data_8ZNS
# 
_entry.id   8ZNS 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZNS         pdb_00008zns 10.2210/pdb8zns/pdb 
WWPDB D_1300048208 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-06 
2 'Structure model' 1 1 2024-11-20 
3 'Structure model' 1 2 2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Structure summary'   
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' audit_author    
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.journal_volume'          
7  2 'Structure model' '_citation.page_first'              
8  2 'Structure model' '_citation.page_last'               
9  2 'Structure model' '_citation.pdbx_database_id_DOI'    
10 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
11 2 'Structure model' '_citation.title'                   
12 2 'Structure model' '_citation.year'                    
13 3 'Structure model' '_audit_author.name'                
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZNS 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-28 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              xrayleox@cau.ac.kr 
_pdbx_contact_author.name_first         'Hyun ho' 
_pdbx_contact_author.name_last          Park 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9928-0847 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Kim, D.Y.'  1 ? 
'Park, H.H.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nucleic Acids Res.' 
_citation.journal_id_ASTM           NARHAD 
_citation.journal_id_CSD            0389 
_citation.journal_id_ISSN           1362-4962 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            52 
_citation.language                  ? 
_citation.page_first                10563 
_citation.page_last                 10574 
_citation.title                     'Structural basis of Cas3 activation in type I-C CRISPR-Cas system.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1093/nar/gkae723 
_citation.pdbx_database_id_PubMed   39180405 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kim, D.Y.'  1 ?                   
primary 'Lee, S.Y.'  2 ?                   
primary 'Ha, H.J.'   3 ?                   
primary 'Park, H.H.' 4 0000-0001-9928-0847 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'CRISPR-associated endonuclease Cas3-HD' 96315.531 1   3.1.-.- ? ? ? 
2 non-polymer syn 'FE (III) ION'                           55.845    2   ?       ? ? ? 
3 water       nat water                                    18.015    351 ?       ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MNFDYIAHARQDSSKNWHSHPLQKHLQKVAQLAKRFAGRYGSLFAEYAGLLHDLGKFQESFQKYIRNASGFEKENAHLED
VESTKLRKIPHSTAGAKYAVERLNPFFGHLLAYLIAGHHAGLADWYDKGSLKRRLQQADDELAASLSGFVESSLPEDFFP
LSDDDLMRDFFAFWEDGAKLEELHIWMRFLFSCLVDADFLDTEAFMNGYADADTAQAAGLRPKFPGLDELHRRYEQYMAQ
LSEKADKNSSLNQERHAILQQCFSAAETDRTLFSLTVPTGGGKTLASLGFALKHALKFGKKRIIYAIPFTSIIEQNANVF
RNALGDDVVLEHHSNLEVKEDKETAKTRLATENWDAPLIVTTNVQLFESLFAAKTSRCRKIHNIADSVVILDEAQQLPRD
FQKPITDMMRVLARDYGVTFVLCTATQPELGKNIDAFGRTILEGLPDVREIVADKIALSEKLRRVRIKMPPPNGETQSWQ
KIADEIAARPCVLAVVNTRKHAQKLFAALPSNGIKLHLSANMCATHCSEVIALVRRYLALYRAGSLHKPLWLVSTQLIEA
GVDLDFPCVYRAMAGLDSIAQAAGRCNREGKLPQLGEVVVFRAEEGAPSGSLKQGQDITEEMLKAGLLDDPLSPLAFAEY
FRRFNGKGDVDKHGITTLLTAEASNENPLAIKFRTAAERFHLIDNQGVALIVPFIPLAHWEKDGSPQIVEANELDDFFRR
HLDGVEVSEWQDILDKQRFPQPPDNSFGQTDQPLLPEPFESWFGLLESDPLKHKWVYRKLQRYTITVYEHELKKLPEHAV
FSRAGLLVLDKGYYKAVLGADFDDAAWLPENSVLGGSVGPKKKRKVLEHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MNFDYIAHARQDSSKNWHSHPLQKHLQKVAQLAKRFAGRYGSLFAEYAGLLHDLGKFQESFQKYIRNASGFEKENAHLED
VESTKLRKIPHSTAGAKYAVERLNPFFGHLLAYLIAGHHAGLADWYDKGSLKRRLQQADDELAASLSGFVESSLPEDFFP
LSDDDLMRDFFAFWEDGAKLEELHIWMRFLFSCLVDADFLDTEAFMNGYADADTAQAAGLRPKFPGLDELHRRYEQYMAQ
LSEKADKNSSLNQERHAILQQCFSAAETDRTLFSLTVPTGGGKTLASLGFALKHALKFGKKRIIYAIPFTSIIEQNANVF
RNALGDDVVLEHHSNLEVKEDKETAKTRLATENWDAPLIVTTNVQLFESLFAAKTSRCRKIHNIADSVVILDEAQQLPRD
FQKPITDMMRVLARDYGVTFVLCTATQPELGKNIDAFGRTILEGLPDVREIVADKIALSEKLRRVRIKMPPPNGETQSWQ
KIADEIAARPCVLAVVNTRKHAQKLFAALPSNGIKLHLSANMCATHCSEVIALVRRYLALYRAGSLHKPLWLVSTQLIEA
GVDLDFPCVYRAMAGLDSIAQAAGRCNREGKLPQLGEVVVFRAEEGAPSGSLKQGQDITEEMLKAGLLDDPLSPLAFAEY
FRRFNGKGDVDKHGITTLLTAEASNENPLAIKFRTAAERFHLIDNQGVALIVPFIPLAHWEKDGSPQIVEANELDDFFRR
HLDGVEVSEWQDILDKQRFPQPPDNSFGQTDQPLLPEPFESWFGLLESDPLKHKWVYRKLQRYTITVYEHELKKLPEHAV
FSRAGLLVLDKGYYKAVLGADFDDAAWLPENSVLGGSVGPKKKRKVLEHHHHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'FE (III) ION' FE  
3 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASN n 
1 3   PHE n 
1 4   ASP n 
1 5   TYR n 
1 6   ILE n 
1 7   ALA n 
1 8   HIS n 
1 9   ALA n 
1 10  ARG n 
1 11  GLN n 
1 12  ASP n 
1 13  SER n 
1 14  SER n 
1 15  LYS n 
1 16  ASN n 
1 17  TRP n 
1 18  HIS n 
1 19  SER n 
1 20  HIS n 
1 21  PRO n 
1 22  LEU n 
1 23  GLN n 
1 24  LYS n 
1 25  HIS n 
1 26  LEU n 
1 27  GLN n 
1 28  LYS n 
1 29  VAL n 
1 30  ALA n 
1 31  GLN n 
1 32  LEU n 
1 33  ALA n 
1 34  LYS n 
1 35  ARG n 
1 36  PHE n 
1 37  ALA n 
1 38  GLY n 
1 39  ARG n 
1 40  TYR n 
1 41  GLY n 
1 42  SER n 
1 43  LEU n 
1 44  PHE n 
1 45  ALA n 
1 46  GLU n 
1 47  TYR n 
1 48  ALA n 
1 49  GLY n 
1 50  LEU n 
1 51  LEU n 
1 52  HIS n 
1 53  ASP n 
1 54  LEU n 
1 55  GLY n 
1 56  LYS n 
1 57  PHE n 
1 58  GLN n 
1 59  GLU n 
1 60  SER n 
1 61  PHE n 
1 62  GLN n 
1 63  LYS n 
1 64  TYR n 
1 65  ILE n 
1 66  ARG n 
1 67  ASN n 
1 68  ALA n 
1 69  SER n 
1 70  GLY n 
1 71  PHE n 
1 72  GLU n 
1 73  LYS n 
1 74  GLU n 
1 75  ASN n 
1 76  ALA n 
1 77  HIS n 
1 78  LEU n 
1 79  GLU n 
1 80  ASP n 
1 81  VAL n 
1 82  GLU n 
1 83  SER n 
1 84  THR n 
1 85  LYS n 
1 86  LEU n 
1 87  ARG n 
1 88  LYS n 
1 89  ILE n 
1 90  PRO n 
1 91  HIS n 
1 92  SER n 
1 93  THR n 
1 94  ALA n 
1 95  GLY n 
1 96  ALA n 
1 97  LYS n 
1 98  TYR n 
1 99  ALA n 
1 100 VAL n 
1 101 GLU n 
1 102 ARG n 
1 103 LEU n 
1 104 ASN n 
1 105 PRO n 
1 106 PHE n 
1 107 PHE n 
1 108 GLY n 
1 109 HIS n 
1 110 LEU n 
1 111 LEU n 
1 112 ALA n 
1 113 TYR n 
1 114 LEU n 
1 115 ILE n 
1 116 ALA n 
1 117 GLY n 
1 118 HIS n 
1 119 HIS n 
1 120 ALA n 
1 121 GLY n 
1 122 LEU n 
1 123 ALA n 
1 124 ASP n 
1 125 TRP n 
1 126 TYR n 
1 127 ASP n 
1 128 LYS n 
1 129 GLY n 
1 130 SER n 
1 131 LEU n 
1 132 LYS n 
1 133 ARG n 
1 134 ARG n 
1 135 LEU n 
1 136 GLN n 
1 137 GLN n 
1 138 ALA n 
1 139 ASP n 
1 140 ASP n 
1 141 GLU n 
1 142 LEU n 
1 143 ALA n 
1 144 ALA n 
1 145 SER n 
1 146 LEU n 
1 147 SER n 
1 148 GLY n 
1 149 PHE n 
1 150 VAL n 
1 151 GLU n 
1 152 SER n 
1 153 SER n 
1 154 LEU n 
1 155 PRO n 
1 156 GLU n 
1 157 ASP n 
1 158 PHE n 
1 159 PHE n 
1 160 PRO n 
1 161 LEU n 
1 162 SER n 
1 163 ASP n 
1 164 ASP n 
1 165 ASP n 
1 166 LEU n 
1 167 MET n 
1 168 ARG n 
1 169 ASP n 
1 170 PHE n 
1 171 PHE n 
1 172 ALA n 
1 173 PHE n 
1 174 TRP n 
1 175 GLU n 
1 176 ASP n 
1 177 GLY n 
1 178 ALA n 
1 179 LYS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLU n 
1 183 LEU n 
1 184 HIS n 
1 185 ILE n 
1 186 TRP n 
1 187 MET n 
1 188 ARG n 
1 189 PHE n 
1 190 LEU n 
1 191 PHE n 
1 192 SER n 
1 193 CYS n 
1 194 LEU n 
1 195 VAL n 
1 196 ASP n 
1 197 ALA n 
1 198 ASP n 
1 199 PHE n 
1 200 LEU n 
1 201 ASP n 
1 202 THR n 
1 203 GLU n 
1 204 ALA n 
1 205 PHE n 
1 206 MET n 
1 207 ASN n 
1 208 GLY n 
1 209 TYR n 
1 210 ALA n 
1 211 ASP n 
1 212 ALA n 
1 213 ASP n 
1 214 THR n 
1 215 ALA n 
1 216 GLN n 
1 217 ALA n 
1 218 ALA n 
1 219 GLY n 
1 220 LEU n 
1 221 ARG n 
1 222 PRO n 
1 223 LYS n 
1 224 PHE n 
1 225 PRO n 
1 226 GLY n 
1 227 LEU n 
1 228 ASP n 
1 229 GLU n 
1 230 LEU n 
1 231 HIS n 
1 232 ARG n 
1 233 ARG n 
1 234 TYR n 
1 235 GLU n 
1 236 GLN n 
1 237 TYR n 
1 238 MET n 
1 239 ALA n 
1 240 GLN n 
1 241 LEU n 
1 242 SER n 
1 243 GLU n 
1 244 LYS n 
1 245 ALA n 
1 246 ASP n 
1 247 LYS n 
1 248 ASN n 
1 249 SER n 
1 250 SER n 
1 251 LEU n 
1 252 ASN n 
1 253 GLN n 
1 254 GLU n 
1 255 ARG n 
1 256 HIS n 
1 257 ALA n 
1 258 ILE n 
1 259 LEU n 
1 260 GLN n 
1 261 GLN n 
1 262 CYS n 
1 263 PHE n 
1 264 SER n 
1 265 ALA n 
1 266 ALA n 
1 267 GLU n 
1 268 THR n 
1 269 ASP n 
1 270 ARG n 
1 271 THR n 
1 272 LEU n 
1 273 PHE n 
1 274 SER n 
1 275 LEU n 
1 276 THR n 
1 277 VAL n 
1 278 PRO n 
1 279 THR n 
1 280 GLY n 
1 281 GLY n 
1 282 GLY n 
1 283 LYS n 
1 284 THR n 
1 285 LEU n 
1 286 ALA n 
1 287 SER n 
1 288 LEU n 
1 289 GLY n 
1 290 PHE n 
1 291 ALA n 
1 292 LEU n 
1 293 LYS n 
1 294 HIS n 
1 295 ALA n 
1 296 LEU n 
1 297 LYS n 
1 298 PHE n 
1 299 GLY n 
1 300 LYS n 
1 301 LYS n 
1 302 ARG n 
1 303 ILE n 
1 304 ILE n 
1 305 TYR n 
1 306 ALA n 
1 307 ILE n 
1 308 PRO n 
1 309 PHE n 
1 310 THR n 
1 311 SER n 
1 312 ILE n 
1 313 ILE n 
1 314 GLU n 
1 315 GLN n 
1 316 ASN n 
1 317 ALA n 
1 318 ASN n 
1 319 VAL n 
1 320 PHE n 
1 321 ARG n 
1 322 ASN n 
1 323 ALA n 
1 324 LEU n 
1 325 GLY n 
1 326 ASP n 
1 327 ASP n 
1 328 VAL n 
1 329 VAL n 
1 330 LEU n 
1 331 GLU n 
1 332 HIS n 
1 333 HIS n 
1 334 SER n 
1 335 ASN n 
1 336 LEU n 
1 337 GLU n 
1 338 VAL n 
1 339 LYS n 
1 340 GLU n 
1 341 ASP n 
1 342 LYS n 
1 343 GLU n 
1 344 THR n 
1 345 ALA n 
1 346 LYS n 
1 347 THR n 
1 348 ARG n 
1 349 LEU n 
1 350 ALA n 
1 351 THR n 
1 352 GLU n 
1 353 ASN n 
1 354 TRP n 
1 355 ASP n 
1 356 ALA n 
1 357 PRO n 
1 358 LEU n 
1 359 ILE n 
1 360 VAL n 
1 361 THR n 
1 362 THR n 
1 363 ASN n 
1 364 VAL n 
1 365 GLN n 
1 366 LEU n 
1 367 PHE n 
1 368 GLU n 
1 369 SER n 
1 370 LEU n 
1 371 PHE n 
1 372 ALA n 
1 373 ALA n 
1 374 LYS n 
1 375 THR n 
1 376 SER n 
1 377 ARG n 
1 378 CYS n 
1 379 ARG n 
1 380 LYS n 
1 381 ILE n 
1 382 HIS n 
1 383 ASN n 
1 384 ILE n 
1 385 ALA n 
1 386 ASP n 
1 387 SER n 
1 388 VAL n 
1 389 VAL n 
1 390 ILE n 
1 391 LEU n 
1 392 ASP n 
1 393 GLU n 
1 394 ALA n 
1 395 GLN n 
1 396 GLN n 
1 397 LEU n 
1 398 PRO n 
1 399 ARG n 
1 400 ASP n 
1 401 PHE n 
1 402 GLN n 
1 403 LYS n 
1 404 PRO n 
1 405 ILE n 
1 406 THR n 
1 407 ASP n 
1 408 MET n 
1 409 MET n 
1 410 ARG n 
1 411 VAL n 
1 412 LEU n 
1 413 ALA n 
1 414 ARG n 
1 415 ASP n 
1 416 TYR n 
1 417 GLY n 
1 418 VAL n 
1 419 THR n 
1 420 PHE n 
1 421 VAL n 
1 422 LEU n 
1 423 CYS n 
1 424 THR n 
1 425 ALA n 
1 426 THR n 
1 427 GLN n 
1 428 PRO n 
1 429 GLU n 
1 430 LEU n 
1 431 GLY n 
1 432 LYS n 
1 433 ASN n 
1 434 ILE n 
1 435 ASP n 
1 436 ALA n 
1 437 PHE n 
1 438 GLY n 
1 439 ARG n 
1 440 THR n 
1 441 ILE n 
1 442 LEU n 
1 443 GLU n 
1 444 GLY n 
1 445 LEU n 
1 446 PRO n 
1 447 ASP n 
1 448 VAL n 
1 449 ARG n 
1 450 GLU n 
1 451 ILE n 
1 452 VAL n 
1 453 ALA n 
1 454 ASP n 
1 455 LYS n 
1 456 ILE n 
1 457 ALA n 
1 458 LEU n 
1 459 SER n 
1 460 GLU n 
1 461 LYS n 
1 462 LEU n 
1 463 ARG n 
1 464 ARG n 
1 465 VAL n 
1 466 ARG n 
1 467 ILE n 
1 468 LYS n 
1 469 MET n 
1 470 PRO n 
1 471 PRO n 
1 472 PRO n 
1 473 ASN n 
1 474 GLY n 
1 475 GLU n 
1 476 THR n 
1 477 GLN n 
1 478 SER n 
1 479 TRP n 
1 480 GLN n 
1 481 LYS n 
1 482 ILE n 
1 483 ALA n 
1 484 ASP n 
1 485 GLU n 
1 486 ILE n 
1 487 ALA n 
1 488 ALA n 
1 489 ARG n 
1 490 PRO n 
1 491 CYS n 
1 492 VAL n 
1 493 LEU n 
1 494 ALA n 
1 495 VAL n 
1 496 VAL n 
1 497 ASN n 
1 498 THR n 
1 499 ARG n 
1 500 LYS n 
1 501 HIS n 
1 502 ALA n 
1 503 GLN n 
1 504 LYS n 
1 505 LEU n 
1 506 PHE n 
1 507 ALA n 
1 508 ALA n 
1 509 LEU n 
1 510 PRO n 
1 511 SER n 
1 512 ASN n 
1 513 GLY n 
1 514 ILE n 
1 515 LYS n 
1 516 LEU n 
1 517 HIS n 
1 518 LEU n 
1 519 SER n 
1 520 ALA n 
1 521 ASN n 
1 522 MET n 
1 523 CYS n 
1 524 ALA n 
1 525 THR n 
1 526 HIS n 
1 527 CYS n 
1 528 SER n 
1 529 GLU n 
1 530 VAL n 
1 531 ILE n 
1 532 ALA n 
1 533 LEU n 
1 534 VAL n 
1 535 ARG n 
1 536 ARG n 
1 537 TYR n 
1 538 LEU n 
1 539 ALA n 
1 540 LEU n 
1 541 TYR n 
1 542 ARG n 
1 543 ALA n 
1 544 GLY n 
1 545 SER n 
1 546 LEU n 
1 547 HIS n 
1 548 LYS n 
1 549 PRO n 
1 550 LEU n 
1 551 TRP n 
1 552 LEU n 
1 553 VAL n 
1 554 SER n 
1 555 THR n 
1 556 GLN n 
1 557 LEU n 
1 558 ILE n 
1 559 GLU n 
1 560 ALA n 
1 561 GLY n 
1 562 VAL n 
1 563 ASP n 
1 564 LEU n 
1 565 ASP n 
1 566 PHE n 
1 567 PRO n 
1 568 CYS n 
1 569 VAL n 
1 570 TYR n 
1 571 ARG n 
1 572 ALA n 
1 573 MET n 
1 574 ALA n 
1 575 GLY n 
1 576 LEU n 
1 577 ASP n 
1 578 SER n 
1 579 ILE n 
1 580 ALA n 
1 581 GLN n 
1 582 ALA n 
1 583 ALA n 
1 584 GLY n 
1 585 ARG n 
1 586 CYS n 
1 587 ASN n 
1 588 ARG n 
1 589 GLU n 
1 590 GLY n 
1 591 LYS n 
1 592 LEU n 
1 593 PRO n 
1 594 GLN n 
1 595 LEU n 
1 596 GLY n 
1 597 GLU n 
1 598 VAL n 
1 599 VAL n 
1 600 VAL n 
1 601 PHE n 
1 602 ARG n 
1 603 ALA n 
1 604 GLU n 
1 605 GLU n 
1 606 GLY n 
1 607 ALA n 
1 608 PRO n 
1 609 SER n 
1 610 GLY n 
1 611 SER n 
1 612 LEU n 
1 613 LYS n 
1 614 GLN n 
1 615 GLY n 
1 616 GLN n 
1 617 ASP n 
1 618 ILE n 
1 619 THR n 
1 620 GLU n 
1 621 GLU n 
1 622 MET n 
1 623 LEU n 
1 624 LYS n 
1 625 ALA n 
1 626 GLY n 
1 627 LEU n 
1 628 LEU n 
1 629 ASP n 
1 630 ASP n 
1 631 PRO n 
1 632 LEU n 
1 633 SER n 
1 634 PRO n 
1 635 LEU n 
1 636 ALA n 
1 637 PHE n 
1 638 ALA n 
1 639 GLU n 
1 640 TYR n 
1 641 PHE n 
1 642 ARG n 
1 643 ARG n 
1 644 PHE n 
1 645 ASN n 
1 646 GLY n 
1 647 LYS n 
1 648 GLY n 
1 649 ASP n 
1 650 VAL n 
1 651 ASP n 
1 652 LYS n 
1 653 HIS n 
1 654 GLY n 
1 655 ILE n 
1 656 THR n 
1 657 THR n 
1 658 LEU n 
1 659 LEU n 
1 660 THR n 
1 661 ALA n 
1 662 GLU n 
1 663 ALA n 
1 664 SER n 
1 665 ASN n 
1 666 GLU n 
1 667 ASN n 
1 668 PRO n 
1 669 LEU n 
1 670 ALA n 
1 671 ILE n 
1 672 LYS n 
1 673 PHE n 
1 674 ARG n 
1 675 THR n 
1 676 ALA n 
1 677 ALA n 
1 678 GLU n 
1 679 ARG n 
1 680 PHE n 
1 681 HIS n 
1 682 LEU n 
1 683 ILE n 
1 684 ASP n 
1 685 ASN n 
1 686 GLN n 
1 687 GLY n 
1 688 VAL n 
1 689 ALA n 
1 690 LEU n 
1 691 ILE n 
1 692 VAL n 
1 693 PRO n 
1 694 PHE n 
1 695 ILE n 
1 696 PRO n 
1 697 LEU n 
1 698 ALA n 
1 699 HIS n 
1 700 TRP n 
1 701 GLU n 
1 702 LYS n 
1 703 ASP n 
1 704 GLY n 
1 705 SER n 
1 706 PRO n 
1 707 GLN n 
1 708 ILE n 
1 709 VAL n 
1 710 GLU n 
1 711 ALA n 
1 712 ASN n 
1 713 GLU n 
1 714 LEU n 
1 715 ASP n 
1 716 ASP n 
1 717 PHE n 
1 718 PHE n 
1 719 ARG n 
1 720 ARG n 
1 721 HIS n 
1 722 LEU n 
1 723 ASP n 
1 724 GLY n 
1 725 VAL n 
1 726 GLU n 
1 727 VAL n 
1 728 SER n 
1 729 GLU n 
1 730 TRP n 
1 731 GLN n 
1 732 ASP n 
1 733 ILE n 
1 734 LEU n 
1 735 ASP n 
1 736 LYS n 
1 737 GLN n 
1 738 ARG n 
1 739 PHE n 
1 740 PRO n 
1 741 GLN n 
1 742 PRO n 
1 743 PRO n 
1 744 ASP n 
1 745 ASN n 
1 746 SER n 
1 747 PHE n 
1 748 GLY n 
1 749 GLN n 
1 750 THR n 
1 751 ASP n 
1 752 GLN n 
1 753 PRO n 
1 754 LEU n 
1 755 LEU n 
1 756 PRO n 
1 757 GLU n 
1 758 PRO n 
1 759 PHE n 
1 760 GLU n 
1 761 SER n 
1 762 TRP n 
1 763 PHE n 
1 764 GLY n 
1 765 LEU n 
1 766 LEU n 
1 767 GLU n 
1 768 SER n 
1 769 ASP n 
1 770 PRO n 
1 771 LEU n 
1 772 LYS n 
1 773 HIS n 
1 774 LYS n 
1 775 TRP n 
1 776 VAL n 
1 777 TYR n 
1 778 ARG n 
1 779 LYS n 
1 780 LEU n 
1 781 GLN n 
1 782 ARG n 
1 783 TYR n 
1 784 THR n 
1 785 ILE n 
1 786 THR n 
1 787 VAL n 
1 788 TYR n 
1 789 GLU n 
1 790 HIS n 
1 791 GLU n 
1 792 LEU n 
1 793 LYS n 
1 794 LYS n 
1 795 LEU n 
1 796 PRO n 
1 797 GLU n 
1 798 HIS n 
1 799 ALA n 
1 800 VAL n 
1 801 PHE n 
1 802 SER n 
1 803 ARG n 
1 804 ALA n 
1 805 GLY n 
1 806 LEU n 
1 807 LEU n 
1 808 VAL n 
1 809 LEU n 
1 810 ASP n 
1 811 LYS n 
1 812 GLY n 
1 813 TYR n 
1 814 TYR n 
1 815 LYS n 
1 816 ALA n 
1 817 VAL n 
1 818 LEU n 
1 819 GLY n 
1 820 ALA n 
1 821 ASP n 
1 822 PHE n 
1 823 ASP n 
1 824 ASP n 
1 825 ALA n 
1 826 ALA n 
1 827 TRP n 
1 828 LEU n 
1 829 PRO n 
1 830 GLU n 
1 831 ASN n 
1 832 SER n 
1 833 VAL n 
1 834 LEU n 
1 835 GLY n 
1 836 GLY n 
1 837 SER n 
1 838 VAL n 
1 839 GLY n 
1 840 PRO n 
1 841 LYS n 
1 842 LYS n 
1 843 LYS n 
1 844 ARG n 
1 845 LYS n 
1 846 VAL n 
1 847 LEU n 
1 848 GLU n 
1 849 HIS n 
1 850 HIS n 
1 851 HIS n 
1 852 HIS n 
1 853 HIS n 
1 854 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   854 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 NEILACOT_03977 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Neisseria lactamica ATCC 23970' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     546265 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
FE  non-polymer         . 'FE (III) ION'  ? 'Fe 3'           55.845  
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ASN 2   2   ?   ?   ?   A . n 
A 1 3   PHE 3   3   ?   ?   ?   A . n 
A 1 4   ASP 4   4   4   ASP ASP A . n 
A 1 5   TYR 5   5   5   TYR TYR A . n 
A 1 6   ILE 6   6   6   ILE ILE A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   HIS 8   8   8   HIS HIS A . n 
A 1 9   ALA 9   9   9   ALA ALA A . n 
A 1 10  ARG 10  10  10  ARG ARG A . n 
A 1 11  GLN 11  11  11  GLN GLN A . n 
A 1 12  ASP 12  12  12  ASP ASP A . n 
A 1 13  SER 13  13  13  SER SER A . n 
A 1 14  SER 14  14  14  SER SER A . n 
A 1 15  LYS 15  15  15  LYS LYS A . n 
A 1 16  ASN 16  16  16  ASN ASN A . n 
A 1 17  TRP 17  17  17  TRP TRP A . n 
A 1 18  HIS 18  18  18  HIS HIS A . n 
A 1 19  SER 19  19  19  SER SER A . n 
A 1 20  HIS 20  20  20  HIS HIS A . n 
A 1 21  PRO 21  21  21  PRO PRO A . n 
A 1 22  LEU 22  22  22  LEU LEU A . n 
A 1 23  GLN 23  23  23  GLN GLN A . n 
A 1 24  LYS 24  24  24  LYS LYS A . n 
A 1 25  HIS 25  25  25  HIS HIS A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  GLN 27  27  27  GLN GLN A . n 
A 1 28  LYS 28  28  28  LYS LYS A . n 
A 1 29  VAL 29  29  29  VAL VAL A . n 
A 1 30  ALA 30  30  30  ALA ALA A . n 
A 1 31  GLN 31  31  31  GLN GLN A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ALA 33  33  33  ALA ALA A . n 
A 1 34  LYS 34  34  34  LYS LYS A . n 
A 1 35  ARG 35  35  35  ARG ARG A . n 
A 1 36  PHE 36  36  36  PHE PHE A . n 
A 1 37  ALA 37  37  37  ALA ALA A . n 
A 1 38  GLY 38  38  38  GLY GLY A . n 
A 1 39  ARG 39  39  39  ARG ARG A . n 
A 1 40  TYR 40  40  40  TYR TYR A . n 
A 1 41  GLY 41  41  41  GLY GLY A . n 
A 1 42  SER 42  42  42  SER SER A . n 
A 1 43  LEU 43  43  43  LEU LEU A . n 
A 1 44  PHE 44  44  44  PHE PHE A . n 
A 1 45  ALA 45  45  45  ALA ALA A . n 
A 1 46  GLU 46  46  46  GLU GLU A . n 
A 1 47  TYR 47  47  47  TYR TYR A . n 
A 1 48  ALA 48  48  48  ALA ALA A . n 
A 1 49  GLY 49  49  49  GLY GLY A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  LEU 51  51  51  LEU LEU A . n 
A 1 52  HIS 52  52  52  HIS HIS A . n 
A 1 53  ASP 53  53  53  ASP ASP A . n 
A 1 54  LEU 54  54  54  LEU LEU A . n 
A 1 55  GLY 55  55  55  GLY GLY A . n 
A 1 56  LYS 56  56  56  LYS LYS A . n 
A 1 57  PHE 57  57  57  PHE PHE A . n 
A 1 58  GLN 58  58  58  GLN GLN A . n 
A 1 59  GLU 59  59  59  GLU GLU A . n 
A 1 60  SER 60  60  60  SER SER A . n 
A 1 61  PHE 61  61  61  PHE PHE A . n 
A 1 62  GLN 62  62  62  GLN GLN A . n 
A 1 63  LYS 63  63  63  LYS LYS A . n 
A 1 64  TYR 64  64  64  TYR TYR A . n 
A 1 65  ILE 65  65  65  ILE ILE A . n 
A 1 66  ARG 66  66  66  ARG ARG A . n 
A 1 67  ASN 67  67  67  ASN ASN A . n 
A 1 68  ALA 68  68  68  ALA ALA A . n 
A 1 69  SER 69  69  69  SER SER A . n 
A 1 70  GLY 70  70  70  GLY GLY A . n 
A 1 71  PHE 71  71  71  PHE PHE A . n 
A 1 72  GLU 72  72  72  GLU GLU A . n 
A 1 73  LYS 73  73  73  LYS LYS A . n 
A 1 74  GLU 74  74  74  GLU GLU A . n 
A 1 75  ASN 75  75  75  ASN ASN A . n 
A 1 76  ALA 76  76  76  ALA ALA A . n 
A 1 77  HIS 77  77  77  HIS HIS A . n 
A 1 78  LEU 78  78  78  LEU LEU A . n 
A 1 79  GLU 79  79  79  GLU GLU A . n 
A 1 80  ASP 80  80  80  ASP ASP A . n 
A 1 81  VAL 81  81  ?   ?   ?   A . n 
A 1 82  GLU 82  82  ?   ?   ?   A . n 
A 1 83  SER 83  83  ?   ?   ?   A . n 
A 1 84  THR 84  84  ?   ?   ?   A . n 
A 1 85  LYS 85  85  ?   ?   ?   A . n 
A 1 86  LEU 86  86  ?   ?   ?   A . n 
A 1 87  ARG 87  87  87  ARG ARG A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  ILE 89  89  89  ILE ILE A . n 
A 1 90  PRO 90  90  90  PRO PRO A . n 
A 1 91  HIS 91  91  91  HIS HIS A . n 
A 1 92  SER 92  92  92  SER SER A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  GLY 95  95  95  GLY GLY A . n 
A 1 96  ALA 96  96  96  ALA ALA A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  TYR 98  98  98  TYR TYR A . n 
A 1 99  ALA 99  99  99  ALA ALA A . n 
A 1 100 VAL 100 100 100 VAL VAL A . n 
A 1 101 GLU 101 101 101 GLU GLU A . n 
A 1 102 ARG 102 102 102 ARG ARG A . n 
A 1 103 LEU 103 103 103 LEU LEU A . n 
A 1 104 ASN 104 104 104 ASN ASN A . n 
A 1 105 PRO 105 105 105 PRO PRO A . n 
A 1 106 PHE 106 106 106 PHE PHE A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 GLY 108 108 108 GLY GLY A . n 
A 1 109 HIS 109 109 109 HIS HIS A . n 
A 1 110 LEU 110 110 110 LEU LEU A . n 
A 1 111 LEU 111 111 111 LEU LEU A . n 
A 1 112 ALA 112 112 112 ALA ALA A . n 
A 1 113 TYR 113 113 113 TYR TYR A . n 
A 1 114 LEU 114 114 114 LEU LEU A . n 
A 1 115 ILE 115 115 115 ILE ILE A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 GLY 117 117 117 GLY GLY A . n 
A 1 118 HIS 118 118 118 HIS HIS A . n 
A 1 119 HIS 119 119 119 HIS HIS A . n 
A 1 120 ALA 120 120 120 ALA ALA A . n 
A 1 121 GLY 121 121 121 GLY GLY A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 ALA 123 123 123 ALA ALA A . n 
A 1 124 ASP 124 124 124 ASP ASP A . n 
A 1 125 TRP 125 125 125 TRP TRP A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 ASP 127 127 127 ASP ASP A . n 
A 1 128 LYS 128 128 128 LYS LYS A . n 
A 1 129 GLY 129 129 129 GLY GLY A . n 
A 1 130 SER 130 130 130 SER SER A . n 
A 1 131 LEU 131 131 131 LEU LEU A . n 
A 1 132 LYS 132 132 132 LYS LYS A . n 
A 1 133 ARG 133 133 133 ARG ARG A . n 
A 1 134 ARG 134 134 134 ARG ARG A . n 
A 1 135 LEU 135 135 135 LEU LEU A . n 
A 1 136 GLN 136 136 136 GLN GLN A . n 
A 1 137 GLN 137 137 137 GLN GLN A . n 
A 1 138 ALA 138 138 138 ALA ALA A . n 
A 1 139 ASP 139 139 139 ASP ASP A . n 
A 1 140 ASP 140 140 140 ASP ASP A . n 
A 1 141 GLU 141 141 141 GLU GLU A . n 
A 1 142 LEU 142 142 142 LEU LEU A . n 
A 1 143 ALA 143 143 143 ALA ALA A . n 
A 1 144 ALA 144 144 144 ALA ALA A . n 
A 1 145 SER 145 145 145 SER SER A . n 
A 1 146 LEU 146 146 146 LEU LEU A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 PHE 149 149 149 PHE PHE A . n 
A 1 150 VAL 150 150 150 VAL VAL A . n 
A 1 151 GLU 151 151 151 GLU GLU A . n 
A 1 152 SER 152 152 152 SER SER A . n 
A 1 153 SER 153 153 153 SER SER A . n 
A 1 154 LEU 154 154 154 LEU LEU A . n 
A 1 155 PRO 155 155 155 PRO PRO A . n 
A 1 156 GLU 156 156 156 GLU GLU A . n 
A 1 157 ASP 157 157 157 ASP ASP A . n 
A 1 158 PHE 158 158 158 PHE PHE A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 PRO 160 160 160 PRO PRO A . n 
A 1 161 LEU 161 161 161 LEU LEU A . n 
A 1 162 SER 162 162 162 SER SER A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 ASP 164 164 164 ASP ASP A . n 
A 1 165 ASP 165 165 165 ASP ASP A . n 
A 1 166 LEU 166 166 166 LEU LEU A . n 
A 1 167 MET 167 167 167 MET MET A . n 
A 1 168 ARG 168 168 168 ARG ARG A . n 
A 1 169 ASP 169 169 169 ASP ASP A . n 
A 1 170 PHE 170 170 170 PHE PHE A . n 
A 1 171 PHE 171 171 171 PHE PHE A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 PHE 173 173 173 PHE PHE A . n 
A 1 174 TRP 174 174 174 TRP TRP A . n 
A 1 175 GLU 175 175 175 GLU GLU A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 ALA 178 178 178 ALA ALA A . n 
A 1 179 LYS 179 179 179 LYS LYS A . n 
A 1 180 LEU 180 180 180 LEU LEU A . n 
A 1 181 GLU 181 181 181 GLU GLU A . n 
A 1 182 GLU 182 182 182 GLU GLU A . n 
A 1 183 LEU 183 183 183 LEU LEU A . n 
A 1 184 HIS 184 184 184 HIS HIS A . n 
A 1 185 ILE 185 185 185 ILE ILE A . n 
A 1 186 TRP 186 186 186 TRP TRP A . n 
A 1 187 MET 187 187 187 MET MET A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 PHE 189 189 189 PHE PHE A . n 
A 1 190 LEU 190 190 190 LEU LEU A . n 
A 1 191 PHE 191 191 191 PHE PHE A . n 
A 1 192 SER 192 192 192 SER SER A . n 
A 1 193 CYS 193 193 193 CYS CYS A . n 
A 1 194 LEU 194 194 194 LEU LEU A . n 
A 1 195 VAL 195 195 195 VAL VAL A . n 
A 1 196 ASP 196 196 196 ASP ASP A . n 
A 1 197 ALA 197 197 197 ALA ALA A . n 
A 1 198 ASP 198 198 198 ASP ASP A . n 
A 1 199 PHE 199 199 199 PHE PHE A . n 
A 1 200 LEU 200 200 200 LEU LEU A . n 
A 1 201 ASP 201 201 201 ASP ASP A . n 
A 1 202 THR 202 202 202 THR THR A . n 
A 1 203 GLU 203 203 203 GLU GLU A . n 
A 1 204 ALA 204 204 204 ALA ALA A . n 
A 1 205 PHE 205 205 205 PHE PHE A . n 
A 1 206 MET 206 206 206 MET MET A . n 
A 1 207 ASN 207 207 207 ASN ASN A . n 
A 1 208 GLY 208 208 208 GLY GLY A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ASP 211 211 211 ASP ASP A . n 
A 1 212 ALA 212 212 212 ALA ALA A . n 
A 1 213 ASP 213 213 213 ASP ASP A . n 
A 1 214 THR 214 214 214 THR THR A . n 
A 1 215 ALA 215 215 215 ALA ALA A . n 
A 1 216 GLN 216 216 216 GLN GLN A . n 
A 1 217 ALA 217 217 217 ALA ALA A . n 
A 1 218 ALA 218 218 218 ALA ALA A . n 
A 1 219 GLY 219 219 219 GLY GLY A . n 
A 1 220 LEU 220 220 ?   ?   ?   A . n 
A 1 221 ARG 221 221 ?   ?   ?   A . n 
A 1 222 PRO 222 222 ?   ?   ?   A . n 
A 1 223 LYS 223 223 ?   ?   ?   A . n 
A 1 224 PHE 224 224 224 PHE PHE A . n 
A 1 225 PRO 225 225 225 PRO PRO A . n 
A 1 226 GLY 226 226 226 GLY GLY A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASP 228 228 228 ASP ASP A . n 
A 1 229 GLU 229 229 229 GLU GLU A . n 
A 1 230 LEU 230 230 230 LEU LEU A . n 
A 1 231 HIS 231 231 231 HIS HIS A . n 
A 1 232 ARG 232 232 232 ARG ARG A . n 
A 1 233 ARG 233 233 233 ARG ARG A . n 
