data_8ZPN
# 
_entry.id   8ZPN 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZPN         pdb_00008zpn 10.2210/pdb8zpn/pdb 
WWPDB D_1300048278 ?            ?                   
EMDB  EMD-60350    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-26 ? 
2 'EM metadata'     1 0 2025-02-26 ? 
3 'Additional map'  1 0 2025-02-26 1 
4 FSC               1 0 2025-02-26 ? 
5 'Half map'        1 0 2025-02-26 1 
6 'Half map'        1 0 2025-02-26 2 
7 Image             1 0 2025-02-26 ? 
8 'Primary map'     1 0 2025-02-26 ? 
9 'Structure model' 1 1 2025-04-02 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Additional map'  repository 'Initial release' ? ? 
4 4 FSC               repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 'Half map'        repository 'Initial release' ? ? 
7 7 Image             repository 'Initial release' ? ? 
8 8 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 9 'Structure model' 'Data collection'     
2 9 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 9 'Structure model' citation        
2 9 'Structure model' citation_author 
3 9 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  9 'Structure model' '_citation.country'                 
2  9 'Structure model' '_citation.journal_abbrev'          
3  9 'Structure model' '_citation.journal_id_ASTM'         
4  9 'Structure model' '_citation.journal_id_CSD'          
5  9 'Structure model' '_citation.journal_id_ISSN'         
6  9 'Structure model' '_citation.journal_volume'          
7  9 'Structure model' '_citation.page_first'              
8  9 'Structure model' '_citation.page_last'               
9  9 'Structure model' '_citation.pdbx_database_id_DOI'    
10 9 'Structure model' '_citation.pdbx_database_id_PubMed' 
11 9 'Structure model' '_citation.title'                   
12 9 'Structure model' '_citation.year'                    
13 9 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZPN 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-30 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM strucutre of CXCR4 complexed with antagonist AMD3100' 
_pdbx_database_related.db_id          EMD-60350 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              honglihu@cuhk.edu.cn 
_pdbx_contact_author.name_first         Hongli 
_pdbx_contact_author.name_last          Hu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3658-272X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Jiao, H.Z.' 1 ? 
'Hu, H.L.'   2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Proc.Natl.Acad.Sci.USA 
_citation.journal_id_ASTM           PNASA6 
_citation.journal_id_CSD            0040 
_citation.journal_id_ISSN           1091-6490 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            122 
_citation.language                  ? 
_citation.page_first                e2425795122 
_citation.page_last                 e2425795122 
_citation.title                     
'Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1073/pnas.2425795122 
_citation.pdbx_database_id_PubMed   40063796 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sang, X.'  1  0009-0002-6561-2254 
primary 'Jiao, H.'  2  ?                   
primary 'Meng, Q.'  3  ?                   
primary 'Fang, X.'  4  ?                   
primary 'Pan, Q.'   5  ?                   
primary 'Zhou, J.'  6  ?                   
primary 'Qian, T.'  7  ?                   
primary 'Zhang, W.' 8  ?                   
primary 'Xu, Y.'    9  ?                   
primary 'An, J.'    10 ?                   
primary 'Huang, Z.' 11 ?                   
primary 'Hu, H.'    12 0000-0003-3658-272X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Soluble cytochrome b562,C-X-C chemokine receptor type 4' 55451.062 1 ? ? ? ? 
2 polymer     man 'Nb6 nanobody'                                            18665.906 1 ? ? ? ? 
3 non-polymer syn CHOLESTEROL                                               386.654   1 ? ? ? ? 
4 non-polymer syn Plerixafor                                                502.782   1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;Cytochrome b-562,CXC-R4,CXCR-4,FB22,Fusin,HM89,LCR1,Leukocyte-derived seven transmembrane domain receptor,LESTR,Lipopolysaccharide-associated protein 3,LAP-3,LPS-associated protein 3,NPYRL,Stromal cell-derived factor 1 receptor,SDF-1 receptor
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MKTIIALSYIFCLVFADYKDDDDKGSADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPD
SPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLLVPRGSMEGISIYTSDNYTEEMGSGDYD
SMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANW
YFGNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD
RYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISRLKSVRLLSGSREKDRNLRRITRPTVILILAFFACWLP
YYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSGRPLEVLFQGPHHHH
HHHHHH
;
;MKTIIALSYIFCLVFADYKDDDDKGSADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPD
SPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLLVPRGSMEGISIYTSDNYTEEMGSGDYD
SMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANW
YFGNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD
RYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISRLKSVRLLSGSREKDRNLRRITRPTVILILAFFACWLP
YYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSGRPLEVLFQGPHHHH
HHHHHH
;
R ? 
2 'polypeptide(L)' no no 
;MLLVNQSHQGFNKEHTSKMVSAIVLYVLLAAAAHSAFAMAQVQLQESGGGLVQAGESLRLSCAASGTIFRLYDMGWYRRV
SGNQRELVASITSGGSTKYGDSVKGRFTISRDNAKNTVYLQMSSLKPEDTAVYYCNAEYRTGIWEELLDGWGQGTQVTVS
SHHHHHHHH
;
;MLLVNQSHQGFNKEHTSKMVSAIVLYVLLAAAAHSAFAMAQVQLQESGGGLVQAGESLRLSCAASGTIFRLYDMGWYRRV
SGNQRELVASITSGGSTKYGDSVKGRFTISRDNAKNTVYLQMSSLKPEDTAVYYCNAEYRTGIWEELLDGWGQGTQVTVS
SHHHHHHHH
;
N ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 CHOLESTEROL CLR 
4 Plerixafor  VH6 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LYS n 
1 3   THR n 
1 4   ILE n 
1 5   ILE n 
1 6   ALA n 
1 7   LEU n 
1 8   SER n 
1 9   TYR n 
1 10  ILE n 
1 11  PHE n 
1 12  CYS n 
1 13  LEU n 
1 14  VAL n 
1 15  PHE n 
1 16  ALA n 
1 17  ASP n 
1 18  TYR n 
1 19  LYS n 
1 20  ASP n 
1 21  ASP n 
1 22  ASP n 
1 23  ASP n 
1 24  LYS n 
1 25  GLY n 
1 26  SER n 
1 27  ALA n 
1 28  ASP n 
1 29  LEU n 
1 30  GLU n 
1 31  ASP n 
1 32  ASN n 
1 33  TRP n 
1 34  GLU n 
1 35  THR n 
1 36  LEU n 
1 37  ASN n 
1 38  ASP n 
1 39  ASN n 
1 40  LEU n 
1 41  LYS n 
1 42  VAL n 
1 43  ILE n 
1 44  GLU n 
1 45  LYS n 
1 46  ALA n 
1 47  ASP n 
1 48  ASN n 
1 49  ALA n 
1 50  ALA n 
1 51  GLN n 
1 52  VAL n 
1 53  LYS n 
1 54  ASP n 
1 55  ALA n 
1 56  LEU n 
1 57  THR n 
1 58  LYS n 
1 59  MET n 
1 60  ARG n 
1 61  ALA n 
1 62  ALA n 
1 63  ALA n 
1 64  LEU n 
1 65  ASP n 
1 66  ALA n 
1 67  GLN n 
1 68  LYS n 
1 69  ALA n 
1 70  THR n 
1 71  PRO n 
1 72  PRO n 
1 73  LYS n 
1 74  LEU n 
1 75  GLU n 
1 76  ASP n 
1 77  LYS n 
1 78  SER n 
1 79  PRO n 
1 80  ASP n 
1 81  SER n 
1 82  PRO n 
1 83  GLU n 
1 84  MET n 
1 85  LYS n 
1 86  ASP n 
1 87  PHE n 
1 88  ARG n 
1 89  HIS n 
1 90  GLY n 
1 91  PHE n 
1 92  ASP n 
1 93  ILE n 
1 94  LEU n 
1 95  VAL n 
1 96  GLY n 
1 97  GLN n 
1 98  ILE n 
1 99  ASP n 
1 100 ASP n 
1 101 ALA n 
1 102 LEU n 
1 103 LYS n 
1 104 LEU n 
1 105 ALA n 
1 106 ASN n 
1 107 GLU n 
1 108 GLY n 
1 109 LYS n 
1 110 VAL n 
1 111 LYS n 
1 112 GLU n 
1 113 ALA n 
1 114 GLN n 
1 115 ALA n 
1 116 ALA n 
1 117 ALA n 
1 118 GLU n 
1 119 GLN n 
1 120 LEU n 
1 121 LYS n 
1 122 THR n 
1 123 THR n 
1 124 ARG n 
1 125 ASN n 
1 126 ALA n 
1 127 TYR n 
1 128 ILE n 
1 129 GLN n 
1 130 LYS n 
1 131 TYR n 
1 132 LEU n 
1 133 LEU n 
1 134 VAL n 
1 135 PRO n 
1 136 ARG n 
1 137 GLY n 
1 138 SER n 
1 139 MET n 
1 140 GLU n 
1 141 GLY n 
1 142 ILE n 
1 143 SER n 
1 144 ILE n 
1 145 TYR n 
1 146 THR n 
1 147 SER n 
1 148 ASP n 
1 149 ASN n 
1 150 TYR n 
1 151 THR n 
1 152 GLU n 
1 153 GLU n 
1 154 MET n 
1 155 GLY n 
1 156 SER n 
1 157 GLY n 
1 158 ASP n 
1 159 TYR n 
1 160 ASP n 
1 161 SER n 
1 162 MET n 
1 163 LYS n 
1 164 GLU n 
1 165 PRO n 
1 166 CYS n 
1 167 PHE n 
1 168 ARG n 
1 169 GLU n 
1 170 GLU n 
1 171 ASN n 
1 172 ALA n 
1 173 ASN n 
1 174 PHE n 
1 175 ASN n 
1 176 LYS n 
1 177 ILE n 
1 178 PHE n 
1 179 LEU n 
1 180 PRO n 
1 181 THR n 
1 182 ILE n 
1 183 TYR n 
1 184 SER n 
1 185 ILE n 
1 186 ILE n 
1 187 PHE n 
1 188 LEU n 
1 189 THR n 
1 190 GLY n 
1 191 ILE n 
1 192 VAL n 
1 193 GLY n 
1 194 ASN n 
1 195 GLY n 
1 196 LEU n 
1 197 VAL n 
1 198 ILE n 
1 199 LEU n 
1 200 VAL n 
1 201 MET n 
1 202 GLY n 
1 203 TYR n 
1 204 GLN n 
1 205 LYS n 
1 206 LYS n 
1 207 LEU n 
1 208 ARG n 
1 209 SER n 
1 210 MET n 
1 211 THR n 
1 212 ASP n 
1 213 LYS n 
1 214 TYR n 
1 215 ARG n 
1 216 LEU n 
1 217 HIS n 
1 218 LEU n 
1 219 SER n 
1 220 VAL n 
1 221 ALA n 
1 222 ASP n 
1 223 LEU n 
1 224 LEU n 
1 225 PHE n 
1 226 VAL n 
1 227 ILE n 
1 228 THR n 
1 229 LEU n 
1 230 PRO n 
1 231 PHE n 
1 232 TRP n 
1 233 ALA n 
1 234 VAL n 
1 235 ASP n 
1 236 ALA n 
1 237 VAL n 
1 238 ALA n 
1 239 ASN n 
1 240 TRP n 
1 241 TYR n 
1 242 PHE n 
1 243 GLY n 
1 244 ASN n 
1 245 PHE n 
1 246 LEU n 
1 247 CYS n 
1 248 LYS n 
1 249 ALA n 
1 250 VAL n 
1 251 HIS n 
1 252 VAL n 
1 253 ILE n 
1 254 TYR n 
1 255 THR n 
1 256 VAL n 
1 257 ASN n 
1 258 LEU n 
1 259 TYR n 
1 260 SER n 
1 261 SER n 
1 262 VAL n 
1 263 TRP n 
1 264 ILE n 
1 265 LEU n 
1 266 ALA n 
1 267 PHE n 
1 268 ILE n 
1 269 SER n 
1 270 LEU n 
1 271 ASP n 
1 272 ARG n 
1 273 TYR n 
1 274 LEU n 
1 275 ALA n 
1 276 ILE n 
1 277 VAL n 
1 278 HIS n 
1 279 ALA n 
1 280 THR n 
1 281 ASN n 
1 282 SER n 
1 283 GLN n 
1 284 ARG n 
1 285 PRO n 
1 286 ARG n 
1 287 LYS n 
1 288 LEU n 
1 289 LEU n 
1 290 ALA n 
1 291 GLU n 
1 292 LYS n 
1 293 VAL n 
1 294 VAL n 
1 295 TYR n 
1 296 VAL n 
1 297 GLY n 
1 298 VAL n 
1 299 TRP n 
1 300 ILE n 
1 301 PRO n 
1 302 ALA n 
1 303 LEU n 
1 304 LEU n 
1 305 LEU n 
1 306 THR n 
1 307 ILE n 
1 308 PRO n 
1 309 ASP n 
1 310 PHE n 
1 311 ILE n 
1 312 PHE n 
1 313 ALA n 
1 314 ASN n 
1 315 VAL n 
1 316 SER n 
1 317 GLU n 
1 318 ALA n 
1 319 ASP n 
1 320 ASP n 
1 321 ARG n 
1 322 TYR n 
1 323 ILE n 
1 324 CYS n 
1 325 ASP n 
1 326 ARG n 
1 327 PHE n 
1 328 TYR n 
1 329 PRO n 
1 330 ASN n 
1 331 ASP n 
1 332 LEU n 
1 333 TRP n 
1 334 VAL n 
1 335 VAL n 
1 336 VAL n 
1 337 PHE n 
1 338 GLN n 
1 339 PHE n 
1 340 GLN n 
1 341 HIS n 
1 342 ILE n 
1 343 MET n 
1 344 VAL n 
1 345 GLY n 
1 346 LEU n 
1 347 ILE n 
1 348 LEU n 
1 349 PRO n 
1 350 GLY n 
1 351 ILE n 
1 352 VAL n 
1 353 ILE n 
1 354 LEU n 
1 355 SER n 
1 356 CYS n 
1 357 TYR n 
1 358 CYS n 
1 359 ILE n 
1 360 ILE n 
1 361 ILE n 
1 362 SER n 
1 363 ARG n 
1 364 LEU n 
1 365 LYS n 
1 366 SER n 
1 367 VAL n 
1 368 ARG n 
1 369 LEU n 
1 370 LEU n 
1 371 SER n 
1 372 GLY n 
1 373 SER n 
1 374 ARG n 
1 375 GLU n 
1 376 LYS n 
1 377 ASP n 
1 378 ARG n 
1 379 ASN n 
1 380 LEU n 
1 381 ARG n 
1 382 ARG n 
1 383 ILE n 
1 384 THR n 
1 385 ARG n 
1 386 PRO n 
1 387 THR n 
1 388 VAL n 
1 389 ILE n 
1 390 LEU n 
1 391 ILE n 
1 392 LEU n 
1 393 ALA n 
1 394 PHE n 
1 395 PHE n 
1 396 ALA n 
1 397 CYS n 
1 398 TRP n 
1 399 LEU n 
1 400 PRO n 
1 401 TYR n 
1 402 TYR n 
1 403 ILE n 
1 404 GLY n 
1 405 ILE n 
1 406 SER n 
1 407 ILE n 
1 408 ASP n 
1 409 SER n 
1 410 PHE n 
1 411 ILE n 
1 412 LEU n 
1 413 LEU n 
1 414 GLU n 
1 415 ILE n 
1 416 ILE n 
1 417 LYS n 
1 418 GLN n 
1 419 GLY n 
1 420 CYS n 
1 421 GLU n 
1 422 PHE n 
1 423 GLU n 
1 424 ASN n 
1 425 THR n 
1 426 VAL n 
1 427 HIS n 
1 428 LYS n 
1 429 TRP n 
1 430 ILE n 
1 431 SER n 
1 432 ILE n 
1 433 THR n 
1 434 GLU n 
1 435 ALA n 
1 436 LEU n 
1 437 ALA n 
1 438 PHE n 
1 439 PHE n 
1 440 HIS n 
1 441 CYS n 
1 442 CYS n 
1 443 LEU n 
1 444 ASN n 
1 445 PRO n 
1 446 ILE n 
1 447 LEU n 
1 448 TYR n 
1 449 ALA n 
1 450 PHE n 
1 451 LEU n 
1 452 GLY n 
1 453 ALA n 
1 454 LYS n 
1 455 PHE n 
1 456 LYS n 
1 457 THR n 
1 458 SER n 
1 459 ALA n 
1 460 GLN n 
1 461 HIS n 
1 462 ALA n 
1 463 LEU n 
1 464 THR n 
1 465 SER n 
1 466 GLY n 
1 467 ARG n 
1 468 PRO n 
1 469 LEU n 
1 470 GLU n 
1 471 VAL n 
1 472 LEU n 
1 473 PHE n 
1 474 GLN n 
1 475 GLY n 
1 476 PRO n 
1 477 HIS n 
1 478 HIS n 
1 479 HIS n 
1 480 HIS n 
1 481 HIS n 
1 482 HIS n 
1 483 HIS n 
1 484 HIS n 
1 485 HIS n 
1 486 HIS n 
2 1   MET n 
2 2   LEU n 
2 3   LEU n 
2 4   VAL n 
2 5   ASN n 
2 6   GLN n 
2 7   SER n 
2 8   HIS n 
2 9   GLN n 
2 10  GLY n 
2 11  PHE n 
2 12  ASN n 
2 13  LYS n 
2 14  GLU n 
2 15  HIS n 
2 16  THR n 
2 17  SER n 
2 18  LYS n 
2 19  MET n 
2 20  VAL n 
2 21  SER n 
2 22  ALA n 
2 23  ILE n 
2 24  VAL n 
2 25  LEU n 
2 26  TYR n 
2 27  VAL n 
2 28  LEU n 
2 29  LEU n 
2 30  ALA n 
2 31  ALA n 
2 32  ALA n 
2 33  ALA n 
2 34  HIS n 
2 35  SER n 
2 36  ALA n 
2 37  PHE n 
2 38  ALA n 
2 39  MET n 
2 40  ALA n 
2 41  GLN n 
2 42  VAL n 
2 43  GLN n 
2 44  LEU n 
2 45  GLN n 
2 46  GLU n 
2 47  SER n 
2 48  GLY n 
2 49  GLY n 
2 50  GLY n 
2 51  LEU n 
2 52  VAL n 
2 53  GLN n 
2 54  ALA n 
2 55  GLY n 
2 56  GLU n 
2 57  SER n 
2 58  LEU n 
2 59  ARG n 
2 60  LEU n 
2 61  SER n 
2 62  CYS n 
2 63  ALA n 
2 64  ALA n 
2 65  SER n 
2 66  GLY n 
2 67  THR n 
2 68  ILE n 
2 69  PHE n 
2 70  ARG n 
2 71  LEU n 
2 72  TYR n 
2 73  ASP n 
2 74  MET n 
2 75  GLY n 
2 76  TRP n 
2 77  TYR n 
2 78  ARG n 
2 79  ARG n 
2 80  VAL n 
2 81  SER n 
2 82  GLY n 
2 83  ASN n 
2 84  GLN n 
2 85  ARG n 
2 86  GLU n 
2 87  LEU n 
2 88  VAL n 
2 89  ALA n 
2 90  SER n 
2 91  ILE n 
2 92  THR n 
2 93  SER n 
2 94  GLY n 
2 95  GLY n 
2 96  SER n 
2 97  THR n 
2 98  LYS n 
2 99  TYR n 
2 100 GLY n 
2 101 ASP n 
2 102 SER n 
2 103 VAL n 
2 104 LYS n 
2 105 GLY n 
2 106 ARG n 
2 107 PHE n 
2 108 THR n 
2 109 ILE n 
2 110 SER n 
2 111 ARG n 
2 112 ASP n 
2 113 ASN n 
2 114 ALA n 
2 115 LYS n 
2 116 ASN n 
2 117 THR n 
2 118 VAL n 
2 119 TYR n 
2 120 LEU n 
2 121 GLN n 
2 122 MET n 
2 123 SER n 
2 124 SER n 
2 125 LEU n 
2 126 LYS n 
2 127 PRO n 
2 128 GLU n 
2 129 ASP n 
2 130 THR n 
2 131 ALA n 
2 132 VAL n 
2 133 TYR n 
2 134 TYR n 
2 135 CYS n 
2 136 ASN n 
2 137 ALA n 
2 138 GLU n 
2 139 TYR n 
2 140 ARG n 
2 141 THR n 
2 142 GLY n 
2 143 ILE n 
2 144 TRP n 
2 145 GLU n 
2 146 GLU n 
2 147 LEU n 
2 148 LEU n 
2 149 ASP n 
2 150 GLY n 
2 151 TRP n 
2 152 GLY n 
2 153 GLN n 
2 154 GLY n 
2 155 THR n 
2 156 GLN n 
2 157 VAL n 
2 158 THR n 
2 159 VAL n 
2 160 SER n 
2 161 SER n 
2 162 HIS n 
2 163 HIS n 
2 164 HIS n 
2 165 HIS n 
2 166 HIS n 
2 167 HIS n 
2 168 HIS n 
2 169 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   138 ?     ? cybC  ? ? ? ? ? ? 'Escherichia coli' 562  ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 
7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 2 sample 'Biological sequence' 139 386 human ? CXCR4 ? ? ? ? ? ? 'Homo sapiens'     9606 ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 
7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 3 sample 'Biological sequence' 387 486 human ? CXCR4 ? ? ? ? ? ? 'Homo sapiens'     9606 ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 
7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1   169 ?     ? ?     ? ? ? ? ? ? 'Lama glama'       9844 ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 
7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                                                                                   
'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                                                                                   
'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                                                                                   
'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                                                                                   
'C4 H7 N O4'     133.103 
CLR non-polymer         . CHOLESTEROL     ?                                                                                   
'C27 H46 O'      386.654 
CYS 'L-peptide linking' y CYSTEINE        ?                                                                                   
'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ?                                                                                   
'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                                                                                   
'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                                                                                   
'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ?                                                                                   
'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ?                                                                                   
'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                                                                                   
'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                                                                                   
'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                                                                                   
'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ?                                                                                   
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                                                                                   
'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                                                                                   
'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                                                                                   
'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                                                                                   
'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                                                                                   
'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                                                                                   
'C5 H11 N O2'    117.146 
VH6 non-polymer         . Plerixafor      
;1,1'-[1,4-phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane); AMD3100
;
'C28 H54 N8'     502.782 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -137 ?   ?   ?   R . n 
A 1 2   LYS 2   -136 ?   ?   ?   R . n 
A 1 3   THR 3   -135 ?   ?   ?   R . n 
A 1 4   ILE 4   -134 ?   ?   ?   R . n 
A 1 5   ILE 5   -133 ?   ?   ?   R . n 
A 1 6   ALA 6   -132 ?   ?   ?   R . n 
A 1 7   LEU 7   -131 ?   ?   ?   R . n 
A 1 8   SER 8   -130 ?   ?   ?   R . n 
A 1 9   TYR 9   -129 ?   ?   ?   R . n 
A 1 10  ILE 10  -128 ?   ?   ?   R . n 
A 1 11  PHE 11  -127 ?   ?   ?   R . n 
A 1 12  CYS 12  -126 ?   ?   ?   R . n 
A 1 13  LEU 13  -125 ?   ?   ?   R . n 
A 1 14  VAL 14  -124 ?   ?   ?   R . n 
A 1 15  PHE 15  -123 ?   ?   ?   R . n 
A 1 16  ALA 16  -122 ?   ?   ?   R . n 
A 1 17  ASP 17  -121 ?   ?   ?   R . n 
A 1 18  TYR 18  -120 ?   ?   ?   R . n 
A 1 19  LYS 19  -119 ?   ?   ?   R . n 
A 1 20  ASP 20  -118 ?   ?   ?   R . n 
A 1 21  ASP 21  -117 ?   ?   ?   R . n 
A 1 22  ASP 22  -116 ?   ?   ?   R . n 
A 1 23  ASP 23  -115 ?   ?   ?   R . n 
A 1 24  LYS 24  -114 ?   ?   ?   R . n 
A 1 25  GLY 25  -113 ?   ?   ?   R . n 
A 1 26  SER 26  -112 ?   ?   ?   R . n 
A 1 27  ALA 27  -111 ?   ?   ?   R . n 
A 1 28  ASP 28  -110 ?   ?   ?   R . n 
A 1 29  LEU 29  -109 ?   ?   ?   R . n 
A 1 30  GLU 30  -108 ?   ?   ?   R . n 
A 1 31  ASP 31  -107 ?   ?   ?   R . n 
A 1 32  ASN 32  -106 ?   ?   ?   R . n 
A 1 33  TRP 33  -105 ?   ?   ?   R . n 
A 1 34  GLU 34  -104 ?   ?   ?   R . n 
A 1 35  THR 35  -103 ?   ?   ?   R . n 
A 1 36  LEU 36  -102 ?   ?   ?   R . n 
A 1 37  ASN 37  -101 ?   ?   ?   R . n 
A 1 38  ASP 38  -100 ?   ?   ?   R . n 
A 1 39  ASN 39  -99  ?   ?   ?   R . n 
A 1 40  LEU 40  -98  ?   ?   ?   R . n 
A 1 41  LYS 41  -97  ?   ?   ?   R . n 
A 1 42  VAL 42  -96  ?   ?   ?   R . n 
A 1 43  ILE 43  -95  ?   ?   ?   R . n 
A 1 44  GLU 44  -94  ?   ?   ?   R . n 
A 1 45  LYS 45  -93  ?   ?   ?   R . n 
A 1 46  ALA 46  -92  ?   ?   ?   R . n 
A 1 47  ASP 47  -91  ?   ?   ?   R . n 
A 1 48  ASN 48  -90  ?   ?   ?   R . n 
A 1 49  ALA 49  -89  ?   ?   ?   R . n 
A 1 50  ALA 50  -88  ?   ?   ?   R . n 
A 1 51  GLN 51  -87  ?   ?   ?   R . n 
A 1 52  VAL 52  -86  ?   ?   ?   R . n 
A 1 53  LYS 53  -85  ?   ?   ?   R . n 
A 1 54  ASP 54  -84  ?   ?   ?   R . n 
A 1 55  ALA 55  -83  ?   ?   ?   R . n 
A 1 56  LEU 56  -82  ?   ?   ?   R . n 
A 1 57  THR 57  -81  ?   ?   ?   R . n 
A 1 58  LYS 58  -80  ?   ?   ?   R . n 
A 1 59  MET 59  -79  ?   ?   ?   R . n 
A 1 60  ARG 60  -78  ?   ?   ?   R . n 
A 1 61  ALA 61  -77  ?   ?   ?   R . n 
A 1 62  ALA 62  -76  ?   ?   ?   R . n 
A 1 63  ALA 63  -75  ?   ?   ?   R . n 
A 1 64  LEU 64  -74  ?   ?   ?   R . n 
A 1 65  ASP 65  -73  ?   ?   ?   R . n 
A 1 66  ALA 66  -72  ?   ?   ?   R . n 
A 1 67  GLN 67  -71  ?   ?   ?   R . n 
A 1 68  LYS 68  -70  ?   ?   ?   R . n 
A 1 69  ALA 69  -69  ?   ?   ?   R . n 
A 1 70  THR 70  -68  ?   ?   ?   R . n 
A 1 71  PRO 71  -67  ?   ?   ?   R . n 
A 1 72  PRO 72  -66  ?   ?   ?   R . n 
A 1 73  LYS 73  -65  ?   ?   ?   R . n 
A 1 74  LEU 74  -64  ?   ?   ?   R . n 
A 1 75  GLU 75  -63  ?   ?   ?   R . n 
A 1 76  ASP 76  -62  ?   ?   ?   R . n 
A 1 77  LYS 77  -61  ?   ?   ?   R . n 
A 1 78  SER 78  -60  ?   ?   ?   R . n 
A 1 79  PRO 79  -59  ?   ?   ?   R . n 
A 1 80  ASP 80  -58  ?   ?   ?   R . n 
A 1 81  SER 81  -57  ?   ?   ?   R . n 
A 1 82  PRO 82  -56  ?   ?   ?   R . n 
A 1 83  GLU 83  -55  ?   ?   ?   R . n 
A 1 84  MET 84  -54  ?   ?   ?   R . n 
A 1 85  LYS 85  -53  ?   ?   ?   R . n 
A 1 86  ASP 86  -52  ?   ?   ?   R . n 
A 1 87  PHE 87  -51  ?   ?   ?   R . n 
A 1 88  ARG 88  -50  ?   ?   ?   R . n 
A 1 89  HIS 89  -49  ?   ?   ?   R . n 
A 1 90  GLY 90  -48  ?   ?   ?   R . n 
A 1 91  PHE 91  -47  ?   ?   ?   R . n 
A 1 92  ASP 92  -46  ?   ?   ?   R . n 
A 1 93  ILE 93  -45  ?   ?   ?   R . n 
A 1 94  LEU 94  -44  ?   ?   ?   R . n 
A 1 95  VAL 95  -43  ?   ?   ?   R . n 
A 1 96  GLY 96  -42  ?   ?   ?   R . n 
A 1 97  GLN 97  -41  ?   ?   ?   R . n 
A 1 98  ILE 98  -40  ?   ?   ?   R . n 
A 1 99  ASP 99  -39  ?   ?   ?   R . n 
A 1 100 ASP 100 -38  ?   ?   ?   R . n 
A 1 101 ALA 101 -37  ?   ?   ?   R . n 
A 1 102 LEU 102 -36  ?   ?   ?   R . n 
A 1 103 LYS 103 -35  ?   ?   ?   R . n 
A 1 104 LEU 104 -34  ?   ?   ?   R . n 
A 1 105 ALA 105 -33  ?   ?   ?   R . n 
A 1 106 ASN 106 -32  ?   ?   ?   R . n 
A 1 107 GLU 107 -31  ?   ?   ?   R . n 
A 1 108 GLY 108 -30  ?   ?   ?   R . n 
A 1 109 LYS 109 -29  ?   ?   ?   R . n 
A 1 110 VAL 110 -28  ?   ?   ?   R . n 
A 1 111 LYS 111 -27  ?   ?   ?   R . n 
A 1 112 GLU 112 -26  ?   ?   ?   R . n 
A 1 113 ALA 113 -25  ?   ?   ?   R . n 
A 1 114 GLN 114 -24  ?   ?   ?   R . n 
A 1 115 ALA 115 -23  ?   ?   ?   R . n 
A 1 116 ALA 116 -22  ?   ?   ?   R . n 
A 1 117 ALA 117 -21  ?   ?   ?   R . n 
A 1 118 GLU 118 -20  ?   ?   ?   R . n 
A 1 119 GLN 119 -19  ?   ?   ?   R . n 
A 1 120 LEU 120 -18  ?   ?   ?   R . n 
A 1 121 LYS 121 -17  ?   ?   ?   R . n 
A 1 122 THR 122 -16  ?   ?   ?   R . n 
A 1 123 THR 123 -15  ?   ?   ?   R . n 
A 1 124 ARG 124 -14  ?   ?   ?   R . n 
A 1 125 ASN 125 -13  ?   ?   ?   R . n 
A 1 126 ALA 126 -12  ?   ?   ?   R . n 
A 1 127 TYR 127 -11  ?   ?   ?   R . n 
A 1 128 ILE 128 -10  ?   ?   ?   R . n 
A 1 129 GLN 129 -9   ?   ?   ?   R . n 
A 1 130 LYS 130 -8   ?   ?   ?   R . n 
A 1 131 TYR 131 -7   ?   ?   ?   R . n 
A 1 132 LEU 132 -6   ?   ?   ?   R . n 
A 1 133 LEU 133 -5   ?   ?   ?   R . n 
A 1 134 VAL 134 -4   ?   ?   ?   R . n 
A 1 135 PRO 135 -3   ?   ?   ?   R . n 
A 1 136 ARG 136 -2   ?   ?   ?   R . n 
A 1 137 GLY 137 -1   ?   ?   ?   R . n 
A 1 138 SER 138 0    ?   ?   ?   R . n 
A 1 139 MET 139 1    ?   ?   ?   R . n 
A 1 140 GLU 140 2    ?   ?   ?   R . n 
A 1 141 GLY 141 3    ?   ?   ?   R . n 
A 1 142 ILE 142 4    ?   ?   ?   R . n 
A 1 143 SER 143 5    ?   ?   ?   R . n 
A 1 144 ILE 144 6    ?   ?   ?   R . n 
A 1 145 TYR 145 7    ?   ?   ?   R . n 
A 1 146 THR 146 8    ?   ?   ?   R . n 
A 1 147 SER 147 9    ?   ?   ?   R . n 
A 1 148 ASP 148 10   ?   ?   ?   R . n 
A 1 149 ASN 149 11   ?   ?   ?   R . n 
A 1 150 TYR 150 12   ?   ?   ?   R . n 
A 1 151 THR 151 13   ?   ?   ?   R . n 
A 1 152 GLU 152 14   ?   ?   ?   R . n 
A 1 153 GLU 153 15   ?   ?   ?   R . n 
A 1 154 MET 154 16   ?   ?   ?   R . n 
A 1 155 GLY 155 17   ?   ?   ?   R . n 
A 1 156 SER 156 18   ?   ?   ?   R . n 
A 1 157 GLY 157 19   ?   ?   ?   R . n 
A 1 158 ASP 158 20   ?   ?   ?   R . n 
A 1 159 TYR 159 21   ?   ?   ?   R . n 
A 1 160 ASP 160 22   ?   ?   ?   R . n 
A 1 161 SER 161 23   ?   ?   ?   R . n 
A 1 162 MET 162 24   ?   ?   ?   R . n 
A 1 163 LYS 163 25   ?   ?   ?   R . n 
A 1 164 GLU 164 26   ?   ?   ?   R . n 
A 1 165 PRO 165 27   ?   ?   ?   R . n 
A 1 166 CYS 166 28   ?   ?   ?   R . n 
A 1 167 PHE 167 29   ?   ?   ?   R . n 
A 1 168 ARG 168 30   ?   ?   ?   R . n 
A 1 169 GLU 169 31   ?   ?   ?   R . n 
A 1 170 GLU 170 32   ?   ?   ?   R . n 
A 1 171 ASN 171 33   ?   ?   ?   R . n 
A 1 172 ALA 172 34   34  ALA ALA R . n 
A 1 173 ASN 173 35   35  ASN ASN R . n 
A 1 174 PHE 174 36   36  PHE PHE R . n 
A 1 175 ASN 175 37   37  ASN ASN R . n 
A 1 176 LYS 176 38   38  LYS LYS R . n 
A 1 177 ILE 177 39   39  ILE ILE R . n 
A 1 178 PHE 178 40   40  PHE PHE R . n 
A 1 179 LEU 179 41   41  LEU LEU R . n 
A 1 180 PRO 180 42   42  PRO PRO R . n 
A 1 181 THR 181 43   43  THR THR R . n 
A 1 182 ILE 182 44   44  ILE ILE R . n 
A 1 183 TYR 183 45   45  TYR TYR R . n 
A 1 184 SER 184 46   46  SER SER R . n 
A 1 185 ILE 185 47   47  ILE ILE R . n 
A 1 186 ILE 186 48   48  ILE ILE R . n 
A 1 187 PHE 187 49   49  PHE PHE R . n 
A 1 188 LEU 188 50   50  LEU LEU R . n 
A 1 189 THR 189 51   51  THR THR R . n 
A 1 190 GLY 190 52   52  GLY GLY R . n 
A 1 191 ILE 191 53   53  ILE ILE R . n 
A 1 192 VAL 192 54   54  VAL VAL R . n 
A 1 193 GLY 193 55   55  GLY GLY R . n 
A 1 194 ASN 194 56   56  ASN ASN R . n 
A 1 195 GLY 195 57   57  GLY GLY R . n 
A 1 196 LEU 196 58   58  LEU LEU R . n 
A 1 197 VAL 197 59   59  VAL VAL R . n 
A 1 198 ILE 198 60   60  ILE ILE R . n 
A 1 199 LEU 199 61   61  LEU LEU R . n 
A 1 200 VAL 200 62   62  VAL VAL R . n 
A 1 201 MET 201 63   63  MET MET R . n 
A 1 202 GLY 202 64   64  GLY GLY R . n 
A 1 203 TYR 203 65   65  TYR TYR R . n 
A 1 204 GLN 204 66   66  GLN GLN R . n 
A 1 205 LYS 205 67   67  LYS LYS R . n 
A 1 206 LYS 206 68   68  LYS LYS R . n 
A 1 207 LEU 207 69   69  LEU LEU R . n 
A 1 208 ARG 208 70   70  ARG ARG R . n 
A 1 209 SER 209 71   71  SER SER R . n 
A 1 210 MET 210 72   72  MET MET R . n 
A 1 211 THR 211 73   73  THR THR R . n 
A 1 212 ASP 212 74   74  ASP ASP R . n 
A 1 213 LYS 213 75   75  LYS LYS R . n 
A 1 214 TYR 214 76   76  TYR TYR R . n 
A 1 215 ARG 215 77   77  ARG ARG R . n 
A 1 216 LEU 216 78   78  LEU LEU R . n 
A 1 217 HIS 217 79   79  HIS HIS R . n 
A 1 218 LEU 218 80   80  LEU LEU R . n 
A 1 219 SER 219 81   81  SER SER R . n 
A 1 220 VAL 220 82   82  VAL VAL R . n 
A 1 221 ALA 221 83   83  ALA ALA R . n 
A 1 222 ASP 222 84   84  ASP ASP R . n 
A 1 223 LEU 223 85   85  LEU LEU R . n 
A 1 224 LEU 224 86   86  LEU LEU R . n 
A 1 225 PHE 225 87   87  PHE PHE R . n 
A 1 226 VAL 226 88   88  VAL VAL R . n 
A 1 227 ILE 227 89   89  ILE ILE R . n 
A 1 228 THR 228 90   90  THR THR R . n 
A 1 229 LEU 229 91   91  LEU LEU R . n 
A 1 230 PRO 230 92   92  PRO PRO R . n 
A 1 231 PHE 231 93   93  PHE PHE R . n 
A 1 232 TRP 232 94   94  TRP TRP R . n 
A 1 233 ALA 233 95   95  ALA ALA R . n 
A 1 234 VAL 234 96   96  VAL VAL R . n 
A 1 235 ASP 235 97   97  ASP ASP R . n 
A 1 236 ALA 236 98   98  ALA ALA R . n 
A 1 237 VAL 237 99   99  VAL VAL R . n 
A 1 238 ALA 238 100  100 ALA ALA R . n 
A 1 239 ASN 239 101  101 ASN ASN R . n 
A 1 240 TRP 240 102  102 TRP TRP R . n 
A 1 241 TYR 241 103  103 TYR TYR R . n 
A 1 242 PHE 242 104  104 PHE PHE R . n 
A 1 243 GLY 243 105  105 GLY GLY R . n 
A 1 244 ASN 244 106  106 ASN ASN R . n 
A 1 245 PHE 245 107  107 PHE PHE R . n 
A 1 246 LEU 246 108  108 LEU LEU R . n 
A 1 247 CYS 247 109  109 CYS CYS R . n 
A 1 248 LYS 248 110  110 LYS LYS R . n 
A 1 249 ALA 249 111  111 ALA ALA R . n 
A 1 250 VAL 250 112  112 VAL VAL R . n 
A 1 251 HIS 251 113  113 HIS HIS R . n 
A 1 252 VAL 252 114  114 VAL VAL R . n 
A 1 253 ILE 253 115  115 ILE ILE R . n 
A 1 254 TYR 254 116  116 TYR TYR R . n 
A 1 255 THR 255 117  117 THR THR R . n 
A 1 256 VAL 256 118  118 VAL VAL R . n 
A 1 257 ASN 257 119  119 ASN ASN R . n 
A 1 258 LEU 258 120  120 LEU LEU R . n 
A 1 259 TYR 259 121  121 TYR TYR R . n 
A 1 260 SER 260 122  122 SER SER R . n 
A 1 261 SER 261 123  123 SER SER R . n 
A 1 262 VAL 262 124  124 VAL VAL R . n 
A 1 263 TRP 263 125  125 TRP TRP R . n 
A 1 264 ILE 264 126  126 ILE ILE R . n 
A 1 265 LEU 265 127  127 LEU LEU R . n 
A 1 266 ALA 266 128  128 ALA ALA R . n 
A 1 267 PHE 267 129  129 PHE PHE R . n 
A 1 268 ILE 268 130  130 ILE ILE R . n 
A 1 269 SER 269 131  131 SER SER R . n 
A 1 270 LEU 270 132  132 LEU LEU R . n 
A 1 271 ASP 271 133  133 ASP ASP R . n 
A 1 272 ARG 272 134  134 ARG ARG R . n 
A 1 273 TYR 273 135  135 TYR TYR R . n 
A 1 274 LEU 274 136  136 LEU LEU R . n 
A 1 275 ALA 275 137  137 ALA ALA R . n 
A 1 276 ILE 276 138  138 ILE ILE R . n 
A 1 277 VAL 277 139  139 VAL VAL R . n 
A 1 278 HIS 278 140  140 HIS HIS R . n 
A 1 279 ALA 279 141  141 ALA ALA R . n 
A 1 280 THR 280 142  142 THR THR R . n 
A 1 281 ASN 281 143  143 ASN ASN R . n 
A 1 282 SER 282 144  144 SER SER R . n 
A 1 283 GLN 283 145  145 GLN GLN R . n 
A 1 284 ARG 284 146  146 ARG ARG R . n 
A 1 285 PRO 285 147  147 PRO PRO R . n 
A 1 286 ARG 286 148  148 ARG ARG R . n 
A 1 287 LYS 287 149  149 LYS LYS R . n 
A 1 288 LEU 288 150  150 LEU LEU R . n 
A 1 289 LEU 289 151  151 LEU LEU R . n 
A 1 290 ALA 290 152  152 ALA ALA R . n 
A 1 291 GLU 291 153  153 GLU GLU R . n 
A 1 292 LYS 292 154  154 LYS LYS R . n 
A 1 293 VAL 293 155  155 VAL VAL R . n 
A 1 294 VAL 294 156  156 VAL VAL R . n 
A 1 295 TYR 295 157  157 TYR TYR R . n 
A 1 296 VAL 296 158  158 VAL VAL R . n 
A 1 297 GLY 297 159  159 GLY GLY R . n 
A 1 298 VAL 298 160  160 VAL VAL R . n 
A 1 299 TRP 299 161  161 TRP TRP R . n 
A 1 300 ILE 300 162  162 ILE ILE R . n 
A 1 301 PRO 301 163  163 PRO PRO R . n 
A 1 302 ALA 302 164  164 ALA ALA R . n 
A 1 303 LEU 303 165  165 LEU LEU R . n 
A 1 304 LEU 304 166  166 LEU LEU R . n 
A 1 305 LEU 305 167  167 LEU LEU R . n 
A 1 306 THR 306 168  168 THR THR R . n 
A 1 307 ILE 307 169  169 ILE ILE R . n 
A 1 308 PRO 308 170  170 PRO PRO R . n 
A 1 309 ASP 309 171  171 ASP ASP R . n 
A 1 310 PHE 310 172  172 PHE PHE R . n 
A 1 311 ILE 311 173  173 ILE ILE R . n 
A 1 312 PHE 312 174  174 PHE PHE R . n 
A 1 313 ALA 313 175  175 ALA ALA R . n 
A 1 314 ASN 314 176  176 ASN ASN R . n 
A 1 315 VAL 315 177  177 VAL VAL R . n 
A 1 316 SER 316 178  178 SER SER R . n 
A 1 317 GLU 317 179  179 GLU GLU R . n 
A 1 318 ALA 318 180  180 ALA ALA R . n 
A 1 319 ASP 319 181  181 ASP ASP R . n 
A 1 320 ASP 320 182  182 ASP ASP R . n 
A 1 321 ARG 321 183  183 ARG ARG R . n 
A 1 322 TYR 322 184  184 TYR TYR R . n 
A 1 323 ILE 323 185  185 ILE ILE R . n 
A 1 324 CYS 324 186  186 CYS CYS R . n 
A 1 325 ASP 325 187  187 ASP ASP R . n 
A 1 326 ARG 326 188  188 ARG ARG R . n 
A 1 327 PHE 327 189  189 PHE PHE R . n 
A 1 328 TYR 328 190  190 TYR TYR R . n 
A 1 329 PRO 329 191  191 PRO PRO R . n 
A 1 330 ASN 330 192  192 ASN ASN R . n 
A 1 331 ASP 331 193  193 ASP ASP R . n 
A 1 332 LEU 332 194  194 LEU LEU R . n 
A 1 333 TRP 333 195  195 TRP TRP R . n 
A 1 334 VAL 334 196  196 VAL VAL R . n 
A 1 335 VAL 335 197  197 VAL VAL R . n 
A 1 336 VAL 336 198  198 VAL VAL R . n 
A 1 337 PHE 337 199  199 PHE PHE R . n 
A 1 338 GLN 338 200  200 GLN GLN R . n 
A 1 339 PHE 339 201  201 PHE PHE R . n 
A 1 340 GLN 340 202  202 GLN GLN R . n 
A 1 341 HIS 341 203  203 HIS HIS R . n 
A 1 342 ILE 342 204  204 ILE ILE R . n 
A 1 343 MET 343 205  205 MET MET R . n 
A 1 344 VAL 344 206  206 VAL VAL R . n 
A 1 345 GLY 345 207  207 GLY GLY R . n 
A 1 346 LEU 346 208  208 LEU LEU R . n 
A 1 347 ILE 347 209  209 ILE ILE R . n 
A 1 348 LEU 348 210  210 LEU LEU R . n 
A 1 349 PRO 349 211  211 PRO PRO R . n 
A 1 350 GLY 350 212  212 GLY GLY R . n 
A 1 351 ILE 351 213  213 ILE ILE R . n 
A 1 352 VAL 352 214  214 VAL VAL R . n 
A 1 353 ILE 353 215  215 ILE ILE R . n 
A 1 354 LEU 354 216  216 LEU LEU R . n 
A 1 355 SER 355 217  217 SER SER R . n 
A 1 356 CYS 356 218  218 CYS CYS R . n 
A 1 357 TYR 357 219  219 TYR TYR R . n 
A 1 358 CYS 358 220  220 CYS CYS R . n 
A 1 359 ILE 359 221  221 ILE ILE R . n 
A 1 360 ILE 360 222  222 ILE ILE R . n 
A 1 361 ILE 361 223  223 ILE ILE R . n 
A 1 362 SER 362 224  224 SER SER R . n 
A 1 363 ARG 363 225  225 ARG ARG R . n 
A 1 364 LEU 364 226  226 LEU LEU R . n 
A 1 365 LYS 365 227  227 LYS LYS R . n 
A 1 366 SER 366 228  228 SER SER R . n 
A 1 367 VAL 367 229  229 VAL VAL R . n 
A 1 368 ARG 368 230  230 ARG ARG R . n 
A 1 369 LEU 369 231  231 LEU LEU R . n 
A 1 370 LEU 370 232  232 LEU LEU R . n 
A 1 371 SER 371 233  233 SER SER R . n 
A 1 372 GLY 372 234  234 GLY GLY R . n 
A 1 373 SER 373 235  235 SER SER R . n 
A 1 374 ARG 374 236  236 ARG ARG R . n 
A 1 375 GLU 375 237  237 GLU GLU R . n 
A 1 376 LYS 376 238  238 LYS LYS R . n 
A 1 377 ASP 377 239  239 ASP ASP R . n 
A 1 378 ARG 378 240  240 ARG ARG R . n 
A 1 379 ASN 379 241  241 ASN ASN R . n 
A 1 380 LEU 380 242  242 LEU LEU R . n 
A 1 381 ARG 381 243  243 ARG ARG R . n 
A 1 382 ARG 382 244  244 ARG ARG R . n 
A 1 383 ILE 383 245  245 ILE ILE R . n 
A 1 384 THR 384 246  246 THR THR R . n 
A 1 385 ARG 385 247  247 ARG ARG R . n 
A 1 386 PRO 386 248  248 PRO PRO R . n 
A 1 387 THR 387 249  249 THR THR R . n 
A 1 388 VAL 388 250  250 VAL VAL R . n 
A 1 389 ILE 389 251  251 ILE ILE R . n 
A 1 390 LEU 390 252  252 LEU LEU R . n 
A 1 391 ILE 391 253  253 ILE ILE R . n 
A 1 392 LEU 392 254  254 LEU LEU R . n 
A 1 393 ALA 393 255  255 ALA ALA R . n 
A 1 394 PHE 394 256  256 PHE PHE R . n 
A 1 395 PHE 395 257  257 PHE PHE R . n 
A 1 396 ALA 396 258  258 ALA ALA R . n 
A 1 397 CYS 397 259  259 CYS CYS R . n 
A 1 398 TRP 398 260  260 TRP TRP R . n 
A 1 399 LEU 399 261  261 LEU LEU R . n 
A 1 400 PRO 400 262  262 PRO PRO R . n 
A 1 401 TYR 401 263  263 TYR TYR R . n 
A 1 402 TYR 402 264  264 TYR TYR R . n 
A 1 403 ILE 403 265  265 ILE ILE R . n 
A 1 404 GLY 404 266  266 GLY GLY R . n 
A 1 405 ILE 405 267  267 ILE ILE R . n 
A 1 406 SER 406 268  268 SER SER R . n 
A 1 407 ILE 407 269  269 ILE ILE R . n 
A 1 408 ASP 408 270  270 ASP ASP R . n 
A 1 409 SER 409 271  271 SER SER R . n 
A 1 410 PHE 410 272  272 PHE PHE R . n 
A 1 411 ILE 411 273  273 ILE ILE R . n 
A 1 412 LEU 412 274  274 LEU LEU R . n 
A 1 413 LEU 413 275  275 LEU LEU R . n 
A 1 414 GLU 414 276  276 GLU GLU R . n 
A 1 415 ILE 415 277  277 ILE ILE R . n 
A 1 416 ILE 416 278  278 ILE ILE R . n 
A 1 417 LYS 417 279  279 LYS LYS R . n 
A 1 418 GLN 418 280  280 GLN GLN R . n 
A 1 419 GLY 419 281  281 GLY GLY R . n 
A 1 420 CYS 420 282  282 CYS CYS R . n 
A 1 421 GLU 421 283  283 GLU GLU R . n 
A 1 422 PHE 422 284  284 PHE PHE R . n 
A 1 423 GLU 423 285  285 GLU GLU R . n 
A 1 424 ASN 424 286  286 ASN ASN R . n 
A 1 425 THR 425 287  287 THR THR R . n 
A 1 426 VAL 426 288  288 VAL VAL R . n 
A 1 427 HIS 427 289  289 HIS HIS R . n 
A 1 428 LYS 428 290  290 LYS LYS R . n 
A 1 429 TRP 429 291  291 TRP TRP R . n 
A 1 430 ILE 430 292  292 ILE ILE R . n 
A 1 431 SER 431 293  293 SER SER R . n 
A 1 432 ILE 432 294  294 ILE ILE R . n 
A 1 433 THR 433 295  295 THR THR R . n 
A 1 434 GLU 434 296  296 GLU GLU R . n 
A 1 435 ALA 435 297  297 ALA ALA R . n 
A 1 436 LEU 436 298  298 LEU LEU R . n 
A 1 437 ALA 437 299  299 ALA ALA R . n 
A 1 438 PHE 438 300  300 PHE PHE R . n 
A 1 439 PHE 439 301  301 PHE PHE R . n 
A 1 440 HIS 440 302  302 HIS HIS R . n 
A 1 441 CYS 441 303  303 CYS CYS R . n 
A 1 442 CYS 442 304  304 CYS CYS R . n 
A 1 443 LEU 443 305  305 LEU LEU R . n 
A 1 444 ASN 444 306  306 ASN ASN R . n 
A 1 445 PRO 445 307  307 PRO PRO R . n 
A 1 446 ILE 446 308  308 ILE ILE R . n 
A 1 447 LEU 447 309  309 LEU LEU R . n 
A 1 448 TYR 448 310  310 TYR TYR R . n 
A 1 449 ALA 449 311  311 ALA ALA R . n 
A 1 450 PHE 450 312  312 PHE PHE R . n 
A 1 451 LEU 451 313  313 LEU LEU R . n 
A 1 452 GLY 452 314  314 GLY GLY R . n 
A 1 453 ALA 453 315  315 ALA ALA R . n 
A 1 454 LYS 454 316  ?   ?   ?   R . n 
A 1 455 PHE 455 317  ?   ?   ?   R . n 
A 1 456 LYS 456 318  ?   ?   ?   R . n 
A 1 457 THR 457 319  ?   ?   ?   R . n 
A 1 458 SER 458 320  ?   ?   ?   R . n 
A 1 459 ALA 459 321  ?   ?   ?   R . n 
A 1 460 GLN 460 322  ?   ?   ?   R . n 
A 1 461 HIS 461 323  ?   ?   ?   R . n 
A 1 462 ALA 462 324  ?   ?   ?   R . n 
A 1 463 LEU 463 325  ?   ?   ?   R . n 
A 1 464 THR 464 326  ?   ?   ?   R . n 
A 1 465 SER 465 327  ?   ?   ?   R . n 
A 1 466 GLY 466 328  ?   ?   ?   R . n 
A 1 467 ARG 467 329  ?   ?   ?   R . n 
A 1 468 PRO 468 330  ?   ?   ?   R . n 
A 1 469 LEU 469 331  ?   ?   ?   R . n 
A 1 470 GLU 470 332  ?   ?   ?   R . n 
A 1 471 VAL 471 333  ?   ?   ?   R . n 
A 1 472 LEU 472 334  ?   ?   ?   R . n 
A 1 473 PHE 473 335  ?   ?   ?   R . n 
A 1 474 GLN 474 336  ?   ?   ?   R . n 
A 1 475 GLY 475 337  ?   ?   ?   R . n 
A 1 476 PRO 476 338  ?   ?   ?   R . n 
A 1 477 HIS 477 339  ?   ?   ?   R . n 
A 1 478 HIS 478 340  ?   ?   ?   R . n 
A 1 479 HIS 479 341  ?   ?   ?   R . n 
A 1 480 HIS 480 342  ?   ?   ?   R . n 
A 1 481 HIS 481 343  ?   ?   ?   R . n 
A 1 482 HIS 482 344  ?   ?   ?   R . n 
A 1 483 HIS 483 345  ?   ?   ?   R . n 
A 1 484 HIS 484 346  ?   ?   ?   R . n 
A 1 485 HIS 485 347  ?   ?   ?   R . n 
A 1 486 HIS 486 348  ?   ?   ?   R . n 
B 2 1   MET 1   -37  ?   ?   ?   N . n 
B 2 2   LEU 2   -36  ?   ?   ?   N . n 
B 2 3   LEU 3   -35  ?   ?   ?   N . n 
B 2 4   VAL 4   -34  ?   ?   ?   N . n 
B 2 5   ASN 5   -33  ?   ?   ?   N . n 
B 2 6   GLN 6   -32  ?   ?   ?   N . n 
B 2 7   SER 7   -31  ?   ?   ?   N . n 
B 2 8   HIS 8   -30  ?   ?   ?   N . n 
B 2 9   GLN 9   -29  ?   ?   ?   N . n 
B 2 10  GLY 10  -28  ?   ?   ?   N . n 
B 2 11  PHE 11  -27  ?   ?   ?   N . n 
B 2 12  ASN 12  -26  ?   ?   ?   N . n 
B 2 13  LYS 13  -25  ?   ?   ?   N . n 
B 2 14  GLU 14  -24  ?   ?   ?   N . n 
B 2 15  HIS 15  -23  ?   ?   ?   N . n 
B 2 16  THR 16  -22  ?   ?   ?   N . n 
B 2 17  SER 17  -21  ?   ?   ?   N . n 
B 2 18  LYS 18  -20  ?   ?   ?   N . n 
B 2 19  MET 19  -19  ?   ?   ?   N . n 
B 2 20  VAL 20  -18  ?   ?   ?   N . n 
B 2 21  SER 21  -17  ?   ?   ?   N . n 
B 2 22  ALA 22  -16  ?   ?   ?   N . n 
B 2 23  ILE 23  -15  ?   ?   ?   N . n 
B 2 24  VAL 24  -14  ?   ?   ?   N . n 
B 2 25  LEU 25  -13  ?   ?   ?   N . n 
B 2 26  TYR 26  -12  ?   ?   ?   N . n 
B 2 27  VAL 27  -11  ?   ?   ?   N . n 
B 2 28  LEU 28  -10  ?   ?   ?   N . n 
B 2 29  LEU 29  -9   ?   ?   ?   N . n 
B 2 30  ALA 30  -8   ?   ?   ?   N . n 
B 2 31  ALA 31  -7   ?   ?   ?   N . n 
B 2 32  ALA 32  -6   ?   ?   ?   N . n 
B 2 33  ALA 33  -5   ?   ?   ?   N . n 
B 2 34  HIS 34  -4   ?   ?   ?   N . n 
B 2 35  SER 35  -3   ?   ?   ?   N . n 
B 2 36  ALA 36  -2   ?   ?   ?   N . n 
B 2 37  PHE 37  -1   ?   ?   ?   N . n 
B 2 38  ALA 38  0    ?   ?   ?   N . n 
B 2 39  MET 39  1    ?   ?   ?   N . n 
B 2 40  ALA 40  2    ?   ?   ?   N . n 
B 2 41  GLN 41  3    3   GLN GLN N . n 
B 2 42  VAL 42  4    4   VAL VAL N . n 
B 2 43  GLN 43  5    5   GLN GLN N . n 
B 2 44  LEU 44  6    6   LEU LEU N . n 
B 2 45  GLN 45  7    7   GLN GLN N . n 
B 2 46  GLU 46  8    8   GLU GLU N . n 
B 2 47  SER 47  9    9   SER SER N . n 
B 2 48  GLY 48  10   10  GLY GLY N . n 
B 2 49  GLY 49  11   11  GLY GLY N . n 
B 2 50  GLY 50  12   12  GLY GLY N . n 
B 2 51  LEU 51  13   13  LEU LEU N . n 
B 2 52  VAL 52  14   14  VAL VAL N . n 
B 2 53  GLN 53  15   15  GLN GLN N . n 
B 2 54  ALA 54  16   16  ALA ALA N . n 
B 2 55  GLY 55  17   17  GLY GLY N . n 
B 2 56  GLU 56  18   18  GLU GLU N . n 
B 2 57  SER 57  19   19  SER SER N . n 
B 2 58  LEU 58  20   20  LEU LEU N . n 
B 2 59  ARG 59  21   21  ARG ARG N . n 
B 2 60  LEU 60  22   22  LEU LEU N . n 
B 2 61  SER 61  23   23  SER SER N . n 
B 2 62  CYS 62  24   24  CYS CYS N . n 
B 2 63  ALA 63  25   25  ALA ALA N . n 
B 2 64  ALA 64  26   26  ALA ALA N . n 
B 2 65  SER 65  27   27  SER SER N . n 
B 2 66  GLY 66  28   28  GLY GLY N . n 
B 2 67  THR 67  29   29  THR THR N . n 
B 2 68  ILE 68  30   30  ILE ILE N . n 
B 2 69  PHE 69  31   31  PHE PHE N . n 
B 2 70  ARG 70  32   32  ARG ARG N . n 
B 2 71  LEU 71  33   33  LEU LEU N . n 
B 2 72  TYR 72  34   34  TYR TYR N . n 
B 2 73  ASP 73  35   35  ASP ASP N . n 
B 2 74  MET 74  36   36  MET MET N . n 
B 2 75  GLY 75  37   37  GLY GLY N . n 
B 2 76  TRP 76  38   38  TRP TRP N . n 
B 2 77  TYR 77  39   39  TYR TYR N . n 
B 2 78  ARG 78  40   40  ARG ARG N . n 
B 2 79  ARG 79  41   ?   ?   ?   N . n 
B 2 80  VAL 80  42   ?   ?   ?   N . n 
B 2 81  SER 81  43   ?   ?   ?   N . n 
B 2 82  GLY 82  44   ?   ?   ?   N . n 
B 2 83  ASN 83  45   ?   ?   ?   N . n 
B 2 84  GLN 84  46   46  GLN GLN N . n 
B 2 85  ARG 85  47   47  ARG ARG N . n 
B 2 86  GLU 86  48   48  GLU GLU N . n 
B 2 87  LEU 87  49   49  LEU LEU N . n 
B 2 88  VAL 88  50   50  VAL VAL N . n 
B 2 89  ALA 89  51   51  ALA ALA N . n 
B 2 90  SER 90  52   52  SER SER N . n 
B 2 91  ILE 91  53   53  ILE ILE N . n 
B 2 92  THR 92  54   54  THR THR N . n 
B 2 93  SER 93  55   55  SER SER N . n 
B 2 94  GLY 94  56   56  GLY GLY N . n 
B 2 95  GLY 95  57   57  GLY GLY N . n 
B 2 96  SER 96  58   58  SER SER N . n 
B 2 97  THR 97  59   59  THR THR N . n 
B 2 98  LYS 98  60   60  LYS LYS N . n 
B 2 99  TYR 99  61   61  TYR TYR N . n 
B 2 100 GLY 100 62   62  GLY GLY N . n 
B 2 101 ASP 101 63   63  ASP ASP N . n 
B 2 102 SER 102 64   64  SER SER N . n 
B 2 103 VAL 103 65   65  VAL VAL N . n 
B 2 104 LYS 104 66   66  LYS LYS N . n 
B 2 105 GLY 105 67   67  GLY GLY N . n 
B 2 106 ARG 106 68   68  ARG ARG N . n 
B 2 107 PHE 107 69   69  PHE PHE N . n 
B 2 108 THR 108 70   70  THR THR N . n 
B 2 109 ILE 109 71   71  ILE ILE N . n 
B 2 110 SER 110 72   72  SER SER N . n 
B 2 111 ARG 111 73   73  ARG ARG N . n 
B 2 112 ASP 112 74   74  ASP ASP N . n 
B 2 113 ASN 113 75   75  ASN ASN N . n 
B 2 114 ALA 114 76   76  ALA ALA N . n 
B 2 115 LYS 115 77   77  LYS LYS N . n 
B 2 116 ASN 116 78   78  ASN ASN N . n 
B 2 117 THR 117 79   79  THR THR N . n 
B 2 118 VAL 118 80   80  VAL VAL N . n 
B 2 119 TYR 119 81   81  TYR TYR N . n 
B 2 120 LEU 120 82   82  LEU LEU N . n 
B 2 121 GLN 121 83   83  GLN GLN N . n 
B 2 122 MET 122 84   84  MET MET N . n 
B 2 123 SER 123 85   85  SER SER N . n 
B 2 124 SER 124 86   86  SER SER N . n 
B 2 125 LEU 125 87   87  LEU LEU N . n 
B 2 126 LYS 126 88   88  LYS LYS N . n 
B 2 127 PRO 127 89   89  PRO PRO N . n 
B 2 128 GLU 128 90   90  GLU GLU N . n 
B 2 129 ASP 129 91   91  ASP ASP N . n 
B 2 130 THR 130 92   92  THR THR N . n 
B 2 131 ALA 131 93   93  ALA ALA N . n 
B 2 132 VAL 132 94   94  VAL VAL N . n 
B 2 133 TYR 133 95   95  TYR TYR N . n 
B 2 134 TYR 134 96   96  TYR TYR N . n 
B 2 135 CYS 135 97   97  CYS CYS N . n 
B 2 136 ASN 136 98   98  ASN ASN N . n 
B 2 137 ALA 137 99   99  ALA ALA N . n 
B 2 138 GLU 138 100  100 GLU GLU N . n 
B 2 139 TYR 139 101  101 TYR TYR N . n 
B 2 140 ARG 140 102  102 ARG ARG N . n 
B 2 141 THR 141 103  103 THR THR N . n 
B 2 142 GLY 142 104  104 GLY GLY N . n 
B 2 143 ILE 143 105  105 ILE ILE N . n 
B 2 144 TRP 144 106  106 TRP TRP N . n 
B 2 145 GLU 145 107  107 GLU GLU N . n 
B 2 146 GLU 146 108  108 GLU GLU N . n 
B 2 147 LEU 147 109  109 LEU LEU N . n 
B 2 148 LEU 148 110  110 LEU LEU N . n 
B 2 149 ASP 149 111  111 ASP ASP N . n 
B 2 150 GLY 150 112  112 GLY GLY N . n 
B 2 151 TRP 151 113  113 TRP TRP N . n 
B 2 152 GLY 152 114  114 GLY GLY N . n 
B 2 153 GLN 153 115  115 GLN GLN N . n 
B 2 154 GLY 154 116  116 GLY GLY N . n 
B 2 155 THR 155 117  117 THR THR N . n 
B 2 156 GLN 156 118  118 GLN GLN N . n 
B 2 157 VAL 157 119  119 VAL VAL N . n 
B 2 158 THR 158 120  120 THR THR N . n 
B 2 159 VAL 159 121  121 VAL VAL N . n 
B 2 160 SER 160 122  122 SER SER N . n 
B 2 161 SER 161 123  123 SER SER N . n 
B 2 162 HIS 162 124  ?   ?   ?   N . n 
B 2 163 HIS 163 125  ?   ?   ?   N . n 
B 2 164 HIS 164 126  ?   ?   ?   N . n 
B 2 165 HIS 165 127  ?   ?   ?   N . n 
B 2 166 HIS 166 128  ?   ?   ?   N . n 
B 2 167 HIS 167 129  ?   ?   ?   N . n 
B 2 168 HIS 168 130  ?   ?   ?   N . n 
B 2 169 HIS 169 131  ?   ?   ?   N . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        VH6 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   VH6 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 CLR 1 401 402 CLR CLR R . 
D 4 VH6 1 402 1   VH6 VH6 R . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 N GLN 3   ? CG  ? B GLN 41  CG  
2  1 Y 1 N GLN 3   ? CD  ? B GLN 41  CD  
3  1 Y 1 N GLN 3   ? OE1 ? B GLN 41  OE1 
4  1 Y 1 N GLN 3   ? NE2 ? B GLN 41  NE2 
5  1 Y 1 N GLN 5   ? CG  ? B GLN 43  CG  
6  1 Y 1 N GLN 5   ? CD  ? B GLN 43  CD  
7  1 Y 1 N GLN 5   ? OE1 ? B GLN 43  OE1 
8  1 Y 1 N GLN 5   ? NE2 ? B GLN 43  NE2 
9  1 Y 1 N LEU 13  ? CG  ? B LEU 51  CG  
10 1 Y 1 N LEU 13  ? CD1 ? B LEU 51  CD1 
11 1 Y 1 N LEU 13  ? CD2 ? B LEU 51  CD2 
12 1 Y 1 N GLN 15  ? CG  ? B GLN 53  CG  
13 1 Y 1 N GLN 15  ? CD  ? B GLN 53  CD  
14 1 Y 1 N GLN 15  ? OE1 ? B GLN 53  OE1 
15 1 Y 1 N GLN 15  ? NE2 ? B GLN 53  NE2 
16 1 Y 1 N SER 27  ? OG  ? B SER 65  OG  
17 1 Y 1 N LEU 49  ? CG  ? B LEU 87  CG  
18 1 Y 1 N LEU 49  ? CD1 ? B LEU 87  CD1 
19 1 Y 1 N LEU 49  ? CD2 ? B LEU 87  CD2 
20 1 Y 1 N SER 52  ? OG  ? B SER 90  OG  
21 1 Y 1 N SER 58  ? OG  ? B SER 96  OG  
22 1 Y 1 N LYS 60  ? CG  ? B LYS 98  CG  
23 1 Y 1 N LYS 60  ? CD  ? B LYS 98  CD  
24 1 Y 1 N LYS 60  ? CE  ? B LYS 98  CE  
25 1 Y 1 N LYS 60  ? NZ  ? B LYS 98  NZ  
26 1 Y 1 N ASP 63  ? CG  ? B ASP 101 CG  
27 1 Y 1 N ASP 63  ? OD1 ? B ASP 101 OD1 
28 1 Y 1 N ASP 63  ? OD2 ? B ASP 101 OD2 
29 1 Y 1 N SER 64  ? OG  ? B SER 102 OG  
30 1 Y 1 N VAL 65  ? CG1 ? B VAL 103 CG1 
31 1 Y 1 N VAL 65  ? CG2 ? B VAL 103 CG2 
32 1 Y 1 N LYS 66  ? CG  ? B LYS 104 CG  
33 1 Y 1 N LYS 66  ? CD  ? B LYS 104 CD  
34 1 Y 1 N LYS 66  ? CE  ? B LYS 104 CE  
35 1 Y 1 N LYS 66  ? NZ  ? B LYS 104 NZ  
36 1 Y 1 N LYS 77  ? CG  ? B LYS 115 CG  
37 1 Y 1 N LYS 77  ? CD  ? B LYS 115 CD  
38 1 Y 1 N LYS 77  ? CE  ? B LYS 115 CE  
39 1 Y 1 N LYS 77  ? NZ  ? B LYS 115 NZ  
40 1 Y 1 N LYS 88  ? CG  ? B LYS 126 CG  
41 1 Y 1 N LYS 88  ? CD  ? B LYS 126 CD  
42 1 Y 1 N LYS 88  ? CE  ? B LYS 126 CE  
43 1 Y 1 N LYS 88  ? NZ  ? B LYS 126 NZ  
44 1 Y 1 N VAL 121 ? CG1 ? B VAL 159 CG1 
45 1 Y 1 N VAL 121 ? CG2 ? B VAL 159 CG2 
46 1 Y 1 N SER 122 ? OG  ? B SER 160 OG  
47 1 Y 1 N SER 123 ? OG  ? B SER 161 OG  
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZPN 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZPN 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZPN 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8ZPN 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003 ? 3286 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.524 ? 4473 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 5.428 ? 478  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.041 ? 516  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.005 ? 541  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8ZPN 
_struct.title                        'Cryo-EM strucutre of CXCR4 complexed with antagonist AMD3100' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZPN 
_struct_keywords.text            'CXC motif chemokine receptor 4, antagonist, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP C562_ECOLX  P0ABE7 ? 1 
;ADLEDNMETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLAN
EGKVKEAQAAAEQLKTTRNAYHQKY
;
23  
2 UNP CXCR4_HUMAN P61073 ? 1 
;MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHL
SVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGV
WIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIIS
;
1   
3 UNP CXCR4_HUMAN P61073 ? 1 TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTS 241 
4 PDB 8ZPN        8ZPN   ? 2 ? 1   
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZPN R 27  ? 131 ? P0ABE7 23  ? 127 ? -111 -7  
2 2 8ZPN R 139 ? 362 ? P61073 1   ? 224 ? 1    224 
3 3 8ZPN R 387 ? 465 ? P61073 241 ? 319 ? 249  327 
4 4 8ZPN N 1   ? 169 ? 8ZPN   -37 ? 131 ? -37  131 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZPN MET R 1   ? UNP P0ABE7 ?   ?   'initiating methionine' -137 1  
1 8ZPN LYS R 2   ? UNP P0ABE7 ?   ?   'expression tag'        -136 2  
1 8ZPN THR R 3   ? UNP P0ABE7 ?   ?   'expression tag'        -135 3  
1 8ZPN ILE R 4   ? UNP P0ABE7 ?   ?   'expression tag'        -134 4  
1 8ZPN ILE R 5   ? UNP P0ABE7 ?   ?   'expression tag'        -133 5  
1 8ZPN ALA R 6   ? UNP P0ABE7 ?   ?   'expression tag'        -132 6  
1 8ZPN LEU R 7   ? UNP P0ABE7 ?   ?   'expression tag'        -131 7  
1 8ZPN SER R 8   ? UNP P0ABE7 ?   ?   'expression tag'        -130 8  
1 8ZPN TYR R 9   ? UNP P0ABE7 ?   ?   'expression tag'        -129 9  
1 8ZPN ILE R 10  ? UNP P0ABE7 ?   ?   'expression tag'        -128 10 
1 8ZPN PHE R 11  ? UNP P0ABE7 ?   ?   'expression tag'        -127 11 
1 8ZPN CYS R 12  ? UNP P0ABE7 ?   ?   'expression tag'        -126 12 
1 8ZPN LEU R 13  ? UNP P0ABE7 ?   ?   'expression tag'        -125 13 
1 8ZPN VAL R 14  ? UNP P0ABE7 ?   ?   'expression tag'        -124 14 
1 8ZPN PHE R 15  ? UNP P0ABE7 ?   ?   'expression tag'        -123 15 
1 8ZPN ALA R 16  ? UNP P0ABE7 ?   ?   'expression tag'        -122 16 
1 8ZPN ASP R 17  ? UNP P0ABE7 ?   ?   'expression tag'        -121 17 
1 8ZPN TYR R 18  ? UNP P0ABE7 ?   ?   'expression tag'        -120 18 
1 8ZPN LYS R 19  ? UNP P0ABE7 ?   ?   'expression tag'        -119 19 
1 8ZPN ASP R 20  ? UNP P0ABE7 ?   ?   'expression tag'        -118 20 
1 8ZPN ASP R 21  ? UNP P0ABE7 ?   ?   'expression tag'        -117 21 
1 8ZPN ASP R 22  ? UNP P0ABE7 ?   ?   'expression tag'        -116 22 
1 8ZPN ASP R 23  ? UNP P0ABE7 ?   ?   'expression tag'        -115 23 
1 8ZPN LYS R 24  ? UNP P0ABE7 ?   ?   'expression tag'        -114 24 
1 8ZPN GLY R 25  ? UNP P0ABE7 ?   ?   'expression tag'        -113 25 
1 8ZPN SER R 26  ? UNP P0ABE7 ?   ?   'expression tag'        -112 26 
1 8ZPN TRP R 33  ? UNP P0ABE7 MET 29  conflict                -105 27 
1 8ZPN ILE R 128 ? UNP P0ABE7 HIS 124 conflict                -10  28 
1 8ZPN LEU R 132 ? UNP P0ABE7 ?   ?   linker                  -6   29 
1 8ZPN LEU R 133 ? UNP P0ABE7 ?   ?   linker                  -5   30 
1 8ZPN VAL R 134 ? UNP P0ABE7 ?   ?   linker                  -4   31 
1 8ZPN PRO R 135 ? UNP P0ABE7 ?   ?   linker                  -3   32 
1 8ZPN ARG R 136 ? UNP P0ABE7 ?   ?   linker                  -2   33 
1 8ZPN GLY R 137 ? UNP P0ABE7 ?   ?   linker                  -1   34 
1 8ZPN SER R 138 ? UNP P0ABE7 ?   ?   linker                  0    35 
2 8ZPN TRP R 263 ? UNP P61073 LEU 125 conflict                125  36 
2 8ZPN ARG R 363 ? UNP P61073 ?   ?   linker                  225  37 
2 8ZPN LEU R 364 ? UNP P61073 ?   ?   linker                  226  38 
2 8ZPN LYS R 365 ? UNP P61073 ?   ?   linker                  227  39 
2 8ZPN SER R 366 ? UNP P61073 ?   ?   linker                  228  40 
2 8ZPN VAL R 367 ? UNP P61073 ?   ?   linker                  229  41 
2 8ZPN ARG R 368 ? UNP P61073 ?   ?   linker                  230  42 
2 8ZPN LEU R 369 ? UNP P61073 ?   ?   linker                  231  43 
2 8ZPN LEU R 370 ? UNP P61073 ?   ?   linker                  232  44 
2 8ZPN SER R 371 ? UNP P61073 ?   ?   linker                  233  45 
2 8ZPN GLY R 372 ? UNP P61073 ?   ?   linker                  234  46 
2 8ZPN SER R 373 ? UNP P61073 ?   ?   linker                  235  47 
2 8ZPN ARG R 374 ? UNP P61073 ?   ?   linker                  236  48 
2 8ZPN GLU R 375 ? UNP P61073 ?   ?   linker                  237  49 
2 8ZPN LYS R 376 ? UNP P61073 ?   ?   linker                  238  50 
2 8ZPN ASP R 377 ? UNP P61073 ?   ?   linker                  239  51 
2 8ZPN ARG R 378 ? UNP P61073 ?   ?   linker                  240  52 
2 8ZPN ASN R 379 ? UNP P61073 ?   ?   linker                  241  53 
2 8ZPN LEU R 380 ? UNP P61073 ?   ?   linker                  242  54 
2 8ZPN ARG R 381 ? UNP P61073 ?   ?   linker                  243  55 
2 8ZPN ARG R 382 ? UNP P61073 ?   ?   linker                  244  56 
2 8ZPN ILE R 383 ? UNP P61073 ?   ?   linker                  245  57 
2 8ZPN THR R 384 ? UNP P61073 ?   ?   linker                  246  58 
2 8ZPN ARG R 385 ? UNP P61073 ?   ?   linker                  247  59 
2 8ZPN PRO R 386 ? UNP P61073 ?   ?   linker                  248  60 
3 8ZPN GLY R 466 ? UNP P61073 ?   ?   'expression tag'        328  61 
3 8ZPN ARG R 467 ? UNP P61073 ?   ?   'expression tag'        329  62 
3 8ZPN PRO R 468 ? UNP P61073 ?   ?   'expression tag'        330  63 
3 8ZPN LEU R 469 ? UNP P61073 ?   ?   'expression tag'        331  64 
3 8ZPN GLU R 470 ? UNP P61073 ?   ?   'expression tag'        332  65 
3 8ZPN VAL R 471 ? UNP P61073 ?   ?   'expression tag'        333  66 
3 8ZPN LEU R 472 ? UNP P61073 ?   ?   'expression tag'        334  67 
3 8ZPN PHE R 473 ? UNP P61073 ?   ?   'expression tag'        335  68 
3 8ZPN GLN R 474 ? UNP P61073 ?   ?   'expression tag'        336  69 
3 8ZPN GLY R 475 ? UNP P61073 ?   ?   'expression tag'        337  70 
3 8ZPN PRO R 476 ? UNP P61073 ?   ?   'expression tag'        338  71 
3 8ZPN HIS R 477 ? UNP P61073 ?   ?   'expression tag'        339  72 
3 8ZPN HIS R 478 ? UNP P61073 ?   ?   'expression tag'        340  73 
3 8ZPN HIS R 479 ? UNP P61073 ?   ?   'expression tag'        341  74 
3 8ZPN HIS R 480 ? UNP P61073 ?   ?   'expression tag'        342  75 
3 8ZPN HIS R 481 ? UNP P61073 ?   ?   'expression tag'        343  76 
3 8ZPN HIS R 482 ? UNP P61073 ?   ?   'expression tag'        344  77 
3 8ZPN HIS R 483 ? UNP P61073 ?   ?   'expression tag'        345  78 
3 8ZPN HIS R 484 ? UNP P61073 ?   ?   'expression tag'        346  79 
3 8ZPN HIS R 485 ? UNP P61073 ?   ?   'expression tag'        347  80 
3 8ZPN HIS R 486 ? UNP P61073 ?   ?   'expression tag'        348  81 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 172 ? TYR A 203 ? ALA R 34  TYR R 65  1 ? 32 
HELX_P HELX_P2  AA2 SER A 209 ? ALA A 238 ? SER R 71  ALA R 100 1 ? 30 
HELX_P HELX_P3  AA3 GLY A 243 ? HIS A 278 ? GLY R 105 HIS R 140 1 ? 36 
HELX_P HELX_P4  AA4 GLN A 283 ? LYS A 292 ? GLN R 145 LYS R 154 1 ? 10 
HELX_P HELX_P5  AA5 VAL A 293 ? LEU A 305 ? VAL R 155 LEU R 167 1 ? 13 
HELX_P HELX_P6  AA6 THR A 306 ? PHE A 312 ? THR R 168 PHE R 174 1 ? 7  
HELX_P HELX_P7  AA7 ASN A 330 ? LYS A 365 ? ASN R 192 LYS R 227 1 ? 36 
HELX_P HELX_P8  AA8 SER A 373 ? LEU A 413 ? SER R 235 LEU R 275 1 ? 41 
HELX_P HELX_P9  AA9 GLY A 419 ? PHE A 438 ? GLY R 281 PHE R 300 1 ? 20 
HELX_P HELX_P10 AB1 PHE A 439 ? CYS A 441 ? PHE R 301 CYS R 303 5 ? 3  
HELX_P HELX_P11 AB2 CYS A 442 ? LEU A 451 ? CYS R 304 LEU R 313 1 ? 10 
HELX_P HELX_P12 AB3 LYS B 126 ? THR B 130 ? LYS N 88  THR N 92  5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 247 SG ? ? ? 1_555 A CYS 324 SG ? ? R CYS 109 R CYS 186 1_555 ? ? ? ? ? ? ? 2.030 ? ? 
disulf2 disulf ? ? B CYS 62  SG ? ? ? 1_555 B CYS 135 SG ? ? N CYS 24  N CYS 97  1_555 ? ? ? ? ? ? ? 2.032 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 247 ? CYS A 324 ? CYS R 109 ? 1_555 CYS R 186 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS B 62  ? CYS B 135 ? CYS N 24  ? 1_555 CYS N 97  ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 2 ? 
