data_8ZPM
# 
_entry.id   8ZPM 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZPM         pdb_00008zpm 10.2210/pdb8zpm/pdb 
WWPDB D_1300048277 ?            ?                   
EMDB  EMD-60349    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-26 ? 
2 'EM metadata'     1 0 2025-02-26 ? 
3 'Additional map'  1 0 2025-02-26 1 
4 FSC               1 0 2025-02-26 ? 
5 'Half map'        1 0 2025-02-26 1 
6 'Half map'        1 0 2025-02-26 2 
7 Image             1 0 2025-02-26 ? 
8 'Primary map'     1 0 2025-02-26 ? 
9 'Structure model' 1 1 2025-04-02 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Additional map'  repository 'Initial release' ? ? 
4 4 FSC               repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 'Half map'        repository 'Initial release' ? ? 
7 7 Image             repository 'Initial release' ? ? 
8 8 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 9 'Structure model' 'Data collection'     
2 9 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 9 'Structure model' citation        
2 9 'Structure model' citation_author 
3 9 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  9 'Structure model' '_citation.country'                 
2  9 'Structure model' '_citation.journal_abbrev'          
3  9 'Structure model' '_citation.journal_id_ASTM'         
4  9 'Structure model' '_citation.journal_id_CSD'          
5  9 'Structure model' '_citation.journal_id_ISSN'         
6  9 'Structure model' '_citation.journal_volume'          
7  9 'Structure model' '_citation.page_first'              
8  9 'Structure model' '_citation.page_last'               
9  9 'Structure model' '_citation.pdbx_database_id_DOI'    
10 9 'Structure model' '_citation.pdbx_database_id_PubMed' 
11 9 'Structure model' '_citation.title'                   
12 9 'Structure model' '_citation.year'                    
13 9 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZPM 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-30 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM strucutre of CXCR4 complexed with antagonist AMD070' 
_pdbx_database_related.db_id          EMD-60349 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              honglihu@cuhk.edu.cn 
_pdbx_contact_author.name_first         Hongli 
_pdbx_contact_author.name_last          Hu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3658-272X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Jiao, H.Z.' 1 ? 
'Hu, H.L.'   2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Proc.Natl.Acad.Sci.USA 
_citation.journal_id_ASTM           PNASA6 
_citation.journal_id_CSD            0040 
_citation.journal_id_ISSN           1091-6490 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            122 
_citation.language                  ? 
_citation.page_first                e2425795122 
_citation.page_last                 e2425795122 
_citation.title                     
'Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1073/pnas.2425795122 
_citation.pdbx_database_id_PubMed   40063796 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sang, X.'  1  0009-0002-6561-2254 
primary 'Jiao, H.'  2  ?                   
primary 'Meng, Q.'  3  ?                   
primary 'Fang, X.'  4  ?                   
primary 'Pan, Q.'   5  ?                   
primary 'Zhou, J.'  6  ?                   
primary 'Qian, T.'  7  ?                   
primary 'Zhang, W.' 8  ?                   
primary 'Xu, Y.'    9  ?                   
primary 'An, J.'    10 ?                   
primary 'Huang, Z.' 11 ?                   
primary 'Hu, H.'    12 0000-0003-3658-272X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Soluble cytochrome b562,C-X-C chemokine receptor type 4'                                          55451.062 1 ? 
? ? ? 
2 polymer     man 'Nb6 nanobody'                                                                                     18665.906 1 ? 
? ? ? 
3 non-polymer syn '(S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine' 349.473   1 ? 
? ? ? 
4 non-polymer syn CHOLESTEROL                                                                                        386.654   2 ? 
? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;Cytochrome b-562,CXC-R4,CXCR-4,FB22,Fusin,HM89,LCR1,Leukocyte-derived seven transmembrane domain receptor,LESTR,Lipopolysaccharide-associated protein 3,LAP-3,LPS-associated protein 3,NPYRL,Stromal cell-derived factor 1 receptor,SDF-1 receptor
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MKTIIALSYIFCLVFADYKDDDDKGSADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPD
SPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLLVPRGSMEGISIYTSDNYTEEMGSGDYD
SMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANW
YFGNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD
RYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISRLKSVRLLSGSREKDRNLRRITRPTVILILAFFACWLP
YYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSGRPLEVLFQGPHHHH
HHHHHH
;
;MKTIIALSYIFCLVFADYKDDDDKGSADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPD
SPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLLVPRGSMEGISIYTSDNYTEEMGSGDYD
SMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANW
YFGNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD
RYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISRLKSVRLLSGSREKDRNLRRITRPTVILILAFFACWLP
YYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSGRPLEVLFQGPHHHH
HHHHHH
;
R ? 
2 'polypeptide(L)' no no 
;MLLVNQSHQGFNKEHTSKMVSAIVLYVLLAAAAHSAFAMAQVQLQESGGGLVQAGESLRLSCAASGTIFRLYDMGWYRRV
SGNQRELVASITSGGSTKYGDSVKGRFTISRDNAKNTVYLQMSSLKPEDTAVYYCNAEYRTGIWEELLDGWGQGTQVTVS
SHHHHHHHH
;
;MLLVNQSHQGFNKEHTSKMVSAIVLYVLLAAAAHSAFAMAQVQLQESGGGLVQAGESLRLSCAASGTIFRLYDMGWYRRV
SGNQRELVASITSGGSTKYGDSVKGRFTISRDNAKNTVYLQMSSLKPEDTAVYYCNAEYRTGIWEELLDGWGQGTQVTVS
SHHHHHHHH
;
N ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 '(S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine' A1D8L 
4 CHOLESTEROL                                                                                        CLR   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LYS n 
1 3   THR n 
1 4   ILE n 
1 5   ILE n 
1 6   ALA n 
1 7   LEU n 
1 8   SER n 
1 9   TYR n 
1 10  ILE n 
1 11  PHE n 
1 12  CYS n 
1 13  LEU n 
1 14  VAL n 
1 15  PHE n 
1 16  ALA n 
1 17  ASP n 
1 18  TYR n 
1 19  LYS n 
1 20  ASP n 
1 21  ASP n 
1 22  ASP n 
1 23  ASP n 
1 24  LYS n 
1 25  GLY n 
1 26  SER n 
1 27  ALA n 
1 28  ASP n 
1 29  LEU n 
1 30  GLU n 
1 31  ASP n 
1 32  ASN n 
1 33  TRP n 
1 34  GLU n 
1 35  THR n 
1 36  LEU n 
1 37  ASN n 
1 38  ASP n 
1 39  ASN n 
1 40  LEU n 
1 41  LYS n 
1 42  VAL n 
1 43  ILE n 
1 44  GLU n 
1 45  LYS n 
1 46  ALA n 
1 47  ASP n 
1 48  ASN n 
1 49  ALA n 
1 50  ALA n 
1 51  GLN n 
1 52  VAL n 
1 53  LYS n 
1 54  ASP n 
1 55  ALA n 
1 56  LEU n 
1 57  THR n 
1 58  LYS n 
1 59  MET n 
1 60  ARG n 
1 61  ALA n 
1 62  ALA n 
1 63  ALA n 
1 64  LEU n 
1 65  ASP n 
1 66  ALA n 
1 67  GLN n 
1 68  LYS n 
1 69  ALA n 
1 70  THR n 
1 71  PRO n 
1 72  PRO n 
1 73  LYS n 
1 74  LEU n 
1 75  GLU n 
1 76  ASP n 
1 77  LYS n 
1 78  SER n 
1 79  PRO n 
1 80  ASP n 
1 81  SER n 
1 82  PRO n 
1 83  GLU n 
1 84  MET n 
1 85  LYS n 
1 86  ASP n 
1 87  PHE n 
1 88  ARG n 
1 89  HIS n 
1 90  GLY n 
1 91  PHE n 
1 92  ASP n 
1 93  ILE n 
1 94  LEU n 
1 95  VAL n 
1 96  GLY n 
1 97  GLN n 
1 98  ILE n 
1 99  ASP n 
1 100 ASP n 
1 101 ALA n 
1 102 LEU n 
1 103 LYS n 
1 104 LEU n 
1 105 ALA n 
1 106 ASN n 
1 107 GLU n 
1 108 GLY n 
1 109 LYS n 
1 110 VAL n 
1 111 LYS n 
1 112 GLU n 
1 113 ALA n 
1 114 GLN n 
1 115 ALA n 
1 116 ALA n 
1 117 ALA n 
1 118 GLU n 
1 119 GLN n 
1 120 LEU n 
1 121 LYS n 
1 122 THR n 
1 123 THR n 
1 124 ARG n 
1 125 ASN n 
1 126 ALA n 
1 127 TYR n 
1 128 ILE n 
1 129 GLN n 
1 130 LYS n 
1 131 TYR n 
1 132 LEU n 
1 133 LEU n 
1 134 VAL n 
1 135 PRO n 
1 136 ARG n 
1 137 GLY n 
1 138 SER n 
1 139 MET n 
1 140 GLU n 
1 141 GLY n 
1 142 ILE n 
1 143 SER n 
1 144 ILE n 
1 145 TYR n 
1 146 THR n 
1 147 SER n 
1 148 ASP n 
1 149 ASN n 
1 150 TYR n 
1 151 THR n 
1 152 GLU n 
1 153 GLU n 
1 154 MET n 
1 155 GLY n 
1 156 SER n 
1 157 GLY n 
1 158 ASP n 
1 159 TYR n 
1 160 ASP n 
1 161 SER n 
1 162 MET n 
1 163 LYS n 
1 164 GLU n 
1 165 PRO n 
1 166 CYS n 
1 167 PHE n 
1 168 ARG n 
1 169 GLU n 
1 170 GLU n 
1 171 ASN n 
1 172 ALA n 
1 173 ASN n 
1 174 PHE n 
1 175 ASN n 
1 176 LYS n 
1 177 ILE n 
1 178 PHE n 
1 179 LEU n 
1 180 PRO n 
1 181 THR n 
1 182 ILE n 
1 183 TYR n 
1 184 SER n 
1 185 ILE n 
1 186 ILE n 
1 187 PHE n 
1 188 LEU n 
1 189 THR n 
1 190 GLY n 
1 191 ILE n 
1 192 VAL n 
1 193 GLY n 
1 194 ASN n 
1 195 GLY n 
1 196 LEU n 
1 197 VAL n 
1 198 ILE n 
1 199 LEU n 
1 200 VAL n 
1 201 MET n 
1 202 GLY n 
1 203 TYR n 
1 204 GLN n 
1 205 LYS n 
1 206 LYS n 
1 207 LEU n 
1 208 ARG n 
1 209 SER n 
1 210 MET n 
1 211 THR n 
1 212 ASP n 
1 213 LYS n 
1 214 TYR n 
1 215 ARG n 
1 216 LEU n 
1 217 HIS n 
1 218 LEU n 
1 219 SER n 
1 220 VAL n 
1 221 ALA n 
1 222 ASP n 
1 223 LEU n 
1 224 LEU n 
1 225 PHE n 
1 226 VAL n 
1 227 ILE n 
1 228 THR n 
1 229 LEU n 
1 230 PRO n 
1 231 PHE n 
1 232 TRP n 
1 233 ALA n 
1 234 VAL n 
1 235 ASP n 
1 236 ALA n 
1 237 VAL n 
1 238 ALA n 
1 239 ASN n 
1 240 TRP n 
1 241 TYR n 
1 242 PHE n 
1 243 GLY n 
1 244 ASN n 
1 245 PHE n 
1 246 LEU n 
1 247 CYS n 
1 248 LYS n 
1 249 ALA n 
1 250 VAL n 
1 251 HIS n 
1 252 VAL n 
1 253 ILE n 
1 254 TYR n 
1 255 THR n 
1 256 VAL n 
1 257 ASN n 
1 258 LEU n 
1 259 TYR n 
1 260 SER n 
1 261 SER n 
1 262 VAL n 
1 263 TRP n 
1 264 ILE n 
1 265 LEU n 
1 266 ALA n 
1 267 PHE n 
1 268 ILE n 
1 269 SER n 
1 270 LEU n 
1 271 ASP n 
1 272 ARG n 
1 273 TYR n 
1 274 LEU n 
1 275 ALA n 
1 276 ILE n 
1 277 VAL n 
1 278 HIS n 
1 279 ALA n 
1 280 THR n 
1 281 ASN n 
1 282 SER n 
1 283 GLN n 
1 284 ARG n 
1 285 PRO n 
1 286 ARG n 
1 287 LYS n 
1 288 LEU n 
1 289 LEU n 
1 290 ALA n 
1 291 GLU n 
1 292 LYS n 
1 293 VAL n 
1 294 VAL n 
1 295 TYR n 
1 296 VAL n 
1 297 GLY n 
1 298 VAL n 
1 299 TRP n 
1 300 ILE n 
1 301 PRO n 
1 302 ALA n 
1 303 LEU n 
1 304 LEU n 
1 305 LEU n 
1 306 THR n 
1 307 ILE n 
1 308 PRO n 
1 309 ASP n 
1 310 PHE n 
1 311 ILE n 
1 312 PHE n 
1 313 ALA n 
1 314 ASN n 
1 315 VAL n 
1 316 SER n 
1 317 GLU n 
1 318 ALA n 
1 319 ASP n 
1 320 ASP n 
1 321 ARG n 
1 322 TYR n 
1 323 ILE n 
1 324 CYS n 
1 325 ASP n 
1 326 ARG n 
1 327 PHE n 
1 328 TYR n 
1 329 PRO n 
1 330 ASN n 
1 331 ASP n 
1 332 LEU n 
1 333 TRP n 
1 334 VAL n 
1 335 VAL n 
1 336 VAL n 
1 337 PHE n 
1 338 GLN n 
1 339 PHE n 
1 340 GLN n 
1 341 HIS n 
1 342 ILE n 
1 343 MET n 
1 344 VAL n 
1 345 GLY n 
1 346 LEU n 
1 347 ILE n 
1 348 LEU n 
1 349 PRO n 
1 350 GLY n 
1 351 ILE n 
1 352 VAL n 
1 353 ILE n 
1 354 LEU n 
1 355 SER n 
1 356 CYS n 
1 357 TYR n 
1 358 CYS n 
1 359 ILE n 
1 360 ILE n 
1 361 ILE n 
1 362 SER n 
1 363 ARG n 
1 364 LEU n 
1 365 LYS n 
1 366 SER n 
1 367 VAL n 
1 368 ARG n 
1 369 LEU n 
1 370 LEU n 
1 371 SER n 
1 372 GLY n 
1 373 SER n 
1 374 ARG n 
1 375 GLU n 
1 376 LYS n 
1 377 ASP n 
1 378 ARG n 
1 379 ASN n 
1 380 LEU n 
1 381 ARG n 
1 382 ARG n 
1 383 ILE n 
1 384 THR n 
1 385 ARG n 
1 386 PRO n 
1 387 THR n 
1 388 VAL n 
1 389 ILE n 
1 390 LEU n 
1 391 ILE n 
1 392 LEU n 
1 393 ALA n 
1 394 PHE n 
1 395 PHE n 
1 396 ALA n 
1 397 CYS n 
1 398 TRP n 
1 399 LEU n 
1 400 PRO n 
1 401 TYR n 
1 402 TYR n 
1 403 ILE n 
1 404 GLY n 
1 405 ILE n 
1 406 SER n 
1 407 ILE n 
1 408 ASP n 
1 409 SER n 
1 410 PHE n 
1 411 ILE n 
1 412 LEU n 
1 413 LEU n 
1 414 GLU n 
1 415 ILE n 
1 416 ILE n 
1 417 LYS n 
1 418 GLN n 
1 419 GLY n 
1 420 CYS n 
1 421 GLU n 
1 422 PHE n 
1 423 GLU n 
1 424 ASN n 
1 425 THR n 
1 426 VAL n 
1 427 HIS n 
1 428 LYS n 
1 429 TRP n 
1 430 ILE n 
1 431 SER n 
1 432 ILE n 
1 433 THR n 
1 434 GLU n 
1 435 ALA n 
1 436 LEU n 
1 437 ALA n 
1 438 PHE n 
1 439 PHE n 
1 440 HIS n 
1 441 CYS n 
1 442 CYS n 
1 443 LEU n 
1 444 ASN n 
1 445 PRO n 
1 446 ILE n 
1 447 LEU n 
1 448 TYR n 
1 449 ALA n 
1 450 PHE n 
1 451 LEU n 
1 452 GLY n 
1 453 ALA n 
1 454 LYS n 
1 455 PHE n 
1 456 LYS n 
1 457 THR n 
1 458 SER n 
1 459 ALA n 
1 460 GLN n 
1 461 HIS n 
1 462 ALA n 
1 463 LEU n 
1 464 THR n 
1 465 SER n 
1 466 GLY n 
1 467 ARG n 
1 468 PRO n 
1 469 LEU n 
1 470 GLU n 
1 471 VAL n 
1 472 LEU n 
1 473 PHE n 
1 474 GLN n 
1 475 GLY n 
1 476 PRO n 
1 477 HIS n 
1 478 HIS n 
1 479 HIS n 
1 480 HIS n 
1 481 HIS n 
1 482 HIS n 
1 483 HIS n 
1 484 HIS n 
1 485 HIS n 
1 486 HIS n 
2 1   MET n 
2 2   LEU n 
2 3   LEU n 
2 4   VAL n 
2 5   ASN n 
2 6   GLN n 
2 7   SER n 
2 8   HIS n 
2 9   GLN n 
2 10  GLY n 
2 11  PHE n 
2 12  ASN n 
2 13  LYS n 
2 14  GLU n 
2 15  HIS n 
2 16  THR n 
2 17  SER n 
2 18  LYS n 
2 19  MET n 
2 20  VAL n 
2 21  SER n 
2 22  ALA n 
2 23  ILE n 
2 24  VAL n 
2 25  LEU n 
2 26  TYR n 
2 27  VAL n 
2 28  LEU n 
2 29  LEU n 
2 30  ALA n 
2 31  ALA n 
2 32  ALA n 
2 33  ALA n 
2 34  HIS n 
2 35  SER n 
2 36  ALA n 
2 37  PHE n 
2 38  ALA n 
2 39  MET n 
2 40  ALA n 
2 41  GLN n 
2 42  VAL n 
2 43  GLN n 
2 44  LEU n 
2 45  GLN n 
2 46  GLU n 
2 47  SER n 
2 48  GLY n 
2 49  GLY n 
2 50  GLY n 
2 51  LEU n 
2 52  VAL n 
2 53  GLN n 
2 54  ALA n 
2 55  GLY n 
2 56  GLU n 
2 57  SER n 
2 58  LEU n 
2 59  ARG n 
2 60  LEU n 
2 61  SER n 
2 62  CYS n 
2 63  ALA n 
2 64  ALA n 
2 65  SER n 
2 66  GLY n 
2 67  THR n 
2 68  ILE n 
2 69  PHE n 
2 70  ARG n 
2 71  LEU n 
2 72  TYR n 
2 73  ASP n 
2 74  MET n 
2 75  GLY n 
2 76  TRP n 
2 77  TYR n 
2 78  ARG n 
2 79  ARG n 
2 80  VAL n 
2 81  SER n 
2 82  GLY n 
2 83  ASN n 
2 84  GLN n 
2 85  ARG n 
2 86  GLU n 
2 87  LEU n 
2 88  VAL n 
2 89  ALA n 
2 90  SER n 
2 91  ILE n 
2 92  THR n 
2 93  SER n 
2 94  GLY n 
2 95  GLY n 
2 96  SER n 
2 97  THR n 
2 98  LYS n 
2 99  TYR n 
2 100 GLY n 
2 101 ASP n 
2 102 SER n 
2 103 VAL n 
2 104 LYS n 
2 105 GLY n 
2 106 ARG n 
2 107 PHE n 
2 108 THR n 
2 109 ILE n 
2 110 SER n 
2 111 ARG n 
2 112 ASP n 
2 113 ASN n 
2 114 ALA n 
2 115 LYS n 
2 116 ASN n 
2 117 THR n 
2 118 VAL n 
2 119 TYR n 
2 120 LEU n 
2 121 GLN n 
2 122 MET n 
2 123 SER n 
2 124 SER n 
2 125 LEU n 
2 126 LYS n 
2 127 PRO n 
2 128 GLU n 
2 129 ASP n 
2 130 THR n 
2 131 ALA n 
2 132 VAL n 
2 133 TYR n 
2 134 TYR n 
2 135 CYS n 
2 136 ASN n 
2 137 ALA n 
2 138 GLU n 
2 139 TYR n 
2 140 ARG n 
2 141 THR n 
2 142 GLY n 
2 143 ILE n 
2 144 TRP n 
2 145 GLU n 
2 146 GLU n 
2 147 LEU n 
2 148 LEU n 
2 149 ASP n 
2 150 GLY n 
2 151 TRP n 
2 152 GLY n 
2 153 GLN n 
2 154 GLY n 
2 155 THR n 
2 156 GLN n 
2 157 VAL n 
2 158 THR n 
2 159 VAL n 
2 160 SER n 
2 161 SER n 
2 162 HIS n 
2 163 HIS n 
2 164 HIS n 
2 165 HIS n 
2 166 HIS n 
2 167 HIS n 
2 168 HIS n 
2 169 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   138 ?     ? cybC  ? ? ? ? ? ? 'Escherichia coli' 562  ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 
7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 2 sample 'Biological sequence' 139 386 human ? CXCR4 ? ? ? ? ? ? 'Homo sapiens'     9606 ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 
7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 3 sample 'Biological sequence' 387 486 human ? CXCR4 ? ? ? ? ? ? 'Homo sapiens'     9606 ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 
7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1   169 ?     ? ?     ? ? ? ? ? ? 'Lama glama'       9844 ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 
7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1D8L non-polymer         . '(S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine' 
AMD-070 'C21 H27 N5'     349.473 
ALA   'L-peptide linking' y ALANINE                                                                                            ? 
'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE                                                                                           ? 
'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE                                                                                         ? 
'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                                                                    ? 
'C4 H7 N O4'     133.103 
CLR   non-polymer         . CHOLESTEROL                                                                                        ? 
'C27 H46 O'      386.654 
CYS   'L-peptide linking' y CYSTEINE                                                                                           ? 
'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE                                                                                          ? 
'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                                                                    ? 
'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE                                                                                            ? 
'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE                                                                                          ? 
'C6 H10 N3 O2 1' 156.162 
ILE   'L-peptide linking' y ISOLEUCINE                                                                                         ? 
'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE                                                                                            ? 
'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE                                                                                             ? 
'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE                                                                                         ? 
'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE                                                                                      ? 
'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE                                                                                            ? 
'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE                                                                                             ? 
'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE                                                                                          ? 
'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                                                                         ? 
'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE                                                                                           ? 
'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE                                                                                             ? 
'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -137 ?   ?   ?   R . n 
A 1 2   LYS 2   -136 ?   ?   ?   R . n 
A 1 3   THR 3   -135 ?   ?   ?   R . n 
A 1 4   ILE 4   -134 ?   ?   ?   R . n 
A 1 5   ILE 5   -133 ?   ?   ?   R . n 
A 1 6   ALA 6   -132 ?   ?   ?   R . n 
A 1 7   LEU 7   -131 ?   ?   ?   R . n 
A 1 8   SER 8   -130 ?   ?   ?   R . n 
A 1 9   TYR 9   -129 ?   ?   ?   R . n 
A 1 10  ILE 10  -128 ?   ?   ?   R . n 
A 1 11  PHE 11  -127 ?   ?   ?   R . n 
A 1 12  CYS 12  -126 ?   ?   ?   R . n 
A 1 13  LEU 13  -125 ?   ?   ?   R . n 
A 1 14  VAL 14  -124 ?   ?   ?   R . n 
A 1 15  PHE 15  -123 ?   ?   ?   R . n 
A 1 16  ALA 16  -122 ?   ?   ?   R . n 
A 1 17  ASP 17  -121 ?   ?   ?   R . n 
A 1 18  TYR 18  -120 ?   ?   ?   R . n 
A 1 19  LYS 19  -119 ?   ?   ?   R . n 
A 1 20  ASP 20  -118 ?   ?   ?   R . n 
A 1 21  ASP 21  -117 ?   ?   ?   R . n 
A 1 22  ASP 22  -116 ?   ?   ?   R . n 
A 1 23  ASP 23  -115 ?   ?   ?   R . n 
A 1 24  LYS 24  -114 ?   ?   ?   R . n 
A 1 25  GLY 25  -113 ?   ?   ?   R . n 
A 1 26  SER 26  -112 ?   ?   ?   R . n 
A 1 27  ALA 27  -111 ?   ?   ?   R . n 
A 1 28  ASP 28  -110 ?   ?   ?   R . n 
A 1 29  LEU 29  -109 ?   ?   ?   R . n 
A 1 30  GLU 30  -108 ?   ?   ?   R . n 
A 1 31  ASP 31  -107 ?   ?   ?   R . n 
A 1 32  ASN 32  -106 ?   ?   ?   R . n 
A 1 33  TRP 33  -105 ?   ?   ?   R . n 
A 1 34  GLU 34  -104 ?   ?   ?   R . n 
A 1 35  THR 35  -103 ?   ?   ?   R . n 
A 1 36  LEU 36  -102 ?   ?   ?   R . n 
A 1 37  ASN 37  -101 ?   ?   ?   R . n 
A 1 38  ASP 38  -100 ?   ?   ?   R . n 
A 1 39  ASN 39  -99  ?   ?   ?   R . n 
A 1 40  LEU 40  -98  ?   ?   ?   R . n 
A 1 41  LYS 41  -97  ?   ?   ?   R . n 
A 1 42  VAL 42  -96  ?   ?   ?   R . n 
A 1 43  ILE 43  -95  ?   ?   ?   R . n 
A 1 44  GLU 44  -94  ?   ?   ?   R . n 
A 1 45  LYS 45  -93  ?   ?   ?   R . n 
A 1 46  ALA 46  -92  ?   ?   ?   R . n 
A 1 47  ASP 47  -91  ?   ?   ?   R . n 
A 1 48  ASN 48  -90  ?   ?   ?   R . n 
A 1 49  ALA 49  -89  ?   ?   ?   R . n 
A 1 50  ALA 50  -88  ?   ?   ?   R . n 
A 1 51  GLN 51  -87  ?   ?   ?   R . n 
A 1 52  VAL 52  -86  ?   ?   ?   R . n 
A 1 53  LYS 53  -85  ?   ?   ?   R . n 
A 1 54  ASP 54  -84  ?   ?   ?   R . n 
A 1 55  ALA 55  -83  ?   ?   ?   R . n 
A 1 56  LEU 56  -82  ?   ?   ?   R . n 
A 1 57  THR 57  -81  ?   ?   ?   R . n 
A 1 58  LYS 58  -80  ?   ?   ?   R . n 
A 1 59  MET 59  -79  ?   ?   ?   R . n 
A 1 60  ARG 60  -78  ?   ?   ?   R . n 
A 1 61  ALA 61  -77  ?   ?   ?   R . n 
A 1 62  ALA 62  -76  ?   ?   ?   R . n 
A 1 63  ALA 63  -75  ?   ?   ?   R . n 
A 1 64  LEU 64  -74  ?   ?   ?   R . n 
A 1 65  ASP 65  -73  ?   ?   ?   R . n 
A 1 66  ALA 66  -72  ?   ?   ?   R . n 
A 1 67  GLN 67  -71  ?   ?   ?   R . n 
A 1 68  LYS 68  -70  ?   ?   ?   R . n 
A 1 69  ALA 69  -69  ?   ?   ?   R . n 
A 1 70  THR 70  -68  ?   ?   ?   R . n 
A 1 71  PRO 71  -67  ?   ?   ?   R . n 
A 1 72  PRO 72  -66  ?   ?   ?   R . n 
A 1 73  LYS 73  -65  ?   ?   ?   R . n 
A 1 74  LEU 74  -64  ?   ?   ?   R . n 
A 1 75  GLU 75  -63  ?   ?   ?   R . n 
A 1 76  ASP 76  -62  ?   ?   ?   R . n 
A 1 77  LYS 77  -61  ?   ?   ?   R . n 
A 1 78  SER 78  -60  ?   ?   ?   R . n 
A 1 79  PRO 79  -59  ?   ?   ?   R . n 
A 1 80  ASP 80  -58  ?   ?   ?   R . n 
A 1 81  SER 81  -57  ?   ?   ?   R . n 
A 1 82  PRO 82  -56  ?   ?   ?   R . n 
A 1 83  GLU 83  -55  ?   ?   ?   R . n 
A 1 84  MET 84  -54  ?   ?   ?   R . n 
A 1 85  LYS 85  -53  ?   ?   ?   R . n 
A 1 86  ASP 86  -52  ?   ?   ?   R . n 
A 1 87  PHE 87  -51  ?   ?   ?   R . n 
A 1 88  ARG 88  -50  ?   ?   ?   R . n 
A 1 89  HIS 89  -49  ?   ?   ?   R . n 
A 1 90  GLY 90  -48  ?   ?   ?   R . n 
A 1 91  PHE 91  -47  ?   ?   ?   R . n 
A 1 92  ASP 92  -46  ?   ?   ?   R . n 
A 1 93  ILE 93  -45  ?   ?   ?   R . n 
A 1 94  LEU 94  -44  ?   ?   ?   R . n 
A 1 95  VAL 95  -43  ?   ?   ?   R . n 
A 1 96  GLY 96  -42  ?   ?   ?   R . n 
A 1 97  GLN 97  -41  ?   ?   ?   R . n 
A 1 98  ILE 98  -40  ?   ?   ?   R . n 
A 1 99  ASP 99  -39  ?   ?   ?   R . n 
A 1 100 ASP 100 -38  ?   ?   ?   R . n 
A 1 101 ALA 101 -37  ?   ?   ?   R . n 
A 1 102 LEU 102 -36  ?   ?   ?   R . n 
A 1 103 LYS 103 -35  ?   ?   ?   R . n 
A 1 104 LEU 104 -34  ?   ?   ?   R . n 
A 1 105 ALA 105 -33  ?   ?   ?   R . n 
A 1 106 ASN 106 -32  ?   ?   ?   R . n 
A 1 107 GLU 107 -31  ?   ?   ?   R . n 
A 1 108 GLY 108 -30  ?   ?   ?   R . n 
A 1 109 LYS 109 -29  ?   ?   ?   R . n 
A 1 110 VAL 110 -28  ?   ?   ?   R . n 
A 1 111 LYS 111 -27  ?   ?   ?   R . n 
A 1 112 GLU 112 -26  ?   ?   ?   R . n 
A 1 113 ALA 113 -25  ?   ?   ?   R . n 
A 1 114 GLN 114 -24  ?   ?   ?   R . n 
A 1 115 ALA 115 -23  ?   ?   ?   R . n 
A 1 116 ALA 116 -22  ?   ?   ?   R . n 
A 1 117 ALA 117 -21  ?   ?   ?   R . n 
A 1 118 GLU 118 -20  ?   ?   ?   R . n 
A 1 119 GLN 119 -19  ?   ?   ?   R . n 
A 1 120 LEU 120 -18  ?   ?   ?   R . n 
A 1 121 LYS 121 -17  ?   ?   ?   R . n 
A 1 122 THR 122 -16  ?   ?   ?   R . n 
A 1 123 THR 123 -15  ?   ?   ?   R . n 
A 1 124 ARG 124 -14  ?   ?   ?   R . n 
A 1 125 ASN 125 -13  ?   ?   ?   R . n 
A 1 126 ALA 126 -12  ?   ?   ?   R . n 
A 1 127 TYR 127 -11  ?   ?   ?   R . n 
A 1 128 ILE 128 -10  ?   ?   ?   R . n 
A 1 129 GLN 129 -9   ?   ?   ?   R . n 
A 1 130 LYS 130 -8   ?   ?   ?   R . n 
A 1 131 TYR 131 -7   ?   ?   ?   R . n 
A 1 132 LEU 132 -6   ?   ?   ?   R . n 
A 1 133 LEU 133 -5   ?   ?   ?   R . n 
A 1 134 VAL 134 -4   ?   ?   ?   R . n 
A 1 135 PRO 135 -3   ?   ?   ?   R . n 
A 1 136 ARG 136 -2   ?   ?   ?   R . n 
A 1 137 GLY 137 -1   ?   ?   ?   R . n 
A 1 138 SER 138 0    ?   ?   ?   R . n 
A 1 139 MET 139 1    ?   ?   ?   R . n 
A 1 140 GLU 140 2    ?   ?   ?   R . n 
A 1 141 GLY 141 3    ?   ?   ?   R . n 
A 1 142 ILE 142 4    ?   ?   ?   R . n 
A 1 143 SER 143 5    ?   ?   ?   R . n 
A 1 144 ILE 144 6    ?   ?   ?   R . n 
A 1 145 TYR 145 7    ?   ?   ?   R . n 
A 1 146 THR 146 8    ?   ?   ?   R . n 
A 1 147 SER 147 9    ?   ?   ?   R . n 
A 1 148 ASP 148 10   ?   ?   ?   R . n 
A 1 149 ASN 149 11   ?   ?   ?   R . n 
A 1 150 TYR 150 12   ?   ?   ?   R . n 
A 1 151 THR 151 13   ?   ?   ?   R . n 
A 1 152 GLU 152 14   ?   ?   ?   R . n 
A 1 153 GLU 153 15   ?   ?   ?   R . n 
A 1 154 MET 154 16   ?   ?   ?   R . n 
A 1 155 GLY 155 17   ?   ?   ?   R . n 
A 1 156 SER 156 18   ?   ?   ?   R . n 
A 1 157 GLY 157 19   ?   ?   ?   R . n 
A 1 158 ASP 158 20   ?   ?   ?   R . n 
A 1 159 TYR 159 21   ?   ?   ?   R . n 
A 1 160 ASP 160 22   ?   ?   ?   R . n 
A 1 161 SER 161 23   ?   ?   ?   R . n 
A 1 162 MET 162 24   ?   ?   ?   R . n 
A 1 163 LYS 163 25   ?   ?   ?   R . n 
A 1 164 GLU 164 26   ?   ?   ?   R . n 
A 1 165 PRO 165 27   ?   ?   ?   R . n 
A 1 166 CYS 166 28   ?   ?   ?   R . n 
A 1 167 PHE 167 29   ?   ?   ?   R . n 
A 1 168 ARG 168 30   ?   ?   ?   R . n 
A 1 169 GLU 169 31   ?   ?   ?   R . n 
A 1 170 GLU 170 32   ?   ?   ?   R . n 
A 1 171 ASN 171 33   ?   ?   ?   R . n 
A 1 172 ALA 172 34   34  ALA ALA R . n 
A 1 173 ASN 173 35   35  ASN ASN R . n 
A 1 174 PHE 174 36   36  PHE PHE R . n 
A 1 175 ASN 175 37   37  ASN ASN R . n 
A 1 176 LYS 176 38   38  LYS LYS R . n 
A 1 177 ILE 177 39   39  ILE ILE R . n 
A 1 178 PHE 178 40   40  PHE PHE R . n 
A 1 179 LEU 179 41   41  LEU LEU R . n 
A 1 180 PRO 180 42   42  PRO PRO R . n 
A 1 181 THR 181 43   43  THR THR R . n 
A 1 182 ILE 182 44   44  ILE ILE R . n 
A 1 183 TYR 183 45   45  TYR TYR R . n 
A 1 184 SER 184 46   46  SER SER R . n 
A 1 185 ILE 185 47   47  ILE ILE R . n 
A 1 186 ILE 186 48   48  ILE ILE R . n 
A 1 187 PHE 187 49   49  PHE PHE R . n 
A 1 188 LEU 188 50   50  LEU LEU R . n 
A 1 189 THR 189 51   51  THR THR R . n 
A 1 190 GLY 190 52   52  GLY GLY R . n 
A 1 191 ILE 191 53   53  ILE ILE R . n 
A 1 192 VAL 192 54   54  VAL VAL R . n 
A 1 193 GLY 193 55   55  GLY GLY R . n 
A 1 194 ASN 194 56   56  ASN ASN R . n 
A 1 195 GLY 195 57   57  GLY GLY R . n 
A 1 196 LEU 196 58   58  LEU LEU R . n 
A 1 197 VAL 197 59   59  VAL VAL R . n 
A 1 198 ILE 198 60   60  ILE ILE R . n 
A 1 199 LEU 199 61   61  LEU LEU R . n 
A 1 200 VAL 200 62   62  VAL VAL R . n 
A 1 201 MET 201 63   63  MET MET R . n 
A 1 202 GLY 202 64   64  GLY GLY R . n 
A 1 203 TYR 203 65   65  TYR TYR R . n 
A 1 204 GLN 204 66   66  GLN GLN R . n 
A 1 205 LYS 205 67   67  LYS LYS R . n 
A 1 206 LYS 206 68   68  LYS LYS R . n 
A 1 207 LEU 207 69   69  LEU LEU R . n 
A 1 208 ARG 208 70   70  ARG ARG R . n 
A 1 209 SER 209 71   71  SER SER R . n 
A 1 210 MET 210 72   72  MET MET R . n 
A 1 211 THR 211 73   73  THR THR R . n 
A 1 212 ASP 212 74   74  ASP ASP R . n 
A 1 213 LYS 213 75   75  LYS LYS R . n 
A 1 214 TYR 214 76   76  TYR TYR R . n 
A 1 215 ARG 215 77   77  ARG ARG R . n 
A 1 216 LEU 216 78   78  LEU LEU R . n 
A 1 217 HIS 217 79   79  HIS HIS R . n 
A 1 218 LEU 218 80   80  LEU LEU R . n 
A 1 219 SER 219 81   81  SER SER R . n 
A 1 220 VAL 220 82   82  VAL VAL R . n 
A 1 221 ALA 221 83   83  ALA ALA R . n 
A 1 222 ASP 222 84   84  ASP ASP R . n 
A 1 223 LEU 223 85   85  LEU LEU R . n 
A 1 224 LEU 224 86   86  LEU LEU R . n 
A 1 225 PHE 225 87   87  PHE PHE R . n 
A 1 226 VAL 226 88   88  VAL VAL R . n 
A 1 227 ILE 227 89   89  ILE ILE R . n 
A 1 228 THR 228 90   90  THR THR R . n 
A 1 229 LEU 229 91   91  LEU LEU R . n 
A 1 230 PRO 230 92   92  PRO PRO R . n 
A 1 231 PHE 231 93   93  PHE PHE R . n 
A 1 232 TRP 232 94   94  TRP TRP R . n 
A 1 233 ALA 233 95   95  ALA ALA R . n 
A 1 234 VAL 234 96   96  VAL VAL R . n 
A 1 235 ASP 235 97   97  ASP ASP R . n 
A 1 236 ALA 236 98   98  ALA ALA R . n 
A 1 237 VAL 237 99   99  VAL VAL R . n 
A 1 238 ALA 238 100  100 ALA ALA R . n 
A 1 239 ASN 239 101  101 ASN ASN R . n 
A 1 240 TRP 240 102  102 TRP TRP R . n 
A 1 241 TYR 241 103  103 TYR TYR R . n 
A 1 242 PHE 242 104  104 PHE PHE R . n 
A 1 243 GLY 243 105  105 GLY GLY R . n 
A 1 244 ASN 244 106  106 ASN ASN R . n 
A 1 245 PHE 245 107  107 PHE PHE R . n 
A 1 246 LEU 246 108  108 LEU LEU R . n 
A 1 247 CYS 247 109  109 CYS CYS R . n 
A 1 248 LYS 248 110  110 LYS LYS R . n 
A 1 249 ALA 249 111  111 ALA ALA R . n 
A 1 250 VAL 250 112  112 VAL VAL R . n 
A 1 251 HIS 251 113  113 HIS HIS R . n 
A 1 252 VAL 252 114  114 VAL VAL R . n 
A 1 253 ILE 253 115  115 ILE ILE R . n 
A 1 254 TYR 254 116  116 TYR TYR R . n 
A 1 255 THR 255 117  117 THR THR R . n 
A 1 256 VAL 256 118  118 VAL VAL R . n 
A 1 257 ASN 257 119  119 ASN ASN R . n 
A 1 258 LEU 258 120  120 LEU LEU R . n 
A 1 259 TYR 259 121  121 TYR TYR R . n 
A 1 260 SER 260 122  122 SER SER R . n 
A 1 261 SER 261 123  123 SER SER R . n 
A 1 262 VAL 262 124  124 VAL VAL R . n 
A 1 263 TRP 263 125  125 TRP TRP R . n 
A 1 264 ILE 264 126  126 ILE ILE R . n 
A 1 265 LEU 265 127  127 LEU LEU R . n 
A 1 266 ALA 266 128  128 ALA ALA R . n 
A 1 267 PHE 267 129  129 PHE PHE R . n 
A 1 268 ILE 268 130  130 ILE ILE R . n 
A 1 269 SER 269 131  131 SER SER R . n 
A 1 270 LEU 270 132  132 LEU LEU R . n 
A 1 271 ASP 271 133  133 ASP ASP R . n 
A 1 272 ARG 272 134  134 ARG ARG R . n 
A 1 273 TYR 273 135  135 TYR TYR R . n 
A 1 274 LEU 274 136  136 LEU LEU R . n 
A 1 275 ALA 275 137  137 ALA ALA R . n 
A 1 276 ILE 276 138  138 ILE ILE R . n 
A 1 277 VAL 277 139  139 VAL VAL R . n 
A 1 278 HIS 278 140  140 HIS HIS R . n 
A 1 279 ALA 279 141  141 ALA ALA R . n 
A 1 280 THR 280 142  142 THR THR R . n 
A 1 281 ASN 281 143  143 ASN ASN R . n 
A 1 282 SER 282 144  144 SER SER R . n 
A 1 283 GLN 283 145  145 GLN GLN R . n 
A 1 284 ARG 284 146  146 ARG ARG R . n 
A 1 285 PRO 285 147  147 PRO PRO R . n 
A 1 286 ARG 286 148  148 ARG ARG R . n 
A 1 287 LYS 287 149  149 LYS LYS R . n 
A 1 288 LEU 288 150  150 LEU LEU R . n 
A 1 289 LEU 289 151  151 LEU LEU R . n 
A 1 290 ALA 290 152  152 ALA ALA R . n 
A 1 291 GLU 291 153  153 GLU GLU R . n 
A 1 292 LYS 292 154  154 LYS LYS R . n 
A 1 293 VAL 293 155  155 VAL VAL R . n 
A 1 294 VAL 294 156  156 VAL VAL R . n 
A 1 295 TYR 295 157  157 TYR TYR R . n 
A 1 296 VAL 296 158  158 VAL VAL R . n 
A 1 297 GLY 297 159  159 GLY GLY R . n 
A 1 298 VAL 298 160  160 VAL VAL R . n 
A 1 299 TRP 299 161  161 TRP TRP R . n 
A 1 300 ILE 300 162  162 ILE ILE R . n 
A 1 301 PRO 301 163  163 PRO PRO R . n 
A 1 302 ALA 302 164  164 ALA ALA R . n 
A 1 303 LEU 303 165  165 LEU LEU R . n 
A 1 304 LEU 304 166  166 LEU LEU R . n 
A 1 305 LEU 305 167  167 LEU LEU R . n 
A 1 306 THR 306 168  168 THR THR R . n 
A 1 307 ILE 307 169  169 ILE ILE R . n 
A 1 308 PRO 308 170  170 PRO PRO R . n 
A 1 309 ASP 309 171  171 ASP ASP R . n 
A 1 310 PHE 310 172  172 PHE PHE R . n 
A 1 311 ILE 311 173  173 ILE ILE R . n 
A 1 312 PHE 312 174  174 PHE PHE R . n 
A 1 313 ALA 313 175  175 ALA ALA R . n 
A 1 314 ASN 314 176  176 ASN ASN R . n 
A 1 315 VAL 315 177  177 VAL VAL R . n 
A 1 316 SER 316 178  178 SER SER R . n 
A 1 317 GLU 317 179  179 GLU GLU R . n 
A 1 318 ALA 318 180  180 ALA ALA R . n 
A 1 319 ASP 319 181  181 ASP ASP R . n 
A 1 320 ASP 320 182  182 ASP ASP R . n 
A 1 321 ARG 321 183  183 ARG ARG R . n 
A 1 322 TYR 322 184  184 TYR TYR R . n 
A 1 323 ILE 323 185  185 ILE ILE R . n 
A 1 324 CYS 324 186  186 CYS CYS R . n 
A 1 325 ASP 325 187  187 ASP ASP R . n 
A 1 326 ARG 326 188  188 ARG ARG R . n 
A 1 327 PHE 327 189  189 PHE PHE R . n 
A 1 328 TYR 328 190  190 TYR TYR R . n 
A 1 329 PRO 329 191  191 PRO PRO R . n 
A 1 330 ASN 330 192  192 ASN ASN R . n 
A 1 331 ASP 331 193  193 ASP ASP R . n 
A 1 332 LEU 332 194  194 LEU LEU R . n 
A 1 333 TRP 333 195  195 TRP TRP R . n 
A 1 334 VAL 334 196  196 VAL VAL R . n 
A 1 335 VAL 335 197  197 VAL VAL R . n 
A 1 336 VAL 336 198  198 VAL VAL R . n 
A 1 337 PHE 337 199  199 PHE PHE R . n 
A 1 338 GLN 338 200  200 GLN GLN R . n 
A 1 339 PHE 339 201  201 PHE PHE R . n 
A 1 340 GLN 340 202  202 GLN GLN R . n 
A 1 341 HIS 341 203  203 HIS HIS R . n 
A 1 342 ILE 342 204  204 ILE ILE R . n 
A 1 343 MET 343 205  205 MET MET R . n 
A 1 344 VAL 344 206  206 VAL VAL R . n 
A 1 345 GLY 345 207  207 GLY GLY R . n 
A 1 346 LEU 346 208  208 LEU LEU R . n 
A 1 347 ILE 347 209  209 ILE ILE R . n 
A 1 348 LEU 348 210  210 LEU LEU R . n 
A 1 349 PRO 349 211  211 PRO PRO R . n 
A 1 350 GLY 350 212  212 GLY GLY R . n 
A 1 351 ILE 351 213  213 ILE ILE R . n 
A 1 352 VAL 352 214  214 VAL VAL R . n 
A 1 353 ILE 353 215  215 ILE ILE R . n 
A 1 354 LEU 354 216  216 LEU LEU R . n 
A 1 355 SER 355 217  217 SER SER R . n 
A 1 356 CYS 356 218  218 CYS CYS R . n 
A 1 357 TYR 357 219  219 TYR TYR R . n 
A 1 358 CYS 358 220  220 CYS CYS R . n 
A 1 359 ILE 359 221  221 ILE ILE R . n 
A 1 360 ILE 360 222  222 ILE ILE R . n 
A 1 361 ILE 361 223  223 ILE ILE R . n 
A 1 362 SER 362 224  224 SER SER R . n 
A 1 363 ARG 363 225  225 ARG ARG R . n 
A 1 364 LEU 364 226  226 LEU LEU R . n 
A 1 365 LYS 365 227  227 LYS LYS R . n 
A 1 366 SER 366 228  228 SER SER R . n 
A 1 367 VAL 367 229  229 VAL VAL R . n 
A 1 368 ARG 368 230  230 ARG ARG R . n 
A 1 369 LEU 369 231  231 LEU LEU R . n 
A 1 370 LEU 370 232  232 LEU LEU R . n 
A 1 371 SER 371 233  233 SER SER R . n 
A 1 372 GLY 372 234  234 GLY GLY R . n 
A 1 373 SER 373 235  235 SER SER R . n 
A 1 374 ARG 374 236  236 ARG ARG R . n 
A 1 375 GLU 375 237  237 GLU GLU R . n 
A 1 376 LYS 376 238  238 LYS LYS R . n 
A 1 377 ASP 377 239  239 ASP ASP R . n 
A 1 378 ARG 378 240  240 ARG ARG R . n 
A 1 379 ASN 379 241  241 ASN ASN R . n 
A 1 380 LEU 380 242  242 LEU LEU R . n 
A 1 381 ARG 381 243  243 ARG ARG R . n 
A 1 382 ARG 382 244  244 ARG ARG R . n 
A 1 383 ILE 383 245  245 ILE ILE R . n 
A 1 384 THR 384 246  246 THR THR R . n 
A 1 385 ARG 385 247  247 ARG ARG R . n 
A 1 386 PRO 386 248  248 PRO PRO R . n 
A 1 387 THR 387 249  249 THR THR R . n 
A 1 388 VAL 388 250  250 VAL VAL R . n 
A 1 389 ILE 389 251  251 ILE ILE R . n 
A 1 390 LEU 390 252  252 LEU LEU R . n 
A 1 391 ILE 391 253  253 ILE ILE R . n 
A 1 392 LEU 392 254  254 LEU LEU R . n 
A 1 393 ALA 393 255  255 ALA ALA R . n 
A 1 394 PHE 394 256  256 PHE PHE R . n 
A 1 395 PHE 395 257  257 PHE PHE R . n 
A 1 396 ALA 396 258  258 ALA ALA R . n 
A 1 397 CYS 397 259  259 CYS CYS R . n 
A 1 398 TRP 398 260  260 TRP TRP R . n 
A 1 399 LEU 399 261  261 LEU LEU R . n 
A 1 400 PRO 400 262  262 PRO PRO R . n 
A 1 401 TYR 401 263  263 TYR TYR R . n 
A 1 402 TYR 402 264  264 TYR TYR R . n 
A 1 403 ILE 403 265  265 ILE ILE R . n 
A 1 404 GLY 404 266  266 GLY GLY R . n 
A 1 405 ILE 405 267  267 ILE ILE R . n 
A 1 406 SER 406 268  268 SER SER R . n 
A 1 407 ILE 407 269  269 ILE ILE R . n 
A 1 408 ASP 408 270  270 ASP ASP R . n 
A 1 409 SER 409 271  271 SER SER R . n 
A 1 410 PHE 410 272  272 PHE PHE R . n 
A 1 411 ILE 411 273  273 ILE ILE R . n 
A 1 412 LEU 412 274  274 LEU LEU R . n 
A 1 413 LEU 413 275  275 LEU LEU R . n 
A 1 414 GLU 414 276  276 GLU GLU R . n 
A 1 415 ILE 415 277  277 ILE ILE R . n 
A 1 416 ILE 416 278  278 ILE ILE R . n 
A 1 417 LYS 417 279  279 LYS LYS R . n 
A 1 418 GLN 418 280  280 GLN GLN R . n 
A 1 419 GLY 419 281  281 GLY GLY R . n 
A 1 420 CYS 420 282  282 CYS CYS R . n 
A 1 421 GLU 421 283  283 GLU GLU R . n 
A 1 422 PHE 422 284  284 PHE PHE R . n 
A 1 423 GLU 423 285  285 GLU GLU R . n 
A 1 424 ASN 424 286  286 ASN ASN R . n 
A 1 425 THR 425 287  287 THR THR R . n 
A 1 426 VAL 426 288  288 VAL VAL R . n 
A 1 427 HIS 427 289  289 HIS HIS R . n 
A 1 428 LYS 428 290  290 LYS LYS R . n 
A 1 429 TRP 429 291  291 TRP TRP R . n 
A 1 430 ILE 430 292  292 ILE ILE R . n 
A 1 431 SER 431 293  293 SER SER R . n 
A 1 432 ILE 432 294  294 ILE ILE R . n 
A 1 433 THR 433 295  295 THR THR R . n 
A 1 434 GLU 434 296  296 GLU GLU R . n 
A 1 435 ALA 435 297  297 ALA ALA R . n 
A 1 436 LEU 436 298  298 LEU LEU R . n 
A 1 437 ALA 437 299  299 ALA ALA R . n 
A 1 438 PHE 438 300  300 PHE PHE R . n 
A 1 439 PHE 439 301  301 PHE PHE R . n 
A 1 440 HIS 440 302  302 HIS HIS R . n 
A 1 441 CYS 441 303  303 CYS CYS R . n 
A 1 442 CYS 442 304  304 CYS CYS R . n 
A 1 443 LEU 443 305  305 LEU LEU R . n 
A 1 444 ASN 444 306  306 ASN ASN R . n 
A 1 445 PRO 445 307  307 PRO PRO R . n 
A 1 446 ILE 446 308  308 ILE ILE R . n 
A 1 447 LEU 447 309  309 LEU LEU R . n 
A 1 448 TYR 448 310  310 TYR TYR R . n 
A 1 449 ALA 449 311  311 ALA ALA R . n 
A 1 450 PHE 450 312  312 PHE PHE R . n 
A 1 451 LEU 451 313  313 LEU LEU R . n 
A 1 452 GLY 452 314  314 GLY GLY R . n 
A 1 453 ALA 453 315  315 ALA ALA R . n 
A 1 454 LYS 454 316  ?   ?   ?   R . n 
A 1 455 PHE 455 317  ?   ?   ?   R . n 
A 1 456 LYS 456 318  ?   ?   ?   R . n 
A 1 457 THR 457 319  ?   ?   ?   R . n 
A 1 458 SER 458 320  ?   ?   ?   R . n 
A 1 459 ALA 459 321  ?   ?   ?   R . n 
A 1 460 GLN 460 322  ?   ?   ?   R . n 
A 1 461 HIS 461 323  ?   ?   ?   R . n 
A 1 462 ALA 462 324  ?   ?   ?   R . n 
A 1 463 LEU 463 325  ?   ?   ?   R . n 
A 1 464 THR 464 326  ?   ?   ?   R . n 
A 1 465 SER 465 327  ?   ?   ?   R . n 
A 1 466 GLY 466 328  ?   ?   ?   R . n 
A 1 467 ARG 467 329  ?   ?   ?   R . n 
A 1 468 PRO 468 330  ?   ?   ?   R . n 
A 1 469 LEU 469 331  ?   ?   ?   R . n 
A 1 470 GLU 470 332  ?   ?   ?   R . n 
A 1 471 VAL 471 333  ?   ?   ?   R . n 
A 1 472 LEU 472 334  ?   ?   ?   R . n 
A 1 473 PHE 473 335  ?   ?   ?   R . n 
A 1 474 GLN 474 336  ?   ?   ?   R . n 
A 1 475 GLY 475 337  ?   ?   ?   R . n 
A 1 476 PRO 476 338  ?   ?   ?   R . n 
A 1 477 HIS 477 339  ?   ?   ?   R . n 
A 1 478 HIS 478 340  ?   ?   ?   R . n 
A 1 479 HIS 479 341  ?   ?   ?   R . n 
A 1 480 HIS 480 342  ?   ?   ?   R . n 
A 1 481 HIS 481 343  ?   ?   ?   R . n 
A 1 482 HIS 482 344  ?   ?   ?   R . n 
A 1 483 HIS 483 345  ?   ?   ?   R . n 
A 1 484 HIS 484 346  ?   ?   ?   R . n 
A 1 485 HIS 485 347  ?   ?   ?   R . n 
A 1 486 HIS 486 348  ?   ?   ?   R . n 
B 2 1   MET 1   -37  ?   ?   ?   N . n 
B 2 2   LEU 2   -36  ?   ?   ?   N . n 
B 2 3   LEU 3   -35  ?   ?   ?   N . n 
B 2 4   VAL 4   -34  ?   ?   ?   N . n 
B 2 5   ASN 5   -33  ?   ?   ?   N . n 
B 2 6   GLN 6   -32  ?   ?   ?   N . n 
B 2 7   SER 7   -31  ?   ?   ?   N . n 
B 2 8   HIS 8   -30  ?   ?   ?   N . n 
B 2 9   GLN 9   -29  ?   ?   ?   N . n 
B 2 10  GLY 10  -28  ?   ?   ?   N . n 
B 2 11  PHE 11  -27  ?   ?   ?   N . n 
B 2 12  ASN 12  -26  ?   ?   ?   N . n 
B 2 13  LYS 13  -25  ?   ?   ?   N . n 
B 2 14  GLU 14  -24  ?   ?   ?   N . n 
B 2 15  HIS 15  -23  ?   ?   ?   N . n 
B 2 16  THR 16  -22  ?   ?   ?   N . n 
B 2 17  SER 17  -21  ?   ?   ?   N . n 
B 2 18  LYS 18  -20  ?   ?   ?   N . n 
B 2 19  MET 19  -19  ?   ?   ?   N . n 
B 2 20  VAL 20  -18  ?   ?   ?   N . n 
B 2 21  SER 21  -17  ?   ?   ?   N . n 
B 2 22  ALA 22  -16  ?   ?   ?   N . n 
B 2 23  ILE 23  -15  ?   ?   ?   N . n 
B 2 24  VAL 24  -14  ?   ?   ?   N . n 
B 2 25  LEU 25  -13  ?   ?   ?   N . n 
B 2 26  TYR 26  -12  ?   ?   ?   N . n 
B 2 27  VAL 27  -11  ?   ?   ?   N . n 
B 2 28  LEU 28  -10  ?   ?   ?   N . n 
B 2 29  LEU 29  -9   ?   ?   ?   N . n 
B 2 30  ALA 30  -8   ?   ?   ?   N . n 
B 2 31  ALA 31  -7   ?   ?   ?   N . n 
B 2 32  ALA 32  -6   ?   ?   ?   N . n 
B 2 33  ALA 33  -5   ?   ?   ?   N . n 
B 2 34  HIS 34  -4   ?   ?   ?   N . n 
B 2 35  SER 35  -3   ?   ?   ?   N . n 
B 2 36  ALA 36  -2   ?   ?   ?   N . n 
B 2 37  PHE 37  -1   ?   ?   ?   N . n 
B 2 38  ALA 38  0    ?   ?   ?   N . n 
B 2 39  MET 39  1    ?   ?   ?   N . n 
B 2 40  ALA 40  2    ?   ?   ?   N . n 
B 2 41  GLN 41  3    3   GLN GLN N . n 
B 2 42  VAL 42  4    4   VAL VAL N . n 
B 2 43  GLN 43  5    5   GLN GLN N . n 
B 2 44  LEU 44  6    6   LEU LEU N . n 
B 2 45  GLN 45  7    7   GLN GLN N . n 
B 2 46  GLU 46  8    8   GLU GLU N . n 
B 2 47  SER 47  9    9   SER SER N . n 
B 2 48  GLY 48  10   10  GLY GLY N . n 
B 2 49  GLY 49  11   11  GLY GLY N . n 
B 2 50  GLY 50  12   12  GLY GLY N . n 
B 2 51  LEU 51  13   13  LEU LEU N . n 
B 2 52  VAL 52  14   14  VAL VAL N . n 
B 2 53  GLN 53  15   15  GLN GLN N . n 
B 2 54  ALA 54  16   16  ALA ALA N . n 
B 2 55  GLY 55  17   17  GLY GLY N . n 
B 2 56  GLU 56  18   18  GLU GLU N . n 
B 2 57  SER 57  19   19  SER SER N . n 
B 2 58  LEU 58  20   20  LEU LEU N . n 
B 2 59  ARG 59  21   21  ARG ARG N . n 
B 2 60  LEU 60  22   22  LEU LEU N . n 
B 2 61  SER 61  23   23  SER SER N . n 
B 2 62  CYS 62  24   24  CYS CYS N . n 
B 2 63  ALA 63  25   25  ALA ALA N . n 
B 2 64  ALA 64  26   26  ALA ALA N . n 
B 2 65  SER 65  27   27  SER SER N . n 
B 2 66  GLY 66  28   28  GLY GLY N . n 
B 2 67  THR 67  29   29  THR THR N . n 
B 2 68  ILE 68  30   30  ILE ILE N . n 
B 2 69  PHE 69  31   31  PHE PHE N . n 
B 2 70  ARG 70  32   32  ARG ARG N . n 
B 2 71  LEU 71  33   33  LEU LEU N . n 
B 2 72  TYR 72  34   34  TYR TYR N . n 
B 2 73  ASP 73  35   35  ASP ASP N . n 
B 2 74  MET 74  36   36  MET MET N . n 
B 2 75  GLY 75  37   37  GLY GLY N . n 
B 2 76  TRP 76  38   38  TRP TRP N . n 
B 2 77  TYR 77  39   39  TYR TYR N . n 
B 2 78  ARG 78  40   40  ARG ARG N . n 
B 2 79  ARG 79  41   ?   ?   ?   N . n 
B 2 80  VAL 80  42   ?   ?   ?   N . n 
B 2 81  SER 81  43   ?   ?   ?   N . n 
B 2 82  GLY 82  44   ?   ?   ?   N . n 
B 2 83  ASN 83  45   ?   ?   ?   N . n 
B 2 84  GLN 84  46   46  GLN GLN N . n 
B 2 85  ARG 85  47   47  ARG ARG N . n 
B 2 86  GLU 86  48   48  GLU GLU N . n 
B 2 87  LEU 87  49   49  LEU LEU N . n 
B 2 88  VAL 88  50   50  VAL VAL N . n 
B 2 89  ALA 89  51   51  ALA ALA N . n 
B 2 90  SER 90  52   52  SER SER N . n 
B 2 91  ILE 91  53   53  ILE ILE N . n 
B 2 92  THR 92  54   54  THR THR N . n 
B 2 93  SER 93  55   55  SER SER N . n 
B 2 94  GLY 94  56   56  GLY GLY N . n 
B 2 95  GLY 95  57   57  GLY GLY N . n 
B 2 96  SER 96  58   58  SER SER N . n 
B 2 97  THR 97  59   59  THR THR N . n 
B 2 98  LYS 98  60   60  LYS LYS N . n 
B 2 99  TYR 99  61   61  TYR TYR N . n 
B 2 100 GLY 100 62   62  GLY GLY N . n 
B 2 101 ASP 101 63   63  ASP ASP N . n 
B 2 102 SER 102 64   64  SER SER N . n 
B 2 103 VAL 103 65   65  VAL VAL N . n 
B 2 104 LYS 104 66   66  LYS LYS N . n 
B 2 105 GLY 105 67   67  GLY GLY N . n 
B 2 106 ARG 106 68   68  ARG ARG N . n 
B 2 107 PHE 107 69   69  PHE PHE N . n 
B 2 108 THR 108 70   70  THR THR N . n 
B 2 109 ILE 109 71   71  ILE ILE N . n 
B 2 110 SER 110 72   72  SER SER N . n 
B 2 111 ARG 111 73   73  ARG ARG N . n 
B 2 112 ASP 112 74   74  ASP ASP N . n 
B 2 113 ASN 113 75   75  ASN ASN N . n 
B 2 114 ALA 114 76   76  ALA ALA N . n 
B 2 115 LYS 115 77   77  LYS LYS N . n 
B 2 116 ASN 116 78   78  ASN ASN N . n 
B 2 117 THR 117 79   79  THR THR N . n 
B 2 118 VAL 118 80   80  VAL VAL N . n 
B 2 119 TYR 119 81   81  TYR TYR N . n 
B 2 120 LEU 120 82   82  LEU LEU N . n 
B 2 121 GLN 121 83   83  GLN GLN N . n 
B 2 122 MET 122 84   84  MET MET N . n 
B 2 123 SER 123 85   85  SER SER N . n 
B 2 124 SER 124 86   86  SER SER N . n 
B 2 125 LEU 125 87   87  LEU LEU N . n 
B 2 126 LYS 126 88   88  LYS LYS N . n 
B 2 127 PRO 127 89   89  PRO PRO N . n 
B 2 128 GLU 128 90   90  GLU GLU N . n 
B 2 129 ASP 129 91   91  ASP ASP N . n 
B 2 130 THR 130 92   92  THR THR N . n 
B 2 131 ALA 131 93   93  ALA ALA N . n 
B 2 132 VAL 132 94   94  VAL VAL N . n 
B 2 133 TYR 133 95   95  TYR TYR N . n 
B 2 134 TYR 134 96   96  TYR TYR N . n 
B 2 135 CYS 135 97   97  CYS CYS N . n 
B 2 136 ASN 136 98   98  ASN ASN N . n 
B 2 137 ALA 137 99   99  ALA ALA N . n 
B 2 138 GLU 138 100  100 GLU GLU N . n 
B 2 139 TYR 139 101  101 TYR TYR N . n 
B 2 140 ARG 140 102  102 ARG ARG N . n 
B 2 141 THR 141 103  103 THR THR N . n 
B 2 142 GLY 142 104  104 GLY GLY N . n 
B 2 143 ILE 143 105  105 ILE ILE N . n 
B 2 144 TRP 144 106  106 TRP TRP N . n 
B 2 145 GLU 145 107  107 GLU GLU N . n 
B 2 146 GLU 146 108  108 GLU GLU N . n 
B 2 147 LEU 147 109  109 LEU LEU N . n 
B 2 148 LEU 148 110  110 LEU LEU N . n 
B 2 149 ASP 149 111  111 ASP ASP N . n 
B 2 150 GLY 150 112  112 GLY GLY N . n 
B 2 151 TRP 151 113  113 TRP TRP N . n 
B 2 152 GLY 152 114  114 GLY GLY N . n 
B 2 153 GLN 153 115  115 GLN GLN N . n 
B 2 154 GLY 154 116  116 GLY GLY N . n 
B 2 155 THR 155 117  117 THR THR N . n 
B 2 156 GLN 156 118  118 GLN GLN N . n 
B 2 157 VAL 157 119  119 VAL VAL N . n 
B 2 158 THR 158 120  120 THR THR N . n 
B 2 159 VAL 159 121  121 VAL VAL N . n 
B 2 160 SER 160 122  122 SER SER N . n 
B 2 161 SER 161 123  123 SER SER N . n 
B 2 162 HIS 162 124  ?   ?   ?   N . n 
B 2 163 HIS 163 125  ?   ?   ?   N . n 
B 2 164 HIS 164 126  ?   ?   ?   N . n 
B 2 165 HIS 165 127  ?   ?   ?   N . n 
B 2 166 HIS 166 128  ?   ?   ?   N . n 
B 2 167 HIS 167 129  ?   ?   ?   N . n 
B 2 168 HIS 168 130  ?   ?   ?   N . n 
B 2 169 HIS 169 131  ?   ?   ?   N . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1D8L 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1D8L 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 A1D8L 1 401 1   A1D8L 070 R . 
D 4 CLR   1 402 402 CLR   CLR R . 
E 4 CLR   1 403 403 CLR   CLR R . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 N GLN 3   ? CG  ? B GLN 41  CG  
2  1 Y 1 N GLN 3   ? CD  ? B GLN 41  CD  
3  1 Y 1 N GLN 3   ? OE1 ? B GLN 41  OE1 
4  1 Y 1 N GLN 3   ? NE2 ? B GLN 41  NE2 
5  1 Y 1 N GLN 5   ? CG  ? B GLN 43  CG  
6  1 Y 1 N GLN 5   ? CD  ? B GLN 43  CD  
7  1 Y 1 N GLN 5   ? OE1 ? B GLN 43  OE1 
8  1 Y 1 N GLN 5   ? NE2 ? B GLN 43  NE2 
9  1 Y 1 N LEU 13  ? CG  ? B LEU 51  CG  
10 1 Y 1 N LEU 13  ? CD1 ? B LEU 51  CD1 
11 1 Y 1 N LEU 13  ? CD2 ? B LEU 51  CD2 
12 1 Y 1 N GLN 15  ? CG  ? B GLN 53  CG  
13 1 Y 1 N GLN 15  ? CD  ? B GLN 53  CD  
14 1 Y 1 N GLN 15  ? OE1 ? B GLN 53  OE1 
15 1 Y 1 N GLN 15  ? NE2 ? B GLN 53  NE2 
16 1 Y 1 N SER 27  ? OG  ? B SER 65  OG  
17 1 Y 1 N LEU 49  ? CG  ? B LEU 87  CG  
18 1 Y 1 N LEU 49  ? CD1 ? B LEU 87  CD1 
19 1 Y 1 N LEU 49  ? CD2 ? B LEU 87  CD2 
20 1 Y 1 N SER 52  ? OG  ? B SER 90  OG  
21 1 Y 1 N SER 58  ? OG  ? B SER 96  OG  
22 1 Y 1 N LYS 60  ? CG  ? B LYS 98  CG  
23 1 Y 1 N LYS 60  ? CD  ? B LYS 98  CD  
24 1 Y 1 N LYS 60  ? CE  ? B LYS 98  CE  
25 1 Y 1 N LYS 60  ? NZ  ? B LYS 98  NZ  
26 1 Y 1 N ASP 63  ? CG  ? B ASP 101 CG  
27 1 Y 1 N ASP 63  ? OD1 ? B ASP 101 OD1 
28 1 Y 1 N ASP 63  ? OD2 ? B ASP 101 OD2 
29 1 Y 1 N SER 64  ? OG  ? B SER 102 OG  
30 1 Y 1 N VAL 65  ? CG1 ? B VAL 103 CG1 
31 1 Y 1 N VAL 65  ? CG2 ? B VAL 103 CG2 
32 1 Y 1 N LYS 66  ? CG  ? B LYS 104 CG  
33 1 Y 1 N LYS 66  ? CD  ? B LYS 104 CD  
34 1 Y 1 N LYS 66  ? CE  ? B LYS 104 CE  
35 1 Y 1 N LYS 66  ? NZ  ? B LYS 104 NZ  
36 1 Y 1 N LYS 77  ? CG  ? B LYS 115 CG  
37 1 Y 1 N LYS 77  ? CD  ? B LYS 115 CD  
38 1 Y 1 N LYS 77  ? CE  ? B LYS 115 CE  
39 1 Y 1 N LYS 77  ? NZ  ? B LYS 115 NZ  
40 1 Y 1 N LYS 88  ? CG  ? B LYS 126 CG  
41 1 Y 1 N LYS 88  ? CD  ? B LYS 126 CD  
42 1 Y 1 N LYS 88  ? CE  ? B LYS 126 CE  
43 1 Y 1 N LYS 88  ? NZ  ? B LYS 126 NZ  
44 1 Y 1 N VAL 121 ? CG1 ? B VAL 159 CG1 
45 1 Y 1 N VAL 121 ? CG2 ? B VAL 159 CG2 
46 1 Y 1 N SER 122 ? OG  ? B SER 160 OG  
47 1 Y 1 N SER 123 ? OG  ? B SER 161 OG  
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZPM 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZPM 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZPM 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8ZPM 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003 ? 3308 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.580 ? 4516 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 5.155 ? 467  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.043 ? 524  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004 ? 543  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8ZPM 
_struct.title                        'Cryo-EM strucutre of CXCR4 complexed with antagonist AMD070' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZPM 
_struct_keywords.text            'CXC motif chemokine receptor 4, antagonist, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP C562_ECOLX  P0ABE7 ? 1 
;ADLEDNMETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLAN
EGKVKEAQAAAEQLKTTRNAYHQKY
;
23  
2 UNP CXCR4_HUMAN P61073 ? 1 
;MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHL
SVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGV
WIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIIS
;
1   
3 UNP CXCR4_HUMAN P61073 ? 1 TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTS 241 
4 PDB 8ZPM        8ZPM   ? 2 ? 1   
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZPM R 27  ? 131 ? P0ABE7 23  ? 127 ? -111 -7  
2 2 8ZPM R 139 ? 362 ? P61073 1   ? 224 ? 1    224 
3 3 8ZPM R 387 ? 465 ? P61073 241 ? 319 ? 249  327 
4 4 8ZPM N 1   ? 169 ? 8ZPM   -37 ? 131 ? -37  131 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZPM MET R 1   ? UNP P0ABE7 ?   ?   'initiating methionine' -137 1  
1 8ZPM LYS R 2   ? UNP P0ABE7 ?   ?   'expression tag'        -136 2  
1 8ZPM THR R 3   ? UNP P0ABE7 ?   ?   'expression tag'        -135 3  
1 8ZPM ILE R 4   ? UNP P0ABE7 ?   ?   'expression tag'        -134 4  
1 8ZPM ILE R 5   ? UNP P0ABE7 ?   ?   'expression tag'        -133 5  
1 8ZPM ALA R 6   ? UNP P0ABE7 ?   ?   'expression tag'        -132 6  
1 8ZPM LEU R 7   ? UNP P0ABE7 ?   ?   'expression tag'        -131 7  
1 8ZPM SER R 8   ? UNP P0ABE7 ?   ?   'expression tag'        -130 8  
1 8ZPM TYR R 9   ? UNP P0ABE7 ?   ?   'expression tag'        -129 9  
1 8ZPM ILE R 10  ? UNP P0ABE7 ?   ?   'expression tag'        -128 10 
1 8ZPM PHE R 11  ? UNP P0ABE7 ?   ?   'expression tag'        -127 11 
1 8ZPM CYS R 12  ? UNP P0ABE7 ?   ?   'expression tag'        -126 12 
1 8ZPM LEU R 13  ? UNP P0ABE7 ?   ?   'expression tag'        -125 13 
1 8ZPM VAL R 14  ? UNP P0ABE7 ?   ?   'expression tag'        -124 14 
1 8ZPM PHE R 15  ? UNP P0ABE7 ?   ?   'expression tag'        -123 15 
1 8ZPM ALA R 16  ? UNP P0ABE7 ?   ?   'expression tag'        -122 16 
1 8ZPM ASP R 17  ? UNP P0ABE7 ?   ?   'expression tag'        -121 17 
1 8ZPM TYR R 18  ? UNP P0ABE7 ?   ?   'expression tag'        -120 18 
1 8ZPM LYS R 19  ? UNP P0ABE7 ?   ?   'expression tag'        -119 19 
1 8ZPM ASP R 20  ? UNP P0ABE7 ?   ?   'expression tag'        -118 20 
1 8ZPM ASP R 21  ? UNP P0ABE7 ?   ?   'expression tag'        -117 21 
1 8ZPM ASP R 22  ? UNP P0ABE7 ?   ?   'expression tag'        -116 22 
1 8ZPM ASP R 23  ? UNP P0ABE7 ?   ?   'expression tag'        -115 23 
1 8ZPM LYS R 24  ? UNP P0ABE7 ?   ?   'expression tag'        -114 24 
1 8ZPM GLY R 25  ? UNP P0ABE7 ?   ?   'expression tag'        -113 25 
1 8ZPM SER R 26  ? UNP P0ABE7 ?   ?   'expression tag'        -112 26 
1 8ZPM TRP R 33  ? UNP P0ABE7 MET 29  conflict                -105 27 
1 8ZPM ILE R 128 ? UNP P0ABE7 HIS 124 conflict                -10  28 
1 8ZPM LEU R 132 ? UNP P0ABE7 ?   ?   linker                  -6   29 
1 8ZPM LEU R 133 ? UNP P0ABE7 ?   ?   linker                  -5   30 
1 8ZPM VAL R 134 ? UNP P0ABE7 ?   ?   linker                  -4   31 
1 8ZPM PRO R 135 ? UNP P0ABE7 ?   ?   linker                  -3   32 
1 8ZPM ARG R 136 ? UNP P0ABE7 ?   ?   linker                  -2   33 
1 8ZPM GLY R 137 ? UNP P0ABE7 ?   ?   linker                  -1   34 
1 8ZPM SER R 138 ? UNP P0ABE7 ?   ?   linker                  0    35 
2 8ZPM TRP R 263 ? UNP P61073 LEU 125 conflict                125  36 
2 8ZPM ARG R 363 ? UNP P61073 ?   ?   linker                  225  37 
2 8ZPM LEU R 364 ? UNP P61073 ?   ?   linker                  226  38 
2 8ZPM LYS R 365 ? UNP P61073 ?   ?   linker                  227  39 
2 8ZPM SER R 366 ? UNP P61073 ?   ?   linker                  228  40 
2 8ZPM VAL R 367 ? UNP P61073 ?   ?   linker                  229  41 
2 8ZPM ARG R 368 ? UNP P61073 ?   ?   linker                  230  42 
2 8ZPM LEU R 369 ? UNP P61073 ?   ?   linker                  231  43 
2 8ZPM LEU R 370 ? UNP P61073 ?   ?   linker                  232  44 
2 8ZPM SER R 371 ? UNP P61073 ?   ?   linker                  233  45 
2 8ZPM GLY R 372 ? UNP P61073 ?   ?   linker                  234  46 
2 8ZPM SER R 373 ? UNP P61073 ?   ?   linker                  235  47 
2 8ZPM ARG R 374 ? UNP P61073 ?   ?   linker                  236  48 
2 8ZPM GLU R 375 ? UNP P61073 ?   ?   linker                  237  49 
2 8ZPM LYS R 376 ? UNP P61073 ?   ?   linker                  238  50 
2 8ZPM ASP R 377 ? UNP P61073 ?   ?   linker                  239  51 
2 8ZPM ARG R 378 ? UNP P61073 ?   ?   linker                  240  52 
2 8ZPM ASN R 379 ? UNP P61073 ?   ?   linker                  241  53 
2 8ZPM LEU R 380 ? UNP P61073 ?   ?   linker                  242  54 
2 8ZPM ARG R 381 ? UNP P61073 ?   ?   linker                  243  55 
2 8ZPM ARG R 382 ? UNP P61073 ?   ?   linker                  244  56 
2 8ZPM ILE R 383 ? UNP P61073 ?   ?   linker                  245  57 
2 8ZPM THR R 384 ? UNP P61073 ?   ?   linker                  246  58 
2 8ZPM ARG R 385 ? UNP P61073 ?   ?   linker                  247  59 
2 8ZPM PRO R 386 ? UNP P61073 ?   ?   linker                  248  60 
3 8ZPM GLY R 466 ? UNP P61073 ?   ?   'expression tag'        328  61 
3 8ZPM ARG R 467 ? UNP P61073 ?   ?   'expression tag'        329  62 
3 8ZPM PRO R 468 ? UNP P61073 ?   ?   'expression tag'        330  63 
3 8ZPM LEU R 469 ? UNP P61073 ?   ?   'expression tag'        331  64 
3 8ZPM GLU R 470 ? UNP P61073 ?   ?   'expression tag'        332  65 
3 8ZPM VAL R 471 ? UNP P61073 ?   ?   'expression tag'        333  66 
3 8ZPM LEU R 472 ? UNP P61073 ?   ?   'expression tag'        334  67 
3 8ZPM PHE R 473 ? UNP P61073 ?   ?   'expression tag'        335  68 
3 8ZPM GLN R 474 ? UNP P61073 ?   ?   'expression tag'        336  69 
3 8ZPM GLY R 475 ? UNP P61073 ?   ?   'expression tag'        337  70 
3 8ZPM PRO R 476 ? UNP P61073 ?   ?   'expression tag'        338  71 
3 8ZPM HIS R 477 ? UNP P61073 ?   ?   'expression tag'        339  72 
3 8ZPM HIS R 478 ? UNP P61073 ?   ?   'expression tag'        340  73 
3 8ZPM HIS R 479 ? UNP P61073 ?   ?   'expression tag'        341  74 
3 8ZPM HIS R 480 ? UNP P61073 ?   ?   'expression tag'        342  75 
3 8ZPM HIS R 481 ? UNP P61073 ?   ?   'expression tag'        343  76 
3 8ZPM HIS R 482 ? UNP P61073 ?   ?   'expression tag'        344  77 
3 8ZPM HIS R 483 ? UNP P61073 ?   ?   'expression tag'        345  78 
3 8ZPM HIS R 484 ? UNP P61073 ?   ?   'expression tag'        346  79 
3 8ZPM HIS R 485 ? UNP P61073 ?   ?   'expression tag'        347  80 
3 8ZPM HIS R 486 ? UNP P61073 ?   ?   'expression tag'        348  81 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 172 ? GLY A 202 ? ALA R 34  GLY R 64  1 ? 31 
HELX_P HELX_P2  AA2 SER A 209 ? ILE A 227 ? SER R 71  ILE R 89  1 ? 19 
HELX_P HELX_P3  AA3 THR A 228 ? ALA A 238 ? THR R 90  ALA R 100 1 ? 11 
HELX_P HELX_P4  AA4 GLY A 243 ? HIS A 278 ? GLY R 105 HIS R 140 1 ? 36 
HELX_P HELX_P5  AA5 SER A 282 ? LYS A 292 ? SER R 144 LYS R 154 1 ? 11 
HELX_P HELX_P6  AA6 LYS A 292 ? LEU A 305 ? LYS R 154 LEU R 167 1 ? 14 
HELX_P HELX_P7  AA7 THR A 306 ? PHE A 312 ? THR R 168 PHE R 174 1 ? 7  
HELX_P HELX_P8  AA8 ASN A 330 ? ILE A 347 ? ASN R 192 ILE R 209 1 ? 18 
HELX_P HELX_P9  AA9 ILE A 347 ? LYS A 365 ? ILE R 209 LYS R 227 1 ? 19 
HELX_P HELX_P10 AB1 SER A 373 ? LEU A 413 ? SER R 235 LEU R 275 1 ? 41 
HELX_P HELX_P11 AB2 GLY A 419 ? PHE A 438 ? GLY R 281 PHE R 300 1 ? 20 
HELX_P HELX_P12 AB3 PHE A 439 ? CYS A 441 ? PHE R 301 CYS R 303 5 ? 3  
HELX_P HELX_P13 AB4 CYS A 442 ? LEU A 451 ? CYS R 304 LEU R 313 1 ? 10 
HELX_P HELX_P14 AB5 LYS B 126 ? THR B 130 ? LYS N 88  THR N 92  5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 247 SG ? ? ? 1_555 A CYS 324 SG ? ? R CYS 109 R CYS 186 1_555 ? ? ? ? ? ? ? 2.032 ? ? 
disulf2 disulf ? ? B CYS 62  SG ? ? ? 1_555 B CYS 135 SG ? ? N CYS 24  N CYS 97  1_555 ? ? ? ? ? ? ? 2.031 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 247 ? CYS A 324 ? CYS R 109 ? 1_555 CYS R 186 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS B 62  ? CYS B 135 ? CYS N 24  ? 1_555 CYS N 97  ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 4 ? 