A 1 234 TYR 234 234 234 TYR TYR A . n 
A 1 235 GLU 235 235 235 GLU GLU A . n 
A 1 236 GLN 236 236 236 GLN GLN A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 MET 238 238 238 MET MET A . n 
A 1 239 ALA 239 239 239 ALA ALA A . n 
A 1 240 GLN 240 240 240 GLN GLN A . n 
A 1 241 LEU 241 241 241 LEU LEU A . n 
A 1 242 SER 242 242 242 SER SER A . n 
A 1 243 GLU 243 243 243 GLU GLU A . n 
A 1 244 LYS 244 244 244 LYS LYS A . n 
A 1 245 ALA 245 245 245 ALA ALA A . n 
A 1 246 ASP 246 246 246 ASP ASP A . n 
A 1 247 LYS 247 247 247 LYS LYS A . n 
A 1 248 ASN 248 248 248 ASN ASN A . n 
A 1 249 SER 249 249 249 SER SER A . n 
A 1 250 SER 250 250 250 SER SER A . n 
A 1 251 LEU 251 251 251 LEU LEU A . n 
A 1 252 ASN 252 252 252 ASN ASN A . n 
A 1 253 GLN 253 253 253 GLN GLN A . n 
A 1 254 GLU 254 254 254 GLU GLU A . n 
A 1 255 ARG 255 255 255 ARG ARG A . n 
A 1 256 HIS 256 256 256 HIS HIS A . n 
A 1 257 ALA 257 257 257 ALA ALA A . n 
A 1 258 ILE 258 258 258 ILE ILE A . n 
A 1 259 LEU 259 259 259 LEU LEU A . n 
A 1 260 GLN 260 260 260 GLN GLN A . n 
A 1 261 GLN 261 261 261 GLN GLN A . n 
A 1 262 CYS 262 262 262 CYS CYS A . n 
A 1 263 PHE 263 263 263 PHE PHE A . n 
A 1 264 SER 264 264 264 SER SER A . n 
A 1 265 ALA 265 265 265 ALA ALA A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 GLU 267 267 267 GLU GLU A . n 
A 1 268 THR 268 268 268 THR THR A . n 
A 1 269 ASP 269 269 269 ASP ASP A . n 
A 1 270 ARG 270 270 270 ARG ARG A . n 
A 1 271 THR 271 271 271 THR THR A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 PHE 273 273 273 PHE PHE A . n 
A 1 274 SER 274 274 274 SER SER A . n 
A 1 275 LEU 275 275 275 LEU LEU A . n 
A 1 276 THR 276 276 276 THR THR A . n 
A 1 277 VAL 277 277 277 VAL VAL A . n 
A 1 278 PRO 278 278 278 PRO PRO A . n 
A 1 279 THR 279 279 279 THR THR A . n 
A 1 280 GLY 280 280 280 GLY GLY A . n 
A 1 281 GLY 281 281 281 GLY GLY A . n 
A 1 282 GLY 282 282 282 GLY GLY A . n 
A 1 283 LYS 283 283 283 LYS LYS A . n 
A 1 284 THR 284 284 284 THR THR A . n 
A 1 285 LEU 285 285 285 LEU LEU A . n 
A 1 286 ALA 286 286 286 ALA ALA A . n 
A 1 287 SER 287 287 287 SER SER A . n 
A 1 288 LEU 288 288 288 LEU LEU A . n 
A 1 289 GLY 289 289 289 GLY GLY A . n 
A 1 290 PHE 290 290 290 PHE PHE A . n 
A 1 291 ALA 291 291 291 ALA ALA A . n 
A 1 292 LEU 292 292 292 LEU LEU A . n 
A 1 293 LYS 293 293 293 LYS LYS A . n 
A 1 294 HIS 294 294 294 HIS HIS A . n 
A 1 295 ALA 295 295 295 ALA ALA A . n 
A 1 296 LEU 296 296 296 LEU LEU A . n 
A 1 297 LYS 297 297 297 LYS LYS A . n 
A 1 298 PHE 298 298 298 PHE PHE A . n 
A 1 299 GLY 299 299 299 GLY GLY A . n 
A 1 300 LYS 300 300 300 LYS LYS A . n 
A 1 301 LYS 301 301 301 LYS LYS A . n 
A 1 302 ARG 302 302 302 ARG ARG A . n 
A 1 303 ILE 303 303 303 ILE ILE A . n 
A 1 304 ILE 304 304 304 ILE ILE A . n 
A 1 305 TYR 305 305 305 TYR TYR A . n 
A 1 306 ALA 306 306 306 ALA ALA A . n 
A 1 307 ILE 307 307 307 ILE ILE A . n 
A 1 308 PRO 308 308 308 PRO PRO A . n 
A 1 309 PHE 309 309 309 PHE PHE A . n 
A 1 310 THR 310 310 310 THR THR A . n 
A 1 311 SER 311 311 311 SER SER A . n 
A 1 312 ILE 312 312 312 ILE ILE A . n 
A 1 313 ILE 313 313 313 ILE ILE A . n 
A 1 314 GLU 314 314 314 GLU GLU A . n 
A 1 315 GLN 315 315 315 GLN GLN A . n 
A 1 316 ASN 316 316 316 ASN ASN A . n 
A 1 317 ALA 317 317 317 ALA ALA A . n 
A 1 318 ASN 318 318 318 ASN ASN A . n 
A 1 319 VAL 319 319 319 VAL VAL A . n 
A 1 320 PHE 320 320 320 PHE PHE A . n 
A 1 321 ARG 321 321 321 ARG ARG A . n 
A 1 322 ASN 322 322 322 ASN ASN A . n 
A 1 323 ALA 323 323 323 ALA ALA A . n 
A 1 324 LEU 324 324 324 LEU LEU A . n 
A 1 325 GLY 325 325 325 GLY GLY A . n 
A 1 326 ASP 326 326 326 ASP ASP A . n 
A 1 327 ASP 327 327 327 ASP ASP A . n 
A 1 328 VAL 328 328 328 VAL VAL A . n 
A 1 329 VAL 329 329 329 VAL VAL A . n 
A 1 330 LEU 330 330 330 LEU LEU A . n 
A 1 331 GLU 331 331 331 GLU GLU A . n 
A 1 332 HIS 332 332 332 HIS HIS A . n 
A 1 333 HIS 333 333 333 HIS HIS A . n 
A 1 334 SER 334 334 334 SER SER A . n 
A 1 335 ASN 335 335 335 ASN ASN A . n 
A 1 336 LEU 336 336 336 LEU LEU A . n 
A 1 337 GLU 337 337 337 GLU GLU A . n 
A 1 338 VAL 338 338 338 VAL VAL A . n 
A 1 339 LYS 339 339 339 LYS LYS A . n 
A 1 340 GLU 340 340 340 GLU GLU A . n 
A 1 341 ASP 341 341 341 ASP ASP A . n 
A 1 342 LYS 342 342 342 LYS LYS A . n 
A 1 343 GLU 343 343 343 GLU GLU A . n 
A 1 344 THR 344 344 344 THR THR A . n 
A 1 345 ALA 345 345 345 ALA ALA A . n 
A 1 346 LYS 346 346 346 LYS LYS A . n 
A 1 347 THR 347 347 347 THR THR A . n 
A 1 348 ARG 348 348 348 ARG ARG A . n 
A 1 349 LEU 349 349 349 LEU LEU A . n 
A 1 350 ALA 350 350 350 ALA ALA A . n 
A 1 351 THR 351 351 351 THR THR A . n 
A 1 352 GLU 352 352 352 GLU GLU A . n 
A 1 353 ASN 353 353 353 ASN ASN A . n 
A 1 354 TRP 354 354 354 TRP TRP A . n 
A 1 355 ASP 355 355 355 ASP ASP A . n 
A 1 356 ALA 356 356 356 ALA ALA A . n 
A 1 357 PRO 357 357 357 PRO PRO A . n 
A 1 358 LEU 358 358 358 LEU LEU A . n 
A 1 359 ILE 359 359 359 ILE ILE A . n 
A 1 360 VAL 360 360 360 VAL VAL A . n 
A 1 361 THR 361 361 361 THR THR A . n 
A 1 362 THR 362 362 362 THR THR A . n 
A 1 363 ASN 363 363 363 ASN ASN A . n 
A 1 364 VAL 364 364 364 VAL VAL A . n 
A 1 365 GLN 365 365 365 GLN GLN A . n 
A 1 366 LEU 366 366 366 LEU LEU A . n 
A 1 367 PHE 367 367 367 PHE PHE A . n 
A 1 368 GLU 368 368 368 GLU GLU A . n 
A 1 369 SER 369 369 369 SER SER A . n 
A 1 370 LEU 370 370 370 LEU LEU A . n 
A 1 371 PHE 371 371 371 PHE PHE A . n 
A 1 372 ALA 372 372 372 ALA ALA A . n 
A 1 373 ALA 373 373 373 ALA ALA A . n 
A 1 374 LYS 374 374 374 LYS LYS A . n 
A 1 375 THR 375 375 375 THR THR A . n 
A 1 376 SER 376 376 376 SER SER A . n 
A 1 377 ARG 377 377 377 ARG ARG A . n 
A 1 378 CYS 378 378 378 CYS CYS A . n 
A 1 379 ARG 379 379 379 ARG ARG A . n 
A 1 380 LYS 380 380 380 LYS LYS A . n 
A 1 381 ILE 381 381 381 ILE ILE A . n 
A 1 382 HIS 382 382 382 HIS HIS A . n 
A 1 383 ASN 383 383 383 ASN ASN A . n 
A 1 384 ILE 384 384 384 ILE ILE A . n 
A 1 385 ALA 385 385 385 ALA ALA A . n 
A 1 386 ASP 386 386 386 ASP ASP A . n 
A 1 387 SER 387 387 387 SER SER A . n 
A 1 388 VAL 388 388 388 VAL VAL A . n 
A 1 389 VAL 389 389 389 VAL VAL A . n 
A 1 390 ILE 390 390 390 ILE ILE A . n 
A 1 391 LEU 391 391 391 LEU LEU A . n 
A 1 392 ASP 392 392 392 ASP ASP A . n 
A 1 393 GLU 393 393 393 GLU GLU A . n 
A 1 394 ALA 394 394 394 ALA ALA A . n 
A 1 395 GLN 395 395 395 GLN GLN A . n 
A 1 396 GLN 396 396 396 GLN GLN A . n 
A 1 397 LEU 397 397 397 LEU LEU A . n 
A 1 398 PRO 398 398 398 PRO PRO A . n 
A 1 399 ARG 399 399 399 ARG ARG A . n 
A 1 400 ASP 400 400 400 ASP ASP A . n 
A 1 401 PHE 401 401 401 PHE PHE A . n 
A 1 402 GLN 402 402 402 GLN GLN A . n 
A 1 403 LYS 403 403 403 LYS LYS A . n 
A 1 404 PRO 404 404 404 PRO PRO A . n 
A 1 405 ILE 405 405 405 ILE ILE A . n 
A 1 406 THR 406 406 406 THR THR A . n 
A 1 407 ASP 407 407 407 ASP ASP A . n 
A 1 408 MET 408 408 408 MET MET A . n 
A 1 409 MET 409 409 409 MET MET A . n 
A 1 410 ARG 410 410 410 ARG ARG A . n 
A 1 411 VAL 411 411 411 VAL VAL A . n 
A 1 412 LEU 412 412 412 LEU LEU A . n 
A 1 413 ALA 413 413 413 ALA ALA A . n 
A 1 414 ARG 414 414 414 ARG ARG A . n 
A 1 415 ASP 415 415 415 ASP ASP A . n 
A 1 416 TYR 416 416 416 TYR TYR A . n 
A 1 417 GLY 417 417 417 GLY GLY A . n 
A 1 418 VAL 418 418 418 VAL VAL A . n 
A 1 419 THR 419 419 419 THR THR A . n 
A 1 420 PHE 420 420 420 PHE PHE A . n 
A 1 421 VAL 421 421 421 VAL VAL A . n 
A 1 422 LEU 422 422 422 LEU LEU A . n 
A 1 423 CYS 423 423 423 CYS CYS A . n 
A 1 424 THR 424 424 424 THR THR A . n 
A 1 425 ALA 425 425 425 ALA ALA A . n 
A 1 426 THR 426 426 426 THR THR A . n 
A 1 427 GLN 427 427 427 GLN GLN A . n 
A 1 428 PRO 428 428 428 PRO PRO A . n 
A 1 429 GLU 429 429 429 GLU GLU A . n 
A 1 430 LEU 430 430 430 LEU LEU A . n 
A 1 431 GLY 431 431 ?   ?   ?   A . n 
A 1 432 LYS 432 432 ?   ?   ?   A . n 
A 1 433 ASN 433 433 ?   ?   ?   A . n 
A 1 434 ILE 434 434 434 ILE ILE A . n 
A 1 435 ASP 435 435 435 ASP ASP A . n 
A 1 436 ALA 436 436 436 ALA ALA A . n 
A 1 437 PHE 437 437 437 PHE PHE A . n 
A 1 438 GLY 438 438 438 GLY GLY A . n 
A 1 439 ARG 439 439 439 ARG ARG A . n 
A 1 440 THR 440 440 440 THR THR A . n 
A 1 441 ILE 441 441 441 ILE ILE A . n 
A 1 442 LEU 442 442 442 LEU LEU A . n 
A 1 443 GLU 443 443 443 GLU GLU A . n 
A 1 444 GLY 444 444 444 GLY GLY A . n 
A 1 445 LEU 445 445 445 LEU LEU A . n 
A 1 446 PRO 446 446 446 PRO PRO A . n 
A 1 447 ASP 447 447 447 ASP ASP A . n 
A 1 448 VAL 448 448 448 VAL VAL A . n 
A 1 449 ARG 449 449 449 ARG ARG A . n 
A 1 450 GLU 450 450 450 GLU GLU A . n 
A 1 451 ILE 451 451 451 ILE ILE A . n 
A 1 452 VAL 452 452 452 VAL VAL A . n 
A 1 453 ALA 453 453 453 ALA ALA A . n 
A 1 454 ASP 454 454 454 ASP ASP A . n 
A 1 455 LYS 455 455 455 LYS LYS A . n 
A 1 456 ILE 456 456 456 ILE ALA A . n 
A 1 457 ALA 457 457 ?   ?   ?   A . n 
A 1 458 LEU 458 458 ?   ?   ?   A . n 
A 1 459 SER 459 459 ?   ?   ?   A . n 
A 1 460 GLU 460 460 ?   ?   ?   A . n 
A 1 461 LYS 461 461 461 LYS ALA A . n 
A 1 462 LEU 462 462 462 LEU LEU A . n 
A 1 463 ARG 463 463 463 ARG ARG A . n 
A 1 464 ARG 464 464 464 ARG ARG A . n 
A 1 465 VAL 465 465 465 VAL VAL A . n 
A 1 466 ARG 466 466 466 ARG ARG A . n 
A 1 467 ILE 467 467 467 ILE ILE A . n 
A 1 468 LYS 468 468 468 LYS LYS A . n 
A 1 469 MET 469 469 469 MET MET A . n 
A 1 470 PRO 470 470 470 PRO PRO A . n 
A 1 471 PRO 471 471 471 PRO PRO A . n 
A 1 472 PRO 472 472 472 PRO PRO A . n 
A 1 473 ASN 473 473 473 ASN ASN A . n 
A 1 474 GLY 474 474 474 GLY GLY A . n 
A 1 475 GLU 475 475 475 GLU GLU A . n 
A 1 476 THR 476 476 476 THR THR A . n 
A 1 477 GLN 477 477 477 GLN GLN A . n 
A 1 478 SER 478 478 478 SER SER A . n 
A 1 479 TRP 479 479 479 TRP TRP A . n 
A 1 480 GLN 480 480 480 GLN GLN A . n 
A 1 481 LYS 481 481 481 LYS LYS A . n 
A 1 482 ILE 482 482 482 ILE ILE A . n 
A 1 483 ALA 483 483 483 ALA ALA A . n 
A 1 484 ASP 484 484 484 ASP ASP A . n 
A 1 485 GLU 485 485 485 GLU GLU A . n 
A 1 486 ILE 486 486 486 ILE ILE A . n 
A 1 487 ALA 487 487 487 ALA ALA A . n 
A 1 488 ALA 488 488 488 ALA ALA A . n 
A 1 489 ARG 489 489 489 ARG ARG A . n 
A 1 490 PRO 490 490 490 PRO PRO A . n 
A 1 491 CYS 491 491 491 CYS CYS A . n 
A 1 492 VAL 492 492 492 VAL VAL A . n 
A 1 493 LEU 493 493 493 LEU LEU A . n 
A 1 494 ALA 494 494 494 ALA ALA A . n 
A 1 495 VAL 495 495 495 VAL VAL A . n 
A 1 496 VAL 496 496 496 VAL VAL A . n 
A 1 497 ASN 497 497 497 ASN ASN A . n 
A 1 498 THR 498 498 498 THR THR A . n 
A 1 499 ARG 499 499 499 ARG ARG A . n 
A 1 500 LYS 500 500 500 LYS LYS A . n 
A 1 501 HIS 501 501 501 HIS HIS A . n 
A 1 502 ALA 502 502 502 ALA ALA A . n 
A 1 503 GLN 503 503 503 GLN GLN A . n 
A 1 504 LYS 504 504 504 LYS LYS A . n 
A 1 505 LEU 505 505 505 LEU LEU A . n 
A 1 506 PHE 506 506 506 PHE PHE A . n 
A 1 507 ALA 507 507 507 ALA ALA A . n 
A 1 508 ALA 508 508 508 ALA ALA A . n 
A 1 509 LEU 509 509 509 LEU LEU A . n 
A 1 510 PRO 510 510 510 PRO PRO A . n 
A 1 511 SER 511 511 511 SER SER A . n 
A 1 512 ASN 512 512 512 ASN ASN A . n 
A 1 513 GLY 513 513 513 GLY GLY A . n 
A 1 514 ILE 514 514 514 ILE ILE A . n 
A 1 515 LYS 515 515 515 LYS LYS A . n 
A 1 516 LEU 516 516 516 LEU LEU A . n 
A 1 517 HIS 517 517 517 HIS HIS A . n 
A 1 518 LEU 518 518 518 LEU LEU A . n 
A 1 519 SER 519 519 519 SER SER A . n 
A 1 520 ALA 520 520 520 ALA ALA A . n 
A 1 521 ASN 521 521 521 ASN ASN A . n 
A 1 522 MET 522 522 522 MET MET A . n 
A 1 523 CYS 523 523 523 CYS CYS A . n 
A 1 524 ALA 524 524 524 ALA ALA A . n 
A 1 525 THR 525 525 525 THR THR A . n 
A 1 526 HIS 526 526 526 HIS HIS A . n 
A 1 527 CYS 527 527 527 CYS CYS A . n 
A 1 528 SER 528 528 528 SER SER A . n 
A 1 529 GLU 529 529 529 GLU GLU A . n 
A 1 530 VAL 530 530 530 VAL VAL A . n 
A 1 531 ILE 531 531 531 ILE ILE A . n 
A 1 532 ALA 532 532 532 ALA ALA A . n 
A 1 533 LEU 533 533 533 LEU LEU A . n 
A 1 534 VAL 534 534 534 VAL VAL A . n 
A 1 535 ARG 535 535 535 ARG ARG A . n 
A 1 536 ARG 536 536 536 ARG ARG A . n 
A 1 537 TYR 537 537 537 TYR TYR A . n 
A 1 538 LEU 538 538 538 LEU LEU A . n 
A 1 539 ALA 539 539 539 ALA ALA A . n 
A 1 540 LEU 540 540 540 LEU LEU A . n 
A 1 541 TYR 541 541 541 TYR TYR A . n 
A 1 542 ARG 542 542 542 ARG ARG A . n 
A 1 543 ALA 543 543 543 ALA ALA A . n 
A 1 544 GLY 544 544 544 GLY GLY A . n 
A 1 545 SER 545 545 545 SER SER A . n 
A 1 546 LEU 546 546 546 LEU LEU A . n 
A 1 547 HIS 547 547 547 HIS HIS A . n 
A 1 548 LYS 548 548 548 LYS LYS A . n 
A 1 549 PRO 549 549 549 PRO PRO A . n 
A 1 550 LEU 550 550 550 LEU LEU A . n 
A 1 551 TRP 551 551 551 TRP TRP A . n 
A 1 552 LEU 552 552 552 LEU LEU A . n 
A 1 553 VAL 553 553 553 VAL VAL A . n 
A 1 554 SER 554 554 554 SER SER A . n 
A 1 555 THR 555 555 555 THR THR A . n 
A 1 556 GLN 556 556 556 GLN GLN A . n 
A 1 557 LEU 557 557 557 LEU LEU A . n 
A 1 558 ILE 558 558 558 ILE ILE A . n 
A 1 559 GLU 559 559 559 GLU GLU A . n 
A 1 560 ALA 560 560 560 ALA ALA A . n 
A 1 561 GLY 561 561 561 GLY GLY A . n 
A 1 562 VAL 562 562 562 VAL VAL A . n 
A 1 563 ASP 563 563 563 ASP ASP A . n 
A 1 564 LEU 564 564 564 LEU LEU A . n 
A 1 565 ASP 565 565 565 ASP ASP A . n 
A 1 566 PHE 566 566 566 PHE PHE A . n 
A 1 567 PRO 567 567 567 PRO PRO A . n 
A 1 568 CYS 568 568 568 CYS CYS A . n 
A 1 569 VAL 569 569 569 VAL VAL A . n 
A 1 570 TYR 570 570 570 TYR TYR A . n 
A 1 571 ARG 571 571 571 ARG ARG A . n 
A 1 572 ALA 572 572 572 ALA ALA A . n 
A 1 573 MET 573 573 573 MET MET A . n 
A 1 574 ALA 574 574 574 ALA ALA A . n 
A 1 575 GLY 575 575 575 GLY GLY A . n 
A 1 576 LEU 576 576 576 LEU LEU A . n 
A 1 577 ASP 577 577 577 ASP ASP A . n 
A 1 578 SER 578 578 578 SER SER A . n 
A 1 579 ILE 579 579 579 ILE ILE A . n 
A 1 580 ALA 580 580 580 ALA ALA A . n 
A 1 581 GLN 581 581 581 GLN GLN A . n 
A 1 582 ALA 582 582 582 ALA ALA A . n 
A 1 583 ALA 583 583 583 ALA ALA A . n 
A 1 584 GLY 584 584 584 GLY GLY A . n 
A 1 585 ARG 585 585 585 ARG ARG A . n 
A 1 586 CYS 586 586 586 CYS CYS A . n 
A 1 587 ASN 587 587 587 ASN ASN A . n 
A 1 588 ARG 588 588 588 ARG ARG A . n 
A 1 589 GLU 589 589 589 GLU GLU A . n 
A 1 590 GLY 590 590 590 GLY GLY A . n 
A 1 591 LYS 591 591 591 LYS LYS A . n 
A 1 592 LEU 592 592 592 LEU LEU A . n 
A 1 593 PRO 593 593 593 PRO PRO A . n 
A 1 594 GLN 594 594 594 GLN GLN A . n 
A 1 595 LEU 595 595 595 LEU LEU A . n 
A 1 596 GLY 596 596 596 GLY GLY A . n 
A 1 597 GLU 597 597 597 GLU GLU A . n 
A 1 598 VAL 598 598 598 VAL VAL A . n 
A 1 599 VAL 599 599 599 VAL VAL A . n 
A 1 600 VAL 600 600 600 VAL VAL A . n 
A 1 601 PHE 601 601 601 PHE PHE A . n 
A 1 602 ARG 602 602 602 ARG ARG A . n 
A 1 603 ALA 603 603 603 ALA ALA A . n 
A 1 604 GLU 604 604 604 GLU GLU A . n 
A 1 605 GLU 605 605 605 GLU GLU A . n 
A 1 606 GLY 606 606 606 GLY GLY A . n 
A 1 607 ALA 607 607 607 ALA ALA A . n 
A 1 608 PRO 608 608 608 PRO PRO A . n 
A 1 609 SER 609 609 609 SER SER A . n 
A 1 610 GLY 610 610 610 GLY GLY A . n 
A 1 611 SER 611 611 611 SER SER A . n 
A 1 612 LEU 612 612 612 LEU LEU A . n 
A 1 613 LYS 613 613 613 LYS LYS A . n 
A 1 614 GLN 614 614 614 GLN GLN A . n 
A 1 615 GLY 615 615 615 GLY GLY A . n 
A 1 616 GLN 616 616 616 GLN GLN A . n 
A 1 617 ASP 617 617 617 ASP ASP A . n 
A 1 618 ILE 618 618 618 ILE ILE A . n 
A 1 619 THR 619 619 619 THR THR A . n 
A 1 620 GLU 620 620 620 GLU GLU A . n 
A 1 621 GLU 621 621 621 GLU GLU A . n 
A 1 622 MET 622 622 622 MET MET A . n 
A 1 623 LEU 623 623 623 LEU LEU A . n 
A 1 624 LYS 624 624 624 LYS LYS A . n 
A 1 625 ALA 625 625 625 ALA ALA A . n 
A 1 626 GLY 626 626 626 GLY GLY A . n 
A 1 627 LEU 627 627 627 LEU LEU A . n 
A 1 628 LEU 628 628 628 LEU LEU A . n 
A 1 629 ASP 629 629 629 ASP ASP A . n 
A 1 630 ASP 630 630 630 ASP ASP A . n 
A 1 631 PRO 631 631 631 PRO PRO A . n 
A 1 632 LEU 632 632 632 LEU LEU A . n 
A 1 633 SER 633 633 633 SER SER A . n 
A 1 634 PRO 634 634 634 PRO PRO A . n 
A 1 635 LEU 635 635 635 LEU LEU A . n 
A 1 636 ALA 636 636 636 ALA ALA A . n 
A 1 637 PHE 637 637 637 PHE PHE A . n 
A 1 638 ALA 638 638 638 ALA ALA A . n 
A 1 639 GLU 639 639 639 GLU GLU A . n 
A 1 640 TYR 640 640 640 TYR TYR A . n 
A 1 641 PHE 641 641 641 PHE PHE A . n 
A 1 642 ARG 642 642 642 ARG ARG A . n 
A 1 643 ARG 643 643 643 ARG ARG A . n 
A 1 644 PHE 644 644 644 PHE PHE A . n 
A 1 645 ASN 645 645 645 ASN ASN A . n 
A 1 646 GLY 646 646 646 GLY GLY A . n 
A 1 647 LYS 647 647 647 LYS LYS A . n 
A 1 648 GLY 648 648 648 GLY GLY A . n 
A 1 649 ASP 649 649 649 ASP ASP A . n 
A 1 650 VAL 650 650 650 VAL VAL A . n 
A 1 651 ASP 651 651 651 ASP ASP A . n 
A 1 652 LYS 652 652 652 LYS LYS A . n 
A 1 653 HIS 653 653 653 HIS HIS A . n 
A 1 654 GLY 654 654 654 GLY GLY A . n 
A 1 655 ILE 655 655 655 ILE ILE A . n 
A 1 656 THR 656 656 656 THR THR A . n 
A 1 657 THR 657 657 657 THR THR A . n 
A 1 658 LEU 658 658 658 LEU LEU A . n 
A 1 659 LEU 659 659 659 LEU LEU A . n 
A 1 660 THR 660 660 660 THR THR A . n 
A 1 661 ALA 661 661 661 ALA ALA A . n 
A 1 662 GLU 662 662 662 GLU GLU A . n 
A 1 663 ALA 663 663 663 ALA ALA A . n 
A 1 664 SER 664 664 664 SER SER A . n 
A 1 665 ASN 665 665 665 ASN ASN A . n 
A 1 666 GLU 666 666 666 GLU GLU A . n 
A 1 667 ASN 667 667 667 ASN ASN A . n 
A 1 668 PRO 668 668 668 PRO PRO A . n 
A 1 669 LEU 669 669 669 LEU LEU A . n 
A 1 670 ALA 670 670 670 ALA ALA A . n 
A 1 671 ILE 671 671 671 ILE ILE A . n 
A 1 672 LYS 672 672 672 LYS LYS A . n 
A 1 673 PHE 673 673 673 PHE PHE A . n 
A 1 674 ARG 674 674 674 ARG ARG A . n 
A 1 675 THR 675 675 675 THR THR A . n 
A 1 676 ALA 676 676 676 ALA ALA A . n 
A 1 677 ALA 677 677 677 ALA ALA A . n 
A 1 678 GLU 678 678 678 GLU GLU A . n 
A 1 679 ARG 679 679 679 ARG ARG A . n 
A 1 680 PHE 680 680 680 PHE PHE A . n 
A 1 681 HIS 681 681 681 HIS HIS A . n 
A 1 682 LEU 682 682 682 LEU LEU A . n 
A 1 683 ILE 683 683 683 ILE ILE A . n 
A 1 684 ASP 684 684 684 ASP ASP A . n 
A 1 685 ASN 685 685 685 ASN ASN A . n 
A 1 686 GLN 686 686 686 GLN GLN A . n 
A 1 687 GLY 687 687 687 GLY GLY A . n 
A 1 688 VAL 688 688 688 VAL VAL A . n 
A 1 689 ALA 689 689 689 ALA ALA A . n 
A 1 690 LEU 690 690 690 LEU LEU A . n 
A 1 691 ILE 691 691 691 ILE ILE A . n 
A 1 692 VAL 692 692 692 VAL VAL A . n 
A 1 693 PRO 693 693 693 PRO PRO A . n 
A 1 694 PHE 694 694 694 PHE PHE A . n 
A 1 695 ILE 695 695 695 ILE ILE A . n 
A 1 696 PRO 696 696 696 PRO PRO A . n 
A 1 697 LEU 697 697 697 LEU LEU A . n 
A 1 698 ALA 698 698 698 ALA ALA A . n 
A 1 699 HIS 699 699 699 HIS HIS A . n 
A 1 700 TRP 700 700 700 TRP TRP A . n 
A 1 701 GLU 701 701 ?   ?   ?   A . n 
A 1 702 LYS 702 702 ?   ?   ?   A . n 
A 1 703 ASP 703 703 ?   ?   ?   A . n 
A 1 704 GLY 704 704 ?   ?   ?   A . n 
A 1 705 SER 705 705 705 SER SER A . n 
A 1 706 PRO 706 706 706 PRO PRO A . n 
A 1 707 GLN 707 707 707 GLN GLN A . n 
A 1 708 ILE 708 708 708 ILE ILE A . n 
A 1 709 VAL 709 709 709 VAL VAL A . n 
A 1 710 GLU 710 710 710 GLU GLU A . n 
A 1 711 ALA 711 711 711 ALA ALA A . n 
A 1 712 ASN 712 712 712 ASN ASN A . n 
A 1 713 GLU 713 713 713 GLU GLU A . n 
A 1 714 LEU 714 714 714 LEU LEU A . n 
A 1 715 ASP 715 715 715 ASP ASP A . n 
A 1 716 ASP 716 716 716 ASP ASP A . n 
A 1 717 PHE 717 717 717 PHE PHE A . n 
A 1 718 PHE 718 718 718 PHE PHE A . n 
A 1 719 ARG 719 719 719 ARG ARG A . n 
A 1 720 ARG 720 720 720 ARG ARG A . n 
A 1 721 HIS 721 721 721 HIS HIS A . n 
A 1 722 LEU 722 722 722 LEU LEU A . n 
A 1 723 ASP 723 723 723 ASP ASP A . n 
A 1 724 GLY 724 724 724 GLY GLY A . n 
A 1 725 VAL 725 725 725 VAL VAL A . n 
A 1 726 GLU 726 726 726 GLU GLU A . n 
A 1 727 VAL 727 727 727 VAL VAL A . n 
A 1 728 SER 728 728 728 SER SER A . n 
A 1 729 GLU 729 729 729 GLU GLU A . n 
A 1 730 TRP 730 730 730 TRP TRP A . n 
A 1 731 GLN 731 731 731 GLN GLN A . n 
A 1 732 ASP 732 732 732 ASP ASP A . n 
A 1 733 ILE 733 733 733 ILE ILE A . n 
A 1 734 LEU 734 734 734 LEU LEU A . n 
A 1 735 ASP 735 735 735 ASP ASP A . n 
A 1 736 LYS 736 736 736 LYS LYS A . n 
A 1 737 GLN 737 737 737 GLN GLN A . n 
A 1 738 ARG 738 738 738 ARG ARG A . n 
A 1 739 PHE 739 739 739 PHE PHE A . n 
A 1 740 PRO 740 740 740 PRO PRO A . n 
A 1 741 GLN 741 741 741 GLN GLN A . n 
A 1 742 PRO 742 742 742 PRO PRO A . n 
A 1 743 PRO 743 743 743 PRO PRO A . n 
A 1 744 ASP 744 744 ?   ?   ?   A . n 
A 1 745 ASN 745 745 ?   ?   ?   A . n 
A 1 746 SER 746 746 ?   ?   ?   A . n 
A 1 747 PHE 747 747 ?   ?   ?   A . n 
A 1 748 GLY 748 748 ?   ?   ?   A . n 
A 1 749 GLN 749 749 ?   ?   ?   A . n 
A 1 750 THR 750 750 ?   ?   ?   A . n 
A 1 751 ASP 751 751 ?   ?   ?   A . n 
A 1 752 GLN 752 752 ?   ?   ?   A . n 
A 1 753 PRO 753 753 ?   ?   ?   A . n 
A 1 754 LEU 754 754 ?   ?   ?   A . n 
A 1 755 LEU 755 755 755 LEU LEU A . n 
A 1 756 PRO 756 756 756 PRO PRO A . n 
A 1 757 GLU 757 757 757 GLU GLU A . n 
A 1 758 PRO 758 758 758 PRO PRO A . n 
A 1 759 PHE 759 759 759 PHE PHE A . n 
A 1 760 GLU 760 760 760 GLU GLU A . n 
A 1 761 SER 761 761 761 SER SER A . n 
A 1 762 TRP 762 762 762 TRP TRP A . n 
A 1 763 PHE 763 763 763 PHE PHE A . n 
A 1 764 GLY 764 764 764 GLY GLY A . n 
A 1 765 LEU 765 765 765 LEU LEU A . n 
A 1 766 LEU 766 766 766 LEU LEU A . n 
A 1 767 GLU 767 767 767 GLU GLU A . n 
A 1 768 SER 768 768 768 SER SER A . n 
A 1 769 ASP 769 769 769 ASP ASP A . n 
A 1 770 PRO 770 770 770 PRO PRO A . n 
A 1 771 LEU 771 771 771 LEU LEU A . n 
A 1 772 LYS 772 772 772 LYS LYS A . n 
A 1 773 HIS 773 773 773 HIS HIS A . n 
A 1 774 LYS 774 774 774 LYS LYS A . n 
A 1 775 TRP 775 775 775 TRP TRP A . n 
A 1 776 VAL 776 776 776 VAL VAL A . n 
A 1 777 TYR 777 777 777 TYR TYR A . n 
A 1 778 ARG 778 778 778 ARG ARG A . n 
A 1 779 LYS 779 779 779 LYS LYS A . n 
A 1 780 LEU 780 780 780 LEU LEU A . n 
A 1 781 GLN 781 781 781 GLN GLN A . n 
A 1 782 ARG 782 782 782 ARG ARG A . n 
A 1 783 TYR 783 783 783 TYR TYR A . n 
A 1 784 THR 784 784 784 THR THR A . n 
A 1 785 ILE 785 785 785 ILE ILE A . n 
A 1 786 THR 786 786 786 THR THR A . n 
A 1 787 VAL 787 787 787 VAL VAL A . n 
A 1 788 TYR 788 788 788 TYR TYR A . n 
A 1 789 GLU 789 789 789 GLU GLU A . n 
A 1 790 HIS 790 790 790 HIS HIS A . n 
A 1 791 GLU 791 791 791 GLU GLU A . n 
A 1 792 LEU 792 792 ?   ?   ?   A . n 
A 1 793 LYS 793 793 ?   ?   ?   A . n 
A 1 794 LYS 794 794 ?   ?   ?   A . n 
A 1 795 LEU 795 795 795 LEU LEU A . n 
A 1 796 PRO 796 796 796 PRO PRO A . n 
A 1 797 GLU 797 797 797 GLU GLU A . n 
A 1 798 HIS 798 798 798 HIS HIS A . n 
A 1 799 ALA 799 799 799 ALA ALA A . n 
A 1 800 VAL 800 800 800 VAL VAL A . n 
A 1 801 PHE 801 801 801 PHE PHE A . n 
A 1 802 SER 802 802 802 SER SER A . n 
A 1 803 ARG 803 803 803 ARG ARG A . n 
A 1 804 ALA 804 804 804 ALA ALA A . n 
A 1 805 GLY 805 805 805 GLY GLY A . n 
A 1 806 LEU 806 806 806 LEU LEU A . n 
A 1 807 LEU 807 807 807 LEU LEU A . n 
A 1 808 VAL 808 808 808 VAL VAL A . n 
A 1 809 LEU 809 809 809 LEU LEU A . n 
A 1 810 ASP 810 810 810 ASP ASP A . n 
A 1 811 LYS 811 811 811 LYS LYS A . n 
A 1 812 GLY 812 812 812 GLY GLY A . n 
A 1 813 TYR 813 813 813 TYR TYR A . n 
A 1 814 TYR 814 814 814 TYR TYR A . n 
A 1 815 LYS 815 815 815 LYS LYS A . n 
A 1 816 ALA 816 816 816 ALA ALA A . n 
A 1 817 VAL 817 817 817 VAL VAL A . n 
A 1 818 LEU 818 818 818 LEU LEU A . n 
A 1 819 GLY 819 819 819 GLY GLY A . n 
A 1 820 ALA 820 820 820 ALA ALA A . n 
A 1 821 ASP 821 821 821 ASP ASP A . n 
A 1 822 PHE 822 822 ?   ?   ?   A . n 
A 1 823 ASP 823 823 ?   ?   ?   A . n 
A 1 824 ASP 824 824 ?   ?   ?   A . n 
A 1 825 ALA 825 825 ?   ?   ?   A . n 
A 1 826 ALA 826 826 ?   ?   ?   A . n 
A 1 827 TRP 827 827 ?   ?   ?   A . n 
A 1 828 LEU 828 828 ?   ?   ?   A . n 
A 1 829 PRO 829 829 ?   ?   ?   A . n 
A 1 830 GLU 830 830 ?   ?   ?   A . n 
A 1 831 ASN 831 831 ?   ?   ?   A . n 
A 1 832 SER 832 832 ?   ?   ?   A . n 
A 1 833 VAL 833 833 ?   ?   ?   A . n 
A 1 834 LEU 834 834 ?   ?   ?   A . n 
A 1 835 GLY 835 835 ?   ?   ?   A . n 
A 1 836 GLY 836 836 ?   ?   ?   A . n 
A 1 837 SER 837 837 ?   ?   ?   A . n 
A 1 838 VAL 838 838 ?   ?   ?   A . n 
A 1 839 GLY 839 839 ?   ?   ?   A . n 
A 1 840 PRO 840 840 ?   ?   ?   A . n 
A 1 841 LYS 841 841 ?   ?   ?   A . n 
A 1 842 LYS 842 842 ?   ?   ?   A . n 
A 1 843 LYS 843 843 ?   ?   ?   A . n 
A 1 844 ARG 844 844 ?   ?   ?   A . n 
A 1 845 LYS 845 845 ?   ?   ?   A . n 
A 1 846 VAL 846 846 ?   ?   ?   A . n 
A 1 847 LEU 847 847 ?   ?   ?   A . n 
A 1 848 GLU 848 848 ?   ?   ?   A . n 
A 1 849 HIS 849 849 ?   ?   ?   A . n 
A 1 850 HIS 850 850 ?   ?   ?   A . n 
A 1 851 HIS 851 851 ?   ?   ?   A . n 
A 1 852 HIS 852 852 ?   ?   ?   A . n 
A 1 853 HIS 853 853 ?   ?   ?   A . n 
A 1 854 HIS 854 854 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        FE 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   FE 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 FE  1   901  882 FE  FE  A . 
C 2 FE  1   902  885 FE  FE  A . 
D 3 HOH 1   1001 312 HOH HOH A . 
D 3 HOH 2   1002 83  HOH HOH A . 
D 3 HOH 3   1003 295 HOH HOH A . 
D 3 HOH 4   1004 334 HOH HOH A . 
D 3 HOH 5   1005 97  HOH HOH A . 
D 3 HOH 6   1006 178 HOH HOH A . 
D 3 HOH 7   1007 154 HOH HOH A . 
D 3 HOH 8   1008 231 HOH HOH A . 
D 3 HOH 9   1009 91  HOH HOH A . 
D 3 HOH 10  1010 332 HOH HOH A . 
D 3 HOH 11  1011 131 HOH HOH A . 
D 3 HOH 12  1012 116 HOH HOH A . 
D 3 HOH 13  1013 108 HOH HOH A . 