AA3 ? 5 ? 
AA4 ? 4 ? 
AA5 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA4 1 2 ? parallel      
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 313 ? VAL A 315 ? ALA R 175 VAL R 177 
AA1 2 CYS A 324 ? ARG A 326 ? CYS R 186 ARG R 188 
AA2 1 VAL B 42  ? LEU B 44  ? VAL N 4   LEU N 6   
AA2 2 ALA B 64  ? GLY B 66  ? ALA N 26  GLY N 28  
AA3 1 GLY B 50  ? VAL B 52  ? GLY N 12  VAL N 14  
AA3 2 THR B 155 ? VAL B 159 ? THR N 117 VAL N 121 
AA3 3 ALA B 131 ? ARG B 140 ? ALA N 93  ARG N 102 
AA3 4 ARG B 70  ? ARG B 78  ? ARG N 32  ARG N 40  
AA3 5 GLU B 86  ? THR B 92  ? GLU N 48  THR N 54  
AA4 1 GLY B 50  ? VAL B 52  ? GLY N 12  VAL N 14  
AA4 2 THR B 155 ? VAL B 159 ? THR N 117 VAL N 121 
AA4 3 ALA B 131 ? ARG B 140 ? ALA N 93  ARG N 102 
AA4 4 LEU B 148 ? TRP B 151 ? LEU N 110 TRP N 113 
AA5 1 ARG B 59  ? LEU B 60  ? ARG N 21  LEU N 22  
AA5 2 THR B 117 ? GLN B 121 ? THR N 79  GLN N 83  
AA5 3 THR B 108 ? ASP B 112 ? THR N 70  ASP N 74  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ASN A 314 ? N ASN R 176 O ASP A 325 ? O ASP R 187 
AA2 1 2 N GLN B 43  ? N GLN N 5   O SER B 65  ? O SER N 27  
AA3 1 2 N GLY B 50  ? N GLY N 12  O GLN B 156 ? O GLN N 118 
AA3 2 3 O THR B 155 ? O THR N 117 N TYR B 133 ? N TYR N 95  
AA3 3 4 O ASN B 136 ? O ASN N 98  N GLY B 75  ? N GLY N 37  
AA3 4 5 N ARG B 78  ? N ARG N 40  O GLU B 86  ? O GLU N 48  
AA4 1 2 N GLY B 50  ? N GLY N 12  O GLN B 156 ? O GLN N 118 
AA4 2 3 O THR B 155 ? O THR N 117 N TYR B 133 ? N TYR N 95  
AA4 3 4 N TYR B 139 ? N TYR N 101 O LEU B 148 ? O LEU N 110 
AA5 1 2 N LEU B 60  ? N LEU N 22  O LEU B 120 ? O LEU N 82  
AA5 2 3 O GLN B 121 ? O GLN N 83  N THR B 108 ? N THR N 70  
# 
_pdbx_entry_details.entry_id                   8ZPN 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA R 100 ? ? -122.13 -55.91  
2 1 PRO R 147 ? ? -84.56  40.21   
3 1 ALA R 180 ? ? -67.96  -179.92 
4 1 ASP R 182 ? ? 59.57   -95.10  
5 1 SER R 233 ? ? 58.72   -127.99 
6 1 ILE R 277 ? ? -126.16 -54.23  
7 1 PHE R 300 ? ? -65.56  0.65    
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8ZPN 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8ZPN 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.31 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               90157 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               'MULTIPLE SOURCES' 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 AMD3100-CXCR4-KOR-Nb6 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2' 
# 
_em_imaging.entry_id                        8ZPN 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1500 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8ZPN 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8ZPN 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 R MET -137 ? A MET 1   
2   1 Y 1 R LYS -136 ? A LYS 2   
3   1 Y 1 R THR -135 ? A THR 3   
4   1 Y 1 R ILE -134 ? A ILE 4   
5   1 Y 1 R ILE -133 ? A ILE 5   
6   1 Y 1 R ALA -132 ? A ALA 6   
7   1 Y 1 R LEU -131 ? A LEU 7   
8   1 Y 1 R SER -130 ? A SER 8   
9   1 Y 1 R TYR -129 ? A TYR 9   
10  1 Y 1 R ILE -128 ? A ILE 10  
11  1 Y 1 R PHE -127 ? A PHE 11  
12  1 Y 1 R CYS -126 ? A CYS 12  
13  1 Y 1 R LEU -125 ? A LEU 13  
14  1 Y 1 R VAL -124 ? A VAL 14  
15  1 Y 1 R PHE -123 ? A PHE 15  
16  1 Y 1 R ALA -122 ? A ALA 16  
17  1 Y 1 R ASP -121 ? A ASP 17  
18  1 Y 1 R TYR -120 ? A TYR 18  
19  1 Y 1 R LYS -119 ? A LYS 19  
20  1 Y 1 R ASP -118 ? A ASP 20  
21  1 Y 1 R ASP -117 ? A ASP 21  
22  1 Y 1 R ASP -116 ? A ASP 22  
23  1 Y 1 R ASP -115 ? A ASP 23  
24  1 Y 1 R LYS -114 ? A LYS 24  
25  1 Y 1 R GLY -113 ? A GLY 25  
26  1 Y 1 R SER -112 ? A SER 26  
27  1 Y 1 R ALA -111 ? A ALA 27  
28  1 Y 1 R ASP -110 ? A ASP 28  
29  1 Y 1 R LEU -109 ? A LEU 29  
30  1 Y 1 R GLU -108 ? A GLU 30  
31  1 Y 1 R ASP -107 ? A ASP 31  
32  1 Y 1 R ASN -106 ? A ASN 32  
33  1 Y 1 R TRP -105 ? A TRP 33  
34  1 Y 1 R GLU -104 ? A GLU 34  
35  1 Y 1 R THR -103 ? A THR 35  
36  1 Y 1 R LEU -102 ? A LEU 36  
37  1 Y 1 R ASN -101 ? A ASN 37  
38  1 Y 1 R ASP -100 ? A ASP 38  
39  1 Y 1 R ASN -99  ? A ASN 39  
40  1 Y 1 R LEU -98  ? A LEU 40  
41  1 Y 1 R LYS -97  ? A LYS 41  
42  1 Y 1 R VAL -96  ? A VAL 42  
43  1 Y 1 R ILE -95  ? A ILE 43  
44  1 Y 1 R GLU -94  ? A GLU 44  
45  1 Y 1 R LYS -93  ? A LYS 45  
46  1 Y 1 R ALA -92  ? A ALA 46  
47  1 Y 1 R ASP -91  ? A ASP 47  
48  1 Y 1 R ASN -90  ? A ASN 48  
49  1 Y 1 R ALA -89  ? A ALA 49  
50  1 Y 1 R ALA -88  ? A ALA 50  
51  1 Y 1 R GLN -87  ? A GLN 51  
52  1 Y 1 R VAL -86  ? A VAL 52  
53  1 Y 1 R LYS -85  ? A LYS 53  
54  1 Y 1 R ASP -84  ? A ASP 54  
55  1 Y 1 R ALA -83  ? A ALA 55  
56  1 Y 1 R LEU -82  ? A LEU 56  
57  1 Y 1 R THR -81  ? A THR 57  
58  1 Y 1 R LYS -80  ? A LYS 58  
59  1 Y 1 R MET -79  ? A MET 59  
60  1 Y 1 R ARG -78  ? A ARG 60  
61  1 Y 1 R ALA -77  ? A ALA 61  
62  1 Y 1 R ALA -76  ? A ALA 62  
63  1 Y 1 R ALA -75  ? A ALA 63  
64  1 Y 1 R LEU -74  ? A LEU 64  
65  1 Y 1 R ASP -73  ? A ASP 65  
66  1 Y 1 R ALA -72  ? A ALA 66  
67  1 Y 1 R GLN -71  ? A GLN 67  
68  1 Y 1 R LYS -70  ? A LYS 68  
69  1 Y 1 R ALA -69  ? A ALA 69  
70  1 Y 1 R THR -68  ? A THR 70  
71  1 Y 1 R PRO -67  ? A PRO 71  
72  1 Y 1 R PRO -66  ? A PRO 72  
73  1 Y 1 R LYS -65  ? A LYS 73  
74  1 Y 1 R LEU -64  ? A LEU 74  
75  1 Y 1 R GLU -63  ? A GLU 75  
76  1 Y 1 R ASP -62  ? A ASP 76  
77  1 Y 1 R LYS -61  ? A LYS 77  
78  1 Y 1 R SER -60  ? A SER 78  
79  1 Y 1 R PRO -59  ? A PRO 79  
80  1 Y 1 R ASP -58  ? A ASP 80  
81  1 Y 1 R SER -57  ? A SER 81  
82  1 Y 1 R PRO -56  ? A PRO 82  
83  1 Y 1 R GLU -55  ? A GLU 83  
84  1 Y 1 R MET -54  ? A MET 84  
85  1 Y 1 R LYS -53  ? A LYS 85  
86  1 Y 1 R ASP -52  ? A ASP 86  
87  1 Y 1 R PHE -51  ? A PHE 87  
88  1 Y 1 R ARG -50  ? A ARG 88  
89  1 Y 1 R HIS -49  ? A HIS 89  
90  1 Y 1 R GLY -48  ? A GLY 90  
91  1 Y 1 R PHE -47  ? A PHE 91  
92  1 Y 1 R ASP -46  ? A ASP 92  
93  1 Y 1 R ILE -45  ? A ILE 93  
94  1 Y 1 R LEU -44  ? A LEU 94  
95  1 Y 1 R VAL -43  ? A VAL 95  
96  1 Y 1 R GLY -42  ? A GLY 96  
97  1 Y 1 R GLN -41  ? A GLN 97  
98  1 Y 1 R ILE -40  ? A ILE 98  
99  1 Y 1 R ASP -39  ? A ASP 99  
100 1 Y 1 R ASP -38  ? A ASP 100 
101 1 Y 1 R ALA -37  ? A ALA 101 
102 1 Y 1 R LEU -36  ? A LEU 102 
103 1 Y 1 R LYS -35  ? A LYS 103 
104 1 Y 1 R LEU -34  ? A LEU 104 
105 1 Y 1 R ALA -33  ? A ALA 105 
106 1 Y 1 R ASN -32  ? A ASN 106 
107 1 Y 1 R GLU -31  ? A GLU 107 
108 1 Y 1 R GLY -30  ? A GLY 108 
109 1 Y 1 R LYS -29  ? A LYS 109 
110 1 Y 1 R VAL -28  ? A VAL 110 
111 1 Y 1 R LYS -27  ? A LYS 111 
112 1 Y 1 R GLU -26  ? A GLU 112 
113 1 Y 1 R ALA -25  ? A ALA 113 
114 1 Y 1 R GLN -24  ? A GLN 114 
115 1 Y 1 R ALA -23  ? A ALA 115 
116 1 Y 1 R ALA -22  ? A ALA 116 
117 1 Y 1 R ALA -21  ? A ALA 117 
118 1 Y 1 R GLU -20  ? A GLU 118 
119 1 Y 1 R GLN -19  ? A GLN 119 
120 1 Y 1 R LEU -18  ? A LEU 120 
121 1 Y 1 R LYS -17  ? A LYS 121 
122 1 Y 1 R THR -16  ? A THR 122 
123 1 Y 1 R THR -15  ? A THR 123 
124 1 Y 1 R ARG -14  ? A ARG 124 
125 1 Y 1 R ASN -13  ? A ASN 125 
126 1 Y 1 R ALA -12  ? A ALA 126 
127 1 Y 1 R TYR -11  ? A TYR 127 
128 1 Y 1 R ILE -10  ? A ILE 128 
129 1 Y 1 R GLN -9   ? A GLN 129 
130 1 Y 1 R LYS -8   ? A LYS 130 
131 1 Y 1 R TYR -7   ? A TYR 131 
132 1 Y 1 R LEU -6   ? A LEU 132 
133 1 Y 1 R LEU -5   ? A LEU 133 
134 1 Y 1 R VAL -4   ? A VAL 134 
135 1 Y 1 R PRO -3   ? A PRO 135 
136 1 Y 1 R ARG -2   ? A ARG 136 
137 1 Y 1 R GLY -1   ? A GLY 137 
138 1 Y 1 R SER 0    ? A SER 138 
139 1 Y 1 R MET 1    ? A MET 139 
140 1 Y 1 R GLU 2    ? A GLU 140 
141 1 Y 1 R GLY 3    ? A GLY 141 
142 1 Y 1 R ILE 4    ? A ILE 142 
143 1 Y 1 R SER 5    ? A SER 143 
144 1 Y 1 R ILE 6    ? A ILE 144 
145 1 Y 1 R TYR 7    ? A TYR 145 
146 1 Y 1 R THR 8    ? A THR 146 
147 1 Y 1 R SER 9    ? A SER 147 
148 1 Y 1 R ASP 10   ? A ASP 148 
149 1 Y 1 R ASN 11   ? A ASN 149 
150 1 Y 1 R TYR 12   ? A TYR 150 
151 1 Y 1 R THR 13   ? A THR 151 
152 1 Y 1 R GLU 14   ? A GLU 152 
153 1 Y 1 R GLU 15   ? A GLU 153 
154 1 Y 1 R MET 16   ? A MET 154 
155 1 Y 1 R GLY 17   ? A GLY 155 
156 1 Y 1 R SER 18   ? A SER 156 
157 1 Y 1 R GLY 19   ? A GLY 157 
158 1 Y 1 R ASP 20   ? A ASP 158 
159 1 Y 1 R TYR 21   ? A TYR 159 
160 1 Y 1 R ASP 22   ? A ASP 160 
161 1 Y 1 R SER 23   ? A SER 161 
162 1 Y 1 R MET 24   ? A MET 162 
163 1 Y 1 R LYS 25   ? A LYS 163 
164 1 Y 1 R GLU 26   ? A GLU 164 
165 1 Y 1 R PRO 27   ? A PRO 165 
166 1 Y 1 R CYS 28   ? A CYS 166 
167 1 Y 1 R PHE 29   ? A PHE 167 
168 1 Y 1 R ARG 30   ? A ARG 168 
169 1 Y 1 R GLU 31   ? A GLU 169 
170 1 Y 1 R GLU 32   ? A GLU 170 
171 1 Y 1 R ASN 33   ? A ASN 171 
172 1 Y 1 R LYS 316  ? A LYS 454 
173 1 Y 1 R PHE 317  ? A PHE 455 
174 1 Y 1 R LYS 318  ? A LYS 456 
175 1 Y 1 R THR 319  ? A THR 457 
176 1 Y 1 R SER 320  ? A SER 458 
177 1 Y 1 R ALA 321  ? A ALA 459 
178 1 Y 1 R GLN 322  ? A GLN 460 
179 1 Y 1 R HIS 323  ? A HIS 461 
180 1 Y 1 R ALA 324  ? A ALA 462 
181 1 Y 1 R LEU 325  ? A LEU 463 
182 1 Y 1 R THR 326  ? A THR 464 
183 1 Y 1 R SER 327  ? A SER 465 
184 1 Y 1 R GLY 328  ? A GLY 466 
185 1 Y 1 R ARG 329  ? A ARG 467 
186 1 Y 1 R PRO 330  ? A PRO 468 
187 1 Y 1 R LEU 331  ? A LEU 469 
188 1 Y 1 R GLU 332  ? A GLU 470 
189 1 Y 1 R VAL 333  ? A VAL 471 
190 1 Y 1 R LEU 334  ? A LEU 472 
191 1 Y 1 R PHE 335  ? A PHE 473 
192 1 Y 1 R GLN 336  ? A GLN 474 
193 1 Y 1 R GLY 337  ? A GLY 475 
194 1 Y 1 R PRO 338  ? A PRO 476 
195 1 Y 1 R HIS 339  ? A HIS 477 
196 1 Y 1 R HIS 340  ? A HIS 478 
197 1 Y 1 R HIS 341  ? A HIS 479 
198 1 Y 1 R HIS 342  ? A HIS 480 
199 1 Y 1 R HIS 343  ? A HIS 481 
200 1 Y 1 R HIS 344  ? A HIS 482 
201 1 Y 1 R HIS 345  ? A HIS 483 
202 1 Y 1 R HIS 346  ? A HIS 484 
203 1 Y 1 R HIS 347  ? A HIS 485 
204 1 Y 1 R HIS 348  ? A HIS 486 
205 1 Y 1 N MET -37  ? B MET 1   
206 1 Y 1 N LEU -36  ? B LEU 2   
207 1 Y 1 N LEU -35  ? B LEU 3   
208 1 Y 1 N VAL -34  ? B VAL 4   
209 1 Y 1 N ASN -33  ? B ASN 5   
210 1 Y 1 N GLN -32  ? B GLN 6   
211 1 Y 1 N SER -31  ? B SER 7   
212 1 Y 1 N HIS -30  ? B HIS 8   
213 1 Y 1 N GLN -29  ? B GLN 9   
214 1 Y 1 N GLY -28  ? B GLY 10  
215 1 Y 1 N PHE -27  ? B PHE 11  
216 1 Y 1 N ASN -26  ? B ASN 12  
217 1 Y 1 N LYS -25  ? B LYS 13  
218 1 Y 1 N GLU -24  ? B GLU 14  
219 1 Y 1 N HIS -23  ? B HIS 15  
220 1 Y 1 N THR -22  ? B THR 16  
221 1 Y 1 N SER -21  ? B SER 17  
222 1 Y 1 N LYS -20  ? B LYS 18  
223 1 Y 1 N MET -19  ? B MET 19  
224 1 Y 1 N VAL -18  ? B VAL 20  
225 1 Y 1 N SER -17  ? B SER 21  
226 1 Y 1 N ALA -16  ? B ALA 22  
227 1 Y 1 N ILE -15  ? B ILE 23  
228 1 Y 1 N VAL -14  ? B VAL 24  
229 1 Y 1 N LEU -13  ? B LEU 25  
230 1 Y 1 N TYR -12  ? B TYR 26  
231 1 Y 1 N VAL -11  ? B VAL 27  
232 1 Y 1 N LEU -10  ? B LEU 28  
233 1 Y 1 N LEU -9   ? B LEU 29  
234 1 Y 1 N ALA -8   ? B ALA 30  
235 1 Y 1 N ALA -7   ? B ALA 31  
236 1 Y 1 N ALA -6   ? B ALA 32  
237 1 Y 1 N ALA -5   ? B ALA 33  
238 1 Y 1 N HIS -4   ? B HIS 34  
239 1 Y 1 N SER -3   ? B SER 35  
240 1 Y 1 N ALA -2   ? B ALA 36  
241 1 Y 1 N PHE -1   ? B PHE 37  
242 1 Y 1 N ALA 0    ? B ALA 38  
243 1 Y 1 N MET 1    ? B MET 39  
244 1 Y 1 N ALA 2    ? B ALA 40  
245 1 Y 1 N ARG 41   ? B ARG 79  
246 1 Y 1 N VAL 42   ? B VAL 80  
247 1 Y 1 N SER 43   ? B SER 81  
248 1 Y 1 N GLY 44   ? B GLY 82  
249 1 Y 1 N ASN 45   ? B ASN 83  
250 1 Y 1 N HIS 124  ? B HIS 162 
251 1 Y 1 N HIS 125  ? B HIS 163 
252 1 Y 1 N HIS 126  ? B HIS 164 
253 1 Y 1 N HIS 127  ? B HIS 165 
254 1 Y 1 N HIS 128  ? B HIS 166 
255 1 Y 1 N HIS 129  ? B HIS 167 
256 1 Y 1 N HIS 130  ? B HIS 168 
257 1 Y 1 N HIS 131  ? B HIS 169 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CLR C1   C N N 74  
CLR C2   C N N 75  
CLR C3   C N S 76  
CLR C4   C N N 77  
CLR C5   C N N 78  
CLR C6   C N N 79  
CLR C7   C N N 80  
CLR C8   C N S 81  
CLR C9   C N S 82  
CLR C10  C N R 83  
CLR C11  C N N 84  
CLR C12  C N N 85  
CLR C13  C N R 86  
CLR C14  C N S 87  
CLR C15  C N N 88  
CLR C16  C N N 89  
CLR C17  C N R 90  
CLR C18  C N N 91  
CLR C19  C N N 92  
CLR C20  C N R 93  
CLR C21  C N N 94  
CLR C22  C N N 95  
CLR C23  C N N 96  
CLR C24  C N N 97  
CLR C25  C N N 98  
CLR C26  C N N 99  
CLR C27  C N N 100 
CLR O1   O N N 101 
CLR H11  H N N 102 
CLR H12  H N N 103 
CLR H21  H N N 104 
CLR H22  H N N 105 
CLR H3   H N N 106 
CLR H41  H N N 107 
CLR H42  H N N 108 
CLR H6   H N N 109 
CLR H71  H N N 110 
CLR H72  H N N 111 
CLR H8   H N N 112 
CLR H9   H N N 113 
CLR H111 H N N 114 
CLR H112 H N N 115 
CLR H121 H N N 116 
CLR H122 H N N 117 
CLR H14  H N N 118 
CLR H151 H N N 119 
CLR H152 H N N 120 
CLR H161 H N N 121 
CLR H162 H N N 122 
CLR H17  H N N 123 
CLR H181 H N N 124 
CLR H182 H N N 125 
CLR H183 H N N 126 
CLR H191 H N N 127 
CLR H192 H N N 128 
CLR H193 H N N 129 
CLR H20  H N N 130 
CLR H211 H N N 131 
CLR H212 H N N 132 
CLR H213 H N N 133 
CLR H221 H N N 134 
CLR H222 H N N 135 
CLR H231 H N N 136 
CLR H232 H N N 137 
CLR H241 H N N 138 
CLR H242 H N N 139 
CLR H25  H N N 140 
CLR H261 H N N 141 
CLR H262 H N N 142 
CLR H263 H N N 143 
CLR H271 H N N 144 
CLR H272 H N N 145 
CLR H273 H N N 146 
CLR H1   H N N 147 
CYS N    N N N 148 
CYS CA   C N R 149 
CYS C    C N N 150 
CYS O    O N N 151 
CYS CB   C N N 152 
CYS SG   S N N 153 
CYS OXT  O N N 154 
CYS H    H N N 155 
CYS H2   H N N 156 
CYS HA   H N N 157 
CYS HB2  H N N 158 
CYS HB3  H N N 159 
CYS HG   H N N 160 
CYS HXT  H N N 161 
GLN N    N N N 162 
GLN CA   C N S 163 
GLN C    C N N 164 
GLN O    O N N 165 
GLN CB   C N N 166 
GLN CG   C N N 167 
GLN CD   C N N 168 
GLN OE1  O N N 169 
GLN NE2  N N N 170 
GLN OXT  O N N 171 
GLN H    H N N 172 
GLN H2   H N N 173 
GLN HA   H N N 174 
GLN HB2  H N N 175 
GLN HB3  H N N 176 
GLN HG2  H N N 177 
GLN HG3  H N N 178 
GLN HE21 H N N 179 
GLN HE22 H N N 180 
GLN HXT  H N N 181 
GLU N    N N N 182 
GLU CA   C N S 183 
GLU C    C N N 184 
GLU O    O N N 185 
GLU CB   C N N 186 
GLU CG   C N N 187 
GLU CD   C N N 188 
GLU OE1  O N N 189 
GLU OE2  O N N 190 
GLU OXT  O N N 191 
GLU H    H N N 192 
GLU H2   H N N 193 
GLU HA   H N N 194 
GLU HB2  H N N 195 
GLU HB3  H N N 196 
GLU HG2  H N N 197 
GLU HG3  H N N 198 
GLU HE2  H N N 199 
GLU HXT  H N N 200 
GLY N    N N N 201 
GLY CA   C N N 202 
GLY C    C N N 203 
GLY O    O N N 204 
GLY OXT  O N N 205 
GLY H    H N N 206 
GLY H2   H N N 207 
GLY HA2  H N N 208 
GLY HA3  H N N 209 
GLY HXT  H N N 210 
HIS N    N N N 211 
HIS CA   C N S 212 
HIS C    C N N 213 
HIS O    O N N 214 
HIS CB   C N N 215 
HIS CG   C Y N 216 
HIS ND1  N Y N 217 
HIS CD2  C Y N 218 
HIS CE1  C Y N 219 
HIS NE2  N Y N 220 
HIS OXT  O N N 221 
HIS H    H N N 222 
HIS H2   H N N 223 
HIS HA   H N N 224 
HIS HB2  H N N 225 
HIS HB3  H N N 226 
HIS HD1  H N N 227 
HIS HD2  H N N 228 
HIS HE1  H N N 229 
HIS HE2  H N N 230 
HIS HXT  H N N 231 
ILE N    N N N 232 
ILE CA   C N S 233 
ILE C    C N N 234 
ILE O    O N N 235 
ILE CB   C N S 236 
ILE CG1  C N N 237 
ILE CG2  C N N 238 
ILE CD1  C N N 239 
ILE OXT  O N N 240 
ILE H    H N N 241 
ILE H2   H N N 242 
ILE HA   H N N 243 
ILE HB   H N N 244 
ILE HG12 H N N 245 
ILE HG13 H N N 246 
ILE HG21 H N N 247 
ILE HG22 H N N 248 
ILE HG23 H N N 249 
ILE HD11 H N N 250 
ILE HD12 H N N 251 
ILE HD13 H N N 252 
ILE HXT  H N N 253 
LEU N    N N N 254 
LEU CA   C N S 255 
LEU C    C N N 256 
LEU O    O N N 257 
LEU CB   C N N 258 
LEU CG   C N N 259 
LEU CD1  C N N 260 
LEU CD2  C N N 261 
LEU OXT  O N N 262 
LEU H    H N N 263 
LEU H2   H N N 264 
LEU HA   H N N 265 
LEU HB2  H N N 266 
LEU HB3  H N N 267 
LEU HG   H N N 268 
LEU HD11 H N N 269 
LEU HD12 H N N 270 
LEU HD13 H N N 271 
LEU HD21 H N N 272 
LEU HD22 H N N 273 
LEU HD23 H N N 274 
LEU HXT  H N N 275 
LYS N    N N N 276 
LYS CA   C N S 277 
LYS C    C N N 278 
LYS O    O N N 279 
LYS CB   C N N 280 
LYS CG   C N N 281 
LYS CD   C N N 282 
LYS CE   C N N 283 
LYS NZ   N N N 284 
LYS OXT  O N N 285 
LYS H    H N N 286 
LYS H2   H N N 287 
LYS HA   H N N 288 
LYS HB2  H N N 289 
LYS HB3  H N N 290 
LYS HG2  H N N 291 
LYS HG3  H N N 292 
LYS HD2  H N N 293 
LYS HD3  H N N 294 
LYS HE2  H N N 295 
LYS HE3  H N N 296 
LYS HZ1  H N N 297 
LYS HZ2  H N N 298 
LYS HZ3  H N N 299 
LYS HXT  H N N 300 
MET N    N N N 301 
MET CA   C N S 302 
MET C    C N N 303 
MET O    O N N 304 
MET CB   C N N 305 
MET CG   C N N 306 
MET SD   S N N 307 
MET CE   C N N 308 
MET OXT  O N N 309 
MET H    H N N 310 
MET H2   H N N 311 
MET HA   H N N 312 
MET HB2  H N N 313 
MET HB3  H N N 314 
MET HG2  H N N 315 
MET HG3  H N N 316 
MET HE1  H N N 317 
MET HE2  H N N 318 
MET HE3  H N N 319 
MET HXT  H N N 320 
PHE N    N N N 321 
PHE CA   C N S 322 
PHE C    C N N 323 
PHE O    O N N 324 
PHE CB   C N N 325 
PHE CG   C Y N 326 
PHE CD1  C Y N 327 
PHE CD2  C Y N 328 
PHE CE1  C Y N 329 
PHE CE2  C Y N 330 
PHE CZ   C Y N 331 
PHE OXT  O N N 332 
PHE H    H N N 333 
PHE H2   H N N 334 
PHE HA   H N N 335 
PHE HB2  H N N 336 
PHE HB3  H N N 337 
PHE HD1  H N N 338 
PHE HD2  H N N 339 
PHE HE1  H N N 340 
PHE HE2  H N N 341 
PHE HZ   H N N 342 
PHE HXT  H N N 343 
PRO N    N N N 344 
PRO CA   C N S 345 
PRO C    C N N 346 
PRO O    O N N 347 
PRO CB   C N N 348 
PRO CG   C N N 349 
PRO CD   C N N 350 
PRO OXT  O N N 351 
PRO H    H N N 352 
PRO HA   H N N 353 
PRO HB2  H N N 354 
PRO HB3  H N N 355 
PRO HG2  H N N 356 
PRO HG3  H N N 357 
PRO HD2  H N N 358 
PRO HD3  H N N 359 
PRO HXT  H N N 360 
SER N    N N N 361 
SER CA   C N S 362 
SER C    C N N 363 
SER O    O N N 364 
SER CB   C N N 365 
SER OG   O N N 366 
SER OXT  O N N 367 
SER H    H N N 368 
SER H2   H N N 369 
SER HA   H N N 370 
SER HB2  H N N 371 
SER HB3  H N N 372 
SER HG   H N N 373 
SER HXT  H N N 374 
THR N    N N N 375 
THR CA   C N S 376 
THR C    C N N 377 
THR O    O N N 378 
THR CB   C N R 379 
THR OG1  O N N 380 
THR CG2  C N N 381 
THR OXT  O N N 382 
THR H    H N N 383 
THR H2   H N N 384 
THR HA   H N N 385 
THR HB   H N N 386 
THR HG1  H N N 387 
THR HG21 H N N 388 
THR HG22 H N N 389 
THR HG23 H N N 390 
THR HXT  H N N 391 
TRP N    N N N 392 
TRP CA   C N S 393 
TRP C    C N N 394 
TRP O    O N N 395 
TRP CB   C N N 396 
TRP CG   C Y N 397 
TRP CD1  C Y N 398 
TRP CD2  C Y N 399 
TRP NE1  N Y N 400 
TRP CE2  C Y N 401 
TRP CE3  C Y N 402 
TRP CZ2  C Y N 403 
TRP CZ3  C Y N 404 
TRP CH2  C Y N 405 
TRP OXT  O N N 406 
TRP H    H N N 407 
TRP H2   H N N 408 
TRP HA   H N N 409 
TRP HB2  H N N 410 
TRP HB3  H N N 411 
TRP HD1  H N N 412 
TRP HE1  H N N 413 
TRP HE3  H N N 414 
TRP HZ2  H N N 415 
TRP HZ3  H N N 416 
TRP HH2  H N N 417 
TRP HXT  H N N 418 
TYR N    N N N 419 
TYR CA   C N S 420 
TYR C    C N N 421 
TYR O    O N N 422 
TYR CB   C N N 423 
TYR CG   C Y N 424 
TYR CD1  C Y N 425 
TYR CD2  C Y N 426 
TYR CE1  C Y N 427 
TYR CE2  C Y N 428 
TYR CZ   C Y N 429 
TYR OH   O N N 430 
TYR OXT  O N N 431 
TYR H    H N N 432 
TYR H2   H N N 433 
TYR HA   H N N 434 
TYR HB2  H N N 435 
TYR HB3  H N N 436 
TYR HD1  H N N 437 
TYR HD2  H N N 438 
TYR HE1  H N N 439 
TYR HE2  H N N 440 
TYR HH   H N N 441 
TYR HXT  H N N 442 
VAL N    N N N 443 
VAL CA   C N S 444 
VAL C    C N N 445 
VAL O    O N N 446 
VAL CB   C N N 447 
VAL CG1  C N N 448 
VAL CG2  C N N 449 
VAL OXT  O N N 450 
VAL H    H N N 451 
VAL H2   H N N 452 
VAL HA   H N N 453 
VAL HB   H N N 454 
VAL HG11 H N N 455 
VAL HG12 H N N 456 
VAL HG13 H N N 457 
VAL HG21 H N N 458 
VAL HG22 H N N 459 
VAL HG23 H N N 460 
VAL HXT  H N N 461 
VH6 C10  C N N 462 
VH6 C13  C N N 463 
VH6 C15  C N N 464 
VH6 C17  C Y N 465 
VH6 C20  C Y N 466 
VH6 C21  C Y N 467 
VH6 C22  C N N 468 
VH6 C24  C N N 469 
VH6 C26  C N N 470 
VH6 C28  C N N 471 
VH6 C02  C N N 472 
VH6 C03  C N N 473 
VH6 C05  C N N 474 
VH6 C06  C N N 475 
VH6 C07  C N N 476 
VH6 C09  C N N 477 
VH6 C12  C N N 478 
VH6 C14  C N N 479 
VH6 C16  C Y N 480 
VH6 C18  C Y N 481 
VH6 C19  C Y N 482 
VH6 C25  C N N 483 
VH6 C29  C N N 484 
VH6 C31  C N N 485 
VH6 C32  C N N 486 
VH6 C33  C N N 487 
VH6 C35  C N N 488 
VH6 C36  C N N 489 
VH6 N01  N N N 490 
VH6 N04  N N N 491 
VH6 N08  N N N 492 
VH6 N11  N N N 493 
VH6 N23  N N N 494 
VH6 N27  N N N 495 
VH6 N30  N N N 496 
VH6 N34  N N N 497 
VH6 H102 H N N 498 
VH6 H101 H N N 499 
VH6 H132 H N N 500 
VH6 H131 H N N 501 
VH6 H151 H N N 502 
VH6 H152 H N N 503 
VH6 H171 H N N 504 
VH6 H201 H N N 505 
VH6 H211 H N N 506 
VH6 H221 H N N 507 
VH6 H222 H N N 508 
VH6 H241 H N N 509 
VH6 H242 H N N 510 
VH6 H262 H N N 511 
VH6 H261 H N N 512 
VH6 H281 H N N 513 
VH6 H282 H N N 514 
VH6 H022 H N N 515 
VH6 H021 H N N 516 
VH6 H032 H N N 517 
VH6 H031 H N N 518 
VH6 H052 H N N 519 
VH6 H051 H N N 520 
VH6 H061 H N N 521 
VH6 H062 H N N 522 
VH6 H072 H N N 523 
VH6 H071 H N N 524 
VH6 H091 H N N 525 
VH6 H092 H N N 526 
VH6 H122 H N N 527 
VH6 H121 H N N 528 
VH6 H141 H N N 529 
VH6 H142 H N N 530 
VH6 H181 H N N 531 
VH6 H252 H N N 532 
VH6 H251 H N N 533 
VH6 H292 H N N 534 
VH6 H291 H N N 535 
VH6 H312 H N N 536 
VH6 H311 H N N 537 
VH6 H321 H N N 538 
VH6 H322 H N N 539 
VH6 H332 H N N 540 
VH6 H331 H N N 541 
VH6 H352 H N N 542 
VH6 H351 H N N 543 
VH6 H361 H N N 544 
VH6 H362 H N N 545 
VH6 H011 H N N 546 
VH6 H2   H N N 547 
VH6 H111 H N N 548 
VH6 H6   H N N 549 
VH6 H301 H N N 550 
VH6 H8   H N N 551 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CLR C1  C2   sing N N 70  
CLR C1  C10  sing N N 71  
CLR C1  H11  sing N N 72  
CLR C1  H12  sing N N 73  
CLR C2  C3   sing N N 74  
CLR C2  H21  sing N N 75  
CLR C2  H22  sing N N 76  
CLR C3  C4   sing N N 77  
CLR C3  O1   sing N N 78  
CLR C3  H3   sing N N 79  
CLR C4  C5   sing N N 80  
CLR C4  H41  sing N N 81  
CLR C4  H42  sing N N 82  
CLR C5  C6   doub N N 83  
CLR C5  C10  sing N N 84  
CLR C6  C7   sing N N 85  
CLR C6  H6   sing N N 86  
CLR C7  C8   sing N N 87  
CLR C7  H71  sing N N 88  
CLR C7  H72  sing N N 89  
CLR C8  C9   sing N N 90  
CLR C8  C14  sing N N 91  
CLR C8  H8   sing N N 92  
CLR C9  C10  sing N N 93  
CLR C9  C11  sing N N 94  
CLR C9  H9   sing N N 95  
CLR C10 C19  sing N N 96  
CLR C11 C12  sing N N 97  
CLR C11 H111 sing N N 98  
CLR C11 H112 sing N N 99  
CLR C12 C13  sing N N 100 
CLR C12 H121 sing N N 101 
CLR C12 H122 sing N N 102 
CLR C13 C14  sing N N 103 
CLR C13 C17  sing N N 104 
CLR C13 C18  sing N N 105 
CLR C14 C15  sing N N 106 
CLR C14 H14  sing N N 107 
CLR C15 C16  sing N N 108 
CLR C15 H151 sing N N 109 
CLR C15 H152 sing N N 110 
CLR C16 C17  sing N N 111 
CLR C16 H161 sing N N 112 
CLR C16 H162 sing N N 113 
CLR C17 C20  sing N N 114 
CLR C17 H17  sing N N 115 
CLR C18 H181 sing N N 116 
CLR C18 H182 sing N N 117 
CLR C18 H183 sing N N 118 
CLR C19 H191 sing N N 119 
CLR C19 H192 sing N N 120 
CLR C19 H193 sing N N 121 
CLR C20 C21  sing N N 122 
CLR C20 C22  sing N N 123 
CLR C20 H20  sing N N 124 
CLR C21 H211 sing N N 125 
CLR C21 H212 sing N N 126 
CLR C21 H213 sing N N 127 
CLR C22 C23  sing N N 128 
CLR C22 H221 sing N N 129 
CLR C22 H222 sing N N 130 
CLR C23 C24  sing N N 131 
CLR C23 H231 sing N N 132 
CLR C23 H232 sing N N 133 
CLR C24 C25  sing N N 134 
CLR C24 H241 sing N N 135 
CLR C24 H242 sing N N 136 
CLR C25 C26  sing N N 137 
CLR C25 C27  sing N N 138 
CLR C25 H25  sing N N 139 
CLR C26 H261 sing N N 140 
CLR C26 H262 sing N N 141 
CLR C26 H263 sing N N 142 
CLR C27 H271 sing N N 143 
CLR C27 H272 sing N N 144 
CLR C27 H273 sing N N 145 
CLR O1  H1   sing N N 146 
CYS N   CA   sing N N 147 
CYS N   H    sing N N 148 
CYS N   H2   sing N N 149 
CYS CA  C    sing N N 150 
CYS CA  CB   sing N N 151 
CYS CA  HA   sing N N 152 
CYS C   O    doub N N 153 
CYS C   OXT  sing N N 154 
CYS CB  SG   sing N N 155 
CYS CB  HB2  sing N N 156 
CYS CB  HB3  sing N N 157 
CYS SG  HG   sing N N 158 
CYS OXT HXT  sing N N 159 
GLN N   CA   sing N N 160 
GLN N   H    sing N N 161 
GLN N   H2   sing N N 162 
GLN CA  C    sing N N 163 
GLN CA  CB   sing N N 164 
GLN CA  HA   sing N N 165 
GLN C   O    doub N N 166 
GLN C   OXT  sing N N 167 
GLN CB  CG   sing N N 168 
GLN CB  HB2  sing N N 169 
GLN CB  HB3  sing N N 170 
GLN CG  CD   sing N N 171 
GLN CG  HG2  sing N N 172 
GLN CG  HG3  sing N N 173 
GLN CD  OE1  doub N N 174 
GLN CD  NE2  sing N N 175 
GLN NE2 HE21 sing N N 176 
GLN NE2 HE22 sing N N 177 
GLN OXT HXT  sing N N 178 
GLU N   CA   sing N N 179 
GLU N   H    sing N N 180 
GLU N   H2   sing N N 181 
GLU CA  C    sing N N 182 
GLU CA  CB   sing N N 183 
GLU CA  HA   sing N N 184 
GLU C   O    doub N N 185 
GLU C   OXT  sing N N 186 
GLU CB  CG   sing N N 187 
GLU CB  HB2  sing N N 188 
GLU CB  HB3  sing N N 189 
GLU CG  CD   sing N N 190 
GLU CG  HG2  sing N N 191 
GLU CG  HG3  sing N N 192 
GLU CD  OE1  doub N N 193 
GLU CD  OE2  sing N N 194 
GLU OE2 HE2  sing N N 195 
GLU OXT HXT  sing N N 196 
GLY N   CA   sing N N 197 
GLY N   H    sing N N 198 
GLY N   H2   sing N N 199 
GLY CA  C    sing N N 200 
GLY CA  HA2  sing N N 201 
GLY CA  HA3  sing N N 202 
GLY C   O    doub N N 203 
GLY C   OXT  sing N N 204 
GLY OXT HXT  sing N N 205 
HIS N   CA   sing N N 206 
HIS N   H    sing N N 207 
HIS N   H2   sing N N 208 
HIS CA  C    sing N N 209 
HIS CA  CB   sing N N 210 
HIS CA  HA   sing N N 211 
HIS C   O    doub N N 212 
HIS C   OXT  sing N N 213 
HIS CB  CG   sing N N 214 
HIS CB  HB2  sing N N 215 
HIS CB  HB3  sing N N 216 
HIS CG  ND1  sing Y N 217 
HIS CG  CD2  doub Y N 218 
HIS ND1 CE1  doub Y N 219 
HIS ND1 HD1  sing N N 220 
HIS CD2 NE2  sing Y N 221 
HIS CD2 HD2  sing N N 222 
HIS CE1 NE2  sing Y N 223 
HIS CE1 HE1  sing N N 224 
HIS NE2 HE2  sing N N 225 
HIS OXT HXT  sing N N 226 
ILE N   CA   sing N N 227 
ILE N   H    sing N N 228 
ILE N   H2   sing N N 229 
ILE CA  C    sing N N 230 
ILE CA  CB   sing N N 231 
ILE CA  HA   sing N N 232 
ILE C   O    doub N N 233 
ILE C   OXT  sing N N 234 
ILE CB  CG1  sing N N 235 
ILE CB  CG2  sing N N 236 
ILE CB  HB   sing N N 237 
ILE CG1 CD1  sing N N 238 
ILE CG1 HG12 sing N N 239 
ILE CG1 HG13 sing N N 240 
ILE CG2 HG21 sing N N 241 
ILE CG2 HG22 sing N N 242 
ILE CG2 HG23 sing N N 243 
ILE CD1 HD11 sing N N 244 
ILE CD1 HD12 sing N N 245 
ILE CD1 HD13 sing N N 246 
ILE OXT HXT  sing N N 247 
LEU N   CA   sing N N 248 
LEU N   H    sing N N 249 
LEU N   H2   sing N N 250 
LEU CA  C    sing N N 251 
LEU CA  CB   sing N N 252 
LEU CA  HA   sing N N 253 
LEU C   O    doub N N 254 
LEU C   OXT  sing N N 255 
LEU CB  CG   sing N N 256 
LEU CB  HB2  sing N N 257 
LEU CB  HB3  sing N N 258 
LEU CG  CD1  sing N N 259 
LEU CG  CD2  sing N N 260 
LEU CG  HG   sing N N 261 
LEU CD1 HD11 sing N N 262 
LEU CD1 HD12 sing N N 263 
LEU CD1 HD13 sing N N 264 
LEU CD2 HD21 sing N N 265 
LEU CD2 HD22 sing N N 266 
LEU CD2 HD23 sing N N 267 
LEU OXT HXT  sing N N 268 
LYS N   CA   sing N N 269 
LYS N   H    sing N N 270 
LYS N   H2   sing N N 271 
LYS CA  C    sing N N 272 
LYS CA  CB   sing N N 273 
LYS CA  HA   sing N N 274 
LYS C   O    doub N N 275 
LYS C   OXT  sing N N 276 
LYS CB  CG   sing N N 277 
LYS CB  HB2  sing N N 278 
LYS CB  HB3  sing N N 279 
LYS CG  CD   sing N N 280 
LYS CG  HG2  sing N N 281 
LYS CG  HG3  sing N N 282 
LYS CD  CE   sing N N 283 
LYS CD  HD2  sing N N 284 
LYS CD  HD3  sing N N 285 
LYS CE  NZ   sing N N 286 
LYS CE  HE2  sing N N 287 
LYS CE  HE3  sing N N 288 
LYS NZ  HZ1  sing N N 289 
LYS NZ  HZ2  sing N N 290 
LYS NZ  HZ3  sing N N 291 
LYS OXT HXT  sing N N 292 
MET N   CA   sing N N 293 
MET N   H    sing N N 294 
MET N   H2   sing N N 295 
MET CA  C    sing N N 296 
MET CA  CB   sing N N 297 
MET CA  HA   sing N N 298 
MET C   O    doub N N 299 
MET C   OXT  sing N N 300 
MET CB  CG   sing N N 301 
MET CB  HB2  sing N N 302 
MET CB  HB3  sing N N 303 
MET CG  SD   sing N N 304 
MET CG  HG2  sing N N 305 
MET CG  HG3  sing N N 306 
MET SD  CE   sing N N 307 
MET CE  HE1  sing N N 308 
MET CE  HE2  sing N N 309 
MET CE  HE3  sing N N 310 
MET OXT HXT  sing N N 311 
PHE N   CA   sing N N 312 
PHE N   H    sing N N 313 
PHE N   H2   sing N N 314 
PHE CA  C    sing N N 315 
PHE CA  CB   sing N N 316 
PHE CA  HA   sing N N 317 
PHE C   O    doub N N 318 
PHE C   OXT  sing N N 319 
PHE CB  CG   sing N N 320 
PHE CB  HB2  sing N N 321 
PHE CB  HB3  sing N N 322 
PHE CG  CD1  doub Y N 323 
PHE CG  CD2  sing Y N 324 
PHE CD1 CE1  sing Y N 325 
PHE CD1 HD1  sing N N 326 
PHE CD2 CE2  doub Y N 327 
PHE CD2 HD2  sing N N 328 
PHE CE1 CZ   doub Y N 329 
PHE CE1 HE1  sing N N 330 
PHE CE2 CZ   sing Y N 331 
PHE CE2 HE2  sing N N 332 
PHE CZ  HZ   sing N N 333 
PHE OXT HXT  sing N N 334 
PRO N   CA   sing N N 335 
PRO N   CD   sing N N 336 
PRO N   H    sing N N 337 
PRO CA  C    sing N N 338 
PRO CA  CB   sing N N 339 
PRO CA  HA   sing N N 340 
PRO C   O    doub N N 341 
PRO C   OXT  sing N N 342 
PRO CB  CG   sing N N 343 
PRO CB  HB2  sing N N 344 
PRO CB  HB3  sing N N 345 
PRO CG  CD   sing N N 346 
PRO CG  HG2  sing N N 347 
PRO CG  HG3  sing N N 348 
PRO CD  HD2  sing N N 349 
PRO CD  HD3  sing N N 350 
PRO OXT HXT  sing N N 351 
SER N   CA   sing N N 352 
SER N   H    sing N N 353 
SER N   H2   sing N N 354 
SER CA  C    sing N N 355 
SER CA  CB   sing N N 356 
SER CA  HA   sing N N 357 
SER C   O    doub N N 358 
SER C   OXT  sing N N 359 
SER CB  OG   sing N N 360 
SER CB  HB2  sing N N 361 
SER CB  HB3  sing N N 362 
SER OG  HG   sing N N 363 
SER OXT HXT  sing N N 364 
THR N   CA   sing N N 365 
THR N   H    sing N N 366 
THR N   H2   sing N N 367 
THR CA  C    sing N N 368 
THR CA  CB   sing N N 369 
THR CA  HA   sing N N 370 
THR C   O    doub N N 371 
THR C   OXT  sing N N 372 
THR CB  OG1  sing N N 373 
THR CB  CG2  sing N N 374 
THR CB  HB   sing N N 375 
THR OG1 HG1  sing N N 376 
THR CG2 HG21 sing N N 377 
THR CG2 HG22 sing N N 378 
THR CG2 HG23 sing N N 379 
THR OXT HXT  sing N N 380 
TRP N   CA   sing N N 381 
TRP N   H    sing N N 382 
TRP N   H2   sing N N 383 
TRP CA  C    sing N N 384 
TRP CA  CB   sing N N 385 
TRP CA  HA   sing N N 386 
TRP C   O    doub N N 387 
TRP C   OXT  sing N N 388 
TRP CB  CG   sing N N 389 
TRP CB  HB2  sing N N 390 
TRP CB  HB3  sing N N 391 
TRP CG  CD1  doub Y N 392 
TRP CG  CD2  sing Y N 393 
TRP CD1 NE1  sing Y N 394 
TRP CD1 HD1  sing N N 395 
TRP CD2 CE2  doub Y N 396 
TRP CD2 CE3  sing Y N 397 
TRP NE1 CE2  sing Y N 398 
TRP NE1 HE1  sing N N 399 
TRP CE2 CZ2  sing Y N 400 
TRP CE3 CZ3  doub Y N 401 
TRP CE3 HE3  sing N N 402 
TRP CZ2 CH2  doub Y N 403 
TRP CZ2 HZ2  sing N N 404 
TRP CZ3 CH2  sing Y N 405 
TRP CZ3 HZ3  sing N N 406 
TRP CH2 HH2  sing N N 407 
TRP OXT HXT  sing N N 408 
TYR N   CA   sing N N 409 
TYR N   H    sing N N 410 
TYR N   H2   sing N N 411 
TYR CA  C    sing N N 412 
TYR CA  CB   sing N N 413 
TYR CA  HA   sing N N 414 
TYR C   O    doub N N 415 
TYR C   OXT  sing N N 416 
TYR CB  CG   sing N N 417 
TYR CB  HB2  sing N N 418 
TYR CB  HB3  sing N N 419 
TYR CG  CD1  doub Y N 420 
TYR CG  CD2  sing Y N 421 
TYR CD1 CE1  sing Y N 422 
TYR CD1 HD1  sing N N 423 
TYR CD2 CE2  doub Y N 424 
TYR CD2 HD2  sing N N 425 
TYR CE1 CZ   doub Y N 426 
TYR CE1 HE1  sing N N 427 
TYR CE2 CZ   sing Y N 428 
TYR CE2 HE2  sing N N 429 
TYR CZ  OH   sing N N 430 
TYR OH  HH   sing N N 431 
TYR OXT HXT  sing N N 432 
VAL N   CA   sing N N 433 
VAL N   H    sing N N 434 
VAL N   H2   sing N N 435 
VAL CA  C    sing N N 436 
VAL CA  CB   sing N N 437 
VAL CA  HA   sing N N 438 
VAL C   O    doub N N 439 
VAL C   OXT  sing N N 440 
VAL CB  CG1  sing N N 441 
VAL CB  CG2  sing N N 442 
VAL CB  HB   sing N N 443 
VAL CG1 HG11 sing N N 444 
VAL CG1 HG12 sing N N 445 
VAL CG1 HG13 sing N N 446 
VAL CG2 HG21 sing N N 447 
VAL CG2 HG22 sing N N 448 
VAL CG2 HG23 sing N N 449 
VAL OXT HXT  sing N N 450 
VH6 C02 N01  sing N N 451 
VH6 C03 C02  sing N N 452 
VH6 N04 C03  sing N N 453 
VH6 C05 N04  sing N N 454 
VH6 C06 C05  sing N N 455 
VH6 C07 C06  sing N N 456 
VH6 N08 C07  sing N N 457 
VH6 C10 C09  sing N N 458 
VH6 N11 C10  sing N N 459 
VH6 C12 N11  sing N N 460 
VH6 C13 C12  sing N N 461 
VH6 C14 C13  sing N N 462 
VH6 C09 N08  sing N N 463 
VH6 C15 N08  sing N N 464 
VH6 C16 C15  sing N N 465 
VH6 C17 C16  doub Y N 466 
VH6 C18 C17  sing Y N 467 
VH6 C19 C18  doub Y N 468 
VH6 C21 C20  doub Y N 469 
VH6 C20 C19  sing Y N 470 
VH6 C22 C19  sing N N 471 
VH6 N23 C22  sing N N 472 
VH6 C24 N23  sing N N 473 
VH6 C25 C24  sing N N 474 
VH6 C26 C25  sing N N 475 
VH6 N27 C26  sing N N 476 
VH6 C28 N27  sing N N 477 
VH6 C29 C28  sing N N 478 
VH6 N30 C29  sing N N 479 
VH6 C31 N30  sing N N 480 
VH6 C32 C31  sing N N 481 
VH6 C33 C32  sing N N 482 
VH6 N34 C33  sing N N 483 
VH6 C35 N34  sing N N 484 
VH6 C36 C35  sing N N 485 
VH6 N01 C14  sing N N 486 
VH6 C16 C21  sing Y N 487 
VH6 N23 C36  sing N N 488 
VH6 C10 H102 sing N N 489 
VH6 C10 H101 sing N N 490 
VH6 C13 H132 sing N N 491 
VH6 C13 H131 sing N N 492 
VH6 C15 H151 sing N N 493 
VH6 C15 H152 sing N N 494 
VH6 C17 H171 sing N N 495 
VH6 C20 H201 sing N N 496 
VH6 C21 H211 sing N N 497 
VH6 C22 H221 sing N N 498 
VH6 C22 H222 sing N N 499 
VH6 C24 H241 sing N N 500 
VH6 C24 H242 sing N N 501 
VH6 C26 H262 sing N N 502 
VH6 C26 H261 sing N N 503 
VH6 C28 H281 sing N N 504 
VH6 C28 H282 sing N N 505 
VH6 C02 H022 sing N N 506 
VH6 C02 H021 sing N N 507 
VH6 C03 H032 sing N N 508 
VH6 C03 H031 sing N N 509 
VH6 C05 H052 sing N N 510 
VH6 C05 H051 sing N N 511 
VH6 C06 H061 sing N N 512 
VH6 C06 H062 sing N N 513 
VH6 C07 H072 sing N N 514 
VH6 C07 H071 sing N N 515 
VH6 C09 H091 sing N N 516 
VH6 C09 H092 sing N N 517 
VH6 C12 H122 sing N N 518 
VH6 C12 H121 sing N N 519 
VH6 C14 H141 sing N N 520 
VH6 C14 H142 sing N N 521 
VH6 C18 H181 sing N N 522 
VH6 C25 H252 sing N N 523 
VH6 C25 H251 sing N N 524 
VH6 C29 H292 sing N N 525 
VH6 C29 H291 sing N N 526 
VH6 C31 H312 sing N N 527 
VH6 C31 H311 sing N N 528 
VH6 C32 H321 sing N N 529 
VH6 C32 H322 sing N N 530 
VH6 C33 H332 sing N N 531 
VH6 C33 H331 sing N N 532 
VH6 C35 H352 sing N N 533 
VH6 C35 H351 sing N N 534 
VH6 C36 H361 sing N N 535 
VH6 C36 H362 sing N N 536 
VH6 N01 H011 sing N N 537 
VH6 N04 H2   sing N N 538 
VH6 N11 H111 sing N N 539 
VH6 N27 H6   sing N N 540 
VH6 N30 H301 sing N N 541 
VH6 N34 H8   sing N N 542 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-05-30 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8ZPN 
_em_admin.last_update        2025-04-02 
_em_admin.map_release_date   2025-02-26 
_em_admin.title              'Cryo-EM strucutre of CXCR4 complexed with antagonist AMD3100' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         53.5 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
_em_imaging_optics.chr_aberration_corrector   ? 
_em_imaging_optics.energyfilter_lower         ? 
_em_imaging_optics.energyfilter_slit_width    20 
_em_imaging_optics.energyfilter_name          'GIF Bioquantum' 
_em_imaging_optics.energyfilter_upper         ? 
_em_imaging_optics.id                         1 
_em_imaging_optics.imaging_id                 1 
_em_imaging_optics.phase_plate                ? 
_em_imaging_optics.sph_aberration_corrector   ? 