AA3 ? 5 ? 
AA4 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA4 1 2 ? parallel      
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 313 ? SER A 316 ? ALA R 175 SER R 178 
AA1 2 ILE A 323 ? ARG A 326 ? ILE R 185 ARG R 188 
AA2 1 VAL B 42  ? SER B 47  ? VAL N 4   SER N 9   
AA2 2 LEU B 58  ? GLY B 66  ? LEU N 20  GLY N 28  
AA2 3 THR B 117 ? MET B 122 ? THR N 79  MET N 84  
AA2 4 THR B 108 ? ASP B 112 ? THR N 70  ASP N 74  
AA3 1 GLY B 50  ? LEU B 51  ? GLY N 12  LEU N 13  
AA3 2 THR B 155 ? THR B 158 ? THR N 117 THR N 120 
AA3 3 VAL B 132 ? ARG B 140 ? VAL N 94  ARG N 102 
AA3 4 ARG B 70  ? ARG B 78  ? ARG N 32  ARG N 40  
AA3 5 GLU B 86  ? THR B 92  ? GLU N 48  THR N 54  
AA4 1 GLY B 50  ? LEU B 51  ? GLY N 12  LEU N 13  
AA4 2 THR B 155 ? THR B 158 ? THR N 117 THR N 120 
AA4 3 VAL B 132 ? ARG B 140 ? VAL N 94  ARG N 102 
AA4 4 LEU B 148 ? TRP B 151 ? LEU N 110 TRP N 113 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N SER A 316 ? N SER R 178 O ILE A 323 ? O ILE R 185 
AA2 1 2 N GLN B 43  ? N GLN N 5   O SER B 65  ? O SER N 27  
AA2 2 3 N LEU B 60  ? N LEU N 22  O LEU B 120 ? O LEU N 82  
AA2 3 4 O GLN B 121 ? O GLN N 83  N THR B 108 ? N THR N 70  
AA3 1 2 N GLY B 50  ? N GLY N 12  O THR B 158 ? O THR N 120 
AA3 2 3 O THR B 155 ? O THR N 117 N TYR B 133 ? N TYR N 95  
AA3 3 4 O ASN B 136 ? O ASN N 98  N GLY B 75  ? N GLY N 37  
AA3 4 5 N MET B 74  ? N MET N 36  O ILE B 91  ? O ILE N 53  
AA4 1 2 N GLY B 50  ? N GLY N 12  O THR B 158 ? O THR N 120 
AA4 2 3 O THR B 155 ? O THR N 117 N TYR B 133 ? N TYR N 95  
AA4 3 4 N ALA B 137 ? N ALA N 99  O GLY B 150 ? O GLY N 112 
# 
_pdbx_entry_details.entry_id                   8ZPM 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LYS R 68  ? ? -79.63  -165.68 
2 1 ASN R 101 ? ? -172.92 -179.84 
3 1 ASP R 182 ? ? 69.76   -5.58   
4 1 SER R 233 ? ? 57.57   -123.18 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8ZPM 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8ZPM 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.2 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               93558 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               'MULTIPLE SOURCES' 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 AMD070-CXCR4-KOR-Nb6 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2' 
# 
_em_imaging.entry_id                        8ZPM 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1500 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8ZPM 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8ZPM 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 R MET -137 ? A MET 1   
2   1 Y 1 R LYS -136 ? A LYS 2   
3   1 Y 1 R THR -135 ? A THR 3   
4   1 Y 1 R ILE -134 ? A ILE 4   
5   1 Y 1 R ILE -133 ? A ILE 5   
6   1 Y 1 R ALA -132 ? A ALA 6   
7   1 Y 1 R LEU -131 ? A LEU 7   
8   1 Y 1 R SER -130 ? A SER 8   
9   1 Y 1 R TYR -129 ? A TYR 9   
10  1 Y 1 R ILE -128 ? A ILE 10  
11  1 Y 1 R PHE -127 ? A PHE 11  
12  1 Y 1 R CYS -126 ? A CYS 12  
13  1 Y 1 R LEU -125 ? A LEU 13  
14  1 Y 1 R VAL -124 ? A VAL 14  
15  1 Y 1 R PHE -123 ? A PHE 15  
16  1 Y 1 R ALA -122 ? A ALA 16  
17  1 Y 1 R ASP -121 ? A ASP 17  
18  1 Y 1 R TYR -120 ? A TYR 18  
19  1 Y 1 R LYS -119 ? A LYS 19  
20  1 Y 1 R ASP -118 ? A ASP 20  
21  1 Y 1 R ASP -117 ? A ASP 21  
22  1 Y 1 R ASP -116 ? A ASP 22  
23  1 Y 1 R ASP -115 ? A ASP 23  
24  1 Y 1 R LYS -114 ? A LYS 24  
25  1 Y 1 R GLY -113 ? A GLY 25  
26  1 Y 1 R SER -112 ? A SER 26  
27  1 Y 1 R ALA -111 ? A ALA 27  
28  1 Y 1 R ASP -110 ? A ASP 28  
29  1 Y 1 R LEU -109 ? A LEU 29  
30  1 Y 1 R GLU -108 ? A GLU 30  
31  1 Y 1 R ASP -107 ? A ASP 31  
32  1 Y 1 R ASN -106 ? A ASN 32  
33  1 Y 1 R TRP -105 ? A TRP 33  
34  1 Y 1 R GLU -104 ? A GLU 34  
35  1 Y 1 R THR -103 ? A THR 35  
36  1 Y 1 R LEU -102 ? A LEU 36  
37  1 Y 1 R ASN -101 ? A ASN 37  
38  1 Y 1 R ASP -100 ? A ASP 38  
39  1 Y 1 R ASN -99  ? A ASN 39  
40  1 Y 1 R LEU -98  ? A LEU 40  
41  1 Y 1 R LYS -97  ? A LYS 41  
42  1 Y 1 R VAL -96  ? A VAL 42  
43  1 Y 1 R ILE -95  ? A ILE 43  
44  1 Y 1 R GLU -94  ? A GLU 44  
45  1 Y 1 R LYS -93  ? A LYS 45  
46  1 Y 1 R ALA -92  ? A ALA 46  
47  1 Y 1 R ASP -91  ? A ASP 47  
48  1 Y 1 R ASN -90  ? A ASN 48  
49  1 Y 1 R ALA -89  ? A ALA 49  
50  1 Y 1 R ALA -88  ? A ALA 50  
51  1 Y 1 R GLN -87  ? A GLN 51  
52  1 Y 1 R VAL -86  ? A VAL 52  
53  1 Y 1 R LYS -85  ? A LYS 53  
54  1 Y 1 R ASP -84  ? A ASP 54  
55  1 Y 1 R ALA -83  ? A ALA 55  
56  1 Y 1 R LEU -82  ? A LEU 56  
57  1 Y 1 R THR -81  ? A THR 57  
58  1 Y 1 R LYS -80  ? A LYS 58  
59  1 Y 1 R MET -79  ? A MET 59  
60  1 Y 1 R ARG -78  ? A ARG 60  
61  1 Y 1 R ALA -77  ? A ALA 61  
62  1 Y 1 R ALA -76  ? A ALA 62  
63  1 Y 1 R ALA -75  ? A ALA 63  
64  1 Y 1 R LEU -74  ? A LEU 64  
65  1 Y 1 R ASP -73  ? A ASP 65  
66  1 Y 1 R ALA -72  ? A ALA 66  
67  1 Y 1 R GLN -71  ? A GLN 67  
68  1 Y 1 R LYS -70  ? A LYS 68  
69  1 Y 1 R ALA -69  ? A ALA 69  
70  1 Y 1 R THR -68  ? A THR 70  
71  1 Y 1 R PRO -67  ? A PRO 71  
72  1 Y 1 R PRO -66  ? A PRO 72  
73  1 Y 1 R LYS -65  ? A LYS 73  
74  1 Y 1 R LEU -64  ? A LEU 74  
75  1 Y 1 R GLU -63  ? A GLU 75  
76  1 Y 1 R ASP -62  ? A ASP 76  
77  1 Y 1 R LYS -61  ? A LYS 77  
78  1 Y 1 R SER -60  ? A SER 78  
79  1 Y 1 R PRO -59  ? A PRO 79  
80  1 Y 1 R ASP -58  ? A ASP 80  
81  1 Y 1 R SER -57  ? A SER 81  
82  1 Y 1 R PRO -56  ? A PRO 82  
83  1 Y 1 R GLU -55  ? A GLU 83  
84  1 Y 1 R MET -54  ? A MET 84  
85  1 Y 1 R LYS -53  ? A LYS 85  
86  1 Y 1 R ASP -52  ? A ASP 86  
87  1 Y 1 R PHE -51  ? A PHE 87  
88  1 Y 1 R ARG -50  ? A ARG 88  
89  1 Y 1 R HIS -49  ? A HIS 89  
90  1 Y 1 R GLY -48  ? A GLY 90  
91  1 Y 1 R PHE -47  ? A PHE 91  
92  1 Y 1 R ASP -46  ? A ASP 92  
93  1 Y 1 R ILE -45  ? A ILE 93  
94  1 Y 1 R LEU -44  ? A LEU 94  
95  1 Y 1 R VAL -43  ? A VAL 95  
96  1 Y 1 R GLY -42  ? A GLY 96  
97  1 Y 1 R GLN -41  ? A GLN 97  
98  1 Y 1 R ILE -40  ? A ILE 98  
99  1 Y 1 R ASP -39  ? A ASP 99  
100 1 Y 1 R ASP -38  ? A ASP 100 
101 1 Y 1 R ALA -37  ? A ALA 101 
102 1 Y 1 R LEU -36  ? A LEU 102 
103 1 Y 1 R LYS -35  ? A LYS 103 
104 1 Y 1 R LEU -34  ? A LEU 104 
105 1 Y 1 R ALA -33  ? A ALA 105 
106 1 Y 1 R ASN -32  ? A ASN 106 
107 1 Y 1 R GLU -31  ? A GLU 107 
108 1 Y 1 R GLY -30  ? A GLY 108 
109 1 Y 1 R LYS -29  ? A LYS 109 
110 1 Y 1 R VAL -28  ? A VAL 110 
111 1 Y 1 R LYS -27  ? A LYS 111 
112 1 Y 1 R GLU -26  ? A GLU 112 
113 1 Y 1 R ALA -25  ? A ALA 113 
114 1 Y 1 R GLN -24  ? A GLN 114 
115 1 Y 1 R ALA -23  ? A ALA 115 
116 1 Y 1 R ALA -22  ? A ALA 116 
117 1 Y 1 R ALA -21  ? A ALA 117 
118 1 Y 1 R GLU -20  ? A GLU 118 
119 1 Y 1 R GLN -19  ? A GLN 119 
120 1 Y 1 R LEU -18  ? A LEU 120 
121 1 Y 1 R LYS -17  ? A LYS 121 
122 1 Y 1 R THR -16  ? A THR 122 
123 1 Y 1 R THR -15  ? A THR 123 
124 1 Y 1 R ARG -14  ? A ARG 124 
125 1 Y 1 R ASN -13  ? A ASN 125 
126 1 Y 1 R ALA -12  ? A ALA 126 
127 1 Y 1 R TYR -11  ? A TYR 127 
128 1 Y 1 R ILE -10  ? A ILE 128 
129 1 Y 1 R GLN -9   ? A GLN 129 
130 1 Y 1 R LYS -8   ? A LYS 130 
131 1 Y 1 R TYR -7   ? A TYR 131 
132 1 Y 1 R LEU -6   ? A LEU 132 
133 1 Y 1 R LEU -5   ? A LEU 133 
134 1 Y 1 R VAL -4   ? A VAL 134 
135 1 Y 1 R PRO -3   ? A PRO 135 
136 1 Y 1 R ARG -2   ? A ARG 136 
137 1 Y 1 R GLY -1   ? A GLY 137 
138 1 Y 1 R SER 0    ? A SER 138 
139 1 Y 1 R MET 1    ? A MET 139 
140 1 Y 1 R GLU 2    ? A GLU 140 
141 1 Y 1 R GLY 3    ? A GLY 141 
142 1 Y 1 R ILE 4    ? A ILE 142 
143 1 Y 1 R SER 5    ? A SER 143 
144 1 Y 1 R ILE 6    ? A ILE 144 
145 1 Y 1 R TYR 7    ? A TYR 145 
146 1 Y 1 R THR 8    ? A THR 146 
147 1 Y 1 R SER 9    ? A SER 147 
148 1 Y 1 R ASP 10   ? A ASP 148 
149 1 Y 1 R ASN 11   ? A ASN 149 
150 1 Y 1 R TYR 12   ? A TYR 150 
151 1 Y 1 R THR 13   ? A THR 151 
152 1 Y 1 R GLU 14   ? A GLU 152 
153 1 Y 1 R GLU 15   ? A GLU 153 
154 1 Y 1 R MET 16   ? A MET 154 
155 1 Y 1 R GLY 17   ? A GLY 155 
156 1 Y 1 R SER 18   ? A SER 156 
157 1 Y 1 R GLY 19   ? A GLY 157 
158 1 Y 1 R ASP 20   ? A ASP 158 
159 1 Y 1 R TYR 21   ? A TYR 159 
160 1 Y 1 R ASP 22   ? A ASP 160 
161 1 Y 1 R SER 23   ? A SER 161 
162 1 Y 1 R MET 24   ? A MET 162 
163 1 Y 1 R LYS 25   ? A LYS 163 
164 1 Y 1 R GLU 26   ? A GLU 164 
165 1 Y 1 R PRO 27   ? A PRO 165 
166 1 Y 1 R CYS 28   ? A CYS 166 
167 1 Y 1 R PHE 29   ? A PHE 167 
168 1 Y 1 R ARG 30   ? A ARG 168 
169 1 Y 1 R GLU 31   ? A GLU 169 
170 1 Y 1 R GLU 32   ? A GLU 170 
171 1 Y 1 R ASN 33   ? A ASN 171 
172 1 Y 1 R LYS 316  ? A LYS 454 
173 1 Y 1 R PHE 317  ? A PHE 455 
174 1 Y 1 R LYS 318  ? A LYS 456 
175 1 Y 1 R THR 319  ? A THR 457 
176 1 Y 1 R SER 320  ? A SER 458 
177 1 Y 1 R ALA 321  ? A ALA 459 
178 1 Y 1 R GLN 322  ? A GLN 460 
179 1 Y 1 R HIS 323  ? A HIS 461 
180 1 Y 1 R ALA 324  ? A ALA 462 
181 1 Y 1 R LEU 325  ? A LEU 463 
182 1 Y 1 R THR 326  ? A THR 464 
183 1 Y 1 R SER 327  ? A SER 465 
184 1 Y 1 R GLY 328  ? A GLY 466 
185 1 Y 1 R ARG 329  ? A ARG 467 
186 1 Y 1 R PRO 330  ? A PRO 468 
187 1 Y 1 R LEU 331  ? A LEU 469 
188 1 Y 1 R GLU 332  ? A GLU 470 
189 1 Y 1 R VAL 333  ? A VAL 471 
190 1 Y 1 R LEU 334  ? A LEU 472 
191 1 Y 1 R PHE 335  ? A PHE 473 
192 1 Y 1 R GLN 336  ? A GLN 474 
193 1 Y 1 R GLY 337  ? A GLY 475 
194 1 Y 1 R PRO 338  ? A PRO 476 
195 1 Y 1 R HIS 339  ? A HIS 477 
196 1 Y 1 R HIS 340  ? A HIS 478 
197 1 Y 1 R HIS 341  ? A HIS 479 
198 1 Y 1 R HIS 342  ? A HIS 480 
199 1 Y 1 R HIS 343  ? A HIS 481 
200 1 Y 1 R HIS 344  ? A HIS 482 
201 1 Y 1 R HIS 345  ? A HIS 483 
202 1 Y 1 R HIS 346  ? A HIS 484 
203 1 Y 1 R HIS 347  ? A HIS 485 
204 1 Y 1 R HIS 348  ? A HIS 486 
205 1 Y 1 N MET -37  ? B MET 1   
206 1 Y 1 N LEU -36  ? B LEU 2   
207 1 Y 1 N LEU -35  ? B LEU 3   
208 1 Y 1 N VAL -34  ? B VAL 4   
209 1 Y 1 N ASN -33  ? B ASN 5   
210 1 Y 1 N GLN -32  ? B GLN 6   
211 1 Y 1 N SER -31  ? B SER 7   
212 1 Y 1 N HIS -30  ? B HIS 8   
213 1 Y 1 N GLN -29  ? B GLN 9   
214 1 Y 1 N GLY -28  ? B GLY 10  
215 1 Y 1 N PHE -27  ? B PHE 11  
216 1 Y 1 N ASN -26  ? B ASN 12  
217 1 Y 1 N LYS -25  ? B LYS 13  
218 1 Y 1 N GLU -24  ? B GLU 14  
219 1 Y 1 N HIS -23  ? B HIS 15  
220 1 Y 1 N THR -22  ? B THR 16  
221 1 Y 1 N SER -21  ? B SER 17  
222 1 Y 1 N LYS -20  ? B LYS 18  
223 1 Y 1 N MET -19  ? B MET 19  
224 1 Y 1 N VAL -18  ? B VAL 20  
225 1 Y 1 N SER -17  ? B SER 21  
226 1 Y 1 N ALA -16  ? B ALA 22  
227 1 Y 1 N ILE -15  ? B ILE 23  
228 1 Y 1 N VAL -14  ? B VAL 24  
229 1 Y 1 N LEU -13  ? B LEU 25  
230 1 Y 1 N TYR -12  ? B TYR 26  
231 1 Y 1 N VAL -11  ? B VAL 27  
232 1 Y 1 N LEU -10  ? B LEU 28  
233 1 Y 1 N LEU -9   ? B LEU 29  
234 1 Y 1 N ALA -8   ? B ALA 30  
235 1 Y 1 N ALA -7   ? B ALA 31  
236 1 Y 1 N ALA -6   ? B ALA 32  
237 1 Y 1 N ALA -5   ? B ALA 33  
238 1 Y 1 N HIS -4   ? B HIS 34  
239 1 Y 1 N SER -3   ? B SER 35  
240 1 Y 1 N ALA -2   ? B ALA 36  
241 1 Y 1 N PHE -1   ? B PHE 37  
242 1 Y 1 N ALA 0    ? B ALA 38  
243 1 Y 1 N MET 1    ? B MET 39  
244 1 Y 1 N ALA 2    ? B ALA 40  
245 1 Y 1 N ARG 41   ? B ARG 79  
246 1 Y 1 N VAL 42   ? B VAL 80  
247 1 Y 1 N SER 43   ? B SER 81  
248 1 Y 1 N GLY 44   ? B GLY 82  
249 1 Y 1 N ASN 45   ? B ASN 83  
250 1 Y 1 N HIS 124  ? B HIS 162 
251 1 Y 1 N HIS 125  ? B HIS 163 
252 1 Y 1 N HIS 126  ? B HIS 164 
253 1 Y 1 N HIS 127  ? B HIS 165 
254 1 Y 1 N HIS 128  ? B HIS 166 
255 1 Y 1 N HIS 129  ? B HIS 167 
256 1 Y 1 N HIS 130  ? B HIS 168 
257 1 Y 1 N HIS 131  ? B HIS 169 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1D8L C14  C N N 1   
A1D8L C15  C Y N 2   
A1D8L C16  C Y N 3   
A1D8L C17  C Y N 4   
A1D8L C18  C Y N 5   
A1D8L C19  C Y N 6   
A1D8L C20  C Y N 7   
A1D8L C21  C Y N 8   
A1D8L N2   N N N 9   
A1D8L C1   C N N 10  
A1D8L C10  C N N 11  
A1D8L C11  C N N 12  
A1D8L C12  C N N 13  
A1D8L C13  C N N 14  
A1D8L C2   C N N 15  
A1D8L C3   C N S 16  
A1D8L C4   C Y N 17  
A1D8L C5   C Y N 18  
A1D8L C6   C N N 19  
A1D8L C7   C Y N 20  
A1D8L C8   C Y N 21  
A1D8L C9   C Y N 22  
A1D8L N1   N Y N 23  
A1D8L N3   N N N 24  
A1D8L N4   N Y N 25  
A1D8L N5   N Y N 26  
A1D8L H1   H N N 27  
A1D8L H2   H N N 28  
A1D8L H3   H N N 29  
A1D8L H4   H N N 30  
A1D8L H5   H N N 31  
A1D8L H6   H N N 32  
A1D8L H8   H N N 33  
A1D8L H9   H N N 34  
A1D8L H10  H N N 35  
A1D8L H11  H N N 36  
A1D8L H12  H N N 37  
A1D8L H13  H N N 38  
A1D8L H14  H N N 39  
A1D8L H15  H N N 40  
A1D8L H16  H N N 41  
A1D8L H17  H N N 42  
A1D8L H18  H N N 43  
A1D8L H19  H N N 44  
A1D8L H20  H N N 45  
A1D8L H21  H N N 46  
A1D8L H22  H N N 47  
A1D8L H23  H N N 48  
A1D8L H24  H N N 49  
A1D8L H25  H N N 50  
A1D8L H26  H N N 51  
A1D8L H27  H N N 52  
A1D8L H30  H N N 53  
ALA   N    N N N 54  
ALA   CA   C N S 55  
ALA   C    C N N 56  
ALA   O    O N N 57  
ALA   CB   C N N 58  
ALA   OXT  O N N 59  
ALA   H    H N N 60  
ALA   H2   H N N 61  
ALA   HA   H N N 62  
ALA   HB1  H N N 63  
ALA   HB2  H N N 64  
ALA   HB3  H N N 65  
ALA   HXT  H N N 66  
ARG   N    N N N 67  
ARG   CA   C N S 68  
ARG   C    C N N 69  
ARG   O    O N N 70  
ARG   CB   C N N 71  
ARG   CG   C N N 72  
ARG   CD   C N N 73  
ARG   NE   N N N 74  
ARG   CZ   C N N 75  
ARG   NH1  N N N 76  
ARG   NH2  N N N 77  
ARG   OXT  O N N 78  
ARG   H    H N N 79  
ARG   H2   H N N 80  
ARG   HA   H N N 81  
ARG   HB2  H N N 82  
ARG   HB3  H N N 83  
ARG   HG2  H N N 84  
ARG   HG3  H N N 85  
ARG   HD2  H N N 86  
ARG   HD3  H N N 87  
ARG   HE   H N N 88  
ARG   HH11 H N N 89  
ARG   HH12 H N N 90  
ARG   HH21 H N N 91  
ARG   HH22 H N N 92  
ARG   HXT  H N N 93  
ASN   N    N N N 94  
ASN   CA   C N S 95  
ASN   C    C N N 96  
ASN   O    O N N 97  
ASN   CB   C N N 98  
ASN   CG   C N N 99  
ASN   OD1  O N N 100 
ASN   ND2  N N N 101 
ASN   OXT  O N N 102 
ASN   H    H N N 103 
ASN   H2   H N N 104 
ASN   HA   H N N 105 
ASN   HB2  H N N 106 
ASN   HB3  H N N 107 
ASN   HD21 H N N 108 
ASN   HD22 H N N 109 
ASN   HXT  H N N 110 
ASP   N    N N N 111 
ASP   CA   C N S 112 
ASP   C    C N N 113 
ASP   O    O N N 114 
ASP   CB   C N N 115 
ASP   CG   C N N 116 
ASP   OD1  O N N 117 
ASP   OD2  O N N 118 
ASP   OXT  O N N 119 
ASP   H    H N N 120 
ASP   H2   H N N 121 
ASP   HA   H N N 122 
ASP   HB2  H N N 123 
ASP   HB3  H N N 124 
ASP   HD2  H N N 125 
ASP   HXT  H N N 126 
CLR   C1   C N N 127 
CLR   C2   C N N 128 
CLR   C3   C N S 129 
CLR   C4   C N N 130 
CLR   C5   C N N 131 
CLR   C6   C N N 132 
CLR   C7   C N N 133 
CLR   C8   C N S 134 
CLR   C9   C N S 135 
CLR   C10  C N R 136 
CLR   C11  C N N 137 
CLR   C12  C N N 138 
CLR   C13  C N R 139 
CLR   C14  C N S 140 
CLR   C15  C N N 141 
CLR   C16  C N N 142 
CLR   C17  C N R 143 
CLR   C18  C N N 144 
CLR   C19  C N N 145 
CLR   C20  C N R 146 
CLR   C21  C N N 147 
CLR   C22  C N N 148 
CLR   C23  C N N 149 
CLR   C24  C N N 150 
CLR   C25  C N N 151 
CLR   C26  C N N 152 
CLR   C27  C N N 153 
CLR   O1   O N N 154 
CLR   H11  H N N 155 
CLR   H12  H N N 156 
CLR   H21  H N N 157 
CLR   H22  H N N 158 
CLR   H3   H N N 159 
CLR   H41  H N N 160 
CLR   H42  H N N 161 
CLR   H6   H N N 162 
CLR   H71  H N N 163 
CLR   H72  H N N 164 
CLR   H8   H N N 165 
CLR   H9   H N N 166 
CLR   H111 H N N 167 
CLR   H112 H N N 168 
CLR   H121 H N N 169 
CLR   H122 H N N 170 
CLR   H14  H N N 171 
CLR   H151 H N N 172 
CLR   H152 H N N 173 
CLR   H161 H N N 174 
CLR   H162 H N N 175 
CLR   H17  H N N 176 
CLR   H181 H N N 177 
CLR   H182 H N N 178 
CLR   H183 H N N 179 
CLR   H191 H N N 180 
CLR   H192 H N N 181 
CLR   H193 H N N 182 
CLR   H20  H N N 183 
CLR   H211 H N N 184 
CLR   H212 H N N 185 
CLR   H213 H N N 186 
CLR   H221 H N N 187 
CLR   H222 H N N 188 
CLR   H231 H N N 189 
CLR   H232 H N N 190 
CLR   H241 H N N 191 
CLR   H242 H N N 192 
CLR   H25  H N N 193 
CLR   H261 H N N 194 
CLR   H262 H N N 195 
CLR   H263 H N N 196 
CLR   H271 H N N 197 
CLR   H272 H N N 198 
CLR   H273 H N N 199 
CLR   H1   H N N 200 
CYS   N    N N N 201 
CYS   CA   C N R 202 
CYS   C    C N N 203 
CYS   O    O N N 204 
CYS   CB   C N N 205 
CYS   SG   S N N 206 
CYS   OXT  O N N 207 
CYS   H    H N N 208 
CYS   H2   H N N 209 
CYS   HA   H N N 210 
CYS   HB2  H N N 211 
CYS   HB3  H N N 212 
CYS   HG   H N N 213 
CYS   HXT  H N N 214 
GLN   N    N N N 215 
GLN   CA   C N S 216 
GLN   C    C N N 217 
GLN   O    O N N 218 
GLN   CB   C N N 219 
GLN   CG   C N N 220 
GLN   CD   C N N 221 
GLN   OE1  O N N 222 
GLN   NE2  N N N 223 
GLN   OXT  O N N 224 
GLN   H    H N N 225 
GLN   H2   H N N 226 
GLN   HA   H N N 227 
GLN   HB2  H N N 228 
GLN   HB3  H N N 229 
GLN   HG2  H N N 230 
GLN   HG3  H N N 231 
GLN   HE21 H N N 232 
GLN   HE22 H N N 233 
GLN   HXT  H N N 234 
GLU   N    N N N 235 
GLU   CA   C N S 236 
GLU   C    C N N 237 
GLU   O    O N N 238 
GLU   CB   C N N 239 
GLU   CG   C N N 240 
GLU   CD   C N N 241 
GLU   OE1  O N N 242 
GLU   OE2  O N N 243 
GLU   OXT  O N N 244 
GLU   H    H N N 245 
GLU   H2   H N N 246 
GLU   HA   H N N 247 
GLU   HB2  H N N 248 
GLU   HB3  H N N 249 
GLU   HG2  H N N 250 
GLU   HG3  H N N 251 
GLU   HE2  H N N 252 
GLU   HXT  H N N 253 
GLY   N    N N N 254 
GLY   CA   C N N 255 
GLY   C    C N N 256 
GLY   O    O N N 257 
GLY   OXT  O N N 258 
GLY   H    H N N 259 
GLY   H2   H N N 260 
GLY   HA2  H N N 261 
GLY   HA3  H N N 262 
GLY   HXT  H N N 263 
HIS   N    N N N 264 
HIS   CA   C N S 265 
HIS   C    C N N 266 
HIS   O    O N N 267 
HIS   CB   C N N 268 
HIS   CG   C Y N 269 
HIS   ND1  N Y N 270 
HIS   CD2  C Y N 271 
HIS   CE1  C Y N 272 
HIS   NE2  N Y N 273 
HIS   OXT  O N N 274 
HIS   H    H N N 275 
HIS   H2   H N N 276 
HIS   HA   H N N 277 
HIS   HB2  H N N 278 
HIS   HB3  H N N 279 
HIS   HD1  H N N 280 
HIS   HD2  H N N 281 
HIS   HE1  H N N 282 
HIS   HE2  H N N 283 
HIS   HXT  H N N 284 
ILE   N    N N N 285 
ILE   CA   C N S 286 
ILE   C    C N N 287 
ILE   O    O N N 288 
ILE   CB   C N S 289 
ILE   CG1  C N N 290 
ILE   CG2  C N N 291 
ILE   CD1  C N N 292 
ILE   OXT  O N N 293 
ILE   H    H N N 294 
ILE   H2   H N N 295 
ILE   HA   H N N 296 
ILE   HB   H N N 297 
ILE   HG12 H N N 298 
ILE   HG13 H N N 299 
ILE   HG21 H N N 300 
ILE   HG22 H N N 301 
ILE   HG23 H N N 302 
ILE   HD11 H N N 303 
ILE   HD12 H N N 304 
ILE   HD13 H N N 305 
ILE   HXT  H N N 306 
LEU   N    N N N 307 
LEU   CA   C N S 308 
LEU   C    C N N 309 
LEU   O    O N N 310 
LEU   CB   C N N 311 
LEU   CG   C N N 312 
LEU   CD1  C N N 313 
LEU   CD2  C N N 314 
LEU   OXT  O N N 315 
LEU   H    H N N 316 
LEU   H2   H N N 317 
LEU   HA   H N N 318 
LEU   HB2  H N N 319 
LEU   HB3  H N N 320 
LEU   HG   H N N 321 
LEU   HD11 H N N 322 
LEU   HD12 H N N 323 
LEU   HD13 H N N 324 
LEU   HD21 H N N 325 
LEU   HD22 H N N 326 
LEU   HD23 H N N 327 
LEU   HXT  H N N 328 
LYS   N    N N N 329 
LYS   CA   C N S 330 
LYS   C    C N N 331 
LYS   O    O N N 332 
LYS   CB   C N N 333 
LYS   CG   C N N 334 
LYS   CD   C N N 335 
LYS   CE   C N N 336 
LYS   NZ   N N N 337 
LYS   OXT  O N N 338 
LYS   H    H N N 339 
LYS   H2   H N N 340 
LYS   HA   H N N 341 
LYS   HB2  H N N 342 
LYS   HB3  H N N 343 
LYS   HG2  H N N 344 
LYS   HG3  H N N 345 
LYS   HD2  H N N 346 
LYS   HD3  H N N 347 
LYS   HE2  H N N 348 
LYS   HE3  H N N 349 
LYS   HZ1  H N N 350 
LYS   HZ2  H N N 351 
LYS   HZ3  H N N 352 
LYS   HXT  H N N 353 
MET   N    N N N 354 
MET   CA   C N S 355 
MET   C    C N N 356 
MET   O    O N N 357 
MET   CB   C N N 358 
MET   CG   C N N 359 
MET   SD   S N N 360 
MET   CE   C N N 361 
MET   OXT  O N N 362 
MET   H    H N N 363 
MET   H2   H N N 364 
MET   HA   H N N 365 
MET   HB2  H N N 366 
MET   HB3  H N N 367 
MET   HG2  H N N 368 
MET   HG3  H N N 369 
MET   HE1  H N N 370 
MET   HE2  H N N 371 
MET   HE3  H N N 372 
MET   HXT  H N N 373 
PHE   N    N N N 374 
PHE   CA   C N S 375 
PHE   C    C N N 376 
PHE   O    O N N 377 
PHE   CB   C N N 378 
PHE   CG   C Y N 379 
PHE   CD1  C Y N 380 
PHE   CD2  C Y N 381 
PHE   CE1  C Y N 382 
PHE   CE2  C Y N 383 
PHE   CZ   C Y N 384 
PHE   OXT  O N N 385 
PHE   H    H N N 386 
PHE   H2   H N N 387 
PHE   HA   H N N 388 
PHE   HB2  H N N 389 
PHE   HB3  H N N 390 
PHE   HD1  H N N 391 
PHE   HD2  H N N 392 
PHE   HE1  H N N 393 
PHE   HE2  H N N 394 
PHE   HZ   H N N 395 
PHE   HXT  H N N 396 
PRO   N    N N N 397 
PRO   CA   C N S 398 
PRO   C    C N N 399 
PRO   O    O N N 400 
PRO   CB   C N N 401 
PRO   CG   C N N 402 
PRO   CD   C N N 403 
PRO   OXT  O N N 404 
PRO   H    H N N 405 
PRO   HA   H N N 406 
PRO   HB2  H N N 407 
PRO   HB3  H N N 408 
PRO   HG2  H N N 409 
PRO   HG3  H N N 410 
PRO   HD2  H N N 411 
PRO   HD3  H N N 412 
PRO   HXT  H N N 413 
SER   N    N N N 414 
SER   CA   C N S 415 
SER   C    C N N 416 
SER   O    O N N 417 
SER   CB   C N N 418 
SER   OG   O N N 419 
SER   OXT  O N N 420 
SER   H    H N N 421 
SER   H2   H N N 422 
SER   HA   H N N 423 
SER   HB2  H N N 424 
SER   HB3  H N N 425 
SER   HG   H N N 426 
SER   HXT  H N N 427 
THR   N    N N N 428 
THR   CA   C N S 429 
THR   C    C N N 430 
THR   O    O N N 431 
THR   CB   C N R 432 
THR   OG1  O N N 433 
THR   CG2  C N N 434 
THR   OXT  O N N 435 
THR   H    H N N 436 
THR   H2   H N N 437 
THR   HA   H N N 438 
THR   HB   H N N 439 
THR   HG1  H N N 440 
THR   HG21 H N N 441 
THR   HG22 H N N 442 
THR   HG23 H N N 443 
THR   HXT  H N N 444 
TRP   N    N N N 445 
TRP   CA   C N S 446 
TRP   C    C N N 447 
TRP   O    O N N 448 
TRP   CB   C N N 449 
TRP   CG   C Y N 450 
TRP   CD1  C Y N 451 
TRP   CD2  C Y N 452 
TRP   NE1  N Y N 453 
TRP   CE2  C Y N 454 
TRP   CE3  C Y N 455 
TRP   CZ2  C Y N 456 
TRP   CZ3  C Y N 457 
TRP   CH2  C Y N 458 
TRP   OXT  O N N 459 
TRP   H    H N N 460 
TRP   H2   H N N 461 
TRP   HA   H N N 462 
TRP   HB2  H N N 463 
TRP   HB3  H N N 464 
TRP   HD1  H N N 465 
TRP   HE1  H N N 466 
TRP   HE3  H N N 467 
TRP   HZ2  H N N 468 
TRP   HZ3  H N N 469 
TRP   HH2  H N N 470 
TRP   HXT  H N N 471 
TYR   N    N N N 472 
TYR   CA   C N S 473 
TYR   C    C N N 474 
TYR   O    O N N 475 
TYR   CB   C N N 476 
TYR   CG   C Y N 477 
TYR   CD1  C Y N 478 
TYR   CD2  C Y N 479 
TYR   CE1  C Y N 480 
TYR   CE2  C Y N 481 
TYR   CZ   C Y N 482 
TYR   OH   O N N 483 
TYR   OXT  O N N 484 
TYR   H    H N N 485 
TYR   H2   H N N 486 
TYR   HA   H N N 487 
TYR   HB2  H N N 488 
TYR   HB3  H N N 489 
TYR   HD1  H N N 490 
TYR   HD2  H N N 491 
TYR   HE1  H N N 492 
TYR   HE2  H N N 493 
TYR   HH   H N N 494 
TYR   HXT  H N N 495 
VAL   N    N N N 496 
VAL   CA   C N S 497 
VAL   C    C N N 498 
VAL   O    O N N 499 
VAL   CB   C N N 500 
VAL   CG1  C N N 501 
VAL   CG2  C N N 502 
VAL   OXT  O N N 503 
VAL   H    H N N 504 
VAL   H2   H N N 505 
VAL   HA   H N N 506 
VAL   HB   H N N 507 
VAL   HG11 H N N 508 
VAL   HG12 H N N 509 
VAL   HG13 H N N 510 
VAL   HG21 H N N 511 
VAL   HG22 H N N 512 
VAL   HG23 H N N 513 
VAL   HXT  H N N 514 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1D8L N3  C13  sing N N 1   
A1D8L C13 C12  sing N N 2   
A1D8L C12 C11  sing N N 3   
A1D8L C11 C10  sing N N 4   
A1D8L C10 N2   sing N N 5   
A1D8L C2  C1   sing N N 6   
A1D8L C2  C3   sing N N 7   
A1D8L N2  C14  sing N N 8   
A1D8L N2  C3   sing N N 9   
A1D8L C1  C6   sing N N 10  
A1D8L C14 C15  sing N N 11  
A1D8L C6  C5   sing N N 12  
A1D8L C5  C7   doub Y N 13  
A1D8L C5  C4   sing Y N 14  
A1D8L C7  C8   sing Y N 15  
A1D8L C8  C9   doub Y N 16  
A1D8L C3  C4   sing N N 17  
A1D8L C4  N1   doub Y N 18  
A1D8L C9  N1   sing Y N 19  
A1D8L N4  C15  doub Y N 20  
A1D8L N4  C16  sing Y N 21  
A1D8L C15 N5   sing Y N 22  
A1D8L C16 C17  doub Y N 23  
A1D8L C16 C21  sing Y N 24  
A1D8L N5  C21  sing Y N 25  
A1D8L C17 C18  sing Y N 26  
A1D8L C21 C20  doub Y N 27  
A1D8L C18 C19  doub Y N 28  
A1D8L C20 C19  sing Y N 29  
A1D8L C14 H1   sing N N 30  
A1D8L C14 H2   sing N N 31  
A1D8L C17 H3   sing N N 32  
A1D8L C18 H4   sing N N 33  
A1D8L C19 H5   sing N N 34  
A1D8L C20 H6   sing N N 35  
A1D8L C1  H8   sing N N 36  
A1D8L C1  H9   sing N N 37  
A1D8L C10 H10  sing N N 38  
A1D8L C10 H11  sing N N 39  
A1D8L C11 H12  sing N N 40  
A1D8L C11 H13  sing N N 41  
A1D8L C12 H14  sing N N 42  
A1D8L C12 H15  sing N N 43  
A1D8L C13 H16  sing N N 44  
A1D8L C13 H17  sing N N 45  
A1D8L C2  H18  sing N N 46  
A1D8L C2  H19  sing N N 47  
A1D8L C3  H20  sing N N 48  
A1D8L C6  H21  sing N N 49  
A1D8L C6  H22  sing N N 50  
A1D8L C7  H23  sing N N 51  
A1D8L C8  H24  sing N N 52  
A1D8L C9  H25  sing N N 53  
A1D8L N3  H26  sing N N 54  
A1D8L N3  H27  sing N N 55  
A1D8L N5  H30  sing N N 56  
ALA   N   CA   sing N N 57  
ALA   N   H    sing N N 58  
ALA   N   H2   sing N N 59  
ALA   CA  C    sing N N 60  
ALA   CA  CB   sing N N 61  
ALA   CA  HA   sing N N 62  
ALA   C   O    doub N N 63  
ALA   C   OXT  sing N N 64  
ALA   CB  HB1  sing N N 65  
ALA   CB  HB2  sing N N 66  
ALA   CB  HB3  sing N N 67  
ALA   OXT HXT  sing N N 68  
ARG   N   CA   sing N N 69  
ARG   N   H    sing N N 70  
ARG   N   H2   sing N N 71  
ARG   CA  C    sing N N 72  
ARG   CA  CB   sing N N 73  
ARG   CA  HA   sing N N 74  
ARG   C   O    doub N N 75  
ARG   C   OXT  sing N N 76  
ARG   CB  CG   sing N N 77  
ARG   CB  HB2  sing N N 78  
ARG   CB  HB3  sing N N 79  
ARG   CG  CD   sing N N 80  
ARG   CG  HG2  sing N N 81  
ARG   CG  HG3  sing N N 82  
ARG   CD  NE   sing N N 83  
ARG   CD  HD2  sing N N 84  
ARG   CD  HD3  sing N N 85  
ARG   NE  CZ   sing N N 86  
ARG   NE  HE   sing N N 87  
ARG   CZ  NH1  sing N N 88  
ARG   CZ  NH2  doub N N 89  
ARG   NH1 HH11 sing N N 90  
ARG   NH1 HH12 sing N N 91  
ARG   NH2 HH21 sing N N 92  
ARG   NH2 HH22 sing N N 93  
ARG   OXT HXT  sing N N 94  
ASN   N   CA   sing N N 95  
ASN   N   H    sing N N 96  
ASN   N   H2   sing N N 97  
ASN   CA  C    sing N N 98  
ASN   CA  CB   sing N N 99  
ASN   CA  HA   sing N N 100 
ASN   C   O    doub N N 101 
ASN   C   OXT  sing N N 102 
ASN   CB  CG   sing N N 103 
ASN   CB  HB2  sing N N 104 
ASN   CB  HB3  sing N N 105 
ASN   CG  OD1  doub N N 106 
ASN   CG  ND2  sing N N 107 
ASN   ND2 HD21 sing N N 108 
ASN   ND2 HD22 sing N N 109 
ASN   OXT HXT  sing N N 110 
ASP   N   CA   sing N N 111 
ASP   N   H    sing N N 112 
ASP   N   H2   sing N N 113 
ASP   CA  C    sing N N 114 
ASP   CA  CB   sing N N 115 
ASP   CA  HA   sing N N 116 
ASP   C   O    doub N N 117 
ASP   C   OXT  sing N N 118 
ASP   CB  CG   sing N N 119 
ASP   CB  HB2  sing N N 120 
ASP   CB  HB3  sing N N 121 
ASP   CG  OD1  doub N N 122 
ASP   CG  OD2  sing N N 123 
ASP   OD2 HD2  sing N N 124 
ASP   OXT HXT  sing N N 125 
CLR   C1  C2   sing N N 126 
CLR   C1  C10  sing N N 127 
CLR   C1  H11  sing N N 128 
CLR   C1  H12  sing N N 129 
CLR   C2  C3   sing N N 130 
CLR   C2  H21  sing N N 131 
CLR   C2  H22  sing N N 132 
CLR   C3  C4   sing N N 133 
CLR   C3  O1   sing N N 134 
CLR   C3  H3   sing N N 135 
CLR   C4  C5   sing N N 136 
CLR   C4  H41  sing N N 137 
CLR   C4  H42  sing N N 138 
CLR   C5  C6   doub N N 139 
CLR   C5  C10  sing N N 140 
CLR   C6  C7   sing N N 141 
CLR   C6  H6   sing N N 142 
CLR   C7  C8   sing N N 143 
CLR   C7  H71  sing N N 144 
CLR   C7  H72  sing N N 145 
CLR   C8  C9   sing N N 146 
CLR   C8  C14  sing N N 147 
CLR   C8  H8   sing N N 148 
CLR   C9  C10  sing N N 149 
CLR   C9  C11  sing N N 150 
CLR   C9  H9   sing N N 151 
CLR   C10 C19  sing N N 152 
CLR   C11 C12  sing N N 153 
CLR   C11 H111 sing N N 154 
CLR   C11 H112 sing N N 155 
CLR   C12 C13  sing N N 156 
CLR   C12 H121 sing N N 157 
CLR   C12 H122 sing N N 158 
CLR   C13 C14  sing N N 159 
CLR   C13 C17  sing N N 160 
CLR   C13 C18  sing N N 161 
CLR   C14 C15  sing N N 162 
CLR   C14 H14  sing N N 163 
CLR   C15 C16  sing N N 164 
CLR   C15 H151 sing N N 165 
CLR   C15 H152 sing N N 166 
CLR   C16 C17  sing N N 167 
CLR   C16 H161 sing N N 168 
CLR   C16 H162 sing N N 169 
CLR   C17 C20  sing N N 170 
CLR   C17 H17  sing N N 171 
CLR   C18 H181 sing N N 172 
CLR   C18 H182 sing N N 173 
CLR   C18 H183 sing N N 174 
CLR   C19 H191 sing N N 175 
CLR   C19 H192 sing N N 176 
CLR   C19 H193 sing N N 177 
CLR   C20 C21  sing N N 178 
CLR   C20 C22  sing N N 179 
CLR   C20 H20  sing N N 180 
CLR   C21 H211 sing N N 181 
CLR   C21 H212 sing N N 182 
CLR   C21 H213 sing N N 183 
CLR   C22 C23  sing N N 184 
CLR   C22 H221 sing N N 185 
CLR   C22 H222 sing N N 186 
CLR   C23 C24  sing N N 187 
CLR   C23 H231 sing N N 188 
CLR   C23 H232 sing N N 189 
CLR   C24 C25  sing N N 190 
CLR   C24 H241 sing N N 191 
CLR   C24 H242 sing N N 192 
CLR   C25 C26  sing N N 193 
CLR   C25 C27  sing N N 194 
CLR   C25 H25  sing N N 195 
CLR   C26 H261 sing N N 196 
CLR   C26 H262 sing N N 197 
CLR   C26 H263 sing N N 198 
CLR   C27 H271 sing N N 199 
CLR   C27 H272 sing N N 200 
CLR   C27 H273 sing N N 201 
CLR   O1  H1   sing N N 202 
CYS   N   CA   sing N N 203 
CYS   N   H    sing N N 204 
CYS   N   H2   sing N N 205 
CYS   CA  C    sing N N 206 
CYS   CA  CB   sing N N 207 
CYS   CA  HA   sing N N 208 
CYS   C   O    doub N N 209 
CYS   C   OXT  sing N N 210 
CYS   CB  SG   sing N N 211 
CYS   CB  HB2  sing N N 212 
CYS   CB  HB3  sing N N 213 
CYS   SG  HG   sing N N 214 
CYS   OXT HXT  sing N N 215 
GLN   N   CA   sing N N 216 
GLN   N   H    sing N N 217 
GLN   N   H2   sing N N 218 
GLN   CA  C    sing N N 219 
GLN   CA  CB   sing N N 220 
GLN   CA  HA   sing N N 221 
GLN   C   O    doub N N 222 
GLN   C   OXT  sing N N 223 
GLN   CB  CG   sing N N 224 
GLN   CB  HB2  sing N N 225 
GLN   CB  HB3  sing N N 226 
GLN   CG  CD   sing N N 227 
GLN   CG  HG2  sing N N 228 
GLN   CG  HG3  sing N N 229 
GLN   CD  OE1  doub N N 230 
GLN   CD  NE2  sing N N 231 
GLN   NE2 HE21 sing N N 232 
GLN   NE2 HE22 sing N N 233 
GLN   OXT HXT  sing N N 234 
GLU   N   CA   sing N N 235 
GLU   N   H    sing N N 236 
GLU   N   H2   sing N N 237 
GLU   CA  C    sing N N 238 
GLU   CA  CB   sing N N 239 
GLU   CA  HA   sing N N 240 
GLU   C   O    doub N N 241 
GLU   C   OXT  sing N N 242 
GLU   CB  CG   sing N N 243 
GLU   CB  HB2  sing N N 244 
GLU   CB  HB3  sing N N 245 
GLU   CG  CD   sing N N 246 
GLU   CG  HG2  sing N N 247 
GLU   CG  HG3  sing N N 248 
GLU   CD  OE1  doub N N 249 
GLU   CD  OE2  sing N N 250 
GLU   OE2 HE2  sing N N 251 
GLU   OXT HXT  sing N N 252 
GLY   N   CA   sing N N 253 
GLY   N   H    sing N N 254 
GLY   N   H2   sing N N 255 
GLY   CA  C    sing N N 256 
GLY   CA  HA2  sing N N 257 
GLY   CA  HA3  sing N N 258 
GLY   C   O    doub N N 259 
GLY   C   OXT  sing N N 260 
GLY   OXT HXT  sing N N 261 
HIS   N   CA   sing N N 262 
HIS   N   H    sing N N 263 
HIS   N   H2   sing N N 264 
HIS   CA  C    sing N N 265 
HIS   CA  CB   sing N N 266 
HIS   CA  HA   sing N N 267 
HIS   C   O    doub N N 268 
HIS   C   OXT  sing N N 269 
HIS   CB  CG   sing N N 270 
HIS   CB  HB2  sing N N 271 
HIS   CB  HB3  sing N N 272 
HIS   CG  ND1  sing Y N 273 
HIS   CG  CD2  doub Y N 274 
HIS   ND1 CE1  doub Y N 275 
HIS   ND1 HD1  sing N N 276 
HIS   CD2 NE2  sing Y N 277 
HIS   CD2 HD2  sing N N 278 
HIS   CE1 NE2  sing Y N 279 
HIS   CE1 HE1  sing N N 280 
HIS   NE2 HE2  sing N N 281 
HIS   OXT HXT  sing N N 282 
ILE   N   CA   sing N N 283 
ILE   N   H    sing N N 284 
ILE   N   H2   sing N N 285 
ILE   CA  C    sing N N 286 
ILE   CA  CB   sing N N 287 
ILE   CA  HA   sing N N 288 
ILE   C   O    doub N N 289 
ILE   C   OXT  sing N N 290 
ILE   CB  CG1  sing N N 291 
ILE   CB  CG2  sing N N 292 
ILE   CB  HB   sing N N 293 
ILE   CG1 CD1  sing N N 294 
ILE   CG1 HG12 sing N N 295 
ILE   CG1 HG13 sing N N 296 
ILE   CG2 HG21 sing N N 297 
ILE   CG2 HG22 sing N N 298 
ILE   CG2 HG23 sing N N 299 
ILE   CD1 HD11 sing N N 300 
ILE   CD1 HD12 sing N N 301 
ILE   CD1 HD13 sing N N 302 
ILE   OXT HXT  sing N N 303 
LEU   N   CA   sing N N 304 
LEU   N   H    sing N N 305 
LEU   N   H2   sing N N 306 
LEU   CA  C    sing N N 307 
LEU   CA  CB   sing N N 308 
LEU   CA  HA   sing N N 309 
LEU   C   O    doub N N 310 
LEU   C   OXT  sing N N 311 
LEU   CB  CG   sing N N 312 
LEU   CB  HB2  sing N N 313 
LEU   CB  HB3  sing N N 314 
LEU   CG  CD1  sing N N 315 
LEU   CG  CD2  sing N N 316 
LEU   CG  HG   sing N N 317 
LEU   CD1 HD11 sing N N 318 
LEU   CD1 HD12 sing N N 319 
LEU   CD1 HD13 sing N N 320 
LEU   CD2 HD21 sing N N 321 
LEU   CD2 HD22 sing N N 322 
LEU   CD2 HD23 sing N N 323 
LEU   OXT HXT  sing N N 324 
LYS   N   CA   sing N N 325 
LYS   N   H    sing N N 326 
LYS   N   H2   sing N N 327 
LYS   CA  C    sing N N 328 
LYS   CA  CB   sing N N 329 
LYS   CA  HA   sing N N 330 
LYS   C   O    doub N N 331 
LYS   C   OXT  sing N N 332 
LYS   CB  CG   sing N N 333 
LYS   CB  HB2  sing N N 334 
LYS   CB  HB3  sing N N 335 
LYS   CG  CD   sing N N 336 
LYS   CG  HG2  sing N N 337 
LYS   CG  HG3  sing N N 338 
LYS   CD  CE   sing N N 339 
LYS   CD  HD2  sing N N 340 
LYS   CD  HD3  sing N N 341 
LYS   CE  NZ   sing N N 342 
LYS   CE  HE2  sing N N 343 
LYS   CE  HE3  sing N N 344 
LYS   NZ  HZ1  sing N N 345 
LYS   NZ  HZ2  sing N N 346 
LYS   NZ  HZ3  sing N N 347 
LYS   OXT HXT  sing N N 348 
MET   N   CA   sing N N 349 
MET   N   H    sing N N 350 
MET   N   H2   sing N N 351 
MET   CA  C    sing N N 352 
MET   CA  CB   sing N N 353 
MET   CA  HA   sing N N 354 
MET   C   O    doub N N 355 
MET   C   OXT  sing N N 356 
MET   CB  CG   sing N N 357 
MET   CB  HB2  sing N N 358 
MET   CB  HB3  sing N N 359 
MET   CG  SD   sing N N 360 
MET   CG  HG2  sing N N 361 
MET   CG  HG3  sing N N 362 
MET   SD  CE   sing N N 363 
MET   CE  HE1  sing N N 364 
MET   CE  HE2  sing N N 365 
MET   CE  HE3  sing N N 366 
MET   OXT HXT  sing N N 367 
PHE   N   CA   sing N N 368 
PHE   N   H    sing N N 369 
PHE   N   H2   sing N N 370 
PHE   CA  C    sing N N 371 
PHE   CA  CB   sing N N 372 
PHE   CA  HA   sing N N 373 
PHE   C   O    doub N N 374 
PHE   C   OXT  sing N N 375 
PHE   CB  CG   sing N N 376 
PHE   CB  HB2  sing N N 377 
PHE   CB  HB3  sing N N 378 
PHE   CG  CD1  doub Y N 379 
PHE   CG  CD2  sing Y N 380 
PHE   CD1 CE1  sing Y N 381 
PHE   CD1 HD1  sing N N 382 
PHE   CD2 CE2  doub Y N 383 
PHE   CD2 HD2  sing N N 384 
PHE   CE1 CZ   doub Y N 385 
PHE   CE1 HE1  sing N N 386 
PHE   CE2 CZ   sing Y N 387 
PHE   CE2 HE2  sing N N 388 
PHE   CZ  HZ   sing N N 389 
PHE   OXT HXT  sing N N 390 
PRO   N   CA   sing N N 391 
PRO   N   CD   sing N N 392 
PRO   N   H    sing N N 393 
PRO   CA  C    sing N N 394 
PRO   CA  CB   sing N N 395 
PRO   CA  HA   sing N N 396 
PRO   C   O    doub N N 397 
PRO   C   OXT  sing N N 398 
PRO   CB  CG   sing N N 399 
PRO   CB  HB2  sing N N 400 
PRO   CB  HB3  sing N N 401 
PRO   CG  CD   sing N N 402 
PRO   CG  HG2  sing N N 403 
PRO   CG  HG3  sing N N 404 
PRO   CD  HD2  sing N N 405 
PRO   CD  HD3  sing N N 406 
PRO   OXT HXT  sing N N 407 
SER   N   CA   sing N N 408 
SER   N   H    sing N N 409 
SER   N   H2   sing N N 410 
SER   CA  C    sing N N 411 
SER   CA  CB   sing N N 412 
SER   CA  HA   sing N N 413 
SER   C   O    doub N N 414 
SER   C   OXT  sing N N 415 
SER   CB  OG   sing N N 416 
SER   CB  HB2  sing N N 417 
SER   CB  HB3  sing N N 418 
SER   OG  HG   sing N N 419 
SER   OXT HXT  sing N N 420 
THR   N   CA   sing N N 421 
THR   N   H    sing N N 422 
THR   N   H2   sing N N 423 
THR   CA  C    sing N N 424 
THR   CA  CB   sing N N 425 
THR   CA  HA   sing N N 426 
THR   C   O    doub N N 427 
THR   C   OXT  sing N N 428 
THR   CB  OG1  sing N N 429 
THR   CB  CG2  sing N N 430 
THR   CB  HB   sing N N 431 
THR   OG1 HG1  sing N N 432 
THR   CG2 HG21 sing N N 433 
THR   CG2 HG22 sing N N 434 
THR   CG2 HG23 sing N N 435 
THR   OXT HXT  sing N N 436 
TRP   N   CA   sing N N 437 
TRP   N   H    sing N N 438 
TRP   N   H2   sing N N 439 
TRP   CA  C    sing N N 440 
TRP   CA  CB   sing N N 441 
TRP   CA  HA   sing N N 442 
TRP   C   O    doub N N 443 
TRP   C   OXT  sing N N 444 
TRP   CB  CG   sing N N 445 
TRP   CB  HB2  sing N N 446 
TRP   CB  HB3  sing N N 447 
TRP   CG  CD1  doub Y N 448 
TRP   CG  CD2  sing Y N 449 
TRP   CD1 NE1  sing Y N 450 
TRP   CD1 HD1  sing N N 451 
TRP   CD2 CE2  doub Y N 452 
TRP   CD2 CE3  sing Y N 453 
TRP   NE1 CE2  sing Y N 454 
TRP   NE1 HE1  sing N N 455 
TRP   CE2 CZ2  sing Y N 456 
TRP   CE3 CZ3  doub Y N 457 
TRP   CE3 HE3  sing N N 458 
TRP   CZ2 CH2  doub Y N 459 
TRP   CZ2 HZ2  sing N N 460 
TRP   CZ3 CH2  sing Y N 461 
TRP   CZ3 HZ3  sing N N 462 
TRP   CH2 HH2  sing N N 463 
TRP   OXT HXT  sing N N 464 
TYR   N   CA   sing N N 465 
TYR   N   H    sing N N 466 
TYR   N   H2   sing N N 467 
TYR   CA  C    sing N N 468 
TYR   CA  CB   sing N N 469 
TYR   CA  HA   sing N N 470 
TYR   C   O    doub N N 471 
TYR   C   OXT  sing N N 472 
TYR   CB  CG   sing N N 473 
TYR   CB  HB2  sing N N 474 
TYR   CB  HB3  sing N N 475 
TYR   CG  CD1  doub Y N 476 
TYR   CG  CD2  sing Y N 477 
TYR   CD1 CE1  sing Y N 478 
TYR   CD1 HD1  sing N N 479 
TYR   CD2 CE2  doub Y N 480 
TYR   CD2 HD2  sing N N 481 
TYR   CE1 CZ   doub Y N 482 
TYR   CE1 HE1  sing N N 483 
TYR   CE2 CZ   sing Y N 484 
TYR   CE2 HE2  sing N N 485 
TYR   CZ  OH   sing N N 486 
TYR   OH  HH   sing N N 487 
TYR   OXT HXT  sing N N 488 
VAL   N   CA   sing N N 489 
VAL   N   H    sing N N 490 
VAL   N   H2   sing N N 491 
VAL   CA  C    sing N N 492 
VAL   CA  CB   sing N N 493 
VAL   CA  HA   sing N N 494 
VAL   C   O    doub N N 495 
VAL   C   OXT  sing N N 496 
VAL   CB  CG1  sing N N 497 
VAL   CB  CG2  sing N N 498 
VAL   CB  HB   sing N N 499 
VAL   CG1 HG11 sing N N 500 
VAL   CG1 HG12 sing N N 501 
VAL   CG1 HG13 sing N N 502 
VAL   CG2 HG21 sing N N 503 
VAL   CG2 HG22 sing N N 504 
VAL   CG2 HG23 sing N N 505 
VAL   OXT HXT  sing N N 506 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-05-30 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8ZPM 
_em_admin.last_update        2025-04-02 
_em_admin.map_release_date   2025-02-26 
_em_admin.title              'Cryo-EM strucutre of CXCR4 complexed with antagonist AMD070' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         54.4 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
_em_imaging_optics.chr_aberration_corrector   ? 
_em_imaging_optics.energyfilter_lower         ? 
_em_imaging_optics.energyfilter_slit_width    20 
_em_imaging_optics.energyfilter_name          'GIF Bioquantum' 
_em_imaging_optics.energyfilter_upper         ? 
_em_imaging_optics.id                         1 
_em_imaging_optics.imaging_id                 1 
_em_imaging_optics.phase_plate                ? 
_em_imaging_optics.sph_aberration_corrector   ? 
