? 285 THR   A CB  1 
ATOM   1588 O  OG1 . THR   A 1 285 ? -8.35701  -16.38207 -39.09150 1.000 25.33062 ? 285 THR   A OG1 1 
ATOM   1589 C  CG2 . THR   A 1 285 ? -6.09675  -15.98840 -39.81415 1.000 19.78229 ? 285 THR   A CG2 1 
ATOM   1590 N  N   . MET   A 1 286 ? -5.29694  -14.01910 -36.79182 1.000 21.11227 ? 286 MET   A N   1 
ATOM   1591 C  CA  . MET   A 1 286 ? -4.01665  -13.37965 -36.50002 1.000 20.25467 ? 286 MET   A CA  1 
ATOM   1592 C  C   . MET   A 1 286 ? -3.35500  -13.99845 -35.27584 1.000 23.86458 ? 286 MET   A C   1 
ATOM   1593 O  O   . MET   A 1 286 ? -2.13910  -14.22052 -35.26673 1.000 22.23964 ? 286 MET   A O   1 
ATOM   1594 C  CB  . MET   A 1 286 ? -4.19069  -11.87401 -36.29738 1.000 20.74542 ? 286 MET   A CB  1 
ATOM   1595 C  CG  . MET   A 1 286 ? -2.94453  -11.21620 -35.70686 1.000 21.51031 ? 286 MET   A CG  1 
ATOM   1596 S  SD  . MET   A 1 286 ? -2.92667  -9.41582  -35.72472 1.000 22.97422 ? 286 MET   A SD  1 
ATOM   1597 C  CE  . MET   A 1 286 ? -3.25581  -9.07878  -37.44998 1.000 23.02718 ? 286 MET   A CE  1 
ATOM   1598 N  N   . VAL   A 1 287 ? -4.13646  -14.28148 -34.23102 1.000 23.59324 ? 287 VAL   A N   1 
ATOM   1599 C  CA  . VAL   A 1 287 ? -3.57152  -14.89282 -33.03043 1.000 24.77961 ? 287 VAL   A CA  1 
ATOM   1600 C  C   . VAL   A 1 287 ? -2.98060  -16.25815 -33.35601 1.000 21.49019 ? 287 VAL   A C   1 
ATOM   1601 O  O   . VAL   A 1 287 ? -1.88955  -16.60828 -32.88928 1.000 21.22205 ? 287 VAL   A O   1 
ATOM   1602 C  CB  . VAL   A 1 287 ? -4.63816  -14.98886 -31.92370 1.000 27.26670 ? 287 VAL   A CB  1 
ATOM   1603 C  CG1 . VAL   A 1 287 ? -4.12765  -15.83275 -30.76637 1.000 19.35924 ? 287 VAL   A CG1 1 
ATOM   1604 C  CG2 . VAL   A 1 287 ? -5.02413  -13.60324 -31.43851 1.000 26.06921 ? 287 VAL   A CG2 1 
ATOM   1605 N  N   . GLU   A 1 288 ? -3.68336  -17.04272 -34.17558 1.000 23.12093 ? 288 GLU   A N   1 
ATOM   1606 C  CA  . GLU   A 1 288 ? -3.23000  -18.39268 -34.49218 1.000 26.19973 ? 288 GLU   A CA  1 
ATOM   1607 C  C   . GLU   A 1 288 ? -1.96260  -18.38381 -35.34042 1.000 27.71584 ? 288 GLU   A C   1 
ATOM   1608 O  O   . GLU   A 1 288 ? -1.14923  -19.31021 -35.24516 1.000 21.77091 ? 288 GLU   A O   1 
ATOM   1609 C  CB  . GLU   A 1 288 ? -4.34850  -19.15585 -35.20325 1.000 22.60649 ? 288 GLU   A CB  1 
ATOM   1610 C  CG  . GLU   A 1 288 ? -4.02076  -20.60127 -35.53565 1.000 30.16292 ? 288 GLU   A CG  1 
ATOM   1611 C  CD  . GLU   A 1 288 ? -3.82613  -21.45819 -34.29958 1.000 34.03403 ? 288 GLU   A CD  1 
ATOM   1612 O  OE1 . GLU   A 1 288 ? -4.56582  -21.26190 -33.31226 1.000 36.04961 ? 288 GLU   A OE1 1 
ATOM   1613 O  OE2 . GLU   A 1 288 ? -2.93380  -22.33134 -34.31660 1.000 33.94867 ? 288 GLU   A OE2 1 
ATOM   1614 N  N   . THR   A 1 289 ? -1.77279  -17.35256 -36.16536 1.000 25.28549 ? 289 THR   A N   1 
ATOM   1615 C  CA  . THR   A 1 289 ? -0.60950  -17.23859 -37.03762 1.000 22.94664 ? 289 THR   A CA  1 
ATOM   1616 C  C   . THR   A 1 289 ? 0.35598   -16.15169 -36.57505 1.000 27.16430 ? 289 THR   A C   1 
ATOM   1617 O  O   . THR   A 1 289 ? 1.16859   -15.66897 -37.37059 1.000 22.36698 ? 289 THR   A O   1 
ATOM   1618 C  CB  . THR   A 1 289 ? -1.05334  -16.96750 -38.47599 1.000 24.15140 ? 289 THR   A CB  1 
ATOM   1619 O  OG1 . THR   A 1 289 ? -1.76346  -15.72353 -38.53174 1.000 24.56965 ? 289 THR   A OG1 1 
ATOM   1620 C  CG2 . THR   A 1 289 ? -1.96083  -18.08232 -38.97233 1.000 20.02342 ? 289 THR   A CG2 1 
ATOM   1621 N  N   . LYS   A 1 290 ? 0.29437   -15.77819 -35.29830 1.000 25.80549 ? 290 LYS   A N   1 
ATOM   1622 C  CA  . LYS   A 1 290 ? 0.98838   -14.59275 -34.81003 1.000 28.70726 ? 290 LYS   A CA  1 
ATOM   1623 C  C   . LYS   A 1 290 ? 2.50308   -14.73069 -34.92445 1.000 34.18877 ? 290 LYS   A C   1 
ATOM   1624 O  O   . LYS   A 1 290 ? 3.07311   -15.79289 -34.65966 1.000 34.03212 ? 290 LYS   A O   1 
ATOM   1625 C  CB  . LYS   A 1 290 ? 0.58427   -14.32564 -33.35629 1.000 29.15925 ? 290 LYS   A CB  1 
ATOM   1626 C  CG  . LYS   A 1 290 ? 1.68668   -13.76090 -32.47293 1.000 30.69829 ? 290 LYS   A CG  1 
ATOM   1627 C  CD  . LYS   A 1 290 ? 1.13515   -13.24991 -31.14854 1.000 33.23653 ? 290 LYS   A CD  1 
ATOM   1628 C  CE  . LYS   A 1 290 ? 0.70270   -14.38407 -30.23304 1.000 32.10295 ? 290 LYS   A CE  1 
ATOM   1629 N  NZ  . LYS   A 1 290 ? 0.42327   -13.89332 -28.85232 1.000 27.54482 ? 290 LYS   A NZ  1 
ATOM   1630 N  N   . LYS   A 1 291 ? 3.14874   -13.64058 -35.33643 1.000 31.37760 ? 291 LYS   A N   1 
ATOM   1631 C  CA  . LYS   A 1 291 ? 4.59913   -13.51724 -35.35667 1.000 33.04569 ? 291 LYS   A CA  1 
ATOM   1632 C  C   . LYS   A 1 291 ? 5.02862   -12.46059 -34.34759 1.000 31.83668 ? 291 LYS   A C   1 
ATOM   1633 O  O   . LYS   A 1 291 ? 4.34217   -11.45015 -34.16576 1.000 31.51825 ? 291 LYS   A O   1 
ATOM   1634 C  CB  . LYS   A 1 291 ? 5.10934   -13.12316 -36.74741 1.000 34.08777 ? 291 LYS   A CB  1 
ATOM   1635 C  CG  . LYS   A 1 291 ? 4.70826   -14.05039 -37.88227 1.000 35.22499 ? 291 LYS   A CG  1 
ATOM   1636 C  CD  . LYS   A 1 291 ? 5.25850   -15.44985 -37.68326 1.000 41.63963 ? 291 LYS   A CD  1 
ATOM   1637 C  CE  . LYS   A 1 291 ? 5.25617   -16.23006 -38.98746 1.000 37.58549 ? 291 LYS   A CE  1 
ATOM   1638 N  NZ  . LYS   A 1 291 ? 6.23865   -15.67188 -39.96210 1.000 34.32259 ? 291 LYS   A NZ  1 
ATOM   1639 N  N   . VAL   A 1 292 ? 6.16543   -12.69282 -33.69350 1.000 35.29020 ? 292 VAL   A N   1 
ATOM   1640 C  CA  . VAL   A 1 292 ? 6.75010   -11.71425 -32.78787 1.000 35.33789 ? 292 VAL   A CA  1 
ATOM   1641 C  C   . VAL   A 1 292 ? 8.16909   -11.41191 -33.25034 1.000 39.19628 ? 292 VAL   A C   1 
ATOM   1642 O  O   . VAL   A 1 292 ? 8.76586   -12.14912 -34.03907 1.000 41.08629 ? 292 VAL   A O   1 
ATOM   1643 C  CB  . VAL   A 1 292 ? 6.74868   -12.18417 -31.31684 1.000 34.73885 ? 292 VAL   A CB  1 
ATOM   1644 C  CG1 . VAL   A 1 292 ? 5.34348   -12.57124 -30.87542 1.000 30.46827 ? 292 VAL   A CG1 1 
ATOM   1645 C  CG2 . VAL   A 1 292 ? 7.72310   -13.33557 -31.12006 1.000 38.30827 ? 292 VAL   A CG2 1 
ATOM   1646 N  N   . THR   A 1 293 ? 8.70414   -10.30105 -32.75159 1.000 38.20779 ? 293 THR   A N   1 
ATOM   1647 C  CA  . THR   A 1 293 ? 10.07377  -9.91245  -33.03872 1.000 40.88772 ? 293 THR   A CA  1 
ATOM   1648 C  C   . THR   A 1 293 ? 11.01920  -10.57169 -32.03701 1.000 42.12114 ? 293 THR   A C   1 
ATOM   1649 O  O   . THR   A 1 293 ? 10.60149  -11.30186 -31.13471 1.000 40.53130 ? 293 THR   A O   1 
ATOM   1650 C  CB  . THR   A 1 293 ? 10.21950  -8.39195  -33.00561 1.000 36.94193 ? 293 THR   A CB  1 
ATOM   1651 O  OG1 . THR   A 1 293 ? 10.01996  -7.92138  -31.66670 1.000 43.04863 ? 293 THR   A OG1 1 
ATOM   1652 C  CG2 . THR   A 1 293 ? 9.19617   -7.74053  -33.92123 1.000 34.64564 ? 293 THR   A CG2 1 
ATOM   1653 N  N   . SER   A 1 294 ? 12.31878  -10.30816 -32.19461 1.000 44.82123 ? 294 SER   A N   1 
ATOM   1654 C  CA  . SER   A 1 294 ? 13.29649  -10.83296 -31.24909 1.000 44.65563 ? 294 SER   A CA  1 
ATOM   1655 C  C   . SER   A 1 294 ? 13.13764  -10.22625 -29.86122 1.000 46.81885 ? 294 SER   A C   1 
ATOM   1656 O  O   . SER   A 1 294 ? 13.63240  -10.80241 -28.88678 1.000 54.03879 ? 294 SER   A O   1 
ATOM   1657 C  CB  . SER   A 1 294 ? 14.71600  -10.59685 -31.76835 1.000 41.61524 ? 294 SER   A CB  1 
ATOM   1658 O  OG  . SER   A 1 294 ? 14.94365  -9.22520  -32.03846 1.000 44.03118 ? 294 SER   A OG  1 
ATOM   1659 N  N   . SER   A 1 295 ? 12.46022  -9.08592  -29.74813 1.000 40.39348 ? 295 SER   A N   1 
ATOM   1660 C  CA  . SER   A 1 295 ? 12.16253  -8.47966  -28.45895 1.000 42.92776 ? 295 SER   A CA  1 
ATOM   1661 C  C   . SER   A 1 295 ? 10.81747  -8.92795  -27.89675 1.000 43.75559 ? 295 SER   A C   1 
ATOM   1662 O  O   . SER   A 1 295 ? 10.29834  -8.28509  -26.97828 1.000 48.18680 ? 295 SER   A O   1 
ATOM   1663 C  CB  . SER   A 1 295 ? 12.20212  -6.95272  -28.57204 1.000 45.63691 ? 295 SER   A CB  1 
ATOM   1664 O  OG  . SER   A 1 295 ? 11.20867  -6.47693  -29.46365 1.000 47.82160 ? 295 SER   A OG  1 
ATOM   1665 N  N   . GLY   A 1 296 ? 10.24572  -10.01052 -28.42568 1.000 41.05255 ? 296 GLY   A N   1 
ATOM   1666 C  CA  . GLY   A 1 296 ? 8.98251   -10.52965 -27.93730 1.000 38.87635 ? 296 GLY   A CA  1 
ATOM   1667 C  C   . GLY   A 1 296 ? 7.77556   -9.67286  -28.23636 1.000 39.00649 ? 296 GLY   A C   1 
ATOM   1668 O  O   . GLY   A 1 296 ? 6.69377   -9.94062  -27.70543 1.000 31.23383 ? 296 GLY   A O   1 
ATOM   1669 N  N   . VAL   A 1 297 ? 7.92519   -8.66113  -29.07270 1.000 35.09069 ? 297 VAL   A N   1 
ATOM   1670 C  CA  . VAL   A 1 297 ? 6.86679   -7.71211  -29.38542 1.000 33.22593 ? 297 VAL   A CA  1 
ATOM   1671 C  C   . VAL   A 1 297 ? 6.17998   -8.13787  -30.67702 1.000 34.78299 ? 297 VAL   A C   1 
ATOM   1672 O  O   . VAL   A 1 297 ? 6.81006   -8.69782  -31.58206 1.000 33.06742 ? 297 VAL   A O   1 
ATOM   1673 C  CB  . VAL   A 1 297 ? 7.46235   -6.28910  -29.47147 1.000 35.91568 ? 297 VAL   A CB  1 
ATOM   1674 C  CG1 . VAL   A 1 297 ? 6.93844   -5.54193  -30.67017 1.000 32.96628 ? 297 VAL   A CG1 1 
ATOM   1675 C  CG2 . VAL   A 1 297 ? 7.18805   -5.51996  -28.18349 1.000 29.92573 ? 297 VAL   A CG2 1 
ATOM   1676 N  N   . LEU   A 1 298 ? 4.86987   -7.89108  -30.75476 1.000 32.00415 ? 298 LEU   A N   1 
ATOM   1677 C  CA  . LEU   A 1 298 ? 4.08872   -8.29740  -31.91824 1.000 27.70368 ? 298 LEU   A CA  1 
ATOM   1678 C  C   . LEU   A 1 298 ? 4.67508   -7.71983  -33.20283 1.000 27.12081 ? 298 LEU   A C   1 
ATOM   1679 O  O   . LEU   A 1 298 ? 5.08438   -6.55621  -33.25335 1.000 28.94021 ? 298 LEU   A O   1 
ATOM   1680 C  CB  . LEU   A 1 298 ? 2.63364   -7.85058  -31.75663 1.000 28.66168 ? 298 LEU   A CB  1 
ATOM   1681 C  CG  . LEU   A 1 298 ? 1.59982   -8.42646  -32.72692 1.000 34.71918 ? 298 LEU   A CG  1 
ATOM   1682 C  CD1 . LEU   A 1 298 ? 1.45246   -9.92454  -32.52720 1.000 35.43885 ? 298 LEU   A CD1 1 
ATOM   1683 C  CD2 . LEU   A 1 298 ? 0.25907   -7.72993  -32.55755 1.000 29.11620 ? 298 LEU   A CD2 1 
ATOM   1684 N  N   . LEU   A 1 299 ? 4.71685   -8.54851  -34.24528 1.000 24.27826 ? 299 LEU   A N   1 
ATOM   1685 C  CA  . LEU   A 1 299 ? 5.28031   -8.17345  -35.53724 1.000 23.94334 ? 299 LEU   A CA  1 
ATOM   1686 C  C   . LEU   A 1 299 ? 4.14702   -7.90800  -36.52103 1.000 26.82656 ? 299 LEU   A C   1 
ATOM   1687 O  O   . LEU   A 1 299 ? 3.39628   -8.82492  -36.87145 1.000 25.11853 ? 299 LEU   A O   1 
ATOM   1688 C  CB  . LEU   A 1 299 ? 6.20820   -9.27012  -36.06214 1.000 30.48151 ? 299 LEU   A CB  1 
ATOM   1689 C  CG  . LEU   A 1 299 ? 6.60003   -9.24401  -37.54184 1.000 32.00348 ? 299 LEU   A CG  1 
ATOM   1690 C  CD1 . LEU   A 1 299 ? 7.31674   -7.94485  -37.91270 1.000 30.50455 ? 299 LEU   A CD1 1 
ATOM   1691 C  CD2 . LEU   A 1 299 ? 7.46560   -10.45798 -37.87588 1.000 39.20748 ? 299 LEU   A CD2 1 
ATOM   1692 N  N   . LEU   A 1 300 ? 4.03043   -6.65971  -36.96982 1.000 25.82710 ? 300 LEU   A N   1 
ATOM   1693 C  CA  . LEU   A 1 300 ? 2.96401   -6.24368  -37.87606 1.000 26.61768 ? 300 LEU   A CA  1 
ATOM   1694 C  C   . LEU   A 1 300 ? 3.59363   -5.73418  -39.16806 1.000 30.92590 ? 300 LEU   A C   1 
ATOM   1695 O  O   . LEU   A 1 300 ? 4.15129   -4.63167  -39.20445 1.000 32.24557 ? 300 LEU   A O   1 
ATOM   1696 C  CB  . LEU   A 1 300 ? 2.07255   -5.19152  -37.21861 1.000 25.02729 ? 300 LEU   A CB  1 
ATOM   1697 C  CG  . LEU   A 1 300 ? 1.33105   -5.69184  -35.97269 1.000 23.76507 ? 300 LEU   A CG  1 
ATOM   1698 C  CD1 . LEU   A 1 300 ? 0.28017   -4.69156  -35.51993 1.000 21.41878 ? 300 LEU   A CD1 1 
ATOM   1699 C  CD2 . LEU   A 1 300 ? 0.70064   -7.05823  -36.21644 1.000 20.92222 ? 300 LEU   A CD2 1 
ATOM   1700 N  N   . ASP   A 1 301 ? 3.46929   -6.53559  -40.23005 1.000 30.85934 ? 301 ASP   A N   1 
ATOM   1701 C  CA  . ASP   A 1 301 ? 4.25794   -6.39593  -41.44955 1.000 31.54166 ? 301 ASP   A CA  1 
ATOM   1702 C  C   . ASP   A 1 301 ? 3.72495   -5.34340  -42.41134 1.000 32.77874 ? 301 ASP   A C   1 
ATOM   1703 O  O   . ASP   A 1 301 ? 4.48372   -4.85912  -43.25858 1.000 26.20896 ? 301 ASP   A O   1 
ATOM   1704 C  CB  . ASP   A 1 301 ? 4.29810   -7.74211  -42.18112 1.000 24.17057 ? 301 ASP   A CB  1 
ATOM   1705 C  CG  . ASP   A 1 301 ? 5.68743   -8.12863  -42.63279 1.000 34.23435 ? 301 ASP   A CG  1 
ATOM   1706 O  OD1 . ASP   A 1 301 ? 6.12562   -7.63343  -43.69175 1.000 48.31508 ? 301 ASP   A OD1 1 
ATOM   1707 O  OD2 . ASP   A 1 301 ? 6.33087   -8.94798  -41.94271 1.000 40.08387 ? 301 ASP   A OD2 1 
ATOM   1708 N  N   . ASN   A 1 302 ? 2.45070   -4.98357  -42.30607 1.000 26.56942 ? 302 ASN   A N   1 
ATOM   1709 C  CA  . ASN   A 1 302 ? 1.74273   -4.36089  -43.41473 1.000 24.84891 ? 302 ASN   A CA  1 
ATOM   1710 C  C   . ASN   A 1 302 ? 0.53293   -3.62240  -42.86543 1.000 25.54756 ? 302 ASN   A C   1 
ATOM   1711 O  O   . ASN   A 1 302 ? 0.13363   -3.82125  -41.71688 1.000 21.47916 ? 302 ASN   A O   1 
ATOM   1712 C  CB  . ASN   A 1 302 ? 1.32316   -5.42046  -44.43451 1.000 25.51713 ? 302 ASN   A CB  1 
ATOM   1713 C  CG  . ASN   A 1 302 ? 0.51739   -6.54229  -43.79790 1.000 27.34011 ? 302 ASN   A CG  1 
ATOM   1714 O  OD1 . ASN   A 1 302 ? -0.68082  -6.39935  -43.55441 1.000 25.15184 ? 302 ASN   A OD1 1 
ATOM   1715 N  ND2 . ASN   A 1 302 ? 1.18037   -7.65568  -43.50119 1.000 30.23944 ? 302 ASN   A ND2 1 
ATOM   1716 N  N   . TYR   A 1 303 ? -0.06436  -2.77960  -43.71172 1.000 21.46369 ? 303 TYR   A N   1 
ATOM   1717 C  CA  . TYR   A 1 303 ? -1.20296  -1.98296  -43.26522 1.000 22.56098 ? 303 TYR   A CA  1 
ATOM   1718 C  C   . TYR   A 1 303 ? -2.34770  -2.86833  -42.78680 1.000 22.65491 ? 303 TYR   A C   1 
ATOM   1719 O  O   . TYR   A 1 303 ? -2.93476  -2.61868  -41.72783 1.000 25.09435 ? 303 TYR   A O   1 
ATOM   1720 C  CB  . TYR   A 1 303 ? -1.68495  -1.05586  -44.37865 1.000 20.83106 ? 303 TYR   A CB  1 
ATOM   1721 C  CG  . TYR   A 1 303 ? -2.80136  -0.15644  -43.90930 1.000 22.06483 ? 303 TYR   A CG  1 
ATOM   1722 C  CD1 . TYR   A 1 303 ? -2.54383  0.89246   -43.03729 1.000 24.71757 ? 303 TYR   A CD1 1 
ATOM   1723 C  CD2 . TYR   A 1 303 ? -4.11338  -0.37312  -44.30892 1.000 20.12984 ? 303 TYR   A CD2 1 
ATOM   1724 C  CE1 . TYR   A 1 303 ? -3.55563  1.71243   -42.59076 1.000 18.01160 ? 303 TYR   A CE1 1 
ATOM   1725 C  CE2 . TYR   A 1 303 ? -5.13487  0.44340   -43.86713 1.000 18.07603 ? 303 TYR   A CE2 1 
ATOM   1726 C  CZ  . TYR   A 1 303 ? -4.84852  1.48480   -43.00795 1.000 18.05183 ? 303 TYR   A CZ  1 
ATOM   1727 O  OH  . TYR   A 1 303 ? -5.85689  2.30495   -42.56151 1.000 16.91131 ? 303 TYR   A OH  1 
ATOM   1728 N  N   . SER   A 1 304 ? -2.67360  -3.91345  -43.55594 1.000 18.40768 ? 304 SER   A N   1 
ATOM   1729 C  CA  . SER   A 1 304 ? -3.82053  -4.76063  -43.23410 1.000 22.39939 ? 304 SER   A CA  1 
ATOM   1730 C  C   . SER   A 1 304 ? -3.74982  -5.29143  -41.80702 1.000 22.58546 ? 304 SER   A C   1 
ATOM   1731 O  O   . SER   A 1 304 ? -4.74772  -5.26657  -41.07759 1.000 20.36413 ? 304 SER   A O   1 
ATOM   1732 C  CB  . SER   A 1 304 ? -3.91178  -5.91902  -44.22985 1.000 20.37608 ? 304 SER   A CB  1 
ATOM   1733 O  OG  . SER   A 1 304 ? -5.01798  -6.75847  -43.94211 1.000 33.89615 ? 304 SER   A OG  1 
ATOM   1734 N  N   . ASP   A 1 305 ? -2.57416  -5.76154  -41.38516 1.000 16.02517 ? 305 ASP   A N   1 
ATOM   1735 C  CA  . ASP   A 1 305 ? -2.42613  -6.28354  -40.03071 1.000 17.47086 ? 305 ASP   A CA  1 
ATOM   1736 C  C   . ASP   A 1 305 ? -2.37816  -5.16686  -38.99542 1.000 17.18494 ? 305 ASP   A C   1 
ATOM   1737 O  O   . ASP   A 1 305 ? -2.93020  -5.31207  -37.89902 1.000 13.94364 ? 305 ASP   A O   1 
ATOM   1738 C  CB  . ASP   A 1 305 ? -1.17039  -7.14915  -39.93486 1.000 21.51643 ? 305 ASP   A CB  1 
ATOM   1739 C  CG  . ASP   A 1 305 ? -1.33568  -8.48549  -40.62427 1.000 22.33019 ? 305 ASP   A CG  1 
ATOM   1740 O  OD1 . ASP   A 1 305 ? -2.49322  -8.89501  -40.85236 1.000 22.48490 ? 305 ASP   A OD1 1 
ATOM   1741 O  OD2 . ASP   A 1 305 ? -0.31255  -9.12830  -40.93477 1.000 21.52649 ? 305 ASP   A OD2 1 
ATOM   1742 N  N   . ARG   A 1 306 ? -1.72574  -4.04948  -39.32159 1.000 13.53359 ? 306 ARG   A N   1 
ATOM   1743 C  CA  . ARG   A 1 306 ? -1.62293  -2.95039  -38.36666 1.000 16.78075 ? 306 ARG   A CA  1 
ATOM   1744 C  C   . ARG   A 1 306 ? -2.98551  -2.32458  -38.10107 1.000 15.03647 ? 306 ARG   A C   1 
ATOM   1745 O  O   . ARG   A 1 306 ? -3.37156  -2.11772  -36.94450 1.000 14.58230 ? 306 ARG   A O   1 
ATOM   1746 C  CB  . ARG   A 1 306 ? -0.63510  -1.90163  -38.87676 1.000 18.00868 ? 306 ARG   A CB  1 
ATOM   1747 C  CG  . ARG   A 1 306 ? 0.76536   -2.44503  -39.07333 1.000 18.24781 ? 306 ARG   A CG  1 
ATOM   1748 C  CD  . ARG   A 1 306 ? 1.66918   -1.45667  -39.78403 1.000 20.19892 ? 306 ARG   A CD  1 
ATOM   1749 N  NE  . ARG   A 1 306 ? 2.10871   -0.38090  -38.90232 1.000 19.87915 ? 306 ARG   A NE  1 
ATOM   1750 C  CZ  . ARG   A 1 306 ? 3.13535   -0.47643  -38.06336 1.000 22.30470 ? 306 ARG   A CZ  1 
ATOM   1751 N  NH1 . ARG   A 1 306 ? 3.82973   -1.60477  -37.98304 1.000 19.04128 ? 306 ARG   A NH1 1 
ATOM   1752 N  NH2 . ARG   A 1 306 ? 3.46606   0.55601   -37.30117 1.000 17.90372 ? 306 ARG   A NH2 1 
ATOM   1753 N  N   . ILE   A 1 307 ? -3.73448  -2.02192  -39.16433 1.000 15.69564 ? 307 ILE   A N   1 
ATOM   1754 C  CA  . ILE   A 1 307 ? -5.03918  -1.39784  -38.97819 1.000 16.74805 ? 307 ILE   A CA  1 
ATOM   1755 C  C   . ILE   A 1 307 ? -6.00086  -2.35421  -38.28449 1.000 16.21212 ? 307 ILE   A C   1 
ATOM   1756 O  O   . ILE   A 1 307 ? -6.84288  -1.92391  -37.48763 1.000 12.32605 ? 307 ILE   A O   1 
ATOM   1757 C  CB  . ILE   A 1 307 ? -5.60384  -0.89597  -40.32243 1.000 14.40139 ? 307 ILE   A CB  1 
ATOM   1758 C  CG1 . ILE   A 1 307 ? -6.78689  0.03726   -40.07550 1.000 14.57590 ? 307 ILE   A CG1 1 
ATOM   1759 C  CG2 . ILE   A 1 307 ? -6.03001  -2.04894  -41.21695 1.000 14.13625 ? 307 ILE   A CG2 1 
ATOM   1760 C  CD1 . ILE   A 1 307 ? -6.41117  1.29663   -39.33220 1.000 15.39392 ? 307 ILE   A CD1 1 
ATOM   1761 N  N   . GLN   A 1 308 ? -5.87660  -3.66080  -38.54220 1.000 15.56926 ? 308 GLN   A N   1 
ATOM   1762 C  CA  . GLN   A 1 308 ? -6.78198  -4.62925  -37.92827 1.000 15.01263 ? 308 GLN   A CA  1 
ATOM   1763 C  C   . GLN   A 1 308 ? -6.55103  -4.72719  -36.42659 1.000 12.34551 ? 308 GLN   A C   1 
ATOM   1764 O  O   . GLN   A 1 308 ? -7.50195  -4.91896  -35.65949 1.000 14.12672 ? 308 GLN   A O   1 
ATOM   1765 C  CB  . GLN   A 1 308 ? -6.62113  -5.99797  -38.59568 1.000 21.95787 ? 308 GLN   A CB  1 
ATOM   1766 C  CG  . GLN   A 1 308 ? -6.79131  -7.21204  -37.68283 1.000 25.99890 ? 308 GLN   A CG  1 
ATOM   1767 C  CD  . GLN   A 1 308 ? -6.47410  -8.50296  -38.40558 1.000 34.46242 ? 308 GLN   A CD  1 
ATOM   1768 O  OE1 . GLN   A 1 308 ? -5.84133  -8.49065  -39.46350 1.000 30.68201 ? 308 GLN   A OE1 1 
ATOM   1769 N  NE2 . GLN   A 1 308 ? -6.90713  -9.62343  -37.83870 1.000 36.34464 ? 308 GLN   A NE2 1 
ATOM   1770 N  N   . VAL   A 1 309 ? -5.29682  -4.59905  -35.98731 1.000 11.50646 ? 309 VAL   A N   1 
ATOM   1771 C  CA  . VAL   A 1 309 ? -5.02095  -4.55135  -34.55452 1.000 13.91930 ? 309 VAL   A CA  1 
ATOM   1772 C  C   . VAL   A 1 309 ? -5.58539  -3.27364  -33.94752 1.000 11.66756 ? 309 VAL   A C   1 
ATOM   1773 O  O   . VAL   A 1 309 ? -6.17878  -3.29497  -32.86256 1.000 12.92566 ? 309 VAL   A O   1 
ATOM   1774 C  CB  . VAL   A 1 309 ? -3.50984  -4.68439  -34.29094 1.000 11.75632 ? 309 VAL   A CB  1 
ATOM   1775 C  CG1 . VAL   A 1 309 ? -3.19710  -4.43763  -32.82109 1.000 11.92480 ? 309 VAL   A CG1 1 
ATOM   1776 C  CG2 . VAL   A 1 309 ? -3.02513  -6.05915  -34.70195 1.000 13.36111 ? 309 VAL   A CG2 1 
ATOM   1777 N  N   . LEU   A 1 310 ? -5.41928  -2.14353  -34.63823 1.000 9.38779  ? 310 LEU   A N   1 
ATOM   1778 C  CA  . LEU   A 1 310 ? -5.97053  -0.88663  -34.14167 1.000 9.51672  ? 310 LEU   A CA  1 
ATOM   1779 C  C   . LEU   A 1 310 ? -7.49400  -0.90168  -34.16868 1.000 10.49264 ? 310 LEU   A C   1 
ATOM   1780 O  O   . LEU   A 1 310 ? -8.14138  -0.34013  -33.27640 1.000 11.56885 ? 310 LEU   A O   1 
ATOM   1781 C  CB  . LEU   A 1 310 ? -5.43053  0.28358   -34.96236 1.000 9.99171  ? 310 LEU   A CB  1 
ATOM   1782 C  CG  . LEU   A 1 310 ? -3.92028  0.52317   -34.90047 1.000 12.25943 ? 310 LEU   A CG  1 
ATOM   1783 C  CD1 . LEU   A 1 310 ? -3.51165  1.59390   -35.90087 1.000 13.82337 ? 310 LEU   A CD1 1 
ATOM   1784 C  CD2 . LEU   A 1 310 ? -3.49359  0.90894   -33.48993 1.000 11.63070 ? 310 LEU   A CD2 1 
ATOM   1785 N  N   . GLN   A 1 311 ? -8.08243  -1.53304  -35.18815 1.000 9.49809  ? 311 GLN   A N   1 
ATOM   1786 C  CA  . GLN   A 1 311 ? -9.53506  -1.66998  -35.24307 1.000 10.75272 ? 311 GLN   A CA  1 
ATOM   1787 C  C   . GLN   A 1 311 ? -10.05369 -2.46389  -34.05164 1.000 10.26741 ? 311 GLN   A C   1 
ATOM   1788 O  O   . GLN   A 1 311 ? -10.97283 -2.02634  -33.35009 1.000 11.21801 ? 311 GLN   A O   1 
ATOM   1789 C  CB  . GLN   A 1 311 ? -9.95206  -2.34341  -36.55117 1.000 11.71692 ? 311 GLN   A CB  1 
ATOM   1790 C  CG  . GLN   A 1 311 ? -9.86157  -1.46073  -37.78373 1.000 11.39195 ? 311 GLN   A CG  1 
ATOM   1791 C  CD  . GLN   A 1 311 ? -10.09131 -2.23964  -39.06534 1.000 16.39257 ? 311 GLN   A CD  1 
ATOM   1792 O  OE1 . GLN   A 1 311 ? -9.59445  -3.35554  -39.22366 1.000 13.25327 ? 311 GLN   A OE1 1 
ATOM   1793 N  NE2 . GLN   A 1 311 ? -10.84936 -1.65604  -39.98654 1.000 11.16430 ? 311 GLN   A NE2 1 
ATOM   1794 N  N   . ASN   A 1 312 ? -9.47158  -3.64104  -33.80809 1.000 13.16618 ? 312 ASN   A N   1 
ATOM   1795 C  CA  . ASN   A 1 312 ? -9.91501  -4.46819  -32.69147 1.000 11.62023 ? 312 ASN   A CA  1 
ATOM   1796 C  C   . ASN   A 1 312 ? -9.56586  -3.84170  -31.34787 1.000 10.44946 ? 312 ASN   A C   1 
ATOM   1797 O  O   . ASN   A 1 312 ? -10.29316 -4.04356  -30.36881 1.000 8.68477  ? 312 ASN   A O   1 
ATOM   1798 C  CB  . ASN   A 1 312 ? -9.30924  -5.86830  -32.79595 1.000 13.30403 ? 312 ASN   A CB  1 
ATOM   1799 C  CG  . ASN   A 1 312 ? -10.02503 -6.73808  -33.81101 1.000 17.26370 ? 312 ASN   A CG  1 
ATOM   1800 O  OD1 . ASN   A 1 312 ? -11.12005 -7.23823  -33.55393 1.000 18.42948 ? 312 ASN   A OD1 1 
ATOM   1801 N  ND2 . ASN   A 1 312 ? -9.40917  -6.92174  -34.97305 1.000 17.65950 ? 312 ASN   A ND2 1 
ATOM   1802 N  N   . MET   A 1 313 ? -8.46415  -3.08940  -31.27537 1.000 9.60398  ? 313 MET   A N   1 
ATOM   1803 C  CA  . MET   A 1 313 ? -8.10683  -2.42517  -30.02476 1.000 11.91208 ? 313 MET   A CA  1 
ATOM   1804 C  C   . MET   A 1 313 ? -9.17927  -1.42557  -29.61214 1.000 9.86599  ? 313 MET   A C   1 
ATOM   1805 O  O   . MET   A 1 313 ? -9.66275  -1.44829  -28.47447 1.000 11.34813 ? 313 MET   A O   1 
ATOM   1806 C  CB  . MET   A 1 313 ? -6.75570  -1.72301  -30.15893 1.000 10.05491 ? 313 MET   A CB  1 
ATOM   1807 C  CG  . MET   A 1 313 ? -6.33104  -0.99288  -28.89304 1.000 12.61207 ? 313 MET   A CG  1 
ATOM   1808 S  SD  . MET   A 1 313 ? -4.88164  0.05310   -29.11288 1.000 12.36116 ? 313 MET   A SD  1 
ATOM   1809 C  CE  . MET   A 1 313 ? -3.66325  -1.15774  -29.60867 1.000 11.63866 ? 313 MET   A CE  1 
ATOM   1810 N  N   . VAL   A 1 314 ? -9.55748  -0.53197  -30.52897 1.000 9.18925  ? 314 VAL   A N   1 
ATOM   1811 C  CA  . VAL   A 1 314 ? -10.59415 0.45305   -30.23569 1.000 10.44761 ? 314 VAL   A CA  1 
ATOM   1812 C  C   . VAL   A 1 314 ? -11.93901 -0.23353  -30.03038 1.000 8.51557  ? 314 VAL   A C   1 
ATOM   1813 O  O   . VAL   A 1 314 ? -12.75342 0.19486   -29.20298 1.000 8.56536  ? 314 VAL   A O   1 
ATOM   1814 C  CB  . VAL   A 1 314 ? -10.64891 1.50340   -31.36010 1.000 7.07629  ? 314 VAL   A CB  1 
ATOM   1815 C  CG1 . VAL   A 1 314 ? -11.78404 2.48835   -31.12804 1.000 11.61501 ? 314 VAL   A CG1 1 
ATOM   1816 C  CG2 . VAL   A 1 314 ? -9.31565  2.23376   -31.45832 1.000 6.31727  ? 314 VAL   A CG2 1 
ATOM   1817 N  N   . HIS   A 1 315 ? -12.18753 -1.31247  -30.77651 1.000 9.80350  ? 315 HIS   A N   1 
ATOM   1818 C  CA  . HIS   A 1 315 ? -13.39763 -2.10488  -30.58298 1.000 9.80164  ? 315 HIS   A CA  1 
ATOM   1819 C  C   . HIS   A 1 315 ? -13.42638 -2.72670  -29.19063 1.000 12.75266 ? 315 HIS   A C   1 
ATOM   1820 O  O   . HIS   A 1 315 ? -14.47611 -2.75721  -28.53599 1.000 11.15604 ? 315 HIS   A O   1 
ATOM   1821 C  CB  . HIS   A 1 315 ? -13.47376 -3.17567  -31.67459 1.000 11.04018 ? 315 HIS   A CB  1 
ATOM   1822 C  CG  . HIS   A 1 315 ? -14.69197 -4.04359  -31.60935 1.000 11.64527 ? 315 HIS   A CG  1 
ATOM   1823 N  ND1 . HIS   A 1 315 ? -15.96715 -3.53483  -31.48534 1.000 14.08604 ? 315 HIS   A ND1 1 
ATOM   1824 C  CD2 . HIS   A 1 315 ? -14.82994 -5.38818  -31.69350 1.000 11.58143 ? 315 HIS   A CD2 1 
ATOM   1825 C  CE1 . HIS   A 1 315 ? -16.83611 -4.52997  -31.47392 1.000 14.16985 ? 315 HIS   A CE1 1 
ATOM   1826 N  NE2 . HIS   A 1 315 ? -16.17171 -5.66486  -31.59803 1.000 12.07514 ? 315 HIS   A NE2 1 
ATOM   1827 N  N   . CYS   A 1 316 ? -12.27595 -3.21649  -28.71638 1.000 9.76787  ? 316 CYS   A N   1 
ATOM   1828 C  CA  . CYS   A 1 316 ? -12.19199 -3.73287  -27.35274 1.000 8.98461  ? 316 CYS   A CA  1 
ATOM   1829 C  C   . CYS   A 1 316 ? -12.44658 -2.63340  -26.33005 1.000 9.68485  ? 316 CYS   A C   1 
ATOM   1830 O  O   . CYS   A 1 316 ? -13.15915 -2.84786  -25.34204 1.000 9.01917  ? 316 CYS   A O   1 
ATOM   1831 C  CB  . CYS   A 1 316 ? -10.82338 -4.37221  -27.10897 1.000 13.29067 ? 316 CYS   A CB  1 
ATOM   1832 S  SG  . CYS   A 1 316 ? -10.59134 -6.00879  -27.84193 1.000 13.02941 ? 316 CYS   A SG  1 
ATOM   1833 N  N   . ALA   A 1 317 ? -11.85688 -1.45272  -26.54160 1.000 7.86602  ? 317 ALA   A N   1 
ATOM   1834 C  CA  . ALA   A 1 317 ? -12.10931 -0.32732  -25.64724 1.000 10.92927 ? 317 ALA   A CA  1 
ATOM   1835 C  C   . ALA   A 1 317 ? -13.58122 0.05922   -25.66183 1.000 7.80579  ? 317 ALA   A C   1 
ATOM   1836 O  O   . ALA   A 1 317 ? -14.14541 0.43487   -24.62777 1.000 9.53427  ? 317 ALA   A O   1 
ATOM   1837 C  CB  . ALA   A 1 317 ? -11.23725 0.86488   -26.04252 1.000 8.18730  ? 317 ALA   A CB  1 
ATOM   1838 N  N   . ASP   A 1 318 ? -14.21881 -0.03460  -26.83016 1.000 8.18343  ? 318 ASP   A N   1 
ATOM   1839 C  CA  . ASP   A 1 318 ? -15.64707 0.23584   -26.93754 1.000 8.73626  ? 318 ASP   A CA  1 
ATOM   1840 C  C   . ASP   A 1 318 ? -16.47002 -0.77518  -26.14749 1.000 11.59983 ? 318 ASP   A C   1 
ATOM   1841 O  O   . ASP   A 1 318 ? -17.51839 -0.42397  -25.59361 1.000 10.82121 ? 318 ASP   A O   1 
ATOM   1842 C  CB  . ASP   A 1 318 ? -16.05571 0.22762   -28.41141 1.000 11.24809 ? 318 ASP   A CB  1 
ATOM   1843 C  CG  . ASP   A 1 318 ? -17.36672 0.93817   -28.66004 1.000 10.95992 ? 318 ASP   A CG  1 
ATOM   1844 O  OD1 . ASP   A 1 318 ? -17.67894 1.88021   -27.90538 1.000 8.11691  ? 318 ASP   A OD1 1 
ATOM   1845 O  OD2 . ASP   A 1 318 ? -18.07722 0.56265   -29.61710 1.000 10.93861 ? 318 ASP   A OD2 1 
ATOM   1846 N  N   . LEU   A 1 319 ? -16.01184 -2.02574  -26.07884 1.000 11.50902 ? 319 LEU   A N   1 
ATOM   1847 C  CA  . LEU   A 1 319 ? -16.71056 -3.09227  -25.37238 1.000 9.01756  ? 319 LEU   A CA  1 
ATOM   1848 C  C   . LEU   A 1 319 ? -16.01355 -3.46423  -24.06653 1.000 12.57199 ? 319 LEU   A C   1 
ATOM   1849 O  O   . LEU   A 1 319 ? -16.02754 -4.62866  -23.65943 1.000 14.24469 ? 319 LEU   A O   1 
ATOM   1850 C  CB  . LEU   A 1 319 ? -16.84615 -4.32293  -26.26742 1.000 9.68236  ? 319 LEU   A CB  1 
ATOM   1851 C  CG  . LEU   A 1 319 ? -17.58661 -4.11073  -27.58728 1.000 19.53250 ? 319 LEU   A CG  1 
ATOM   1852 C  CD1 . LEU   A 1 319 ? -17.78414 -5.43267  -28.30661 1.000 15.22895 ? 319 LEU   A CD1 1 
ATOM   1853 C  CD2 . LEU   A 1 319 ? -18.91946 -3.42517  -27.34195 1.000 17.10490 ? 319 LEU   A CD2 1 
ATOM   1854 N  N   . SER   A 1 320 ? -15.41227 -2.48356  -23.39230 1.000 10.62467 ? 320 SER   A N   1 
ATOM   1855 C  CA  . SER   A 1 320 ? -14.59332 -2.74833  -22.21786 1.000 10.92984 ? 320 SER   A CA  1 
ATOM   1856 C  C   . SER   A 1 320 ? -15.32883 -2.56306  -20.89622 1.000 11.82681 ? 320 SER   A C   1 
ATOM   1857 O  O   . SER   A 1 320 ? -14.77027 -2.92409  -19.85414 1.000 9.19983  ? 320 SER   A O   1 
ATOM   1858 C  CB  . SER   A 1 320 ? -13.34818 -1.85163  -22.22445 1.000 12.93989 ? 320 SER   A CB  1 
ATOM   1859 O  OG  . SER   A 1 320 ? -13.68655 -0.50837  -21.93153 1.000 12.12684 ? 320 SER   A OG  1 
ATOM   1860 N  N   . ASN   A 1 321 ? -16.54812 -2.01001  -20.90566 1.000 13.60977 ? 321 ASN   A N   1 
ATOM   1861 C  CA  . ASN   A 1 321 ? -17.30454 -1.82933  -19.66444 1.000 10.08259 ? 321 ASN   A CA  1 
ATOM   1862 C  C   . ASN   A 1 321 ? -17.30101 -3.06389  -18.77139 1.000 12.36504 ? 321 ASN   A C   1 
ATOM   1863 O  O   . ASN   A 1 321 ? -16.96675 -2.93165  -17.58300 1.000 11.59559 ? 321 ASN   A O   1 
ATOM   1864 C  CB  . ASN   A 1 321 ? -18.75705 -1.41584  -19.95140 1.000 9.52881  ? 321 ASN   A CB  1 
ATOM   1865 C  CG  . ASN   A 1 321 ? -18.86699 -0.09709  -20.67699 1.000 14.55951 ? 321 ASN   A CG  1 
ATOM   1866 O  OD1 . ASN   A 1 321 ? -19.88440 0.18483   -21.30988 1.000 11.38482 ? 321 ASN   A OD1 1 
ATOM   1867 N  ND2 . ASN   A 1 321 ? -17.81841 0.71388   -20.60557 1.000 9.82442  ? 321 ASN   A ND2 1 
ATOM   1868 N  N   . PRO   A 1 322 ? -17.63892 -4.26884  -19.25125 1.000 12.40559 ? 322 PRO   A N   1 
ATOM   1869 C  CA  . PRO   A 1 322 ? -17.66594 -5.42902  -18.34618 1.000 14.08949 ? 322 PRO   A CA  1 
ATOM   1870 C  C   . PRO   A 1 322 ? -16.29691 -5.84652  -17.82954 1.000 11.24446 ? 322 PRO   A C   1 
ATOM   1871 O  O   . PRO   A 1 322 ? -16.23662 -6.65299  -16.89247 1.000 13.03780 ? 322 PRO   A O   1 
ATOM   1872 C  CB  . PRO   A 1 322 ? -18.29361 -6.53413  -19.20897 1.000 14.56259 ? 322 PRO   A CB  1 
ATOM   1873 C  CG  . PRO   A 1 322 ? -18.99914 -5.81542  -20.30978 1.000 9.37640  ? 322 PRO   A CG  1 
ATOM   1874 C  CD  . PRO   A 1 322 ? -18.13422 -4.63369  -20.59155 1.000 10.66504 ? 322 PRO   A CD  1 
ATOM   1875 N  N   . THR   A 1 323 ? -15.20641 -5.33384  -18.39877 1.000 11.66421 ? 323 THR   A N   1 
ATOM   1876 C  CA  . THR   A 1 323 ? -13.86319 -5.62024  -17.91022 1.000 12.65562 ? 323 THR   A CA  1 
ATOM   1877 C  C   . THR   A 1 323 ? -13.41618 -4.66097  -16.81545 1.000 10.37938 ? 323 THR   A C   1 
ATOM   1878 O  O   . THR   A 1 323 ? -12.34888 -4.86571  -16.22837 1.000 13.03202 ? 323 THR   A O   1 
ATOM   1879 C  CB  . THR   A 1 323 ? -12.84973 -5.56982  -19.05990 1.000 14.48319 ? 323 THR   A CB  1 
ATOM   1880 O  OG1 . THR   A 1 323 ? -12.54289 -4.20491  -19.37413 1.000 11.29708 ? 323 THR   A OG1 1 
ATOM   1881 C  CG2 . THR   A 1 323 ? -13.40347 -6.25787  -20.29785 1.000 14.53140 ? 323 THR   A CG2 1 
ATOM   1882 N  N   . LYS   A 1 324 ? -14.19377 -3.62986  -16.53256 1.000 12.11191 ? 324 LYS   A N   1 
ATOM   1883 C  CA  . LYS   A 1 324 ? -13.81100 -2.61657  -15.56561 1.000 12.98629 ? 324 LYS   A CA  1 
ATOM   1884 C  C   . LYS   A 1 324 ? -14.21830 -3.03719  -14.16215 1.000 12.26216 ? 324 LYS   A C   1 
ATOM   1885 O  O   . LYS   A 1 324 ? -15.05607 -3.92904  -13.99082 1.000 11.66482 ? 324 LYS   A O   1 
ATOM   1886 C  CB  . LYS   A 1 324 ? -14.45809 -1.28135  -15.92956 1.000 9.91697  ? 324 LYS   A CB  1 
ATOM   1887 C  CG  . LYS   A 1 324 ? -13.96619 -0.70907  -17.24807 1.000 11.06309 ? 324 LYS   A CG  1 
ATOM   1888 C  CD  . LYS   A 1 324 ? -12.48894 -0.35545  -17.17439 1.000 13.51335 ? 324 LYS   A CD  1 
ATOM   1889 C  CE  . LYS   A 1 324 ? -11.94934 0.04682   -18.53651 1.000 13.43823 ? 324 LYS   A CE  1 
ATOM   1890 N  NZ  . LYS   A 1 324 ? -12.55768 1.30710   -19.04033 1.000 12.24037 ? 324 LYS   A NZ  1 
ATOM   1891 N  N   . PRO   A 1 325 ? -13.61467 -2.43453  -13.13428 1.000 11.39539 ? 325 PRO   A N   1 
ATOM   1892 C  CA  . PRO   A 1 325 ? -14.05404 -2.70157  -11.76002 1.000 13.04528 ? 325 PRO   A CA  1 
ATOM   1893 C  C   . PRO   A 1 325 ? -15.56434 -2.56466  -11.63349 1.000 13.41946 ? 325 PRO   A C   1 
ATOM   1894 O  O   . PRO   A 1 325 ? -16.18097 -1.69508  -12.25265 1.000 14.59818 ? 325 PRO   A O   1 
ATOM   1895 C  CB  . PRO   A 1 325 ? -13.31028 -1.64185  -10.94290 1.000 13.42670 ? 325 PRO   A CB  1 
ATOM   1896 C  CG  . PRO   A 1 325 ? -12.04732 -1.41929  -11.71657 1.000 13.09086 ? 325 PRO   A CG  1 
ATOM   1897 C  CD  . PRO   A 1 325 ? -12.41562 -1.57566  -13.17243 1.000 14.16888 ? 325 PRO   A CD  1 
ATOM   1898 N  N   . LEU   A 1 326 ? -16.15509 -3.44589  -10.82119 1.000 11.70810 ? 326 LEU   A N   1 
ATOM   1899 C  CA  . LEU   A 1 326 ? -17.59862 -3.66405  -10.86315 1.000 14.18299 ? 326 LEU   A CA  1 
ATOM   1900 C  C   . LEU   A 1 326 ? -18.39087 -2.38057  -10.65110 1.000 14.70641 ? 326 LEU   A C   1 
ATOM   1901 O  O   . LEU   A 1 326 ? -19.45944 -2.20819  -11.24858 1.000 16.20779 ? 326 LEU   A O   1 
ATOM   1902 C  CB  . LEU   A 1 326 ? -17.99825 -4.70707  -9.82122  1.000 11.62553 ? 326 LEU   A CB  1 
ATOM   1903 C  CG  . LEU   A 1 326 ? -19.49514 -5.01406  -9.76037  1.000 16.58125 ? 326 LEU   A CG  1 
ATOM   1904 C  CD1 . LEU   A 1 326 ? -19.96929 -5.63517  -11.06759 1.000 12.85327 ? 326 LEU   A CD1 1 
ATOM   1905 C  CD2 . LEU   A 1 326 ? -19.81360 -5.91274  -8.58057  1.000 15.88261 ? 326 LEU   A CD2 1 
ATOM   1906 N  N   . GLN   A 1 327 ? -17.89160 -1.46629  -9.82050  1.000 13.84930 ? 327 GLN   A N   1 
ATOM   1907 C  CA  . GLN   A 1 327 ? -18.65018 -0.25159  -9.56100  1.000 16.13364 ? 327 GLN   A CA  1 
ATOM   1908 C  C   . GLN   A 1 327 ? -18.64806 0.69261   -10.75945 1.000 17.90009 ? 327 GLN   A C   1 
ATOM   1909 O  O   . GLN   A 1 327 ? -19.56681 1.50867   -10.89043 1.000 18.22997 ? 327 GLN   A O   1 
ATOM   1910 C  CB  . GLN   A 1 327 ? -18.11575 0.42865   -8.30214  1.000 15.43637 ? 327 GLN   A CB  1 
ATOM   1911 C  CG  . GLN   A 1 327 ? -16.95486 1.32565   -8.51190  1.000 15.39415 ? 327 GLN   A CG  1 
ATOM   1912 C  CD  . GLN   A 1 327 ? -15.63920 0.61987   -8.79696  1.000 20.78888 ? 327 GLN   A CD  1 
ATOM   1913 O  OE1 . GLN   A 1 327 ? -15.50549 -0.58234  -8.58718  1.000 19.14532 ? 327 GLN   A OE1 1 
ATOM   1914 N  NE2 . GLN   A 1 327 ? -14.65262 1.37959   -9.27261  1.000 25.07020 ? 327 GLN   A NE2 1 
ATOM   1915 N  N   . LEU   A 1 328 ? -17.65834 0.57910   -11.64892 1.000 13.52901 ? 328 LEU   A N   1 
ATOM   1916 C  CA  . LEU   A 1 328 ? -17.71901 1.27197   -12.93213 1.000 16.39073 ? 328 LEU   A CA  1 
ATOM   1917 C  C   . LEU   A 1 328 ? -18.63109 0.53752   -13.90904 1.000 14.72089 ? 328 LEU   A C   1 
ATOM   1918 O  O   . LEU   A 1 328 ? -19.51540 1.14707   -14.52119 1.000 11.07526 ? 328 LEU   A O   1 
ATOM   1919 C  CB  . LEU   A 1 328 ? -16.31281 1.41845   -13.51728 1.000 13.74419 ? 328 LEU   A CB  1 
ATOM   1920 C  CG  . LEU   A 1 328 ? -15.38392 2.35225   -12.74260 1.000 17.35165 ? 328 LEU   A CG  1 
ATOM   1921 C  CD1 . LEU   A 1 328 ? -13.99626 2.37199   -13.35832 1.000 12.74396 ? 328 LEU   A CD1 1 
ATOM   1922 C  CD2 . LEU   A 1 328 ? -15.97719 3.75087   -12.70115 1.000 17.12035 ? 328 LEU   A CD2 1 
ATOM   1923 N  N   . TYR   A 1 329 ? -18.41959 -0.77444  -14.06127 1.000 11.94355 ? 329 TYR   A N   1 
ATOM   1924 C  CA  . TYR   A 1 329 ? -19.25582 -1.60372  -14.92765 1.000 13.92712 ? 329 TYR   A CA  1 
ATOM   1925 C  C   . TYR   A 1 329 ? -20.73809 -1.37786  -14.64886 1.000 11.55727 ? 329 TYR   A C   1 
ATOM   1926 O  O   . TYR   A 1 329 ? -21.52782 -1.14298  -15.57060 1.000 11.93644 ? 329 TYR   A O   1 
ATOM   1927 C  CB  . TYR   A 1 329 ? -18.87418 -3.07730  -14.72699 1.000 10.96179 ? 329 TYR   A CB  1 
ATOM   1928 C  CG  . TYR   A 1 329 ? -19.63061 -4.11810  -15.54317 1.000 13.14789 ? 329 TYR   A CG  1 
ATOM   1929 C  CD1 . TYR   A 1 329 ? -20.44845 -3.76311  -16.61270 1.000 12.18115 ? 329 TYR   A CD1 1 
ATOM   1930 C  CD2 . TYR   A 1 329 ? -19.51724 -5.46837  -15.23242 1.000 13.68739 ? 329 TYR   A CD2 1 
ATOM   1931 C  CE1 . TYR   A 1 329 ? -21.13192 -4.72141  -17.34069 1.000 10.73786 ? 329 TYR   A CE1 1 
ATOM   1932 C  CE2 . TYR   A 1 329 ? -20.19194 -6.43236  -15.95688 1.000 14.99019 ? 329 TYR   A CE2 1 
ATOM   1933 C  CZ  . TYR   A 1 329 ? -20.99925 -6.05360  -17.00872 1.000 14.15712 ? 329 TYR   A CZ  1 
ATOM   1934 O  OH  . TYR   A 1 329 ? -21.67544 -7.00855  -17.73314 1.000 14.82224 ? 329 TYR   A OH  1 
ATOM   1935 N  N   . ARG   A 1 330 ? -21.12888 -1.42715  -13.37432 1.000 10.29116 ? 330 ARG   A N   1 
ATOM   1936 C  CA  . ARG   A 1 330 ? -22.54550 -1.35003  -13.03121 1.000 14.07619 ? 330 ARG   A CA  1 
ATOM   1937 C  C   . ARG   A 1 330 ? -23.16837 -0.03273  -13.47859 1.000 13.62631 ? 330 ARG   A C   1 
ATOM   1938 O  O   . ARG   A 1 330 ? -24.31919 -0.00732  -13.93097 1.000 16.74151 ? 330 ARG   A O   1 
ATOM   1939 C  CB  . ARG   A 1 330 ? -22.72815 -1.55241  -11.52962 1.000 14.83529 ? 330 ARG   A CB  1 
ATOM   1940 C  CG  . ARG   A 1 330 ? -22.81522 -3.01178  -11.12720 1.000 16.48307 ? 330 ARG   A CG  1 
ATOM   1941 C  CD  . ARG   A 1 330 ? -24.15871 -3.30714  -10.50146 1.000 21.30921 ? 330 ARG   A CD  1 
ATOM   1942 N  NE  . ARG   A 1 330 ? -24.07739 -3.33986  -9.04757  1.000 23.42987 ? 330 ARG   A NE  1 
ATOM   1943 C  CZ  . ARG   A 1 330 ? -25.12732 -3.23737  -8.24231  1.000 19.73549 ? 330 ARG   A CZ  1 
ATOM   1944 N  NH1 . ARG   A 1 330 ? -26.34136 -3.07950  -8.75333  1.000 18.37975 ? 330 ARG   A NH1 1 
ATOM   1945 N  NH2 . ARG   A 1 330 ? -24.96233 -3.28212  -6.92819  1.000 15.90256 ? 330 ARG   A NH2 1 
ATOM   1946 N  N   . GLN   A 1 331 ? -22.43087 1.07319   -13.36250 1.000 10.92849 ? 331 GLN   A N   1 
ATOM   1947 C  CA  . GLN   A 1 331 ? -22.97733 2.35155   -13.80701 1.000 14.35431 ? 331 GLN   A CA  1 
ATOM   1948 C  C   . GLN   A 1 331 ? -23.11229 2.39711   -15.32516 1.000 12.86789 ? 331 GLN   A C   1 
ATOM   1949 O  O   . GLN   A 1 331 ? -24.06050 2.99306   -15.85001 1.000 10.62872 ? 331 GLN   A O   1 
ATOM   1950 C  CB  . GLN   A 1 331 ? -22.11238 3.50508   -13.29330 1.000 15.26963 ? 331 GLN   A CB  1 
ATOM   1951 C  CG  . GLN   A 1 331 ? -22.34577 4.85173   -13.98258 1.000 23.39981 ? 331 GLN   A CG  1 
ATOM   1952 C  CD  . GLN   A 1 331 ? -23.67983 5.51135   -13.65414 1.000 28.56781 ? 331 GLN   A CD  1 
ATOM   1953 O  OE1 . GLN   A 1 331 ? -24.01138 6.56160   -14.20752 1.000 22.95127 ? 331 GLN   A OE1 1 
ATOM   1954 N  NE2 . GLN   A 1 331 ? -24.44254 4.90908   -12.74954 1.000 30.16608 ? 331 GLN   A NE2 1 
ATOM   1955 N  N   . TRP   A 1 332 ? -22.18378 1.76581   -16.04948 1.000 10.46245 ? 332 TRP   A N   1 
ATOM   1956 C  CA  . TRP   A 1 332 ? -22.35107 1.64428   -17.49453 1.000 10.49824 ? 332 TRP   A CA  1 
ATOM   1957 C  C   . TRP   A 1 332 ? -23.59383 0.83137   -17.83293 1.000 12.21075 ? 332 TRP   A C   1 
ATOM   1958 O  O   . TRP   A 1 332 ? -24.31586 1.15228   -18.78441 1.000 12.18022 ? 332 TRP   A O   1 
ATOM   1959 C  CB  . TRP   A 1 332 ? -21.11499 1.00828   -18.13116 1.000 8.74073  ? 332 TRP   A CB  1 
ATOM   1960 C  CG  . TRP   A 1 332 ? -19.88532 1.86228   -18.10313 1.000 9.58234  ? 332 TRP   A CG  1 
ATOM   1961 C  CD1 . TRP   A 1 332 ? -18.68732 1.55151   -17.53009 1.000 12.05556 ? 332 TRP   A CD1 1 
ATOM   1962 C  CD2 . TRP   A 1 332 ? -19.72939 3.16734   -18.67673 1.000 10.72704 ? 332 TRP   A CD2 1 
ATOM   1963 N  NE1 . TRP   A 1 332 ? -17.79401 2.57915   -17.71240 1.000 15.22851 ? 332 TRP   A NE1 1 
ATOM   1964 C  CE2 . TRP   A 1 332 ? -18.40931 3.58363   -18.41220 1.000 11.31116 ? 332 TRP   A CE2 1 
ATOM   1965 C  CE3 . TRP   A 1 332 ? -20.57722 4.02387   -19.38713 1.000 10.57804 ? 332 TRP   A CE3 1 
ATOM   1966 C  CZ2 . TRP   A 1 332 ? -17.91725 4.81832   -18.83159 1.000 12.28136 ? 332 TRP   A CZ2 1 
ATOM   1967 C  CZ3 . TRP   A 1 332 ? -20.08621 5.25013   -19.80250 1.000 9.87881  ? 332 TRP   A CZ3 1 
ATOM   1968 C  CH2 . TRP   A 1 332 ? -18.76896 5.63530   -19.52333 1.000 8.27583  ? 332 TRP   A CH2 1 
ATOM   1969 N  N   . THR   A 1 333 ? -23.86142 -0.22458  -17.06141 1.000 11.86034 ? 333 THR   A N   1 
ATOM   1970 C  CA  . THR   A 1 333 ? -25.04914 -1.03637  -17.30447 1.000 14.09688 ? 333 THR   A CA  1 
ATOM   1971 C  C   . THR   A 1 333 ? -26.32011 -0.23432  -17.05281 1.000 12.76674 ? 333 THR   A C   1 
ATOM   1972 O  O   . THR   A 1 333 ? -27.26582 -0.28825  -17.84807 1.000 11.27519 ? 333 THR   A O   1 
ATOM   1973 C  CB  . THR   A 1 333 ? -25.02160 -2.28979  -16.42979 1.000 17.91570 ? 333 THR   A CB  1 
ATOM   1974 O  OG1 . THR   A 1 333 ? -23.88653 -3.09398  -16.77484 1.000 11.99477 ? 333 THR   A OG1 1 
ATOM   1975 C  CG2 . THR   A 1 333 ? -26.28427 -3.10174  -16.63557 1.000 15.72244 ? 333 THR   A CG2 1 
ATOM   1976 N  N   . ASP   A 1 334 ? -26.36101 0.51558   -15.94601 1.000 14.41922 ? 334 ASP   A N   1 
ATOM   1977 C  CA  . ASP   A 1 334 ? -27.49178 1.40432   -15.69436 1.000 13.43595 ? 334 ASP   A CA  1 
ATOM   1978 C  C   . ASP   A 1 334 ? -27.74208 2.32412   -16.88062 1.000 14.48566 ? 334 ASP   A C   1 
ATOM   1979 O  O   . ASP   A 1 334 ? -28.89098 2.53306   -17.28689 1.000 16.34601 ? 334 ASP   A O   1 
ATOM   1980 C  CB  . ASP   A 1 334 ? -27.24724 2.23884   -14.43372 1.000 14.01187 ? 334 ASP   A CB  1 
ATOM   1981 C  CG  . ASP   A 1 334 ? -27.21157 1.40246   -13.17150 1.000 22.11134 ? 334 ASP   A CG  1 
ATOM   1982 O  OD1 . ASP   A 1 334 ? -27.46209 0.18273   -13.25735 1.000 19.20785 ? 334 ASP   A OD1 1 
ATOM   1983 O  OD2 . ASP   A 1 334 ? -26.94175 1.96836   -12.09030 1.000 18.20288 ? 334 ASP   A OD2 1 
ATOM   1984 N  N   . ARG   A 1 335 ? -26.67237 2.86739   -17.46254 1.000 12.39208 ? 335 ARG   A N   1 
ATOM   1985 C  CA  . ARG   A 1 335 ? -26.82930 3.87233   -18.50765 1.000 14.39988 ? 335 ARG   A CA  1 
ATOM   1986 C  C   . ARG   A 1 335 ? -27.27144 3.24772   -19.82711 1.000 15.57601 ? 335 ARG   A C   1 
ATOM   1987 O  O   . ARG   A 1 335 ? -28.15789 3.78018   -20.50521 1.000 13.58461 ? 335 ARG   A O   1 
ATOM   1988 C  CB  . ARG   A 1 335 ? -25.52760 4.65697   -18.67426 1.000 13.44704 ? 335 ARG   A CB  1 
ATOM   1989 C  CG  . ARG   A 1 335 ? -25.27734 5.65504   -17.54705 1.000 12.65930 ? 335 ARG   A CG  1 
ATOM   1990 C  CD  . ARG   A 1 335 ? -23.87521 6.25037   -17.61033 1.000 15.01260 ? 335 ARG   A CD  1 
ATOM   1991 N  NE  . ARG   A 1 335 ? -23.67411 7.28651   -16.59975 1.000 11.95310 ? 335 ARG   A NE  1 
ATOM   1992 C  CZ  . ARG   A 1 335 ? -23.94637 8.57418   -16.78583 1.000 18.41049 ? 335 ARG   A CZ  1 
ATOM   1993 N  NH1 . ARG   A 1 335 ? -24.42878 8.99026   -17.94983 1.000 10.78005 ? 335 ARG   A NH1 1 
ATOM   1994 N  NH2 . ARG   A 1 335 ? -23.73527 9.44639   -15.80887 1.000 11.25498 ? 335 ARG   A NH2 1 
ATOM   1995 N  N   . ILE   A 1 336 ? -26.67481 2.11527   -20.21083 1.000 13.69847 ? 336 ILE   A N   1 
ATOM   1996 C  CA  . ILE   A 1 336 ? -27.05284 1.49602   -21.48021 1.000 13.79740 ? 336 ILE   A CA  1 
ATOM   1997 C  C   . ILE   A 1 336 ? -28.49198 0.99467   -21.42312 1.000 13.19375 ? 336 ILE   A C   1 
ATOM   1998 O  O   . ILE   A 1 336 ? -29.22980 1.07553   -22.41309 1.000 13.33255 ? 336 ILE   A O   1 
ATOM   1999 C  CB  . ILE   A 1 336 ? -26.06765 0.37313   -21.86364 1.000 17.59539 ? 336 ILE   A CB  1 
ATOM   2000 C  CG1 . ILE   A 1 336 ? -26.27954 -0.03984  -23.32259 1.000 16.51394 ? 336 ILE   A CG1 1 
ATOM   2001 C  CG2 . ILE   A 1 336 ? -26.22858 -0.84334  -20.96093 1.000 18.45062 ? 336 ILE   A CG2 1 
ATOM   2002 C  CD1 . ILE   A 1 336 ? -25.96807 1.04738   -24.32288 1.000 16.80545 ? 336 ILE   A CD1 1 
ATOM   2003 N  N   . MET   A 1 337 ? -28.92054 0.48210   -20.26420 1.000 14.27259 ? 337 MET   A N   1 
ATOM   2004 C  CA  . MET   A 1 337 ? -30.30040 0.02557   -20.12893 1.000 16.55602 ? 337 MET   A CA  1 
ATOM   2005 C  C   . MET   A 1 337 ? -31.26316 1.19933   -20.18813 1.000 16.15492 ? 337 MET   A C   1 
ATOM   2006 O  O   . MET   A 1 337 ? -32.32367 1.11218   -20.81761 1.000 16.85963 ? 337 MET   A O   1 
ATOM   2007 C  CB  . MET   A 1 337 ? -30.48187 -0.74417  -18.82100 1.000 13.41213 ? 337 MET   A CB  1 
ATOM   2008 C  CG  . MET   A 1 337 ? -29.75100 -2.07279  -18.76953 1.000 14.95595 ? 337 MET   A CG  1 
ATOM   2009 S  SD  . MET   A 1 337 ? -30.01704 -3.08941  -20.23523 1.000 24.03944 ? 337 MET   A SD  1 
ATOM   2010 C  CE  . MET   A 1 337 ? -31.79736 -3.27193  -20.21284 1.000 26.20269 ? 337 MET   A CE  1 
ATOM   2011 N  N   . GLU   A 1 338 ? -30.90368 2.30482   -19.53465 1.000 16.10020 ? 338 GLU   A N   1 
ATOM   2012 C  CA  . GLU   A 1 338 ? -31.69323 3.52369   -19.64096 1.000 19.74284 ? 338 GLU   A CA  1 
ATOM   2013 C  C   . GLU   A 1 338 ? -31.85055 3.94507   -21.09872 1.000 26.03199 ? 338 GLU   A C   1 
ATOM   2014 O  O   . GLU   A 1 338 ? -32.96482 4.22941   -21.55142 1.000 20.33082 ? 338 GLU   A O   1 
ATOM   2015 C  CB  . GLU   A 1 338 ? -31.03828 4.62536   -18.79972 1.000 18.47667 ? 338 GLU   A CB  1 
ATOM   2016 C  CG  . GLU   A 1 338 ? -31.76911 5.95442   -18.75286 1.000 33.73852 ? 338 GLU   A CG  1 
ATOM   2017 C  CD  . GLU   A 1 338 ? -33.24144 5.79371   -18.45094 1.000 38.99933 ? 338 GLU   A CD  1 
ATOM   2018 O  OE1 . GLU   A 1 338 ? -34.06441 6.44734   -19.11873 1.000 46.86781 ? 338 GLU   A OE1 1 
ATOM   2019 O  OE2 . GLU   A 1 338 ? -33.58725 5.01672   -17.54156 1.000 53.38456 ? 338 GLU   A OE2 1 
ATOM   2020 N  N   . GLU   A 1 339 ? -30.75304 3.95634   -21.86046 1.000 19.10765 ? 339 GLU   A N   1 
ATOM   2021 C  CA  . GLU   A 1 339 ? -30.82570 4.34837   -23.26687 1.000 18.60872 ? 339 GLU   A CA  1 
ATOM   2022 C  C   . GLU   A 1 339 ? -31.65840 3.35863   -24.07412 1.000 17.04971 ? 339 GLU   A C   1 
ATOM   2023 O  O   . GLU   A 1 339 ? -32.47498 3.75623   -24.91343 1.000 18.51056 ? 339 GLU   A O   1 
ATOM   2024 C  CB  . GLU   A 1 339 ? -29.41596 4.46687   -23.84572 1.000 21.96490 ? 339 GLU   A CB  1 
ATOM   2025 C  CG  . GLU   A 1 339 ? -29.34344 5.00161   -25.26141 1.000 17.82360 ? 339 GLU   A CG  1 
ATOM   2026 C  CD  . GLU   A 1 339 ? -27.91552 5.27298   -25.67776 1.000 16.70152 ? 339 GLU   A CD  1 
ATOM   2027 O  OE1 . GLU   A 1 339 ? -27.14738 5.78869   -24.83923 1.000 15.22986 ? 339 GLU   A OE1 1 
ATOM   2028 O  OE2 . GLU   A 1 339 ? -27.55762 4.95944   -26.83165 1.000 15.13542 ? 339 GLU   A OE2 1 
ATOM   2029 N  N   . PHE   A 1 340 ? -31.45745 2.05930   -23.83623 1.000 13.85844 ? 340 PHE   A N   1 
ATOM   2030 C  CA  . PHE   A 1 340 ? -32.25885 1.04233   -24.51227 1.000 19.68864 ? 340 PHE   A CA  1 
ATOM   2031 C  C   . PHE   A 1 340 ? -33.74320 1.23606   -24.22925 1.000 25.39004 ? 340 PHE   A C   1 
ATOM   2032 O  O   . PHE   A 1 340 ? -34.57152 1.21609   -25.14748 1.000 22.39772 ? 340 PHE   A O   1 
ATOM   2033 C  CB  . PHE   A 1 340 ? -31.81883 -0.35586  -24.07573 1.000 19.04641 ? 340 PHE   A CB  1 
ATOM   2034 C  CG  . PHE   A 1 340 ? -30.54038 -0.82657  -24.71099 1.000 20.65633 ? 340 PHE   A CG  1 
ATOM   2035 C  CD1 . PHE   A 1 340 ? -29.89822 -0.06791  -25.67643 1.000 17.16922 ? 340 PHE   A CD1 1 
ATOM   2036 C  CD2 . PHE   A 1 340 ? -29.99013 -2.04441  -24.34783 1.000 22.88592 ? 340 PHE   A CD2 1 
ATOM   2037 C  CE1 . PHE   A 1 340 ? -28.72502 -0.51353  -26.25953 1.000 19.39779 ? 340 PHE   A CE1 1 
ATOM   2038 C  CE2 . PHE   A 1 340 ? -28.82153 -2.49421  -24.92590 1.000 20.60614 ? 340 PHE   A CE2 1 
ATOM   2039 C  CZ  . PHE   A 1 340 ? -28.18748 -1.72833  -25.88319 1.000 19.29732 ? 340 PHE   A CZ  1 
ATOM   2040 N  N   . PHE   A 1 341 ? -34.09613 1.42160   -22.95455 1.000 21.85670 ? 341 PHE   A N   1 
ATOM   2041 C  CA  . PHE   A 1 341 ? -35.49765 1.58869   -22.58720 1.000 25.48678 ? 341 PHE   A CA  1 
ATOM   2042 C  C   . PHE   A 1 341 ? -36.11224 2.80241   -23.26993 1.000 23.32049 ? 341 PHE   A C   1 
ATOM   2043 O  O   . PHE   A 1 341 ? -37.28203 2.76551   -23.67307 1.000 27.29302 ? 341 PHE   A O   1 
ATOM   2044 C  CB  . PHE   A 1 341 ? -35.63431 1.71238   -21.07045 1.000 17.85881 ? 341 PHE   A CB  1 
ATOM   2045 C  CG  . PHE   A 1 341 ? -35.33444 0.44775   -20.32709 1.000 22.73146 ? 341 PHE   A CG  1 
ATOM   2046 C  CD1 . PHE   A 1 341 ? -35.30342 -0.76981  -20.98619 1.000 24.01419 ? 341 PHE   A CD1 1 
ATOM   2047 C  CD2 . PHE   A 1 341 ? -35.09642 0.47452   -18.96422 1.000 24.14083 ? 341 PHE   A CD2 1 
ATOM   2048 C  CE1 . PHE   A 1 341 ? -35.03295 -1.93643  -20.30149 1.000 24.69141 ? 341 PHE   A CE1 1 
ATOM   2049 C  CE2 . PHE   A 1 341 ? -34.82579 -0.68826  -18.27297 1.000 26.31172 ? 341 PHE   A CE2 1 
ATOM   2050 C  CZ  . PHE   A 1 341 ? -34.79399 -1.89603  -18.94227 1.000 23.49114 ? 341 PHE   A CZ  1 
ATOM   2051 N  N   . ARG   A 1 342 ? -35.34351 3.89275   -23.40156 1.000 22.01667 ? 342 ARG   A N   1 
ATOM   2052 C  CA  . ARG   A 1 342 ? -35.88586 5.10077   -24.01878 1.000 23.77774 ? 342 ARG   A CA  1 
ATOM   2053 C  C   . ARG   A 1 342 ? -36.06193 4.92408   -25.52229 1.000 29.21202 ? 342 ARG   A C   1 
ATOM   2054 O  O   . ARG   A 1 342 ? -36.98691 5.49637   -26.10853 1.000 28.36342 ? 342 ARG   A O   1 
ATOM   2055 C  CB  . ARG   A 1 342 ? -35.01397 6.32282   -23.69549 1.000 26.88675 ? 342 ARG   A CB  1 
ATOM   2056 C  CG  . ARG   A 1 342 ? -35.00066 6.68796   -22.20532 1.000 32.23152 ? 342 ARG   A CG  1 
ATOM   2057 C  CD  . ARG   A 1 342 ? -34.87554 8.20562   -21.99729 1.000 49.32552 ? 342 ARG   A CD  1 
ATOM   2058 N  NE  . ARG   A 1 342 ? -34.06337 8.58999   -20.90121 1.000 53.48645 ? 342 ARG   A NE  1 
ATOM   2059 C  CZ  . ARG   A 1 342 ? -33.34270 9.72997   -20.88511 1.000 55.80326 ? 342 ARG   A CZ  1 
ATOM   2060 N  NH1 . ARG   A 1 342 ? -33.43723 10.50411  -21.97006 1.000 56.71361 ? 342 ARG   A NH1 1 
ATOM   2061 N  NH2 . ARG   A 1 342 ? -32.57209 10.07173  -19.88040 1.000 53.38874 ? 342 ARG   A NH2 1 
ATOM   2062 N  N   . GLN   A 1 343 ? -35.20664 4.11914   -26.16189 1.000 22.37213 ? 343 GLN   A N   1 
ATOM   2063 C  CA  . GLN   A 1 343 ? -35.47991 3.72221   -27.54085 1.000 27.94468 ? 343 GLN   A CA  1 
ATOM   2064 C  C   . GLN   A 1 343 ? -36.70441 2.81759   -27.61222 1.000 29.43096 ? 343 GLN   A C   1 
ATOM   2065 O  O   . GLN   A 1 343 ? -37.55213 2.97476   -28.50021 1.000 24.93187 ? 343 GLN   A O   1 
ATOM   2066 C  CB  . GLN   A 1 343 ? -34.26584 3.01976   -28.15339 1.000 19.95751 ? 343 GLN   A CB  1 
ATOM   2067 C  CG  . GLN   A 1 343 ? -34.57258 2.39168   -29.50767 1.000 23.87426 ? 343 GLN   A CG  1 
ATOM   2068 C  CD  . GLN   A 1 343 ? -33.41315 1.61042   -30.09730 1.000 22.46975 ? 343 GLN   A CD  1 
ATOM   2069 O  OE1 . GLN   A 1 343 ? -32.25249 1.99988   -29.96970 1.000 15.93886 ? 343 GLN   A OE1 1 
ATOM   2070 N  NE2 . GLN   A 1 343 ? -33.72757 0.50011   -30.75676 1.000 19.20137 ? 343 GLN   A NE2 1 
ATOM   2071 N  N   . GLY   A 1 344 ? -36.81454 1.86876   -26.67844 1.000 25.41041 ? 344 GLY   A N   1 
ATOM   2072 C  CA  . GLY   A 1 344 ? -37.96695 0.98497   -26.65643 1.000 33.51699 ? 344 GLY   A CA  1 
ATOM   2073 C  C   . GLY   A 1 344 ? -39.27969 1.71802   -26.47092 1.000 33.50837 ? 344 GLY   A C   1 
ATOM   2074 O  O   . GLY   A 1 344 ? -40.30458 1.30920   -27.02338 1.000 37.89343 ? 344 GLY   A O   1 
ATOM   2075 N  N   . ASP   A 1 345 ? -39.27264 2.80037   -25.68786 1.000 28.17975 ? 345 ASP   A N   1 
ATOM   2076 C  CA  . ASP   A 1 345 ? -40.45972 3.64233   -25.57219 1.000 34.98195 ? 345 ASP   A CA  1 
ATOM   2077 C  C   . ASP   A 1 345 ? -40.84936 4.21943   -26.92651 1.000 40.62239 ? 345 ASP   A C   1 
