data_8ZPL
# 
_entry.id   8ZPL 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZPL         pdb_00008zpl 10.2210/pdb8zpl/pdb 
WWPDB D_1300048276 ?            ?                   
EMDB  EMD-60348    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-26 ? 
2 'EM metadata'     1 0 2025-02-26 ? 
3 'Additional map'  1 0 2025-02-26 1 
4 FSC               1 0 2025-02-26 ? 
5 'Half map'        1 0 2025-02-26 1 
6 'Half map'        1 0 2025-02-26 2 
7 Image             1 0 2025-02-26 ? 
8 'Primary map'     1 0 2025-02-26 ? 
9 'Structure model' 1 1 2025-04-02 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Additional map'  repository 'Initial release' ? ? 
4 4 FSC               repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 'Half map'        repository 'Initial release' ? ? 
7 7 Image             repository 'Initial release' ? ? 
8 8 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 9 'Structure model' 'Data collection'     
2 9 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 9 'Structure model' citation        
2 9 'Structure model' citation_author 
3 9 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  9 'Structure model' '_citation.country'                 
2  9 'Structure model' '_citation.journal_abbrev'          
3  9 'Structure model' '_citation.journal_id_ASTM'         
4  9 'Structure model' '_citation.journal_id_CSD'          
5  9 'Structure model' '_citation.journal_id_ISSN'         
6  9 'Structure model' '_citation.journal_volume'          
7  9 'Structure model' '_citation.page_first'              
8  9 'Structure model' '_citation.page_last'               
9  9 'Structure model' '_citation.pdbx_database_id_DOI'    
10 9 'Structure model' '_citation.pdbx_database_id_PubMed' 
11 9 'Structure model' '_citation.title'                   
12 9 'Structure model' '_citation.year'                    
13 9 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZPL 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-30 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM strucutre of CXCR4 complexed with antagonist HF51116' 
_pdbx_database_related.db_id          EMD-60348 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              honglihu@cuhk.edu.cn 
_pdbx_contact_author.name_first         Hongli 
_pdbx_contact_author.name_last          Hu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3658-272X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Jiao, H.Z.' 1 ? 
'Hu, H.L.'   2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Proc.Natl.Acad.Sci.USA 
_citation.journal_id_ASTM           PNASA6 
_citation.journal_id_CSD            0040 
_citation.journal_id_ISSN           1091-6490 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            122 
_citation.language                  ? 
_citation.page_first                e2425795122 
_citation.page_last                 e2425795122 
_citation.title                     
'Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1073/pnas.2425795122 
_citation.pdbx_database_id_PubMed   40063796 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sang, X.'  1  0009-0002-6561-2254 
primary 'Jiao, H.'  2  ?                   
primary 'Meng, Q.'  3  ?                   
primary 'Fang, X.'  4  ?                   
primary 'Pan, Q.'   5  ?                   
primary 'Zhou, J.'  6  ?                   
primary 'Qian, T.'  7  ?                   
primary 'Zhang, W.' 8  ?                   
primary 'Xu, Y.'    9  ?                   
primary 'An, J.'    10 ?                   
primary 'Huang, Z.' 11 ?                   
primary 'Hu, H.'    12 0000-0003-3658-272X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Nb6 nanobody' 18665.906 1 ? ? ? ? 
2 polymer     man 'Soluble cytochrome b562,C-X-C chemokine receptor type 4' 55451.062 1 ? ? ? ? 
3 non-polymer syn CHOLESTEROL 386.654   2 ? ? ? ? 
4 non-polymer syn 
;(2S)-N-[[4-[[3-(cyclohexylamino)propylamino]methyl]phenyl]methyl]-5-(diaminomethylideneamino)-2-(pyridin-2-ylmethylamino)pentanamide
;
522.729   1 ? ? ? ? 
# 
_entity_name_com.entity_id   2 
_entity_name_com.name        
;Cytochrome b-562,CXC-R4,CXCR-4,FB22,Fusin,HM89,LCR1,Leukocyte-derived seven transmembrane domain receptor,LESTR,Lipopolysaccharide-associated protein 3,LAP-3,LPS-associated protein 3,NPYRL,Stromal cell-derived factor 1 receptor,SDF-1 receptor
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MLLVNQSHQGFNKEHTSKMVSAIVLYVLLAAAAHSAFAMAQVQLQESGGGLVQAGESLRLSCAASGTIFRLYDMGWYRRV
SGNQRELVASITSGGSTKYGDSVKGRFTISRDNAKNTVYLQMSSLKPEDTAVYYCNAEYRTGIWEELLDGWGQGTQVTVS
SHHHHHHHH
;
;MLLVNQSHQGFNKEHTSKMVSAIVLYVLLAAAAHSAFAMAQVQLQESGGGLVQAGESLRLSCAASGTIFRLYDMGWYRRV
SGNQRELVASITSGGSTKYGDSVKGRFTISRDNAKNTVYLQMSSLKPEDTAVYYCNAEYRTGIWEELLDGWGQGTQVTVS
SHHHHHHHH
;
N ? 
2 'polypeptide(L)' no no 
;MKTIIALSYIFCLVFADYKDDDDKGSADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPD
SPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLLVPRGSMEGISIYTSDNYTEEMGSGDYD
SMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANW
YFGNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD
RYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISRLKSVRLLSGSREKDRNLRRITRPTVILILAFFACWLP
YYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSGRPLEVLFQGPHHHH
HHHHHH
;
;MKTIIALSYIFCLVFADYKDDDDKGSADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPD
SPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLLVPRGSMEGISIYTSDNYTEEMGSGDYD
SMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANW
YFGNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD
RYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISRLKSVRLLSGSREKDRNLRRITRPTVILILAFFACWLP
YYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSGRPLEVLFQGPHHHH
HHHHHH
;
R ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 CHOLESTEROL CLR   
4 
;(2S)-N-[[4-[[3-(cyclohexylamino)propylamino]methyl]phenyl]methyl]-5-(diaminomethylideneamino)-2-(pyridin-2-ylmethylamino)pentanamide
;
A1D8K 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LEU n 
1 3   LEU n 
1 4   VAL n 
1 5   ASN n 
1 6   GLN n 
1 7   SER n 
1 8   HIS n 
1 9   GLN n 
1 10  GLY n 
1 11  PHE n 
1 12  ASN n 
1 13  LYS n 
1 14  GLU n 
1 15  HIS n 
1 16  THR n 
1 17  SER n 
1 18  LYS n 
1 19  MET n 
1 20  VAL n 
1 21  SER n 
1 22  ALA n 
1 23  ILE n 
1 24  VAL n 
1 25  LEU n 
1 26  TYR n 
1 27  VAL n 
1 28  LEU n 
1 29  LEU n 
1 30  ALA n 
1 31  ALA n 
1 32  ALA n 
1 33  ALA n 
1 34  HIS n 
1 35  SER n 
1 36  ALA n 
1 37  PHE n 
1 38  ALA n 
1 39  MET n 
1 40  ALA n 
1 41  GLN n 
1 42  VAL n 
1 43  GLN n 
1 44  LEU n 
1 45  GLN n 
1 46  GLU n 
1 47  SER n 
1 48  GLY n 
1 49  GLY n 
1 50  GLY n 
1 51  LEU n 
1 52  VAL n 
1 53  GLN n 
1 54  ALA n 
1 55  GLY n 
1 56  GLU n 
1 57  SER n 
1 58  LEU n 
1 59  ARG n 
1 60  LEU n 
1 61  SER n 
1 62  CYS n 
1 63  ALA n 
1 64  ALA n 
1 65  SER n 
1 66  GLY n 
1 67  THR n 
1 68  ILE n 
1 69  PHE n 
1 70  ARG n 
1 71  LEU n 
1 72  TYR n 
1 73  ASP n 
1 74  MET n 
1 75  GLY n 
1 76  TRP n 
1 77  TYR n 
1 78  ARG n 
1 79  ARG n 
1 80  VAL n 
1 81  SER n 
1 82  GLY n 
1 83  ASN n 
1 84  GLN n 
1 85  ARG n 
1 86  GLU n 
1 87  LEU n 
1 88  VAL n 
1 89  ALA n 
1 90  SER n 
1 91  ILE n 
1 92  THR n 
1 93  SER n 
1 94  GLY n 
1 95  GLY n 
1 96  SER n 
1 97  THR n 
1 98  LYS n 
1 99  TYR n 
1 100 GLY n 
1 101 ASP n 
1 102 SER n 
1 103 VAL n 
1 104 LYS n 
1 105 GLY n 
1 106 ARG n 
1 107 PHE n 
1 108 THR n 
1 109 ILE n 
1 110 SER n 
1 111 ARG n 
1 112 ASP n 
1 113 ASN n 
1 114 ALA n 
1 115 LYS n 
1 116 ASN n 
1 117 THR n 
1 118 VAL n 
1 119 TYR n 
1 120 LEU n 
1 121 GLN n 
1 122 MET n 
1 123 SER n 
1 124 SER n 
1 125 LEU n 
1 126 LYS n 
1 127 PRO n 
1 128 GLU n 
1 129 ASP n 
1 130 THR n 
1 131 ALA n 
1 132 VAL n 
1 133 TYR n 
1 134 TYR n 
1 135 CYS n 
1 136 ASN n 
1 137 ALA n 
1 138 GLU n 
1 139 TYR n 
1 140 ARG n 
1 141 THR n 
1 142 GLY n 
1 143 ILE n 
1 144 TRP n 
1 145 GLU n 
1 146 GLU n 
1 147 LEU n 
1 148 LEU n 
1 149 ASP n 
1 150 GLY n 
1 151 TRP n 
1 152 GLY n 
1 153 GLN n 
1 154 GLY n 
1 155 THR n 
1 156 GLN n 
1 157 VAL n 
1 158 THR n 
1 159 VAL n 
1 160 SER n 
1 161 SER n 
1 162 HIS n 
1 163 HIS n 
1 164 HIS n 
1 165 HIS n 
1 166 HIS n 
1 167 HIS n 
1 168 HIS n 
1 169 HIS n 
2 1   MET n 
2 2   LYS n 
2 3   THR n 
2 4   ILE n 
2 5   ILE n 
2 6   ALA n 
2 7   LEU n 
2 8   SER n 
2 9   TYR n 
2 10  ILE n 
2 11  PHE n 
2 12  CYS n 
2 13  LEU n 
2 14  VAL n 
2 15  PHE n 
2 16  ALA n 
2 17  ASP n 
2 18  TYR n 
2 19  LYS n 
2 20  ASP n 
2 21  ASP n 
2 22  ASP n 
2 23  ASP n 
2 24  LYS n 
2 25  GLY n 
2 26  SER n 
2 27  ALA n 
2 28  ASP n 
2 29  LEU n 
2 30  GLU n 
2 31  ASP n 
2 32  ASN n 
2 33  TRP n 
2 34  GLU n 
2 35  THR n 
2 36  LEU n 
2 37  ASN n 
2 38  ASP n 
2 39  ASN n 
2 40  LEU n 
2 41  LYS n 
2 42  VAL n 
2 43  ILE n 
2 44  GLU n 
2 45  LYS n 
2 46  ALA n 
2 47  ASP n 
2 48  ASN n 
2 49  ALA n 
2 50  ALA n 
2 51  GLN n 
2 52  VAL n 
2 53  LYS n 
2 54  ASP n 
2 55  ALA n 
2 56  LEU n 
2 57  THR n 
2 58  LYS n 
2 59  MET n 
2 60  ARG n 
2 61  ALA n 
2 62  ALA n 
2 63  ALA n 
2 64  LEU n 
2 65  ASP n 
2 66  ALA n 
2 67  GLN n 
2 68  LYS n 
2 69  ALA n 
2 70  THR n 
2 71  PRO n 
2 72  PRO n 
2 73  LYS n 
2 74  LEU n 
2 75  GLU n 
2 76  ASP n 
2 77  LYS n 
2 78  SER n 
2 79  PRO n 
2 80  ASP n 
2 81  SER n 
2 82  PRO n 
2 83  GLU n 
2 84  MET n 
2 85  LYS n 
2 86  ASP n 
2 87  PHE n 
2 88  ARG n 
2 89  HIS n 
2 90  GLY n 
2 91  PHE n 
2 92  ASP n 
2 93  ILE n 
2 94  LEU n 
2 95  VAL n 
2 96  GLY n 
2 97  GLN n 
2 98  ILE n 
2 99  ASP n 
2 100 ASP n 
2 101 ALA n 
2 102 LEU n 
2 103 LYS n 
2 104 LEU n 
2 105 ALA n 
2 106 ASN n 
2 107 GLU n 
2 108 GLY n 
2 109 LYS n 
2 110 VAL n 
2 111 LYS n 
2 112 GLU n 
2 113 ALA n 
2 114 GLN n 
2 115 ALA n 
2 116 ALA n 
2 117 ALA n 
2 118 GLU n 
2 119 GLN n 
2 120 LEU n 
2 121 LYS n 
2 122 THR n 
2 123 THR n 
2 124 ARG n 
2 125 ASN n 
2 126 ALA n 
2 127 TYR n 
2 128 ILE n 
2 129 GLN n 
2 130 LYS n 
2 131 TYR n 
2 132 LEU n 
2 133 LEU n 
2 134 VAL n 
2 135 PRO n 
2 136 ARG n 
2 137 GLY n 
2 138 SER n 
2 139 MET n 
2 140 GLU n 
2 141 GLY n 
2 142 ILE n 
2 143 SER n 
2 144 ILE n 
2 145 TYR n 
2 146 THR n 
2 147 SER n 
2 148 ASP n 
2 149 ASN n 
2 150 TYR n 
2 151 THR n 
2 152 GLU n 
2 153 GLU n 
2 154 MET n 
2 155 GLY n 
2 156 SER n 
2 157 GLY n 
2 158 ASP n 
2 159 TYR n 
2 160 ASP n 
2 161 SER n 
2 162 MET n 
2 163 LYS n 
2 164 GLU n 
2 165 PRO n 
2 166 CYS n 
2 167 PHE n 
2 168 ARG n 
2 169 GLU n 
2 170 GLU n 
2 171 ASN n 
2 172 ALA n 
2 173 ASN n 
2 174 PHE n 
2 175 ASN n 
2 176 LYS n 
2 177 ILE n 
2 178 PHE n 
2 179 LEU n 
2 180 PRO n 
2 181 THR n 
2 182 ILE n 
2 183 TYR n 
2 184 SER n 
2 185 ILE n 
2 186 ILE n 
2 187 PHE n 
2 188 LEU n 
2 189 THR n 
2 190 GLY n 
2 191 ILE n 
2 192 VAL n 
2 193 GLY n 
2 194 ASN n 
2 195 GLY n 
2 196 LEU n 
2 197 VAL n 
2 198 ILE n 
2 199 LEU n 
2 200 VAL n 
2 201 MET n 
2 202 GLY n 
2 203 TYR n 
2 204 GLN n 
2 205 LYS n 
2 206 LYS n 
2 207 LEU n 
2 208 ARG n 
2 209 SER n 
2 210 MET n 
2 211 THR n 
2 212 ASP n 
2 213 LYS n 
2 214 TYR n 
2 215 ARG n 
2 216 LEU n 
2 217 HIS n 
2 218 LEU n 
2 219 SER n 
2 220 VAL n 
2 221 ALA n 
2 222 ASP n 
2 223 LEU n 
2 224 LEU n 
2 225 PHE n 
2 226 VAL n 
2 227 ILE n 
2 228 THR n 
2 229 LEU n 
2 230 PRO n 
2 231 PHE n 
2 232 TRP n 
2 233 ALA n 
2 234 VAL n 
2 235 ASP n 
2 236 ALA n 
2 237 VAL n 
2 238 ALA n 
2 239 ASN n 
2 240 TRP n 
2 241 TYR n 
2 242 PHE n 
2 243 GLY n 
2 244 ASN n 
2 245 PHE n 
2 246 LEU n 
2 247 CYS n 
2 248 LYS n 
2 249 ALA n 
2 250 VAL n 
2 251 HIS n 
2 252 VAL n 
2 253 ILE n 
2 254 TYR n 
2 255 THR n 
2 256 VAL n 
2 257 ASN n 
2 258 LEU n 
2 259 TYR n 
2 260 SER n 
2 261 SER n 
2 262 VAL n 
2 263 TRP n 
2 264 ILE n 
2 265 LEU n 
2 266 ALA n 
2 267 PHE n 
2 268 ILE n 
2 269 SER n 
2 270 LEU n 
2 271 ASP n 
2 272 ARG n 
2 273 TYR n 
2 274 LEU n 
2 275 ALA n 
2 276 ILE n 
2 277 VAL n 
2 278 HIS n 
2 279 ALA n 
2 280 THR n 
2 281 ASN n 
2 282 SER n 
2 283 GLN n 
2 284 ARG n 
2 285 PRO n 
2 286 ARG n 
2 287 LYS n 
2 288 LEU n 
2 289 LEU n 
2 290 ALA n 
2 291 GLU n 
2 292 LYS n 
2 293 VAL n 
2 294 VAL n 
2 295 TYR n 
2 296 VAL n 
2 297 GLY n 
2 298 VAL n 
2 299 TRP n 
2 300 ILE n 
2 301 PRO n 
2 302 ALA n 
2 303 LEU n 
2 304 LEU n 
2 305 LEU n 
2 306 THR n 
2 307 ILE n 
2 308 PRO n 
2 309 ASP n 
2 310 PHE n 
2 311 ILE n 
2 312 PHE n 
2 313 ALA n 
2 314 ASN n 
2 315 VAL n 
2 316 SER n 
2 317 GLU n 
2 318 ALA n 
2 319 ASP n 
2 320 ASP n 
2 321 ARG n 
2 322 TYR n 
2 323 ILE n 
2 324 CYS n 
2 325 ASP n 
2 326 ARG n 
2 327 PHE n 
2 328 TYR n 
2 329 PRO n 
2 330 ASN n 
2 331 ASP n 
2 332 LEU n 
2 333 TRP n 
2 334 VAL n 
2 335 VAL n 
2 336 VAL n 
2 337 PHE n 
2 338 GLN n 
2 339 PHE n 
2 340 GLN n 
2 341 HIS n 
2 342 ILE n 
2 343 MET n 
2 344 VAL n 
2 345 GLY n 
2 346 LEU n 
2 347 ILE n 
2 348 LEU n 
2 349 PRO n 
2 350 GLY n 
2 351 ILE n 
2 352 VAL n 
2 353 ILE n 
2 354 LEU n 
2 355 SER n 
2 356 CYS n 
2 357 TYR n 
2 358 CYS n 
2 359 ILE n 
2 360 ILE n 
2 361 ILE n 
2 362 SER n 
2 363 ARG n 
2 364 LEU n 
2 365 LYS n 
2 366 SER n 
2 367 VAL n 
2 368 ARG n 
2 369 LEU n 
2 370 LEU n 
2 371 SER n 
2 372 GLY n 
2 373 SER n 
2 374 ARG n 
2 375 GLU n 
2 376 LYS n 
2 377 ASP n 
2 378 ARG n 
2 379 ASN n 
2 380 LEU n 
2 381 ARG n 
2 382 ARG n 
2 383 ILE n 
2 384 THR n 
2 385 ARG n 
2 386 PRO n 
2 387 THR n 
2 388 VAL n 
2 389 ILE n 
2 390 LEU n 
2 391 ILE n 
2 392 LEU n 
2 393 ALA n 
2 394 PHE n 
2 395 PHE n 
2 396 ALA n 
2 397 CYS n 
2 398 TRP n 
2 399 LEU n 
2 400 PRO n 
2 401 TYR n 
2 402 TYR n 
2 403 ILE n 
2 404 GLY n 
2 405 ILE n 
2 406 SER n 
2 407 ILE n 
2 408 ASP n 
2 409 SER n 
2 410 PHE n 
2 411 ILE n 
2 412 LEU n 
2 413 LEU n 
2 414 GLU n 
2 415 ILE n 
2 416 ILE n 
2 417 LYS n 
2 418 GLN n 
2 419 GLY n 
2 420 CYS n 
2 421 GLU n 
2 422 PHE n 
2 423 GLU n 
2 424 ASN n 
2 425 THR n 
2 426 VAL n 
2 427 HIS n 
2 428 LYS n 
2 429 TRP n 
2 430 ILE n 
2 431 SER n 
2 432 ILE n 
2 433 THR n 
2 434 GLU n 
2 435 ALA n 
2 436 LEU n 
2 437 ALA n 
2 438 PHE n 
2 439 PHE n 
2 440 HIS n 
2 441 CYS n 
2 442 CYS n 
2 443 LEU n 
2 444 ASN n 
2 445 PRO n 
2 446 ILE n 
2 447 LEU n 
2 448 TYR n 
2 449 ALA n 
2 450 PHE n 
2 451 LEU n 
2 452 GLY n 
2 453 ALA n 
2 454 LYS n 
2 455 PHE n 
2 456 LYS n 
2 457 THR n 
2 458 SER n 
2 459 ALA n 
2 460 GLN n 
2 461 HIS n 
2 462 ALA n 
2 463 LEU n 
2 464 THR n 
2 465 SER n 
2 466 GLY n 
2 467 ARG n 
2 468 PRO n 
2 469 LEU n 
2 470 GLU n 
2 471 VAL n 
2 472 LEU n 
2 473 PHE n 
2 474 GLN n 
2 475 GLY n 
2 476 PRO n 
2 477 HIS n 
2 478 HIS n 
2 479 HIS n 
2 480 HIS n 
2 481 HIS n 
2 482 HIS n 
2 483 HIS n 
2 484 HIS n 
2 485 HIS n 
2 486 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   169 ?     ? ?     ? ? ? ? ? ? 'Lama glama'       9844 ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 
7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1   138 ?     ? cybC  ? ? ? ? ? ? 'Escherichia coli' 562  ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 
7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 2 sample 'Biological sequence' 139 386 human ? CXCR4 ? ? ? ? ? ? 'Homo sapiens'     9606 ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 
7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 3 sample 'Biological sequence' 387 486 human ? CXCR4 ? ? ? ? ? ? 'Homo sapiens'     9606 ? ? ? ? ? ? ? ? 'Spodoptera frugiperda' 
7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1D8K non-polymer         . 
;(2S)-N-[[4-[[3-(cyclohexylamino)propylamino]methyl]phenyl]methyl]-5-(diaminomethylideneamino)-2-(pyridin-2-ylmethylamino)pentanamide
;
HF51116 'C29 H46 N8 O'   522.729 
ALA   'L-peptide linking' y ALANINE ?       'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE ?       'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE ?       'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ?       'C4 H7 N O4'     133.103 
CLR   non-polymer         . CHOLESTEROL ?       'C27 H46 O'      386.654 
CYS   'L-peptide linking' y CYSTEINE ?       'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE ?       'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ?       'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE ?       'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE ?       'C6 H10 N3 O2 1' 156.162 
ILE   'L-peptide linking' y ISOLEUCINE ?       'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE ?       'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE ?       'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE ?       'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE ?       'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE ?       'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE ?       'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE ?       'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ?       'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE ?       'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE ?       'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -37  ?   ?   ?   N . n 
A 1 2   LEU 2   -36  ?   ?   ?   N . n 
A 1 3   LEU 3   -35  ?   ?   ?   N . n 
A 1 4   VAL 4   -34  ?   ?   ?   N . n 
A 1 5   ASN 5   -33  ?   ?   ?   N . n 
A 1 6   GLN 6   -32  ?   ?   ?   N . n 
A 1 7   SER 7   -31  ?   ?   ?   N . n 
A 1 8   HIS 8   -30  ?   ?   ?   N . n 
A 1 9   GLN 9   -29  ?   ?   ?   N . n 
A 1 10  GLY 10  -28  ?   ?   ?   N . n 
A 1 11  PHE 11  -27  ?   ?   ?   N . n 
A 1 12  ASN 12  -26  ?   ?   ?   N . n 
A 1 13  LYS 13  -25  ?   ?   ?   N . n 
A 1 14  GLU 14  -24  ?   ?   ?   N . n 
A 1 15  HIS 15  -23  ?   ?   ?   N . n 
A 1 16  THR 16  -22  ?   ?   ?   N . n 
A 1 17  SER 17  -21  ?   ?   ?   N . n 
A 1 18  LYS 18  -20  ?   ?   ?   N . n 
A 1 19  MET 19  -19  ?   ?   ?   N . n 
A 1 20  VAL 20  -18  ?   ?   ?   N . n 
A 1 21  SER 21  -17  ?   ?   ?   N . n 
A 1 22  ALA 22  -16  ?   ?   ?   N . n 
A 1 23  ILE 23  -15  ?   ?   ?   N . n 
A 1 24  VAL 24  -14  ?   ?   ?   N . n 
A 1 25  LEU 25  -13  ?   ?   ?   N . n 
A 1 26  TYR 26  -12  ?   ?   ?   N . n 
A 1 27  VAL 27  -11  ?   ?   ?   N . n 
A 1 28  LEU 28  -10  ?   ?   ?   N . n 
A 1 29  LEU 29  -9   ?   ?   ?   N . n 
A 1 30  ALA 30  -8   ?   ?   ?   N . n 
A 1 31  ALA 31  -7   ?   ?   ?   N . n 
A 1 32  ALA 32  -6   ?   ?   ?   N . n 
A 1 33  ALA 33  -5   ?   ?   ?   N . n 
A 1 34  HIS 34  -4   ?   ?   ?   N . n 
A 1 35  SER 35  -3   ?   ?   ?   N . n 
A 1 36  ALA 36  -2   ?   ?   ?   N . n 
A 1 37  PHE 37  -1   ?   ?   ?   N . n 
A 1 38  ALA 38  0    ?   ?   ?   N . n 
A 1 39  MET 39  1    ?   ?   ?   N . n 
A 1 40  ALA 40  2    ?   ?   ?   N . n 
A 1 41  GLN 41  3    3   GLN GLN N . n 
A 1 42  VAL 42  4    4   VAL VAL N . n 
A 1 43  GLN 43  5    5   GLN GLN N . n 
A 1 44  LEU 44  6    6   LEU LEU N . n 
A 1 45  GLN 45  7    7   GLN GLN N . n 
A 1 46  GLU 46  8    8   GLU GLU N . n 
A 1 47  SER 47  9    9   SER SER N . n 
A 1 48  GLY 48  10   10  GLY GLY N . n 
A 1 49  GLY 49  11   11  GLY GLY N . n 
A 1 50  GLY 50  12   12  GLY GLY N . n 
A 1 51  LEU 51  13   13  LEU LEU N . n 
A 1 52  VAL 52  14   14  VAL VAL N . n 
A 1 53  GLN 53  15   15  GLN GLN N . n 
A 1 54  ALA 54  16   16  ALA ALA N . n 
A 1 55  GLY 55  17   17  GLY GLY N . n 
A 1 56  GLU 56  18   18  GLU GLU N . n 
A 1 57  SER 57  19   19  SER SER N . n 
A 1 58  LEU 58  20   20  LEU LEU N . n 
A 1 59  ARG 59  21   21  ARG ARG N . n 
A 1 60  LEU 60  22   22  LEU LEU N . n 
A 1 61  SER 61  23   23  SER SER N . n 
A 1 62  CYS 62  24   24  CYS CYS N . n 
A 1 63  ALA 63  25   25  ALA ALA N . n 
A 1 64  ALA 64  26   26  ALA ALA N . n 
A 1 65  SER 65  27   27  SER SER N . n 
A 1 66  GLY 66  28   28  GLY GLY N . n 
A 1 67  THR 67  29   29  THR THR N . n 
A 1 68  ILE 68  30   30  ILE ILE N . n 
A 1 69  PHE 69  31   31  PHE PHE N . n 
A 1 70  ARG 70  32   32  ARG ARG N . n 
A 1 71  LEU 71  33   33  LEU LEU N . n 
A 1 72  TYR 72  34   34  TYR TYR N . n 
A 1 73  ASP 73  35   35  ASP ASP N . n 
A 1 74  MET 74  36   36  MET MET N . n 
A 1 75  GLY 75  37   37  GLY GLY N . n 
A 1 76  TRP 76  38   38  TRP TRP N . n 
A 1 77  TYR 77  39   39  TYR TYR N . n 
A 1 78  ARG 78  40   40  ARG ARG N . n 
A 1 79  ARG 79  41   ?   ?   ?   N . n 
A 1 80  VAL 80  42   ?   ?   ?   N . n 
A 1 81  SER 81  43   ?   ?   ?   N . n 
A 1 82  GLY 82  44   ?   ?   ?   N . n 
A 1 83  ASN 83  45   ?   ?   ?   N . n 
A 1 84  GLN 84  46   46  GLN GLN N . n 
A 1 85  ARG 85  47   47  ARG ARG N . n 
A 1 86  GLU 86  48   48  GLU GLU N . n 
A 1 87  LEU 87  49   49  LEU LEU N . n 
A 1 88  VAL 88  50   50  VAL VAL N . n 
A 1 89  ALA 89  51   51  ALA ALA N . n 
A 1 90  SER 90  52   52  SER SER N . n 
A 1 91  ILE 91  53   53  ILE ILE N . n 
A 1 92  THR 92  54   54  THR THR N . n 
A 1 93  SER 93  55   55  SER SER N . n 
A 1 94  GLY 94  56   56  GLY GLY N . n 
A 1 95  GLY 95  57   57  GLY GLY N . n 
A 1 96  SER 96  58   58  SER SER N . n 
A 1 97  THR 97  59   59  THR THR N . n 
A 1 98  LYS 98  60   60  LYS LYS N . n 
A 1 99  TYR 99  61   61  TYR TYR N . n 
A 1 100 GLY 100 62   62  GLY GLY N . n 
A 1 101 ASP 101 63   63  ASP ASP N . n 
A 1 102 SER 102 64   64  SER SER N . n 
A 1 103 VAL 103 65   65  VAL VAL N . n 
A 1 104 LYS 104 66   66  LYS LYS N . n 
A 1 105 GLY 105 67   67  GLY GLY N . n 
A 1 106 ARG 106 68   68  ARG ARG N . n 
A 1 107 PHE 107 69   69  PHE PHE N . n 
A 1 108 THR 108 70   70  THR THR N . n 
A 1 109 ILE 109 71   71  ILE ILE N . n 
A 1 110 SER 110 72   72  SER SER N . n 
A 1 111 ARG 111 73   73  ARG ARG N . n 
A 1 112 ASP 112 74   74  ASP ASP N . n 
A 1 113 ASN 113 75   75  ASN ASN N . n 
A 1 114 ALA 114 76   76  ALA ALA N . n 
A 1 115 LYS 115 77   77  LYS LYS N . n 
A 1 116 ASN 116 78   78  ASN ASN N . n 
A 1 117 THR 117 79   79  THR THR N . n 
A 1 118 VAL 118 80   80  VAL VAL N . n 
A 1 119 TYR 119 81   81  TYR TYR N . n 
A 1 120 LEU 120 82   82  LEU LEU N . n 
A 1 121 GLN 121 83   83  GLN GLN N . n 
A 1 122 MET 122 84   84  MET MET N . n 
A 1 123 SER 123 85   85  SER SER N . n 
A 1 124 SER 124 86   86  SER SER N . n 
A 1 125 LEU 125 87   87  LEU LEU N . n 
A 1 126 LYS 126 88   88  LYS LYS N . n 
A 1 127 PRO 127 89   89  PRO PRO N . n 
A 1 128 GLU 128 90   90  GLU GLU N . n 
A 1 129 ASP 129 91   91  ASP ASP N . n 
A 1 130 THR 130 92   92  THR THR N . n 
A 1 131 ALA 131 93   93  ALA ALA N . n 
A 1 132 VAL 132 94   94  VAL VAL N . n 
A 1 133 TYR 133 95   95  TYR TYR N . n 
A 1 134 TYR 134 96   96  TYR TYR N . n 
A 1 135 CYS 135 97   97  CYS CYS N . n 
A 1 136 ASN 136 98   98  ASN ASN N . n 
A 1 137 ALA 137 99   99  ALA ALA N . n 
A 1 138 GLU 138 100  100 GLU GLU N . n 
A 1 139 TYR 139 101  101 TYR TYR N . n 
A 1 140 ARG 140 102  102 ARG ARG N . n 
A 1 141 THR 141 103  103 THR THR N . n 
A 1 142 GLY 142 104  104 GLY GLY N . n 
A 1 143 ILE 143 105  105 ILE ILE N . n 
A 1 144 TRP 144 106  106 TRP TRP N . n 
A 1 145 GLU 145 107  107 GLU GLU N . n 
A 1 146 GLU 146 108  108 GLU GLU N . n 
A 1 147 LEU 147 109  109 LEU LEU N . n 
A 1 148 LEU 148 110  110 LEU LEU N . n 
A 1 149 ASP 149 111  111 ASP ASP N . n 
A 1 150 GLY 150 112  112 GLY GLY N . n 
A 1 151 TRP 151 113  113 TRP TRP N . n 
A 1 152 GLY 152 114  114 GLY GLY N . n 
A 1 153 GLN 153 115  115 GLN GLN N . n 
A 1 154 GLY 154 116  116 GLY GLY N . n 
A 1 155 THR 155 117  117 THR THR N . n 
A 1 156 GLN 156 118  118 GLN GLN N . n 
A 1 157 VAL 157 119  119 VAL VAL N . n 
A 1 158 THR 158 120  120 THR THR N . n 
A 1 159 VAL 159 121  121 VAL VAL N . n 
A 1 160 SER 160 122  122 SER SER N . n 
A 1 161 SER 161 123  123 SER SER N . n 
A 1 162 HIS 162 124  ?   ?   ?   N . n 
A 1 163 HIS 163 125  ?   ?   ?   N . n 
A 1 164 HIS 164 126  ?   ?   ?   N . n 
A 1 165 HIS 165 127  ?   ?   ?   N . n 
A 1 166 HIS 166 128  ?   ?   ?   N . n 
A 1 167 HIS 167 129  ?   ?   ?   N . n 
A 1 168 HIS 168 130  ?   ?   ?   N . n 
A 1 169 HIS 169 131  ?   ?   ?   N . n 
B 2 1   MET 1   -137 ?   ?   ?   R . n 
B 2 2   LYS 2   -136 ?   ?   ?   R . n 
B 2 3   THR 3   -135 ?   ?   ?   R . n 
B 2 4   ILE 4   -134 ?   ?   ?   R . n 
B 2 5   ILE 5   -133 ?   ?   ?   R . n 
B 2 6   ALA 6   -132 ?   ?   ?   R . n 
B 2 7   LEU 7   -131 ?   ?   ?   R . n 
B 2 8   SER 8   -130 ?   ?   ?   R . n 
B 2 9   TYR 9   -129 ?   ?   ?   R . n 
B 2 10  ILE 10  -128 ?   ?   ?   R . n 
B 2 11  PHE 11  -127 ?   ?   ?   R . n 
B 2 12  CYS 12  -126 ?   ?   ?   R . n 
B 2 13  LEU 13  -125 ?   ?   ?   R . n 
B 2 14  VAL 14  -124 ?   ?   ?   R . n 
B 2 15  PHE 15  -123 ?   ?   ?   R . n 
B 2 16  ALA 16  -122 ?   ?   ?   R . n 
B 2 17  ASP 17  -121 ?   ?   ?   R . n 
B 2 18  TYR 18  -120 ?   ?   ?   R . n 
B 2 19  LYS 19  -119 ?   ?   ?   R . n 
B 2 20  ASP 20  -118 ?   ?   ?   R . n 
B 2 21  ASP 21  -117 ?   ?   ?   R . n 
B 2 22  ASP 22  -116 ?   ?   ?   R . n 
B 2 23  ASP 23  -115 ?   ?   ?   R . n 
B 2 24  LYS 24  -114 ?   ?   ?   R . n 
B 2 25  GLY 25  -113 ?   ?   ?   R . n 
B 2 26  SER 26  -112 ?   ?   ?   R . n 
B 2 27  ALA 27  -111 ?   ?   ?   R . n 
B 2 28  ASP 28  -110 ?   ?   ?   R . n 
B 2 29  LEU 29  -109 ?   ?   ?   R . n 
B 2 30  GLU 30  -108 ?   ?   ?   R . n 
B 2 31  ASP 31  -107 ?   ?   ?   R . n 
B 2 32  ASN 32  -106 ?   ?   ?   R . n 
B 2 33  TRP 33  -105 ?   ?   ?   R . n 
B 2 34  GLU 34  -104 ?   ?   ?   R . n 
B 2 35  THR 35  -103 ?   ?   ?   R . n 
B 2 36  LEU 36  -102 ?   ?   ?   R . n 
B 2 37  ASN 37  -101 ?   ?   ?   R . n 
B 2 38  ASP 38  -100 ?   ?   ?   R . n 
B 2 39  ASN 39  -99  ?   ?   ?   R . n 
B 2 40  LEU 40  -98  ?   ?   ?   R . n 
B 2 41  LYS 41  -97  ?   ?   ?   R . n 
B 2 42  VAL 42  -96  ?   ?   ?   R . n 
B 2 43  ILE 43  -95  ?   ?   ?   R . n 
B 2 44  GLU 44  -94  ?   ?   ?   R . n 
B 2 45  LYS 45  -93  ?   ?   ?   R . n 
B 2 46  ALA 46  -92  ?   ?   ?   R . n 
B 2 47  ASP 47  -91  ?   ?   ?   R . n 
B 2 48  ASN 48  -90  ?   ?   ?   R . n 
B 2 49  ALA 49  -89  ?   ?   ?   R . n 
B 2 50  ALA 50  -88  ?   ?   ?   R . n 
B 2 51  GLN 51  -87  ?   ?   ?   R . n 
B 2 52  VAL 52  -86  ?   ?   ?   R . n 
B 2 53  LYS 53  -85  ?   ?   ?   R . n 
B 2 54  ASP 54  -84  ?   ?   ?   R . n 
B 2 55  ALA 55  -83  ?   ?   ?   R . n 
B 2 56  LEU 56  -82  ?   ?   ?   R . n 
B 2 57  THR 57  -81  ?   ?   ?   R . n 
B 2 58  LYS 58  -80  ?   ?   ?   R . n 
B 2 59  MET 59  -79  ?   ?   ?   R . n 
B 2 60  ARG 60  -78  ?   ?   ?   R . n 
B 2 61  ALA 61  -77  ?   ?   ?   R . n 
B 2 62  ALA 62  -76  ?   ?   ?   R . n 
B 2 63  ALA 63  -75  ?   ?   ?   R . n 
B 2 64  LEU 64  -74  ?   ?   ?   R . n 
B 2 65  ASP 65  -73  ?   ?   ?   R . n 
B 2 66  ALA 66  -72  ?   ?   ?   R . n 
B 2 67  GLN 67  -71  ?   ?   ?   R . n 
B 2 68  LYS 68  -70  ?   ?   ?   R . n 
B 2 69  ALA 69  -69  ?   ?   ?   R . n 
B 2 70  THR 70  -68  ?   ?   ?   R . n 
B 2 71  PRO 71  -67  ?   ?   ?   R . n 
B 2 72  PRO 72  -66  ?   ?   ?   R . n 
B 2 73  LYS 73  -65  ?   ?   ?   R . n 
B 2 74  LEU 74  -64  ?   ?   ?   R . n 
B 2 75  GLU 75  -63  ?   ?   ?   R . n 
B 2 76  ASP 76  -62  ?   ?   ?   R . n 
B 2 77  LYS 77  -61  ?   ?   ?   R . n 
B 2 78  SER 78  -60  ?   ?   ?   R . n 
B 2 79  PRO 79  -59  ?   ?   ?   R . n 
B 2 80  ASP 80  -58  ?   ?   ?   R . n 
B 2 81  SER 81  -57  ?   ?   ?   R . n 
B 2 82  PRO 82  -56  ?   ?   ?   R . n 
B 2 83  GLU 83  -55  ?   ?   ?   R . n 
B 2 84  MET 84  -54  ?   ?   ?   R . n 
B 2 85  LYS 85  -53  ?   ?   ?   R . n 
B 2 86  ASP 86  -52  ?   ?   ?   R . n 
B 2 87  PHE 87  -51  ?   ?   ?   R . n 
B 2 88  ARG 88  -50  ?   ?   ?   R . n 
B 2 89  HIS 89  -49  ?   ?   ?   R . n 
B 2 90  GLY 90  -48  ?   ?   ?   R . n 
B 2 91  PHE 91  -47  ?   ?   ?   R . n 
B 2 92  ASP 92  -46  ?   ?   ?   R . n 
B 2 93  ILE 93  -45  ?   ?   ?   R . n 
B 2 94  LEU 94  -44  ?   ?   ?   R . n 
B 2 95  VAL 95  -43  ?   ?   ?   R . n 
B 2 96  GLY 96  -42  ?   ?   ?   R . n 
B 2 97  GLN 97  -41  ?   ?   ?   R . n 
B 2 98  ILE 98  -40  ?   ?   ?   R . n 
B 2 99  ASP 99  -39  ?   ?   ?   R . n 
B 2 100 ASP 100 -38  ?   ?   ?   R . n 
B 2 101 ALA 101 -37  ?   ?   ?   R . n 
B 2 102 LEU 102 -36  ?   ?   ?   R . n 
B 2 103 LYS 103 -35  ?   ?   ?   R . n 
B 2 104 LEU 104 -34  ?   ?   ?   R . n 
B 2 105 ALA 105 -33  ?   ?   ?   R . n 
B 2 106 ASN 106 -32  ?   ?   ?   R . n 
B 2 107 GLU 107 -31  ?   ?   ?   R . n 
B 2 108 GLY 108 -30  ?   ?   ?   R . n 
B 2 109 LYS 109 -29  ?   ?   ?   R . n 
B 2 110 VAL 110 -28  ?   ?   ?   R . n 
B 2 111 LYS 111 -27  ?   ?   ?   R . n 
B 2 112 GLU 112 -26  ?   ?   ?   R . n 
B 2 113 ALA 113 -25  ?   ?   ?   R . n 
B 2 114 GLN 114 -24  ?   ?   ?   R . n 
B 2 115 ALA 115 -23  ?   ?   ?   R . n 
B 2 116 ALA 116 -22  ?   ?   ?   R . n 
B 2 117 ALA 117 -21  ?   ?   ?   R . n 
B 2 118 GLU 118 -20  ?   ?   ?   R . n 
B 2 119 GLN 119 -19  ?   ?   ?   R . n 
B 2 120 LEU 120 -18  ?   ?   ?   R . n 
B 2 121 LYS 121 -17  ?   ?   ?   R . n 
B 2 122 THR 122 -16  ?   ?   ?   R . n 
B 2 123 THR 123 -15  ?   ?   ?   R . n 
B 2 124 ARG 124 -14  ?   ?   ?   R . n 
B 2 125 ASN 125 -13  ?   ?   ?   R . n 
B 2 126 ALA 126 -12  ?   ?   ?   R . n 
B 2 127 TYR 127 -11  ?   ?   ?   R . n 
B 2 128 ILE 128 -10  ?   ?   ?   R . n 
B 2 129 GLN 129 -9   ?   ?   ?   R . n 
B 2 130 LYS 130 -8   ?   ?   ?   R . n 
B 2 131 TYR 131 -7   ?   ?   ?   R . n 
B 2 132 LEU 132 -6   ?   ?   ?   R . n 
B 2 133 LEU 133 -5   ?   ?   ?   R . n 
B 2 134 VAL 134 -4   ?   ?   ?   R . n 
B 2 135 PRO 135 -3   ?   ?   ?   R . n 
B 2 136 ARG 136 -2   ?   ?   ?   R . n 
B 2 137 GLY 137 -1   ?   ?   ?   R . n 
B 2 138 SER 138 0    ?   ?   ?   R . n 
B 2 139 MET 139 1    ?   ?   ?   R . n 
B 2 140 GLU 140 2    ?   ?   ?   R . n 
B 2 141 GLY 141 3    ?   ?   ?   R . n 
B 2 142 ILE 142 4    ?   ?   ?   R . n 
B 2 143 SER 143 5    ?   ?   ?   R . n 
B 2 144 ILE 144 6    ?   ?   ?   R . n 
B 2 145 TYR 145 7    ?   ?   ?   R . n 
B 2 146 THR 146 8    ?   ?   ?   R . n 
B 2 147 SER 147 9    ?   ?   ?   R . n 
B 2 148 ASP 148 10   ?   ?   ?   R . n 
B 2 149 ASN 149 11   ?   ?   ?   R . n 
B 2 150 TYR 150 12   ?   ?   ?   R . n 
B 2 151 THR 151 13   ?   ?   ?   R . n 
B 2 152 GLU 152 14   ?   ?   ?   R . n 
B 2 153 GLU 153 15   ?   ?   ?   R . n 
B 2 154 MET 154 16   ?   ?   ?   R . n 
B 2 155 GLY 155 17   ?   ?   ?   R . n 
B 2 156 SER 156 18   ?   ?   ?   R . n 
B 2 157 GLY 157 19   ?   ?   ?   R . n 
B 2 158 ASP 158 20   ?   ?   ?   R . n 
B 2 159 TYR 159 21   ?   ?   ?   R . n 
B 2 160 ASP 160 22   ?   ?   ?   R . n 
B 2 161 SER 161 23   ?   ?   ?   R . n 
B 2 162 MET 162 24   ?   ?   ?   R . n 
B 2 163 LYS 163 25   ?   ?   ?   R . n 
B 2 164 GLU 164 26   ?   ?   ?   R . n 
B 2 165 PRO 165 27   ?   ?   ?   R . n 
B 2 166 CYS 166 28   ?   ?   ?   R . n 
B 2 167 PHE 167 29   ?   ?   ?   R . n 
B 2 168 ARG 168 30   ?   ?   ?   R . n 
B 2 169 GLU 169 31   ?   ?   ?   R . n 
B 2 170 GLU 170 32   ?   ?   ?   R . n 
B 2 171 ASN 171 33   ?   ?   ?   R . n 
B 2 172 ALA 172 34   34  ALA ALA R . n 
B 2 173 ASN 173 35   35  ASN ASN R . n 
B 2 174 PHE 174 36   36  PHE PHE R . n 
B 2 175 ASN 175 37   37  ASN ASN R . n 
B 2 176 LYS 176 38   38  LYS LYS R . n 
B 2 177 ILE 177 39   39  ILE ILE R . n 
B 2 178 PHE 178 40   40  PHE PHE R . n 
B 2 179 LEU 179 41   41  LEU LEU R . n 
B 2 180 PRO 180 42   42  PRO PRO R . n 
B 2 181 THR 181 43   43  THR THR R . n 
B 2 182 ILE 182 44   44  ILE ILE R . n 
B 2 183 TYR 183 45   45  TYR TYR R . n 
B 2 184 SER 184 46   46  SER SER R . n 
B 2 185 ILE 185 47   47  ILE ILE R . n 
B 2 186 ILE 186 48   48  ILE ILE R . n 
B 2 187 PHE 187 49   49  PHE PHE R . n 
B 2 188 LEU 188 50   50  LEU LEU R . n 
B 2 189 THR 189 51   51  THR THR R . n 
B 2 190 GLY 190 52   52  GLY GLY R . n 
B 2 191 ILE 191 53   53  ILE ILE R . n 
B 2 192 VAL 192 54   54  VAL VAL R . n 
B 2 193 GLY 193 55   55  GLY GLY R . n 
B 2 194 ASN 194 56   56  ASN ASN R . n 
B 2 195 GLY 195 57   57  GLY GLY R . n 
B 2 196 LEU 196 58   58  LEU LEU R . n 
B 2 197 VAL 197 59   59  VAL VAL R . n 
B 2 198 ILE 198 60   60  ILE ILE R . n 
B 2 199 LEU 199 61   61  LEU LEU R . n 
B 2 200 VAL 200 62   62  VAL VAL R . n 
B 2 201 MET 201 63   63  MET MET R . n 
B 2 202 GLY 202 64   64  GLY GLY R . n 
B 2 203 TYR 203 65   65  TYR TYR R . n 
B 2 204 GLN 204 66   66  GLN GLN R . n 
B 2 205 LYS 205 67   67  LYS LYS R . n 
B 2 206 LYS 206 68   68  LYS LYS R . n 
B 2 207 LEU 207 69   69  LEU LEU R . n 
B 2 208 ARG 208 70   70  ARG ARG R . n 
B 2 209 SER 209 71   71  SER SER R . n 
B 2 210 MET 210 72   72  MET MET R . n 
B 2 211 THR 211 73   73  THR THR R . n 
B 2 212 ASP 212 74   74  ASP ASP R . n 
B 2 213 LYS 213 75   75  LYS LYS R . n 
B 2 214 TYR 214 76   76  TYR TYR R . n 
B 2 215 ARG 215 77   77  ARG ARG R . n 
B 2 216 LEU 216 78   78  LEU LEU R . n 
B 2 217 HIS 217 79   79  HIS HIS R . n 
B 2 218 LEU 218 80   80  LEU LEU R . n 
B 2 219 SER 219 81   81  SER SER R . n 
B 2 220 VAL 220 82   82  VAL VAL R . n 
B 2 221 ALA 221 83   83  ALA ALA R . n 
B 2 222 ASP 222 84   84  ASP ASP R . n 
B 2 223 LEU 223 85   85  LEU LEU R . n 
B 2 224 LEU 224 86   86  LEU LEU R . n 
B 2 225 PHE 225 87   87  PHE PHE R . n 
B 2 226 VAL 226 88   88  VAL VAL R . n 
B 2 227 ILE 227 89   89  ILE ILE R . n 
B 2 228 THR 228 90   90  THR THR R . n 
B 2 229 LEU 229 91   91  LEU LEU R . n 
B 2 230 PRO 230 92   92  PRO PRO R . n 
B 2 231 PHE 231 93   93  PHE PHE R . n 
B 2 232 TRP 232 94   94  TRP TRP R . n 
B 2 233 ALA 233 95   95  ALA ALA R . n 
B 2 234 VAL 234 96   96  VAL VAL R . n 
B 2 235 ASP 235 97   97  ASP ASP R . n 
B 2 236 ALA 236 98   98  ALA ALA R . n 
B 2 237 VAL 237 99   99  VAL VAL R . n 
B 2 238 ALA 238 100  100 ALA ALA R . n 
B 2 239 ASN 239 101  101 ASN ASN R . n 
B 2 240 TRP 240 102  102 TRP TRP R . n 
B 2 241 TYR 241 103  103 TYR TYR R . n 
B 2 242 PHE 242 104  104 PHE PHE R . n 
B 2 243 GLY 243 105  105 GLY GLY R . n 
B 2 244 ASN 244 106  106 ASN ASN R . n 
B 2 245 PHE 245 107  107 PHE PHE R . n 
B 2 246 LEU 246 108  108 LEU LEU R . n 
B 2 247 CYS 247 109  109 CYS CYS R . n 
B 2 248 LYS 248 110  110 LYS LYS R . n 
B 2 249 ALA 249 111  111 ALA ALA R . n 
B 2 250 VAL 250 112  112 VAL VAL R . n 
B 2 251 HIS 251 113  113 HIS HIS R . n 
B 2 252 VAL 252 114  114 VAL VAL R . n 
B 2 253 ILE 253 115  115 ILE ILE R . n 
B 2 254 TYR 254 116  116 TYR TYR R . n 
B 2 255 THR 255 117  117 THR THR R . n 
B 2 256 VAL 256 118  118 VAL VAL R . n 
B 2 257 ASN 257 119  119 ASN ASN R . n 
B 2 258 LEU 258 120  120 LEU LEU R . n 
B 2 259 TYR 259 121  121 TYR TYR R . n 
B 2 260 SER 260 122  122 SER SER R . n 
B 2 261 SER 261 123  123 SER SER R . n 
B 2 262 VAL 262 124  124 VAL VAL R . n 
B 2 263 TRP 263 125  125 TRP TRP R . n 
B 2 264 ILE 264 126  126 ILE ILE R . n 
B 2 265 LEU 265 127  127 LEU LEU R . n 
B 2 266 ALA 266 128  128 ALA ALA R . n 
B 2 267 PHE 267 129  129 PHE PHE R . n 
B 2 268 ILE 268 130  130 ILE ILE R . n 
B 2 269 SER 269 131  131 SER SER R . n 
B 2 270 LEU 270 132  132 LEU LEU R . n 
B 2 271 ASP 271 133  133 ASP ASP R . n 
B 2 272 ARG 272 134  134 ARG ARG R . n 
B 2 273 TYR 273 135  135 TYR TYR R . n 
B 2 274 LEU 274 136  136 LEU LEU R . n 
B 2 275 ALA 275 137  137 ALA ALA R . n 
B 2 276 ILE 276 138  138 ILE ILE R . n 
B 2 277 VAL 277 139  139 VAL VAL R . n 
B 2 278 HIS 278 140  140 HIS HIS R . n 
B 2 279 ALA 279 141  141 ALA ALA R . n 
B 2 280 THR 280 142  142 THR THR R . n 
B 2 281 ASN 281 143  143 ASN ASN R . n 
B 2 282 SER 282 144  144 SER SER R . n 
B 2 283 GLN 283 145  145 GLN GLN R . n 
B 2 284 ARG 284 146  146 ARG ARG R . n 
B 2 285 PRO 285 147  147 PRO PRO R . n 
B 2 286 ARG 286 148  148 ARG ARG R . n 
B 2 287 LYS 287 149  149 LYS LYS R . n 
B 2 288 LEU 288 150  150 LEU LEU R . n 
B 2 289 LEU 289 151  151 LEU LEU R . n 
B 2 290 ALA 290 152  152 ALA ALA R . n 
B 2 291 GLU 291 153  153 GLU GLU R . n 
B 2 292 LYS 292 154  154 LYS LYS R . n 
B 2 293 VAL 293 155  155 VAL VAL R . n 
B 2 294 VAL 294 156  156 VAL VAL R . n 
B 2 295 TYR 295 157  157 TYR TYR R . n 
B 2 296 VAL 296 158  158 VAL VAL R . n 
B 2 297 GLY 297 159  159 GLY GLY R . n 
B 2 298 VAL 298 160  160 VAL VAL R . n 
B 2 299 TRP 299 161  161 TRP TRP R . n 
B 2 300 ILE 300 162  162 ILE ILE R . n 
B 2 301 PRO 301 163  163 PRO PRO R . n 
B 2 302 ALA 302 164  164 ALA ALA R . n 
B 2 303 LEU 303 165  165 LEU LEU R . n 
B 2 304 LEU 304 166  166 LEU LEU R . n 
B 2 305 LEU 305 167  167 LEU LEU R . n 
B 2 306 THR 306 168  168 THR THR R . n 
B 2 307 ILE 307 169  169 ILE ILE R . n 
B 2 308 PRO 308 170  170 PRO PRO R . n 
B 2 309 ASP 309 171  171 ASP ASP R . n 
B 2 310 PHE 310 172  172 PHE PHE R . n 
B 2 311 ILE 311 173  173 ILE ILE R . n 
B 2 312 PHE 312 174  174 PHE PHE R . n 
B 2 313 ALA 313 175  175 ALA ALA R . n 
B 2 314 ASN 314 176  176 ASN ASN R . n 
B 2 315 VAL 315 177  177 VAL VAL R . n 
B 2 316 SER 316 178  178 SER SER R . n 
B 2 317 GLU 317 179  179 GLU GLU R . n 
B 2 318 ALA 318 180  180 ALA ALA R . n 
B 2 319 ASP 319 181  181 ASP ASP R . n 
B 2 320 ASP 320 182  182 ASP ASP R . n 
B 2 321 ARG 321 183  183 ARG ARG R . n 
B 2 322 TYR 322 184  184 TYR TYR R . n 
B 2 323 ILE 323 185  185 ILE ILE R . n 
B 2 324 CYS 324 186  186 CYS CYS R . n 
B 2 325 ASP 325 187  187 ASP ASP R . n 
B 2 326 ARG 326 188  188 ARG ARG R . n 
B 2 327 PHE 327 189  189 PHE PHE R . n 
B 2 328 TYR 328 190  190 TYR TYR R . n 
B 2 329 PRO 329 191  191 PRO PRO R . n 
B 2 330 ASN 330 192  192 ASN ASN R . n 
B 2 331 ASP 331 193  193 ASP ASP R . n 
B 2 332 LEU 332 194  194 LEU LEU R . n 
B 2 333 TRP 333 195  195 TRP TRP R . n 
B 2 334 VAL 334 196  196 VAL VAL R . n 
B 2 335 VAL 335 197  197 VAL VAL R . n 
B 2 336 VAL 336 198  198 VAL VAL R . n 
B 2 337 PHE 337 199  199 PHE PHE R . n 
B 2 338 GLN 338 200  200 GLN GLN R . n 
B 2 339 PHE 339 201  201 PHE PHE R . n 
B 2 340 GLN 340 202  202 GLN GLN R . n 
B 2 341 HIS 341 203  203 HIS HIS R . n 
B 2 342 ILE 342 204  204 ILE ILE R . n 
B 2 343 MET 343 205  205 MET MET R . n 
B 2 344 VAL 344 206  206 VAL VAL R . n 
B 2 345 GLY 345 207  207 GLY GLY R . n 
B 2 346 LEU 346 208  208 LEU LEU R . n 
B 2 347 ILE 347 209  209 ILE ILE R . n 
B 2 348 LEU 348 210  210 LEU LEU R . n 
B 2 349 PRO 349 211  211 PRO PRO R . n 
B 2 350 GLY 350 212  212 GLY GLY R . n 
B 2 351 ILE 351 213  213 ILE ILE R . n 
B 2 352 VAL 352 214  214 VAL VAL R . n 
B 2 353 ILE 353 215  215 ILE ILE R . n 
B 2 354 LEU 354 216  216 LEU LEU R . n 
B 2 355 SER 355 217  217 SER SER R . n 
B 2 356 CYS 356 218  218 CYS CYS R . n 
B 2 357 TYR 357 219  219 TYR TYR R . n 
B 2 358 CYS 358 220  220 CYS CYS R . n 
B 2 359 ILE 359 221  221 ILE ILE R . n 
B 2 360 ILE 360 222  222 ILE ILE R . n 
B 2 361 ILE 361 223  223 ILE ILE R . n 
B 2 362 SER 362 224  224 SER SER R . n 
B 2 363 ARG 363 225  225 ARG ARG R . n 
B 2 364 LEU 364 226  226 LEU LEU R . n 
B 2 365 LYS 365 227  227 LYS LYS R . n 
B 2 366 SER 366 228  228 SER SER R . n 
B 2 367 VAL 367 229  229 VAL VAL R . n 
B 2 368 ARG 368 230  230 ARG ARG R . n 
B 2 369 LEU 369 231  231 LEU LEU R . n 
B 2 370 LEU 370 232  232 LEU LEU R . n 
B 2 371 SER 371 233  233 SER SER R . n 
B 2 372 GLY 372 234  234 GLY GLY R . n 
B 2 373 SER 373 235  235 SER SER R . n 
B 2 374 ARG 374 236  236 ARG ARG R . n 
B 2 375 GLU 375 237  237 GLU GLU R . n 
B 2 376 LYS 376 238  238 LYS LYS R . n 
B 2 377 ASP 377 239  239 ASP ASP R . n 
B 2 378 ARG 378 240  240 ARG ARG R . n 
B 2 379 ASN 379 241  241 ASN ASN R . n 
B 2 380 LEU 380 242  242 LEU LEU R . n 
B 2 381 ARG 381 243  243 ARG ARG R . n 
B 2 382 ARG 382 244  244 ARG ARG R . n 
B 2 383 ILE 383 245  245 ILE ILE R . n 
B 2 384 THR 384 246  246 THR THR R . n 
B 2 385 ARG 385 247  247 ARG ARG R . n 
B 2 386 PRO 386 248  248 PRO PRO R . n 
B 2 387 THR 387 249  249 THR THR R . n 
B 2 388 VAL 388 250  250 VAL VAL R . n 
B 2 389 ILE 389 251  251 ILE ILE R . n 
B 2 390 LEU 390 252  252 LEU LEU R . n 
B 2 391 ILE 391 253  253 ILE ILE R . n 
B 2 392 LEU 392 254  254 LEU LEU R . n 
B 2 393 ALA 393 255  255 ALA ALA R . n 
B 2 394 PHE 394 256  256 PHE PHE R . n 
B 2 395 PHE 395 257  257 PHE PHE R . n 
B 2 396 ALA 396 258  258 ALA ALA R . n 
B 2 397 CYS 397 259  259 CYS CYS R . n 
B 2 398 TRP 398 260  260 TRP TRP R . n 
B 2 399 LEU 399 261  261 LEU LEU R . n 
B 2 400 PRO 400 262  262 PRO PRO R . n 
B 2 401 TYR 401 263  263 TYR TYR R . n 
B 2 402 TYR 402 264  264 TYR TYR R . n 
B 2 403 ILE 403 265  265 ILE ILE R . n 
B 2 404 GLY 404 266  266 GLY GLY R . n 
B 2 405 ILE 405 267  267 ILE ILE R . n 
B 2 406 SER 406 268  268 SER SER R . n 
B 2 407 ILE 407 269  269 ILE ILE R . n 
B 2 408 ASP 408 270  270 ASP ASP R . n 
B 2 409 SER 409 271  271 SER SER R . n 
B 2 410 PHE 410 272  272 PHE PHE R . n 
B 2 411 ILE 411 273  273 ILE ILE R . n 
B 2 412 LEU 412 274  274 LEU LEU R . n 
B 2 413 LEU 413 275  275 LEU LEU R . n 
B 2 414 GLU 414 276  276 GLU GLU R . n 
B 2 415 ILE 415 277  277 ILE ILE R . n 
B 2 416 ILE 416 278  278 ILE ILE R . n 
B 2 417 LYS 417 279  279 LYS LYS R . n 
B 2 418 GLN 418 280  280 GLN GLN R . n 
B 2 419 GLY 419 281  281 GLY GLY R . n 
B 2 420 CYS 420 282  282 CYS CYS R . n 
B 2 421 GLU 421 283  283 GLU GLU R . n 
B 2 422 PHE 422 284  284 PHE PHE R . n 
B 2 423 GLU 423 285  285 GLU GLU R . n 
B 2 424 ASN 424 286  286 ASN ASN R . n 
B 2 425 THR 425 287  287 THR THR R . n 
B 2 426 VAL 426 288  288 VAL VAL R . n 
B 2 427 HIS 427 289  289 HIS HIS R . n 
B 2 428 LYS 428 290  290 LYS LYS R . n 
B 2 429 TRP 429 291  291 TRP TRP R . n 
B 2 430 ILE 430 292  292 ILE ILE R . n 
B 2 431 SER 431 293  293 SER SER R . n 
B 2 432 ILE 432 294  294 ILE ILE R . n 
B 2 433 THR 433 295  295 THR THR R . n 
B 2 434 GLU 434 296  296 GLU GLU R . n 
B 2 435 ALA 435 297  297 ALA ALA R . n 
B 2 436 LEU 436 298  298 LEU LEU R . n 
B 2 437 ALA 437 299  299 ALA ALA R . n 
B 2 438 PHE 438 300  300 PHE PHE R . n 
B 2 439 PHE 439 301  301 PHE PHE R . n 
B 2 440 HIS 440 302  302 HIS HIS R . n 
B 2 441 CYS 441 303  303 CYS CYS R . n 
B 2 442 CYS 442 304  304 CYS CYS R . n 
B 2 443 LEU 443 305  305 LEU LEU R . n 
B 2 444 ASN 444 306  306 ASN ASN R . n 
B 2 445 PRO 445 307  307 PRO PRO R . n 
B 2 446 ILE 446 308  308 ILE ILE R . n 
B 2 447 LEU 447 309  309 LEU LEU R . n 
B 2 448 TYR 448 310  310 TYR TYR R . n 
B 2 449 ALA 449 311  311 ALA ALA R . n 
B 2 450 PHE 450 312  312 PHE PHE R . n 
B 2 451 LEU 451 313  313 LEU LEU R . n 
B 2 452 GLY 452 314  314 GLY GLY R . n 
B 2 453 ALA 453 315  315 ALA ALA R . n 
B 2 454 LYS 454 316  ?   ?   ?   R . n 
B 2 455 PHE 455 317  ?   ?   ?   R . n 
B 2 456 LYS 456 318  ?   ?   ?   R . n 
B 2 457 THR 457 319  ?   ?   ?   R . n 
B 2 458 SER 458 320  ?   ?   ?   R . n 
B 2 459 ALA 459 321  ?   ?   ?   R . n 
B 2 460 GLN 460 322  ?   ?   ?   R . n 
B 2 461 HIS 461 323  ?   ?   ?   R . n 
B 2 462 ALA 462 324  ?   ?   ?   R . n 
B 2 463 LEU 463 325  ?   ?   ?   R . n 
B 2 464 THR 464 326  ?   ?   ?   R . n 
B 2 465 SER 465 327  ?   ?   ?   R . n 
B 2 466 GLY 466 328  ?   ?   ?   R . n 
B 2 467 ARG 467 329  ?   ?   ?   R . n 
B 2 468 PRO 468 330  ?   ?   ?   R . n 
B 2 469 LEU 469 331  ?   ?   ?   R . n 
B 2 470 GLU 470 332  ?   ?   ?   R . n 
B 2 471 VAL 471 333  ?   ?   ?   R . n 
B 2 472 LEU 472 334  ?   ?   ?   R . n 
B 2 473 PHE 473 335  ?   ?   ?   R . n 
B 2 474 GLN 474 336  ?   ?   ?   R . n 
B 2 475 GLY 475 337  ?   ?   ?   R . n 
B 2 476 PRO 476 338  ?   ?   ?   R . n 
B 2 477 HIS 477 339  ?   ?   ?   R . n 
B 2 478 HIS 478 340  ?   ?   ?   R . n 
B 2 479 HIS 479 341  ?   ?   ?   R . n 
B 2 480 HIS 480 342  ?   ?   ?   R . n 
B 2 481 HIS 481 343  ?   ?   ?   R . n 
B 2 482 HIS 482 344  ?   ?   ?   R . n 
B 2 483 HIS 483 345  ?   ?   ?   R . n 
B 2 484 HIS 484 346  ?   ?   ?   R . n 
B 2 485 HIS 485 347  ?   ?   ?   R . n 
B 2 486 HIS 486 348  ?   ?   ?   R . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1D8K 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1D8K 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 CLR   1 401 402 CLR   CLR R . 
D 3 CLR   1 402 403 CLR   CLR R . 
E 4 A1D8K 1 403 1   A1D8K HF5 R . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 N GLN 3   ? CG  ? A GLN 41  CG  
2  1 Y 1 N GLN 3   ? CD  ? A GLN 41  CD  
3  1 Y 1 N GLN 3   ? OE1 ? A GLN 41  OE1 
4  1 Y 1 N GLN 3   ? NE2 ? A GLN 41  NE2 
5  1 Y 1 N GLN 5   ? CG  ? A GLN 43  CG  
6  1 Y 1 N GLN 5   ? CD  ? A GLN 43  CD  
7  1 Y 1 N GLN 5   ? OE1 ? A GLN 43  OE1 
8  1 Y 1 N GLN 5   ? NE2 ? A GLN 43  NE2 
9  1 Y 1 N LEU 13  ? CG  ? A LEU 51  CG  
10 1 Y 1 N LEU 13  ? CD1 ? A LEU 51  CD1 
11 1 Y 1 N LEU 13  ? CD2 ? A LEU 51  CD2 
12 1 Y 1 N GLN 15  ? CG  ? A GLN 53  CG  
13 1 Y 1 N GLN 15  ? CD  ? A GLN 53  CD  
14 1 Y 1 N GLN 15  ? OE1 ? A GLN 53  OE1 
15 1 Y 1 N GLN 15  ? NE2 ? A GLN 53  NE2 
16 1 Y 1 N SER 27  ? OG  ? A SER 65  OG  
17 1 Y 1 N LEU 49  ? CG  ? A LEU 87  CG  
18 1 Y 1 N LEU 49  ? CD1 ? A LEU 87  CD1 
19 1 Y 1 N LEU 49  ? CD2 ? A LEU 87  CD2 
20 1 Y 1 N SER 52  ? OG  ? A SER 90  OG  
21 1 Y 1 N SER 58  ? OG  ? A SER 96  OG  
22 1 Y 1 N LYS 60  ? CG  ? A LYS 98  CG  
23 1 Y 1 N LYS 60  ? CD  ? A LYS 98  CD  
24 1 Y 1 N LYS 60  ? CE  ? A LYS 98  CE  
25 1 Y 1 N LYS 60  ? NZ  ? A LYS 98  NZ  
26 1 Y 1 N ASP 63  ? CG  ? A ASP 101 CG  
27 1 Y 1 N ASP 63  ? OD1 ? A ASP 101 OD1 
28 1 Y 1 N ASP 63  ? OD2 ? A ASP 101 OD2 
29 1 Y 1 N SER 64  ? OG  ? A SER 102 OG  
30 1 Y 1 N VAL 65  ? CG1 ? A VAL 103 CG1 
31 1 Y 1 N VAL 65  ? CG2 ? A VAL 103 CG2 
32 1 Y 1 N LYS 66  ? CG  ? A LYS 104 CG  
33 1 Y 1 N LYS 66  ? CD  ? A LYS 104 CD  
34 1 Y 1 N LYS 66  ? CE  ? A LYS 104 CE  
35 1 Y 1 N LYS 66  ? NZ  ? A LYS 104 NZ  
36 1 Y 1 N LYS 77  ? CG  ? A LYS 115 CG  
37 1 Y 1 N LYS 77  ? CD  ? A LYS 115 CD  
38 1 Y 1 N LYS 77  ? CE  ? A LYS 115 CE  
39 1 Y 1 N LYS 77  ? NZ  ? A LYS 115 NZ  
40 1 Y 1 N LYS 88  ? CG  ? A LYS 126 CG  
41 1 Y 1 N LYS 88  ? CD  ? A LYS 126 CD  
42 1 Y 1 N LYS 88  ? CE  ? A LYS 126 CE  
43 1 Y 1 N LYS 88  ? NZ  ? A LYS 126 NZ  
44 1 Y 1 N VAL 121 ? CG1 ? A VAL 159 CG1 
45 1 Y 1 N VAL 121 ? CG2 ? A VAL 159 CG2 
46 1 Y 1 N SER 122 ? OG  ? A SER 160 OG  
47 1 Y 1 N SER 123 ? OG  ? A SER 161 OG  
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZPL 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZPL 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZPL 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8ZPL 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003 ? 3319 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.523 ? 4526 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 7.034 ? 492  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.040 ? 524  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004 ? 544  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8ZPL 
_struct.title                        'Cryo-EM strucutre of CXCR4 complexed with antagonist HF51116' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZPL 
_struct_keywords.text            'CXC motif chemokine receptor 4, antagonist, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8ZPL        8ZPL   ? 1 ? 1   
2 UNP C562_ECOLX  P0ABE7 ? 2 
;ADLEDNMETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLAN
EGKVKEAQAAAEQLKTTRNAYHQKY
;
23  
3 UNP CXCR4_HUMAN P61073 ? 2 
;MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHL
SVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGV
WIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIIS
;
1   
4 UNP CXCR4_HUMAN P61073 ? 2 TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTS 241 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZPL N 1   ? 169 ? 8ZPL   -37 ? 131 ? -37  131 
2 2 8ZPL R 27  ? 131 ? P0ABE7 23  ? 127 ? -111 -7  
3 3 8ZPL R 139 ? 362 ? P61073 1   ? 224 ? 1    224 
4 4 8ZPL R 387 ? 465 ? P61073 241 ? 319 ? 249  327 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
2 8ZPL MET R 1   ? UNP P0ABE7 ?   ?   'initiating methionine' -137 1  
2 8ZPL LYS R 2   ? UNP P0ABE7 ?   ?   'expression tag'        -136 2  
2 8ZPL THR R 3   ? UNP P0ABE7 ?   ?   'expression tag'        -135 3  
2 8ZPL ILE R 4   ? UNP P0ABE7 ?   ?   'expression tag'        -134 4  
2 8ZPL ILE R 5   ? UNP P0ABE7 ?   ?   'expression tag'        -133 5  
2 8ZPL ALA R 6   ? UNP P0ABE7 ?   ?   'expression tag'        -132 6  
2 8ZPL LEU R 7   ? UNP P0ABE7 ?   ?   'expression tag'        -131 7  
2 8ZPL SER R 8   ? UNP P0ABE7 ?   ?   'expression tag'        -130 8  
2 8ZPL TYR R 9   ? UNP P0ABE7 ?   ?   'expression tag'        -129 9  
2 8ZPL ILE R 10  ? UNP P0ABE7 ?   ?   'expression tag'        -128 10 
2 8ZPL PHE R 11  ? UNP P0ABE7 ?   ?   'expression tag'        -127 11 
2 8ZPL CYS R 12  ? UNP P0ABE7 ?   ?   'expression tag'        -126 12 
2 8ZPL LEU R 13  ? UNP P0ABE7 ?   ?   'expression tag'        -125 13 
2 8ZPL VAL R 14  ? UNP P0ABE7 ?   ?   'expression tag'        -124 14 
2 8ZPL PHE R 15  ? UNP P0ABE7 ?   ?   'expression tag'        -123 15 
2 8ZPL ALA R 16  ? UNP P0ABE7 ?   ?   'expression tag'        -122 16 
2 8ZPL ASP R 17  ? UNP P0ABE7 ?   ?   'expression tag'        -121 17 
2 8ZPL TYR R 18  ? UNP P0ABE7 ?   ?   'expression tag'        -120 18 
2 8ZPL LYS R 19  ? UNP P0ABE7 ?   ?   'expression tag'        -119 19 
2 8ZPL ASP R 20  ? UNP P0ABE7 ?   ?   'expression tag'        -118 20 
2 8ZPL ASP R 21  ? UNP P0ABE7 ?   ?   'expression tag'        -117 21 
2 8ZPL ASP R 22  ? UNP P0ABE7 ?   ?   'expression tag'        -116 22 
2 8ZPL ASP R 23  ? UNP P0ABE7 ?   ?   'expression tag'        -115 23 
2 8ZPL LYS R 24  ? UNP P0ABE7 ?   ?   'expression tag'        -114 24 
2 8ZPL GLY R 25  ? UNP P0ABE7 ?   ?   'expression tag'        -113 25 
2 8ZPL SER R 26  ? UNP P0ABE7 ?   ?   'expression tag'        -112 26 
2 8ZPL TRP R 33  ? UNP P0ABE7 MET 29  conflict                -105 27 
2 8ZPL ILE R 128 ? UNP P0ABE7 HIS 124 conflict                -10  28 
2 8ZPL LEU R 132 ? UNP P0ABE7 ?   ?   linker                  -6   29 
2 8ZPL LEU R 133 ? UNP P0ABE7 ?   ?   linker                  -5   30 
2 8ZPL VAL R 134 ? UNP P0ABE7 ?   ?   linker                  -4   31 
2 8ZPL PRO R 135 ? UNP P0ABE7 ?   ?   linker                  -3   32 
2 8ZPL ARG R 136 ? UNP P0ABE7 ?   ?   linker                  -2   33 
2 8ZPL GLY R 137 ? UNP P0ABE7 ?   ?   linker                  -1   34 
2 8ZPL SER R 138 ? UNP P0ABE7 ?   ?   linker                  0    35 
3 8ZPL TRP R 263 ? UNP P61073 LEU 125 conflict                125  36 
3 8ZPL ARG R 363 ? UNP P61073 ?   ?   linker                  225  37 
3 8ZPL LEU R 364 ? UNP P61073 ?   ?   linker                  226  38 
3 8ZPL LYS R 365 ? UNP P61073 ?   ?   linker                  227  39 
3 8ZPL SER R 366 ? UNP P61073 ?   ?   linker                  228  40 
3 8ZPL VAL R 367 ? UNP P61073 ?   ?   linker                  229  41 
3 8ZPL ARG R 368 ? UNP P61073 ?   ?   linker                  230  42 
3 8ZPL LEU R 369 ? UNP P61073 ?   ?   linker                  231  43 
3 8ZPL LEU R 370 ? UNP P61073 ?   ?   linker                  232  44 
3 8ZPL SER R 371 ? UNP P61073 ?   ?   linker                  233  45 
3 8ZPL GLY R 372 ? UNP P61073 ?   ?   linker                  234  46 
3 8ZPL SER R 373 ? UNP P61073 ?   ?   linker                  235  47 
3 8ZPL ARG R 374 ? UNP P61073 ?   ?   linker                  236  48 
3 8ZPL GLU R 375 ? UNP P61073 ?   ?   linker                  237  49 
3 8ZPL LYS R 376 ? UNP P61073 ?   ?   linker                  238  50 
3 8ZPL ASP R 377 ? UNP P61073 ?   ?   linker                  239  51 
3 8ZPL ARG R 378 ? UNP P61073 ?   ?   linker                  240  52 
3 8ZPL ASN R 379 ? UNP P61073 ?   ?   linker                  241  53 
3 8ZPL LEU R 380 ? UNP P61073 ?   ?   linker                  242  54 
3 8ZPL ARG R 381 ? UNP P61073 ?   ?   linker                  243  55 
3 8ZPL ARG R 382 ? UNP P61073 ?   ?   linker                  244  56 
3 8ZPL ILE R 383 ? UNP P61073 ?   ?   linker                  245  57 
3 8ZPL THR R 384 ? UNP P61073 ?   ?   linker                  246  58 
3 8ZPL ARG R 385 ? UNP P61073 ?   ?   linker                  247  59 
3 8ZPL PRO R 386 ? UNP P61073 ?   ?   linker                  248  60 
4 8ZPL GLY R 466 ? UNP P61073 ?   ?   'expression tag'        328  61 
4 8ZPL ARG R 467 ? UNP P61073 ?   ?   'expression tag'        329  62 
4 8ZPL PRO R 468 ? UNP P61073 ?   ?   'expression tag'        330  63 
4 8ZPL LEU R 469 ? UNP P61073 ?   ?   'expression tag'        331  64 
4 8ZPL GLU R 470 ? UNP P61073 ?   ?   'expression tag'        332  65 
4 8ZPL VAL R 471 ? UNP P61073 ?   ?   'expression tag'        333  66 
4 8ZPL LEU R 472 ? UNP P61073 ?   ?   'expression tag'        334  67 
4 8ZPL PHE R 473 ? UNP P61073 ?   ?   'expression tag'        335  68 
4 8ZPL GLN R 474 ? UNP P61073 ?   ?   'expression tag'        336  69 
4 8ZPL GLY R 475 ? UNP P61073 ?   ?   'expression tag'        337  70 
4 8ZPL PRO R 476 ? UNP P61073 ?   ?   'expression tag'        338  71 
4 8ZPL HIS R 477 ? UNP P61073 ?   ?   'expression tag'        339  72 
4 8ZPL HIS R 478 ? UNP P61073 ?   ?   'expression tag'        340  73 
4 8ZPL HIS R 479 ? UNP P61073 ?   ?   'expression tag'        341  74 
4 8ZPL HIS R 480 ? UNP P61073 ?   ?   'expression tag'        342  75 
4 8ZPL HIS R 481 ? UNP P61073 ?   ?   'expression tag'        343  76 
4 8ZPL HIS R 482 ? UNP P61073 ?   ?   'expression tag'        344  77 
4 8ZPL HIS R 483 ? UNP P61073 ?   ?   'expression tag'        345  78 
4 8ZPL HIS R 484 ? UNP P61073 ?   ?   'expression tag'        346  79 
4 8ZPL HIS R 485 ? UNP P61073 ?   ?   'expression tag'        347  80 
4 8ZPL HIS R 486 ? UNP P61073 ?   ?   'expression tag'        348  81 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 100 ? LYS A 104 ? GLY N 62  LYS N 66  5 ? 5  
HELX_P HELX_P2  AA2 LYS A 126 ? THR A 130 ? LYS N 88  THR N 92  5 ? 5  
HELX_P HELX_P3  AA3 ASN B 173 ? GLY B 202 ? ASN R 35  GLY R 64  1 ? 30 
HELX_P HELX_P4  AA4 SER B 209 ? ILE B 227 ? SER R 71  ILE R 89  1 ? 19 
HELX_P HELX_P5  AA5 THR B 228 ? ALA B 238 ? THR R 90  ALA R 100 1 ? 11 
HELX_P HELX_P6  AA6 GLY B 243 ? HIS B 278 ? GLY R 105 HIS R 140 1 ? 36 
HELX_P HELX_P7  AA7 GLN B 283 ? LYS B 292 ? GLN R 145 LYS R 154 1 ? 10 
HELX_P HELX_P8  AA8 LYS B 292 ? LEU B 305 ? LYS R 154 LEU R 167 1 ? 14 
HELX_P HELX_P9  AA9 THR B 306 ? PHE B 312 ? THR R 168 PHE R 174 1 ? 7  
HELX_P HELX_P10 AB1 ASN B 330 ? LYS B 365 ? ASN R 192 LYS R 227 1 ? 36 
HELX_P HELX_P11 AB2 SER B 373 ? LEU B 413 ? SER R 235 LEU R 275 1 ? 41 
HELX_P HELX_P12 AB3 GLY B 419 ? PHE B 438 ? GLY R 281 PHE R 300 1 ? 20 
HELX_P HELX_P13 AB4 PHE B 439 ? CYS B 441 ? PHE R 301 CYS R 303 5 ? 3  
HELX_P HELX_P14 AB5 CYS B 442 ? GLY B 452 ? CYS R 304 GLY R 314 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 62  SG ? ? ? 1_555 A CYS 135 SG ? ? N CYS 24  N CYS 97  1_555 ? ? ? ? ? ? ? 2.031 ? ? 
disulf2 disulf ? ? B CYS 247 SG ? ? ? 1_555 B CYS 324 SG ? ? R CYS 109 R CYS 186 1_555 ? ? ? ? ? ? ? 2.031 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 62  ? CYS A 135 ? CYS N 24  ? 1_555 CYS N 97  ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS B 247 ? CYS B 324 ? CYS R 109 ? 1_555 CYS R 186 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 5 ? 