_em_imaging_optics.details                    ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Other government' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           32100963 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8ZPM 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA   A 1 172 ? 117.691 148.969 115.148 1.00 79.14  ? 34  ALA   R N   1 
ATOM   2    C CA  . ALA   A 1 172 ? 117.361 150.335 114.760 1.00 80.60  ? 34  ALA   R CA  1 
ATOM   3    C C   . ALA   A 1 172 ? 118.616 151.197 114.680 1.00 82.01  ? 34  ALA   R C   1 
ATOM   4    O O   . ALA   A 1 172 ? 119.715 150.744 115.007 1.00 83.64  ? 34  ALA   R O   1 
ATOM   5    C CB  . ALA   A 1 172 ? 116.365 150.937 115.737 1.00 79.04  ? 34  ALA   R CB  1 
ATOM   6    N N   . ASN   A 1 173 ? 118.443 152.448 114.242 1.00 78.85  ? 35  ASN   R N   1 
ATOM   7    C CA  . ASN   A 1 173 ? 119.577 153.361 114.145 1.00 77.53  ? 35  ASN   R CA  1 
ATOM   8    C C   . ASN   A 1 173 ? 120.202 153.621 115.508 1.00 75.05  ? 35  ASN   R C   1 
ATOM   9    O O   . ASN   A 1 173 ? 121.420 153.814 115.605 1.00 75.43  ? 35  ASN   R O   1 
ATOM   10   C CB  . ASN   A 1 173 ? 119.143 154.677 113.498 1.00 75.48  ? 35  ASN   R CB  1 
ATOM   11   C CG  . ASN   A 1 173 ? 118.882 154.537 112.009 1.00 78.67  ? 35  ASN   R CG  1 
ATOM   12   O OD1 . ASN   A 1 173 ? 119.371 153.609 111.366 1.00 78.54  ? 35  ASN   R OD1 1 
ATOM   13   N ND2 . ASN   A 1 173 ? 118.107 155.462 111.455 1.00 78.41  ? 35  ASN   R ND2 1 
ATOM   14   N N   . PHE   A 1 174 ? 119.394 153.626 116.570 1.00 68.55  ? 36  PHE   R N   1 
ATOM   15   C CA  . PHE   A 1 174 ? 119.940 153.818 117.908 1.00 68.84  ? 36  PHE   R CA  1 
ATOM   16   C C   . PHE   A 1 174 ? 120.978 152.751 118.226 1.00 71.66  ? 36  PHE   R C   1 
ATOM   17   O O   . PHE   A 1 174 ? 122.088 153.064 118.667 1.00 75.80  ? 36  PHE   R O   1 
ATOM   18   C CB  . PHE   A 1 174 ? 118.819 153.804 118.947 1.00 72.06  ? 36  PHE   R CB  1 
ATOM   19   C CG  . PHE   A 1 174 ? 119.296 153.539 120.348 1.00 75.15  ? 36  PHE   R CG  1 
ATOM   20   C CD1 . PHE   A 1 174 ? 120.217 154.381 120.952 1.00 73.84  ? 36  PHE   R CD1 1 
ATOM   21   C CD2 . PHE   A 1 174 ? 118.829 152.444 121.057 1.00 73.61  ? 36  PHE   R CD2 1 
ATOM   22   C CE1 . PHE   A 1 174 ? 120.662 154.138 122.238 1.00 71.90  ? 36  PHE   R CE1 1 
ATOM   23   C CE2 . PHE   A 1 174 ? 119.269 152.196 122.344 1.00 71.83  ? 36  PHE   R CE2 1 
ATOM   24   C CZ  . PHE   A 1 174 ? 120.187 153.045 122.935 1.00 71.67  ? 36  PHE   R CZ  1 
ATOM   25   N N   . ASN   A 1 175 ? 120.639 151.481 117.992 1.00 63.45  ? 37  ASN   R N   1 
ATOM   26   C CA  . ASN   A 1 175 ? 121.613 150.413 118.192 1.00 65.50  ? 37  ASN   R CA  1 
ATOM   27   C C   . ASN   A 1 175 ? 122.767 150.526 117.203 1.00 64.06  ? 37  ASN   R C   1 
ATOM   28   O O   . ASN   A 1 175 ? 123.926 150.287 117.564 1.00 62.20  ? 37  ASN   R O   1 
ATOM   29   C CB  . ASN   A 1 175 ? 120.934 149.049 118.075 1.00 64.85  ? 37  ASN   R CB  1 
ATOM   30   C CG  . ASN   A 1 175 ? 120.113 148.697 119.302 1.00 66.33  ? 37  ASN   R CG  1 
ATOM   31   O OD1 . ASN   A 1 175 ? 120.529 148.941 120.435 1.00 65.24  ? 37  ASN   R OD1 1 
ATOM   32   N ND2 . ASN   A 1 175 ? 118.941 148.115 119.081 1.00 65.76  ? 37  ASN   R ND2 1 
ATOM   33   N N   . LYS   A 1 176 ? 122.469 150.903 115.955 1.00 60.35  ? 38  LYS   R N   1 
ATOM   34   C CA  . LYS   A 1 176 ? 123.509 151.009 114.935 1.00 57.31  ? 38  LYS   R CA  1 
ATOM   35   C C   . LYS   A 1 176 ? 124.585 152.016 115.324 1.00 58.25  ? 38  LYS   R C   1 
ATOM   36   O O   . LYS   A 1 176 ? 125.754 151.839 114.967 1.00 61.18  ? 38  LYS   R O   1 
ATOM   37   C CB  . LYS   A 1 176 ? 122.879 151.380 113.591 1.00 59.55  ? 38  LYS   R CB  1 
ATOM   38   C CG  . LYS   A 1 176 ? 123.856 151.881 112.536 1.00 61.23  ? 38  LYS   R CG  1 
ATOM   39   C CD  . LYS   A 1 176 ? 123.171 152.045 111.188 1.00 63.12  ? 38  LYS   R CD  1 
ATOM   40   C CE  . LYS   A 1 176 ? 124.181 152.280 110.077 1.00 62.96  ? 38  LYS   R CE  1 
ATOM   41   N NZ  . LYS   A 1 176 ? 124.162 153.690 109.602 1.00 63.14  ? 38  LYS   R NZ  1 
ATOM   42   N N   . ILE   A 1 177 ? 124.219 153.072 116.045 1.00 58.39  ? 39  ILE   R N   1 
ATOM   43   C CA  . ILE   A 1 177 ? 125.230 154.004 116.542 1.00 57.14  ? 39  ILE   R CA  1 
ATOM   44   C C   . ILE   A 1 177 ? 125.771 153.597 117.915 1.00 55.89  ? 39  ILE   R C   1 
ATOM   45   O O   . ILE   A 1 177 ? 126.944 153.848 118.212 1.00 54.41  ? 39  ILE   R O   1 
ATOM   46   C CB  . ILE   A 1 177 ? 124.706 155.455 116.572 1.00 54.61  ? 39  ILE   R CB  1 
ATOM   47   C CG1 . ILE   A 1 177 ? 124.176 155.883 115.202 1.00 61.31  ? 39  ILE   R CG1 1 
ATOM   48   C CG2 . ILE   A 1 177 ? 125.793 156.422 117.021 1.00 52.80  ? 39  ILE   R CG2 1 
ATOM   49   C CD1 . ILE   A 1 177 ? 122.784 156.466 115.232 1.00 60.68  ? 39  ILE   R CD1 1 
ATOM   50   N N   . PHE   A 1 178 ? 124.956 152.963 118.760 1.00 47.38  ? 40  PHE   R N   1 
ATOM   51   C CA  . PHE   A 1 178 ? 125.392 152.669 120.122 1.00 42.06  ? 40  PHE   R CA  1 
ATOM   52   C C   . PHE   A 1 178 ? 126.421 151.546 120.153 1.00 47.73  ? 40  PHE   R C   1 
ATOM   53   O O   . PHE   A 1 178 ? 127.430 151.639 120.861 1.00 52.85  ? 40  PHE   R O   1 
ATOM   54   C CB  . PHE   A 1 178 ? 124.186 152.316 120.992 1.00 41.50  ? 40  PHE   R CB  1 
ATOM   55   C CG  . PHE   A 1 178 ? 124.553 151.820 122.363 1.00 46.73  ? 40  PHE   R CG  1 
ATOM   56   C CD1 . PHE   A 1 178 ? 124.779 152.710 123.396 1.00 50.45  ? 40  PHE   R CD1 1 
ATOM   57   C CD2 . PHE   A 1 178 ? 124.670 150.464 122.619 1.00 49.79  ? 40  PHE   R CD2 1 
ATOM   58   C CE1 . PHE   A 1 178 ? 125.118 152.260 124.657 1.00 49.81  ? 40  PHE   R CE1 1 
ATOM   59   C CE2 . PHE   A 1 178 ? 125.012 150.009 123.876 1.00 46.99  ? 40  PHE   R CE2 1 
ATOM   60   C CZ  . PHE   A 1 178 ? 125.235 150.907 124.896 1.00 46.37  ? 40  PHE   R CZ  1 
ATOM   61   N N   . LEU   A 1 179 ? 126.176 150.467 119.408 1.00 44.36  ? 41  LEU   R N   1 
ATOM   62   C CA  . LEU   A 1 179 ? 127.022 149.279 119.520 1.00 42.84  ? 41  LEU   R CA  1 
ATOM   63   C C   . LEU   A 1 179 ? 128.470 149.515 119.101 1.00 43.15  ? 41  LEU   R C   1 
ATOM   64   O O   . LEU   A 1 179 ? 129.375 149.120 119.857 1.00 41.64  ? 41  LEU   R O   1 
ATOM   65   C CB  . LEU   A 1 179 ? 126.388 148.130 118.728 1.00 41.71  ? 41  LEU   R CB  1 
ATOM   66   C CG  . LEU   A 1 179 ? 125.061 147.616 119.286 1.00 45.78  ? 41  LEU   R CG  1 
ATOM   67   C CD1 . LEU   A 1 179 ? 124.637 146.333 118.592 1.00 42.48  ? 41  LEU   R CD1 1 
ATOM   68   C CD2 . LEU   A 1 179 ? 125.168 147.408 120.786 1.00 41.93  ? 41  LEU   R CD2 1 
ATOM   69   N N   . PRO   A 1 180 ? 128.770 150.115 117.942 1.00 37.10  ? 42  PRO   R N   1 
ATOM   70   C CA  . PRO   A 1 180 ? 130.183 150.316 117.581 1.00 35.05  ? 42  PRO   R CA  1 
ATOM   71   C C   . PRO   A 1 180 ? 130.954 151.179 118.558 1.00 43.27  ? 42  PRO   R C   1 
ATOM   72   O O   . PRO   A 1 180 ? 132.148 150.939 118.758 1.00 46.70  ? 42  PRO   R O   1 
ATOM   73   C CB  . PRO   A 1 180 ? 130.103 150.976 116.198 1.00 30.23  ? 42  PRO   R CB  1 
ATOM   74   C CG  . PRO   A 1 180 ? 128.738 151.527 116.113 1.00 31.98  ? 42  PRO   R CG  1 
ATOM   75   C CD  . PRO   A 1 180 ? 127.882 150.566 116.859 1.00 39.34  ? 42  PRO   R CD  1 
ATOM   76   N N   . THR   A 1 181 ? 130.321 152.179 119.172 1.00 42.17  ? 43  THR   R N   1 
ATOM   77   C CA  . THR   A 1 181 ? 131.038 153.040 120.108 1.00 33.91  ? 43  THR   R CA  1 
ATOM   78   C C   . THR   A 1 181 ? 131.510 152.254 121.324 1.00 38.26  ? 43  THR   R C   1 
ATOM   79   O O   . THR   A 1 181 ? 132.684 152.326 121.713 1.00 48.12  ? 43  THR   R O   1 
ATOM   80   C CB  . THR   A 1 181 ? 130.144 154.203 120.533 1.00 32.76  ? 43  THR   R CB  1 
ATOM   81   O OG1 . THR   A 1 181 ? 129.489 154.747 119.381 1.00 37.41  ? 43  THR   R OG1 1 
ATOM   82   C CG2 . THR   A 1 181 ? 130.969 155.288 121.196 1.00 38.87  ? 43  THR   R CG2 1 
ATOM   83   N N   . ILE   A 1 182 ? 130.605 151.487 121.933 1.00 32.43  ? 44  ILE   R N   1 
ATOM   84   C CA  . ILE   A 1 182 ? 130.972 150.666 123.082 1.00 34.72  ? 44  ILE   R CA  1 
ATOM   85   C C   . ILE   A 1 182 ? 131.991 149.610 122.676 1.00 44.07  ? 44  ILE   R C   1 
ATOM   86   O O   . ILE   A 1 182 ? 132.944 149.333 123.414 1.00 51.33  ? 44  ILE   R O   1 
ATOM   87   C CB  . ILE   A 1 182 ? 129.717 150.036 123.712 1.00 37.90  ? 44  ILE   R CB  1 
ATOM   88   C CG1 . ILE   A 1 182 ? 128.925 151.090 124.485 1.00 37.33  ? 44  ILE   R CG1 1 
ATOM   89   C CG2 . ILE   A 1 182 ? 130.092 148.896 124.634 1.00 38.31  ? 44  ILE   R CG2 1 
ATOM   90   C CD1 . ILE   A 1 182 ? 129.637 151.604 125.714 1.00 40.84  ? 44  ILE   R CD1 1 
ATOM   91   N N   . TYR   A 1 183 ? 131.810 149.004 121.497 1.00 38.70  ? 45  TYR   R N   1 
ATOM   92   C CA  . TYR   A 1 183 ? 132.754 147.984 121.048 1.00 33.22  ? 45  TYR   R CA  1 
ATOM   93   C C   . TYR   A 1 183 ? 134.150 148.562 120.868 1.00 28.64  ? 45  TYR   R C   1 
ATOM   94   O O   . TYR   A 1 183 ? 135.138 147.932 121.250 1.00 26.11  ? 45  TYR   R O   1 
ATOM   95   C CB  . TYR   A 1 183 ? 132.275 147.346 119.745 1.00 37.28  ? 45  TYR   R CB  1 
ATOM   96   C CG  . TYR   A 1 183 ? 131.106 146.405 119.906 1.00 37.56  ? 45  TYR   R CG  1 
ATOM   97   C CD1 . TYR   A 1 183 ? 130.735 145.935 121.154 1.00 35.54  ? 45  TYR   R CD1 1 
ATOM   98   C CD2 . TYR   A 1 183 ? 130.378 145.984 118.806 1.00 37.70  ? 45  TYR   R CD2 1 
ATOM   99   C CE1 . TYR   A 1 183 ? 129.668 145.079 121.302 1.00 39.53  ? 45  TYR   R CE1 1 
ATOM   100  C CE2 . TYR   A 1 183 ? 129.312 145.129 118.944 1.00 31.59  ? 45  TYR   R CE2 1 
ATOM   101  C CZ  . TYR   A 1 183 ? 128.961 144.679 120.193 1.00 39.64  ? 45  TYR   R CZ  1 
ATOM   102  O OH  . TYR   A 1 183 ? 127.894 143.823 120.333 1.00 51.18  ? 45  TYR   R OH  1 
ATOM   103  N N   . SER   A 1 184 ? 134.254 149.759 120.289 1.00 30.06  ? 46  SER   R N   1 
ATOM   104  C CA  . SER   A 1 184 ? 135.557 150.384 120.095 1.00 32.77  ? 46  SER   R CA  1 
ATOM   105  C C   . SER   A 1 184 ? 136.190 150.780 121.421 1.00 37.82  ? 46  SER   R C   1 
ATOM   106  O O   . SER   A 1 184 ? 137.401 150.612 121.610 1.00 44.41  ? 46  SER   R O   1 
ATOM   107  C CB  . SER   A 1 184 ? 135.422 151.598 119.181 1.00 27.83  ? 46  SER   R CB  1 
ATOM   108  O OG  . SER   A 1 184 ? 134.838 151.231 117.945 1.00 32.90  ? 46  SER   R OG  1 
ATOM   109  N N   . ILE   A 1 185 ? 135.394 151.311 122.352 1.00 33.91  ? 47  ILE   R N   1 
ATOM   110  C CA  . ILE   A 1 185 ? 135.933 151.657 123.666 1.00 32.03  ? 47  ILE   R CA  1 
ATOM   111  C C   . ILE   A 1 185 ? 136.476 150.412 124.359 1.00 38.78  ? 47  ILE   R C   1 
ATOM   112  O O   . ILE   A 1 185 ? 137.593 150.411 124.897 1.00 41.73  ? 47  ILE   R O   1 
ATOM   113  C CB  . ILE   A 1 185 ? 134.858 152.354 124.520 1.00 34.76  ? 47  ILE   R CB  1 
ATOM   114  C CG1 . ILE   A 1 185 ? 134.698 153.811 124.092 1.00 39.54  ? 47  ILE   R CG1 1 
ATOM   115  C CG2 . ILE   A 1 185 ? 135.206 152.270 125.993 1.00 33.77  ? 47  ILE   R CG2 1 
ATOM   116  C CD1 . ILE   A 1 185 ? 133.607 154.543 124.837 1.00 39.02  ? 47  ILE   R CD1 1 
ATOM   117  N N   . ILE   A 1 186 ? 135.695 149.328 124.344 1.00 37.68  ? 48  ILE   R N   1 
ATOM   118  C CA  . ILE   A 1 186 ? 136.121 148.091 124.989 1.00 34.49  ? 48  ILE   R CA  1 
ATOM   119  C C   . ILE   A 1 186 ? 137.352 147.525 124.295 1.00 38.43  ? 48  ILE   R C   1 
ATOM   120  O O   . ILE   A 1 186 ? 138.276 147.043 124.951 1.00 36.82  ? 48  ILE   R O   1 
ATOM   121  C CB  . ILE   A 1 186 ? 134.970 147.070 125.016 1.00 33.76  ? 48  ILE   R CB  1 
ATOM   122  C CG1 . ILE   A 1 186 ? 133.854 147.544 125.944 1.00 34.16  ? 48  ILE   R CG1 1 
ATOM   123  C CG2 . ILE   A 1 186 ? 135.476 145.715 125.472 1.00 26.69  ? 48  ILE   R CG2 1 
ATOM   124  C CD1 . ILE   A 1 186 ? 132.657 146.625 125.965 1.00 38.42  ? 48  ILE   R CD1 1 
ATOM   125  N N   . PHE   A 1 187 ? 137.384 147.570 122.963 1.00 35.59  ? 49  PHE   R N   1 
ATOM   126  C CA  . PHE   A 1 187 ? 138.535 147.058 122.230 1.00 26.40  ? 49  PHE   R CA  1 
ATOM   127  C C   . PHE   A 1 187 ? 139.798 147.821 122.592 1.00 29.68  ? 49  PHE   R C   1 
ATOM   128  O O   . PHE   A 1 187 ? 140.838 147.219 122.870 1.00 40.78  ? 49  PHE   R O   1 
ATOM   129  C CB  . PHE   A 1 187 ? 138.273 147.136 120.727 1.00 32.79  ? 49  PHE   R CB  1 
ATOM   130  C CG  . PHE   A 1 187 ? 139.512 147.049 119.886 1.00 34.04  ? 49  PHE   R CG  1 
ATOM   131  C CD1 . PHE   A 1 187 ? 140.149 145.839 119.692 1.00 33.15  ? 49  PHE   R CD1 1 
ATOM   132  C CD2 . PHE   A 1 187 ? 140.029 148.176 119.274 1.00 33.60  ? 49  PHE   R CD2 1 
ATOM   133  C CE1 . PHE   A 1 187 ? 141.282 145.755 118.911 1.00 34.14  ? 49  PHE   R CE1 1 
ATOM   134  C CE2 . PHE   A 1 187 ? 141.164 148.097 118.493 1.00 35.90  ? 49  PHE   R CE2 1 
ATOM   135  C CZ  . PHE   A 1 187 ? 141.791 146.885 118.313 1.00 32.93  ? 49  PHE   R CZ  1 
ATOM   136  N N   . LEU   A 1 188 ? 139.721 149.153 122.618 1.00 36.26  ? 50  LEU   R N   1 
ATOM   137  C CA  . LEU   A 1 188 ? 140.891 149.951 122.966 1.00 40.98  ? 50  LEU   R CA  1 
ATOM   138  C C   . LEU   A 1 188 ? 141.365 149.646 124.382 1.00 40.06  ? 50  LEU   R C   1 
ATOM   139  O O   . LEU   A 1 188 ? 142.547 149.341 124.604 1.00 41.71  ? 50  LEU   R O   1 
ATOM   140  C CB  . LEU   A 1 188 ? 140.571 151.438 122.814 1.00 35.65  ? 50  LEU   R CB  1 
ATOM   141  C CG  . LEU   A 1 188 ? 141.083 152.127 121.550 1.00 40.30  ? 50  LEU   R CG  1 
ATOM   142  C CD1 . LEU   A 1 188 ? 140.233 151.756 120.349 1.00 39.46  ? 50  LEU   R CD1 1 
ATOM   143  C CD2 . LEU   A 1 188 ? 141.109 153.632 121.744 1.00 43.67  ? 50  LEU   R CD2 1 
ATOM   144  N N   . THR   A 1 189 ? 140.451 149.712 125.357 1.00 30.61  ? 51  THR   R N   1 
ATOM   145  C CA  . THR   A 1 189 ? 140.849 149.497 126.745 1.00 33.99  ? 51  THR   R CA  1 
ATOM   146  C C   . THR   A 1 189 ? 141.367 148.081 126.963 1.00 40.92  ? 51  THR   R C   1 
ATOM   147  O O   . THR   A 1 189 ? 142.375 147.883 127.649 1.00 44.79  ? 51  THR   R O   1 
ATOM   148  C CB  . THR   A 1 189 ? 139.684 149.792 127.687 1.00 36.26  ? 51  THR   R CB  1 
ATOM   149  O OG1 . THR   A 1 189 ? 138.514 149.100 127.236 1.00 44.64  ? 51  THR   R OG1 1 
ATOM   150  C CG2 . THR   A 1 189 ? 139.401 151.282 127.728 1.00 41.25  ? 51  THR   R CG2 1 
ATOM   151  N N   . GLY   A 1 190 ? 140.694 147.083 126.387 1.00 39.72  ? 52  GLY   R N   1 
ATOM   152  C CA  . GLY   A 1 190 ? 141.135 145.710 126.550 1.00 39.19  ? 52  GLY   R CA  1 
ATOM   153  C C   . GLY   A 1 190 ? 142.478 145.443 125.905 1.00 36.12  ? 52  GLY   R C   1 
ATOM   154  O O   . GLY   A 1 190 ? 143.339 144.801 126.507 1.00 38.08  ? 52  GLY   R O   1 
ATOM   155  N N   . ILE   A 1 191 ? 142.687 145.940 124.684 1.00 31.55  ? 53  ILE   R N   1 
ATOM   156  C CA  . ILE   A 1 191 ? 143.982 145.776 124.035 1.00 24.47  ? 53  ILE   R CA  1 
ATOM   157  C C   . ILE   A 1 191 ? 145.077 146.373 124.900 1.00 33.10  ? 53  ILE   R C   1 
ATOM   158  O O   . ILE   A 1 191 ? 146.066 145.705 125.221 1.00 46.96  ? 53  ILE   R O   1 
ATOM   159  C CB  . ILE   A 1 191 ? 143.969 146.408 122.632 1.00 31.83  ? 53  ILE   R CB  1 
ATOM   160  C CG1 . ILE   A 1 191 ? 143.373 145.443 121.612 1.00 40.30  ? 53  ILE   R CG1 1 
ATOM   161  C CG2 . ILE   A 1 191 ? 145.374 146.801 122.209 1.00 31.40  ? 53  ILE   R CG2 1 
ATOM   162  C CD1 . ILE   A 1 191 ? 144.298 144.319 121.223 1.00 38.42  ? 53  ILE   R CD1 1 
ATOM   163  N N   . VAL   A 1 192 ? 144.894 147.622 125.337 1.00 33.20  ? 54  VAL   R N   1 
ATOM   164  C CA  . VAL   A 1 192 ? 145.951 148.292 126.092 1.00 38.89  ? 54  VAL   R CA  1 
ATOM   165  C C   . VAL   A 1 192 ? 146.215 147.560 127.404 1.00 42.19  ? 54  VAL   R C   1 
ATOM   166  O O   . VAL   A 1 192 ? 147.361 147.214 127.723 1.00 43.60  ? 54  VAL   R O   1 
ATOM   167  C CB  . VAL   A 1 192 ? 145.592 149.771 126.323 1.00 39.09  ? 54  VAL   R CB  1 
ATOM   168  C CG1 . VAL   A 1 192 ? 146.232 150.289 127.602 1.00 37.65  ? 54  VAL   R CG1 1 
ATOM   169  C CG2 . VAL   A 1 192 ? 146.028 150.607 125.132 1.00 41.49  ? 54  VAL   R CG2 1 
ATOM   170  N N   . GLY   A 1 193 ? 145.157 147.279 128.168 1.00 34.67  ? 55  GLY   R N   1 
ATOM   171  C CA  . GLY   A 1 193 ? 145.345 146.667 129.472 1.00 31.39  ? 55  GLY   R CA  1 
ATOM   172  C C   . GLY   A 1 193 ? 145.910 145.261 129.398 1.00 40.13  ? 55  GLY   R C   1 
ATOM   173  O O   . GLY   A 1 193 ? 146.852 144.922 130.119 1.00 44.78  ? 55  GLY   R O   1 
ATOM   174  N N   . ASN   A 1 194 ? 145.339 144.418 128.532 1.00 40.39  ? 56  ASN   R N   1 
ATOM   175  C CA  . ASN   A 1 194 ? 145.797 143.039 128.430 1.00 34.38  ? 56  ASN   R CA  1 
ATOM   176  C C   . ASN   A 1 194 ? 147.207 142.962 127.863 1.00 34.78  ? 56  ASN   R C   1 
ATOM   177  O O   . ASN   A 1 194 ? 148.021 142.161 128.336 1.00 42.35  ? 56  ASN   R O   1 
ATOM   178  C CB  . ASN   A 1 194 ? 144.821 142.228 127.583 1.00 27.98  ? 56  ASN   R CB  1 
ATOM   179  C CG  . ASN   A 1 194 ? 143.462 142.102 128.234 1.00 29.92  ? 56  ASN   R CG  1 
ATOM   180  O OD1 . ASN   A 1 194 ? 143.355 141.995 129.453 1.00 31.15  ? 56  ASN   R OD1 1 
ATOM   181  N ND2 . ASN   A 1 194 ? 142.414 142.114 127.425 1.00 32.72  ? 56  ASN   R ND2 1 
ATOM   182  N N   . GLY   A 1 195 ? 147.526 143.781 126.858 1.00 30.59  ? 57  GLY   R N   1 
ATOM   183  C CA  . GLY   A 1 195 ? 148.891 143.818 126.372 1.00 33.84  ? 57  GLY   R CA  1 
ATOM   184  C C   . GLY   A 1 195 ? 149.870 144.252 127.443 1.00 37.14  ? 57  GLY   R C   1 
ATOM   185  O O   . GLY   A 1 195 ? 150.949 143.673 127.577 1.00 37.03  ? 57  GLY   R O   1 
ATOM   186  N N   . LEU   A 1 196 ? 149.500 145.265 128.233 1.00 42.86  ? 58  LEU   R N   1 
ATOM   187  C CA  . LEU   A 1 196 ? 150.380 145.714 129.307 1.00 47.80  ? 58  LEU   R CA  1 
ATOM   188  C C   . LEU   A 1 196 ? 150.581 144.625 130.354 1.00 50.27  ? 58  LEU   R C   1 
ATOM   189  O O   . LEU   A 1 196 ? 151.705 144.403 130.816 1.00 54.02  ? 58  LEU   R O   1 
ATOM   190  C CB  . LEU   A 1 196 ? 149.817 146.981 129.949 1.00 42.22  ? 58  LEU   R CB  1 
ATOM   191  C CG  . LEU   A 1 196 ? 150.213 148.295 129.278 1.00 45.19  ? 58  LEU   R CG  1 
ATOM   192  C CD1 . LEU   A 1 196 ? 149.638 149.478 130.039 1.00 48.06  ? 58  LEU   R CD1 1 
ATOM   193  C CD2 . LEU   A 1 196 ? 151.725 148.402 129.179 1.00 46.28  ? 58  LEU   R CD2 1 
ATOM   194  N N   . VAL   A 1 197 ? 149.507 143.930 130.734 1.00 46.26  ? 59  VAL   R N   1 
ATOM   195  C CA  . VAL   A 1 197 ? 149.617 142.878 131.743 1.00 41.94  ? 59  VAL   R CA  1 
ATOM   196  C C   . VAL   A 1 197 ? 150.491 141.740 131.232 1.00 46.90  ? 59  VAL   R C   1 
ATOM   197  O O   . VAL   A 1 197 ? 151.364 141.231 131.947 1.00 46.75  ? 59  VAL   R O   1 
ATOM   198  C CB  . VAL   A 1 197 ? 148.221 142.373 132.150 1.00 39.64  ? 59  VAL   R CB  1 
ATOM   199  C CG1 . VAL   A 1 197 ? 148.333 141.049 132.876 1.00 37.30  ? 59  VAL   R CG1 1 
ATOM   200  C CG2 . VAL   A 1 197 ? 147.522 143.397 133.020 1.00 46.72  ? 59  VAL   R CG2 1 
ATOM   201  N N   . ILE   A 1 198 ? 150.268 141.324 129.983 1.00 46.02  ? 60  ILE   R N   1 
ATOM   202  C CA  . ILE   A 1 198 ? 151.047 140.228 129.417 1.00 37.75  ? 60  ILE   R CA  1 
ATOM   203  C C   . ILE   A 1 198 ? 152.514 140.618 129.304 1.00 42.07  ? 60  ILE   R C   1 
ATOM   204  O O   . ILE   A 1 198 ? 153.404 139.822 129.618 1.00 50.94  ? 60  ILE   R O   1 
ATOM   205  C CB  . ILE   A 1 198 ? 150.460 139.800 128.059 1.00 38.92  ? 60  ILE   R CB  1 
ATOM   206  C CG1 . ILE   A 1 198 ? 149.100 139.129 128.260 1.00 42.07  ? 60  ILE   R CG1 1 
ATOM   207  C CG2 . ILE   A 1 198 ? 151.406 138.858 127.342 1.00 39.24  ? 60  ILE   R CG2 1 
ATOM   208  C CD1 . ILE   A 1 198 ? 148.456 138.650 126.983 1.00 36.16  ? 60  ILE   R CD1 1 
ATOM   209  N N   . LEU   A 1 199 ? 152.794 141.847 128.865 1.00 47.02  ? 61  LEU   R N   1 
ATOM   210  C CA  . LEU   A 1 199 ? 154.181 142.287 128.754 1.00 48.13  ? 61  LEU   R CA  1 
ATOM   211  C C   . LEU   A 1 199 ? 154.840 142.362 130.126 1.00 51.96  ? 61  LEU   R C   1 
ATOM   212  O O   . LEU   A 1 199 ? 156.015 142.009 130.277 1.00 56.99  ? 61  LEU   R O   1 
ATOM   213  C CB  . LEU   A 1 199 ? 154.238 143.636 128.026 1.00 48.11  ? 61  LEU   R CB  1 
ATOM   214  C CG  . LEU   A 1 199 ? 155.527 144.413 127.708 1.00 54.67  ? 61  LEU   R CG  1 
ATOM   215  C CD1 . LEU   A 1 199 ? 155.179 145.594 126.817 1.00 53.52  ? 61  LEU   R CD1 1 
ATOM   216  C CD2 . LEU   A 1 199 ? 156.281 144.924 128.932 1.00 54.76  ? 61  LEU   R CD2 1 
ATOM   217  N N   . VAL   A 1 200 ? 154.103 142.824 131.138 1.00 55.61  ? 62  VAL   R N   1 
ATOM   218  C CA  . VAL   A 1 200 ? 154.671 142.944 132.476 1.00 57.28  ? 62  VAL   R CA  1 
ATOM   219  C C   . VAL   A 1 200 ? 154.976 141.571 133.062 1.00 66.19  ? 62  VAL   R C   1 
ATOM   220  O O   . VAL   A 1 200 ? 156.034 141.363 133.667 1.00 71.29  ? 62  VAL   R O   1 
ATOM   221  C CB  . VAL   A 1 200 ? 153.724 143.756 133.379 1.00 54.56  ? 62  VAL   R CB  1 
ATOM   222  C CG1 . VAL   A 1 200 ? 154.018 143.492 134.842 1.00 56.53  ? 62  VAL   R CG1 1 
ATOM   223  C CG2 . VAL   A 1 200 ? 153.854 145.236 133.074 1.00 57.97  ? 62  VAL   R CG2 1 
ATOM   224  N N   . MET   A 1 201 ? 154.069 140.609 132.891 1.00 66.20  ? 63  MET   R N   1 
ATOM   225  C CA  . MET   A 1 201 ? 154.251 139.301 133.507 1.00 61.30  ? 63  MET   R CA  1 
ATOM   226  C C   . MET   A 1 201 ? 154.897 138.270 132.591 1.00 63.83  ? 63  MET   R C   1 
ATOM   227  O O   . MET   A 1 201 ? 155.003 137.104 132.984 1.00 69.79  ? 63  MET   R O   1 
ATOM   228  C CB  . MET   A 1 201 ? 152.913 138.764 134.015 1.00 58.49  ? 63  MET   R CB  1 
ATOM   229  C CG  . MET   A 1 201 ? 152.482 139.407 135.314 1.00 65.08  ? 63  MET   R CG  1 
ATOM   230  S SD  . MET   A 1 201 ? 150.719 139.295 135.641 1.00 73.22  ? 63  MET   R SD  1 
ATOM   231  C CE  . MET   A 1 201 ? 150.642 140.218 137.170 1.00 60.36  ? 63  MET   R CE  1 
ATOM   232  N N   . GLY   A 1 202 ? 155.333 138.657 131.396 1.00 70.68  ? 64  GLY   R N   1 
ATOM   233  C CA  . GLY   A 1 202 ? 156.022 137.728 130.527 1.00 70.53  ? 64  GLY   R CA  1 
ATOM   234  C C   . GLY   A 1 202 ? 157.526 137.893 130.550 1.00 75.49  ? 64  GLY   R C   1 
ATOM   235  O O   . GLY   A 1 202 ? 158.194 137.392 131.459 1.00 79.99  ? 64  GLY   R O   1 
ATOM   236  N N   . TYR   A 1 203 ? 158.070 138.589 129.548 1.00 87.40  ? 65  TYR   R N   1 
ATOM   237  C CA  . TYR   A 1 203 ? 159.519 138.732 129.443 1.00 89.03  ? 65  TYR   R CA  1 
ATOM   238  C C   . TYR   A 1 203 ? 160.119 139.415 130.665 1.00 90.95  ? 65  TYR   R C   1 
ATOM   239  O O   . TYR   A 1 203 ? 161.273 139.147 131.018 1.00 92.26  ? 65  TYR   R O   1 
ATOM   240  C CB  . TYR   A 1 203 ? 159.884 139.504 128.173 1.00 87.15  ? 65  TYR   R CB  1 
ATOM   241  C CG  . TYR   A 1 203 ? 159.863 138.669 126.912 1.00 88.82  ? 65  TYR   R CG  1 
ATOM   242  C CD1 . TYR   A 1 203 ? 159.275 137.412 126.894 1.00 89.94  ? 65  TYR   R CD1 1 
ATOM   243  C CD2 . TYR   A 1 203 ? 160.443 139.136 125.740 1.00 90.05  ? 65  TYR   R CD2 1 
ATOM   244  C CE1 . TYR   A 1 203 ? 159.258 136.646 125.744 1.00 90.67  ? 65  TYR   R CE1 1 
ATOM   245  C CE2 . TYR   A 1 203 ? 160.432 138.377 124.584 1.00 91.82  ? 65  TYR   R CE2 1 
ATOM   246  C CZ  . TYR   A 1 203 ? 159.838 137.133 124.592 1.00 92.30  ? 65  TYR   R CZ  1 
ATOM   247  O OH  . TYR   A 1 203 ? 159.823 136.373 123.445 1.00 91.09  ? 65  TYR   R OH  1 
ATOM   248  N N   . GLN   A 1 204 ? 159.360 140.292 131.326 1.00 83.36  ? 66  GLN   R N   1 
ATOM   249  C CA  . GLN   A 1 204 ? 159.882 140.965 132.509 1.00 81.91  ? 66  GLN   R CA  1 
ATOM   250  C C   . GLN   A 1 204 ? 160.057 140.011 133.684 1.00 85.41  ? 66  GLN   R C   1 
ATOM   251  O O   . GLN   A 1 204 ? 160.919 140.253 134.536 1.00 86.26  ? 66  GLN   R O   1 
ATOM   252  C CB  . GLN   A 1 204 ? 158.966 142.120 132.907 1.00 79.72  ? 66  GLN   R CB  1 
ATOM   253  C CG  . GLN   A 1 204 ? 158.834 143.197 131.847 1.00 83.10  ? 66  GLN   R CG  1 
ATOM   254  C CD  . GLN   A 1 204 ? 160.161 143.833 131.496 1.00 84.93  ? 66  GLN   R CD  1 
ATOM   255  O OE1 . GLN   A 1 204 ? 160.999 144.068 132.366 1.00 86.26  ? 66  GLN   R OE1 1 
ATOM   256  N NE2 . GLN   A 1 204 ? 160.362 144.113 130.215 1.00 82.61  ? 66  GLN   R NE2 1 
ATOM   257  N N   . LYS   A 1 205 ? 159.265 138.937 133.741 1.00 86.90  ? 67  LYS   R N   1 
ATOM   258  C CA  . LYS   A 1 205 ? 159.373 137.917 134.786 1.00 84.73  ? 67  LYS   R CA  1 
ATOM   259  C C   . LYS   A 1 205 ? 159.234 138.522 136.181 1.00 86.38  ? 67  LYS   R C   1 
ATOM   260  O O   . LYS   A 1 205 ? 160.056 138.284 137.067 1.00 87.38  ? 67  LYS   R O   1 
ATOM   261  C CB  . LYS   A 1 205 ? 160.681 137.132 134.661 1.00 84.90  ? 67  LYS   R CB  1 
ATOM   262  C CG  . LYS   A 1 205 ? 160.787 136.309 133.389 1.00 84.78  ? 67  LYS   R CG  1 
ATOM   263  C CD  . LYS   A 1 205 ? 162.102 135.550 133.335 1.00 86.44  ? 67  LYS   R CD  1 
ATOM   264  C CE  . LYS   A 1 205 ? 163.272 136.493 133.110 1.00 86.32  ? 67  LYS   R CE  1 
ATOM   265  N NZ  . LYS   A 1 205 ? 163.206 137.147 131.775 1.00 84.54  ? 67  LYS   R NZ  1 
ATOM   266  N N   . LYS   A 1 206 ? 158.182 139.312 136.377 1.00 86.37  ? 68  LYS   R N   1 
ATOM   267  C CA  . LYS   A 1 206 ? 157.885 139.888 137.681 1.00 88.03  ? 68  LYS   R CA  1 
ATOM   268  C C   . LYS   A 1 206 ? 157.200 138.827 138.543 1.00 88.73  ? 68  LYS   R C   1 
ATOM   269  O O   . LYS   A 1 206 ? 157.237 137.633 138.235 1.00 87.77  ? 68  LYS   R O   1 
ATOM   270  C CB  . LYS   A 1 206 ? 157.060 141.162 137.522 1.00 85.62  ? 68  LYS   R CB  1 
ATOM   271  C CG  . LYS   A 1 206 ? 157.875 142.340 137.001 1.00 86.51  ? 68  LYS   R CG  1 
ATOM   272  C CD  . LYS   A 1 206 ? 157.037 143.598 136.850 1.00 86.91  ? 68  LYS   R CD  1 
ATOM   273  C CE  . LYS   A 1 206 ? 156.698 144.209 138.199 1.00 88.40  ? 68  LYS   R CE  1 
ATOM   274  N NZ  . LYS   A 1 206 ? 156.002 145.518 138.056 1.00 87.76  ? 68  LYS   R NZ  1 
ATOM   275  N N   . LEU   A 1 207 ? 156.594 139.249 139.654 1.00 88.57  ? 69  LEU   R N   1 
ATOM   276  C CA  . LEU   A 1 207 ? 156.040 138.311 140.625 1.00 87.49  ? 69  LEU   R CA  1 
ATOM   277  C C   . LEU   A 1 207 ? 155.093 137.324 139.952 1.00 88.09  ? 69  LEU   R C   1 
ATOM   278  O O   . LEU   A 1 207 ? 154.191 137.717 139.207 1.00 88.34  ? 69  LEU   R O   1 
ATOM   279  C CB  . LEU   A 1 207 ? 155.311 139.077 141.731 1.00 85.99  ? 69  LEU   R CB  1 
ATOM   280  C CG  . LEU   A 1 207 ? 154.805 138.253 142.916 1.00 86.63  ? 69  LEU   R CG  1 
ATOM   281  C CD1 . LEU   A 1 207 ? 155.972 137.714 143.729 1.00 86.17  ? 69  LEU   R CD1 1 
ATOM   282  C CD2 . LEU   A 1 207 ? 153.881 139.083 143.791 1.00 87.54  ? 69  LEU   R CD2 1 
ATOM   283  N N   . ARG   A 1 208 ? 155.312 136.036 140.212 1.00 80.53  ? 70  ARG   R N   1 
ATOM   284  C CA  . ARG   A 1 208 ? 154.624 134.954 139.513 1.00 81.42  ? 70  ARG   R CA  1 
ATOM   285  C C   . ARG   A 1 208 ? 154.126 133.900 140.496 1.00 84.86  ? 70  ARG   R C   1 
ATOM   286  O O   . ARG   A 1 208 ? 154.385 132.704 140.344 1.00 84.70  ? 70  ARG   R O   1 
ATOM   287  C CB  . ARG   A 1 208 ? 155.526 134.318 138.456 1.00 76.83  ? 70  ARG   R CB  1 
ATOM   288  C CG  . ARG   A 1 208 ? 155.657 135.135 137.179 1.00 79.62  ? 70  ARG   R CG  1 
ATOM   289  C CD  . ARG   A 1 208 ? 154.380 135.131 136.360 1.00 78.65  ? 70  ARG   R CD  1 
ATOM   290  N NE  . ARG   A 1 208 ? 154.068 133.814 135.821 1.00 80.10  ? 70  ARG   R NE  1 
ATOM   291  C CZ  . ARG   A 1 208 ? 154.557 133.341 134.683 1.00 79.83  ? 70  ARG   R CZ  1 
ATOM   292  N NH1 . ARG   A 1 208 ? 155.396 134.048 133.945 1.00 77.52  ? 70  ARG   R NH1 1 
ATOM   293  N NH2 . ARG   A 1 208 ? 154.194 132.129 134.274 1.00 79.50  ? 70  ARG   R NH2 1 
ATOM   294  N N   . SER   A 1 209 ? 153.409 134.328 141.533 1.00 70.76  ? 71  SER   R N   1 
ATOM   295  C CA  . SER   A 1 209 ? 152.720 133.373 142.387 1.00 63.82  ? 71  SER   R CA  1 
ATOM   296  C C   . SER   A 1 209 ? 151.600 132.689 141.598 1.00 67.15  ? 71  SER   R C   1 
ATOM   297  O O   . SER   A 1 209 ? 151.351 132.989 140.426 1.00 75.96  ? 71  SER   R O   1 
ATOM   298  C CB  . SER   A 1 209 ? 152.184 134.066 143.636 1.00 63.44  ? 71  SER   R CB  1 
ATOM   299  O OG  . SER   A 1 209 ? 150.872 134.553 143.430 1.00 65.85  ? 71  SER   R OG  1 
ATOM   300  N N   . MET   A 1 210 ? 150.915 131.747 142.247 1.00 57.50  ? 72  MET   R N   1 
ATOM   301  C CA  . MET   A 1 210 ? 149.895 130.961 141.556 1.00 58.53  ? 72  MET   R CA  1 
ATOM   302  C C   . MET   A 1 210 ? 148.784 131.849 141.012 1.00 57.91  ? 72  MET   R C   1 
ATOM   303  O O   . MET   A 1 210 ? 148.310 131.656 139.883 1.00 67.55  ? 72  MET   R O   1 
ATOM   304  C CB  . MET   A 1 210 ? 149.327 129.903 142.500 1.00 63.32  ? 72  MET   R CB  1 
ATOM   305  C CG  . MET   A 1 210 ? 150.313 128.880 143.093 1.00 65.50  ? 72  MET   R CG  1 
ATOM   306  S SD  . MET   A 1 210 ? 151.559 128.071 142.041 1.00 77.36  ? 72  MET   R SD  1 
ATOM   307  C CE  . MET   A 1 210 ? 152.864 129.284 141.818 1.00 61.24  ? 72  MET   R CE  1 
ATOM   308  N N   . THR   A 1 211 ? 148.355 132.832 141.802 1.00 49.29  ? 73  THR   R N   1 
ATOM   309  C CA  . THR   A 1 211 ? 147.334 133.760 141.334 1.00 51.02  ? 73  THR   R CA  1 
ATOM   310  C C   . THR   A 1 211 ? 147.835 134.576 140.149 1.00 53.00  ? 73  THR   R C   1 
ATOM   311  O O   . THR   A 1 211 ? 147.068 134.885 139.230 1.00 50.67  ? 73  THR   R O   1 
ATOM   312  C CB  . THR   A 1 211 ? 146.897 134.671 142.477 1.00 50.51  ? 73  THR   R CB  1 
ATOM   313  O OG1 . THR   A 1 211 ? 148.003 135.485 142.888 1.00 57.36  ? 73  THR   R OG1 1 
ATOM   314  C CG2 . THR   A 1 211 ? 146.415 133.838 143.652 1.00 49.77  ? 73  THR   R CG2 1 
ATOM   315  N N   . ASP   A 1 212 ? 149.123 134.924 140.146 1.00 55.79  ? 74  ASP   R N   1 
ATOM   316  C CA  . ASP   A 1 212 ? 149.695 135.629 139.003 1.00 53.87  ? 74  ASP   R CA  1 
ATOM   317  C C   . ASP   A 1 212 ? 149.699 134.759 137.750 1.00 56.30  ? 74  ASP   R C   1 
ATOM   318  O O   . ASP   A 1 212 ? 149.417 135.251 136.654 1.00 64.11  ? 74  ASP   R O   1 
ATOM   319  C CB  . ASP   A 1 212 ? 151.106 136.108 139.333 1.00 57.24  ? 74  ASP   R CB  1 
ATOM   320  C CG  . ASP   A 1 212 ? 151.127 137.122 140.460 1.00 60.95  ? 74  ASP   R CG  1 
ATOM   321  O OD1 . ASP   A 1 212 ? 150.140 137.873 140.605 1.00 58.48  ? 74  ASP   R OD1 1 
ATOM   322  O OD2 . ASP   A 1 212 ? 152.131 137.169 141.201 1.00 63.04  ? 74  ASP   R OD2 1 
ATOM   323  N N   . LYS   A 1 213 ? 150.020 133.470 137.885 1.00 44.01  ? 75  LYS   R N   1 
ATOM   324  C CA  . LYS   A 1 213 ? 149.960 132.569 136.735 1.00 45.57  ? 75  LYS   R CA  1 
ATOM   325  C C   . LYS   A 1 213 ? 148.541 132.472 136.188 1.00 43.49  ? 75  LYS   R C   1 
ATOM   326  O O   . LYS   A 1 213 ? 148.317 132.535 134.970 1.00 51.95  ? 75  LYS   R O   1 
ATOM   327  C CB  . LYS   A 1 213 ? 150.467 131.181 137.126 1.00 46.21  ? 75  LYS   R CB  1 
ATOM   328  C CG  . LYS   A 1 213 ? 151.962 130.989 137.012 1.00 50.66  ? 75  LYS   R CG  1 
ATOM   329  C CD  . LYS   A 1 213 ? 152.323 129.523 137.179 1.00 52.46  ? 75  LYS   R CD  1 
ATOM   330  C CE  . LYS   A 1 213 ? 153.826 129.316 137.162 1.00 53.73  ? 75  LYS   R CE  1 
ATOM   331  N NZ  . LYS   A 1 213 ? 154.486 129.940 138.340 1.00 55.14  ? 75  LYS   R NZ  1 
ATOM   332  N N   . TYR   A 1 214 ? 147.565 132.312 137.082 1.00 32.42  ? 76  TYR   R N   1 
ATOM   333  C CA  . TYR   A 1 214 ? 146.180 132.208 136.641 1.00 27.57  ? 76  TYR   R CA  1 
ATOM   334  C C   . TYR   A 1 214 ? 145.717 133.491 135.965 1.00 41.32  ? 76  TYR   R C   1 
ATOM   335  O O   . TYR   A 1 214 ? 145.008 133.449 134.951 1.00 54.10  ? 76  TYR   R O   1 
ATOM   336  C CB  . TYR   A 1 214 ? 145.284 131.869 137.825 1.00 37.77  ? 76  TYR   R CB  1 
ATOM   337  C CG  . TYR   A 1 214 ? 145.411 130.444 138.304 1.00 45.72  ? 76  TYR   R CG  1 
ATOM   338  C CD1 . TYR   A 1 214 ? 145.263 129.381 137.427 1.00 43.17  ? 76  TYR   R CD1 1 
ATOM   339  C CD2 . TYR   A 1 214 ? 145.673 130.162 139.636 1.00 41.88  ? 76  TYR   R CD2 1 
ATOM   340  C CE1 . TYR   A 1 214 ? 145.376 128.079 137.863 1.00 41.76  ? 76  TYR   R CE1 1 
ATOM   341  C CE2 . TYR   A 1 214 ? 145.790 128.866 140.079 1.00 37.74  ? 76  TYR   R CE2 1 
ATOM   342  C CZ  . TYR   A 1 214 ? 145.639 127.828 139.190 1.00 43.96  ? 76  TYR   R CZ  1 
ATOM   343  O OH  . TYR   A 1 214 ? 145.753 126.532 139.633 1.00 51.78  ? 76  TYR   R OH  1 
ATOM   344  N N   . ARG   A 1 215 ? 146.112 134.646 136.502 1.00 42.66  ? 77  ARG   R N   1 
ATOM   345  C CA  . ARG   A 1 215 ? 145.718 135.901 135.875 1.00 44.34  ? 77  ARG   R CA  1 
ATOM   346  C C   . ARG   A 1 215 ? 146.449 136.130 134.558 1.00 41.86  ? 77  ARG   R C   1 
ATOM   347  O O   . ARG   A 1 215 ? 145.910 136.789 133.667 1.00 47.50  ? 77  ARG   R O   1 
ATOM   348  C CB  . ARG   A 1 215 ? 145.944 137.065 136.834 1.00 45.57  ? 77  ARG   R CB  1 
ATOM   349  C CG  . ARG   A 1 215 ? 144.878 137.170 137.916 1.00 46.16  ? 77  ARG   R CG  1 
ATOM   350  C CD  . ARG   A 1 215 ? 144.876 138.550 138.535 1.00 46.93  ? 77  ARG   R CD  1 
ATOM   351  N NE  . ARG   A 1 215 ? 143.941 138.673 139.644 1.00 50.16  ? 77  ARG   R NE  1 
ATOM   352  C CZ  . ARG   A 1 215 ? 143.780 139.777 140.359 1.00 49.50  ? 77  ARG   R CZ  1 
ATOM   353  N NH1 . ARG   A 1 215 ? 144.480 140.871 140.108 1.00 44.61  ? 77  ARG   R NH1 1 
ATOM   354  N NH2 . ARG   A 1 215 ? 142.897 139.783 141.353 1.00 48.59  ? 77  ARG   R NH2 1 
ATOM   355  N N   . LEU   A 1 216 ? 147.660 135.594 134.403 1.00 34.45  ? 78  LEU   R N   1 
ATOM   356  C CA  . LEU   A 1 216 ? 148.316 135.648 133.100 1.00 29.75  ? 78  LEU   R CA  1 
ATOM   357  C C   . LEU   A 1 216 ? 147.555 134.823 132.069 1.00 25.73  ? 78  LEU   R C   1 
ATOM   358  O O   . LEU   A 1 216 ? 147.363 135.264 130.928 1.00 39.86  ? 78  LEU   R O   1 
ATOM   359  C CB  . LEU   A 1 216 ? 149.760 135.166 133.212 1.00 30.50  ? 78  LEU   R CB  1 
ATOM   360  C CG  . LEU   A 1 216 ? 150.475 134.931 131.884 1.00 33.16  ? 78  LEU   R CG  1 
ATOM   361  C CD1 . LEU   A 1 216 ? 150.618 136.236 131.132 1.00 36.89  ? 78  LEU   R CD1 1 
ATOM   362  C CD2 . LEU   A 1 216 ? 151.835 134.297 132.112 1.00 38.07  ? 78  LEU   R CD2 1 
ATOM   363  N N   . HIS   A 1 217 ? 147.112 133.624 132.456 1.00 18.46  ? 79  HIS   R N   1 
ATOM   364  C CA  . HIS   A 1 217 ? 146.263 132.830 131.569 1.00 21.00  ? 79  HIS   R CA  1 
ATOM   365  C C   . HIS   A 1 217 ? 145.004 133.604 131.196 1.00 21.05  ? 79  HIS   R C   1 
ATOM   366  O O   . HIS   A 1 217 ? 144.589 133.635 130.027 1.00 38.44  ? 79  HIS   R O   1 
ATOM   367  C CB  . HIS   A 1 217 ? 145.884 131.510 132.244 1.00 28.43  ? 79  HIS   R CB  1 
ATOM   368  C CG  . HIS   A 1 217 ? 146.984 130.497 132.276 1.00 30.97  ? 79  HIS   R CG  1 
ATOM   369  N ND1 . HIS   A 1 217 ? 148.255 130.787 132.720 1.00 35.53  ? 79  HIS   R ND1 1 
ATOM   370  C CD2 . HIS   A 1 217 ? 146.995 129.186 131.937 1.00 26.39  ? 79  HIS   R CD2 1 
ATOM   371  C CE1 . HIS   A 1 217 ? 149.005 129.702 132.641 1.00 34.88  ? 79  HIS   R CE1 1 
ATOM   372  N NE2 . HIS   A 1 217 ? 148.264 128.717 132.170 1.00 34.64  ? 79  HIS   R NE2 1 
ATOM   373  N N   . LEU   A 1 218 ? 144.387 134.241 132.190 1.00 21.10  ? 80  LEU   R N   1 
ATOM   374  C CA  . LEU   A 1 218 ? 143.160 134.994 131.963 1.00 22.64  ? 80  LEU   R CA  1 
ATOM   375  C C   . LEU   A 1 218 ? 143.391 136.172 131.021 1.00 31.13  ? 80  LEU   R C   1 
ATOM   376  O O   . LEU   A 1 218 ? 142.563 136.445 130.145 1.00 34.04  ? 80  LEU   R O   1 
ATOM   377  C CB  . LEU   A 1 218 ? 142.601 135.465 133.305 1.00 22.44  ? 80  LEU   R CB  1 
ATOM   378  C CG  . LEU   A 1 218 ? 141.218 136.101 133.325 1.00 27.25  ? 80  LEU   R CG  1 
ATOM   379  C CD1 . LEU   A 1 218 ? 140.314 135.431 132.325 1.00 30.51  ? 80  LEU   R CD1 1 
ATOM   380  C CD2 . LEU   A 1 218 ? 140.627 136.017 134.718 1.00 26.38  ? 80  LEU   R CD2 1 
ATOM   381  N N   . SER   A 1 219 ? 144.510 136.880 131.186 1.00 33.43  ? 81  SER   R N   1 
ATOM   382  C CA  . SER   A 1 219 ? 144.818 138.006 130.312 1.00 23.68  ? 81  SER   R CA  1 
ATOM   383  C C   . SER   A 1 219 ? 145.087 137.543 128.888 1.00 26.08  ? 81  SER   R C   1 
ATOM   384  O O   . SER   A 1 219 ? 144.691 138.215 127.930 1.00 31.05  ? 81  SER   R O   1 
ATOM   385  C CB  . SER   A 1 219 ? 146.013 138.784 130.857 1.00 29.32  ? 81  SER   R CB  1 
ATOM   386  O OG  . SER   A 1 219 ? 145.644 139.549 131.989 1.00 38.91  ? 81  SER   R OG  1 
ATOM   387  N N   . VAL   A 1 220 ? 145.763 136.404 128.727 1.00 33.86  ? 82  VAL   R N   1 
ATOM   388  C CA  . VAL   A 1 220 ? 145.992 135.866 127.387 1.00 28.07  ? 82  VAL   R CA  1 
ATOM   389  C C   . VAL   A 1 220 ? 144.662 135.569 126.704 1.00 26.99  ? 82  VAL   R C   1 
ATOM   390  O O   . VAL   A 1 220 ? 144.435 135.951 125.547 1.00 45.80  ? 82  VAL   R O   1 
ATOM   391  C CB  . VAL   A 1 220 ? 146.882 134.612 127.454 1.00 20.18  ? 82  VAL   R CB  1 
ATOM   392  C CG1 . VAL   A 1 220 ? 146.761 133.813 126.174 1.00 24.39  ? 82  VAL   R CG1 1 
ATOM   393  C CG2 . VAL   A 1 220 ? 148.326 134.999 127.705 1.00 22.91  ? 82  VAL   R CG2 1 
ATOM   394  N N   . ALA   A 1 221 ? 143.753 134.901 127.419 1.00 11.76  ? 83  ALA   R N   1 
ATOM   395  C CA  . ALA   A 1 221 ? 142.447 134.600 126.837 1.00 10.48  ? 83  ALA   R CA  1 
ATOM   396  C C   . ALA   A 1 221 ? 141.679 135.874 126.499 1.00 25.75  ? 83  ALA   R C   1 
ATOM   397  O O   . ALA   A 1 221 ? 141.074 135.984 125.420 1.00 36.99  ? 83  ALA   R O   1 
ATOM   398  C CB  . ALA   A 1 221 ? 141.638 133.728 127.793 1.00 22.25  ? 83  ALA   R CB  1 
ATOM   399  N N   . ASP   A 1 222 ? 141.699 136.852 127.406 1.00 27.83  ? 84  ASP   R N   1 
ATOM   400  C CA  . ASP   A 1 222 ? 140.947 138.081 127.186 1.00 25.52  ? 84  ASP   R CA  1 
ATOM   401  C C   . ASP   A 1 222 ? 141.480 138.851 125.986 1.00 31.89  ? 84  ASP   R C   1 
ATOM   402  O O   . ASP   A 1 222 ? 140.700 139.382 125.191 1.00 29.05  ? 84  ASP   R O   1 
ATOM   403  C CB  . ASP   A 1 222 ? 140.980 138.949 128.442 1.00 27.45  ? 84  ASP   R CB  1 
ATOM   404  C CG  . ASP   A 1 222 ? 139.981 138.497 129.486 1.00 38.50  ? 84  ASP   R CG  1 
ATOM   405  O OD1 . ASP   A 1 222 ? 139.067 137.719 129.142 1.00 36.21  ? 84  ASP   R OD1 1 
ATOM   406  O OD2 . ASP   A 1 222 ? 140.105 138.925 130.652 1.00 41.82  ? 84  ASP   R OD2 1 
ATOM   407  N N   . LEU   A 1 223 ? 142.804 138.932 125.842 1.00 32.32  ? 85  LEU   R N   1 
ATOM   408  C CA  . LEU   A 1 223 ? 143.378 139.611 124.684 1.00 25.72  ? 85  LEU   R CA  1 
ATOM   409  C C   . LEU   A 1 223 ? 143.045 138.877 123.393 1.00 19.86  ? 85  LEU   R C   1 
ATOM   410  O O   . LEU   A 1 223 ? 142.727 139.510 122.375 1.00 33.63  ? 85  LEU   R O   1 
ATOM   411  C CB  . LEU   A 1 223 ? 144.890 139.741 124.845 1.00 26.57  ? 85  LEU   R CB  1 
ATOM   412  C CG  . LEU   A 1 223 ? 145.660 140.122 123.584 1.00 28.71  ? 85  LEU   R CG  1 
ATOM   413  C CD1 . LEU   A 1 223 ? 145.485 141.593 123.289 1.00 27.51  ? 85  LEU   R CD1 1 
ATOM   414  C CD2 . LEU   A 1 223 ? 147.131 139.783 123.732 1.00 34.55  ? 85  LEU   R CD2 1 
ATOM   415  N N   . LEU   A 1 224 ? 143.112 137.543 123.413 1.00 15.99  ? 86  LEU   R N   1 
ATOM   416  C CA  . LEU   A 1 224 ? 142.767 136.782 122.219 1.00 19.14  ? 86  LEU   R CA  1 
ATOM   417  C C   . LEU   A 1 224 ? 141.331 137.042 121.790 1.00 22.22  ? 86  LEU   R C   1 
ATOM   418  O O   . LEU   A 1 224 ? 141.040 137.074 120.590 1.00 29.05  ? 86  LEU   R O   1 
ATOM   419  C CB  . LEU   A 1 224 ? 142.989 135.290 122.457 1.00 29.73  ? 86  LEU   R CB  1 
ATOM   420  C CG  . LEU   A 1 224 ? 144.130 134.637 121.677 1.00 28.54  ? 86  LEU   R CG  1 
ATOM   421  C CD1 . LEU   A 1 224 ? 143.973 133.128 121.681 1.00 31.38  ? 86  LEU   R CD1 1 
ATOM   422  C CD2 . LEU   A 1 224 ? 144.188 135.165 120.255 1.00 31.94  ? 86  LEU   R CD2 1 
ATOM   423  N N   . PHE   A 1 225 ? 140.419 137.224 122.746 1.00 18.13  ? 87  PHE   R N   1 
ATOM   424  C CA  . PHE   A 1 225 ? 139.053 137.571 122.357 1.00 18.45  ? 87  PHE   R CA  1 
ATOM   425  C C   . PHE   A 1 225 ? 138.930 139.024 121.906 1.00 27.95  ? 87  PHE   R C   1 
ATOM   426  O O   . PHE   A 1 225 ? 138.216 139.314 120.940 1.00 33.97  ? 87  PHE   R O   1 
ATOM   427  C CB  . PHE   A 1 225 ? 138.083 137.309 123.499 1.00 31.76  ? 87  PHE   R CB  1 
ATOM   428  C CG  . PHE   A 1 225 ? 136.748 137.968 123.315 1.00 23.67  ? 87  PHE   R CG  1 
ATOM   429  C CD1 . PHE   A 1 225 ? 135.900 137.569 122.299 1.00 21.93  ? 87  PHE   R CD1 1 
ATOM   430  C CD2 . PHE   A 1 225 ? 136.344 138.989 124.153 1.00 21.30  ? 87  PHE   R CD2 1 
ATOM   431  C CE1 . PHE   A 1 225 ? 134.672 138.172 122.127 1.00 20.87  ? 87  PHE   R CE1 1 
ATOM   432  C CE2 . PHE   A 1 225 ? 135.117 139.594 123.985 1.00 27.24  ? 87  PHE   R CE2 1 
ATOM   433  C CZ  . PHE   A 1 225 ? 134.282 139.185 122.970 1.00 28.32  ? 87  PHE   R CZ  1 
ATOM   434  N N   . VAL   A 1 226 ? 139.601 139.949 122.600 1.00 29.08  ? 88  VAL   R N   1 
ATOM   435  C CA  . VAL   A 1 226 ? 139.478 141.374 122.295 1.00 21.19  ? 88  VAL   R CA  1 
ATOM   436  C C   . VAL   A 1 226 ? 140.016 141.683 120.906 1.00 23.37  ? 88  VAL   R C   1 
ATOM   437  O O   . VAL   A 1 226 ? 139.566 142.633 120.254 1.00 30.88  ? 88  VAL   R O   1 
ATOM   438  C CB  . VAL   A 1 226 ? 140.183 142.203 123.386 1.00 16.16  ? 88  VAL   R CB  1 
ATOM   439  C CG1 . VAL   A 1 226 ? 140.490 143.604 122.903 1.00 26.20  ? 88  VAL   R CG1 1 
ATOM   440  C CG2 . VAL   A 1 226 ? 139.323 142.265 124.630 1.00 30.98  ? 88  VAL   R CG2 1 
ATOM   441  N N   . ILE   A 1 227 ? 140.955 140.878 120.416 1.00 32.04  ? 89  ILE   R N   1 
ATOM   442  C CA  . ILE   A 1 227 ? 141.516 141.053 119.079 1.00 17.57  ? 89  ILE   R CA  1 
ATOM   443  C C   . ILE   A 1 227 ? 140.421 141.088 118.013 1.00 20.87  ? 89  ILE   R C   1 
ATOM   444  O O   . ILE   A 1 227 ? 140.564 141.762 116.986 1.00 36.17  ? 89  ILE   R O   1 
ATOM   445  C CB  . ILE   A 1 227 ? 142.546 139.941 118.792 1.00 26.42  ? 89  ILE   R CB  1 
ATOM   446  C CG1 . ILE   A 1 227 ? 143.933 140.364 119.278 1.00 36.95  ? 89  ILE   R CG1 1 
ATOM   447  C CG2 . ILE   A 1 227 ? 142.579 139.563 117.320 1.00 29.76  ? 89  ILE   R CG2 1 
ATOM   448  C CD1 . ILE   A 1 227 ? 144.490 141.567 118.561 1.00 33.60  ? 89  ILE   R CD1 1 
ATOM   449  N N   . THR   A 1 228 ? 139.302 140.407 118.261 1.00 15.40  ? 90  THR   R N   1 
ATOM   450  C CA  . THR   A 1 228 ? 138.269 140.206 117.251 1.00 24.57  ? 90  THR   R CA  1 
ATOM   451  C C   . THR   A 1 228 ? 137.084 141.160 117.378 1.00 24.80  ? 90  THR   R C   1 
ATOM   452  O O   . THR   A 1 228 ? 136.009 140.860 116.850 1.00 24.53  ? 90  THR   R O   1 
ATOM   453  C CB  . THR   A 1 228 ? 137.761 138.764 117.299 1.00 30.95  ? 90  THR   R CB  1 
ATOM   454  O OG1 . THR   A 1 228 ? 136.677 138.670 118.230 1.00 34.35  ? 90  THR   R OG1 1 
ATOM   455  C CG2 . THR   A 1 228 ? 138.873 137.824 117.731 1.00 31.72  ? 90  THR   R CG2 1 
ATOM   456  N N   . LEU   A 1 229 ? 137.237 142.286 118.067 1.00 26.64  ? 91  LEU   R N   1 
ATOM   457  C CA  . LEU   A 1 229 ? 136.124 143.218 118.237 1.00 19.00  ? 91  LEU   R CA  1 
ATOM   458  C C   . LEU   A 1 229 ? 135.891 144.152 117.047 1.00 27.80  ? 91  LEU   R C   1 
ATOM   459  O O   . LEU   A 1 229 ? 134.729 144.466 116.752 1.00 41.94  ? 91  LEU   R O   1 
ATOM   460  C CB  . LEU   A 1 229 ? 136.314 144.040 119.513 1.00 21.18  ? 91  LEU   R CB  1 
ATOM   461  C CG  . LEU   A 1 229 ? 135.693 143.397 120.756 1.00 23.11  ? 91  LEU   R CG  1 
ATOM   462  C CD1 . LEU   A 1 229 ? 135.740 144.340 121.938 1.00 29.27  ? 91  LEU   R CD1 1 
ATOM   463  C CD2 . LEU   A 1 229 ? 134.270 142.955 120.481 1.00 25.18  ? 91  LEU   R CD2 1 
ATOM   464  N N   . PRO   A 1 230 ? 136.929 144.649 116.359 1.00 27.48  ? 92  PRO   R N   1 
ATOM   465  C CA  . PRO   A 1 230 ? 136.664 145.504 115.189 1.00 26.54  ? 92  PRO   R CA  1 
ATOM   466  C C   . PRO   A 1 230 ? 135.808 144.844 114.124 1.00 34.90  ? 92  PRO   R C   1 
ATOM   467  O O   . PRO   A 1 230 ? 135.011 145.531 113.473 1.00 37.76  ? 92  PRO   R O   1 
ATOM   468  C CB  . PRO   A 1 230 ? 138.068 145.817 114.664 1.00 27.73  ? 92  PRO   R CB  1 
ATOM   469  C CG  . PRO   A 1 230 ? 138.914 145.765 115.857 1.00 33.49  ? 92  PRO   R CG  1 
ATOM   470  C CD  . PRO   A 1 230 ? 138.360 144.668 116.711 1.00 31.09  ? 92  PRO   R CD  1 
ATOM   471  N N   . PHE   A 1 231 ? 135.947 143.532 113.922 1.00 41.25  ? 93  PHE   R N   1 
ATOM   472  C CA  . PHE   A 1 231 ? 135.094 142.841 112.961 1.00 35.00  ? 93  PHE   R CA  1 
ATOM   473  C C   . PHE   A 1 231 ? 133.629 142.944 113.360 1.00 34.10  ? 93  PHE   R C   1 
ATOM   474  O O   . PHE   A 1 231 ? 132.763 143.194 112.515 1.00 31.89  ? 93  PHE   R O   1 
ATOM   475  C CB  . PHE   A 1 231 ? 135.517 141.378 112.837 1.00 32.61  ? 93  PHE   R CB  1 
ATOM   476  C CG  . PHE   A 1 231 ? 136.934 141.197 112.379 1.00 36.42  ? 93  PHE   R CG  1 
ATOM   477  C CD1 . PHE   A 1 231 ? 137.976 141.182 113.290 1.00 37.78  ? 93  PHE   R CD1 1 
ATOM   478  C CD2 . PHE   A 1 231 ? 137.226 141.047 111.037 1.00 40.96  ? 93  PHE   R CD2 1 
ATOM   479  C CE1 . PHE   A 1 231 ? 139.280 141.020 112.870 1.00 32.84  ? 93  PHE   R CE1 1 
ATOM   480  C CE2 . PHE   A 1 231 ? 138.529 140.884 110.611 1.00 41.09  ? 93  PHE   R CE2 1 
ATOM   481  C CZ  . PHE   A 1 231 ? 139.557 140.871 111.530 1.00 38.80  ? 93  PHE   R CZ  1 
ATOM   482  N N   . TRP   A 1 232 ? 133.335 142.778 114.651 1.00 31.47  ? 94  TRP   R N   1 
ATOM   483  C CA  . TRP   A 1 232 ? 131.957 142.884 115.115 1.00 29.67  ? 94  TRP   R CA  1 
ATOM   484  C C   . TRP   A 1 232 ? 131.452 144.319 115.036 1.00 39.59  ? 94  TRP   R C   1 
ATOM   485  O O   . TRP   A 1 232 ? 130.276 144.551 114.735 1.00 47.94  ? 94  TRP   R O   1 
ATOM   486  C CB  . TRP   A 1 232 ? 131.844 142.343 116.537 1.00 30.65  ? 94  TRP   R CB  1 
ATOM   487  C CG  . TRP   A 1 232 ? 132.028 140.866 116.604 1.00 31.84  ? 94  TRP   R CG  1 
ATOM   488  C CD1 . TRP   A 1 232 ? 133.045 140.194 117.209 1.00 34.81  ? 94  TRP   R CD1 1 
ATOM   489  C CD2 . TRP   A 1 232 ? 131.174 139.871 116.031 1.00 37.24  ? 94  TRP   R CD2 1 
ATOM   490  N NE1 . TRP   A 1 232 ? 132.877 138.841 117.055 1.00 33.76  ? 94  TRP   R NE1 1 
ATOM   491  C CE2 . TRP   A 1 232 ? 131.733 138.617 116.335 1.00 36.40  ? 94  TRP   R CE2 1 
ATOM   492  C CE3 . TRP   A 1 232 ? 129.989 139.918 115.294 1.00 40.50  ? 94  TRP   R CE3 1 
ATOM   493  C CZ2 . TRP   A 1 232 ? 131.149 137.424 115.928 1.00 41.56  ? 94  TRP   R CZ2 1 
ATOM   494  C CZ3 . TRP   A 1 232 ? 129.412 138.734 114.891 1.00 34.72  ? 94  TRP   R CZ3 1 
ATOM   495  C CH2 . TRP   A 1 232 ? 129.991 137.504 115.208 1.00 38.56  ? 94  TRP   R CH2 1 
ATOM   496  N N   . ALA   A 1 233 ? 132.323 145.297 115.293 1.00 35.18  ? 95  ALA   R N   1 
ATOM   497  C CA  . ALA   A 1 233 ? 131.919 146.693 115.146 1.00 28.44  ? 95  ALA   R CA  1 
ATOM   498  C C   . ALA   A 1 233 ? 131.547 147.006 113.701 1.00 32.89  ? 95  ALA   R C   1 
ATOM   499  O O   . ALA   A 1 233 ? 130.517 147.639 113.433 1.00 37.11  ? 95  ALA   R O   1 
ATOM   500  C CB  . ALA   A 1 233 ? 133.037 147.616 115.628 1.00 25.80  ? 95  ALA   R CB  1 
ATOM   501  N N   . VAL   A 1 234 ? 132.368 146.552 112.752 1.00 39.49  ? 96  VAL   R N   1 
ATOM   502  C CA  . VAL   A 1 234 ? 132.082 146.794 111.341 1.00 36.65  ? 96  VAL   R CA  1 
ATOM   503  C C   . VAL   A 1 234 ? 130.831 146.038 110.909 1.00 39.69  ? 96  VAL   R C   1 
ATOM   504  O O   . VAL   A 1 234 ? 130.045 146.530 110.092 1.00 43.70  ? 96  VAL   R O   1 
ATOM   505  C CB  . VAL   A 1 234 ? 133.301 146.425 110.477 1.00 36.05  ? 96  VAL   R CB  1 
ATOM   506  C CG1 . VAL   A 1 234 ? 132.971 146.560 109.003 1.00 34.31  ? 96  VAL   R CG1 1 
ATOM   507  C CG2 . VAL   A 1 234 ? 134.481 147.304 110.834 1.00 40.52  ? 96  VAL   R CG2 1 
ATOM   508  N N   . ASP   A 1 235 ? 130.624 144.832 111.445 1.00 47.09  ? 97  ASP   R N   1 
ATOM   509  C CA  . ASP   A 1 235 ? 129.399 144.097 111.149 1.00 49.12  ? 97  ASP   R CA  1 
ATOM   510  C C   . ASP   A 1 235 ? 128.173 144.850 111.648 1.00 49.01  ? 97  ASP   R C   1 
ATOM   511  O O   . ASP   A 1 235 ? 127.142 144.896 110.967 1.00 48.18  ? 97  ASP   R O   1 
ATOM   512  C CB  . ASP   A 1 235 ? 129.456 142.703 111.773 1.00 48.93  ? 97  ASP   R CB  1 
ATOM   513  C CG  . ASP   A 1 235 ? 128.147 141.946 111.634 1.00 50.76  ? 97  ASP   R CG  1 
ATOM   514  O OD1 . ASP   A 1 235 ? 127.500 142.056 110.573 1.00 54.15  ? 97  ASP   R OD1 1 
ATOM   515  O OD2 . ASP   A 1 235 ? 127.760 141.243 112.590 1.00 48.37  ? 97  ASP   R OD2 1 
ATOM   516  N N   . ALA   A 1 236 ? 128.264 145.438 112.842 1.00 44.26  ? 98  ALA   R N   1 
ATOM   517  C CA  . ALA   A 1 236 ? 127.142 146.200 113.376 1.00 41.10  ? 98  ALA   R CA  1 
ATOM   518  C C   . ALA   A 1 236 ? 126.885 147.458 112.558 1.00 40.88  ? 98  ALA   R C   1 
ATOM   519  O O   . ALA   A 1 236 ? 125.728 147.841 112.349 1.00 45.67  ? 98  ALA   R O   1 
ATOM   520  C CB  . ALA   A 1 236 ? 127.397 146.555 114.839 1.00 40.06  ? 98  ALA   R CB  1 
ATOM   521  N N   . VAL   A 1 237 ? 127.943 148.113 112.084 1.00 43.20  ? 99  VAL   R N   1 
ATOM   522  C CA  . VAL   A 1 237 ? 127.769 149.383 111.383 1.00 39.37  ? 99  VAL   R CA  1 
ATOM   523  C C   . VAL   A 1 237 ? 127.225 149.160 109.977 1.00 43.87  ? 99  VAL   R C   1 
ATOM   524  O O   . VAL   A 1 237 ? 126.115 149.593 109.649 1.00 48.83  ? 99  VAL   R O   1 
ATOM   525  C CB  . VAL   A 1 237 ? 129.092 150.168 111.343 1.00 46.16  ? 99  VAL   R CB  1 
ATOM   526  C CG1 . VAL   A 1 237 ? 128.979 151.343 110.386 1.00 49.19  ? 99  VAL   R CG1 1 
ATOM   527  C CG2 . VAL   A 1 237 ? 129.465 150.651 112.722 1.00 49.55  ? 99  VAL   R CG2 1 
ATOM   528  N N   . ALA   A 1 238 ? 127.997 148.483 109.124 1.00 54.41  ? 100 ALA   R N   1 
ATOM   529  C CA  . ALA   A 1 238 ? 127.681 148.431 107.701 1.00 55.90  ? 100 ALA   R CA  1 
ATOM   530  C C   . ALA   A 1 238 ? 127.378 147.026 107.198 1.00 57.64  ? 100 ALA   R C   1 
ATOM   531  O O   . ALA   A 1 238 ? 126.272 146.785 106.705 1.00 59.34  ? 100 ALA   R O   1 
ATOM   532  C CB  . ALA   A 1 238 ? 128.836 149.044 106.899 1.00 52.09  ? 100 ALA   R CB  1 
ATOM   533  N N   . ASN   A 1 239 ? 128.311 146.088 107.320 1.00 63.84  ? 101 ASN   R N   1 
ATOM   534  C CA  . ASN   A 1 239 ? 128.212 144.807 106.625 1.00 64.16  ? 101 ASN   R CA  1 
ATOM   535  C C   . ASN   A 1 239 ? 129.339 143.904 107.114 1.00 63.15  ? 101 ASN   R C   1 