ATOM   2078 O  O   . ASP   A 1 345 ? -42.00676 4.11340   -27.34972 1.000 42.91250 ? 345 ASP   A O   1 
ATOM   2079 C  CB  . ASP   A 1 345 ? -40.21479 4.76282   -24.56005 1.000 29.40348 ? 345 ASP   A CB  1 
ATOM   2080 C  CG  . ASP   A 1 345 ? -40.11237 4.24986   -23.13927 1.000 28.69797 ? 345 ASP   A CG  1 
ATOM   2081 O  OD1 . ASP   A 1 345 ? -40.17282 3.01737   -22.95322 1.000 28.33355 ? 345 ASP   A OD1 1 
ATOM   2082 O  OD2 . ASP   A 1 345 ? -39.97336 5.07410   -22.21046 1.000 25.14101 ? 345 ASP   A OD2 1 
ATOM   2083 N  N   . ARG   A 1 346 ? -39.88683 4.83647   -27.62135 1.000 34.79598 ? 346 ARG   A N   1 
ATOM   2084 C  CA  . ARG   A 1 346 ? -40.14178 5.35527   -28.96234 1.000 35.33736 ? 346 ARG   A CA  1 
ATOM   2085 C  C   . ARG   A 1 346 ? -40.69973 4.27386   -29.87720 1.000 39.01028 ? 346 ARG   A C   1 
ATOM   2086 O  O   . ARG   A 1 346 ? -41.61028 4.52952   -30.67343 1.000 51.32785 ? 346 ARG   A O   1 
ATOM   2087 C  CB  . ARG   A 1 346 ? -38.85787 5.93111   -29.56387 1.000 33.90150 ? 346 ARG   A CB  1 
ATOM   2088 C  CG  . ARG   A 1 346 ? -38.24467 7.09803   -28.81165 1.000 30.84400 ? 346 ARG   A CG  1 
ATOM   2089 C  CD  . ARG   A 1 346 ? -37.38794 7.93269   -29.75668 1.000 36.21199 ? 346 ARG   A CD  1 
ATOM   2090 N  NE  . ARG   A 1 346 ? -36.01611 8.09825   -29.28330 1.000 42.61416 ? 346 ARG   A NE  1 
ATOM   2091 C  CZ  . ARG   A 1 346 ? -35.10161 8.84183   -29.89870 1.000 36.59822 ? 346 ARG   A CZ  1 
ATOM   2092 N  NH1 . ARG   A 1 346 ? -35.41366 9.48899   -31.01328 1.000 37.58045 ? 346 ARG   A NH1 1 
ATOM   2093 N  NH2 . ARG   A 1 346 ? -33.87574 8.94089   -29.40094 1.000 41.52768 ? 346 ARG   A NH2 1 
ATOM   2094 N  N   . GLU   A 1 347 ? -40.16368 3.05593   -29.77503 1.000 35.54661 ? 347 GLU   A N   1 
ATOM   2095 C  CA  . GLU   A 1 347 ? -40.63497 1.95921   -30.61422 1.000 39.69947 ? 347 GLU   A CA  1 
ATOM   2096 C  C   . GLU   A 1 347 ? -42.04882 1.54056   -30.23325 1.000 49.40765 ? 347 GLU   A C   1 
ATOM   2097 O  O   . GLU   A 1 347 ? -42.93044 1.43904   -31.09475 1.000 48.85094 ? 347 GLU   A O   1 
ATOM   2098 C  CB  . GLU   A 1 347 ? -39.68367 0.76877   -30.50423 1.000 37.46323 ? 347 GLU   A CB  1 
ATOM   2099 C  CG  . GLU   A 1 347 ? -38.31535 0.98483   -31.12056 1.000 33.67293 ? 347 GLU   A CG  1 
ATOM   2100 C  CD  . GLU   A 1 347 ? -37.37164 -0.16184  -30.82055 1.000 32.73711 ? 347 GLU   A CD  1 
ATOM   2101 O  OE1 . GLU   A 1 347 ? -37.61237 -0.87831  -29.82616 1.000 34.41896 ? 347 GLU   A OE1 1 
ATOM   2102 O  OE2 . GLU   A 1 347 ? -36.39755 -0.35365  -31.57856 1.000 28.16522 ? 347 GLU   A OE2 1 
ATOM   2103 N  N   . ARG   A 1 348 ? -42.28027 1.28449   -28.94246 1.000 46.74744 ? 348 ARG   A N   1 
ATOM   2104 C  CA  . ARG   A 1 348 ? -43.58795 0.81075   -28.50146 1.000 50.61150 ? 348 ARG   A CA  1 
ATOM   2105 C  C   . ARG   A 1 348 ? -44.68832 1.81187   -28.83121 1.000 44.56112 ? 348 ARG   A C   1 
ATOM   2106 O  O   . ARG   A 1 348 ? -45.83834 1.41679   -29.05601 1.000 52.62589 ? 348 ARG   A O   1 
ATOM   2107 C  CB  . ARG   A 1 348 ? -43.55311 0.51611   -27.00153 1.000 48.59529 ? 348 ARG   A CB  1 
ATOM   2108 C  CG  . ARG   A 1 348 ? -44.73463 -0.28820  -26.49370 1.000 47.84026 ? 348 ARG   A CG  1 
ATOM   2109 C  CD  . ARG   A 1 348 ? -44.56051 -0.66064  -25.02868 1.000 38.41013 ? 348 ARG   A CD  1 
ATOM   2110 N  NE  . ARG   A 1 348 ? -43.80047 0.34256   -24.28649 1.000 44.80377 ? 348 ARG   A NE  1 
ATOM   2111 C  CZ  . ARG   A 1 348 ? -42.64923 0.10205   -23.66578 1.000 37.74082 ? 348 ARG   A CZ  1 
ATOM   2112 N  NH1 . ARG   A 1 348 ? -42.12363 -1.11507  -23.68428 1.000 34.18620 ? 348 ARG   A NH1 1 
ATOM   2113 N  NH2 . ARG   A 1 348 ? -42.02783 1.07649   -23.01590 1.000 38.76933 ? 348 ARG   A NH2 1 
ATOM   2114 N  N   . GLU   A 1 349 ? -44.35504 3.10504   -28.87166 1.000 46.24164 ? 349 GLU   A N   1 
ATOM   2115 C  CA  . GLU   A 1 349 ? -45.31028 4.11081   -29.32788 1.000 46.47878 ? 349 GLU   A CA  1 
ATOM   2116 C  C   . GLU   A 1 349 ? -45.76154 3.83092   -30.75462 1.000 52.13322 ? 349 GLU   A C   1 
ATOM   2117 O  O   . GLU   A 1 349 ? -46.96093 3.71714   -31.03247 1.000 53.30291 ? 349 GLU   A O   1 
ATOM   2118 C  CB  . GLU   A 1 349 ? -44.68900 5.50497   -29.25394 1.000 45.05003 ? 349 GLU   A CB  1 
ATOM   2119 C  CG  . GLU   A 1 349 ? -44.55516 6.10648   -27.87518 1.000 45.15765 ? 349 GLU   A CG  1 
ATOM   2120 C  CD  . GLU   A 1 349 ? -44.12409 7.55874   -27.94591 1.000 56.84029 ? 349 GLU   A CD  1 
ATOM   2121 O  OE1 . GLU   A 1 349 ? -45.00816 8.43998   -27.99558 1.000 60.85199 ? 349 GLU   A OE1 1 
ATOM   2122 O  OE2 . GLU   A 1 349 ? -42.90224 7.81819   -27.97500 1.000 59.13807 ? 349 GLU   A OE2 1 
ATOM   2123 N  N   . ARG   A 1 350 ? -44.80979 3.72830   -31.67426 1.000 47.56488 ? 350 ARG   A N   1 
ATOM   2124 C  CA  . ARG   A 1 350 ? -45.06731 3.58324   -33.10173 1.000 42.25211 ? 350 ARG   A CA  1 
ATOM   2125 C  C   . ARG   A 1 350 ? -45.62916 2.22865   -33.47841 1.000 43.31794 ? 350 ARG   A C   1 
ATOM   2126 O  O   . ARG   A 1 350 ? -45.67949 1.95118   -34.68347 1.000 40.26430 ? 350 ARG   A O   1 
ATOM   2127 C  CB  . ARG   A 1 350 ? -43.77632 3.82963   -33.88471 1.000 42.31732 ? 350 ARG   A CB  1 
ATOM   2128 C  CG  . ARG   A 1 350 ? -43.11755 5.18024   -33.63857 1.000 38.92452 ? 350 ARG   A CG  1 
ATOM   2129 C  CD  . ARG   A 1 350 ? -41.66477 5.13010   -34.08853 1.000 39.57608 ? 350 ARG   A CD  1 
ATOM   2130 N  NE  . ARG   A 1 350 ? -41.01878 6.43699   -34.15808 1.000 39.81900 ? 350 ARG   A NE  1 
ATOM   2131 C  CZ  . ARG   A 1 350 ? -40.75934 7.07700   -35.29364 1.000 35.71488 ? 350 ARG   A CZ  1 
ATOM   2132 N  NH1 . ARG   A 1 350 ? -41.09948 6.53219   -36.45407 1.000 31.00821 ? 350 ARG   A NH1 1 
ATOM   2133 N  NH2 . ARG   A 1 350 ? -40.16100 8.26037   -35.27096 1.000 37.07983 ? 350 ARG   A NH2 1 
ATOM   2134 N  N   . GLY   A 1 351 ? -46.04658 1.37519   -32.54570 1.000 40.55702 ? 351 GLY   A N   1 
ATOM   2135 C  CA  . GLY   A 1 351 ? -46.45521 0.03433   -32.90891 1.000 35.83290 ? 351 GLY   A CA  1 
ATOM   2136 C  C   . GLY   A 1 351 ? -45.34121 -0.84690  -33.42114 1.000 47.27892 ? 351 GLY   A C   1 
ATOM   2137 O  O   . GLY   A 1 351 ? -45.61400 -1.95027  -33.90363 1.000 43.08324 ? 351 GLY   A O   1 
ATOM   2138 N  N   . MET   A 1 352 ? -44.09432 -0.39163  -33.33945 1.000 41.28521 ? 352 MET   A N   1 
ATOM   2139 C  CA  . MET   A 1 352 ? -42.96753 -1.20361  -33.76643 1.000 45.06223 ? 352 MET   A CA  1 
ATOM   2140 C  C   . MET   A 1 352 ? -42.69694 -2.31266  -32.75995 1.000 41.32448 ? 352 MET   A C   1 
ATOM   2141 O  O   . MET   A 1 352 ? -42.93179 -2.16483  -31.55735 1.000 44.42780 ? 352 MET   A O   1 
ATOM   2142 C  CB  . MET   A 1 352 ? -41.71388 -0.34326  -33.92253 1.000 42.21624 ? 352 MET   A CB  1 
ATOM   2143 C  CG  . MET   A 1 352 ? -41.87088 0.82533   -34.87265 1.000 43.01706 ? 352 MET   A CG  1 
ATOM   2144 S  SD  . MET   A 1 352 ? -40.48491 1.97528   -34.78495 1.000 38.49016 ? 352 MET   A SD  1 
ATOM   2145 C  CE  . MET   A 1 352 ? -39.11148 0.91079   -35.21148 1.000 30.56177 ? 352 MET   A CE  1 
ATOM   2146 N  N   . GLU   A 1 353 ? -42.20197 -3.43634  -33.26679 1.000 39.48767 ? 353 GLU   A N   1 
ATOM   2147 C  CA  . GLU   A 1 353 ? -41.68418 -4.47582  -32.39183 1.000 39.08302 ? 353 GLU   A CA  1 
ATOM   2148 C  C   . GLU   A 1 353 ? -40.51627 -3.91707  -31.59326 1.000 45.95164 ? 353 GLU   A C   1 
ATOM   2149 O  O   . GLU   A 1 353 ? -39.54913 -3.40640  -32.16745 1.000 39.75284 ? 353 GLU   A O   1 
ATOM   2150 C  CB  . GLU   A 1 353 ? -41.24988 -5.68783  -33.21386 1.000 37.42939 ? 353 GLU   A CB  1 
ATOM   2151 C  CG  . GLU   A 1 353 ? -40.76125 -6.86825  -32.39049 1.000 44.09831 ? 353 GLU   A CG  1 
ATOM   2152 C  CD  . GLU   A 1 353 ? -40.46057 -8.08317  -33.24684 1.000 55.85812 ? 353 GLU   A CD  1 
ATOM   2153 O  OE1 . GLU   A 1 353 ? -40.54919 -7.97087  -34.48802 1.000 57.82084 ? 353 GLU   A OE1 1 
ATOM   2154 O  OE2 . GLU   A 1 353 ? -40.13615 -9.14884  -32.68123 1.000 55.54727 ? 353 GLU   A OE2 1 
ATOM   2155 N  N   . ILE   A 1 354 ? -40.62045 -3.98530  -30.26714 1.000 40.76927 ? 354 ILE   A N   1 
ATOM   2156 C  CA  . ILE   A 1 354 ? -39.57104 -3.45188  -29.40994 1.000 34.43607 ? 354 ILE   A CA  1 
ATOM   2157 C  C   . ILE   A 1 354 ? -38.30472 -4.27493  -29.59575 1.000 38.72131 ? 354 ILE   A C   1 
ATOM   2158 O  O   . ILE   A 1 354 ? -38.33970 -5.51253  -29.57728 1.000 37.06740 ? 354 ILE   A O   1 
ATOM   2159 C  CB  . ILE   A 1 354 ? -40.02779 -3.43899  -27.94438 1.000 40.71493 ? 354 ILE   A CB  1 
ATOM   2160 C  CG1 . ILE   A 1 354 ? -41.29294 -2.59185  -27.79459 1.000 32.53881 ? 354 ILE   A CG1 1 
ATOM   2161 C  CG2 . ILE   A 1 354 ? -38.92205 -2.90625  -27.04741 1.000 35.33327 ? 354 ILE   A CG2 1 
ATOM   2162 C  CD1 . ILE   A 1 354 ? -42.07452 -2.88184  -26.53458 1.000 38.21933 ? 354 ILE   A CD1 1 
ATOM   2163 N  N   . SER   A 1 355 ? -37.17939 -3.58627  -29.79603 1.000 35.29467 ? 355 SER   A N   1 
ATOM   2164 C  CA  . SER   A 1 355 ? -35.90782 -4.25750  -29.99645 1.000 31.34098 ? 355 SER   A CA  1 
ATOM   2165 C  C   . SER   A 1 355 ? -35.54437 -5.08297  -28.76435 1.000 33.19944 ? 355 SER   A C   1 
ATOM   2166 O  O   . SER   A 1 355 ? -36.01106 -4.80171  -27.65697 1.000 33.57966 ? 355 SER   A O   1 
ATOM   2167 C  CB  . SER   A 1 355 ? -34.81204 -3.23393  -30.29031 1.000 32.05282 ? 355 SER   A CB  1 
ATOM   2168 O  OG  . SER   A 1 355 ? -35.14617 -2.44306  -31.41680 1.000 28.49309 ? 355 SER   A OG  1 
ATOM   2169 N  N   . PRO   A 1 356 ? -34.72574 -6.12026  -28.93755 1.000 37.41195 ? 356 PRO   A N   1 
ATOM   2170 C  CA  . PRO   A 1 356 ? -34.27921 -6.90141  -27.77772 1.000 32.12036 ? 356 PRO   A CA  1 
ATOM   2171 C  C   . PRO   A 1 356 ? -33.57034 -6.01592  -26.76292 1.000 37.82715 ? 356 PRO   A C   1 
ATOM   2172 O  O   . PRO   A 1 356 ? -32.71668 -5.19818  -27.11611 1.000 28.71636 ? 356 PRO   A O   1 
ATOM   2173 C  CB  . PRO   A 1 356 ? -33.33256 -7.94209  -28.39159 1.000 34.59744 ? 356 PRO   A CB  1 
ATOM   2174 C  CG  . PRO   A 1 356 ? -32.96602 -7.39321  -29.74138 1.000 39.47488 ? 356 PRO   A CG  1 
ATOM   2175 C  CD  . PRO   A 1 356 ? -34.18332 -6.65445  -30.19788 1.000 36.74472 ? 356 PRO   A CD  1 
ATOM   2176 N  N   . MET   A 1 357 ? -33.96256 -6.16837  -25.49746 1.000 35.78539 ? 357 MET   A N   1 
ATOM   2177 C  CA  . MET   A 1 357 ? -33.44816 -5.48437  -24.30945 1.000 31.56518 ? 357 MET   A CA  1 
ATOM   2178 C  C   . MET   A 1 357 ? -33.98479 -4.06213  -24.16008 1.000 26.85562 ? 357 MET   A C   1 
ATOM   2179 O  O   . MET   A 1 357 ? -33.59137 -3.37742  -23.20795 1.000 33.08761 ? 357 MET   A O   1 
ATOM   2180 C  CB  . MET   A 1 357 ? -31.91129 -5.43586  -24.26724 1.000 23.91482 ? 357 MET   A CB  1 
ATOM   2181 C  CG  . MET   A 1 357 ? -31.25099 -6.80342  -24.23881 1.000 22.96033 ? 357 MET   A CG  1 
ATOM   2182 S  SD  . MET   A 1 357 ? -29.50306 -6.74185  -24.67435 1.000 34.03040 ? 357 MET   A SD  1 
ATOM   2183 C  CE  . MET   A 1 357 ? -29.60148 -6.35323  -26.42040 1.000 29.25038 ? 357 MET   A CE  1 
ATOM   2184 N  N   . CYS   A 1 358 ? -34.86894 -3.59597  -25.04100 1.000 23.76867 ? 358 CYS   A N   1 
ATOM   2185 C  CA  . CYS   A 1 358 ? -35.38449 -2.23379  -24.97825 1.000 24.75354 ? 358 CYS   A CA  1 
ATOM   2186 C  C   . CYS   A 1 358 ? -36.74833 -2.13671  -24.30531 1.000 28.23246 ? 358 CYS   A C   1 
ATOM   2187 O  O   . CYS   A 1 358 ? -37.28778 -1.03152  -24.18783 1.000 27.11651 ? 358 CYS   A O   1 
ATOM   2188 C  CB  . CYS   A 1 358 ? -35.46104 -1.63446  -26.38742 1.000 27.37518 ? 358 CYS   A CB  1 
ATOM   2189 S  SG  . CYS   A 1 358 ? -33.85720 -1.44687  -27.20557 1.000 25.53931 ? 358 CYS   A SG  1 
ATOM   2190 N  N   . ASP   A 1 359 ? -37.31311 -3.25589  -23.85641 1.000 31.46152 ? 359 ASP   A N   1 
ATOM   2191 C  CA  . ASP   A 1 359 ? -38.63734 -3.28433  -23.23739 1.000 34.96097 ? 359 ASP   A CA  1 
ATOM   2192 C  C   . ASP   A 1 359 ? -38.45950 -3.23094  -21.72287 1.000 35.88699 ? 359 ASP   A C   1 
ATOM   2193 O  O   . ASP   A 1 359 ? -38.11648 -4.23357  -21.09311 1.000 32.30860 ? 359 ASP   A O   1 
ATOM   2194 C  CB  . ASP   A 1 359 ? -39.40502 -4.53136  -23.66648 1.000 33.19763 ? 359 ASP   A CB  1 
ATOM   2195 C  CG  . ASP   A 1 359 ? -40.87697 -4.46723  -23.30247 1.000 41.86776 ? 359 ASP   A CG  1 
ATOM   2196 O  OD1 . ASP   A 1 359 ? -41.26570 -3.55445  -22.54315 1.000 30.89342 ? 359 ASP   A OD1 1 
ATOM   2197 O  OD2 . ASP   A 1 359 ? -41.64631 -5.33002  -23.77788 1.000 40.34388 ? 359 ASP   A OD2 1 
ATOM   2198 N  N   . LYS   A 1 360 ? -38.70803 -2.05600  -21.13624 1.000 33.64076 ? 360 LYS   A N   1 
ATOM   2199 C  CA  . LYS   A 1 360 ? -38.59245 -1.91430  -19.68752 1.000 31.51123 ? 360 LYS   A CA  1 
ATOM   2200 C  C   . LYS   A 1 360 ? -39.59356 -2.79778  -18.95422 1.000 42.02307 ? 360 LYS   A C   1 
ATOM   2201 O  O   . LYS   A 1 360 ? -39.32898 -3.23248  -17.82727 1.000 43.41424 ? 360 LYS   A O   1 
ATOM   2202 C  CB  . LYS   A 1 360 ? -38.77812 -0.44990  -19.28751 1.000 30.44119 ? 360 LYS   A CB  1 
ATOM   2203 C  CG  . LYS   A 1 360 ? -40.12349 0.13447   -19.68386 1.000 36.82619 ? 360 LYS   A CG  1 
ATOM   2204 C  CD  . LYS   A 1 360 ? -40.16762 1.63666   -19.45796 1.000 32.25764 ? 360 LYS   A CD  1 
ATOM   2205 C  CE  . LYS   A 1 360 ? -41.48122 2.22518   -19.95044 1.000 26.62666 ? 360 LYS   A CE  1 
ATOM   2206 N  NZ  . LYS   A 1 360 ? -41.48565 3.71464   -19.93207 1.000 30.96766 ? 360 LYS   A NZ  1 
ATOM   2207 N  N   . HIS   A 1 361 ? -40.74065 -3.07798  -19.57342 1.000 38.50472 ? 361 HIS   A N   1 
ATOM   2208 C  CA  . HIS   A 1 361 ? -41.73762 -3.95455  -18.97469 1.000 40.69628 ? 361 HIS   A CA  1 
ATOM   2209 C  C   . HIS   A 1 361 ? -41.40848 -5.42953  -19.15264 1.000 44.23946 ? 361 HIS   A C   1 
ATOM   2210 O  O   . HIS   A 1 361 ? -42.11366 -6.27646  -18.59302 1.000 48.28629 ? 361 HIS   A O   1 
ATOM   2211 C  CB  . HIS   A 1 361 ? -43.11791 -3.66390  -19.56875 1.000 36.16333 ? 361 HIS   A CB  1 
ATOM   2212 C  CG  . HIS   A 1 361 ? -43.53248 -2.22957  -19.46174 1.000 30.34935 ? 361 HIS   A CG  1 
ATOM   2213 N  ND1 . HIS   A 1 361 ? -43.52916 -1.54070  -18.26796 1.000 31.04519 ? 361 HIS   A ND1 1 
ATOM   2214 C  CD2 . HIS   A 1 361 ? -43.97011 -1.35573  -20.39888 1.000 31.73099 ? 361 HIS   A CD2 1 
ATOM   2215 C  CE1 . HIS   A 1 361 ? -43.94316 -0.30335  -18.47474 1.000 29.94937 ? 361 HIS   A CE1 1 
ATOM   2216 N  NE2 . HIS   A 1 361 ? -44.21794 -0.16540  -19.75931 1.000 35.37758 ? 361 HIS   A NE2 1 
ATOM   2217 N  N   . ASN   A 1 362 ? -40.36475 -5.75121  -19.91610 1.000 41.66362 ? 362 ASN   A N   1 
ATOM   2218 C  CA  . ASN   A 1 362 ? -39.96031 -7.13118  -20.14952 1.000 40.91275 ? 362 ASN   A CA  1 
ATOM   2219 C  C   . ASN   A 1 362 ? -38.49451 -7.16926  -20.56721 1.000 44.20649 ? 362 ASN   A C   1 
ATOM   2220 O  O   . ASN   A 1 362 ? -38.17024 -7.35745  -21.74499 1.000 48.40411 ? 362 ASN   A O   1 
ATOM   2221 C  CB  . ASN   A 1 362 ? -40.85877 -7.78531  -21.20464 1.000 44.89276 ? 362 ASN   A CB  1 
ATOM   2222 C  CG  . ASN   A 1 362 ? -40.33430 -9.13306  -21.67171 1.000 56.02430 ? 362 ASN   A CG  1 
ATOM   2223 O  OD1 . ASN   A 1 362 ? -39.77753 -9.90287  -20.88869 1.000 59.49885 ? 362 ASN   A OD1 1 
ATOM   2224 N  ND2 . ASN   A 1 362 ? -40.49997 -9.41707  -22.95809 1.000 56.87076 ? 362 ASN   A ND2 1 
ATOM   2225 N  N   . ALA   A 1 363 ? -37.60311 -6.95414  -19.60490 1.000 37.87523 ? 363 ALA   A N   1 
ATOM   2226 C  CA  . ALA   A 1 363 ? -36.17159 -7.07038  -19.82378 1.000 40.69266 ? 363 ALA   A CA  1 
ATOM   2227 C  C   . ALA   A 1 363 ? -35.53373 -7.64704  -18.57315 1.000 29.96233 ? 363 ALA   A C   1 
ATOM   2228 O  O   . ALA   A 1 363 ? -35.96900 -7.37196  -17.45214 1.000 38.91035 ? 363 ALA   A O   1 
ATOM   2229 C  CB  . ALA   A 1 363 ? -35.51938 -5.72188  -20.15894 1.000 37.09638 ? 363 ALA   A CB  1 
ATOM   2230 N  N   . SER   A 1 364 ? -34.50540 -8.45663  -18.77532 1.000 28.59978 ? 364 SER   A N   1 
ATOM   2231 C  CA  . SER   A 1 364 ? -33.68154 -8.96151  -17.68467 1.000 27.41933 ? 364 SER   A CA  1 
ATOM   2232 C  C   . SER   A 1 364 ? -32.30102 -8.33914  -17.84948 1.000 23.99393 ? 364 SER   A C   1 
ATOM   2233 O  O   . SER   A 1 364 ? -31.50798 -8.77667  -18.68866 1.000 22.81078 ? 364 SER   A O   1 
ATOM   2234 C  CB  . SER   A 1 364 ? -33.61987 -10.48407 -17.68643 1.000 31.11509 ? 364 SER   A CB  1 
ATOM   2235 O  OG  . SER   A 1 364 ? -32.73870 -10.93991 -16.67422 1.000 34.16219 ? 364 SER   A OG  1 
ATOM   2236 N  N   . VAL   A 1 365 ? -32.03387 -7.30031  -17.05536 1.000 19.10420 ? 365 VAL   A N   1 
ATOM   2237 C  CA  . VAL   A 1 365 ? -30.73732 -6.62818  -17.09583 1.000 23.19496 ? 365 VAL   A CA  1 
ATOM   2238 C  C   . VAL   A 1 365 ? -29.61476 -7.63060  -16.86250 1.000 22.77059 ? 365 VAL   A C   1 
ATOM   2239 O  O   . VAL   A 1 365 ? -28.65359 -7.71142  -17.63711 1.000 21.86996 ? 365 VAL   A O   1 
ATOM   2240 C  CB  . VAL   A 1 365 ? -30.69801 -5.48989  -16.06050 1.000 18.70357 ? 365 VAL   A CB  1 
ATOM   2241 C  CG1 . VAL   A 1 365 ? -29.34061 -4.82233  -16.05760 1.000 21.50224 ? 365 VAL   A CG1 1 
ATOM   2242 C  CG2 . VAL   A 1 365 ? -31.79881 -4.47792  -16.33998 1.000 22.29638 ? 365 VAL   A CG2 1 
ATOM   2243 N  N   . GLU   A 1 366 ? -29.73775 -8.42735  -15.79907 1.000 16.92753 ? 366 GLU   A N   1 
ATOM   2244 C  CA  . GLU   A 1 366 ? -28.66442 -9.33962  -15.41712 1.000 21.91409 ? 366 GLU   A CA  1 
ATOM   2245 C  C   . GLU   A 1 366 ? -28.45448 -10.42122 -16.47035 1.000 20.58407 ? 366 GLU   A C   1 
ATOM   2246 O  O   . GLU   A 1 366 ? -27.31709 -10.72228 -16.84797 1.000 20.75152 ? 366 GLU   A O   1 
ATOM   2247 C  CB  . GLU   A 1 366 ? -28.96976 -9.96058  -14.05352 1.000 22.39581 ? 366 GLU   A CB  1 
ATOM   2248 C  CG  . GLU   A 1 366 ? -29.06565 -8.95110  -12.91381 1.000 20.30434 ? 366 GLU   A CG  1 
ATOM   2249 C  CD  . GLU   A 1 366 ? -30.41442 -8.25645  -12.84307 1.000 24.62094 ? 366 GLU   A CD  1 
ATOM   2250 O  OE1 . GLU   A 1 366 ? -30.49742 -7.17984  -12.21513 1.000 27.21836 ? 366 GLU   A OE1 1 
ATOM   2251 O  OE2 . GLU   A 1 366 ? -31.39021 -8.78374  -13.41707 1.000 23.85802 ? 366 GLU   A OE2 1 
ATOM   2252 N  N   . LYS   A 1 367 ? -29.54212 -11.02014 -16.95822 1.000 21.63427 ? 367 LYS   A N   1 
ATOM   2253 C  CA  . LYS   A 1 367 ? -29.40198 -12.03552 -17.99570 1.000 25.63267 ? 367 LYS   A CA  1 
ATOM   2254 C  C   . LYS   A 1 367 ? -28.80974 -11.45588 -19.27387 1.000 21.13533 ? 367 LYS   A C   1 
ATOM   2255 O  O   . LYS   A 1 367 ? -28.03882 -12.13652 -19.96123 1.000 17.39557 ? 367 LYS   A O   1 
ATOM   2256 C  CB  . LYS   A 1 367 ? -30.75023 -12.68822 -18.28952 1.000 26.76483 ? 367 LYS   A CB  1 
ATOM   2257 C  CG  . LYS   A 1 367 ? -30.98271 -13.99437 -17.55467 1.000 34.44369 ? 367 LYS   A CG  1 
ATOM   2258 C  CD  . LYS   A 1 367 ? -31.71956 -15.00517 -18.42690 1.000 34.71329 ? 367 LYS   A CD  1 
ATOM   2259 C  CE  . LYS   A 1 367 ? -33.22376 -14.76971 -18.43673 1.000 29.81702 ? 367 LYS   A CE  1 
ATOM   2260 N  NZ  . LYS   A 1 367 ? -33.95760 -15.99328 -18.88050 1.000 34.94520 ? 367 LYS   A NZ  1 
ATOM   2261 N  N   . SER   A 1 368 ? -29.14650 -10.20715 -19.60571 1.000 19.22757 ? 368 SER   A N   1 
ATOM   2262 C  CA  . SER   A 1 368 ? -28.60872 -9.60891  -20.82270 1.000 23.61861 ? 368 SER   A CA  1 
ATOM   2263 C  C   . SER   A 1 368 ? -27.11777 -9.33004  -20.68684 1.000 18.00805 ? 368 SER   A C   1 
ATOM   2264 O  O   . SER   A 1 368 ? -26.36802 -9.46538  -21.65926 1.000 20.16012 ? 368 SER   A O   1 
ATOM   2265 C  CB  . SER   A 1 368 ? -29.37043 -8.32974  -21.16454 1.000 23.69674 ? 368 SER   A CB  1 
ATOM   2266 O  OG  . SER   A 1 368 ? -30.72521 -8.61516  -21.45969 1.000 26.40596 ? 368 SER   A OG  1 
ATOM   2267 N  N   . GLN   A 1 369 ? -26.66625 -8.94933  -19.48819 1.000 15.44707 ? 369 GLN   A N   1 
ATOM   2268 C  CA  . GLN   A 1 369 ? -25.23687 -8.73952  -19.27815 1.000 15.57649 ? 369 GLN   A CA  1 
ATOM   2269 C  C   . GLN   A 1 369 ? -24.46293 -10.04510 -19.40973 1.000 18.68961 ? 369 GLN   A C   1 
ATOM   2270 O  O   . GLN   A 1 369 ? -23.36849 -10.07045 -19.98494 1.000 19.86256 ? 369 GLN   A O   1 
ATOM   2271 C  CB  . GLN   A 1 369 ? -24.98798 -8.10090  -17.91145 1.000 16.11666 ? 369 GLN   A CB  1 
ATOM   2272 C  CG  . GLN   A 1 369 ? -25.32681 -6.61914  -17.85262 1.000 15.37815 ? 369 GLN   A CG  1 
ATOM   2273 C  CD  . GLN   A 1 369 ? -24.65250 -5.82480  -18.95861 1.000 16.14866 ? 369 GLN   A CD  1 
ATOM   2274 O  OE1 . GLN   A 1 369 ? -23.44125 -5.92053  -19.15816 1.000 15.01570 ? 369 GLN   A OE1 1 
ATOM   2275 N  NE2 . GLN   A 1 369 ? -25.43770 -5.03707  -19.68575 1.000 12.82851 ? 369 GLN   A NE2 1 
ATOM   2276 N  N   . VAL   A 1 370 ? -25.01596 -11.14130 -18.88598 1.000 18.81662 ? 370 VAL   A N   1 
ATOM   2277 C  CA  . VAL   A 1 370 ? -24.35150 -12.43706 -19.00361 1.000 19.31084 ? 370 VAL   A CA  1 
ATOM   2278 C  C   . VAL   A 1 370 ? -24.27155 -12.86047 -20.46503 1.000 17.72847 ? 370 VAL   A C   1 
ATOM   2279 O  O   . VAL   A 1 370 ? -23.22180 -13.30440 -20.94467 1.000 17.56248 ? 370 VAL   A O   1 
ATOM   2280 C  CB  . VAL   A 1 370 ? -25.07353 -13.49228 -18.14762 1.000 19.35074 ? 370 VAL   A CB  1 
ATOM   2281 C  CG1 . VAL   A 1 370 ? -24.42437 -14.85314 -18.33144 1.000 18.52386 ? 370 VAL   A CG1 1 
ATOM   2282 C  CG2 . VAL   A 1 370 ? -25.05212 -13.08677 -16.68512 1.000 19.41940 ? 370 VAL   A CG2 1 
ATOM   2283 N  N   . GLY   A 1 371 ? -25.38128 -12.73120 -21.19509 1.000 15.97662 ? 371 GLY   A N   1 
ATOM   2284 C  CA  . GLY   A 1 371 ? -25.35410 -13.04330 -22.61538 1.000 18.65887 ? 371 GLY   A CA  1 
ATOM   2285 C  C   . GLY   A 1 371 ? -24.41255 -12.13990 -23.38884 1.000 17.64359 ? 371 GLY   A C   1 
ATOM   2286 O  O   . GLY   A 1 371 ? -23.67872 -12.59745 -24.26856 1.000 19.89750 ? 371 GLY   A O   1 
ATOM   2287 N  N   . PHE   A 1 372 ? -24.41932 -10.84495 -23.06409 1.000 17.70195 ? 372 PHE   A N   1 
ATOM   2288 C  CA  . PHE   A 1 372 ? -23.51120 -9.89028  -23.69488 1.000 17.35925 ? 372 PHE   A CA  1 
ATOM   2289 C  C   . PHE   A 1 372 ? -22.05668 -10.30175 -23.49525 1.000 14.31776 ? 372 PHE   A C   1 
ATOM   2290 O  O   . PHE   A 1 372 ? -21.26415 -10.31023 -24.44428 1.000 17.60795 ? 372 PHE   A O   1 
ATOM   2291 C  CB  . PHE   A 1 372 ? -23.78409 -8.49693  -23.12088 1.000 16.57236 ? 372 PHE   A CB  1 
ATOM   2292 C  CG  . PHE   A 1 372 ? -22.92084 -7.40137  -23.68336 1.000 16.28384 ? 372 PHE   A CG  1 
ATOM   2293 C  CD1 . PHE   A 1 372 ? -22.76099 -7.24423  -25.05003 1.000 16.75892 ? 372 PHE   A CD1 1 
ATOM   2294 C  CD2 . PHE   A 1 372 ? -22.31968 -6.48447  -22.83303 1.000 15.82312 ? 372 PHE   A CD2 1 
ATOM   2295 C  CE1 . PHE   A 1 372 ? -21.98270 -6.21492  -25.55708 1.000 18.41978 ? 372 PHE   A CE1 1 
ATOM   2296 C  CE2 . PHE   A 1 372 ? -21.54555 -5.45186  -23.33135 1.000 18.18411 ? 372 PHE   A CE2 1 
ATOM   2297 C  CZ  . PHE   A 1 372 ? -21.37673 -5.31626  -24.69613 1.000 17.75945 ? 372 PHE   A CZ  1 
ATOM   2298 N  N   . ILE   A 1 373 ? -21.69234 -10.66465 -22.26405 1.000 17.25498 ? 373 ILE   A N   1 
ATOM   2299 C  CA  . ILE   A 1 373 ? -20.33087 -11.11999 -21.99165 1.000 15.03546 ? 373 ILE   A CA  1 
ATOM   2300 C  C   . ILE   A 1 373 ? -20.05436 -12.43412 -22.71330 1.000 17.88300 ? 373 ILE   A C   1 
ATOM   2301 O  O   . ILE   A 1 373 ? -19.02934 -12.58982 -23.38738 1.000 14.22396 ? 373 ILE   A O   1 
ATOM   2302 C  CB  . ILE   A 1 373 ? -20.10290 -11.25686 -20.47466 1.000 11.43412 ? 373 ILE   A CB  1 
ATOM   2303 C  CG1 . ILE   A 1 373 ? -20.15074 -9.88922  -19.79155 1.000 16.26938 ? 373 ILE   A CG1 1 
ATOM   2304 C  CG2 . ILE   A 1 373 ? -18.77568 -11.94259 -20.19112 1.000 16.09579 ? 373 ILE   A CG2 1 
ATOM   2305 C  CD1 . ILE   A 1 373 ? -20.11927 -9.96780  -18.27733 1.000 13.00420 ? 373 ILE   A CD1 1 
ATOM   2306 N  N   . ASP   A 1 374 ? -20.97325 -13.39631 -22.59137 1.000 16.97386 ? 374 ASP   A N   1 
ATOM   2307 C  CA  . ASP   A 1 374 ? -20.69983 -14.75027 -23.06741 1.000 20.46044 ? 374 ASP   A CA  1 
ATOM   2308 C  C   . ASP   A 1 374 ? -20.57181 -14.80846 -24.58482 1.000 18.93346 ? 374 ASP   A C   1 
ATOM   2309 O  O   . ASP   A 1 374 ? -19.71328 -15.52670 -25.11004 1.000 21.56962 ? 374 ASP   A O   1 
ATOM   2310 C  CB  . ASP   A 1 374 ? -21.79348 -15.70752 -22.59387 1.000 17.87044 ? 374 ASP   A CB  1 
ATOM   2311 C  CG  . ASP   A 1 374 ? -21.68329 -16.03444 -21.11979 1.000 16.01700 ? 374 ASP   A CG  1 
ATOM   2312 O  OD1 . ASP   A 1 374 ? -20.60062 -15.81014 -20.53953 1.000 17.61920 ? 374 ASP   A OD1 1 
ATOM   2313 O  OD2 . ASP   A 1 374 ? -22.67694 -16.52286 -20.54288 1.000 21.54683 ? 374 ASP   A OD2 1 
ATOM   2314 N  N   . TYR   A 1 375 ? -21.41401 -14.07183 -25.30745 1.000 13.51891 ? 375 TYR   A N   1 
ATOM   2315 C  CA  . TYR   A 1 375 ? -21.46285 -14.18205 -26.75881 1.000 17.87493 ? 375 TYR   A CA  1 
ATOM   2316 C  C   . TYR   A 1 375 ? -20.72970 -13.06169 -27.48635 1.000 21.38131 ? 375 TYR   A C   1 
ATOM   2317 O  O   . TYR   A 1 375 ? -20.50067 -13.18219 -28.69484 1.000 19.58981 ? 375 TYR   A O   1 
ATOM   2318 C  CB  . TYR   A 1 375 ? -22.92025 -14.23058 -27.23690 1.000 22.90342 ? 375 TYR   A CB  1 
ATOM   2319 C  CG  . TYR   A 1 375 ? -23.63483 -15.51897 -26.88780 1.000 22.31548 ? 375 TYR   A CG  1 
ATOM   2320 C  CD1 . TYR   A 1 375 ? -23.32747 -16.70410 -27.54418 1.000 27.22595 ? 375 TYR   A CD1 1 
ATOM   2321 C  CD2 . TYR   A 1 375 ? -24.62047 -15.54843 -25.90866 1.000 25.82054 ? 375 TYR   A CD2 1 
ATOM   2322 C  CE1 . TYR   A 1 375 ? -23.97664 -17.88409 -27.23237 1.000 28.11564 ? 375 TYR   A CE1 1 
ATOM   2323 C  CE2 . TYR   A 1 375 ? -25.27657 -16.72406 -25.59026 1.000 30.78640 ? 375 TYR   A CE2 1 
ATOM   2324 C  CZ  . TYR   A 1 375 ? -24.95021 -17.88829 -26.25522 1.000 32.70813 ? 375 TYR   A CZ  1 
ATOM   2325 O  OH  . TYR   A 1 375 ? -25.60027 -19.05976 -25.94165 1.000 36.43549 ? 375 TYR   A OH  1 
ATOM   2326 N  N   . ILE   A 1 376 ? -20.35033 -11.98673 -26.79579 1.000 18.51477 ? 376 ILE   A N   1 
ATOM   2327 C  CA  . ILE   A 1 376 ? -19.68451 -10.86777 -27.45578 1.000 17.62023 ? 376 ILE   A CA  1 
ATOM   2328 C  C   . ILE   A 1 376 ? -18.39052 -10.50209 -26.73864 1.000 16.27187 ? 376 ILE   A C   1 
ATOM   2329 O  O   . ILE   A 1 376 ? -17.29701 -10.65064 -27.29582 1.000 15.26260 ? 376 ILE   A O   1 
ATOM   2330 C  CB  . ILE   A 1 376 ? -20.61130 -9.64105  -27.54710 1.000 15.95522 ? 376 ILE   A CB  1 
ATOM   2331 C  CG1 . ILE   A 1 376 ? -21.89113 -9.98118  -28.31588 1.000 15.51034 ? 376 ILE   A CG1 1 
ATOM   2332 C  CG2 . ILE   A 1 376 ? -19.88642 -8.48341  -28.20901 1.000 11.52121 ? 376 ILE   A CG2 1 
ATOM   2333 C  CD1 . ILE   A 1 376 ? -21.66151 -10.33088 -29.77057 1.000 24.87915 ? 376 ILE   A CD1 1 
ATOM   2334 N  N   . VAL   A 1 377 ? -18.50630 -10.02655 -25.49645 1.000 12.53429 ? 377 VAL   A N   1 
ATOM   2335 C  CA  . VAL   A 1 377 ? -17.37857 -9.36717  -24.84249 1.000 15.51163 ? 377 VAL   A CA  1 
ATOM   2336 C  C   . VAL   A 1 377 ? -16.28363 -10.36577 -24.48906 1.000 14.79529 ? 377 VAL   A C   1 
ATOM   2337 O  O   . VAL   A 1 377 ? -15.09376 -10.09421 -24.69161 1.000 13.34749 ? 377 VAL   A O   1 
ATOM   2338 C  CB  . VAL   A 1 377 ? -17.86092 -8.59505  -23.60304 1.000 14.77519 ? 377 VAL   A CB  1 
ATOM   2339 C  CG1 . VAL   A 1 377 ? -16.70438 -7.84890  -22.95824 1.000 10.13244 ? 377 VAL   A CG1 1 
ATOM   2340 C  CG2 . VAL   A 1 377 ? -18.95444 -7.63536  -23.99358 1.000 11.44320 ? 377 VAL   A CG2 1 
ATOM   2341 N  N   . HIS   A 1 378 ? -16.65215 -11.52412 -23.94971 1.000 15.22337 ? 378 HIS   A N   1 
ATOM   2342 C  CA  . HIS   A 1 378 ? -15.60772 -12.46028 -23.55018 1.000 19.22464 ? 378 HIS   A CA  1 
ATOM   2343 C  C   . HIS   A 1 378 ? -14.92316 -13.10717 -24.75244 1.000 13.76114 ? 378 HIS   A C   1 
ATOM   2344 O  O   . HIS   A 1 378 ? -13.69501 -13.25248 -24.73212 1.000 17.25558 ? 378 HIS   A O   1 
ATOM   2345 C  CB  . HIS   A 1 378 ? -16.14489 -13.54323 -22.61228 1.000 14.19110 ? 378 HIS   A CB  1 
ATOM   2346 C  CG  . HIS   A 1 378 ? -15.06507 -14.31886 -21.92450 1.000 16.53651 ? 378 HIS   A CG  1 
ATOM   2347 N  ND1 . HIS   A 1 378 ? -14.39413 -15.35916 -22.53062 1.000 21.32421 ? 378 HIS   A ND1 1 
ATOM   2348 C  CD2 . HIS   A 1 378 ? -14.52086 -14.18798 -20.69164 1.000 16.79976 ? 378 HIS   A CD2 1 
ATOM   2349 C  CE1 . HIS   A 1 378 ? -13.49197 -15.84391 -21.69624 1.000 21.12998 ? 378 HIS   A CE1 1 
ATOM   2350 N  NE2 . HIS   A 1 378 ? -13.54833 -15.15081 -20.57335 1.000 21.02875 ? 378 HIS   A NE2 1 
ATOM   2351 N  N   . PRO   A 1 379 ? -15.64778 -13.52920 -25.80130 1.000 15.53795 ? 379 PRO   A N   1 
ATOM   2352 C  CA  . PRO   A 1 379 ? -14.93332 -14.02309 -26.99171 1.000 15.41416 ? 379 PRO   A CA  1 
ATOM   2353 C  C   . PRO   A 1 379 ? -13.96586 -13.00514 -27.56156 1.000 19.44343 ? 379 PRO   A C   1 
ATOM   2354 O  O   . PRO   A 1 379 ? -12.87454 -13.37376 -28.01222 1.000 17.40145 ? 379 PRO   A O   1 
ATOM   2355 C  CB  . PRO   A 1 379 ? -16.06735 -14.34254 -27.97362 1.000 18.69683 ? 379 PRO   A CB  1 
ATOM   2356 C  CG  . PRO   A 1 379 ? -17.21940 -14.66943 -27.10467 1.000 21.50281 ? 379 PRO   A CG  1 
ATOM   2357 C  CD  . PRO   A 1 379 ? -17.10365 -13.74099 -25.92763 1.000 15.07929 ? 379 PRO   A CD  1 
ATOM   2358 N  N   . LEU   A 1 380 ? -14.33643 -11.72446 -27.54280 1.000 14.66532 ? 380 LEU   A N   1 
ATOM   2359 C  CA  . LEU   A 1 380 ? -13.44071 -10.68376 -28.03345 1.000 15.27115 ? 380 LEU   A CA  1 
ATOM   2360 C  C   . LEU   A 1 380 ? -12.22954 -10.52379 -27.12247 1.000 14.97375 ? 380 LEU   A C   1 
ATOM   2361 O  O   . LEU   A 1 380 ? -11.08299 -10.57082 -27.58284 1.000 14.06320 ? 380 LEU   A O   1 
ATOM   2362 C  CB  . LEU   A 1 380 ? -14.20054 -9.36283  -28.15798 1.000 14.76526 ? 380 LEU   A CB  1 
ATOM   2363 C  CG  . LEU   A 1 380 ? -13.40283 -8.12545  -28.57212 1.000 18.34061 ? 380 LEU   A CG  1 
ATOM   2364 C  CD1 . LEU   A 1 380 ? -12.73616 -8.32448  -29.92341 1.000 13.15563 ? 380 LEU   A CD1 1 
ATOM   2365 C  CD2 . LEU   A 1 380 ? -14.30209 -6.89764  -28.58594 1.000 12.51236 ? 380 LEU   A CD2 1 
ATOM   2366 N  N   . TRP   A 1 381 ? -12.46478 -10.34181 -25.82102 1.000 13.01189 ? 381 TRP   A N   1 
ATOM   2367 C  CA  . TRP   A 1 381 ? -11.36843 -10.03407 -24.90882 1.000 15.19740 ? 381 TRP   A CA  1 
ATOM   2368 C  C   . TRP   A 1 381 ? -10.47164 -11.23848 -24.65813 1.000 18.11388 ? 381 TRP   A C   1 
ATOM   2369 O  O   . TRP   A 1 381 ? -9.27271  -11.07204 -24.40634 1.000 15.63364 ? 381 TRP   A O   1 
ATOM   2370 C  CB  . TRP   A 1 381 ? -11.92439 -9.48926  -23.59675 1.000 14.84499 ? 381 TRP   A CB  1 
ATOM   2371 C  CG  . TRP   A 1 381 ? -12.10943 -8.01673  -23.65743 1.000 15.58342 ? 381 TRP   A CG  1 
ATOM   2372 C  CD1 . TRP   A 1 381 ? -13.26235 -7.33999  -23.92908 1.000 14.67435 ? 381 TRP   A CD1 1 
ATOM   2373 C  CD2 . TRP   A 1 381 ? -11.09231 -7.02819  -23.48429 1.000 12.83261 ? 381 TRP   A CD2 1 
ATOM   2374 N  NE1 . TRP   A 1 381 ? -13.02704 -5.98560  -23.91689 1.000 13.40762 ? 381 TRP   A NE1 1 
ATOM   2375 C  CE2 . TRP   A 1 381 ? -11.70102 -5.76895  -23.64626 1.000 11.35942 ? 381 TRP   A CE2 1 
ATOM   2376 C  CE3 . TRP   A 1 381 ? -9.72520  -7.08634  -23.19877 1.000 10.31116 ? 381 TRP   A CE3 1 
ATOM   2377 C  CZ2 . TRP   A 1 381 ? -10.98984 -4.57710  -23.52990 1.000 10.78937 ? 381 TRP   A CZ2 1 
ATOM   2378 C  CZ3 . TRP   A 1 381 ? -9.02107  -5.90481  -23.08436 1.000 17.58661 ? 381 TRP   A CZ3 1 
ATOM   2379 C  CH2 . TRP   A 1 381 ? -9.65371  -4.66580  -23.24992 1.000 12.95788 ? 381 TRP   A CH2 1 
ATOM   2380 N  N   . GLU   A 1 382 ? -11.02681 -12.44938 -24.71318 1.000 17.86960 ? 382 GLU   A N   1 
ATOM   2381 C  CA  . GLU   A 1 382 ? -10.19351 -13.64341 -24.63394 1.000 21.34606 ? 382 GLU   A CA  1 
ATOM   2382 C  C   . GLU   A 1 382 ? -9.27144  -13.73984 -25.84217 1.000 21.20764 ? 382 GLU   A C   1 
ATOM   2383 O  O   . GLU   A 1 382 ? -8.11043  -14.14871 -25.71950 1.000 17.01293 ? 382 GLU   A O   1 
ATOM   2384 C  CB  . GLU   A 1 382 ? -11.08111 -14.88155 -24.52219 1.000 19.65099 ? 382 GLU   A CB  1 
ATOM   2385 C  CG  . GLU   A 1 382 ? -10.35562 -16.20768 -24.51025 1.000 29.15220 ? 382 GLU   A CG  1 
ATOM   2386 C  CD  . GLU   A 1 382 ? -11.32020 -17.36625 -24.36865 1.000 32.16492 ? 382 GLU   A CD  1 
ATOM   2387 O  OE1 . GLU   A 1 382 ? -12.40604 -17.30572 -24.98443 1.000 26.38341 ? 382 GLU   A OE1 1 
ATOM   2388 O  OE2 . GLU   A 1 382 ? -11.00074 -18.32835 -23.63933 1.000 40.64718 ? 382 GLU   A OE2 1 
ATOM   2389 N  N   . THR   A 1 383 ? -9.77014  -13.35504 -27.01937 1.000 16.55844 ? 383 THR   A N   1 
ATOM   2390 C  CA  . THR   A 1 383 ? -8.92472  -13.33536 -28.20739 1.000 17.94001 ? 383 THR   A CA  1 
ATOM   2391 C  C   . THR   A 1 383 ? -7.89740  -12.21216 -28.13281 1.000 19.83600 ? 383 THR   A C   1 
ATOM   2392 O  O   . THR   A 1 383 ? -6.73331  -12.40557 -28.50245 1.000 17.48705 ? 383 THR   A O   1 
ATOM   2393 C  CB  . THR   A 1 383 ? -9.78173  -13.19629 -29.46565 1.000 15.82224 ? 383 THR   A CB  1 
ATOM   2394 O  OG1 . THR   A 1 383 ? -10.77222 -14.23113 -29.48879 1.000 16.44024 ? 383 THR   A OG1 1 
ATOM   2395 C  CG2 . THR   A 1 383 ? -8.91753  -13.31509 -30.70937 1.000 15.47017 ? 383 THR   A CG2 1 
ATOM   2396 N  N   . TRP   A 1 384 ? -8.30402  -11.02924 -27.66157 1.000 17.77494 ? 384 TRP   A N   1 
ATOM   2397 C  CA  . TRP   A 1 384 ? -7.33362  -9.95439  -27.48026 1.000 16.93298 ? 384 TRP   A CA  1 
ATOM   2398 C  C   . TRP   A 1 384 ? -6.28666  -10.33417 -26.44439 1.000 19.07866 ? 384 TRP   A C   1 
ATOM   2399 O  O   . TRP   A 1 384 ? -5.09620  -10.04727 -26.61977 1.000 18.16136 ? 384 TRP   A O   1 
ATOM   2400 C  CB  . TRP   A 1 384 ? -8.02490  -8.65522  -27.07052 1.000 14.17785 ? 384 TRP   A CB  1 
ATOM   2401 C  CG  . TRP   A 1 384 ? -7.04475  -7.53403  -26.89954 1.000 12.77217 ? 384 TRP   A CG  1 
ATOM   2402 C  CD1 . TRP   A 1 384 ? -6.42478  -7.14823  -25.74407 1.000 14.95529 ? 384 TRP   A CD1 1 
ATOM   2403 C  CD2 . TRP   A 1 384 ? -6.54758  -6.67301  -27.92779 1.000 13.40417 ? 384 TRP   A CD2 1 
ATOM   2404 N  NE1 . TRP   A 1 384 ? -5.58207  -6.09043  -25.99058 1.000 11.45230 ? 384 TRP   A NE1 1 
ATOM   2405 C  CE2 . TRP   A 1 384 ? -5.63883  -5.78074  -27.32438 1.000 14.54975 ? 384 TRP   A CE2 1 
ATOM   2406 C  CE3 . TRP   A 1 384 ? -6.78825  -6.56563  -29.30064 1.000 13.09915 ? 384 TRP   A CE3 1 
ATOM   2407 C  CZ2 . TRP   A 1 384 ? -4.97165  -4.79403  -28.04745 1.000 16.47108 ? 384 TRP   A CZ2 1 
ATOM   2408 C  CZ3 . TRP   A 1 384 ? -6.12542  -5.58764  -30.01600 1.000 16.31896 ? 384 TRP   A CZ3 1 
ATOM   2409 C  CH2 . TRP   A 1 384 ? -5.22710  -4.71516  -29.38909 1.000 14.96669 ? 384 TRP   A CH2 1 
ATOM   2410 N  N   . ALA   A 1 385 ? -6.71485  -10.97048 -25.35093 1.000 20.11597 ? 385 ALA   A N   1 
ATOM   2411 C  CA  . ALA   A 1 385 ? -5.76530  -11.42049 -24.34006 1.000 20.70011 ? 385 ALA   A CA  1 
ATOM   2412 C  C   . ALA   A 1 385 ? -4.73645  -12.36768 -24.94054 1.000 21.43113 ? 385 ALA   A C   1 
ATOM   2413 O  O   . ALA   A 1 385 ? -3.53958  -12.25172 -24.65833 1.000 20.39565 ? 385 ALA   A O   1 
ATOM   2414 C  CB  . ALA   A 1 385 ? -6.50386  -12.09159 -23.18196 1.000 14.39248 ? 385 ALA   A CB  1 
ATOM   2415 N  N   . ASP   A 1 386 ? -5.18241  -13.30197 -25.78510 1.000 20.66647 ? 386 ASP   A N   1 
ATOM   2416 C  CA  . ASP   A 1 386 ? -4.24798  -14.21096 -26.44232 1.000 24.63430 ? 386 ASP   A CA  1 
ATOM   2417 C  C   . ASP   A 1 386 ? -3.26585  -13.45304 -27.32652 1.000 25.24561 ? 386 ASP   A C   1 
ATOM   2418 O  O   . ASP   A 1 386 ? -2.08031  -13.79989 -27.38698 1.000 20.03928 ? 386 ASP   A O   1 
ATOM   2419 C  CB  . ASP   A 1 386 ? -5.00874  -15.25097 -27.26511 1.000 23.37985 ? 386 ASP   A CB  1 
ATOM   2420 C  CG  . ASP   A 1 386 ? -5.61231  -16.34557 -26.41022 1.000 31.85785 ? 386 ASP   A CG  1 
ATOM   2421 O  OD1 . ASP   A 1 386 ? -5.22007  -16.46726 -25.23051 1.000 32.82680 ? 386 ASP   A OD1 1 
ATOM   2422 O  OD2 . ASP   A 1 386 ? -6.47430  -17.09014 -26.92283 1.000 35.19798 ? 386 ASP   A OD2 1 
ATOM   2423 N  N   . LEU   A 1 387 ? -3.73897  -12.41112 -28.01620 1.000 23.38591 ? 387 LEU   A N   1 
ATOM   2424 C  CA  . LEU   A 1 387 ? -2.86482  -11.65681 -28.90994 1.000 22.00594 ? 387 LEU   A CA  1 
ATOM   2425 C  C   . LEU   A 1 387 ? -1.71891  -11.00293 -28.14767 1.000 19.74496 ? 387 LEU   A C   1 
ATOM   2426 O  O   . LEU   A 1 387 ? -0.58803  -10.94120 -28.64418 1.000 27.74024 ? 387 LEU   A O   1 
ATOM   2427 C  CB  . LEU   A 1 387 ? -3.66867  -10.59841 -29.66588 1.000 20.95196 ? 387 LEU   A CB  1 
ATOM   2428 C  CG  . LEU   A 1 387 ? -2.85500  -9.73976  -30.63815 1.000 21.67669 ? 387 LEU   A CG  1 
ATOM   2429 C  CD1 . LEU   A 1 387 ? -2.51087  -10.52968 -31.89364 1.000 22.90604 ? 387 LEU   A CD1 1 
ATOM   2430 C  CD2 . LEU   A 1 387 ? -3.58036  -8.44757  -30.98423 1.000 19.90415 ? 387 LEU   A CD2 1 
ATOM   2431 N  N   . VAL   A 1 388 ? -1.98792  -10.51626 -26.94063 1.000 21.31702 ? 388 VAL   A N   1 
ATOM   2432 C  CA  . VAL   A 1 388 ? -1.00747  -9.77787  -26.15769 1.000 21.60666 ? 388 VAL   A CA  1 
ATOM   2433 C  C   . VAL   A 1 388 ? -0.60473  -10.54571 -24.89873 1.000 23.93005 ? 388 VAL   A C   1 
ATOM   2434 O  O   . VAL   A 1 388 ? -0.05887  -9.95973  -23.96749 1.000 20.38360 ? 388 VAL   A O   1 
ATOM   2435 C  CB  . VAL   A 1 388 ? -1.52645  -8.37349  -25.80789 1.000 21.84425 ? 388 VAL   A CB  1 
ATOM   2436 C  CG1 . VAL   A 1 388 ? -1.95655  -7.63757  -27.06770 1.000 20.76156 ? 388 VAL   A CG1 1 
ATOM   2437 C  CG2 . VAL   A 1 388 ? -2.68643  -8.46594  -24.82179 1.000 19.76323 ? 388 VAL   A CG2 1 
ATOM   2438 N  N   . HIS   A 1 389 ? -0.86459  -11.84954 -24.86230 1.000 23.83965 ? 389 HIS   A N   1 
ATOM   2439 C  CA  . HIS   A 1 389 ? -0.63755  -12.66947 -23.67244 1.000 24.29569 ? 389 HIS   A CA  1 
ATOM   2440 C  C   . HIS   A 1 389 ? 0.79131   -12.53365 -23.14746 1.000 28.71280 ? 389 HIS   A C   1 
ATOM   2441 O  O   . HIS   A 1 389 ? 1.74989   -12.63945 -23.91282 1.000 27.97661 ? 389 HIS   A O   1 
ATOM   2442 C  CB  . HIS   A 1 389 ? -0.95467  -14.13294 -23.99032 1.000 29.08586 ? 389 HIS   A CB  1 
ATOM   2443 C  CG  . HIS   A 1 389 ? -1.12962  -14.99594 -22.78030 1.000 34.38737 ? 389 HIS   A CG  1 
ATOM   2444 N  ND1 . HIS   A 1 389 ? -2.35332  -15.20462 -22.18145 1.000 36.92830 ? 389 HIS   A ND1 1 
ATOM   2445 C  CD2 . HIS   A 1 389 ? -0.23472  -15.71032 -22.06143 1.000 35.04562 ? 389 HIS   A CD2 1 
ATOM   2446 C  CE1 . HIS   A 1 389 ? -2.20217  -16.01085 -21.14535 1.000 40.38247 ? 389 HIS   A CE1 1 
ATOM   2447 N  NE2 . HIS   A 1 389 ? -0.92491  -16.33034 -21.04954 1.000 39.26383 ? 389 HIS   A NE2 1 
ATOM   2448 N  N   . PRO   A 1 390 ? 0.94085   -12.31516 -21.83092 1.000 24.95964 ? 390 PRO   A N   1 
ATOM   2449 C  CA  . PRO   A 1 390 ? -0.09633  -12.31294 -20.79558 1.000 26.84086 ? 390 PRO   A CA  1 
ATOM   2450 C  C   . PRO   A 1 390 ? -0.56491  -10.92490 -20.36355 1.000 21.80852 ? 390 PRO   A C   1 
ATOM   2451 O  O   . PRO   A 1 390 ? -1.15971  -10.80836 -19.29006 1.000 20.07781 ? 390 PRO   A O   1 
ATOM   2452 C  CB  . PRO   A 1 390 ? 0.61429   -12.99524 -19.63395 1.000 29.20250 ? 390 PRO   A CB  1 
ATOM   2453 C  CG  . PRO   A 1 390 ? 2.02116   -12.43959 -19.74391 1.000 26.75313 ? 390 PRO   A CG  1 
ATOM   2454 C  CD  . PRO   A 1 390 ? 2.28182   -12.20567 -21.22950 1.000 29.55366 ? 390 PRO   A CD  1 
ATOM   2455 N  N   . ASP   A 1 391 ? -0.30340  -9.90520  -21.18684 1.000 22.09791 ? 391 ASP   A N   1 
ATOM   2456 C  CA  . ASP   A 1 391 ? -0.46459  -8.51878  -20.75092 1.000 24.64934 ? 391 ASP   A CA  1 
ATOM   2457 C  C   . ASP   A 1 391 ? -1.84771  -8.24203  -20.17245 1.000 20.43997 ? 391 ASP   A C   1 
ATOM   2458 O  O   . ASP   A 1 391 ? -1.98928  -7.44270  -19.23978 1.000 20.23533 ? 391 ASP   A O   1 
ATOM   2459 C  CB  . ASP   A 1 391 ? -0.20196  -7.56728  -21.91634 1.000 24.42708 ? 391 ASP   A CB  1 
ATOM   2460 C  CG  . ASP   A 1 391 ? 1.21650   -7.64351  -22.43489 1.000 28.26462 ? 391 ASP   A CG  1 
ATOM   2461 O  OD1 . ASP   A 1 391 ? 2.02758   -8.39520  -21.85702 1.000 27.18967 ? 391 ASP   A OD1 1 
ATOM   2462 O  OD2 . ASP   A 1 391 ? 1.51983   -6.93683  -23.41927 1.000 27.46135 ? 391 ASP   A OD2 1 
ATOM   2463 N  N   . ALA   A 1 392 ? -2.88022  -8.88911  -20.71061 1.000 19.50662 ? 392 ALA   A N   1 
ATOM   2464 C  CA  . ALA   A 1 392 ? -4.26041  -8.54167  -20.40261 1.000 19.30382 ? 392 ALA   A CA  1 
ATOM   2465 C  C   . ALA   A 1 392 ? -4.92766  -9.52437  -19.44533 1.000 20.13345 ? 392 ALA   A C   1 
ATOM   2466 O  O   . ALA   A 1 392 ? -6.16102  -9.58452  -19.39614 1.000 15.06923 ? 392 ALA   A O   1 
ATOM   2467 C  CB  . ALA   A 1 392 ? -5.07076  -8.43820  -21.69517 1.000 18.01018 ? 392 ALA   A CB  1 
ATOM   2468 N  N   . GLN   A 1 393 ? -4.14660  -10.28333 -18.67297 1.000 17.72306 ? 393 GLN   A N   1 
ATOM   2469 C  CA  . GLN   A 1 393 ? -4.74090  -11.32823 -17.84394 1.000 22.72002 ? 393 GLN   A CA  1 
ATOM   2470 C  C   . GLN   A 1 393 ? -5.59603  -10.74225 -16.72504 1.000 21.58123 ? 393 GLN   A C   1 
ATOM   2471 O  O   . GLN   A 1 393 ? -6.65494  -11.29082 -16.39862 1.000 21.97565 ? 393 GLN   A O   1 
ATOM   2472 C  CB  . GLN   A 1 393 ? -3.65259  -12.23461 -17.27035 1.000 24.76393 ? 393 GLN   A CB  1 
ATOM   2473 C  CG  . GLN   A 1 393 ? -4.20037  -13.46175 -16.55956 1.000 25.49178 ? 393 GLN   A CG  1 
ATOM   2474 C  CD  . GLN   A 1 393 ? -5.00901  -14.35339 -17.48293 1.000 30.46248 ? 393 GLN   A CD  1 
ATOM   2475 O  OE1 . GLN   A 1 393 ? -4.54957  -14.72844 -18.56165 1.000 38.55768 ? 393 GLN   A OE1 1 
ATOM   2476 N  NE2 . GLN   A 1 393 ? -6.22467  -14.68950 -17.06686 1.000 30.83217 ? 393 GLN   A NE2 1 
ATOM   2477 N  N   . ASP   A 1 394 ? -5.16032  -9.63150  -16.12458 1.000 18.14660 ? 394 ASP   A N   1 
ATOM   2478 C  CA  . ASP   A 1 394 ? -5.95269  -9.02237  -15.05934 1.000 22.02487 ? 394 ASP   A CA  1 
ATOM   2479 C  C   . ASP   A 1 394 ? -7.27059  -8.47836  -15.59607 1.000 18.85725 ? 394 ASP   A C   1 
ATOM   2480 O  O   . ASP   A 1 394 ? -8.31380  -8.60445  -14.94353 1.000 23.06560 ? 394 ASP   A O   1 
ATOM   2481 C  CB  . ASP   A 1 394 ? -5.15629  -7.91456  -14.37021 1.000 21.55850 ? 394 ASP   A CB  1 
ATOM   2482 C  CG  . ASP   A 1 394 ? -3.91796  -8.43574  -13.66877 1.000 33.73524 ? 394 ASP   A CG  1 
ATOM   2483 O  OD1 . ASP   A 1 394 ? -3.82467  -9.66271  -13.45271 1.000 29.24737 ? 394 ASP   A OD1 1 
ATOM   2484 O  OD2 . ASP   A 1 394 ? -3.04064  -7.61527  -13.32615 1.000 35.09618 ? 394 ASP   A OD2 1 
ATOM   2485 N  N   . ILE   A 1 395 ? -7.24127  -7.86985  -16.78319 1.000 18.01381 ? 395 ILE   A N   1 
ATOM   2486 C  CA  . ILE   A 1 395 ? -8.47131  -7.39790  -17.41201 1.000 16.87941 ? 395 ILE   A CA  1 
ATOM   2487 C  C   . ILE   A 1 395 ? -9.39883  -8.56822  -17.71113 1.000 15.10162 ? 395 ILE   A C   1 
ATOM   2488 O  O   . ILE   A 1 395 ? -10.61104 -8.49818  -17.47128 1.000 10.28001 ? 395 ILE   A O   1 
ATOM   2489 C  CB  . ILE   A 1 395 ? -8.14049  -6.59605  -18.68381 1.000 16.32763 ? 395 ILE   A CB  1 
ATOM   2490 C  CG1 . ILE   A 1 395 ? -7.39455  -5.31193  -18.32431 1.000 20.16507 ? 395 ILE   A CG1 1 
ATOM   2491 C  CG2 . ILE   A 1 395 ? -9.39876  -6.27997  -19.46596 1.000 10.96509 ? 395 ILE   A CG2 1 
ATOM   2492 C  CD1 . ILE   A 1 395 ? -6.92483  -4.53223  -19.53117 1.000 19.94466 ? 395 ILE   A CD1 1 
ATOM   2493 N  N   . LEU   A 1 396 ? -8.84475  -9.66225  -18.24049 1.000 16.38323 ? 396 LEU   A N   1 
ATOM   2494 C  CA  . LEU   A 1 396 ? -9.65341  -10.84580 -18.51437 1.000 18.41956 ? 396 LEU   A CA  1 
ATOM   2495 C  C   . LEU   A 1 396 ? -10.17693 -11.46449 -17.22347 1.000 15.50126 ? 396 LEU   A C   1 
ATOM   2496 O  O   . LEU   A 1 396 ? -11.32324 -11.92615 -17.17091 1.000 18.54779 ? 396 LEU   A O   1 
ATOM   2497 C  CB  . LEU   A 1 396 ? -8.83574  -11.86347 -19.31154 1.000 16.12649 ? 396 LEU   A CB  1 
ATOM   2498 C  CG  . LEU   A 1 396 ? -9.56818  -13.10192 -19.82990 1.000 24.18877 ? 396 LEU   A CG  1 
ATOM   2499 C  CD1 . LEU   A 1 396 ? -10.65973 -12.69936 -20.80399 1.000 15.32723 ? 396 LEU   A CD1 1 
ATOM   2500 C  CD2 . LEU   A 1 396 ? -8.59626  -14.06494 -20.49163 1.000 23.02006 ? 396 LEU   A CD2 1 
ATOM   2501 N  N   . ASP   A 1 397 ? -9.35132  -11.47998 -16.17248 1.000 18.38358 ? 397 ASP   A N   1 
ATOM   2502 C  CA  . ASP   A 1 397 ? -9.80063  -11.97722 -14.87472 1.000 21.60576 ? 397 ASP   A CA  1 
ATOM   2503 C  C   . ASP   A 1 397 ? -10.97094 -11.15651 -14.34935 1.000 19.64123 ? 397 ASP   A C   1 
ATOM   2504 O  O   . ASP   A 1 397 ? -11.97076 -11.70987 -13.87645 1.000 17.21015 ? 397 ASP   A O   1 
ATOM   2505 C  CB  . ASP   A 1 397 ? -8.64680  -11.95759 -13.87028 1.000 19.79620 ? 397 ASP   A CB  1 
ATOM   2506 C  CG  . ASP   A 1 397 ? -7.64092  -13.06285 -14.11186 1.000 25.69462 ? 397 ASP   A CG  1 
ATOM   2507 O  OD1 . ASP   A 1 397 ? -7.98491  -14.03854 -14.81171 1.000 22.04729 ? 397 ASP   A OD1 1 
ATOM   2508 O  OD2 . ASP   A 1 397 ? -6.51025  -12.95948 -13.58935 1.000 25.82395 ? 397 ASP   A OD2 1 
ATOM   2509 N  N   . THR   A 1 398 ? -10.85814 -9.82774  -14.41884 1.000 14.74638 ? 398 THR   A N   1 
ATOM   2510 C  CA  . THR   A 1 398 ? -11.93616 -8.96306  -13.94917 1.000 16.63928 ? 398 THR   A CA  1 
ATOM   2511 C  C   . THR   A 1 398 ? -13.22030 -9.22519  -14.72438 1.000 15.06878 ? 398 THR   A C   1 
ATOM   2512 O  O   . THR   A 1 398 ? -14.30495 -9.32398  -14.13881 1.000 15.89990 ? 398 THR   A O   1 
ATOM   2513 C  CB  . THR   A 1 398 ? -11.52726 -7.49492  -14.07513 1.000 16.02822 ? 398 THR   A CB  1 
ATOM   2514 O  OG1 . THR   A 1 398 ? -10.26921 -7.28576  -13.42137 1.000 15.66433 ? 398 THR   A OG1 1 
ATOM   2515 C  CG2 . THR   A 1 398 ? -12.57544 -6.59810  -13.43583 1.000 16.98971 ? 398 THR   A CG2 1 
ATOM   2516 N  N   . LEU   A 1 399 ? -13.11174 -9.34060  -16.05034 1.000 16.60747 ? 399 LEU   A N   1 
ATOM   2517 C  CA  . LEU   A 1 399 ? -14.27262 -9.65170  -16.87764 1.000 15.69172 ? 399 LEU   A CA  1 
ATOM   2518 C  C   . LEU   A 1 399 ? -14.94927 -10.93685 -16.41821 1.000 18.21727 ? 399 LEU   A C   1 
ATOM   2519 O  O   . LEU   A 1 399 ? -16.17888 -11.00229 -16.30504 1.000 11.51034 ? 399 LEU   A O   1 
ATOM   2520 C  CB  . LEU   A 1 399 ? -13.85083 -9.76519  -18.34309 1.000 12.68658 ? 399 LEU   A CB  1 
ATOM   2521 C  CG  . LEU   A 1 399 ? -14.93382 -10.26308 -19.30061 1.000 10.60464 ? 399 LEU   A CG  1 
ATOM   2522 C  CD1 . LEU   A 1 399 ? -16.10202 -9.29833  -19.31281 1.000 7.80528  ? 399 LEU   A CD1 1 
ATOM   2523 C  CD2 . LEU   A 1 399 ? -14.37992 -10.45657 -20.70295 1.000 12.51688 ? 399 LEU   A CD2 1 
ATOM   2524 N  N   . GLU   A 1 400 ? -14.15464 -11.97313 -16.14385 1.000 16.76472 ? 400 GLU   A N   1 
ATOM   2525 C  CA  . GLU   A 1 400 ? -14.72901 -13.24896 -15.73181 1.000 19.76360 ? 400 GLU   A CA  1 
ATOM   2526 C  C   . GLU   A 1 400 ? -15.31061 -13.16787 -14.32510 1.000 14.49223 ? 400 GLU   A C   1 
ATOM   2527 O  O   . GLU   A 1 400 ? -16.33177 -13.80219 -14.03575 1.000 19.32711 ? 400 GLU   A O   1 
ATOM   2528 C  CB  . GLU   A 1 400 ? -13.67536 -14.35229 -15.83801 1.000 17.88402 ? 400 GLU   A CB  1 
ATOM   2529 C  CG  . GLU   A 1 400 ? -13.40532 -14.77181 -17.27841 1.000 23.11879 ? 400 GLU   A CG  1 
ATOM   2530 C  CD  . GLU   A 1 400 ? -12.13987 -15.59073 -17.43806 1.000 28.70526 ? 400 GLU   A CD  1 
ATOM   2531 O  OE1 . GLU   A 1 400 ? -11.73606 -15.83823 -18.59492 1.000 21.62216 ? 400 GLU   A OE1 1 
ATOM   2532 O  OE2 . GLU   A 1 400 ? -11.54819 -15.98371 -16.41136 1.000 27.16115 ? 400 GLU   A OE2 1 
ATOM   2533 N  N   . ASP   A 1 401 ? -14.68515 -12.38661 -13.44016 1.000 15.09252 ? 401 ASP   A N   1 
ATOM   2534 C  CA  . ASP   A 1 401 ? -15.27627 -12.14032 -12.12752 1.000 14.67696 ? 401 ASP   A CA  1 
ATOM   2535 C  C   . ASP   A 1 401 ? -16.61079 -11.41722 -12.25912 1.000 19.37248 ? 401 ASP   A C   1 
ATOM   2536 O  O   . ASP   A 1 401 ? -17.60094 -11.79155 -11.61952 1.000 17.15563 ? 401 ASP   A O   1 
ATOM   2537 C  CB  . ASP   A 1 401 ? -14.31819 -11.32963 -11.25331 1.000 16.73762 ? 401 ASP   A CB  1 
ATOM   2538 C  CG  . ASP   A 1 401 ? -13.16036 -12.15475 -10.73035 1.000 20.32551 ? 401 ASP   A CG  1 
ATOM   2539 O  OD1 . ASP   A 1 401 ? -13.15896 -13.38505 -10.94181 1.000 21.23771 ? 401 ASP   A OD1 1 
ATOM   2540 O  OD2 . ASP   A 1 401 ? -12.25910 -11.57227 -10.09068 1.000 22.58940 ? 401 ASP   A OD2 1 
ATOM   2541 N  N   . ASN   A 1 402 ? -16.65296 -10.37005 -13.08753 1.000 14.89645 ? 402 ASN   A N   1 
ATOM   2542 C  CA  . ASN   A 1 402 ? -17.89064 -9.61854  -13.26990 1.000 16.26469 ? 402 ASN   A CA  1 
ATOM   2543 C  C   . ASN   A 1 402 ? -18.97188 -10.48221 -13.90644 1.000 15.70130 ? 402 ASN   A C   1 
ATOM   2544 O  O   . ASN   A 1 402 ? -20.15227 -10.36925 -13.55491 1.000 14.64142 ? 402 ASN   A O   1 
ATOM   2545 C  CB  . ASN   A 1 402 ? -17.62937 -8.37143  -14.11503 1.000 14.72955 ? 402 ASN   A CB  1 
ATOM   2546 C  CG  . ASN   A 1 402 ? -16.79880 -7.33356  -13.38298 1.000 18.43467 ? 402 ASN   A CG  1 
ATOM   2547 O  OD1 . ASN   A 1 402 ? -16.66758 -7.37738  -12.15962 1.000 15.97193 ? 402 ASN   A OD1 1 
ATOM   2548 N  ND2 . ASN   A 1 402 ? -16.23872 -6.38808  -14.13004 1.000 16.82229 ? 402 ASN   A ND2 1 
ATOM   2549 N  N   . ARG   A 1 403 ? -18.59007 -11.34374 -14.85320 1.000 16.51571 ? 403 ARG   A N   1 
ATOM   2550 C  CA  . ARG   A 1 403 ? -19.53927 -12.30422 -15.40761 1.000 16.60713 ? 403 ARG   A CA  1 
ATOM   2551 C  C   . ARG   A 1 403 ? -20.09847 -13.19802 -14.30910 1.000 18.01636 ? 403 ARG   A C   1 
ATOM   2552 O  O   . ARG   A 1 403 ? -21.31314 -13.41586 -14.22405 1.000 18.58173 ? 403 ARG   A O   1 
ATOM   2553 C  CB  . ARG   A 1 403 ? -18.86212 -13.14054 -16.49620 1.000 15.93174 ? 403 ARG   A CB  1 
ATOM   2554 C  CG  . ARG   A 1 403 ? -19.81895 -13.93377 -17.37961 1.000 23.01986 ? 403 ARG   A CG  1 
ATOM   2555 C  CD  . ARG   A 1 403 ? -20.09431 -15.32759 -16.83735 1.000 19.66723 ? 403 ARG   A CD  1 
ATOM   2556 N  NE  . ARG   A 1 403 ? -21.03844 -16.05358 -17.68116 1.000 23.24520 ? 403 ARG   A NE  1 
ATOM   2557 C  CZ  . ARG   A 1 403 ? -21.72009 -17.12425 -17.28877 1.000 22.31984 ? 403 ARG   A CZ  1 
ATOM   2558 N  NH1 . ARG   A 1 403 ? -21.56494 -17.59621 -16.05954 1.000 19.92877 ? 403 ARG   A NH1 1 
ATOM   2559 N  NH2 . ARG   A 1 403 ? -22.55894 -17.72174 -18.12422 1.000 16.79690 ? 403 ARG   A NH2 1 
ATOM   2560 N  N   . GLU   A 1 404 ? -19.21471 -13.72749 -13.45942 1.000 19.34238 ? 404 GLU   A N   1 
ATOM   2561 C  CA  . GLU   A 1 404 ? -19.64338 -14.50490 -12.30181 1.000 24.29468 ? 404 GLU   A CA  1 
ATOM   2562 C  C   . GLU   A 1 404 ? -20.65117 -13.73371 -11.46031 1.000 26.30274 ? 404 GLU   A C   1 
ATOM   2563 O  O   . GLU   A 1 404 ? -21.70813 -14.26098 -11.09457 1.000 22.55401 ? 404 GLU   A O   1 
ATOM   2564 C  CB  . GLU   A 1 404 ? -18.42800 -14.88457 -11.45276 1.000 23.69221 ? 404 GLU   A CB  1 
ATOM   2565 C  CG  . GLU   A 1 404 ? -18.03609 -16.34967 -11.50851 1.000 40.24073 ? 404 GLU   A CG  1 
ATOM   2566 C  CD  . GLU   A 1 404 ? -19.09578 -17.26646 -10.92370 1.000 52.67306 ? 404 GLU   A CD  1 
ATOM   2567 O  OE1 . GLU   A 1 404 ? -19.08077 -18.47148 -11.25232 1.000 55.98792 ? 404 GLU   A OE1 1 