D 3 HOH 14  1014 280 HOH HOH A . 
D 3 HOH 15  1015 224 HOH HOH A . 
D 3 HOH 16  1016 306 HOH HOH A . 
D 3 HOH 17  1017 185 HOH HOH A . 
D 3 HOH 18  1018 307 HOH HOH A . 
D 3 HOH 19  1019 132 HOH HOH A . 
D 3 HOH 20  1020 158 HOH HOH A . 
D 3 HOH 21  1021 146 HOH HOH A . 
D 3 HOH 22  1022 324 HOH HOH A . 
D 3 HOH 23  1023 251 HOH HOH A . 
D 3 HOH 24  1024 329 HOH HOH A . 
D 3 HOH 25  1025 274 HOH HOH A . 
D 3 HOH 26  1026 115 HOH HOH A . 
D 3 HOH 27  1027 262 HOH HOH A . 
D 3 HOH 28  1028 70  HOH HOH A . 
D 3 HOH 29  1029 29  HOH HOH A . 
D 3 HOH 30  1030 198 HOH HOH A . 
D 3 HOH 31  1031 81  HOH HOH A . 
D 3 HOH 32  1032 69  HOH HOH A . 
D 3 HOH 33  1033 117 HOH HOH A . 
D 3 HOH 34  1034 58  HOH HOH A . 
D 3 HOH 35  1035 104 HOH HOH A . 
D 3 HOH 36  1036 93  HOH HOH A . 
D 3 HOH 37  1037 68  HOH HOH A . 
D 3 HOH 38  1038 14  HOH HOH A . 
D 3 HOH 39  1039 7   HOH HOH A . 
D 3 HOH 40  1040 64  HOH HOH A . 
D 3 HOH 41  1041 15  HOH HOH A . 
D 3 HOH 42  1042 110 HOH HOH A . 
D 3 HOH 43  1043 138 HOH HOH A . 
D 3 HOH 44  1044 50  HOH HOH A . 
D 3 HOH 45  1045 243 HOH HOH A . 
D 3 HOH 46  1046 90  HOH HOH A . 
D 3 HOH 47  1047 155 HOH HOH A . 
D 3 HOH 48  1048 112 HOH HOH A . 
D 3 HOH 49  1049 207 HOH HOH A . 
D 3 HOH 50  1050 161 HOH HOH A . 
D 3 HOH 51  1051 17  HOH HOH A . 
D 3 HOH 52  1052 73  HOH HOH A . 
D 3 HOH 53  1053 255 HOH HOH A . 
D 3 HOH 54  1054 309 HOH HOH A . 
D 3 HOH 55  1055 194 HOH HOH A . 
D 3 HOH 56  1056 292 HOH HOH A . 
D 3 HOH 57  1057 263 HOH HOH A . 
D 3 HOH 58  1058 121 HOH HOH A . 
D 3 HOH 59  1059 101 HOH HOH A . 
D 3 HOH 60  1060 6   HOH HOH A . 
D 3 HOH 61  1061 38  HOH HOH A . 
D 3 HOH 62  1062 196 HOH HOH A . 
D 3 HOH 63  1063 75  HOH HOH A . 
D 3 HOH 64  1064 140 HOH HOH A . 
D 3 HOH 65  1065 337 HOH HOH A . 
D 3 HOH 66  1066 51  HOH HOH A . 
D 3 HOH 67  1067 130 HOH HOH A . 
D 3 HOH 68  1068 26  HOH HOH A . 
D 3 HOH 69  1069 150 HOH HOH A . 
D 3 HOH 70  1070 32  HOH HOH A . 
D 3 HOH 71  1071 279 HOH HOH A . 
D 3 HOH 72  1072 37  HOH HOH A . 
D 3 HOH 73  1073 342 HOH HOH A . 
D 3 HOH 74  1074 143 HOH HOH A . 
D 3 HOH 75  1075 246 HOH HOH A . 
D 3 HOH 76  1076 95  HOH HOH A . 
D 3 HOH 77  1077 304 HOH HOH A . 
D 3 HOH 78  1078 258 HOH HOH A . 
D 3 HOH 79  1079 80  HOH HOH A . 
D 3 HOH 80  1080 20  HOH HOH A . 
D 3 HOH 81  1081 308 HOH HOH A . 
D 3 HOH 82  1082 248 HOH HOH A . 
D 3 HOH 83  1083 133 HOH HOH A . 
D 3 HOH 84  1084 77  HOH HOH A . 
D 3 HOH 85  1085 21  HOH HOH A . 
D 3 HOH 86  1086 336 HOH HOH A . 
D 3 HOH 87  1087 169 HOH HOH A . 
D 3 HOH 88  1088 152 HOH HOH A . 
D 3 HOH 89  1089 211 HOH HOH A . 
D 3 HOH 90  1090 19  HOH HOH A . 
D 3 HOH 91  1091 31  HOH HOH A . 
D 3 HOH 92  1092 33  HOH HOH A . 
D 3 HOH 93  1093 253 HOH HOH A . 
D 3 HOH 94  1094 137 HOH HOH A . 
D 3 HOH 95  1095 86  HOH HOH A . 
D 3 HOH 96  1096 241 HOH HOH A . 
D 3 HOH 97  1097 98  HOH HOH A . 
D 3 HOH 98  1098 23  HOH HOH A . 
D 3 HOH 99  1099 74  HOH HOH A . 
D 3 HOH 100 1100 2   HOH HOH A . 
D 3 HOH 101 1101 139 HOH HOH A . 
D 3 HOH 102 1102 187 HOH HOH A . 
D 3 HOH 103 1103 10  HOH HOH A . 
D 3 HOH 104 1104 22  HOH HOH A . 
D 3 HOH 105 1105 172 HOH HOH A . 
D 3 HOH 106 1106 46  HOH HOH A . 
D 3 HOH 107 1107 347 HOH HOH A . 
D 3 HOH 108 1108 346 HOH HOH A . 
D 3 HOH 109 1109 190 HOH HOH A . 
D 3 HOH 110 1110 12  HOH HOH A . 
D 3 HOH 111 1111 240 HOH HOH A . 
D 3 HOH 112 1112 103 HOH HOH A . 
D 3 HOH 113 1113 5   HOH HOH A . 
D 3 HOH 114 1114 87  HOH HOH A . 
D 3 HOH 115 1115 219 HOH HOH A . 
D 3 HOH 116 1116 147 HOH HOH A . 
D 3 HOH 117 1117 173 HOH HOH A . 
D 3 HOH 118 1118 42  HOH HOH A . 
D 3 HOH 119 1119 39  HOH HOH A . 
D 3 HOH 120 1120 40  HOH HOH A . 
D 3 HOH 121 1121 184 HOH HOH A . 
D 3 HOH 122 1122 186 HOH HOH A . 
D 3 HOH 123 1123 62  HOH HOH A . 
D 3 HOH 124 1124 277 HOH HOH A . 
D 3 HOH 125 1125 157 HOH HOH A . 
D 3 HOH 126 1126 4   HOH HOH A . 
D 3 HOH 127 1127 9   HOH HOH A . 
D 3 HOH 128 1128 41  HOH HOH A . 
D 3 HOH 129 1129 301 HOH HOH A . 
D 3 HOH 130 1130 25  HOH HOH A . 
D 3 HOH 131 1131 202 HOH HOH A . 
D 3 HOH 132 1132 79  HOH HOH A . 
D 3 HOH 133 1133 92  HOH HOH A . 
D 3 HOH 134 1134 320 HOH HOH A . 
D 3 HOH 135 1135 45  HOH HOH A . 
D 3 HOH 136 1136 122 HOH HOH A . 
D 3 HOH 137 1137 230 HOH HOH A . 
D 3 HOH 138 1138 323 HOH HOH A . 
D 3 HOH 139 1139 322 HOH HOH A . 
D 3 HOH 140 1140 232 HOH HOH A . 
D 3 HOH 141 1141 188 HOH HOH A . 
D 3 HOH 142 1142 65  HOH HOH A . 
D 3 HOH 143 1143 212 HOH HOH A . 
D 3 HOH 144 1144 181 HOH HOH A . 
D 3 HOH 145 1145 299 HOH HOH A . 
D 3 HOH 146 1146 94  HOH HOH A . 
D 3 HOH 147 1147 213 HOH HOH A . 
D 3 HOH 148 1148 315 HOH HOH A . 
D 3 HOH 149 1149 48  HOH HOH A . 
D 3 HOH 150 1150 72  HOH HOH A . 
D 3 HOH 151 1151 76  HOH HOH A . 
D 3 HOH 152 1152 28  HOH HOH A . 
D 3 HOH 153 1153 8   HOH HOH A . 
D 3 HOH 154 1154 318 HOH HOH A . 
D 3 HOH 155 1155 195 HOH HOH A . 
D 3 HOH 156 1156 229 HOH HOH A . 
D 3 HOH 157 1157 239 HOH HOH A . 
D 3 HOH 158 1158 53  HOH HOH A . 
D 3 HOH 159 1159 144 HOH HOH A . 
D 3 HOH 160 1160 89  HOH HOH A . 
D 3 HOH 161 1161 166 HOH HOH A . 
D 3 HOH 162 1162 167 HOH HOH A . 
D 3 HOH 163 1163 63  HOH HOH A . 
D 3 HOH 164 1164 44  HOH HOH A . 
D 3 HOH 165 1165 11  HOH HOH A . 
D 3 HOH 166 1166 3   HOH HOH A . 
D 3 HOH 167 1167 134 HOH HOH A . 
D 3 HOH 168 1168 242 HOH HOH A . 
D 3 HOH 169 1169 71  HOH HOH A . 
D 3 HOH 170 1170 176 HOH HOH A . 
D 3 HOH 171 1171 197 HOH HOH A . 
D 3 HOH 172 1172 36  HOH HOH A . 
D 3 HOH 173 1173 303 HOH HOH A . 
D 3 HOH 174 1174 24  HOH HOH A . 
D 3 HOH 175 1175 244 HOH HOH A . 
D 3 HOH 176 1176 43  HOH HOH A . 
D 3 HOH 177 1177 203 HOH HOH A . 
D 3 HOH 178 1178 59  HOH HOH A . 
D 3 HOH 179 1179 16  HOH HOH A . 
D 3 HOH 180 1180 250 HOH HOH A . 
D 3 HOH 181 1181 57  HOH HOH A . 
D 3 HOH 182 1182 156 HOH HOH A . 
D 3 HOH 183 1183 151 HOH HOH A . 
D 3 HOH 184 1184 34  HOH HOH A . 
D 3 HOH 185 1185 99  HOH HOH A . 
D 3 HOH 186 1186 238 HOH HOH A . 
D 3 HOH 187 1187 96  HOH HOH A . 
D 3 HOH 188 1188 88  HOH HOH A . 
D 3 HOH 189 1189 216 HOH HOH A . 
D 3 HOH 190 1190 218 HOH HOH A . 
D 3 HOH 191 1191 66  HOH HOH A . 
D 3 HOH 192 1192 100 HOH HOH A . 
D 3 HOH 193 1193 204 HOH HOH A . 
D 3 HOH 194 1194 84  HOH HOH A . 
D 3 HOH 195 1195 52  HOH HOH A . 
D 3 HOH 196 1196 35  HOH HOH A . 
D 3 HOH 197 1197 273 HOH HOH A . 
D 3 HOH 198 1198 179 HOH HOH A . 
D 3 HOH 199 1199 125 HOH HOH A . 
D 3 HOH 200 1200 206 HOH HOH A . 
D 3 HOH 201 1201 296 HOH HOH A . 
D 3 HOH 202 1202 109 HOH HOH A . 
D 3 HOH 203 1203 148 HOH HOH A . 
D 3 HOH 204 1204 49  HOH HOH A . 
D 3 HOH 205 1205 124 HOH HOH A . 
D 3 HOH 206 1206 107 HOH HOH A . 
D 3 HOH 207 1207 281 HOH HOH A . 
D 3 HOH 208 1208 217 HOH HOH A . 
D 3 HOH 209 1209 78  HOH HOH A . 
D 3 HOH 210 1210 226 HOH HOH A . 
D 3 HOH 211 1211 225 HOH HOH A . 
D 3 HOH 212 1212 300 HOH HOH A . 
D 3 HOH 213 1213 102 HOH HOH A . 
D 3 HOH 214 1214 13  HOH HOH A . 
D 3 HOH 215 1215 55  HOH HOH A . 
D 3 HOH 216 1216 201 HOH HOH A . 
D 3 HOH 217 1217 311 HOH HOH A . 
D 3 HOH 218 1218 27  HOH HOH A . 
D 3 HOH 219 1219 123 HOH HOH A . 
D 3 HOH 220 1220 136 HOH HOH A . 
D 3 HOH 221 1221 237 HOH HOH A . 
D 3 HOH 222 1222 234 HOH HOH A . 
D 3 HOH 223 1223 18  HOH HOH A . 
D 3 HOH 224 1224 193 HOH HOH A . 
D 3 HOH 225 1225 168 HOH HOH A . 
D 3 HOH 226 1226 221 HOH HOH A . 
D 3 HOH 227 1227 105 HOH HOH A . 
D 3 HOH 228 1228 339 HOH HOH A . 
D 3 HOH 229 1229 128 HOH HOH A . 
D 3 HOH 230 1230 210 HOH HOH A . 
D 3 HOH 231 1231 119 HOH HOH A . 
D 3 HOH 232 1232 191 HOH HOH A . 
D 3 HOH 233 1233 82  HOH HOH A . 
D 3 HOH 234 1234 135 HOH HOH A . 
D 3 HOH 235 1235 223 HOH HOH A . 
D 3 HOH 236 1236 85  HOH HOH A . 
D 3 HOH 237 1237 67  HOH HOH A . 
D 3 HOH 238 1238 145 HOH HOH A . 
D 3 HOH 239 1239 214 HOH HOH A . 
D 3 HOH 240 1240 325 HOH HOH A . 
D 3 HOH 241 1241 120 HOH HOH A . 
D 3 HOH 242 1242 287 HOH HOH A . 
D 3 HOH 243 1243 208 HOH HOH A . 
D 3 HOH 244 1244 333 HOH HOH A . 
D 3 HOH 245 1245 338 HOH HOH A . 
D 3 HOH 246 1246 227 HOH HOH A . 
D 3 HOH 247 1247 222 HOH HOH A . 
D 3 HOH 248 1248 47  HOH HOH A . 
D 3 HOH 249 1249 265 HOH HOH A . 
D 3 HOH 250 1250 291 HOH HOH A . 
D 3 HOH 251 1251 313 HOH HOH A . 
D 3 HOH 252 1252 314 HOH HOH A . 
D 3 HOH 253 1253 275 HOH HOH A . 
D 3 HOH 254 1254 289 HOH HOH A . 
D 3 HOH 255 1255 284 HOH HOH A . 
D 3 HOH 256 1256 294 HOH HOH A . 
D 3 HOH 257 1257 56  HOH HOH A . 
D 3 HOH 258 1258 199 HOH HOH A . 
D 3 HOH 259 1259 129 HOH HOH A . 
D 3 HOH 260 1260 106 HOH HOH A . 
D 3 HOH 261 1261 189 HOH HOH A . 
D 3 HOH 262 1262 141 HOH HOH A . 
D 3 HOH 263 1263 160 HOH HOH A . 
D 3 HOH 264 1264 290 HOH HOH A . 
D 3 HOH 265 1265 271 HOH HOH A . 
D 3 HOH 266 1266 127 HOH HOH A . 
D 3 HOH 267 1267 268 HOH HOH A . 
D 3 HOH 268 1268 233 HOH HOH A . 
D 3 HOH 269 1269 149 HOH HOH A . 
D 3 HOH 270 1270 200 HOH HOH A . 
D 3 HOH 271 1271 257 HOH HOH A . 
D 3 HOH 272 1272 288 HOH HOH A . 
D 3 HOH 273 1273 180 HOH HOH A . 
D 3 HOH 274 1274 267 HOH HOH A . 
D 3 HOH 275 1275 182 HOH HOH A . 
D 3 HOH 276 1276 113 HOH HOH A . 
D 3 HOH 277 1277 170 HOH HOH A . 
D 3 HOH 278 1278 345 HOH HOH A . 
D 3 HOH 279 1279 249 HOH HOH A . 
D 3 HOH 280 1280 321 HOH HOH A . 
D 3 HOH 281 1281 330 HOH HOH A . 
D 3 HOH 282 1282 349 HOH HOH A . 
D 3 HOH 283 1283 236 HOH HOH A . 
D 3 HOH 284 1284 266 HOH HOH A . 
D 3 HOH 285 1285 335 HOH HOH A . 
D 3 HOH 286 1286 286 HOH HOH A . 
D 3 HOH 287 1287 252 HOH HOH A . 
D 3 HOH 288 1288 159 HOH HOH A . 
D 3 HOH 289 1289 183 HOH HOH A . 
D 3 HOH 290 1290 283 HOH HOH A . 
D 3 HOH 291 1291 297 HOH HOH A . 
D 3 HOH 292 1292 61  HOH HOH A . 
D 3 HOH 293 1293 114 HOH HOH A . 
D 3 HOH 294 1294 205 HOH HOH A . 
D 3 HOH 295 1295 163 HOH HOH A . 
D 3 HOH 296 1296 259 HOH HOH A . 
D 3 HOH 297 1297 293 HOH HOH A . 
D 3 HOH 298 1298 327 HOH HOH A . 
D 3 HOH 299 1299 215 HOH HOH A . 
D 3 HOH 300 1300 305 HOH HOH A . 
D 3 HOH 301 1301 260 HOH HOH A . 
D 3 HOH 302 1302 177 HOH HOH A . 
D 3 HOH 303 1303 118 HOH HOH A . 
D 3 HOH 304 1304 54  HOH HOH A . 
D 3 HOH 305 1305 162 HOH HOH A . 
D 3 HOH 306 1306 1   HOH HOH A . 
D 3 HOH 307 1307 340 HOH HOH A . 
D 3 HOH 308 1308 171 HOH HOH A . 
D 3 HOH 309 1309 111 HOH HOH A . 
D 3 HOH 310 1310 165 HOH HOH A . 
D 3 HOH 311 1311 343 HOH HOH A . 
D 3 HOH 312 1312 254 HOH HOH A . 
D 3 HOH 313 1313 326 HOH HOH A . 
D 3 HOH 314 1314 245 HOH HOH A . 
D 3 HOH 315 1315 228 HOH HOH A . 
D 3 HOH 316 1316 270 HOH HOH A . 
D 3 HOH 317 1317 247 HOH HOH A . 
D 3 HOH 318 1318 175 HOH HOH A . 
D 3 HOH 319 1319 344 HOH HOH A . 
D 3 HOH 320 1320 350 HOH HOH A . 
D 3 HOH 321 1321 30  HOH HOH A . 
D 3 HOH 322 1322 331 HOH HOH A . 
D 3 HOH 323 1323 174 HOH HOH A . 
D 3 HOH 324 1324 256 HOH HOH A . 
D 3 HOH 325 1325 235 HOH HOH A . 
D 3 HOH 326 1326 278 HOH HOH A . 
D 3 HOH 327 1327 126 HOH HOH A . 
D 3 HOH 328 1328 285 HOH HOH A . 
D 3 HOH 329 1329 282 HOH HOH A . 
D 3 HOH 330 1330 164 HOH HOH A . 
D 3 HOH 331 1331 209 HOH HOH A . 
D 3 HOH 332 1332 319 HOH HOH A . 
D 3 HOH 333 1333 276 HOH HOH A . 
D 3 HOH 334 1334 192 HOH HOH A . 
D 3 HOH 335 1335 142 HOH HOH A . 
D 3 HOH 336 1336 60  HOH HOH A . 
D 3 HOH 337 1337 351 HOH HOH A . 
D 3 HOH 338 1338 328 HOH HOH A . 
D 3 HOH 339 1339 153 HOH HOH A . 
D 3 HOH 340 1340 269 HOH HOH A . 
D 3 HOH 341 1341 264 HOH HOH A . 
D 3 HOH 342 1342 261 HOH HOH A . 
D 3 HOH 343 1343 272 HOH HOH A . 
D 3 HOH 344 1344 310 HOH HOH A . 
D 3 HOH 345 1345 317 HOH HOH A . 
D 3 HOH 346 1346 220 HOH HOH A . 
D 3 HOH 347 1347 316 HOH HOH A . 
D 3 HOH 348 1348 298 HOH HOH A . 
D 3 HOH 349 1349 341 HOH HOH A . 
D 3 HOH 350 1350 302 HOH HOH A . 
D 3 HOH 351 1351 348 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 247 ? CG  ? A LYS 247 CG  
2  1 Y 1 A LYS 247 ? CD  ? A LYS 247 CD  
3  1 Y 1 A LYS 247 ? CE  ? A LYS 247 CE  
4  1 Y 1 A LYS 247 ? NZ  ? A LYS 247 NZ  
5  1 Y 1 A ASN 248 ? CG  ? A ASN 248 CG  
6  1 Y 1 A ASN 248 ? OD1 ? A ASN 248 OD1 
7  1 Y 1 A ASN 248 ? ND2 ? A ASN 248 ND2 
8  1 Y 1 A ILE 456 ? CG1 ? A ILE 456 CG1 
9  1 Y 1 A ILE 456 ? CG2 ? A ILE 456 CG2 
10 1 Y 1 A ILE 456 ? CD1 ? A ILE 456 CD1 
11 1 Y 1 A LYS 461 ? CG  ? A LYS 461 CG  
12 1 Y 1 A LYS 461 ? CD  ? A LYS 461 CD  
13 1 Y 1 A LYS 461 ? CE  ? A LYS 461 CE  
14 1 Y 1 A LYS 461 ? NZ  ? A LYS 461 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   99.750 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZNS 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     124.970 
_cell.length_a_esd                 ? 
_cell.length_b                     73.330 
_cell.length_b_esd                 ? 
_cell.length_c                     104.420 
_cell.length_c_esd                 ? 
_cell.volume                       943088.558 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZNS 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZNS 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.45 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          49.75 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '10% (w/v) PEG 8000, 0.1M Na/K phosphate pH 6.2, 0.2M NaCl' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     125 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-06-08 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PAL/PLS BEAMLINE 5C (4A)' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   '5C (4A)' 
_diffrn_source.pdbx_synchrotron_site       PAL/PLS 
# 
_reflns.B_iso_Wilson_estimate                          37.44 
_reflns.entry_id                                       8ZNS 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.17 
_reflns.d_resolution_low                               29.09 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     49372 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.88 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          12.84 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.17 
_reflns_shell.d_res_low                                     2.248 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4905 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.804 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               42.41 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZNS 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.17 
_refine.ls_d_res_low                             29.09 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     49357 
_refine.ls_number_reflns_R_free                  2467 
_refine.ls_number_reflns_R_work                  46890 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.94 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1972 
_refine.ls_R_factor_R_free                       0.2486 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1946 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.3903 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2793 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.17 
_refine_hist.d_res_low                        29.09 
_refine_hist.number_atoms_solvent             351 
_refine_hist.number_atoms_total               6569 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        6216 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         2 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0090 ? 6358 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9946 ? 8602 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0530 ? 937  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0094 ? 1122 ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.9144 ? 842  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.17 2.21  . . 135 2570 99.89  . . . . 0.2793 . . . . . . . . . . . 0.3309 
'X-RAY DIFFRACTION' 2.21 2.26  . . 138 2607 99.89  . . . . 0.2840 . . . . . . . . . . . 0.3914 
'X-RAY DIFFRACTION' 2.26 2.31  . . 136 2580 99.93  . . . . 0.2760 . . . . . . . . . . . 0.3424 
'X-RAY DIFFRACTION' 2.31 2.36  . . 136 2590 99.89  . . . . 0.2563 . . . . . . . . . . . 0.3121 
'X-RAY DIFFRACTION' 2.36 2.42  . . 137 2609 99.96  . . . . 0.2392 . . . . . . . . . . . 0.2968 
'X-RAY DIFFRACTION' 2.42 2.48  . . 135 2567 99.96  . . . . 0.2444 . . . . . . . . . . . 0.3376 
'X-RAY DIFFRACTION' 2.48 2.56  . . 137 2598 99.96  . . . . 0.2308 . . . . . . . . . . . 0.2616 
'X-RAY DIFFRACTION' 2.56 2.64  . . 135 2588 99.82  . . . . 0.2205 . . . . . . . . . . . 0.2741 
'X-RAY DIFFRACTION' 2.64 2.73  . . 138 2606 100.00 . . . . 0.2156 . . . . . . . . . . . 0.2612 
'X-RAY DIFFRACTION' 2.73 2.84  . . 136 2590 100.00 . . . . 0.2159 . . . . . . . . . . . 0.2687 
'X-RAY DIFFRACTION' 2.84 2.97  . . 137 2608 99.96  . . . . 0.2042 . . . . . . . . . . . 0.2828 
'X-RAY DIFFRACTION' 2.97 3.13  . . 137 2600 100.00 . . . . 0.2011 . . . . . . . . . . . 0.2546 
'X-RAY DIFFRACTION' 3.13 3.32  . . 137 2602 99.89  . . . . 0.2033 . . . . . . . . . . . 0.2745 
'X-RAY DIFFRACTION' 3.32 3.58  . . 137 2613 100.00 . . . . 0.1831 . . . . . . . . . . . 0.2409 
'X-RAY DIFFRACTION' 3.58 3.94  . . 138 2617 100.00 . . . . 0.1725 . . . . . . . . . . . 0.2224 
'X-RAY DIFFRACTION' 3.94 4.51  . . 139 2630 99.96  . . . . 0.1523 . . . . . . . . . . . 0.1817 
'X-RAY DIFFRACTION' 4.51 5.67  . . 138 2627 99.96  . . . . 0.1650 . . . . . . . . . . . 0.2198 
'X-RAY DIFFRACTION' 5.68 29.09 . . 141 2688 99.93  . . . . 0.1796 . . . . . . . . . . . 0.2296 
# 
_struct.entry_id                     8ZNS 
_struct.title                        'Type I-C CRISPR-associated protein, Cas3' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZNS 
_struct_keywords.text            'Cas3, CRISPR-Cas system, genome editing, nuclease/helicase, DNA Binding protein, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    D0W8X3_NEILA 
_struct_ref.pdbx_db_accession          D0W8X3 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;NFDYIAHARQDSSKNWHSHPLQKHLQKVAQLAKRFAGRYGSLFAEYAGLLHDLGKFQESFQKYIRNASGFEKENAHLEDV
ESTKLRKIPHSTAGAKYAVERLNPFFGHLLAYLIAGHHAGLADWYDKGSLKRRLQQADDELAASLSGFVESSLPEDFFPL
SDDDLMRDFFAFWEDGAKLEELHIWMRFLFSCLVDADFLDTEAFMNGYADADTAQAAGLRPKFPGLDELHRRYEQYMAQL
SEKADKNSSLNQERHAILQQCFSAAETDRTLFSLTVPTGGGKTLASLGFALKHALKFGKKRIIYAIPFTSIIEQNANVFR
NALGDDVVLEHHSNLEVKEDKETAKTRLATENWDAPLIVTTNVQLFESLFAAKTSRCRKIHNIADSVVILDEAQQLPRDF
QKPITDMMRVLARDYGVTFVLCTATQPELGKNIDAFGRTILEGLPDVREIVADKIALSEKLRRVRIKMPPPNGETQSWQK
IADEIAARPCVLAVVNTRKHAQKLFAALPSNGIKLHLSANMCATHCSEVIALVRRYLALYRAGSLHKPLWLVSTQLIEAG
VDLDFPCVYRAMAGLDSIAQAAGRCNREGKLPQLGEVVVFRAEEGAPSGSLKQGQDITEEMLKAGLLDDPLSPLAFAEYF
RRFNGKGDVDKHGITTLLTAEASNENPLAIKFRTAAERFHLIDNQGVALIVPFIPLAHWEKDGSPQIVEANELDDFFRRH
LDGVEVSEWQDILDKQRFPQPPDNSFGQTDQPLLPEPFESWFGLLESDPLKHKWVYRKLQRYTITVYEHELKKLPEHAVF
SRAGLLVLDKGYYKAVLGADFDDAAWLPENSVL
;
_struct_ref.pdbx_align_begin           19 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8ZNS 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 2 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 834 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             D0W8X3 
_struct_ref_seq.db_align_beg                  19 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  851 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       2 
_struct_ref_seq.pdbx_auth_seq_align_end       834 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZNS MET A 1   ? UNP D0W8X3 ? ? 'initiating methionine' 1   1  
1 8ZNS GLY A 835 ? UNP D0W8X3 ? ? 'expression tag'        835 2  
1 8ZNS GLY A 836 ? UNP D0W8X3 ? ? 'expression tag'        836 3  
1 8ZNS SER A 837 ? UNP D0W8X3 ? ? 'expression tag'        837 4  
1 8ZNS VAL A 838 ? UNP D0W8X3 ? ? 'expression tag'        838 5  
1 8ZNS GLY A 839 ? UNP D0W8X3 ? ? 'expression tag'        839 6  
1 8ZNS PRO A 840 ? UNP D0W8X3 ? ? 'expression tag'        840 7  
1 8ZNS LYS A 841 ? UNP D0W8X3 ? ? 'expression tag'        841 8  
1 8ZNS LYS A 842 ? UNP D0W8X3 ? ? 'expression tag'        842 9  
1 8ZNS LYS A 843 ? UNP D0W8X3 ? ? 'expression tag'        843 10 
1 8ZNS ARG A 844 ? UNP D0W8X3 ? ? 'expression tag'        844 11 
1 8ZNS LYS A 845 ? UNP D0W8X3 ? ? 'expression tag'        845 12 
1 8ZNS VAL A 846 ? UNP D0W8X3 ? ? 'expression tag'        846 13 
1 8ZNS LEU A 847 ? UNP D0W8X3 ? ? 'expression tag'        847 14 
1 8ZNS GLU A 848 ? UNP D0W8X3 ? ? 'expression tag'        848 15 
1 8ZNS HIS A 849 ? UNP D0W8X3 ? ? 'expression tag'        849 16 
1 8ZNS HIS A 850 ? UNP D0W8X3 ? ? 'expression tag'        850 17 
1 8ZNS HIS A 851 ? UNP D0W8X3 ? ? 'expression tag'        851 18 
1 8ZNS HIS A 852 ? UNP D0W8X3 ? ? 'expression tag'        852 19 
1 8ZNS HIS A 853 ? UNP D0W8X3 ? ? 'expression tag'        853 20 
1 8ZNS HIS A 854 ? UNP D0W8X3 ? ? 'expression tag'        854 21 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 290   ? 
1 MORE         -29   ? 
1 'SSA (A^2)'  31940 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'light scattering' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 LEU A 22  ? GLY A 38  ? LEU A 22  GLY A 38  1 ? 17 
HELX_P HELX_P2  AA2 GLY A 41  ? HIS A 52  ? GLY A 41  HIS A 52  1 ? 12 
HELX_P HELX_P3  AA3 ASP A 53  ? PHE A 57  ? ASP A 53  PHE A 57  5 ? 5  
HELX_P HELX_P4  AA4 GLN A 58  ? ALA A 68  ? GLN A 58  ALA A 68  1 ? 11 
HELX_P HELX_P5  AA5 SER A 69  ? ASN A 75  ? SER A 69  ASN A 75  1 ? 7  
HELX_P HELX_P6  AA6 SER A 92  ? LEU A 103 ? SER A 92  LEU A 103 1 ? 12 
HELX_P HELX_P7  AA7 ASN A 104 ? GLY A 117 ? ASN A 104 GLY A 117 1 ? 14 
HELX_P HELX_P8  AA8 SER A 130 ? GLN A 137 ? SER A 130 GLN A 137 1 ? 8  
HELX_P HELX_P9  AA9 ALA A 138 ? SER A 152 ? ALA A 138 SER A 152 1 ? 15 
HELX_P HELX_P10 AB1 PRO A 155 ? PHE A 159 ? PRO A 155 PHE A 159 5 ? 5  
HELX_P HELX_P11 AB2 SER A 162 ? TRP A 174 ? SER A 162 TRP A 174 1 ? 13 
HELX_P HELX_P12 AB3 GLU A 182 ? ASN A 207 ? GLU A 182 ASN A 207 1 ? 26 
HELX_P HELX_P13 AB4 ASP A 211 ? GLY A 219 ? ASP A 211 GLY A 219 1 ? 9  
HELX_P HELX_P14 AB5 GLY A 226 ? ALA A 245 ? GLY A 226 ALA A 245 1 ? 20 
HELX_P HELX_P15 AB6 SER A 249 ? ALA A 266 ? SER A 249 ALA A 266 1 ? 18 
HELX_P HELX_P16 AB7 GLY A 282 ? PHE A 298 ? GLY A 282 PHE A 298 1 ? 17 
HELX_P HELX_P17 AB8 ILE A 312 ? GLY A 325 ? ILE A 312 GLY A 325 1 ? 14 
HELX_P HELX_P18 AB9 LYS A 339 ? GLU A 343 ? LYS A 339 GLU A 343 5 ? 5  
HELX_P HELX_P19 AC1 THR A 344 ? ALA A 350 ? THR A 344 ALA A 350 1 ? 7  
HELX_P HELX_P20 AC2 ASN A 363 ? PHE A 371 ? ASN A 363 PHE A 371 1 ? 9  
HELX_P HELX_P21 AC3 LYS A 374 ? ARG A 379 ? LYS A 374 ARG A 379 1 ? 6  
HELX_P HELX_P22 AC4 LYS A 380 ? ILE A 384 ? LYS A 380 ILE A 384 5 ? 5  
HELX_P HELX_P23 AC5 ALA A 394 ? LEU A 397 ? ALA A 394 LEU A 397 5 ? 4  
HELX_P HELX_P24 AC6 PRO A 398 ? ASP A 400 ? PRO A 398 ASP A 400 5 ? 3  
HELX_P HELX_P25 AC7 PHE A 401 ? TYR A 416 ? PHE A 401 TYR A 416 1 ? 16 
HELX_P HELX_P26 AC8 SER A 478 ? ALA A 488 ? SER A 478 ALA A 488 1 ? 11 
HELX_P HELX_P27 AC9 THR A 498 ? LEU A 509 ? THR A 498 LEU A 509 1 ? 12 
HELX_P HELX_P28 AD1 CYS A 523 ? ALA A 543 ? CYS A 523 ALA A 543 1 ? 21 
HELX_P HELX_P29 AD2 LEU A 557 ? GLU A 559 ? LEU A 557 GLU A 559 5 ? 3  
HELX_P HELX_P30 AD3 GLY A 575 ? GLY A 584 ? GLY A 575 GLY A 584 1 ? 10 
HELX_P HELX_P31 AD4 SER A 609 ? ALA A 625 ? SER A 609 ALA A 625 1 ? 17 
HELX_P HELX_P32 AD5 SER A 633 ? GLY A 646 ? SER A 633 GLY A 646 1 ? 14 
HELX_P HELX_P33 AD6 GLY A 654 ? THR A 660 ? GLY A 654 THR A 660 1 ? 7  
HELX_P HELX_P34 AD7 LYS A 672 ? HIS A 681 ? LYS A 672 HIS A 681 1 ? 10 
HELX_P HELX_P35 AD8 LEU A 682 ? ASN A 685 ? LEU A 682 ASN A 685 5 ? 4  
HELX_P HELX_P36 AD9 GLU A 710 ? ASN A 712 ? GLU A 710 ASN A 712 5 ? 3  
HELX_P HELX_P37 AE1 GLU A 713 ? ASP A 723 ? GLU A 713 ASP A 723 1 ? 11 
HELX_P HELX_P38 AE2 GLU A 726 ? GLN A 737 ? GLU A 726 GLN A 737 1 ? 12 
HELX_P HELX_P39 AE3 PRO A 756 ? ASP A 769 ? PRO A 756 ASP A 769 1 ? 14 
HELX_P HELX_P40 AE4 LYS A 774 ? GLN A 781 ? LYS A 774 GLN A 781 1 ? 8  
HELX_P HELX_P41 AE5 LYS A 811 ? TYR A 814 ? LYS A 811 TYR A 814 5 ? 4  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A HIS 25  NE2 ? ? ? 1_555 C FE  . FE ? ? A HIS 25  A FE  902  1_555 ? ? ? ? ? ? ? 2.149 ? ? 
metalc2 metalc ? ? A HIS 52  NE2 ? ? ? 1_555 C FE  . FE ? ? A HIS 52  A FE  902  1_555 ? ? ? ? ? ? ? 2.183 ? ? 
metalc3 metalc ? ? A ASP 53  OD1 ? ? ? 1_555 B FE  . FE ? ? A ASP 53  A FE  901  1_555 ? ? ? ? ? ? ? 2.499 ? ? 
metalc4 metalc ? ? A ASP 53  OD2 ? ? ? 1_555 C FE  . FE ? ? A ASP 53  A FE  902  1_555 ? ? ? ? ? ? ? 2.223 ? ? 
metalc5 metalc ? ? A HIS 91  NE2 ? ? ? 1_555 B FE  . FE ? ? A HIS 91  A FE  901  1_555 ? ? ? ? ? ? ? 2.077 ? ? 
metalc6 metalc ? ? A HIS 118 NE2 ? ? ? 1_555 B FE  . FE ? ? A HIS 118 A FE  901  1_555 ? ? ? ? ? ? ? 2.031 ? ? 
metalc7 metalc ? ? A HIS 119 NE2 ? ? ? 1_555 B FE  . FE ? ? A HIS 119 A FE  901  1_555 ? ? ? ? ? ? ? 2.161 ? ? 
metalc8 metalc ? ? A ASP 198 OD1 ? ? ? 1_555 C FE  . FE ? ? A ASP 198 A FE  902  1_555 ? ? ? ? ? ? ? 2.132 ? ? 
metalc9 metalc ? ? C FE  .   FE  ? ? ? 1_555 D HOH . O  ? ? A FE  902 A HOH 1306 1_555 ? ? ? ? ? ? ? 2.781 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 25  ? A HIS 25  ? 1_555 FE ? C FE . ? A FE 902 ? 1_555 NE2 ? A HIS 52  ? A HIS 52   ? 1_555 97.6  ? 
2  NE2 ? A HIS 25  ? A HIS 25  ? 1_555 FE ? C FE . ? A FE 902 ? 1_555 OD2 ? A ASP 53  ? A ASP 53   ? 1_555 88.8  ? 
3  NE2 ? A HIS 52  ? A HIS 52  ? 1_555 FE ? C FE . ? A FE 902 ? 1_555 OD2 ? A ASP 53  ? A ASP 53   ? 1_555 81.9  ? 
4  NE2 ? A HIS 25  ? A HIS 25  ? 1_555 FE ? C FE . ? A FE 902 ? 1_555 OD1 ? A ASP 198 ? A ASP 198  ? 1_555 91.9  ? 
5  NE2 ? A HIS 52  ? A HIS 52  ? 1_555 FE ? C FE . ? A FE 902 ? 1_555 OD1 ? A ASP 198 ? A ASP 198  ? 1_555 89.6  ? 
6  OD2 ? A ASP 53  ? A ASP 53  ? 1_555 FE ? C FE . ? A FE 902 ? 1_555 OD1 ? A ASP 198 ? A ASP 198  ? 1_555 171.5 ? 
7  NE2 ? A HIS 25  ? A HIS 25  ? 1_555 FE ? C FE . ? A FE 902 ? 1_555 O   ? D HOH .   ? A HOH 1306 ? 1_555 138.2 ? 
8  NE2 ? A HIS 52  ? A HIS 52  ? 1_555 FE ? C FE . ? A FE 902 ? 1_555 O   ? D HOH .   ? A HOH 1306 ? 1_555 124.0 ? 
9  OD2 ? A ASP 53  ? A ASP 53  ? 1_555 FE ? C FE . ? A FE 902 ? 1_555 O   ? D HOH .   ? A HOH 1306 ? 1_555 92.7  ? 
10 OD1 ? A ASP 198 ? A ASP 198 ? 1_555 FE ? C FE . ? A FE 902 ? 1_555 O   ? D HOH .   ? A HOH 1306 ? 1_555 92.4  ? 
11 OD1 ? A ASP 53  ? A ASP 53  ? 1_555 FE ? B FE . ? A FE 901 ? 1_555 NE2 ? A HIS 91  ? A HIS 91   ? 1_555 92.8  ? 
12 OD1 ? A ASP 53  ? A ASP 53  ? 1_555 FE ? B FE . ? A FE 901 ? 1_555 NE2 ? A HIS 118 ? A HIS 118  ? 1_555 89.4  ? 
13 NE2 ? A HIS 91  ? A HIS 91  ? 1_555 FE ? B FE . ? A FE 901 ? 1_555 NE2 ? A HIS 118 ? A HIS 118  ? 1_555 115.3 ? 
14 OD1 ? A ASP 53  ? A ASP 53  ? 1_555 FE ? B FE . ? A FE 901 ? 1_555 NE2 ? A HIS 119 ? A HIS 119  ? 1_555 178.8 ? 
15 NE2 ? A HIS 91  ? A HIS 91  ? 1_555 FE ? B FE . ? A FE 901 ? 1_555 NE2 ? A HIS 119 ? A HIS 119  ? 1_555 86.8  ? 
16 NE2 ? A HIS 118 ? A HIS 118 ? 1_555 FE ? B FE . ? A FE 901 ? 1_555 NE2 ? A HIS 119 ? A HIS 119  ? 1_555 89.7  ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 7 ? 