_em_imaging_optics.details                    ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Other government' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           32100963 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8ZPN 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA A 1 172 ? 115.602 152.130 115.499 1.00 95.66  ? 34  ALA R N   1 
ATOM   2    C CA  . ALA A 1 172 ? 116.711 151.457 116.163 1.00 96.58  ? 34  ALA R CA  1 
ATOM   3    C C   . ALA A 1 172 ? 117.982 152.295 116.085 1.00 97.11  ? 34  ALA R C   1 
ATOM   4    O O   . ALA A 1 172 ? 119.088 151.777 116.247 1.00 99.28  ? 34  ALA R O   1 
ATOM   5    C CB  . ALA A 1 172 ? 116.942 150.085 115.552 1.00 95.82  ? 34  ALA R CB  1 
ATOM   6    N N   . ASN A 1 173 ? 117.814 153.596 115.834 1.00 96.25  ? 35  ASN R N   1 
ATOM   7    C CA  . ASN A 1 173 ? 118.966 154.487 115.745 1.00 95.53  ? 35  ASN R CA  1 
ATOM   8    C C   . ASN A 1 173 ? 119.711 154.561 117.072 1.00 92.75  ? 35  ASN R C   1 
ATOM   9    O O   . ASN A 1 173 ? 120.946 154.644 117.096 1.00 92.41  ? 35  ASN R O   1 
ATOM   10   C CB  . ASN A 1 173 ? 118.522 155.881 115.303 1.00 95.76  ? 35  ASN R CB  1 
ATOM   11   C CG  . ASN A 1 173 ? 117.880 155.880 113.929 1.00 95.29  ? 35  ASN R CG  1 
ATOM   12   O OD1 . ASN A 1 173 ? 116.684 156.134 113.788 1.00 95.35  ? 35  ASN R OD1 1 
ATOM   13   N ND2 . ASN A 1 173 ? 118.677 155.594 112.905 1.00 93.42  ? 35  ASN R ND2 1 
ATOM   14   N N   . PHE A 1 174 ? 118.978 154.534 118.186 1.00 94.93  ? 36  PHE R N   1 
ATOM   15   C CA  . PHE A 1 174 ? 119.618 154.602 119.495 1.00 97.09  ? 36  PHE R CA  1 
ATOM   16   C C   . PHE A 1 174 ? 120.571 153.432 119.698 1.00 96.04  ? 36  PHE R C   1 
ATOM   17   O O   . PHE A 1 174 ? 121.722 153.618 120.105 1.00 98.22  ? 36  PHE R O   1 
ATOM   18   C CB  . PHE A 1 174 ? 118.556 154.634 120.596 1.00 98.77  ? 36  PHE R CB  1 
ATOM   19   C CG  . PHE A 1 174 ? 117.786 155.923 120.660 1.00 102.32 ? 36  PHE R CG  1 
ATOM   20   C CD1 . PHE A 1 174 ? 118.344 157.104 120.198 1.00 100.61 ? 36  PHE R CD1 1 
ATOM   21   C CD2 . PHE A 1 174 ? 116.503 155.954 121.183 1.00 99.53  ? 36  PHE R CD2 1 
ATOM   22   C CE1 . PHE A 1 174 ? 117.636 158.292 120.256 1.00 96.55  ? 36  PHE R CE1 1 
ATOM   23   C CE2 . PHE A 1 174 ? 115.791 157.138 121.244 1.00 98.40  ? 36  PHE R CE2 1 
ATOM   24   C CZ  . PHE A 1 174 ? 116.358 158.308 120.779 1.00 96.00  ? 36  PHE R CZ  1 
ATOM   25   N N   . ASN A 1 175 ? 120.116 152.215 119.391 1.00 81.75  ? 37  ASN R N   1 
ATOM   26   C CA  . ASN A 1 175 ? 120.982 151.047 119.523 1.00 81.66  ? 37  ASN R CA  1 
ATOM   27   C C   . ASN A 1 175 ? 122.106 151.072 118.492 1.00 80.70  ? 37  ASN R C   1 
ATOM   28   O O   . ASN A 1 175 ? 123.252 150.714 118.802 1.00 80.98  ? 37  ASN R O   1 
ATOM   29   C CB  . ASN A 1 175 ? 120.154 149.770 119.388 1.00 80.13  ? 37  ASN R CB  1 
ATOM   30   C CG  . ASN A 1 175 ? 120.885 148.543 119.890 1.00 83.01  ? 37  ASN R CG  1 
ATOM   31   O OD1 . ASN A 1 175 ? 121.961 148.646 120.477 1.00 85.96  ? 37  ASN R OD1 1 
ATOM   32   N ND2 . ASN A 1 175 ? 120.302 147.372 119.664 1.00 80.42  ? 37  ASN R ND2 1 
ATOM   33   N N   . LYS A 1 176 ? 121.796 151.503 117.264 1.00 74.64  ? 38  LYS R N   1 
ATOM   34   C CA  . LYS A 1 176 ? 122.797 151.553 116.202 1.00 69.97  ? 38  LYS R CA  1 
ATOM   35   C C   . LYS A 1 176 ? 123.934 152.506 116.542 1.00 72.65  ? 38  LYS R C   1 
ATOM   36   O O   . LYS A 1 176 ? 125.072 152.294 116.108 1.00 74.67  ? 38  LYS R O   1 
ATOM   37   C CB  . LYS A 1 176 ? 122.132 151.965 114.887 1.00 72.32  ? 38  LYS R CB  1 
ATOM   38   C CG  . LYS A 1 176 ? 123.086 152.143 113.716 1.00 73.13  ? 38  LYS R CG  1 
ATOM   39   C CD  . LYS A 1 176 ? 122.339 152.415 112.416 1.00 74.59  ? 38  LYS R CD  1 
ATOM   40   C CE  . LYS A 1 176 ? 121.099 151.541 112.276 1.00 74.56  ? 38  LYS R CE  1 
ATOM   41   N NZ  . LYS A 1 176 ? 121.429 150.089 112.285 1.00 76.68  ? 38  LYS R NZ  1 
ATOM   42   N N   . ILE A 1 177 ? 123.649 153.559 117.301 1.00 74.00  ? 39  ILE R N   1 
ATOM   43   C CA  . ILE A 1 177 ? 124.702 154.472 117.731 1.00 70.61  ? 39  ILE R CA  1 
ATOM   44   C C   . ILE A 1 177 ? 125.339 154.025 119.047 1.00 69.07  ? 39  ILE R C   1 
ATOM   45   O O   . ILE A 1 177 ? 126.528 154.272 119.274 1.00 69.12  ? 39  ILE R O   1 
ATOM   46   C CB  . ILE A 1 177 ? 124.143 155.902 117.835 1.00 67.75  ? 39  ILE R CB  1 
ATOM   47   C CG1 . ILE A 1 177 ? 123.613 156.363 116.477 1.00 69.24  ? 39  ILE R CG1 1 
ATOM   48   C CG2 . ILE A 1 177 ? 125.206 156.873 118.326 1.00 67.59  ? 39  ILE R CG2 1 
ATOM   49   C CD1 . ILE A 1 177 ? 122.825 157.652 116.535 1.00 72.16  ? 39  ILE R CD1 1 
ATOM   50   N N   . PHE A 1 178 ? 124.581 153.347 119.912 1.00 56.52  ? 40  PHE R N   1 
ATOM   51   C CA  . PHE A 1 178 ? 125.099 152.974 121.223 1.00 50.68  ? 40  PHE R CA  1 
ATOM   52   C C   . PHE A 1 178 ? 126.085 151.815 121.139 1.00 54.99  ? 40  PHE R C   1 
ATOM   53   O O   . PHE A 1 178 ? 127.103 151.815 121.840 1.00 63.41  ? 40  PHE R O   1 
ATOM   54   C CB  . PHE A 1 178 ? 123.941 152.625 122.156 1.00 55.68  ? 40  PHE R CB  1 
ATOM   55   C CG  . PHE A 1 178 ? 124.374 152.039 123.465 1.00 56.33  ? 40  PHE R CG  1 
ATOM   56   C CD1 . PHE A 1 178 ? 124.879 152.846 124.466 1.00 62.68  ? 40  PHE R CD1 1 
ATOM   57   C CD2 . PHE A 1 178 ? 124.270 150.679 123.697 1.00 55.02  ? 40  PHE R CD2 1 
ATOM   58   C CE1 . PHE A 1 178 ? 125.276 152.309 125.672 1.00 61.34  ? 40  PHE R CE1 1 
ATOM   59   C CE2 . PHE A 1 178 ? 124.666 150.136 124.900 1.00 56.00  ? 40  PHE R CE2 1 
ATOM   60   C CZ  . PHE A 1 178 ? 125.169 150.953 125.888 1.00 55.73  ? 40  PHE R CZ  1 
ATOM   61   N N   . LEU A 1 179 ? 125.798 150.812 120.308 1.00 52.65  ? 41  LEU R N   1 
ATOM   62   C CA  . LEU A 1 179 ? 126.643 149.617 120.282 1.00 53.03  ? 41  LEU R CA  1 
ATOM   63   C C   . LEU A 1 179 ? 128.087 149.889 119.866 1.00 57.33  ? 41  LEU R C   1 
ATOM   64   O O   . LEU A 1 179 ? 129.005 149.456 120.589 1.00 60.18  ? 41  LEU R O   1 
ATOM   65   C CB  . LEU A 1 179 ? 126.000 148.558 119.380 1.00 53.73  ? 41  LEU R CB  1 
ATOM   66   C CG  . LEU A 1 179 ? 124.974 147.635 120.037 1.00 50.99  ? 41  LEU R CG  1 
ATOM   67   C CD1 . LEU A 1 179 ? 124.706 146.417 119.167 1.00 49.02  ? 41  LEU R CD1 1 
ATOM   68   C CD2 . LEU A 1 179 ? 125.445 147.216 121.413 1.00 52.35  ? 41  LEU R CD2 1 
ATOM   69   N N   . PRO A 1 180 ? 128.371 150.564 118.742 1.00 49.00  ? 42  PRO R N   1 
ATOM   70   C CA  . PRO A 1 180 ? 129.779 150.723 118.337 1.00 47.25  ? 42  PRO R CA  1 
ATOM   71   C C   . PRO A 1 180 ? 130.610 151.523 119.323 1.00 47.79  ? 42  PRO R C   1 
ATOM   72   O O   . PRO A 1 180 ? 131.799 151.232 119.501 1.00 52.28  ? 42  PRO R O   1 
ATOM   73   C CB  . PRO A 1 180 ? 129.686 151.429 116.976 1.00 48.74  ? 42  PRO R CB  1 
ATOM   74   C CG  . PRO A 1 180 ? 128.258 151.409 116.589 1.00 45.62  ? 42  PRO R CG  1 
ATOM   75   C CD  . PRO A 1 180 ? 127.452 151.246 117.816 1.00 49.30  ? 42  PRO R CD  1 
ATOM   76   N N   . THR A 1 181 ? 130.017 152.524 119.974 1.00 40.24  ? 43  THR R N   1 
ATOM   77   C CA  . THR A 1 181 ? 130.775 153.336 120.921 1.00 46.11  ? 43  THR R CA  1 
ATOM   78   C C   . THR A 1 181 ? 131.271 152.491 122.087 1.00 43.79  ? 43  THR R C   1 
ATOM   79   O O   . THR A 1 181 ? 132.438 152.585 122.488 1.00 51.89  ? 43  THR R O   1 
ATOM   80   C CB  . THR A 1 181 ? 129.913 154.495 121.420 1.00 46.85  ? 43  THR R CB  1 
ATOM   81   O OG1 . THR A 1 181 ? 129.438 155.252 120.300 1.00 39.82  ? 43  THR R OG1 1 
ATOM   82   C CG2 . THR A 1 181 ? 130.722 155.406 122.324 1.00 48.56  ? 43  THR R CG2 1 
ATOM   83   N N   . ILE A 1 182 ? 130.400 151.642 122.632 1.00 34.40  ? 44  ILE R N   1 
ATOM   84   C CA  . ILE A 1 182 ? 130.802 150.782 123.738 1.00 42.49  ? 44  ILE R CA  1 
ATOM   85   C C   . ILE A 1 182 ? 131.802 149.734 123.265 1.00 50.80  ? 44  ILE R C   1 
ATOM   86   O O   . ILE A 1 182 ? 132.803 149.462 123.945 1.00 60.82  ? 44  ILE R O   1 
ATOM   87   C CB  . ILE A 1 182 ? 129.565 150.141 124.391 1.00 44.91  ? 44  ILE R CB  1 
ATOM   88   C CG1 . ILE A 1 182 ? 128.674 151.220 125.011 1.00 50.30  ? 44  ILE R CG1 1 
ATOM   89   C CG2 . ILE A 1 182 ? 129.979 149.142 125.452 1.00 42.55  ? 44  ILE R CG2 1 
ATOM   90   C CD1 . ILE A 1 182 ? 129.419 152.205 125.884 1.00 45.89  ? 44  ILE R CD1 1 
ATOM   91   N N   . TYR A 1 183 ? 131.558 149.129 122.097 1.00 45.42  ? 45  TYR R N   1 
ATOM   92   C CA  . TYR A 1 183 ? 132.484 148.137 121.558 1.00 40.25  ? 45  TYR R CA  1 
ATOM   93   C C   . TYR A 1 183 ? 133.856 148.710 121.233 1.00 35.01  ? 45  TYR R C   1 
ATOM   94   O O   . TYR A 1 183 ? 134.827 147.949 121.170 1.00 35.48  ? 45  TYR R O   1 
ATOM   95   C CB  . TYR A 1 183 ? 131.911 147.483 120.296 1.00 46.27  ? 45  TYR R CB  1 
ATOM   96   C CG  . TYR A 1 183 ? 130.706 146.601 120.528 1.00 46.61  ? 45  TYR R CG  1 
ATOM   97   C CD1 . TYR A 1 183 ? 130.567 145.876 121.702 1.00 46.99  ? 45  TYR R CD1 1 
ATOM   98   C CD2 . TYR A 1 183 ? 129.724 146.471 119.560 1.00 45.01  ? 45  TYR R CD2 1 
ATOM   99   C CE1 . TYR A 1 183 ? 129.472 145.063 121.912 1.00 48.12  ? 45  TYR R CE1 1 
ATOM   100  C CE2 . TYR A 1 183 ? 128.628 145.662 119.760 1.00 42.20  ? 45  TYR R CE2 1 
ATOM   101  C CZ  . TYR A 1 183 ? 128.506 144.959 120.937 1.00 46.49  ? 45  TYR R CZ  1 
ATOM   102  O OH  . TYR A 1 183 ? 127.411 144.150 121.138 1.00 57.67  ? 45  TYR R OH  1 
ATOM   103  N N   . SER A 1 184 ? 133.956 150.018 121.009 1.00 33.13  ? 46  SER R N   1 
ATOM   104  C CA  . SER A 1 184 ? 135.241 150.661 120.771 1.00 35.52  ? 46  SER R CA  1 
ATOM   105  C C   . SER A 1 184 ? 135.915 151.107 122.065 1.00 40.53  ? 46  SER R C   1 
ATOM   106  O O   . SER A 1 184 ? 137.137 150.988 122.198 1.00 35.62  ? 46  SER R O   1 
ATOM   107  C CB  . SER A 1 184 ? 135.054 151.857 119.832 1.00 35.86  ? 46  SER R CB  1 
ATOM   108  O OG  . SER A 1 184 ? 134.825 151.425 118.503 1.00 32.69  ? 46  SER R OG  1 
ATOM   109  N N   . ILE A 1 185 ? 135.143 151.609 123.031 1.00 45.78  ? 47  ILE R N   1 
ATOM   110  C CA  . ILE A 1 185 ? 135.723 151.967 124.324 1.00 38.97  ? 47  ILE R CA  1 
ATOM   111  C C   . ILE A 1 185 ? 136.320 150.736 124.989 1.00 37.39  ? 47  ILE R C   1 
ATOM   112  O O   . ILE A 1 185 ? 137.467 150.752 125.463 1.00 37.74  ? 47  ILE R O   1 
ATOM   113  C CB  . ILE A 1 185 ? 134.666 152.632 125.221 1.00 34.53  ? 47  ILE R CB  1 
ATOM   114  C CG1 . ILE A 1 185 ? 134.444 154.082 124.791 1.00 43.36  ? 47  ILE R CG1 1 
ATOM   115  C CG2 . ILE A 1 185 ? 135.076 152.557 126.679 1.00 31.98  ? 47  ILE R CG2 1 
ATOM   116  C CD1 . ILE A 1 185 ? 133.232 154.718 125.433 1.00 41.56  ? 47  ILE R CD1 1 
ATOM   117  N N   . ILE A 1 186 ? 135.553 149.641 125.015 1.00 39.05  ? 48  ILE R N   1 
ATOM   118  C CA  . ILE A 1 186 ? 136.066 148.397 125.575 1.00 32.66  ? 48  ILE R CA  1 
ATOM   119  C C   . ILE A 1 186 ? 137.292 147.939 124.800 1.00 38.87  ? 48  ILE R C   1 
ATOM   120  O O   . ILE A 1 186 ? 138.243 147.412 125.380 1.00 42.63  ? 48  ILE R O   1 
ATOM   121  C CB  . ILE A 1 186 ? 134.973 147.314 125.587 1.00 31.93  ? 48  ILE R CB  1 
ATOM   122  C CG1 . ILE A 1 186 ? 133.797 147.731 126.467 1.00 40.37  ? 48  ILE R CG1 1 
ATOM   123  C CG2 . ILE A 1 186 ? 135.542 145.995 126.078 1.00 27.27  ? 48  ILE R CG2 1 
ATOM   124  C CD1 . ILE A 1 186 ? 132.625 146.788 126.370 1.00 38.07  ? 48  ILE R CD1 1 
ATOM   125  N N   . PHE A 1 187 ? 137.296 148.137 123.481 1.00 36.74  ? 49  PHE R N   1 
ATOM   126  C CA  . PHE A 1 187 ? 138.416 147.671 122.670 1.00 28.98  ? 49  PHE R CA  1 
ATOM   127  C C   . PHE A 1 187 ? 139.703 148.410 123.018 1.00 40.63  ? 49  PHE R C   1 
ATOM   128  O O   . PHE A 1 187 ? 140.746 147.785 123.238 1.00 53.28  ? 49  PHE R O   1 
ATOM   129  C CB  . PHE A 1 187 ? 138.092 147.828 121.187 1.00 36.70  ? 49  PHE R CB  1 
ATOM   130  C CG  . PHE A 1 187 ? 139.301 147.847 120.306 1.00 33.97  ? 49  PHE R CG  1 
ATOM   131  C CD1 . PHE A 1 187 ? 139.977 146.677 120.027 1.00 29.66  ? 49  PHE R CD1 1 
ATOM   132  C CD2 . PHE A 1 187 ? 139.752 149.026 119.744 1.00 41.06  ? 49  PHE R CD2 1 
ATOM   133  C CE1 . PHE A 1 187 ? 141.086 146.679 119.212 1.00 39.01  ? 49  PHE R CE1 1 
ATOM   134  C CE2 . PHE A 1 187 ? 140.863 149.035 118.927 1.00 42.39  ? 49  PHE R CE2 1 
ATOM   135  C CZ  . PHE A 1 187 ? 141.531 147.859 118.661 1.00 42.47  ? 49  PHE R CZ  1 
ATOM   136  N N   . LEU A 1 188 ? 139.653 149.746 123.062 1.00 51.33  ? 50  LEU R N   1 
ATOM   137  C CA  . LEU A 1 188 ? 140.849 150.506 123.431 1.00 54.79  ? 50  LEU R CA  1 
ATOM   138  C C   . LEU A 1 188 ? 141.317 150.161 124.837 1.00 45.61  ? 50  LEU R C   1 
ATOM   139  O O   . LEU A 1 188 ? 142.515 149.940 125.067 1.00 41.07  ? 50  LEU R O   1 
ATOM   140  C CB  . LEU A 1 188 ? 140.623 152.016 123.309 1.00 51.26  ? 50  LEU R CB  1 
ATOM   141  C CG  . LEU A 1 188 ? 140.651 152.741 121.956 1.00 53.25  ? 50  LEU R CG  1 
ATOM   142  C CD1 . LEU A 1 188 ? 139.465 152.456 121.069 1.00 45.23  ? 50  LEU R CD1 1 
ATOM   143  C CD2 . LEU A 1 188 ? 140.776 154.242 122.172 1.00 57.17  ? 50  LEU R CD2 1 
ATOM   144  N N   . THR A 1 189 ? 140.389 150.117 125.798 1.00 32.34  ? 51  THR R N   1 
ATOM   145  C CA  . THR A 1 189 ? 140.797 149.822 127.167 1.00 32.51  ? 51  THR R CA  1 
ATOM   146  C C   . THR A 1 189 ? 141.383 148.421 127.275 1.00 37.03  ? 51  THR R C   1 
ATOM   147  O O   . THR A 1 189 ? 142.379 148.211 127.977 1.00 49.80  ? 51  THR R O   1 
ATOM   148  C CB  . THR A 1 189 ? 139.619 149.996 128.124 1.00 39.95  ? 51  THR R CB  1 
ATOM   149  O OG1 . THR A 1 189 ? 138.494 149.245 127.650 1.00 59.13  ? 51  THR R OG1 1 
ATOM   150  C CG2 . THR A 1 189 ? 139.243 151.462 128.231 1.00 40.20  ? 51  THR R CG2 1 
ATOM   151  N N   . GLY A 1 190 ? 140.792 147.452 126.574 1.00 32.30  ? 52  GLY R N   1 
ATOM   152  C CA  . GLY A 1 190 ? 141.313 146.099 126.611 1.00 28.80  ? 52  GLY R CA  1 
ATOM   153  C C   . GLY A 1 190 ? 142.698 145.995 126.009 1.00 36.69  ? 52  GLY R C   1 
ATOM   154  O O   . GLY A 1 190 ? 143.598 145.406 126.607 1.00 42.92  ? 52  GLY R O   1 
ATOM   155  N N   . ILE A 1 191 ? 142.898 146.590 124.828 1.00 37.84  ? 53  ILE R N   1 
ATOM   156  C CA  . ILE A 1 191 ? 144.230 146.569 124.227 1.00 32.88  ? 53  ILE R CA  1 
ATOM   157  C C   . ILE A 1 191 ? 145.246 147.175 125.180 1.00 44.29  ? 53  ILE R C   1 
ATOM   158  O O   . ILE A 1 191 ? 146.250 146.539 125.520 1.00 48.29  ? 53  ILE R O   1 
ATOM   159  C CB  . ILE A 1 191 ? 144.240 147.294 122.869 1.00 39.42  ? 53  ILE R CB  1 
ATOM   160  C CG1 . ILE A 1 191 ? 143.314 146.608 121.871 1.00 47.01  ? 53  ILE R CG1 1 
ATOM   161  C CG2 . ILE A 1 191 ? 145.651 147.347 122.313 1.00 44.81  ? 53  ILE R CG2 1 
ATOM   162  C CD1 . ILE A 1 191 ? 143.727 145.188 121.551 1.00 45.21  ? 53  ILE R CD1 1 
ATOM   163  N N   . VAL A 1 192 ? 144.968 148.378 125.688 1.00 53.60  ? 54  VAL R N   1 
ATOM   164  C CA  . VAL A 1 192 ? 145.954 149.063 126.520 1.00 53.23  ? 54  VAL R CA  1 
ATOM   165  C C   . VAL A 1 192 ? 146.256 148.248 127.774 1.00 49.36  ? 54  VAL R C   1 
ATOM   166  O O   . VAL A 1 192 ? 147.409 147.873 128.029 1.00 52.87  ? 54  VAL R O   1 
ATOM   167  C CB  . VAL A 1 192 ? 145.471 150.482 126.869 1.00 53.85  ? 54  VAL R CB  1 
ATOM   168  C CG1 . VAL A 1 192 ? 146.259 151.039 128.044 1.00 53.38  ? 54  VAL R CG1 1 
ATOM   169  C CG2 . VAL A 1 192 ? 145.594 151.393 125.657 1.00 51.95  ? 54  VAL R CG2 1 
ATOM   170  N N   . GLY A 1 193 ? 145.221 147.933 128.556 1.00 41.94  ? 55  GLY R N   1 
ATOM   171  C CA  . GLY A 1 193 ? 145.448 147.264 129.826 1.00 39.51  ? 55  GLY R CA  1 
ATOM   172  C C   . GLY A 1 193 ? 146.033 145.873 129.672 1.00 50.86  ? 55  GLY R C   1 
ATOM   173  O O   . GLY A 1 193 ? 146.997 145.516 130.356 1.00 57.88  ? 55  GLY R O   1 
ATOM   174  N N   . ASN A 1 194 ? 145.461 145.063 128.776 1.00 49.19  ? 56  ASN R N   1 
ATOM   175  C CA  . ASN A 1 194 ? 145.923 143.690 128.632 1.00 38.54  ? 56  ASN R CA  1 
ATOM   176  C C   . ASN A 1 194 ? 147.320 143.633 128.035 1.00 43.13  ? 56  ASN R C   1 
ATOM   177  O O   . ASN A 1 194 ? 148.139 142.812 128.458 1.00 54.98  ? 56  ASN R O   1 
ATOM   178  C CB  . ASN A 1 194 ? 144.933 142.892 127.789 1.00 38.55  ? 56  ASN R CB  1 
ATOM   179  C CG  . ASN A 1 194 ? 143.749 142.411 128.596 1.00 43.50  ? 56  ASN R CG  1 
ATOM   180  O OD1 . ASN A 1 194 ? 143.905 141.930 129.716 1.00 45.69  ? 56  ASN R OD1 1 
ATOM   181  N ND2 . ASN A 1 194 ? 142.554 142.547 128.036 1.00 43.36  ? 56  ASN R ND2 1 
ATOM   182  N N   . GLY A 1 195 ? 147.622 144.489 127.054 1.00 49.54  ? 57  GLY R N   1 
ATOM   183  C CA  . GLY A 1 195 ? 148.978 144.545 126.547 1.00 55.46  ? 57  GLY R CA  1 
ATOM   184  C C   . GLY A 1 195 ? 149.971 144.952 127.615 1.00 51.29  ? 57  GLY R C   1 
ATOM   185  O O   . GLY A 1 195 ? 151.049 144.363 127.727 1.00 47.50  ? 57  GLY R O   1 
ATOM   186  N N   . LEU A 1 196 ? 149.616 145.950 128.429 1.00 57.56  ? 58  LEU R N   1 
ATOM   187  C CA  . LEU A 1 196 ? 150.514 146.370 129.499 1.00 58.09  ? 58  LEU R CA  1 
ATOM   188  C C   . LEU A 1 196 ? 150.759 145.233 130.483 1.00 61.87  ? 58  LEU R C   1 
ATOM   189  O O   . LEU A 1 196 ? 151.906 144.953 130.853 1.00 69.47  ? 58  LEU R O   1 
ATOM   190  C CB  . LEU A 1 196 ? 149.939 147.592 130.214 1.00 53.98  ? 58  LEU R CB  1 
ATOM   191  C CG  . LEU A 1 196 ? 150.174 148.937 129.529 1.00 60.97  ? 58  LEU R CG  1 
ATOM   192  C CD1 . LEU A 1 196 ? 149.714 150.079 130.419 1.00 64.20  ? 58  LEU R CD1 1 
ATOM   193  C CD2 . LEU A 1 196 ? 151.639 149.097 129.160 1.00 63.51  ? 58  LEU R CD2 1 
ATOM   194  N N   . VAL A 1 197 ? 149.691 144.546 130.894 1.00 58.06  ? 59  VAL R N   1 
ATOM   195  C CA  . VAL A 1 197 ? 149.830 143.461 131.863 1.00 56.19  ? 59  VAL R CA  1 
ATOM   196  C C   . VAL A 1 197 ? 150.676 142.335 131.284 1.00 61.40  ? 59  VAL R C   1 
ATOM   197  O O   . VAL A 1 197 ? 151.584 141.815 131.944 1.00 65.44  ? 59  VAL R O   1 
ATOM   198  C CB  . VAL A 1 197 ? 148.447 142.953 132.303 1.00 54.33  ? 59  VAL R CB  1 
ATOM   199  C CG1 . VAL A 1 197 ? 148.584 141.658 133.083 1.00 48.48  ? 59  VAL R CG1 1 
ATOM   200  C CG2 . VAL A 1 197 ? 147.737 144.006 133.130 1.00 57.93  ? 59  VAL R CG2 1 
ATOM   201  N N   . ILE A 1 198 ? 150.391 141.942 130.040 1.00 55.77  ? 60  ILE R N   1 
ATOM   202  C CA  . ILE A 1 198 ? 151.102 140.822 129.433 1.00 48.81  ? 60  ILE R CA  1 
ATOM   203  C C   . ILE A 1 198 ? 152.576 141.155 129.258 1.00 50.75  ? 60  ILE R C   1 
ATOM   204  O O   . ILE A 1 198 ? 153.446 140.345 129.589 1.00 54.99  ? 60  ILE R O   1 
ATOM   205  C CB  . ILE A 1 198 ? 150.441 140.426 128.100 1.00 50.79  ? 60  ILE R CB  1 
ATOM   206  C CG1 . ILE A 1 198 ? 149.108 139.727 128.362 1.00 50.30  ? 60  ILE R CG1 1 
ATOM   207  C CG2 . ILE A 1 198 ? 151.358 139.523 127.296 1.00 52.83  ? 60  ILE R CG2 1 
ATOM   208  C CD1 . ILE A 1 198 ? 148.453 139.176 127.121 1.00 47.88  ? 60  ILE R CD1 1 
ATOM   209  N N   . LEU A 1 199 ? 152.886 142.354 128.758 1.00 59.25  ? 61  LEU R N   1 
ATOM   210  C CA  . LEU A 1 199 ? 154.285 142.742 128.608 1.00 65.28  ? 61  LEU R CA  1 
ATOM   211  C C   . LEU A 1 199 ? 154.997 142.769 129.956 1.00 74.26  ? 61  LEU R C   1 
ATOM   212  O O   . LEU A 1 199 ? 156.090 142.206 130.104 1.00 76.19  ? 61  LEU R O   1 
ATOM   213  C CB  . LEU A 1 199 ? 154.385 144.103 127.917 1.00 65.73  ? 61  LEU R CB  1 
ATOM   214  C CG  . LEU A 1 199 ? 154.476 144.141 126.387 1.00 75.08  ? 61  LEU R CG  1 
ATOM   215  C CD1 . LEU A 1 199 ? 155.777 143.505 125.921 1.00 73.27  ? 61  LEU R CD1 1 
ATOM   216  C CD2 . LEU A 1 199 ? 153.286 143.464 125.722 1.00 74.94  ? 61  LEU R CD2 1 
ATOM   217  N N   . VAL A 1 200 ? 154.371 143.386 130.964 1.00 73.30  ? 62  VAL R N   1 
ATOM   218  C CA  . VAL A 1 200 ? 155.022 143.556 132.261 1.00 62.27  ? 62  VAL R CA  1 
ATOM   219  C C   . VAL A 1 200 ? 155.288 142.204 132.912 1.00 72.54  ? 62  VAL R C   1 
ATOM   220  O O   . VAL A 1 200 ? 156.378 141.955 133.439 1.00 80.69  ? 62  VAL R O   1 
ATOM   221  C CB  . VAL A 1 200 ? 154.174 144.465 133.168 1.00 58.22  ? 62  VAL R CB  1 
ATOM   222  C CG1 . VAL A 1 200 ? 154.562 144.280 134.620 1.00 62.58  ? 62  VAL R CG1 1 
ATOM   223  C CG2 . VAL A 1 200 ? 154.341 145.915 132.756 1.00 69.32  ? 62  VAL R CG2 1 
ATOM   224  N N   . MET A 1 201 ? 154.305 141.306 132.880 1.00 72.94  ? 63  MET R N   1 
ATOM   225  C CA  . MET A 1 201 ? 154.437 140.027 133.562 1.00 68.90  ? 63  MET R CA  1 
ATOM   226  C C   . MET A 1 201 ? 154.987 138.917 132.676 1.00 68.49  ? 63  MET R C   1 
ATOM   227  O O   . MET A 1 201 ? 155.109 137.781 133.143 1.00 72.03  ? 63  MET R O   1 
ATOM   228  C CB  . MET A 1 201 ? 153.089 139.603 134.151 1.00 66.73  ? 63  MET R CB  1 
ATOM   229  C CG  . MET A 1 201 ? 152.842 140.177 135.533 1.00 73.09  ? 63  MET R CG  1 
ATOM   230  S SD  . MET A 1 201 ? 151.138 140.053 136.097 1.00 84.03  ? 63  MET R SD  1 
ATOM   231  C CE  . MET A 1 201 ? 151.265 140.900 137.669 1.00 67.13  ? 63  MET R CE  1 
ATOM   232  N N   . GLY A 1 202 ? 155.322 139.205 131.421 1.00 76.21  ? 64  GLY R N   1 
ATOM   233  C CA  . GLY A 1 202 ? 155.931 138.198 130.581 1.00 81.05  ? 64  GLY R CA  1 
ATOM   234  C C   . GLY A 1 202 ? 157.377 138.482 130.239 1.00 79.93  ? 64  GLY R C   1 
ATOM   235  O O   . GLY A 1 202 ? 158.175 137.551 130.104 1.00 85.18  ? 64  GLY R O   1 
ATOM   236  N N   . TYR A 1 203 ? 157.734 139.757 130.091 1.00 83.03  ? 65  TYR R N   1 
ATOM   237  C CA  . TYR A 1 203 ? 159.104 140.113 129.750 1.00 88.06  ? 65  TYR R CA  1 
ATOM   238  C C   . TYR A 1 203 ? 159.823 140.900 130.832 1.00 90.90  ? 65  TYR R C   1 
ATOM   239  O O   . TYR A 1 203 ? 161.031 140.721 131.001 1.00 93.51  ? 65  TYR R O   1 
ATOM   240  C CB  . TYR A 1 203 ? 159.137 140.912 128.441 1.00 89.47  ? 65  TYR R CB  1 
ATOM   241  C CG  . TYR A 1 203 ? 158.554 140.164 127.264 1.00 88.96  ? 65  TYR R CG  1 
ATOM   242  C CD1 . TYR A 1 203 ? 159.305 139.217 126.580 1.00 86.36  ? 65  TYR R CD1 1 
ATOM   243  C CD2 . TYR A 1 203 ? 157.252 140.397 126.842 1.00 88.73  ? 65  TYR R CD2 1 
ATOM   244  C CE1 . TYR A 1 203 ? 158.778 138.527 125.505 1.00 88.86  ? 65  TYR R CE1 1 
ATOM   245  C CE2 . TYR A 1 203 ? 156.716 139.712 125.768 1.00 90.20  ? 65  TYR R CE2 1 
ATOM   246  C CZ  . TYR A 1 203 ? 157.483 138.778 125.104 1.00 92.10  ? 65  TYR R CZ  1 
ATOM   247  O OH  . TYR A 1 203 ? 156.954 138.093 124.034 1.00 90.94  ? 65  TYR R OH  1 
ATOM   248  N N   . GLN A 1 204 ? 159.120 141.759 131.568 1.00 90.17  ? 66  GLN R N   1 
ATOM   249  C CA  . GLN A 1 204 ? 159.748 142.517 132.641 1.00 88.17  ? 66  GLN R CA  1 
ATOM   250  C C   . GLN A 1 204 ? 159.822 141.741 133.950 1.00 88.47  ? 66  GLN R C   1 
ATOM   251  O O   . GLN A 1 204 ? 160.434 142.233 134.904 1.00 84.10  ? 66  GLN R O   1 
ATOM   252  C CB  . GLN A 1 204 ? 159.005 143.837 132.855 1.00 83.64  ? 66  GLN R CB  1 
ATOM   253  C CG  . GLN A 1 204 ? 158.510 144.487 131.570 1.00 85.36  ? 66  GLN R CG  1 
ATOM   254  C CD  . GLN A 1 204 ? 159.601 144.649 130.524 1.00 88.28  ? 66  GLN R CD  1 
ATOM   255  O OE1 . GLN A 1 204 ? 160.768 144.865 130.852 1.00 87.33  ? 66  GLN R OE1 1 
ATOM   256  N NE2 . GLN A 1 204 ? 159.223 144.543 129.256 1.00 86.98  ? 66  GLN R NE2 1 
ATOM   257  N N   . LYS A 1 205 ? 159.217 140.554 134.012 1.00 91.37  ? 67  LYS R N   1 
ATOM   258  C CA  . LYS A 1 205 ? 159.350 139.636 135.144 1.00 88.09  ? 67  LYS R CA  1 
ATOM   259  C C   . LYS A 1 205 ? 158.923 140.292 136.458 1.00 88.95  ? 67  LYS R C   1 
ATOM   260  O O   . LYS A 1 205 ? 159.698 140.411 137.409 1.00 96.20  ? 67  LYS R O   1 
ATOM   261  C CB  . LYS A 1 205 ? 160.780 139.093 135.237 1.00 91.25  ? 67  LYS R CB  1 
ATOM   262  C CG  . LYS A 1 205 ? 161.255 138.287 134.028 1.00 92.47  ? 67  LYS R CG  1 
ATOM   263  C CD  . LYS A 1 205 ? 160.585 136.915 133.936 1.00 90.92  ? 67  LYS R CD  1 
ATOM   264  C CE  . LYS A 1 205 ? 159.359 136.916 133.034 1.00 90.11  ? 67  LYS R CE  1 
ATOM   265  N NZ  . LYS A 1 205 ? 158.788 135.550 132.876 1.00 90.31  ? 67  LYS R NZ  1 
ATOM   266  N N   . LYS A 1 206 ? 157.664 140.722 136.496 1.00 86.89  ? 68  LYS R N   1 
ATOM   267  C CA  . LYS A 1 206 ? 157.049 141.206 137.723 1.00 92.84  ? 68  LYS R CA  1 
ATOM   268  C C   . LYS A 1 206 ? 156.110 140.177 138.339 1.00 94.91  ? 68  LYS R C   1 
ATOM   269  O O   . LYS A 1 206 ? 155.343 140.512 139.247 1.00 97.59  ? 68  LYS R O   1 
ATOM   270  C CB  . LYS A 1 206 ? 156.306 142.520 137.469 1.00 90.74  ? 68  LYS R CB  1 
ATOM   271  C CG  . LYS A 1 206 ? 157.218 143.735 137.362 1.00 90.41  ? 68  LYS R CG  1 
ATOM   272  C CD  . LYS A 1 206 ? 156.457 145.025 137.627 1.00 92.05  ? 68  LYS R CD  1 
ATOM   273  C CE  . LYS A 1 206 ? 157.391 146.225 137.673 1.00 89.73  ? 68  LYS R CE  1 
ATOM   274  N NZ  . LYS A 1 206 ? 157.911 146.586 136.326 1.00 88.81  ? 68  LYS R NZ  1 
ATOM   275  N N   . LEU A 1 207 ? 156.154 138.933 137.865 1.00 89.51  ? 69  LEU R N   1 
ATOM   276  C CA  . LEU A 1 207 ? 155.304 137.882 138.409 1.00 91.76  ? 69  LEU R CA  1 
ATOM   277  C C   . LEU A 1 207 ? 155.774 137.501 139.808 1.00 93.43  ? 69  LEU R C   1 
ATOM   278  O O   . LEU A 1 207 ? 156.963 137.256 140.029 1.00 90.46  ? 69  LEU R O   1 
ATOM   279  C CB  . LEU A 1 207 ? 155.325 136.666 137.482 1.00 88.45  ? 69  LEU R CB  1 
ATOM   280  C CG  . LEU A 1 207 ? 154.310 135.542 137.700 1.00 86.43  ? 69  LEU R CG  1 
ATOM   281  C CD1 . LEU A 1 207 ? 153.939 134.920 136.365 1.00 87.95  ? 69  LEU R CD1 1 
ATOM   282  C CD2 . LEU A 1 207 ? 154.851 134.480 138.646 1.00 88.53  ? 69  LEU R CD2 1 
ATOM   283  N N   . ARG A 1 208 ? 154.836 137.450 140.754 1.00 96.41  ? 70  ARG R N   1 
ATOM   284  C CA  . ARG A 1 208 ? 155.153 137.150 142.147 1.00 93.03  ? 70  ARG R CA  1 
ATOM   285  C C   . ARG A 1 208 ? 154.830 135.707 142.522 1.00 94.12  ? 70  ARG R C   1 
ATOM   286  O O   . ARG A 1 208 ? 155.714 134.964 142.958 1.00 96.93  ? 70  ARG R O   1 
ATOM   287  C CB  . ARG A 1 208 ? 154.404 138.116 143.076 1.00 94.04  ? 70  ARG R CB  1 
ATOM   288  C CG  . ARG A 1 208 ? 154.721 137.927 144.551 1.00 94.50  ? 70  ARG R CG  1 
ATOM   289  C CD  . ARG A 1 208 ? 153.875 138.846 145.417 1.00 96.06  ? 70  ARG R CD  1 
ATOM   290  N NE  . ARG A 1 208 ? 152.452 138.567 145.271 1.00 96.83  ? 70  ARG R NE  1 
ATOM   291  C CZ  . ARG A 1 208 ? 151.558 139.440 144.827 1.00 97.31  ? 70  ARG R CZ  1 
ATOM   292  N NH1 . ARG A 1 208 ? 151.905 140.669 144.481 1.00 95.89  ? 70  ARG R NH1 1 
ATOM   293  N NH2 . ARG A 1 208 ? 150.284 139.071 144.728 1.00 95.77  ? 70  ARG R NH2 1 
ATOM   294  N N   . SER A 1 209 ? 153.576 135.293 142.355 1.00 82.49  ? 71  SER R N   1 
ATOM   295  C CA  . SER A 1 209 ? 153.125 133.990 142.828 1.00 79.58  ? 71  SER R CA  1 
ATOM   296  C C   . SER A 1 209 ? 152.182 133.389 141.791 1.00 82.97  ? 71  SER R C   1 
ATOM   297  O O   . SER A 1 209 ? 152.090 133.863 140.654 1.00 91.82  ? 71  SER R O   1 
ATOM   298  C CB  . SER A 1 209 ? 152.468 134.117 144.209 1.00 81.51  ? 71  SER R CB  1 
ATOM   299  O OG  . SER A 1 209 ? 151.292 134.905 144.142 1.00 82.62  ? 71  SER R OG  1 
ATOM   300  N N   . MET A 1 210 ? 151.475 132.329 142.193 1.00 68.18  ? 72  MET R N   1 
ATOM   301  C CA  . MET A 1 210 ? 150.614 131.604 141.264 1.00 68.64  ? 72  MET R CA  1 
ATOM   302  C C   . MET A 1 210 ? 149.422 132.441 140.816 1.00 69.31  ? 72  MET R C   1 
ATOM   303  O O   . MET A 1 210 ? 148.954 132.295 139.676 1.00 79.98  ? 72  MET R O   1 
ATOM   304  C CB  . MET A 1 210 ? 150.140 130.304 141.910 1.00 67.63  ? 72  MET R CB  1 
ATOM   305  C CG  . MET A 1 210 ? 151.207 129.602 142.733 1.00 70.86  ? 72  MET R CG  1 
ATOM   306  S SD  . MET A 1 210 ? 152.812 129.572 141.914 1.00 84.26  ? 72  MET R SD  1 
ATOM   307  C CE  . MET A 1 210 ? 153.726 128.480 142.999 1.00 70.52  ? 72  MET R CE  1 
ATOM   308  N N   . THR A 1 211 ? 148.914 133.310 141.692 1.00 49.02  ? 73  THR R N   1 
ATOM   309  C CA  . THR A 1 211 ? 147.809 134.181 141.310 1.00 55.06  ? 73  THR R CA  1 
ATOM   310  C C   . THR A 1 211 ? 148.192 135.057 140.124 1.00 63.80  ? 73  THR R C   1 
ATOM   311  O O   . THR A 1 211 ? 147.361 135.336 139.252 1.00 71.13  ? 73  THR R O   1 
ATOM   312  C CB  . THR A 1 211 ? 147.381 135.035 142.503 1.00 53.23  ? 73  THR R CB  1 
ATOM   313  O OG1 . THR A 1 211 ? 146.983 134.180 143.582 1.00 54.61  ? 73  THR R OG1 1 
ATOM   314  C CG2 . THR A 1 211 ? 146.214 135.932 142.131 1.00 62.80  ? 73  THR R CG2 1 
ATOM   315  N N   . ASP A 1 212 ? 149.457 135.473 140.057 1.00 66.75  ? 74  ASP R N   1 
ATOM   316  C CA  . ASP A 1 212 ? 149.913 136.257 138.916 1.00 64.90  ? 74  ASP R CA  1 
ATOM   317  C C   . ASP A 1 212 ? 149.941 135.423 137.640 1.00 64.33  ? 74  ASP R C   1 
ATOM   318  O O   . ASP A 1 212 ? 149.645 135.936 136.557 1.00 70.48  ? 74  ASP R O   1 
ATOM   319  C CB  . ASP A 1 212 ? 151.286 136.854 139.209 1.00 66.41  ? 74  ASP R CB  1 
ATOM   320  C CG  . ASP A 1 212 ? 151.226 137.951 140.247 1.00 73.80  ? 74  ASP R CG  1 
ATOM   321  O OD1 . ASP A 1 212 ? 150.102 138.348 140.622 1.00 72.50  ? 74  ASP R OD1 1 
ATOM   322  O OD2 . ASP A 1 212 ? 152.296 138.419 140.687 1.00 75.97  ? 74  ASP R OD2 1 
ATOM   323  N N   . LYS A 1 213 ? 150.286 134.137 137.740 1.00 53.09  ? 75  LYS R N   1 
ATOM   324  C CA  . LYS A 1 213 ? 150.212 133.265 136.570 1.00 56.94  ? 75  LYS R CA  1 
ATOM   325  C C   . LYS A 1 213 ? 148.777 133.134 136.073 1.00 58.38  ? 75  LYS R C   1 
ATOM   326  O O   . LYS A 1 213 ? 148.512 133.205 134.861 1.00 67.92  ? 75  LYS R O   1 
ATOM   327  C CB  . LYS A 1 213 ? 150.782 131.887 136.903 1.00 56.39  ? 75  LYS R CB  1 
ATOM   328  C CG  . LYS A 1 213 ? 152.198 131.901 137.441 1.00 55.74  ? 75  LYS R CG  1 
ATOM   329  C CD  . LYS A 1 213 ? 152.692 130.487 137.690 1.00 56.93  ? 75  LYS R CD  1 
ATOM   330  C CE  . LYS A 1 213 ? 154.150 130.474 138.113 1.00 64.20  ? 75  LYS R CE  1 
ATOM   331  N NZ  . LYS A 1 213 ? 154.344 131.103 139.448 1.00 66.12  ? 75  LYS R NZ  1 
ATOM   332  N N   . TYR A 1 214 ? 147.834 132.940 136.997 1.00 42.51  ? 76  TYR R N   1 
ATOM   333  C CA  . TYR A 1 214 ? 146.434 132.847 136.596 1.00 38.80  ? 76  TYR R CA  1 
ATOM   334  C C   . TYR A 1 214 ? 145.960 134.147 135.960 1.00 49.10  ? 76  TYR R C   1 
ATOM   335  O O   . TYR A 1 214 ? 145.210 134.132 134.975 1.00 60.26  ? 76  TYR R O   1 
ATOM   336  C CB  . TYR A 1 214 ? 145.563 132.495 137.797 1.00 41.39  ? 76  TYR R CB  1 
ATOM   337  C CG  . TYR A 1 214 ? 146.051 131.317 138.604 1.00 47.12  ? 76  TYR R CG  1 
ATOM   338  C CD1 . TYR A 1 214 ? 146.543 130.177 137.986 1.00 49.63  ? 76  TYR R CD1 1 
ATOM   339  C CD2 . TYR A 1 214 ? 146.009 131.344 139.989 1.00 47.35  ? 76  TYR R CD2 1 
ATOM   340  C CE1 . TYR A 1 214 ? 146.986 129.100 138.728 1.00 50.89  ? 76  TYR R CE1 1 
ATOM   341  C CE2 . TYR A 1 214 ? 146.448 130.276 140.737 1.00 49.71  ? 76  TYR R CE2 1 
ATOM   342  C CZ  . TYR A 1 214 ? 146.935 129.156 140.104 1.00 55.79  ? 76  TYR R CZ  1 
ATOM   343  O OH  . TYR A 1 214 ? 147.370 128.093 140.860 1.00 57.68  ? 76  TYR R OH  1 
ATOM   344  N N   . ARG A 1 215 ? 146.385 135.285 136.509 1.00 51.76  ? 77  ARG R N   1 
ATOM   345  C CA  . ARG A 1 215 ? 146.009 136.565 135.922 1.00 54.02  ? 77  ARG R CA  1 
ATOM   346  C C   . ARG A 1 215 ? 146.653 136.765 134.555 1.00 54.59  ? 77  ARG R C   1 
ATOM   347  O O   . ARG A 1 215 ? 146.062 137.411 133.687 1.00 60.97  ? 77  ARG R O   1 
ATOM   348  C CB  . ARG A 1 215 ? 146.374 137.703 136.871 1.00 54.00  ? 77  ARG R CB  1 
ATOM   349  C CG  . ARG A 1 215 ? 145.363 137.895 137.992 1.00 54.33  ? 77  ARG R CG  1 
ATOM   350  C CD  . ARG A 1 215 ? 145.954 138.672 139.149 1.00 52.37  ? 77  ARG R CD  1 
ATOM   351  N NE  . ARG A 1 215 ? 144.927 139.163 140.058 1.00 56.73  ? 77  ARG R NE  1 
ATOM   352  C CZ  . ARG A 1 215 ? 144.345 140.350 139.958 1.00 60.48  ? 77  ARG R CZ  1 
ATOM   353  N NH1 . ARG A 1 215 ? 144.633 141.179 138.969 1.00 58.99  ? 77  ARG R NH1 1 
ATOM   354  N NH2 . ARG A 1 215 ? 143.445 140.710 140.867 1.00 60.20  ? 77  ARG R NH2 1 
ATOM   355  N N   . LEU A 1 216 ? 147.849 136.214 134.342 1.00 50.29  ? 78  LEU R N   1 
ATOM   356  C CA  . LEU A 1 216 ? 148.457 136.242 133.015 1.00 42.50  ? 78  LEU R CA  1 
ATOM   357  C C   . LEU A 1 216 ? 147.620 135.461 132.009 1.00 43.63  ? 78  LEU R C   1 
ATOM   358  O O   . LEU A 1 216 ? 147.409 135.912 130.875 1.00 54.22  ? 78  LEU R O   1 
ATOM   359  C CB  . LEU A 1 216 ? 149.874 135.676 133.084 1.00 39.18  ? 78  LEU R CB  1 
ATOM   360  C CG  . LEU A 1 216 ? 150.762 135.837 131.852 1.00 41.92  ? 78  LEU R CG  1 
ATOM   361  C CD1 . LEU A 1 216 ? 151.016 137.302 131.571 1.00 56.67  ? 78  LEU R CD1 1 
ATOM   362  C CD2 . LEU A 1 216 ? 152.069 135.090 132.046 1.00 46.87  ? 78  LEU R CD2 1 
ATOM   363  N N   . HIS A 1 217 ? 147.140 134.281 132.407 1.00 33.76  ? 79  HIS R N   1 
ATOM   364  C CA  . HIS A 1 217 ? 146.274 133.507 131.516 1.00 35.97  ? 79  HIS R CA  1 
ATOM   365  C C   . HIS A 1 217 ? 144.974 134.256 131.223 1.00 38.98  ? 79  HIS R C   1 
ATOM   366  O O   . HIS A 1 217 ? 144.496 134.283 130.075 1.00 47.77  ? 79  HIS R O   1 
ATOM   367  C CB  . HIS A 1 217 ? 145.984 132.139 132.130 1.00 39.92  ? 79  HIS R CB  1 
ATOM   368  C CG  . HIS A 1 217 ? 147.201 131.282 132.304 1.00 42.27  ? 79  HIS R CG  1 
ATOM   369  N ND1 . HIS A 1 217 ? 147.134 129.977 132.743 1.00 43.03  ? 79  HIS R ND1 1 
ATOM   370  C CD2 . HIS A 1 217 ? 148.513 131.542 132.098 1.00 44.68  ? 79  HIS R CD2 1 
ATOM   371  C CE1 . HIS A 1 217 ? 148.353 129.471 132.801 1.00 42.95  ? 79  HIS R CE1 1 
ATOM   372  N NE2 . HIS A 1 217 ? 149.208 130.400 132.415 1.00 47.59  ? 79  HIS R NE2 1 
ATOM   373  N N   . LEU A 1 218 ? 144.395 134.878 132.254 1.00 35.44  ? 80  LEU R N   1 
ATOM   374  C CA  . LEU A 1 218 ? 143.207 135.705 132.062 1.00 37.61  ? 80  LEU R CA  1 
ATOM   375  C C   . LEU A 1 218 ? 143.476 136.834 131.077 1.00 42.27  ? 80  LEU R C   1 
ATOM   376  O O   . LEU A 1 218 ? 142.641 137.131 130.214 1.00 44.51  ? 80  LEU R O   1 
ATOM   377  C CB  . LEU A 1 218 ? 142.746 136.280 133.400 1.00 35.72  ? 80  LEU R CB  1 
ATOM   378  C CG  . LEU A 1 218 ? 141.978 135.387 134.370 1.00 42.32  ? 80  LEU R CG  1 
ATOM   379  C CD1 . LEU A 1 218 ? 141.905 136.043 135.735 1.00 37.77  ? 80  LEU R CD1 1 
ATOM   380  C CD2 . LEU A 1 218 ? 140.587 135.126 133.839 1.00 48.16  ? 80  LEU R CD2 1 
ATOM   381  N N   . SER A 1 219 ? 144.635 137.484 131.203 1.00 39.48  ? 81  SER R N   1 
ATOM   382  C CA  . SER A 1 219 ? 144.976 138.586 130.314 1.00 30.86  ? 81  SER R CA  1 
ATOM   383  C C   . SER A 1 219 ? 145.132 138.110 128.878 1.00 37.39  ? 81  SER R C   1 
ATOM   384  O O   . SER A 1 219 ? 144.737 138.810 127.944 1.00 43.08  ? 81  SER R O   1 
ATOM   385  C CB  . SER A 1 219 ? 146.251 139.272 130.795 1.00 43.03  ? 81  SER R CB  1 
ATOM   386  O OG  . SER A 1 219 ? 145.988 140.095 131.918 1.00 51.84  ? 81  SER R OG  1 
ATOM   387  N N   . VAL A 1 220 ? 145.704 136.921 128.680 1.00 41.53  ? 82  VAL R N   1 
ATOM   388  C CA  . VAL A 1 220 ? 145.834 136.385 127.324 1.00 37.71  ? 82  VAL R CA  1 
ATOM   389  C C   . VAL A 1 220 ? 144.457 136.165 126.700 1.00 40.64  ? 82  VAL R C   1 
ATOM   390  O O   . VAL A 1 220 ? 144.191 136.583 125.560 1.00 58.38  ? 82  VAL R O   1 
ATOM   391  C CB  . VAL A 1 220 ? 146.662 135.088 127.334 1.00 34.03  ? 82  VAL R CB  1 
ATOM   392  C CG1 . VAL A 1 220 ? 146.450 134.316 126.045 1.00 33.62  ? 82  VAL R CG1 1 
ATOM   393  C CG2 . VAL A 1 220 ? 148.133 135.402 127.534 1.00 34.20  ? 82  VAL R CG2 1 
ATOM   394  N N   . ALA A 1 221 ? 143.557 135.512 127.441 1.00 33.53  ? 83  ALA R N   1 
ATOM   395  C CA  . ALA A 1 221 ? 142.220 135.266 126.899 1.00 32.78  ? 83  ALA R CA  1 
ATOM   396  C C   . ALA A 1 221 ? 141.487 136.574 126.605 1.00 40.63  ? 83  ALA R C   1 
ATOM   397  O O   . ALA A 1 221 ? 140.860 136.733 125.541 1.00 46.90  ? 83  ALA R O   1 
ATOM   398  C CB  . ALA A 1 221 ? 141.413 134.404 127.867 1.00 39.58  ? 83  ALA R CB  1 
ATOM   399  N N   . ASP A 1 222 ? 141.562 137.529 127.535 1.00 43.45  ? 84  ASP R N   1 
ATOM   400  C CA  . ASP A 1 222 ? 140.896 138.807 127.333 1.00 40.89  ? 84  ASP R CA  1 
ATOM   401  C C   . ASP A 1 222 ? 141.498 139.573 126.166 1.00 48.41  ? 84  ASP R C   1 
ATOM   402  O O   . ASP A 1 222 ? 140.773 140.270 125.452 1.00 54.56  ? 84  ASP R O   1 
ATOM   403  C CB  . ASP A 1 222 ? 140.959 139.638 128.613 1.00 49.22  ? 84  ASP R CB  1 
ATOM   404  C CG  . ASP A 1 222 ? 140.197 138.999 129.758 1.00 58.64  ? 84  ASP R CG  1 
ATOM   405  O OD1 . ASP A 1 222 ? 139.568 137.943 129.537 1.00 52.02  ? 84  ASP R OD1 1 
ATOM   406  O OD2 . ASP A 1 222 ? 140.228 139.551 130.878 1.00 64.44  ? 84  ASP R OD2 1 
ATOM   407  N N   . LEU A 1 223 ? 142.811 139.459 125.952 1.00 43.15  ? 85  LEU R N   1 
ATOM   408  C CA  . LEU A 1 223 ? 143.431 140.105 124.803 1.00 34.50  ? 85  LEU R CA  1 
ATOM   409  C C   . LEU A 1 223 ? 142.909 139.518 123.503 1.00 31.22  ? 85  LEU R C   1 
ATOM   410  O O   . LEU A 1 223 ? 142.657 140.253 122.542 1.00 44.27  ? 85  LEU R O   1 
ATOM   411  C CB  . LEU A 1 223 ? 144.951 139.971 124.878 1.00 35.90  ? 85  LEU R CB  1 
ATOM   412  C CG  . LEU A 1 223 ? 145.731 140.516 123.681 1.00 41.19  ? 85  LEU R CG  1 
ATOM   413  C CD1 . LEU A 1 223 ? 145.411 141.982 123.456 1.00 42.67  ? 85  LEU R CD1 1 
ATOM   414  C CD2 . LEU A 1 223 ? 147.223 140.317 123.871 1.00 45.20  ? 85  LEU R CD2 1 
ATOM   415  N N   . LEU A 1 224 ? 142.737 138.196 123.453 1.00 24.88  ? 86  LEU R N   1 
ATOM   416  C CA  . LEU A 1 224 ? 142.169 137.585 122.252 1.00 31.25  ? 86  LEU R CA  1 
ATOM   417  C C   . LEU A 1 224 ? 140.768 138.123 121.969 1.00 37.51  ? 86  LEU R C   1 
ATOM   418  O O   . LEU A 1 224 ? 140.449 138.515 120.834 1.00 41.68  ? 86  LEU R O   1 
ATOM   419  C CB  . LEU A 1 224 ? 142.145 136.063 122.395 1.00 40.60  ? 86  LEU R CB  1 
ATOM   420  C CG  . LEU A 1 224 ? 143.320 135.291 121.791 1.00 41.53  ? 86  LEU R CG  1 
ATOM   421  C CD1 . LEU A 1 224 ? 143.322 135.430 120.279 1.00 39.18  ? 86  LEU R CD1 1 
ATOM   422  C CD2 . LEU A 1 224 ? 144.646 135.752 122.371 1.00 35.20  ? 86  LEU R CD2 1 
ATOM   423  N N   . PHE A 1 225 ? 139.918 138.172 122.997 1.00 36.29  ? 87  PHE R N   1 
ATOM   424  C CA  . PHE A 1 225 ? 138.560 138.671 122.768 1.00 28.51  ? 87  PHE R CA  1 
ATOM   425  C C   . PHE A 1 225 ? 138.556 140.154 122.390 1.00 40.47  ? 87  PHE R C   1 
ATOM   426  O O   . PHE A 1 225 ? 137.762 140.590 121.544 1.00 43.62  ? 87  PHE R O   1 
ATOM   427  C CB  . PHE A 1 225 ? 137.683 138.436 123.992 1.00 39.42  ? 87  PHE R CB  1 
ATOM   428  C CG  . PHE A 1 225 ? 136.241 138.774 123.761 1.00 42.98  ? 87  PHE R CG  1 
ATOM   429  C CD1 . PHE A 1 225 ? 135.554 138.217 122.700 1.00 43.14  ? 87  PHE R CD1 1 
ATOM   430  C CD2 . PHE A 1 225 ? 135.580 139.658 124.589 1.00 43.13  ? 87  PHE R CD2 1 
ATOM   431  C CE1 . PHE A 1 225 ? 134.233 138.528 122.474 1.00 39.09  ? 87  PHE R CE1 1 
ATOM   432  C CE2 . PHE A 1 225 ? 134.257 139.972 124.369 1.00 47.81  ? 87  PHE R CE2 1 
ATOM   433  C CZ  . PHE A 1 225 ? 133.583 139.405 123.310 1.00 40.00  ? 87  PHE R CZ  1 
ATOM   434  N N   . VAL A 1 226 ? 139.422 140.951 123.015 1.00 39.74  ? 88  VAL R N   1 
ATOM   435  C CA  . VAL A 1 226 ? 139.470 142.373 122.697 1.00 26.50  ? 88  VAL R CA  1 
ATOM   436  C C   . VAL A 1 226 ? 139.947 142.579 121.265 1.00 39.85  ? 88  VAL R C   1 
ATOM   437  O O   . VAL A 1 226 ? 139.477 143.483 120.564 1.00 53.67  ? 88  VAL R O   1 
ATOM   438  C CB  . VAL A 1 226 ? 140.354 143.111 123.718 1.00 28.80  ? 88  VAL R CB  1 
ATOM   439  C CG1 . VAL A 1 226 ? 140.719 144.482 123.212 1.00 39.28  ? 88  VAL R CG1 1 
ATOM   440  C CG2 . VAL A 1 226 ? 139.636 143.216 125.050 1.00 45.24  ? 88  VAL R CG2 1 
ATOM   441  N N   . ILE A 1 227 ? 140.873 141.736 120.800 1.00 41.60  ? 89  ILE R N   1 
ATOM   442  C CA  . ILE A 1 227 ? 141.277 141.773 119.398 1.00 27.33  ? 89  ILE R CA  1 
ATOM   443  C C   . ILE A 1 227 ? 140.094 141.467 118.491 1.00 28.24  ? 89  ILE R C   1 
ATOM   444  O O   . ILE A 1 227 ? 139.928 142.088 117.434 1.00 36.33  ? 89  ILE R O   1 
ATOM   445  C CB  . ILE A 1 227 ? 142.448 140.804 119.147 1.00 30.38  ? 89  ILE R CB  1 
ATOM   446  C CG1 . ILE A 1 227 ? 143.752 141.377 119.704 1.00 43.82  ? 89  ILE R CG1 1 
ATOM   447  C CG2 . ILE A 1 227 ? 142.592 140.493 117.667 1.00 30.45  ? 89  ILE R CG2 1 
ATOM   448  C CD1 . ILE A 1 227 ? 144.921 140.422 119.610 1.00 43.37  ? 89  ILE R CD1 1 
ATOM   449  N N   . THR A 1 228 ? 139.252 140.507 118.877 1.00 32.44  ? 90  THR R N   1 
ATOM   450  C CA  . THR A 1 228 ? 138.143 140.176 117.984 1.00 33.67  ? 90  THR R CA  1 
ATOM   451  C C   . THR A 1 228 ? 136.974 141.159 118.064 1.00 29.70  ? 90  THR R C   1 
ATOM   452  O O   . THR A 1 228 ? 136.078 141.088 117.218 1.00 27.50  ? 90  THR R O   1 
ATOM   453  C CB  . THR A 1 228 ? 137.626 138.759 118.247 1.00 46.55  ? 90  THR R CB  1 
ATOM   454  O OG1 . THR A 1 228 ? 136.873 138.319 117.114 1.00 44.38  ? 90  THR R OG1 1 
ATOM   455  C CG2 . THR A 1 228 ? 136.708 138.731 119.443 1.00 41.58  ? 90  THR R CG2 1 
ATOM   456  N N   . LEU A 1 229 ? 136.952 142.055 119.053 1.00 36.33  ? 91  LEU R N   1 
ATOM   457  C CA  . LEU A 1 229 ? 135.837 143.000 119.176 1.00 31.29  ? 91  LEU R CA  1 
ATOM   458  C C   . LEU A 1 229 ? 135.590 143.916 117.969 1.00 35.67  ? 91  LEU R C   1 
ATOM   459  O O   . LEU A 1 229 ? 134.410 144.116 117.620 1.00 49.68  ? 91  LEU R O   1 
ATOM   460  C CB  . LEU A 1 229 ? 136.022 143.855 120.436 1.00 22.66  ? 91  LEU R CB  1 
ATOM   461  C CG  . LEU A 1 229 ? 135.497 143.271 121.745 1.00 31.64  ? 91  LEU R CG  1 
ATOM   462  C CD1 . LEU A 1 229 ? 135.874 144.163 122.909 1.00 36.78  ? 91  LEU R CD1 1 
ATOM   463  C CD2 . LEU A 1 229 ? 133.995 143.091 121.676 1.00 36.11  ? 91  LEU R CD2 1 
ATOM   464  N N   . PRO A 1 230 ? 136.597 144.530 117.330 1.00 35.75  ? 92  PRO R N   1 
ATOM   465  C CA  . PRO A 1 230 ? 136.290 145.502 116.261 1.00 35.62  ? 92  PRO R CA  1 
ATOM   466  C C   . PRO A 1 230 ? 135.464 144.941 115.116 1.00 42.72  ? 92  PRO R C   1 
ATOM   467  O O   . PRO A 1 230 ? 134.699 145.691 114.493 1.00 41.55  ? 92  PRO R O   1 
ATOM   468  C CB  . PRO A 1 230 ? 137.679 145.939 115.781 1.00 33.26  ? 92  PRO R CB  1 
ATOM   469  C CG  . PRO A 1 230 ? 138.539 145.764 116.957 1.00 36.25  ? 92  PRO R CG  1 
ATOM   470  C CD  . PRO A 1 230 ? 138.032 144.541 117.662 1.00 37.06  ? 92  PRO R CD  1 
ATOM   471  N N   . PHE A 1 231 ? 135.603 143.652 114.804 1.00 53.10  ? 93  PHE R N   1 
ATOM   472  C CA  . PHE A 1 231 ? 134.737 143.050 113.797 1.00 44.94  ? 93  PHE R CA  1 
ATOM   473  C C   . PHE A 1 231 ? 133.281 143.101 114.234 1.00 48.45  ? 93  PHE R C   1 
ATOM   474  O O   . PHE A 1 231 ? 132.392 143.381 113.423 1.00 50.88  ? 93  PHE R O   1 
ATOM   475  C CB  . PHE A 1 231 ? 135.168 141.611 113.520 1.00 44.94  ? 93  PHE R CB  1 
ATOM   476  C CG  . PHE A 1 231 ? 136.493 141.502 112.832 1.00 46.79  ? 93  PHE R CG  1 
ATOM   477  C CD1 . PHE A 1 231 ? 136.580 141.586 111.455 1.00 46.08  ? 93  PHE R CD1 1 
ATOM   478  C CD2 . PHE A 1 231 ? 137.653 141.320 113.561 1.00 52.48  ? 93  PHE R CD2 1 
ATOM   479  C CE1 . PHE A 1 231 ? 137.798 141.488 110.818 1.00 48.93  ? 93  PHE R CE1 1 
ATOM   480  C CE2 . PHE A 1 231 ? 138.874 141.221 112.930 1.00 52.11  ? 93  PHE R CE2 1 
ATOM   481  C CZ  . PHE A 1 231 ? 138.947 141.305 111.556 1.00 51.81  ? 93  PHE R CZ  1 
ATOM   482  N N   . TRP A 1 232 ? 133.019 142.843 115.517 1.00 50.82  ? 94  TRP R N   1 
ATOM   483  C CA  . TRP A 1 232 ? 131.662 142.973 116.034 1.00 46.07  ? 94  TRP R CA  1 
ATOM   484  C C   . TRP A 1 232 ? 131.181 144.415 115.961 1.00 46.26  ? 94  TRP R C   1 
ATOM   485  O O   . TRP A 1 232 ? 130.009 144.672 115.662 1.00 54.07  ? 94  TRP R O   1 
ATOM   486  C CB  . TRP A 1 232 ? 131.591 142.456 117.470 1.00 44.11  ? 94  TRP R CB  1 
ATOM   487  C CG  . TRP A 1 232 ? 131.691 140.971 117.567 1.00 45.97  ? 94  TRP R CG  1 
ATOM   488  C CD1 . TRP A 1 232 ? 132.604 140.258 118.282 1.00 42.90  ? 94  TRP R CD1 1 
ATOM   489  C CD2 . TRP A 1 232 ? 130.847 140.009 116.922 1.00 55.49  ? 94  TRP R CD2 1 
ATOM   490  N NE1 . TRP A 1 232 ? 132.382 138.912 118.126 1.00 44.00  ? 94  TRP R NE1 1 
ATOM   491  C CE2 . TRP A 1 232 ? 131.308 138.734 117.295 1.00 53.72  ? 94  TRP R CE2 1 
ATOM   492  C CE3 . TRP A 1 232 ? 129.744 140.104 116.067 1.00 58.30  ? 94  TRP R CE3 1 
ATOM   493  C CZ2 . TRP A 1 232 ? 130.707 137.562 116.842 1.00 57.99  ? 94  TRP R CZ2 1 
ATOM   494  C CZ3 . TRP A 1 232 ? 129.150 138.941 115.618 1.00 50.09  ? 94  TRP R CZ3 1 
ATOM   495  C CH2 . TRP A 1 232 ? 129.632 137.687 116.007 1.00 51.69  ? 94  TRP R CH2 1 
ATOM   496  N N   . ALA A 1 233 ? 132.071 145.371 116.236 1.00 46.91  ? 95  ALA R N   1 
ATOM   497  C CA  . ALA A 1 233 ? 131.692 146.777 116.109 1.00 41.67  ? 95  ALA R CA  1 
ATOM   498  C C   . ALA A 1 233 ? 131.255 147.103 114.684 1.00 44.47  ? 95  ALA R C   1 
ATOM   499  O O   . ALA A 1 233 ? 130.182 147.681 114.464 1.00 48.51  ? 95  ALA R O   1 
ATOM   500  C CB  . ALA A 1 233 ? 132.853 147.675 116.533 1.00 50.69  ? 95  ALA R CB  1 
ATOM   501  N N   . VAL A 1 234 ? 132.072 146.721 113.699 1.00 58.91  ? 96  VAL R N   1 
ATOM   502  C CA  . VAL A 1 234 ? 131.744 147.007 112.303 1.00 59.07  ? 96  VAL R CA  1 
ATOM   503  C C   . VAL A 1 234 ? 130.469 146.282 111.892 1.00 54.03  ? 96  VAL R C   1 
ATOM   504  O O   . VAL A 1 234 ? 129.648 146.817 111.138 1.00 55.30  ? 96  VAL R O   1 
ATOM   505  C CB  . VAL A 1 234 ? 132.925 146.642 111.384 1.00 59.35  ? 96  VAL R CB  1 
ATOM   506  C CG1 . VAL A 1 234 ? 132.536 146.815 109.925 1.00 50.76  ? 96  VAL R CG1 1 
ATOM   507  C CG2 . VAL A 1 234 ? 134.138 147.495 111.713 1.00 60.93  ? 96  VAL R CG2 1 
ATOM   508  N N   . ASP A 1 235 ? 130.279 145.054 112.384 1.00 59.16  ? 97  ASP R N   1 
ATOM   509  C CA  . ASP A 1 235 ? 129.049 144.324 112.101 1.00 59.51  ? 97  ASP R CA  1 
ATOM   510  C C   . ASP A 1 235 ? 127.833 145.067 112.633 1.00 60.60  ? 97  ASP R C   1 
ATOM   511  O O   . ASP A 1 235 ? 126.804 145.156 111.954 1.00 61.37  ? 97  ASP R O   1 
ATOM   512  C CB  . ASP A 1 235 ? 129.120 142.924 112.707 1.00 64.19  ? 97  ASP R CB  1 
ATOM   513  C CG  . ASP A 1 235 ? 127.921 142.072 112.348 1.00 68.47  ? 97  ASP R CG  1 
ATOM   514  O OD1 . ASP A 1 235 ? 127.838 141.617 111.189 1.00 72.07  ? 97  ASP R OD1 1 
ATOM   515  O OD2 . ASP A 1 235 ? 127.060 141.859 113.226 1.00 67.37  ? 97  ASP R OD2 1 
ATOM   516  N N   . ALA A 1 236 ? 127.931 145.604 113.849 1.00 63.46  ? 98  ALA R N   1 
ATOM   517  C CA  . ALA A 1 236 ? 126.805 146.331 114.419 1.00 57.09  ? 98  ALA R CA  1 
ATOM   518  C C   . ALA A 1 236 ? 126.572 147.658 113.709 1.00 56.21  ? 98  ALA R C   1 
ATOM   519  O O   . ALA A 1 236 ? 125.445 148.165 113.712 1.00 53.01  ? 98  ALA R O   1 
ATOM   520  C CB  . ALA A 1 236 ? 127.024 146.560 115.913 1.00 59.91  ? 98  ALA R CB  1 
ATOM   521  N N   . VAL A 1 237 ? 127.609 148.237 113.101 1.00 70.82  ? 99  VAL R N   1 
ATOM   522  C CA  . VAL A 1 237 ? 127.441 149.534 112.450 1.00 68.55  ? 99  VAL R CA  1 
ATOM   523  C C   . VAL A 1 237 ? 126.621 149.399 111.172 1.00 63.79  ? 99  VAL R C   1 
ATOM   524  O O   . VAL A 1 237 ? 125.495 149.903 111.092 1.00 64.42  ? 99  VAL R O   1 
ATOM   525  C CB  . VAL A 1 237 ? 128.800 150.190 112.139 1.00 69.63  ? 99  VAL R CB  1 
ATOM   526  C CG1 . VAL A 1 237 ? 128.607 151.423 111.267 1.00 63.53  ? 99  VAL R CG1 1 
ATOM   527  C CG2 . VAL A 1 237 ? 129.523 150.565 113.414 1.00 65.82  ? 99  VAL R CG2 1 
ATOM   528  N N   . ALA A 1 238 ? 127.171 148.719 110.165 1.00 69.50  ? 100 ALA R N   1 
ATOM   529  C CA  . ALA A 1 238 ? 126.536 148.671 108.851 1.00 71.24  ? 100 ALA R CA  1 
ATOM   530  C C   . ALA A 1 238 ? 126.227 147.256 108.382 1.00 73.95  ? 100 ALA R C   1 
ATOM   531  O O   . ALA A 1 238 ? 125.069 146.957 108.074 1.00 77.04  ? 100 ALA R O   1 