ATOM   2568 O  OE2 . GLU   A 1 404 ? -19.94042 -16.78755 -10.13562 1.000 53.43264 ? 404 GLU   A OE2 1 
ATOM   2569 N  N   . TRP   A 1 405 ? -20.33929 -12.47261 -11.15138 1.000 19.68281 ? 405 TRP   A N   1 
ATOM   2570 C  CA  . TRP   A 1 405 ? -21.18146 -11.70140 -10.24320 1.000 14.97416 ? 405 TRP   A CA  1 
ATOM   2571 C  C   . TRP   A 1 405 ? -22.57447 -11.49113 -10.82141 1.000 17.54392 ? 405 TRP   A C   1 
ATOM   2572 O  O   . TRP   A 1 405 ? -23.58015 -11.69642 -10.13246 1.000 19.45428 ? 405 TRP   A O   1 
ATOM   2573 C  CB  . TRP   A 1 405 ? -20.52919 -10.35759 -9.92385  1.000 15.41069 ? 405 TRP   A CB  1 
ATOM   2574 C  CG  . TRP   A 1 405 ? -21.32833 -9.56548  -8.94204  1.000 19.27733 ? 405 TRP   A CG  1 
ATOM   2575 C  CD1 . TRP   A 1 405 ? -21.22515 -9.60290  -7.58210  1.000 15.09875 ? 405 TRP   A CD1 1 
ATOM   2576 C  CD2 . TRP   A 1 405 ? -22.37385 -8.63272  -9.24020  1.000 16.07956 ? 405 TRP   A CD2 1 
ATOM   2577 N  NE1 . TRP   A 1 405 ? -22.13474 -8.74388  -7.01516  1.000 17.35849 ? 405 TRP   A NE1 1 
ATOM   2578 C  CE2 . TRP   A 1 405 ? -22.85228 -8.13625  -8.01188  1.000 13.20322 ? 405 TRP   A CE2 1 
ATOM   2579 C  CE3 . TRP   A 1 405 ? -22.94797 -8.16520  -10.42693 1.000 17.53669 ? 405 TRP   A CE3 1 
ATOM   2580 C  CZ2 . TRP   A 1 405 ? -23.87731 -7.19605  -7.93549  1.000 15.68072 ? 405 TRP   A CZ2 1 
ATOM   2581 C  CZ3 . TRP   A 1 405 ? -23.96583 -7.23109  -10.34906 1.000 14.81417 ? 405 TRP   A CZ3 1 
ATOM   2582 C  CH2 . TRP   A 1 405 ? -24.41954 -6.75686  -9.11202  1.000 16.42399 ? 405 TRP   A CH2 1 
ATOM   2583 N  N   . TYR   A 1 406 ? -22.65523 -11.06782 -12.08512 1.000 15.17840 ? 406 TYR   A N   1 
ATOM   2584 C  CA  . TYR   A 1 406 ? -23.96204 -10.86048 -12.70067 1.000 18.76278 ? 406 TYR   A CA  1 
ATOM   2585 C  C   . TYR   A 1 406 ? -24.75153 -12.16023 -12.76870 1.000 15.94139 ? 406 TYR   A C   1 
ATOM   2586 O  O   . TYR   A 1 406 ? -25.96480 -12.17144 -12.52901 1.000 18.05132 ? 406 TYR   A O   1 
ATOM   2587 C  CB  . TYR   A 1 406 ? -23.80257 -10.25127 -14.09246 1.000 16.06575 ? 406 TYR   A CB  1 
ATOM   2588 C  CG  . TYR   A 1 406 ? -24.00381 -8.75572  -14.10765 1.000 16.64946 ? 406 TYR   A CG  1 
ATOM   2589 C  CD1 . TYR   A 1 406 ? -25.26807 -8.20894  -13.92730 1.000 15.77786 ? 406 TYR   A CD1 1 
ATOM   2590 C  CD2 . TYR   A 1 406 ? -22.93401 -7.89051  -14.29444 1.000 12.63504 ? 406 TYR   A CD2 1 
ATOM   2591 C  CE1 . TYR   A 1 406 ? -25.46263 -6.84353  -13.93542 1.000 13.04688 ? 406 TYR   A CE1 1 
ATOM   2592 C  CE2 . TYR   A 1 406 ? -23.11897 -6.52159  -14.30380 1.000 14.34182 ? 406 TYR   A CE2 1 
ATOM   2593 C  CZ  . TYR   A 1 406 ? -24.38379 -6.00440  -14.12447 1.000 14.87736 ? 406 TYR   A CZ  1 
ATOM   2594 O  OH  . TYR   A 1 406 ? -24.57074 -4.64244  -14.13409 1.000 14.10601 ? 406 TYR   A OH  1 
ATOM   2595 N  N   . GLN   A 1 407 ? -24.07786 -13.26688 -13.08813 1.000 15.44137 ? 407 GLN   A N   1 
ATOM   2596 C  CA  . GLN   A 1 407 ? -24.74225 -14.56547 -13.09005 1.000 23.84057 ? 407 GLN   A CA  1 
ATOM   2597 C  C   . GLN   A 1 407 ? -25.29224 -14.90632 -11.71022 1.000 24.02421 ? 407 GLN   A C   1 
ATOM   2598 O  O   . GLN   A 1 407 ? -26.40137 -15.44018 -11.58993 1.000 21.93292 ? 407 GLN   A O   1 
ATOM   2599 C  CB  . GLN   A 1 407 ? -23.76773 -15.64447 -13.56239 1.000 20.57722 ? 407 GLN   A CB  1 
ATOM   2600 C  CG  . GLN   A 1 407 ? -24.31935 -17.05772 -13.51523 1.000 22.34286 ? 407 GLN   A CG  1 
ATOM   2601 C  CD  . GLN   A 1 407 ? -25.39112 -17.30584 -14.55587 1.000 26.04867 ? 407 GLN   A CD  1 
ATOM   2602 O  OE1 . GLN   A 1 407 ? -25.54543 -16.53653 -15.50435 1.000 26.51026 ? 407 GLN   A OE1 1 
ATOM   2603 N  NE2 . GLN   A 1 407 ? -26.13434 -18.39139 -14.38759 1.000 30.16048 ? 407 GLN   A NE2 1 
ATOM   2604 N  N   . SER   A 1 408 ? -24.53729 -14.58669 -10.65507 1.000 17.32631 ? 408 SER   A N   1 
ATOM   2605 C  CA  . SER   A 1 408 ? -24.94728 -14.93713 -9.29919  1.000 17.74309 ? 408 SER   A CA  1 
ATOM   2606 C  C   . SER   A 1 408 ? -26.23011 -14.23465 -8.87360  1.000 24.03765 ? 408 SER   A C   1 
ATOM   2607 O  O   . SER   A 1 408 ? -26.88789 -14.68908 -7.93111  1.000 27.66491 ? 408 SER   A O   1 
ATOM   2608 C  CB  . SER   A 1 408 ? -23.82922 -14.60490 -8.31040  1.000 19.73188 ? 408 SER   A CB  1 
ATOM   2609 O  OG  . SER   A 1 408 ? -23.79157 -13.21484 -8.03494  1.000 16.53385 ? 408 SER   A OG  1 
ATOM   2610 N  N   . THR   A 1 409 ? -26.59936 -13.14247 -9.53695  1.000 23.98892 ? 409 THR   A N   1 
ATOM   2611 C  CA  . THR   A 1 409 ? -27.80507 -12.39771 -9.20454  1.000 31.22031 ? 409 THR   A CA  1 
ATOM   2612 C  C   . THR   A 1 409 ? -29.03439 -12.89676 -9.95390  1.000 33.30857 ? 409 THR   A C   1 
ATOM   2613 O  O   . THR   A 1 409 ? -30.07670 -12.23450 -9.91847  1.000 39.62890 ? 409 THR   A O   1 
ATOM   2614 C  CB  . THR   A 1 409 ? -27.59897 -10.90942 -9.49080  1.000 27.64572 ? 409 THR   A CB  1 
ATOM   2615 O  OG1 . THR   A 1 409 ? -27.53190 -10.70471 -10.90568 1.000 30.24326 ? 409 THR   A OG1 1 
ATOM   2616 C  CG2 . THR   A 1 409 ? -26.30618 -10.42451 -8.85985  1.000 24.15025 ? 409 THR   A CG2 1 
ATOM   2617 N  N   . ILE   A 1 410 ? -28.93805 -14.03793 -10.62900 1.000 27.19556 ? 410 ILE   A N   1 
ATOM   2618 C  CA  . ILE   A 1 410 ? -30.07100 -14.58700 -11.36248 1.000 34.52705 ? 410 ILE   A CA  1 
ATOM   2619 C  C   . ILE   A 1 410 ? -30.73670 -15.69979 -10.56146 1.000 25.62524 ? 410 ILE   A C   1 
ATOM   2620 O  O   . ILE   A 1 410 ? -30.06396 -16.58864 -10.03748 1.000 32.39410 ? 410 ILE   A O   1 
ATOM   2621 C  CB  . ILE   A 1 410 ? -29.64421 -15.10225 -12.74367 1.000 29.45996 ? 410 ILE   A CB  1 
ATOM   2622 C  CG1 . ILE   A 1 410 ? -28.94374 -13.99433 -13.53250 1.000 27.90243 ? 410 ILE   A CG1 1 
ATOM   2623 C  CG2 . ILE   A 1 410 ? -30.85267 -15.61812 -13.50585 1.000 25.40045 ? 410 ILE   A CG2 1 
ATOM   2624 C  CD1 . ILE   A 1 410 ? -28.47462 -14.42259 -14.90732 1.000 24.88670 ? 410 ILE   A CD1 1 
ATOM   2625 N  N   . GLU   B 1 87  ? -45.56191 16.34300  -86.57353 1.000 69.60612 ? 87  GLU   B N   1 
ATOM   2626 C  CA  . GLU   B 1 87  ? -45.89269 16.15109  -85.16675 1.000 77.44958 ? 87  GLU   B CA  1 
ATOM   2627 C  C   . GLU   B 1 87  ? -44.68942 15.65367  -84.37393 1.000 80.36673 ? 87  GLU   B C   1 
ATOM   2628 O  O   . GLU   B 1 87  ? -44.21427 14.53644  -84.58337 1.000 75.03286 ? 87  GLU   B O   1 
ATOM   2629 C  CB  . GLU   B 1 87  ? -47.05936 15.17041  -85.01587 1.000 76.30170 ? 87  GLU   B CB  1 
ATOM   2630 C  CG  . GLU   B 1 87  ? -47.40167 14.81686  -83.57175 1.000 69.78686 ? 87  GLU   B CG  1 
ATOM   2631 C  CD  . GLU   B 1 87  ? -48.08871 15.94527  -82.82698 1.000 70.30484 ? 87  GLU   B CD  1 
ATOM   2632 O  OE1 . GLU   B 1 87  ? -49.32012 15.86473  -82.63482 1.000 70.46673 ? 87  GLU   B OE1 1 
ATOM   2633 O  OE2 . GLU   B 1 87  ? -47.40072 16.90989  -82.43087 1.000 70.06853 ? 87  GLU   B OE2 1 
ATOM   2634 N  N   . GLN   B 1 88  ? -44.20106 16.51063  -83.47387 1.000 81.13530 ? 88  GLN   B N   1 
ATOM   2635 C  CA  . GLN   B 1 88  ? -43.14852 16.12920  -82.53791 1.000 77.34061 ? 88  GLN   B CA  1 
ATOM   2636 C  C   . GLN   B 1 88  ? -43.47327 14.80786  -81.85257 1.000 75.41513 ? 88  GLN   B C   1 
ATOM   2637 O  O   . GLN   B 1 88  ? -42.69053 13.85200  -81.89880 1.000 66.91166 ? 88  GLN   B O   1 
ATOM   2638 C  CB  . GLN   B 1 88  ? -42.96942 17.23660  -81.49588 1.000 73.37894 ? 88  GLN   B CB  1 
ATOM   2639 C  CG  . GLN   B 1 88  ? -41.75585 18.12669  -81.69138 1.000 70.57016 ? 88  GLN   B CG  1 
ATOM   2640 C  CD  . GLN   B 1 88  ? -40.48816 17.51928  -81.12297 1.000 71.18938 ? 88  GLN   B CD  1 
ATOM   2641 O  OE1 . GLN   B 1 88  ? -40.28895 16.30625  -81.17127 1.000 66.00487 ? 88  GLN   B OE1 1 
ATOM   2642 N  NE2 . GLN   B 1 88  ? -39.62972 18.36339  -80.56280 1.000 66.86338 ? 88  GLN   B NE2 1 
ATOM   2643 N  N   . GLU   B 1 89  ? -44.64731 14.74053  -81.22075 1.000 75.10846 ? 89  GLU   B N   1 
ATOM   2644 C  CA  . GLU   B 1 89  ? -45.00610 13.57574  -80.42007 1.000 72.25454 ? 89  GLU   B CA  1 
ATOM   2645 C  C   . GLU   B 1 89  ? -45.11859 12.31308  -81.26350 1.000 68.36336 ? 89  GLU   B C   1 
ATOM   2646 O  O   . GLU   B 1 89  ? -44.97926 11.20431  -80.73592 1.000 69.12408 ? 89  GLU   B O   1 
ATOM   2647 C  CB  . GLU   B 1 89  ? -46.31571 13.84723  -79.68164 1.000 71.39422 ? 89  GLU   B CB  1 
ATOM   2648 C  CG  . GLU   B 1 89  ? -46.23491 15.03420  -78.73999 1.000 72.83607 ? 89  GLU   B CG  1 
ATOM   2649 C  CD  . GLU   B 1 89  ? -47.52180 15.82942  -78.68628 1.000 75.82703 ? 89  GLU   B CD  1 
ATOM   2650 O  OE1 . GLU   B 1 89  ? -48.44808 15.52319  -79.46664 1.000 76.17595 ? 89  GLU   B OE1 1 
ATOM   2651 O  OE2 . GLU   B 1 89  ? -47.60354 16.76563  -77.86417 1.000 73.92033 ? 89  GLU   B OE2 1 
ATOM   2652 N  N   . ASP   B 1 90  ? -45.36712 12.45277  -82.56688 1.000 71.19887 ? 90  ASP   B N   1 
ATOM   2653 C  CA  . ASP   B 1 90  ? -45.42625 11.27918  -83.43190 1.000 65.83888 ? 90  ASP   B CA  1 
ATOM   2654 C  C   . ASP   B 1 90  ? -44.03749 10.69332  -83.64667 1.000 57.07558 ? 90  ASP   B C   1 
ATOM   2655 O  O   . ASP   B 1 90  ? -43.83567 9.48185   -83.50324 1.000 58.07952 ? 90  ASP   B O   1 
ATOM   2656 C  CB  . ASP   B 1 90  ? -46.07300 11.63921  -84.76942 1.000 71.53127 ? 90  ASP   B CB  1 
ATOM   2657 C  CG  . ASP   B 1 90  ? -46.49363 10.41414  -85.56259 1.000 72.11223 ? 90  ASP   B CG  1 
ATOM   2658 O  OD1 . ASP   B 1 90  ? -47.55235 9.84838   -85.23530 1.000 74.93620 ? 90  ASP   B OD1 1 
ATOM   2659 O  OD2 . ASP   B 1 90  ? -45.79150 10.02205  -86.51793 1.000 72.59146 ? 90  ASP   B OD2 1 
ATOM   2660 N  N   . VAL   B 1 91  ? -43.06304 11.54390  -83.98145 1.000 56.15150 ? 91  VAL   B N   1 
ATOM   2661 C  CA  . VAL   B 1 91  ? -41.69793 11.06763  -84.18792 1.000 53.00375 ? 91  VAL   B CA  1 
ATOM   2662 C  C   . VAL   B 1 91  ? -41.14523 10.46535  -82.90401 1.000 49.96943 ? 91  VAL   B C   1 
ATOM   2663 O  O   . VAL   B 1 91  ? -40.49842 9.41090   -82.92432 1.000 41.43746 ? 91  VAL   B O   1 
ATOM   2664 C  CB  . VAL   B 1 91  ? -40.80156 12.20703  -84.70632 1.000 52.13961 ? 91  VAL   B CB  1 
ATOM   2665 C  CG1 . VAL   B 1 91  ? -39.47775 11.64662  -85.20438 1.000 47.79539 ? 91  VAL   B CG1 1 
ATOM   2666 C  CG2 . VAL   B 1 91  ? -41.50557 12.98531  -85.80537 1.000 59.67597 ? 91  VAL   B CG2 1 
ATOM   2667 N  N   . LEU   B 1 92  ? -41.38838 11.12479  -81.76860 1.000 48.53730 ? 92  LEU   B N   1 
ATOM   2668 C  CA  . LEU   B 1 92  ? -40.97180 10.57086  -80.48454 1.000 44.35519 ? 92  LEU   B CA  1 
ATOM   2669 C  C   . LEU   B 1 92  ? -41.59284 9.19868   -80.25722 1.000 45.30564 ? 92  LEU   B C   1 
ATOM   2670 O  O   . LEU   B 1 92  ? -40.91247 8.25938   -79.82838 1.000 42.02541 ? 92  LEU   B O   1 
ATOM   2671 C  CB  . LEU   B 1 92  ? -41.35113 11.52657  -79.35288 1.000 47.43321 ? 92  LEU   B CB  1 
ATOM   2672 C  CG  . LEU   B 1 92  ? -41.08786 11.02701  -77.92952 1.000 44.56303 ? 92  LEU   B CG  1 
ATOM   2673 C  CD1 . LEU   B 1 92  ? -39.59443 10.92213  -77.64995 1.000 40.64069 ? 92  LEU   B CD1 1 
ATOM   2674 C  CD2 . LEU   B 1 92  ? -41.76979 11.92172  -76.90502 1.000 38.12222 ? 92  LEU   B CD2 1 
ATOM   2675 N  N   . ALA   B 1 93  ? -42.89089 9.06458   -80.54996 1.000 48.65606 ? 93  ALA   B N   1 
ATOM   2676 C  CA  . ALA   B 1 93  ? -43.56872 7.78417   -80.37271 1.000 46.74153 ? 93  ALA   B CA  1 
ATOM   2677 C  C   . ALA   B 1 93  ? -42.96518 6.70930   -81.25961 1.000 44.25205 ? 93  ALA   B C   1 
ATOM   2678 O  O   . ALA   B 1 93  ? -42.92883 5.53270   -80.87915 1.000 42.49340 ? 93  ALA   B O   1 
ATOM   2679 C  CB  . ALA   B 1 93  ? -45.06020 7.92910   -80.67498 1.000 50.03370 ? 93  ALA   B CB  1 
ATOM   2680 N  N   . LYS   B 1 94  ? -42.48954 7.09659   -82.44356 1.000 45.47328 ? 94  LYS   B N   1 
ATOM   2681 C  CA  . LYS   B 1 94  ? -41.89818 6.13186   -83.36200 1.000 44.89919 ? 94  LYS   B CA  1 
ATOM   2682 C  C   . LYS   B 1 94  ? -40.52456 5.67816   -82.88136 1.000 43.22749 ? 94  LYS   B C   1 
ATOM   2683 O  O   . LYS   B 1 94  ? -40.21880 4.48076   -82.90964 1.000 41.30514 ? 94  LYS   B O   1 
ATOM   2684 C  CB  . LYS   B 1 94  ? -41.82055 6.73234   -84.76864 1.000 47.09585 ? 94  LYS   B CB  1 
ATOM   2685 C  CG  . LYS   B 1 94  ? -40.98869 5.90831   -85.75873 1.000 54.10741 ? 94  LYS   B CG  1 
ATOM   2686 C  CD  . LYS   B 1 94  ? -41.61419 4.55284   -86.05363 1.000 55.10647 ? 94  LYS   B CD  1 
ATOM   2687 C  CE  . LYS   B 1 94  ? -40.64688 3.65425   -86.79464 1.000 55.58372 ? 94  LYS   B CE  1 
ATOM   2688 N  NZ  . LYS   B 1 94  ? -39.26016 3.94021   -86.39591 1.000 57.66319 ? 94  LYS   B NZ  1 
ATOM   2689 N  N   . GLU   B 1 95  ? -39.68606 6.61538   -82.42922 1.000 40.67310 ? 95  GLU   B N   1 
ATOM   2690 C  CA  . GLU   B 1 95  ? -38.36878 6.24428   -81.91833 1.000 41.48379 ? 95  GLU   B CA  1 
ATOM   2691 C  C   . GLU   B 1 95  ? -38.48622 5.32595   -80.70777 1.000 36.09425 ? 95  GLU   B C   1 
ATOM   2692 O  O   . GLU   B 1 95  ? -37.69453 4.38894   -80.54795 1.000 35.77176 ? 95  GLU   B O   1 
ATOM   2693 C  CB  . GLU   B 1 95  ? -37.57159 7.49963   -81.56017 1.000 39.18648 ? 95  GLU   B CB  1 
ATOM   2694 C  CG  . GLU   B 1 95  ? -37.33674 8.45936   -82.72109 1.000 42.43818 ? 95  GLU   B CG  1 
ATOM   2695 C  CD  . GLU   B 1 95  ? -36.24320 7.99602   -83.66595 1.000 46.66936 ? 95  GLU   B CD  1 
ATOM   2696 O  OE1 . GLU   B 1 95  ? -35.68117 6.90302   -83.44489 1.000 45.47560 ? 95  GLU   B OE1 1 
ATOM   2697 O  OE2 . GLU   B 1 95  ? -35.93866 8.73225   -84.62819 1.000 53.42843 ? 95  GLU   B OE2 1 
ATOM   2698 N  N   . LEU   B 1 96  ? -39.47730 5.57449   -79.84855 1.000 36.78144 ? 96  LEU   B N   1 
ATOM   2699 C  CA  . LEU   B 1 96  ? -39.67785 4.74248   -78.66905 1.000 37.30801 ? 96  LEU   B CA  1 
ATOM   2700 C  C   . LEU   B 1 96  ? -40.11591 3.32631   -79.02021 1.000 41.08386 ? 96  LEU   B C   1 
ATOM   2701 O  O   . LEU   B 1 96  ? -40.01655 2.43554   -78.17052 1.000 39.04823 ? 96  LEU   B O   1 
ATOM   2702 C  CB  . LEU   B 1 96  ? -40.69683 5.39895   -77.73821 1.000 33.86709 ? 96  LEU   B CB  1 
ATOM   2703 C  CG  . LEU   B 1 96  ? -40.17110 6.64997   -77.03271 1.000 37.41395 ? 96  LEU   B CG  1 
ATOM   2704 C  CD1 . LEU   B 1 96  ? -41.31165 7.49130   -76.48776 1.000 38.13630 ? 96  LEU   B CD1 1 
ATOM   2705 C  CD2 . LEU   B 1 96  ? -39.21336 6.25647   -75.92006 1.000 31.28792 ? 96  LEU   B CD2 1 
ATOM   2706 N  N   . GLU   B 1 97  ? -40.58971 3.09181   -80.24734 1.000 38.12190 ? 97  GLU   B N   1 
ATOM   2707 C  CA  . GLU   B 1 97  ? -40.87394 1.72739   -80.67826 1.000 40.55778 ? 97  GLU   B CA  1 
ATOM   2708 C  C   . GLU   B 1 97  ? -39.62737 0.85322   -80.69389 1.000 34.51731 ? 97  GLU   B C   1 
ATOM   2709 O  O   . GLU   B 1 97  ? -39.75270 -0.37434  -80.76484 1.000 36.63469 ? 97  GLU   B O   1 
ATOM   2710 C  CB  . GLU   B 1 97  ? -41.51697 1.72347   -82.06794 1.000 43.33270 ? 97  GLU   B CB  1 
ATOM   2711 C  CG  . GLU   B 1 97  ? -42.80849 2.51716   -82.16865 1.000 42.32036 ? 97  GLU   B CG  1 
ATOM   2712 C  CD  . GLU   B 1 97  ? -43.55573 2.24813   -83.46140 1.000 51.02938 ? 97  GLU   B CD  1 
ATOM   2713 O  OE1 . GLU   B 1 97  ? -43.87870 1.07106   -83.72699 1.000 55.46422 ? 97  GLU   B OE1 1 
ATOM   2714 O  OE2 . GLU   B 1 97  ? -43.82080 3.21117   -84.21099 1.000 48.20645 ? 97  GLU   B OE2 1 
ATOM   2715 N  N   . ASP   B 1 98  ? -38.43854 1.45084   -80.63396 1.000 36.87398 ? 98  ASP   B N   1 
ATOM   2716 C  CA  . ASP   B 1 98  ? -37.18142 0.72303   -80.54023 1.000 38.73536 ? 98  ASP   B CA  1 
ATOM   2717 C  C   . ASP   B 1 98  ? -36.72409 0.51944   -79.10011 1.000 35.41443 ? 98  ASP   B C   1 
ATOM   2718 O  O   . ASP   B 1 98  ? -35.57055 0.13450   -78.88148 1.000 30.51488 ? 98  ASP   B O   1 
ATOM   2719 C  CB  . ASP   B 1 98  ? -36.08895 1.45642   -81.32464 1.000 40.02874 ? 98  ASP   B CB  1 
ATOM   2720 C  CG  . ASP   B 1 98  ? -36.28598 1.36672   -82.82244 1.000 45.55231 ? 98  ASP   B CG  1 
ATOM   2721 O  OD1 . ASP   B 1 98  ? -37.32926 0.83195   -83.25157 1.000 43.69815 ? 98  ASP   B OD1 1 
ATOM   2722 O  OD2 . ASP   B 1 98  ? -35.40054 1.83554   -83.56969 1.000 51.69812 ? 98  ASP   B OD2 1 
ATOM   2723 N  N   . VAL   B 1 99  ? -37.60061 0.76195   -78.11922 1.000 35.13665 ? 99  VAL   B N   1 
ATOM   2724 C  CA  . VAL   B 1 99  ? -37.21586 0.71245   -76.71010 1.000 33.26962 ? 99  VAL   B CA  1 
ATOM   2725 C  C   . VAL   B 1 99  ? -36.65420 -0.64688  -76.31346 1.000 34.12512 ? 99  VAL   B C   1 
ATOM   2726 O  O   . VAL   B 1 99  ? -35.91102 -0.74554  -75.33090 1.000 35.98852 ? 99  VAL   B O   1 
ATOM   2727 C  CB  . VAL   B 1 99  ? -38.42008 1.09416   -75.81744 1.000 36.28943 ? 99  VAL   B CB  1 
ATOM   2728 C  CG1 . VAL   B 1 99  ? -39.42091 -0.05206  -75.73264 1.000 36.47848 ? 99  VAL   B CG1 1 
ATOM   2729 C  CG2 . VAL   B 1 99  ? -37.95590 1.51917   -74.43075 1.000 34.71344 ? 99  VAL   B CG2 1 
ATOM   2730 N  N   . ASN   B 1 100 ? -36.97585 -1.69965  -77.06225 1.000 34.60791 ? 100 ASN   B N   1 
ATOM   2731 C  CA  . ASN   B 1 100 ? -36.50489 -3.04437  -76.76369 1.000 30.82971 ? 100 ASN   B CA  1 
ATOM   2732 C  C   . ASN   B 1 100 ? -35.22376 -3.40736  -77.50325 1.000 33.73427 ? 100 ASN   B C   1 
ATOM   2733 O  O   . ASN   B 1 100 ? -34.80582 -4.56845  -77.45104 1.000 30.81362 ? 100 ASN   B O   1 
ATOM   2734 C  CB  . ASN   B 1 100 ? -37.58879 -4.07348  -77.10022 1.000 38.86166 ? 100 ASN   B CB  1 
ATOM   2735 C  CG  . ASN   B 1 100 ? -38.82539 -3.92446  -76.23962 1.000 44.72472 ? 100 ASN   B CG  1 
ATOM   2736 O  OD1 . ASN   B 1 100 ? -38.80444 -3.24386  -75.21483 1.000 36.12912 ? 100 ASN   B OD1 1 
ATOM   2737 N  ND2 . ASN   B 1 100 ? -39.91122 -4.57227  -76.64756 1.000 46.79716 ? 100 ASN   B ND2 1 
ATOM   2738 N  N   . LYS   B 1 101 ? -34.58926 -2.45609  -78.18372 1.000 32.72671 ? 101 LYS   B N   1 
ATOM   2739 C  CA  . LYS   B 1 101 ? -33.45777 -2.75628  -79.04898 1.000 33.96925 ? 101 LYS   B CA  1 
ATOM   2740 C  C   . LYS   B 1 101 ? -32.18091 -2.09000  -78.55594 1.000 28.29201 ? 101 LYS   B C   1 
ATOM   2741 O  O   . LYS   B 1 101 ? -32.17805 -0.90903  -78.19047 1.000 27.47113 ? 101 LYS   B O   1 
ATOM   2742 C  CB  . LYS   B 1 101 ? -33.73167 -2.32570  -80.49451 1.000 36.36184 ? 101 LYS   B CB  1 
ATOM   2743 C  CG  . LYS   B 1 101 ? -34.91528 -3.02555  -81.14163 1.000 35.88130 ? 101 LYS   B CG  1 
ATOM   2744 C  CD  . LYS   B 1 101 ? -34.84539 -2.91594  -82.65729 1.000 40.26606 ? 101 LYS   B CD  1 
ATOM   2745 C  CE  . LYS   B 1 101 ? -35.97575 -2.06849  -83.21464 1.000 46.29698 ? 101 LYS   B CE  1 
ATOM   2746 N  NZ  . LYS   B 1 101 ? -37.22953 -2.84606  -83.41868 1.000 39.61300 ? 101 LYS   B NZ  1 
ATOM   2747 N  N   . TRP   B 1 102 ? -31.10234 -2.87252  -78.54938 1.000 25.32797 ? 102 TRP   B N   1 
ATOM   2748 C  CA  . TRP   B 1 102 ? -29.76115 -2.33513  -78.37562 1.000 28.02858 ? 102 TRP   B CA  1 
ATOM   2749 C  C   . TRP   B 1 102 ? -29.47952 -1.30368  -79.45758 1.000 36.27613 ? 102 TRP   B C   1 
ATOM   2750 O  O   . TRP   B 1 102 ? -29.88268 -1.46455  -80.61301 1.000 39.45878 ? 102 TRP   B O   1 
ATOM   2751 C  CB  . TRP   B 1 102 ? -28.73444 -3.46658  -78.44895 1.000 26.44006 ? 102 TRP   B CB  1 
ATOM   2752 C  CG  . TRP   B 1 102 ? -27.49120 -3.25479  -77.63573 1.000 29.86541 ? 102 TRP   B CG  1 
ATOM   2753 C  CD1 . TRP   B 1 102 ? -26.22694 -3.04450  -78.10816 1.000 27.48500 ? 102 TRP   B CD1 1 
ATOM   2754 C  CD2 . TRP   B 1 102 ? -27.38874 -3.26253  -76.20704 1.000 26.47831 ? 102 TRP   B CD2 1 
ATOM   2755 N  NE1 . TRP   B 1 102 ? -25.34650 -2.90948  -77.06138 1.000 21.79267 ? 102 TRP   B NE1 1 
ATOM   2756 C  CE2 . TRP   B 1 102 ? -26.03472 -3.04011  -75.88367 1.000 24.64955 ? 102 TRP   B CE2 1 
ATOM   2757 C  CE3 . TRP   B 1 102 ? -28.31117 -3.43025  -75.16981 1.000 23.03307 ? 102 TRP   B CE3 1 
ATOM   2758 C  CZ2 . TRP   B 1 102 ? -25.58175 -2.98061  -74.56665 1.000 24.08882 ? 102 TRP   B CZ2 1 
ATOM   2759 C  CZ3 . TRP   B 1 102 ? -27.85952 -3.37083  -73.86342 1.000 22.60416 ? 102 TRP   B CZ3 1 
ATOM   2760 C  CH2 . TRP   B 1 102 ? -26.50752 -3.14831  -73.57333 1.000 22.55493 ? 102 TRP   B CH2 1 
ATOM   2761 N  N   . GLY   B 1 103 ? -28.77055 -0.24540  -79.08695 1.000 32.79583 ? 103 GLY   B N   1 
ATOM   2762 C  CA  . GLY   B 1 103 ? -28.63407 0.86027   -80.00216 1.000 27.72924 ? 103 GLY   B CA  1 
ATOM   2763 C  C   . GLY   B 1 103 ? -29.89470 1.66848   -80.14137 1.000 34.17555 ? 103 GLY   B C   1 
ATOM   2764 O  O   . GLY   B 1 103 ? -30.09686 2.30029   -81.18537 1.000 30.68724 ? 103 GLY   B O   1 
ATOM   2765 N  N   . LEU   B 1 104 ? -30.77395 1.63313   -79.13201 1.000 35.40042 ? 104 LEU   B N   1 
ATOM   2766 C  CA  . LEU   B 1 104 ? -31.88648 2.56528   -79.09769 1.000 29.71121 ? 104 LEU   B CA  1 
ATOM   2767 C  C   . LEU   B 1 104 ? -31.36178 3.95281   -79.37113 1.000 40.68885 ? 104 LEU   B C   1 
ATOM   2768 O  O   . LEU   B 1 104 ? -30.29162 4.34625   -78.90092 1.000 40.58848 ? 104 LEU   B O   1 
ATOM   2769 C  CB  . LEU   B 1 104 ? -32.63055 2.57248   -77.75722 1.000 32.82948 ? 104 LEU   B CB  1 
ATOM   2770 C  CG  . LEU   B 1 104 ? -33.67222 3.71474   -77.70065 1.000 30.07374 ? 104 LEU   B CG  1 
ATOM   2771 C  CD1 . LEU   B 1 104 ? -34.94390 3.38921   -78.48287 1.000 37.00041 ? 104 LEU   B CD1 1 
ATOM   2772 C  CD2 . LEU   B 1 104 ? -34.00643 4.18769   -76.28951 1.000 26.72067 ? 104 LEU   B CD2 1 
ATOM   2773 N  N   . HIS   B 1 105 ? -32.11157 4.66375   -80.17195 1.000 35.80510 ? 105 HIS   B N   1 
ATOM   2774 C  CA  . HIS   B 1 105 ? -31.76836 6.00658   -80.56560 1.000 39.91129 ? 105 HIS   B CA  1 
ATOM   2775 C  C   . HIS   B 1 105 ? -32.09442 6.92178   -79.37791 1.000 42.76378 ? 105 HIS   B C   1 
ATOM   2776 O  O   . HIS   B 1 105 ? -33.23873 7.31416   -79.17621 1.000 52.85161 ? 105 HIS   B O   1 
ATOM   2777 C  CB  . HIS   B 1 105 ? -32.54405 6.31050   -81.83881 1.000 50.83192 ? 105 HIS   B CB  1 
ATOM   2778 C  CG  . HIS   B 1 105 ? -31.93523 5.72282   -83.07113 1.000 50.48409 ? 105 HIS   B CG  1 
ATOM   2779 N  ND1 . HIS   B 1 105 ? -32.60467 5.65774   -84.27418 1.000 52.05270 ? 105 HIS   B ND1 1 
ATOM   2780 C  CD2 . HIS   B 1 105 ? -30.72280 5.15932   -83.28299 1.000 47.57621 ? 105 HIS   B CD2 1 
ATOM   2781 C  CE1 . HIS   B 1 105 ? -31.83068 5.07797   -85.17395 1.000 43.54984 ? 105 HIS   B CE1 1 
ATOM   2782 N  NE2 . HIS   B 1 105 ? -30.68355 4.76573   -84.59807 1.000 46.45851 ? 105 HIS   B NE2 1 
ATOM   2783 N  N   . VAL   B 1 106 ? -31.08733 7.27029   -78.56521 1.000 32.89121 ? 106 VAL   B N   1 
ATOM   2784 C  CA  . VAL   B 1 106 ? -31.37556 7.95539   -77.29748 1.000 29.38467 ? 106 VAL   B CA  1 
ATOM   2785 C  C   . VAL   B 1 106 ? -31.21937 9.48167   -77.36787 1.000 26.79053 ? 106 VAL   B C   1 
ATOM   2786 O  O   . VAL   B 1 106 ? -31.96122 10.20241  -76.69125 1.000 26.99051 ? 106 VAL   B O   1 
ATOM   2787 C  CB  . VAL   B 1 106 ? -30.52111 7.37464   -76.15046 1.000 29.63484 ? 106 VAL   B CB  1 
ATOM   2788 C  CG1 . VAL   B 1 106 ? -29.04783 7.57841   -76.42212 1.000 26.26787 ? 106 VAL   B CG1 1 
ATOM   2789 C  CG2 . VAL   B 1 106 ? -30.91026 8.00293   -74.80413 1.000 22.82750 ? 106 VAL   B CG2 1 
ATOM   2790 N  N   . PHE   B 1 107 ? -30.28131 10.00043  -78.17107 1.000 26.28484 ? 107 PHE   B N   1 
ATOM   2791 C  CA  . PHE   B 1 107 ? -30.06247 11.44922  -78.23601 1.000 30.04535 ? 107 PHE   B CA  1 
ATOM   2792 C  C   . PHE   B 1 107 ? -31.19393 12.16675  -78.97442 1.000 32.36012 ? 107 PHE   B C   1 
ATOM   2793 O  O   . PHE   B 1 107 ? -31.62549 13.24631  -78.56057 1.000 34.70405 ? 107 PHE   B O   1 
ATOM   2794 C  CB  . PHE   B 1 107 ? -28.71806 11.75351  -78.90163 1.000 28.61478 ? 107 PHE   B CB  1 
ATOM   2795 C  CG  . PHE   B 1 107 ? -27.52744 11.24680  -78.13326 1.000 32.98745 ? 107 PHE   B CG  1 
ATOM   2796 C  CD1 . PHE   B 1 107 ? -27.03899 11.94862  -77.04360 1.000 22.38529 ? 107 PHE   B CD1 1 
ATOM   2797 C  CD2 . PHE   B 1 107 ? -26.89375 10.07112  -78.50504 1.000 27.58469 ? 107 PHE   B CD2 1 
ATOM   2798 C  CE1 . PHE   B 1 107 ? -25.94372 11.48431  -76.33563 1.000 25.09789 ? 107 PHE   B CE1 1 
ATOM   2799 C  CE2 . PHE   B 1 107 ? -25.79846 9.60234   -77.80110 1.000 19.34362 ? 107 PHE   B CE2 1 
ATOM   2800 C  CZ  . PHE   B 1 107 ? -25.32304 10.31001  -76.71626 1.000 22.08520 ? 107 PHE   B CZ  1 
ATOM   2801 N  N   . ARG   B 1 108 ? -31.66494 11.60875  -80.08560 1.000 33.06513 ? 108 ARG   B N   1 
ATOM   2802 C  CA  . ARG   B 1 108 ? -32.86865 12.14131  -80.72084 1.000 38.01780 ? 108 ARG   B CA  1 
ATOM   2803 C  C   . ARG   B 1 108 ? -34.09898 11.98699  -79.82483 1.000 32.15603 ? 108 ARG   B C   1 
ATOM   2804 O  O   . ARG   B 1 108 ? -34.96451 12.86691  -79.82851 1.000 36.53148 ? 108 ARG   B O   1 
ATOM   2805 C  CB  . ARG   B 1 108 ? -33.11778 11.48198  -82.08110 1.000 46.16048 ? 108 ARG   B CB  1 
ATOM   2806 C  CG  . ARG   B 1 108 ? -33.46282 10.02069  -81.98986 1.000 43.37674 ? 108 ARG   B CG  1 
ATOM   2807 C  CD  . ARG   B 1 108 ? -32.30120 9.26654   -81.42692 1.000 54.62604 ? 108 ARG   B CD  1 
ATOM   2808 N  NE  . ARG   B 1 108 ? -31.18683 8.98878   -82.32901 1.000 60.76571 ? 108 ARG   B NE  1 
ATOM   2809 C  CZ  . ARG   B 1 108 ? -29.89297 8.98058   -81.99314 1.000 64.68408 ? 108 ARG   B CZ  1 
ATOM   2810 N  NH1 . ARG   B 1 108 ? -29.49587 9.26821   -80.75581 1.000 67.45408 ? 108 ARG   B NH1 1 
ATOM   2811 N  NH2 . ARG   B 1 108 ? -28.99066 8.72303   -82.92167 1.000 66.67408 ? 108 ARG   B NH2 1 
ATOM   2812 N  N   . ILE   B 1 109 ? -34.21363 10.89747  -79.05168 1.000 32.56266 ? 109 ILE   B N   1 
ATOM   2813 C  CA  . ILE   B 1 109 ? -35.32433 10.81895  -78.09813 1.000 31.55762 ? 109 ILE   B CA  1 
ATOM   2814 C  C   . ILE   B 1 109 ? -35.19802 11.93505  -77.07114 1.000 30.15968 ? 109 ILE   B C   1 
ATOM   2815 O  O   . ILE   B 1 109 ? -36.19169 12.56175  -76.68352 1.000 33.08199 ? 109 ILE   B O   1 
ATOM   2816 C  CB  . ILE   B 1 109 ? -35.40178 9.42982   -77.42670 1.000 34.59924 ? 109 ILE   B CB  1 
ATOM   2817 C  CG1 . ILE   B 1 109 ? -36.03173 8.40764   -78.37359 1.000 31.19287 ? 109 ILE   B CG1 1 
ATOM   2818 C  CG2 . ILE   B 1 109 ? -36.19818 9.49150   -76.10679 1.000 25.93692 ? 109 ILE   B CG2 1 
ATOM   2819 C  CD1 . ILE   B 1 109 ? -35.91566 6.97454   -77.88980 1.000 32.80323 ? 109 ILE   B CD1 1 
ATOM   2820 N  N   . ALA   B 1 110 ? -33.96595 12.21918  -76.64030 1.000 32.25958 ? 110 ALA   B N   1 
ATOM   2821 C  CA  . ALA   B 1 110 ? -33.71301 13.37840  -75.79187 1.000 26.86883 ? 110 ALA   B CA  1 
ATOM   2822 C  C   . ALA   B 1 110 ? -34.17301 14.66290  -76.47176 1.000 32.97911 ? 110 ALA   B C   1 
ATOM   2823 O  O   . ALA   B 1 110 ? -34.89756 15.46923  -75.87731 1.000 34.80985 ? 110 ALA   B O   1 
ATOM   2824 C  CB  . ALA   B 1 110 ? -32.22510 13.44811  -75.44276 1.000 26.97673 ? 110 ALA   B CB  1 
ATOM   2825 N  N   . GLU   B 1 111 ? -33.77433 14.85917  -77.73106 1.000 35.40705 ? 111 GLU   B N   1 
ATOM   2826 C  CA  . GLU   B 1 111 ? -34.16731 16.06060  -78.46169 1.000 36.62758 ? 111 GLU   B CA  1 
ATOM   2827 C  C   . GLU   B 1 111 ? -35.68148 16.13717  -78.62903 1.000 37.52016 ? 111 GLU   B C   1 
ATOM   2828 O  O   . GLU   B 1 111 ? -36.29709 17.17293  -78.35076 1.000 34.95137 ? 111 GLU   B O   1 
ATOM   2829 C  CB  . GLU   B 1 111 ? -33.47389 16.09073  -79.82489 1.000 43.45416 ? 111 GLU   B CB  1 
ATOM   2830 C  CG  . GLU   B 1 111 ? -31.96823 16.29575  -79.76192 1.000 43.36461 ? 111 GLU   B CG  1 
ATOM   2831 C  CD  . GLU   B 1 111 ? -31.28431 15.98036  -81.07878 1.000 49.03824 ? 111 GLU   B CD  1 
ATOM   2832 O  OE1 . GLU   B 1 111 ? -30.08679 16.30535  -81.22314 1.000 51.26108 ? 111 GLU   B OE1 1 
ATOM   2833 O  OE2 . GLU   B 1 111 ? -31.94418 15.40254  -81.96833 1.000 48.59369 ? 111 GLU   B OE2 1 
ATOM   2834 N  N   . LEU   B 1 112 ? -36.30171 15.04097  -79.07488 1.000 29.59062 ? 112 LEU   B N   1 
ATOM   2835 C  CA  . LEU   B 1 112 ? -37.72557 15.05860  -79.39539 1.000 37.65095 ? 112 LEU   B CA  1 
ATOM   2836 C  C   . LEU   B 1 112 ? -38.61286 15.16939  -78.16053 1.000 40.15599 ? 112 LEU   B C   1 
ATOM   2837 O  O   . LEU   B 1 112 ? -39.75158 15.63531  -78.27564 1.000 39.91653 ? 112 LEU   B O   1 
ATOM   2838 C  CB  . LEU   B 1 112 ? -38.09825 13.80468  -80.19029 1.000 37.46063 ? 112 LEU   B CB  1 
ATOM   2839 C  CG  . LEU   B 1 112 ? -37.42567 13.63621  -81.55596 1.000 33.51381 ? 112 LEU   B CG  1 
ATOM   2840 C  CD1 . LEU   B 1 112 ? -37.52568 12.19439  -82.02881 1.000 33.21005 ? 112 LEU   B CD1 1 
ATOM   2841 C  CD2 . LEU   B 1 112 ? -38.02151 14.58238  -82.58641 1.000 34.22849 ? 112 LEU   B CD2 1 
ATOM   2842 N  N   . SER   B 1 113 ? -38.12867 14.75750  -76.99087 1.000 33.27740 ? 113 SER   B N   1 
ATOM   2843 C  CA  . SER   B 1 113 ? -38.92407 14.79813  -75.77009 1.000 31.57298 ? 113 SER   B CA  1 
ATOM   2844 C  C   . SER   B 1 113 ? -38.77299 16.10360  -74.99961 1.000 35.71331 ? 113 SER   B C   1 
ATOM   2845 O  O   . SER   B 1 113 ? -39.35732 16.23720  -73.91909 1.000 33.99988 ? 113 SER   B O   1 
ATOM   2846 C  CB  . SER   B 1 113 ? -38.55395 13.62418  -74.85685 1.000 33.47851 ? 113 SER   B CB  1 
ATOM   2847 O  OG  . SER   B 1 113 ? -37.27717 13.81655  -74.27383 1.000 26.85688 ? 113 SER   B OG  1 
ATOM   2848 N  N   . GLY   B 1 114 ? -38.01704 17.06329  -75.52293 1.000 32.79467 ? 114 GLY   B N   1 
ATOM   2849 C  CA  . GLY   B 1 114 ? -37.77043 18.29735  -74.80099 1.000 32.73978 ? 114 GLY   B CA  1 
ATOM   2850 C  C   . GLY   B 1 114 ? -36.76891 18.15277  -73.67764 1.000 36.70201 ? 114 GLY   B C   1 
ATOM   2851 O  O   . GLY   B 1 114 ? -36.96180 18.73333  -72.60121 1.000 38.52540 ? 114 GLY   B O   1 
ATOM   2852 N  N   . ASN   B 1 115 ? -35.69444 17.39453  -73.90561 1.000 33.61276 ? 115 ASN   B N   1 
ATOM   2853 C  CA  . ASN   B 1 115 ? -34.72240 17.04374  -72.86907 1.000 35.67546 ? 115 ASN   B CA  1 
ATOM   2854 C  C   . ASN   B 1 115 ? -35.39665 16.31273  -71.70961 1.000 31.75197 ? 115 ASN   B C   1 
ATOM   2855 O  O   . ASN   B 1 115 ? -35.13742 16.58835  -70.53619 1.000 28.03399 ? 115 ASN   B O   1 
ATOM   2856 C  CB  . ASN   B 1 115 ? -33.95204 18.27105  -72.37251 1.000 34.75607 ? 115 ASN   B CB  1 
ATOM   2857 C  CG  . ASN   B 1 115 ? -32.68206 17.89847  -71.62842 1.000 36.40591 ? 115 ASN   B CG  1 
ATOM   2858 O  OD1 . ASN   B 1 115 ? -32.14226 16.80606  -71.80826 1.000 28.37934 ? 115 ASN   B OD1 1 
ATOM   2859 N  ND2 . ASN   B 1 115 ? -32.20653 18.80068  -70.77775 1.000 34.40253 ? 115 ASN   B ND2 1 
ATOM   2860 N  N   . ARG   B 1 116 ? -36.26949 15.35805  -72.04422 1.000 33.16003 ? 116 ARG   B N   1 
ATOM   2861 C  CA  . ARG   B 1 116 ? -36.87117 14.46886  -71.04801 1.000 30.90135 ? 116 ARG   B CA  1 
ATOM   2862 C  C   . ARG   B 1 116 ? -36.72049 12.99568  -71.43405 1.000 26.93026 ? 116 ARG   B C   1 
ATOM   2863 O  O   . ARG   B 1 116 ? -37.67760 12.22567  -71.35470 1.000 27.02429 ? 116 ARG   B O   1 
ATOM   2864 C  CB  . ARG   B 1 116 ? -38.34212 14.82294  -70.85694 1.000 29.85731 ? 116 ARG   B CB  1 
ATOM   2865 C  CG  . ARG   B 1 116 ? -38.57938 16.18828  -70.24328 1.000 33.44328 ? 116 ARG   B CG  1 
ATOM   2866 C  CD  . ARG   B 1 116 ? -37.98468 16.26195  -68.84795 1.000 33.81423 ? 116 ARG   B CD  1 
ATOM   2867 N  NE  . ARG   B 1 116 ? -38.36243 17.48482  -68.14691 1.000 34.18784 ? 116 ARG   B NE  1 
ATOM   2868 C  CZ  . ARG   B 1 116 ? -38.11706 17.70826  -66.86024 1.000 32.46866 ? 116 ARG   B CZ  1 
ATOM   2869 N  NH1 . ARG   B 1 116 ? -37.49783 16.78702  -66.13478 1.000 27.35138 ? 116 ARG   B NH1 1 
ATOM   2870 N  NH2 . ARG   B 1 116 ? -38.49199 18.84858  -66.29714 1.000 30.25184 ? 116 ARG   B NH2 1 
ATOM   2871 N  N   . PRO   B 1 117 ? -35.51993 12.55904  -71.84610 1.000 27.20821 ? 117 PRO   B N   1 
ATOM   2872 C  CA  . PRO   B 1 117 ? -35.37819 11.14640  -72.22874 1.000 22.37732 ? 117 PRO   B CA  1 
ATOM   2873 C  C   . PRO   B 1 117 ? -35.52379 10.19543  -71.05587 1.000 24.26451 ? 117 PRO   B C   1 
ATOM   2874 O  O   . PRO   B 1 117 ? -36.05400 9.09337   -71.23527 1.000 20.64899 ? 117 PRO   B O   1 
ATOM   2875 C  CB  . PRO   B 1 117 ? -33.97155 11.08713  -72.83627 1.000 21.01236 ? 117 PRO   B CB  1 
ATOM   2876 C  CG  . PRO   B 1 117 ? -33.23348 12.13999  -72.11920 1.000 24.43469 ? 117 PRO   B CG  1 
ATOM   2877 C  CD  . PRO   B 1 117 ? -34.21881 13.25283  -71.90961 1.000 27.42324 ? 117 PRO   B CD  1 
ATOM   2878 N  N   . LEU   B 1 118 ? -35.08281 10.58693  -69.85801 1.000 24.98733 ? 118 LEU   B N   1 
ATOM   2879 C  CA  . LEU   B 1 118 ? -35.22238 9.70711   -68.70223 1.000 22.41934 ? 118 LEU   B CA  1 
ATOM   2880 C  C   . LEU   B 1 118 ? -36.68976 9.47951   -68.36118 1.000 20.35606 ? 118 LEU   B C   1 
ATOM   2881 O  O   . LEU   B 1 118 ? -37.10725 8.34415   -68.10941 1.000 25.43812 ? 118 LEU   B O   1 
ATOM   2882 C  CB  . LEU   B 1 118 ? -34.47136 10.28233  -67.50086 1.000 18.49601 ? 118 LEU   B CB  1 
ATOM   2883 C  CG  . LEU   B 1 118 ? -34.49486 9.41317   -66.24217 1.000 20.40351 ? 118 LEU   B CG  1 
ATOM   2884 C  CD1 . LEU   B 1 118 ? -33.94212 8.03091   -66.54906 1.000 16.69600 ? 118 LEU   B CD1 1 
ATOM   2885 C  CD2 . LEU   B 1 118 ? -33.70601 10.06871  -65.12160 1.000 13.59658 ? 118 LEU   B CD2 1 
ATOM   2886 N  N   . THR   B 1 119 ? -37.49231 10.54670  -68.35698 1.000 25.99707 ? 119 THR   B N   1 
ATOM   2887 C  CA  . THR   B 1 119 ? -38.90941 10.39753  -68.03828 1.000 25.24917 ? 119 THR   B CA  1 
ATOM   2888 C  C   . THR   B 1 119 ? -39.62488 9.55451   -69.08759 1.000 25.38742 ? 119 THR   B C   1 
ATOM   2889 O  O   . THR   B 1 119 ? -40.35762 8.61770   -68.75068 1.000 29.32924 ? 119 THR   B O   1 
ATOM   2890 C  CB  . THR   B 1 119 ? -39.57922 11.76653  -67.91085 1.000 28.51052 ? 119 THR   B CB  1 
ATOM   2891 O  OG1 . THR   B 1 119 ? -38.99002 12.49734  -66.82716 1.000 23.57801 ? 119 THR   B OG1 1 
ATOM   2892 C  CG2 . THR   B 1 119 ? -41.07589 11.60314  -67.65463 1.000 25.35854 ? 119 THR   B CG2 1 
ATOM   2893 N  N   . VAL   B 1 120 ? -39.41584 9.86298   -70.37085 1.000 25.30149 ? 120 VAL   B N   1 
ATOM   2894 C  CA  . VAL   B 1 120 ? -40.18165 9.17702   -71.40818 1.000 24.53482 ? 120 VAL   B CA  1 
ATOM   2895 C  C   . VAL   B 1 120 ? -39.71362 7.73545   -71.58159 1.000 23.06686 ? 120 VAL   B C   1 
ATOM   2896 O  O   . VAL   B 1 120 ? -40.52680 6.84828   -71.86547 1.000 29.65275 ? 120 VAL   B O   1 
ATOM   2897 C  CB  . VAL   B 1 120 ? -40.12809 9.95357   -72.74076 1.000 24.06668 ? 120 VAL   B CB  1 
ATOM   2898 C  CG1 . VAL   B 1 120 ? -40.61563 11.38613  -72.54924 1.000 23.01250 ? 120 VAL   B CG1 1 
ATOM   2899 C  CG2 . VAL   B 1 120 ? -38.72893 9.92464   -73.34374 1.000 25.61613 ? 120 VAL   B CG2 1 
ATOM   2900 N  N   . ILE   B 1 121 ? -38.41794 7.46439   -71.41104 1.000 22.59634 ? 121 ILE   B N   1 
ATOM   2901 C  CA  . ILE   B 1 121 ? -37.93764 6.09767   -71.59315 1.000 22.62810 ? 121 ILE   B CA  1 
ATOM   2902 C  C   . ILE   B 1 121 ? -38.31651 5.23200   -70.39875 1.000 29.09721 ? 121 ILE   B C   1 
ATOM   2903 O  O   . ILE   B 1 121 ? -38.68571 4.06325   -70.55915 1.000 26.93676 ? 121 ILE   B O   1 
ATOM   2904 C  CB  . ILE   B 1 121 ? -36.41966 6.09009   -71.85626 1.000 24.84109 ? 121 ILE   B CB  1 
ATOM   2905 C  CG1 . ILE   B 1 121 ? -36.13492 6.58740   -73.27496 1.000 27.68062 ? 121 ILE   B CG1 1 
ATOM   2906 C  CG2 . ILE   B 1 121 ? -35.82821 4.70033   -71.65380 1.000 20.12757 ? 121 ILE   B CG2 1 
ATOM   2907 C  CD1 . ILE   B 1 121 ? -34.66684 6.75241   -73.58349 1.000 18.88687 ? 121 ILE   B CD1 1 
ATOM   2908 N  N   . MET   B 1 122 ? -38.24901 5.78915   -69.18773 1.000 25.56257 ? 122 MET   B N   1 
ATOM   2909 C  CA  . MET   B 1 122 ? -38.70362 5.05396   -68.01134 1.000 25.46776 ? 122 MET   B CA  1 
ATOM   2910 C  C   . MET   B 1 122 ? -40.20522 4.80098   -68.07237 1.000 30.40859 ? 122 MET   B C   1 
ATOM   2911 O  O   . MET   B 1 122 ? -40.67008 3.68851   -67.79972 1.000 27.40831 ? 122 MET   B O   1 
ATOM   2912 C  CB  . MET   B 1 122 ? -38.33774 5.81820   -66.73984 1.000 20.11183 ? 122 MET   B CB  1 
ATOM   2913 C  CG  . MET   B 1 122 ? -36.89749 5.65446   -66.29486 1.000 23.88924 ? 122 MET   B CG  1 
ATOM   2914 S  SD  . MET   B 1 122 ? -36.64444 4.11994   -65.38593 1.000 22.41487 ? 122 MET   B SD  1 
ATOM   2915 C  CE  . MET   B 1 122 ? -37.42120 4.51470   -63.82149 1.000 18.84744 ? 122 MET   B CE  1 
ATOM   2916 N  N   . HIS   B 1 123 ? -40.98136 5.83088   -68.42400 1.000 27.13056 ? 123 HIS   B N   1 
ATOM   2917 C  CA  . HIS   B 1 123 ? -42.42409 5.66241   -68.57614 1.000 30.62592 ? 123 HIS   B CA  1 
ATOM   2918 C  C   . HIS   B 1 123 ? -42.74389 4.57181   -69.58973 1.000 31.01856 ? 123 HIS   B C   1 
ATOM   2919 O  O   . HIS   B 1 123 ? -43.61901 3.73019   -69.35472 1.000 33.48780 ? 123 HIS   B O   1 
ATOM   2920 C  CB  . HIS   B 1 123 ? -43.05891 6.98924   -68.99556 1.000 32.27873 ? 123 HIS   B CB  1 
ATOM   2921 C  CG  . HIS   B 1 123 ? -44.55661 6.98807   -68.97013 1.000 45.24652 ? 123 HIS   B CG  1 
ATOM   2922 N  ND1 . HIS   B 1 123 ? -45.30548 8.04292   -69.44641 1.000 49.92170 ? 123 HIS   B ND1 1 
ATOM   2923 C  CD2 . HIS   B 1 123 ? -45.44459 6.07041   -68.51901 1.000 38.30439 ? 123 HIS   B CD2 1 
ATOM   2924 C  CE1 . HIS   B 1 123 ? -46.58962 7.77386   -69.29375 1.000 45.45493 ? 123 HIS   B CE1 1 
ATOM   2925 N  NE2 . HIS   B 1 123 ? -46.70145 6.58264   -68.73397 1.000 42.05756 ? 123 HIS   B NE2 1 
ATOM   2926 N  N   . THR   B 1 124 ? -42.03121 4.56282   -70.71735 1.000 31.49646 ? 124 THR   B N   1 
ATOM   2927 C  CA  . THR   B 1 124 ? -42.26163 3.54718   -71.73897 1.000 30.23893 ? 124 THR   B CA  1 
ATOM   2928 C  C   . THR   B 1 124 ? -41.92468 2.15501   -71.21794 1.000 32.32788 ? 124 THR   B C   1 
ATOM   2929 O  O   . THR   B 1 124 ? -42.70618 1.21128   -71.38345 1.000 35.44471 ? 124 THR   B O   1 
ATOM   2930 C  CB  . THR   B 1 124 ? -41.43780 3.86940   -72.98609 1.000 26.49617 ? 124 THR   B CB  1 
ATOM   2931 O  OG1 . THR   B 1 124 ? -41.85007 5.13465   -73.51881 1.000 31.39665 ? 124 THR   B OG1 1 
ATOM   2932 C  CG2 . THR   B 1 124 ? -41.62214 2.79156   -74.04134 1.000 23.60772 ? 124 THR   B CG2 1 
ATOM   2933 N  N   . ILE   B 1 125 ? -40.76139 2.01125   -70.57835 1.000 28.12799 ? 125 ILE   B N   1 
ATOM   2934 C  CA  . ILE   B 1 125 ? -40.32807 0.70336   -70.09188 1.000 29.09530 ? 125 ILE   B CA  1 
ATOM   2935 C  C   . ILE   B 1 125 ? -41.27167 0.19393   -69.00900 1.000 31.52382 ? 125 ILE   B C   1 
ATOM   2936 O  O   . ILE   B 1 125 ? -41.56634 -1.00588  -68.93439 1.000 33.47905 ? 125 ILE   B O   1 
ATOM   2937 C  CB  . ILE   B 1 125 ? -38.87014 0.78197   -69.59962 1.000 29.00143 ? 125 ILE   B CB  1 
ATOM   2938 C  CG1 . ILE   B 1 125 ? -37.92559 0.95409   -70.79054 1.000 24.81202 ? 125 ILE   B CG1 1 
ATOM   2939 C  CG2 . ILE   B 1 125 ? -38.49375 -0.44930  -68.78909 1.000 22.53676 ? 125 ILE   B CG2 1 
ATOM   2940 C  CD1 . ILE   B 1 125 ? -36.51298 1.29525   -70.40558 1.000 25.11384 ? 125 ILE   B CD1 1 
ATOM   2941 N  N   . PHE   B 1 126 ? -41.77232 1.09647   -68.16262 1.000 28.35193 ? 126 PHE   B N   1 
ATOM   2942 C  CA  . PHE   B 1 126 ? -42.74347 0.69629   -67.14913 1.000 35.52955 ? 126 PHE   B CA  1 
ATOM   2943 C  C   . PHE   B 1 126 ? -44.04854 0.23047   -67.78503 1.000 38.76017 ? 126 PHE   B C   1 
ATOM   2944 O  O   . PHE   B 1 126 ? -44.60624 -0.79764  -67.38358 1.000 36.25546 ? 126 PHE   B O   1 
ATOM   2945 C  CB  . PHE   B 1 126 ? -42.99322 1.84895   -66.17727 1.000 33.27300 ? 126 PHE   B CB  1 
ATOM   2946 C  CG  . PHE   B 1 126 ? -42.03086 1.88788   -65.02452 1.000 33.56745 ? 126 PHE   B CG  1 
ATOM   2947 C  CD1 . PHE   B 1 126 ? -40.66660 1.97516   -65.24542 1.000 30.92372 ? 126 PHE   B CD1 1 
ATOM   2948 C  CD2 . PHE   B 1 126 ? -42.49180 1.84228   -63.71929 1.000 30.20193 ? 126 PHE   B CD2 1 
ATOM   2949 C  CE1 . PHE   B 1 126 ? -39.77997 2.01044   -64.18869 1.000 25.96257 ? 126 PHE   B CE1 1 
ATOM   2950 C  CE2 . PHE   B 1 126 ? -41.60951 1.87913   -62.65659 1.000 29.48755 ? 126 PHE   B CE2 1 
ATOM   2951 C  CZ  . PHE   B 1 126 ? -40.25122 1.96399   -62.89190 1.000 21.23327 ? 126 PHE   B CZ  1 
ATOM   2952 N  N   . GLN   B 1 127 ? -44.55272 0.97130   -68.77636 1.000 37.11678 ? 127 GLN   B N   1 
ATOM   2953 C  CA  . GLN   B 1 127 ? -45.73854 0.52029   -69.49917 1.000 39.41784 ? 127 GLN   B CA  1 
ATOM   2954 C  C   . GLN   B 1 127 ? -45.45947 -0.77465  -70.25157 1.000 41.71535 ? 127 GLN   B C   1 
ATOM   2955 O  O   . GLN   B 1 127 ? -46.28826 -1.69269  -70.25376 1.000 44.78771 ? 127 GLN   B O   1 
ATOM   2956 C  CB  . GLN   B 1 127 ? -46.21614 1.60632   -70.46564 1.000 35.59218 ? 127 GLN   B CB  1 
ATOM   2957 C  CG  . GLN   B 1 127 ? -46.76325 2.86699   -69.80333 1.000 43.24777 ? 127 GLN   B CG  1 
ATOM   2958 C  CD  . GLN   B 1 127 ? -48.12613 2.66345   -69.16386 1.000 40.56259 ? 127 GLN   B CD  1 
ATOM   2959 O  OE1 . GLN   B 1 127 ? -48.69134 1.57074   -69.20671 1.000 43.75466 ? 127 GLN   B OE1 1 
ATOM   2960 N  NE2 . GLN   B 1 127 ? -48.66381 3.72384   -68.57122 1.000 36.17971 ? 127 GLN   B NE2 1 
ATOM   2961 N  N   . GLU   B 1 128 ? -44.29080 -0.86551  -70.89329 1.000 37.26953 ? 128 GLU   B N   1 
ATOM   2962 C  CA  . GLU   B 1 128 ? -43.92157 -2.07563  -71.62146 1.000 36.08730 ? 128 GLU   B CA  1 
ATOM   2963 C  C   . GLU   B 1 128 ? -43.86018 -3.28966  -70.70385 1.000 42.12416 ? 128 GLU   B C   1 
ATOM   2964 O  O   . GLU   B 1 128 ? -44.15722 -4.40996  -71.13510 1.000 45.49428 ? 128 GLU   B O   1 
ATOM   2965 C  CB  . GLU   B 1 128 ? -42.57601 -1.86570  -72.32159 1.000 33.76051 ? 128 GLU   B CB  1 
ATOM   2966 C  CG  . GLU   B 1 128 ? -41.99674 -3.09876  -73.00680 1.000 34.86435 ? 128 GLU   B CG  1 
ATOM   2967 C  CD  . GLU   B 1 128 ? -42.66551 -3.41282  -74.33088 1.000 45.67146 ? 128 GLU   B CD  1 
ATOM   2968 O  OE1 . GLU   B 1 128 ? -42.43443 -4.51829  -74.86590 1.000 37.73131 ? 128 GLU   B OE1 1 
ATOM   2969 O  OE2 . GLU   B 1 128 ? -43.41645 -2.55425  -74.83933 1.000 40.33123 ? 128 GLU   B OE2 1 
ATOM   2970 N  N   . ARG   B 1 129 ? -43.49383 -3.09039  -69.43976 1.000 41.45614 ? 129 ARG   B N   1 
ATOM   2971 C  CA  . ARG   B 1 129 ? -43.34374 -4.18385  -68.49087 1.000 40.81616 ? 129 ARG   B CA  1 
ATOM   2972 C  C   . ARG   B 1 129 ? -44.53211 -4.34469  -67.55397 1.000 36.94845 ? 129 ARG   B C   1 
ATOM   2973 O  O   . ARG   B 1 129 ? -44.47958 -5.19785  -66.66228 1.000 37.77945 ? 129 ARG   B O   1 
ATOM   2974 C  CB  . ARG   B 1 129 ? -42.07060 -3.99285  -67.66536 1.000 37.00427 ? 129 ARG   B CB  1 
ATOM   2975 C  CG  . ARG   B 1 129 ? -40.81073 -4.31146  -68.43059 1.000 38.18508 ? 129 ARG   B CG  1 
ATOM   2976 C  CD  . ARG   B 1 129 ? -39.59806 -4.28616  -67.52840 1.000 38.20882 ? 129 ARG   B CD  1 
ATOM   2977 N  NE  . ARG   B 1 129 ? -38.39136 -4.66274  -68.25472 1.000 26.60134 ? 129 ARG   B NE  1 
ATOM   2978 C  CZ  . ARG   B 1 129 ? -38.01180 -5.91730  -68.47161 1.000 28.74235 ? 129 ARG   B CZ  1 
ATOM   2979 N  NH1 . ARG   B 1 129 ? -38.74468 -6.92457  -68.01514 1.000 34.71718 ? 129 ARG   B NH1 1 
ATOM   2980 N  NH2 . ARG   B 1 129 ? -36.89812 -6.16474  -69.14645 1.000 25.15667 ? 129 ARG   B NH2 1 
ATOM   2981 N  N   . ASP   B 1 130 ? -45.59021 -3.54871  -67.72327 1.000 39.40656 ? 130 ASP   B N   1 
ATOM   2982 C  CA  . ASP   B 1 130 ? -46.80829 -3.63852  -66.92136 1.000 46.52225 ? 130 ASP   B CA  1 
ATOM   2983 C  C   . ASP   B 1 130 ? -46.56727 -3.30135  -65.45225 1.000 40.97389 ? 130 ASP   B C   1 
ATOM   2984 O  O   . ASP   B 1 130 ? -47.36444 -3.68344  -64.58886 1.000 38.47151 ? 130 ASP   B O   1 
ATOM   2985 C  CB  . ASP   B 1 130 ? -47.44201 -5.03257  -67.04585 1.000 42.95283 ? 130 ASP   B CB  1 
ATOM   2986 C  CG  . ASP   B 1 130 ? -48.95207 -4.98898  -67.12746 1.000 48.07647 ? 130 ASP   B CG  1 
ATOM   2987 O  OD1 . ASP   B 1 130 ? -49.50838 -3.88374  -67.28104 1.000 42.63150 ? 130 ASP   B OD1 1 
ATOM   2988 O  OD2 . ASP   B 1 130 ? -49.58130 -6.06660  -67.05291 1.000 58.74205 ? 130 ASP   B OD2 1 
ATOM   2989 N  N   . LEU   B 1 131 ? -45.48574 -2.57486  -65.15077 1.000 36.53086 ? 131 LEU   B N   1 
ATOM   2990 C  CA  . LEU   B 1 131 ? -45.07438 -2.35790  -63.76685 1.000 34.32786 ? 131 LEU   B CA  1 
ATOM   2991 C  C   . LEU   B 1 131 ? -45.99138 -1.40391  -63.01185 1.000 34.90223 ? 131 LEU   B C   1 
ATOM   2992 O  O   . LEU   B 1 131 ? -46.04806 -1.47230  -61.77894 1.000 36.67853 ? 131 LEU   B O   1 
ATOM   2993 C  CB  . LEU   B 1 131 ? -43.63796 -1.83436  -63.72168 1.000 32.49901 ? 131 LEU   B CB  1 
ATOM   2994 C  CG  . LEU   B 1 131 ? -42.56106 -2.75269  -64.30085 1.000 34.00855 ? 131 LEU   B CG  1 
ATOM   2995 C  CD1 . LEU   B 1 131 ? -41.22273 -2.03377  -64.34998 1.000 33.74010 ? 131 LEU   B CD1 1 
ATOM   2996 C  CD2 . LEU   B 1 131 ? -42.45318 -4.04260  -63.49867 1.000 36.17296 ? 131 LEU   B CD2 1 
ATOM   2997 N  N   . LEU   B 1 132 ? -46.69679 -0.51102  -63.71032 1.000 32.66015 ? 132 LEU   B N   1 
ATOM   2998 C  CA  . LEU   B 1 132 ? -47.64849 0.35908   -63.02676 1.000 38.41705 ? 132 LEU   B CA  1 
ATOM   2999 C  C   . LEU   B 1 132 ? -48.82349 -0.44208  -62.47887 1.000 43.54826 ? 132 LEU   B C   1 
ATOM   3000 O  O   . LEU   B 1 132 ? -49.33560 -0.14095  -61.39514 1.000 42.34587 ? 132 LEU   B O   1 
ATOM   3001 C  CB  . LEU   B 1 132 ? -48.14291 1.45798   -63.97001 1.000 37.62921 ? 132 LEU   B CB  1 
ATOM   3002 C  CG  . LEU   B 1 132 ? -47.11598 2.41678   -64.58045 1.000 41.74709 ? 132 LEU   B CG  1 
ATOM   3003 C  CD1 . LEU   B 1 132 ? -46.59388 1.88654   -65.90869 1.000 41.30381 ? 132 LEU   B CD1 1 
ATOM   3004 C  CD2 . LEU   B 1 132 ? -47.70479 3.80873   -64.75461 1.000 41.55629 ? 132 LEU   B CD2 1 
ATOM   3005 N  N   . LYS   B 1 133 ? -49.26089 -1.46965  -63.21193 1.000 44.70772 ? 133 LYS   B N   1 
ATOM   3006 C  CA  . LYS   B 1 133 ? -50.36333 -2.30779  -62.75156 1.000 41.52046 ? 133 LYS   B CA  1 
ATOM   3007 C  C   . LYS   B 1 133 ? -49.89930 -3.34350  -61.74018 1.000 39.49470 ? 133 LYS   B C   1 
ATOM   3008 O  O   . LYS   B 1 133 ? -50.65580 -3.70126  -60.83017 1.000 45.82744 ? 133 LYS   B O   1 
ATOM   3009 C  CB  . LYS   B 1 133 ? -51.02185 -3.02364  -63.93430 1.000 42.65422 ? 133 LYS   B CB  1 
ATOM   3010 C  CG  . LYS   B 1 133 ? -51.08096 -2.19940  -65.21559 1.000 51.31776 ? 133 LYS   B CG  1 
ATOM   3011 C  CD  . LYS   B 1 133 ? -51.84802 -0.90197  -64.99710 1.000 58.21556 ? 133 LYS   B CD  1 
ATOM   3012 C  CE  . LYS   B 1 133 ? -51.29729 0.22709   -65.85900 1.000 59.31081 ? 133 LYS   B CE  1 
ATOM   3013 N  NZ  . LYS   B 1 133 ? -51.32794 1.52219   -65.12492 1.000 55.34810 ? 133 LYS   B NZ  1 
ATOM   3014 N  N   . THR   B 1 134 ? -48.67414 -3.84693  -61.90038 1.000 38.56165 ? 134 THR   B N   1 
ATOM   3015 C  CA  . THR   B 1 134 ? -48.15710 -4.85711  -60.98600 1.000 36.24598 ? 134 THR   B CA  1 
ATOM   3016 C  C   . THR   B 1 134 ? -47.92891 -4.27367  -59.59855 1.000 42.40150 ? 134 THR   B C   1 
ATOM   3017 O  O   . THR   B 1 134 ? -48.23200 -4.91904  -58.58817 1.000 39.16408 ? 134 THR   B O   1 
ATOM   3018 C  CB  . THR   B 1 134 ? -46.86009 -5.44592  -61.54408 1.000 36.05408 ? 134 THR   B CB  1 
ATOM   3019 O  OG1 . THR   B 1 134 ? -47.09093 -5.94467  -62.86820 1.000 38.40979 ? 134 THR   B OG1 1 
ATOM   3020 C  CG2 . THR   B 1 134 ? -46.35872 -6.58051  -60.66308 1.000 37.74170 ? 134 THR   B CG2 1 
ATOM   3021 N  N   . PHE   B 1 135 ? -47.41697 -3.04478  -59.53007 1.000 38.04164 ? 135 PHE   B N   1 
ATOM   3022 C  CA  . PHE   B 1 135 ? -47.06394 -2.41282  -58.26657 1.000 36.69962 ? 135 PHE   B CA  1 
ATOM   3023 C  C   . PHE   B 1 135 ? -47.95353 -1.21401  -57.94540 1.000 36.66021 ? 135 PHE   B C   1 
ATOM   3024 O  O   . PHE   B 1 135 ? -47.59901 -0.39875  -57.08827 1.000 35.22412 ? 135 PHE   B O   1 
ATOM   3025 C  CB  . PHE   B 1 135 ? -45.58664 -2.01403  -58.28471 1.000 35.26516 ? 135 PHE   B CB  1 
ATOM   3026 C  CG  . PHE   B 1 135 ? -44.64429 -3.19069  -58.36784 1.000 27.57930 ? 135 PHE   B CG  1 
ATOM   3027 C  CD1 . PHE   B 1 135 ? -44.43946 -4.00753  -57.26716 1.000 31.72779 ? 135 PHE   B CD1 1 
ATOM   3028 C  CD2 . PHE   B 1 135 ? -43.97277 -3.48624  -59.54611 1.000 30.32531 ? 135 PHE   B CD2 1 
ATOM   3029 C  CE1 . PHE   B 1 135 ? -43.58168 -5.09236  -57.33516 1.000 30.57498 ? 135 PHE   B CE1 1 
ATOM   3030 C  CE2 . PHE   B 1 135 ? -43.11132 -4.57223  -59.62015 1.000 30.59370 ? 135 PHE   B CE2 1 
ATOM   3031 C  CZ  . PHE   B 1 135 ? -42.91712 -5.37454  -58.51191 1.000 36.82585 ? 135 PHE   B CZ  1 
ATOM   3032 N  N   . LYS   B 1 136 ? -49.10383 -1.10172  -58.61443 1.000 36.39763 ? 136 LYS   B N   1 
ATOM   3033 C  CA  . LYS   B 1 136 ? -50.11411 -0.07549  -58.33370 1.000 37.03947 ? 136 LYS   B CA  1 
ATOM   3034 C  C   . LYS   B 1 136 ? -49.48300 1.31224   -58.22034 1.000 43.44835 ? 136 LYS   B C   1 
ATOM   3035 O  O   . LYS   B 1 136 ? -49.68818 2.04867   -57.25188 1.000 38.67841 ? 136 LYS   B O   1 
ATOM   3036 C  CB  . LYS   B 1 136 ? -50.91551 -0.43027  -57.07762 1.000 46.92703 ? 136 LYS   B CB  1 
ATOM   3037 C  CG  . LYS   B 1 136 ? -52.20727 0.37638   -56.86721 1.000 48.37665 ? 136 LYS   B CG  1 
ATOM   3038 C  CD  . LYS   B 1 136 ? -53.11111 0.41329   -58.09403 1.000 46.94376 ? 136 LYS   B CD  1 
ATOM   3039 C  CE  . LYS   B 1 136 ? -54.38282 1.20902   -57.79528 1.000 53.19977 ? 136 LYS   B CE  1 
ATOM   3040 N  NZ  . LYS   B 1 136 ? -54.26363 2.68117   -57.99341 1.000 48.18196 ? 136 LYS   B NZ  1 
ATOM   3041 N  N   . ILE   B 1 137 ? -48.68944 1.66582   -59.22823 1.000 40.43725 ? 137 ILE   B N   1 
ATOM   3042 C  CA  . ILE   B 1 137 ? -48.05891 2.97581   -59.30928 1.000 36.19351 ? 137 ILE   B CA  1 
ATOM   3043 C  C   . ILE   B 1 137 ? -49.01151 3.90208   -60.07140 1.000 36.45892 ? 137 ILE   B C   1 
ATOM   3044 O  O   . ILE   B 1 137 ? -49.24685 3.66465   -61.26846 1.000 40.19947 ? 137 ILE   B O   1 
ATOM   3045 C  CB  . ILE   B 1 137 ? -46.69260 2.90959   -60.00001 1.000 36.39031 ? 137 ILE   B CB  1 
ATOM   3046 C  CG1 . ILE   B 1 137 ? -45.80745 1.85241   -59.33901 1.000 33.48175 ? 137 ILE   B CG1 1 
ATOM   3047 C  CG2 . ILE   B 1 137 ? -46.01762 4.27668   -59.97745 1.000 32.75837 ? 137 ILE   B CG2 1 
ATOM   3048 C  CD1 . ILE   B 1 137 ? -44.76980 1.27160   -60.27076 1.000 28.80573 ? 137 ILE   B CD1 1 
ATOM   3049 N  N   . PRO   B 1 138 ? -49.57698 4.92017   -59.43310 1.000 34.67597 ? 138 PRO   B N   1 
ATOM   3050 C  CA  . PRO   B 1 138 ? -50.33440 5.92183   -60.19265 1.000 37.53035 ? 138 PRO   B CA  1 
ATOM   3051 C  C   . PRO   B 1 138 ? -49.44177 6.54824   -61.25195 1.000 40.00061 ? 138 PRO   B C   1 
ATOM   3052 O  O   . PRO   B 1 138 ? -48.29408 6.90990   -60.98209 1.000 29.15127 ? 138 PRO   B O   1 
ATOM   3053 C  CB  . PRO   B 1 138 ? -50.75434 6.93773   -59.12370 1.000 33.59946 ? 138 PRO   B CB  1 
ATOM   3054 C  CG  . PRO   B 1 138 ? -50.68864 6.19066   -57.83417 1.000 36.00252 ? 138 PRO   B CG  1 
ATOM   3055 C  CD  . PRO   B 1 138 ? -49.57060 5.20471   -57.98905 1.000 34.72168 ? 138 PRO   B CD  1 
ATOM   3056 N  N   . VAL   B 1 139 ? -49.96729 6.65032   -62.47483 1.000 36.74993 ? 139 VAL   B N   1 
ATOM   3057 C  CA  . VAL   B 1 139 ? -49.14990 7.15115   -63.57615 1.000 32.66480 ? 139 VAL   B CA  1 