AA3 ? 6 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
AA6 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
AA2 5 6 ? parallel      
AA2 6 7 ? parallel      
AA3 1 2 ? parallel      
AA3 2 3 ? parallel      
AA3 3 4 ? parallel      
AA3 4 5 ? parallel      
AA3 5 6 ? parallel      
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 6   ? GLN A 11  ? ILE A 6   GLN A 11  
AA1 2 TRP A 17  ? PRO A 21  ? TRP A 17  PRO A 21  
AA2 1 VAL A 329 ? GLU A 331 ? VAL A 329 GLU A 331 
AA2 2 LEU A 358 ? THR A 362 ? LEU A 358 THR A 362 
AA2 3 ARG A 302 ? ILE A 307 ? ARG A 302 ILE A 307 
AA2 4 SER A 387 ? ASP A 392 ? SER A 387 ASP A 392 
AA2 5 THR A 419 ? THR A 424 ? THR A 419 THR A 424 
AA2 6 LEU A 272 ? THR A 276 ? LEU A 272 THR A 276 
AA2 7 ARG A 449 ? GLU A 450 ? ARG A 449 GLU A 450 
AA3 1 VAL A 465 ? LYS A 468 ? VAL A 465 LYS A 468 
AA3 2 GLY A 596 ? PHE A 601 ? GLY A 596 PHE A 601 
AA3 3 CYS A 568 ? ALA A 572 ? CYS A 568 ALA A 572 
AA3 4 CYS A 491 ? VAL A 496 ? CYS A 491 VAL A 496 
AA3 5 LEU A 550 ? THR A 555 ? LEU A 550 THR A 555 
AA3 6 ILE A 514 ? LEU A 518 ? ILE A 514 LEU A 518 
AA4 1 GLY A 687 ? ILE A 691 ? GLY A 687 ILE A 691 
AA4 2 THR A 784 ? TYR A 788 ? THR A 784 TYR A 788 
AA5 1 ALA A 698 ? HIS A 699 ? ALA A 698 HIS A 699 
AA5 2 GLN A 707 ? ILE A 708 ? GLN A 707 ILE A 708 
AA6 1 VAL A 800 ? ARG A 803 ? VAL A 800 ARG A 803 
AA6 2 LEU A 806 ? LEU A 809 ? LEU A 806 LEU A 809 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 7   ? N ALA A 7   O HIS A 20  ? O HIS A 20  
AA2 1 2 N LEU A 330 ? N LEU A 330 O LEU A 358 ? O LEU A 358 
AA2 2 3 O ILE A 359 ? O ILE A 359 N TYR A 305 ? N TYR A 305 
AA2 3 4 N ILE A 304 ? N ILE A 304 O ILE A 390 ? O ILE A 390 
AA2 4 5 N VAL A 389 ? N VAL A 389 O THR A 419 ? O THR A 419 
AA2 5 6 O PHE A 420 ? O PHE A 420 N PHE A 273 ? N PHE A 273 
AA2 6 7 N LEU A 272 ? N LEU A 272 O ARG A 449 ? O ARG A 449 
AA3 1 2 N LYS A 468 ? N LYS A 468 O VAL A 600 ? O VAL A 600 
AA3 2 3 O VAL A 599 ? O VAL A 599 N ARG A 571 ? N ARG A 571 
AA3 3 4 O TYR A 570 ? O TYR A 570 N VAL A 495 ? N VAL A 495 
AA3 4 5 N ALA A 494 ? N ALA A 494 O SER A 554 ? O SER A 554 
AA3 5 6 O VAL A 553 ? O VAL A 553 N LEU A 516 ? N LEU A 516 
AA4 1 2 N VAL A 688 ? N VAL A 688 O VAL A 787 ? O VAL A 787 
AA5 1 2 N HIS A 699 ? N HIS A 699 O GLN A 707 ? O GLN A 707 
AA6 1 2 N PHE A 801 ? N PHE A 801 O VAL A 808 ? O VAL A 808 
# 
_pdbx_entry_details.entry_id                   8ZNS 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O   A HOH 1235 ? ? O   A HOH 1334 ? ? 1.89 
2  1 OE1 A GLU 678  ? ? O   A HOH 1001 ? ? 1.92 
3  1 OE2 A GLU 529  ? ? O   A HOH 1002 ? ? 1.97 
4  1 O   A HOH 1169 ? ? O   A HOH 1310 ? ? 2.04 
5  1 NH2 A ARG 720  ? ? O   A HOH 1003 ? ? 2.06 
6  1 OE1 A GLU 604  ? ? O   A HOH 1004 ? ? 2.08 
7  1 ND2 A ASN 363  ? ? O   A HOH 1005 ? ? 2.08 
8  1 O   A HOH 1237 ? ? O   A HOH 1333 ? ? 2.09 
9  1 O   A HOH 1292 ? ? O   A HOH 1342 ? ? 2.09 
10 1 OD1 A ASP 649  ? ? O   A HOH 1006 ? ? 2.10 
11 1 NH2 A ARG 321  ? ? OE2 A GLU 331  ? ? 2.12 
12 1 NH1 A ARG 439  ? ? O   A HOH 1007 ? ? 2.13 
13 1 O   A GLN 686  ? ? O   A HOH 1008 ? ? 2.14 
14 1 OD1 A ASP 684  ? ? O   A HOH 1009 ? ? 2.15 
15 1 NH2 A ARG 535  ? ? O   A ASP 563  ? ? 2.19 
16 1 O   A HOH 1321 ? ? O   A HOH 1330 ? ? 2.19 
17 1 OE1 A GLU 343  ? ? O   A HOH 1010 ? ? 2.19 
18 1 O   A VAL 787  ? ? O   A HOH 1008 ? ? 2.19 
19 1 OD1 A ASP 157  ? ? O   A HOH 1011 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 40  ? ? -94.40  50.97   
2 1 ASP A 127 ? ? -100.73 -87.09  
3 1 ALA A 425 ? ? -90.47  35.89   
4 1 PRO A 446 ? ? -63.82  -178.36 
5 1 CYS A 491 ? ? -160.64 110.94  
6 1 ALA A 520 ? ? -68.48  3.62    
7 1 SER A 545 ? ? -140.03 16.98   
8 1 ALA A 603 ? ? -111.26 -169.88 
9 1 GLU A 604 ? ? -38.26  131.22  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       1351 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.09 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ASN 2   ? A ASN 2   
3  1 Y 1 A PHE 3   ? A PHE 3   
4  1 Y 1 A VAL 81  ? A VAL 81  
5  1 Y 1 A GLU 82  ? A GLU 82  
6  1 Y 1 A SER 83  ? A SER 83  
7  1 Y 1 A THR 84  ? A THR 84  
8  1 Y 1 A LYS 85  ? A LYS 85  
9  1 Y 1 A LEU 86  ? A LEU 86  
10 1 Y 1 A LEU 220 ? A LEU 220 
11 1 Y 1 A ARG 221 ? A ARG 221 
12 1 Y 1 A PRO 222 ? A PRO 222 
13 1 Y 1 A LYS 223 ? A LYS 223 
14 1 Y 1 A GLY 431 ? A GLY 431 
15 1 Y 1 A LYS 432 ? A LYS 432 
16 1 Y 1 A ASN 433 ? A ASN 433 
17 1 Y 1 A ALA 457 ? A ALA 457 
18 1 Y 1 A LEU 458 ? A LEU 458 
19 1 Y 1 A SER 459 ? A SER 459 
20 1 Y 1 A GLU 460 ? A GLU 460 
21 1 Y 1 A GLU 701 ? A GLU 701 
22 1 Y 1 A LYS 702 ? A LYS 702 
23 1 Y 1 A ASP 703 ? A ASP 703 
24 1 Y 1 A GLY 704 ? A GLY 704 
25 1 Y 1 A ASP 744 ? A ASP 744 
26 1 Y 1 A ASN 745 ? A ASN 745 
27 1 Y 1 A SER 746 ? A SER 746 
28 1 Y 1 A PHE 747 ? A PHE 747 
29 1 Y 1 A GLY 748 ? A GLY 748 
30 1 Y 1 A GLN 749 ? A GLN 749 
31 1 Y 1 A THR 750 ? A THR 750 
32 1 Y 1 A ASP 751 ? A ASP 751 
33 1 Y 1 A GLN 752 ? A GLN 752 
34 1 Y 1 A PRO 753 ? A PRO 753 
35 1 Y 1 A LEU 754 ? A LEU 754 
36 1 Y 1 A LEU 792 ? A LEU 792 
37 1 Y 1 A LYS 793 ? A LYS 793 
38 1 Y 1 A LYS 794 ? A LYS 794 
39 1 Y 1 A PHE 822 ? A PHE 822 
40 1 Y 1 A ASP 823 ? A ASP 823 
41 1 Y 1 A ASP 824 ? A ASP 824 
42 1 Y 1 A ALA 825 ? A ALA 825 
43 1 Y 1 A ALA 826 ? A ALA 826 
44 1 Y 1 A TRP 827 ? A TRP 827 
45 1 Y 1 A LEU 828 ? A LEU 828 
46 1 Y 1 A PRO 829 ? A PRO 829 
47 1 Y 1 A GLU 830 ? A GLU 830 
48 1 Y 1 A ASN 831 ? A ASN 831 
49 1 Y 1 A SER 832 ? A SER 832 
50 1 Y 1 A VAL 833 ? A VAL 833 
51 1 Y 1 A LEU 834 ? A LEU 834 
52 1 Y 1 A GLY 835 ? A GLY 835 
53 1 Y 1 A GLY 836 ? A GLY 836 
54 1 Y 1 A SER 837 ? A SER 837 
55 1 Y 1 A VAL 838 ? A VAL 838 
56 1 Y 1 A GLY 839 ? A GLY 839 
57 1 Y 1 A PRO 840 ? A PRO 840 
58 1 Y 1 A LYS 841 ? A LYS 841 
59 1 Y 1 A LYS 842 ? A LYS 842 
60 1 Y 1 A LYS 843 ? A LYS 843 
61 1 Y 1 A ARG 844 ? A ARG 844 
62 1 Y 1 A LYS 845 ? A LYS 845 
63 1 Y 1 A VAL 846 ? A VAL 846 
64 1 Y 1 A LEU 847 ? A LEU 847 
65 1 Y 1 A GLU 848 ? A GLU 848 
66 1 Y 1 A HIS 849 ? A HIS 849 
67 1 Y 1 A HIS 850 ? A HIS 850 
68 1 Y 1 A HIS 851 ? A HIS 851 
69 1 Y 1 A HIS 852 ? A HIS 852 
70 1 Y 1 A HIS 853 ? A HIS 853 
71 1 Y 1 A HIS 854 ? A HIS 854 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
FE  FE   FE N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
HIS N    N  N N 138 
HIS CA   C  N S 139 
HIS C    C  N N 140 
HIS O    O  N N 141 
HIS CB   C  N N 142 
HIS CG   C  Y N 143 
HIS ND1  N  Y N 144 
HIS CD2  C  Y N 145 
HIS CE1  C  Y N 146 
HIS NE2  N  Y N 147 
HIS OXT  O  N N 148 
HIS H    H  N N 149 
HIS H2   H  N N 150 
HIS HA   H  N N 151 
HIS HB2  H  N N 152 
HIS HB3  H  N N 153 
HIS HD1  H  N N 154 
HIS HD2  H  N N 155 
HIS HE1  H  N N 156 
HIS HE2  H  N N 157 
HIS HXT  H  N N 158 
HOH O    O  N N 159 
HOH H1   H  N N 160 
HOH H2   H  N N 161 
ILE N    N  N N 162 
ILE CA   C  N S 163 
ILE C    C  N N 164 
ILE O    O  N N 165 
ILE CB   C  N S 166 
ILE CG1  C  N N 167 
ILE CG2  C  N N 168 
ILE CD1  C  N N 169 
ILE OXT  O  N N 170 
ILE H    H  N N 171 
ILE H2   H  N N 172 
ILE HA   H  N N 173 
ILE HB   H  N N 174 
ILE HG12 H  N N 175 
ILE HG13 H  N N 176 
ILE HG21 H  N N 177 
ILE HG22 H  N N 178 
ILE HG23 H  N N 179 
ILE HD11 H  N N 180 
ILE HD12 H  N N 181 
ILE HD13 H  N N 182 
ILE HXT  H  N N 183 
LEU N    N  N N 184 
LEU CA   C  N S 185 
LEU C    C  N N 186 
LEU O    O  N N 187 
LEU CB   C  N N 188 
LEU CG   C  N N 189 
LEU CD1  C  N N 190 
LEU CD2  C  N N 191 
LEU OXT  O  N N 192 
LEU H    H  N N 193 
LEU H2   H  N N 194 
LEU HA   H  N N 195 
LEU HB2  H  N N 196 
LEU HB3  H  N N 197 
LEU HG   H  N N 198 
LEU HD11 H  N N 199 
LEU HD12 H  N N 200 
LEU HD13 H  N N 201 
LEU HD21 H  N N 202 
LEU HD22 H  N N 203 
LEU HD23 H  N N 204 
LEU HXT  H  N N 205 
LYS N    N  N N 206 
LYS CA   C  N S 207 
LYS C    C  N N 208 
LYS O    O  N N 209 
LYS CB   C  N N 210 
LYS CG   C  N N 211 
LYS CD   C  N N 212 
LYS CE   C  N N 213 
LYS NZ   N  N N 214 
LYS OXT  O  N N 215 
LYS H    H  N N 216 
LYS H2   H  N N 217 
LYS HA   H  N N 218 
LYS HB2  H  N N 219 
LYS HB3  H  N N 220 
LYS HG2  H  N N 221 
LYS HG3  H  N N 222 
LYS HD2  H  N N 223 
LYS HD3  H  N N 224 
LYS HE2  H  N N 225 
LYS HE3  H  N N 226 
LYS HZ1  H  N N 227 
LYS HZ2  H  N N 228 
LYS HZ3  H  N N 229 
LYS HXT  H  N N 230 
MET N    N  N N 231 
MET CA   C  N S 232 
MET C    C  N N 233 
MET O    O  N N 234 
MET CB   C  N N 235 
MET CG   C  N N 236 
MET SD   S  N N 237 
MET CE   C  N N 238 
MET OXT  O  N N 239 
MET H    H  N N 240 
MET H2   H  N N 241 
MET HA   H  N N 242 
MET HB2  H  N N 243 
MET HB3  H  N N 244 
MET HG2  H  N N 245 
MET HG3  H  N N 246 
MET HE1  H  N N 247 
MET HE2  H  N N 248 
MET HE3  H  N N 249 
MET HXT  H  N N 250 
PHE N    N  N N 251 
PHE CA   C  N S 252 
PHE C    C  N N 253 
PHE O    O  N N 254 
PHE CB   C  N N 255 
PHE CG   C  Y N 256 
PHE CD1  C  Y N 257 
PHE CD2  C  Y N 258 
PHE CE1  C  Y N 259 
PHE CE2  C  Y N 260 
PHE CZ   C  Y N 261 
PHE OXT  O  N N 262 
PHE H    H  N N 263 
PHE H2   H  N N 264 
PHE HA   H  N N 265 
PHE HB2  H  N N 266 
PHE HB3  H  N N 267 
PHE HD1  H  N N 268 
PHE HD2  H  N N 269 
PHE HE1  H  N N 270 
PHE HE2  H  N N 271 
PHE HZ   H  N N 272 
PHE HXT  H  N N 273 
PRO N    N  N N 274 
PRO CA   C  N S 275 
PRO C    C  N N 276 
PRO O    O  N N 277 
PRO CB   C  N N 278 
PRO CG   C  N N 279 
PRO CD   C  N N 280 
PRO OXT  O  N N 281 
PRO H    H  N N 282 
PRO HA   H  N N 283 
PRO HB2  H  N N 284 
PRO HB3  H  N N 285 
PRO HG2  H  N N 286 
PRO HG3  H  N N 287 
PRO HD2  H  N N 288 
PRO HD3  H  N N 289 
PRO HXT  H  N N 290 
SER N    N  N N 291 
SER CA   C  N S 292 
SER C    C  N N 293 
SER O    O  N N 294 
SER CB   C  N N 295 
SER OG   O  N N 296 
SER OXT  O  N N 297 
SER H    H  N N 298 
SER H2   H  N N 299 
SER HA   H  N N 300 
SER HB2  H  N N 301 
SER HB3  H  N N 302 
SER HG   H  N N 303 
SER HXT  H  N N 304 
THR N    N  N N 305 
THR CA   C  N S 306 
THR C    C  N N 307 
THR O    O  N N 308 
THR CB   C  N R 309 
THR OG1  O  N N 310 
THR CG2  C  N N 311 
THR OXT  O  N N 312 
THR H    H  N N 313 
THR H2   H  N N 314 
THR HA   H  N N 315 
THR HB   H  N N 316 
THR HG1  H  N N 317 
THR HG21 H  N N 318 
THR HG22 H  N N 319 
THR HG23 H  N N 320 
THR HXT  H  N N 321 
TRP N    N  N N 322 
TRP CA   C  N S 323 
TRP C    C  N N 324 
TRP O    O  N N 325 
TRP CB   C  N N 326 
TRP CG   C  Y N 327 
TRP CD1  C  Y N 328 
TRP CD2  C  Y N 329 
TRP NE1  N  Y N 330 
TRP CE2  C  Y N 331 
TRP CE3  C  Y N 332 
TRP CZ2  C  Y N 333 
TRP CZ3  C  Y N 334 
TRP CH2  C  Y N 335 
TRP OXT  O  N N 336 
TRP H    H  N N 337 
TRP H2   H  N N 338 
TRP HA   H  N N 339 
TRP HB2  H  N N 340 
TRP HB3  H  N N 341 
TRP HD1  H  N N 342 
TRP HE1  H  N N 343 
TRP HE3  H  N N 344 
TRP HZ2  H  N N 345 
TRP HZ3  H  N N 346 
TRP HH2  H  N N 347 
TRP HXT  H  N N 348 
TYR N    N  N N 349 
TYR CA   C  N S 350 
TYR C    C  N N 351 
TYR O    O  N N 352 
TYR CB   C  N N 353 
TYR CG   C  Y N 354 
TYR CD1  C  Y N 355 
TYR CD2  C  Y N 356 
TYR CE1  C  Y N 357 
TYR CE2  C  Y N 358 
TYR CZ   C  Y N 359 
TYR OH   O  N N 360 
TYR OXT  O  N N 361 
TYR H    H  N N 362 
TYR H2   H  N N 363 
TYR HA   H  N N 364 
TYR HB2  H  N N 365 
TYR HB3  H  N N 366 
TYR HD1  H  N N 367 
TYR HD2  H  N N 368 
TYR HE1  H  N N 369 
TYR HE2  H  N N 370 
TYR HH   H  N N 371 
TYR HXT  H  N N 372 
VAL N    N  N N 373 
VAL CA   C  N S 374 
VAL C    C  N N 375 
VAL O    O  N N 376 
VAL CB   C  N N 377 
VAL CG1  C  N N 378 
VAL CG2  C  N N 379 
VAL OXT  O  N N 380 
VAL H    H  N N 381 
VAL H2   H  N N 382 
VAL HA   H  N N 383 
VAL HB   H  N N 384 
VAL HG11 H  N N 385 
VAL HG12 H  N N 386 
VAL HG13 H  N N 387 
VAL HG21 H  N N 388 
VAL HG22 H  N N 389 
VAL HG23 H  N N 390 
VAL HXT  H  N N 391 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'National Research Foundation (NRF, Korea)' 
_pdbx_audit_support.country                'Korea, Republic Of' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8ZNS 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008002 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001375 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013637 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009717 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C    ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
FE   ? ? ?        ?       ? ? ?        ?        ? ? ?   ? ? 
FE3+ ? ? 22.89238 ?       ? ? 3.59715  ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N    ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O    ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O1-  ? ? 5.12366  3.84317 ? ? 3.49406  27.47979 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S    ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASP A 1 4   ? 55.50052  -11.53420 7.25279   1.000 62.48762  ?  4    ASP A N   1 
ATOM   2    C  CA  . ASP A 1 4   ? 54.36826  -11.75933 6.36691   1.000 60.95424  ?  4    ASP A CA  1 
ATOM   3    C  C   . ASP A 1 4   ? 53.22316  -10.83576 6.76913   1.000 53.43378  ?  4    ASP A C   1 
ATOM   4    O  O   . ASP A 1 4   ? 53.26051  -10.22725 7.83585   1.000 51.28104  ?  4    ASP A O   1 
ATOM   5    C  CB  . ASP A 1 4   ? 53.91776  -13.21921 6.41297   1.000 63.00843  ?  4    ASP A CB  1 
ATOM   6    C  CG  . ASP A 1 4   ? 52.91155  -13.48094 7.52491   1.000 69.13085  ?  4    ASP A CG  1 
ATOM   7    O  OD1 . ASP A 1 4   ? 53.07431  -12.87643 8.61173   1.000 69.63382  -1 4    ASP A OD1 1 
ATOM   8    O  OD2 . ASP A 1 4   ? 51.94991  -14.26956 7.30898   1.000 71.91857  -1 4    ASP A OD2 1 
ATOM   9    N  N   . TYR A 1 5   ? 52.19320  -10.77328 5.93078   1.000 46.66807  ?  5    TYR A N   1 
ATOM   10   C  CA  . TYR A 1 5   ? 51.17535  -9.73077  6.03365   1.000 47.09023  ?  5    TYR A CA  1 
ATOM   11   C  C   . TYR A 1 5   ? 50.19254  -10.01216 7.16367   1.000 44.57711  ?  5    TYR A C   1 
ATOM   12   O  O   . TYR A 1 5   ? 49.67484  -11.13074 7.28892   1.000 40.07053  ?  5    TYR A O   1 
ATOM   13   C  CB  . TYR A 1 5   ? 50.44867  -9.60474  4.69627   1.000 44.59602  ?  5    TYR A CB  1 
ATOM   14   C  CG  . TYR A 1 5   ? 51.36826  -9.09529  3.60705   1.000 44.65545  ?  5    TYR A CG  1 
ATOM   15   C  CD1 . TYR A 1 5   ? 52.24651  -9.95180  2.94355   1.000 46.86932  ?  5    TYR A CD1 1 
ATOM   16   C  CD2 . TYR A 1 5   ? 51.38397  -7.74441  3.26575   1.000 41.78178  ?  5    TYR A CD2 1 
ATOM   17   C  CE1 . TYR A 1 5   ? 53.10223  -9.47511  1.94782   1.000 49.54017  ?  5    TYR A CE1 1 
ATOM   18   C  CE2 . TYR A 1 5   ? 52.22495  -7.26421  2.28051   1.000 44.33433  ?  5    TYR A CE2 1 
ATOM   19   C  CZ  . TYR A 1 5   ? 53.08089  -8.12992  1.62423   1.000 48.49199  ?  5    TYR A CZ  1 
ATOM   20   O  OH  . TYR A 1 5   ? 53.90570  -7.64202  0.65011   1.000 51.91745  ?  5    TYR A OH  1 
ATOM   21   N  N   . ILE A 1 6   ? 49.93982  -8.99428  7.99114   1.000 38.22107  ?  6    ILE A N   1 
ATOM   22   C  CA  . ILE A 1 6   ? 49.01711  -9.12910  9.10927   1.000 40.80692  ?  6    ILE A CA  1 
ATOM   23   C  C   . ILE A 1 6   ? 47.86659  -8.12629  8.98222   1.000 40.15741  ?  6    ILE A C   1 
ATOM   24   O  O   . ILE A 1 6   ? 47.97476  -7.07382  8.33752   1.000 41.41363  ?  6    ILE A O   1 
ATOM   25   C  CB  . ILE A 1 6   ? 49.72301  -8.97646  10.47626  1.000 45.14455  ?  6    ILE A CB  1 
ATOM   26   C  CG1 . ILE A 1 6   ? 50.30364  -7.57288  10.64895  1.000 46.48731  ?  6    ILE A CG1 1 
ATOM   27   C  CG2 . ILE A 1 6   ? 50.77938  -10.07761 10.68109  1.000 41.67711  ?  6    ILE A CG2 1 
ATOM   28   C  CD1 . ILE A 1 6   ? 50.74845  -7.27857  12.08065  1.000 43.12893  ?  6    ILE A CD1 1 
ATOM   29   N  N   . ALA A 1 7   ? 46.74771  -8.47919  9.62661   1.000 36.62902  ?  7    ALA A N   1 
ATOM   30   C  CA  . ALA A 1 7   ? 45.50879  -7.71304  9.62807   1.000 33.64038  ?  7    ALA A CA  1 
ATOM   31   C  C   . ALA A 1 7   ? 45.31425  -6.89362  10.88814  1.000 34.74557  ?  7    ALA A C   1 
ATOM   32   O  O   . ALA A 1 7   ? 44.71787  -5.81556  10.81882  1.000 32.59402  ?  7    ALA A O   1 
ATOM   33   C  CB  . ALA A 1 7   ? 44.30477  -8.64358  9.45198   1.000 34.72306  ?  7    ALA A CB  1 
ATOM   34   N  N   . HIS A 1 8   ? 45.80213  -7.38040  12.02959  1.000 36.02594  ?  8    HIS A N   1 
ATOM   35   C  CA  . HIS A 1 8   ? 45.64643  -6.71887  13.32271  1.000 34.02641  ?  8    HIS A CA  1 
ATOM   36   C  C   . HIS A 1 8   ? 46.85569  -7.03312  14.19678  1.000 35.71768  ?  8    HIS A C   1 
ATOM   37   O  O   . HIS A 1 8   ? 47.54862  -8.03539  14.00505  1.000 35.49312  ?  8    HIS A O   1 
ATOM   38   C  CB  . HIS A 1 8   ? 44.38016  -7.17299  14.08666  1.000 29.95854  ?  8    HIS A CB  1 
ATOM   39   C  CG  . HIS A 1 8   ? 43.13286  -7.19978  13.26007  1.000 34.93887  ?  8    HIS A CG  1 
ATOM   40   N  ND1 . HIS A 1 8   ? 42.67139  -8.34895  12.65434  1.000 36.65793  ?  8    HIS A ND1 1 
ATOM   41   C  CD2 . HIS A 1 8   ? 42.23270  -6.22764  12.96256  1.000 37.15178  ?  8    HIS A CD2 1 
ATOM   42   C  CE1 . HIS A 1 8   ? 41.55366  -8.08101  12.00077  1.000 34.42068  ?  8    HIS A CE1 1 
ATOM   43   N  NE2 . HIS A 1 8   ? 41.27049  -6.79882  12.16518  1.000 34.92888  ?  8    HIS A NE2 1 
ATOM   44   N  N   . ALA A 1 9   ? 47.08251  -6.18518  15.18913  1.000 33.80940  ?  9    ALA A N   1 
ATOM   45   C  CA  . ALA A 1 9   ? 48.07713  -6.47577  16.20521  1.000 37.93374  ?  9    ALA A CA  1 
ATOM   46   C  C   . ALA A 1 9   ? 47.54289  -6.03810  17.55990  1.000 40.36757  ?  9    ALA A C   1 
ATOM   47   O  O   . ALA A 1 9   ? 46.80232  -5.05372  17.66912  1.000 38.69511  ?  9    ALA A O   1 
ATOM   48   C  CB  . ALA A 1 9   ? 49.41916  -5.79451  15.89440  1.000 38.20062  ?  9    ALA A CB  1 
ATOM   49   N  N   . ARG A 1 10  ? 47.92131  -6.78630  18.59623  1.000 36.95253  ?  10   ARG A N   1 
ATOM   50   C  CA  . ARG A 1 10  ? 47.44283  -6.52948  19.94451  1.000 39.92816  ?  10   ARG A CA  1 
ATOM   51   C  C   . ARG A 1 10  ? 48.57826  -6.74507  20.92992  1.000 41.88087  ?  10   ARG A C   1 
ATOM   52   O  O   . ARG A 1 10  ? 49.55648  -7.43516  20.64203  1.000 40.85394  ?  10   ARG A O   1 
ATOM   53   C  CB  . ARG A 1 10  ? 46.25175  -7.43943  20.30963  1.000 39.03074  ?  10   ARG A CB  1 
ATOM   54   C  CG  . ARG A 1 10  ? 46.63505  -8.88461  20.55103  1.000 35.36620  ?  10   ARG A CG  1 
ATOM   55   C  CD  . ARG A 1 10  ? 45.41704  -9.72718  20.89674  1.000 36.71187  ?  10   ARG A CD  1 
ATOM   56   N  NE  . ARG A 1 10  ? 45.77670  -11.13538 20.97932  1.000 37.95213  ?  10   ARG A NE  1 
ATOM   57   C  CZ  . ARG A 1 10  ? 46.04932  -11.77329 22.11021  1.000 37.24672  ?  10   ARG A CZ  1 
ATOM   58   N  NH1 . ARG A 1 10  ? 45.98768  -11.16257 23.28047  1.000 35.44822  ?  10   ARG A NH1 1 
ATOM   59   N  NH2 . ARG A 1 10  ? 46.39964  -13.05591 22.06332  1.000 39.54943  ?  10   ARG A NH2 1 
ATOM   60   N  N   . GLN A 1 11  ? 48.43248  -6.15851  22.11021  1.000 41.45432  ?  11   GLN A N   1 
ATOM   61   C  CA  . GLN A 1 11  ? 49.40995  -6.33627  23.17129  1.000 43.89602  ?  11   GLN A CA  1 
ATOM   62   C  C   . GLN A 1 11  ? 48.69967  -6.88476  24.39287  1.000 41.38786  ?  11   GLN A C   1 
ATOM   63   O  O   . GLN A 1 11  ? 47.73331  -6.28121  24.86808  1.000 44.41970  ?  11   GLN A O   1 
ATOM   64   C  CB  . GLN A 1 11  ? 50.11591  -5.02344  23.49643  1.000 43.65029  ?  11   GLN A CB  1 
ATOM   65   C  CG  . GLN A 1 11  ? 51.34476  -5.19712  24.36631  1.000 45.64228  ?  11   GLN A CG  1 
ATOM   66   C  CD  . GLN A 1 11  ? 52.06523  -3.87875  24.61793  1.000 52.91026  ?  11   GLN A CD  1 
ATOM   67   O  OE1 . GLN A 1 11  ? 51.43747  -2.81100  24.66165  1.000 53.65684  ?  11   GLN A OE1 1 
ATOM   68   N  NE2 . GLN A 1 11  ? 53.39151  -3.94749  24.79113  1.000 55.02905  ?  11   GLN A NE2 1 
ATOM   69   N  N   . ASP A 1 12  ? 49.17774  -8.02477  24.89924  1.000 45.08963  ?  12   ASP A N   1 
ATOM   70   C  CA  . ASP A 1 12  ? 48.56869  -8.63568  26.07619  1.000 44.74046  ?  12   ASP A CA  1 
ATOM   71   C  C   . ASP A 1 12  ? 49.06999  -7.95719  27.35170  1.000 39.26133  ?  12   ASP A C   1 
ATOM   72   O  O   . ASP A 1 12  ? 50.02342  -7.18054  27.33696  1.000 45.10927  ?  12   ASP A O   1 
ATOM   73   C  CB  . ASP A 1 12  ? 48.83275  -10.14583 26.11323  1.000 44.45586  ?  12   ASP A CB  1 
ATOM   74   C  CG  . ASP A 1 12  ? 50.32280  -10.50714 26.22820  1.000 47.03620  ?  12   ASP A CG  1 
ATOM   75   O  OD1 . ASP A 1 12  ? 51.10224  -9.80129  26.91393  1.000 45.55097  ?  12   ASP A OD1 1 
ATOM   76   O  OD2 . ASP A 1 12  ? 50.71613  -11.55039 25.65345  1.000 48.72081  -1 12   ASP A OD2 1 
ATOM   77   N  N   . SER A 1 13  ? 48.42930  -8.28858  28.47536  1.000 42.74167  ?  13   SER A N   1 
ATOM   78   C  CA  . SER A 1 13  ? 48.72776  -7.61522  29.73624  1.000 46.68273  ?  13   SER A CA  1 
ATOM   79   C  C   . SER A 1 13  ? 50.15277  -7.86804  30.23483  1.000 47.36970  ?  13   SER A C   1 
ATOM   80   O  O   . SER A 1 13  ? 50.64188  -7.10269  31.07562  1.000 41.96018  ?  13   SER A O   1 
ATOM   81   C  CB  . SER A 1 13  ? 47.70505  -8.01756  30.80195  1.000 51.14687  ?  13   SER A CB  1 
ATOM   82   O  OG  . SER A 1 13  ? 47.46701  -9.41032  30.82568  1.000 47.72735  ?  13   SER A OG  1 
ATOM   83   N  N   . SER A 1 14  ? 50.84103  -8.90416  29.74255  1.000 47.62718  ?  14   SER A N   1 
ATOM   84   C  CA  . SER A 1 14  ? 52.25609  -9.06443  30.05308  1.000 43.92888  ?  14   SER A CA  1 
ATOM   85   C  C   . SER A 1 14  ? 53.13826  -8.28565  29.09601  1.000 45.80988  ?  14   SER A C   1 
ATOM   86   O  O   . SER A 1 14  ? 54.35987  -8.45327  29.13332  1.000 44.34560  ?  14   SER A O   1 
ATOM   87   C  CB  . SER A 1 14  ? 52.67365  -10.54164 30.03222  1.000 47.63439  ?  14   SER A CB  1 
ATOM   88   O  OG  . SER A 1 14  ? 51.62699  -11.38988 29.64048  1.000 44.28662  ?  14   SER A OG  1 
ATOM   89   N  N   . LYS A 1 15  ? 52.53442  -7.44829  28.24344  1.000 47.24489  ?  15   LYS A N   1 
ATOM   90   C  CA  . LYS A 1 15  ? 53.17782  -6.52305  27.30817  1.000 45.23168  ?  15   LYS A CA  1 
ATOM   91   C  C   . LYS A 1 15  ? 53.79832  -7.21742  26.09563  1.000 47.10182  ?  15   LYS A C   1 
ATOM   92   O  O   . LYS A 1 15  ? 54.62599  -6.61217  25.39027  1.000 52.52162  ?  15   LYS A O   1 
ATOM   93   C  CB  . LYS A 1 15  ? 54.23421  -5.62519  27.97732  1.000 46.14190  ?  15   LYS A CB  1 
ATOM   94   C  CG  . LYS A 1 15  ? 54.03153  -5.27855  29.45783  1.000 43.67827  ?  15   LYS A CG  1 
ATOM   95   C  CD  . LYS A 1 15  ? 52.77726  -4.46171  29.69606  1.000 56.10499  ?  15   LYS A CD  1 
ATOM   96   C  CE  . LYS A 1 15  ? 52.95594  -3.00042  29.32525  1.000 59.04310  ?  15   LYS A CE  1 
ATOM   97   N  NZ  . LYS A 1 15  ? 52.10291  -2.12451  30.18956  1.000 59.83757  ?  15   LYS A NZ  1 
ATOM   98   N  N   . ASN A 1 16  ? 53.41488  -8.45470  25.79828  1.000 43.13367  ?  16   ASN A N   1 
ATOM   99   C  CA  . ASN A 1 16  ? 53.84156  -9.09252  24.55370  1.000 44.48889  ?  16   ASN A CA  1 
ATOM   100  C  C   . ASN A 1 16  ? 52.87395  -8.79324  23.41123  1.000 45.59130  ?  16   ASN A C   1 
ATOM   101  O  O   . ASN A 1 16  ? 51.67168  -8.57113  23.62169  1.000 43.57082  ?  16   ASN A O   1 
ATOM   102  C  CB  . ASN A 1 16  ? 53.95897  -10.60254 24.72881  1.000 47.39765  ?  16   ASN A CB  1 
ATOM   103  C  CG  . ASN A 1 16  ? 54.83763  -10.97135 25.89751  1.000 51.21868  ?  16   ASN A CG  1 
ATOM   104  O  OD1 . ASN A 1 16  ? 55.91125  -10.38482 26.08809  1.000 51.43242  ?  16   ASN A OD1 1 
ATOM   105  N  ND2 . ASN A 1 16  ? 54.38143  -11.91732 26.70296  1.000 45.39204  ?  16   ASN A ND2 1 
ATOM   106  N  N   . TRP A 1 17  ? 53.40605  -8.82501  22.19151  1.000 38.71871  ?  17   TRP A N   1 
ATOM   107  C  CA  . TRP A 1 17  ? 52.65640  -8.45625  20.99502  1.000 42.76154  ?  17   TRP A CA  1 
ATOM   108  C  C   . TRP A 1 17  ? 52.24767  -9.70190  20.22070  1.000 36.04429  ?  17   TRP A C   1 
ATOM   109  O  O   . TRP A 1 17  ? 53.07041  -10.59353 20.00534  1.000 38.84123  ?  17   TRP A O   1 
ATOM   110  C  CB  . TRP A 1 17  ? 53.49118  -7.53606  20.10456  1.000 36.15770  ?  17   TRP A CB  1 
ATOM   111  C  CG  . TRP A 1 17  ? 53.55101  -6.14432  20.61748  1.000 40.66221  ?  17   TRP A CG  1 
ATOM   112  C  CD1 . TRP A 1 17  ? 54.52074  -5.60324  21.40825  1.000 39.38326  ?  17   TRP A CD1 1 
ATOM   113  C  CD2 . TRP A 1 17  ? 52.58205  -5.11803  20.40988  1.000 43.26485  ?  17   TRP A CD2 1 
ATOM   114  N  NE1 . TRP A 1 17  ? 54.21989  -4.29462  21.69481  1.000 45.47932  ?  17   TRP A NE1 1 
ATOM   115  C  CE2 . TRP A 1 17  ? 53.03492  -3.97165  21.09270  1.000 44.35472  ?  17   TRP A CE2 1 
ATOM   116  C  CE3 . TRP A 1 17  ? 51.36350  -5.05719  19.71599  1.000 44.85995  ?  17   TRP A CE3 1 
ATOM   117  C  CZ2 . TRP A 1 17  ? 52.32092  -2.77627  21.09556  1.000 49.49236  ?  17   TRP A CZ2 1 
ATOM   118  C  CZ3 . TRP A 1 17  ? 50.65706  -3.87720  19.71474  1.000 46.67660  ?  17   TRP A CZ3 1 
ATOM   119  C  CH2 . TRP A 1 17  ? 51.13283  -2.74780  20.40304  1.000 48.83570  ?  17   TRP A CH2 1 
ATOM   120  N  N   . HIS A 1 18  ? 50.98725  -9.75569  19.79313  1.000 35.51361  ?  18   HIS A N   1 
ATOM   121  C  CA  . HIS A 1 18  ? 50.51329  -10.82322 18.91842  1.000 41.49501  ?  18   HIS A CA  1 
ATOM   122  C  C   . HIS A 1 18  ? 49.91755  -10.20793 17.66137  1.000 37.24655  ?  18   HIS A C   1 
ATOM   123  O  O   . HIS A 1 18  ? 49.35948  -9.10618  17.70292  1.000 37.19445  ?  18   HIS A O   1 
ATOM   124  C  CB  . HIS A 1 18  ? 49.46438  -11.71712 19.61671  1.000 34.63132  ?  18   HIS A CB  1 
ATOM   125  C  CG  . HIS A 1 18  ? 49.83621  -12.09903 21.01560  1.000 41.69547  ?  18   HIS A CG  1 
ATOM   126  N  ND1 . HIS A 1 18  ? 50.15591  -13.39202 21.37665  1.000 46.80220  ?  18   HIS A ND1 1 
ATOM   127  C  CD2 . HIS A 1 18  ? 49.95008  -11.35487 22.14329  1.000 41.06690  ?  18   HIS A CD2 1 
ATOM   128  C  CE1 . HIS A 1 18  ? 50.45203  -13.42680 22.66504  1.000 43.98398  ?  18   HIS A CE1 1 
ATOM   129  N  NE2 . HIS A 1 18  ? 50.33831  -12.20324 23.15142  1.000 42.16060  ?  18   HIS A NE2 1 
ATOM   130  N  N   . SER A 1 19  ? 50.00465  -10.93420 16.54459  1.000 33.77856  ?  19   SER A N   1 