ATOM   536  O O   . ASN   A 1 239 ? 130.147 144.289 107.965 1.00 62.52  ? 101 ASN   R O   1 
ATOM   537  C CB  . ASN   A 1 239 ? 128.269 145.008 105.109 1.00 62.13  ? 101 ASN   R CB  1 
ATOM   538  C CG  . ASN   A 1 239 ? 127.652 143.860 104.340 1.00 66.13  ? 101 ASN   R CG  1 
ATOM   539  O OD1 . ASN   A 1 239 ? 127.375 142.800 104.899 1.00 71.62  ? 101 ASN   R OD1 1 
ATOM   540  N ND2 . ASN   A 1 239 ? 127.436 144.065 103.046 1.00 63.04  ? 101 ASN   R ND2 1 
ATOM   541  N N   . TRP   A 1 240 ? 129.385 142.692 106.566 1.00 58.25  ? 102 TRP   R N   1 
ATOM   542  C CA  . TRP   A 1 240 ? 130.428 141.712 106.862 1.00 53.99  ? 102 TRP   R CA  1 
ATOM   543  C C   . TRP   A 1 240 ? 131.087 141.326 105.541 1.00 56.57  ? 102 TRP   R C   1 
ATOM   544  O O   . TRP   A 1 240 ? 130.540 140.522 104.781 1.00 54.08  ? 102 TRP   R O   1 
ATOM   545  C CB  . TRP   A 1 240 ? 129.849 140.492 107.574 1.00 49.41  ? 102 TRP   R CB  1 
ATOM   546  C CG  . TRP   A 1 240 ? 130.876 139.468 107.961 1.00 48.07  ? 102 TRP   R CG  1 
ATOM   547  C CD1 . TRP   A 1 240 ? 131.410 138.501 107.164 1.00 52.28  ? 102 TRP   R CD1 1 
ATOM   548  C CD2 . TRP   A 1 240 ? 131.479 139.303 109.249 1.00 52.20  ? 102 TRP   R CD2 1 
ATOM   549  N NE1 . TRP   A 1 240 ? 132.316 137.751 107.871 1.00 50.99  ? 102 TRP   R NE1 1 
ATOM   550  C CE2 . TRP   A 1 240 ? 132.375 138.224 109.155 1.00 48.06  ? 102 TRP   R CE2 1 
ATOM   551  C CE3 . TRP   A 1 240 ? 131.351 139.967 110.471 1.00 56.49  ? 102 TRP   R CE3 1 
ATOM   552  C CZ2 . TRP   A 1 240 ? 133.138 137.794 110.233 1.00 51.15  ? 102 TRP   R CZ2 1 
ATOM   553  C CZ3 . TRP   A 1 240 ? 132.110 139.538 111.540 1.00 51.48  ? 102 TRP   R CZ3 1 
ATOM   554  C CH2 . TRP   A 1 240 ? 132.991 138.463 111.415 1.00 47.51  ? 102 TRP   R CH2 1 
ATOM   555  N N   . TYR   A 1 241 ? 132.261 141.897 105.265 1.00 65.09  ? 103 TYR   R N   1 
ATOM   556  C CA  . TYR   A 1 241 ? 133.010 141.611 104.049 1.00 64.76  ? 103 TYR   R CA  1 
ATOM   557  C C   . TYR   A 1 241 ? 134.168 140.649 104.287 1.00 68.68  ? 103 TYR   R C   1 
ATOM   558  O O   . TYR   A 1 241 ? 135.109 140.617 103.488 1.00 70.64  ? 103 TYR   R O   1 
ATOM   559  C CB  . TYR   A 1 241 ? 133.558 142.901 103.435 1.00 64.57  ? 103 TYR   R CB  1 
ATOM   560  C CG  . TYR   A 1 241 ? 132.674 144.118 103.558 1.00 67.70  ? 103 TYR   R CG  1 
ATOM   561  C CD1 . TYR   A 1 241 ? 131.560 144.277 102.748 1.00 67.31  ? 103 TYR   R CD1 1 
ATOM   562  C CD2 . TYR   A 1 241 ? 132.973 145.124 104.467 1.00 66.75  ? 103 TYR   R CD2 1 
ATOM   563  C CE1 . TYR   A 1 241 ? 130.762 145.397 102.847 1.00 66.24  ? 103 TYR   R CE1 1 
ATOM   564  C CE2 . TYR   A 1 241 ? 132.179 146.245 104.577 1.00 67.14  ? 103 TYR   R CE2 1 
ATOM   565  C CZ  . TYR   A 1 241 ? 131.075 146.377 103.766 1.00 70.24  ? 103 TYR   R CZ  1 
ATOM   566  O OH  . TYR   A 1 241 ? 130.281 147.494 103.873 1.00 72.50  ? 103 TYR   R OH  1 
ATOM   567  N N   . PHE   A 1 242 ? 134.124 139.869 105.364 1.00 56.76  ? 104 PHE   R N   1 
ATOM   568  C CA  . PHE   A 1 242 ? 135.301 139.145 105.833 1.00 52.18  ? 104 PHE   R CA  1 
ATOM   569  C C   . PHE   A 1 242 ? 135.334 137.694 105.359 1.00 53.58  ? 104 PHE   R C   1 
ATOM   570  O O   . PHE   A 1 242 ? 136.330 137.258 104.776 1.00 58.83  ? 104 PHE   R O   1 
ATOM   571  C CB  . PHE   A 1 242 ? 135.368 139.249 107.359 1.00 51.82  ? 104 PHE   R CB  1 
ATOM   572  C CG  . PHE   A 1 242 ? 135.299 140.664 107.855 1.00 52.37  ? 104 PHE   R CG  1 
ATOM   573  C CD1 . PHE   A 1 242 ? 136.374 141.518 107.694 1.00 52.82  ? 104 PHE   R CD1 1 
ATOM   574  C CD2 . PHE   A 1 242 ? 134.155 141.148 108.460 1.00 54.48  ? 104 PHE   R CD2 1 
ATOM   575  C CE1 . PHE   A 1 242 ? 136.312 142.822 108.139 1.00 51.43  ? 104 PHE   R CE1 1 
ATOM   576  C CE2 . PHE   A 1 242 ? 134.089 142.451 108.907 1.00 50.91  ? 104 PHE   R CE2 1 
ATOM   577  C CZ  . PHE   A 1 242 ? 135.168 143.287 108.747 1.00 48.03  ? 104 PHE   R CZ  1 
ATOM   578  N N   . GLY   A 1 243 ? 134.274 136.933 105.600 1.00 55.42  ? 105 GLY   R N   1 
ATOM   579  C CA  . GLY   A 1 243 ? 134.143 135.614 105.014 1.00 53.43  ? 105 GLY   R CA  1 
ATOM   580  C C   . GLY   A 1 243 ? 133.801 134.549 106.039 1.00 64.48  ? 105 GLY   R C   1 
ATOM   581  O O   . GLY   A 1 243 ? 133.798 134.772 107.249 1.00 67.39  ? 105 GLY   R O   1 
ATOM   582  N N   . ASN   A 1 244 ? 133.518 133.356 105.506 1.00 59.15  ? 106 ASN   R N   1 
ATOM   583  C CA  . ASN   A 1 244 ? 133.105 132.228 106.335 1.00 55.64  ? 106 ASN   R CA  1 
ATOM   584  C C   . ASN   A 1 244 ? 134.209 131.807 107.294 1.00 54.16  ? 106 ASN   R C   1 
ATOM   585  O O   . ASN   A 1 244 ? 133.943 131.490 108.462 1.00 60.30  ? 106 ASN   R O   1 
ATOM   586  C CB  . ASN   A 1 244 ? 132.698 131.057 105.443 1.00 51.80  ? 106 ASN   R CB  1 
ATOM   587  C CG  . ASN   A 1 244 ? 131.562 130.252 106.026 1.00 59.49  ? 106 ASN   R CG  1 
ATOM   588  O OD1 . ASN   A 1 244 ? 131.110 130.516 107.138 1.00 63.77  ? 106 ASN   R OD1 1 
ATOM   589  N ND2 . ASN   A 1 244 ? 131.093 129.261 105.279 1.00 60.52  ? 106 ASN   R ND2 1 
ATOM   590  N N   . PHE   A 1 245 ? 135.454 131.786 106.816 1.00 46.70  ? 107 PHE   R N   1 
ATOM   591  C CA  . PHE   A 1 245 ? 136.566 131.393 107.672 1.00 48.19  ? 107 PHE   R CA  1 
ATOM   592  C C   . PHE   A 1 245 ? 136.712 132.344 108.852 1.00 57.25  ? 107 PHE   R C   1 
ATOM   593  O O   . PHE   A 1 245 ? 136.904 131.906 109.993 1.00 63.62  ? 107 PHE   R O   1 
ATOM   594  C CB  . PHE   A 1 245 ? 137.856 131.342 106.857 1.00 50.23  ? 107 PHE   R CB  1 
ATOM   595  C CG  . PHE   A 1 245 ? 139.053 130.911 107.645 1.00 54.29  ? 107 PHE   R CG  1 
ATOM   596  C CD1 . PHE   A 1 245 ? 139.280 129.572 107.903 1.00 53.11  ? 107 PHE   R CD1 1 
ATOM   597  C CD2 . PHE   A 1 245 ? 139.952 131.845 108.131 1.00 56.59  ? 107 PHE   R CD2 1 
ATOM   598  C CE1 . PHE   A 1 245 ? 140.383 129.171 108.630 1.00 53.35  ? 107 PHE   R CE1 1 
ATOM   599  C CE2 . PHE   A 1 245 ? 141.056 131.450 108.860 1.00 56.02  ? 107 PHE   R CE2 1 
ATOM   600  C CZ  . PHE   A 1 245 ? 141.271 130.111 109.109 1.00 54.25  ? 107 PHE   R CZ  1 
ATOM   601  N N   . LEU   A 1 246 ? 136.603 133.651 108.604 1.00 52.63  ? 108 LEU   R N   1 
ATOM   602  C CA  . LEU   A 1 246 ? 136.733 134.615 109.692 1.00 47.96  ? 108 LEU   R CA  1 
ATOM   603  C C   . LEU   A 1 246 ? 135.540 134.552 110.636 1.00 50.40  ? 108 LEU   R C   1 
ATOM   604  O O   . LEU   A 1 246 ? 135.698 134.726 111.849 1.00 59.05  ? 108 LEU   R O   1 
ATOM   605  C CB  . LEU   A 1 246 ? 136.913 136.023 109.133 1.00 46.36  ? 108 LEU   R CB  1 
ATOM   606  C CG  . LEU   A 1 246 ? 138.379 136.402 108.909 1.00 53.10  ? 108 LEU   R CG  1 
ATOM   607  C CD1 . LEU   A 1 246 ? 138.520 137.858 108.499 1.00 55.30  ? 108 LEU   R CD1 1 
ATOM   608  C CD2 . LEU   A 1 246 ? 139.203 136.112 110.153 1.00 47.99  ? 108 LEU   R CD2 1 
ATOM   609  N N   . CYS   A 1 247 ? 134.342 134.300 110.103 1.00 38.81  ? 109 CYS   R N   1 
ATOM   610  C CA  . CYS   A 1 247 ? 133.177 134.114 110.965 1.00 43.98  ? 109 CYS   R CA  1 
ATOM   611  C C   . CYS   A 1 247 ? 133.393 132.950 111.927 1.00 48.70  ? 109 CYS   R C   1 
ATOM   612  O O   . CYS   A 1 247 ? 133.198 133.080 113.146 1.00 52.37  ? 109 CYS   R O   1 
ATOM   613  C CB  . CYS   A 1 247 ? 131.932 133.884 110.108 1.00 39.92  ? 109 CYS   R CB  1 
ATOM   614  S SG  . CYS   A 1 247 ? 130.352 133.974 110.980 1.00 72.31  ? 109 CYS   R SG  1 
ATOM   615  N N   . LYS   A 1 248 ? 133.820 131.803 111.393 1.00 43.37  ? 110 LYS   R N   1 
ATOM   616  C CA  . LYS   A 1 248 ? 134.074 130.645 112.243 1.00 36.92  ? 110 LYS   R CA  1 
ATOM   617  C C   . LYS   A 1 248 ? 135.176 130.936 113.251 1.00 37.31  ? 110 LYS   R C   1 
ATOM   618  O O   . LYS   A 1 248 ? 135.073 130.554 114.423 1.00 42.86  ? 110 LYS   R O   1 
ATOM   619  C CB  . LYS   A 1 248 ? 134.435 129.430 111.388 1.00 30.99  ? 110 LYS   R CB  1 
ATOM   620  C CG  . LYS   A 1 248 ? 133.262 128.832 110.629 1.00 35.07  ? 110 LYS   R CG  1 
ATOM   621  C CD  . LYS   A 1 248 ? 133.664 127.550 109.924 1.00 35.59  ? 110 LYS   R CD  1 
ATOM   622  C CE  . LYS   A 1 248 ? 132.726 127.235 108.774 1.00 34.74  ? 110 LYS   R CE  1 
ATOM   623  N NZ  . LYS   A 1 248 ? 131.317 127.105 109.220 1.00 34.00  ? 110 LYS   R NZ  1 
ATOM   624  N N   . ALA   A 1 249 ? 136.237 131.621 112.816 1.00 23.11  ? 111 ALA   R N   1 
ATOM   625  C CA  . ALA   A 1 249 ? 137.349 131.908 113.714 1.00 21.28  ? 111 ALA   R CA  1 
ATOM   626  C C   . ALA   A 1 249 ? 136.916 132.790 114.878 1.00 28.47  ? 111 ALA   R C   1 
ATOM   627  O O   . ALA   A 1 249 ? 137.271 132.521 116.033 1.00 29.36  ? 111 ALA   R O   1 
ATOM   628  C CB  . ALA   A 1 249 ? 138.490 132.565 112.940 1.00 21.63  ? 111 ALA   R CB  1 
ATOM   629  N N   . VAL   A 1 250 ? 136.145 133.844 114.603 1.00 33.53  ? 112 VAL   R N   1 
ATOM   630  C CA  . VAL   A 1 250 ? 135.754 134.746 115.682 1.00 31.86  ? 112 VAL   R CA  1 
ATOM   631  C C   . VAL   A 1 250 ? 134.778 134.058 116.630 1.00 35.49  ? 112 VAL   R C   1 
ATOM   632  O O   . VAL   A 1 250 ? 134.855 134.243 117.852 1.00 38.23  ? 112 VAL   R O   1 
ATOM   633  C CB  . VAL   A 1 250 ? 135.193 136.071 115.127 1.00 22.04  ? 112 VAL   R CB  1 
ATOM   634  C CG1 . VAL   A 1 250 ? 136.263 136.806 114.337 1.00 19.68  ? 112 VAL   R CG1 1 
ATOM   635  C CG2 . VAL   A 1 250 ? 133.962 135.844 114.278 1.00 25.07  ? 112 VAL   R CG2 1 
ATOM   636  N N   . HIS   A 1 251 ? 133.864 133.235 116.100 1.00 35.38  ? 113 HIS   R N   1 
ATOM   637  C CA  . HIS   A 1 251 ? 132.968 132.496 116.989 1.00 27.05  ? 113 HIS   R CA  1 
ATOM   638  C C   . HIS   A 1 251 ? 133.744 131.539 117.891 1.00 27.26  ? 113 HIS   R C   1 
ATOM   639  O O   . HIS   A 1 251 ? 133.469 131.440 119.098 1.00 28.69  ? 113 HIS   R O   1 
ATOM   640  C CB  . HIS   A 1 251 ? 131.928 131.734 116.172 1.00 23.42  ? 113 HIS   R CB  1 
ATOM   641  C CG  . HIS   A 1 251 ? 130.722 132.546 115.818 1.00 29.79  ? 113 HIS   R CG  1 
ATOM   642  N ND1 . HIS   A 1 251 ? 130.633 133.279 114.655 1.00 30.86  ? 113 HIS   R ND1 1 
ATOM   643  C CD2 . HIS   A 1 251 ? 129.551 132.732 116.470 1.00 36.10  ? 113 HIS   R CD2 1 
ATOM   644  C CE1 . HIS   A 1 251 ? 129.460 133.885 114.608 1.00 27.04  ? 113 HIS   R CE1 1 
ATOM   645  N NE2 . HIS   A 1 251 ? 128.785 133.569 115.697 1.00 31.56  ? 113 HIS   R NE2 1 
ATOM   646  N N   . VAL   A 1 252 ? 134.725 130.832 117.325 1.00 30.38  ? 114 VAL   R N   1 
ATOM   647  C CA  . VAL   A 1 252 ? 135.518 129.891 118.110 1.00 25.42  ? 114 VAL   R CA  1 
ATOM   648  C C   . VAL   A 1 252 ? 136.291 130.621 119.200 1.00 25.99  ? 114 VAL   R C   1 
ATOM   649  O O   . VAL   A 1 252 ? 136.352 130.165 120.350 1.00 33.88  ? 114 VAL   R O   1 
ATOM   650  C CB  . VAL   A 1 252 ? 136.455 129.095 117.183 1.00 23.20  ? 114 VAL   R CB  1 
ATOM   651  C CG1 . VAL   A 1 252 ? 137.587 128.464 117.973 1.00 29.13  ? 114 VAL   R CG1 1 
ATOM   652  C CG2 . VAL   A 1 252 ? 135.670 128.044 116.425 1.00 16.62  ? 114 VAL   R CG2 1 
ATOM   653  N N   . ILE   A 1 253 ? 136.896 131.761 118.856 1.00 20.18  ? 115 ILE   R N   1 
ATOM   654  C CA  . ILE   A 1 253 ? 137.662 132.521 119.839 1.00 15.06  ? 115 ILE   R CA  1 
ATOM   655  C C   . ILE   A 1 253 ? 136.755 133.008 120.960 1.00 23.31  ? 115 ILE   R C   1 
ATOM   656  O O   . ILE   A 1 253 ? 137.124 132.970 122.143 1.00 29.78  ? 115 ILE   R O   1 
ATOM   657  C CB  . ILE   A 1 253 ? 138.396 133.687 119.155 1.00 26.98  ? 115 ILE   R CB  1 
ATOM   658  C CG1 . ILE   A 1 253 ? 139.468 133.153 118.207 1.00 27.04  ? 115 ILE   R CG1 1 
ATOM   659  C CG2 . ILE   A 1 253 ? 139.022 134.596 120.188 1.00 28.94  ? 115 ILE   R CG2 1 
ATOM   660  C CD1 . ILE   A 1 253 ? 140.012 134.192 117.261 1.00 24.31  ? 115 ILE   R CD1 1 
ATOM   661  N N   . TYR   A 1 254 ? 135.551 133.466 120.608 1.00 31.38  ? 116 TYR   R N   1 
ATOM   662  C CA  . TYR   A 1 254 ? 134.595 133.896 121.622 1.00 21.58  ? 116 TYR   R CA  1 
ATOM   663  C C   . TYR   A 1 254 ? 134.273 132.768 122.591 1.00 31.87  ? 116 TYR   R C   1 
ATOM   664  O O   . TYR   A 1 254 ? 134.305 132.959 123.812 1.00 44.52  ? 116 TYR   R O   1 
ATOM   665  C CB  . TYR   A 1 254 ? 133.323 134.405 120.951 1.00 24.77  ? 116 TYR   R CB  1 
ATOM   666  C CG  . TYR   A 1 254 ? 132.150 134.574 121.886 1.00 28.19  ? 116 TYR   R CG  1 
ATOM   667  C CD1 . TYR   A 1 254 ? 132.103 135.622 122.792 1.00 33.06  ? 116 TYR   R CD1 1 
ATOM   668  C CD2 . TYR   A 1 254 ? 131.079 133.694 121.849 1.00 29.19  ? 116 TYR   R CD2 1 
ATOM   669  C CE1 . TYR   A 1 254 ? 131.026 135.785 123.642 1.00 31.54  ? 116 TYR   R CE1 1 
ATOM   670  C CE2 . TYR   A 1 254 ? 129.996 133.851 122.693 1.00 28.25  ? 116 TYR   R CE2 1 
ATOM   671  C CZ  . TYR   A 1 254 ? 129.976 134.897 123.586 1.00 29.70  ? 116 TYR   R CZ  1 
ATOM   672  O OH  . TYR   A 1 254 ? 128.901 135.052 124.427 1.00 39.64  ? 116 TYR   R OH  1 
ATOM   673  N N   . THR   A 1 255 ? 133.962 131.579 122.065 1.00 33.91  ? 117 THR   R N   1 
ATOM   674  C CA  . THR   A 1 255 ? 133.613 130.460 122.943 1.00 25.21  ? 117 THR   R CA  1 
ATOM   675  C C   . THR   A 1 255 ? 134.780 130.068 123.844 1.00 21.21  ? 117 THR   R C   1 
ATOM   676  O O   . THR   A 1 255 ? 134.600 129.836 125.052 1.00 32.42  ? 117 THR   R O   1 
ATOM   677  C CB  . THR   A 1 255 ? 133.163 129.264 122.110 1.00 27.18  ? 117 THR   R CB  1 
ATOM   678  O OG1 . THR   A 1 255 ? 131.875 129.533 121.542 1.00 27.13  ? 117 THR   R OG1 1 
ATOM   679  C CG2 . THR   A 1 255 ? 133.085 128.018 122.962 1.00 30.58  ? 117 THR   R CG2 1 
ATOM   680  N N   . VAL   A 1 256 ? 135.987 129.999 123.275 1.00 20.53  ? 118 VAL   R N   1 
ATOM   681  C CA  . VAL   A 1 256 ? 137.155 129.605 124.057 1.00 17.57  ? 118 VAL   R CA  1 
ATOM   682  C C   . VAL   A 1 256 ? 137.378 130.584 125.200 1.00 21.66  ? 118 VAL   R C   1 
ATOM   683  O O   . VAL   A 1 256 ? 137.580 130.182 126.353 1.00 27.63  ? 118 VAL   R O   1 
ATOM   684  C CB  . VAL   A 1 256 ? 138.399 129.501 123.156 1.00 21.57  ? 118 VAL   R CB  1 
ATOM   685  C CG1 . VAL   A 1 256 ? 139.655 129.428 124.000 1.00 25.17  ? 118 VAL   R CG1 1 
ATOM   686  C CG2 . VAL   A 1 256 ? 138.298 128.295 122.243 1.00 21.51  ? 118 VAL   R CG2 1 
ATOM   687  N N   . ASN   A 1 257 ? 137.331 131.886 124.901 1.00 21.11  ? 119 ASN   R N   1 
ATOM   688  C CA  . ASN   A 1 257 ? 137.501 132.884 125.952 1.00 21.80  ? 119 ASN   R CA  1 
ATOM   689  C C   . ASN   A 1 257 ? 136.416 132.755 127.009 1.00 28.59  ? 119 ASN   R C   1 
ATOM   690  O O   . ASN   A 1 257 ? 136.695 132.798 128.215 1.00 36.25  ? 119 ASN   R O   1 
ATOM   691  C CB  . ASN   A 1 257 ? 137.472 134.290 125.364 1.00 12.96  ? 119 ASN   R CB  1 
ATOM   692  C CG  . ASN   A 1 257 ? 137.651 135.352 126.421 1.00 18.05  ? 119 ASN   R CG  1 
ATOM   693  O OD1 . ASN   A 1 257 ? 138.381 135.157 127.389 1.00 34.46  ? 119 ASN   R OD1 1 
ATOM   694  N ND2 . ASN   A 1 257 ? 136.932 136.455 126.281 1.00 24.17  ? 119 ASN   R ND2 1 
ATOM   695  N N   . LEU   A 1 258 ? 135.167 132.596 126.569 1.00 20.92  ? 120 LEU   R N   1 
ATOM   696  C CA  . LEU   A 1 258 ? 134.043 132.624 127.493 1.00 18.57  ? 120 LEU   R CA  1 
ATOM   697  C C   . LEU   A 1 258 ? 134.129 131.490 128.501 1.00 33.58  ? 120 LEU   R C   1 
ATOM   698  O O   . LEU   A 1 258 ? 133.806 131.674 129.680 1.00 41.49  ? 120 LEU   R O   1 
ATOM   699  C CB  . LEU   A 1 258 ? 132.735 132.577 126.701 1.00 18.08  ? 120 LEU   R CB  1 
ATOM   700  C CG  . LEU   A 1 258 ? 131.390 132.239 127.339 1.00 27.00  ? 120 LEU   R CG  1 
ATOM   701  C CD1 . LEU   A 1 258 ? 130.309 132.850 126.485 1.00 33.42  ? 120 LEU   R CD1 1 
ATOM   702  C CD2 . LEU   A 1 258 ? 131.168 130.749 127.426 1.00 22.44  ? 120 LEU   R CD2 1 
ATOM   703  N N   . TYR   A 1 259 ? 134.554 130.306 128.063 1.00 30.87  ? 121 TYR   R N   1 
ATOM   704  C CA  . TYR   A 1 259 ? 134.704 129.226 129.036 1.00 19.32  ? 121 TYR   R CA  1 
ATOM   705  C C   . TYR   A 1 259 ? 135.986 129.339 129.859 1.00 22.93  ? 121 TYR   R C   1 
ATOM   706  O O   . TYR   A 1 259 ? 135.961 129.125 131.084 1.00 33.62  ? 121 TYR   R O   1 
ATOM   707  C CB  . TYR   A 1 259 ? 134.640 127.873 128.328 1.00 25.09  ? 121 TYR   R CB  1 
ATOM   708  C CG  . TYR   A 1 259 ? 133.252 127.539 127.843 1.00 32.13  ? 121 TYR   R CG  1 
ATOM   709  C CD1 . TYR   A 1 259 ? 132.158 127.666 128.685 1.00 35.55  ? 121 TYR   R CD1 1 
ATOM   710  C CD2 . TYR   A 1 259 ? 133.029 127.125 126.539 1.00 35.05  ? 121 TYR   R CD2 1 
ATOM   711  C CE1 . TYR   A 1 259 ? 130.883 127.372 128.249 1.00 34.87  ? 121 TYR   R CE1 1 
ATOM   712  C CE2 . TYR   A 1 259 ? 131.756 126.831 126.093 1.00 35.61  ? 121 TYR   R CE2 1 
ATOM   713  C CZ  . TYR   A 1 259 ? 130.688 126.957 126.952 1.00 39.31  ? 121 TYR   R CZ  1 
ATOM   714  O OH  . TYR   A 1 259 ? 129.418 126.665 126.513 1.00 41.49  ? 121 TYR   R OH  1 
ATOM   715  N N   . SER   A 1 260 ? 137.106 129.687 129.217 1.00 18.94  ? 122 SER   R N   1 
ATOM   716  C CA  . SER   A 1 260 ? 138.385 129.687 129.915 1.00 14.05  ? 122 SER   R CA  1 
ATOM   717  C C   . SER   A 1 260 ? 138.416 130.726 131.027 1.00 28.73  ? 122 SER   R C   1 
ATOM   718  O O   . SER   A 1 260 ? 138.999 130.483 132.086 1.00 39.86  ? 122 SER   R O   1 
ATOM   719  C CB  . SER   A 1 260 ? 139.522 129.933 128.929 1.00 23.89  ? 122 SER   R CB  1 
ATOM   720  O OG  . SER   A 1 260 ? 139.760 131.319 128.780 1.00 38.42  ? 122 SER   R OG  1 
ATOM   721  N N   . SER   A 1 261 ? 137.797 131.890 130.811 1.00 23.95  ? 123 SER   R N   1 
ATOM   722  C CA  . SER   A 1 261 ? 137.846 132.943 131.822 1.00 19.30  ? 123 SER   R CA  1 
ATOM   723  C C   . SER   A 1 261 ? 137.183 132.500 133.122 1.00 22.99  ? 123 SER   R C   1 
ATOM   724  O O   . SER   A 1 261 ? 137.783 132.574 134.206 1.00 35.32  ? 123 SER   R O   1 
ATOM   725  C CB  . SER   A 1 261 ? 137.176 134.204 131.283 1.00 24.95  ? 123 SER   R CB  1 
ATOM   726  O OG  . SER   A 1 261 ? 135.878 133.914 130.798 1.00 35.97  ? 123 SER   R OG  1 
ATOM   727  N N   . VAL   A 1 262 ? 135.942 132.020 133.031 1.00 17.29  ? 124 VAL   R N   1 
ATOM   728  C CA  . VAL   A 1 262 ? 135.215 131.645 134.235 1.00 17.86  ? 124 VAL   R CA  1 
ATOM   729  C C   . VAL   A 1 262 ? 135.850 130.425 134.890 1.00 25.75  ? 124 VAL   R C   1 
ATOM   730  O O   . VAL   A 1 262 ? 135.905 130.333 136.125 1.00 32.65  ? 124 VAL   R O   1 
ATOM   731  C CB  . VAL   A 1 262 ? 133.726 131.425 133.910 1.00 14.48  ? 124 VAL   R CB  1 
ATOM   732  C CG1 . VAL   A 1 262 ? 133.559 130.471 132.746 1.00 28.29  ? 124 VAL   R CG1 1 
ATOM   733  C CG2 . VAL   A 1 262 ? 132.972 130.947 135.130 1.00 19.98  ? 124 VAL   R CG2 1 
ATOM   734  N N   . TRP   A 1 263 ? 136.369 129.478 134.102 1.00 24.83  ? 125 TRP   R N   1 
ATOM   735  C CA  . TRP   A 1 263 ? 136.972 128.326 134.760 1.00 14.36  ? 125 TRP   R CA  1 
ATOM   736  C C   . TRP   A 1 263 ? 138.341 128.640 135.353 1.00 23.49  ? 125 TRP   R C   1 
ATOM   737  O O   . TRP   A 1 263 ? 138.740 128.006 136.335 1.00 40.17  ? 125 TRP   R O   1 
ATOM   738  C CB  . TRP   A 1 263 ? 137.024 127.145 133.798 1.00 18.79  ? 125 TRP   R CB  1 
ATOM   739  C CG  . TRP   A 1 263 ? 135.719 126.419 133.801 1.00 22.19  ? 125 TRP   R CG  1 
ATOM   740  C CD1 . TRP   A 1 263 ? 134.758 126.457 132.839 1.00 27.19  ? 125 TRP   R CD1 1 
ATOM   741  C CD2 . TRP   A 1 263 ? 135.217 125.569 134.837 1.00 31.10  ? 125 TRP   R CD2 1 
ATOM   742  N NE1 . TRP   A 1 263 ? 133.691 125.674 133.205 1.00 28.34  ? 125 TRP   R NE1 1 
ATOM   743  C CE2 . TRP   A 1 263 ? 133.951 125.116 134.428 1.00 31.06  ? 125 TRP   R CE2 1 
ATOM   744  C CE3 . TRP   A 1 263 ? 135.721 125.139 136.068 1.00 30.90  ? 125 TRP   R CE3 1 
ATOM   745  C CZ2 . TRP   A 1 263 ? 133.181 124.256 135.203 1.00 29.71  ? 125 TRP   R CZ2 1 
ATOM   746  C CZ3 . TRP   A 1 263 ? 134.955 124.288 136.836 1.00 25.77  ? 125 TRP   R CZ3 1 
ATOM   747  C CH2 . TRP   A 1 263 ? 133.699 123.855 136.401 1.00 22.41  ? 125 TRP   R CH2 1 
ATOM   748  N N   . ILE   A 1 264 ? 139.054 129.635 134.823 1.00 16.95  ? 126 ILE   R N   1 
ATOM   749  C CA  . ILE   A 1 264 ? 140.263 130.102 135.493 1.00 8.94   ? 126 ILE   R CA  1 
ATOM   750  C C   . ILE   A 1 264 ? 139.905 130.782 136.807 1.00 24.90  ? 126 ILE   R C   1 
ATOM   751  O O   . ILE   A 1 264 ? 140.623 130.652 137.806 1.00 38.72  ? 126 ILE   R O   1 
ATOM   752  C CB  . ILE   A 1 264 ? 141.066 131.031 134.566 1.00 14.85  ? 126 ILE   R CB  1 
ATOM   753  C CG1 . ILE   A 1 264 ? 141.836 130.210 133.534 1.00 30.67  ? 126 ILE   R CG1 1 
ATOM   754  C CG2 . ILE   A 1 264 ? 142.027 131.893 135.362 1.00 16.83  ? 126 ILE   R CG2 1 
ATOM   755  C CD1 . ILE   A 1 264 ? 142.303 131.013 132.347 1.00 23.21  ? 126 ILE   R CD1 1 
ATOM   756  N N   . LEU   A 1 265 ? 138.788 131.511 136.834 1.00 29.34  ? 127 LEU   R N   1 
ATOM   757  C CA  . LEU   A 1 265 ? 138.318 132.065 138.102 1.00 22.69  ? 127 LEU   R CA  1 
ATOM   758  C C   . LEU   A 1 265 ? 138.013 130.958 139.108 1.00 22.40  ? 127 LEU   R C   1 
ATOM   759  O O   . LEU   A 1 265 ? 138.352 131.070 140.295 1.00 27.62  ? 127 LEU   R O   1 
ATOM   760  C CB  . LEU   A 1 265 ? 137.084 132.935 137.869 1.00 24.30  ? 127 LEU   R CB  1 
ATOM   761  C CG  . LEU   A 1 265 ? 137.341 134.354 137.365 1.00 19.96  ? 127 LEU   R CG  1 
ATOM   762  C CD1 . LEU   A 1 265 ? 136.074 135.177 137.445 1.00 29.91  ? 127 LEU   R CD1 1 
ATOM   763  C CD2 . LEU   A 1 265 ? 138.452 135.006 138.157 1.00 22.85  ? 127 LEU   R CD2 1 
ATOM   764  N N   . ALA   A 1 266 ? 137.374 129.879 138.650 1.00 22.58  ? 128 ALA   R N   1 
ATOM   765  C CA  . ALA   A 1 266 ? 137.097 128.748 139.535 1.00 21.41  ? 128 ALA   R CA  1 
ATOM   766  C C   . ALA   A 1 266 ? 138.384 128.109 140.047 1.00 14.59  ? 128 ALA   R C   1 
ATOM   767  O O   . ALA   A 1 266 ? 138.469 127.716 141.216 1.00 30.26  ? 128 ALA   R O   1 
ATOM   768  C CB  . ALA   A 1 266 ? 136.237 127.712 138.815 1.00 23.09  ? 128 ALA   R CB  1 
ATOM   769  N N   . PHE   A 1 267 ? 139.392 127.979 139.181 1.00 20.24  ? 129 PHE   R N   1 
ATOM   770  C CA  . PHE   A 1 267 ? 140.681 127.451 139.622 1.00 18.19  ? 129 PHE   R CA  1 
ATOM   771  C C   . PHE   A 1 267 ? 141.349 128.361 140.646 1.00 24.17  ? 129 PHE   R C   1 
ATOM   772  O O   . PHE   A 1 267 ? 141.965 127.867 141.595 1.00 36.11  ? 129 PHE   R O   1 
ATOM   773  C CB  . PHE   A 1 267 ? 141.607 127.230 138.427 1.00 26.64  ? 129 PHE   R CB  1 
ATOM   774  C CG  . PHE   A 1 267 ? 141.577 125.828 137.893 1.00 27.97  ? 129 PHE   R CG  1 
ATOM   775  C CD1 . PHE   A 1 267 ? 142.711 125.039 137.925 1.00 24.67  ? 129 PHE   R CD1 1 
ATOM   776  C CD2 . PHE   A 1 267 ? 140.413 125.300 137.366 1.00 26.46  ? 129 PHE   R CD2 1 
ATOM   777  C CE1 . PHE   A 1 267 ? 142.685 123.750 137.442 1.00 21.59  ? 129 PHE   R CE1 1 
ATOM   778  C CE2 . PHE   A 1 267 ? 140.383 124.011 136.878 1.00 32.21  ? 129 PHE   R CE2 1 
ATOM   779  C CZ  . PHE   A 1 267 ? 141.520 123.237 136.916 1.00 32.01  ? 129 PHE   R CZ  1 
ATOM   780  N N   . ILE   A 1 268 ? 141.251 129.681 140.470 1.00 28.04  ? 130 ILE   R N   1 
ATOM   781  C CA  . ILE   A 1 268 ? 141.780 130.606 141.473 1.00 25.71  ? 130 ILE   R CA  1 
ATOM   782  C C   . ILE   A 1 268 ? 141.078 130.397 142.807 1.00 30.33  ? 130 ILE   R C   1 
ATOM   783  O O   . ILE   A 1 268 ? 141.716 130.375 143.869 1.00 31.15  ? 130 ILE   R O   1 
ATOM   784  C CB  . ILE   A 1 268 ? 141.634 132.064 141.001 1.00 26.81  ? 130 ILE   R CB  1 
ATOM   785  C CG1 . ILE   A 1 268 ? 142.550 132.347 139.818 1.00 28.91  ? 130 ILE   R CG1 1 
ATOM   786  C CG2 . ILE   A 1 268 ? 141.951 133.022 142.134 1.00 24.11  ? 130 ILE   R CG2 1 
ATOM   787  C CD1 . ILE   A 1 268 ? 142.543 133.792 139.380 1.00 31.12  ? 130 ILE   R CD1 1 
ATOM   788  N N   . SER   A 1 269 ? 139.752 130.259 142.775 1.00 29.12  ? 131 SER   R N   1 
ATOM   789  C CA  . SER   A 1 269 ? 138.998 130.041 144.004 1.00 25.85  ? 131 SER   R CA  1 
ATOM   790  C C   . SER   A 1 269 ? 139.431 128.757 144.701 1.00 29.24  ? 131 SER   R C   1 
ATOM   791  O O   . SER   A 1 269 ? 139.633 128.737 145.923 1.00 31.85  ? 131 SER   R O   1 
ATOM   792  C CB  . SER   A 1 269 ? 137.505 130.003 143.690 1.00 27.90  ? 131 SER   R CB  1 
ATOM   793  O OG  . SER   A 1 269 ? 136.771 129.445 144.761 1.00 39.33  ? 131 SER   R OG  1 
ATOM   794  N N   . LEU   A 1 270 ? 139.580 127.674 143.936 1.00 29.30  ? 132 LEU   R N   1 
ATOM   795  C CA  . LEU   A 1 270 ? 140.008 126.406 144.518 1.00 21.29  ? 132 LEU   R CA  1 
ATOM   796  C C   . LEU   A 1 270 ? 141.415 126.510 145.093 1.00 28.37  ? 132 LEU   R C   1 
ATOM   797  O O   . LEU   A 1 270 ? 141.702 125.954 146.161 1.00 42.72  ? 132 LEU   R O   1 
ATOM   798  C CB  . LEU   A 1 270 ? 139.931 125.301 143.466 1.00 16.75  ? 132 LEU   R CB  1 
ATOM   799  C CG  . LEU   A 1 270 ? 140.215 123.877 143.931 1.00 32.89  ? 132 LEU   R CG  1 
ATOM   800  C CD1 . LEU   A 1 270 ? 139.373 123.539 145.143 1.00 33.31  ? 132 LEU   R CD1 1 
ATOM   801  C CD2 . LEU   A 1 270 ? 139.942 122.904 142.799 1.00 32.09  ? 132 LEU   R CD2 1 
ATOM   802  N N   . ASP   A 1 271 ? 142.308 127.215 144.397 1.00 26.79  ? 133 ASP   R N   1 
ATOM   803  C CA  . ASP   A 1 271 ? 143.662 127.405 144.904 1.00 23.38  ? 133 ASP   R CA  1 
ATOM   804  C C   . ASP   A 1 271 ? 143.654 128.171 146.219 1.00 27.56  ? 133 ASP   R C   1 
ATOM   805  O O   . ASP   A 1 271 ? 144.389 127.827 147.150 1.00 32.74  ? 133 ASP   R O   1 
ATOM   806  C CB  . ASP   A 1 271 ? 144.509 128.137 143.865 1.00 40.20  ? 133 ASP   R CB  1 
ATOM   807  C CG  . ASP   A 1 271 ? 145.893 128.474 144.374 1.00 42.74  ? 133 ASP   R CG  1 
ATOM   808  O OD1 . ASP   A 1 271 ? 146.044 129.508 145.055 1.00 36.70  ? 133 ASP   R OD1 1 
ATOM   809  O OD2 . ASP   A 1 271 ? 146.833 127.707 144.087 1.00 49.99  ? 133 ASP   R OD2 1 
ATOM   810  N N   . ARG   A 1 272 ? 142.834 129.220 146.310 1.00 39.78  ? 134 ARG   R N   1 
ATOM   811  C CA  . ARG   A 1 272 ? 142.749 129.979 147.553 1.00 37.60  ? 134 ARG   R CA  1 
ATOM   812  C C   . ARG   A 1 272 ? 142.209 129.118 148.687 1.00 34.21  ? 134 ARG   R C   1 
ATOM   813  O O   . ARG   A 1 272 ? 142.709 129.182 149.818 1.00 33.13  ? 134 ARG   R O   1 
ATOM   814  C CB  . ARG   A 1 272 ? 141.880 131.220 147.354 1.00 29.24  ? 134 ARG   R CB  1 
ATOM   815  C CG  . ARG   A 1 272 ? 142.649 132.439 146.885 1.00 24.56  ? 134 ARG   R CG  1 
ATOM   816  C CD  . ARG   A 1 272 ? 143.741 132.798 147.870 1.00 30.41  ? 134 ARG   R CD  1 
ATOM   817  N NE  . ARG   A 1 272 ? 145.060 132.399 147.399 1.00 33.60  ? 134 ARG   R NE  1 
ATOM   818  C CZ  . ARG   A 1 272 ? 146.144 132.355 148.162 1.00 33.24  ? 134 ARG   R CZ  1 
ATOM   819  N NH1 . ARG   A 1 272 ? 146.099 132.672 149.444 1.00 36.22  ? 134 ARG   R NH1 1 
ATOM   820  N NH2 . ARG   A 1 272 ? 147.300 131.980 147.624 1.00 35.16  ? 134 ARG   R NH2 1 
ATOM   821  N N   . TYR   A 1 273 ? 141.191 128.302 148.401 1.00 35.68  ? 135 TYR   R N   1 
ATOM   822  C CA  . TYR   A 1 273 ? 140.655 127.406 149.422 1.00 32.50  ? 135 TYR   R CA  1 
ATOM   823  C C   . TYR   A 1 273 ? 141.724 126.445 149.923 1.00 30.19  ? 135 TYR   R C   1 
ATOM   824  O O   . TYR   A 1 273 ? 141.873 126.238 151.132 1.00 42.65  ? 135 TYR   R O   1 
ATOM   825  C CB  . TYR   A 1 273 ? 139.457 126.633 148.871 1.00 30.88  ? 135 TYR   R CB  1 
ATOM   826  C CG  . TYR   A 1 273 ? 139.182 125.339 149.601 1.00 25.41  ? 135 TYR   R CG  1 
ATOM   827  C CD1 . TYR   A 1 273 ? 138.437 125.326 150.767 1.00 36.82  ? 135 TYR   R CD1 1 
ATOM   828  C CD2 . TYR   A 1 273 ? 139.658 124.130 149.118 1.00 30.81  ? 135 TYR   R CD2 1 
ATOM   829  C CE1 . TYR   A 1 273 ? 138.181 124.148 151.437 1.00 37.83  ? 135 TYR   R CE1 1 
ATOM   830  C CE2 . TYR   A 1 273 ? 139.408 122.947 149.783 1.00 39.80  ? 135 TYR   R CE2 1 
ATOM   831  C CZ  . TYR   A 1 273 ? 138.669 122.962 150.941 1.00 36.83  ? 135 TYR   R CZ  1 
ATOM   832  O OH  . TYR   A 1 273 ? 138.416 121.785 151.606 1.00 36.49  ? 135 TYR   R OH  1 
ATOM   833  N N   . LEU   A 1 274 ? 142.483 125.850 149.001 1.00 35.56  ? 136 LEU   R N   1 
ATOM   834  C CA  . LEU   A 1 274 ? 143.534 124.923 149.407 1.00 33.18  ? 136 LEU   R CA  1 
ATOM   835  C C   . LEU   A 1 274 ? 144.614 125.631 150.212 1.00 33.45  ? 136 LEU   R C   1 
ATOM   836  O O   . LEU   A 1 274 ? 145.142 125.074 151.179 1.00 35.40  ? 136 LEU   R O   1 
ATOM   837  C CB  . LEU   A 1 274 ? 144.144 124.243 148.182 1.00 30.73  ? 136 LEU   R CB  1 
ATOM   838  C CG  . LEU   A 1 274 ? 143.506 122.930 147.735 1.00 26.10  ? 136 LEU   R CG  1 
ATOM   839  C CD1 . LEU   A 1 274 ? 144.004 122.553 146.354 1.00 35.64  ? 136 LEU   R CD1 1 
ATOM   840  C CD2 . LEU   A 1 274 ? 143.801 121.826 148.732 1.00 31.41  ? 136 LEU   R CD2 1 
ATOM   841  N N   . ALA   A 1 275 ? 144.959 126.860 149.827 1.00 33.40  ? 137 ALA   R N   1 
ATOM   842  C CA  . ALA   A 1 275 ? 146.036 127.569 150.510 1.00 29.96  ? 137 ALA   R CA  1 
ATOM   843  C C   . ALA   A 1 275 ? 145.623 128.006 151.908 1.00 32.32  ? 137 ALA   R C   1 
ATOM   844  O O   . ALA   A 1 275 ? 146.458 128.059 152.816 1.00 38.63  ? 137 ALA   R O   1 
ATOM   845  C CB  . ALA   A 1 275 ? 146.479 128.775 149.683 1.00 38.98  ? 137 ALA   R CB  1 
ATOM   846  N N   . ILE   A 1 276 ? 144.349 128.332 152.103 1.00 37.15  ? 138 ILE   R N   1 
ATOM   847  C CA  . ILE   A 1 276 ? 143.902 128.841 153.398 1.00 35.17  ? 138 ILE   R CA  1 
ATOM   848  C C   . ILE   A 1 276 ? 143.513 127.711 154.343 1.00 32.35  ? 138 ILE   R C   1 
ATOM   849  O O   . ILE   A 1 276 ? 143.967 127.667 155.489 1.00 32.78  ? 138 ILE   R O   1 
ATOM   850  C CB  . ILE   A 1 276 ? 142.745 129.844 153.203 1.00 30.09  ? 138 ILE   R CB  1 
ATOM   851  C CG1 . ILE   A 1 276 ? 143.302 131.241 152.920 1.00 28.85  ? 138 ILE   R CG1 1 
ATOM   852  C CG2 . ILE   A 1 276 ? 141.848 129.876 154.428 1.00 32.26  ? 138 ILE   R CG2 1 
ATOM   853  C CD1 . ILE   A 1 276 ? 142.266 132.336 152.964 1.00 28.88  ? 138 ILE   R CD1 1 
ATOM   854  N N   . VAL   A 1 277 ? 142.672 126.777 153.891 1.00 36.72  ? 139 VAL   R N   1 
ATOM   855  C CA  . VAL   A 1 277 ? 142.182 125.732 154.787 1.00 31.71  ? 139 VAL   R CA  1 
ATOM   856  C C   . VAL   A 1 277 ? 143.305 124.775 155.171 1.00 32.10  ? 139 VAL   R C   1 
ATOM   857  O O   . VAL   A 1 277 ? 143.480 124.443 156.348 1.00 39.69  ? 139 VAL   R O   1 
ATOM   858  C CB  . VAL   A 1 277 ? 140.999 124.988 154.145 1.00 30.93  ? 139 VAL   R CB  1 
ATOM   859  C CG1 . VAL   A 1 277 ? 140.623 123.783 154.980 1.00 29.79  ? 139 VAL   R CG1 1 
ATOM   860  C CG2 . VAL   A 1 277 ? 139.821 125.922 154.004 1.00 32.46  ? 139 VAL   R CG2 1 
ATOM   861  N N   . HIS   A 1 278 ? 144.079 124.319 154.192 1.00 32.23  ? 140 HIS   R N   1 
ATOM   862  C CA  . HIS   A 1 278 ? 145.202 123.410 154.417 1.00 33.73  ? 140 HIS   R CA  1 
ATOM   863  C C   . HIS   A 1 278 ? 146.476 124.187 154.101 1.00 41.14  ? 140 HIS   R C   1 
ATOM   864  O O   . HIS   A 1 278 ? 146.995 124.129 152.987 1.00 51.36  ? 140 HIS   R O   1 
ATOM   865  C CB  . HIS   A 1 278 ? 145.078 122.158 153.554 1.00 39.56  ? 140 HIS   R CB  1 
ATOM   866  C CG  . HIS   A 1 278 ? 143.685 121.611 153.469 1.00 49.57  ? 140 HIS   R CG  1 
ATOM   867  N ND1 . HIS   A 1 278 ? 143.228 120.603 154.290 1.00 49.36  ? 140 HIS   R ND1 1 
ATOM   868  C CD2 . HIS   A 1 278 ? 142.650 121.929 152.655 1.00 47.35  ? 140 HIS   R CD2 1 
ATOM   869  C CE1 . HIS   A 1 278 ? 141.972 120.325 153.988 1.00 45.96  ? 140 HIS   R CE1 1 
ATOM   870  N NE2 . HIS   A 1 278 ? 141.598 121.116 152.999 1.00 42.03  ? 140 HIS   R NE2 1 
ATOM   871  N N   . ALA   A 1 279 ? 146.990 124.907 155.099 1.00 47.52  ? 141 ALA   R N   1 
ATOM   872  C CA  . ALA   A 1 279 ? 148.039 125.894 154.869 1.00 52.20  ? 141 ALA   R CA  1 
ATOM   873  C C   . ALA   A 1 279 ? 149.451 125.321 154.895 1.00 52.12  ? 141 ALA   R C   1 
ATOM   874  O O   . ALA   A 1 279 ? 150.393 126.043 154.552 1.00 49.97  ? 141 ALA   R O   1 
ATOM   875  C CB  . ALA   A 1 279 ? 147.935 127.015 155.903 1.00 45.19  ? 141 ALA   R CB  1 
ATOM   876  N N   . THR   A 1 280 ? 149.633 124.060 155.288 1.00 55.34  ? 142 THR   R N   1 
ATOM   877  C CA  . THR   A 1 280 ? 150.967 123.491 155.419 1.00 51.62  ? 142 THR   R CA  1 
ATOM   878  C C   . THR   A 1 280 ? 151.201 122.232 154.599 1.00 54.11  ? 142 THR   R C   1 
ATOM   879  O O   . THR   A 1 280 ? 152.362 121.895 154.345 1.00 58.09  ? 142 THR   R O   1 
ATOM   880  C CB  . THR   A 1 280 ? 151.273 123.169 156.890 1.00 54.04  ? 142 THR   R CB  1 
ATOM   881  O OG1 . THR   A 1 280 ? 150.255 122.308 157.415 1.00 53.09  ? 142 THR   R OG1 1 
ATOM   882  C CG2 . THR   A 1 280 ? 151.321 124.445 157.713 1.00 54.23  ? 142 THR   R CG2 1 
ATOM   883  N N   . ASN   A 1 281 ? 150.149 121.530 154.178 1.00 58.64  ? 143 ASN   R N   1 
ATOM   884  C CA  . ASN   A 1 281 ? 150.294 120.282 153.440 1.00 57.02  ? 143 ASN   R CA  1 
ATOM   885  C C   . ASN   A 1 281 ? 149.773 120.375 152.012 1.00 53.18  ? 143 ASN   R C   1 
ATOM   886  O O   . ASN   A 1 281 ? 149.617 119.341 151.354 1.00 57.14  ? 143 ASN   R O   1 
ATOM   887  C CB  . ASN   A 1 281 ? 149.579 119.144 154.176 1.00 58.20  ? 143 ASN   R CB  1 
ATOM   888  C CG  . ASN   A 1 281 ? 148.176 119.522 154.609 1.00 58.98  ? 143 ASN   R CG  1 
ATOM   889  O OD1 . ASN   A 1 281 ? 147.775 120.682 154.516 1.00 57.82  ? 143 ASN   R OD1 1 
ATOM   890  N ND2 . ASN   A 1 281 ? 147.419 118.540 155.083 1.00 56.89  ? 143 ASN   R ND2 1 
ATOM   891  N N   . SER   A 1 282 ? 149.503 121.579 151.513 1.00 45.46  ? 144 SER   R N   1 
ATOM   892  C CA  . SER   A 1 282 ? 148.900 121.756 150.200 1.00 49.72  ? 144 SER   R CA  1 
ATOM   893  C C   . SER   A 1 282 ? 149.876 122.287 149.160 1.00 53.96  ? 144 SER   R C   1 
ATOM   894  O O   . SER   A 1 282 ? 149.451 122.636 148.056 1.00 60.03  ? 144 SER   R O   1 
ATOM   895  C CB  . SER   A 1 282 ? 147.693 122.688 150.295 1.00 51.32  ? 144 SER   R CB  1 
ATOM   896  O OG  . SER   A 1 282 ? 148.083 123.965 150.769 1.00 50.24  ? 144 SER   R OG  1 
ATOM   897  N N   . GLN   A 1 283 ? 151.169 122.357 149.479 1.00 55.06  ? 145 GLN   R N   1 
ATOM   898  C CA  . GLN   A 1 283 ? 152.137 122.868 148.513 1.00 51.78  ? 145 GLN   R CA  1 
ATOM   899  C C   . GLN   A 1 283 ? 152.163 122.012 147.253 1.00 54.80  ? 145 GLN   R C   1 
ATOM   900  O O   . GLN   A 1 283 ? 152.054 122.528 146.135 1.00 59.89  ? 145 GLN   R O   1 
ATOM   901  C CB  . GLN   A 1 283 ? 153.528 122.932 149.142 1.00 50.34  ? 145 GLN   R CB  1 
ATOM   902  C CG  . GLN   A 1 283 ? 153.914 124.305 149.655 1.00 56.78  ? 145 GLN   R CG  1 
ATOM   903  C CD  . GLN   A 1 283 ? 153.887 125.359 148.568 1.00 59.76  ? 145 GLN   R CD  1 
ATOM   904  O OE1 . GLN   A 1 283 ? 154.194 125.082 147.409 1.00 61.51  ? 145 GLN   R OE1 1 
ATOM   905  N NE2 . GLN   A 1 283 ? 153.525 126.580 148.939 1.00 54.59  ? 145 GLN   R NE2 1 
ATOM   906  N N   . ARG   A 1 284 ? 152.318 120.694 147.417 1.00 56.25  ? 146 ARG   R N   1 
ATOM   907  C CA  . ARG   A 1 284 ? 152.362 119.815 146.249 1.00 58.61  ? 146 ARG   R CA  1 
ATOM   908  C C   . ARG   A 1 284 ? 151.041 119.791 145.489 1.00 58.63  ? 146 ARG   R C   1 
ATOM   909  O O   . ARG   A 1 284 ? 151.069 119.884 144.249 1.00 62.18  ? 146 ARG   R O   1 
ATOM   910  C CB  . ARG   A 1 284 ? 152.810 118.412 146.671 1.00 58.55  ? 146 ARG   R CB  1 
ATOM   911  C CG  . ARG   A 1 284 ? 153.422 117.596 145.546 1.00 63.65  ? 146 ARG   R CG  1 
ATOM   912  C CD  . ARG   A 1 284 ? 154.912 117.871 145.417 1.00 65.78  ? 146 ARG   R CD  1 
ATOM   913  N NE  . ARG   A 1 284 ? 155.554 116.985 144.453 1.00 69.92  ? 146 ARG   R NE  1 
ATOM   914  C CZ  . ARG   A 1 284 ? 156.830 117.063 144.099 1.00 67.80  ? 146 ARG   R CZ  1 
ATOM   915  N NH1 . ARG   A 1 284 ? 157.635 117.979 144.612 1.00 65.76  ? 146 ARG   R NH1 1 
ATOM   916  N NH2 . ARG   A 1 284 ? 157.309 116.202 143.206 1.00 65.41  ? 146 ARG   R NH2 1 
ATOM   917  N N   . PRO   A 1 285 ? 149.872 119.635 146.128 1.00 51.66  ? 147 PRO   R N   1 
ATOM   918  C CA  . PRO   A 1 285 ? 148.624 119.718 145.352 1.00 47.90  ? 147 PRO   R CA  1 
ATOM   919  C C   . PRO   A 1 285 ? 148.441 121.044 144.640 1.00 50.23  ? 147 PRO   R C   1 
ATOM   920  O O   . PRO   A 1 285 ? 147.956 121.060 143.504 1.00 59.35  ? 147 PRO   R O   1 
ATOM   921  C CB  . PRO   A 1 285 ? 147.537 119.482 146.409 1.00 45.29  ? 147 PRO   R CB  1 
ATOM   922  C CG  . PRO   A 1 285 ? 148.204 118.681 147.448 1.00 52.23  ? 147 PRO   R CG  1 
ATOM   923  C CD  . PRO   A 1 285 ? 149.609 119.205 147.514 1.00 56.28  ? 147 PRO   R CD  1 
ATOM   924  N N   . ARG   A 1 286 ? 148.825 122.161 145.263 1.00 42.37  ? 148 ARG   R N   1 
ATOM   925  C CA  . ARG   A 1 286 ? 148.687 123.454 144.598 1.00 45.80  ? 148 ARG   R CA  1 
ATOM   926  C C   . ARG   A 1 286 ? 149.619 123.563 143.400 1.00 47.73  ? 148 ARG   R C   1 
ATOM   927  O O   . ARG   A 1 286 ? 149.220 124.057 142.338 1.00 56.13  ? 148 ARG   R O   1 
ATOM   928  C CB  . ARG   A 1 286 ? 148.949 124.586 145.589 1.00 46.69  ? 148 ARG   R CB  1 
ATOM   929  C CG  . ARG   A 1 286 ? 147.763 124.919 146.480 1.00 45.08  ? 148 ARG   R CG  1 
ATOM   930  C CD  . ARG   A 1 286 ? 148.169 125.873 147.590 1.00 45.76  ? 148 ARG   R CD  1 
ATOM   931  N NE  . ARG   A 1 286 ? 148.273 127.246 147.117 1.00 50.74  ? 148 ARG   R NE  1 
ATOM   932  C CZ  . ARG   A 1 286 ? 149.385 127.967 147.156 1.00 50.01  ? 148 ARG   R CZ  1 
ATOM   933  N NH1 . ARG   A 1 286 ? 150.512 127.471 147.636 1.00 45.05  ? 148 ARG   R NH1 1 
ATOM   934  N NH2 . ARG   A 1 286 ? 149.365 129.215 146.699 1.00 47.62  ? 148 ARG   R NH2 1 
ATOM   935  N N   . LYS   A 1 287 ? 150.862 123.102 143.547 1.00 42.55  ? 149 LYS   R N   1 
ATOM   936  C CA  . LYS   A 1 287 ? 151.801 123.135 142.431 1.00 40.80  ? 149 LYS   R CA  1 
ATOM   937  C C   . LYS   A 1 287 ? 151.309 122.272 141.276 1.00 45.31  ? 149 LYS   R C   1 
ATOM   938  O O   . LYS   A 1 287 ? 151.351 122.690 140.114 1.00 48.91  ? 149 LYS   R O   1 
ATOM   939  C CB  . LYS   A 1 287 ? 153.180 122.678 142.903 1.00 46.01  ? 149 LYS   R CB  1 
ATOM   940  C CG  . LYS   A 1 287 ? 154.225 122.609 141.810 1.00 49.47  ? 149 LYS   R CG  1 
ATOM   941  C CD  . LYS   A 1 287 ? 154.657 121.174 141.555 1.00 51.90  ? 149 LYS   R CD  1 
ATOM   942  C CE  . LYS   A 1 287 ? 155.948 121.119 140.757 1.00 50.87  ? 149 LYS   R CE  1 
ATOM   943  N NZ  . LYS   A 1 287 ? 156.372 119.717 140.486 1.00 55.25  ? 149 LYS   R NZ  1 
ATOM   944  N N   . LEU   A 1 288 ? 150.818 121.068 141.580 1.00 42.63  ? 150 LEU   R N   1 
ATOM   945  C CA  . LEU   A 1 288 ? 150.306 120.193 140.528 1.00 38.63  ? 150 LEU   R CA  1 
ATOM   946  C C   . LEU   A 1 288 ? 149.076 120.790 139.856 1.00 41.35  ? 150 LEU   R C   1 
ATOM   947  O O   . LEU   A 1 288 ? 148.962 120.767 138.625 1.00 49.30  ? 150 LEU   R O   1 
ATOM   948  C CB  . LEU   A 1 288 ? 149.987 118.814 141.100 1.00 38.15  ? 150 LEU   R CB  1 
ATOM   949  C CG  . LEU   A 1 288 ? 151.073 117.748 140.947 1.00 50.68  ? 150 LEU   R CG  1 
ATOM   950  C CD1 . LEU   A 1 288 ? 151.309 117.446 139.481 1.00 48.20  ? 150 LEU   R CD1 1 
ATOM   951  C CD2 . LEU   A 1 288 ? 152.367 118.178 141.619 1.00 48.58  ? 150 LEU   R CD2 1 
ATOM   952  N N   . LEU   A 1 289 ? 148.156 121.344 140.647 1.00 28.26  ? 151 LEU   R N   1 
ATOM   953  C CA  . LEU   A 1 289 ? 146.942 121.931 140.095 1.00 17.64  ? 151 LEU   R CA  1 
ATOM   954  C C   . LEU   A 1 289 ? 147.258 123.114 139.191 1.00 30.18  ? 151 LEU   R C   1 
ATOM   955  O O   . LEU   A 1 289 ? 146.628 123.286 138.142 1.00 40.36  ? 151 LEU   R O   1 
ATOM   956  C CB  . LEU   A 1 289 ? 146.016 122.351 141.235 1.00 26.10  ? 151 LEU   R CB  1 
ATOM   957  C CG  . LEU   A 1 289 ? 144.603 122.820 140.900 1.00 38.25  ? 151 LEU   R CG  1 
ATOM   958  C CD1 . LEU   A 1 289 ? 143.655 121.638 140.845 1.00 41.40  ? 151 LEU   R CD1 1 
ATOM   959  C CD2 . LEU   A 1 289 ? 144.131 123.834 141.926 1.00 32.27  ? 151 LEU   R CD2 1 
ATOM   960  N N   . ALA   A 1 290 ? 148.224 123.947 139.580 1.00 39.56  ? 152 ALA   R N   1 
ATOM   961  C CA  . ALA   A 1 290 ? 148.567 125.109 138.770 1.00 36.01  ? 152 ALA   R CA  1 
ATOM   962  C C   . ALA   A 1 290 ? 149.494 124.779 137.608 1.00 37.79  ? 152 ALA   R C   1 
ATOM   963  O O   . ALA   A 1 290 ? 149.610 125.590 136.685 1.00 45.45  ? 152 ALA   R O   1 
ATOM   964  C CB  . ALA   A 1 290 ? 149.211 126.189 139.641 1.00 36.11  ? 152 ALA   R CB  1 
ATOM   965  N N   . GLU   A 1 291 ? 150.162 123.626 137.630 1.00 34.60  ? 153 GLU   R N   1 
ATOM   966  C CA  . GLU   A 1 291 ? 151.074 123.278 136.546 1.00 30.44  ? 153 GLU   R CA  1 
ATOM   967  C C   . GLU   A 1 291 ? 150.417 122.390 135.492 1.00 37.95  ? 153 GLU   R C   1 
ATOM   968  O O   . GLU   A 1 291 ? 150.350 122.761 134.317 1.00 50.71  ? 153 GLU   R O   1 
ATOM   969  C CB  . GLU   A 1 291 ? 152.323 122.596 137.113 1.00 41.21  ? 153 GLU   R CB  1 
ATOM   970  C CG  . GLU   A 1 291 ? 153.321 123.557 137.733 1.00 49.53  ? 153 GLU   R CG  1 
ATOM   971  C CD  . GLU   A 1 291 ? 154.679 122.921 137.961 1.00 52.19  ? 153 GLU   R CD  1 
ATOM   972  O OE1 . GLU   A 1 291 ? 154.830 121.717 137.665 1.00 48.61  ? 153 GLU   R OE1 1 
ATOM   973  O OE2 . GLU   A 1 291 ? 155.594 123.625 138.437 1.00 48.95  ? 153 GLU   R OE2 1 
ATOM   974  N N   . LYS   A 1 292 ? 149.931 121.216 135.892 1.00 40.99  ? 154 LYS   R N   1 
ATOM   975  C CA  . LYS   A 1 292 ? 149.496 120.215 134.924 1.00 38.98  ? 154 LYS   R CA  1 
ATOM   976  C C   . LYS   A 1 292 ? 147.985 120.128 134.779 1.00 36.20  ? 154 LYS   R C   1 
ATOM   977  O O   . LYS   A 1 292 ? 147.483 120.067 133.656 1.00 45.45  ? 154 LYS   R O   1 
ATOM   978  C CB  . LYS   A 1 292 ? 150.045 118.838 135.308 1.00 42.29  ? 154 LYS   R CB  1 
ATOM   979  C CG  . LYS   A 1 292 ? 151.527 118.665 135.019 1.00 45.80  ? 154 LYS   R CG  1 
ATOM   980  C CD  . LYS   A 1 292 ? 151.930 117.201 135.011 1.00 48.82  ? 154 LYS   R CD  1 
ATOM   981  C CE  . LYS   A 1 292 ? 152.837 116.870 136.186 1.00 47.26  ? 154 LYS   R CE  1 
ATOM   982  N NZ  . LYS   A 1 292 ? 152.763 115.431 136.562 1.00 47.43  ? 154 LYS   R NZ  1 
ATOM   983  N N   . VAL   A 1 293 ? 147.248 120.119 135.889 1.00 28.42  ? 155 VAL   R N   1 
ATOM   984  C CA  . VAL   A 1 293 ? 145.803 119.936 135.825 1.00 18.16  ? 155 VAL   R CA  1 
ATOM   985  C C   . VAL   A 1 293 ? 145.103 121.144 135.211 1.00 24.01  ? 155 VAL   R C   1 
ATOM   986  O O   . VAL   A 1 293 ? 143.986 121.007 134.697 1.00 25.22  ? 155 VAL   R O   1 
ATOM   987  C CB  . VAL   A 1 293 ? 145.278 119.611 137.237 1.00 28.90  ? 155 VAL   R CB  1 
ATOM   988  C CG1 . VAL   A 1 293 ? 143.776 119.825 137.360 1.00 29.25  ? 155 VAL   R CG1 1 
ATOM   989  C CG2 . VAL   A 1 293 ? 145.645 118.187 137.618 1.00 35.60  ? 155 VAL   R CG2 1 
ATOM   990  N N   . VAL   A 1 294 ? 145.742 122.318 135.219 1.00 33.56  ? 156 VAL   R N   1 
ATOM   991  C CA  . VAL   A 1 294 ? 145.085 123.532 134.740 1.00 34.22  ? 156 VAL   R CA  1 
ATOM   992  C C   . VAL   A 1 294 ? 144.739 123.416 133.261 1.00 35.70  ? 156 VAL   R C   1 
ATOM   993  O O   . VAL   A 1 294 ? 143.628 123.766 132.842 1.00 37.50  ? 156 VAL   R O   1 
ATOM   994  C CB  . VAL   A 1 294 ? 145.959 124.768 135.024 1.00 32.10  ? 156 VAL   R CB  1 
ATOM   995  C CG1 . VAL   A 1 294 ? 147.387 124.532 134.576 1.00 34.75  ? 156 VAL   R CG1 1 
ATOM   996  C CG2 . VAL   A 1 294 ? 145.382 125.991 134.338 1.00 29.41  ? 156 VAL   R CG2 1 
ATOM   997  N N   . TYR   A 1 295 ? 145.675 122.922 132.447 1.00 44.07  ? 157 TYR   R N   1 
ATOM   998  C CA  . TYR   A 1 295 ? 145.407 122.779 131.019 1.00 38.04  ? 157 TYR   R CA  1 
ATOM   999  C C   . TYR   A 1 295 ? 144.251 121.820 130.774 1.00 42.12  ? 157 TYR   R C   1 
ATOM   1000 O O   . TYR   A 1 295 ? 143.297 122.157 130.065 1.00 44.55  ? 157 TYR   R O   1 
ATOM   1001 C CB  . TYR   A 1 295 ? 146.666 122.311 130.293 1.00 28.29  ? 157 TYR   R CB  1 
ATOM   1002 C CG  . TYR   A 1 295 ? 147.837 123.239 130.481 1.00 35.90  ? 157 TYR   R CG  1 
ATOM   1003 C CD1 . TYR   A 1 295 ? 147.811 124.527 129.970 1.00 40.49  ? 157 TYR   R CD1 1 
ATOM   1004 C CD2 . TYR   A 1 295 ? 148.966 122.832 131.172 1.00 31.38  ? 157 TYR   R CD2 1 
ATOM   1005 C CE1 . TYR   A 1 295 ? 148.879 125.383 130.141 1.00 40.29  ? 157 TYR   R CE1 1 
ATOM   1006 C CE2 . TYR   A 1 295 ? 150.038 123.680 131.348 1.00 33.27  ? 157 TYR   R CE2 1 
ATOM   1007 C CZ  . TYR   A 1 295 ? 149.989 124.955 130.832 1.00 38.42  ? 157 TYR   R CZ  1 
ATOM   1008 O OH  . TYR   A 1 295 ? 151.056 125.803 131.007 1.00 39.05  ? 157 TYR   R OH  1 
ATOM   1009 N N   . VAL   A 1 296 ? 144.291 120.646 131.407 1.00 41.04  ? 158 VAL   R N   1 
ATOM   1010 C CA  . VAL   A 1 296 ? 143.260 119.635 131.187 1.00 35.65  ? 158 VAL   R CA  1 
ATOM   1011 C C   . VAL   A 1 296 ? 141.906 120.123 131.683 1.00 38.34  ? 158 VAL   R C   1 
ATOM   1012 O O   . VAL   A 1 296 ? 140.860 119.741 131.146 1.00 40.87  ? 158 VAL   R O   1 
ATOM   1013 C CB  . VAL   A 1 296 ? 143.660 118.309 131.856 1.00 32.23  ? 158 VAL   R CB  1 
ATOM   1014 C CG1 . VAL   A 1 296 ? 142.896 117.157 131.234 1.00 35.73  ? 158 VAL   R CG1 1 
ATOM   1015 C CG2 . VAL   A 1 296 ? 145.154 118.083 131.730 1.00 35.87  ? 158 VAL   R CG2 1 
ATOM   1016 N N   . GLY   A 1 297 ? 141.895 120.958 132.717 1.00 32.14  ? 159 GLY   R N   1 
ATOM   1017 C CA  . GLY   A 1 297 ? 140.638 121.398 133.289 1.00 34.56  ? 159 GLY   R CA  1 
ATOM   1018 C C   . GLY   A 1 297 ? 140.062 122.653 132.669 1.00 39.65  ? 159 GLY   R C   1 
ATOM   1019 O O   . GLY   A 1 297 ? 138.876 122.946 132.845 1.00 43.38  ? 159 GLY   R O   1 
ATOM   1020 N N   . VAL   A 1 298 ? 140.886 123.403 131.939 1.00 42.04  ? 160 VAL   R N   1 
ATOM   1021 C CA  . VAL   A 1 298 ? 140.442 124.671 131.374 1.00 33.43  ? 160 VAL   R CA  1 
ATOM   1022 C C   . VAL   A 1 298 ? 140.418 124.607 129.853 1.00 38.67  ? 160 VAL   R C   1 
ATOM   1023 O O   . VAL   A 1 298 ? 139.366 124.789 129.230 1.00 44.23  ? 160 VAL   R O   1 
ATOM   1024 C CB  . VAL   A 1 298 ? 141.346 125.822 131.853 1.00 29.58  ? 160 VAL   R CB  1 
ATOM   1025 C CG1 . VAL   A 1 298 ? 141.034 127.097 131.094 1.00 36.12  ? 160 VAL   R CG1 1 
ATOM   1026 C CG2 . VAL   A 1 298 ? 141.193 126.030 133.347 1.00 28.37  ? 160 VAL   R CG2 1 
ATOM   1027 N N   . TRP   A 1 299 ? 141.576 124.348 129.244 1.00 32.42  ? 161 TRP   R N   1 
ATOM   1028 C CA  . TRP   A 1 299 ? 141.712 124.570 127.810 1.00 30.98  ? 161 TRP   R CA  1 
ATOM   1029 C C   . TRP   A 1 299 ? 141.089 123.440 127.001 1.00 38.60  ? 161 TRP   R C   1 
ATOM   1030 O O   . TRP   A 1 299 ? 140.375 123.694 126.025 1.00 45.01  ? 161 TRP   R O   1 
ATOM   1031 C CB  . TRP   A 1 299 ? 143.187 124.742 127.453 1.00 34.29  ? 161 TRP   R CB  1 
ATOM   1032 C CG  . TRP   A 1 299 ? 143.811 125.966 128.053 1.00 34.90  ? 161 TRP   R CG  1 
ATOM   1033 C CD1 . TRP   A 1 299 ? 144.703 126.009 129.083 1.00 37.96  ? 161 TRP   R CD1 1 
ATOM   1034 C CD2 . TRP   A 1 299 ? 143.601 127.325 127.651 1.00 35.99  ? 161 TRP   R CD2 1 
ATOM   1035 N NE1 . TRP   A 1 299 ? 145.056 127.308 129.352 1.00 35.19  ? 161 TRP   R NE1 1 
ATOM   1036 C CE2 . TRP   A 1 299 ? 144.394 128.135 128.485 1.00 34.22  ? 161 TRP   R CE2 1 
ATOM   1037 C CE3 . TRP   A 1 299 ? 142.817 127.935 126.668 1.00 43.81  ? 161 TRP   R CE3 1 
ATOM   1038 C CZ2 . TRP   A 1 299 ? 144.426 129.520 128.366 1.00 33.12  ? 161 TRP   R CZ2 1 
ATOM   1039 C CZ3 . TRP   A 1 299 ? 142.852 129.310 126.552 1.00 36.81  ? 161 TRP   R CZ3 1 
ATOM   1040 C CH2 . TRP   A 1 299 ? 143.649 130.087 127.396 1.00 29.46  ? 161 TRP   R CH2 1 
ATOM   1041 N N   . ILE   A 1 300 ? 141.348 122.188 127.384 1.00 33.43  ? 162 ILE   R N   1 
ATOM   1042 C CA  . ILE   A 1 300 ? 140.880 121.059 126.578 1.00 30.59  ? 162 ILE   R CA  1 
ATOM   1043 C C   . ILE   A 1 300 ? 139.359 120.990 126.498 1.00 36.18  ? 162 ILE   R C   1 
ATOM   1044 O O   . ILE   A 1 300 ? 138.830 120.845 125.383 1.00 38.20  ? 162 ILE   R O   1 
ATOM   1045 C CB  . ILE   A 1 300 ? 141.515 119.750 127.084 1.00 31.23  ? 162 ILE   R CB  1 
ATOM   1046 C CG1 . ILE   A 1 300 ? 142.962 119.649 126.602 1.00 31.43  ? 162 ILE   R CG1 1 
ATOM   1047 C CG2 . ILE   A 1 300 ? 140.721 118.550 126.604 1.00 32.36  ? 162 ILE   R CG2 1 
ATOM   1048 C CD1 . ILE   A 1 300 ? 143.678 118.417 127.088 1.00 37.34  ? 162 ILE   R CD1 1 
ATOM   1049 N N   . PRO   A 1 301 ? 138.601 121.070 127.600 1.00 38.77  ? 163 PRO   R N   1 
ATOM   1050 C CA  . PRO   A 1 301 ? 137.134 121.110 127.456 1.00 31.97  ? 163 PRO   R CA  1 
ATOM   1051 C C   . PRO   A 1 301 ? 136.641 122.313 126.675 1.00 33.86  ? 163 PRO   R C   1 
ATOM   1052 O O   . PRO   A 1 301 ? 135.664 122.199 125.926 1.00 33.43  ? 163 PRO   R O   1 
ATOM   1053 C CB  . PRO   A 1 301 ? 136.635 121.132 128.907 1.00 33.56  ? 163 PRO   R CB  1 
ATOM   1054 C CG  . PRO   A 1 301 ? 137.765 120.596 129.708 1.00 34.09  ? 163 PRO   R CG  1 
ATOM   1055 C CD  . PRO   A 1 301 ? 138.997 121.074 129.019 1.00 33.76  ? 163 PRO   R CD  1 
ATOM   1056 N N   . ALA   A 1 302 ? 137.300 123.466 126.820 1.00 36.08  ? 164 ALA   R N   1 
ATOM   1057 C CA  . ALA   A 1 302 ? 136.914 124.644 126.052 1.00 24.04  ? 164 ALA   R CA  1 
ATOM   1058 C C   . ALA   A 1 302 ? 137.101 124.411 124.560 1.00 31.03  ? 164 ALA   R C   1 
ATOM   1059 O O   . ALA   A 1 302 ? 136.234 124.767 123.755 1.00 37.94  ? 164 ALA   R O   1 
ATOM   1060 C CB  . ALA   A 1 302 ? 137.724 125.857 126.509 1.00 20.31  ? 164 ALA   R CB  1 
ATOM   1061 N N   . LEU   A 1 303 ? 138.228 123.810 124.173 1.00 33.56  ? 165 LEU   R N   1 
ATOM   1062 C CA  . LEU   A 1 303 ? 138.458 123.506 122.766 1.00 33.24  ? 165 LEU   R CA  1 
ATOM   1063 C C   . LEU   A 1 303 ? 137.468 122.466 122.258 1.00 30.01  ? 165 LEU   R C   1 
ATOM   1064 O O   . LEU   A 1 303 ? 136.964 122.579 121.135 1.00 42.26  ? 165 LEU   R O   1 
ATOM   1065 C CB  . LEU   A 1 303 ? 139.894 123.028 122.558 1.00 38.79  ? 165 LEU   R CB  1 
ATOM   1066 C CG  . LEU   A 1 303 ? 140.937 124.068 122.146 1.00 35.80  ? 165 LEU   R CG  1 
ATOM   1067 C CD1 . LEU   A 1 303 ? 141.112 125.133 123.213 1.00 34.41  ? 165 LEU   R CD1 1 
ATOM   1068 C CD2 . LEU   A 1 303 ? 142.263 123.393 121.847 1.00 38.39  ? 165 LEU   R CD2 1 
ATOM   1069 N N   . LEU   A 1 304 ? 137.175 121.448 123.067 1.00 25.14  ? 166 LEU   R N   1 
ATOM   1070 C CA  . LEU   A 1 304 ? 136.252 120.405 122.637 1.00 39.07  ? 166 LEU   R CA  1 
ATOM   1071 C C   . LEU   A 1 304 ? 134.808 120.891 122.576 1.00 42.26  ? 166 LEU   R C   1 
ATOM   1072 O O   . LEU   A 1 304 ? 133.989 120.272 121.890 1.00 41.77  ? 166 LEU   R O   1 