ATOM   3058 C  C   . VAL   B 1 139 ? -48.70163 8.58079   -63.29775 1.000 35.56760 ? 139 VAL   B C   1 
ATOM   3059 O  O   . VAL   B 1 139 ? -47.57045 8.96388   -63.61857 1.000 36.73244 ? 139 VAL   B O   1 
ATOM   3060 C  CB  . VAL   B 1 139 ? -49.90440 7.02632   -64.91548 1.000 41.43598 ? 139 VAL   B CB  1 
ATOM   3061 C  CG1 . VAL   B 1 139 ? -51.10359 7.96539   -64.97052 1.000 35.09009 ? 139 VAL   B CG1 1 
ATOM   3062 C  CG2 . VAL   B 1 139 ? -48.95757 7.27963   -66.08241 1.000 34.34279 ? 139 VAL   B CG2 1 
ATOM   3063 N  N   . ASP   B 1 140 ? -49.56074 9.37972   -62.65866 1.000 31.99579 ? 140 ASP   B N   1 
ATOM   3064 C  CA  . ASP   B 1 140 ? -49.17407 10.74334  -62.31519 1.000 36.71473 ? 140 ASP   B CA  1 
ATOM   3065 C  C   . ASP   B 1 140 ? -48.07119 10.76091  -61.26615 1.000 34.27320 ? 140 ASP   B C   1 
ATOM   3066 O  O   . ASP   B 1 140 ? -47.19882 11.63577  -61.29797 1.000 33.00147 ? 140 ASP   B O   1 
ATOM   3067 C  CB  . ASP   B 1 140 ? -50.39032 11.52921  -61.82568 1.000 35.37700 ? 140 ASP   B CB  1 
ATOM   3068 C  CG  . ASP   B 1 140 ? -51.04463 10.89460  -60.61602 1.000 42.55367 ? 140 ASP   B CG  1 
ATOM   3069 O  OD1 . ASP   B 1 140 ? -51.27409 9.66705   -60.63852 1.000 41.98991 ? 140 ASP   B OD1 1 
ATOM   3070 O  OD2 . ASP   B 1 140 ? -51.32173 11.62300  -59.63959 1.000 39.69136 ? 140 ASP   B OD2 1 
ATOM   3071 N  N   . THR   B 1 141 ? -48.09327 9.80908   -60.33074 1.000 34.33799 ? 141 THR   B N   1 
ATOM   3072 C  CA  . THR   B 1 141 ? -47.00497 9.69489   -59.36600 1.000 33.00144 ? 141 THR   B CA  1 
ATOM   3073 C  C   . THR   B 1 141 ? -45.71934 9.25537   -60.04974 1.000 30.71746 ? 141 THR   B C   1 
ATOM   3074 O  O   . THR   B 1 141 ? -44.62997 9.73787   -59.71634 1.000 28.64228 ? 141 THR   B O   1 
ATOM   3075 C  CB  . THR   B 1 141 ? -47.38718 8.70971   -58.26347 1.000 33.67151 ? 141 THR   B CB  1 
ATOM   3076 O  OG1 . THR   B 1 141 ? -48.60422 9.14054   -57.64339 1.000 26.90156 ? 141 THR   B OG1 1 
ATOM   3077 C  CG2 . THR   B 1 141 ? -46.28830 8.63030   -57.21431 1.000 30.87052 ? 141 THR   B CG2 1 
ATOM   3078 N  N   . LEU   B 1 142 ? -45.83329 8.34047   -61.01133 1.000 28.97157 ? 142 LEU   B N   1 
ATOM   3079 C  CA  . LEU   B 1 142 ? -44.67279 7.91842   -61.78216 1.000 29.50570 ? 142 LEU   B CA  1 
ATOM   3080 C  C   . LEU   B 1 142 ? -44.06585 9.09633   -62.53936 1.000 32.45590 ? 142 LEU   B C   1 
ATOM   3081 O  O   . LEU   B 1 142 ? -42.86472 9.36846   -62.42738 1.000 32.43940 ? 142 LEU   B O   1 
ATOM   3082 C  CB  . LEU   B 1 142 ? -45.08505 6.78281   -62.72162 1.000 32.09502 ? 142 LEU   B CB  1 
ATOM   3083 C  CG  . LEU   B 1 142 ? -44.02789 6.00525   -63.49993 1.000 31.02984 ? 142 LEU   B CG  1 
ATOM   3084 C  CD1 . LEU   B 1 142 ? -43.71558 6.71831   -64.80493 1.000 39.20598 ? 142 LEU   B CD1 1 
ATOM   3085 C  CD2 . LEU   B 1 142 ? -42.77071 5.82059   -62.66126 1.000 28.30094 ? 142 LEU   B CD2 1 
ATOM   3086 N  N   . ILE   B 1 143 ? -44.89338 9.83666   -63.28051 1.000 27.64650 ? 143 ILE   B N   1 
ATOM   3087 C  CA  . ILE   B 1 143 ? -44.38886 10.95685  -64.07072 1.000 30.14467 ? 143 ILE   B CA  1 
ATOM   3088 C  C   . ILE   B 1 143 ? -43.83569 12.05179  -63.16539 1.000 28.61625 ? 143 ILE   B C   1 
ATOM   3089 O  O   . ILE   B 1 143 ? -42.80422 12.66285  -63.46921 1.000 25.72613 ? 143 ILE   B O   1 
ATOM   3090 C  CB  . ILE   B 1 143 ? -45.49352 11.49129  -65.00078 1.000 31.96744 ? 143 ILE   B CB  1 
ATOM   3091 C  CG1 . ILE   B 1 143 ? -45.99711 10.37761  -65.91911 1.000 29.49962 ? 143 ILE   B CG1 1 
ATOM   3092 C  CG2 . ILE   B 1 143 ? -44.97955 12.66210  -65.82928 1.000 28.90936 ? 143 ILE   B CG2 1 
ATOM   3093 C  CD1 . ILE   B 1 143 ? -44.89502 9.61389   -66.61468 1.000 38.68276 ? 143 ILE   B CD1 1 
ATOM   3094 N  N   . THR   B 1 144 ? -44.50407 12.31354  -62.03939 1.000 26.93928 ? 144 THR   B N   1 
ATOM   3095 C  CA  . THR   B 1 144 ? -44.02776 13.33787  -61.11429 1.000 26.19708 ? 144 THR   B CA  1 
ATOM   3096 C  C   . THR   B 1 144 ? -42.63398 13.00472  -60.59686 1.000 27.48286 ? 144 THR   B C   1 
ATOM   3097 O  O   . THR   B 1 144 ? -41.74311 13.86246  -60.58115 1.000 25.49336 ? 144 THR   B O   1 
ATOM   3098 C  CB  . THR   B 1 144 ? -45.00712 13.49469  -59.95118 1.000 32.16130 ? 144 THR   B CB  1 
ATOM   3099 O  OG1 . THR   B 1 144 ? -46.33697 13.64974  -60.46265 1.000 30.24948 ? 144 THR   B OG1 1 
ATOM   3100 C  CG2 . THR   B 1 144 ? -44.64599 14.71069  -59.11598 1.000 26.95639 ? 144 THR   B CG2 1 
ATOM   3101 N  N   . TYR   B 1 145 ? -42.42204 11.75653  -60.17541 1.000 23.77485 ? 145 TYR   B N   1 
ATOM   3102 C  CA  . TYR   B 1 145 ? -41.10751 11.37588  -59.67208 1.000 26.80701 ? 145 TYR   B CA  1 
ATOM   3103 C  C   . TYR   B 1 145 ? -40.05996 11.42126  -60.77530 1.000 25.13616 ? 145 TYR   B C   1 
ATOM   3104 O  O   . TYR   B 1 145 ? -38.97857 11.99229  -60.59207 1.000 27.15730 ? 145 TYR   B O   1 
ATOM   3105 C  CB  . TYR   B 1 145 ? -41.14441 9.98373   -59.04755 1.000 24.38141 ? 145 TYR   B CB  1 
ATOM   3106 C  CG  . TYR   B 1 145 ? -39.76211 9.52031   -58.65618 1.000 22.59722 ? 145 TYR   B CG  1 
ATOM   3107 C  CD1 . TYR   B 1 145 ? -39.15752 9.99622   -57.50271 1.000 21.58136 ? 145 TYR   B CD1 1 
ATOM   3108 C  CD2 . TYR   B 1 145 ? -39.04819 8.63489   -59.45507 1.000 19.17266 ? 145 TYR   B CD2 1 
ATOM   3109 C  CE1 . TYR   B 1 145 ? -37.89011 9.59312   -57.14408 1.000 18.00798 ? 145 TYR   B CE1 1 
ATOM   3110 C  CE2 . TYR   B 1 145 ? -37.77735 8.22578   -59.10416 1.000 19.17574 ? 145 TYR   B CE2 1 
ATOM   3111 C  CZ  . TYR   B 1 145 ? -37.20438 8.70818   -57.94670 1.000 18.05385 ? 145 TYR   B CZ  1 
ATOM   3112 O  OH  . TYR   B 1 145 ? -35.93992 8.30679   -57.58638 1.000 16.02607 ? 145 TYR   B OH  1 
ATOM   3113 N  N   . LEU   B 1 146 ? -40.35316 10.80076  -61.92170 1.000 27.48667 ? 146 LEU   B N   1 
ATOM   3114 C  CA  . LEU   B 1 146 ? -39.38191 10.77025  -63.01005 1.000 24.02554 ? 146 LEU   B CA  1 
ATOM   3115 C  C   . LEU   B 1 146 ? -38.96190 12.17131  -63.41854 1.000 27.78422 ? 146 LEU   B C   1 
ATOM   3116 O  O   . LEU   B 1 146 ? -37.78336 12.41804  -63.69687 1.000 26.45964 ? 146 LEU   B O   1 
ATOM   3117 C  CB  . LEU   B 1 146 ? -39.94893 10.03413  -64.21803 1.000 21.86680 ? 146 LEU   B CB  1 
ATOM   3118 C  CG  . LEU   B 1 146 ? -40.10779 8.52828   -64.11204 1.000 22.34274 ? 146 LEU   B CG  1 
ATOM   3119 C  CD1 . LEU   B 1 146 ? -40.66430 8.03699   -65.43232 1.000 25.01695 ? 146 LEU   B CD1 1 
ATOM   3120 C  CD2 . LEU   B 1 146 ? -38.76915 7.88752   -63.77547 1.000 19.78709 ? 146 LEU   B CD2 1 
ATOM   3121 N  N   . MET   B 1 147 ? -39.91663 13.10115  -63.46811 1.000 23.91608 ? 147 MET   B N   1 
ATOM   3122 C  CA  . MET   B 1 147 ? -39.59133 14.48049  -63.81137 1.000 27.39365 ? 147 MET   B CA  1 
ATOM   3123 C  C   . MET   B 1 147 ? -38.66543 15.09932  -62.77197 1.000 27.73587 ? 147 MET   B C   1 
ATOM   3124 O  O   . MET   B 1 147 ? -37.65715 15.72623  -63.11709 1.000 26.38088 ? 147 MET   B O   1 
ATOM   3125 C  CB  . MET   B 1 147 ? -40.87518 15.29692  -63.95189 1.000 29.04617 ? 147 MET   B CB  1 
ATOM   3126 C  CG  . MET   B 1 147 ? -41.65548 15.00924  -65.22170 1.000 36.22115 ? 147 MET   B CG  1 
ATOM   3127 S  SD  . MET   B 1 147 ? -41.23740 16.17834  -66.52322 1.000 61.67883 ? 147 MET   B SD  1 
ATOM   3128 C  CE  . MET   B 1 147 ? -41.54975 17.72722  -65.68360 1.000 42.55408 ? 147 MET   B CE  1 
ATOM   3129 N  N   . THR   B 1 148 ? -38.99089 14.92879  -61.48829 1.000 22.90681 ? 148 THR   B N   1 
ATOM   3130 C  CA  . THR   B 1 148 ? -38.14167 15.46997  -60.43140 1.000 26.14946 ? 148 THR   B CA  1 
ATOM   3131 C  C   . THR   B 1 148 ? -36.76435 14.81891  -60.45240 1.000 23.00549 ? 148 THR   B C   1 
ATOM   3132 O  O   . THR   B 1 148 ? -35.73980 15.50083  -60.32939 1.000 21.98107 ? 148 THR   B O   1 
ATOM   3133 C  CB  . THR   B 1 148 ? -38.80696 15.27497  -59.06893 1.000 26.37625 ? 148 THR   B CB  1 
ATOM   3134 O  OG1 . THR   B 1 148 ? -40.21651 15.50530  -59.18713 1.000 34.76189 ? 148 THR   B OG1 1 
ATOM   3135 C  CG2 . THR   B 1 148 ? -38.22371 16.24440  -58.05097 1.000 25.85869 ? 148 THR   B CG2 1 
ATOM   3136 N  N   . LEU   B 1 149 ? -36.72382 13.49274  -60.60772 1.000 21.03481 ? 149 LEU   B N   1 
ATOM   3137 C  CA  . LEU   B 1 149 ? -35.44827 12.79026  -60.70707 1.000 20.35531 ? 149 LEU   B CA  1 
ATOM   3138 C  C   . LEU   B 1 149 ? -34.61628 13.33118  -61.86190 1.000 21.16605 ? 149 LEU   B C   1 
ATOM   3139 O  O   . LEU   B 1 149 ? -33.43293 13.64978  -61.69709 1.000 19.06328 ? 149 LEU   B O   1 
ATOM   3140 C  CB  . LEU   B 1 149 ? -35.68825 11.29062  -60.87994 1.000 20.29430 ? 149 LEU   B CB  1 
ATOM   3141 C  CG  . LEU   B 1 149 ? -34.41531 10.45751  -61.03717 1.000 20.73422 ? 149 LEU   B CG  1 
ATOM   3142 C  CD1 . LEU   B 1 149 ? -33.66248 10.38775  -59.71796 1.000 17.55129 ? 149 LEU   B CD1 1 
ATOM   3143 C  CD2 . LEU   B 1 149 ? -34.72177 9.06486   -61.56748 1.000 18.35747 ? 149 LEU   B CD2 1 
ATOM   3144 N  N   . GLU   B 1 150 ? -35.22760 13.44554  -63.04273 1.000 25.21175 ? 150 GLU   B N   1 
ATOM   3145 C  CA  . GLU   B 1 150 ? -34.51718 13.96753  -64.20441 1.000 21.51484 ? 150 GLU   B CA  1 
ATOM   3146 C  C   . GLU   B 1 150 ? -34.02782 15.38955  -63.95915 1.000 21.52004 ? 150 GLU   B C   1 
ATOM   3147 O  O   . GLU   B 1 150 ? -32.94165 15.76816  -64.41456 1.000 21.74584 ? 150 GLU   B O   1 
ATOM   3148 C  CB  . GLU   B 1 150 ? -35.42679 13.90965  -65.42981 1.000 24.97471 ? 150 GLU   B CB  1 
ATOM   3149 C  CG  . GLU   B 1 150 ? -34.72513 14.17931  -66.73927 1.000 25.77663 ? 150 GLU   B CG  1 
ATOM   3150 C  CD  . GLU   B 1 150 ? -35.44581 13.55684  -67.91370 1.000 26.84613 ? 150 GLU   B CD  1 
ATOM   3151 O  OE1 . GLU   B 1 150 ? -36.68718 13.43285  -67.85720 1.000 28.06069 ? 150 GLU   B OE1 1 
ATOM   3152 O  OE2 . GLU   B 1 150 ? -34.76730 13.17959  -68.88858 1.000 21.76066 ? 150 GLU   B OE2 1 
ATOM   3153 N  N   . ASP   B 1 151 ? -34.81231 16.18809  -63.22944 1.000 23.25769 ? 151 ASP   B N   1 
ATOM   3154 C  CA  . ASP   B 1 151 ? -34.40430 17.54949  -62.90232 1.000 23.96216 ? 151 ASP   B CA  1 
ATOM   3155 C  C   . ASP   B 1 151 ? -33.14040 17.59104  -62.05760 1.000 23.17306 ? 151 ASP   B C   1 
ATOM   3156 O  O   . ASP   B 1 151 ? -32.41749 18.59286  -62.09327 1.000 21.24409 ? 151 ASP   B O   1 
ATOM   3157 C  CB  . ASP   B 1 151 ? -35.52752 18.28067  -62.16567 1.000 24.50404 ? 151 ASP   B CB  1 
ATOM   3158 C  CG  . ASP   B 1 151 ? -36.66342 18.67793  -63.08208 1.000 26.87221 ? 151 ASP   B CG  1 
ATOM   3159 O  OD1 . ASP   B 1 151 ? -36.46302 18.67013  -64.31481 1.000 23.22733 ? 151 ASP   B OD1 1 
ATOM   3160 O  OD2 . ASP   B 1 151 ? -37.75231 19.01119  -62.56674 1.000 28.78404 ? 151 ASP   B OD2 1 
ATOM   3161 N  N   . HIS   B 1 152 ? -32.85806 16.53919  -61.29572 1.000 23.79739 ? 152 HIS   B N   1 
ATOM   3162 C  CA  . HIS   B 1 152 ? -31.67388 16.52130  -60.45221 1.000 20.09864 ? 152 HIS   B CA  1 
ATOM   3163 C  C   . HIS   B 1 152 ? -30.45307 15.95023  -61.15909 1.000 19.49635 ? 152 HIS   B C   1 
ATOM   3164 O  O   . HIS   B 1 152 ? -29.38545 15.87220  -60.54849 1.000 18.26549 ? 152 HIS   B O   1 
ATOM   3165 C  CB  . HIS   B 1 152 ? -31.96542 15.76145  -59.15418 1.000 20.44258 ? 152 HIS   B CB  1 
ATOM   3166 C  CG  . HIS   B 1 152 ? -32.75805 16.56366  -58.16937 1.000 17.85663 ? 152 HIS   B CG  1 
ATOM   3167 N  ND1 . HIS   B 1 152 ? -34.11991 16.74350  -58.28141 1.000 22.16935 ? 152 HIS   B ND1 1 
ATOM   3168 C  CD2 . HIS   B 1 152 ? -32.37483 17.26685  -57.07747 1.000 21.63760 ? 152 HIS   B CD2 1 
ATOM   3169 C  CE1 . HIS   B 1 152 ? -34.54394 17.50963  -57.29227 1.000 21.65707 ? 152 HIS   B CE1 1 
ATOM   3170 N  NE2 . HIS   B 1 152 ? -33.50506 17.83948  -56.54638 1.000 25.91591 ? 152 HIS   B NE2 1 
ATOM   3171 N  N   . TYR   B 1 153 ? -30.58004 15.55997  -62.42435 1.000 21.34555 ? 153 TYR   B N   1 
ATOM   3172 C  CA  . TYR   B 1 153 ? -29.41442 15.38189  -63.27692 1.000 18.72250 ? 153 TYR   B CA  1 
ATOM   3173 C  C   . TYR   B 1 153 ? -29.02498 16.73163  -63.86799 1.000 22.95594 ? 153 TYR   B C   1 
ATOM   3174 O  O   . TYR   B 1 153 ? -29.88509 17.50757  -64.29507 1.000 21.79609 ? 153 TYR   B O   1 
ATOM   3175 C  CB  . TYR   B 1 153 ? -29.70137 14.36959  -64.38770 1.000 15.80363 ? 153 TYR   B CB  1 
ATOM   3176 C  CG  . TYR   B 1 153 ? -29.61011 12.92215  -63.95009 1.000 15.25723 ? 153 TYR   B CG  1 
ATOM   3177 C  CD1 . TYR   B 1 153 ? -28.39957 12.24050  -63.98758 1.000 19.35363 ? 153 TYR   B CD1 1 
ATOM   3178 C  CD2 . TYR   B 1 153 ? -30.73289 12.23685  -63.50354 1.000 14.43914 ? 153 TYR   B CD2 1 
ATOM   3179 C  CE1 . TYR   B 1 153 ? -28.31100 10.91795  -63.59545 1.000 15.36949 ? 153 TYR   B CE1 1 
ATOM   3180 C  CE2 . TYR   B 1 153 ? -30.65282 10.91360  -63.10522 1.000 11.47659 ? 153 TYR   B CE2 1 
ATOM   3181 C  CZ  . TYR   B 1 153 ? -29.43829 10.26033  -63.15117 1.000 13.75985 ? 153 TYR   B CZ  1 
ATOM   3182 O  OH  . TYR   B 1 153 ? -29.34794 8.94366   -62.75744 1.000 11.94362 ? 153 TYR   B OH  1 
ATOM   3183 N  N   . HIS   B 1 154 ? -27.72438 17.01814  -63.87367 1.000 17.61316 ? 154 HIS   B N   1 
ATOM   3184 C  CA  . HIS   B 1 154 ? -27.23524 18.34255  -64.24269 1.000 19.62741 ? 154 HIS   B CA  1 
ATOM   3185 C  C   . HIS   B 1 154 ? -27.25151 18.50873  -65.75789 1.000 19.98477 ? 154 HIS   B C   1 
ATOM   3186 O  O   . HIS   B 1 154 ? -26.60652 17.74116  -66.48041 1.000 17.49580 ? 154 HIS   B O   1 
ATOM   3187 C  CB  . HIS   B 1 154 ? -25.82312 18.56684  -63.70711 1.000 20.01439 ? 154 HIS   B CB  1 
ATOM   3188 C  CG  . HIS   B 1 154 ? -25.72654 18.58876  -62.21288 1.000 20.90761 ? 154 HIS   B CG  1 
ATOM   3189 N  ND1 . HIS   B 1 154 ? -24.71699 19.25177  -61.54913 1.000 24.07081 ? 154 HIS   B ND1 1 
ATOM   3190 C  CD2 . HIS   B 1 154 ? -26.49682 18.02100  -61.25449 1.000 20.11499 ? 154 HIS   B CD2 1 
ATOM   3191 C  CE1 . HIS   B 1 154 ? -24.87428 19.09978  -60.24661 1.000 23.60770 ? 154 HIS   B CE1 1 
ATOM   3192 N  NE2 . HIS   B 1 154 ? -25.94663 18.35655  -60.04090 1.000 18.70097 ? 154 HIS   B NE2 1 
ATOM   3193 N  N   . ALA   B 1 155 ? -27.97008 19.52665  -66.23762 1.000 25.55269 ? 155 ALA   B N   1 
ATOM   3194 C  CA  . ALA   B 1 155 ? -28.01129 19.78329  -67.67284 1.000 24.52668 ? 155 ALA   B CA  1 
ATOM   3195 C  C   . ALA   B 1 155 ? -26.65741 20.22849  -68.20699 1.000 24.64225 ? 155 ALA   B C   1 
ATOM   3196 O  O   . ALA   B 1 155 ? -26.36517 20.03169  -69.39153 1.000 27.52678 ? 155 ALA   B O   1 
ATOM   3197 C  CB  . ALA   B 1 155 ? -29.07075 20.83704  -67.99314 1.000 26.92528 ? 155 ALA   B CB  1 
ATOM   3198 N  N   . ASP   B 1 156 ? -25.82103 20.83016  -67.36195 1.000 24.49658 ? 156 ASP   B N   1 
ATOM   3199 C  CA  . ASP   B 1 156 ? -24.53875 21.36085  -67.80041 1.000 20.97732 ? 156 ASP   B CA  1 
ATOM   3200 C  C   . ASP   B 1 156 ? -23.38948 20.38123  -67.58567 1.000 21.04549 ? 156 ASP   B C   1 
ATOM   3201 O  O   . ASP   B 1 156 ? -22.22252 20.78647  -67.63863 1.000 20.10184 ? 156 ASP   B O   1 
ATOM   3202 C  CB  . ASP   B 1 156 ? -24.24716 22.68822  -67.09671 1.000 16.56661 ? 156 ASP   B CB  1 
ATOM   3203 C  CG  . ASP   B 1 156 ? -24.06121 22.53111  -65.60259 1.000 25.97249 ? 156 ASP   B CG  1 
ATOM   3204 O  OD1 . ASP   B 1 156 ? -24.55118 21.53292  -65.03346 1.000 29.62541 ? 156 ASP   B OD1 1 
ATOM   3205 O  OD2 . ASP   B 1 156 ? -23.41455 23.40919  -64.99638 1.000 32.08875 ? 156 ASP   B OD2 1 
ATOM   3206 N  N   . VAL   B 1 157 ? -23.69239 19.10911  -67.34288 1.000 19.66757 ? 157 VAL   B N   1 
ATOM   3207 C  CA  . VAL   B 1 157 ? -22.68756 18.05556  -67.26235 1.000 18.33701 ? 157 VAL   B CA  1 
ATOM   3208 C  C   . VAL   B 1 157 ? -22.74409 17.25232  -68.55380 1.000 19.49850 ? 157 VAL   B C   1 
ATOM   3209 O  O   . VAL   B 1 157 ? -23.80932 16.75357  -68.93933 1.000 19.09072 ? 157 VAL   B O   1 
ATOM   3210 C  CB  . VAL   B 1 157 ? -22.90860 17.16258  -66.02976 1.000 18.70946 ? 157 VAL   B CB  1 
ATOM   3211 C  CG1 . VAL   B 1 157 ? -22.05940 15.91203  -66.12334 1.000 17.35530 ? 157 VAL   B CG1 1 
ATOM   3212 C  CG2 . VAL   B 1 157 ? -22.56092 17.92891  -64.76556 1.000 17.42255 ? 157 VAL   B CG2 1 
ATOM   3213 N  N   . ALA   B 1 158 ? -21.59287 17.12215  -69.21895 1.000 19.16112 ? 158 ALA   B N   1 
ATOM   3214 C  CA  . ALA   B 1 158 ? -21.57898 16.68188  -70.61114 1.000 22.00456 ? 158 ALA   B CA  1 
ATOM   3215 C  C   . ALA   B 1 158 ? -21.92596 15.20312  -70.75132 1.000 22.36581 ? 158 ALA   B C   1 
ATOM   3216 O  O   . ALA   B 1 158 ? -22.60685 14.81346  -71.70684 1.000 21.94010 ? 158 ALA   B O   1 
ATOM   3217 C  CB  . ALA   B 1 158 ? -20.21683 16.97884  -71.23764 1.000 21.81808 ? 158 ALA   B CB  1 
ATOM   3218 N  N   . TYR   B 1 159 ? -21.46914 14.36003  -69.82540 1.000 17.80323 ? 159 TYR   B N   1 
ATOM   3219 C  CA  . TYR   B 1 159 ? -21.74709 12.93035  -69.90103 1.000 14.82931 ? 159 TYR   B CA  1 
ATOM   3220 C  C   . TYR   B 1 159 ? -22.73005 12.47094  -68.83205 1.000 14.58705 ? 159 TYR   B C   1 
ATOM   3221 O  O   . TYR   B 1 159 ? -23.79297 11.93748  -69.15965 1.000 14.94269 ? 159 TYR   B O   1 
ATOM   3222 C  CB  . TYR   B 1 159 ? -20.44672 12.11993  -69.80403 1.000 13.95330 ? 159 TYR   B CB  1 
ATOM   3223 C  CG  . TYR   B 1 159 ? -20.65288 10.62347  -69.92167 1.000 14.64118 ? 159 TYR   B CG  1 
ATOM   3224 C  CD1 . TYR   B 1 159 ? -20.87911 9.83859   -68.79521 1.000 11.74867 ? 159 TYR   B CD1 1 
ATOM   3225 C  CD2 . TYR   B 1 159 ? -20.62375 9.99737   -71.16072 1.000 14.64498 ? 159 TYR   B CD2 1 
ATOM   3226 C  CE1 . TYR   B 1 159 ? -21.06856 8.47443   -68.90198 1.000 14.74799 ? 159 TYR   B CE1 1 
ATOM   3227 C  CE2 . TYR   B 1 159 ? -20.81156 8.63451   -71.27723 1.000 13.79486 ? 159 TYR   B CE2 1 
ATOM   3228 C  CZ  . TYR   B 1 159 ? -21.03362 7.87759   -70.14544 1.000 18.58708 ? 159 TYR   B CZ  1 
ATOM   3229 O  OH  . TYR   B 1 159 ? -21.22147 6.51867   -70.25547 1.000 14.71350 ? 159 TYR   B OH  1 
ATOM   3230 N  N   . HIS   B 1 160 ? -22.39883 12.65060  -67.55287 1.000 15.35891 ? 160 HIS   B N   1 
ATOM   3231 C  CA  . HIS   B 1 160 ? -23.20112 12.09416  -66.46258 1.000 13.74445 ? 160 HIS   B CA  1 
ATOM   3232 C  C   . HIS   B 1 160 ? -24.44055 12.96138  -66.23646 1.000 14.22971 ? 160 HIS   B C   1 
ATOM   3233 O  O   . HIS   B 1 160 ? -24.59951 13.64684  -65.22399 1.000 14.57712 ? 160 HIS   B O   1 
ATOM   3234 C  CB  . HIS   B 1 160 ? -22.35865 11.95763  -65.20331 1.000 11.74034 ? 160 HIS   B CB  1 
ATOM   3235 C  CG  . HIS   B 1 160 ? -21.30457 10.89973  -65.30423 1.000 13.54131 ? 160 HIS   B CG  1 
ATOM   3236 N  ND1 . HIS   B 1 160 ? -19.96077 11.19078  -65.40511 1.000 12.44663 ? 160 HIS   B ND1 1 
ATOM   3237 C  CD2 . HIS   B 1 160 ? -21.40075 9.54958   -65.34063 1.000 13.18832 ? 160 HIS   B CD2 1 
ATOM   3238 C  CE1 . HIS   B 1 160 ? -19.27413 10.06501  -65.48895 1.000 13.34814 ? 160 HIS   B CE1 1 
ATOM   3239 N  NE2 . HIS   B 1 160 ? -20.12428 9.05471   -65.45241 1.000 12.86344 ? 160 HIS   B NE2 1 
ATOM   3240 N  N   . ASN   B 1 161 ? -25.34217 12.90389  -67.21637 1.000 14.97281 ? 161 ASN   B N   1 
ATOM   3241 C  CA  . ASN   B 1 161 ? -26.58467 13.66320  -67.17639 1.000 13.31636 ? 161 ASN   B CA  1 
ATOM   3242 C  C   . ASN   B 1 161 ? -27.78367 12.75793  -67.42500 1.000 16.55501 ? 161 ASN   B C   1 
ATOM   3243 O  O   . ASN   B 1 161 ? -27.66478 11.52935  -67.37896 1.000 16.05102 ? 161 ASN   B O   1 
ATOM   3244 C  CB  . ASN   B 1 161 ? -26.54719 14.80066  -68.20022 1.000 16.95315 ? 161 ASN   B CB  1 
ATOM   3245 C  CG  . ASN   B 1 161 ? -26.26957 14.31186  -69.61353 1.000 16.03974 ? 161 ASN   B CG  1 
ATOM   3246 O  OD1 . ASN   B 1 161 ? -26.89166 13.36549  -70.09589 1.000 14.44641 ? 161 ASN   B OD1 1 
ATOM   3247 N  ND2 . ASN   B 1 161 ? -25.31569 14.95155  -70.27881 1.000 12.85797 ? 161 ASN   B ND2 1 
ATOM   3248 N  N   . ASN   B 1 162 ? -28.93898 13.36127  -67.71046 1.000 16.51214 ? 162 ASN   B N   1 
ATOM   3249 C  CA  . ASN   B 1 162 ? -30.16593 12.58522  -67.84866 1.000 17.35021 ? 162 ASN   B CA  1 
ATOM   3250 C  C   . ASN   B 1 162 ? -30.13020 11.66786  -69.06453 1.000 20.27639 ? 162 ASN   B C   1 
ATOM   3251 O  O   . ASN   B 1 162 ? -30.80827 10.63423  -69.07578 1.000 17.97236 ? 162 ASN   B O   1 
ATOM   3252 C  CB  . ASN   B 1 162 ? -31.36900 13.52301  -67.92375 1.000 19.99890 ? 162 ASN   B CB  1 
ATOM   3253 C  CG  . ASN   B 1 162 ? -31.23518 14.54770  -69.02791 1.000 26.39129 ? 162 ASN   B CG  1 
ATOM   3254 O  OD1 . ASN   B 1 162 ? -30.12667 14.93643  -69.39559 1.000 26.32042 ? 162 ASN   B OD1 1 
ATOM   3255 N  ND2 . ASN   B 1 162 ? -32.36518 14.99342  -69.56402 1.000 23.15369 ? 162 ASN   B ND2 1 
ATOM   3256 N  N   . ILE   B 1 163 ? -29.35716 12.01966  -70.09512 1.000 15.82151 ? 163 ILE   B N   1 
ATOM   3257 C  CA  . ILE   B 1 163 ? -29.27877 11.15662  -71.27046 1.000 19.32776 ? 163 ILE   B CA  1 
ATOM   3258 C  C   . ILE   B 1 163 ? -28.53899 9.86860   -70.93565 1.000 17.60589 ? 163 ILE   B C   1 
ATOM   3259 O  O   . ILE   B 1 163 ? -28.93346 8.77951   -71.36994 1.000 17.15736 ? 163 ILE   B O   1 
ATOM   3260 C  CB  . ILE   B 1 163 ? -28.61880 11.89342  -72.44934 1.000 19.80482 ? 163 ILE   B CB  1 
ATOM   3261 C  CG1 . ILE   B 1 163 ? -29.25222 13.26810  -72.65142 1.000 21.36749 ? 163 ILE   B CG1 1 
ATOM   3262 C  CG2 . ILE   B 1 163 ? -28.75459 11.07717  -73.72325 1.000 18.19546 ? 163 ILE   B CG2 1 
ATOM   3263 C  CD1 . ILE   B 1 163 ? -28.55858 14.09393  -73.71424 1.000 22.54492 ? 163 ILE   B CD1 1 
ATOM   3264 N  N   . HIS   B 1 164 ? -27.45497 9.96923   -70.16221 1.000 14.32476 ? 164 HIS   B N   1 
ATOM   3265 C  CA  . HIS   B 1 164 ? -26.73687 8.77011   -69.74314 1.000 18.88922 ? 164 HIS   B CA  1 
ATOM   3266 C  C   . HIS   B 1 164 ? -27.60421 7.89667   -68.84635 1.000 14.78916 ? 164 HIS   B C   1 
ATOM   3267 O  O   . HIS   B 1 164 ? -27.57717 6.66500   -68.95294 1.000 15.40456 ? 164 HIS   B O   1 
ATOM   3268 C  CB  . HIS   B 1 164 ? -25.44207 9.15232   -69.02738 1.000 11.77622 ? 164 HIS   B CB  1 
ATOM   3269 C  CG  . HIS   B 1 164 ? -24.77859 8.00627   -68.32943 1.000 13.04436 ? 164 HIS   B CG  1 
ATOM   3270 N  ND1 . HIS   B 1 164 ? -24.14595 6.98620   -69.00674 1.000 15.79003 ? 164 HIS   B ND1 1 
ATOM   3271 C  CD2 . HIS   B 1 164 ? -24.65521 7.71622   -67.01264 1.000 14.04847 ? 164 HIS   B CD2 1 
ATOM   3272 C  CE1 . HIS   B 1 164 ? -23.65717 6.11986   -68.13730 1.000 13.74956 ? 164 HIS   B CE1 1 
ATOM   3273 N  NE2 . HIS   B 1 164 ? -23.95380 6.53871   -66.92036 1.000 14.07716 ? 164 HIS   B NE2 1 
ATOM   3274 N  N   . ALA   B 1 165 ? -28.38022 8.51729   -67.95484 1.000 17.51681 ? 165 ALA   B N   1 
ATOM   3275 C  CA  . ALA   B 1 165 ? -29.29144 7.75652   -67.10618 1.000 15.58781 ? 165 ALA   B CA  1 
ATOM   3276 C  C   . ALA   B 1 165 ? -30.33890 7.03446   -67.94310 1.000 16.85834 ? 165 ALA   B C   1 
ATOM   3277 O  O   . ALA   B 1 165 ? -30.56833 5.83159   -67.77025 1.000 17.64049 ? 165 ALA   B O   1 
ATOM   3278 C  CB  . ALA   B 1 165 ? -29.95697 8.68294   -66.08943 1.000 12.03363 ? 165 ALA   B CB  1 
ATOM   3279 N  N   . ALA   B 1 166 ? -30.98660 7.75901   -68.85997 1.000 21.55822 ? 166 ALA   B N   1 
ATOM   3280 C  CA  . ALA   B 1 166 ? -31.92805 7.12760   -69.77859 1.000 20.70812 ? 166 ALA   B CA  1 
ATOM   3281 C  C   . ALA   B 1 166 ? -31.26115 6.00672   -70.56265 1.000 17.97354 ? 166 ALA   B C   1 
ATOM   3282 O  O   . ALA   B 1 166 ? -31.86552 4.95406   -70.79881 1.000 21.48163 ? 166 ALA   B O   1 
ATOM   3283 C  CB  . ALA   B 1 166 ? -32.50975 8.17123   -70.73328 1.000 21.00294 ? 166 ALA   B CB  1 
ATOM   3284 N  N   . ASP   B 1 167 ? -30.00527 6.21197   -70.96242 1.000 19.35816 ? 167 ASP   B N   1 
ATOM   3285 C  CA  . ASP   B 1 167 ? -29.29649 5.19829   -71.73416 1.000 18.04068 ? 167 ASP   B CA  1 
ATOM   3286 C  C   . ASP   B 1 167 ? -29.03059 3.94885   -70.90198 1.000 20.56625 ? 167 ASP   B C   1 
ATOM   3287 O  O   . ASP   B 1 167 ? -29.16838 2.82564   -71.40023 1.000 17.22090 ? 167 ASP   B O   1 
ATOM   3288 C  CB  . ASP   B 1 167 ? -27.98989 5.77889   -72.27233 1.000 19.77934 ? 167 ASP   B CB  1 
ATOM   3289 C  CG  . ASP   B 1 167 ? -27.18940 4.77188   -73.06884 1.000 21.99537 ? 167 ASP   B CG  1 
ATOM   3290 O  OD1 . ASP   B 1 167 ? -27.80511 3.96692   -73.79896 1.000 21.65592 ? 167 ASP   B OD1 1 
ATOM   3291 O  OD2 . ASP   B 1 167 ? -25.94381 4.78542   -72.96409 1.000 19.70329 ? 167 ASP   B OD2 1 
ATOM   3292 N  N   . VAL   B 1 168 ? -28.64490 4.12094   -69.63521 1.000 17.14854 ? 168 VAL   B N   1 
ATOM   3293 C  CA  . VAL   B 1 168 ? -28.39167 2.96646   -68.77720 1.000 16.14381 ? 168 VAL   B CA  1 
ATOM   3294 C  C   . VAL   B 1 168 ? -29.69493 2.24851   -68.44968 1.000 15.44200 ? 168 VAL   B C   1 
ATOM   3295 O  O   . VAL   B 1 168 ? -29.74140 1.01342   -68.39282 1.000 17.57565 ? 168 VAL   B O   1 
ATOM   3296 C  CB  . VAL   B 1 168 ? -27.64306 3.39932   -67.50335 1.000 15.65806 ? 168 VAL   B CB  1 
ATOM   3297 C  CG1 . VAL   B 1 168 ? -27.51584 2.23463   -66.53392 1.000 16.35164 ? 168 VAL   B CG1 1 
ATOM   3298 C  CG2 . VAL   B 1 168 ? -26.27150 3.93373   -67.86134 1.000 14.24859 ? 168 VAL   B CG2 1 
ATOM   3299 N  N   . VAL   B 1 169 ? -30.77114 3.00743   -68.23067 1.000 16.02110 ? 169 VAL   B N   1 
ATOM   3300 C  CA  . VAL   B 1 169 ? -32.08390 2.40739   -67.99653 1.000 20.30926 ? 169 VAL   B CA  1 
ATOM   3301 C  C   . VAL   B 1 169 ? -32.46606 1.50139   -69.15839 1.000 20.02282 ? 169 VAL   B C   1 
ATOM   3302 O  O   . VAL   B 1 169 ? -32.73157 0.30697   -68.98099 1.000 19.59161 ? 169 VAL   B O   1 
ATOM   3303 C  CB  . VAL   B 1 169 ? -33.14376 3.49954   -67.77639 1.000 19.89565 ? 169 VAL   B CB  1 
ATOM   3304 C  CG1 . VAL   B 1 169 ? -34.53655 2.92644   -67.94398 1.000 25.92015 ? 169 VAL   B CG1 1 
ATOM   3305 C  CG2 . VAL   B 1 169 ? -32.99621 4.08982   -66.40986 1.000 21.80551 ? 169 VAL   B CG2 1 
ATOM   3306 N  N   . GLN   B 1 170 ? -32.49503 2.06324   -70.36850 1.000 22.44884 ? 170 GLN   B N   1 
ATOM   3307 C  CA  . GLN   B 1 170 ? -32.92064 1.29553   -71.53247 1.000 20.13286 ? 170 GLN   B CA  1 
ATOM   3308 C  C   . GLN   B 1 170 ? -31.98630 0.12168   -71.79211 1.000 21.56163 ? 170 GLN   B C   1 
ATOM   3309 O  O   . GLN   B 1 170 ? -32.42978 -0.95269  -72.21493 1.000 20.59606 ? 170 GLN   B O   1 
ATOM   3310 C  CB  . GLN   B 1 170 ? -32.99797 2.20832   -72.75460 1.000 22.44337 ? 170 GLN   B CB  1 
ATOM   3311 C  CG  . GLN   B 1 170 ? -33.57464 1.53821   -73.98455 1.000 25.61289 ? 170 GLN   B CG  1 
ATOM   3312 C  CD  . GLN   B 1 170 ? -32.50777 0.95263   -74.88667 1.000 28.13801 ? 170 GLN   B CD  1 
ATOM   3313 O  OE1 . GLN   B 1 170 ? -31.38569 1.45583   -74.94943 1.000 21.98680 ? 170 GLN   B OE1 1 
ATOM   3314 N  NE2 . GLN   B 1 170 ? -32.85578 -0.11188  -75.59976 1.000 28.35101 ? 170 GLN   B NE2 1 
ATOM   3315 N  N   . SER   B 1 171 ? -30.68857 0.30724   -71.53991 1.000 20.64456 ? 171 SER   B N   1 
ATOM   3316 C  CA  . SER   B 1 171 ? -29.72968 -0.77615  -71.73076 1.000 15.70580 ? 171 SER   B CA  1 
ATOM   3317 C  C   . SER   B 1 171 ? -29.98243 -1.90978  -70.74448 1.000 21.44708 ? 171 SER   B C   1 
ATOM   3318 O  O   . SER   B 1 171 ? -29.99240 -3.08651  -71.12486 1.000 18.82301 ? 171 SER   B O   1 
ATOM   3319 C  CB  . SER   B 1 171 ? -28.30311 -0.24422  -71.58939 1.000 19.02679 ? 171 SER   B CB  1 
ATOM   3320 O  OG  . SER   B 1 171 ? -28.08326 0.86640   -72.44235 1.000 24.68279 ? 171 SER   B OG  1 
ATOM   3321 N  N   . THR   B 1 172 ? -30.18300 -1.57216  -69.46751 1.000 21.03232 ? 172 THR   B N   1 
ATOM   3322 C  CA  . THR   B 1 172 ? -30.54746 -2.58353  -68.47965 1.000 22.24662 ? 172 THR   B CA  1 
ATOM   3323 C  C   . THR   B 1 172 ? -31.85312 -3.27137  -68.85932 1.000 17.80216 ? 172 THR   B C   1 
ATOM   3324 O  O   . THR   B 1 172 ? -31.99832 -4.48823  -68.69044 1.000 18.96208 ? 172 THR   B O   1 
ATOM   3325 C  CB  . THR   B 1 172 ? -30.66012 -1.94277  -67.09447 1.000 16.51007 ? 172 THR   B CB  1 
ATOM   3326 O  OG1 . THR   B 1 172 ? -29.36664 -1.50005  -66.66244 1.000 18.38234 ? 172 THR   B OG1 1 
ATOM   3327 C  CG2 . THR   B 1 172 ? -31.21786 -2.93242  -66.08294 1.000 16.26645 ? 172 THR   B CG2 1 
ATOM   3328 N  N   . HIS   B 1 173 ? -32.80905 -2.50244  -69.38648 1.000 18.91788 ? 173 HIS   B N   1 
ATOM   3329 C  CA  . HIS   B 1 173 ? -34.08101 -3.05899  -69.83685 1.000 22.35048 ? 173 HIS   B CA  1 
ATOM   3330 C  C   . HIS   B 1 173 ? -33.87863 -4.15290  -70.87920 1.000 29.14085 ? 173 HIS   B C   1 
ATOM   3331 O  O   . HIS   B 1 173 ? -34.61060 -5.14944  -70.89640 1.000 27.81345 ? 173 HIS   B O   1 
ATOM   3332 C  CB  . HIS   B 1 173 ? -34.95112 -1.92860  -70.38952 1.000 20.05458 ? 173 HIS   B CB  1 
ATOM   3333 C  CG  . HIS   B 1 173 ? -36.19133 -2.38992  -71.08901 1.000 31.80542 ? 173 HIS   B CG  1 
ATOM   3334 N  ND1 . HIS   B 1 173 ? -37.22739 -3.02079  -70.43498 1.000 30.58634 ? 173 HIS   B ND1 1 
ATOM   3335 C  CD2 . HIS   B 1 173 ? -36.57079 -2.28899  -72.38508 1.000 29.13477 ? 173 HIS   B CD2 1 
ATOM   3336 C  CE1 . HIS   B 1 173 ? -38.18721 -3.29801  -71.29952 1.000 32.61665 ? 173 HIS   B CE1 1 
ATOM   3337 N  NE2 . HIS   B 1 173 ? -37.81349 -2.86472  -72.49005 1.000 32.62208 ? 173 HIS   B NE2 1 
ATOM   3338 N  N   . VAL   B 1 174 ? -32.88199 -3.99005  -71.75090 1.000 26.73754 ? 174 VAL   B N   1 
ATOM   3339 C  CA  . VAL   B 1 174 ? -32.61985 -4.99579  -72.77615 1.000 24.37225 ? 174 VAL   B CA  1 
ATOM   3340 C  C   . VAL   B 1 174 ? -31.95593 -6.22294  -72.16372 1.000 25.38910 ? 174 VAL   B C   1 
ATOM   3341 O  O   . VAL   B 1 174 ? -32.40560 -7.35728  -72.36535 1.000 28.79115 ? 174 VAL   B O   1 
ATOM   3342 C  CB  . VAL   B 1 174 ? -31.76384 -4.39946  -73.90769 1.000 28.37763 ? 174 VAL   B CB  1 
ATOM   3343 C  CG1 . VAL   B 1 174 ? -31.23531 -5.50536  -74.80947 1.000 25.04686 ? 174 VAL   B CG1 1 
ATOM   3344 C  CG2 . VAL   B 1 174 ? -32.57230 -3.39435  -74.71090 1.000 26.88366 ? 174 VAL   B CG2 1 
ATOM   3345 N  N   . LEU   B 1 175 ? -30.87430 -6.01377  -71.40668 1.000 25.03500 ? 175 LEU   B N   1 
ATOM   3346 C  CA  . LEU   B 1 175 ? -30.13423 -7.12895  -70.82530 1.000 23.43421 ? 175 LEU   B CA  1 
ATOM   3347 C  C   . LEU   B 1 175 ? -30.97682 -7.94882  -69.85859 1.000 26.55374 ? 175 LEU   B C   1 
ATOM   3348 O  O   . LEU   B 1 175 ? -30.64616 -9.10851  -69.60058 1.000 24.37746 ? 175 LEU   B O   1 
ATOM   3349 C  CB  . LEU   B 1 175 ? -28.88307 -6.62082  -70.10757 1.000 23.00976 ? 175 LEU   B CB  1 
ATOM   3350 C  CG  . LEU   B 1 175 ? -27.89446 -5.77609  -70.91340 1.000 21.31036 ? 175 LEU   B CG  1 
ATOM   3351 C  CD1 . LEU   B 1 175 ? -26.82564 -5.20668  -69.99584 1.000 18.17647 ? 175 LEU   B CD1 1 
ATOM   3352 C  CD2 . LEU   B 1 175 ? -27.26491 -6.59015  -72.03474 1.000 19.86849 ? 175 LEU   B CD2 1 
ATOM   3353 N  N   . LEU   B 1 176 ? -32.04355 -7.37375  -69.30252 1.000 25.16821 ? 176 LEU   B N   1 
ATOM   3354 C  CA  . LEU   B 1 176 ? -32.94602 -8.16449  -68.47400 1.000 31.48934 ? 176 LEU   B CA  1 
ATOM   3355 C  C   . LEU   B 1 176 ? -33.72090 -9.17850  -69.30363 1.000 34.78948 ? 176 LEU   B C   1 
ATOM   3356 O  O   . LEU   B 1 176 ? -34.01377 -10.27827 -68.82100 1.000 32.26814 ? 176 LEU   B O   1 
ATOM   3357 C  CB  . LEU   B 1 176 ? -33.91378 -7.24842  -67.72529 1.000 26.73746 ? 176 LEU   B CB  1 
ATOM   3358 C  CG  . LEU   B 1 176 ? -33.38342 -6.51553  -66.49350 1.000 28.19762 ? 176 LEU   B CG  1 
ATOM   3359 C  CD1 . LEU   B 1 176 ? -34.32692 -5.39275  -66.10562 1.000 22.98000 ? 176 LEU   B CD1 1 
ATOM   3360 C  CD2 . LEU   B 1 176 ? -33.21014 -7.48617  -65.33779 1.000 28.92183 ? 176 LEU   B CD2 1 
ATOM   3361 N  N   . SER   B 1 177 ? -34.05131 -8.83378  -70.54649 1.000 32.54054 ? 177 SER   B N   1 
ATOM   3362 C  CA  . SER   B 1 177 ? -34.88188 -9.67039  -71.40056 1.000 36.06586 ? 177 SER   B CA  1 
ATOM   3363 C  C   . SER   B 1 177 ? -34.07528 -10.62085 -72.27434 1.000 31.48902 ? 177 SER   B C   1 
ATOM   3364 O  O   . SER   B 1 177 ? -34.62687 -11.18540 -73.22488 1.000 40.17432 ? 177 SER   B O   1 
ATOM   3365 C  CB  . SER   B 1 177 ? -35.78252 -8.79708  -72.27813 1.000 35.89958 ? 177 SER   B CB  1 
ATOM   3366 O  OG  . SER   B 1 177 ? -36.66724 -8.02290  -71.48936 1.000 40.77495 ? 177 SER   B OG  1 
ATOM   3367 N  N   . THR   B 1 178 ? -32.79408 -10.80531 -71.98254 1.000 29.04256 ? 178 THR   B N   1 
ATOM   3368 C  CA  . THR   B 1 178 ? -32.01763 -11.80633 -72.69588 1.000 37.66889 ? 178 THR   B CA  1 
ATOM   3369 C  C   . THR   B 1 178 ? -32.61923 -13.19001 -72.45914 1.000 44.87071 ? 178 THR   B C   1 
ATOM   3370 O  O   . THR   B 1 178 ? -33.02308 -13.50680 -71.33382 1.000 43.70425 ? 178 THR   B O   1 
ATOM   3371 C  CB  . THR   B 1 178 ? -30.55890 -11.79128 -72.24107 1.000 33.06834 ? 178 THR   B CB  1 
ATOM   3372 O  OG1 . THR   B 1 178 ? -29.89388 -12.93982 -72.75812 1.000 42.88717 ? 178 THR   B OG1 1 
ATOM   3373 C  CG2 . THR   B 1 178 ? -30.47497 -11.85824 -70.74701 1.000 43.97168 ? 178 THR   B CG2 1 
ATOM   3374 N  N   . PRO   B 1 179 ? -32.70807 -14.03092 -73.49199 1.000 45.03128 ? 179 PRO   B N   1 
ATOM   3375 C  CA  . PRO   B 1 179 ? -33.32768 -15.35605 -73.30735 1.000 39.60588 ? 179 PRO   B CA  1 
ATOM   3376 C  C   . PRO   B 1 179 ? -32.74679 -16.16779 -72.15788 1.000 42.83197 ? 179 PRO   B C   1 
ATOM   3377 O  O   . PRO   B 1 179 ? -33.49721 -16.87396 -71.47406 1.000 46.15845 ? 179 PRO   B O   1 
ATOM   3378 C  CB  . PRO   B 1 179 ? -33.08611 -16.02956 -74.66314 1.000 41.91112 ? 179 PRO   B CB  1 
ATOM   3379 C  CG  . PRO   B 1 179 ? -33.08204 -14.89229 -75.63212 1.000 35.86368 ? 179 PRO   B CG  1 
ATOM   3380 C  CD  . PRO   B 1 179 ? -32.43458 -13.73787 -74.91056 1.000 44.19514 ? 179 PRO   B CD  1 
ATOM   3381 N  N   . ALA   B 1 180 ? -31.43883 -16.07535 -71.90845 1.000 35.12982 ? 180 ALA   B N   1 
ATOM   3382 C  CA  . ALA   B 1 180 ? -30.82525 -16.86408 -70.84418 1.000 44.22531 ? 180 ALA   B CA  1 
ATOM   3383 C  C   . ALA   B 1 180 ? -31.13631 -16.33830 -69.44917 1.000 46.24133 ? 180 ALA   B C   1 
ATOM   3384 O  O   . ALA   B 1 180 ? -30.63764 -16.91005 -68.47343 1.000 48.20980 ? 180 ALA   B O   1 
ATOM   3385 C  CB  . ALA   B 1 180 ? -29.30918 -16.92883 -71.03639 1.000 34.16366 ? 180 ALA   B CB  1 
ATOM   3386 N  N   . LEU   B 1 181 ? -31.93343 -15.27604 -69.32584 1.000 42.70730 ? 181 LEU   B N   1 
ATOM   3387 C  CA  . LEU   B 1 181 ? -32.29029 -14.73438 -68.02240 1.000 49.49566 ? 181 LEU   B CA  1 
ATOM   3388 C  C   . LEU   B 1 181 ? -33.74892 -14.30970 -67.91987 1.000 58.20440 ? 181 LEU   B C   1 
ATOM   3389 O  O   . LEU   B 1 181 ? -34.17139 -13.89406 -66.83695 1.000 54.96735 ? 181 LEU   B O   1 
ATOM   3390 C  CB  . LEU   B 1 181 ? -31.40679 -13.51934 -67.67774 1.000 38.92650 ? 181 LEU   B CB  1 
ATOM   3391 C  CG  . LEU   B 1 181 ? -29.87622 -13.58336 -67.69196 1.000 37.82585 ? 181 LEU   B CG  1 
ATOM   3392 C  CD1 . LEU   B 1 181 ? -29.30575 -12.20228 -67.40085 1.000 33.60766 ? 181 LEU   B CD1 1 
ATOM   3393 C  CD2 . LEU   B 1 181 ? -29.34481 -14.58668 -66.69399 1.000 34.20976 ? 181 LEU   B CD2 1 
ATOM   3394 N  N   . GLU   B 1 182 ? -34.52849 -14.40456 -68.99309 1.000 63.86694 ? 182 GLU   B N   1 
ATOM   3395 C  CA  . GLU   B 1 182 ? -35.82118 -13.72355 -69.07497 1.000 63.16536 ? 182 GLU   B CA  1 
ATOM   3396 C  C   . GLU   B 1 182 ? -37.03542 -14.65086 -68.99652 1.000 73.01928 ? 182 GLU   B C   1 
ATOM   3397 O  O   . GLU   B 1 182 ? -37.24092 -15.49698 -69.86725 1.000 73.87327 ? 182 GLU   B O   1 
ATOM   3398 C  CB  . GLU   B 1 182 ? -35.87895 -12.91573 -70.37452 1.000 58.39408 ? 182 GLU   B CB  1 
ATOM   3399 C  CG  . GLU   B 1 182 ? -37.27017 -12.60750 -70.90670 1.000 58.51896 ? 182 GLU   B CG  1 
ATOM   3400 C  CD  . GLU   B 1 182 ? -37.91178 -11.40858 -70.24377 1.000 63.02109 ? 182 GLU   B CD  1 
ATOM   3401 O  OE1 . GLU   B 1 182 ? -37.85125 -11.29832 -69.00171 1.000 67.66806 ? 182 GLU   B OE1 1 
ATOM   3402 O  OE2 . GLU   B 1 182 ? -38.47499 -10.56749 -70.97436 1.000 60.11689 ? 182 GLU   B OE2 1 
ATOM   3403 N  N   . ALA   B 1 183 ? -37.81697 -14.51629 -67.92980 1.000 64.56959 ? 183 ALA   B N   1 
ATOM   3404 C  CA  . ALA   B 1 183 ? -37.41530 -13.73698 -66.76973 1.000 64.63395 ? 183 ALA   B CA  1 
ATOM   3405 C  C   . ALA   B 1 183 ? -36.94430 -14.72427 -65.72119 1.000 64.60222 ? 183 ALA   B C   1 
ATOM   3406 O  O   . ALA   B 1 183 ? -37.33843 -15.88830 -65.74258 1.000 58.85285 ? 183 ALA   B O   1 
ATOM   3407 C  CB  . ALA   B 1 183 ? -38.56043 -12.88728 -66.24623 1.000 61.96131 ? 183 ALA   B CB  1 
ATOM   3408 N  N   . VAL   B 1 184 ? -36.08982 -14.27353 -64.81116 1.000 55.20158 ? 184 VAL   B N   1 
ATOM   3409 C  CA  . VAL   B 1 184 ? -35.60536 -15.14594 -63.75101 1.000 52.05067 ? 184 VAL   B CA  1 
ATOM   3410 C  C   . VAL   B 1 184 ? -35.33269 -14.27455 -62.53236 1.000 42.97260 ? 184 VAL   B C   1 
ATOM   3411 O  O   . VAL   B 1 184 ? -34.58670 -14.65409 -61.62126 1.000 39.94378 ? 184 VAL   B O   1 
ATOM   3412 C  CB  . VAL   B 1 184 ? -34.36814 -15.94324 -64.21722 1.000 47.14720 ? 184 VAL   B CB  1 
ATOM   3413 C  CG1 . VAL   B 1 184 ? -33.07313 -15.12751 -64.09801 1.000 41.10039 ? 184 VAL   B CG1 1 
ATOM   3414 C  CG2 . VAL   B 1 184 ? -34.28023 -17.27070 -63.48670 1.000 53.68780 ? 184 VAL   B CG2 1 
ATOM   3415 N  N   . PHE   B 1 185 ? -35.99056 -13.11317 -62.48760 1.000 41.65636 ? 185 PHE   B N   1 
ATOM   3416 C  CA  . PHE   B 1 185 ? -35.63908 -12.06862 -61.53733 1.000 42.51097 ? 185 PHE   B CA  1 
ATOM   3417 C  C   . PHE   B 1 185 ? -36.82004 -11.48116 -60.77294 1.000 45.18159 ? 185 PHE   B C   1 
ATOM   3418 O  O   . PHE   B 1 185 ? -36.65361 -10.43557 -60.14712 1.000 45.51902 ? 185 PHE   B O   1 
ATOM   3419 C  CB  . PHE   B 1 185 ? -34.90855 -10.92570 -62.25228 1.000 32.36965 ? 185 PHE   B CB  1 
ATOM   3420 C  CG  . PHE   B 1 185 ? -33.45869 -11.19446 -62.50671 1.000 32.00278 ? 185 PHE   B CG  1 
ATOM   3421 C  CD1 . PHE   B 1 185 ? -32.58348 -11.38643 -61.45159 1.000 30.16567 ? 185 PHE   B CD1 1 
ATOM   3422 C  CD2 . PHE   B 1 185 ? -32.96479 -11.23383 -63.79925 1.000 25.94464 ? 185 PHE   B CD2 1 
ATOM   3423 C  CE1 . PHE   B 1 185 ? -31.24521 -11.62797 -61.68021 1.000 29.91942 ? 185 PHE   B CE1 1 
ATOM   3424 C  CE2 . PHE   B 1 185 ? -31.62673 -11.47273 -64.03514 1.000 25.01276 ? 185 PHE   B CE2 1 
ATOM   3425 C  CZ  . PHE   B 1 185 ? -30.76507 -11.67022 -62.97387 1.000 30.90972 ? 185 PHE   B CZ  1 
ATOM   3426 N  N   . THR   B 1 186 ? -38.00015 -12.10567 -60.79909 1.000 42.06989 ? 186 THR   B N   1 
ATOM   3427 C  CA  . THR   B 1 186 ? -39.20004 -11.54905 -60.16484 1.000 34.58921 ? 186 THR   B CA  1 
ATOM   3428 C  C   . THR   B 1 186 ? -39.52592 -10.13915 -60.66125 1.000 34.54152 ? 186 THR   B C   1 
ATOM   3429 O  O   . THR   B 1 186 ? -38.68289 -9.46132  -61.25322 1.000 37.03618 ? 186 THR   B O   1 
ATOM   3430 C  CB  . THR   B 1 186 ? -39.06686 -11.51914 -58.63320 1.000 42.33764 ? 186 THR   B CB  1 
ATOM   3431 O  OG1 . THR   B 1 186 ? -38.39729 -10.31624 -58.23308 1.000 38.01334 ? 186 THR   B OG1 1 
ATOM   3432 C  CG2 . THR   B 1 186 ? -38.29271 -12.72845 -58.11470 1.000 38.12723 ? 186 THR   B CG2 1 
ATOM   3433 N  N   . ASP   B 1 187 ? -40.75002 -9.67130  -60.42468 1.000 34.02992 ? 187 ASP   B N   1 
ATOM   3434 C  CA  . ASP   B 1 187 ? -41.06606 -8.29941  -60.80338 1.000 37.68406 ? 187 ASP   B CA  1 
ATOM   3435 C  C   . ASP   B 1 187 ? -40.38802 -7.28645  -59.89074 1.000 39.67665 ? 187 ASP   B C   1 
ATOM   3436 O  O   . ASP   B 1 187 ? -40.28035 -6.11094  -60.25764 1.000 34.52642 ? 187 ASP   B O   1 
ATOM   3437 C  CB  . ASP   B 1 187 ? -42.57828 -8.08500  -60.79696 1.000 43.05814 ? 187 ASP   B CB  1 
ATOM   3438 C  CG  . ASP   B 1 187 ? -43.33173 -9.26436  -61.37127 1.000 49.76365 ? 187 ASP   B CG  1 
ATOM   3439 O  OD1 . ASP   B 1 187 ? -42.77265 -9.95321  -62.25151 1.000 45.37417 ? 187 ASP   B OD1 1 
ATOM   3440 O  OD2 . ASP   B 1 187 ? -44.47948 -9.50348  -60.94020 1.000 52.25943 ? 187 ASP   B OD2 1 
ATOM   3441 N  N   . LEU   B 1 188 ? -39.91679 -7.72187  -58.72047 1.000 34.87022 ? 188 LEU   B N   1 
ATOM   3442 C  CA  . LEU   B 1 188 ? -39.30935 -6.80897  -57.75944 1.000 35.79648 ? 188 LEU   B CA  1 
ATOM   3443 C  C   . LEU   B 1 188 ? -37.84552 -6.53952  -58.09163 1.000 33.51554 ? 188 LEU   B C   1 
ATOM   3444 O  O   . LEU   B 1 188 ? -37.40720 -5.38406  -58.09324 1.000 28.84028 ? 188 LEU   B O   1 
ATOM   3445 C  CB  . LEU   B 1 188 ? -39.44690 -7.37617  -56.34557 1.000 37.12746 ? 188 LEU   B CB  1 
ATOM   3446 C  CG  . LEU   B 1 188 ? -39.15997 -6.40949  -55.19745 1.000 29.13009 ? 188 LEU   B CG  1 
ATOM   3447 C  CD1 . LEU   B 1 188 ? -40.12125 -5.23273  -55.24813 1.000 23.60842 ? 188 LEU   B CD1 1 
ATOM   3448 C  CD2 . LEU   B 1 188 ? -39.25523 -7.12761  -53.86213 1.000 29.50985 ? 188 LEU   B CD2 1 
ATOM   3449 N  N   . GLU   B 1 189 ? -37.06907 -7.59169  -58.37051 1.000 31.46515 ? 189 GLU   B N   1 
ATOM   3450 C  CA  . GLU   B 1 189 ? -35.67422 -7.37571  -58.74298 1.000 36.80229 ? 189 GLU   B CA  1 
ATOM   3451 C  C   . GLU   B 1 189 ? -35.56668 -6.72936  -60.12117 1.000 35.60000 ? 189 GLU   B C   1 
ATOM   3452 O  O   . GLU   B 1 189 ? -34.59917 -6.00844  -60.39031 1.000 30.17973 ? 189 GLU   B O   1 
ATOM   3453 C  CB  . GLU   B 1 189 ? -34.89320 -8.69502  -58.68332 1.000 31.15650 ? 189 GLU   B CB  1 
ATOM   3454 C  CG  . GLU   B 1 189 ? -35.25302 -9.57706  -57.47468 1.000 35.73342 ? 189 GLU   B CG  1 
ATOM   3455 C  CD  . GLU   B 1 189 ? -34.68270 -10.99529 -57.54154 1.000 45.33359 ? 189 GLU   B CD  1 
ATOM   3456 O  OE1 . GLU   B 1 189 ? -34.93008 -11.71071 -58.53087 1.000 40.52995 ? 189 GLU   B OE1 1 
ATOM   3457 O  OE2 . GLU   B 1 189 ? -33.99107 -11.40675 -56.58782 1.000 42.30182 ? 189 GLU   B OE2 1 
ATOM   3458 N  N   . ILE   B 1 190 ? -36.55341 -6.95328  -60.99477 1.000 28.02742 ? 190 ILE   B N   1 
ATOM   3459 C  CA  . ILE   B 1 190 ? -36.60398 -6.22704  -62.26261 1.000 31.27055 ? 190 ILE   B CA  1 
ATOM   3460 C  C   . ILE   B 1 190 ? -36.88203 -4.74982  -62.01359 1.000 32.11914 ? 190 ILE   B C   1 
ATOM   3461 O  O   . ILE   B 1 190 ? -36.25407 -3.87075  -62.61647 1.000 27.71746 ? 190 ILE   B O   1 
ATOM   3462 C  CB  . ILE   B 1 190 ? -37.65559 -6.84492  -63.20276 1.000 29.19359 ? 190 ILE   B CB  1 
ATOM   3463 C  CG1 . ILE   B 1 190 ? -37.21516 -8.23287  -63.66694 1.000 29.97848 ? 190 ILE   B CG1 1 
ATOM   3464 C  CG2 . ILE   B 1 190 ? -37.89983 -5.94028  -64.40545 1.000 31.50843 ? 190 ILE   B CG2 1 
ATOM   3465 C  CD1 . ILE   B 1 190 ? -38.29648 -9.00087  -64.40106 1.000 37.77368 ? 190 ILE   B CD1 1 
ATOM   3466 N  N   . LEU   B 1 191 ? -37.84003 -4.45600  -61.12984 1.000 25.64325 ? 191 LEU   B N   1 
ATOM   3467 C  CA  . LEU   B 1 191 ? -38.06088 -3.07737  -60.70811 1.000 28.45248 ? 191 LEU   B CA  1 
ATOM   3468 C  C   . LEU   B 1 191 ? -36.82079 -2.50357  -60.03999 1.000 26.51924 ? 191 LEU   B C   1 
ATOM   3469 O  O   . LEU   B 1 191 ? -36.56091 -1.29892  -60.13868 1.000 25.69806 ? 191 LEU   B O   1 
ATOM   3470 C  CB  . LEU   B 1 191 ? -39.25924 -3.00599  -59.75884 1.000 28.18847 ? 191 LEU   B CB  1 
ATOM   3471 C  CG  . LEU   B 1 191 ? -39.68266 -1.63623  -59.22198 1.000 29.21529 ? 191 LEU   B CG  1 
ATOM   3472 C  CD1 . LEU   B 1 191 ? -40.17540 -0.73951  -60.34597 1.000 22.84247 ? 191 LEU   B CD1 1 
ATOM   3473 C  CD2 . LEU   B 1 191 ? -40.75087 -1.78846  -58.14848 1.000 27.02879 ? 191 LEU   B CD2 1 
ATOM   3474 N  N   . ALA   B 1 192 ? -36.04073 -3.35317  -59.36816 1.000 25.23575 ? 192 ALA   B N   1 
ATOM   3475 C  CA  . ALA   B 1 192 ? -34.82621 -2.89257  -58.70558 1.000 27.70309 ? 192 ALA   B CA  1 
ATOM   3476 C  C   . ALA   B 1 192 ? -33.77717 -2.45678  -59.71707 1.000 24.06240 ? 192 ALA   B C   1 
ATOM   3477 O  O   . ALA   B 1 192 ? -33.25265 -1.34098  -59.63705 1.000 25.29735 ? 192 ALA   B O   1 
ATOM   3478 C  CB  . ALA   B 1 192 ? -34.27457 -3.99215  -57.79711 1.000 21.61293 ? 192 ALA   B CB  1 
ATOM   3479 N  N   . ALA   B 1 193 ? -33.45992 -3.32660  -60.67910 1.000 22.20547 ? 193 ALA   B N   1 
ATOM   3480 C  CA  . ALA   B 1 193 ? -32.41817 -3.01046  -61.65100 1.000 23.15216 ? 193 ALA   B CA  1 
ATOM   3481 C  C   . ALA   B 1 193 ? -32.77604 -1.77549  -62.46873 1.000 20.66503 ? 193 ALA   B C   1 
ATOM   3482 O  O   . ALA   B 1 193 ? -31.89886 -0.97473  -62.81360 1.000 16.32360 ? 193 ALA   B O   1 
ATOM   3483 C  CB  . ALA   B 1 193 ? -32.17467 -4.21070  -62.56570 1.000 26.22347 ? 193 ALA   B CB  1 
ATOM   3484 N  N   . ILE   B 1 194 ? -34.06059 -1.59679  -62.77650 1.000 17.27684 ? 194 ILE   B N   1 
ATOM   3485 C  CA  . ILE   B 1 194 ? -34.48590 -0.46100  -63.58819 1.000 21.14653 ? 194 ILE   B CA  1 
ATOM   3486 C  C   . ILE   B 1 194 ? -34.44464 0.82813   -62.77894 1.000 21.00264 ? 194 ILE   B C   1 
ATOM   3487 O  O   . ILE   B 1 194 ? -33.86318 1.82995   -63.21209 1.000 18.74058 ? 194 ILE   B O   1 
ATOM   3488 C  CB  . ILE   B 1 194 ? -35.88750 -0.71843  -64.16971 1.000 22.75701 ? 194 ILE   B CB  1 
ATOM   3489 C  CG1 . ILE   B 1 194 ? -35.83224 -1.84412  -65.20155 1.000 22.18393 ? 194 ILE   B CG1 1 
ATOM   3490 C  CG2 . ILE   B 1 194 ? -36.44984 0.54833   -64.79195 1.000 21.80528 ? 194 ILE   B CG2 1 
ATOM   3491 C  CD1 . ILE   B 1 194 ? -37.19113 -2.28338  -65.68763 1.000 25.32274 ? 194 ILE   B CD1 1 
ATOM   3492 N  N   . PHE   B 1 195 ? -35.06990 0.82504   -61.59797 1.000 16.34768 ? 195 PHE   B N   1 
ATOM   3493 C  CA  . PHE   B 1 195 ? -35.02986 2.00125   -60.73422 1.000 20.51901 ? 195 PHE   B CA  1 
ATOM   3494 C  C   . PHE   B 1 195 ? -33.59626 2.37121   -60.37588 1.000 15.54918 ? 195 PHE   B C   1 
ATOM   3495 O  O   . PHE   B 1 195 ? -33.22885 3.55209   -60.39801 1.000 14.56449 ? 195 PHE   B O   1 
ATOM   3496 C  CB  . PHE   B 1 195 ? -35.85529 1.75304   -59.47075 1.000 15.10378 ? 195 PHE   B CB  1 
ATOM   3497 C  CG  . PHE   B 1 195 ? -35.83274 2.89518   -58.49490 1.000 12.87283 ? 195 PHE   B CG  1 
ATOM   3498 C  CD1 . PHE   B 1 195 ? -36.62631 4.01291   -58.69488 1.000 17.15602 ? 195 PHE   B CD1 1 
ATOM   3499 C  CD2 . PHE   B 1 195 ? -35.02155 2.84771   -57.37315 1.000 16.13293 ? 195 PHE   B CD2 1 
ATOM   3500 C  CE1 . PHE   B 1 195 ? -36.60816 5.06411   -57.79684 1.000 19.87599 ? 195 PHE   B CE1 1 
ATOM   3501 C  CE2 . PHE   B 1 195 ? -34.99857 3.89481   -56.47207 1.000 14.73369 ? 195 PHE   B CE2 1 
ATOM   3502 C  CZ  . PHE   B 1 195 ? -35.79346 5.00474   -56.68441 1.000 16.74150 ? 195 PHE   B CZ  1 
ATOM   3503 N  N   . ALA   B 1 196 ? -32.76920 1.37193   -60.05246 1.000 17.43834 ? 196 ALA   B N   1 
ATOM   3504 C  CA  . ALA   B 1 196 ? -31.36518 1.63745   -59.75467 1.000 16.17433 ? 196 ALA   B CA  1 
ATOM   3505 C  C   . ALA   B 1 196 ? -30.65842 2.26374   -60.94862 1.000 17.18148 ? 196 ALA   B C   1 
ATOM   3506 O  O   . ALA   B 1 196 ? -29.89137 3.21995   -60.79103 1.000 14.94952 ? 196 ALA   B O   1 
ATOM   3507 C  CB  . ALA   B 1 196 ? -30.65965 0.34972   -59.33058 1.000 16.16926 ? 196 ALA   B CB  1 
ATOM   3508 N  N   . SER   B 1 197 ? -30.90951 1.74237   -62.15286 1.000 15.50063 ? 197 SER   B N   1 
ATOM   3509 C  CA  . SER   B 1 197 ? -30.32504 2.33540   -63.35169 1.000 15.15546 ? 197 SER   B CA  1 
ATOM   3510 C  C   . SER   B 1 197 ? -30.73405 3.79558   -63.49984 1.000 15.99472 ? 197 SER   B C   1 
ATOM   3511 O  O   . SER   B 1 197 ? -29.93246 4.63214   -63.93166 1.000 14.07536 ? 197 SER   B O   1 
ATOM   3512 C  CB  . SER   B 1 197 ? -30.74171 1.54013   -64.59004 1.000 15.13905 ? 197 SER   B CB  1 
ATOM   3513 O  OG  . SER   B 1 197 ? -30.20323 0.22997   -64.57066 1.000 14.28285 ? 197 SER   B OG  1 
ATOM   3514 N  N   . ALA   B 1 198 ? -31.97342 4.12498   -63.12794 1.000 15.24218 ? 198 ALA   B N   1 
ATOM   3515 C  CA  . ALA   B 1 198 ? -32.47732 5.47681   -63.35058 1.000 15.73634 ? 198 ALA   B CA  1 
ATOM   3516 C  C   . ALA   B 1 198 ? -31.81455 6.48742   -62.42506 1.000 15.86516 ? 198 ALA   B C   1 
ATOM   3517 O  O   . ALA   B 1 198 ? -31.56533 7.63067   -62.82439 1.000 15.46674 ? 198 ALA   B O   1 
ATOM   3518 C  CB  . ALA   B 1 198 ? -33.99484 5.50437   -63.17680 1.000 18.11445 ? 198 ALA   B CB  1 
ATOM   3519 N  N   . ILE   B 1 199 ? -31.51992 6.08807   -61.18670 1.000 14.01897 ? 199 ILE   B N   1 
ATOM   3520 C  CA  . ILE   B 1 199 ? -30.98039 7.00197   -60.18823 1.000 14.30191 ? 199 ILE   B CA  1 
ATOM   3521 C  C   . ILE   B 1 199 ? -29.47145 6.89232   -60.04488 1.000 11.67654 ? 199 ILE   B C   1 
ATOM   3522 O  O   . ILE   B 1 199 ? -28.88309 7.62255   -59.23598 1.000 13.29894 ? 199 ILE   B O   1 
ATOM   3523 C  CB  . ILE   B 1 199 ? -31.64067 6.76143   -58.81757 1.000 15.43156 ? 199 ILE   B CB  1 
ATOM   3524 C  CG1 . ILE   B 1 199 ? -31.17350 5.42082   -58.24710 1.000 12.67397 ? 199 ILE   B CG1 1 
ATOM   3525 C  CG2 . ILE   B 1 199 ? -33.15466 6.78654   -58.94116 1.000 15.12203 ? 199 ILE   B CG2 1 
ATOM   3526 C  CD1 . ILE   B 1 199 ? -31.51082 5.22583   -56.78648 1.000 14.97041 ? 199 ILE   B CD1 1 
ATOM   3527 N  N   . HIS   B 1 200 ? -28.82251 6.01469   -60.81508 1.000 12.10192 ? 200 HIS   B N   1 
ATOM   3528 C  CA  . HIS   B 1 200 ? -27.47442 5.56901   -60.47347 1.000 13.44423 ? 200 HIS   B CA  1 
ATOM   3529 C  C   . HIS   B 1 200 ? -26.41952 6.66221   -60.59954 1.000 12.35842 ? 200 HIS   B C   1 
ATOM   3530 O  O   . HIS   B 1 200 ? -25.31463 6.49050   -60.07591 1.000 9.81468  ? 200 HIS   B O   1 
ATOM   3531 C  CB  . HIS   B 1 200 ? -27.07726 4.37425   -61.34155 1.000 10.45212 ? 200 HIS   B CB  1 
ATOM   3532 C  CG  . HIS   B 1 200 ? -26.39387 4.75151   -62.61789 1.000 14.07568 ? 200 HIS   B CG  1 
ATOM   3533 N  ND1 . HIS   B 1 200 ? -27.08313 5.10416   -63.75835 1.000 12.27938 ? 200 HIS   B ND1 1 
ATOM   3534 C  CD2 . HIS   B 1 200 ? -25.07947 4.82666   -62.93396 1.000 10.33021 ? 200 HIS   B CD2 1 
ATOM   3535 C  CE1 . HIS   B 1 200 ? -26.22238 5.38195   -64.72126 1.000 14.28345 ? 200 HIS   B CE1 1 
ATOM   3536 N  NE2 . HIS   B 1 200 ? -25.00021 5.22127   -64.24701 1.000 12.63406 ? 200 HIS   B NE2 1 
ATOM   3537 N  N   . ASP   B 1 201 ? -26.71743 7.76960   -61.28459 1.000 12.04527 ? 201 ASP   B N   1 
ATOM   3538 C  CA  . ASP   B 1 201 ? -25.77671 8.88113   -61.38691 1.000 13.47982 ? 201 ASP   B CA  1 
ATOM   3539 C  C   . ASP   B 1 201 ? -26.42278 10.21688  -61.03610 1.000 12.95419 ? 201 ASP   B C   1 
ATOM   3540 O  O   . ASP   B 1 201 ? -25.89366 11.26613  -61.41449 1.000 11.56364 ? 201 ASP   B O   1 
ATOM   3541 C  CB  . ASP   B 1 201 ? -25.16535 8.96314   -62.78994 1.000 10.56155 ? 201 ASP   B CB  1 
ATOM   3542 C  CG  . ASP   B 1 201 ? -23.95234 8.06948   -62.95703 1.000 12.88444 ? 201 ASP   B CG  1 
ATOM   3543 O  OD1 . ASP   B 1 201 ? -23.28349 7.77121   -61.94484 1.000 8.87878  ? 201 ASP   B OD1 1 
ATOM   3544 O  OD2 . ASP   B 1 201 ? -23.65423 7.68663   -64.10774 1.000 10.57056 ? 201 ASP   B OD2 1 
ATOM   3545 N  N   . VAL   B 1 202 ? -27.54924 10.20741  -60.31830 1.000 10.98224 ? 202 VAL   B N   1 
ATOM   3546 C  CA  . VAL   B 1 202 ? -28.31990 11.43386  -60.15032 1.000 13.31010 ? 202 VAL   B CA  1 
ATOM   3547 C  C   . VAL   B 1 202 ? -27.52481 12.45246  -59.34163 1.000 13.46403 ? 202 VAL   B C   1 