ATOM   532  C CB  . ALA A 1 238 ? 127.422 149.389 107.825 1.00 73.31  ? 100 ALA R CB  1 
ATOM   533  N N   . ASN A 1 239 ? 127.218 146.377 108.322 1.00 84.28  ? 101 ASN R N   1 
ATOM   534  C CA  . ASN A 1 239 ? 127.083 145.090 107.642 1.00 81.34  ? 101 ASN R CA  1 
ATOM   535  C C   . ASN A 1 239 ? 128.304 144.243 107.986 1.00 81.46  ? 101 ASN R C   1 
ATOM   536  O O   . ASN A 1 239 ? 129.123 144.622 108.833 1.00 87.46  ? 101 ASN R O   1 
ATOM   537  C CB  . ASN A 1 239 ? 126.925 145.285 106.133 1.00 79.92  ? 101 ASN R CB  1 
ATOM   538  C CG  . ASN A 1 239 ? 126.165 144.156 105.475 1.00 83.87  ? 101 ASN R CG  1 
ATOM   539  O OD1 . ASN A 1 239 ? 125.929 143.115 106.086 1.00 90.07  ? 101 ASN R OD1 1 
ATOM   540  N ND2 . ASN A 1 239 ? 125.781 144.352 104.219 1.00 82.40  ? 101 ASN R ND2 1 
ATOM   541  N N   . TRP A 1 240 ? 128.429 143.093 107.326 1.00 70.74  ? 102 TRP R N   1 
ATOM   542  C CA  . TRP A 1 240 ? 129.543 142.171 107.534 1.00 69.05  ? 102 TRP R CA  1 
ATOM   543  C C   . TRP A 1 240 ? 130.181 141.874 106.184 1.00 72.31  ? 102 TRP R C   1 
ATOM   544  O O   . TRP A 1 240 ? 129.615 141.127 105.379 1.00 73.40  ? 102 TRP R O   1 
ATOM   545  C CB  . TRP A 1 240 ? 129.067 140.885 108.211 1.00 66.45  ? 102 TRP R CB  1 
ATOM   546  C CG  . TRP A 1 240 ? 130.156 139.897 108.484 1.00 65.12  ? 102 TRP R CG  1 
ATOM   547  C CD1 . TRP A 1 240 ? 130.632 138.945 107.633 1.00 67.94  ? 102 TRP R CD1 1 
ATOM   548  C CD2 . TRP A 1 240 ? 130.899 139.755 109.700 1.00 67.33  ? 102 TRP R CD2 1 
ATOM   549  N NE1 . TRP A 1 240 ? 131.630 138.223 108.240 1.00 66.17  ? 102 TRP R NE1 1 
ATOM   550  C CE2 . TRP A 1 240 ? 131.813 138.702 109.510 1.00 67.38  ? 102 TRP R CE2 1 
ATOM   551  C CE3 . TRP A 1 240 ? 130.883 140.419 110.929 1.00 69.11  ? 102 TRP R CE3 1 
ATOM   552  C CZ2 . TRP A 1 240 ? 132.700 138.297 110.502 1.00 71.30  ? 102 TRP R CZ2 1 
ATOM   553  C CZ3 . TRP A 1 240 ? 131.764 140.016 111.912 1.00 66.38  ? 102 TRP R CZ3 1 
ATOM   554  C CH2 . TRP A 1 240 ? 132.659 138.966 111.694 1.00 65.87  ? 102 TRP R CH2 1 
ATOM   555  N N   . TYR A 1 241 ? 131.356 142.449 105.938 1.00 80.21  ? 103 TYR R N   1 
ATOM   556  C CA  . TYR A 1 241 ? 132.092 142.266 104.690 1.00 80.01  ? 103 TYR R CA  1 
ATOM   557  C C   . TYR A 1 241 ? 133.374 141.467 104.904 1.00 82.64  ? 103 TYR R C   1 
ATOM   558  O O   . TYR A 1 241 ? 134.387 141.707 104.245 1.00 86.28  ? 103 TYR R O   1 
ATOM   559  C CB  . TYR A 1 241 ? 132.433 143.611 104.054 1.00 79.13  ? 103 TYR R CB  1 
ATOM   560  C CG  . TYR A 1 241 ? 131.306 144.615 104.021 1.00 80.54  ? 103 TYR R CG  1 
ATOM   561  C CD1 . TYR A 1 241 ? 130.096 144.313 103.413 1.00 79.69  ? 103 TYR R CD1 1 
ATOM   562  C CD2 . TYR A 1 241 ? 131.460 145.874 104.586 1.00 81.60  ? 103 TYR R CD2 1 
ATOM   563  C CE1 . TYR A 1 241 ? 129.068 145.233 103.375 1.00 80.69  ? 103 TYR R CE1 1 
ATOM   564  C CE2 . TYR A 1 241 ? 130.438 146.801 104.554 1.00 83.89  ? 103 TYR R CE2 1 
ATOM   565  C CZ  . TYR A 1 241 ? 129.244 146.476 103.947 1.00 84.12  ? 103 TYR R CZ  1 
ATOM   566  O OH  . TYR A 1 241 ? 128.222 147.397 103.914 1.00 86.14  ? 103 TYR R OH  1 
ATOM   567  N N   . PHE A 1 242 ? 133.350 140.504 105.821 1.00 73.27  ? 104 PHE R N   1 
ATOM   568  C CA  . PHE A 1 242 ? 134.576 139.849 106.258 1.00 66.19  ? 104 PHE R CA  1 
ATOM   569  C C   . PHE A 1 242 ? 134.666 138.392 105.834 1.00 68.92  ? 104 PHE R C   1 
ATOM   570  O O   . PHE A 1 242 ? 135.735 137.949 105.396 1.00 69.89  ? 104 PHE R O   1 
ATOM   571  C CB  . PHE A 1 242 ? 134.707 139.983 107.780 1.00 64.14  ? 104 PHE R CB  1 
ATOM   572  C CG  . PHE A 1 242 ? 134.655 141.405 108.259 1.00 66.02  ? 104 PHE R CG  1 
ATOM   573  C CD1 . PHE A 1 242 ? 135.746 142.241 108.098 1.00 67.36  ? 104 PHE R CD1 1 
ATOM   574  C CD2 . PHE A 1 242 ? 133.514 141.911 108.853 1.00 68.33  ? 104 PHE R CD2 1 
ATOM   575  C CE1 . PHE A 1 242 ? 135.703 143.549 108.531 1.00 67.27  ? 104 PHE R CE1 1 
ATOM   576  C CE2 . PHE A 1 242 ? 133.465 143.220 109.288 1.00 65.70  ? 104 PHE R CE2 1 
ATOM   577  C CZ  . PHE A 1 242 ? 134.562 144.039 109.126 1.00 67.89  ? 104 PHE R CZ  1 
ATOM   578  N N   . GLY A 1 243 ? 133.589 137.626 105.948 1.00 81.67  ? 105 GLY R N   1 
ATOM   579  C CA  . GLY A 1 243 ? 133.540 136.298 105.370 1.00 81.62  ? 105 GLY R CA  1 
ATOM   580  C C   . GLY A 1 243 ? 133.184 135.228 106.385 1.00 88.03  ? 105 GLY R C   1 
ATOM   581  O O   . GLY A 1 243 ? 133.210 135.432 107.598 1.00 87.97  ? 105 GLY R O   1 
ATOM   582  N N   . ASN A 1 244 ? 132.856 134.054 105.839 1.00 78.97  ? 106 ASN R N   1 
ATOM   583  C CA  . ASN A 1 244 ? 132.466 132.911 106.657 1.00 74.65  ? 106 ASN R CA  1 
ATOM   584  C C   . ASN A 1 244 ? 133.608 132.451 107.554 1.00 77.87  ? 106 ASN R C   1 
ATOM   585  O O   . ASN A 1 244 ? 133.391 132.094 108.720 1.00 79.13  ? 106 ASN R O   1 
ATOM   586  C CB  . ASN A 1 244 ? 131.999 131.773 105.750 1.00 66.16  ? 106 ASN R CB  1 
ATOM   587  C CG  . ASN A 1 244 ? 131.232 130.709 106.496 1.00 77.24  ? 106 ASN R CG  1 
ATOM   588  O OD1 . ASN A 1 244 ? 131.019 130.811 107.702 1.00 84.28  ? 106 ASN R OD1 1 
ATOM   589  N ND2 . ASN A 1 244 ? 130.806 129.677 105.778 1.00 79.13  ? 106 ASN R ND2 1 
ATOM   590  N N   . PHE A 1 245 ? 134.833 132.437 107.022 1.00 68.94  ? 107 PHE R N   1 
ATOM   591  C CA  . PHE A 1 245 ? 135.979 132.022 107.824 1.00 65.14  ? 107 PHE R CA  1 
ATOM   592  C C   . PHE A 1 245 ? 136.189 132.958 109.006 1.00 69.77  ? 107 PHE R C   1 
ATOM   593  O O   . PHE A 1 245 ? 136.447 132.505 110.128 1.00 81.10  ? 107 PHE R O   1 
ATOM   594  C CB  . PHE A 1 245 ? 137.233 131.963 106.955 1.00 66.74  ? 107 PHE R CB  1 
ATOM   595  C CG  . PHE A 1 245 ? 138.495 131.730 107.731 1.00 71.64  ? 107 PHE R CG  1 
ATOM   596  C CD1 . PHE A 1 245 ? 138.596 130.669 108.613 1.00 71.42  ? 107 PHE R CD1 1 
ATOM   597  C CD2 . PHE A 1 245 ? 139.581 132.575 107.580 1.00 75.24  ? 107 PHE R CD2 1 
ATOM   598  C CE1 . PHE A 1 245 ? 139.755 130.453 109.330 1.00 70.17  ? 107 PHE R CE1 1 
ATOM   599  C CE2 . PHE A 1 245 ? 140.745 132.364 108.293 1.00 75.24  ? 107 PHE R CE2 1 
ATOM   600  C CZ  . PHE A 1 245 ? 140.832 131.301 109.169 1.00 71.20  ? 107 PHE R CZ  1 
ATOM   601  N N   . LEU A 1 246 ? 136.071 134.268 108.780 1.00 63.48  ? 108 LEU R N   1 
ATOM   602  C CA  . LEU A 1 246 ? 136.218 135.209 109.883 1.00 65.08  ? 108 LEU R CA  1 
ATOM   603  C C   . LEU A 1 246 ? 135.068 135.096 110.874 1.00 70.36  ? 108 LEU R C   1 
ATOM   604  O O   . LEU A 1 246 ? 135.277 135.270 112.080 1.00 74.44  ? 108 LEU R O   1 
ATOM   605  C CB  . LEU A 1 246 ? 136.335 136.635 109.350 1.00 64.62  ? 108 LEU R CB  1 
ATOM   606  C CG  . LEU A 1 246 ? 137.771 137.065 109.043 1.00 67.12  ? 108 LEU R CG  1 
ATOM   607  C CD1 . LEU A 1 246 ? 137.856 138.557 108.785 1.00 71.39  ? 108 LEU R CD1 1 
ATOM   608  C CD2 . LEU A 1 246 ? 138.703 136.666 110.175 1.00 63.49  ? 108 LEU R CD2 1 
ATOM   609  N N   . CYS A 1 247 ? 133.857 134.799 110.396 1.00 63.00  ? 109 CYS R N   1 
ATOM   610  C CA  . CYS A 1 247 ? 132.743 134.551 111.307 1.00 61.85  ? 109 CYS R CA  1 
ATOM   611  C C   . CYS A 1 247 ? 133.047 133.376 112.231 1.00 61.66  ? 109 CYS R C   1 
ATOM   612  O O   . CYS A 1 247 ? 132.883 133.464 113.458 1.00 65.59  ? 109 CYS R O   1 
ATOM   613  C CB  . CYS A 1 247 ? 131.469 134.290 110.503 1.00 56.13  ? 109 CYS R CB  1 
ATOM   614  S SG  . CYS A 1 247 ? 129.922 134.509 111.410 1.00 82.40  ? 109 CYS R SG  1 
ATOM   615  N N   . LYS A 1 248 ? 133.509 132.266 111.653 1.00 48.35  ? 110 LYS R N   1 
ATOM   616  C CA  . LYS A 1 248 ? 133.857 131.105 112.464 1.00 45.79  ? 110 LYS R CA  1 
ATOM   617  C C   . LYS A 1 248 ? 134.973 131.438 113.444 1.00 47.73  ? 110 LYS R C   1 
ATOM   618  O O   . LYS A 1 248 ? 134.928 131.030 114.611 1.00 54.54  ? 110 LYS R O   1 
ATOM   619  C CB  . LYS A 1 248 ? 134.262 129.938 111.565 1.00 42.75  ? 110 LYS R CB  1 
ATOM   620  C CG  . LYS A 1 248 ? 133.100 129.252 110.871 1.00 41.83  ? 110 LYS R CG  1 
ATOM   621  C CD  . LYS A 1 248 ? 133.576 128.071 110.046 1.00 46.09  ? 110 LYS R CD  1 
ATOM   622  C CE  . LYS A 1 248 ? 132.604 127.749 108.928 1.00 46.29  ? 110 LYS R CE  1 
ATOM   623  N NZ  . LYS A 1 248 ? 131.222 127.560 109.436 1.00 46.16  ? 110 LYS R NZ  1 
ATOM   624  N N   . ALA A 1 249 ? 135.981 132.187 112.987 1.00 38.66  ? 111 ALA R N   1 
ATOM   625  C CA  . ALA A 1 249 ? 137.103 132.529 113.854 1.00 34.93  ? 111 ALA R CA  1 
ATOM   626  C C   . ALA A 1 249 ? 136.659 133.378 115.039 1.00 46.21  ? 111 ALA R C   1 
ATOM   627  O O   . ALA A 1 249 ? 137.074 133.128 116.176 1.00 52.19  ? 111 ALA R O   1 
ATOM   628  C CB  . ALA A 1 249 ? 138.183 133.254 113.052 1.00 35.21  ? 111 ALA R CB  1 
ATOM   629  N N   . VAL A 1 250 ? 135.813 134.383 114.799 1.00 50.48  ? 112 VAL R N   1 
ATOM   630  C CA  . VAL A 1 250 ? 135.401 135.253 115.896 1.00 43.62  ? 112 VAL R CA  1 
ATOM   631  C C   . VAL A 1 250 ? 134.514 134.493 116.878 1.00 50.32  ? 112 VAL R C   1 
ATOM   632  O O   . VAL A 1 250 ? 134.617 134.686 118.096 1.00 56.18  ? 112 VAL R O   1 
ATOM   633  C CB  . VAL A 1 250 ? 134.723 136.534 115.368 1.00 36.40  ? 112 VAL R CB  1 
ATOM   634  C CG1 . VAL A 1 250 ? 135.665 137.291 114.449 1.00 40.20  ? 112 VAL R CG1 1 
ATOM   635  C CG2 . VAL A 1 250 ? 133.421 136.231 114.660 1.00 47.67  ? 112 VAL R CG2 1 
ATOM   636  N N   . HIS A 1 251 ? 133.652 133.600 116.379 1.00 47.49  ? 113 HIS R N   1 
ATOM   637  C CA  . HIS A 1 251 ? 132.831 132.802 117.290 1.00 46.11  ? 113 HIS R CA  1 
ATOM   638  C C   . HIS A 1 251 ? 133.696 131.883 118.149 1.00 48.57  ? 113 HIS R C   1 
ATOM   639  O O   . HIS A 1 251 ? 133.485 131.761 119.366 1.00 44.53  ? 113 HIS R O   1 
ATOM   640  C CB  . HIS A 1 251 ? 131.804 131.997 116.497 1.00 39.84  ? 113 HIS R CB  1 
ATOM   641  C CG  . HIS A 1 251 ? 130.580 132.776 116.138 1.00 42.90  ? 113 HIS R CG  1 
ATOM   642  N ND1 . HIS A 1 251 ? 130.375 133.300 114.880 1.00 51.33  ? 113 HIS R ND1 1 
ATOM   643  C CD2 . HIS A 1 251 ? 129.498 133.126 116.872 1.00 46.41  ? 113 HIS R CD2 1 
ATOM   644  C CE1 . HIS A 1 251 ? 129.218 133.937 114.854 1.00 48.67  ? 113 HIS R CE1 1 
ATOM   645  N NE2 . HIS A 1 251 ? 128.666 133.846 116.050 1.00 47.52  ? 113 HIS R NE2 1 
ATOM   646  N N   . VAL A 1 252 ? 134.686 131.235 117.528 1.00 42.51  ? 114 VAL R N   1 
ATOM   647  C CA  . VAL A 1 252 ? 135.584 130.353 118.267 1.00 39.53  ? 114 VAL R CA  1 
ATOM   648  C C   . VAL A 1 252 ? 136.339 131.135 119.333 1.00 37.61  ? 114 VAL R C   1 
ATOM   649  O O   . VAL A 1 252 ? 136.460 130.689 120.483 1.00 48.26  ? 114 VAL R O   1 
ATOM   650  C CB  . VAL A 1 252 ? 136.546 129.644 117.295 1.00 37.88  ? 114 VAL R CB  1 
ATOM   651  C CG1 . VAL A 1 252 ? 137.773 129.131 118.029 1.00 41.06  ? 114 VAL R CG1 1 
ATOM   652  C CG2 . VAL A 1 252 ? 135.836 128.513 116.576 1.00 36.53  ? 114 VAL R CG2 1 
ATOM   653  N N   . ILE A 1 253 ? 136.854 132.313 118.972 1.00 28.50  ? 115 ILE R N   1 
ATOM   654  C CA  . ILE A 1 253 ? 137.613 133.119 119.923 1.00 30.62  ? 115 ILE R CA  1 
ATOM   655  C C   . ILE A 1 253 ? 136.731 133.541 121.090 1.00 33.87  ? 115 ILE R C   1 
ATOM   656  O O   . ILE A 1 253 ? 137.149 133.489 122.253 1.00 43.76  ? 115 ILE R O   1 
ATOM   657  C CB  . ILE A 1 253 ? 138.238 134.333 119.214 1.00 39.42  ? 115 ILE R CB  1 
ATOM   658  C CG1 . ILE A 1 253 ? 139.392 133.888 118.314 1.00 39.16  ? 115 ILE R CG1 1 
ATOM   659  C CG2 . ILE A 1 253 ? 138.719 135.355 120.229 1.00 45.44  ? 115 ILE R CG2 1 
ATOM   660  C CD1 . ILE A 1 253 ? 140.155 135.034 117.686 1.00 36.84  ? 115 ILE R CD1 1 
ATOM   661  N N   . TYR A 1 254 ? 135.497 133.963 120.801 1.00 34.03  ? 116 TYR R N   1 
ATOM   662  C CA  . TYR A 1 254 ? 134.592 134.388 121.864 1.00 37.88  ? 116 TYR R CA  1 
ATOM   663  C C   . TYR A 1 254 ? 134.317 133.253 122.842 1.00 52.35  ? 116 TYR R C   1 
ATOM   664  O O   . TYR A 1 254 ? 134.398 133.437 124.066 1.00 55.91  ? 116 TYR R O   1 
ATOM   665  C CB  . TYR A 1 254 ? 133.290 134.907 121.256 1.00 37.78  ? 116 TYR R CB  1 
ATOM   666  C CG  . TYR A 1 254 ? 132.133 134.970 122.225 1.00 37.49  ? 116 TYR R CG  1 
ATOM   667  C CD1 . TYR A 1 254 ? 132.101 135.914 123.239 1.00 42.44  ? 116 TYR R CD1 1 
ATOM   668  C CD2 . TYR A 1 254 ? 131.068 134.089 122.118 1.00 39.39  ? 116 TYR R CD2 1 
ATOM   669  C CE1 . TYR A 1 254 ? 131.043 135.976 124.123 1.00 45.88  ? 116 TYR R CE1 1 
ATOM   670  C CE2 . TYR A 1 254 ? 130.006 134.143 122.997 1.00 45.84  ? 116 TYR R CE2 1 
ATOM   671  C CZ  . TYR A 1 254 ? 129.999 135.089 123.998 1.00 51.10  ? 116 TYR R CZ  1 
ATOM   672  O OH  . TYR A 1 254 ? 128.943 135.146 124.876 1.00 57.44  ? 116 TYR R OH  1 
ATOM   673  N N   . THR A 1 255 ? 133.999 132.064 122.321 1.00 47.27  ? 117 THR R N   1 
ATOM   674  C CA  . THR A 1 255 ? 133.702 130.942 123.209 1.00 37.01  ? 117 THR R CA  1 
ATOM   675  C C   . THR A 1 255 ? 134.924 130.542 124.030 1.00 31.16  ? 117 THR R C   1 
ATOM   676  O O   . THR A 1 255 ? 134.816 130.285 125.240 1.00 43.68  ? 117 THR R O   1 
ATOM   677  C CB  . THR A 1 255 ? 133.185 129.754 122.402 1.00 37.26  ? 117 THR R CB  1 
ATOM   678  O OG1 . THR A 1 255 ? 131.882 130.056 121.890 1.00 39.77  ? 117 THR R OG1 1 
ATOM   679  C CG2 . THR A 1 255 ? 133.092 128.518 123.275 1.00 39.74  ? 117 THR R CG2 1 
ATOM   680  N N   . VAL A 1 256 ? 136.098 130.489 123.391 1.00 25.40  ? 118 VAL R N   1 
ATOM   681  C CA  . VAL A 1 256 ? 137.319 130.125 124.107 1.00 29.01  ? 118 VAL R CA  1 
ATOM   682  C C   . VAL A 1 256 ? 137.577 131.106 125.240 1.00 28.05  ? 118 VAL R C   1 
ATOM   683  O O   . VAL A 1 256 ? 137.855 130.706 126.376 1.00 33.70  ? 118 VAL R O   1 
ATOM   684  C CB  . VAL A 1 256 ? 138.516 130.061 123.141 1.00 33.15  ? 118 VAL R CB  1 
ATOM   685  C CG1 . VAL A 1 256 ? 139.823 130.126 123.913 1.00 30.95  ? 118 VAL R CG1 1 
ATOM   686  C CG2 . VAL A 1 256 ? 138.465 128.797 122.312 1.00 36.76  ? 118 VAL R CG2 1 
ATOM   687  N N   . ASN A 1 257 ? 137.477 132.406 124.953 1.00 33.55  ? 119 ASN R N   1 
ATOM   688  C CA  . ASN A 1 257 ? 137.737 133.411 125.978 1.00 34.67  ? 119 ASN R CA  1 
ATOM   689  C C   . ASN A 1 257 ? 136.761 133.281 127.138 1.00 41.64  ? 119 ASN R C   1 
ATOM   690  O O   . ASN A 1 257 ? 137.163 133.312 128.309 1.00 50.43  ? 119 ASN R O   1 
ATOM   691  C CB  . ASN A 1 257 ? 137.656 134.810 125.376 1.00 31.03  ? 119 ASN R CB  1 
ATOM   692  C CG  . ASN A 1 257 ? 137.540 135.883 126.430 1.00 37.12  ? 119 ASN R CG  1 
ATOM   693  O OD1 . ASN A 1 257 ? 138.484 136.140 127.175 1.00 46.77  ? 119 ASN R OD1 1 
ATOM   694  N ND2 . ASN A 1 257 ? 136.371 136.504 126.516 1.00 39.40  ? 119 ASN R ND2 1 
ATOM   695  N N   . LEU A 1 258 ? 135.471 133.126 126.831 1.00 35.02  ? 120 LEU R N   1 
ATOM   696  C CA  . LEU A 1 258 ? 134.466 133.031 127.886 1.00 36.47  ? 120 LEU R CA  1 
ATOM   697  C C   . LEU A 1 258 ? 134.743 131.850 128.809 1.00 37.18  ? 120 LEU R C   1 
ATOM   698  O O   . LEU A 1 258 ? 134.859 132.009 130.038 1.00 35.05  ? 120 LEU R O   1 
ATOM   699  C CB  . LEU A 1 258 ? 133.078 132.914 127.254 1.00 30.69  ? 120 LEU R CB  1 
ATOM   700  C CG  . LEU A 1 258 ? 131.837 132.826 128.139 1.00 40.94  ? 120 LEU R CG  1 
ATOM   701  C CD1 . LEU A 1 258 ? 130.700 133.587 127.491 1.00 42.63  ? 120 LEU R CD1 1 
ATOM   702  C CD2 . LEU A 1 258 ? 131.437 131.377 128.354 1.00 36.17  ? 120 LEU R CD2 1 
ATOM   703  N N   . TYR A 1 259 ? 134.881 130.654 128.226 1.00 41.22  ? 121 TYR R N   1 
ATOM   704  C CA  . TYR A 1 259 ? 135.033 129.460 129.050 1.00 33.14  ? 121 TYR R CA  1 
ATOM   705  C C   . TYR A 1 259 ? 136.390 129.410 129.733 1.00 36.38  ? 121 TYR R C   1 
ATOM   706  O O   . TYR A 1 259 ? 136.522 128.784 130.790 1.00 41.63  ? 121 TYR R O   1 
ATOM   707  C CB  . TYR A 1 259 ? 134.807 128.206 128.209 1.00 35.96  ? 121 TYR R CB  1 
ATOM   708  C CG  . TYR A 1 259 ? 133.348 127.902 127.976 1.00 44.11  ? 121 TYR R CG  1 
ATOM   709  C CD1 . TYR A 1 259 ? 132.452 127.872 129.034 1.00 50.35  ? 121 TYR R CD1 1 
ATOM   710  C CD2 . TYR A 1 259 ? 132.864 127.651 126.702 1.00 46.04  ? 121 TYR R CD2 1 
ATOM   711  C CE1 . TYR A 1 259 ? 131.117 127.597 128.831 1.00 51.25  ? 121 TYR R CE1 1 
ATOM   712  C CE2 . TYR A 1 259 ? 131.529 127.377 126.489 1.00 48.44  ? 121 TYR R CE2 1 
ATOM   713  C CZ  . TYR A 1 259 ? 130.661 127.351 127.557 1.00 54.75  ? 121 TYR R CZ  1 
ATOM   714  O OH  . TYR A 1 259 ? 129.329 127.076 127.352 1.00 55.74  ? 121 TYR R OH  1 
ATOM   715  N N   . SER A 1 260 ? 137.408 130.054 129.160 1.00 34.08  ? 122 SER R N   1 
ATOM   716  C CA  . SER A 1 260 ? 138.711 130.080 129.809 1.00 23.37  ? 122 SER R CA  1 
ATOM   717  C C   . SER A 1 260 ? 138.704 131.001 131.020 1.00 29.97  ? 122 SER R C   1 
ATOM   718  O O   . SER A 1 260 ? 139.201 130.634 132.091 1.00 47.25  ? 122 SER R O   1 
ATOM   719  C CB  . SER A 1 260 ? 139.782 130.511 128.810 1.00 34.76  ? 122 SER R CB  1 
ATOM   720  O OG  . SER A 1 260 ? 140.984 130.849 129.476 1.00 43.97  ? 122 SER R OG  1 
ATOM   721  N N   . SER A 1 261 ? 138.142 132.204 130.876 1.00 31.41  ? 123 SER R N   1 
ATOM   722  C CA  . SER A 1 261 ? 138.167 133.157 131.981 1.00 29.34  ? 123 SER R CA  1 
ATOM   723  C C   . SER A 1 261 ? 137.304 132.681 133.144 1.00 28.72  ? 123 SER R C   1 
ATOM   724  O O   . SER A 1 261 ? 137.735 132.717 134.312 1.00 31.95  ? 123 SER R O   1 
ATOM   725  C CB  . SER A 1 261 ? 137.710 134.532 131.496 1.00 33.11  ? 123 SER R CB  1 
ATOM   726  O OG  . SER A 1 261 ? 136.300 134.644 131.542 1.00 43.80  ? 123 SER R OG  1 
ATOM   727  N N   . VAL A 1 262 ? 136.082 132.221 132.848 1.00 34.62  ? 124 VAL R N   1 
ATOM   728  C CA  . VAL A 1 262 ? 135.165 131.861 133.925 1.00 29.73  ? 124 VAL R CA  1 
ATOM   729  C C   . VAL A 1 262 ? 135.691 130.717 134.778 1.00 31.74  ? 124 VAL R C   1 
ATOM   730  O O   . VAL A 1 262 ? 135.275 130.573 135.932 1.00 40.40  ? 124 VAL R O   1 
ATOM   731  C CB  . VAL A 1 262 ? 133.774 131.508 133.356 1.00 37.06  ? 124 VAL R CB  1 
ATOM   732  C CG1 . VAL A 1 262 ? 133.837 130.237 132.526 1.00 48.33  ? 124 VAL R CG1 1 
ATOM   733  C CG2 . VAL A 1 262 ? 132.738 131.405 134.465 1.00 28.87  ? 124 VAL R CG2 1 
ATOM   734  N N   . TRP A 1 263 ? 136.623 129.917 134.255 1.00 32.86  ? 125 TRP R N   1 
ATOM   735  C CA  . TRP A 1 263 ? 137.186 128.803 135.001 1.00 30.65  ? 125 TRP R CA  1 
ATOM   736  C C   . TRP A 1 263 ? 138.582 129.072 135.544 1.00 34.17  ? 125 TRP R C   1 
ATOM   737  O O   . TRP A 1 263 ? 138.967 128.452 136.541 1.00 48.24  ? 125 TRP R O   1 
ATOM   738  C CB  . TRP A 1 263 ? 137.217 127.542 134.127 1.00 24.22  ? 125 TRP R CB  1 
ATOM   739  C CG  . TRP A 1 263 ? 135.978 126.719 134.269 1.00 33.89  ? 125 TRP R CG  1 
ATOM   740  C CD1 . TRP A 1 263 ? 134.929 126.664 133.401 1.00 30.88  ? 125 TRP R CD1 1 
ATOM   741  C CD2 . TRP A 1 263 ? 135.650 125.843 135.352 1.00 45.98  ? 125 TRP R CD2 1 
ATOM   742  N NE1 . TRP A 1 263 ? 133.970 125.804 133.872 1.00 37.95  ? 125 TRP R NE1 1 
ATOM   743  C CE2 . TRP A 1 263 ? 134.390 125.286 135.069 1.00 42.88  ? 125 TRP R CE2 1 
ATOM   744  C CE3 . TRP A 1 263 ? 136.302 125.472 136.531 1.00 40.18  ? 125 TRP R CE3 1 
ATOM   745  C CZ2 . TRP A 1 263 ? 133.769 124.379 135.922 1.00 39.40  ? 125 TRP R CZ2 1 
ATOM   746  C CZ3 . TRP A 1 263 ? 135.684 124.573 137.375 1.00 32.95  ? 125 TRP R CZ3 1 
ATOM   747  C CH2 . TRP A 1 263 ? 134.430 124.037 137.067 1.00 34.23  ? 125 TRP R CH2 1 
ATOM   748  N N   . ILE A 1 264 ? 139.345 129.982 134.934 1.00 30.47  ? 126 ILE R N   1 
ATOM   749  C CA  . ILE A 1 264 ? 140.568 130.425 135.592 1.00 14.96  ? 126 ILE R CA  1 
ATOM   750  C C   . ILE A 1 264 ? 140.223 131.144 136.886 1.00 29.34  ? 126 ILE R C   1 
ATOM   751  O O   . ILE A 1 264 ? 140.982 131.084 137.863 1.00 44.59  ? 126 ILE R O   1 
ATOM   752  C CB  . ILE A 1 264 ? 141.412 131.302 134.651 1.00 15.65  ? 126 ILE R CB  1 
ATOM   753  C CG1 . ILE A 1 264 ? 141.955 130.463 133.497 1.00 30.73  ? 126 ILE R CG1 1 
ATOM   754  C CG2 . ILE A 1 264 ? 142.574 131.927 135.393 1.00 12.21  ? 126 ILE R CG2 1 
ATOM   755  C CD1 . ILE A 1 264 ? 142.481 131.284 132.350 1.00 29.46  ? 126 ILE R CD1 1 
ATOM   756  N N   . LEU A 1 265 ? 139.061 131.804 136.940 1.00 31.92  ? 127 LEU R N   1 
ATOM   757  C CA  . LEU A 1 265 ? 138.624 132.365 138.218 1.00 31.14  ? 127 LEU R CA  1 
ATOM   758  C C   . LEU A 1 265 ? 138.440 131.272 139.273 1.00 36.40  ? 127 LEU R C   1 
ATOM   759  O O   . LEU A 1 265 ? 138.855 131.432 140.431 1.00 38.30  ? 127 LEU R O   1 
ATOM   760  C CB  . LEU A 1 265 ? 137.335 133.160 138.031 1.00 30.35  ? 127 LEU R CB  1 
ATOM   761  C CG  . LEU A 1 265 ? 137.533 134.605 137.575 1.00 20.40  ? 127 LEU R CG  1 
ATOM   762  C CD1 . LEU A 1 265 ? 136.208 135.340 137.557 1.00 35.49  ? 127 LEU R CD1 1 
ATOM   763  C CD2 . LEU A 1 265 ? 138.529 135.314 138.473 1.00 20.36  ? 127 LEU R CD2 1 
ATOM   764  N N   . ALA A 1 266 ? 137.834 130.145 138.889 1.00 33.89  ? 128 ALA R N   1 
ATOM   765  C CA  . ALA A 1 266 ? 137.645 129.045 139.832 1.00 29.16  ? 128 ALA R CA  1 
ATOM   766  C C   . ALA A 1 266 ? 138.977 128.420 140.232 1.00 28.29  ? 128 ALA R C   1 
ATOM   767  O O   . ALA A 1 266 ? 139.136 127.958 141.367 1.00 43.09  ? 128 ALA R O   1 
ATOM   768  C CB  . ALA A 1 266 ? 136.716 127.991 139.234 1.00 20.53  ? 128 ALA R CB  1 
ATOM   769  N N   . PHE A 1 267 ? 139.940 128.384 139.310 1.00 29.28  ? 129 PHE R N   1 
ATOM   770  C CA  . PHE A 1 267 ? 141.273 127.903 139.671 1.00 29.19  ? 129 PHE R CA  1 
ATOM   771  C C   . PHE A 1 267 ? 141.946 128.833 140.676 1.00 31.83  ? 129 PHE R C   1 
ATOM   772  O O   . PHE A 1 267 ? 142.634 128.368 141.592 1.00 44.72  ? 129 PHE R O   1 
ATOM   773  C CB  . PHE A 1 267 ? 142.141 127.734 138.427 1.00 35.91  ? 129 PHE R CB  1 
ATOM   774  C CG  . PHE A 1 267 ? 142.175 126.328 137.905 1.00 38.58  ? 129 PHE R CG  1 
ATOM   775  C CD1 . PHE A 1 267 ? 141.005 125.670 137.573 1.00 38.25  ? 129 PHE R CD1 1 
ATOM   776  C CD2 . PHE A 1 267 ? 143.376 125.656 137.773 1.00 36.68  ? 129 PHE R CD2 1 
ATOM   777  C CE1 . PHE A 1 267 ? 141.033 124.374 137.101 1.00 43.97  ? 129 PHE R CE1 1 
ATOM   778  C CE2 . PHE A 1 267 ? 143.411 124.359 137.303 1.00 36.60  ? 129 PHE R CE2 1 
ATOM   779  C CZ  . PHE A 1 267 ? 142.238 123.717 136.967 1.00 46.51  ? 129 PHE R CZ  1 
ATOM   780  N N   . ILE A 1 268 ? 141.757 130.146 140.526 1.00 34.69  ? 130 ILE R N   1 
ATOM   781  C CA  . ILE A 1 268 ? 142.251 131.088 141.531 1.00 39.16  ? 130 ILE R CA  1 
ATOM   782  C C   . ILE A 1 268 ? 141.614 130.798 142.885 1.00 46.18  ? 130 ILE R C   1 
ATOM   783  O O   . ILE A 1 268 ? 142.287 130.794 143.926 1.00 47.46  ? 130 ILE R O   1 
ATOM   784  C CB  . ILE A 1 268 ? 141.983 132.540 141.094 1.00 30.26  ? 130 ILE R CB  1 
ATOM   785  C CG1 . ILE A 1 268 ? 142.761 132.878 139.827 1.00 37.09  ? 130 ILE R CG1 1 
ATOM   786  C CG2 . ILE A 1 268 ? 142.337 133.508 142.207 1.00 31.33  ? 130 ILE R CG2 1 
ATOM   787  C CD1 . ILE A 1 268 ? 142.362 134.194 139.204 1.00 42.23  ? 130 ILE R CD1 1 
ATOM   788  N N   . SER A 1 269 ? 140.300 130.566 142.889 1.00 39.96  ? 131 SER R N   1 
ATOM   789  C CA  . SER A 1 269 ? 139.606 130.281 144.143 1.00 31.53  ? 131 SER R CA  1 
ATOM   790  C C   . SER A 1 269 ? 140.139 129.012 144.801 1.00 24.97  ? 131 SER R C   1 
ATOM   791  O O   . SER A 1 269 ? 140.358 128.982 146.018 1.00 37.21  ? 131 SER R O   1 
ATOM   792  C CB  . SER A 1 269 ? 138.105 130.166 143.896 1.00 41.17  ? 131 SER R CB  1 
ATOM   793  O OG  . SER A 1 269 ? 137.586 131.386 143.402 1.00 49.34  ? 131 SER R OG  1 
ATOM   794  N N   . LEU A 1 270 ? 140.346 127.953 144.014 1.00 25.47  ? 132 LEU R N   1 
ATOM   795  C CA  . LEU A 1 270 ? 140.897 126.719 144.568 1.00 33.86  ? 132 LEU R CA  1 
ATOM   796  C C   . LEU A 1 270 ? 142.308 126.930 145.100 1.00 38.24  ? 132 LEU R C   1 
ATOM   797  O O   . LEU A 1 270 ? 142.669 126.384 146.150 1.00 48.99  ? 132 LEU R O   1 
ATOM   798  C CB  . LEU A 1 270 ? 140.886 125.611 143.515 1.00 33.75  ? 132 LEU R CB  1 
ATOM   799  C CG  . LEU A 1 270 ? 139.548 124.911 143.279 1.00 36.81  ? 132 LEU R CG  1 
ATOM   800  C CD1 . LEU A 1 270 ? 139.610 124.036 142.039 1.00 38.64  ? 132 LEU R CD1 1 
ATOM   801  C CD2 . LEU A 1 270 ? 139.170 124.086 144.497 1.00 39.49  ? 132 LEU R CD2 1 
ATOM   802  N N   . ASP A 1 271 ? 143.123 127.709 144.387 1.00 39.40  ? 133 ASP R N   1 
ATOM   803  C CA  . ASP A 1 271 ? 144.467 128.004 144.869 1.00 35.10  ? 133 ASP R CA  1 
ATOM   804  C C   . ASP A 1 271 ? 144.418 128.693 146.224 1.00 40.59  ? 133 ASP R C   1 
ATOM   805  O O   . ASP A 1 271 ? 145.158 128.326 147.143 1.00 47.14  ? 133 ASP R O   1 
ATOM   806  C CB  . ASP A 1 271 ? 145.209 128.872 143.854 1.00 46.23  ? 133 ASP R CB  1 
ATOM   807  C CG  . ASP A 1 271 ? 146.691 128.972 144.144 1.00 49.53  ? 133 ASP R CG  1 
ATOM   808  O OD1 . ASP A 1 271 ? 147.448 128.092 143.684 1.00 52.98  ? 133 ASP R OD1 1 
ATOM   809  O OD2 . ASP A 1 271 ? 147.100 129.931 144.831 1.00 47.71  ? 133 ASP R OD2 1 
ATOM   810  N N   . ARG A 1 272 ? 143.534 129.682 146.371 1.00 55.28  ? 134 ARG R N   1 
ATOM   811  C CA  . ARG A 1 272 ? 143.427 130.390 147.644 1.00 54.36  ? 134 ARG R CA  1 
ATOM   812  C C   . ARG A 1 272 ? 142.921 129.474 148.753 1.00 51.12  ? 134 ARG R C   1 
ATOM   813  O O   . ARG A 1 272 ? 143.398 129.545 149.893 1.00 41.97  ? 134 ARG R O   1 
ATOM   814  C CB  . ARG A 1 272 ? 142.519 131.609 147.492 1.00 41.07  ? 134 ARG R CB  1 
ATOM   815  C CG  . ARG A 1 272 ? 143.229 132.826 146.935 1.00 37.51  ? 134 ARG R CG  1 
ATOM   816  C CD  . ARG A 1 272 ? 144.233 133.371 147.933 1.00 45.06  ? 134 ARG R CD  1 
ATOM   817  N NE  . ARG A 1 272 ? 145.587 132.898 147.673 1.00 42.92  ? 134 ARG R NE  1 
ATOM   818  C CZ  . ARG A 1 272 ? 146.538 132.814 148.593 1.00 51.51  ? 134 ARG R CZ  1 
ATOM   819  N NH1 . ARG A 1 272 ? 146.317 133.162 149.849 1.00 58.05  ? 134 ARG R NH1 1 
ATOM   820  N NH2 . ARG A 1 272 ? 147.741 132.370 148.243 1.00 49.81  ? 134 ARG R NH2 1 
ATOM   821  N N   . TYR A 1 273 ? 141.950 128.611 148.442 1.00 49.96  ? 135 TYR R N   1 
ATOM   822  C CA  . TYR A 1 273 ? 141.436 127.694 149.456 1.00 36.42  ? 135 TYR R CA  1 
ATOM   823  C C   . TYR A 1 273 ? 142.522 126.745 149.942 1.00 43.06  ? 135 TYR R C   1 
ATOM   824  O O   . TYR A 1 273 ? 142.669 126.526 151.150 1.00 65.36  ? 135 TYR R O   1 
ATOM   825  C CB  . TYR A 1 273 ? 140.246 126.906 148.909 1.00 46.60  ? 135 TYR R CB  1 
ATOM   826  C CG  . TYR A 1 273 ? 139.888 125.685 149.729 1.00 39.32  ? 135 TYR R CG  1 
ATOM   827  C CD1 . TYR A 1 273 ? 139.029 125.782 150.811 1.00 51.83  ? 135 TYR R CD1 1 
ATOM   828  C CD2 . TYR A 1 273 ? 140.401 124.434 149.415 1.00 44.29  ? 135 TYR R CD2 1 
ATOM   829  C CE1 . TYR A 1 273 ? 138.695 124.672 151.562 1.00 56.44  ? 135 TYR R CE1 1 
ATOM   830  C CE2 . TYR A 1 273 ? 140.077 123.320 150.162 1.00 53.90  ? 135 TYR R CE2 1 
ATOM   831  C CZ  . TYR A 1 273 ? 139.223 123.444 151.233 1.00 55.34  ? 135 TYR R CZ  1 
ATOM   832  O OH  . TYR A 1 273 ? 138.893 122.336 151.979 1.00 51.01  ? 135 TYR R OH  1 
ATOM   833  N N   . LEU A 1 274 ? 143.292 126.164 149.017 1.00 46.63  ? 136 LEU R N   1 
ATOM   834  C CA  . LEU A 1 274 ? 144.390 125.294 149.428 1.00 49.04  ? 136 LEU R CA  1 
ATOM   835  C C   . LEU A 1 274 ? 145.449 126.066 150.203 1.00 47.74  ? 136 LEU R C   1 
ATOM   836  O O   . LEU A 1 274 ? 146.037 125.539 151.153 1.00 46.87  ? 136 LEU R O   1 
ATOM   837  C CB  . LEU A 1 274 ? 145.016 124.597 148.218 1.00 41.80  ? 136 LEU R CB  1 
ATOM   838  C CG  . LEU A 1 274 ? 144.395 123.295 147.699 1.00 43.93  ? 136 LEU R CG  1 
ATOM   839  C CD1 . LEU A 1 274 ? 144.500 122.209 148.757 1.00 45.71  ? 136 LEU R CD1 1 
ATOM   840  C CD2 . LEU A 1 274 ? 142.956 123.457 147.249 1.00 50.24  ? 136 LEU R CD2 1 
ATOM   841  N N   . ALA A 1 275 ? 145.714 127.313 149.810 1.00 48.88  ? 137 ALA R N   1 
ATOM   842  C CA  . ALA A 1 275 ? 146.730 128.097 150.503 1.00 48.82  ? 137 ALA R CA  1 
ATOM   843  C C   . ALA A 1 275 ? 146.325 128.394 151.940 1.00 49.49  ? 137 ALA R C   1 
ATOM   844  O O   . ALA A 1 275 ? 147.160 128.334 152.849 1.00 55.14  ? 137 ALA R O   1 
ATOM   845  C CB  . ALA A 1 275 ? 147.000 129.394 149.744 1.00 54.61  ? 137 ALA R CB  1 
ATOM   846  N N   . ILE A 1 276 ? 145.056 128.716 152.168 1.00 50.09  ? 138 ILE R N   1 
ATOM   847  C CA  . ILE A 1 276 ? 144.624 129.164 153.490 1.00 48.65  ? 138 ILE R CA  1 
ATOM   848  C C   . ILE A 1 276 ? 144.241 127.993 154.388 1.00 43.58  ? 138 ILE R C   1 
ATOM   849  O O   . ILE A 1 276 ? 144.740 127.873 155.510 1.00 39.07  ? 138 ILE R O   1 
ATOM   850  C CB  . ILE A 1 276 ? 143.466 130.176 153.355 1.00 43.37  ? 138 ILE R CB  1 
ATOM   851  C CG1 . ILE A 1 276 ? 144.015 131.564 153.027 1.00 42.43  ? 138 ILE R CG1 1 
ATOM   852  C CG2 . ILE A 1 276 ? 142.646 130.227 154.633 1.00 44.33  ? 138 ILE R CG2 1 
ATOM   853  C CD1 . ILE A 1 276 ? 142.951 132.621 152.870 1.00 41.39  ? 138 ILE R CD1 1 
ATOM   854  N N   . VAL A 1 277 ? 143.351 127.113 153.922 1.00 52.51  ? 139 VAL R N   1 
ATOM   855  C CA  . VAL A 1 277 ? 142.790 126.093 154.804 1.00 44.90  ? 139 VAL R CA  1 
ATOM   856  C C   . VAL A 1 277 ? 143.845 125.058 155.181 1.00 50.40  ? 139 VAL R C   1 
ATOM   857  O O   . VAL A 1 277 ? 143.998 124.707 156.357 1.00 65.13  ? 139 VAL R O   1 
ATOM   858  C CB  . VAL A 1 277 ? 141.560 125.439 154.152 1.00 46.47  ? 139 VAL R CB  1 
ATOM   859  C CG1 . VAL A 1 277 ? 141.110 124.238 154.960 1.00 48.30  ? 139 VAL R CG1 1 
ATOM   860  C CG2 . VAL A 1 277 ? 140.441 126.452 154.034 1.00 52.98  ? 139 VAL R CG2 1 
ATOM   861  N N   . HIS A 1 278 ? 144.586 124.556 154.201 1.00 53.03  ? 140 HIS R N   1 
ATOM   862  C CA  . HIS A 1 278 ? 145.650 123.582 154.440 1.00 60.61  ? 140 HIS R CA  1 
ATOM   863  C C   . HIS A 1 278 ? 146.975 124.283 154.159 1.00 67.28  ? 140 HIS R C   1 
ATOM   864  O O   . HIS A 1 278 ? 147.529 124.171 153.067 1.00 75.06  ? 140 HIS R O   1 
ATOM   865  C CB  . HIS A 1 278 ? 145.477 122.347 153.562 1.00 61.76  ? 140 HIS R CB  1 
ATOM   866  C CG  . HIS A 1 278 ? 144.079 121.813 153.534 1.00 67.51  ? 140 HIS R CG  1 
ATOM   867  N ND1 . HIS A 1 278 ? 143.607 120.909 154.460 1.00 65.70  ? 140 HIS R ND1 1 
ATOM   868  C CD2 . HIS A 1 278 ? 143.050 122.053 152.686 1.00 68.14  ? 140 HIS R CD2 1 
ATOM   869  C CE1 . HIS A 1 278 ? 142.349 120.616 154.186 1.00 67.22  ? 140 HIS R CE1 1 
ATOM   870  N NE2 . HIS A 1 278 ? 141.986 121.298 153.115 1.00 70.00  ? 140 HIS R NE2 1 
ATOM   871  N N   . ALA A 1 279 ? 147.495 124.987 155.163 1.00 68.21  ? 141 ALA R N   1 
ATOM   872  C CA  . ALA A 1 279 ? 148.650 125.857 154.988 1.00 67.26  ? 141 ALA R CA  1 
ATOM   873  C C   . ALA A 1 279 ? 149.971 125.179 155.327 1.00 63.58  ? 141 ALA R C   1 
ATOM   874  O O   . ALA A 1 279 ? 151.025 125.809 155.207 1.00 59.46  ? 141 ALA R O   1 
ATOM   875  C CB  . ALA A 1 279 ? 148.487 127.123 155.831 1.00 61.03  ? 141 ALA R CB  1 
ATOM   876  N N   . THR A 1 280 ? 149.944 123.914 155.742 1.00 80.22  ? 142 THR R N   1 
ATOM   877  C CA  . THR A 1 280 ? 151.167 123.231 156.146 1.00 81.03  ? 142 THR R CA  1 
ATOM   878  C C   . THR A 1 280 ? 151.880 122.578 154.966 1.00 79.03  ? 142 THR R C   1 
ATOM   879  O O   . THR A 1 280 ? 153.090 122.753 154.797 1.00 80.02  ? 142 THR R O   1 
ATOM   880  C CB  . THR A 1 280 ? 150.856 122.179 157.215 1.00 82.48  ? 142 THR R CB  1 
ATOM   881  O OG1 . THR A 1 280 ? 150.083 121.120 156.636 1.00 82.75  ? 142 THR R OG1 1 
ATOM   882  C CG2 . THR A 1 280 ? 150.075 122.802 158.362 1.00 81.17  ? 142 THR R CG2 1 
ATOM   883  N N   . ASN A 1 281 ? 151.150 121.828 154.146 1.00 79.13  ? 143 ASN R N   1 
ATOM   884  C CA  . ASN A 1 281 ? 151.725 121.072 153.037 1.00 80.46  ? 143 ASN R CA  1 
ATOM   885  C C   . ASN A 1 281 ? 150.961 121.345 151.748 1.00 77.04  ? 143 ASN R C   1 
ATOM   886  O O   . ASN A 1 281 ? 150.589 120.431 151.009 1.00 78.30  ? 143 ASN R O   1 
ATOM   887  C CB  . ASN A 1 281 ? 151.739 119.580 153.354 1.00 82.99  ? 143 ASN R CB  1 
ATOM   888  C CG  . ASN A 1 281 ? 150.420 119.095 153.923 1.00 83.32  ? 143 ASN R CG  1 
ATOM   889  O OD1 . ASN A 1 281 ? 149.498 119.880 154.142 1.00 81.85  ? 143 ASN R OD1 1 
ATOM   890  N ND2 . ASN A 1 281 ? 150.324 117.793 154.166 1.00 80.42  ? 143 ASN R ND2 1 
ATOM   891  N N   . SER A 1 282 ? 150.708 122.620 151.463 1.00 76.41  ? 144 SER R N   1 
ATOM   892  C CA  . SER A 1 282 ? 150.032 123.015 150.236 1.00 78.92  ? 144 SER R CA  1 
ATOM   893  C C   . SER A 1 282 ? 150.992 123.336 149.102 1.00 79.84  ? 144 SER R C   1 
ATOM   894  O O   . SER A 1 282 ? 150.537 123.599 147.984 1.00 83.44  ? 144 SER R O   1 
ATOM   895  C CB  . SER A 1 282 ? 149.139 124.231 150.485 1.00 79.37  ? 144 SER R CB  1 
ATOM   896  O OG  . SER A 1 282 ? 149.905 125.422 150.528 1.00 76.99  ? 144 SER R OG  1 
ATOM   897  N N   . GLN A 1 283 ? 152.302 123.326 149.356 1.00 75.81  ? 145 GLN R N   1 
ATOM   898  C CA  . GLN A 1 283 ? 153.245 123.732 148.321 1.00 76.16  ? 145 GLN R CA  1 
ATOM   899  C C   . GLN A 1 283 ? 153.178 122.804 147.116 1.00 77.38  ? 145 GLN R C   1 
ATOM   900  O O   . GLN A 1 283 ? 153.156 123.268 145.971 1.00 80.03  ? 145 GLN R O   1 
ATOM   901  C CB  . GLN A 1 283 ? 154.662 123.785 148.886 1.00 78.30  ? 145 GLN R CB  1 
ATOM   902  C CG  . GLN A 1 283 ? 155.073 125.168 149.366 1.00 79.44  ? 145 GLN R CG  1 
ATOM   903  C CD  . GLN A 1 283 ? 154.952 126.226 148.284 1.00 81.40  ? 145 GLN R CD  1 
ATOM   904  O OE1 . GLN A 1 283 ? 155.157 125.950 147.101 1.00 83.46  ? 145 GLN R OE1 1 
ATOM   905  N NE2 . GLN A 1 283 ? 154.613 127.445 148.686 1.00 77.81  ? 145 GLN R NE2 1 
ATOM   906  N N   . ARG A 1 284 ? 153.112 121.490 147.348 1.00 73.89  ? 146 ARG R N   1 
ATOM   907  C CA  . ARG A 1 284 ? 153.051 120.569 146.214 1.00 74.43  ? 146 ARG R CA  1 
ATOM   908  C C   . ARG A 1 284 ? 151.707 120.641 145.495 1.00 74.53  ? 146 ARG R C   1 
ATOM   909  O O   . ARG A 1 284 ? 151.703 120.799 144.259 1.00 77.98  ? 146 ARG R O   1 
ATOM   910  C CB  . ARG A 1 284 ? 153.401 119.149 146.674 1.00 73.48  ? 146 ARG R CB  1 
ATOM   911  C CG  . ARG A 1 284 ? 154.173 118.331 145.658 1.00 74.42  ? 146 ARG R CG  1 
ATOM   912  C CD  . ARG A 1 284 ? 155.669 118.541 145.813 1.00 77.66  ? 146 ARG R CD  1 
ATOM   913  N NE  . ARG A 1 284 ? 156.437 117.636 144.967 1.00 82.87  ? 146 ARG R NE  1 
ATOM   914  C CZ  . ARG A 1 284 ? 157.747 117.719 144.778 1.00 81.76  ? 146 ARG R CZ  1 
ATOM   915  N NH1 . ARG A 1 284 ? 158.471 118.660 145.362 1.00 77.66  ? 146 ARG R NH1 1 
ATOM   916  N NH2 . ARG A 1 284 ? 158.346 116.836 143.984 1.00 79.77  ? 146 ARG R NH2 1 
ATOM   917  N N   . PRO A 1 285 ? 150.534 120.520 146.172 1.00 60.62  ? 147 PRO R N   1 
ATOM   918  C CA  . PRO A 1 285 ? 149.275 120.751 145.451 1.00 56.43  ? 147 PRO R CA  1 
ATOM   919  C C   . PRO A 1 285 ? 148.912 122.224 145.399 1.00 62.15  ? 147 PRO R C   1 
ATOM   920  O O   . PRO A 1 285 ? 147.745 122.598 145.546 1.00 62.32  ? 147 PRO R O   1 
ATOM   921  C CB  . PRO A 1 285 ? 148.245 119.968 146.275 1.00 57.88  ? 147 PRO R CB  1 
ATOM   922  C CG  . PRO A 1 285 ? 149.041 119.050 147.138 1.00 64.81  ? 147 PRO R CG  1 
ATOM   923  C CD  . PRO A 1 285 ? 150.283 119.821 147.442 1.00 65.94  ? 147 PRO R CD  1 
ATOM   924  N N   . ARG A 1 286 ? 149.918 123.068 145.189 1.00 70.99  ? 148 ARG R N   1 
ATOM   925  C CA  . ARG A 1 286 ? 149.725 124.477 144.880 1.00 69.64  ? 148 ARG R CA  1 
ATOM   926  C C   . ARG A 1 286 ? 150.643 124.823 143.719 1.00 65.20  ? 148 ARG R C   1 
ATOM   927  O O   . ARG A 1 286 ? 150.379 125.751 142.949 1.00 65.57  ? 148 ARG R O   1 
ATOM   928  C CB  . ARG A 1 286 ? 150.021 125.347 146.102 1.00 67.97  ? 148 ARG R CB  1 
ATOM   929  C CG  . ARG A 1 286 ? 149.595 126.792 145.961 1.00 66.25  ? 148 ARG R CG  1 
ATOM   930  C CD  . ARG A 1 286 ? 149.529 127.476 147.311 1.00 61.42  ? 148 ARG R CD  1 
ATOM   931  N NE  . ARG A 1 286 ? 149.339 128.914 147.173 1.00 62.76  ? 148 ARG R NE  1 
ATOM   932  C CZ  . ARG A 1 286 ? 150.323 129.780 146.979 1.00 69.56  ? 148 ARG R CZ  1 
ATOM   933  N NH1 . ARG A 1 286 ? 151.584 129.388 146.900 1.00 73.36  ? 148 ARG R NH1 1 
ATOM   934  N NH2 . ARG A 1 286 ? 150.035 131.073 146.860 1.00 69.21  ? 148 ARG R NH2 1 
ATOM   935  N N   . LYS A 1 287 ? 151.730 124.065 143.599 1.00 53.81  ? 149 LYS R N   1 
ATOM   936  C CA  . LYS A 1 287 ? 152.660 124.188 142.490 1.00 53.61  ? 149 LYS R CA  1 
ATOM   937  C C   . LYS A 1 287 ? 152.259 123.300 141.320 1.00 56.77  ? 149 LYS R C   1 
ATOM   938  O O   . LYS A 1 287 ? 152.250 123.757 140.174 1.00 68.83  ? 149 LYS R O   1 
ATOM   939  C CB  . LYS A 1 287 ? 154.076 123.844 142.959 1.00 61.68  ? 149 LYS R CB  1 
ATOM   940  C CG  . LYS A 1 287 ? 155.087 123.693 141.838 1.00 61.93  ? 149 LYS R CG  1 
ATOM   941  C CD  . LYS A 1 287 ? 156.491 123.505 142.388 1.00 66.15  ? 149 LYS R CD  1 
ATOM   942  C CE  . LYS A 1 287 ? 157.401 122.843 141.366 1.00 65.64  ? 149 LYS R CE  1 
ATOM   943  N NZ  . LYS A 1 287 ? 157.180 121.372 141.295 1.00 63.53  ? 149 LYS R NZ  1 
ATOM   944  N N   . LEU A 1 288 ? 151.931 122.031 141.585 1.00 52.07  ? 150 LEU R N   1 
ATOM   945  C CA  . LEU A 1 288 ? 151.551 121.137 140.494 1.00 56.74  ? 150 LEU R CA  1 
ATOM   946  C C   . LEU A 1 288 ? 150.255 121.587 139.832 1.00 55.25  ? 150 LEU R C   1 
ATOM   947  O O   . LEU A 1 288 ? 150.157 121.606 138.599 1.00 64.86  ? 150 LEU R O   1 
ATOM   948  C CB  . LEU A 1 288 ? 151.421 119.703 141.006 1.00 58.13  ? 150 LEU R CB  1 
ATOM   949  C CG  . LEU A 1 288 ? 152.666 118.816 140.920 1.00 60.98  ? 150 LEU R CG  1 
ATOM   950  C CD1 . LEU A 1 288 ? 153.084 118.630 139.470 1.00 59.66  ? 150 LEU R CD1 1 
ATOM   951  C CD2 . LEU A 1 288 ? 153.814 119.378 141.745 1.00 58.64  ? 150 LEU R CD2 1 
ATOM   952  N N   . LEU A 1 289 ? 149.263 121.979 140.635 1.00 40.94  ? 151 LEU R N   1 
ATOM   953  C CA  . LEU A 1 289 ? 147.954 122.350 140.111 1.00 34.37  ? 151 LEU R CA  1 
ATOM   954  C C   . LEU A 1 289 ? 148.020 123.551 139.176 1.00 46.71  ? 151 LEU R C   1 
ATOM   955  O O   . LEU A 1 289 ? 147.099 123.751 138.377 1.00 51.13  ? 151 LEU R O   1 
ATOM   956  C CB  . LEU A 1 289 ? 146.998 122.632 141.274 1.00 41.47  ? 151 LEU R CB  1 
ATOM   957  C CG  . LEU A 1 289 ? 145.527 122.943 140.994 1.00 48.09  ? 151 LEU R CG  1 
ATOM   958  C CD1 . LEU A 1 289 ? 144.636 122.215 141.982 1.00 44.92  ? 151 LEU R CD1 1 
ATOM   959  C CD2 . LEU A 1 289 ? 145.274 124.439 141.061 1.00 52.07  ? 151 LEU R CD2 1 
ATOM   960  N N   . ALA A 1 290 ? 149.086 124.351 139.250 1.00 46.29  ? 152 ALA R N   1 
ATOM   961  C CA  . ALA A 1 290 ? 149.268 125.480 138.351 1.00 37.42  ? 152 ALA R CA  1 
ATOM   962  C C   . ALA A 1 290 ? 150.341 125.259 137.299 1.00 36.72  ? 152 ALA R C   1 
ATOM   963  O O   . ALA A 1 290 ? 150.334 125.958 136.282 1.00 44.21  ? 152 ALA R O   1 
ATOM   964  C CB  . ALA A 1 290 ? 149.618 126.747 139.144 1.00 36.47  ? 152 ALA R CB  1 
ATOM   965  N N   . GLU A 1 291 ? 151.260 124.321 137.514 1.00 41.29  ? 153 GLU R N   1 
ATOM   966  C CA  . GLU A 1 291 ? 152.341 124.085 136.569 1.00 42.70  ? 153 GLU R CA  1 
ATOM   967  C C   . GLU A 1 291 ? 152.027 123.008 135.543 1.00 47.62  ? 153 GLU R C   1 
ATOM   968  O O   . GLU A 1 291 ? 152.574 123.051 134.437 1.00 59.52  ? 153 GLU R O   1 
ATOM   969  C CB  . GLU A 1 291 ? 153.620 123.702 137.319 1.00 55.39  ? 153 GLU R CB  1 
ATOM   970  C CG  . GLU A 1 291 ? 154.337 124.880 137.959 1.00 60.86  ? 153 GLU R CG  1 
ATOM   971  C CD  . GLU A 1 291 ? 155.725 124.523 138.451 1.00 59.60  ? 153 GLU R CD  1 
ATOM   972  O OE1 . GLU A 1 291 ? 156.114 123.342 138.331 1.00 55.32  ? 153 GLU R OE1 1 
ATOM   973  O OE2 . GLU A 1 291 ? 156.426 125.422 138.960 1.00 56.19  ? 153 GLU R OE2 1 
ATOM   974  N N   . LYS A 1 292 ? 151.168 122.041 135.872 1.00 52.10  ? 154 LYS R N   1 
ATOM   975  C CA  . LYS A 1 292 ? 150.862 120.972 134.932 1.00 52.87  ? 154 LYS R CA  1 
ATOM   976  C C   . LYS A 1 292 ? 149.381 120.641 134.835 1.00 51.69  ? 154 LYS R C   1 
ATOM   977  O O   . LYS A 1 292 ? 149.027 119.712 134.105 1.00 55.82  ? 154 LYS R O   1 
ATOM   978  C CB  . LYS A 1 292 ? 151.633 119.694 135.304 1.00 51.36  ? 154 LYS R CB  1 
ATOM   979  C CG  . LYS A 1 292 ? 153.138 119.788 135.128 1.00 52.98  ? 154 LYS R CG  1 
ATOM   980  C CD  . LYS A 1 292 ? 153.782 118.414 135.206 1.00 59.05  ? 154 LYS R CD  1 
ATOM   981  C CE  . LYS A 1 292 ? 155.260 118.512 135.549 1.00 58.68  ? 154 LYS R CE  1 
ATOM   982  N NZ  . LYS A 1 292 ? 155.481 119.107 136.895 1.00 58.59  ? 154 LYS R NZ  1 
ATOM   983  N N   . VAL A 1 293 ? 148.509 121.357 135.538 1.00 44.36  ? 155 VAL R N   1 
ATOM   984  C CA  . VAL A 1 293 ? 147.096 121.008 135.577 1.00 35.88  ? 155 VAL R CA  1 
ATOM   985  C C   . VAL A 1 293 ? 146.193 122.130 135.082 1.00 42.85  ? 155 VAL R C   1 
ATOM   986  O O   . VAL A 1 293 ? 145.055 121.849 134.674 1.00 48.90  ? 155 VAL R O   1 
ATOM   987  C CB  . VAL A 1 293 ? 146.679 120.572 137.000 1.00 44.34  ? 155 VAL R CB  1 
ATOM   988  C CG1 . VAL A 1 293 ? 145.256 120.025 137.023 1.00 45.05  ? 155 VAL R CG1 1 
ATOM   989  C CG2 . VAL A 1 293 ? 147.651 119.537 137.546 1.00 48.23  ? 155 VAL R CG2 1 
ATOM   990  N N   . VAL A 1 294 ? 146.648 123.386 135.075 1.00 40.46  ? 156 VAL R N   1 
ATOM   991  C CA  . VAL A 1 294 ? 145.787 124.480 134.630 1.00 37.23  ? 156 VAL R CA  1 
ATOM   992  C C   . VAL A 1 294 ? 145.445 124.327 133.154 1.00 43.10  ? 156 VAL R C   1 
ATOM   993  O O   . VAL A 1 294 ? 144.302 124.562 132.742 1.00 51.88  ? 156 VAL R O   1 
ATOM   994  C CB  . VAL A 1 294 ? 146.439 125.843 134.930 1.00 38.67  ? 156 VAL R CB  1 
ATOM   995  C CG1 . VAL A 1 294 ? 147.790 125.964 134.253 1.00 40.81  ? 156 VAL R CG1 1 
ATOM   996  C CG2 . VAL A 1 294 ? 145.525 126.973 134.490 1.00 32.53  ? 156 VAL R CG2 1 
ATOM   997  N N   . TYR A 1 295 ? 146.418 123.915 132.337 1.00 47.55  ? 157 TYR R N   1 
ATOM   998  C CA  . TYR A 1 295 ? 146.160 123.727 130.913 1.00 49.17  ? 157 TYR R CA  1 
ATOM   999  C C   . TYR A 1 295 ? 145.068 122.690 130.689 1.00 43.27  ? 157 TYR R C   1 
ATOM   1000 O O   . TYR A 1 295 ? 144.061 122.970 130.031 1.00 32.23  ? 157 TYR R O   1 
ATOM   1001 C CB  . TYR A 1 295 ? 147.448 123.319 130.200 1.00 44.01  ? 157 TYR R CB  1 
ATOM   1002 C CG  . TYR A 1 295 ? 148.622 124.203 130.537 1.00 48.42  ? 157 TYR R CG  1 
ATOM   1003 C CD1 . TYR A 1 295 ? 148.744 125.469 129.982 1.00 43.76  ? 157 TYR R CD1 1 
ATOM   1004 C CD2 . TYR A 1 295 ? 149.604 123.778 131.418 1.00 47.78  ? 157 TYR R CD2 1 
ATOM   1005 C CE1 . TYR A 1 295 ? 149.815 126.284 130.291 1.00 43.24  ? 157 TYR R CE1 1 
ATOM   1006 C CE2 . TYR A 1 295 ? 150.679 124.585 131.733 1.00 52.43  ? 157 TYR R CE2 1 
ATOM   1007 C CZ  . TYR A 1 295 ? 150.779 125.837 131.167 1.00 50.67  ? 157 TYR R CZ  1 
ATOM   1008 O OH  . TYR A 1 295 ? 151.849 126.643 131.480 1.00 52.39  ? 157 TYR R OH  1 
ATOM   1009 N N   . VAL A 1 296 ? 145.226 121.508 131.288 1.00 51.71  ? 158 VAL R N   1 
ATOM   1010 C CA  . VAL A 1 296 ? 144.260 120.430 131.102 1.00 41.50  ? 158 VAL R CA  1 
ATOM   1011 C C   . VAL A 1 296 ? 142.900 120.824 131.662 1.00 44.84  ? 158 VAL R C   1 
ATOM   1012 O O   . VAL A 1 296 ? 141.858 120.505 131.079 1.00 52.23  ? 158 VAL R O   1 
ATOM   1013 C CB  . VAL A 1 296 ? 144.786 119.133 131.743 1.00 44.20  ? 158 VAL R CB  1 
ATOM   1014 C CG1 . VAL A 1 296 ? 143.670 118.112 131.890 1.00 42.31  ? 158 VAL R CG1 1 
ATOM   1015 C CG2 . VAL A 1 296 ? 145.929 118.562 130.919 1.00 46.01  ? 158 VAL R CG2 1 
ATOM   1016 N N   . GLY A 1 297 ? 142.881 121.526 132.797 1.00 42.49  ? 159 GLY R N   1 
ATOM   1017 C CA  . GLY A 1 297 ? 141.617 121.868 133.422 1.00 44.31  ? 159 GLY R CA  1 
ATOM   1018 C C   . GLY A 1 297 ? 140.868 123.012 132.776 1.00 49.83  ? 159 GLY R C   1 
ATOM   1019 O O   . GLY A 1 297 ? 139.646 123.096 132.933 1.00 51.96  ? 159 GLY R O   1 
ATOM   1020 N N   . VAL A 1 298 ? 141.557 123.891 132.051 1.00 47.04  ? 160 VAL R N   1 
ATOM   1021 C CA  . VAL A 1 298 ? 140.948 125.096 131.495 1.00 41.93  ? 160 VAL R CA  1 
ATOM   1022 C C   . VAL A 1 298 ? 140.941 125.071 129.968 1.00 45.37  ? 160 VAL R C   1 
ATOM   1023 O O   . VAL A 1 298 ? 139.879 125.107 129.345 1.00 49.56  ? 160 VAL R O   1 
ATOM   1024 C CB  . VAL A 1 298 ? 141.648 126.365 132.029 1.00 37.03  ? 160 VAL R CB  1 
ATOM   1025 C CG1 . VAL A 1 298 ? 141.189 127.588 131.256 1.00 41.50  ? 160 VAL R CG1 1 
ATOM   1026 C CG2 . VAL A 1 298 ? 141.378 126.530 133.513 1.00 33.86  ? 160 VAL R CG2 1 
ATOM   1027 N N   . TRP A 1 299 ? 142.120 125.013 129.347 1.00 36.89  ? 161 TRP R N   1 
ATOM   1028 C CA  . TRP A 1 299 ? 142.201 125.285 127.917 1.00 36.99  ? 161 TRP R CA  1 
ATOM   1029 C C   . TRP A 1 299 ? 141.623 124.143 127.090 1.00 51.97  ? 161 TRP R C   1 
ATOM   1030 O O   . TRP A 1 299 ? 140.867 124.383 126.141 1.00 54.76  ? 161 TRP R O   1 
ATOM   1031 C CB  . TRP A 1 299 ? 143.651 125.560 127.523 1.00 38.04  ? 161 TRP R CB  1 
ATOM   1032 C CG  . TRP A 1 299 ? 144.195 126.829 128.110 1.00 40.87  ? 161 TRP R CG  1 
ATOM   1033 C CD1 . TRP A 1 299 ? 145.152 126.940 129.075 1.00 43.90  ? 161 TRP R CD1 1 
ATOM   1034 C CD2 . TRP A 1 299 ? 143.812 128.167 127.770 1.00 43.53  ? 161 TRP R CD2 1 
ATOM   1035 N NE1 . TRP A 1 299 ? 145.389 128.263 129.357 1.00 41.95  ? 161 TRP R NE1 1 
ATOM   1036 C CE2 . TRP A 1 299 ? 144.579 129.036 128.569 1.00 36.63  ? 161 TRP R CE2 1 
ATOM   1037 C CE3 . TRP A 1 299 ? 142.897 128.714 126.867 1.00 50.69  ? 161 TRP R CE3 1 
ATOM   1038 C CZ2 . TRP A 1 299 ? 144.459 130.420 128.492 1.00 37.99  ? 161 TRP R CZ2 1 
ATOM   1039 C CZ3 . TRP A 1 299 ? 142.779 130.089 126.793 1.00 43.10  ? 161 TRP R CZ3 1 
ATOM   1040 C CH2 . TRP A 1 299 ? 143.555 130.926 127.601 1.00 38.79  ? 161 TRP R CH2 1 
ATOM   1041 N N   . ILE A 1 300 ? 141.962 122.896 127.429 1.00 51.71  ? 162 ILE R N   1 
ATOM   1042 C CA  . ILE A 1 300 ? 141.526 121.762 126.611 1.00 42.95  ? 162 ILE R CA  1 
ATOM   1043 C C   . ILE A 1 300 ? 140.007 121.625 126.568 1.00 42.46  ? 162 ILE R C   1 
ATOM   1044 O O   . ILE A 1 300 ? 139.456 121.475 125.465 1.00 48.37  ? 162 ILE R O   1 
ATOM   1045 C CB  . ILE A 1 300 ? 142.234 120.474 127.069 1.00 42.13  ? 162 ILE R CB  1 
ATOM   1046 C CG1 . ILE A 1 300 ? 143.693 120.487 126.614 1.00 40.80  ? 162 ILE R CG1 1 
ATOM   1047 C CG2 . ILE A 1 300 ? 141.519 119.250 126.532 1.00 42.08  ? 162 ILE R CG2 1 
ATOM   1048 C CD1 . ILE A 1 300 ? 144.513 119.344 127.161 1.00 46.54  ? 162 ILE R CD1 1 
ATOM   1049 N N   . PRO A 1 301 ? 139.277 121.652 127.691 1.00 42.22  ? 163 PRO R N   1 
ATOM   1050 C CA  . PRO A 1 301 ? 137.808 121.689 127.575 1.00 44.81  ? 163 PRO R CA  1 
ATOM   1051 C C   . PRO A 1 301 ? 137.304 122.920 126.844 1.00 50.07  ? 163 PRO R C   1 
ATOM   1052 O O   . PRO A 1 301 ? 136.311 122.838 126.109 1.00 47.43  ? 163 PRO R O   1 
ATOM   1053 C CB  . PRO A 1 301 ? 137.339 121.656 129.037 1.00 46.12  ? 163 PRO R CB  1 
ATOM   1054 C CG  . PRO A 1 301 ? 138.474 121.066 129.787 1.00 41.56  ? 163 PRO R CG  1 
ATOM   1055 C CD  . PRO A 1 301 ? 139.699 121.571 129.100 1.00 39.00  ? 163 PRO R CD  1 
ATOM   1056 N N   . ALA A 1 302 ? 137.971 124.064 127.019 1.00 47.43  ? 164 ALA R N   1 
ATOM   1057 C CA  . ALA A 1 302 ? 137.577 125.269 126.298 1.00 36.85  ? 164 ALA R CA  1 
ATOM   1058 C C   . ALA A 1 302 ? 137.744 125.088 124.797 1.00 46.42  ? 164 ALA R C   1 
ATOM   1059 O O   . ALA A 1 302 ? 136.877 125.495 124.015 1.00 56.98  ? 164 ALA R O   1 
ATOM   1060 C CB  . ALA A 1 302 ? 138.389 126.466 126.788 1.00 22.57  ? 164 ALA R CB  1 
ATOM   1061 N N   . LEU A 1 303 ? 138.856 124.483 124.374 1.00 47.19  ? 165 LEU R N   1 
ATOM   1062 C CA  . LEU A 1 303 ? 139.051 124.209 122.955 1.00 46.95  ? 165 LEU R CA  1 
ATOM   1063 C C   . LEU A 1 303 ? 138.027 123.205 122.441 1.00 46.32  ? 165 LEU R C   1 
ATOM   1064 O O   . LEU A 1 303 ? 137.491 123.366 121.338 1.00 57.54  ? 165 LEU R O   1 
ATOM   1065 C CB  . LEU A 1 303 ? 140.470 123.701 122.708 1.00 49.37  ? 165 LEU R CB  1 
ATOM   1066 C CG  . LEU A 1 303 ? 141.603 124.699 122.948 1.00 50.51  ? 165 LEU R CG  1 