AA3 ? 4 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 42  ? SER A 47  ? VAL N 4   SER N 9   
AA1 2 LEU A 58  ? GLY A 66  ? LEU N 20  GLY N 28  
AA1 3 THR A 117 ? MET A 122 ? THR N 79  MET N 84  
AA1 4 PHE A 107 ? ASP A 112 ? PHE N 69  ASP N 74  
AA2 1 GLY A 50  ? GLN A 53  ? GLY N 12  GLN N 15  
AA2 2 THR A 155 ? SER A 160 ? THR N 117 SER N 122 
AA2 3 ALA A 131 ? ARG A 140 ? ALA N 93  ARG N 102 
AA2 4 ARG A 70  ? TYR A 77  ? ARG N 32  TYR N 39  
AA2 5 LEU A 87  ? THR A 92  ? LEU N 49  THR N 54  
AA3 1 GLY A 50  ? GLN A 53  ? GLY N 12  GLN N 15  
AA3 2 THR A 155 ? SER A 160 ? THR N 117 SER N 122 
AA3 3 ALA A 131 ? ARG A 140 ? ALA N 93  ARG N 102 
AA3 4 LEU A 148 ? TRP A 151 ? LEU N 110 TRP N 113 
AA4 1 ALA B 313 ? VAL B 315 ? ALA R 175 VAL R 177 
AA4 2 CYS B 324 ? ARG B 326 ? CYS R 186 ARG R 188 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 43  ? N GLN N 5   O SER A 65  ? O SER N 27  
AA1 2 3 N LEU A 60  ? N LEU N 22  O LEU A 120 ? O LEU N 82  
AA1 3 4 O TYR A 119 ? O TYR N 81  N SER A 110 ? N SER N 72  
AA2 1 2 N VAL A 52  ? N VAL N 14  O SER A 160 ? O SER N 122 
AA2 2 3 O THR A 155 ? O THR N 117 N TYR A 133 ? N TYR N 95  
AA2 3 4 O GLU A 138 ? O GLU N 100 N TYR A 72  ? N TYR N 34  
AA2 4 5 N TRP A 76  ? N TRP N 38  O ALA A 89  ? O ALA N 51  
AA3 1 2 N VAL A 52  ? N VAL N 14  O SER A 160 ? O SER N 122 
AA3 2 3 O THR A 155 ? O THR N 117 N TYR A 133 ? N TYR N 95  
AA3 3 4 N TYR A 139 ? N TYR N 101 O LEU A 148 ? O LEU N 110 
AA4 1 2 N ASN B 314 ? N ASN R 176 O ASP B 325 ? O ASP R 187 
# 
_pdbx_entry_details.entry_id                   8ZPL 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER R 71  ? ? -66.00  -179.48 
2 1 ASN R 101 ? ? -172.10 -173.75 
3 1 PRO R 147 ? ? -85.04  39.51   
4 1 ASP R 182 ? ? 71.84   -5.87   
5 1 SER R 233 ? ? 57.06   -125.99 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8ZPL 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8ZPL 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.01 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               142111 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               'MULTIPLE SOURCES' 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 HF51116-CXCR4-KOR-Nb6 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2' 
# 
_em_imaging.entry_id                        8ZPL 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1500 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8ZPL 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8ZPL 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 N MET -37  ? A MET 1   
2   1 Y 1 N LEU -36  ? A LEU 2   
3   1 Y 1 N LEU -35  ? A LEU 3   
4   1 Y 1 N VAL -34  ? A VAL 4   
5   1 Y 1 N ASN -33  ? A ASN 5   
6   1 Y 1 N GLN -32  ? A GLN 6   
7   1 Y 1 N SER -31  ? A SER 7   
8   1 Y 1 N HIS -30  ? A HIS 8   
9   1 Y 1 N GLN -29  ? A GLN 9   
10  1 Y 1 N GLY -28  ? A GLY 10  
11  1 Y 1 N PHE -27  ? A PHE 11  
12  1 Y 1 N ASN -26  ? A ASN 12  
13  1 Y 1 N LYS -25  ? A LYS 13  
14  1 Y 1 N GLU -24  ? A GLU 14  
15  1 Y 1 N HIS -23  ? A HIS 15  
16  1 Y 1 N THR -22  ? A THR 16  
17  1 Y 1 N SER -21  ? A SER 17  
18  1 Y 1 N LYS -20  ? A LYS 18  
19  1 Y 1 N MET -19  ? A MET 19  
20  1 Y 1 N VAL -18  ? A VAL 20  
21  1 Y 1 N SER -17  ? A SER 21  
22  1 Y 1 N ALA -16  ? A ALA 22  
23  1 Y 1 N ILE -15  ? A ILE 23  
24  1 Y 1 N VAL -14  ? A VAL 24  
25  1 Y 1 N LEU -13  ? A LEU 25  
26  1 Y 1 N TYR -12  ? A TYR 26  
27  1 Y 1 N VAL -11  ? A VAL 27  
28  1 Y 1 N LEU -10  ? A LEU 28  
29  1 Y 1 N LEU -9   ? A LEU 29  
30  1 Y 1 N ALA -8   ? A ALA 30  
31  1 Y 1 N ALA -7   ? A ALA 31  
32  1 Y 1 N ALA -6   ? A ALA 32  
33  1 Y 1 N ALA -5   ? A ALA 33  
34  1 Y 1 N HIS -4   ? A HIS 34  
35  1 Y 1 N SER -3   ? A SER 35  
36  1 Y 1 N ALA -2   ? A ALA 36  
37  1 Y 1 N PHE -1   ? A PHE 37  
38  1 Y 1 N ALA 0    ? A ALA 38  
39  1 Y 1 N MET 1    ? A MET 39  
40  1 Y 1 N ALA 2    ? A ALA 40  
41  1 Y 1 N ARG 41   ? A ARG 79  
42  1 Y 1 N VAL 42   ? A VAL 80  
43  1 Y 1 N SER 43   ? A SER 81  
44  1 Y 1 N GLY 44   ? A GLY 82  
45  1 Y 1 N ASN 45   ? A ASN 83  
46  1 Y 1 N HIS 124  ? A HIS 162 
47  1 Y 1 N HIS 125  ? A HIS 163 
48  1 Y 1 N HIS 126  ? A HIS 164 
49  1 Y 1 N HIS 127  ? A HIS 165 
50  1 Y 1 N HIS 128  ? A HIS 166 
51  1 Y 1 N HIS 129  ? A HIS 167 
52  1 Y 1 N HIS 130  ? A HIS 168 
53  1 Y 1 N HIS 131  ? A HIS 169 
54  1 Y 1 R MET -137 ? B MET 1   
55  1 Y 1 R LYS -136 ? B LYS 2   
56  1 Y 1 R THR -135 ? B THR 3   
57  1 Y 1 R ILE -134 ? B ILE 4   
58  1 Y 1 R ILE -133 ? B ILE 5   
59  1 Y 1 R ALA -132 ? B ALA 6   
60  1 Y 1 R LEU -131 ? B LEU 7   
61  1 Y 1 R SER -130 ? B SER 8   
62  1 Y 1 R TYR -129 ? B TYR 9   
63  1 Y 1 R ILE -128 ? B ILE 10  
64  1 Y 1 R PHE -127 ? B PHE 11  
65  1 Y 1 R CYS -126 ? B CYS 12  
66  1 Y 1 R LEU -125 ? B LEU 13  
67  1 Y 1 R VAL -124 ? B VAL 14  
68  1 Y 1 R PHE -123 ? B PHE 15  
69  1 Y 1 R ALA -122 ? B ALA 16  
70  1 Y 1 R ASP -121 ? B ASP 17  
71  1 Y 1 R TYR -120 ? B TYR 18  
72  1 Y 1 R LYS -119 ? B LYS 19  
73  1 Y 1 R ASP -118 ? B ASP 20  
74  1 Y 1 R ASP -117 ? B ASP 21  
75  1 Y 1 R ASP -116 ? B ASP 22  
76  1 Y 1 R ASP -115 ? B ASP 23  
77  1 Y 1 R LYS -114 ? B LYS 24  
78  1 Y 1 R GLY -113 ? B GLY 25  
79  1 Y 1 R SER -112 ? B SER 26  
80  1 Y 1 R ALA -111 ? B ALA 27  
81  1 Y 1 R ASP -110 ? B ASP 28  
82  1 Y 1 R LEU -109 ? B LEU 29  
83  1 Y 1 R GLU -108 ? B GLU 30  
84  1 Y 1 R ASP -107 ? B ASP 31  
85  1 Y 1 R ASN -106 ? B ASN 32  
86  1 Y 1 R TRP -105 ? B TRP 33  
87  1 Y 1 R GLU -104 ? B GLU 34  
88  1 Y 1 R THR -103 ? B THR 35  
89  1 Y 1 R LEU -102 ? B LEU 36  
90  1 Y 1 R ASN -101 ? B ASN 37  
91  1 Y 1 R ASP -100 ? B ASP 38  
92  1 Y 1 R ASN -99  ? B ASN 39  
93  1 Y 1 R LEU -98  ? B LEU 40  
94  1 Y 1 R LYS -97  ? B LYS 41  
95  1 Y 1 R VAL -96  ? B VAL 42  
96  1 Y 1 R ILE -95  ? B ILE 43  
97  1 Y 1 R GLU -94  ? B GLU 44  
98  1 Y 1 R LYS -93  ? B LYS 45  
99  1 Y 1 R ALA -92  ? B ALA 46  
100 1 Y 1 R ASP -91  ? B ASP 47  
101 1 Y 1 R ASN -90  ? B ASN 48  
102 1 Y 1 R ALA -89  ? B ALA 49  
103 1 Y 1 R ALA -88  ? B ALA 50  
104 1 Y 1 R GLN -87  ? B GLN 51  
105 1 Y 1 R VAL -86  ? B VAL 52  
106 1 Y 1 R LYS -85  ? B LYS 53  
107 1 Y 1 R ASP -84  ? B ASP 54  
108 1 Y 1 R ALA -83  ? B ALA 55  
109 1 Y 1 R LEU -82  ? B LEU 56  
110 1 Y 1 R THR -81  ? B THR 57  
111 1 Y 1 R LYS -80  ? B LYS 58  
112 1 Y 1 R MET -79  ? B MET 59  
113 1 Y 1 R ARG -78  ? B ARG 60  
114 1 Y 1 R ALA -77  ? B ALA 61  
115 1 Y 1 R ALA -76  ? B ALA 62  
116 1 Y 1 R ALA -75  ? B ALA 63  
117 1 Y 1 R LEU -74  ? B LEU 64  
118 1 Y 1 R ASP -73  ? B ASP 65  
119 1 Y 1 R ALA -72  ? B ALA 66  
120 1 Y 1 R GLN -71  ? B GLN 67  
121 1 Y 1 R LYS -70  ? B LYS 68  
122 1 Y 1 R ALA -69  ? B ALA 69  
123 1 Y 1 R THR -68  ? B THR 70  
124 1 Y 1 R PRO -67  ? B PRO 71  
125 1 Y 1 R PRO -66  ? B PRO 72  
126 1 Y 1 R LYS -65  ? B LYS 73  
127 1 Y 1 R LEU -64  ? B LEU 74  
128 1 Y 1 R GLU -63  ? B GLU 75  
129 1 Y 1 R ASP -62  ? B ASP 76  
130 1 Y 1 R LYS -61  ? B LYS 77  
131 1 Y 1 R SER -60  ? B SER 78  
132 1 Y 1 R PRO -59  ? B PRO 79  
133 1 Y 1 R ASP -58  ? B ASP 80  
134 1 Y 1 R SER -57  ? B SER 81  
135 1 Y 1 R PRO -56  ? B PRO 82  
136 1 Y 1 R GLU -55  ? B GLU 83  
137 1 Y 1 R MET -54  ? B MET 84  
138 1 Y 1 R LYS -53  ? B LYS 85  
139 1 Y 1 R ASP -52  ? B ASP 86  
140 1 Y 1 R PHE -51  ? B PHE 87  
141 1 Y 1 R ARG -50  ? B ARG 88  
142 1 Y 1 R HIS -49  ? B HIS 89  
143 1 Y 1 R GLY -48  ? B GLY 90  
144 1 Y 1 R PHE -47  ? B PHE 91  
145 1 Y 1 R ASP -46  ? B ASP 92  
146 1 Y 1 R ILE -45  ? B ILE 93  
147 1 Y 1 R LEU -44  ? B LEU 94  
148 1 Y 1 R VAL -43  ? B VAL 95  
149 1 Y 1 R GLY -42  ? B GLY 96  
150 1 Y 1 R GLN -41  ? B GLN 97  
151 1 Y 1 R ILE -40  ? B ILE 98  
152 1 Y 1 R ASP -39  ? B ASP 99  
153 1 Y 1 R ASP -38  ? B ASP 100 
154 1 Y 1 R ALA -37  ? B ALA 101 
155 1 Y 1 R LEU -36  ? B LEU 102 
156 1 Y 1 R LYS -35  ? B LYS 103 
157 1 Y 1 R LEU -34  ? B LEU 104 
158 1 Y 1 R ALA -33  ? B ALA 105 
159 1 Y 1 R ASN -32  ? B ASN 106 
160 1 Y 1 R GLU -31  ? B GLU 107 
161 1 Y 1 R GLY -30  ? B GLY 108 
162 1 Y 1 R LYS -29  ? B LYS 109 
163 1 Y 1 R VAL -28  ? B VAL 110 
164 1 Y 1 R LYS -27  ? B LYS 111 
165 1 Y 1 R GLU -26  ? B GLU 112 
166 1 Y 1 R ALA -25  ? B ALA 113 
167 1 Y 1 R GLN -24  ? B GLN 114 
168 1 Y 1 R ALA -23  ? B ALA 115 
169 1 Y 1 R ALA -22  ? B ALA 116 
170 1 Y 1 R ALA -21  ? B ALA 117 
171 1 Y 1 R GLU -20  ? B GLU 118 
172 1 Y 1 R GLN -19  ? B GLN 119 
173 1 Y 1 R LEU -18  ? B LEU 120 
174 1 Y 1 R LYS -17  ? B LYS 121 
175 1 Y 1 R THR -16  ? B THR 122 
176 1 Y 1 R THR -15  ? B THR 123 
177 1 Y 1 R ARG -14  ? B ARG 124 
178 1 Y 1 R ASN -13  ? B ASN 125 
179 1 Y 1 R ALA -12  ? B ALA 126 
180 1 Y 1 R TYR -11  ? B TYR 127 
181 1 Y 1 R ILE -10  ? B ILE 128 
182 1 Y 1 R GLN -9   ? B GLN 129 
183 1 Y 1 R LYS -8   ? B LYS 130 
184 1 Y 1 R TYR -7   ? B TYR 131 
185 1 Y 1 R LEU -6   ? B LEU 132 
186 1 Y 1 R LEU -5   ? B LEU 133 
187 1 Y 1 R VAL -4   ? B VAL 134 
188 1 Y 1 R PRO -3   ? B PRO 135 
189 1 Y 1 R ARG -2   ? B ARG 136 
190 1 Y 1 R GLY -1   ? B GLY 137 
191 1 Y 1 R SER 0    ? B SER 138 
192 1 Y 1 R MET 1    ? B MET 139 
193 1 Y 1 R GLU 2    ? B GLU 140 
194 1 Y 1 R GLY 3    ? B GLY 141 
195 1 Y 1 R ILE 4    ? B ILE 142 
196 1 Y 1 R SER 5    ? B SER 143 
197 1 Y 1 R ILE 6    ? B ILE 144 
198 1 Y 1 R TYR 7    ? B TYR 145 
199 1 Y 1 R THR 8    ? B THR 146 
200 1 Y 1 R SER 9    ? B SER 147 
201 1 Y 1 R ASP 10   ? B ASP 148 
202 1 Y 1 R ASN 11   ? B ASN 149 
203 1 Y 1 R TYR 12   ? B TYR 150 
204 1 Y 1 R THR 13   ? B THR 151 
205 1 Y 1 R GLU 14   ? B GLU 152 
206 1 Y 1 R GLU 15   ? B GLU 153 
207 1 Y 1 R MET 16   ? B MET 154 
208 1 Y 1 R GLY 17   ? B GLY 155 
209 1 Y 1 R SER 18   ? B SER 156 
210 1 Y 1 R GLY 19   ? B GLY 157 
211 1 Y 1 R ASP 20   ? B ASP 158 
212 1 Y 1 R TYR 21   ? B TYR 159 
213 1 Y 1 R ASP 22   ? B ASP 160 
214 1 Y 1 R SER 23   ? B SER 161 
215 1 Y 1 R MET 24   ? B MET 162 
216 1 Y 1 R LYS 25   ? B LYS 163 
217 1 Y 1 R GLU 26   ? B GLU 164 
218 1 Y 1 R PRO 27   ? B PRO 165 
219 1 Y 1 R CYS 28   ? B CYS 166 
220 1 Y 1 R PHE 29   ? B PHE 167 
221 1 Y 1 R ARG 30   ? B ARG 168 
222 1 Y 1 R GLU 31   ? B GLU 169 
223 1 Y 1 R GLU 32   ? B GLU 170 
224 1 Y 1 R ASN 33   ? B ASN 171 
225 1 Y 1 R LYS 316  ? B LYS 454 
226 1 Y 1 R PHE 317  ? B PHE 455 
227 1 Y 1 R LYS 318  ? B LYS 456 
228 1 Y 1 R THR 319  ? B THR 457 
229 1 Y 1 R SER 320  ? B SER 458 
230 1 Y 1 R ALA 321  ? B ALA 459 
231 1 Y 1 R GLN 322  ? B GLN 460 
232 1 Y 1 R HIS 323  ? B HIS 461 
233 1 Y 1 R ALA 324  ? B ALA 462 
234 1 Y 1 R LEU 325  ? B LEU 463 
235 1 Y 1 R THR 326  ? B THR 464 
236 1 Y 1 R SER 327  ? B SER 465 
237 1 Y 1 R GLY 328  ? B GLY 466 
238 1 Y 1 R ARG 329  ? B ARG 467 
239 1 Y 1 R PRO 330  ? B PRO 468 
240 1 Y 1 R LEU 331  ? B LEU 469 
241 1 Y 1 R GLU 332  ? B GLU 470 
242 1 Y 1 R VAL 333  ? B VAL 471 
243 1 Y 1 R LEU 334  ? B LEU 472 
244 1 Y 1 R PHE 335  ? B PHE 473 
245 1 Y 1 R GLN 336  ? B GLN 474 
246 1 Y 1 R GLY 337  ? B GLY 475 
247 1 Y 1 R PRO 338  ? B PRO 476 
248 1 Y 1 R HIS 339  ? B HIS 477 
249 1 Y 1 R HIS 340  ? B HIS 478 
250 1 Y 1 R HIS 341  ? B HIS 479 
251 1 Y 1 R HIS 342  ? B HIS 480 
252 1 Y 1 R HIS 343  ? B HIS 481 
253 1 Y 1 R HIS 344  ? B HIS 482 
254 1 Y 1 R HIS 345  ? B HIS 483 
255 1 Y 1 R HIS 346  ? B HIS 484 
256 1 Y 1 R HIS 347  ? B HIS 485 
257 1 Y 1 R HIS 348  ? B HIS 486 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1D8K C1   C N N 1   
A1D8K C10  C N N 2   
A1D8K C11  C Y N 3   
A1D8K C12  C Y N 4   
A1D8K C13  C Y N 5   
A1D8K C14  C Y N 6   
A1D8K C15  C Y N 7   
A1D8K C16  C Y N 8   
A1D8K C17  C N N 9   
A1D8K C18  C N N 10  
A1D8K C19  C N S 11  
A1D8K C2   C N N 12  
A1D8K C20  C N N 13  
A1D8K C21  C N N 14  
A1D8K C22  C N N 15  
A1D8K C23  C N N 16  
A1D8K C24  C N N 17  
A1D8K C25  C Y N 18  
A1D8K C26  C Y N 19  
A1D8K C27  C Y N 20  
A1D8K C28  C Y N 21  
A1D8K C29  C Y N 22  
A1D8K C3   C N N 23  
A1D8K C4   C N N 24  
A1D8K C5   C N N 25  
A1D8K C6   C N N 26  
A1D8K C7   C N N 27  
A1D8K C8   C N N 28  
A1D8K C9   C N N 29  
A1D8K N1   N N N 30  
A1D8K N2   N N N 31  
A1D8K N3   N N N 32  
A1D8K N4   N N N 33  
A1D8K N5   N N N 34  
A1D8K N6   N N N 35  
A1D8K N7   N N N 36  
A1D8K N8   N Y N 37  
A1D8K O1   O N N 38  
A1D8K H1   H N N 39  
A1D8K H2   H N N 40  
A1D8K H3   H N N 41  
A1D8K H4   H N N 42  
A1D8K H5   H N N 43  
A1D8K H6   H N N 44  
A1D8K H7   H N N 45  
A1D8K H8   H N N 46  
A1D8K H9   H N N 47  
A1D8K H10  H N N 48  
A1D8K H11  H N N 49  
A1D8K H12  H N N 50  
A1D8K H13  H N N 51  
A1D8K H14  H N N 52  
A1D8K H15  H N N 53  
A1D8K H16  H N N 54  
A1D8K H17  H N N 55  
A1D8K H18  H N N 56  
A1D8K H19  H N N 57  
A1D8K H20  H N N 58  
A1D8K H21  H N N 59  
A1D8K H22  H N N 60  
A1D8K H23  H N N 61  
A1D8K H24  H N N 62  
A1D8K H25  H N N 63  
A1D8K H26  H N N 64  
A1D8K H27  H N N 65  
A1D8K H28  H N N 66  
A1D8K H29  H N N 67  
A1D8K H30  H N N 68  
A1D8K H31  H N N 69  
A1D8K H32  H N N 70  
A1D8K H33  H N N 71  
A1D8K H34  H N N 72  
A1D8K H35  H N N 73  
A1D8K H36  H N N 74  
A1D8K H37  H N N 75  
A1D8K H38  H N N 76  
A1D8K H39  H N N 77  
A1D8K H41  H N N 78  
A1D8K H43  H N N 79  
A1D8K H45  H N N 80  
A1D8K H46  H N N 81  
A1D8K H47  H N N 82  
A1D8K H48  H N N 83  
A1D8K H40  H N N 84  
ALA   N    N N N 85  
ALA   CA   C N S 86  
ALA   C    C N N 87  
ALA   O    O N N 88  
ALA   CB   C N N 89  
ALA   OXT  O N N 90  
ALA   H    H N N 91  
ALA   H2   H N N 92  
ALA   HA   H N N 93  
ALA   HB1  H N N 94  
ALA   HB2  H N N 95  
ALA   HB3  H N N 96  
ALA   HXT  H N N 97  
ARG   N    N N N 98  
ARG   CA   C N S 99  
ARG   C    C N N 100 
ARG   O    O N N 101 
ARG   CB   C N N 102 
ARG   CG   C N N 103 
ARG   CD   C N N 104 
ARG   NE   N N N 105 
ARG   CZ   C N N 106 
ARG   NH1  N N N 107 
ARG   NH2  N N N 108 
ARG   OXT  O N N 109 
ARG   H    H N N 110 
ARG   H2   H N N 111 
ARG   HA   H N N 112 
ARG   HB2  H N N 113 
ARG   HB3  H N N 114 
ARG   HG2  H N N 115 
ARG   HG3  H N N 116 
ARG   HD2  H N N 117 
ARG   HD3  H N N 118 
ARG   HE   H N N 119 
ARG   HH11 H N N 120 
ARG   HH12 H N N 121 
ARG   HH21 H N N 122 
ARG   HH22 H N N 123 
ARG   HXT  H N N 124 
ASN   N    N N N 125 
ASN   CA   C N S 126 
ASN   C    C N N 127 
ASN   O    O N N 128 
ASN   CB   C N N 129 
ASN   CG   C N N 130 
ASN   OD1  O N N 131 
ASN   ND2  N N N 132 
ASN   OXT  O N N 133 
ASN   H    H N N 134 
ASN   H2   H N N 135 
ASN   HA   H N N 136 
ASN   HB2  H N N 137 
ASN   HB3  H N N 138 
ASN   HD21 H N N 139 
ASN   HD22 H N N 140 
ASN   HXT  H N N 141 
ASP   N    N N N 142 
ASP   CA   C N S 143 
ASP   C    C N N 144 
ASP   O    O N N 145 
ASP   CB   C N N 146 
ASP   CG   C N N 147 
ASP   OD1  O N N 148 
ASP   OD2  O N N 149 
ASP   OXT  O N N 150 
ASP   H    H N N 151 
ASP   H2   H N N 152 
ASP   HA   H N N 153 
ASP   HB2  H N N 154 
ASP   HB3  H N N 155 
ASP   HD2  H N N 156 
ASP   HXT  H N N 157 
CLR   C1   C N N 158 
CLR   C2   C N N 159 
CLR   C3   C N S 160 
CLR   C4   C N N 161 
CLR   C5   C N N 162 
CLR   C6   C N N 163 
CLR   C7   C N N 164 
CLR   C8   C N S 165 
CLR   C9   C N S 166 
CLR   C10  C N R 167 
CLR   C11  C N N 168 
CLR   C12  C N N 169 
CLR   C13  C N R 170 
CLR   C14  C N S 171 
CLR   C15  C N N 172 
CLR   C16  C N N 173 
CLR   C17  C N R 174 
CLR   C18  C N N 175 
CLR   C19  C N N 176 
CLR   C20  C N R 177 
CLR   C21  C N N 178 
CLR   C22  C N N 179 
CLR   C23  C N N 180 
CLR   C24  C N N 181 
CLR   C25  C N N 182 
CLR   C26  C N N 183 
CLR   C27  C N N 184 
CLR   O1   O N N 185 
CLR   H11  H N N 186 
CLR   H12  H N N 187 
CLR   H21  H N N 188 
CLR   H22  H N N 189 
CLR   H3   H N N 190 
CLR   H41  H N N 191 
CLR   H42  H N N 192 
CLR   H6   H N N 193 
CLR   H71  H N N 194 
CLR   H72  H N N 195 
CLR   H8   H N N 196 
CLR   H9   H N N 197 
CLR   H111 H N N 198 
CLR   H112 H N N 199 
CLR   H121 H N N 200 
CLR   H122 H N N 201 
CLR   H14  H N N 202 
CLR   H151 H N N 203 
CLR   H152 H N N 204 
CLR   H161 H N N 205 
CLR   H162 H N N 206 
CLR   H17  H N N 207 
CLR   H181 H N N 208 
CLR   H182 H N N 209 
CLR   H183 H N N 210 
CLR   H191 H N N 211 
CLR   H192 H N N 212 
CLR   H193 H N N 213 
CLR   H20  H N N 214 
CLR   H211 H N N 215 
CLR   H212 H N N 216 
CLR   H213 H N N 217 
CLR   H221 H N N 218 
CLR   H222 H N N 219 
CLR   H231 H N N 220 
CLR   H232 H N N 221 
CLR   H241 H N N 222 
CLR   H242 H N N 223 
CLR   H25  H N N 224 
CLR   H261 H N N 225 
CLR   H262 H N N 226 
CLR   H263 H N N 227 
CLR   H271 H N N 228 
CLR   H272 H N N 229 
CLR   H273 H N N 230 
CLR   H1   H N N 231 
CYS   N    N N N 232 
CYS   CA   C N R 233 
CYS   C    C N N 234 
CYS   O    O N N 235 
CYS   CB   C N N 236 
CYS   SG   S N N 237 
CYS   OXT  O N N 238 
CYS   H    H N N 239 
CYS   H2   H N N 240 
CYS   HA   H N N 241 
CYS   HB2  H N N 242 
CYS   HB3  H N N 243 
CYS   HG   H N N 244 
CYS   HXT  H N N 245 
GLN   N    N N N 246 
GLN   CA   C N S 247 
GLN   C    C N N 248 
GLN   O    O N N 249 
GLN   CB   C N N 250 
GLN   CG   C N N 251 
GLN   CD   C N N 252 
GLN   OE1  O N N 253 
GLN   NE2  N N N 254 
GLN   OXT  O N N 255 
GLN   H    H N N 256 
GLN   H2   H N N 257 
GLN   HA   H N N 258 
GLN   HB2  H N N 259 
GLN   HB3  H N N 260 
GLN   HG2  H N N 261 
GLN   HG3  H N N 262 
GLN   HE21 H N N 263 
GLN   HE22 H N N 264 
GLN   HXT  H N N 265 
GLU   N    N N N 266 
GLU   CA   C N S 267 
GLU   C    C N N 268 
GLU   O    O N N 269 
GLU   CB   C N N 270 
GLU   CG   C N N 271 
GLU   CD   C N N 272 
GLU   OE1  O N N 273 
GLU   OE2  O N N 274 
GLU   OXT  O N N 275 
GLU   H    H N N 276 
GLU   H2   H N N 277 
GLU   HA   H N N 278 
GLU   HB2  H N N 279 
GLU   HB3  H N N 280 
GLU   HG2  H N N 281 
GLU   HG3  H N N 282 
GLU   HE2  H N N 283 
GLU   HXT  H N N 284 
GLY   N    N N N 285 
GLY   CA   C N N 286 
GLY   C    C N N 287 
GLY   O    O N N 288 
GLY   OXT  O N N 289 
GLY   H    H N N 290 
GLY   H2   H N N 291 
GLY   HA2  H N N 292 
GLY   HA3  H N N 293 
GLY   HXT  H N N 294 
HIS   N    N N N 295 
HIS   CA   C N S 296 
HIS   C    C N N 297 
HIS   O    O N N 298 
HIS   CB   C N N 299 
HIS   CG   C Y N 300 
HIS   ND1  N Y N 301 
HIS   CD2  C Y N 302 
HIS   CE1  C Y N 303 
HIS   NE2  N Y N 304 
HIS   OXT  O N N 305 
HIS   H    H N N 306 
HIS   H2   H N N 307 
HIS   HA   H N N 308 
HIS   HB2  H N N 309 
HIS   HB3  H N N 310 
HIS   HD1  H N N 311 
HIS   HD2  H N N 312 
HIS   HE1  H N N 313 
HIS   HE2  H N N 314 
HIS   HXT  H N N 315 
ILE   N    N N N 316 
ILE   CA   C N S 317 
ILE   C    C N N 318 
ILE   O    O N N 319 
ILE   CB   C N S 320 
ILE   CG1  C N N 321 
ILE   CG2  C N N 322 
ILE   CD1  C N N 323 
ILE   OXT  O N N 324 
ILE   H    H N N 325 
ILE   H2   H N N 326 
ILE   HA   H N N 327 
ILE   HB   H N N 328 
ILE   HG12 H N N 329 
ILE   HG13 H N N 330 
ILE   HG21 H N N 331 
ILE   HG22 H N N 332 
ILE   HG23 H N N 333 
ILE   HD11 H N N 334 
ILE   HD12 H N N 335 
ILE   HD13 H N N 336 
ILE   HXT  H N N 337 
LEU   N    N N N 338 
LEU   CA   C N S 339 
LEU   C    C N N 340 
LEU   O    O N N 341 
LEU   CB   C N N 342 
LEU   CG   C N N 343 
LEU   CD1  C N N 344 
LEU   CD2  C N N 345 
LEU   OXT  O N N 346 
LEU   H    H N N 347 
LEU   H2   H N N 348 
LEU   HA   H N N 349 
LEU   HB2  H N N 350 
LEU   HB3  H N N 351 
LEU   HG   H N N 352 
LEU   HD11 H N N 353 
LEU   HD12 H N N 354 
LEU   HD13 H N N 355 
LEU   HD21 H N N 356 
LEU   HD22 H N N 357 
LEU   HD23 H N N 358 
LEU   HXT  H N N 359 
LYS   N    N N N 360 
LYS   CA   C N S 361 
LYS   C    C N N 362 
LYS   O    O N N 363 
LYS   CB   C N N 364 
LYS   CG   C N N 365 
LYS   CD   C N N 366 
LYS   CE   C N N 367 
LYS   NZ   N N N 368 
LYS   OXT  O N N 369 
LYS   H    H N N 370 
LYS   H2   H N N 371 
LYS   HA   H N N 372 
LYS   HB2  H N N 373 
LYS   HB3  H N N 374 
LYS   HG2  H N N 375 
LYS   HG3  H N N 376 
LYS   HD2  H N N 377 
LYS   HD3  H N N 378 
LYS   HE2  H N N 379 
LYS   HE3  H N N 380 
LYS   HZ1  H N N 381 
LYS   HZ2  H N N 382 
LYS   HZ3  H N N 383 
LYS   HXT  H N N 384 
MET   N    N N N 385 
MET   CA   C N S 386 
MET   C    C N N 387 
MET   O    O N N 388 
MET   CB   C N N 389 
MET   CG   C N N 390 
MET   SD   S N N 391 
MET   CE   C N N 392 
MET   OXT  O N N 393 
MET   H    H N N 394 
MET   H2   H N N 395 
MET   HA   H N N 396 
MET   HB2  H N N 397 
MET   HB3  H N N 398 
MET   HG2  H N N 399 
MET   HG3  H N N 400 
MET   HE1  H N N 401 
MET   HE2  H N N 402 
MET   HE3  H N N 403 
MET   HXT  H N N 404 
PHE   N    N N N 405 
PHE   CA   C N S 406 
PHE   C    C N N 407 
PHE   O    O N N 408 
PHE   CB   C N N 409 
PHE   CG   C Y N 410 
PHE   CD1  C Y N 411 
PHE   CD2  C Y N 412 
PHE   CE1  C Y N 413 
PHE   CE2  C Y N 414 
PHE   CZ   C Y N 415 
PHE   OXT  O N N 416 
PHE   H    H N N 417 
PHE   H2   H N N 418 
PHE   HA   H N N 419 
PHE   HB2  H N N 420 
PHE   HB3  H N N 421 
PHE   HD1  H N N 422 
PHE   HD2  H N N 423 
PHE   HE1  H N N 424 
PHE   HE2  H N N 425 
PHE   HZ   H N N 426 
PHE   HXT  H N N 427 
PRO   N    N N N 428 
PRO   CA   C N S 429 
PRO   C    C N N 430 
PRO   O    O N N 431 
PRO   CB   C N N 432 
PRO   CG   C N N 433 
PRO   CD   C N N 434 
PRO   OXT  O N N 435 
PRO   H    H N N 436 
PRO   HA   H N N 437 
PRO   HB2  H N N 438 
PRO   HB3  H N N 439 
PRO   HG2  H N N 440 
PRO   HG3  H N N 441 
PRO   HD2  H N N 442 
PRO   HD3  H N N 443 
PRO   HXT  H N N 444 
SER   N    N N N 445 
SER   CA   C N S 446 
SER   C    C N N 447 
SER   O    O N N 448 
SER   CB   C N N 449 
SER   OG   O N N 450 
SER   OXT  O N N 451 
SER   H    H N N 452 
SER   H2   H N N 453 
SER   HA   H N N 454 
SER   HB2  H N N 455 
SER   HB3  H N N 456 
SER   HG   H N N 457 
SER   HXT  H N N 458 
THR   N    N N N 459 
THR   CA   C N S 460 
THR   C    C N N 461 
THR   O    O N N 462 
THR   CB   C N R 463 
THR   OG1  O N N 464 
THR   CG2  C N N 465 
THR   OXT  O N N 466 
THR   H    H N N 467 
THR   H2   H N N 468 
THR   HA   H N N 469 
THR   HB   H N N 470 
THR   HG1  H N N 471 
THR   HG21 H N N 472 
THR   HG22 H N N 473 
THR   HG23 H N N 474 
THR   HXT  H N N 475 
TRP   N    N N N 476 
TRP   CA   C N S 477 
TRP   C    C N N 478 
TRP   O    O N N 479 
TRP   CB   C N N 480 
TRP   CG   C Y N 481 
TRP   CD1  C Y N 482 
TRP   CD2  C Y N 483 
TRP   NE1  N Y N 484 
TRP   CE2  C Y N 485 
TRP   CE3  C Y N 486 
TRP   CZ2  C Y N 487 
TRP   CZ3  C Y N 488 
TRP   CH2  C Y N 489 
TRP   OXT  O N N 490 
TRP   H    H N N 491 
TRP   H2   H N N 492 
TRP   HA   H N N 493 
TRP   HB2  H N N 494 
TRP   HB3  H N N 495 
TRP   HD1  H N N 496 
TRP   HE1  H N N 497 
TRP   HE3  H N N 498 
TRP   HZ2  H N N 499 
TRP   HZ3  H N N 500 
TRP   HH2  H N N 501 
TRP   HXT  H N N 502 
TYR   N    N N N 503 
TYR   CA   C N S 504 
TYR   C    C N N 505 
TYR   O    O N N 506 
TYR   CB   C N N 507 
TYR   CG   C Y N 508 
TYR   CD1  C Y N 509 
TYR   CD2  C Y N 510 
TYR   CE1  C Y N 511 
TYR   CE2  C Y N 512 
TYR   CZ   C Y N 513 
TYR   OH   O N N 514 
TYR   OXT  O N N 515 
TYR   H    H N N 516 
TYR   H2   H N N 517 
TYR   HA   H N N 518 
TYR   HB2  H N N 519 
TYR   HB3  H N N 520 
TYR   HD1  H N N 521 
TYR   HD2  H N N 522 
TYR   HE1  H N N 523 
TYR   HE2  H N N 524 
TYR   HH   H N N 525 
TYR   HXT  H N N 526 
VAL   N    N N N 527 
VAL   CA   C N S 528 
VAL   C    C N N 529 
VAL   O    O N N 530 
VAL   CB   C N N 531 
VAL   CG1  C N N 532 
VAL   CG2  C N N 533 
VAL   OXT  O N N 534 
VAL   H    H N N 535 
VAL   H2   H N N 536 
VAL   HA   H N N 537 
VAL   HB   H N N 538 
VAL   HG11 H N N 539 
VAL   HG12 H N N 540 
VAL   HG13 H N N 541 
VAL   HG21 H N N 542 
VAL   HG22 H N N 543 
VAL   HG23 H N N 544 
VAL   HXT  H N N 545 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1D8K C5  C6   sing N N 1   
A1D8K C5  C4   sing N N 2   
A1D8K C6  C1   sing N N 3   
A1D8K C1  C2   sing N N 4   
A1D8K C28 C27  doub Y N 5   
A1D8K C28 C29  sing Y N 6   
A1D8K C4  N1   sing N N 7   
A1D8K C4  C3   sing N N 8   
A1D8K C27 C26  sing Y N 9   
A1D8K N1  C7   sing N N 10  
A1D8K C29 N8   doub Y N 11  
A1D8K C2  C3   sing N N 12  
A1D8K C26 C25  doub Y N 13  
A1D8K N8  C25  sing Y N 14  
A1D8K C25 C24  sing N N 15  
A1D8K C7  C8   sing N N 16  
A1D8K C8  C9   sing N N 17  
A1D8K C24 N7   sing N N 18  
A1D8K C9  N2   sing N N 19  
A1D8K N7  C19  sing N N 20  
A1D8K N2  C10  sing N N 21  
A1D8K C21 C22  sing N N 22  
A1D8K C21 C20  sing N N 23  
A1D8K C10 C11  sing N N 24  
A1D8K C19 C20  sing N N 25  
A1D8K C19 C18  sing N N 26  
A1D8K C22 N4   sing N N 27  
A1D8K C16 C11  doub Y N 28  
A1D8K C16 C15  sing Y N 29  
A1D8K N5  C23  sing N N 30  
A1D8K C11 C12  sing Y N 31  
A1D8K C15 C14  doub Y N 32  
A1D8K N4  C23  doub N N 33  
A1D8K C23 N6   sing N N 34  
A1D8K C18 O1   doub N N 35  
A1D8K C18 N3   sing N N 36  
A1D8K C12 C13  doub Y N 37  
A1D8K C14 C13  sing Y N 38  
A1D8K C14 C17  sing N N 39  
A1D8K N3  C17  sing N N 40  
A1D8K C1  H1   sing N N 41  
A1D8K C1  H2   sing N N 42  
A1D8K C10 H3   sing N N 43  
A1D8K C10 H4   sing N N 44  
A1D8K C12 H5   sing N N 45  
A1D8K C13 H6   sing N N 46  
A1D8K C15 H7   sing N N 47  
A1D8K C16 H8   sing N N 48  
A1D8K C17 H9   sing N N 49  
A1D8K C17 H10  sing N N 50  
A1D8K C19 H11  sing N N 51  
A1D8K C2  H12  sing N N 52  
A1D8K C2  H13  sing N N 53  
A1D8K C20 H14  sing N N 54  
A1D8K C20 H15  sing N N 55  
A1D8K C21 H16  sing N N 56  
A1D8K C21 H17  sing N N 57  
A1D8K C22 H18  sing N N 58  
A1D8K C22 H19  sing N N 59  
A1D8K C24 H20  sing N N 60  
A1D8K C24 H21  sing N N 61  
A1D8K C26 H22  sing N N 62  
A1D8K C27 H23  sing N N 63  
A1D8K C28 H24  sing N N 64  
A1D8K C29 H25  sing N N 65  
A1D8K C3  H26  sing N N 66  
A1D8K C3  H27  sing N N 67  
A1D8K C4  H28  sing N N 68  
A1D8K C5  H29  sing N N 69  
A1D8K C5  H30  sing N N 70  
A1D8K C6  H31  sing N N 71  
A1D8K C6  H32  sing N N 72  
A1D8K C7  H33  sing N N 73  
A1D8K C7  H34  sing N N 74  
A1D8K C8  H35  sing N N 75  
A1D8K C8  H36  sing N N 76  
A1D8K C9  H37  sing N N 77  
A1D8K C9  H38  sing N N 78  
A1D8K N1  H39  sing N N 79  
A1D8K N2  H41  sing N N 80  
A1D8K N3  H43  sing N N 81  
A1D8K N5  H45  sing N N 82  
A1D8K N6  H46  sing N N 83  
A1D8K N6  H47  sing N N 84  
A1D8K N7  H48  sing N N 85  
A1D8K N5  H40  sing N N 86  
ALA   N   CA   sing N N 87  
ALA   N   H    sing N N 88  
ALA   N   H2   sing N N 89  
ALA   CA  C    sing N N 90  
ALA   CA  CB   sing N N 91  
ALA   CA  HA   sing N N 92  
ALA   C   O    doub N N 93  
ALA   C   OXT  sing N N 94  
ALA   CB  HB1  sing N N 95  
ALA   CB  HB2  sing N N 96  
ALA   CB  HB3  sing N N 97  
ALA   OXT HXT  sing N N 98  
ARG   N   CA   sing N N 99  
ARG   N   H    sing N N 100 
ARG   N   H2   sing N N 101 
ARG   CA  C    sing N N 102 
ARG   CA  CB   sing N N 103 
ARG   CA  HA   sing N N 104 
ARG   C   O    doub N N 105 
ARG   C   OXT  sing N N 106 
ARG   CB  CG   sing N N 107 
ARG   CB  HB2  sing N N 108 
ARG   CB  HB3  sing N N 109 
ARG   CG  CD   sing N N 110 
ARG   CG  HG2  sing N N 111 
ARG   CG  HG3  sing N N 112 
ARG   CD  NE   sing N N 113 
ARG   CD  HD2  sing N N 114 
ARG   CD  HD3  sing N N 115 
ARG   NE  CZ   sing N N 116 
ARG   NE  HE   sing N N 117 
ARG   CZ  NH1  sing N N 118 
ARG   CZ  NH2  doub N N 119 
ARG   NH1 HH11 sing N N 120 
ARG   NH1 HH12 sing N N 121 
ARG   NH2 HH21 sing N N 122 
ARG   NH2 HH22 sing N N 123 
ARG   OXT HXT  sing N N 124 
ASN   N   CA   sing N N 125 
ASN   N   H    sing N N 126 
ASN   N   H2   sing N N 127 
ASN   CA  C    sing N N 128 
ASN   CA  CB   sing N N 129 
ASN   CA  HA   sing N N 130 
ASN   C   O    doub N N 131 
ASN   C   OXT  sing N N 132 
ASN   CB  CG   sing N N 133 
ASN   CB  HB2  sing N N 134 
ASN   CB  HB3  sing N N 135 
ASN   CG  OD1  doub N N 136 
ASN   CG  ND2  sing N N 137 
ASN   ND2 HD21 sing N N 138 
ASN   ND2 HD22 sing N N 139 
ASN   OXT HXT  sing N N 140 
ASP   N   CA   sing N N 141 
ASP   N   H    sing N N 142 
ASP   N   H2   sing N N 143 
ASP   CA  C    sing N N 144 
ASP   CA  CB   sing N N 145 
ASP   CA  HA   sing N N 146 
ASP   C   O    doub N N 147 
ASP   C   OXT  sing N N 148 
ASP   CB  CG   sing N N 149 
ASP   CB  HB2  sing N N 150 
ASP   CB  HB3  sing N N 151 
ASP   CG  OD1  doub N N 152 
ASP   CG  OD2  sing N N 153 
ASP   OD2 HD2  sing N N 154 
ASP   OXT HXT  sing N N 155 
CLR   C1  C2   sing N N 156 
CLR   C1  C10  sing N N 157 
CLR   C1  H11  sing N N 158 
CLR   C1  H12  sing N N 159 
CLR   C2  C3   sing N N 160 
CLR   C2  H21  sing N N 161 
CLR   C2  H22  sing N N 162 
CLR   C3  C4   sing N N 163 
CLR   C3  O1   sing N N 164 
CLR   C3  H3   sing N N 165 
CLR   C4  C5   sing N N 166 
CLR   C4  H41  sing N N 167 
CLR   C4  H42  sing N N 168 
CLR   C5  C6   doub N N 169 
CLR   C5  C10  sing N N 170 
CLR   C6  C7   sing N N 171 
CLR   C6  H6   sing N N 172 
CLR   C7  C8   sing N N 173 
CLR   C7  H71  sing N N 174 
CLR   C7  H72  sing N N 175 
CLR   C8  C9   sing N N 176 
CLR   C8  C14  sing N N 177 
CLR   C8  H8   sing N N 178 
CLR   C9  C10  sing N N 179 
CLR   C9  C11  sing N N 180 
CLR   C9  H9   sing N N 181 
CLR   C10 C19  sing N N 182 
CLR   C11 C12  sing N N 183 
CLR   C11 H111 sing N N 184 
CLR   C11 H112 sing N N 185 
CLR   C12 C13  sing N N 186 
CLR   C12 H121 sing N N 187 
CLR   C12 H122 sing N N 188 
CLR   C13 C14  sing N N 189 
CLR   C13 C17  sing N N 190 
CLR   C13 C18  sing N N 191 
CLR   C14 C15  sing N N 192 
CLR   C14 H14  sing N N 193 
CLR   C15 C16  sing N N 194 
CLR   C15 H151 sing N N 195 
CLR   C15 H152 sing N N 196 
CLR   C16 C17  sing N N 197 
CLR   C16 H161 sing N N 198 
CLR   C16 H162 sing N N 199 
CLR   C17 C20  sing N N 200 
CLR   C17 H17  sing N N 201 
CLR   C18 H181 sing N N 202 
CLR   C18 H182 sing N N 203 
CLR   C18 H183 sing N N 204 
CLR   C19 H191 sing N N 205 
CLR   C19 H192 sing N N 206 
CLR   C19 H193 sing N N 207 
CLR   C20 C21  sing N N 208 
CLR   C20 C22  sing N N 209 
CLR   C20 H20  sing N N 210 
CLR   C21 H211 sing N N 211 
CLR   C21 H212 sing N N 212 
CLR   C21 H213 sing N N 213 
CLR   C22 C23  sing N N 214 
CLR   C22 H221 sing N N 215 
CLR   C22 H222 sing N N 216 
CLR   C23 C24  sing N N 217 
CLR   C23 H231 sing N N 218 
CLR   C23 H232 sing N N 219 
CLR   C24 C25  sing N N 220 
CLR   C24 H241 sing N N 221 
CLR   C24 H242 sing N N 222 
CLR   C25 C26  sing N N 223 
CLR   C25 C27  sing N N 224 
CLR   C25 H25  sing N N 225 
CLR   C26 H261 sing N N 226 
CLR   C26 H262 sing N N 227 
CLR   C26 H263 sing N N 228 
CLR   C27 H271 sing N N 229 
CLR   C27 H272 sing N N 230 
CLR   C27 H273 sing N N 231 
CLR   O1  H1   sing N N 232 
CYS   N   CA   sing N N 233 
CYS   N   H    sing N N 234 
CYS   N   H2   sing N N 235 
CYS   CA  C    sing N N 236 
CYS   CA  CB   sing N N 237 
CYS   CA  HA   sing N N 238 
CYS   C   O    doub N N 239 
CYS   C   OXT  sing N N 240 
CYS   CB  SG   sing N N 241 
CYS   CB  HB2  sing N N 242 
CYS   CB  HB3  sing N N 243 
CYS   SG  HG   sing N N 244 
CYS   OXT HXT  sing N N 245 
GLN   N   CA   sing N N 246 
GLN   N   H    sing N N 247 
GLN   N   H2   sing N N 248 
GLN   CA  C    sing N N 249 
GLN   CA  CB   sing N N 250 
GLN   CA  HA   sing N N 251 
GLN   C   O    doub N N 252 
GLN   C   OXT  sing N N 253 
GLN   CB  CG   sing N N 254 
GLN   CB  HB2  sing N N 255 
GLN   CB  HB3  sing N N 256 
GLN   CG  CD   sing N N 257 
GLN   CG  HG2  sing N N 258 
GLN   CG  HG3  sing N N 259 
GLN   CD  OE1  doub N N 260 
GLN   CD  NE2  sing N N 261 
GLN   NE2 HE21 sing N N 262 
GLN   NE2 HE22 sing N N 263 
GLN   OXT HXT  sing N N 264 
GLU   N   CA   sing N N 265 
GLU   N   H    sing N N 266 
GLU   N   H2   sing N N 267 
GLU   CA  C    sing N N 268 
GLU   CA  CB   sing N N 269 
GLU   CA  HA   sing N N 270 
GLU   C   O    doub N N 271 
GLU   C   OXT  sing N N 272 
GLU   CB  CG   sing N N 273 
GLU   CB  HB2  sing N N 274 
GLU   CB  HB3  sing N N 275 
GLU   CG  CD   sing N N 276 
GLU   CG  HG2  sing N N 277 
GLU   CG  HG3  sing N N 278 
GLU   CD  OE1  doub N N 279 
GLU   CD  OE2  sing N N 280 
GLU   OE2 HE2  sing N N 281 
GLU   OXT HXT  sing N N 282 
GLY   N   CA   sing N N 283 
GLY   N   H    sing N N 284 
GLY   N   H2   sing N N 285 
GLY   CA  C    sing N N 286 
GLY   CA  HA2  sing N N 287 
GLY   CA  HA3  sing N N 288 
GLY   C   O    doub N N 289 
GLY   C   OXT  sing N N 290 
GLY   OXT HXT  sing N N 291 
HIS   N   CA   sing N N 292 
HIS   N   H    sing N N 293 
HIS   N   H2   sing N N 294 
HIS   CA  C    sing N N 295 
HIS   CA  CB   sing N N 296 
HIS   CA  HA   sing N N 297 
HIS   C   O    doub N N 298 
HIS   C   OXT  sing N N 299 
HIS   CB  CG   sing N N 300 
HIS   CB  HB2  sing N N 301 
HIS   CB  HB3  sing N N 302 
HIS   CG  ND1  sing Y N 303 
HIS   CG  CD2  doub Y N 304 
HIS   ND1 CE1  doub Y N 305 
HIS   ND1 HD1  sing N N 306 
HIS   CD2 NE2  sing Y N 307 
HIS   CD2 HD2  sing N N 308 
HIS   CE1 NE2  sing Y N 309 
HIS   CE1 HE1  sing N N 310 
HIS   NE2 HE2  sing N N 311 
HIS   OXT HXT  sing N N 312 
ILE   N   CA   sing N N 313 
ILE   N   H    sing N N 314 
ILE   N   H2   sing N N 315 
ILE   CA  C    sing N N 316 
ILE   CA  CB   sing N N 317 
ILE   CA  HA   sing N N 318 
ILE   C   O    doub N N 319 
ILE   C   OXT  sing N N 320 
ILE   CB  CG1  sing N N 321 
ILE   CB  CG2  sing N N 322 
ILE   CB  HB   sing N N 323 
ILE   CG1 CD1  sing N N 324 
ILE   CG1 HG12 sing N N 325 
ILE   CG1 HG13 sing N N 326 
ILE   CG2 HG21 sing N N 327 
ILE   CG2 HG22 sing N N 328 
ILE   CG2 HG23 sing N N 329 
ILE   CD1 HD11 sing N N 330 
ILE   CD1 HD12 sing N N 331 
ILE   CD1 HD13 sing N N 332 
ILE   OXT HXT  sing N N 333 
LEU   N   CA   sing N N 334 
LEU   N   H    sing N N 335 
LEU   N   H2   sing N N 336 
LEU   CA  C    sing N N 337 
LEU   CA  CB   sing N N 338 
LEU   CA  HA   sing N N 339 
LEU   C   O    doub N N 340 
LEU   C   OXT  sing N N 341 
LEU   CB  CG   sing N N 342 
LEU   CB  HB2  sing N N 343 
LEU   CB  HB3  sing N N 344 
LEU   CG  CD1  sing N N 345 
LEU   CG  CD2  sing N N 346 
LEU   CG  HG   sing N N 347 
LEU   CD1 HD11 sing N N 348 
LEU   CD1 HD12 sing N N 349 
LEU   CD1 HD13 sing N N 350 
LEU   CD2 HD21 sing N N 351 
LEU   CD2 HD22 sing N N 352 
LEU   CD2 HD23 sing N N 353 
LEU   OXT HXT  sing N N 354 
LYS   N   CA   sing N N 355 
LYS   N   H    sing N N 356 
LYS   N   H2   sing N N 357 
LYS   CA  C    sing N N 358 
LYS   CA  CB   sing N N 359 
LYS   CA  HA   sing N N 360 
LYS   C   O    doub N N 361 
LYS   C   OXT  sing N N 362 
LYS   CB  CG   sing N N 363 
LYS   CB  HB2  sing N N 364 
LYS   CB  HB3  sing N N 365 
LYS   CG  CD   sing N N 366 
LYS   CG  HG2  sing N N 367 
LYS   CG  HG3  sing N N 368 
LYS   CD  CE   sing N N 369 
LYS   CD  HD2  sing N N 370 
LYS   CD  HD3  sing N N 371 
LYS   CE  NZ   sing N N 372 
LYS   CE  HE2  sing N N 373 
LYS   CE  HE3  sing N N 374 
LYS   NZ  HZ1  sing N N 375 
LYS   NZ  HZ2  sing N N 376 
LYS   NZ  HZ3  sing N N 377 
LYS   OXT HXT  sing N N 378 
MET   N   CA   sing N N 379 
MET   N   H    sing N N 380 
MET   N   H2   sing N N 381 
MET   CA  C    sing N N 382 
MET   CA  CB   sing N N 383 
MET   CA  HA   sing N N 384 
MET   C   O    doub N N 385 
MET   C   OXT  sing N N 386 
MET   CB  CG   sing N N 387 
MET   CB  HB2  sing N N 388 
MET   CB  HB3  sing N N 389 
MET   CG  SD   sing N N 390 
MET   CG  HG2  sing N N 391 
MET   CG  HG3  sing N N 392 
MET   SD  CE   sing N N 393 
MET   CE  HE1  sing N N 394 
MET   CE  HE2  sing N N 395 
MET   CE  HE3  sing N N 396 
MET   OXT HXT  sing N N 397 
PHE   N   CA   sing N N 398 
PHE   N   H    sing N N 399 
PHE   N   H2   sing N N 400 
PHE   CA  C    sing N N 401 
PHE   CA  CB   sing N N 402 
PHE   CA  HA   sing N N 403 
PHE   C   O    doub N N 404 
PHE   C   OXT  sing N N 405 
PHE   CB  CG   sing N N 406 
PHE   CB  HB2  sing N N 407 
PHE   CB  HB3  sing N N 408 
PHE   CG  CD1  doub Y N 409 
PHE   CG  CD2  sing Y N 410 
PHE   CD1 CE1  sing Y N 411 
PHE   CD1 HD1  sing N N 412 
PHE   CD2 CE2  doub Y N 413 
PHE   CD2 HD2  sing N N 414 
PHE   CE1 CZ   doub Y N 415 
PHE   CE1 HE1  sing N N 416 
PHE   CE2 CZ   sing Y N 417 
PHE   CE2 HE2  sing N N 418 
PHE   CZ  HZ   sing N N 419 
PHE   OXT HXT  sing N N 420 
PRO   N   CA   sing N N 421 
PRO   N   CD   sing N N 422 
PRO   N   H    sing N N 423 
PRO   CA  C    sing N N 424 
PRO   CA  CB   sing N N 425 
PRO   CA  HA   sing N N 426 
PRO   C   O    doub N N 427 
PRO   C   OXT  sing N N 428 
PRO   CB  CG   sing N N 429 
PRO   CB  HB2  sing N N 430 
PRO   CB  HB3  sing N N 431 
PRO   CG  CD   sing N N 432 
PRO   CG  HG2  sing N N 433 
PRO   CG  HG3  sing N N 434 
PRO   CD  HD2  sing N N 435 
PRO   CD  HD3  sing N N 436 
PRO   OXT HXT  sing N N 437 
SER   N   CA   sing N N 438 
SER   N   H    sing N N 439 
SER   N   H2   sing N N 440 
SER   CA  C    sing N N 441 
SER   CA  CB   sing N N 442 
SER   CA  HA   sing N N 443 
SER   C   O    doub N N 444 
SER   C   OXT  sing N N 445 
SER   CB  OG   sing N N 446 
SER   CB  HB2  sing N N 447 
SER   CB  HB3  sing N N 448 
SER   OG  HG   sing N N 449 
SER   OXT HXT  sing N N 450 
THR   N   CA   sing N N 451 
THR   N   H    sing N N 452 
THR   N   H2   sing N N 453 
THR   CA  C    sing N N 454 
THR   CA  CB   sing N N 455 
THR   CA  HA   sing N N 456 
THR   C   O    doub N N 457 
THR   C   OXT  sing N N 458 
THR   CB  OG1  sing N N 459 
THR   CB  CG2  sing N N 460 
THR   CB  HB   sing N N 461 
THR   OG1 HG1  sing N N 462 
THR   CG2 HG21 sing N N 463 
THR   CG2 HG22 sing N N 464 
THR   CG2 HG23 sing N N 465 
THR   OXT HXT  sing N N 466 
TRP   N   CA   sing N N 467 
TRP   N   H    sing N N 468 
TRP   N   H2   sing N N 469 
TRP   CA  C    sing N N 470 
TRP   CA  CB   sing N N 471 
TRP   CA  HA   sing N N 472 
TRP   C   O    doub N N 473 
TRP   C   OXT  sing N N 474 
TRP   CB  CG   sing N N 475 
TRP   CB  HB2  sing N N 476 
TRP   CB  HB3  sing N N 477 
TRP   CG  CD1  doub Y N 478 
TRP   CG  CD2  sing Y N 479 
TRP   CD1 NE1  sing Y N 480 
TRP   CD1 HD1  sing N N 481 
TRP   CD2 CE2  doub Y N 482 
TRP   CD2 CE3  sing Y N 483 
TRP   NE1 CE2  sing Y N 484 
TRP   NE1 HE1  sing N N 485 
TRP   CE2 CZ2  sing Y N 486 
TRP   CE3 CZ3  doub Y N 487 
TRP   CE3 HE3  sing N N 488 
TRP   CZ2 CH2  doub Y N 489 
TRP   CZ2 HZ2  sing N N 490 
TRP   CZ3 CH2  sing Y N 491 
TRP   CZ3 HZ3  sing N N 492 
TRP   CH2 HH2  sing N N 493 
TRP   OXT HXT  sing N N 494 
TYR   N   CA   sing N N 495 
TYR   N   H    sing N N 496 
TYR   N   H2   sing N N 497 
TYR   CA  C    sing N N 498 
TYR   CA  CB   sing N N 499 
TYR   CA  HA   sing N N 500 
TYR   C   O    doub N N 501 
TYR   C   OXT  sing N N 502 
TYR   CB  CG   sing N N 503 
TYR   CB  HB2  sing N N 504 
TYR   CB  HB3  sing N N 505 
TYR   CG  CD1  doub Y N 506 
TYR   CG  CD2  sing Y N 507 
TYR   CD1 CE1  sing Y N 508 
TYR   CD1 HD1  sing N N 509 
TYR   CD2 CE2  doub Y N 510 
TYR   CD2 HD2  sing N N 511 
TYR   CE1 CZ   doub Y N 512 
TYR   CE1 HE1  sing N N 513 
TYR   CE2 CZ   sing Y N 514 
TYR   CE2 HE2  sing N N 515 
TYR   CZ  OH   sing N N 516 
TYR   OH  HH   sing N N 517 
TYR   OXT HXT  sing N N 518 
VAL   N   CA   sing N N 519 
VAL   N   H    sing N N 520 
VAL   N   H2   sing N N 521 
VAL   CA  C    sing N N 522 
VAL   CA  CB   sing N N 523 
VAL   CA  HA   sing N N 524 
VAL   C   O    doub N N 525 
VAL   C   OXT  sing N N 526 
VAL   CB  CG1  sing N N 527 
VAL   CB  CG2  sing N N 528 
VAL   CB  HB   sing N N 529 
VAL   CG1 HG11 sing N N 530 
VAL   CG1 HG12 sing N N 531 
VAL   CG1 HG13 sing N N 532 
VAL   CG2 HG21 sing N N 533 
VAL   CG2 HG22 sing N N 534 
VAL   CG2 HG23 sing N N 535 
VAL   OXT HXT  sing N N 536 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-05-30 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8ZPL 
_em_admin.last_update        2025-04-02 
_em_admin.map_release_date   2025-02-26 
_em_admin.title              'Cryo-EM strucutre of CXCR4 complexed with antagonist HF51116' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         51.6 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
_em_imaging_optics.chr_aberration_corrector   ? 
_em_imaging_optics.energyfilter_lower         ? 
_em_imaging_optics.energyfilter_slit_width    20 
_em_imaging_optics.energyfilter_name          'GIF Bioquantum' 
_em_imaging_optics.energyfilter_upper         ? 
_em_imaging_optics.id                         1 
_em_imaging_optics.imaging_id                 1 
_em_imaging_optics.phase_plate                ? 
_em_imaging_optics.sph_aberration_corrector   ? 