ATOM   1073 C CB  . LEU   A 1 304 ? 136.365 119.194 123.563 1.00 36.65  ? 166 LEU   R CB  1 
ATOM   1074 C CG  . LEU   A 1 304 ? 137.703 118.452 123.512 1.00 35.13  ? 166 LEU   R CG  1 
ATOM   1075 C CD1 . LEU   A 1 304 ? 137.692 117.251 124.440 1.00 35.26  ? 166 LEU   R CD1 1 
ATOM   1076 C CD2 . LEU   A 1 304 ? 138.034 118.034 122.091 1.00 34.10  ? 166 LEU   R CD2 1 
ATOM   1077 N N   . LEU   A 1 305 ? 134.477 121.971 123.280 1.00 46.99  ? 167 LEU   R N   1 
ATOM   1078 C CA  . LEU   A 1 305 ? 133.142 122.553 123.203 1.00 40.24  ? 167 LEU   R CA  1 
ATOM   1079 C C   . LEU   A 1 305 ? 132.954 123.454 121.990 1.00 38.75  ? 167 LEU   R C   1 
ATOM   1080 O O   . LEU   A 1 305 ? 131.840 123.939 121.771 1.00 46.63  ? 167 LEU   R O   1 
ATOM   1081 C CB  . LEU   A 1 305 ? 132.836 123.346 124.477 1.00 36.20  ? 167 LEU   R CB  1 
ATOM   1082 C CG  . LEU   A 1 305 ? 132.275 122.554 125.657 1.00 36.80  ? 167 LEU   R CG  1 
ATOM   1083 C CD1 . LEU   A 1 305 ? 132.503 123.300 126.957 1.00 31.80  ? 167 LEU   R CD1 1 
ATOM   1084 C CD2 . LEU   A 1 305 ? 130.798 122.277 125.450 1.00 43.65  ? 167 LEU   R CD2 1 
ATOM   1085 N N   . THR   A 1 306 ? 134.003 123.692 121.207 1.00 35.10  ? 168 THR   R N   1 
ATOM   1086 C CA  . THR   A 1 306 ? 133.923 124.547 120.031 1.00 37.32  ? 168 THR   R CA  1 
ATOM   1087 C C   . THR   A 1 306 ? 133.511 123.795 118.774 1.00 40.42  ? 168 THR   R C   1 
ATOM   1088 O O   . THR   A 1 306 ? 133.452 124.405 117.703 1.00 45.28  ? 168 THR   R O   1 
ATOM   1089 C CB  . THR   A 1 306 ? 135.264 125.241 119.783 1.00 39.83  ? 168 THR   R CB  1 
ATOM   1090 O OG1 . THR   A 1 306 ? 136.292 124.258 119.622 1.00 50.62  ? 168 THR   R OG1 1 
ATOM   1091 C CG2 . THR   A 1 306 ? 135.617 126.142 120.945 1.00 32.84  ? 168 THR   R CG2 1 
ATOM   1092 N N   . ILE   A 1 307 ? 133.246 122.490 118.871 1.00 42.43  ? 169 ILE   R N   1 
ATOM   1093 C CA  . ILE   A 1 307 ? 132.773 121.742 117.705 1.00 45.91  ? 169 ILE   R CA  1 
ATOM   1094 C C   . ILE   A 1 307 ? 131.486 122.328 117.134 1.00 46.44  ? 169 ILE   R C   1 
ATOM   1095 O O   . ILE   A 1 307 ? 131.392 122.470 115.903 1.00 47.65  ? 169 ILE   R O   1 
ATOM   1096 C CB  . ILE   A 1 307 ? 132.639 120.248 118.054 1.00 35.79  ? 169 ILE   R CB  1 
ATOM   1097 C CG1 . ILE   A 1 307 ? 134.007 119.649 118.369 1.00 34.91  ? 169 ILE   R CG1 1 
ATOM   1098 C CG2 . ILE   A 1 307 ? 131.977 119.492 116.919 1.00 40.12  ? 169 ILE   R CG2 1 
ATOM   1099 C CD1 . ILE   A 1 307 ? 133.930 118.340 119.114 1.00 39.39  ? 169 ILE   R CD1 1 
ATOM   1100 N N   . PRO   A 1 308 ? 130.472 122.676 117.936 1.00 44.81  ? 170 PRO   R N   1 
ATOM   1101 C CA  . PRO   A 1 308 ? 129.307 123.361 117.356 1.00 43.75  ? 170 PRO   R CA  1 
ATOM   1102 C C   . PRO   A 1 308 ? 129.659 124.674 116.687 1.00 52.35  ? 170 PRO   R C   1 
ATOM   1103 O O   . PRO   A 1 308 ? 128.979 125.074 115.737 1.00 57.07  ? 170 PRO   R O   1 
ATOM   1104 C CB  . PRO   A 1 308 ? 128.389 123.568 118.565 1.00 43.92  ? 170 PRO   R CB  1 
ATOM   1105 C CG  . PRO   A 1 308 ? 128.770 122.495 119.502 1.00 48.85  ? 170 PRO   R CG  1 
ATOM   1106 C CD  . PRO   A 1 308 ? 130.249 122.367 119.359 1.00 50.69  ? 170 PRO   R CD  1 
ATOM   1107 N N   . ASP   A 1 309 ? 130.697 125.366 117.160 1.00 50.46  ? 171 ASP   R N   1 
ATOM   1108 C CA  . ASP   A 1 309 ? 131.139 126.578 116.479 1.00 47.71  ? 171 ASP   R CA  1 
ATOM   1109 C C   . ASP   A 1 309 ? 131.755 126.257 115.125 1.00 43.37  ? 171 ASP   R C   1 
ATOM   1110 O O   . ASP   A 1 309 ? 131.556 126.996 114.156 1.00 47.46  ? 171 ASP   R O   1 
ATOM   1111 C CB  . ASP   A 1 309 ? 132.130 127.340 117.354 1.00 51.08  ? 171 ASP   R CB  1 
ATOM   1112 C CG  . ASP   A 1 309 ? 131.445 128.322 118.274 1.00 59.44  ? 171 ASP   R CG  1 
ATOM   1113 O OD1 . ASP   A 1 309 ? 130.251 128.605 118.053 1.00 58.09  ? 171 ASP   R OD1 1 
ATOM   1114 O OD2 . ASP   A 1 309 ? 132.096 128.810 119.218 1.00 55.76  ? 171 ASP   R OD2 1 
ATOM   1115 N N   . PHE   A 1 310 ? 132.508 125.160 115.036 1.00 36.15  ? 172 PHE   R N   1 
ATOM   1116 C CA  . PHE   A 1 310 ? 133.084 124.764 113.760 1.00 29.94  ? 172 PHE   R CA  1 
ATOM   1117 C C   . PHE   A 1 310 ? 132.031 124.264 112.785 1.00 35.05  ? 172 PHE   R C   1 
ATOM   1118 O O   . PHE   A 1 310 ? 132.222 124.385 111.571 1.00 40.26  ? 172 PHE   R O   1 
ATOM   1119 C CB  . PHE   A 1 310 ? 134.141 123.684 113.974 1.00 31.71  ? 172 PHE   R CB  1 
ATOM   1120 C CG  . PHE   A 1 310 ? 135.517 124.226 114.206 1.00 37.07  ? 172 PHE   R CG  1 
ATOM   1121 C CD1 . PHE   A 1 310 ? 136.219 124.831 113.181 1.00 38.41  ? 172 PHE   R CD1 1 
ATOM   1122 C CD2 . PHE   A 1 310 ? 136.109 124.133 115.452 1.00 38.58  ? 172 PHE   R CD2 1 
ATOM   1123 C CE1 . PHE   A 1 310 ? 137.488 125.331 113.393 1.00 37.88  ? 172 PHE   R CE1 1 
ATOM   1124 C CE2 . PHE   A 1 310 ? 137.376 124.632 115.671 1.00 41.83  ? 172 PHE   R CE2 1 
ATOM   1125 C CZ  . PHE   A 1 310 ? 138.066 125.231 114.640 1.00 40.33  ? 172 PHE   R CZ  1 
ATOM   1126 N N   . ILE   A 1 311 ? 130.929 123.712 113.281 1.00 43.63  ? 173 ILE   R N   1 
ATOM   1127 C CA  . ILE   A 1 311 ? 129.894 123.171 112.405 1.00 47.08  ? 173 ILE   R CA  1 
ATOM   1128 C C   . ILE   A 1 311 ? 128.906 124.246 111.972 1.00 49.34  ? 173 ILE   R C   1 
ATOM   1129 O O   . ILE   A 1 311 ? 128.582 124.366 110.788 1.00 48.73  ? 173 ILE   R O   1 
ATOM   1130 C CB  . ILE   A 1 311 ? 129.170 121.999 113.102 1.00 46.48  ? 173 ILE   R CB  1 
ATOM   1131 C CG1 . ILE   A 1 311 ? 130.141 120.857 113.392 1.00 46.74  ? 173 ILE   R CG1 1 
ATOM   1132 C CG2 . ILE   A 1 311 ? 128.010 121.505 112.254 1.00 44.84  ? 173 ILE   R CG2 1 
ATOM   1133 C CD1 . ILE   A 1 311 ? 129.501 119.694 114.111 1.00 48.58  ? 173 ILE   R CD1 1 
ATOM   1134 N N   . PHE   A 1 312 ? 128.416 125.052 112.915 1.00 46.21  ? 174 PHE   R N   1 
ATOM   1135 C CA  . PHE   A 1 312 ? 127.237 125.874 112.686 1.00 43.19  ? 174 PHE   R CA  1 
ATOM   1136 C C   . PHE   A 1 312 ? 127.534 127.332 112.363 1.00 48.41  ? 174 PHE   R C   1 
ATOM   1137 O O   . PHE   A 1 312 ? 126.660 128.009 111.812 1.00 50.80  ? 174 PHE   R O   1 
ATOM   1138 C CB  . PHE   A 1 312 ? 126.315 125.817 113.908 1.00 46.00  ? 174 PHE   R CB  1 
ATOM   1139 C CG  . PHE   A 1 312 ? 125.731 124.460 114.164 1.00 46.60  ? 174 PHE   R CG  1 
ATOM   1140 C CD1 . PHE   A 1 312 ? 124.976 123.824 113.194 1.00 47.74  ? 174 PHE   R CD1 1 
ATOM   1141 C CD2 . PHE   A 1 312 ? 125.926 123.826 115.375 1.00 43.38  ? 174 PHE   R CD2 1 
ATOM   1142 C CE1 . PHE   A 1 312 ? 124.433 122.579 113.426 1.00 45.40  ? 174 PHE   R CE1 1 
ATOM   1143 C CE2 . PHE   A 1 312 ? 125.386 122.581 115.612 1.00 44.62  ? 174 PHE   R CE2 1 
ATOM   1144 C CZ  . PHE   A 1 312 ? 124.638 121.958 114.636 1.00 46.20  ? 174 PHE   R CZ  1 
ATOM   1145 N N   . ALA   A 1 313 ? 128.718 127.842 112.693 1.00 47.84  ? 175 ALA   R N   1 
ATOM   1146 C CA  . ALA   A 1 313 ? 129.038 129.223 112.356 1.00 46.09  ? 175 ALA   R CA  1 
ATOM   1147 C C   . ALA   A 1 313 ? 129.166 129.371 110.845 1.00 49.26  ? 175 ALA   R C   1 
ATOM   1148 O O   . ALA   A 1 313 ? 129.874 128.599 110.193 1.00 56.45  ? 175 ALA   R O   1 
ATOM   1149 C CB  . ALA   A 1 313 ? 130.327 129.660 113.045 1.00 42.12  ? 175 ALA   R CB  1 
ATOM   1150 N N   . ASN   A 1 314 ? 128.479 130.365 110.288 1.00 46.85  ? 176 ASN   R N   1 
ATOM   1151 C CA  . ASN   A 1 314 ? 128.412 130.523 108.843 1.00 51.86  ? 176 ASN   R CA  1 
ATOM   1152 C C   . ASN   A 1 314 ? 128.101 131.972 108.503 1.00 55.05  ? 176 ASN   R C   1 
ATOM   1153 O O   . ASN   A 1 314 ? 127.782 132.782 109.376 1.00 56.74  ? 176 ASN   R O   1 
ATOM   1154 C CB  . ASN   A 1 314 ? 127.358 129.599 108.221 1.00 51.41  ? 176 ASN   R CB  1 
ATOM   1155 C CG  . ASN   A 1 314 ? 127.934 128.269 107.785 1.00 54.76  ? 176 ASN   R CG  1 
ATOM   1156 O OD1 . ASN   A 1 314 ? 128.862 128.216 106.979 1.00 56.52  ? 176 ASN   R OD1 1 
ATOM   1157 N ND2 . ASN   A 1 314 ? 127.381 127.183 108.312 1.00 53.24  ? 176 ASN   R ND2 1 
ATOM   1158 N N   . VAL   A 1 315 ? 128.202 132.287 107.214 1.00 55.30  ? 177 VAL   R N   1 
ATOM   1159 C CA  . VAL   A 1 315 ? 127.896 133.611 106.686 1.00 51.58  ? 177 VAL   R CA  1 
ATOM   1160 C C   . VAL   A 1 315 ? 126.695 133.482 105.760 1.00 53.19  ? 177 VAL   R C   1 
ATOM   1161 O O   . VAL   A 1 315 ? 126.751 132.763 104.755 1.00 57.89  ? 177 VAL   R O   1 
ATOM   1162 C CB  . VAL   A 1 315 ? 129.096 134.217 105.945 1.00 45.57  ? 177 VAL   R CB  1 
ATOM   1163 C CG1 . VAL   A 1 315 ? 128.665 135.442 105.164 1.00 45.55  ? 177 VAL   R CG1 1 
ATOM   1164 C CG2 . VAL   A 1 315 ? 130.198 134.567 106.924 1.00 51.42  ? 177 VAL   R CG2 1 
ATOM   1165 N N   . SER   A 1 316 ? 125.615 134.179 106.092 1.00 64.67  ? 178 SER   R N   1 
ATOM   1166 C CA  . SER   A 1 316 ? 124.407 134.149 105.284 1.00 66.99  ? 178 SER   R CA  1 
ATOM   1167 C C   . SER   A 1 316 ? 124.455 135.235 104.212 1.00 69.20  ? 178 SER   R C   1 
ATOM   1168 O O   . SER   A 1 316 ? 125.419 135.992 104.092 1.00 68.91  ? 178 SER   R O   1 
ATOM   1169 C CB  . SER   A 1 316 ? 123.169 134.318 106.160 1.00 66.52  ? 178 SER   R CB  1 
ATOM   1170 O OG  . SER   A 1 316 ? 121.993 134.369 105.372 1.00 69.85  ? 178 SER   R OG  1 
ATOM   1171 N N   . GLU   A 1 317 ? 123.389 135.299 103.420 1.00 78.15  ? 179 GLU   R N   1 
ATOM   1172 C CA  . GLU   A 1 317 ? 123.266 136.256 102.326 1.00 77.56  ? 179 GLU   R CA  1 
ATOM   1173 C C   . GLU   A 1 317 ? 121.879 136.886 102.394 1.00 78.73  ? 179 GLU   R C   1 
ATOM   1174 O O   . GLU   A 1 317 ? 121.056 136.759 101.488 1.00 80.61  ? 179 GLU   R O   1 
ATOM   1175 C CB  . GLU   A 1 317 ? 123.547 135.575 100.982 1.00 78.61  ? 179 GLU   R CB  1 
ATOM   1176 C CG  . GLU   A 1 317 ? 124.176 136.437 99.837  1.00 79.20  ? 179 GLU   R CG  1 
ATOM   1177 C CD  . GLU   A 1 317 ? 123.390 137.638 99.307  1.00 82.58  ? 179 GLU   R CD  1 
ATOM   1178 O OE1 . GLU   A 1 317 ? 122.228 137.864 99.670  1.00 83.55  ? 179 GLU   R OE1 1 
ATOM   1179 O OE2 . GLU   A 1 317 ? 123.971 138.385 98.494  1.00 82.24  ? 179 GLU   R OE2 1 
ATOM   1180 N N   . ALA   A 1 318 ? 121.549 137.447 103.554 1.00 84.92  ? 180 ALA   R N   1 
ATOM   1181 C CA  . ALA   A 1 318 ? 120.279 138.139 103.715 1.00 86.84  ? 180 ALA   R CA  1 
ATOM   1182 C C   . ALA   A 1 318 ? 120.234 139.379 102.821 1.00 88.10  ? 180 ALA   R C   1 
ATOM   1183 O O   . ALA   A 1 318 ? 121.188 139.707 102.109 1.00 88.64  ? 180 ALA   R O   1 
ATOM   1184 C CB  . ALA   A 1 318 ? 120.058 138.512 105.177 1.00 86.40  ? 180 ALA   R CB  1 
ATOM   1185 N N   . ASP   A 1 319 ? 119.104 140.080 102.863 1.00 96.12  ? 181 ASP   R N   1 
ATOM   1186 C CA  . ASP   A 1 319 ? 118.885 141.210 101.968 1.00 97.75  ? 181 ASP   R CA  1 
ATOM   1187 C C   . ASP   A 1 319 ? 119.898 142.319 102.222 1.00 97.10  ? 181 ASP   R C   1 
ATOM   1188 O O   . ASP   A 1 319 ? 120.083 142.759 103.361 1.00 95.90  ? 181 ASP   R O   1 
ATOM   1189 C CB  . ASP   A 1 319 ? 117.463 141.742 102.138 1.00 97.96  ? 181 ASP   R CB  1 
ATOM   1190 C CG  . ASP   A 1 319 ? 116.413 140.765 101.648 1.00 96.46  ? 181 ASP   R CG  1 
ATOM   1191 O OD1 . ASP   A 1 319 ? 116.788 139.754 101.018 1.00 96.05  ? 181 ASP   R OD1 1 
ATOM   1192 O OD2 . ASP   A 1 319 ? 115.213 141.010 101.890 1.00 96.30  ? 181 ASP   R OD2 1 
ATOM   1193 N N   . ASP   A 1 320 ? 120.558 142.757 101.150 1.00 93.47  ? 182 ASP   R N   1 
ATOM   1194 C CA  . ASP   A 1 320 ? 121.432 143.925 101.075 1.00 94.18  ? 182 ASP   R CA  1 
ATOM   1195 C C   . ASP   A 1 320 ? 122.746 143.771 101.834 1.00 94.70  ? 182 ASP   R C   1 
ATOM   1196 O O   . ASP   A 1 320 ? 123.602 144.658 101.728 1.00 95.26  ? 182 ASP   R O   1 
ATOM   1197 C CB  . ASP   A 1 320 ? 120.733 145.201 101.569 1.00 93.46  ? 182 ASP   R CB  1 
ATOM   1198 C CG  . ASP   A 1 320 ? 121.217 146.446 100.852 1.00 95.71  ? 182 ASP   R CG  1 
ATOM   1199 O OD1 . ASP   A 1 320 ? 121.978 146.310 99.871  1.00 97.35  ? 182 ASP   R OD1 1 
ATOM   1200 O OD2 . ASP   A 1 320 ? 120.838 147.560 101.270 1.00 95.19  ? 182 ASP   R OD2 1 
ATOM   1201 N N   . ARG   A 1 321 ? 122.952 142.683 102.576 1.00 71.56  ? 183 ARG   R N   1 
ATOM   1202 C CA  . ARG   A 1 321 ? 124.183 142.535 103.342 1.00 67.22  ? 183 ARG   R CA  1 
ATOM   1203 C C   . ARG   A 1 321 ? 124.340 141.091 103.795 1.00 68.42  ? 183 ARG   R C   1 
ATOM   1204 O O   . ARG   A 1 321 ? 123.392 140.302 103.767 1.00 71.91  ? 183 ARG   R O   1 
ATOM   1205 C CB  . ARG   A 1 321 ? 124.209 143.480 104.549 1.00 64.24  ? 183 ARG   R CB  1 
ATOM   1206 C CG  . ARG   A 1 321 ? 123.228 143.119 105.645 1.00 64.14  ? 183 ARG   R CG  1 
ATOM   1207 C CD  . ARG   A 1 321 ? 123.319 144.093 106.806 1.00 64.79  ? 183 ARG   R CD  1 
ATOM   1208 N NE  . ARG   A 1 321 ? 124.659 144.147 107.377 1.00 64.31  ? 183 ARG   R NE  1 
ATOM   1209 C CZ  . ARG   A 1 321 ? 125.020 143.522 108.489 1.00 66.96  ? 183 ARG   R CZ  1 
ATOM   1210 N NH1 . ARG   A 1 321 ? 124.164 142.785 109.176 1.00 67.04  ? 183 ARG   R NH1 1 
ATOM   1211 N NH2 . ARG   A 1 321 ? 126.271 143.640 108.923 1.00 63.94  ? 183 ARG   R NH2 1 
ATOM   1212 N N   . TYR   A 1 322 ? 125.558 140.762 104.215 1.00 63.58  ? 184 TYR   R N   1 
ATOM   1213 C CA  . TYR   A 1 322 ? 125.869 139.462 104.787 1.00 59.74  ? 184 TYR   R CA  1 
ATOM   1214 C C   . TYR   A 1 322 ? 125.665 139.487 106.296 1.00 60.22  ? 184 TYR   R C   1 
ATOM   1215 O O   . TYR   A 1 322 ? 125.725 140.541 106.933 1.00 65.32  ? 184 TYR   R O   1 
ATOM   1216 C CB  . TYR   A 1 322 ? 127.310 139.055 104.475 1.00 60.77  ? 184 TYR   R CB  1 
ATOM   1217 C CG  . TYR   A 1 322 ? 127.634 138.951 103.003 1.00 65.24  ? 184 TYR   R CG  1 
ATOM   1218 C CD1 . TYR   A 1 322 ? 126.647 138.660 102.071 1.00 68.29  ? 184 TYR   R CD1 1 
ATOM   1219 C CD2 . TYR   A 1 322 ? 128.933 139.127 102.547 1.00 64.81  ? 184 TYR   R CD2 1 
ATOM   1220 C CE1 . TYR   A 1 322 ? 126.945 138.560 100.725 1.00 67.23  ? 184 TYR   R CE1 1 
ATOM   1221 C CE2 . TYR   A 1 322 ? 129.240 139.028 101.206 1.00 66.42  ? 184 TYR   R CE2 1 
ATOM   1222 C CZ  . TYR   A 1 322 ? 128.244 138.744 100.299 1.00 67.05  ? 184 TYR   R CZ  1 
ATOM   1223 O OH  . TYR   A 1 322 ? 128.549 138.646 98.962  1.00 68.01  ? 184 TYR   R OH  1 
ATOM   1224 N N   . ILE   A 1 323 ? 125.419 138.310 106.864 1.00 53.53  ? 185 ILE   R N   1 
ATOM   1225 C CA  . ILE   A 1 323 ? 125.249 138.143 108.302 1.00 56.18  ? 185 ILE   R CA  1 
ATOM   1226 C C   . ILE   A 1 323 ? 126.147 137.005 108.762 1.00 57.18  ? 185 ILE   R C   1 
ATOM   1227 O O   . ILE   A 1 323 ? 126.154 135.932 108.151 1.00 64.04  ? 185 ILE   R O   1 
ATOM   1228 C CB  . ILE   A 1 323 ? 123.782 137.860 108.677 1.00 58.86  ? 185 ILE   R CB  1 
ATOM   1229 C CG1 . ILE   A 1 323 ? 122.883 139.015 108.236 1.00 60.23  ? 185 ILE   R CG1 1 
ATOM   1230 C CG2 . ILE   A 1 323 ? 123.648 137.623 110.169 1.00 59.17  ? 185 ILE   R CG2 1 
ATOM   1231 C CD1 . ILE   A 1 323 ? 121.415 138.769 108.484 1.00 58.54  ? 185 ILE   R CD1 1 
ATOM   1232 N N   . CYS   A 1 324 ? 126.900 137.236 109.832 1.00 44.68  ? 186 CYS   R N   1 
ATOM   1233 C CA  . CYS   A 1 324 ? 127.784 136.229 110.413 1.00 39.24  ? 186 CYS   R CA  1 
ATOM   1234 C C   . CYS   A 1 324 ? 127.211 135.825 111.767 1.00 50.06  ? 186 CYS   R C   1 
ATOM   1235 O O   . CYS   A 1 324 ? 127.333 136.564 112.747 1.00 60.11  ? 186 CYS   R O   1 
ATOM   1236 C CB  . CYS   A 1 324 ? 129.206 136.763 110.541 1.00 46.79  ? 186 CYS   R CB  1 
ATOM   1237 S SG  . CYS   A 1 324 ? 130.262 135.868 111.710 1.00 60.25  ? 186 CYS   R SG  1 
ATOM   1238 N N   . ASP   A 1 325 ? 126.584 134.653 111.816 1.00 48.38  ? 187 ASP   R N   1 
ATOM   1239 C CA  . ASP   A 1 325 ? 126.003 134.142 113.049 1.00 44.76  ? 187 ASP   R CA  1 
ATOM   1240 C C   . ASP   A 1 325 ? 125.886 132.630 112.944 1.00 46.29  ? 187 ASP   R C   1 
ATOM   1241 O O   . ASP   A 1 325 ? 125.872 132.068 111.847 1.00 50.40  ? 187 ASP   R O   1 
ATOM   1242 C CB  . ASP   A 1 325 ? 124.633 134.770 113.327 1.00 48.54  ? 187 ASP   R CB  1 
ATOM   1243 C CG  . ASP   A 1 325 ? 124.248 134.707 114.791 1.00 52.23  ? 187 ASP   R CG  1 
ATOM   1244 O OD1 . ASP   A 1 325 ? 125.100 134.322 115.618 1.00 50.53  ? 187 ASP   R OD1 1 
ATOM   1245 O OD2 . ASP   A 1 325 ? 123.090 135.043 115.116 1.00 51.95  ? 187 ASP   R OD2 1 
ATOM   1246 N N   . ARG   A 1 326 ? 125.802 131.979 114.101 1.00 48.09  ? 188 ARG   R N   1 
ATOM   1247 C CA  . ARG   A 1 326 ? 125.627 130.533 114.130 1.00 41.79  ? 188 ARG   R CA  1 
ATOM   1248 C C   . ARG   A 1 326 ? 124.239 130.169 113.626 1.00 40.75  ? 188 ARG   R C   1 
ATOM   1249 O O   . ARG   A 1 326 ? 123.238 130.745 114.059 1.00 43.88  ? 188 ARG   R O   1 
ATOM   1250 C CB  . ARG   A 1 326 ? 125.840 129.994 115.542 1.00 34.35  ? 188 ARG   R CB  1 
ATOM   1251 C CG  . ARG   A 1 326 ? 127.264 130.134 116.037 1.00 42.59  ? 188 ARG   R CG  1 
ATOM   1252 C CD  . ARG   A 1 326 ? 127.367 129.931 117.536 1.00 41.29  ? 188 ARG   R CD  1 
ATOM   1253 N NE  . ARG   A 1 326 ? 126.974 128.588 117.943 1.00 42.91  ? 188 ARG   R NE  1 
ATOM   1254 C CZ  . ARG   A 1 326 ? 127.511 127.932 118.962 1.00 48.65  ? 188 ARG   R CZ  1 
ATOM   1255 N NH1 . ARG   A 1 326 ? 128.477 128.462 119.692 1.00 49.01  ? 188 ARG   R NH1 1 
ATOM   1256 N NH2 . ARG   A 1 326 ? 127.067 126.714 119.255 1.00 52.77  ? 188 ARG   R NH2 1 
ATOM   1257 N N   . PHE   A 1 327 ? 124.180 129.211 112.708 1.00 42.85  ? 189 PHE   R N   1 
ATOM   1258 C CA  . PHE   A 1 327 ? 122.932 128.806 112.074 1.00 49.26  ? 189 PHE   R CA  1 
ATOM   1259 C C   . PHE   A 1 327 ? 122.654 127.350 112.423 1.00 48.65  ? 189 PHE   R C   1 
ATOM   1260 O O   . PHE   A 1 327 ? 123.418 126.457 112.045 1.00 49.30  ? 189 PHE   R O   1 
ATOM   1261 C CB  . PHE   A 1 327 ? 122.999 129.014 110.563 1.00 52.63  ? 189 PHE   R CB  1 
ATOM   1262 C CG  . PHE   A 1 327 ? 122.815 130.444 110.146 1.00 52.89  ? 189 PHE   R CG  1 
ATOM   1263 C CD1 . PHE   A 1 327 ? 121.577 131.055 110.252 1.00 51.74  ? 189 PHE   R CD1 1 
ATOM   1264 C CD2 . PHE   A 1 327 ? 123.878 131.178 109.650 1.00 53.75  ? 189 PHE   R CD2 1 
ATOM   1265 C CE1 . PHE   A 1 327 ? 121.404 132.371 109.874 1.00 53.64  ? 189 PHE   R CE1 1 
ATOM   1266 C CE2 . PHE   A 1 327 ? 123.710 132.494 109.269 1.00 54.96  ? 189 PHE   R CE2 1 
ATOM   1267 C CZ  . PHE   A 1 327 ? 122.471 133.091 109.382 1.00 54.34  ? 189 PHE   R CZ  1 
ATOM   1268 N N   . TYR   A 1 328 ? 121.560 127.120 113.139 1.00 47.47  ? 190 TYR   R N   1 
ATOM   1269 C CA  . TYR   A 1 328 ? 121.112 125.803 113.557 1.00 47.28  ? 190 TYR   R CA  1 
ATOM   1270 C C   . TYR   A 1 328 ? 119.903 125.374 112.741 1.00 53.47  ? 190 TYR   R C   1 
ATOM   1271 O O   . TYR   A 1 328 ? 119.235 126.204 112.118 1.00 59.22  ? 190 TYR   R O   1 
ATOM   1272 C CB  . TYR   A 1 328 ? 120.751 125.820 115.039 1.00 46.43  ? 190 TYR   R CB  1 
ATOM   1273 C CG  . TYR   A 1 328 ? 121.801 126.435 115.928 1.00 45.27  ? 190 TYR   R CG  1 
ATOM   1274 C CD1 . TYR   A 1 328 ? 122.971 125.758 116.227 1.00 46.06  ? 190 TYR   R CD1 1 
ATOM   1275 C CD2 . TYR   A 1 328 ? 121.613 127.689 116.481 1.00 48.40  ? 190 TYR   R CD2 1 
ATOM   1276 C CE1 . TYR   A 1 328 ? 123.926 126.320 117.046 1.00 44.74  ? 190 TYR   R CE1 1 
ATOM   1277 C CE2 . TYR   A 1 328 ? 122.559 128.256 117.299 1.00 46.30  ? 190 TYR   R CE2 1 
ATOM   1278 C CZ  . TYR   A 1 328 ? 123.713 127.570 117.577 1.00 40.29  ? 190 TYR   R CZ  1 
ATOM   1279 O OH  . TYR   A 1 328 ? 124.653 128.141 118.394 1.00 43.12  ? 190 TYR   R OH  1 
ATOM   1280 N N   . PRO   A 1 329 ? 119.601 124.072 112.709 1.00 56.13  ? 191 PRO   R N   1 
ATOM   1281 C CA  . PRO   A 1 329 ? 118.383 123.632 112.008 1.00 61.15  ? 191 PRO   R CA  1 
ATOM   1282 C C   . PRO   A 1 329 ? 117.105 124.264 112.539 1.00 63.40  ? 191 PRO   R C   1 
ATOM   1283 O O   . PRO   A 1 329 ? 116.188 124.536 111.753 1.00 62.18  ? 191 PRO   R O   1 
ATOM   1284 C CB  . PRO   A 1 329 ? 118.399 122.112 112.215 1.00 59.27  ? 191 PRO   R CB  1 
ATOM   1285 C CG  . PRO   A 1 329 ? 119.838 121.781 112.371 1.00 59.51  ? 191 PRO   R CG  1 
ATOM   1286 C CD  . PRO   A 1 329 ? 120.449 122.937 113.107 1.00 56.10  ? 191 PRO   R CD  1 
ATOM   1287 N N   . ASN   A 1 330 ? 117.014 124.509 113.844 1.00 69.44  ? 192 ASN   R N   1 
ATOM   1288 C CA  . ASN   A 1 330 ? 115.837 125.147 114.423 1.00 68.13  ? 192 ASN   R CA  1 
ATOM   1289 C C   . ASN   A 1 330 ? 116.221 125.757 115.766 1.00 67.63  ? 192 ASN   R C   1 
ATOM   1290 O O   . ASN   A 1 330 ? 117.355 125.620 116.232 1.00 69.43  ? 192 ASN   R O   1 
ATOM   1291 C CB  . ASN   A 1 330 ? 114.680 124.153 114.561 1.00 68.56  ? 192 ASN   R CB  1 
ATOM   1292 C CG  . ASN   A 1 330 ? 115.124 122.818 115.112 1.00 66.39  ? 192 ASN   R CG  1 
ATOM   1293 O OD1 . ASN   A 1 330 ? 115.473 122.704 116.285 1.00 64.81  ? 192 ASN   R OD1 1 
ATOM   1294 N ND2 . ASN   A 1 330 ? 115.111 121.795 114.266 1.00 65.92  ? 192 ASN   R ND2 1 
ATOM   1295 N N   . ASP   A 1 331 ? 115.255 126.433 116.391 1.00 71.51  ? 193 ASP   R N   1 
ATOM   1296 C CA  . ASP   A 1 331 ? 115.488 127.142 117.645 1.00 74.11  ? 193 ASP   R CA  1 
ATOM   1297 C C   . ASP   A 1 331 ? 115.719 126.215 118.832 1.00 72.87  ? 193 ASP   R C   1 
ATOM   1298 O O   . ASP   A 1 331 ? 116.184 126.685 119.878 1.00 75.49  ? 193 ASP   R O   1 
ATOM   1299 C CB  . ASP   A 1 331 ? 114.312 128.074 117.954 1.00 74.85  ? 193 ASP   R CB  1 
ATOM   1300 C CG  . ASP   A 1 331 ? 114.160 129.180 116.930 1.00 78.41  ? 193 ASP   R CG  1 
ATOM   1301 O OD1 . ASP   A 1 331 ? 115.191 129.736 116.496 1.00 77.00  ? 193 ASP   R OD1 1 
ATOM   1302 O OD2 . ASP   A 1 331 ? 113.009 129.497 116.562 1.00 81.08  ? 193 ASP   R OD2 1 
ATOM   1303 N N   . LEU   A 1 332 ? 115.400 124.925 118.707 1.00 59.57  ? 194 LEU   R N   1 
ATOM   1304 C CA  . LEU   A 1 332 ? 115.667 123.999 119.802 1.00 60.12  ? 194 LEU   R CA  1 
ATOM   1305 C C   . LEU   A 1 332 ? 117.157 123.935 120.105 1.00 60.34  ? 194 LEU   R C   1 
ATOM   1306 O O   . LEU   A 1 332 ? 117.562 123.890 121.272 1.00 57.97  ? 194 LEU   R O   1 
ATOM   1307 C CB  . LEU   A 1 332 ? 115.123 122.613 119.465 1.00 63.39  ? 194 LEU   R CB  1 
ATOM   1308 C CG  . LEU   A 1 332 ? 113.671 122.335 119.861 1.00 62.94  ? 194 LEU   R CG  1 
ATOM   1309 C CD1 . LEU   A 1 332 ? 113.448 120.845 120.073 1.00 60.47  ? 194 LEU   R CD1 1 
ATOM   1310 C CD2 . LEU   A 1 332 ? 113.282 123.123 121.104 1.00 60.99  ? 194 LEU   R CD2 1 
ATOM   1311 N N   . TRP   A 1 333 ? 117.990 123.936 119.062 1.00 57.84  ? 195 TRP   R N   1 
ATOM   1312 C CA  . TRP   A 1 333 ? 119.431 124.004 119.270 1.00 54.95  ? 195 TRP   R CA  1 
ATOM   1313 C C   . TRP   A 1 333 ? 119.823 125.307 119.951 1.00 53.97  ? 195 TRP   R C   1 
ATOM   1314 O O   . TRP   A 1 333 ? 120.734 125.327 120.784 1.00 57.85  ? 195 TRP   R O   1 
ATOM   1315 C CB  . TRP   A 1 333 ? 120.166 123.856 117.940 1.00 54.79  ? 195 TRP   R CB  1 
ATOM   1316 C CG  . TRP   A 1 333 ? 120.530 122.449 117.602 1.00 57.50  ? 195 TRP   R CG  1 
ATOM   1317 C CD1 . TRP   A 1 333 ? 121.710 121.822 117.869 1.00 58.05  ? 195 TRP   R CD1 1 
ATOM   1318 C CD2 . TRP   A 1 333 ? 119.707 121.488 116.935 1.00 59.87  ? 195 TRP   R CD2 1 
ATOM   1319 N NE1 . TRP   A 1 333 ? 121.674 120.530 117.407 1.00 59.40  ? 195 TRP   R NE1 1 
ATOM   1320 C CE2 . TRP   A 1 333 ? 120.454 120.300 116.830 1.00 60.66  ? 195 TRP   R CE2 1 
ATOM   1321 C CE3 . TRP   A 1 333 ? 118.410 121.518 116.416 1.00 58.80  ? 195 TRP   R CE3 1 
ATOM   1322 C CZ2 . TRP   A 1 333 ? 119.948 119.153 116.228 1.00 60.44  ? 195 TRP   R CZ2 1 
ATOM   1323 C CZ3 . TRP   A 1 333 ? 117.910 120.379 115.819 1.00 60.36  ? 195 TRP   R CZ3 1 
ATOM   1324 C CH2 . TRP   A 1 333 ? 118.677 119.212 115.729 1.00 60.98  ? 195 TRP   R CH2 1 
ATOM   1325 N N   . VAL   A 1 334 ? 119.151 126.407 119.607 1.00 52.00  ? 196 VAL   R N   1 
ATOM   1326 C CA  . VAL   A 1 334 ? 119.450 127.684 120.251 1.00 53.35  ? 196 VAL   R CA  1 
ATOM   1327 C C   . VAL   A 1 334 ? 119.187 127.590 121.747 1.00 58.59  ? 196 VAL   R C   1 
ATOM   1328 O O   . VAL   A 1 334 ? 120.011 128.010 122.568 1.00 60.26  ? 196 VAL   R O   1 
ATOM   1329 C CB  . VAL   A 1 334 ? 118.635 128.821 119.610 1.00 55.19  ? 196 VAL   R CB  1 
ATOM   1330 C CG1 . VAL   A 1 334 ? 119.136 130.163 120.105 1.00 54.53  ? 196 VAL   R CG1 1 
ATOM   1331 C CG2 . VAL   A 1 334 ? 118.713 128.748 118.098 1.00 57.07  ? 196 VAL   R CG2 1 
ATOM   1332 N N   . VAL   A 1 335 ? 118.037 127.025 122.121 1.00 63.19  ? 197 VAL   R N   1 
ATOM   1333 C CA  . VAL   A 1 335 ? 117.700 126.881 123.537 1.00 56.26  ? 197 VAL   R CA  1 
ATOM   1334 C C   . VAL   A 1 335 ? 118.696 125.961 124.233 1.00 51.28  ? 197 VAL   R C   1 
ATOM   1335 O O   . VAL   A 1 335 ? 119.147 126.241 125.351 1.00 49.81  ? 197 VAL   R O   1 
ATOM   1336 C CB  . VAL   A 1 335 ? 116.254 126.375 123.695 1.00 56.88  ? 197 VAL   R CB  1 
ATOM   1337 C CG1 . VAL   A 1 335 ? 115.928 126.150 125.159 1.00 53.34  ? 197 VAL   R CG1 1 
ATOM   1338 C CG2 . VAL   A 1 335 ? 115.278 127.361 123.079 1.00 55.77  ? 197 VAL   R CG2 1 
ATOM   1339 N N   . VAL   A 1 336 ? 119.056 124.851 123.582 1.00 51.23  ? 198 VAL   R N   1 
ATOM   1340 C CA  . VAL   A 1 336 ? 119.974 123.890 124.188 1.00 49.62  ? 198 VAL   R CA  1 
ATOM   1341 C C   . VAL   A 1 336 ? 121.337 124.526 124.432 1.00 48.72  ? 198 VAL   R C   1 
ATOM   1342 O O   . VAL   A 1 336 ? 121.925 124.377 125.510 1.00 50.40  ? 198 VAL   R O   1 
ATOM   1343 C CB  . VAL   A 1 336 ? 120.087 122.634 123.304 1.00 45.72  ? 198 VAL   R CB  1 
ATOM   1344 C CG1 . VAL   A 1 336 ? 121.336 121.847 123.653 1.00 47.05  ? 198 VAL   R CG1 1 
ATOM   1345 C CG2 . VAL   A 1 336 ? 118.847 121.770 123.450 1.00 48.64  ? 198 VAL   R CG2 1 
ATOM   1346 N N   . PHE   A 1 337 ? 121.858 125.251 123.442 1.00 49.70  ? 199 PHE   R N   1 
ATOM   1347 C CA  . PHE   A 1 337 ? 123.173 125.860 123.600 1.00 46.45  ? 199 PHE   R CA  1 
ATOM   1348 C C   . PHE   A 1 337 ? 123.140 127.022 124.580 1.00 47.21  ? 199 PHE   R C   1 
ATOM   1349 O O   . PHE   A 1 337 ? 124.111 127.233 125.312 1.00 54.59  ? 199 PHE   R O   1 
ATOM   1350 C CB  . PHE   A 1 337 ? 123.715 126.303 122.243 1.00 47.07  ? 199 PHE   R CB  1 
ATOM   1351 C CG  . PHE   A 1 337 ? 124.265 125.174 121.424 1.00 46.19  ? 199 PHE   R CG  1 
ATOM   1352 C CD1 . PHE   A 1 337 ? 125.385 124.484 121.843 1.00 49.54  ? 199 PHE   R CD1 1 
ATOM   1353 C CD2 . PHE   A 1 337 ? 123.651 124.790 120.247 1.00 46.57  ? 199 PHE   R CD2 1 
ATOM   1354 C CE1 . PHE   A 1 337 ? 125.885 123.440 121.101 1.00 47.10  ? 199 PHE   R CE1 1 
ATOM   1355 C CE2 . PHE   A 1 337 ? 124.148 123.745 119.501 1.00 50.94  ? 199 PHE   R CE2 1 
ATOM   1356 C CZ  . PHE   A 1 337 ? 125.265 123.070 119.928 1.00 48.19  ? 199 PHE   R CZ  1 
ATOM   1357 N N   . GLN   A 1 338 ? 122.035 127.769 124.634 1.00 51.22  ? 200 GLN   R N   1 
ATOM   1358 C CA  . GLN   A 1 338 ? 121.908 128.806 125.651 1.00 53.47  ? 200 GLN   R CA  1 
ATOM   1359 C C   . GLN   A 1 338 ? 121.924 128.203 127.048 1.00 58.07  ? 200 GLN   R C   1 
ATOM   1360 O O   . GLN   A 1 338 ? 122.602 128.716 127.946 1.00 59.50  ? 200 GLN   R O   1 
ATOM   1361 C CB  . GLN   A 1 338 ? 120.626 129.607 125.425 1.00 57.59  ? 200 GLN   R CB  1 
ATOM   1362 C CG  . GLN   A 1 338 ? 120.797 130.812 124.515 1.00 62.44  ? 200 GLN   R CG  1 
ATOM   1363 C CD  . GLN   A 1 338 ? 119.483 131.493 124.192 1.00 63.41  ? 200 GLN   R CD  1 
ATOM   1364 O OE1 . GLN   A 1 338 ? 118.411 130.999 124.541 1.00 66.52  ? 200 GLN   R OE1 1 
ATOM   1365 N NE2 . GLN   A 1 338 ? 119.559 132.634 123.518 1.00 55.97  ? 200 GLN   R NE2 1 
ATOM   1366 N N   . PHE   A 1 339 ? 121.197 127.099 127.247 1.00 64.08  ? 201 PHE   R N   1 
ATOM   1367 C CA  . PHE   A 1 339 ? 121.164 126.461 128.559 1.00 56.84  ? 201 PHE   R CA  1 
ATOM   1368 C C   . PHE   A 1 339 ? 122.521 125.878 128.931 1.00 46.38  ? 201 PHE   R C   1 
ATOM   1369 O O   . PHE   A 1 339 ? 122.946 125.975 130.087 1.00 55.29  ? 201 PHE   R O   1 
ATOM   1370 C CB  . PHE   A 1 339 ? 120.084 125.381 128.593 1.00 55.03  ? 201 PHE   R CB  1 
ATOM   1371 C CG  . PHE   A 1 339 ? 118.701 125.917 128.840 1.00 65.50  ? 201 PHE   R CG  1 
ATOM   1372 C CD1 . PHE   A 1 339 ? 118.519 127.183 129.372 1.00 63.36  ? 201 PHE   R CD1 1 
ATOM   1373 C CD2 . PHE   A 1 339 ? 117.583 125.160 128.534 1.00 66.95  ? 201 PHE   R CD2 1 
ATOM   1374 C CE1 . PHE   A 1 339 ? 117.252 127.681 129.598 1.00 60.21  ? 201 PHE   R CE1 1 
ATOM   1375 C CE2 . PHE   A 1 339 ? 116.311 125.654 128.759 1.00 65.17  ? 201 PHE   R CE2 1 
ATOM   1376 C CZ  . PHE   A 1 339 ? 116.147 126.915 129.291 1.00 62.10  ? 201 PHE   R CZ  1 
ATOM   1377 N N   . GLN   A 1 340 ? 123.220 125.274 127.970 1.00 39.22  ? 202 GLN   R N   1 
ATOM   1378 C CA  . GLN   A 1 340 ? 124.525 124.703 128.283 1.00 44.49  ? 202 GLN   R CA  1 
ATOM   1379 C C   . GLN   A 1 340 ? 125.552 125.795 128.562 1.00 38.48  ? 202 GLN   R C   1 
ATOM   1380 O O   . GLN   A 1 340 ? 126.422 125.629 129.424 1.00 43.64  ? 202 GLN   R O   1 
ATOM   1381 C CB  . GLN   A 1 340 ? 124.983 123.772 127.157 1.00 46.36  ? 202 GLN   R CB  1 
ATOM   1382 C CG  . GLN   A 1 340 ? 125.616 124.445 125.957 1.00 45.03  ? 202 GLN   R CG  1 
ATOM   1383 C CD  . GLN   A 1 340 ? 127.121 124.337 125.970 1.00 41.64  ? 202 GLN   R CD  1 
ATOM   1384 O OE1 . GLN   A 1 340 ? 127.677 123.365 126.475 1.00 41.09  ? 202 GLN   R OE1 1 
ATOM   1385 N NE2 . GLN   A 1 340 ? 127.792 125.339 125.420 1.00 46.36  ? 202 GLN   R NE2 1 
ATOM   1386 N N   . HIS   A 1 341 ? 125.460 126.927 127.857 1.00 42.28  ? 203 HIS   R N   1 
ATOM   1387 C CA  . HIS   A 1 341 ? 126.310 128.069 128.171 1.00 38.35  ? 203 HIS   R CA  1 
ATOM   1388 C C   . HIS   A 1 341 ? 126.022 128.577 129.575 1.00 39.89  ? 203 HIS   R C   1 
ATOM   1389 O O   . HIS   A 1 341 ? 126.945 128.796 130.367 1.00 45.70  ? 203 HIS   R O   1 
ATOM   1390 C CB  . HIS   A 1 341 ? 126.100 129.170 127.127 1.00 43.36  ? 203 HIS   R CB  1 
ATOM   1391 C CG  . HIS   A 1 341 ? 126.682 130.500 127.500 1.00 43.75  ? 203 HIS   R CG  1 
ATOM   1392 N ND1 . HIS   A 1 341 ? 126.284 131.674 126.897 1.00 44.66  ? 203 HIS   R ND1 1 
ATOM   1393 C CD2 . HIS   A 1 341 ? 127.644 130.845 128.389 1.00 44.61  ? 203 HIS   R CD2 1 
ATOM   1394 C CE1 . HIS   A 1 341 ? 126.961 132.684 127.411 1.00 40.81  ? 203 HIS   R CE1 1 
ATOM   1395 N NE2 . HIS   A 1 341 ? 127.789 132.208 128.323 1.00 46.96  ? 203 HIS   R NE2 1 
ATOM   1396 N N   . ILE   A 1 342 ? 124.741 128.743 129.912 1.00 41.21  ? 204 ILE   R N   1 
ATOM   1397 C CA  . ILE   A 1 342 ? 124.375 129.204 131.248 1.00 40.91  ? 204 ILE   R CA  1 
ATOM   1398 C C   . ILE   A 1 342 ? 124.962 128.274 132.299 1.00 43.66  ? 204 ILE   R C   1 
ATOM   1399 O O   . ILE   A 1 342 ? 125.618 128.717 133.247 1.00 45.86  ? 204 ILE   R O   1 
ATOM   1400 C CB  . ILE   A 1 342 ? 122.845 129.313 131.383 1.00 40.49  ? 204 ILE   R CB  1 
ATOM   1401 C CG1 . ILE   A 1 342 ? 122.360 130.689 130.931 1.00 43.76  ? 204 ILE   R CG1 1 
ATOM   1402 C CG2 . ILE   A 1 342 ? 122.411 129.070 132.818 1.00 34.68  ? 204 ILE   R CG2 1 
ATOM   1403 C CD1 . ILE   A 1 342 ? 120.926 130.694 130.447 1.00 46.50  ? 204 ILE   R CD1 1 
ATOM   1404 N N   . MET   A 1 343 ? 124.780 126.965 132.115 1.00 44.21  ? 205 MET   R N   1 
ATOM   1405 C CA  . MET   A 1 343 ? 125.287 125.998 133.081 1.00 32.88  ? 205 MET   R CA  1 
ATOM   1406 C C   . MET   A 1 343 ? 126.801 126.097 133.214 1.00 36.00  ? 205 MET   R C   1 
ATOM   1407 O O   . MET   A 1 343 ? 127.315 126.513 134.257 1.00 48.33  ? 205 MET   R O   1 
ATOM   1408 C CB  . MET   A 1 343 ? 124.871 124.585 132.673 1.00 32.91  ? 205 MET   R CB  1 
ATOM   1409 C CG  . MET   A 1 343 ? 125.153 123.535 133.725 1.00 43.71  ? 205 MET   R CG  1 
ATOM   1410 S SD  . MET   A 1 343 ? 123.738 123.266 134.809 1.00 62.27  ? 205 MET   R SD  1 
ATOM   1411 C CE  . MET   A 1 343 ? 122.471 122.847 133.616 1.00 42.80  ? 205 MET   R CE  1 
ATOM   1412 N N   . VAL   A 1 344 ? 127.526 125.782 132.137 1.00 35.74  ? 206 VAL   R N   1 
ATOM   1413 C CA  . VAL   A 1 344 ? 128.979 125.672 132.194 1.00 39.25  ? 206 VAL   R CA  1 
ATOM   1414 C C   . VAL   A 1 344 ? 129.653 126.994 132.542 1.00 36.76  ? 206 VAL   R C   1 
ATOM   1415 O O   . VAL   A 1 344 ? 130.781 126.995 133.045 1.00 29.80  ? 206 VAL   R O   1 
ATOM   1416 C CB  . VAL   A 1 344 ? 129.500 125.106 130.854 1.00 43.14  ? 206 VAL   R CB  1 
ATOM   1417 C CG1 . VAL   A 1 344 ? 131.001 124.878 130.896 1.00 36.67  ? 206 VAL   R CG1 1 
ATOM   1418 C CG2 . VAL   A 1 344 ? 128.785 123.806 130.521 1.00 41.25  ? 206 VAL   R CG2 1 
ATOM   1419 N N   . GLY   A 1 345 ? 128.993 128.128 132.312 1.00 33.69  ? 207 GLY   R N   1 
ATOM   1420 C CA  . GLY   A 1 345 ? 129.626 129.397 132.599 1.00 35.35  ? 207 GLY   R CA  1 
ATOM   1421 C C   . GLY   A 1 345 ? 129.130 130.105 133.842 1.00 34.77  ? 207 GLY   R C   1 
ATOM   1422 O O   . GLY   A 1 345 ? 129.702 131.126 134.232 1.00 43.46  ? 207 GLY   R O   1 
ATOM   1423 N N   . LEU   A 1 346 ? 128.081 129.597 134.475 1.00 29.29  ? 208 LEU   R N   1 
ATOM   1424 C CA  . LEU   A 1 346 ? 127.620 130.281 135.674 1.00 30.32  ? 208 LEU   R CA  1 
ATOM   1425 C C   . LEU   A 1 346 ? 127.436 129.362 136.871 1.00 35.24  ? 208 LEU   R C   1 
ATOM   1426 O O   . LEU   A 1 346 ? 127.726 129.773 137.996 1.00 44.34  ? 208 LEU   R O   1 
ATOM   1427 C CB  . LEU   A 1 346 ? 126.300 131.007 135.372 1.00 33.00  ? 208 LEU   R CB  1 
ATOM   1428 C CG  . LEU   A 1 346 ? 125.686 131.837 136.499 1.00 35.78  ? 208 LEU   R CG  1 
ATOM   1429 C CD1 . LEU   A 1 346 ? 126.524 133.070 136.768 1.00 36.79  ? 208 LEU   R CD1 1 
ATOM   1430 C CD2 . LEU   A 1 346 ? 124.255 132.221 136.165 1.00 37.29  ? 208 LEU   R CD2 1 
ATOM   1431 N N   . ILE   A 1 347 ? 126.967 128.132 136.667 1.00 25.61  ? 209 ILE   R N   1 
ATOM   1432 C CA  . ILE   A 1 347 ? 126.505 127.323 137.787 1.00 19.84  ? 209 ILE   R CA  1 
ATOM   1433 C C   . ILE   A 1 347 ? 127.642 126.488 138.358 1.00 29.76  ? 209 ILE   R C   1 
ATOM   1434 O O   . ILE   A 1 347 ? 127.980 126.620 139.539 1.00 45.91  ? 209 ILE   R O   1 
ATOM   1435 C CB  . ILE   A 1 347 ? 125.321 126.434 137.373 1.00 26.42  ? 209 ILE   R CB  1 
ATOM   1436 C CG1 . ILE   A 1 347 ? 124.098 127.301 137.070 1.00 27.18  ? 209 ILE   R CG1 1 
ATOM   1437 C CG2 . ILE   A 1 347 ? 125.002 125.432 138.467 1.00 29.88  ? 209 ILE   R CG2 1 
ATOM   1438 C CD1 . ILE   A 1 347 ? 122.821 126.520 136.888 1.00 31.55  ? 209 ILE   R CD1 1 
ATOM   1439 N N   . LEU   A 1 348 ? 128.235 125.620 137.539 1.00 29.05  ? 210 LEU   R N   1 
ATOM   1440 C CA  . LEU   A 1 348 ? 129.301 124.756 138.044 1.00 33.39  ? 210 LEU   R CA  1 
ATOM   1441 C C   . LEU   A 1 348 ? 130.497 125.544 138.567 1.00 35.76  ? 210 LEU   R C   1 
ATOM   1442 O O   . LEU   A 1 348 ? 130.900 125.314 139.723 1.00 43.55  ? 210 LEU   R O   1 
ATOM   1443 C CB  . LEU   A 1 348 ? 129.710 123.752 136.960 1.00 28.40  ? 210 LEU   R CB  1 
ATOM   1444 C CG  . LEU   A 1 348 ? 128.582 122.991 136.262 1.00 31.11  ? 210 LEU   R CG  1 
ATOM   1445 C CD1 . LEU   A 1 348 ? 129.147 121.975 135.286 1.00 33.56  ? 210 LEU   R CD1 1 
ATOM   1446 C CD2 . LEU   A 1 348 ? 127.679 122.313 137.276 1.00 33.02  ? 210 LEU   R CD2 1 
ATOM   1447 N N   . PRO   A 1 349 ? 131.100 126.474 137.813 1.00 24.99  ? 211 PRO   R N   1 
ATOM   1448 C CA  . PRO   A 1 349 ? 132.134 127.317 138.430 1.00 21.72  ? 211 PRO   R CA  1 
ATOM   1449 C C   . PRO   A 1 349 ? 131.579 128.162 139.553 1.00 32.48  ? 211 PRO   R C   1 
ATOM   1450 O O   . PRO   A 1 349 ? 132.271 128.411 140.546 1.00 42.19  ? 211 PRO   R O   1 
ATOM   1451 C CB  . PRO   A 1 349 ? 132.637 128.178 137.266 1.00 26.47  ? 211 PRO   R CB  1 
ATOM   1452 C CG  . PRO   A 1 349 ? 132.085 127.560 136.035 1.00 37.50  ? 211 PRO   R CG  1 
ATOM   1453 C CD  . PRO   A 1 349 ? 130.819 126.903 136.434 1.00 33.65  ? 211 PRO   R CD  1 
ATOM   1454 N N   . GLY   A 1 350 ? 130.328 128.601 139.421 1.00 30.52  ? 212 GLY   R N   1 
ATOM   1455 C CA  . GLY   A 1 350 ? 129.695 129.331 140.501 1.00 30.91  ? 212 GLY   R CA  1 
ATOM   1456 C C   . GLY   A 1 350 ? 129.564 128.499 141.760 1.00 30.13  ? 212 GLY   R C   1 
ATOM   1457 O O   . GLY   A 1 350 ? 129.808 128.988 142.861 1.00 34.05  ? 212 GLY   R O   1 
ATOM   1458 N N   . ILE   A 1 351 ? 129.193 127.226 141.613 1.00 19.64  ? 213 ILE   R N   1 
ATOM   1459 C CA  . ILE   A 1 351 ? 129.073 126.351 142.774 1.00 14.69  ? 213 ILE   R CA  1 
ATOM   1460 C C   . ILE   A 1 351 ? 130.435 126.112 143.413 1.00 24.17  ? 213 ILE   R C   1 
ATOM   1461 O O   . ILE   A 1 351 ? 130.572 126.143 144.643 1.00 34.28  ? 213 ILE   R O   1 
ATOM   1462 C CB  . ILE   A 1 351 ? 128.390 125.031 142.376 1.00 20.52  ? 213 ILE   R CB  1 
ATOM   1463 C CG1 . ILE   A 1 351 ? 126.874 125.215 142.327 1.00 24.89  ? 213 ILE   R CG1 1 
ATOM   1464 C CG2 . ILE   A 1 351 ? 128.751 123.923 143.346 1.00 28.57  ? 213 ILE   R CG2 1 
ATOM   1465 C CD1 . ILE   A 1 351 ? 126.126 123.971 141.913 1.00 29.60  ? 213 ILE   R CD1 1 
ATOM   1466 N N   . VAL   A 1 352 ? 131.464 125.872 142.595 1.00 25.79  ? 214 VAL   R N   1 
ATOM   1467 C CA  . VAL   A 1 352 ? 132.802 125.646 143.143 1.00 26.63  ? 214 VAL   R CA  1 
ATOM   1468 C C   . VAL   A 1 352 ? 133.283 126.879 143.904 1.00 28.52  ? 214 VAL   R C   1 
ATOM   1469 O O   . VAL   A 1 352 ? 133.790 126.779 145.030 1.00 35.83  ? 214 VAL   R O   1 
ATOM   1470 C CB  . VAL   A 1 352 ? 133.786 125.256 142.025 1.00 24.55  ? 214 VAL   R CB  1 
ATOM   1471 C CG1 . VAL   A 1 352 ? 135.190 125.131 142.581 1.00 22.36  ? 214 VAL   R CG1 1 
ATOM   1472 C CG2 . VAL   A 1 352 ? 133.358 123.958 141.376 1.00 23.86  ? 214 VAL   R CG2 1 
ATOM   1473 N N   . ILE   A 1 353 ? 133.118 128.060 143.303 1.00 20.69  ? 215 ILE   R N   1 
ATOM   1474 C CA  . ILE   A 1 353 ? 133.551 129.297 143.944 1.00 20.31  ? 215 ILE   R CA  1 
ATOM   1475 C C   . ILE   A 1 353 ? 132.749 129.556 145.214 1.00 35.21  ? 215 ILE   R C   1 
ATOM   1476 O O   . ILE   A 1 353 ? 133.306 129.963 146.238 1.00 41.08  ? 215 ILE   R O   1 
ATOM   1477 C CB  . ILE   A 1 353 ? 133.447 130.469 142.953 1.00 24.46  ? 215 ILE   R CB  1 
ATOM   1478 C CG1 . ILE   A 1 353 ? 134.465 130.305 141.827 1.00 32.81  ? 215 ILE   R CG1 1 
ATOM   1479 C CG2 . ILE   A 1 353 ? 133.668 131.788 143.662 1.00 30.63  ? 215 ILE   R CG2 1 
ATOM   1480 C CD1 . ILE   A 1 353 ? 134.171 131.145 140.614 1.00 35.19  ? 215 ILE   R CD1 1 
ATOM   1481 N N   . LEU   A 1 354 ? 131.435 129.323 145.169 1.00 34.99  ? 216 LEU   R N   1 
ATOM   1482 C CA  . LEU   A 1 354 ? 130.592 129.507 146.345 1.00 25.57  ? 216 LEU   R CA  1 
ATOM   1483 C C   . LEU   A 1 354 ? 131.057 128.635 147.499 1.00 31.77  ? 216 LEU   R C   1 
ATOM   1484 O O   . LEU   A 1 354 ? 131.242 129.122 148.618 1.00 42.28  ? 216 LEU   R O   1 
ATOM   1485 C CB  . LEU   A 1 354 ? 129.138 129.192 145.994 1.00 28.83  ? 216 LEU   R CB  1 
ATOM   1486 C CG  . LEU   A 1 354 ? 128.026 129.923 146.743 1.00 29.05  ? 216 LEU   R CG  1 
ATOM   1487 C CD1 . LEU   A 1 354 ? 128.452 131.322 147.115 1.00 28.33  ? 216 LEU   R CD1 1 
ATOM   1488 C CD2 . LEU   A 1 354 ? 126.763 129.953 145.900 1.00 33.79  ? 216 LEU   R CD2 1 
ATOM   1489 N N   . SER   A 1 355 ? 131.259 127.341 147.246 1.00 23.33  ? 217 SER   R N   1 
ATOM   1490 C CA  . SER   A 1 355 ? 131.680 126.443 148.317 1.00 29.38  ? 217 SER   R CA  1 
ATOM   1491 C C   . SER   A 1 355 ? 133.042 126.848 148.867 1.00 32.51  ? 217 SER   R C   1 
ATOM   1492 O O   . SER   A 1 355 ? 133.225 126.974 150.089 1.00 39.00  ? 217 SER   R O   1 
ATOM   1493 C CB  . SER   A 1 355 ? 131.714 125.003 147.809 1.00 34.48  ? 217 SER   R CB  1 
ATOM   1494 O OG  . SER   A 1 355 ? 130.464 124.630 147.260 1.00 39.36  ? 217 SER   R OG  1 
ATOM   1495 N N   . CYS   A 1 356 ? 134.010 127.074 147.973 1.00 28.71  ? 218 CYS   R N   1 
ATOM   1496 C CA  . CYS   A 1 356 ? 135.356 127.398 148.423 1.00 24.52  ? 218 CYS   R CA  1 
ATOM   1497 C C   . CYS   A 1 356 ? 135.372 128.682 149.236 1.00 33.24  ? 218 CYS   R C   1 
ATOM   1498 O O   . CYS   A 1 356 ? 136.004 128.744 150.295 1.00 46.50  ? 218 CYS   R O   1 
ATOM   1499 C CB  . CYS   A 1 356 ? 136.299 127.508 147.227 1.00 28.14  ? 218 CYS   R CB  1 
ATOM   1500 S SG  . CYS   A 1 356 ? 136.711 125.932 146.452 1.00 57.08  ? 218 CYS   R SG  1 
ATOM   1501 N N   . TYR   A 1 357 ? 134.659 129.712 148.780 1.00 27.35  ? 219 TYR   R N   1 
ATOM   1502 C CA  . TYR   A 1 357 ? 134.701 130.983 149.488 1.00 30.36  ? 219 TYR   R CA  1 
ATOM   1503 C C   . TYR   A 1 357 ? 133.845 130.978 150.745 1.00 32.90  ? 219 TYR   R C   1 
ATOM   1504 O O   . TYR   A 1 357 ? 134.161 131.701 151.690 1.00 41.41  ? 219 TYR   R O   1 
ATOM   1505 C CB  . TYR   A 1 357 ? 134.293 132.119 148.555 1.00 31.26  ? 219 TYR   R CB  1 
ATOM   1506 C CG  . TYR   A 1 357 ? 135.481 132.669 147.813 1.00 32.68  ? 219 TYR   R CG  1 
ATOM   1507 C CD1 . TYR   A 1 357 ? 136.360 133.544 148.427 1.00 36.10  ? 219 TYR   R CD1 1 
ATOM   1508 C CD2 . TYR   A 1 357 ? 135.749 132.278 146.514 1.00 33.30  ? 219 TYR   R CD2 1 
ATOM   1509 C CE1 . TYR   A 1 357 ? 137.458 134.032 147.758 1.00 35.94  ? 219 TYR   R CE1 1 
ATOM   1510 C CE2 . TYR   A 1 357 ? 136.843 132.761 145.840 1.00 30.23  ? 219 TYR   R CE2 1 
ATOM   1511 C CZ  . TYR   A 1 357 ? 137.694 133.637 146.463 1.00 35.43  ? 219 TYR   R CZ  1 
ATOM   1512 O OH  . TYR   A 1 357 ? 138.788 134.121 145.787 1.00 45.62  ? 219 TYR   R OH  1 
ATOM   1513 N N   . CYS   A 1 358 ? 132.785 130.173 150.802 1.00 28.80  ? 220 CYS   R N   1 
ATOM   1514 C CA  . CYS   A 1 358 ? 132.067 130.017 152.061 1.00 29.23  ? 220 CYS   R CA  1 
ATOM   1515 C C   . CYS   A 1 358 ? 132.977 129.414 153.121 1.00 30.53  ? 220 CYS   R C   1 
ATOM   1516 O O   . CYS   A 1 358 ? 133.060 129.920 154.248 1.00 42.03  ? 220 CYS   R O   1 
ATOM   1517 C CB  . CYS   A 1 358 ? 130.825 129.154 151.855 1.00 32.63  ? 220 CYS   R CB  1 
ATOM   1518 S SG  . CYS   A 1 358 ? 129.920 128.788 153.369 1.00 54.40  ? 220 CYS   R SG  1 
ATOM   1519 N N   . ILE   A 1 359 ? 133.706 128.353 152.761 1.00 34.91  ? 221 ILE   R N   1 
ATOM   1520 C CA  . ILE   A 1 359 ? 134.656 127.770 153.707 1.00 31.66  ? 221 ILE   R CA  1 
ATOM   1521 C C   . ILE   A 1 359 ? 135.744 128.779 154.064 1.00 33.67  ? 221 ILE   R C   1 
ATOM   1522 O O   . ILE   A 1 359 ? 136.138 128.905 155.231 1.00 42.11  ? 221 ILE   R O   1 
ATOM   1523 C CB  . ILE   A 1 359 ? 135.254 126.469 153.141 1.00 33.96  ? 221 ILE   R CB  1 
ATOM   1524 C CG1 . ILE   A 1 359 ? 134.145 125.493 152.751 1.00 37.65  ? 221 ILE   R CG1 1 
ATOM   1525 C CG2 . ILE   A 1 359 ? 136.179 125.828 154.155 1.00 28.86  ? 221 ILE   R CG2 1 
ATOM   1526 C CD1 . ILE   A 1 359 ? 133.184 125.179 153.868 1.00 37.29  ? 221 ILE   R CD1 1 
ATOM   1527 N N   . ILE   A 1 360 ? 136.236 129.522 153.069 1.00 24.94  ? 222 ILE   R N   1 
ATOM   1528 C CA  . ILE   A 1 360 ? 137.327 130.467 153.299 1.00 20.21  ? 222 ILE   R CA  1 
ATOM   1529 C C   . ILE   A 1 360 ? 136.897 131.563 154.266 1.00 35.21  ? 222 ILE   R C   1 
ATOM   1530 O O   . ILE   A 1 360 ? 137.626 131.905 155.203 1.00 46.78  ? 222 ILE   R O   1 
ATOM   1531 C CB  . ILE   A 1 360 ? 137.809 131.057 151.962 1.00 27.09  ? 222 ILE   R CB  1 
ATOM   1532 C CG1 . ILE   A 1 360 ? 138.810 130.122 151.296 1.00 33.33  ? 222 ILE   R CG1 1 
ATOM   1533 C CG2 . ILE   A 1 360 ? 138.443 132.420 152.171 1.00 34.57  ? 222 ILE   R CG2 1 
ATOM   1534 C CD1 . ILE   A 1 360 ? 139.450 130.722 150.074 1.00 36.97  ? 222 ILE   R CD1 1 
ATOM   1535 N N   . ILE   A 1 361 ? 135.713 132.137 154.052 1.00 34.21  ? 223 ILE   R N   1 
ATOM   1536 C CA  . ILE   A 1 361 ? 135.246 133.216 154.915 1.00 25.84  ? 223 ILE   R CA  1 
ATOM   1537 C C   . ILE   A 1 361 ? 134.934 132.690 156.309 1.00 29.74  ? 223 ILE   R C   1 
ATOM   1538 O O   . ILE   A 1 361 ? 135.200 133.365 157.310 1.00 31.90  ? 223 ILE   R O   1 
ATOM   1539 C CB  . ILE   A 1 361 ? 134.034 133.925 154.285 1.00 29.36  ? 223 ILE   R CB  1 
ATOM   1540 C CG1 . ILE   A 1 361 ? 134.421 134.539 152.939 1.00 32.67  ? 223 ILE   R CG1 1 
ATOM   1541 C CG2 . ILE   A 1 361 ? 133.494 134.995 155.215 1.00 36.37  ? 223 ILE   R CG2 1 
ATOM   1542 C CD1 . ILE   A 1 361 ? 135.273 135.777 153.055 1.00 33.08  ? 223 ILE   R CD1 1 
ATOM   1543 N N   . SER   A 1 362 ? 134.376 131.479 156.406 1.00 30.03  ? 224 SER   R N   1 
ATOM   1544 C CA  . SER   A 1 362 ? 134.180 130.888 157.725 1.00 27.30  ? 224 SER   R CA  1 
ATOM   1545 C C   . SER   A 1 362 ? 135.502 130.713 158.457 1.00 32.43  ? 224 SER   R C   1 
ATOM   1546 O O   . SER   A 1 362 ? 135.557 130.860 159.681 1.00 41.17  ? 224 SER   R O   1 
ATOM   1547 C CB  . SER   A 1 362 ? 133.464 129.545 157.602 1.00 32.05  ? 224 SER   R CB  1 
ATOM   1548 O OG  . SER   A 1 362 ? 133.567 128.810 158.808 1.00 35.06  ? 224 SER   R OG  1 
ATOM   1549 N N   . ARG   A 1 363 ? 136.574 130.397 157.729 1.00 35.63  ? 225 ARG   R N   1 
ATOM   1550 C CA  . ARG   A 1 363 ? 137.884 130.252 158.355 1.00 36.49  ? 225 ARG   R CA  1 
ATOM   1551 C C   . ARG   A 1 363 ? 138.522 131.595 158.692 1.00 32.16  ? 225 ARG   R C   1 
ATOM   1552 O O   . ARG   A 1 363 ? 139.290 131.685 159.656 1.00 34.80  ? 225 ARG   R O   1 
ATOM   1553 C CB  . ARG   A 1 363 ? 138.812 129.451 157.440 1.00 38.24  ? 225 ARG   R CB  1 
ATOM   1554 C CG  . ARG   A 1 363 ? 140.066 128.929 158.113 1.00 38.62  ? 225 ARG   R CG  1 
ATOM   1555 C CD  . ARG   A 1 363 ? 139.780 127.648 158.871 1.00 35.56  ? 225 ARG   R CD  1 
ATOM   1556 N NE  . ARG   A 1 363 ? 138.809 126.813 158.176 1.00 38.08  ? 225 ARG   R NE  1 
ATOM   1557 C CZ  . ARG   A 1 363 ? 138.088 125.864 158.757 1.00 42.68  ? 225 ARG   R CZ  1 
ATOM   1558 N NH1 . ARG   A 1 363 ? 138.214 125.593 160.045 1.00 43.09  ? 225 ARG   R NH1 1 
ATOM   1559 N NH2 . ARG   A 1 363 ? 137.218 125.172 158.028 1.00 41.84  ? 225 ARG   R NH2 1 
ATOM   1560 N N   . LEU   A 1 364 ? 138.227 132.640 157.917 1.00 32.12  ? 226 LEU   R N   1 
ATOM   1561 C CA  . LEU   A 1 364 ? 138.923 133.913 158.085 1.00 38.91  ? 226 LEU   R CA  1 
ATOM   1562 C C   . LEU   A 1 364 ? 138.424 134.676 159.305 1.00 42.18  ? 226 LEU   R C   1 
ATOM   1563 O O   . LEU   A 1 364 ? 139.212 135.324 160.001 1.00 42.26  ? 226 LEU   R O   1 
ATOM   1564 C CB  . LEU   A 1 364 ? 138.764 134.767 156.828 1.00 37.21  ? 226 LEU   R CB  1 
ATOM   1565 C CG  . LEU   A 1 364 ? 139.626 134.416 155.616 1.00 34.47  ? 226 LEU   R CG  1 
ATOM   1566 C CD1 . LEU   A 1 364 ? 139.296 135.331 154.455 1.00 34.58  ? 226 LEU   R CD1 1 
ATOM   1567 C CD2 . LEU   A 1 364 ? 141.094 134.505 155.959 1.00 44.54  ? 226 LEU   R CD2 1 
ATOM   1568 N N   . LYS   A 1 365 ? 137.123 134.624 159.574 1.00 43.69  ? 227 LYS   R N   1 
ATOM   1569 C CA  . LYS   A 1 365 ? 136.528 135.398 160.654 1.00 39.20  ? 227 LYS   R CA  1 
ATOM   1570 C C   . LYS   A 1 365 ? 136.494 134.652 161.980 1.00 41.01  ? 227 LYS   R C   1 
ATOM   1571 O O   . LYS   A 1 365 ? 136.019 135.212 162.972 1.00 49.39  ? 227 LYS   R O   1 
ATOM   1572 C CB  . LYS   A 1 365 ? 135.108 135.826 160.278 1.00 42.62  ? 227 LYS   R CB  1 
ATOM   1573 C CG  . LYS   A 1 365 ? 134.085 134.706 160.342 1.00 43.37  ? 227 LYS   R CG  1 
ATOM   1574 C CD  . LYS   A 1 365 ? 132.704 135.194 159.938 1.00 42.55  ? 227 LYS   R CD  1 
ATOM   1575 C CE  . LYS   A 1 365 ? 132.769 136.132 158.747 1.00 43.32  ? 227 LYS   R CE  1 
ATOM   1576 N NZ  . LYS   A 1 365 ? 131.424 136.662 158.392 1.00 44.54  ? 227 LYS   R NZ  1 
ATOM   1577 N N   . SER   A 1 366 ? 136.976 133.416 162.027 1.00 37.54  ? 228 SER   R N   1 
ATOM   1578 C CA  . SER   A 1 366 ? 136.979 132.639 163.257 1.00 43.11  ? 228 SER   R CA  1 
ATOM   1579 C C   . SER   A 1 366 ? 138.367 132.244 163.729 1.00 45.00  ? 228 SER   R C   1 
ATOM   1580 O O   . SER   A 1 366 ? 138.576 132.119 164.937 1.00 47.80  ? 228 SER   R O   1 
ATOM   1581 C CB  . SER   A 1 366 ? 136.138 131.364 163.090 1.00 49.06  ? 228 SER   R CB  1 
ATOM   1582 O OG  . SER   A 1 366 ? 136.865 130.363 162.403 1.00 54.18  ? 228 SER   R OG  1 
ATOM   1583 N N   . VAL   A 1 367 ? 139.314 132.043 162.822 1.00 44.03  ? 229 VAL   R N   1 
ATOM   1584 C CA  . VAL   A 1 367 ? 140.663 131.650 163.207 1.00 45.16  ? 229 VAL   R CA  1 
ATOM   1585 C C   . VAL   A 1 367 ? 141.426 132.879 163.674 1.00 44.25  ? 229 VAL   R C   1 
ATOM   1586 O O   . VAL   A 1 367 ? 141.485 133.895 162.972 1.00 39.40  ? 229 VAL   R O   1 
ATOM   1587 C CB  . VAL   A 1 367 ? 141.383 130.957 162.041 1.00 45.30  ? 229 VAL   R CB  1 
ATOM   1588 C CG1 . VAL   A 1 367 ? 142.863 130.840 162.334 1.00 47.53  ? 229 VAL   R CG1 1 
ATOM   1589 C CG2 . VAL   A 1 367 ? 140.784 129.588 161.796 1.00 48.36  ? 229 VAL   R CG2 1 
ATOM   1590 N N   . ARG   A 1 368 ? 142.007 132.791 164.872 1.00 56.79  ? 230 ARG   R N   1 
ATOM   1591 C CA  . ARG   A 1 368 ? 142.774 133.907 165.411 1.00 57.01  ? 230 ARG   R CA  1 
ATOM   1592 C C   . ARG   A 1 368 ? 143.993 134.210 164.550 1.00 57.29  ? 230 ARG   R C   1 
ATOM   1593 O O   . ARG   A 1 368 ? 144.324 135.378 164.318 1.00 63.02  ? 230 ARG   R O   1 
ATOM   1594 C CB  . ARG   A 1 368 ? 143.198 133.604 166.847 1.00 50.81  ? 230 ARG   R CB  1 
ATOM   1595 C CG  . ARG   A 1 368 ? 143.955 134.730 167.517 1.00 50.50  ? 230 ARG   R CG  1 
ATOM   1596 C CD  . ARG   A 1 368 ? 144.562 134.278 168.827 1.00 53.68  ? 230 ARG   R CD  1 
ATOM   1597 N NE  . ARG   A 1 368 ? 145.875 133.677 168.637 1.00 56.12  ? 230 ARG   R NE  1 
ATOM   1598 C CZ  . ARG   A 1 368 ? 147.021 134.299 168.870 1.00 57.91  ? 230 ARG   R CZ  1 
ATOM   1599 N NH1 . ARG   A 1 368 ? 147.054 135.546 169.307 1.00 56.94  ? 230 ARG   R NH1 1 
ATOM   1600 N NH2 . ARG   A 1 368 ? 148.164 133.653 168.658 1.00 55.98  ? 230 ARG   R NH2 1 
ATOM   1601 N N   . LEU   A 1 369 ? 144.673 133.175 164.068 1.00 52.41  ? 231 LEU   R N   1 
ATOM   1602 C CA  . LEU   A 1 369 ? 145.900 133.364 163.301 1.00 53.86  ? 231 LEU   R CA  1 
ATOM   1603 C C   . LEU   A 1 369 ? 146.053 132.186 162.351 1.00 56.71  ? 231 LEU   R C   1 
ATOM   1604 O O   . LEU   A 1 369 ? 146.255 131.054 162.799 1.00 57.43  ? 231 LEU   R O   1 
ATOM   1605 C CB  . LEU   A 1 369 ? 147.104 133.482 164.229 1.00 52.99  ? 231 LEU   R CB  1 
ATOM   1606 C CG  . LEU   A 1 369 ? 148.262 134.365 163.770 1.00 56.55  ? 231 LEU   R CG  1 
ATOM   1607 C CD1 . LEU   A 1 369 ? 147.763 135.748 163.399 1.00 56.27  ? 231 LEU   R CD1 1 
ATOM   1608 C CD2 . LEU   A 1 369 ? 149.317 134.450 164.858 1.00 57.32  ? 231 LEU   R CD2 1 
ATOM   1609 N N   . LEU   A 1 370 ? 145.946 132.449 161.052 1.00 56.99  ? 232 LEU   R N   1 
ATOM   1610 C CA  . LEU   A 1 370 ? 146.168 131.406 160.063 1.00 54.14  ? 232 LEU   R CA  1 