ATOM   3548 O  O   . VAL   B 1 202 ? -26.80495 12.10763  -58.39420 1.000 14.48336 ? 202 VAL   B O   1 
ATOM   3549 C  CB  . VAL   B 1 202 ? -29.68737 11.13184  -59.51139 1.000 16.82612 ? 202 VAL   B CB  1 
ATOM   3550 C  CG1 . VAL   B 1 202 ? -29.53401 10.65943  -58.07530 1.000 12.18394 ? 202 VAL   B CG1 1 
ATOM   3551 C  CG2 . VAL   B 1 202 ? -30.59767 12.35209  -59.59009 1.000 14.87166 ? 202 VAL   B CG2 1 
ATOM   3552 N  N   . ASP   B 1 203 ? -27.63384 13.72077  -59.74740 1.000 12.71551 ? 203 ASP   B N   1 
ATOM   3553 C  CA  . ASP   B 1 203 ? -26.93081 14.84251  -59.12110 1.000 12.78920 ? 203 ASP   B CA  1 
ATOM   3554 C  C   . ASP   B 1 203 ? -25.41605 14.70351  -59.24770 1.000 12.84855 ? 203 ASP   B C   1 
ATOM   3555 O  O   . ASP   B 1 203 ? -24.66342 15.12998  -58.36846 1.000 12.69521 ? 203 ASP   B O   1 
ATOM   3556 C  CB  . ASP   B 1 203 ? -27.34524 15.01330  -57.65630 1.000 15.30327 ? 203 ASP   B CB  1 
ATOM   3557 C  CG  . ASP   B 1 203 ? -27.04409 16.39932  -57.12498 1.000 18.62187 ? 203 ASP   B CG  1 
ATOM   3558 O  OD1 . ASP   B 1 203 ? -27.15637 17.37233  -57.90119 1.000 18.94504 ? 203 ASP   B OD1 1 
ATOM   3559 O  OD2 . ASP   B 1 203 ? -26.69579 16.51482  -55.93238 1.000 15.39143 ? 203 ASP   B OD2 1 
ATOM   3560 N  N   . HIS   B 1 204 ? -24.96346 14.11500  -60.34675 1.000 13.62737 ? 204 HIS   B N   1 
ATOM   3561 C  CA  . HIS   B 1 204 ? -23.53337 13.98431  -60.59237 1.000 14.50914 ? 204 HIS   B CA  1 
ATOM   3562 C  C   . HIS   B 1 204 ? -22.94553 15.35415  -60.91506 1.000 14.30118 ? 204 HIS   B C   1 
ATOM   3563 O  O   . HIS   B 1 204 ? -23.44073 16.03616  -61.81981 1.000 13.69388 ? 204 HIS   B O   1 
ATOM   3564 C  CB  . HIS   B 1 204 ? -23.28327 13.01329  -61.74435 1.000 11.33047 ? 204 HIS   B CB  1 
ATOM   3565 C  CG  . HIS   B 1 204 ? -21.89937 12.44357  -61.76940 1.000 11.90339 ? 204 HIS   B CG  1 
ATOM   3566 N  ND1 . HIS   B 1 204 ? -20.77679 13.22139  -61.95174 1.000 13.03590 ? 204 HIS   B ND1 1 
ATOM   3567 C  CD2 . HIS   B 1 204 ? -21.45785 11.16933  -61.64702 1.000 11.15171 ? 204 HIS   B CD2 1 
ATOM   3568 C  CE1 . HIS   B 1 204 ? -19.70262 12.45277  -61.93270 1.000 13.39681 ? 204 HIS   B CE1 1 
ATOM   3569 N  NE2 . HIS   B 1 204 ? -20.08845 11.20273  -61.75053 1.000 12.13901 ? 204 HIS   B NE2 1 
ATOM   3570 N  N   . PRO   B 1 205 ? -21.90570 15.79670  -60.20350 1.000 14.50648 ? 205 PRO   B N   1 
ATOM   3571 C  CA  . PRO   B 1 205 ? -21.32868 17.11982  -60.46916 1.000 17.12058 ? 205 PRO   B CA  1 
ATOM   3572 C  C   . PRO   B 1 205 ? -20.35323 17.15755  -61.63439 1.000 19.62887 ? 205 PRO   B C   1 
ATOM   3573 O  O   . PRO   B 1 205 ? -19.81622 18.23063  -61.93076 1.000 15.55629 ? 205 PRO   B O   1 
ATOM   3574 C  CB  . PRO   B 1 205 ? -20.61476 17.44164  -59.15026 1.000 14.46124 ? 205 PRO   B CB  1 
ATOM   3575 C  CG  . PRO   B 1 205 ? -20.16453 16.10838  -58.66179 1.000 17.99497 ? 205 PRO   B CG  1 
ATOM   3576 C  CD  . PRO   B 1 205 ? -21.25212 15.13181  -59.06243 1.000 11.07705 ? 205 PRO   B CD  1 
ATOM   3577 N  N   . GLY   B 1 206 ? -20.10759 16.03198  -62.29950 1.000 17.90214 ? 206 GLY   B N   1 
ATOM   3578 C  CA  . GLY   B 1 206 ? -19.18661 15.99930  -63.41514 1.000 19.21404 ? 206 GLY   B CA  1 
ATOM   3579 C  C   . GLY   B 1 206 ? -17.73178 15.83017  -63.04532 1.000 16.56199 ? 206 GLY   B C   1 
ATOM   3580 O  O   . GLY   B 1 206 ? -16.86441 16.04979  -63.89852 1.000 17.69970 ? 206 GLY   B O   1 
ATOM   3581 N  N   . VAL   B 1 207 ? -17.43197 15.45839  -61.80030 1.000 12.68837 ? 207 VAL   B N   1 
ATOM   3582 C  CA  . VAL   B 1 207 ? -16.06714 15.20046  -61.36482 1.000 18.31919 ? 207 VAL   B CA  1 
ATOM   3583 C  C   . VAL   B 1 207 ? -16.02703 13.85297  -60.65713 1.000 15.46207 ? 207 VAL   B C   1 
ATOM   3584 O  O   . VAL   B 1 207 ? -17.03997 13.34723  -60.16888 1.000 16.28203 ? 207 VAL   B O   1 
ATOM   3585 C  CB  . VAL   B 1 207 ? -15.51402 16.31191  -60.44464 1.000 19.59492 ? 207 VAL   B CB  1 
ATOM   3586 C  CG1 . VAL   B 1 207 ? -15.37085 17.62059  -61.20940 1.000 19.02851 ? 207 VAL   B CG1 1 
ATOM   3587 C  CG2 . VAL   B 1 207 ? -16.40483 16.49368  -59.22662 1.000 16.41902 ? 207 VAL   B CG2 1 
ATOM   3588 N  N   . SER   B 1 208 ? -14.83040 13.27539  -60.60597 1.000 13.98077 ? 208 SER   B N   1 
ATOM   3589 C  CA  . SER   B 1 208 ? -14.65363 11.92576  -60.09764 1.000 14.64063 ? 208 SER   B CA  1 
ATOM   3590 C  C   . SER   B 1 208 ? -14.65760 11.91115  -58.57078 1.000 15.52716 ? 208 SER   B C   1 
ATOM   3591 O  O   . SER   B 1 208 ? -14.52933 12.94408  -57.90696 1.000 14.10547 ? 208 SER   B O   1 
ATOM   3592 C  CB  . SER   B 1 208 ? -13.35094 11.32412  -60.62447 1.000 16.69229 ? 208 SER   B CB  1 
ATOM   3593 O  OG  . SER   B 1 208 ? -12.22768 12.05897  -60.16696 1.000 19.37489 ? 208 SER   B OG  1 
ATOM   3594 N  N   . ASN   B 1 209 ? -14.81735 10.70574  -58.01565 1.000 15.32451 ? 209 ASN   B N   1 
ATOM   3595 C  CA  . ASN   B 1 209 ? -14.66254 10.52364  -56.57597 1.000 15.62403 ? 209 ASN   B CA  1 
ATOM   3596 C  C   . ASN   B 1 209 ? -13.30372 11.02247  -56.10390 1.000 16.78082 ? 209 ASN   B C   1 
ATOM   3597 O  O   . ASN   B 1 209 ? -13.20248 11.67849  -55.06077 1.000 18.07351 ? 209 ASN   B O   1 
ATOM   3598 C  CB  . ASN   B 1 209 ? -14.84005 9.04963   -56.20878 1.000 11.46233 ? 209 ASN   B CB  1 
ATOM   3599 C  CG  . ASN   B 1 209 ? -16.29446 8.63868   -56.11915 1.000 13.92230 ? 209 ASN   B CG  1 
ATOM   3600 O  OD1 . ASN   B 1 209 ? -17.13817 9.40266   -55.65492 1.000 15.11173 ? 209 ASN   B OD1 1 
ATOM   3601 N  ND2 . ASN   B 1 209 ? -16.59510 7.42308   -56.56221 1.000 12.46533 ? 209 ASN   B ND2 1 
ATOM   3602 N  N   . GLN   B 1 210 ? -12.24705 10.72671  -56.86553 1.000 20.36401 ? 210 GLN   B N   1 
ATOM   3603 C  CA  . GLN   B 1 210 ? -10.90439 11.12703  -56.45746 1.000 17.32742 ? 210 GLN   B CA  1 
ATOM   3604 C  C   . GLN   B 1 210 ? -10.76644 12.64353  -56.41571 1.000 21.49195 ? 210 GLN   B C   1 
ATOM   3605 O  O   . GLN   B 1 210 ? -10.14868 13.19166  -55.49470 1.000 23.91067 ? 210 GLN   B O   1 
ATOM   3606 C  CB  . GLN   B 1 210 ? -9.86553  10.51782  -57.39819 1.000 20.53385 ? 210 GLN   B CB  1 
ATOM   3607 C  CG  . GLN   B 1 210 ? -8.45668  10.52421  -56.83297 1.000 27.44362 ? 210 GLN   B CG  1 
ATOM   3608 C  CD  . GLN   B 1 210 ? -8.37398  9.81542   -55.49490 1.000 29.17069 ? 210 GLN   B CD  1 
ATOM   3609 O  OE1 . GLN   B 1 210 ? -8.44153  8.58860   -55.42636 1.000 27.18336 ? 210 GLN   B OE1 1 
ATOM   3610 N  NE2 . GLN   B 1 210 ? -8.24120  10.58729  -54.42062 1.000 22.71567 ? 210 GLN   B NE2 1 
ATOM   3611 N  N   . PHE   B 1 211 ? -11.32949 13.33809  -57.40817 1.000 19.73836 ? 211 PHE   B N   1 
ATOM   3612 C  CA  . PHE   B 1 211 ? -11.34419 14.79754  -57.37632 1.000 17.88124 ? 211 PHE   B CA  1 
ATOM   3613 C  C   . PHE   B 1 211 ? -12.07982 15.30264  -56.14206 1.000 21.97353 ? 211 PHE   B C   1 
ATOM   3614 O  O   . PHE   B 1 211 ? -11.60206 16.20572  -55.44553 1.000 22.84571 ? 211 PHE   B O   1 
ATOM   3615 C  CB  . PHE   B 1 211 ? -11.98698 15.34710  -58.65265 1.000 15.86126 ? 211 PHE   B CB  1 
ATOM   3616 C  CG  . PHE   B 1 211 ? -12.09213 16.85227  -58.68720 1.000 21.28365 ? 211 PHE   B CG  1 
ATOM   3617 C  CD1 . PHE   B 1 211 ? -13.19878 17.50037  -58.15809 1.000 21.39308 ? 211 PHE   B CD1 1 
ATOM   3618 C  CD2 . PHE   B 1 211 ? -11.08731 17.61798  -59.25677 1.000 21.02569 ? 211 PHE   B CD2 1 
ATOM   3619 C  CE1 . PHE   B 1 211 ? -13.29983 18.87962  -58.19091 1.000 28.01940 ? 211 PHE   B CE1 1 
ATOM   3620 C  CE2 . PHE   B 1 211 ? -11.18253 19.00030  -59.29268 1.000 24.35632 ? 211 PHE   B CE2 1 
ATOM   3621 C  CZ  . PHE   B 1 211 ? -12.29086 19.63076  -58.75906 1.000 28.06483 ? 211 PHE   B CZ  1 
ATOM   3622 N  N   . LEU   B 1 212 ? -13.25247 14.72846  -55.85892 1.000 20.11550 ? 212 LEU   B N   1 
ATOM   3623 C  CA  . LEU   B 1 212 ? -14.00358 15.11737  -54.66958 1.000 21.76687 ? 212 LEU   B CA  1 
ATOM   3624 C  C   . LEU   B 1 212 ? -13.19704 14.86898  -53.40208 1.000 21.40942 ? 212 LEU   B C   1 
ATOM   3625 O  O   . LEU   B 1 212 ? -13.22458 15.68119  -52.47007 1.000 20.65816 ? 212 LEU   B O   1 
ATOM   3626 C  CB  . LEU   B 1 212 ? -15.32839 14.35767  -54.61664 1.000 16.98163 ? 212 LEU   B CB  1 
ATOM   3627 C  CG  . LEU   B 1 212 ? -16.39202 14.75961  -55.63642 1.000 15.21228 ? 212 LEU   B CG  1 
ATOM   3628 C  CD1 . LEU   B 1 212 ? -17.56541 13.80145  -55.56842 1.000 16.85570 ? 212 LEU   B CD1 1 
ATOM   3629 C  CD2 . LEU   B 1 212 ? -16.85224 16.18724  -55.39014 1.000 16.91704 ? 212 LEU   B CD2 1 
ATOM   3630 N  N   . ILE   B 1 213 ? -12.47342 13.74911  -53.34932 1.000 19.49324 ? 213 ILE   B N   1 
ATOM   3631 C  CA  . ILE   B 1 213 ? -11.62960 13.45860  -52.19331 1.000 20.65364 ? 213 ILE   B CA  1 
ATOM   3632 C  C   . ILE   B 1 213 ? -10.50862 14.48488  -52.08563 1.000 26.89489 ? 213 ILE   B C   1 
ATOM   3633 O  O   . ILE   B 1 213 ? -10.24590 15.03549  -51.00963 1.000 25.44911 ? 213 ILE   B O   1 
ATOM   3634 C  CB  . ILE   B 1 213 ? -11.07495 12.02517  -52.28193 1.000 19.70272 ? 213 ILE   B CB  1 
ATOM   3635 C  CG1 . ILE   B 1 213 ? -12.20137 11.00176  -52.12072 1.000 14.52416 ? 213 ILE   B CG1 1 
ATOM   3636 C  CG2 . ILE   B 1 213 ? -9.99191  11.80454  -51.23738 1.000 19.19538 ? 213 ILE   B CG2 1 
ATOM   3637 C  CD1 . ILE   B 1 213 ? -11.79008 9.58085   -52.45054 1.000 13.42896 ? 213 ILE   B CD1 1 
ATOM   3638 N  N   . ASN   B 1 214 ? -9.84381  14.77140  -53.20831 1.000 26.08183 ? 214 ASN   B N   1 
ATOM   3639 C  CA  . ASN   B 1 214 ? -8.67652  15.64625  -53.19385 1.000 27.98288 ? 214 ASN   B CA  1 
ATOM   3640 C  C   . ASN   B 1 214 ? -9.02525  17.10277  -52.91714 1.000 28.36629 ? 214 ASN   B C   1 
ATOM   3641 O  O   . ASN   B 1 214 ? -8.17014  17.84417  -52.42181 1.000 33.66546 ? 214 ASN   B O   1 
ATOM   3642 C  CB  . ASN   B 1 214 ? -7.92772  15.54909  -54.52321 1.000 24.36608 ? 214 ASN   B CB  1 
ATOM   3643 C  CG  . ASN   B 1 214 ? -7.32687  14.17925  -54.75746 1.000 26.34735 ? 214 ASN   B CG  1 
ATOM   3644 O  OD1 . ASN   B 1 214 ? -7.15346  13.39518  -53.82468 1.000 28.80160 ? 214 ASN   B OD1 1 
ATOM   3645 N  ND2 . ASN   B 1 214 ? -6.99631  13.88666  -56.00987 1.000 26.87703 ? 214 ASN   B ND2 1 
ATOM   3646 N  N   . THR   B 1 215 ? -10.24243 17.53590  -53.23286 1.000 24.76250 ? 215 THR   B N   1 
ATOM   3647 C  CA  . THR   B 1 215 ? -10.64648 18.91711  -53.01131 1.000 24.27189 ? 215 THR   B CA  1 
ATOM   3648 C  C   . THR   B 1 215 ? -11.30645 19.12435  -51.65595 1.000 23.98760 ? 215 THR   B C   1 
ATOM   3649 O  O   . THR   B 1 215 ? -11.83668 20.21134  -51.40019 1.000 23.29639 ? 215 THR   B O   1 
ATOM   3650 C  CB  . THR   B 1 215 ? -11.58910 19.37990  -54.12611 1.000 29.28285 ? 215 THR   B CB  1 
ATOM   3651 O  OG1 . THR   B 1 215 ? -12.68695 18.46571  -54.24290 1.000 21.23012 ? 215 THR   B OG1 1 
ATOM   3652 C  CG2 . THR   B 1 215 ? -10.84581 19.44489  -55.44963 1.000 28.85427 ? 215 THR   B CG2 1 
ATOM   3653 N  N   . ASN   B 1 216 ? -11.27015 18.11301  -50.78683 1.000 25.65463 ? 216 ASN   B N   1 
ATOM   3654 C  CA  . ASN   B 1 216 ? -11.92792 18.15229  -49.48199 1.000 30.00676 ? 216 ASN   B CA  1 
ATOM   3655 C  C   . ASN   B 1 216 ? -13.37188 18.62324  -49.62516 1.000 24.93963 ? 216 ASN   B C   1 
ATOM   3656 O  O   . ASN   B 1 216 ? -13.84187 19.52005  -48.92098 1.000 25.67899 ? 216 ASN   B O   1 
ATOM   3657 C  CB  . ASN   B 1 216 ? -11.14610 19.02382  -48.49865 1.000 32.91741 ? 216 ASN   B CB  1 
ATOM   3658 C  CG  . ASN   B 1 216 ? -9.69870  18.58510  -48.35798 1.000 29.95251 ? 216 ASN   B CG  1 
ATOM   3659 O  OD1 . ASN   B 1 216 ? -9.41361  17.48813  -47.87560 1.000 40.05976 ? 216 ASN   B OD1 1 
ATOM   3660 N  ND2 . ASN   B 1 216 ? -8.77661  19.44394  -48.77674 1.000 34.95137 ? 216 ASN   B ND2 1 
ATOM   3661 N  N   . SER   B 1 217 ? -14.06945 18.00981  -50.57619 1.000 24.27271 ? 217 SER   B N   1 
ATOM   3662 C  CA  . SER   B 1 217 ? -15.45048 18.35367  -50.85922 1.000 21.91557 ? 217 SER   B CA  1 
ATOM   3663 C  C   . SER   B 1 217 ? -16.34290 18.00647  -49.67406 1.000 19.38854 ? 217 SER   B C   1 
ATOM   3664 O  O   . SER   B 1 217 ? -16.00518 17.17775  -48.82395 1.000 17.40012 ? 217 SER   B O   1 
ATOM   3665 C  CB  . SER   B 1 217 ? -15.93695 17.61823  -52.10851 1.000 19.47158 ? 217 SER   B CB  1 
ATOM   3666 O  OG  . SER   B 1 217 ? -15.78156 16.21525  -51.96441 1.000 18.80610 ? 217 SER   B OG  1 
ATOM   3667 N  N   . GLU   B 1 218 ? -17.50023 18.66543  -49.62259 1.000 17.01462 ? 218 GLU   B N   1 
ATOM   3668 C  CA  . GLU   B 1 218 ? -18.49975 18.30445  -48.62612 1.000 20.02209 ? 218 GLU   B CA  1 
ATOM   3669 C  C   . GLU   B 1 218 ? -18.99336 16.88119  -48.84850 1.000 18.48873 ? 218 GLU   B C   1 
ATOM   3670 O  O   . GLU   B 1 218 ? -19.31538 16.16869  -47.89056 1.000 17.53877 ? 218 GLU   B O   1 
ATOM   3671 C  CB  . GLU   B 1 218 ? -19.66089 19.29809  -48.67173 1.000 22.61145 ? 218 GLU   B CB  1 
ATOM   3672 C  CG  . GLU   B 1 218 ? -20.31774 19.57473  -47.32692 1.000 37.28378 ? 218 GLU   B CG  1 
ATOM   3673 C  CD  . GLU   B 1 218 ? -19.36484 20.16775  -46.29903 1.000 40.86939 ? 218 GLU   B CD  1 
ATOM   3674 O  OE1 . GLU   B 1 218 ? -18.29902 20.69549  -46.68465 1.000 43.26401 ? 218 GLU   B OE1 1 
ATOM   3675 O  OE2 . GLU   B 1 218 ? -19.69314 20.11670  -45.09559 1.000 45.75070 ? 218 GLU   B OE2 1 
ATOM   3676 N  N   . LEU   B 1 219 ? -19.04284 16.44556  -50.10943 1.000 13.70475 ? 219 LEU   B N   1 
ATOM   3677 C  CA  . LEU   B 1 219 ? -19.48126 15.08758  -50.41432 1.000 15.68114 ? 219 LEU   B CA  1 
ATOM   3678 C  C   . LEU   B 1 219 ? -18.50856 14.05487  -49.85706 1.000 13.01605 ? 219 LEU   B C   1 
ATOM   3679 O  O   . LEU   B 1 219 ? -18.92060 13.07756  -49.22148 1.000 12.06510 ? 219 LEU   B O   1 
ATOM   3680 C  CB  . LEU   B 1 219 ? -19.64805 14.91924  -51.92523 1.000 14.68691 ? 219 LEU   B CB  1 
ATOM   3681 C  CG  . LEU   B 1 219 ? -20.99873 15.35335  -52.49558 1.000 16.31472 ? 219 LEU   B CG  1 
ATOM   3682 C  CD1 . LEU   B 1 219 ? -21.08881 15.03764  -53.98188 1.000 19.64469 ? 219 LEU   B CD1 1 
ATOM   3683 C  CD2 . LEU   B 1 219 ? -22.12083 14.67192  -51.72758 1.000 16.34988 ? 219 LEU   B CD2 1 
ATOM   3684 N  N   . ALA   B 1 220 ? -17.20808 14.25162  -50.09081 1.000 12.94320 ? 220 ALA   B N   1 
ATOM   3685 C  CA  . ALA   B 1 220 ? -16.21670 13.32855  -49.54798 1.000 11.42187 ? 220 ALA   B CA  1 
ATOM   3686 C  C   . ALA   B 1 220 ? -16.18611 13.37317  -48.02646 1.000 15.57398 ? 220 ALA   B C   1 
ATOM   3687 O  O   . ALA   B 1 220 ? -15.94096 12.34786  -47.38070 1.000 13.89829 ? 220 ALA   B O   1 
ATOM   3688 C  CB  . ALA   B 1 220 ? -14.83380 13.64447  -50.11692 1.000 14.84435 ? 220 ALA   B CB  1 
ATOM   3689 N  N   . LEU   B 1 221 ? -16.43045 14.54760  -47.44202 1.000 14.29537 ? 221 LEU   B N   1 
ATOM   3690 C  CA  . LEU   B 1 221 ? -16.50416 14.66362  -45.98986 1.000 14.56396 ? 221 LEU   B CA  1 
ATOM   3691 C  C   . LEU   B 1 221 ? -17.71393 13.91619  -45.44347 1.000 15.19248 ? 221 LEU   B C   1 
ATOM   3692 O  O   . LEU   B 1 221 ? -17.63161 13.26874  -44.39284 1.000 12.17305 ? 221 LEU   B O   1 
ATOM   3693 C  CB  . LEU   B 1 221 ? -16.55429 16.14214  -45.60239 1.000 15.75384 ? 221 LEU   B CB  1 
ATOM   3694 C  CG  . LEU   B 1 221 ? -16.36106 16.60664  -44.15979 1.000 29.97646 ? 221 LEU   B CG  1 
ATOM   3695 C  CD1 . LEU   B 1 221 ? -15.00985 16.17549  -43.62247 1.000 21.53892 ? 221 LEU   B CD1 1 
ATOM   3696 C  CD2 . LEU   B 1 221 ? -16.49090 18.11861  -44.10983 1.000 27.69346 ? 221 LEU   B CD2 1 
ATOM   3697 N  N   . MET   B 1 222 ? -18.84361 13.98901  -46.15113 1.000 13.43783 ? 222 MET   B N   1 
ATOM   3698 C  CA  . MET   B 1 222 ? -20.04479 13.28656  -45.71370 1.000 14.72999 ? 222 MET   B CA  1 
ATOM   3699 C  C   . MET   B 1 222 ? -19.84976 11.77609  -45.74631 1.000 13.22407 ? 222 MET   B C   1 
ATOM   3700 O  O   . MET   B 1 222 ? -20.22822 11.07353  -44.80206 1.000 10.73870 ? 222 MET   B O   1 
ATOM   3701 C  CB  . MET   B 1 222 ? -21.23091 13.68529  -46.59277 1.000 16.09796 ? 222 MET   B CB  1 
ATOM   3702 C  CG  . MET   B 1 222 ? -22.54714 13.02116  -46.21435 1.000 17.33579 ? 222 MET   B CG  1 
ATOM   3703 S  SD  . MET   B 1 222 ? -23.27247 13.70352  -44.71361 1.000 23.13570 ? 222 MET   B SD  1 
ATOM   3704 C  CE  . MET   B 1 222 ? -23.74265 15.33212  -45.29239 1.000 20.79448 ? 222 MET   B CE  1 
ATOM   3705 N  N   . TYR   B 1 223 ? -19.24840 11.25831  -46.81652 1.000 13.40752 ? 223 TYR   B N   1 
ATOM   3706 C  CA  . TYR   B 1 223 ? -19.23968 9.82568   -47.08065 1.000 11.90529 ? 223 TYR   B CA  1 
ATOM   3707 C  C   . TYR   B 1 223 ? -17.88729 9.16848   -46.84106 1.000 14.03955 ? 223 TYR   B C   1 
ATOM   3708 O  O   . TYR   B 1 223 ? -17.68374 8.02799   -47.27215 1.000 9.30498  ? 223 TYR   B O   1 
ATOM   3709 C  CB  . TYR   B 1 223 ? -19.71504 9.56279   -48.50818 1.000 10.82632 ? 223 TYR   B CB  1 
ATOM   3710 C  CG  . TYR   B 1 223 ? -21.18683 9.83866   -48.66527 1.000 12.46790 ? 223 TYR   B CG  1 
ATOM   3711 C  CD1 . TYR   B 1 223 ? -22.12227 9.06264   -47.99813 1.000 11.85509 ? 223 TYR   B CD1 1 
ATOM   3712 C  CD2 . TYR   B 1 223 ? -21.64242 10.88269  -49.45804 1.000 12.21294 ? 223 TYR   B CD2 1 
ATOM   3713 C  CE1 . TYR   B 1 223 ? -23.46837 9.30716   -48.12348 1.000 15.24556 ? 223 TYR   B CE1 1 
ATOM   3714 C  CE2 . TYR   B 1 223 ? -22.99326 11.13532  -49.59130 1.000 12.87507 ? 223 TYR   B CE2 1 
ATOM   3715 C  CZ  . TYR   B 1 223 ? -23.90091 10.34340  -48.92105 1.000 11.47650 ? 223 TYR   B CZ  1 
ATOM   3716 O  OH  . TYR   B 1 223 ? -25.24794 10.58611  -49.04579 1.000 10.49796 ? 223 TYR   B OH  1 
ATOM   3717 N  N   . ASN   B 1 224 ? -16.96287 9.85642   -46.16868 1.000 11.71598 ? 224 ASN   B N   1 
ATOM   3718 C  CA  . ASN   B 1 224 ? -15.72267 9.24917   -45.67958 1.000 11.69292 ? 224 ASN   B CA  1 
ATOM   3719 C  C   . ASN   B 1 224 ? -14.93141 8.58164   -46.80474 1.000 11.33618 ? 224 ASN   B C   1 
ATOM   3720 O  O   . ASN   B 1 224 ? -14.38253 7.48978   -46.63914 1.000 11.46256 ? 224 ASN   B O   1 
ATOM   3721 C  CB  . ASN   B 1 224 ? -16.01662 8.25789   -44.55099 1.000 11.07513 ? 224 ASN   B CB  1 
ATOM   3722 C  CG  . ASN   B 1 224 ? -16.69035 8.91792   -43.36054 1.000 11.44454 ? 224 ASN   B CG  1 
ATOM   3723 O  OD1 . ASN   B 1 224 ? -16.15244 9.85588   -42.77250 1.000 13.73455 ? 224 ASN   B OD1 1 
ATOM   3724 N  ND2 . ASN   B 1 224 ? -17.88468 8.44636   -43.01604 1.000 7.92207  ? 224 ASN   B ND2 1 
ATOM   3725 N  N   . ASP   B 1 225 ? -14.89772 9.23788   -47.96642 1.000 9.79368  ? 225 ASP   B N   1 
ATOM   3726 C  CA  . ASP   B 1 225 ? -14.06291 8.90100   -49.11954 1.000 14.11009 ? 225 ASP   B CA  1 
ATOM   3727 C  C   . ASP   B 1 225 ? -14.41802 7.57405   -49.78254 1.000 13.63188 ? 225 ASP   B C   1 
ATOM   3728 O  O   . ASP   B 1 225 ? -13.70572 7.14794   -50.70132 1.000 16.13593 ? 225 ASP   B O   1 
ATOM   3729 C  CB  . ASP   B 1 225 ? -12.57330 8.88713   -48.75400 1.000 11.47764 ? 225 ASP   B CB  1 
ATOM   3730 C  CG  . ASP   B 1 225 ? -12.08387 10.23046  -48.25530 1.000 16.39124 ? 225 ASP   B CG  1 
ATOM   3731 O  OD1 . ASP   B 1 225 ? -12.75152 11.24969  -48.53180 1.000 16.82767 ? 225 ASP   B OD1 1 
ATOM   3732 O  OD2 . ASP   B 1 225 ? -11.02721 10.26914  -47.59135 1.000 14.95706 ? 225 ASP   B OD2 1 
ATOM   3733 N  N   . SER   B 1 226 ? -15.49535 6.91182   -49.36660 1.000 12.63570 ? 226 SER   B N   1 
ATOM   3734 C  CA  . SER   B 1 226 ? -15.85719 5.59380   -49.88136 1.000 13.25497 ? 226 SER   B CA  1 
ATOM   3735 C  C   . SER   B 1 226 ? -17.09324 5.70275   -50.76461 1.000 14.01368 ? 226 SER   B C   1 
ATOM   3736 O  O   . SER   B 1 226 ? -18.17709 6.03905   -50.27394 1.000 9.80726  ? 226 SER   B O   1 
ATOM   3737 C  CB  . SER   B 1 226 ? -16.11547 4.61064   -48.73962 1.000 11.60768 ? 226 SER   B CB  1 
ATOM   3738 O  OG  . SER   B 1 226 ? -15.20592 4.81128   -47.67216 1.000 31.10102 ? 226 SER   B OG  1 
ATOM   3739 N  N   . SER   B 1 227 ? -16.93129 5.38144   -52.04986 1.000 10.61805 ? 227 SER   B N   1 
ATOM   3740 C  CA  . SER   B 1 227 ? -18.00875 5.44241   -53.04081 1.000 13.21383 ? 227 SER   B CA  1 
ATOM   3741 C  C   . SER   B 1 227 ? -18.83542 6.71156   -52.86293 1.000 10.76400 ? 227 SER   B C   1 
ATOM   3742 O  O   . SER   B 1 227 ? -20.06123 6.68129   -52.73128 1.000 13.32051 ? 227 SER   B O   1 
ATOM   3743 C  CB  . SER   B 1 227 ? -18.89062 4.19436   -52.97400 1.000 12.27921 ? 227 SER   B CB  1 
ATOM   3744 O  OG  . SER   B 1 227 ? -18.19304 3.04492   -53.42711 1.000 12.52642 ? 227 SER   B OG  1 
ATOM   3745 N  N   . VAL   B 1 228 ? -18.12901 7.84385   -52.84888 1.000 9.80923  ? 228 VAL   B N   1 
ATOM   3746 C  CA  . VAL   B 1 228 ? -18.73879 9.11657   -52.46962 1.000 10.82988 ? 228 VAL   B CA  1 
ATOM   3747 C  C   . VAL   B 1 228 ? -19.88185 9.46851   -53.41264 1.000 11.82242 ? 228 VAL   B C   1 
ATOM   3748 O  O   . VAL   B 1 228 ? -20.99748 9.77805   -52.97699 1.000 11.27346 ? 228 VAL   B O   1 
ATOM   3749 C  CB  . VAL   B 1 228 ? -17.67357 10.22640  -52.43667 1.000 12.47533 ? 228 VAL   B CB  1 
ATOM   3750 C  CG1 . VAL   B 1 228 ? -18.32527 11.57506  -52.22250 1.000 11.28959 ? 228 VAL   B CG1 1 
ATOM   3751 C  CG2 . VAL   B 1 228 ? -16.65591 9.94526   -51.34769 1.000 8.47559  ? 228 VAL   B CG2 1 
ATOM   3752 N  N   . LEU   B 1 229 ? -19.61825 9.43318   -54.71981 1.000 11.03857 ? 229 LEU   B N   1 
ATOM   3753 C  CA  . LEU   B 1 229 ? -20.65878 9.73839   -55.69651 1.000 11.75686 ? 229 LEU   B CA  1 
ATOM   3754 C  C   . LEU   B 1 229 ? -21.81295 8.74987   -55.59713 1.000 12.79307 ? 229 LEU   B C   1 
ATOM   3755 O  O   . LEU   B 1 229 ? -22.98449 9.14420   -55.55622 1.000 10.73677 ? 229 LEU   B O   1 
ATOM   3756 C  CB  . LEU   B 1 229 ? -20.07014 9.72500   -57.10695 1.000 12.62353 ? 229 LEU   B CB  1 
ATOM   3757 C  CG  . LEU   B 1 229 ? -19.16189 10.88227  -57.51339 1.000 14.62291 ? 229 LEU   B CG  1 
ATOM   3758 C  CD1 . LEU   B 1 229 ? -18.42016 10.53687  -58.79177 1.000 13.35246 ? 229 LEU   B CD1 1 
ATOM   3759 C  CD2 . LEU   B 1 229 ? -19.98101 12.13825  -57.69382 1.000 13.95520 ? 229 LEU   B CD2 1 
ATOM   3760 N  N   . GLU   B 1 230 ? -21.49405 7.45443   -55.54539 1.000 9.26150  ? 230 GLU   B N   1 
ATOM   3761 C  CA  . GLU   B 1 230 ? -22.52481 6.42441   -55.62301 1.000 13.96800 ? 230 GLU   B CA  1 
ATOM   3762 C  C   . GLU   B 1 230 ? -23.42788 6.44153   -54.39532 1.000 11.92546 ? 230 GLU   B C   1 
ATOM   3763 O  O   . GLU   B 1 230 ? -24.64228 6.23955   -54.51238 1.000 9.91512  ? 230 GLU   B O   1 
ATOM   3764 C  CB  . GLU   B 1 230 ? -21.87596 5.05191   -55.80900 1.000 10.34427 ? 230 GLU   B CB  1 
ATOM   3765 C  CG  . GLU   B 1 230 ? -21.20469 4.85971   -57.16976 1.000 10.74907 ? 230 GLU   B CG  1 
ATOM   3766 C  CD  . GLU   B 1 230 ? -19.89189 5.61826   -57.30583 1.000 12.65173 ? 230 GLU   B CD  1 
ATOM   3767 O  OE1 . GLU   B 1 230 ? -19.29754 5.98334   -56.26952 1.000 12.08722 ? 230 GLU   B OE1 1 
ATOM   3768 O  OE2 . GLU   B 1 230 ? -19.45627 5.85419   -58.45267 1.000 14.18576 ? 230 GLU   B OE2 1 
ATOM   3769 N  N   . ASN   B 1 231 ? -22.85815 6.68005   -53.21057 1.000 9.85453  ? 231 ASN   B N   1 
ATOM   3770 C  CA  . ASN   B 1 231 ? -23.68867 6.87221   -52.02546 1.000 12.18720 ? 231 ASN   B CA  1 
ATOM   3771 C  C   . ASN   B 1 231 ? -24.59848 8.08267   -52.18780 1.000 10.85965 ? 231 ASN   B C   1 
ATOM   3772 O  O   . ASN   B 1 231 ? -25.76677 8.05100   -51.78340 1.000 10.50983 ? 231 ASN   B O   1 
ATOM   3773 C  CB  . ASN   B 1 231 ? -22.81500 7.03145   -50.78039 1.000 12.51379 ? 231 ASN   B CB  1 
ATOM   3774 C  CG  . ASN   B 1 231 ? -22.46378 5.70562   -50.13586 1.000 15.30743 ? 231 ASN   B CG  1 
ATOM   3775 O  OD1 . ASN   B 1 231 ? -23.32938 5.02109   -49.59096 1.000 13.82745 ? 231 ASN   B OD1 1 
ATOM   3776 N  ND2 . ASN   B 1 231 ? -21.18534 5.34405   -50.17893 1.000 8.91228  ? 231 ASN   B ND2 1 
ATOM   3777 N  N   . HIS   B 1 232 ? -24.07823 9.16041   -52.78123 1.000 12.66004 ? 232 HIS   B N   1 
ATOM   3778 C  CA  . HIS   B 1 232 ? -24.87829 10.36628  -52.96924 1.000 10.49997 ? 232 HIS   B CA  1 
ATOM   3779 C  C   . HIS   B 1 232 ? -26.00284 10.13589  -53.97098 1.000 13.94439 ? 232 HIS   B C   1 
ATOM   3780 O  O   . HIS   B 1 232 ? -27.13530 10.58127  -53.74929 1.000 14.43086 ? 232 HIS   B O   1 
ATOM   3781 C  CB  . HIS   B 1 232 ? -23.98514 11.52186  -53.42008 1.000 12.43763 ? 232 HIS   B CB  1 
ATOM   3782 C  CG  . HIS   B 1 232 ? -24.71628 12.81527  -53.60805 1.000 15.25305 ? 232 HIS   B CG  1 
ATOM   3783 N  ND1 . HIS   B 1 232 ? -25.39234 13.44523  -52.58505 1.000 13.58707 ? 232 HIS   B ND1 1 
ATOM   3784 C  CD2 . HIS   B 1 232 ? -24.87608 13.59748  -54.70194 1.000 12.68614 ? 232 HIS   B CD2 1 
ATOM   3785 C  CE1 . HIS   B 1 232 ? -25.93498 14.56058  -53.04009 1.000 13.36769 ? 232 HIS   B CE1 1 
ATOM   3786 N  NE2 . HIS   B 1 232 ? -25.63804 14.67553  -54.32211 1.000 16.20792 ? 232 HIS   B NE2 1 
ATOM   3787 N  N   . HIS   B 1 233 ? -25.70686 9.45425   -55.08297 1.000 12.19590 ? 233 HIS   B N   1 
ATOM   3788 C  CA  . HIS   B 1 233 ? -26.74602 9.11882   -56.05386 1.000 12.39613 ? 233 HIS   B CA  1 
ATOM   3789 C  C   . HIS   B 1 233 ? -27.90217 8.39072   -55.38134 1.000 16.07597 ? 233 HIS   B C   1 
ATOM   3790 O  O   . HIS   B 1 233 ? -29.07318 8.73499   -55.58019 1.000 14.80327 ? 233 HIS   B O   1 
ATOM   3791 C  CB  . HIS   B 1 233 ? -26.16579 8.25551   -57.17626 1.000 12.01963 ? 233 HIS   B CB  1 
ATOM   3792 C  CG  . HIS   B 1 233 ? -25.00344 8.87533   -57.88674 1.000 15.00398 ? 233 HIS   B CG  1 
ATOM   3793 N  ND1 . HIS   B 1 233 ? -24.96311 10.20951  -58.23047 1.000 12.03719 ? 233 HIS   B ND1 1 
ATOM   3794 C  CD2 . HIS   B 1 233 ? -23.84092 8.33795   -58.32692 1.000 11.10785 ? 233 HIS   B CD2 1 
ATOM   3795 C  CE1 . HIS   B 1 233 ? -23.82435 10.46769  -58.84878 1.000 11.65949 ? 233 HIS   B CE1 1 
ATOM   3796 N  NE2 . HIS   B 1 233 ? -23.12566 9.34896   -58.92029 1.000 14.81060 ? 233 HIS   B NE2 1 
ATOM   3797 N  N   . LEU   B 1 234 ? -27.58395 7.37432   -54.57799 1.000 13.91023 ? 234 LEU   B N   1 
ATOM   3798 C  CA  . LEU   B 1 234 ? -28.61171 6.62777   -53.86079 1.000 16.09458 ? 234 LEU   B CA  1 
ATOM   3799 C  C   . LEU   B 1 234 ? -29.41553 7.53656   -52.94242 1.000 12.88180 ? 234 LEU   B C   1 
ATOM   3800 O  O   . LEU   B 1 234 ? -30.65185 7.51143   -52.95043 1.000 13.84992 ? 234 LEU   B O   1 
ATOM   3801 C  CB  . LEU   B 1 234 ? -27.96343 5.50226   -53.05813 1.000 9.85183  ? 234 LEU   B CB  1 
ATOM   3802 C  CG  . LEU   B 1 234 ? -27.56492 4.25524   -53.83593 1.000 11.38629 ? 234 LEU   B CG  1 
ATOM   3803 C  CD1 . LEU   B 1 234 ? -26.57923 3.41481   -53.04329 1.000 11.10474 ? 234 LEU   B CD1 1 
ATOM   3804 C  CD2 . LEU   B 1 234 ? -28.81560 3.46219   -54.14692 1.000 14.71823 ? 234 LEU   B CD2 1 
ATOM   3805 N  N   . ALA   B 1 235 ? -28.72305 8.34630   -52.13754 1.000 12.97512 ? 235 ALA   B N   1 
ATOM   3806 C  CA  . ALA   B 1 235 ? -29.40658 9.19305   -51.16640 1.000 14.93776 ? 235 ALA   B CA  1 
ATOM   3807 C  C   . ALA   B 1 235 ? -30.35900 10.16324  -51.85089 1.000 15.23869 ? 235 ALA   B C   1 
ATOM   3808 O  O   . ALA   B 1 235 ? -31.47746 10.38275  -51.37498 1.000 16.66518 ? 235 ALA   B O   1 
ATOM   3809 C  CB  . ALA   B 1 235 ? -28.38415 9.94851   -50.31831 1.000 13.53680 ? 235 ALA   B CB  1 
ATOM   3810 N  N   . VAL   B 1 236 ? -29.94012 10.74384  -52.97580 1.000 12.94720 ? 236 VAL   B N   1 
ATOM   3811 C  CA  . VAL   B 1 236 ? -30.81015 11.66305  -53.70281 1.000 12.94505 ? 236 VAL   B CA  1 
ATOM   3812 C  C   . VAL   B 1 236 ? -31.96772 10.90722  -54.34232 1.000 15.96883 ? 236 VAL   B C   1 
ATOM   3813 O  O   . VAL   B 1 236 ? -33.12618 11.33329  -54.26546 1.000 15.90753 ? 236 VAL   B O   1 
ATOM   3814 C  CB  . VAL   B 1 236 ? -30.00403 12.44875  -54.75125 1.000 13.24585 ? 236 VAL   B CB  1 
ATOM   3815 C  CG1 . VAL   B 1 236 ? -30.92750 13.33138  -55.57420 1.000 11.74544 ? 236 VAL   B CG1 1 
ATOM   3816 C  CG2 . VAL   B 1 236 ? -28.93564 13.28023  -54.07149 1.000 14.14251 ? 236 VAL   B CG2 1 
ATOM   3817 N  N   . GLY   B 1 237 ? -31.67089 9.77212   -54.97939 1.000 14.78437 ? 237 GLY   B N   1 
ATOM   3818 C  CA  . GLY   B 1 237 ? -32.71314 9.01988   -55.65991 1.000 13.75432 ? 237 GLY   B CA  1 
ATOM   3819 C  C   . GLY   B 1 237 ? -33.81979 8.56751   -54.72687 1.000 17.59717 ? 237 GLY   B C   1 
ATOM   3820 O  O   . GLY   B 1 237 ? -34.99907 8.59582   -55.08796 1.000 21.26050 ? 237 GLY   B O   1 
ATOM   3821 N  N   . PHE   B 1 238 ? -33.45763 8.14532   -53.51361 1.000 16.38178 ? 238 PHE   B N   1 
ATOM   3822 C  CA  . PHE   B 1 238 ? -34.47086 7.76806   -52.53433 1.000 17.51059 ? 238 PHE   B CA  1 
ATOM   3823 C  C   . PHE   B 1 238 ? -35.12598 8.99287   -51.90612 1.000 15.94493 ? 238 PHE   B C   1 
ATOM   3824 O  O   . PHE   B 1 238 ? -36.33972 8.99572   -51.67400 1.000 17.95406 ? 238 PHE   B O   1 
ATOM   3825 C  CB  . PHE   B 1 238 ? -33.86161 6.88321   -51.44455 1.000 15.02909 ? 238 PHE   B CB  1 
ATOM   3826 C  CG  . PHE   B 1 238 ? -33.52187 5.49112   -51.90179 1.000 14.86772 ? 238 PHE   B CG  1 
ATOM   3827 C  CD1 . PHE   B 1 238 ? -34.51811 4.61366   -52.29571 1.000 18.02699 ? 238 PHE   B CD1 1 
ATOM   3828 C  CD2 . PHE   B 1 238 ? -32.20850 5.04954   -51.90570 1.000 19.95556 ? 238 PHE   B CD2 1 
ATOM   3829 C  CE1 . PHE   B 1 238 ? -34.20867 3.32877   -52.70677 1.000 19.61020 ? 238 PHE   B CE1 1 
ATOM   3830 C  CE2 . PHE   B 1 238 ? -31.89255 3.76551   -52.31397 1.000 17.46028 ? 238 PHE   B CE2 1 
ATOM   3831 C  CZ  . PHE   B 1 238 ? -32.89396 2.90442   -52.71423 1.000 16.19058 ? 238 PHE   B CZ  1 
ATOM   3832 N  N   . LYS   B 1 239 ? -34.33724 10.03534  -51.62194 1.000 17.76024 ? 239 LYS   B N   1 
ATOM   3833 C  CA  . LYS   B 1 239 ? -34.87455 11.24751  -51.00602 1.000 21.90538 ? 239 LYS   B CA  1 
ATOM   3834 C  C   . LYS   B 1 239 ? -36.02294 11.82755  -51.81801 1.000 24.19666 ? 239 LYS   B C   1 
ATOM   3835 O  O   . LYS   B 1 239 ? -37.04396 12.24452  -51.25866 1.000 25.23036 ? 239 LYS   B O   1 
ATOM   3836 C  CB  . LYS   B 1 239 ? -33.76571 12.29040  -50.85060 1.000 24.99696 ? 239 LYS   B CB  1 
ATOM   3837 C  CG  . LYS   B 1 239 ? -34.22912 13.65962  -50.37697 1.000 26.96343 ? 239 LYS   B CG  1 
ATOM   3838 C  CD  . LYS   B 1 239 ? -34.60623 13.63489  -48.90805 1.000 38.97273 ? 239 LYS   B CD  1 
ATOM   3839 C  CE  . LYS   B 1 239 ? -34.46463 15.00779  -48.27135 1.000 35.25532 ? 239 LYS   B CE  1 
ATOM   3840 N  NZ  . LYS   B 1 239 ? -34.73540 14.96954  -46.80598 1.000 36.19617 ? 239 LYS   B NZ  1 
ATOM   3841 N  N   . LEU   B 1 240 ? -35.87511 11.85530  -53.14321 1.000 18.86704 ? 240 LEU   B N   1 
ATOM   3842 C  CA  . LEU   B 1 240 ? -36.87933 12.47555  -53.99723 1.000 21.80997 ? 240 LEU   B CA  1 
ATOM   3843 C  C   . LEU   B 1 240 ? -38.21018 11.73701  -53.96530 1.000 24.38271 ? 240 LEU   B C   1 
ATOM   3844 O  O   . LEU   B 1 240 ? -39.23146 12.30993  -54.36020 1.000 23.85332 ? 240 LEU   B O   1 
ATOM   3845 C  CB  . LEU   B 1 240 ? -36.34836 12.56561  -55.42648 1.000 19.13734 ? 240 LEU   B CB  1 
ATOM   3846 C  CG  . LEU   B 1 240 ? -35.18367 13.54751  -55.55782 1.000 23.48501 ? 240 LEU   B CG  1 
ATOM   3847 C  CD1 . LEU   B 1 240 ? -34.48884 13.41106  -56.90086 1.000 19.42215 ? 240 LEU   B CD1 1 
ATOM   3848 C  CD2 . LEU   B 1 240 ? -35.68805 14.96420  -55.35068 1.000 27.37886 ? 240 LEU   B CD2 1 
ATOM   3849 N  N   . LEU   B 1 241 ? -38.22560 10.48464  -53.50212 1.000 25.69804 ? 241 LEU   B N   1 
ATOM   3850 C  CA  . LEU   B 1 241 ? -39.48678 9.77483   -53.32376 1.000 25.88565 ? 241 LEU   B CA  1 
ATOM   3851 C  C   . LEU   B 1 241 ? -40.38284 10.44990  -52.29577 1.000 26.32639 ? 241 LEU   B C   1 
ATOM   3852 O  O   . LEU   B 1 241 ? -41.60417 10.26547  -52.33520 1.000 30.04381 ? 241 LEU   B O   1 
ATOM   3853 C  CB  . LEU   B 1 241 ? -39.22397 8.32691   -52.90539 1.000 23.47212 ? 241 LEU   B CB  1 
ATOM   3854 C  CG  . LEU   B 1 241 ? -38.63375 7.39462   -53.96320 1.000 25.26156 ? 241 LEU   B CG  1 
ATOM   3855 C  CD1 . LEU   B 1 241 ? -38.22208 6.07048   -53.34148 1.000 22.53527 ? 241 LEU   B CD1 1 
ATOM   3856 C  CD2 . LEU   B 1 241 ? -39.64023 7.17203   -55.07602 1.000 22.56138 ? 241 LEU   B CD2 1 
ATOM   3857 N  N   . GLN   B 1 242 ? -39.80589 11.22949  -51.38269 1.000 23.74816 ? 242 GLN   B N   1 
ATOM   3858 C  CA  . GLN   B 1 242 ? -40.57272 11.87970  -50.33047 1.000 23.86137 ? 242 GLN   B CA  1 
ATOM   3859 C  C   . GLN   B 1 242 ? -41.19509 13.19838  -50.77149 1.000 31.89155 ? 242 GLN   B C   1 
ATOM   3860 O  O   . GLN   B 1 242 ? -41.96600 13.78532  -50.00415 1.000 30.60115 ? 242 GLN   B O   1 
ATOM   3861 C  CB  . GLN   B 1 242 ? -39.67859 12.09679  -49.10737 1.000 28.65403 ? 242 GLN   B CB  1 
ATOM   3862 C  CG  . GLN   B 1 242 ? -39.24320 10.79425  -48.45081 1.000 29.66365 ? 242 GLN   B CG  1 
ATOM   3863 C  CD  . GLN   B 1 242 ? -38.13026 10.98133  -47.44038 1.000 37.18602 ? 242 GLN   B CD  1 
ATOM   3864 O  OE1 . GLN   B 1 242 ? -37.66821 12.09737  -47.20536 1.000 39.34169 ? 242 GLN   B OE1 1 
ATOM   3865 N  NE2 . GLN   B 1 242 ? -37.69289 9.88306   -46.83481 1.000 36.63862 ? 242 GLN   B NE2 1 
ATOM   3866 N  N   . GLU   B 1 243 ? -40.88940 13.67389  -51.97615 1.000 28.85989 ? 243 GLU   B N   1 
ATOM   3867 C  CA  . GLU   B 1 243 ? -41.54290 14.86628  -52.49167 1.000 28.00171 ? 243 GLU   B CA  1 
ATOM   3868 C  C   . GLU   B 1 243 ? -43.00273 14.56387  -52.82875 1.000 29.30841 ? 243 GLU   B C   1 
ATOM   3869 O  O   . GLU   B 1 243 ? -43.39334 13.41203  -53.04158 1.000 28.05661 ? 243 GLU   B O   1 
ATOM   3870 C  CB  . GLU   B 1 243 ? -40.80466 15.39314  -53.72357 1.000 28.11487 ? 243 GLU   B CB  1 
ATOM   3871 C  CG  . GLU   B 1 243 ? -39.33342 15.71316  -53.47916 1.000 30.49799 ? 243 GLU   B CG  1 
ATOM   3872 C  CD  . GLU   B 1 243 ? -39.13137 16.94246  -52.61232 1.000 34.81567 ? 243 GLU   B CD  1 
ATOM   3873 O  OE1 . GLU   B 1 243 ? -40.00991 17.83008  -52.62047 1.000 41.68440 ? 243 GLU   B OE1 1 
ATOM   3874 O  OE2 . GLU   B 1 243 ? -38.09405 17.01979  -51.92008 1.000 43.56487 ? 243 GLU   B OE2 1 
ATOM   3875 N  N   . GLU   B 1 244 ? -43.81000 15.62466  -52.87753 1.000 30.35048 ? 244 GLU   B N   1 
ATOM   3876 C  CA  . GLU   B 1 244 ? -45.25715 15.48554  -53.01646 1.000 30.86934 ? 244 GLU   B CA  1 
ATOM   3877 C  C   . GLU   B 1 244 ? -45.62216 14.68712  -54.26516 1.000 31.24533 ? 244 GLU   B C   1 
ATOM   3878 O  O   . GLU   B 1 244 ? -45.21040 15.02859  -55.37905 1.000 35.99597 ? 244 GLU   B O   1 
ATOM   3879 C  CB  . GLU   B 1 244 ? -45.91348 16.86707  -53.05089 1.000 35.22380 ? 244 GLU   B CB  1 
ATOM   3880 C  CG  . GLU   B 1 244 ? -45.85594 17.62110  -51.73000 1.000 53.84607 ? 244 GLU   B CG  1 
ATOM   3881 C  CD  . GLU   B 1 244 ? -46.70581 16.97139  -50.65286 1.000 61.00053 ? 244 GLU   B CD  1 
ATOM   3882 O  OE1 . GLU   B 1 244 ? -46.18486 16.72555  -49.54712 1.000 63.39769 ? 244 GLU   B OE1 1 
ATOM   3883 O  OE2 . GLU   B 1 244 ? -47.89772 16.70703  -50.90670 1.000 60.83795 ? 244 GLU   B OE2 1 
ATOM   3884 N  N   . ASN   B 1 245 ? -46.38655 13.61047  -54.06380 1.000 28.73415 ? 245 ASN   B N   1 
ATOM   3885 C  CA  . ASN   B 1 245 ? -46.87265 12.74944  -55.14420 1.000 29.85723 ? 245 ASN   B CA  1 
ATOM   3886 C  C   . ASN   B 1 245 ? -45.72588 12.10933  -55.92518 1.000 33.19225 ? 245 ASN   B C   1 
ATOM   3887 O  O   . ASN   B 1 245 ? -45.82624 11.89148  -57.13488 1.000 32.59558 ? 245 ASN   B O   1 
ATOM   3888 C  CB  . ASN   B 1 245 ? -47.80644 13.51709  -56.08794 1.000 27.65935 ? 245 ASN   B CB  1 
ATOM   3889 C  CG  . ASN   B 1 245 ? -48.60535 12.59902  -56.99735 1.000 34.27819 ? 245 ASN   B CG  1 
ATOM   3890 O  OD1 . ASN   B 1 245 ? -48.77910 11.41508  -56.70590 1.000 31.82518 ? 245 ASN   B OD1 1 
ATOM   3891 N  ND2 . ASN   B 1 245 ? -49.08881 13.14095  -58.10900 1.000 35.37475 ? 245 ASN   B ND2 1 
ATOM   3892 N  N   . CYS   B 1 246 ? -44.62549 11.78968  -55.24453 1.000 30.92335 ? 246 CYS   B N   1 
ATOM   3893 C  CA  . CYS   B 1 246 ? -43.48169 11.17072  -55.89705 1.000 28.00480 ? 246 CYS   B CA  1 
ATOM   3894 C  C   . CYS   B 1 246 ? -43.19042 9.75577   -55.41857 1.000 26.85984 ? 246 CYS   B C   1 
ATOM   3895 O  O   . CYS   B 1 246 ? -42.33196 9.09155   -56.00835 1.000 23.13740 ? 246 CYS   B O   1 
ATOM   3896 C  CB  . CYS   B 1 246 ? -42.22268 12.03134  -55.70548 1.000 22.35889 ? 246 CYS   B CB  1 
ATOM   3897 S  SG  . CYS   B 1 246 ? -42.17431 13.54773  -56.69103 1.000 31.23530 ? 246 CYS   B SG  1 
ATOM   3898 N  N   . ASP   B 1 247 ? -43.87127 9.27174   -54.38166 1.000 24.92931 ? 247 ASP   B N   1 
ATOM   3899 C  CA  . ASP   B 1 247 ? -43.59327 7.93687   -53.85130 1.000 25.11557 ? 247 ASP   B CA  1 
ATOM   3900 C  C   . ASP   B 1 247 ? -44.22012 6.90359   -54.77929 1.000 28.03645 ? 247 ASP   B C   1 
ATOM   3901 O  O   . ASP   B 1 247 ? -45.34341 6.44238   -54.57058 1.000 25.28836 ? 247 ASP   B O   1 
ATOM   3902 C  CB  . ASP   B 1 247 ? -44.11374 7.79470   -52.42643 1.000 27.46460 ? 247 ASP   B CB  1 
ATOM   3903 C  CG  . ASP   B 1 247 ? -43.63784 6.51416   -51.75442 1.000 31.94644 ? 247 ASP   B CG  1 
ATOM   3904 O  OD1 . ASP   B 1 247 ? -43.06069 5.64471   -52.44345 1.000 25.93104 ? 247 ASP   B OD1 1 
ATOM   3905 O  OD2 . ASP   B 1 247 ? -43.84759 6.37454   -50.53164 1.000 35.18997 ? 247 ASP   B OD2 1 
ATOM   3906 N  N   . ILE   B 1 248 ? -43.46686 6.51760   -55.81234 1.000 24.10758 ? 248 ILE   B N   1 
ATOM   3907 C  CA  . ILE   B 1 248 ? -43.91870 5.48336   -56.73545 1.000 20.67703 ? 248 ILE   B CA  1 
ATOM   3908 C  C   . ILE   B 1 248 ? -43.95355 4.10176   -56.10147 1.000 25.59421 ? 248 ILE   B C   1 
ATOM   3909 O  O   . ILE   B 1 248 ? -44.42427 3.15137   -56.73571 1.000 21.05360 ? 248 ILE   B O   1 
ATOM   3910 C  CB  . ILE   B 1 248 ? -43.02300 5.45453   -57.99014 1.000 26.54769 ? 248 ILE   B CB  1 
ATOM   3911 C  CG1 . ILE   B 1 248 ? -41.58651 5.08953   -57.61008 1.000 25.59052 ? 248 ILE   B CG1 1 
ATOM   3912 C  CG2 . ILE   B 1 248 ? -43.05714 6.79927   -58.69644 1.000 26.13877 ? 248 ILE   B CG2 1 
ATOM   3913 C  CD1 . ILE   B 1 248 ? -40.72195 4.68876   -58.78776 1.000 20.48562 ? 248 ILE   B CD1 1 
ATOM   3914 N  N   . PHE   B 1 249 ? -43.46428 3.96245   -54.86926 1.000 23.00263 ? 249 PHE   B N   1 
ATOM   3915 C  CA  . PHE   B 1 249 ? -43.48506 2.69919   -54.14531 1.000 25.17025 ? 249 PHE   B CA  1 
ATOM   3916 C  C   . PHE   B 1 249 ? -44.54901 2.67799   -53.05440 1.000 25.97041 ? 249 PHE   B C   1 
ATOM   3917 O  O   . PHE   B 1 249 ? -44.49588 1.82591   -52.16061 1.000 28.02373 ? 249 PHE   B O   1 
ATOM   3918 C  CB  . PHE   B 1 249 ? -42.10693 2.41815   -53.54529 1.000 27.63552 ? 249 PHE   B CB  1 
ATOM   3919 C  CG  . PHE   B 1 249 ? -41.00664 2.36288   -54.56377 1.000 29.72797 ? 249 PHE   B CG  1 
ATOM   3920 C  CD1 . PHE   B 1 249 ? -41.14099 1.58829   -55.70313 1.000 25.83421 ? 249 PHE   B CD1 1 
ATOM   3921 C  CD2 . PHE   B 1 249 ? -39.84390 3.09565   -54.38963 1.000 26.32816 ? 249 PHE   B CD2 1 
ATOM   3922 C  CE1 . PHE   B 1 249 ? -40.13397 1.54051   -56.64868 1.000 27.81566 ? 249 PHE   B CE1 1 
ATOM   3923 C  CE2 . PHE   B 1 249 ? -38.83060 3.05021   -55.33018 1.000 22.49580 ? 249 PHE   B CE2 1 
ATOM   3924 C  CZ  . PHE   B 1 249 ? -38.97505 2.27029   -56.46012 1.000 22.90561 ? 249 PHE   B CZ  1 
ATOM   3925 N  N   . GLN   B 1 250 ? -45.52165 3.59229   -53.12305 1.000 26.18453 ? 250 GLN   B N   1 
ATOM   3926 C  CA  . GLN   B 1 250 ? -46.46732 3.77256   -52.02548 1.000 30.56898 ? 250 GLN   B CA  1 
ATOM   3927 C  C   . GLN   B 1 250 ? -47.33156 2.53911   -51.80042 1.000 25.02520 ? 250 GLN   B C   1 
ATOM   3928 O  O   . GLN   B 1 250 ? -47.76885 2.28960   -50.67173 1.000 26.49830 ? 250 GLN   B O   1 
ATOM   3929 C  CB  . GLN   B 1 250 ? -47.34845 4.99492   -52.29183 1.000 24.82474 ? 250 GLN   B CB  1 
ATOM   3930 C  CG  . GLN   B 1 250 ? -48.09195 4.95194   -53.61834 1.000 26.51651 ? 250 GLN   B CG  1 
ATOM   3931 C  CD  . GLN   B 1 250 ? -48.72621 6.28313   -53.97486 1.000 37.71866 ? 250 GLN   B CD  1 
ATOM   3932 O  OE1 . GLN   B 1 250 ? -48.04539 7.30568   -54.05785 1.000 36.33983 ? 250 GLN   B OE1 1 
ATOM   3933 N  NE2 . GLN   B 1 250 ? -50.03709 6.27652   -54.18826 1.000 34.48108 ? 250 GLN   B NE2 1 
ATOM   3934 N  N   . ASN   B 1 251 ? -47.58835 1.75645   -52.84741 1.000 25.73997 ? 251 ASN   B N   1 
ATOM   3935 C  CA  . ASN   B 1 251 ? -48.44115 0.58176   -52.74004 1.000 34.42153 ? 251 ASN   B CA  1 
ATOM   3936 C  C   . ASN   B 1 251 ? -47.64875 -0.71823  -52.74819 1.000 33.43196 ? 251 ASN   B C   1 
ATOM   3937 O  O   . ASN   B 1 251 ? -48.22234 -1.78978  -52.97214 1.000 28.20818 ? 251 ASN   B O   1 
ATOM   3938 C  CB  . ASN   B 1 251 ? -49.48825 0.59511   -53.85037 1.000 33.50948 ? 251 ASN   B CB  1 
ATOM   3939 C  CG  . ASN   B 1 251 ? -50.43987 1.76406   -53.71872 1.000 33.19890 ? 251 ASN   B CG  1 
ATOM   3940 O  OD1 . ASN   B 1 251 ? -50.79190 2.16567   -52.60918 1.000 30.88728 ? 251 ASN   B OD1 1 
ATOM   3941 N  ND2 . ASN   B 1 251 ? -50.84297 2.33241   -54.84462 1.000 34.17128 ? 251 ASN   B ND2 1 
ATOM   3942 N  N   . LEU   B 1 252 ? -46.34390 -0.64279  -52.51578 1.000 30.23530 ? 252 LEU   B N   1 
ATOM   3943 C  CA  . LEU   B 1 252 ? -45.57844 -1.82371  -52.16353 1.000 32.53233 ? 252 LEU   B CA  1 
ATOM   3944 C  C   . LEU   B 1 252 ? -45.72941 -2.09240  -50.67632 1.000 30.17881 ? 252 LEU   B C   1 
ATOM   3945 O  O   . LEU   B 1 252 ? -45.84335 -1.16731  -49.86502 1.000 37.47320 ? 252 LEU   B O   1 
ATOM   3946 C  CB  . LEU   B 1 252 ? -44.09716 -1.64937  -52.50483 1.000 32.28949 ? 252 LEU   B CB  1 
ATOM   3947 C  CG  . LEU   B 1 252 ? -43.61929 -1.94099  -53.92926 1.000 28.29604 ? 252 LEU   B CG  1 
ATOM   3948 C  CD1 . LEU   B 1 252 ? -44.17379 -0.93054  -54.91940 1.000 25.12671 ? 252 LEU   B CD1 1 
ATOM   3949 C  CD2 . LEU   B 1 252 ? -42.09868 -1.96940  -53.98393 1.000 21.91977 ? 252 LEU   B CD2 1 
ATOM   3950 N  N   . THR   B 1 253 ? -45.74795 -3.37235  -50.32182 1.000 30.12831 ? 253 THR   B N   1 
ATOM   3951 C  CA  . THR   B 1 253 ? -45.72764 -3.70907  -48.91378 1.000 32.45218 ? 253 THR   B CA  1 
ATOM   3952 C  C   . THR   B 1 253 ? -44.42403 -3.23315  -48.30369 1.000 38.38724 ? 253 THR   B C   1 
ATOM   3953 O  O   . THR   B 1 253 ? -43.43045 -2.98113  -48.99012 1.000 30.66282 ? 253 THR   B O   1 
ATOM   3954 C  CB  . THR   B 1 253 ? -45.87517 -5.21047  -48.69157 1.000 34.33759 ? 253 THR   B CB  1 
ATOM   3955 O  OG1 . THR   B 1 253 ? -44.63984 -5.86758  -49.00611 1.000 36.18601 ? 253 THR   B OG1 1 
ATOM   3956 C  CG2 . THR   B 1 253 ? -46.98110 -5.76465  -49.55979 1.000 37.00509 ? 253 THR   B CG2 1 
ATOM   3957 N  N   . LYS   B 1 254 ? -44.44232 -3.10018  -46.98986 1.000 36.35770 ? 254 LYS   B N   1 
ATOM   3958 C  CA  . LYS   B 1 254 ? -43.25381 -2.63402  -46.30383 1.000 38.26573 ? 254 LYS   B CA  1 
ATOM   3959 C  C   . LYS   B 1 254 ? -42.07506 -3.57905  -46.55648 1.000 35.05606 ? 254 LYS   B C   1 
ATOM   3960 O  O   . LYS   B 1 254 ? -40.95348 -3.12599  -46.81111 1.000 31.68134 ? 254 LYS   B O   1 
ATOM   3961 C  CB  . LYS   B 1 254 ? -43.60588 -2.46599  -44.82473 1.000 40.02874 ? 254 LYS   B CB  1 
ATOM   3962 C  CG  . LYS   B 1 254 ? -42.46448 -2.15598  -43.87906 1.000 47.79830 ? 254 LYS   B CG  1 
ATOM   3963 C  CD  . LYS   B 1 254 ? -41.80275 -3.37705  -43.25244 1.000 53.70802 ? 254 LYS   B CD  1 
ATOM   3964 C  CE  . LYS   B 1 254 ? -42.13722 -3.53380  -41.79438 1.000 55.84899 ? 254 LYS   B CE  1 
ATOM   3965 N  NZ  . LYS   B 1 254 ? -41.27661 -4.61525  -41.29905 1.000 56.98608 ? 254 LYS   B NZ  1 
ATOM   3966 N  N   . LYS   B 1 255 ? -42.32652 -4.89525  -46.56823 1.000 33.82374 ? 255 LYS   B N   1 
ATOM   3967 C  CA  . LYS   B 1 255 ? -41.26406 -5.86343  -46.85298 1.000 32.00939 ? 255 LYS   B CA  1 
ATOM   3968 C  C   . LYS   B 1 255 ? -40.76236 -5.77546  -48.29349 1.000 33.10321 ? 255 LYS   B C   1 
ATOM   3969 O  O   . LYS   B 1 255 ? -39.57247 -6.00206  -48.54533 1.000 27.98235 ? 255 LYS   B O   1 
ATOM   3970 C  CB  . LYS   B 1 255 ? -41.74914 -7.28342  -46.55504 1.000 31.66887 ? 255 LYS   B CB  1 
ATOM   3971 C  CG  . LYS   B 1 255 ? -41.32731 -7.81508  -45.19644 1.000 36.50895 ? 255 LYS   B CG  1 
ATOM   3972 C  CD  . LYS   B 1 255 ? -40.00106 -8.54838  -45.28318 1.000 44.81544 ? 255 LYS   B CD  1 
ATOM   3973 C  CE  . LYS   B 1 255 ? -39.27224 -8.52446  -43.95349 1.000 42.90923 ? 255 LYS   B CE  1 
ATOM   3974 N  NZ  . LYS   B 1 255 ? -38.08497 -9.42001  -43.97287 1.000 44.61485 ? 255 LYS   B NZ  1 
ATOM   3975 N  N   . GLN   B 1 256 ? -41.64625 -5.47828  -49.25048 1.000 31.99322 ? 256 GLN   B N   1 
ATOM   3976 C  CA  . GLN   B 1 256 ? -41.19607 -5.23169  -50.61784 1.000 30.64415 ? 256 GLN   B CA  1 
ATOM   3977 C  C   . GLN   B 1 256 ? -40.33237 -3.98025  -50.69065 1.000 29.33924 ? 256 GLN   B C   1 
ATOM   3978 O  O   . GLN   B 1 256 ? -39.29938 -3.96964  -51.37072 1.000 23.28767 ? 256 GLN   B O   1 
ATOM   3979 C  CB  . GLN   B 1 256 ? -42.39514 -5.09292  -51.55348 1.000 31.62046 ? 256 GLN   B CB  1 
ATOM   3980 C  CG  . GLN   B 1 256 ? -43.11186 -6.38498  -51.87344 1.000 27.30548 ? 256 GLN   B CG  1 
ATOM   3981 C  CD  . GLN   B 1 256 ? -44.43837 -6.13813  -52.55993 1.000 29.85911 ? 256 GLN   B CD  1 
ATOM   3982 O  OE1 . GLN   B 1 256 ? -45.18254 -5.23054  -52.18710 1.000 34.30353 ? 256 GLN   B OE1 1 
ATOM   3983 N  NE2 . GLN   B 1 256 ? -44.73764 -6.93720  -53.57536 1.000 33.68102 ? 256 GLN   B NE2 1 
ATOM   3984 N  N   . ARG   B 1 257 ? -40.74813 -2.91374  -50.00070 1.000 27.05386 ? 257 ARG   B N   1 
ATOM   3985 C  CA  . ARG   B 1 257 ? -39.95884 -1.68734  -49.97682 1.000 29.11990 ? 257 ARG   B CA  1 
ATOM   3986 C  C   . ARG   B 1 257 ? -38.55872 -1.94119  -49.43308 1.000 24.39761 ? 257 ARG   B C   1 
ATOM   3987 O  O   . ARG   B 1 257 ? -37.57273 -1.43146  -49.97829 1.000 25.31036 ? 257 ARG   B O   1 
ATOM   3988 C  CB  . ARG   B 1 257 ? -40.66509 -0.61743  -49.14334 1.000 29.70675 ? 257 ARG   B CB  1 
ATOM   3989 C  CG  . ARG   B 1 257 ? -42.05323 -0.23843  -49.62730 1.000 34.26312 ? 257 ARG   B CG  1 
ATOM   3990 C  CD  . ARG   B 1 257 ? -42.52831 1.02169   -48.92327 1.000 35.58287 ? 257 ARG   B CD  1 
ATOM   3991 N  NE  . ARG   B 1 257 ? -41.72842 2.18099   -49.30890 1.000 43.66460 ? 257 ARG   B NE  1 
ATOM   3992 C  CZ  . ARG   B 1 257 ? -42.23939 3.34806   -49.68612 1.000 40.37590 ? 257 ARG   B CZ  1 
ATOM   3993 N  NH1 . ARG   B 1 257 ? -43.55355 3.51969   -49.71173 1.000 39.63347 ? 257 ARG   B NH1 1 
ATOM   3994 N  NH2 . ARG   B 1 257 ? -41.43676 4.34749   -50.02750 1.000 44.92626 ? 257 ARG   B NH2 1 
ATOM   3995 N  N   . GLN   B 1 258 ? -38.45011 -2.73405  -48.36279 1.000 24.65705 ? 258 GLN   B N   1 
ATOM   3996 C  CA  . GLN   B 1 258 ? -37.14393 -3.01687  -47.76965 1.000 26.39072 ? 258 GLN   B CA  1 
ATOM   3997 C  C   . GLN   B 1 258 ? -36.26015 -3.82834  -48.70067 1.000 24.69055 ? 258 GLN   B C   1 
ATOM   3998 O  O   . GLN   B 1 258 ? -35.07227 -3.52774  -48.86149 1.000 17.73910 ? 258 GLN   B O   1 
ATOM   3999 C  CB  . GLN   B 1 258 ? -37.29895 -3.75100  -46.44100 1.000 31.97403 ? 258 GLN   B CB  1 
ATOM   4000 C  CG  . GLN   B 1 258 ? -38.18541 -3.05240  -45.44828 1.000 42.63492 ? 258 GLN   B CG  1 
ATOM   4001 C  CD  . GLN   B 1 258 ? -38.40186 -3.88176  -44.20739 1.000 49.06561 ? 258 GLN   B CD  1 
ATOM   4002 O  OE1 . GLN   B 1 258 ? -38.68297 -3.34790  -43.13511 1.000 53.19211 ? 258 GLN   B OE1 1 
ATOM   4003 N  NE2 . GLN   B 1 258 ? -38.27058 -5.19545  -44.34467 1.000 38.70575 ? 258 GLN   B NE2 1 
ATOM   4004 N  N   . SER   B 1 259 ? -36.80515 -4.90117  -49.27077 1.000 19.59175 ? 259 SER   B N   1 
ATOM   4005 C  CA  . SER   B 1 259 ? -36.01642 -5.71623  -50.18349 1.000 22.31961 ? 259 SER   B CA  1 
ATOM   4006 C  C   . SER   B 1 259 ? -35.58451 -4.90791  -51.39674 1.000 21.48407 ? 259 SER   B C   1 
ATOM   4007 O  O   . SER   B 1 259 ? -34.42554 -4.98164  -51.82281 1.000 19.31228 ? 259 SER   B O   1 
ATOM   4008 C  CB  . SER   B 1 259 ? -36.81887 -6.93838  -50.61416 1.000 25.35580 ? 259 SER   B CB  1 
ATOM   4009 O  OG  . SER   B 1 259 ? -36.14873 -7.62549  -51.65346 1.000 22.10059 ? 259 SER   B OG  1 
ATOM   4010 N  N   . LEU   B 1 260 ? -36.50693 -4.13020  -51.96282 1.000 18.86557 ? 260 LEU   B N   1 
ATOM   4011 C  CA  . LEU   B 1 260 ? -36.17658 -3.29952  -53.11316 1.000 21.63183 ? 260 LEU   B CA  1 
ATOM   4012 C  C   . LEU   B 1 260 ? -35.09048 -2.29155  -52.76302 1.000 20.60481 ? 260 LEU   B C   1 
ATOM   4013 O  O   . LEU   B 1 260 ? -34.13252 -2.10624  -53.52186 1.000 18.39719 ? 260 LEU   B O   1 
ATOM   4014 C  CB  . LEU   B 1 260 ? -37.43565 -2.59494  -53.61461 1.000 20.06536 ? 260 LEU   B CB  1 
ATOM   4015 C  CG  . LEU   B 1 260 ? -37.29037 -1.52107  -54.68725 1.000 23.31484 ? 260 LEU   B CG  1 
ATOM   4016 C  CD1 . LEU   B 1 260 ? -36.46761 -2.03491  -55.82576 1.000 28.99490 ? 260 LEU   B CD1 1 
ATOM   4017 C  CD2 . LEU   B 1 260 ? -38.66016 -1.13284  -55.18029 1.000 30.59164 ? 260 LEU   B CD2 1 
ATOM   4018 N  N   . ARG   B 1 261 ? -35.22107 -1.63769  -51.60647 1.000 19.00166 ? 261 ARG   B N   1 
ATOM   4019 C  CA  . ARG   B 1 261 ? -34.23340 -0.64701  -51.18960 1.000 20.28094 ? 261 ARG   B CA  1 
ATOM   4020 C  C   . ARG   B 1 261 ? -32.84129 -1.25916  -51.09567 1.000 16.78035 ? 261 ARG   B C   1 
ATOM   4021 O  O   . ARG   B 1 261 ? -31.86478 -0.68800  -51.59484 1.000 14.98367 ? 261 ARG   B O   1 
ATOM   4022 C  CB  . ARG   B 1 261 ? -34.64490 -0.03554  -49.85146 1.000 16.80603 ? 261 ARG   B CB  1 
ATOM   4023 C  CG  . ARG   B 1 261 ? -33.58531 0.84115   -49.22241 1.000 14.36818 ? 261 ARG   B CG  1 
ATOM   4024 C  CD  . ARG   B 1 261 ? -34.13556 1.57734   -48.01442 1.000 14.03711 ? 261 ARG   B CD  1 
ATOM   4025 N  NE  . ARG   B 1 261 ? -33.08443 2.28807   -47.29310 1.000 18.75194 ? 261 ARG   B NE  1 
ATOM   4026 C  CZ  . ARG   B 1 261 ? -32.57392 3.45459   -47.67508 1.000 17.40364 ? 261 ARG   B CZ  1 
ATOM   4027 N  NH1 . ARG   B 1 261 ? -33.01536 4.04747   -48.77578 1.000 13.97345 ? 261 ARG   B NH1 1 
ATOM   4028 N  NH2 . ARG   B 1 261 ? -31.61725 4.02837   -46.95766 1.000 15.83457 ? 261 ARG   B NH2 1 
ATOM   4029 N  N   . LYS   B 1 262 ? -32.73295 -2.42986  -50.46215 1.000 15.38855 ? 262 LYS   B N   1 
ATOM   4030 C  CA  . LYS   B 1 262 ? -31.43431 -3.08426  -50.33569 1.000 17.62908 ? 262 LYS   B CA  1 
ATOM   4031 C  C   . LYS   B 1 262 ? -30.84905 -3.42857  -51.69939 1.000 19.75295 ? 262 LYS   B C   1 
ATOM   4032 O  O   . LYS   B 1 262 ? -29.65585 -3.21129  -51.94359 1.000 16.48987 ? 262 LYS   B O   1 
ATOM   4033 C  CB  . LYS   B 1 262 ? -31.55676 -4.34547  -49.48204 1.000 20.06643 ? 262 LYS   B CB  1 
ATOM   4034 C  CG  . LYS   B 1 262 ? -30.30852 -5.21000  -49.51835 1.000 18.97953 ? 262 LYS   B CG  1 
ATOM   4035 C  CD  . LYS   B 1 262 ? -30.52085 -6.55627  -48.85471 1.000 24.33550 ? 262 LYS   B CD  1 
ATOM   4036 C  CE  . LYS   B 1 262 ? -29.27775 -7.41834  -48.99501 1.000 35.91175 ? 262 LYS   B CE  1 
ATOM   4037 N  NZ  . LYS   B 1 262 ? -28.07133 -6.71678  -48.47401 1.000 36.00554 ? 262 LYS   B NZ  1 