_em_imaging_optics.details                    ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Other government' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           32100963 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8ZPL 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN   A 1 41  ? 141.748 152.131 164.888 1.00 95.97  ? 3   GLN   N N   1 
ATOM   2    C CA  . GLN   A 1 41  ? 142.330 151.983 166.216 1.00 99.07  ? 3   GLN   N CA  1 
ATOM   3    C C   . GLN   A 1 41  ? 141.249 151.736 167.261 1.00 101.24 ? 3   GLN   N C   1 
ATOM   4    O O   . GLN   A 1 41  ? 140.116 152.190 167.112 1.00 101.44 ? 3   GLN   N O   1 
ATOM   5    C CB  . GLN   A 1 41  ? 143.144 153.223 166.586 1.00 97.92  ? 3   GLN   N CB  1 
ATOM   6    N N   . VAL   A 1 42  ? 141.606 151.015 168.322 1.00 102.95 ? 4   VAL   N N   1 
ATOM   7    C CA  . VAL   A 1 42  ? 140.681 150.700 169.399 1.00 101.76 ? 4   VAL   N CA  1 
ATOM   8    C C   . VAL   A 1 42  ? 141.183 151.358 170.676 1.00 102.95 ? 4   VAL   N C   1 
ATOM   9    O O   . VAL   A 1 42  ? 142.348 151.748 170.788 1.00 105.11 ? 4   VAL   N O   1 
ATOM   10   C CB  . VAL   A 1 42  ? 140.516 149.182 169.605 1.00 99.92  ? 4   VAL   N CB  1 
ATOM   11   C CG1 . VAL   A 1 42  ? 140.039 148.523 168.325 1.00 99.85  ? 4   VAL   N CG1 1 
ATOM   12   C CG2 . VAL   A 1 42  ? 141.818 148.570 170.082 1.00 98.96  ? 4   VAL   N CG2 1 
ATOM   13   N N   . GLN   A 1 43  ? 140.285 151.476 171.647 1.00 102.75 ? 5   GLN   N N   1 
ATOM   14   C CA  . GLN   A 1 43  ? 140.596 152.080 172.933 1.00 103.80 ? 5   GLN   N CA  1 
ATOM   15   C C   . GLN   A 1 43  ? 140.295 151.091 174.050 1.00 103.48 ? 5   GLN   N C   1 
ATOM   16   O O   . GLN   A 1 43  ? 139.258 150.423 174.036 1.00 105.23 ? 5   GLN   N O   1 
ATOM   17   C CB  . GLN   A 1 43  ? 139.799 153.371 173.146 1.00 103.43 ? 5   GLN   N CB  1 
ATOM   18   N N   . LEU   A 1 44  ? 141.209 151.002 175.012 1.00 108.88 ? 6   LEU   N N   1 
ATOM   19   C CA  . LEU   A 1 44  ? 141.057 150.138 176.174 1.00 110.93 ? 6   LEU   N CA  1 
ATOM   20   C C   . LEU   A 1 44  ? 141.077 150.991 177.433 1.00 110.57 ? 6   LEU   N C   1 
ATOM   21   O O   . LEU   A 1 44  ? 141.964 151.834 177.602 1.00 112.58 ? 6   LEU   N O   1 
ATOM   22   C CB  . LEU   A 1 44  ? 142.168 149.086 176.230 1.00 111.32 ? 6   LEU   N CB  1 
ATOM   23   C CG  . LEU   A 1 44  ? 141.855 147.701 175.661 1.00 108.86 ? 6   LEU   N CG  1 
ATOM   24   C CD1 . LEU   A 1 44  ? 141.567 147.779 174.173 1.00 109.44 ? 6   LEU   N CD1 1 
ATOM   25   C CD2 . LEU   A 1 44  ? 143.002 146.745 175.935 1.00 109.01 ? 6   LEU   N CD2 1 
ATOM   26   N N   . GLN   A 1 45  ? 140.102 150.774 178.311 1.00 120.36 ? 7   GLN   N N   1 
ATOM   27   C CA  . GLN   A 1 45  ? 139.993 151.506 179.566 1.00 121.78 ? 7   GLN   N CA  1 
ATOM   28   C C   . GLN   A 1 45  ? 140.121 150.533 180.728 1.00 123.03 ? 7   GLN   N C   1 
ATOM   29   O O   . GLN   A 1 45  ? 139.474 149.482 180.736 1.00 123.94 ? 7   GLN   N O   1 
ATOM   30   C CB  . GLN   A 1 45  ? 138.667 152.265 179.650 1.00 124.08 ? 7   GLN   N CB  1 
ATOM   31   C CG  . GLN   A 1 45  ? 138.271 152.967 178.361 1.00 124.06 ? 7   GLN   N CG  1 
ATOM   32   C CD  . GLN   A 1 45  ? 136.815 153.387 178.349 1.00 125.24 ? 7   GLN   N CD  1 
ATOM   33   O OE1 . GLN   A 1 45  ? 135.993 152.846 179.089 1.00 125.21 ? 7   GLN   N OE1 1 
ATOM   34   N NE2 . GLN   A 1 45  ? 136.486 154.357 177.504 1.00 124.29 ? 7   GLN   N NE2 1 
ATOM   35   N N   . GLU   A 1 46  ? 140.948 150.889 181.705 1.00 133.58 ? 8   GLU   N N   1 
ATOM   36   C CA  . GLU   A 1 46  ? 141.207 150.051 182.865 1.00 134.18 ? 8   GLU   N CA  1 
ATOM   37   C C   . GLU   A 1 46  ? 140.651 150.709 184.120 1.00 134.79 ? 8   GLU   N C   1 
ATOM   38   O O   . GLU   A 1 46  ? 140.686 151.936 184.258 1.00 135.65 ? 8   GLU   N O   1 
ATOM   39   C CB  . GLU   A 1 46  ? 142.707 149.800 183.036 1.00 134.26 ? 8   GLU   N CB  1 
ATOM   40   C CG  . GLU   A 1 46  ? 143.290 148.798 182.058 1.00 134.54 ? 8   GLU   N CG  1 
ATOM   41   C CD  . GLU   A 1 46  ? 144.781 148.979 181.873 1.00 133.94 ? 8   GLU   N CD  1 
ATOM   42   O OE1 . GLU   A 1 46  ? 145.229 150.139 181.774 1.00 133.76 ? 8   GLU   N OE1 1 
ATOM   43   O OE2 . GLU   A 1 46  ? 145.506 147.963 181.830 1.00 134.81 ? 8   GLU   N OE2 1 
ATOM   44   N N   . SER   A 1 47  ? 140.141 149.887 185.034 1.00 140.90 ? 9   SER   N N   1 
ATOM   45   C CA  . SER   A 1 47  ? 139.619 150.377 186.300 1.00 140.60 ? 9   SER   N CA  1 
ATOM   46   C C   . SER   A 1 47  ? 139.713 149.267 187.335 1.00 141.18 ? 9   SER   N C   1 
ATOM   47   O O   . SER   A 1 47  ? 139.725 148.081 186.994 1.00 141.65 ? 9   SER   N O   1 
ATOM   48   C CB  . SER   A 1 47  ? 138.170 150.857 186.166 1.00 141.27 ? 9   SER   N CB  1 
ATOM   49   O OG  . SER   A 1 47  ? 137.272 149.762 186.142 1.00 142.14 ? 9   SER   N OG  1 
ATOM   50   N N   . GLY   A 1 48  ? 139.776 149.664 188.603 1.00 149.71 ? 10  GLY   N N   1 
ATOM   51   C CA  . GLY   A 1 48  ? 139.849 148.704 189.686 1.00 150.12 ? 10  GLY   N CA  1 
ATOM   52   C C   . GLY   A 1 48  ? 140.957 148.990 190.679 1.00 150.98 ? 10  GLY   N C   1 
ATOM   53   O O   . GLY   A 1 48  ? 141.121 148.260 191.660 1.00 150.97 ? 10  GLY   N O   1 
ATOM   54   N N   . GLY   A 1 49  ? 141.723 150.051 190.436 1.00 160.37 ? 11  GLY   N N   1 
ATOM   55   C CA  . GLY   A 1 49  ? 142.808 150.418 191.318 1.00 160.67 ? 11  GLY   N CA  1 
ATOM   56   C C   . GLY   A 1 49  ? 142.335 151.177 192.542 1.00 160.79 ? 11  GLY   N C   1 
ATOM   57   O O   . GLY   A 1 49  ? 141.158 151.496 192.708 1.00 160.33 ? 11  GLY   N O   1 
ATOM   58   N N   . GLY   A 1 50  ? 143.287 151.469 193.418 1.00 170.21 ? 12  GLY   N N   1 
ATOM   59   C CA  . GLY   A 1 50  ? 143.027 152.196 194.637 1.00 170.00 ? 12  GLY   N CA  1 
ATOM   60   C C   . GLY   A 1 50  ? 143.775 151.572 195.794 1.00 171.19 ? 12  GLY   N C   1 
ATOM   61   O O   . GLY   A 1 50  ? 144.763 150.865 195.605 1.00 171.12 ? 12  GLY   N O   1 
ATOM   62   N N   . LEU   A 1 51  ? 143.288 151.842 197.002 1.00 177.57 ? 13  LEU   N N   1 
ATOM   63   C CA  . LEU   A 1 51  ? 143.884 151.323 198.226 1.00 177.28 ? 13  LEU   N CA  1 
ATOM   64   C C   . LEU   A 1 51  ? 143.085 150.111 198.690 1.00 177.51 ? 13  LEU   N C   1 
ATOM   65   O O   . LEU   A 1 51  ? 141.870 150.206 198.898 1.00 177.98 ? 13  LEU   N O   1 
ATOM   66   C CB  . LEU   A 1 51  ? 143.919 152.396 199.314 1.00 176.48 ? 13  LEU   N CB  1 
ATOM   67   N N   . VAL   A 1 52  ? 143.767 148.979 198.851 1.00 181.34 ? 14  VAL   N N   1 
ATOM   68   C CA  . VAL   A 1 52  ? 143.133 147.731 199.250 1.00 181.98 ? 14  VAL   N CA  1 
ATOM   69   C C   . VAL   A 1 52  ? 143.969 147.083 200.345 1.00 182.42 ? 14  VAL   N C   1 
ATOM   70   O O   . VAL   A 1 52  ? 145.174 147.329 200.463 1.00 182.24 ? 14  VAL   N O   1 
ATOM   71   C CB  . VAL   A 1 52  ? 142.954 146.777 198.045 1.00 181.82 ? 14  VAL   N CB  1 
ATOM   72   C CG1 . VAL   A 1 52  ? 144.286 146.159 197.645 1.00 181.46 ? 14  VAL   N CG1 1 
ATOM   73   C CG2 . VAL   A 1 52  ? 141.913 145.704 198.346 1.00 180.87 ? 14  VAL   N CG2 1 
ATOM   74   N N   . GLN   A 1 53  ? 143.317 146.258 201.159 1.00 179.80 ? 15  GLN   N N   1 
ATOM   75   C CA  . GLN   A 1 53  ? 143.980 145.555 202.245 1.00 178.73 ? 15  GLN   N CA  1 
ATOM   76   C C   . GLN   A 1 53  ? 144.437 144.172 201.791 1.00 179.28 ? 15  GLN   N C   1 
ATOM   77   O O   . GLN   A 1 53  ? 143.930 143.610 200.817 1.00 178.75 ? 15  GLN   N O   1 
ATOM   78   C CB  . GLN   A 1 53  ? 143.050 145.429 203.452 1.00 177.42 ? 15  GLN   N CB  1 
ATOM   79   N N   . ALA   A 1 54  ? 145.412 143.629 202.515 1.00 180.25 ? 16  ALA   N N   1 
ATOM   80   C CA  . ALA   A 1 54  ? 145.944 142.314 202.188 1.00 179.67 ? 16  ALA   N CA  1 
ATOM   81   C C   . ALA   A 1 54  ? 144.906 141.231 202.456 1.00 179.50 ? 16  ALA   N C   1 
ATOM   82   O O   . ALA   A 1 54  ? 144.204 141.256 203.471 1.00 179.63 ? 16  ALA   N O   1 
ATOM   83   C CB  . ALA   A 1 54  ? 147.211 142.037 202.995 1.00 178.29 ? 16  ALA   N CB  1 
ATOM   84   N N   . GLY   A 1 55  ? 144.812 140.275 201.535 1.00 176.76 ? 17  GLY   N N   1 
ATOM   85   C CA  . GLY   A 1 55  ? 143.865 139.188 201.666 1.00 175.73 ? 17  GLY   N CA  1 
ATOM   86   C C   . GLY   A 1 55  ? 142.435 139.534 201.322 1.00 175.61 ? 17  GLY   N C   1 
ATOM   87   O O   . GLY   A 1 55  ? 141.546 138.704 201.544 1.00 175.14 ? 17  GLY   N O   1 
ATOM   88   N N   . GLU   A 1 56  ? 142.182 140.726 200.791 1.00 177.25 ? 18  GLU   N N   1 
ATOM   89   C CA  . GLU   A 1 56  ? 140.832 141.148 200.449 1.00 177.35 ? 18  GLU   N CA  1 
ATOM   90   C C   . GLU   A 1 56  ? 140.541 140.814 198.986 1.00 176.37 ? 18  GLU   N C   1 
ATOM   91   O O   . GLU   A 1 56  ? 141.297 140.098 198.324 1.00 175.52 ? 18  GLU   N O   1 
ATOM   92   C CB  . GLU   A 1 56  ? 140.654 142.634 200.748 1.00 177.61 ? 18  GLU   N CB  1 
ATOM   93   C CG  . GLU   A 1 56  ? 140.224 142.922 202.177 1.00 176.44 ? 18  GLU   N CG  1 
ATOM   94   C CD  . GLU   A 1 56  ? 138.802 142.477 202.459 1.00 176.25 ? 18  GLU   N CD  1 
ATOM   95   O OE1 . GLU   A 1 56  ? 137.994 142.425 201.508 1.00 177.31 ? 18  GLU   N OE1 1 
ATOM   96   O OE2 . GLU   A 1 56  ? 138.494 142.176 203.631 1.00 175.58 ? 18  GLU   N OE2 1 
ATOM   97   N N   . SER   A 1 57  ? 139.433 141.336 198.464 1.00 169.83 ? 19  SER   N N   1 
ATOM   98   C CA  . SER   A 1 57  ? 138.980 141.027 197.117 1.00 169.89 ? 19  SER   N CA  1 
ATOM   99   C C   . SER   A 1 57  ? 138.918 142.290 196.268 1.00 169.46 ? 19  SER   N C   1 
ATOM   100  O O   . SER   A 1 57  ? 138.626 143.382 196.764 1.00 169.13 ? 19  SER   N O   1 
ATOM   101  C CB  . SER   A 1 57  ? 137.604 140.350 197.137 1.00 169.76 ? 19  SER   N CB  1 
ATOM   102  O OG  . SER   A 1 57  ? 137.667 139.092 197.785 1.00 169.54 ? 19  SER   N OG  1 
ATOM   103  N N   . LEU   A 1 58  ? 139.201 142.125 194.977 1.00 162.80 ? 20  LEU   N N   1 
ATOM   104  C CA  . LEU   A 1 58  ? 139.123 143.205 194.006 1.00 162.75 ? 20  LEU   N CA  1 
ATOM   105  C C   . LEU   A 1 58  ? 138.579 142.651 192.697 1.00 161.71 ? 20  LEU   N C   1 
ATOM   106  O O   . LEU   A 1 58  ? 138.369 141.444 192.548 1.00 161.00 ? 20  LEU   N O   1 
ATOM   107  C CB  . LEU   A 1 58  ? 140.489 143.867 193.785 1.00 162.05 ? 20  LEU   N CB  1 
ATOM   108  C CG  . LEU   A 1 58  ? 140.833 145.031 194.716 1.00 161.96 ? 20  LEU   N CG  1 
ATOM   109  C CD1 . LEU   A 1 58  ? 142.218 145.576 194.403 1.00 161.93 ? 20  LEU   N CD1 1 
ATOM   110  C CD2 . LEU   A 1 58  ? 139.784 146.126 194.613 1.00 161.29 ? 20  LEU   N CD2 1 
ATOM   111  N N   . ARG   A 1 59  ? 138.347 143.549 191.738 1.00 146.64 ? 21  ARG   N N   1 
ATOM   112  C CA  . ARG   A 1 59  ? 137.838 143.145 190.428 1.00 146.48 ? 21  ARG   N CA  1 
ATOM   113  C C   . ARG   A 1 59  ? 138.268 144.199 189.412 1.00 146.91 ? 21  ARG   N C   1 
ATOM   114  O O   . ARG   A 1 59  ? 137.670 145.277 189.340 1.00 145.93 ? 21  ARG   N O   1 
ATOM   115  C CB  . ARG   A 1 59  ? 136.325 142.976 190.454 1.00 145.91 ? 21  ARG   N CB  1 
ATOM   116  C CG  . ARG   A 1 59  ? 135.801 141.981 189.433 1.00 146.32 ? 21  ARG   N CG  1 
ATOM   117  C CD  . ARG   A 1 59  ? 134.293 142.082 189.278 1.00 146.54 ? 21  ARG   N CD  1 
ATOM   118  N NE  . ARG   A 1 59  ? 133.712 140.826 188.818 1.00 146.59 ? 21  ARG   N NE  1 
ATOM   119  C CZ  . ARG   A 1 59  ? 132.509 140.712 188.272 1.00 146.76 ? 21  ARG   N CZ  1 
ATOM   120  N NH1 . ARG   A 1 59  ? 131.727 141.765 188.096 1.00 145.65 ? 21  ARG   N NH1 1 
ATOM   121  N NH2 . ARG   A 1 59  ? 132.080 139.512 187.892 1.00 147.29 ? 21  ARG   N NH2 1 
ATOM   122  N N   . LEU   A 1 60  ? 139.298 143.880 188.632 1.00 141.24 ? 22  LEU   N N   1 
ATOM   123  C CA  . LEU   A 1 60  ? 139.764 144.775 187.582 1.00 139.80 ? 22  LEU   N CA  1 
ATOM   124  C C   . LEU   A 1 60  ? 138.912 144.596 186.333 1.00 137.75 ? 22  LEU   N C   1 
ATOM   125  O O   . LEU   A 1 60  ? 138.624 143.467 185.923 1.00 137.88 ? 22  LEU   N O   1 
ATOM   126  C CB  . LEU   A 1 60  ? 141.233 144.506 187.261 1.00 139.87 ? 22  LEU   N CB  1 
ATOM   127  C CG  . LEU   A 1 60  ? 142.218 144.500 188.431 1.00 140.08 ? 22  LEU   N CG  1 
ATOM   128  C CD1 . LEU   A 1 60  ? 143.612 144.132 187.952 1.00 138.79 ? 22  LEU   N CD1 1 
ATOM   129  C CD2 . LEU   A 1 60  ? 142.229 145.850 189.129 1.00 140.65 ? 22  LEU   N CD2 1 
ATOM   130  N N   . SER   A 1 61  ? 138.507 145.709 185.730 1.00 133.83 ? 23  SER   N N   1 
ATOM   131  C CA  . SER   A 1 61  ? 137.714 145.700 184.510 1.00 135.52 ? 23  SER   N CA  1 
ATOM   132  C C   . SER   A 1 61  ? 138.507 146.368 183.398 1.00 134.78 ? 23  SER   N C   1 
ATOM   133  O O   . SER   A 1 61  ? 139.045 147.464 183.585 1.00 136.28 ? 23  SER   N O   1 
ATOM   134  C CB  . SER   A 1 61  ? 136.376 146.416 184.710 1.00 136.76 ? 23  SER   N CB  1 
ATOM   135  O OG  . SER   A 1 61  ? 136.568 147.802 184.937 1.00 137.34 ? 23  SER   N OG  1 
ATOM   136  N N   . CYS   A 1 62  ? 138.577 145.707 182.245 1.00 123.30 ? 24  CYS   N N   1 
ATOM   137  C CA  . CYS   A 1 62  ? 139.297 146.219 181.081 1.00 124.52 ? 24  CYS   N CA  1 
ATOM   138  C C   . CYS   A 1 62  ? 138.348 146.157 179.889 1.00 124.03 ? 24  CYS   N C   1 
ATOM   139  O O   . CYS   A 1 62  ? 138.147 145.090 179.303 1.00 125.96 ? 24  CYS   N O   1 
ATOM   140  C CB  . CYS   A 1 62  ? 140.572 145.423 180.828 1.00 127.16 ? 24  CYS   N CB  1 
ATOM   141  S SG  . CYS   A 1 62  ? 141.369 145.750 179.243 1.00 131.51 ? 24  CYS   N SG  1 
ATOM   142  N N   . ALA   A 1 63  ? 137.766 147.298 179.537 1.00 112.31 ? 25  ALA   N N   1 
ATOM   143  C CA  . ALA   A 1 63  ? 136.804 147.386 178.450 1.00 111.30 ? 25  ALA   N CA  1 
ATOM   144  C C   . ALA   A 1 63  ? 137.483 147.893 177.187 1.00 111.82 ? 25  ALA   N C   1 
ATOM   145  O O   . ALA   A 1 63  ? 138.310 148.808 177.237 1.00 114.20 ? 25  ALA   N O   1 
ATOM   146  C CB  . ALA   A 1 63  ? 135.644 148.310 178.822 1.00 113.28 ? 25  ALA   N CB  1 
ATOM   147  N N   . ALA   A 1 64  ? 137.129 147.292 176.055 1.00 102.77 ? 26  ALA   N N   1 
ATOM   148  C CA  . ALA   A 1 64  ? 137.666 147.670 174.756 1.00 102.02 ? 26  ALA   N CA  1 
ATOM   149  C C   . ALA   A 1 64  ? 136.596 148.407 173.966 1.00 102.06 ? 26  ALA   N C   1 
ATOM   150  O O   . ALA   A 1 64  ? 135.466 147.923 173.843 1.00 104.85 ? 26  ALA   N O   1 
ATOM   151  C CB  . ALA   A 1 64  ? 138.146 146.442 173.982 1.00 104.25 ? 26  ALA   N CB  1 
ATOM   152  N N   . SER   A 1 65  ? 136.951 149.574 173.434 1.00 101.24 ? 27  SER   N N   1 
ATOM   153  C CA  . SER   A 1 65  ? 136.018 150.394 172.679 1.00 101.74 ? 27  SER   N CA  1 
ATOM   154  C C   . SER   A 1 65  ? 136.691 150.896 171.411 1.00 102.64 ? 27  SER   N C   1 
ATOM   155  O O   . SER   A 1 65  ? 137.902 151.126 171.380 1.00 101.37 ? 27  SER   N O   1 
ATOM   156  C CB  . SER   A 1 65  ? 135.511 151.581 173.509 1.00 99.94  ? 27  SER   N CB  1 
ATOM   157  N N   . GLY   A 1 66  ? 135.889 151.063 170.362 1.00 99.92  ? 28  GLY   N N   1 
ATOM   158  C CA  . GLY   A 1 66  ? 136.393 151.586 169.108 1.00 99.33  ? 28  GLY   N CA  1 
ATOM   159  C C   . GLY   A 1 66  ? 135.992 150.763 167.903 1.00 99.04  ? 28  GLY   N C   1 
ATOM   160  O O   . GLY   A 1 66  ? 134.921 150.149 167.886 1.00 98.59  ? 28  GLY   N O   1 
ATOM   161  N N   . THR   A 1 67  ? 136.847 150.749 166.884 1.00 99.51  ? 29  THR   N N   1 
ATOM   162  C CA  . THR   A 1 67  ? 136.602 149.986 165.661 1.00 101.51 ? 29  THR   N CA  1 
ATOM   163  C C   . THR   A 1 67  ? 137.046 148.549 165.898 1.00 101.60 ? 29  THR   N C   1 
ATOM   164  O O   . THR   A 1 67  ? 138.201 148.185 165.673 1.00 100.79 ? 29  THR   N O   1 
ATOM   165  C CB  . THR   A 1 67  ? 137.338 150.610 164.483 1.00 102.25 ? 29  THR   N CB  1 
ATOM   166  O OG1 . THR   A 1 67  ? 138.750 150.538 164.711 1.00 102.71 ? 29  THR   N OG1 1 
ATOM   167  C CG2 . THR   A 1 67  ? 136.933 152.066 164.319 1.00 101.16 ? 29  THR   N CG2 1 
ATOM   168  N N   . ILE   A 1 68  ? 136.113 147.719 166.358 1.00 94.49  ? 30  ILE   N N   1 
ATOM   169  C CA  . ILE   A 1 68  ? 136.385 146.328 166.698 1.00 90.35  ? 30  ILE   N CA  1 
ATOM   170  C C   . ILE   A 1 68  ? 135.567 145.433 165.782 1.00 88.22  ? 30  ILE   N C   1 
ATOM   171  O O   . ILE   A 1 68  ? 134.346 145.597 165.672 1.00 90.32  ? 30  ILE   N O   1 
ATOM   172  C CB  . ILE   A 1 68  ? 136.063 146.024 168.172 1.00 90.81  ? 30  ILE   N CB  1 
ATOM   173  C CG1 . ILE   A 1 68  ? 136.995 146.803 169.100 1.00 90.06  ? 30  ILE   N CG1 1 
ATOM   174  C CG2 . ILE   A 1 68  ? 136.162 144.534 168.443 1.00 89.28  ? 30  ILE   N CG2 1 
ATOM   175  C CD1 . ILE   A 1 68  ? 136.594 146.740 170.556 1.00 90.22  ? 30  ILE   N CD1 1 
ATOM   176  N N   . PHE   A 1 69  ? 136.240 144.491 165.127 1.00 74.73  ? 31  PHE   N N   1 
ATOM   177  C CA  . PHE   A 1 69  ? 135.571 143.438 164.377 1.00 71.12  ? 31  PHE   N CA  1 
ATOM   178  C C   . PHE   A 1 69  ? 135.560 142.110 165.118 1.00 78.36  ? 31  PHE   N C   1 
ATOM   179  O O   . PHE   A 1 69  ? 134.588 141.358 165.002 1.00 82.54  ? 31  PHE   N O   1 
ATOM   180  C CB  . PHE   A 1 69  ? 136.236 143.260 163.007 1.00 69.64  ? 31  PHE   N CB  1 
ATOM   181  C CG  . PHE   A 1 69  ? 136.020 141.908 162.393 1.00 73.31  ? 31  PHE   N CG  1 
ATOM   182  C CD1 . PHE   A 1 69  ? 134.781 141.549 161.892 1.00 76.75  ? 31  PHE   N CD1 1 
ATOM   183  C CD2 . PHE   A 1 69  ? 137.059 140.998 162.308 1.00 76.68  ? 31  PHE   N CD2 1 
ATOM   184  C CE1 . PHE   A 1 69  ? 134.582 140.306 161.326 1.00 79.14  ? 31  PHE   N CE1 1 
ATOM   185  C CE2 . PHE   A 1 69  ? 136.865 139.756 161.742 1.00 75.90  ? 31  PHE   N CE2 1 
ATOM   186  C CZ  . PHE   A 1 69  ? 135.626 139.409 161.252 1.00 77.37  ? 31  PHE   N CZ  1 
ATOM   187  N N   . ARG   A 1 70  ? 136.606 141.816 165.889 1.00 81.04  ? 32  ARG   N N   1 
ATOM   188  C CA  . ARG   A 1 70  ? 136.678 140.592 166.673 1.00 77.70  ? 32  ARG   N CA  1 
ATOM   189  C C   . ARG   A 1 70  ? 137.842 140.697 167.648 1.00 72.80  ? 32  ARG   N C   1 
ATOM   190  O O   . ARG   A 1 70  ? 138.910 141.195 167.288 1.00 71.63  ? 32  ARG   N O   1 
ATOM   191  C CB  . ARG   A 1 70  ? 136.850 139.366 165.767 1.00 72.53  ? 32  ARG   N CB  1 
ATOM   192  C CG  . ARG   A 1 70  ? 136.820 138.039 166.495 1.00 77.22  ? 32  ARG   N CG  1 
ATOM   193  C CD  . ARG   A 1 70  ? 136.901 136.887 165.515 1.00 77.26  ? 32  ARG   N CD  1 
ATOM   194  N NE  . ARG   A 1 70  ? 136.966 135.596 166.188 1.00 81.15  ? 32  ARG   N NE  1 
ATOM   195  C CZ  . ARG   A 1 70  ? 135.906 134.894 166.563 1.00 82.11  ? 32  ARG   N CZ  1 
ATOM   196  N NH1 . ARG   A 1 70  ? 134.676 135.329 166.342 1.00 83.02  ? 32  ARG   N NH1 1 
ATOM   197  N NH2 . ARG   A 1 70  ? 136.084 133.726 167.173 1.00 79.88  ? 32  ARG   N NH2 1 
ATOM   198  N N   . LEU   A 1 71  ? 137.627 140.230 168.875 1.00 74.47  ? 33  LEU   N N   1 
ATOM   199  C CA  . LEU   A 1 71  ? 138.673 140.146 169.886 1.00 78.58  ? 33  LEU   N CA  1 
ATOM   200  C C   . LEU   A 1 71  ? 139.111 138.696 170.035 1.00 80.05  ? 33  LEU   N C   1 
ATOM   201  O O   . LEU   A 1 71  ? 138.270 137.800 170.152 1.00 81.89  ? 33  LEU   N O   1 
ATOM   202  C CB  . LEU   A 1 71  ? 138.191 140.688 171.233 1.00 83.82  ? 33  LEU   N CB  1 
ATOM   203  C CG  . LEU   A 1 71  ? 138.126 142.202 171.433 1.00 83.49  ? 33  LEU   N CG  1 
ATOM   204  C CD1 . LEU   A 1 71  ? 137.463 142.525 172.757 1.00 80.45  ? 33  LEU   N CD1 1 
ATOM   205  C CD2 . LEU   A 1 71  ? 139.513 142.808 171.380 1.00 81.76  ? 33  LEU   N CD2 1 
ATOM   206  N N   . TYR   A 1 72  ? 140.424 138.466 170.024 1.00 78.90  ? 34  TYR   N N   1 
ATOM   207  C CA  . TYR   A 1 72  ? 140.970 137.113 170.058 1.00 79.72  ? 34  TYR   N CA  1 
ATOM   208  C C   . TYR   A 1 72  ? 141.478 136.717 171.440 1.00 79.86  ? 34  TYR   N C   1 
ATOM   209  O O   . TYR   A 1 72  ? 140.995 135.744 172.025 1.00 85.60  ? 34  TYR   N O   1 
ATOM   210  C CB  . TYR   A 1 72  ? 142.090 136.983 169.019 1.00 78.07  ? 34  TYR   N CB  1 
ATOM   211  C CG  . TYR   A 1 72  ? 141.602 137.111 167.599 1.00 75.01  ? 34  TYR   N CG  1 
ATOM   212  C CD1 . TYR   A 1 72  ? 140.821 136.123 167.024 1.00 73.11  ? 34  TYR   N CD1 1 
ATOM   213  C CD2 . TYR   A 1 72  ? 141.913 138.224 166.837 1.00 77.10  ? 34  TYR   N CD2 1 
ATOM   214  C CE1 . TYR   A 1 72  ? 140.371 136.237 165.730 1.00 78.71  ? 34  TYR   N CE1 1 
ATOM   215  C CE2 . TYR   A 1 72  ? 141.467 138.347 165.542 1.00 77.25  ? 34  TYR   N CE2 1 
ATOM   216  C CZ  . TYR   A 1 72  ? 140.696 137.351 164.993 1.00 78.46  ? 34  TYR   N CZ  1 
ATOM   217  O OH  . TYR   A 1 72  ? 140.249 137.469 163.699 1.00 84.09  ? 34  TYR   N OH  1 
ATOM   218  N N   . ASP   A 1 73  ? 142.443 137.456 171.977 1.00 91.10  ? 35  ASP   N N   1 
ATOM   219  C CA  . ASP   A 1 73  ? 143.067 137.122 173.249 1.00 92.40  ? 35  ASP   N CA  1 
ATOM   220  C C   . ASP   A 1 73  ? 143.085 138.346 174.147 1.00 94.27  ? 35  ASP   N C   1 
ATOM   221  O O   . ASP   A 1 73  ? 143.421 139.446 173.702 1.00 102.50 ? 35  ASP   N O   1 
ATOM   222  C CB  . ASP   A 1 73  ? 144.500 136.612 173.056 1.00 94.99  ? 35  ASP   N CB  1 
ATOM   223  C CG  . ASP   A 1 73  ? 144.556 135.148 172.672 1.00 98.13  ? 35  ASP   N CG  1 
ATOM   224  O OD1 . ASP   A 1 73  ? 143.490 134.558 172.399 1.00 98.72  ? 35  ASP   N OD1 1 
ATOM   225  O OD2 . ASP   A 1 73  ? 145.670 134.586 172.644 1.00 99.07  ? 35  ASP   N OD2 1 
ATOM   226  N N   . MET   A 1 74  ? 142.727 138.150 175.413 1.00 96.30  ? 36  MET   N N   1 
ATOM   227  C CA  . MET   A 1 74  ? 142.770 139.206 176.414 1.00 99.10  ? 36  MET   N CA  1 
ATOM   228  C C   . MET   A 1 74  ? 143.460 138.666 177.654 1.00 101.35 ? 36  MET   N C   1 
ATOM   229  O O   . MET   A 1 74  ? 143.093 137.599 178.153 1.00 107.67 ? 36  MET   N O   1 
ATOM   230  C CB  . MET   A 1 74  ? 141.364 139.704 176.762 1.00 101.15 ? 36  MET   N CB  1 
ATOM   231  C CG  . MET   A 1 74  ? 140.539 140.136 175.562 1.00 102.52 ? 36  MET   N CG  1 
ATOM   232  S SD  . MET   A 1 74  ? 139.211 141.275 175.994 1.00 107.07 ? 36  MET   N SD  1 
ATOM   233  C CE  . MET   A 1 74  ? 140.140 142.601 176.760 1.00 103.09 ? 36  MET   N CE  1 
ATOM   234  N N   . GLY   A 1 75  ? 144.453 139.399 178.153 1.00 101.46 ? 37  GLY   N N   1 
ATOM   235  C CA  . GLY   A 1 75  ? 145.193 138.941 179.311 1.00 102.43 ? 37  GLY   N CA  1 
ATOM   236  C C   . GLY   A 1 75  ? 145.739 140.095 180.121 1.00 102.53 ? 37  GLY   N C   1 
ATOM   237  O O   . GLY   A 1 75  ? 145.722 141.250 179.695 1.00 108.27 ? 37  GLY   N O   1 
ATOM   238  N N   . TRP   A 1 76  ? 146.231 139.757 181.308 1.00 122.14 ? 38  TRP   N N   1 
ATOM   239  C CA  . TRP   A 1 76  ? 146.841 140.712 182.220 1.00 124.73 ? 38  TRP   N CA  1 
ATOM   240  C C   . TRP   A 1 76  ? 148.321 140.388 182.360 1.00 124.16 ? 38  TRP   N C   1 
ATOM   241  O O   . TRP   A 1 76  ? 148.696 139.226 182.534 1.00 127.08 ? 38  TRP   N O   1 
ATOM   242  C CB  . TRP   A 1 76  ? 146.163 140.681 183.592 1.00 125.19 ? 38  TRP   N CB  1 
ATOM   243  C CG  . TRP   A 1 76  ? 144.722 141.080 183.554 1.00 126.59 ? 38  TRP   N CG  1 
ATOM   244  C CD1 . TRP   A 1 76  ? 143.651 140.259 183.363 1.00 127.18 ? 38  TRP   N CD1 1 
ATOM   245  C CD2 . TRP   A 1 76  ? 144.192 142.400 183.713 1.00 127.15 ? 38  TRP   N CD2 1 
ATOM   246  N NE1 . TRP   A 1 76  ? 142.486 140.986 183.392 1.00 128.23 ? 38  TRP   N NE1 1 
ATOM   247  C CE2 . TRP   A 1 76  ? 142.792 142.304 183.605 1.00 127.65 ? 38  TRP   N CE2 1 
ATOM   248  C CE3 . TRP   A 1 76  ? 144.766 143.654 183.935 1.00 127.07 ? 38  TRP   N CE3 1 
ATOM   249  C CZ2 . TRP   A 1 76  ? 141.959 143.413 183.711 1.00 127.26 ? 38  TRP   N CZ2 1 
ATOM   250  C CZ3 . TRP   A 1 76  ? 143.937 144.753 184.041 1.00 126.97 ? 38  TRP   N CZ3 1 
ATOM   251  C CH2 . TRP   A 1 76  ? 142.549 144.626 183.928 1.00 126.39 ? 38  TRP   N CH2 1 
ATOM   252  N N   . TYR   A 1 77  ? 149.157 141.418 182.282 1.00 122.38 ? 39  TYR   N N   1 
ATOM   253  C CA  . TYR   A 1 77  ? 150.601 141.245 182.260 1.00 123.09 ? 39  TYR   N CA  1 
ATOM   254  C C   . TYR   A 1 77  ? 151.228 142.015 183.415 1.00 124.26 ? 39  TYR   N C   1 
ATOM   255  O O   . TYR   A 1 77  ? 150.539 142.635 184.230 1.00 127.24 ? 39  TYR   N O   1 
ATOM   256  C CB  . TYR   A 1 77  ? 151.191 141.704 180.922 1.00 124.90 ? 39  TYR   N CB  1 
ATOM   257  C CG  . TYR   A 1 77  ? 151.029 140.703 179.803 1.00 123.19 ? 39  TYR   N CG  1 
ATOM   258  C CD1 . TYR   A 1 77  ? 149.781 140.435 179.259 1.00 121.54 ? 39  TYR   N CD1 1 
ATOM   259  C CD2 . TYR   A 1 77  ? 152.126 140.024 179.292 1.00 123.18 ? 39  TYR   N CD2 1 
ATOM   260  C CE1 . TYR   A 1 77  ? 149.630 139.522 178.236 1.00 122.84 ? 39  TYR   N CE1 1 
ATOM   261  C CE2 . TYR   A 1 77  ? 151.985 139.109 178.270 1.00 123.51 ? 39  TYR   N CE2 1 
ATOM   262  C CZ  . TYR   A 1 77  ? 150.735 138.862 177.745 1.00 124.15 ? 39  TYR   N CZ  1 
ATOM   263  O OH  . TYR   A 1 77  ? 150.591 137.950 176.726 1.00 125.04 ? 39  TYR   N OH  1 
ATOM   264  N N   . ARG   A 1 78  ? 152.555 141.965 183.476 1.00 136.81 ? 40  ARG   N N   1 
ATOM   265  C CA  . ARG   A 1 78  ? 153.323 142.669 184.494 1.00 138.32 ? 40  ARG   N CA  1 
ATOM   266  C C   . ARG   A 1 78  ? 154.792 142.742 184.090 1.00 138.72 ? 40  ARG   N C   1 
ATOM   267  O O   . ARG   A 1 78  ? 155.415 143.800 184.169 1.00 140.07 ? 40  ARG   N O   1 
ATOM   268  C CB  . ARG   A 1 78  ? 153.181 141.981 185.854 1.00 138.14 ? 40  ARG   N CB  1 
ATOM   269  C CG  . ARG   A 1 78  ? 154.172 142.454 186.908 1.00 137.87 ? 40  ARG   N CG  1 
ATOM   270  C CD  . ARG   A 1 78  ? 154.034 143.942 187.194 1.00 139.11 ? 40  ARG   N CD  1 
ATOM   271  N NE  . ARG   A 1 78  ? 154.990 144.735 186.430 1.00 139.68 ? 40  ARG   N NE  1 
ATOM   272  C CZ  . ARG   A 1 78  ? 154.973 146.058 186.348 1.00 139.78 ? 40  ARG   N CZ  1 
ATOM   273  N NH1 . ARG   A 1 78  ? 154.062 146.778 186.982 1.00 140.53 ? 40  ARG   N NH1 1 
ATOM   274  N NH2 . ARG   A 1 78  ? 155.893 146.675 185.613 1.00 138.94 ? 40  ARG   N NH2 1 
ATOM   275  N N   . GLN   A 1 84  ? 160.021 141.050 180.773 1.00 141.88 ? 46  GLN   N N   1 
ATOM   276  C CA  . GLN   A 1 84  ? 159.540 142.259 181.431 1.00 143.58 ? 46  GLN   N CA  1 
ATOM   277  C C   . GLN   A 1 84  ? 158.051 142.157 181.741 1.00 144.19 ? 46  GLN   N C   1 
ATOM   278  O O   . GLN   A 1 84  ? 157.639 142.259 182.897 1.00 143.46 ? 46  GLN   N O   1 
ATOM   279  C CB  . GLN   A 1 84  ? 159.812 143.488 180.561 1.00 143.11 ? 46  GLN   N CB  1 
ATOM   280  C CG  . GLN   A 1 84  ? 161.136 144.174 180.855 1.00 142.76 ? 46  GLN   N CG  1 
ATOM   281  C CD  . GLN   A 1 84  ? 161.085 145.028 182.107 1.00 142.41 ? 46  GLN   N CD  1 
ATOM   282  O OE1 . GLN   A 1 84  ? 160.012 145.292 182.650 1.00 141.68 ? 46  GLN   N OE1 1 
ATOM   283  N NE2 . GLN   A 1 84  ? 162.250 145.465 182.571 1.00 141.65 ? 46  GLN   N NE2 1 
ATOM   284  N N   . ARG   A 1 85  ? 157.246 141.957 180.697 1.00 141.66 ? 47  ARG   N N   1 
ATOM   285  C CA  . ARG   A 1 85  ? 155.797 141.833 180.844 1.00 140.48 ? 47  ARG   N CA  1 
ATOM   286  C C   . ARG   A 1 85  ? 155.463 140.381 181.178 1.00 137.77 ? 47  ARG   N C   1 
ATOM   287  O O   . ARG   A 1 85  ? 155.117 139.567 180.319 1.00 135.97 ? 47  ARG   N O   1 
ATOM   288  C CB  . ARG   A 1 85  ? 155.088 142.309 179.582 1.00 139.60 ? 47  ARG   N CB  1 
ATOM   289  C CG  . ARG   A 1 85  ? 154.423 143.671 179.726 1.00 138.16 ? 47  ARG   N CG  1 
ATOM   290  C CD  . ARG   A 1 85  ? 155.381 144.696 180.310 1.00 138.83 ? 47  ARG   N CD  1 
ATOM   291  N NE  . ARG   A 1 85  ? 154.762 146.007 180.463 1.00 139.15 ? 47  ARG   N NE  1 
ATOM   292  C CZ  . ARG   A 1 85  ? 155.368 147.064 180.987 1.00 139.51 ? 47  ARG   N CZ  1 
ATOM   293  N NH1 . ARG   A 1 85  ? 156.614 146.998 181.428 1.00 139.65 ? 47  ARG   N NH1 1 
ATOM   294  N NH2 . ARG   A 1 85  ? 154.708 148.215 181.072 1.00 137.58 ? 47  ARG   N NH2 1 
ATOM   295  N N   . GLU   A 1 86  ? 155.576 140.061 182.464 1.00 138.30 ? 48  GLU   N N   1 
ATOM   296  C CA  . GLU   A 1 86  ? 155.268 138.719 182.938 1.00 139.84 ? 48  GLU   N CA  1 
ATOM   297  C C   . GLU   A 1 86  ? 153.777 138.442 182.806 1.00 140.31 ? 48  GLU   N C   1 
ATOM   298  O O   . GLU   A 1 86  ? 152.945 139.255 183.220 1.00 142.67 ? 48  GLU   N O   1 
ATOM   299  C CB  . GLU   A 1 86  ? 155.704 138.561 184.394 1.00 139.89 ? 48  GLU   N CB  1 
ATOM   300  C CG  . GLU   A 1 86  ? 155.385 137.203 184.996 1.00 138.53 ? 48  GLU   N CG  1 
ATOM   301  C CD  . GLU   A 1 86  ? 155.745 137.120 186.466 1.00 138.98 ? 48  GLU   N CD  1 
ATOM   302  O OE1 . GLU   A 1 86  ? 156.209 138.135 187.024 1.00 139.41 ? 48  GLU   N OE1 1 
ATOM   303  O OE2 . GLU   A 1 86  ? 155.562 136.039 187.065 1.00 139.35 ? 48  GLU   N OE2 1 
ATOM   304  N N   . LEU   A 1 87  ? 153.437 137.289 182.234 1.00 127.48 ? 49  LEU   N N   1 
ATOM   305  C CA  . LEU   A 1 87  ? 152.042 136.891 182.085 1.00 126.40 ? 49  LEU   N CA  1 
ATOM   306  C C   . LEU   A 1 87  ? 151.546 136.348 183.419 1.00 126.93 ? 49  LEU   N C   1 
ATOM   307  O O   . LEU   A 1 87  ? 152.016 135.306 183.886 1.00 129.15 ? 49  LEU   N O   1 
ATOM   308  C CB  . LEU   A 1 87  ? 151.896 135.852 180.978 1.00 125.05 ? 49  LEU   N CB  1 
ATOM   309  N N   . VAL   A 1 88  ? 150.598 137.051 184.034 1.00 125.86 ? 50  VAL   N N   1 
ATOM   310  C CA  . VAL   A 1 88  ? 150.054 136.637 185.321 1.00 125.94 ? 50  VAL   N CA  1 
ATOM   311  C C   . VAL   A 1 88  ? 148.709 135.958 185.098 1.00 126.21 ? 50  VAL   N C   1 
ATOM   312  O O   . VAL   A 1 88  ? 148.288 135.112 185.894 1.00 128.72 ? 50  VAL   N O   1 
ATOM   313  C CB  . VAL   A 1 88  ? 149.936 137.832 186.288 1.00 125.46 ? 50  VAL   N CB  1 
ATOM   314  C CG1 . VAL   A 1 88  ? 148.893 138.826 185.801 1.00 125.47 ? 50  VAL   N CG1 1 
ATOM   315  C CG2 . VAL   A 1 88  ? 149.616 137.355 187.696 1.00 127.34 ? 50  VAL   N CG2 1 
ATOM   316  N N   . ALA   A 1 89  ? 148.033 136.314 184.005 1.00 113.62 ? 51  ALA   N N   1 
ATOM   317  C CA  . ALA   A 1 89  ? 146.757 135.705 183.653 1.00 113.51 ? 51  ALA   N CA  1 
ATOM   318  C C   . ALA   A 1 89  ? 146.396 136.020 182.208 1.00 114.07 ? 51  ALA   N C   1 
ATOM   319  O O   . ALA   A 1 89  ? 146.383 137.188 181.807 1.00 118.48 ? 51  ALA   N O   1 
ATOM   320  C CB  . ALA   A 1 89  ? 145.648 136.186 184.591 1.00 114.38 ? 51  ALA   N CB  1 
ATOM   321  N N   . SER   A 1 90  ? 146.104 134.990 181.418 1.00 101.93 ? 52  SER   N N   1 
ATOM   322  C CA  . SER   A 1 90  ? 145.720 135.170 180.025 1.00 99.96  ? 52  SER   N CA  1 
ATOM   323  C C   . SER   A 1 90  ? 144.595 134.206 179.689 1.00 100.01 ? 52  SER   N C   1 
ATOM   324  O O   . SER   A 1 90  ? 144.723 133.000 179.916 1.00 106.18 ? 52  SER   N O   1 
ATOM   325  C CB  . SER   A 1 90  ? 146.910 134.942 179.087 1.00 99.83  ? 52  SER   N CB  1 
ATOM   326  N N   . ILE   A 1 91  ? 143.502 134.735 179.149 1.00 102.61 ? 53  ILE   N N   1 
ATOM   327  C CA  . ILE   A 1 91  ? 142.352 133.937 178.745 1.00 103.07 ? 53  ILE   N CA  1 
ATOM   328  C C   . ILE   A 1 91  ? 142.085 134.191 177.269 1.00 104.33 ? 53  ILE   N C   1 
ATOM   329  O O   . ILE   A 1 91  ? 142.036 135.345 176.829 1.00 105.26 ? 53  ILE   N O   1 
ATOM   330  C CB  . ILE   A 1 91  ? 141.107 134.252 179.597 1.00 105.50 ? 53  ILE   N CB  1 
ATOM   331  C CG1 . ILE   A 1 91  ? 139.895 133.472 179.084 1.00 107.01 ? 53  ILE   N CG1 1 
ATOM   332  C CG2 . ILE   A 1 91  ? 140.824 135.746 179.629 1.00 106.14 ? 53  ILE   N CG2 1 
ATOM   333  C CD1 . ILE   A 1 91  ? 138.707 133.506 180.020 1.00 110.11 ? 53  ILE   N CD1 1 
ATOM   334  N N   . THR   A 1 92  ? 141.932 133.115 176.505 1.00 105.86 ? 54  THR   N N   1 
ATOM   335  C CA  . THR   A 1 92  ? 141.629 133.233 175.089 1.00 105.05 ? 54  THR   N CA  1 
ATOM   336  C C   . THR   A 1 92  ? 140.132 133.457 174.895 1.00 105.28 ? 54  THR   N C   1 
ATOM   337  O O   . THR   A 1 92  ? 139.357 133.534 175.851 1.00 107.48 ? 54  THR   N O   1 
ATOM   338  C CB  . THR   A 1 92  ? 142.099 131.992 174.337 1.00 104.52 ? 54  THR   N CB  1 
ATOM   339  O OG1 . THR   A 1 92  ? 141.406 130.841 174.833 1.00 104.85 ? 54  THR   N OG1 1 
ATOM   340  C CG2 . THR   A 1 92  ? 143.594 131.794 174.525 1.00 103.87 ? 54  THR   N CG2 1 
ATOM   341  N N   . SER   A 1 93  ? 139.717 133.573 173.632 1.00 102.51 ? 55  SER   N N   1 
ATOM   342  C CA  . SER   A 1 93  ? 138.298 133.743 173.343 1.00 102.09 ? 55  SER   N CA  1 
ATOM   343  C C   . SER   A 1 93  ? 137.504 132.490 173.685 1.00 103.68 ? 55  SER   N C   1 
ATOM   344  O O   . SER   A 1 93  ? 136.314 132.580 174.007 1.00 101.96 ? 55  SER   N O   1 
ATOM   345  C CB  . SER   A 1 93  ? 138.102 134.120 171.876 1.00 101.48 ? 55  SER   N CB  1 
ATOM   346  O OG  . SER   A 1 93  ? 138.878 133.290 171.031 1.00 104.13 ? 55  SER   N OG  1 
ATOM   347  N N   . GLY   A 1 94  ? 138.140 131.320 173.623 1.00 108.62 ? 56  GLY   N N   1 
ATOM   348  C CA  . GLY   A 1 94  ? 137.482 130.079 173.985 1.00 108.65 ? 56  GLY   N CA  1 
ATOM   349  C C   . GLY   A 1 94  ? 137.479 129.758 175.462 1.00 108.57 ? 56  GLY   N C   1 
ATOM   350  O O   . GLY   A 1 94  ? 136.842 128.781 175.867 1.00 109.61 ? 56  GLY   N O   1 
ATOM   351  N N   . GLY   A 1 95  ? 138.172 130.549 176.274 1.00 108.48 ? 57  GLY   N N   1 
ATOM   352  C CA  . GLY   A 1 95  ? 138.230 130.326 177.702 1.00 107.51 ? 57  GLY   N CA  1 
ATOM   353  C C   . GLY   A 1 95  ? 139.438 129.565 178.200 1.00 108.72 ? 57  GLY   N C   1 
ATOM   354  O O   . GLY   A 1 95  ? 139.469 129.201 179.381 1.00 110.80 ? 57  GLY   N O   1 
ATOM   355  N N   . SER   A 1 96  ? 140.432 129.318 177.350 1.00 107.86 ? 58  SER   N N   1 
ATOM   356  C CA  . SER   A 1 96  ? 141.609 128.561 177.759 1.00 108.65 ? 58  SER   N CA  1 
ATOM   357  C C   . SER   A 1 96  ? 142.523 129.408 178.636 1.00 108.02 ? 58  SER   N C   1 
ATOM   358  O O   . SER   A 1 96  ? 143.483 130.010 178.145 1.00 107.52 ? 58  SER   N O   1 
ATOM   359  C CB  . SER   A 1 96  ? 142.371 128.052 176.534 1.00 107.12 ? 58  SER   N CB  1 
ATOM   360  N N   . THR   A 1 97  ? 142.232 129.455 179.932 1.00 111.12 ? 59  THR   N N   1 
ATOM   361  C CA  . THR   A 1 97  ? 143.030 130.252 180.852 1.00 111.21 ? 59  THR   N CA  1 
ATOM   362  C C   . THR   A 1 97  ? 144.406 129.629 181.051 1.00 111.23 ? 59  THR   N C   1 
ATOM   363  O O   . THR   A 1 97  ? 144.550 128.406 181.119 1.00 111.39 ? 59  THR   N O   1 
ATOM   364  C CB  . THR   A 1 97  ? 142.319 130.380 182.198 1.00 112.70 ? 59  THR   N CB  1 
ATOM   365  O OG1 . THR   A 1 97  ? 142.365 129.123 182.884 1.00 113.06 ? 59  THR   N OG1 1 
ATOM   366  C CG2 . THR   A 1 97  ? 140.867 130.780 181.992 1.00 112.50 ? 59  THR   N CG2 1 
ATOM   367  N N   . LYS   A 1 98  ? 145.425 130.483 181.143 1.00 113.37 ? 60  LYS   N N   1 
ATOM   368  C CA  . LYS   A 1 98  ? 146.807 130.058 181.372 1.00 113.77 ? 60  LYS   N CA  1 
ATOM   369  C C   . LYS   A 1 98  ? 147.383 130.944 182.472 1.00 115.13 ? 60  LYS   N C   1 
ATOM   370  O O   . LYS   A 1 98  ? 148.000 131.974 182.192 1.00 117.15 ? 60  LYS   N O   1 
ATOM   371  C CB  . LYS   A 1 98  ? 147.629 130.137 180.090 1.00 112.16 ? 60  LYS   N CB  1 
ATOM   372  N N   . TYR   A 1 99  ? 147.186 130.533 183.721 1.00 127.05 ? 61  TYR   N N   1 
ATOM   373  C CA  . TYR   A 1 99  ? 147.650 131.318 184.853 1.00 127.25 ? 61  TYR   N CA  1 
ATOM   374  C C   . TYR   A 1 99  ? 149.165 131.212 185.000 1.00 128.55 ? 61  TYR   N C   1 
ATOM   375  O O   . TYR   A 1 99  ? 149.806 130.284 184.498 1.00 127.58 ? 61  TYR   N O   1 
ATOM   376  C CB  . TYR   A 1 99  ? 146.965 130.858 186.139 1.00 128.04 ? 61  TYR   N CB  1 
ATOM   377  C CG  . TYR   A 1 99  ? 145.465 131.039 186.129 1.00 128.42 ? 61  TYR   N CG  1 
ATOM   378  C CD1 . TYR   A 1 99  ? 144.899 132.304 186.184 1.00 129.25 ? 61  TYR   N CD1 1 
ATOM   379  C CD2 . TYR   A 1 99  ? 144.615 129.944 186.061 1.00 129.15 ? 61  TYR   N CD2 1 
ATOM   380  C CE1 . TYR   A 1 99  ? 143.528 132.474 186.174 1.00 129.24 ? 61  TYR   N CE1 1 
ATOM   381  C CE2 . TYR   A 1 99  ? 143.244 130.105 186.051 1.00 128.75 ? 61  TYR   N CE2 1 
ATOM   382  C CZ  . TYR   A 1 99  ? 142.706 131.371 186.107 1.00 128.66 ? 61  TYR   N CZ  1 
ATOM   383  O OH  . TYR   A 1 99  ? 141.341 131.535 186.098 1.00 127.69 ? 61  TYR   N OH  1 
ATOM   384  N N   . GLY   A 1 100 ? 149.737 132.188 185.701 1.00 140.98 ? 62  GLY   N N   1 
ATOM   385  C CA  . GLY   A 1 100 ? 151.165 132.231 185.923 1.00 141.53 ? 62  GLY   N CA  1 
ATOM   386  C C   . GLY   A 1 100 ? 151.611 131.318 187.049 1.00 143.58 ? 62  GLY   N C   1 
ATOM   387  O O   . GLY   A 1 100 ? 150.814 130.686 187.743 1.00 143.75 ? 62  GLY   N O   1 
ATOM   388  N N   . ASP   A 1 101 ? 152.933 131.252 187.222 1.00 150.10 ? 63  ASP   N N   1 
ATOM   389  C CA  . ASP   A 1 101 ? 153.503 130.407 188.267 1.00 150.43 ? 63  ASP   N CA  1 
ATOM   390  C C   . ASP   A 1 101 ? 153.112 130.895 189.656 1.00 150.63 ? 63  ASP   N C   1 
ATOM   391  O O   . ASP   A 1 101 ? 152.790 130.089 190.536 1.00 150.43 ? 63  ASP   N O   1 
ATOM   392  C CB  . ASP   A 1 101 ? 155.024 130.354 188.125 1.00 148.76 ? 63  ASP   N CB  1 
ATOM   393  N N   . SER   A 1 102 ? 153.131 132.208 189.873 1.00 148.72 ? 64  SER   N N   1 
ATOM   394  C CA  . SER   A 1 102 ? 152.806 132.791 191.167 1.00 147.80 ? 64  SER   N CA  1 
ATOM   395  C C   . SER   A 1 102 ? 151.334 133.165 191.293 1.00 149.51 ? 64  SER   N C   1 
ATOM   396  O O   . SER   A 1 102 ? 150.939 133.740 192.313 1.00 149.59 ? 64  SER   N O   1 
ATOM   397  C CB  . SER   A 1 102 ? 153.677 134.023 191.423 1.00 147.07 ? 64  SER   N CB  1 
ATOM   398  N N   . VAL   A 1 103 ? 150.519 132.854 190.288 1.00 154.65 ? 65  VAL   N N   1 
ATOM   399  C CA  . VAL   A 1 103 ? 149.102 133.195 190.287 1.00 153.96 ? 65  VAL   N CA  1 
ATOM   400  C C   . VAL   A 1 103 ? 148.227 131.973 190.527 1.00 154.50 ? 65  VAL   N C   1 
ATOM   401  O O   . VAL   A 1 103 ? 147.002 132.059 190.398 1.00 153.74 ? 65  VAL   N O   1 
ATOM   402  C CB  . VAL   A 1 103 ? 148.701 133.904 188.984 1.00 151.95 ? 65  VAL   N CB  1 
ATOM   403  N N   . LYS   A 1 104 ? 148.823 130.835 190.871 1.00 159.43 ? 66  LYS   N N   1 
ATOM   404  C CA  . LYS   A 1 104 ? 148.057 129.617 191.091 1.00 159.71 ? 66  LYS   N CA  1 
ATOM   405  C C   . LYS   A 1 104 ? 147.329 129.687 192.427 1.00 159.73 ? 66  LYS   N C   1 
ATOM   406  O O   . LYS   A 1 104 ? 147.951 129.890 193.475 1.00 158.34 ? 66  LYS   N O   1 
ATOM   407  C CB  . LYS   A 1 104 ? 148.975 128.396 191.051 1.00 158.20 ? 66  LYS   N CB  1 
ATOM   408  N N   . GLY   A 1 105 ? 146.008 129.522 192.387 1.00 160.29 ? 67  GLY   N N   1 
ATOM   409  C CA  . GLY   A 1 105 ? 145.197 129.499 193.585 1.00 158.99 ? 67  GLY   N CA  1 
ATOM   410  C C   . GLY   A 1 105 ? 144.794 130.851 194.128 1.00 159.42 ? 67  GLY   N C   1 
ATOM   411  O O   . GLY   A 1 105 ? 143.961 130.907 195.042 1.00 159.12 ? 67  GLY   N O   1 
ATOM   412  N N   . ARG   A 1 106 ? 145.349 131.944 193.605 1.00 160.77 ? 68  ARG   N N   1 
ATOM   413  C CA  . ARG   A 1 106 ? 145.033 133.278 194.095 1.00 160.55 ? 68  ARG   N CA  1 
ATOM   414  C C   . ARG   A 1 106 ? 144.292 134.144 193.090 1.00 160.46 ? 68  ARG   N C   1 
ATOM   415  O O   . ARG   A 1 106 ? 143.494 134.990 193.498 1.00 160.70 ? 68  ARG   N O   1 
ATOM   416  C CB  . ARG   A 1 106 ? 146.313 134.007 194.521 1.00 160.96 ? 68  ARG   N CB  1 
ATOM   417  C CG  . ARG   A 1 106 ? 146.767 133.688 195.935 1.00 160.99 ? 68  ARG   N CG  1 
ATOM   418  C CD  . ARG   A 1 106 ? 148.006 134.482 196.313 1.00 160.44 ? 68  ARG   N CD  1 
ATOM   419  N NE  . ARG   A 1 106 ? 149.189 134.043 195.583 1.00 161.03 ? 68  ARG   N NE  1 
ATOM   420  C CZ  . ARG   A 1 106 ? 150.204 134.832 195.260 1.00 160.96 ? 68  ARG   N CZ  1 
ATOM   421  N NH1 . ARG   A 1 106 ? 150.213 136.114 195.585 1.00 161.09 ? 68  ARG   N NH1 1 
ATOM   422  N NH2 . ARG   A 1 106 ? 151.236 134.321 194.594 1.00 160.82 ? 68  ARG   N NH2 1 
ATOM   423  N N   . PHE   A 1 107 ? 144.533 133.962 191.794 1.00 154.97 ? 69  PHE   N N   1 
ATOM   424  C CA  . PHE   A 1 107 ? 143.928 134.786 190.756 1.00 154.51 ? 69  PHE   N CA  1 
ATOM   425  C C   . PHE   A 1 107 ? 143.042 133.922 189.872 1.00 153.28 ? 69  PHE   N C   1 
ATOM   426  O O   . PHE   A 1 107 ? 143.472 132.866 189.398 1.00 152.87 ? 69  PHE   N O   1 
ATOM   427  C CB  . PHE   A 1 107 ? 144.998 135.480 189.906 1.00 155.42 ? 69  PHE   N CB  1 
ATOM   428  C CG  . PHE   A 1 107 ? 145.836 136.468 190.667 1.00 155.79 ? 69  PHE   N CG  1 
ATOM   429  C CD1 . PHE   A 1 107 ? 145.402 136.988 191.875 1.00 156.02 ? 69  PHE   N CD1 1 
ATOM   430  C CD2 . PHE   A 1 107 ? 147.064 136.875 190.173 1.00 154.81 ? 69  PHE   N CD2 1 
ATOM   431  C CE1 . PHE   A 1 107 ? 146.177 137.892 192.574 1.00 155.99 ? 69  PHE   N CE1 1 
ATOM   432  C CE2 . PHE   A 1 107 ? 147.842 137.780 190.867 1.00 155.32 ? 69  PHE   N CE2 1 
ATOM   433  C CZ  . PHE   A 1 107 ? 147.398 138.288 192.069 1.00 155.74 ? 69  PHE   N CZ  1 
ATOM   434  N N   . THR   A 1 108 ? 141.808 134.373 189.655 1.00 140.79 ? 70  THR   N N   1 
ATOM   435  C CA  . THR   A 1 108 ? 140.875 133.715 188.752 1.00 141.92 ? 70  THR   N CA  1 
ATOM   436  C C   . THR   A 1 108 ? 140.365 134.739 187.752 1.00 141.58 ? 70  THR   N C   1 
ATOM   437  O O   . THR   A 1 108 ? 139.864 135.797 188.146 1.00 141.07 ? 70  THR   N O   1 
ATOM   438  C CB  . THR   A 1 108 ? 139.703 133.086 189.515 1.00 142.29 ? 70  THR   N CB  1 
ATOM   439  O OG1 . THR   A 1 108 ? 140.176 131.977 190.290 1.00 142.54 ? 70  THR   N OG1 1 
ATOM   440  C CG2 . THR   A 1 108 ? 138.635 132.602 188.546 1.00 141.39 ? 70  THR   N CG2 1 
ATOM   441  N N   . ILE   A 1 109 ? 140.489 134.425 186.467 1.00 130.66 ? 71  ILE   N N   1 
ATOM   442  C CA  . ILE   A 1 109 ? 140.148 135.356 185.407 1.00 129.63 ? 71  ILE   N CA  1 
ATOM   443  C C   . ILE   A 1 109 ? 138.776 135.006 184.848 1.00 128.92 ? 71  ILE   N C   1 
ATOM   444  O O   . ILE   A 1 109 ? 138.289 133.877 184.965 1.00 129.35 ? 71  ILE   N O   1 
ATOM   445  C CB  . ILE   A 1 109 ? 141.221 135.366 184.293 1.00 129.63 ? 71  ILE   N CB  1 
ATOM   446  C CG1 . ILE   A 1 109 ? 141.242 136.718 183.580 1.00 129.85 ? 71  ILE   N CG1 1 
ATOM   447  C CG2 . ILE   A 1 109 ? 140.981 134.239 183.303 1.00 127.14 ? 71  ILE   N CG2 1 
ATOM   448  C CD1 . ILE   A 1 109 ? 142.446 136.918 182.692 1.00 128.66 ? 71  ILE   N CD1 1 
ATOM   449  N N   . SER   A 1 110 ? 138.134 136.000 184.239 1.00 122.50 ? 72  SER   N N   1 
ATOM   450  C CA  . SER   A 1 110 ? 136.832 135.819 183.617 1.00 122.21 ? 72  SER   N CA  1 
ATOM   451  C C   . SER   A 1 110 ? 136.745 136.737 182.409 1.00 120.48 ? 72  SER   N C   1 
ATOM   452  O O   . SER   A 1 110 ? 137.456 137.740 182.316 1.00 120.31 ? 72  SER   N O   1 
ATOM   453  C CB  . SER   A 1 110 ? 135.690 136.105 184.599 1.00 123.95 ? 72  SER   N CB  1 
ATOM   454  O OG  . SER   A 1 110 ? 134.429 135.974 183.968 1.00 122.66 ? 72  SER   N OG  1 
ATOM   455  N N   . ARG   A 1 111 ? 135.862 136.384 181.479 1.00 111.03 ? 73  ARG   N N   1 
ATOM   456  C CA  . ARG   A 1 111 ? 135.732 137.124 180.233 1.00 111.31 ? 73  ARG   N CA  1 
ATOM   457  C C   . ARG   A 1 111 ? 134.269 137.224 179.835 1.00 111.26 ? 73  ARG   N C   1 
ATOM   458  O O   . ARG   A 1 111 ? 133.514 136.257 179.963 1.00 112.45 ? 73  ARG   N O   1 
ATOM   459  C CB  . ARG   A 1 111 ? 136.537 136.457 179.110 1.00 109.69 ? 73  ARG   N CB  1 
ATOM   460  C CG  . ARG   A 1 111 ? 136.468 137.177 177.777 1.00 109.09 ? 73  ARG   N CG  1 
ATOM   461  C CD  . ARG   A 1 111 ? 137.493 136.619 176.809 1.00 110.20 ? 73  ARG   N CD  1 
ATOM   462  N NE  . ARG   A 1 111 ? 137.363 137.198 175.478 1.00 111.29 ? 73  ARG   N NE  1 
ATOM   463  C CZ  . ARG   A 1 111 ? 138.321 137.182 174.562 1.00 109.91 ? 73  ARG   N CZ  1 
ATOM   464  N NH1 . ARG   A 1 111 ? 139.498 136.631 174.803 1.00 111.97 ? 73  ARG   N NH1 1 
ATOM   465  N NH2 . ARG   A 1 111 ? 138.090 137.732 173.374 1.00 108.61 ? 73  ARG   N NH2 1 
ATOM   466  N N   . ASP   A 1 112 ? 133.879 138.399 179.351 1.00 117.11 ? 74  ASP   N N   1 
ATOM   467  C CA  . ASP   A 1 112 ? 132.549 138.639 178.796 1.00 117.65 ? 74  ASP   N CA  1 
ATOM   468  C C   . ASP   A 1 112 ? 132.741 139.157 177.375 1.00 116.88 ? 74  ASP   N C   1 
ATOM   469  O O   . ASP   A 1 112 ? 132.954 140.355 177.168 1.00 119.61 ? 74  ASP   N O   1 
ATOM   470  C CB  . ASP   A 1 112 ? 131.761 139.626 179.652 1.00 119.98 ? 74  ASP   N CB  1 
ATOM   471  C CG  . ASP   A 1 112 ? 130.322 139.777 179.195 1.00 119.74 ? 74  ASP   N CG  1 
ATOM   472  O OD1 . ASP   A 1 112 ? 129.897 139.023 178.295 1.00 118.97 ? 74  ASP   N OD1 1 
ATOM   473  O OD2 . ASP   A 1 112 ? 129.615 140.651 179.737 1.00 119.86 ? 74  ASP   N OD2 1 
ATOM   474  N N   . ASN   A 1 113 ? 132.667 138.252 176.397 1.00 115.85 ? 75  ASN   N N   1 
ATOM   475  C CA  . ASN   A 1 113 ? 132.879 138.647 175.009 1.00 116.99 ? 75  ASN   N CA  1 
ATOM   476  C C   . ASN   A 1 113 ? 131.789 139.589 174.517 1.00 118.89 ? 75  ASN   N C   1 
ATOM   477  O O   . ASN   A 1 113 ? 132.052 140.443 173.662 1.00 118.38 ? 75  ASN   N O   1 
ATOM   478  C CB  . ASN   A 1 113 ? 132.953 137.410 174.117 1.00 116.74 ? 75  ASN   N CB  1 
ATOM   479  C CG  . ASN   A 1 113 ? 134.162 136.550 174.416 1.00 118.56 ? 75  ASN   N CG  1 
ATOM   480  O OD1 . ASN   A 1 113 ? 135.299 136.951 174.168 1.00 119.61 ? 75  ASN   N OD1 1 
ATOM   481  N ND2 . ASN   A 1 113 ? 133.924 135.361 174.956 1.00 119.43 ? 75  ASN   N ND2 1 
ATOM   482  N N   . ALA   A 1 114 ? 130.566 139.446 175.032 1.00 124.44 ? 76  ALA   N N   1 
ATOM   483  C CA  . ALA   A 1 114 ? 129.481 140.330 174.617 1.00 123.58 ? 76  ALA   N CA  1 
ATOM   484  C C   . ALA   A 1 114 ? 129.766 141.774 175.008 1.00 124.02 ? 76  ALA   N C   1 
ATOM   485  O O   . ALA   A 1 114 ? 129.497 142.700 174.235 1.00 123.25 ? 76  ALA   N O   1 
ATOM   486  C CB  . ALA   A 1 114 ? 128.159 139.859 175.221 1.00 123.30 ? 76  ALA   N CB  1 
ATOM   487  N N   . LYS   A 1 115 ? 130.309 141.986 176.204 1.00 119.98 ? 77  LYS   N N   1 
ATOM   488  C CA  . LYS   A 1 115 ? 130.642 143.322 176.679 1.00 120.39 ? 77  LYS   N CA  1 
ATOM   489  C C   . LYS   A 1 115 ? 132.047 143.760 176.289 1.00 121.93 ? 77  LYS   N C   1 
ATOM   490  O O   . LYS   A 1 115 ? 132.424 144.900 176.580 1.00 121.00 ? 77  LYS   N O   1 
ATOM   491  C CB  . LYS   A 1 115 ? 130.487 143.392 178.202 1.00 119.04 ? 77  LYS   N CB  1 
ATOM   492  N N   . ASN   A 1 116 ? 132.821 142.890 175.634 1.00 116.38 ? 78  ASN   N N   1 
ATOM   493  C CA  . ASN   A 1 116 ? 134.194 143.194 175.225 1.00 113.46 ? 78  ASN   N CA  1 
ATOM   494  C C   . ASN   A 1 116 ? 135.057 143.587 176.423 1.00 112.40 ? 78  ASN   N C   1 
ATOM   495  O O   . ASN   A 1 116 ? 135.841 144.535 176.362 1.00 112.15 ? 78  ASN   N O   1 
ATOM   496  C CB  . ASN   A 1 116 ? 134.223 144.288 174.155 1.00 111.91 ? 78  ASN   N CB  1 
ATOM   497  C CG  . ASN   A 1 116 ? 134.176 143.728 172.749 1.00 112.79 ? 78  ASN   N CG  1 
ATOM   498  O OD1 . ASN   A 1 116 ? 134.154 142.514 172.552 1.00 114.34 ? 78  ASN   N OD1 1 
ATOM   499  N ND2 . ASN   A 1 116 ? 134.159 144.613 171.761 1.00 112.86 ? 78  ASN   N ND2 1 
ATOM   500  N N   . THR   A 1 117 ? 134.910 142.851 177.523 1.00 115.67 ? 79  THR   N N   1 
ATOM   501  C CA  . THR   A 1 117 ? 135.624 143.134 178.759 1.00 115.40 ? 79  THR   N CA  1 
ATOM   502  C C   . THR   A 1 117 ? 136.230 141.856 179.320 1.00 115.11 ? 79  THR   N C   1 
ATOM   503  O O   . THR   A 1 117 ? 135.743 140.752 179.064 1.00 116.52 ? 79  THR   N O   1 
ATOM   504  C CB  . THR   A 1 117 ? 134.706 143.755 179.823 1.00 118.09 ? 79  THR   N CB  1 
ATOM   505  O OG1 . THR   A 1 117 ? 133.662 142.830 180.153 1.00 118.36 ? 79  THR   N OG1 1 
ATOM   506  C CG2 . THR   A 1 117 ? 134.090 145.049 179.322 1.00 117.37 ? 79  THR   N CG2 1 
ATOM   507  N N   . VAL   A 1 118 ? 137.299 142.022 180.093 1.00 118.24 ? 80  VAL   N N   1 
ATOM   508  C CA  . VAL   A 1 118 ? 137.935 140.930 180.818 1.00 120.20 ? 80  VAL   N CA  1 
ATOM   509  C C   . VAL   A 1 118 ? 138.009 141.315 182.290 1.00 120.94 ? 80  VAL   N C   1 
ATOM   510  O O   . VAL   A 1 118 ? 138.340 142.457 182.628 1.00 121.08 ? 80  VAL   N O   1 
ATOM   511  C CB  . VAL   A 1 118 ? 139.333 140.596 180.249 1.00 119.81 ? 80  VAL   N CB  1 
ATOM   512  C CG1 . VAL   A 1 118 ? 140.277 141.782 180.370 1.00 118.02 ? 80  VAL   N CG1 1 
ATOM   513  C CG2 . VAL   A 1 118 ? 139.916 139.377 180.944 1.00 120.54 ? 80  VAL   N CG2 1 
ATOM   514  N N   . TYR   A 1 119 ? 137.667 140.373 183.163 1.00 130.01 ? 81  TYR   N N   1 
ATOM   515  C CA  . TYR   A 1 119 ? 137.602 140.615 184.598 1.00 129.27 ? 81  TYR   N CA  1 
ATOM   516  C C   . TYR   A 1 119 ? 138.594 139.713 185.315 1.00 128.95 ? 81  TYR   N C   1 
ATOM   517  O O   . TYR   A 1 119 ? 138.608 138.498 185.095 1.00 129.24 ? 81  TYR   N O   1 
ATOM   518  C CB  . TYR   A 1 119 ? 136.189 140.372 185.135 1.00 127.66 ? 81  TYR   N CB  1 
ATOM   519  C CG  . TYR   A 1 119 ? 135.136 141.260 184.514 1.00 128.76 ? 81  TYR   N CG  1 
ATOM   520  C CD1 . TYR   A 1 119 ? 135.146 142.632 184.725 1.00 129.10 ? 81  TYR   N CD1 1 
ATOM   521  C CD2 . TYR   A 1 119 ? 134.133 140.727 183.717 1.00 129.68 ? 81  TYR   N CD2 1 
ATOM   522  C CE1 . TYR   A 1 119 ? 134.185 143.448 184.158 1.00 128.80 ? 81  TYR   N CE1 1 
ATOM   523  C CE2 . TYR   A 1 119 ? 133.168 141.535 183.146 1.00 129.04 ? 81  TYR   N CE2 1 
ATOM   524  C CZ  . TYR   A 1 119 ? 133.199 142.894 183.371 1.00 128.75 ? 81  TYR   N CZ  1 
ATOM   525  O OH  . TYR   A 1 119 ? 132.242 143.703 182.805 1.00 129.52 ? 81  TYR   N OH  1 
ATOM   526  N N   . LEU   A 1 120 ? 139.417 140.309 186.173 1.00 135.01 ? 82  LEU   N N   1 
ATOM   527  C CA  . LEU   A 1 120 ? 140.372 139.580 186.995 1.00 136.67 ? 82  LEU   N CA  1 
ATOM   528  C C   . LEU   A 1 120 ? 139.997 139.759 188.458 1.00 139.86 ? 82  LEU   N C   1 
ATOM   529  O O   . LEU   A 1 120 ? 139.753 140.884 188.905 1.00 140.05 ? 82  LEU   N O   1 
ATOM   530  C CB  . LEU   A 1 120 ? 141.802 140.067 186.749 1.00 136.59 ? 82  LEU   N CB  1 
ATOM   531  C CG  . LEU   A 1 120 ? 142.890 139.410 187.601 1.00 138.53 ? 82  LEU   N CG  1 
ATOM   532  C CD1 . LEU   A 1 120 ? 143.028 137.936 187.253 1.00 137.78 ? 82  LEU   N CD1 1 
ATOM   533  C CD2 . LEU   A 1 120 ? 144.219 140.132 187.438 1.00 137.50 ? 82  LEU   N CD2 1 
ATOM   534  N N   . GLN   A 1 121 ? 139.949 138.655 189.196 1.00 148.82 ? 83  GLN   N N   1 
ATOM   535  C CA  . GLN   A 1 121 ? 139.589 138.674 190.607 1.00 147.52 ? 83  GLN   N CA  1 
ATOM   536  C C   . GLN   A 1 121 ? 140.841 138.514 191.457 1.00 147.11 ? 83  GLN   N C   1 
ATOM   537  O O   . GLN   A 1 121 ? 141.629 137.587 191.245 1.00 146.03 ? 83  GLN   N O   1 