ATOM   131  C  CA  . SER A 1 19  ? 49.48629  -10.44513 15.27582  1.000 34.62178  ?  19   SER A CA  1 
ATOM   132  C  C   . SER A 1 19  ? 48.59571  -11.48379 14.60220  1.000 37.60904  ?  19   SER A C   1 
ATOM   133  O  O   . SER A 1 19  ? 48.75026  -12.69272 14.80890  1.000 34.74567  ?  19   SER A O   1 
ATOM   134  C  CB  . SER A 1 19  ? 50.61953  -10.02567 14.32990  1.000 34.20630  ?  19   SER A CB  1 
ATOM   135  O  OG  . SER A 1 19  ? 51.55560  -11.05893 14.12209  1.000 38.25048  ?  19   SER A OG  1 
ATOM   136  N  N   . HIS A 1 20  ? 47.64347  -10.97685 13.80144  1.000 34.94627  ?  20   HIS A N   1 
ATOM   137  C  CA  . HIS A 1 20  ? 46.61443  -11.75309 13.11251  1.000 36.24956  ?  20   HIS A CA  1 
ATOM   138  C  C   . HIS A 1 20  ? 46.97999  -11.89879 11.63567  1.000 39.59066  ?  20   HIS A C   1 
ATOM   139  O  O   . HIS A 1 20  ? 47.02695  -10.88869 10.92719  1.000 34.98190  ?  20   HIS A O   1 
ATOM   140  C  CB  . HIS A 1 20  ? 45.28289  -11.01875 13.27166  1.000 34.55031  ?  20   HIS A CB  1 
ATOM   141  C  CG  . HIS A 1 20  ? 44.06233  -11.84268 13.00592  1.000 34.26177  ?  20   HIS A CG  1 
ATOM   142  N  ND1 . HIS A 1 20  ? 42.81512  -11.26924 12.85317  1.000 34.54708  ?  20   HIS A ND1 1 
ATOM   143  C  CD2 . HIS A 1 20  ? 43.87974  -13.17863 12.87646  1.000 34.42942  ?  20   HIS A CD2 1 
ATOM   144  C  CE1 . HIS A 1 20  ? 41.91782  -12.21753 12.64236  1.000 34.58732  ?  20   HIS A CE1 1 
ATOM   145  N  NE2 . HIS A 1 20  ? 42.53932  -13.38359 12.63960  1.000 33.05862  ?  20   HIS A NE2 1 
ATOM   146  N  N   . PRO A 1 21  ? 47.28494  -13.09932 11.13229  1.000 39.81821  ?  21   PRO A N   1 
ATOM   147  C  CA  . PRO A 1 21  ? 47.73144  -13.23198 9.72854   1.000 36.60818  ?  21   PRO A CA  1 
ATOM   148  C  C   . PRO A 1 21  ? 46.64675  -12.84260 8.72096   1.000 39.35771  ?  21   PRO A C   1 
ATOM   149  O  O   . PRO A 1 21  ? 45.52233  -13.34277 8.77649   1.000 36.93853  ?  21   PRO A O   1 
ATOM   150  C  CB  . PRO A 1 21  ? 48.10539  -14.71555 9.60196   1.000 42.37430  ?  21   PRO A CB  1 
ATOM   151  C  CG  . PRO A 1 21  ? 48.16548  -15.25606 10.99779  1.000 43.43212  ?  21   PRO A CG  1 
ATOM   152  C  CD  . PRO A 1 21  ? 47.39849  -14.34712 11.90368  1.000 39.15207  ?  21   PRO A CD  1 
ATOM   153  N  N   . LEU A 1 22  ? 47.02082  -11.98722 7.75392   1.000 38.36411  ?  22   LEU A N   1 
ATOM   154  C  CA  . LEU A 1 22  ? 46.04103  -11.36853 6.85693   1.000 37.91124  ?  22   LEU A CA  1 
ATOM   155  C  C   . LEU A 1 22  ? 45.34395  -12.40731 5.97550   1.000 37.31792  ?  22   LEU A C   1 
ATOM   156  O  O   . LEU A 1 22  ? 44.11437  -12.39391 5.83632   1.000 35.23764  ?  22   LEU A O   1 
ATOM   157  C  CB  . LEU A 1 22  ? 46.71872  -10.29066 5.99574   1.000 32.06128  ?  22   LEU A CB  1 
ATOM   158  C  CG  . LEU A 1 22  ? 45.89516  -9.58406  4.89648   1.000 38.88634  ?  22   LEU A CG  1 
ATOM   159  C  CD1 . LEU A 1 22  ? 44.59322  -8.93756  5.45671   1.000 31.52607  ?  22   LEU A CD1 1 
ATOM   160  C  CD2 . LEU A 1 22  ? 46.72603  -8.53557  4.14902   1.000 38.43983  ?  22   LEU A CD2 1 
ATOM   161  N  N   . GLN A 1 23  ? 46.11045  -13.30682 5.36238   1.000 35.90047  ?  23   GLN A N   1 
ATOM   162  C  CA  . GLN A 1 23  ? 45.51197  -14.30582 4.48344   1.000 38.75180  ?  23   GLN A CA  1 
ATOM   163  C  C   . GLN A 1 23  ? 44.45397  -15.11316 5.22423   1.000 37.72746  ?  23   GLN A C   1 
ATOM   164  O  O   . GLN A 1 23  ? 43.34688  -15.34547 4.71485   1.000 38.28633  ?  23   GLN A O   1 
ATOM   165  C  CB  . GLN A 1 23  ? 46.59631  -15.23476 3.92845   1.000 38.98344  ?  23   GLN A CB  1 
ATOM   166  C  CG  . GLN A 1 23  ? 46.02571  -16.48282 3.29390   1.000 49.77237  ?  23   GLN A CG  1 
ATOM   167  C  CD  . GLN A 1 23  ? 47.07894  -17.50207 2.90020   1.000 55.33501  ?  23   GLN A CD  1 
ATOM   168  O  OE1 . GLN A 1 23  ? 48.25720  -17.37247 3.24725   1.000 55.03408  ?  23   GLN A OE1 1 
ATOM   169  N  NE2 . GLN A 1 23  ? 46.65669  -18.52095 2.15300   1.000 55.94904  ?  23   GLN A NE2 1 
ATOM   170  N  N   . LYS A 1 24  ? 44.78828  -15.55131 6.43764   1.000 42.08690  ?  24   LYS A N   1 
ATOM   171  C  CA  . LYS A 1 24  ? 43.87757  -16.37782 7.21572   1.000 37.80037  ?  24   LYS A CA  1 
ATOM   172  C  C   . LYS A 1 24  ? 42.59499  -15.62098 7.51681   1.000 37.42094  ?  24   LYS A C   1 
ATOM   173  O  O   . LYS A 1 24  ? 41.49486  -16.17063 7.39772   1.000 35.77974  ?  24   LYS A O   1 
ATOM   174  C  CB  . LYS A 1 24  ? 44.56494  -16.80502 8.51209   1.000 37.05887  ?  24   LYS A CB  1 
ATOM   175  C  CG  . LYS A 1 24  ? 43.93135  -18.01912 9.20910   1.000 51.26471  ?  24   LYS A CG  1 
ATOM   176  C  CD  . LYS A 1 24  ? 44.20124  -18.00952 10.72043  1.000 49.99571  ?  24   LYS A CD  1 
ATOM   177  C  CE  . LYS A 1 24  ? 43.52155  -19.19943 11.38779  1.000 56.64115  ?  24   LYS A CE  1 
ATOM   178  N  NZ  . LYS A 1 24  ? 43.99508  -20.50611 10.82170  1.000 49.45030  ?  24   LYS A NZ  1 
ATOM   179  N  N   . HIS A 1 25  ? 42.73088  -14.35852 7.92235   1.000 32.59422  ?  25   HIS A N   1 
ATOM   180  C  CA  . HIS A 1 25  ? 41.58335  -13.54821 8.28853   1.000 37.00300  ?  25   HIS A CA  1 
ATOM   181  C  C   . HIS A 1 25  ? 40.66658  -13.32863 7.08500   1.000 37.26801  ?  25   HIS A C   1 
ATOM   182  O  O   . HIS A 1 25  ? 39.43945  -13.43742 7.20741   1.000 35.12209  ?  25   HIS A O   1 
ATOM   183  C  CB  . HIS A 1 25  ? 42.09114  -12.23013 8.88489   1.000 27.88397  ?  25   HIS A CB  1 
ATOM   184  C  CG  . HIS A 1 25  ? 41.04265  -11.18031 9.06812   1.000 31.64663  ?  25   HIS A CG  1 
ATOM   185  N  ND1 . HIS A 1 25  ? 40.13056  -11.19881 10.10156  1.000 36.70766  ?  25   HIS A ND1 1 
ATOM   186  C  CD2 . HIS A 1 25  ? 40.78970  -10.04991 8.36492   1.000 26.28688  ?  25   HIS A CD2 1 
ATOM   187  C  CE1 . HIS A 1 25  ? 39.34651  -10.13778 10.01258  1.000 28.53822  ?  25   HIS A CE1 1 
ATOM   188  N  NE2 . HIS A 1 25  ? 39.72870  -9.42810  8.96742   1.000 30.20035  ?  25   HIS A NE2 1 
ATOM   189  N  N   . LEU A 1 26  ? 41.24828  -13.06293 5.90282   1.000 33.24439  ?  26   LEU A N   1 
ATOM   190  C  CA  . LEU A 1 26  ? 40.42682  -12.89934 4.71233   1.000 32.73171  ?  26   LEU A CA  1 
ATOM   191  C  C   . LEU A 1 26  ? 39.66610  -14.18185 4.39737   1.000 34.88886  ?  26   LEU A C   1 
ATOM   192  O  O   . LEU A 1 26  ? 38.48032  -14.13599 4.03974   1.000 32.74791  ?  26   LEU A O   1 
ATOM   193  C  CB  . LEU A 1 26  ? 41.27819  -12.46372 3.51374   1.000 34.05720  ?  26   LEU A CB  1 
ATOM   194  C  CG  . LEU A 1 26  ? 41.86394  -11.04016 3.50635   1.000 34.00074  ?  26   LEU A CG  1 
ATOM   195  C  CD1 . LEU A 1 26  ? 42.77566  -10.83601 2.27149   1.000 27.41734  ?  26   LEU A CD1 1 
ATOM   196  C  CD2 . LEU A 1 26  ? 40.77056  -10.00108 3.55055   1.000 32.99521  ?  26   LEU A CD2 1 
ATOM   197  N  N   . GLN A 1 27  ? 40.31241  -15.34175 4.54935   1.000 33.65630  ?  27   GLN A N   1 
ATOM   198  C  CA  . GLN A 1 27  ? 39.59253  -16.57129 4.21978   1.000 38.63659  ?  27   GLN A CA  1 
ATOM   199  C  C   . GLN A 1 27  ? 38.51233  -16.86738 5.24424   1.000 34.42749  ?  27   GLN A C   1 
ATOM   200  O  O   . GLN A 1 27  ? 37.41976  -17.32345 4.88790   1.000 38.50994  ?  27   GLN A O   1 
ATOM   201  C  CB  . GLN A 1 27  ? 40.55394  -17.75892 4.08976   1.000 39.40671  ?  27   GLN A CB  1 
ATOM   202  C  CG  . GLN A 1 27  ? 41.58643  -17.57570 2.97713   1.000 51.10210  ?  27   GLN A CG  1 
ATOM   203  C  CD  . GLN A 1 27  ? 42.67161  -18.63582 3.00232   1.000 59.83150  ?  27   GLN A CD  1 
ATOM   204  O  OE1 . GLN A 1 27  ? 43.59568  -18.59281 3.82855   1.000 57.47441  ?  27   GLN A OE1 1 
ATOM   205  N  NE2 . GLN A 1 27  ? 42.56925  -19.59661 2.08500   1.000 54.22812  ?  27   GLN A NE2 1 
ATOM   206  N  N   . LYS A 1 28  ? 38.80118  -16.61537 6.51908   1.000 34.24634  ?  28   LYS A N   1 
ATOM   207  C  CA  . LYS A 1 28  ? 37.84651  -16.92757 7.56899   1.000 35.28937  ?  28   LYS A CA  1 
ATOM   208  C  C   . LYS A 1 28  ? 36.65309  -15.99200 7.49825   1.000 34.41575  ?  28   LYS A C   1 
ATOM   209  O  O   . LYS A 1 28  ? 35.50724  -16.41785 7.69827   1.000 33.48063  ?  28   LYS A O   1 
ATOM   210  C  CB  . LYS A 1 28  ? 38.52427  -16.82577 8.93876   1.000 34.82368  ?  28   LYS A CB  1 
ATOM   211  C  CG  . LYS A 1 28  ? 39.49738  -17.96661 9.25788   1.000 44.40183  ?  28   LYS A CG  1 
ATOM   212  C  CD  . LYS A 1 28  ? 38.94525  -19.28977 8.76714   1.000 38.46694  ?  28   LYS A CD  1 
ATOM   213  C  CE  . LYS A 1 28  ? 39.69208  -20.49100 9.37822   1.000 52.74727  ?  28   LYS A CE  1 
ATOM   214  N  NZ  . LYS A 1 28  ? 39.25570  -21.80728 8.79732   1.000 46.93842  ?  28   LYS A NZ  1 
ATOM   215  N  N   . VAL A 1 29  ? 36.90686  -14.70757 7.23161   1.000 32.58060  ?  29   VAL A N   1 
ATOM   216  C  CA  . VAL A 1 29  ? 35.81653  -13.74737 7.14525   1.000 31.25283  ?  29   VAL A CA  1 
ATOM   217  C  C   . VAL A 1 29  ? 34.95946  -14.04153 5.93222   1.000 31.66068  ?  29   VAL A C   1 
ATOM   218  O  O   . VAL A 1 29  ? 33.72754  -13.98131 6.01544   1.000 33.03924  ?  29   VAL A O   1 
ATOM   219  C  CB  . VAL A 1 29  ? 36.36928  -12.31241 7.14540   1.000 30.61088  ?  29   VAL A CB  1 
ATOM   220  C  CG1 . VAL A 1 29  ? 35.30332  -11.30370 6.72812   1.000 28.31626  ?  29   VAL A CG1 1 
ATOM   221  C  CG2 . VAL A 1 29  ? 36.89276  -11.99257 8.53557   1.000 27.32410  ?  29   VAL A CG2 1 
ATOM   222  N  N   . ALA A 1 30  ? 35.58606  -14.44009 4.80913   1.000 31.33909  ?  30   ALA A N   1 
ATOM   223  C  CA  . ALA A 1 30  ? 34.81875  -14.85668 3.63375   1.000 33.55044  ?  30   ALA A CA  1 
ATOM   224  C  C   . ALA A 1 30  ? 33.91005  -16.03963 3.95050   1.000 32.89821  ?  30   ALA A C   1 
ATOM   225  O  O   . ALA A 1 30  ? 32.71618  -16.02324 3.63349   1.000 35.46037  ?  30   ALA A O   1 
ATOM   226  C  CB  . ALA A 1 30  ? 35.76536  -15.22435 2.48402   1.000 30.29348  ?  30   ALA A CB  1 
ATOM   227  N  N   . GLN A 1 31  ? 34.46647  -17.08216 4.57182   1.000 33.47315  ?  31   GLN A N   1 
ATOM   228  C  CA  . GLN A 1 31  ? 33.69343  -18.28756 4.84694   1.000 35.11394  ?  31   GLN A CA  1 
ATOM   229  C  C   . GLN A 1 31  ? 32.57662  -18.03833 5.86238   1.000 32.07590  ?  31   GLN A C   1 
ATOM   230  O  O   . GLN A 1 31  ? 31.45369  -18.52836 5.69446   1.000 33.56064  ?  31   GLN A O   1 
ATOM   231  C  CB  . GLN A 1 31  ? 34.64299  -19.39955 5.32449   1.000 36.06684  ?  31   GLN A CB  1 
ATOM   232  C  CG  . GLN A 1 31  ? 35.49847  -19.94889 4.16621   1.000 37.66326  ?  31   GLN A CG  1 
ATOM   233  C  CD  . GLN A 1 31  ? 36.68588  -20.78445 4.61763   1.000 41.97203  ?  31   GLN A CD  1 
ATOM   234  O  OE1 . GLN A 1 31  ? 36.86519  -21.05135 5.81437   1.000 43.40194  ?  31   GLN A OE1 1 
ATOM   235  N  NE2 . GLN A 1 31  ? 37.50133  -21.20593 3.65730   1.000 38.07945  ?  31   GLN A NE2 1 
ATOM   236  N  N   . LEU A 1 32  ? 32.86123  -17.28474 6.92407   1.000 34.50949  ?  32   LEU A N   1 
ATOM   237  C  CA  . LEU A 1 32  ? 31.85194  -17.06217 7.94642   1.000 33.56419  ?  32   LEU A CA  1 
ATOM   238  C  C   . LEU A 1 32  ? 30.74828  -16.14882 7.42105   1.000 32.06117  ?  32   LEU A C   1 
ATOM   239  O  O   . LEU A 1 32  ? 29.56892  -16.35963 7.72801   1.000 28.26021  ?  32   LEU A O   1 
ATOM   240  C  CB  . LEU A 1 32  ? 32.50827  -16.48885 9.21226   1.000 33.28296  ?  32   LEU A CB  1 
ATOM   241  C  CG  . LEU A 1 32  ? 31.59551  -16.33524 10.44179  1.000 29.06410  ?  32   LEU A CG  1 
ATOM   242  C  CD1 . LEU A 1 32  ? 30.83407  -17.62356 10.77420  1.000 29.30619  ?  32   LEU A CD1 1 
ATOM   243  C  CD2 . LEU A 1 32  ? 32.38559  -15.84020 11.63803  1.000 27.05821  ?  32   LEU A CD2 1 
ATOM   244  N  N   . ALA A 1 33  ? 31.10606  -15.16733 6.57696   1.000 30.84140  ?  33   ALA A N   1 
ATOM   245  C  CA  . ALA A 1 33  ? 30.08941  -14.31147 5.96400   1.000 32.67355  ?  33   ALA A CA  1 
ATOM   246  C  C   . ALA A 1 33  ? 29.21781  -15.09840 4.99731   1.000 32.07493  ?  33   ALA A C   1 
ATOM   247  O  O   . ALA A 1 33  ? 27.99170  -14.91240 4.96600   1.000 32.59626  ?  33   ALA A O   1 
ATOM   248  C  CB  . ALA A 1 33  ? 30.75320  -13.11702 5.25739   1.000 27.82226  ?  33   ALA A CB  1 
ATOM   249  N  N   . LYS A 1 34  ? 29.82846  -15.98414 4.19908   1.000 32.51105  ?  34   LYS A N   1 
ATOM   250  C  CA  . LYS A 1 34  ? 29.03828  -16.84402 3.32372   1.000 32.15304  ?  34   LYS A CA  1 
ATOM   251  C  C   . LYS A 1 34  ? 28.11861  -17.74427 4.13490   1.000 29.00571  ?  34   LYS A C   1 
ATOM   252  O  O   . LYS A 1 34  ? 26.97263  -18.00136 3.73715   1.000 29.43212  ?  34   LYS A O   1 
ATOM   253  C  CB  . LYS A 1 34  ? 29.95424  -17.68437 2.43200   1.000 33.86512  ?  34   LYS A CB  1 
ATOM   254  C  CG  . LYS A 1 34  ? 29.20491  -18.60901 1.47296   1.000 29.70141  ?  34   LYS A CG  1 
ATOM   255  C  CD  . LYS A 1 34  ? 30.17760  -19.45306 0.64680   1.000 38.45937  ?  34   LYS A CD  1 
ATOM   256  C  CE  . LYS A 1 34  ? 29.64018  -19.65281 -0.75667  1.000 42.92401  ?  34   LYS A CE  1 
ATOM   257  N  NZ  . LYS A 1 34  ? 30.57680  -20.41173 -1.61835  1.000 50.15035  ?  34   LYS A NZ  1 
ATOM   258  N  N   . ARG A 1 35  ? 28.59362  -18.22184 5.28562   1.000 30.22120  ?  35   ARG A N   1 
ATOM   259  C  CA  . ARG A 1 35  ? 27.72967  -19.03872 6.13952   1.000 34.75913  ?  35   ARG A CA  1 
ATOM   260  C  C   . ARG A 1 35  ? 26.54127  -18.23837 6.65948   1.000 28.77156  ?  35   ARG A C   1 
ATOM   261  O  O   . ARG A 1 35  ? 25.41051  -18.73379 6.68660   1.000 26.08543  ?  35   ARG A O   1 
ATOM   262  C  CB  . ARG A 1 35  ? 28.51285  -19.62573 7.31748   1.000 29.53577  ?  35   ARG A CB  1 
ATOM   263  C  CG  . ARG A 1 35  ? 27.61281  -20.46184 8.23518   1.000 31.57098  ?  35   ARG A CG  1 
ATOM   264  C  CD  . ARG A 1 35  ? 28.19895  -20.60365 9.63576   1.000 32.83683  ?  35   ARG A CD  1 
ATOM   265  N  NE  . ARG A 1 35  ? 29.42881  -21.37547 9.58919   1.000 36.80012  ?  35   ARG A NE  1 
ATOM   266  C  CZ  . ARG A 1 35  ? 30.27123  -21.49895 10.60267  1.000 42.95988  ?  35   ARG A CZ  1 
ATOM   267  N  NH1 . ARG A 1 35  ? 30.02369  -20.93722 11.77992  1.000 39.19398  ?  35   ARG A NH1 1 
ATOM   268  N  NH2 . ARG A 1 35  ? 31.38821  -22.20249 10.43039  1.000 41.62669  ?  35   ARG A NH2 1 
ATOM   269  N  N   . PHE A 1 36  ? 26.78597  -17.01275 7.12215   1.000 29.82180  ?  36   PHE A N   1 
ATOM   270  C  CA  . PHE A 1 36  ? 25.67993  -16.19495 7.62611   1.000 28.08151  ?  36   PHE A CA  1 
ATOM   271  C  C   . PHE A 1 36  ? 24.68295  -15.88098 6.51509   1.000 34.23437  ?  36   PHE A C   1 
ATOM   272  O  O   . PHE A 1 36  ? 23.46446  -15.88428 6.74156   1.000 36.72218  ?  36   PHE A O   1 
ATOM   273  C  CB  . PHE A 1 36  ? 26.19930  -14.89624 8.23888   1.000 29.76054  ?  36   PHE A CB  1 
ATOM   274  C  CG  . PHE A 1 36  ? 26.91056  -15.07179 9.55246   1.000 33.42921  ?  36   PHE A CG  1 
ATOM   275  C  CD1 . PHE A 1 36  ? 26.67312  -16.19549 10.35593  1.000 28.50003  ?  36   PHE A CD1 1 
ATOM   276  C  CD2 . PHE A 1 36  ? 27.81958  -14.11050 9.99205   1.000 26.24588  ?  36   PHE A CD2 1 
ATOM   277  C  CE1 . PHE A 1 36  ? 27.33529  -16.34801 11.57125  1.000 26.73174  ?  36   PHE A CE1 1 
ATOM   278  C  CE2 . PHE A 1 36  ? 28.47385  -14.24838 11.21255  1.000 27.32281  ?  36   PHE A CE2 1 
ATOM   279  C  CZ  . PHE A 1 36  ? 28.23874  -15.37542 12.00160  1.000 28.03663  ?  36   PHE A CZ  1 
ATOM   280  N  N   . ALA A 1 37  ? 25.17715  -15.62523 5.29580   1.000 33.88137  ?  37   ALA A N   1 
ATOM   281  C  CA  . ALA A 1 37  ? 24.27269  -15.21399 4.22076   1.000 34.95625  ?  37   ALA A CA  1 
ATOM   282  C  C   . ALA A 1 37  ? 23.42142  -16.36797 3.67652   1.000 34.14507  ?  37   ALA A C   1 
ATOM   283  O  O   . ALA A 1 37  ? 22.43467  -16.10745 2.98071   1.000 32.19240  ?  37   ALA A O   1 
ATOM   284  C  CB  . ALA A 1 37  ? 25.05560  -14.55186 3.09170   1.000 27.37134  ?  37   ALA A CB  1 
ATOM   285  N  N   . GLY A 1 38  ? 23.79394  -17.62438 3.95117   1.000 34.48523  ?  38   GLY A N   1 
ATOM   286  C  CA  . GLY A 1 38  ? 22.90625  -18.75621 3.69646   1.000 30.20820  ?  38   GLY A CA  1 
ATOM   287  C  C   . GLY A 1 38  ? 22.43984  -18.85435 2.25626   1.000 31.47190  ?  38   GLY A C   1 
ATOM   288  O  O   . GLY A 1 38  ? 23.21916  -18.78286 1.29949   1.000 30.92782  ?  38   GLY A O   1 
ATOM   289  N  N   . ARG A 1 39  ? 21.13463  -18.97303 2.10762   1.000 35.54031  ?  39   ARG A N   1 
ATOM   290  C  CA  . ARG A 1 39  ? 20.47144  -19.07509 0.82058   1.000 37.64933  ?  39   ARG A CA  1 
ATOM   291  C  C   . ARG A 1 39  ? 20.19874  -17.71692 0.19141   1.000 38.92071  ?  39   ARG A C   1 
ATOM   292  O  O   . ARG A 1 39  ? 19.62213  -17.66708 -0.89304  1.000 38.03418  ?  39   ARG A O   1 
ATOM   293  C  CB  . ARG A 1 39  ? 19.15088  -19.83881 0.98987   1.000 39.04645  ?  39   ARG A CB  1 
ATOM   294  C  CG  . ARG A 1 39  ? 18.09065  -19.04465 1.75295   1.000 46.96043  ?  39   ARG A CG  1 
ATOM   295  C  CD  . ARG A 1 39  ? 16.70289  -19.61473 1.54679   1.000 46.14396  ?  39   ARG A CD  1 
ATOM   296  N  NE  . ARG A 1 39  ? 15.69539  -18.96473 2.37513   1.000 49.01152  ?  39   ARG A NE  1 
ATOM   297  C  CZ  . ARG A 1 39  ? 14.84238  -18.03923 1.94615   1.000 52.69897  ?  39   ARG A CZ  1 
ATOM   298  N  NH1 . ARG A 1 39  ? 14.90186  -17.55542 0.70993   1.000 46.43818  ?  39   ARG A NH1 1 
ATOM   299  N  NH2 . ARG A 1 39  ? 13.89848  -17.59388 2.77658   1.000 48.91003  ?  39   ARG A NH2 1 
ATOM   300  N  N   . TYR A 1 40  ? 20.58635  -16.62428 0.84569   1.000 40.13524  ?  40   TYR A N   1 
ATOM   301  C  CA  . TYR A 1 40  ? 20.29011  -15.27483 0.36212   1.000 37.44364  ?  40   TYR A CA  1 
ATOM   302  C  C   . TYR A 1 40  ? 21.43880  -14.69410 -0.47119  1.000 38.97095  ?  40   TYR A C   1 
ATOM   303  O  O   . TYR A 1 40  ? 21.89349  -13.58050 -0.22599  1.000 37.61979  ?  40   TYR A O   1 
ATOM   304  C  CB  . TYR A 1 40  ? 19.96248  -14.37596 1.55605   1.000 39.12062  ?  40   TYR A CB  1 
ATOM   305  C  CG  . TYR A 1 40  ? 18.86570  -14.91647 2.43507   1.000 38.75027  ?  40   TYR A CG  1 
ATOM   306  C  CD1 . TYR A 1 40  ? 17.53715  -14.87426 2.02185   1.000 43.29246  ?  40   TYR A CD1 1 
ATOM   307  C  CD2 . TYR A 1 40  ? 19.14874  -15.48295 3.67226   1.000 35.91717  ?  40   TYR A CD2 1 
ATOM   308  C  CE1 . TYR A 1 40  ? 16.51494  -15.38489 2.81578   1.000 41.43227  ?  40   TYR A CE1 1 
ATOM   309  C  CE2 . TYR A 1 40  ? 18.13340  -15.98957 4.47918   1.000 38.82918  ?  40   TYR A CE2 1 
ATOM   310  C  CZ  . TYR A 1 40  ? 16.81530  -15.93682 4.04185   1.000 41.13603  ?  40   TYR A CZ  1 
ATOM   311  O  OH  . TYR A 1 40  ? 15.79475  -16.44520 4.82015   1.000 40.81753  ?  40   TYR A OH  1 
ATOM   312  N  N   . GLY A 1 41  ? 21.91914  -15.44010 -1.46696  1.000 38.03032  ?  41   GLY A N   1 
ATOM   313  C  CA  . GLY A 1 41  ? 22.99213  -14.97275 -2.32977  1.000 35.79179  ?  41   GLY A CA  1 
ATOM   314  C  C   . GLY A 1 41  ? 24.33880  -14.89566 -1.63325  1.000 39.76803  ?  41   GLY A C   1 
ATOM   315  O  O   . GLY A 1 41  ? 24.98530  -13.83702 -1.58548  1.000 36.15938  ?  41   GLY A O   1 
ATOM   316  N  N   . SER A 1 42  ? 24.77637  -16.03213 -1.09378  1.000 33.97767  ?  42   SER A N   1 
ATOM   317  C  CA  . SER A 1 42  ? 25.91926  -16.03658 -0.19250  1.000 35.21857  ?  42   SER A CA  1 
ATOM   318  C  C   . SER A 1 42  ? 27.22758  -15.71785 -0.91039  1.000 35.52195  ?  42   SER A C   1 
ATOM   319  O  O   . SER A 1 42  ? 28.17048  -15.21715 -0.28588  1.000 33.53608  ?  42   SER A O   1 
ATOM   320  C  CB  . SER A 1 42  ? 26.01083  -17.39582 0.49998   1.000 38.65487  ?  42   SER A CB  1 
ATOM   321  O  OG  . SER A 1 42  ? 26.02270  -18.40709 -0.48486  1.000 37.17303  ?  42   SER A OG  1 
ATOM   322  N  N   . LEU A 1 43  ? 27.31516  -15.99820 -2.20601  1.000 34.79132  ?  43   LEU A N   1 
ATOM   323  C  CA  . LEU A 1 43  ? 28.55071  -15.70332 -2.92327  1.000 34.57428  ?  43   LEU A CA  1 
ATOM   324  C  C   . LEU A 1 43  ? 28.89883  -14.21833 -2.84474  1.000 32.13197  ?  43   LEU A C   1 
ATOM   325  O  O   . LEU A 1 43  ? 30.07561  -13.85249 -2.75980  1.000 35.71799  ?  43   LEU A O   1 
ATOM   326  C  CB  . LEU A 1 43  ? 28.42641  -16.16300 -4.36967  1.000 33.37503  ?  43   LEU A CB  1 
ATOM   327  C  CG  . LEU A 1 43  ? 29.73677  -16.38886 -5.12487  1.000 40.38656  ?  43   LEU A CG  1 
ATOM   328  C  CD1 . LEU A 1 43  ? 30.66075  -17.30876 -4.37033  1.000 38.23188  ?  43   LEU A CD1 1 
ATOM   329  C  CD2 . LEU A 1 43  ? 29.40344  -16.95801 -6.50020  1.000 43.08995  ?  43   LEU A CD2 1 
ATOM   330  N  N   . PHE A 1 44  ? 27.89101  -13.34457 -2.85907  1.000 34.69533  ?  44   PHE A N   1 
ATOM   331  C  CA  . PHE A 1 44  ? 28.15863  -11.91889 -2.68286  1.000 29.72280  ?  44   PHE A CA  1 
ATOM   332  C  C   . PHE A 1 44  ? 28.81296  -11.64807 -1.32778  1.000 30.01066  ?  44   PHE A C   1 
ATOM   333  O  O   . PHE A 1 44  ? 29.77166  -10.86924 -1.22501  1.000 34.08959  ?  44   PHE A O   1 
ATOM   334  C  CB  . PHE A 1 44  ? 26.84947  -11.12732 -2.85215  1.000 28.37628  ?  44   PHE A CB  1 
ATOM   335  C  CG  . PHE A 1 44  ? 26.41457  -10.96745 -4.29861  1.000 29.19971  ?  44   PHE A CG  1 
ATOM   336  C  CD1 . PHE A 1 44  ? 25.65593  -11.93284 -4.93268  1.000 30.45203  ?  44   PHE A CD1 1 
ATOM   337  C  CD2 . PHE A 1 44  ? 26.78344  -9.84316  -5.02202  1.000 34.60291  ?  44   PHE A CD2 1 
ATOM   338  C  CE1 . PHE A 1 44  ? 25.26551  -11.78585 -6.27180  1.000 32.23232  ?  44   PHE A CE1 1 
ATOM   339  C  CE2 . PHE A 1 44  ? 26.40666  -9.68918  -6.34850  1.000 34.07873  ?  44   PHE A CE2 1 
ATOM   340  C  CZ  . PHE A 1 44  ? 25.64246  -10.66947 -6.97922  1.000 34.47009  ?  44   PHE A CZ  1 
ATOM   341  N  N   . ALA A 1 45  ? 28.31653  -12.28681 -0.27086  1.000 27.61315  ?  45   ALA A N   1 
ATOM   342  C  CA  . ALA A 1 45  ? 28.92932  -12.09683 1.03787   1.000 31.93933  ?  45   ALA A CA  1 
ATOM   343  C  C   . ALA A 1 45  ? 30.34295  -12.66459 1.06983   1.000 32.62040  ?  45   ALA A C   1 
ATOM   344  O  O   . ALA A 1 45  ? 31.24336  -12.06486 1.67723   1.000 31.76954  ?  45   ALA A O   1 
ATOM   345  C  CB  . ALA A 1 45  ? 28.06888  -12.73450 2.13209   1.000 31.28992  ?  45   ALA A CB  1 
ATOM   346  N  N   . GLU A 1 46  ? 30.55511  -13.81973 0.42332   1.000 31.71474  ?  46   GLU A N   1 
ATOM   347  C  CA  . GLU A 1 46  ? 31.88415  -14.42220 0.41571   1.000 33.17255  ?  46   GLU A CA  1 
ATOM   348  C  C   . GLU A 1 46  ? 32.88652  -13.48832 -0.23273  1.000 31.32395  ?  46   GLU A C   1 
ATOM   349  O  O   . GLU A 1 46  ? 33.95348  -13.21807 0.32744   1.000 29.04324  ?  46   GLU A O   1 
ATOM   350  C  CB  . GLU A 1 46  ? 31.88550  -15.76109 -0.32693  1.000 33.45844  ?  46   GLU A CB  1 
ATOM   351  C  CG  . GLU A 1 46  ? 33.32436  -16.26286 -0.59748  1.000 39.59765  ?  46   GLU A CG  1 
ATOM   352  C  CD  . GLU A 1 46  ? 33.40632  -17.65040 -1.25782  1.000 49.28621  ?  46   GLU A CD  1 
ATOM   353  O  OE1 . GLU A 1 46  ? 32.37484  -18.20074 -1.70395  1.000 48.27103  ?  46   GLU A OE1 1 
ATOM   354  O  OE2 . GLU A 1 46  ? 34.52083  -18.20961 -1.32414  1.000 57.82483  -1 46   GLU A OE2 1 
ATOM   355  N  N   . TYR A 1 47  ? 32.55794  -13.00599 -1.43313  1.000 32.05598  ?  47   TYR A N   1 
ATOM   356  C  CA  . TYR A 1 47  ? 33.40999  -12.04486 -2.11973  1.000 31.50347  ?  47   TYR A CA  1 
ATOM   357  C  C   . TYR A 1 47  ? 33.67054  -10.82958 -1.24883  1.000 29.59207  ?  47   TYR A C   1 
ATOM   358  O  O   . TYR A 1 47  ? 34.79246  -10.30380 -1.21667  1.000 30.43905  ?  47   TYR A O   1 
ATOM   359  C  CB  . TYR A 1 47  ? 32.75693  -11.60152 -3.43276  1.000 35.33886  ?  47   TYR A CB  1 
ATOM   360  C  CG  . TYR A 1 47  ? 32.83106  -12.57874 -4.59361  1.000 35.42301  ?  47   TYR A CG  1 
ATOM   361  C  CD1 . TYR A 1 47  ? 32.91843  -13.95839 -4.38633  1.000 38.09784  ?  47   TYR A CD1 1 
ATOM   362  C  CD2 . TYR A 1 47  ? 32.75941  -12.11990 -5.90129  1.000 33.89042  ?  47   TYR A CD2 1 
ATOM   363  C  CE1 . TYR A 1 47  ? 32.96697  -14.84180 -5.46037  1.000 42.76539  ?  47   TYR A CE1 1 
ATOM   364  C  CE2 . TYR A 1 47  ? 32.80031  -12.98212 -6.97378  1.000 41.34074  ?  47   TYR A CE2 1 
ATOM   365  C  CZ  . TYR A 1 47  ? 32.90781  -14.34143 -6.75145  1.000 45.91919  ?  47   TYR A CZ  1 
ATOM   366  O  OH  . TYR A 1 47  ? 32.93797  -15.18844 -7.82055  1.000 37.55746  ?  47   TYR A OH  1 
ATOM   367  N  N   . ALA A 1 48  ? 32.63293  -10.32930 -0.56937  1.000 34.90154  ?  48   ALA A N   1 
ATOM   368  C  CA  . ALA A 1 48  ? 32.85327  -9.13593  0.24688   1.000 34.80237  ?  48   ALA A CA  1 
ATOM   369  C  C   . ALA A 1 48  ? 33.80990  -9.44182  1.39915   1.000 32.10201  ?  48   ALA A C   1 
ATOM   370  O  O   . ALA A 1 48  ? 34.68164  -8.62685  1.72687   1.000 26.44880  ?  48   ALA A O   1 
ATOM   371  C  CB  . ALA A 1 48  ? 31.51892  -8.58357  0.75434   1.000 31.56608  ?  48   ALA A CB  1 
ATOM   372  N  N   . GLY A 1 49  ? 33.67900  -10.62183 2.01078   1.000 29.82410  ?  49   GLY A N   1 
ATOM   373  C  CA  . GLY A 1 49  ? 34.59748  -10.98032 3.08550   1.000 30.98445  ?  49   GLY A CA  1 
ATOM   374  C  C   . GLY A 1 49  ? 36.02273  -11.15825 2.58497   1.000 33.63255  ?  49   GLY A C   1 
ATOM   375  O  O   . GLY A 1 49  ? 36.98742  -10.75994 3.24505   1.000 30.16126  ?  49   GLY A O   1 
ATOM   376  N  N   . LEU A 1 50  ? 36.16674  -11.74578 1.40418   1.000 34.36329  ?  50   LEU A N   1 
ATOM   377  C  CA  . LEU A 1 50  ? 37.48027  -11.98563 0.83035   1.000 36.60950  ?  50   LEU A CA  1 
ATOM   378  C  C   . LEU A 1 50  ? 38.18377  -10.67916 0.49580   1.000 35.42159  ?  50   LEU A C   1 
ATOM   379  O  O   . LEU A 1 50  ? 39.39354  -10.55349 0.70993   1.000 31.29440  ?  50   LEU A O   1 
ATOM   380  C  CB  . LEU A 1 50  ? 37.34042  -12.84856 -0.41689  1.000 31.81453  ?  50   LEU A CB  1 
ATOM   381  C  CG  . LEU A 1 50  ? 38.59633  -13.64472 -0.72078  1.000 43.36284  ?  50   LEU A CG  1 
ATOM   382  C  CD1 . LEU A 1 50  ? 38.94297  -14.57369 0.44960   1.000 38.81076  ?  50   LEU A CD1 1 
ATOM   383  C  CD2 . LEU A 1 50  ? 38.39953  -14.42694 -2.00171  1.000 47.43265  ?  50   LEU A CD2 1 
ATOM   384  N  N   . LEU A 1 51  ? 37.43575  -9.70046  -0.02121  1.000 31.76825  ?  51   LEU A N   1 