ATOM   4038 N  N   . MET   B 1 263 ? -31.67193 -3.97214  -52.59992 1.000 15.18025 ? 263 MET   B N   1 
ATOM   4039 C  CA  . MET   B 1 263 ? -31.17473 -4.34282  -53.92085 1.000 18.90692 ? 263 MET   B CA  1 
ATOM   4040 C  C   . MET   B 1 263 ? -30.70073 -3.12144  -54.69674 1.000 16.78886 ? 263 MET   B C   1 
ATOM   4041 O  O   . MET   B 1 263 ? -29.64579 -3.15907  -55.33998 1.000 15.28962 ? 263 MET   B O   1 
ATOM   4042 C  CB  . MET   B 1 263 ? -32.25424 -5.09286  -54.70088 1.000 21.62872 ? 263 MET   B CB  1 
ATOM   4043 C  CG  . MET   B 1 263 ? -32.58888 -6.45523  -54.11695 1.000 21.96017 ? 263 MET   B CG  1 
ATOM   4044 S  SD  . MET   B 1 263 ? -33.64708 -7.45318  -55.17969 1.000 22.57388 ? 263 MET   B SD  1 
ATOM   4045 C  CE  . MET   B 1 263 ? -35.16110 -6.49920  -55.14508 1.000 20.40525 ? 263 MET   B CE  1 
ATOM   4046 N  N   . VAL   B 1 264 ? -31.46186 -2.02637  -54.64275 1.000 16.64251 ? 264 VAL   B N   1 
ATOM   4047 C  CA  . VAL   B 1 264 ? -31.05464 -0.80450  -55.33268 1.000 16.53577 ? 264 VAL   B CA  1 
ATOM   4048 C  C   . VAL   B 1 264 ? -29.72786 -0.30194  -54.77894 1.000 14.61330 ? 264 VAL   B C   1 
ATOM   4049 O  O   . VAL   B 1 264 ? -28.82932 0.09143   -55.53180 1.000 14.40793 ? 264 VAL   B O   1 
ATOM   4050 C  CB  . VAL   B 1 264 ? -32.15253 0.26822   -55.22508 1.000 17.09479 ? 264 VAL   B CB  1 
ATOM   4051 C  CG1 . VAL   B 1 264 ? -31.66169 1.58281   -55.80451 1.000 12.72332 ? 264 VAL   B CG1 1 
ATOM   4052 C  CG2 . VAL   B 1 264 ? -33.40217 -0.18386  -55.94950 1.000 17.49088 ? 264 VAL   B CG2 1 
ATOM   4053 N  N   . ILE   B 1 265 ? -29.58459 -0.31484  -53.45181 1.000 12.93994 ? 265 ILE   B N   1 
ATOM   4054 C  CA  . ILE   B 1 265 ? -28.32873 0.10033   -52.83126 1.000 13.17354 ? 265 ILE   B CA  1 
ATOM   4055 C  C   . ILE   B 1 265 ? -27.18693 -0.79804  -53.28857 1.000 12.54635 ? 265 ILE   B C   1 
ATOM   4056 O  O   . ILE   B 1 265 ? -26.12501 -0.31914  -53.70377 1.000 13.05566 ? 265 ILE   B O   1 
ATOM   4057 C  CB  . ILE   B 1 265 ? -28.46042 0.10255   -51.29827 1.000 16.75511 ? 265 ILE   B CB  1 
ATOM   4058 C  CG1 . ILE   B 1 265 ? -29.39055 1.22467   -50.83889 1.000 13.41518 ? 265 ILE   B CG1 1 
ATOM   4059 C  CG2 . ILE   B 1 265 ? -27.09633 0.24706   -50.65001 1.000 11.07153 ? 265 ILE   B CG2 1 
ATOM   4060 C  CD1 . ILE   B 1 265 ? -29.71575 1.16986   -49.36142 1.000 12.67611 ? 265 ILE   B CD1 1 
ATOM   4061 N  N   . ASP   B 1 266 ? -27.38915 -2.11659  -53.21642 1.000 14.61265 ? 266 ASP   B N   1 
ATOM   4062 C  CA  . ASP   B 1 266 ? -26.35300 -3.05076  -53.64658 1.000 13.69355 ? 266 ASP   B CA  1 
ATOM   4063 C  C   . ASP   B 1 266 ? -25.97476 -2.82670  -55.10376 1.000 13.13163 ? 266 ASP   B C   1 
ATOM   4064 O  O   . ASP   B 1 266 ? -24.79585 -2.90828  -55.46773 1.000 12.40085 ? 266 ASP   B O   1 
ATOM   4065 C  CB  . ASP   B 1 266 ? -26.82229 -4.49031  -53.44065 1.000 19.44589 ? 266 ASP   B CB  1 
ATOM   4066 C  CG  . ASP   B 1 266 ? -26.81598 -4.90271  -51.98525 1.000 22.93469 ? 266 ASP   B CG  1 
ATOM   4067 O  OD1 . ASP   B 1 266 ? -26.02127 -4.33245  -51.21130 1.000 21.14775 ? 266 ASP   B OD1 1 
ATOM   4068 O  OD2 . ASP   B 1 266 ? -27.59799 -5.80386  -51.61692 1.000 27.79765 ? 266 ASP   B OD2 1 
ATOM   4069 N  N   . ILE   B 1 267 ? -26.96160 -2.54019  -55.95205 1.000 12.31922 ? 267 ILE   B N   1 
ATOM   4070 C  CA  . ILE   B 1 267 ? -26.69046 -2.37537  -57.37542 1.000 14.48822 ? 267 ILE   B CA  1 
ATOM   4071 C  C   . ILE   B 1 267 ? -25.92332 -1.08327  -57.63086 1.000 14.43317 ? 267 ILE   B C   1 
ATOM   4072 O  O   . ILE   B 1 267 ? -24.88767 -1.08324  -58.30624 1.000 13.72972 ? 267 ILE   B O   1 
ATOM   4073 C  CB  . ILE   B 1 267 ? -28.00140 -2.42200  -58.17883 1.000 17.22127 ? 267 ILE   B CB  1 
ATOM   4074 C  CG1 . ILE   B 1 267 ? -28.57453 -3.84081  -58.17592 1.000 14.41393 ? 267 ILE   B CG1 1 
ATOM   4075 C  CG2 . ILE   B 1 267 ? -27.76434 -1.94690  -59.59647 1.000 11.32051 ? 267 ILE   B CG2 1 
ATOM   4076 C  CD1 . ILE   B 1 267 ? -29.99146 -3.93226  -58.69990 1.000 17.02751 ? 267 ILE   B CD1 1 
ATOM   4077 N  N   . VAL   B 1 268 ? -26.41764 0.03689   -57.09601 1.000 9.84938  ? 268 VAL   B N   1 
ATOM   4078 C  CA  . VAL   B 1 268 ? -25.81414 1.33342   -57.40051 1.000 11.81486 ? 268 VAL   B CA  1 
ATOM   4079 C  C   . VAL   B 1 268 ? -24.39887 1.41749   -56.84565 1.000 11.20408 ? 268 VAL   B C   1 
ATOM   4080 O  O   . VAL   B 1 268 ? -23.48337 1.90843   -57.51790 1.000 12.94542 ? 268 VAL   B O   1 
ATOM   4081 C  CB  . VAL   B 1 268 ? -26.69589 2.47625   -56.86879 1.000 13.61927 ? 268 VAL   B CB  1 
ATOM   4082 C  CG1 . VAL   B 1 268 ? -26.01633 3.81581   -57.09783 1.000 11.03083 ? 268 VAL   B CG1 1 
ATOM   4083 C  CG2 . VAL   B 1 268 ? -28.05077 2.45349   -57.54941 1.000 14.83203 ? 268 VAL   B CG2 1 
ATOM   4084 N  N   . LEU   B 1 269 ? -24.19328 0.94336   -55.61387 1.000 9.35824  ? 269 LEU   B N   1 
ATOM   4085 C  CA  . LEU   B 1 269 ? -22.85309 0.96951   -55.03661 1.000 14.02810 ? 269 LEU   B CA  1 
ATOM   4086 C  C   . LEU   B 1 269 ? -21.85789 0.19074   -55.88845 1.000 13.40806 ? 269 LEU   B C   1 
ATOM   4087 O  O   . LEU   B 1 269 ? -20.65882 0.49203   -55.87143 1.000 16.76283 ? 269 LEU   B O   1 
ATOM   4088 C  CB  . LEU   B 1 269 ? -22.88038 0.42322   -53.60825 1.000 11.26789 ? 269 LEU   B CB  1 
ATOM   4089 C  CG  . LEU   B 1 269 ? -23.44512 1.36517   -52.54206 1.000 11.54373 ? 269 LEU   B CG  1 
ATOM   4090 C  CD1 . LEU   B 1 269 ? -23.38920 0.71321   -51.16882 1.000 12.05310 ? 269 LEU   B CD1 1 
ATOM   4091 C  CD2 . LEU   B 1 269 ? -22.69390 2.68985   -52.54441 1.000 12.38430 ? 269 LEU   B CD2 1 
ATOM   4092 N  N   . ALA   B 1 270 ? -22.33446 -0.79304  -56.65402 1.000 13.30444 ? 270 ALA   B N   1 
ATOM   4093 C  CA  . ALA   B 1 270 ? -21.47025 -1.58067  -57.52346 1.000 17.56018 ? 270 ALA   B CA  1 
ATOM   4094 C  C   . ALA   B 1 270 ? -21.10822 -0.87120  -58.82347 1.000 15.79543 ? 270 ALA   B C   1 
ATOM   4095 O  O   . ALA   B 1 270 ? -20.28118 -1.39405  -59.57795 1.000 15.71598 ? 270 ALA   B O   1 
ATOM   4096 C  CB  . ALA   B 1 270 ? -22.12837 -2.92473  -57.84667 1.000 16.31442 ? 270 ALA   B CB  1 
ATOM   4097 N  N   . THR   B 1 271 ? -21.70350 0.28752   -59.11695 1.000 12.62249 ? 271 THR   B N   1 
ATOM   4098 C  CA  . THR   B 1 271 ? -21.29372 1.04796   -60.29240 1.000 14.29999 ? 271 THR   B CA  1 
ATOM   4099 C  C   . THR   B 1 271 ? -20.00165 1.82013   -60.06573 1.000 17.73856 ? 271 THR   B C   1 
ATOM   4100 O  O   . THR   B 1 271 ? -19.40762 2.30078   -61.03775 1.000 17.01776 ? 271 THR   B O   1 
ATOM   4101 C  CB  . THR   B 1 271 ? -22.39731 2.01755   -60.72565 1.000 12.90265 ? 271 THR   B CB  1 
ATOM   4102 O  OG1 . THR   B 1 271 ? -22.70278 2.91333   -59.65031 1.000 10.66394 ? 271 THR   B OG1 1 
ATOM   4103 C  CG2 . THR   B 1 271 ? -23.65238 1.25703   -61.12579 1.000 10.17728 ? 271 THR   B CG2 1 
ATOM   4104 N  N   . ASP   B 1 272 ? -19.56998 1.95623   -58.81312 1.000 15.64968 ? 272 ASP   B N   1 
ATOM   4105 C  CA  . ASP   B 1 272 ? -18.26181 2.51639   -58.49914 1.000 15.60701 ? 272 ASP   B CA  1 
ATOM   4106 C  C   . ASP   B 1 272 ? -17.17812 1.72344   -59.21985 1.000 19.67900 ? 272 ASP   B C   1 
ATOM   4107 O  O   . ASP   B 1 272 ? -17.03033 0.51821   -58.99633 1.000 16.57497 ? 272 ASP   B O   1 
ATOM   4108 C  CB  . ASP   B 1 272 ? -18.04636 2.48001   -56.98375 1.000 16.54040 ? 272 ASP   B CB  1 
ATOM   4109 C  CG  . ASP   B 1 272 ? -16.79122 3.21677   -56.53734 1.000 21.53527 ? 272 ASP   B CG  1 
ATOM   4110 O  OD1 . ASP   B 1 272 ? -15.91799 3.51701   -57.37853 1.000 15.94420 ? 272 ASP   B OD1 1 
ATOM   4111 O  OD2 . ASP   B 1 272 ? -16.68024 3.49246   -55.32372 1.000 15.70181 ? 272 ASP   B OD2 1 
ATOM   4112 N  N   . MET   B 1 273 ? -16.41697 2.40263   -60.08440 1.000 19.01983 ? 273 MET   B N   1 
ATOM   4113 C  CA  . MET   B 1 273 ? -15.41235 1.71488   -60.89106 1.000 19.23496 ? 273 MET   B CA  1 
ATOM   4114 C  C   . MET   B 1 273 ? -14.31433 1.07608   -60.05121 1.000 20.67296 ? 273 MET   B C   1 
ATOM   4115 O  O   . MET   B 1 273 ? -13.67038 0.13001   -60.51763 1.000 22.34952 ? 273 MET   B O   1 
ATOM   4116 C  CB  . MET   B 1 273 ? -14.78762 2.67427   -61.90607 1.000 19.91802 ? 273 MET   B CB  1 
ATOM   4117 C  CG  . MET   B 1 273 ? -15.48719 2.68967   -63.25774 1.000 27.67062 ? 273 MET   B CG  1 
ATOM   4118 S  SD  . MET   B 1 273 ? -15.46405 1.08605   -64.09164 1.000 29.54071 ? 273 MET   B SD  1 
ATOM   4119 C  CE  . MET   B 1 273 ? -13.71196 0.70854   -64.09420 1.000 29.29380 ? 273 MET   B CE  1 
ATOM   4120 N  N   . SER   B 1 274 ? -14.07814 1.56413   -58.83109 1.000 22.13189 ? 274 SER   B N   1 
ATOM   4121 C  CA  . SER   B 1 274 ? -13.11175 0.90822   -57.95780 1.000 21.20818 ? 274 SER   B CA  1 
ATOM   4122 C  C   . SER   B 1 274 ? -13.55236 -0.49133  -57.55014 1.000 23.15351 ? 274 SER   B C   1 
ATOM   4123 O  O   . SER   B 1 274 ? -12.73268 -1.25194  -57.02510 1.000 20.83545 ? 274 SER   B O   1 
ATOM   4124 C  CB  . SER   B 1 274 ? -12.85545 1.75876   -56.71011 1.000 21.94300 ? 274 SER   B CB  1 
ATOM   4125 O  OG  . SER   B 1 274 ? -14.01704 1.87001   -55.90775 1.000 22.44172 ? 274 SER   B OG  1 
ATOM   4126 N  N   . LYS   B 1 275 ? -14.81407 -0.84645  -57.78136 1.000 21.12986 ? 275 LYS   B N   1 
ATOM   4127 C  CA  . LYS   B 1 275 ? -15.32156 -2.18491  -57.51585 1.000 19.01219 ? 275 LYS   B CA  1 
ATOM   4128 C  C   . LYS   B 1 275 ? -15.25761 -3.09539  -58.73411 1.000 21.55292 ? 275 LYS   B C   1 
ATOM   4129 O  O   . LYS   B 1 275 ? -15.63570 -4.26686  -58.63018 1.000 22.89826 ? 275 LYS   B O   1 
ATOM   4130 C  CB  . LYS   B 1 275 ? -16.77041 -2.11185  -57.02072 1.000 18.50936 ? 275 LYS   B CB  1 
ATOM   4131 C  CG  . LYS   B 1 275 ? -16.95648 -1.32252  -55.73858 1.000 21.80218 ? 275 LYS   B CG  1 
ATOM   4132 C  CD  . LYS   B 1 275 ? -15.84173 -1.62046  -54.75094 1.000 29.63073 ? 275 LYS   B CD  1 
ATOM   4133 C  CE  . LYS   B 1 275 ? -16.38945 -2.13028  -53.42927 1.000 34.42853 ? 275 LYS   B CE  1 
ATOM   4134 N  NZ  . LYS   B 1 275 ? -16.78135 -1.01463  -52.52331 1.000 35.55423 ? 275 LYS   B NZ  1 
ATOM   4135 N  N   . HIS   B 1 276 ? -14.78430 -2.58783  -59.87556 1.000 18.48341 ? 276 HIS   B N   1 
ATOM   4136 C  CA  . HIS   B 1 276 ? -14.89201 -3.32569  -61.13214 1.000 20.84908 ? 276 HIS   B CA  1 
ATOM   4137 C  C   . HIS   B 1 276 ? -14.16726 -4.66451  -61.06649 1.000 20.22201 ? 276 HIS   B C   1 
ATOM   4138 O  O   . HIS   B 1 276 ? -14.72637 -5.70298  -61.43809 1.000 21.53476 ? 276 HIS   B O   1 
ATOM   4139 C  CB  . HIS   B 1 276 ? -14.34336 -2.48188  -62.28329 1.000 19.31260 ? 276 HIS   B CB  1 
ATOM   4140 C  CG  . HIS   B 1 276 ? -14.09463 -3.26190  -63.53735 1.000 22.00972 ? 276 HIS   B CG  1 
ATOM   4141 N  ND1 . HIS   B 1 276 ? -15.10063 -3.59727  -64.41764 1.000 17.61964 ? 276 HIS   B ND1 1 
ATOM   4142 C  CD2 . HIS   B 1 276 ? -12.95405 -3.77437  -64.05759 1.000 18.16007 ? 276 HIS   B CD2 1 
ATOM   4143 C  CE1 . HIS   B 1 276 ? -14.59134 -4.28178  -65.42613 1.000 19.98148 ? 276 HIS   B CE1 1 
ATOM   4144 N  NE2 . HIS   B 1 276 ? -13.29061 -4.40354  -65.23168 1.000 22.15461 ? 276 HIS   B NE2 1 
ATOM   4145 N  N   . MET   B 1 277 ? -12.91665 -4.65984  -60.60028 1.000 18.77440 ? 277 MET   B N   1 
ATOM   4146 C  CA  . MET   B 1 277 ? -12.09493 -5.86491  -60.67720 1.000 25.35787 ? 277 MET   B CA  1 
ATOM   4147 C  C   . MET   B 1 277 ? -12.67130 -6.98978  -59.82390 1.000 26.31412 ? 277 MET   B C   1 
ATOM   4148 O  O   . MET   B 1 277 ? -12.75639 -8.13949  -60.27103 1.000 22.47022 ? 277 MET   B O   1 
ATOM   4149 C  CB  . MET   B 1 277 ? -10.65640 -5.54785  -60.26674 1.000 21.85481 ? 277 MET   B CB  1 
ATOM   4150 C  CG  . MET   B 1 277 ? -9.91692  -4.65883  -61.25807 1.000 28.83623 ? 277 MET   B CG  1 
ATOM   4151 S  SD  . MET   B 1 277 ? -9.85809  -5.38101  -62.91093 1.000 44.54549 ? 277 MET   B SD  1 
ATOM   4152 C  CE  . MET   B 1 277 ? -9.02596  -4.08469  -63.82486 1.000 33.70402 ? 277 MET   B CE  1 
ATOM   4153 N  N   . ASN   B 1 278 ? -13.07341 -6.67913  -58.58887 1.000 29.22139 ? 278 ASN   B N   1 
ATOM   4154 C  CA  . ASN   B 1 278 ? -13.70198 -7.69395  -57.74734 1.000 28.00431 ? 278 ASN   B CA  1 
ATOM   4155 C  C   . ASN   B 1 278 ? -15.03345 -8.14578  -58.33203 1.000 27.65525 ? 278 ASN   B C   1 
ATOM   4156 O  O   . ASN   B 1 278 ? -15.38868 -9.32747  -58.24650 1.000 27.41557 ? 278 ASN   B O   1 
ATOM   4157 C  CB  . ASN   B 1 278 ? -13.90081 -7.15928  -56.33001 1.000 30.70163 ? 278 ASN   B CB  1 
ATOM   4158 C  CG  . ASN   B 1 278 ? -12.59418 -6.82561  -55.64480 1.000 42.02529 ? 278 ASN   B CG  1 
ATOM   4159 O  OD1 . ASN   B 1 278 ? -11.54973 -7.39176  -55.96604 1.000 39.01226 ? 278 ASN   B OD1 1 
ATOM   4160 N  ND2 . ASN   B 1 278 ? -12.64646 -5.90838  -54.68568 1.000 43.52094 ? 278 ASN   B ND2 1 
ATOM   4161 N  N   . LEU   B 1 279 ? -15.78503 -7.21370  -58.92036 1.000 24.45280 ? 279 LEU   B N   1 
ATOM   4162 C  CA  . LEU   B 1 279 ? -17.05498 -7.55674  -59.55105 1.000 25.46221 ? 279 LEU   B CA  1 
ATOM   4163 C  C   . LEU   B 1 279 ? -16.84112 -8.51769  -60.71405 1.000 26.26693 ? 279 LEU   B C   1 
ATOM   4164 O  O   . LEU   B 1 279 ? -17.56120 -9.51291  -60.85765 1.000 28.30533 ? 279 LEU   B O   1 
ATOM   4165 C  CB  . LEU   B 1 279 ? -17.74922 -6.27759  -60.02206 1.000 27.93201 ? 279 LEU   B CB  1 
ATOM   4166 C  CG  . LEU   B 1 279 ? -19.27254 -6.21903  -60.12214 1.000 25.26714 ? 279 LEU   B CG  1 
ATOM   4167 C  CD1 . LEU   B 1 279 ? -19.90911 -6.77897  -58.86576 1.000 26.01552 ? 279 LEU   B CD1 1 
ATOM   4168 C  CD2 . LEU   B 1 279 ? -19.71870 -4.78190  -60.34834 1.000 27.47637 ? 279 LEU   B CD2 1 
ATOM   4169 N  N   . LEU   B 1 280 ? -15.83940 -8.23630  -61.55050 1.000 26.77636 ? 280 LEU   B N   1 
ATOM   4170 C  CA  . LEU   B 1 280 ? -15.57111 -9.07647  -62.71289 1.000 28.46174 ? 280 LEU   B CA  1 
ATOM   4171 C  C   . LEU   B 1 280 ? -15.02199 -10.43806 -62.30385 1.000 27.68861 ? 280 LEU   B C   1 
ATOM   4172 O  O   . LEU   B 1 280 ? -15.38505 -11.46101 -62.89692 1.000 25.45456 ? 280 LEU   B O   1 
ATOM   4173 C  CB  . LEU   B 1 280 ? -14.59782 -8.36283  -63.64992 1.000 25.45686 ? 280 LEU   B CB  1 
ATOM   4174 C  CG  . LEU   B 1 280 ? -14.10281 -9.12492  -64.87815 1.000 24.81756 ? 280 LEU   B CG  1 
ATOM   4175 C  CD1 . LEU   B 1 280 ? -15.24710 -9.41364  -65.83694 1.000 22.55051 ? 280 LEU   B CD1 1 
ATOM   4176 C  CD2 . LEU   B 1 280 ? -13.00681 -8.32983  -65.56535 1.000 24.84414 ? 280 LEU   B CD2 1 
ATOM   4177 N  N   . ALA   B 1 281 ? -14.13262 -10.46876 -61.30579 1.000 29.48231 ? 281 ALA   B N   1 
ATOM   4178 C  CA  . ALA   B 1 281 ? -13.61750 -11.74141 -60.80895 1.000 30.52610 ? 281 ALA   B CA  1 
ATOM   4179 C  C   . ALA   B 1 281 ? -14.75046 -12.63129 -60.32718 1.000 31.93344 ? 281 ALA   B C   1 
ATOM   4180 O  O   . ALA   B 1 281 ? -14.75108 -13.84527 -60.56721 1.000 38.53898 ? 281 ALA   B O   1 
ATOM   4181 C  CB  . ALA   B 1 281 ? -12.61819 -11.50011 -59.67781 1.000 30.90941 ? 281 ALA   B CB  1 
ATOM   4182 N  N   . ASP   B 1 282 ? -15.73052 -12.03465 -59.65100 1.000 29.17338 ? 282 ASP   B N   1 
ATOM   4183 C  CA  . ASP   B 1 282 ? -16.87194 -12.79045 -59.16125 1.000 35.80646 ? 282 ASP   B CA  1 
ATOM   4184 C  C   . ASP   B 1 282 ? -17.80334 -13.20135 -60.29590 1.000 36.23677 ? 282 ASP   B C   1 
ATOM   4185 O  O   . ASP   B 1 282 ? -18.43136 -14.26347 -60.22127 1.000 37.57781 ? 282 ASP   B O   1 
ATOM   4186 C  CB  . ASP   B 1 282 ? -17.60727 -11.96943 -58.10159 1.000 37.02181 ? 282 ASP   B CB  1 
ATOM   4187 C  CG  . ASP   B 1 282 ? -16.96883 -12.07842 -56.73075 1.000 38.89823 ? 282 ASP   B CG  1 
ATOM   4188 O  OD1 . ASP   B 1 282 ? -16.35801 -13.12844 -56.44381 1.000 40.34812 ? 282 ASP   B OD1 1 
ATOM   4189 O  OD2 . ASP   B 1 282 ? -17.08879 -11.12462 -55.93338 1.000 33.17630 ? 282 ASP   B OD2 1 
ATOM   4190 N  N   . LEU   B 1 283 ? -17.90237 -12.38636 -61.35114 1.000 30.13028 ? 283 LEU   B N   1 
ATOM   4191 C  CA  . LEU   B 1 283 ? -18.65374 -12.79918 -62.53377 1.000 28.76969 ? 283 LEU   B CA  1 
ATOM   4192 C  C   . LEU   B 1 283 ? -17.96869 -13.96653 -63.23532 1.000 35.02742 ? 283 LEU   B C   1 
ATOM   4193 O  O   . LEU   B 1 283 ? -18.63566 -14.89029 -63.71769 1.000 30.05783 ? 283 LEU   B O   1 
ATOM   4194 C  CB  . LEU   B 1 283 ? -18.82039 -11.61716 -63.49230 1.000 30.82202 ? 283 LEU   B CB  1 
ATOM   4195 C  CG  . LEU   B 1 283 ? -19.77570 -11.79602 -64.67799 1.000 28.65413 ? 283 LEU   B CG  1 
ATOM   4196 C  CD1 . LEU   B 1 283 ? -21.19515 -12.05418 -64.19816 1.000 30.28387 ? 283 LEU   B CD1 1 
ATOM   4197 C  CD2 . LEU   B 1 283 ? -19.73312 -10.59104 -65.61399 1.000 26.12803 ? 283 LEU   B CD2 1 
ATOM   4198 N  N   . LYS   B 1 284 ? -16.63411 -13.93986 -63.30121 1.000 29.96253 ? 284 LYS   B N   1 
ATOM   4199 C  CA  . LYS   B 1 284 ? -15.88908 -15.04442 -63.89949 1.000 34.75415 ? 284 LYS   B CA  1 
ATOM   4200 C  C   . LYS   B 1 284 ? -16.10367 -16.33681 -63.12186 1.000 36.47505 ? 284 LYS   B C   1 
ATOM   4201 O  O   . LYS   B 1 284 ? -16.38359 -17.38799 -63.71003 1.000 40.45022 ? 284 LYS   B O   1 
ATOM   4202 C  CB  . LYS   B 1 284 ? -14.39982 -14.70362 -63.96130 1.000 30.00653 ? 284 LYS   B CB  1 
ATOM   4203 C  CG  . LYS   B 1 284 ? -13.99004 -13.82634 -65.12889 1.000 30.41707 ? 284 LYS   B CG  1 
ATOM   4204 C  CD  . LYS   B 1 284 ? -12.48985 -13.57872 -65.10014 1.000 24.20021 ? 284 LYS   B CD  1 
ATOM   4205 C  CE  . LYS   B 1 284 ? -12.06049 -12.60511 -66.18338 1.000 27.51036 ? 284 LYS   B CE  1 
ATOM   4206 N  NZ  . LYS   B 1 284 ? -10.65647 -12.14397 -65.99116 1.000 28.05396 ? 284 LYS   B NZ  1 
ATOM   4207 N  N   . THR   B 1 285 ? -15.95928 -16.27670 -61.79284 1.000 36.39163 ? 285 THR   B N   1 
ATOM   4208 C  CA  . THR   B 1 285 ? -16.21163 -17.44341 -60.95011 1.000 38.37354 ? 285 THR   B CA  1 
ATOM   4209 C  C   . THR   B 1 285 ? -17.57530 -18.05454 -61.24473 1.000 39.06731 ? 285 THR   B C   1 
ATOM   4210 O  O   . THR   B 1 285 ? -17.70841 -19.27969 -61.35223 1.000 42.93859 ? 285 THR   B O   1 
ATOM   4211 C  CB  . THR   B 1 285 ? -16.11364 -17.05418 -59.47112 1.000 37.14926 ? 285 THR   B CB  1 
ATOM   4212 O  OG1 . THR   B 1 285 ? -14.75379 -16.74743 -59.13889 1.000 33.28972 ? 285 THR   B OG1 1 
ATOM   4213 C  CG2 . THR   B 1 285 ? -16.60889 -18.18511 -58.57608 1.000 41.96653 ? 285 THR   B CG2 1 
ATOM   4214 N  N   . MET   B 1 286 ? -18.59711 -17.21038 -61.40245 1.000 31.10124 ? 286 MET   B N   1 
ATOM   4215 C  CA  . MET   B 1 286 ? -19.94427 -17.71195 -61.65101 1.000 33.67730 ? 286 MET   B CA  1 
ATOM   4216 C  C   . MET   B 1 286 ? -20.04857 -18.38559 -63.01395 1.000 40.54956 ? 286 MET   B C   1 
ATOM   4217 O  O   . MET   B 1 286 ? -20.72771 -19.40953 -63.15420 1.000 45.26524 ? 286 MET   B O   1 
ATOM   4218 C  CB  . MET   B 1 286 ? -20.95410 -16.57237 -61.53937 1.000 35.81055 ? 286 MET   B CB  1 
ATOM   4219 C  CG  . MET   B 1 286 ? -22.34974 -16.94956 -61.99035 1.000 37.00455 ? 286 MET   B CG  1 
ATOM   4220 S  SD  . MET   B 1 286 ? -23.53971 -15.64212 -61.67746 1.000 55.39532 ? 286 MET   B SD  1 
ATOM   4221 C  CE  . MET   B 1 286 ? -23.05929 -15.12707 -60.03117 1.000 33.62969 ? 286 MET   B CE  1 
ATOM   4222 N  N   . VAL   B 1 287 ? -19.39090 -17.82456 -64.03191 1.000 35.68447 ? 287 VAL   B N   1 
ATOM   4223 C  CA  . VAL   B 1 287 ? -19.41270 -18.44317 -65.35450 1.000 34.11820 ? 287 VAL   B CA  1 
ATOM   4224 C  C   . VAL   B 1 287 ? -18.76245 -19.81970 -65.31469 1.000 39.77700 ? 287 VAL   B C   1 
ATOM   4225 O  O   . VAL   B 1 287 ? -19.20094 -20.74485 -66.01049 1.000 41.39060 ? 287 VAL   B O   1 
ATOM   4226 C  CB  . VAL   B 1 287 ? -18.73373 -17.51772 -66.38529 1.000 36.86724 ? 287 VAL   B CB  1 
ATOM   4227 C  CG1 . VAL   B 1 287 ? -18.40940 -18.27567 -67.66312 1.000 31.51194 ? 287 VAL   B CG1 1 
ATOM   4228 C  CG2 . VAL   B 1 287 ? -19.62617 -16.32547 -66.69103 1.000 32.10618 ? 287 VAL   B CG2 1 
ATOM   4229 N  N   . GLU   B 1 288 ? -17.72829 -19.98886 -64.48741 1.000 39.22707 ? 288 GLU   B N   1 
ATOM   4230 C  CA  . GLU   B 1 288 ? -17.05194 -21.27967 -64.40399 1.000 41.45278 ? 288 GLU   B CA  1 
ATOM   4231 C  C   . GLU   B 1 288 ? -17.94538 -22.33949 -63.77121 1.000 44.08674 ? 288 GLU   B C   1 
ATOM   4232 O  O   . GLU   B 1 288 ? -17.92333 -23.50456 -64.18478 1.000 47.20015 ? 288 GLU   B O   1 
ATOM   4233 C  CB  . GLU   B 1 288 ? -15.75017 -21.14188 -63.61656 1.000 44.49219 ? 288 GLU   B CB  1 
ATOM   4234 C  CG  . GLU   B 1 288 ? -14.74995 -20.18072 -64.22890 1.000 46.72286 ? 288 GLU   B CG  1 
ATOM   4235 C  CD  . GLU   B 1 288 ? -13.32414 -20.50866 -63.83735 1.000 61.25428 ? 288 GLU   B CD  1 
ATOM   4236 O  OE1 . GLU   B 1 288 ? -12.94601 -20.23667 -62.67820 1.000 61.40210 ? 288 GLU   B OE1 1 
ATOM   4237 O  OE2 . GLU   B 1 288 ? -12.58385 -21.04631 -64.68823 1.000 68.97625 ? 288 GLU   B OE2 1 
ATOM   4238 N  N   . THR   B 1 289 ? -18.73017 -21.95947 -62.76259 1.000 44.68489 ? 289 THR   B N   1 
ATOM   4239 C  CA  . THR   B 1 289 ? -19.63719 -22.87206 -62.07707 1.000 43.37478 ? 289 THR   B CA  1 
ATOM   4240 C  C   . THR   B 1 289 ? -21.07875 -22.70446 -62.54918 1.000 43.07171 ? 289 THR   B C   1 
ATOM   4241 O  O   . THR   B 1 289 ? -22.02120 -22.96000 -61.79186 1.000 51.77268 ? 289 THR   B O   1 
ATOM   4242 C  CB  . THR   B 1 289 ? -19.53439 -22.67231 -60.56545 1.000 42.85922 ? 289 THR   B CB  1 
ATOM   4243 O  OG1 . THR   B 1 289 ? -20.17419 -21.44434 -60.19816 1.000 49.45091 ? 289 THR   B OG1 1 
ATOM   4244 C  CG2 . THR   B 1 289 ? -18.07155 -22.60898 -60.14663 1.000 39.73321 ? 289 THR   B CG2 1 
ATOM   4245 N  N   . LYS   B 1 290 ? -21.25420 -22.29599 -63.80348 1.000 42.06247 ? 290 LYS   B N   1 
ATOM   4246 C  CA  . LYS   B 1 290 ? -22.56094 -21.95893 -64.35047 1.000 40.50860 ? 290 LYS   B CA  1 
ATOM   4247 C  C   . LYS   B 1 290 ? -23.46240 -23.18809 -64.43692 1.000 43.30086 ? 290 LYS   B C   1 
ATOM   4248 O  O   . LYS   B 1 290 ? -22.99784 -24.32000 -64.59668 1.000 43.56492 ? 290 LYS   B O   1 
ATOM   4249 C  CB  . LYS   B 1 290 ? -22.37729 -21.33263 -65.73419 1.000 34.51892 ? 290 LYS   B CB  1 
ATOM   4250 C  CG  . LYS   B 1 290 ? -23.63573 -20.83362 -66.39692 1.000 38.78894 ? 290 LYS   B CG  1 
ATOM   4251 C  CD  . LYS   B 1 290 ? -23.31878 -20.03342 -67.65192 1.000 40.95721 ? 290 LYS   B CD  1 
ATOM   4252 C  CE  . LYS   B 1 290 ? -23.16483 -20.93290 -68.86654 1.000 37.95308 ? 290 LYS   B CE  1 
ATOM   4253 N  NZ  . LYS   B 1 290 ? -23.59379 -20.24146 -70.11478 1.000 41.26412 ? 290 LYS   B NZ  1 
ATOM   4254 N  N   . LYS   B 1 291 ? -24.77069 -22.95332 -64.31711 1.000 39.25090 ? 291 LYS   B N   1 
ATOM   4255 C  CA  . LYS   B 1 291 ? -25.78361 -23.99553 -64.44656 1.000 39.64576 ? 291 LYS   B CA  1 
ATOM   4256 C  C   . LYS   B 1 291 ? -26.99930 -23.40812 -65.14327 1.000 40.73160 ? 291 LYS   B C   1 
ATOM   4257 O  O   . LYS   B 1 291 ? -27.44615 -22.31195 -64.79306 1.000 40.25014 ? 291 LYS   B O   1 
ATOM   4258 C  CB  . LYS   B 1 291 ? -26.19241 -24.56700 -63.08223 1.000 38.15249 ? 291 LYS   B CB  1 
ATOM   4259 C  CG  . LYS   B 1 291 ? -25.03501 -25.05279 -62.22930 1.000 50.48457 ? 291 LYS   B CG  1 
ATOM   4260 C  CD  . LYS   B 1 291 ? -25.42593 -25.16571 -60.76700 1.000 51.14899 ? 291 LYS   B CD  1 
ATOM   4261 C  CE  . LYS   B 1 291 ? -24.31329 -24.64554 -59.86781 1.000 52.06482 ? 291 LYS   B CE  1 
ATOM   4262 N  NZ  . LYS   B 1 291 ? -23.75572 -25.70680 -58.98448 1.000 46.25982 ? 291 LYS   B NZ  1 
ATOM   4263 N  N   . VAL   B 1 292 ? -27.53710 -24.12907 -66.12697 1.000 34.33083 ? 292 VAL   B N   1 
ATOM   4264 C  CA  . VAL   B 1 292 ? -28.68905 -23.64385 -66.87435 1.000 39.44999 ? 292 VAL   B CA  1 
ATOM   4265 C  C   . VAL   B 1 292 ? -29.70295 -24.75545 -67.08153 1.000 45.76464 ? 292 VAL   B C   1 
ATOM   4266 O  O   . VAL   B 1 292 ? -29.38437 -25.94549 -67.04488 1.000 33.63945 ? 292 VAL   B O   1 
ATOM   4267 C  CB  . VAL   B 1 292 ? -28.32157 -23.05913 -68.25687 1.000 46.12480 ? 292 VAL   B CB  1 
ATOM   4268 C  CG1 . VAL   B 1 292 ? -27.54765 -21.77099 -68.11303 1.000 47.38704 ? 292 VAL   B CG1 1 
ATOM   4269 C  CG2 . VAL   B 1 292 ? -27.55996 -24.08085 -69.09252 1.000 40.58025 ? 292 VAL   B CG2 1 
ATOM   4270 N  N   . THR   B 1 293 ? -30.93597 -24.33015 -67.33848 1.000 49.80923 ? 293 THR   B N   1 
ATOM   4271 C  CA  . THR   B 1 293 ? -31.98297 -25.19069 -67.85306 1.000 50.15461 ? 293 THR   B CA  1 
ATOM   4272 C  C   . THR   B 1 293 ? -31.53982 -25.75162 -69.20904 1.000 59.85362 ? 293 THR   B C   1 
ATOM   4273 O  O   . THR   B 1 293 ? -30.53716 -25.32245 -69.78624 1.000 60.56699 ? 293 THR   B O   1 
ATOM   4274 C  CB  . THR   B 1 293 ? -33.27399 -24.37331 -67.96637 1.000 57.62757 ? 293 THR   B CB  1 
ATOM   4275 O  OG1 . THR   B 1 293 ? -33.52361 -23.74109 -66.70154 1.000 58.35107 ? 293 THR   B OG1 1 
ATOM   4276 C  CG2 . THR   B 1 293 ? -34.52970 -25.24476 -68.44912 1.000 60.74137 ? 293 THR   B CG2 1 
ATOM   4277 N  N   . SER   B 1 294 ? -32.28003 -26.75078 -69.70626 1.000 70.28378 ? 294 SER   B N   1 
ATOM   4278 C  CA  . SER   B 1 294 ? -32.14540 -27.14203 -71.10728 1.000 75.61663 ? 294 SER   B CA  1 
ATOM   4279 C  C   . SER   B 1 294 ? -32.91930 -26.19894 -72.02300 1.000 73.12606 ? 294 SER   B C   1 
ATOM   4280 O  O   . SER   B 1 294 ? -32.49937 -25.95694 -73.15928 1.000 72.42240 ? 294 SER   B O   1 
ATOM   4281 C  CB  . SER   B 1 294 ? -32.60404 -28.58961 -71.30857 1.000 73.98916 ? 294 SER   B CB  1 
ATOM   4282 O  OG  . SER   B 1 294 ? -34.01115 -28.72450 -71.20939 1.000 73.03563 ? 294 SER   B OG  1 
ATOM   4283 N  N   . SER   B 1 295 ? -34.04660 -25.66465 -71.54414 1.000 70.93827 ? 295 SER   B N   1 
ATOM   4284 C  CA  . SER   B 1 295 ? -34.67740 -24.50979 -72.17733 1.000 73.00595 ? 295 SER   B CA  1 
ATOM   4285 C  C   . SER   B 1 295 ? -33.69589 -23.36020 -72.34898 1.000 72.14519 ? 295 SER   B C   1 
ATOM   4286 O  O   . SER   B 1 295 ? -33.86897 -22.52100 -73.24118 1.000 69.97387 ? 295 SER   B O   1 
ATOM   4287 C  CB  . SER   B 1 295 ? -35.87949 -24.05615 -71.34477 1.000 62.29858 ? 295 SER   B CB  1 
ATOM   4288 O  OG  . SER   B 1 295 ? -36.51988 -22.94274 -71.92098 1.000 57.96157 ? 295 SER   B OG  1 
ATOM   4289 N  N   . GLY   B 1 296 ? -32.66336 -23.30539 -71.50291 1.000 69.78138 ? 296 GLY   B N   1 
ATOM   4290 C  CA  . GLY   B 1 296 ? -31.55258 -22.38025 -71.64832 1.000 62.36854 ? 296 GLY   B CA  1 
ATOM   4291 C  C   . GLY   B 1 296 ? -31.40158 -21.42072 -70.48446 1.000 57.55949 ? 296 GLY   B C   1 
ATOM   4292 O  O   . GLY   B 1 296 ? -30.31204 -20.87854 -70.27268 1.000 61.26788 ? 296 GLY   B O   1 
ATOM   4293 N  N   . VAL   B 1 297 ? -32.47468 -21.21201 -69.71854 1.000 53.45313 ? 297 VAL   B N   1 
ATOM   4294 C  CA  . VAL   B 1 297 ? -32.47545 -20.18648 -68.68271 1.000 53.97382 ? 297 VAL   B CA  1 
ATOM   4295 C  C   . VAL   B 1 297 ? -31.43463 -20.49032 -67.61180 1.000 54.97659 ? 297 VAL   B C   1 
ATOM   4296 O  O   . VAL   B 1 297 ? -31.29021 -21.63239 -67.15591 1.000 50.12570 ? 297 VAL   B O   1 
ATOM   4297 C  CB  . VAL   B 1 297 ? -33.88026 -20.06561 -68.07072 1.000 57.08964 ? 297 VAL   B CB  1 
ATOM   4298 C  CG1 . VAL   B 1 297 ? -33.97250 -18.83071 -67.18215 1.000 55.03153 ? 297 VAL   B CG1 1 
ATOM   4299 C  CG2 . VAL   B 1 297 ? -34.93571 -20.03712 -69.17262 1.000 59.19665 ? 297 VAL   B CG2 1 
ATOM   4300 N  N   . LEU   B 1 298 ? -30.71532 -19.44943 -67.19401 1.000 52.16924 ? 298 LEU   B N   1 
ATOM   4301 C  CA  . LEU   B 1 298 ? -29.67676 -19.58716 -66.18146 1.000 48.00800 ? 298 LEU   B CA  1 
ATOM   4302 C  C   . LEU   B 1 298 ? -30.28764 -19.94292 -64.83025 1.000 37.18409 ? 298 LEU   B C   1 
ATOM   4303 O  O   . LEU   B 1 298 ? -31.37238 -19.47157 -64.47773 1.000 46.05246 ? 298 LEU   B O   1 
ATOM   4304 C  CB  . LEU   B 1 298 ? -28.87877 -18.28642 -66.07858 1.000 41.24447 ? 298 LEU   B CB  1 
ATOM   4305 C  CG  . LEU   B 1 298 ? -27.53202 -18.28066 -65.35911 1.000 33.87159 ? 298 LEU   B CG  1 
ATOM   4306 C  CD1 . LEU   B 1 298 ? -26.49671 -18.94969 -66.21845 1.000 36.50718 ? 298 LEU   B CD1 1 
ATOM   4307 C  CD2 . LEU   B 1 298 ? -27.11045 -16.85753 -65.06395 1.000 40.04085 ? 298 LEU   B CD2 1 
ATOM   4308 N  N   . LEU   B 1 299 ? -29.58183 -20.78015 -64.06980 1.000 34.24173 ? 299 LEU   B N   1 
ATOM   4309 C  CA  . LEU   B 1 299 ? -30.06608 -21.29574 -62.78895 1.000 33.73035 ? 299 LEU   B CA  1 
ATOM   4310 C  C   . LEU   B 1 299 ? -29.25430 -20.67323 -61.65488 1.000 32.18755 ? 299 LEU   B C   1 
ATOM   4311 O  O   . LEU   B 1 299 ? -28.13469 -21.10736 -61.36791 1.000 36.66932 ? 299 LEU   B O   1 
ATOM   4312 C  CB  . LEU   B 1 299 ? -29.98886 -22.82004 -62.75334 1.000 35.26262 ? 299 LEU   B CB  1 
ATOM   4313 C  CG  . LEU   B 1 299 ? -30.95433 -23.57202 -63.67248 1.000 32.74532 ? 299 LEU   B CG  1 
ATOM   4314 C  CD1 . LEU   B 1 299 ? -30.73994 -25.07539 -63.56911 1.000 29.95545 ? 299 LEU   B CD1 1 
ATOM   4315 C  CD2 . LEU   B 1 299 ? -32.39465 -23.20792 -63.34620 1.000 32.93384 ? 299 LEU   B CD2 1 
ATOM   4316 N  N   . LEU   B 1 300 ? -29.83204 -19.66052 -61.01054 1.000 30.78703 ? 300 LEU   B N   1 
ATOM   4317 C  CA  . LEU   B 1 300 ? -29.25817 -19.00645 -59.84123 1.000 35.34393 ? 300 LEU   B CA  1 
ATOM   4318 C  C   . LEU   B 1 300 ? -30.18131 -19.25186 -58.65885 1.000 30.12363 ? 300 LEU   B C   1 
ATOM   4319 O  O   . LEU   B 1 300 ? -31.37487 -18.94421 -58.73379 1.000 41.38008 ? 300 LEU   B O   1 
ATOM   4320 C  CB  . LEU   B 1 300 ? -29.10658 -17.50034 -60.06300 1.000 30.43889 ? 300 LEU   B CB  1 
ATOM   4321 C  CG  . LEU   B 1 300 ? -28.65086 -17.01715 -61.43281 1.000 29.61311 ? 300 LEU   B CG  1 
ATOM   4322 C  CD1 . LEU   B 1 300 ? -29.06597 -15.55626 -61.64221 1.000 39.21205 ? 300 LEU   B CD1 1 
ATOM   4323 C  CD2 . LEU   B 1 300 ? -27.13994 -17.19735 -61.55700 1.000 33.22911 ? 300 LEU   B CD2 1 
ATOM   4324 N  N   . ASP   B 1 301 ? -29.63926 -19.78327 -57.56379 1.000 33.94094 ? 301 ASP   B N   1 
ATOM   4325 C  CA  . ASP   B 1 301 ? -30.49336 -20.16850 -56.44550 1.000 35.17774 ? 301 ASP   B CA  1 
ATOM   4326 C  C   . ASP   B 1 301 ? -30.55407 -19.12412 -55.33611 1.000 35.68197 ? 301 ASP   B C   1 
ATOM   4327 O  O   . ASP   B 1 301 ? -31.64824 -18.77393 -54.88535 1.000 41.60626 ? 301 ASP   B O   1 
ATOM   4328 C  CB  . ASP   B 1 301 ? -30.04556 -21.51091 -55.85824 1.000 33.23530 ? 301 ASP   B CB  1 
ATOM   4329 C  CG  . ASP   B 1 301 ? -31.12151 -22.14671 -55.00123 1.000 27.77846 ? 301 ASP   B CG  1 
ATOM   4330 O  OD1 . ASP   B 1 301 ? -32.28963 -22.17104 -55.44764 1.000 25.86953 ? 301 ASP   B OD1 1 
ATOM   4331 O  OD2 . ASP   B 1 301 ? -30.80913 -22.60640 -53.88283 1.000 28.43438 ? 301 ASP   B OD2 1 
ATOM   4332 N  N   . ASN   B 1 302 ? -29.41303 -18.62728 -54.87144 1.000 37.51532 ? 302 ASN   B N   1 
ATOM   4333 C  CA  . ASN   B 1 302 ? -29.39218 -17.73426 -53.72201 1.000 39.80834 ? 302 ASN   B CA  1 
ATOM   4334 C  C   . ASN   B 1 302 ? -29.30970 -16.27392 -54.15361 1.000 34.92654 ? 302 ASN   B C   1 
ATOM   4335 O  O   . ASN   B 1 302 ? -28.89967 -15.94830 -55.27080 1.000 33.17429 ? 302 ASN   B O   1 
ATOM   4336 C  CB  . ASN   B 1 302 ? -28.22588 -18.07167 -52.78649 1.000 37.91160 ? 302 ASN   B CB  1 
ATOM   4337 C  CG  . ASN   B 1 302 ? -26.87949 -18.00558 -53.47947 1.000 42.76236 ? 302 ASN   B CG  1 
ATOM   4338 O  OD1 . ASN   B 1 302 ? -26.38627 -16.92620 -53.80297 1.000 44.72781 ? 302 ASN   B OD1 1 
ATOM   4339 N  ND2 . ASN   B 1 302 ? -26.27199 -19.16496 -53.70175 1.000 43.31175 ? 302 ASN   B ND2 1 
ATOM   4340 N  N   . TYR   B 1 303 ? -29.71358 -15.39208 -53.23352 1.000 35.79163 ? 303 TYR   B N   1 
ATOM   4341 C  CA  . TYR   B 1 303 ? -29.67248 -13.95566 -53.49122 1.000 32.57908 ? 303 TYR   B CA  1 
ATOM   4342 C  C   . TYR   B 1 303 ? -28.26854 -13.48997 -53.84793 1.000 30.55925 ? 303 TYR   B C   1 
ATOM   4343 O  O   . TYR   B 1 303 ? -28.09715 -12.61017 -54.69970 1.000 32.62652 ? 303 TYR   B O   1 
ATOM   4344 C  CB  . TYR   B 1 303 ? -30.18451 -13.19162 -52.26808 1.000 30.89295 ? 303 TYR   B CB  1 
ATOM   4345 C  CG  . TYR   B 1 303 ? -29.99225 -11.69055 -52.34504 1.000 29.45301 ? 303 TYR   B CG  1 
ATOM   4346 C  CD1 . TYR   B 1 303 ? -30.92533 -10.88362 -52.98199 1.000 29.68488 ? 303 TYR   B CD1 1 
ATOM   4347 C  CD2 . TYR   B 1 303 ? -28.88046 -11.08003 -51.77261 1.000 26.87835 ? 303 TYR   B CD2 1 
ATOM   4348 C  CE1 . TYR   B 1 303 ? -30.75600 -9.51269  -53.05191 1.000 29.59224 ? 303 TYR   B CE1 1 
ATOM   4349 C  CE2 . TYR   B 1 303 ? -28.70170 -9.71099  -51.83945 1.000 30.24298 ? 303 TYR   B CE2 1 
ATOM   4350 C  CZ  . TYR   B 1 303 ? -29.64265 -8.93217  -52.47881 1.000 32.92117 ? 303 TYR   B CZ  1 
ATOM   4351 O  OH  . TYR   B 1 303 ? -29.46800 -7.56862  -52.54494 1.000 31.27030 ? 303 TYR   B OH  1 
ATOM   4352 N  N   . SER   B 1 304 ? -27.25208 -14.06682 -53.19927 1.000 29.58436 ? 304 SER   B N   1 
ATOM   4353 C  CA  . SER   B 1 304 ? -25.88034 -13.60553 -53.39342 1.000 36.35261 ? 304 SER   B CA  1 
ATOM   4354 C  C   . SER   B 1 304 ? -25.47526 -13.65695 -54.86076 1.000 37.82756 ? 304 SER   B C   1 
ATOM   4355 O  O   . SER   B 1 304 ? -24.78242 -12.75861 -55.35220 1.000 33.87953 ? 304 SER   B O   1 
ATOM   4356 C  CB  . SER   B 1 304 ? -24.92251 -14.43911 -52.54216 1.000 35.73035 ? 304 SER   B CB  1 
ATOM   4357 O  OG  . SER   B 1 304 ? -23.57405 -14.08691 -52.79609 1.000 43.21577 ? 304 SER   B OG  1 
ATOM   4358 N  N   . ASP   B 1 305 ? -25.90568 -14.69250 -55.58132 1.000 33.95925 ? 305 ASP   B N   1 
ATOM   4359 C  CA  . ASP   B 1 305 ? -25.58155 -14.77320 -56.99943 1.000 33.42668 ? 305 ASP   B CA  1 
ATOM   4360 C  C   . ASP   B 1 305 ? -26.52329 -13.93185 -57.85316 1.000 31.46578 ? 305 ASP   B C   1 
ATOM   4361 O  O   . ASP   B 1 305 ? -26.09064 -13.36697 -58.86346 1.000 30.99161 ? 305 ASP   B O   1 
ATOM   4362 C  CB  . ASP   B 1 305 ? -25.59948 -16.23070 -57.46456 1.000 36.79229 ? 305 ASP   B CB  1 
ATOM   4363 C  CG  . ASP   B 1 305 ? -24.51361 -17.06474 -56.80909 1.000 42.64825 ? 305 ASP   B CG  1 
ATOM   4364 O  OD1 . ASP   B 1 305 ? -23.60276 -16.47660 -56.18798 1.000 47.71765 ? 305 ASP   B OD1 1 
ATOM   4365 O  OD2 . ASP   B 1 305 ? -24.56628 -18.30756 -56.92050 1.000 47.10419 ? 305 ASP   B OD2 1 
ATOM   4366 N  N   . ARG   B 1 306 ? -27.79774 -13.82000 -57.46602 1.000 26.38038 ? 306 ARG   B N   1 
ATOM   4367 C  CA  . ARG   B 1 306 ? -28.74496 -13.06200 -58.28004 1.000 30.10121 ? 306 ARG   B CA  1 
ATOM   4368 C  C   . ARG   B 1 306 ? -28.47169 -11.56413 -58.21045 1.000 33.16706 ? 306 ARG   B C   1 
ATOM   4369 O  O   . ARG   B 1 306 ? -28.54481 -10.86990 -59.23105 1.000 29.29848 ? 306 ARG   B O   1 
ATOM   4370 C  CB  . ARG   B 1 306 ? -30.18092 -13.36247 -57.85026 1.000 31.64366 ? 306 ARG   B CB  1 
ATOM   4371 C  CG  . ARG   B 1 306 ? -30.66273 -14.74368 -58.25467 1.000 36.92457 ? 306 ARG   B CG  1 
ATOM   4372 C  CD  . ARG   B 1 306 ? -32.17698 -14.79532 -58.47112 1.000 36.35669 ? 306 ARG   B CD  1 
ATOM   4373 N  NE  . ARG   B 1 306 ? -32.96870 -14.34113 -57.32470 1.000 39.04162 ? 306 ARG   B NE  1 
ATOM   4374 C  CZ  . ARG   B 1 306 ? -32.91557 -14.85311 -56.09551 1.000 40.62648 ? 306 ARG   B CZ  1 
ATOM   4375 N  NH1 . ARG   B 1 306 ? -32.09857 -15.85802 -55.80563 1.000 42.27145 ? 306 ARG   B NH1 1 
ATOM   4376 N  NH2 . ARG   B 1 306 ? -33.69146 -14.35251 -55.14320 1.000 43.35251 ? 306 ARG   B NH2 1 
ATOM   4377 N  N   . ILE   B 1 307 ? -28.16769 -11.04128 -57.01948 1.000 29.07004 ? 307 ILE   B N   1 
ATOM   4378 C  CA  . ILE   B 1 307 ? -27.84726 -9.62033  -56.92239 1.000 24.99609 ? 307 ILE   B CA  1 
ATOM   4379 C  C   . ILE   B 1 307 ? -26.54674 -9.32280  -57.65011 1.000 24.24274 ? 307 ILE   B C   1 
ATOM   4380 O  O   . ILE   B 1 307 ? -26.36557 -8.23116  -58.20260 1.000 27.17482 ? 307 ILE   B O   1 
ATOM   4381 C  CB  . ILE   B 1 307 ? -27.78288 -9.16850  -55.45066 1.000 25.39587 ? 307 ILE   B CB  1 
ATOM   4382 C  CG1 . ILE   B 1 307 ? -27.81262 -7.64223  -55.36870 1.000 22.94546 ? 307 ILE   B CG1 1 
ATOM   4383 C  CG2 . ILE   B 1 307 ? -26.53282 -9.70286  -54.76217 1.000 23.40650 ? 307 ILE   B CG2 1 
ATOM   4384 C  CD1 . ILE   B 1 307 ? -29.08085 -7.03216  -55.91813 1.000 20.49415 ? 307 ILE   B CD1 1 
ATOM   4385 N  N   . GLN   B 1 308 ? -25.63581 -10.29182 -57.68561 1.000 26.14458 ? 308 GLN   B N   1 
ATOM   4386 C  CA  . GLN   B 1 308 ? -24.34359 -10.08584 -58.31929 1.000 26.20468 ? 308 GLN   B CA  1 
ATOM   4387 C  C   . GLN   B 1 308 ? -24.46072 -10.07715 -59.83834 1.000 27.64246 ? 308 GLN   B C   1 
ATOM   4388 O  O   . GLN   B 1 308 ? -23.69936 -9.37586  -60.51593 1.000 25.16896 ? 308 GLN   B O   1 
ATOM   4389 C  CB  . GLN   B 1 308 ? -23.38847 -11.16698 -57.83004 1.000 33.07408 ? 308 GLN   B CB  1 
ATOM   4390 C  CG  . GLN   B 1 308 ? -22.31100 -11.54684 -58.79070 1.000 33.99031 ? 308 GLN   B CG  1 
ATOM   4391 C  CD  . GLN   B 1 308 ? -21.34312 -12.50463 -58.16719 1.000 41.64147 ? 308 GLN   B CD  1 
ATOM   4392 O  OE1 . GLN   B 1 308 ? -20.28590 -12.77473 -58.71875 1.000 47.71934 ? 308 GLN   B OE1 1 
ATOM   4393 N  NE2 . GLN   B 1 308 ? -21.69701 -13.01649 -56.99183 1.000 41.83291 ? 308 GLN   B NE2 1 
ATOM   4394 N  N   . VAL   B 1 309 ? -25.41032 -10.83644 -60.38858 1.000 22.32361 ? 309 VAL   B N   1 
ATOM   4395 C  CA  . VAL   B 1 309 ? -25.71477 -10.72185 -61.81106 1.000 25.93594 ? 309 VAL   B CA  1 
ATOM   4396 C  C   . VAL   B 1 309 ? -26.36378 -9.37557  -62.10538 1.000 24.82278 ? 309 VAL   B C   1 
ATOM   4397 O  O   . VAL   B 1 309 ? -26.07366 -8.74109  -63.12677 1.000 22.20604 ? 309 VAL   B O   1 
ATOM   4398 C  CB  . VAL   B 1 309 ? -26.60656 -11.89191 -62.26667 1.000 21.81310 ? 309 VAL   B CB  1 
ATOM   4399 C  CG1 . VAL   B 1 309 ? -27.07854 -11.68426 -63.69510 1.000 20.97328 ? 309 VAL   B CG1 1 
ATOM   4400 C  CG2 . VAL   B 1 309 ? -25.85948 -13.19798 -62.15609 1.000 22.01948 ? 309 VAL   B CG2 1 
ATOM   4401 N  N   . LEU   B 1 310 ? -27.24876 -8.91481  -61.21646 1.000 20.08083 ? 310 LEU   B N   1 
ATOM   4402 C  CA  . LEU   B 1 310 ? -27.86825 -7.60703  -61.40633 1.000 21.30720 ? 310 LEU   B CA  1 
ATOM   4403 C  C   . LEU   B 1 310 ? -26.86757 -6.47595  -61.20824 1.000 17.55956 ? 310 LEU   B C   1 
ATOM   4404 O  O   . LEU   B 1 310 ? -26.98407 -5.42896  -61.85517 1.000 19.32719 ? 310 LEU   B O   1 
ATOM   4405 C  CB  . LEU   B 1 310 ? -29.05514 -7.43700  -60.45830 1.000 24.62689 ? 310 LEU   B CB  1 
ATOM   4406 C  CG  . LEU   B 1 310 ? -30.27493 -8.31513  -60.73908 1.000 31.29161 ? 310 LEU   B CG  1 
ATOM   4407 C  CD1 . LEU   B 1 310 ? -31.38067 -8.03435  -59.73428 1.000 29.06209 ? 310 LEU   B CD1 1 
ATOM   4408 C  CD2 . LEU   B 1 310 ? -30.77110 -8.10182  -62.15997 1.000 23.49706 ? 310 LEU   B CD2 1 
ATOM   4409 N  N   . GLN   B 1 311 ? -25.89032 -6.65939  -60.31773 1.000 18.96714 ? 311 GLN   B N   1 
ATOM   4410 C  CA  . GLN   B 1 311 ? -24.81390 -5.68217  -60.18866 1.000 20.48721 ? 311 GLN   B CA  1 
ATOM   4411 C  C   . GLN   B 1 311 ? -23.99427 -5.60337  -61.46905 1.000 22.07062 ? 311 GLN   B C   1 
ATOM   4412 O  O   . GLN   B 1 311 ? -23.74487 -4.51206  -61.99418 1.000 19.17633 ? 311 GLN   B O   1 
ATOM   4413 C  CB  . GLN   B 1 311 ? -23.91363 -6.03945  -59.00728 1.000 19.02513 ? 311 GLN   B CB  1 
ATOM   4414 C  CG  . GLN   B 1 311 ? -24.50144 -5.73614  -57.64549 1.000 16.15968 ? 311 GLN   B CG  1 
ATOM   4415 C  CD  . GLN   B 1 311 ? -23.67741 -6.33477  -56.52500 1.000 18.48637 ? 311 GLN   B CD  1 
ATOM   4416 O  OE1 . GLN   B 1 311 ? -23.17659 -7.45359  -56.63879 1.000 20.69797 ? 311 GLN   B OE1 1 
ATOM   4417 N  NE2 . GLN   B 1 311 ? -23.52549 -5.58957  -55.43727 1.000 18.64467 ? 311 GLN   B NE2 1 
ATOM   4418 N  N   . ASN   B 1 312 ? -23.55873 -6.75662  -61.98180 1.000 18.70508 ? 312 ASN   B N   1 
ATOM   4419 C  CA  . ASN   B 1 312 ? -22.76823 -6.76873  -63.20669 1.000 21.00519 ? 312 ASN   B CA  1 
ATOM   4420 C  C   . ASN   B 1 312 ? -23.59744 -6.35357  -64.41529 1.000 22.47848 ? 312 ASN   B C   1 
ATOM   4421 O  O   . ASN   B 1 312 ? -23.05101 -5.79790  -65.37411 1.000 25.13844 ? 312 ASN   B O   1 
ATOM   4422 C  CB  . ASN   B 1 312 ? -22.15686 -8.15445  -63.42560 1.000 19.64961 ? 312 ASN   B CB  1 
ATOM   4423 C  CG  . ASN   B 1 312 ? -20.93977 -8.40457  -62.54948 1.000 20.83913 ? 312 ASN   B CG  1 
ATOM   4424 O  OD1 . ASN   B 1 312 ? -19.81991 -8.02916  -62.89855 1.000 26.31942 ? 312 ASN   B OD1 1 
ATOM   4425 N  ND2 . ASN   B 1 312 ? -21.15574 -9.04295  -61.40504 1.000 28.00203 ? 312 ASN   B ND2 1 
ATOM   4426 N  N   . MET   B 1 313 ? -24.90954 -6.60115  -64.38927 1.000 19.49473 ? 313 MET   B N   1 
ATOM   4427 C  CA  . MET   B 1 313 ? -25.75594 -6.19684  -65.50809 1.000 20.74394 ? 313 MET   B CA  1 
ATOM   4428 C  C   . MET   B 1 313 ? -25.82335 -4.67966  -65.62729 1.000 21.44040 ? 313 MET   B C   1 
ATOM   4429 O  O   . MET   B 1 313 ? -25.57409 -4.11998  -66.70126 1.000 19.56635 ? 313 MET   B O   1 
ATOM   4430 C  CB  . MET   B 1 313 ? -27.15834 -6.78080  -65.35206 1.000 21.01911 ? 313 MET   B CB  1 
ATOM   4431 C  CG  . MET   B 1 313 ? -28.15293 -6.23701  -66.35872 1.000 18.53810 ? 313 MET   B CG  1 
ATOM   4432 S  SD  . MET   B 1 313 ? -29.81292 -6.87171  -66.08769 1.000 25.39080 ? 313 MET   B SD  1 
ATOM   4433 C  CE  . MET   B 1 313 ? -29.50915 -8.63583  -66.11403 1.000 19.34688 ? 313 MET   B CE  1 
ATOM   4434 N  N   . VAL   B 1 314 ? -26.17262 -3.99582  -64.53478 1.000 18.88570 ? 314 VAL   B N   1 
ATOM   4435 C  CA  . VAL   B 1 314 ? -26.20682 -2.53688  -64.55976 1.000 14.59696 ? 314 VAL   B CA  1 
ATOM   4436 C  C   . VAL   B 1 314 ? -24.80808 -1.97745  -64.77012 1.000 16.13658 ? 314 VAL   B C   1 
ATOM   4437 O  O   . VAL   B 1 314 ? -24.63419 -0.94053  -65.42287 1.000 16.69622 ? 314 VAL   B O   1 
ATOM   4438 C  CB  . VAL   B 1 314 ? -26.85391 -1.99796  -63.26879 1.000 12.86735 ? 314 VAL   B CB  1 
ATOM   4439 C  CG1 . VAL   B 1 314 ? -26.82870 -0.47807  -63.24938 1.000 10.23938 ? 314 VAL   B CG1 1 
ATOM   4440 C  CG2 . VAL   B 1 314 ? -28.28205 -2.50745  -63.14727 1.000 17.07399 ? 314 VAL   B CG2 1 
ATOM   4441 N  N   . HIS   B 1 315 ? -23.79079 -2.65571  -64.23588 1.000 15.02978 ? 315 HIS   B N   1 
ATOM   4442 C  CA  . HIS   B 1 315 ? -22.41090 -2.26660  -64.50561 1.000 14.62316 ? 315 HIS   B CA  1 
ATOM   4443 C  C   . HIS   B 1 315 ? -22.10301 -2.35979  -65.99534 1.000 21.00688 ? 315 HIS   B C   1 
ATOM   4444 O  O   . HIS   B 1 315 ? -21.47913 -1.46012  -66.57093 1.000 17.90645 ? 315 HIS   B O   1 
ATOM   4445 C  CB  . HIS   B 1 315 ? -21.45992 -3.14720  -63.69459 1.000 13.27789 ? 315 HIS   B CB  1 
ATOM   4446 C  CG  . HIS   B 1 315 ? -20.01672 -2.78022  -63.83982 1.000 17.03821 ? 315 HIS   B CG  1 
ATOM   4447 N  ND1 . HIS   B 1 315 ? -19.56350 -1.48301  -63.73372 1.000 15.47779 ? 315 HIS   B ND1 1 
ATOM   4448 C  CD2 . HIS   B 1 315 ? -18.92214 -3.54394  -64.06691 1.000 14.89389 ? 315 HIS   B CD2 1 
ATOM   4449 C  CE1 . HIS   B 1 315 ? -18.25294 -1.46227  -63.89777 1.000 12.41556 ? 315 HIS   B CE1 1 
ATOM   4450 N  NE2 . HIS   B 1 315 ? -17.83936 -2.69974  -64.10252 1.000 17.65391 ? 315 HIS   B NE2 1 
ATOM   4451 N  N   . CYS   B 1 316 ? -22.53927 -3.44739  -66.63751 1.000 14.24428 ? 316 CYS   B N   1 
ATOM   4452 C  CA  . CYS   B 1 316 ? -22.38061 -3.57441  -68.08334 1.000 15.60761 ? 316 CYS   B CA  1 
ATOM   4453 C  C   . CYS   B 1 316 ? -23.12754 -2.46609  -68.81366 1.000 20.39357 ? 316 CYS   B C   1 
ATOM   4454 O  O   . CYS   B 1 316 ? -22.59891 -1.85824  -69.75131 1.000 15.37617 ? 316 CYS   B O   1 
ATOM   4455 C  CB  . CYS   B 1 316 ? -22.87046 -4.94670  -68.55084 1.000 17.08781 ? 316 CYS   B CB  1 
ATOM   4456 S  SG  . CYS   B 1 316 ? -21.76593 -6.32730  -68.18500 1.000 18.56932 ? 316 CYS   B SG  1 
ATOM   4457 N  N   . ALA   B 1 317 ? -24.36744 -2.19347  -68.39804 1.000 15.92908 ? 317 ALA   B N   1 
ATOM   4458 C  CA  . ALA   B 1 317 ? -25.13310 -1.11474  -69.01379 1.000 18.39882 ? 317 ALA   B CA  1 
ATOM   4459 C  C   . ALA   B 1 317 ? -24.44454 0.22767   -68.81272 1.000 18.06736 ? 317 ALA   B C   1 
ATOM   4460 O  O   . ALA   B 1 317 ? -24.45980 1.08432   -69.70432 1.000 17.81997 ? 317 ALA   B O   1 
ATOM   4461 C  CB  . ALA   B 1 317 ? -26.54936 -1.08433  -68.44074 1.000 19.13749 ? 317 ALA   B CB  1 
ATOM   4462 N  N   . ASP   B 1 318 ? -23.83437 0.42612   -67.64347 1.000 16.55322 ? 318 ASP   B N   1 
ATOM   4463 C  CA  . ASP   B 1 318 ? -23.05928 1.63696   -67.40315 1.000 16.53332 ? 318 ASP   B CA  1 
ATOM   4464 C  C   . ASP   B 1 318 ? -21.87020 1.72225   -68.35293 1.000 16.66343 ? 318 ASP   B C   1 
ATOM   4465 O  O   . ASP   B 1 318 ? -21.49127 2.81482   -68.79153 1.000 15.85092 ? 318 ASP   B O   1 
ATOM   4466 C  CB  . ASP   B 1 318 ? -22.59587 1.66575   -65.94656 1.000 15.66346 ? 318 ASP   B CB  1 
ATOM   4467 C  CG  . ASP   B 1 318 ? -22.23778 3.05687   -65.47331 1.000 15.86237 ? 318 ASP   B CG  1 
ATOM   4468 O  OD1 . ASP   B 1 318 ? -22.84767 4.02753   -65.96513 1.000 11.30951 ? 318 ASP   B OD1 1 
ATOM   4469 O  OD2 . ASP   B 1 318 ? -21.34909 3.17770   -64.60372 1.000 18.65883 ? 318 ASP   B OD2 1 
ATOM   4470 N  N   . LEU   B 1 319 ? -21.27926 0.57772   -68.69241 1.000 15.75405 ? 319 LEU   B N   1 
ATOM   4471 C  CA  . LEU   B 1 319 ? -20.12190 0.49913   -69.57763 1.000 15.44060 ? 319 LEU   B CA  1 
ATOM   4472 C  C   . LEU   B 1 319 ? -20.49866 -0.04359  -70.95371 1.000 15.25025 ? 319 LEU   B C   1 
ATOM   4473 O  O   . LEU   B 1 319 ? -19.75768 -0.82614  -71.55168 1.000 17.37045 ? 319 LEU   B O   1 
ATOM   4474 C  CB  . LEU   B 1 319 ? -19.02897 -0.36579  -68.95672 1.000 11.76069 ? 319 LEU   B CB  1 
ATOM   4475 C  CG  . LEU   B 1 319 ? -18.48098 0.08267   -67.60293 1.000 18.11189 ? 319 LEU   B CG  1 
ATOM   4476 C  CD1 . LEU   B 1 319 ? -17.33561 -0.81698  -67.17258 1.000 12.40251 ? 319 LEU   B CD1 1 
ATOM   4477 C  CD2 . LEU   B 1 319 ? -18.03302 1.53110   -67.67198 1.000 16.74211 ? 319 LEU   B CD2 1 
ATOM   4478 N  N   . SER   B 1 320 ? -21.65242 0.36698   -71.47648 1.000 13.53139 ? 320 SER   B N   1 
ATOM   4479 C  CA  . SER   B 1 320 ? -22.16214 -0.17316  -72.72942 1.000 16.75529 ? 320 SER   B CA  1 
ATOM   4480 C  C   . SER   B 1 320 ? -21.95054 0.75116   -73.92218 1.000 21.43090 ? 320 SER   B C   1 
ATOM   4481 O  O   . SER   B 1 320 ? -22.25475 0.35007   -75.05008 1.000 17.98286 ? 320 SER   B O   1 
ATOM   4482 C  CB  . SER   B 1 320 ? -23.65345 -0.50145  -72.59733 1.000 16.38482 ? 320 SER   B CB  1 
ATOM   4483 O  OG  . SER   B 1 320 ? -24.42368 0.67760   -72.45047 1.000 19.76421 ? 320 SER   B OG  1 
ATOM   4484 N  N   . ASN   B 1 321 ? -21.44421 1.96879   -73.70947 1.000 18.07908 ? 321 ASN   B N   1 
ATOM   4485 C  CA  . ASN   B 1 321 ? -21.18876 2.87858   -74.82751 1.000 19.65687 ? 321 ASN   B CA  1 
ATOM   4486 C  C   . ASN   B 1 321 ? -20.35144 2.25194   -75.93623 1.000 15.26405 ? 321 ASN   B C   1 
ATOM   4487 O  O   . ASN   B 1 321 ? -20.75140 2.35441   -77.10686 1.000 18.51352 ? 321 ASN   B O   1 
ATOM   4488 C  CB  . ASN   B 1 321 ? -20.52211 4.17233   -74.33418 1.000 15.18760 ? 321 ASN   B CB  1 
ATOM   4489 C  CG  . ASN   B 1 321 ? -21.39224 4.95631   -73.37934 1.000 20.54466 ? 321 ASN   B CG  1 
ATOM   4490 O  OD1 . ASN   B 1 321 ? -20.90146 5.80247   -72.63252 1.000 17.40438 ? 321 ASN   B OD1 1 
ATOM   4491 N  ND2 . ASN   B 1 321 ? -22.68859 4.67083   -73.38526 1.000 16.52095 ? 321 ASN   B ND2 1 
ATOM   4492 N  N   . PRO   B 1 322 ? -19.21145 1.60251   -75.66565 1.000 13.29733 ? 322 PRO   B N   1 
ATOM   4493 C  CA  . PRO   B 1 322 ? -18.42913 1.02738   -76.77105 1.000 15.11683 ? 322 PRO   B CA  1 
ATOM   4494 C  C   . PRO   B 1 322 ? -19.08656 -0.16884  -77.44666 1.000 19.45958 ? 322 PRO   B C   1 
ATOM   4495 O  O   . PRO   B 1 322 ? -18.56258 -0.63531  -78.46645 1.000 18.08342 ? 322 PRO   B O   1 
ATOM   4496 C  CB  . PRO   B 1 322 ? -17.10824 0.62784   -76.09709 1.000 16.72210 ? 322 PRO   B CB  1 
ATOM   4497 C  CG  . PRO   B 1 322 ? -17.05401 1.43542   -74.84324 1.000 17.30226 ? 322 PRO   B CG  1 
ATOM   4498 C  CD  . PRO   B 1 322 ? -18.47426 1.50495   -74.39235 1.000 16.10851 ? 322 PRO   B CD  1 
ATOM   4499 N  N   . THR   B 1 323 ? -20.20258 -0.67937  -76.92743 1.000 18.68435 ? 323 THR   B N   1 
ATOM   4500 C  CA  . THR   B 1 323 ? -20.92589 -1.77007  -77.56895 1.000 21.47397 ? 323 THR   B CA  1 
ATOM   4501 C  C   . THR   B 1 323 ? -22.09369 -1.28729  -78.41775 1.000 20.19049 ? 323 THR   B C   1 
ATOM   4502 O  O   . THR   B 1 323 ? -22.73715 -2.10386  -79.08371 1.000 20.88096 ? 323 THR   B O   1 
ATOM   4503 C  CB  . THR   B 1 323 ? -21.44209 -2.76226  -76.52201 1.000 19.03170 ? 323 THR   B CB  1 
ATOM   4504 O  OG1 . THR   B 1 323 ? -22.60050 -2.21924  -75.87611 1.000 17.23004 ? 323 THR   B OG1 1 
ATOM   4505 C  CG2 . THR   B 1 323 ? -20.37200 -3.04264  -75.48310 1.000 14.85910 ? 323 THR   B CG2 1 
ATOM   4506 N  N   . LYS   B 1 324 ? -22.38973 0.00579   -78.40156 1.000 18.70376 ? 324 LYS   B N   1 
ATOM   4507 C  CA  . LYS   B 1 324 ? -23.48308 0.55428   -79.18607 1.000 21.10517 ? 324 LYS   B CA  1 
ATOM   4508 C  C   . LYS   B 1 324 ? -23.00863 0.82575   -80.60845 1.000 23.33528 ? 324 LYS   B C   1 
ATOM   4509 O  O   . LYS   B 1 324 ? -21.80922 0.78808   -80.89183 1.000 20.43981 ? 324 LYS   B O   1 
ATOM   4510 C  CB  . LYS   B 1 324 ? -24.00639 1.82322   -78.51547 1.000 24.30174 ? 324 LYS   B CB  1 
ATOM   4511 C  CG  . LYS   B 1 324 ? -24.57441 1.60339   -77.11694 1.000 21.84261 ? 324 LYS   B CG  1 
ATOM   4512 C  CD  . LYS   B 1 324 ? -25.83706 0.75209   -77.14621 1.000 26.27196 ? 324 LYS   B CD  1 
ATOM   4513 C  CE  . LYS   B 1 324 ? -26.34823 0.46509   -75.73912 1.000 22.22649 ? 324 LYS   B CE  1 
ATOM   4514 N  NZ  . LYS   B 1 324 ? -26.88368 1.68804   -75.07403 1.000 19.22626 ? 324 LYS   B NZ  1 
ATOM   4515 N  N   . PRO   B 1 325 ? -23.93475 1.06443   -81.54107 1.000 27.02599 ? 325 PRO   B N   1 
ATOM   4516 C  CA  . PRO   B 1 325 ? -23.53115 1.48846   -82.88646 1.000 26.11075 ? 325 PRO   B CA  1 
ATOM   4517 C  C   . PRO   B 1 325 ? -22.59833 2.69083   -82.83351 1.000 25.30537 ? 325 PRO   B C   1 
ATOM   4518 O  O   . PRO   B 1 325 ? -22.71157 3.55370   -81.95980 1.000 21.82655 ? 325 PRO   B O   1 
ATOM   4519 C  CB  . PRO   B 1 325 ? -24.86306 1.82996   -83.56013 1.000 26.47919 ? 325 PRO   B CB  1 
ATOM   4520 C  CG  . PRO   B 1 325 ? -25.82836 0.89459   -82.91344 1.000 27.33111 ? 325 PRO   B CG  1 
ATOM   4521 C  CD  . PRO   B 1 325 ? -25.37355 0.74685   -81.47965 1.000 24.61937 ? 325 PRO   B CD  1 
ATOM   4522 N  N   . LEU   B 1 326 ? -21.67103 2.73374   -83.79464 1.000 20.77391 ? 326 LEU   B N   1 
ATOM   4523 C  CA  . LEU   B 1 326 ? -20.53726 3.65109   -83.71227 1.000 21.38502 ? 326 LEU   B CA  1 
ATOM   4524 C  C   . LEU   B 1 326 ? -20.98215 5.10555   -83.60631 1.000 20.27514 ? 326 LEU   B C   1 
ATOM   4525 O  O   . LEU   B 1 326 ? -20.36283 5.89534   -82.88390 1.000 20.94045 ? 326 LEU   B O   1 
ATOM   4526 C  CB  . LEU   B 1 326 ? -19.62329 3.45634   -84.92191 1.000 24.11396 ? 326 LEU   B CB  1 
ATOM   4527 C  CG  . LEU   B 1 326 ? -18.36564 4.32460   -84.98783 1.000 20.16031 ? 326 LEU   B CG  1 