ATOM   538  C CB  . GLN   A 1 121 ? 138.579 137.571 190.926 1.00 148.32 ? 83  GLN   N CB  1 
ATOM   539  C CG  . GLN   A 1 121 ? 137.171 137.876 190.445 1.00 148.98 ? 83  GLN   N CG  1 
ATOM   540  C CD  . GLN   A 1 121 ? 136.288 136.646 190.391 1.00 148.91 ? 83  GLN   N CD  1 
ATOM   541  O OE1 . GLN   A 1 121 ? 135.459 136.423 191.272 1.00 148.28 ? 83  GLN   N OE1 1 
ATOM   542  N NE2 . GLN   A 1 121 ? 136.460 135.840 189.349 1.00 148.04 ? 83  GLN   N NE2 1 
ATOM   543  N N   . MET   A 1 122 ? 141.019 139.420 192.413 1.00 162.92 ? 84  MET   N N   1 
ATOM   544  C CA  . MET   A 1 122 ? 142.193 139.443 193.275 1.00 164.68 ? 84  MET   N CA  1 
ATOM   545  C C   . MET   A 1 122 ? 141.824 138.835 194.622 1.00 164.90 ? 84  MET   N C   1 
ATOM   546  O O   . MET   A 1 122 ? 140.907 139.319 195.294 1.00 164.92 ? 84  MET   N O   1 
ATOM   547  C CB  . MET   A 1 122 ? 142.700 140.875 193.452 1.00 165.06 ? 84  MET   N CB  1 
ATOM   548  C CG  . MET   A 1 122 ? 143.033 141.586 192.147 1.00 164.94 ? 84  MET   N CG  1 
ATOM   549  S SD  . MET   A 1 122 ? 144.504 142.623 192.243 1.00 165.66 ? 84  MET   N SD  1 
ATOM   550  C CE  . MET   A 1 122 ? 145.799 141.398 192.105 1.00 163.45 ? 84  MET   N CE  1 
ATOM   551  N N   . SER   A 1 123 ? 142.531 137.777 195.014 1.00 166.64 ? 85  SER   N N   1 
ATOM   552  C CA  . SER   A 1 123 ? 142.275 137.111 196.282 1.00 166.02 ? 85  SER   N CA  1 
ATOM   553  C C   . SER   A 1 123 ? 143.595 136.750 196.944 1.00 166.77 ? 85  SER   N C   1 
ATOM   554  O O   . SER   A 1 123 ? 144.573 136.412 196.271 1.00 166.32 ? 85  SER   N O   1 
ATOM   555  C CB  . SER   A 1 123 ? 141.419 135.850 196.098 1.00 165.63 ? 85  SER   N CB  1 
ATOM   556  O OG  . SER   A 1 123 ? 142.071 134.908 195.266 1.00 166.00 ? 85  SER   N OG  1 
ATOM   557  N N   . SER   A 1 124 ? 143.606 136.817 198.275 1.00 172.41 ? 86  SER   N N   1 
ATOM   558  C CA  . SER   A 1 124 ? 144.785 136.518 199.086 1.00 172.44 ? 86  SER   N CA  1 
ATOM   559  C C   . SER   A 1 124 ? 145.980 137.359 198.640 1.00 171.97 ? 86  SER   N C   1 
ATOM   560  O O   . SER   A 1 124 ? 147.026 136.849 198.238 1.00 171.56 ? 86  SER   N O   1 
ATOM   561  C CB  . SER   A 1 124 ? 145.113 135.023 199.045 1.00 172.32 ? 86  SER   N CB  1 
ATOM   562  O OG  . SER   A 1 124 ? 146.320 134.748 199.736 1.00 171.53 ? 86  SER   N OG  1 
ATOM   563  N N   . LEU   A 1 125 ? 145.797 138.675 198.715 1.00 174.63 ? 87  LEU   N N   1 
ATOM   564  C CA  . LEU   A 1 125 ? 146.826 139.601 198.263 1.00 174.76 ? 87  LEU   N CA  1 
ATOM   565  C C   . LEU   A 1 125 ? 148.090 139.455 199.100 1.00 174.74 ? 87  LEU   N C   1 
ATOM   566  O O   . LEU   A 1 125 ? 148.034 139.231 200.312 1.00 174.93 ? 87  LEU   N O   1 
ATOM   567  C CB  . LEU   A 1 125 ? 146.307 141.037 198.330 1.00 174.95 ? 87  LEU   N CB  1 
ATOM   568  C CG  . LEU   A 1 125 ? 145.269 141.402 197.267 1.00 175.12 ? 87  LEU   N CG  1 
ATOM   569  C CD1 . LEU   A 1 125 ? 144.376 142.530 197.752 1.00 174.57 ? 87  LEU   N CD1 1 
ATOM   570  C CD2 . LEU   A 1 125 ? 145.949 141.776 195.959 1.00 174.48 ? 87  LEU   N CD2 1 
ATOM   571  N N   . LYS   A 1 126 ? 149.233 139.585 198.443 1.00 174.29 ? 88  LYS   N N   1 
ATOM   572  C CA  . LYS   A 1 126 ? 150.541 139.415 199.051 1.00 173.92 ? 88  LYS   N CA  1 
ATOM   573  C C   . LYS   A 1 126 ? 151.380 140.656 198.797 1.00 174.96 ? 88  LYS   N C   1 
ATOM   574  O O   . LYS   A 1 126 ? 151.131 141.398 197.840 1.00 174.48 ? 88  LYS   N O   1 
ATOM   575  C CB  . LYS   A 1 126 ? 151.253 138.175 198.489 1.00 173.01 ? 88  LYS   N CB  1 
ATOM   576  N N   . PRO   A 1 127 ? 152.380 140.918 199.645 1.00 178.15 ? 89  PRO   N N   1 
ATOM   577  C CA  . PRO   A 1 127 ? 153.237 142.094 199.418 1.00 177.58 ? 89  PRO   N CA  1 
ATOM   578  C C   . PRO   A 1 127 ? 153.956 142.069 198.082 1.00 177.21 ? 89  PRO   N C   1 
ATOM   579  O O   . PRO   A 1 127 ? 154.284 143.135 197.545 1.00 177.47 ? 89  PRO   N O   1 
ATOM   580  C CB  . PRO   A 1 127 ? 154.225 142.039 200.592 1.00 176.20 ? 89  PRO   N CB  1 
ATOM   581  C CG  . PRO   A 1 127 ? 153.520 141.252 201.645 1.00 176.66 ? 89  PRO   N CG  1 
ATOM   582  C CD  . PRO   A 1 127 ? 152.700 140.236 200.911 1.00 177.01 ? 89  PRO   N CD  1 
ATOM   583  N N   . GLU   A 1 128 ? 154.217 140.884 197.527 1.00 176.06 ? 90  GLU   N N   1 
ATOM   584  C CA  . GLU   A 1 128 ? 154.857 140.799 196.220 1.00 175.83 ? 90  GLU   N CA  1 
ATOM   585  C C   . GLU   A 1 128 ? 153.909 141.165 195.086 1.00 175.79 ? 90  GLU   N C   1 
ATOM   586  O O   . GLU   A 1 128 ? 154.372 141.450 193.977 1.00 175.56 ? 90  GLU   N O   1 
ATOM   587  C CB  . GLU   A 1 128 ? 155.412 139.391 195.997 1.00 175.95 ? 90  GLU   N CB  1 
ATOM   588  C CG  . GLU   A 1 128 ? 156.428 138.947 197.037 1.00 175.75 ? 90  GLU   N CG  1 
ATOM   589  C CD  . GLU   A 1 128 ? 155.785 138.235 198.211 1.00 175.81 ? 90  GLU   N CD  1 
ATOM   590  O OE1 . GLU   A 1 128 ? 154.570 137.957 198.146 1.00 175.92 ? 90  GLU   N OE1 1 
ATOM   591  O OE2 . GLU   A 1 128 ? 156.495 137.954 199.199 1.00 175.89 ? 90  GLU   N OE2 1 
ATOM   592  N N   . ASP   A 1 129 ? 152.599 141.165 195.336 1.00 172.25 ? 91  ASP   N N   1 
ATOM   593  C CA  . ASP   A 1 129 ? 151.621 141.461 194.297 1.00 171.67 ? 91  ASP   N CA  1 
ATOM   594  C C   . ASP   A 1 129 ? 151.409 142.954 194.082 1.00 171.20 ? 91  ASP   N C   1 
ATOM   595  O O   . ASP   A 1 129 ? 150.677 143.330 193.160 1.00 170.28 ? 91  ASP   N O   1 
ATOM   596  C CB  . ASP   A 1 129 ? 150.281 140.801 194.632 1.00 171.21 ? 91  ASP   N CB  1 
ATOM   597  C CG  . ASP   A 1 129 ? 150.412 139.312 194.882 1.00 171.63 ? 91  ASP   N CG  1 
ATOM   598  O OD1 . ASP   A 1 129 ? 151.342 138.694 194.324 1.00 172.19 ? 91  ASP   N OD1 1 
ATOM   599  O OD2 . ASP   A 1 129 ? 149.583 138.759 195.636 1.00 171.86 ? 91  ASP   N OD2 1 
ATOM   600  N N   . THR   A 1 130 ? 152.020 143.806 194.900 1.00 171.35 ? 92  THR   N N   1 
ATOM   601  C CA  . THR   A 1 130 ? 151.876 145.253 194.760 1.00 171.31 ? 92  THR   N CA  1 
ATOM   602  C C   . THR   A 1 130 ? 152.661 145.706 193.536 1.00 171.79 ? 92  THR   N C   1 
ATOM   603  O O   . THR   A 1 130 ? 153.885 145.844 193.582 1.00 172.15 ? 92  THR   N O   1 
ATOM   604  C CB  . THR   A 1 130 ? 152.359 145.961 196.021 1.00 170.30 ? 92  THR   N CB  1 
ATOM   605  O OG1 . THR   A 1 130 ? 151.508 145.613 197.121 1.00 169.61 ? 92  THR   N OG1 1 
ATOM   606  C CG2 . THR   A 1 130 ? 152.333 147.471 195.831 1.00 170.30 ? 92  THR   N CG2 1 
ATOM   607  N N   . ALA   A 1 131 ? 151.956 145.934 192.432 1.00 163.93 ? 93  ALA   N N   1 
ATOM   608  C CA  . ALA   A 1 131 ? 152.587 146.335 191.181 1.00 163.32 ? 93  ALA   N CA  1 
ATOM   609  C C   . ALA   A 1 131 ? 151.520 146.930 190.270 1.00 162.55 ? 93  ALA   N C   1 
ATOM   610  O O   . ALA   A 1 131 ? 150.330 146.932 190.593 1.00 162.31 ? 93  ALA   N O   1 
ATOM   611  C CB  . ALA   A 1 131 ? 153.298 145.153 190.516 1.00 162.00 ? 93  ALA   N CB  1 
ATOM   612  N N   . VAL   A 1 132 ? 151.961 147.435 189.121 1.00 152.91 ? 94  VAL   N N   1 
ATOM   613  C CA  . VAL   A 1 132 ? 151.078 148.032 188.126 1.00 152.89 ? 94  VAL   N CA  1 
ATOM   614  C C   . VAL   A 1 132 ? 150.706 146.964 187.108 1.00 152.25 ? 94  VAL   N C   1 
ATOM   615  O O   . VAL   A 1 132 ? 151.584 146.288 186.557 1.00 151.19 ? 94  VAL   N O   1 
ATOM   616  C CB  . VAL   A 1 132 ? 151.742 149.239 187.441 1.00 152.45 ? 94  VAL   N CB  1 
ATOM   617  C CG1 . VAL   A 1 132 ? 150.746 149.950 186.537 1.00 151.93 ? 94  VAL   N CG1 1 
ATOM   618  C CG2 . VAL   A 1 132 ? 152.305 150.194 188.483 1.00 152.69 ? 94  VAL   N CG2 1 
ATOM   619  N N   . TYR   A 1 133 ? 149.410 146.813 186.857 1.00 148.72 ? 95  TYR   N N   1 
ATOM   620  C CA  . TYR   A 1 133 ? 148.891 145.771 185.983 1.00 147.83 ? 95  TYR   N CA  1 
ATOM   621  C C   . TYR   A 1 133 ? 148.412 146.390 184.678 1.00 146.22 ? 95  TYR   N C   1 
ATOM   622  O O   . TYR   A 1 133 ? 147.676 147.382 184.689 1.00 146.90 ? 95  TYR   N O   1 
ATOM   623  C CB  . TYR   A 1 133 ? 147.751 145.010 186.663 1.00 148.78 ? 95  TYR   N CB  1 
ATOM   624  C CG  . TYR   A 1 133 ? 148.180 144.245 187.896 1.00 150.16 ? 95  TYR   N CG  1 
ATOM   625  C CD1 . TYR   A 1 133 ? 148.356 144.891 189.113 1.00 149.55 ? 95  TYR   N CD1 1 
ATOM   626  C CD2 . TYR   A 1 133 ? 148.412 142.877 187.843 1.00 149.46 ? 95  TYR   N CD2 1 
ATOM   627  C CE1 . TYR   A 1 133 ? 148.750 144.198 190.241 1.00 149.11 ? 95  TYR   N CE1 1 
ATOM   628  C CE2 . TYR   A 1 133 ? 148.806 142.175 188.967 1.00 149.47 ? 95  TYR   N CE2 1 
ATOM   629  C CZ  . TYR   A 1 133 ? 148.973 142.841 190.162 1.00 149.97 ? 95  TYR   N CZ  1 
ATOM   630  O OH  . TYR   A 1 133 ? 149.365 142.148 191.284 1.00 150.85 ? 95  TYR   N OH  1 
ATOM   631  N N   . TYR   A 1 134 ? 148.829 145.803 183.560 1.00 135.13 ? 96  TYR   N N   1 
ATOM   632  C CA  . TYR   A 1 134 ? 148.485 146.289 182.231 1.00 135.67 ? 96  TYR   N CA  1 
ATOM   633  C C   . TYR   A 1 134 ? 147.607 145.265 181.528 1.00 133.51 ? 96  TYR   N C   1 
ATOM   634  O O   . TYR   A 1 134 ? 147.918 144.070 181.529 1.00 134.89 ? 96  TYR   N O   1 
ATOM   635  C CB  . TYR   A 1 134 ? 149.743 146.560 181.405 1.00 135.33 ? 96  TYR   N CB  1 
ATOM   636  C CG  . TYR   A 1 134 ? 150.617 147.659 181.962 1.00 137.34 ? 96  TYR   N CG  1 
ATOM   637  C CD1 . TYR   A 1 134 ? 151.510 147.407 182.993 1.00 137.77 ? 96  TYR   N CD1 1 
ATOM   638  C CD2 . TYR   A 1 134 ? 150.549 148.949 181.454 1.00 136.97 ? 96  TYR   N CD2 1 
ATOM   639  C CE1 . TYR   A 1 134 ? 152.310 148.409 183.506 1.00 137.65 ? 96  TYR   N CE1 1 
ATOM   640  C CE2 . TYR   A 1 134 ? 151.345 149.958 181.960 1.00 137.08 ? 96  TYR   N CE2 1 
ATOM   641  C CZ  . TYR   A 1 134 ? 152.223 149.682 182.986 1.00 137.36 ? 96  TYR   N CZ  1 
ATOM   642  O OH  . TYR   A 1 134 ? 153.019 150.684 183.492 1.00 136.95 ? 96  TYR   N OH  1 
ATOM   643  N N   . CYS   A 1 135 ? 146.518 145.734 180.928 1.00 113.55 ? 97  CYS   N N   1 
ATOM   644  C CA  . CYS   A 1 135 ? 145.604 144.864 180.205 1.00 111.01 ? 97  CYS   N CA  1 
ATOM   645  C C   . CYS   A 1 135 ? 145.997 144.814 178.736 1.00 111.81 ? 97  CYS   N C   1 
ATOM   646  O O   . CYS   A 1 135 ? 146.192 145.856 178.102 1.00 116.56 ? 97  CYS   N O   1 
ATOM   647  C CB  . CYS   A 1 135 ? 144.162 145.350 180.350 1.00 115.01 ? 97  CYS   N CB  1 
ATOM   648  S SG  . CYS   A 1 135 ? 142.990 144.527 179.249 1.00 121.50 ? 97  CYS   N SG  1 
ATOM   649  N N   . ASN   A 1 136 ? 146.112 143.604 178.201 1.00 96.85  ? 98  ASN   N N   1 
ATOM   650  C CA  . ASN   A 1 136 ? 146.469 143.384 176.810 1.00 95.62  ? 98  ASN   N CA  1 
ATOM   651  C C   . ASN   A 1 136 ? 145.304 142.729 176.082 1.00 96.05  ? 98  ASN   N C   1 
ATOM   652  O O   . ASN   A 1 136 ? 144.571 141.916 176.651 1.00 97.56  ? 98  ASN   N O   1 
ATOM   653  C CB  . ASN   A 1 136 ? 147.724 142.509 176.693 1.00 98.87  ? 98  ASN   N CB  1 
ATOM   654  C CG  . ASN   A 1 136 ? 148.249 142.419 175.272 1.00 97.68  ? 98  ASN   N CG  1 
ATOM   655  O OD1 . ASN   A 1 136 ? 147.543 142.722 174.313 1.00 95.80  ? 98  ASN   N OD1 1 
ATOM   656  N ND2 . ASN   A 1 136 ? 149.500 142.000 175.133 1.00 96.91  ? 98  ASN   N ND2 1 
ATOM   657  N N   . ALA   A 1 137 ? 145.141 143.095 174.813 1.00 86.20  ? 99  ALA   N N   1 
ATOM   658  C CA  . ALA   A 1 137 ? 144.082 142.539 173.987 1.00 87.03  ? 99  ALA   N CA  1 
ATOM   659  C C   . ALA   A 1 137 ? 144.568 142.447 172.551 1.00 86.70  ? 99  ALA   N C   1 
ATOM   660  O O   . ALA   A 1 137 ? 145.187 143.382 172.038 1.00 92.49  ? 99  ALA   N O   1 
ATOM   661  C CB  . ALA   A 1 137 ? 142.809 143.387 174.061 1.00 86.87  ? 99  ALA   N CB  1 
ATOM   662  N N   . GLU   A 1 138 ? 144.289 141.316 171.912 1.00 80.98  ? 100 GLU   N N   1 
ATOM   663  C CA  . GLU   A 1 138 ? 144.594 141.105 170.504 1.00 79.15  ? 100 GLU   N CA  1 
ATOM   664  C C   . GLU   A 1 138 ? 143.293 141.192 169.720 1.00 79.73  ? 100 GLU   N C   1 
ATOM   665  O O   . GLU   A 1 138 ? 142.349 140.446 169.995 1.00 80.61  ? 100 GLU   N O   1 
ATOM   666  C CB  . GLU   A 1 138 ? 145.274 139.754 170.285 1.00 80.96  ? 100 GLU   N CB  1 
ATOM   667  C CG  . GLU   A 1 138 ? 146.688 139.682 170.833 1.00 84.42  ? 100 GLU   N CG  1 
ATOM   668  C CD  . GLU   A 1 138 ? 147.242 138.274 170.832 1.00 88.15  ? 100 GLU   N CD  1 
ATOM   669  O OE1 . GLU   A 1 138 ? 146.796 137.460 169.999 1.00 89.09  ? 100 GLU   N OE1 1 
ATOM   670  O OE2 . GLU   A 1 138 ? 148.125 137.980 171.664 1.00 85.89  ? 100 GLU   N OE2 1 
ATOM   671  N N   . TYR   A 1 139 ? 143.247 142.097 168.748 1.00 77.69  ? 101 TYR   N N   1 
ATOM   672  C CA  . TYR   A 1 139 ? 142.024 142.409 168.026 1.00 75.62  ? 101 TYR   N CA  1 
ATOM   673  C C   . TYR   A 1 139 ? 142.297 142.394 166.528 1.00 75.39  ? 101 TYR   N C   1 
ATOM   674  O O   . TYR   A 1 139 ? 143.394 142.063 166.072 1.00 82.45  ? 101 TYR   N O   1 
ATOM   675  C CB  . TYR   A 1 139 ? 141.461 143.767 168.466 1.00 81.14  ? 101 TYR   N CB  1 
ATOM   676  C CG  . TYR   A 1 139 ? 142.381 144.934 168.187 1.00 80.39  ? 101 TYR   N CG  1 
ATOM   677  C CD1 . TYR   A 1 139 ? 142.284 145.654 167.005 1.00 80.82  ? 101 TYR   N CD1 1 
ATOM   678  C CD2 . TYR   A 1 139 ? 143.355 145.307 169.101 1.00 80.21  ? 101 TYR   N CD2 1 
ATOM   679  C CE1 . TYR   A 1 139 ? 143.124 146.717 166.746 1.00 79.86  ? 101 TYR   N CE1 1 
ATOM   680  C CE2 . TYR   A 1 139 ? 144.203 146.365 168.849 1.00 82.46  ? 101 TYR   N CE2 1 
ATOM   681  C CZ  . TYR   A 1 139 ? 144.081 147.068 167.671 1.00 83.89  ? 101 TYR   N CZ  1 
ATOM   682  O OH  . TYR   A 1 139 ? 144.923 148.126 167.417 1.00 85.61  ? 101 TYR   N OH  1 
ATOM   683  N N   . ARG   A 1 140 ? 141.275 142.762 165.761 1.00 66.16  ? 102 ARG   N N   1 
ATOM   684  C CA  . ARG   A 1 140 ? 141.382 142.851 164.312 1.00 65.22  ? 102 ARG   N CA  1 
ATOM   685  C C   . ARG   A 1 140 ? 140.245 143.732 163.821 1.00 72.23  ? 102 ARG   N C   1 
ATOM   686  O O   . ARG   A 1 140 ? 139.100 143.548 164.241 1.00 77.06  ? 102 ARG   N O   1 
ATOM   687  C CB  . ARG   A 1 140 ? 141.317 141.464 163.667 1.00 66.28  ? 102 ARG   N CB  1 
ATOM   688  C CG  . ARG   A 1 140 ? 141.644 141.449 162.191 1.00 68.54  ? 102 ARG   N CG  1 
ATOM   689  C CD  . ARG   A 1 140 ? 141.792 140.031 161.669 1.00 63.53  ? 102 ARG   N CD  1 
ATOM   690  N NE  . ARG   A 1 140 ? 143.151 139.532 161.831 1.00 66.95  ? 102 ARG   N NE  1 
ATOM   691  C CZ  . ARG   A 1 140 ? 143.455 138.291 162.183 1.00 70.88  ? 102 ARG   N CZ  1 
ATOM   692  N NH1 . ARG   A 1 140 ? 142.517 137.387 162.407 1.00 71.86  ? 102 ARG   N NH1 1 
ATOM   693  N NH2 . ARG   A 1 140 ? 144.733 137.947 162.310 1.00 69.38  ? 102 ARG   N NH2 1 
ATOM   694  N N   . THR   A 1 141 ? 140.560 144.689 162.949 1.00 70.61  ? 103 THR   N N   1 
ATOM   695  C CA  . THR   A 1 141 ? 139.574 145.664 162.503 1.00 68.49  ? 103 THR   N CA  1 
ATOM   696  C C   . THR   A 1 141 ? 138.794 145.226 161.270 1.00 67.85  ? 103 THR   N C   1 
ATOM   697  O O   . THR   A 1 141 ? 137.836 145.908 160.893 1.00 71.02  ? 103 THR   N O   1 
ATOM   698  C CB  . THR   A 1 141 ? 140.251 147.007 162.215 1.00 71.97  ? 103 THR   N CB  1 
ATOM   699  O OG1 . THR   A 1 141 ? 141.154 146.861 161.114 1.00 74.73  ? 103 THR   N OG1 1 
ATOM   700  C CG2 . THR   A 1 141 ? 141.021 147.482 163.433 1.00 74.22  ? 103 THR   N CG2 1 
ATOM   701  N N   . GLY   A 1 142 ? 139.167 144.119 160.639 1.00 66.99  ? 104 GLY   N N   1 
ATOM   702  C CA  . GLY   A 1 142 ? 138.462 143.665 159.453 1.00 63.57  ? 104 GLY   N CA  1 
ATOM   703  C C   . GLY   A 1 142 ? 138.939 142.290 159.051 1.00 67.63  ? 104 GLY   N C   1 
ATOM   704  O O   . GLY   A 1 142 ? 139.979 141.810 159.509 1.00 74.03  ? 104 GLY   N O   1 
ATOM   705  N N   . ILE   A 1 143 ? 138.158 141.660 158.171 1.00 61.01  ? 105 ILE   N N   1 
ATOM   706  C CA  . ILE   A 1 143 ? 138.475 140.302 157.737 1.00 59.31  ? 105 ILE   N CA  1 
ATOM   707  C C   . ILE   A 1 143 ? 139.819 140.267 157.022 1.00 61.10  ? 105 ILE   N C   1 
ATOM   708  O O   . ILE   A 1 143 ? 140.638 139.369 157.252 1.00 68.90  ? 105 ILE   N O   1 
ATOM   709  C CB  . ILE   A 1 143 ? 137.345 139.745 156.851 1.00 55.59  ? 105 ILE   N CB  1 
ATOM   710  C CG1 . ILE   A 1 143 ? 136.155 139.325 157.709 1.00 63.47  ? 105 ILE   N CG1 1 
ATOM   711  C CG2 . ILE   A 1 143 ? 137.833 138.565 156.039 1.00 63.07  ? 105 ILE   N CG2 1 
ATOM   712  C CD1 . ILE   A 1 143 ? 135.049 138.657 156.928 1.00 65.78  ? 105 ILE   N CD1 1 
ATOM   713  N N   . TRP   A 1 144 ? 140.074 141.244 156.159 1.00 55.55  ? 106 TRP   N N   1 
ATOM   714  C CA  . TRP   A 1 144 ? 141.297 141.281 155.370 1.00 57.39  ? 106 TRP   N CA  1 
ATOM   715  C C   . TRP   A 1 144 ? 142.456 141.949 156.097 1.00 60.46  ? 106 TRP   N C   1 
ATOM   716  O O   . TRP   A 1 144 ? 143.540 142.072 155.519 1.00 64.57  ? 106 TRP   N O   1 
ATOM   717  C CB  . TRP   A 1 144 ? 141.037 141.997 154.043 1.00 56.06  ? 106 TRP   N CB  1 
ATOM   718  C CG  . TRP   A 1 144 ? 139.728 141.624 153.434 1.00 59.31  ? 106 TRP   N CG  1 
ATOM   719  C CD1 . TRP   A 1 144 ? 138.617 142.406 153.338 1.00 59.58  ? 106 TRP   N CD1 1 
ATOM   720  C CD2 . TRP   A 1 144 ? 139.386 140.366 152.846 1.00 59.02  ? 106 TRP   N CD2 1 
ATOM   721  N NE1 . TRP   A 1 144 ? 137.604 141.715 152.722 1.00 58.43  ? 106 TRP   N NE1 1 
ATOM   722  C CE2 . TRP   A 1 144 ? 138.052 140.459 152.410 1.00 58.75  ? 106 TRP   N CE2 1 
ATOM   723  C CE3 . TRP   A 1 144 ? 140.079 139.170 152.643 1.00 53.32  ? 106 TRP   N CE3 1 
ATOM   724  C CZ2 . TRP   A 1 144 ? 137.397 139.403 151.785 1.00 56.98  ? 106 TRP   N CZ2 1 
ATOM   725  C CZ3 . TRP   A 1 144 ? 139.429 138.125 152.023 1.00 55.29  ? 106 TRP   N CZ3 1 
ATOM   726  C CH2 . TRP   A 1 144 ? 138.102 138.247 151.602 1.00 57.03  ? 106 TRP   N CH2 1 
ATOM   727  N N   . GLU   A 1 145 ? 142.260 142.377 157.338 1.00 64.53  ? 107 GLU   N N   1 
ATOM   728  C CA  . GLU   A 1 145 ? 143.312 143.036 158.093 1.00 65.69  ? 107 GLU   N CA  1 
ATOM   729  C C   . GLU   A 1 145 ? 144.147 142.017 158.861 1.00 68.00  ? 107 GLU   N C   1 
ATOM   730  O O   . GLU   A 1 145 ? 143.719 140.890 159.119 1.00 69.69  ? 107 GLU   N O   1 
ATOM   731  C CB  . GLU   A 1 145 ? 142.718 144.062 159.058 1.00 66.77  ? 107 GLU   N CB  1 
ATOM   732  C CG  . GLU   A 1 145 ? 141.824 145.093 158.392 1.00 73.16  ? 107 GLU   N CG  1 
ATOM   733  C CD  . GLU   A 1 145 ? 142.562 145.934 157.370 1.00 77.47  ? 107 GLU   N CD  1 
ATOM   734  O OE1 . GLU   A 1 145 ? 143.740 146.270 157.613 1.00 79.40  ? 107 GLU   N OE1 1 
ATOM   735  O OE2 . GLU   A 1 145 ? 141.964 146.259 156.322 1.00 73.66  ? 107 GLU   N OE2 1 
ATOM   736  N N   . GLU   A 1 146 ? 145.356 142.433 159.224 1.00 74.14  ? 108 GLU   N N   1 
ATOM   737  C CA  . GLU   A 1 146 ? 146.264 141.588 159.978 1.00 76.19  ? 108 GLU   N CA  1 
ATOM   738  C C   . GLU   A 1 146 ? 145.912 141.616 161.464 1.00 80.91  ? 108 GLU   N C   1 
ATOM   739  O O   . GLU   A 1 146 ? 145.065 142.389 161.918 1.00 87.40  ? 108 GLU   N O   1 
ATOM   740  C CB  . GLU   A 1 146 ? 147.707 142.037 159.766 1.00 76.37  ? 108 GLU   N CB  1 
ATOM   741  C CG  . GLU   A 1 146 ? 148.049 143.340 160.463 1.00 79.91  ? 108 GLU   N CG  1 
ATOM   742  C CD  . GLU   A 1 146 ? 149.540 143.603 160.510 1.00 84.23  ? 108 GLU   N CD  1 
ATOM   743  O OE1 . GLU   A 1 146 ? 150.255 142.848 161.200 1.00 83.57  ? 108 GLU   N OE1 1 
ATOM   744  O OE2 . GLU   A 1 146 ? 149.995 144.567 159.859 1.00 84.30  ? 108 GLU   N OE2 1 
ATOM   745  N N   . LEU   A 1 147 ? 146.571 140.748 162.226 1.00 75.47  ? 109 LEU   N N   1 
ATOM   746  C CA  . LEU   A 1 147 ? 146.380 140.728 163.669 1.00 74.02  ? 109 LEU   N CA  1 
ATOM   747  C C   . LEU   A 1 147 ? 147.049 141.938 164.306 1.00 76.55  ? 109 LEU   N C   1 
ATOM   748  O O   . LEU   A 1 147 ? 148.179 142.294 163.963 1.00 84.98  ? 109 LEU   N O   1 
ATOM   749  C CB  . LEU   A 1 147 ? 146.949 139.441 164.264 1.00 76.06  ? 109 LEU   N CB  1 
ATOM   750  C CG  . LEU   A 1 147 ? 146.569 139.125 165.710 1.00 73.17  ? 109 LEU   N CG  1 
ATOM   751  C CD1 . LEU   A 1 147 ? 145.262 138.363 165.756 1.00 72.53  ? 109 LEU   N CD1 1 
ATOM   752  C CD2 . LEU   A 1 147 ? 147.671 138.339 166.394 1.00 72.58  ? 109 LEU   N CD2 1 
ATOM   753  N N   . LEU   A 1 148 ? 146.350 142.568 165.243 1.00 75.24  ? 110 LEU   N N   1 
ATOM   754  C CA  . LEU   A 1 148 ? 146.851 143.753 165.919 1.00 78.74  ? 110 LEU   N CA  1 
ATOM   755  C C   . LEU   A 1 148 ? 146.941 143.509 167.419 1.00 80.00  ? 110 LEU   N C   1 
ATOM   756  O O   . LEU   A 1 148 ? 146.242 142.661 167.979 1.00 80.80  ? 110 LEU   N O   1 
ATOM   757  C CB  . LEU   A 1 148 ? 145.966 144.977 165.646 1.00 80.70  ? 110 LEU   N CB  1 
ATOM   758  C CG  . LEU   A 1 148 ? 146.291 145.857 164.436 1.00 80.64  ? 110 LEU   N CG  1 
ATOM   759  C CD1 . LEU   A 1 148 ? 147.685 146.454 164.568 1.00 80.84  ? 110 LEU   N CD1 1 
ATOM   760  C CD2 . LEU   A 1 148 ? 146.146 145.105 163.127 1.00 77.22  ? 110 LEU   N CD2 1 
ATOM   761  N N   . ASP   A 1 149 ? 147.820 144.270 168.061 1.00 89.82  ? 111 ASP   N N   1 
ATOM   762  C CA  . ASP   A 1 149 ? 148.079 144.164 169.488 1.00 88.79  ? 111 ASP   N CA  1 
ATOM   763  C C   . ASP   A 1 149 ? 147.796 145.501 170.158 1.00 88.67  ? 111 ASP   N C   1 
ATOM   764  O O   . ASP   A 1 149 ? 148.200 146.554 169.657 1.00 93.27  ? 111 ASP   N O   1 
ATOM   765  C CB  . ASP   A 1 149 ? 149.530 143.742 169.747 1.00 91.91  ? 111 ASP   N CB  1 
ATOM   766  C CG  . ASP   A 1 149 ? 149.712 143.071 171.089 1.00 94.16  ? 111 ASP   N CG  1 
ATOM   767  O OD1 . ASP   A 1 149 ? 148.807 143.188 171.938 1.00 96.55  ? 111 ASP   N OD1 1 
ATOM   768  O OD2 . ASP   A 1 149 ? 150.761 142.426 171.296 1.00 93.62  ? 111 ASP   N OD2 1 
ATOM   769  N N   . GLY   A 1 150 ? 147.101 145.454 171.295 1.00 92.36  ? 112 GLY   N N   1 
ATOM   770  C CA  . GLY   A 1 150 ? 146.778 146.653 172.032 1.00 93.81  ? 112 GLY   N CA  1 
ATOM   771  C C   . GLY   A 1 150 ? 147.217 146.537 173.479 1.00 94.39  ? 112 GLY   N C   1 
ATOM   772  O O   . GLY   A 1 150 ? 147.499 145.451 173.982 1.00 99.37  ? 112 GLY   N O   1 
ATOM   773  N N   . TRP   A 1 151 ? 147.279 147.688 174.143 1.00 102.69 ? 113 TRP   N N   1 
ATOM   774  C CA  . TRP   A 1 151 ? 147.681 147.745 175.540 1.00 104.33 ? 113 TRP   N CA  1 
ATOM   775  C C   . TRP   A 1 151 ? 146.856 148.794 176.268 1.00 105.58 ? 113 TRP   N C   1 
ATOM   776  O O   . TRP   A 1 151 ? 146.390 149.766 175.670 1.00 108.93 ? 113 TRP   N O   1 
ATOM   777  C CB  . TRP   A 1 151 ? 149.174 148.057 175.685 1.00 104.79 ? 113 TRP   N CB  1 
ATOM   778  C CG  . TRP   A 1 151 ? 150.058 146.913 175.304 1.00 105.96 ? 113 TRP   N CG  1 
ATOM   779  C CD1 . TRP   A 1 151 ? 150.534 146.627 174.059 1.00 105.77 ? 113 TRP   N CD1 1 
ATOM   780  C CD2 . TRP   A 1 151 ? 150.570 145.897 176.173 1.00 107.15 ? 113 TRP   N CD2 1 
ATOM   781  N NE1 . TRP   A 1 151 ? 151.312 145.496 174.099 1.00 106.44 ? 113 TRP   N NE1 1 
ATOM   782  C CE2 . TRP   A 1 151 ? 151.350 145.029 175.386 1.00 106.68 ? 113 TRP   N CE2 1 
ATOM   783  C CE3 . TRP   A 1 151 ? 150.446 145.638 177.541 1.00 107.66 ? 113 TRP   N CE3 1 
ATOM   784  C CZ2 . TRP   A 1 151 ? 152.002 143.922 175.920 1.00 106.83 ? 113 TRP   N CZ2 1 
ATOM   785  C CZ3 . TRP   A 1 151 ? 151.094 144.538 178.068 1.00 107.02 ? 113 TRP   N CZ3 1 
ATOM   786  C CH2 . TRP   A 1 151 ? 151.861 143.694 177.260 1.00 107.83 ? 113 TRP   N CH2 1 
ATOM   787  N N   . GLY   A 1 152 ? 146.684 148.586 177.574 1.00 120.09 ? 114 GLY   N N   1 
ATOM   788  C CA  . GLY   A 1 152 ? 145.939 149.507 178.403 1.00 119.80 ? 114 GLY   N CA  1 
ATOM   789  C C   . GLY   A 1 152 ? 146.828 150.554 179.046 1.00 122.68 ? 114 GLY   N C   1 
ATOM   790  O O   . GLY   A 1 152 ? 148.051 150.547 178.917 1.00 123.30 ? 114 GLY   N O   1 
ATOM   791  N N   . GLN   A 1 153 ? 146.180 151.481 179.754 1.00 137.93 ? 115 GLN   N N   1 
ATOM   792  C CA  . GLN   A 1 153 ? 146.913 152.552 180.420 1.00 138.14 ? 115 GLN   N CA  1 
ATOM   793  C C   . GLN   A 1 153 ? 147.770 152.010 181.557 1.00 138.04 ? 115 GLN   N C   1 
ATOM   794  O O   . GLN   A 1 153 ? 148.943 152.379 181.695 1.00 137.82 ? 115 GLN   N O   1 
ATOM   795  C CB  . GLN   A 1 153 ? 145.936 153.607 180.939 1.00 138.32 ? 115 GLN   N CB  1 
ATOM   796  C CG  . GLN   A 1 153 ? 145.116 154.282 179.853 1.00 139.06 ? 115 GLN   N CG  1 
ATOM   797  C CD  . GLN   A 1 153 ? 144.326 155.468 180.372 1.00 140.11 ? 115 GLN   N CD  1 
ATOM   798  O OE1 . GLN   A 1 153 ? 144.289 155.724 181.575 1.00 140.40 ? 115 GLN   N OE1 1 
ATOM   799  N NE2 . GLN   A 1 153 ? 143.689 156.197 179.464 1.00 139.46 ? 115 GLN   N NE2 1 
ATOM   800  N N   . GLY   A 1 154 ? 147.205 151.131 182.378 1.00 144.40 ? 116 GLY   N N   1 
ATOM   801  C CA  . GLY   A 1 154 ? 147.934 150.593 183.527 1.00 145.39 ? 116 GLY   N CA  1 
ATOM   802  C C   . GLY   A 1 154 ? 147.198 150.913 184.814 1.00 146.81 ? 116 GLY   N C   1 
ATOM   803  O O   . GLY   A 1 154 ? 146.790 152.045 185.068 1.00 146.56 ? 116 GLY   N O   1 
ATOM   804  N N   . THR   A 1 155 ? 147.027 149.886 185.643 1.00 153.15 ? 117 THR   N N   1 
ATOM   805  C CA  . THR   A 1 155 ? 146.326 150.001 186.914 1.00 151.74 ? 117 THR   N CA  1 
ATOM   806  C C   . THR   A 1 155 ? 147.277 149.646 188.047 1.00 151.31 ? 117 THR   N C   1 
ATOM   807  O O   . THR   A 1 155 ? 147.905 148.583 188.025 1.00 150.93 ? 117 THR   N O   1 
ATOM   808  C CB  . THR   A 1 155 ? 145.098 149.088 186.951 1.00 151.65 ? 117 THR   N CB  1 
ATOM   809  O OG1 . THR   A 1 155 ? 144.214 149.431 185.877 1.00 150.52 ? 117 THR   N OG1 1 
ATOM   810  C CG2 . THR   A 1 155 ? 144.365 149.234 188.271 1.00 150.62 ? 117 THR   N CG2 1 
ATOM   811  N N   . GLN   A 1 156 ? 147.376 150.533 189.034 1.00 158.71 ? 118 GLN   N N   1 
ATOM   812  C CA  . GLN   A 1 156 ? 148.264 150.349 190.174 1.00 159.06 ? 118 GLN   N CA  1 
ATOM   813  C C   . GLN   A 1 156 ? 147.468 149.843 191.370 1.00 159.43 ? 118 GLN   N C   1 
ATOM   814  O O   . GLN   A 1 156 ? 146.438 150.424 191.727 1.00 158.82 ? 118 GLN   N O   1 
ATOM   815  C CB  . GLN   A 1 156 ? 148.973 151.658 190.525 1.00 158.99 ? 118 GLN   N CB  1 
ATOM   816  C CG  . GLN   A 1 156 ? 149.578 151.684 191.918 1.00 159.50 ? 118 GLN   N CG  1 
ATOM   817  C CD  . GLN   A 1 156 ? 150.700 150.681 192.085 1.00 160.18 ? 118 GLN   N CD  1 
ATOM   818  O OE1 . GLN   A 1 156 ? 150.470 149.530 192.456 1.00 160.72 ? 118 GLN   N OE1 1 
ATOM   819  N NE2 . GLN   A 1 156 ? 151.926 151.114 191.812 1.00 160.22 ? 118 GLN   N NE2 1 
ATOM   820  N N   . VAL   A 1 157 ? 147.948 148.764 191.984 1.00 166.27 ? 119 VAL   N N   1 
ATOM   821  C CA  . VAL   A 1 157 ? 147.301 148.154 193.141 1.00 166.74 ? 119 VAL   N CA  1 
ATOM   822  C C   . VAL   A 1 157 ? 148.333 148.033 194.253 1.00 166.82 ? 119 VAL   N C   1 
ATOM   823  O O   . VAL   A 1 157 ? 149.399 147.439 194.052 1.00 165.76 ? 119 VAL   N O   1 
ATOM   824  C CB  . VAL   A 1 157 ? 146.701 146.778 192.806 1.00 166.81 ? 119 VAL   N CB  1 
ATOM   825  C CG1 . VAL   A 1 157 ? 146.333 146.032 194.080 1.00 166.13 ? 119 VAL   N CG1 1 
ATOM   826  C CG2 . VAL   A 1 157 ? 145.487 146.935 191.903 1.00 166.24 ? 119 VAL   N CG2 1 
ATOM   827  N N   . THR   A 1 158 ? 148.016 148.587 195.422 1.00 173.47 ? 120 THR   N N   1 
ATOM   828  C CA  . THR   A 1 158 ? 148.891 148.537 196.586 1.00 173.38 ? 120 THR   N CA  1 
ATOM   829  C C   . THR   A 1 158 ? 148.182 147.804 197.715 1.00 173.33 ? 120 THR   N C   1 
ATOM   830  O O   . THR   A 1 158 ? 147.028 148.112 198.032 1.00 172.24 ? 120 THR   N O   1 
ATOM   831  C CB  . THR   A 1 158 ? 149.293 149.943 197.041 1.00 172.94 ? 120 THR   N CB  1 
ATOM   832  O OG1 . THR   A 1 158 ? 148.117 150.706 197.340 1.00 172.59 ? 120 THR   N OG1 1 
ATOM   833  C CG2 . THR   A 1 158 ? 150.086 150.649 195.952 1.00 172.14 ? 120 THR   N CG2 1 
ATOM   834  N N   . VAL   A 1 159 ? 148.874 146.845 198.321 1.00 177.78 ? 121 VAL   N N   1 
ATOM   835  C CA  . VAL   A 1 159 ? 148.313 146.037 199.398 1.00 177.39 ? 121 VAL   N CA  1 
ATOM   836  C C   . VAL   A 1 159 ? 148.679 146.677 200.730 1.00 177.14 ? 121 VAL   N C   1 
ATOM   837  O O   . VAL   A 1 159 ? 149.861 146.888 201.024 1.00 177.04 ? 121 VAL   N O   1 
ATOM   838  C CB  . VAL   A 1 159 ? 148.816 144.588 199.326 1.00 176.18 ? 121 VAL   N CB  1 
ATOM   839  N N   . SER   A 1 160 ? 147.666 146.987 201.534 1.00 175.45 ? 122 SER   N N   1 
ATOM   840  C CA  . SER   A 1 160 ? 147.900 147.588 202.838 1.00 175.41 ? 122 SER   N CA  1 
ATOM   841  C C   . SER   A 1 160 ? 148.548 146.585 203.787 1.00 176.51 ? 122 SER   N C   1 
ATOM   842  O O   . SER   A 1 160 ? 148.346 145.372 203.682 1.00 175.76 ? 122 SER   N O   1 
ATOM   843  C CB  . SER   A 1 160 ? 146.588 148.098 203.434 1.00 174.53 ? 122 SER   N CB  1 
ATOM   844  N N   . SER   A 1 161 ? 149.337 147.107 204.720 1.00 175.24 ? 123 SER   N N   1 
ATOM   845  C CA  . SER   A 1 161 ? 150.020 146.274 205.703 1.00 173.62 ? 123 SER   N CA  1 
ATOM   846  C C   . SER   A 1 161 ? 150.132 146.991 207.044 1.00 172.71 ? 123 SER   N C   1 
ATOM   847  O O   . SER   A 1 161 ? 149.730 148.147 207.175 1.00 172.05 ? 123 SER   N O   1 
ATOM   848  C CB  . SER   A 1 161 ? 151.409 145.878 205.199 1.00 173.11 ? 123 SER   N CB  1 
ATOM   849  N N   . ALA   B 2 172 ? 115.090 151.466 116.396 1.00 105.31 ? 34  ALA   R N   1 
ATOM   850  C CA  . ALA   B 2 172 ? 116.328 150.814 115.986 1.00 104.32 ? 34  ALA   R CA  1 
ATOM   851  C C   . ALA   B 2 172 ? 117.456 151.829 115.841 1.00 105.76 ? 34  ALA   R C   1 
ATOM   852  O O   . ALA   B 2 172 ? 118.633 151.472 115.884 1.00 106.10 ? 34  ALA   R O   1 
ATOM   853  C CB  . ALA   B 2 172 ? 116.124 150.057 114.683 1.00 101.33 ? 34  ALA   R CB  1 
ATOM   854  N N   . ASN   B 2 173 ? 117.086 153.100 115.663 1.00 105.14 ? 35  ASN   R N   1 
ATOM   855  C CA  . ASN   B 2 173 ? 118.090 154.152 115.541 1.00 104.41 ? 35  ASN   R CA  1 
ATOM   856  C C   . ASN   B 2 173 ? 118.899 154.293 116.824 1.00 100.96 ? 35  ASN   R C   1 
ATOM   857  O O   . ASN   B 2 173 ? 120.123 154.474 116.779 1.00 99.69  ? 35  ASN   R O   1 
ATOM   858  C CB  . ASN   B 2 173 ? 117.422 155.477 115.179 1.00 103.96 ? 35  ASN   R CB  1 
ATOM   859  C CG  . ASN   B 2 173 ? 116.815 155.461 113.792 1.00 105.52 ? 35  ASN   R CG  1 
ATOM   860  O OD1 . ASN   B 2 173 ? 117.238 154.695 112.927 1.00 104.56 ? 35  ASN   R OD1 1 
ATOM   861  N ND2 . ASN   B 2 173 ? 115.816 156.308 113.574 1.00 104.98 ? 35  ASN   R ND2 1 
ATOM   862  N N   . PHE   B 2 174 ? 118.234 154.216 117.978 1.00 97.34  ? 36  PHE   R N   1 
ATOM   863  C CA  . PHE   B 2 174 ? 118.955 154.337 119.239 1.00 99.08  ? 36  PHE   R CA  1 
ATOM   864  C C   . PHE   B 2 174 ? 119.959 153.206 119.409 1.00 103.99 ? 36  PHE   R C   1 
ATOM   865  O O   . PHE   B 2 174 ? 121.089 153.437 119.849 1.00 107.17 ? 36  PHE   R O   1 
ATOM   866  C CB  . PHE   B 2 174 ? 117.987 154.364 120.419 1.00 99.03  ? 36  PHE   R CB  1 
ATOM   867  C CG  . PHE   B 2 174 ? 118.673 154.292 121.754 1.00 103.70 ? 36  PHE   R CG  1 
ATOM   868  C CD1 . PHE   B 2 174 ? 119.546 155.293 122.150 1.00 103.43 ? 36  PHE   R CD1 1 
ATOM   869  C CD2 . PHE   B 2 174 ? 118.461 153.221 122.604 1.00 103.86 ? 36  PHE   R CD2 1 
ATOM   870  C CE1 . PHE   B 2 174 ? 120.188 155.231 123.372 1.00 102.83 ? 36  PHE   R CE1 1 
ATOM   871  C CE2 . PHE   B 2 174 ? 119.100 153.154 123.828 1.00 101.72 ? 36  PHE   R CE2 1 
ATOM   872  C CZ  . PHE   B 2 174 ? 119.964 154.160 124.212 1.00 100.75 ? 36  PHE   R CZ  1 
ATOM   873  N N   . ASN   B 2 175 ? 119.568 151.975 119.070 1.00 94.61  ? 37  ASN   R N   1 
ATOM   874  C CA  . ASN   B 2 175 ? 120.510 150.862 119.148 1.00 95.03  ? 37  ASN   R CA  1 
ATOM   875  C C   . ASN   B 2 175 ? 121.655 151.038 118.157 1.00 93.89  ? 37  ASN   R C   1 
ATOM   876  O O   . ASN   B 2 175 ? 122.822 150.803 118.497 1.00 90.73  ? 37  ASN   R O   1 
ATOM   877  C CB  . ASN   B 2 175 ? 119.784 149.540 118.904 1.00 91.81  ? 37  ASN   R CB  1 
ATOM   878  C CG  . ASN   B 2 175 ? 119.353 148.868 120.192 1.00 93.17  ? 37  ASN   R CG  1 
ATOM   879  O OD1 . ASN   B 2 175 ? 119.380 149.476 121.262 1.00 93.67  ? 37  ASN   R OD1 1 
ATOM   880  N ND2 . ASN   B 2 175 ? 118.958 147.604 120.097 1.00 91.78  ? 37  ASN   R ND2 1 
ATOM   881  N N   . LYS   B 2 176 ? 121.340 151.467 116.931 1.00 87.66  ? 38  LYS   R N   1 
ATOM   882  C CA  . LYS   B 2 176 ? 122.369 151.674 115.917 1.00 82.92  ? 38  LYS   R CA  1 
ATOM   883  C C   . LYS   B 2 176 ? 123.369 152.743 116.336 1.00 85.29  ? 38  LYS   R C   1 
ATOM   884  O O   . LYS   B 2 176 ? 124.533 152.696 115.928 1.00 88.50  ? 38  LYS   R O   1 
ATOM   885  C CB  . LYS   B 2 176 ? 121.718 152.049 114.585 1.00 85.84  ? 38  LYS   R CB  1 
ATOM   886  C CG  . LYS   B 2 176 ? 122.689 152.172 113.423 1.00 88.55  ? 38  LYS   R CG  1 
ATOM   887  C CD  . LYS   B 2 176 ? 121.981 152.620 112.155 1.00 89.61  ? 38  LYS   R CD  1 
ATOM   888  C CE  . LYS   B 2 176 ? 121.151 151.494 111.561 1.00 88.83  ? 38  LYS   R CE  1 
ATOM   889  N NZ  . LYS   B 2 176 ? 120.548 151.877 110.257 1.00 88.24  ? 38  LYS   R NZ  1 
ATOM   890  N N   . ILE   B 2 177 ? 122.937 153.714 117.135 1.00 82.87  ? 39  ILE   R N   1 
ATOM   891  C CA  . ILE   B 2 177 ? 123.859 154.737 117.617 1.00 81.07  ? 39  ILE   R CA  1 
ATOM   892  C C   . ILE   B 2 177 ? 124.572 154.311 118.903 1.00 81.76  ? 39  ILE   R C   1 
ATOM   893  O O   . ILE   B 2 177 ? 125.717 154.711 119.136 1.00 84.12  ? 39  ILE   R O   1 
ATOM   894  C CB  . ILE   B 2 177 ? 123.112 156.068 117.809 1.00 79.66  ? 39  ILE   R CB  1 
ATOM   895  C CG1 . ILE   B 2 177 ? 122.564 156.564 116.470 1.00 85.07  ? 39  ILE   R CG1 1 
ATOM   896  C CG2 . ILE   B 2 177 ? 124.018 157.128 118.413 1.00 80.34  ? 39  ILE   R CG2 1 
ATOM   897  C CD1 . ILE   B 2 177 ? 121.607 157.730 116.596 1.00 84.34  ? 39  ILE   R CD1 1 
ATOM   898  N N   . PHE   B 2 178 ? 123.937 153.479 119.728 1.00 73.78  ? 40  PHE   R N   1 
ATOM   899  C CA  . PHE   B 2 178 ? 124.449 153.155 121.053 1.00 69.91  ? 40  PHE   R CA  1 
ATOM   900  C C   . PHE   B 2 178 ? 125.432 151.988 121.042 1.00 75.57  ? 40  PHE   R C   1 
ATOM   901  O O   . PHE   B 2 178 ? 126.476 152.056 121.696 1.00 81.36  ? 40  PHE   R O   1 
ATOM   902  C CB  . PHE   B 2 178 ? 123.278 152.851 121.993 1.00 70.70  ? 40  PHE   R CB  1 
ATOM   903  C CG  . PHE   B 2 178 ? 123.696 152.435 123.373 1.00 77.93  ? 40  PHE   R CG  1 
ATOM   904  C CD1 . PHE   B 2 178 ? 124.056 153.381 124.316 1.00 81.41  ? 40  PHE   R CD1 1 
ATOM   905  C CD2 . PHE   B 2 178 ? 123.718 151.098 123.731 1.00 78.95  ? 40  PHE   R CD2 1 
ATOM   906  C CE1 . PHE   B 2 178 ? 124.438 153.001 125.588 1.00 81.19  ? 40  PHE   R CE1 1 
ATOM   907  C CE2 . PHE   B 2 178 ? 124.100 150.712 125.001 1.00 74.40  ? 40  PHE   R CE2 1 
ATOM   908  C CZ  . PHE   B 2 178 ? 124.460 151.665 125.930 1.00 76.72  ? 40  PHE   R CZ  1 
ATOM   909  N N   . LEU   B 2 179 ? 125.112 150.909 120.325 1.00 67.79  ? 41  LEU   R N   1 
ATOM   910  C CA  . LEU   B 2 179 ? 125.961 149.718 120.372 1.00 66.23  ? 41  LEU   R CA  1 
ATOM   911  C C   . LEU   B 2 179 ? 127.379 149.962 119.865 1.00 65.93  ? 41  LEU   R C   1 
ATOM   912  O O   . LEU   B 2 179 ? 128.331 149.549 120.551 1.00 65.97  ? 41  LEU   R O   1 
ATOM   913  C CB  . LEU   B 2 179 ? 125.284 148.572 119.613 1.00 62.47  ? 41  LEU   R CB  1 
ATOM   914  C CG  . LEU   B 2 179 ? 124.034 147.986 120.269 1.00 61.46  ? 41  LEU   R CG  1 
ATOM   915  C CD1 . LEU   B 2 179 ? 123.664 146.662 119.629 1.00 62.20  ? 41  LEU   R CD1 1 
ATOM   916  C CD2 . LEU   B 2 179 ? 124.247 147.819 121.758 1.00 65.23  ? 41  LEU   R CD2 1 
ATOM   917  N N   . PRO   B 2 180 ? 127.605 150.590 118.703 1.00 60.56  ? 42  PRO   R N   1 
ATOM   918  C CA  . PRO   B 2 180 ? 128.993 150.839 118.284 1.00 58.82  ? 42  PRO   R CA  1 
ATOM   919  C C   . PRO   B 2 180 ? 129.774 151.705 119.250 1.00 64.95  ? 42  PRO   R C   1 
ATOM   920  O O   . PRO   B 2 180 ? 130.986 151.516 119.385 1.00 66.94  ? 42  PRO   R O   1 
ATOM   921  C CB  . PRO   B 2 180 ? 128.835 151.524 116.921 1.00 57.16  ? 42  PRO   R CB  1 
ATOM   922  C CG  . PRO   B 2 180 ? 127.457 152.047 116.914 1.00 58.37  ? 42  PRO   R CG  1 
ATOM   923  C CD  . PRO   B 2 180 ? 126.655 151.049 117.677 1.00 63.26  ? 42  PRO   R CD  1 
ATOM   924  N N   . THR   B 2 181 ? 129.121 152.651 119.927 1.00 63.61  ? 43  THR   R N   1 
ATOM   925  C CA  . THR   B 2 181 ? 129.824 153.491 120.892 1.00 61.30  ? 43  THR   R CA  1 
ATOM   926  C C   . THR   B 2 181 ? 130.379 152.658 122.042 1.00 66.59  ? 43  THR   R C   1 
ATOM   927  O O   . THR   B 2 181 ? 131.558 152.774 122.401 1.00 75.24  ? 43  THR   R O   1 
ATOM   928  C CB  . THR   B 2 181 ? 128.884 154.574 121.416 1.00 60.53  ? 43  THR   R CB  1 
ATOM   929  O OG1 . THR   B 2 181 ? 128.347 155.312 120.313 1.00 61.08  ? 43  THR   R OG1 1 
ATOM   930  C CG2 . THR   B 2 181 ? 129.627 155.520 122.338 1.00 63.59  ? 43  THR   R CG2 1 
ATOM   931  N N   . ILE   B 2 182 ? 129.540 151.800 122.624 1.00 55.43  ? 44  ILE   R N   1 
ATOM   932  C CA  . ILE   B 2 182 ? 129.984 150.948 123.721 1.00 57.46  ? 44  ILE   R CA  1 
ATOM   933  C C   . ILE   B 2 182 ? 131.042 149.964 123.242 1.00 67.56  ? 44  ILE   R C   1 
ATOM   934  O O   . ILE   B 2 182 ? 132.037 149.716 123.935 1.00 72.63  ? 44  ILE   R O   1 
ATOM   935  C CB  . ILE   B 2 182 ? 128.780 150.231 124.354 1.00 58.05  ? 44  ILE   R CB  1 
ATOM   936  C CG1 . ILE   B 2 182 ? 127.943 151.221 125.160 1.00 61.71  ? 44  ILE   R CG1 1 
ATOM   937  C CG2 . ILE   B 2 182 ? 129.239 149.094 125.242 1.00 59.04  ? 44  ILE   R CG2 1 
ATOM   938  C CD1 . ILE   B 2 182 ? 128.709 151.892 126.272 1.00 65.27  ? 44  ILE   R CD1 1 
ATOM   939  N N   . TYR   B 2 183 ? 130.848 149.385 122.052 1.00 64.77  ? 45  TYR   R N   1 
ATOM   940  C CA  . TYR   B 2 183 ? 131.835 148.447 121.525 1.00 59.41  ? 45  TYR   R CA  1 
ATOM   941  C C   . TYR   B 2 183 ? 133.184 149.124 121.324 1.00 55.77  ? 45  TYR   R C   1 
ATOM   942  O O   . TYR   B 2 183 ? 134.226 148.551 121.654 1.00 54.56  ? 45  TYR   R O   1 
ATOM   943  C CB  . TYR   B 2 183 ? 131.344 147.838 120.212 1.00 56.80  ? 45  TYR   R CB  1 
ATOM   944  C CG  . TYR   B 2 183 ? 130.225 146.841 120.381 1.00 57.72  ? 45  TYR   R CG  1 
ATOM   945  C CD1 . TYR   B 2 183 ? 130.056 146.158 121.573 1.00 57.98  ? 45  TYR   R CD1 1 
ATOM   946  C CD2 . TYR   B 2 183 ? 129.337 146.584 119.349 1.00 58.64  ? 45  TYR   R CD2 1 
ATOM   947  C CE1 . TYR   B 2 183 ? 129.034 145.249 121.732 1.00 61.30  ? 45  TYR   R CE1 1 
ATOM   948  C CE2 . TYR   B 2 183 ? 128.313 145.677 119.500 1.00 57.52  ? 45  TYR   R CE2 1 
ATOM   949  C CZ  . TYR   B 2 183 ? 128.167 145.012 120.694 1.00 61.44  ? 45  TYR   R CZ  1 
ATOM   950  O OH  . TYR   B 2 183 ? 127.146 144.105 120.851 1.00 67.42  ? 45  TYR   R OH  1 
ATOM   951  N N   . SER   B 2 184 ? 133.184 150.347 120.791 1.00 51.77  ? 46  SER   R N   1 
ATOM   952  C CA  . SER   B 2 184 ? 134.431 151.074 120.590 1.00 54.94  ? 46  SER   R CA  1 
ATOM   953  C C   . SER   B 2 184 ? 135.096 151.417 121.916 1.00 56.26  ? 46  SER   R C   1 
ATOM   954  O O   . SER   B 2 184 ? 136.318 151.290 122.051 1.00 59.06  ? 46  SER   R O   1 
ATOM   955  C CB  . SER   B 2 184 ? 134.169 152.339 119.777 1.00 50.73  ? 46  SER   R CB  1 
ATOM   956  O OG  . SER   B 2 184 ? 133.441 152.039 118.601 1.00 54.50  ? 46  SER   R OG  1 
ATOM   957  N N   . ILE   B 2 185 ? 134.316 151.857 122.906 1.00 45.51  ? 47  ILE   R N   1 
ATOM   958  C CA  . ILE   B 2 185 ? 134.898 152.188 124.205 1.00 46.52  ? 47  ILE   R CA  1 
ATOM   959  C C   . ILE   B 2 185 ? 135.545 150.954 124.823 1.00 51.83  ? 47  ILE   R C   1 
ATOM   960  O O   . ILE   B 2 185 ? 136.688 150.998 125.302 1.00 53.38  ? 47  ILE   R O   1 
ATOM   961  C CB  . ILE   B 2 185 ? 133.830 152.795 125.132 1.00 47.68  ? 47  ILE   R CB  1 
ATOM   962  C CG1 . ILE   B 2 185 ? 133.671 154.289 124.854 1.00 49.51  ? 47  ILE   R CG1 1 
ATOM   963  C CG2 . ILE   B 2 185 ? 134.194 152.574 126.589 1.00 49.35  ? 47  ILE   R CG2 1 
ATOM   964  C CD1 . ILE   B 2 185 ? 132.597 154.948 125.685 1.00 53.27  ? 47  ILE   R CD1 1 
ATOM   965  N N   . ILE   B 2 186 ? 134.830 149.827 124.795 1.00 54.43  ? 48  ILE   R N   1 
ATOM   966  C CA  . ILE   B 2 186 ? 135.354 148.596 125.379 1.00 50.33  ? 48  ILE   R CA  1 
ATOM   967  C C   . ILE   B 2 186 ? 136.587 148.125 124.621 1.00 59.14  ? 48  ILE   R C   1 
ATOM   968  O O   . ILE   B 2 186 ? 137.562 147.675 125.225 1.00 60.04  ? 48  ILE   R O   1 
ATOM   969  C CB  . ILE   B 2 186 ? 134.261 147.514 125.417 1.00 49.84  ? 48  ILE   R CB  1 
ATOM   970  C CG1 . ILE   B 2 186 ? 133.196 147.878 126.449 1.00 51.36  ? 48  ILE   R CG1 1 
ATOM   971  C CG2 . ILE   B 2 186 ? 134.861 146.161 125.745 1.00 48.54  ? 48  ILE   R CG2 1 
ATOM   972  C CD1 . ILE   B 2 186 ? 132.005 146.957 126.435 1.00 55.87  ? 48  ILE   R CD1 1 
ATOM   973  N N   . PHE   B 2 187 ? 136.568 148.221 123.290 1.00 54.00  ? 49  PHE   R N   1 
ATOM   974  C CA  . PHE   B 2 187 ? 137.717 147.800 122.496 1.00 38.03  ? 49  PHE   R CA  1 
ATOM   975  C C   . PHE   B 2 187 ? 138.947 148.634 122.827 1.00 50.17  ? 49  PHE   R C   1 
ATOM   976  O O   . PHE   B 2 187 ? 140.028 148.091 123.089 1.00 58.61  ? 49  PHE   R O   1 
ATOM   977  C CB  . PHE   B 2 187 ? 137.375 147.897 121.010 1.00 43.99  ? 49  PHE   R CB  1 
ATOM   978  C CG  . PHE   B 2 187 ? 138.567 147.847 120.098 1.00 51.37  ? 49  PHE   R CG  1 
ATOM   979  C CD1 . PHE   B 2 187 ? 139.167 146.642 119.786 1.00 55.35  ? 49  PHE   R CD1 1 
ATOM   980  C CD2 . PHE   B 2 187 ? 139.073 149.003 119.533 1.00 52.93  ? 49  PHE   R CD2 1 
ATOM   981  C CE1 . PHE   B 2 187 ? 140.255 146.594 118.939 1.00 52.87  ? 49  PHE   R CE1 1 
ATOM   982  C CE2 . PHE   B 2 187 ? 140.162 148.960 118.688 1.00 51.13  ? 49  PHE   R CE2 1 
ATOM   983  C CZ  . PHE   B 2 187 ? 140.754 147.755 118.391 1.00 48.99  ? 49  PHE   R CZ  1 
ATOM   984  N N   . LEU   B 2 188 ? 138.794 149.961 122.839 1.00 59.05  ? 50  LEU   R N   1 
ATOM   985  C CA  . LEU   B 2 188 ? 139.928 150.835 123.120 1.00 56.81  ? 50  LEU   R CA  1 
ATOM   986  C C   . LEU   B 2 188 ? 140.483 150.608 124.520 1.00 56.82  ? 50  LEU   R C   1 
ATOM   987  O O   . LEU   B 2 188 ? 141.705 150.583 124.708 1.00 60.63  ? 50  LEU   R O   1 
ATOM   988  C CB  . LEU   B 2 188 ? 139.533 152.299 122.928 1.00 53.90  ? 50  LEU   R CB  1 
ATOM   989  C CG  . LEU   B 2 188 ? 139.721 152.907 121.534 1.00 60.85  ? 50  LEU   R CG  1 
ATOM   990  C CD1 . LEU   B 2 188 ? 138.746 152.353 120.515 1.00 58.20  ? 50  LEU   R CD1 1 
ATOM   991  C CD2 . LEU   B 2 188 ? 139.600 154.420 121.611 1.00 64.78  ? 50  LEU   R CD2 1 
ATOM   992  N N   . THR   B 2 189 ? 139.614 150.447 125.519 1.00 47.06  ? 51  THR   R N   1 
ATOM   993  C CA  . THR   B 2 189 ? 140.120 150.218 126.870 1.00 52.43  ? 51  THR   R CA  1 
ATOM   994  C C   . THR   B 2 189 ? 140.762 148.839 126.996 1.00 57.10  ? 51  THR   R C   1 
ATOM   995  O O   . THR   B 2 189 ? 141.852 148.701 127.566 1.00 64.09  ? 51  THR   R O   1 
ATOM   996  C CB  . THR   B 2 189 ? 138.999 150.386 127.896 1.00 58.88  ? 51  THR   R CB  1 
ATOM   997  O OG1 . THR   B 2 189 ? 137.888 149.558 127.535 1.00 70.28  ? 51  THR   R OG1 1 
ATOM   998  C CG2 . THR   B 2 189 ? 138.550 151.836 127.959 1.00 56.46  ? 51  THR   R CG2 1 
ATOM   999  N N   . GLY   B 2 190 ? 140.103 147.808 126.464 1.00 54.70  ? 52  GLY   R N   1 
ATOM   1000 C CA  . GLY   B 2 190 ? 140.574 146.449 126.654 1.00 48.54  ? 52  GLY   R CA  1 
ATOM   1001 C C   . GLY   B 2 190 ? 141.878 146.160 125.941 1.00 55.59  ? 52  GLY   R C   1 
ATOM   1002 O O   . GLY   B 2 190 ? 142.749 145.485 126.491 1.00 54.41  ? 52  GLY   R O   1 
ATOM   1003 N N   . ILE   B 2 191 ? 142.036 146.659 124.711 1.00 60.43  ? 53  ILE   R N   1 
ATOM   1004 C CA  . ILE   B 2 191 ? 143.287 146.435 123.991 1.00 51.20  ? 53  ILE   R CA  1 
ATOM   1005 C C   . ILE   B 2 191 ? 144.459 146.959 124.806 1.00 55.23  ? 53  ILE   R C   1 
ATOM   1006 O O   . ILE   B 2 191 ? 145.424 146.235 125.075 1.00 58.77  ? 53  ILE   R O   1 
ATOM   1007 C CB  . ILE   B 2 191 ? 143.237 147.093 122.601 1.00 49.58  ? 53  ILE   R CB  1 
ATOM   1008 C CG1 . ILE   B 2 191 ? 142.382 146.270 121.645 1.00 52.15  ? 53  ILE   R CG1 1 
ATOM   1009 C CG2 . ILE   B 2 191 ? 144.637 147.258 122.039 1.00 53.43  ? 53  ILE   R CG2 1 
ATOM   1010 C CD1 . ILE   B 2 191 ? 142.977 144.934 121.311 1.00 53.97  ? 53  ILE   R CD1 1 
ATOM   1011 N N   . VAL   B 2 192 ? 144.362 148.211 125.256 1.00 50.06  ? 54  VAL   R N   1 
ATOM   1012 C CA  . VAL   B 2 192 ? 145.463 148.828 125.988 1.00 53.68  ? 54  VAL   R CA  1 
ATOM   1013 C C   . VAL   B 2 192 ? 145.699 148.104 127.306 1.00 53.11  ? 54  VAL   R C   1 
ATOM   1014 O O   . VAL   B 2 192 ? 146.837 147.756 127.646 1.00 59.98  ? 54  VAL   R O   1 
ATOM   1015 C CB  . VAL   B 2 192 ? 145.188 150.326 126.204 1.00 51.48  ? 54  VAL   R CB  1 
ATOM   1016 C CG1 . VAL   B 2 192 ? 146.144 150.900 127.235 1.00 56.79  ? 54  VAL   R CG1 1 
ATOM   1017 C CG2 . VAL   B 2 192 ? 145.305 151.076 124.890 1.00 52.09  ? 54  VAL   R CG2 1 
ATOM   1018 N N   . GLY   B 2 193 ? 144.627 147.843 128.059 1.00 43.40  ? 55  GLY   R N   1 
ATOM   1019 C CA  . GLY   B 2 193 ? 144.797 147.220 129.362 1.00 43.85  ? 55  GLY   R CA  1 
ATOM   1020 C C   . GLY   B 2 193 ? 145.400 145.831 129.279 1.00 57.72  ? 55  GLY   R C   1 
ATOM   1021 O O   . GLY   B 2 193 ? 146.360 145.513 129.987 1.00 60.24  ? 55  GLY   R O   1 
ATOM   1022 N N   . ASN   B 2 194 ? 144.856 144.988 128.397 1.00 59.12  ? 56  ASN   R N   1 
ATOM   1023 C CA  . ASN   B 2 194 ? 145.330 143.613 128.305 1.00 47.61  ? 56  ASN   R CA  1 
ATOM   1024 C C   . ASN   B 2 194 ? 146.725 143.543 127.699 1.00 49.16  ? 56  ASN   R C   1 
ATOM   1025 O O   . ASN   B 2 194 ? 147.553 142.740 128.142 1.00 58.76  ? 56  ASN   R O   1 
ATOM   1026 C CB  . ASN   B 2 194 ? 144.340 142.774 127.503 1.00 37.70  ? 56  ASN   R CB  1 
ATOM   1027 C CG  . ASN   B 2 194 ? 143.022 142.595 128.223 1.00 40.47  ? 56  ASN   R CG  1 
ATOM   1028 O OD1 . ASN   B 2 194 ? 142.986 142.446 129.441 1.00 44.87  ? 56  ASN   R OD1 1 
ATOM   1029 N ND2 . ASN   B 2 194 ? 141.931 142.610 127.474 1.00 45.12  ? 56  ASN   R ND2 1 
ATOM   1030 N N   . GLY   B 2 195 ? 147.017 144.376 126.697 1.00 50.12  ? 57  GLY   R N   1 
ATOM   1031 C CA  . GLY   B 2 195 ? 148.371 144.424 126.181 1.00 50.93  ? 57  GLY   R CA  1 
ATOM   1032 C C   . GLY   B 2 195 ? 149.375 144.843 127.235 1.00 57.04  ? 57  GLY   R C   1 
ATOM   1033 O O   . GLY   B 2 195 ? 150.452 144.253 127.346 1.00 54.14  ? 57  GLY   R O   1 
ATOM   1034 N N   . LEU   B 2 196 ? 149.031 145.858 128.036 1.00 60.60  ? 58  LEU   R N   1 
ATOM   1035 C CA  . LEU   B 2 196 ? 149.937 146.302 129.089 1.00 59.49  ? 58  LEU   R CA  1 
ATOM   1036 C C   . LEU   B 2 196 ? 150.147 145.215 130.136 1.00 61.39  ? 58  LEU   R C   1 
ATOM   1037 O O   . LEU   B 2 196 ? 151.278 144.983 130.580 1.00 69.03  ? 58  LEU   R O   1 
ATOM   1038 C CB  . LEU   B 2 196 ? 149.399 147.574 129.740 1.00 51.04  ? 58  LEU   R CB  1 
ATOM   1039 C CG  . LEU   B 2 196 ? 149.636 148.860 128.955 1.00 55.57  ? 58  LEU   R CG  1 
ATOM   1040 C CD1 . LEU   B 2 196 ? 149.064 150.053 129.701 1.00 60.97  ? 58  LEU   R CD1 1 
ATOM   1041 C CD2 . LEU   B 2 196 ? 151.119 149.048 128.687 1.00 61.46  ? 58  LEU   R CD2 1 
ATOM   1042 N N   . VAL   B 2 197 ? 149.071 144.538 130.542 1.00 54.18  ? 59  VAL   R N   1 
ATOM   1043 C CA  . VAL   B 2 197 ? 149.201 143.482 131.543 1.00 57.09  ? 59  VAL   R CA  1 
ATOM   1044 C C   . VAL   B 2 197 ? 150.079 142.356 131.014 1.00 64.93  ? 59  VAL   R C   1 
ATOM   1045 O O   . VAL   B 2 197 ? 150.981 141.869 131.707 1.00 63.79  ? 59  VAL   R O   1 
ATOM   1046 C CB  . VAL   B 2 197 ? 147.814 142.966 131.968 1.00 55.94  ? 59  VAL   R CB  1 
ATOM   1047 C CG1 . VAL   B 2 197 ? 147.943 141.629 132.665 1.00 53.58  ? 59  VAL   R CG1 1 
ATOM   1048 C CG2 . VAL   B 2 197 ? 147.133 143.970 132.878 1.00 61.63  ? 59  VAL   R CG2 1 
ATOM   1049 N N   . ILE   B 2 198 ? 149.836 141.933 129.771 1.00 63.89  ? 60  ILE   R N   1 
ATOM   1050 C CA  . ILE   B 2 198 ? 150.613 140.838 129.197 1.00 51.12  ? 60  ILE   R CA  1 
ATOM   1051 C C   . ILE   B 2 198 ? 152.079 141.230 129.075 1.00 54.25  ? 60  ILE   R C   1 
ATOM   1052 O O   . ILE   B 2 198 ? 152.971 140.446 129.413 1.00 64.29  ? 60  ILE   R O   1 
ATOM   1053 C CB  . ILE   B 2 198 ? 150.020 140.410 127.842 1.00 50.84  ? 60  ILE   R CB  1 
ATOM   1054 C CG1 . ILE   B 2 198 ? 148.793 139.527 128.058 1.00 48.62  ? 60  ILE   R CG1 1 
ATOM   1055 C CG2 . ILE   B 2 198 ? 151.051 139.665 127.016 1.00 52.86  ? 60  ILE   R CG2 1 
ATOM   1056 C CD1 . ILE   B 2 198 ? 148.046 139.215 126.790 1.00 52.39  ? 60  ILE   R CD1 1 
ATOM   1057 N N   . LEU   B 2 199 ? 152.356 142.448 128.601 1.00 58.50  ? 61  LEU   R N   1 
ATOM   1058 C CA  . LEU   B 2 199 ? 153.741 142.898 128.510 1.00 59.40  ? 61  LEU   R CA  1 
ATOM   1059 C C   . LEU   B 2 199 ? 154.414 142.870 129.874 1.00 66.17  ? 61  LEU   R C   1 
ATOM   1060 O O   . LEU   B 2 199 ? 155.465 142.238 130.045 1.00 70.19  ? 61  LEU   R O   1 
ATOM   1061 C CB  . LEU   B 2 199 ? 153.806 144.305 127.916 1.00 57.94  ? 61  LEU   R CB  1 
ATOM   1062 C CG  . LEU   B 2 199 ? 153.605 144.455 126.409 1.00 68.70  ? 61  LEU   R CG  1 
ATOM   1063 C CD1 . LEU   B 2 199 ? 153.643 145.922 126.012 1.00 68.11  ? 61  LEU   R CD1 1 
ATOM   1064 C CD2 . LEU   B 2 199 ? 154.658 143.669 125.652 1.00 69.62  ? 61  LEU   R CD2 1 
ATOM   1065 N N   . VAL   B 2 200 ? 153.788 143.506 130.870 1.00 70.97  ? 62  VAL   R N   1 
ATOM   1066 C CA  . VAL   B 2 200 ? 154.407 143.649 132.185 1.00 67.48  ? 62  VAL   R CA  1 
ATOM   1067 C C   . VAL   B 2 200 ? 154.657 142.286 132.817 1.00 74.72  ? 62  VAL   R C   1 
ATOM   1068 O O   . VAL   B 2 200 ? 155.707 142.054 133.428 1.00 83.66  ? 62  VAL   R O   1 
ATOM   1069 C CB  . VAL   B 2 200 ? 153.537 144.543 133.088 1.00 71.75  ? 62  VAL   R CB  1 
ATOM   1070 C CG1 . VAL   B 2 200 ? 153.874 144.321 134.552 1.00 71.87  ? 62  VAL   R CG1 1 
ATOM   1071 C CG2 . VAL   B 2 200 ? 153.719 146.004 132.716 1.00 75.94  ? 62  VAL   R CG2 1 
ATOM   1072 N N   . MET   B 2 201 ? 153.710 141.358 132.678 1.00 76.42  ? 63  MET   R N   1 
ATOM   1073 C CA  . MET   B 2 201 ? 153.896 140.051 133.299 1.00 73.62  ? 63  MET   R CA  1 
ATOM   1074 C C   . MET   B 2 201 ? 154.878 139.188 132.515 1.00 78.33  ? 63  MET   R C   1 
ATOM   1075 O O   . MET   B 2 201 ? 155.918 138.781 133.042 1.00 80.51  ? 63  MET   R O   1 
ATOM   1076 C CB  . MET   B 2 201 ? 152.552 139.341 133.451 1.00 69.32  ? 63  MET   R CB  1 