ATOM   1067 C CD1 . LEU A 1 303 ? 142.943 124.082 122.584 1.00 49.96  ? 165 LEU R CD1 1 
ATOM   1068 C CD2 . LEU A 1 303 ? 141.368 125.979 122.166 1.00 50.61  ? 165 LEU R CD2 1 
ATOM   1069 N N   . LEU A 1 304 ? 137.739 122.166 123.226 1.00 43.03  ? 166 LEU R N   1 
ATOM   1070 C CA  . LEU A 1 304 ? 136.815 121.133 122.774 1.00 51.46  ? 166 LEU R CA  1 
ATOM   1071 C C   . LEU A 1 304 ? 135.386 121.651 122.678 1.00 52.49  ? 166 LEU R C   1 
ATOM   1072 O O   . LEU A 1 304 ? 134.609 121.166 121.848 1.00 55.15  ? 166 LEU R O   1 
ATOM   1073 C CB  . LEU A 1 304 ? 136.880 119.927 123.709 1.00 53.43  ? 166 LEU R CB  1 
ATOM   1074 C CG  . LEU A 1 304 ? 138.058 118.977 123.490 1.00 47.08  ? 166 LEU R CG  1 
ATOM   1075 C CD1 . LEU A 1 304 ? 137.968 117.785 124.428 1.00 48.40  ? 166 LEU R CD1 1 
ATOM   1076 C CD2 . LEU A 1 304 ? 138.116 118.520 122.043 1.00 47.55  ? 166 LEU R CD2 1 
ATOM   1077 N N   . LEU A 1 305 ? 135.018 122.627 123.509 1.00 52.10  ? 167 LEU R N   1 
ATOM   1078 C CA  . LEU A 1 305 ? 133.663 123.162 123.476 1.00 54.30  ? 167 LEU R CA  1 
ATOM   1079 C C   . LEU A 1 305 ? 133.383 124.006 122.240 1.00 57.57  ? 167 LEU R C   1 
ATOM   1080 O O   . LEU A 1 305 ? 132.226 124.376 122.017 1.00 65.41  ? 167 LEU R O   1 
ATOM   1081 C CB  . LEU A 1 305 ? 133.395 123.991 124.733 1.00 50.18  ? 167 LEU R CB  1 
ATOM   1082 C CG  . LEU A 1 305 ? 132.780 123.225 125.904 1.00 52.16  ? 167 LEU R CG  1 
ATOM   1083 C CD1 . LEU A 1 305 ? 132.793 124.070 127.164 1.00 53.31  ? 167 LEU R CD1 1 
ATOM   1084 C CD2 . LEU A 1 305 ? 131.366 122.788 125.564 1.00 51.35  ? 167 LEU R CD2 1 
ATOM   1085 N N   . THR A 1 306 ? 134.398 124.322 121.440 1.00 47.97  ? 168 THR R N   1 
ATOM   1086 C CA  . THR A 1 306 ? 134.223 125.162 120.264 1.00 43.68  ? 168 THR R CA  1 
ATOM   1087 C C   . THR A 1 306 ? 133.934 124.372 118.996 1.00 51.35  ? 168 THR R C   1 
ATOM   1088 O O   . THR A 1 306 ? 133.849 124.973 117.921 1.00 60.44  ? 168 THR R O   1 
ATOM   1089 C CB  . THR A 1 306 ? 135.462 126.032 120.046 1.00 42.33  ? 168 THR R CB  1 
ATOM   1090 O OG1 . THR A 1 306 ? 136.620 125.197 119.936 1.00 58.90  ? 168 THR R OG1 1 
ATOM   1091 C CG2 . THR A 1 306 ? 135.640 126.980 121.206 1.00 41.18  ? 168 THR R CG2 1 
ATOM   1092 N N   . ILE A 1 307 ? 133.803 123.048 119.085 1.00 57.69  ? 169 ILE R N   1 
ATOM   1093 C CA  . ILE A 1 307 ? 133.422 122.262 117.909 1.00 63.04  ? 169 ILE R CA  1 
ATOM   1094 C C   . ILE A 1 307 ? 132.077 122.706 117.342 1.00 60.61  ? 169 ILE R C   1 
ATOM   1095 O O   . ILE A 1 307 ? 131.962 122.833 116.110 1.00 64.96  ? 169 ILE R O   1 
ATOM   1096 C CB  . ILE A 1 307 ? 133.470 120.760 118.241 1.00 59.11  ? 169 ILE R CB  1 
ATOM   1097 C CG1 . ILE A 1 307 ? 134.916 120.263 118.231 1.00 53.94  ? 169 ILE R CG1 1 
ATOM   1098 C CG2 . ILE A 1 307 ? 132.628 119.963 117.260 1.00 57.67  ? 169 ILE R CG2 1 
ATOM   1099 C CD1 . ILE A 1 307 ? 135.095 118.898 118.853 1.00 54.15  ? 169 ILE R CD1 1 
ATOM   1100 N N   . PRO A 1 308 ? 131.038 122.955 118.147 1.00 51.11  ? 170 PRO R N   1 
ATOM   1101 C CA  . PRO A 1 308 ? 129.812 123.524 117.570 1.00 57.98  ? 170 PRO R CA  1 
ATOM   1102 C C   . PRO A 1 308 ? 130.019 124.881 116.924 1.00 68.37  ? 170 PRO R C   1 
ATOM   1103 O O   . PRO A 1 308 ? 129.263 125.237 116.014 1.00 72.31  ? 170 PRO R O   1 
ATOM   1104 C CB  . PRO A 1 308 ? 128.866 123.607 118.774 1.00 58.81  ? 170 PRO R CB  1 
ATOM   1105 C CG  . PRO A 1 308 ? 129.355 122.567 119.699 1.00 62.48  ? 170 PRO R CG  1 
ATOM   1106 C CD  . PRO A 1 308 ? 130.842 122.604 119.565 1.00 57.43  ? 170 PRO R CD  1 
ATOM   1107 N N   . ASP A 1 309 ? 131.008 125.661 117.368 1.00 64.55  ? 171 ASP R N   1 
ATOM   1108 C CA  . ASP A 1 309 ? 131.324 126.901 116.667 1.00 55.89  ? 171 ASP R CA  1 
ATOM   1109 C C   . ASP A 1 309 ? 131.820 126.618 115.257 1.00 50.50  ? 171 ASP R C   1 
ATOM   1110 O O   . ASP A 1 309 ? 131.435 127.304 114.305 1.00 55.27  ? 171 ASP R O   1 
ATOM   1111 C CB  . ASP A 1 309 ? 132.367 127.702 117.443 1.00 60.05  ? 171 ASP R CB  1 
ATOM   1112 C CG  . ASP A 1 309 ? 131.855 128.179 118.779 1.00 69.74  ? 171 ASP R CG  1 
ATOM   1113 O OD1 . ASP A 1 309 ? 130.654 128.494 118.880 1.00 68.41  ? 171 ASP R OD1 1 
ATOM   1114 O OD2 . ASP A 1 309 ? 132.656 128.234 119.732 1.00 73.63  ? 171 ASP R OD2 1 
ATOM   1115 N N   . PHE A 1 310 ? 132.681 125.611 115.106 1.00 43.23  ? 172 PHE R N   1 
ATOM   1116 C CA  . PHE A 1 310 ? 133.142 125.231 113.777 1.00 42.02  ? 172 PHE R CA  1 
ATOM   1117 C C   . PHE A 1 310 ? 131.989 124.725 112.924 1.00 50.97  ? 172 PHE R C   1 
ATOM   1118 O O   . PHE A 1 310 ? 131.904 125.035 111.730 1.00 61.58  ? 172 PHE R O   1 
ATOM   1119 C CB  . PHE A 1 310 ? 134.231 124.166 113.887 1.00 44.08  ? 172 PHE R CB  1 
ATOM   1120 C CG  . PHE A 1 310 ? 135.559 124.703 114.322 1.00 49.05  ? 172 PHE R CG  1 
ATOM   1121 C CD1 . PHE A 1 310 ? 136.386 125.353 113.425 1.00 53.46  ? 172 PHE R CD1 1 
ATOM   1122 C CD2 . PHE A 1 310 ? 135.982 124.557 115.630 1.00 51.31  ? 172 PHE R CD2 1 
ATOM   1123 C CE1 . PHE A 1 310 ? 137.611 125.849 113.826 1.00 55.05  ? 172 PHE R CE1 1 
ATOM   1124 C CE2 . PHE A 1 310 ? 137.204 125.049 116.038 1.00 52.42  ? 172 PHE R CE2 1 
ATOM   1125 C CZ  . PHE A 1 310 ? 138.020 125.697 115.134 1.00 57.58  ? 172 PHE R CZ  1 
ATOM   1126 N N   . ILE A 1 311 ? 131.092 123.937 113.518 1.00 50.42  ? 173 ILE R N   1 
ATOM   1127 C CA  . ILE A 1 311 ? 130.017 123.327 112.741 1.00 52.75  ? 173 ILE R CA  1 
ATOM   1128 C C   . ILE A 1 311 ? 128.988 124.368 112.312 1.00 56.95  ? 173 ILE R C   1 
ATOM   1129 O O   . ILE A 1 311 ? 128.553 124.387 111.154 1.00 61.39  ? 173 ILE R O   1 
ATOM   1130 C CB  . ILE A 1 311 ? 129.367 122.185 113.542 1.00 55.22  ? 173 ILE R CB  1 
ATOM   1131 C CG1 . ILE A 1 311 ? 130.367 121.049 113.759 1.00 59.58  ? 173 ILE R CG1 1 
ATOM   1132 C CG2 . ILE A 1 311 ? 128.132 121.667 112.826 1.00 54.83  ? 173 ILE R CG2 1 
ATOM   1133 C CD1 . ILE A 1 311 ? 129.782 119.852 114.472 1.00 59.85  ? 173 ILE R CD1 1 
ATOM   1134 N N   . PHE A 1 312 ? 128.590 125.256 113.223 1.00 56.69  ? 174 PHE R N   1 
ATOM   1135 C CA  . PHE A 1 312 ? 127.380 126.051 113.047 1.00 54.10  ? 174 PHE R CA  1 
ATOM   1136 C C   . PHE A 1 312 ? 127.624 127.489 112.612 1.00 57.64  ? 174 PHE R C   1 
ATOM   1137 O O   . PHE A 1 312 ? 126.809 128.032 111.862 1.00 62.66  ? 174 PHE R O   1 
ATOM   1138 C CB  . PHE A 1 312 ? 126.568 126.067 114.345 1.00 58.06  ? 174 PHE R CB  1 
ATOM   1139 C CG  . PHE A 1 312 ? 126.049 124.721 114.750 1.00 53.90  ? 174 PHE R CG  1 
ATOM   1140 C CD1 . PHE A 1 312 ? 125.442 123.893 113.823 1.00 51.17  ? 174 PHE R CD1 1 
ATOM   1141 C CD2 . PHE A 1 312 ? 126.164 124.286 116.057 1.00 49.41  ? 174 PHE R CD2 1 
ATOM   1142 C CE1 . PHE A 1 312 ? 124.962 122.655 114.191 1.00 51.26  ? 174 PHE R CE1 1 
ATOM   1143 C CE2 . PHE A 1 312 ? 125.686 123.050 116.430 1.00 55.14  ? 174 PHE R CE2 1 
ATOM   1144 C CZ  . PHE A 1 312 ? 125.084 122.233 115.496 1.00 59.04  ? 174 PHE R CZ  1 
ATOM   1145 N N   . ALA A 1 313 ? 128.699 128.128 113.071 1.00 58.51  ? 175 ALA R N   1 
ATOM   1146 C CA  . ALA A 1 313 ? 128.917 129.534 112.752 1.00 55.51  ? 175 ALA R CA  1 
ATOM   1147 C C   . ALA A 1 313 ? 129.040 129.726 111.247 1.00 58.62  ? 175 ALA R C   1 
ATOM   1148 O O   . ALA A 1 313 ? 129.865 129.080 110.594 1.00 65.12  ? 175 ALA R O   1 
ATOM   1149 C CB  . ALA A 1 313 ? 130.167 130.051 113.460 1.00 53.85  ? 175 ALA R CB  1 
ATOM   1150 N N   . ASN A 1 314 ? 128.216 130.616 110.700 1.00 62.82  ? 176 ASN R N   1 
ATOM   1151 C CA  . ASN A 1 314 ? 128.153 130.829 109.262 1.00 66.75  ? 176 ASN R CA  1 
ATOM   1152 C C   . ASN A 1 314 ? 127.768 132.278 108.997 1.00 71.11  ? 176 ASN R C   1 
ATOM   1153 O O   . ASN A 1 314 ? 127.473 133.043 109.919 1.00 73.94  ? 176 ASN R O   1 
ATOM   1154 C CB  . ASN A 1 314 ? 127.159 129.866 108.606 1.00 64.80  ? 176 ASN R CB  1 
ATOM   1155 C CG  . ASN A 1 314 ? 127.755 128.499 108.348 1.00 70.16  ? 176 ASN R CG  1 
ATOM   1156 O OD1 . ASN A 1 314 ? 128.909 128.379 107.938 1.00 68.99  ? 176 ASN R OD1 1 
ATOM   1157 N ND2 . ASN A 1 314 ? 126.969 127.456 108.591 1.00 71.93  ? 176 ASN R ND2 1 
ATOM   1158 N N   . VAL A 1 315 ? 127.770 132.650 107.720 1.00 75.45  ? 177 VAL R N   1 
ATOM   1159 C CA  . VAL A 1 315 ? 127.355 133.975 107.275 1.00 72.28  ? 177 VAL R CA  1 
ATOM   1160 C C   . VAL A 1 315 ? 126.150 133.802 106.364 1.00 70.03  ? 177 VAL R C   1 
ATOM   1161 O O   . VAL A 1 315 ? 126.255 133.180 105.300 1.00 75.07  ? 177 VAL R O   1 
ATOM   1162 C CB  . VAL A 1 315 ? 128.486 134.719 106.548 1.00 71.01  ? 177 VAL R CB  1 
ATOM   1163 C CG1 . VAL A 1 315 ? 127.936 135.927 105.811 1.00 72.26  ? 177 VAL R CG1 1 
ATOM   1164 C CG2 . VAL A 1 315 ? 129.561 135.140 107.531 1.00 74.76  ? 177 VAL R CG2 1 
ATOM   1165 N N   . SER A 1 316 ? 125.013 134.349 106.777 1.00 80.93  ? 178 SER R N   1 
ATOM   1166 C CA  . SER A 1 316 ? 123.817 134.281 105.957 1.00 85.04  ? 178 SER R CA  1 
ATOM   1167 C C   . SER A 1 316 ? 123.871 135.338 104.857 1.00 89.33  ? 178 SER R C   1 
ATOM   1168 O O   . SER A 1 316 ? 124.772 136.178 104.804 1.00 91.02  ? 178 SER R O   1 
ATOM   1169 C CB  . SER A 1 316 ? 122.566 134.464 106.813 1.00 84.15  ? 178 SER R CB  1 
ATOM   1170 O OG  . SER A 1 316 ? 121.424 134.677 106.003 1.00 91.71  ? 178 SER R OG  1 
ATOM   1171 N N   . GLU A 1 317 ? 122.885 135.288 103.968 1.00 105.74 ? 179 GLU R N   1 
ATOM   1172 C CA  . GLU A 1 317 ? 122.776 136.223 102.853 1.00 101.78 ? 179 GLU R CA  1 
ATOM   1173 C C   . GLU A 1 317 ? 121.353 136.756 102.763 1.00 104.57 ? 179 GLU R C   1 
ATOM   1174 O O   . GLU A 1 317 ? 120.721 136.760 101.706 1.00 109.13 ? 179 GLU R O   1 
ATOM   1175 C CB  . GLU A 1 317 ? 123.210 135.563 101.546 1.00 103.16 ? 179 GLU R CB  1 
ATOM   1176 C CG  . GLU A 1 317 ? 123.747 136.536 100.500 1.00 106.48 ? 179 GLU R CG  1 
ATOM   1177 C CD  . GLU A 1 317 ? 122.699 136.961 99.489  1.00 110.38 ? 179 GLU R CD  1 
ATOM   1178 O OE1 . GLU A 1 317 ? 121.811 136.144 99.169  1.00 111.41 ? 179 GLU R OE1 1 
ATOM   1179 O OE2 . GLU A 1 317 ? 122.765 138.115 99.014  1.00 108.98 ? 179 GLU R OE2 1 
ATOM   1180 N N   . ALA A 1 318 ? 120.827 137.205 103.899 1.00 110.47 ? 180 ALA R N   1 
ATOM   1181 C CA  . ALA A 1 318 ? 119.485 137.762 103.948 1.00 112.73 ? 180 ALA R CA  1 
ATOM   1182 C C   . ALA A 1 318 ? 119.437 139.087 103.187 1.00 115.22 ? 180 ALA R C   1 
ATOM   1183 O O   . ALA A 1 318 ? 120.432 139.555 102.625 1.00 114.25 ? 180 ALA R O   1 
ATOM   1184 C CB  . ALA A 1 318 ? 119.039 137.944 105.396 1.00 111.26 ? 180 ALA R CB  1 
ATOM   1185 N N   . ASP A 1 319 ? 118.253 139.695 103.164 1.00 123.37 ? 181 ASP R N   1 
ATOM   1186 C CA  . ASP A 1 319 ? 118.076 140.958 102.462 1.00 122.72 ? 181 ASP R CA  1 
ATOM   1187 C C   . ASP A 1 319 ? 118.975 142.034 103.058 1.00 121.95 ? 181 ASP R C   1 
ATOM   1188 O O   . ASP A 1 319 ? 119.185 142.088 104.273 1.00 118.88 ? 181 ASP R O   1 
ATOM   1189 C CB  . ASP A 1 319 ? 116.613 141.398 102.524 1.00 123.20 ? 181 ASP R CB  1 
ATOM   1190 C CG  . ASP A 1 319 ? 116.026 141.275 103.916 1.00 123.36 ? 181 ASP R CG  1 
ATOM   1191 O OD1 . ASP A 1 319 ? 116.693 140.691 104.795 1.00 123.59 ? 181 ASP R OD1 1 
ATOM   1192 O OD2 . ASP A 1 319 ? 114.896 141.761 104.131 1.00 122.11 ? 181 ASP R OD2 1 
ATOM   1193 N N   . ASP A 1 320 ? 119.519 142.882 102.183 1.00 115.03 ? 182 ASP R N   1 
ATOM   1194 C CA  . ASP A 1 320 ? 120.403 143.974 102.577 1.00 115.73 ? 182 ASP R CA  1 
ATOM   1195 C C   . ASP A 1 320 ? 121.643 143.459 103.300 1.00 115.69 ? 182 ASP R C   1 
ATOM   1196 O O   . ASP A 1 320 ? 122.632 143.084 102.661 1.00 112.30 ? 182 ASP R O   1 
ATOM   1197 C CB  . ASP A 1 320 ? 119.657 144.986 103.452 1.00 114.79 ? 182 ASP R CB  1 
ATOM   1198 C CG  . ASP A 1 320 ? 120.333 146.342 103.480 1.00 116.29 ? 182 ASP R CG  1 
ATOM   1199 O OD1 . ASP A 1 320 ? 120.270 147.061 102.460 1.00 115.28 ? 182 ASP R OD1 1 
ATOM   1200 O OD2 . ASP A 1 320 ? 120.926 146.691 104.522 1.00 118.47 ? 182 ASP R OD2 1 
ATOM   1201 N N   . ARG A 1 321 ? 121.597 143.442 104.628 1.00 92.84  ? 183 ARG R N   1 
ATOM   1202 C CA  . ARG A 1 321 ? 122.776 143.136 105.423 1.00 87.98  ? 183 ARG R CA  1 
ATOM   1203 C C   . ARG A 1 321 ? 123.166 141.664 105.308 1.00 91.47  ? 183 ARG R C   1 
ATOM   1204 O O   . ARG A 1 321 ? 122.383 140.810 104.883 1.00 93.15  ? 183 ARG R O   1 
ATOM   1205 C CB  . ARG A 1 321 ? 122.537 143.479 106.893 1.00 87.56  ? 183 ARG R CB  1 
ATOM   1206 C CG  . ARG A 1 321 ? 122.419 144.961 107.187 1.00 86.50  ? 183 ARG R CG  1 
ATOM   1207 C CD  . ARG A 1 321 ? 122.455 145.209 108.685 1.00 91.61  ? 183 ARG R CD  1 
ATOM   1208 N NE  . ARG A 1 321 ? 123.699 144.731 109.277 1.00 91.03  ? 183 ARG R NE  1 
ATOM   1209 C CZ  . ARG A 1 321 ? 123.780 143.746 110.161 1.00 87.33  ? 183 ARG R CZ  1 
ATOM   1210 N NH1 . ARG A 1 321 ? 122.702 143.110 110.587 1.00 86.70  ? 183 ARG R NH1 1 
ATOM   1211 N NH2 . ARG A 1 321 ? 124.972 143.391 110.630 1.00 85.30  ? 183 ARG R NH2 1 
ATOM   1212 N N   . TYR A 1 322 ? 124.407 141.383 105.695 1.00 91.49  ? 184 TYR R N   1 
ATOM   1213 C CA  . TYR A 1 322 ? 124.913 140.029 105.871 1.00 82.93  ? 184 TYR R CA  1 
ATOM   1214 C C   . TYR A 1 322 ? 125.072 139.774 107.363 1.00 81.64  ? 184 TYR R C   1 
ATOM   1215 O O   . TYR A 1 322 ? 125.696 140.574 108.067 1.00 87.78  ? 184 TYR R O   1 
ATOM   1216 C CB  . TYR A 1 322 ? 126.256 139.838 105.160 1.00 83.42  ? 184 TYR R CB  1 
ATOM   1217 C CG  . TYR A 1 322 ? 126.169 139.660 103.660 1.00 88.06  ? 184 TYR R CG  1 
ATOM   1218 C CD1 . TYR A 1 322 ? 125.187 140.297 102.916 1.00 90.88  ? 184 TYR R CD1 1 
ATOM   1219 C CD2 . TYR A 1 322 ? 127.081 138.857 102.988 1.00 88.74  ? 184 TYR R CD2 1 
ATOM   1220 C CE1 . TYR A 1 322 ? 125.112 140.136 101.545 1.00 91.40  ? 184 TYR R CE1 1 
ATOM   1221 C CE2 . TYR A 1 322 ? 127.014 138.690 101.619 1.00 90.08  ? 184 TYR R CE2 1 
ATOM   1222 C CZ  . TYR A 1 322 ? 126.028 139.332 100.903 1.00 91.53  ? 184 TYR R CZ  1 
ATOM   1223 O OH  . TYR A 1 322 ? 125.957 139.169 99.539  1.00 87.95  ? 184 TYR R OH  1 
ATOM   1224 N N   . ILE A 1 323 ? 124.515 138.667 107.842 1.00 80.50  ? 185 ILE R N   1 
ATOM   1225 C CA  . ILE A 1 323 ? 124.458 138.373 109.269 1.00 86.70  ? 185 ILE R CA  1 
ATOM   1226 C C   . ILE A 1 323 ? 125.490 137.304 109.597 1.00 82.44  ? 185 ILE R C   1 
ATOM   1227 O O   . ILE A 1 323 ? 125.568 136.273 108.919 1.00 87.91  ? 185 ILE R O   1 
ATOM   1228 C CB  . ILE A 1 323 ? 123.047 137.928 109.693 1.00 89.48  ? 185 ILE R CB  1 
ATOM   1229 C CG1 . ILE A 1 323 ? 122.031 139.054 109.473 1.00 87.84  ? 185 ILE R CG1 1 
ATOM   1230 C CG2 . ILE A 1 323 ? 123.038 137.495 111.148 1.00 87.37  ? 185 ILE R CG2 1 
ATOM   1231 C CD1 . ILE A 1 323 ? 121.382 139.059 108.102 1.00 87.24  ? 185 ILE R CD1 1 
ATOM   1232 N N   . CYS A 1 324 ? 126.286 137.552 110.634 1.00 64.63  ? 186 CYS R N   1 
ATOM   1233 C CA  . CYS A 1 324 ? 127.308 136.622 111.106 1.00 66.49  ? 186 CYS R CA  1 
ATOM   1234 C C   . CYS A 1 324 ? 126.916 136.159 112.506 1.00 79.35  ? 186 CYS R C   1 
ATOM   1235 O O   . CYS A 1 324 ? 127.304 136.773 113.503 1.00 94.75  ? 186 CYS R O   1 
ATOM   1236 C CB  . CYS A 1 324 ? 128.684 137.284 111.096 1.00 75.99  ? 186 CYS R CB  1 
ATOM   1237 S SG  . CYS A 1 324 ? 129.983 136.437 112.041 1.00 88.53  ? 186 CYS R SG  1 
ATOM   1238 N N   . ASP A 1 325 ? 126.143 135.079 112.574 1.00 67.95  ? 187 ASP R N   1 
ATOM   1239 C CA  . ASP A 1 325 ? 125.722 134.483 113.837 1.00 65.87  ? 187 ASP R CA  1 
ATOM   1240 C C   . ASP A 1 325 ? 125.721 132.968 113.673 1.00 71.81  ? 187 ASP R C   1 
ATOM   1241 O O   . ASP A 1 325 ? 126.170 132.436 112.653 1.00 75.67  ? 187 ASP R O   1 
ATOM   1242 C CB  . ASP A 1 325 ? 124.347 135.011 114.267 1.00 71.42  ? 187 ASP R CB  1 
ATOM   1243 C CG  . ASP A 1 325 ? 124.403 136.426 114.807 1.00 80.15  ? 187 ASP R CG  1 
ATOM   1244 O OD1 . ASP A 1 325 ? 125.426 136.795 115.419 1.00 79.75  ? 187 ASP R OD1 1 
ATOM   1245 O OD2 . ASP A 1 325 ? 123.420 137.173 114.621 1.00 82.15  ? 187 ASP R OD2 1 
ATOM   1246 N N   . ARG A 1 326 ? 125.211 132.270 114.683 1.00 70.53  ? 188 ARG R N   1 
ATOM   1247 C CA  . ARG A 1 326 ? 125.129 130.816 114.675 1.00 62.73  ? 188 ARG R CA  1 
ATOM   1248 C C   . ARG A 1 326 ? 123.735 130.392 114.237 1.00 59.34  ? 188 ARG R C   1 
ATOM   1249 O O   . ARG A 1 326 ? 122.736 130.870 114.785 1.00 66.86  ? 188 ARG R O   1 
ATOM   1250 C CB  . ARG A 1 326 ? 125.449 130.247 116.056 1.00 61.40  ? 188 ARG R CB  1 
ATOM   1251 C CG  . ARG A 1 326 ? 126.643 130.900 116.725 1.00 66.82  ? 188 ARG R CG  1 
ATOM   1252 C CD  . ARG A 1 326 ? 126.949 130.248 118.058 1.00 64.47  ? 188 ARG R CD  1 
ATOM   1253 N NE  . ARG A 1 326 ? 127.334 128.852 117.899 1.00 64.56  ? 188 ARG R NE  1 
ATOM   1254 C CZ  . ARG A 1 326 ? 127.765 128.077 118.885 1.00 68.96  ? 188 ARG R CZ  1 
ATOM   1255 N NH1 . ARG A 1 326 ? 127.885 128.533 120.120 1.00 69.97  ? 188 ARG R NH1 1 
ATOM   1256 N NH2 . ARG A 1 326 ? 128.086 126.815 118.623 1.00 69.68  ? 188 ARG R NH2 1 
ATOM   1257 N N   . PHE A 1 327 ? 123.670 129.496 113.257 1.00 58.06  ? 189 PHE R N   1 
ATOM   1258 C CA  . PHE A 1 327 ? 122.408 129.061 112.664 1.00 66.81  ? 189 PHE R CA  1 
ATOM   1259 C C   . PHE A 1 327 ? 122.208 127.578 112.958 1.00 70.02  ? 189 PHE R C   1 
ATOM   1260 O O   . PHE A 1 327 ? 122.582 126.717 112.158 1.00 66.97  ? 189 PHE R O   1 
ATOM   1261 C CB  . PHE A 1 327 ? 122.393 129.343 111.166 1.00 63.78  ? 189 PHE R CB  1 
ATOM   1262 C CG  . PHE A 1 327 ? 122.399 130.804 110.829 1.00 60.28  ? 189 PHE R CG  1 
ATOM   1263 C CD1 . PHE A 1 327 ? 121.222 131.531 110.827 1.00 64.87  ? 189 PHE R CD1 1 
ATOM   1264 C CD2 . PHE A 1 327 ? 123.582 131.453 110.523 1.00 64.77  ? 189 PHE R CD2 1 
ATOM   1265 C CE1 . PHE A 1 327 ? 121.224 132.876 110.522 1.00 68.71  ? 189 PHE R CE1 1 
ATOM   1266 C CE2 . PHE A 1 327 ? 123.590 132.798 110.217 1.00 70.77  ? 189 PHE R CE2 1 
ATOM   1267 C CZ  . PHE A 1 327 ? 122.410 133.510 110.217 1.00 70.08  ? 189 PHE R CZ  1 
ATOM   1268 N N   . TYR A 1 328 ? 121.612 127.283 114.109 1.00 61.97  ? 190 TYR R N   1 
ATOM   1269 C CA  . TYR A 1 328 ? 121.279 125.910 114.440 1.00 53.72  ? 190 TYR R CA  1 
ATOM   1270 C C   . TYR A 1 328 ? 120.088 125.444 113.605 1.00 64.45  ? 190 TYR R C   1 
ATOM   1271 O O   . TYR A 1 328 ? 119.171 126.222 113.331 1.00 68.49  ? 190 TYR R O   1 
ATOM   1272 C CB  . TYR A 1 328 ? 120.956 125.776 115.923 1.00 54.97  ? 190 TYR R CB  1 
ATOM   1273 C CG  . TYR A 1 328 ? 121.990 126.391 116.835 1.00 64.00  ? 190 TYR R CG  1 
ATOM   1274 C CD1 . TYR A 1 328 ? 123.069 125.651 117.289 1.00 64.65  ? 190 TYR R CD1 1 
ATOM   1275 C CD2 . TYR A 1 328 ? 121.880 127.708 117.254 1.00 63.03  ? 190 TYR R CD2 1 
ATOM   1276 C CE1 . TYR A 1 328 ? 124.014 126.207 118.124 1.00 59.51  ? 190 TYR R CE1 1 
ATOM   1277 C CE2 . TYR A 1 328 ? 122.818 128.271 118.091 1.00 57.21  ? 190 TYR R CE2 1 
ATOM   1278 C CZ  . TYR A 1 328 ? 123.882 127.516 118.523 1.00 55.19  ? 190 TYR R CZ  1 
ATOM   1279 O OH  . TYR A 1 328 ? 124.819 128.074 119.358 1.00 64.17  ? 190 TYR R OH  1 
ATOM   1280 N N   . PRO A 1 329 ? 120.085 124.179 113.179 1.00 79.17  ? 191 PRO R N   1 
ATOM   1281 C CA  . PRO A 1 329 ? 118.973 123.689 112.348 1.00 77.81  ? 191 PRO R CA  1 
ATOM   1282 C C   . PRO A 1 329 ? 117.607 123.810 113.001 1.00 77.87  ? 191 PRO R C   1 
ATOM   1283 O O   . PRO A 1 329 ? 116.621 124.067 112.300 1.00 78.06  ? 191 PRO R O   1 
ATOM   1284 C CB  . PRO A 1 329 ? 119.351 122.223 112.105 1.00 72.54  ? 191 PRO R CB  1 
ATOM   1285 C CG  . PRO A 1 329 ? 120.838 122.221 112.149 1.00 74.63  ? 191 PRO R CG  1 
ATOM   1286 C CD  . PRO A 1 329 ? 121.220 123.241 113.192 1.00 77.84  ? 191 PRO R CD  1 
ATOM   1287 N N   . ASN A 1 330 ? 117.512 123.637 114.317 1.00 81.96  ? 192 ASN R N   1 
ATOM   1288 C CA  . ASN A 1 330 ? 116.224 123.684 114.994 1.00 81.33  ? 192 ASN R CA  1 
ATOM   1289 C C   . ASN A 1 330 ? 116.386 124.373 116.343 1.00 84.13  ? 192 ASN R C   1 
ATOM   1290 O O   . ASN A 1 330 ? 117.488 124.476 116.886 1.00 88.55  ? 192 ASN R O   1 
ATOM   1291 C CB  . ASN A 1 330 ? 115.628 122.281 115.140 1.00 77.69  ? 192 ASN R CB  1 
ATOM   1292 C CG  . ASN A 1 330 ? 116.403 121.417 116.107 1.00 80.34  ? 192 ASN R CG  1 
ATOM   1293 O OD1 . ASN A 1 330 ? 116.298 121.575 117.320 1.00 81.02  ? 192 ASN R OD1 1 
ATOM   1294 N ND2 . ASN A 1 330 ? 117.191 120.492 115.572 1.00 81.32  ? 192 ASN R ND2 1 
ATOM   1295 N N   . ASP A 1 331 ? 115.258 124.845 116.882 1.00 81.82  ? 193 ASP R N   1 
ATOM   1296 C CA  . ASP A 1 331 ? 115.292 125.683 118.078 1.00 84.28  ? 193 ASP R CA  1 
ATOM   1297 C C   . ASP A 1 331 ? 115.659 124.881 119.321 1.00 81.05  ? 193 ASP R C   1 
ATOM   1298 O O   . ASP A 1 331 ? 116.140 125.444 120.315 1.00 78.92  ? 193 ASP R O   1 
ATOM   1299 C CB  . ASP A 1 331 ? 113.942 126.375 118.267 1.00 84.83  ? 193 ASP R CB  1 
ATOM   1300 C CG  . ASP A 1 331 ? 113.697 127.464 117.241 1.00 83.64  ? 193 ASP R CG  1 
ATOM   1301 O OD1 . ASP A 1 331 ? 114.680 128.085 116.785 1.00 82.33  ? 193 ASP R OD1 1 
ATOM   1302 O OD2 . ASP A 1 331 ? 112.522 127.697 116.890 1.00 84.76  ? 193 ASP R OD2 1 
ATOM   1303 N N   . LEU A 1 332 ? 115.426 123.568 119.295 1.00 72.99  ? 194 LEU R N   1 
ATOM   1304 C CA  . LEU A 1 332 ? 115.762 122.743 120.450 1.00 71.74  ? 194 LEU R CA  1 
ATOM   1305 C C   . LEU A 1 332 ? 117.257 122.800 120.734 1.00 73.54  ? 194 LEU R C   1 
ATOM   1306 O O   . LEU A 1 332 ? 117.679 122.887 121.892 1.00 74.50  ? 194 LEU R O   1 
ATOM   1307 C CB  . LEU A 1 332 ? 115.299 121.302 120.229 1.00 78.06  ? 194 LEU R CB  1 
ATOM   1308 C CG  . LEU A 1 332 ? 113.914 120.916 120.759 1.00 79.34  ? 194 LEU R CG  1 
ATOM   1309 C CD1 . LEU A 1 332 ? 113.879 121.008 122.275 1.00 77.51  ? 194 LEU R CD1 1 
ATOM   1310 C CD2 . LEU A 1 332 ? 112.816 121.774 120.144 1.00 77.24  ? 194 LEU R CD2 1 
ATOM   1311 N N   . TRP A 1 333 ? 118.079 122.776 119.684 1.00 80.46  ? 195 TRP R N   1 
ATOM   1312 C CA  . TRP A 1 333 ? 119.516 122.911 119.893 1.00 80.70  ? 195 TRP R CA  1 
ATOM   1313 C C   . TRP A 1 333 ? 119.868 124.314 120.370 1.00 74.51  ? 195 TRP R C   1 
ATOM   1314 O O   . TRP A 1 333 ? 120.817 124.498 121.138 1.00 80.10  ? 195 TRP R O   1 
ATOM   1315 C CB  . TRP A 1 333 ? 120.281 122.550 118.617 1.00 75.51  ? 195 TRP R CB  1 
ATOM   1316 C CG  . TRP A 1 333 ? 120.122 121.110 118.251 1.00 79.91  ? 195 TRP R CG  1 
ATOM   1317 C CD1 . TRP A 1 333 ? 119.609 120.121 119.039 1.00 82.55  ? 195 TRP R CD1 1 
ATOM   1318 C CD2 . TRP A 1 333 ? 120.493 120.486 117.019 1.00 75.90  ? 195 TRP R CD2 1 
ATOM   1319 N NE1 . TRP A 1 333 ? 119.624 118.925 118.369 1.00 78.52  ? 195 TRP R NE1 1 
ATOM   1320 C CE2 . TRP A 1 333 ? 120.164 119.121 117.126 1.00 78.46  ? 195 TRP R CE2 1 
ATOM   1321 C CE3 . TRP A 1 333 ? 121.066 120.949 115.833 1.00 79.52  ? 195 TRP R CE3 1 
ATOM   1322 C CZ2 . TRP A 1 333 ? 120.390 118.215 116.094 1.00 80.38  ? 195 TRP R CZ2 1 
ATOM   1323 C CZ3 . TRP A 1 333 ? 121.290 120.047 114.809 1.00 84.38  ? 195 TRP R CZ3 1 
ATOM   1324 C CH2 . TRP A 1 333 ? 120.952 118.697 114.946 1.00 83.47  ? 195 TRP R CH2 1 
ATOM   1325 N N   . VAL A 1 334 ? 119.091 125.315 119.954 1.00 58.19  ? 196 VAL R N   1 
ATOM   1326 C CA  . VAL A 1 334 ? 119.310 126.672 120.451 1.00 61.65  ? 196 VAL R CA  1 
ATOM   1327 C C   . VAL A 1 334 ? 119.152 126.706 121.966 1.00 69.28  ? 196 VAL R C   1 
ATOM   1328 O O   . VAL A 1 334 ? 120.015 127.219 122.693 1.00 69.04  ? 196 VAL R O   1 
ATOM   1329 C CB  . VAL A 1 334 ? 118.349 127.662 119.770 1.00 62.02  ? 196 VAL R CB  1 
ATOM   1330 C CG1 . VAL A 1 334 ? 118.578 129.068 120.297 1.00 63.75  ? 196 VAL R CG1 1 
ATOM   1331 C CG2 . VAL A 1 334 ? 118.513 127.615 118.263 1.00 67.76  ? 196 VAL R CG2 1 
ATOM   1332 N N   . VAL A 1 335 ? 118.048 126.141 122.464 1.00 77.82  ? 197 VAL R N   1 
ATOM   1333 C CA  . VAL A 1 335 ? 117.793 126.172 123.904 1.00 68.56  ? 197 VAL R CA  1 
ATOM   1334 C C   . VAL A 1 335 ? 118.786 125.284 124.645 1.00 57.88  ? 197 VAL R C   1 
ATOM   1335 O O   . VAL A 1 335 ? 119.201 125.598 125.765 1.00 53.71  ? 197 VAL R O   1 
ATOM   1336 C CB  . VAL A 1 335 ? 116.330 125.789 124.210 1.00 69.01  ? 197 VAL R CB  1 
ATOM   1337 C CG1 . VAL A 1 335 ? 116.096 124.298 124.071 1.00 68.55  ? 197 VAL R CG1 1 
ATOM   1338 C CG2 . VAL A 1 335 ? 115.943 126.257 125.603 1.00 65.09  ? 197 VAL R CG2 1 
ATOM   1339 N N   . VAL A 1 336 ? 119.202 124.176 124.025 1.00 68.52  ? 198 VAL R N   1 
ATOM   1340 C CA  . VAL A 1 336 ? 120.196 123.307 124.650 1.00 72.47  ? 198 VAL R CA  1 
ATOM   1341 C C   . VAL A 1 336 ? 121.524 124.036 124.814 1.00 71.98  ? 198 VAL R C   1 
ATOM   1342 O O   . VAL A 1 336 ? 122.160 123.966 125.875 1.00 77.29  ? 198 VAL R O   1 
ATOM   1343 C CB  . VAL A 1 336 ? 120.357 122.011 123.834 1.00 71.19  ? 198 VAL R CB  1 
ATOM   1344 C CG1 . VAL A 1 336 ? 121.636 121.290 124.219 1.00 70.68  ? 198 VAL R CG1 1 
ATOM   1345 C CG2 . VAL A 1 336 ? 119.155 121.106 124.042 1.00 72.06  ? 198 VAL R CG2 1 
ATOM   1346 N N   . PHE A 1 337 ? 121.961 124.754 123.777 1.00 63.67  ? 199 PHE R N   1 
ATOM   1347 C CA  . PHE A 1 337 ? 123.235 125.459 123.863 1.00 61.99  ? 199 PHE R CA  1 
ATOM   1348 C C   . PHE A 1 337 ? 123.157 126.616 124.851 1.00 66.71  ? 199 PHE R C   1 
ATOM   1349 O O   . PHE A 1 337 ? 124.102 126.847 125.619 1.00 73.71  ? 199 PHE R O   1 
ATOM   1350 C CB  . PHE A 1 337 ? 123.656 125.952 122.478 1.00 60.83  ? 199 PHE R CB  1 
ATOM   1351 C CG  . PHE A 1 337 ? 124.370 124.909 121.663 1.00 63.79  ? 199 PHE R CG  1 
ATOM   1352 C CD1 . PHE A 1 337 ? 125.723 124.710 121.809 1.00 64.10  ? 199 PHE R CD1 1 
ATOM   1353 C CD2 . PHE A 1 337 ? 123.683 124.128 120.758 1.00 69.17  ? 199 PHE R CD2 1 
ATOM   1354 C CE1 . PHE A 1 337 ? 126.380 123.745 121.074 1.00 62.81  ? 199 PHE R CE1 1 
ATOM   1355 C CE2 . PHE A 1 337 ? 124.331 123.168 120.013 1.00 73.60  ? 199 PHE R CE2 1 
ATOM   1356 C CZ  . PHE A 1 337 ? 125.686 122.975 120.171 1.00 67.84  ? 199 PHE R CZ  1 
ATOM   1357 N N   . GLN A 1 338 ? 122.031 127.335 124.869 1.00 64.34  ? 200 GLN R N   1 
ATOM   1358 C CA  . GLN A 1 338 ? 121.862 128.389 125.863 1.00 60.97  ? 200 GLN R CA  1 
ATOM   1359 C C   . GLN A 1 338 ? 121.891 127.831 127.280 1.00 63.72  ? 200 GLN R C   1 
ATOM   1360 O O   . GLN A 1 338 ? 122.557 128.400 128.156 1.00 64.11  ? 200 GLN R O   1 
ATOM   1361 C CB  . GLN A 1 338 ? 120.556 129.148 125.620 1.00 66.63  ? 200 GLN R CB  1 
ATOM   1362 C CG  . GLN A 1 338 ? 120.587 130.097 124.432 1.00 70.57  ? 200 GLN R CG  1 
ATOM   1363 C CD  . GLN A 1 338 ? 119.290 130.866 124.265 1.00 69.65  ? 200 GLN R CD  1 
ATOM   1364 O OE1 . GLN A 1 338 ? 118.334 130.662 125.011 1.00 73.89  ? 200 GLN R OE1 1 
ATOM   1365 N NE2 . GLN A 1 338 ? 119.253 131.757 123.282 1.00 63.28  ? 200 GLN R NE2 1 
ATOM   1366 N N   . PHE A 1 339 ? 121.199 126.713 127.517 1.00 74.04  ? 201 PHE R N   1 
ATOM   1367 C CA  . PHE A 1 339 ? 121.197 126.111 128.844 1.00 70.16  ? 201 PHE R CA  1 
ATOM   1368 C C   . PHE A 1 339 ? 122.575 125.616 129.248 1.00 66.03  ? 201 PHE R C   1 
ATOM   1369 O O   . PHE A 1 339 ? 122.959 125.767 130.408 1.00 73.86  ? 201 PHE R O   1 
ATOM   1370 C CB  . PHE A 1 339 ? 120.170 124.982 128.928 1.00 70.33  ? 201 PHE R CB  1 
ATOM   1371 C CG  . PHE A 1 339 ? 118.765 125.466 129.122 1.00 77.22  ? 201 PHE R CG  1 
ATOM   1372 C CD1 . PHE A 1 339 ? 118.527 126.770 129.513 1.00 74.18  ? 201 PHE R CD1 1 
ATOM   1373 C CD2 . PHE A 1 339 ? 117.684 124.621 128.931 1.00 79.35  ? 201 PHE R CD2 1 
ATOM   1374 C CE1 . PHE A 1 339 ? 117.242 127.228 129.704 1.00 69.00  ? 201 PHE R CE1 1 
ATOM   1375 C CE2 . PHE A 1 339 ? 116.392 125.078 129.120 1.00 76.43  ? 201 PHE R CE2 1 
ATOM   1376 C CZ  . PHE A 1 339 ? 116.173 126.384 129.506 1.00 69.99  ? 201 PHE R CZ  1 
ATOM   1377 N N   . GLN A 1 340 ? 123.340 125.012 128.334 1.00 65.31  ? 202 GLN R N   1 
ATOM   1378 C CA  . GLN A 1 340 ? 124.641 124.517 128.779 1.00 67.86  ? 202 GLN R CA  1 
ATOM   1379 C C   . GLN A 1 340 ? 125.612 125.668 129.014 1.00 67.31  ? 202 GLN R C   1 
ATOM   1380 O O   . GLN A 1 340 ? 126.453 125.596 129.917 1.00 73.52  ? 202 GLN R O   1 
ATOM   1381 C CB  . GLN A 1 340 ? 125.259 123.513 127.806 1.00 66.24  ? 202 GLN R CB  1 
ATOM   1382 C CG  . GLN A 1 340 ? 125.645 124.034 126.439 1.00 67.04  ? 202 GLN R CG  1 
ATOM   1383 C CD  . GLN A 1 340 ? 126.197 122.925 125.570 1.00 75.46  ? 202 GLN R CD  1 
ATOM   1384 O OE1 . GLN A 1 340 ? 126.330 121.786 126.015 1.00 75.24  ? 202 GLN R OE1 1 
ATOM   1385 N NE2 . GLN A 1 340 ? 126.584 123.266 124.347 1.00 78.98  ? 202 GLN R NE2 1 
ATOM   1386 N N   . HIS A 1 341 ? 125.522 126.731 128.210 1.00 57.16  ? 203 HIS R N   1 
ATOM   1387 C CA  . HIS A 1 341 ? 126.345 127.908 128.463 1.00 54.68  ? 203 HIS R CA  1 
ATOM   1388 C C   . HIS A 1 341 ? 126.032 128.496 129.833 1.00 56.49  ? 203 HIS R C   1 
ATOM   1389 O O   . HIS A 1 341 ? 126.938 128.721 130.646 1.00 63.95  ? 203 HIS R O   1 
ATOM   1390 C CB  . HIS A 1 341 ? 126.126 128.945 127.361 1.00 60.22  ? 203 HIS R CB  1 
ATOM   1391 C CG  . HIS A 1 341 ? 126.691 130.294 127.676 1.00 64.88  ? 203 HIS R CG  1 
ATOM   1392 N ND1 . HIS A 1 341 ? 126.069 131.466 127.302 1.00 67.71  ? 203 HIS R ND1 1 
ATOM   1393 C CD2 . HIS A 1 341 ? 127.830 130.659 128.309 1.00 65.77  ? 203 HIS R CD2 1 
ATOM   1394 C CE1 . HIS A 1 341 ? 126.794 132.494 127.705 1.00 62.18  ? 203 HIS R CE1 1 
ATOM   1395 N NE2 . HIS A 1 341 ? 127.868 132.032 128.319 1.00 70.02  ? 203 HIS R NE2 1 
ATOM   1396 N N   . ILE A 1 342 ? 124.744 128.714 130.122 1.00 48.47  ? 204 ILE R N   1 
ATOM   1397 C CA  . ILE A 1 342 ? 124.364 129.220 131.440 1.00 46.23  ? 204 ILE R CA  1 
ATOM   1398 C C   . ILE A 1 342 ? 124.860 128.278 132.525 1.00 54.93  ? 204 ILE R C   1 
ATOM   1399 O O   . ILE A 1 342 ? 125.558 128.693 133.458 1.00 62.82  ? 204 ILE R O   1 
ATOM   1400 C CB  . ILE A 1 342 ? 122.840 129.415 131.532 1.00 55.15  ? 204 ILE R CB  1 
ATOM   1401 C CG1 . ILE A 1 342 ? 122.375 130.546 130.617 1.00 64.81  ? 204 ILE R CG1 1 
ATOM   1402 C CG2 . ILE A 1 342 ? 122.427 129.692 132.968 1.00 50.94  ? 204 ILE R CG2 1 
ATOM   1403 C CD1 . ILE A 1 342 ? 120.865 130.663 130.524 1.00 60.78  ? 204 ILE R CD1 1 
ATOM   1404 N N   . MET A 1 343 ? 124.559 126.985 132.382 1.00 57.55  ? 205 MET R N   1 
ATOM   1405 C CA  . MET A 1 343 ? 124.914 125.997 133.391 1.00 52.60  ? 205 MET R CA  1 
ATOM   1406 C C   . MET A 1 343 ? 126.401 126.040 133.688 1.00 55.26  ? 205 MET R C   1 
ATOM   1407 O O   . MET A 1 343 ? 126.810 126.440 134.781 1.00 67.91  ? 205 MET R O   1 
ATOM   1408 C CB  . MET A 1 343 ? 124.497 124.601 132.925 1.00 54.67  ? 205 MET R CB  1 
ATOM   1409 C CG  . MET A 1 343 ? 124.699 123.512 133.961 1.00 58.04  ? 205 MET R CG  1 
ATOM   1410 S SD  . MET A 1 343 ? 123.644 123.724 135.403 1.00 74.95  ? 205 MET R SD  1 
ATOM   1411 C CE  . MET A 1 343 ? 122.033 123.406 134.689 1.00 57.05  ? 205 MET R CE  1 
ATOM   1412 N N   . VAL A 1 344 ? 127.230 125.695 132.704 1.00 44.14  ? 206 VAL R N   1 
ATOM   1413 C CA  . VAL A 1 344 ? 128.668 125.651 132.928 1.00 51.29  ? 206 VAL R CA  1 
ATOM   1414 C C   . VAL A 1 344 ? 129.127 127.001 133.458 1.00 52.98  ? 206 VAL R C   1 
ATOM   1415 O O   . VAL A 1 344 ? 129.409 127.129 134.658 1.00 60.96  ? 206 VAL R O   1 
ATOM   1416 C CB  . VAL A 1 344 ? 129.425 125.274 131.643 1.00 51.07  ? 206 VAL R CB  1 
ATOM   1417 C CG1 . VAL A 1 344 ? 130.920 125.464 131.834 1.00 46.80  ? 206 VAL R CG1 1 
ATOM   1418 C CG2 . VAL A 1 344 ? 129.112 123.842 131.245 1.00 51.34  ? 206 VAL R CG2 1 
ATOM   1419 N N   . GLY A 1 345 ? 129.039 128.041 132.618 1.00 44.24  ? 207 GLY R N   1 
ATOM   1420 C CA  . GLY A 1 345 ? 129.720 129.285 132.881 1.00 44.36  ? 207 GLY R CA  1 
ATOM   1421 C C   . GLY A 1 345 ? 129.082 130.199 133.896 1.00 42.39  ? 207 GLY R C   1 
ATOM   1422 O O   . GLY A 1 345 ? 129.544 131.332 134.053 1.00 49.48  ? 207 GLY R O   1 
ATOM   1423 N N   . LEU A 1 346 ? 128.029 129.768 134.588 1.00 32.27  ? 208 LEU R N   1 
ATOM   1424 C CA  . LEU A 1 346 ? 127.545 130.565 135.703 1.00 40.97  ? 208 LEU R CA  1 
ATOM   1425 C C   . LEU A 1 346 ? 127.444 129.724 136.967 1.00 44.96  ? 208 LEU R C   1 
ATOM   1426 O O   . LEU A 1 346 ? 127.701 130.225 138.066 1.00 58.83  ? 208 LEU R O   1 
ATOM   1427 C CB  . LEU A 1 346 ? 126.192 131.193 135.370 1.00 48.28  ? 208 LEU R CB  1 
ATOM   1428 C CG  . LEU A 1 346 ? 125.594 132.091 136.456 1.00 50.00  ? 208 LEU R CG  1 
ATOM   1429 C CD1 . LEU A 1 346 ? 126.472 133.311 136.687 1.00 45.21  ? 208 LEU R CD1 1 
ATOM   1430 C CD2 . LEU A 1 346 ? 124.178 132.506 136.093 1.00 51.02  ? 208 LEU R CD2 1 
ATOM   1431 N N   . ILE A 1 347 ? 127.077 128.452 136.838 1.00 35.36  ? 209 ILE R N   1 
ATOM   1432 C CA  . ILE A 1 347 ? 126.810 127.633 138.008 1.00 38.82  ? 209 ILE R CA  1 
ATOM   1433 C C   . ILE A 1 347 ? 128.046 126.863 138.454 1.00 40.54  ? 209 ILE R C   1 
ATOM   1434 O O   . ILE A 1 347 ? 128.316 126.778 139.654 1.00 57.73  ? 209 ILE R O   1 
ATOM   1435 C CB  . ILE A 1 347 ? 125.626 126.693 137.714 1.00 42.44  ? 209 ILE R CB  1 
ATOM   1436 C CG1 . ILE A 1 347 ? 124.346 127.510 137.530 1.00 43.43  ? 209 ILE R CG1 1 
ATOM   1437 C CG2 . ILE A 1 347 ? 125.456 125.678 138.824 1.00 40.53  ? 209 ILE R CG2 1 
ATOM   1438 C CD1 . ILE A 1 347 ? 123.089 126.678 137.461 1.00 48.02  ? 209 ILE R CD1 1 
ATOM   1439 N N   . LEU A 1 348 ? 128.837 126.281 137.535 1.00 37.01  ? 210 LEU R N   1 
ATOM   1440 C CA  . LEU A 1 348 ? 129.913 125.413 138.013 1.00 42.00  ? 210 LEU R CA  1 
ATOM   1441 C C   . LEU A 1 348 ? 131.024 126.212 138.686 1.00 43.36  ? 210 LEU R C   1 
ATOM   1442 O O   . LEU A 1 348 ? 131.338 125.927 139.859 1.00 50.02  ? 210 LEU R O   1 
ATOM   1443 C CB  . LEU A 1 348 ? 130.421 124.527 136.872 1.00 44.71  ? 210 LEU R CB  1 
ATOM   1444 C CG  . LEU A 1 348 ? 129.401 123.542 136.296 1.00 43.37  ? 210 LEU R CG  1 
ATOM   1445 C CD1 . LEU A 1 348 ? 130.099 122.443 135.511 1.00 44.91  ? 210 LEU R CD1 1 
ATOM   1446 C CD2 . LEU A 1 348 ? 128.533 122.950 137.395 1.00 38.78  ? 210 LEU R CD2 1 
ATOM   1447 N N   . PRO A 1 349 ? 131.636 127.219 138.050 1.00 35.43  ? 211 PRO R N   1 
ATOM   1448 C CA  . PRO A 1 349 ? 132.516 128.107 138.817 1.00 43.58  ? 211 PRO R CA  1 
ATOM   1449 C C   . PRO A 1 349 ? 131.784 128.818 139.930 1.00 48.32  ? 211 PRO R C   1 
ATOM   1450 O O   . PRO A 1 349 ? 132.388 129.101 140.967 1.00 54.10  ? 211 PRO R O   1 
ATOM   1451 C CB  . PRO A 1 349 ? 133.037 129.091 137.761 1.00 49.83  ? 211 PRO R CB  1 
ATOM   1452 C CG  . PRO A 1 349 ? 132.842 128.402 136.475 1.00 55.04  ? 211 PRO R CG  1 
ATOM   1453 C CD  . PRO A 1 349 ? 131.583 127.634 136.640 1.00 44.20  ? 211 PRO R CD  1 
ATOM   1454 N N   . GLY A 1 350 ? 130.494 129.104 139.752 1.00 40.37  ? 212 GLY R N   1 
ATOM   1455 C CA  . GLY A 1 350 ? 129.736 129.719 140.828 1.00 39.94  ? 212 GLY R CA  1 
ATOM   1456 C C   . GLY A 1 350 ? 129.724 128.868 142.082 1.00 38.58  ? 212 GLY R C   1 
ATOM   1457 O O   . GLY A 1 350 ? 130.006 129.355 143.177 1.00 43.71  ? 212 GLY R O   1 
ATOM   1458 N N   . ILE A 1 351 ? 129.440 127.573 141.932 1.00 32.34  ? 213 ILE R N   1 
ATOM   1459 C CA  . ILE A 1 351 ? 129.392 126.687 143.092 1.00 28.06  ? 213 ILE R CA  1 
ATOM   1460 C C   . ILE A 1 351 ? 130.786 126.469 143.667 1.00 41.54  ? 213 ILE R C   1 
ATOM   1461 O O   . ILE A 1 351 ? 130.969 126.455 144.893 1.00 51.38  ? 213 ILE R O   1 
ATOM   1462 C CB  . ILE A 1 351 ? 128.714 125.355 142.726 1.00 31.34  ? 213 ILE R CB  1 
ATOM   1463 C CG1 . ILE A 1 351 ? 127.209 125.556 142.549 1.00 39.04  ? 213 ILE R CG1 1 
ATOM   1464 C CG2 . ILE A 1 351 ? 128.985 124.302 143.783 1.00 38.31  ? 213 ILE R CG2 1 
ATOM   1465 C CD1 . ILE A 1 351 ? 126.497 124.337 142.016 1.00 45.11  ? 213 ILE R CD1 1 
ATOM   1466 N N   . VAL A 1 352 ? 131.792 126.293 142.804 1.00 41.31  ? 214 VAL R N   1 
ATOM   1467 C CA  . VAL A 1 352 ? 133.147 126.080 143.313 1.00 40.37  ? 214 VAL R CA  1 
ATOM   1468 C C   . VAL A 1 352 ? 133.622 127.295 144.104 1.00 40.40  ? 214 VAL R C   1 
ATOM   1469 O O   . VAL A 1 352 ? 134.188 127.164 145.198 1.00 51.43  ? 214 VAL R O   1 
ATOM   1470 C CB  . VAL A 1 352 ? 134.108 125.739 142.161 1.00 41.63  ? 214 VAL R CB  1 
ATOM   1471 C CG1 . VAL A 1 352 ? 135.537 125.700 142.665 1.00 34.32  ? 214 VAL R CG1 1 
ATOM   1472 C CG2 . VAL A 1 352 ? 133.730 124.410 141.538 1.00 42.47  ? 214 VAL R CG2 1 
ATOM   1473 N N   . ILE A 1 353 ? 133.383 128.497 143.572 1.00 33.38  ? 215 ILE R N   1 
ATOM   1474 C CA  . ILE A 1 353 ? 133.779 129.721 144.257 1.00 35.25  ? 215 ILE R CA  1 
ATOM   1475 C C   . ILE A 1 353 ? 132.981 129.900 145.542 1.00 48.62  ? 215 ILE R C   1 
ATOM   1476 O O   . ILE A 1 353 ? 133.531 130.307 146.570 1.00 55.42  ? 215 ILE R O   1 
ATOM   1477 C CB  . ILE A 1 353 ? 133.623 130.927 143.314 1.00 39.48  ? 215 ILE R CB  1 
ATOM   1478 C CG1 . ILE A 1 353 ? 134.685 130.879 142.216 1.00 44.56  ? 215 ILE R CG1 1 
ATOM   1479 C CG2 . ILE A 1 353 ? 133.719 132.230 144.085 1.00 43.13  ? 215 ILE R CG2 1 
ATOM   1480 C CD1 . ILE A 1 353 ? 134.335 131.694 140.994 1.00 41.83  ? 215 ILE R CD1 1 
ATOM   1481 N N   . LEU A 1 354 ? 131.677 129.604 145.509 1.00 45.41  ? 216 LEU R N   1 
ATOM   1482 C CA  . LEU A 1 354 ? 130.875 129.666 146.726 1.00 34.39  ? 216 LEU R CA  1 
ATOM   1483 C C   . LEU A 1 354 ? 131.479 128.806 147.823 1.00 44.66  ? 216 LEU R C   1 
ATOM   1484 O O   . LEU A 1 354 ? 131.705 129.279 148.940 1.00 56.69  ? 216 LEU R O   1 
ATOM   1485 C CB  . LEU A 1 354 ? 129.440 129.223 146.444 1.00 38.04  ? 216 LEU R CB  1 
ATOM   1486 C CG  . LEU A 1 354 ? 128.456 130.237 145.870 1.00 47.36  ? 216 LEU R CG  1 
ATOM   1487 C CD1 . LEU A 1 354 ? 127.174 129.542 145.459 1.00 53.17  ? 216 LEU R CD1 1 
ATOM   1488 C CD2 . LEU A 1 354 ? 128.163 131.282 146.918 1.00 39.71  ? 216 LEU R CD2 1 
ATOM   1489 N N   . SER A 1 355 ? 131.763 127.540 147.519 1.00 34.18  ? 217 SER R N   1 
ATOM   1490 C CA  . SER A 1 355 ? 132.296 126.644 148.541 1.00 36.58  ? 217 SER R CA  1 
ATOM   1491 C C   . SER A 1 355 ? 133.651 127.128 149.045 1.00 39.71  ? 217 SER R C   1 
ATOM   1492 O O   . SER A 1 355 ? 133.868 127.259 150.261 1.00 50.26  ? 217 SER R O   1 
ATOM   1493 C CB  . SER A 1 355 ? 132.398 125.226 147.987 1.00 39.76  ? 217 SER R CB  1 
ATOM   1494 O OG  . SER A 1 355 ? 131.121 124.736 147.617 1.00 47.54  ? 217 SER R OG  1 
ATOM   1495 N N   . CYS A 1 356 ? 134.569 127.425 148.120 1.00 32.90  ? 218 CYS R N   1 
ATOM   1496 C CA  . CYS A 1 356 ? 135.919 127.811 148.517 1.00 32.63  ? 218 CYS R CA  1 
ATOM   1497 C C   . CYS A 1 356 ? 135.903 129.072 149.370 1.00 44.36  ? 218 CYS R C   1 
ATOM   1498 O O   . CYS A 1 356 ? 136.529 129.122 150.435 1.00 59.99  ? 218 CYS R O   1 
ATOM   1499 C CB  . CYS A 1 356 ? 136.792 128.011 147.279 1.00 39.18  ? 218 CYS R CB  1 
ATOM   1500 S SG  . CYS A 1 356 ? 137.437 126.484 146.572 1.00 68.45  ? 218 CYS R SG  1 
ATOM   1501 N N   . TYR A 1 357 ? 135.169 130.097 148.936 1.00 42.55  ? 219 TYR R N   1 
ATOM   1502 C CA  . TYR A 1 357 ? 135.203 131.357 149.660 1.00 38.06  ? 219 TYR R CA  1 
ATOM   1503 C C   . TYR A 1 357 ? 134.354 131.327 150.921 1.00 37.25  ? 219 TYR R C   1 
ATOM   1504 O O   . TYR A 1 357 ? 134.666 132.045 151.871 1.00 47.38  ? 219 TYR R O   1 
ATOM   1505 C CB  . TYR A 1 357 ? 134.785 132.503 148.744 1.00 38.77  ? 219 TYR R CB  1 
ATOM   1506 C CG  . TYR A 1 357 ? 135.971 133.061 148.004 1.00 42.27  ? 219 TYR R CG  1 
ATOM   1507 C CD1 . TYR A 1 357 ? 136.941 133.792 148.670 1.00 47.47  ? 219 TYR R CD1 1 
ATOM   1508 C CD2 . TYR A 1 357 ? 136.143 132.826 146.650 1.00 43.97  ? 219 TYR R CD2 1 
ATOM   1509 C CE1 . TYR A 1 357 ? 138.038 134.288 148.007 1.00 47.47  ? 219 TYR R CE1 1 
ATOM   1510 C CE2 . TYR A 1 357 ? 137.237 133.321 145.979 1.00 44.36  ? 219 TYR R CE2 1 
ATOM   1511 C CZ  . TYR A 1 357 ? 138.181 134.053 146.661 1.00 46.65  ? 219 TYR R CZ  1 
ATOM   1512 O OH  . TYR A 1 357 ? 139.275 134.550 145.995 1.00 53.47  ? 219 TYR R OH  1 
ATOM   1513 N N   . CYS A 1 358 ? 133.308 130.501 150.979 1.00 34.43  ? 220 CYS R N   1 
ATOM   1514 C CA  . CYS A 1 358 ? 132.601 130.322 152.239 1.00 35.07  ? 220 CYS R CA  1 
ATOM   1515 C C   . CYS A 1 358 ? 133.522 129.712 153.286 1.00 40.55  ? 220 CYS R C   1 
ATOM   1516 O O   . CYS A 1 358 ? 133.589 130.190 154.426 1.00 50.03  ? 220 CYS R O   1 
ATOM   1517 C CB  . CYS A 1 358 ? 131.363 129.451 152.027 1.00 41.64  ? 220 CYS R CB  1 
ATOM   1518 S SG  . CYS A 1 358 ? 130.467 129.045 153.538 1.00 71.57  ? 220 CYS R SG  1 
ATOM   1519 N N   . ILE A 1 359 ? 134.276 128.677 152.903 1.00 40.81  ? 221 ILE R N   1 
ATOM   1520 C CA  . ILE A 1 359 ? 135.220 128.081 153.846 1.00 42.53  ? 221 ILE R CA  1 
ATOM   1521 C C   . ILE A 1 359 ? 136.307 129.083 154.223 1.00 44.71  ? 221 ILE R C   1 
ATOM   1522 O O   . ILE A 1 359 ? 136.695 129.192 155.394 1.00 52.38  ? 221 ILE R O   1 
ATOM   1523 C CB  . ILE A 1 359 ? 135.816 126.786 153.268 1.00 42.00  ? 221 ILE R CB  1 
ATOM   1524 C CG1 . ILE A 1 359 ? 134.708 125.772 152.988 1.00 44.88  ? 221 ILE R CG1 1 
ATOM   1525 C CG2 . ILE A 1 359 ? 136.822 126.192 154.232 1.00 43.85  ? 221 ILE R CG2 1 
ATOM   1526 C CD1 . ILE A 1 359 ? 133.902 125.403 154.209 1.00 50.31  ? 221 ILE R CD1 1 
ATOM   1527 N N   . ILE A 1 360 ? 136.806 129.841 153.243 1.00 39.34  ? 222 ILE R N   1 
ATOM   1528 C CA  . ILE A 1 360 ? 137.875 130.802 153.508 1.00 37.31  ? 222 ILE R CA  1 
ATOM   1529 C C   . ILE A 1 360 ? 137.401 131.885 154.472 1.00 44.47  ? 222 ILE R C   1 
ATOM   1530 O O   . ILE A 1 360 ? 138.107 132.247 155.420 1.00 54.07  ? 222 ILE R O   1 
ATOM   1531 C CB  . ILE A 1 360 ? 138.389 131.404 152.188 1.00 48.28  ? 222 ILE R CB  1 
ATOM   1532 C CG1 . ILE A 1 360 ? 139.353 130.436 151.505 1.00 51.42  ? 222 ILE R CG1 1 
ATOM   1533 C CG2 . ILE A 1 360 ? 139.065 132.741 152.430 1.00 51.15  ? 222 ILE R CG2 1 
ATOM   1534 C CD1 . ILE A 1 360 ? 139.866 130.931 150.176 1.00 51.16  ? 222 ILE R CD1 1 
ATOM   1535 N N   . ILE A 1 361 ? 136.198 132.419 154.247 1.00 42.36  ? 223 ILE R N   1 
ATOM   1536 C CA  . ILE A 1 361 ? 135.677 133.473 155.110 1.00 33.80  ? 223 ILE R CA  1 
ATOM   1537 C C   . ILE A 1 361 ? 135.393 132.932 156.505 1.00 37.94  ? 223 ILE R C   1 
ATOM   1538 O O   . ILE A 1 361 ? 135.625 133.618 157.507 1.00 50.43  ? 223 ILE R O   1 
ATOM   1539 C CB  . ILE A 1 361 ? 134.429 134.113 154.478 1.00 44.18  ? 223 ILE R CB  1 
ATOM   1540 C CG1 . ILE A 1 361 ? 134.808 134.882 153.211 1.00 45.55  ? 223 ILE R CG1 1 
ATOM   1541 C CG2 . ILE A 1 361 ? 133.739 135.039 155.462 1.00 46.37  ? 223 ILE R CG2 1 
ATOM   1542 C CD1 . ILE A 1 361 ? 135.896 135.906 153.420 1.00 44.92  ? 223 ILE R CD1 1 
ATOM   1543 N N   . SER A 1 362 ? 134.895 131.695 156.601 1.00 37.33  ? 224 SER R N   1 
ATOM   1544 C CA  . SER A 1 362 ? 134.699 131.096 157.916 1.00 35.76  ? 224 SER R CA  1 
ATOM   1545 C C   . SER A 1 362 ? 136.025 130.928 158.645 1.00 45.44  ? 224 SER R C   1 
ATOM   1546 O O   . SER A 1 362 ? 136.084 131.036 159.875 1.00 52.86  ? 224 SER R O   1 
ATOM   1547 C CB  . SER A 1 362 ? 133.983 129.754 157.784 1.00 43.51  ? 224 SER R CB  1 
ATOM   1548 O OG  . SER A 1 362 ? 132.678 129.927 157.262 1.00 52.36  ? 224 SER R OG  1 
ATOM   1549 N N   . ARG A 1 363 ? 137.101 130.654 157.904 1.00 50.95  ? 225 ARG R N   1 
ATOM   1550 C CA  . ARG A 1 363 ? 138.419 130.567 158.527 1.00 42.87  ? 225 ARG R CA  1 
ATOM   1551 C C   . ARG A 1 363 ? 138.915 131.936 158.979 1.00 39.81  ? 225 ARG R C   1 
ATOM   1552 O O   . ARG A 1 363 ? 139.503 132.063 160.058 1.00 43.75  ? 225 ARG R O   1 
ATOM   1553 C CB  . ARG A 1 363 ? 139.419 129.938 157.559 1.00 47.83  ? 225 ARG R CB  1 
ATOM   1554 C CG  . ARG A 1 363 ? 139.411 128.422 157.549 1.00 51.83  ? 225 ARG R CG  1 
ATOM   1555 C CD  . ARG A 1 363 ? 139.475 127.857 158.957 1.00 50.22  ? 225 ARG R CD  1 
ATOM   1556 N NE  . ARG A 1 363 ? 139.523 126.399 158.963 1.00 54.37  ? 225 ARG R NE  1 
ATOM   1557 C CZ  . ARG A 1 363 ? 138.515 125.608 158.618 1.00 58.92  ? 225 ARG R CZ  1 
ATOM   1558 N NH1 . ARG A 1 363 ? 137.342 126.099 158.254 1.00 54.42  ? 225 ARG R NH1 1 
ATOM   1559 N NH2 . ARG A 1 363 ? 138.688 124.290 158.645 1.00 60.00  ? 225 ARG R NH2 1 
ATOM   1560 N N   . LEU A 1 364 ? 138.692 132.970 158.163 1.00 49.50  ? 226 LEU R N   1 
ATOM   1561 C CA  . LEU A 1 364 ? 139.237 134.292 158.463 1.00 49.54  ? 226 LEU R CA  1 
ATOM   1562 C C   . LEU A 1 364 ? 138.625 134.882 159.728 1.00 51.87  ? 226 LEU R C   1 
ATOM   1563 O O   . LEU A 1 364 ? 139.326 135.514 160.526 1.00 57.14  ? 226 LEU R O   1 
ATOM   1564 C CB  . LEU A 1 364 ? 139.018 135.230 157.277 1.00 49.80  ? 226 LEU R CB  1 
ATOM   1565 C CG  . LEU A 1 364 ? 139.821 134.941 156.008 1.00 48.50  ? 226 LEU R CG  1 
ATOM   1566 C CD1 . LEU A 1 364 ? 139.362 135.834 154.870 1.00 50.73  ? 226 LEU R CD1 1 
ATOM   1567 C CD2 . LEU A 1 364 ? 141.306 135.115 156.257 1.00 51.01  ? 226 LEU R CD2 1 
ATOM   1568 N N   . LYS A 1 365 ? 137.321 134.697 159.925 1.00 55.48  ? 227 LYS R N   1 
ATOM   1569 C CA  . LYS A 1 365 ? 136.643 135.258 161.086 1.00 52.13  ? 227 LYS R CA  1 
ATOM   1570 C C   . LYS A 1 365 ? 136.894 134.476 162.367 1.00 59.64  ? 227 LYS R C   1 
ATOM   1571 O O   . LYS A 1 365 ? 136.534 134.961 163.445 1.00 66.81  ? 227 LYS R O   1 
ATOM   1572 C CB  . LYS A 1 365 ? 135.135 135.331 160.834 1.00 47.16  ? 227 LYS R CB  1 
ATOM   1573 C CG  . LYS A 1 365 ? 134.740 136.187 159.648 1.00 57.23  ? 227 LYS R CG  1 
ATOM   1574 C CD  . LYS A 1 365 ? 133.261 136.526 159.693 1.00 61.70  ? 227 LYS R CD  1 
ATOM   1575 C CE  . LYS A 1 365 ? 132.890 137.530 158.615 1.00 59.95  ? 227 LYS R CE  1 
ATOM   1576 N NZ  . LYS A 1 365 ? 131.544 137.250 158.044 1.00 60.37  ? 227 LYS R NZ  1 
ATOM   1577 N N   . SER A 1 366 ? 137.493 133.292 162.286 1.00 54.20  ? 228 SER R N   1 
ATOM   1578 C CA  . SER A 1 366 ? 137.666 132.428 163.447 1.00 50.67  ? 228 SER R CA  1 
ATOM   1579 C C   . SER A 1 366 ? 139.114 132.243 163.866 1.00 52.84  ? 228 SER R C   1 
ATOM   1580 O O   . SER A 1 366 ? 139.415 132.309 165.059 1.00 58.32  ? 228 SER R O   1 
ATOM   1581 C CB  . SER A 1 366 ? 137.047 131.053 163.175 1.00 53.42  ? 228 SER R CB  1 
ATOM   1582 O OG  . SER A 1 366 ? 137.939 130.231 162.444 1.00 57.91  ? 228 SER R OG  1 
ATOM   1583 N N   . VAL A 1 367 ? 140.024 132.012 162.920 1.00 57.23  ? 229 VAL R N   1 
ATOM   1584 C CA  . VAL A 1 367 ? 141.405 131.714 163.275 1.00 58.28  ? 229 VAL R CA  1 
ATOM   1585 C C   . VAL A 1 367 ? 142.092 132.979 163.768 1.00 58.49  ? 229 VAL R C   1 
ATOM   1586 O O   . VAL A 1 367 ? 142.082 134.017 163.094 1.00 55.61  ? 229 VAL R O   1 
ATOM   1587 C CB  . VAL A 1 367 ? 142.152 131.105 162.080 1.00 59.99  ? 229 VAL R CB  1 
ATOM   1588 C CG1 . VAL A 1 367 ? 143.621 130.921 162.419 1.00 56.78  ? 229 VAL R CG1 1 
ATOM   1589 C CG2 . VAL A 1 367 ? 141.523 129.779 161.688 1.00 64.23  ? 229 VAL R CG2 1 
ATOM   1590 N N   . ARG A 1 368 ? 142.691 132.895 164.958 1.00 73.86  ? 230 ARG R N   1 
ATOM   1591 C CA  . ARG A 1 368 ? 143.402 134.040 165.516 1.00 75.22  ? 230 ARG R CA  1 
ATOM   1592 C C   . ARG A 1 368 ? 144.617 134.405 164.675 1.00 73.11  ? 230 ARG R C   1 
ATOM   1593 O O   . ARG A 1 368 ? 144.866 135.587 164.413 1.00 76.59  ? 230 ARG R O   1 
ATOM   1594 C CB  . ARG A 1 368 ? 143.820 133.742 166.955 1.00 69.07  ? 230 ARG R CB  1 
ATOM   1595 C CG  . ARG A 1 368 ? 144.495 134.902 167.661 1.00 66.50  ? 230 ARG R CG  1 
ATOM   1596 C CD  . ARG A 1 368 ? 145.119 134.455 168.969 1.00 69.03  ? 230 ARG R CD  1 
ATOM   1597 N NE  . ARG A 1 368 ? 146.439 133.870 168.769 1.00 72.42  ? 230 ARG R NE  1 
ATOM   1598 C CZ  . ARG A 1 368 ? 147.571 134.420 169.185 1.00 72.24  ? 230 ARG R CZ  1 
ATOM   1599 N NH1 . ARG A 1 368 ? 147.581 135.568 169.841 1.00 69.74  ? 230 ARG R NH1 1 
ATOM   1600 N NH2 . ARG A 1 368 ? 148.722 133.802 168.937 1.00 73.53  ? 230 ARG R NH2 1 
ATOM   1601 N N   . LEU A 1 369 ? 145.382 133.407 164.237 1.00 75.43  ? 231 LEU R N   1 