ATOM   4528 C  CD1 . LEU   B 1 326 ? -17.50149 4.12393   -83.75239 1.000 17.13152 ? 326 LEU   B CD1 1 
ATOM   4529 C  CD2 . LEU   B 1 326 ? -17.58107 4.02288   -86.25451 1.000 21.46651 ? 326 LEU   B CD2 1 
ATOM   4530 N  N   . GLN   B 1 327 ? -22.05104 5.48382   -84.31381 1.000 21.08332 ? 327 GLN   B N   1 
ATOM   4531 C  CA  . GLN   B 1 327 ? -22.49328 6.87456   -84.25888 1.000 23.46070 ? 327 GLN   B CA  1 
ATOM   4532 C  C   . GLN   B 1 327 ? -22.97181 7.25157   -82.86148 1.000 25.18080 ? 327 GLN   B C   1 
ATOM   4533 O  O   . GLN   B 1 327 ? -22.82746 8.40721   -82.44750 1.000 21.22829 ? 327 GLN   B O   1 
ATOM   4534 C  CB  . GLN   B 1 327 ? -23.58970 7.13269   -85.29876 1.000 27.72715 ? 327 GLN   B CB  1 
ATOM   4535 C  CG  . GLN   B 1 327 ? -25.02349 6.93485   -84.80527 1.000 36.48113 ? 327 GLN   B CG  1 
ATOM   4536 C  CD  . GLN   B 1 327 ? -25.61019 5.59876   -85.21078 1.000 50.07722 ? 327 GLN   B CD  1 
ATOM   4537 O  OE1 . GLN   B 1 327 ? -25.03982 4.87776   -86.03160 1.000 48.28482 ? 327 GLN   B OE1 1 
ATOM   4538 N  NE2 . GLN   B 1 327 ? -26.75971 5.26231   -84.63541 1.000 40.59386 ? 327 GLN   B NE2 1 
ATOM   4539 N  N   . LEU   B 1 328 ? -23.53015 6.29347   -82.11792 1.000 22.14749 ? 328 LEU   B N   1 
ATOM   4540 C  CA  . LEU   B 1 328 ? -23.87851 6.54256   -80.72280 1.000 21.97608 ? 328 LEU   B CA  1 
ATOM   4541 C  C   . LEU   B 1 328 ? -22.63162 6.55030   -79.84932 1.000 20.51541 ? 328 LEU   B C   1 
ATOM   4542 O  O   . LEU   B 1 328 ? -22.44429 7.44749   -79.01889 1.000 19.78952 ? 328 LEU   B O   1 
ATOM   4543 C  CB  . LEU   B 1 328 ? -24.86437 5.48181   -80.23258 1.000 23.37521 ? 328 LEU   B CB  1 
ATOM   4544 C  CG  . LEU   B 1 328 ? -26.28377 5.50641   -80.79619 1.000 27.71410 ? 328 LEU   B CG  1 
ATOM   4545 C  CD1 . LEU   B 1 328 ? -26.96842 4.17350   -80.54621 1.000 29.78702 ? 328 LEU   B CD1 1 
ATOM   4546 C  CD2 . LEU   B 1 328 ? -27.07657 6.63886   -80.16969 1.000 29.14335 ? 328 LEU   B CD2 1 
ATOM   4547 N  N   . TYR   B 1 329 ? -21.77182 5.54484   -80.02890 1.000 14.98189 ? 329 TYR   B N   1 
ATOM   4548 C  CA  . TYR   B 1 329 ? -20.53019 5.43473   -79.26941 1.000 16.11952 ? 329 TYR   B CA  1 
ATOM   4549 C  C   . TYR   B 1 329 ? -19.70183 6.71225   -79.37054 1.000 21.92929 ? 329 TYR   B C   1 
ATOM   4550 O  O   . TYR   B 1 329 ? -19.20549 7.22692   -78.36169 1.000 18.69762 ? 329 TYR   B O   1 
ATOM   4551 C  CB  . TYR   B 1 329 ? -19.74997 4.21868   -79.78224 1.000 12.59580 ? 329 TYR   B CB  1 
ATOM   4552 C  CG  . TYR   B 1 329 ? -18.41799 3.91336   -79.12118 1.000 14.08635 ? 329 TYR   B CG  1 
ATOM   4553 C  CD1 . TYR   B 1 329 ? -18.04542 4.49581   -77.91419 1.000 16.82571 ? 329 TYR   B CD1 1 
ATOM   4554 C  CD2 . TYR   B 1 329 ? -17.52967 3.02837   -79.71862 1.000 14.78609 ? 329 TYR   B CD2 1 
ATOM   4555 C  CE1 . TYR   B 1 329 ? -16.82451 4.20957   -77.32943 1.000 13.97224 ? 329 TYR   B CE1 1 
ATOM   4556 C  CE2 . TYR   B 1 329 ? -16.31338 2.73323   -79.14099 1.000 15.26547 ? 329 TYR   B CE2 1 
ATOM   4557 C  CZ  . TYR   B 1 329 ? -15.96364 3.32704   -77.94847 1.000 14.23223 ? 329 TYR   B CZ  1 
ATOM   4558 O  OH  . TYR   B 1 329 ? -14.74884 3.03132   -77.37509 1.000 14.47486 ? 329 TYR   B OH  1 
ATOM   4559 N  N   . ARG   B 1 330 ? -19.55281 7.24839   -80.58345 1.000 17.04469 ? 330 ARG   B N   1 
ATOM   4560 C  CA  . ARG   B 1 330 ? -18.70534 8.42322   -80.75624 1.000 19.97210 ? 330 ARG   B CA  1 
ATOM   4561 C  C   . ARG   B 1 330 ? -19.28258 9.65307   -80.06888 1.000 17.24117 ? 330 ARG   B C   1 
ATOM   4562 O  O   . ARG   B 1 330 ? -18.52265 10.51275  -79.60897 1.000 18.27010 ? 330 ARG   B O   1 
ATOM   4563 C  CB  . ARG   B 1 330 ? -18.47852 8.69731   -82.24014 1.000 14.73104 ? 330 ARG   B CB  1 
ATOM   4564 C  CG  . ARG   B 1 330 ? -17.27059 7.97699   -82.79815 1.000 20.34622 ? 330 ARG   B CG  1 
ATOM   4565 C  CD  . ARG   B 1 330 ? -16.59688 8.80715   -83.86621 1.000 28.29516 ? 330 ARG   B CD  1 
ATOM   4566 N  NE  . ARG   B 1 330 ? -17.26821 8.67661   -85.15380 1.000 29.70128 ? 330 ARG   B NE  1 
ATOM   4567 C  CZ  . ARG   B 1 330 ? -16.95126 9.38784   -86.22896 1.000 34.01161 ? 330 ARG   B CZ  1 
ATOM   4568 N  NH1 . ARG   B 1 330 ? -15.97450 10.28204  -86.16236 1.000 24.47942 ? 330 ARG   B NH1 1 
ATOM   4569 N  NH2 . ARG   B 1 330 ? -17.60905 9.20776   -87.36701 1.000 28.19362 ? 330 ARG   B NH2 1 
ATOM   4570 N  N   . GLN   B 1 331 ? -20.61025 9.76043   -79.98670 1.000 15.97119 ? 331 GLN   B N   1 
ATOM   4571 C  CA  . GLN   B 1 331 ? -21.20261 10.86483  -79.23918 1.000 18.88605 ? 331 GLN   B CA  1 
ATOM   4572 C  C   . GLN   B 1 331 ? -20.94675 10.71365  -77.74570 1.000 18.44183 ? 331 GLN   B C   1 
ATOM   4573 O  O   . GLN   B 1 331 ? -20.72206 11.70731  -77.04483 1.000 15.70712 ? 331 GLN   B O   1 
ATOM   4574 C  CB  . GLN   B 1 331 ? -22.70100 10.95622  -79.52579 1.000 21.85915 ? 331 GLN   B CB  1 
ATOM   4575 C  CG  . GLN   B 1 331 ? -23.02993 11.17152  -80.99284 1.000 25.88515 ? 331 GLN   B CG  1 
ATOM   4576 C  CD  . GLN   B 1 331 ? -24.51407 11.34892  -81.24009 1.000 30.39818 ? 331 GLN   B CD  1 
ATOM   4577 O  OE1 . GLN   B 1 331 ? -25.14433 10.53659  -81.91685 1.000 35.94654 ? 331 GLN   B OE1 1 
ATOM   4578 N  NE2 . GLN   B 1 331 ? -25.07983 12.41981  -80.69754 1.000 30.97041 ? 331 GLN   B NE2 1 
ATOM   4579 N  N   . TRP   B 1 332 ? -20.97222 9.47825   -77.24092 1.000 16.91062 ? 332 TRP   B N   1 
ATOM   4580 C  CA  . TRP   B 1 332 ? -20.63318 9.25420   -75.84043 1.000 18.05644 ? 332 TRP   B CA  1 
ATOM   4581 C  C   . TRP   B 1 332 ? -19.17191 9.58445   -75.57129 1.000 17.04371 ? 332 TRP   B C   1 
ATOM   4582 O  O   . TRP   B 1 332 ? -18.83877 10.15289  -74.52465 1.000 19.43908 ? 332 TRP   B O   1 
ATOM   4583 C  CB  . TRP   B 1 332 ? -20.93718 7.80955   -75.44632 1.000 18.00595 ? 332 TRP   B CB  1 
ATOM   4584 C  CG  . TRP   B 1 332 ? -22.39822 7.49863   -75.38066 1.000 17.58804 ? 332 TRP   B CG  1 
ATOM   4585 C  CD1 . TRP   B 1 332 ? -23.06056 6.52273   -76.06624 1.000 19.89442 ? 332 TRP   B CD1 1 
ATOM   4586 C  CD2 . TRP   B 1 332 ? -23.38373 8.17354   -74.58951 1.000 17.43562 ? 332 TRP   B CD2 1 
ATOM   4587 N  NE1 . TRP   B 1 332 ? -24.39622 6.54323   -75.74590 1.000 20.16244 ? 332 TRP   B NE1 1 
ATOM   4588 C  CE2 . TRP   B 1 332 ? -24.62011 7.54830   -74.84202 1.000 15.31935 ? 332 TRP   B CE2 1 
ATOM   4589 C  CE3 . TRP   B 1 332 ? -23.33993 9.24345   -73.68933 1.000 14.56404 ? 332 TRP   B CE3 1 
ATOM   4590 C  CZ2 . TRP   B 1 332 ? -25.80123 7.95729   -74.22928 1.000 18.24752 ? 332 TRP   B CZ2 1 
ATOM   4591 C  CZ3 . TRP   B 1 332 ? -24.51329 9.64793   -73.08325 1.000 16.78257 ? 332 TRP   B CZ3 1 
ATOM   4592 C  CH2 . TRP   B 1 332 ? -25.72743 9.00694   -73.35527 1.000 20.90029 ? 332 TRP   B CH2 1 
ATOM   4593 N  N   . THR   B 1 333 ? -18.28548 9.23436   -76.50640 1.000 15.51713 ? 333 THR   B N   1 
ATOM   4594 C  CA  . THR   B 1 333 ? -16.86999 9.55070   -76.34671 1.000 18.72414 ? 333 THR   B CA  1 
ATOM   4595 C  C   . THR   B 1 333 ? -16.64976 11.05689  -76.30454 1.000 16.44045 ? 333 THR   B C   1 
ATOM   4596 O  O   . THR   B 1 333 ? -15.91585 11.56360  -75.44850 1.000 19.08804 ? 333 THR   B O   1 
ATOM   4597 C  CB  . THR   B 1 333 ? -16.05838 8.91940   -77.47809 1.000 15.40145 ? 333 THR   B CB  1 
ATOM   4598 O  OG1 . THR   B 1 333 ? -16.16177 7.49253   -77.40348 1.000 17.48186 ? 333 THR   B OG1 1 
ATOM   4599 C  CG2 . THR   B 1 333 ? -14.59620 9.31842   -77.37001 1.000 14.88462 ? 333 THR   B CG2 1 
ATOM   4600 N  N   . ASP   B 1 334 ? -17.28071 11.78953  -77.22707 1.000 20.17172 ? 334 ASP   B N   1 
ATOM   4601 C  CA  . ASP   B 1 334 ? -17.20766 13.24756  -77.20270 1.000 19.79557 ? 334 ASP   B CA  1 
ATOM   4602 C  C   . ASP   B 1 334 ? -17.64184 13.79540  -75.85021 1.000 21.82132 ? 334 ASP   B C   1 
ATOM   4603 O  O   . ASP   B 1 334 ? -16.99938 14.69063  -75.29062 1.000 19.63742 ? 334 ASP   B O   1 
ATOM   4604 C  CB  . ASP   B 1 334 ? -18.07725 13.84256  -78.31306 1.000 21.71556 ? 334 ASP   B CB  1 
ATOM   4605 C  CG  . ASP   B 1 334 ? -17.44842 13.71370  -79.68380 1.000 33.82288 ? 334 ASP   B CG  1 
ATOM   4606 O  OD1 . ASP   B 1 334 ? -16.27451 13.29660  -79.76402 1.000 31.34128 ? 334 ASP   B OD1 1 
ATOM   4607 O  OD2 . ASP   B 1 334 ? -18.12724 14.04198  -80.68048 1.000 26.59233 ? 334 ASP   B OD2 1 
ATOM   4608 N  N   . ARG   B 1 335 ? -18.73001 13.25475  -75.30267 1.000 17.08195 ? 335 ARG   B N   1 
ATOM   4609 C  CA  . ARG   B 1 335 ? -19.28837 13.80769  -74.07463 1.000 21.10146 ? 335 ARG   B CA  1 
ATOM   4610 C  C   . ARG   B 1 335 ? -18.40576 13.49863  -72.86915 1.000 19.40200 ? 335 ARG   B C   1 
ATOM   4611 O  O   . ARG   B 1 335 ? -18.14475 14.38006  -72.04169 1.000 17.72327 ? 335 ARG   B O   1 
ATOM   4612 C  CB  . ARG   B 1 335 ? -20.71320 13.28946  -73.87534 1.000 17.78059 ? 335 ARG   B CB  1 
ATOM   4613 C  CG  . ARG   B 1 335 ? -21.72630 13.99625  -74.77428 1.000 20.45680 ? 335 ARG   B CG  1 
ATOM   4614 C  CD  . ARG   B 1 335 ? -23.07720 13.29773  -74.80636 1.000 21.13935 ? 335 ARG   B CD  1 
ATOM   4615 N  NE  . ARG   B 1 335 ? -24.08007 14.09139  -75.51437 1.000 21.28878 ? 335 ARG   B NE  1 
ATOM   4616 C  CZ  . ARG   B 1 335 ? -24.79225 15.06509  -74.95542 1.000 23.40313 ? 335 ARG   B CZ  1 
ATOM   4617 N  NH1 . ARG   B 1 335 ? -24.61736 15.36554  -73.67548 1.000 20.74334 ? 335 ARG   B NH1 1 
ATOM   4618 N  NH2 . ARG   B 1 335 ? -25.68155 15.73725  -75.67397 1.000 25.85612 ? 335 ARG   B NH2 1 
ATOM   4619 N  N   . ILE   B 1 336 ? -17.92057 12.25867  -72.75562 1.000 19.47497 ? 336 ILE   B N   1 
ATOM   4620 C  CA  . ILE   B 1 336 ? -17.08740 11.91069  -71.60580 1.000 19.86591 ? 336 ILE   B CA  1 
ATOM   4621 C  C   . ILE   B 1 336 ? -15.75186 12.64408  -71.67017 1.000 17.98772 ? 336 ILE   B C   1 
ATOM   4622 O  O   . ILE   B 1 336 ? -15.20391 13.05185  -70.63886 1.000 17.61295 ? 336 ILE   B O   1 
ATOM   4623 C  CB  . ILE   B 1 336 ? -16.89870 10.38354  -71.50219 1.000 17.49799 ? 336 ILE   B CB  1 
ATOM   4624 C  CG1 . ILE   B 1 336 ? -16.33788 10.01069  -70.12764 1.000 17.85328 ? 336 ILE   B CG1 1 
ATOM   4625 C  CG2 . ILE   B 1 336 ? -15.97427 9.85891   -72.58991 1.000 17.42833 ? 336 ILE   B CG2 1 
ATOM   4626 C  CD1 . ILE   B 1 336 ? -17.33130 10.16438  -68.99736 1.000 18.75539 ? 336 ILE   B CD1 1 
ATOM   4627 N  N   . MET   B 1 337 ? -15.21053 12.83725  -72.87782 1.000 22.24830 ? 337 MET   B N   1 
ATOM   4628 C  CA  . MET   B 1 337 ? -13.95087 13.56502  -73.00200 1.000 18.57713 ? 337 MET   B CA  1 
ATOM   4629 C  C   . MET   B 1 337 ? -14.13762 15.03575  -72.65992 1.000 22.45332 ? 337 MET   B C   1 
ATOM   4630 O  O   . MET   B 1 337 ? -13.25814 15.65585  -72.05131 1.000 20.47586 ? 337 MET   B O   1 
ATOM   4631 C  CB  . MET   B 1 337 ? -13.37777 13.40813  -74.41111 1.000 20.99406 ? 337 MET   B CB  1 
ATOM   4632 C  CG  . MET   B 1 337 ? -12.88438 12.00620  -74.72702 1.000 24.35459 ? 337 MET   B CG  1 
ATOM   4633 S  SD  . MET   B 1 337 ? -11.84608 11.31861  -73.42169 1.000 23.56320 ? 337 MET   B SD  1 
ATOM   4634 C  CE  . MET   B 1 337 ? -10.46346 12.45411  -73.42667 1.000 27.34622 ? 337 MET   B CE  1 
ATOM   4635 N  N   . GLU   B 1 338 ? -15.28085 15.60557  -73.04466 1.000 17.51082 ? 338 GLU   B N   1 
ATOM   4636 C  CA  . GLU   B 1 338 ? -15.60588 16.97573  -72.66552 1.000 22.20579 ? 338 GLU   B CA  1 
ATOM   4637 C  C   . GLU   B 1 338 ? -15.71196 17.11415  -71.15208 1.000 24.33200 ? 338 GLU   B C   1 
ATOM   4638 O  O   . GLU   B 1 338 ? -15.22255 18.09138  -70.57239 1.000 20.10059 ? 338 GLU   B O   1 
ATOM   4639 C  CB  . GLU   B 1 338 ? -16.90773 17.38663  -73.35091 1.000 21.53986 ? 338 GLU   B CB  1 
ATOM   4640 C  CG  . GLU   B 1 338 ? -17.46548 18.74539  -72.99122 1.000 33.01781 ? 338 GLU   B CG  1 
ATOM   4641 C  CD  . GLU   B 1 338 ? -18.72351 19.02952  -73.78459 1.000 45.26095 ? 338 GLU   B CD  1 
ATOM   4642 O  OE1 . GLU   B 1 338 ? -19.00692 18.24322  -74.71091 1.000 56.20287 ? 338 GLU   B OE1 1 
ATOM   4643 O  OE2 . GLU   B 1 338 ? -19.42397 20.02042  -73.49476 1.000 49.68126 ? 338 GLU   B OE2 1 
ATOM   4644 N  N   . GLU   B 1 339 ? -16.32908 16.13031  -70.49293 1.000 18.70138 ? 339 GLU   B N   1 
ATOM   4645 C  CA  . GLU   B 1 339 ? -16.45474 16.17460  -69.03987 1.000 20.88892 ? 339 GLU   B CA  1 
ATOM   4646 C  C   . GLU   B 1 339 ? -15.10682 15.96756  -68.36117 1.000 19.12931 ? 339 GLU   B C   1 
ATOM   4647 O  O   . GLU   B 1 339 ? -14.78279 16.66475  -67.39257 1.000 23.43652 ? 339 GLU   B O   1 
ATOM   4648 C  CB  . GLU   B 1 339 ? -17.46150 15.12605  -68.56816 1.000 18.73505 ? 339 GLU   B CB  1 
ATOM   4649 C  CG  . GLU   B 1 339 ? -17.69304 15.11412  -67.06652 1.000 17.86368 ? 339 GLU   B CG  1 
ATOM   4650 C  CD  . GLU   B 1 339 ? -18.81338 14.17694  -66.66436 1.000 15.00831 ? 339 GLU   B CD  1 
ATOM   4651 O  OE1 . GLU   B 1 339 ? -19.81906 14.10446  -67.39995 1.000 14.56256 ? 339 GLU   B OE1 1 
ATOM   4652 O  OE2 . GLU   B 1 339 ? -18.68851 13.51119  -65.61601 1.000 14.60044 ? 339 GLU   B OE2 1 
ATOM   4653 N  N   . PHE   B 1 340 ? -14.31231 15.00963  -68.84774 1.000 18.49578 ? 340 PHE   B N   1 
ATOM   4654 C  CA  . PHE   B 1 340 ? -12.96118 14.83029  -68.32311 1.000 17.64528 ? 340 PHE   B CA  1 
ATOM   4655 C  C   . PHE   B 1 340 ? -12.14723 16.10872  -68.46931 1.000 24.28811 ? 340 PHE   B C   1 
ATOM   4656 O  O   . PHE   B 1 340 ? -11.47976 16.54740  -67.52543 1.000 25.13693 ? 340 PHE   B O   1 
ATOM   4657 C  CB  . PHE   B 1 340 ? -12.25275 13.68224  -69.04438 1.000 16.84173 ? 340 PHE   B CB  1 
ATOM   4658 C  CG  . PHE   B 1 340 ? -12.69564 12.31237  -68.61732 1.000 23.43798 ? 340 PHE   B CG  1 
ATOM   4659 C  CD1 . PHE   B 1 340 ? -13.66027 12.13879  -67.63867 1.000 21.85727 ? 340 PHE   B CD1 1 
ATOM   4660 C  CD2 . PHE   B 1 340 ? -12.13118 11.19049  -69.20213 1.000 25.94440 ? 340 PHE   B CD2 1 
ATOM   4661 C  CE1 . PHE   B 1 340 ? -14.05576 10.86727  -67.25826 1.000 28.23861 ? 340 PHE   B CE1 1 
ATOM   4662 C  CE2 . PHE   B 1 340 ? -12.51972 9.92146   -68.82771 1.000 24.41146 ? 340 PHE   B CE2 1 
ATOM   4663 C  CZ  . PHE   B 1 340 ? -13.48267 9.75753   -67.85534 1.000 21.95016 ? 340 PHE   B CZ  1 
ATOM   4664 N  N   . PHE   B 1 341 ? -12.19289 16.72003  -69.65617 1.000 23.27560 ? 341 PHE   B N   1 
ATOM   4665 C  CA  . PHE   B 1 341 ? -11.36093 17.88816  -69.92726 1.000 25.89918 ? 341 PHE   B CA  1 
ATOM   4666 C  C   . PHE   B 1 341 ? -11.71393 19.04819  -69.00966 1.000 23.87023 ? 341 PHE   B C   1 
ATOM   4667 O  O   . PHE   B 1 341 ? -10.83101 19.78609  -68.55871 1.000 24.68282 ? 341 PHE   B O   1 
ATOM   4668 C  CB  . PHE   B 1 341 ? -11.50013 18.30028  -71.39127 1.000 21.06594 ? 341 PHE   B CB  1 
ATOM   4669 C  CG  . PHE   B 1 341 ? -10.79069 17.38540  -72.34336 1.000 22.14825 ? 341 PHE   B CG  1 
ATOM   4670 C  CD1 . PHE   B 1 341 ? -9.81240  16.51599  -71.88826 1.000 23.02258 ? 341 PHE   B CD1 1 
ATOM   4671 C  CD2 . PHE   B 1 341 ? -11.09883 17.39420  -73.69174 1.000 19.28097 ? 341 PHE   B CD2 1 
ATOM   4672 C  CE1 . PHE   B 1 341 ? -9.15498  15.67412  -72.76037 1.000 22.54950 ? 341 PHE   B CE1 1 
ATOM   4673 C  CE2 . PHE   B 1 341 ? -10.44558 16.55410  -74.56924 1.000 18.47661 ? 341 PHE   B CE2 1 
ATOM   4674 C  CZ  . PHE   B 1 341 ? -9.47160  15.69419  -74.10332 1.000 23.14570 ? 341 PHE   B CZ  1 
ATOM   4675 N  N   . ARG   B 1 342 ? -12.99719 19.22242  -68.71293 1.000 25.97122 ? 342 ARG   B N   1 
ATOM   4676 C  CA  . ARG   B 1 342 ? -13.38220 20.30656  -67.82365 1.000 28.25163 ? 342 ARG   B CA  1 
ATOM   4677 C  C   . ARG   B 1 342 ? -12.98915 20.02084  -66.38417 1.000 29.74751 ? 342 ARG   B C   1 
ATOM   4678 O  O   . ARG   B 1 342 ? -12.77477 20.95679  -65.60541 1.000 26.50743 ? 342 ARG   B O   1 
ATOM   4679 C  CB  . ARG   B 1 342 ? -14.87467 20.54694  -67.91957 1.000 22.51128 ? 342 ARG   B CB  1 
ATOM   4680 C  CG  . ARG   B 1 342 ? -15.31403 21.09798  -69.23792 1.000 37.88306 ? 342 ARG   B CG  1 
ATOM   4681 C  CD  . ARG   B 1 342 ? -16.78607 21.32501  -69.14764 1.000 42.63773 ? 342 ARG   B CD  1 
ATOM   4682 N  NE  . ARG   B 1 342 ? -17.49016 21.21841  -70.41730 1.000 49.35632 ? 342 ARG   B NE  1 
ATOM   4683 C  CZ  . ARG   B 1 342 ? -18.81211 21.26556  -70.52168 1.000 49.12723 ? 342 ARG   B CZ  1 
ATOM   4684 N  NH1 . ARG   B 1 342 ? -19.54952 21.39898  -69.42843 1.000 46.23162 ? 342 ARG   B NH1 1 
ATOM   4685 N  NH2 . ARG   B 1 342 ? -19.38953 21.17657  -71.70843 1.000 53.92884 ? 342 ARG   B NH2 1 
ATOM   4686 N  N   . GLN   B 1 343 ? -12.90944 18.74635  -66.00272 1.000 25.71480 ? 343 GLN   B N   1 
ATOM   4687 C  CA  . GLN   B 1 343 ? -12.32976 18.42439  -64.70602 1.000 28.01921 ? 343 GLN   B CA  1 
ATOM   4688 C  C   . GLN   B 1 343 ? -10.85088 18.78315  -64.68047 1.000 26.96327 ? 343 GLN   B C   1 
ATOM   4689 O  O   . GLN   B 1 343 ? -10.36200 19.37655  -63.71239 1.000 27.03051 ? 343 GLN   B O   1 
ATOM   4690 C  CB  . GLN   B 1 343 ? -12.52936 16.94680  -64.37509 1.000 21.91364 ? 343 GLN   B CB  1 
ATOM   4691 C  CG  . GLN   B 1 343 ? -11.74083 16.51911  -63.14851 1.000 21.19630 ? 343 GLN   B CG  1 
ATOM   4692 C  CD  . GLN   B 1 343 ? -12.07727 15.12228  -62.67356 1.000 19.45492 ? 343 GLN   B CD  1 
ATOM   4693 O  OE1 . GLN   B 1 343 ? -13.21090 14.66105  -62.80360 1.000 17.71141 ? 343 GLN   B OE1 1 
ATOM   4694 N  NE2 . GLN   B 1 343 ? -11.08797 14.44049  -62.11117 1.000 18.44125 ? 343 GLN   B NE2 1 
ATOM   4695 N  N   . GLY   B 1 344 ? -10.12341 18.43523  -65.74531 1.000 27.72423 ? 344 GLY   B N   1 
ATOM   4696 C  CA  . GLY   B 1 344 ? -8.72728  18.82389  -65.83709 1.000 31.73303 ? 344 GLY   B CA  1 
ATOM   4697 C  C   . GLY   B 1 344 ? -8.53072  20.32593  -65.83589 1.000 33.49962 ? 344 GLY   B C   1 
ATOM   4698 O  O   . GLY   B 1 344 ? -7.51549  20.82237  -65.34058 1.000 31.22311 ? 344 GLY   B O   1 
ATOM   4699 N  N   . ASP   B 1 345 ? -9.49313  21.07054  -66.38631 1.000 34.42502 ? 345 ASP   B N   1 
ATOM   4700 C  CA  . ASP   B 1 345 ? -9.42705  22.52582  -66.30913 1.000 30.28505 ? 345 ASP   B CA  1 
ATOM   4701 C  C   . ASP   B 1 345 ? -9.57031  23.00468  -64.87199 1.000 43.91254 ? 345 ASP   B C   1 
ATOM   4702 O  O   . ASP   B 1 345 ? -8.84368  23.90554  -64.43736 1.000 38.94504 ? 345 ASP   B O   1 
ATOM   4703 C  CB  . ASP   B 1 345 ? -10.50262 23.15502  -67.19181 1.000 28.96612 ? 345 ASP   B CB  1 
ATOM   4704 C  CG  . ASP   B 1 345 ? -10.19362 23.01970  -68.66412 1.000 29.14375 ? 345 ASP   B CG  1 
ATOM   4705 O  OD1 . ASP   B 1 345 ? -9.09377  22.52924  -68.99389 1.000 26.12480 ? 345 ASP   B OD1 1 
ATOM   4706 O  OD2 . ASP   B 1 345 ? -11.04352 23.41294  -69.48953 1.000 30.10229 ? 345 ASP   B OD2 1 
ATOM   4707 N  N   . ARG   B 1 346 ? -10.50305 22.41563  -64.11968 1.000 38.11227 ? 346 ARG   B N   1 
ATOM   4708 C  CA  . ARG   B 1 346 ? -10.63479 22.76249  -62.70903 1.000 36.62704 ? 346 ARG   B CA  1 
ATOM   4709 C  C   . ARG   B 1 346 ? -9.40276  22.33352  -61.92334 1.000 36.35100 ? 346 ARG   B C   1 
ATOM   4710 O  O   . ARG   B 1 346 ? -8.97513  23.02927  -60.99526 1.000 40.95302 ? 346 ARG   B O   1 
ATOM   4711 C  CB  . ARG   B 1 346 ? -11.89542 22.12676  -62.12339 1.000 31.70539 ? 346 ARG   B CB  1 
ATOM   4712 C  CG  . ARG   B 1 346 ? -13.19431 22.69719  -62.66721 1.000 34.94716 ? 346 ARG   B CG  1 
ATOM   4713 C  CD  . ARG   B 1 346 ? -14.22167 22.82830  -61.55516 1.000 47.24912 ? 346 ARG   B CD  1 
ATOM   4714 N  NE  . ARG   B 1 346 ? -15.34631 21.91272  -61.71928 1.000 44.81341 ? 346 ARG   B NE  1 
ATOM   4715 C  CZ  . ARG   B 1 346 ? -16.10136 21.47341  -60.71744 1.000 46.72390 ? 346 ARG   B CZ  1 
ATOM   4716 N  NH1 . ARG   B 1 346 ? -15.84602 21.85724  -59.47347 1.000 45.09739 ? 346 ARG   B NH1 1 
ATOM   4717 N  NH2 . ARG   B 1 346 ? -17.10828 20.64498  -60.95768 1.000 41.40640 ? 346 ARG   B NH2 1 
ATOM   4718 N  N   . GLU   B 1 347 ? -8.81200  21.19329  -62.28887 1.000 26.41405 ? 347 GLU   B N   1 
ATOM   4719 C  CA  . GLU   B 1 347 ? -7.60586  20.73012  -61.61151 1.000 31.23990 ? 347 GLU   B CA  1 
ATOM   4720 C  C   . GLU   B 1 347 ? -6.40977  21.62630  -61.90637 1.000 41.46239 ? 347 GLU   B C   1 
ATOM   4721 O  O   . GLU   B 1 347 ? -5.56371  21.83550  -61.02986 1.000 41.83410 ? 347 GLU   B O   1 
ATOM   4722 C  CB  . GLU   B 1 347 ? -7.29862  19.28924  -62.01700 1.000 32.87741 ? 347 GLU   B CB  1 
ATOM   4723 C  CG  . GLU   B 1 347 ? -8.28857  18.27137  -61.47981 1.000 32.45779 ? 347 GLU   B CG  1 
ATOM   4724 C  CD  . GLU   B 1 347 ? -8.12199  16.90631  -62.11501 1.000 30.86924 ? 347 GLU   B CD  1 
ATOM   4725 O  OE1 . GLU   B 1 347 ? -7.67458  16.84018  -63.27922 1.000 34.02032 ? 347 GLU   B OE1 1 
ATOM   4726 O  OE2 . GLU   B 1 347 ? -8.43724  15.89859  -61.44932 1.000 27.15214 ? 347 GLU   B OE2 1 
ATOM   4727 N  N   . ARG   B 1 348 ? -6.31864  22.16153  -63.12444 1.000 37.39911 ? 348 ARG   B N   1 
ATOM   4728 C  CA  . ARG   B 1 348 ? -5.18745  23.01361  -63.47311 1.000 44.89366 ? 348 ARG   B CA  1 
ATOM   4729 C  C   . ARG   B 1 348 ? -5.32468  24.40209  -62.85853 1.000 43.03066 ? 348 ARG   B C   1 
ATOM   4730 O  O   . ARG   B 1 348 ? -4.33546  24.96751  -62.37834 1.000 44.16885 ? 348 ARG   B O   1 
ATOM   4731 C  CB  . ARG   B 1 348 ? -5.05391  23.10428  -64.99333 1.000 40.67403 ? 348 ARG   B CB  1 
ATOM   4732 C  CG  . ARG   B 1 348 ? -3.64945  23.40368  -65.49133 1.000 42.36028 ? 348 ARG   B CG  1 
ATOM   4733 C  CD  . ARG   B 1 348 ? -3.56146  23.21291  -66.99908 1.000 42.64721 ? 348 ARG   B CD  1 
ATOM   4734 N  NE  . ARG   B 1 348 ? -4.86920  23.34579  -67.63723 1.000 49.05059 ? 348 ARG   B NE  1 
ATOM   4735 C  CZ  . ARG   B 1 348 ? -5.45642  22.39171  -68.35380 1.000 38.52414 ? 348 ARG   B CZ  1 
ATOM   4736 N  NH1 . ARG   B 1 348 ? -4.84803  21.23008  -68.54497 1.000 38.42220 ? 348 ARG   B NH1 1 
ATOM   4737 N  NH2 . ARG   B 1 348 ? -6.64952  22.60390  -68.89129 1.000 31.49086 ? 348 ARG   B NH2 1 
ATOM   4738 N  N   . GLU   B 1 349 ? -6.53946  24.96449  -62.87333 1.000 39.98178 ? 349 GLU   B N   1 
ATOM   4739 C  CA  . GLU   B 1 349 ? -6.79309  26.23098  -62.19005 1.000 43.27726 ? 349 GLU   B CA  1 
ATOM   4740 C  C   . GLU   B 1 349 ? -6.34018  26.17675  -60.73878 1.000 45.99556 ? 349 GLU   B C   1 
ATOM   4741 O  O   . GLU   B 1 349 ? -5.70449  27.11245  -60.23964 1.000 42.19564 ? 349 GLU   B O   1 
ATOM   4742 C  CB  . GLU   B 1 349 ? -8.28135  26.57856  -62.24722 1.000 42.60174 ? 349 GLU   B CB  1 
ATOM   4743 C  CG  . GLU   B 1 349 ? -8.81116  26.97864  -63.60493 1.000 51.19948 ? 349 GLU   B CG  1 
ATOM   4744 C  CD  . GLU   B 1 349 ? -10.14868 27.68702  -63.49880 1.000 60.72324 ? 349 GLU   B CD  1 
ATOM   4745 O  OE1 . GLU   B 1 349 ? -11.14093 27.03410  -63.11436 1.000 56.07929 ? 349 GLU   B OE1 1 
ATOM   4746 O  OE2 . GLU   B 1 349 ? -10.20742 28.90019  -63.78452 1.000 68.05693 ? 349 GLU   B OE2 1 
ATOM   4747 N  N   . ARG   B 1 350 ? -6.66907  25.08898  -60.04491 1.000 40.91807 ? 350 ARG   B N   1 
ATOM   4748 C  CA  . ARG   B 1 350 ? -6.29100  24.89179  -58.65282 1.000 41.51083 ? 350 ARG   B CA  1 
ATOM   4749 C  C   . ARG   B 1 350 ? -4.86160  24.40292  -58.49405 1.000 38.94984 ? 350 ARG   B C   1 
ATOM   4750 O  O   . ARG   B 1 350 ? -4.41794  24.19109  -57.36020 1.000 45.83621 ? 350 ARG   B O   1 
ATOM   4751 C  CB  . ARG   B 1 350 ? -7.23222  23.88542  -57.99253 1.000 37.49831 ? 350 ARG   B CB  1 
ATOM   4752 C  CG  . ARG   B 1 350 ? -8.69661  24.25696  -58.02982 1.000 40.71579 ? 350 ARG   B CG  1 
ATOM   4753 C  CD  . ARG   B 1 350 ? -9.53602  23.01176  -57.82059 1.000 47.31864 ? 350 ARG   B CD  1 
ATOM   4754 N  NE  . ARG   B 1 350 ? -10.71046 23.26605  -56.99776 1.000 44.57023 ? 350 ARG   B NE  1 
ATOM   4755 C  CZ  . ARG   B 1 350 ? -10.76269 23.02794  -55.69232 1.000 41.96214 ? 350 ARG   B CZ  1 
ATOM   4756 N  NH1 . ARG   B 1 350 ? -9.70183  22.53880  -55.06297 1.000 39.29369 ? 350 ARG   B NH1 1 
ATOM   4757 N  NH2 . ARG   B 1 350 ? -11.87210 23.28461  -55.01473 1.000 46.30861 ? 350 ARG   B NH2 1 
ATOM   4758 N  N   . GLY   B 1 351 ? -4.14077  24.20275  -59.59158 1.000 37.43525 ? 351 GLY   B N   1 
ATOM   4759 C  CA  . GLY   B 1 351 ? -2.80018  23.66605  -59.49217 1.000 37.69346 ? 351 GLY   B CA  1 
ATOM   4760 C  C   . GLY   B 1 351 ? -2.75049  22.23857  -59.00561 1.000 37.03641 ? 351 GLY   B C   1 
ATOM   4761 O  O   . GLY   B 1 351 ? -1.73357  21.80913  -58.44973 1.000 37.96176 ? 351 GLY   B O   1 
ATOM   4762 N  N   . MET   B 1 352 ? -3.83208  21.49257  -59.18829 1.000 40.35274 ? 352 MET   B N   1 
ATOM   4763 C  CA  . MET   B 1 352 ? -3.84701  20.08982  -58.82457 1.000 41.20532 ? 352 MET   B CA  1 
ATOM   4764 C  C   . MET   B 1 352 ? -3.21232  19.25703  -59.92973 1.000 40.28860 ? 352 MET   B C   1 
ATOM   4765 O  O   . MET   B 1 352 ? -3.08401  19.69170  -61.07816 1.000 39.28993 ? 352 MET   B O   1 
ATOM   4766 C  CB  . MET   B 1 352 ? -5.27712  19.61083  -58.57872 1.000 42.47175 ? 352 MET   B CB  1 
ATOM   4767 C  CG  . MET   B 1 352 ? -6.05474  20.42571  -57.56223 1.000 44.23690 ? 352 MET   B CG  1 
ATOM   4768 S  SD  . MET   B 1 352 ? -7.76629  19.87176  -57.44559 1.000 37.82474 ? 352 MET   B SD  1 
ATOM   4769 C  CE  . MET   B 1 352 ? -7.53326  18.17328  -56.93099 1.000 30.49451 ? 352 MET   B CE  1 
ATOM   4770 N  N   . GLU   B 1 353 ? -2.80579  18.04506  -59.56644 1.000 39.11485 ? 353 GLU   B N   1 
ATOM   4771 C  CA  . GLU   B 1 353 ? -2.41349  17.07557  -60.57546 1.000 40.82333 ? 353 GLU   B CA  1 
ATOM   4772 C  C   . GLU   B 1 353 ? -3.60155  16.77587  -61.47617 1.000 41.99172 ? 353 GLU   B C   1 
ATOM   4773 O  O   . GLU   B 1 353 ? -4.70911  16.50984  -60.99893 1.000 34.16088 ? 353 GLU   B O   1 
ATOM   4774 C  CB  . GLU   B 1 353 ? -1.90583  15.79110  -59.92318 1.000 36.57974 ? 353 GLU   B CB  1 
ATOM   4775 C  CG  . GLU   B 1 353 ? -2.14794  14.55230  -60.77350 1.000 45.67758 ? 353 GLU   B CG  1 
ATOM   4776 C  CD  . GLU   B 1 353 ? -1.15326  13.44209  -60.50811 1.000 46.71733 ? 353 GLU   B CD  1 
ATOM   4777 O  OE1 . GLU   B 1 353 ? -0.34729  13.57264  -59.56412 1.000 51.96585 ? 353 GLU   B OE1 1 
ATOM   4778 O  OE2 . GLU   B 1 353 ? -1.17792  12.43589  -61.24813 1.000 56.25365 ? 353 GLU   B OE2 1 
ATOM   4779 N  N   . ILE   B 1 354 ? -3.37417  16.83800  -62.78018 1.000 40.47476 ? 354 ILE   B N   1 
ATOM   4780 C  CA  . ILE   B 1 354 ? -4.43425  16.57398  -63.74193 1.000 37.50699 ? 354 ILE   B CA  1 
ATOM   4781 C  C   . ILE   B 1 354 ? -4.67417  15.07355  -63.80727 1.000 37.47715 ? 354 ILE   B C   1 
ATOM   4782 O  O   . ILE   B 1 354 ? -3.74130  14.29022  -64.02372 1.000 39.83227 ? 354 ILE   B O   1 
ATOM   4783 C  CB  . ILE   B 1 354 ? -4.07447  17.14837  -65.11844 1.000 39.12941 ? 354 ILE   B CB  1 
ATOM   4784 C  CG1 . ILE   B 1 354 ? -3.74955  18.63593  -64.98592 1.000 39.42929 ? 354 ILE   B CG1 1 
ATOM   4785 C  CG2 . ILE   B 1 354 ? -5.22286  16.93866  -66.08892 1.000 34.02747 ? 354 ILE   B CG2 1 
ATOM   4786 C  CD1 . ILE   B 1 354 ? -3.55227  19.33179  -66.29977 1.000 33.31472 ? 354 ILE   B CD1 1 
ATOM   4787 N  N   . SER   B 1 355 ? -5.92590  14.67217  -63.60336 1.000 29.91384 ? 355 SER   B N   1 
ATOM   4788 C  CA  . SER   B 1 355 ? -6.28878  13.26763  -63.60594 1.000 33.51377 ? 355 SER   B CA  1 
ATOM   4789 C  C   . SER   B 1 355 ? -6.04295  12.65183  -64.98233 1.000 30.14921 ? 355 SER   B C   1 
ATOM   4790 O  O   . SER   B 1 355 ? -5.96678  13.36509  -65.98620 1.000 30.61192 ? 355 SER   B O   1 
ATOM   4791 C  CB  . SER   B 1 355 ? -7.75315  13.10863  -63.20386 1.000 29.94247 ? 355 SER   B CB  1 
ATOM   4792 O  OG  . SER   B 1 355 ? -7.98544  13.66994  -61.92401 1.000 30.85420 ? 355 SER   B OG  1 
ATOM   4793 N  N   . PRO   B 1 356 ? -5.89438  11.32587  -65.04935 1.000 28.58021 ? 356 PRO   B N   1 
ATOM   4794 C  CA  . PRO   B 1 356 ? -5.68995  10.67566  -66.34878 1.000 30.24595 ? 356 PRO   B CA  1 
ATOM   4795 C  C   . PRO   B 1 356 ? -6.81346  11.00747  -67.31666 1.000 32.92351 ? 356 PRO   B C   1 
ATOM   4796 O  O   . PRO   B 1 356 ? -7.98081  11.10879  -66.93249 1.000 30.01594 ? 356 PRO   B O   1 
ATOM   4797 C  CB  . PRO   B 1 356 ? -5.67382  9.18303   -66.00133 1.000 28.44670 ? 356 PRO   B CB  1 
ATOM   4798 C  CG  . PRO   B 1 356 ? -5.23992  9.13348   -64.58973 1.000 31.82398 ? 356 PRO   B CG  1 
ATOM   4799 C  CD  . PRO   B 1 356 ? -5.81211  10.36136  -63.93726 1.000 31.50872 ? 356 PRO   B CD  1 
ATOM   4800 N  N   . MET   B 1 357 ? -6.43900  11.19795  -68.58163 1.000 31.54571 ? 357 MET   B N   1 
ATOM   4801 C  CA  . MET   B 1 357 ? -7.32763  11.48170  -69.70423 1.000 28.86290 ? 357 MET   B CA  1 
ATOM   4802 C  C   . MET   B 1 357 ? -8.02164  12.83450  -69.59274 1.000 27.36352 ? 357 MET   B C   1 
ATOM   4803 O  O   . MET   B 1 357 ? -8.85191  13.15478  -70.45066 1.000 29.87370 ? 357 MET   B O   1 
ATOM   4804 C  CB  . MET   B 1 357 ? -8.39690  10.39348  -69.87763 1.000 26.20809 ? 357 MET   B CB  1 
ATOM   4805 C  CG  . MET   B 1 357 ? -7.81645  8.99406   -69.98850 1.000 25.09883 ? 357 MET   B CG  1 
ATOM   4806 S  SD  . MET   B 1 357 ? -9.05657  7.69107   -70.07905 1.000 31.79529 ? 357 MET   B SD  1 
ATOM   4807 C  CE  . MET   B 1 357 ? -9.60339  7.61155   -68.37421 1.000 26.88155 ? 357 MET   B CE  1 
ATOM   4808 N  N   . CYS   B 1 358 ? -7.71340  13.64112  -68.57762 1.000 28.56217 ? 358 CYS   B N   1 
ATOM   4809 C  CA  . CYS   B 1 358 ? -8.42462  14.88860  -68.32639 1.000 26.59523 ? 358 CYS   B CA  1 
ATOM   4810 C  C   . CYS   B 1 358 ? -7.66313  16.12463  -68.78774 1.000 23.88845 ? 358 CYS   B C   1 
ATOM   4811 O  O   . CYS   B 1 358 ? -8.13535  17.24303  -68.56100 1.000 24.25966 ? 358 CYS   B O   1 
ATOM   4812 C  CB  . CYS   B 1 358 ? -8.74815  15.01938  -66.83361 1.000 28.39256 ? 358 CYS   B CB  1 
ATOM   4813 S  SG  . CYS   B 1 358 ? -9.94602  13.81372  -66.21435 1.000 25.96772 ? 358 CYS   B SG  1 
ATOM   4814 N  N   . ASP   B 1 359 ? -6.50473  15.95796  -69.42168 1.000 26.31480 ? 359 ASP   B N   1 
ATOM   4815 C  CA  . ASP   B 1 359 ? -5.69140  17.07778  -69.88479 1.000 29.15415 ? 359 ASP   B CA  1 
ATOM   4816 C  C   . ASP   B 1 359 ? -5.93936  17.27273  -71.37652 1.000 27.83594 ? 359 ASP   B C   1 
ATOM   4817 O  O   . ASP   B 1 359 ? -5.47793  16.47472  -72.19880 1.000 27.67832 ? 359 ASP   B O   1 
ATOM   4818 C  CB  . ASP   B 1 359 ? -4.21173  16.83036  -69.59760 1.000 33.16439 ? 359 ASP   B CB  1 
ATOM   4819 C  CG  . ASP   B 1 359 ? -3.34312  18.02760  -69.93365 1.000 36.29049 ? 359 ASP   B CG  1 
ATOM   4820 O  OD1 . ASP   B 1 359 ? -3.89915  19.09517  -70.26666 1.000 30.06844 ? 359 ASP   B OD1 1 
ATOM   4821 O  OD2 . ASP   B 1 359 ? -2.10290  17.90343  -69.85754 1.000 35.33442 ? 359 ASP   B OD2 1 
ATOM   4822 N  N   . LYS   B 1 360 ? -6.66092  18.34223  -71.72179 1.000 27.13263 ? 360 LYS   B N   1 
ATOM   4823 C  CA  . LYS   B 1 360 ? -6.99633  18.62706  -73.11183 1.000 28.77995 ? 360 LYS   B CA  1 
ATOM   4824 C  C   . LYS   B 1 360 ? -5.79533  19.07248  -73.93491 1.000 40.92020 ? 360 LYS   B C   1 
ATOM   4825 O  O   . LYS   B 1 360 ? -5.90885  19.16161  -75.16216 1.000 44.82217 ? 360 LYS   B O   1 
ATOM   4826 C  CB  . LYS   B 1 360 ? -8.08941  19.69485  -73.17719 1.000 33.94865 ? 360 LYS   B CB  1 
ATOM   4827 C  CG  . LYS   B 1 360 ? -7.62506  21.08164  -72.76926 1.000 36.45354 ? 360 LYS   B CG  1 
ATOM   4828 C  CD  . LYS   B 1 360 ? -8.78677  22.05819  -72.71648 1.000 37.51093 ? 360 LYS   B CD  1 
ATOM   4829 C  CE  . LYS   B 1 360 ? -8.36988  23.36907  -72.07151 1.000 35.10142 ? 360 LYS   B CE  1 
ATOM   4830 N  NZ  . LYS   B 1 360 ? -9.53106  24.27048  -71.83400 1.000 33.95632 ? 360 LYS   B NZ  1 
ATOM   4831 N  N   . HIS   B 1 361 ? -4.66167  19.36270  -73.30047 1.000 39.64784 ? 361 HIS   B N   1 
ATOM   4832 C  CA  . HIS   B 1 361 ? -3.43218  19.68430  -74.00969 1.000 42.42071 ? 361 HIS   B CA  1 
ATOM   4833 C  C   . HIS   B 1 361 ? -2.50166  18.48608  -74.12838 1.000 39.75809 ? 361 HIS   B C   1 
ATOM   4834 O  O   . HIS   B 1 361 ? -1.37281  18.63551  -74.60538 1.000 49.82643 ? 361 HIS   B O   1 
ATOM   4835 C  CB  . HIS   B 1 361 ? -2.70123  20.83558  -73.31632 1.000 33.86405 ? 361 HIS   B CB  1 
ATOM   4836 C  CG  . HIS   B 1 361 ? -3.55041  22.04718  -73.09274 1.000 33.71582 ? 361 HIS   B CG  1 
ATOM   4837 N  ND1 . HIS   B 1 361 ? -4.16770  22.72518  -74.12177 1.000 36.51888 ? 361 HIS   B ND1 1 
ATOM   4838 C  CD2 . HIS   B 1 361 ? -3.87496  22.70972  -71.95756 1.000 30.79493 ? 361 HIS   B CD2 1 
ATOM   4839 C  CE1 . HIS   B 1 361 ? -4.84097  23.74969  -73.62945 1.000 38.33687 ? 361 HIS   B CE1 1 
ATOM   4840 N  NE2 . HIS   B 1 361 ? -4.67935  23.76303  -72.31858 1.000 41.29287 ? 361 HIS   B NE2 1 
ATOM   4841 N  N   . ASN   B 1 362 ? -2.94574  17.30526  -73.70183 1.000 37.50520 ? 362 ASN   B N   1 
ATOM   4842 C  CA  . ASN   B 1 362 ? -2.09587  16.12199  -73.70262 1.000 37.54872 ? 362 ASN   B CA  1 
ATOM   4843 C  C   . ASN   B 1 362 ? -2.95409  14.86420  -73.68001 1.000 42.30506 ? 362 ASN   B C   1 
ATOM   4844 O  O   . ASN   B 1 362 ? -2.74558  13.97042  -72.85300 1.000 47.48345 ? 362 ASN   B O   1 
ATOM   4845 C  CB  . ASN   B 1 362 ? -1.14151  16.15197  -72.50585 1.000 40.82815 ? 362 ASN   B CB  1 
ATOM   4846 C  CG  . ASN   B 1 362 ? -0.04192  15.11177  -72.60655 1.000 47.92746 ? 362 ASN   B CG  1 
ATOM   4847 O  OD1 . ASN   B 1 362 ? 0.12067   14.46057  -73.63836 1.000 58.65341 ? 362 ASN   B OD1 1 
ATOM   4848 N  ND2 . ASN   B 1 362 ? 0.72247   14.95367  -71.53200 1.000 50.76450 ? 362 ASN   B ND2 1 
ATOM   4849 N  N   . ALA   B 1 363 ? -3.92416  14.78938  -74.58293 1.000 36.36030 ? 363 ALA   B N   1 
ATOM   4850 C  CA  . ALA   B 1 363 ? -4.84885  13.67158  -74.64515 1.000 36.49853 ? 363 ALA   B CA  1 
ATOM   4851 C  C   . ALA   B 1 363 ? -4.65256  12.88739  -75.93426 1.000 30.61187 ? 363 ALA   B C   1 
ATOM   4852 O  O   . ALA   B 1 363 ? -4.19947  13.42404  -76.94936 1.000 31.76534 ? 363 ALA   B O   1 
ATOM   4853 C  CB  . ALA   B 1 363 ? -6.30019  14.15192  -74.55355 1.000 29.16074 ? 363 ALA   B CB  1 
ATOM   4854 N  N   . SER   B 1 364 ? -4.98716  11.60024  -75.87369 1.000 31.41494 ? 364 SER   B N   1 
ATOM   4855 C  CA  . SER   B 1 364 ? -5.14759  10.75809  -77.05679 1.000 23.30415 ? 364 SER   B CA  1 
ATOM   4856 C  C   . SER   B 1 364 ? -6.50687  10.08918  -76.89294 1.000 19.82826 ? 364 SER   B C   1 
ATOM   4857 O  O   . SER   B 1 364 ? -6.61038  9.00700   -76.30813 1.000 16.82435 ? 364 SER   B O   1 
ATOM   4858 C  CB  . SER   B 1 364 ? -4.02649  9.74552   -77.20509 1.000 29.39207 ? 364 SER   B CB  1 
ATOM   4859 O  OG  . SER   B 1 364 ? -4.21070  8.99844   -78.39413 1.000 38.41583 ? 364 SER   B OG  1 
ATOM   4860 N  N   . VAL   B 1 365 ? -7.54398  10.75925  -77.39900 1.000 19.58647 ? 365 VAL   B N   1 
ATOM   4861 C  CA  . VAL   B 1 365 ? -8.91208  10.27209  -77.25224 1.000 21.08938 ? 365 VAL   B CA  1 
ATOM   4862 C  C   . VAL   B 1 365 ? -9.04251  8.85769   -77.80203 1.000 19.65019 ? 365 VAL   B C   1 
ATOM   4863 O  O   . VAL   B 1 365 ? -9.67349  7.99030   -77.18505 1.000 18.06411 ? 365 VAL   B O   1 
ATOM   4864 C  CB  . VAL   B 1 365 ? -9.88866  11.24164  -77.94407 1.000 20.80648 ? 365 VAL   B CB  1 
ATOM   4865 C  CG1 . VAL   B 1 365 ? -11.29139 10.66725  -77.96210 1.000 18.12579 ? 365 VAL   B CG1 1 
ATOM   4866 C  CG2 . VAL   B 1 365 ? -9.86716  12.59958  -77.25691 1.000 19.48302 ? 365 VAL   B CG2 1 
ATOM   4867 N  N   . GLU   B 1 366 ? -8.43089  8.59647   -78.95798 1.000 16.22732 ? 366 GLU   B N   1 
ATOM   4868 C  CA  . GLU   B 1 366 ? -8.61431  7.30984   -79.62134 1.000 18.60744 ? 366 GLU   B CA  1 
ATOM   4869 C  C   . GLU   B 1 366 ? -7.85778  6.20159   -78.89877 1.000 19.82112 ? 366 GLU   B C   1 
ATOM   4870 O  O   . GLU   B 1 366 ? -8.39990  5.11194   -78.67718 1.000 17.45051 ? 366 GLU   B O   1 
ATOM   4871 C  CB  . GLU   B 1 366 ? -8.17743  7.40904   -81.08350 1.000 18.51182 ? 366 GLU   B CB  1 
ATOM   4872 C  CG  . GLU   B 1 366 ? -9.00384  8.38620   -81.91610 1.000 17.54620 ? 366 GLU   B CG  1 
ATOM   4873 C  CD  . GLU   B 1 366 ? -8.66095  9.84103   -81.64738 1.000 20.58425 ? 366 GLU   B CD  1 
ATOM   4874 O  OE1 . GLU   B 1 366 ? -9.48529  10.71779  -81.98002 1.000 20.37673 ? 366 GLU   B OE1 1 
ATOM   4875 O  OE2 . GLU   B 1 366 ? -7.57068  10.10651  -81.09907 1.000 20.06869 ? 366 GLU   B OE2 1 
ATOM   4876 N  N   . LYS   B 1 367 ? -6.60113  6.46132   -78.52221 1.000 14.85339 ? 367 LYS   B N   1 
ATOM   4877 C  CA  . LYS   B 1 367 ? -5.83813  5.47065   -77.76782 1.000 21.14656 ? 367 LYS   B CA  1 
ATOM   4878 C  C   . LYS   B 1 367 ? -6.51157  5.15608   -76.43901 1.000 18.67665 ? 367 LYS   B C   1 
ATOM   4879 O  O   . LYS   B 1 367 ? -6.49854  4.00572   -75.98566 1.000 19.78291 ? 367 LYS   B O   1 
ATOM   4880 C  CB  . LYS   B 1 367 ? -4.40664  5.95920   -77.53546 1.000 22.65164 ? 367 LYS   B CB  1 
ATOM   4881 C  CG  . LYS   B 1 367 ? -3.51243  5.90494   -78.76575 1.000 26.49968 ? 367 LYS   B CG  1 
ATOM   4882 C  CD  . LYS   B 1 367 ? -2.20652  6.65658   -78.53930 1.000 32.94707 ? 367 LYS   B CD  1 
ATOM   4883 C  CE  . LYS   B 1 367 ? -1.52430  6.99130   -79.85650 1.000 37.65764 ? 367 LYS   B CE  1 
ATOM   4884 N  NZ  . LYS   B 1 367 ? -0.21887  7.67683   -79.64770 1.000 41.19049 ? 367 LYS   B NZ  1 
ATOM   4885 N  N   . SER   B 1 368 ? -7.11029  6.16692   -75.80246 1.000 17.57358 ? 368 SER   B N   1 
ATOM   4886 C  CA  . SER   B 1 368 ? -7.81321  5.93632   -74.54461 1.000 17.90946 ? 368 SER   B CA  1 
ATOM   4887 C  C   . SER   B 1 368 ? -8.99807  4.99848   -74.73820 1.000 19.90167 ? 368 SER   B C   1 
ATOM   4888 O  O   . SER   B 1 368 ? -9.22325  4.09820   -73.92155 1.000 19.91368 ? 368 SER   B O   1 
ATOM   4889 C  CB  . SER   B 1 368 ? -8.27289  7.26576   -73.94471 1.000 17.03374 ? 368 SER   B CB  1 
ATOM   4890 O  OG  . SER   B 1 368 ? -7.16959  8.03358   -73.49566 1.000 22.03287 ? 368 SER   B OG  1 
ATOM   4891 N  N   . GLN   B 1 369 ? -9.76464  5.18936   -75.81622 1.000 15.36400 ? 369 GLN   B N   1 
ATOM   4892 C  CA  . GLN   B 1 369 ? -10.90684 4.31628   -76.07219 1.000 18.39960 ? 369 GLN   B CA  1 
ATOM   4893 C  C   . GLN   B 1 369 ? -10.46341 2.87812   -76.30197 1.000 16.19968 ? 369 GLN   B C   1 
ATOM   4894 O  O   . GLN   B 1 369 ? -11.08702 1.93960   -75.79213 1.000 14.64422 ? 369 GLN   B O   1 
ATOM   4895 C  CB  . GLN   B 1 369 ? -11.70666 4.82766   -77.27021 1.000 17.12195 ? 369 GLN   B CB  1 
ATOM   4896 C  CG  . GLN   B 1 369 ? -12.59556 6.01499   -76.95266 1.000 16.69735 ? 369 GLN   B CG  1 
ATOM   4897 C  CD  . GLN   B 1 369 ? -13.45344 5.78168   -75.72349 1.000 18.08770 ? 369 GLN   B CD  1 
ATOM   4898 O  OE1 . GLN   B 1 369 ? -14.15819 4.77652   -75.62375 1.000 18.69314 ? 369 GLN   B OE1 1 
ATOM   4899 N  NE2 . GLN   B 1 369 ? -13.39574 6.71116   -74.77847 1.000 17.46877 ? 369 GLN   B NE2 1 
ATOM   4900 N  N   . VAL   B 1 370 ? -9.38625  2.68497   -77.06496 1.000 18.04833 ? 370 VAL   B N   1 
ATOM   4901 C  CA  . VAL   B 1 370 ? -8.87528  1.33700   -77.29933 1.000 18.18916 ? 370 VAL   B CA  1 
ATOM   4902 C  C   . VAL   B 1 370 ? -8.42002  0.70876   -75.98858 1.000 20.03503 ? 370 VAL   B C   1 
ATOM   4903 O  O   . VAL   B 1 370 ? -8.74367  -0.44647  -75.68774 1.000 21.02696 ? 370 VAL   B O   1 
ATOM   4904 C  CB  . VAL   B 1 370 ? -7.74011  1.36392   -78.33725 1.000 17.60668 ? 370 VAL   B CB  1 
ATOM   4905 C  CG1 . VAL   B 1 370 ? -7.12828  -0.01987  -78.48272 1.000 16.80233 ? 370 VAL   B CG1 1 
ATOM   4906 C  CG2 . VAL   B 1 370 ? -8.26430  1.85952   -79.67325 1.000 19.75169 ? 370 VAL   B CG2 1 
ATOM   4907 N  N   . GLY   B 1 371 ? -7.66061  1.46099   -75.18909 1.000 19.67826 ? 371 GLY   B N   1 
ATOM   4908 C  CA  . GLY   B 1 371 ? -7.25197  0.95396   -73.88821 1.000 20.45298 ? 371 GLY   B CA  1 
ATOM   4909 C  C   . GLY   B 1 371 ? -8.43653  0.67779   -72.98330 1.000 21.24838 ? 371 GLY   B C   1 
ATOM   4910 O  O   . GLY   B 1 371 ? -8.49189  -0.35181  -72.30602 1.000 25.33216 ? 371 GLY   B O   1 
ATOM   4911 N  N   . PHE   B 1 372 ? -9.40316  1.59963   -72.96675 1.000 19.26242 ? 372 PHE   B N   1 
ATOM   4912 C  CA  . PHE   B 1 372 ? -10.64306 1.40126   -72.22075 1.000 17.97001 ? 372 PHE   B CA  1 
ATOM   4913 C  C   . PHE   B 1 372 ? -11.31583 0.08974   -72.61306 1.000 20.03036 ? 372 PHE   B C   1 
ATOM   4914 O  O   . PHE   B 1 372 ? -11.70333 -0.70779  -71.75134 1.000 20.30632 ? 372 PHE   B O   1 
ATOM   4915 C  CB  . PHE   B 1 372 ? -11.56817 2.59815   -72.46687 1.000 21.71147 ? 372 PHE   B CB  1 
ATOM   4916 C  CG  . PHE   B 1 372 ? -12.85382 2.56946   -71.68562 1.000 20.65899 ? 372 PHE   B CG  1 
ATOM   4917 C  CD1 . PHE   B 1 372 ? -12.86698 2.24970   -70.33818 1.000 19.03541 ? 372 PHE   B CD1 1 
ATOM   4918 C  CD2 . PHE   B 1 372 ? -14.04969 2.91039   -72.30035 1.000 19.24234 ? 372 PHE   B CD2 1 
ATOM   4919 C  CE1 . PHE   B 1 372 ? -14.05579 2.24093   -69.62648 1.000 20.47518 ? 372 PHE   B CE1 1 
ATOM   4920 C  CE2 . PHE   B 1 372 ? -15.23855 2.90842   -71.59520 1.000 19.80978 ? 372 PHE   B CE2 1 
ATOM   4921 C  CZ  . PHE   B 1 372 ? -15.24199 2.57442   -70.25554 1.000 16.38443 ? 372 PHE   B CZ  1 
ATOM   4922 N  N   . ILE   B 1 373 ? -11.43639 -0.16012  -73.91928 1.000 18.21876 ? 373 ILE   B N   1 
ATOM   4923 C  CA  . ILE   B 1 373 ? -12.05313 -1.39695  -74.39592 1.000 23.05547 ? 373 ILE   B CA  1 
ATOM   4924 C  C   . ILE   B 1 373 ? -11.19996 -2.60197  -74.01530 1.000 21.55493 ? 373 ILE   B C   1 
ATOM   4925 O  O   . ILE   B 1 373 ? -11.70257 -3.59572  -73.47730 1.000 24.10917 ? 373 ILE   B O   1 
ATOM   4926 C  CB  . ILE   B 1 373 ? -12.28097 -1.33067  -75.91746 1.000 20.04392 ? 373 ILE   B CB  1 
ATOM   4927 C  CG1 . ILE   B 1 373 ? -13.38245 -0.32465  -76.25522 1.000 17.91496 ? 373 ILE   B CG1 1 
ATOM   4928 C  CG2 . ILE   B 1 373 ? -12.62576 -2.70708  -76.47033 1.000 20.67183 ? 373 ILE   B CG2 1 
ATOM   4929 C  CD1 . ILE   B 1 373 ? -13.50392 -0.03309  -77.73637 1.000 12.34438 ? 373 ILE   B CD1 1 
ATOM   4930 N  N   . ASP   B 1 374 ? -9.89313  -2.52818  -74.28527 1.000 20.39188 ? 374 ASP   B N   1 
ATOM   4931 C  CA  . ASP   B 1 374 ? -9.02624  -3.68908  -74.09786 1.000 24.04300 ? 374 ASP   B CA  1 
ATOM   4932 C  C   . ASP   B 1 374 ? -8.98761  -4.14174  -72.64300 1.000 26.64812 ? 374 ASP   B C   1 
ATOM   4933 O  O   . ASP   B 1 374 ? -8.98795  -5.34600  -72.36189 1.000 27.15308 ? 374 ASP   B O   1 
ATOM   4934 C  CB  . ASP   B 1 374 ? -7.61191  -3.37720  -74.59014 1.000 22.92779 ? 374 ASP   B CB  1 
ATOM   4935 C  CG  . ASP   B 1 374 ? -7.51790  -3.32614  -76.10085 1.000 23.01803 ? 374 ASP   B CG  1 
ATOM   4936 O  OD1 . ASP   B 1 374 ? -8.51079  -3.68187  -76.76918 1.000 23.91774 ? 374 ASP   B OD1 1 
ATOM   4937 O  OD2 . ASP   B 1 374 ? -6.44833  -2.94340  -76.62043 1.000 17.68190 ? 374 ASP   B OD2 1 
ATOM   4938 N  N   . TYR   B 1 375 ? -8.95868  -3.19783  -71.70272 1.000 22.90856 ? 375 TYR   B N   1 
ATOM   4939 C  CA  . TYR   B 1 375 ? -8.69378  -3.54069  -70.31211 1.000 25.67995 ? 375 TYR   B CA  1 
ATOM   4940 C  C   . TYR   B 1 375 ? -9.92455  -3.51779  -69.41660 1.000 24.42615 ? 375 TYR   B C   1 
ATOM   4941 O  O   . TYR   B 1 375 ? -9.90944  -4.16627  -68.36480 1.000 24.52470 ? 375 TYR   B O   1 
ATOM   4942 C  CB  . TYR   B 1 375 ? -7.62588  -2.60367  -69.73518 1.000 25.30900 ? 375 TYR   B CB  1 
ATOM   4943 C  CG  . TYR   B 1 375 ? -6.26225  -2.84493  -70.33614 1.000 34.00622 ? 375 TYR   B CG  1 
ATOM   4944 C  CD1 . TYR   B 1 375 ? -5.51868  -3.96306  -69.98177 1.000 39.13864 ? 375 TYR   B CD1 1 
ATOM   4945 C  CD2 . TYR   B 1 375 ? -5.72523  -1.96833  -71.27000 1.000 34.72314 ? 375 TYR   B CD2 1 
ATOM   4946 C  CE1 . TYR   B 1 375 ? -4.27545  -4.19815  -70.53226 1.000 39.75829 ? 375 TYR   B CE1 1 
ATOM   4947 C  CE2 . TYR   B 1 375 ? -4.48080  -2.19464  -71.82644 1.000 41.87748 ? 375 TYR   B CE2 1 
ATOM   4948 C  CZ  . TYR   B 1 375 ? -3.76085  -3.31104  -71.45348 1.000 44.16971 ? 375 TYR   B CZ  1 
ATOM   4949 O  OH  . TYR   B 1 375 ? -2.52161  -3.54063  -72.00457 1.000 50.95510 ? 375 TYR   B OH  1 
ATOM   4950 N  N   . ILE   B 1 376 ? -10.98561 -2.80931  -69.79720 1.000 22.53355 ? 376 ILE   B N   1 
ATOM   4951 C  CA  . ILE   B 1 376 ? -12.17665 -2.74243  -68.95702 1.000 17.77754 ? 376 ILE   B CA  1 
ATOM   4952 C  C   . ILE   B 1 376 ? -13.37873 -3.33694  -69.67919 1.000 21.82692 ? 376 ILE   B C   1 
ATOM   4953 O  O   . ILE   B 1 376 ? -13.98119 -4.30901  -69.20941 1.000 16.51573 ? 376 ILE   B O   1 
ATOM   4954 C  CB  . ILE   B 1 376 ? -12.47497 -1.29548  -68.52193 1.000 22.68560 ? 376 ILE   B CB  1 
ATOM   4955 C  CG1 . ILE   B 1 376 ? -11.28293 -0.69635  -67.77130 1.000 23.63071 ? 376 ILE   B CG1 1 
ATOM   4956 C  CG2 . ILE   B 1 376 ? -13.72752 -1.25179  -67.65864 1.000 20.04761 ? 376 ILE   B CG2 1 
ATOM   4957 C  CD1 . ILE   B 1 376 ? -10.83462 -1.51290  -66.57876 1.000 29.47108 ? 376 ILE   B CD1 1 
ATOM   4958 N  N   . VAL   B 1 377 ? -13.72807 -2.76208  -70.83165 1.000 20.50622 ? 377 VAL   B N   1 
ATOM   4959 C  CA  . VAL   B 1 377 ? -15.04216 -3.01066  -71.41797 1.000 16.59235 ? 377 VAL   B CA  1 
ATOM   4960 C  C   . VAL   B 1 377 ? -15.11520 -4.39842  -72.04337 1.000 20.55529 ? 377 VAL   B C   1 
ATOM   4961 O  O   . VAL   B 1 377 ? -16.09590 -5.12642  -71.84682 1.000 20.54075 ? 377 VAL   B O   1 
ATOM   4962 C  CB  . VAL   B 1 377 ? -15.38476 -1.90636  -72.43297 1.000 17.66690 ? 377 VAL   B CB  1 
ATOM   4963 C  CG1 . VAL   B 1 377 ? -16.72630 -2.18333  -73.09200 1.000 14.28777 ? 377 VAL   B CG1 1 
ATOM   4964 C  CG2 . VAL   B 1 377 ? -15.40841 -0.56336  -71.73895 1.000 20.34625 ? 377 VAL   B CG2 1 
ATOM   4965 N  N   . HIS   B 1 378 ? -14.09257 -4.79206  -72.81052 1.000 23.89348 ? 378 HIS   B N   1 
ATOM   4966 C  CA  . HIS   B 1 378 ? -14.15633 -6.10538  -73.45103 1.000 25.38951 ? 378 HIS   B CA  1 
ATOM   4967 C  C   . HIS   B 1 378 ? -14.02092 -7.24728  -72.45186 1.000 23.83008 ? 378 HIS   B C   1 
ATOM   4968 O  O   . HIS   B 1 378 ? -14.79701 -8.21409  -72.55185 1.000 26.08160 ? 378 HIS   B O   1 
ATOM   4969 C  CB  . HIS   B 1 378 ? -13.11822 -6.21131  -74.57026 1.000 22.16065 ? 378 HIS   B CB  1 
ATOM   4970 C  CG  . HIS   B 1 378 ? -13.33020 -7.39689  -75.45838 1.000 26.94763 ? 378 HIS   B CG  1 
ATOM   4971 N  ND1 . HIS   B 1 378 ? -12.62686 -8.57371  -75.31442 1.000 28.41355 ? 378 HIS   B ND1 1 
ATOM   4972 C  CD2 . HIS   B 1 378 ? -14.19436 -7.59772  -76.48122 1.000 31.04431 ? 378 HIS   B CD2 1 
ATOM   4973 C  CE1 . HIS   B 1 378 ? -13.03711 -9.44245  -76.22133 1.000 27.30788 ? 378 HIS   B CE1 1 
ATOM   4974 N  NE2 . HIS   B 1 378 ? -13.98760 -8.87496  -76.94199 1.000 32.39291 ? 378 HIS   B NE2 1 
ATOM   4975 N  N   . PRO   B 1 379 ? -13.07809 -7.23074  -71.49463 1.000 22.77888 ? 379 PRO   B N   1 
ATOM   4976 C  CA  . PRO   B 1 379 ? -13.07292 -8.30125  -70.48198 1.000 19.77787 ? 379 PRO   B CA  1 
ATOM   4977 C  C   . PRO   B 1 379 ? -14.40284 -8.45254  -69.76770 1.000 23.99955 ? 379 PRO   B C   1 
ATOM   4978 O  O   . PRO   B 1 379 ? -14.84474 -9.58098  -69.52003 1.000 24.48188 ? 379 PRO   B O   1 
ATOM   4979 C  CB  . PRO   B 1 379 ? -11.96077 -7.86364  -69.52100 1.000 22.15609 ? 379 PRO   B CB  1 
ATOM   4980 C  CG  . PRO   B 1 379 ? -11.03143 -7.09027  -70.36995 1.000 22.34683 ? 379 PRO   B CG  1 
ATOM   4981 C  CD  . PRO   B 1 379 ? -11.90904 -6.34301  -71.33940 1.000 22.75239 ? 379 PRO   B CD  1 
ATOM   4982 N  N   . LEU   B 1 380 ? -15.06129 -7.33861  -69.44086 1.000 21.03640 ? 380 LEU   B N   1 
ATOM   4983 C  CA  . LEU   B 1 380 ? -16.36223 -7.41277  -68.78525 1.000 24.67566 ? 380 LEU   B CA  1 
ATOM   4984 C  C   . LEU   B 1 380 ? -17.41274 -8.01443  -69.71079 1.000 22.41433 ? 380 LEU   B C   1 
ATOM   4985 O  O   . LEU   B 1 380 ? -18.15144 -8.92558  -69.32025 1.000 20.91956 ? 380 LEU   B O   1 
ATOM   4986 C  CB  . LEU   B 1 380 ? -16.79594 -6.02440  -68.31621 1.000 18.83691 ? 380 LEU   B CB  1 
ATOM   4987 C  CG  . LEU   B 1 380 ? -18.18503 -5.97991  -67.67894 1.000 21.13723 ? 380 LEU   B CG  1 
ATOM   4988 C  CD1 . LEU   B 1 380 ? -18.23082 -6.84863  -66.43108 1.000 18.73977 ? 380 LEU   B CD1 1 
ATOM   4989 C  CD2 . LEU   B 1 380 ? -18.59630 -4.55210  -67.36196 1.000 15.67736 ? 380 LEU   B CD2 1 
ATOM   4990 N  N   . TRP   B 1 381 ? -17.49759 -7.51281  -70.94566 1.000 17.76657 ? 381 TRP   B N   1 
ATOM   4991 C  CA  . TRP   B 1 381 ? -18.52689 -7.96970  -71.87210 1.000 19.04887 ? 381 TRP   B CA  1 
ATOM   4992 C  C   . TRP   B 1 381 ? -18.23881 -9.34757  -72.45011 1.000 23.91332 ? 381 TRP   B C   1 
ATOM   4993 O  O   . TRP   B 1 381 ? -19.17275 -10.02305 -72.89466 1.000 23.38507 ? 381 TRP   B O   1 
ATOM   4994 C  CB  . TRP   B 1 381 ? -18.70929 -6.95844  -73.00421 1.000 18.54777 ? 381 TRP   B CB  1 
ATOM   4995 C  CG  . TRP   B 1 381 ? -19.62117 -5.83603  -72.62701 1.000 17.82346 ? 381 TRP   B CG  1 
ATOM   4996 C  CD1 . TRP   B 1 381 ? -19.26050 -4.57075  -72.26863 1.000 21.05106 ? 381 TRP   B CD1 1 
ATOM   4997 C  CD2 . TRP   B 1 381 ? -21.05098 -5.88464  -72.54614 1.000 18.44914 ? 381 TRP   B CD2 1 
ATOM   4998 N  NE1 . TRP   B 1 381 ? -20.37770 -3.82422  -71.98046 1.000 18.09018 ? 381 TRP   B NE1 1 
ATOM   4999 C  CE2 . TRP   B 1 381 ? -21.48959 -4.60842  -72.14248 1.000 18.69024 ? 381 TRP   B CE2 1 
ATOM   5000 C  CE3 . TRP   B 1 381 ? -22.00279 -6.88199  -72.78154 1.000 19.98158 ? 381 TRP   B CE3 1 
ATOM   5001 C  CZ2 . TRP   B 1 381 ? -22.83835 -4.30219  -71.97062 1.000 16.65166 ? 381 TRP   B CZ2 1 
ATOM   5002 C  CZ3 . TRP   B 1 381 ? -23.34131 -6.57636  -72.60914 1.000 19.56229 ? 381 TRP   B CZ3 1 
ATOM   5003 C  CH2 . TRP   B 1 381 ? -23.74633 -5.29791  -72.20673 1.000 19.93106 ? 381 TRP   B CH2 1 
ATOM   5004 N  N   . GLU   B 1 382 ? -16.97693 -9.77794  -72.46102 1.000 22.02010 ? 382 GLU   B N   1 
ATOM   5005 C  CA  . GLU   B 1 382 ? -16.67937 -11.15641 -72.83308 1.000 28.92280 ? 382 GLU   B CA  1 
ATOM   5006 C  C   . GLU   B 1 382 ? -17.16989 -12.12076 -71.76258 1.000 30.87763 ? 382 GLU   B C   1 
ATOM   5007 O  O   . GLU   B 1 382 ? -17.70737 -13.18983 -72.07586 1.000 31.27920 ? 382 GLU   B O   1 
ATOM   5008 C  CB  . GLU   B 1 382 ? -15.17833 -11.32225 -73.06225 1.000 26.07898 ? 382 GLU   B CB  1 
ATOM   5009 C  CG  . GLU   B 1 382 ? -14.76649 -12.67634 -73.60207 1.000 36.32649 ? 382 GLU   B CG  1 
ATOM   5010 C  CD  . GLU   B 1 382 ? -13.31136 -12.70396 -74.02133 1.000 41.48750 ? 382 GLU   B CD  1 
ATOM   5011 O  OE1 . GLU   B 1 382 ? -12.44978 -12.31887 -73.20256 1.000 45.93526 ? 382 GLU   B OE1 1 
ATOM   5012 O  OE2 . GLU   B 1 382 ? -13.02975 -13.09926 -75.17210 1.000 51.41230 ? 382 GLU   B OE2 1 
ATOM   5013 N  N   . THR   B 1 383 ? -16.99917 -11.75159 -70.49149 1.000 28.73641 ? 383 THR   B N   1 
ATOM   5014 C  CA  . THR   B 1 383 ? -17.49057 -12.58625 -69.40200 1.000 27.42586 ? 383 THR   B CA  1 
ATOM   5015 C  C   . THR   B 1 383 ? -19.01365 -12.59925 -69.36241 1.000 26.72737 ? 383 THR   B C   1 
ATOM   5016 O  O   . THR   B 1 383 ? -19.62492 -13.65407 -69.15340 1.000 30.68697 ? 383 THR   B O   1 
ATOM   5017 C  CB  . THR   B 1 383 ? -16.92360 -12.09490 -68.07069 1.000 27.88509 ? 383 THR   B CB  1 