ATOM   1611 C C   . LEU   A 1 370 ? 147.626 130.969 160.082 1.00 54.40  ? 232 LEU   R C   1 
ATOM   1612 O O   . LEU   A 1 370 ? 148.530 131.758 160.371 1.00 58.61  ? 232 LEU   R O   1 
ATOM   1613 C CB  . LEU   A 1 370 ? 145.783 131.895 158.668 1.00 51.26  ? 232 LEU   R CB  1 
ATOM   1614 C CG  . LEU   A 1 370 ? 144.293 132.121 158.420 1.00 50.08  ? 232 LEU   R CG  1 
ATOM   1615 C CD1 . LEU   A 1 370 ? 144.066 132.685 157.032 1.00 47.39  ? 232 LEU   R CD1 1 
ATOM   1616 C CD2 . LEU   A 1 370 ? 143.526 130.828 158.606 1.00 53.46  ? 232 LEU   R CD2 1 
ATOM   1617 N N   . SER   A 1 371 ? 147.848 129.692 159.772 1.00 55.62  ? 233 SER   R N   1 
ATOM   1618 C CA  . SER   A 1 371 ? 149.168 129.063 159.856 1.00 57.04  ? 233 SER   R CA  1 
ATOM   1619 C C   . SER   A 1 371 ? 149.651 129.223 161.293 1.00 56.64  ? 233 SER   R C   1 
ATOM   1620 O O   . SER   A 1 371 ? 148.938 128.784 162.213 1.00 59.00  ? 233 SER   R O   1 
ATOM   1621 C CB  . SER   A 1 371 ? 150.079 129.643 158.773 1.00 59.43  ? 233 SER   R CB  1 
ATOM   1622 O OG  . SER   A 1 371 ? 149.652 129.242 157.484 1.00 61.57  ? 233 SER   R OG  1 
ATOM   1623 N N   . GLY   A 1 372 ? 150.808 129.827 161.546 1.00 61.16  ? 234 GLY   R N   1 
ATOM   1624 C CA  . GLY   A 1 372 ? 151.269 129.984 162.910 1.00 64.11  ? 234 GLY   R CA  1 
ATOM   1625 C C   . GLY   A 1 372 ? 151.942 131.310 163.196 1.00 67.43  ? 234 GLY   R C   1 
ATOM   1626 O O   . GLY   A 1 372 ? 152.384 131.553 164.323 1.00 71.30  ? 234 GLY   R O   1 
ATOM   1627 N N   . SER   A 1 373 ? 152.020 132.181 162.194 1.00 69.77  ? 235 SER   R N   1 
ATOM   1628 C CA  . SER   A 1 373 ? 152.688 133.466 162.332 1.00 70.05  ? 235 SER   R CA  1 
ATOM   1629 C C   . SER   A 1 373 ? 151.814 134.562 161.739 1.00 73.24  ? 235 SER   R C   1 
ATOM   1630 O O   . SER   A 1 373 ? 150.947 134.309 160.899 1.00 76.32  ? 235 SER   R O   1 
ATOM   1631 C CB  . SER   A 1 373 ? 154.066 133.461 161.657 1.00 72.05  ? 235 SER   R CB  1 
ATOM   1632 O OG  . SER   A 1 373 ? 153.955 133.200 160.269 1.00 71.17  ? 235 SER   R OG  1 
ATOM   1633 N N   . ARG   A 1 374 ? 152.053 135.793 162.198 1.00 70.08  ? 236 ARG   R N   1 
ATOM   1634 C CA  . ARG   A 1 374 ? 151.218 136.915 161.778 1.00 72.55  ? 236 ARG   R CA  1 
ATOM   1635 C C   . ARG   A 1 374 ? 151.482 137.298 160.326 1.00 74.74  ? 236 ARG   R C   1 
ATOM   1636 O O   . ARG   A 1 374 ? 150.557 137.700 159.607 1.00 75.47  ? 236 ARG   R O   1 
ATOM   1637 C CB  . ARG   A 1 374 ? 151.451 138.111 162.700 1.00 69.73  ? 236 ARG   R CB  1 
ATOM   1638 C CG  . ARG   A 1 374 ? 150.951 137.905 164.117 1.00 67.10  ? 236 ARG   R CG  1 
ATOM   1639 C CD  . ARG   A 1 374 ? 151.212 139.133 164.974 1.00 71.34  ? 236 ARG   R CD  1 
ATOM   1640 N NE  . ARG   A 1 374 ? 150.728 138.959 166.339 1.00 75.96  ? 236 ARG   R NE  1 
ATOM   1641 C CZ  . ARG   A 1 374 ? 150.860 139.861 167.302 1.00 74.54  ? 236 ARG   R CZ  1 
ATOM   1642 N NH1 . ARG   A 1 374 ? 151.462 141.019 167.087 1.00 73.42  ? 236 ARG   R NH1 1 
ATOM   1643 N NH2 . ARG   A 1 374 ? 150.375 139.594 168.511 1.00 71.58  ? 236 ARG   R NH2 1 
ATOM   1644 N N   . GLU   A 1 375 ? 152.736 137.192 159.879 1.00 71.67  ? 237 GLU   R N   1 
ATOM   1645 C CA  . GLU   A 1 375 ? 153.062 137.569 158.507 1.00 68.53  ? 237 GLU   R CA  1 
ATOM   1646 C C   . GLU   A 1 375 ? 152.348 136.674 157.503 1.00 69.45  ? 237 GLU   R C   1 
ATOM   1647 O O   . GLU   A 1 375 ? 151.842 137.156 156.482 1.00 71.10  ? 237 GLU   R O   1 
ATOM   1648 C CB  . GLU   A 1 375 ? 154.576 137.533 158.294 1.00 69.41  ? 237 GLU   R CB  1 
ATOM   1649 C CG  . GLU   A 1 375 ? 155.231 136.185 158.559 1.00 73.48  ? 237 GLU   R CG  1 
ATOM   1650 C CD  . GLU   A 1 375 ? 155.714 136.039 159.987 1.00 76.67  ? 237 GLU   R CD  1 
ATOM   1651 O OE1 . GLU   A 1 375 ? 155.219 136.779 160.863 1.00 76.48  ? 237 GLU   R OE1 1 
ATOM   1652 O OE2 . GLU   A 1 375 ? 156.591 135.184 160.234 1.00 73.34  ? 237 GLU   R OE2 1 
ATOM   1653 N N   . LYS   A 1 376 ? 152.287 135.369 157.778 1.00 64.26  ? 238 LYS   R N   1 
ATOM   1654 C CA  . LYS   A 1 376 ? 151.567 134.462 156.891 1.00 65.43  ? 238 LYS   R CA  1 
ATOM   1655 C C   . LYS   A 1 376 ? 150.085 134.807 156.845 1.00 65.26  ? 238 LYS   R C   1 
ATOM   1656 O O   . LYS   A 1 376 ? 149.468 134.794 155.773 1.00 71.49  ? 238 LYS   R O   1 
ATOM   1657 C CB  . LYS   A 1 376 ? 151.772 133.018 157.343 1.00 64.06  ? 238 LYS   R CB  1 
ATOM   1658 C CG  . LYS   A 1 376 ? 153.198 132.526 157.184 1.00 66.91  ? 238 LYS   R CG  1 
ATOM   1659 C CD  . LYS   A 1 376 ? 153.374 131.137 157.766 1.00 67.96  ? 238 LYS   R CD  1 
ATOM   1660 C CE  . LYS   A 1 376 ? 154.839 130.737 157.794 1.00 68.91  ? 238 LYS   R CE  1 
ATOM   1661 N NZ  . LYS   A 1 376 ? 155.052 129.464 158.535 1.00 68.25  ? 238 LYS   R NZ  1 
ATOM   1662 N N   . ASP   A 1 377 ? 149.501 135.132 157.999 1.00 54.92  ? 239 ASP   R N   1 
ATOM   1663 C CA  . ASP   A 1 377 ? 148.094 135.510 158.042 1.00 59.57  ? 239 ASP   R CA  1 
ATOM   1664 C C   . ASP   A 1 377 ? 147.832 136.750 157.193 1.00 66.27  ? 239 ASP   R C   1 
ATOM   1665 O O   . ASP   A 1 377 ? 146.914 136.766 156.360 1.00 66.01  ? 239 ASP   R O   1 
ATOM   1666 C CB  . ASP   A 1 377 ? 147.670 135.745 159.492 1.00 59.03  ? 239 ASP   R CB  1 
ATOM   1667 C CG  . ASP   A 1 377 ? 146.174 135.910 159.645 1.00 64.37  ? 239 ASP   R CG  1 
ATOM   1668 O OD1 . ASP   A 1 377 ? 145.434 135.536 158.713 1.00 71.89  ? 239 ASP   R OD1 1 
ATOM   1669 O OD2 . ASP   A 1 377 ? 145.736 136.415 160.699 1.00 61.29  ? 239 ASP   R OD2 1 
ATOM   1670 N N   . ARG   A 1 378 ? 148.641 137.797 157.379 1.00 67.92  ? 240 ARG   R N   1 
ATOM   1671 C CA  . ARG   A 1 378 ? 148.403 139.034 156.642 1.00 63.81  ? 240 ARG   R CA  1 
ATOM   1672 C C   . ARG   A 1 378 ? 148.650 138.847 155.150 1.00 63.91  ? 240 ARG   R C   1 
ATOM   1673 O O   . ARG   A 1 378 ? 147.928 139.419 154.324 1.00 67.65  ? 240 ARG   R O   1 
ATOM   1674 C CB  . ARG   A 1 378 ? 149.257 140.173 157.206 1.00 62.88  ? 240 ARG   R CB  1 
ATOM   1675 C CG  . ARG   A 1 378 ? 150.742 140.075 156.935 1.00 63.45  ? 240 ARG   R CG  1 
ATOM   1676 C CD  . ARG   A 1 378 ? 151.468 141.306 157.443 1.00 62.68  ? 240 ARG   R CD  1 
ATOM   1677 N NE  . ARG   A 1 378 ? 152.910 141.101 157.498 1.00 67.55  ? 240 ARG   R NE  1 
ATOM   1678 C CZ  . ARG   A 1 378 ? 153.735 141.303 156.481 1.00 70.17  ? 240 ARG   R CZ  1 
ATOM   1679 N NH1 . ARG   A 1 378 ? 153.294 141.714 155.303 1.00 65.45  ? 240 ARG   R NH1 1 
ATOM   1680 N NH2 . ARG   A 1 378 ? 155.037 141.086 156.649 1.00 71.45  ? 240 ARG   R NH2 1 
ATOM   1681 N N   . ASN   A 1 379 ? 149.646 138.037 154.779 1.00 52.41  ? 241 ASN   R N   1 
ATOM   1682 C CA  . ASN   A 1 379 ? 149.853 137.739 153.367 1.00 48.86  ? 241 ASN   R CA  1 
ATOM   1683 C C   . ASN   A 1 379 ? 148.647 137.024 152.778 1.00 49.54  ? 241 ASN   R C   1 
ATOM   1684 O O   . ASN   A 1 379 ? 148.203 137.347 151.671 1.00 58.95  ? 241 ASN   R O   1 
ATOM   1685 C CB  . ASN   A 1 379 ? 151.115 136.899 153.181 1.00 51.79  ? 241 ASN   R CB  1 
ATOM   1686 C CG  . ASN   A 1 379 ? 152.377 137.731 153.217 1.00 58.33  ? 241 ASN   R CG  1 
ATOM   1687 O OD1 . ASN   A 1 379 ? 152.385 138.886 152.794 1.00 60.25  ? 241 ASN   R OD1 1 
ATOM   1688 N ND2 . ASN   A 1 379 ? 153.458 137.145 153.720 1.00 60.68  ? 241 ASN   R ND2 1 
ATOM   1689 N N   . LEU   A 1 380 ? 148.095 136.053 153.508 1.00 47.24  ? 242 LEU   R N   1 
ATOM   1690 C CA  . LEU   A 1 380 ? 146.933 135.336 153.000 1.00 45.92  ? 242 LEU   R CA  1 
ATOM   1691 C C   . LEU   A 1 380 ? 145.756 136.279 152.789 1.00 50.71  ? 242 LEU   R C   1 
ATOM   1692 O O   . LEU   A 1 380 ? 145.076 136.208 151.759 1.00 50.13  ? 242 LEU   R O   1 
ATOM   1693 C CB  . LEU   A 1 380 ? 146.558 134.201 153.950 1.00 49.19  ? 242 LEU   R CB  1 
ATOM   1694 C CG  . LEU   A 1 380 ? 147.507 133.002 153.940 1.00 49.68  ? 242 LEU   R CG  1 
ATOM   1695 C CD1 . LEU   A 1 380 ? 146.977 131.883 154.818 1.00 50.02  ? 242 LEU   R CD1 1 
ATOM   1696 C CD2 . LEU   A 1 380 ? 147.732 132.513 152.521 1.00 52.83  ? 242 LEU   R CD2 1 
ATOM   1697 N N   . ARG   A 1 381 ? 145.510 137.184 153.741 1.00 49.00  ? 243 ARG   R N   1 
ATOM   1698 C CA  . ARG   A 1 381 ? 144.410 138.135 153.572 1.00 45.25  ? 243 ARG   R CA  1 
ATOM   1699 C C   . ARG   A 1 381 ? 144.652 139.056 152.377 1.00 54.81  ? 243 ARG   R C   1 
ATOM   1700 O O   . ARG   A 1 381 ? 143.744 139.307 151.568 1.00 59.34  ? 243 ARG   R O   1 
ATOM   1701 C CB  . ARG   A 1 381 ? 144.214 138.964 154.842 1.00 50.47  ? 243 ARG   R CB  1 
ATOM   1702 C CG  . ARG   A 1 381 ? 144.311 138.188 156.135 1.00 50.80  ? 243 ARG   R CG  1 
ATOM   1703 C CD  . ARG   A 1 381 ? 142.990 137.567 156.532 1.00 51.09  ? 243 ARG   R CD  1 
ATOM   1704 N NE  . ARG   A 1 381 ? 143.143 136.714 157.704 1.00 54.08  ? 243 ARG   R NE  1 
ATOM   1705 C CZ  . ARG   A 1 381 ? 142.516 136.901 158.856 1.00 49.26  ? 243 ARG   R CZ  1 
ATOM   1706 N NH1 . ARG   A 1 381 ? 141.661 137.895 159.023 1.00 52.58  ? 243 ARG   R NH1 1 
ATOM   1707 N NH2 . ARG   A 1 381 ? 142.746 136.064 159.863 1.00 49.26  ? 243 ARG   R NH2 1 
ATOM   1708 N N   . ARG   A 1 382 ? 145.879 139.574 152.255 1.00 56.22  ? 244 ARG   R N   1 
ATOM   1709 C CA  . ARG   A 1 382 ? 146.181 140.556 151.221 1.00 47.46  ? 244 ARG   R CA  1 
ATOM   1710 C C   . ARG   A 1 382 ? 146.162 139.944 149.828 1.00 45.99  ? 244 ARG   R C   1 
ATOM   1711 O O   . ARG   A 1 382 ? 145.924 140.655 148.847 1.00 57.22  ? 244 ARG   R O   1 
ATOM   1712 C CB  . ARG   A 1 382 ? 147.536 141.202 151.500 1.00 47.25  ? 244 ARG   R CB  1 
ATOM   1713 C CG  . ARG   A 1 382 ? 147.805 142.461 150.698 1.00 55.70  ? 244 ARG   R CG  1 
ATOM   1714 C CD  . ARG   A 1 382 ? 148.905 143.312 151.324 1.00 54.84  ? 244 ARG   R CD  1 
ATOM   1715 N NE  . ARG   A 1 382 ? 148.972 143.188 152.777 1.00 54.91  ? 244 ARG   R NE  1 
ATOM   1716 C CZ  . ARG   A 1 382 ? 148.069 143.672 153.620 1.00 57.34  ? 244 ARG   R CZ  1 
ATOM   1717 N NH1 . ARG   A 1 382 ? 147.009 144.340 153.193 1.00 59.14  ? 244 ARG   R NH1 1 
ATOM   1718 N NH2 . ARG   A 1 382 ? 148.236 143.486 154.926 1.00 52.59  ? 244 ARG   R NH2 1 
ATOM   1719 N N   . ILE   A 1 383 ? 146.421 138.644 149.712 1.00 40.56  ? 245 ILE   R N   1 
ATOM   1720 C CA  . ILE   A 1 383 ? 146.292 137.994 148.413 1.00 42.65  ? 245 ILE   R CA  1 
ATOM   1721 C C   . ILE   A 1 383 ? 144.870 137.496 148.160 1.00 44.35  ? 245 ILE   R C   1 
ATOM   1722 O O   . ILE   A 1 383 ? 144.455 137.379 147.002 1.00 44.52  ? 245 ILE   R O   1 
ATOM   1723 C CB  . ILE   A 1 383 ? 147.317 136.855 148.270 1.00 44.33  ? 245 ILE   R CB  1 
ATOM   1724 C CG1 . ILE   A 1 383 ? 148.704 137.328 148.698 1.00 47.11  ? 245 ILE   R CG1 1 
ATOM   1725 C CG2 . ILE   A 1 383 ? 147.376 136.356 146.838 1.00 42.44  ? 245 ILE   R CG2 1 
ATOM   1726 C CD1 . ILE   A 1 383 ? 149.747 136.240 148.678 1.00 44.02  ? 245 ILE   R CD1 1 
ATOM   1727 N N   . THR   A 1 384 ? 144.099 137.214 149.212 1.00 42.83  ? 246 THR   R N   1 
ATOM   1728 C CA  . THR   A 1 384 ? 142.742 136.721 149.009 1.00 38.34  ? 246 THR   R CA  1 
ATOM   1729 C C   . THR   A 1 384 ? 141.777 137.831 148.612 1.00 44.87  ? 246 THR   R C   1 
ATOM   1730 O O   . THR   A 1 384 ? 140.864 137.597 147.813 1.00 45.51  ? 246 THR   R O   1 
ATOM   1731 C CB  . THR   A 1 384 ? 142.242 136.022 150.273 1.00 46.13  ? 246 THR   R CB  1 
ATOM   1732 O OG1 . THR   A 1 384 ? 143.283 135.197 150.810 1.00 48.82  ? 246 THR   R OG1 1 
ATOM   1733 C CG2 . THR   A 1 384 ? 141.029 135.161 149.961 1.00 42.97  ? 246 THR   R CG2 1 
ATOM   1734 N N   . ARG   A 1 385 ? 141.949 139.036 149.163 1.00 50.03  ? 247 ARG   R N   1 
ATOM   1735 C CA  . ARG   A 1 385 ? 140.957 140.092 148.942 1.00 48.44  ? 247 ARG   R CA  1 
ATOM   1736 C C   . ARG   A 1 385 ? 140.785 140.495 147.475 1.00 49.99  ? 247 ARG   R C   1 
ATOM   1737 O O   . ARG   A 1 385 ? 139.629 140.574 147.011 1.00 50.52  ? 247 ARG   R O   1 
ATOM   1738 C CB  . ARG   A 1 385 ? 141.304 141.294 149.825 1.00 41.89  ? 247 ARG   R CB  1 
ATOM   1739 C CG  . ARG   A 1 385 ? 140.420 142.508 149.614 1.00 49.64  ? 247 ARG   R CG  1 
ATOM   1740 C CD  . ARG   A 1 385 ? 141.255 143.716 149.240 1.00 54.41  ? 247 ARG   R CD  1 
ATOM   1741 N NE  . ARG   A 1 385 ? 142.287 143.972 150.238 1.00 57.61  ? 247 ARG   R NE  1 
ATOM   1742 C CZ  . ARG   A 1 385 ? 143.456 144.543 149.981 1.00 56.12  ? 247 ARG   R CZ  1 
ATOM   1743 N NH1 . ARG   A 1 385 ? 143.786 144.923 148.758 1.00 56.11  ? 247 ARG   R NH1 1 
ATOM   1744 N NH2 . ARG   A 1 385 ? 144.316 144.733 150.976 1.00 52.67  ? 247 ARG   R NH2 1 
ATOM   1745 N N   . PRO   A 1 386 ? 141.844 140.769 146.702 1.00 42.74  ? 248 PRO   R N   1 
ATOM   1746 C CA  . PRO   A 1 386 ? 141.628 141.149 145.297 1.00 34.43  ? 248 PRO   R CA  1 
ATOM   1747 C C   . PRO   A 1 386 ? 140.907 140.093 144.486 1.00 39.68  ? 248 PRO   R C   1 
ATOM   1748 O O   . PRO   A 1 386 ? 140.146 140.443 143.578 1.00 48.75  ? 248 PRO   R O   1 
ATOM   1749 C CB  . PRO   A 1 386 ? 143.051 141.384 144.774 1.00 37.65  ? 248 PRO   R CB  1 
ATOM   1750 C CG  . PRO   A 1 386 ? 143.850 141.682 145.980 1.00 43.52  ? 248 PRO   R CG  1 
ATOM   1751 C CD  . PRO   A 1 386 ? 143.274 140.819 147.051 1.00 49.42  ? 248 PRO   R CD  1 
ATOM   1752 N N   . THR   A 1 387 ? 141.127 138.809 144.776 1.00 44.03  ? 249 THR   R N   1 
ATOM   1753 C CA  . THR   A 1 387 ? 140.389 137.762 144.077 1.00 46.26  ? 249 THR   R CA  1 
ATOM   1754 C C   . THR   A 1 387 ? 138.900 137.853 144.374 1.00 43.68  ? 249 THR   R C   1 
ATOM   1755 O O   . THR   A 1 387 ? 138.067 137.638 143.485 1.00 46.24  ? 249 THR   R O   1 
ATOM   1756 C CB  . THR   A 1 387 ? 140.927 136.386 144.463 1.00 42.43  ? 249 THR   R CB  1 
ATOM   1757 O OG1 . THR   A 1 387 ? 140.401 136.008 145.740 1.00 44.02  ? 249 THR   R OG1 1 
ATOM   1758 C CG2 . THR   A 1 387 ? 142.444 136.405 144.528 1.00 45.63  ? 249 THR   R CG2 1 
ATOM   1759 N N   . VAL   A 1 388 ? 138.545 138.170 145.620 1.00 36.66  ? 250 VAL   R N   1 
ATOM   1760 C CA  . VAL   A 1 388 ? 137.139 138.355 145.969 1.00 37.27  ? 250 VAL   R CA  1 
ATOM   1761 C C   . VAL   A 1 388 ? 136.543 139.497 145.160 1.00 45.17  ? 250 VAL   R C   1 
ATOM   1762 O O   . VAL   A 1 388 ? 135.452 139.374 144.581 1.00 48.18  ? 250 VAL   R O   1 
ATOM   1763 C CB  . VAL   A 1 388 ? 136.988 138.605 147.479 1.00 33.46  ? 250 VAL   R CB  1 
ATOM   1764 C CG1 . VAL   A 1 388 ? 135.526 138.709 147.843 1.00 39.01  ? 250 VAL   R CG1 1 
ATOM   1765 C CG2 . VAL   A 1 388 ? 137.657 137.501 148.268 1.00 37.53  ? 250 VAL   R CG2 1 
ATOM   1766 N N   . ILE   A 1 389 ? 137.259 140.624 145.097 1.00 42.14  ? 251 ILE   R N   1 
ATOM   1767 C CA  . ILE   A 1 389 ? 136.748 141.768 144.341 1.00 34.87  ? 251 ILE   R CA  1 
ATOM   1768 C C   . ILE   A 1 389 ? 136.588 141.409 142.868 1.00 44.39  ? 251 ILE   R C   1 
ATOM   1769 O O   . ILE   A 1 389 ? 135.573 141.739 142.239 1.00 49.73  ? 251 ILE   R O   1 
ATOM   1770 C CB  . ILE   A 1 389 ? 137.662 142.992 144.529 1.00 32.91  ? 251 ILE   R CB  1 
ATOM   1771 C CG1 . ILE   A 1 389 ? 137.657 143.443 145.987 1.00 40.53  ? 251 ILE   R CG1 1 
ATOM   1772 C CG2 . ILE   A 1 389 ? 137.212 144.131 143.636 1.00 38.34  ? 251 ILE   R CG2 1 
ATOM   1773 C CD1 . ILE   A 1 389 ? 138.579 144.606 146.261 1.00 45.72  ? 251 ILE   R CD1 1 
ATOM   1774 N N   . LEU   A 1 390 ? 137.584 140.728 142.295 1.00 41.50  ? 252 LEU   R N   1 
ATOM   1775 C CA  . LEU   A 1 390 ? 137.540 140.376 140.880 1.00 32.15  ? 252 LEU   R CA  1 
ATOM   1776 C C   . LEU   A 1 390 ? 136.379 139.441 140.571 1.00 33.06  ? 252 LEU   R C   1 
ATOM   1777 O O   . LEU   A 1 390 ? 135.671 139.629 139.576 1.00 37.76  ? 252 LEU   R O   1 
ATOM   1778 C CB  . LEU   A 1 390 ? 138.866 139.739 140.464 1.00 36.77  ? 252 LEU   R CB  1 
ATOM   1779 C CG  . LEU   A 1 390 ? 138.906 138.914 139.176 1.00 40.97  ? 252 LEU   R CG  1 
ATOM   1780 C CD1 . LEU   A 1 390 ? 138.628 139.781 137.964 1.00 37.94  ? 252 LEU   R CD1 1 
ATOM   1781 C CD2 . LEU   A 1 390 ? 140.248 138.218 139.037 1.00 37.62  ? 252 LEU   R CD2 1 
ATOM   1782 N N   . ILE   A 1 391 ? 136.168 138.427 141.410 1.00 40.36  ? 253 ILE   R N   1 
ATOM   1783 C CA  . ILE   A 1 391 ? 135.081 137.484 141.170 1.00 46.65  ? 253 ILE   R CA  1 
ATOM   1784 C C   . ILE   A 1 391 ? 133.731 138.180 141.282 1.00 47.13  ? 253 ILE   R C   1 
ATOM   1785 O O   . ILE   A 1 391 ? 132.830 137.962 140.455 1.00 47.12  ? 253 ILE   R O   1 
ATOM   1786 C CB  . ILE   A 1 391 ? 135.198 136.292 142.136 1.00 44.03  ? 253 ILE   R CB  1 
ATOM   1787 C CG1 . ILE   A 1 391 ? 136.401 135.432 141.753 1.00 44.72  ? 253 ILE   R CG1 1 
ATOM   1788 C CG2 . ILE   A 1 391 ? 133.931 135.462 142.118 1.00 41.52  ? 253 ILE   R CG2 1 
ATOM   1789 C CD1 . ILE   A 1 391 ? 136.831 134.474 142.824 1.00 45.45  ? 253 ILE   R CD1 1 
ATOM   1790 N N   . LEU   A 1 392 ? 133.566 139.033 142.300 1.00 41.14  ? 254 LEU   R N   1 
ATOM   1791 C CA  . LEU   A 1 392 ? 132.302 139.745 142.452 1.00 40.58  ? 254 LEU   R CA  1 
ATOM   1792 C C   . LEU   A 1 392 ? 132.033 140.653 141.258 1.00 44.87  ? 254 LEU   R C   1 
ATOM   1793 O O   . LEU   A 1 392 ? 130.909 140.696 140.746 1.00 51.53  ? 254 LEU   R O   1 
ATOM   1794 C CB  . LEU   A 1 392 ? 132.300 140.551 143.748 1.00 40.69  ? 254 LEU   R CB  1 
ATOM   1795 C CG  . LEU   A 1 392 ? 131.108 141.496 143.906 1.00 44.29  ? 254 LEU   R CG  1 
ATOM   1796 C CD1 . LEU   A 1 392 ? 129.904 140.748 144.446 1.00 42.40  ? 254 LEU   R CD1 1 
ATOM   1797 C CD2 . LEU   A 1 392 ? 131.462 142.669 144.801 1.00 48.08  ? 254 LEU   R CD2 1 
ATOM   1798 N N   . ALA   A 1 393 ? 133.056 141.375 140.791 1.00 40.06  ? 255 ALA   R N   1 
ATOM   1799 C CA  . ALA   A 1 393 ? 132.878 142.249 139.635 1.00 33.41  ? 255 ALA   R CA  1 
ATOM   1800 C C   . ALA   A 1 393 ? 132.540 141.452 138.383 1.00 36.37  ? 255 ALA   R C   1 
ATOM   1801 O O   . ALA   A 1 393 ? 131.674 141.854 137.598 1.00 42.13  ? 255 ALA   R O   1 
ATOM   1802 C CB  . ALA   A 1 393 ? 134.135 143.088 139.413 1.00 37.51  ? 255 ALA   R CB  1 
ATOM   1803 N N   . PHE   A 1 394 ? 133.217 140.319 138.179 1.00 37.34  ? 256 PHE   R N   1 
ATOM   1804 C CA  . PHE   A 1 394 ? 132.947 139.462 137.028 1.00 36.41  ? 256 PHE   R CA  1 
ATOM   1805 C C   . PHE   A 1 394 ? 131.488 139.022 137.004 1.00 39.26  ? 256 PHE   R C   1 
ATOM   1806 O O   . PHE   A 1 394 ? 130.788 139.176 135.990 1.00 45.01  ? 256 PHE   R O   1 
ATOM   1807 C CB  . PHE   A 1 394 ? 133.879 138.251 137.088 1.00 38.69  ? 256 PHE   R CB  1 
ATOM   1808 C CG  . PHE   A 1 394 ? 134.027 137.513 135.791 1.00 41.20  ? 256 PHE   R CG  1 
ATOM   1809 C CD1 . PHE   A 1 394 ? 133.113 136.542 135.421 1.00 34.98  ? 256 PHE   R CD1 1 
ATOM   1810 C CD2 . PHE   A 1 394 ? 135.108 137.756 134.962 1.00 40.79  ? 256 PHE   R CD2 1 
ATOM   1811 C CE1 . PHE   A 1 394 ? 133.257 135.853 134.239 1.00 32.84  ? 256 PHE   R CE1 1 
ATOM   1812 C CE2 . PHE   A 1 394 ? 135.256 137.068 133.779 1.00 40.48  ? 256 PHE   R CE2 1 
ATOM   1813 C CZ  . PHE   A 1 394 ? 134.330 136.116 133.417 1.00 38.06  ? 256 PHE   R CZ  1 
ATOM   1814 N N   . PHE   A 1 395 ? 131.006 138.484 138.124 1.00 34.40  ? 257 PHE   R N   1 
ATOM   1815 C CA  . PHE   A 1 395 ? 129.637 137.985 138.146 1.00 35.71  ? 257 PHE   R CA  1 
ATOM   1816 C C   . PHE   A 1 395 ? 128.620 139.119 138.074 1.00 41.82  ? 257 PHE   R C   1 
ATOM   1817 O O   . PHE   A 1 395 ? 127.560 138.956 137.458 1.00 43.09  ? 257 PHE   R O   1 
ATOM   1818 C CB  . PHE   A 1 395 ? 129.420 137.113 139.379 1.00 39.50  ? 257 PHE   R CB  1 
ATOM   1819 C CG  . PHE   A 1 395 ? 129.941 135.715 139.214 1.00 44.01  ? 257 PHE   R CG  1 
ATOM   1820 C CD1 . PHE   A 1 395 ? 129.178 134.747 138.585 1.00 39.74  ? 257 PHE   R CD1 1 
ATOM   1821 C CD2 . PHE   A 1 395 ? 131.206 135.378 139.657 1.00 42.99  ? 257 PHE   R CD2 1 
ATOM   1822 C CE1 . PHE   A 1 395 ? 129.659 133.465 138.419 1.00 33.46  ? 257 PHE   R CE1 1 
ATOM   1823 C CE2 . PHE   A 1 395 ? 131.693 134.097 139.492 1.00 45.21  ? 257 PHE   R CE2 1 
ATOM   1824 C CZ  . PHE   A 1 395 ? 130.918 133.140 138.872 1.00 38.24  ? 257 PHE   R CZ  1 
ATOM   1825 N N   . ALA   A 1 396 ? 128.927 140.274 138.672 1.00 39.92  ? 258 ALA   R N   1 
ATOM   1826 C CA  . ALA   A 1 396 ? 128.037 141.424 138.561 1.00 35.99  ? 258 ALA   R CA  1 
ATOM   1827 C C   . ALA   A 1 396 ? 127.923 141.895 137.118 1.00 40.79  ? 258 ALA   R C   1 
ATOM   1828 O O   . ALA   A 1 396 ? 126.834 142.262 136.662 1.00 46.13  ? 258 ALA   R O   1 
ATOM   1829 C CB  . ALA   A 1 396 ? 128.531 142.557 139.457 1.00 38.04  ? 258 ALA   R CB  1 
ATOM   1830 N N   . CYS   A 1 397 ? 129.038 141.905 136.385 1.00 39.84  ? 259 CYS   R N   1 
ATOM   1831 C CA  . CYS   A 1 397 ? 128.983 142.260 134.971 1.00 33.66  ? 259 CYS   R CA  1 
ATOM   1832 C C   . CYS   A 1 397 ? 128.137 141.269 134.184 1.00 37.11  ? 259 CYS   R C   1 
ATOM   1833 O O   . CYS   A 1 397 ? 127.298 141.669 133.370 1.00 36.80  ? 259 CYS   R O   1 
ATOM   1834 C CB  . CYS   A 1 397 ? 130.393 142.331 134.382 1.00 28.80  ? 259 CYS   R CB  1 
ATOM   1835 S SG  . CYS   A 1 397 ? 131.390 143.721 134.945 1.00 41.05  ? 259 CYS   R SG  1 
ATOM   1836 N N   . TRP   A 1 398 ? 128.335 139.970 134.418 1.00 36.17  ? 260 TRP   R N   1 
ATOM   1837 C CA  . TRP   A 1 398 ? 127.697 138.983 133.552 1.00 30.65  ? 260 TRP   R CA  1 
ATOM   1838 C C   . TRP   A 1 398 ? 126.235 138.706 133.893 1.00 33.18  ? 260 TRP   R C   1 
ATOM   1839 O O   . TRP   A 1 398 ? 125.504 138.227 133.022 1.00 39.64  ? 260 TRP   R O   1 
ATOM   1840 C CB  . TRP   A 1 398 ? 128.475 137.668 133.584 1.00 28.02  ? 260 TRP   R CB  1 
ATOM   1841 C CG  . TRP   A 1 398 ? 129.524 137.561 132.521 1.00 27.92  ? 260 TRP   R CG  1 
ATOM   1842 C CD1 . TRP   A 1 398 ? 130.867 137.685 132.688 1.00 33.34  ? 260 TRP   R CD1 1 
ATOM   1843 C CD2 . TRP   A 1 398 ? 129.315 137.302 131.128 1.00 32.95  ? 260 TRP   R CD2 1 
ATOM   1844 N NE1 . TRP   A 1 398 ? 131.512 137.521 131.488 1.00 40.26  ? 260 TRP   R NE1 1 
ATOM   1845 C CE2 . TRP   A 1 398 ? 130.581 137.284 130.514 1.00 39.30  ? 260 TRP   R CE2 1 
ATOM   1846 C CE3 . TRP   A 1 398 ? 128.182 137.084 130.340 1.00 34.27  ? 260 TRP   R CE3 1 
ATOM   1847 C CZ2 . TRP   A 1 398 ? 130.746 137.058 129.150 1.00 40.05  ? 260 TRP   R CZ2 1 
ATOM   1848 C CZ3 . TRP   A 1 398 ? 128.350 136.860 128.985 1.00 32.68  ? 260 TRP   R CZ3 1 
ATOM   1849 C CH2 . TRP   A 1 398 ? 129.620 136.850 128.405 1.00 34.38  ? 260 TRP   R CH2 1 
ATOM   1850 N N   . LEU   A 1 399 ? 125.787 138.993 135.119 1.00 31.56  ? 261 LEU   R N   1 
ATOM   1851 C CA  . LEU   A 1 399 ? 124.467 138.526 135.546 1.00 36.33  ? 261 LEU   R CA  1 
ATOM   1852 C C   . LEU   A 1 399 ? 123.299 139.058 134.719 1.00 41.94  ? 261 LEU   R C   1 
ATOM   1853 O O   . LEU   A 1 399 ? 122.429 138.252 134.340 1.00 50.24  ? 261 LEU   R O   1 
ATOM   1854 C CB  . LEU   A 1 399 ? 124.265 138.848 137.029 1.00 33.39  ? 261 LEU   R CB  1 
ATOM   1855 C CG  . LEU   A 1 399 ? 122.956 138.297 137.599 1.00 30.25  ? 261 LEU   R CG  1 
ATOM   1856 C CD1 . LEU   A 1 399 ? 123.099 136.818 137.913 1.00 33.11  ? 261 LEU   R CD1 1 
ATOM   1857 C CD2 . LEU   A 1 399 ? 122.520 139.079 138.826 1.00 37.74  ? 261 LEU   R CD2 1 
ATOM   1858 N N   . PRO   A 1 400 ? 123.175 140.363 134.439 1.00 30.39  ? 262 PRO   R N   1 
ATOM   1859 C CA  . PRO   A 1 400 ? 121.987 140.824 133.697 1.00 33.03  ? 262 PRO   R CA  1 
ATOM   1860 C C   . PRO   A 1 400 ? 121.857 140.210 132.313 1.00 37.59  ? 262 PRO   R C   1 
ATOM   1861 O O   . PRO   A 1 400 ? 120.733 139.974 131.851 1.00 44.07  ? 262 PRO   R O   1 
ATOM   1862 C CB  . PRO   A 1 400 ? 122.180 142.345 133.633 1.00 34.17  ? 262 PRO   R CB  1 
ATOM   1863 C CG  . PRO   A 1 400 ? 123.146 142.661 134.713 1.00 33.63  ? 262 PRO   R CG  1 
ATOM   1864 C CD  . PRO   A 1 400 ? 124.060 141.488 134.783 1.00 30.50  ? 262 PRO   R CD  1 
ATOM   1865 N N   . TYR   A 1 401 ? 122.973 139.931 131.639 1.00 36.99  ? 263 TYR   R N   1 
ATOM   1866 C CA  . TYR   A 1 401 ? 122.903 139.231 130.362 1.00 26.72  ? 263 TYR   R CA  1 
ATOM   1867 C C   . TYR   A 1 401 ? 122.335 137.831 130.537 1.00 37.03  ? 263 TYR   R C   1 
ATOM   1868 O O   . TYR   A 1 401 ? 121.558 137.357 129.700 1.00 41.72  ? 263 TYR   R O   1 
ATOM   1869 C CB  . TYR   A 1 401 ? 124.286 139.168 129.721 1.00 30.07  ? 263 TYR   R CB  1 
ATOM   1870 C CG  . TYR   A 1 401 ? 124.336 138.313 128.481 1.00 32.14  ? 263 TYR   R CG  1 
ATOM   1871 C CD1 . TYR   A 1 401 ? 123.634 138.672 127.342 1.00 43.37  ? 263 TYR   R CD1 1 
ATOM   1872 C CD2 . TYR   A 1 401 ? 125.084 137.148 128.448 1.00 28.60  ? 263 TYR   R CD2 1 
ATOM   1873 C CE1 . TYR   A 1 401 ? 123.678 137.897 126.203 1.00 43.90  ? 263 TYR   R CE1 1 
ATOM   1874 C CE2 . TYR   A 1 401 ? 125.134 136.365 127.316 1.00 33.73  ? 263 TYR   R CE2 1 
ATOM   1875 C CZ  . TYR   A 1 401 ? 124.428 136.743 126.196 1.00 40.04  ? 263 TYR   R CZ  1 
ATOM   1876 O OH  . TYR   A 1 401 ? 124.472 135.968 125.062 1.00 39.57  ? 263 TYR   R OH  1 
ATOM   1877 N N   . TYR   A 1 402 ? 122.726 137.147 131.614 1.00 40.24  ? 264 TYR   R N   1 
ATOM   1878 C CA  . TYR   A 1 402 ? 122.187 135.819 131.883 1.00 30.73  ? 264 TYR   R CA  1 
ATOM   1879 C C   . TYR   A 1 402 ? 120.693 135.880 132.165 1.00 35.36  ? 264 TYR   R C   1 
ATOM   1880 O O   . TYR   A 1 402 ? 119.935 135.013 131.717 1.00 39.31  ? 264 TYR   R O   1 
ATOM   1881 C CB  . TYR   A 1 402 ? 122.941 135.177 133.044 1.00 22.22  ? 264 TYR   R CB  1 
ATOM   1882 C CG  . TYR   A 1 402 ? 124.309 134.670 132.654 1.00 30.48  ? 264 TYR   R CG  1 
ATOM   1883 C CD1 . TYR   A 1 402 ? 124.480 133.886 131.524 1.00 34.20  ? 264 TYR   R CD1 1 
ATOM   1884 C CD2 . TYR   A 1 402 ? 125.429 134.979 133.408 1.00 33.65  ? 264 TYR   R CD2 1 
ATOM   1885 C CE1 . TYR   A 1 402 ? 125.723 133.422 131.157 1.00 30.24  ? 264 TYR   R CE1 1 
ATOM   1886 C CE2 . TYR   A 1 402 ? 126.679 134.517 133.049 1.00 36.59  ? 264 TYR   R CE2 1 
ATOM   1887 C CZ  . TYR   A 1 402 ? 126.819 133.739 131.922 1.00 37.12  ? 264 TYR   R CZ  1 
ATOM   1888 O OH  . TYR   A 1 402 ? 128.061 133.275 131.557 1.00 36.75  ? 264 TYR   R OH  1 
ATOM   1889 N N   . ILE   A 1 403 ? 120.247 136.907 132.891 1.00 32.51  ? 265 ILE   R N   1 
ATOM   1890 C CA  . ILE   A 1 403 ? 118.814 137.089 133.115 1.00 33.80  ? 265 ILE   R CA  1 
ATOM   1891 C C   . ILE   A 1 403 ? 118.093 137.295 131.788 1.00 33.42  ? 265 ILE   R C   1 
ATOM   1892 O O   . ILE   A 1 403 ? 117.031 136.710 131.534 1.00 40.01  ? 265 ILE   R O   1 
ATOM   1893 C CB  . ILE   A 1 403 ? 118.563 138.263 134.078 1.00 30.80  ? 265 ILE   R CB  1 
ATOM   1894 C CG1 . ILE   A 1 403 ? 119.235 138.006 135.426 1.00 37.45  ? 265 ILE   R CG1 1 
ATOM   1895 C CG2 . ILE   A 1 403 ? 117.077 138.495 134.260 1.00 38.31  ? 265 ILE   R CG2 1 
ATOM   1896 C CD1 . ILE   A 1 403 ? 119.323 139.232 136.300 1.00 37.52  ? 265 ILE   R CD1 1 
ATOM   1897 N N   . GLY   A 1 404 ? 118.664 138.131 130.921 1.00 31.14  ? 266 GLY   R N   1 
ATOM   1898 C CA  . GLY   A 1 404 ? 118.035 138.388 129.637 1.00 33.94  ? 266 GLY   R CA  1 
ATOM   1899 C C   . GLY   A 1 404 ? 117.930 137.146 128.773 1.00 43.44  ? 266 GLY   R C   1 
ATOM   1900 O O   . GLY   A 1 404 ? 116.882 136.880 128.181 1.00 51.35  ? 266 GLY   R O   1 
ATOM   1901 N N   . ILE   A 1 405 ? 119.009 136.364 128.694 1.00 47.04  ? 267 ILE   R N   1 
ATOM   1902 C CA  . ILE   A 1 405 ? 118.960 135.165 127.861 1.00 40.87  ? 267 ILE   R CA  1 
ATOM   1903 C C   . ILE   A 1 405 ? 118.056 134.109 128.479 1.00 46.14  ? 267 ILE   R C   1 
ATOM   1904 O O   . ILE   A 1 405 ? 117.433 133.328 127.755 1.00 50.90  ? 267 ILE   R O   1 
ATOM   1905 C CB  . ILE   A 1 405 ? 120.368 134.608 127.583 1.00 39.75  ? 267 ILE   R CB  1 
ATOM   1906 C CG1 . ILE   A 1 405 ? 121.066 134.183 128.871 1.00 37.99  ? 267 ILE   R CG1 1 
ATOM   1907 C CG2 . ILE   A 1 405 ? 121.193 135.619 126.827 1.00 45.15  ? 267 ILE   R CG2 1 
ATOM   1908 C CD1 . ILE   A 1 405 ? 122.443 133.605 128.642 1.00 39.87  ? 267 ILE   R CD1 1 
ATOM   1909 N N   . SER   A 1 406 ? 117.958 134.055 129.810 1.00 47.83  ? 268 SER   R N   1 
ATOM   1910 C CA  . SER   A 1 406 ? 117.004 133.144 130.434 1.00 45.07  ? 268 SER   R CA  1 
ATOM   1911 C C   . SER   A 1 406 ? 115.574 133.513 130.062 1.00 48.33  ? 268 SER   R C   1 
ATOM   1912 O O   . SER   A 1 406 ? 114.765 132.641 129.717 1.00 49.60  ? 268 SER   R O   1 
ATOM   1913 C CB  . SER   A 1 406 ? 117.184 133.159 131.949 1.00 41.87  ? 268 SER   R CB  1 
ATOM   1914 O OG  . SER   A 1 406 ? 118.558 133.150 132.294 1.00 44.86  ? 268 SER   R OG  1 
ATOM   1915 N N   . ILE   A 1 407 ? 115.250 134.807 130.110 1.00 59.34  ? 269 ILE   R N   1 
ATOM   1916 C CA  . ILE   A 1 407 ? 113.913 135.248 129.718 1.00 57.32  ? 269 ILE   R CA  1 
ATOM   1917 C C   . ILE   A 1 407 ? 113.663 134.939 128.246 1.00 63.85  ? 269 ILE   R C   1 
ATOM   1918 O O   . ILE   A 1 407 ? 112.571 134.501 127.866 1.00 68.35  ? 269 ILE   R O   1 
ATOM   1919 C CB  . ILE   A 1 407 ? 113.728 136.745 130.023 1.00 56.21  ? 269 ILE   R CB  1 
ATOM   1920 C CG1 . ILE   A 1 407 ? 113.832 137.002 131.525 1.00 54.95  ? 269 ILE   R CG1 1 
ATOM   1921 C CG2 . ILE   A 1 407 ? 112.383 137.228 129.510 1.00 59.63  ? 269 ILE   R CG2 1 
ATOM   1922 C CD1 . ILE   A 1 407 ? 114.116 138.444 131.871 1.00 54.26  ? 269 ILE   R CD1 1 
ATOM   1923 N N   . ASP   A 1 408 ? 114.670 135.158 127.396 1.00 64.94  ? 270 ASP   R N   1 
ATOM   1924 C CA  . ASP   A 1 408 ? 114.521 134.853 125.975 1.00 61.40  ? 270 ASP   R CA  1 
ATOM   1925 C C   . ASP   A 1 408 ? 114.280 133.366 125.748 1.00 62.05  ? 270 ASP   R C   1 
ATOM   1926 O O   . ASP   A 1 408 ? 113.424 132.982 124.941 1.00 62.22  ? 270 ASP   R O   1 
ATOM   1927 C CB  . ASP   A 1 408 ? 115.761 135.310 125.211 1.00 62.25  ? 270 ASP   R CB  1 
ATOM   1928 C CG  . ASP   A 1 408 ? 115.503 135.483 123.728 1.00 70.31  ? 270 ASP   R CG  1 
ATOM   1929 O OD1 . ASP   A 1 408 ? 114.328 135.410 123.315 1.00 70.87  ? 270 ASP   R OD1 1 
ATOM   1930 O OD2 . ASP   A 1 408 ? 116.477 135.691 122.974 1.00 70.76  ? 270 ASP   R OD2 1 
ATOM   1931 N N   . SER   A 1 409 ? 115.028 132.513 126.450 1.00 59.52  ? 271 SER   R N   1 
ATOM   1932 C CA  . SER   A 1 409 ? 114.843 131.075 126.310 1.00 59.50  ? 271 SER   R CA  1 
ATOM   1933 C C   . SER   A 1 409 ? 113.444 130.663 126.740 1.00 61.13  ? 271 SER   R C   1 
ATOM   1934 O O   . SER   A 1 409 ? 112.800 129.843 126.078 1.00 63.78  ? 271 SER   R O   1 
ATOM   1935 C CB  . SER   A 1 409 ? 115.898 130.328 127.125 1.00 62.18  ? 271 SER   R CB  1 
ATOM   1936 O OG  . SER   A 1 409 ? 117.206 130.712 126.741 1.00 66.11  ? 271 SER   R OG  1 
ATOM   1937 N N   . PHE   A 1 410 ? 112.952 131.228 127.845 1.00 63.49  ? 272 PHE   R N   1 
ATOM   1938 C CA  . PHE   A 1 410 ? 111.598 130.897 128.274 1.00 63.26  ? 272 PHE   R CA  1 
ATOM   1939 C C   . PHE   A 1 410 ? 110.557 131.423 127.294 1.00 64.42  ? 272 PHE   R C   1 
ATOM   1940 O O   . PHE   A 1 410 ? 109.484 130.827 127.153 1.00 65.54  ? 272 PHE   R O   1 
ATOM   1941 C CB  . PHE   A 1 410 ? 111.342 131.430 129.682 1.00 63.30  ? 272 PHE   R CB  1 
ATOM   1942 C CG  . PHE   A 1 410 ? 111.996 130.612 130.756 1.00 65.50  ? 272 PHE   R CG  1 
ATOM   1943 C CD1 . PHE   A 1 410 ? 111.693 129.273 130.901 1.00 63.31  ? 272 PHE   R CD1 1 
ATOM   1944 C CD2 . PHE   A 1 410 ? 112.920 131.180 131.614 1.00 68.59  ? 272 PHE   R CD2 1 
ATOM   1945 C CE1 . PHE   A 1 410 ? 112.296 128.514 131.881 1.00 65.49  ? 272 PHE   R CE1 1 
ATOM   1946 C CE2 . PHE   A 1 410 ? 113.527 130.427 132.597 1.00 67.42  ? 272 PHE   R CE2 1 
ATOM   1947 C CZ  . PHE   A 1 410 ? 113.214 129.093 132.731 1.00 66.81  ? 272 PHE   R CZ  1 
ATOM   1948 N N   . ILE   A 1 411 ? 110.852 132.533 126.614 1.00 72.16  ? 273 ILE   R N   1 
ATOM   1949 C CA  . ILE   A 1 411 ? 109.989 132.990 125.526 1.00 72.45  ? 273 ILE   R CA  1 
ATOM   1950 C C   . ILE   A 1 411 ? 109.956 131.954 124.412 1.00 74.01  ? 273 ILE   R C   1 
ATOM   1951 O O   . ILE   A 1 411 ? 108.890 131.624 123.877 1.00 75.81  ? 273 ILE   R O   1 
ATOM   1952 C CB  . ILE   A 1 411 ? 110.460 134.361 125.003 1.00 71.04  ? 273 ILE   R CB  1 
ATOM   1953 C CG1 . ILE   A 1 411 ? 110.163 135.464 126.017 1.00 71.90  ? 273 ILE   R CG1 1 
ATOM   1954 C CG2 . ILE   A 1 411 ? 109.806 134.678 123.668 1.00 71.52  ? 273 ILE   R CG2 1 
ATOM   1955 C CD1 . ILE   A 1 411 ? 111.082 136.652 125.895 1.00 68.75  ? 273 ILE   R CD1 1 
ATOM   1956 N N   . LEU   A 1 412 ? 111.127 131.426 124.044 1.00 80.48  ? 274 LEU   R N   1 
ATOM   1957 C CA  . LEU   A 1 412 ? 111.186 130.393 123.014 1.00 80.81  ? 274 LEU   R CA  1 
ATOM   1958 C C   . LEU   A 1 412 ? 110.487 129.118 123.467 1.00 79.24  ? 274 LEU   R C   1 
ATOM   1959 O O   . LEU   A 1 412 ? 109.836 128.441 122.663 1.00 79.23  ? 274 LEU   R O   1 
ATOM   1960 C CB  . LEU   A 1 412 ? 112.640 130.105 122.642 1.00 80.05  ? 274 LEU   R CB  1 
ATOM   1961 C CG  . LEU   A 1 412 ? 113.303 131.125 121.717 1.00 79.70  ? 274 LEU   R CG  1 
ATOM   1962 C CD1 . LEU   A 1 412 ? 114.789 130.838 121.574 1.00 78.43  ? 274 LEU   R CD1 1 
ATOM   1963 C CD2 . LEU   A 1 412 ? 112.618 131.125 120.362 1.00 76.83  ? 274 LEU   R CD2 1 
ATOM   1964 N N   . LEU   A 1 413 ? 110.605 128.776 124.747 1.00 72.08  ? 275 LEU   R N   1 
ATOM   1965 C CA  . LEU   A 1 413 ? 109.976 127.583 125.297 1.00 72.55  ? 275 LEU   R CA  1 
ATOM   1966 C C   . LEU   A 1 413 ? 108.485 127.764 125.561 1.00 75.60  ? 275 LEU   R C   1 
ATOM   1967 O O   . LEU   A 1 413 ? 107.892 126.932 126.255 1.00 76.89  ? 275 LEU   R O   1 
ATOM   1968 C CB  . LEU   A 1 413 ? 110.687 127.166 126.587 1.00 71.13  ? 275 LEU   R CB  1 
ATOM   1969 C CG  . LEU   A 1 413 ? 112.127 126.682 126.416 1.00 70.29  ? 275 LEU   R CG  1 
ATOM   1970 C CD1 . LEU   A 1 413 ? 112.772 126.416 127.766 1.00 71.31  ? 275 LEU   R CD1 1 
ATOM   1971 C CD2 . LEU   A 1 413 ? 112.168 125.440 125.544 1.00 74.81  ? 275 LEU   R CD2 1 
ATOM   1972 N N   . GLU   A 1 414 ? 107.881 128.832 125.041 1.00 81.72  ? 276 GLU   R N   1 
ATOM   1973 C CA  . GLU   A 1 414 ? 106.449 129.109 125.115 1.00 81.10  ? 276 GLU   R CA  1 
ATOM   1974 C C   . GLU   A 1 414 ? 105.957 129.364 126.535 1.00 81.11  ? 276 GLU   R C   1 
ATOM   1975 O O   . GLU   A 1 414 ? 104.745 129.468 126.754 1.00 83.07  ? 276 GLU   R O   1 
ATOM   1976 C CB  . GLU   A 1 414 ? 105.624 127.981 124.478 1.00 81.92  ? 276 GLU   R CB  1 
ATOM   1977 C CG  . GLU   A 1 414 ? 105.921 127.745 123.005 1.00 83.90  ? 276 GLU   R CG  1 
ATOM   1978 C CD  . GLU   A 1 414 ? 104.738 127.154 122.261 1.00 85.24  ? 276 GLU   R CD  1 
ATOM   1979 O OE1 . GLU   A 1 414 ? 103.626 127.139 122.828 1.00 85.27  ? 276 GLU   R OE1 1 
ATOM   1980 O OE2 . GLU   A 1 414 ? 104.921 126.704 121.109 1.00 82.98  ? 276 GLU   R OE2 1 
ATOM   1981 N N   . ILE   A 1 415 ? 106.859 129.467 127.511 1.00 75.64  ? 277 ILE   R N   1 
ATOM   1982 C CA  . ILE   A 1 415 ? 106.435 129.749 128.879 1.00 77.32  ? 277 ILE   R CA  1 
ATOM   1983 C C   . ILE   A 1 415 ? 105.948 131.189 129.003 1.00 79.80  ? 277 ILE   R C   1 
ATOM   1984 O O   . ILE   A 1 415 ? 104.907 131.458 129.615 1.00 78.54  ? 277 ILE   R O   1 
ATOM   1985 C CB  . ILE   A 1 415 ? 107.573 129.439 129.868 1.00 79.53  ? 277 ILE   R CB  1 
ATOM   1986 C CG1 . ILE   A 1 415 ? 107.685 127.927 130.077 1.00 77.98  ? 277 ILE   R CG1 1 
ATOM   1987 C CG2 . ILE   A 1 415 ? 107.350 130.150 131.194 1.00 78.67  ? 277 ILE   R CG2 1 
ATOM   1988 C CD1 . ILE   A 1 415 ? 108.729 127.518 131.087 1.00 78.98  ? 277 ILE   R CD1 1 
ATOM   1989 N N   . ILE   A 1 416 ? 106.678 132.130 128.413 1.00 76.44  ? 278 ILE   R N   1 
ATOM   1990 C CA  . ILE   A 1 416 ? 106.342 133.548 128.476 1.00 71.67  ? 278 ILE   R CA  1 
ATOM   1991 C C   . ILE   A 1 416 ? 105.632 133.922 127.181 1.00 69.77  ? 278 ILE   R C   1 
ATOM   1992 O O   . ILE   A 1 416 ? 106.243 133.933 126.108 1.00 69.86  ? 278 ILE   R O   1 
ATOM   1993 C CB  . ILE   A 1 416 ? 107.587 134.416 128.696 1.00 69.65  ? 278 ILE   R CB  1 
ATOM   1994 C CG1 . ILE   A 1 416 ? 108.224 134.108 130.053 1.00 71.60  ? 278 ILE   R CG1 1 
ATOM   1995 C CG2 . ILE   A 1 416 ? 107.229 135.885 128.598 1.00 68.67  ? 278 ILE   R CG2 1 
ATOM   1996 C CD1 . ILE   A 1 416 ? 109.503 134.877 130.315 1.00 69.03  ? 278 ILE   R CD1 1 
ATOM   1997 N N   . LYS   A 1 417 ? 104.345 134.245 127.281 1.00 76.73  ? 279 LYS   R N   1 
ATOM   1998 C CA  . LYS   A 1 417 ? 103.515 134.583 126.129 1.00 79.33  ? 279 LYS   R CA  1 
ATOM   1999 C C   . LYS   A 1 417 ? 103.053 136.028 126.261 1.00 79.31  ? 279 LYS   R C   1 
ATOM   2000 O O   . LYS   A 1 417 ? 102.267 136.355 127.156 1.00 77.99  ? 279 LYS   R O   1 
ATOM   2001 C CB  . LYS   A 1 417 ? 102.319 133.640 126.025 1.00 80.35  ? 279 LYS   R CB  1 
ATOM   2002 C CG  . LYS   A 1 417 ? 102.673 132.206 125.673 1.00 79.73  ? 279 LYS   R CG  1 
ATOM   2003 C CD  . LYS   A 1 417 ? 103.070 132.082 124.213 1.00 79.59  ? 279 LYS   R CD  1 
ATOM   2004 C CE  . LYS   A 1 417 ? 103.305 130.634 123.829 1.00 78.17  ? 279 LYS   R CE  1 
ATOM   2005 N NZ  . LYS   A 1 417 ? 103.776 130.503 122.424 1.00 80.70  ? 279 LYS   R NZ  1 
ATOM   2006 N N   . GLN   A 1 418 ? 103.536 136.888 125.366 1.00 82.92  ? 280 GLN   R N   1 
ATOM   2007 C CA  . GLN   A 1 418 ? 103.132 138.289 125.317 1.00 84.20  ? 280 GLN   R CA  1 
ATOM   2008 C C   . GLN   A 1 418 ? 103.097 138.720 123.852 1.00 83.27  ? 280 GLN   R C   1 
ATOM   2009 O O   . GLN   A 1 418 ? 103.159 137.892 122.938 1.00 79.42  ? 280 GLN   R O   1 
ATOM   2010 C CB  . GLN   A 1 418 ? 104.072 139.171 126.153 1.00 83.56  ? 280 GLN   R CB  1 
ATOM   2011 C CG  . GLN   A 1 418 ? 104.104 138.851 127.641 1.00 81.08  ? 280 GLN   R CG  1 
ATOM   2012 C CD  . GLN   A 1 418 ? 103.008 139.553 128.416 1.00 82.33  ? 280 GLN   R CD  1 
ATOM   2013 O OE1 . GLN   A 1 418 ? 102.151 140.219 127.837 1.00 85.76  ? 280 GLN   R OE1 1 
ATOM   2014 N NE2 . GLN   A 1 418 ? 103.027 139.401 129.735 1.00 81.16  ? 280 GLN   R NE2 1 
ATOM   2015 N N   . GLY   A 1 419 ? 102.996 140.032 123.628 1.00 87.58  ? 281 GLY   R N   1 
ATOM   2016 C CA  . GLY   A 1 419 ? 102.967 140.561 122.282 1.00 86.46  ? 281 GLY   R CA  1 
ATOM   2017 C C   . GLY   A 1 419 ? 104.351 140.737 121.685 1.00 86.28  ? 281 GLY   R C   1 
ATOM   2018 O O   . GLY   A 1 419 ? 105.374 140.514 122.330 1.00 88.37  ? 281 GLY   R O   1 
ATOM   2019 N N   . CYS   A 1 420 ? 104.368 141.158 120.416 1.00 91.74  ? 282 CYS   R N   1 
ATOM   2020 C CA  . CYS   A 1 420 ? 105.630 141.325 119.702 1.00 94.33  ? 282 CYS   R CA  1 
ATOM   2021 C C   . CYS   A 1 420 ? 106.487 142.425 120.314 1.00 93.71  ? 282 CYS   R C   1 
ATOM   2022 O O   . CYS   A 1 420 ? 107.722 142.356 120.257 1.00 92.34  ? 282 CYS   R O   1 
ATOM   2023 C CB  . CYS   A 1 420 ? 105.362 141.624 118.227 1.00 95.20  ? 282 CYS   R CB  1 
ATOM   2024 S SG  . CYS   A 1 420 ? 104.358 140.381 117.381 1.00 102.99 ? 282 CYS   R SG  1 
ATOM   2025 N N   . GLU   A 1 421 ? 105.854 143.450 120.890 1.00 94.01  ? 283 GLU   R N   1 
ATOM   2026 C CA  . GLU   A 1 421 ? 106.611 144.512 121.545 1.00 94.36  ? 283 GLU   R CA  1 
ATOM   2027 C C   . GLU   A 1 421 ? 107.430 143.961 122.704 1.00 92.43  ? 283 GLU   R C   1 
ATOM   2028 O O   . GLU   A 1 421 ? 108.551 144.416 122.954 1.00 90.45  ? 283 GLU   R O   1 
ATOM   2029 C CB  . GLU   A 1 421 ? 105.662 145.611 122.025 1.00 94.31  ? 283 GLU   R CB  1 
ATOM   2030 C CG  . GLU   A 1 421 ? 106.349 146.787 122.702 1.00 95.21  ? 283 GLU   R CG  1 
ATOM   2031 C CD  . GLU   A 1 421 ? 105.380 147.654 123.480 1.00 95.73  ? 283 GLU   R CD  1 
ATOM   2032 O OE1 . GLU   A 1 421 ? 104.163 147.374 123.433 1.00 94.91  ? 283 GLU   R OE1 1 
ATOM   2033 O OE2 . GLU   A 1 421 ? 105.832 148.616 124.136 1.00 96.37  ? 283 GLU   R OE2 1 
ATOM   2034 N N   . PHE   A 1 422 ? 106.888 142.971 123.415 1.00 78.88  ? 284 PHE   R N   1 
ATOM   2035 C CA  . PHE   A 1 422 ? 107.635 142.313 124.481 1.00 76.58  ? 284 PHE   R CA  1 
ATOM   2036 C C   . PHE   A 1 422 ? 108.903 141.666 123.936 1.00 76.90  ? 284 PHE   R C   1 
ATOM   2037 O O   . PHE   A 1 422 ? 109.991 141.822 124.507 1.00 75.01  ? 284 PHE   R O   1 
ATOM   2038 C CB  . PHE   A 1 422 ? 106.738 141.274 125.158 1.00 73.68  ? 284 PHE   R CB  1 
ATOM   2039 C CG  . PHE   A 1 422 ? 107.305 140.695 126.423 1.00 69.68  ? 284 PHE   R CG  1 
ATOM   2040 C CD1 . PHE   A 1 422 ? 108.308 139.743 126.383 1.00 71.49  ? 284 PHE   R CD1 1 
ATOM   2041 C CD2 . PHE   A 1 422 ? 106.812 141.084 127.653 1.00 72.99  ? 284 PHE   R CD2 1 
ATOM   2042 C CE1 . PHE   A 1 422 ? 108.821 139.209 127.543 1.00 73.08  ? 284 PHE   R CE1 1 
ATOM   2043 C CE2 . PHE   A 1 422 ? 107.321 140.550 128.818 1.00 75.22  ? 284 PHE   R CE2 1 
ATOM   2044 C CZ  . PHE   A 1 422 ? 108.327 139.611 128.762 1.00 74.13  ? 284 PHE   R CZ  1 
ATOM   2045 N N   . GLU   A 1 423 ? 108.776 140.929 122.828 1.00 87.40  ? 285 GLU   R N   1 
ATOM   2046 C CA  . GLU   A 1 423 ? 109.934 140.265 122.239 1.00 88.90  ? 285 GLU   R CA  1 
ATOM   2047 C C   . GLU   A 1 423 ? 110.966 141.279 121.764 1.00 89.10  ? 285 GLU   R C   1 
ATOM   2048 O O   . GLU   A 1 423 ? 112.171 141.098 121.978 1.00 88.05  ? 285 GLU   R O   1 
ATOM   2049 C CB  . GLU   A 1 423 ? 109.498 139.358 121.088 1.00 87.71  ? 285 GLU   R CB  1 
ATOM   2050 C CG  . GLU   A 1 423 ? 109.187 137.930 121.513 1.00 87.57  ? 285 GLU   R CG  1 
ATOM   2051 C CD  . GLU   A 1 423 ? 107.701 137.679 121.679 1.00 90.90  ? 285 GLU   R CD  1 
ATOM   2052 O OE1 . GLU   A 1 423 ? 106.901 138.510 121.204 1.00 91.61  ? 285 GLU   R OE1 1 
ATOM   2053 O OE2 . GLU   A 1 423 ? 107.330 136.654 122.290 1.00 90.76  ? 285 GLU   R OE2 1 
ATOM   2054 N N   . ASN   A 1 424 ? 110.512 142.360 121.128 1.00 85.95  ? 286 ASN   R N   1 
ATOM   2055 C CA  . ASN   A 1 424 ? 111.445 143.402 120.712 1.00 85.38  ? 286 ASN   R CA  1 
ATOM   2056 C C   . ASN   A 1 424 ? 112.162 144.000 121.914 1.00 82.13  ? 286 ASN   R C   1 
ATOM   2057 O O   . ASN   A 1 424 ? 113.381 144.212 121.878 1.00 81.86  ? 286 ASN   R O   1 
ATOM   2058 C CB  . ASN   A 1 424 ? 110.706 144.488 119.931 1.00 83.77  ? 286 ASN   R CB  1 
ATOM   2059 C CG  . ASN   A 1 424 ? 110.337 144.050 118.529 1.00 83.70  ? 286 ASN   R CG  1 
ATOM   2060 O OD1 . ASN   A 1 424 ? 111.026 143.232 117.923 1.00 82.76  ? 286 ASN   R OD1 1 
ATOM   2061 N ND2 . ASN   A 1 424 ? 109.246 144.595 118.006 1.00 84.22  ? 286 ASN   R ND2 1 
ATOM   2062 N N   . THR   A 1 425 ? 111.422 144.265 122.993 1.00 75.73  ? 287 THR   R N   1 
ATOM   2063 C CA  . THR   A 1 425 ? 112.021 144.873 124.173 1.00 78.27  ? 287 THR   R CA  1 
ATOM   2064 C C   . THR   A 1 425 ? 113.088 143.974 124.776 1.00 79.04  ? 287 THR   R C   1 
ATOM   2065 O O   . THR   A 1 425 ? 114.183 144.442 125.113 1.00 81.25  ? 287 THR   R O   1 
ATOM   2066 C CB  . THR   A 1 425 ? 110.941 145.185 125.208 1.00 77.85  ? 287 THR   R CB  1 
ATOM   2067 O OG1 . THR   A 1 425 ? 109.875 145.912 124.586 1.00 78.06  ? 287 THR   R OG1 1 
ATOM   2068 C CG2 . THR   A 1 425 ? 111.520 146.013 126.345 1.00 76.52  ? 287 THR   R CG2 1 
ATOM   2069 N N   . VAL   A 1 426 ? 112.800 142.676 124.908 1.00 67.96  ? 288 VAL   R N   1 
ATOM   2070 C CA  . VAL   A 1 426 ? 113.794 141.785 125.505 1.00 67.03  ? 288 VAL   R CA  1 
ATOM   2071 C C   . VAL   A 1 426 ? 114.978 141.612 124.560 1.00 68.20  ? 288 VAL   R C   1 
ATOM   2072 O O   . VAL   A 1 426 ? 116.122 141.451 125.000 1.00 70.37  ? 288 VAL   R O   1 
ATOM   2073 C CB  . VAL   A 1 426 ? 113.168 140.432 125.900 1.00 66.55  ? 288 VAL   R CB  1 
ATOM   2074 C CG1 . VAL   A 1 426 ? 112.321 139.883 124.793 1.00 70.22  ? 288 VAL   R CG1 1 
ATOM   2075 C CG2 . VAL   A 1 426 ? 114.236 139.433 126.318 1.00 64.21  ? 288 VAL   R CG2 1 
ATOM   2076 N N   . HIS   A 1 427 ? 114.734 141.678 123.248 1.00 61.27  ? 289 HIS   R N   1 
ATOM   2077 C CA  . HIS   A 1 427 ? 115.829 141.593 122.285 1.00 61.39  ? 289 HIS   R CA  1 
ATOM   2078 C C   . HIS   A 1 427 ? 116.802 142.760 122.444 1.00 68.23  ? 289 HIS   R C   1 
ATOM   2079 O O   . HIS   A 1 427 ? 118.023 142.561 122.531 1.00 67.75  ? 289 HIS   R O   1 
ATOM   2080 C CB  . HIS   A 1 427 ? 115.257 141.548 120.868 1.00 61.64  ? 289 HIS   R CB  1 
ATOM   2081 C CG  . HIS   A 1 427 ? 116.260 141.193 119.817 1.00 66.35  ? 289 HIS   R CG  1 
ATOM   2082 N ND1 . HIS   A 1 427 ? 116.558 139.890 119.482 1.00 67.65  ? 289 HIS   R ND1 1 
ATOM   2083 C CD2 . HIS   A 1 427 ? 117.027 141.971 119.017 1.00 67.95  ? 289 HIS   R CD2 1 
ATOM   2084 C CE1 . HIS   A 1 427 ? 117.468 139.881 118.524 1.00 67.27  ? 289 HIS   R CE1 1 
ATOM   2085 N NE2 . HIS   A 1 427 ? 117.771 141.131 118.225 1.00 68.63  ? 289 HIS   R NE2 1 
ATOM   2086 N N   . LYS   A 1 428 ? 116.282 143.992 122.483 1.00 60.65  ? 290 LYS   R N   1 
ATOM   2087 C CA  . LYS   A 1 428 ? 117.163 145.142 122.690 1.00 53.31  ? 290 LYS   R CA  1 
ATOM   2088 C C   . LYS   A 1 428 ? 117.830 145.090 124.058 1.00 54.39  ? 290 LYS   R C   1 
ATOM   2089 O O   . LYS   A 1 428 ? 119.006 145.455 124.199 1.00 57.07  ? 290 LYS   R O   1 
ATOM   2090 C CB  . LYS   A 1 428 ? 116.409 146.462 122.522 1.00 49.80  ? 290 LYS   R CB  1 
ATOM   2091 C CG  . LYS   A 1 428 ? 115.255 146.425 121.558 1.00 53.36  ? 290 LYS   R CG  1 
ATOM   2092 C CD  . LYS   A 1 428 ? 114.499 147.740 121.543 1.00 56.59  ? 290 LYS   R CD  1 
ATOM   2093 C CE  . LYS   A 1 428 ? 113.836 147.975 120.197 1.00 59.53  ? 290 LYS   R CE  1 
ATOM   2094 N NZ  . LYS   A 1 428 ? 112.642 148.854 120.319 1.00 60.76  ? 290 LYS   R NZ  1 
ATOM   2095 N N   . TRP   A 1 429 ? 117.091 144.657 125.083 1.00 47.43  ? 291 TRP   R N   1 
ATOM   2096 C CA  . TRP   A 1 429 ? 117.678 144.505 126.408 1.00 42.27  ? 291 TRP   R CA  1 
ATOM   2097 C C   . TRP   A 1 429 ? 118.881 143.575 126.358 1.00 44.00  ? 291 TRP   R C   1 
ATOM   2098 O O   . TRP   A 1 429 ? 119.949 143.905 126.882 1.00 45.18  ? 291 TRP   R O   1 
ATOM   2099 C CB  . TRP   A 1 429 ? 116.606 143.995 127.380 1.00 45.08  ? 291 TRP   R CB  1 
ATOM   2100 C CG  . TRP   A 1 429 ? 117.049 143.621 128.787 1.00 51.39  ? 291 TRP   R CG  1 
ATOM   2101 C CD1 . TRP   A 1 429 ? 118.130 142.867 129.155 1.00 51.69  ? 291 TRP   R CD1 1 
ATOM   2102 C CD2 . TRP   A 1 429 ? 116.395 143.993 130.006 1.00 50.29  ? 291 TRP   R CD2 1 
ATOM   2103 N NE1 . TRP   A 1 429 ? 118.189 142.753 130.521 1.00 40.44  ? 291 TRP   R NE1 1 
ATOM   2104 C CE2 . TRP   A 1 429 ? 117.135 143.435 131.067 1.00 43.44  ? 291 TRP   R CE2 1 
ATOM   2105 C CE3 . TRP   A 1 429 ? 115.256 144.747 130.303 1.00 51.63  ? 291 TRP   R CE3 1 
ATOM   2106 C CZ2 . TRP   A 1 429 ? 116.774 143.607 132.399 1.00 48.25  ? 291 TRP   R CZ2 1 
ATOM   2107 C CZ3 . TRP   A 1 429 ? 114.899 144.917 131.626 1.00 53.32  ? 291 TRP   R CZ3 1 
ATOM   2108 C CH2 . TRP   A 1 429 ? 115.655 144.349 132.658 1.00 53.78  ? 291 TRP   R CH2 1 
ATOM   2109 N N   . ILE   A 1 430 ? 118.735 142.422 125.703 1.00 45.41  ? 292 ILE   R N   1 
ATOM   2110 C CA  . ILE   A 1 430 ? 119.826 141.456 125.635 1.00 47.54  ? 292 ILE   R CA  1 
ATOM   2111 C C   . ILE   A 1 430 ? 120.998 142.022 124.848 1.00 51.05  ? 292 ILE   R C   1 
ATOM   2112 O O   . ILE   A 1 430 ? 122.159 141.827 125.222 1.00 49.47  ? 292 ILE   R O   1 
ATOM   2113 C CB  . ILE   A 1 430 ? 119.334 140.129 125.032 1.00 43.31  ? 292 ILE   R CB  1 
ATOM   2114 C CG1 . ILE   A 1 430 ? 118.375 139.432 125.988 1.00 44.18  ? 292 ILE   R CG1 1 
ATOM   2115 C CG2 . ILE   A 1 430 ? 120.503 139.209 124.745 1.00 42.96  ? 292 ILE   R CG2 1 
ATOM   2116 C CD1 . ILE   A 1 430 ? 117.650 138.288 125.351 1.00 48.90  ? 292 ILE   R CD1 1 
ATOM   2117 N N   . SER   A 1 431 ? 120.723 142.720 123.743 1.00 45.31  ? 293 SER   R N   1 
ATOM   2118 C CA  . SER   A 1 431 ? 121.814 143.260 122.934 1.00 40.16  ? 293 SER   R CA  1 
ATOM   2119 C C   . SER   A 1 431 ? 122.633 144.281 123.719 1.00 42.79  ? 293 SER   R C   1 
ATOM   2120 O O   . SER   A 1 431 ? 123.867 144.180 123.806 1.00 40.42  ? 293 SER   R O   1 
ATOM   2121 C CB  . SER   A 1 431 ? 121.259 143.883 121.655 1.00 43.62  ? 293 SER   R CB  1 
ATOM   2122 O OG  . SER   A 1 431 ? 122.305 144.415 120.861 1.00 50.59  ? 293 SER   R OG  1 
ATOM   2123 N N   . ILE   A 1 432 ? 121.955 145.266 124.315 1.00 47.32  ? 294 ILE   R N   1 
ATOM   2124 C CA  . ILE   A 1 432 ? 122.651 146.283 125.097 1.00 46.53  ? 294 ILE   R CA  1 
ATOM   2125 C C   . ILE   A 1 432 ? 123.365 145.646 126.283 1.00 48.22  ? 294 ILE   R C   1 
ATOM   2126 O O   . ILE   A 1 432 ? 124.498 146.017 126.621 1.00 49.18  ? 294 ILE   R O   1 
ATOM   2127 C CB  . ILE   A 1 432 ? 121.662 147.377 125.543 1.00 41.33  ? 294 ILE   R CB  1 
ATOM   2128 C CG1 . ILE   A 1 432 ? 121.356 148.321 124.382 1.00 40.10  ? 294 ILE   R CG1 1 
ATOM   2129 C CG2 . ILE   A 1 432 ? 122.207 148.155 126.725 1.00 41.91  ? 294 ILE   R CG2 1 
ATOM   2130 C CD1 . ILE   A 1 432 ? 120.076 149.100 124.556 1.00 40.97  ? 294 ILE   R CD1 1 
ATOM   2131 N N   . THR   A 1 433 ? 122.729 144.657 126.915 1.00 42.08  ? 295 THR   R N   1 
ATOM   2132 C CA  . THR   A 1 433 ? 123.305 144.043 128.102 1.00 35.75  ? 295 THR   R CA  1 
ATOM   2133 C C   . THR   A 1 433 ? 124.542 143.221 127.771 1.00 49.98  ? 295 THR   R C   1 
ATOM   2134 O O   . THR   A 1 433 ? 125.499 143.208 128.548 1.00 50.32  ? 295 THR   R O   1 
ATOM   2135 C CB  . THR   A 1 433 ? 122.263 143.178 128.797 1.00 37.74  ? 295 THR   R CB  1 
ATOM   2136 O OG1 . THR   A 1 433 ? 121.017 143.881 128.840 1.00 42.49  ? 295 THR   R OG1 1 
ATOM   2137 C CG2 . THR   A 1 433 ? 122.706 142.888 130.202 1.00 45.35  ? 295 THR   R CG2 1 
ATOM   2138 N N   . GLU   A 1 434 ? 124.550 142.519 126.635 1.00 44.83  ? 296 GLU   R N   1 
ATOM   2139 C CA  . GLU   A 1 434 ? 125.750 141.777 126.260 1.00 32.98  ? 296 GLU   R CA  1 
ATOM   2140 C C   . GLU   A 1 434 ? 126.864 142.726 125.844 1.00 40.61  ? 296 GLU   R C   1 
ATOM   2141 O O   . GLU   A 1 434 ? 128.041 142.484 126.149 1.00 42.63  ? 296 GLU   R O   1 
ATOM   2142 C CB  . GLU   A 1 434 ? 125.440 140.765 125.153 1.00 30.50  ? 296 GLU   R CB  1 
ATOM   2143 C CG  . GLU   A 1 434 ? 125.509 141.285 123.727 1.00 42.20  ? 296 GLU   R CG  1 
ATOM   2144 C CD  . GLU   A 1 434 ? 125.642 140.168 122.705 1.00 45.29  ? 296 GLU   R CD  1 
ATOM   2145 O OE1 . GLU   A 1 434 ? 125.687 138.990 123.114 1.00 43.49  ? 296 GLU   R OE1 1 
ATOM   2146 O OE2 . GLU   A 1 434 ? 125.696 140.464 121.493 1.00 40.79  ? 296 GLU   R OE2 1 
ATOM   2147 N N   . ALA   A 1 435 ? 126.510 143.836 125.187 1.00 41.11  ? 297 ALA   R N   1 