ATOM   1602 C CA  . LEU A 1 369 ? 146.621 133.661 163.507 1.00 76.54  ? 231 LEU R CA  1 
ATOM   1603 C C   . LEU A 1 369 ? 146.820 132.537 162.502 1.00 78.38  ? 231 LEU R C   1 
ATOM   1604 O O   . LEU A 1 369 ? 147.174 131.419 162.886 1.00 78.24  ? 231 LEU R O   1 
ATOM   1605 C CB  . LEU A 1 369 ? 147.805 133.758 164.464 1.00 73.04  ? 231 LEU R CB  1 
ATOM   1606 C CG  . LEU A 1 369 ? 149.122 134.255 163.872 1.00 80.23  ? 231 LEU R CG  1 
ATOM   1607 C CD1 . LEU A 1 369 ? 148.980 135.696 163.412 1.00 81.46  ? 231 LEU R CD1 1 
ATOM   1608 C CD2 . LEU A 1 369 ? 150.246 134.120 164.885 1.00 76.25  ? 231 LEU R CD2 1 
ATOM   1609 N N   . LEU A 1 370 ? 146.592 132.831 161.225 1.00 76.38  ? 232 LEU R N   1 
ATOM   1610 C CA  . LEU A 1 370 ? 146.796 131.838 160.181 1.00 75.28  ? 232 LEU R CA  1 
ATOM   1611 C C   . LEU A 1 370 ? 148.271 131.470 160.079 1.00 77.36  ? 232 LEU R C   1 
ATOM   1612 O O   . LEU A 1 370 ? 149.156 132.262 160.416 1.00 76.72  ? 232 LEU R O   1 
ATOM   1613 C CB  . LEU A 1 370 ? 146.292 132.360 158.836 1.00 68.05  ? 232 LEU R CB  1 
ATOM   1614 C CG  . LEU A 1 370 ? 144.777 132.454 158.658 1.00 65.71  ? 232 LEU R CG  1 
ATOM   1615 C CD1 . LEU A 1 370 ? 144.437 133.074 157.315 1.00 68.47  ? 232 LEU R CD1 1 
ATOM   1616 C CD2 . LEU A 1 370 ? 144.139 131.085 158.791 1.00 73.30  ? 232 LEU R CD2 1 
ATOM   1617 N N   . SER A 1 371 ? 148.526 130.250 159.612 1.00 82.32  ? 233 SER R N   1 
ATOM   1618 C CA  . SER A 1 371 ? 149.880 129.691 159.504 1.00 80.98  ? 233 SER R CA  1 
ATOM   1619 C C   . SER A 1 371 ? 150.480 129.701 160.909 1.00 80.06  ? 233 SER R C   1 
ATOM   1620 O O   . SER A 1 371 ? 149.839 129.194 161.843 1.00 80.72  ? 233 SER R O   1 
ATOM   1621 C CB  . SER A 1 371 ? 150.667 130.448 158.441 1.00 82.14  ? 233 SER R CB  1 
ATOM   1622 O OG  . SER A 1 371 ? 150.202 130.129 157.142 1.00 87.03  ? 233 SER R OG  1 
ATOM   1623 N N   . GLY A 1 372 ? 151.671 130.255 161.113 1.00 85.19  ? 234 GLY R N   1 
ATOM   1624 C CA  . GLY A 1 372 ? 152.277 130.242 162.429 1.00 88.92  ? 234 GLY R CA  1 
ATOM   1625 C C   . GLY A 1 372 ? 152.981 131.529 162.804 1.00 90.22  ? 234 GLY R C   1 
ATOM   1626 O O   . GLY A 1 372 ? 153.615 131.607 163.860 1.00 91.40  ? 234 GLY R O   1 
ATOM   1627 N N   . SER A 1 373 ? 152.879 132.548 161.954 1.00 97.10  ? 235 SER R N   1 
ATOM   1628 C CA  . SER A 1 373 ? 153.527 133.824 162.211 1.00 95.96  ? 235 SER R CA  1 
ATOM   1629 C C   . SER A 1 373 ? 152.634 134.955 161.722 1.00 97.17  ? 235 SER R C   1 
ATOM   1630 O O   . SER A 1 373 ? 151.768 134.767 160.864 1.00 99.58  ? 235 SER R O   1 
ATOM   1631 C CB  . SER A 1 373 ? 154.905 133.905 161.541 1.00 96.57  ? 235 SER R CB  1 
ATOM   1632 O OG  . SER A 1 373 ? 154.783 133.981 160.132 1.00 94.59  ? 235 SER R OG  1 
ATOM   1633 N N   . ARG A 1 374 ? 152.859 136.142 162.290 1.00 95.71  ? 236 ARG R N   1 
ATOM   1634 C CA  . ARG A 1 374 ? 152.058 137.308 161.927 1.00 101.18 ? 236 ARG R CA  1 
ATOM   1635 C C   . ARG A 1 374 ? 152.281 137.709 160.473 1.00 104.62 ? 236 ARG R C   1 
ATOM   1636 O O   . ARG A 1 374 ? 151.331 138.088 159.773 1.00 107.84 ? 236 ARG R O   1 
ATOM   1637 C CB  . ARG A 1 374 ? 152.385 138.470 162.864 1.00 97.62  ? 236 ARG R CB  1 
ATOM   1638 C CG  . ARG A 1 374 ? 151.229 139.418 163.110 1.00 96.03  ? 236 ARG R CG  1 
ATOM   1639 C CD  . ARG A 1 374 ? 151.401 140.159 164.424 1.00 97.56  ? 236 ARG R CD  1 
ATOM   1640 N NE  . ARG A 1 374 ? 151.526 139.242 165.551 1.00 100.43 ? 236 ARG R NE  1 
ATOM   1641 C CZ  . ARG A 1 374 ? 151.485 139.609 166.824 1.00 100.85 ? 236 ARG R CZ  1 
ATOM   1642 N NH1 . ARG A 1 374 ? 151.321 140.875 167.174 1.00 99.90  ? 236 ARG R NH1 1 
ATOM   1643 N NH2 . ARG A 1 374 ? 151.611 138.684 167.771 1.00 97.23  ? 236 ARG R NH2 1 
ATOM   1644 N N   . GLU A 1 375 ? 153.530 137.639 160.002 1.00 96.81  ? 237 GLU R N   1 
ATOM   1645 C CA  . GLU A 1 375 ? 153.822 138.031 158.627 1.00 93.10  ? 237 GLU R CA  1 
ATOM   1646 C C   . GLU A 1 375 ? 153.125 137.114 157.629 1.00 94.29  ? 237 GLU R C   1 
ATOM   1647 O O   . GLU A 1 375 ? 152.591 137.582 156.616 1.00 95.81  ? 237 GLU R O   1 
ATOM   1648 C CB  . GLU A 1 375 ? 155.334 138.052 158.392 1.00 94.93  ? 237 GLU R CB  1 
ATOM   1649 C CG  . GLU A 1 375 ? 156.042 136.726 158.618 1.00 98.00  ? 237 GLU R CG  1 
ATOM   1650 C CD  . GLU A 1 375 ? 156.531 136.562 160.043 1.00 99.56  ? 237 GLU R CD  1 
ATOM   1651 O OE1 . GLU A 1 375 ? 156.082 137.331 160.919 1.00 100.71 ? 237 GLU R OE1 1 
ATOM   1652 O OE2 . GLU A 1 375 ? 157.366 135.666 160.287 1.00 96.48  ? 237 GLU R OE2 1 
ATOM   1653 N N   . LYS A 1 376 ? 153.108 135.807 157.900 1.00 83.17  ? 238 LYS R N   1 
ATOM   1654 C CA  . LYS A 1 376 ? 152.399 134.885 157.020 1.00 86.22  ? 238 LYS R CA  1 
ATOM   1655 C C   . LYS A 1 376 ? 150.906 135.185 157.004 1.00 85.58  ? 238 LYS R C   1 
ATOM   1656 O O   . LYS A 1 376 ? 150.270 135.162 155.944 1.00 91.08  ? 238 LYS R O   1 
ATOM   1657 C CB  . LYS A 1 376 ? 152.657 133.444 157.454 1.00 89.34  ? 238 LYS R CB  1 
ATOM   1658 C CG  . LYS A 1 376 ? 154.063 132.952 157.156 1.00 90.50  ? 238 LYS R CG  1 
ATOM   1659 C CD  . LYS A 1 376 ? 154.264 131.525 157.638 1.00 89.26  ? 238 LYS R CD  1 
ATOM   1660 C CE  . LYS A 1 376 ? 155.732 131.133 157.610 1.00 88.31  ? 238 LYS R CE  1 
ATOM   1661 N NZ  . LYS A 1 376 ? 155.958 129.795 158.222 1.00 89.85  ? 238 LYS R NZ  1 
ATOM   1662 N N   . ASP A 1 377 ? 150.335 135.480 158.172 1.00 72.39  ? 239 ASP R N   1 
ATOM   1663 C CA  . ASP A 1 377 ? 148.921 135.832 158.248 1.00 78.71  ? 239 ASP R CA  1 
ATOM   1664 C C   . ASP A 1 377 ? 148.608 137.052 157.388 1.00 85.68  ? 239 ASP R C   1 
ATOM   1665 O O   . ASP A 1 377 ? 147.690 137.022 156.554 1.00 83.92  ? 239 ASP R O   1 
ATOM   1666 C CB  . ASP A 1 377 ? 148.534 136.082 159.706 1.00 74.06  ? 239 ASP R CB  1 
ATOM   1667 C CG  . ASP A 1 377 ? 147.072 136.432 159.874 1.00 82.90  ? 239 ASP R CG  1 
ATOM   1668 O OD1 . ASP A 1 377 ? 146.264 136.079 158.991 1.00 93.56  ? 239 ASP R OD1 1 
ATOM   1669 O OD2 . ASP A 1 377 ? 146.731 137.069 160.892 1.00 80.16  ? 239 ASP R OD2 1 
ATOM   1670 N N   . ARG A 1 378 ? 149.367 138.137 157.573 1.00 90.42  ? 240 ARG R N   1 
ATOM   1671 C CA  . ARG A 1 378 ? 149.076 139.360 156.830 1.00 85.71  ? 240 ARG R CA  1 
ATOM   1672 C C   . ARG A 1 378 ? 149.313 139.171 155.337 1.00 84.97  ? 240 ARG R C   1 
ATOM   1673 O O   . ARG A 1 378 ? 148.565 139.713 154.513 1.00 89.20  ? 240 ARG R O   1 
ATOM   1674 C CB  . ARG A 1 378 ? 149.900 140.528 157.377 1.00 83.94  ? 240 ARG R CB  1 
ATOM   1675 C CG  . ARG A 1 378 ? 151.402 140.383 157.242 1.00 84.40  ? 240 ARG R CG  1 
ATOM   1676 C CD  . ARG A 1 378 ? 152.127 141.488 157.992 1.00 88.83  ? 240 ARG R CD  1 
ATOM   1677 N NE  . ARG A 1 378 ? 153.569 141.280 158.019 1.00 89.55  ? 240 ARG R NE  1 
ATOM   1678 C CZ  . ARG A 1 378 ? 154.416 141.791 157.136 1.00 90.37  ? 240 ARG R CZ  1 
ATOM   1679 N NH1 . ARG A 1 378 ? 153.997 142.542 156.131 1.00 89.08  ? 240 ARG R NH1 1 
ATOM   1680 N NH2 . ARG A 1 378 ? 155.716 141.541 157.264 1.00 89.13  ? 240 ARG R NH2 1 
ATOM   1681 N N   . ASN A 1 379 ? 150.334 138.390 154.966 1.00 75.63  ? 241 ASN R N   1 
ATOM   1682 C CA  . ASN A 1 379 ? 150.550 138.086 153.557 1.00 76.44  ? 241 ASN R CA  1 
ATOM   1683 C C   . ASN A 1 379 ? 149.359 137.342 152.971 1.00 76.12  ? 241 ASN R C   1 
ATOM   1684 O O   . ASN A 1 379 ? 148.917 137.644 151.855 1.00 80.03  ? 241 ASN R O   1 
ATOM   1685 C CB  . ASN A 1 379 ? 151.828 137.268 153.385 1.00 74.88  ? 241 ASN R CB  1 
ATOM   1686 C CG  . ASN A 1 379 ? 153.080 138.112 153.502 1.00 79.25  ? 241 ASN R CG  1 
ATOM   1687 O OD1 . ASN A 1 379 ? 153.065 139.308 153.215 1.00 81.67  ? 241 ASN R OD1 1 
ATOM   1688 N ND2 . ASN A 1 379 ? 154.176 137.490 153.923 1.00 82.50  ? 241 ASN R ND2 1 
ATOM   1689 N N   . LEU A 1 380 ? 148.822 136.369 153.710 1.00 70.04  ? 242 LEU R N   1 
ATOM   1690 C CA  . LEU A 1 380 ? 147.666 135.623 153.224 1.00 67.39  ? 242 LEU R CA  1 
ATOM   1691 C C   . LEU A 1 380 ? 146.464 136.538 153.018 1.00 68.22  ? 242 LEU R C   1 
ATOM   1692 O O   . LEU A 1 380 ? 145.794 136.470 151.981 1.00 68.96  ? 242 LEU R O   1 
ATOM   1693 C CB  . LEU A 1 380 ? 147.328 134.490 154.193 1.00 70.18  ? 242 LEU R CB  1 
ATOM   1694 C CG  . LEU A 1 380 ? 147.837 133.094 153.825 1.00 68.70  ? 242 LEU R CG  1 
ATOM   1695 C CD1 . LEU A 1 380 ? 149.354 133.045 153.775 1.00 70.89  ? 242 LEU R CD1 1 
ATOM   1696 C CD2 . LEU A 1 380 ? 147.306 132.063 154.807 1.00 67.98  ? 242 LEU R CD2 1 
ATOM   1697 N N   . ARG A 1 381 ? 146.184 137.415 153.987 1.00 64.58  ? 243 ARG R N   1 
ATOM   1698 C CA  . ARG A 1 381 ? 145.041 138.320 153.831 1.00 67.25  ? 243 ARG R CA  1 
ATOM   1699 C C   . ARG A 1 381 ? 145.226 139.246 152.632 1.00 72.84  ? 243 ARG R C   1 
ATOM   1700 O O   . ARG A 1 381 ? 144.293 139.451 151.833 1.00 76.13  ? 243 ARG R O   1 
ATOM   1701 C CB  . ARG A 1 381 ? 144.828 139.154 155.096 1.00 68.20  ? 243 ARG R CB  1 
ATOM   1702 C CG  . ARG A 1 381 ? 145.065 138.434 156.405 1.00 67.48  ? 243 ARG R CG  1 
ATOM   1703 C CD  . ARG A 1 381 ? 143.848 137.664 156.868 1.00 68.59  ? 243 ARG R CD  1 
ATOM   1704 N NE  . ARG A 1 381 ? 144.095 136.997 158.140 1.00 69.61  ? 243 ARG R NE  1 
ATOM   1705 C CZ  . ARG A 1 381 ? 143.265 137.021 159.173 1.00 65.77  ? 243 ARG R CZ  1 
ATOM   1706 N NH1 . ARG A 1 381 ? 142.115 137.670 159.120 1.00 67.50  ? 243 ARG R NH1 1 
ATOM   1707 N NH2 . ARG A 1 381 ? 143.598 136.377 160.287 1.00 64.98  ? 243 ARG R NH2 1 
ATOM   1708 N N   . ARG A 1 382 ? 146.426 139.822 152.500 1.00 71.64  ? 244 ARG R N   1 
ATOM   1709 C CA  . ARG A 1 382 ? 146.688 140.771 151.425 1.00 67.72  ? 244 ARG R CA  1 
ATOM   1710 C C   . ARG A 1 382 ? 146.581 140.105 150.061 1.00 70.52  ? 244 ARG R C   1 
ATOM   1711 O O   . ARG A 1 382 ? 146.060 140.701 149.113 1.00 73.87  ? 244 ARG R O   1 
ATOM   1712 C CB  . ARG A 1 382 ? 148.068 141.398 151.613 1.00 64.40  ? 244 ARG R CB  1 
ATOM   1713 C CG  . ARG A 1 382 ? 148.379 142.515 150.637 1.00 74.42  ? 244 ARG R CG  1 
ATOM   1714 C CD  . ARG A 1 382 ? 149.736 143.131 150.922 1.00 77.60  ? 244 ARG R CD  1 
ATOM   1715 N NE  . ARG A 1 382 ? 150.825 142.190 150.685 1.00 79.94  ? 244 ARG R NE  1 
ATOM   1716 C CZ  . ARG A 1 382 ? 151.633 141.728 151.629 1.00 78.28  ? 244 ARG R CZ  1 
ATOM   1717 N NH1 . ARG A 1 382 ? 151.501 142.096 152.892 1.00 74.93  ? 244 ARG R NH1 1 
ATOM   1718 N NH2 . ARG A 1 382 ? 152.599 140.877 151.296 1.00 76.54  ? 244 ARG R NH2 1 
ATOM   1719 N N   . ILE A 1 383 ? 147.084 138.875 149.935 1.00 62.66  ? 245 ILE R N   1 
ATOM   1720 C CA  . ILE A 1 383 ? 146.961 138.166 148.667 1.00 59.80  ? 245 ILE R CA  1 
ATOM   1721 C C   . ILE A 1 383 ? 145.513 137.769 148.403 1.00 54.79  ? 245 ILE R C   1 
ATOM   1722 O O   . ILE A 1 383 ? 145.072 137.737 147.248 1.00 53.40  ? 245 ILE R O   1 
ATOM   1723 C CB  . ILE A 1 383 ? 147.904 136.948 148.649 1.00 63.56  ? 245 ILE R CB  1 
ATOM   1724 C CG1 . ILE A 1 383 ? 149.361 137.405 148.735 1.00 62.31  ? 245 ILE R CG1 1 
ATOM   1725 C CG2 . ILE A 1 383 ? 147.698 136.118 147.395 1.00 59.17  ? 245 ILE R CG2 1 
ATOM   1726 C CD1 . ILE A 1 383 ? 150.352 136.269 148.809 1.00 58.50  ? 245 ILE R CD1 1 
ATOM   1727 N N   . THR A 1 384 ? 144.743 137.479 149.455 1.00 49.34  ? 246 THR R N   1 
ATOM   1728 C CA  . THR A 1 384 ? 143.396 136.958 149.252 1.00 50.57  ? 246 THR R CA  1 
ATOM   1729 C C   . THR A 1 384 ? 142.424 138.037 148.785 1.00 52.02  ? 246 THR R C   1 
ATOM   1730 O O   . THR A 1 384 ? 141.597 137.783 147.902 1.00 50.46  ? 246 THR R O   1 
ATOM   1731 C CB  . THR A 1 384 ? 142.885 136.310 150.539 1.00 57.11  ? 246 THR R CB  1 
ATOM   1732 O OG1 . THR A 1 384 ? 143.892 135.441 151.071 1.00 61.04  ? 246 THR R OG1 1 
ATOM   1733 C CG2 . THR A 1 384 ? 141.624 135.505 150.266 1.00 49.15  ? 246 THR R CG2 1 
ATOM   1734 N N   . ARG A 1 385 ? 142.495 139.240 149.364 1.00 57.96  ? 247 ARG R N   1 
ATOM   1735 C CA  . ARG A 1 385 ? 141.421 140.214 149.140 1.00 59.49  ? 247 ARG R CA  1 
ATOM   1736 C C   . ARG A 1 385 ? 141.222 140.617 147.673 1.00 55.87  ? 247 ARG R C   1 
ATOM   1737 O O   . ARG A 1 385 ? 140.059 140.655 147.218 1.00 53.26  ? 247 ARG R O   1 
ATOM   1738 C CB  . ARG A 1 385 ? 141.647 141.442 150.028 1.00 50.44  ? 247 ARG R CB  1 
ATOM   1739 C CG  . ARG A 1 385 ? 140.622 142.543 149.818 1.00 50.29  ? 247 ARG R CG  1 
ATOM   1740 C CD  . ARG A 1 385 ? 140.870 143.723 150.740 1.00 51.20  ? 247 ARG R CD  1 
ATOM   1741 N NE  . ARG A 1 385 ? 139.875 144.771 150.554 1.00 52.14  ? 247 ARG R NE  1 
ATOM   1742 C CZ  . ARG A 1 385 ? 139.995 145.773 149.694 1.00 55.64  ? 247 ARG R CZ  1 
ATOM   1743 N NH1 . ARG A 1 385 ? 141.060 145.896 148.921 1.00 60.14  ? 247 ARG R NH1 1 
ATOM   1744 N NH2 . ARG A 1 385 ? 139.021 146.674 149.608 1.00 53.57  ? 247 ARG R NH2 1 
ATOM   1745 N N   . PRO A 1 386 ? 142.267 140.949 146.894 1.00 52.51  ? 248 PRO R N   1 
ATOM   1746 C CA  . PRO A 1 386 ? 142.030 141.337 145.491 1.00 46.05  ? 248 PRO R CA  1 
ATOM   1747 C C   . PRO A 1 386 ? 141.268 140.304 144.681 1.00 50.31  ? 248 PRO R C   1 
ATOM   1748 O O   . PRO A 1 386 ? 140.469 140.678 143.817 1.00 58.27  ? 248 PRO R O   1 
ATOM   1749 C CB  . PRO A 1 386 ? 143.444 141.535 144.927 1.00 52.94  ? 248 PRO R CB  1 
ATOM   1750 C CG  . PRO A 1 386 ? 144.366 141.566 146.080 1.00 57.44  ? 248 PRO R CG  1 
ATOM   1751 C CD  . PRO A 1 386 ? 143.614 141.340 147.344 1.00 58.05  ? 248 PRO R CD  1 
ATOM   1752 N N   . THR A 1 387 ? 141.508 139.012 144.918 1.00 58.25  ? 249 THR R N   1 
ATOM   1753 C CA  . THR A 1 387 ? 140.770 137.985 144.190 1.00 59.50  ? 249 THR R CA  1 
ATOM   1754 C C   . THR A 1 387 ? 139.285 138.037 144.524 1.00 57.68  ? 249 THR R C   1 
ATOM   1755 O O   . THR A 1 387 ? 138.438 137.834 143.645 1.00 55.23  ? 249 THR R O   1 
ATOM   1756 C CB  . THR A 1 387 ? 141.342 136.602 144.498 1.00 53.88  ? 249 THR R CB  1 
ATOM   1757 O OG1 . THR A 1 387 ? 140.959 136.207 145.820 1.00 55.49  ? 249 THR R OG1 1 
ATOM   1758 C CG2 . THR A 1 387 ? 142.857 136.621 144.403 1.00 53.98  ? 249 THR R CG2 1 
ATOM   1759 N N   . VAL A 1 388 ? 138.951 138.311 145.787 1.00 47.68  ? 250 VAL R N   1 
ATOM   1760 C CA  . VAL A 1 388 ? 137.551 138.466 146.169 1.00 41.95  ? 250 VAL R CA  1 
ATOM   1761 C C   . VAL A 1 388 ? 136.924 139.623 145.407 1.00 53.14  ? 250 VAL R C   1 
ATOM   1762 O O   . VAL A 1 388 ? 135.819 139.505 144.857 1.00 57.93  ? 250 VAL R O   1 
ATOM   1763 C CB  . VAL A 1 388 ? 137.426 138.670 147.689 1.00 39.03  ? 250 VAL R CB  1 
ATOM   1764 C CG1 . VAL A 1 388 ? 135.981 138.525 148.121 1.00 40.44  ? 250 VAL R CG1 1 
ATOM   1765 C CG2 . VAL A 1 388 ? 138.314 137.695 148.431 1.00 48.83  ? 250 VAL R CG2 1 
ATOM   1766 N N   . ILE A 1 389 ? 137.626 140.759 145.355 1.00 52.41  ? 251 ILE R N   1 
ATOM   1767 C CA  . ILE A 1 389 ? 137.080 141.914 144.640 1.00 47.64  ? 251 ILE R CA  1 
ATOM   1768 C C   . ILE A 1 389 ? 136.897 141.592 143.160 1.00 50.46  ? 251 ILE R C   1 
ATOM   1769 O O   . ILE A 1 389 ? 135.872 141.936 142.554 1.00 48.89  ? 251 ILE R O   1 
ATOM   1770 C CB  . ILE A 1 389 ? 137.977 143.149 144.843 1.00 43.16  ? 251 ILE R CB  1 
ATOM   1771 C CG1 . ILE A 1 389 ? 138.001 143.549 146.317 1.00 51.94  ? 251 ILE R CG1 1 
ATOM   1772 C CG2 . ILE A 1 389 ? 137.482 144.308 143.998 1.00 40.65  ? 251 ILE R CG2 1 
ATOM   1773 C CD1 . ILE A 1 389 ? 136.645 143.932 146.860 1.00 51.19  ? 251 ILE R CD1 1 
ATOM   1774 N N   . LEU A 1 390 ? 137.884 140.924 142.559 1.00 51.63  ? 252 LEU R N   1 
ATOM   1775 C CA  . LEU A 1 390 ? 137.816 140.598 141.138 1.00 43.65  ? 252 LEU R CA  1 
ATOM   1776 C C   . LEU A 1 390 ? 136.646 139.675 140.834 1.00 44.90  ? 252 LEU R C   1 
ATOM   1777 O O   . LEU A 1 390 ? 135.909 139.893 139.865 1.00 53.89  ? 252 LEU R O   1 
ATOM   1778 C CB  . LEU A 1 390 ? 139.129 139.956 140.688 1.00 44.80  ? 252 LEU R CB  1 
ATOM   1779 C CG  . LEU A 1 390 ? 139.141 139.220 139.349 1.00 48.15  ? 252 LEU R CG  1 
ATOM   1780 C CD1 . LEU A 1 390 ? 138.927 140.189 138.204 1.00 51.53  ? 252 LEU R CD1 1 
ATOM   1781 C CD2 . LEU A 1 390 ? 140.447 138.468 139.176 1.00 43.07  ? 252 LEU R CD2 1 
ATOM   1782 N N   . ILE A 1 391 ? 136.457 138.638 141.652 1.00 43.76  ? 253 ILE R N   1 
ATOM   1783 C CA  . ILE A 1 391 ? 135.365 137.699 141.419 1.00 45.69  ? 253 ILE R CA  1 
ATOM   1784 C C   . ILE A 1 391 ? 134.019 138.391 141.586 1.00 47.16  ? 253 ILE R C   1 
ATOM   1785 O O   . ILE A 1 391 ? 133.092 138.179 140.789 1.00 47.84  ? 253 ILE R O   1 
ATOM   1786 C CB  . ILE A 1 391 ? 135.511 136.481 142.348 1.00 48.53  ? 253 ILE R CB  1 
ATOM   1787 C CG1 . ILE A 1 391 ? 136.576 135.534 141.794 1.00 52.91  ? 253 ILE R CG1 1 
ATOM   1788 C CG2 . ILE A 1 391 ? 134.186 135.760 142.506 1.00 41.94  ? 253 ILE R CG2 1 
ATOM   1789 C CD1 . ILE A 1 391 ? 137.339 134.786 142.847 1.00 45.60  ? 253 ILE R CD1 1 
ATOM   1790 N N   . LEU A 1 392 ? 133.886 139.234 142.615 1.00 45.14  ? 254 LEU R N   1 
ATOM   1791 C CA  . LEU A 1 392 ? 132.627 139.939 142.822 1.00 41.87  ? 254 LEU R CA  1 
ATOM   1792 C C   . LEU A 1 392 ? 132.305 140.848 141.641 1.00 46.64  ? 254 LEU R C   1 
ATOM   1793 O O   . LEU A 1 392 ? 131.168 140.873 141.156 1.00 54.67  ? 254 LEU R O   1 
ATOM   1794 C CB  . LEU A 1 392 ? 132.680 140.737 144.124 1.00 42.20  ? 254 LEU R CB  1 
ATOM   1795 C CG  . LEU A 1 392 ? 131.403 141.493 144.486 1.00 47.59  ? 254 LEU R CG  1 
ATOM   1796 C CD1 . LEU A 1 392 ? 130.238 140.530 144.622 1.00 51.94  ? 254 LEU R CD1 1 
ATOM   1797 C CD2 . LEU A 1 392 ? 131.598 142.283 145.768 1.00 51.51  ? 254 LEU R CD2 1 
ATOM   1798 N N   . ALA A 1 393 ? 133.302 141.593 141.152 1.00 40.44  ? 255 ALA R N   1 
ATOM   1799 C CA  . ALA A 1 393 ? 133.068 142.471 140.009 1.00 30.41  ? 255 ALA R CA  1 
ATOM   1800 C C   . ALA A 1 393 ? 132.714 141.676 138.758 1.00 31.02  ? 255 ALA R C   1 
ATOM   1801 O O   . ALA A 1 393 ? 131.809 142.057 138.006 1.00 32.63  ? 255 ALA R O   1 
ATOM   1802 C CB  . ALA A 1 393 ? 134.297 143.344 139.758 1.00 38.97  ? 255 ALA R CB  1 
ATOM   1803 N N   . PHE A 1 394 ? 133.418 140.566 138.522 1.00 42.43  ? 256 PHE R N   1 
ATOM   1804 C CA  . PHE A 1 394 ? 133.151 139.734 137.354 1.00 38.79  ? 256 PHE R CA  1 
ATOM   1805 C C   . PHE A 1 394 ? 131.715 139.226 137.359 1.00 39.90  ? 256 PHE R C   1 
ATOM   1806 O O   . PHE A 1 394 ? 131.000 139.324 136.351 1.00 46.46  ? 256 PHE R O   1 
ATOM   1807 C CB  . PHE A 1 394 ? 134.145 138.570 137.332 1.00 38.05  ? 256 PHE R CB  1 
ATOM   1808 C CG  . PHE A 1 394 ? 134.078 137.719 136.097 1.00 38.45  ? 256 PHE R CG  1 
ATOM   1809 C CD1 . PHE A 1 394 ? 133.202 136.650 136.021 1.00 35.13  ? 256 PHE R CD1 1 
ATOM   1810 C CD2 . PHE A 1 394 ? 134.914 137.969 135.024 1.00 43.04  ? 256 PHE R CD2 1 
ATOM   1811 C CE1 . PHE A 1 394 ? 133.149 135.860 134.893 1.00 36.64  ? 256 PHE R CE1 1 
ATOM   1812 C CE2 . PHE A 1 394 ? 134.864 137.183 133.893 1.00 40.94  ? 256 PHE R CE2 1 
ATOM   1813 C CZ  . PHE A 1 394 ? 133.981 136.127 133.827 1.00 39.83  ? 256 PHE R CZ  1 
ATOM   1814 N N   . PHE A 1 395 ? 131.268 138.692 138.496 1.00 44.11  ? 257 PHE R N   1 
ATOM   1815 C CA  . PHE A 1 395 ? 129.918 138.144 138.549 1.00 43.39  ? 257 PHE R CA  1 
ATOM   1816 C C   . PHE A 1 395 ? 128.865 139.245 138.497 1.00 42.79  ? 257 PHE R C   1 
ATOM   1817 O O   . PHE A 1 395 ? 127.805 139.063 137.888 1.00 46.27  ? 257 PHE R O   1 
ATOM   1818 C CB  . PHE A 1 395 ? 129.753 137.269 139.788 1.00 42.95  ? 257 PHE R CB  1 
ATOM   1819 C CG  . PHE A 1 395 ? 130.244 135.866 139.592 1.00 44.91  ? 257 PHE R CG  1 
ATOM   1820 C CD1 . PHE A 1 395 ? 129.437 134.915 138.994 1.00 43.26  ? 257 PHE R CD1 1 
ATOM   1821 C CD2 . PHE A 1 395 ? 131.523 135.504 139.978 1.00 50.78  ? 257 PHE R CD2 1 
ATOM   1822 C CE1 . PHE A 1 395 ? 129.889 133.626 138.800 1.00 39.68  ? 257 PHE R CE1 1 
ATOM   1823 C CE2 . PHE A 1 395 ? 131.981 134.217 139.785 1.00 53.57  ? 257 PHE R CE2 1 
ATOM   1824 C CZ  . PHE A 1 395 ? 131.163 133.277 139.196 1.00 44.86  ? 257 PHE R CZ  1 
ATOM   1825 N N   . ALA A 1 396 ? 129.142 140.402 139.107 1.00 40.28  ? 258 ALA R N   1 
ATOM   1826 C CA  . ALA A 1 396 ? 128.200 141.512 139.020 1.00 35.43  ? 258 ALA R CA  1 
ATOM   1827 C C   . ALA A 1 396 ? 128.056 142.012 137.591 1.00 45.01  ? 258 ALA R C   1 
ATOM   1828 O O   . ALA A 1 396 ? 126.970 142.447 137.193 1.00 49.37  ? 258 ALA R O   1 
ATOM   1829 C CB  . ALA A 1 396 ? 128.637 142.650 139.940 1.00 43.20  ? 258 ALA R CB  1 
ATOM   1830 N N   . CYS A 1 397 ? 129.136 141.971 136.808 1.00 59.57  ? 259 CYS R N   1 
ATOM   1831 C CA  . CYS A 1 397 ? 129.030 142.338 135.399 1.00 51.00  ? 259 CYS R CA  1 
ATOM   1832 C C   . CYS A 1 397 ? 128.245 141.297 134.610 1.00 47.23  ? 259 CYS R C   1 
ATOM   1833 O O   . CYS A 1 397 ? 127.371 141.648 133.809 1.00 41.58  ? 259 CYS R O   1 
ATOM   1834 C CB  . CYS A 1 397 ? 130.419 142.527 134.790 1.00 46.71  ? 259 CYS R CB  1 
ATOM   1835 S SG  . CYS A 1 397 ? 131.338 143.943 135.425 1.00 70.26  ? 259 CYS R SG  1 
ATOM   1836 N N   . TRP A 1 398 ? 128.539 140.011 134.820 1.00 48.18  ? 260 TRP R N   1 
ATOM   1837 C CA  . TRP A 1 398 ? 127.965 138.977 133.963 1.00 45.88  ? 260 TRP R CA  1 
ATOM   1838 C C   . TRP A 1 398 ? 126.536 138.583 134.328 1.00 45.80  ? 260 TRP R C   1 
ATOM   1839 O O   . TRP A 1 398 ? 125.851 137.987 133.491 1.00 46.19  ? 260 TRP R O   1 
ATOM   1840 C CB  . TRP A 1 398 ? 128.845 137.727 133.983 1.00 43.62  ? 260 TRP R CB  1 
ATOM   1841 C CG  . TRP A 1 398 ? 129.819 137.651 132.847 1.00 40.14  ? 260 TRP R CG  1 
ATOM   1842 C CD1 . TRP A 1 398 ? 131.177 137.687 132.934 1.00 46.51  ? 260 TRP R CD1 1 
ATOM   1843 C CD2 . TRP A 1 398 ? 129.511 137.516 131.454 1.00 47.42  ? 260 TRP R CD2 1 
ATOM   1844 N NE1 . TRP A 1 398 ? 131.737 137.586 131.685 1.00 48.71  ? 260 TRP R NE1 1 
ATOM   1845 C CE2 . TRP A 1 398 ? 130.734 137.480 130.758 1.00 53.45  ? 260 TRP R CE2 1 
ATOM   1846 C CE3 . TRP A 1 398 ? 128.321 137.425 130.728 1.00 50.89  ? 260 TRP R CE3 1 
ATOM   1847 C CZ2 . TRP A 1 398 ? 130.801 137.357 129.373 1.00 55.38  ? 260 TRP R CZ2 1 
ATOM   1848 C CZ3 . TRP A 1 398 ? 128.391 137.302 129.354 1.00 47.86  ? 260 TRP R CZ3 1 
ATOM   1849 C CH2 . TRP A 1 398 ? 129.620 137.269 128.691 1.00 50.90  ? 260 TRP R CH2 1 
ATOM   1850 N N   . LEU A 1 399 ? 126.069 138.887 135.540 1.00 43.41  ? 261 LEU R N   1 
ATOM   1851 C CA  . LEU A 1 399 ? 124.777 138.360 135.983 1.00 43.30  ? 261 LEU R CA  1 
ATOM   1852 C C   . LEU A 1 399 ? 123.580 138.848 135.170 1.00 55.57  ? 261 LEU R C   1 
ATOM   1853 O O   . LEU A 1 399 ? 122.750 138.006 134.777 1.00 66.40  ? 261 LEU R O   1 
ATOM   1854 C CB  . LEU A 1 399 ? 124.590 138.665 137.472 1.00 39.61  ? 261 LEU R CB  1 
ATOM   1855 C CG  . LEU A 1 399 ? 123.675 137.701 138.225 1.00 48.80  ? 261 LEU R CG  1 
ATOM   1856 C CD1 . LEU A 1 399 ? 124.413 136.414 138.548 1.00 48.55  ? 261 LEU R CD1 1 
ATOM   1857 C CD2 . LEU A 1 399 ? 123.141 138.346 139.491 1.00 54.56  ? 261 LEU R CD2 1 
ATOM   1858 N N   . PRO A 1 400 ? 123.398 140.150 134.908 1.00 47.92  ? 262 PRO R N   1 
ATOM   1859 C CA  . PRO A 1 400 ? 122.161 140.578 134.228 1.00 47.00  ? 262 PRO R CA  1 
ATOM   1860 C C   . PRO A 1 400 ? 121.981 139.974 132.846 1.00 52.25  ? 262 PRO R C   1 
ATOM   1861 O O   . PRO A 1 400 ? 120.842 139.722 132.433 1.00 57.73  ? 262 PRO R O   1 
ATOM   1862 C CB  . PRO A 1 400 ? 122.303 142.105 134.167 1.00 41.15  ? 262 PRO R CB  1 
ATOM   1863 C CG  . PRO A 1 400 ? 123.296 142.443 135.212 1.00 51.35  ? 262 PRO R CG  1 
ATOM   1864 C CD  . PRO A 1 400 ? 124.254 141.303 135.231 1.00 50.29  ? 262 PRO R CD  1 
ATOM   1865 N N   . TYR A 1 401 ? 123.070 139.728 132.116 1.00 49.83  ? 263 TYR R N   1 
ATOM   1866 C CA  . TYR A 1 401 ? 122.946 139.062 130.825 1.00 42.50  ? 263 TYR R CA  1 
ATOM   1867 C C   . TYR A 1 401 ? 122.399 137.653 130.991 1.00 48.25  ? 263 TYR R C   1 
ATOM   1868 O O   . TYR A 1 401 ? 121.563 137.203 130.197 1.00 60.99  ? 263 TYR R O   1 
ATOM   1869 C CB  . TYR A 1 401 ? 124.299 139.025 130.120 1.00 46.75  ? 263 TYR R CB  1 
ATOM   1870 C CG  . TYR A 1 401 ? 124.283 138.245 128.830 1.00 44.27  ? 263 TYR R CG  1 
ATOM   1871 C CD1 . TYR A 1 401 ? 123.425 138.592 127.799 1.00 47.51  ? 263 TYR R CD1 1 
ATOM   1872 C CD2 . TYR A 1 401 ? 125.116 137.154 128.649 1.00 47.19  ? 263 TYR R CD2 1 
ATOM   1873 C CE1 . TYR A 1 401 ? 123.407 137.881 126.619 1.00 52.75  ? 263 TYR R CE1 1 
ATOM   1874 C CE2 . TYR A 1 401 ? 125.104 136.436 127.474 1.00 53.16  ? 263 TYR R CE2 1 
ATOM   1875 C CZ  . TYR A 1 401 ? 124.247 136.803 126.463 1.00 57.09  ? 263 TYR R CZ  1 
ATOM   1876 O OH  . TYR A 1 401 ? 124.232 136.087 125.289 1.00 61.97  ? 263 TYR R OH  1 
ATOM   1877 N N   . TYR A 1 402 ? 122.866 136.940 132.016 1.00 46.54  ? 264 TYR R N   1 
ATOM   1878 C CA  . TYR A 1 402 ? 122.366 135.594 132.264 1.00 46.43  ? 264 TYR R CA  1 
ATOM   1879 C C   . TYR A 1 402 ? 120.902 135.621 132.674 1.00 45.57  ? 264 TYR R C   1 
ATOM   1880 O O   . TYR A 1 402 ? 120.129 134.745 132.278 1.00 51.32  ? 264 TYR R O   1 
ATOM   1881 C CB  . TYR A 1 402 ? 123.226 134.904 133.320 1.00 46.49  ? 264 TYR R CB  1 
ATOM   1882 C CG  . TYR A 1 402 ? 124.553 134.435 132.772 1.00 48.52  ? 264 TYR R CG  1 
ATOM   1883 C CD1 . TYR A 1 402 ? 124.617 133.715 131.590 1.00 47.17  ? 264 TYR R CD1 1 
ATOM   1884 C CD2 . TYR A 1 402 ? 125.740 134.726 133.425 1.00 47.54  ? 264 TYR R CD2 1 
ATOM   1885 C CE1 . TYR A 1 402 ? 125.823 133.289 131.077 1.00 46.80  ? 264 TYR R CE1 1 
ATOM   1886 C CE2 . TYR A 1 402 ? 126.953 134.302 132.919 1.00 51.35  ? 264 TYR R CE2 1 
ATOM   1887 C CZ  . TYR A 1 402 ? 126.987 133.584 131.745 1.00 53.82  ? 264 TYR R CZ  1 
ATOM   1888 O OH  . TYR A 1 402 ? 128.191 133.160 131.235 1.00 55.73  ? 264 TYR R OH  1 
ATOM   1889 N N   . ILE A 1 403 ? 120.493 136.634 133.443 1.00 33.59  ? 265 ILE R N   1 
ATOM   1890 C CA  . ILE A 1 403 ? 119.075 136.777 133.770 1.00 41.31  ? 265 ILE R CA  1 
ATOM   1891 C C   . ILE A 1 403 ? 118.256 137.001 132.503 1.00 42.18  ? 265 ILE R C   1 
ATOM   1892 O O   . ILE A 1 403 ? 117.189 136.397 132.312 1.00 45.38  ? 265 ILE R O   1 
ATOM   1893 C CB  . ILE A 1 403 ? 118.872 137.918 134.782 1.00 34.98  ? 265 ILE R CB  1 
ATOM   1894 C CG1 . ILE A 1 403 ? 119.424 137.522 136.151 1.00 40.16  ? 265 ILE R CG1 1 
ATOM   1895 C CG2 . ILE A 1 403 ? 117.401 138.284 134.888 1.00 39.52  ? 265 ILE R CG2 1 
ATOM   1896 C CD1 . ILE A 1 403 ? 119.309 138.612 137.190 1.00 46.46  ? 265 ILE R CD1 1 
ATOM   1897 N N   . GLY A 1 404 ? 118.747 137.867 131.615 1.00 37.81  ? 266 GLY R N   1 
ATOM   1898 C CA  . GLY A 1 404 ? 118.028 138.134 130.380 1.00 34.39  ? 266 GLY R CA  1 
ATOM   1899 C C   . GLY A 1 404 ? 117.880 136.900 129.512 1.00 51.08  ? 266 GLY R C   1 
ATOM   1900 O O   . GLY A 1 404 ? 116.795 136.610 129.002 1.00 62.17  ? 266 GLY R O   1 
ATOM   1901 N N   . ILE A 1 405 ? 118.969 136.146 129.337 1.00 57.95  ? 267 ILE R N   1 
ATOM   1902 C CA  . ILE A 1 405 ? 118.875 134.971 128.475 1.00 43.92  ? 267 ILE R CA  1 
ATOM   1903 C C   . ILE A 1 405 ? 118.092 133.856 129.156 1.00 52.83  ? 267 ILE R C   1 
ATOM   1904 O O   . ILE A 1 405 ? 117.489 133.021 128.477 1.00 58.18  ? 267 ILE R O   1 
ATOM   1905 C CB  . ILE A 1 405 ? 120.260 134.480 128.018 1.00 35.25  ? 267 ILE R CB  1 
ATOM   1906 C CG1 . ILE A 1 405 ? 121.164 134.186 129.209 1.00 43.24  ? 267 ILE R CG1 1 
ATOM   1907 C CG2 . ILE A 1 405 ? 120.896 135.487 127.084 1.00 49.37  ? 267 ILE R CG2 1 
ATOM   1908 C CD1 . ILE A 1 405 ? 122.526 133.680 128.804 1.00 47.95  ? 267 ILE R CD1 1 
ATOM   1909 N N   . SER A 1 406 ? 118.067 133.818 130.491 1.00 53.53  ? 268 SER R N   1 
ATOM   1910 C CA  . SER A 1 406 ? 117.193 132.869 131.172 1.00 53.10  ? 268 SER R CA  1 
ATOM   1911 C C   . SER A 1 406 ? 115.730 133.187 130.898 1.00 53.87  ? 268 SER R C   1 
ATOM   1912 O O   . SER A 1 406 ? 114.933 132.286 130.605 1.00 60.06  ? 268 SER R O   1 
ATOM   1913 C CB  . SER A 1 406 ? 117.472 132.880 132.674 1.00 48.27  ? 268 SER R CB  1 
ATOM   1914 O OG  . SER A 1 406 ? 118.805 132.485 132.947 1.00 52.95  ? 268 SER R OG  1 
ATOM   1915 N N   . ILE A 1 407 ? 115.363 134.468 130.970 1.00 51.02  ? 269 ILE R N   1 
ATOM   1916 C CA  . ILE A 1 407 ? 113.996 134.857 130.633 1.00 49.58  ? 269 ILE R CA  1 
ATOM   1917 C C   . ILE A 1 407 ? 113.693 134.519 129.178 1.00 60.08  ? 269 ILE R C   1 
ATOM   1918 O O   . ILE A 1 407 ? 112.607 134.026 128.853 1.00 70.65  ? 269 ILE R O   1 
ATOM   1919 C CB  . ILE A 1 407 ? 113.767 136.349 130.931 1.00 55.63  ? 269 ILE R CB  1 
ATOM   1920 C CG1 . ILE A 1 407 ? 113.722 136.587 132.440 1.00 59.31  ? 269 ILE R CG1 1 
ATOM   1921 C CG2 . ILE A 1 407 ? 112.476 136.828 130.294 1.00 55.58  ? 269 ILE R CG2 1 
ATOM   1922 C CD1 . ILE A 1 407 ? 113.856 138.042 132.832 1.00 58.02  ? 269 ILE R CD1 1 
ATOM   1923 N N   . ASP A 1 408 ? 114.650 134.761 128.281 1.00 59.99  ? 270 ASP R N   1 
ATOM   1924 C CA  . ASP A 1 408 ? 114.438 134.446 126.871 1.00 52.23  ? 270 ASP R CA  1 
ATOM   1925 C C   . ASP A 1 408 ? 114.221 132.951 126.660 1.00 58.96  ? 270 ASP R C   1 
ATOM   1926 O O   . ASP A 1 408 ? 113.323 132.536 125.919 1.00 62.54  ? 270 ASP R O   1 
ATOM   1927 C CB  . ASP A 1 408 ? 115.620 134.921 126.036 1.00 51.23  ? 270 ASP R CB  1 
ATOM   1928 C CG  . ASP A 1 408 ? 115.356 134.790 124.559 1.00 68.40  ? 270 ASP R CG  1 
ATOM   1929 O OD1 . ASP A 1 408 ? 114.234 135.126 124.131 1.00 68.14  ? 270 ASP R OD1 1 
ATOM   1930 O OD2 . ASP A 1 408 ? 116.244 134.301 123.836 1.00 74.75  ? 270 ASP R OD2 1 
ATOM   1931 N N   . SER A 1 409 ? 115.058 132.125 127.288 1.00 58.39  ? 271 SER R N   1 
ATOM   1932 C CA  . SER A 1 409 ? 114.920 130.682 127.146 1.00 57.46  ? 271 SER R CA  1 
ATOM   1933 C C   . SER A 1 409 ? 113.581 130.212 127.688 1.00 62.19  ? 271 SER R C   1 
ATOM   1934 O O   . SER A 1 409 ? 112.949 129.316 127.118 1.00 71.79  ? 271 SER R O   1 
ATOM   1935 C CB  . SER A 1 409 ? 116.070 129.971 127.858 1.00 64.04  ? 271 SER R CB  1 
ATOM   1936 O OG  . SER A 1 409 ? 117.283 130.129 127.144 1.00 72.72  ? 271 SER R OG  1 
ATOM   1937 N N   . PHE A 1 410 ? 113.128 130.808 128.792 1.00 60.85  ? 272 PHE R N   1 
ATOM   1938 C CA  . PHE A 1 410 ? 111.800 130.480 129.293 1.00 61.15  ? 272 PHE R CA  1 
ATOM   1939 C C   . PHE A 1 410 ? 110.700 131.016 128.387 1.00 59.10  ? 272 PHE R C   1 
ATOM   1940 O O   . PHE A 1 410 ? 109.557 130.563 128.490 1.00 63.27  ? 272 PHE R O   1 
ATOM   1941 C CB  . PHE A 1 410 ? 111.636 131.008 130.716 1.00 61.65  ? 272 PHE R CB  1 
ATOM   1942 C CG  . PHE A 1 410 ? 112.350 130.183 131.744 1.00 60.98  ? 272 PHE R CG  1 
ATOM   1943 C CD1 . PHE A 1 410 ? 112.316 128.802 131.682 1.00 57.76  ? 272 PHE R CD1 1 
ATOM   1944 C CD2 . PHE A 1 410 ? 113.073 130.784 132.757 1.00 66.51  ? 272 PHE R CD2 1 
ATOM   1945 C CE1 . PHE A 1 410 ? 112.976 128.037 132.617 1.00 61.46  ? 272 PHE R CE1 1 
ATOM   1946 C CE2 . PHE A 1 410 ? 113.737 130.024 133.697 1.00 64.63  ? 272 PHE R CE2 1 
ATOM   1947 C CZ  . PHE A 1 410 ? 113.688 128.648 133.626 1.00 64.51  ? 272 PHE R CZ  1 
ATOM   1948 N N   . ILE A 1 411 ? 111.007 131.994 127.533 1.00 60.15  ? 273 ILE R N   1 
ATOM   1949 C CA  . ILE A 1 411 ? 110.065 132.369 126.481 1.00 56.91  ? 273 ILE R CA  1 
ATOM   1950 C C   . ILE A 1 411 ? 110.025 131.298 125.395 1.00 57.52  ? 273 ILE R C   1 
ATOM   1951 O O   . ILE A 1 411 ? 108.955 130.973 124.867 1.00 65.13  ? 273 ILE R O   1 
ATOM   1952 C CB  . ILE A 1 411 ? 110.407 133.754 125.899 1.00 62.70  ? 273 ILE R CB  1 
ATOM   1953 C CG1 . ILE A 1 411 ? 110.284 134.839 126.970 1.00 64.64  ? 273 ILE R CG1 1 
ATOM   1954 C CG2 . ILE A 1 411 ? 109.497 134.079 124.725 1.00 64.57  ? 273 ILE R CG2 1 
ATOM   1955 C CD1 . ILE A 1 411 ? 110.222 136.246 126.418 1.00 53.60  ? 273 ILE R CD1 1 
ATOM   1956 N N   . LEU A 1 412 ? 111.187 130.743 125.036 1.00 70.57  ? 274 LEU R N   1 
ATOM   1957 C CA  . LEU A 1 412 ? 111.229 129.661 124.051 1.00 75.18  ? 274 LEU R CA  1 
ATOM   1958 C C   . LEU A 1 412 ? 110.359 128.487 124.482 1.00 77.52  ? 274 LEU R C   1 
ATOM   1959 O O   . LEU A 1 412 ? 109.377 128.145 123.814 1.00 74.81  ? 274 LEU R O   1 
ATOM   1960 C CB  . LEU A 1 412 ? 112.670 129.198 123.823 1.00 75.50  ? 274 LEU R CB  1 
ATOM   1961 C CG  . LEU A 1 412 ? 113.607 130.087 123.015 1.00 75.19  ? 274 LEU R CG  1 
ATOM   1962 C CD1 . LEU A 1 412 ? 115.021 129.547 123.070 1.00 68.88  ? 274 LEU R CD1 1 
ATOM   1963 C CD2 . LEU A 1 412 ? 113.121 130.110 121.582 1.00 72.32  ? 274 LEU R CD2 1 
ATOM   1964 N N   . LEU A 1 413 ? 110.718 127.846 125.591 1.00 75.06  ? 275 LEU R N   1 
ATOM   1965 C CA  . LEU A 1 413 ? 109.856 126.827 126.170 1.00 69.94  ? 275 LEU R CA  1 
ATOM   1966 C C   . LEU A 1 413 ? 108.527 127.460 126.553 1.00 69.83  ? 275 LEU R C   1 
ATOM   1967 O O   . LEU A 1 413 ? 108.494 128.524 127.175 1.00 75.23  ? 275 LEU R O   1 
ATOM   1968 C CB  . LEU A 1 413 ? 110.531 126.200 127.389 1.00 71.50  ? 275 LEU R CB  1 
ATOM   1969 C CG  . LEU A 1 413 ? 112.029 125.922 127.228 1.00 70.57  ? 275 LEU R CG  1 
ATOM   1970 C CD1 . LEU A 1 413 ? 112.672 125.586 128.565 1.00 70.73  ? 275 LEU R CD1 1 
ATOM   1971 C CD2 . LEU A 1 413 ? 112.268 124.809 126.221 1.00 74.96  ? 275 LEU R CD2 1 
ATOM   1972 N N   . GLU A 1 414 ? 107.426 126.810 126.184 1.00 81.24  ? 276 GLU R N   1 
ATOM   1973 C CA  . GLU A 1 414 ? 106.112 127.447 126.274 1.00 83.77  ? 276 GLU R CA  1 
ATOM   1974 C C   . GLU A 1 414 ? 105.713 127.558 127.743 1.00 86.38  ? 276 GLU R C   1 
ATOM   1975 O O   . GLU A 1 414 ? 104.910 126.786 128.272 1.00 91.71  ? 276 GLU R O   1 
ATOM   1976 C CB  . GLU A 1 414 ? 105.080 126.671 125.466 1.00 89.54  ? 276 GLU R CB  1 
ATOM   1977 C CG  . GLU A 1 414 ? 105.132 126.954 123.972 1.00 91.43  ? 276 GLU R CG  1 
ATOM   1978 C CD  . GLU A 1 414 ? 104.801 128.397 123.638 1.00 91.13  ? 276 GLU R CD  1 
ATOM   1979 O OE1 . GLU A 1 414 ? 104.003 129.014 124.374 1.00 90.55  ? 276 GLU R OE1 1 
ATOM   1980 O OE2 . GLU A 1 414 ? 105.341 128.915 122.638 1.00 89.93  ? 276 GLU R OE2 1 
ATOM   1981 N N   . ILE A 1 415 ? 106.295 128.553 128.411 1.00 84.82  ? 277 ILE R N   1 
ATOM   1982 C CA  . ILE A 1 415 ? 106.010 128.835 129.812 1.00 88.83  ? 277 ILE R CA  1 
ATOM   1983 C C   . ILE A 1 415 ? 105.603 130.295 129.952 1.00 86.08  ? 277 ILE R C   1 
ATOM   1984 O O   . ILE A 1 415 ? 104.537 130.608 130.494 1.00 87.94  ? 277 ILE R O   1 
ATOM   1985 C CB  . ILE A 1 415 ? 107.222 128.511 130.704 1.00 90.14  ? 277 ILE R CB  1 
ATOM   1986 C CG1 . ILE A 1 415 ? 107.421 126.997 130.806 1.00 89.73  ? 277 ILE R CG1 1 
ATOM   1987 C CG2 . ILE A 1 415 ? 107.048 129.122 132.086 1.00 83.53  ? 277 ILE R CG2 1 
ATOM   1988 C CD1 . ILE A 1 415 ? 108.697 126.593 131.510 1.00 89.45  ? 277 ILE R CD1 1 
ATOM   1989 N N   . ILE A 1 416 ? 106.448 131.195 129.460 1.00 78.23  ? 278 ILE R N   1 
ATOM   1990 C CA  . ILE A 1 416 ? 106.218 132.631 129.560 1.00 77.47  ? 278 ILE R CA  1 
ATOM   1991 C C   . ILE A 1 416 ? 105.446 133.091 128.331 1.00 76.53  ? 278 ILE R C   1 
ATOM   1992 O O   . ILE A 1 416 ? 105.842 132.804 127.195 1.00 80.66  ? 278 ILE R O   1 
ATOM   1993 C CB  . ILE A 1 416 ? 107.549 133.389 129.693 1.00 78.06  ? 278 ILE R CB  1 
ATOM   1994 C CG1 . ILE A 1 416 ? 108.073 133.307 131.128 1.00 78.74  ? 278 ILE R CG1 1 
ATOM   1995 C CG2 . ILE A 1 416 ? 107.390 134.836 129.268 1.00 78.54  ? 278 ILE R CG2 1 
ATOM   1996 C CD1 . ILE A 1 416 ? 109.356 134.079 131.356 1.00 72.76  ? 278 ILE R CD1 1 
ATOM   1997 N N   . LYS A 1 417 ? 104.340 133.804 128.553 1.00 86.89  ? 279 LYS R N   1 
ATOM   1998 C CA  . LYS A 1 417 ? 103.504 134.268 127.445 1.00 88.42  ? 279 LYS R CA  1 
ATOM   1999 C C   . LYS A 1 417 ? 102.804 135.561 127.861 1.00 90.67  ? 279 LYS R C   1 
ATOM   2000 O O   . LYS A 1 417 ? 101.933 135.553 128.736 1.00 91.45  ? 279 LYS R O   1 
ATOM   2001 C CB  . LYS A 1 417 ? 102.514 133.188 127.021 1.00 87.38  ? 279 LYS R CB  1 
ATOM   2002 C CG  . LYS A 1 417 ? 101.627 132.646 128.135 1.00 90.58  ? 279 LYS R CG  1 
ATOM   2003 C CD  . LYS A 1 417 ? 100.699 131.557 127.626 1.00 93.16  ? 279 LYS R CD  1 
ATOM   2004 C CE  . LYS A 1 417 ? 99.801  131.039 128.737 1.00 92.73  ? 279 LYS R CE  1 
ATOM   2005 N NZ  . LYS A 1 417 ? 100.571 130.304 129.778 1.00 89.42  ? 279 LYS R NZ  1 
ATOM   2006 N N   . GLN A 1 418 ? 103.207 136.670 127.240 1.00 95.69  ? 280 GLN R N   1 
ATOM   2007 C CA  . GLN A 1 418 ? 102.534 137.953 127.411 1.00 94.16  ? 280 GLN R CA  1 
ATOM   2008 C C   . GLN A 1 418 ? 102.391 138.650 126.064 1.00 98.22  ? 280 GLN R C   1 
ATOM   2009 O O   . GLN A 1 418 ? 102.595 138.031 125.015 1.00 97.88  ? 280 GLN R O   1 
ATOM   2010 C CB  . GLN A 1 418 ? 103.282 138.855 128.395 1.00 93.61  ? 280 GLN R CB  1 
ATOM   2011 C CG  . GLN A 1 418 ? 103.275 138.378 129.840 1.00 94.66  ? 280 GLN R CG  1 
ATOM   2012 C CD  . GLN A 1 418 ? 104.331 137.333 130.114 1.00 95.70  ? 280 GLN R CD  1 
ATOM   2013 O OE1 . GLN A 1 418 ? 105.267 137.167 129.336 1.00 96.78  ? 280 GLN R OE1 1 
ATOM   2014 N NE2 . GLN A 1 418 ? 104.190 136.625 131.229 1.00 95.69  ? 280 GLN R NE2 1 
ATOM   2015 N N   . GLY A 1 419 ? 102.039 139.932 126.083 1.00 109.68 ? 281 GLY R N   1 
ATOM   2016 C CA  . GLY A 1 419 ? 101.853 140.675 124.855 1.00 110.85 ? 281 GLY R CA  1 
ATOM   2017 C C   . GLY A 1 419 ? 103.140 140.833 124.065 1.00 111.70 ? 281 GLY R C   1 
ATOM   2018 O O   . GLY A 1 419 ? 104.251 140.669 124.570 1.00 111.82 ? 281 GLY R O   1 
ATOM   2019 N N   . CYS A 1 420 ? 102.971 141.169 122.783 1.00 109.62 ? 282 CYS R N   1 
ATOM   2020 C CA  . CYS A 1 420 ? 104.106 141.268 121.871 1.00 107.21 ? 282 CYS R CA  1 
ATOM   2021 C C   . CYS A 1 420 ? 105.106 142.335 122.296 1.00 109.38 ? 282 CYS R C   1 
ATOM   2022 O O   . CYS A 1 420 ? 106.260 142.293 121.858 1.00 109.10 ? 282 CYS R O   1 
ATOM   2023 C CB  . CYS A 1 420 ? 103.614 141.553 120.451 1.00 106.86 ? 282 CYS R CB  1 
ATOM   2024 S SG  . CYS A 1 420 ? 104.854 141.292 119.161 1.00 112.12 ? 282 CYS R SG  1 
ATOM   2025 N N   . GLU A 1 421 ? 104.692 143.290 123.132 1.00 108.07 ? 283 GLU R N   1 
ATOM   2026 C CA  . GLU A 1 421 ? 105.634 144.276 123.649 1.00 106.00 ? 283 GLU R CA  1 
ATOM   2027 C C   . GLU A 1 421 ? 106.716 143.621 124.498 1.00 104.04 ? 283 GLU R C   1 
ATOM   2028 O O   . GLU A 1 421 ? 107.855 144.106 124.539 1.00 103.36 ? 283 GLU R O   1 
ATOM   2029 C CB  . GLU A 1 421 ? 104.888 145.338 124.458 1.00 105.68 ? 283 GLU R CB  1 
ATOM   2030 C CG  . GLU A 1 421 ? 105.731 146.543 124.838 1.00 106.11 ? 283 GLU R CG  1 
ATOM   2031 C CD  . GLU A 1 421 ? 106.227 146.480 126.269 1.00 107.94 ? 283 GLU R CD  1 
ATOM   2032 O OE1 . GLU A 1 421 ? 105.462 146.025 127.145 1.00 107.67 ? 283 GLU R OE1 1 
ATOM   2033 O OE2 . GLU A 1 421 ? 107.383 146.881 126.518 1.00 106.67 ? 283 GLU R OE2 1 
ATOM   2034 N N   . PHE A 1 422 ? 106.380 142.520 125.174 1.00 82.58  ? 284 PHE R N   1 
ATOM   2035 C CA  . PHE A 1 422 ? 107.356 141.839 126.016 1.00 79.38  ? 284 PHE R CA  1 
ATOM   2036 C C   . PHE A 1 422 ? 108.525 141.314 125.194 1.00 82.76  ? 284 PHE R C   1 
ATOM   2037 O O   . PHE A 1 422 ? 109.677 141.370 125.638 1.00 81.89  ? 284 PHE R O   1 
ATOM   2038 C CB  . PHE A 1 422 ? 106.683 140.702 126.783 1.00 76.26  ? 284 PHE R CB  1 
ATOM   2039 C CG  . PHE A 1 422 ? 107.449 140.251 127.991 1.00 78.05  ? 284 PHE R CG  1 
ATOM   2040 C CD1 . PHE A 1 422 ? 107.924 141.170 128.909 1.00 82.24  ? 284 PHE R CD1 1 
ATOM   2041 C CD2 . PHE A 1 422 ? 107.696 138.907 128.209 1.00 83.02  ? 284 PHE R CD2 1 
ATOM   2042 C CE1 . PHE A 1 422 ? 108.630 140.758 130.022 1.00 83.16  ? 284 PHE R CE1 1 
ATOM   2043 C CE2 . PHE A 1 422 ? 108.401 138.489 129.319 1.00 82.59  ? 284 PHE R CE2 1 
ATOM   2044 C CZ  . PHE A 1 422 ? 108.869 139.416 130.227 1.00 82.36  ? 284 PHE R CZ  1 
ATOM   2045 N N   . GLU A 1 423 ? 108.252 140.803 123.992 1.00 94.65  ? 285 GLU R N   1 
ATOM   2046 C CA  . GLU A 1 423 ? 109.321 140.263 123.157 1.00 96.74  ? 285 GLU R CA  1 
ATOM   2047 C C   . GLU A 1 423 ? 110.338 141.339 122.792 1.00 99.46  ? 285 GLU R C   1 
ATOM   2048 O O   . GLU A 1 423 ? 111.551 141.133 122.925 1.00 99.02  ? 285 GLU R O   1 
ATOM   2049 C CB  . GLU A 1 423 ? 108.734 139.627 121.897 1.00 97.50  ? 285 GLU R CB  1 
ATOM   2050 C CG  . GLU A 1 423 ? 108.469 138.137 122.025 1.00 97.98  ? 285 GLU R CG  1 
ATOM   2051 C CD  . GLU A 1 423 ? 107.121 137.839 122.647 1.00 102.13 ? 285 GLU R CD  1 
ATOM   2052 O OE1 . GLU A 1 423 ? 106.298 138.771 122.759 1.00 101.83 ? 285 GLU R OE1 1 
ATOM   2053 O OE2 . GLU A 1 423 ? 106.886 136.673 123.029 1.00 101.25 ? 285 GLU R OE2 1 
ATOM   2054 N N   . ASN A 1 424 ? 109.865 142.498 122.328 1.00 103.58 ? 286 ASN R N   1 
ATOM   2055 C CA  . ASN A 1 424 ? 110.796 143.553 121.940 1.00 102.79 ? 286 ASN R CA  1 
ATOM   2056 C C   . ASN A 1 424 ? 111.501 144.138 123.157 1.00 97.80  ? 286 ASN R C   1 
ATOM   2057 O O   . ASN A 1 424 ? 112.686 144.488 123.084 1.00 97.13  ? 286 ASN R O   1 
ATOM   2058 C CB  . ASN A 1 424 ? 110.074 144.640 121.138 1.00 98.42  ? 286 ASN R CB  1 
ATOM   2059 C CG  . ASN A 1 424 ? 108.979 145.336 121.926 1.00 98.75  ? 286 ASN R CG  1 
ATOM   2060 O OD1 . ASN A 1 424 ? 109.216 145.884 123.002 1.00 96.73  ? 286 ASN R OD1 1 
ATOM   2061 N ND2 . ASN A 1 424 ? 107.770 145.329 121.379 1.00 99.37  ? 286 ASN R ND2 1 
ATOM   2062 N N   . THR A 1 425 ? 110.794 144.244 124.287 1.00 90.04  ? 287 THR R N   1 
ATOM   2063 C CA  . THR A 1 425 ? 111.445 144.713 125.506 1.00 94.00  ? 287 THR R CA  1 
ATOM   2064 C C   . THR A 1 425 ? 112.577 143.777 125.912 1.00 97.13  ? 287 THR R C   1 
ATOM   2065 O O   . THR A 1 425 ? 113.671 144.233 126.267 1.00 99.68  ? 287 THR R O   1 
ATOM   2066 C CB  . THR A 1 425 ? 110.422 144.845 126.633 1.00 93.57  ? 287 THR R CB  1 
ATOM   2067 O OG1 . THR A 1 425 ? 109.434 145.818 126.270 1.00 90.91  ? 287 THR R OG1 1 
ATOM   2068 C CG2 . THR A 1 425 ? 111.101 145.281 127.922 1.00 91.10  ? 287 THR R CG2 1 
ATOM   2069 N N   . VAL A 1 426 ? 112.343 142.464 125.839 1.00 75.94  ? 288 VAL R N   1 
ATOM   2070 C CA  . VAL A 1 426 ? 113.390 141.497 126.150 1.00 73.41  ? 288 VAL R CA  1 
ATOM   2071 C C   . VAL A 1 426 ? 114.535 141.546 125.147 1.00 78.82  ? 288 VAL R C   1 
ATOM   2072 O O   . VAL A 1 426 ? 115.699 141.435 125.548 1.00 87.15  ? 288 VAL R O   1 
ATOM   2073 C CB  . VAL A 1 426 ? 112.811 140.076 126.232 1.00 69.96  ? 288 VAL R CB  1 
ATOM   2074 C CG1 . VAL A 1 426 ? 113.923 139.051 126.343 1.00 70.36  ? 288 VAL R CG1 1 
ATOM   2075 C CG2 . VAL A 1 426 ? 111.886 139.964 127.427 1.00 77.68  ? 288 VAL R CG2 1 
ATOM   2076 N N   . HIS A 1 427 ? 114.245 141.714 123.856 1.00 72.57  ? 289 HIS R N   1 
ATOM   2077 C CA  . HIS A 1 427 ? 115.316 141.840 122.871 1.00 74.04  ? 289 HIS R CA  1 
ATOM   2078 C C   . HIS A 1 427 ? 116.212 143.035 123.181 1.00 74.85  ? 289 HIS R C   1 
ATOM   2079 O O   . HIS A 1 427 ? 117.446 142.912 123.208 1.00 73.82  ? 289 HIS R O   1 
ATOM   2080 C CB  . HIS A 1 427 ? 114.722 141.965 121.467 1.00 73.00  ? 289 HIS R CB  1 
ATOM   2081 C CG  . HIS A 1 427 ? 115.735 141.873 120.370 1.00 77.38  ? 289 HIS R CG  1 
ATOM   2082 N ND1 . HIS A 1 427 ? 116.503 142.947 119.974 1.00 80.50  ? 289 HIS R ND1 1 
ATOM   2083 C CD2 . HIS A 1 427 ? 116.096 140.839 119.573 1.00 78.11  ? 289 HIS R CD2 1 
ATOM   2084 C CE1 . HIS A 1 427 ? 117.301 142.575 118.989 1.00 80.82  ? 289 HIS R CE1 1 
ATOM   2085 N NE2 . HIS A 1 427 ? 117.075 141.301 118.727 1.00 80.06  ? 289 HIS R NE2 1 
ATOM   2086 N N   . LYS A 1 428 ? 115.599 144.196 123.439 1.00 69.68  ? 290 LYS R N   1 
ATOM   2087 C CA  . LYS A 1 428 ? 116.375 145.383 123.784 1.00 69.69  ? 290 LYS R CA  1 
ATOM   2088 C C   . LYS A 1 428 ? 117.184 145.160 125.053 1.00 70.95  ? 290 LYS R C   1 
ATOM   2089 O O   . LYS A 1 428 ? 118.374 145.503 125.112 1.00 79.79  ? 290 LYS R O   1 
ATOM   2090 C CB  . LYS A 1 428 ? 115.449 146.585 123.959 1.00 71.88  ? 290 LYS R CB  1 
ATOM   2091 C CG  . LYS A 1 428 ? 114.652 146.967 122.725 1.00 77.14  ? 290 LYS R CG  1 
ATOM   2092 C CD  . LYS A 1 428 ? 113.458 147.827 123.112 1.00 78.38  ? 290 LYS R CD  1 
ATOM   2093 C CE  . LYS A 1 428 ? 112.538 148.080 121.930 1.00 77.45  ? 290 LYS R CE  1 
ATOM   2094 N NZ  . LYS A 1 428 ? 112.452 149.528 121.598 1.00 72.71  ? 290 LYS R NZ  1 
ATOM   2095 N N   . TRP A 1 429 ? 116.552 144.589 126.081 1.00 47.10  ? 291 TRP R N   1 
ATOM   2096 C CA  . TRP A 1 429 ? 117.231 144.361 127.350 1.00 43.10  ? 291 TRP R CA  1 
ATOM   2097 C C   . TRP A 1 429 ? 118.449 143.470 127.159 1.00 47.36  ? 291 TRP R C   1 
ATOM   2098 O O   . TRP A 1 429 ? 119.539 143.779 127.649 1.00 57.39  ? 291 TRP R O   1 
ATOM   2099 C CB  . TRP A 1 429 ? 116.247 143.745 128.347 1.00 46.12  ? 291 TRP R CB  1 
ATOM   2100 C CG  . TRP A 1 429 ? 116.788 143.473 129.726 1.00 55.54  ? 291 TRP R CG  1 
ATOM   2101 C CD1 . TRP A 1 429 ? 118.030 143.774 130.202 1.00 59.86  ? 291 TRP R CD1 1 
ATOM   2102 C CD2 . TRP A 1 429 ? 116.090 142.843 130.807 1.00 60.01  ? 291 TRP R CD2 1 
ATOM   2103 N NE1 . TRP A 1 429 ? 118.151 143.369 131.508 1.00 54.90  ? 291 TRP R NE1 1 
ATOM   2104 C CE2 . TRP A 1 429 ? 116.972 142.795 131.904 1.00 56.65  ? 291 TRP R CE2 1 
ATOM   2105 C CE3 . TRP A 1 429 ? 114.804 142.315 130.952 1.00 62.05  ? 291 TRP R CE3 1 
ATOM   2106 C CZ2 . TRP A 1 429 ? 116.611 142.241 133.128 1.00 58.39  ? 291 TRP R CZ2 1 
ATOM   2107 C CZ3 . TRP A 1 429 ? 114.446 141.764 132.168 1.00 62.90  ? 291 TRP R CZ3 1 
ATOM   2108 C CH2 . TRP A 1 429 ? 115.346 141.731 133.241 1.00 61.60  ? 291 TRP R CH2 1 
ATOM   2109 N N   . ILE A 1 430 ? 118.290 142.368 126.423 1.00 46.35  ? 292 ILE R N   1 
ATOM   2110 C CA  . ILE A 1 430 ? 119.393 141.425 126.269 1.00 48.76  ? 292 ILE R CA  1 
ATOM   2111 C C   . ILE A 1 430 ? 120.524 142.044 125.462 1.00 59.52  ? 292 ILE R C   1 
ATOM   2112 O O   . ILE A 1 430 ? 121.701 141.874 125.796 1.00 68.39  ? 292 ILE R O   1 
ATOM   2113 C CB  . ILE A 1 430 ? 118.904 140.110 125.640 1.00 47.98  ? 292 ILE R CB  1 
ATOM   2114 C CG1 . ILE A 1 430 ? 117.856 139.448 126.531 1.00 54.82  ? 292 ILE R CG1 1 
ATOM   2115 C CG2 . ILE A 1 430 ? 120.070 139.165 125.459 1.00 52.11  ? 292 ILE R CG2 1 
ATOM   2116 C CD1 . ILE A 1 430 ? 117.548 138.021 126.150 1.00 56.20  ? 292 ILE R CD1 1 
ATOM   2117 N N   . SER A 1 431 ? 120.196 142.773 124.389 1.00 57.20  ? 293 SER R N   1 
ATOM   2118 C CA  . SER A 1 431 ? 121.253 143.387 123.587 1.00 55.90  ? 293 SER R CA  1 
ATOM   2119 C C   . SER A 1 431 ? 122.045 144.408 124.402 1.00 50.92  ? 293 SER R C   1 
ATOM   2120 O O   . SER A 1 431 ? 123.286 144.370 124.443 1.00 50.51  ? 293 SER R O   1 
ATOM   2121 C CB  . SER A 1 431 ? 120.653 144.038 122.341 1.00 58.90  ? 293 SER R CB  1 
ATOM   2122 O OG  . SER A 1 431 ? 120.112 143.062 121.469 1.00 63.54  ? 293 SER R OG  1 
ATOM   2123 N N   . ILE A 1 432 ? 121.337 145.317 125.079 1.00 44.33  ? 294 ILE R N   1 
ATOM   2124 C CA  . ILE A 1 432 ? 122.005 146.342 125.874 1.00 44.73  ? 294 ILE R CA  1 
ATOM   2125 C C   . ILE A 1 432 ? 122.835 145.704 126.981 1.00 55.26  ? 294 ILE R C   1 
ATOM   2126 O O   . ILE A 1 432 ? 123.970 146.121 127.253 1.00 62.09  ? 294 ILE R O   1 
ATOM   2127 C CB  . ILE A 1 432 ? 120.968 147.331 126.438 1.00 40.64  ? 294 ILE R CB  1 
ATOM   2128 C CG1 . ILE A 1 432 ? 120.404 148.204 125.317 1.00 45.49  ? 294 ILE R CG1 1 
ATOM   2129 C CG2 . ILE A 1 432 ? 121.578 148.188 127.532 1.00 46.81  ? 294 ILE R CG2 1 
ATOM   2130 C CD1 . ILE A 1 432 ? 119.233 149.056 125.742 1.00 47.34  ? 294 ILE R CD1 1 
ATOM   2131 N N   . THR A 1 433 ? 122.289 144.676 127.632 1.00 49.06  ? 295 THR R N   1 
ATOM   2132 C CA  . THR A 1 433 ? 122.986 144.069 128.754 1.00 36.71  ? 295 THR R CA  1 
ATOM   2133 C C   . THR A 1 433 ? 124.196 143.264 128.304 1.00 44.95  ? 295 THR R C   1 
ATOM   2134 O O   . THR A 1 433 ? 125.195 143.215 129.022 1.00 52.57  ? 295 THR R O   1 
ATOM   2135 C CB  . THR A 1 433 ? 122.022 143.200 129.550 1.00 41.90  ? 295 THR R CB  1 