ATOM   1077 C CG  . MET   B 2 201 ? 151.558 140.136 134.252 1.00 75.46  ? 63  MET   R CG  1 
ATOM   1078 S SD  . MET   B 2 201 ? 152.108 140.260 135.956 1.00 92.78  ? 63  MET   R SD  1 
ATOM   1079 C CE  . MET   B 2 201 ? 150.573 140.017 136.823 1.00 75.23  ? 63  MET   R CE  1 
ATOM   1080 N N   . GLY   B 2 202 ? 154.566 138.892 131.256 1.00 81.09  ? 64  GLY   R N   1 
ATOM   1081 C CA  . GLY   B 2 202 ? 155.403 138.002 130.485 1.00 78.09  ? 64  GLY   R CA  1 
ATOM   1082 C C   . GLY   B 2 202 ? 156.724 138.606 130.061 1.00 79.21  ? 64  GLY   R C   1 
ATOM   1083 O O   . GLY   B 2 202 ? 157.784 138.122 130.468 1.00 84.41  ? 64  GLY   R O   1 
ATOM   1084 N N   . TYR   B 2 203 ? 156.686 139.667 129.254 1.00 95.70  ? 65  TYR   R N   1 
ATOM   1085 C CA  . TYR   B 2 203 ? 157.910 140.125 128.610 1.00 98.60  ? 65  TYR   R CA  1 
ATOM   1086 C C   . TYR   B 2 203 ? 158.806 140.924 129.543 1.00 101.83 ? 65  TYR   R C   1 
ATOM   1087 O O   . TYR   B 2 203 ? 160.001 141.064 129.260 1.00 103.35 ? 65  TYR   R O   1 
ATOM   1088 C CB  . TYR   B 2 203 ? 157.576 140.951 127.367 1.00 96.73  ? 65  TYR   R CB  1 
ATOM   1089 C CG  . TYR   B 2 203 ? 157.025 140.126 126.225 1.00 98.12  ? 65  TYR   R CG  1 
ATOM   1090 C CD1 . TYR   B 2 203 ? 157.052 138.738 126.270 1.00 97.98  ? 65  TYR   R CD1 1 
ATOM   1091 C CD2 . TYR   B 2 203 ? 156.484 140.733 125.101 1.00 99.72  ? 65  TYR   R CD2 1 
ATOM   1092 C CE1 . TYR   B 2 203 ? 156.550 137.979 125.229 1.00 101.41 ? 65  TYR   R CE1 1 
ATOM   1093 C CE2 . TYR   B 2 203 ? 155.980 139.983 124.054 1.00 99.73  ? 65  TYR   R CE2 1 
ATOM   1094 C CZ  . TYR   B 2 203 ? 156.017 138.607 124.124 1.00 102.54 ? 65  TYR   R CZ  1 
ATOM   1095 O OH  . TYR   B 2 203 ? 155.518 137.856 123.085 1.00 100.71 ? 65  TYR   R OH  1 
ATOM   1096 N N   . GLN   B 2 204 ? 158.266 141.450 130.640 1.00 95.16  ? 66  GLN   R N   1 
ATOM   1097 C CA  . GLN   B 2 204 ? 159.075 142.118 131.647 1.00 93.51  ? 66  GLN   R CA  1 
ATOM   1098 C C   . GLN   B 2 204 ? 159.463 141.195 132.796 1.00 95.61  ? 66  GLN   R C   1 
ATOM   1099 O O   . GLN   B 2 204 ? 160.224 141.614 133.675 1.00 97.25  ? 66  GLN   R O   1 
ATOM   1100 C CB  . GLN   B 2 204 ? 158.333 143.345 132.190 1.00 91.09  ? 66  GLN   R CB  1 
ATOM   1101 C CG  . GLN   B 2 204 ? 159.239 144.496 132.592 1.00 95.06  ? 66  GLN   R CG  1 
ATOM   1102 C CD  . GLN   B 2 204 ? 158.519 145.831 132.589 1.00 99.29  ? 66  GLN   R CD  1 
ATOM   1103 O OE1 . GLN   B 2 204 ? 157.359 145.922 132.190 1.00 100.73 ? 66  GLN   R OE1 1 
ATOM   1104 N NE2 . GLN   B 2 204 ? 159.205 146.875 133.037 1.00 98.11  ? 66  GLN   R NE2 1 
ATOM   1105 N N   . LYS   B 2 205 ? 158.957 139.959 132.805 1.00 95.62  ? 67  LYS   R N   1 
ATOM   1106 C CA  . LYS   B 2 205 ? 159.322 138.936 133.790 1.00 97.77  ? 67  LYS   R CA  1 
ATOM   1107 C C   . LYS   B 2 205 ? 159.073 139.395 135.224 1.00 97.23  ? 67  LYS   R C   1 
ATOM   1108 O O   . LYS   B 2 205 ? 159.766 138.967 136.150 1.00 97.89  ? 67  LYS   R O   1 
ATOM   1109 C CB  . LYS   B 2 205 ? 160.779 138.490 133.625 1.00 97.38  ? 67  LYS   R CB  1 
ATOM   1110 C CG  . LYS   B 2 205 ? 160.997 137.396 132.588 1.00 95.89  ? 67  LYS   R CG  1 
ATOM   1111 C CD  . LYS   B 2 205 ? 160.955 137.935 131.168 1.00 94.53  ? 67  LYS   R CD  1 
ATOM   1112 C CE  . LYS   B 2 205 ? 162.176 138.788 130.869 1.00 94.45  ? 67  LYS   R CE  1 
ATOM   1113 N NZ  . LYS   B 2 205 ? 162.198 139.259 129.457 1.00 93.92  ? 67  LYS   R NZ  1 
ATOM   1114 N N   . LYS   B 2 206 ? 158.084 140.260 135.426 1.00 93.81  ? 68  LYS   R N   1 
ATOM   1115 C CA  . LYS   B 2 206 ? 157.752 140.734 136.763 1.00 93.60  ? 68  LYS   R CA  1 
ATOM   1116 C C   . LYS   B 2 206 ? 156.891 139.694 137.476 1.00 93.11  ? 68  LYS   R C   1 
ATOM   1117 O O   . LYS   B 2 206 ? 156.804 138.536 137.058 1.00 93.03  ? 68  LYS   R O   1 
ATOM   1118 C CB  . LYS   B 2 206 ? 157.083 142.104 136.697 1.00 90.60  ? 68  LYS   R CB  1 
ATOM   1119 C CG  . LYS   B 2 206 ? 158.028 143.224 136.300 1.00 92.07  ? 68  LYS   R CG  1 
ATOM   1120 C CD  . LYS   B 2 206 ? 157.300 144.549 136.202 1.00 97.09  ? 68  LYS   R CD  1 
ATOM   1121 C CE  . LYS   B 2 206 ? 156.908 145.051 137.582 1.00 97.37  ? 68  LYS   R CE  1 
ATOM   1122 N NZ  . LYS   B 2 206 ? 156.306 146.412 137.534 1.00 95.73  ? 68  LYS   R NZ  1 
ATOM   1123 N N   . LEU   B 2 207 ? 156.263 140.106 138.579 1.00 92.54  ? 69  LEU   R N   1 
ATOM   1124 C CA  . LEU   B 2 207 ? 155.542 139.206 139.475 1.00 93.30  ? 69  LEU   R CA  1 
ATOM   1125 C C   . LEU   B 2 207 ? 154.635 138.257 138.708 1.00 94.06  ? 69  LEU   R C   1 
ATOM   1126 O O   . LEU   B 2 207 ? 153.699 138.688 138.031 1.00 91.55  ? 69  LEU   R O   1 
ATOM   1127 C CB  . LEU   B 2 207 ? 154.716 140.023 140.471 1.00 92.40  ? 69  LEU   R CB  1 
ATOM   1128 C CG  . LEU   B 2 207 ? 155.447 140.792 141.571 1.00 90.85  ? 69  LEU   R CG  1 
ATOM   1129 C CD1 . LEU   B 2 207 ? 155.706 142.228 141.142 1.00 91.62  ? 69  LEU   R CD1 1 
ATOM   1130 C CD2 . LEU   B 2 207 ? 154.649 140.751 142.864 1.00 88.12  ? 69  LEU   R CD2 1 
ATOM   1131 N N   . ARG   B 2 208 ? 154.920 136.963 138.813 1.00 96.22  ? 70  ARG   R N   1 
ATOM   1132 C CA  . ARG   B 2 208 ? 154.124 135.933 138.154 1.00 91.50  ? 70  ARG   R CA  1 
ATOM   1133 C C   . ARG   B 2 208 ? 153.859 134.779 139.116 1.00 96.98  ? 70  ARG   R C   1 
ATOM   1134 O O   . ARG   B 2 208 ? 154.065 133.608 138.795 1.00 95.01  ? 70  ARG   R O   1 
ATOM   1135 C CB  . ARG   B 2 208 ? 154.796 135.447 136.873 1.00 90.14  ? 70  ARG   R CB  1 
ATOM   1136 C CG  . ARG   B 2 208 ? 153.806 135.078 135.780 1.00 88.63  ? 70  ARG   R CG  1 
ATOM   1137 C CD  . ARG   B 2 208 ? 154.488 134.913 134.436 1.00 91.86  ? 70  ARG   R CD  1 
ATOM   1138 N NE  . ARG   B 2 208 ? 155.267 133.684 134.368 1.00 94.50  ? 70  ARG   R NE  1 
ATOM   1139 C CZ  . ARG   B 2 208 ? 155.931 133.278 133.296 1.00 95.87  ? 70  ARG   R CZ  1 
ATOM   1140 N NH1 . ARG   B 2 208 ? 155.926 133.979 132.174 1.00 92.68  ? 70  ARG   R NH1 1 
ATOM   1141 N NH2 . ARG   B 2 208 ? 156.616 132.140 133.350 1.00 95.18  ? 70  ARG   R NH2 1 
ATOM   1142 N N   . SER   B 2 209 ? 153.400 135.107 140.323 1.00 96.20  ? 71  SER   R N   1 
ATOM   1143 C CA  . SER   B 2 209 ? 152.996 134.088 141.281 1.00 89.32  ? 71  SER   R CA  1 
ATOM   1144 C C   . SER   B 2 209 ? 151.765 133.347 140.758 1.00 88.13  ? 71  SER   R C   1 
ATOM   1145 O O   . SER   B 2 209 ? 151.258 133.618 139.665 1.00 94.36  ? 71  SER   R O   1 
ATOM   1146 C CB  . SER   B 2 209 ? 152.731 134.714 142.649 1.00 80.97  ? 71  SER   R CB  1 
ATOM   1147 O OG  . SER   B 2 209 ? 151.432 135.270 142.720 1.00 77.87  ? 71  SER   R OG  1 
ATOM   1148 N N   . MET   B 2 210 ? 151.283 132.388 141.551 1.00 71.86  ? 72  MET   R N   1 
ATOM   1149 C CA  . MET   B 2 210 ? 150.232 131.491 141.078 1.00 72.54  ? 72  MET   R CA  1 
ATOM   1150 C C   . MET   B 2 210 ? 149.003 132.269 140.621 1.00 73.36  ? 72  MET   R C   1 
ATOM   1151 O O   . MET   B 2 210 ? 148.530 132.100 139.489 1.00 86.23  ? 72  MET   R O   1 
ATOM   1152 C CB  . MET   B 2 210 ? 149.867 130.499 142.180 1.00 78.23  ? 72  MET   R CB  1 
ATOM   1153 C CG  . MET   B 2 210 ? 151.028 129.627 142.631 1.00 80.56  ? 72  MET   R CG  1 
ATOM   1154 S SD  . MET   B 2 210 ? 151.670 128.561 141.329 1.00 98.03  ? 72  MET   R SD  1 
ATOM   1155 C CE  . MET   B 2 210 ? 153.125 127.896 142.131 1.00 76.68  ? 72  MET   R CE  1 
ATOM   1156 N N   . THR   B 2 211 ? 148.491 133.152 141.479 1.00 55.75  ? 73  THR   R N   1 
ATOM   1157 C CA  . THR   B 2 211 ? 147.359 133.986 141.088 1.00 57.53  ? 73  THR   R CA  1 
ATOM   1158 C C   . THR   B 2 211 ? 147.723 134.876 139.907 1.00 59.79  ? 73  THR   R C   1 
ATOM   1159 O O   . THR   B 2 211 ? 146.895 135.119 139.022 1.00 60.79  ? 73  THR   R O   1 
ATOM   1160 C CB  . THR   B 2 211 ? 146.888 134.822 142.279 1.00 56.26  ? 73  THR   R CB  1 
ATOM   1161 O OG1 . THR   B 2 211 ? 146.483 133.953 143.342 1.00 56.53  ? 73  THR   R OG1 1 
ATOM   1162 C CG2 . THR   B 2 211 ? 145.716 135.701 141.890 1.00 60.59  ? 73  THR   R CG2 1 
ATOM   1163 N N   . ASP   B 2 212 ? 148.968 135.351 139.861 1.00 66.86  ? 74  ASP   R N   1 
ATOM   1164 C CA  . ASP   B 2 212 ? 149.404 136.159 138.729 1.00 61.48  ? 74  ASP   R CA  1 
ATOM   1165 C C   . ASP   B 2 212 ? 149.533 135.331 137.455 1.00 61.85  ? 74  ASP   R C   1 
ATOM   1166 O O   . ASP   B 2 212 ? 149.274 135.845 136.365 1.00 69.83  ? 74  ASP   R O   1 
ATOM   1167 C CB  . ASP   B 2 212 ? 150.719 136.857 139.059 1.00 63.59  ? 74  ASP   R CB  1 
ATOM   1168 C CG  . ASP   B 2 212 ? 150.527 138.038 139.987 1.00 68.16  ? 74  ASP   R CG  1 
ATOM   1169 O OD1 . ASP   B 2 212 ? 149.484 138.714 139.878 1.00 66.01  ? 74  ASP   R OD1 1 
ATOM   1170 O OD2 . ASP   B 2 212 ? 151.415 138.292 140.827 1.00 68.26  ? 74  ASP   R OD2 1 
ATOM   1171 N N   . LYS   B 2 213 ? 149.916 134.057 137.563 1.00 63.16  ? 75  LYS   R N   1 
ATOM   1172 C CA  . LYS   B 2 213 ? 149.888 133.179 136.394 1.00 64.10  ? 75  LYS   R CA  1 
ATOM   1173 C C   . LYS   B 2 213 ? 148.467 133.021 135.866 1.00 63.13  ? 75  LYS   R C   1 
ATOM   1174 O O   . LYS   B 2 213 ? 148.218 133.122 134.655 1.00 71.04  ? 75  LYS   R O   1 
ATOM   1175 C CB  . LYS   B 2 213 ? 150.473 131.811 136.746 1.00 65.46  ? 75  LYS   R CB  1 
ATOM   1176 C CG  . LYS   B 2 213 ? 151.985 131.725 136.695 1.00 70.28  ? 75  LYS   R CG  1 
ATOM   1177 C CD  . LYS   B 2 213 ? 152.433 130.272 136.684 1.00 72.33  ? 75  LYS   R CD  1 
ATOM   1178 C CE  . LYS   B 2 213 ? 153.943 130.151 136.715 1.00 72.44  ? 75  LYS   R CE  1 
ATOM   1179 N NZ  . LYS   B 2 213 ? 154.495 130.555 138.036 1.00 68.70  ? 75  LYS   R NZ  1 
ATOM   1180 N N   . TYR   B 2 214 ? 147.515 132.778 136.771 1.00 47.71  ? 76  TYR   R N   1 
ATOM   1181 C CA  . TYR   B 2 214 ? 146.123 132.662 136.352 1.00 37.27  ? 76  TYR   R CA  1 
ATOM   1182 C C   . TYR   B 2 214 ? 145.636 133.950 135.702 1.00 54.78  ? 76  TYR   R C   1 
ATOM   1183 O O   . TYR   B 2 214 ? 144.917 133.919 134.696 1.00 67.61  ? 76  TYR   R O   1 
ATOM   1184 C CB  . TYR   B 2 214 ? 145.239 132.313 137.543 1.00 43.83  ? 76  TYR   R CB  1 
ATOM   1185 C CG  . TYR   B 2 214 ? 145.534 130.983 138.189 1.00 54.95  ? 76  TYR   R CG  1 
ATOM   1186 C CD1 . TYR   B 2 214 ? 145.500 129.809 137.455 1.00 54.45  ? 76  TYR   R CD1 1 
ATOM   1187 C CD2 . TYR   B 2 214 ? 145.821 130.900 139.543 1.00 52.57  ? 76  TYR   R CD2 1 
ATOM   1188 C CE1 . TYR   B 2 214 ? 145.760 128.592 138.049 1.00 55.64  ? 76  TYR   R CE1 1 
ATOM   1189 C CE2 . TYR   B 2 214 ? 146.086 129.694 140.143 1.00 51.29  ? 76  TYR   R CE2 1 
ATOM   1190 C CZ  . TYR   B 2 214 ? 146.052 128.542 139.395 1.00 59.34  ? 76  TYR   R CZ  1 
ATOM   1191 O OH  . TYR   B 2 214 ? 146.311 127.336 139.999 1.00 64.04  ? 76  TYR   R OH  1 
ATOM   1192 N N   . ARG   B 2 215 ? 146.021 135.098 136.256 1.00 55.97  ? 77  ARG   R N   1 
ATOM   1193 C CA  . ARG   B 2 215 ? 145.548 136.357 135.698 1.00 51.32  ? 77  ARG   R CA  1 
ATOM   1194 C C   . ARG   B 2 215 ? 146.236 136.681 134.376 1.00 51.77  ? 77  ARG   R C   1 
ATOM   1195 O O   . ARG   B 2 215 ? 145.651 137.365 133.531 1.00 62.24  ? 77  ARG   R O   1 
ATOM   1196 C CB  . ARG   B 2 215 ? 145.747 137.485 136.708 1.00 49.02  ? 77  ARG   R CB  1 
ATOM   1197 C CG  . ARG   B 2 215 ? 144.800 138.644 136.486 1.00 58.31  ? 77  ARG   R CG  1 
ATOM   1198 C CD  . ARG   B 2 215 ? 144.802 139.613 137.650 1.00 59.24  ? 77  ARG   R CD  1 
ATOM   1199 N NE  . ARG   B 2 215 ? 144.419 139.001 138.914 1.00 57.97  ? 77  ARG   R NE  1 
ATOM   1200 C CZ  . ARG   B 2 215 ? 144.389 139.648 140.070 1.00 61.54  ? 77  ARG   R CZ  1 
ATOM   1201 N NH1 . ARG   B 2 215 ? 144.676 140.936 140.148 1.00 52.97  ? 77  ARG   R NH1 1 
ATOM   1202 N NH2 . ARG   B 2 215 ? 144.058 138.986 141.175 1.00 63.89  ? 77  ARG   R NH2 1 
ATOM   1203 N N   . LEU   B 2 216 ? 147.461 136.194 134.170 1.00 49.82  ? 78  LEU   R N   1 
ATOM   1204 C CA  . LEU   B 2 216 ? 148.086 136.287 132.854 1.00 46.55  ? 78  LEU   R CA  1 
ATOM   1205 C C   . LEU   B 2 216 ? 147.318 135.471 131.823 1.00 41.33  ? 78  LEU   R C   1 
ATOM   1206 O O   . LEU   B 2 216 ? 147.104 135.928 130.693 1.00 55.85  ? 78  LEU   R O   1 
ATOM   1207 C CB  . LEU   B 2 216 ? 149.540 135.823 132.928 1.00 47.63  ? 78  LEU   R CB  1 
ATOM   1208 C CG  . LEU   B 2 216 ? 150.281 135.675 131.599 1.00 47.65  ? 78  LEU   R CG  1 
ATOM   1209 C CD1 . LEU   B 2 216 ? 150.453 137.019 130.924 1.00 52.56  ? 78  LEU   R CD1 1 
ATOM   1210 C CD2 . LEU   B 2 216 ? 151.627 135.008 131.808 1.00 48.53  ? 78  LEU   R CD2 1 
ATOM   1211 N N   . HIS   B 2 217 ? 146.896 134.259 132.194 1.00 28.24  ? 79  HIS   R N   1 
ATOM   1212 C CA  . HIS   B 2 217 ? 146.024 133.489 131.309 1.00 30.22  ? 79  HIS   R CA  1 
ATOM   1213 C C   . HIS   B 2 217 ? 144.746 134.262 131.003 1.00 37.75  ? 79  HIS   R C   1 
ATOM   1214 O O   . HIS   B 2 217 ? 144.278 134.300 129.852 1.00 48.25  ? 79  HIS   R O   1 
ATOM   1215 C CB  . HIS   B 2 217 ? 145.682 132.144 131.950 1.00 41.64  ? 79  HIS   R CB  1 
ATOM   1216 C CG  . HIS   B 2 217 ? 146.786 131.134 131.887 1.00 47.44  ? 79  HIS   R CG  1 
ATOM   1217 N ND1 . HIS   B 2 217 ? 146.754 130.050 131.038 1.00 53.72  ? 79  HIS   R ND1 1 
ATOM   1218 C CD2 . HIS   B 2 217 ? 147.950 131.042 132.570 1.00 50.62  ? 79  HIS   R CD2 1 
ATOM   1219 C CE1 . HIS   B 2 217 ? 147.851 129.333 131.201 1.00 52.96  ? 79  HIS   R CE1 1 
ATOM   1220 N NE2 . HIS   B 2 217 ? 148.594 129.914 132.124 1.00 55.18  ? 79  HIS   R NE2 1 
ATOM   1221 N N   . LEU   B 2 218 ? 144.172 134.886 132.033 1.00 41.25  ? 80  LEU   R N   1 
ATOM   1222 C CA  . LEU   B 2 218 ? 142.945 135.660 131.876 1.00 40.08  ? 80  LEU   R CA  1 
ATOM   1223 C C   . LEU   B 2 218 ? 143.132 136.803 130.884 1.00 38.71  ? 80  LEU   R C   1 
ATOM   1224 O O   . LEU   B 2 218 ? 142.291 137.025 130.007 1.00 33.73  ? 80  LEU   R O   1 
ATOM   1225 C CB  . LEU   B 2 218 ? 142.505 136.192 133.240 1.00 38.12  ? 80  LEU   R CB  1 
ATOM   1226 C CG  . LEU   B 2 218 ? 141.076 136.702 133.401 1.00 40.03  ? 80  LEU   R CG  1 
ATOM   1227 C CD1 . LEU   B 2 218 ? 140.121 135.790 132.683 1.00 45.60  ? 80  LEU   R CD1 1 
ATOM   1228 C CD2 . LEU   B 2 218 ? 140.712 136.806 134.866 1.00 37.87  ? 80  LEU   R CD2 1 
ATOM   1229 N N   . SER   B 2 219 ? 144.235 137.541 131.012 1.00 46.48  ? 81  SER   R N   1 
ATOM   1230 C CA  . SER   B 2 219 ? 144.492 138.657 130.108 1.00 40.91  ? 81  SER   R CA  1 
ATOM   1231 C C   . SER   B 2 219 ? 144.779 138.186 128.689 1.00 44.60  ? 81  SER   R C   1 
ATOM   1232 O O   . SER   B 2 219 ? 144.403 138.865 127.729 1.00 47.52  ? 81  SER   R O   1 
ATOM   1233 C CB  . SER   B 2 219 ? 145.648 139.507 130.629 1.00 41.25  ? 81  SER   R CB  1 
ATOM   1234 O OG  . SER   B 2 219 ? 145.288 140.144 131.840 1.00 48.52  ? 81  SER   R OG  1 
ATOM   1235 N N   . VAL   B 2 220 ? 145.438 137.036 128.531 1.00 56.63  ? 82  VAL   R N   1 
ATOM   1236 C CA  . VAL   B 2 220 ? 145.635 136.482 127.192 1.00 51.85  ? 82  VAL   R CA  1 
ATOM   1237 C C   . VAL   B 2 220 ? 144.289 136.222 126.526 1.00 48.32  ? 82  VAL   R C   1 
ATOM   1238 O O   . VAL   B 2 220 ? 144.044 136.642 125.386 1.00 64.17  ? 82  VAL   R O   1 
ATOM   1239 C CB  . VAL   B 2 220 ? 146.487 135.201 127.257 1.00 43.31  ? 82  VAL   R CB  1 
ATOM   1240 C CG1 . VAL   B 2 220 ? 146.334 134.398 125.978 1.00 34.30  ? 82  VAL   R CG1 1 
ATOM   1241 C CG2 . VAL   B 2 220 ? 147.942 135.545 127.500 1.00 40.91  ? 82  VAL   R CG2 1 
ATOM   1242 N N   . ALA   B 2 221 ? 143.386 135.542 127.239 1.00 36.19  ? 83  ALA   R N   1 
ATOM   1243 C CA  . ALA   B 2 221 ? 142.072 135.260 126.664 1.00 33.14  ? 83  ALA   R CA  1 
ATOM   1244 C C   . ALA   B 2 221 ? 141.299 136.545 126.382 1.00 42.98  ? 83  ALA   R C   1 
ATOM   1245 O O   . ALA   B 2 221 ? 140.643 136.673 125.337 1.00 49.85  ? 83  ALA   R O   1 
ATOM   1246 C CB  . ALA   B 2 221 ? 141.277 134.348 127.595 1.00 42.66  ? 83  ALA   R CB  1 
ATOM   1247 N N   . ASP   B 2 222 ? 141.367 137.511 127.303 1.00 47.77  ? 84  ASP   R N   1 
ATOM   1248 C CA  . ASP   B 2 222 ? 140.637 138.761 127.123 1.00 42.42  ? 84  ASP   R CA  1 
ATOM   1249 C C   . ASP   B 2 222 ? 141.125 139.517 125.897 1.00 46.20  ? 84  ASP   R C   1 
ATOM   1250 O O   . ASP   B 2 222 ? 140.316 140.026 125.116 1.00 48.86  ? 84  ASP   R O   1 
ATOM   1251 C CB  . ASP   B 2 222 ? 140.766 139.632 128.372 1.00 45.50  ? 84  ASP   R CB  1 
ATOM   1252 C CG  . ASP   B 2 222 ? 139.817 139.214 129.477 1.00 60.88  ? 84  ASP   R CG  1 
ATOM   1253 O OD1 . ASP   B 2 222 ? 138.897 138.417 129.204 1.00 63.23  ? 84  ASP   R OD1 1 
ATOM   1254 O OD2 . ASP   B 2 222 ? 139.990 139.686 130.620 1.00 64.54  ? 84  ASP   R OD2 1 
ATOM   1255 N N   . LEU   B 2 223 ? 142.445 139.607 125.713 1.00 53.52  ? 85  LEU   R N   1 
ATOM   1256 C CA  . LEU   B 2 223 ? 142.983 140.279 124.534 1.00 50.84  ? 85  LEU   R CA  1 
ATOM   1257 C C   . LEU   B 2 223 ? 142.584 139.554 123.259 1.00 42.98  ? 85  LEU   R C   1 
ATOM   1258 O O   . LEU   B 2 223 ? 142.224 140.189 122.257 1.00 48.45  ? 85  LEU   R O   1 
ATOM   1259 C CB  . LEU   B 2 223 ? 144.504 140.375 124.635 1.00 48.38  ? 85  LEU   R CB  1 
ATOM   1260 C CG  . LEU   B 2 223 ? 145.244 140.770 123.359 1.00 48.08  ? 85  LEU   R CG  1 
ATOM   1261 C CD1 . LEU   B 2 223 ? 145.086 142.254 123.094 1.00 51.60  ? 85  LEU   R CD1 1 
ATOM   1262 C CD2 . LEU   B 2 223 ? 146.711 140.397 123.459 1.00 51.31  ? 85  LEU   R CD2 1 
ATOM   1263 N N   . LEU   B 2 224 ? 142.648 138.220 123.278 1.00 42.73  ? 86  LEU   R N   1 
ATOM   1264 C CA  . LEU   B 2 224 ? 142.265 137.450 122.101 1.00 45.16  ? 86  LEU   R CA  1 
ATOM   1265 C C   . LEU   B 2 224 ? 140.822 137.728 121.708 1.00 51.08  ? 86  LEU   R C   1 
ATOM   1266 O O   . LEU   B 2 224 ? 140.495 137.781 120.518 1.00 52.72  ? 86  LEU   R O   1 
ATOM   1267 C CB  . LEU   B 2 224 ? 142.476 135.960 122.361 1.00 50.60  ? 86  LEU   R CB  1 
ATOM   1268 C CG  . LEU   B 2 224 ? 142.753 135.091 121.136 1.00 52.31  ? 86  LEU   R CG  1 
ATOM   1269 C CD1 . LEU   B 2 224 ? 144.122 135.410 120.560 1.00 51.41  ? 86  LEU   R CD1 1 
ATOM   1270 C CD2 . LEU   B 2 224 ? 142.648 133.622 121.501 1.00 53.26  ? 86  LEU   R CD2 1 
ATOM   1271 N N   . PHE   B 2 225 ? 139.939 137.905 122.694 1.00 48.40  ? 87  PHE   R N   1 
ATOM   1272 C CA  . PHE   B 2 225 ? 138.560 138.259 122.362 1.00 38.11  ? 87  PHE   R CA  1 
ATOM   1273 C C   . PHE   B 2 225 ? 138.445 139.703 121.884 1.00 49.33  ? 87  PHE   R C   1 
ATOM   1274 O O   . PHE   B 2 225 ? 137.735 139.985 120.912 1.00 49.59  ? 87  PHE   R O   1 
ATOM   1275 C CB  . PHE   B 2 225 ? 137.643 138.041 123.559 1.00 49.66  ? 87  PHE   R CB  1 
ATOM   1276 C CG  . PHE   B 2 225 ? 136.284 138.653 123.392 1.00 46.26  ? 87  PHE   R CG  1 
ATOM   1277 C CD1 . PHE   B 2 225 ? 135.426 138.204 122.407 1.00 46.43  ? 87  PHE   R CD1 1 
ATOM   1278 C CD2 . PHE   B 2 225 ? 135.868 139.683 124.214 1.00 47.02  ? 87  PHE   R CD2 1 
ATOM   1279 C CE1 . PHE   B 2 225 ? 134.179 138.767 122.250 1.00 45.56  ? 87  PHE   R CE1 1 
ATOM   1280 C CE2 . PHE   B 2 225 ? 134.620 140.249 124.060 1.00 49.11  ? 87  PHE   R CE2 1 
ATOM   1281 C CZ  . PHE   B 2 225 ? 133.775 139.789 123.077 1.00 48.41  ? 87  PHE   R CZ  1 
ATOM   1282 N N   . VAL   B 2 226 ? 139.127 140.631 122.560 1.00 60.48  ? 88  VAL   R N   1 
ATOM   1283 C CA  . VAL   B 2 226 ? 138.933 142.054 122.295 1.00 46.54  ? 88  VAL   R CA  1 
ATOM   1284 C C   . VAL   B 2 226 ? 139.442 142.440 120.912 1.00 48.61  ? 88  VAL   R C   1 
ATOM   1285 O O   . VAL   B 2 226 ? 138.889 143.346 120.278 1.00 53.86  ? 88  VAL   R O   1 
ATOM   1286 C CB  . VAL   B 2 226 ? 139.594 142.892 123.405 1.00 41.54  ? 88  VAL   R CB  1 
ATOM   1287 C CG1 . VAL   B 2 226 ? 139.667 144.347 123.014 1.00 48.69  ? 88  VAL   R CG1 1 
ATOM   1288 C CG2 . VAL   B 2 226 ? 138.806 142.761 124.690 1.00 51.97  ? 88  VAL   R CG2 1 
ATOM   1289 N N   . ILE   B 2 227 ? 140.467 141.757 120.398 1.00 57.23  ? 89  ILE   R N   1 
ATOM   1290 C CA  . ILE   B 2 227 ? 141.016 142.135 119.095 1.00 50.47  ? 89  ILE   R CA  1 
ATOM   1291 C C   . ILE   B 2 227 ? 140.004 141.926 117.970 1.00 51.89  ? 89  ILE   R C   1 
ATOM   1292 O O   . ILE   B 2 227 ? 140.291 142.238 116.810 1.00 66.13  ? 89  ILE   R O   1 
ATOM   1293 C CB  . ILE   B 2 227 ? 142.318 141.376 118.772 1.00 46.42  ? 89  ILE   R CB  1 
ATOM   1294 C CG1 . ILE   B 2 227 ? 142.067 139.872 118.706 1.00 50.84  ? 89  ILE   R CG1 1 
ATOM   1295 C CG2 . ILE   B 2 227 ? 143.410 141.716 119.767 1.00 55.14  ? 89  ILE   R CG2 1 
ATOM   1296 C CD1 . ILE   B 2 227 ? 143.198 139.102 118.068 1.00 55.60  ? 89  ILE   R CD1 1 
ATOM   1297 N N   . THR   B 2 228 ? 138.819 141.400 118.291 1.00 45.80  ? 90  THR   R N   1 
ATOM   1298 C CA  . THR   B 2 228 ? 137.800 141.116 117.286 1.00 52.55  ? 90  THR   R CA  1 
ATOM   1299 C C   . THR   B 2 228 ? 136.538 141.958 117.463 1.00 54.70  ? 90  THR   R C   1 
ATOM   1300 O O   . THR   B 2 228 ? 135.498 141.629 116.887 1.00 59.82  ? 90  THR   R O   1 
ATOM   1301 C CB  . THR   B 2 228 ? 137.436 139.631 117.298 1.00 56.06  ? 90  THR   R CB  1 
ATOM   1302 O OG1 . THR   B 2 228 ? 136.658 139.338 118.463 1.00 62.71  ? 90  THR   R OG1 1 
ATOM   1303 C CG2 . THR   B 2 228 ? 138.691 138.778 117.306 1.00 61.11  ? 90  THR   R CG2 1 
ATOM   1304 N N   . LEU   B 2 229 ? 136.601 143.030 118.248 1.00 48.12  ? 91  LEU   R N   1 
ATOM   1305 C CA  . LEU   B 2 229 ? 135.450 143.902 118.478 1.00 42.06  ? 91  LEU   R CA  1 
ATOM   1306 C C   . LEU   B 2 229 ? 135.109 144.823 117.302 1.00 50.96  ? 91  LEU   R C   1 
ATOM   1307 O O   . LEU   B 2 229 ? 133.931 145.169 117.131 1.00 62.23  ? 91  LEU   R O   1 
ATOM   1308 C CB  . LEU   B 2 229 ? 135.666 144.730 119.744 1.00 44.95  ? 91  LEU   R CB  1 
ATOM   1309 C CG  . LEU   B 2 229 ? 135.136 144.069 121.019 1.00 47.11  ? 91  LEU   R CG  1 
ATOM   1310 C CD1 . LEU   B 2 229 ? 135.161 145.030 122.185 1.00 54.61  ? 91  LEU   R CD1 1 
ATOM   1311 C CD2 . LEU   B 2 229 ? 133.732 143.540 120.802 1.00 48.92  ? 91  LEU   R CD2 1 
ATOM   1312 N N   . PRO   B 2 230 ? 136.081 145.278 116.494 1.00 50.49  ? 92  PRO   R N   1 
ATOM   1313 C CA  . PRO   B 2 230 ? 135.708 146.048 115.295 1.00 47.31  ? 92  PRO   R CA  1 
ATOM   1314 C C   . PRO   B 2 230 ? 134.729 145.330 114.382 1.00 49.51  ? 92  PRO   R C   1 
ATOM   1315 O O   . PRO   B 2 230 ? 133.873 145.981 113.770 1.00 57.62  ? 92  PRO   R O   1 
ATOM   1316 C CB  . PRO   B 2 230 ? 137.056 146.278 114.607 1.00 50.26  ? 92  PRO   R CB  1 
ATOM   1317 C CG  . PRO   B 2 230 ? 138.013 146.351 115.715 1.00 56.83  ? 92  PRO   R CG  1 
ATOM   1318 C CD  . PRO   B 2 230 ? 137.526 145.397 116.769 1.00 54.40  ? 92  PRO   R CD  1 
ATOM   1319 N N   . PHE   B 2 231 ? 134.834 144.005 114.268 1.00 51.63  ? 93  PHE   R N   1 
ATOM   1320 C CA  . PHE   B 2 231 ? 133.846 143.254 113.502 1.00 55.58  ? 93  PHE   R CA  1 
ATOM   1321 C C   . PHE   B 2 231 ? 132.457 143.403 114.107 1.00 63.06  ? 93  PHE   R C   1 
ATOM   1322 O O   . PHE   B 2 231 ? 131.471 143.580 113.382 1.00 61.31  ? 93  PHE   R O   1 
ATOM   1323 C CB  . PHE   B 2 231 ? 134.247 141.781 113.429 1.00 58.30  ? 93  PHE   R CB  1 
ATOM   1324 C CG  . PHE   B 2 231 ? 135.528 141.538 112.685 1.00 58.56  ? 93  PHE   R CG  1 
ATOM   1325 C CD1 . PHE   B 2 231 ? 135.527 141.383 111.312 1.00 58.44  ? 93  PHE   R CD1 1 
ATOM   1326 C CD2 . PHE   B 2 231 ? 136.731 141.464 113.360 1.00 64.44  ? 93  PHE   R CD2 1 
ATOM   1327 C CE1 . PHE   B 2 231 ? 136.702 141.159 110.628 1.00 63.35  ? 93  PHE   R CE1 1 
ATOM   1328 C CE2 . PHE   B 2 231 ? 137.909 141.241 112.680 1.00 60.85  ? 93  PHE   R CE2 1 
ATOM   1329 C CZ  . PHE   B 2 231 ? 137.894 141.089 111.313 1.00 61.57  ? 93  PHE   R CZ  1 
ATOM   1330 N N   . TRP   B 2 232 ? 132.362 143.344 115.438 1.00 62.20  ? 94  TRP   R N   1 
ATOM   1331 C CA  . TRP   B 2 232 ? 131.080 143.553 116.103 1.00 54.29  ? 94  TRP   R CA  1 
ATOM   1332 C C   . TRP   B 2 232 ? 130.526 144.938 115.805 1.00 61.18  ? 94  TRP   R C   1 
ATOM   1333 O O   . TRP   B 2 232 ? 129.334 145.090 115.513 1.00 70.21  ? 94  TRP   R O   1 
ATOM   1334 C CB  . TRP   B 2 232 ? 131.231 143.374 117.612 1.00 57.86  ? 94  TRP   R CB  1 
ATOM   1335 C CG  . TRP   B 2 232 ? 131.456 141.972 118.055 1.00 62.92  ? 94  TRP   R CG  1 
ATOM   1336 C CD1 . TRP   B 2 232 ? 132.541 141.193 117.792 1.00 60.18  ? 94  TRP   R CD1 1 
ATOM   1337 C CD2 . TRP   B 2 232 ? 130.577 141.180 118.857 1.00 64.47  ? 94  TRP   R CD2 1 
ATOM   1338 N NE1 . TRP   B 2 232 ? 132.391 139.962 118.377 1.00 61.96  ? 94  TRP   R NE1 1 
ATOM   1339 C CE2 . TRP   B 2 232 ? 131.191 139.928 119.036 1.00 62.59  ? 94  TRP   R CE2 1 
ATOM   1340 C CE3 . TRP   B 2 232 ? 129.326 141.406 119.437 1.00 64.04  ? 94  TRP   R CE3 1 
ATOM   1341 C CZ2 . TRP   B 2 232 ? 130.598 138.906 119.770 1.00 63.56  ? 94  TRP   R CZ2 1 
ATOM   1342 C CZ3 . TRP   B 2 232 ? 128.740 140.391 120.163 1.00 63.45  ? 94  TRP   R CZ3 1 
ATOM   1343 C CH2 . TRP   B 2 232 ? 129.375 139.158 120.325 1.00 67.42  ? 94  TRP   R CH2 1 
ATOM   1344 N N   . ALA   B 2 233 ? 131.378 145.962 115.883 1.00 63.31  ? 95  ALA   R N   1 
ATOM   1345 C CA  . ALA   B 2 233 ? 130.920 147.326 115.636 1.00 57.37  ? 95  ALA   R CA  1 
ATOM   1346 C C   . ALA   B 2 233 ? 130.421 147.490 114.206 1.00 57.94  ? 95  ALA   R C   1 
ATOM   1347 O O   . ALA   B 2 233 ? 129.356 148.072 113.969 1.00 62.45  ? 95  ALA   R O   1 
ATOM   1348 C CB  . ALA   B 2 233 ? 132.045 148.318 115.932 1.00 56.84  ? 95  ALA   R CB  1 
ATOM   1349 N N   . VAL   B 2 234 ? 131.176 146.969 113.236 1.00 64.60  ? 96  VAL   R N   1 
ATOM   1350 C CA  . VAL   B 2 234 ? 130.780 147.096 111.836 1.00 63.85  ? 96  VAL   R CA  1 
ATOM   1351 C C   . VAL   B 2 234 ? 129.487 146.334 111.574 1.00 68.15  ? 96  VAL   R C   1 
ATOM   1352 O O   . VAL   B 2 234 ? 128.620 146.796 110.824 1.00 74.35  ? 96  VAL   R O   1 
ATOM   1353 C CB  . VAL   B 2 234 ? 131.916 146.626 110.910 1.00 63.12  ? 96  VAL   R CB  1 
ATOM   1354 C CG1 . VAL   B 2 234 ? 131.432 146.539 109.476 1.00 64.20  ? 96  VAL   R CG1 1 
ATOM   1355 C CG2 . VAL   B 2 234 ? 133.100 147.572 111.009 1.00 65.30  ? 96  VAL   R CG2 1 
ATOM   1356 N N   . ASP   B 2 235 ? 129.332 145.159 112.189 1.00 74.38  ? 97  ASP   R N   1 
ATOM   1357 C CA  . ASP   B 2 235 ? 128.090 144.411 112.031 1.00 78.20  ? 97  ASP   R CA  1 
ATOM   1358 C C   . ASP   B 2 235 ? 126.909 145.170 112.622 1.00 77.70  ? 97  ASP   R C   1 
ATOM   1359 O O   . ASP   B 2 235 ? 125.819 145.186 112.040 1.00 76.81  ? 97  ASP   R O   1 
ATOM   1360 C CB  . ASP   B 2 235 ? 128.219 143.035 112.682 1.00 77.41  ? 97  ASP   R CB  1 
ATOM   1361 C CG  . ASP   B 2 235 ? 126.957 142.209 112.554 1.00 79.44  ? 97  ASP   R CG  1 
ATOM   1362 O OD1 . ASP   B 2 235 ? 126.390 142.157 111.444 1.00 80.72  ? 97  ASP   R OD1 1 
ATOM   1363 O OD2 . ASP   B 2 235 ? 126.529 141.614 113.564 1.00 73.09  ? 97  ASP   R OD2 1 
ATOM   1364 N N   . ALA   B 2 236 ? 127.106 145.804 113.779 1.00 69.69  ? 98  ALA   R N   1 
ATOM   1365 C CA  . ALA   B 2 236 ? 126.006 146.509 114.428 1.00 61.07  ? 98  ALA   R CA  1 
ATOM   1366 C C   . ALA   B 2 236 ? 125.644 147.796 113.699 1.00 64.27  ? 98  ALA   R C   1 
ATOM   1367 O O   . ALA   B 2 236 ? 124.485 148.220 113.743 1.00 71.51  ? 98  ALA   R O   1 
ATOM   1368 C CB  . ALA   B 2 236 ? 126.357 146.808 115.883 1.00 63.11  ? 98  ALA   R CB  1 
ATOM   1369 N N   . VAL   B 2 237 ? 126.606 148.430 113.029 1.00 74.15  ? 99  VAL   R N   1 
ATOM   1370 C CA  . VAL   B 2 237 ? 126.320 149.694 112.354 1.00 71.79  ? 99  VAL   R CA  1 
ATOM   1371 C C   . VAL   B 2 237 ? 125.640 149.455 111.014 1.00 71.40  ? 99  VAL   R C   1 
ATOM   1372 O O   . VAL   B 2 237 ? 124.485 149.842 110.807 1.00 71.57  ? 99  VAL   R O   1 
ATOM   1373 C CB  . VAL   B 2 237 ? 127.606 150.522 112.176 1.00 74.97  ? 99  VAL   R CB  1 
ATOM   1374 C CG1 . VAL   B 2 237 ? 127.329 151.734 111.306 1.00 75.94  ? 99  VAL   R CG1 1 
ATOM   1375 C CG2 . VAL   B 2 237 ? 128.139 150.965 113.514 1.00 76.05  ? 99  VAL   R CG2 1 
ATOM   1376 N N   . ALA   B 2 238 ? 126.343 148.813 110.080 1.00 84.11  ? 100 ALA   R N   1 
ATOM   1377 C CA  . ALA   B 2 238 ? 125.863 148.735 108.705 1.00 87.17  ? 100 ALA   R CA  1 
ATOM   1378 C C   . ALA   B 2 238 ? 125.572 147.312 108.248 1.00 90.46  ? 100 ALA   R C   1 
ATOM   1379 O O   . ALA   B 2 238 ? 124.426 147.012 107.897 1.00 93.19  ? 100 ALA   R O   1 
ATOM   1380 C CB  . ALA   B 2 238 ? 126.883 149.396 107.770 1.00 86.44  ? 100 ALA   R CB  1 
ATOM   1381 N N   . ASN   B 2 239 ? 126.555 146.424 108.257 1.00 95.71  ? 101 ASN   R N   1 
ATOM   1382 C CA  . ASN   B 2 239 ? 126.437 145.152 107.549 1.00 95.06  ? 101 ASN   R CA  1 
ATOM   1383 C C   . ASN   B 2 239 ? 127.636 144.281 107.911 1.00 96.45  ? 101 ASN   R C   1 
ATOM   1384 O O   . ASN   B 2 239 ? 128.448 144.638 108.774 1.00 98.50  ? 101 ASN   R O   1 
ATOM   1385 C CB  . ASN   B 2 239 ? 126.344 145.381 106.040 1.00 96.28  ? 101 ASN   R CB  1 
ATOM   1386 C CG  . ASN   B 2 239 ? 125.413 144.411 105.357 1.00 99.78  ? 101 ASN   R CG  1 
ATOM   1387 O OD1 . ASN   B 2 239 ? 125.073 143.366 105.908 1.00 104.45 ? 101 ASN   R OD1 1 
ATOM   1388 N ND2 . ASN   B 2 239 ? 125.002 144.746 104.141 1.00 97.21  ? 101 ASN   R ND2 1 
ATOM   1389 N N   . TRP   B 2 240 ? 127.745 143.132 107.245 1.00 87.36  ? 102 TRP   R N   1 
ATOM   1390 C CA  . TRP   B 2 240 ? 128.871 142.217 107.399 1.00 85.21  ? 102 TRP   R CA  1 
ATOM   1391 C C   . TRP   B 2 240 ? 129.377 141.854 106.009 1.00 87.92  ? 102 TRP   R C   1 
ATOM   1392 O O   . TRP   B 2 240 ? 128.737 141.072 105.299 1.00 88.05  ? 102 TRP   R O   1 
ATOM   1393 C CB  . TRP   B 2 240 ? 128.463 140.966 108.177 1.00 81.47  ? 102 TRP   R CB  1 
ATOM   1394 C CG  . TRP   B 2 240 ? 129.594 140.019 108.441 1.00 80.54  ? 102 TRP   R CG  1 
ATOM   1395 C CD1 . TRP   B 2 240 ? 130.075 139.064 107.598 1.00 79.63  ? 102 TRP   R CD1 1 
ATOM   1396 C CD2 . TRP   B 2 240 ? 130.382 139.935 109.633 1.00 83.71  ? 102 TRP   R CD2 1 
ATOM   1397 N NE1 . TRP   B 2 240 ? 131.117 138.393 108.187 1.00 79.15  ? 102 TRP   R NE1 1 
ATOM   1398 C CE2 . TRP   B 2 240 ? 131.325 138.909 109.438 1.00 84.35  ? 102 TRP   R CE2 1 
ATOM   1399 C CE3 . TRP   B 2 240 ? 130.384 140.630 110.845 1.00 83.82  ? 102 TRP   R CE3 1 
ATOM   1400 C CZ2 . TRP   B 2 240 ? 132.259 138.561 110.409 1.00 84.91  ? 102 TRP   R CZ2 1 
ATOM   1401 C CZ3 . TRP   B 2 240 ? 131.311 140.281 111.807 1.00 80.86  ? 102 TRP   R CZ3 1 
ATOM   1402 C CH2 . TRP   B 2 240 ? 132.236 139.257 111.583 1.00 78.10  ? 102 TRP   R CH2 1 
ATOM   1403 N N   . TYR   B 2 241 ? 130.521 142.421 105.619 1.00 95.82  ? 103 TYR   R N   1 
ATOM   1404 C CA  . TYR   B 2 241 ? 131.124 142.163 104.317 1.00 93.24  ? 103 TYR   R CA  1 
ATOM   1405 C C   . TYR   B 2 241 ? 132.393 141.323 104.415 1.00 94.86  ? 103 TYR   R C   1 
ATOM   1406 O O   . TYR   B 2 241 ? 133.209 141.336 103.488 1.00 97.58  ? 103 TYR   R O   1 
ATOM   1407 C CB  . TYR   B 2 241 ? 131.446 143.475 103.600 1.00 94.99  ? 103 TYR   R CB  1 
ATOM   1408 C CG  . TYR   B 2 241 ? 130.369 144.534 103.648 1.00 95.16  ? 103 TYR   R CG  1 
ATOM   1409 C CD1 . TYR   B 2 241 ? 129.139 144.334 103.039 1.00 94.45  ? 103 TYR   R CD1 1 
ATOM   1410 C CD2 . TYR   B 2 241 ? 130.598 145.749 104.280 1.00 94.86  ? 103 TYR   R CD2 1 
ATOM   1411 C CE1 . TYR   B 2 241 ? 128.161 145.308 103.072 1.00 94.26  ? 103 TYR   R CE1 1 
ATOM   1412 C CE2 . TYR   B 2 241 ? 129.628 146.728 104.320 1.00 97.02  ? 103 TYR   R CE2 1 
ATOM   1413 C CZ  . TYR   B 2 241 ? 128.413 146.504 103.713 1.00 96.92  ? 103 TYR   R CZ  1 
ATOM   1414 O OH  . TYR   B 2 241 ? 127.442 147.478 103.752 1.00 98.90  ? 103 TYR   R OH  1 
ATOM   1415 N N   . PHE   B 2 242 ? 132.582 140.594 105.513 1.00 84.74  ? 104 PHE   R N   1 
ATOM   1416 C CA  . PHE   B 2 242 ? 133.884 139.998 105.786 1.00 83.47  ? 104 PHE   R CA  1 
ATOM   1417 C C   . PHE   B 2 242 ? 134.002 138.562 105.284 1.00 84.63  ? 104 PHE   R C   1 
ATOM   1418 O O   . PHE   B 2 242 ? 134.988 138.219 104.626 1.00 88.68  ? 104 PHE   R O   1 
ATOM   1419 C CB  . PHE   B 2 242 ? 134.177 140.082 107.283 1.00 82.31  ? 104 PHE   R CB  1 
ATOM   1420 C CG  . PHE   B 2 242 ? 134.125 141.482 107.821 1.00 83.17  ? 104 PHE   R CG  1 
ATOM   1421 C CD1 . PHE   B 2 242 ? 135.195 142.340 107.650 1.00 81.20  ? 104 PHE   R CD1 1 
ATOM   1422 C CD2 . PHE   B 2 242 ? 133.001 141.943 108.481 1.00 83.85  ? 104 PHE   R CD2 1 
ATOM   1423 C CE1 . PHE   B 2 242 ? 135.149 143.630 108.137 1.00 82.17  ? 104 PHE   R CE1 1 
ATOM   1424 C CE2 . PHE   B 2 242 ? 132.949 143.231 108.970 1.00 80.87  ? 104 PHE   R CE2 1 
ATOM   1425 C CZ  . PHE   B 2 242 ? 134.024 144.075 108.798 1.00 81.96  ? 104 PHE   R CZ  1 
ATOM   1426 N N   . GLY   B 2 243 ? 133.028 137.710 105.578 1.00 86.24  ? 105 GLY   R N   1 
ATOM   1427 C CA  . GLY   B 2 243 ? 132.998 136.374 105.018 1.00 86.42  ? 105 GLY   R CA  1 
ATOM   1428 C C   . GLY   B 2 243 ? 132.707 135.309 106.057 1.00 94.65  ? 105 GLY   R C   1 
ATOM   1429 O O   . GLY   B 2 243 ? 132.755 135.533 107.266 1.00 97.74  ? 105 GLY   R O   1 
ATOM   1430 N N   . ASN   B 2 244 ? 132.410 134.114 105.538 1.00 87.11  ? 106 ASN   R N   1 
ATOM   1431 C CA  . ASN   B 2 244 ? 132.024 132.986 106.380 1.00 84.44  ? 106 ASN   R CA  1 
ATOM   1432 C C   . ASN   B 2 244 ? 133.166 132.542 107.287 1.00 78.91  ? 106 ASN   R C   1 
ATOM   1433 O O   . ASN   B 2 244 ? 132.944 132.209 108.459 1.00 80.06  ? 106 ASN   R O   1 
ATOM   1434 C CB  . ASN   B 2 244 ? 131.557 131.830 105.498 1.00 78.96  ? 106 ASN   R CB  1 
ATOM   1435 C CG  . ASN   B 2 244 ? 130.663 130.864 106.233 1.00 85.60  ? 106 ASN   R CG  1 
ATOM   1436 O OD1 . ASN   B 2 244 ? 130.405 131.025 107.424 1.00 91.05  ? 106 ASN   R OD1 1 
ATOM   1437 N ND2 . ASN   B 2 244 ? 130.177 129.851 105.526 1.00 88.06  ? 106 ASN   R ND2 1 
ATOM   1438 N N   . PHE   B 2 245 ? 134.391 132.518 106.759 1.00 71.28  ? 107 PHE   R N   1 
ATOM   1439 C CA  . PHE   B 2 245 ? 135.533 132.108 107.567 1.00 74.75  ? 107 PHE   R CA  1 
ATOM   1440 C C   . PHE   B 2 245 ? 135.745 133.054 108.742 1.00 82.48  ? 107 PHE   R C   1 
ATOM   1441 O O   . PHE   B 2 245 ? 135.993 132.611 109.869 1.00 88.86  ? 107 PHE   R O   1 
ATOM   1442 C CB  . PHE   B 2 245 ? 136.788 132.034 106.699 1.00 75.19  ? 107 PHE   R CB  1 
ATOM   1443 C CG  . PHE   B 2 245 ? 138.055 131.866 107.481 1.00 79.95  ? 107 PHE   R CG  1 
ATOM   1444 C CD1 . PHE   B 2 245 ? 138.381 130.646 108.041 1.00 79.92  ? 107 PHE   R CD1 1 
ATOM   1445 C CD2 . PHE   B 2 245 ? 138.923 132.930 107.654 1.00 82.94  ? 107 PHE   R CD2 1 
ATOM   1446 C CE1 . PHE   B 2 245 ? 139.547 130.490 108.763 1.00 80.03  ? 107 PHE   R CE1 1 
ATOM   1447 C CE2 . PHE   B 2 245 ? 140.090 132.781 108.375 1.00 83.44  ? 107 PHE   R CE2 1 
ATOM   1448 C CZ  . PHE   B 2 245 ? 140.403 131.559 108.929 1.00 82.46  ? 107 PHE   R CZ  1 
ATOM   1449 N N   . LEU   B 2 246 ? 135.639 134.362 108.501 1.00 74.33  ? 108 LEU   R N   1 
ATOM   1450 C CA  . LEU   B 2 246 ? 135.794 135.321 109.589 1.00 72.87  ? 108 LEU   R CA  1 
ATOM   1451 C C   . LEU   B 2 246 ? 134.634 135.247 110.572 1.00 74.41  ? 108 LEU   R C   1 
ATOM   1452 O O   . LEU   B 2 246 ? 134.836 135.429 111.779 1.00 79.26  ? 108 LEU   R O   1 
ATOM   1453 C CB  . LEU   B 2 246 ? 135.938 136.732 109.025 1.00 71.46  ? 108 LEU   R CB  1 
ATOM   1454 C CG  . LEU   B 2 246 ? 137.355 137.058 108.552 1.00 75.56  ? 108 LEU   R CG  1 
ATOM   1455 C CD1 . LEU   B 2 246 ? 137.439 138.475 108.014 1.00 77.58  ? 108 LEU   R CD1 1 
ATOM   1456 C CD2 . LEU   B 2 246 ? 138.351 136.850 109.679 1.00 73.79  ? 108 LEU   R CD2 1 
ATOM   1457 N N   . CYS   B 2 247 ? 133.420 134.983 110.081 1.00 66.52  ? 109 CYS   R N   1 
ATOM   1458 C CA  . CYS   B 2 247 ? 132.291 134.744 110.976 1.00 66.86  ? 109 CYS   R CA  1 
ATOM   1459 C C   . CYS   B 2 247 ? 132.596 133.600 111.938 1.00 72.42  ? 109 CYS   R C   1 
ATOM   1460 O O   . CYS   B 2 247 ? 132.452 133.734 113.164 1.00 75.96  ? 109 CYS   R O   1 
ATOM   1461 C CB  . CYS   B 2 247 ? 131.043 134.442 110.142 1.00 62.76  ? 109 CYS   R CB  1 
ATOM   1462 S SG  . CYS   B 2 247 ? 129.441 134.552 110.982 1.00 86.68  ? 109 CYS   R SG  1 
ATOM   1463 N N   . LYS   B 2 248 ? 133.055 132.471 111.392 1.00 63.37  ? 110 LYS   R N   1 
ATOM   1464 C CA  . LYS   B 2 248 ? 133.392 131.323 112.227 1.00 55.60  ? 110 LYS   R CA  1 
ATOM   1465 C C   . LYS   B 2 248 ? 134.512 131.658 113.202 1.00 56.04  ? 110 LYS   R C   1 
ATOM   1466 O O   . LYS   B 2 248 ? 134.463 131.266 114.374 1.00 64.63  ? 110 LYS   R O   1 
ATOM   1467 C CB  . LYS   B 2 248 ? 133.786 130.135 111.351 1.00 55.46  ? 110 LYS   R CB  1 
ATOM   1468 C CG  . LYS   B 2 248 ? 132.626 129.471 110.635 1.00 57.11  ? 110 LYS   R CG  1 
ATOM   1469 C CD  . LYS   B 2 248 ? 133.096 128.289 109.810 1.00 55.48  ? 110 LYS   R CD  1 
ATOM   1470 C CE  . LYS   B 2 248 ? 132.006 127.801 108.877 1.00 55.37  ? 110 LYS   R CE  1 
ATOM   1471 N NZ  . LYS   B 2 248 ? 130.820 127.308 109.622 1.00 58.08  ? 110 LYS   R NZ  1 
ATOM   1472 N N   . ALA   B 2 249 ? 135.536 132.375 112.734 1.00 45.98  ? 111 ALA   R N   1 
ATOM   1473 C CA  . ALA   B 2 249 ? 136.675 132.684 113.592 1.00 49.40  ? 111 ALA   R CA  1 
ATOM   1474 C C   . ALA   B 2 249 ? 136.268 133.559 114.771 1.00 58.37  ? 111 ALA   R C   1 
ATOM   1475 O O   . ALA   B 2 249 ? 136.671 133.301 115.914 1.00 62.69  ? 111 ALA   R O   1 
ATOM   1476 C CB  . ALA   B 2 249 ? 137.775 133.361 112.776 1.00 53.59  ? 111 ALA   R CB  1 
ATOM   1477 N N   . VAL   B 2 250 ? 135.467 134.598 114.521 1.00 61.53  ? 112 VAL   R N   1 
ATOM   1478 C CA  . VAL   B 2 250 ? 135.076 135.482 115.614 1.00 59.65  ? 112 VAL   R CA  1 
ATOM   1479 C C   . VAL   B 2 250 ? 134.153 134.754 116.585 1.00 58.75  ? 112 VAL   R C   1 
ATOM   1480 O O   . VAL   B 2 250 ? 134.242 134.951 117.803 1.00 62.78  ? 112 VAL   R O   1 
ATOM   1481 C CB  . VAL   B 2 250 ? 134.448 136.787 115.084 1.00 51.90  ? 112 VAL   R CB  1 
ATOM   1482 C CG1 . VAL   B 2 250 ? 135.465 137.573 114.275 1.00 57.36  ? 112 VAL   R CG1 1 
ATOM   1483 C CG2 . VAL   B 2 250 ? 133.200 136.518 114.269 1.00 56.52  ? 112 VAL   R CG2 1 
ATOM   1484 N N   . HIS   B 2 251 ? 133.272 133.883 116.076 1.00 52.26  ? 113 HIS   R N   1 
ATOM   1485 C CA  . HIS   B 2 251 ? 132.433 133.099 116.981 1.00 49.14  ? 113 HIS   R CA  1 
ATOM   1486 C C   . HIS   B 2 251 ? 133.275 132.188 117.871 1.00 54.46  ? 113 HIS   R C   1 
ATOM   1487 O O   . HIS   B 2 251 ? 133.037 132.092 119.085 1.00 55.88  ? 113 HIS   R O   1 
ATOM   1488 C CB  . HIS   B 2 251 ? 131.427 132.276 116.182 1.00 51.07  ? 113 HIS   R CB  1 
ATOM   1489 C CG  . HIS   B 2 251 ? 130.182 133.022 115.824 1.00 54.52  ? 113 HIS   R CG  1 
ATOM   1490 N ND1 . HIS   B 2 251 ? 130.019 133.657 114.612 1.00 56.98  ? 113 HIS   R ND1 1 
ATOM   1491 C CD2 . HIS   B 2 251 ? 129.037 133.229 116.514 1.00 58.97  ? 113 HIS   R CD2 1 
ATOM   1492 C CE1 . HIS   B 2 251 ? 128.827 134.224 114.572 1.00 53.37  ? 113 HIS   R CE1 1 
ATOM   1493 N NE2 . HIS   B 2 251 ? 128.210 133.978 115.713 1.00 57.39  ? 113 HIS   R NE2 1 
ATOM   1494 N N   . VAL   B 2 252 ? 134.268 131.515 117.284 1.00 57.89  ? 114 VAL   R N   1 
ATOM   1495 C CA  . VAL   B 2 252 ? 135.119 130.606 118.047 1.00 52.42  ? 114 VAL   R CA  1 
ATOM   1496 C C   . VAL   B 2 252 ? 135.882 131.367 119.122 1.00 50.71  ? 114 VAL   R C   1 
ATOM   1497 O O   . VAL   B 2 252 ? 135.977 130.920 120.274 1.00 60.87  ? 114 VAL   R O   1 
ATOM   1498 C CB  . VAL   B 2 252 ? 136.072 129.854 117.098 1.00 46.40  ? 114 VAL   R CB  1 
ATOM   1499 C CG1 . VAL   B 2 252 ? 137.260 129.293 117.858 1.00 50.18  ? 114 VAL   R CG1 1 
ATOM   1500 C CG2 . VAL   B 2 252 ? 135.331 128.751 116.374 1.00 45.53  ? 114 VAL   R CG2 1 
ATOM   1501 N N   . ILE   B 2 253 ? 136.436 132.527 118.764 1.00 37.66  ? 115 ILE   R N   1 
ATOM   1502 C CA  . ILE   B 2 253 ? 137.169 133.331 119.737 1.00 41.52  ? 115 ILE   R CA  1 
ATOM   1503 C C   . ILE   B 2 253 ? 136.248 133.770 120.868 1.00 44.51  ? 115 ILE   R C   1 
ATOM   1504 O O   . ILE   B 2 253 ? 136.622 133.729 122.051 1.00 47.78  ? 115 ILE   R O   1 
ATOM   1505 C CB  . ILE   B 2 253 ? 137.826 134.533 119.039 1.00 47.98  ? 115 ILE   R CB  1 
ATOM   1506 C CG1 . ILE   B 2 253 ? 138.977 134.065 118.148 1.00 47.24  ? 115 ILE   R CG1 1 
ATOM   1507 C CG2 . ILE   B 2 253 ? 138.319 135.531 120.057 1.00 48.90  ? 115 ILE   R CG2 1 
ATOM   1508 C CD1 . ILE   B 2 253 ? 139.556 135.152 117.281 1.00 45.47  ? 115 ILE   R CD1 1 
ATOM   1509 N N   . TYR   B 2 254 ? 135.030 134.195 120.522 1.00 46.96  ? 116 TYR   R N   1 
ATOM   1510 C CA  . TYR   B 2 254 ? 134.064 134.615 121.531 1.00 37.53  ? 116 TYR   R CA  1 
ATOM   1511 C C   . TYR   B 2 254 ? 133.793 133.500 122.530 1.00 49.61  ? 116 TYR   R C   1 
ATOM   1512 O O   . TYR   B 2 254 ? 133.858 133.714 123.746 1.00 58.29  ? 116 TYR   R O   1 
ATOM   1513 C CB  . TYR   B 2 254 ? 132.773 135.060 120.842 1.00 37.96  ? 116 TYR   R CB  1 
ATOM   1514 C CG  . TYR   B 2 254 ? 131.664 135.492 121.771 1.00 43.83  ? 116 TYR   R CG  1 
ATOM   1515 C CD1 . TYR   B 2 254 ? 131.917 136.319 122.854 1.00 46.14  ? 116 TYR   R CD1 1 
ATOM   1516 C CD2 . TYR   B 2 254 ? 130.355 135.088 121.551 1.00 44.49  ? 116 TYR   R CD2 1 
ATOM   1517 C CE1 . TYR   B 2 254 ? 130.903 136.720 123.699 1.00 46.66  ? 116 TYR   R CE1 1 
ATOM   1518 C CE2 . TYR   B 2 254 ? 129.336 135.483 122.389 1.00 41.97  ? 116 TYR   R CE2 1 
ATOM   1519 C CZ  . TYR   B 2 254 ? 129.615 136.298 123.461 1.00 45.62  ? 116 TYR   R CZ  1 
ATOM   1520 O OH  . TYR   B 2 254 ? 128.600 136.694 124.298 1.00 53.74  ? 116 TYR   R OH  1 
ATOM   1521 N N   . THR   B 2 255 ? 133.504 132.293 122.034 1.00 46.30  ? 117 THR   R N   1 
ATOM   1522 C CA  . THR   B 2 255 ? 133.205 131.179 122.935 1.00 39.52  ? 117 THR   R CA  1 
ATOM   1523 C C   . THR   B 2 255 ? 134.405 130.819 123.805 1.00 30.67  ? 117 THR   R C   1 
ATOM   1524 O O   . THR   B 2 255 ? 134.261 130.585 125.017 1.00 38.53  ? 117 THR   R O   1 
ATOM   1525 C CB  . THR   B 2 255 ? 132.753 129.960 122.135 1.00 40.44  ? 117 THR   R CB  1 
ATOM   1526 O OG1 . THR   B 2 255 ? 131.468 130.215 121.557 1.00 44.44  ? 117 THR   R OG1 1 
ATOM   1527 C CG2 . THR   B 2 255 ? 132.661 128.742 123.029 1.00 43.14  ? 117 THR   R CG2 1 
ATOM   1528 N N   . VAL   B 2 256 ? 135.597 130.765 123.203 1.00 43.05  ? 118 VAL   R N   1 
ATOM   1529 C CA  . VAL   B 2 256 ? 136.792 130.397 123.957 1.00 45.63  ? 118 VAL   R CA  1 
ATOM   1530 C C   . VAL   B 2 256 ? 137.004 131.364 125.113 1.00 47.45  ? 118 VAL   R C   1 
ATOM   1531 O O   . VAL   B 2 256 ? 137.196 130.949 126.262 1.00 53.55  ? 118 VAL   R O   1 
ATOM   1532 C CB  . VAL   B 2 256 ? 138.023 130.350 123.034 1.00 39.06  ? 118 VAL   R CB  1 
ATOM   1533 C CG1 . VAL   B 2 256 ? 139.298 130.455 123.848 1.00 40.06  ? 118 VAL   R CG1 1 
ATOM   1534 C CG2 . VAL   B 2 256 ? 138.025 129.079 122.220 1.00 38.34  ? 118 VAL   R CG2 1 
ATOM   1535 N N   . ASN   B 2 257 ? 136.963 132.668 124.829 1.00 40.35  ? 119 ASN   R N   1 
ATOM   1536 C CA  . ASN   B 2 257 ? 137.148 133.647 125.896 1.00 42.69  ? 119 ASN   R CA  1 
ATOM   1537 C C   . ASN   B 2 257 ? 136.046 133.537 126.939 1.00 45.20  ? 119 ASN   R C   1 
ATOM   1538 O O   . ASN   B 2 257 ? 136.318 133.550 128.149 1.00 52.56  ? 119 ASN   R O   1 
ATOM   1539 C CB  . ASN   B 2 257 ? 137.188 135.057 125.315 1.00 38.61  ? 119 ASN   R CB  1 
ATOM   1540 C CG  . ASN   B 2 257 ? 136.930 136.123 126.357 1.00 41.00  ? 119 ASN   R CG  1 
ATOM   1541 O OD1 . ASN   B 2 257 ? 135.793 136.533 126.576 1.00 45.07  ? 119 ASN   R OD1 1 
ATOM   1542 N ND2 . ASN   B 2 257 ? 137.990 136.581 127.003 1.00 49.15  ? 119 ASN   R ND2 1 
ATOM   1543 N N   . LEU   B 2 258 ? 134.799 133.389 126.485 1.00 39.12  ? 120 LEU   R N   1 
ATOM   1544 C CA  . LEU   B 2 258 ? 133.658 133.383 127.390 1.00 35.32  ? 120 LEU   R CA  1 
ATOM   1545 C C   . LEU   B 2 258 ? 133.771 132.274 128.424 1.00 43.98  ? 120 LEU   R C   1 
ATOM   1546 O O   . LEU   B 2 258 ? 133.456 132.482 129.601 1.00 47.47  ? 120 LEU   R O   1 
ATOM   1547 C CB  . LEU   B 2 258 ? 132.372 133.239 126.578 1.00 33.39  ? 120 LEU   R CB  1 
ATOM   1548 C CG  . LEU   B 2 258 ? 131.028 133.289 127.292 1.00 46.61  ? 120 LEU   R CG  1 
ATOM   1549 C CD1 . LEU   B 2 258 ? 130.033 134.064 126.457 1.00 40.56  ? 120 LEU   R CD1 1 
ATOM   1550 C CD2 . LEU   B 2 258 ? 130.526 131.882 127.539 1.00 50.01  ? 120 LEU   R CD2 1 
ATOM   1551 N N   . TYR   B 2 259 ? 134.216 131.087 128.009 1.00 48.58  ? 121 TYR   R N   1 
ATOM   1552 C CA  . TYR   B 2 259 ? 134.316 129.998 128.978 1.00 42.97  ? 121 TYR   R CA  1 
ATOM   1553 C C   . TYR   B 2 259 ? 135.625 130.046 129.764 1.00 42.26  ? 121 TYR   R C   1 
ATOM   1554 O O   . TYR   B 2 259 ? 135.638 129.789 130.981 1.00 52.25  ? 121 TYR   R O   1 
ATOM   1555 C CB  . TYR   B 2 259 ? 134.159 128.656 128.270 1.00 44.75  ? 121 TYR   R CB  1 
ATOM   1556 C CG  . TYR   B 2 259 ? 132.736 128.373 127.861 1.00 49.32  ? 121 TYR   R CG  1 
ATOM   1557 C CD1 . TYR   B 2 259 ? 131.684 128.625 128.728 1.00 49.73  ? 121 TYR   R CD1 1 
ATOM   1558 C CD2 . TYR   B 2 259 ? 132.441 127.868 126.606 1.00 55.39  ? 121 TYR   R CD2 1 
ATOM   1559 C CE1 . TYR   B 2 259 ? 130.381 128.375 128.359 1.00 47.70  ? 121 TYR   R CE1 1 
ATOM   1560 C CE2 . TYR   B 2 259 ? 131.140 127.616 126.229 1.00 53.92  ? 121 TYR   R CE2 1 
ATOM   1561 C CZ  . TYR   B 2 259 ? 130.115 127.871 127.109 1.00 52.20  ? 121 TYR   R CZ  1 
ATOM   1562 O OH  . TYR   B 2 259 ? 128.817 127.618 126.736 1.00 53.99  ? 121 TYR   R OH  1 
ATOM   1563 N N   . SER   B 2 260 ? 136.730 130.381 129.092 1.00 34.36  ? 122 SER   R N   1 
ATOM   1564 C CA  . SER   B 2 260 ? 138.029 130.348 129.746 1.00 33.59  ? 122 SER   R CA  1 
ATOM   1565 C C   . SER   B 2 260 ? 138.112 131.362 130.876 1.00 40.90  ? 122 SER   R C   1 
ATOM   1566 O O   . SER   B 2 260 ? 138.740 131.094 131.903 1.00 56.90  ? 122 SER   R O   1 
ATOM   1567 C CB  . SER   B 2 260 ? 139.137 130.591 128.723 1.00 44.26  ? 122 SER   R CB  1 
ATOM   1568 O OG  . SER   B 2 260 ? 139.263 131.968 128.426 1.00 53.59  ? 122 SER   R OG  1 
ATOM   1569 N N   . SER   B 2 261 ? 137.489 132.533 130.715 1.00 34.35  ? 123 SER   R N   1 
ATOM   1570 C CA  . SER   B 2 261 ? 137.568 133.545 131.766 1.00 34.58  ? 123 SER   R CA  1 
ATOM   1571 C C   . SER   B 2 261 ? 136.947 133.049 133.070 1.00 40.26  ? 123 SER   R C   1 
ATOM   1572 O O   . SER   B 2 261 ? 137.581 133.092 134.136 1.00 50.14  ? 123 SER   R O   1 
ATOM   1573 C CB  . SER   B 2 261 ? 136.892 134.832 131.296 1.00 43.64  ? 123 SER   R CB  1 
ATOM   1574 O OG  . SER   B 2 261 ? 135.655 134.554 130.665 1.00 59.11  ? 123 SER   R OG  1 
ATOM   1575 N N   . VAL   B 2 262 ? 135.708 132.556 133.004 1.00 27.05  ? 124 VAL   R N   1 
ATOM   1576 C CA  . VAL   B 2 262 ? 135.028 132.122 134.219 1.00 35.94  ? 124 VAL   R CA  1 
ATOM   1577 C C   . VAL   B 2 262 ? 135.704 130.894 134.818 1.00 47.30  ? 124 VAL   R C   1 
ATOM   1578 O O   . VAL   B 2 262 ? 135.788 130.760 136.047 1.00 52.24  ? 124 VAL   R O   1 
ATOM   1579 C CB  . VAL   B 2 262 ? 133.528 131.889 133.941 1.00 34.03  ? 124 VAL   R CB  1 
ATOM   1580 C CG1 . VAL   B 2 262 ? 133.302 130.634 133.124 1.00 41.38  ? 124 VAL   R CG1 1 
ATOM   1581 C CG2 . VAL   B 2 262 ? 132.757 131.823 135.244 1.00 38.47  ? 124 VAL   R CG2 1 
ATOM   1582 N N   . TRP   B 2 263 ? 136.231 129.993 133.984 1.00 40.77  ? 125 TRP   R N   1 
ATOM   1583 C CA  . TRP   B 2 263 ? 136.880 128.830 134.577 1.00 35.01  ? 125 TRP   R CA  1 
ATOM   1584 C C   . TRP   B 2 263 ? 138.259 129.149 135.148 1.00 42.06  ? 125 TRP   R C   1 
ATOM   1585 O O   . TRP   B 2 263 ? 138.678 128.514 136.122 1.00 53.74  ? 125 TRP   R O   1 
ATOM   1586 C CB  . TRP   B 2 263 ? 136.921 127.691 133.568 1.00 33.83  ? 125 TRP   R CB  1 
ATOM   1587 C CG  . TRP   B 2 263 ? 135.608 126.981 133.534 1.00 36.99  ? 125 TRP   R CG  1 
ATOM   1588 C CD1 . TRP   B 2 263 ? 134.706 126.972 132.517 1.00 54.04  ? 125 TRP   R CD1 1 
ATOM   1589 C CD2 . TRP   B 2 263 ? 135.061 126.149 134.565 1.00 45.47  ? 125 TRP   R CD2 1 
ATOM   1590 N NE1 . TRP   B 2 263 ? 133.619 126.205 132.858 1.00 56.30  ? 125 TRP   R NE1 1 
ATOM   1591 C CE2 . TRP   B 2 263 ? 133.817 125.684 134.109 1.00 49.69  ? 125 TRP   R CE2 1 
ATOM   1592 C CE3 . TRP   B 2 263 ? 135.505 125.756 135.831 1.00 48.81  ? 125 TRP   R CE3 1 
ATOM   1593 C CZ2 . TRP   B 2 263 ? 133.011 124.845 134.871 1.00 49.60  ? 125 TRP   R CZ2 1 
ATOM   1594 C CZ3 . TRP   B 2 263 ? 134.703 124.925 136.587 1.00 41.51  ? 125 TRP   R CZ3 1 
ATOM   1595 C CH2 . TRP   B 2 263 ? 133.470 124.478 136.105 1.00 41.28  ? 125 TRP   R CH2 1 
ATOM   1596 N N   . ILE   B 2 264 ? 138.968 130.137 134.599 1.00 29.30  ? 126 ILE   R N   1 
ATOM   1597 C CA  . ILE   B 2 264 ? 140.185 130.608 135.253 1.00 16.42  ? 126 ILE   R CA  1 
ATOM   1598 C C   . ILE   B 2 264 ? 139.850 131.238 136.596 1.00 35.52  ? 126 ILE   R C   1 
ATOM   1599 O O   . ILE   B 2 264 ? 140.593 131.085 137.573 1.00 55.69  ? 126 ILE   R O   1 
ATOM   1600 C CB  . ILE   B 2 264 ? 140.953 131.577 134.336 1.00 25.28  ? 126 ILE   R CB  1 
ATOM   1601 C CG1 . ILE   B 2 264 ? 141.556 130.818 133.154 1.00 39.86  ? 126 ILE   R CG1 1 
ATOM   1602 C CG2 . ILE   B 2 264 ? 142.034 132.309 135.105 1.00 30.86  ? 126 ILE   R CG2 1 
ATOM   1603 C CD1 . ILE   B 2 264 ? 142.087 131.711 132.062 1.00 40.50  ? 126 ILE   R CD1 1 
ATOM   1604 N N   . LEU   B 2 265 ? 138.721 131.947 136.675 1.00 37.83  ? 127 LEU   R N   1 
ATOM   1605 C CA  . LEU   B 2 265 ? 138.285 132.469 137.970 1.00 35.11  ? 127 LEU   R CA  1 
ATOM   1606 C C   . LEU   B 2 265 ? 138.025 131.339 138.963 1.00 34.11  ? 127 LEU   R C   1 
ATOM   1607 O O   . LEU   B 2 265 ? 138.401 131.431 140.141 1.00 35.28  ? 127 LEU   R O   1 
ATOM   1608 C CB  . LEU   B 2 265 ? 137.036 133.330 137.797 1.00 33.61  ? 127 LEU   R CB  1 
ATOM   1609 C CG  . LEU   B 2 265 ? 137.243 134.756 137.287 1.00 23.91  ? 127 LEU   R CG  1 
ATOM   1610 C CD1 . LEU   B 2 265 ? 135.956 135.542 137.393 1.00 39.12  ? 127 LEU   R CD1 1 
ATOM   1611 C CD2 . LEU   B 2 265 ? 138.349 135.439 138.060 1.00 27.08  ? 127 LEU   R CD2 1 
ATOM   1612 N N   . ALA   B 2 266 ? 137.380 130.263 138.504 1.00 37.95  ? 128 ALA   R N   1 
ATOM   1613 C CA  . ALA   B 2 266 ? 137.143 129.113 139.377 1.00 27.04  ? 128 ALA   R CA  1 
ATOM   1614 C C   . ALA   B 2 266 ? 138.452 128.477 139.837 1.00 19.31  ? 128 ALA   R C   1 
ATOM   1615 O O   . ALA   B 2 266 ? 138.572 128.049 140.991 1.00 37.00  ? 128 ALA   R O   1 
ATOM   1616 C CB  . ALA   B 2 266 ? 136.272 128.080 138.666 1.00 29.32  ? 128 ALA   R CB  1 