ATOM   385  C  CA  . LEU A 1 51  ? 37.99843  -8.44360  -0.50821  1.000 34.50348  ?  51   LEU A CA  1 
ATOM   386  C  C   . LEU A 1 51  ? 38.09089  -7.34023  0.54202   1.000 35.93878  ?  51   LEU A C   1 
ATOM   387  O  O   . LEU A 1 51  ? 38.84145  -6.36851  0.32478   1.000 35.81332  ?  51   LEU A O   1 
ATOM   388  C  CB  . LEU A 1 51  ? 37.15728  -7.90484  -1.68014  1.000 31.80657  ?  51   LEU A CB  1 
ATOM   389  C  CG  . LEU A 1 51  ? 37.21704  -8.73816  -2.96837  1.000 38.66505  ?  51   LEU A CG  1 
ATOM   390  C  CD1 . LEU A 1 51  ? 36.38450  -8.07951  -4.04154  1.000 40.05970  ?  51   LEU A CD1 1 
ATOM   391  C  CD2 . LEU A 1 51  ? 38.65703  -8.94636  -3.46290  1.000 40.25651  ?  51   LEU A CD2 1 
ATOM   392  N  N   . HIS A 1 52  ? 37.36973  -7.45607  1.66569   1.000 30.16896  ?  52   HIS A N   1 
ATOM   393  C  CA  . HIS A 1 52  ? 37.18108  -6.29003  2.53329   1.000 27.80748  ?  52   HIS A CA  1 
ATOM   394  C  C   . HIS A 1 52  ? 38.51584  -5.70412  2.98910   1.000 32.21534  ?  52   HIS A C   1 
ATOM   395  O  O   . HIS A 1 52  ? 38.71269  -4.47995  2.91809   1.000 35.31628  ?  52   HIS A O   1 
ATOM   396  C  CB  . HIS A 1 52  ? 36.26062  -6.64912  3.71953   1.000 31.27031  ?  52   HIS A CB  1 
ATOM   397  C  CG  . HIS A 1 52  ? 36.95661  -7.28310  4.89438   1.000 32.86229  ?  52   HIS A CG  1 
ATOM   398  N  ND1 . HIS A 1 52  ? 37.40771  -8.58524  4.88167   1.000 29.56798  ?  52   HIS A ND1 1 
ATOM   399  C  CD2 . HIS A 1 52  ? 37.27277  -6.79017  6.11745   1.000 31.97119  ?  52   HIS A CD2 1 
ATOM   400  C  CE1 . HIS A 1 52  ? 37.97426  -8.86434  6.04299   1.000 33.39803  ?  52   HIS A CE1 1 
ATOM   401  N  NE2 . HIS A 1 52  ? 37.92388  -7.78736  6.80548   1.000 27.16836  ?  52   HIS A NE2 1 
ATOM   402  N  N   . ASP A 1 53  ? 39.48064  -6.55076  3.37936   1.000 31.99373  ?  53   ASP A N   1 
ATOM   403  C  CA  . ASP A 1 53  ? 40.77524  -6.06093  3.85364   1.000 32.56081  ?  53   ASP A CA  1 
ATOM   404  C  C   . ASP A 1 53  ? 41.87976  -6.17601  2.78898   1.000 31.86682  ?  53   ASP A C   1 
ATOM   405  O  O   . ASP A 1 53  ? 43.06638  -6.28387  3.13223   1.000 31.47557  ?  53   ASP A O   1 
ATOM   406  C  CB  . ASP A 1 53  ? 41.20618  -6.77841  5.14732   1.000 27.98660  ?  53   ASP A CB  1 
ATOM   407  C  CG  . ASP A 1 53  ? 40.53129  -6.21636  6.41810   1.000 34.54908  ?  53   ASP A CG  1 
ATOM   408  O  OD1 . ASP A 1 53  ? 39.92270  -5.11670  6.40044   1.000 30.72354  ?  53   ASP A OD1 1 
ATOM   409  O  OD2 . ASP A 1 53  ? 40.59858  -6.91305  7.46039   1.000 35.30074  -1 53   ASP A OD2 1 
ATOM   410  N  N   . LEU A 1 54  ? 41.53154  -6.10382  1.50081   1.000 29.24995  ?  54   LEU A N   1 
ATOM   411  C  CA  . LEU A 1 54  ? 42.56360  -6.19551  0.46425   1.000 31.00659  ?  54   LEU A CA  1 
ATOM   412  C  C   . LEU A 1 54  ? 43.58847  -5.07079  0.60111   1.000 35.97751  ?  54   LEU A C   1 
ATOM   413  O  O   . LEU A 1 54  ? 44.79590  -5.27870  0.38763   1.000 39.56896  ?  54   LEU A O   1 
ATOM   414  C  CB  . LEU A 1 54  ? 41.92903  -6.16838  -0.92663  1.000 30.80907  ?  54   LEU A CB  1 
ATOM   415  C  CG  . LEU A 1 54  ? 42.94556  -6.06990  -2.05920  1.000 38.62113  ?  54   LEU A CG  1 
ATOM   416  C  CD1 . LEU A 1 54  ? 43.74018  -7.39265  -2.13023  1.000 34.02268  ?  54   LEU A CD1 1 
ATOM   417  C  CD2 . LEU A 1 54  ? 42.30657  -5.70026  -3.41480  1.000 33.81328  ?  54   LEU A CD2 1 
ATOM   418  N  N   . GLY A 1 55  ? 43.13643  -3.88790  1.01511   1.000 29.83722  ?  55   GLY A N   1 
ATOM   419  C  CA  . GLY A 1 55  ? 44.03448  -2.76190  1.16208   1.000 35.50155  ?  55   GLY A CA  1 
ATOM   420  C  C   . GLY A 1 55  ? 45.08050  -2.90645  2.24621   1.000 38.85270  ?  55   GLY A C   1 
ATOM   421  O  O   . GLY A 1 55  ? 45.99180  -2.07412  2.31472   1.000 36.20821  ?  55   GLY A O   1 
ATOM   422  N  N   . LYS A 1 56  ? 44.97142  -3.90506  3.11591   1.000 34.10575  ?  56   LYS A N   1 
ATOM   423  C  CA  . LYS A 1 56  ? 46.04913  -4.03998  4.07788   1.000 38.06218  ?  56   LYS A CA  1 
ATOM   424  C  C   . LYS A 1 56  ? 47.29510  -4.66708  3.45534   1.000 39.23055  ?  56   LYS A C   1 
ATOM   425  O  O   . LYS A 1 56  ? 48.34180  -4.69160  4.11228   1.000 38.71756  ?  56   LYS A O   1 
ATOM   426  C  CB  . LYS A 1 56  ? 45.58894  -4.84023  5.30120   1.000 40.42820  ?  56   LYS A CB  1 
ATOM   427  C  CG  . LYS A 1 56  ? 44.56690  -4.11297  6.14787   1.000 35.99484  ?  56   LYS A CG  1 
ATOM   428  C  CD  . LYS A 1 56  ? 44.00280  -5.03955  7.25227   1.000 31.52049  ?  56   LYS A CD  1 
ATOM   429  C  CE  . LYS A 1 56  ? 43.06550  -4.26467  8.18522   1.000 27.26898  ?  56   LYS A CE  1 
ATOM   430  N  NZ  . LYS A 1 56  ? 42.20661  -5.14985  9.03558   1.000 32.98853  ?  56   LYS A NZ  1 
ATOM   431  N  N   . PHE A 1 57  ? 47.22381  -5.13015  2.19788   1.000 35.63181  ?  57   PHE A N   1 
ATOM   432  C  CA  . PHE A 1 57  ? 48.44683  -5.55239  1.51846   1.000 37.70896  ?  57   PHE A CA  1 
ATOM   433  C  C   . PHE A 1 57  ? 49.36289  -4.39982  1.13295   1.000 41.70100  ?  57   PHE A C   1 
ATOM   434  O  O   . PHE A 1 57  ? 50.47451  -4.66631  0.65348   1.000 36.09295  ?  57   PHE A O   1 
ATOM   435  C  CB  . PHE A 1 57  ? 48.13556  -6.35228  0.26579   1.000 39.02883  ?  57   PHE A CB  1 
ATOM   436  C  CG  . PHE A 1 57  ? 47.75721  -7.76575  0.54781   1.000 43.05661  ?  57   PHE A CG  1 
ATOM   437  C  CD1 . PHE A 1 57  ? 48.73228  -8.72227  0.76263   1.000 44.22890  ?  57   PHE A CD1 1 
ATOM   438  C  CD2 . PHE A 1 57  ? 46.41991  -8.14056  0.60504   1.000 37.02585  ?  57   PHE A CD2 1 
ATOM   439  C  CE1 . PHE A 1 57  ? 48.37801  -10.04275 1.02731   1.000 43.36435  ?  57   PHE A CE1 1 
ATOM   440  C  CE2 . PHE A 1 57  ? 46.06892  -9.45101  0.85760   1.000 42.26423  ?  57   PHE A CE2 1 
ATOM   441  C  CZ  . PHE A 1 57  ? 47.04974  -10.39332 1.07883   1.000 40.85709  ?  57   PHE A CZ  1 
ATOM   442  N  N   . GLN A 1 58  ? 48.93305  -3.14487  1.28661   1.000 35.01999  ?  58   GLN A N   1 
ATOM   443  C  CA  . GLN A 1 58  ? 49.85240  -2.04523  1.04133   1.000 38.06469  ?  58   GLN A CA  1 
ATOM   444  C  C   . GLN A 1 58  ? 51.03727  -2.16758  1.97089   1.000 38.17362  ?  58   GLN A C   1 
ATOM   445  O  O   . GLN A 1 58  ? 50.86489  -2.36647  3.17662   1.000 38.88162  ?  58   GLN A O   1 
ATOM   446  C  CB  . GLN A 1 58  ? 49.17559  -0.69229  1.26527   1.000 37.10728  ?  58   GLN A CB  1 
ATOM   447  C  CG  . GLN A 1 58  ? 48.03528  -0.42055  0.30870   1.000 39.23663  ?  58   GLN A CG  1 
ATOM   448  C  CD  . GLN A 1 58  ? 47.12871  0.66693   0.81978   1.000 41.34668  ?  58   GLN A CD  1 
ATOM   449  O  OE1 . GLN A 1 58  ? 47.34568  1.85071   0.53302   1.000 39.85607  ?  58   GLN A OE1 1 
ATOM   450  N  NE2 . GLN A 1 58  ? 46.11208  0.28086   1.60284   1.000 38.82670  ?  58   GLN A NE2 1 
ATOM   451  N  N   . GLU A 1 59  ? 52.24500  -2.03652  1.40626   1.000 39.99609  ?  59   GLU A N   1 
ATOM   452  C  CA  . GLU A 1 59  ? 53.44002  -1.96319  2.23950   1.000 41.00316  ?  59   GLU A CA  1 
ATOM   453  C  C   . GLU A 1 59  ? 53.32059  -0.85735  3.28532   1.000 43.32279  ?  59   GLU A C   1 
ATOM   454  O  O   . GLU A 1 59  ? 53.75309  -1.03638  4.43405   1.000 38.58418  ?  59   GLU A O   1 
ATOM   455  C  CB  . GLU A 1 59  ? 54.68404  -1.74294  1.37638   1.000 44.79777  ?  59   GLU A CB  1 
ATOM   456  C  CG  . GLU A 1 59  ? 55.92910  -1.33100  2.17168   1.000 50.31257  ?  59   GLU A CG  1 
ATOM   457  C  CD  . GLU A 1 59  ? 57.13942  -1.02677  1.27474   1.000 62.54994  ?  59   GLU A CD  1 
ATOM   458  O  OE1 . GLU A 1 59  ? 57.97816  -0.17599  1.65763   1.000 66.37099  ?  59   GLU A OE1 1 
ATOM   459  O  OE2 . GLU A 1 59  ? 57.24868  -1.63333  0.18293   1.000 69.08523  -1 59   GLU A OE2 1 
ATOM   460  N  N   . SER A 1 60  ? 52.72975  0.29213   2.92010   1.000 34.35215  ?  60   SER A N   1 
ATOM   461  C  CA  . SER A 1 60  ? 52.58417  1.34505   3.92396   1.000 37.81327  ?  60   SER A CA  1 
ATOM   462  C  C   . SER A 1 60  ? 51.76162  0.85523   5.11256   1.000 42.86566  ?  60   SER A C   1 
ATOM   463  O  O   . SER A 1 60  ? 52.07740  1.17418   6.27043   1.000 41.65884  ?  60   SER A O   1 
ATOM   464  C  CB  . SER A 1 60  ? 51.94763  2.59021   3.32125   1.000 41.88583  ?  60   SER A CB  1 
ATOM   465  O  OG  . SER A 1 60  ? 50.71773  2.28568   2.69473   1.000 40.86601  ?  60   SER A OG  1 
ATOM   466  N  N   . PHE A 1 61  ? 50.72122  0.04927   4.85861   1.000 37.28995  ?  61   PHE A N   1 
ATOM   467  C  CA  . PHE A 1 61  ? 49.92468  -0.44567  5.97861   1.000 40.37170  ?  61   PHE A CA  1 
ATOM   468  C  C   . PHE A 1 61  ? 50.75299  -1.34539  6.89017   1.000 38.76609  ?  61   PHE A C   1 
ATOM   469  O  O   . PHE A 1 61  ? 50.73918  -1.18229  8.11923   1.000 38.68002  ?  61   PHE A O   1 
ATOM   470  C  CB  . PHE A 1 61  ? 48.66897  -1.19482  5.50822   1.000 37.24102  ?  61   PHE A CB  1 
ATOM   471  C  CG  . PHE A 1 61  ? 47.80348  -1.66391  6.66758   1.000 34.27861  ?  61   PHE A CG  1 
ATOM   472  C  CD1 . PHE A 1 61  ? 46.87207  -0.81221  7.24619   1.000 34.56990  ?  61   PHE A CD1 1 
ATOM   473  C  CD2 . PHE A 1 61  ? 47.98353  -2.92529  7.22191   1.000 32.57248  ?  61   PHE A CD2 1 
ATOM   474  C  CE1 . PHE A 1 61  ? 46.09397  -1.22829  8.33567   1.000 40.03176  ?  61   PHE A CE1 1 
ATOM   475  C  CE2 . PHE A 1 61  ? 47.22389  -3.35449  8.28588   1.000 32.95523  ?  61   PHE A CE2 1 
ATOM   476  C  CZ  . PHE A 1 61  ? 46.27837  -2.51005  8.86206   1.000 35.38933  ?  61   PHE A CZ  1 
ATOM   477  N  N   . GLN A 1 62  ? 51.46099  -2.32454  6.31024   1.000 37.20187  ?  62   GLN A N   1 
ATOM   478  C  CA  . GLN A 1 62  ? 52.21986  -3.24887  7.14414   1.000 39.16603  ?  62   GLN A CA  1 
ATOM   479  C  C   . GLN A 1 62  ? 53.30210  -2.50806  7.91864   1.000 43.55921  ?  62   GLN A C   1 
ATOM   480  O  O   . GLN A 1 62  ? 53.54274  -2.78560  9.10625   1.000 47.68897  ?  62   GLN A O   1 
ATOM   481  C  CB  . GLN A 1 62  ? 52.79942  -4.36172  6.28102   1.000 39.88283  ?  62   GLN A CB  1 
ATOM   482  C  CG  . GLN A 1 62  ? 51.70524  -5.17172  5.57053   1.000 40.27869  ?  62   GLN A CG  1 
ATOM   483  C  CD  . GLN A 1 62  ? 50.98682  -6.13251  6.51162   1.000 43.47862  ?  62   GLN A CD  1 
ATOM   484  O  OE1 . GLN A 1 62  ? 51.54535  -6.56864  7.52569   1.000 41.36462  ?  62   GLN A OE1 1 
ATOM   485  N  NE2 . GLN A 1 62  ? 49.73641  -6.45083  6.19282   1.000 39.13504  ?  62   GLN A NE2 1 
ATOM   486  N  N   . LYS A 1 63  ? 53.92523  -1.52339  7.27212   1.000 40.29414  ?  63   LYS A N   1 
ATOM   487  C  CA  . LYS A 1 63  ? 54.92138  -0.70182  7.94525   1.000 46.15626  ?  63   LYS A CA  1 
ATOM   488  C  C   . LYS A 1 63  ? 54.30963  0.02533   9.13279   1.000 42.19916  ?  63   LYS A C   1 
ATOM   489  O  O   . LYS A 1 63  ? 54.90334  0.05957   10.22050  1.000 43.44918  ?  63   LYS A O   1 
ATOM   490  C  CB  . LYS A 1 63  ? 55.52576  0.28826   6.94891   1.000 43.78862  ?  63   LYS A CB  1 
ATOM   491  C  CG  . LYS A 1 63  ? 56.76202  -0.22058  6.26173   1.000 53.96773  ?  63   LYS A CG  1 
ATOM   492  C  CD  . LYS A 1 63  ? 57.21098  0.75743   5.18328   1.000 59.50866  ?  63   LYS A CD  1 
ATOM   493  C  CE  . LYS A 1 63  ? 58.65653  0.51784   4.75263   1.000 56.16534  ?  63   LYS A CE  1 
ATOM   494  N  NZ  . LYS A 1 63  ? 59.51894  1.71222   5.05754   1.000 64.59258  ?  63   LYS A NZ  1 
ATOM   495  N  N   . TYR A 1 64  ? 53.11268  0.59760   8.94664   1.000 42.78828  ?  64   TYR A N   1 
ATOM   496  C  CA  . TYR A 1 64  ? 52.43394  1.29179   10.04142  1.000 41.60194  ?  64   TYR A CA  1 
ATOM   497  C  C   . TYR A 1 64  ? 52.14441  0.34375   11.19791  1.000 40.74272  ?  64   TYR A C   1 
ATOM   498  O  O   . TYR A 1 64  ? 52.40946  0.65783   12.36045  1.000 40.91149  ?  64   TYR A O   1 
ATOM   499  C  CB  . TYR A 1 64  ? 51.13030  1.92204   9.53426   1.000 40.64958  ?  64   TYR A CB  1 
ATOM   500  C  CG  . TYR A 1 64  ? 50.39972  2.82928   10.52400  1.000 42.63089  ?  64   TYR A CG  1 
ATOM   501  C  CD1 . TYR A 1 64  ? 49.84593  2.33712   11.69801  1.000 38.72427  ?  64   TYR A CD1 1 
ATOM   502  C  CD2 . TYR A 1 64  ? 50.25320  4.18757   10.26543  1.000 46.97607  ?  64   TYR A CD2 1 
ATOM   503  C  CE1 . TYR A 1 64  ? 49.17379  3.18087   12.59595  1.000 41.29567  ?  64   TYR A CE1 1 
ATOM   504  C  CE2 . TYR A 1 64  ? 49.57875  5.02925   11.14998  1.000 42.06277  ?  64   TYR A CE2 1 
ATOM   505  C  CZ  . TYR A 1 64  ? 49.05301  4.52481   12.30870  1.000 40.58557  ?  64   TYR A CZ  1 
ATOM   506  O  OH  . TYR A 1 64  ? 48.40006  5.37628   13.16961  1.000 43.07753  ?  64   TYR A OH  1 
ATOM   507  N  N   . ILE A 1 65  ? 51.58027  -0.82587  10.89759  1.000 43.70712  ?  65   ILE A N   1 
ATOM   508  C  CA  . ILE A 1 65  ? 51.17435  -1.70937  11.97989  1.000 39.48200  ?  65   ILE A CA  1 
ATOM   509  C  C   . ILE A 1 65  ? 52.39110  -2.27968  12.70994  1.000 46.19723  ?  65   ILE A C   1 
ATOM   510  O  O   . ILE A 1 65  ? 52.26257  -2.72541  13.86009  1.000 46.23847  ?  65   ILE A O   1 
ATOM   511  C  CB  . ILE A 1 65  ? 50.23376  -2.81003  11.45043  1.000 35.38153  ?  65   ILE A CB  1 
ATOM   512  C  CG1 . ILE A 1 65  ? 49.30941  -3.27761  12.58229  1.000 33.26993  ?  65   ILE A CG1 1 
ATOM   513  C  CG2 . ILE A 1 65  ? 51.02857  -3.93756  10.79206  1.000 36.30657  ?  65   ILE A CG2 1 
ATOM   514  C  CD1 . ILE A 1 65  ? 48.34573  -4.36412  12.18804  1.000 35.62576  ?  65   ILE A CD1 1 
ATOM   515  N  N   . ARG A 1 66  ? 53.57906  -2.25240  12.08649  1.000 42.62806  ?  66   ARG A N   1 
ATOM   516  C  CA  . ARG A 1 66  ? 54.78434  -2.70833  12.77584  1.000 47.09617  ?  66   ARG A CA  1 
ATOM   517  C  C   . ARG A 1 66  ? 55.61089  -1.60936  13.44525  1.000 45.02659  ?  66   ARG A C   1 
ATOM   518  O  O   . ARG A 1 66  ? 56.39629  -1.93628  14.34169  1.000 46.09879  ?  66   ARG A O   1 
ATOM   519  C  CB  . ARG A 1 66  ? 55.68480  -3.48634  11.80961  1.000 43.56662  ?  66   ARG A CB  1 
ATOM   520  C  CG  . ARG A 1 66  ? 55.08773  -4.82470  11.42171  1.000 51.60349  ?  66   ARG A CG  1 
ATOM   521  C  CD  . ARG A 1 66  ? 56.09732  -5.80182  10.89283  1.000 46.24723  ?  66   ARG A CD  1 
ATOM   522  N  NE  . ARG A 1 66  ? 55.53284  -6.58589  9.80192   1.000 53.57173  ?  66   ARG A NE  1 
ATOM   523  C  CZ  . ARG A 1 66  ? 54.71796  -7.62550  9.95623   1.000 61.02735  ?  66   ARG A CZ  1 
ATOM   524  N  NH1 . ARG A 1 66  ? 54.34291  -8.04404  11.15783  1.000 62.66492  ?  66   ARG A NH1 1 
ATOM   525  N  NH2 . ARG A 1 66  ? 54.26714  -8.26189  8.87775   1.000 52.41601  ?  66   ARG A NH2 1 
ATOM   526  N  N   . ASN A 1 67  ? 55.46640  -0.32940  13.05677  1.000 45.05154  ?  67   ASN A N   1 
ATOM   527  C  CA  . ASN A 1 67  ? 56.40396  0.71979   13.49039  1.000 48.54489  ?  67   ASN A CA  1 
ATOM   528  C  C   . ASN A 1 67  ? 55.80412  1.84928   14.31212  1.000 45.40840  ?  67   ASN A C   1 
ATOM   529  O  O   . ASN A 1 67  ? 56.55804  2.70315   14.79661  1.000 49.48737  ?  67   ASN A O   1 
ATOM   530  C  CB  . ASN A 1 67  ? 57.09574  1.38509   12.28509  1.000 43.00523  ?  67   ASN A CB  1 
ATOM   531  C  CG  . ASN A 1 67  ? 58.01354  0.45280   11.55173  1.000 44.30244  ?  67   ASN A CG  1 
ATOM   532  O  OD1 . ASN A 1 67  ? 58.51531  -0.51414  12.12011  1.000 52.01768  ?  67   ASN A OD1 1 
ATOM   533  N  ND2 . ASN A 1 67  ? 58.24090  0.73322   10.27207  1.000 46.44599  ?  67   ASN A ND2 1 
ATOM   534  N  N   . ALA A 1 68  ? 54.49526  1.92729   14.44302  1.000 42.29888  ?  68   ALA A N   1 
ATOM   535  C  CA  . ALA A 1 68  ? 53.91301  3.07897   15.10721  1.000 44.29487  ?  68   ALA A CA  1 
ATOM   536  C  C   . ALA A 1 68  ? 53.92029  2.85797   16.61466  1.000 46.61199  ?  68   ALA A C   1 
ATOM   537  O  O   . ALA A 1 68  ? 54.37411  1.82225   17.11885  1.000 43.80948  ?  68   ALA A O   1 
ATOM   538  C  CB  . ALA A 1 68  ? 52.50074  3.33431   14.57833  1.000 48.43590  ?  68   ALA A CB  1 
ATOM   539  N  N   . SER A 1 69  ? 53.40025  3.84244   17.34373  1.000 41.79259  ?  69   SER A N   1 
ATOM   540  C  CA  . SER A 1 69  ? 53.25890  3.70991   18.78425  1.000 47.89382  ?  69   SER A CA  1 
ATOM   541  C  C   . SER A 1 69  ? 52.38744  2.49709   19.12960  1.000 46.51262  ?  69   SER A C   1 
ATOM   542  O  O   . SER A 1 69  ? 51.71259  1.92098   18.27644  1.000 51.23501  ?  69   SER A O   1 
ATOM   543  C  CB  . SER A 1 69  ? 52.64655  4.97793   19.36550  1.000 52.85118  ?  69   SER A CB  1 
ATOM   544  O  OG  . SER A 1 69  ? 51.23880  4.83815   19.43526  1.000 51.42635  ?  69   SER A OG  1 
ATOM   545  N  N   . GLY A 1 70  ? 52.40888  2.10954   20.40646  1.000 48.45346  ?  70   GLY A N   1 
ATOM   546  C  CA  . GLY A 1 70  ? 51.60924  0.96728   20.83671  1.000 46.62199  ?  70   GLY A CA  1 
ATOM   547  C  C   . GLY A 1 70  ? 50.12120  1.15925   20.58557  1.000 50.52735  ?  70   GLY A C   1 
ATOM   548  O  O   . GLY A 1 70  ? 49.44220  0.27441   20.05119  1.000 50.41369  ?  70   GLY A O   1 
ATOM   549  N  N   . PHE A 1 71  ? 49.59857  2.32713   20.95657  1.000 47.17091  ?  71   PHE A N   1 
ATOM   550  C  CA  . PHE A 1 71  ? 48.18153  2.62358   20.76490  1.000 47.76908  ?  71   PHE A CA  1 
ATOM   551  C  C   . PHE A 1 71  ? 47.81052  2.69952   19.28374  1.000 50.42636  ?  71   PHE A C   1 
ATOM   552  O  O   . PHE A 1 71  ? 46.78849  2.14065   18.86189  1.000 47.45966  ?  71   PHE A O   1 
ATOM   553  C  CB  . PHE A 1 71  ? 47.83355  3.92661   21.47414  1.000 40.70898  ?  71   PHE A CB  1 
ATOM   554  C  CG  . PHE A 1 71  ? 46.42745  4.37916   21.25076  1.000 47.03564  ?  71   PHE A CG  1 
ATOM   555  C  CD1 . PHE A 1 71  ? 45.40355  3.88637   22.03341  1.000 48.48098  ?  71   PHE A CD1 1 
ATOM   556  C  CD2 . PHE A 1 71  ? 46.12873  5.29891   20.25933  1.000 45.39461  ?  71   PHE A CD2 1 
ATOM   557  C  CE1 . PHE A 1 71  ? 44.11032  4.29055   21.83782  1.000 50.82906  ?  71   PHE A CE1 1 
ATOM   558  C  CE2 . PHE A 1 71  ? 44.83305  5.71621   20.05833  1.000 52.01108  ?  71   PHE A CE2 1 
ATOM   559  C  CZ  . PHE A 1 71  ? 43.81726  5.20639   20.84936  1.000 50.15933  ?  71   PHE A CZ  1 
ATOM   560  N  N   . GLU A 1 72  ? 48.62047  3.39434   18.47636  1.000 48.34480  ?  72   GLU A N   1 
ATOM   561  C  CA  . GLU A 1 72  ? 48.34240  3.45484   17.04353  1.000 46.88189  ?  72   GLU A CA  1 
ATOM   562  C  C   . GLU A 1 72  ? 48.51343  2.09677   16.37484  1.000 46.79455  ?  72   GLU A C   1 
ATOM   563  O  O   . GLU A 1 72  ? 47.82455  1.80064   15.39075  1.000 46.40554  ?  72   GLU A O   1 
ATOM   564  C  CB  . GLU A 1 72  ? 49.23262  4.48001   16.33345  1.000 48.64310  ?  72   GLU A CB  1 
ATOM   565  C  CG  . GLU A 1 72  ? 49.59721  5.71648   17.10966  1.000 52.45675  ?  72   GLU A CG  1 
ATOM   566  C  CD  . GLU A 1 72  ? 50.66187  6.52458   16.38178  1.000 58.56044  ?  72   GLU A CD  1 
ATOM   567  O  OE1 . GLU A 1 72  ? 51.80990  6.02888   16.21295  1.000 59.70848  ?  72   GLU A OE1 1 
ATOM   568  O  OE2 . GLU A 1 72  ? 50.33622  7.65039   15.95025  1.000 67.16550  -1 72   GLU A OE2 1 
ATOM   569  N  N   . LYS A 1 73  ? 49.46758  1.28404   16.84182  1.000 43.85785  ?  73   LYS A N   1 
ATOM   570  C  CA  . LYS A 1 73  ? 49.59451  -0.05083  16.26311  1.000 46.75423  ?  73   LYS A CA  1 
ATOM   571  C  C   . LYS A 1 73  ? 48.36173  -0.88785  16.58336  1.000 45.40437  ?  73   LYS A C   1 
ATOM   572  O  O   . LYS A 1 73  ? 47.81040  -1.55823  15.69964  1.000 42.50106  ?  73   LYS A O   1 
ATOM   573  C  CB  . LYS A 1 73  ? 50.88412  -0.73516  16.74006  1.000 45.29068  ?  73   LYS A CB  1 
ATOM   574  C  CG  . LYS A 1 73  ? 52.16877  -0.21191  16.02436  1.000 48.17081  ?  73   LYS A CG  1 
ATOM   575  C  CD  . LYS A 1 73  ? 53.43937  -1.07178  16.30762  1.000 43.61011  ?  73   LYS A CD  1 
ATOM   576  C  CE  . LYS A 1 73  ? 53.68291  -1.28364  17.81836  1.000 46.91693  ?  73   LYS A CE  1 
ATOM   577  N  NZ  . LYS A 1 73  ? 55.13595  -1.40220  18.19974  1.000 46.02253  ?  73   LYS A NZ  1 
ATOM   578  N  N   . GLU A 1 74  ? 47.87765  -0.81369  17.82314  1.000 42.54083  ?  74   GLU A N   1 
ATOM   579  C  CA  . GLU A 1 74  ? 46.66368  -1.54177  18.17938  1.000 47.59409  ?  74   GLU A CA  1 
ATOM   580  C  C   . GLU A 1 74  ? 45.42227  -1.02171  17.45953  1.000 45.08397  ?  74   GLU A C   1 
ATOM   581  O  O   . GLU A 1 74  ? 44.43828  -1.76104  17.34024  1.000 42.46866  ?  74   GLU A O   1 
ATOM   582  C  CB  . GLU A 1 74  ? 46.43414  -1.47937  19.68617  1.000 47.03042  ?  74   GLU A CB  1 
ATOM   583  C  CG  . GLU A 1 74  ? 47.01092  -2.66740  20.41571  1.000 51.77552  ?  74   GLU A CG  1 
ATOM   584  C  CD  . GLU A 1 74  ? 46.75021  -2.60715  21.90162  1.000 54.30155  ?  74   GLU A CD  1 
ATOM   585  O  OE1 . GLU A 1 74  ? 46.63007  -1.46757  22.44117  1.000 50.90912  ?  74   GLU A OE1 1 
ATOM   586  O  OE2 . GLU A 1 74  ? 46.61370  -3.70714  22.49786  1.000 48.22034  -1 74   GLU A OE2 1 
ATOM   587  N  N   . ASN A 1 75  ? 45.43571  0.23084   16.99264  1.000 40.35877  ?  75   ASN A N   1 
ATOM   588  C  CA  . ASN A 1 75  ? 44.28344  0.80756   16.31281  1.000 37.79085  ?  75   ASN A CA  1 
ATOM   589  C  C   . ASN A 1 75  ? 44.58888  1.14294   14.86236  1.000 41.10881  ?  75   ASN A C   1 
ATOM   590  O  O   . ASN A 1 75  ? 43.92356  2.00284   14.27175  1.000 41.45685  ?  75   ASN A O   1 
ATOM   591  C  CB  . ASN A 1 75  ? 43.79295  2.04647   17.05511  1.000 36.21999  ?  75   ASN A CB  1 
ATOM   592  C  CG  . ASN A 1 75  ? 43.27104  1.71052   18.42762  1.000 42.37467  ?  75   ASN A CG  1 
ATOM   593  O  OD1 . ASN A 1 75  ? 42.21213  1.10557   18.56240  1.000 39.95374  ?  75   ASN A OD1 1 
ATOM   594  N  ND2 . ASN A 1 75  ? 44.02409  2.08474   19.46756  1.000 44.87627  ?  75   ASN A ND2 1 
ATOM   595  N  N   . ALA A 1 76  ? 45.58104  0.47664   14.27286  1.000 38.20991  ?  76   ALA A N   1 
ATOM   596  C  CA  . ALA A 1 76  ? 45.99837  0.81470   12.92156  1.000 40.47126  ?  76   ALA A CA  1 
ATOM   597  C  C   . ALA A 1 76  ? 44.94059  0.47515   11.86796  1.000 41.68682  ?  76   ALA A C   1 
ATOM   598  O  O   . ALA A 1 76  ? 44.97719  1.02385   10.76203  1.000 41.71133  ?  76   ALA A O   1 
ATOM   599  C  CB  . ALA A 1 76  ? 47.31321  0.10317   12.60512  1.000 40.42243  ?  76   ALA A CB  1 
ATOM   600  N  N   . HIS A 1 77  ? 44.02394  -0.43866  12.15711  1.000 39.81654  ?  77   HIS A N   1 
ATOM   601  C  CA  . HIS A 1 77  ? 42.98905  -0.76833  11.19251  1.000 38.32435  ?  77   HIS A CA  1 
ATOM   602  C  C   . HIS A 1 77  ? 41.77815  0.16522   11.26866  1.000 37.45506  ?  77   HIS A C   1 
ATOM   603  O  O   . HIS A 1 77  ? 40.91883  0.10027   10.38908  1.000 38.36440  ?  77   HIS A O   1 
ATOM   604  C  CB  . HIS A 1 77  ? 42.53591  -2.21486  11.38674  1.000 35.74075  ?  77   HIS A CB  1 
ATOM   605  C  CG  . HIS A 1 77  ? 42.13193  -2.53217  12.79746  1.000 38.24514  ?  77   HIS A CG  1 
ATOM   606  N  ND1 . HIS A 1 77  ? 42.97946  -2.36817  13.87058  1.000 38.08887  ?  77   HIS A ND1 1 
ATOM   607  C  CD2 . HIS A 1 77  ? 40.96188  -2.97751  13.31283  1.000 36.76333  ?  77   HIS A CD2 1 
ATOM   608  C  CE1 . HIS A 1 77  ? 42.35446  -2.70555  14.98602  1.000 34.54968  ?  77   HIS A CE1 1 
ATOM   609  N  NE2 . HIS A 1 77  ? 41.12962  -3.07967  14.67440  1.000 35.42147  ?  77   HIS A NE2 1 
ATOM   610  N  N   . LEU A 1 78  ? 41.68096  1.02398   12.28604  1.000 37.63960  ?  78   LEU A N   1 
ATOM   611  C  CA  . LEU A 1 78  ? 40.53434  1.93272   12.41379  1.000 41.10943  ?  78   LEU A CA  1 
ATOM   612  C  C   . LEU A 1 78  ? 40.77221  3.17468   11.55880  1.000 40.62037  ?  78   LEU A C   1 
ATOM   613  O  O   . LEU A 1 78  ? 41.19368  4.21866   12.05771  1.000 43.10257  ?  78   LEU A O   1 
ATOM   614  C  CB  . LEU A 1 78  ? 40.28896  2.30140   13.87521  1.000 37.63371  ?  78   LEU A CB  1 
ATOM   615  C  CG  . LEU A 1 78  ? 39.56877  1.26267   14.74719  1.000 41.19104  ?  78   LEU A CG  1 
ATOM   616  C  CD1 . LEU A 1 78  ? 40.43715  0.02581   14.94482  1.000 36.10855  ?  78   LEU A CD1 1 
ATOM   617  C  CD2 . LEU A 1 78  ? 39.18051  1.83525   16.10215  1.000 39.44960  ?  78   LEU A CD2 1 
ATOM   618  N  N   . GLU A 1 79  ? 40.45035  3.06968   10.25378  1.000 38.58936  ?  79   GLU A N   1 
ATOM   619  C  CA  . GLU A 1 79  ? 40.68318  4.16669   9.30375   1.000 43.64176  ?  79   GLU A CA  1 
ATOM   620  C  C   . GLU A 1 79  ? 39.88938  5.43873   9.63416   1.000 48.07769  ?  79   GLU A C   1 
ATOM   621  O  O   . GLU A 1 79  ? 40.29892  6.52837   9.20896   1.000 47.57359  ?  79   GLU A O   1 
ATOM   622  C  CB  . GLU A 1 79  ? 40.37814  3.72587   7.85039   1.000 41.99870  ?  79   GLU A CB  1 
ATOM   623  C  CG  . GLU A 1 79  ? 39.31458  2.59433   7.67423   1.000 44.87410  ?  79   GLU A CG  1 
ATOM   624  C  CD  . GLU A 1 79  ? 39.02526  2.19622   6.20066   1.000 40.39443  ?  79   GLU A CD  1 
ATOM   625  O  OE1 . GLU A 1 79  ? 37.84847  2.22795   5.77780   1.000 39.04862  ?  79   GLU A OE1 1 
ATOM   626  O  OE2 . GLU A 1 79  ? 39.96333  1.85565   5.46024   1.000 39.19252  -1 79   GLU A OE2 1 
ATOM   627  N  N   . ASP A 1 80  ? 38.80675  5.33270   10.40865  1.000 48.37114  ?  80   ASP A N   1 
ATOM   628  C  CA  . ASP A 1 80  ? 37.93741  6.46383   10.81714  1.000 57.96831  ?  80   ASP A CA  1 
ATOM   629  C  C   . ASP A 1 80  ? 37.36887  7.23483   9.62764   1.000 68.29611  ?  80   ASP A C   1 
ATOM   630  O  O   . ASP A 1 80  ? 37.51500  8.45876   9.54263   1.000 69.32900  ?  80   ASP A O   1 
ATOM   631  C  CB  . ASP A 1 80  ? 38.66077  7.46543   11.73606  1.000 56.20457  ?  80   ASP A CB  1 
ATOM   632  C  CG  . ASP A 1 80  ? 39.00768  6.88289   13.10667  1.000 67.87401  ?  80   ASP A CG  1 
ATOM   633  O  OD1 . ASP A 1 80  ? 39.08306  5.63871   13.22644  1.000 63.98084  ?  80   ASP A OD1 1 
ATOM   634  O  OD2 . ASP A 1 80  ? 39.21566  7.67405   14.06109  1.000 73.12990  -1 80   ASP A OD2 1 
ATOM   635  N  N   . ARG A 1 87  ? 47.82897  10.45197  10.48267  1.000 60.56861  ?  87   ARG A N   1 
ATOM   636  C  CA  . ARG A 1 87  ? 46.69543  9.89501   9.75587   1.000 58.25916  ?  87   ARG A CA  1 
ATOM   637  C  C   . ARG A 1 87  ? 46.88233  8.39590   9.58202   1.000 52.89085  ?  87   ARG A C   1 
ATOM   638  O  O   . ARG A 1 87  ? 48.00230  7.91175   9.40569   1.000 50.65498  ?  87   ARG A O   1 