ATOM   2136 O OG1 . THR A 1 433 ? 120.946 144.015 130.024 1.00 52.48  ? 295 THR R OG1 1 
ATOM   2137 C CG2 . THR A 1 433 ? 122.723 142.617 130.737 1.00 49.14  ? 295 THR R CG2 1 
ATOM   2138 N N   . GLU A 1 434 ? 124.145 142.635 127.129 1.00 51.05  ? 296 GLU R N   1 
ATOM   2139 C CA  . GLU A 1 434 ? 125.353 142.008 126.604 1.00 51.72  ? 296 GLU R CA  1 
ATOM   2140 C C   . GLU A 1 434 ? 126.422 143.047 126.300 1.00 58.13  ? 296 GLU R C   1 
ATOM   2141 O O   . GLU A 1 434 ? 127.610 142.827 126.583 1.00 61.65  ? 296 GLU R O   1 
ATOM   2142 C CB  . GLU A 1 434 ? 125.044 141.206 125.344 1.00 50.28  ? 296 GLU R CB  1 
ATOM   2143 C CG  . GLU A 1 434 ? 126.224 140.382 124.869 1.00 56.79  ? 296 GLU R CG  1 
ATOM   2144 C CD  . GLU A 1 434 ? 125.998 139.770 123.508 1.00 65.33  ? 296 GLU R CD  1 
ATOM   2145 O OE1 . GLU A 1 434 ? 125.427 140.460 122.637 1.00 60.85  ? 296 GLU R OE1 1 
ATOM   2146 O OE2 . GLU A 1 434 ? 126.392 138.602 123.306 1.00 64.72  ? 296 GLU R OE2 1 
ATOM   2147 N N   . ALA A 1 435 ? 126.018 144.181 125.721 1.00 59.66  ? 297 ALA R N   1 
ATOM   2148 C CA  . ALA A 1 435 ? 126.979 145.251 125.478 1.00 59.44  ? 297 ALA R CA  1 
ATOM   2149 C C   . ALA A 1 435 ? 127.644 145.693 126.774 1.00 52.64  ? 297 ALA R C   1 
ATOM   2150 O O   . ALA A 1 435 ? 128.866 145.868 126.827 1.00 51.31  ? 297 ALA R O   1 
ATOM   2151 C CB  . ALA A 1 435 ? 126.293 146.434 124.800 1.00 58.68  ? 297 ALA R CB  1 
ATOM   2152 N N   . LEU A 1 436 ? 126.855 145.868 127.835 1.00 35.39  ? 298 LEU R N   1 
ATOM   2153 C CA  . LEU A 1 436 ? 127.416 146.299 129.113 1.00 34.58  ? 298 LEU R CA  1 
ATOM   2154 C C   . LEU A 1 436 ? 128.179 145.190 129.830 1.00 42.39  ? 298 LEU R C   1 
ATOM   2155 O O   . LEU A 1 436 ? 129.056 145.491 130.645 1.00 53.45  ? 298 LEU R O   1 
ATOM   2156 C CB  . LEU A 1 436 ? 126.313 146.837 130.025 1.00 40.48  ? 298 LEU R CB  1 
ATOM   2157 C CG  . LEU A 1 436 ? 125.977 148.328 129.917 1.00 52.33  ? 298 LEU R CG  1 
ATOM   2158 C CD1 . LEU A 1 436 ? 127.176 149.178 130.309 1.00 54.64  ? 298 LEU R CD1 1 
ATOM   2159 C CD2 . LEU A 1 436 ? 125.490 148.697 128.528 1.00 46.09  ? 298 LEU R CD2 1 
ATOM   2160 N N   . ALA A 1 437 ? 127.864 143.925 129.558 1.00 41.65  ? 299 ALA R N   1 
ATOM   2161 C CA  . ALA A 1 437 ? 128.534 142.801 130.196 1.00 38.81  ? 299 ALA R CA  1 
ATOM   2162 C C   . ALA A 1 437 ? 129.830 142.416 129.505 1.00 41.68  ? 299 ALA R C   1 
ATOM   2163 O O   . ALA A 1 437 ? 130.625 141.672 130.088 1.00 40.23  ? 299 ALA R O   1 
ATOM   2164 C CB  . ALA A 1 437 ? 127.602 141.590 130.242 1.00 38.71  ? 299 ALA R CB  1 
ATOM   2165 N N   . PHE A 1 438 ? 130.058 142.892 128.282 1.00 59.77  ? 300 PHE R N   1 
ATOM   2166 C CA  . PHE A 1 438 ? 131.381 142.730 127.683 1.00 57.38  ? 300 PHE R CA  1 
ATOM   2167 C C   . PHE A 1 438 ? 132.469 143.507 128.420 1.00 50.62  ? 300 PHE R C   1 
ATOM   2168 O O   . PHE A 1 438 ? 133.629 143.454 127.999 1.00 48.63  ? 300 PHE R O   1 
ATOM   2169 C CB  . PHE A 1 438 ? 131.362 143.153 126.212 1.00 48.30  ? 300 PHE R CB  1 
ATOM   2170 C CG  . PHE A 1 438 ? 130.861 142.088 125.280 1.00 48.13  ? 300 PHE R CG  1 
ATOM   2171 C CD1 . PHE A 1 438 ? 130.716 140.782 125.712 1.00 53.75  ? 300 PHE R CD1 1 
ATOM   2172 C CD2 . PHE A 1 438 ? 130.547 142.391 123.967 1.00 41.66  ? 300 PHE R CD2 1 
ATOM   2173 C CE1 . PHE A 1 438 ? 130.257 139.802 124.855 1.00 52.23  ? 300 PHE R CE1 1 
ATOM   2174 C CE2 . PHE A 1 438 ? 130.090 141.415 123.106 1.00 44.86  ? 300 PHE R CE2 1 
ATOM   2175 C CZ  . PHE A 1 438 ? 129.945 140.119 123.551 1.00 45.50  ? 300 PHE R CZ  1 
ATOM   2176 N N   . PHE A 1 439 ? 132.131 144.217 129.499 1.00 46.19  ? 301 PHE R N   1 
ATOM   2177 C CA  . PHE A 1 439 ? 133.106 144.978 130.271 1.00 40.38  ? 301 PHE R CA  1 
ATOM   2178 C C   . PHE A 1 439 ? 134.018 144.098 131.114 1.00 47.93  ? 301 PHE R C   1 
ATOM   2179 O O   . PHE A 1 439 ? 134.955 144.622 131.724 1.00 60.99  ? 301 PHE R O   1 
ATOM   2180 C CB  . PHE A 1 439 ? 132.396 145.978 131.186 1.00 41.77  ? 301 PHE R CB  1 
ATOM   2181 C CG  . PHE A 1 439 ? 132.145 147.314 130.551 1.00 44.15  ? 301 PHE R CG  1 
ATOM   2182 C CD1 . PHE A 1 439 ? 131.209 147.454 129.543 1.00 48.61  ? 301 PHE R CD1 1 
ATOM   2183 C CD2 . PHE A 1 439 ? 132.841 148.433 130.969 1.00 48.84  ? 301 PHE R CD2 1 
ATOM   2184 C CE1 . PHE A 1 439 ? 130.975 148.684 128.961 1.00 46.67  ? 301 PHE R CE1 1 
ATOM   2185 C CE2 . PHE A 1 439 ? 132.610 149.665 130.390 1.00 47.48  ? 301 PHE R CE2 1 
ATOM   2186 C CZ  . PHE A 1 439 ? 131.676 149.789 129.385 1.00 43.87  ? 301 PHE R CZ  1 
ATOM   2187 N N   . HIS A 1 440 ? 133.765 142.788 131.177 1.00 44.03  ? 302 HIS R N   1 
ATOM   2188 C CA  . HIS A 1 440 ? 134.577 141.910 132.012 1.00 47.29  ? 302 HIS R CA  1 
ATOM   2189 C C   . HIS A 1 440 ? 136.035 141.869 131.571 1.00 49.25  ? 302 HIS R C   1 
ATOM   2190 O O   . HIS A 1 440 ? 136.900 141.492 132.368 1.00 55.05  ? 302 HIS R O   1 
ATOM   2191 C CB  . HIS A 1 440 ? 133.993 140.495 132.009 1.00 47.33  ? 302 HIS R CB  1 
ATOM   2192 C CG  . HIS A 1 440 ? 134.515 139.624 130.908 1.00 51.01  ? 302 HIS R CG  1 
ATOM   2193 N ND1 . HIS A 1 440 ? 133.873 139.495 129.695 1.00 57.38  ? 302 HIS R ND1 1 
ATOM   2194 C CD2 . HIS A 1 440 ? 135.611 138.832 130.839 1.00 52.49  ? 302 HIS R CD2 1 
ATOM   2195 C CE1 . HIS A 1 440 ? 134.555 138.667 128.925 1.00 53.32  ? 302 HIS R CE1 1 
ATOM   2196 N NE2 . HIS A 1 440 ? 135.614 138.251 129.595 1.00 51.36  ? 302 HIS R NE2 1 
ATOM   2197 N N   . CYS A 1 441 ? 136.327 142.246 130.326 1.00 51.30  ? 303 CYS R N   1 
ATOM   2198 C CA  . CYS A 1 441 ? 137.690 142.188 129.812 1.00 53.16  ? 303 CYS R CA  1 
ATOM   2199 C C   . CYS A 1 441 ? 138.602 143.246 130.414 1.00 56.71  ? 303 CYS R C   1 
ATOM   2200 O O   . CYS A 1 441 ? 139.821 143.155 130.239 1.00 62.11  ? 303 CYS R O   1 
ATOM   2201 C CB  . CYS A 1 441 ? 137.679 142.332 128.291 1.00 59.87  ? 303 CYS R CB  1 
ATOM   2202 S SG  . CYS A 1 441 ? 136.615 141.148 127.450 1.00 77.21  ? 303 CYS R SG  1 
ATOM   2203 N N   . CYS A 1 442 ? 138.054 144.238 131.112 1.00 53.69  ? 304 CYS R N   1 
ATOM   2204 C CA  . CYS A 1 442 ? 138.835 145.345 131.645 1.00 47.58  ? 304 CYS R CA  1 
ATOM   2205 C C   . CYS A 1 442 ? 138.969 145.303 133.161 1.00 49.95  ? 304 CYS R C   1 
ATOM   2206 O O   . CYS A 1 442 ? 139.163 146.352 133.780 1.00 62.51  ? 304 CYS R O   1 
ATOM   2207 C CB  . CYS A 1 442 ? 138.214 146.676 131.221 1.00 41.95  ? 304 CYS R CB  1 
ATOM   2208 S SG  . CYS A 1 442 ? 137.714 146.751 129.489 1.00 60.50  ? 304 CYS R SG  1 
ATOM   2209 N N   . LEU A 1 443 ? 138.873 144.123 133.776 1.00 48.01  ? 305 LEU R N   1 
ATOM   2210 C CA  . LEU A 1 443 ? 138.861 144.057 135.234 1.00 47.45  ? 305 LEU R CA  1 
ATOM   2211 C C   . LEU A 1 443 ? 140.266 143.926 135.813 1.00 50.58  ? 305 LEU R C   1 
ATOM   2212 O O   . LEU A 1 443 ? 140.627 144.658 136.740 1.00 53.39  ? 305 LEU R O   1 
ATOM   2213 C CB  . LEU A 1 443 ? 137.977 142.900 135.695 1.00 53.36  ? 305 LEU R CB  1 
ATOM   2214 C CG  . LEU A 1 443 ? 136.488 143.103 135.420 1.00 54.35  ? 305 LEU R CG  1 
ATOM   2215 C CD1 . LEU A 1 443 ? 135.682 141.950 135.979 1.00 53.53  ? 305 LEU R CD1 1 
ATOM   2216 C CD2 . LEU A 1 443 ? 136.013 144.425 136.000 1.00 53.41  ? 305 LEU R CD2 1 
ATOM   2217 N N   . ASN A 1 444 ? 141.067 142.998 135.289 1.00 66.50  ? 306 ASN R N   1 
ATOM   2218 C CA  . ASN A 1 444 ? 142.420 142.812 135.814 1.00 61.10  ? 306 ASN R CA  1 
ATOM   2219 C C   . ASN A 1 444 ? 143.272 144.072 135.717 1.00 64.01  ? 306 ASN R C   1 
ATOM   2220 O O   . ASN A 1 444 ? 143.933 144.418 136.712 1.00 68.32  ? 306 ASN R O   1 
ATOM   2221 C CB  . ASN A 1 444 ? 143.097 141.631 135.110 1.00 60.91  ? 306 ASN R CB  1 
ATOM   2222 C CG  . ASN A 1 444 ? 142.205 140.414 135.028 1.00 67.48  ? 306 ASN R CG  1 
ATOM   2223 O OD1 . ASN A 1 444 ? 141.916 139.773 136.036 1.00 70.31  ? 306 ASN R OD1 1 
ATOM   2224 N ND2 . ASN A 1 444 ? 141.762 140.087 133.820 1.00 64.63  ? 306 ASN R ND2 1 
ATOM   2225 N N   . PRO A 1 445 ? 143.328 144.787 134.585 1.00 53.14  ? 307 PRO R N   1 
ATOM   2226 C CA  . PRO A 1 445 ? 144.087 146.048 134.577 1.00 54.04  ? 307 PRO R CA  1 
ATOM   2227 C C   . PRO A 1 445 ? 143.560 147.077 135.561 1.00 56.95  ? 307 PRO R C   1 
ATOM   2228 O O   . PRO A 1 445 ? 144.355 147.812 136.161 1.00 57.41  ? 307 PRO R O   1 
ATOM   2229 C CB  . PRO A 1 445 ? 143.949 146.529 133.125 1.00 54.97  ? 307 PRO R CB  1 
ATOM   2230 C CG  . PRO A 1 445 ? 143.646 145.302 132.348 1.00 44.87  ? 307 PRO R CG  1 
ATOM   2231 C CD  . PRO A 1 445 ? 142.790 144.480 133.248 1.00 46.31  ? 307 PRO R CD  1 
ATOM   2232 N N   . ILE A 1 446 ? 142.243 147.142 135.763 1.00 48.84  ? 308 ILE R N   1 
ATOM   2233 C CA  . ILE A 1 446 ? 141.686 148.119 136.693 1.00 38.90  ? 308 ILE R CA  1 
ATOM   2234 C C   . ILE A 1 446 ? 142.085 147.781 138.125 1.00 51.29  ? 308 ILE R C   1 
ATOM   2235 O O   . ILE A 1 446 ? 142.423 148.669 138.915 1.00 63.05  ? 308 ILE R O   1 
ATOM   2236 C CB  . ILE A 1 446 ? 140.159 148.211 136.530 1.00 43.38  ? 308 ILE R CB  1 
ATOM   2237 C CG1 . ILE A 1 446 ? 139.811 149.111 135.342 1.00 50.79  ? 308 ILE R CG1 1 
ATOM   2238 C CG2 . ILE A 1 446 ? 139.510 148.741 137.795 1.00 52.42  ? 308 ILE R CG2 1 
ATOM   2239 C CD1 . ILE A 1 446 ? 138.336 149.135 135.000 1.00 53.89  ? 308 ILE R CD1 1 
ATOM   2240 N N   . LEU A 1 447 ? 142.062 146.494 138.483 1.00 51.21  ? 309 LEU R N   1 
ATOM   2241 C CA  . LEU A 1 447 ? 142.502 146.113 139.822 1.00 48.43  ? 309 LEU R CA  1 
ATOM   2242 C C   . LEU A 1 447 ? 144.000 146.313 140.009 1.00 52.10  ? 309 LEU R C   1 
ATOM   2243 O O   . LEU A 1 447 ? 144.436 146.677 141.107 1.00 60.39  ? 309 LEU R O   1 
ATOM   2244 C CB  . LEU A 1 447 ? 142.123 144.667 140.128 1.00 51.56  ? 309 LEU R CB  1 
ATOM   2245 C CG  . LEU A 1 447 ? 140.741 144.457 140.751 1.00 54.10  ? 309 LEU R CG  1 
ATOM   2246 C CD1 . LEU A 1 447 ? 139.613 144.711 139.761 1.00 57.91  ? 309 LEU R CD1 1 
ATOM   2247 C CD2 . LEU A 1 447 ? 140.647 143.068 141.343 1.00 53.48  ? 309 LEU R CD2 1 
ATOM   2248 N N   . TYR A 1 448 ? 144.802 146.076 138.969 1.00 54.07  ? 310 TYR R N   1 
ATOM   2249 C CA  . TYR A 1 448 ? 146.223 146.402 139.063 1.00 54.79  ? 310 TYR R CA  1 
ATOM   2250 C C   . TYR A 1 448 ? 146.434 147.892 139.290 1.00 64.04  ? 310 TYR R C   1 
ATOM   2251 O O   . TYR A 1 448 ? 147.292 148.290 140.087 1.00 70.31  ? 310 TYR R O   1 
ATOM   2252 C CB  . TYR A 1 448 ? 146.962 145.943 137.810 1.00 58.13  ? 310 TYR R CB  1 
ATOM   2253 C CG  . TYR A 1 448 ? 147.260 144.464 137.777 1.00 63.76  ? 310 TYR R CG  1 
ATOM   2254 C CD1 . TYR A 1 448 ? 147.219 143.701 138.934 1.00 67.03  ? 310 TYR R CD1 1 
ATOM   2255 C CD2 . TYR A 1 448 ? 147.594 143.833 136.590 1.00 67.73  ? 310 TYR R CD2 1 
ATOM   2256 C CE1 . TYR A 1 448 ? 147.501 142.351 138.907 1.00 68.89  ? 310 TYR R CE1 1 
ATOM   2257 C CE2 . TYR A 1 448 ? 147.873 142.485 136.552 1.00 70.74  ? 310 TYR R CE2 1 
ATOM   2258 C CZ  . TYR A 1 448 ? 147.824 141.748 137.712 1.00 70.02  ? 310 TYR R CZ  1 
ATOM   2259 O OH  . TYR A 1 448 ? 148.103 140.404 137.672 1.00 67.80  ? 310 TYR R OH  1 
ATOM   2260 N N   . ALA A 1 449 ? 145.669 148.733 138.594 1.00 60.10  ? 311 ALA R N   1 
ATOM   2261 C CA  . ALA A 1 449 ? 145.768 150.171 138.819 1.00 59.77  ? 311 ALA R CA  1 
ATOM   2262 C C   . ALA A 1 449 ? 145.348 150.542 140.237 1.00 55.60  ? 311 ALA R C   1 
ATOM   2263 O O   . ALA A 1 449 ? 146.001 151.366 140.887 1.00 55.57  ? 311 ALA R O   1 
ATOM   2264 C CB  . ALA A 1 449 ? 144.922 150.923 137.793 1.00 58.82  ? 311 ALA R CB  1 
ATOM   2265 N N   . PHE A 1 450 ? 144.261 149.945 140.730 1.00 57.45  ? 312 PHE R N   1 
ATOM   2266 C CA  . PHE A 1 450 ? 143.770 150.276 142.065 1.00 56.00  ? 312 PHE R CA  1 
ATOM   2267 C C   . PHE A 1 450 ? 144.761 149.863 143.146 1.00 66.64  ? 312 PHE R C   1 
ATOM   2268 O O   . PHE A 1 450 ? 145.007 150.619 144.093 1.00 73.83  ? 312 PHE R O   1 
ATOM   2269 C CB  . PHE A 1 450 ? 142.419 149.606 142.316 1.00 57.92  ? 312 PHE R CB  1 
ATOM   2270 C CG  . PHE A 1 450 ? 141.270 150.266 141.615 1.00 61.92  ? 312 PHE R CG  1 
ATOM   2271 C CD1 . PHE A 1 450 ? 141.433 151.481 140.974 1.00 67.67  ? 312 PHE R CD1 1 
ATOM   2272 C CD2 . PHE A 1 450 ? 140.019 149.672 141.610 1.00 62.19  ? 312 PHE R CD2 1 
ATOM   2273 C CE1 . PHE A 1 450 ? 140.371 152.088 140.330 1.00 68.95  ? 312 PHE R CE1 1 
ATOM   2274 C CE2 . PHE A 1 450 ? 138.953 150.273 140.970 1.00 64.03  ? 312 PHE R CE2 1 
ATOM   2275 C CZ  . PHE A 1 450 ? 139.129 151.483 140.329 1.00 67.40  ? 312 PHE R CZ  1 
ATOM   2276 N N   . LEU A 1 451 ? 145.337 148.671 143.026 1.00 70.07  ? 313 LEU R N   1 
ATOM   2277 C CA  . LEU A 1 451 ? 146.164 148.084 144.075 1.00 67.86  ? 313 LEU R CA  1 
ATOM   2278 C C   . LEU A 1 451 ? 147.622 147.962 143.643 1.00 68.62  ? 313 LEU R C   1 
ATOM   2279 O O   . LEU A 1 451 ? 148.284 146.958 143.908 1.00 73.72  ? 313 LEU R O   1 
ATOM   2280 C CB  . LEU A 1 451 ? 145.612 146.724 144.490 1.00 65.77  ? 313 LEU R CB  1 
ATOM   2281 C CG  . LEU A 1 451 ? 144.202 146.749 145.085 1.00 66.84  ? 313 LEU R CG  1 
ATOM   2282 C CD1 . LEU A 1 451 ? 143.701 145.340 145.353 1.00 65.61  ? 313 LEU R CD1 1 
ATOM   2283 C CD2 . LEU A 1 451 ? 144.165 147.586 146.354 1.00 66.82  ? 313 LEU R CD2 1 
ATOM   2284 N N   . GLY A 1 452 ? 148.135 148.987 142.969 1.00 72.12  ? 314 GLY R N   1 
ATOM   2285 C CA  . GLY A 1 452 ? 149.513 148.978 142.520 1.00 75.20  ? 314 GLY R CA  1 
ATOM   2286 C C   . GLY A 1 452 ? 150.277 150.227 142.904 1.00 74.84  ? 314 GLY R C   1 
ATOM   2287 O O   . GLY A 1 452 ? 151.133 150.696 142.147 1.00 77.11  ? 314 GLY R O   1 
ATOM   2288 N N   . ALA A 1 453 ? 149.979 150.776 144.076 1.00 82.82  ? 315 ALA R N   1 
ATOM   2289 C CA  . ALA A 1 453 ? 150.650 151.983 144.544 1.00 86.61  ? 315 ALA R CA  1 
ATOM   2290 C C   . ALA A 1 453 ? 151.755 151.644 145.538 1.00 87.92  ? 315 ALA R C   1 
ATOM   2291 O O   . ALA A 1 453 ? 151.613 150.732 146.352 1.00 91.04  ? 315 ALA R O   1 
ATOM   2292 C CB  . ALA A 1 453 ? 149.646 152.938 145.172 1.00 86.37  ? 315 ALA R CB  1 
ATOM   2293 N N   . GLN B 2 41  ? 140.378 153.831 165.705 1.00 114.98 ? 3   GLN N N   1 
ATOM   2294 C CA  . GLN B 2 41  ? 140.899 152.672 166.419 1.00 115.92 ? 3   GLN N CA  1 
ATOM   2295 C C   . GLN B 2 41  ? 139.953 152.248 167.539 1.00 116.61 ? 3   GLN N C   1 
ATOM   2296 O O   . GLN B 2 41  ? 138.734 152.339 167.401 1.00 117.36 ? 3   GLN N O   1 
ATOM   2297 C CB  . GLN B 2 41  ? 142.288 152.970 166.986 1.00 113.51 ? 3   GLN N CB  1 
ATOM   2298 N N   . VAL B 2 42  ? 140.526 151.784 168.650 1.00 108.82 ? 4   VAL N N   1 
ATOM   2299 C CA  . VAL B 2 42  ? 139.760 151.322 169.798 1.00 107.26 ? 4   VAL N CA  1 
ATOM   2300 C C   . VAL B 2 42  ? 140.317 151.981 171.052 1.00 109.41 ? 4   VAL N C   1 
ATOM   2301 O O   . VAL B 2 42  ? 141.441 152.487 171.071 1.00 111.73 ? 4   VAL N O   1 
ATOM   2302 C CB  . VAL B 2 42  ? 139.789 149.787 169.942 1.00 107.76 ? 4   VAL N CB  1 
ATOM   2303 C CG1 . VAL B 2 42  ? 139.182 149.133 168.717 1.00 107.19 ? 4   VAL N CG1 1 
ATOM   2304 C CG2 . VAL B 2 42  ? 141.212 149.302 170.162 1.00 108.08 ? 4   VAL N CG2 1 
ATOM   2305 N N   . GLN B 2 43  ? 139.511 151.967 172.109 1.00 104.20 ? 5   GLN N N   1 
ATOM   2306 C CA  . GLN B 2 43  ? 139.869 152.587 173.378 1.00 103.77 ? 5   GLN N CA  1 
ATOM   2307 C C   . GLN B 2 43  ? 139.781 151.557 174.494 1.00 104.02 ? 5   GLN N C   1 
ATOM   2308 O O   . GLN B 2 43  ? 138.787 150.832 174.599 1.00 102.55 ? 5   GLN N O   1 
ATOM   2309 C CB  . GLN B 2 43  ? 138.956 153.778 173.682 1.00 103.54 ? 5   GLN N CB  1 
ATOM   2310 N N   . LEU B 2 44  ? 140.823 151.496 175.321 1.00 112.80 ? 6   LEU N N   1 
ATOM   2311 C CA  . LEU B 2 44  ? 140.854 150.637 176.495 1.00 113.10 ? 6   LEU N CA  1 
ATOM   2312 C C   . LEU B 2 44  ? 141.252 151.462 177.709 1.00 111.63 ? 6   LEU N C   1 
ATOM   2313 O O   . LEU B 2 44  ? 142.158 152.298 177.632 1.00 112.51 ? 6   LEU N O   1 
ATOM   2314 C CB  . LEU B 2 44  ? 141.834 149.466 176.326 1.00 111.92 ? 6   LEU N CB  1 
ATOM   2315 C CG  . LEU B 2 44  ? 141.390 148.242 175.521 1.00 110.14 ? 6   LEU N CG  1 
ATOM   2316 C CD1 . LEU B 2 44  ? 141.414 148.520 174.027 1.00 112.32 ? 6   LEU N CD1 1 
ATOM   2317 C CD2 . LEU B 2 44  ? 142.256 147.040 175.861 1.00 108.02 ? 6   LEU N CD2 1 
ATOM   2318 N N   . GLN B 2 45  ? 140.574 151.224 178.827 1.00 122.11 ? 7   GLN N N   1 
ATOM   2319 C CA  . GLN B 2 45  ? 140.875 151.890 180.084 1.00 123.35 ? 7   GLN N CA  1 
ATOM   2320 C C   . GLN B 2 45  ? 140.957 150.852 181.193 1.00 125.22 ? 7   GLN N C   1 
ATOM   2321 O O   . GLN B 2 45  ? 140.607 149.683 181.011 1.00 124.59 ? 7   GLN N O   1 
ATOM   2322 C CB  . GLN B 2 45  ? 139.824 152.956 180.426 1.00 123.86 ? 7   GLN N CB  1 
ATOM   2323 C CG  . GLN B 2 45  ? 139.769 154.114 179.443 1.00 125.22 ? 7   GLN N CG  1 
ATOM   2324 C CD  . GLN B 2 45  ? 138.657 155.094 179.760 1.00 126.83 ? 7   GLN N CD  1 
ATOM   2325 O OE1 . GLN B 2 45  ? 137.870 154.881 180.683 1.00 126.81 ? 7   GLN N OE1 1 
ATOM   2326 N NE2 . GLN B 2 45  ? 138.586 156.176 178.994 1.00 126.29 ? 7   GLN N NE2 1 
ATOM   2327 N N   . GLU B 2 46  ? 141.436 151.290 182.354 1.00 131.21 ? 8   GLU N N   1 
ATOM   2328 C CA  . GLU B 2 46  ? 141.565 150.423 183.514 1.00 129.49 ? 8   GLU N CA  1 
ATOM   2329 C C   . GLU B 2 46  ? 141.045 151.152 184.744 1.00 131.13 ? 8   GLU N C   1 
ATOM   2330 O O   . GLU B 2 46  ? 141.067 152.383 184.810 1.00 133.62 ? 8   GLU N O   1 
ATOM   2331 C CB  . GLU B 2 46  ? 143.017 149.989 183.741 1.00 130.07 ? 8   GLU N CB  1 
ATOM   2332 C CG  . GLU B 2 46  ? 143.733 149.496 182.500 1.00 131.19 ? 8   GLU N CG  1 
ATOM   2333 C CD  . GLU B 2 46  ? 145.036 148.799 182.827 1.00 132.46 ? 8   GLU N CD  1 
ATOM   2334 O OE1 . GLU B 2 46  ? 145.217 148.396 183.995 1.00 133.68 ? 8   GLU N OE1 1 
ATOM   2335 O OE2 . GLU B 2 46  ? 145.883 148.659 181.921 1.00 132.13 ? 8   GLU N OE2 1 
ATOM   2336 N N   . SER B 2 47  ? 140.580 150.377 185.720 1.00 131.70 ? 9   SER N N   1 
ATOM   2337 C CA  . SER B 2 47  ? 140.035 150.938 186.948 1.00 133.02 ? 9   SER N CA  1 
ATOM   2338 C C   . SER B 2 47  ? 140.078 149.870 188.031 1.00 133.99 ? 9   SER N C   1 
ATOM   2339 O O   . SER B 2 47  ? 140.493 148.733 187.795 1.00 133.48 ? 9   SER N O   1 
ATOM   2340 C CB  . SER B 2 47  ? 138.607 151.453 186.741 1.00 133.06 ? 9   SER N CB  1 
ATOM   2341 O OG  . SER B 2 47  ? 137.672 150.388 186.760 1.00 131.54 ? 9   SER N OG  1 
ATOM   2342 N N   . GLY B 2 48  ? 139.642 150.255 189.228 1.00 143.65 ? 10  GLY N N   1 
ATOM   2343 C CA  . GLY B 2 48  ? 139.574 149.358 190.364 1.00 142.79 ? 10  GLY N CA  1 
ATOM   2344 C C   . GLY B 2 48  ? 140.655 149.563 191.402 1.00 142.21 ? 10  GLY N C   1 
ATOM   2345 O O   . GLY B 2 48  ? 140.622 148.893 192.442 1.00 141.80 ? 10  GLY N O   1 
ATOM   2346 N N   . GLY B 2 49  ? 141.608 150.459 191.160 1.00 152.13 ? 11  GLY N N   1 
ATOM   2347 C CA  . GLY B 2 49  ? 142.679 150.699 192.102 1.00 152.23 ? 11  GLY N CA  1 
ATOM   2348 C C   . GLY B 2 49  ? 142.285 151.651 193.214 1.00 153.78 ? 11  GLY N C   1 
ATOM   2349 O O   . GLY B 2 49  ? 141.181 152.195 193.261 1.00 154.57 ? 11  GLY N O   1 
ATOM   2350 N N   . GLY B 2 50  ? 143.222 151.850 194.132 1.00 166.44 ? 12  GLY N N   1 
ATOM   2351 C CA  . GLY B 2 50  ? 143.040 152.734 195.259 1.00 166.83 ? 12  GLY N CA  1 
ATOM   2352 C C   . GLY B 2 50  ? 143.655 152.134 196.504 1.00 166.35 ? 12  GLY N C   1 
ATOM   2353 O O   . GLY B 2 50  ? 144.373 151.138 196.441 1.00 165.39 ? 12  GLY N O   1 
ATOM   2354 N N   . LEU B 2 51  ? 143.362 152.755 197.644 1.00 182.71 ? 13  LEU N N   1 
ATOM   2355 C CA  . LEU B 2 51  ? 143.856 152.290 198.936 1.00 183.14 ? 13  LEU N CA  1 
ATOM   2356 C C   . LEU B 2 51  ? 142.860 151.284 199.500 1.00 183.57 ? 13  LEU N C   1 
ATOM   2357 O O   . LEU B 2 51  ? 141.719 151.638 199.814 1.00 183.97 ? 13  LEU N O   1 
ATOM   2358 C CB  . LEU B 2 51  ? 144.060 153.462 199.892 1.00 182.22 ? 13  LEU N CB  1 
ATOM   2359 N N   . VAL B 2 52  ? 143.290 150.032 199.629 1.00 187.51 ? 14  VAL N N   1 
ATOM   2360 C CA  . VAL B 2 52  ? 142.431 148.943 200.074 1.00 187.85 ? 14  VAL N CA  1 
ATOM   2361 C C   . VAL B 2 52  ? 143.145 148.168 201.173 1.00 187.65 ? 14  VAL N C   1 
ATOM   2362 O O   . VAL B 2 52  ? 144.359 147.942 201.101 1.00 187.11 ? 14  VAL N O   1 
ATOM   2363 C CB  . VAL B 2 52  ? 142.038 148.018 198.899 1.00 186.84 ? 14  VAL N CB  1 
ATOM   2364 C CG1 . VAL B 2 52  ? 143.274 147.422 198.237 1.00 186.36 ? 14  VAL N CG1 1 
ATOM   2365 C CG2 . VAL B 2 52  ? 141.092 146.925 199.366 1.00 185.89 ? 14  VAL N CG2 1 
ATOM   2366 N N   . GLN B 2 53  ? 142.395 147.783 202.202 1.00 187.85 ? 15  GLN N N   1 
ATOM   2367 C CA  . GLN B 2 53  ? 142.956 147.000 203.290 1.00 187.24 ? 15  GLN N CA  1 
ATOM   2368 C C   . GLN B 2 53  ? 143.274 145.582 202.821 1.00 187.93 ? 15  GLN N C   1 
ATOM   2369 O O   . GLN B 2 53  ? 142.687 145.065 201.866 1.00 188.11 ? 15  GLN N O   1 
ATOM   2370 C CB  . GLN B 2 53  ? 141.991 146.959 204.475 1.00 186.41 ? 15  GLN N CB  1 
ATOM   2371 N N   . ALA B 2 54  ? 144.223 144.954 203.510 1.00 187.58 ? 16  ALA N N   1 
ATOM   2372 C CA  . ALA B 2 54  ? 144.656 143.613 203.144 1.00 186.95 ? 16  ALA N CA  1 
ATOM   2373 C C   . ALA B 2 54  ? 143.528 142.606 203.336 1.00 188.04 ? 16  ALA N C   1 
ATOM   2374 O O   . ALA B 2 54  ? 142.715 142.726 204.257 1.00 187.64 ? 16  ALA N O   1 
ATOM   2375 C CB  . ALA B 2 54  ? 145.873 143.203 203.972 1.00 185.32 ? 16  ALA N CB  1 
ATOM   2376 N N   . GLY B 2 55  ? 143.484 141.609 202.456 1.00 181.39 ? 17  GLY N N   1 
ATOM   2377 C CA  . GLY B 2 55  ? 142.475 140.573 202.543 1.00 179.44 ? 17  GLY N CA  1 
ATOM   2378 C C   . GLY B 2 55  ? 141.104 140.961 202.042 1.00 178.89 ? 17  GLY N C   1 
ATOM   2379 O O   . GLY B 2 55  ? 140.124 140.292 202.381 1.00 178.10 ? 17  GLY N O   1 
ATOM   2380 N N   . GLU B 2 56  ? 141.000 142.021 201.245 1.00 170.86 ? 18  GLU N N   1 
ATOM   2381 C CA  . GLU B 2 56  ? 139.720 142.448 200.705 1.00 170.19 ? 18  GLU N CA  1 
ATOM   2382 C C   . GLU B 2 56  ? 139.539 141.906 199.288 1.00 168.93 ? 18  GLU N C   1 
ATOM   2383 O O   . GLU B 2 56  ? 140.426 141.263 198.720 1.00 167.62 ? 18  GLU N O   1 
ATOM   2384 C CB  . GLU B 2 56  ? 139.611 143.971 200.735 1.00 170.61 ? 18  GLU N CB  1 
ATOM   2385 C CG  . GLU B 2 56  ? 139.141 144.535 202.067 1.00 170.50 ? 18  GLU N CG  1 
ATOM   2386 C CD  . GLU B 2 56  ? 137.684 144.227 202.352 1.00 169.33 ? 18  GLU N CD  1 
ATOM   2387 O OE1 . GLU B 2 56  ? 136.900 144.108 201.387 1.00 169.31 ? 18  GLU N OE1 1 
ATOM   2388 O OE2 . GLU B 2 56  ? 137.323 144.102 203.541 1.00 168.32 ? 18  GLU N OE2 1 
ATOM   2389 N N   . SER B 2 57  ? 138.372 142.171 198.706 1.00 163.35 ? 19  SER N N   1 
ATOM   2390 C CA  . SER B 2 57  ? 138.013 141.667 197.387 1.00 163.51 ? 19  SER N CA  1 
ATOM   2391 C C   . SER B 2 57  ? 137.641 142.827 196.476 1.00 163.07 ? 19  SER N C   1 
ATOM   2392 O O   . SER B 2 57  ? 136.884 143.718 196.876 1.00 163.53 ? 19  SER N O   1 
ATOM   2393 C CB  . SER B 2 57  ? 136.852 140.672 197.476 1.00 162.69 ? 19  SER N CB  1 
ATOM   2394 O OG  . SER B 2 57  ? 137.237 139.500 198.173 1.00 162.73 ? 19  SER N OG  1 
ATOM   2395 N N   . LEU B 2 58  ? 138.174 142.810 195.256 1.00 147.24 ? 20  LEU N N   1 
ATOM   2396 C CA  . LEU B 2 58  ? 137.861 143.809 194.246 1.00 145.63 ? 20  LEU N CA  1 
ATOM   2397 C C   . LEU B 2 58  ? 137.980 143.172 192.869 1.00 144.92 ? 20  LEU N C   1 
ATOM   2398 O O   . LEU B 2 58  ? 138.545 142.087 192.711 1.00 144.10 ? 20  LEU N O   1 
ATOM   2399 C CB  . LEU B 2 58  ? 138.777 145.036 194.350 1.00 145.60 ? 20  LEU N CB  1 
ATOM   2400 C CG  . LEU B 2 58  ? 138.219 146.232 195.123 1.00 146.03 ? 20  LEU N CG  1 
ATOM   2401 C CD1 . LEU B 2 58  ? 139.213 147.383 195.127 1.00 146.57 ? 20  LEU N CD1 1 
ATOM   2402 C CD2 . LEU B 2 58  ? 136.885 146.673 194.539 1.00 146.16 ? 20  LEU N CD2 1 
ATOM   2403 N N   . ARG B 2 59  ? 137.429 143.856 191.869 1.00 136.94 ? 21  ARG N N   1 
ATOM   2404 C CA  . ARG B 2 59  ? 137.414 143.358 190.497 1.00 136.48 ? 21  ARG N CA  1 
ATOM   2405 C C   . ARG B 2 59  ? 137.862 144.474 189.563 1.00 136.46 ? 21  ARG N C   1 
ATOM   2406 O O   . ARG B 2 59  ? 137.147 145.466 189.387 1.00 136.37 ? 21  ARG N O   1 
ATOM   2407 C CB  . ARG B 2 59  ? 136.025 142.847 190.113 1.00 136.29 ? 21  ARG N CB  1 
ATOM   2408 C CG  . ARG B 2 59  ? 135.619 141.572 190.834 1.00 135.50 ? 21  ARG N CG  1 
ATOM   2409 C CD  . ARG B 2 59  ? 134.159 141.232 190.591 1.00 134.64 ? 21  ARG N CD  1 
ATOM   2410 N NE  . ARG B 2 59  ? 133.907 140.842 189.210 1.00 136.95 ? 21  ARG N NE  1 
ATOM   2411 C CZ  . ARG B 2 59  ? 132.703 140.614 188.704 1.00 137.65 ? 21  ARG N CZ  1 
ATOM   2412 N NH1 . ARG B 2 59  ? 131.611 140.730 189.442 1.00 136.16 ? 21  ARG N NH1 1 
ATOM   2413 N NH2 . ARG B 2 59  ? 132.591 140.261 187.427 1.00 137.41 ? 21  ARG N NH2 1 
ATOM   2414 N N   . LEU B 2 60  ? 139.041 144.312 188.970 1.00 132.35 ? 22  LEU N N   1 
ATOM   2415 C CA  . LEU B 2 60  ? 139.520 145.264 187.981 1.00 130.18 ? 22  LEU N CA  1 
ATOM   2416 C C   . LEU B 2 60  ? 138.710 145.135 186.695 1.00 130.51 ? 22  LEU N C   1 
ATOM   2417 O O   . LEU B 2 60  ? 138.161 144.075 186.385 1.00 131.95 ? 22  LEU N O   1 
ATOM   2418 C CB  . LEU B 2 60  ? 141.002 145.032 187.693 1.00 130.86 ? 22  LEU N CB  1 
ATOM   2419 C CG  . LEU B 2 60  ? 141.981 145.198 188.858 1.00 132.64 ? 22  LEU N CG  1 
ATOM   2420 C CD1 . LEU B 2 60  ? 143.409 145.319 188.345 1.00 131.89 ? 22  LEU N CD1 1 
ATOM   2421 C CD2 . LEU B 2 60  ? 141.615 146.394 189.721 1.00 132.03 ? 22  LEU N CD2 1 
ATOM   2422 N N   . SER B 2 61  ? 138.637 146.228 185.942 1.00 131.24 ? 23  SER N N   1 
ATOM   2423 C CA  . SER B 2 61  ? 137.855 146.268 184.715 1.00 131.56 ? 23  SER N CA  1 
ATOM   2424 C C   . SER B 2 61  ? 138.690 146.845 183.582 1.00 130.94 ? 23  SER N C   1 
ATOM   2425 O O   . SER B 2 61  ? 139.555 147.697 183.807 1.00 132.23 ? 23  SER N O   1 
ATOM   2426 C CB  . SER B 2 61  ? 136.576 147.097 184.897 1.00 132.48 ? 23  SER N CB  1 
ATOM   2427 O OG  . SER B 2 61  ? 136.878 148.450 185.189 1.00 132.66 ? 23  SER N OG  1 
ATOM   2428 N N   . CYS B 2 62  ? 138.426 146.372 182.364 1.00 116.68 ? 24  CYS N N   1 
ATOM   2429 C CA  . CYS B 2 62  ? 139.126 146.860 181.176 1.00 115.85 ? 24  CYS N CA  1 
ATOM   2430 C C   . CYS B 2 62  ? 138.185 146.671 179.989 1.00 115.77 ? 24  CYS N C   1 
ATOM   2431 O O   . CYS B 2 62  ? 138.084 145.567 179.446 1.00 118.14 ? 24  CYS N O   1 
ATOM   2432 C CB  . CYS B 2 62  ? 140.443 146.125 180.978 1.00 120.98 ? 24  CYS N CB  1 
ATOM   2433 S SG  . CYS B 2 62  ? 141.387 146.616 179.519 1.00 124.42 ? 24  CYS N SG  1 
ATOM   2434 N N   . ALA B 2 63  ? 137.511 147.746 179.593 1.00 114.04 ? 25  ALA N N   1 
ATOM   2435 C CA  . ALA B 2 63  ? 136.486 147.696 178.559 1.00 116.09 ? 25  ALA N CA  1 
ATOM   2436 C C   . ALA B 2 63  ? 137.026 148.270 177.257 1.00 114.59 ? 25  ALA N C   1 
ATOM   2437 O O   . ALA B 2 63  ? 137.608 149.360 177.247 1.00 114.39 ? 25  ALA N O   1 
ATOM   2438 C CB  . ALA B 2 63  ? 135.238 148.465 178.993 1.00 115.95 ? 25  ALA N CB  1 
ATOM   2439 N N   . ALA B 2 64  ? 136.827 147.539 176.166 1.00 104.55 ? 26  ALA N N   1 
ATOM   2440 C CA  . ALA B 2 64  ? 137.251 147.962 174.840 1.00 103.60 ? 26  ALA N CA  1 
ATOM   2441 C C   . ALA B 2 64  ? 136.028 148.322 174.010 1.00 107.97 ? 26  ALA N C   1 
ATOM   2442 O O   . ALA B 2 64  ? 135.065 147.549 173.950 1.00 109.92 ? 26  ALA N O   1 
ATOM   2443 C CB  . ALA B 2 64  ? 138.058 146.865 174.144 1.00 106.23 ? 26  ALA N CB  1 
ATOM   2444 N N   . SER B 2 65  ? 136.067 149.491 173.376 1.00 115.49 ? 27  SER N N   1 
ATOM   2445 C CA  . SER B 2 65  ? 134.977 149.950 172.529 1.00 114.18 ? 27  SER N CA  1 
ATOM   2446 C C   . SER B 2 65  ? 135.551 150.689 171.329 1.00 114.40 ? 27  SER N C   1 
ATOM   2447 O O   . SER B 2 65  ? 136.672 151.203 171.368 1.00 114.37 ? 27  SER N O   1 
ATOM   2448 C CB  . SER B 2 65  ? 134.005 150.856 173.297 1.00 111.92 ? 27  SER N CB  1 
ATOM   2449 N N   . GLY B 2 66  ? 134.765 150.736 170.257 1.00 111.83 ? 28  GLY N N   1 
ATOM   2450 C CA  . GLY B 2 66  ? 135.187 151.407 169.044 1.00 111.83 ? 28  GLY N CA  1 
ATOM   2451 C C   . GLY B 2 66  ? 135.136 150.511 167.824 1.00 112.66 ? 28  GLY N C   1 
ATOM   2452 O O   . GLY B 2 66  ? 134.248 149.662 167.707 1.00 112.10 ? 28  GLY N O   1 
ATOM   2453 N N   . THR B 2 67  ? 136.088 150.690 166.907 1.00 112.31 ? 29  THR N N   1 
ATOM   2454 C CA  . THR B 2 67  ? 136.160 149.881 165.690 1.00 111.56 ? 29  THR N CA  1 
ATOM   2455 C C   . THR B 2 67  ? 136.726 148.512 166.054 1.00 108.06 ? 29  THR N C   1 
ATOM   2456 O O   . THR B 2 67  ? 137.901 148.205 165.843 1.00 104.56 ? 29  THR N O   1 
ATOM   2457 C CB  . THR B 2 67  ? 137.007 150.570 164.628 1.00 110.34 ? 29  THR N CB  1 
ATOM   2458 O OG1 . THR B 2 67  ? 138.343 150.742 165.118 1.00 111.28 ? 29  THR N OG1 1 
ATOM   2459 C CG2 . THR B 2 67  ? 136.421 151.928 164.276 1.00 108.67 ? 29  THR N CG2 1 
ATOM   2460 N N   . ILE B 2 68  ? 135.859 147.673 166.612 1.00 101.02 ? 30  ILE N N   1 
ATOM   2461 C CA  . ILE B 2 68  ? 136.219 146.326 167.035 1.00 100.60 ? 30  ILE N CA  1 
ATOM   2462 C C   . ILE B 2 68  ? 135.586 145.344 166.063 1.00 99.71  ? 30  ILE N C   1 
ATOM   2463 O O   . ILE B 2 68  ? 134.357 145.291 165.933 1.00 100.82 ? 30  ILE N O   1 
ATOM   2464 C CB  . ILE B 2 68  ? 135.762 146.038 168.472 1.00 101.96 ? 30  ILE N CB  1 
ATOM   2465 C CG1 . ILE B 2 68  ? 136.581 146.853 169.470 1.00 102.47 ? 30  ILE N CG1 1 
ATOM   2466 C CG2 . ILE B 2 68  ? 135.881 144.555 168.779 1.00 99.91  ? 30  ILE N CG2 1 
ATOM   2467 C CD1 . ILE B 2 68  ? 136.096 146.733 170.892 1.00 102.30 ? 30  ILE N CD1 1 
ATOM   2468 N N   . PHE B 2 69  ? 136.423 144.568 165.377 1.00 87.01  ? 31  PHE N N   1 
ATOM   2469 C CA  . PHE B 2 69  ? 135.920 143.462 164.575 1.00 86.55  ? 31  PHE N CA  1 
ATOM   2470 C C   . PHE B 2 69  ? 135.939 142.154 165.353 1.00 90.28  ? 31  PHE N C   1 
ATOM   2471 O O   . PHE B 2 69  ? 135.051 141.314 165.172 1.00 93.49  ? 31  PHE N O   1 
ATOM   2472 C CB  . PHE B 2 69  ? 136.735 143.325 163.287 1.00 87.70  ? 31  PHE N CB  1 
ATOM   2473 C CG  . PHE B 2 69  ? 136.555 142.008 162.593 1.00 89.11  ? 31  PHE N CG  1 
ATOM   2474 C CD1 . PHE B 2 69  ? 135.366 141.704 161.955 1.00 85.63  ? 31  PHE N CD1 1 
ATOM   2475 C CD2 . PHE B 2 69  ? 137.575 141.073 162.578 1.00 89.67  ? 31  PHE N CD2 1 
ATOM   2476 C CE1 . PHE B 2 69  ? 135.197 140.493 161.317 1.00 86.49  ? 31  PHE N CE1 1 
ATOM   2477 C CE2 . PHE B 2 69  ? 137.412 139.861 161.941 1.00 88.36  ? 31  PHE N CE2 1 
ATOM   2478 C CZ  . PHE B 2 69  ? 136.222 139.571 161.311 1.00 88.48  ? 31  PHE N CZ  1 
ATOM   2479 N N   . ARG B 2 70  ? 136.928 141.977 166.229 1.00 89.06  ? 32  ARG N N   1 
ATOM   2480 C CA  . ARG B 2 70  ? 137.027 140.794 167.072 1.00 88.15  ? 32  ARG N CA  1 
ATOM   2481 C C   . ARG B 2 70  ? 138.106 141.022 168.117 1.00 83.63  ? 32  ARG N C   1 
ATOM   2482 O O   . ARG B 2 70  ? 139.130 141.645 167.829 1.00 84.96  ? 32  ARG N O   1 
ATOM   2483 C CB  . ARG B 2 70  ? 137.352 139.544 166.245 1.00 89.70  ? 32  ARG N CB  1 
ATOM   2484 C CG  . ARG B 2 70  ? 136.863 138.252 166.870 1.00 90.22  ? 32  ARG N CG  1 
ATOM   2485 C CD  . ARG B 2 70  ? 136.878 137.114 165.868 1.00 87.81  ? 32  ARG N CD  1 
ATOM   2486 N NE  . ARG B 2 70  ? 136.297 135.900 166.425 1.00 87.86  ? 32  ARG N NE  1 
ATOM   2487 C CZ  . ARG B 2 70  ? 134.995 135.651 166.476 1.00 92.13  ? 32  ARG N CZ  1 
ATOM   2488 N NH1 . ARG B 2 70  ? 134.108 136.514 166.009 1.00 91.84  ? 32  ARG N NH1 1 
ATOM   2489 N NH2 . ARG B 2 70  ? 134.573 134.507 167.008 1.00 92.33  ? 32  ARG N NH2 1 
ATOM   2490 N N   . LEU B 2 71  ? 137.868 140.519 169.325 1.00 85.04  ? 33  LEU N N   1 
ATOM   2491 C CA  . LEU B 2 71  ? 138.864 140.494 170.388 1.00 89.41  ? 33  LEU N CA  1 
ATOM   2492 C C   . LEU B 2 71  ? 139.306 139.054 170.604 1.00 87.77  ? 33  LEU N C   1 
ATOM   2493 O O   . LEU B 2 71  ? 138.467 138.169 170.799 1.00 91.08  ? 33  LEU N O   1 
ATOM   2494 C CB  . LEU B 2 71  ? 138.307 141.079 171.687 1.00 92.27  ? 33  LEU N CB  1 
ATOM   2495 C CG  . LEU B 2 71  ? 138.349 142.598 171.852 1.00 92.84  ? 33  LEU N CG  1 
ATOM   2496 C CD1 . LEU B 2 71  ? 137.501 143.025 173.036 1.00 90.07  ? 33  LEU N CD1 1 
ATOM   2497 C CD2 . LEU B 2 71  ? 139.778 143.073 172.030 1.00 91.39  ? 33  LEU N CD2 1 
ATOM   2498 N N   . TYR B 2 72  ? 140.617 138.821 170.569 1.00 79.42  ? 34  TYR N N   1 
ATOM   2499 C CA  . TYR B 2 72  ? 141.152 137.464 170.600 1.00 82.62  ? 34  TYR N CA  1 
ATOM   2500 C C   . TYR B 2 72  ? 141.654 137.065 171.984 1.00 85.65  ? 34  TYR N C   1 
ATOM   2501 O O   . TYR B 2 72  ? 141.157 136.101 172.572 1.00 93.57  ? 34  TYR N O   1 
ATOM   2502 C CB  . TYR B 2 72  ? 142.267 137.331 169.557 1.00 85.16  ? 34  TYR N CB  1 
ATOM   2503 C CG  . TYR B 2 72  ? 141.761 137.415 168.137 1.00 84.41  ? 34  TYR N CG  1 
ATOM   2504 C CD1 . TYR B 2 72  ? 140.878 136.468 167.639 1.00 84.05  ? 34  TYR N CD1 1 
ATOM   2505 C CD2 . TYR B 2 72  ? 142.148 138.451 167.302 1.00 84.66  ? 34  TYR N CD2 1 
ATOM   2506 C CE1 . TYR B 2 72  ? 140.407 136.544 166.345 1.00 84.15  ? 34  TYR N CE1 1 
ATOM   2507 C CE2 . TYR B 2 72  ? 141.683 138.535 166.007 1.00 83.30  ? 34  TYR N CE2 1 
ATOM   2508 C CZ  . TYR B 2 72  ? 140.812 137.580 165.533 1.00 84.68  ? 34  TYR N CZ  1 
ATOM   2509 O OH  . TYR B 2 72  ? 140.345 137.660 164.242 1.00 85.15  ? 34  TYR N OH  1 
ATOM   2510 N N   . ASP B 2 73  ? 142.628 137.794 172.521 1.00 90.30  ? 35  ASP N N   1 
ATOM   2511 C CA  . ASP B 2 73  ? 143.182 137.514 173.837 1.00 91.67  ? 35  ASP N CA  1 
ATOM   2512 C C   . ASP B 2 73  ? 143.148 138.779 174.677 1.00 94.97  ? 35  ASP N C   1 
ATOM   2513 O O   . ASP B 2 73  ? 143.453 139.867 174.184 1.00 106.70 ? 35  ASP N O   1 
ATOM   2514 C CB  . ASP B 2 73  ? 144.625 136.999 173.752 1.00 93.32  ? 35  ASP N CB  1 
ATOM   2515 C CG  . ASP B 2 73  ? 144.709 135.562 173.284 1.00 96.26  ? 35  ASP N CG  1 
ATOM   2516 O OD1 . ASP B 2 73  ? 143.790 135.105 172.576 1.00 99.04  ? 35  ASP N OD1 1 
ATOM   2517 O OD2 . ASP B 2 73  ? 145.700 134.885 173.628 1.00 97.95  ? 35  ASP N OD2 1 
ATOM   2518 N N   . MET B 2 74  ? 142.771 138.634 175.945 1.00 94.69  ? 36  MET N N   1 
ATOM   2519 C CA  . MET B 2 74  ? 142.770 139.747 176.884 1.00 97.37  ? 36  MET N CA  1 
ATOM   2520 C C   . MET B 2 74  ? 143.431 139.294 178.175 1.00 99.59  ? 36  MET N C   1 
ATOM   2521 O O   . MET B 2 74  ? 143.072 138.248 178.720 1.00 107.15 ? 36  MET N O   1 
ATOM   2522 C CB  . MET B 2 74  ? 141.347 140.245 177.163 1.00 100.51 ? 36  MET N CB  1 
ATOM   2523 C CG  . MET B 2 74  ? 140.431 140.257 175.950 1.00 104.09 ? 36  MET N CG  1 
ATOM   2524 S SD  . MET B 2 74  ? 138.967 141.280 176.189 1.00 113.86 ? 36  MET N SD  1 
ATOM   2525 C CE  . MET B 2 74  ? 139.718 142.860 176.572 1.00 104.41 ? 36  MET N CE  1 
ATOM   2526 N N   . GLY B 2 75  ? 144.389 140.079 178.663 1.00 100.59 ? 37  GLY N N   1 
ATOM   2527 C CA  . GLY B 2 75  ? 145.116 139.680 179.855 1.00 103.71 ? 37  GLY N CA  1 
ATOM   2528 C C   . GLY B 2 75  ? 145.742 140.859 180.564 1.00 103.91 ? 37  GLY N C   1 
ATOM   2529 O O   . GLY B 2 75  ? 145.837 141.965 180.028 1.00 105.93 ? 37  GLY N O   1 
ATOM   2530 N N   . TRP B 2 76  ? 146.175 140.596 181.793 1.00 117.54 ? 38  TRP N N   1 
ATOM   2531 C CA  . TRP B 2 76  ? 146.826 141.584 182.640 1.00 117.16 ? 38  TRP N CA  1 
ATOM   2532 C C   . TRP B 2 76  ? 148.302 141.242 182.781 1.00 119.17 ? 38  TRP N C   1 
ATOM   2533 O O   . TRP B 2 76  ? 148.670 140.066 182.856 1.00 123.93 ? 38  TRP N O   1 
ATOM   2534 C CB  . TRP B 2 76  ? 146.168 141.645 184.020 1.00 118.41 ? 38  TRP N CB  1 
ATOM   2535 C CG  . TRP B 2 76  ? 144.726 142.038 183.971 1.00 122.20 ? 38  TRP N CG  1 
ATOM   2536 C CD1 . TRP B 2 76  ? 143.666 141.233 183.672 1.00 121.13 ? 38  TRP N CD1 1 
ATOM   2537 C CD2 . TRP B 2 76  ? 144.184 143.339 184.222 1.00 123.40 ? 38  TRP N CD2 1 
ATOM   2538 N NE1 . TRP B 2 76  ? 142.498 141.952 183.725 1.00 122.02 ? 38  TRP N NE1 1 
ATOM   2539 C CE2 . TRP B 2 76  ? 142.789 143.248 184.060 1.00 121.70 ? 38  TRP N CE2 1 
ATOM   2540 C CE3 . TRP B 2 76  ? 144.744 144.571 184.570 1.00 122.36 ? 38  TRP N CE3 1 
ATOM   2541 C CZ2 . TRP B 2 76  ? 141.947 144.341 184.234 1.00 120.42 ? 38  TRP N CZ2 1 
ATOM   2542 C CZ3 . TRP B 2 76  ? 143.907 145.654 184.741 1.00 120.17 ? 38  TRP N CZ3 1 
ATOM   2543 C CH2 . TRP B 2 76  ? 142.524 145.533 184.572 1.00 120.29 ? 38  TRP N CH2 1 
ATOM   2544 N N   . TYR B 2 77  ? 149.141 142.268 182.818 1.00 122.57 ? 39  TYR N N   1 
ATOM   2545 C CA  . TYR B 2 77  ? 150.586 142.100 182.841 1.00 123.14 ? 39  TYR N CA  1 
ATOM   2546 C C   . TYR B 2 77  ? 151.189 142.896 183.995 1.00 125.54 ? 39  TYR N C   1 
ATOM   2547 O O   . TYR B 2 77  ? 150.503 143.644 184.695 1.00 127.24 ? 39  TYR N O   1 
ATOM   2548 C CB  . TYR B 2 77  ? 151.197 142.528 181.505 1.00 123.72 ? 39  TYR N CB  1 
ATOM   2549 C CG  . TYR B 2 77  ? 151.273 141.420 180.482 1.00 123.77 ? 39  TYR N CG  1 
ATOM   2550 C CD1 . TYR B 2 77  ? 152.373 140.576 180.423 1.00 123.68 ? 39  TYR N CD1 1 
ATOM   2551 C CD2 . TYR B 2 77  ? 150.242 141.214 179.577 1.00 123.81 ? 39  TYR N CD2 1 
ATOM   2552 C CE1 . TYR B 2 77  ? 152.446 139.563 179.487 1.00 124.60 ? 39  TYR N CE1 1 
ATOM   2553 C CE2 . TYR B 2 77  ? 150.304 140.203 178.640 1.00 124.26 ? 39  TYR N CE2 1 
ATOM   2554 C CZ  . TYR B 2 77  ? 151.408 139.380 178.599 1.00 124.96 ? 39  TYR N CZ  1 
ATOM   2555 O OH  . TYR B 2 77  ? 151.473 138.371 177.666 1.00 124.78 ? 39  TYR N OH  1 
ATOM   2556 N N   . ARG B 2 78  ? 152.493 142.722 184.183 1.00 135.65 ? 40  ARG N N   1 
ATOM   2557 C CA  . ARG B 2 78  ? 153.243 143.445 185.203 1.00 135.37 ? 40  ARG N CA  1 
ATOM   2558 C C   . ARG B 2 78  ? 154.733 143.418 184.874 1.00 135.16 ? 40  ARG N C   1 
ATOM   2559 O O   . ARG B 2 78  ? 155.125 143.115 183.748 1.00 135.84 ? 40  ARG N O   1 
ATOM   2560 C CB  . ARG B 2 78  ? 152.990 142.848 186.590 1.00 133.92 ? 40  ARG N CB  1 
ATOM   2561 C CG  . ARG B 2 78  ? 153.918 143.361 187.686 1.00 133.23 ? 40  ARG N CG  1 
ATOM   2562 C CD  . ARG B 2 78  ? 153.930 144.881 187.763 1.00 134.76 ? 40  ARG N CD  1 
ATOM   2563 N NE  . ARG B 2 78  ? 155.148 145.443 187.192 1.00 134.85 ? 40  ARG N NE  1 
ATOM   2564 C CZ  . ARG B 2 78  ? 155.287 146.707 186.813 1.00 134.67 ? 40  ARG N CZ  1 
ATOM   2565 N NH1 . ARG B 2 78  ? 154.298 147.577 186.935 1.00 134.68 ? 40  ARG N NH1 1 
ATOM   2566 N NH2 . ARG B 2 78  ? 156.446 147.106 186.298 1.00 133.86 ? 40  ARG N NH2 1 
ATOM   2567 N N   . GLN B 2 84  ? 159.393 144.676 182.882 1.00 145.46 ? 46  GLN N N   1 
ATOM   2568 C CA  . GLN B 2 84  ? 159.168 144.032 181.594 1.00 146.71 ? 46  GLN N CA  1 
ATOM   2569 C C   . GLN B 2 84  ? 157.702 143.656 181.413 1.00 145.97 ? 46  GLN N C   1 
ATOM   2570 O O   . GLN B 2 84  ? 156.807 144.376 181.856 1.00 144.72 ? 46  GLN N O   1 
ATOM   2571 C CB  . GLN B 2 84  ? 160.049 142.789 181.455 1.00 146.16 ? 46  GLN N CB  1 
ATOM   2572 C CG  . GLN B 2 84  ? 161.370 143.038 180.746 1.00 146.38 ? 46  GLN N CG  1 
ATOM   2573 C CD  . GLN B 2 84  ? 161.224 143.071 179.237 1.00 146.03 ? 46  GLN N CD  1 
ATOM   2574 O OE1 . GLN B 2 84  ? 160.194 142.674 178.693 1.00 145.19 ? 46  GLN N OE1 1 
ATOM   2575 N NE2 . GLN B 2 84  ? 162.259 143.544 178.552 1.00 146.75 ? 46  GLN N NE2 1 
ATOM   2576 N N   . ARG B 2 85  ? 157.464 142.526 180.756 1.00 137.17 ? 47  ARG N N   1 
ATOM   2577 C CA  . ARG B 2 85  ? 156.119 142.022 180.486 1.00 135.10 ? 47  ARG N CA  1 
ATOM   2578 C C   . ARG B 2 85  ? 155.943 140.724 181.272 1.00 135.02 ? 47  ARG N C   1 
ATOM   2579 O O   . ARG B 2 85  ? 156.212 139.634 180.765 1.00 134.23 ? 47  ARG N O   1 
ATOM   2580 C CB  . ARG B 2 85  ? 155.902 141.802 178.989 1.00 133.80 ? 47  ARG N CB  1 
ATOM   2581 C CG  . ARG B 2 85  ? 155.212 142.951 178.269 1.00 133.29 ? 47  ARG N CG  1 
ATOM   2582 C CD  . ARG B 2 85  ? 156.052 144.217 178.303 1.00 133.59 ? 47  ARG N CD  1 
ATOM   2583 N NE  . ARG B 2 85  ? 155.507 145.257 177.439 1.00 133.40 ? 47  ARG N NE  1 
ATOM   2584 C CZ  . ARG B 2 85  ? 156.060 146.448 177.258 1.00 134.75 ? 47  ARG N CZ  1 
ATOM   2585 N NH1 . ARG B 2 85  ? 157.180 146.790 177.873 1.00 136.37 ? 47  ARG N NH1 1 
ATOM   2586 N NH2 . ARG B 2 85  ? 155.475 147.318 176.440 1.00 133.54 ? 47  ARG N NH2 1 
ATOM   2587 N N   . GLU B 2 86  ? 155.489 140.849 182.516 1.00 139.15 ? 48  GLU N N   1 
ATOM   2588 C CA  . GLU B 2 86  ? 155.248 139.694 183.372 1.00 139.04 ? 48  GLU N CA  1 
ATOM   2589 C C   . GLU B 2 86  ? 153.806 139.236 183.198 1.00 139.06 ? 48  GLU N C   1 
ATOM   2590 O O   . GLU B 2 86  ? 152.872 139.950 183.577 1.00 137.65 ? 48  GLU N O   1 
ATOM   2591 C CB  . GLU B 2 86  ? 155.535 140.034 184.834 1.00 137.26 ? 48  GLU N CB  1 
ATOM   2592 C CG  . GLU B 2 86  ? 155.056 138.982 185.820 1.00 137.34 ? 48  GLU N CG  1 
ATOM   2593 C CD  . GLU B 2 86  ? 155.191 139.431 187.262 1.00 139.89 ? 48  GLU N CD  1 
ATOM   2594 O OE1 . GLU B 2 86  ? 155.712 140.542 187.493 1.00 139.93 ? 48  GLU N OE1 1 
ATOM   2595 O OE2 . GLU B 2 86  ? 154.774 138.673 188.163 1.00 140.69 ? 48  GLU N OE2 1 
ATOM   2596 N N   . LEU B 2 87  ? 153.627 138.046 182.629 1.00 134.35 ? 49  LEU N N   1 
ATOM   2597 C CA  . LEU B 2 87  ? 152.295 137.507 182.371 1.00 131.75 ? 49  LEU N CA  1 
ATOM   2598 C C   . LEU B 2 87  ? 151.733 136.938 183.666 1.00 132.20 ? 49  LEU N C   1 
ATOM   2599 O O   . LEU B 2 87  ? 152.162 135.874 184.124 1.00 134.49 ? 49  LEU N O   1 
ATOM   2600 C CB  . LEU B 2 87  ? 152.353 136.441 181.281 1.00 129.99 ? 49  LEU N CB  1 
ATOM   2601 N N   . VAL B 2 88  ? 150.771 137.641 184.257 1.00 122.16 ? 50  VAL N N   1 
ATOM   2602 C CA  . VAL B 2 88  ? 150.134 137.185 185.483 1.00 122.51 ? 50  VAL N CA  1 
ATOM   2603 C C   . VAL B 2 88  ? 148.765 136.563 185.231 1.00 120.07 ? 50  VAL N C   1 
ATOM   2604 O O   . VAL B 2 88  ? 148.318 135.744 186.050 1.00 122.91 ? 50  VAL N O   1 
ATOM   2605 C CB  . VAL B 2 88  ? 150.023 138.331 186.513 1.00 123.11 ? 50  VAL N CB  1 
ATOM   2606 C CG1 . VAL B 2 88  ? 148.957 139.334 186.096 1.00 123.08 ? 50  VAL N CG1 1 
ATOM   2607 C CG2 . VAL B 2 88  ? 149.750 137.787 187.909 1.00 122.10 ? 50  VAL N CG2 1 
ATOM   2608 N N   . ALA B 2 89  ? 148.103 136.894 184.123 1.00 101.93 ? 51  ALA N N   1 
ATOM   2609 C CA  . ALA B 2 89  ? 146.804 136.331 183.789 1.00 104.16 ? 51  ALA N CA  1 
ATOM   2610 C C   . ALA B 2 89  ? 146.473 136.689 182.350 1.00 105.06 ? 51  ALA N C   1 
ATOM   2611 O O   . ALA B 2 89  ? 146.805 137.784 181.890 1.00 109.31 ? 51  ALA N O   1 
ATOM   2612 C CB  . ALA B 2 89  ? 145.707 136.850 184.728 1.00 105.06 ? 51  ALA N CB  1 
ATOM   2613 N N   . SER B 2 90  ? 145.826 135.762 181.649 1.00 98.30  ? 52  SER N N   1 
ATOM   2614 C CA  . SER B 2 90  ? 145.391 136.002 180.275 1.00 97.29  ? 52  SER N CA  1 
ATOM   2615 C C   . SER B 2 90  ? 144.344 134.960 179.923 1.00 100.05 ? 52  SER N C   1 
ATOM   2616 O O   . SER B 2 90  ? 144.630 133.759 179.971 1.00 100.99 ? 52  SER N O   1 
ATOM   2617 C CB  . SER B 2 90  ? 146.569 135.936 179.304 1.00 96.50  ? 52  SER N CB  1 
ATOM   2618 N N   . ILE B 2 91  ? 143.145 135.408 179.564 1.00 109.49 ? 53  ILE N N   1 
ATOM   2619 C CA  . ILE B 2 91  ? 142.042 134.520 179.218 1.00 107.13 ? 53  ILE N CA  1 
ATOM   2620 C C   . ILE B 2 91  ? 141.761 134.656 177.727 1.00 106.50 ? 53  ILE N C   1 
ATOM   2621 O O   . ILE B 2 91  ? 141.497 135.759 177.231 1.00 109.92 ? 53  ILE N O   1 
ATOM   2622 C CB  . ILE B 2 91  ? 140.786 134.803 180.062 1.00 110.25 ? 53  ILE N CB  1 
ATOM   2623 C CG1 . ILE B 2 91  ? 139.687 133.784 179.749 1.00 113.26 ? 53  ILE N CG1 1 
ATOM   2624 C CG2 . ILE B 2 91  ? 140.303 136.247 179.912 1.00 109.10 ? 53  ILE N CG2 1 
ATOM   2625 C CD1 . ILE B 2 91  ? 138.547 133.787 180.745 1.00 113.11 ? 53  ILE N CD1 1 
ATOM   2626 N N   . THR B 2 92  ? 141.850 133.542 177.010 1.00 98.12  ? 54  THR N N   1 
ATOM   2627 C CA  . THR B 2 92  ? 141.510 133.531 175.599 1.00 101.46 ? 54  THR N CA  1 
ATOM   2628 C C   . THR B 2 92  ? 139.993 133.640 175.440 1.00 101.47 ? 54  THR N C   1 
ATOM   2629 O O   . THR B 2 92  ? 139.228 133.468 176.394 1.00 103.09 ? 54  THR N O   1 
ATOM   2630 C CB  . THR B 2 92  ? 142.051 132.261 174.938 1.00 103.99 ? 54  THR N CB  1 
ATOM   2631 O OG1 . THR B 2 92  ? 143.385 132.020 175.399 1.00 102.81 ? 54  THR N OG1 1 
ATOM   2632 C CG2 . THR B 2 92  ? 142.094 132.404 173.421 1.00 102.16 ? 54  THR N CG2 1 
ATOM   2633 N N   . SER B 2 93  ? 139.555 133.949 174.217 1.00 95.14  ? 55  SER N N   1 
ATOM   2634 C CA  . SER B 2 93  ? 138.123 134.016 173.943 1.00 94.65  ? 55  SER N CA  1 
ATOM   2635 C C   . SER B 2 93  ? 137.434 132.688 174.235 1.00 96.37  ? 55  SER N C   1 
ATOM   2636 O O   . SER B 2 93  ? 136.232 132.662 174.521 1.00 95.22  ? 55  SER N O   1 
ATOM   2637 C CB  . SER B 2 93  ? 137.886 134.431 172.491 1.00 93.04  ? 55  SER N CB  1 
ATOM   2638 O OG  . SER B 2 93  ? 138.737 133.716 171.613 1.00 94.08  ? 55  SER N OG  1 
ATOM   2639 N N   . GLY B 2 94  ? 138.173 131.582 174.171 1.00 100.47 ? 56  GLY N N   1 
ATOM   2640 C CA  . GLY B 2 94  ? 137.657 130.279 174.528 1.00 99.82  ? 56  GLY N CA  1 
ATOM   2641 C C   . GLY B 2 94  ? 137.724 129.932 175.996 1.00 100.83 ? 56  GLY N C   1 
ATOM   2642 O O   . GLY B 2 94  ? 137.319 128.833 176.382 1.00 103.68 ? 56  GLY N O   1 
ATOM   2643 N N   . GLY B 2 95  ? 138.227 130.837 176.833 1.00 102.22 ? 57  GLY N N   1 
ATOM   2644 C CA  . GLY B 2 95  ? 138.293 130.613 178.261 1.00 102.70 ? 57  GLY N CA  1 
ATOM   2645 C C   . GLY B 2 95  ? 139.504 129.851 178.750 1.00 102.87 ? 57  GLY N C   1 
ATOM   2646 O O   . GLY B 2 95  ? 139.593 129.575 179.953 1.00 102.40 ? 57  GLY N O   1 
ATOM   2647 N N   . SER B 2 96  ? 140.441 129.502 177.867 1.00 107.99 ? 58  SER N N   1 
ATOM   2648 C CA  . SER B 2 96  ? 141.641 128.761 178.258 1.00 109.79 ? 58  SER N CA  1 
ATOM   2649 C C   . SER B 2 96  ? 142.638 129.736 178.879 1.00 112.54 ? 58  SER N C   1 
ATOM   2650 O O   . SER B 2 96  ? 143.533 130.274 178.222 1.00 113.27 ? 58  SER N O   1 
ATOM   2651 C CB  . SER B 2 96  ? 142.236 128.032 177.060 1.00 107.77 ? 58  SER N CB  1 
ATOM   2652 N N   . THR B 2 97  ? 142.473 129.963 180.179 1.00 120.12 ? 59  THR N N   1 
ATOM   2653 C CA  . THR B 2 97  ? 143.324 130.902 180.895 1.00 119.29 ? 59  THR N CA  1 
ATOM   2654 C C   . THR B 2 97  ? 144.730 130.338 181.076 1.00 120.02 ? 59  THR N C   1 
ATOM   2655 O O   . THR B 2 97  ? 144.941 129.123 181.098 1.00 119.60 ? 59  THR N O   1 
ATOM   2656 C CB  . THR B 2 97  ? 142.726 131.232 182.260 1.00 117.87 ? 59  THR N CB  1 
ATOM   2657 O OG1 . THR B 2 97  ? 142.980 130.151 183.164 1.00 118.76 ? 59  THR N OG1 1 
ATOM   2658 C CG2 . THR B 2 97  ? 141.226 131.436 182.142 1.00 117.02 ? 59  THR N CG2 1 
ATOM   2659 N N   . LYS B 2 98  ? 145.700 131.245 181.208 1.00 113.62 ? 60  LYS N N   1 
ATOM   2660 C CA  . LYS B 2 98  ? 147.104 130.895 181.431 1.00 112.76 ? 60  LYS N CA  1 
ATOM   2661 C C   . LYS B 2 98  ? 147.607 131.732 182.603 1.00 112.72 ? 60  LYS N C   1 
ATOM   2662 O O   . LYS B 2 98  ? 148.166 132.814 182.410 1.00 115.71 ? 60  LYS N O   1 
ATOM   2663 C CB  . LYS B 2 98  ? 147.934 131.126 180.172 1.00 111.58 ? 60  LYS N CB  1 
ATOM   2664 N N   . TYR B 2 99  ? 147.417 131.224 183.817 1.00 119.35 ? 61  TYR N N   1 
ATOM   2665 C CA  . TYR B 2 99  ? 147.782 131.965 185.012 1.00 121.77 ? 61  TYR N CA  1 
ATOM   2666 C C   . TYR B 2 99  ? 149.294 131.960 185.218 1.00 122.46 ? 61  TYR N C   1 
ATOM   2667 O O   . TYR B 2 99  ? 150.021 131.120 184.680 1.00 122.40 ? 61  TYR N O   1 
ATOM   2668 C CB  . TYR B 2 99  ? 147.081 131.382 186.238 1.00 121.63 ? 61  TYR N CB  1 
ATOM   2669 C CG  . TYR B 2 99  ? 145.626 131.769 186.337 1.00 121.94 ? 61  TYR N CG  1 
ATOM   2670 C CD1 . TYR B 2 99  ? 145.251 133.027 186.785 1.00 124.38 ? 61  TYR N CD1 1 