ATOM   1617 N N   . PHE   B 2 267 ? 139.440 128.391 138.944 1.00 39.00  ? 129 PHE   R N   1 
ATOM   1618 C CA  . PHE   B 2 267 ? 140.740 127.851 139.340 1.00 39.27  ? 129 PHE   R CA  1 
ATOM   1619 C C   . PHE   B 2 267 ? 141.435 128.753 140.354 1.00 33.52  ? 129 PHE   R C   1 
ATOM   1620 O O   . PHE   B 2 267 ? 142.098 128.260 141.274 1.00 48.61  ? 129 PHE   R O   1 
ATOM   1621 C CB  . PHE   B 2 267 ? 141.626 127.635 138.114 1.00 44.68  ? 129 PHE   R CB  1 
ATOM   1622 C CG  . PHE   B 2 267 ? 141.593 126.230 137.591 1.00 45.75  ? 129 PHE   R CG  1 
ATOM   1623 C CD1 . PHE   B 2 267 ? 140.387 125.615 137.299 1.00 44.03  ? 129 PHE   R CD1 1 
ATOM   1624 C CD2 . PHE   B 2 267 ? 142.762 125.517 137.412 1.00 42.79  ? 129 PHE   R CD2 1 
ATOM   1625 C CE1 . PHE   B 2 267 ? 140.351 124.320 136.827 1.00 43.99  ? 129 PHE   R CE1 1 
ATOM   1626 C CE2 . PHE   B 2 267 ? 142.730 124.222 136.939 1.00 44.79  ? 129 PHE   R CE2 1 
ATOM   1627 C CZ  . PHE   B 2 267 ? 141.523 123.623 136.647 1.00 49.87  ? 129 PHE   R CZ  1 
ATOM   1628 N N   . ILE   B 2 268 ? 141.300 130.073 140.206 1.00 34.05  ? 130 ILE   R N   1 
ATOM   1629 C CA  . ILE   B 2 268 ? 141.832 130.992 141.212 1.00 42.56  ? 130 ILE   R CA  1 
ATOM   1630 C C   . ILE   B 2 268 ? 141.184 130.727 142.563 1.00 48.52  ? 130 ILE   R C   1 
ATOM   1631 O O   . ILE   B 2 268 ? 141.859 130.692 143.600 1.00 53.24  ? 130 ILE   R O   1 
ATOM   1632 C CB  . ILE   B 2 268 ? 141.621 132.455 140.779 1.00 36.86  ? 130 ILE   R CB  1 
ATOM   1633 C CG1 . ILE   B 2 268 ? 142.418 132.772 139.521 1.00 41.72  ? 130 ILE   R CG1 1 
ATOM   1634 C CG2 . ILE   B 2 268 ? 142.011 133.404 141.900 1.00 32.26  ? 130 ILE   R CG2 1 
ATOM   1635 C CD1 . ILE   B 2 268 ? 142.159 134.154 138.975 1.00 39.87  ? 130 ILE   R CD1 1 
ATOM   1636 N N   . SER   B 2 269 ? 139.862 130.546 142.574 1.00 40.59  ? 131 SER   R N   1 
ATOM   1637 C CA  . SER   B 2 269 ? 139.164 130.282 143.829 1.00 31.99  ? 131 SER   R CA  1 
ATOM   1638 C C   . SER   B 2 269 ? 139.635 128.980 144.465 1.00 42.15  ? 131 SER   R C   1 
ATOM   1639 O O   . SER   B 2 269 ? 139.846 128.912 145.684 1.00 49.42  ? 131 SER   R O   1 
ATOM   1640 C CB  . SER   B 2 269 ? 137.659 130.241 143.588 1.00 42.43  ? 131 SER   R CB  1 
ATOM   1641 O OG  . SER   B 2 269 ? 137.244 131.365 142.838 1.00 52.89  ? 131 SER   R OG  1 
ATOM   1642 N N   . LEU   B 2 270 ? 139.792 127.930 143.657 1.00 43.11  ? 132 LEU   R N   1 
ATOM   1643 C CA  . LEU   B 2 270 ? 140.252 126.651 144.188 1.00 35.42  ? 132 LEU   R CA  1 
ATOM   1644 C C   . LEU   B 2 270 ? 141.666 126.765 144.741 1.00 39.53  ? 132 LEU   R C   1 
ATOM   1645 O O   . LEU   B 2 270 ? 141.985 126.186 145.788 1.00 50.40  ? 132 LEU   R O   1 
ATOM   1646 C CB  . LEU   B 2 270 ? 140.181 125.581 143.102 1.00 38.06  ? 132 LEU   R CB  1 
ATOM   1647 C CG  . LEU   B 2 270 ? 140.435 124.142 143.545 1.00 51.29  ? 132 LEU   R CG  1 
ATOM   1648 C CD1 . LEU   B 2 270 ? 139.342 123.684 144.495 1.00 49.69  ? 132 LEU   R CD1 1 
ATOM   1649 C CD2 . LEU   B 2 270 ? 140.529 123.223 142.339 1.00 45.50  ? 132 LEU   R CD2 1 
ATOM   1650 N N   . ASP   B 2 271 ? 142.528 127.512 144.049 1.00 43.68  ? 133 ASP   R N   1 
ATOM   1651 C CA  . ASP   B 2 271 ? 143.875 127.753 144.550 1.00 38.42  ? 133 ASP   R CA  1 
ATOM   1652 C C   . ASP   B 2 271 ? 143.840 128.480 145.886 1.00 43.52  ? 133 ASP   R C   1 
ATOM   1653 O O   . ASP   B 2 271 ? 144.615 128.162 146.793 1.00 51.10  ? 133 ASP   R O   1 
ATOM   1654 C CB  . ASP   B 2 271 ? 144.670 128.554 143.522 1.00 47.88  ? 133 ASP   R CB  1 
ATOM   1655 C CG  . ASP   B 2 271 ? 146.050 128.921 144.010 1.00 54.85  ? 133 ASP   R CG  1 
ATOM   1656 O OD1 . ASP   B 2 271 ? 146.990 128.135 143.778 1.00 63.97  ? 133 ASP   R OD1 1 
ATOM   1657 O OD2 . ASP   B 2 271 ? 146.199 129.999 144.619 1.00 54.74  ? 133 ASP   R OD2 1 
ATOM   1658 N N   . ARG   B 2 272 ? 142.949 129.465 146.022 1.00 54.64  ? 134 ARG   R N   1 
ATOM   1659 C CA  . ARG   B 2 272 ? 142.829 130.188 147.286 1.00 50.39  ? 134 ARG   R CA  1 
ATOM   1660 C C   . ARG   B 2 272 ? 142.372 129.269 148.412 1.00 52.06  ? 134 ARG   R C   1 
ATOM   1661 O O   . ARG   B 2 272 ? 142.892 129.340 149.534 1.00 50.76  ? 134 ARG   R O   1 
ATOM   1662 C CB  . ARG   B 2 272 ? 141.862 131.360 147.125 1.00 42.31  ? 134 ARG   R CB  1 
ATOM   1663 C CG  . ARG   B 2 272 ? 142.516 132.635 146.643 1.00 41.31  ? 134 ARG   R CG  1 
ATOM   1664 C CD  . ARG   B 2 272 ? 143.694 133.002 147.518 1.00 39.30  ? 134 ARG   R CD  1 
ATOM   1665 N NE  . ARG   B 2 272 ? 144.961 132.643 146.897 1.00 43.20  ? 134 ARG   R NE  1 
ATOM   1666 C CZ  . ARG   B 2 272 ? 146.120 132.595 147.537 1.00 50.86  ? 134 ARG   R CZ  1 
ATOM   1667 N NH1 . ARG   B 2 272 ? 146.210 132.874 148.826 1.00 58.23  ? 134 ARG   R NH1 1 
ATOM   1668 N NH2 . ARG   B 2 272 ? 147.217 132.258 146.867 1.00 54.72  ? 134 ARG   R NH2 1 
ATOM   1669 N N   . TYR   B 2 273 ? 141.392 128.406 148.134 1.00 53.79  ? 135 TYR   R N   1 
ATOM   1670 C CA  . TYR   B 2 273 ? 140.932 127.460 149.147 1.00 47.65  ? 135 TYR   R CA  1 
ATOM   1671 C C   . TYR   B 2 273 ? 142.058 126.533 149.581 1.00 45.36  ? 135 TYR   R C   1 
ATOM   1672 O O   . TYR   B 2 273 ? 142.246 126.289 150.780 1.00 55.40  ? 135 TYR   R O   1 
ATOM   1673 C CB  . TYR   B 2 273 ? 139.750 126.652 148.614 1.00 47.07  ? 135 TYR   R CB  1 
ATOM   1674 C CG  . TYR   B 2 273 ? 139.428 125.411 149.418 1.00 43.97  ? 135 TYR   R CG  1 
ATOM   1675 C CD1 . TYR   B 2 273 ? 139.997 124.185 149.101 1.00 52.88  ? 135 TYR   R CD1 1 
ATOM   1676 C CD2 . TYR   B 2 273 ? 138.543 125.463 150.484 1.00 55.14  ? 135 TYR   R CD2 1 
ATOM   1677 C CE1 . TYR   B 2 273 ? 139.705 123.051 149.831 1.00 59.36  ? 135 TYR   R CE1 1 
ATOM   1678 C CE2 . TYR   B 2 273 ? 138.242 124.332 151.218 1.00 59.19  ? 135 TYR   R CE2 1 
ATOM   1679 C CZ  . TYR   B 2 273 ? 138.826 123.129 150.886 1.00 58.49  ? 135 TYR   R CZ  1 
ATOM   1680 O OH  . TYR   B 2 273 ? 138.532 121.999 151.613 1.00 53.88  ? 135 TYR   R OH  1 
ATOM   1681 N N   . LEU   B 2 274 ? 142.822 126.010 148.618 1.00 59.47  ? 136 LEU   R N   1 
ATOM   1682 C CA  . LEU   B 2 274 ? 143.946 125.143 148.955 1.00 55.94  ? 136 LEU   R CA  1 
ATOM   1683 C C   . LEU   B 2 274 ? 144.997 125.889 149.765 1.00 51.17  ? 136 LEU   R C   1 
ATOM   1684 O O   . LEU   B 2 274 ? 145.587 125.328 150.693 1.00 49.49  ? 136 LEU   R O   1 
ATOM   1685 C CB  . LEU   B 2 274 ? 144.569 124.566 147.686 1.00 51.20  ? 136 LEU   R CB  1 
ATOM   1686 C CG  . LEU   B 2 274 ? 144.135 123.154 147.297 1.00 53.40  ? 136 LEU   R CG  1 
ATOM   1687 C CD1 . LEU   B 2 274 ? 144.669 122.807 145.924 1.00 56.86  ? 136 LEU   R CD1 1 
ATOM   1688 C CD2 . LEU   B 2 274 ? 144.608 122.147 148.327 1.00 52.32  ? 136 LEU   R CD2 1 
ATOM   1689 N N   . ALA   B 2 275 ? 145.251 127.152 149.423 1.00 51.78  ? 137 ALA   R N   1 
ATOM   1690 C CA  . ALA   B 2 275 ? 146.284 127.910 150.119 1.00 43.96  ? 137 ALA   R CA  1 
ATOM   1691 C C   . ALA   B 2 275 ? 145.884 128.219 151.553 1.00 45.28  ? 137 ALA   R C   1 
ATOM   1692 O O   . ALA   B 2 275 ? 146.726 128.183 152.456 1.00 53.79  ? 137 ALA   R O   1 
ATOM   1693 C CB  . ALA   B 2 275 ? 146.585 129.201 149.362 1.00 53.99  ? 137 ALA   R CB  1 
ATOM   1694 N N   . ILE   B 2 276 ? 144.613 128.530 151.786 1.00 55.86  ? 138 ILE   R N   1 
ATOM   1695 C CA  . ILE   B 2 276 ? 144.193 129.003 153.103 1.00 54.63  ? 138 ILE   R CA  1 
ATOM   1696 C C   . ILE   B 2 276 ? 143.811 127.850 154.023 1.00 54.06  ? 138 ILE   R C   1 
ATOM   1697 O O   . ILE   B 2 276 ? 144.264 127.789 155.169 1.00 55.98  ? 138 ILE   R O   1 
ATOM   1698 C CB  . ILE   B 2 276 ? 143.043 130.023 152.956 1.00 52.06  ? 138 ILE   R CB  1 
ATOM   1699 C CG1 . ILE   B 2 276 ? 143.611 131.408 152.642 1.00 48.69  ? 138 ILE   R CG1 1 
ATOM   1700 C CG2 . ILE   B 2 276 ? 142.206 130.075 154.220 1.00 54.58  ? 138 ILE   R CG2 1 
ATOM   1701 C CD1 . ILE   B 2 276 ? 142.565 132.449 152.353 1.00 49.41  ? 138 ILE   R CD1 1 
ATOM   1702 N N   . VAL   B 2 277 ? 142.976 126.918 153.558 1.00 59.90  ? 139 VAL   R N   1 
ATOM   1703 C CA  . VAL   B 2 277 ? 142.517 125.851 154.443 1.00 53.40  ? 139 VAL   R CA  1 
ATOM   1704 C C   . VAL   B 2 277 ? 143.648 124.876 154.757 1.00 52.59  ? 139 VAL   R C   1 
ATOM   1705 O O   . VAL   B 2 277 ? 143.847 124.492 155.915 1.00 59.02  ? 139 VAL   R O   1 
ATOM   1706 C CB  . VAL   B 2 277 ? 141.300 125.137 153.833 1.00 52.83  ? 139 VAL   R CB  1 
ATOM   1707 C CG1 . VAL   B 2 277 ? 140.871 123.983 154.713 1.00 56.77  ? 139 VAL   R CG1 1 
ATOM   1708 C CG2 . VAL   B 2 277 ? 140.160 126.118 153.659 1.00 46.52  ? 139 VAL   R CG2 1 
ATOM   1709 N N   . HIS   B 2 278 ? 144.408 124.466 153.746 1.00 54.67  ? 140 HIS   R N   1 
ATOM   1710 C CA  . HIS   B 2 278 ? 145.525 123.536 153.915 1.00 54.28  ? 140 HIS   R CA  1 
ATOM   1711 C C   . HIS   B 2 278 ? 146.809 124.307 153.619 1.00 63.23  ? 140 HIS   R C   1 
ATOM   1712 O O   . HIS   B 2 278 ? 147.324 124.274 152.502 1.00 76.86  ? 140 HIS   R O   1 
ATOM   1713 C CB  . HIS   B 2 278 ? 145.380 122.330 152.993 1.00 60.53  ? 140 HIS   R CB  1 
ATOM   1714 C CG  . HIS   B 2 278 ? 144.002 121.745 152.967 1.00 67.22  ? 140 HIS   R CG  1 
ATOM   1715 N ND1 . HIS   B 2 278 ? 143.530 120.902 153.949 1.00 69.82  ? 140 HIS   R ND1 1 
ATOM   1716 C CD2 . HIS   B 2 278 ? 142.997 121.876 152.070 1.00 63.48  ? 140 HIS   R CD2 1 
ATOM   1717 C CE1 . HIS   B 2 278 ? 142.293 120.541 153.660 1.00 66.59  ? 140 HIS   R CE1 1 
ATOM   1718 N NE2 . HIS   B 2 278 ? 141.945 121.119 152.525 1.00 61.09  ? 140 HIS   R NE2 1 
ATOM   1719 N N   . ALA   B 2 279 ? 147.342 124.981 154.633 1.00 66.00  ? 141 ALA   R N   1 
ATOM   1720 C CA  . ALA   B 2 279 ? 148.412 125.952 154.439 1.00 70.89  ? 141 ALA   R CA  1 
ATOM   1721 C C   . ALA   B 2 279 ? 149.811 125.360 154.579 1.00 73.23  ? 141 ALA   R C   1 
ATOM   1722 O O   . ALA   B 2 279 ? 150.790 126.112 154.536 1.00 70.68  ? 141 ALA   R O   1 
ATOM   1723 C CB  . ALA   B 2 279 ? 148.246 127.116 155.419 1.00 64.15  ? 141 ALA   R CB  1 
ATOM   1724 N N   . THR   B 2 280 ? 149.936 124.047 154.745 1.00 81.21  ? 142 THR   R N   1 
ATOM   1725 C CA  . THR   B 2 280 ? 151.244 123.434 154.951 1.00 74.80  ? 142 THR   R CA  1 
ATOM   1726 C C   . THR   B 2 280 ? 151.619 122.410 153.892 1.00 77.65  ? 142 THR   R C   1 
ATOM   1727 O O   . THR   B 2 280 ? 152.758 122.414 153.421 1.00 84.43  ? 142 THR   R O   1 
ATOM   1728 C CB  . THR   B 2 280 ? 151.305 122.769 156.333 1.00 80.16  ? 142 THR   R CB  1 
ATOM   1729 O OG1 . THR   B 2 280 ? 150.259 121.796 156.444 1.00 81.75  ? 142 THR   R OG1 1 
ATOM   1730 C CG2 . THR   B 2 280 ? 151.147 123.808 157.432 1.00 80.26  ? 142 THR   R CG2 1 
ATOM   1731 N N   . ASN   B 2 281 ? 150.698 121.533 153.499 1.00 84.22  ? 143 ASN   R N   1 
ATOM   1732 C CA  . ASN   B 2 281 ? 151.004 120.438 152.588 1.00 86.03  ? 143 ASN   R CA  1 
ATOM   1733 C C   . ASN   B 2 281 ? 150.544 120.701 151.158 1.00 83.48  ? 143 ASN   R C   1 
ATOM   1734 O O   . ASN   B 2 281 ? 150.523 119.772 150.346 1.00 85.73  ? 143 ASN   R O   1 
ATOM   1735 C CB  . ASN   B 2 281 ? 150.381 119.137 153.101 1.00 82.80  ? 143 ASN   R CB  1 
ATOM   1736 C CG  . ASN   B 2 281 ? 148.876 119.239 153.294 1.00 84.12  ? 143 ASN   R CG  1 
ATOM   1737 O OD1 . ASN   B 2 281 ? 148.264 120.263 152.991 1.00 81.91  ? 143 ASN   R OD1 1 
ATOM   1738 N ND2 . ASN   B 2 281 ? 148.273 118.170 153.798 1.00 83.01  ? 143 ASN   R ND2 1 
ATOM   1739 N N   . SER   B 2 282 ? 150.182 121.938 150.831 1.00 74.44  ? 144 SER   R N   1 
ATOM   1740 C CA  . SER   B 2 282 ? 149.565 122.252 149.551 1.00 73.52  ? 144 SER   R CA  1 
ATOM   1741 C C   . SER   B 2 282 ? 150.559 122.675 148.479 1.00 75.90  ? 144 SER   R C   1 
ATOM   1742 O O   . SER   B 2 282 ? 150.139 122.961 147.353 1.00 79.69  ? 144 SER   R O   1 
ATOM   1743 C CB  . SER   B 2 282 ? 148.524 123.358 149.731 1.00 74.70  ? 144 SER   R CB  1 
ATOM   1744 O OG  . SER   B 2 282 ? 149.120 124.528 150.262 1.00 71.98  ? 144 SER   R OG  1 
ATOM   1745 N N   . GLN   B 2 283 ? 151.856 122.722 148.788 1.00 80.64  ? 145 GLN   R N   1 
ATOM   1746 C CA  . GLN   B 2 283 ? 152.819 123.224 147.813 1.00 82.15  ? 145 GLN   R CA  1 
ATOM   1747 C C   . GLN   B 2 283 ? 152.845 122.359 146.560 1.00 83.25  ? 145 GLN   R C   1 
ATOM   1748 O O   . GLN   B 2 283 ? 152.829 122.879 145.439 1.00 82.06  ? 145 GLN   R O   1 
ATOM   1749 C CB  . GLN   B 2 283 ? 154.210 123.308 148.438 1.00 82.58  ? 145 GLN   R CB  1 
ATOM   1750 C CG  . GLN   B 2 283 ? 154.487 124.617 149.159 1.00 85.21  ? 145 GLN   R CG  1 
ATOM   1751 C CD  . GLN   B 2 283 ? 154.406 125.819 148.239 1.00 85.96  ? 145 GLN   R CD  1 
ATOM   1752 O OE1 . GLN   B 2 283 ? 154.703 125.726 147.049 1.00 85.91  ? 145 GLN   R OE1 1 
ATOM   1753 N NE2 . GLN   B 2 283 ? 154.003 126.958 148.789 1.00 82.30  ? 145 GLN   R NE2 1 
ATOM   1754 N N   . ARG   B 2 284 ? 152.857 121.033 146.725 1.00 88.41  ? 146 ARG   R N   1 
ATOM   1755 C CA  . ARG   B 2 284 ? 152.890 120.165 145.549 1.00 87.58  ? 146 ARG   R CA  1 
ATOM   1756 C C   . ARG   B 2 284 ? 151.572 120.189 144.783 1.00 89.56  ? 146 ARG   R C   1 
ATOM   1757 O O   . ARG   B 2 284 ? 151.604 120.383 143.553 1.00 91.14  ? 146 ARG   R O   1 
ATOM   1758 C CB  . ARG   B 2 284 ? 153.303 118.748 145.957 1.00 84.26  ? 146 ARG   R CB  1 
ATOM   1759 C CG  . ARG   B 2 284 ? 153.909 117.933 144.833 1.00 86.69  ? 146 ARG   R CG  1 
ATOM   1760 C CD  . ARG   B 2 284 ? 155.393 118.211 144.693 1.00 88.80  ? 146 ARG   R CD  1 
ATOM   1761 N NE  . ARG   B 2 284 ? 156.042 117.247 143.814 1.00 91.32  ? 146 ARG   R NE  1 
ATOM   1762 C CZ  . ARG   B 2 284 ? 157.318 117.298 143.458 1.00 92.40  ? 146 ARG   R CZ  1 
ATOM   1763 N NH1 . ARG   B 2 284 ? 158.120 118.255 143.895 1.00 92.57  ? 146 ARG   R NH1 1 
ATOM   1764 N NH2 . ARG   B 2 284 ? 157.802 116.365 142.643 1.00 90.61  ? 146 ARG   R NH2 1 
ATOM   1765 N N   . PRO   B 2 285 ? 150.388 119.984 145.411 1.00 77.93  ? 147 PRO   R N   1 
ATOM   1766 C CA  . PRO   B 2 285 ? 149.143 120.164 144.653 1.00 71.99  ? 147 PRO   R CA  1 
ATOM   1767 C C   . PRO   B 2 285 ? 148.700 121.616 144.643 1.00 74.36  ? 147 PRO   R C   1 
ATOM   1768 O O   . PRO   B 2 285 ? 147.508 121.918 144.742 1.00 82.01  ? 147 PRO   R O   1 
ATOM   1769 C CB  . PRO   B 2 285 ? 148.137 119.285 145.410 1.00 73.20  ? 147 PRO   R CB  1 
ATOM   1770 C CG  . PRO   B 2 285 ? 148.952 118.499 146.404 1.00 76.21  ? 147 PRO   R CG  1 
ATOM   1771 C CD  . PRO   B 2 285 ? 150.105 119.383 146.721 1.00 76.93  ? 147 PRO   R CD  1 
ATOM   1772 N N   . ARG   B 2 286 ? 149.664 122.520 144.515 1.00 66.09  ? 148 ARG   R N   1 
ATOM   1773 C CA  . ARG   B 2 286 ? 149.404 123.928 144.261 1.00 68.20  ? 148 ARG   R CA  1 
ATOM   1774 C C   . ARG   B 2 286 ? 150.324 124.350 143.129 1.00 69.75  ? 148 ARG   R C   1 
ATOM   1775 O O   . ARG   B 2 286 ? 150.039 125.296 142.388 1.00 74.60  ? 148 ARG   R O   1 
ATOM   1776 C CB  . ARG   B 2 286 ? 149.634 124.757 145.524 1.00 67.69  ? 148 ARG   R CB  1 
ATOM   1777 C CG  . ARG   B 2 286 ? 149.252 126.215 145.405 1.00 68.43  ? 148 ARG   R CG  1 
ATOM   1778 C CD  . ARG   B 2 286 ? 149.235 126.881 146.767 1.00 61.36  ? 148 ARG   R CD  1 
ATOM   1779 N NE  . ARG   B 2 286 ? 148.955 128.306 146.658 1.00 62.41  ? 148 ARG   R NE  1 
ATOM   1780 C CZ  . ARG   B 2 286 ? 149.888 129.237 146.529 1.00 68.82  ? 148 ARG   R CZ  1 
ATOM   1781 N NH1 . ARG   B 2 286 ? 151.173 128.929 146.511 1.00 75.15  ? 148 ARG   R NH1 1 
ATOM   1782 N NH2 . ARG   B 2 286 ? 149.522 130.510 146.413 1.00 65.41  ? 148 ARG   R NH2 1 
ATOM   1783 N N   . LYS   B 2 287 ? 151.442 123.637 143.007 1.00 64.16  ? 149 LYS   R N   1 
ATOM   1784 C CA  . LYS   B 2 287 ? 152.301 123.762 141.839 1.00 63.13  ? 149 LYS   R CA  1 
ATOM   1785 C C   . LYS   B 2 287 ? 151.750 122.957 140.669 1.00 63.01  ? 149 LYS   R C   1 
ATOM   1786 O O   . LYS   B 2 287 ? 151.684 123.456 139.540 1.00 72.22  ? 149 LYS   R O   1 
ATOM   1787 C CB  . LYS   B 2 287 ? 153.717 123.306 142.191 1.00 73.49  ? 149 LYS   R CB  1 
ATOM   1788 C CG  . LYS   B 2 287 ? 154.727 123.471 141.075 1.00 75.72  ? 149 LYS   R CG  1 
ATOM   1789 C CD  . LYS   B 2 287 ? 156.128 123.124 141.551 1.00 76.33  ? 149 LYS   R CD  1 
ATOM   1790 C CE  . LYS   B 2 287 ? 157.138 123.233 140.421 1.00 75.25  ? 149 LYS   R CE  1 
ATOM   1791 N NZ  . LYS   B 2 287 ? 156.984 122.126 139.436 1.00 74.89  ? 149 LYS   R NZ  1 
ATOM   1792 N N   . LEU   B 2 288 ? 151.348 121.709 140.921 1.00 63.58  ? 150 LEU   R N   1 
ATOM   1793 C CA  . LEU   B 2 288 ? 150.840 120.861 139.845 1.00 64.68  ? 150 LEU   R CA  1 
ATOM   1794 C C   . LEU   B 2 288 ? 149.560 121.430 139.249 1.00 67.39  ? 150 LEU   R C   1 
ATOM   1795 O O   . LEU   B 2 288 ? 149.413 121.518 138.023 1.00 68.03  ? 150 LEU   R O   1 
ATOM   1796 C CB  . LEU   B 2 288 ? 150.603 119.443 140.365 1.00 65.24  ? 150 LEU   R CB  1 
ATOM   1797 C CG  . LEU   B 2 288 ? 151.754 118.436 140.315 1.00 73.03  ? 150 LEU   R CG  1 
ATOM   1798 C CD1 . LEU   B 2 288 ? 152.098 118.119 138.875 1.00 70.65  ? 150 LEU   R CD1 1 
ATOM   1799 C CD2 . LEU   B 2 288 ? 152.985 118.931 141.060 1.00 72.44  ? 150 LEU   R CD2 1 
ATOM   1800 N N   . LEU   B 2 289 ? 148.623 121.832 140.110 1.00 60.63  ? 151 LEU   R N   1 
ATOM   1801 C CA  . LEU   B 2 289 ? 147.328 122.318 139.646 1.00 48.67  ? 151 LEU   R CA  1 
ATOM   1802 C C   . LEU   B 2 289 ? 147.462 123.589 138.819 1.00 59.28  ? 151 LEU   R C   1 
ATOM   1803 O O   . LEU   B 2 289 ? 146.630 123.850 137.944 1.00 60.26  ? 151 LEU   R O   1 
ATOM   1804 C CB  . LEU   B 2 289 ? 146.412 122.556 140.846 1.00 48.43  ? 151 LEU   R CB  1 
ATOM   1805 C CG  . LEU   B 2 289 ? 144.938 122.844 140.579 1.00 56.13  ? 151 LEU   R CG  1 
ATOM   1806 C CD1 . LEU   B 2 289 ? 144.201 121.563 140.253 1.00 62.42  ? 151 LEU   R CD1 1 
ATOM   1807 C CD2 . LEU   B 2 289 ? 144.317 123.529 141.780 1.00 53.80  ? 151 LEU   R CD2 1 
ATOM   1808 N N   . ALA   B 2 290 ? 148.493 124.389 139.079 1.00 63.61  ? 152 ALA   R N   1 
ATOM   1809 C CA  . ALA   B 2 290 ? 148.707 125.623 138.339 1.00 51.39  ? 152 ALA   R CA  1 
ATOM   1810 C C   . ALA   B 2 290 ? 149.613 125.449 137.132 1.00 55.18  ? 152 ALA   R C   1 
ATOM   1811 O O   . ALA   B 2 290 ? 149.596 126.302 136.238 1.00 65.62  ? 152 ALA   R O   1 
ATOM   1812 C CB  . ALA   B 2 290 ? 149.305 126.695 139.254 1.00 52.27  ? 152 ALA   R CB  1 
ATOM   1813 N N   . GLU   B 2 291 ? 150.404 124.378 137.079 1.00 58.50  ? 153 GLU   R N   1 
ATOM   1814 C CA  . GLU   B 2 291 ? 151.338 124.196 135.977 1.00 58.13  ? 153 GLU   R CA  1 
ATOM   1815 C C   . GLU   B 2 291 ? 150.833 123.255 134.894 1.00 61.57  ? 153 GLU   R C   1 
ATOM   1816 O O   . GLU   B 2 291 ? 151.046 123.528 133.711 1.00 68.59  ? 153 GLU   R O   1 
ATOM   1817 C CB  . GLU   B 2 291 ? 152.683 123.690 136.504 1.00 70.70  ? 153 GLU   R CB  1 
ATOM   1818 C CG  . GLU   B 2 291 ? 153.690 124.799 136.754 1.00 71.40  ? 153 GLU   R CG  1 
ATOM   1819 C CD  . GLU   B 2 291 ? 154.804 124.384 137.692 1.00 73.09  ? 153 GLU   R CD  1 
ATOM   1820 O OE1 . GLU   B 2 291 ? 155.192 123.196 137.672 1.00 67.34  ? 153 GLU   R OE1 1 
ATOM   1821 O OE2 . GLU   B 2 291 ? 155.296 125.249 138.446 1.00 72.53  ? 153 GLU   R OE2 1 
ATOM   1822 N N   . LYS   B 2 292 ? 150.174 122.156 135.249 1.00 63.19  ? 154 LYS   R N   1 
ATOM   1823 C CA  . LYS   B 2 292 ? 149.742 121.207 134.228 1.00 64.14  ? 154 LYS   R CA  1 
ATOM   1824 C C   . LYS   B 2 292 ? 148.242 120.974 134.196 1.00 59.44  ? 154 LYS   R C   1 
ATOM   1825 O O   . LYS   B 2 292 ? 147.665 120.873 133.112 1.00 56.84  ? 154 LYS   R O   1 
ATOM   1826 C CB  . LYS   B 2 292 ? 150.461 119.861 134.409 1.00 56.11  ? 154 LYS   R CB  1 
ATOM   1827 C CG  . LYS   B 2 292 ? 151.963 119.941 134.219 1.00 58.27  ? 154 LYS   R CG  1 
ATOM   1828 C CD  . LYS   B 2 292 ? 152.585 118.560 134.131 1.00 64.51  ? 154 LYS   R CD  1 
ATOM   1829 C CE  . LYS   B 2 292 ? 153.084 118.090 135.481 1.00 68.04  ? 154 LYS   R CE  1 
ATOM   1830 N NZ  . LYS   B 2 292 ? 153.057 116.607 135.605 1.00 67.77  ? 154 LYS   R NZ  1 
ATOM   1831 N N   . VAL   B 2 293 ? 147.588 120.879 135.355 1.00 59.19  ? 155 VAL   R N   1 
ATOM   1832 C CA  . VAL   B 2 293 ? 146.157 120.619 135.371 1.00 48.86  ? 155 VAL   R CA  1 
ATOM   1833 C C   . VAL   B 2 293 ? 145.366 121.794 134.813 1.00 51.99  ? 155 VAL   R C   1 
ATOM   1834 O O   . VAL   B 2 293 ? 144.235 121.606 134.351 1.00 54.94  ? 155 VAL   R O   1 
ATOM   1835 C CB  . VAL   B 2 293 ? 145.701 120.270 136.801 1.00 53.14  ? 155 VAL   R CB  1 
ATOM   1836 C CG1 . VAL   B 2 293 ? 144.251 119.806 136.814 1.00 50.47  ? 155 VAL   R CG1 1 
ATOM   1837 C CG2 . VAL   B 2 293 ? 146.603 119.204 137.391 1.00 61.45  ? 155 VAL   R CG2 1 
ATOM   1838 N N   . VAL   B 2 294 ? 145.932 123.005 134.832 1.00 59.68  ? 156 VAL   R N   1 
ATOM   1839 C CA  . VAL   B 2 294 ? 145.194 124.178 134.367 1.00 56.99  ? 156 VAL   R CA  1 
ATOM   1840 C C   . VAL   B 2 294 ? 144.852 124.049 132.889 1.00 56.61  ? 156 VAL   R C   1 
ATOM   1841 O O   . VAL   B 2 294 ? 143.729 124.352 132.472 1.00 61.78  ? 156 VAL   R O   1 
ATOM   1842 C CB  . VAL   B 2 294 ? 145.978 125.471 134.662 1.00 59.64  ? 156 VAL   R CB  1 
ATOM   1843 C CG1 . VAL   B 2 294 ? 147.338 125.459 133.993 1.00 57.39  ? 156 VAL   R CG1 1 
ATOM   1844 C CG2 . VAL   B 2 294 ? 145.184 126.681 134.210 1.00 50.34  ? 156 VAL   R CG2 1 
ATOM   1845 N N   . TYR   B 2 295 ? 145.801 123.581 132.077 1.00 62.33  ? 157 TYR   R N   1 
ATOM   1846 C CA  . TYR   B 2 295 ? 145.548 123.446 130.647 1.00 59.82  ? 157 TYR   R CA  1 
ATOM   1847 C C   . TYR   B 2 295 ? 144.430 122.448 130.381 1.00 59.12  ? 157 TYR   R C   1 
ATOM   1848 O O   . TYR   B 2 295 ? 143.444 122.774 129.712 1.00 50.50  ? 157 TYR   R O   1 
ATOM   1849 C CB  . TYR   B 2 295 ? 146.831 123.036 129.929 1.00 50.64  ? 157 TYR   R CB  1 
ATOM   1850 C CG  . TYR   B 2 295 ? 147.909 124.088 130.008 1.00 57.63  ? 157 TYR   R CG  1 
ATOM   1851 C CD1 . TYR   B 2 295 ? 147.878 125.200 129.183 1.00 58.79  ? 157 TYR   R CD1 1 
ATOM   1852 C CD2 . TYR   B 2 295 ? 148.949 123.976 130.916 1.00 57.38  ? 157 TYR   R CD2 1 
ATOM   1853 C CE1 . TYR   B 2 295 ? 148.857 126.167 129.254 1.00 56.39  ? 157 TYR   R CE1 1 
ATOM   1854 C CE2 . TYR   B 2 295 ? 149.932 124.939 130.995 1.00 58.97  ? 157 TYR   R CE2 1 
ATOM   1855 C CZ  . TYR   B 2 295 ? 149.880 126.032 130.161 1.00 59.18  ? 157 TYR   R CZ  1 
ATOM   1856 O OH  . TYR   B 2 295 ? 150.858 126.994 130.236 1.00 63.96  ? 157 TYR   R OH  1 
ATOM   1857 N N   . VAL   B 2 296 ? 144.540 121.249 130.956 1.00 67.64  ? 158 VAL   R N   1 
ATOM   1858 C CA  . VAL   B 2 296 ? 143.550 120.201 130.733 1.00 64.59  ? 158 VAL   R CA  1 
ATOM   1859 C C   . VAL   B 2 296 ? 142.183 120.607 131.266 1.00 62.25  ? 158 VAL   R C   1 
ATOM   1860 O O   . VAL   B 2 296 ? 141.154 120.272 130.668 1.00 61.62  ? 158 VAL   R O   1 
ATOM   1861 C CB  . VAL   B 2 296 ? 144.033 118.880 131.367 1.00 67.84  ? 158 VAL   R CB  1 
ATOM   1862 C CG1 . VAL   B 2 296 ? 142.983 117.792 131.212 1.00 64.34  ? 158 VAL   R CG1 1 
ATOM   1863 C CG2 . VAL   B 2 296 ? 145.350 118.448 130.745 1.00 64.33  ? 158 VAL   R CG2 1 
ATOM   1864 N N   . GLY   B 2 297 ? 142.138 121.325 132.386 1.00 51.23  ? 159 GLY   R N   1 
ATOM   1865 C CA  . GLY   B 2 297 ? 140.870 121.698 132.976 1.00 46.25  ? 159 GLY   R CA  1 
ATOM   1866 C C   . GLY   B 2 297 ? 140.251 122.978 132.473 1.00 52.77  ? 159 GLY   R C   1 
ATOM   1867 O O   . GLY   B 2 297 ? 139.083 123.241 132.771 1.00 61.82  ? 159 GLY   R O   1 
ATOM   1868 N N   . VAL   B 2 298 ? 140.989 123.789 131.717 1.00 51.68  ? 160 VAL   R N   1 
ATOM   1869 C CA  . VAL   B 2 298 ? 140.437 125.040 131.212 1.00 44.26  ? 160 VAL   R CA  1 
ATOM   1870 C C   . VAL   B 2 298 ? 140.441 125.056 129.689 1.00 53.72  ? 160 VAL   R C   1 
ATOM   1871 O O   . VAL   B 2 298 ? 139.383 125.155 129.059 1.00 55.89  ? 160 VAL   R O   1 
ATOM   1872 C CB  . VAL   B 2 298 ? 141.216 126.245 131.768 1.00 42.76  ? 160 VAL   R CB  1 
ATOM   1873 C CG1 . VAL   B 2 298 ? 140.812 127.518 131.047 1.00 43.80  ? 160 VAL   R CG1 1 
ATOM   1874 C CG2 . VAL   B 2 298 ? 140.986 126.379 133.261 1.00 46.00  ? 160 VAL   R CG2 1 
ATOM   1875 N N   . TRP   B 2 299 ? 141.627 124.956 129.086 1.00 46.64  ? 161 TRP   R N   1 
ATOM   1876 C CA  . TRP   B 2 299 ? 141.754 125.274 127.670 1.00 41.02  ? 161 TRP   R CA  1 
ATOM   1877 C C   . TRP   B 2 299 ? 141.178 124.181 126.778 1.00 54.75  ? 161 TRP   R C   1 
ATOM   1878 O O   . TRP   B 2 299 ? 140.491 124.484 125.797 1.00 62.18  ? 161 TRP   R O   1 
ATOM   1879 C CB  . TRP   B 2 299 ? 143.219 125.534 127.328 1.00 39.64  ? 161 TRP   R CB  1 
ATOM   1880 C CG  . TRP   B 2 299 ? 143.724 126.842 127.860 1.00 44.26  ? 161 TRP   R CG  1 
ATOM   1881 C CD1 . TRP   B 2 299 ? 144.649 127.022 128.842 1.00 45.93  ? 161 TRP   R CD1 1 
ATOM   1882 C CD2 . TRP   B 2 299 ? 143.326 128.152 127.440 1.00 49.15  ? 161 TRP   R CD2 1 
ATOM   1883 N NE1 . TRP   B 2 299 ? 144.854 128.361 129.062 1.00 41.88  ? 161 TRP   R NE1 1 
ATOM   1884 C CE2 . TRP   B 2 299 ? 144.054 129.076 128.212 1.00 43.94  ? 161 TRP   R CE2 1 
ATOM   1885 C CE3 . TRP   B 2 299 ? 142.426 128.633 126.486 1.00 53.09  ? 161 TRP   R CE3 1 
ATOM   1886 C CZ2 . TRP   B 2 299 ? 143.910 130.450 128.060 1.00 46.00  ? 161 TRP   R CZ2 1 
ATOM   1887 C CZ3 . TRP   B 2 299 ? 142.285 129.998 126.337 1.00 45.60  ? 161 TRP   R CZ3 1 
ATOM   1888 C CH2 . TRP   B 2 299 ? 143.023 130.890 127.119 1.00 44.62  ? 161 TRP   R CH2 1 
ATOM   1889 N N   . ILE   B 2 300 ? 141.444 122.912 127.092 1.00 58.99  ? 162 ILE   R N   1 
ATOM   1890 C CA  . ILE   B 2 300 ? 140.939 121.823 126.252 1.00 54.51  ? 162 ILE   R CA  1 
ATOM   1891 C C   . ILE   B 2 300 ? 139.414 121.766 126.234 1.00 55.77  ? 162 ILE   R C   1 
ATOM   1892 O O   . ILE   B 2 300 ? 138.837 121.663 125.141 1.00 56.04  ? 162 ILE   R O   1 
ATOM   1893 C CB  . ILE   B 2 300 ? 141.587 120.489 126.663 1.00 52.80  ? 162 ILE   R CB  1 
ATOM   1894 C CG1 . ILE   B 2 300 ? 142.978 120.366 126.042 1.00 50.24  ? 162 ILE   R CG1 1 
ATOM   1895 C CG2 . ILE   B 2 300 ? 140.720 119.317 126.239 1.00 49.93  ? 162 ILE   R CG2 1 
ATOM   1896 C CD1 . ILE   B 2 300 ? 143.725 119.126 126.466 1.00 55.38  ? 162 ILE   R CD1 1 
ATOM   1897 N N   . PRO   B 2 301 ? 138.707 121.810 127.373 1.00 56.46  ? 163 PRO   R N   1 
ATOM   1898 C CA  . PRO   B 2 301 ? 137.239 121.909 127.285 1.00 51.78  ? 163 PRO   R CA  1 
ATOM   1899 C C   . PRO   B 2 301 ? 136.772 123.173 126.587 1.00 59.02  ? 163 PRO   R C   1 
ATOM   1900 O O   . PRO   B 2 301 ? 135.767 123.142 125.865 1.00 66.12  ? 163 PRO   R O   1 
ATOM   1901 C CB  . PRO   B 2 301 ? 136.795 121.866 128.754 1.00 49.56  ? 163 PRO   R CB  1 
ATOM   1902 C CG  . PRO   B 2 301 ? 137.923 121.235 129.476 1.00 51.54  ? 163 PRO   R CG  1 
ATOM   1903 C CD  . PRO   B 2 301 ? 139.150 121.708 128.772 1.00 52.90  ? 163 PRO   R CD  1 
ATOM   1904 N N   . ALA   B 2 302 ? 137.485 124.288 126.771 1.00 52.09  ? 164 ALA   R N   1 
ATOM   1905 C CA  . ALA   B 2 302 ? 137.113 125.525 126.092 1.00 43.81  ? 164 ALA   R CA  1 
ATOM   1906 C C   . ALA   B 2 302 ? 137.213 125.372 124.581 1.00 53.44  ? 164 ALA   R C   1 
ATOM   1907 O O   . ALA   B 2 302 ? 136.324 125.814 123.845 1.00 66.24  ? 164 ALA   R O   1 
ATOM   1908 C CB  . ALA   B 2 302 ? 137.990 126.679 126.573 1.00 32.34  ? 164 ALA   R CB  1 
ATOM   1909 N N   . LEU   B 2 303 ? 138.286 124.743 124.099 1.00 42.80  ? 165 LEU   R N   1 
ATOM   1910 C CA  . LEU   B 2 303 ? 138.417 124.504 122.667 1.00 45.49  ? 165 LEU   R CA  1 
ATOM   1911 C C   . LEU   B 2 303 ? 137.377 123.506 122.173 1.00 48.57  ? 165 LEU   R C   1 
ATOM   1912 O O   . LEU   B 2 303 ? 136.794 123.690 121.099 1.00 59.36  ? 165 LEU   R O   1 
ATOM   1913 C CB  . LEU   B 2 303 ? 139.826 124.012 122.345 1.00 48.21  ? 165 LEU   R CB  1 
ATOM   1914 C CG  . LEU   B 2 303 ? 140.925 125.071 122.399 1.00 52.55  ? 165 LEU   R CG  1 
ATOM   1915 C CD1 . LEU   B 2 303 ? 142.290 124.428 122.237 1.00 56.71  ? 165 LEU   R CD1 1 
ATOM   1916 C CD2 . LEU   B 2 303 ? 140.698 126.132 121.338 1.00 52.07  ? 165 LEU   R CD2 1 
ATOM   1917 N N   . LEU   B 2 304 ? 137.129 122.445 122.942 1.00 50.44  ? 166 LEU   R N   1 
ATOM   1918 C CA  . LEU   B 2 304 ? 136.185 121.420 122.513 1.00 60.64  ? 166 LEU   R CA  1 
ATOM   1919 C C   . LEU   B 2 304 ? 134.748 121.919 122.506 1.00 59.72  ? 166 LEU   R C   1 
ATOM   1920 O O   . LEU   B 2 304 ? 133.912 121.350 121.797 1.00 60.21  ? 166 LEU   R O   1 
ATOM   1921 C CB  . LEU   B 2 304 ? 136.306 120.188 123.409 1.00 62.66  ? 166 LEU   R CB  1 
ATOM   1922 C CG  . LEU   B 2 304 ? 137.565 119.337 123.228 1.00 60.93  ? 166 LEU   R CG  1 
ATOM   1923 C CD1 . LEU   B 2 304 ? 137.573 118.179 124.210 1.00 57.19  ? 166 LEU   R CD1 1 
ATOM   1924 C CD2 . LEU   B 2 304 ? 137.673 118.833 121.799 1.00 56.48  ? 166 LEU   R CD2 1 
ATOM   1925 N N   . LEU   B 2 305 ? 134.439 122.958 123.277 1.00 65.70  ? 167 LEU   R N   1 
ATOM   1926 C CA  . LEU   B 2 305 ? 133.099 123.529 123.278 1.00 62.92  ? 167 LEU   R CA  1 
ATOM   1927 C C   . LEU   B 2 305 ? 132.837 124.433 122.081 1.00 69.74  ? 167 LEU   R C   1 
ATOM   1928 O O   . LEU   B 2 305 ? 131.709 124.913 121.924 1.00 73.47  ? 167 LEU   R O   1 
ATOM   1929 C CB  . LEU   B 2 305 ? 132.861 124.305 124.575 1.00 52.91  ? 167 LEU   R CB  1 
ATOM   1930 C CG  . LEU   B 2 305 ? 132.536 123.451 125.800 1.00 51.33  ? 167 LEU   R CG  1 
ATOM   1931 C CD1 . LEU   B 2 305 ? 132.600 124.279 127.063 1.00 53.87  ? 167 LEU   R CD1 1 
ATOM   1932 C CD2 . LEU   B 2 305 ? 131.172 122.810 125.648 1.00 64.01  ? 167 LEU   R CD2 1 
ATOM   1933 N N   . THR   B 2 306 ? 133.841 124.682 121.242 1.00 62.58  ? 168 THR   R N   1 
ATOM   1934 C CA  . THR   B 2 306 ? 133.685 125.523 120.064 1.00 58.24  ? 168 THR   R CA  1 
ATOM   1935 C C   . THR   B 2 306 ? 133.292 124.742 118.819 1.00 61.12  ? 168 THR   R C   1 
ATOM   1936 O O   . THR   B 2 306 ? 133.193 125.339 117.742 1.00 66.41  ? 168 THR   R O   1 
ATOM   1937 C CB  . THR   B 2 306 ? 134.975 126.292 119.788 1.00 55.30  ? 168 THR   R CB  1 
ATOM   1938 O OG1 . THR   B 2 306 ? 136.024 125.367 119.484 1.00 64.03  ? 168 THR   R OG1 1 
ATOM   1939 C CG2 . THR   B 2 306 ? 135.362 127.107 120.996 1.00 49.84  ? 168 THR   R CG2 1 
ATOM   1940 N N   . ILE   B 2 307 ? 133.086 123.427 118.932 1.00 64.24  ? 169 ILE   R N   1 
ATOM   1941 C CA  . ILE   B 2 307 ? 132.589 122.655 117.789 1.00 64.72  ? 169 ILE   R CA  1 
ATOM   1942 C C   . ILE   B 2 307 ? 131.274 123.214 117.267 1.00 67.64  ? 169 ILE   R C   1 
ATOM   1943 O O   . ILE   B 2 307 ? 131.109 123.303 116.038 1.00 72.69  ? 169 ILE   R O   1 
ATOM   1944 C CB  . ILE   B 2 307 ? 132.517 121.165 118.148 1.00 60.69  ? 169 ILE   R CB  1 
ATOM   1945 C CG1 . ILE   B 2 307 ? 133.922 120.598 118.342 1.00 63.98  ? 169 ILE   R CG1 1 
ATOM   1946 C CG2 . ILE   B 2 307 ? 131.780 120.386 117.074 1.00 62.31  ? 169 ILE   R CG2 1 
ATOM   1947 C CD1 . ILE   B 2 307 ? 133.942 119.244 119.003 1.00 63.13  ? 169 ILE   R CD1 1 
ATOM   1948 N N   . PRO   B 2 308 ? 130.301 123.598 118.102 1.00 66.16  ? 170 PRO   R N   1 
ATOM   1949 C CA  . PRO   B 2 308 ? 129.126 124.295 117.557 1.00 69.98  ? 170 PRO   R CA  1 
ATOM   1950 C C   . PRO   B 2 308 ? 129.474 125.581 116.829 1.00 77.33  ? 170 PRO   R C   1 
ATOM   1951 O O   . PRO   B 2 308 ? 128.769 125.951 115.884 1.00 75.64  ? 170 PRO   R O   1 
ATOM   1952 C CB  . PRO   B 2 308 ? 128.271 124.560 118.802 1.00 69.94  ? 170 PRO   R CB  1 
ATOM   1953 C CG  . PRO   B 2 308 ? 128.659 123.494 119.744 1.00 72.70  ? 170 PRO   R CG  1 
ATOM   1954 C CD  . PRO   B 2 308 ? 130.122 123.291 119.533 1.00 69.60  ? 170 PRO   R CD  1 
ATOM   1955 N N   . ASP   B 2 309 ? 130.538 126.273 117.232 1.00 74.29  ? 171 ASP   R N   1 
ATOM   1956 C CA  . ASP   B 2 309 ? 130.963 127.472 116.521 1.00 68.11  ? 171 ASP   R CA  1 
ATOM   1957 C C   . ASP   B 2 309 ? 131.729 127.162 115.245 1.00 68.56  ? 171 ASP   R C   1 
ATOM   1958 O O   . ASP   B 2 309 ? 131.942 128.069 114.435 1.00 73.92  ? 171 ASP   R O   1 
ATOM   1959 C CB  . ASP   B 2 309 ? 131.816 128.350 117.432 1.00 68.20  ? 171 ASP   R CB  1 
ATOM   1960 C CG  . ASP   B 2 309 ? 130.986 129.103 118.442 1.00 78.34  ? 171 ASP   R CG  1 
ATOM   1961 O OD1 . ASP   B 2 309 ? 129.747 128.954 118.419 1.00 83.33  ? 171 ASP   R OD1 1 
ATOM   1962 O OD2 . ASP   B 2 309 ? 131.566 129.841 119.258 1.00 78.20  ? 171 ASP   R OD2 1 
ATOM   1963 N N   . PHE   B 2 310 ? 132.157 125.917 115.052 1.00 62.31  ? 172 PHE   R N   1 
ATOM   1964 C CA  . PHE   B 2 310 ? 132.703 125.493 113.772 1.00 53.92  ? 172 PHE   R CA  1 
ATOM   1965 C C   . PHE   B 2 310 ? 131.629 124.964 112.838 1.00 59.14  ? 172 PHE   R C   1 
ATOM   1966 O O   . PHE   B 2 310 ? 131.787 125.046 111.616 1.00 71.93  ? 172 PHE   R O   1 
ATOM   1967 C CB  . PHE   B 2 310 ? 133.766 124.412 113.975 1.00 54.01  ? 172 PHE   R CB  1 
ATOM   1968 C CG  . PHE   B 2 310 ? 135.122 124.950 114.313 1.00 59.66  ? 172 PHE   R CG  1 
ATOM   1969 C CD1 . PHE   B 2 310 ? 135.887 125.583 113.354 1.00 60.22  ? 172 PHE   R CD1 1 
ATOM   1970 C CD2 . PHE   B 2 310 ? 135.636 124.812 115.589 1.00 63.50  ? 172 PHE   R CD2 1 
ATOM   1971 C CE1 . PHE   B 2 310 ? 137.137 126.077 113.662 1.00 64.16  ? 172 PHE   R CE1 1 
ATOM   1972 C CE2 . PHE   B 2 310 ? 136.886 125.303 115.903 1.00 62.63  ? 172 PHE   R CE2 1 
ATOM   1973 C CZ  . PHE   B 2 310 ? 137.637 125.936 114.939 1.00 66.95  ? 172 PHE   R CZ  1 
ATOM   1974 N N   . ILE   B 2 311 ? 130.542 124.429 113.384 1.00 56.64  ? 173 ILE   R N   1 
ATOM   1975 C CA  . ILE   B 2 311 ? 129.503 123.830 112.554 1.00 60.68  ? 173 ILE   R CA  1 
ATOM   1976 C C   . ILE   B 2 311 ? 128.423 124.840 112.180 1.00 66.76  ? 173 ILE   R C   1 
ATOM   1977 O O   . ILE   B 2 311 ? 127.991 124.892 111.027 1.00 67.54  ? 173 ILE   R O   1 
ATOM   1978 C CB  . ILE   B 2 311 ? 128.902 122.607 113.273 1.00 61.17  ? 173 ILE   R CB  1 
ATOM   1979 C CG1 . ILE   B 2 311 ? 129.952 121.507 113.425 1.00 60.89  ? 173 ILE   R CG1 1 
ATOM   1980 C CG2 . ILE   B 2 311 ? 127.691 122.080 112.523 1.00 62.92  ? 173 ILE   R CG2 1 
ATOM   1981 C CD1 . ILE   B 2 311 ? 129.408 120.226 114.012 1.00 63.13  ? 173 ILE   R CD1 1 
ATOM   1982 N N   . PHE   B 2 312 ? 127.980 125.663 113.130 1.00 70.63  ? 174 PHE   R N   1 
ATOM   1983 C CA  . PHE   B 2 312 ? 126.778 126.468 112.957 1.00 68.15  ? 174 PHE   R CA  1 
ATOM   1984 C C   . PHE   B 2 312 ? 127.045 127.910 112.549 1.00 74.53  ? 174 PHE   R C   1 
ATOM   1985 O O   . PHE   B 2 312 ? 126.167 128.537 111.949 1.00 75.98  ? 174 PHE   R O   1 
ATOM   1986 C CB  . PHE   B 2 312 ? 125.959 126.464 114.251 1.00 67.31  ? 174 PHE   R CB  1 
ATOM   1987 C CG  . PHE   B 2 312 ? 125.524 125.096 114.685 1.00 70.83  ? 174 PHE   R CG  1 
ATOM   1988 C CD1 . PHE   B 2 312 ? 124.731 124.316 113.865 1.00 70.05  ? 174 PHE   R CD1 1 
ATOM   1989 C CD2 . PHE   B 2 312 ? 125.910 124.590 115.912 1.00 70.18  ? 174 PHE   R CD2 1 
ATOM   1990 C CE1 . PHE   B 2 312 ? 124.328 123.058 114.262 1.00 70.24  ? 174 PHE   R CE1 1 
ATOM   1991 C CE2 . PHE   B 2 312 ? 125.512 123.333 116.313 1.00 67.81  ? 174 PHE   R CE2 1 
ATOM   1992 C CZ  . PHE   B 2 312 ? 124.720 122.566 115.487 1.00 70.61  ? 174 PHE   R CZ  1 
ATOM   1993 N N   . ALA   B 2 313 ? 128.216 128.459 112.860 1.00 71.07  ? 175 ALA   R N   1 
ATOM   1994 C CA  . ALA   B 2 313 ? 128.501 129.846 112.514 1.00 64.04  ? 175 ALA   R CA  1 
ATOM   1995 C C   . ALA   B 2 313 ? 128.532 130.020 111.002 1.00 64.46  ? 175 ALA   R C   1 
ATOM   1996 O O   . ALA   B 2 313 ? 129.323 129.372 110.310 1.00 73.74  ? 175 ALA   R O   1 
ATOM   1997 C CB  . ALA   B 2 313 ? 129.829 130.278 113.130 1.00 61.09  ? 175 ALA   R CB  1 
ATOM   1998 N N   . ASN   B 2 314 ? 127.675 130.900 110.491 1.00 65.76  ? 176 ASN   R N   1 
ATOM   1999 C CA  . ASN   B 2 314 ? 127.559 131.104 109.055 1.00 75.24  ? 176 ASN   R CA  1 
ATOM   2000 C C   . ASN   B 2 314 ? 127.087 132.524 108.783 1.00 79.99  ? 176 ASN   R C   1 
ATOM   2001 O O   . ASN   B 2 314 ? 126.600 133.221 109.676 1.00 79.69  ? 176 ASN   R O   1 
ATOM   2002 C CB  . ASN   B 2 314 ? 126.598 130.094 108.417 1.00 74.79  ? 176 ASN   R CB  1 
ATOM   2003 C CG  . ASN   B 2 314 ? 127.262 128.767 108.117 1.00 77.54  ? 176 ASN   R CG  1 
ATOM   2004 O OD1 . ASN   B 2 314 ? 128.177 128.689 107.299 1.00 78.12  ? 176 ASN   R OD1 1 
ATOM   2005 N ND2 . ASN   B 2 314 ? 126.800 127.712 108.777 1.00 79.22  ? 176 ASN   R ND2 1 
ATOM   2006 N N   . VAL   B 2 315 ? 127.238 132.943 107.529 1.00 80.89  ? 177 VAL   R N   1 
ATOM   2007 C CA  . VAL   B 2 315 ? 126.801 134.256 107.068 1.00 77.61  ? 177 VAL   R CA  1 
ATOM   2008 C C   . VAL   B 2 315 ? 125.533 134.064 106.251 1.00 78.11  ? 177 VAL   R C   1 
ATOM   2009 O O   . VAL   B 2 315 ? 125.530 133.324 105.260 1.00 82.42  ? 177 VAL   R O   1 
ATOM   2010 C CB  . VAL   B 2 315 ? 127.887 134.958 106.240 1.00 76.80  ? 177 VAL   R CB  1 
ATOM   2011 C CG1 . VAL   B 2 315 ? 127.352 136.252 105.659 1.00 79.34  ? 177 VAL   R CG1 1 
ATOM   2012 C CG2 . VAL   B 2 315 ? 129.111 135.223 107.094 1.00 79.70  ? 177 VAL   R CG2 1 
ATOM   2013 N N   . SER   B 2 316 ? 124.458 134.729 106.662 1.00 88.32  ? 178 SER   R N   1 
ATOM   2014 C CA  . SER   B 2 316 ? 123.178 134.600 105.991 1.00 92.13  ? 178 SER   R CA  1 
ATOM   2015 C C   . SER   B 2 316 ? 123.053 135.645 104.885 1.00 95.95  ? 178 SER   R C   1 
ATOM   2016 O O   . SER   B 2 316 ? 123.946 136.465 104.660 1.00 94.83  ? 178 SER   R O   1 
ATOM   2017 C CB  . SER   B 2 316 ? 122.033 134.726 106.993 1.00 90.88  ? 178 SER   R CB  1 
ATOM   2018 O OG  . SER   B 2 316 ? 120.780 134.681 106.335 1.00 94.03  ? 178 SER   R OG  1 
ATOM   2019 N N   . GLU   B 2 317 ? 121.922 135.615 104.187 1.00 111.87 ? 179 GLU   R N   1 
ATOM   2020 C CA  . GLU   B 2 317 ? 121.647 136.511 103.069 1.00 109.00 ? 179 GLU   R CA  1 
ATOM   2021 C C   . GLU   B 2 317 ? 120.320 137.223 103.283 1.00 109.08 ? 179 GLU   R C   1 
ATOM   2022 O O   . GLU   B 2 317 ? 119.441 137.237 102.418 1.00 111.14 ? 179 GLU   R O   1 
ATOM   2023 C CB  . GLU   B 2 317 ? 121.654 135.752 101.744 1.00 109.37 ? 179 GLU   R CB  1 
ATOM   2024 C CG  . GLU   B 2 317 ? 122.032 136.608 100.543 1.00 111.63 ? 179 GLU   R CG  1 
ATOM   2025 C CD  . GLU   B 2 317 ? 120.826 137.132 99.789  1.00 114.43 ? 179 GLU   R CD  1 
ATOM   2026 O OE1 . GLU   B 2 317 ? 119.814 136.405 99.701  1.00 114.50 ? 179 GLU   R OE1 1 
ATOM   2027 O OE2 . GLU   B 2 317 ? 120.887 138.275 99.289  1.00 112.85 ? 179 GLU   R OE2 1 
ATOM   2028 N N   . ALA   B 2 318 ? 120.150 137.806 104.467 1.00 112.92 ? 180 ALA   R N   1 
ATOM   2029 C CA  . ALA   B 2 318 ? 118.953 138.579 104.758 1.00 113.78 ? 180 ALA   R CA  1 
ATOM   2030 C C   . ALA   B 2 318 ? 118.810 139.734 103.770 1.00 116.93 ? 180 ALA   R C   1 
ATOM   2031 O O   . ALA   B 2 318 ? 119.758 140.125 103.083 1.00 116.60 ? 180 ALA   R O   1 
ATOM   2032 C CB  . ALA   B 2 318 ? 118.992 139.110 106.190 1.00 112.91 ? 180 ALA   R CB  1 
ATOM   2033 N N   . ASP   B 2 319 ? 117.599 140.277 103.696 1.00 123.90 ? 181 ASP   R N   1 
ATOM   2034 C CA  . ASP   B 2 319 ? 117.315 141.329 102.730 1.00 122.85 ? 181 ASP   R CA  1 
ATOM   2035 C C   . ASP   B 2 319 ? 118.077 142.602 103.077 1.00 121.34 ? 181 ASP   R C   1 
ATOM   2036 O O   . ASP   B 2 319 ? 118.071 143.049 104.228 1.00 121.18 ? 181 ASP   R O   1 
ATOM   2037 C CB  . ASP   B 2 319 ? 115.815 141.606 102.674 1.00 122.68 ? 181 ASP   R CB  1 
ATOM   2038 C CG  . ASP   B 2 319 ? 115.055 140.537 101.914 1.00 123.12 ? 181 ASP   R CG  1 
ATOM   2039 O OD1 . ASP   B 2 319 ? 115.708 139.695 101.262 1.00 124.50 ? 181 ASP   R OD1 1 
ATOM   2040 O OD2 . ASP   B 2 319 ? 113.807 140.539 101.967 1.00 122.75 ? 181 ASP   R OD2 1 
ATOM   2041 N N   . ASP   B 2 320 ? 118.765 143.156 102.076 1.00 117.60 ? 182 ASP   R N   1 
ATOM   2042 C CA  . ASP   B 2 320 ? 119.412 144.464 102.132 1.00 120.10 ? 182 ASP   R CA  1 
ATOM   2043 C C   . ASP   B 2 320 ? 120.653 144.465 103.021 1.00 121.92 ? 182 ASP   R C   1 
ATOM   2044 O O   . ASP   B 2 320 ? 121.378 145.465 103.068 1.00 123.28 ? 182 ASP   R O   1 
ATOM   2045 C CB  . ASP   B 2 320 ? 118.420 145.533 102.607 1.00 119.89 ? 182 ASP   R CB  1 
ATOM   2046 C CG  . ASP   B 2 320 ? 118.832 146.937 102.205 1.00 121.01 ? 182 ASP   R CG  1 
ATOM   2047 O OD1 . ASP   B 2 320 ? 119.848 147.084 101.493 1.00 122.64 ? 182 ASP   R OD1 1 
ATOM   2048 O OD2 . ASP   B 2 320 ? 118.139 147.896 102.604 1.00 120.29 ? 182 ASP   R OD2 1 
ATOM   2049 N N   . ARG   B 2 321 ? 120.925 143.360 103.713 1.00 106.17 ? 183 ARG   R N   1 
ATOM   2050 C CA  . ARG   B 2 321 ? 122.102 143.297 104.569 1.00 103.48 ? 183 ARG   R CA  1 
ATOM   2051 C C   . ARG   B 2 321 ? 122.395 141.849 104.935 1.00 103.77 ? 183 ARG   R C   1 
ATOM   2052 O O   . ARG   B 2 321 ? 121.484 141.026 105.047 1.00 106.65 ? 183 ARG   R O   1 
ATOM   2053 C CB  . ARG   B 2 321 ? 121.924 144.139 105.838 1.00 99.60  ? 183 ARG   R CB  1 
ATOM   2054 C CG  . ARG   B 2 321 ? 120.938 143.573 106.844 1.00 100.77 ? 183 ARG   R CG  1 
ATOM   2055 C CD  . ARG   B 2 321 ? 120.835 144.471 108.065 1.00 101.71 ? 183 ARG   R CD  1 
ATOM   2056 N NE  . ARG   B 2 321 ? 122.146 144.901 108.536 1.00 103.82 ? 183 ARG   R NE  1 
ATOM   2057 C CZ  . ARG   B 2 321 ? 122.875 144.246 109.429 1.00 104.31 ? 183 ARG   R CZ  1 
ATOM   2058 N NH1 . ARG   B 2 321 ? 122.451 143.118 109.974 1.00 103.69 ? 183 ARG   R NH1 1 
ATOM   2059 N NH2 . ARG   B 2 321 ? 124.059 144.735 109.785 1.00 101.18 ? 183 ARG   R NH2 1 
ATOM   2060 N N   . TYR   B 2 322 ? 123.678 141.556 105.124 1.00 96.33  ? 184 TYR   R N   1 
ATOM   2061 C CA  . TYR   B 2 322 ? 124.126 140.244 105.564 1.00 93.95  ? 184 TYR   R CA  1 
ATOM   2062 C C   . TYR   B 2 322 ? 124.187 140.184 107.086 1.00 94.26  ? 184 TYR   R C   1 
ATOM   2063 O O   . TYR   B 2 322 ? 124.348 141.198 107.768 1.00 97.08  ? 184 TYR   R O   1 
ATOM   2064 C CB  . TYR   B 2 322 ? 125.497 139.916 104.972 1.00 94.07  ? 184 TYR   R CB  1 
ATOM   2065 C CG  . TYR   B 2 322 ? 125.511 139.833 103.464 1.00 96.75  ? 184 TYR   R CG  1 
ATOM   2066 C CD1 . TYR   B 2 322 ? 124.420 139.334 102.767 1.00 99.59  ? 184 TYR   R CD1 1 
ATOM   2067 C CD2 . TYR   B 2 322 ? 126.617 140.248 102.737 1.00 97.31  ? 184 TYR   R CD2 1 
ATOM   2068 C CE1 . TYR   B 2 322 ? 124.428 139.255 101.388 1.00 97.43  ? 184 TYR   R CE1 1 
ATOM   2069 C CE2 . TYR   B 2 322 ? 126.635 140.173 101.359 1.00 98.42  ? 184 TYR   R CE2 1 
ATOM   2070 C CZ  . TYR   B 2 322 ? 125.538 139.675 100.690 1.00 98.11  ? 184 TYR   R CZ  1 
ATOM   2071 O OH  . TYR   B 2 322 ? 125.551 139.598 99.317  1.00 100.09 ? 184 TYR   R OH  1 
ATOM   2072 N N   . ILE   B 2 323 ? 124.052 138.971 107.617 1.00 90.90  ? 185 ILE   R N   1 
ATOM   2073 C CA  . ILE   B 2 323 ? 124.045 138.732 109.056 1.00 90.92  ? 185 ILE   R CA  1 
ATOM   2074 C C   . ILE   B 2 323 ? 125.010 137.599 109.371 1.00 91.67  ? 185 ILE   R C   1 
ATOM   2075 O O   . ILE   B 2 323 ? 124.937 136.528 108.760 1.00 97.02  ? 185 ILE   R O   1 
ATOM   2076 C CB  . ILE   B 2 323 ? 122.633 138.394 109.570 1.00 92.82  ? 185 ILE   R CB  1 
ATOM   2077 C CG1 . ILE   B 2 323 ? 121.660 139.531 109.256 1.00 95.00  ? 185 ILE   R CG1 1 
ATOM   2078 C CG2 . ILE   B 2 323 ? 122.662 138.116 111.062 1.00 93.12  ? 185 ILE   R CG2 1 
ATOM   2079 C CD1 . ILE   B 2 323 ? 120.280 139.333 109.843 1.00 93.69  ? 185 ILE   R CD1 1 
ATOM   2080 N N   . CYS   B 2 324 ? 125.909 137.835 110.323 1.00 81.04  ? 186 CYS   R N   1 
ATOM   2081 C CA  . CYS   B 2 324 ? 126.829 136.819 110.827 1.00 79.88  ? 186 CYS   R CA  1 
ATOM   2082 C C   . CYS   B 2 324 ? 126.308 136.323 112.169 1.00 84.18  ? 186 CYS   R C   1 
ATOM   2083 O O   . CYS   B 2 324 ? 126.386 137.038 113.172 1.00 93.48  ? 186 CYS   R O   1 
ATOM   2084 C CB  . CYS   B 2 324 ? 128.241 137.389 110.958 1.00 84.97  ? 186 CYS   R CB  1 
ATOM   2085 S SG  . CYS   B 2 324 ? 129.444 136.376 111.875 1.00 96.69  ? 186 CYS   R SG  1 
ATOM   2086 N N   . ASP   B 2 325 ? 125.775 135.104 112.188 1.00 80.09  ? 187 ASP   R N   1 
ATOM   2087 C CA  . ASP   B 2 325 ? 125.230 134.546 113.417 1.00 80.59  ? 187 ASP   R CA  1 
ATOM   2088 C C   . ASP   B 2 325 ? 125.161 133.032 113.282 1.00 81.68  ? 187 ASP   R C   1 
ATOM   2089 O O   . ASP   B 2 325 ? 125.214 132.486 112.178 1.00 85.15  ? 187 ASP   R O   1 
ATOM   2090 C CB  . ASP   B 2 325 ? 123.847 135.126 113.728 1.00 79.96  ? 187 ASP   R CB  1 
ATOM   2091 C CG  . ASP   B 2 325 ? 123.428 134.897 115.166 1.00 82.73  ? 187 ASP   R CG  1 
ATOM   2092 O OD1 . ASP   B 2 325 ? 124.218 134.303 115.930 1.00 79.81  ? 187 ASP   R OD1 1 
ATOM   2093 O OD2 . ASP   B 2 325 ? 122.308 135.308 115.532 1.00 85.28  ? 187 ASP   R OD2 1 
ATOM   2094 N N   . ARG   B 2 326 ? 125.046 132.363 114.426 1.00 74.85  ? 188 ARG   R N   1 
ATOM   2095 C CA  . ARG   B 2 326 ? 124.927 130.911 114.462 1.00 72.19  ? 188 ARG   R CA  1 
ATOM   2096 C C   . ARG   B 2 326 ? 123.518 130.498 114.058 1.00 73.96  ? 188 ARG   R C   1 
ATOM   2097 O O   . ARG   B 2 326 ? 122.536 131.038 114.574 1.00 77.63  ? 188 ARG   R O   1 
ATOM   2098 C CB  . ARG   B 2 326 ? 125.256 130.396 115.861 1.00 69.98  ? 188 ARG   R CB  1 
ATOM   2099 C CG  . ARG   B 2 326 ? 126.660 130.754 116.315 1.00 75.48  ? 188 ARG   R CG  1 
ATOM   2100 C CD  . ARG   B 2 326 ? 126.908 130.400 117.770 1.00 71.05  ? 188 ARG   R CD  1 
ATOM   2101 N NE  . ARG   B 2 326 ? 126.313 129.127 118.156 1.00 71.07  ? 188 ARG   R NE  1 
ATOM   2102 C CZ  . ARG   B 2 326 ? 126.791 128.343 119.113 1.00 77.27  ? 188 ARG   R CZ  1 
ATOM   2103 N NH1 . ARG   B 2 326 ? 127.877 128.669 119.794 1.00 76.05  ? 188 ARG   R NH1 1 
ATOM   2104 N NH2 . ARG   B 2 326 ? 126.160 127.209 119.398 1.00 80.51  ? 188 ARG   R NH2 1 
ATOM   2105 N N   . PHE   B 2 327 ? 123.415 129.541 113.141 1.00 76.64  ? 189 PHE   R N   1 
ATOM   2106 C CA  . PHE   B 2 327 ? 122.129 129.117 112.591 1.00 78.41  ? 189 PHE   R CA  1 
ATOM   2107 C C   . PHE   B 2 327 ? 121.899 127.645 112.920 1.00 77.57  ? 189 PHE   R C   1 
ATOM   2108 O O   . PHE   B 2 327 ? 122.418 126.758 112.237 1.00 76.16  ? 189 PHE   R O   1 
ATOM   2109 C CB  . PHE   B 2 327 ? 122.072 129.368 111.088 1.00 79.32  ? 189 PHE   R CB  1 
ATOM   2110 C CG  . PHE   B 2 327 ? 121.748 130.788 110.729 1.00 79.03  ? 189 PHE   R CG  1 
ATOM   2111 C CD1 . PHE   B 2 327 ? 120.435 131.219 110.674 1.00 80.68  ? 189 PHE   R CD1 1 
ATOM   2112 C CD2 . PHE   B 2 327 ? 122.757 131.694 110.458 1.00 80.49  ? 189 PHE   R CD2 1 
ATOM   2113 C CE1 . PHE   B 2 327 ? 120.134 132.527 110.352 1.00 83.29  ? 189 PHE   R CE1 1 
ATOM   2114 C CE2 . PHE   B 2 327 ? 122.463 133.003 110.135 1.00 81.86  ? 189 PHE   R CE2 1 
ATOM   2115 C CZ  . PHE   B 2 327 ? 121.150 133.419 110.083 1.00 82.79  ? 189 PHE   R CZ  1 
ATOM   2116 N N   . TYR   B 2 328 ? 121.116 127.396 113.963 1.00 79.18  ? 190 TYR   R N   1 
ATOM   2117 C CA  . TYR   B 2 328 ? 120.739 126.051 114.355 1.00 77.39  ? 190 TYR   R CA  1 
ATOM   2118 C C   . TYR   B 2 328 ? 119.580 125.547 113.502 1.00 81.99  ? 190 TYR   R C   1 
ATOM   2119 O O   . TYR   B 2 328 ? 118.876 126.335 112.866 1.00 87.12  ? 190 TYR   R O   1 
ATOM   2120 C CB  . TYR   B 2 328 ? 120.347 126.027 115.827 1.00 73.69  ? 190 TYR   R CB  1 
ATOM   2121 C CG  . TYR   B 2 328 ? 121.286 126.787 116.726 1.00 73.87  ? 190 TYR   R CG  1 
ATOM   2122 C CD1 . TYR   B 2 328 ? 122.466 126.215 117.170 1.00 74.57  ? 190 TYR   R CD1 1 
ATOM   2123 C CD2 . TYR   B 2 328 ? 120.989 128.076 117.136 1.00 77.85  ? 190 TYR   R CD2 1 
ATOM   2124 C CE1 . TYR   B 2 328 ? 123.324 126.906 117.995 1.00 75.25  ? 190 TYR   R CE1 1 
ATOM   2125 C CE2 . TYR   B 2 328 ? 121.840 128.775 117.961 1.00 78.23  ? 190 TYR   R CE2 1 
ATOM   2126 C CZ  . TYR   B 2 328 ? 123.007 128.186 118.387 1.00 75.50  ? 190 TYR   R CZ  1 
ATOM   2127 O OH  . TYR   B 2 328 ? 123.857 128.884 119.209 1.00 80.76  ? 190 TYR   R OH  1 
ATOM   2128 N N   . PRO   B 2 329 ? 119.371 124.227 113.457 1.00 83.57  ? 191 PRO   R N   1 
ATOM   2129 C CA  . PRO   B 2 329 ? 118.207 123.705 112.720 1.00 86.46  ? 191 PRO   R CA  1 
ATOM   2130 C C   . PRO   B 2 329 ? 116.872 124.237 113.216 1.00 88.99  ? 191 PRO   R C   1 
ATOM   2131 O O   . PRO   B 2 329 ? 115.971 124.471 112.400 1.00 87.86  ? 191 PRO   R O   1 
ATOM   2132 C CB  . PRO   B 2 329 ? 118.328 122.189 112.918 1.00 85.04  ? 191 PRO   R CB  1 
ATOM   2133 C CG  . PRO   B 2 329 ? 119.783 121.961 113.120 1.00 86.35  ? 191 PRO   R CG  1 
ATOM   2134 C CD  . PRO   B 2 329 ? 120.283 123.152 113.881 1.00 82.74  ? 191 PRO   R CD  1 
ATOM   2135 N N   . ASN   B 2 330 ? 116.710 124.435 114.520 1.00 95.41  ? 192 ASN   R N   1 
ATOM   2136 C CA  . ASN   B 2 330 ? 115.461 124.967 115.060 1.00 96.19  ? 192 ASN   R CA  1 
ATOM   2137 C C   . ASN   B 2 330 ? 115.735 125.554 116.441 1.00 94.38  ? 192 ASN   R C   1 
ATOM   2138 O O   . ASN   B 2 330 ? 116.890 125.684 116.863 1.00 95.98  ? 192 ASN   R O   1 
ATOM   2139 C CB  . ASN   B 2 330 ? 114.373 123.888 115.095 1.00 94.49  ? 192 ASN   R CB  1 
ATOM   2140 C CG  . ASN   B 2 330 ? 114.842 122.609 115.748 1.00 92.54  ? 192 ASN   R CG  1 
ATOM   2141 O OD1 . ASN   B 2 330 ? 115.149 122.583 116.937 1.00 90.46  ? 192 ASN   R OD1 1 
ATOM   2142 N ND2 . ASN   B 2 330 ? 114.897 121.535 114.970 1.00 93.31  ? 192 ASN   R ND2 1 
ATOM   2143 N N   . ASP   B 2 331 ? 114.662 125.912 117.150 1.00 94.16  ? 193 ASP   R N   1 
ATOM   2144 C CA  . ASP   B 2 331 ? 114.782 126.593 118.435 1.00 96.55  ? 193 ASP   R CA  1 
ATOM   2145 C C   . ASP   B 2 331 ? 115.171 125.661 119.574 1.00 94.04  ? 193 ASP   R C   1 
ATOM   2146 O O   . ASP   B 2 331 ? 115.616 126.143 120.623 1.00 96.09  ? 193 ASP   R O   1 
ATOM   2147 C CB  . ASP   B 2 331 ? 113.468 127.295 118.781 1.00 97.70  ? 193 ASP   R CB  1 
ATOM   2148 C CG  . ASP   B 2 331 ? 112.957 128.164 117.649 1.00 98.83  ? 193 ASP   R CG  1 
ATOM   2149 O OD1 . ASP   B 2 331 ? 113.788 128.782 116.951 1.00 98.13  ? 193 ASP   R OD1 1 
ATOM   2150 O OD2 . ASP   B 2 331 ? 111.724 128.229 117.457 1.00 97.98  ? 193 ASP   R OD2 1 
ATOM   2151 N N   . LEU   B 2 332 ? 115.008 124.348 119.403 1.00 85.13  ? 194 LEU   R N   1 
ATOM   2152 C CA  . LEU   B 2 332 ? 115.389 123.421 120.461 1.00 88.88  ? 194 LEU   R CA  1 
ATOM   2153 C C   . LEU   B 2 332 ? 116.884 123.501 120.741 1.00 90.92  ? 194 LEU   R C   1 
ATOM   2154 O O   . LEU   B 2 332 ? 117.307 123.515 121.904 1.00 91.64  ? 194 LEU   R O   1 
ATOM   2155 C CB  . LEU   B 2 332 ? 114.979 121.999 120.083 1.00 90.70  ? 194 LEU   R CB  1 