ATOM   2148 C CA  . ALA   A 1 435 ? 127.521 144.837 124.869 1.00 40.69  ? 297 ALA   R CA  1 
ATOM   2149 C C   . ALA   A 1 435 ? 128.164 145.382 126.137 1.00 39.98  ? 297 ALA   R C   1 
ATOM   2150 O O   . ALA   A 1 435 ? 129.383 145.580 126.189 1.00 40.35  ? 297 ALA   R O   1 
ATOM   2151 C CB  . ALA   A 1 435 ? 126.904 145.966 124.046 1.00 39.17  ? 297 ALA   R CB  1 
ATOM   2152 N N   . LEU   A 1 436 ? 127.360 145.620 127.175 1.00 35.76  ? 298 LEU   R N   1 
ATOM   2153 C CA  . LEU   A 1 436 ? 127.905 146.121 128.433 1.00 33.28  ? 298 LEU   R CA  1 
ATOM   2154 C C   . LEU   A 1 436 ? 128.654 145.047 129.215 1.00 34.30  ? 298 LEU   R C   1 
ATOM   2155 O O   . LEU   A 1 436 ? 129.651 145.354 129.876 1.00 38.32  ? 298 LEU   R O   1 
ATOM   2156 C CB  . LEU   A 1 436 ? 126.787 146.706 129.295 1.00 36.77  ? 298 LEU   R CB  1 
ATOM   2157 C CG  . LEU   A 1 436 ? 126.238 148.064 128.855 1.00 38.72  ? 298 LEU   R CG  1 
ATOM   2158 C CD1 . LEU   A 1 436 ? 124.892 148.330 129.504 1.00 41.14  ? 298 LEU   R CD1 1 
ATOM   2159 C CD2 . LEU   A 1 436 ? 127.221 149.171 129.184 1.00 36.75  ? 298 LEU   R CD2 1 
ATOM   2160 N N   . ALA   A 1 437 ? 128.198 143.795 129.157 1.00 35.89  ? 299 ALA   R N   1 
ATOM   2161 C CA  . ALA   A 1 437 ? 128.821 142.702 129.890 1.00 32.05  ? 299 ALA   R CA  1 
ATOM   2162 C C   . ALA   A 1 437 ? 130.103 142.209 129.242 1.00 35.06  ? 299 ALA   R C   1 
ATOM   2163 O O   . ALA   A 1 437 ? 130.848 141.459 129.880 1.00 24.72  ? 299 ALA   R O   1 
ATOM   2164 C CB  . ALA   A 1 437 ? 127.841 141.538 130.033 1.00 26.36  ? 299 ALA   R CB  1 
ATOM   2165 N N   . PHE   A 1 438 ? 130.374 142.600 127.996 1.00 44.65  ? 300 PHE   R N   1 
ATOM   2166 C CA  . PHE   A 1 438 ? 131.696 142.354 127.427 1.00 40.28  ? 300 PHE   R CA  1 
ATOM   2167 C C   . PHE   A 1 438 ? 132.805 143.112 128.147 1.00 40.23  ? 300 PHE   R C   1 
ATOM   2168 O O   . PHE   A 1 438 ? 133.972 142.949 127.779 1.00 39.00  ? 300 PHE   R O   1 
ATOM   2169 C CB  . PHE   A 1 438 ? 131.715 142.723 125.945 1.00 34.08  ? 300 PHE   R CB  1 
ATOM   2170 C CG  . PHE   A 1 438 ? 131.048 141.713 125.064 1.00 33.47  ? 300 PHE   R CG  1 
ATOM   2171 C CD1 . PHE   A 1 438 ? 130.927 140.397 125.466 1.00 37.50  ? 300 PHE   R CD1 1 
ATOM   2172 C CD2 . PHE   A 1 438 ? 130.538 142.082 123.835 1.00 31.43  ? 300 PHE   R CD2 1 
ATOM   2173 C CE1 . PHE   A 1 438 ? 130.312 139.472 124.659 1.00 36.92  ? 300 PHE   R CE1 1 
ATOM   2174 C CE2 . PHE   A 1 438 ? 129.923 141.161 123.030 1.00 30.47  ? 300 PHE   R CE2 1 
ATOM   2175 C CZ  . PHE   A 1 438 ? 129.810 139.854 123.439 1.00 32.83  ? 300 PHE   R CZ  1 
ATOM   2176 N N   . PHE   A 1 439 ? 132.478 143.934 129.147 1.00 38.45  ? 301 PHE   R N   1 
ATOM   2177 C CA  . PHE   A 1 439 ? 133.483 144.682 129.892 1.00 32.69  ? 301 PHE   R CA  1 
ATOM   2178 C C   . PHE   A 1 439 ? 134.330 143.805 130.801 1.00 42.41  ? 301 PHE   R C   1 
ATOM   2179 O O   . PHE   A 1 439 ? 135.321 144.295 131.351 1.00 46.55  ? 301 PHE   R O   1 
ATOM   2180 C CB  . PHE   A 1 439 ? 132.818 145.776 130.726 1.00 30.29  ? 301 PHE   R CB  1 
ATOM   2181 C CG  . PHE   A 1 439 ? 132.986 147.153 130.159 1.00 37.35  ? 301 PHE   R CG  1 
ATOM   2182 C CD1 . PHE   A 1 439 ? 134.171 147.845 130.334 1.00 41.10  ? 301 PHE   R CD1 1 
ATOM   2183 C CD2 . PHE   A 1 439 ? 131.960 147.757 129.456 1.00 41.51  ? 301 PHE   R CD2 1 
ATOM   2184 C CE1 . PHE   A 1 439 ? 134.330 149.112 129.814 1.00 44.83  ? 301 PHE   R CE1 1 
ATOM   2185 C CE2 . PHE   A 1 439 ? 132.113 149.025 128.933 1.00 43.86  ? 301 PHE   R CE2 1 
ATOM   2186 C CZ  . PHE   A 1 439 ? 133.298 149.703 129.113 1.00 44.09  ? 301 PHE   R CZ  1 
ATOM   2187 N N   . HIS   A 1 440 ? 133.968 142.531 130.977 1.00 45.63  ? 302 HIS   R N   1 
ATOM   2188 C CA  . HIS   A 1 440 ? 134.739 141.650 131.845 1.00 41.09  ? 302 HIS   R CA  1 
ATOM   2189 C C   . HIS   A 1 440 ? 136.174 141.485 131.367 1.00 40.65  ? 302 HIS   R C   1 
ATOM   2190 O O   . HIS   A 1 440 ? 137.040 141.102 132.160 1.00 39.02  ? 302 HIS   R O   1 
ATOM   2191 C CB  . HIS   A 1 440 ? 134.055 140.287 131.947 1.00 32.91  ? 302 HIS   R CB  1 
ATOM   2192 C CG  . HIS   A 1 440 ? 134.303 139.395 130.771 1.00 41.40  ? 302 HIS   R CG  1 
ATOM   2193 N ND1 . HIS   A 1 440 ? 133.457 139.344 129.686 1.00 47.40  ? 302 HIS   R ND1 1 
ATOM   2194 C CD2 . HIS   A 1 440 ? 135.298 138.515 130.513 1.00 42.07  ? 302 HIS   R CD2 1 
ATOM   2195 C CE1 . HIS   A 1 440 ? 133.923 138.476 128.807 1.00 39.33  ? 302 HIS   R CE1 1 
ATOM   2196 N NE2 . HIS   A 1 440 ? 135.040 137.959 129.285 1.00 37.96  ? 302 HIS   R NE2 1 
ATOM   2197 N N   . CYS   A 1 441 ? 136.444 141.767 130.092 1.00 40.70  ? 303 CYS   R N   1 
ATOM   2198 C CA  . CYS   A 1 441 ? 137.800 141.668 129.571 1.00 42.43  ? 303 CYS   R CA  1 
ATOM   2199 C C   . CYS   A 1 441 ? 138.731 142.713 130.168 1.00 50.25  ? 303 CYS   R C   1 
ATOM   2200 O O   . CYS   A 1 441 ? 139.950 142.519 130.144 1.00 57.45  ? 303 CYS   R O   1 
ATOM   2201 C CB  . CYS   A 1 441 ? 137.785 141.798 128.048 1.00 39.35  ? 303 CYS   R CB  1 
ATOM   2202 S SG  . CYS   A 1 441 ? 136.631 140.683 127.221 1.00 57.10  ? 303 CYS   R SG  1 
ATOM   2203 N N   . CYS   A 1 442 ? 138.193 143.811 130.694 1.00 47.36  ? 304 CYS   R N   1 
ATOM   2204 C CA  . CYS   A 1 442 ? 139.002 144.899 131.224 1.00 38.35  ? 304 CYS   R CA  1 
ATOM   2205 C C   . CYS   A 1 442 ? 139.128 144.877 132.742 1.00 43.23  ? 304 CYS   R C   1 
ATOM   2206 O O   . CYS   A 1 442 ? 139.778 145.762 133.303 1.00 55.05  ? 304 CYS   R O   1 
ATOM   2207 C CB  . CYS   A 1 442 ? 138.423 146.244 130.778 1.00 38.31  ? 304 CYS   R CB  1 
ATOM   2208 S SG  . CYS   A 1 442 ? 137.867 146.279 129.062 1.00 63.93  ? 304 CYS   R SG  1 
ATOM   2209 N N   . LEU   A 1 443 ? 138.530 143.895 133.419 1.00 43.84  ? 305 LEU   R N   1 
ATOM   2210 C CA  . LEU   A 1 443 ? 138.555 143.886 134.880 1.00 41.23  ? 305 LEU   R CA  1 
ATOM   2211 C C   . LEU   A 1 443 ? 139.962 143.668 135.421 1.00 42.96  ? 305 LEU   R C   1 
ATOM   2212 O O   . LEU   A 1 443 ? 140.384 144.361 136.353 1.00 47.56  ? 305 LEU   R O   1 
ATOM   2213 C CB  . LEU   A 1 443 ? 137.612 142.812 135.417 1.00 40.02  ? 305 LEU   R CB  1 
ATOM   2214 C CG  . LEU   A 1 443 ? 136.138 142.953 135.051 1.00 41.36  ? 305 LEU   R CG  1 
ATOM   2215 C CD1 . LEU   A 1 443 ? 135.342 141.835 135.686 1.00 42.79  ? 305 LEU   R CD1 1 
ATOM   2216 C CD2 . LEU   A 1 443 ? 135.603 144.308 135.481 1.00 39.55  ? 305 LEU   R CD2 1 
ATOM   2217 N N   . ASN   A 1 444 ? 140.698 142.710 134.859 1.00 46.03  ? 306 ASN   R N   1 
ATOM   2218 C CA  . ASN   A 1 444 ? 142.028 142.397 135.379 1.00 42.20  ? 306 ASN   R CA  1 
ATOM   2219 C C   . ASN   A 1 444 ? 142.988 143.575 135.306 1.00 43.05  ? 306 ASN   R C   1 
ATOM   2220 O O   . ASN   A 1 444 ? 143.631 143.879 136.325 1.00 49.93  ? 306 ASN   R O   1 
ATOM   2221 C CB  . ASN   A 1 444 ? 142.599 141.183 134.642 1.00 49.30  ? 306 ASN   R CB  1 
ATOM   2222 C CG  . ASN   A 1 444 ? 141.814 139.927 134.901 1.00 50.68  ? 306 ASN   R CG  1 
ATOM   2223 O OD1 . ASN   A 1 444 ? 141.493 139.602 136.042 1.00 55.91  ? 306 ASN   R OD1 1 
ATOM   2224 N ND2 . ASN   A 1 444 ? 141.478 139.220 133.834 1.00 45.74  ? 306 ASN   R ND2 1 
ATOM   2225 N N   . PRO   A 1 445 ? 143.156 144.263 134.169 1.00 33.71  ? 307 PRO   R N   1 
ATOM   2226 C CA  . PRO   A 1 445 ? 144.096 145.395 134.162 1.00 37.43  ? 307 PRO   R CA  1 
ATOM   2227 C C   . PRO   A 1 445 ? 143.664 146.539 135.061 1.00 44.99  ? 307 PRO   R C   1 
ATOM   2228 O O   . PRO   A 1 445 ? 144.509 147.161 135.710 1.00 48.06  ? 307 PRO   R O   1 
ATOM   2229 C CB  . PRO   A 1 445 ? 144.131 145.810 132.684 1.00 43.19  ? 307 PRO   R CB  1 
ATOM   2230 C CG  . PRO   A 1 445 ? 143.583 144.643 131.935 1.00 40.41  ? 307 PRO   R CG  1 
ATOM   2231 C CD  . PRO   A 1 445 ? 142.562 144.057 132.838 1.00 36.57  ? 307 PRO   R CD  1 
ATOM   2232 N N   . ILE   A 1 446 ? 142.364 146.830 135.124 1.00 38.63  ? 308 ILE   R N   1 
ATOM   2233 C CA  . ILE   A 1 446 ? 141.884 147.906 135.988 1.00 29.87  ? 308 ILE   R CA  1 
ATOM   2234 C C   . ILE   A 1 446 ? 142.107 147.553 137.453 1.00 35.50  ? 308 ILE   R C   1 
ATOM   2235 O O   . ILE   A 1 446 ? 142.511 148.402 138.260 1.00 43.86  ? 308 ILE   R O   1 
ATOM   2236 C CB  . ILE   A 1 446 ? 140.405 148.205 135.685 1.00 32.26  ? 308 ILE   R CB  1 
ATOM   2237 C CG1 . ILE   A 1 446 ? 140.261 148.774 134.274 1.00 34.85  ? 308 ILE   R CG1 1 
ATOM   2238 C CG2 . ILE   A 1 446 ? 139.839 149.181 136.688 1.00 46.82  ? 308 ILE   R CG2 1 
ATOM   2239 C CD1 . ILE   A 1 446 ? 138.833 148.827 133.779 1.00 38.04  ? 308 ILE   R CD1 1 
ATOM   2240 N N   . LEU   A 1 447 ? 141.835 146.298 137.823 1.00 40.84  ? 309 LEU   R N   1 
ATOM   2241 C CA  . LEU   A 1 447 ? 142.092 145.851 139.188 1.00 40.54  ? 309 LEU   R CA  1 
ATOM   2242 C C   . LEU   A 1 447 ? 143.573 145.931 139.525 1.00 46.29  ? 309 LEU   R C   1 
ATOM   2243 O O   . LEU   A 1 447 ? 143.945 146.358 140.623 1.00 53.52  ? 309 LEU   R O   1 
ATOM   2244 C CB  . LEU   A 1 447 ? 141.581 144.424 139.382 1.00 43.27  ? 309 LEU   R CB  1 
ATOM   2245 C CG  . LEU   A 1 447 ? 140.192 144.243 139.989 1.00 44.61  ? 309 LEU   R CG  1 
ATOM   2246 C CD1 . LEU   A 1 447 ? 140.253 144.433 141.493 1.00 44.25  ? 309 LEU   R CD1 1 
ATOM   2247 C CD2 . LEU   A 1 447 ? 139.195 145.202 139.368 1.00 45.97  ? 309 LEU   R CD2 1 
ATOM   2248 N N   . TYR   A 1 448 ? 144.435 145.521 138.594 1.00 47.11  ? 310 TYR   R N   1 
ATOM   2249 C CA  . TYR   A 1 448 ? 145.872 145.646 138.813 1.00 43.99  ? 310 TYR   R CA  1 
ATOM   2250 C C   . TYR   A 1 448 ? 146.279 147.105 138.959 1.00 53.79  ? 310 TYR   R C   1 
ATOM   2251 O O   . TYR   A 1 448 ? 147.192 147.430 139.727 1.00 59.98  ? 310 TYR   R O   1 
ATOM   2252 C CB  . TYR   A 1 448 ? 146.635 144.997 137.662 1.00 47.96  ? 310 TYR   R CB  1 
ATOM   2253 C CG  . TYR   A 1 448 ? 146.934 143.533 137.863 1.00 53.21  ? 310 TYR   R CG  1 
ATOM   2254 C CD1 . TYR   A 1 448 ? 147.754 143.112 138.898 1.00 56.58  ? 310 TYR   R CD1 1 
ATOM   2255 C CD2 . TYR   A 1 448 ? 146.399 142.572 137.017 1.00 55.83  ? 310 TYR   R CD2 1 
ATOM   2256 C CE1 . TYR   A 1 448 ? 148.035 141.776 139.084 1.00 57.86  ? 310 TYR   R CE1 1 
ATOM   2257 C CE2 . TYR   A 1 448 ? 146.673 141.233 137.196 1.00 54.88  ? 310 TYR   R CE2 1 
ATOM   2258 C CZ  . TYR   A 1 448 ? 147.489 140.841 138.232 1.00 53.17  ? 310 TYR   R CZ  1 
ATOM   2259 O OH  . TYR   A 1 448 ? 147.772 139.509 138.419 1.00 53.48  ? 310 TYR   R OH  1 
ATOM   2260 N N   . ALA   A 1 449 ? 145.628 147.997 138.213 1.00 46.48  ? 311 ALA   R N   1 
ATOM   2261 C CA  . ALA   A 1 449 ? 145.993 149.407 138.249 1.00 47.12  ? 311 ALA   R CA  1 
ATOM   2262 C C   . ALA   A 1 449 ? 145.616 150.048 139.577 1.00 51.97  ? 311 ALA   R C   1 
ATOM   2263 O O   . ALA   A 1 449 ? 146.444 150.714 140.209 1.00 51.62  ? 311 ALA   R O   1 
ATOM   2264 C CB  . ALA   A 1 449 ? 145.332 150.148 137.088 1.00 46.11  ? 311 ALA   R CB  1 
ATOM   2265 N N   . PHE   A 1 450 ? 144.377 149.861 140.026 1.00 54.58  ? 312 PHE   R N   1 
ATOM   2266 C CA  . PHE   A 1 450 ? 143.951 150.577 141.224 1.00 50.40  ? 312 PHE   R CA  1 
ATOM   2267 C C   . PHE   A 1 450 ? 144.067 149.747 142.500 1.00 49.89  ? 312 PHE   R C   1 
ATOM   2268 O O   . PHE   A 1 450 ? 143.696 150.237 143.571 1.00 58.91  ? 312 PHE   R O   1 
ATOM   2269 C CB  . PHE   A 1 450 ? 142.534 151.174 141.035 1.00 50.92  ? 312 PHE   R CB  1 
ATOM   2270 C CG  . PHE   A 1 450 ? 141.381 150.198 141.150 1.00 51.14  ? 312 PHE   R CG  1 
ATOM   2271 C CD1 . PHE   A 1 450 ? 141.012 149.654 142.369 1.00 55.31  ? 312 PHE   R CD1 1 
ATOM   2272 C CD2 . PHE   A 1 450 ? 140.613 149.895 140.042 1.00 52.24  ? 312 PHE   R CD2 1 
ATOM   2273 C CE1 . PHE   A 1 450 ? 139.942 148.788 142.467 1.00 56.05  ? 312 PHE   R CE1 1 
ATOM   2274 C CE2 . PHE   A 1 450 ? 139.540 149.028 140.135 1.00 54.97  ? 312 PHE   R CE2 1 
ATOM   2275 C CZ  . PHE   A 1 450 ? 139.205 148.476 141.349 1.00 56.99  ? 312 PHE   R CZ  1 
ATOM   2276 N N   . LEU   A 1 451 ? 144.607 148.529 142.422 1.00 53.11  ? 313 LEU   R N   1 
ATOM   2277 C CA  . LEU   A 1 451 ? 145.055 147.787 143.597 1.00 57.97  ? 313 LEU   R CA  1 
ATOM   2278 C C   . LEU   A 1 451 ? 146.549 147.493 143.575 1.00 61.38  ? 313 LEU   R C   1 
ATOM   2279 O O   . LEU   A 1 451 ? 147.030 146.735 144.424 1.00 66.84  ? 313 LEU   R O   1 
ATOM   2280 C CB  . LEU   A 1 451 ? 144.287 146.471 143.750 1.00 59.51  ? 313 LEU   R CB  1 
ATOM   2281 C CG  . LEU   A 1 451 ? 142.773 146.499 143.921 1.00 60.56  ? 313 LEU   R CG  1 
ATOM   2282 C CD1 . LEU   A 1 451 ? 142.326 145.215 144.579 1.00 58.19  ? 313 LEU   R CD1 1 
ATOM   2283 C CD2 . LEU   A 1 451 ? 142.397 147.663 144.809 1.00 58.76  ? 313 LEU   R CD2 1 
ATOM   2284 N N   . GLY   A 1 452 ? 147.293 148.058 142.629 1.00 63.40  ? 314 GLY   R N   1 
ATOM   2285 C CA  . GLY   A 1 452 ? 148.709 147.764 142.520 1.00 64.97  ? 314 GLY   R CA  1 
ATOM   2286 C C   . GLY   A 1 452 ? 149.588 148.996 142.518 1.00 68.42  ? 314 GLY   R C   1 
ATOM   2287 O O   . GLY   A 1 452 ? 150.701 148.971 141.985 1.00 68.95  ? 314 GLY   R O   1 
ATOM   2288 N N   . ALA   A 1 453 ? 149.097 150.084 143.101 1.00 74.25  ? 315 ALA   R N   1 
ATOM   2289 C CA  . ALA   A 1 453 ? 149.873 151.315 143.186 1.00 74.64  ? 315 ALA   R CA  1 
ATOM   2290 C C   . ALA   A 1 453 ? 149.879 151.868 144.610 1.00 73.14  ? 315 ALA   R C   1 
ATOM   2291 O O   . ALA   A 1 453 ? 148.840 152.255 145.144 1.00 72.72  ? 315 ALA   R O   1 
ATOM   2292 C CB  . ALA   A 1 453 ? 149.331 152.351 142.217 1.00 72.49  ? 315 ALA   R CB  1 
ATOM   2293 N N   . GLN   B 2 41  ? 140.250 152.705 164.683 1.00 83.64  ? 3   GLN   N N   1 
ATOM   2294 C CA  . GLN   B 2 41  ? 140.934 152.566 165.963 1.00 83.80  ? 3   GLN   N CA  1 
ATOM   2295 C C   . GLN   B 2 41  ? 139.963 152.139 167.057 1.00 84.86  ? 3   GLN   N C   1 
ATOM   2296 O O   . GLN   B 2 41  ? 138.748 152.171 166.868 1.00 86.86  ? 3   GLN   N O   1 
ATOM   2297 C CB  . GLN   B 2 41  ? 141.621 153.876 166.351 1.00 84.45  ? 3   GLN   N CB  1 
ATOM   2298 N N   . VAL   B 2 42  ? 140.511 151.734 168.203 1.00 86.11  ? 4   VAL   N N   1 
ATOM   2299 C CA  . VAL   B 2 42  ? 139.724 151.283 169.342 1.00 85.80  ? 4   VAL   N CA  1 
ATOM   2300 C C   . VAL   B 2 42  ? 140.190 152.031 170.583 1.00 87.50  ? 4   VAL   N C   1 
ATOM   2301 O O   . VAL   B 2 42  ? 141.275 152.616 170.616 1.00 90.47  ? 4   VAL   N O   1 
ATOM   2302 C CB  . VAL   B 2 42  ? 139.826 149.759 169.567 1.00 84.61  ? 4   VAL   N CB  1 
ATOM   2303 C CG1 . VAL   B 2 42  ? 139.568 149.008 168.272 1.00 84.14  ? 4   VAL   N CG1 1 
ATOM   2304 C CG2 . VAL   B 2 42  ? 141.187 149.398 170.137 1.00 84.21  ? 4   VAL   N CG2 1 
ATOM   2305 N N   . GLN   B 2 43  ? 139.347 152.010 171.612 1.00 88.71  ? 5   GLN   N N   1 
ATOM   2306 C CA  . GLN   B 2 43  ? 139.637 152.682 172.871 1.00 89.70  ? 5   GLN   N CA  1 
ATOM   2307 C C   . GLN   B 2 43  ? 139.385 151.727 174.026 1.00 90.55  ? 5   GLN   N C   1 
ATOM   2308 O O   . GLN   B 2 43  ? 138.263 151.239 174.195 1.00 91.55  ? 5   GLN   N O   1 
ATOM   2309 C CB  . GLN   B 2 43  ? 138.786 153.946 173.032 1.00 89.99  ? 5   GLN   N CB  1 
ATOM   2310 N N   . LEU   B 2 44  ? 140.422 151.471 174.820 1.00 98.44  ? 6   LEU   N N   1 
ATOM   2311 C CA  . LEU   B 2 44  ? 140.326 150.633 176.008 1.00 99.85  ? 6   LEU   N CA  1 
ATOM   2312 C C   . LEU   B 2 44  ? 140.499 151.501 177.245 1.00 99.76  ? 6   LEU   N C   1 
ATOM   2313 O O   . LEU   B 2 44  ? 141.468 152.261 177.344 1.00 101.07 ? 6   LEU   N O   1 
ATOM   2314 C CB  . LEU   B 2 44  ? 141.379 149.521 175.996 1.00 98.17  ? 6   LEU   N CB  1 
ATOM   2315 C CG  . LEU   B 2 44  ? 141.000 148.205 175.312 1.00 97.84  ? 6   LEU   N CG  1 
ATOM   2316 C CD1 . LEU   B 2 44  ? 141.204 148.297 173.808 1.00 99.93  ? 6   LEU   N CD1 1 
ATOM   2317 C CD2 . LEU   B 2 44  ? 141.791 147.046 175.894 1.00 96.21  ? 6   LEU   N CD2 1 
ATOM   2318 N N   . GLN   B 2 45  ? 139.564 151.385 178.183 1.00 105.65 ? 7   GLN   N N   1 
ATOM   2319 C CA  . GLN   B 2 45  ? 139.594 152.140 179.427 1.00 106.24 ? 7   GLN   N CA  1 
ATOM   2320 C C   . GLN   B 2 45  ? 139.625 151.177 180.603 1.00 106.33 ? 7   GLN   N C   1 
ATOM   2321 O O   . GLN   B 2 45  ? 138.947 150.145 180.591 1.00 106.84 ? 7   GLN   N O   1 
ATOM   2322 C CB  . GLN   B 2 45  ? 138.380 153.070 179.546 1.00 107.94 ? 7   GLN   N CB  1 
ATOM   2323 C CG  . GLN   B 2 45  ? 137.919 153.676 178.230 1.00 107.33 ? 7   GLN   N CG  1 
ATOM   2324 C CD  . GLN   B 2 45  ? 136.472 154.128 178.274 1.00 108.69 ? 7   GLN   N CD  1 
ATOM   2325 O OE1 . GLN   B 2 45  ? 135.706 153.714 179.144 1.00 109.17 ? 7   GLN   N OE1 1 
ATOM   2326 N NE2 . GLN   B 2 45  ? 136.091 154.984 177.332 1.00 108.76 ? 7   GLN   N NE2 1 
ATOM   2327 N N   . GLU   B 2 46  ? 140.411 151.517 181.618 1.00 112.15 ? 8   GLU   N N   1 
ATOM   2328 C CA  . GLU   B 2 46  ? 140.554 150.691 182.805 1.00 113.64 ? 8   GLU   N CA  1 
ATOM   2329 C C   . GLU   B 2 46  ? 139.972 151.408 184.016 1.00 115.30 ? 8   GLU   N C   1 
ATOM   2330 O O   . GLU   B 2 46  ? 140.077 152.631 184.146 1.00 115.60 ? 8   GLU   N O   1 
ATOM   2331 C CB  . GLU   B 2 46  ? 142.021 150.356 183.072 1.00 113.76 ? 8   GLU   N CB  1 
ATOM   2332 C CG  . GLU   B 2 46  ? 142.721 149.623 181.948 1.00 114.09 ? 8   GLU   N CG  1 
ATOM   2333 C CD  . GLU   B 2 46  ? 144.134 149.234 182.323 1.00 114.34 ? 8   GLU   N CD  1 
ATOM   2334 O OE1 . GLU   B 2 46  ? 144.527 149.492 183.478 1.00 114.93 ? 8   GLU   N OE1 1 
ATOM   2335 O OE2 . GLU   B 2 46  ? 144.859 148.690 181.465 1.00 114.65 ? 8   GLU   N OE2 1 
ATOM   2336 N N   . SER   B 2 47  ? 139.359 150.631 184.905 1.00 122.33 ? 9   SER   N N   1 
ATOM   2337 C CA  . SER   B 2 47  ? 138.794 151.176 186.131 1.00 122.48 ? 9   SER   N CA  1 
ATOM   2338 C C   . SER   B 2 47  ? 138.749 150.074 187.178 1.00 123.41 ? 9   SER   N C   1 
ATOM   2339 O O   . SER   B 2 47  ? 138.788 148.884 186.855 1.00 123.19 ? 9   SER   N O   1 
ATOM   2340 C CB  . SER   B 2 47  ? 137.397 151.761 185.898 1.00 122.70 ? 9   SER   N CB  1 
ATOM   2341 O OG  . SER   B 2 47  ? 136.409 150.745 185.912 1.00 123.18 ? 9   SER   N OG  1 
ATOM   2342 N N   . GLY   B 2 48  ? 138.666 150.489 188.439 1.00 133.88 ? 10  GLY   N N   1 
ATOM   2343 C CA  . GLY   B 2 48  ? 138.584 149.548 189.538 1.00 133.62 ? 10  GLY   N CA  1 
ATOM   2344 C C   . GLY   B 2 48  ? 139.672 149.729 190.576 1.00 133.64 ? 10  GLY   N C   1 
ATOM   2345 O O   . GLY   B 2 48  ? 139.587 149.175 191.676 1.00 132.91 ? 10  GLY   N O   1 
ATOM   2346 N N   . GLY   B 2 49  ? 140.700 150.505 190.242 1.00 142.33 ? 11  GLY   N N   1 
ATOM   2347 C CA  . GLY   B 2 49  ? 141.793 150.745 191.156 1.00 143.39 ? 11  GLY   N CA  1 
ATOM   2348 C C   . GLY   B 2 49  ? 141.450 151.769 192.220 1.00 144.57 ? 11  GLY   N C   1 
ATOM   2349 O O   . GLY   B 2 49  ? 140.386 152.388 192.225 1.00 144.66 ? 11  GLY   N O   1 
ATOM   2350 N N   . GLY   B 2 50  ? 142.384 151.944 193.143 1.00 152.39 ? 12  GLY   N N   1 
ATOM   2351 C CA  . GLY   B 2 50  ? 142.241 152.878 194.234 1.00 151.81 ? 12  GLY   N CA  1 
ATOM   2352 C C   . GLY   B 2 50  ? 142.783 152.282 195.513 1.00 152.68 ? 12  GLY   N C   1 
ATOM   2353 O O   . GLY   B 2 50  ? 143.404 151.220 195.516 1.00 152.61 ? 12  GLY   N O   1 
ATOM   2354 N N   . LEU   B 2 51  ? 142.539 152.982 196.618 1.00 159.39 ? 13  LEU   N N   1 
ATOM   2355 C CA  . LEU   B 2 51  ? 142.987 152.545 197.936 1.00 159.41 ? 13  LEU   N CA  1 
ATOM   2356 C C   . LEU   B 2 51  ? 141.832 151.834 198.632 1.00 159.56 ? 13  LEU   N C   1 
ATOM   2357 O O   . LEU   B 2 51  ? 140.764 152.420 198.834 1.00 158.71 ? 13  LEU   N O   1 
ATOM   2358 C CB  . LEU   B 2 51  ? 143.481 153.733 198.758 1.00 158.35 ? 13  LEU   N CB  1 
ATOM   2359 N N   . VAL   B 2 52  ? 142.047 150.572 198.999 1.00 164.34 ? 14  VAL   N N   1 
ATOM   2360 C CA  . VAL   B 2 52  ? 141.024 149.758 199.640 1.00 164.32 ? 14  VAL   N CA  1 
ATOM   2361 C C   . VAL   B 2 52  ? 141.629 149.096 200.870 1.00 164.26 ? 14  VAL   N C   1 
ATOM   2362 O O   . VAL   B 2 52  ? 142.844 148.887 200.954 1.00 164.26 ? 14  VAL   N O   1 
ATOM   2363 C CB  . VAL   B 2 52  ? 140.444 148.703 198.668 1.00 163.44 ? 14  VAL   N CB  1 
ATOM   2364 C CG1 . VAL   B 2 52  ? 141.463 147.608 198.386 1.00 162.83 ? 14  VAL   N CG1 1 
ATOM   2365 C CG2 . VAL   B 2 52  ? 139.136 148.125 199.199 1.00 163.09 ? 14  VAL   N CG2 1 
ATOM   2366 N N   . GLN   B 2 53  ? 140.772 148.782 201.838 1.00 164.63 ? 15  GLN   N N   1 
ATOM   2367 C CA  . GLN   B 2 53  ? 141.218 148.109 203.049 1.00 164.38 ? 15  GLN   N CA  1 
ATOM   2368 C C   . GLN   B 2 53  ? 141.678 146.689 202.736 1.00 164.31 ? 15  GLN   N C   1 
ATOM   2369 O O   . GLN   B 2 53  ? 141.202 146.049 201.794 1.00 164.14 ? 15  GLN   N O   1 
ATOM   2370 C CB  . GLN   B 2 53  ? 140.097 148.082 204.088 1.00 163.80 ? 15  GLN   N CB  1 
ATOM   2371 N N   . ALA   B 2 54  ? 142.620 146.202 203.540 1.00 162.45 ? 16  ALA   N N   1 
ATOM   2372 C CA  . ALA   B 2 54  ? 143.163 144.866 203.339 1.00 162.40 ? 16  ALA   N CA  1 
ATOM   2373 C C   . ALA   B 2 54  ? 142.092 143.806 203.563 1.00 162.58 ? 16  ALA   N C   1 
ATOM   2374 O O   . ALA   B 2 54  ? 141.232 143.941 204.437 1.00 163.11 ? 16  ALA   N O   1 
ATOM   2375 C CB  . ALA   B 2 54  ? 144.343 144.626 204.280 1.00 162.19 ? 16  ALA   N CB  1 
ATOM   2376 N N   . GLY   B 2 55  ? 142.149 142.745 202.761 1.00 157.64 ? 17  GLY   N N   1 
ATOM   2377 C CA  . GLY   B 2 55  ? 141.198 141.660 202.872 1.00 157.56 ? 17  GLY   N CA  1 
ATOM   2378 C C   . GLY   B 2 55  ? 139.881 141.881 202.166 1.00 158.37 ? 17  GLY   N C   1 
ATOM   2379 O O   . GLY   B 2 55  ? 138.982 141.042 202.291 1.00 158.10 ? 17  GLY   N O   1 
ATOM   2380 N N   . GLU   B 2 56  ? 139.735 142.980 201.430 1.00 157.03 ? 18  GLU   N N   1 
ATOM   2381 C CA  . GLU   B 2 56  ? 138.499 143.265 200.714 1.00 156.42 ? 18  GLU   N CA  1 
ATOM   2382 C C   . GLU   B 2 56  ? 138.552 142.626 199.327 1.00 155.47 ? 18  GLU   N C   1 
ATOM   2383 O O   . GLU   B 2 56  ? 139.517 141.948 198.960 1.00 154.47 ? 18  GLU   N O   1 
ATOM   2384 C CB  . GLU   B 2 56  ? 138.266 144.772 200.645 1.00 156.18 ? 18  GLU   N CB  1 
ATOM   2385 C CG  . GLU   B 2 56  ? 137.394 145.319 201.764 1.00 155.67 ? 18  GLU   N CG  1 
ATOM   2386 C CD  . GLU   B 2 56  ? 135.936 144.924 201.614 1.00 155.78 ? 18  GLU   N CD  1 
ATOM   2387 O OE1 . GLU   B 2 56  ? 135.497 144.688 200.469 1.00 156.34 ? 18  GLU   N OE1 1 
ATOM   2388 O OE2 . GLU   B 2 56  ? 135.229 144.851 202.641 1.00 155.70 ? 18  GLU   N OE2 1 
ATOM   2389 N N   . SER   B 2 57  ? 137.505 142.839 198.536 1.00 147.20 ? 19  SER   N N   1 
ATOM   2390 C CA  . SER   B 2 57  ? 137.403 142.295 197.189 1.00 147.05 ? 19  SER   N CA  1 
ATOM   2391 C C   . SER   B 2 57  ? 137.163 143.427 196.200 1.00 147.55 ? 19  SER   N C   1 
ATOM   2392 O O   . SER   B 2 57  ? 136.395 144.352 196.482 1.00 148.17 ? 19  SER   N O   1 
ATOM   2393 C CB  . SER   B 2 57  ? 136.277 141.263 197.096 1.00 147.19 ? 19  SER   N CB  1 
ATOM   2394 O OG  . SER   B 2 57  ? 136.553 140.131 197.902 1.00 147.60 ? 19  SER   N OG  1 
ATOM   2395 N N   . LEU   B 2 58  ? 137.821 143.348 195.046 1.00 137.62 ? 20  LEU   N N   1 
ATOM   2396 C CA  . LEU   B 2 58  ? 137.674 144.330 193.985 1.00 136.71 ? 20  LEU   N CA  1 
ATOM   2397 C C   . LEU   B 2 58  ? 137.347 143.616 192.682 1.00 135.23 ? 20  LEU   N C   1 
ATOM   2398 O O   . LEU   B 2 58  ? 137.400 142.387 192.592 1.00 134.87 ? 20  LEU   N O   1 
ATOM   2399 C CB  . LEU   B 2 58  ? 138.942 145.178 193.813 1.00 137.17 ? 20  LEU   N CB  1 
ATOM   2400 C CG  . LEU   B 2 58  ? 138.995 146.506 194.568 1.00 137.56 ? 20  LEU   N CG  1 
ATOM   2401 C CD1 . LEU   B 2 58  ? 140.358 147.159 194.399 1.00 136.52 ? 20  LEU   N CD1 1 
ATOM   2402 C CD2 . LEU   B 2 58  ? 137.888 147.437 194.097 1.00 136.51 ? 20  LEU   N CD2 1 
ATOM   2403 N N   . ARG   B 2 59  ? 136.998 144.406 191.668 1.00 125.10 ? 21  ARG   N N   1 
ATOM   2404 C CA  . ARG   B 2 59  ? 136.676 143.858 190.352 1.00 125.66 ? 21  ARG   N CA  1 
ATOM   2405 C C   . ARG   B 2 59  ? 137.109 144.881 189.306 1.00 125.37 ? 21  ARG   N C   1 
ATOM   2406 O O   . ARG   B 2 59  ? 136.389 145.851 189.049 1.00 124.52 ? 21  ARG   N O   1 
ATOM   2407 C CB  . ARG   B 2 59  ? 135.193 143.534 190.239 1.00 126.05 ? 21  ARG   N CB  1 
ATOM   2408 C CG  . ARG   B 2 59  ? 134.881 142.379 189.306 1.00 125.75 ? 21  ARG   N CG  1 
ATOM   2409 C CD  . ARG   B 2 59  ? 133.414 142.376 188.914 1.00 126.90 ? 21  ARG   N CD  1 
ATOM   2410 N NE  . ARG   B 2 59  ? 132.929 141.035 188.611 1.00 126.66 ? 21  ARG   N NE  1 
ATOM   2411 C CZ  . ARG   B 2 59  ? 131.785 140.777 187.993 1.00 126.79 ? 21  ARG   N CZ  1 
ATOM   2412 N NH1 . ARG   B 2 59  ? 130.983 141.748 187.590 1.00 127.17 ? 21  ARG   N NH1 1 
ATOM   2413 N NH2 . ARG   B 2 59  ? 131.439 139.512 187.771 1.00 125.02 ? 21  ARG   N NH2 1 
ATOM   2414 N N   . LEU   B 2 60  ? 138.280 144.662 188.716 1.00 118.66 ? 22  LEU   N N   1 
ATOM   2415 C CA  . LEU   B 2 60  ? 138.744 145.521 187.639 1.00 117.81 ? 22  LEU   N CA  1 
ATOM   2416 C C   . LEU   B 2 60  ? 137.868 145.350 186.404 1.00 116.79 ? 22  LEU   N C   1 
ATOM   2417 O O   . LEU   B 2 60  ? 137.308 144.280 186.153 1.00 117.98 ? 22  LEU   N O   1 
ATOM   2418 C CB  . LEU   B 2 60  ? 140.201 145.210 187.295 1.00 118.88 ? 22  LEU   N CB  1 
ATOM   2419 C CG  . LEU   B 2 60  ? 141.220 145.287 188.433 1.00 117.99 ? 22  LEU   N CG  1 
ATOM   2420 C CD1 . LEU   B 2 60  ? 142.606 144.902 187.939 1.00 116.69 ? 22  LEU   N CD1 1 
ATOM   2421 C CD2 . LEU   B 2 60  ? 141.234 146.680 189.040 1.00 118.49 ? 22  LEU   N CD2 1 
ATOM   2422 N N   . SER   B 2 61  ? 137.747 146.425 185.631 1.00 111.93 ? 23  SER   N N   1 
ATOM   2423 C CA  . SER   B 2 61  ? 136.966 146.422 184.405 1.00 112.31 ? 23  SER   N CA  1 
ATOM   2424 C C   . SER   B 2 61  ? 137.811 146.970 183.266 1.00 112.53 ? 23  SER   N C   1 
ATOM   2425 O O   . SER   B 2 61  ? 138.723 147.774 183.478 1.00 114.84 ? 23  SER   N O   1 
ATOM   2426 C CB  . SER   B 2 61  ? 135.682 147.250 184.549 1.00 113.88 ? 23  SER   N CB  1 
ATOM   2427 O OG  . SER   B 2 61  ? 135.975 148.633 184.644 1.00 115.55 ? 23  SER   N OG  1 
ATOM   2428 N N   . CYS   B 2 62  ? 137.503 146.519 182.050 1.00 101.84 ? 24  CYS   N N   1 
ATOM   2429 C CA  . CYS   B 2 62  ? 138.249 146.946 180.868 1.00 102.64 ? 24  CYS   N CA  1 
ATOM   2430 C C   . CYS   B 2 62  ? 137.324 146.795 179.664 1.00 102.47 ? 24  CYS   N C   1 
ATOM   2431 O O   . CYS   B 2 62  ? 137.146 145.688 179.151 1.00 104.01 ? 24  CYS   N O   1 
ATOM   2432 C CB  . CYS   B 2 62  ? 139.522 146.128 180.711 1.00 105.07 ? 24  CYS   N CB  1 
ATOM   2433 S SG  . CYS   B 2 62  ? 140.590 146.592 179.341 1.00 107.53 ? 24  CYS   N SG  1 
ATOM   2434 N N   . ALA   B 2 63  ? 136.742 147.907 179.224 1.00 97.35  ? 25  ALA   N N   1 
ATOM   2435 C CA  . ALA   B 2 63  ? 135.797 147.916 178.116 1.00 97.60  ? 25  ALA   N CA  1 
ATOM   2436 C C   . ALA   B 2 63  ? 136.438 148.568 176.900 1.00 98.24  ? 25  ALA   N C   1 
ATOM   2437 O O   . ALA   B 2 63  ? 137.025 149.650 177.006 1.00 99.32  ? 25  ALA   N O   1 
ATOM   2438 C CB  . ALA   B 2 63  ? 134.514 148.654 178.498 1.00 97.68  ? 25  ALA   N CB  1 
ATOM   2439 N N   . ALA   B 2 64  ? 136.319 147.914 175.749 1.00 89.22  ? 26  ALA   N N   1 
ATOM   2440 C CA  . ALA   B 2 64  ? 136.913 148.386 174.507 1.00 87.47  ? 26  ALA   N CA  1 
ATOM   2441 C C   . ALA   B 2 64  ? 135.819 148.895 173.581 1.00 89.10  ? 26  ALA   N C   1 
ATOM   2442 O O   . ALA   B 2 64  ? 134.796 148.230 173.397 1.00 89.80  ? 26  ALA   N O   1 
ATOM   2443 C CB  . ALA   B 2 64  ? 137.711 147.275 173.824 1.00 88.77  ? 26  ALA   N CB  1 
ATOM   2444 N N   . SER   B 2 65  ? 136.036 150.075 173.006 1.00 90.44  ? 27  SER   N N   1 
ATOM   2445 C CA  . SER   B 2 65  ? 135.078 150.675 172.090 1.00 90.46  ? 27  SER   N CA  1 
ATOM   2446 C C   . SER   B 2 65  ? 135.814 151.215 170.873 1.00 89.71  ? 27  SER   N C   1 
ATOM   2447 O O   . SER   B 2 65  ? 136.964 151.651 170.967 1.00 89.64  ? 27  SER   N O   1 
ATOM   2448 C CB  . SER   B 2 65  ? 134.278 151.798 172.765 1.00 89.13  ? 27  SER   N CB  1 
ATOM   2449 N N   . GLY   B 2 66  ? 135.133 151.184 169.728 1.00 78.94  ? 28  GLY   N N   1 
ATOM   2450 C CA  . GLY   B 2 66  ? 135.676 151.645 168.472 1.00 76.92  ? 28  GLY   N CA  1 
ATOM   2451 C C   . GLY   B 2 66  ? 135.344 150.673 167.363 1.00 77.87  ? 28  GLY   N C   1 
ATOM   2452 O O   . GLY   B 2 66  ? 134.387 149.896 167.455 1.00 77.91  ? 28  GLY   N O   1 
ATOM   2453 N N   . THR   B 2 67  ? 136.148 150.719 166.301 1.00 78.64  ? 29  THR   N N   1 
ATOM   2454 C CA  . THR   B 2 67  ? 135.973 149.830 165.152 1.00 78.55  ? 29  THR   N CA  1 
ATOM   2455 C C   . THR   B 2 67  ? 136.506 148.451 165.524 1.00 77.84  ? 29  THR   N C   1 
ATOM   2456 O O   . THR   B 2 67  ? 137.665 148.104 165.286 1.00 79.90  ? 29  THR   N O   1 
ATOM   2457 C CB  . THR   B 2 67  ? 136.676 150.388 163.922 1.00 78.98  ? 29  THR   N CB  1 
ATOM   2458 O OG1 . THR   B 2 67  ? 138.069 150.566 164.207 1.00 80.27  ? 29  THR   N OG1 1 
ATOM   2459 C CG2 . THR   B 2 67  ? 136.070 151.724 163.522 1.00 78.92  ? 29  THR   N CG2 1 
ATOM   2460 N N   . ILE   B 2 68  ? 135.632 147.650 166.125 1.00 71.66  ? 30  ILE   N N   1 
ATOM   2461 C CA  . ILE   B 2 68  ? 135.962 146.296 166.553 1.00 68.51  ? 30  ILE   N CA  1 
ATOM   2462 C C   . ILE   B 2 68  ? 135.151 145.325 165.711 1.00 69.92  ? 30  ILE   N C   1 
ATOM   2463 O O   . ILE   B 2 68  ? 133.916 145.385 165.695 1.00 74.11  ? 30  ILE   N O   1 
ATOM   2464 C CB  . ILE   B 2 68  ? 135.686 146.089 168.049 1.00 69.89  ? 30  ILE   N CB  1 
ATOM   2465 C CG1 . ILE   B 2 68  ? 136.732 146.818 168.891 1.00 72.89  ? 30  ILE   N CG1 1 
ATOM   2466 C CG2 . ILE   B 2 68  ? 135.669 144.610 168.385 1.00 69.39  ? 30  ILE   N CG2 1 
ATOM   2467 C CD1 . ILE   B 2 68  ? 136.445 146.798 170.374 1.00 72.85  ? 30  ILE   N CD1 1 
ATOM   2468 N N   . PHE   B 2 69  ? 135.847 144.431 165.010 1.00 61.12  ? 31  PHE   N N   1 
ATOM   2469 C CA  . PHE   B 2 69  ? 135.199 143.371 164.251 1.00 56.65  ? 31  PHE   N CA  1 
ATOM   2470 C C   . PHE   B 2 69  ? 135.162 142.063 165.031 1.00 61.22  ? 31  PHE   N C   1 
ATOM   2471 O O   . PHE   B 2 69  ? 134.134 141.379 165.040 1.00 63.49  ? 31  PHE   N O   1 
ATOM   2472 C CB  . PHE   B 2 69  ? 135.914 143.182 162.911 1.00 57.21  ? 31  PHE   N CB  1 
ATOM   2473 C CG  . PHE   B 2 69  ? 135.781 141.803 162.335 1.00 61.09  ? 31  PHE   N CG  1 
ATOM   2474 C CD1 . PHE   B 2 69  ? 134.592 141.388 161.765 1.00 63.21  ? 31  PHE   N CD1 1 
ATOM   2475 C CD2 . PHE   B 2 69  ? 136.854 140.929 162.346 1.00 60.32  ? 31  PHE   N CD2 1 
ATOM   2476 C CE1 . PHE   B 2 69  ? 134.472 140.123 161.232 1.00 63.76  ? 31  PHE   N CE1 1 
ATOM   2477 C CE2 . PHE   B 2 69  ? 136.738 139.664 161.814 1.00 58.61  ? 31  PHE   N CE2 1 
ATOM   2478 C CZ  . PHE   B 2 69  ? 135.545 139.261 161.256 1.00 61.30  ? 31  PHE   N CZ  1 
ATOM   2479 N N   . ARG   B 2 70  ? 136.262 141.711 165.695 1.00 66.27  ? 32  ARG   N N   1 
ATOM   2480 C CA  . ARG   B 2 70  ? 136.321 140.550 166.572 1.00 64.60  ? 32  ARG   N CA  1 
ATOM   2481 C C   . ARG   B 2 70  ? 137.482 140.723 167.540 1.00 62.37  ? 32  ARG   N C   1 
ATOM   2482 O O   . ARG   B 2 70  ? 138.503 141.319 167.189 1.00 63.44  ? 32  ARG   N O   1 
ATOM   2483 C CB  . ARG   B 2 70  ? 136.482 139.249 165.775 1.00 62.96  ? 32  ARG   N CB  1 
ATOM   2484 C CG  . ARG   B 2 70  ? 135.194 138.454 165.621 1.00 62.45  ? 32  ARG   N CG  1 
ATOM   2485 C CD  . ARG   B 2 70  ? 135.447 136.959 165.683 1.00 61.31  ? 32  ARG   N CD  1 
ATOM   2486 N NE  . ARG   B 2 70  ? 136.235 136.584 166.852 1.00 65.64  ? 32  ARG   N NE  1 
ATOM   2487 C CZ  . ARG   B 2 70  ? 136.560 135.339 167.167 1.00 65.37  ? 32  ARG   N CZ  1 
ATOM   2488 N NH1 . ARG   B 2 70  ? 136.171 134.314 166.427 1.00 63.69  ? 32  ARG   N NH1 1 
ATOM   2489 N NH2 . ARG   B 2 70  ? 137.293 135.115 168.254 1.00 63.69  ? 32  ARG   N NH2 1 
ATOM   2490 N N   . LEU   B 2 71  ? 137.314 140.203 168.753 1.00 62.25  ? 33  LEU   N N   1 
ATOM   2491 C CA  . LEU   B 2 71  ? 138.341 140.218 169.787 1.00 63.78  ? 33  LEU   N CA  1 
ATOM   2492 C C   . LEU   B 2 71  ? 138.760 138.788 170.091 1.00 67.27  ? 33  LEU   N C   1 
ATOM   2493 O O   . LEU   B 2 71  ? 137.908 137.904 170.226 1.00 70.88  ? 33  LEU   N O   1 
ATOM   2494 C CB  . LEU   B 2 71  ? 137.829 140.902 171.054 1.00 69.20  ? 33  LEU   N CB  1 
ATOM   2495 C CG  . LEU   B 2 71  ? 137.761 142.425 171.008 1.00 72.03  ? 33  LEU   N CG  1 
ATOM   2496 C CD1 . LEU   B 2 71  ? 136.749 142.923 172.005 1.00 70.01  ? 33  LEU   N CD1 1 
ATOM   2497 C CD2 . LEU   B 2 71  ? 139.124 143.002 171.325 1.00 71.05  ? 33  LEU   N CD2 1 
ATOM   2498 N N   . TYR   B 2 72  ? 140.069 138.562 170.200 1.00 61.30  ? 34  TYR   N N   1 
ATOM   2499 C CA  . TYR   B 2 72  ? 140.607 137.210 170.286 1.00 63.37  ? 34  TYR   N CA  1 
ATOM   2500 C C   . TYR   B 2 72  ? 141.105 136.859 171.684 1.00 64.75  ? 34  TYR   N C   1 
ATOM   2501 O O   . TYR   B 2 72  ? 140.665 135.866 172.268 1.00 69.66  ? 34  TYR   N O   1 
ATOM   2502 C CB  . TYR   B 2 72  ? 141.723 137.041 169.249 1.00 62.85  ? 34  TYR   N CB  1 
ATOM   2503 C CG  . TYR   B 2 72  ? 141.222 137.173 167.830 1.00 60.89  ? 34  TYR   N CG  1 
ATOM   2504 C CD1 . TYR   B 2 72  ? 140.384 136.216 167.280 1.00 59.73  ? 34  TYR   N CD1 1 
ATOM   2505 C CD2 . TYR   B 2 72  ? 141.573 138.261 167.047 1.00 62.59  ? 34  TYR   N CD2 1 
ATOM   2506 C CE1 . TYR   B 2 72  ? 139.918 136.334 165.990 1.00 62.66  ? 34  TYR   N CE1 1 
ATOM   2507 C CE2 . TYR   B 2 72  ? 141.113 138.387 165.754 1.00 60.69  ? 34  TYR   N CE2 1 
ATOM   2508 C CZ  . TYR   B 2 72  ? 140.286 137.421 165.231 1.00 61.64  ? 34  TYR   N CZ  1 
ATOM   2509 O OH  . TYR   B 2 72  ? 139.824 137.540 163.942 1.00 66.61  ? 34  TYR   N OH  1 
ATOM   2510 N N   . ASP   B 2 73  ? 142.013 137.656 172.236 1.00 72.29  ? 35  ASP   N N   1 
ATOM   2511 C CA  . ASP   B 2 73  ? 142.595 137.376 173.540 1.00 73.04  ? 35  ASP   N CA  1 
ATOM   2512 C C   . ASP   B 2 73  ? 142.517 138.610 174.423 1.00 74.43  ? 35  ASP   N C   1 
ATOM   2513 O O   . ASP   B 2 73  ? 142.638 139.739 173.940 1.00 82.72  ? 35  ASP   N O   1 
ATOM   2514 C CB  . ASP   B 2 73  ? 144.055 136.928 173.415 1.00 75.50  ? 35  ASP   N CB  1 
ATOM   2515 C CG  . ASP   B 2 73  ? 144.191 135.437 173.199 1.00 78.35  ? 35  ASP   N CG  1 
ATOM   2516 O OD1 . ASP   B 2 73  ? 143.194 134.798 172.810 1.00 81.15  ? 35  ASP   N OD1 1 
ATOM   2517 O OD2 . ASP   B 2 73  ? 145.298 134.902 173.418 1.00 79.41  ? 35  ASP   N OD2 1 
ATOM   2518 N N   . MET   B 2 74  ? 142.307 138.387 175.716 1.00 74.72  ? 36  MET   N N   1 
ATOM   2519 C CA  . MET   B 2 74  ? 142.379 139.430 176.728 1.00 77.40  ? 36  MET   N CA  1 
ATOM   2520 C C   . MET   B 2 74  ? 143.199 138.923 177.901 1.00 79.64  ? 36  MET   N C   1 
ATOM   2521 O O   . MET   B 2 74  ? 143.262 137.716 178.148 1.00 87.16  ? 36  MET   N O   1 
ATOM   2522 C CB  . MET   B 2 74  ? 140.992 139.853 177.218 1.00 79.92  ? 36  MET   N CB  1 
ATOM   2523 C CG  . MET   B 2 74  ? 140.030 140.271 176.128 1.00 80.70  ? 36  MET   N CG  1 
ATOM   2524 S SD  . MET   B 2 74  ? 139.204 141.809 176.574 1.00 84.22  ? 36  MET   N SD  1 
ATOM   2525 C CE  . MET   B 2 74  ? 138.543 142.307 174.993 1.00 82.44  ? 36  MET   N CE  1 
ATOM   2526 N N   . GLY   B 2 75  ? 143.828 139.843 178.619 1.00 79.79  ? 37  GLY   N N   1 
ATOM   2527 C CA  . GLY   B 2 75  ? 144.589 139.460 179.789 1.00 81.66  ? 37  GLY   N CA  1 
ATOM   2528 C C   . GLY   B 2 75  ? 145.162 140.668 180.488 1.00 83.31  ? 37  GLY   N C   1 
ATOM   2529 O O   . GLY   B 2 75  ? 145.313 141.742 179.897 1.00 87.86  ? 37  GLY   N O   1 
ATOM   2530 N N   . TRP   B 2 76  ? 145.484 140.474 181.761 1.00 100.70 ? 38  TRP   N N   1 
ATOM   2531 C CA  . TRP   B 2 76  ? 146.131 141.492 182.572 1.00 101.16 ? 38  TRP   N CA  1 
ATOM   2532 C C   . TRP   B 2 76  ? 147.604 141.148 182.723 1.00 101.82 ? 38  TRP   N C   1 
ATOM   2533 O O   . TRP   B 2 76  ? 147.955 140.018 183.070 1.00 104.84 ? 38  TRP   N O   1 
ATOM   2534 C CB  . TRP   B 2 76  ? 145.468 141.600 183.945 1.00 102.51 ? 38  TRP   N CB  1 
ATOM   2535 C CG  . TRP   B 2 76  ? 144.061 142.098 183.874 1.00 105.81 ? 38  TRP   N CG  1 
ATOM   2536 C CD1 . TRP   B 2 76  ? 142.945 141.363 183.608 1.00 105.49 ? 38  TRP   N CD1 1 
ATOM   2537 C CD2 . TRP   B 2 76  ? 143.618 143.447 184.063 1.00 105.61 ? 38  TRP   N CD2 1 
ATOM   2538 N NE1 . TRP   B 2 76  ? 141.833 142.169 183.622 1.00 106.40 ? 38  TRP   N NE1 1 
ATOM   2539 C CE2 . TRP   B 2 76  ? 142.221 143.453 183.899 1.00 105.40 ? 38  TRP   N CE2 1 
ATOM   2540 C CE3 . TRP   B 2 76  ? 144.268 144.649 184.354 1.00 104.13 ? 38  TRP   N CE3 1 
ATOM   2541 C CZ2 . TRP   B 2 76  ? 141.462 144.613 184.019 1.00 103.78 ? 38  TRP   N CZ2 1 
ATOM   2542 C CZ3 . TRP   B 2 76  ? 143.514 145.799 184.473 1.00 103.35 ? 38  TRP   N CZ3 1 
ATOM   2543 C CH2 . TRP   B 2 76  ? 142.126 145.773 184.306 1.00 103.29 ? 38  TRP   N CH2 1 
ATOM   2544 N N   . TYR   B 2 77  ? 148.463 142.125 182.456 1.00 106.72 ? 39  TYR   N N   1 
ATOM   2545 C CA  . TYR   B 2 77  ? 149.899 141.902 182.427 1.00 108.01 ? 39  TYR   N CA  1 
ATOM   2546 C C   . TYR   B 2 77  ? 150.582 142.785 183.460 1.00 110.09 ? 39  TYR   N C   1 
ATOM   2547 O O   . TYR   B 2 77  ? 150.138 143.901 183.741 1.00 111.07 ? 39  TYR   N O   1 
ATOM   2548 C CB  . TYR   B 2 77  ? 150.481 142.177 181.034 1.00 109.21 ? 39  TYR   N CB  1 
ATOM   2549 C CG  . TYR   B 2 77  ? 150.174 141.100 180.018 1.00 109.01 ? 39  TYR   N CG  1 
ATOM   2550 C CD1 . TYR   B 2 77  ? 148.871 140.856 179.607 1.00 109.03 ? 39  TYR   N CD1 1 
ATOM   2551 C CD2 . TYR   B 2 77  ? 151.188 140.328 179.468 1.00 108.91 ? 39  TYR   N CD2 1 
ATOM   2552 C CE1 . TYR   B 2 77  ? 148.586 139.874 178.681 1.00 109.78 ? 39  TYR   N CE1 1 
ATOM   2553 C CE2 . TYR   B 2 77  ? 150.912 139.345 178.538 1.00 109.12 ? 39  TYR   N CE2 1 
ATOM   2554 C CZ  . TYR   B 2 77  ? 149.608 139.122 178.150 1.00 109.62 ? 39  TYR   N CZ  1 
ATOM   2555 O OH  . TYR   B 2 77  ? 149.324 138.143 177.226 1.00 109.20 ? 39  TYR   N OH  1 
ATOM   2556 N N   . ARG   B 2 78  ? 151.666 142.267 184.024 1.00 118.56 ? 40  ARG   N N   1 
ATOM   2557 C CA  . ARG   B 2 78  ? 152.437 142.996 185.021 1.00 118.99 ? 40  ARG   N CA  1 
ATOM   2558 C C   . ARG   B 2 78  ? 153.914 142.625 184.938 1.00 119.51 ? 40  ARG   N C   1 
ATOM   2559 O O   . ARG   B 2 78  ? 154.263 141.490 184.614 1.00 119.69 ? 40  ARG   N O   1 
ATOM   2560 C CB  . ARG   B 2 78  ? 151.897 142.715 186.423 1.00 118.41 ? 40  ARG   N CB  1 
ATOM   2561 C CG  . ARG   B 2 78  ? 152.876 143.032 187.539 1.00 118.74 ? 40  ARG   N CG  1 
ATOM   2562 C CD  . ARG   B 2 78  ? 153.119 144.526 187.652 1.00 119.91 ? 40  ARG   N CD  1 
ATOM   2563 N NE  . ARG   B 2 78  ? 154.429 144.909 187.141 1.00 120.22 ? 40  ARG   N NE  1 
ATOM   2564 C CZ  . ARG   B 2 78  ? 154.850 146.161 187.028 1.00 119.66 ? 40  ARG   N CZ  1 
ATOM   2565 N NH1 . ARG   B 2 78  ? 154.087 147.181 187.386 1.00 118.26 ? 40  ARG   N NH1 1 
ATOM   2566 N NH2 . ARG   B 2 78  ? 156.066 146.395 186.544 1.00 119.83 ? 40  ARG   N NH2 1 
ATOM   2567 N N   . GLN   B 2 84  ? 160.388 141.940 181.028 1.00 132.55 ? 46  GLN   N N   1 
ATOM   2568 C CA  . GLN   B 2 84  ? 159.278 141.125 180.548 1.00 133.22 ? 46  GLN   N CA  1 
ATOM   2569 C C   . GLN   B 2 84  ? 158.025 141.349 181.387 1.00 133.46 ? 46  GLN   N C   1 
ATOM   2570 O O   . GLN   B 2 84  ? 158.094 141.450 182.612 1.00 132.34 ? 46  GLN   N O   1 
ATOM   2571 C CB  . GLN   B 2 84  ? 159.657 139.642 180.558 1.00 132.81 ? 46  GLN   N CB  1 
ATOM   2572 C CG  . GLN   B 2 84  ? 160.145 139.116 179.217 1.00 132.72 ? 46  GLN   N CG  1 
ATOM   2573 C CD  . GLN   B 2 84  ? 159.006 138.798 178.269 1.00 133.25 ? 46  GLN   N CD  1 
ATOM   2574 O OE1 . GLN   B 2 84  ? 157.850 138.704 178.680 1.00 133.30 ? 46  GLN   N OE1 1 
ATOM   2575 N NE2 . GLN   B 2 84  ? 159.328 138.630 176.991 1.00 133.15 ? 46  GLN   N NE2 1 
ATOM   2576 N N   . ARG   B 2 85  ? 156.878 141.427 180.717 1.00 128.23 ? 47  ARG   N N   1 
ATOM   2577 C CA  . ARG   B 2 85  ? 155.585 141.615 181.374 1.00 127.38 ? 47  ARG   N CA  1 
ATOM   2578 C C   . ARG   B 2 85  ? 154.901 140.255 181.454 1.00 126.10 ? 47  ARG   N C   1 
ATOM   2579 O O   . ARG   B 2 85  ? 154.297 139.782 180.491 1.00 124.95 ? 47  ARG   N O   1 
ATOM   2580 C CB  . ARG   B 2 85  ? 154.737 142.636 180.622 1.00 125.45 ? 47  ARG   N CB  1 
ATOM   2581 C CG  . ARG   B 2 85  ? 154.652 143.989 181.305 1.00 123.55 ? 47  ARG   N CG  1 
ATOM   2582 C CD  . ARG   B 2 85  ? 156.011 144.444 181.801 1.00 124.87 ? 47  ARG   N CD  1 
ATOM   2583 N NE  . ARG   B 2 85  ? 155.943 145.738 182.469 1.00 125.65 ? 47  ARG   N NE  1 
ATOM   2584 C CZ  . ARG   B 2 85  ? 156.973 146.331 183.057 1.00 125.67 ? 47  ARG   N CZ  1 
ATOM   2585 N NH1 . ARG   B 2 85  ? 158.171 145.769 183.084 1.00 125.36 ? 47  ARG   N NH1 1 
ATOM   2586 N NH2 . ARG   B 2 85  ? 156.797 147.516 183.634 1.00 124.95 ? 47  ARG   N NH2 1 
ATOM   2587 N N   . GLU   B 2 86  ? 155.006 139.620 182.619 1.00 125.01 ? 48  GLU   N N   1 
ATOM   2588 C CA  . GLU   B 2 86  ? 154.409 138.307 182.811 1.00 125.59 ? 48  GLU   N CA  1 
ATOM   2589 C C   . GLU   B 2 86  ? 152.890 138.405 182.818 1.00 125.99 ? 48  GLU   N C   1 
ATOM   2590 O O   . GLU   B 2 86  ? 152.307 139.267 183.482 1.00 125.09 ? 48  GLU   N O   1 
ATOM   2591 C CB  . GLU   B 2 86  ? 154.903 137.683 184.116 1.00 125.50 ? 48  GLU   N CB  1 
ATOM   2592 C CG  . GLU   B 2 86  ? 154.282 136.329 184.436 1.00 125.28 ? 48  GLU   N CG  1 
ATOM   2593 C CD  . GLU   B 2 86  ? 154.727 135.782 185.779 1.00 126.01 ? 48  GLU   N CD  1 
ATOM   2594 O OE1 . GLU   B 2 86  ? 155.522 136.459 186.465 1.00 125.92 ? 48  GLU   N OE1 1 
ATOM   2595 O OE2 . GLU   B 2 86  ? 154.281 134.675 186.150 1.00 126.45 ? 48  GLU   N OE2 1 
ATOM   2596 N N   . LEU   B 2 87  ? 152.248 137.509 182.073 1.00 118.95 ? 49  LEU   N N   1 
ATOM   2597 C CA  . LEU   B 2 87  ? 150.790 137.461 181.993 1.00 117.06 ? 49  LEU   N CA  1 
ATOM   2598 C C   . LEU   B 2 87  ? 150.268 136.833 183.276 1.00 116.24 ? 49  LEU   N C   1 
ATOM   2599 O O   . LEU   B 2 87  ? 150.156 135.612 183.398 1.00 116.90 ? 49  LEU   N O   1 
ATOM   2600 C CB  . LEU   B 2 87  ? 150.340 136.679 180.766 1.00 114.93 ? 49  LEU   N CB  1 
ATOM   2601 N N   . VAL   B 2 88  ? 149.949 137.684 184.254 1.00 107.05 ? 50  VAL   N N   1 
ATOM   2602 C CA  . VAL   B 2 88  ? 149.410 137.184 185.514 1.00 106.96 ? 50  VAL   N CA  1 
ATOM   2603 C C   . VAL   B 2 88  ? 148.047 136.538 185.294 1.00 107.26 ? 50  VAL   N C   1 
ATOM   2604 O O   . VAL   B 2 88  ? 147.629 135.673 186.074 1.00 108.94 ? 50  VAL   N O   1 
ATOM   2605 C CB  . VAL   B 2 88  ? 149.351 138.318 186.556 1.00 106.41 ? 50  VAL   N CB  1 
ATOM   2606 C CG1 . VAL   B 2 88  ? 148.260 139.318 186.210 1.00 107.65 ? 50  VAL   N CG1 1 
ATOM   2607 C CG2 . VAL   B 2 88  ? 149.151 137.752 187.954 1.00 107.57 ? 50  VAL   N CG2 1 
ATOM   2608 N N   . ALA   B 2 89  ? 147.340 136.931 184.238 1.00 93.76  ? 51  ALA   N N   1 
ATOM   2609 C CA  . ALA   B 2 89  ? 146.074 136.311 183.880 1.00 91.52  ? 51  ALA   N CA  1 
ATOM   2610 C C   . ALA   B 2 89  ? 145.833 136.531 182.396 1.00 93.65  ? 51  ALA   N C   1 
ATOM   2611 O O   . ALA   B 2 89  ? 146.265 137.538 181.829 1.00 99.49  ? 51  ALA   N O   1 
ATOM   2612 C CB  . ALA   B 2 89  ? 144.913 136.875 184.705 1.00 92.14  ? 51  ALA   N CB  1 
ATOM   2613 N N   . SER   B 2 90  ? 145.142 135.580 181.773 1.00 83.60  ? 52  SER   N N   1 
ATOM   2614 C CA  . SER   B 2 90  ? 144.848 135.665 180.345 1.00 83.37  ? 52  SER   N CA  1 
ATOM   2615 C C   . SER   B 2 90  ? 143.738 134.681 180.021 1.00 83.45  ? 52  SER   N C   1 
ATOM   2616 O O   . SER   B 2 90  ? 143.845 133.498 180.358 1.00 85.83  ? 52  SER   N O   1 
ATOM   2617 C CB  . SER   B 2 90  ? 146.094 135.371 179.510 1.00 83.46  ? 52  SER   N CB  1 
ATOM   2618 N N   . ILE   B 2 91  ? 142.681 135.161 179.374 1.00 86.81  ? 53  ILE   N N   1 
ATOM   2619 C CA  . ILE   B 2 91  ? 141.551 134.335 178.972 1.00 87.03  ? 53  ILE   N CA  1 
ATOM   2620 C C   . ILE   B 2 91  ? 141.338 134.509 177.476 1.00 88.64  ? 53  ILE   N C   1 
ATOM   2621 O O   . ILE   B 2 91  ? 141.284 135.638 176.977 1.00 91.74  ? 53  ILE   N O   1 
ATOM   2622 C CB  . ILE   B 2 91  ? 140.277 134.693 179.762 1.00 90.68  ? 53  ILE   N CB  1 
ATOM   2623 C CG1 . ILE   B 2 91  ? 139.066 133.947 179.198 1.00 91.92  ? 53  ILE   N CG1 1 
ATOM   2624 C CG2 . ILE   B 2 91  ? 140.049 136.200 179.780 1.00 90.96  ? 53  ILE   N CG2 1 
ATOM   2625 C CD1 . ILE   B 2 91  ? 137.843 134.008 180.087 1.00 93.84  ? 53  ILE   N CD1 1 
ATOM   2626 N N   . THR   B 2 92  ? 141.231 133.393 176.761 1.00 86.12  ? 54  THR   N N   1 
ATOM   2627 C CA  . THR   B 2 92  ? 141.031 133.440 175.323 1.00 86.82  ? 54  THR   N CA  1 
ATOM   2628 C C   . THR   B 2 92  ? 139.555 133.667 175.008 1.00 87.45  ? 54  THR   N C   1 
ATOM   2629 O O   . THR   B 2 92  ? 138.716 133.819 175.900 1.00 88.91  ? 54  THR   N O   1 
ATOM   2630 C CB  . THR   B 2 92  ? 141.534 132.156 174.671 1.00 86.62  ? 54  THR   N CB  1 
ATOM   2631 O OG1 . THR   B 2 92  ? 140.594 131.101 174.905 1.00 88.21  ? 54  THR   N OG1 1 
ATOM   2632 C CG2 . THR   B 2 92  ? 142.879 131.760 175.255 1.00 86.30  ? 54  THR   N CG2 1 
ATOM   2633 N N   . SER   B 2 93  ? 139.231 133.697 173.715 1.00 84.07  ? 55  SER   N N   1 
ATOM   2634 C CA  . SER   B 2 93  ? 137.841 133.876 173.313 1.00 83.67  ? 55  SER   N CA  1 
ATOM   2635 C C   . SER   B 2 93  ? 136.984 132.686 173.721 1.00 84.59  ? 55  SER   N C   1 
ATOM   2636 O O   . SER   B 2 93  ? 135.786 132.847 173.980 1.00 85.03  ? 55  SER   N O   1 
ATOM   2637 C CB  . SER   B 2 93  ? 137.754 134.105 171.806 1.00 83.18  ? 55  SER   N CB  1 
ATOM   2638 O OG  . SER   B 2 93  ? 136.655 134.937 171.480 1.00 82.34  ? 55  SER   N OG  1 
ATOM   2639 N N   . GLY   B 2 94  ? 137.573 131.495 173.785 1.00 91.03  ? 56  GLY   N N   1 
ATOM   2640 C CA  . GLY   B 2 94  ? 136.883 130.296 174.207 1.00 90.48  ? 56  GLY   N CA  1 
ATOM   2641 C C   . GLY   B 2 94  ? 136.924 130.012 175.689 1.00 93.91  ? 56  GLY   N C   1 
ATOM   2642 O O   . GLY   B 2 94  ? 136.448 128.958 176.121 1.00 96.76  ? 56  GLY   N O   1 
ATOM   2643 N N   . GLY   B 2 95  ? 137.482 130.918 176.489 1.00 89.56  ? 57  GLY   N N   1 
ATOM   2644 C CA  . GLY   B 2 95  ? 137.543 130.729 177.923 1.00 86.32  ? 57  GLY   N CA  1 
ATOM   2645 C C   . GLY   B 2 95  ? 138.709 129.910 178.422 1.00 85.48  ? 57  GLY   N C   1 
ATOM   2646 O O   . GLY   B 2 95  ? 138.753 129.591 179.615 1.00 89.73  ? 57  GLY   N O   1 
ATOM   2647 N N   . SER   B 2 96  ? 139.658 129.559 177.555 1.00 86.73  ? 58  SER   N N   1 
ATOM   2648 C CA  . SER   B 2 96  ? 140.810 128.748 177.952 1.00 89.46  ? 58  SER   N CA  1 
ATOM   2649 C C   . SER   B 2 96  ? 141.793 129.635 178.712 1.00 92.18  ? 58  SER   N C   1 
ATOM   2650 O O   . SER   B 2 96  ? 142.803 130.107 178.184 1.00 93.17  ? 58  SER   N O   1 
ATOM   2651 C CB  . SER   B 2 96  ? 141.459 128.103 176.735 1.00 88.29  ? 58  SER   N CB  1 
ATOM   2652 N N   . THR   B 2 97  ? 141.484 129.857 179.986 1.00 97.78  ? 59  THR   N N   1 
ATOM   2653 C CA  . THR   B 2 97  ? 142.308 130.717 180.822 1.00 96.17  ? 59  THR   N CA  1 
ATOM   2654 C C   . THR   B 2 97  ? 143.655 130.065 181.115 1.00 95.70  ? 59  THR   N C   1 
ATOM   2655 O O   . THR   B 2 97  ? 143.773 128.840 181.203 1.00 95.77  ? 59  THR   N O   1 
ATOM   2656 C CB  . THR   B 2 97  ? 141.590 131.032 182.132 1.00 96.69  ? 59  THR   N CB  1 
ATOM   2657 O OG1 . THR   B 2 97  ? 141.554 129.857 182.950 1.00 96.22  ? 59  THR   N OG1 1 
ATOM   2658 C CG2 . THR   B 2 97  ? 140.165 131.486 181.860 1.00 96.46  ? 59  THR   N CG2 1 
ATOM   2659 N N   . LYS   B 2 98  ? 144.681 130.903 181.268 1.00 94.86  ? 60  LYS   N N   1 
ATOM   2660 C CA  . LYS   B 2 98  ? 146.044 130.461 181.574 1.00 95.70  ? 60  LYS   N CA  1 
ATOM   2661 C C   . LYS   B 2 98  ? 146.586 131.351 182.690 1.00 96.37  ? 60  LYS   N C   1 
ATOM   2662 O O   . LYS   B 2 98  ? 147.199 132.388 182.426 1.00 98.01  ? 60  LYS   N O   1 
ATOM   2663 C CB  . LYS   B 2 98  ? 146.930 130.511 180.331 1.00 93.19  ? 60  LYS   N CB  1 
ATOM   2664 N N   . TYR   B 2 99  ? 146.369 130.939 183.935 1.00 101.26 ? 61  TYR   N N   1 
ATOM   2665 C CA  . TYR   B 2 99  ? 146.753 131.747 185.082 1.00 102.35 ? 61  TYR   N CA  1 
ATOM   2666 C C   . TYR   B 2 99  ? 148.249 131.638 185.359 1.00 102.55 ? 61  TYR   N C   1 
ATOM   2667 O O   . TYR   B 2 99  ? 148.938 130.735 184.878 1.00 101.89 ? 61  TYR   N O   1 
ATOM   2668 C CB  . TYR   B 2 99  ? 145.969 131.329 186.326 1.00 101.91 ? 61  TYR   N CB  1 
ATOM   2669 C CG  . TYR   B 2 99  ? 144.529 131.784 186.324 1.00 101.05 ? 61  TYR   N CG  1 
ATOM   2670 C CD1 . TYR   B 2 99  ? 144.087 132.767 187.197 1.00 102.95 ? 61  TYR   N CD1 1 
ATOM   2671 C CD2 . TYR   B 2 99  ? 143.610 131.228 185.448 1.00 99.48  ? 61  TYR   N CD2 1 
ATOM   2672 C CE1 . TYR   B 2 99  ? 142.771 133.182 187.190 1.00 104.12 ? 61  TYR   N CE1 1 
ATOM   2673 C CE2 . TYR   B 2 99  ? 142.296 131.636 185.438 1.00 100.61 ? 61  TYR   N CE2 1 
ATOM   2674 C CZ  . TYR   B 2 99  ? 141.879 132.612 186.308 1.00 103.39 ? 61  TYR   N CZ  1 
ATOM   2675 O OH  . TYR   B 2 99  ? 140.564 133.013 186.291 1.00 104.62 ? 61  TYR   N OH  1 
ATOM   2676 N N   . GLY   B 2 100 ? 148.747 132.585 186.154 1.00 113.66 ? 62  GLY   N N   1 
ATOM   2677 C CA  . GLY   B 2 100 ? 150.121 132.529 186.595 1.00 114.34 ? 62  GLY   N CA  1 
ATOM   2678 C C   . GLY   B 2 100 ? 150.324 131.547 187.734 1.00 116.18 ? 62  GLY   N C   1 
ATOM   2679 O O   . GLY   B 2 100 ? 149.390 131.155 188.431 1.00 116.31 ? 62  GLY   N O   1 
ATOM   2680 N N   . ASP   B 2 101 ? 151.584 131.145 187.917 1.00 127.31 ? 63  ASP   N N   1 
ATOM   2681 C CA  . ASP   B 2 101 ? 151.907 130.185 188.968 1.00 127.41 ? 63  ASP   N CA  1 
ATOM   2682 C C   . ASP   B 2 101 ? 151.624 130.757 190.352 1.00 127.74 ? 63  ASP   N C   1 
ATOM   2683 O O   . ASP   B 2 101 ? 151.089 130.059 191.221 1.00 126.55 ? 63  ASP   N O   1 
ATOM   2684 C CB  . ASP   B 2 101 ? 153.370 129.756 188.853 1.00 126.73 ? 63  ASP   N CB  1 
ATOM   2685 N N   . SER   B 2 102 ? 151.967 132.023 190.573 1.00 127.38 ? 64  SER   N N   1 