ATOM   639  C  CB  . ARG A 1 87  ? 46.52763  10.57348  8.38289   1.000 59.56438  ?  87   ARG A CB  1 
ATOM   640  C  CG  . ARG A 1 87  ? 45.10668  10.49042  7.78741   1.000 65.95931  ?  87   ARG A CG  1 
ATOM   641  C  CD  . ARG A 1 87  ? 44.82136  11.61071  6.77048   1.000 65.95027  ?  87   ARG A CD  1 
ATOM   642  N  NE  . ARG A 1 87  ? 43.87553  12.59305  7.29547   1.000 74.57677  ?  87   ARG A NE  1 
ATOM   643  C  CZ  . ARG A 1 87  ? 43.39986  13.63359  6.61795   1.000 78.51666  ?  87   ARG A CZ  1 
ATOM   644  N  NH1 . ARG A 1 87  ? 43.74521  13.86209  5.35812   1.000 68.94847  ?  87   ARG A NH1 1 
ATOM   645  N  NH2 . ARG A 1 87  ? 42.54364  14.46024  7.21576   1.000 76.78556  ?  87   ARG A NH2 1 
ATOM   646  N  N   . LYS A 1 88  ? 45.77902  7.66239   9.63972   1.000 46.50772  ?  88   LYS A N   1 
ATOM   647  C  CA  . LYS A 1 88  ? 45.80975  6.24515   9.33839   1.000 48.56400  ?  88   LYS A CA  1 
ATOM   648  C  C   . LYS A 1 88  ? 45.96701  6.03062   7.84074   1.000 50.45412  ?  88   LYS A C   1 
ATOM   649  O  O   . LYS A 1 88  ? 45.71784  6.91921   7.02377   1.000 53.32634  ?  88   LYS A O   1 
ATOM   650  C  CB  . LYS A 1 88  ? 44.54396  5.55881   9.83602   1.000 45.33246  ?  88   LYS A CB  1 
ATOM   651  C  CG  . LYS A 1 88  ? 44.14415  5.97475   11.24585  1.000 49.29160  ?  88   LYS A CG  1 
ATOM   652  C  CD  . LYS A 1 88  ? 44.85586  5.13423   12.28858  1.000 45.92875  ?  88   LYS A CD  1 
ATOM   653  C  CE  . LYS A 1 88  ? 44.40886  5.48675   13.71099  1.000 50.27460  ?  88   LYS A CE  1 
ATOM   654  N  NZ  . LYS A 1 88  ? 42.93828  5.43121   13.91944  1.000 54.07939  ?  88   LYS A NZ  1 
ATOM   655  N  N   . ILE A 1 89  ? 46.39533  4.82761   7.47363   1.000 43.57158  ?  89   ILE A N   1 
ATOM   656  C  CA  . ILE A 1 89  ? 46.49949  4.43503   6.07759   1.000 48.02667  ?  89   ILE A CA  1 
ATOM   657  C  C   . ILE A 1 89  ? 45.15985  3.80851   5.68277   1.000 52.40336  ?  89   ILE A C   1 
ATOM   658  O  O   . ILE A 1 89  ? 44.81286  2.74163   6.22212   1.000 48.22327  ?  89   ILE A O   1 
ATOM   659  C  CB  . ILE A 1 89  ? 47.67150  3.47638   5.84089   1.000 47.98236  ?  89   ILE A CB  1 
ATOM   660  C  CG1 . ILE A 1 89  ? 48.96701  4.24265   6.03352   1.000 48.19846  ?  89   ILE A CG1 1 
ATOM   661  C  CG2 . ILE A 1 89  ? 47.64893  2.94638   4.43536   1.000 44.78565  ?  89   ILE A CG2 1 
ATOM   662  C  CD1 . ILE A 1 89  ? 50.06689  3.38257   6.43905   1.000 51.21621  ?  89   ILE A CD1 1 
ATOM   663  N  N   . PRO A 1 90  ? 44.37938  4.44206   4.81008   1.000 51.93735  ?  90   PRO A N   1 
ATOM   664  C  CA  . PRO A 1 90  ? 43.10551  3.85058   4.39776   1.000 44.12638  ?  90   PRO A CA  1 
ATOM   665  C  C   . PRO A 1 90  ? 43.34358  2.51742   3.72536   1.000 42.87795  ?  90   PRO A C   1 
ATOM   666  O  O   . PRO A 1 90  ? 44.31126  2.34479   2.97310   1.000 42.32039  ?  90   PRO A O   1 
ATOM   667  C  CB  . PRO A 1 90  ? 42.51912  4.88100   3.43217   1.000 48.90796  ?  90   PRO A CB  1 
ATOM   668  C  CG  . PRO A 1 90  ? 43.40508  6.08481   3.48601   1.000 57.06789  ?  90   PRO A CG  1 
ATOM   669  C  CD  . PRO A 1 90  ? 44.67653  5.73173   4.16447   1.000 52.82149  ?  90   PRO A CD  1 
ATOM   670  N  N   . HIS A 1 91  ? 42.44624  1.56776   4.01837   1.000 36.36109  ?  91   HIS A N   1 
ATOM   671  C  CA  . HIS A 1 91  ? 42.54163  0.23889   3.43957   1.000 36.71610  ?  91   HIS A CA  1 
ATOM   672  C  C   . HIS A 1 91  ? 41.21887  -0.31602  2.91003   1.000 36.16176  ?  91   HIS A C   1 
ATOM   673  O  O   . HIS A 1 91  ? 41.25426  -1.28377  2.14439   1.000 33.95987  ?  91   HIS A O   1 
ATOM   674  C  CB  . HIS A 1 91  ? 43.12339  -0.73559  4.47747   1.000 37.09077  ?  91   HIS A CB  1 
ATOM   675  C  CG  . HIS A 1 91  ? 42.16142  -1.07518  5.57507   1.000 35.37206  ?  91   HIS A CG  1 
ATOM   676  N  ND1 . HIS A 1 91  ? 42.07896  -0.35364  6.74758   1.000 35.42651  ?  91   HIS A ND1 1 
ATOM   677  C  CD2 . HIS A 1 91  ? 41.21378  -2.03705  5.66022   1.000 35.89600  ?  91   HIS A CD2 1 
ATOM   678  C  CE1 . HIS A 1 91  ? 41.12847  -0.86184  7.51125   1.000 29.83492  ?  91   HIS A CE1 1 
ATOM   679  N  NE2 . HIS A 1 91  ? 40.60109  -1.89622  6.88163   1.000 37.78781  ?  91   HIS A NE2 1 
ATOM   680  N  N   . SER A 1 92  ? 40.05622  0.26783   3.24729   1.000 37.88376  ?  92   SER A N   1 
ATOM   681  C  CA  . SER A 1 92  ? 38.78884  -0.35576  2.87003   1.000 35.99279  ?  92   SER A CA  1 
ATOM   682  C  C   . SER A 1 92  ? 38.45974  -0.18072  1.40250   1.000 37.00302  ?  92   SER A C   1 
ATOM   683  O  O   . SER A 1 92  ? 37.68800  -0.97233  0.85583   1.000 33.74662  ?  92   SER A O   1 
ATOM   684  C  CB  . SER A 1 92  ? 37.61699  0.19195   3.69831   1.000 37.63773  ?  92   SER A CB  1 
ATOM   685  O  OG  . SER A 1 92  ? 37.45445  1.61263   3.58557   1.000 33.39540  ?  92   SER A OG  1 
ATOM   686  N  N   . THR A 1 93  ? 39.01970  0.81667   0.73829   1.000 35.84504  ?  93   THR A N   1 
ATOM   687  C  CA  . THR A 1 93  ? 38.47902  1.09167   -0.57870  1.000 36.80636  ?  93   THR A CA  1 
ATOM   688  C  C   . THR A 1 93  ? 39.24616  0.40740   -1.69568  1.000 31.14485  ?  93   THR A C   1 
ATOM   689  O  O   . THR A 1 93  ? 38.72219  0.33662   -2.81658  1.000 29.19815  ?  93   THR A O   1 
ATOM   690  C  CB  . THR A 1 93  ? 38.36258  2.61619   -0.76919  1.000 39.52708  ?  93   THR A CB  1 
ATOM   691  O  OG1 . THR A 1 93  ? 38.23873  2.95232   -2.14971  1.000 38.92703  ?  93   THR A OG1 1 
ATOM   692  C  CG2 . THR A 1 93  ? 39.49030  3.32533   -0.12802  1.000 35.96527  ?  93   THR A CG2 1 
ATOM   693  N  N   . ALA A 1 94  ? 40.41256  -0.18733  -1.39437  1.000 30.67805  ?  94   ALA A N   1 
ATOM   694  C  CA  . ALA A 1 94  ? 41.12071  -0.97603  -2.39602  1.000 35.52284  ?  94   ALA A CA  1 
ATOM   695  C  C   . ALA A 1 94  ? 40.26098  -2.12986  -2.90881  1.000 33.50153  ?  94   ALA A C   1 
ATOM   696  O  O   . ALA A 1 94  ? 40.13834  -2.33245  -4.12556  1.000 36.08308  ?  94   ALA A O   1 
ATOM   697  C  CB  . ALA A 1 94  ? 42.44418  -1.50293  -1.83244  1.000 35.87763  ?  94   ALA A CB  1 
ATOM   698  N  N   . GLY A 1 95  ? 39.66512  -2.90438  -1.99802  1.000 35.14907  ?  95   GLY A N   1 
ATOM   699  C  CA  . GLY A 1 95  ? 38.85977  -4.04379  -2.42270  1.000 32.72788  ?  95   GLY A CA  1 
ATOM   700  C  C   . GLY A 1 95  ? 37.59317  -3.62100  -3.14287  1.000 36.27573  ?  95   GLY A C   1 
ATOM   701  O  O   . GLY A 1 95  ? 37.11937  -4.31976  -4.05141  1.000 34.55065  ?  95   GLY A O   1 
ATOM   702  N  N   . ALA A 1 96  ? 37.03593  -2.46928  -2.76006  1.000 26.96614  ?  96   ALA A N   1 
ATOM   703  C  CA  . ALA A 1 96  ? 35.89300  -1.91917  -3.48030  1.000 32.38538  ?  96   ALA A CA  1 
ATOM   704  C  C   . ALA A 1 96  ? 36.26856  -1.62141  -4.92846  1.000 34.62969  ?  96   ALA A C   1 
ATOM   705  O  O   . ALA A 1 96  ? 35.57078  -2.03216  -5.87055  1.000 35.21204  ?  96   ALA A O   1 
ATOM   706  C  CB  . ALA A 1 96  ? 35.39324  -0.65149  -2.76203  1.000 29.01503  ?  96   ALA A CB  1 
ATOM   707  N  N   . LYS A 1 97  ? 37.39276  -0.92052  -5.12052  1.000 36.16457  ?  97   LYS A N   1 
ATOM   708  C  CA  . LYS A 1 97  ? 37.82399  -0.57779  -6.46998  1.000 37.21158  ?  97   LYS A CA  1 
ATOM   709  C  C   . LYS A 1 97  ? 38.11701  -1.83128  -7.27974  1.000 36.80331  ?  97   LYS A C   1 
ATOM   710  O  O   . LYS A 1 97  ? 37.76921  -1.91619  -8.46615  1.000 37.43016  ?  97   LYS A O   1 
ATOM   711  C  CB  . LYS A 1 97  ? 39.05649  0.32953   -6.41235  1.000 40.28314  ?  97   LYS A CB  1 
ATOM   712  C  CG  . LYS A 1 97  ? 39.48544  0.84387   -7.79844  1.000 40.02907  ?  97   LYS A CG  1 
ATOM   713  C  CD  . LYS A 1 97  ? 38.57269  1.97733   -8.25401  1.000 39.83311  ?  97   LYS A CD  1 
ATOM   714  C  CE  . LYS A 1 97  ? 39.17936  2.79434   -9.37935  1.000 41.79996  ?  97   LYS A CE  1 
ATOM   715  N  NZ  . LYS A 1 97  ? 38.22911  3.87246   -9.75430  1.000 46.32012  ?  97   LYS A NZ  1 
ATOM   716  N  N   . TYR A 1 98  ? 38.76194  -2.81618  -6.64904  1.000 37.44577  ?  98   TYR A N   1 
ATOM   717  C  CA  . TYR A 1 98  ? 39.05021  -4.06774  -7.33458  1.000 35.48054  ?  98   TYR A CA  1 
ATOM   718  C  C   . TYR A 1 98  ? 37.75956  -4.74162  -7.81231  1.000 35.85129  ?  98   TYR A C   1 
ATOM   719  O  O   . TYR A 1 98  ? 37.66352  -5.17875  -8.96866  1.000 40.05591  ?  98   TYR A O   1 
ATOM   720  C  CB  . TYR A 1 98  ? 39.87419  -4.96653  -6.39261  1.000 37.79834  ?  98   TYR A CB  1 
ATOM   721  C  CG  . TYR A 1 98  ? 40.35445  -6.25938  -7.01828  1.000 42.72333  ?  98   TYR A CG  1 
ATOM   722  C  CD1 . TYR A 1 98  ? 41.56173  -6.31873  -7.71765  1.000 47.36063  ?  98   TYR A CD1 1 
ATOM   723  C  CD2 . TYR A 1 98  ? 39.60166  -7.43187  -6.90884  1.000 49.40469  ?  98   TYR A CD2 1 
ATOM   724  C  CE1 . TYR A 1 98  ? 42.00059  -7.51313  -8.31269  1.000 45.12995  ?  98   TYR A CE1 1 
ATOM   725  C  CE2 . TYR A 1 98  ? 40.03193  -8.62537  -7.48629  1.000 51.16737  ?  98   TYR A CE2 1 
ATOM   726  C  CZ  . TYR A 1 98  ? 41.22900  -8.65970  -8.18609  1.000 54.87662  ?  98   TYR A CZ  1 
ATOM   727  O  OH  . TYR A 1 98  ? 41.62786  -9.85857  -8.74824  1.000 57.26172  ?  98   TYR A OH  1 
ATOM   728  N  N   . ALA A 1 99  ? 36.74111  -4.79796  -6.94904  1.000 30.98202  ?  99   ALA A N   1 
ATOM   729  C  CA  . ALA A 1 99  ? 35.44906  -5.34068  -7.35142  1.000 34.93669  ?  99   ALA A CA  1 
ATOM   730  C  C   . ALA A 1 99  ? 34.87798  -4.59404  -8.55668  1.000 37.08119  ?  99   ALA A C   1 
ATOM   731  O  O   . ALA A 1 99  ? 34.39173  -5.20880  -9.51585  1.000 36.20318  ?  99   ALA A O   1 
ATOM   732  C  CB  . ALA A 1 99  ? 34.46716  -5.27106  -6.17317  1.000 33.91997  ?  99   ALA A CB  1 
ATOM   733  N  N   . VAL A 1 100 ? 34.89306  -3.26362  -8.50987  1.000 29.31615  ?  100  VAL A N   1 
ATOM   734  C  CA  . VAL A 1 100 ? 34.35037  -2.49434  -9.62789  1.000 34.88469  ?  100  VAL A CA  1 
ATOM   735  C  C   . VAL A 1 100 ? 35.08940  -2.83402  -10.92743 1.000 39.71863  ?  100  VAL A C   1 
ATOM   736  O  O   . VAL A 1 100 ? 34.47692  -2.96228  -11.99803 1.000 37.63334  ?  100  VAL A O   1 
ATOM   737  C  CB  . VAL A 1 100 ? 34.41704  -0.98221  -9.32291  1.000 34.21035  ?  100  VAL A CB  1 
ATOM   738  C  CG1 . VAL A 1 100 ? 34.33278  -0.18169  -10.62390 1.000 32.72366  ?  100  VAL A CG1 1 
ATOM   739  C  CG2 . VAL A 1 100 ? 33.30303  -0.59835  -8.37713  1.000 28.85916  ?  100  VAL A CG2 1 
ATOM   740  N  N   . GLU A 1 101 ? 36.41601  -2.98441  -10.85326 1.000 36.84892  ?  101  GLU A N   1 
ATOM   741  C  CA  . GLU A 1 101 ? 37.21058  -3.18131  -12.06296 1.000 38.29032  ?  101  GLU A CA  1 
ATOM   742  C  C   . GLU A 1 101 ? 37.05590  -4.58215  -12.64621 1.000 42.27830  ?  101  GLU A C   1 
ATOM   743  O  O   . GLU A 1 101 ? 37.01686  -4.74208  -13.87179 1.000 45.02392  ?  101  GLU A O   1 
ATOM   744  C  CB  . GLU A 1 101 ? 38.67257  -2.86348  -11.77187 1.000 40.90804  ?  101  GLU A CB  1 
ATOM   745  C  CG  . GLU A 1 101 ? 38.90132  -1.36493  -11.74673 1.000 37.96441  ?  101  GLU A CG  1 
ATOM   746  C  CD  . GLU A 1 101 ? 40.34026  -0.95646  -11.52005 1.000 45.48827  ?  101  GLU A CD  1 
ATOM   747  O  OE1 . GLU A 1 101 ? 41.25929  -1.79968  -11.66955 1.000 51.71361  ?  101  GLU A OE1 1 
ATOM   748  O  OE2 . GLU A 1 101 ? 40.54310  0.23793   -11.20669 1.000 51.16559  -1 101  GLU A OE2 1 
ATOM   749  N  N   . ARG A 1 102 ? 36.94769  -5.59750  -11.80460 1.000 39.66900  ?  102  ARG A N   1 
ATOM   750  C  CA  . ARG A 1 102 ? 36.95913  -6.97218  -12.28664 1.000 39.26631  ?  102  ARG A CA  1 
ATOM   751  C  C   . ARG A 1 102 ? 35.57132  -7.56240  -12.50480 1.000 39.57782  ?  102  ARG A C   1 
ATOM   752  O  O   . ARG A 1 102 ? 35.45994  -8.69828  -12.97858 1.000 49.25692  ?  102  ARG A O   1 
ATOM   753  C  CB  . ARG A 1 102 ? 37.74100  -7.85851  -11.30803 1.000 47.05442  ?  102  ARG A CB  1 
ATOM   754  C  CG  . ARG A 1 102 ? 39.24864  -7.81778  -11.52209 1.000 52.95657  ?  102  ARG A CG  1 
ATOM   755  C  CD  . ARG A 1 102 ? 39.59826  -7.99338  -13.01579 1.000 61.22352  ?  102  ARG A CD  1 
ATOM   756  N  NE  . ARG A 1 102 ? 40.88793  -7.39853  -13.36826 1.000 75.72353  ?  102  ARG A NE  1 
ATOM   757  C  CZ  . ARG A 1 102 ? 41.61028  -7.72773  -14.43464 1.000 76.90993  ?  102  ARG A CZ  1 
ATOM   758  N  NH1 . ARG A 1 102 ? 41.22302  -8.68290  -15.26716 1.000 74.21385  ?  102  ARG A NH1 1 
ATOM   759  N  NH2 . ARG A 1 102 ? 42.75795  -7.09181  -14.66381 1.000 70.07008  ?  102  ARG A NH2 1 
ATOM   760  N  N   . LEU A 1 103 ? 34.51110  -6.84949  -12.16526 1.000 41.19933  ?  103  LEU A N   1 
ATOM   761  C  CA  . LEU A 1 103 ? 33.16052  -7.35717  -12.33631 1.000 41.59768  ?  103  LEU A CA  1 
ATOM   762  C  C   . LEU A 1 103 ? 32.37153  -6.37539  -13.18168 1.000 42.63917  ?  103  LEU A C   1 
ATOM   763  O  O   . LEU A 1 103 ? 32.82493  -5.25760  -13.44406 1.000 43.31660  ?  103  LEU A O   1 
ATOM   764  C  CB  . LEU A 1 103 ? 32.47220  -7.57422  -10.98065 1.000 34.61874  ?  103  LEU A CB  1 
ATOM   765  C  CG  . LEU A 1 103 ? 33.20450  -8.55046  -10.05475 1.000 41.39212  ?  103  LEU A CG  1 
ATOM   766  C  CD1 . LEU A 1 103 ? 32.68543  -8.38499  -8.64602  1.000 40.22910  ?  103  LEU A CD1 1 
ATOM   767  C  CD2 . LEU A 1 103 ? 33.05132  -9.99975  -10.51796 1.000 42.37045  ?  103  LEU A CD2 1 
ATOM   768  N  N   . ASN A 1 104 ? 31.16259  -6.78878  -13.56654 1.000 40.30329  ?  104  ASN A N   1 
ATOM   769  C  CA  . ASN A 1 104 ? 30.28691  -5.91156  -14.33186 1.000 43.65921  ?  104  ASN A CA  1 
ATOM   770  C  C   . ASN A 1 104 ? 29.84912  -4.71511  -13.47392 1.000 38.15253  ?  104  ASN A C   1 
ATOM   771  O  O   . ASN A 1 104 ? 30.04669  -4.70498  -12.25509 1.000 40.10786  ?  104  ASN A O   1 
ATOM   772  C  CB  . ASN A 1 104 ? 29.09355  -6.70947  -14.88880 1.000 41.48540  ?  104  ASN A CB  1 
ATOM   773  C  CG  . ASN A 1 104 ? 28.10014  -7.15810  -13.81677 1.000 45.89570  ?  104  ASN A CG  1 
ATOM   774  O  OD1 . ASN A 1 104 ? 27.66076  -6.37009  -12.97558 1.000 42.10282  ?  104  ASN A OD1 1 
ATOM   775  N  ND2 . ASN A 1 104 ? 27.71035  -8.43669  -13.87609 1.000 39.07839  ?  104  ASN A ND2 1 
ATOM   776  N  N   . PRO A 1 105 ? 29.31372  -3.66025  -14.10006 1.000 41.77921  ?  105  PRO A N   1 
ATOM   777  C  CA  . PRO A 1 105 ? 29.04310  -2.42049  -13.33671 1.000 40.10420  ?  105  PRO A CA  1 
ATOM   778  C  C   . PRO A 1 105 ? 28.13941  -2.60219  -12.13384 1.000 41.24166  ?  105  PRO A C   1 
ATOM   779  O  O   . PRO A 1 105 ? 28.42820  -2.03944  -11.06362 1.000 34.57786  ?  105  PRO A O   1 
ATOM   780  C  CB  . PRO A 1 105 ? 28.39376  -1.51421  -14.38143 1.000 34.88426  ?  105  PRO A CB  1 
ATOM   781  C  CG  . PRO A 1 105 ? 29.02177  -1.94976  -15.65461 1.000 42.16420  ?  105  PRO A CG  1 
ATOM   782  C  CD  . PRO A 1 105 ? 29.18007  -3.44405  -15.55126 1.000 39.50109  ?  105  PRO A CD  1 
ATOM   783  N  N   . PHE A 1 106 ? 27.06687  -3.39444  -12.27552 1.000 36.87851  ?  106  PHE A N   1 
ATOM   784  C  CA  . PHE A 1 106 ? 26.07461  -3.50074  -11.21323 1.000 37.05603  ?  106  PHE A CA  1 
ATOM   785  C  C   . PHE A 1 106 ? 26.62999  -4.29069  -10.03209 1.000 37.06462  ?  106  PHE A C   1 
ATOM   786  O  O   . PHE A 1 106 ? 26.65979  -3.79069  -8.89968  1.000 35.18856  ?  106  PHE A O   1 
ATOM   787  C  CB  . PHE A 1 106 ? 24.79198  -4.13124  -11.76222 1.000 38.65575  ?  106  PHE A CB  1 
ATOM   788  C  CG  . PHE A 1 106 ? 23.73333  -4.36332  -10.72685 1.000 40.18441  ?  106  PHE A CG  1 
ATOM   789  C  CD1 . PHE A 1 106 ? 23.15059  -3.30795  -10.06774 1.000 37.80313  ?  106  PHE A CD1 1 
ATOM   790  C  CD2 . PHE A 1 106 ? 23.29669  -5.65476  -10.43877 1.000 39.02214  ?  106  PHE A CD2 1 
ATOM   791  C  CE1 . PHE A 1 106 ? 22.17517  -3.53066  -9.12278  1.000 41.18024  ?  106  PHE A CE1 1 
ATOM   792  C  CE2 . PHE A 1 106 ? 22.32111  -5.88087  -9.51034  1.000 38.52862  ?  106  PHE A CE2 1 
ATOM   793  C  CZ  . PHE A 1 106 ? 21.75019  -4.82381  -8.84740  1.000 40.92012  ?  106  PHE A CZ  1 
ATOM   794  N  N   . PHE A 1 107 ? 27.10686  -5.52185  -10.28289 1.000 33.22948  ?  107  PHE A N   1 
ATOM   795  C  CA  . PHE A 1 107 ? 27.65372  -6.33137  -9.19169  1.000 36.49974  ?  107  PHE A CA  1 
ATOM   796  C  C   . PHE A 1 107 ? 28.85707  -5.64776  -8.55154  1.000 33.27353  ?  107  PHE A C   1 
ATOM   797  O  O   . PHE A 1 107 ? 29.02049  -5.66874  -7.32053  1.000 34.42305  ?  107  PHE A O   1 
ATOM   798  C  CB  . PHE A 1 107 ? 28.05244  -7.71403  -9.70776  1.000 33.07187  ?  107  PHE A CB  1 
ATOM   799  C  CG  . PHE A 1 107 ? 26.89325  -8.56691  -10.14505 1.000 34.11423  ?  107  PHE A CG  1 
ATOM   800  C  CD1 . PHE A 1 107 ? 25.58051  -8.14613  -9.96341  1.000 34.82169  ?  107  PHE A CD1 1 
ATOM   801  C  CD2 . PHE A 1 107 ? 27.11894  -9.79356  -10.75939 1.000 38.85754  ?  107  PHE A CD2 1 
ATOM   802  C  CE1 . PHE A 1 107 ? 24.51544  -8.94360  -10.36763 1.000 39.02887  ?  107  PHE A CE1 1 
ATOM   803  C  CE2 . PHE A 1 107 ? 26.06027  -10.60534 -11.15488 1.000 37.03300  ?  107  PHE A CE2 1 
ATOM   804  C  CZ  . PHE A 1 107 ? 24.76023  -10.18281 -10.96946 1.000 39.15324  ?  107  PHE A CZ  1 
ATOM   805  N  N   . GLY A 1 108 ? 29.71939  -5.04429  -9.37918  1.000 32.77094  ?  108  GLY A N   1 
ATOM   806  C  CA  . GLY A 1 108 ? 30.93022  -4.43827  -8.86124  1.000 27.74858  ?  108  GLY A CA  1 
ATOM   807  C  C   . GLY A 1 108 ? 30.64036  -3.27633  -7.93789  1.000 28.97678  ?  108  GLY A C   1 
ATOM   808  O  O   . GLY A 1 108 ? 31.21698  -3.18049  -6.84769  1.000 28.49456  ?  108  GLY A O   1 
ATOM   809  N  N   . HIS A 1 109 ? 29.70877  -2.39300  -8.33880  1.000 30.71508  ?  109  HIS A N   1 
ATOM   810  C  CA  . HIS A 1 109 ? 29.39051  -1.26035  -7.47131  1.000 31.18172  ?  109  HIS A CA  1 
ATOM   811  C  C   . HIS A 1 109 ? 28.59884  -1.70913  -6.23720  1.000 29.95726  ?  109  HIS A C   1 
ATOM   812  O  O   . HIS A 1 109 ? 28.78484  -1.16327  -5.13307  1.000 30.27274  ?  109  HIS A O   1 
ATOM   813  C  CB  . HIS A 1 109 ? 28.65934  -0.19848  -8.29733  1.000 31.80456  ?  109  HIS A CB  1 
ATOM   814  C  CG  . HIS A 1 109 ? 29.55889  0.51543   -9.26286  1.000 33.44787  ?  109  HIS A CG  1 
ATOM   815  N  ND1 . HIS A 1 109 ? 29.83490  0.02436   -10.52452 1.000 31.03372  ?  109  HIS A ND1 1 
ATOM   816  C  CD2 . HIS A 1 109 ? 30.30612  1.64168   -9.12384  1.000 29.76725  ?  109  HIS A CD2 1 
ATOM   817  C  CE1 . HIS A 1 109 ? 30.68271  0.83357   -11.13341 1.000 32.55759  ?  109  HIS A CE1 1 
ATOM   818  N  NE2 . HIS A 1 109 ? 30.97651  1.82798   -10.31004 1.000 36.51536  ?  109  HIS A NE2 1 
ATOM   819  N  N   . LEU A 1 110 ? 27.76317  -2.74424  -6.38753  1.000 29.29992  ?  110  LEU A N   1 
ATOM   820  C  CA  . LEU A 1 110 ? 27.07006  -3.29242  -5.23288  1.000 32.62785  ?  110  LEU A CA  1 
ATOM   821  C  C   . LEU A 1 110 ? 28.07058  -3.72104  -4.16851  1.000 31.00787  ?  110  LEU A C   1 
ATOM   822  O  O   . LEU A 1 110 ? 27.97809  -3.30021  -3.00611  1.000 30.13538  ?  110  LEU A O   1 
ATOM   823  C  CB  . LEU A 1 110 ? 26.17843  -4.45811  -5.66150  1.000 29.76718  ?  110  LEU A CB  1 
ATOM   824  C  CG  . LEU A 1 110 ? 25.15911  -4.97106  -4.61637  1.000 38.06860  ?  110  LEU A CG  1 
ATOM   825  C  CD1 . LEU A 1 110 ? 23.92042  -5.55560  -5.26373  1.000 33.87051  ?  110  LEU A CD1 1 
ATOM   826  C  CD2 . LEU A 1 110 ? 25.75408  -6.01674  -3.65504  1.000 29.74219  ?  110  LEU A CD2 1 
ATOM   827  N  N   . LEU A 1 111 ? 29.06399  -4.52278  -4.56315  1.000 28.18987  ?  111  LEU A N   1 
ATOM   828  C  CA  . LEU A 1 111 ? 30.06719  -4.96478  -3.60118  1.000 25.90258  ?  111  LEU A CA  1 
ATOM   829  C  C   . LEU A 1 111 ? 30.87040  -3.78827  -3.06094  1.000 30.05704  ?  111  LEU A C   1 
ATOM   830  O  O   . LEU A 1 111 ? 31.20804  -3.74944  -1.86281  1.000 28.42669  ?  111  LEU A O   1 
ATOM   831  C  CB  . LEU A 1 111 ? 30.99368  -5.99721  -4.23059  1.000 32.98770  ?  111  LEU A CB  1 
ATOM   832  C  CG  . LEU A 1 111 ? 30.30776  -7.31762  -4.55127  1.000 28.33486  ?  111  LEU A CG  1 
ATOM   833  C  CD1 . LEU A 1 111 ? 31.17464  -8.03719  -5.50784  1.000 32.53318  ?  111  LEU A CD1 1 
ATOM   834  C  CD2 . LEU A 1 111 ? 30.11328  -8.13141  -3.28351  1.000 35.29080  ?  111  LEU A CD2 1 
ATOM   835  N  N   . ALA A 1 112 ? 31.18012  -2.81913  -3.92114  1.000 30.30620  ?  112  ALA A N   1 
ATOM   836  C  CA  . ALA A 1 112 ? 31.94641  -1.67567  -3.44300  1.000 29.95820  ?  112  ALA A CA  1 
ATOM   837  C  C   . ALA A 1 112 ? 31.25555  -1.00706  -2.26031  1.000 30.33772  ?  112  ALA A C   1 
ATOM   838  O  O   . ALA A 1 112 ? 31.93048  -0.58085  -1.31305  1.000 33.37038  ?  112  ALA A O   1 
ATOM   839  C  CB  . ALA A 1 112 ? 32.18843  -0.69720  -4.58610  1.000 29.09289  ?  112  ALA A CB  1 
ATOM   840  N  N   . TYR A 1 113 ? 29.90603  -0.92716  -2.27434  1.000 28.05602  ?  113  TYR A N   1 
ATOM   841  C  CA  . TYR A 1 113 ? 29.22705  -0.29476  -1.13201  1.000 28.82298  ?  113  TYR A CA  1 
ATOM   842  C  C   . TYR A 1 113 ? 29.58389  -0.99764  0.18267   1.000 32.43014  ?  113  TYR A C   1 
ATOM   843  O  O   . TYR A 1 113 ? 29.93391  -0.34799  1.17932   1.000 30.03076  ?  113  TYR A O   1 
ATOM   844  C  CB  . TYR A 1 113 ? 27.71006  -0.29942  -1.31237  1.000 28.93511  ?  113  TYR A CB  1 
ATOM   845  C  CG  . TYR A 1 113 ? 27.08012  0.86381   -2.08479  1.000 27.57832  ?  113  TYR A CG  1 
ATOM   846  C  CD1 . TYR A 1 113 ? 26.63131  2.00541   -1.42350  1.000 27.88916  ?  113  TYR A CD1 1 
ATOM   847  C  CD2 . TYR A 1 113 ? 26.89120  0.79324   -3.46100  1.000 26.50288  ?  113  TYR A CD2 1 
ATOM   848  C  CE1 . TYR A 1 113 ? 26.01447  3.04535   -2.11497  1.000 27.42333  ?  113  TYR A CE1 1 
ATOM   849  C  CE2 . TYR A 1 113 ? 26.27871  1.85010   -4.16896  1.000 27.61403  ?  113  TYR A CE2 1 
ATOM   850  C  CZ  . TYR A 1 113 ? 25.84143  2.95980   -3.47409  1.000 27.02969  ?  113  TYR A CZ  1 
ATOM   851  O  OH  . TYR A 1 113 ? 25.23702  4.01246   -4.13780  1.000 36.57659  ?  113  TYR A OH  1 
ATOM   852  N  N   . LEU A 1 114 ? 29.51405  -2.33740  0.19227   1.000 27.70943  ?  114  LEU A N   1 
ATOM   853  C  CA  . LEU A 1 114 ? 29.74953  -3.10952  1.40810   1.000 34.27337  ?  114  LEU A CA  1 
ATOM   854  C  C   . LEU A 1 114 ? 31.20207  -3.00761  1.83732   1.000 31.71696  ?  114  LEU A C   1 
ATOM   855  O  O   . LEU A 1 114 ? 31.49963  -2.79134  3.02263   1.000 30.81332  ?  114  LEU A O   1 
ATOM   856  C  CB  . LEU A 1 114 ? 29.36239  -4.59724  1.20417   1.000 30.01588  ?  114  LEU A CB  1 
ATOM   857  C  CG  . LEU A 1 114 ? 28.16359  -5.02990  0.33527   1.000 29.84347  ?  114  LEU A CG  1 
ATOM   858  C  CD1 . LEU A 1 114 ? 28.07536  -6.58773  0.05561   1.000 26.71139  ?  114  LEU A CD1 1 
ATOM   859  C  CD2 . LEU A 1 114 ? 26.86587  -4.57852  0.95953   1.000 28.13449  ?  114  LEU A CD2 1 
ATOM   860  N  N   . ILE A 1 115 ? 32.12080  -3.16042  0.88160   1.000 35.28951  ?  115  ILE A N   1 
ATOM   861  C  CA  . ILE A 1 115 ? 33.54143  -3.21997  1.22092   1.000 34.85195  ?  115  ILE A CA  1 
ATOM   862  C  C   . ILE A 1 115 ? 34.01765  -1.87193  1.71514   1.000 29.75801  ?  115  ILE A C   1 
ATOM   863  O  O   . ILE A 1 115 ? 34.74965  -1.77867  2.70824   1.000 33.11198  ?  115  ILE A O   1 
ATOM   864  C  CB  . ILE A 1 115 ? 34.38497  -3.67785  0.02296   1.000 32.63479  ?  115  ILE A CB  1 
ATOM   865  C  CG1 . ILE A 1 115 ? 34.11206  -5.12517  -0.33058  1.000 29.57837  ?  115  ILE A CG1 1 
ATOM   866  C  CG2 . ILE A 1 115 ? 35.87639  -3.49723  0.32607   1.000 34.60811  ?  115  ILE A CG2 1 
ATOM   867  C  CD1 . ILE A 1 115 ? 34.58530  -5.41735  -1.72546  1.000 32.49995  ?  115  ILE A CD1 1 
ATOM   868  N  N   . ALA A 1 116 ? 33.62729  -0.80972  1.02693   1.000 32.02069  ?  116  ALA A N   1 
ATOM   869  C  CA  . ALA A 1 116 ? 34.12279  0.50753   1.40863   1.000 29.93505  ?  116  ALA A CA  1 
ATOM   870  C  C   . ALA A 1 116 ? 33.44007  1.03248   2.65809   1.000 30.26157  ?  116  ALA A C   1 
ATOM   871  O  O   . ALA A 1 116 ? 33.95274  1.96534   3.28604   1.000 33.04768  ?  116  ALA A O   1 
ATOM   872  C  CB  . ALA A 1 116 ? 33.93175  1.50326   0.26929   1.000 30.59101  ?  116  ALA A CB  1 
ATOM   873  N  N   . GLY A 1 117 ? 32.29000  0.48147   3.02178   1.000 28.46572  ?  117  GLY A N   1 
ATOM   874  C  CA  . GLY A 1 117 ? 31.62671  0.90794   4.23062   1.000 24.06450  ?  117  GLY A CA  1 
ATOM   875  C  C   . GLY A 1 117 ? 31.96018  0.11412   5.47371   1.000 28.14970  ?  117  GLY A C   1 
ATOM   876  O  O   . GLY A 1 117 ? 31.39619  0.40803   6.54199   1.000 23.18038  ?  117  GLY A O   1 
ATOM   877  N  N   . HIS A 1 118 ? 32.87012  -0.87243  5.38139   1.000 28.12284  ?  118  HIS A N   1 
ATOM   878  C  CA  . HIS A 1 118 ? 33.02340  -1.80506  6.49420   1.000 27.20216  ?  118  HIS A CA  1 
ATOM   879  C  C   . HIS A 1 118 ? 33.68227  -1.16818  7.71813   1.000 31.60161  ?  118  HIS A C   1 
ATOM   880  O  O   . HIS A 1 118 ? 33.61805  -1.75134  8.80634   1.000 35.21012  ?  118  HIS A O   1 
ATOM   881  C  CB  . HIS A 1 118 ? 33.74688  -3.08106  6.01663   1.000 26.85710  ?  118  HIS A CB  1 
ATOM   882  C  CG  . HIS A 1 118 ? 35.25241  -3.05011  6.11046   1.000 32.36850  ?  118  HIS A CG  1 
ATOM   883  N  ND1 . HIS A 1 118 ? 36.05827  -2.86438  5.00668   1.000 28.45348  ?  118  HIS A ND1 1 
ATOM   884  C  CD2 . HIS A 1 118 ? 36.09415  -3.27793  7.14766   1.000 29.39754  ?  118  HIS A CD2 1 
ATOM   885  C  CE1 . HIS A 1 118 ? 37.33031  -2.93521  5.36289   1.000 29.22491  ?  118  HIS A CE1 1 
ATOM   886  N  NE2 . HIS A 1 118 ? 37.38271  -3.17922  6.65925   1.000 30.50600  ?  118  HIS A NE2 1 
ATOM   887  N  N   . HIS A 1 119 ? 34.23111  0.03735   7.60789   1.000 29.76031  ?  119  HIS A N   1 
ATOM   888  C  CA  . HIS A 1 119 ? 34.51328  0.85018   8.79126   1.000 27.12795  ?  119  HIS A CA  1 
ATOM   889  C  C   . HIS A 1 119 ? 33.57754  2.04583   8.94245   1.000 31.20716  ?  119  HIS A C   1 
ATOM   890  O  O   . HIS A 1 119 ? 32.98407  2.23507   10.00414  1.000 28.59148  ?  119  HIS A O   1 
ATOM   891  C  CB  . HIS A 1 119 ? 35.97685  1.33484   8.77241   1.000 30.22989  ?  119  HIS A CB  1 
ATOM   892  C  CG  . HIS A 1 119 ? 36.97689  0.23933   8.95177   1.000 30.23362  ?  119  HIS A CG  1 