ATOM   2671 C CD2 . TYR B 2 99  ? 144.626 130.879 185.974 1.00 122.64 ? 61  TYR N CD2 1 
ATOM   2672 C CE1 . TYR B 2 99  ? 143.922 133.387 186.872 1.00 125.15 ? 61  TYR N CE1 1 
ATOM   2673 C CE2 . TYR B 2 99  ? 143.294 131.229 186.059 1.00 122.80 ? 61  TYR N CE2 1 
ATOM   2674 C CZ  . TYR B 2 99  ? 142.948 132.483 186.508 1.00 123.51 ? 61  TYR N CZ  1 
ATOM   2675 O OH  . TYR B 2 99  ? 141.621 132.835 186.593 1.00 123.15 ? 61  TYR N OH  1 
ATOM   2676 N N   . GLY B 2 100 ? 149.764 132.924 186.010 1.00 131.92 ? 62  GLY N N   1 
ATOM   2677 C CA  . GLY B 2 100 ? 151.176 133.029 186.304 1.00 131.87 ? 62  GLY N CA  1 
ATOM   2678 C C   . GLY B 2 100 ? 151.632 132.045 187.365 1.00 133.99 ? 62  GLY N C   1 
ATOM   2679 O O   . GLY B 2 100 ? 150.840 131.482 188.120 1.00 133.90 ? 62  GLY N O   1 
ATOM   2680 N N   . ASP B 2 101 ? 152.950 131.840 187.411 1.00 148.28 ? 63  ASP N N   1 
ATOM   2681 C CA  . ASP B 2 101 ? 153.523 130.909 188.379 1.00 148.73 ? 63  ASP N CA  1 
ATOM   2682 C C   . ASP B 2 101 ? 153.350 131.413 189.807 1.00 148.17 ? 63  ASP N C   1 
ATOM   2683 O O   . ASP B 2 101 ? 153.046 130.629 190.714 1.00 148.13 ? 63  ASP N O   1 
ATOM   2684 C CB  . ASP B 2 101 ? 155.001 130.673 188.068 1.00 147.15 ? 63  ASP N CB  1 
ATOM   2685 N N   . SER B 2 102 ? 153.541 132.713 190.027 1.00 144.36 ? 64  SER N N   1 
ATOM   2686 C CA  . SER B 2 102 ? 153.431 133.284 191.363 1.00 143.37 ? 64  SER N CA  1 
ATOM   2687 C C   . SER B 2 102 ? 151.991 133.432 191.832 1.00 143.79 ? 64  SER N C   1 
ATOM   2688 O O   . SER B 2 102 ? 151.766 133.636 193.030 1.00 143.87 ? 64  SER N O   1 
ATOM   2689 C CB  . SER B 2 102 ? 154.126 134.647 191.411 1.00 143.23 ? 64  SER N CB  1 
ATOM   2690 N N   . VAL B 2 103 ? 151.019 133.336 190.930 1.00 147.30 ? 65  VAL N N   1 
ATOM   2691 C CA  . VAL B 2 103 ? 149.613 133.475 191.279 1.00 147.32 ? 65  VAL N CA  1 
ATOM   2692 C C   . VAL B 2 103 ? 148.842 132.186 190.999 1.00 150.12 ? 65  VAL N C   1 
ATOM   2693 O O   . VAL B 2 103 ? 147.624 132.218 190.831 1.00 151.85 ? 65  VAL N O   1 
ATOM   2694 C CB  . VAL B 2 103 ? 148.976 134.673 190.556 1.00 146.93 ? 65  VAL N CB  1 
ATOM   2695 N N   . LYS B 2 104 ? 149.536 131.051 190.942 1.00 153.31 ? 66  LYS N N   1 
ATOM   2696 C CA  . LYS B 2 104 ? 148.879 129.774 190.694 1.00 152.40 ? 66  LYS N CA  1 
ATOM   2697 C C   . LYS B 2 104 ? 147.957 129.435 191.858 1.00 152.58 ? 66  LYS N C   1 
ATOM   2698 O O   . LYS B 2 104 ? 148.410 129.295 192.999 1.00 150.52 ? 66  LYS N O   1 
ATOM   2699 C CB  . LYS B 2 104 ? 149.919 128.675 190.492 1.00 149.91 ? 66  LYS N CB  1 
ATOM   2700 N N   . GLY B 2 105 ? 146.664 129.305 191.571 1.00 156.73 ? 67  GLY N N   1 
ATOM   2701 C CA  . GLY B 2 105 ? 145.682 129.070 192.608 1.00 155.45 ? 67  GLY N CA  1 
ATOM   2702 C C   . GLY B 2 105 ? 145.353 130.276 193.454 1.00 156.09 ? 67  GLY N C   1 
ATOM   2703 O O   . GLY B 2 105 ? 144.731 130.121 194.511 1.00 156.52 ? 67  GLY N O   1 
ATOM   2704 N N   . ARG B 2 106 ? 145.749 131.471 193.027 1.00 155.97 ? 68  ARG N N   1 
ATOM   2705 C CA  . ARG B 2 106 ? 145.572 132.692 193.802 1.00 155.13 ? 68  ARG N CA  1 
ATOM   2706 C C   . ARG B 2 106 ? 144.628 133.691 193.154 1.00 154.93 ? 68  ARG N C   1 
ATOM   2707 O O   . ARG B 2 106 ? 143.794 134.280 193.847 1.00 154.02 ? 68  ARG N O   1 
ATOM   2708 C CB  . ARG B 2 106 ? 146.935 133.359 194.036 1.00 154.07 ? 68  ARG N CB  1 
ATOM   2709 C CG  . ARG B 2 106 ? 147.765 132.705 195.125 1.00 153.70 ? 68  ARG N CG  1 
ATOM   2710 C CD  . ARG B 2 106 ? 147.506 133.367 196.465 1.00 154.75 ? 68  ARG N CD  1 
ATOM   2711 N NE  . ARG B 2 106 ? 148.041 134.723 196.504 1.00 155.86 ? 68  ARG N NE  1 
ATOM   2712 C CZ  . ARG B 2 106 ? 147.337 135.796 196.838 1.00 155.11 ? 68  ARG N CZ  1 
ATOM   2713 N NH1 . ARG B 2 106 ? 146.056 135.710 197.156 1.00 155.48 ? 68  ARG N NH1 1 
ATOM   2714 N NH2 . ARG B 2 106 ? 147.933 136.985 196.849 1.00 154.24 ? 68  ARG N NH2 1 
ATOM   2715 N N   . PHE B 2 107 ? 144.734 133.900 191.846 1.00 145.55 ? 69  PHE N N   1 
ATOM   2716 C CA  . PHE B 2 107 ? 143.925 134.877 191.136 1.00 144.82 ? 69  PHE N CA  1 
ATOM   2717 C C   . PHE B 2 107 ? 142.866 134.179 190.293 1.00 142.28 ? 69  PHE N C   1 
ATOM   2718 O O   . PHE B 2 107 ? 143.051 133.045 189.844 1.00 140.86 ? 69  PHE N O   1 
ATOM   2719 C CB  . PHE B 2 107 ? 144.793 135.766 190.239 1.00 145.60 ? 69  PHE N CB  1 
ATOM   2720 C CG  . PHE B 2 107 ? 145.566 136.815 190.986 1.00 146.23 ? 69  PHE N CG  1 
ATOM   2721 C CD1 . PHE B 2 107 ? 145.222 137.159 192.283 1.00 146.23 ? 69  PHE N CD1 1 
ATOM   2722 C CD2 . PHE B 2 107 ? 146.637 137.460 190.390 1.00 144.45 ? 69  PHE N CD2 1 
ATOM   2723 C CE1 . PHE B 2 107 ? 145.932 138.125 192.971 1.00 144.93 ? 69  PHE N CE1 1 
ATOM   2724 C CE2 . PHE B 2 107 ? 147.351 138.426 191.073 1.00 144.36 ? 69  PHE N CE2 1 
ATOM   2725 C CZ  . PHE B 2 107 ? 146.998 138.759 192.365 1.00 144.49 ? 69  PHE N CZ  1 
ATOM   2726 N N   . THR B 2 108 ? 141.747 134.871 190.090 1.00 134.21 ? 70  THR N N   1 
ATOM   2727 C CA  . THR B 2 108 ? 140.655 134.390 189.255 1.00 135.74 ? 70  THR N CA  1 
ATOM   2728 C C   . THR B 2 108 ? 140.343 135.439 188.198 1.00 134.21 ? 70  THR N C   1 
ATOM   2729 O O   . THR B 2 108 ? 140.204 136.624 188.518 1.00 134.17 ? 70  THR N O   1 
ATOM   2730 C CB  . THR B 2 108 ? 139.408 134.089 190.093 1.00 135.76 ? 70  THR N CB  1 
ATOM   2731 O OG1 . THR B 2 108 ? 139.710 133.064 191.048 1.00 136.31 ? 70  THR N OG1 1 
ATOM   2732 C CG2 . THR B 2 108 ? 138.266 133.620 189.202 1.00 134.68 ? 70  THR N CG2 1 
ATOM   2733 N N   . ILE B 2 109 ? 140.240 135.005 186.946 1.00 122.67 ? 71  ILE N N   1 
ATOM   2734 C CA  . ILE B 2 109 ? 139.975 135.901 185.834 1.00 121.69 ? 71  ILE N CA  1 
ATOM   2735 C C   . ILE B 2 109 ? 138.572 135.638 185.304 1.00 121.17 ? 71  ILE N C   1 
ATOM   2736 O O   . ILE B 2 109 ? 137.959 134.598 185.565 1.00 123.83 ? 71  ILE N O   1 
ATOM   2737 C CB  . ILE B 2 109 ? 141.030 135.752 184.713 1.00 124.18 ? 71  ILE N CB  1 
ATOM   2738 C CG1 . ILE B 2 109 ? 141.229 137.081 183.981 1.00 125.79 ? 71  ILE N CG1 1 
ATOM   2739 C CG2 . ILE B 2 109 ? 140.627 134.657 183.744 1.00 123.07 ? 71  ILE N CG2 1 
ATOM   2740 C CD1 . ILE B 2 109 ? 142.417 137.091 183.044 1.00 122.57 ? 71  ILE N CD1 1 
ATOM   2741 N N   . SER B 2 110 ? 138.051 136.602 184.548 1.00 118.07 ? 72  SER N N   1 
ATOM   2742 C CA  . SER B 2 110 ? 136.724 136.497 183.962 1.00 120.23 ? 72  SER N CA  1 
ATOM   2743 C C   . SER B 2 110 ? 136.657 137.406 182.745 1.00 118.16 ? 72  SER N C   1 
ATOM   2744 O O   . SER B 2 110 ? 137.515 138.267 182.539 1.00 119.66 ? 72  SER N O   1 
ATOM   2745 C CB  . SER B 2 110 ? 135.631 136.856 184.975 1.00 121.72 ? 72  SER N CB  1 
ATOM   2746 O OG  . SER B 2 110 ? 134.357 136.899 184.356 1.00 122.22 ? 72  SER N OG  1 
ATOM   2747 N N   . ARG B 2 111 ? 135.623 137.205 181.932 1.00 110.37 ? 73  ARG N N   1 
ATOM   2748 C CA  . ARG B 2 111 ? 135.440 137.999 180.727 1.00 110.46 ? 73  ARG N CA  1 
ATOM   2749 C C   . ARG B 2 111 ? 133.967 138.023 180.350 1.00 110.90 ? 73  ARG N C   1 
ATOM   2750 O O   . ARG B 2 111 ? 133.281 137.000 180.428 1.00 110.67 ? 73  ARG N O   1 
ATOM   2751 C CB  . ARG B 2 111 ? 136.269 137.447 179.562 1.00 110.91 ? 73  ARG N CB  1 
ATOM   2752 C CG  . ARG B 2 111 ? 136.080 138.203 178.258 1.00 112.61 ? 73  ARG N CG  1 
ATOM   2753 C CD  . ARG B 2 111 ? 136.916 137.611 177.141 1.00 112.08 ? 73  ARG N CD  1 
ATOM   2754 N NE  . ARG B 2 111 ? 136.602 138.218 175.853 1.00 112.26 ? 73  ARG N NE  1 
ATOM   2755 C CZ  . ARG B 2 111 ? 137.341 138.085 174.761 1.00 112.17 ? 73  ARG N CZ  1 
ATOM   2756 N NH1 . ARG B 2 111 ? 138.451 137.364 174.761 1.00 112.88 ? 73  ARG N NH1 1 
ATOM   2757 N NH2 . ARG B 2 111 ? 136.957 138.688 173.640 1.00 110.65 ? 73  ARG N NH2 1 
ATOM   2758 N N   . ASP B 2 112 ? 133.491 139.196 179.942 1.00 125.95 ? 74  ASP N N   1 
ATOM   2759 C CA  . ASP B 2 112 ? 132.133 139.380 179.433 1.00 127.26 ? 74  ASP N CA  1 
ATOM   2760 C C   . ASP B 2 112 ? 132.252 139.793 177.970 1.00 126.76 ? 74  ASP N C   1 
ATOM   2761 O O   . ASP B 2 112 ? 132.583 140.944 177.669 1.00 127.62 ? 74  ASP N O   1 
ATOM   2762 C CB  . ASP B 2 112 ? 131.372 140.420 180.252 1.00 127.37 ? 74  ASP N CB  1 
ATOM   2763 C CG  . ASP B 2 112 ? 129.963 140.655 179.736 1.00 126.27 ? 74  ASP N CG  1 
ATOM   2764 O OD1 . ASP B 2 112 ? 129.466 139.830 178.941 1.00 125.45 ? 74  ASP N OD1 1 
ATOM   2765 O OD2 . ASP B 2 112 ? 129.352 141.672 180.127 1.00 125.49 ? 74  ASP N OD2 1 
ATOM   2766 N N   . ASN B 2 113 ? 131.984 138.852 177.062 1.00 121.92 ? 75  ASN N N   1 
ATOM   2767 C CA  . ASN B 2 113 ? 132.075 139.155 175.638 1.00 120.99 ? 75  ASN N CA  1 
ATOM   2768 C C   . ASN B 2 113 ? 131.057 140.207 175.222 1.00 121.28 ? 75  ASN N C   1 
ATOM   2769 O O   . ASN B 2 113 ? 131.309 140.978 174.289 1.00 121.29 ? 75  ASN N O   1 
ATOM   2770 C CB  . ASN B 2 113 ? 131.887 137.880 174.817 1.00 122.25 ? 75  ASN N CB  1 
ATOM   2771 C CG  . ASN B 2 113 ? 133.181 137.115 174.626 1.00 122.06 ? 75  ASN N CG  1 
ATOM   2772 O OD1 . ASN B 2 113 ? 134.269 137.681 174.728 1.00 120.63 ? 75  ASN N OD1 1 
ATOM   2773 N ND2 . ASN B 2 113 ? 133.069 135.822 174.346 1.00 122.80 ? 75  ASN N ND2 1 
ATOM   2774 N N   . ALA B 2 114 ? 129.904 140.251 175.893 1.00 125.23 ? 76  ALA N N   1 
ATOM   2775 C CA  . ALA B 2 114 ? 128.878 141.226 175.537 1.00 127.69 ? 76  ALA N CA  1 
ATOM   2776 C C   . ALA B 2 114 ? 129.357 142.651 175.780 1.00 129.21 ? 76  ALA N C   1 
ATOM   2777 O O   . ALA B 2 114 ? 129.162 143.532 174.935 1.00 128.67 ? 76  ALA N O   1 
ATOM   2778 C CB  . ALA B 2 114 ? 127.597 140.948 176.322 1.00 127.19 ? 76  ALA N CB  1 
ATOM   2779 N N   . LYS B 2 115 ? 129.984 142.898 176.927 1.00 130.55 ? 77  LYS N N   1 
ATOM   2780 C CA  . LYS B 2 115 ? 130.486 144.223 177.265 1.00 130.80 ? 77  LYS N CA  1 
ATOM   2781 C C   . LYS B 2 115 ? 131.960 144.408 176.925 1.00 131.04 ? 77  LYS N C   1 
ATOM   2782 O O   . LYS B 2 115 ? 132.490 145.506 177.126 1.00 129.35 ? 77  LYS N O   1 
ATOM   2783 C CB  . LYS B 2 115 ? 130.264 144.506 178.754 1.00 128.57 ? 77  LYS N CB  1 
ATOM   2784 N N   . ASN B 2 116 ? 132.623 143.371 176.407 1.00 122.35 ? 78  ASN N N   1 
ATOM   2785 C CA  . ASN B 2 116 ? 134.049 143.421 176.077 1.00 118.08 ? 78  ASN N CA  1 
ATOM   2786 C C   . ASN B 2 116 ? 134.877 143.849 177.287 1.00 116.24 ? 78  ASN N C   1 
ATOM   2787 O O   . ASN B 2 116 ? 135.734 144.731 177.206 1.00 116.93 ? 78  ASN N O   1 
ATOM   2788 C CB  . ASN B 2 116 ? 134.303 144.342 174.881 1.00 116.24 ? 78  ASN N CB  1 
ATOM   2789 C CG  . ASN B 2 116 ? 134.093 143.642 173.556 1.00 116.59 ? 78  ASN N CG  1 
ATOM   2790 O OD1 . ASN B 2 116 ? 133.731 142.468 173.513 1.00 117.33 ? 78  ASN N OD1 1 
ATOM   2791 N ND2 . ASN B 2 116 ? 134.318 144.362 172.464 1.00 117.32 ? 78  ASN N ND2 1 
ATOM   2792 N N   . THR B 2 117 ? 134.609 143.210 178.424 1.00 115.77 ? 79  THR N N   1 
ATOM   2793 C CA  . THR B 2 117 ? 135.256 143.541 179.684 1.00 119.28 ? 79  THR N CA  1 
ATOM   2794 C C   . THR B 2 117 ? 135.905 142.300 180.279 1.00 118.97 ? 79  THR N C   1 
ATOM   2795 O O   . THR B 2 117 ? 135.438 141.177 180.077 1.00 118.46 ? 79  THR N O   1 
ATOM   2796 C CB  . THR B 2 117 ? 134.259 144.126 180.693 1.00 119.91 ? 79  THR N CB  1 
ATOM   2797 O OG1 . THR B 2 117 ? 133.235 143.161 180.964 1.00 117.95 ? 79  THR N OG1 1 
ATOM   2798 C CG2 . THR B 2 117 ? 133.623 145.391 180.147 1.00 118.70 ? 79  THR N CG2 1 
ATOM   2799 N N   . VAL B 2 118 ? 136.992 142.518 181.017 1.00 118.50 ? 80  VAL N N   1 
ATOM   2800 C CA  . VAL B 2 118 ? 137.697 141.455 181.718 1.00 117.14 ? 80  VAL N CA  1 
ATOM   2801 C C   . VAL B 2 118 ? 137.833 141.836 183.186 1.00 115.85 ? 80  VAL N C   1 
ATOM   2802 O O   . VAL B 2 118 ? 138.189 142.968 183.529 1.00 115.66 ? 80  VAL N O   1 
ATOM   2803 C CB  . VAL B 2 118 ? 139.078 141.160 181.093 1.00 116.29 ? 80  VAL N CB  1 
ATOM   2804 C CG1 . VAL B 2 118 ? 138.901 140.528 179.730 1.00 117.90 ? 80  VAL N CG1 1 
ATOM   2805 C CG2 . VAL B 2 118 ? 139.897 142.433 180.979 1.00 115.68 ? 80  VAL N CG2 1 
ATOM   2806 N N   . TYR B 2 119 ? 137.534 140.876 184.056 1.00 124.48 ? 81  TYR N N   1 
ATOM   2807 C CA  . TYR B 2 119 ? 137.496 141.094 185.494 1.00 124.72 ? 81  TYR N CA  1 
ATOM   2808 C C   . TYR B 2 119 ? 138.539 140.221 186.172 1.00 123.84 ? 81  TYR N C   1 
ATOM   2809 O O   . TYR B 2 119 ? 138.683 139.042 185.832 1.00 126.39 ? 81  TYR N O   1 
ATOM   2810 C CB  . TYR B 2 119 ? 136.106 140.787 186.056 1.00 127.19 ? 81  TYR N CB  1 
ATOM   2811 C CG  . TYR B 2 119 ? 134.982 141.463 185.305 1.00 127.83 ? 81  TYR N CG  1 
ATOM   2812 C CD1 . TYR B 2 119 ? 134.866 142.846 185.288 1.00 127.24 ? 81  TYR N CD1 1 
ATOM   2813 C CD2 . TYR B 2 119 ? 134.041 140.718 184.608 1.00 125.41 ? 81  TYR N CD2 1 
ATOM   2814 C CE1 . TYR B 2 119 ? 133.841 143.468 184.603 1.00 126.67 ? 81  TYR N CE1 1 
ATOM   2815 C CE2 . TYR B 2 119 ? 133.013 141.331 183.920 1.00 124.29 ? 81  TYR N CE2 1 
ATOM   2816 C CZ  . TYR B 2 119 ? 132.918 142.705 183.921 1.00 126.05 ? 81  TYR N CZ  1 
ATOM   2817 O OH  . TYR B 2 119 ? 131.896 143.321 183.236 1.00 127.35 ? 81  TYR N OH  1 
ATOM   2818 N N   . LEU B 2 120 ? 139.260 140.800 187.127 1.00 129.66 ? 82  LEU N N   1 
ATOM   2819 C CA  . LEU B 2 120 ? 140.270 140.092 187.905 1.00 131.40 ? 82  LEU N CA  1 
ATOM   2820 C C   . LEU B 2 120 ? 139.816 140.060 189.359 1.00 133.96 ? 82  LEU N C   1 
ATOM   2821 O O   . LEU B 2 120 ? 139.746 141.104 190.016 1.00 133.24 ? 82  LEU N O   1 
ATOM   2822 C CB  . LEU B 2 120 ? 141.634 140.764 187.766 1.00 130.76 ? 82  LEU N CB  1 
ATOM   2823 C CG  . LEU B 2 120 ? 142.829 140.006 188.345 1.00 132.48 ? 82  LEU N CG  1 
ATOM   2824 C CD1 . LEU B 2 120 ? 143.187 138.819 187.465 1.00 131.07 ? 82  LEU N CD1 1 
ATOM   2825 C CD2 . LEU B 2 120 ? 144.020 140.936 188.508 1.00 132.50 ? 82  LEU N CD2 1 
ATOM   2826 N N   . GLN B 2 121 ? 139.510 138.866 189.859 1.00 141.84 ? 83  GLN N N   1 
ATOM   2827 C CA  . GLN B 2 121 ? 139.074 138.692 191.239 1.00 140.52 ? 83  GLN N CA  1 
ATOM   2828 C C   . GLN B 2 121 ? 140.294 138.530 192.138 1.00 140.25 ? 83  GLN N C   1 
ATOM   2829 O O   . GLN B 2 121 ? 141.017 137.533 192.041 1.00 137.95 ? 83  GLN N O   1 
ATOM   2830 C CB  . GLN B 2 121 ? 138.142 137.488 191.368 1.00 140.17 ? 83  GLN N CB  1 
ATOM   2831 C CG  . GLN B 2 121 ? 136.732 137.732 190.848 1.00 141.95 ? 83  GLN N CG  1 
ATOM   2832 C CD  . GLN B 2 121 ? 136.600 137.483 189.359 1.00 142.36 ? 83  GLN N CD  1 
ATOM   2833 O OE1 . GLN B 2 121 ? 137.426 136.800 188.755 1.00 141.97 ? 83  GLN N OE1 1 
ATOM   2834 N NE2 . GLN B 2 121 ? 135.554 138.038 188.757 1.00 141.07 ? 83  GLN N NE2 1 
ATOM   2835 N N   . MET B 2 122 ? 140.518 139.511 193.006 1.00 159.23 ? 84  MET N N   1 
ATOM   2836 C CA  . MET B 2 122 ? 141.635 139.492 193.937 1.00 159.30 ? 84  MET N CA  1 
ATOM   2837 C C   . MET B 2 122 ? 141.178 139.031 195.315 1.00 160.30 ? 84  MET N C   1 
ATOM   2838 O O   . MET B 2 122 ? 140.070 139.341 195.762 1.00 160.77 ? 84  MET N O   1 
ATOM   2839 C CB  . MET B 2 122 ? 142.278 140.877 194.030 1.00 159.24 ? 84  MET N CB  1 
ATOM   2840 C CG  . MET B 2 122 ? 141.285 141.997 194.295 1.00 160.32 ? 84  MET N CG  1 
ATOM   2841 S SD  . MET B 2 122 ? 142.051 143.618 194.485 1.00 162.49 ? 84  MET N SD  1 
ATOM   2842 C CE  . MET B 2 122 ? 142.570 143.543 196.194 1.00 159.86 ? 84  MET N CE  1 
ATOM   2843 N N   . SER B 2 123 ? 142.050 138.283 195.988 1.00 162.89 ? 85  SER N N   1 
ATOM   2844 C CA  . SER B 2 123 ? 141.750 137.754 197.310 1.00 162.77 ? 85  SER N CA  1 
ATOM   2845 C C   . SER B 2 123 ? 143.054 137.369 197.991 1.00 163.13 ? 85  SER N C   1 
ATOM   2846 O O   . SER B 2 123 ? 144.020 136.997 197.321 1.00 163.55 ? 85  SER N O   1 
ATOM   2847 C CB  . SER B 2 123 ? 140.813 136.542 197.227 1.00 162.33 ? 85  SER N CB  1 
ATOM   2848 O OG  . SER B 2 123 ? 141.422 135.475 196.520 1.00 161.35 ? 85  SER N OG  1 
ATOM   2849 N N   . SER B 2 124 ? 143.068 137.462 199.323 1.00 169.67 ? 86  SER N N   1 
ATOM   2850 C CA  . SER B 2 124 ? 144.230 137.116 200.143 1.00 170.40 ? 86  SER N CA  1 
ATOM   2851 C C   . SER B 2 124 ? 145.454 137.937 199.722 1.00 170.92 ? 86  SER N C   1 
ATOM   2852 O O   . SER B 2 124 ? 146.459 137.419 199.231 1.00 170.52 ? 86  SER N O   1 
ATOM   2853 C CB  . SER B 2 124 ? 144.517 135.611 200.078 1.00 170.64 ? 86  SER N CB  1 
ATOM   2854 O OG  . SER B 2 124 ? 145.811 135.317 200.575 1.00 170.13 ? 86  SER N OG  1 
ATOM   2855 N N   . LEU B 2 125 ? 145.329 139.246 199.928 1.00 177.71 ? 87  LEU N N   1 
ATOM   2856 C CA  . LEU B 2 125 ? 146.380 140.175 199.537 1.00 178.29 ? 87  LEU N CA  1 
ATOM   2857 C C   . LEU B 2 125 ? 147.678 139.883 200.280 1.00 177.87 ? 87  LEU N C   1 
ATOM   2858 O O   . LEU B 2 125 ? 147.681 139.480 201.446 1.00 178.13 ? 87  LEU N O   1 
ATOM   2859 C CB  . LEU B 2 125 ? 145.947 141.616 199.807 1.00 178.82 ? 87  LEU N CB  1 
ATOM   2860 C CG  . LEU B 2 125 ? 145.003 142.258 198.793 1.00 178.19 ? 87  LEU N CG  1 
ATOM   2861 C CD1 . LEU B 2 125 ? 144.153 143.325 199.462 1.00 177.40 ? 87  LEU N CD1 1 
ATOM   2862 C CD2 . LEU B 2 125 ? 145.804 142.848 197.644 1.00 177.14 ? 87  LEU N CD2 1 
ATOM   2863 N N   . LYS B 2 126 ? 148.790 140.092 199.584 1.00 174.54 ? 88  LYS N N   1 
ATOM   2864 C CA  . LYS B 2 126 ? 150.122 139.958 200.143 1.00 174.63 ? 88  LYS N CA  1 
ATOM   2865 C C   . LYS B 2 126 ? 150.913 141.228 199.872 1.00 175.11 ? 88  LYS N C   1 
ATOM   2866 O O   . LYS B 2 126 ? 150.694 141.895 198.856 1.00 174.70 ? 88  LYS N O   1 
ATOM   2867 C CB  . LYS B 2 126 ? 150.861 138.752 199.543 1.00 173.84 ? 88  LYS N CB  1 
ATOM   2868 N N   . PRO B 2 127 ? 151.829 141.594 200.773 1.00 175.96 ? 89  PRO N N   1 
ATOM   2869 C CA  . PRO B 2 127 ? 152.626 142.812 200.547 1.00 175.82 ? 89  PRO N CA  1 
ATOM   2870 C C   . PRO B 2 127 ? 153.451 142.767 199.275 1.00 176.10 ? 89  PRO N C   1 
ATOM   2871 O O   . PRO B 2 127 ? 153.685 143.816 198.661 1.00 175.76 ? 89  PRO N O   1 
ATOM   2872 C CB  . PRO B 2 127 ? 153.515 142.884 201.796 1.00 175.79 ? 89  PRO N CB  1 
ATOM   2873 C CG  . PRO B 2 127 ? 152.790 142.084 202.830 1.00 175.52 ? 89  PRO N CG  1 
ATOM   2874 C CD  . PRO B 2 127 ? 152.109 140.980 202.081 1.00 175.44 ? 89  PRO N CD  1 
ATOM   2875 N N   . GLU B 2 128 ? 153.901 141.582 198.857 1.00 178.43 ? 90  GLU N N   1 
ATOM   2876 C CA  . GLU B 2 128 ? 154.709 141.472 197.649 1.00 178.95 ? 90  GLU N CA  1 
ATOM   2877 C C   . GLU B 2 128 ? 153.893 141.675 196.379 1.00 178.71 ? 90  GLU N C   1 
ATOM   2878 O O   . GLU B 2 128 ? 154.477 141.837 195.303 1.00 177.87 ? 90  GLU N O   1 
ATOM   2879 C CB  . GLU B 2 128 ? 155.403 140.110 197.607 1.00 178.00 ? 90  GLU N CB  1 
ATOM   2880 C CG  . GLU B 2 128 ? 156.221 139.796 198.848 1.00 177.51 ? 90  GLU N CG  1 
ATOM   2881 C CD  . GLU B 2 128 ? 155.484 138.893 199.817 1.00 177.97 ? 90  GLU N CD  1 
ATOM   2882 O OE1 . GLU B 2 128 ? 154.411 138.371 199.446 1.00 177.83 ? 90  GLU N OE1 1 
ATOM   2883 O OE2 . GLU B 2 128 ? 155.975 138.706 200.950 1.00 178.70 ? 90  GLU N OE2 1 
ATOM   2884 N N   . ASP B 2 129 ? 152.566 141.670 196.478 1.00 171.94 ? 91  ASP N N   1 
ATOM   2885 C CA  . ASP B 2 129 ? 151.699 141.830 195.319 1.00 170.33 ? 91  ASP N CA  1 
ATOM   2886 C C   . ASP B 2 129 ? 151.347 143.284 195.033 1.00 170.48 ? 91  ASP N C   1 
ATOM   2887 O O   . ASP B 2 129 ? 150.598 143.550 194.087 1.00 170.04 ? 91  ASP N O   1 
ATOM   2888 C CB  . ASP B 2 129 ? 150.414 141.018 195.508 1.00 171.12 ? 91  ASP N CB  1 
ATOM   2889 C CG  . ASP B 2 129 ? 150.670 139.524 195.547 1.00 171.82 ? 91  ASP N CG  1 
ATOM   2890 O OD1 . ASP B 2 129 ? 151.685 139.079 194.971 1.00 171.13 ? 91  ASP N OD1 1 
ATOM   2891 O OD2 . ASP B 2 129 ? 149.857 138.796 196.153 1.00 171.71 ? 91  ASP N OD2 1 
ATOM   2892 N N   . THR B 2 130 ? 151.862 144.226 195.820 1.00 168.89 ? 92  THR N N   1 
ATOM   2893 C CA  . THR B 2 130 ? 151.607 145.643 195.585 1.00 168.75 ? 92  THR N CA  1 
ATOM   2894 C C   . THR B 2 130 ? 152.361 146.088 194.338 1.00 168.41 ? 92  THR N C   1 
ATOM   2895 O O   . THR B 2 130 ? 153.582 146.270 194.373 1.00 167.82 ? 92  THR N O   1 
ATOM   2896 C CB  . THR B 2 130 ? 152.028 146.466 196.798 1.00 168.00 ? 92  THR N CB  1 
ATOM   2897 O OG1 . THR B 2 130 ? 151.259 146.066 197.940 1.00 168.65 ? 92  THR N OG1 1 
ATOM   2898 C CG2 . THR B 2 130 ? 151.809 147.950 196.540 1.00 167.69 ? 92  THR N CG2 1 
ATOM   2899 N N   . ALA B 2 131 ? 151.639 146.263 193.235 1.00 158.89 ? 93  ALA N N   1 
ATOM   2900 C CA  . ALA B 2 131 ? 152.248 146.651 191.969 1.00 157.89 ? 93  ALA N CA  1 
ATOM   2901 C C   . ALA B 2 131 ? 151.183 147.306 191.100 1.00 157.41 ? 93  ALA N C   1 
ATOM   2902 O O   . ALA B 2 131 ? 150.016 147.414 191.485 1.00 157.27 ? 93  ALA N O   1 
ATOM   2903 C CB  . ALA B 2 131 ? 152.884 145.447 191.269 1.00 156.86 ? 93  ALA N CB  1 
ATOM   2904 N N   . VAL B 2 132 ? 151.599 147.745 189.914 1.00 146.35 ? 94  VAL N N   1 
ATOM   2905 C CA  . VAL B 2 132 ? 150.718 148.377 188.940 1.00 145.67 ? 94  VAL N CA  1 
ATOM   2906 C C   . VAL B 2 132 ? 150.482 147.393 187.804 1.00 143.87 ? 94  VAL N C   1 
ATOM   2907 O O   . VAL B 2 132 ? 151.437 146.856 187.231 1.00 143.42 ? 94  VAL N O   1 
ATOM   2908 C CB  . VAL B 2 132 ? 151.311 149.695 188.413 1.00 146.30 ? 94  VAL N CB  1 
ATOM   2909 C CG1 . VAL B 2 132 ? 150.343 150.366 187.451 1.00 145.15 ? 94  VAL N CG1 1 
ATOM   2910 C CG2 . VAL B 2 132 ? 151.650 150.622 189.571 1.00 144.98 ? 94  VAL N CG2 1 
ATOM   2911 N N   . TYR B 2 133 ? 149.215 147.162 187.477 1.00 138.48 ? 95  TYR N N   1 
ATOM   2912 C CA  . TYR B 2 133 ? 148.824 146.179 186.478 1.00 138.30 ? 95  TYR N CA  1 
ATOM   2913 C C   . TYR B 2 133 ? 148.401 146.876 185.193 1.00 135.42 ? 95  TYR N C   1 
ATOM   2914 O O   . TYR B 2 133 ? 147.720 147.905 185.228 1.00 135.71 ? 95  TYR N O   1 
ATOM   2915 C CB  . TYR B 2 133 ? 147.685 145.297 186.997 1.00 141.24 ? 95  TYR N CB  1 
ATOM   2916 C CG  . TYR B 2 133 ? 148.081 144.410 188.156 1.00 141.71 ? 95  TYR N CG  1 
ATOM   2917 C CD1 . TYR B 2 133 ? 148.013 144.871 189.465 1.00 140.76 ? 95  TYR N CD1 1 
ATOM   2918 C CD2 . TYR B 2 133 ? 148.524 143.111 187.942 1.00 140.26 ? 95  TYR N CD2 1 
ATOM   2919 C CE1 . TYR B 2 133 ? 148.375 144.065 190.527 1.00 139.56 ? 95  TYR N CE1 1 
ATOM   2920 C CE2 . TYR B 2 133 ? 148.887 142.297 188.999 1.00 140.15 ? 95  TYR N CE2 1 
ATOM   2921 C CZ  . TYR B 2 133 ? 148.811 142.779 190.288 1.00 140.31 ? 95  TYR N CZ  1 
ATOM   2922 O OH  . TYR B 2 133 ? 149.172 141.972 191.342 1.00 139.97 ? 95  TYR N OH  1 
ATOM   2923 N N   . TYR B 2 134 ? 148.813 146.312 184.062 1.00 122.68 ? 96  TYR N N   1 
ATOM   2924 C CA  . TYR B 2 134 ? 148.493 146.845 182.745 1.00 124.91 ? 96  TYR N CA  1 
ATOM   2925 C C   . TYR B 2 134 ? 147.590 145.867 182.007 1.00 124.51 ? 96  TYR N C   1 
ATOM   2926 O O   . TYR B 2 134 ? 147.933 144.689 181.862 1.00 125.93 ? 96  TYR N O   1 
ATOM   2927 C CB  . TYR B 2 134 ? 149.764 147.100 181.932 1.00 125.90 ? 96  TYR N CB  1 
ATOM   2928 C CG  . TYR B 2 134 ? 150.618 148.232 182.452 1.00 127.50 ? 96  TYR N CG  1 
ATOM   2929 C CD1 . TYR B 2 134 ? 151.530 148.025 183.479 1.00 127.20 ? 96  TYR N CD1 1 
ATOM   2930 C CD2 . TYR B 2 134 ? 150.515 149.508 181.915 1.00 126.38 ? 96  TYR N CD2 1 
ATOM   2931 C CE1 . TYR B 2 134 ? 152.313 149.058 183.958 1.00 125.54 ? 96  TYR N CE1 1 
ATOM   2932 C CE2 . TYR B 2 134 ? 151.294 150.547 182.388 1.00 124.86 ? 96  TYR N CE2 1 
ATOM   2933 C CZ  . TYR B 2 134 ? 152.191 150.316 183.409 1.00 125.28 ? 96  TYR N CZ  1 
ATOM   2934 O OH  . TYR B 2 134 ? 152.969 151.348 183.881 1.00 126.63 ? 96  TYR N OH  1 
ATOM   2935 N N   . CYS B 2 135 ? 146.444 146.355 181.541 1.00 110.78 ? 97  CYS N N   1 
ATOM   2936 C CA  . CYS B 2 135 ? 145.533 145.535 180.753 1.00 106.59 ? 97  CYS N CA  1 
ATOM   2937 C C   . CYS B 2 135 ? 146.076 145.399 179.337 1.00 107.36 ? 97  CYS N C   1 
ATOM   2938 O O   . CYS B 2 135 ? 146.425 146.399 178.701 1.00 110.30 ? 97  CYS N O   1 
ATOM   2939 C CB  . CYS B 2 135 ? 144.134 146.146 180.737 1.00 108.51 ? 97  CYS N CB  1 
ATOM   2940 S SG  . CYS B 2 135 ? 143.004 145.385 179.546 1.00 116.10 ? 97  CYS N SG  1 
ATOM   2941 N N   . ASN B 2 136 ? 146.149 144.166 178.846 1.00 98.19  ? 98  ASN N N   1 
ATOM   2942 C CA  . ASN B 2 136 ? 146.643 143.870 177.509 1.00 96.76  ? 98  ASN N CA  1 
ATOM   2943 C C   . ASN B 2 136 ? 145.566 143.115 176.747 1.00 98.30  ? 98  ASN N C   1 
ATOM   2944 O O   . ASN B 2 136 ? 144.929 142.213 177.299 1.00 103.35 ? 98  ASN N O   1 
ATOM   2945 C CB  . ASN B 2 136 ? 147.934 143.049 177.572 1.00 99.57  ? 98  ASN N CB  1 
ATOM   2946 C CG  . ASN B 2 136 ? 148.586 142.867 176.214 1.00 100.51 ? 98  ASN N CG  1 
ATOM   2947 O OD1 . ASN B 2 136 ? 147.980 143.129 175.176 1.00 101.81 ? 98  ASN N OD1 1 
ATOM   2948 N ND2 . ASN B 2 136 ? 149.834 142.413 176.216 1.00 99.12  ? 98  ASN N ND2 1 
ATOM   2949 N N   . ALA B 2 137 ? 145.364 143.484 175.486 1.00 81.01  ? 99  ALA N N   1 
ATOM   2950 C CA  . ALA B 2 137 ? 144.359 142.841 174.656 1.00 81.54  ? 99  ALA N CA  1 
ATOM   2951 C C   . ALA B 2 137 ? 144.846 142.775 173.218 1.00 77.42  ? 99  ALA N C   1 
ATOM   2952 O O   . ALA B 2 137 ? 145.610 143.630 172.764 1.00 83.07  ? 99  ALA N O   1 
ATOM   2953 C CB  . ALA B 2 137 ? 143.016 143.578 174.718 1.00 82.41  ? 99  ALA N CB  1 
ATOM   2954 N N   . GLU B 2 138 ? 144.394 141.748 172.507 1.00 77.21  ? 100 GLU N N   1 
ATOM   2955 C CA  . GLU B 2 138 ? 144.667 141.580 171.088 1.00 80.25  ? 100 GLU N CA  1 
ATOM   2956 C C   . GLU B 2 138 ? 143.356 141.686 170.325 1.00 83.01  ? 100 GLU N C   1 
ATOM   2957 O O   . GLU B 2 138 ? 142.388 140.990 170.650 1.00 85.62  ? 100 GLU N O   1 
ATOM   2958 C CB  . GLU B 2 138 ? 145.338 140.235 170.808 1.00 82.28  ? 100 GLU N CB  1 
ATOM   2959 C CG  . GLU B 2 138 ? 146.728 140.104 171.400 1.00 84.71  ? 100 GLU N CG  1 
ATOM   2960 C CD  . GLU B 2 138 ? 147.348 138.749 171.128 1.00 88.67  ? 100 GLU N CD  1 
ATOM   2961 O OE1 . GLU B 2 138 ? 146.650 137.877 170.571 1.00 90.63  ? 100 GLU N OE1 1 
ATOM   2962 O OE2 . GLU B 2 138 ? 148.532 138.556 171.472 1.00 88.49  ? 100 GLU N OE2 1 
ATOM   2963 N N   . TYR B 2 139 ? 143.326 142.549 169.317 1.00 83.31  ? 101 TYR N N   1 
ATOM   2964 C CA  . TYR B 2 139 ? 142.105 142.847 168.586 1.00 82.31  ? 101 TYR N CA  1 
ATOM   2965 C C   . TYR B 2 139 ? 142.393 142.842 167.092 1.00 81.90  ? 101 TYR N C   1 
ATOM   2966 O O   . TYR B 2 139 ? 143.533 142.673 166.652 1.00 88.25  ? 101 TYR N O   1 
ATOM   2967 C CB  . TYR B 2 139 ? 141.518 144.195 169.022 1.00 84.46  ? 101 TYR N CB  1 
ATOM   2968 C CG  . TYR B 2 139 ? 142.398 145.382 168.699 1.00 84.31  ? 101 TYR N CG  1 
ATOM   2969 C CD1 . TYR B 2 139 ? 143.416 145.770 169.559 1.00 86.87  ? 101 TYR N CD1 1 
ATOM   2970 C CD2 . TYR B 2 139 ? 142.205 146.120 167.540 1.00 84.90  ? 101 TYR N CD2 1 
ATOM   2971 C CE1 . TYR B 2 139 ? 144.221 146.852 169.269 1.00 86.63  ? 101 TYR N CE1 1 
ATOM   2972 C CE2 . TYR B 2 139 ? 143.005 147.204 167.243 1.00 86.43  ? 101 TYR N CE2 1 
ATOM   2973 C CZ  . TYR B 2 139 ? 144.011 147.566 168.111 1.00 88.13  ? 101 TYR N CZ  1 
ATOM   2974 O OH  . TYR B 2 139 ? 144.811 148.646 167.820 1.00 91.22  ? 101 TYR N OH  1 
ATOM   2975 N N   . ARG B 2 140 ? 141.335 143.029 166.309 1.00 78.09  ? 102 ARG N N   1 
ATOM   2976 C CA  . ARG B 2 140 ? 141.450 143.154 164.865 1.00 77.89  ? 102 ARG N CA  1 
ATOM   2977 C C   . ARG B 2 140 ? 140.405 144.151 164.391 1.00 80.98  ? 102 ARG N C   1 
ATOM   2978 O O   . ARG B 2 140 ? 139.284 144.171 164.904 1.00 84.67  ? 102 ARG N O   1 
ATOM   2979 C CB  . ARG B 2 140 ? 141.266 141.802 164.172 1.00 77.06  ? 102 ARG N CB  1 
ATOM   2980 C CG  . ARG B 2 140 ? 141.817 141.751 162.763 1.00 81.57  ? 102 ARG N CG  1 
ATOM   2981 C CD  . ARG B 2 140 ? 141.923 140.322 162.273 1.00 80.09  ? 102 ARG N CD  1 
ATOM   2982 N NE  . ARG B 2 140 ? 143.256 139.777 162.487 1.00 76.43  ? 102 ARG N NE  1 
ATOM   2983 C CZ  . ARG B 2 140 ? 143.509 138.500 162.737 1.00 79.58  ? 102 ARG N CZ  1 
ATOM   2984 N NH1 . ARG B 2 140 ? 142.538 137.606 162.813 1.00 82.20  ? 102 ARG N NH1 1 
ATOM   2985 N NH2 . ARG B 2 140 ? 144.767 138.111 162.916 1.00 81.23  ? 102 ARG N NH2 1 
ATOM   2986 N N   . THR B 2 141 ? 140.782 144.986 163.424 1.00 80.72  ? 103 THR N N   1 
ATOM   2987 C CA  . THR B 2 141 ? 139.896 146.024 162.916 1.00 81.21  ? 103 THR N CA  1 
ATOM   2988 C C   . THR B 2 141 ? 139.131 145.610 161.666 1.00 81.13  ? 103 THR N C   1 
ATOM   2989 O O   . THR B 2 141 ? 138.268 146.368 161.212 1.00 84.69  ? 103 THR N O   1 
ATOM   2990 C CB  . THR B 2 141 ? 140.689 147.302 162.619 1.00 87.38  ? 103 THR N CB  1 
ATOM   2991 O OG1 . THR B 2 141 ? 141.843 146.980 161.834 1.00 86.30  ? 103 THR N OG1 1 
ATOM   2992 C CG2 . THR B 2 141 ? 141.131 147.967 163.914 1.00 89.38  ? 103 THR N CG2 1 
ATOM   2993 N N   . GLY B 2 142 ? 139.419 144.444 161.104 1.00 70.82  ? 104 GLY N N   1 
ATOM   2994 C CA  . GLY B 2 142 ? 138.734 144.009 159.900 1.00 68.74  ? 104 GLY N CA  1 
ATOM   2995 C C   . GLY B 2 142 ? 139.179 142.616 159.519 1.00 67.98  ? 104 GLY N C   1 
ATOM   2996 O O   . GLY B 2 142 ? 140.157 142.081 160.051 1.00 69.53  ? 104 GLY N O   1 
ATOM   2997 N N   . ILE B 2 143 ? 138.437 142.033 158.575 1.00 69.03  ? 105 ILE N N   1 
ATOM   2998 C CA  . ILE B 2 143 ? 138.732 140.675 158.129 1.00 67.45  ? 105 ILE N CA  1 
ATOM   2999 C C   . ILE B 2 143 ? 140.115 140.608 157.498 1.00 68.23  ? 105 ILE N C   1 
ATOM   3000 O O   . ILE B 2 143 ? 140.888 139.677 157.755 1.00 71.10  ? 105 ILE N O   1 
ATOM   3001 C CB  . ILE B 2 143 ? 137.645 140.184 157.154 1.00 64.96  ? 105 ILE N CB  1 
ATOM   3002 C CG1 . ILE B 2 143 ? 136.271 140.225 157.819 1.00 71.24  ? 105 ILE N CG1 1 
ATOM   3003 C CG2 . ILE B 2 143 ? 137.951 138.777 156.684 1.00 64.40  ? 105 ILE N CG2 1 
ATOM   3004 C CD1 . ILE B 2 143 ? 135.126 139.991 156.859 1.00 71.08  ? 105 ILE N CD1 1 
ATOM   3005 N N   . TRP B 2 144 ? 140.451 141.591 156.668 1.00 63.26  ? 106 TRP N N   1 
ATOM   3006 C CA  . TRP B 2 144 ? 141.703 141.595 155.925 1.00 59.57  ? 106 TRP N CA  1 
ATOM   3007 C C   . TRP B 2 144 ? 142.822 142.337 156.642 1.00 60.60  ? 106 TRP N C   1 
ATOM   3008 O O   . TRP B 2 144 ? 143.906 142.490 156.072 1.00 61.31  ? 106 TRP N O   1 
ATOM   3009 C CB  . TRP B 2 144 ? 141.482 142.205 154.538 1.00 62.03  ? 106 TRP N CB  1 
ATOM   3010 C CG  . TRP B 2 144 ? 140.201 141.759 153.907 1.00 66.31  ? 106 TRP N CG  1 
ATOM   3011 C CD1 . TRP B 2 144 ? 139.033 142.459 153.843 1.00 66.52  ? 106 TRP N CD1 1 
ATOM   3012 C CD2 . TRP B 2 144 ? 139.954 140.505 153.264 1.00 63.12  ? 106 TRP N CD2 1 
ATOM   3013 N NE1 . TRP B 2 144 ? 138.075 141.721 153.193 1.00 62.88  ? 106 TRP N NE1 1 
ATOM   3014 C CE2 . TRP B 2 144 ? 138.615 140.516 152.828 1.00 63.79  ? 106 TRP N CE2 1 
ATOM   3015 C CE3 . TRP B 2 144 ? 140.735 139.374 153.011 1.00 58.07  ? 106 TRP N CE3 1 
ATOM   3016 C CZ2 . TRP B 2 144 ? 138.042 139.442 152.155 1.00 60.01  ? 106 TRP N CZ2 1 
ATOM   3017 C CZ3 . TRP B 2 144 ? 140.164 138.310 152.343 1.00 59.28  ? 106 TRP N CZ3 1 
ATOM   3018 C CH2 . TRP B 2 144 ? 138.831 138.351 151.923 1.00 60.37  ? 106 TRP N CH2 1 
ATOM   3019 N N   . GLU B 2 145 ? 142.590 142.802 157.864 1.00 72.69  ? 107 GLU N N   1 
ATOM   3020 C CA  . GLU B 2 145 ? 143.621 143.474 158.638 1.00 73.83  ? 107 GLU N CA  1 
ATOM   3021 C C   . GLU B 2 145 ? 144.401 142.464 159.468 1.00 71.50  ? 107 GLU N C   1 
ATOM   3022 O O   . GLU B 2 145 ? 143.881 141.415 159.854 1.00 76.52  ? 107 GLU N O   1 
ATOM   3023 C CB  . GLU B 2 145 ? 143.008 144.538 159.550 1.00 78.90  ? 107 GLU N CB  1 
ATOM   3024 C CG  . GLU B 2 145 ? 141.996 145.439 158.862 1.00 80.15  ? 107 GLU N CG  1 
ATOM   3025 C CD  . GLU B 2 145 ? 142.632 146.347 157.829 1.00 80.78  ? 107 GLU N CD  1 
ATOM   3026 O OE1 . GLU B 2 145 ? 143.727 146.883 158.101 1.00 80.46  ? 107 GLU N OE1 1 
ATOM   3027 O OE2 . GLU B 2 145 ? 142.038 146.524 156.744 1.00 77.34  ? 107 GLU N OE2 1 
ATOM   3028 N N   . GLU B 2 146 ? 145.660 142.793 159.741 1.00 77.50  ? 108 GLU N N   1 
ATOM   3029 C CA  . GLU B 2 146 ? 146.525 141.913 160.508 1.00 85.02  ? 108 GLU N CA  1 
ATOM   3030 C C   . GLU B 2 146 ? 146.144 141.952 161.987 1.00 86.51  ? 108 GLU N C   1 
ATOM   3031 O O   . GLU B 2 146 ? 145.191 142.619 162.398 1.00 86.45  ? 108 GLU N O   1 
ATOM   3032 C CB  . GLU B 2 146 ? 147.988 142.299 160.305 1.00 85.10  ? 108 GLU N CB  1 
ATOM   3033 C CG  . GLU B 2 146 ? 148.329 143.704 160.771 1.00 88.69  ? 108 GLU N CG  1 
ATOM   3034 C CD  . GLU B 2 146 ? 149.823 143.954 160.821 1.00 87.03  ? 108 GLU N CD  1 
ATOM   3035 O OE1 . GLU B 2 146 ? 150.491 143.398 161.718 1.00 85.56  ? 108 GLU N OE1 1 
ATOM   3036 O OE2 . GLU B 2 146 ? 150.330 144.707 159.963 1.00 85.45  ? 108 GLU N OE2 1 
ATOM   3037 N N   . LEU B 2 147 ? 146.897 141.217 162.801 1.00 82.10  ? 109 LEU N N   1 
ATOM   3038 C CA  . LEU B 2 147 ? 146.642 141.152 164.234 1.00 78.48  ? 109 LEU N CA  1 
ATOM   3039 C C   . LEU B 2 147 ? 147.264 142.365 164.916 1.00 76.66  ? 109 LEU N C   1 
ATOM   3040 O O   . LEU B 2 147 ? 148.479 142.572 164.837 1.00 78.90  ? 109 LEU N O   1 
ATOM   3041 C CB  . LEU B 2 147 ? 147.203 139.856 164.812 1.00 80.14  ? 109 LEU N CB  1 
ATOM   3042 C CG  . LEU B 2 147 ? 146.921 139.561 166.284 1.00 74.80  ? 109 LEU N CG  1 
ATOM   3043 C CD1 . LEU B 2 147 ? 145.439 139.358 166.507 1.00 76.90  ? 109 LEU N CD1 1 
ATOM   3044 C CD2 . LEU B 2 147 ? 147.699 138.343 166.741 1.00 75.10  ? 109 LEU N CD2 1 
ATOM   3045 N N   . LEU B 2 148 ? 146.437 143.161 165.586 1.00 81.54  ? 110 LEU N N   1 
ATOM   3046 C CA  . LEU B 2 148 ? 146.883 144.370 166.262 1.00 82.47  ? 110 LEU N CA  1 
ATOM   3047 C C   . LEU B 2 148 ? 146.840 144.176 167.771 1.00 80.80  ? 110 LEU N C   1 
ATOM   3048 O O   . LEU B 2 148 ? 145.830 143.730 168.323 1.00 81.24  ? 110 LEU N O   1 
ATOM   3049 C CB  . LEU B 2 148 ? 146.024 145.579 165.876 1.00 86.26  ? 110 LEU N CB  1 
ATOM   3050 C CG  . LEU B 2 148 ? 146.346 146.348 164.589 1.00 89.04  ? 110 LEU N CG  1 
ATOM   3051 C CD1 . LEU B 2 148 ? 147.728 146.984 164.675 1.00 85.90  ? 110 LEU N CD1 1 
ATOM   3052 C CD2 . LEU B 2 148 ? 146.223 145.479 163.347 1.00 86.94  ? 110 LEU N CD2 1 
ATOM   3053 N N   . ASP B 2 149 ? 147.940 144.518 168.431 1.00 86.78  ? 111 ASP N N   1 
ATOM   3054 C CA  . ASP B 2 149 ? 148.042 144.441 169.878 1.00 87.52  ? 111 ASP N CA  1 
ATOM   3055 C C   . ASP B 2 149 ? 147.635 145.768 170.510 1.00 88.32  ? 111 ASP N C   1 
ATOM   3056 O O   . ASP B 2 149 ? 147.643 146.821 169.868 1.00 90.40  ? 111 ASP N O   1 
ATOM   3057 C CB  . ASP B 2 149 ? 149.467 144.070 170.293 1.00 90.05  ? 111 ASP N CB  1 
ATOM   3058 C CG  . ASP B 2 149 ? 149.535 143.471 171.683 1.00 92.68  ? 111 ASP N CG  1 
ATOM   3059 O OD1 . ASP B 2 149 ? 148.673 143.807 172.520 1.00 96.60  ? 111 ASP N OD1 1 
ATOM   3060 O OD2 . ASP B 2 149 ? 150.452 142.662 171.938 1.00 92.10  ? 111 ASP N OD2 1 
ATOM   3061 N N   . GLY B 2 150 ? 147.274 145.705 171.792 1.00 89.47  ? 112 GLY N N   1 
ATOM   3062 C CA  . GLY B 2 150 ? 146.863 146.890 172.517 1.00 91.57  ? 112 GLY N CA  1 
ATOM   3063 C C   . GLY B 2 150 ? 147.301 146.817 173.963 1.00 90.71  ? 112 GLY N C   1 
ATOM   3064 O O   . GLY B 2 150 ? 147.743 145.775 174.451 1.00 90.62  ? 112 GLY N O   1 
ATOM   3065 N N   . TRP B 2 151 ? 147.172 147.950 174.650 1.00 99.27  ? 113 TRP N N   1 
ATOM   3066 C CA  . TRP B 2 151 ? 147.560 148.039 176.049 1.00 99.83  ? 113 TRP N CA  1 
ATOM   3067 C C   . TRP B 2 151 ? 146.636 149.013 176.763 1.00 99.58  ? 113 TRP N C   1 
ATOM   3068 O O   . TRP B 2 151 ? 145.992 149.860 176.141 1.00 99.39  ? 113 TRP N O   1 
ATOM   3069 C CB  . TRP B 2 151 ? 149.020 148.477 176.207 1.00 101.79 ? 113 TRP N CB  1 
ATOM   3070 C CG  . TRP B 2 151 ? 150.007 147.376 175.970 1.00 101.65 ? 113 TRP N CG  1 
ATOM   3071 C CD1 . TRP B 2 151 ? 150.546 147.003 174.774 1.00 101.49 ? 113 TRP N CD1 1 
ATOM   3072 C CD2 . TRP B 2 151 ? 150.572 146.504 176.955 1.00 101.30 ? 113 TRP N CD2 1 
ATOM   3073 N NE1 . TRP B 2 151 ? 151.411 145.952 174.953 1.00 101.38 ? 113 TRP N NE1 1 
ATOM   3074 C CE2 . TRP B 2 151 ? 151.445 145.627 176.284 1.00 100.56 ? 113 TRP N CE2 1 
ATOM   3075 C CE3 . TRP B 2 151 ? 150.424 146.380 178.339 1.00 102.25 ? 113 TRP N CE3 1 
ATOM   3076 C CZ2 . TRP B 2 151 ? 152.168 144.641 176.949 1.00 101.91 ? 113 TRP N CZ2 1 
ATOM   3077 C CZ3 . TRP B 2 151 ? 151.142 145.400 178.997 1.00 102.13 ? 113 TRP N CZ3 1 
ATOM   3078 C CH2 . TRP B 2 151 ? 152.002 144.544 178.302 1.00 103.69 ? 113 TRP N CH2 1 
ATOM   3079 N N   . GLY B 2 152 ? 146.579 148.878 178.087 1.00 109.45 ? 114 GLY N N   1 
ATOM   3080 C CA  . GLY B 2 152 ? 145.750 149.726 178.912 1.00 109.57 ? 114 GLY N CA  1 
ATOM   3081 C C   . GLY B 2 152 ? 146.552 150.801 179.630 1.00 109.16 ? 114 GLY N C   1 
ATOM   3082 O O   . GLY B 2 152 ? 147.779 150.820 179.614 1.00 111.46 ? 114 GLY N O   1 
ATOM   3083 N N   . GLN B 2 153 ? 145.817 151.712 180.270 1.00 124.55 ? 115 GLN N N   1 
ATOM   3084 C CA  . GLN B 2 153 ? 146.456 152.830 180.959 1.00 127.40 ? 115 GLN N CA  1 
ATOM   3085 C C   . GLN B 2 153 ? 147.206 152.361 182.200 1.00 126.26 ? 115 GLN N C   1 
ATOM   3086 O O   . GLN B 2 153 ? 148.356 152.752 182.427 1.00 126.41 ? 115 GLN N O   1 
ATOM   3087 C CB  . GLN B 2 153 ? 145.411 153.883 181.325 1.00 127.62 ? 115 GLN N CB  1 
ATOM   3088 C CG  . GLN B 2 153 ? 144.899 154.685 180.140 1.00 127.31 ? 115 GLN N CG  1 
ATOM   3089 C CD  . GLN B 2 153 ? 144.002 155.832 180.559 1.00 127.51 ? 115 GLN N CD  1 
ATOM   3090 O OE1 . GLN B 2 153 ? 143.612 155.937 181.721 1.00 128.00 ? 115 GLN N OE1 1 
ATOM   3091 N NE2 . GLN B 2 153 ? 143.671 156.701 179.611 1.00 127.20 ? 115 GLN N NE2 1 
ATOM   3092 N N   . GLY B 2 154 ? 146.573 151.522 183.015 1.00 129.46 ? 116 GLY N N   1 
ATOM   3093 C CA  . GLY B 2 154 ? 147.211 151.027 184.219 1.00 131.38 ? 116 GLY N CA  1 
ATOM   3094 C C   . GLY B 2 154 ? 146.374 151.185 185.471 1.00 132.60 ? 116 GLY N C   1 
ATOM   3095 O O   . GLY B 2 154 ? 145.605 152.143 185.599 1.00 132.42 ? 116 GLY N O   1 
ATOM   3096 N N   . THR B 2 155 ? 146.516 150.245 186.403 1.00 140.14 ? 117 THR N N   1 
ATOM   3097 C CA  . THR B 2 155 ? 145.816 150.278 187.680 1.00 140.13 ? 117 THR N CA  1 
ATOM   3098 C C   . THR B 2 155 ? 146.801 149.947 188.790 1.00 140.18 ? 117 THR N C   1 
ATOM   3099 O O   . THR B 2 155 ? 147.555 148.975 188.684 1.00 139.89 ? 117 THR N O   1 
ATOM   3100 C CB  . THR B 2 155 ? 144.643 149.289 187.699 1.00 140.34 ? 117 THR N CB  1 
ATOM   3101 O OG1 . THR B 2 155 ? 143.623 149.737 186.799 1.00 139.13 ? 117 THR N OG1 1 
ATOM   3102 C CG2 . THR B 2 155 ? 144.057 149.173 189.096 1.00 141.15 ? 117 THR N CG2 1 
ATOM   3103 N N   . GLN B 2 156 ? 146.790 150.751 189.850 1.00 154.03 ? 118 GLN N N   1 
ATOM   3104 C CA  . GLN B 2 156 ? 147.684 150.569 190.985 1.00 154.79 ? 118 GLN N CA  1 
ATOM   3105 C C   . GLN B 2 156 ? 146.916 149.959 192.151 1.00 155.80 ? 118 GLN N C   1 
ATOM   3106 O O   . GLN B 2 156 ? 145.869 150.478 192.550 1.00 155.10 ? 118 GLN N O   1 
ATOM   3107 C CB  . GLN B 2 156 ? 148.310 151.900 191.402 1.00 155.42 ? 118 GLN N CB  1 
ATOM   3108 C CG  . GLN B 2 156 ? 148.857 151.916 192.820 1.00 155.64 ? 118 GLN N CG  1 
ATOM   3109 C CD  . GLN B 2 156 ? 150.108 151.075 192.971 1.00 155.49 ? 118 GLN N CD  1 
ATOM   3110 O OE1 . GLN B 2 156 ? 150.036 149.873 193.223 1.00 156.06 ? 118 GLN N OE1 1 
ATOM   3111 N NE2 . GLN B 2 156 ? 151.267 151.706 192.821 1.00 155.65 ? 118 GLN N NE2 1 
ATOM   3112 N N   . VAL B 2 157 ? 147.438 148.861 192.691 1.00 161.03 ? 119 VAL N N   1 
ATOM   3113 C CA  . VAL B 2 157 ? 146.835 148.166 193.823 1.00 160.75 ? 119 VAL N CA  1 
ATOM   3114 C C   . VAL B 2 157 ? 147.834 148.187 194.970 1.00 160.65 ? 119 VAL N C   1 
ATOM   3115 O O   . VAL B 2 157 ? 148.980 147.749 194.811 1.00 159.87 ? 119 VAL N O   1 
ATOM   3116 C CB  . VAL B 2 157 ? 146.439 146.725 193.463 1.00 159.53 ? 119 VAL N CB  1 
ATOM   3117 C CG1 . VAL B 2 157 ? 146.021 145.960 194.710 1.00 159.80 ? 119 VAL N CG1 1 
ATOM   3118 C CG2 . VAL B 2 157 ? 145.323 146.725 192.430 1.00 159.32 ? 119 VAL N CG2 1 
ATOM   3119 N N   . THR B 2 158 ? 147.400 148.690 196.124 1.00 171.89 ? 120 THR N N   1 
ATOM   3120 C CA  . THR B 2 158 ? 148.257 148.846 197.290 1.00 171.43 ? 120 THR N CA  1 
ATOM   3121 C C   . THR B 2 158 ? 147.699 148.048 198.459 1.00 171.05 ? 120 THR N C   1 
ATOM   3122 O O   . THR B 2 158 ? 146.485 148.020 198.683 1.00 170.87 ? 120 THR N O   1 
ATOM   3123 C CB  . THR B 2 158 ? 148.390 150.321 197.689 1.00 171.06 ? 120 THR N CB  1 
ATOM   3124 O OG1 . THR B 2 158 ? 147.107 150.832 198.071 1.00 172.35 ? 120 THR N OG1 1 
ATOM   3125 C CG2 . THR B 2 158 ? 148.932 151.142 196.528 1.00 170.25 ? 120 THR N CG2 1 
ATOM   3126 N N   . VAL B 2 159 ? 148.594 147.402 199.202 1.00 177.18 ? 121 VAL N N   1 
ATOM   3127 C CA  . VAL B 2 159 ? 148.233 146.616 200.376 1.00 177.92 ? 121 VAL N CA  1 
ATOM   3128 C C   . VAL B 2 159 ? 148.639 147.392 201.620 1.00 178.52 ? 121 VAL N C   1 
ATOM   3129 O O   . VAL B 2 159 ? 149.771 147.886 201.711 1.00 178.77 ? 121 VAL N O   1 
ATOM   3130 C CB  . VAL B 2 159 ? 148.902 145.231 200.348 1.00 176.91 ? 121 VAL N CB  1 
ATOM   3131 N N   . SER B 2 160 ? 147.717 147.507 202.572 1.00 180.22 ? 122 SER N N   1 
ATOM   3132 C CA  . SER B 2 160 ? 147.988 148.252 203.794 1.00 179.43 ? 122 SER N CA  1 
ATOM   3133 C C   . SER B 2 160 ? 149.081 147.573 204.611 1.00 179.47 ? 122 SER N C   1 
ATOM   3134 O O   . SER B 2 160 ? 149.148 146.343 204.691 1.00 179.48 ? 122 SER N O   1 
ATOM   3135 C CB  . SER B 2 160 ? 146.715 148.383 204.629 1.00 178.28 ? 122 SER N CB  1 
ATOM   3136 N N   . SER B 2 161 ? 149.938 148.385 205.221 1.00 181.64 ? 123 SER N N   1 
ATOM   3137 C CA  . SER B 2 161 ? 151.036 147.875 206.034 1.00 181.37 ? 123 SER N CA  1 
ATOM   3138 C C   . SER B 2 161 ? 151.500 148.920 207.044 1.00 181.43 ? 123 SER N C   1 
ATOM   3139 O O   . SER B 2 161 ? 150.816 149.190 208.032 1.00 181.16 ? 123 SER N O   1 
ATOM   3140 C CB  . SER B 2 161 ? 152.206 147.444 205.147 1.00 180.69 ? 123 SER N CB  1 
HETATM 3141 C C1  . CLR C 3 .   ? 132.857 137.874 149.829 1.00 68.43  ? 401 CLR R C1  1 
HETATM 3142 C C2  . CLR C 3 .   ? 133.194 138.279 151.259 1.00 71.04  ? 401 CLR R C2  1 
HETATM 3143 C C3  . CLR C 3 .   ? 132.299 139.408 151.728 1.00 71.11  ? 401 CLR R C3  1 
HETATM 3144 C C4  . CLR C 3 .   ? 130.836 138.998 151.593 1.00 69.57  ? 401 CLR R C4  1 
HETATM 3145 C C5  . CLR C 3 .   ? 130.503 138.531 150.201 1.00 73.87  ? 401 CLR R C5  1 
HETATM 3146 C C6  . CLR C 3 .   ? 129.557 139.154 149.500 1.00 69.50  ? 401 CLR R C6  1 
HETATM 3147 C C7  . CLR C 3 .   ? 129.108 138.746 148.139 1.00 70.67  ? 401 CLR R C7  1 
HETATM 3148 C C8  . CLR C 3 .   ? 129.641 137.371 147.755 1.00 70.70  ? 401 CLR R C8  1 
HETATM 3149 C C9  . CLR C 3 .   ? 131.135 137.269 148.098 1.00 67.95  ? 401 CLR R C9  1 
HETATM 3150 C C10 . CLR C 3 .   ? 131.392 137.442 149.618 1.00 71.50  ? 401 CLR R C10 1 
HETATM 3151 C C11 . CLR C 3 .   ? 131.764 135.995 147.517 1.00 65.13  ? 401 CLR R C11 1 
HETATM 3152 C C12 . CLR C 3 .   ? 131.407 135.703 146.054 1.00 65.10  ? 401 CLR R C12 1 
HETATM 3153 C C13 . CLR C 3 .   ? 129.893 135.715 145.827 1.00 64.63  ? 401 CLR R C13 1 
HETATM 3154 C C14 . CLR C 3 .   ? 129.424 137.104 146.277 1.00 66.31  ? 401 CLR R C14 1 
HETATM 3155 C C15 . CLR C 3 .   ? 128.015 137.230 145.724 1.00 67.03  ? 401 CLR R C15 1 
HETATM 3156 C C16 . CLR C 3 .   ? 128.118 136.548 144.350 1.00 66.88  ? 401 CLR R C16 1 
HETATM 3157 C C17 . CLR C 3 .   ? 129.397 135.666 144.356 1.00 67.84  ? 401 CLR R C17 1 
HETATM 3158 C C18 . CLR C 3 .   ? 129.210 134.614 146.637 1.00 67.40  ? 401 CLR R C18 1 
HETATM 3159 C C19 . CLR C 3 .   ? 131.132 136.137 150.386 1.00 67.12  ? 401 CLR R C19 1 
HETATM 3160 C C20 . CLR C 3 .   ? 129.161 134.291 143.707 1.00 65.59  ? 401 CLR R C20 1 
HETATM 3161 C C21 . CLR C 3 .   ? 130.390 133.752 142.982 1.00 63.48  ? 401 CLR R C21 1 
HETATM 3162 C C22 . CLR C 3 .   ? 127.955 134.331 142.756 1.00 60.76  ? 401 CLR R C22 1 
HETATM 3163 C C23 . CLR C 3 .   ? 127.558 132.990 142.150 1.00 65.35  ? 401 CLR R C23 1 
HETATM 3164 C C24 . CLR C 3 .   ? 126.101 132.972 141.701 1.00 73.27  ? 401 CLR R C24 1 
HETATM 3165 C C25 . CLR C 3 .   ? 125.597 131.635 141.153 1.00 68.97  ? 401 CLR R C25 1 
HETATM 3166 C C26 . CLR C 3 .   ? 125.816 130.522 142.173 1.00 64.12  ? 401 CLR R C26 1 
HETATM 3167 C C27 . CLR C 3 .   ? 124.126 131.694 140.755 1.00 67.19  ? 401 CLR R C27 1 
HETATM 3168 O O1  . CLR C 3 .   ? 132.633 139.720 153.064 1.00 65.39  ? 401 CLR R O1  1 
HETATM 3169 C C10 . VH6 D 4 .   ? 116.374 137.917 121.502 1.00 60.43  ? 402 VH6 R C10 1 
HETATM 3170 C C13 . VH6 D 4 .   ? 112.768 137.071 122.054 1.00 60.67  ? 402 VH6 R C13 1 
HETATM 3171 C C15 . VH6 D 4 .   ? 118.008 136.199 122.501 1.00 53.91  ? 402 VH6 R C15 1 
HETATM 3172 C C17 . VH6 D 4 .   ? 119.731 137.944 122.019 1.00 61.05  ? 402 VH6 R C17 1 
HETATM 3173 C C20 . VH6 D 4 .   ? 121.787 136.192 122.503 1.00 55.02  ? 402 VH6 R C20 1 
HETATM 3174 C C21 . VH6 D 4 .   ? 120.482 135.770 122.614 1.00 58.39  ? 402 VH6 R C21 1 
HETATM 3175 C C22 . VH6 D 4 .   ? 123.504 137.961 122.014 1.00 60.82  ? 402 VH6 R C22 1 
HETATM 3176 C C24 . VH6 D 4 .   ? 123.446 139.522 120.116 1.00 61.68  ? 402 VH6 R C24 1 
HETATM 3177 C C26 . VH6 D 4 .   ? 125.242 140.975 119.034 1.00 56.59  ? 402 VH6 R C26 1 
HETATM 3178 C C28 . VH6 D 4 .   ? 127.618 140.741 119.495 1.00 51.92  ? 402 VH6 R C28 1 
HETATM 3179 C C02 . VH6 D 4 .   ? 112.844 133.599 121.239 1.00 52.76  ? 402 VH6 R C02 1 
HETATM 3180 C C03 . VH6 D 4 .   ? 114.144 133.449 120.514 1.00 56.53  ? 402 VH6 R C03 1 
HETATM 3181 C C05 . VH6 D 4 .   ? 116.451 132.919 121.032 1.00 62.90  ? 402 VH6 R C05 1 
HETATM 3182 C C06 . VH6 D 4 .   ? 117.265 133.604 119.973 1.00 58.92  ? 402 VH6 R C06 1 
HETATM 3183 C C07 . VH6 D 4 .   ? 118.036 134.769 120.523 1.00 57.15  ? 402 VH6 R C07 1 
HETATM 3184 C C09 . VH6 D 4 .   ? 116.619 136.738 120.619 1.00 58.92  ? 402 VH6 R C09 1 
HETATM 3185 C C12 . VH6 D 4 .   ? 114.182 136.890 121.583 1.00 55.38  ? 402 VH6 R C12 1 
HETATM 3186 C C14 . VH6 D 4 .   ? 112.034 135.766 121.986 1.00 56.14  ? 402 VH6 R C14 1 
HETATM 3187 C C16 . VH6 D 4 .   ? 119.438 136.636 122.349 1.00 58.56  ? 402 VH6 R C16 1 
HETATM 3188 C C18 . VH6 D 4 .   ? 121.032 138.367 121.912 1.00 58.52  ? 402 VH6 R C18 1 
HETATM 3189 C C19 . VH6 D 4 .   ? 122.079 137.495 122.143 1.00 57.69  ? 402 VH6 R C19 1 
HETATM 3190 C C25 . VH6 D 4 .   ? 124.109 139.990 118.841 1.00 60.66  ? 402 VH6 R C25 1 
HETATM 3191 C C29 . VH6 D 4 .   ? 128.546 139.708 120.042 1.00 58.16  ? 402 VH6 R C29 1 
HETATM 3192 C C31 . VH6 D 4 .   ? 128.958 137.305 119.937 1.00 57.40  ? 402 VH6 R C31 1 
HETATM 3193 C C32 . VH6 D 4 .   ? 128.318 135.944 119.944 1.00 58.02  ? 402 VH6 R C32 1 
HETATM 3194 C C33 . VH6 D 4 .   ? 126.927 135.957 120.523 1.00 61.05  ? 402 VH6 R C33 1 
HETATM 3195 C C35 . VH6 D 4 .   ? 124.543 135.925 119.964 1.00 59.83  ? 402 VH6 R C35 1 
HETATM 3196 C C36 . VH6 D 4 .   ? 123.669 137.129 119.728 1.00 59.87  ? 402 VH6 R C36 1 
HETATM 3197 N N01 . VH6 D 4 .   ? 112.969 134.669 122.225 1.00 52.03  ? 402 VH6 R N01 1 
HETATM 3198 N N04 . VH6 D 4 .   ? 115.280 133.719 121.396 1.00 62.72  ? 402 VH6 R N04 1 
HETATM 3199 N N08 . VH6 D 4 .   ? 117.240 135.651 121.373 1.00 50.27  ? 402 VH6 R N08 1 
HETATM 3200 N N11 . VH6 D 4 .   ? 114.941 138.135 121.695 1.00 60.67  ? 402 VH6 R N11 1 
HETATM 3201 N N23 . VH6 D 4 .   ? 123.961 138.246 120.641 1.00 67.27  ? 402 VH6 R N23 1 
HETATM 3202 N N27 . VH6 D 4 .   ? 126.259 140.459 119.954 1.00 58.92  ? 402 VH6 R N27 1 
HETATM 3203 N N30 . VH6 D 4 .   ? 127.952 138.366 120.013 1.00 61.84  ? 402 VH6 R N30 1 
HETATM 3204 N N34 . VH6 D 4 .   ? 125.913 136.112 119.475 1.00 64.34  ? 402 VH6 R N34 1 
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