ATOM   2686 C CA  . SER   B 2 102 ? 151.786 132.665 191.868 1.00 125.83 ? 64  SER   N CA  1 
ATOM   2687 C C   . SER   B 2 102 ? 150.407 133.288 192.039 1.00 125.84 ? 64  SER   N C   1 
ATOM   2688 O O   . SER   B 2 102 ? 150.137 133.878 193.090 1.00 124.90 ? 64  SER   N O   1 
ATOM   2689 C CB  . SER   B 2 102 ? 152.862 133.736 192.078 1.00 124.43 ? 64  SER   N CB  1 
ATOM   2690 N N   . VAL   B 2 103 ? 149.533 133.176 191.040 1.00 131.66 ? 65  VAL   N N   1 
ATOM   2691 C CA  . VAL   B 2 103 ? 148.195 133.747 191.099 1.00 131.28 ? 65  VAL   N CA  1 
ATOM   2692 C C   . VAL   B 2 103 ? 147.113 132.685 190.954 1.00 132.38 ? 65  VAL   N C   1 
ATOM   2693 O O   . VAL   B 2 103 ? 145.927 132.999 191.057 1.00 132.90 ? 65  VAL   N O   1 
ATOM   2694 C CB  . VAL   B 2 103 ? 148.016 134.853 190.040 1.00 130.16 ? 65  VAL   N CB  1 
ATOM   2695 N N   . LYS   B 2 104 ? 147.495 131.434 190.717 1.00 134.12 ? 66  LYS   N N   1 
ATOM   2696 C CA  . LYS   B 2 104 ? 146.514 130.378 190.513 1.00 133.24 ? 66  LYS   N CA  1 
ATOM   2697 C C   . LYS   B 2 104 ? 145.823 130.020 191.823 1.00 134.33 ? 66  LYS   N C   1 
ATOM   2698 O O   . LYS   B 2 104 ? 146.451 129.969 192.885 1.00 134.36 ? 66  LYS   N O   1 
ATOM   2699 C CB  . LYS   B 2 104 ? 147.181 129.140 189.917 1.00 131.80 ? 66  LYS   N CB  1 
ATOM   2700 N N   . GLY   B 2 105 ? 144.518 129.772 191.742 1.00 137.57 ? 67  GLY   N N   1 
ATOM   2701 C CA  . GLY   B 2 105 ? 143.749 129.375 192.902 1.00 137.22 ? 67  GLY   N CA  1 
ATOM   2702 C C   . GLY   B 2 105 ? 143.310 130.500 193.810 1.00 137.00 ? 67  GLY   N C   1 
ATOM   2703 O O   . GLY   B 2 105 ? 142.673 130.231 194.835 1.00 137.33 ? 67  GLY   N O   1 
ATOM   2704 N N   . ARG   B 2 106 ? 143.627 131.750 193.475 1.00 137.65 ? 68  ARG   N N   1 
ATOM   2705 C CA  . ARG   B 2 106 ? 143.232 132.879 194.309 1.00 137.67 ? 68  ARG   N CA  1 
ATOM   2706 C C   . ARG   B 2 106 ? 142.458 133.911 193.502 1.00 137.59 ? 68  ARG   N C   1 
ATOM   2707 O O   . ARG   B 2 106 ? 141.563 134.579 194.030 1.00 137.49 ? 68  ARG   N O   1 
ATOM   2708 C CB  . ARG   B 2 106 ? 144.455 133.542 194.940 1.00 137.35 ? 68  ARG   N CB  1 
ATOM   2709 C CG  . ARG   B 2 106 ? 144.974 132.863 196.186 1.00 138.29 ? 68  ARG   N CG  1 
ATOM   2710 C CD  . ARG   B 2 106 ? 145.968 133.767 196.885 1.00 138.35 ? 68  ARG   N CD  1 
ATOM   2711 N NE  . ARG   B 2 106 ? 147.155 133.998 196.071 1.00 139.53 ? 68  ARG   N NE  1 
ATOM   2712 C CZ  . ARG   B 2 106 ? 147.810 135.150 196.018 1.00 139.67 ? 68  ARG   N CZ  1 
ATOM   2713 N NH1 . ARG   B 2 106 ? 147.424 136.197 196.729 1.00 138.56 ? 68  ARG   N NH1 1 
ATOM   2714 N NH2 . ARG   B 2 106 ? 148.876 135.255 195.229 1.00 139.45 ? 68  ARG   N NH2 1 
ATOM   2715 N N   . PHE   B 2 107 ? 142.801 134.048 192.226 1.00 129.76 ? 69  PHE   N N   1 
ATOM   2716 C CA  . PHE   B 2 107 ? 142.219 135.053 191.348 1.00 129.38 ? 69  PHE   N CA  1 
ATOM   2717 C C   . PHE   B 2 107 ? 141.295 134.370 190.349 1.00 127.78 ? 69  PHE   N C   1 
ATOM   2718 O O   . PHE   B 2 107 ? 141.558 133.241 189.928 1.00 127.08 ? 69  PHE   N O   1 
ATOM   2719 C CB  . PHE   B 2 107 ? 143.309 135.844 190.616 1.00 129.30 ? 69  PHE   N CB  1 
ATOM   2720 C CG  . PHE   B 2 107 ? 144.179 136.676 191.526 1.00 130.18 ? 69  PHE   N CG  1 
ATOM   2721 C CD1 . PHE   B 2 107 ? 143.754 137.010 192.801 1.00 130.26 ? 69  PHE   N CD1 1 
ATOM   2722 C CD2 . PHE   B 2 107 ? 145.420 137.128 191.102 1.00 129.16 ? 69  PHE   N CD2 1 
ATOM   2723 C CE1 . PHE   B 2 107 ? 144.550 137.774 193.639 1.00 129.98 ? 69  PHE   N CE1 1 
ATOM   2724 C CE2 . PHE   B 2 107 ? 146.220 137.893 191.937 1.00 129.85 ? 69  PHE   N CE2 1 
ATOM   2725 C CZ  . PHE   B 2 107 ? 145.783 138.215 193.206 1.00 130.21 ? 69  PHE   N CZ  1 
ATOM   2726 N N   . THR   B 2 108 ? 140.193 135.036 190.010 1.00 110.47 ? 70  THR   N N   1 
ATOM   2727 C CA  . THR   B 2 108 ? 139.254 134.561 189.002 1.00 110.15 ? 70  THR   N CA  1 
ATOM   2728 C C   . THR   B 2 108 ? 139.077 135.628 187.931 1.00 110.01 ? 70  THR   N C   1 
ATOM   2729 O O   . THR   B 2 108 ? 138.855 136.801 188.250 1.00 109.73 ? 70  THR   N O   1 
ATOM   2730 C CB  . THR   B 2 108 ? 137.898 134.214 189.620 1.00 109.70 ? 70  THR   N CB  1 
ATOM   2731 O OG1 . THR   B 2 108 ? 138.051 133.116 190.527 1.00 110.30 ? 70  THR   N OG1 1 
ATOM   2732 C CG2 . THR   B 2 108 ? 136.903 133.829 188.535 1.00 110.54 ? 70  THR   N CG2 1 
ATOM   2733 N N   . ILE   B 2 109 ? 139.170 135.219 186.668 1.00 106.77 ? 71  ILE   N N   1 
ATOM   2734 C CA  . ILE   B 2 109 ? 138.990 136.120 185.540 1.00 105.54 ? 71  ILE   N CA  1 
ATOM   2735 C C   . ILE   B 2 109 ? 137.671 135.792 184.850 1.00 105.04 ? 71  ILE   N C   1 
ATOM   2736 O O   . ILE   B 2 109 ? 137.148 134.678 184.936 1.00 107.62 ? 71  ILE   N O   1 
ATOM   2737 C CB  . ILE   B 2 109 ? 140.167 136.048 184.544 1.00 105.07 ? 71  ILE   N CB  1 
ATOM   2738 C CG1 . ILE   B 2 109 ? 140.299 137.367 183.780 1.00 106.69 ? 71  ILE   N CG1 1 
ATOM   2739 C CG2 . ILE   B 2 109 ? 139.990 134.890 183.578 1.00 104.00 ? 71  ILE   N CG2 1 
ATOM   2740 C CD1 . ILE   B 2 109 ? 141.621 137.534 183.074 1.00 106.05 ? 71  ILE   N CD1 1 
ATOM   2741 N N   . SER   B 2 110 ? 137.124 136.793 184.163 1.00 99.50  ? 72  SER   N N   1 
ATOM   2742 C CA  . SER   B 2 110 ? 135.859 136.638 183.462 1.00 100.95 ? 72  SER   N CA  1 
ATOM   2743 C C   . SER   B 2 110 ? 135.863 137.521 182.224 1.00 101.34 ? 72  SER   N C   1 
ATOM   2744 O O   . SER   B 2 110 ? 136.635 138.477 182.122 1.00 101.84 ? 72  SER   N O   1 
ATOM   2745 C CB  . SER   B 2 110 ? 134.668 136.984 184.362 1.00 102.06 ? 72  SER   N CB  1 
ATOM   2746 O OG  . SER   B 2 110 ? 133.616 137.562 183.608 1.00 102.58 ? 72  SER   N OG  1 
ATOM   2747 N N   . ARG   B 2 111 ? 134.986 137.187 181.281 1.00 98.75  ? 73  ARG   N N   1 
ATOM   2748 C CA  . ARG   B 2 111 ? 134.870 137.932 180.035 1.00 96.72  ? 73  ARG   N CA  1 
ATOM   2749 C C   . ARG   B 2 111 ? 133.458 137.784 179.490 1.00 96.92  ? 73  ARG   N C   1 
ATOM   2750 O O   . ARG   B 2 111 ? 132.961 136.663 179.350 1.00 99.16  ? 73  ARG   N O   1 
ATOM   2751 C CB  . ARG   B 2 111 ? 135.887 137.439 178.999 1.00 94.93  ? 73  ARG   N CB  1 
ATOM   2752 C CG  . ARG   B 2 111 ? 135.670 138.009 177.607 1.00 97.16  ? 73  ARG   N CG  1 
ATOM   2753 C CD  . ARG   B 2 111 ? 136.760 137.570 176.647 1.00 97.17  ? 73  ARG   N CD  1 
ATOM   2754 N NE  . ARG   B 2 111 ? 136.401 137.852 175.263 1.00 97.27  ? 73  ARG   N NE  1 
ATOM   2755 C CZ  . ARG   B 2 111 ? 137.263 137.873 174.255 1.00 96.04  ? 73  ARG   N CZ  1 
ATOM   2756 N NH1 . ARG   B 2 111 ? 138.549 137.622 174.440 1.00 96.58  ? 73  ARG   N NH1 1 
ATOM   2757 N NH2 . ARG   B 2 111 ? 136.823 138.156 173.033 1.00 94.69  ? 73  ARG   N NH2 1 
ATOM   2758 N N   . ASP   B 2 112 ? 132.822 138.910 179.179 1.00 100.92 ? 74  ASP   N N   1 
ATOM   2759 C CA  . ASP   B 2 112 ? 131.498 138.933 178.561 1.00 101.83 ? 74  ASP   N CA  1 
ATOM   2760 C C   . ASP   B 2 112 ? 131.651 139.563 177.181 1.00 101.14 ? 74  ASP   N C   1 
ATOM   2761 O O   . ASP   B 2 112 ? 131.784 140.785 177.060 1.00 103.44 ? 74  ASP   N O   1 
ATOM   2762 C CB  . ASP   B 2 112 ? 130.495 139.695 179.422 1.00 103.93 ? 74  ASP   N CB  1 
ATOM   2763 C CG  . ASP   B 2 112 ? 129.072 139.581 178.904 1.00 104.00 ? 74  ASP   N CG  1 
ATOM   2764 O OD1 . ASP   B 2 112 ? 128.833 138.774 177.980 1.00 104.01 ? 74  ASP   N OD1 1 
ATOM   2765 O OD2 . ASP   B 2 112 ? 128.188 140.293 179.424 1.00 104.61 ? 74  ASP   N OD2 1 
ATOM   2766 N N   . ASN   B 2 113 ? 131.630 138.723 176.144 1.00 98.74  ? 75  ASN   N N   1 
ATOM   2767 C CA  . ASN   B 2 113 ? 131.854 139.209 174.787 1.00 100.97 ? 75  ASN   N CA  1 
ATOM   2768 C C   . ASN   B 2 113 ? 130.770 140.185 174.352 1.00 101.91 ? 75  ASN   N C   1 
ATOM   2769 O O   . ASN   B 2 113 ? 131.064 141.174 173.672 1.00 100.76 ? 75  ASN   N O   1 
ATOM   2770 C CB  . ASN   B 2 113 ? 131.929 138.029 173.819 1.00 102.81 ? 75  ASN   N CB  1 
ATOM   2771 C CG  . ASN   B 2 113 ? 133.094 137.108 174.117 1.00 101.86 ? 75  ASN   N CG  1 
ATOM   2772 O OD1 . ASN   B 2 113 ? 134.254 137.474 173.932 1.00 100.07 ? 75  ASN   N OD1 1 
ATOM   2773 N ND2 . ASN   B 2 113 ? 132.789 135.905 174.588 1.00 101.21 ? 75  ASN   N ND2 1 
ATOM   2774 N N   . ALA   B 2 114 ? 129.515 139.923 174.726 1.00 109.79 ? 76  ALA   N N   1 
ATOM   2775 C CA  . ALA   B 2 114 ? 128.438 140.848 174.392 1.00 109.78 ? 76  ALA   N CA  1 
ATOM   2776 C C   . ALA   B 2 114 ? 128.638 142.193 175.078 1.00 109.28 ? 76  ALA   N C   1 
ATOM   2777 O O   . ALA   B 2 114 ? 128.366 143.246 174.489 1.00 109.73 ? 76  ALA   N O   1 
ATOM   2778 C CB  . ALA   B 2 114 ? 127.087 140.243 174.772 1.00 109.64 ? 76  ALA   N CB  1 
ATOM   2779 N N   . LYS   B 2 115 ? 129.110 142.179 176.322 1.00 106.41 ? 77  LYS   N N   1 
ATOM   2780 C CA  . LYS   B 2 115 ? 129.381 143.403 177.065 1.00 107.39 ? 77  LYS   N CA  1 
ATOM   2781 C C   . LYS   B 2 115 ? 130.766 143.966 176.791 1.00 108.74 ? 77  LYS   N C   1 
ATOM   2782 O O   . LYS   B 2 115 ? 131.060 145.082 177.233 1.00 109.47 ? 77  LYS   N O   1 
ATOM   2783 C CB  . LYS   B 2 115 ? 129.217 143.159 178.568 1.00 105.48 ? 77  LYS   N CB  1 
ATOM   2784 N N   . ASN   B 2 116 ? 131.617 143.221 176.084 1.00 103.22 ? 78  ASN   N N   1 
ATOM   2785 C CA  . ASN   B 2 116 ? 132.946 143.691 175.690 1.00 102.52 ? 78  ASN   N CA  1 
ATOM   2786 C C   . ASN   B 2 116 ? 133.761 144.129 176.905 1.00 101.03 ? 78  ASN   N C   1 
ATOM   2787 O O   . ASN   B 2 116 ? 134.217 145.269 176.994 1.00 100.82 ? 78  ASN   N O   1 
ATOM   2788 C CB  . ASN   B 2 116 ? 132.835 144.829 174.675 1.00 102.05 ? 78  ASN   N CB  1 
ATOM   2789 C CG  . ASN   B 2 116 ? 134.071 144.968 173.817 1.00 100.95 ? 78  ASN   N CG  1 
ATOM   2790 O OD1 . ASN   B 2 116 ? 135.052 145.591 174.218 1.00 101.08 ? 78  ASN   N OD1 1 
ATOM   2791 N ND2 . ASN   B 2 116 ? 134.018 144.412 172.614 1.00 99.44  ? 78  ASN   N ND2 1 
ATOM   2792 N N   . THR   B 2 117 ? 133.948 143.211 177.852 1.00 98.17  ? 79  THR   N N   1 
ATOM   2793 C CA  . THR   B 2 117 ? 134.626 143.515 179.104 1.00 99.02  ? 79  THR   N CA  1 
ATOM   2794 C C   . THR   B 2 117 ? 135.369 142.291 179.619 1.00 99.20  ? 79  THR   N C   1 
ATOM   2795 O O   . THR   B 2 117 ? 135.027 141.151 179.295 1.00 100.10 ? 79  THR   N O   1 
ATOM   2796 C CB  . THR   B 2 117 ? 133.639 143.991 180.181 1.00 100.96 ? 79  THR   N CB  1 
ATOM   2797 O OG1 . THR   B 2 117 ? 132.407 143.271 180.054 1.00 99.37  ? 79  THR   N OG1 1 
ATOM   2798 C CG2 . THR   B 2 117 ? 133.373 145.484 180.061 1.00 99.83  ? 79  THR   N CG2 1 
ATOM   2799 N N   . VAL   B 2 118 ? 136.391 142.546 180.432 1.00 99.63  ? 80  VAL   N N   1 
ATOM   2800 C CA  . VAL   B 2 118 ? 137.129 141.511 181.144 1.00 100.22 ? 80  VAL   N CA  1 
ATOM   2801 C C   . VAL   B 2 118 ? 137.207 141.904 182.614 1.00 100.60 ? 80  VAL   N C   1 
ATOM   2802 O O   . VAL   B 2 118 ? 137.701 142.987 182.951 1.00 100.57 ? 80  VAL   N O   1 
ATOM   2803 C CB  . VAL   B 2 118 ? 138.531 141.288 180.544 1.00 99.09  ? 80  VAL   N CB  1 
ATOM   2804 C CG1 . VAL   B 2 118 ? 139.233 142.609 180.306 1.00 97.51  ? 80  VAL   N CG1 1 
ATOM   2805 C CG2 . VAL   B 2 118 ? 139.364 140.407 181.460 1.00 99.43  ? 80  VAL   N CG2 1 
ATOM   2806 N N   . TYR   B 2 119 ? 136.708 141.029 183.483 1.00 106.97 ? 81  TYR   N N   1 
ATOM   2807 C CA  . TYR   B 2 119 ? 136.635 141.282 184.915 1.00 105.63 ? 81  TYR   N CA  1 
ATOM   2808 C C   . TYR   B 2 119 ? 137.583 140.343 185.644 1.00 106.20 ? 81  TYR   N C   1 
ATOM   2809 O O   . TYR   B 2 119 ? 137.534 139.126 185.440 1.00 109.04 ? 81  TYR   N O   1 
ATOM   2810 C CB  . TYR   B 2 119 ? 135.210 141.082 185.436 1.00 106.56 ? 81  TYR   N CB  1 
ATOM   2811 C CG  . TYR   B 2 119 ? 134.161 141.917 184.740 1.00 107.78 ? 81  TYR   N CG  1 
ATOM   2812 C CD1 . TYR   B 2 119 ? 134.066 143.283 184.970 1.00 107.82 ? 81  TYR   N CD1 1 
ATOM   2813 C CD2 . TYR   B 2 119 ? 133.259 141.336 183.859 1.00 107.43 ? 81  TYR   N CD2 1 
ATOM   2814 C CE1 . TYR   B 2 119 ? 133.103 144.047 184.338 1.00 106.60 ? 81  TYR   N CE1 1 
ATOM   2815 C CE2 . TYR   B 2 119 ? 132.295 142.092 183.223 1.00 106.98 ? 81  TYR   N CE2 1 
ATOM   2816 C CZ  . TYR   B 2 119 ? 132.221 143.446 183.466 1.00 106.59 ? 81  TYR   N CZ  1 
ATOM   2817 O OH  . TYR   B 2 119 ? 131.262 144.202 182.834 1.00 106.19 ? 81  TYR   N OH  1 
ATOM   2818 N N   . LEU   B 2 120 ? 138.435 140.907 186.494 1.00 109.06 ? 82  LEU   N N   1 
ATOM   2819 C CA  . LEU   B 2 120 ? 139.351 140.135 187.320 1.00 112.37 ? 82  LEU   N CA  1 
ATOM   2820 C C   . LEU   B 2 120 ? 138.961 140.305 188.780 1.00 114.20 ? 82  LEU   N C   1 
ATOM   2821 O O   . LEU   B 2 120 ? 138.952 141.427 189.297 1.00 114.90 ? 82  LEU   N O   1 
ATOM   2822 C CB  . LEU   B 2 120 ? 140.800 140.577 187.099 1.00 110.89 ? 82  LEU   N CB  1 
ATOM   2823 C CG  . LEU   B 2 120 ? 141.882 139.674 187.693 1.00 111.68 ? 82  LEU   N CG  1 
ATOM   2824 C CD1 . LEU   B 2 120 ? 142.007 138.398 186.883 1.00 112.74 ? 82  LEU   N CD1 1 
ATOM   2825 C CD2 . LEU   B 2 120 ? 143.217 140.399 187.765 1.00 110.83 ? 82  LEU   N CD2 1 
ATOM   2826 N N   . GLN   B 2 121 ? 138.646 139.196 189.441 1.00 121.32 ? 83  GLN   N N   1 
ATOM   2827 C CA  . GLN   B 2 121 ? 138.254 139.207 190.843 1.00 120.21 ? 83  GLN   N CA  1 
ATOM   2828 C C   . GLN   B 2 121 ? 139.468 138.910 191.709 1.00 119.58 ? 83  GLN   N C   1 
ATOM   2829 O O   . GLN   B 2 121 ? 140.181 137.929 191.475 1.00 118.74 ? 83  GLN   N O   1 
ATOM   2830 C CB  . GLN   B 2 121 ? 137.143 138.191 191.116 1.00 120.46 ? 83  GLN   N CB  1 
ATOM   2831 C CG  . GLN   B 2 121 ? 135.745 138.712 190.825 1.00 121.31 ? 83  GLN   N CG  1 
ATOM   2832 C CD  . GLN   B 2 121 ? 134.702 137.611 190.794 1.00 120.79 ? 83  GLN   N CD  1 
ATOM   2833 O OE1 . GLN   B 2 121 ? 133.961 137.415 191.756 1.00 119.63 ? 83  GLN   N OE1 1 
ATOM   2834 N NE2 . GLN   B 2 121 ? 134.637 136.889 189.682 1.00 120.77 ? 83  GLN   N NE2 1 
ATOM   2835 N N   . MET   B 2 122 ? 139.696 139.758 192.706 1.00 135.40 ? 84  MET   N N   1 
ATOM   2836 C CA  . MET   B 2 122 ? 140.863 139.667 193.571 1.00 136.44 ? 84  MET   N CA  1 
ATOM   2837 C C   . MET   B 2 122 ? 140.430 139.190 194.952 1.00 137.90 ? 84  MET   N C   1 
ATOM   2838 O O   . MET   B 2 122 ? 139.554 139.797 195.578 1.00 138.14 ? 84  MET   N O   1 
ATOM   2839 C CB  . MET   B 2 122 ? 141.569 141.019 193.656 1.00 136.25 ? 84  MET   N CB  1 
ATOM   2840 C CG  . MET   B 2 122 ? 142.704 141.074 194.659 1.00 137.28 ? 84  MET   N CG  1 
ATOM   2841 S SD  . MET   B 2 122 ? 142.770 142.669 195.495 1.00 139.65 ? 84  MET   N SD  1 
ATOM   2842 C CE  . MET   B 2 122 ? 141.039 142.923 195.871 1.00 137.26 ? 84  MET   N CE  1 
ATOM   2843 N N   . SER   B 2 123 ? 141.046 138.108 195.421 1.00 141.51 ? 85  SER   N N   1 
ATOM   2844 C CA  . SER   B 2 123 ? 140.747 137.533 196.723 1.00 141.50 ? 85  SER   N CA  1 
ATOM   2845 C C   . SER   B 2 123 ? 142.025 136.987 197.342 1.00 141.60 ? 85  SER   N C   1 
ATOM   2846 O O   . SER   B 2 123 ? 142.974 136.640 196.634 1.00 141.11 ? 85  SER   N O   1 
ATOM   2847 C CB  . SER   B 2 123 ? 139.699 136.419 196.614 1.00 140.50 ? 85  SER   N CB  1 
ATOM   2848 O OG  . SER   B 2 123 ? 140.198 135.327 195.860 1.00 139.40 ? 85  SER   N OG  1 
ATOM   2849 N N   . SER   B 2 124 ? 142.034 136.912 198.672 1.00 147.14 ? 86  SER   N N   1 
ATOM   2850 C CA  . SER   B 2 124 ? 143.185 136.434 199.437 1.00 147.53 ? 86  SER   N CA  1 
ATOM   2851 C C   . SER   B 2 124 ? 144.431 137.261 199.114 1.00 148.27 ? 86  SER   N C   1 
ATOM   2852 O O   . SER   B 2 124 ? 145.401 136.782 198.524 1.00 148.64 ? 86  SER   N O   1 
ATOM   2853 C CB  . SER   B 2 124 ? 143.427 134.942 199.193 1.00 147.85 ? 86  SER   N CB  1 
ATOM   2854 O OG  . SER   B 2 124 ? 144.620 134.507 199.821 1.00 147.68 ? 86  SER   N OG  1 
ATOM   2855 N N   . LEU   B 2 125 ? 144.375 138.531 199.512 1.00 149.11 ? 87  LEU   N N   1 
ATOM   2856 C CA  . LEU   B 2 125 ? 145.448 139.468 199.210 1.00 149.49 ? 87  LEU   N CA  1 
ATOM   2857 C C   . LEU   B 2 125 ? 146.768 139.030 199.831 1.00 150.02 ? 87  LEU   N C   1 
ATOM   2858 O O   . LEU   B 2 125 ? 146.806 138.462 200.926 1.00 150.09 ? 87  LEU   N O   1 
ATOM   2859 C CB  . LEU   B 2 125 ? 145.084 140.866 199.708 1.00 149.14 ? 87  LEU   N CB  1 
ATOM   2860 C CG  . LEU   B 2 125 ? 144.333 141.760 198.725 1.00 148.81 ? 87  LEU   N CG  1 
ATOM   2861 C CD1 . LEU   B 2 125 ? 143.409 142.716 199.460 1.00 149.41 ? 87  LEU   N CD1 1 
ATOM   2862 C CD2 . LEU   B 2 125 ? 145.335 142.524 197.879 1.00 147.85 ? 87  LEU   N CD2 1 
ATOM   2863 N N   . LYS   B 2 126 ? 147.853 139.300 199.115 1.00 154.27 ? 88  LYS   N N   1 
ATOM   2864 C CA  . LYS   B 2 126 ? 149.217 139.059 199.549 1.00 154.23 ? 88  LYS   N CA  1 
ATOM   2865 C C   . LYS   B 2 126 ? 150.032 140.327 199.347 1.00 155.36 ? 88  LYS   N C   1 
ATOM   2866 O O   . LYS   B 2 126 ? 149.673 141.172 198.521 1.00 154.98 ? 88  LYS   N O   1 
ATOM   2867 C CB  . LYS   B 2 126 ? 149.853 137.899 198.768 1.00 153.01 ? 88  LYS   N CB  1 
ATOM   2868 N N   . PRO   B 2 127 ? 151.123 140.497 200.100 1.00 157.94 ? 89  PRO   N N   1 
ATOM   2869 C CA  . PRO   B 2 127 ? 151.931 141.719 199.942 1.00 156.88 ? 89  PRO   N CA  1 
ATOM   2870 C C   . PRO   B 2 127 ? 152.475 141.918 198.538 1.00 156.69 ? 89  PRO   N C   1 
ATOM   2871 O O   . PRO   B 2 127 ? 152.609 143.065 198.094 1.00 155.65 ? 89  PRO   N O   1 
ATOM   2872 C CB  . PRO   B 2 127 ? 153.062 141.524 200.961 1.00 156.77 ? 89  PRO   N CB  1 
ATOM   2873 C CG  . PRO   B 2 127 ? 152.510 140.570 201.965 1.00 157.09 ? 89  PRO   N CG  1 
ATOM   2874 C CD  . PRO   B 2 127 ? 151.615 139.647 201.198 1.00 156.97 ? 89  PRO   N CD  1 
ATOM   2875 N N   . GLU   B 2 128 ? 152.790 140.837 197.821 1.00 158.16 ? 90  GLU   N N   1 
ATOM   2876 C CA  . GLU   B 2 128 ? 153.360 140.962 196.484 1.00 157.71 ? 90  GLU   N CA  1 
ATOM   2877 C C   . GLU   B 2 128 ? 152.332 141.353 195.430 1.00 156.95 ? 90  GLU   N C   1 
ATOM   2878 O O   . GLU   B 2 128 ? 152.723 141.677 194.304 1.00 156.82 ? 90  GLU   N O   1 
ATOM   2879 C CB  . GLU   B 2 128 ? 154.037 139.651 196.076 1.00 157.52 ? 90  GLU   N CB  1 
ATOM   2880 C CG  . GLU   B 2 128 ? 155.155 139.209 197.008 1.00 157.38 ? 90  GLU   N CG  1 
ATOM   2881 C CD  . GLU   B 2 128 ? 154.670 138.277 198.101 1.00 157.23 ? 90  GLU   N CD  1 
ATOM   2882 O OE1 . GLU   B 2 128 ? 153.489 137.873 198.060 1.00 157.05 ? 90  GLU   N OE1 1 
ATOM   2883 O OE2 . GLU   B 2 128 ? 155.470 137.948 199.002 1.00 157.00 ? 90  GLU   N OE2 1 
ATOM   2884 N N   . ASP   B 2 129 ? 151.041 141.335 195.760 1.00 153.26 ? 91  ASP   N N   1 
ATOM   2885 C CA  . ASP   B 2 129 ? 150.003 141.636 194.782 1.00 153.11 ? 91  ASP   N CA  1 
ATOM   2886 C C   . ASP   B 2 129 ? 149.827 143.127 194.527 1.00 153.45 ? 91  ASP   N C   1 
ATOM   2887 O O   . ASP   B 2 129 ? 149.108 143.494 193.592 1.00 153.31 ? 91  ASP   N O   1 
ATOM   2888 C CB  . ASP   B 2 129 ? 148.670 141.035 195.231 1.00 153.21 ? 91  ASP   N CB  1 
ATOM   2889 C CG  . ASP   B 2 129 ? 148.770 139.552 195.526 1.00 153.40 ? 91  ASP   N CG  1 
ATOM   2890 O OD1 . ASP   B 2 129 ? 149.600 138.873 194.886 1.00 152.78 ? 91  ASP   N OD1 1 
ATOM   2891 O OD2 . ASP   B 2 129 ? 148.019 139.066 196.397 1.00 153.35 ? 91  ASP   N OD2 1 
ATOM   2892 N N   . THR   B 2 130 ? 150.457 143.990 195.320 1.00 152.49 ? 92  THR   N N   1 
ATOM   2893 C CA  . THR   B 2 130 ? 150.334 145.434 195.132 1.00 152.54 ? 92  THR   N CA  1 
ATOM   2894 C C   . THR   B 2 130 ? 151.251 145.861 193.993 1.00 152.39 ? 92  THR   N C   1 
ATOM   2895 O O   . THR   B 2 130 ? 152.472 145.928 194.152 1.00 152.04 ? 92  THR   N O   1 
ATOM   2896 C CB  . THR   B 2 130 ? 150.678 146.173 196.421 1.00 151.81 ? 92  THR   N CB  1 
ATOM   2897 O OG1 . THR   B 2 130 ? 149.729 145.828 197.437 1.00 151.97 ? 92  THR   N OG1 1 
ATOM   2898 C CG2 . THR   B 2 130 ? 150.642 147.678 196.198 1.00 150.77 ? 92  THR   N CG2 1 
ATOM   2899 N N   . ALA   B 2 131 ? 150.665 146.152 192.840 1.00 140.60 ? 93  ALA   N N   1 
ATOM   2900 C CA  . ALA   B 2 131 ? 151.416 146.537 191.648 1.00 139.36 ? 93  ALA   N CA  1 
ATOM   2901 C C   . ALA   B 2 131 ? 150.454 147.241 190.696 1.00 138.43 ? 93  ALA   N C   1 
ATOM   2902 O O   . ALA   B 2 131 ? 149.299 147.516 191.045 1.00 137.84 ? 93  ALA   N O   1 
ATOM   2903 C CB  . ALA   B 2 131 ? 152.084 145.323 190.999 1.00 138.42 ? 93  ALA   N CB  1 
ATOM   2904 N N   . VAL   B 2 132 ? 150.930 147.529 189.488 1.00 129.84 ? 94  VAL   N N   1 
ATOM   2905 C CA  . VAL   B 2 132 ? 150.149 148.215 188.465 1.00 129.72 ? 94  VAL   N CA  1 
ATOM   2906 C C   . VAL   B 2 132 ? 149.642 147.181 187.472 1.00 129.08 ? 94  VAL   N C   1 
ATOM   2907 O O   . VAL   B 2 132 ? 150.415 146.349 186.981 1.00 127.32 ? 94  VAL   N O   1 
ATOM   2908 C CB  . VAL   B 2 132 ? 150.983 149.296 187.757 1.00 128.98 ? 94  VAL   N CB  1 
ATOM   2909 C CG1 . VAL   B 2 132 ? 150.120 150.082 186.782 1.00 127.95 ? 94  VAL   N CG1 1 
ATOM   2910 C CG2 . VAL   B 2 132 ? 151.633 150.220 188.777 1.00 128.11 ? 94  VAL   N CG2 1 
ATOM   2911 N N   . TYR   B 2 133 ? 148.347 147.230 187.175 1.00 121.44 ? 95  TYR   N N   1 
ATOM   2912 C CA  . TYR   B 2 133 ? 147.702 146.271 186.289 1.00 120.76 ? 95  TYR   N CA  1 
ATOM   2913 C C   . TYR   B 2 133 ? 147.433 146.918 184.937 1.00 118.54 ? 95  TYR   N C   1 
ATOM   2914 O O   . TYR   B 2 133 ? 146.820 147.989 184.867 1.00 117.08 ? 95  TYR   N O   1 
ATOM   2915 C CB  . TYR   B 2 133 ? 146.396 145.757 186.900 1.00 121.77 ? 95  TYR   N CB  1 
ATOM   2916 C CG  . TYR   B 2 133 ? 146.587 144.780 188.038 1.00 122.23 ? 95  TYR   N CG  1 
ATOM   2917 C CD1 . TYR   B 2 133 ? 146.978 145.217 189.297 1.00 121.33 ? 95  TYR   N CD1 1 
ATOM   2918 C CD2 . TYR   B 2 133 ? 146.372 143.420 187.855 1.00 120.72 ? 95  TYR   N CD2 1 
ATOM   2919 C CE1 . TYR   B 2 133 ? 147.153 144.328 190.341 1.00 121.04 ? 95  TYR   N CE1 1 
ATOM   2920 C CE2 . TYR   B 2 133 ? 146.544 142.523 188.893 1.00 120.54 ? 95  TYR   N CE2 1 
ATOM   2921 C CZ  . TYR   B 2 133 ? 146.934 142.983 190.134 1.00 121.50 ? 95  TYR   N CZ  1 
ATOM   2922 O OH  . TYR   B 2 133 ? 147.107 142.095 191.171 1.00 121.56 ? 95  TYR   N OH  1 
ATOM   2923 N N   . TYR   B 2 134 ? 147.885 146.264 183.871 1.00 106.48 ? 96  TYR   N N   1 
ATOM   2924 C CA  . TYR   B 2 134 ? 147.685 146.728 182.504 1.00 106.08 ? 96  TYR   N CA  1 
ATOM   2925 C C   . TYR   B 2 134 ? 146.750 145.765 181.786 1.00 105.64 ? 96  TYR   N C   1 
ATOM   2926 O O   . TYR   B 2 134 ? 147.009 144.558 181.747 1.00 106.75 ? 96  TYR   N O   1 
ATOM   2927 C CB  . TYR   B 2 134 ? 149.012 146.827 181.754 1.00 105.72 ? 96  TYR   N CB  1 
ATOM   2928 C CG  . TYR   B 2 134 ? 149.978 147.854 182.301 1.00 107.95 ? 96  TYR   N CG  1 
ATOM   2929 C CD1 . TYR   B 2 134 ? 150.781 147.569 183.396 1.00 108.11 ? 96  TYR   N CD1 1 
ATOM   2930 C CD2 . TYR   B 2 134 ? 150.096 149.104 181.710 1.00 108.48 ? 96  TYR   N CD2 1 
ATOM   2931 C CE1 . TYR   B 2 134 ? 151.667 148.505 183.892 1.00 108.21 ? 96  TYR   N CE1 1 
ATOM   2932 C CE2 . TYR   B 2 134 ? 150.979 150.045 182.199 1.00 108.48 ? 96  TYR   N CE2 1 
ATOM   2933 C CZ  . TYR   B 2 134 ? 151.762 149.741 183.290 1.00 108.33 ? 96  TYR   N CZ  1 
ATOM   2934 O OH  . TYR   B 2 134 ? 152.642 150.677 183.780 1.00 108.27 ? 96  TYR   N OH  1 
ATOM   2935 N N   . CYS   B 2 135 ? 145.675 146.298 181.213 1.00 92.49  ? 97  CYS   N N   1 
ATOM   2936 C CA  . CYS   B 2 135 ? 144.739 145.487 180.448 1.00 88.58  ? 97  CYS   N CA  1 
ATOM   2937 C C   . CYS   B 2 135 ? 145.224 145.346 179.012 1.00 88.28  ? 97  CYS   N C   1 
ATOM   2938 O O   . CYS   B 2 135 ? 145.554 146.339 178.358 1.00 93.30  ? 97  CYS   N O   1 
ATOM   2939 C CB  . CYS   B 2 135 ? 143.345 146.111 180.478 1.00 90.70  ? 97  CYS   N CB  1 
ATOM   2940 S SG  . CYS   B 2 135 ? 142.118 145.261 179.471 1.00 94.61  ? 97  CYS   N SG  1 
ATOM   2941 N N   . ASN   B 2 136 ? 145.266 144.110 178.524 1.00 77.23  ? 98  ASN   N N   1 
ATOM   2942 C CA  . ASN   B 2 136 ? 145.702 143.810 177.170 1.00 75.06  ? 98  ASN   N CA  1 
ATOM   2943 C C   . ASN   B 2 136 ? 144.575 143.126 176.408 1.00 76.84  ? 98  ASN   N C   1 
ATOM   2944 O O   . ASN   B 2 136 ? 143.783 142.375 176.982 1.00 81.29  ? 98  ASN   N O   1 
ATOM   2945 C CB  . ASN   B 2 136 ? 146.951 142.921 177.178 1.00 77.36  ? 98  ASN   N CB  1 
ATOM   2946 C CG  . ASN   B 2 136 ? 147.630 142.850 175.825 1.00 78.62  ? 98  ASN   N CG  1 
ATOM   2947 O OD1 . ASN   B 2 136 ? 147.000 143.047 174.788 1.00 78.30  ? 98  ASN   N OD1 1 
ATOM   2948 N ND2 . ASN   B 2 136 ? 148.926 142.566 175.832 1.00 80.04  ? 98  ASN   N ND2 1 
ATOM   2949 N N   . ALA   B 2 137 ? 144.510 143.394 175.107 1.00 66.77  ? 99  ALA   N N   1 
ATOM   2950 C CA  . ALA   B 2 137 ? 143.487 142.801 174.259 1.00 66.33  ? 99  ALA   N CA  1 
ATOM   2951 C C   . ALA   B 2 137 ? 144.002 142.720 172.832 1.00 65.36  ? 99  ALA   N C   1 
ATOM   2952 O O   . ALA   B 2 137 ? 144.741 143.599 172.381 1.00 70.98  ? 99  ALA   N O   1 
ATOM   2953 C CB  . ALA   B 2 137 ? 142.185 143.606 174.306 1.00 67.38  ? 99  ALA   N CB  1 
ATOM   2954 N N   . GLU   B 2 138 ? 143.609 141.663 172.129 1.00 62.62  ? 100 GLU   N N   1 
ATOM   2955 C CA  . GLU   B 2 138 ? 143.976 141.451 170.735 1.00 64.70  ? 100 GLU   N CA  1 
ATOM   2956 C C   . GLU   B 2 138 ? 142.722 141.577 169.883 1.00 67.90  ? 100 GLU   N C   1 
ATOM   2957 O O   . GLU   B 2 138 ? 141.749 140.847 170.097 1.00 68.29  ? 100 GLU   N O   1 
ATOM   2958 C CB  . GLU   B 2 138 ? 144.625 140.081 170.545 1.00 68.65  ? 100 GLU   N CB  1 
ATOM   2959 C CG  . GLU   B 2 138 ? 146.109 140.049 170.863 1.00 71.95  ? 100 GLU   N CG  1 
ATOM   2960 C CD  . GLU   B 2 138 ? 146.671 138.641 170.886 1.00 73.93  ? 100 GLU   N CD  1 
ATOM   2961 O OE1 . GLU   B 2 138 ? 147.562 138.368 171.717 1.00 71.96  ? 100 GLU   N OE1 1 
ATOM   2962 O OE2 . GLU   B 2 138 ? 146.221 137.808 170.073 1.00 74.03  ? 100 GLU   N OE2 1 
ATOM   2963 N N   . TYR   B 2 139 ? 142.748 142.490 168.916 1.00 67.29  ? 101 TYR   N N   1 
ATOM   2964 C CA  . TYR   B 2 139 ? 141.573 142.805 168.118 1.00 64.97  ? 101 TYR   N CA  1 
ATOM   2965 C C   . TYR   B 2 139 ? 141.929 142.797 166.639 1.00 65.24  ? 101 TYR   N C   1 
ATOM   2966 O O   . TYR   B 2 139 ? 143.099 142.833 166.252 1.00 69.06  ? 101 TYR   N O   1 
ATOM   2967 C CB  . TYR   B 2 139 ? 140.975 144.164 168.514 1.00 67.63  ? 101 TYR   N CB  1 
ATOM   2968 C CG  . TYR   B 2 139 ? 141.883 145.348 168.265 1.00 68.98  ? 101 TYR   N CG  1 
ATOM   2969 C CD1 . TYR   B 2 139 ? 141.844 146.039 167.062 1.00 70.44  ? 101 TYR   N CD1 1 
ATOM   2970 C CD2 . TYR   B 2 139 ? 142.781 145.772 169.233 1.00 68.28  ? 101 TYR   N CD2 1 
ATOM   2971 C CE1 . TYR   B 2 139 ? 142.671 147.119 166.832 1.00 70.06  ? 101 TYR   N CE1 1 
ATOM   2972 C CE2 . TYR   B 2 139 ? 143.612 146.850 169.012 1.00 69.19  ? 101 TYR   N CE2 1 
ATOM   2973 C CZ  . TYR   B 2 139 ? 143.554 147.520 167.810 1.00 72.15  ? 101 TYR   N CZ  1 
ATOM   2974 O OH  . TYR   B 2 139 ? 144.382 148.595 167.586 1.00 73.07  ? 101 TYR   N OH  1 
ATOM   2975 N N   . ARG   B 2 140 ? 140.889 142.743 165.811 1.00 56.80  ? 102 ARG   N N   1 
ATOM   2976 C CA  . ARG   B 2 140 ? 141.030 142.819 164.364 1.00 58.87  ? 102 ARG   N CA  1 
ATOM   2977 C C   . ARG   B 2 140 ? 139.973 143.773 163.831 1.00 60.85  ? 102 ARG   N C   1 
ATOM   2978 O O   . ARG   B 2 140 ? 138.787 143.616 164.132 1.00 61.37  ? 102 ARG   N O   1 
ATOM   2979 C CB  . ARG   B 2 140 ? 140.884 141.437 163.721 1.00 59.26  ? 102 ARG   N CB  1 
ATOM   2980 C CG  . ARG   B 2 140 ? 141.406 141.355 162.303 1.00 58.77  ? 102 ARG   N CG  1 
ATOM   2981 C CD  . ARG   B 2 140 ? 141.492 139.920 161.828 1.00 53.23  ? 102 ARG   N CD  1 
ATOM   2982 N NE  . ARG   B 2 140 ? 142.836 139.379 161.979 1.00 55.05  ? 102 ARG   N NE  1 
ATOM   2983 C CZ  . ARG   B 2 140 ? 143.104 138.138 162.360 1.00 57.97  ? 102 ARG   N CZ  1 
ATOM   2984 N NH1 . ARG   B 2 140 ? 142.139 137.279 162.640 1.00 58.56  ? 102 ARG   N NH1 1 
ATOM   2985 N NH2 . ARG   B 2 140 ? 144.371 137.750 162.461 1.00 59.84  ? 102 ARG   N NH2 1 
ATOM   2986 N N   . THR   B 2 141 ? 140.403 144.760 163.045 1.00 59.23  ? 103 THR   N N   1 
ATOM   2987 C CA  . THR   B 2 141 ? 139.500 145.797 162.562 1.00 55.90  ? 103 THR   N CA  1 
ATOM   2988 C C   . THR   B 2 141 ? 138.720 145.389 161.319 1.00 58.70  ? 103 THR   N C   1 
ATOM   2989 O O   . THR   B 2 141 ? 137.763 146.081 160.959 1.00 62.50  ? 103 THR   N O   1 
ATOM   2990 C CB  . THR   B 2 141 ? 140.282 147.078 162.268 1.00 58.51  ? 103 THR   N CB  1 
ATOM   2991 O OG1 . THR   B 2 141 ? 141.450 146.760 161.503 1.00 59.75  ? 103 THR   N OG1 1 
ATOM   2992 C CG2 . THR   B 2 141 ? 140.703 147.750 163.564 1.00 60.25  ? 103 THR   N CG2 1 
ATOM   2993 N N   . GLY   B 2 142 ? 139.098 144.300 160.661 1.00 53.94  ? 104 GLY   N N   1 
ATOM   2994 C CA  . GLY   B 2 142 ? 138.388 143.853 159.476 1.00 47.31  ? 104 GLY   N CA  1 
ATOM   2995 C C   . GLY   B 2 142 ? 138.814 142.450 159.116 1.00 50.69  ? 104 GLY   N C   1 
ATOM   2996 O O   . GLY   B 2 142 ? 139.811 141.931 159.623 1.00 54.76  ? 104 GLY   N O   1 
ATOM   2997 N N   . ILE   B 2 143 ? 138.038 141.838 158.218 1.00 51.55  ? 105 ILE   N N   1 
ATOM   2998 C CA  . ILE   B 2 143 ? 138.320 140.462 157.816 1.00 50.65  ? 105 ILE   N CA  1 
ATOM   2999 C C   . ILE   B 2 143 ? 139.688 140.369 157.153 1.00 50.67  ? 105 ILE   N C   1 
ATOM   3000 O O   . ILE   B 2 143 ? 140.470 139.454 157.434 1.00 53.25  ? 105 ILE   N O   1 
ATOM   3001 C CB  . ILE   B 2 143 ? 137.210 139.932 156.890 1.00 47.31  ? 105 ILE   N CB  1 
ATOM   3002 C CG1 . ILE   B 2 143 ? 135.883 139.840 157.637 1.00 51.42  ? 105 ILE   N CG1 1 
ATOM   3003 C CG2 . ILE   B 2 143 ? 137.582 138.572 156.342 1.00 50.71  ? 105 ILE   N CG2 1 
ATOM   3004 C CD1 . ILE   B 2 143 ? 134.800 139.134 156.855 1.00 49.60  ? 105 ILE   N CD1 1 
ATOM   3005 N N   . TRP   B 2 144 ? 140.001 141.314 156.274 1.00 46.91  ? 106 TRP   N N   1 
ATOM   3006 C CA  . TRP   B 2 144 ? 141.238 141.295 155.507 1.00 48.07  ? 106 TRP   N CA  1 
ATOM   3007 C C   . TRP   B 2 144 ? 142.397 141.963 156.229 1.00 47.27  ? 106 TRP   N C   1 
ATOM   3008 O O   . TRP   B 2 144 ? 143.498 142.028 155.673 1.00 52.23  ? 106 TRP   N O   1 
ATOM   3009 C CB  . TRP   B 2 144 ? 141.015 141.964 154.150 1.00 48.93  ? 106 TRP   N CB  1 
ATOM   3010 C CG  . TRP   B 2 144 ? 139.699 141.601 153.555 1.00 50.12  ? 106 TRP   N CG  1 
ATOM   3011 C CD1 . TRP   B 2 144 ? 138.597 142.396 153.456 1.00 48.89  ? 106 TRP   N CD1 1 
ATOM   3012 C CD2 . TRP   B 2 144 ? 139.336 140.338 152.992 1.00 49.28  ? 106 TRP   N CD2 1 
ATOM   3013 N NE1 . TRP   B 2 144 ? 137.571 141.708 152.859 1.00 48.04  ? 106 TRP   N NE1 1 
ATOM   3014 C CE2 . TRP   B 2 144 ? 138.001 140.441 152.563 1.00 49.40  ? 106 TRP   N CE2 1 
ATOM   3015 C CE3 . TRP   B 2 144 ? 140.013 139.131 152.804 1.00 44.91  ? 106 TRP   N CE3 1 
ATOM   3016 C CZ2 . TRP   B 2 144 ? 137.329 139.384 151.959 1.00 49.66  ? 106 TRP   N CZ2 1 
ATOM   3017 C CZ3 . TRP   B 2 144 ? 139.346 138.085 152.204 1.00 47.36  ? 106 TRP   N CZ3 1 
ATOM   3018 C CH2 . TRP   B 2 144 ? 138.017 138.217 151.790 1.00 50.37  ? 106 TRP   N CH2 1 
ATOM   3019 N N   . GLU   B 2 145 ? 142.182 142.461 157.439 1.00 50.54  ? 107 GLU   N N   1 
ATOM   3020 C CA  . GLU   B 2 145 ? 143.237 143.117 158.192 1.00 53.39  ? 107 GLU   N CA  1 
ATOM   3021 C C   . GLU   B 2 145 ? 144.027 142.100 159.008 1.00 54.42  ? 107 GLU   N C   1 
ATOM   3022 O O   . GLU   B 2 145 ? 143.576 140.982 159.262 1.00 59.12  ? 107 GLU   N O   1 
ATOM   3023 C CB  . GLU   B 2 145 ? 142.654 144.191 159.107 1.00 56.23  ? 107 GLU   N CB  1 
ATOM   3024 C CG  . GLU   B 2 145 ? 141.852 145.245 158.369 1.00 61.44  ? 107 GLU   N CG  1 
ATOM   3025 C CD  . GLU   B 2 145 ? 142.683 146.006 157.357 1.00 62.36  ? 107 GLU   N CD  1 
ATOM   3026 O OE1 . GLU   B 2 145 ? 143.856 146.314 157.658 1.00 62.26  ? 107 GLU   N OE1 1 
ATOM   3027 O OE2 . GLU   B 2 145 ? 142.165 146.295 156.258 1.00 59.66  ? 107 GLU   N OE2 1 
ATOM   3028 N N   . GLU   B 2 146 ? 145.222 142.510 159.423 1.00 61.35  ? 108 GLU   N N   1 
ATOM   3029 C CA  . GLU   B 2 146 ? 146.097 141.651 160.204 1.00 63.93  ? 108 GLU   N CA  1 
ATOM   3030 C C   . GLU   B 2 146 ? 145.626 141.595 161.657 1.00 66.89  ? 108 GLU   N C   1 
ATOM   3031 O O   . GLU   B 2 146 ? 144.607 142.179 162.035 1.00 68.09  ? 108 GLU   N O   1 
ATOM   3032 C CB  . GLU   B 2 146 ? 147.537 142.145 160.108 1.00 63.97  ? 108 GLU   N CB  1 
ATOM   3033 C CG  . GLU   B 2 146 ? 147.762 143.504 160.741 1.00 66.60  ? 108 GLU   N CG  1 
ATOM   3034 C CD  . GLU   B 2 146 ? 149.227 143.873 160.824 1.00 69.00  ? 108 GLU   N CD  1 
ATOM   3035 O OE1 . GLU   B 2 146 ? 149.982 143.167 161.526 1.00 67.83  ? 108 GLU   N OE1 1 
ATOM   3036 O OE2 . GLU   B 2 146 ? 149.624 144.871 160.188 1.00 68.23  ? 108 GLU   N OE2 1 
ATOM   3037 N N   . LEU   B 2 147 ? 146.379 140.876 162.485 1.00 63.44  ? 109 LEU   N N   1 
ATOM   3038 C CA  . LEU   B 2 147 ? 146.067 140.736 163.904 1.00 61.73  ? 109 LEU   N CA  1 
ATOM   3039 C C   . LEU   B 2 147 ? 146.652 141.928 164.650 1.00 64.32  ? 109 LEU   N C   1 
ATOM   3040 O O   . LEU   B 2 147 ? 147.868 142.013 164.843 1.00 68.03  ? 109 LEU   N O   1 
ATOM   3041 C CB  . LEU   B 2 147 ? 146.621 139.425 164.451 1.00 64.06  ? 109 LEU   N CB  1 
ATOM   3042 C CG  . LEU   B 2 147 ? 146.281 139.088 165.902 1.00 58.94  ? 109 LEU   N CG  1 
ATOM   3043 C CD1 . LEU   B 2 147 ? 144.855 138.605 166.011 1.00 59.81  ? 109 LEU   N CD1 1 
ATOM   3044 C CD2 . LEU   B 2 147 ? 147.242 138.050 166.448 1.00 60.78  ? 109 LEU   N CD2 1 
ATOM   3045 N N   . LEU   B 2 148 ? 145.789 142.846 165.069 1.00 67.44  ? 110 LEU   N N   1 
ATOM   3046 C CA  . LEU   B 2 148 ? 146.223 144.041 165.775 1.00 67.82  ? 110 LEU   N CA  1 
ATOM   3047 C C   . LEU   B 2 148 ? 146.286 143.782 167.274 1.00 70.41  ? 110 LEU   N C   1 
ATOM   3048 O O   . LEU   B 2 148 ? 145.527 142.977 167.819 1.00 73.09  ? 110 LEU   N O   1 
ATOM   3049 C CB  . LEU   B 2 148 ? 145.283 145.213 165.488 1.00 67.21  ? 110 LEU   N CB  1 
ATOM   3050 C CG  . LEU   B 2 148 ? 145.570 146.077 164.256 1.00 66.80  ? 110 LEU   N CG  1 
ATOM   3051 C CD1 . LEU   B 2 148 ? 146.982 146.642 164.318 1.00 67.67  ? 110 LEU   N CD1 1 
ATOM   3052 C CD2 . LEU   B 2 148 ? 145.345 145.308 162.963 1.00 68.79  ? 110 LEU   N CD2 1 
ATOM   3053 N N   . ASP   B 2 149 ? 147.203 144.479 167.938 1.00 72.54  ? 111 ASP   N N   1 
ATOM   3054 C CA  . ASP   B 2 149 ? 147.420 144.339 169.370 1.00 69.54  ? 111 ASP   N CA  1 
ATOM   3055 C C   . ASP   B 2 149 ? 147.204 145.680 170.055 1.00 66.95  ? 111 ASP   N C   1 
ATOM   3056 O O   . ASP   B 2 149 ? 147.677 146.715 169.575 1.00 70.59  ? 111 ASP   N O   1 
ATOM   3057 C CB  . ASP   B 2 149 ? 148.831 143.822 169.665 1.00 70.24  ? 111 ASP   N CB  1 
ATOM   3058 C CG  . ASP   B 2 149 ? 148.869 142.868 170.839 1.00 70.24  ? 111 ASP   N CG  1 
ATOM   3059 O OD1 . ASP   B 2 149 ? 148.833 143.342 171.993 1.00 70.32  ? 111 ASP   N OD1 1 
ATOM   3060 O OD2 . ASP   B 2 149 ? 148.940 141.643 170.608 1.00 70.45  ? 111 ASP   N OD2 1 
ATOM   3061 N N   . GLY   B 2 150 ? 146.494 145.657 171.183 1.00 70.40  ? 112 GLY   N N   1 
ATOM   3062 C CA  . GLY   B 2 150 ? 146.200 146.860 171.933 1.00 72.41  ? 112 GLY   N CA  1 
ATOM   3063 C C   . GLY   B 2 150 ? 146.619 146.722 173.386 1.00 69.98  ? 112 GLY   N C   1 
ATOM   3064 O O   . GLY   B 2 150 ? 146.945 145.633 173.860 1.00 74.51  ? 112 GLY   N O   1 
ATOM   3065 N N   . TRP   B 2 151 ? 146.602 147.857 174.079 1.00 75.07  ? 113 TRP   N N   1 
ATOM   3066 C CA  . TRP   B 2 151 ? 147.018 147.909 175.471 1.00 79.01  ? 113 TRP   N CA  1 
ATOM   3067 C C   . TRP   B 2 151 ? 146.102 148.867 176.219 1.00 78.40  ? 113 TRP   N C   1 
ATOM   3068 O O   . TRP   B 2 151 ? 145.415 149.698 175.622 1.00 79.25  ? 113 TRP   N O   1 
ATOM   3069 C CB  . TRP   B 2 151 ? 148.487 148.331 175.595 1.00 79.09  ? 113 TRP   N CB  1 
ATOM   3070 C CG  . TRP   B 2 151 ? 149.431 147.176 175.759 1.00 77.52  ? 113 TRP   N CG  1 
ATOM   3071 C CD1 . TRP   B 2 151 ? 149.725 146.221 174.831 1.00 78.95  ? 113 TRP   N CD1 1 
ATOM   3072 C CD2 . TRP   B 2 151 ? 150.215 146.862 176.917 1.00 79.18  ? 113 TRP   N CD2 1 
ATOM   3073 N NE1 . TRP   B 2 151 ? 150.633 145.327 175.340 1.00 78.98  ? 113 TRP   N NE1 1 
ATOM   3074 C CE2 . TRP   B 2 151 ? 150.951 145.699 176.619 1.00 79.80  ? 113 TRP   N CE2 1 
ATOM   3075 C CE3 . TRP   B 2 151 ? 150.362 147.449 178.176 1.00 79.41  ? 113 TRP   N CE3 1 
ATOM   3076 C CZ2 . TRP   B 2 151 ? 151.822 145.113 177.534 1.00 79.54  ? 113 TRP   N CZ2 1 
ATOM   3077 C CZ3 . TRP   B 2 151 ? 151.228 146.866 179.082 1.00 80.55  ? 113 TRP   N CZ3 1 
ATOM   3078 C CH2 . TRP   B 2 151 ? 151.946 145.710 178.757 1.00 81.06  ? 113 TRP   N CH2 1 
ATOM   3079 N N   . GLY   B 2 152 ? 146.095 148.737 177.545 1.00 88.96  ? 114 GLY   N N   1 
ATOM   3080 C CA  . GLY   B 2 152 ? 145.255 149.551 178.393 1.00 90.09  ? 114 GLY   N CA  1 
ATOM   3081 C C   . GLY   B 2 152 ? 145.999 150.731 179.001 1.00 92.68  ? 114 GLY   N C   1 
ATOM   3082 O O   . GLY   B 2 152 ? 147.206 150.892 178.847 1.00 92.92  ? 114 GLY   N O   1 
ATOM   3083 N N   . GLN   B 2 153 ? 145.236 151.565 179.711 1.00 107.76 ? 115 GLN   N N   1 
ATOM   3084 C CA  . GLN   B 2 153 ? 145.798 152.781 180.291 1.00 108.41 ? 115 GLN   N CA  1 
ATOM   3085 C C   . GLN   B 2 153 ? 146.730 152.465 181.454 1.00 106.98 ? 115 GLN   N C   1 
ATOM   3086 O O   . GLN   B 2 153 ? 147.840 153.002 181.538 1.00 107.97 ? 115 GLN   N O   1 
ATOM   3087 C CB  . GLN   B 2 153 ? 144.672 153.711 180.745 1.00 107.89 ? 115 GLN   N CB  1 
ATOM   3088 C CG  . GLN   B 2 153 ? 143.845 154.290 179.609 1.00 108.00 ? 115 GLN   N CG  1 
ATOM   3089 C CD  . GLN   B 2 153 ? 142.950 155.426 180.063 1.00 109.03 ? 115 GLN   N CD  1 
ATOM   3090 O OE1 . GLN   B 2 153 ? 142.821 155.692 181.258 1.00 109.34 ? 115 GLN   N OE1 1 
ATOM   3091 N NE2 . GLN   B 2 153 ? 142.327 156.106 179.107 1.00 107.98 ? 115 GLN   N NE2 1 
ATOM   3092 N N   . GLY   B 2 154 ? 146.296 151.597 182.363 1.00 113.00 ? 116 GLY   N N   1 
ATOM   3093 C CA  . GLY   B 2 154 ? 147.074 151.299 183.549 1.00 115.91 ? 116 GLY   N CA  1 
ATOM   3094 C C   . GLY   B 2 154 ? 146.299 151.554 184.824 1.00 116.93 ? 116 GLY   N C   1 
ATOM   3095 O O   . GLY   B 2 154 ? 145.840 152.674 185.066 1.00 115.66 ? 116 GLY   N O   1 
ATOM   3096 N N   . THR   B 2 155 ? 146.146 150.522 185.649 1.00 126.48 ? 117 THR   N N   1 
ATOM   3097 C CA  . THR   B 2 155 ? 145.373 150.602 186.881 1.00 126.93 ? 117 THR   N CA  1 
ATOM   3098 C C   . THR   B 2 155 ? 146.303 150.430 188.072 1.00 127.67 ? 117 THR   N C   1 
ATOM   3099 O O   . THR   B 2 155 ? 147.098 149.485 188.114 1.00 126.55 ? 117 THR   N O   1 
ATOM   3100 C CB  . THR   B 2 155 ? 144.272 149.538 186.914 1.00 126.80 ? 117 THR   N CB  1 
ATOM   3101 O OG1 . THR   B 2 155 ? 143.311 149.809 185.888 1.00 125.15 ? 117 THR   N OG1 1 
ATOM   3102 C CG2 . THR   B 2 155 ? 143.572 149.535 188.261 1.00 126.35 ? 117 THR   N CG2 1 
ATOM   3103 N N   . GLN   B 2 156 ? 146.202 151.343 189.033 1.00 141.85 ? 118 GLN   N N   1 
ATOM   3104 C CA  . GLN   B 2 156 ? 146.990 151.289 190.256 1.00 142.16 ? 118 GLN   N CA  1 
ATOM   3105 C C   . GLN   B 2 156 ? 146.145 150.705 191.380 1.00 142.60 ? 118 GLN   N C   1 
ATOM   3106 O O   . GLN   B 2 156 ? 145.089 151.250 191.718 1.00 142.38 ? 118 GLN   N O   1 
ATOM   3107 C CB  . GLN   B 2 156 ? 147.495 152.680 190.641 1.00 142.44 ? 118 GLN   N CB  1 
ATOM   3108 C CG  . GLN   B 2 156 ? 147.979 152.790 192.078 1.00 142.87 ? 118 GLN   N CG  1 
ATOM   3109 C CD  . GLN   B 2 156 ? 149.227 151.970 192.338 1.00 143.41 ? 118 GLN   N CD  1 
ATOM   3110 O OE1 . GLN   B 2 156 ? 149.149 150.808 192.738 1.00 143.17 ? 118 GLN   N OE1 1 
ATOM   3111 N NE2 . GLN   B 2 156 ? 150.388 152.573 192.112 1.00 143.33 ? 118 GLN   N NE2 1 
ATOM   3112 N N   . VAL   B 2 157 ? 146.612 149.600 191.954 1.00 145.66 ? 119 VAL   N N   1 
ATOM   3113 C CA  . VAL   B 2 157 ? 145.954 148.948 193.080 1.00 145.57 ? 119 VAL   N CA  1 
ATOM   3114 C C   . VAL   B 2 157 ? 146.919 148.971 194.254 1.00 145.58 ? 119 VAL   N C   1 
ATOM   3115 O O   . VAL   B 2 157 ? 148.041 148.457 194.152 1.00 145.25 ? 119 VAL   N O   1 
ATOM   3116 C CB  . VAL   B 2 157 ? 145.532 147.509 192.744 1.00 145.28 ? 119 VAL   N CB  1 
ATOM   3117 C CG1 . VAL   B 2 157 ? 145.135 146.763 194.009 1.00 144.28 ? 119 VAL   N CG1 1 
ATOM   3118 C CG2 . VAL   B 2 157 ? 144.392 147.511 191.739 1.00 145.34 ? 119 VAL   N CG2 1 
ATOM   3119 N N   . THR   B 2 158 ? 146.488 149.562 195.365 1.00 151.57 ? 120 THR   N N   1 
ATOM   3120 C CA  . THR   B 2 158 ? 147.315 149.705 196.555 1.00 151.93 ? 120 THR   N CA  1 
ATOM   3121 C C   . THR   B 2 158 ? 146.715 148.890 197.690 1.00 151.34 ? 120 THR   N C   1 
ATOM   3122 O O   . THR   B 2 158 ? 145.548 149.078 198.047 1.00 150.40 ? 120 THR   N O   1 
ATOM   3123 C CB  . THR   B 2 158 ? 147.439 151.173 196.971 1.00 150.81 ? 120 THR   N CB  1 
ATOM   3124 O OG1 . THR   B 2 158 ? 146.136 151.711 197.230 1.00 150.32 ? 120 THR   N OG1 1 
ATOM   3125 C CG2 . THR   B 2 158 ? 148.103 151.984 195.869 1.00 150.44 ? 120 THR   N CG2 1 
ATOM   3126 N N   . VAL   B 2 159 ? 147.515 147.988 198.251 1.00 153.39 ? 121 VAL   N N   1 
ATOM   3127 C CA  . VAL   B 2 159 ? 147.132 147.183 199.404 1.00 153.13 ? 121 VAL   N CA  1 
ATOM   3128 C C   . VAL   B 2 159 ? 148.232 147.303 200.448 1.00 153.83 ? 121 VAL   N C   1 
ATOM   3129 O O   . VAL   B 2 159 ? 149.421 147.264 200.109 1.00 154.16 ? 121 VAL   N O   1 
ATOM   3130 C CB  . VAL   B 2 159 ? 146.896 145.710 199.022 1.00 153.31 ? 121 VAL   N CB  1 
ATOM   3131 N N   . SER   B 2 160 ? 147.837 147.460 201.708 1.00 153.83 ? 122 SER   N N   1 
ATOM   3132 C CA  . SER   B 2 160 ? 148.805 147.607 202.785 1.00 153.94 ? 122 SER   N CA  1 
ATOM   3133 C C   . SER   B 2 160 ? 149.627 146.334 202.948 1.00 154.43 ? 122 SER   N C   1 
ATOM   3134 O O   . SER   B 2 160 ? 149.104 145.220 202.862 1.00 153.83 ? 122 SER   N O   1 
ATOM   3135 C CB  . SER   B 2 160 ? 148.096 147.946 204.096 1.00 153.03 ? 122 SER   N CB  1 
ATOM   3136 N N   . SER   B 2 161 ? 150.923 146.507 203.184 1.00 157.15 ? 123 SER   N N   1 
ATOM   3137 C CA  . SER   B 2 161 ? 151.829 145.378 203.356 1.00 156.84 ? 123 SER   N CA  1 
ATOM   3138 C C   . SER   B 2 161 ? 152.552 145.456 204.696 1.00 157.37 ? 123 SER   N C   1 
ATOM   3139 O O   . SER   B 2 161 ? 152.177 144.780 205.655 1.00 157.54 ? 123 SER   N O   1 
ATOM   3140 C CB  . SER   B 2 161 ? 152.842 145.324 202.211 1.00 156.90 ? 123 SER   N CB  1 
HETATM 3141 C C14 . A1D8L C 3 .   ? 125.309 136.856 119.639 1.00 43.17  ? 401 A1D8L R C14 1 
HETATM 3142 C C15 . A1D8L C 3 .   ? 124.032 137.541 119.989 1.00 44.80  ? 401 A1D8L R C15 1 
HETATM 3143 C C16 . A1D8L C 3 .   ? 121.954 137.971 120.337 1.00 40.99  ? 401 A1D8L R C16 1 
HETATM 3144 C C17 . A1D8L C 3 .   ? 120.571 137.951 120.466 1.00 43.36  ? 401 A1D8L R C17 1 
HETATM 3145 C C18 . A1D8L C 3 .   ? 119.941 139.107 120.845 1.00 40.75  ? 401 A1D8L R C18 1 
HETATM 3146 C C19 . A1D8L C 3 .   ? 120.658 140.261 121.108 1.00 37.88  ? 401 A1D8L R C19 1 
HETATM 3147 C C20 . A1D8L C 3 .   ? 122.027 140.295 121.003 1.00 39.74  ? 401 A1D8L R C20 1 
HETATM 3148 C C21 . A1D8L C 3 .   ? 122.659 139.133 120.608 1.00 39.68  ? 401 A1D8L R C21 1 
HETATM 3149 N N2  . A1D8L C 3 .   ? 126.337 137.852 119.358 1.00 39.03  ? 401 A1D8L R N2  1 
HETATM 3150 C C1  . A1D8L C 3 .   ? 129.537 135.867 119.582 1.00 35.75  ? 401 A1D8L R C1  1 
HETATM 3151 C C10 . A1D8L C 3 .   ? 126.282 138.287 117.955 1.00 39.16  ? 401 A1D8L R C10 1 
HETATM 3152 C C11 . A1D8L C 3 .   ? 125.711 137.376 116.894 1.00 38.03  ? 401 A1D8L R C11 1 
HETATM 3153 C C12 . A1D8L C 3 .   ? 126.204 137.818 115.531 1.00 37.86  ? 401 A1D8L R C12 1 
HETATM 3154 C C13 . A1D8L C 3 .   ? 125.289 138.799 114.854 1.00 38.90  ? 401 A1D8L R C13 1 
HETATM 3155 C C2  . A1D8L C 3 .   ? 128.264 136.376 118.941 1.00 37.90  ? 401 A1D8L R C2  1 
HETATM 3156 C C3  . A1D8L C 3 .   ? 127.659 137.454 119.776 1.00 35.82  ? 401 A1D8L R C3  1 
HETATM 3157 C C4  . A1D8L C 3 .   ? 128.612 138.619 119.778 1.00 40.74  ? 401 A1D8L R C4  1 
HETATM 3158 C C5  . A1D8L C 3 .   ? 129.977 138.363 119.759 1.00 44.13  ? 401 A1D8L R C5  1 
HETATM 3159 C C6  . A1D8L C 3 .   ? 130.552 136.969 119.727 1.00 37.75  ? 401 A1D8L R C6  1 
HETATM 3160 C C7  . A1D8L C 3 .   ? 130.831 139.459 119.763 1.00 41.85  ? 401 A1D8L R C7  1 
HETATM 3161 C C8  . A1D8L C 3 .   ? 130.326 140.737 119.773 1.00 37.09  ? 401 A1D8L R C8  1 
HETATM 3162 C C9  . A1D8L C 3 .   ? 128.959 140.884 119.790 1.00 36.47  ? 401 A1D8L R C9  1 
HETATM 3163 N N1  . A1D8L C 3 .   ? 128.116 139.862 119.800 1.00 38.53  ? 401 A1D8L R N1  1 
HETATM 3164 N N3  . A1D8L C 3 .   ? 126.004 139.598 113.872 1.00 36.10  ? 401 A1D8L R N3  1 
HETATM 3165 N N4  . A1D8L C 3 .   ? 122.842 136.973 119.954 1.00 42.00  ? 401 A1D8L R N4  1 
HETATM 3166 N N5  . A1D8L C 3 .   ? 123.980 138.826 120.386 1.00 40.41  ? 401 A1D8L R N5  1 
HETATM 3167 C C1  . CLR   D 4 .   ? 132.931 138.114 150.173 1.00 52.59  ? 402 CLR   R C1  1 
HETATM 3168 C C2  . CLR   D 4 .   ? 133.211 138.502 151.619 1.00 54.58  ? 402 CLR   R C2  1 
HETATM 3169 C C3  . CLR   D 4 .   ? 132.137 139.424 152.154 1.00 52.29  ? 402 CLR   R C3  1 
HETATM 3170 C C4  . CLR   D 4 .   ? 130.766 138.776 151.992 1.00 52.55  ? 402 CLR   R C4  1 
HETATM 3171 C C5  . CLR   D 4 .   ? 130.505 138.354 150.570 1.00 55.65  ? 402 CLR   R C5  1 
HETATM 3172 C C6  . CLR   D 4 .   ? 129.484 138.879 149.895 1.00 52.47  ? 402 CLR   R C6  1 
HETATM 3173 C C7  . CLR   D 4 .   ? 129.092 138.476 148.515 1.00 49.76  ? 402 CLR   R C7  1 
HETATM 3174 C C8  . CLR   D 4 .   ? 129.829 137.222 148.063 1.00 51.94  ? 402 CLR   R C8  1 
HETATM 3175 C C9  . CLR   D 4 .   ? 131.321 137.356 148.396 1.00 49.50  ? 402 CLR   R C9  1 
HETATM 3176 C C10 . CLR   D 4 .   ? 131.555 137.464 149.926 1.00 52.42  ? 402 CLR   R C10 1 
HETATM 3177 C C11 . CLR   D 4 .   ? 132.154 136.256 147.718 1.00 50.73  ? 402 CLR   R C11 1 
HETATM 3178 C C12 . CLR   D 4 .   ? 131.841 136.029 146.232 1.00 53.60  ? 402 CLR   R C12 1 
HETATM 3179 C C13 . CLR   D 4 .   ? 130.353 135.746 146.025 1.00 52.80  ? 402 CLR   R C13 1 
HETATM 3180 C C14 . CLR   D 4 .   ? 129.646 136.997 146.574 1.00 56.16  ? 402 CLR   R C14 1 
HETATM 3181 C C15 . CLR   D 4 .   ? 128.236 136.918 146.014 1.00 53.64  ? 402 CLR   R C15 1 
HETATM 3182 C C16 . CLR   D 4 .   ? 128.527 136.541 144.554 1.00 48.46  ? 402 CLR   R C16 1 
HETATM 3183 C C17 . CLR   D 4 .   ? 129.818 135.671 144.563 1.00 50.15  ? 402 CLR   R C17 1 
HETATM 3184 C C18 . CLR   D 4 .   ? 129.964 134.479 146.787 1.00 45.11  ? 402 CLR   R C18 1 
HETATM 3185 C C19 . CLR   D 4 .   ? 131.510 136.086 150.602 1.00 49.77  ? 402 CLR   R C19 1 
HETATM 3186 C C20 . CLR   D 4 .   ? 129.582 134.287 143.926 1.00 51.75  ? 402 CLR   R C20 1 
HETATM 3187 C C21 . CLR   D 4 .   ? 130.687 133.886 142.953 1.00 50.29  ? 402 CLR   R C21 1 
HETATM 3188 C C22 . CLR   D 4 .   ? 128.195 134.215 143.257 1.00 48.08  ? 402 CLR   R C22 1 
HETATM 3189 C C23 . CLR   D 4 .   ? 128.107 133.481 141.922 1.00 47.90  ? 402 CLR   R C23 1 
HETATM 3190 C C24 . CLR   D 4 .   ? 127.640 132.037 142.073 1.00 51.89  ? 402 CLR   R C24 1 
HETATM 3191 C C25 . CLR   D 4 .   ? 126.175 131.774 141.716 1.00 53.31  ? 402 CLR   R C25 1 
HETATM 3192 C C26 . CLR   D 4 .   ? 125.835 132.407 140.372 1.00 54.57  ? 402 CLR   R C26 1 
HETATM 3193 C C27 . CLR   D 4 .   ? 125.844 130.284 141.688 1.00 45.82  ? 402 CLR   R C27 1 
HETATM 3194 O O1  . CLR   D 4 .   ? 132.425 139.704 153.508 1.00 49.77  ? 402 CLR   R O1  1 
HETATM 3195 C C1  . CLR   E 4 .   ? 134.488 147.712 145.729 1.00 68.01  ? 403 CLR   R C1  1 
HETATM 3196 C C2  . CLR   E 4 .   ? 135.040 147.823 147.149 1.00 70.65  ? 403 CLR   R C2  1 
HETATM 3197 C C3  . CLR   E 4 .   ? 133.959 148.205 148.125 1.00 74.06  ? 403 CLR   R C3  1 
HETATM 3198 C C4  . CLR   E 4 .   ? 132.840 147.187 148.072 1.00 73.75  ? 403 CLR   R C4  1 
HETATM 3199 C C5  . CLR   E 4 .   ? 132.283 147.006 146.679 1.00 74.82  ? 403 CLR   R C5  1 
HETATM 3200 C C6  . CLR   E 4 .   ? 130.975 147.050 146.473 1.00 73.08  ? 403 CLR   R C6  1 
HETATM 3201 C C7  . CLR   E 4 .   ? 130.328 147.189 145.135 1.00 71.94  ? 403 CLR   R C7  1 
HETATM 3202 C C8  . CLR   E 4 .   ? 131.188 146.588 144.030 1.00 72.74  ? 403 CLR   R C8  1 
HETATM 3203 C C9  . CLR   E 4 .   ? 132.668 146.984 144.173 1.00 72.74  ? 403 CLR   R C9  1 
HETATM 3204 C C10 . CLR   E 4 .   ? 133.296 146.737 145.573 1.00 73.73  ? 403 CLR   R C10 1 
HETATM 3205 C C11 . CLR   E 4 .   ? 133.492 146.334 143.055 1.00 72.78  ? 403 CLR   R C11 1 
HETATM 3206 C C12 . CLR   E 4 .   ? 132.948 146.630 141.655 1.00 73.00  ? 403 CLR   R C12 1 
HETATM 3207 C C13 . CLR   E 4 .   ? 131.451 146.337 141.522 1.00 71.55  ? 403 CLR   R C13 1 
HETATM 3208 C C14 . CLR   E 4 .   ? 130.735 147.069 142.663 1.00 71.86  ? 403 CLR   R C14 1 
HETATM 3209 C C15 . CLR   E 4 .   ? 129.257 147.004 142.288 1.00 72.70  ? 403 CLR   R C15 1 
HETATM 3210 C C16 . CLR   E 4 .   ? 129.253 146.936 140.746 1.00 73.83  ? 403 CLR   R C16 1 
HETATM 3211 C C17 . CLR   E 4 .   ? 130.736 146.968 140.297 1.00 70.68  ? 403 CLR   R C17 1 
HETATM 3212 C C18 . CLR   E 4 .   ? 131.155 144.837 141.602 1.00 68.70  ? 403 CLR   R C18 1 
HETATM 3213 C C19 . CLR   E 4 .   ? 133.790 145.288 145.720 1.00 70.99  ? 403 CLR   R C19 1 
HETATM 3214 C C20 . CLR   E 4 .   ? 130.956 146.367 138.899 1.00 65.92  ? 403 CLR   R C20 1 
HETATM 3215 C C21 . CLR   E 4 .   ? 131.967 147.150 138.069 1.00 67.44  ? 403 CLR   R C21 1 
HETATM 3216 C C22 . CLR   E 4 .   ? 129.623 146.260 138.149 1.00 66.71  ? 403 CLR   R C22 1 
HETATM 3217 C C23 . CLR   E 4 .   ? 129.531 147.090 136.903 1.00 72.26  ? 403 CLR   R C23 1 
HETATM 3218 C C24 . CLR   E 4 .   ? 128.368 146.715 136.034 1.00 72.27  ? 403 CLR   R C24 1 
HETATM 3219 C C25 . CLR   E 4 .   ? 128.478 147.139 134.575 1.00 76.35  ? 403 CLR   R C25 1 
HETATM 3220 C C26 . CLR   E 4 .   ? 129.905 147.043 134.078 1.00 71.46  ? 403 CLR   R C26 1 
HETATM 3221 C C27 . CLR   E 4 .   ? 127.549 146.323 133.694 1.00 73.51  ? 403 CLR   R C27 1 
HETATM 3222 O O1  . CLR   E 4 .   ? 134.486 148.252 149.459 1.00 71.75  ? 403 CLR   R O1  1 
# 