ATOM   5018 O  OG1 . THR   B 1 383 ? -15.49858 -11.97696 -68.17053 1.000 21.80754 ? 383 THR   B OG1 1 
ATOM   5019 C  CG2 . THR   B 1 383 ? -17.26615 -13.07008 -66.95918 1.000 26.70643 ? 383 THR   B CG2 1 
ATOM   5020 N  N   . TRP   B 1 384 ? -19.64402 -11.43683 -69.55917 1.000 23.70170 ? 384 TRP   B N   1 
ATOM   5021 C  CA  . TRP   B 1 384 ? -21.10241 -11.38801 -69.59170 1.000 21.01322 ? 384 TRP   B CA  1 
ATOM   5022 C  C   . TRP   B 1 384 ? -21.65347 -12.19675 -70.75693 1.000 31.76501 ? 384 TRP   B C   1 
ATOM   5023 O  O   . TRP   B 1 384 ? -22.71004 -12.82918 -70.63892 1.000 27.53842 ? 384 TRP   B O   1 
ATOM   5024 C  CB  . TRP   B 1 384 ? -21.59422 -9.94329  -69.68070 1.000 19.58968 ? 384 TRP   B CB  1 
ATOM   5025 C  CG  . TRP   B 1 384 ? -23.09233 -9.86097  -69.71246 1.000 24.53695 ? 384 TRP   B CG  1 
ATOM   5026 C  CD1 . TRP   B 1 384 ? -23.89132 -9.80247  -70.81985 1.000 21.72678 ? 384 TRP   B CD1 1 
ATOM   5027 C  CD2 . TRP   B 1 384 ? -23.97289 -9.85958  -68.58313 1.000 25.04049 ? 384 TRP   B CD2 1 
ATOM   5028 N  NE1 . TRP   B 1 384 ? -25.21307 -9.75417  -70.44714 1.000 21.71938 ? 384 TRP   B NE1 1 
ATOM   5029 C  CE2 . TRP   B 1 384 ? -25.29002 -9.78719  -69.07935 1.000 25.35262 ? 384 TRP   B CE2 1 
ATOM   5030 C  CE3 . TRP   B 1 384 ? -23.77471 -9.90520  -67.19972 1.000 25.40975 ? 384 TRP   B CE3 1 
ATOM   5031 C  CZ2 . TRP   B 1 384 ? -26.40313 -9.76004  -68.24063 1.000 23.39520 ? 384 TRP   B CZ2 1 
ATOM   5032 C  CZ3 . TRP   B 1 384 ? -24.88053 -9.87794  -66.36913 1.000 17.99886 ? 384 TRP   B CZ3 1 
ATOM   5033 C  CH2 . TRP   B 1 384 ? -26.17768 -9.80681  -66.89236 1.000 22.33611 ? 384 TRP   B CH2 1 
ATOM   5034 N  N   . ALA   B 1 385 ? -20.95603 -12.17963 -71.89581 1.000 26.52534 ? 385 ALA   B N   1 
ATOM   5035 C  CA  . ALA   B 1 385 ? -21.41563 -12.94123 -73.05168 1.000 31.45177 ? 385 ALA   B CA  1 
ATOM   5036 C  C   . ALA   B 1 385 ? -21.36660 -14.43770 -72.77823 1.000 26.42180 ? 385 ALA   B C   1 
ATOM   5037 O  O   . ALA   B 1 385 ? -22.27573 -15.17352 -73.17562 1.000 32.22234 ? 385 ALA   B O   1 
ATOM   5038 C  CB  . ALA   B 1 385 ? -20.58236 -12.59046 -74.28410 1.000 24.43076 ? 385 ALA   B CB  1 
ATOM   5039 N  N   . ASP   B 1 386 ? -20.31251 -14.90637 -72.10562 1.000 26.58072 ? 386 ASP   B N   1 
ATOM   5040 C  CA  . ASP   B 1 386 ? -20.26364 -16.30073 -71.67730 1.000 31.18566 ? 386 ASP   B CA  1 
ATOM   5041 C  C   . ASP   B 1 386 ? -21.46020 -16.64199 -70.79951 1.000 35.81627 ? 386 ASP   B C   1 
ATOM   5042 O  O   . ASP   B 1 386 ? -22.10575 -17.68115 -70.97979 1.000 40.49521 ? 386 ASP   B O   1 
ATOM   5043 C  CB  . ASP   B 1 386 ? -18.96120 -16.57431 -70.92330 1.000 33.64939 ? 386 ASP   B CB  1 
ATOM   5044 C  CG  . ASP   B 1 386 ? -17.75396 -16.62511 -71.83437 1.000 39.83399 ? 386 ASP   B CG  1 
ATOM   5045 O  OD1 . ASP   B 1 386 ? -17.90083 -16.35651 -73.04532 1.000 42.06694 ? 386 ASP   B OD1 1 
ATOM   5046 O  OD2 . ASP   B 1 386 ? -16.65199 -16.92923 -71.33089 1.000 44.08444 ? 386 ASP   B OD2 1 
ATOM   5047 N  N   . LEU   B 1 387 ? -21.77535 -15.76029 -69.84665 1.000 33.21875 ? 387 LEU   B N   1 
ATOM   5048 C  CA  . LEU   B 1 387 ? -22.83629 -16.04182 -68.88525 1.000 33.44000 ? 387 LEU   B CA  1 
ATOM   5049 C  C   . LEU   B 1 387 ? -24.17875 -16.24550 -69.57706 1.000 34.02838 ? 387 LEU   B C   1 
ATOM   5050 O  O   . LEU   B 1 387 ? -24.95162 -17.13189 -69.19586 1.000 31.19312 ? 387 LEU   B O   1 
ATOM   5051 C  CB  . LEU   B 1 387 ? -22.92790 -14.90849 -67.86236 1.000 29.36167 ? 387 LEU   B CB  1 
ATOM   5052 C  CG  . LEU   B 1 387 ? -23.82742 -15.16597 -66.65068 1.000 30.52668 ? 387 LEU   B CG  1 
ATOM   5053 C  CD1 . LEU   B 1 387 ? -23.14580 -16.10040 -65.65950 1.000 28.37774 ? 387 LEU   B CD1 1 
ATOM   5054 C  CD2 . LEU   B 1 387 ? -24.23092 -13.86122 -65.97889 1.000 28.97804 ? 387 LEU   B CD2 1 
ATOM   5055 N  N   . VAL   B 1 388 ? -24.46990 -15.44671 -70.59967 1.000 30.87139 ? 388 VAL   B N   1 
ATOM   5056 C  CA  . VAL   B 1 388 ? -25.75129 -15.50270 -71.28961 1.000 28.31686 ? 388 VAL   B CA  1 
ATOM   5057 C  C   . VAL   B 1 388 ? -25.60397 -16.06300 -72.70602 1.000 29.69583 ? 388 VAL   B C   1 
ATOM   5058 O  O   . VAL   B 1 388 ? -26.49396 -15.88049 -73.53457 1.000 29.26408 ? 388 VAL   B O   1 
ATOM   5059 C  CB  . VAL   B 1 388 ? -26.43287 -14.12476 -71.30398 1.000 37.35164 ? 388 VAL   B CB  1 
ATOM   5060 C  CG1 . VAL   B 1 388 ? -26.63228 -13.61598 -69.88345 1.000 31.02333 ? 388 VAL   B CG1 1 
ATOM   5061 C  CG2 . VAL   B 1 388 ? -25.61169 -13.13690 -72.11638 1.000 29.13640 ? 388 VAL   B CG2 1 
ATOM   5062 N  N   . HIS   B 1 389 ? -24.48771 -16.73541 -72.98845 1.000 27.91600 ? 389 HIS   B N   1 
ATOM   5063 C  CA  . HIS   B 1 389 ? -24.19569 -17.37660 -74.28036 1.000 35.90491 ? 389 HIS   B CA  1 
ATOM   5064 C  C   . HIS   B 1 389 ? -25.42838 -18.04649 -74.89684 1.000 40.30496 ? 389 HIS   B C   1 
ATOM   5065 O  O   . HIS   B 1 389 ? -26.02077 -18.93076 -74.27882 1.000 39.90406 ? 389 HIS   B O   1 
ATOM   5066 C  CB  . HIS   B 1 389 ? -23.06627 -18.40168 -74.07219 1.000 33.92677 ? 389 HIS   B CB  1 
ATOM   5067 C  CG  . HIS   B 1 389 ? -22.56484 -19.04977 -75.32820 1.000 46.58309 ? 389 HIS   B CG  1 
ATOM   5068 N  ND1 . HIS   B 1 389 ? -22.91109 -18.61865 -76.58914 1.000 47.55154 ? 389 HIS   B ND1 1 
ATOM   5069 C  CD2 . HIS   B 1 389 ? -21.72662 -20.09815 -75.51030 1.000 45.01275 ? 389 HIS   B CD2 1 
ATOM   5070 C  CE1 . HIS   B 1 389 ? -22.31952 -19.37683 -77.49414 1.000 47.20979 ? 389 HIS   B CE1 1 
ATOM   5071 N  NE2 . HIS   B 1 389 ? -21.59246 -20.28187 -76.86526 1.000 48.39155 ? 389 HIS   B NE2 1 
ATOM   5072 N  N   . PRO   B 1 390 ? -25.81662 -17.64125 -76.12360 1.000 45.58305 ? 390 PRO   B N   1 
ATOM   5073 C  CA  . PRO   B 1 390 ? -25.19770 -16.69909 -77.06258 1.000 41.09735 ? 390 PRO   B CA  1 
ATOM   5074 C  C   . PRO   B 1 390 ? -25.90488 -15.36074 -77.19875 1.000 35.86400 ? 390 PRO   B C   1 
ATOM   5075 O  O   . PRO   B 1 390 ? -25.71522 -14.67577 -78.20340 1.000 34.18552 ? 390 PRO   B O   1 
ATOM   5076 C  CB  . PRO   B 1 390 ? -25.30253 -17.45427 -78.38114 1.000 36.10924 ? 390 PRO   B CB  1 
ATOM   5077 C  CG  . PRO   B 1 390 ? -26.67345 -18.09257 -78.27309 1.000 38.00158 ? 390 PRO   B CG  1 
ATOM   5078 C  CD  . PRO   B 1 390 ? -26.91042 -18.37459 -76.78568 1.000 42.52548 ? 390 PRO   B CD  1 
ATOM   5079 N  N   . ASP   B 1 391 ? -26.70975 -14.99269 -76.20627 1.000 27.31203 ? 391 ASP   B N   1 
ATOM   5080 C  CA  . ASP   B 1 391 ? -27.62549 -13.87303 -76.37317 1.000 35.54024 ? 391 ASP   B CA  1 
ATOM   5081 C  C   . ASP   B 1 391 ? -26.92944 -12.52677 -76.52766 1.000 28.47984 ? 391 ASP   B C   1 
ATOM   5082 O  O   . ASP   B 1 391 ? -27.58472 -11.56123 -76.93261 1.000 27.26184 ? 391 ASP   B O   1 
ATOM   5083 C  CB  . ASP   B 1 391 ? -28.57755 -13.81300 -75.18970 1.000 36.01658 ? 391 ASP   B CB  1 
ATOM   5084 C  CG  . ASP   B 1 391 ? -29.31950 -15.11247 -74.97125 1.000 45.17271 ? 391 ASP   B CG  1 
ATOM   5085 O  OD1 . ASP   B 1 391 ? -29.79442 -15.70458 -75.96211 1.000 47.68183 ? 391 ASP   B OD1 1 
ATOM   5086 O  OD2 . ASP   B 1 391 ? -29.43116 -15.53938 -73.80519 1.000 40.96451 ? 391 ASP   B OD2 1 
ATOM   5087 N  N   . ALA   B 1 392 ? -25.63851 -12.42821 -76.21650 1.000 28.27694 ? 392 ALA   B N   1 
ATOM   5088 C  CA  . ALA   B 1 392 ? -24.92061 -11.16257 -76.29606 1.000 34.64215 ? 392 ALA   B CA  1 
ATOM   5089 C  C   . ALA   B 1 392 ? -23.94235 -11.10972 -77.46222 1.000 26.50329 ? 392 ALA   B C   1 
ATOM   5090 O  O   . ALA   B 1 392 ? -23.08486 -10.22091 -77.49539 1.000 31.53112 ? 392 ALA   B O   1 
ATOM   5091 C  CB  . ALA   B 1 392 ? -24.18255 -10.88942 -74.98354 1.000 27.81069 ? 392 ALA   B CB  1 
ATOM   5092 N  N   . GLN   B 1 393 ? -24.05353 -12.03018 -78.42393 1.000 31.29736 ? 393 GLN   B N   1 
ATOM   5093 C  CA  . GLN   B 1 393 ? -23.07457 -12.08418 -79.50542 1.000 31.67225 ? 393 GLN   B CA  1 
ATOM   5094 C  C   . GLN   B 1 393 ? -23.09628 -10.81056 -80.34231 1.000 26.83675 ? 393 GLN   B C   1 
ATOM   5095 O  O   . GLN   B 1 393 ? -22.03934 -10.25730 -80.66716 1.000 29.35480 ? 393 GLN   B O   1 
ATOM   5096 C  CB  . GLN   B 1 393 ? -23.32456 -13.30793 -80.38577 1.000 31.58919 ? 393 GLN   B CB  1 
ATOM   5097 C  CG  . GLN   B 1 393 ? -22.14779 -13.64651 -81.27952 1.000 34.51753 ? 393 GLN   B CG  1 
ATOM   5098 C  CD  . GLN   B 1 393 ? -20.88786 -13.91386 -80.48041 1.000 34.29649 ? 393 GLN   B CD  1 
ATOM   5099 O  OE1 . GLN   B 1 393 ? -20.89203 -14.71293 -79.54399 1.000 37.41010 ? 393 GLN   B OE1 1 
ATOM   5100 N  NE2 . GLN   B 1 393 ? -19.80581 -13.22913 -80.83282 1.000 38.31633 ? 393 GLN   B NE2 1 
ATOM   5101 N  N   . ASP   B 1 394 ? -24.29026 -10.32690 -80.69662 1.000 21.80634 ? 394 ASP   B N   1 
ATOM   5102 C  CA  . ASP   B 1 394 ? -24.38564 -9.11289  -81.50252 1.000 28.00969 ? 394 ASP   B CA  1 
ATOM   5103 C  C   . ASP   B 1 394 ? -23.83124 -7.90839  -80.75302 1.000 32.22843 ? 394 ASP   B C   1 
ATOM   5104 O  O   . ASP   B 1 394 ? -23.18922 -7.03637  -81.35145 1.000 29.45862 ? 394 ASP   B O   1 
ATOM   5105 C  CB  . ASP   B 1 394 ? -25.83639 -8.86811  -81.91621 1.000 29.22741 ? 394 ASP   B CB  1 
ATOM   5106 C  CG  . ASP   B 1 394 ? -26.40546 -10.00544 -82.73964 1.000 30.13667 ? 394 ASP   B CG  1 
ATOM   5107 O  OD1 . ASP   B 1 394 ? -25.61020 -10.79693 -83.28890 1.000 37.06594 ? 394 ASP   B OD1 1 
ATOM   5108 O  OD2 . ASP   B 1 394 ? -27.64621 -10.10421 -82.84327 1.000 34.02060 ? 394 ASP   B OD2 1 
ATOM   5109 N  N   . ILE   B 1 395 ? -24.07173 -7.84156  -79.44171 1.000 30.28724 ? 395 ILE   B N   1 
ATOM   5110 C  CA  . ILE   B 1 395 ? -23.48155 -6.78043  -78.63050 1.000 26.97781 ? 395 ILE   B CA  1 
ATOM   5111 C  C   . ILE   B 1 395 ? -21.96307 -6.88860  -78.65201 1.000 24.38787 ? 395 ILE   B C   1 
ATOM   5112 O  O   . ILE   B 1 395 ? -21.25364 -5.90899  -78.91196 1.000 30.44065 ? 395 ILE   B O   1 
ATOM   5113 C  CB  . ILE   B 1 395 ? -24.02737 -6.83447  -77.19223 1.000 26.61980 ? 395 ILE   B CB  1 
ATOM   5114 C  CG1 . ILE   B 1 395 ? -25.53050 -6.54659  -77.17162 1.000 22.02233 ? 395 ILE   B CG1 1 
ATOM   5115 C  CG2 . ILE   B 1 395 ? -23.27453 -5.85826  -76.30530 1.000 21.62286 ? 395 ILE   B CG2 1 
ATOM   5116 C  CD1 . ILE   B 1 395 ? -26.16003 -6.67725  -75.79620 1.000 27.67890 ? 395 ILE   B CD1 1 
ATOM   5117 N  N   . LEU   B 1 396 ? -21.44419 -8.09002  -78.38665 1.000 20.42713 ? 396 LEU   B N   1 
ATOM   5118 C  CA  . LEU   B 1 396 ? -20.00035 -8.29661  -78.39887 1.000 22.97161 ? 396 LEU   B CA  1 
ATOM   5119 C  C   . LEU   B 1 396 ? -19.41480 -8.02539  -79.77974 1.000 28.90570 ? 396 LEU   B C   1 
ATOM   5120 O  O   . LEU   B 1 396 ? -18.31394 -7.47519  -79.89603 1.000 29.06931 ? 396 LEU   B O   1 
ATOM   5121 C  CB  . LEU   B 1 396 ? -19.67370 -9.71866  -77.94133 1.000 26.26073 ? 396 LEU   B CB  1 
ATOM   5122 C  CG  . LEU   B 1 396 ? -18.19825 -10.03926 -77.69808 1.000 27.65843 ? 396 LEU   B CG  1 
ATOM   5123 C  CD1 . LEU   B 1 396 ? -17.60655 -9.07368  -76.68497 1.000 28.46726 ? 396 LEU   B CD1 1 
ATOM   5124 C  CD2 . LEU   B 1 396 ? -18.02897 -11.47581 -77.22914 1.000 32.33389 ? 396 LEU   B CD2 1 
ATOM   5125 N  N   . ASP   B 1 397 ? -20.14038 -8.39451  -80.83894 1.000 28.03329 ? 397 ASP   B N   1 
ATOM   5126 C  CA  . ASP   B 1 397 ? -19.65657 -8.14340  -82.19403 1.000 26.23257 ? 397 ASP   B CA  1 
ATOM   5127 C  C   . ASP   B 1 397 ? -19.49651 -6.65094  -82.45343 1.000 22.71045 ? 397 ASP   B C   1 
ATOM   5128 O  O   . ASP   B 1 397 ? -18.48036 -6.21017  -83.00334 1.000 23.20501 ? 397 ASP   B O   1 
ATOM   5129 C  CB  . ASP   B 1 397 ? -20.60654 -8.76530  -83.21747 1.000 23.39561 ? 397 ASP   B CB  1 
ATOM   5130 C  CG  . ASP   B 1 397 ? -20.53336 -10.27616 -83.23519 1.000 29.35329 ? 397 ASP   B CG  1 
ATOM   5131 O  OD1 . ASP   B 1 397 ? -19.51779 -10.82780 -82.76307 1.000 27.30630 ? 397 ASP   B OD1 1 
ATOM   5132 O  OD2 . ASP   B 1 397 ? -21.49248 -10.91234 -83.71778 1.000 29.54598 ? 397 ASP   B OD2 1 
ATOM   5133 N  N   . THR   B 1 398 ? -20.49858 -5.85648  -82.06686 1.000 24.30146 ? 398 THR   B N   1 
ATOM   5134 C  CA  . THR   B 1 398 ? -20.41597 -4.41187  -82.25884 1.000 23.55225 ? 398 THR   B CA  1 
ATOM   5135 C  C   . THR   B 1 398 ? -19.23050 -3.82273  -81.50630 1.000 24.09727 ? 398 THR   B C   1 
ATOM   5136 O  O   . THR   B 1 398 ? -18.51774 -2.95974  -82.03293 1.000 23.43908 ? 398 THR   B O   1 
ATOM   5137 C  CB  . THR   B 1 398 ? -21.71296 -3.74222  -81.80541 1.000 24.72419 ? 398 THR   B CB  1 
ATOM   5138 O  OG1 . THR   B 1 398 ? -22.82559 -4.32363  -82.49593 1.000 28.50820 ? 398 THR   B OG1 1 
ATOM   5139 C  CG2 . THR   B 1 398 ? -21.66550 -2.25143  -82.09826 1.000 21.50368 ? 398 THR   B CG2 1 
ATOM   5140 N  N   . LEU   B 1 399 ? -19.00784 -4.27817  -80.27087 1.000 25.49443 ? 399 LEU   B N   1 
ATOM   5141 C  CA  . LEU   B 1 399 ? -17.88006 -3.79525  -79.48005 1.000 23.65151 ? 399 LEU   B CA  1 
ATOM   5142 C  C   . LEU   B 1 399 ? -16.56008 -4.02492  -80.20462 1.000 24.90200 ? 399 LEU   B C   1 
ATOM   5143 O  O   . LEU   B 1 399 ? -15.71202 -3.12786  -80.27750 1.000 21.98365 ? 399 LEU   B O   1 
ATOM   5144 C  CB  . LEU   B 1 399 ? -17.87118 -4.48793  -78.11734 1.000 19.58817 ? 399 LEU   B CB  1 
ATOM   5145 C  CG  . LEU   B 1 399 ? -16.65365 -4.25146  -77.22480 1.000 26.92280 ? 399 LEU   B CG  1 
ATOM   5146 C  CD1 . LEU   B 1 399 ? -16.54972 -2.78962  -76.84623 1.000 20.76352 ? 399 LEU   B CD1 1 
ATOM   5147 C  CD2 . LEU   B 1 399 ? -16.72806 -5.12455  -75.98511 1.000 20.11560 ? 399 LEU   B CD2 1 
ATOM   5148 N  N   . GLU   B 1 400 ? -16.37125 -5.22604  -80.75371 1.000 21.65578 ? 400 GLU   B N   1 
ATOM   5149 C  CA  . GLU   B 1 400 ? -15.11001 -5.54338  -81.41295 1.000 23.54141 ? 400 GLU   B CA  1 
ATOM   5150 C  C   . GLU   B 1 400 ? -14.96471 -4.80296  -82.73771 1.000 19.90034 ? 400 GLU   B C   1 
ATOM   5151 O  O   . GLU   B 1 400 ? -13.84517 -4.45026  -83.12560 1.000 22.07166 ? 400 GLU   B O   1 
ATOM   5152 C  CB  . GLU   B 1 400 ? -14.99855 -7.05656  -81.60225 1.000 25.40444 ? 400 GLU   B CB  1 
ATOM   5153 C  CG  . GLU   B 1 400 ? -15.22734 -7.81711  -80.29950 1.000 30.73654 ? 400 GLU   B CG  1 
ATOM   5154 C  CD  . GLU   B 1 400 ? -15.05064 -9.31829  -80.42566 1.000 35.42090 ? 400 GLU   B CD  1 
ATOM   5155 O  OE1 . GLU   B 1 400 ? -14.62997 -9.94553  -79.43005 1.000 30.33515 ? 400 GLU   B OE1 1 
ATOM   5156 O  OE2 . GLU   B 1 400 ? -15.33638 -9.87213  -81.50800 1.000 33.73306 ? 400 GLU   B OE2 1 
ATOM   5157 N  N   . ASP   B 1 401 ? -16.07424 -4.54880  -83.43735 1.000 22.72743 ? 401 ASP   B N   1 
ATOM   5158 C  CA  . ASP   B 1 401 ? -16.02316 -3.68812  -84.61661 1.000 21.90813 ? 401 ASP   B CA  1 
ATOM   5159 C  C   . ASP   B 1 401 ? -15.60682 -2.27252  -84.23853 1.000 24.02377 ? 401 ASP   B C   1 
ATOM   5160 O  O   . ASP   B 1 401 ? -14.76562 -1.65806  -84.90525 1.000 17.33815 ? 401 ASP   B O   1 
ATOM   5161 C  CB  . ASP   B 1 401 ? -17.38096 -3.66398  -85.32065 1.000 22.35659 ? 401 ASP   B CB  1 
ATOM   5162 C  CG  . ASP   B 1 401 ? -17.75849 -5.00317  -85.91308 1.000 26.18463 ? 401 ASP   B CG  1 
ATOM   5163 O  OD1 . ASP   B 1 401 ? -16.88308 -5.88916  -85.98851 1.000 20.45044 ? 401 ASP   B OD1 1 
ATOM   5164 O  OD2 . ASP   B 1 401 ? -18.93088 -5.16371  -86.31379 1.000 22.17550 ? 401 ASP   B OD2 1 
ATOM   5165 N  N   . ASN   B 1 402 ? -16.20032 -1.73381  -83.17047 1.000 21.30163 ? 402 ASN   B N   1 
ATOM   5166 C  CA  . ASN   B 1 402 ? -15.89152 -0.36884  -82.75707 1.000 22.13832 ? 402 ASN   B CA  1 
ATOM   5167 C  C   . ASN   B 1 402 ? -14.45353 -0.25101  -82.27053 1.000 18.56861 ? 402 ASN   B C   1 
ATOM   5168 O  O   . ASN   B 1 402 ? -13.78929 0.76264   -82.51822 1.000 16.57771 ? 402 ASN   B O   1 
ATOM   5169 C  CB  . ASN   B 1 402 ? -16.86603 0.08035   -81.66937 1.000 18.23259 ? 402 ASN   B CB  1 
ATOM   5170 C  CG  . ASN   B 1 402 ? -18.28199 0.24518   -82.18663 1.000 22.60941 ? 402 ASN   B CG  1 
ATOM   5171 O  OD1 . ASN   B 1 402 ? -18.50053 0.44849   -83.38137 1.000 21.76069 ? 402 ASN   B OD1 1 
ATOM   5172 N  ND2 . ASN   B 1 402 ? -19.25371 0.15901   -81.28560 1.000 20.62136 ? 402 ASN   B ND2 1 
ATOM   5173 N  N   . ARG   B 1 403 ? -13.96077 -1.27391  -81.56915 1.000 16.93328 ? 403 ARG   B N   1 
ATOM   5174 C  CA  . ARG   B 1 403 ? -12.55960 -1.29355  -81.16374 1.000 17.21465 ? 403 ARG   B CA  1 
ATOM   5175 C  C   . ARG   B 1 403 ? -11.64641 -1.25318  -82.38151 1.000 19.56110 ? 403 ARG   B C   1 
ATOM   5176 O  O   . ARG   B 1 403 ? -10.67151 -0.49323  -82.42021 1.000 17.24257 ? 403 ARG   B O   1 
ATOM   5177 C  CB  . ARG   B 1 403 ? -12.28432 -2.53876  -80.31850 1.000 18.66917 ? 403 ARG   B CB  1 
ATOM   5178 C  CG  . ARG   B 1 403 ? -10.94909 -2.54031  -79.59145 1.000 19.23566 ? 403 ARG   B CG  1 
ATOM   5179 C  CD  . ARG   B 1 403 ? -9.84758  -3.17258  -80.41679 1.000 20.45411 ? 403 ARG   B CD  1 
ATOM   5180 N  NE  . ARG   B 1 403 ? -8.64338  -3.39454  -79.62596 1.000 22.73146 ? 403 ARG   B NE  1 
ATOM   5181 C  CZ  . ARG   B 1 403 ? -7.41406  -3.40044  -80.12810 1.000 21.51868 ? 403 ARG   B CZ  1 
ATOM   5182 N  NH1 . ARG   B 1 403 ? -7.22471  -3.18624  -81.42282 1.000 22.07092 ? 403 ARG   B NH1 1 
ATOM   5183 N  NH2 . ARG   B 1 403 ? -6.37373  -3.61378  -79.33571 1.000 22.70907 ? 403 ARG   B NH2 1 
ATOM   5184 N  N   . GLU   B 1 404 ? -11.95183 -2.07369  -83.38898 1.000 20.21978 ? 404 GLU   B N   1 
ATOM   5185 C  CA  . GLU   B 1 404 ? -11.15462 -2.08747  -84.61027 1.000 21.18986 ? 404 GLU   B CA  1 
ATOM   5186 C  C   . GLU   B 1 404 ? -11.19179 -0.73567  -85.31097 1.000 15.71936 ? 404 GLU   B C   1 
ATOM   5187 O  O   . GLU   B 1 404 ? -10.16457 -0.25726  -85.80619 1.000 15.10968 ? 404 GLU   B O   1 
ATOM   5188 C  CB  . GLU   B 1 404 ? -11.65404 -3.19332  -85.54019 1.000 20.97386 ? 404 GLU   B CB  1 
ATOM   5189 C  CG  . GLU   B 1 404 ? -11.02849 -3.19523  -86.92499 1.000 21.97946 ? 404 GLU   B CG  1 
ATOM   5190 C  CD  . GLU   B 1 404 ? -11.51221 -4.35755  -87.77342 1.000 28.28329 ? 404 GLU   B CD  1 
ATOM   5191 O  OE1 . GLU   B 1 404 ? -10.66683 -5.15289  -88.23517 1.000 33.35275 ? 404 GLU   B OE1 1 
ATOM   5192 O  OE2 . GLU   B 1 404 ? -12.74011 -4.48236  -87.96831 1.000 21.58319 ? 404 GLU   B OE2 1 
ATOM   5193 N  N   . TRP   B 1 405 ? -12.36553 -0.10224  -85.36102 1.000 15.71211 ? 405 TRP   B N   1 
ATOM   5194 C  CA  . TRP   B 1 405 ? -12.46806 1.20312   -86.00490 1.000 17.51041 ? 405 TRP   B CA  1 
ATOM   5195 C  C   . TRP   B 1 405 ? -11.62721 2.24263   -85.27642 1.000 19.06131 ? 405 TRP   B C   1 
ATOM   5196 O  O   . TRP   B 1 405 ? -10.85718 2.98295   -85.89953 1.000 15.27828 ? 405 TRP   B O   1 
ATOM   5197 C  CB  . TRP   B 1 405 ? -13.92555 1.65399   -86.06953 1.000 16.57583 ? 405 TRP   B CB  1 
ATOM   5198 C  CG  . TRP   B 1 405 ? -14.08124 2.96531   -86.77044 1.000 20.61717 ? 405 TRP   B CG  1 
ATOM   5199 C  CD1 . TRP   B 1 405 ? -14.19565 3.16601   -88.11474 1.000 19.68962 ? 405 TRP   B CD1 1 
ATOM   5200 C  CD2 . TRP   B 1 405 ? -14.11402 4.26426   -86.16594 1.000 15.83137 ? 405 TRP   B CD2 1 
ATOM   5201 N  NE1 . TRP   B 1 405 ? -14.30980 4.50865   -88.38500 1.000 20.58576 ? 405 TRP   B NE1 1 
ATOM   5202 C  CE2 . TRP   B 1 405 ? -14.26259 5.20434   -87.20544 1.000 20.14568 ? 405 TRP   B CE2 1 
ATOM   5203 C  CE3 . TRP   B 1 405 ? -14.03897 4.72295   -84.84668 1.000 16.19547 ? 405 TRP   B CE3 1 
ATOM   5204 C  CZ2 . TRP   B 1 405 ? -14.33718 6.57579   -86.96731 1.000 17.94839 ? 405 TRP   B CZ2 1 
ATOM   5205 C  CZ3 . TRP   B 1 405 ? -14.11362 6.08550   -84.61228 1.000 19.49359 ? 405 TRP   B CZ3 1 
ATOM   5206 C  CH2 . TRP   B 1 405 ? -14.25986 6.99507   -85.66765 1.000 16.19052 ? 405 TRP   B CH2 1 
ATOM   5207 N  N   . TYR   B 1 406 ? -11.77030 2.31973   -83.95128 1.000 15.59330 ? 406 TYR   B N   1 
ATOM   5208 C  CA  . TYR   B 1 406 ? -11.01047 3.30383   -83.18832 1.000 15.49892 ? 406 TYR   B CA  1 
ATOM   5209 C  C   . TYR   B 1 406 ? -9.51301  3.07966   -83.33393 1.000 18.12505 ? 406 TYR   B C   1 
ATOM   5210 O  O   . TYR   B 1 406 ? -8.74437  4.04011   -83.46084 1.000 15.48935 ? 406 TYR   B O   1 
ATOM   5211 C  CB  . TYR   B 1 406 ? -11.42034 3.26430   -81.71882 1.000 17.30418 ? 406 TYR   B CB  1 
ATOM   5212 C  CG  . TYR   B 1 406 ? -12.36250 4.37757   -81.34102 1.000 16.05223 ? 406 TYR   B CG  1 
ATOM   5213 C  CD1 . TYR   B 1 406 ? -11.91699 5.69060   -81.27161 1.000 15.41664 ? 406 TYR   B CD1 1 
ATOM   5214 C  CD2 . TYR   B 1 406 ? -13.69558 4.12039   -81.05947 1.000 14.55919 ? 406 TYR   B CD2 1 
ATOM   5215 C  CE1 . TYR   B 1 406 ? -12.77158 6.71534   -80.92925 1.000 15.76443 ? 406 TYR   B CE1 1 
ATOM   5216 C  CE2 . TYR   B 1 406 ? -14.55817 5.13972   -80.71552 1.000 14.89043 ? 406 TYR   B CE2 1 
ATOM   5217 C  CZ  . TYR   B 1 406 ? -14.08995 6.43512   -80.65147 1.000 15.43964 ? 406 TYR   B CZ  1 
ATOM   5218 O  OH  . TYR   B 1 406 ? -14.94477 7.45562   -80.30902 1.000 17.51234 ? 406 TYR   B OH  1 
ATOM   5219 N  N   . GLN   B 1 407 ? -9.08005  1.81746   -83.32216 1.000 16.21651 ? 407 GLN   B N   1 
ATOM   5220 C  CA  . GLN   B 1 407 ? -7.67371  1.52159   -83.56859 1.000 16.85288 ? 407 GLN   B CA  1 
ATOM   5221 C  C   . GLN   B 1 407 ? -7.22945  2.05660   -84.92418 1.000 18.00724 ? 407 GLN   B C   1 
ATOM   5222 O  O   . GLN   B 1 407 ? -6.12490  2.59695   -85.05582 1.000 19.22374 ? 407 GLN   B O   1 
ATOM   5223 C  CB  . GLN   B 1 407 ? -7.43136  0.01524   -83.48263 1.000 18.10723 ? 407 GLN   B CB  1 
ATOM   5224 C  CG  . GLN   B 1 407 ? -5.97245  -0.38122  -83.63116 1.000 21.27062 ? 407 GLN   B CG  1 
ATOM   5225 C  CD  . GLN   B 1 407 ? -5.09730  0.20581   -82.54100 1.000 29.68087 ? 407 GLN   B CD  1 
ATOM   5226 O  OE1 . GLN   B 1 407 ? -5.50502  0.29027   -81.38282 1.000 22.02592 ? 407 GLN   B OE1 1 
ATOM   5227 N  NE2 . GLN   B 1 407 ? -3.88859  0.61997   -82.90744 1.000 22.39735 ? 407 GLN   B NE2 1 
ATOM   5228 N  N   . SER   B 1 408 ? -8.08553  1.93368   -85.94119 1.000 14.93717 ? 408 SER   B N   1 
ATOM   5229 C  CA  . SER   B 1 408 ? -7.70894  2.35917   -87.28359 1.000 16.48422 ? 408 SER   B CA  1 
ATOM   5230 C  C   . SER   B 1 408 ? -7.59257  3.87246   -87.41204 1.000 14.84788 ? 408 SER   B C   1 
ATOM   5231 O  O   . SER   B 1 408 ? -6.96104  4.34962   -88.36054 1.000 13.39774 ? 408 SER   B O   1 
ATOM   5232 C  CB  . SER   B 1 408 ? -8.71296  1.83062   -88.30499 1.000 16.82188 ? 408 SER   B CB  1 
ATOM   5233 O  OG  . SER   B 1 408 ? -9.92436  2.56385   -88.26192 1.000 12.34537 ? 408 SER   B OG  1 
ATOM   5234 N  N   . THR   B 1 409 ? -8.18521  4.63617   -86.49427 1.000 12.51422 ? 409 THR   B N   1 
ATOM   5235 C  CA  . THR   B 1 409 ? -8.00948  6.08343   -86.49080 1.000 16.55993 ? 409 THR   B CA  1 
ATOM   5236 C  C   . THR   B 1 409 ? -6.66188  6.50999   -85.92435 1.000 15.50716 ? 409 THR   B C   1 
ATOM   5237 O  O   . THR   B 1 409 ? -6.33883  7.70201   -85.96814 1.000 12.10684 ? 409 THR   B O   1 
ATOM   5238 C  CB  . THR   B 1 409 ? -9.12738  6.75886   -85.69297 1.000 15.79242 ? 409 THR   B CB  1 
ATOM   5239 O  OG1 . THR   B 1 409 ? -8.97291  6.44733   -84.30472 1.000 20.33697 ? 409 THR   B OG1 1 
ATOM   5240 C  CG2 . THR   B 1 409 ? -10.48937 6.27868   -86.16433 1.000 12.56018 ? 409 THR   B CG2 1 
ATOM   5241 N  N   . ILE   B 1 410 ? -5.87776  5.57573   -85.39560 1.000 17.50276 ? 410 ILE   B N   1 
ATOM   5242 C  CA  . ILE   B 1 410 ? -4.55610  5.88164   -84.86368 1.000 18.14788 ? 410 ILE   B CA  1 
ATOM   5243 C  C   . ILE   B 1 410 ? -3.49303  5.63896   -85.93032 1.000 17.02469 ? 410 ILE   B C   1 
ATOM   5244 O  O   . ILE   B 1 410 ? -3.29855  4.50948   -86.38248 1.000 16.65823 ? 410 ILE   B O   1 
ATOM   5245 C  CB  . ILE   B 1 410 ? -4.26095  5.05352   -83.60075 1.000 20.05634 ? 410 ILE   B CB  1 
ATOM   5246 C  CG1 . ILE   B 1 410 ? -5.34105  5.29090   -82.54483 1.000 17.33271 ? 410 ILE   B CG1 1 
ATOM   5247 C  CG2 . ILE   B 1 410 ? -2.89432  5.40787   -83.04032 1.000 16.48104 ? 410 ILE   B CG2 1 
ATOM   5248 C  CD1 . ILE   B 1 410 ? -5.45829  4.17527   -81.53026 1.000 19.30864 ? 410 ILE   B CD1 1 
HETATM 5249 ZN ZN  . ZN    C 2 .   ? -19.04850 3.46838   -28.48970 1.000 16.22547 ? 601 ZN    A ZN  1 
HETATM 5250 MG MG  . MG    D 3 .   ? -20.64901 3.46951   -31.78056 1.000 10.44522 ? 602 MG    A MG  1 
HETATM 5251 C  C10 . A1D8O E 4 .   ? -23.86044 -1.69471  -29.84464 1.000 38.70768 ? 603 A1D8O A C10 1 
HETATM 5252 C  C12 . A1D8O E 4 .   ? -22.82775 -1.50790  -26.44710 1.000 26.95141 ? 603 A1D8O A C12 1 
HETATM 5253 C  C13 . A1D8O E 4 .   ? -23.10088 -1.87749  -25.05407 1.000 24.39446 ? 603 A1D8O A C13 1 
HETATM 5254 C  C14 . A1D8O E 4 .   ? -22.37820 -1.16475  -24.09926 1.000 25.81626 ? 603 A1D8O A C14 1 
HETATM 5255 C  C15 . A1D8O E 4 .   ? -22.50215 -1.43747  -22.74917 1.000 22.11178 ? 603 A1D8O A C15 1 
HETATM 5256 C  C16 . A1D8O E 4 .   ? -23.36119 -2.43918  -22.32991 1.000 16.50157 ? 603 A1D8O A C16 1 
HETATM 5257 O  O1  . A1D8O E 4 .   ? -25.59700 -2.88269  -27.20327 1.000 42.80457 ? 603 A1D8O A O1  1 
HETATM 5258 C  C2  . A1D8O E 4 .   ? -24.77196 -2.37331  -27.91921 1.000 35.74904 ? 603 A1D8O A C2  1 
HETATM 5259 C  C3  . A1D8O E 4 .   ? -23.47243 -1.75317  -27.59973 1.000 32.75929 ? 603 A1D8O A C3  1 
HETATM 5260 C  C4  . A1D8O E 4 .   ? -22.92848 -1.33090  -28.87810 1.000 24.47602 ? 603 A1D8O A C4  1 
HETATM 5261 C  C5  . A1D8O E 4 .   ? -21.75973 -0.70214  -29.30029 1.000 24.67409 ? 603 A1D8O A C5  1 
HETATM 5262 C  C6  . A1D8O E 4 .   ? -21.55135 -0.44759  -30.64717 1.000 23.40955 ? 603 A1D8O A C6  1 
HETATM 5263 C  C7  . A1D8O E 4 .   ? -22.50818 -0.82163  -31.58812 1.000 32.57532 ? 603 A1D8O A C7  1 
HETATM 5264 O  O8  . A1D8O E 4 .   ? -22.28227 -0.58280  -32.91320 1.000 30.24355 ? 603 A1D8O A O8  1 
HETATM 5265 C  C9  . A1D8O E 4 .   ? -23.68184 -1.45133  -31.18939 1.000 32.27677 ? 603 A1D8O A C9  1 
HETATM 5266 O  O11 . A1D8O E 4 .   ? -24.96509 -2.31445  -29.28151 1.000 38.22455 ? 603 A1D8O A O11 1 
HETATM 5267 O  O17 . A1D8O E 4 .   ? -23.53702 -2.81224  -21.02859 1.000 23.08437 ? 603 A1D8O A O17 1 
HETATM 5268 C  C18 . A1D8O E 4 .   ? -22.71650 -2.18286  -20.04712 1.000 17.63254 ? 603 A1D8O A C18 1 
HETATM 5269 C  C19 . A1D8O E 4 .   ? -24.10199 -3.17100  -23.27613 1.000 21.39017 ? 603 A1D8O A C19 1 
HETATM 5270 O  O20 . A1D8O E 4 .   ? -24.92247 -4.14036  -22.75756 1.000 19.23426 ? 603 A1D8O A O20 1 
HETATM 5271 C  C21 . A1D8O E 4 .   ? -25.72340 -4.92690  -23.64916 1.000 21.82877 ? 603 A1D8O A C21 1 
HETATM 5272 C  C22 . A1D8O E 4 .   ? -26.49214 -5.89732  -22.81905 1.000 26.94920 ? 603 A1D8O A C22 1 
HETATM 5273 C  C23 . A1D8O E 4 .   ? -23.96929 -2.88837  -24.62585 1.000 22.52389 ? 603 A1D8O A C23 1 
HETATM 5274 ZN ZN  . ZN    F 2 .   ? -23.04816 5.87822   -64.93591 1.000 19.44922 ? 601 ZN    B ZN  1 
HETATM 5275 MG MG  . MG    G 3 .   ? -21.60178 6.47827   -61.64579 1.000 11.59521 ? 602 MG    B MG  1 
HETATM 5276 C  C10 . A1D8O H 4 .   ? -13.77335 5.80635   -65.44855 1.000 46.09787 ? 603 A1D8O B C10 1 
HETATM 5277 C  C12 . A1D8O H 4 .   ? -16.54254 6.19473   -67.74097 1.000 37.08544 ? 603 A1D8O B C12 1 
HETATM 5278 C  C13 . A1D8O H 4 .   ? -16.47060 6.25313   -69.20284 1.000 31.76025 ? 603 A1D8O B C13 1 
HETATM 5279 C  C14 . A1D8O H 4 .   ? -17.62332 6.28314   -69.98624 1.000 23.73985 ? 603 A1D8O B C14 1 
HETATM 5280 C  C15 . A1D8O H 4 .   ? -17.55342 6.33286   -71.36770 1.000 19.83299 ? 603 A1D8O B C15 1 
HETATM 5281 C  C16 . A1D8O H 4 .   ? -16.31421 6.35408   -71.98923 1.000 20.55726 ? 603 A1D8O B C16 1 
HETATM 5282 O  O1  . A1D8O H 4 .   ? -16.77229 7.31173   -65.08289 1.000 45.85993 ? 603 A1D8O B O1  1 
HETATM 5283 C  C2  . A1D8O H 4 .   ? -15.81088 6.71989   -65.50689 1.000 43.71909 ? 603 A1D8O B C2  1 
HETATM 5284 C  C3  . A1D8O H 4 .   ? -15.56236 6.11076   -66.82485 1.000 39.86821 ? 603 A1D8O B C3  1 
HETATM 5285 C  C4  . A1D8O H 4 .   ? -14.23013 5.53534   -66.73417 1.000 41.09214 ? 603 A1D8O B C4  1 
HETATM 5286 C  C5  . A1D8O H 4 .   ? -13.39499 4.81736   -67.58556 1.000 40.16895 ? 603 A1D8O B C5  1 
HETATM 5287 C  C6  . A1D8O H 4 .   ? -12.14819 4.39485   -67.14960 1.000 42.95251 ? 603 A1D8O B C6  1 
HETATM 5288 C  C7  . A1D8O H 4 .   ? -11.72263 4.68514   -65.85540 1.000 48.70319 ? 603 A1D8O B C7  1 
HETATM 5289 O  O8  . A1D8O H 4 .   ? -10.49852 4.25659   -65.42959 1.000 54.77078 ? 603 A1D8O B O8  1 
HETATM 5290 C  C9  . A1D8O H 4 .   ? -12.53899 5.40033   -64.98805 1.000 50.31924 ? 603 A1D8O B C9  1 
HETATM 5291 O  O11 . A1D8O H 4 .   ? -14.70757 6.51368   -64.70955 1.000 51.24766 ? 603 A1D8O B O11 1 
HETATM 5292 O  O17 . A1D8O H 4 .   ? -16.12421 6.42262   -73.33939 1.000 27.49588 ? 603 A1D8O B O17 1 
HETATM 5293 C  C18 . A1D8O H 4 .   ? -17.28101 6.55363   -74.16179 1.000 21.73690 ? 603 A1D8O B C18 1 
HETATM 5294 C  C19 . A1D8O H 4 .   ? -15.14086 6.32433   -71.21421 1.000 23.16320 ? 603 A1D8O B C19 1 
HETATM 5295 O  O20 . A1D8O H 4 .   ? -13.95341 6.34512   -71.89426 1.000 22.68118 ? 603 A1D8O B O20 1 
HETATM 5296 C  C21 . A1D8O H 4 .   ? -12.74320 6.37850   -71.12592 1.000 23.02209 ? 603 A1D8O B C21 1 
HETATM 5297 C  C22 . A1D8O H 4 .   ? -11.61166 6.26787   -72.06703 1.000 21.20298 ? 603 A1D8O B C22 1 
HETATM 5298 C  C23 . A1D8O H 4 .   ? -15.22603 6.27494   -69.83647 1.000 29.99022 ? 603 A1D8O B C23 1 
HETATM 5299 O  O   . HOH   I 5 .   ? -0.207    19.749    -43.821   1.000 39.93486 ? 701 HOH   A O   1 
HETATM 5300 O  O   . HOH   I 5 .   ? -30.18037 13.51203  -28.06002 1.000 27.23349 ? 702 HOH   A O   1 
HETATM 5301 O  O   . HOH   I 5 .   ? -12.65436 4.08538   -16.27661 1.000 16.96602 ? 703 HOH   A O   1 
HETATM 5302 O  O   . HOH   I 5 .   ? -32.48634 -1.64590  -32.35095 1.000 22.36610 ? 704 HOH   A O   1 
HETATM 5303 O  O   . HOH   I 5 .   ? -0.12445  25.80101  -38.92082 1.000 25.92285 ? 705 HOH   A O   1 
HETATM 5304 O  O   . HOH   I 5 .   ? -9.58885  -5.17262  -40.88895 1.000 16.37806 ? 706 HOH   A O   1 
HETATM 5305 O  O   . HOH   I 5 .   ? -18.14798 4.74380   -45.31315 1.000 16.73503 ? 707 HOH   A O   1 
HETATM 5306 O  O   . HOH   I 5 .   ? 2.13793   -8.61454  -40.08526 1.000 29.56769 ? 708 HOH   A O   1 
HETATM 5307 O  O   . HOH   I 5 .   ? -3.227    -24.780   -34.032   1.000 23.15935 ? 709 HOH   A O   1 
HETATM 5308 O  O   . HOH   I 5 .   ? -15.719   3.629     -9.191    1.000 43.50265 ? 710 HOH   A O   1 
HETATM 5309 O  O   . HOH   I 5 .   ? -3.90782  -13.66511 -20.72206 1.000 22.81745 ? 711 HOH   A O   1 
HETATM 5310 O  O   . HOH   I 5 .   ? 2.72539   -0.78384  -26.15727 1.000 21.84312 ? 712 HOH   A O   1 
HETATM 5311 O  O   . HOH   I 5 .   ? 11.34178  -5.44021  -31.74860 1.000 40.79626 ? 713 HOH   A O   1 
HETATM 5312 O  O   . HOH   I 5 .   ? -9.29148  28.19930  -37.65985 1.000 31.04400 ? 714 HOH   A O   1 
HETATM 5313 O  O   . HOH   I 5 .   ? -23.49798 13.14809  -41.38726 1.000 11.60798 ? 715 HOH   A O   1 
HETATM 5314 O  O   . HOH   I 5 .   ? -26.78799 -3.75256  -13.32987 1.000 21.37611 ? 716 HOH   A O   1 
HETATM 5315 O  O   . HOH   I 5 .   ? -6.25587  -15.66047 -23.06528 1.000 31.63372 ? 717 HOH   A O   1 
HETATM 5316 O  O   . HOH   I 5 .   ? -14.95872 0.78125   -20.15350 1.000 10.74462 ? 718 HOH   A O   1 
HETATM 5317 O  O   . HOH   I 5 .   ? 1.812     -17.977   -34.212   1.000 39.24310 ? 719 HOH   A O   1 
HETATM 5318 O  O   . HOH   I 5 .   ? -9.23061  8.24918   -11.29821 1.000 23.42866 ? 720 HOH   A O   1 
HETATM 5319 O  O   . HOH   I 5 .   ? -18.05091 3.51871   -21.76052 1.000 7.83716  ? 721 HOH   A O   1 
HETATM 5320 O  O   . HOH   I 5 .   ? -17.59696 -1.38491  -31.23605 1.000 9.55150  ? 722 HOH   A O   1 
HETATM 5321 O  O   . HOH   I 5 .   ? -22.82590 14.81189  -20.82520 1.000 21.50234 ? 723 HOH   A O   1 
HETATM 5322 O  O   . HOH   I 5 .   ? -24.41023 -1.38104  -40.27206 1.000 16.32127 ? 724 HOH   A O   1 
HETATM 5323 O  O   . HOH   I 5 .   ? -1.75537  6.55842   -14.25663 1.000 20.92536 ? 725 HOH   A O   1 
HETATM 5324 O  O   . HOH   I 5 .   ? -27.05465 12.20260  -20.32931 1.000 21.72564 ? 726 HOH   A O   1 
HETATM 5325 O  O   . HOH   I 5 .   ? 3.28399   0.92081   -29.94368 1.000 17.54124 ? 727 HOH   A O   1 
HETATM 5326 O  O   . HOH   I 5 .   ? -26.61648 -1.78894  -11.77866 1.000 21.31830 ? 728 HOH   A O   1 
HETATM 5327 O  O   . HOH   I 5 .   ? -10.11343 25.10976  -38.50746 1.000 23.78040 ? 729 HOH   A O   1 
HETATM 5328 O  O   . HOH   I 5 .   ? -28.68111 -1.82166  -14.43929 1.000 20.53899 ? 730 HOH   A O   1 
HETATM 5329 O  O   . HOH   I 5 .   ? -33.66406 3.45933   -44.10831 1.000 18.24942 ? 731 HOH   A O   1 
HETATM 5330 O  O   . HOH   I 5 .   ? -30.83942 2.47789   -27.79302 1.000 19.44844 ? 732 HOH   A O   1 
HETATM 5331 O  O   . HOH   I 5 .   ? -19.39189 2.72640   -30.38170 1.000 9.36881  ? 733 HOH   A O   1 
HETATM 5332 O  O   . HOH   I 5 .   ? -16.12567 25.70605  -31.92675 1.000 26.60380 ? 734 HOH   A O   1 
HETATM 5333 O  O   . HOH   I 5 .   ? -22.87984 19.85445  -19.31389 1.000 28.99990 ? 735 HOH   A O   1 
HETATM 5334 O  O   . HOH   I 5 .   ? -20.72992 1.77287   -32.99418 1.000 12.12104 ? 736 HOH   A O   1 
HETATM 5335 O  O   . HOH   I 5 .   ? -10.59724 -7.57728  -40.00831 1.000 22.75296 ? 737 HOH   A O   1 
HETATM 5336 O  O   . HOH   I 5 .   ? -11.93160 18.08879  -41.77591 1.000 19.32403 ? 738 HOH   A O   1 
HETATM 5337 O  O   . HOH   I 5 .   ? -14.21599 27.29800  -32.64262 1.000 30.00612 ? 739 HOH   A O   1 
HETATM 5338 O  O   . HOH   I 5 .   ? 2.30054   17.20963  -26.05272 1.000 39.89124 ? 740 HOH   A O   1 
HETATM 5339 O  O   . HOH   I 5 .   ? -35.77708 8.29279   -36.63856 1.000 20.93136 ? 741 HOH   A O   1 
HETATM 5340 O  O   . HOH   I 5 .   ? -25.18986 -1.66600  -36.52489 1.000 12.33258 ? 742 HOH   A O   1 
HETATM 5341 O  O   . HOH   I 5 .   ? -19.22684 4.04397   -33.23132 1.000 10.72265 ? 743 HOH   A O   1 
HETATM 5342 O  O   . HOH   I 5 .   ? -32.37027 6.11577   -26.17083 1.000 18.68247 ? 744 HOH   A O   1 
HETATM 5343 O  O   . HOH   I 5 .   ? -0.98903  2.04472   -19.16378 1.000 22.69926 ? 745 HOH   A O   1 
HETATM 5344 O  O   . HOH   I 5 .   ? -28.47124 3.21902   -28.66589 1.000 17.31815 ? 746 HOH   A O   1 
HETATM 5345 O  O   . HOH   I 5 .   ? -16.075   28.111    -36.306   1.000 24.16456 ? 747 HOH   A O   1 
HETATM 5346 O  O   . HOH   I 5 .   ? -12.95047 -0.27198  -33.90085 1.000 22.45740 ? 748 HOH   A O   1 
HETATM 5347 O  O   . HOH   I 5 .   ? -7.09747  9.31892   -46.71809 1.000 15.25773 ? 749 HOH   A O   1 
HETATM 5348 O  O   . HOH   I 5 .   ? -10.45973 2.61869   -17.32062 1.000 18.05236 ? 750 HOH   A O   1 
HETATM 5349 O  O   . HOH   I 5 .   ? -7.26552  -5.64094  -42.02959 1.000 25.05202 ? 751 HOH   A O   1 
HETATM 5350 O  O   . HOH   I 5 .   ? -18.35783 -12.89357 -30.43113 1.000 18.76170 ? 752 HOH   A O   1 
HETATM 5351 O  O   . HOH   I 5 .   ? -30.81146 6.01107   -48.90631 1.000 15.35087 ? 753 HOH   A O   1 
HETATM 5352 O  O   . HOH   I 5 .   ? -24.15744 11.73836  -28.43284 1.000 9.66873  ? 754 HOH   A O   1 
HETATM 5353 O  O   . HOH   I 5 .   ? -12.18466 -8.89748  -10.62843 1.000 24.59759 ? 755 HOH   A O   1 
HETATM 5354 O  O   . HOH   I 5 .   ? -19.36962 23.78977  -29.88902 1.000 31.47832 ? 756 HOH   A O   1 
HETATM 5355 O  O   . HOH   I 5 .   ? 5.14036   2.50457   -30.40369 1.000 27.97947 ? 757 HOH   A O   1 
HETATM 5356 O  O   . HOH   I 5 .   ? -11.69809 1.86231   -10.08456 1.000 21.80254 ? 758 HOH   A O   1 
HETATM 5357 O  O   . HOH   I 5 .   ? -31.00778 -1.47400  -47.03095 1.000 14.84169 ? 759 HOH   A O   1 
HETATM 5358 O  O   . HOH   I 5 .   ? -20.22179 2.48429   -44.69195 1.000 20.73452 ? 760 HOH   A O   1 
HETATM 5359 O  O   . HOH   I 5 .   ? -10.54463 3.56332   -46.07481 1.000 23.24929 ? 761 HOH   A O   1 
HETATM 5360 O  O   . HOH   I 5 .   ? -20.04391 0.53698   -26.05321 1.000 13.39312 ? 762 HOH   A O   1 
HETATM 5361 O  O   . HOH   I 5 .   ? -8.84756  8.59956   -5.93179  1.000 24.04708 ? 763 HOH   A O   1 
HETATM 5362 O  O   . HOH   I 5 .   ? -12.18420 5.42956   -18.27112 1.000 10.93768 ? 764 HOH   A O   1 
HETATM 5363 O  O   . HOH   I 5 .   ? -24.21990 1.05332   -33.96314 1.000 17.09508 ? 765 HOH   A O   1 
HETATM 5364 O  O   . HOH   I 5 .   ? -39.33886 0.40215   -22.79295 1.000 28.14877 ? 766 HOH   A O   1 
HETATM 5365 O  O   . HOH   I 5 .   ? 6.02086   -2.05694  -36.27987 1.000 25.62449 ? 767 HOH   A O   1 
HETATM 5366 O  O   . HOH   I 5 .   ? -3.28886  -11.28637 -22.02289 1.000 19.83631 ? 768 HOH   A O   1 
HETATM 5367 O  O   . HOH   I 5 .   ? -24.49454 17.51217  -31.45066 1.000 18.96084 ? 769 HOH   A O   1 
HETATM 5368 O  O   . HOH   I 5 .   ? -21.16470 16.85040  -23.79781 1.000 18.91842 ? 770 HOH   A O   1 
HETATM 5369 O  O   . HOH   I 5 .   ? -17.33545 -12.74981 -9.00085  1.000 26.74131 ? 771 HOH   A O   1 
HETATM 5370 O  O   . HOH   I 5 .   ? -26.49939 0.25401   -33.97000 1.000 18.98853 ? 772 HOH   A O   1 
HETATM 5371 O  O   . HOH   I 5 .   ? -23.16360 18.57555  -25.12153 1.000 23.42834 ? 773 HOH   A O   1 
HETATM 5372 O  O   . HOH   I 5 .   ? 2.19272   22.95828  -28.55806 1.000 28.53271 ? 774 HOH   A O   1 
HETATM 5373 O  O   . HOH   I 5 .   ? -21.82726 1.58307   -9.22862  1.000 19.84433 ? 775 HOH   A O   1 
HETATM 5374 O  O   . HOH   I 5 .   ? -22.48491 14.29363  -23.82376 1.000 18.42259 ? 776 HOH   A O   1 
HETATM 5375 O  O   . HOH   I 5 .   ? -19.45535 -17.32779 -14.22167 1.000 31.64652 ? 777 HOH   A O   1 
HETATM 5376 O  O   . HOH   I 5 .   ? 2.32821   5.61686   -39.76058 1.000 17.38487 ? 778 HOH   A O   1 
HETATM 5377 O  O   . HOH   I 5 .   ? -21.29196 -8.92129  -36.20197 1.000 17.48911 ? 779 HOH   A O   1 
HETATM 5378 O  O   . HOH   I 5 .   ? -28.21688 -5.50037  -19.49344 1.000 19.89916 ? 780 HOH   A O   1 
HETATM 5379 O  O   . HOH   I 5 .   ? -0.90694  19.96868  -36.10036 1.000 16.24210 ? 781 HOH   A O   1 
HETATM 5380 O  O   . HOH   I 5 .   ? -14.51793 -7.92306  -10.40093 1.000 22.14061 ? 782 HOH   A O   1 
HETATM 5381 O  O   . HOH   I 5 .   ? -20.72489 2.27688   -27.85545 1.000 6.99062  ? 783 HOH   A O   1 
HETATM 5382 O  O   . HOH   I 5 .   ? -3.55399  -4.33672  -25.05991 1.000 22.95988 ? 784 HOH   A O   1 
HETATM 5383 O  O   . HOH   I 5 .   ? -22.19051 4.07575   -32.99756 1.000 8.14968  ? 785 HOH   A O   1 
HETATM 5384 O  O   . HOH   I 5 .   ? 1.96936   3.34449   -26.65008 1.000 27.20405 ? 786 HOH   A O   1 
HETATM 5385 O  O   . HOH   I 5 .   ? -17.40438 -4.46251  -34.53881 1.000 10.96881 ? 787 HOH   A O   1 
HETATM 5386 O  O   . HOH   I 5 .   ? -28.12288 -5.66065  -11.82249 1.000 21.33453 ? 788 HOH   A O   1 
HETATM 5387 O  O   . HOH   I 5 .   ? -14.97053 2.74197   -17.25332 1.000 9.74487  ? 789 HOH   A O   1 
HETATM 5388 O  O   . HOH   I 5 .   ? 1.67871   -11.19001 -35.57541 1.000 32.01167 ? 790 HOH   A O   1 
HETATM 5389 O  O   . HOH   I 5 .   ? -0.91108  8.49693   -47.00909 1.000 30.06003 ? 791 HOH   A O   1 
HETATM 5390 O  O   . HOH   I 5 .   ? 3.09523   7.76150   -27.39162 1.000 17.80309 ? 792 HOH   A O   1 
HETATM 5391 O  O   . HOH   I 5 .   ? -4.30851  -7.20600  -17.45181 1.000 25.21520 ? 793 HOH   A O   1 
HETATM 5392 O  O   . HOH   I 5 .   ? -24.73243 2.41900   -31.41805 1.000 12.92814 ? 794 HOH   A O   1 
HETATM 5393 O  O   . HOH   I 5 .   ? -5.79889  -11.79901 -39.58846 1.000 23.39678 ? 795 HOH   A O   1 
HETATM 5394 O  O   . HOH   I 5 .   ? -18.58703 -1.65174  -23.17251 1.000 12.29354 ? 796 HOH   A O   1 
HETATM 5395 O  O   . HOH   I 5 .   ? -19.29964 -9.31130  -38.94715 1.000 23.64685 ? 797 HOH   A O   1 
HETATM 5396 O  O   . HOH   I 5 .   ? -3.49279  -5.07282  -22.61112 1.000 26.86773 ? 798 HOH   A O   1 
HETATM 5397 O  O   . HOH   I 5 .   ? -22.48927 9.74514   -13.17392 1.000 19.85298 ? 799 HOH   A O   1 
HETATM 5398 O  O   . HOH   I 5 .   ? -7.09744  25.48328  -36.99826 1.000 24.61402 ? 800 HOH   A O   1 
HETATM 5399 O  O   . HOH   I 5 .   ? -31.24267 1.72769   -15.73139 1.000 19.71485 ? 801 HOH   A O   1 
HETATM 5400 O  O   . HOH   I 5 .   ? -28.56707 -1.61240  -34.90700 1.000 15.11541 ? 802 HOH   A O   1 
HETATM 5401 O  O   . HOH   I 5 .   ? -26.41725 0.84267   -40.38115 1.000 9.93294  ? 803 HOH   A O   1 
HETATM 5402 O  O   . HOH   I 5 .   ? -30.84916 8.01364   -23.24778 1.000 26.03147 ? 804 HOH   A O   1 
HETATM 5403 O  O   . HOH   I 5 .   ? -13.70614 -0.51711  -41.35257 1.000 18.96200 ? 805 HOH   A O   1 
HETATM 5404 O  O   . HOH   I 5 .   ? -14.66927 -16.03017 -34.35837 1.000 32.70060 ? 806 HOH   A O   1 
HETATM 5405 O  O   . HOH   I 5 .   ? -27.95737 12.86043  -34.07273 1.000 20.73122 ? 807 HOH   A O   1 
HETATM 5406 O  O   . HOH   I 5 .   ? -34.66636 11.89263  -39.17108 1.000 26.20801 ? 808 HOH   A O   1 
HETATM 5407 O  O   . HOH   I 5 .   ? -22.13580 2.80862   -30.52996 1.000 9.69669  ? 809 HOH   A O   1 
HETATM 5408 O  O   . HOH   I 5 .   ? -7.33526  7.20564   -6.89321  1.000 33.91818 ? 810 HOH   A O   1 
HETATM 5409 O  O   . HOH   I 5 .   ? 4.57308   8.88084   -36.98336 1.000 20.70358 ? 811 HOH   A O   1 
HETATM 5410 O  O   . HOH   I 5 .   ? -20.62819 11.33632  -13.79179 1.000 23.96352 ? 812 HOH   A O   1 
HETATM 5411 O  O   . HOH   I 5 .   ? -3.80523  -0.87394  -15.52646 1.000 18.91295 ? 813 HOH   A O   1 
HETATM 5412 O  O   . HOH   I 5 .   ? 1.61271   2.20507   -29.05319 1.000 22.55093 ? 814 HOH   A O   1 
HETATM 5413 O  O   . HOH   I 5 .   ? 6.82890   7.24373   -34.92744 1.000 27.02081 ? 815 HOH   A O   1 
HETATM 5414 O  O   . HOH   I 5 .   ? -27.03578 -0.60324  -30.84226 1.000 30.22447 ? 816 HOH   A O   1 
HETATM 5415 O  O   . HOH   I 5 .   ? -1.65264  -4.37604  -46.50632 1.000 23.57551 ? 817 HOH   A O   1 
HETATM 5416 O  O   . HOH   I 5 .   ? -31.28529 7.18859   -21.47712 1.000 56.20844 ? 818 HOH   A O   1 
HETATM 5417 O  O   . HOH   I 5 .   ? -31.89392 10.95226  -38.50142 1.000 14.94974 ? 819 HOH   A O   1 
HETATM 5418 O  O   . HOH   I 5 .   ? -25.54755 -17.15575 -6.31650  1.000 31.58884 ? 820 HOH   A O   1 
HETATM 5419 O  O   . HOH   I 5 .   ? -31.29438 12.78895  -29.75085 1.000 31.88934 ? 821 HOH   A O   1 
HETATM 5420 O  O   . HOH   I 5 .   ? -28.43089 -6.22469  -9.75835  1.000 34.16375 ? 822 HOH   A O   1 
HETATM 5421 O  O   . HOH   I 5 .   ? -2.97338  -3.59182  -21.08080 1.000 26.41323 ? 823 HOH   A O   1 
HETATM 5422 O  O   . HOH   I 5 .   ? -29.34223 11.36598  -19.71531 1.000 30.06065 ? 824 HOH   A O   1 
HETATM 5423 O  O   . HOH   I 5 .   ? -10.35968 5.58329   -46.99694 1.000 21.90321 ? 825 HOH   A O   1 
HETATM 5424 O  O   . HOH   I 5 .   ? -5.70283  7.71605   -48.53139 1.000 29.52837 ? 826 HOH   A O   1 
HETATM 5425 O  O   . HOH   I 5 .   ? -26.83286 1.34213   -29.72862 1.000 23.10885 ? 827 HOH   A O   1 
HETATM 5426 O  O   . HOH   J 5 .   ? -23.28336 3.36261   -86.19957 1.000 27.96894 ? 701 HOH   B O   1 
HETATM 5427 O  O   . HOH   J 5 .   ? -37.38302 -9.09783  -68.20897 1.000 40.31197 ? 702 HOH   B O   1 
HETATM 5428 O  O   . HOH   J 5 .   ? -34.95502 -16.74596 -69.28910 1.000 47.70765 ? 703 HOH   B O   1 
HETATM 5429 O  O   . HOH   J 5 .   ? -33.93466 -10.63841 -54.31237 1.000 31.75862 ? 704 HOH   B O   1 
HETATM 5430 O  O   . HOH   J 5 .   ? -10.05912 11.66786  -61.13082 1.000 22.14913 ? 705 HOH   B O   1 
HETATM 5431 O  O   . HOH   J 5 .   ? -23.02149 5.62505   -60.24075 1.000 9.76643  ? 706 HOH   B O   1 
HETATM 5432 O  O   . HOH   J 5 .   ? -35.089   20.096    -65.792   1.000 27.20237 ? 707 HOH   B O   1 
HETATM 5433 O  O   . HOH   J 5 .   ? -9.59907  8.42825   -46.66719 1.000 12.25122 ? 708 HOH   B O   1 
HETATM 5434 O  O   . HOH   J 5 .   ? -20.12192 0.97353   -63.41207 1.000 13.36708 ? 709 HOH   B O   1 
HETATM 5435 O  O   . HOH   J 5 .   ? -33.43289 -2.85279  -47.02692 1.000 18.97862 ? 710 HOH   B O   1 
HETATM 5436 O  O   . HOH   J 5 .   ? -24.46119 2.91111   -73.95199 1.000 18.10891 ? 711 HOH   B O   1 
HETATM 5437 O  O   . HOH   J 5 .   ? -4.67026  -1.28692  -75.80240 1.000 20.59015 ? 712 HOH   B O   1 
HETATM 5438 O  O   . HOH   J 5 .   ? -23.27681 21.08057  -62.62665 1.000 18.90034 ? 713 HOH   B O   1 
HETATM 5439 O  O   . HOH   J 5 .   ? -16.75835 12.76428  -64.09848 1.000 20.10286 ? 714 HOH   B O   1 
HETATM 5440 O  O   . HOH   J 5 .   ? -25.90873 12.92607  -50.11516 1.000 9.59409  ? 715 HOH   B O   1 
HETATM 5441 O  O   . HOH   J 5 .   ? -29.41622 0.94513   -76.53427 1.000 31.37518 ? 716 HOH   B O   1 
HETATM 5442 O  O   . HOH   J 5 .   ? -20.20102 5.20881   -60.83914 1.000 12.93326 ? 717 HOH   B O   1 
HETATM 5443 O  O   . HOH   J 5 .   ? -11.34019 -5.51117  -66.58328 1.000 20.93356 ? 718 HOH   B O   1 
HETATM 5444 O  O   . HOH   J 5 .   ? -21.09287 -6.63548  -86.13636 1.000 23.88150 ? 719 HOH   B O   1 
HETATM 5445 O  O   . HOH   J 5 .   ? -17.43063 7.01278   -59.66301 1.000 20.48646 ? 720 HOH   B O   1 
HETATM 5446 O  O   . HOH   J 5 .   ? -22.03392 5.31120   -63.22554 1.000 12.33247 ? 721 HOH   B O   1 
HETATM 5447 O  O   . HOH   J 5 .   ? -47.85636 15.44701  -59.27240 1.000 31.70627 ? 722 HOH   B O   1 
HETATM 5448 O  O   . HOH   J 5 .   ? -30.19612 3.94284   -74.91340 1.000 20.61330 ? 723 HOH   B O   1 
HETATM 5449 O  O   . HOH   J 5 .   ? -14.28189 5.59085   -57.46561 1.000 19.11439 ? 724 HOH   B O   1 
HETATM 5450 O  O   . HOH   J 5 .   ? -14.78148 14.32760  -64.90527 1.000 19.45266 ? 725 HOH   B O   1 
HETATM 5451 O  O   . HOH   J 5 .   ? -24.43418 6.57249   -71.62192 1.000 14.79070 ? 726 HOH   B O   1 
HETATM 5452 O  O   . HOH   J 5 .   ? -38.14545 -2.21053  -79.68985 1.000 39.30674 ? 727 HOH   B O   1 
HETATM 5453 O  O   . HOH   J 5 .   ? -23.71665 -14.08150 -75.38175 1.000 27.12304 ? 728 HOH   B O   1 
HETATM 5454 O  O   . HOH   J 5 .   ? -23.21595 -9.45402  -85.14461 1.000 32.16085 ? 729 HOH   B O   1 
HETATM 5455 O  O   . HOH   J 5 .   ? -14.55747 4.82033   -54.28979 1.000 22.36901 ? 730 HOH   B O   1 
HETATM 5456 O  O   . HOH   J 5 .   ? -15.23914 12.37702  -43.43991 1.000 11.90503 ? 731 HOH   B O   1 
HETATM 5457 O  O   . HOH   J 5 .   ? -33.316   -22.563   -52.815   1.000 22.83031 ? 732 HOH   B O   1 
HETATM 5458 O  O   . HOH   J 5 .   ? -14.863   5.363     -90.918   1.000 14.23513 ? 733 HOH   B O   1 
HETATM 5459 O  O   . HOH   J 5 .   ? -25.67944 15.16827  -63.22138 1.000 13.71188 ? 734 HOH   B O   1 
HETATM 5460 O  O   . HOH   J 5 .   ? -49.16109 9.77073   -54.48645 1.000 29.72653 ? 735 HOH   B O   1 
HETATM 5461 O  O   . HOH   J 5 .   ? -20.29401 3.25463   -71.21683 1.000 13.42152 ? 736 HOH   B O   1 
HETATM 5462 O  O   . HOH   J 5 .   ? -29.86036 19.44056  -61.58055 1.000 28.13787 ? 737 HOH   B O   1 
HETATM 5463 O  O   . HOH   J 5 .   ? -20.52787 5.30217   -67.88611 1.000 18.66913 ? 738 HOH   B O   1 
HETATM 5464 O  O   . HOH   J 5 .   ? -21.02653 6.47217   -65.76428 1.000 10.13974 ? 739 HOH   B O   1 
HETATM 5465 O  O   . HOH   J 5 .   ? -21.06169 7.96267   -60.11272 1.000 8.90905  ? 740 HOH   B O   1 
HETATM 5466 O  O   . HOH   J 5 .   ? -17.75265 -1.38048  -60.86514 1.000 15.27152 ? 741 HOH   B O   1 
HETATM 5467 O  O   . HOH   J 5 .   ? -16.62408 18.20710  -65.62659 1.000 18.73753 ? 742 HOH   B O   1 
HETATM 5468 O  O   . HOH   J 5 .   ? -28.52754 11.51979  -82.05795 1.000 54.16750 ? 743 HOH   B O   1 
HETATM 5469 O  O   . HOH   J 5 .   ? -14.38757 10.11606  -80.87487 1.000 26.52596 ? 744 HOH   B O   1 
HETATM 5470 O  O   . HOH   J 5 .   ? -23.52820 -1.96501  -60.90526 1.000 24.93247 ? 745 HOH   B O   1 
HETATM 5471 O  O   . HOH   J 5 .   ? -46.48545 1.76496   -55.48412 1.000 26.15746 ? 746 HOH   B O   1 
HETATM 5472 O  O   . HOH   J 5 .   ? -12.36563 -4.02010  -57.27702 1.000 28.64021 ? 747 HOH   B O   1 
HETATM 5473 O  O   . HOH   J 5 .   ? -15.23023 8.52777   -59.73871 1.000 15.85340 ? 748 HOH   B O   1 
HETATM 5474 O  O   . HOH   J 5 .   ? -6.94693  12.93094  -79.07995 1.000 29.87007 ? 749 HOH   B O   1 
HETATM 5475 O  O   . HOH   J 5 .   ? -18.33359 8.96949   -61.86293 1.000 11.64124 ? 750 HOH   B O   1 
HETATM 5476 O  O   . HOH   J 5 .   ? -14.48389 2.46499   -46.23899 1.000 22.14322 ? 751 HOH   B O   1 
HETATM 5477 O  O   . HOH   J 5 .   ? -3.69064  1.47841   -86.02769 1.000 19.63770 ? 752 HOH   B O   1 
HETATM 5478 O  O   . HOH   J 5 .   ? -26.41949 4.58875   -76.25837 1.000 19.86560 ? 753 HOH   B O   1 
HETATM 5479 O  O   . HOH   J 5 .   ? -15.07259 7.38864   -53.20371 1.000 14.02742 ? 754 HOH   B O   1 
HETATM 5480 O  O   . HOH   J 5 .   ? -11.77482 -1.95296  -59.99836 1.000 24.36746 ? 755 HOH   B O   1 
HETATM 5481 O  O   . HOH   J 5 .   ? -32.62882 -19.35663 -61.89962 1.000 35.40751 ? 756 HOH   B O   1 
HETATM 5482 O  O   . HOH   J 5 .   ? -28.90255 17.19189  -70.70119 1.000 30.74334 ? 757 HOH   B O   1 
HETATM 5483 O  O   . HOH   J 5 .   ? -18.441   -8.274    -85.543   1.000 29.54126 ? 758 HOH   B O   1 
HETATM 5484 O  O   . HOH   J 5 .   ? -19.17635 18.55547  -68.57269 1.000 26.23409 ? 759 HOH   B O   1 
HETATM 5485 O  O   . HOH   J 5 .   ? -11.75151 13.97557  -48.35040 1.000 15.65708 ? 760 HOH   B O   1 
HETATM 5486 O  O   . HOH   J 5 .   ? -23.55681 17.51493  -57.10079 1.000 29.99168 ? 761 HOH   B O   1 
HETATM 5487 O  O   . HOH   J 5 .   ? -11.28159 8.74106   -74.85563 1.000 19.20839 ? 762 HOH   B O   1 
HETATM 5488 O  O   . HOH   J 5 .   ? -17.90901 20.81752  -51.59121 1.000 28.13772 ? 763 HOH   B O   1 
HETATM 5489 O  O   . HOH   J 5 .   ? -19.74829 7.20599   -86.88332 1.000 25.85954 ? 764 HOH   B O   1 
HETATM 5490 O  O   . HOH   J 5 .   ? -41.52054 -7.18888  -66.95709 1.000 34.36395 ? 765 HOH   B O   1 
HETATM 5491 O  O   . HOH   J 5 .   ? -7.66709  -1.51192  -86.84732 1.000 19.94389 ? 766 HOH   B O   1 
HETATM 5492 O  O   . HOH   J 5 .   ? -31.98522 18.67695  -66.06703 1.000 31.09693 ? 767 HOH   B O   1 
HETATM 5493 O  O   . HOH   J 5 .   ? -17.15765 -6.23701  -63.36385 1.000 30.27108 ? 768 HOH   B O   1 
HETATM 5494 O  O   . HOH   J 5 .   ? -10.78664 -5.65239  -77.10207 1.000 25.08310 ? 769 HOH   B O   1 
HETATM 5495 O  O   . HOH   J 5 .   ? -19.19261 18.22757  -52.55962 1.000 19.48576 ? 770 HOH   B O   1 
HETATM 5496 O  O   . HOH   J 5 .   ? -20.29511 7.40531   -62.91078 1.000 9.05056  ? 771 HOH   B O   1 
HETATM 5497 O  O   . HOH   J 5 .   ? -12.15137 8.50577   -59.01636 1.000 19.02858 ? 772 HOH   B O   1 
HETATM 5498 O  O   . HOH   J 5 .   ? -40.66392 14.68602  -68.36906 1.000 50.08369 ? 773 HOH   B O   1 
HETATM 5499 O  O   . HOH   J 5 .   ? -47.28588 -4.10787  -45.83420 1.000 36.17175 ? 774 HOH   B O   1 
HETATM 5500 O  O   . HOH   J 5 .   ? -9.53030  -4.60581  -83.31147 1.000 23.71243 ? 775 HOH   B O   1 
HETATM 5501 O  O   . HOH   J 5 .   ? -7.89333  -3.15836  -88.73256 1.000 26.69724 ? 776 HOH   B O   1 
HETATM 5502 O  O   . HOH   J 5 .   ? -5.25823  -0.19167  -87.09108 1.000 24.49311 ? 777 HOH   B O   1 
HETATM 5503 O  O   . HOH   J 5 .   ? -33.37635 -5.24283  -45.96734 1.000 31.94161 ? 778 HOH   B O   1 
HETATM 5504 O  O   . HOH   J 5 .   ? -12.30072 -6.05870  -79.30967 1.000 27.83468 ? 779 HOH   B O   1 
HETATM 5505 O  O   . HOH   J 5 .   ? -17.394   4.932     -91.063   1.000 28.04469 ? 780 HOH   B O   1 
HETATM 5506 O  O   . HOH   J 5 .   ? -11.87879 6.33939   -55.94931 1.000 30.81627 ? 781 HOH   B O   1 
HETATM 5507 O  O   . HOH   J 5 .   ? -28.71147 -2.69624  -46.83346 1.000 15.32090 ? 782 HOH   B O   1 
# 