ATOM   2156 C CG  . LEU   B 2 332 ? 115.197 120.910 121.133 1.00 89.75  ? 194 LEU   R CG  1 
ATOM   2157 C CD1 . LEU   B 2 332 ? 114.284 121.134 122.326 1.00 89.80  ? 194 LEU   R CD1 1 
ATOM   2158 C CD2 . LEU   B 2 332 ? 114.963 119.535 120.527 1.00 88.19  ? 194 LEU   R CD2 1 
ATOM   2159 N N   . TRP   B 2 333 ? 117.701 123.567 119.686 1.00 85.11  ? 195 TRP   R N   1 
ATOM   2160 C CA  . TRP   B 2 333 ? 119.130 123.786 119.875 1.00 82.59  ? 195 TRP   R CA  1 
ATOM   2161 C C   . TRP   B 2 333 ? 119.408 125.131 120.526 1.00 79.24  ? 195 TRP   R C   1 
ATOM   2162 O O   . TRP   B 2 333 ? 120.344 125.246 121.322 1.00 81.64  ? 195 TRP   R O   1 
ATOM   2163 C CB  . TRP   B 2 333 ? 119.871 123.680 118.543 1.00 82.86  ? 195 TRP   R CB  1 
ATOM   2164 C CG  . TRP   B 2 333 ? 120.186 122.277 118.123 1.00 85.38  ? 195 TRP   R CG  1 
ATOM   2165 C CD1 . TRP   B 2 333 ? 121.378 121.631 118.270 1.00 83.28  ? 195 TRP   R CD1 1 
ATOM   2166 C CD2 . TRP   B 2 333 ? 119.302 121.347 117.490 1.00 88.56  ? 195 TRP   R CD2 1 
ATOM   2167 N NE1 . TRP   B 2 333 ? 121.291 120.358 117.766 1.00 82.68  ? 195 TRP   R NE1 1 
ATOM   2168 C CE2 . TRP   B 2 333 ? 120.026 120.158 117.283 1.00 87.93  ? 195 TRP   R CE2 1 
ATOM   2169 C CE3 . TRP   B 2 333 ? 117.968 121.403 117.080 1.00 86.31  ? 195 TRP   R CE3 1 
ATOM   2170 C CZ2 . TRP   B 2 333 ? 119.462 119.036 116.683 1.00 87.58  ? 195 TRP   R CZ2 1 
ATOM   2171 C CZ3 . TRP   B 2 333 ? 117.409 120.289 116.485 1.00 86.53  ? 195 TRP   R CZ3 1 
ATOM   2172 C CH2 . TRP   B 2 333 ? 118.155 119.121 116.292 1.00 88.17  ? 195 TRP   R CH2 1 
ATOM   2173 N N   . VAL   B 2 334 ? 118.617 126.156 120.206 1.00 74.56  ? 196 VAL   R N   1 
ATOM   2174 C CA  . VAL   B 2 334 ? 118.811 127.460 120.836 1.00 77.06  ? 196 VAL   R CA  1 
ATOM   2175 C C   . VAL   B 2 334 ? 118.621 127.348 122.342 1.00 78.89  ? 196 VAL   R C   1 
ATOM   2176 O O   . VAL   B 2 334 ? 119.446 127.827 123.129 1.00 79.13  ? 196 VAL   R O   1 
ATOM   2177 C CB  . VAL   B 2 334 ? 117.861 128.505 120.226 1.00 75.15  ? 196 VAL   R CB  1 
ATOM   2178 C CG1 . VAL   B 2 334 ? 118.252 129.899 120.680 1.00 74.25  ? 196 VAL   R CG1 1 
ATOM   2179 C CG2 . VAL   B 2 334 ? 117.878 128.419 118.713 1.00 77.13  ? 196 VAL   R CG2 1 
ATOM   2180 N N   . VAL   B 2 335 ? 117.539 126.689 122.764 1.00 80.48  ? 197 VAL   R N   1 
ATOM   2181 C CA  . VAL   B 2 335 ? 117.278 126.523 124.192 1.00 75.64  ? 197 VAL   R CA  1 
ATOM   2182 C C   . VAL   B 2 335 ? 118.373 125.689 124.846 1.00 77.33  ? 197 VAL   R C   1 
ATOM   2183 O O   . VAL   B 2 335 ? 118.865 126.023 125.932 1.00 80.94  ? 197 VAL   R O   1 
ATOM   2184 C CB  . VAL   B 2 335 ? 115.888 125.899 124.413 1.00 74.89  ? 197 VAL   R CB  1 
ATOM   2185 C CG1 . VAL   B 2 335 ? 115.597 125.773 125.894 1.00 76.41  ? 197 VAL   R CG1 1 
ATOM   2186 C CG2 . VAL   B 2 335 ? 114.818 126.731 123.732 1.00 78.18  ? 197 VAL   R CG2 1 
ATOM   2187 N N   . VAL   B 2 336 ? 118.772 124.592 124.195 1.00 77.89  ? 198 VAL   R N   1 
ATOM   2188 C CA  . VAL   B 2 336 ? 119.770 123.696 124.775 1.00 72.28  ? 198 VAL   R CA  1 
ATOM   2189 C C   . VAL   B 2 336 ? 121.101 124.414 124.955 1.00 72.43  ? 198 VAL   R C   1 
ATOM   2190 O O   . VAL   B 2 336 ? 121.744 124.307 126.006 1.00 70.89  ? 198 VAL   R O   1 
ATOM   2191 C CB  . VAL   B 2 336 ? 119.920 122.435 123.906 1.00 69.34  ? 198 VAL   R CB  1 
ATOM   2192 C CG1 . VAL   B 2 336 ? 121.211 121.711 124.236 1.00 73.41  ? 198 VAL   R CG1 1 
ATOM   2193 C CG2 . VAL   B 2 336 ? 118.727 121.517 124.100 1.00 75.49  ? 198 VAL   R CG2 1 
ATOM   2194 N N   . PHE   B 2 337 ? 121.532 125.164 123.942 1.00 74.35  ? 199 PHE   R N   1 
ATOM   2195 C CA  . PHE   B 2 337 ? 122.814 125.849 124.039 1.00 70.02  ? 199 PHE   R CA  1 
ATOM   2196 C C   . PHE   B 2 337 ? 122.747 127.035 124.989 1.00 71.76  ? 199 PHE   R C   1 
ATOM   2197 O O   . PHE   B 2 337 ? 123.740 127.340 125.653 1.00 76.90  ? 199 PHE   R O   1 
ATOM   2198 C CB  . PHE   B 2 337 ? 123.282 126.283 122.652 1.00 69.18  ? 199 PHE   R CB  1 
ATOM   2199 C CG  . PHE   B 2 337 ? 123.929 125.178 121.869 1.00 70.19  ? 199 PHE   R CG  1 
ATOM   2200 C CD1 . PHE   B 2 337 ? 125.107 124.605 122.306 1.00 71.71  ? 199 PHE   R CD1 1 
ATOM   2201 C CD2 . PHE   B 2 337 ? 123.347 124.699 120.710 1.00 71.83  ? 199 PHE   R CD2 1 
ATOM   2202 C CE1 . PHE   B 2 337 ? 125.698 123.582 121.596 1.00 69.22  ? 199 PHE   R CE1 1 
ATOM   2203 C CE2 . PHE   B 2 337 ? 123.935 123.677 119.996 1.00 72.45  ? 199 PHE   R CE2 1 
ATOM   2204 C CZ  . PHE   B 2 337 ? 125.111 123.119 120.440 1.00 70.75  ? 199 PHE   R CZ  1 
ATOM   2205 N N   . GLN   B 2 338 ? 121.592 127.699 125.094 1.00 70.56  ? 200 GLN   R N   1 
ATOM   2206 C CA  . GLN   B 2 338 ? 121.446 128.739 126.106 1.00 66.69  ? 200 GLN   R CA  1 
ATOM   2207 C C   . GLN   B 2 338 ? 121.578 128.159 127.507 1.00 71.65  ? 200 GLN   R C   1 
ATOM   2208 O O   . GLN   B 2 338 ? 122.259 128.733 128.364 1.00 75.08  ? 200 GLN   R O   1 
ATOM   2209 C CB  . GLN   B 2 338 ? 120.102 129.449 125.946 1.00 69.05  ? 200 GLN   R CB  1 
ATOM   2210 C CG  . GLN   B 2 338 ? 120.124 130.610 124.967 1.00 76.81  ? 200 GLN   R CG  1 
ATOM   2211 C CD  . GLN   B 2 338 ? 118.803 131.349 124.904 1.00 78.89  ? 200 GLN   R CD  1 
ATOM   2212 O OE1 . GLN   B 2 338 ? 117.820 130.940 125.519 1.00 85.25  ? 200 GLN   R OE1 1 
ATOM   2213 N NE2 . GLN   B 2 338 ? 118.773 132.444 124.157 1.00 72.42  ? 200 GLN   R NE2 1 
ATOM   2214 N N   . PHE   B 2 339 ? 120.943 127.010 127.755 1.00 74.49  ? 201 PHE   R N   1 
ATOM   2215 C CA  . PHE   B 2 339 ? 121.040 126.388 129.072 1.00 65.99  ? 201 PHE   R CA  1 
ATOM   2216 C C   . PHE   B 2 339 ? 122.454 125.897 129.355 1.00 61.93  ? 201 PHE   R C   1 
ATOM   2217 O O   . PHE   B 2 339 ? 122.943 126.023 130.482 1.00 69.15  ? 201 PHE   R O   1 
ATOM   2218 C CB  . PHE   B 2 339 ? 120.035 125.244 129.190 1.00 67.52  ? 201 PHE   R CB  1 
ATOM   2219 C CG  . PHE   B 2 339 ? 118.635 125.699 129.497 1.00 76.18  ? 201 PHE   R CG  1 
ATOM   2220 C CD1 . PHE   B 2 339 ? 118.411 126.922 130.109 1.00 74.32  ? 201 PHE   R CD1 1 
ATOM   2221 C CD2 . PHE   B 2 339 ? 117.545 124.912 129.167 1.00 75.78  ? 201 PHE   R CD2 1 
ATOM   2222 C CE1 . PHE   B 2 339 ? 117.127 127.347 130.390 1.00 71.90  ? 201 PHE   R CE1 1 
ATOM   2223 C CE2 . PHE   B 2 339 ? 116.259 125.333 129.445 1.00 75.40  ? 201 PHE   R CE2 1 
ATOM   2224 C CZ  . PHE   B 2 339 ? 116.051 126.552 130.057 1.00 74.49  ? 201 PHE   R CZ  1 
ATOM   2225 N N   . GLN   B 2 340 ? 123.125 125.331 128.349 1.00 62.32  ? 202 GLN   R N   1 
ATOM   2226 C CA  . GLN   B 2 340 ? 124.506 124.895 128.536 1.00 67.31  ? 202 GLN   R CA  1 
ATOM   2227 C C   . GLN   B 2 340 ? 125.425 126.076 128.828 1.00 58.92  ? 202 GLN   R C   1 
ATOM   2228 O O   . GLN   B 2 340 ? 126.315 125.985 129.683 1.00 56.11  ? 202 GLN   R O   1 
ATOM   2229 C CB  . GLN   B 2 340 ? 124.983 124.126 127.303 1.00 63.70  ? 202 GLN   R CB  1 
ATOM   2230 C CG  . GLN   B 2 340 ? 126.436 123.695 127.362 1.00 60.83  ? 202 GLN   R CG  1 
ATOM   2231 C CD  . GLN   B 2 340 ? 127.306 124.455 126.386 1.00 56.50  ? 202 GLN   R CD  1 
ATOM   2232 O OE1 . GLN   B 2 340 ? 126.968 124.591 125.213 1.00 58.40  ? 202 GLN   R OE1 1 
ATOM   2233 N NE2 . GLN   B 2 340 ? 128.432 124.961 126.868 1.00 59.08  ? 202 GLN   R NE2 1 
ATOM   2234 N N   . HIS   B 2 341 ? 125.229 127.189 128.118 1.00 63.97  ? 203 HIS   R N   1 
ATOM   2235 C CA  . HIS   B 2 341 ? 125.985 128.402 128.401 1.00 56.29  ? 203 HIS   R CA  1 
ATOM   2236 C C   . HIS   B 2 341 ? 125.741 128.868 129.827 1.00 53.10  ? 203 HIS   R C   1 
ATOM   2237 O O   . HIS   B 2 341 ? 126.688 129.157 130.566 1.00 59.58  ? 203 HIS   R O   1 
ATOM   2238 C CB  . HIS   B 2 341 ? 125.601 129.489 127.393 1.00 60.95  ? 203 HIS   R CB  1 
ATOM   2239 C CG  . HIS   B 2 341 ? 126.208 130.831 127.668 1.00 65.97  ? 203 HIS   R CG  1 
ATOM   2240 N ND1 . HIS   B 2 341 ? 125.740 131.986 127.081 1.00 62.08  ? 203 HIS   R ND1 1 
ATOM   2241 C CD2 . HIS   B 2 341 ? 127.249 131.202 128.450 1.00 66.38  ? 203 HIS   R CD2 1 
ATOM   2242 C CE1 . HIS   B 2 341 ? 126.460 133.012 127.497 1.00 56.47  ? 203 HIS   R CE1 1 
ATOM   2243 N NE2 . HIS   B 2 341 ? 127.380 132.564 128.330 1.00 60.99  ? 203 HIS   R NE2 1 
ATOM   2244 N N   . ILE   B 2 342 ? 124.472 128.921 130.241 1.00 51.13  ? 204 ILE   R N   1 
ATOM   2245 C CA  . ILE   B 2 342 ? 124.151 129.357 131.597 1.00 55.80  ? 204 ILE   R CA  1 
ATOM   2246 C C   . ILE   B 2 342 ? 124.851 128.470 132.616 1.00 65.74  ? 204 ILE   R C   1 
ATOM   2247 O O   . ILE   B 2 342 ? 125.541 128.961 133.515 1.00 68.05  ? 204 ILE   R O   1 
ATOM   2248 C CB  . ILE   B 2 342 ? 122.627 129.374 131.817 1.00 55.43  ? 204 ILE   R CB  1 
ATOM   2249 C CG1 . ILE   B 2 342 ? 122.005 130.614 131.176 1.00 55.24  ? 204 ILE   R CG1 1 
ATOM   2250 C CG2 . ILE   B 2 342 ? 122.300 129.337 133.300 1.00 54.62  ? 204 ILE   R CG2 1 
ATOM   2251 C CD1 . ILE   B 2 342 ? 120.514 130.506 130.969 1.00 56.35  ? 204 ILE   R CD1 1 
ATOM   2252 N N   . MET   B 2 343 ? 124.720 127.151 132.467 1.00 60.48  ? 205 MET   R N   1 
ATOM   2253 C CA  . MET   B 2 343 ? 125.352 126.213 133.387 1.00 46.46  ? 205 MET   R CA  1 
ATOM   2254 C C   . MET   B 2 343 ? 126.854 126.439 133.453 1.00 51.11  ? 205 MET   R C   1 
ATOM   2255 O O   . MET   B 2 343 ? 127.360 126.912 134.475 1.00 59.52  ? 205 MET   R O   1 
ATOM   2256 C CB  . MET   B 2 343 ? 125.065 124.770 132.973 1.00 49.28  ? 205 MET   R CB  1 
ATOM   2257 C CG  . MET   B 2 343 ? 123.620 124.344 133.135 1.00 61.60  ? 205 MET   R CG  1 
ATOM   2258 S SD  . MET   B 2 343 ? 123.078 124.359 134.850 1.00 79.11  ? 205 MET   R SD  1 
ATOM   2259 C CE  . MET   B 2 343 ? 124.012 122.982 135.507 1.00 54.97  ? 205 MET   R CE  1 
ATOM   2260 N N   . VAL   B 2 344 ? 127.550 126.182 132.343 1.00 58.04  ? 206 VAL   R N   1 
ATOM   2261 C CA  . VAL   B 2 344 ? 129.008 126.174 132.342 1.00 57.58  ? 206 VAL   R CA  1 
ATOM   2262 C C   . VAL   B 2 344 ? 129.605 127.546 132.639 1.00 54.73  ? 206 VAL   R C   1 
ATOM   2263 O O   . VAL   B 2 344 ? 130.746 127.625 133.108 1.00 52.31  ? 206 VAL   R O   1 
ATOM   2264 C CB  . VAL   B 2 344 ? 129.514 125.621 130.994 1.00 58.21  ? 206 VAL   R CB  1 
ATOM   2265 C CG1 . VAL   B 2 344 ? 131.023 125.466 130.993 1.00 49.25  ? 206 VAL   R CG1 1 
ATOM   2266 C CG2 . VAL   B 2 344 ? 128.858 124.284 130.698 1.00 57.60  ? 206 VAL   R CG2 1 
ATOM   2267 N N   . GLY   B 2 345 ? 128.874 128.636 132.408 1.00 53.71  ? 207 GLY   R N   1 
ATOM   2268 C CA  . GLY   B 2 345 ? 129.444 129.945 132.644 1.00 45.75  ? 207 GLY   R CA  1 
ATOM   2269 C C   . GLY   B 2 345 ? 129.003 130.633 133.918 1.00 49.82  ? 207 GLY   R C   1 
ATOM   2270 O O   . GLY   B 2 345 ? 129.623 131.621 134.320 1.00 60.75  ? 207 GLY   R O   1 
ATOM   2271 N N   . LEU   B 2 346 ? 127.942 130.150 134.564 1.00 46.15  ? 208 LEU   R N   1 
ATOM   2272 C CA  . LEU   B 2 346 ? 127.451 130.779 135.781 1.00 47.18  ? 208 LEU   R CA  1 
ATOM   2273 C C   . LEU   B 2 346 ? 127.389 129.830 136.966 1.00 52.84  ? 208 LEU   R C   1 
ATOM   2274 O O   . LEU   B 2 346 ? 127.839 130.188 138.059 1.00 61.43  ? 208 LEU   R O   1 
ATOM   2275 C CB  . LEU   B 2 346 ? 126.061 131.387 135.529 1.00 49.81  ? 208 LEU   R CB  1 
ATOM   2276 C CG  . LEU   B 2 346 ? 125.440 132.200 136.668 1.00 56.00  ? 208 LEU   R CG  1 
ATOM   2277 C CD1 . LEU   B 2 346 ? 126.187 133.507 136.868 1.00 51.63  ? 208 LEU   R CD1 1 
ATOM   2278 C CD2 . LEU   B 2 346 ? 123.968 132.461 136.403 1.00 54.74  ? 208 LEU   R CD2 1 
ATOM   2279 N N   . ILE   B 2 347 ? 126.841 128.628 136.791 1.00 48.44  ? 209 ILE   R N   1 
ATOM   2280 C CA  . ILE   B 2 347 ? 126.424 127.828 137.937 1.00 39.99  ? 209 ILE   R CA  1 
ATOM   2281 C C   . ILE   B 2 347 ? 127.570 126.976 138.465 1.00 50.05  ? 209 ILE   R C   1 
ATOM   2282 O O   . ILE   B 2 347 ? 127.923 127.071 139.644 1.00 64.92  ? 209 ILE   R O   1 
ATOM   2283 C CB  . ILE   B 2 347 ? 125.203 126.962 137.585 1.00 46.23  ? 209 ILE   R CB  1 
ATOM   2284 C CG1 . ILE   B 2 347 ? 123.955 127.840 137.493 1.00 51.48  ? 209 ILE   R CG1 1 
ATOM   2285 C CG2 . ILE   B 2 347 ? 125.006 125.870 138.616 1.00 48.25  ? 209 ILE   R CG2 1 
ATOM   2286 C CD1 . ILE   B 2 347 ? 122.685 127.073 137.240 1.00 52.82  ? 209 ILE   R CD1 1 
ATOM   2287 N N   . LEU   B 2 348 ? 128.155 126.136 137.611 1.00 49.51  ? 210 LEU   R N   1 
ATOM   2288 C CA  . LEU   B 2 348 ? 129.247 125.279 138.071 1.00 44.55  ? 210 LEU   R CA  1 
ATOM   2289 C C   . LEU   B 2 348 ? 130.436 126.081 138.589 1.00 46.86  ? 210 LEU   R C   1 
ATOM   2290 O O   . LEU   B 2 348 ? 130.859 125.842 139.736 1.00 56.71  ? 210 LEU   R O   1 
ATOM   2291 C CB  . LEU   B 2 348 ? 129.652 124.314 136.952 1.00 43.75  ? 210 LEU   R CB  1 
ATOM   2292 C CG  . LEU   B 2 348 ? 128.533 123.446 136.375 1.00 50.99  ? 210 LEU   R CG  1 
ATOM   2293 C CD1 . LEU   B 2 348 ? 129.090 122.429 135.393 1.00 52.46  ? 210 LEU   R CD1 1 
ATOM   2294 C CD2 . LEU   B 2 348 ? 127.764 122.754 137.484 1.00 49.46  ? 210 LEU   R CD2 1 
ATOM   2295 N N   . PRO   B 2 349 ? 131.006 127.037 137.844 1.00 41.93  ? 211 PRO   R N   1 
ATOM   2296 C CA  . PRO   B 2 349 ? 132.032 127.891 138.456 1.00 42.64  ? 211 PRO   R CA  1 
ATOM   2297 C C   . PRO   B 2 349 ? 131.491 128.691 139.615 1.00 52.77  ? 211 PRO   R C   1 
ATOM   2298 O O   . PRO   B 2 349 ? 132.205 128.904 140.602 1.00 60.99  ? 211 PRO   R O   1 
ATOM   2299 C CB  . PRO   B 2 349 ? 132.479 128.802 137.304 1.00 50.01  ? 211 PRO   R CB  1 
ATOM   2300 C CG  . PRO   B 2 349 ? 131.931 128.196 136.075 1.00 58.77  ? 211 PRO   R CG  1 
ATOM   2301 C CD  . PRO   B 2 349 ? 130.690 127.489 136.480 1.00 51.36  ? 211 PRO   R CD  1 
ATOM   2302 N N   . GLY   B 2 350 ? 130.236 129.129 139.528 1.00 49.18  ? 212 GLY   R N   1 
ATOM   2303 C CA  . GLY   B 2 350 ? 129.635 129.840 140.639 1.00 46.25  ? 212 GLY   R CA  1 
ATOM   2304 C C   . GLY   B 2 350 ? 129.543 128.987 141.886 1.00 44.63  ? 212 GLY   R C   1 
ATOM   2305 O O   . GLY   B 2 350 ? 129.826 129.456 142.985 1.00 46.52  ? 212 GLY   R O   1 
ATOM   2306 N N   . ILE   B 2 351 ? 129.156 127.721 141.732 1.00 39.70  ? 213 ILE   R N   1 
ATOM   2307 C CA  . ILE   B 2 351 ? 129.060 126.824 142.880 1.00 31.62  ? 213 ILE   R CA  1 
ATOM   2308 C C   . ILE   B 2 351 ? 130.437 126.558 143.473 1.00 42.44  ? 213 ILE   R C   1 
ATOM   2309 O O   . ILE   B 2 351 ? 130.609 126.550 144.701 1.00 55.83  ? 213 ILE   R O   1 
ATOM   2310 C CB  . ILE   B 2 351 ? 128.348 125.522 142.476 1.00 39.28  ? 213 ILE   R CB  1 
ATOM   2311 C CG1 . ILE   B 2 351 ? 126.839 125.746 142.415 1.00 45.54  ? 213 ILE   R CG1 1 
ATOM   2312 C CG2 . ILE   B 2 351 ? 128.683 124.400 143.436 1.00 46.47  ? 213 ILE   R CG2 1 
ATOM   2313 C CD1 . ILE   B 2 351 ? 126.071 124.560 141.888 1.00 47.44  ? 213 ILE   R CD1 1 
ATOM   2314 N N   . VAL   B 2 352 ? 131.440 126.340 142.620 1.00 50.71  ? 214 VAL   R N   1 
ATOM   2315 C CA  . VAL   B 2 352 ? 132.797 126.121 143.118 1.00 49.28  ? 214 VAL   R CA  1 
ATOM   2316 C C   . VAL   B 2 352 ? 133.278 127.338 143.902 1.00 47.58  ? 214 VAL   R C   1 
ATOM   2317 O O   . VAL   B 2 352 ? 133.852 127.213 144.991 1.00 55.66  ? 214 VAL   R O   1 
ATOM   2318 C CB  . VAL   B 2 352 ? 133.748 125.783 141.956 1.00 49.08  ? 214 VAL   R CB  1 
ATOM   2319 C CG1 . VAL   B 2 352 ? 135.179 125.722 142.445 1.00 45.57  ? 214 VAL   R CG1 1 
ATOM   2320 C CG2 . VAL   B 2 352 ? 133.352 124.468 141.311 1.00 46.37  ? 214 VAL   R CG2 1 
ATOM   2321 N N   . ILE   B 2 353 ? 133.040 128.536 143.363 1.00 43.96  ? 215 ILE   R N   1 
ATOM   2322 C CA  . ILE   B 2 353 ? 133.478 129.759 144.029 1.00 44.46  ? 215 ILE   R CA  1 
ATOM   2323 C C   . ILE   B 2 353 ? 132.713 129.976 145.331 1.00 58.81  ? 215 ILE   R C   1 
ATOM   2324 O O   . ILE   B 2 353 ? 133.295 130.385 146.341 1.00 62.42  ? 215 ILE   R O   1 
ATOM   2325 C CB  . ILE   B 2 353 ? 133.336 130.957 143.074 1.00 47.71  ? 215 ILE   R CB  1 
ATOM   2326 C CG1 . ILE   B 2 353 ? 134.284 130.803 141.887 1.00 48.57  ? 215 ILE   R CG1 1 
ATOM   2327 C CG2 . ILE   B 2 353 ? 133.632 132.253 143.794 1.00 54.76  ? 215 ILE   R CG2 1 
ATOM   2328 C CD1 . ILE   B 2 353 ? 133.954 131.716 140.731 1.00 51.15  ? 215 ILE   R CD1 1 
ATOM   2329 N N   . LEU   B 2 354 ? 131.400 129.715 145.333 1.00 56.39  ? 216 LEU   R N   1 
ATOM   2330 C CA  . LEU   B 2 354 ? 130.625 129.804 146.567 1.00 48.82  ? 216 LEU   R CA  1 
ATOM   2331 C C   . LEU   B 2 354 ? 131.210 128.904 147.642 1.00 53.96  ? 216 LEU   R C   1 
ATOM   2332 O O   . LEU   B 2 354 ? 131.437 129.343 148.771 1.00 68.28  ? 216 LEU   R O   1 
ATOM   2333 C CB  . LEU   B 2 354 ? 129.158 129.433 146.329 1.00 49.23  ? 216 LEU   R CB  1 
ATOM   2334 C CG  . LEU   B 2 354 ? 128.187 130.241 145.473 1.00 61.05  ? 216 LEU   R CG  1 
ATOM   2335 C CD1 . LEU   B 2 354 ? 126.870 129.485 145.359 1.00 62.31  ? 216 LEU   R CD1 1 
ATOM   2336 C CD2 . LEU   B 2 354 ? 127.950 131.584 146.100 1.00 54.19  ? 216 LEU   R CD2 1 
ATOM   2337 N N   . SER   B 2 355 ? 131.470 127.639 147.309 1.00 40.73  ? 217 SER   R N   1 
ATOM   2338 C CA  . SER   B 2 355 ? 131.996 126.720 148.312 1.00 46.11  ? 217 SER   R CA  1 
ATOM   2339 C C   . SER   B 2 355 ? 133.353 127.187 148.822 1.00 49.78  ? 217 SER   R C   1 
ATOM   2340 O O   . SER   B 2 355 ? 133.575 127.298 150.039 1.00 61.64  ? 217 SER   R O   1 
ATOM   2341 C CB  . SER   B 2 355 ? 132.096 125.315 147.726 1.00 54.72  ? 217 SER   R CB  1 
ATOM   2342 O OG  . SER   B 2 355 ? 130.829 124.871 147.288 1.00 64.60  ? 217 SER   R OG  1 
ATOM   2343 N N   . CYS   B 2 356 ? 134.268 127.490 147.898 1.00 49.01  ? 218 CYS   R N   1 
ATOM   2344 C CA  . CYS   B 2 356 ? 135.617 127.873 148.294 1.00 51.71  ? 218 CYS   R CA  1 
ATOM   2345 C C   . CYS   B 2 356 ? 135.598 129.116 149.173 1.00 54.72  ? 218 CYS   R C   1 
ATOM   2346 O O   . CYS   B 2 356 ? 136.233 129.150 150.230 1.00 62.85  ? 218 CYS   R O   1 
ATOM   2347 C CB  . CYS   B 2 356 ? 136.483 128.103 147.056 1.00 52.91  ? 218 CYS   R CB  1 
ATOM   2348 S SG  . CYS   B 2 356 ? 136.937 126.597 146.176 1.00 75.14  ? 218 CYS   R SG  1 
ATOM   2349 N N   . TYR   B 2 357 ? 134.848 130.142 148.771 1.00 52.60  ? 219 TYR   R N   1 
ATOM   2350 C CA  . TYR   B 2 357 ? 134.902 131.394 149.512 1.00 52.86  ? 219 TYR   R CA  1 
ATOM   2351 C C   . TYR   B 2 357 ? 134.056 131.360 150.774 1.00 52.32  ? 219 TYR   R C   1 
ATOM   2352 O O   . TYR   B 2 357 ? 134.381 132.060 151.734 1.00 59.08  ? 219 TYR   R O   1 
ATOM   2353 C CB  . TYR   B 2 357 ? 134.502 132.557 148.608 1.00 51.01  ? 219 TYR   R CB  1 
ATOM   2354 C CG  . TYR   B 2 357 ? 135.676 133.032 147.798 1.00 53.36  ? 219 TYR   R CG  1 
ATOM   2355 C CD1 . TYR   B 2 357 ? 136.649 133.839 148.363 1.00 57.04  ? 219 TYR   R CD1 1 
ATOM   2356 C CD2 . TYR   B 2 357 ? 135.840 132.632 146.485 1.00 51.60  ? 219 TYR   R CD2 1 
ATOM   2357 C CE1 . TYR   B 2 357 ? 137.737 134.255 147.634 1.00 57.03  ? 219 TYR   R CE1 1 
ATOM   2358 C CE2 . TYR   B 2 357 ? 136.922 133.043 145.750 1.00 53.78  ? 219 TYR   R CE2 1 
ATOM   2359 C CZ  . TYR   B 2 357 ? 137.867 133.855 146.327 1.00 58.40  ? 219 TYR   R CZ  1 
ATOM   2360 O OH  . TYR   B 2 357 ? 138.950 134.268 145.591 1.00 63.83  ? 219 TYR   R OH  1 
ATOM   2361 N N   . CYS   B 2 358 ? 133.003 130.545 150.822 1.00 55.26  ? 220 CYS   R N   1 
ATOM   2362 C CA  . CYS   B 2 358 ? 132.298 130.343 152.080 1.00 55.97  ? 220 CYS   R CA  1 
ATOM   2363 C C   . CYS   B 2 358 ? 133.220 129.714 153.114 1.00 55.10  ? 220 CYS   R C   1 
ATOM   2364 O O   . CYS   B 2 358 ? 133.309 130.189 154.252 1.00 66.36  ? 220 CYS   R O   1 
ATOM   2365 C CB  . CYS   B 2 358 ? 131.058 129.479 151.853 1.00 57.27  ? 220 CYS   R CB  1 
ATOM   2366 S SG  . CYS   B 2 358 ? 130.197 128.998 153.361 1.00 80.18  ? 220 CYS   R SG  1 
ATOM   2367 N N   . ILE   B 2 359 ? 133.950 128.664 152.722 1.00 47.88  ? 221 ILE   R N   1 
ATOM   2368 C CA  . ILE   B 2 359 ? 134.902 128.057 153.652 1.00 53.03  ? 221 ILE   R CA  1 
ATOM   2369 C C   . ILE   B 2 359 ? 136.000 129.051 154.021 1.00 53.42  ? 221 ILE   R C   1 
ATOM   2370 O O   . ILE   B 2 359 ? 136.387 129.168 155.193 1.00 58.44  ? 221 ILE   R O   1 
ATOM   2371 C CB  . ILE   B 2 359 ? 135.485 126.763 153.055 1.00 54.53  ? 221 ILE   R CB  1 
ATOM   2372 C CG1 . ILE   B 2 359 ? 134.368 125.767 152.750 1.00 51.81  ? 221 ILE   R CG1 1 
ATOM   2373 C CG2 . ILE   B 2 359 ? 136.480 126.140 154.010 1.00 52.71  ? 221 ILE   R CG2 1 
ATOM   2374 C CD1 . ILE   B 2 359 ? 133.607 125.319 153.968 1.00 52.98  ? 221 ILE   R CD1 1 
ATOM   2375 N N   . ILE   B 2 360 ? 136.506 129.792 153.034 1.00 47.90  ? 222 ILE   R N   1 
ATOM   2376 C CA  . ILE   B 2 360 ? 137.605 130.723 153.277 1.00 44.68  ? 222 ILE   R CA  1 
ATOM   2377 C C   . ILE   B 2 360 ? 137.185 131.800 154.267 1.00 52.98  ? 222 ILE   R C   1 
ATOM   2378 O O   . ILE   B 2 360 ? 137.919 132.122 155.204 1.00 61.46  ? 222 ILE   R O   1 
ATOM   2379 C CB  . ILE   B 2 360 ? 138.089 131.334 151.950 1.00 47.04  ? 222 ILE   R CB  1 
ATOM   2380 C CG1 . ILE   B 2 360 ? 139.071 130.397 151.255 1.00 50.48  ? 222 ILE   R CG1 1 
ATOM   2381 C CG2 . ILE   B 2 360 ? 138.740 132.682 152.178 1.00 55.80  ? 222 ILE   R CG2 1 
ATOM   2382 C CD1 . ILE   B 2 360 ? 139.391 130.813 149.845 1.00 56.25  ? 222 ILE   R CD1 1 
ATOM   2383 N N   . ILE   B 2 361 ? 135.996 132.374 154.076 1.00 51.03  ? 223 ILE   R N   1 
ATOM   2384 C CA  . ILE   B 2 361 ? 135.533 133.438 154.957 1.00 46.51  ? 223 ILE   R CA  1 
ATOM   2385 C C   . ILE   B 2 361 ? 135.184 132.893 156.334 1.00 54.86  ? 223 ILE   R C   1 
ATOM   2386 O O   . ILE   B 2 361 ? 135.410 133.566 157.346 1.00 63.62  ? 223 ILE   R O   1 
ATOM   2387 C CB  . ILE   B 2 361 ? 134.352 134.177 154.305 1.00 47.54  ? 223 ILE   R CB  1 
ATOM   2388 C CG1 . ILE   B 2 361 ? 134.847 134.933 153.075 1.00 54.55  ? 223 ILE   R CG1 1 
ATOM   2389 C CG2 . ILE   B 2 361 ? 133.700 135.135 155.284 1.00 52.64  ? 223 ILE   R CG2 1 
ATOM   2390 C CD1 . ILE   B 2 361 ? 133.752 135.404 152.181 1.00 59.30  ? 223 ILE   R CD1 1 
ATOM   2391 N N   . SER   B 2 362 ? 134.642 131.675 156.410 1.00 54.82  ? 224 SER   R N   1 
ATOM   2392 C CA  . SER   B 2 362 ? 134.429 131.067 157.718 1.00 44.13  ? 224 SER   R CA  1 
ATOM   2393 C C   . SER   B 2 362 ? 135.744 130.859 158.455 1.00 45.47  ? 224 SER   R C   1 
ATOM   2394 O O   . SER   B 2 362 ? 135.772 130.895 159.689 1.00 61.61  ? 224 SER   R O   1 
ATOM   2395 C CB  . SER   B 2 362 ? 133.686 129.742 157.570 1.00 50.89  ? 224 SER   R CB  1 
ATOM   2396 O OG  . SER   B 2 362 ? 132.347 129.954 157.160 1.00 57.66  ? 224 SER   R OG  1 
ATOM   2397 N N   . ARG   B 2 363 ? 136.838 130.637 157.725 1.00 49.38  ? 225 ARG   R N   1 
ATOM   2398 C CA  . ARG   B 2 363 ? 138.144 130.504 158.362 1.00 51.47  ? 225 ARG   R CA  1 
ATOM   2399 C C   . ARG   B 2 363 ? 138.815 131.837 158.665 1.00 46.44  ? 225 ARG   R C   1 
ATOM   2400 O O   . ARG   B 2 363 ? 139.601 131.913 159.613 1.00 57.40  ? 225 ARG   R O   1 
ATOM   2401 C CB  . ARG   B 2 363 ? 139.086 129.664 157.495 1.00 55.53  ? 225 ARG   R CB  1 
ATOM   2402 C CG  . ARG   B 2 363 ? 138.616 128.241 157.286 1.00 56.18  ? 225 ARG   R CG  1 
ATOM   2403 C CD  . ARG   B 2 363 ? 138.541 127.488 158.600 1.00 54.00  ? 225 ARG   R CD  1 
ATOM   2404 N NE  . ARG   B 2 363 ? 137.956 126.165 158.426 1.00 57.01  ? 225 ARG   R NE  1 
ATOM   2405 C CZ  . ARG   B 2 363 ? 138.653 125.064 158.184 1.00 65.97  ? 225 ARG   R CZ  1 
ATOM   2406 N NH1 . ARG   B 2 363 ? 139.973 125.087 158.099 1.00 64.01  ? 225 ARG   R NH1 1 
ATOM   2407 N NH2 . ARG   B 2 363 ? 138.010 123.911 158.024 1.00 66.36  ? 225 ARG   R NH2 1 
ATOM   2408 N N   . LEU   B 2 364 ? 138.534 132.883 157.890 1.00 47.08  ? 226 LEU   R N   1 
ATOM   2409 C CA  . LEU   B 2 364 ? 139.208 134.161 158.091 1.00 54.31  ? 226 LEU   R CA  1 
ATOM   2410 C C   . LEU   B 2 364 ? 138.693 134.896 159.319 1.00 56.73  ? 226 LEU   R C   1 
ATOM   2411 O O   . LEU   B 2 364 ? 139.455 135.621 159.966 1.00 60.51  ? 226 LEU   R O   1 
ATOM   2412 C CB  . LEU   B 2 364 ? 139.048 135.050 156.857 1.00 55.92  ? 226 LEU   R CB  1 
ATOM   2413 C CG  . LEU   B 2 364 ? 139.766 134.637 155.571 1.00 50.76  ? 226 LEU   R CG  1 
ATOM   2414 C CD1 . LEU   B 2 364 ? 139.360 135.545 154.430 1.00 48.38  ? 226 LEU   R CD1 1 
ATOM   2415 C CD2 . LEU   B 2 364 ? 141.269 134.645 155.753 1.00 54.63  ? 226 LEU   R CD2 1 
ATOM   2416 N N   . LYS   B 2 365 ? 137.414 134.735 159.648 1.00 62.12  ? 227 LYS   R N   1 
ATOM   2417 C CA  . LYS   B 2 365 ? 136.809 135.413 160.784 1.00 60.19  ? 227 LYS   R CA  1 
ATOM   2418 C C   . LYS   B 2 365 ? 136.763 134.553 162.038 1.00 61.23  ? 227 LYS   R C   1 
ATOM   2419 O O   . LYS   B 2 365 ? 136.211 134.993 163.050 1.00 69.60  ? 227 LYS   R O   1 
ATOM   2420 C CB  . LYS   B 2 365 ? 135.396 135.880 160.426 1.00 56.97  ? 227 LYS   R CB  1 
ATOM   2421 C CG  . LYS   B 2 365 ? 134.367 134.771 160.386 1.00 61.41  ? 227 LYS   R CG  1 
ATOM   2422 C CD  . LYS   B 2 365 ? 132.965 135.329 160.223 1.00 61.35  ? 227 LYS   R CD  1 
ATOM   2423 C CE  . LYS   B 2 365 ? 132.826 136.094 158.921 1.00 60.99  ? 227 LYS   R CE  1 
ATOM   2424 N NZ  . LYS   B 2 365 ? 131.423 136.527 158.677 1.00 65.77  ? 227 LYS   R NZ  1 
ATOM   2425 N N   . SER   B 2 366 ? 137.320 133.347 162.003 1.00 54.95  ? 228 SER   R N   1 
ATOM   2426 C CA  . SER   B 2 366 ? 137.337 132.475 163.169 1.00 57.07  ? 228 SER   R CA  1 
ATOM   2427 C C   . SER   B 2 366 ? 138.727 132.017 163.573 1.00 58.41  ? 228 SER   R C   1 
ATOM   2428 O O   . SER   B 2 366 ? 138.961 131.792 164.761 1.00 63.11  ? 228 SER   R O   1 
ATOM   2429 C CB  . SER   B 2 366 ? 136.463 131.236 162.927 1.00 61.58  ? 228 SER   R CB  1 
ATOM   2430 O OG  . SER   B 2 366 ? 137.066 130.361 161.991 1.00 67.64  ? 228 SER   R OG  1 
ATOM   2431 N N   . VAL   B 2 367 ? 139.652 131.878 162.631 1.00 57.20  ? 229 VAL   R N   1 
ATOM   2432 C CA  . VAL   B 2 367 ? 141.012 131.452 162.937 1.00 58.31  ? 229 VAL   R CA  1 
ATOM   2433 C C   . VAL   B 2 367 ? 141.800 132.672 163.391 1.00 58.32  ? 229 VAL   R C   1 
ATOM   2434 O O   . VAL   B 2 367 ? 141.865 133.681 162.681 1.00 59.55  ? 229 VAL   R O   1 
ATOM   2435 C CB  . VAL   B 2 367 ? 141.676 130.784 161.725 1.00 56.77  ? 229 VAL   R CB  1 
ATOM   2436 C CG1 . VAL   B 2 367 ? 143.168 130.631 161.957 1.00 60.45  ? 229 VAL   R CG1 1 
ATOM   2437 C CG2 . VAL   B 2 367 ? 141.036 129.437 161.452 1.00 61.50  ? 229 VAL   R CG2 1 
ATOM   2438 N N   . ARG   B 2 368 ? 142.398 132.578 164.579 1.00 67.75  ? 230 ARG   R N   1 
ATOM   2439 C CA  . ARG   B 2 368 ? 143.138 133.708 165.128 1.00 70.36  ? 230 ARG   R CA  1 
ATOM   2440 C C   . ARG   B 2 368 ? 144.322 134.076 164.247 1.00 68.24  ? 230 ARG   R C   1 
ATOM   2441 O O   . ARG   B 2 368 ? 144.604 135.261 164.038 1.00 74.16  ? 230 ARG   R O   1 
ATOM   2442 C CB  . ARG   B 2 368 ? 143.610 133.387 166.545 1.00 64.79  ? 230 ARG   R CB  1 
ATOM   2443 C CG  . ARG   B 2 368 ? 144.294 134.543 167.243 1.00 66.78  ? 230 ARG   R CG  1 
ATOM   2444 C CD  . ARG   B 2 368 ? 144.976 134.083 168.516 1.00 69.08  ? 230 ARG   R CD  1 
ATOM   2445 N NE  . ARG   B 2 368 ? 146.235 133.405 168.240 1.00 72.01  ? 230 ARG   R NE  1 
ATOM   2446 C CZ  . ARG   B 2 368 ? 147.426 133.983 168.304 1.00 72.28  ? 230 ARG   R CZ  1 
ATOM   2447 N NH1 . ARG   B 2 368 ? 147.559 135.253 168.648 1.00 69.79  ? 230 ARG   R NH1 1 
ATOM   2448 N NH2 . ARG   B 2 368 ? 148.511 133.269 168.019 1.00 71.82  ? 230 ARG   R NH2 1 
ATOM   2449 N N   . LEU   B 2 369 ? 145.024 133.077 163.719 1.00 65.20  ? 231 LEU   R N   1 
ATOM   2450 C CA  . LEU   B 2 369 ? 146.256 133.329 162.980 1.00 65.83  ? 231 LEU   R CA  1 
ATOM   2451 C C   . LEU   B 2 369 ? 146.454 132.198 161.982 1.00 70.11  ? 231 LEU   R C   1 
ATOM   2452 O O   . LEU   B 2 369 ? 146.729 131.064 162.382 1.00 72.96  ? 231 LEU   R O   1 
ATOM   2453 C CB  . LEU   B 2 369 ? 147.438 133.437 163.935 1.00 66.65  ? 231 LEU   R CB  1 
ATOM   2454 C CG  . LEU   B 2 369 ? 148.784 133.875 163.369 1.00 71.13  ? 231 LEU   R CG  1 
ATOM   2455 C CD1 . LEU   B 2 369 ? 148.691 135.295 162.844 1.00 72.39  ? 231 LEU   R CD1 1 
ATOM   2456 C CD2 . LEU   B 2 369 ? 149.855 133.765 164.438 1.00 72.51  ? 231 LEU   R CD2 1 
ATOM   2457 N N   . LEU   B 2 370 ? 146.313 132.505 160.695 1.00 70.18  ? 232 LEU   R N   1 
ATOM   2458 C CA  . LEU   B 2 370 ? 146.559 131.514 159.658 1.00 68.58  ? 232 LEU   R CA  1 
ATOM   2459 C C   . LEU   B 2 370 ? 148.034 131.135 159.630 1.00 72.43  ? 232 LEU   R C   1 
ATOM   2460 O O   . LEU   B 2 370 ? 148.910 131.934 159.973 1.00 74.41  ? 232 LEU   R O   1 
ATOM   2461 C CB  . LEU   B 2 370 ? 146.130 132.045 158.292 1.00 66.49  ? 232 LEU   R CB  1 
ATOM   2462 C CG  . LEU   B 2 370 ? 144.630 132.213 158.056 1.00 65.44  ? 232 LEU   R CG  1 
ATOM   2463 C CD1 . LEU   B 2 370 ? 144.381 132.888 156.721 1.00 64.82  ? 232 LEU   R CD1 1 
ATOM   2464 C CD2 . LEU   B 2 370 ? 143.925 130.872 158.118 1.00 68.54  ? 232 LEU   R CD2 1 
ATOM   2465 N N   . SER   B 2 371 ? 148.302 129.900 159.211 1.00 73.20  ? 233 SER   R N   1 
ATOM   2466 C CA  . SER   B 2 371 ? 149.652 129.321 159.226 1.00 71.96  ? 233 SER   R CA  1 
ATOM   2467 C C   . SER   B 2 371 ? 150.145 129.398 160.669 1.00 72.01  ? 233 SER   R C   1 
ATOM   2468 O O   . SER   B 2 371 ? 149.445 128.916 161.574 1.00 73.94  ? 233 SER   R O   1 
ATOM   2469 C CB  . SER   B 2 371 ? 150.527 130.014 158.188 1.00 71.06  ? 233 SER   R CB  1 
ATOM   2470 O OG  . SER   B 2 371 ? 150.243 129.543 156.884 1.00 77.74  ? 233 SER   R OG  1 
ATOM   2471 N N   . GLY   B 2 372 ? 151.306 129.985 160.939 1.00 75.48  ? 234 GLY   R N   1 
ATOM   2472 C CA  . GLY   B 2 372 ? 151.771 130.109 162.305 1.00 78.97  ? 234 GLY   R CA  1 
ATOM   2473 C C   . GLY   B 2 372 ? 152.484 131.414 162.589 1.00 80.30  ? 234 GLY   R C   1 
ATOM   2474 O O   . GLY   B 2 372 ? 153.030 131.604 163.679 1.00 82.97  ? 234 GLY   R O   1 
ATOM   2475 N N   . SER   B 2 373 ? 152.481 132.326 161.620 1.00 86.13  ? 235 SER   R N   1 
ATOM   2476 C CA  . SER   B 2 373 ? 153.171 133.598 161.763 1.00 86.76  ? 235 SER   R CA  1 
ATOM   2477 C C   . SER   B 2 373 ? 152.275 134.721 161.264 1.00 90.76  ? 235 SER   R C   1 
ATOM   2478 O O   . SER   B 2 373 ? 151.370 134.512 160.454 1.00 91.67  ? 235 SER   R O   1 
ATOM   2479 C CB  . SER   B 2 373 ? 154.505 133.605 161.005 1.00 87.81  ? 235 SER   R CB  1 
ATOM   2480 O OG  . SER   B 2 373 ? 154.302 133.474 159.611 1.00 84.73  ? 235 SER   R OG  1 
ATOM   2481 N N   . ARG   B 2 374 ? 152.542 135.925 161.772 1.00 91.86  ? 236 ARG   R N   1 
ATOM   2482 C CA  . ARG   B 2 374 ? 151.749 137.091 161.396 1.00 93.04  ? 236 ARG   R CA  1 
ATOM   2483 C C   . ARG   B 2 374 ? 151.953 137.459 159.930 1.00 95.48  ? 236 ARG   R C   1 
ATOM   2484 O O   . ARG   B 2 374 ? 150.993 137.820 159.234 1.00 100.15 ? 236 ARG   R O   1 
ATOM   2485 C CB  . ARG   B 2 374 ? 152.109 138.267 162.302 1.00 91.56  ? 236 ARG   R CB  1 
ATOM   2486 C CG  . ARG   B 2 374 ? 151.006 139.292 162.470 1.00 93.43  ? 236 ARG   R CG  1 
ATOM   2487 C CD  . ARG   B 2 374 ? 151.268 140.170 163.681 1.00 93.33  ? 236 ARG   R CD  1 
ATOM   2488 N NE  . ARG   B 2 374 ? 151.337 139.386 164.908 1.00 95.95  ? 236 ARG   R NE  1 
ATOM   2489 C CZ  . ARG   B 2 374 ? 151.353 139.905 166.128 1.00 97.41  ? 236 ARG   R CZ  1 
ATOM   2490 N NH1 . ARG   B 2 374 ? 151.304 141.212 166.325 1.00 94.64  ? 236 ARG   R NH1 1 
ATOM   2491 N NH2 . ARG   B 2 374 ? 151.418 139.091 167.178 1.00 95.56  ? 236 ARG   R NH2 1 
ATOM   2492 N N   . GLU   B 2 375 ? 153.196 137.382 159.447 1.00 91.27  ? 237 GLU   R N   1 
ATOM   2493 C CA  . GLU   B 2 375 ? 153.487 137.803 158.080 1.00 89.19  ? 237 GLU   R CA  1 
ATOM   2494 C C   . GLU   B 2 375 ? 152.773 136.924 157.061 1.00 91.19  ? 237 GLU   R C   1 
ATOM   2495 O O   . GLU   B 2 375 ? 152.229 137.428 156.071 1.00 94.02  ? 237 GLU   R O   1 
ATOM   2496 C CB  . GLU   B 2 375 ? 154.999 137.808 157.843 1.00 89.68  ? 237 GLU   R CB  1 
ATOM   2497 C CG  . GLU   B 2 375 ? 155.678 136.451 157.953 1.00 95.47  ? 237 GLU   R CG  1 
ATOM   2498 C CD  . GLU   B 2 375 ? 156.373 136.251 159.286 1.00 98.70  ? 237 GLU   R CD  1 
ATOM   2499 O OE1 . GLU   B 2 375 ? 156.278 137.151 160.148 1.00 97.70  ? 237 GLU   R OE1 1 
ATOM   2500 O OE2 . GLU   B 2 375 ? 157.015 135.196 159.473 1.00 95.20  ? 237 GLU   R OE2 1 
ATOM   2501 N N   . LYS   B 2 376 ? 152.750 135.610 157.288 1.00 81.83  ? 238 LYS   R N   1 
ATOM   2502 C CA  . LYS   B 2 376 ? 152.028 134.726 156.382 1.00 84.93  ? 238 LYS   R CA  1 
ATOM   2503 C C   . LYS   B 2 376 ? 150.533 135.011 156.416 1.00 88.12  ? 238 LYS   R C   1 
ATOM   2504 O O   . LYS   B 2 376 ? 149.867 134.990 155.374 1.00 92.80  ? 238 LYS   R O   1 
ATOM   2505 C CB  . LYS   B 2 376 ? 152.314 133.267 156.732 1.00 87.76  ? 238 LYS   R CB  1 
ATOM   2506 C CG  . LYS   B 2 376 ? 153.754 132.851 156.478 1.00 89.21  ? 238 LYS   R CG  1 
ATOM   2507 C CD  . LYS   B 2 376 ? 153.990 131.398 156.854 1.00 89.60  ? 238 LYS   R CD  1 
ATOM   2508 C CE  . LYS   B 2 376 ? 155.456 131.026 156.716 1.00 89.32  ? 238 LYS   R CE  1 
ATOM   2509 N NZ  . LYS   B 2 376 ? 155.728 129.647 157.204 1.00 88.41  ? 238 LYS   R NZ  1 
ATOM   2510 N N   . ASP   B 2 377 ? 149.993 135.294 157.602 1.00 73.45  ? 239 ASP   R N   1 
ATOM   2511 C CA  . ASP   B 2 377 ? 148.581 135.644 157.719 1.00 71.31  ? 239 ASP   R CA  1 
ATOM   2512 C C   . ASP   B 2 377 ? 148.244 136.867 156.873 1.00 78.91  ? 239 ASP   R C   1 
ATOM   2513 O O   . ASP   B 2 377 ? 147.317 136.835 156.050 1.00 78.93  ? 239 ASP   R O   1 
ATOM   2514 C CB  . ASP   B 2 377 ? 148.238 135.896 159.186 1.00 68.37  ? 239 ASP   R CB  1 
ATOM   2515 C CG  . ASP   B 2 377 ? 146.749 135.979 159.434 1.00 76.72  ? 239 ASP   R CG  1 
ATOM   2516 O OD1 . ASP   B 2 377 ? 145.968 135.685 158.506 1.00 84.84  ? 239 ASP   R OD1 1 
ATOM   2517 O OD2 . ASP   B 2 377 ? 146.358 136.349 160.559 1.00 79.45  ? 239 ASP   R OD2 1 
ATOM   2518 N N   . ARG   B 2 378 ? 148.998 137.956 157.053 1.00 84.44  ? 240 ARG   R N   1 
ATOM   2519 C CA  . ARG   B 2 378 ? 148.683 139.174 156.315 1.00 77.93  ? 240 ARG   R CA  1 
ATOM   2520 C C   . ARG   B 2 378 ? 148.928 139.007 154.821 1.00 78.43  ? 240 ARG   R C   1 
ATOM   2521 O O   . ARG   B 2 378 ? 148.176 139.562 154.012 1.00 85.40  ? 240 ARG   R O   1 
ATOM   2522 C CB  . ARG   B 2 378 ? 149.467 140.363 156.872 1.00 75.92  ? 240 ARG   R CB  1 
ATOM   2523 C CG  . ARG   B 2 378 ? 150.971 140.229 156.845 1.00 80.08  ? 240 ARG   R CG  1 
ATOM   2524 C CD  . ARG   B 2 378 ? 151.621 141.474 157.425 1.00 82.89  ? 240 ARG   R CD  1 
ATOM   2525 N NE  . ARG   B 2 378 ? 153.054 141.309 157.632 1.00 88.54  ? 240 ARG   R NE  1 
ATOM   2526 C CZ  . ARG   B 2 378 ? 153.977 141.542 156.710 1.00 88.93  ? 240 ARG   R CZ  1 
ATOM   2527 N NH1 . ARG   B 2 378 ? 153.653 141.950 155.494 1.00 84.89  ? 240 ARG   R NH1 1 
ATOM   2528 N NH2 . ARG   B 2 378 ? 155.259 141.362 157.016 1.00 88.70  ? 240 ARG   R NH2 1 
ATOM   2529 N N   . ASN   B 2 379 ? 149.950 138.237 154.432 1.00 73.00  ? 241 ASN   R N   1 
ATOM   2530 C CA  . ASN   B 2 379 ? 150.156 137.961 153.014 1.00 69.92  ? 241 ASN   R CA  1 
ATOM   2531 C C   . ASN   B 2 379 ? 148.968 137.215 152.422 1.00 72.08  ? 241 ASN   R C   1 
ATOM   2532 O O   . ASN   B 2 379 ? 148.514 137.535 151.316 1.00 82.69  ? 241 ASN   R O   1 
ATOM   2533 C CB  . ASN   B 2 379 ? 151.441 137.160 152.813 1.00 71.02  ? 241 ASN   R CB  1 
ATOM   2534 C CG  . ASN   B 2 379 ? 152.686 137.997 153.014 1.00 80.56  ? 241 ASN   R CG  1 
ATOM   2535 O OD1 . ASN   B 2 379 ? 152.753 139.146 152.579 1.00 84.83  ? 241 ASN   R OD1 1 
ATOM   2536 N ND2 . ASN   B 2 379 ? 153.685 137.423 153.673 1.00 80.89  ? 241 ASN   R ND2 1 
ATOM   2537 N N   . LEU   B 2 380 ? 148.447 136.221 153.145 1.00 63.25  ? 242 LEU   R N   1 
ATOM   2538 C CA  . LEU   B 2 380 ? 147.293 135.480 152.649 1.00 60.60  ? 242 LEU   R CA  1 
ATOM   2539 C C   . LEU   B 2 380 ? 146.080 136.386 152.490 1.00 66.40  ? 242 LEU   R C   1 
ATOM   2540 O O   . LEU   B 2 380 ? 145.372 136.311 151.478 1.00 62.51  ? 242 LEU   R O   1 
ATOM   2541 C CB  . LEU   B 2 380 ? 146.975 134.313 153.583 1.00 67.83  ? 242 LEU   R CB  1 
ATOM   2542 C CG  . LEU   B 2 380 ? 147.970 133.152 153.599 1.00 70.90  ? 242 LEU   R CG  1 
ATOM   2543 C CD1 . LEU   B 2 380 ? 147.503 132.055 154.540 1.00 67.76  ? 242 LEU   R CD1 1 
ATOM   2544 C CD2 . LEU   B 2 380 ? 148.181 132.606 152.198 1.00 70.19  ? 242 LEU   R CD2 1 
ATOM   2545 N N   . ARG   B 2 381 ? 145.827 137.257 153.471 1.00 63.93  ? 243 ARG   R N   1 
ATOM   2546 C CA  . ARG   B 2 381 ? 144.686 138.167 153.360 1.00 60.16  ? 243 ARG   R CA  1 
ATOM   2547 C C   . ARG   B 2 381 ? 144.845 139.111 152.170 1.00 64.66  ? 243 ARG   R C   1 
ATOM   2548 O O   . ARG   B 2 381 ? 143.896 139.336 151.398 1.00 68.85  ? 243 ARG   R O   1 
ATOM   2549 C CB  . ARG   B 2 381 ? 144.518 138.969 154.651 1.00 60.82  ? 243 ARG   R CB  1 
ATOM   2550 C CG  . ARG   B 2 381 ? 144.613 138.160 155.925 1.00 61.06  ? 243 ARG   R CG  1 
ATOM   2551 C CD  . ARG   B 2 381 ? 143.278 137.588 156.344 1.00 61.95  ? 243 ARG   R CD  1 
ATOM   2552 N NE  . ARG   B 2 381 ? 143.419 136.689 157.483 1.00 63.79  ? 243 ARG   R NE  1 
ATOM   2553 C CZ  . ARG   B 2 381 ? 142.922 136.921 158.689 1.00 58.47  ? 243 ARG   R CZ  1 
ATOM   2554 N NH1 . ARG   B 2 381 ? 142.239 138.021 158.955 1.00 60.71  ? 243 ARG   R NH1 1 
ATOM   2555 N NH2 . ARG   B 2 381 ? 143.114 136.026 159.653 1.00 56.47  ? 243 ARG   R NH2 1 
ATOM   2556 N N   . ARG   B 2 382 ? 146.046 139.678 152.013 1.00 68.00  ? 244 ARG   R N   1 
ATOM   2557 C CA  . ARG   B 2 382 ? 146.292 140.636 150.941 1.00 63.05  ? 244 ARG   R CA  1 
ATOM   2558 C C   . ARG   B 2 382 ? 146.155 139.985 149.574 1.00 65.09  ? 244 ARG   R C   1 
ATOM   2559 O O   . ARG   B 2 382 ? 145.679 140.616 148.626 1.00 74.06  ? 244 ARG   R O   1 
ATOM   2560 C CB  . ARG   B 2 382 ? 147.681 141.252 151.096 1.00 61.73  ? 244 ARG   R CB  1 
ATOM   2561 C CG  . ARG   B 2 382 ? 147.717 142.516 151.933 1.00 68.99  ? 244 ARG   R CG  1 
ATOM   2562 C CD  . ARG   B 2 382 ? 149.138 142.847 152.352 1.00 73.06  ? 244 ARG   R CD  1 
ATOM   2563 N NE  . ARG   B 2 382 ? 150.072 142.733 151.239 1.00 77.26  ? 244 ARG   R NE  1 
ATOM   2564 C CZ  . ARG   B 2 382 ? 151.101 141.897 151.206 1.00 75.22  ? 244 ARG   R CZ  1 
ATOM   2565 N NH1 . ARG   B 2 382 ? 151.364 141.085 152.216 1.00 71.95  ? 244 ARG   R NH1 1 
ATOM   2566 N NH2 . ARG   B 2 382 ? 151.885 141.875 150.131 1.00 71.05  ? 244 ARG   R NH2 1 
ATOM   2567 N N   . ILE   B 2 383 ? 146.596 138.733 149.443 1.00 55.40  ? 245 ILE   R N   1 
ATOM   2568 C CA  . ILE   B 2 383 ? 146.441 138.039 148.170 1.00 55.07  ? 245 ILE   R CA  1 
ATOM   2569 C C   . ILE   B 2 383 ? 144.985 137.656 147.932 1.00 57.57  ? 245 ILE   R C   1 
ATOM   2570 O O   . ILE   B 2 383 ? 144.515 137.659 146.788 1.00 60.79  ? 245 ILE   R O   1 
ATOM   2571 C CB  . ILE   B 2 383 ? 147.375 136.817 148.120 1.00 58.33  ? 245 ILE   R CB  1 
ATOM   2572 C CG1 . ILE   B 2 383 ? 148.834 137.270 148.110 1.00 57.15  ? 245 ILE   R CG1 1 
ATOM   2573 C CG2 . ILE   B 2 383 ? 147.094 135.967 146.897 1.00 56.02  ? 245 ILE   R CG2 1 
ATOM   2574 C CD1 . ILE   B 2 383 ? 149.822 136.133 148.158 1.00 56.11  ? 245 ILE   R CD1 1 
ATOM   2575 N N   . THR   B 2 384 ? 144.241 137.336 148.993 1.00 54.76  ? 246 THR   R N   1 
ATOM   2576 C CA  . THR   B 2 384 ? 142.887 136.823 148.810 1.00 54.55  ? 246 THR   R CA  1 
ATOM   2577 C C   . THR   B 2 384 ? 141.905 137.923 148.417 1.00 55.66  ? 246 THR   R C   1 
ATOM   2578 O O   . THR   B 2 384 ? 141.015 137.691 147.592 1.00 54.87  ? 246 THR   R O   1 
ATOM   2579 C CB  . THR   B 2 384 ? 142.419 136.120 150.083 1.00 60.42  ? 246 THR   R CB  1 
ATOM   2580 O OG1 . THR   B 2 384 ? 143.394 135.149 150.479 1.00 56.89  ? 246 THR   R OG1 1 
ATOM   2581 C CG2 . THR   B 2 384 ? 141.094 135.415 149.845 1.00 52.82  ? 246 THR   R CG2 1 
ATOM   2582 N N   . ARG   B 2 385 ? 142.039 139.122 148.997 1.00 58.93  ? 247 ARG   R N   1 
ATOM   2583 C CA  . ARG   B 2 385 ? 141.010 140.149 148.799 1.00 59.48  ? 247 ARG   R CA  1 
ATOM   2584 C C   . ARG   B 2 385 ? 140.780 140.547 147.339 1.00 62.75  ? 247 ARG   R C   1 
ATOM   2585 O O   . ARG   B 2 385 ? 139.608 140.606 146.913 1.00 65.28  ? 247 ARG   R O   1 
ATOM   2586 C CB  . ARG   B 2 385 ? 141.344 141.379 149.647 1.00 51.67  ? 247 ARG   R CB  1 
ATOM   2587 C CG  . ARG   B 2 385 ? 140.258 142.439 149.625 1.00 54.40  ? 247 ARG   R CG  1 
ATOM   2588 C CD  . ARG   B 2 385 ? 140.550 143.555 150.606 1.00 60.41  ? 247 ARG   R CD  1 
ATOM   2589 N NE  . ARG   B 2 385 ? 141.442 144.559 150.041 1.00 65.27  ? 247 ARG   R NE  1 
ATOM   2590 C CZ  . ARG   B 2 385 ? 141.043 145.742 149.592 1.00 67.03  ? 247 ARG   R CZ  1 
ATOM   2591 N NH1 . ARG   B 2 385 ? 139.771 146.103 149.633 1.00 61.65  ? 247 ARG   R NH1 1 
ATOM   2592 N NH2 . ARG   B 2 385 ? 141.943 146.582 149.090 1.00 66.49  ? 247 ARG   R NH2 1 
ATOM   2593 N N   . PRO   B 2 386 ? 141.808 140.851 146.534 1.00 53.46  ? 248 PRO   R N   1 
ATOM   2594 C CA  . PRO   B 2 386 ? 141.541 141.261 145.147 1.00 43.86  ? 248 PRO   R CA  1 
ATOM   2595 C C   . PRO   B 2 386 ? 140.790 140.224 144.345 1.00 47.58  ? 248 PRO   R C   1 
ATOM   2596 O O   . PRO   B 2 386 ? 140.014 140.592 143.458 1.00 57.53  ? 248 PRO   R O   1 
ATOM   2597 C CB  . PRO   B 2 386 ? 142.944 141.498 144.577 1.00 51.70  ? 248 PRO   R CB  1 
ATOM   2598 C CG  . PRO   B 2 386 ? 143.776 141.799 145.754 1.00 50.40  ? 248 PRO   R CG  1 
ATOM   2599 C CD  . PRO   B 2 386 ? 143.247 140.919 146.835 1.00 55.56  ? 248 PRO   R CD  1 
ATOM   2600 N N   . THR   B 2 387 ? 141.001 138.937 144.618 1.00 55.18  ? 249 THR   R N   1 
ATOM   2601 C CA  . THR   B 2 387 ? 140.242 137.907 143.919 1.00 58.19  ? 249 THR   R CA  1 
ATOM   2602 C C   . THR   B 2 387 ? 138.760 138.005 144.251 1.00 54.97  ? 249 THR   R C   1 
ATOM   2603 O O   . THR   B 2 387 ? 137.906 137.811 143.378 1.00 55.50  ? 249 THR   R O   1 
ATOM   2604 C CB  . THR   B 2 387 ? 140.786 136.524 144.268 1.00 52.41  ? 249 THR   R CB  1 
ATOM   2605 O OG1 . THR   B 2 387 ? 140.282 136.120 145.545 1.00 55.58  ? 249 THR   R OG1 1 
ATOM   2606 C CG2 . THR   B 2 387 ? 142.302 136.551 144.320 1.00 53.22  ? 249 THR   R CG2 1 
ATOM   2607 N N   . VAL   B 2 388 ? 138.434 138.312 145.509 1.00 49.77  ? 250 VAL   R N   1 
ATOM   2608 C CA  . VAL   B 2 388 ? 137.038 138.501 145.893 1.00 48.02  ? 250 VAL   R CA  1 
ATOM   2609 C C   . VAL   B 2 388 ? 136.436 139.670 145.130 1.00 52.35  ? 250 VAL   R C   1 
ATOM   2610 O O   . VAL   B 2 388 ? 135.325 139.579 144.588 1.00 57.40  ? 250 VAL   R O   1 
ATOM   2611 C CB  . VAL   B 2 388 ? 136.921 138.708 147.413 1.00 43.21  ? 250 VAL   R CB  1 
ATOM   2612 C CG1 . VAL   B 2 388 ? 135.469 138.641 147.843 1.00 46.46  ? 250 VAL   R CG1 1 
ATOM   2613 C CG2 . VAL   B 2 388 ? 137.749 137.681 148.150 1.00 46.76  ? 250 VAL   R CG2 1 
ATOM   2614 N N   . ILE   B 2 389 ? 137.164 140.790 145.071 1.00 54.72  ? 251 ILE   R N   1 
ATOM   2615 C CA  . ILE   B 2 389 ? 136.640 141.952 144.352 1.00 50.59  ? 251 ILE   R CA  1 
ATOM   2616 C C   . ILE   B 2 389 ? 136.453 141.628 142.872 1.00 53.80  ? 251 ILE   R C   1 
ATOM   2617 O O   . ILE   B 2 389 ? 135.441 141.998 142.263 1.00 51.07  ? 251 ILE   R O   1 
ATOM   2618 C CB  . ILE   B 2 389 ? 137.553 143.175 144.553 1.00 49.76  ? 251 ILE   R CB  1 
ATOM   2619 C CG1 . ILE   B 2 389 ? 137.569 143.593 146.021 1.00 53.18  ? 251 ILE   R CG1 1 
ATOM   2620 C CG2 . ILE   B 2 389 ? 137.078 144.333 143.697 1.00 54.15  ? 251 ILE   R CG2 1 
ATOM   2621 C CD1 . ILE   B 2 389 ? 138.591 144.657 146.335 1.00 57.99  ? 251 ILE   R CD1 1 
ATOM   2622 N N   . LEU   B 2 390 ? 137.424 140.934 142.274 1.00 55.30  ? 252 LEU   R N   1 
ATOM   2623 C CA  . LEU   B 2 390 ? 137.346 140.587 140.858 1.00 48.29  ? 252 LEU   R CA  1 
ATOM   2624 C C   . LEU   B 2 390 ? 136.154 139.686 140.571 1.00 50.04  ? 252 LEU   R C   1 
ATOM   2625 O O   . LEU   B 2 390 ? 135.429 139.897 139.592 1.00 60.12  ? 252 LEU   R O   1 
ATOM   2626 C CB  . LEU   B 2 390 ? 138.645 139.910 140.420 1.00 53.72  ? 252 LEU   R CB  1 
ATOM   2627 C CG  . LEU   B 2 390 ? 138.713 139.257 139.038 1.00 56.07  ? 252 LEU   R CG  1 
ATOM   2628 C CD1 . LEU   B 2 390 ? 138.361 140.246 137.945 1.00 48.75  ? 252 LEU   R CD1 1 
ATOM   2629 C CD2 . LEU   B 2 390 ? 140.095 138.678 138.802 1.00 55.83  ? 252 LEU   R CD2 1 
ATOM   2630 N N   . ILE   B 2 391 ? 135.937 138.675 141.410 1.00 48.96  ? 253 ILE   R N   1 
ATOM   2631 C CA  . ILE   B 2 391 ? 134.822 137.761 141.196 1.00 52.26  ? 253 ILE   R CA  1 
ATOM   2632 C C   . ILE   B 2 391 ? 133.493 138.492 141.343 1.00 57.14  ? 253 ILE   R C   1 
ATOM   2633 O O   . ILE   B 2 391 ? 132.569 138.298 140.539 1.00 54.67  ? 253 ILE   R O   1 
ATOM   2634 C CB  . ILE   B 2 391 ? 134.936 136.566 142.158 1.00 54.53  ? 253 ILE   R CB  1 
ATOM   2635 C CG1 . ILE   B 2 391 ? 136.100 135.672 141.732 1.00 58.91  ? 253 ILE   R CG1 1 
ATOM   2636 C CG2 . ILE   B 2 391 ? 133.643 135.775 142.196 1.00 55.49  ? 253 ILE   R CG2 1 
ATOM   2637 C CD1 . ILE   B 2 391 ? 136.453 134.613 142.727 1.00 56.15  ? 253 ILE   R CD1 1 
ATOM   2638 N N   . LEU   B 2 392 ? 133.374 139.349 142.363 1.00 57.45  ? 254 LEU   R N   1 
ATOM   2639 C CA  . LEU   B 2 392 ? 132.134 140.094 142.549 1.00 52.69  ? 254 LEU   R CA  1 
ATOM   2640 C C   . LEU   B 2 392 ? 131.858 141.015 141.367 1.00 56.54  ? 254 LEU   R C   1 
ATOM   2641 O O   . LEU   B 2 392 ? 130.721 141.096 140.889 1.00 63.30  ? 254 LEU   R O   1 
ATOM   2642 C CB  . LEU   B 2 392 ? 132.188 140.893 143.848 1.00 55.29  ? 254 LEU   R CB  1 
ATOM   2643 C CG  . LEU   B 2 392 ? 130.948 141.733 144.154 1.00 58.55  ? 254 LEU   R CG  1 
ATOM   2644 C CD1 . LEU   B 2 392 ? 129.717 140.852 144.254 1.00 55.70  ? 254 LEU   R CD1 1 
ATOM   2645 C CD2 . LEU   B 2 392 ? 131.146 142.526 145.431 1.00 62.78  ? 254 LEU   R CD2 1 
ATOM   2646 N N   . ALA   B 2 393 ? 132.886 141.714 140.877 1.00 53.33  ? 255 ALA   R N   1 
ATOM   2647 C CA  . ALA   B 2 393 ? 132.700 142.592 139.727 1.00 44.06  ? 255 ALA   R CA  1 
ATOM   2648 C C   . ALA   B 2 393 ? 132.308 141.804 138.484 1.00 45.67  ? 255 ALA   R C   1 
ATOM   2649 O O   . ALA   B 2 393 ? 131.420 142.221 137.733 1.00 55.42  ? 255 ALA   R O   1 
ATOM   2650 C CB  . ALA   B 2 393 ? 133.971 143.398 139.470 1.00 49.78  ? 255 ALA   R CB  1 
ATOM   2651 N N   . PHE   B 2 394 ? 132.961 140.663 138.253 1.00 41.48  ? 256 PHE   R N   1 
ATOM   2652 C CA  . PHE   B 2 394 ? 132.640 139.826 137.101 1.00 39.59  ? 256 PHE   R CA  1 
ATOM   2653 C C   . PHE   B 2 394 ? 131.181 139.392 137.133 1.00 45.74  ? 256 PHE   R C   1 
ATOM   2654 O O   . PHE   B 2 394 ? 130.452 139.523 136.138 1.00 57.26  ? 256 PHE   R O   1 
ATOM   2655 C CB  . PHE   B 2 394 ? 133.571 138.612 137.092 1.00 50.27  ? 256 PHE   R CB  1 
ATOM   2656 C CG  . PHE   B 2 394 ? 133.492 137.778 135.846 1.00 52.74  ? 256 PHE   R CG  1 
ATOM   2657 C CD1 . PHE   B 2 394 ? 132.554 136.769 135.729 1.00 45.76  ? 256 PHE   R CD1 1 
ATOM   2658 C CD2 . PHE   B 2 394 ? 134.381 137.978 134.807 1.00 50.70  ? 256 PHE   R CD2 1 
ATOM   2659 C CE1 . PHE   B 2 394 ? 132.487 135.997 134.593 1.00 45.55  ? 256 PHE   R CE1 1 
ATOM   2660 C CE2 . PHE   B 2 394 ? 134.319 137.205 133.669 1.00 44.60  ? 256 PHE   R CE2 1 
ATOM   2661 C CZ  . PHE   B 2 394 ? 133.371 136.215 133.562 1.00 47.82  ? 256 PHE   R CZ  1 
ATOM   2662 N N   . PHE   B 2 395 ? 130.730 138.886 138.280 1.00 51.12  ? 257 PHE   R N   1 
ATOM   2663 C CA  . PHE   B 2 395 ? 129.365 138.384 138.350 1.00 53.76  ? 257 PHE   R CA  1 
ATOM   2664 C C   . PHE   B 2 395 ? 128.342 139.511 138.304 1.00 51.47  ? 257 PHE   R C   1 
ATOM   2665 O O   . PHE   B 2 395 ? 127.272 139.341 137.713 1.00 57.91  ? 257 PHE   R O   1 
ATOM   2666 C CB  . PHE   B 2 395 ? 129.191 137.518 139.593 1.00 54.26  ? 257 PHE   R CB  1 
ATOM   2667 C CG  . PHE   B 2 395 ? 129.677 136.110 139.407 1.00 59.46  ? 257 PHE   R CG  1 
ATOM   2668 C CD1 . PHE   B 2 395 ? 128.927 135.195 138.690 1.00 60.35  ? 257 PHE   R CD1 1 
ATOM   2669 C CD2 . PHE   B 2 395 ? 130.895 135.709 139.923 1.00 55.03  ? 257 PHE   R CD2 1 
ATOM   2670 C CE1 . PHE   B 2 395 ? 129.377 133.903 138.505 1.00 49.98  ? 257 PHE   R CE1 1 
ATOM   2671 C CE2 . PHE   B 2 395 ? 131.347 134.418 139.741 1.00 60.38  ? 257 PHE   R CE2 1 
ATOM   2672 C CZ  . PHE   B 2 395 ? 130.587 133.515 139.031 1.00 52.97  ? 257 PHE   R CZ  1 
ATOM   2673 N N   . ALA   B 2 396 ? 128.648 140.671 138.891 1.00 41.90  ? 258 ALA   R N   1 
ATOM   2674 C CA  . ALA   B 2 396 ? 127.736 141.805 138.783 1.00 36.92  ? 258 ALA   R CA  1 
ATOM   2675 C C   . ALA   B 2 396 ? 127.628 142.293 137.344 1.00 48.01  ? 258 ALA   R C   1 
ATOM   2676 O O   . ALA   B 2 396 ? 126.543 142.682 136.897 1.00 54.87  ? 258 ALA   R O   1 
ATOM   2677 C CB  . ALA   B 2 396 ? 128.191 142.937 139.700 1.00 45.73  ? 258 ALA   R CB  1 
ATOM   2678 N N   . CYS   B 2 397 ? 128.742 142.298 136.609 1.00 59.46  ? 259 CYS   R N   1 
ATOM   2679 C CA  . CYS   B 2 397 ? 128.701 142.692 135.205 1.00 49.96  ? 259 CYS   R CA  1 
ATOM   2680 C C   . CYS   B 2 397 ? 127.878 141.715 134.377 1.00 54.81  ? 259 CYS   R C   1 
ATOM   2681 O O   . CYS   B 2 397 ? 127.114 142.129 133.498 1.00 58.20  ? 259 CYS   R O   1 
ATOM   2682 C CB  . CYS   B 2 397 ? 130.117 142.798 134.642 1.00 43.23  ? 259 CYS   R CB  1 
ATOM   2683 S SG  . CYS   B 2 397 ? 130.983 144.321 135.057 1.00 70.56  ? 259 CYS   R SG  1 
ATOM   2684 N N   . TRP   B 2 398 ? 128.019 140.414 134.634 1.00 43.25  ? 260 TRP   R N   1 
ATOM   2685 C CA  . TRP   B 2 398 ? 127.362 139.429 133.784 1.00 41.61  ? 260 TRP   R CA  1 
ATOM   2686 C C   . TRP   B 2 398 ? 125.934 139.092 134.200 1.00 47.09  ? 260 TRP   R C   1 
ATOM   2687 O O   . TRP   B 2 398 ? 125.204 138.507 133.395 1.00 56.42  ? 260 TRP   R O   1 
ATOM   2688 C CB  . TRP   B 2 398 ? 128.184 138.138 133.738 1.00 43.76  ? 260 TRP   R CB  1 
ATOM   2689 C CG  . TRP   B 2 398 ? 129.175 138.103 132.618 1.00 44.11  ? 260 TRP   R CG  1 
ATOM   2690 C CD1 . TRP   B 2 398 ? 130.530 138.183 132.724 1.00 43.35  ? 260 TRP   R CD1 1 
ATOM   2691 C CD2 . TRP   B 2 398 ? 128.890 137.984 131.220 1.00 49.79  ? 260 TRP   R CD2 1 
ATOM   2692 N NE1 . TRP   B 2 398 ? 131.107 138.120 131.482 1.00 49.69  ? 260 TRP   R NE1 1 
ATOM   2693 C CE2 . TRP   B 2 398 ? 130.121 137.998 130.541 1.00 52.99  ? 260 TRP   R CE2 1 
ATOM   2694 C CE3 . TRP   B 2 398 ? 127.712 137.869 130.478 1.00 46.72  ? 260 TRP   R CE3 1 
ATOM   2695 C CZ2 . TRP   B 2 398 ? 130.209 137.901 129.156 1.00 53.24  ? 260 TRP   R CZ2 1 
ATOM   2696 C CZ3 . TRP   B 2 398 ? 127.803 137.773 129.104 1.00 46.72  ? 260 TRP   R CZ3 1 
ATOM   2697 C CH2 . TRP   B 2 398 ? 129.040 137.789 128.458 1.00 51.82  ? 260 TRP   R CH2 1 
ATOM   2698 N N   . LEU   B 2 399 ? 125.512 139.441 135.416 1.00 45.55  ? 261 LEU   R N   1 
ATOM   2699 C CA  . LEU   B 2 399 ? 124.217 138.969 135.909 1.00 48.72  ? 261 LEU   R CA  1 
ATOM   2700 C C   . LEU   B 2 399 ? 123.013 139.468 135.116 1.00 56.32  ? 261 LEU   R C   1 
ATOM   2701 O O   . LEU   B 2 399 ? 122.157 138.638 134.761 1.00 66.37  ? 261 LEU   R O   1 
ATOM   2702 C CB  . LEU   B 2 399 ? 124.072 139.325 137.391 1.00 49.60  ? 261 LEU   R CB  1 
ATOM   2703 C CG  . LEU   B 2 399 ? 122.857 138.689 138.062 1.00 45.92  ? 261 LEU   R CG  1 
ATOM   2704 C CD1 . LEU   B 2 399 ? 123.082 137.198 138.243 1.00 48.61  ? 261 LEU   R CD1 1 
ATOM   2705 C CD2 . LEU   B 2 399 ? 122.561 139.360 139.391 1.00 51.59  ? 261 LEU   R CD2 1 
ATOM   2706 N N   . PRO   B 2 400 ? 122.850 140.768 134.835 1.00 44.97  ? 262 PRO   R N   1 
ATOM   2707 C CA  . PRO   B 2 400 ? 121.623 141.199 134.143 1.00 49.47  ? 262 PRO   R CA  1 
ATOM   2708 C C   . PRO   B 2 400 ? 121.448 140.569 132.772 1.00 56.37  ? 262 PRO   R C   1 
ATOM   2709 O O   . PRO   B 2 400 ? 120.311 140.304 132.360 1.00 64.10  ? 262 PRO   R O   1 
ATOM   2710 C CB  . PRO   B 2 400 ? 121.784 142.723 134.059 1.00 47.51  ? 262 PRO   R CB  1 
ATOM   2711 C CG  . PRO   B 2 400 ? 122.783 143.066 135.093 1.00 51.15  ? 262 PRO   R CG  1 
ATOM   2712 C CD  . PRO   B 2 400 ? 123.723 141.914 135.138 1.00 50.35  ? 262 PRO   R CD  1 
ATOM   2713 N N   . TYR   B 2 401 ? 122.543 140.303 132.057 1.00 55.59  ? 263 TYR   R N   1 
ATOM   2714 C CA  . TYR   B 2 401 ? 122.441 139.570 130.801 1.00 44.90  ? 263 TYR   R CA  1 
ATOM   2715 C C   . TYR   B 2 401 ? 121.883 138.174 131.030 1.00 52.86  ? 263 TYR   R C   1 
ATOM   2716 O O   . TYR   B 2 401 ? 121.068 137.684 130.240 1.00 61.11  ? 263 TYR   R O   1 
ATOM   2717 C CB  . TYR   B 2 401 ? 123.809 139.494 130.127 1.00 49.32  ? 263 TYR   R CB  1 
ATOM   2718 C CG  . TYR   B 2 401 ? 123.863 138.546 128.951 1.00 53.57  ? 263 TYR   R CG  1 
ATOM   2719 C CD1 . TYR   B 2 401 ? 123.321 138.900 127.726 1.00 58.86  ? 263 TYR   R CD1 1 
ATOM   2720 C CD2 . TYR   B 2 401 ? 124.456 137.299 129.067 1.00 46.92  ? 263 TYR   R CD2 1 
ATOM   2721 C CE1 . TYR   B 2 401 ? 123.370 138.041 126.651 1.00 55.94  ? 263 TYR   R CE1 1 
ATOM   2722 C CE2 . TYR   B 2 401 ? 124.508 136.433 127.997 1.00 48.19  ? 263 TYR   R CE2 1 
ATOM   2723 C CZ  . TYR   B 2 401 ? 123.964 136.809 126.793 1.00 52.84  ? 263 TYR   R CZ  1 
ATOM   2724 O OH  . TYR   B 2 401 ? 124.012 135.949 125.722 1.00 59.15  ? 263 TYR   R OH  1 
ATOM   2725 N N   . TYR   B 2 402 ? 122.316 137.514 132.106 1.00 53.80  ? 264 TYR   R N   1 
ATOM   2726 C CA  . TYR   B 2 402 ? 121.811 136.179 132.407 1.00 45.52  ? 264 TYR   R CA  1 
ATOM   2727 C C   . TYR   B 2 402 ? 120.334 136.218 132.774 1.00 46.85  ? 264 TYR   R C   1 
ATOM   2728 O O   . TYR   B 2 402 ? 119.574 135.320 132.398 1.00 50.44  ? 264 TYR   R O   1 
ATOM   2729 C CB  . TYR   B 2 402 ? 122.641 135.543 133.520 1.00 40.49  ? 264 TYR   R CB  1 
ATOM   2730 C CG  . TYR   B 2 402 ? 123.965 135.007 133.030 1.00 48.42  ? 264 TYR   R CG  1 
ATOM   2731 C CD1 . TYR   B 2 402 ? 124.018 134.068 132.012 1.00 54.14  ? 264 TYR   R CD1 1 
ATOM   2732 C CD2 . TYR   B 2 402 ? 125.160 135.446 133.574 1.00 51.57  ? 264 TYR   R CD2 1 
ATOM   2733 C CE1 . TYR   B 2 402 ? 125.221 133.579 131.553 1.00 49.97  ? 264 TYR   R CE1 1 
ATOM   2734 C CE2 . TYR   B 2 402 ? 126.370 134.962 133.120 1.00 54.07  ? 264 TYR   R CE2 1 
ATOM   2735 C CZ  . TYR   B 2 402 ? 126.393 134.029 132.110 1.00 52.05  ? 264 TYR   R CZ  1 
ATOM   2736 O OH  . TYR   B 2 402 ? 127.594 133.541 131.654 1.00 53.18  ? 264 TYR   R OH  1 
ATOM   2737 N N   . ILE   B 2 403 ? 119.903 137.259 133.489 1.00 44.70  ? 265 ILE   R N   1 
ATOM   2738 C CA  . ILE   B 2 403 ? 118.480 137.414 133.787 1.00 50.52  ? 265 ILE   R CA  1 
ATOM   2739 C C   . ILE   B 2 403 ? 117.685 137.584 132.497 1.00 56.67  ? 265 ILE   R C   1 
ATOM   2740 O O   . ILE   B 2 403 ? 116.630 136.962 132.301 1.00 64.80  ? 265 ILE   R O   1 
ATOM   2741 C CB  . ILE   B 2 403 ? 118.260 138.600 134.743 1.00 46.71  ? 265 ILE   R CB  1 
ATOM   2742 C CG1 . ILE   B 2 403 ? 118.913 138.325 136.096 1.00 57.81  ? 265 ILE   R CG1 1 
ATOM   2743 C CG2 . ILE   B 2 403 ? 116.779 138.879 134.914 1.00 53.41  ? 265 ILE   R CG2 1 
ATOM   2744 C CD1 . ILE   B 2 403 ? 118.995 139.540 136.985 1.00 59.10  ? 265 ILE   R CD1 1 
ATOM   2745 N N   . GLY   B 2 404 ? 118.188 138.429 131.596 1.00 53.99  ? 266 GLY   R N   1 
ATOM   2746 C CA  . GLY   B 2 404 ? 117.505 138.637 130.331 1.00 48.23  ? 266 GLY   R CA  1 
ATOM   2747 C C   . GLY   B 2 404 ? 117.395 137.369 129.508 1.00 57.09  ? 266 GLY   R C   1 
ATOM   2748 O O   . GLY   B 2 404 ? 116.334 137.065 128.959 1.00 61.84  ? 266 GLY   R O   1 
ATOM   2749 N N   . ILE   B 2 405 ? 118.484 136.602 129.419 1.00 60.25  ? 267 ILE   R N   1 
ATOM   2750 C CA  . ILE   B 2 405 ? 118.432 135.387 128.612 1.00 52.90  ? 267 ILE   R CA  1 
ATOM   2751 C C   . ILE   B 2 405 ? 117.605 134.309 129.299 1.00 63.24  ? 267 ILE   R C   1 
ATOM   2752 O O   . ILE   B 2 405 ? 117.033 133.448 128.627 1.00 67.32  ? 267 ILE   R O   1 
ATOM   2753 C CB  . ILE   B 2 405 ? 119.842 134.879 128.262 1.00 50.56  ? 267 ILE   R CB  1 
ATOM   2754 C CG1 . ILE   B 2 405 ? 120.590 134.419 129.509 1.00 54.07  ? 267 ILE   R CG1 1 
ATOM   2755 C CG2 . ILE   B 2 405 ? 120.624 135.945 127.524 1.00 59.04  ? 267 ILE   R CG2 1 
ATOM   2756 C CD1 . ILE   B 2 405 ? 121.928 133.792 129.203 1.00 55.22  ? 267 ILE   R CD1 1 
ATOM   2757 N N   . SER   B 2 406 ? 117.503 134.333 130.630 1.00 61.68  ? 268 SER   R N   1 
ATOM   2758 C CA  . SER   B 2 406 ? 116.604 133.402 131.307 1.00 54.34  ? 268 SER   R CA  1 
ATOM   2759 C C   . SER   B 2 406 ? 115.148 133.706 130.971 1.00 60.26  ? 268 SER   R C   1 
ATOM   2760 O O   . SER   B 2 406 ? 114.364 132.796 130.666 1.00 62.51  ? 268 SER   R O   1 
ATOM   2761 C CB  . SER   B 2 406 ? 116.831 133.456 132.816 1.00 49.19  ? 268 SER   R CB  1 
ATOM   2762 O OG  . SER   B 2 406 ? 118.190 133.220 133.134 1.00 62.42  ? 268 SER   R OG  1 
ATOM   2763 N N   . ILE   B 2 407 ? 114.770 134.986 131.012 1.00 72.32  ? 269 ILE   R N   1 
ATOM   2764 C CA  . ILE   B 2 407 ? 113.410 135.356 130.622 1.00 66.99  ? 269 ILE   R CA  1 
ATOM   2765 C C   . ILE   B 2 407 ? 113.168 135.015 129.156 1.00 73.69  ? 269 ILE   R C   1 
ATOM   2766 O O   . ILE   B 2 407 ? 112.086 134.547 128.780 1.00 79.30  ? 269 ILE   R O   1 
ATOM   2767 C CB  . ILE   B 2 407 ? 113.147 136.846 130.905 1.00 68.26  ? 269 ILE   R CB  1 
ATOM   2768 C CG1 . ILE   B 2 407 ? 113.482 137.184 132.356 1.00 70.86  ? 269 ILE   R CG1 1 
ATOM   2769 C CG2 . ILE   B 2 407 ? 111.699 137.190 130.614 1.00 67.41  ? 269 ILE   R CG2 1 
ATOM   2770 C CD1 . ILE   B 2 407 ? 113.833 138.637 132.573 1.00 65.70  ? 269 ILE   R CD1 1 
ATOM   2771 N N   . ASP   B 2 408 ? 114.173 135.238 128.307 1.00 80.02  ? 270 ASP   R N   1 
ATOM   2772 C CA  . ASP   B 2 408 ? 114.036 134.908 126.892 1.00 75.82  ? 270 ASP   R CA  1 
ATOM   2773 C C   . ASP   B 2 408 ? 113.856 133.410 126.684 1.00 76.12  ? 270 ASP   R C   1 
ATOM   2774 O O   . ASP   B 2 408 ? 113.047 132.982 125.852 1.00 78.05  ? 270 ASP   R O   1 
ATOM   2775 C CB  . ASP   B 2 408 ? 115.257 135.409 126.126 1.00 74.51  ? 270 ASP   R CB  1 
ATOM   2776 C CG  . ASP   B 2 408 ? 114.983 135.589 124.656 1.00 84.05  ? 270 ASP   R CG  1 
ATOM   2777 O OD1 . ASP   B 2 408 ? 113.849 135.300 124.228 1.00 84.96  ? 270 ASP   R OD1 1 
ATOM   2778 O OD2 . ASP   B 2 408 ? 115.898 136.029 123.932 1.00 85.14  ? 270 ASP   R OD2 1 
ATOM   2779 N N   . SER   B 2 409 ? 114.613 132.597 127.422 1.00 75.80  ? 271 SER   R N   1 
ATOM   2780 C CA  . SER   B 2 409 ? 114.474 131.151 127.321 1.00 78.40  ? 271 SER   R CA  1 
ATOM   2781 C C   . SER   B 2 409 ? 113.089 130.709 127.762 1.00 78.98  ? 271 SER   R C   1 
ATOM   2782 O O   . SER   B 2 409 ? 112.482 129.830 127.141 1.00 82.18  ? 271 SER   R O   1 
ATOM   2783 C CB  . SER   B 2 409 ? 115.550 130.463 128.158 1.00 80.51  ? 271 SER   R CB  1 
ATOM   2784 O OG  . SER   B 2 409 ? 116.845 130.772 127.678 1.00 82.69  ? 271 SER   R OG  1 
ATOM   2785 N N   . PHE   B 2 410 ? 112.571 131.309 128.837 1.00 82.52  ? 272 PHE   R N   1 
ATOM   2786 C CA  . PHE   B 2 410 ? 111.213 130.983 129.258 1.00 84.49  ? 272 PHE   R CA  1 
ATOM   2787 C C   . PHE   B 2 410 ? 110.191 131.408 128.212 1.00 83.32  ? 272 PHE   R C   1 
ATOM   2788 O O   . PHE   B 2 410 ? 109.156 130.751 128.053 1.00 85.68  ? 272 PHE   R O   1 
ATOM   2789 C CB  . PHE   B 2 410 ? 110.907 131.628 130.609 1.00 82.48  ? 272 PHE   R CB  1 
ATOM   2790 C CG  . PHE   B 2 410 ? 111.495 130.887 131.773 1.00 84.49  ? 272 PHE   R CG  1 
ATOM   2791 C CD1 . PHE   B 2 410 ? 111.887 129.567 131.640 1.00 83.34  ? 272 PHE   R CD1 1 
ATOM   2792 C CD2 . PHE   B 2 410 ? 111.660 131.508 132.996 1.00 87.17  ? 272 PHE   R CD2 1 
ATOM   2793 C CE1 . PHE   B 2 410 ? 112.432 128.881 132.702 1.00 80.21  ? 272 PHE   R CE1 1 
ATOM   2794 C CE2 . PHE   B 2 410 ? 112.204 130.825 134.064 1.00 87.15  ? 272 PHE   R CE2 1 
ATOM   2795 C CZ  . PHE   B 2 410 ? 112.590 129.511 133.916 1.00 82.73  ? 272 PHE   R CZ  1 
ATOM   2796 N N   . ILE   B 2 411 ? 110.460 132.500 127.493 1.00 83.51  ? 273 ILE   R N   1 
ATOM   2797 C CA  . ILE   B 2 411 ? 109.607 132.872 126.367 1.00 81.83  ? 273 ILE   R CA  1 
ATOM   2798 C C   . ILE   B 2 411 ? 109.650 131.791 125.294 1.00 83.51  ? 273 ILE   R C   1 
ATOM   2799 O O   . ILE   B 2 411 ? 108.614 131.399 124.743 1.00 85.19  ? 273 ILE   R O   1 
ATOM   2800 C CB  . ILE   B 2 411 ? 110.023 134.244 125.805 1.00 83.18  ? 273 ILE   R CB  1 
ATOM   2801 C CG1 . ILE   B 2 411 ? 109.597 135.367 126.751 1.00 86.09  ? 273 ILE   R CG1 1 
ATOM   2802 C CG2 . ILE   B 2 411 ? 109.418 134.464 124.429 1.00 84.52  ? 273 ILE   R CG2 1 
ATOM   2803 C CD1 . ILE   B 2 411 ? 110.488 136.588 126.686 1.00 83.29  ? 273 ILE   R CD1 1 
ATOM   2804 N N   . LEU   B 2 412 ? 110.849 131.291 124.982 1.00 93.11  ? 274 LEU   R N   1 
ATOM   2805 C CA  . LEU   B 2 412 ? 110.974 130.187 124.034 1.00 93.45  ? 274 LEU   R CA  1 
ATOM   2806 C C   . LEU   B 2 412 ? 110.272 128.936 124.542 1.00 95.39  ? 274 LEU   R C   1 
ATOM   2807 O O   . LEU   B 2 412 ? 109.617 128.226 123.771 1.00 95.51  ? 274 LEU   R O   1 
ATOM   2808 C CB  . LEU   B 2 412 ? 112.447 129.893 123.755 1.00 93.44  ? 274 LEU   R CB  1 
ATOM   2809 C CG  . LEU   B 2 412 ? 113.180 130.898 122.873 1.00 95.83  ? 274 LEU   R CG  1 
ATOM   2810 C CD1 . LEU   B 2 412 ? 114.673 130.629 122.869 1.00 90.17  ? 274 LEU   R CD1 1 
ATOM   2811 C CD2 . LEU   B 2 412 ? 112.617 130.795 121.469 1.00 94.03  ? 274 LEU   R CD2 1 
ATOM   2812 N N   . LEU   B 2 413 ? 110.398 128.648 125.837 1.00 94.60  ? 275 LEU   R N   1 
ATOM   2813 C CA  . LEU   B 2 413 ? 109.732 127.490 126.421 1.00 92.32  ? 275 LEU   R CA  1 
ATOM   2814 C C   . LEU   B 2 413 ? 108.222 127.659 126.509 1.00 96.01  ? 275 LEU   R C   1 
ATOM   2815 O O   . LEU   B 2 413 ? 107.547 126.753 127.012 1.00 95.58  ? 275 LEU   R O   1 
ATOM   2816 C CB  . LEU   B 2 413 ? 110.309 127.205 127.808 1.00 89.63  ? 275 LEU   R CB  1 
ATOM   2817 C CG  . LEU   B 2 413 ? 111.781 126.790 127.826 1.00 89.46  ? 275 LEU   R CG  1 
ATOM   2818 C CD1 . LEU   B 2 413 ? 112.274 126.596 129.249 1.00 92.74  ? 275 LEU   R CD1 1 
ATOM   2819 C CD2 . LEU   B 2 413 ? 111.988 125.529 127.007 1.00 92.02  ? 275 LEU   R CD2 1 
ATOM   2820 N N   . GLU   B 2 414 ? 107.687 128.790 126.049 1.00 103.93 ? 276 GLU   R N   1 
ATOM   2821 C CA  . GLU   B 2 414 ? 106.258 129.074 125.960 1.00 102.43 ? 276 GLU   R CA  1 
ATOM   2822 C C   . GLU   B 2 414 ? 105.578 129.135 127.321 1.00 102.49 ? 276 GLU   R C   1 
ATOM   2823 O O   . GLU   B 2 414 ? 104.343 129.117 127.392 1.00 105.99 ? 276 GLU   R O   1 
ATOM   2824 C CB  . GLU   B 2 414 ? 105.540 128.059 125.060 1.00 103.21 ? 276 GLU   R CB  1 
ATOM   2825 C CG  . GLU   B 2 414 ? 106.184 127.893 123.692 1.00 104.50 ? 276 GLU   R CG  1 
ATOM   2826 C CD  . GLU   B 2 414 ? 105.190 127.499 122.619 1.00 106.55 ? 276 GLU   R CD  1 
ATOM   2827 O OE1 . GLU   B 2 414 ? 103.971 127.570 122.880 1.00 107.39 ? 276 GLU   R OE1 1 
ATOM   2828 O OE2 . GLU   B 2 414 ? 105.629 127.119 121.513 1.00 105.22 ? 276 GLU   R OE2 1 
ATOM   2829 N N   . ILE   B 2 415 ? 106.347 129.200 128.409 1.00 98.35  ? 277 ILE   R N   1 
ATOM   2830 C CA  . ILE   B 2 415 ? 105.745 129.371 129.726 1.00 99.76  ? 277 ILE   R CA  1 
ATOM   2831 C C   . ILE   B 2 415 ? 105.182 130.779 129.876 1.00 101.95 ? 277 ILE   R C   1 
ATOM   2832 O O   . ILE   B 2 415 ? 104.057 130.965 130.354 1.00 102.39 ? 277 ILE   R O   1 
ATOM   2833 C CB  . ILE   B 2 415 ? 106.771 129.046 130.826 1.00 101.90 ? 277 ILE   R CB  1 
ATOM   2834 C CG1 . ILE   B 2 415 ? 107.046 127.543 130.866 1.00 103.41 ? 277 ILE   R CG1 1 
ATOM   2835 C CG2 . ILE   B 2 415 ? 106.276 129.531 132.180 1.00 100.17 ? 277 ILE   R CG2 1 
ATOM   2836 C CD1 . ILE   B 2 415 ? 108.079 127.139 131.893 1.00 100.70 ? 277 ILE   R CD1 1 
ATOM   2837 N N   . ILE   B 2 416 ? 105.943 131.787 129.458 1.00 102.61 ? 278 ILE   R N   1 
ATOM   2838 C CA  . ILE   B 2 416 ? 105.537 133.184 129.566 1.00 103.14 ? 278 ILE   R CA  1 
ATOM   2839 C C   . ILE   B 2 416 ? 104.903 133.599 128.247 1.00 102.56 ? 278 ILE   R C   1 
ATOM   2840 O O   . ILE   B 2 416 ? 105.529 133.492 127.186 1.00 103.33 ? 278 ILE   R O   1 
ATOM   2841 C CB  . ILE   B 2 416 ? 106.728 134.090 129.913 1.00 99.52  ? 278 ILE   R CB  1 
ATOM   2842 C CG1 . ILE   B 2 416 ? 107.315 133.710 131.272 1.00 99.63  ? 278 ILE   R CG1 1 
ATOM   2843 C CG2 . ILE   B 2 416 ? 106.305 135.548 129.905 1.00 98.29  ? 278 ILE   R CG2 1 
ATOM   2844 C CD1 . ILE   B 2 416 ? 108.546 134.503 131.642 1.00 100.34 ? 278 ILE   R CD1 1 
ATOM   2845 N N   . LYS   B 2 417 ? 103.662 134.075 128.309 1.00 101.49 ? 279 LYS   R N   1 
ATOM   2846 C CA  . LYS   B 2 417 ? 102.922 134.507 127.130 1.00 101.55 ? 279 LYS   R CA  1 
ATOM   2847 C C   . LYS   B 2 417 ? 102.500 135.957 127.310 1.00 100.47 ? 279 LYS   R C   1 
ATOM   2848 O O   . LYS   B 2 417 ? 101.752 136.278 128.240 1.00 100.12 ? 279 LYS   R O   1 
ATOM   2849 C CB  . LYS   B 2 417 ? 101.700 133.617 126.893 1.00 103.69 ? 279 LYS   R CB  1 
ATOM   2850 C CG  . LYS   B 2 417 ? 102.038 132.171 126.578 1.00 100.90 ? 279 LYS   R CG  1 
ATOM   2851 C CD  . LYS   B 2 417 ? 102.723 132.054 125.227 1.00 100.77 ? 279 LYS   R CD  1 
ATOM   2852 C CE  . LYS   B 2 417 ? 102.968 130.602 124.855 1.00 101.93 ? 279 LYS   R CE  1 
ATOM   2853 N NZ  . LYS   B 2 417 ? 103.680 130.470 123.553 1.00 101.07 ? 279 LYS   R NZ  1 
ATOM   2854 N N   . GLN   B 2 418 ? 102.976 136.824 126.420 1.00 108.86 ? 280 GLN   R N   1 
ATOM   2855 C CA  . GLN   B 2 418 ? 102.607 138.232 126.403 1.00 110.01 ? 280 GLN   R CA  1 
ATOM   2856 C C   . GLN   B 2 418 ? 102.546 138.696 124.953 1.00 110.95 ? 280 GLN   R C   1 
ATOM   2857 O O   . GLN   B 2 418 ? 102.709 137.905 124.018 1.00 108.46 ? 280 GLN   R O   1 
ATOM   2858 C CB  . GLN   B 2 418 ? 103.595 139.086 127.209 1.00 110.45 ? 280 GLN   R CB  1 
ATOM   2859 C CG  . GLN   B 2 418 ? 103.597 138.825 128.707 1.00 109.65 ? 280 GLN   R CG  1 
ATOM   2860 C CD  . GLN   B 2 418 ? 102.510 139.588 129.438 1.00 110.09 ? 280 GLN   R CD  1 
ATOM   2861 O OE1 . GLN   B 2 418 ? 101.623 140.175 128.819 1.00 110.22 ? 280 GLN   R OE1 1 
ATOM   2862 N NE2 . GLN   B 2 418 ? 102.574 139.582 130.764 1.00 110.53 ? 280 GLN   R NE2 1 
ATOM   2863 N N   . GLY   B 2 419 ? 102.310 139.994 124.764 1.00 115.64 ? 281 GLY   R N   1 
ATOM   2864 C CA  . GLY   B 2 419 ? 102.298 140.552 123.431 1.00 115.08 ? 281 GLY   R CA  1 
ATOM   2865 C C   . GLY   B 2 419 ? 103.694 140.745 122.868 1.00 114.20 ? 281 GLY   R C   1 
ATOM   2866 O O   . GLY   B 2 419 ? 104.688 140.764 123.592 1.00 113.83 ? 281 GLY   R O   1 
ATOM   2867 N N   . CYS   B 2 420 ? 103.756 140.905 121.542 1.00 114.52 ? 282 CYS   R N   1 
ATOM   2868 C CA  . CYS   B 2 420 ? 105.039 141.051 120.861 1.00 114.47 ? 282 CYS   R CA  1 
ATOM   2869 C C   . CYS   B 2 420 ? 105.822 142.261 121.352 1.00 114.44 ? 282 CYS   R C   1 
ATOM   2870 O O   . CYS   B 2 420 ? 107.050 142.292 121.207 1.00 115.00 ? 282 CYS   R O   1 
ATOM   2871 C CB  . CYS   B 2 420 ? 104.823 141.148 119.350 1.00 114.17 ? 282 CYS   R CB  1 
ATOM   2872 S SG  . CYS   B 2 420 ? 103.887 139.774 118.642 1.00 119.15 ? 282 CYS   R SG  1 
ATOM   2873 N N   . GLU   B 2 421 ? 105.142 143.254 121.928 1.00 114.01 ? 283 GLU   R N   1 
ATOM   2874 C CA  . GLU   B 2 421 ? 105.850 144.367 122.548 1.00 114.05 ? 283 GLU   R CA  1 
ATOM   2875 C C   . GLU   B 2 421 ? 106.754 143.875 123.669 1.00 113.69 ? 283 GLU   R C   1 
ATOM   2876 O O   . GLU   B 2 421 ? 107.880 144.362 123.830 1.00 112.44 ? 283 GLU   R O   1 
ATOM   2877 C CB  . GLU   B 2 421 ? 104.851 145.396 123.076 1.00 114.83 ? 283 GLU   R CB  1 
ATOM   2878 C CG  . GLU   B 2 421 ? 105.489 146.672 123.599 1.00 116.09 ? 283 GLU   R CG  1 
ATOM   2879 C CD  . GLU   B 2 421 ? 104.504 147.554 124.341 1.00 116.41 ? 283 GLU   R CD  1 
ATOM   2880 O OE1 . GLU   B 2 421 ? 103.314 147.182 124.420 1.00 116.13 ? 283 GLU   R OE1 1 
ATOM   2881 O OE2 . GLU   B 2 421 ? 104.918 148.619 124.843 1.00 115.22 ? 283 GLU   R OE2 1 
ATOM   2882 N N   . PHE   B 2 422 ? 106.278 142.903 124.452 1.00 99.30  ? 284 PHE   R N   1 
ATOM   2883 C CA  . PHE   B 2 422 ? 107.089 142.349 125.530 1.00 95.99  ? 284 PHE   R CA  1 
ATOM   2884 C C   . PHE   B 2 422 ? 108.344 141.676 124.988 1.00 97.33  ? 284 PHE   R C   1 
ATOM   2885 O O   . PHE   B 2 422 ? 109.441 141.875 125.523 1.00 96.39  ? 284 PHE   R O   1 
ATOM   2886 C CB  . PHE   B 2 422 ? 106.257 141.366 126.350 1.00 93.64  ? 284 PHE   R CB  1 
ATOM   2887 C CG  . PHE   B 2 422 ? 106.916 140.926 127.622 1.00 95.73  ? 284 PHE   R CG  1 
ATOM   2888 C CD1 . PHE   B 2 422 ? 107.326 141.854 128.561 1.00 97.93  ? 284 PHE   R CD1 1 
ATOM   2889 C CD2 . PHE   B 2 422 ? 107.115 139.583 127.885 1.00 98.50  ? 284 PHE   R CD2 1 
ATOM   2890 C CE1 . PHE   B 2 422 ? 107.931 141.451 129.734 1.00 96.62  ? 284 PHE   R CE1 1 
ATOM   2891 C CE2 . PHE   B 2 422 ? 107.718 139.175 129.056 1.00 99.04  ? 284 PHE   R CE2 1 
ATOM   2892 C CZ  . PHE   B 2 422 ? 108.126 140.111 129.982 1.00 96.62  ? 284 PHE   R CZ  1 
ATOM   2893 N N   . GLU   B 2 423 ? 108.206 140.884 123.921 1.00 105.12 ? 285 GLU   R N   1 
ATOM   2894 C CA  . GLU   B 2 423 ? 109.373 140.229 123.337 1.00 104.46 ? 285 GLU   R CA  1 
ATOM   2895 C C   . GLU   B 2 423 ? 110.351 141.244 122.757 1.00 102.68 ? 285 GLU   R C   1 
ATOM   2896 O O   . GLU   B 2 423 ? 111.568 141.092 122.908 1.00 101.68 ? 285 GLU   R O   1 
ATOM   2897 C CB  . GLU   B 2 423 ? 108.947 139.224 122.266 1.00 101.02 ? 285 GLU   R CB  1 
ATOM   2898 C CG  . GLU   B 2 423 ? 108.567 137.856 122.808 1.00 101.80 ? 285 GLU   R CG  1 
ATOM   2899 C CD  . GLU   B 2 423 ? 107.101 137.749 123.164 1.00 106.34 ? 285 GLU   R CD  1 
ATOM   2900 O OE1 . GLU   B 2 423 ? 106.349 138.696 122.862 1.00 107.56 ? 285 GLU   R OE1 1 
ATOM   2901 O OE2 . GLU   B 2 423 ? 106.702 136.721 123.748 1.00 106.00 ? 285 GLU   R OE2 1 
ATOM   2902 N N   . ASN   B 2 424 ? 109.844 142.279 122.085 1.00 95.65  ? 286 ASN   R N   1 
ATOM   2903 C CA  . ASN   B 2 424 ? 110.734 143.300 121.541 1.00 94.82  ? 286 ASN   R CA  1 
ATOM   2904 C C   . ASN   B 2 424 ? 111.483 144.026 122.653 1.00 95.34  ? 286 ASN   R C   1 
ATOM   2905 O O   . ASN   B 2 424 ? 112.691 144.280 122.540 1.00 96.40  ? 286 ASN   R O   1 
ATOM   2906 C CB  . ASN   B 2 424 ? 109.941 144.291 120.691 1.00 93.81  ? 286 ASN   R CB  1 
ATOM   2907 C CG  . ASN   B 2 424 ? 109.444 143.678 119.400 1.00 96.65  ? 286 ASN   R CG  1 
ATOM   2908 O OD1 . ASN   B 2 424 ? 110.076 142.782 118.842 1.00 96.27  ? 286 ASN   R OD1 1 
ATOM   2909 N ND2 . ASN   B 2 424 ? 108.304 144.159 118.917 1.00 98.51  ? 286 ASN   R ND2 1 
ATOM   2910 N N   . THR   B 2 425 ? 110.782 144.365 123.737 1.00 90.08  ? 287 THR   R N   1 
ATOM   2911 C CA  . THR   B 2 425 ? 111.435 145.021 124.862 1.00 90.38  ? 287 THR   R CA  1 
ATOM   2912 C C   . THR   B 2 425 ? 112.493 144.117 125.478 1.00 91.59  ? 287 THR   R C   1 
ATOM   2913 O O   . THR   B 2 425 ? 113.589 144.576 125.823 1.00 92.88  ? 287 THR   R O   1 
ATOM   2914 C CB  . THR   B 2 425 ? 110.399 145.425 125.910 1.00 90.56  ? 287 THR   R CB  1 
ATOM   2915 O OG1 . THR   B 2 425 ? 109.409 146.264 125.303 1.00 93.21  ? 287 THR   R OG1 1 
ATOM   2916 C CG2 . THR   B 2 425 ? 111.061 146.183 127.048 1.00 89.27  ? 287 THR   R CG2 1 
ATOM   2917 N N   . VAL   B 2 426 ? 112.188 142.823 125.606 1.00 81.15  ? 288 VAL   R N   1 
ATOM   2918 C CA  . VAL   B 2 426 ? 113.151 141.882 126.171 1.00 78.55  ? 288 VAL   R CA  1 
ATOM   2919 C C   . VAL   B 2 426 ? 114.376 141.767 125.274 1.00 81.37  ? 288 VAL   R C   1 
ATOM   2920 O O   . VAL   B 2 426 ? 115.509 141.685 125.757 1.00 82.60  ? 288 VAL   R O   1 
ATOM   2921 C CB  . VAL   B 2 426 ? 112.485 140.514 126.406 1.00 77.50  ? 288 VAL   R CB  1 
ATOM   2922 C CG1 . VAL   B 2 426 ? 113.528 139.419 126.514 1.00 73.46  ? 288 VAL   R CG1 1 
ATOM   2923 C CG2 . VAL   B 2 426 ? 111.634 140.558 127.662 1.00 81.08  ? 288 VAL   R CG2 1 
ATOM   2924 N N   . HIS   B 2 427 ? 114.173 141.762 123.955 1.00 79.38  ? 289 HIS   R N   1 
ATOM   2925 C CA  . HIS   B 2 427 ? 115.306 141.664 123.039 1.00 77.78  ? 289 HIS   R CA  1 
ATOM   2926 C C   . HIS   B 2 427 ? 116.190 142.904 123.104 1.00 80.66  ? 289 HIS   R C   1 
ATOM   2927 O O   . HIS   B 2 427 ? 117.424 142.794 123.097 1.00 80.29  ? 289 HIS   R O   1 
ATOM   2928 C CB  . HIS   B 2 427 ? 114.811 141.429 121.616 1.00 71.66  ? 289 HIS   R CB  1 
ATOM   2929 C CG  . HIS   B 2 427 ? 114.647 139.984 121.273 1.00 70.41  ? 289 HIS   R CG  1 
ATOM   2930 N ND1 . HIS   B 2 427 ? 113.682 139.530 120.402 1.00 76.31  ? 289 HIS   R ND1 1 
ATOM   2931 C CD2 . HIS   B 2 427 ? 115.323 138.889 121.690 1.00 75.71  ? 289 HIS   R CD2 1 
ATOM   2932 C CE1 . HIS   B 2 427 ? 113.773 138.217 120.294 1.00 82.54  ? 289 HIS   R CE1 1 
ATOM   2933 N NE2 . HIS   B 2 427 ? 114.760 137.803 121.067 1.00 80.55  ? 289 HIS   R NE2 1 
ATOM   2934 N N   . LYS   B 2 428 ? 115.584 144.093 123.158 1.00 74.06  ? 290 LYS   R N   1 
ATOM   2935 C CA  . LYS   B 2 428 ? 116.380 145.305 123.331 1.00 67.46  ? 290 LYS   R CA  1 
ATOM   2936 C C   . LYS   B 2 428 ? 117.150 145.262 124.645 1.00 72.29  ? 290 LYS   R C   1 
ATOM   2937 O O   . LYS   B 2 428 ? 118.340 145.608 124.695 1.00 73.87  ? 290 LYS   R O   1 
ATOM   2938 C CB  . LYS   B 2 428 ? 115.483 146.540 123.279 1.00 68.39  ? 290 LYS   R CB  1 
ATOM   2939 C CG  . LYS   B 2 428 ? 114.689 146.689 121.996 1.00 71.96  ? 290 LYS   R CG  1 
ATOM   2940 C CD  . LYS   B 2 428 ? 113.402 147.458 122.243 1.00 74.36  ? 290 LYS   R CD  1 
ATOM   2941 C CE  . LYS   B 2 428 ? 112.779 147.931 120.941 1.00 74.82  ? 290 LYS   R CE  1 
ATOM   2942 N NZ  . LYS   B 2 428 ? 111.524 148.696 121.177 1.00 73.69  ? 290 LYS   R NZ  1 
ATOM   2943 N N   . TRP   B 2 429 ? 116.479 144.833 125.717 1.00 59.33  ? 291 TRP   R N   1 
ATOM   2944 C CA  . TRP   B 2 429 ? 117.123 144.670 127.014 1.00 53.27  ? 291 TRP   R CA  1 
ATOM   2945 C C   . TRP   B 2 429 ? 118.336 143.755 126.910 1.00 58.62  ? 291 TRP   R C   1 
ATOM   2946 O O   . TRP   B 2 429 ? 119.419 144.087 127.399 1.00 69.76  ? 291 TRP   R O   1 
ATOM   2947 C CB  . TRP   B 2 429 ? 116.099 144.121 128.014 1.00 58.96  ? 291 TRP   R CB  1 
ATOM   2948 C CG  . TRP   B 2 429 ? 116.641 143.682 129.349 1.00 65.29  ? 291 TRP   R CG  1 
ATOM   2949 C CD1 . TRP   B 2 429 ? 117.359 142.551 129.613 1.00 65.81  ? 291 TRP   R CD1 1 
ATOM   2950 C CD2 . TRP   B 2 429 ? 116.464 144.343 130.606 1.00 64.29  ? 291 TRP   R CD2 1 
ATOM   2951 N NE1 . TRP   B 2 429 ? 117.662 142.483 130.949 1.00 58.36  ? 291 TRP   R NE1 1 
ATOM   2952 C CE2 . TRP   B 2 429 ? 117.122 143.570 131.582 1.00 62.33  ? 291 TRP   R CE2 1 
ATOM   2953 C CE3 . TRP   B 2 429 ? 115.825 145.522 131.000 1.00 64.18  ? 291 TRP   R CE3 1 
ATOM   2954 C CZ2 . TRP   B 2 429 ? 117.159 143.935 132.923 1.00 67.24  ? 291 TRP   R CZ2 1 
ATOM   2955 C CZ3 . TRP   B 2 429 ? 115.862 145.883 132.333 1.00 65.59  ? 291 TRP   R CZ3 1 
ATOM   2956 C CH2 . TRP   B 2 429 ? 116.525 145.093 133.278 1.00 70.15  ? 291 TRP   R CH2 1 
ATOM   2957 N N   . ILE   B 2 430 ? 118.172 142.602 126.259 1.00 51.98  ? 292 ILE   R N   1 
ATOM   2958 C CA  . ILE   B 2 430 ? 119.251 141.622 126.179 1.00 55.91  ? 292 ILE   R CA  1 
ATOM   2959 C C   . ILE   B 2 430 ? 120.416 142.160 125.362 1.00 66.28  ? 292 ILE   R C   1 
ATOM   2960 O O   . ILE   B 2 430 ? 121.579 141.987 125.738 1.00 66.47  ? 292 ILE   R O   1 
ATOM   2961 C CB  . ILE   B 2 430 ? 118.737 140.293 125.603 1.00 52.74  ? 292 ILE   R CB  1 
ATOM   2962 C CG1 . ILE   B 2 430 ? 117.752 139.636 126.562 1.00 61.77  ? 292 ILE   R CG1 1 
ATOM   2963 C CG2 . ILE   B 2 430 ? 119.892 139.351 125.333 1.00 58.41  ? 292 ILE   R CG2 1 
ATOM   2964 C CD1 . ILE   B 2 430 ? 117.198 138.345 126.038 1.00 65.33  ? 292 ILE   R CD1 1 
ATOM   2965 N N   . SER   B 2 431 ? 120.134 142.803 124.228 1.00 62.48  ? 293 SER   R N   1 
ATOM   2966 C CA  . SER   B 2 431 ? 121.216 143.319 123.393 1.00 51.63  ? 293 SER   R CA  1 
ATOM   2967 C C   . SER   B 2 431 ? 122.015 144.389 124.129 1.00 56.55  ? 293 SER   R C   1 
ATOM   2968 O O   . SER   B 2 431 ? 123.255 144.342 124.175 1.00 57.57  ? 293 SER   R O   1 
ATOM   2969 C CB  . SER   B 2 431 ? 120.649 143.869 122.087 1.00 62.21  ? 293 SER   R CB  1 
ATOM   2970 O OG  . SER   B 2 431 ? 121.656 144.516 121.331 1.00 71.41  ? 293 SER   R OG  1 
ATOM   2971 N N   . ILE   B 2 432 ? 121.317 145.356 124.732 1.00 59.14  ? 294 ILE   R N   1 
ATOM   2972 C CA  . ILE   B 2 432 ? 122.003 146.419 125.460 1.00 53.86  ? 294 ILE   R CA  1 
ATOM   2973 C C   . ILE   B 2 432 ? 122.783 145.842 126.633 1.00 60.45  ? 294 ILE   R C   1 
ATOM   2974 O O   . ILE   B 2 432 ? 123.929 146.235 126.894 1.00 67.70  ? 294 ILE   R O   1 
ATOM   2975 C CB  . ILE   B 2 432 ? 120.991 147.485 125.917 1.00 52.51  ? 294 ILE   R CB  1 
ATOM   2976 C CG1 . ILE   B 2 432 ? 120.410 148.213 124.705 1.00 58.23  ? 294 ILE   R CG1 1 
ATOM   2977 C CG2 . ILE   B 2 432 ? 121.641 148.472 126.865 1.00 64.00  ? 294 ILE   R CG2 1 
ATOM   2978 C CD1 . ILE   B 2 432 ? 119.402 149.277 125.060 1.00 63.53  ? 294 ILE   R CD1 1 
ATOM   2979 N N   . THR   B 2 433 ? 122.189 144.885 127.347 1.00 47.29  ? 295 THR   R N   1 
ATOM   2980 C CA  . THR   B 2 433 ? 122.840 144.330 128.522 1.00 37.33  ? 295 THR   R CA  1 
ATOM   2981 C C   . THR   B 2 433 ? 124.041 143.472 128.159 1.00 54.15  ? 295 THR   R C   1 
ATOM   2982 O O   . THR   B 2 433 ? 125.007 143.427 128.918 1.00 59.26  ? 295 THR   R O   1 
ATOM   2983 C CB  . THR   B 2 433 ? 121.841 143.521 129.338 1.00 52.27  ? 295 THR   R CB  1 
ATOM   2984 O OG1 . THR   B 2 433 ? 120.602 144.235 129.417 1.00 55.92  ? 295 THR   R OG1 1 
ATOM   2985 C CG2 . THR   B 2 433 ? 122.371 143.316 130.724 1.00 59.62  ? 295 THR   R CG2 1 
ATOM   2986 N N   . GLU   B 2 434 ? 124.008 142.785 127.017 1.00 59.41  ? 296 GLU   R N   1 
ATOM   2987 C CA  . GLU   B 2 434 ? 125.188 142.052 126.567 1.00 51.51  ? 296 GLU   R CA  1 
ATOM   2988 C C   . GLU   B 2 434 ? 126.310 143.006 126.180 1.00 54.80  ? 296 GLU   R C   1 
ATOM   2989 O O   . GLU   B 2 434 ? 127.480 142.778 126.526 1.00 54.91  ? 296 GLU   R O   1 
ATOM   2990 C CB  . GLU   B 2 434 ? 124.824 141.147 125.394 1.00 49.59  ? 296 GLU   R CB  1 
ATOM   2991 C CG  . GLU   B 2 434 ? 125.999 140.412 124.785 1.00 57.24  ? 296 GLU   R CG  1 
ATOM   2992 C CD  . GLU   B 2 434 ? 125.681 139.852 123.416 1.00 61.66  ? 296 GLU   R CD  1 
ATOM   2993 O OE1 . GLU   B 2 434 ? 125.344 140.644 122.513 1.00 62.37  ? 296 GLU   R OE1 1 
ATOM   2994 O OE2 . GLU   B 2 434 ? 125.766 138.619 123.241 1.00 60.43  ? 296 GLU   R OE2 1 
ATOM   2995 N N   . ALA   B 2 435 ? 125.972 144.086 125.470 1.00 58.57  ? 297 ALA   R N   1 
ATOM   2996 C CA  . ALA   B 2 435 ? 126.983 145.086 125.149 1.00 52.20  ? 297 ALA   R CA  1 
ATOM   2997 C C   . ALA   B 2 435 ? 127.608 145.659 126.415 1.00 52.47  ? 297 ALA   R C   1 
ATOM   2998 O O   . ALA   B 2 435 ? 128.819 145.902 126.463 1.00 53.59  ? 297 ALA   R O   1 
ATOM   2999 C CB  . ALA   B 2 435 ? 126.375 146.198 124.297 1.00 47.00  ? 297 ALA   R CB  1 
ATOM   3000 N N   . LEU   B 2 436 ? 126.798 145.876 127.453 1.00 47.85  ? 298 LEU   R N   1 
ATOM   3001 C CA  . LEU   B 2 436 ? 127.336 146.392 128.709 1.00 47.89  ? 298 LEU   R CA  1 
ATOM   3002 C C   . LEU   B 2 436 ? 128.097 145.326 129.492 1.00 54.18  ? 298 LEU   R C   1 
ATOM   3003 O O   . LEU   B 2 436 ? 129.047 145.651 130.211 1.00 61.92  ? 298 LEU   R O   1 
ATOM   3004 C CB  . LEU   B 2 436 ? 126.213 146.974 129.565 1.00 48.30  ? 298 LEU   R CB  1 
ATOM   3005 C CG  . LEU   B 2 436 ? 125.716 148.359 129.156 1.00 53.00  ? 298 LEU   R CG  1 
ATOM   3006 C CD1 . LEU   B 2 436 ? 124.581 148.802 130.057 1.00 55.04  ? 298 LEU   R CD1 1 
ATOM   3007 C CD2 . LEU   B 2 436 ? 126.852 149.359 129.197 1.00 55.84  ? 298 LEU   R CD2 1 
ATOM   3008 N N   . ALA   B 2 437 ? 127.696 144.059 129.378 1.00 50.69  ? 299 ALA   R N   1 
ATOM   3009 C CA  . ALA   B 2 437 ? 128.369 142.982 130.090 1.00 46.03  ? 299 ALA   R CA  1 
ATOM   3010 C C   . ALA   B 2 437 ? 129.713 142.644 129.473 1.00 51.69  ? 299 ALA   R C   1 
ATOM   3011 O O   . ALA   B 2 437 ? 130.543 142.012 130.132 1.00 43.21  ? 299 ALA   R O   1 
ATOM   3012 C CB  . ALA   B 2 437 ? 127.488 141.736 130.120 1.00 44.97  ? 299 ALA   R CB  1 
ATOM   3013 N N   . PHE   B 2 438 ? 129.939 143.043 128.221 1.00 68.78  ? 300 PHE   R N   1 
ATOM   3014 C CA  . PHE   B 2 438 ? 131.273 142.915 127.641 1.00 60.92  ? 300 PHE   R CA  1 
ATOM   3015 C C   . PHE   B 2 438 ? 132.321 143.736 128.383 1.00 55.11  ? 300 PHE   R C   1 
ATOM   3016 O O   . PHE   B 2 438 ? 133.505 143.644 128.046 1.00 51.14  ? 300 PHE   R O   1 
ATOM   3017 C CB  . PHE   B 2 438 ? 131.257 143.328 126.171 1.00 50.96  ? 300 PHE   R CB  1 
ATOM   3018 C CG  . PHE   B 2 438 ? 130.741 142.266 125.254 1.00 49.27  ? 300 PHE   R CG  1 
ATOM   3019 C CD1 . PHE   B 2 438 ? 130.537 140.979 125.712 1.00 50.28  ? 300 PHE   R CD1 1 
ATOM   3020 C CD2 . PHE   B 2 438 ? 130.453 142.555 123.934 1.00 51.28  ? 300 PHE   R CD2 1 
ATOM   3021 C CE1 . PHE   B 2 438 ? 130.056 140.002 124.871 1.00 55.44  ? 300 PHE   R CE1 1 
ATOM   3022 C CE2 . PHE   B 2 438 ? 129.973 141.582 123.091 1.00 47.62  ? 300 PHE   R CE2 1 
ATOM   3023 C CZ  . PHE   B 2 438 ? 129.775 140.304 123.559 1.00 50.70  ? 300 PHE   R CZ  1 
ATOM   3024 N N   . PHE   B 2 439 ? 131.920 144.536 129.374 1.00 55.76  ? 301 PHE   R N   1 
ATOM   3025 C CA  . PHE   B 2 439 ? 132.858 145.307 130.180 1.00 47.88  ? 301 PHE   R CA  1 
ATOM   3026 C C   . PHE   B 2 439 ? 133.709 144.437 131.092 1.00 58.72  ? 301 PHE   R C   1 
ATOM   3027 O O   . PHE   B 2 439 ? 134.642 144.956 131.713 1.00 69.93  ? 301 PHE   R O   1 
ATOM   3028 C CB  . PHE   B 2 439 ? 132.110 146.337 131.028 1.00 48.09  ? 301 PHE   R CB  1 
ATOM   3029 C CG  . PHE   B 2 439 ? 132.019 147.695 130.398 1.00 58.94  ? 301 PHE   R CG  1 
ATOM   3030 C CD1 . PHE   B 2 439 ? 133.096 148.560 130.432 1.00 63.32  ? 301 PHE   R CD1 1 
ATOM   3031 C CD2 . PHE   B 2 439 ? 130.853 148.112 129.782 1.00 61.80  ? 301 PHE   R CD2 1 
ATOM   3032 C CE1 . PHE   B 2 439 ? 133.014 149.811 129.856 1.00 65.65  ? 301 PHE   R CE1 1 
ATOM   3033 C CE2 . PHE   B 2 439 ? 130.766 149.362 129.205 1.00 59.98  ? 301 PHE   R CE2 1 
ATOM   3034 C CZ  . PHE   B 2 439 ? 131.846 150.212 129.242 1.00 64.77  ? 301 PHE   R CZ  1 
ATOM   3035 N N   . HIS   B 2 440 ? 133.404 143.143 131.206 1.00 59.29  ? 302 HIS   R N   1 
ATOM   3036 C CA  . HIS   B 2 440 ? 134.198 142.263 132.053 1.00 62.00  ? 302 HIS   R CA  1 
ATOM   3037 C C   . HIS   B 2 440 ? 135.638 142.146 131.575 1.00 63.06  ? 302 HIS   R C   1 
ATOM   3038 O O   . HIS   B 2 440 ? 136.516 141.791 132.368 1.00 65.75  ? 302 HIS   R O   1 
ATOM   3039 C CB  . HIS   B 2 440 ? 133.554 140.876 132.117 1.00 52.65  ? 302 HIS   R CB  1 
ATOM   3040 C CG  . HIS   B 2 440 ? 133.972 139.962 131.008 1.00 59.64  ? 302 HIS   R CG  1 
ATOM   3041 N ND1 . HIS   B 2 440 ? 133.231 139.801 129.858 1.00 64.47  ? 302 HIS   R ND1 1 
ATOM   3042 C CD2 . HIS   B 2 440 ? 135.048 139.151 130.877 1.00 65.64  ? 302 HIS   R CD2 1 
ATOM   3043 C CE1 . HIS   B 2 440 ? 133.835 138.938 129.064 1.00 59.54  ? 302 HIS   R CE1 1 
ATOM   3044 N NE2 . HIS   B 2 440 ? 134.941 138.528 129.658 1.00 61.48  ? 302 HIS   R NE2 1 
ATOM   3045 N N   . CYS   B 2 441 ? 135.901 142.433 130.300 1.00 64.52  ? 303 CYS   R N   1 
ATOM   3046 C CA  . CYS   B 2 441 ? 137.250 142.340 129.761 1.00 59.49  ? 303 CYS   R CA  1 
ATOM   3047 C C   . CYS   B 2 441 ? 138.186 143.399 130.324 1.00 64.84  ? 303 CYS   R C   1 
ATOM   3048 O O   . CYS   B 2 441 ? 139.402 143.275 130.156 1.00 74.05  ? 303 CYS   R O   1 
ATOM   3049 C CB  . CYS   B 2 441 ? 137.211 142.445 128.237 1.00 54.10  ? 303 CYS   R CB  1 
ATOM   3050 S SG  . CYS   B 2 441 ? 136.294 141.120 127.428 1.00 71.20  ? 303 CYS   R SG  1 
ATOM   3051 N N   . CYS   B 2 442 ? 137.658 144.427 130.981 1.00 57.89  ? 304 CYS   R N   1 
ATOM   3052 C CA  . CYS   B 2 442 ? 138.467 145.503 131.530 1.00 50.79  ? 304 CYS   R CA  1 
ATOM   3053 C C   . CYS   B 2 442 ? 138.684 145.384 133.031 1.00 61.75  ? 304 CYS   R C   1 
ATOM   3054 O O   . CYS   B 2 442 ? 139.271 146.288 133.628 1.00 76.22  ? 304 CYS   R O   1 
ATOM   3055 C CB  . CYS   B 2 442 ? 137.823 146.856 131.213 1.00 53.20  ? 304 CYS   R CB  1 
ATOM   3056 S SG  . CYS   B 2 442 ? 137.300 147.056 129.499 1.00 74.45  ? 304 CYS   R SG  1 
ATOM   3057 N N   . LEU   B 2 443 ? 138.233 144.297 133.658 1.00 60.01  ? 305 LEU   R N   1 
ATOM   3058 C CA  . LEU   B 2 443 ? 138.295 144.210 135.114 1.00 62.40  ? 305 LEU   R CA  1 
ATOM   3059 C C   . LEU   B 2 443 ? 139.722 144.009 135.614 1.00 58.47  ? 305 LEU   R C   1 
ATOM   3060 O O   . LEU   B 2 443 ? 140.138 144.659 136.579 1.00 58.99  ? 305 LEU   R O   1 
ATOM   3061 C CB  . LEU   B 2 443 ? 137.386 143.088 135.608 1.00 64.77  ? 305 LEU   R CB  1 
ATOM   3062 C CG  . LEU   B 2 443 ? 135.901 143.297 135.317 1.00 60.71  ? 305 LEU   R CG  1 
ATOM   3063 C CD1 . LEU   B 2 443 ? 135.102 142.102 135.781 1.00 61.46  ? 305 LEU   R CD1 1 
ATOM   3064 C CD2 . LEU   B 2 443 ? 135.399 144.569 135.978 1.00 56.33  ? 305 LEU   R CD2 1 
ATOM   3065 N N   . ASN   B 2 444 ? 140.482 143.110 134.988 1.00 63.91  ? 306 ASN   R N   1 
ATOM   3066 C CA  . ASN   B 2 444 ? 141.852 142.866 135.441 1.00 63.56  ? 306 ASN   R CA  1 
ATOM   3067 C C   . ASN   B 2 444 ? 142.737 144.101 135.338 1.00 65.01  ? 306 ASN   R C   1 
ATOM   3068 O O   . ASN   B 2 444 ? 143.406 144.435 136.333 1.00 72.26  ? 306 ASN   R O   1 
ATOM   3069 C CB  . ASN   B 2 444 ? 142.459 141.688 134.671 1.00 69.65  ? 306 ASN   R CB  1 
ATOM   3070 C CG  . ASN   B 2 444 ? 141.677 140.409 134.848 1.00 69.79  ? 306 ASN   R CG  1 
ATOM   3071 O OD1 . ASN   B 2 444 ? 141.775 139.746 135.877 1.00 73.94  ? 306 ASN   R OD1 1 
ATOM   3072 N ND2 . ASN   B 2 444 ? 140.891 140.053 133.839 1.00 65.94  ? 306 ASN   R ND2 1 
ATOM   3073 N N   . PRO   B 2 445 ? 142.815 144.809 134.202 1.00 54.85  ? 307 PRO   R N   1 
ATOM   3074 C CA  . PRO   B 2 445 ? 143.643 146.026 134.178 1.00 59.81  ? 307 PRO   R CA  1 
ATOM   3075 C C   . PRO   B 2 445 ? 143.173 147.095 135.149 1.00 65.42  ? 307 PRO   R C   1 
ATOM   3076 O O   . PRO   B 2 445 ? 144.001 147.753 135.793 1.00 65.70  ? 307 PRO   R O   1 
ATOM   3077 C CB  . PRO   B 2 445 ? 143.534 146.491 132.719 1.00 57.89  ? 307 PRO   R CB  1 
ATOM   3078 C CG  . PRO   B 2 445 ? 143.118 145.284 131.961 1.00 51.73  ? 307 PRO   R CG  1 
ATOM   3079 C CD  . PRO   B 2 445 ? 142.220 144.543 132.880 1.00 51.70  ? 307 PRO   R CD  1 
ATOM   3080 N N   . ILE   B 2 446 ? 141.859 147.280 135.283 1.00 59.40  ? 308 ILE   R N   1 
ATOM   3081 C CA  . ILE   B 2 446 ? 141.344 148.275 136.216 1.00 53.21  ? 308 ILE   R CA  1 
ATOM   3082 C C   . ILE   B 2 446 ? 141.683 147.889 137.649 1.00 55.54  ? 308 ILE   R C   1 
ATOM   3083 O O   . ILE   B 2 446 ? 142.002 148.749 138.479 1.00 64.85  ? 308 ILE   R O   1 
ATOM   3084 C CB  . ILE   B 2 446 ? 139.830 148.463 136.013 1.00 53.51  ? 308 ILE   R CB  1 
ATOM   3085 C CG1 . ILE   B 2 446 ? 139.556 149.197 134.699 1.00 55.43  ? 308 ILE   R CG1 1 
ATOM   3086 C CG2 . ILE   B 2 446 ? 139.212 149.213 137.174 1.00 60.66  ? 308 ILE   R CG2 1 
ATOM   3087 C CD1 . ILE   B 2 446 ? 138.094 149.237 134.320 1.00 59.34  ? 308 ILE   R CD1 1 
ATOM   3088 N N   . LEU   B 2 447 ? 141.635 146.594 137.962 1.00 60.94  ? 309 LEU   R N   1 
ATOM   3089 C CA  . LEU   B 2 447 ? 141.968 146.155 139.312 1.00 60.15  ? 309 LEU   R CA  1 
ATOM   3090 C C   . LEU   B 2 447 ? 143.457 146.304 139.597 1.00 64.54  ? 309 LEU   R C   1 
ATOM   3091 O O   . LEU   B 2 447 ? 143.843 146.643 140.722 1.00 70.71  ? 309 LEU   R O   1 
ATOM   3092 C CB  . LEU   B 2 447 ? 141.511 144.717 139.523 1.00 64.11  ? 309 LEU   R CB  1 
ATOM   3093 C CG  . LEU   B 2 447 ? 140.040 144.645 139.921 1.00 66.88  ? 309 LEU   R CG  1 
ATOM   3094 C CD1 . LEU   B 2 447 ? 139.507 143.253 139.723 1.00 69.82  ? 309 LEU   R CD1 1 
ATOM   3095 C CD2 . LEU   B 2 447 ? 139.867 145.084 141.363 1.00 63.92  ? 309 LEU   R CD2 1 
ATOM   3096 N N   . TYR   B 2 448 ? 144.312 146.060 138.600 1.00 66.41  ? 310 TYR   R N   1 
ATOM   3097 C CA  . TYR   B 2 448 ? 145.730 146.351 138.789 1.00 64.69  ? 310 TYR   R CA  1 
ATOM   3098 C C   . TYR   B 2 448 ? 145.962 147.838 139.005 1.00 72.36  ? 310 TYR   R C   1 
ATOM   3099 O O   . TYR   B 2 448 ? 146.794 148.230 139.830 1.00 77.78  ? 310 TYR   R O   1 
ATOM   3100 C CB  . TYR   B 2 448 ? 146.555 145.863 137.602 1.00 67.96  ? 310 TYR   R CB  1 
ATOM   3101 C CG  . TYR   B 2 448 ? 146.867 144.397 137.662 1.00 71.52  ? 310 TYR   R CG  1 
ATOM   3102 C CD1 . TYR   B 2 448 ? 147.695 143.890 138.651 1.00 73.87  ? 310 TYR   R CD1 1 
ATOM   3103 C CD2 . TYR   B 2 448 ? 146.358 143.521 136.719 1.00 70.89  ? 310 TYR   R CD2 1 
ATOM   3104 C CE1 . TYR   B 2 448 ? 147.987 142.551 138.714 1.00 72.61  ? 310 TYR   R CE1 1 
ATOM   3105 C CE2 . TYR   B 2 448 ? 146.652 142.185 136.768 1.00 74.33  ? 310 TYR   R CE2 1 
ATOM   3106 C CZ  . TYR   B 2 448 ? 147.463 141.703 137.770 1.00 72.99  ? 310 TYR   R CZ  1 
ATOM   3107 O OH  . TYR   B 2 448 ? 147.754 140.363 137.828 1.00 69.59  ? 310 TYR   R OH  1 
ATOM   3108 N N   . ALA   B 2 449 ? 145.246 148.682 138.263 1.00 63.65  ? 311 ALA   R N   1 
ATOM   3109 C CA  . ALA   B 2 449 ? 145.406 150.121 138.431 1.00 69.00  ? 311 ALA   R CA  1 
ATOM   3110 C C   . ALA   B 2 449 ? 144.989 150.561 139.829 1.00 74.50  ? 311 ALA   R C   1 
ATOM   3111 O O   . ALA   B 2 449 ? 145.722 151.290 140.508 1.00 69.94  ? 311 ALA   R O   1 
ATOM   3112 C CB  . ALA   B 2 449 ? 144.599 150.863 137.366 1.00 69.63  ? 311 ALA   R CB  1 
ATOM   3113 N N   . PHE   B 2 450 ? 143.814 150.119 140.281 1.00 81.72  ? 312 PHE   R N   1 
ATOM   3114 C CA  . PHE   B 2 450 ? 143.302 150.563 141.574 1.00 74.64  ? 312 PHE   R CA  1 
ATOM   3115 C C   . PHE   B 2 450 ? 144.122 149.997 142.726 1.00 74.86  ? 312 PHE   R C   1 
ATOM   3116 O O   . PHE   B 2 450 ? 144.534 150.736 143.628 1.00 80.25  ? 312 PHE   R O   1 
ATOM   3117 C CB  . PHE   B 2 450 ? 141.831 150.174 141.724 1.00 72.02  ? 312 PHE   R CB  1 
ATOM   3118 C CG  . PHE   B 2 450 ? 140.878 151.172 141.135 1.00 77.77  ? 312 PHE   R CG  1 
ATOM   3119 C CD1 . PHE   B 2 450 ? 140.941 152.505 141.504 1.00 80.91  ? 312 PHE   R CD1 1 
ATOM   3120 C CD2 . PHE   B 2 450 ? 139.914 150.778 140.225 1.00 79.69  ? 312 PHE   R CD2 1 
ATOM   3121 C CE1 . PHE   B 2 450 ? 140.064 153.430 140.966 1.00 81.08  ? 312 PHE   R CE1 1 
ATOM   3122 C CE2 . PHE   B 2 450 ? 139.035 151.698 139.683 1.00 80.76  ? 312 PHE   R CE2 1 
ATOM   3123 C CZ  . PHE   B 2 450 ? 139.110 153.025 140.054 1.00 80.23  ? 312 PHE   R CZ  1 
ATOM   3124 N N   . LEU   B 2 451 ? 144.371 148.690 142.718 1.00 78.21  ? 313 LEU   R N   1 
ATOM   3125 C CA  . LEU   B 2 451 ? 145.054 148.043 143.828 1.00 83.50  ? 313 LEU   R CA  1 
ATOM   3126 C C   . LEU   B 2 451 ? 146.572 148.112 143.726 1.00 84.77  ? 313 LEU   R C   1 
ATOM   3127 O O   . LEU   B 2 451 ? 147.256 147.829 144.716 1.00 84.40  ? 313 LEU   R O   1 
ATOM   3128 C CB  . LEU   B 2 451 ? 144.605 146.583 143.932 1.00 79.55  ? 313 LEU   R CB  1 
ATOM   3129 C CG  . LEU   B 2 451 ? 143.100 146.410 144.144 1.00 77.16  ? 313 LEU   R CG  1 
ATOM   3130 C CD1 . LEU   B 2 451 ? 142.671 144.995 143.826 1.00 78.98  ? 313 LEU   R CD1 1 
ATOM   3131 C CD2 . LEU   B 2 451 ? 142.712 146.779 145.565 1.00 76.78  ? 313 LEU   R CD2 1 
ATOM   3132 N N   . GLY   B 2 452 ? 147.113 148.477 142.568 1.00 85.83  ? 314 GLY   R N   1 
ATOM   3133 C CA  . GLY   B 2 452 ? 148.548 148.602 142.418 1.00 86.61  ? 314 GLY   R CA  1 
ATOM   3134 C C   . GLY   B 2 452 ? 149.040 150.016 142.638 1.00 91.29  ? 314 GLY   R C   1 
ATOM   3135 O O   . GLY   B 2 452 ? 149.772 150.562 141.807 1.00 91.07  ? 314 GLY   R O   1 
ATOM   3136 N N   . ALA   B 2 453 ? 148.642 150.621 143.752 1.00 100.13 ? 315 ALA   R N   1 
ATOM   3137 C CA  . ALA   B 2 453 ? 149.055 151.981 144.075 1.00 98.78  ? 315 ALA   R CA  1 
ATOM   3138 C C   . ALA   B 2 453 ? 150.180 151.977 145.104 1.00 98.90  ? 315 ALA   R C   1 
ATOM   3139 O O   . ALA   B 2 453 ? 151.314 151.611 144.795 1.00 99.56  ? 315 ALA   R O   1 
ATOM   3140 C CB  . ALA   B 2 453 ? 147.871 152.788 144.584 1.00 96.74  ? 315 ALA   R CB  1 
HETATM 3141 C C1  . CLR   C 3 .   ? 132.667 138.100 150.136 1.00 66.69  ? 401 CLR   R C1  1 
HETATM 3142 C C2  . CLR   C 3 .   ? 132.970 139.423 150.835 1.00 68.35  ? 401 CLR   R C2  1 
HETATM 3143 C C3  . CLR   C 3 .   ? 132.088 139.663 152.046 1.00 65.55  ? 401 CLR   R C3  1 
HETATM 3144 C C4  . CLR   C 3 .   ? 130.611 139.495 151.699 1.00 70.13  ? 401 CLR   R C4  1 
HETATM 3145 C C5  . CLR   C 3 .   ? 130.388 139.024 150.289 1.00 72.71  ? 401 CLR   R C5  1 
HETATM 3146 C C6  . CLR   C 3 .   ? 129.499 139.636 149.509 1.00 68.59  ? 401 CLR   R C6  1 
HETATM 3147 C C7  . CLR   C 3 .   ? 129.086 139.160 148.159 1.00 68.33  ? 401 CLR   R C7  1 
HETATM 3148 C C8  . CLR   C 3 .   ? 129.545 137.732 147.888 1.00 67.78  ? 401 CLR   R C8  1 
HETATM 3149 C C9  . CLR   C 3 .   ? 131.000 137.545 148.341 1.00 66.49  ? 401 CLR   R C9  1 
HETATM 3150 C C10 . CLR   C 3 .   ? 131.179 137.805 149.858 1.00 70.38  ? 401 CLR   R C10 1 
HETATM 3151 C C11 . CLR   C 3 .   ? 131.557 136.185 147.904 1.00 59.89  ? 401 CLR   R C11 1 
HETATM 3152 C C12 . CLR   C 3 .   ? 131.308 135.845 146.433 1.00 63.83  ? 401 CLR   R C12 1 
HETATM 3153 C C13 . CLR   C 3 .   ? 129.826 135.955 146.064 1.00 65.85  ? 401 CLR   R C13 1 
HETATM 3154 C C14 . CLR   C 3 .   ? 129.423 137.393 146.413 1.00 68.10  ? 401 CLR   R C14 1 
HETATM 3155 C C15 . CLR   C 3 .   ? 128.077 137.574 145.734 1.00 70.28  ? 401 CLR   R C15 1 
HETATM 3156 C C16 . CLR   C 3 .   ? 128.302 136.889 144.376 1.00 65.20  ? 401 CLR   R C16 1 
HETATM 3157 C C17 . CLR   C 3 .   ? 129.473 135.884 144.554 1.00 62.74  ? 401 CLR   R C17 1 
HETATM 3158 C C18 . CLR   C 3 .   ? 128.987 134.935 146.838 1.00 64.01  ? 401 CLR   R C18 1 
HETATM 3159 C C19 . CLR   C 3 .   ? 130.710 136.598 150.683 1.00 63.53  ? 401 CLR   R C19 1 
HETATM 3160 C C20 . CLR   C 3 .   ? 129.133 134.525 143.931 1.00 65.45  ? 401 CLR   R C20 1 
HETATM 3161 C C21 . CLR   C 3 .   ? 130.367 133.672 143.673 1.00 64.76  ? 401 CLR   R C21 1 
HETATM 3162 C C22 . CLR   C 3 .   ? 128.362 134.734 142.622 1.00 64.50  ? 401 CLR   R C22 1 
HETATM 3163 C C23 . CLR   C 3 .   ? 127.003 134.050 142.506 1.00 64.06  ? 401 CLR   R C23 1 
HETATM 3164 C C24 . CLR   C 3 .   ? 127.116 132.565 142.181 1.00 62.83  ? 401 CLR   R C24 1 
HETATM 3165 C C25 . CLR   C 3 .   ? 125.787 131.898 141.824 1.00 64.73  ? 401 CLR   R C25 1 
HETATM 3166 C C26 . CLR   C 3 .   ? 125.935 130.383 141.729 1.00 61.48  ? 401 CLR   R C26 1 
HETATM 3167 C C27 . CLR   C 3 .   ? 125.217 132.454 140.524 1.00 66.41  ? 401 CLR   R C27 1 
HETATM 3168 O O1  . CLR   C 3 .   ? 132.478 138.777 153.072 1.00 60.63  ? 401 CLR   R O1  1 
HETATM 3169 C C1  . CLR   D 3 .   ? 134.272 147.887 144.933 1.00 73.81  ? 402 CLR   R C1  1 
HETATM 3170 C C2  . CLR   D 3 .   ? 134.962 147.821 146.290 1.00 72.63  ? 402 CLR   R C2  1 
HETATM 3171 C C3  . CLR   D 3 .   ? 134.008 148.226 147.395 1.00 73.43  ? 402 CLR   R C3  1 
HETATM 3172 C C4  . CLR   D 3 .   ? 132.781 147.320 147.367 1.00 75.22  ? 402 CLR   R C4  1 
HETATM 3173 C C5  . CLR   D 3 .   ? 132.105 147.331 146.021 1.00 75.30  ? 402 CLR   R C5  1 
HETATM 3174 C C6  . CLR   D 3 .   ? 130.810 147.626 145.926 1.00 72.55  ? 402 CLR   R C6  1 
HETATM 3175 C C7  . CLR   D 3 .   ? 130.042 147.695 144.651 1.00 74.74  ? 402 CLR   R C7  1 
HETATM 3176 C C8  . CLR   D 3 .   ? 130.781 147.050 143.485 1.00 75.31  ? 402 CLR   R C8  1 
HETATM 3177 C C9  . CLR   D 3 .   ? 132.261 147.456 143.506 1.00 72.97  ? 402 CLR   R C9  1 
HETATM 3178 C C10 . CLR   D 3 .   ? 132.983 147.045 144.815 1.00 75.53  ? 402 CLR   R C10 1 
HETATM 3179 C C11 . CLR   D 3 .   ? 132.989 146.972 142.248 1.00 69.77  ? 402 CLR   R C11 1 
HETATM 3180 C C12 . CLR   D 3 .   ? 132.285 147.346 140.941 1.00 68.61  ? 402 CLR   R C12 1 
HETATM 3181 C C13 . CLR   D 3 .   ? 130.826 146.883 140.920 1.00 72.58  ? 402 CLR   R C13 1 
HETATM 3182 C C14 . CLR   D 3 .   ? 130.156 147.474 142.167 1.00 75.16  ? 402 CLR   R C14 1 
HETATM 3183 C C15 . CLR   D 3 .   ? 128.673 147.212 141.950 1.00 69.32  ? 402 CLR   R C15 1 
HETATM 3184 C C16 . CLR   D 3 .   ? 128.502 147.375 140.427 1.00 70.82  ? 402 CLR   R C16 1 
HETATM 3185 C C17 . CLR   D 3 .   ? 129.925 147.485 139.812 1.00 72.55  ? 402 CLR   R C17 1 
HETATM 3186 C C18 . CLR   D 3 .   ? 130.722 145.357 140.906 1.00 69.17  ? 402 CLR   R C18 1 
HETATM 3187 C C19 . CLR   D 3 .   ? 133.337 145.552 144.819 1.00 71.03  ? 402 CLR   R C19 1 
HETATM 3188 C C20 . CLR   D 3 .   ? 130.004 146.917 138.387 1.00 68.06  ? 402 CLR   R C20 1 
HETATM 3189 C C21 . CLR   D 3 .   ? 131.115 147.543 137.548 1.00 67.57  ? 402 CLR   R C21 1 
HETATM 3190 C C22 . CLR   D 3 .   ? 128.651 147.075 137.679 1.00 65.71  ? 402 CLR   R C22 1 
HETATM 3191 C C23 . CLR   D 3 .   ? 128.695 147.036 136.156 1.00 71.36  ? 402 CLR   R C23 1 
HETATM 3192 C C24 . CLR   D 3 .   ? 127.329 146.749 135.545 1.00 73.72  ? 402 CLR   R C24 1 
HETATM 3193 C C25 . CLR   D 3 .   ? 127.366 146.389 134.060 1.00 69.28  ? 402 CLR   R C25 1 
HETATM 3194 C C26 . CLR   D 3 .   ? 125.955 146.152 133.533 1.00 67.97  ? 402 CLR   R C26 1 
HETATM 3195 C C27 . CLR   D 3 .   ? 128.071 147.461 133.236 1.00 67.40  ? 402 CLR   R C27 1 
HETATM 3196 O O1  . CLR   D 3 .   ? 134.690 148.151 148.630 1.00 69.57  ? 402 CLR   R O1  1 
HETATM 3197 C C1  . A1D8K E 4 .   ? 130.171 137.916 115.506 1.00 76.26  ? 403 A1D8K R C1  1 
HETATM 3198 C C10 . A1D8K E 4 .   ? 122.443 141.168 120.226 1.00 79.61  ? 403 A1D8K R C10 1 
HETATM 3199 C C11 . A1D8K E 4 .   ? 121.859 139.974 120.938 1.00 78.86  ? 403 A1D8K R C11 1 
HETATM 3200 C C12 . A1D8K E 4 .   ? 122.610 139.244 121.842 1.00 71.33  ? 403 A1D8K R C12 1 
HETATM 3201 C C13 . A1D8K E 4 .   ? 122.073 138.147 122.485 1.00 67.15  ? 403 A1D8K R C13 1 
HETATM 3202 C C14 . A1D8K E 4 .   ? 120.771 137.756 122.239 1.00 73.20  ? 403 A1D8K R C14 1 
HETATM 3203 C C15 . A1D8K E 4 .   ? 120.016 138.491 121.346 1.00 76.17  ? 403 A1D8K R C15 1 
HETATM 3204 C C16 . A1D8K E 4 .   ? 120.553 139.586 120.700 1.00 76.07  ? 403 A1D8K R C16 1 
HETATM 3205 C C17 . A1D8K E 4 .   ? 120.169 136.571 122.934 1.00 71.92  ? 403 A1D8K R C17 1 
HETATM 3206 C C18 . A1D8K E 4 .   ? 118.605 135.178 121.761 1.00 70.44  ? 403 A1D8K R C18 1 
HETATM 3207 C C19 . A1D8K E 4 .   ? 117.700 135.283 120.555 1.00 75.43  ? 403 A1D8K R C19 1 
HETATM 3208 C C2  . A1D8K E 4 .   ? 129.345 137.378 116.642 1.00 75.31  ? 403 A1D8K R C2  1 
HETATM 3209 C C20 . A1D8K E 4 .   ? 116.259 135.097 120.963 1.00 70.14  ? 403 A1D8K R C20 1 
HETATM 3210 C C21 . A1D8K E 4 .   ? 115.479 134.287 119.949 1.00 71.07  ? 403 A1D8K R C21 1 
HETATM 3211 C C22 . A1D8K E 4 .   ? 114.163 133.990 120.564 1.00 71.06  ? 403 A1D8K R C22 1 
HETATM 3212 C C23 . A1D8K E 4 .   ? 112.638 135.390 121.583 1.00 75.78  ? 403 A1D8K R C23 1 
HETATM 3213 C C24 . A1D8K E 4 .   ? 118.760 134.601 118.420 1.00 77.25  ? 403 A1D8K R C24 1 
HETATM 3214 C C25 . A1D8K E 4 .   ? 118.911 133.448 117.459 1.00 75.42  ? 403 A1D8K R C25 1 
HETATM 3215 C C26 . A1D8K E 4 .   ? 117.822 132.742 116.994 1.00 76.29  ? 403 A1D8K R C26 1 
HETATM 3216 C C27 . A1D8K E 4 .   ? 118.025 131.692 116.122 1.00 79.99  ? 403 A1D8K R C27 1 
HETATM 3217 C C28 . A1D8K E 4 .   ? 119.301 131.374 115.745 1.00 79.10  ? 403 A1D8K R C28 1 
HETATM 3218 C C29 . A1D8K E 4 .   ? 120.330 132.113 116.261 1.00 76.99  ? 403 A1D8K R C29 1 
HETATM 3219 C C3  . A1D8K E 4 .   ? 128.226 138.349 116.993 1.00 72.53  ? 403 A1D8K R C3  1 
HETATM 3220 C C4  . A1D8K E 4 .   ? 127.440 138.723 115.762 1.00 70.30  ? 403 A1D8K R C4  1 
HETATM 3221 C C5  . A1D8K E 4 .   ? 128.333 139.415 114.761 1.00 70.47  ? 403 A1D8K R C5  1 
HETATM 3222 C C6  . A1D8K E 4 .   ? 129.783 139.342 115.213 1.00 76.12  ? 403 A1D8K R C6  1 
HETATM 3223 C C7  . A1D8K E 4 .   ? 125.932 139.484 117.545 1.00 77.51  ? 403 A1D8K R C7  1 
HETATM 3224 C C8  . A1D8K E 4 .   ? 125.560 140.840 118.109 1.00 77.67  ? 403 A1D8K R C8  1 
HETATM 3225 C C9  . A1D8K E 4 .   ? 124.088 140.989 118.422 1.00 73.65  ? 403 A1D8K R C9  1 
HETATM 3226 N N1  . A1D8K E 4 .   ? 126.304 139.559 116.135 1.00 76.59  ? 403 A1D8K R N1  1 
HETATM 3227 N N2  . A1D8K E 4 .   ? 123.841 140.993 119.866 1.00 75.52  ? 403 A1D8K R N2  1 
HETATM 3228 N N3  . A1D8K E 4 .   ? 118.853 136.288 122.440 1.00 67.71  ? 403 A1D8K R N3  1 
HETATM 3229 N N4  . A1D8K E 4 .   ? 113.871 134.998 121.569 1.00 69.66  ? 403 A1D8K R N4  1 
HETATM 3230 N N5  . A1D8K E 4 .   ? 111.659 134.761 120.934 1.00 77.23  ? 403 A1D8K R N5  1 
HETATM 3231 N N6  . A1D8K E 4 .   ? 112.337 136.467 122.290 1.00 78.86  ? 403 A1D8K R N6  1 
HETATM 3232 N N7  . A1D8K E 4 .   ? 117.966 134.236 119.591 1.00 81.25  ? 403 A1D8K R N7  1 
HETATM 3233 N N8  . A1D8K E 4 .   ? 120.159 133.136 117.106 1.00 76.50  ? 403 A1D8K R N8  1 
HETATM 3234 O O1  . A1D8K E 4 .   ? 119.097 134.104 122.066 1.00 73.12  ? 403 A1D8K R O1  1 
# 