ATOM   893  N  ND1 . HIS A 1 119 ? 37.39265  -0.18302  10.19353  1.000 34.85319  ?  119  HIS A ND1 1 
ATOM   894  C  CD2 . HIS A 1 119 ? 37.63754  -0.52893  8.05010   1.000 28.35353  ?  119  HIS A CD2 1 
ATOM   895  C  CE1 . HIS A 1 119 ? 38.27350  -1.15544  10.04983  1.000 32.98354  ?  119  HIS A CE1 1 
ATOM   896  N  NE2 . HIS A 1 119 ? 38.43563  -1.38474  8.76136   1.000 28.84829  ?  119  HIS A NE2 1 
ATOM   897  N  N   . ALA A 1 120 ? 33.42503  2.87977   7.90523   1.000 33.40667  ?  120  ALA A N   1 
ATOM   898  C  CA  . ALA A 1 120 ? 32.73608  4.15708   8.06821   1.000 29.88196  ?  120  ALA A CA  1 
ATOM   899  C  C   . ALA A 1 120 ? 31.22314  4.03590   8.06410   1.000 31.25202  ?  120  ALA A C   1 
ATOM   900  O  O   . ALA A 1 120 ? 30.54135  5.02856   8.34135   1.000 31.31566  ?  120  ALA A O   1 
ATOM   901  C  CB  . ALA A 1 120 ? 33.14017  5.13413   6.95322   1.000 35.77514  ?  120  ALA A CB  1 
ATOM   902  N  N   . GLY A 1 121 ? 30.68746  2.88301   7.71735   1.000 27.13529  ?  121  GLY A N   1 
ATOM   903  C  CA  . GLY A 1 121 ? 29.26777  2.74651   7.47599   1.000 25.42082  ?  121  GLY A CA  1 
ATOM   904  C  C   . GLY A 1 121 ? 28.95600  2.88580   5.99512   1.000 27.35287  ?  121  GLY A C   1 
ATOM   905  O  O   . GLY A 1 121 ? 29.72232  3.46156   5.22786   1.000 26.98600  ?  121  GLY A O   1 
ATOM   906  N  N   . LEU A 1 122 ? 27.83736  2.29516   5.57784   1.000 29.22377  ?  122  LEU A N   1 
ATOM   907  C  CA  . LEU A 1 122 ? 27.36711  2.43099   4.20779   1.000 30.52382  ?  122  LEU A CA  1 
ATOM   908  C  C   . LEU A 1 122 ? 27.15917  3.90620   3.87877   1.000 28.33284  ?  122  LEU A C   1 
ATOM   909  O  O   . LEU A 1 122 ? 26.55401  4.63678   4.66445   1.000 28.65038  ?  122  LEU A O   1 
ATOM   910  C  CB  . LEU A 1 122 ? 26.05472  1.65325   4.03101   1.000 22.80087  ?  122  LEU A CB  1 
ATOM   911  C  CG  . LEU A 1 122 ? 26.14045  0.12084   4.15137   1.000 31.58472  ?  122  LEU A CG  1 
ATOM   912  C  CD1 . LEU A 1 122 ? 24.76439  -0.54167  4.47930   1.000 22.03526  ?  122  LEU A CD1 1 
ATOM   913  C  CD2 . LEU A 1 122 ? 26.73214  -0.41338  2.85623   1.000 23.76306  ?  122  LEU A CD2 1 
ATOM   914  N  N   . ALA A 1 123 ? 27.61895  4.33596   2.69207   1.000 30.08550  ?  123  ALA A N   1 
ATOM   915  C  CA  . ALA A 1 123 ? 27.55231  5.74810   2.30537   1.000 34.28341  ?  123  ALA A CA  1 
ATOM   916  C  C   . ALA A 1 123 ? 26.45651  6.03306   1.27941   1.000 30.74139  ?  123  ALA A C   1 
ATOM   917  O  O   . ALA A 1 123 ? 25.80816  5.13026   0.74064   1.000 25.12879  ?  123  ALA A O   1 
ATOM   918  C  CB  . ALA A 1 123 ? 28.90343  6.23024   1.75933   1.000 35.21317  ?  123  ALA A CB  1 
ATOM   919  N  N   . ASP A 1 124 ? 26.22323  7.33224   1.03984   1.000 28.48349  ?  124  ASP A N   1 
ATOM   920  C  CA  . ASP A 1 124 ? 25.51643  7.74151   -0.17316  1.000 27.12982  ?  124  ASP A CA  1 
ATOM   921  C  C   . ASP A 1 124 ? 26.44434  7.56941   -1.36221  1.000 28.87102  ?  124  ASP A C   1 
ATOM   922  O  O   . ASP A 1 124 ? 27.66856  7.46803   -1.21036  1.000 31.36547  ?  124  ASP A O   1 
ATOM   923  C  CB  . ASP A 1 124 ? 25.05830  9.20693   -0.13199  1.000 31.52629  ?  124  ASP A CB  1 
ATOM   924  C  CG  . ASP A 1 124 ? 24.22543  9.54388   1.07872   1.000 34.13458  ?  124  ASP A CG  1 
ATOM   925  O  OD1 . ASP A 1 124 ? 23.59094  8.63484   1.66907   1.000 33.84483  ?  124  ASP A OD1 1 
ATOM   926  O  OD2 . ASP A 1 124 ? 24.18404  10.75100  1.42537   1.000 37.13711  -1 124  ASP A OD2 1 
ATOM   927  N  N   . TRP A 1 125 ? 25.85594  7.53339   -2.56085  1.000 29.54476  ?  125  TRP A N   1 
ATOM   928  C  CA  . TRP A 1 125 ? 26.67515  7.52637   -3.77163  1.000 29.19702  ?  125  TRP A CA  1 
ATOM   929  C  C   . TRP A 1 125 ? 27.24104  8.91921   -4.04579  1.000 30.14687  ?  125  TRP A C   1 
ATOM   930  O  O   . TRP A 1 125 ? 28.46126  9.11449   -4.11071  1.000 31.59216  ?  125  TRP A O   1 
ATOM   931  C  CB  . TRP A 1 125 ? 25.84731  7.03283   -4.95643  1.000 28.19348  ?  125  TRP A CB  1 
ATOM   932  C  CG  . TRP A 1 125 ? 26.57440  7.02307   -6.25671  1.000 28.88668  ?  125  TRP A CG  1 
ATOM   933  C  CD1 . TRP A 1 125 ? 26.32448  7.82968   -7.32643  1.000 34.75674  ?  125  TRP A CD1 1 
ATOM   934  C  CD2 . TRP A 1 125 ? 27.67516  6.18414   -6.63484  1.000 29.27609  ?  125  TRP A CD2 1 
ATOM   935  N  NE1 . TRP A 1 125 ? 27.18595  7.53898   -8.34524  1.000 33.81114  ?  125  TRP A NE1 1 
ATOM   936  C  CE2 . TRP A 1 125 ? 28.02761  6.53419   -7.95327  1.000 34.13810  ?  125  TRP A CE2 1 
ATOM   937  C  CE3 . TRP A 1 125 ? 28.37764  5.15473   -5.99943  1.000 29.95420  ?  125  TRP A CE3 1 
ATOM   938  C  CZ2 . TRP A 1 125 ? 29.06764  5.90019   -8.65354  1.000 35.43232  ?  125  TRP A CZ2 1 
ATOM   939  C  CZ3 . TRP A 1 125 ? 29.42840  4.52608   -6.68654  1.000 28.57994  ?  125  TRP A CZ3 1 
ATOM   940  C  CH2 . TRP A 1 125 ? 29.75947  4.90087   -8.00094  1.000 34.82346  ?  125  TRP A CH2 1 
ATOM   941  N  N   . TYR A 1 126 ? 26.35984  9.89732   -4.20607  1.000 31.65094  ?  126  TYR A N   1 
ATOM   942  C  CA  . TYR A 1 126 ? 26.78201  11.25505  -4.51860  1.000 31.96892  ?  126  TYR A CA  1 
ATOM   943  C  C   . TYR A 1 126 ? 27.13991  12.04805  -3.27526  1.000 34.95501  ?  126  TYR A C   1 
ATOM   944  O  O   . TYR A 1 126 ? 28.08314  12.85121  -3.31729  1.000 35.29520  ?  126  TYR A O   1 
ATOM   945  C  CB  . TYR A 1 126 ? 25.68313  12.00964  -5.28046  1.000 30.96296  ?  126  TYR A CB  1 
ATOM   946  C  CG  . TYR A 1 126 ? 25.24774  11.40256  -6.60130  1.000 33.92442  ?  126  TYR A CG  1 
ATOM   947  C  CD1 . TYR A 1 126 ? 26.04342  11.50274  -7.74974  1.000 31.43302  ?  126  TYR A CD1 1 
ATOM   948  C  CD2 . TYR A 1 126 ? 24.01668  10.75736  -6.70924  1.000 29.39152  ?  126  TYR A CD2 1 
ATOM   949  C  CE1 . TYR A 1 126 ? 25.62463  10.95655  -8.97054  1.000 30.75617  ?  126  TYR A CE1 1 
ATOM   950  C  CE2 . TYR A 1 126 ? 23.58936  10.21902  -7.91167  1.000 28.17889  ?  126  TYR A CE2 1 
ATOM   951  C  CZ  . TYR A 1 126 ? 24.38804  10.30885  -9.03702  1.000 32.32567  ?  126  TYR A CZ  1 
ATOM   952  O  OH  . TYR A 1 126 ? 23.91412  9.73807   -10.21300 1.000 36.37618  ?  126  TYR A OH  1 
ATOM   953  N  N   . ASP A 1 127 ? 26.36714  11.89538  -2.18624  1.000 37.44644  ?  127  ASP A N   1 
ATOM   954  C  CA  . ASP A 1 127 ? 26.47187  12.89228  -1.12420  1.000 37.77728  ?  127  ASP A CA  1 
ATOM   955  C  C   . ASP A 1 127 ? 27.31056  12.53019  0.10725   1.000 37.78353  ?  127  ASP A C   1 
ATOM   956  O  O   . ASP A 1 127 ? 28.53792  12.68160  0.07711   1.000 37.66132  ?  127  ASP A O   1 
ATOM   957  C  CB  . ASP A 1 127 ? 25.04752  13.21402  -0.65702  1.000 33.53595  ?  127  ASP A CB  1 
ATOM   958  C  CG  . ASP A 1 127 ? 24.96349  14.51173  0.13624   1.000 43.76709  ?  127  ASP A CG  1 
ATOM   959  O  OD1 . ASP A 1 127 ? 26.00911  14.99430  0.62543   1.000 43.46124  ?  127  ASP A OD1 1 
ATOM   960  O  OD2 . ASP A 1 127 ? 23.83404  15.01112  0.33997   1.000 54.47955  -1 127  ASP A OD2 1 
ATOM   961  N  N   . LYS A 1 128 ? 26.70703  11.87505  1.10724   1.000 35.64734  ?  128  LYS A N   1 
ATOM   962  C  CA  . LYS A 1 128 ? 27.36073  11.76123  2.40686   1.000 35.63089  ?  128  LYS A CA  1 
ATOM   963  C  C   . LYS A 1 128 ? 28.32227  10.58569  2.38980   1.000 36.96651  ?  128  LYS A C   1 
ATOM   964  O  O   . LYS A 1 128 ? 27.91336  9.44968   2.13809   1.000 36.22652  ?  128  LYS A O   1 
ATOM   965  C  CB  . LYS A 1 128 ? 26.34024  11.59970  3.52555   1.000 37.49839  ?  128  LYS A CB  1 
ATOM   966  C  CG  . LYS A 1 128 ? 25.65356  12.88890  3.98567   1.000 43.20656  ?  128  LYS A CG  1 
ATOM   967  C  CD  . LYS A 1 128 ? 24.73855  12.63804  5.20139   1.000 40.77737  ?  128  LYS A CD  1 
ATOM   968  C  CE  . LYS A 1 128 ? 23.90317  13.87937  5.53325   1.000 46.28627  ?  128  LYS A CE  1 
ATOM   969  N  NZ  . LYS A 1 128 ? 23.08797  14.31961  4.35756   1.000 45.72786  ?  128  LYS A NZ  1 
ATOM   970  N  N   . GLY A 1 129 ? 29.59693  10.85308  2.65837   1.000 37.07852  ?  129  GLY A N   1 
ATOM   971  C  CA  . GLY A 1 129 ? 30.59942  9.81233   2.53270   1.000 38.48430  ?  129  GLY A CA  1 
ATOM   972  C  C   . GLY A 1 129 ? 30.77266  9.32390   1.11487   1.000 34.77243  ?  129  GLY A C   1 
ATOM   973  O  O   . GLY A 1 129 ? 31.25615  8.20745   0.90872   1.000 32.46014  ?  129  GLY A O   1 
ATOM   974  N  N   . SER A 1 130 ? 30.51072  10.19240  0.13544   1.000 37.43745  ?  130  SER A N   1 
ATOM   975  C  CA  . SER A 1 130 ? 30.23057  9.81800   -1.24386  1.000 32.15774  ?  130  SER A CA  1 
ATOM   976  C  C   . SER A 1 130 ? 31.11043  8.68980   -1.74233  1.000 30.73541  ?  130  SER A C   1 
ATOM   977  O  O   . SER A 1 130 ? 32.32405  8.85393   -1.91771  1.000 34.78406  ?  130  SER A O   1 
ATOM   978  C  CB  . SER A 1 130 ? 30.43915  11.02039  -2.16360  1.000 33.70629  ?  130  SER A CB  1 
ATOM   979  O  OG  . SER A 1 130 ? 30.56066  10.59456  -3.52013  1.000 32.24130  ?  130  SER A OG  1 
ATOM   980  N  N   . LEU A 1 131 ? 30.47773  7.55386   -2.02684  1.000 35.36321  ?  131  LEU A N   1 
ATOM   981  C  CA  . LEU A 1 131 ? 31.20949  6.40249   -2.53435  1.000 30.80190  ?  131  LEU A CA  1 
ATOM   982  C  C   . LEU A 1 131 ? 31.74142  6.67400   -3.93343  1.000 33.18725  ?  131  LEU A C   1 
ATOM   983  O  O   . LEU A 1 131 ? 32.76863  6.10340   -4.32314  1.000 28.43502  ?  131  LEU A O   1 
ATOM   984  C  CB  . LEU A 1 131 ? 30.29796  5.18417   -2.52358  1.000 27.98335  ?  131  LEU A CB  1 
ATOM   985  C  CG  . LEU A 1 131 ? 30.84657  3.89619   -3.11760  1.000 28.08331  ?  131  LEU A CG  1 
ATOM   986  C  CD1 . LEU A 1 131 ? 32.10762  3.48163   -2.36971  1.000 26.01237  ?  131  LEU A CD1 1 
ATOM   987  C  CD2 . LEU A 1 131 ? 29.73802  2.79980   -3.10603  1.000 30.35395  ?  131  LEU A CD2 1 
ATOM   988  N  N   . LYS A 1 132 ? 31.05888  7.54723   -4.69623  1.000 29.57543  ?  132  LYS A N   1 
ATOM   989  C  CA  . LYS A 1 132 ? 31.52240  7.85773   -6.04081  1.000 30.79400  ?  132  LYS A CA  1 
ATOM   990  C  C   . LYS A 1 132 ? 32.89655  8.52184   -5.98758  1.000 36.63295  ?  132  LYS A C   1 
ATOM   991  O  O   . LYS A 1 132 ? 33.83715  8.08753   -6.66592  1.000 34.91020  ?  132  LYS A O   1 
ATOM   992  C  CB  . LYS A 1 132 ? 30.49945  8.73510   -6.75799  1.000 33.75771  ?  132  LYS A CB  1 
ATOM   993  C  CG  . LYS A 1 132 ? 30.83702  9.04273   -8.23404  1.000 33.96613  ?  132  LYS A CG  1 
ATOM   994  C  CD  . LYS A 1 132 ? 29.85330  10.07522  -8.78895  1.000 37.26564  ?  132  LYS A CD  1 
ATOM   995  C  CE  . LYS A 1 132 ? 30.14927  10.45587  -10.25545 1.000 36.47196  ?  132  LYS A CE  1 
ATOM   996  N  NZ  . LYS A 1 132 ? 29.69019  9.43196   -11.22155 1.000 39.04863  ?  132  LYS A NZ  1 
ATOM   997  N  N   . ARG A 1 133 ? 33.04861  9.52980   -5.12216  1.000 37.43350  ?  133  ARG A N   1 
ATOM   998  C  CA  . ARG A 1 133 ? 34.34230  10.19365  -4.96138  1.000 39.22789  ?  133  ARG A CA  1 
ATOM   999  C  C   . ARG A 1 133 ? 35.41505  9.21354   -4.47840  1.000 40.97481  ?  133  ARG A C   1 
ATOM   1000 O  O   . ARG A 1 133 ? 36.53101  9.16926   -5.01783  1.000 39.18582  ?  133  ARG A O   1 
ATOM   1001 C  CB  . ARG A 1 133 ? 34.20702  11.36817  -3.98473  1.000 36.06080  ?  133  ARG A CB  1 
ATOM   1002 C  CG  . ARG A 1 133 ? 35.53651  11.92538  -3.46274  1.000 39.95365  ?  133  ARG A CG  1 
ATOM   1003 C  CD  . ARG A 1 133 ? 36.27952  12.80351  -4.51412  1.000 52.31286  ?  133  ARG A CD  1 
ATOM   1004 N  NE  . ARG A 1 133 ? 37.54660  13.35957  -4.01878  1.000 57.12277  ?  133  ARG A NE  1 
ATOM   1005 C  CZ  . ARG A 1 133 ? 38.29141  14.26361  -4.65560  1.000 54.21452  ?  133  ARG A CZ  1 
ATOM   1006 N  NH1 . ARG A 1 133 ? 37.92771  14.77072  -5.82994  1.000 47.33324  ?  133  ARG A NH1 1 
ATOM   1007 N  NH2 . ARG A 1 133 ? 39.42853  14.68019  -4.09629  1.000 54.55275  ?  133  ARG A NH2 1 
ATOM   1008 N  N   . ARG A 1 134 ? 35.09305  8.40642   -3.46849  1.000 39.16075  ?  134  ARG A N   1 
ATOM   1009 C  CA  . ARG A 1 134 ? 36.09788  7.48243   -2.94247  1.000 37.61774  ?  134  ARG A CA  1 
ATOM   1010 C  C   . ARG A 1 134 ? 36.59437  6.55122   -4.03393  1.000 37.92280  ?  134  ARG A C   1 
ATOM   1011 O  O   . ARG A 1 134 ? 37.79695  6.27008   -4.12469  1.000 40.25138  ?  134  ARG A O   1 
ATOM   1012 C  CB  . ARG A 1 134 ? 35.53988  6.68526   -1.75898  1.000 33.90817  ?  134  ARG A CB  1 
ATOM   1013 C  CG  . ARG A 1 134 ? 35.14896  7.56835   -0.55325  1.000 35.21587  ?  134  ARG A CG  1 
ATOM   1014 C  CD  . ARG A 1 134 ? 35.07325  6.80891   0.76173   1.000 36.18921  ?  134  ARG A CD  1 
ATOM   1015 N  NE  . ARG A 1 134 ? 35.97802  5.65901   0.82923   1.000 31.17444  ?  134  ARG A NE  1 
ATOM   1016 C  CZ  . ARG A 1 134 ? 35.74231  4.60738   1.60362   1.000 34.61057  ?  134  ARG A CZ  1 
ATOM   1017 N  NH1 . ARG A 1 134 ? 34.66369  4.54566   2.36889   1.000 35.97668  ?  134  ARG A NH1 1 
ATOM   1018 N  NH2 . ARG A 1 134 ? 36.60741  3.59649   1.61697   1.000 35.94383  ?  134  ARG A NH2 1 
ATOM   1019 N  N   . LEU A 1 135 ? 35.69330  6.07950   -4.89233  1.000 35.63443  ?  135  LEU A N   1 
ATOM   1020 C  CA  . LEU A 1 135 ? 36.14817  5.17527   -5.93687  1.000 37.39426  ?  135  LEU A CA  1 
ATOM   1021 C  C   . LEU A 1 135 ? 36.96972  5.91903   -6.98250  1.000 42.86741  ?  135  LEU A C   1 
ATOM   1022 O  O   . LEU A 1 135 ? 37.96113  5.38719   -7.50109  1.000 40.20881  ?  135  LEU A O   1 
ATOM   1023 C  CB  . LEU A 1 135 ? 34.96068  4.46660   -6.56693  1.000 39.72712  ?  135  LEU A CB  1 
ATOM   1024 C  CG  . LEU A 1 135 ? 34.38577  3.35706   -5.68264  1.000 37.23730  ?  135  LEU A CG  1 
ATOM   1025 C  CD1 . LEU A 1 135 ? 32.97804  3.03037   -6.15595  1.000 34.21236  ?  135  LEU A CD1 1 
ATOM   1026 C  CD2 . LEU A 1 135 ? 35.26441  2.09648   -5.72079  1.000 36.56931  ?  135  LEU A CD2 1 
ATOM   1027 N  N   . GLN A 1 136 ? 36.59657  7.16408   -7.28609  1.000 43.00635  ?  136  GLN A N   1 
ATOM   1028 C  CA  . GLN A 1 136 ? 37.33069  7.86001   -8.32975  1.000 43.25788  ?  136  GLN A CA  1 
ATOM   1029 C  C   . GLN A 1 136 ? 38.72767  8.25021   -7.87577  1.000 45.53351  ?  136  GLN A C   1 
ATOM   1030 O  O   . GLN A 1 136 ? 39.59387  8.49992   -8.72060  1.000 48.98544  ?  136  GLN A O   1 
ATOM   1031 C  CB  . GLN A 1 136 ? 36.49995  9.04690   -8.80949  1.000 40.39264  ?  136  GLN A CB  1 
ATOM   1032 C  CG  . GLN A 1 136 ? 35.52864  8.60885   -9.92800  1.000 50.92032  ?  136  GLN A CG  1 
ATOM   1033 C  CD  . GLN A 1 136 ? 34.86769  7.18108   -9.72208  1.000 57.95175  ?  136  GLN A CD  1 
ATOM   1034 O  OE1 . GLN A 1 136 ? 33.78595  7.05378   -9.10514  1.000 46.01207  ?  136  GLN A OE1 1 
ATOM   1035 N  NE2 . GLN A 1 136 ? 35.53256  6.12148   -10.24074 1.000 44.00575  ?  136  GLN A NE2 1 
ATOM   1036 N  N   . GLN A 1 137 ? 38.99404  8.18873   -6.57256  1.000 44.05567  ?  137  GLN A N   1 
ATOM   1037 C  CA  . GLN A 1 137 ? 40.27110  8.58534   -6.00564  1.000 41.61477  ?  137  GLN A CA  1 
ATOM   1038 C  C   . GLN A 1 137 ? 41.08917  7.39551   -5.50457  1.000 44.22495  ?  137  GLN A C   1 
ATOM   1039 O  O   . GLN A 1 137 ? 42.04311  7.58714   -4.75074  1.000 42.61352  ?  137  GLN A O   1 
ATOM   1040 C  CB  . GLN A 1 137 ? 40.02779  9.58913   -4.88285  1.000 36.92653  ?  137  GLN A CB  1 
ATOM   1041 C  CG  . GLN A 1 137 ? 39.59953  10.98273  -5.38814  1.000 45.73047  ?  137  GLN A CG  1 
ATOM   1042 C  CD  . GLN A 1 137 ? 40.39137  11.45157  -6.62973  1.000 56.49623  ?  137  GLN A CD  1 
ATOM   1043 O  OE1 . GLN A 1 137 ? 41.54872  11.87652  -6.52789  1.000 55.93266  ?  137  GLN A OE1 1 
ATOM   1044 N  NE2 . GLN A 1 137 ? 39.75311  11.39169  -7.80000  1.000 57.48107  ?  137  GLN A NE2 1 
ATOM   1045 N  N   . ALA A 1 138 ? 40.76906  6.17119   -5.93508  1.000 37.62433  ?  138  ALA A N   1 
ATOM   1046 C  CA  . ALA A 1 138 ? 41.31886  4.97857   -5.30091  1.000 38.04193  ?  138  ALA A CA  1 
ATOM   1047 C  C   . ALA A 1 138 ? 42.39862  4.27214   -6.11659  1.000 42.27374  ?  138  ALA A C   1 
ATOM   1048 O  O   . ALA A 1 138 ? 42.74881  3.13234   -5.79056  1.000 40.14990  ?  138  ALA A O   1 
ATOM   1049 C  CB  . ALA A 1 138 ? 40.18945  3.98869   -4.98611  1.000 38.73732  ?  138  ALA A CB  1 
ATOM   1050 N  N   . ASP A 1 139 ? 42.93966  4.89992   -7.16438  1.000 42.84211  ?  139  ASP A N   1 
ATOM   1051 C  CA  . ASP A 1 139 ? 43.86197  4.17194   -8.03466  1.000 42.29145  ?  139  ASP A CA  1 
ATOM   1052 C  C   . ASP A 1 139 ? 45.14769  3.79150   -7.30526  1.000 43.29263  ?  139  ASP A C   1 
ATOM   1053 O  O   . ASP A 1 139 ? 45.62691  2.65780   -7.44197  1.000 43.48868  ?  139  ASP A O   1 
ATOM   1054 C  CB  . ASP A 1 139 ? 44.16500  4.98531   -9.29064  1.000 46.45131  ?  139  ASP A CB  1 
ATOM   1055 C  CG  . ASP A 1 139 ? 43.02229  4.93794   -10.31912 1.000 51.88641  ?  139  ASP A CG  1 
ATOM   1056 O  OD1 . ASP A 1 139 ? 42.28748  3.91688   -10.35805 1.000 48.68897  -1 139  ASP A OD1 1 
ATOM   1057 O  OD2 . ASP A 1 139 ? 42.88831  5.91970   -11.10019 1.000 53.94028  -1 139  ASP A OD2 1 
ATOM   1058 N  N   . ASP A 1 140 ? 45.69919  4.71466   -6.50917  1.000 40.49951  ?  140  ASP A N   1 
ATOM   1059 C  CA  . ASP A 1 140 ? 46.95926  4.47245   -5.80418  1.000 42.67553  ?  140  ASP A CA  1 
ATOM   1060 C  C   . ASP A 1 140 ? 46.81596  3.35942   -4.77351  1.000 44.86589  ?  140  ASP A C   1 
ATOM   1061 O  O   . ASP A 1 140 ? 47.66100  2.45284   -4.69536  1.000 40.00114  ?  140  ASP A O   1 
ATOM   1062 C  CB  . ASP A 1 140 ? 47.41896  5.75710   -5.11424  1.000 46.78788  ?  140  ASP A CB  1 
ATOM   1063 C  CG  . ASP A 1 140 ? 48.12892  6.71446   -6.05727  1.000 58.23096  ?  140  ASP A CG  1 
ATOM   1064 O  OD1 . ASP A 1 140 ? 47.62722  6.95035   -7.18538  1.000 59.55646  -1 140  ASP A OD1 1 
ATOM   1065 O  OD2 . ASP A 1 140 ? 49.17813  7.26299   -5.65546  1.000 68.76137  -1 140  ASP A OD2 1 
ATOM   1066 N  N   . GLU A 1 141 ? 45.77114  3.44654   -3.93720  1.000 39.64060  ?  141  GLU A N   1 
ATOM   1067 C  CA  . GLU A 1 141 ? 45.52546  2.42267   -2.92663  1.000 40.01449  ?  141  GLU A CA  1 
ATOM   1068 C  C   . GLU A 1 141 ? 45.40371  1.04525   -3.56654  1.000 42.51322  ?  141  GLU A C   1 
ATOM   1069 O  O   . GLU A 1 141 ? 45.99839  0.07039   -3.08777  1.000 41.82844  ?  141  GLU A O   1 
ATOM   1070 C  CB  . GLU A 1 141 ? 44.26112  2.76888   -2.13307  1.000 37.75269  ?  141  GLU A CB  1 
ATOM   1071 C  CG  . GLU A 1 141 ? 43.91272  1.76583   -1.02612  1.000 42.87933  ?  141  GLU A CG  1 
ATOM   1072 C  CD  . GLU A 1 141 ? 42.65073  2.14911   -0.24022  1.000 44.46791  ?  141  GLU A CD  1 
ATOM   1073 O  OE1 . GLU A 1 141 ? 42.41679  3.36193   -0.01836  1.000 41.41317  ?  141  GLU A OE1 1 
ATOM   1074 O  OE2 . GLU A 1 141 ? 41.90486  1.23414   0.17042   1.000 38.36503  -1 141  GLU A OE2 1 
ATOM   1075 N  N   . LEU A 1 142 ? 44.65975  0.94766   -4.66769  1.000 42.12018  ?  142  LEU A N   1 
ATOM   1076 C  CA  . LEU A 1 142 ? 44.54565  -0.33577  -5.34473  1.000 40.71835  ?  142  LEU A CA  1 
ATOM   1077 C  C   . LEU A 1 142 ? 45.90579  -0.81382  -5.81568  1.000 41.68265  ?  142  LEU A C   1 
ATOM   1078 O  O   . LEU A 1 142 ? 46.28394  -1.96662  -5.56741  1.000 36.63606  ?  142  LEU A O   1 
ATOM   1079 C  CB  . LEU A 1 142 ? 43.57204  -0.24984  -6.52750  1.000 34.71884  ?  142  LEU A CB  1 
ATOM   1080 C  CG  . LEU A 1 142 ? 43.32914  -1.62036  -7.18007  1.000 37.94301  ?  142  LEU A CG  1 
ATOM   1081 C  CD1 . LEU A 1 142 ? 43.12835  -2.74086  -6.11120  1.000 32.72169  ?  142  LEU A CD1 1 
ATOM   1082 C  CD2 . LEU A 1 142 ? 42.16150  -1.60138  -8.21196  1.000 31.84491  ?  142  LEU A CD2 1 
ATOM   1083 N  N   . ALA A 1 143 ? 46.65799  0.06240   -6.50382  1.000 41.71473  ?  143  ALA A N   1 
ATOM   1084 C  CA  . ALA A 1 143 ? 47.90534  -0.38064  -7.13023  1.000 43.68565  ?  143  ALA A CA  1 
ATOM   1085 C  C   . ALA A 1 143 ? 48.90079  -0.84498  -6.08140  1.000 40.24897  ?  143  ALA A C   1 
ATOM   1086 O  O   . ALA A 1 143 ? 49.55544  -1.89046  -6.24712  1.000 39.82853  ?  143  ALA A O   1 
ATOM   1087 C  CB  . ALA A 1 143 ? 48.49215  0.73511   -7.99700  1.000 47.25923  ?  143  ALA A CB  1 
ATOM   1088 N  N   . ALA A 1 144 ? 48.99029  -0.10276  -4.97125  1.000 38.28458  ?  144  ALA A N   1 
ATOM   1089 C  CA  . ALA A 1 144 ? 49.83886  -0.51049  -3.85424  1.000 43.70216  ?  144  ALA A CA  1 
ATOM   1090 C  C   . ALA A 1 144 ? 49.36276  -1.82986  -3.23662  1.000 46.70822  ?  144  ALA A C   1 
ATOM   1091 O  O   . ALA A 1 144 ? 50.17890  -2.69674  -2.88183  1.000 46.60321  ?  144  ALA A O   1 
ATOM   1092 C  CB  . ALA A 1 144 ? 49.88719  0.60089   -2.80732  1.000 36.57197  ?  144  ALA A CB  1 
ATOM   1093 N  N   . SER A 1 145 ? 48.04684  -2.01411  -3.10815  1.000 41.89139  ?  145  SER A N   1 
ATOM   1094 C  CA  . SER A 1 145 ? 47.56601  -3.25951  -2.52416  1.000 40.08904  ?  145  SER A CA  1 
ATOM   1095 C  C   . SER A 1 145 ? 47.91228  -4.44112  -3.41013  1.000 41.11133  ?  145  SER A C   1 
ATOM   1096 O  O   . SER A 1 145 ? 48.28311  -5.51619  -2.91793  1.000 39.52864  ?  145  SER A O   1 
ATOM   1097 C  CB  . SER A 1 145 ? 46.05751  -3.18232  -2.29338  1.000 38.48351  ?  145  SER A CB  1 
ATOM   1098 O  OG  . SER A 1 145 ? 45.75178  -2.07175  -1.47614  1.000 38.25892  ?  145  SER A OG  1 
ATOM   1099 N  N   . LEU A 1 146 ? 47.79292  -4.25927  -4.72351  1.000 40.03003  ?  146  LEU A N   1 
ATOM   1100 C  CA  . LEU A 1 146 ? 48.07660  -5.36035  -5.63215  1.000 41.20319  ?  146  LEU A CA  1 
ATOM   1101 C  C   . LEU A 1 146 ? 49.57291  -5.64143  -5.67084  1.000 47.10859  ?  146  LEU A C   1 
ATOM   1102 O  O   . LEU A 1 146 ? 49.98796  -6.80595  -5.75333  1.000 44.70440  ?  146  LEU A O   1 
ATOM   1103 C  CB  . LEU A 1 146 ? 47.51051  -5.04845  -7.01979  1.000 41.68757  ?  146  LEU A CB  1 
ATOM   1104 C  CG  . LEU A 1 146 ? 45.97244  -5.08578  -7.05533  1.000 50.09204  ?  146  LEU A CG  1 
ATOM   1105 C  CD1 . LEU A 1 146 ? 45.39112  -4.57857  -8.40125  1.000 43.27805  ?  146  LEU A CD1 1 
ATOM   1106 C  CD2 . LEU A 1 146 ? 45.41967  -6.49006  -6.68984  1.000 36.51105  ?  146  LEU A CD2 1 
ATOM   1107 N  N   . SER A 1 147 ? 50.39523  -4.58669  -5.60327  1.000 38.80547  ?  147  SER A N   1 
ATOM   1108 C  CA  . SER A 1 147 ? 51.82927  -4.76533  -5.42298  1.000 41.59430  ?  147  SER A CA  1 
ATOM   1109 C  C   . SER A 1 147 ? 52.09130  -5.69553  -4.25284  1.000 48.99587  ?  147  SER A C   1 
ATOM   1110 O  O   . SER A 1 147 ? 52.72771  -6.74867  -4.40093  1.000 49.08250  ?  147  SER A O   1 
ATOM   1111 C  CB  . SER A 1 147 ? 52.51177  -3.41925  -5.17086  1.000 45.86204  ?  147  SER A CB  1 
ATOM   1112 O  OG  . SER A 1 147 ? 53.20392  -2.95327  -6.30708  1.000 55.80975  ?  147  SER A OG  1 
ATOM   1113 N  N   . GLY A 1 148 ? 51.56721  -5.32191  -3.07894  1.000 45.03444  ?  148  GLY A N   1 
ATOM   1114 C  CA  . GLY A 1 148 ? 51.77899  -6.13761  -1.89436  1.000 43.68574  ?  148  GLY A CA  1 
ATOM   1115 C  C   . GLY A 1 148 ? 51.29887  -7.56223  -2.07647  1.000 43.87194  ?  148  GLY A C   1 
ATOM   1116 O  O   . GLY A 1 148 ? 51.98363  -8.51242  -1.69880  1.000 52.67471  ?  148  GLY A O   1 
ATOM   1117 N  N   . PHE A 1 149 ? 50.12413  -7.73171  -2.67408  1.000 47.10074  ?  149  PHE A N   1 
ATOM   1118 C  CA  . PHE A 1 149 ? 49.58252  -9.07174  -2.85431  1.000 46.72381  ?  149  PHE A CA  1 
ATOM   1119 C  C   . PHE A 1 149 ? 50.47611  -9.91383  -3.75962  1.000 52.05648  ?  149  PHE A C   1 
ATOM   1120 O  O   . PHE A 1 149 ? 50.71413  -11.09406 -3.48143  1.000 52.18680  ?  149  PHE A O   1 
ATOM   1121 C  CB  . PHE A 1 149 ? 48.16850  -8.99300  -3.42688  1.000 46.66452  ?  149  PHE A CB  1 
ATOM   1122 C  CG  . PHE A 1 149 ? 47.57821  -10.33266 -3.75653  1.000 50.88245  ?  149  PHE A CG  1 
ATOM   1123 C  CD1 . PHE A 1 149 ? 47.32045  -11.25972 -2.75958  1.000 49.18024  ?  149  PHE A CD1 1 
ATOM   1124 C  CD2 . PHE A 1 149 ? 47.33060  -10.68972 -5.07740  1.000 55.69679  ?  149  PHE A CD2 1 
ATOM   1125 C  CE1 . PHE A 1 149 ? 46.77282  -12.51187 -3.06580  1.000 55.07063  ?  149  PHE A CE1 1 
ATOM   1126 C  CE2 . PHE A 1 149 ? 46.79423  -11.94736 -5.39750  1.000 58.43176  ?  149  PHE A CE2 1 
ATOM   1127 C  CZ  . PHE A 1 149 ? 46.51911  -12.86008 -4.38290  1.000 55.58419  ?  149  PHE A CZ  1 
ATOM   1128 N  N   . VAL A 1 150 ? 50.96188  -9.33031  -4.86052  1.000 53.51484  ?  150  VAL A N   1 
ATOM   1129 C  CA  . VAL A 1 150 ? 51.82748  -10.06240 -5.78978  1.000 57.68038  ?  150  VAL A CA  1 
ATOM   1130 C  C   . VAL A 1 150 ? 53.14058  -10.43877 -5.10798  1.000 57.93139  ?  150  VAL A C   1 
ATOM   1131 O  O   . VAL A 1 150 ? 53.61052  -11.58310 -5.20733  1.000 56.32848  ?  150  VAL A O   1 
ATOM   1132 C  CB  . VAL A 1 150 ? 52.05786  -9.22620  -7.06680  1.000 55.46365  ?  150  VAL A CB  1 
ATOM   1133 C  CG1 . VAL A 1 150 ? 53.34196  -9.66128  -7.78561  1.000 55.98026  ?  150  VAL A CG1 1 
ATOM   1134 C  CG2 . VAL A 1 150 ? 50.85885  -9.34214  -7.99443  1.000 47.42125  ?  150  VAL A CG2 1 
ATOM   1135 N  N   . GLU A 1 151 ? 53.72428  -9.48405  -4.37359  1.000 55.81922  ?  151  GLU A N   1 
ATOM   1136 C  CA  . GLU A 1 151 ? 54.92802  -9.72024  -3.58635  1.000 56.68783  ?  151  GLU A CA  1 
ATOM   1137 C  C   . GLU A 1 151 ? 54.76159  -10.86744 -2.59984  1.000 57.68997  ?  151  GLU A C   1 
ATOM   1138 O  O   . GLU A 1 151 ? 55.73927  -11.54131 -2.26469  1.000 62.76004  ?  151  GLU A O   1 
ATOM   1139 C  CB  . GLU A 1 151 ? 55.29590  -8.43392  -2.84557  1.000 57.49666  ?  151  GLU A CB  1 
ATOM   1140 C  CG  . GLU A 1 151 ? 56.29149  -8.62798  -1.71859  1.000 69.41495  ?  151  GLU A CG  1 
ATOM   1141 C  CD  . GLU A 1 151 ? 57.29437  -7.49143  -1.62000  1.000 81.42724  ?  151  GLU A CD  1 
ATOM   1142 O  OE1 . GLU A 1 151 ? 58.43382  -7.66659  -2.11264  1.000 84.98652  ?  151  GLU A OE1 1 
ATOM   1143 O  OE2 . GLU A 1 151 ? 56.94638  -6.43235  -1.04361  1.000 80.21425  -1 151  GLU A OE2 1 
ATOM   1144 N  N   . SER A 1 152 ? 53.54442  -11.09913 -2.11851  1.000 59.67892  ?  152  SER A N   1 
ATOM   1145 C  CA  . SER A 1 152 ? 53.28061  -12.11260 -1.11308  1.000 55.24821  ?  152  SER A CA  1 
ATOM   1146 C  C   . SER A 1 152 ? 53.21391  -13.49787 -1.75018  1.000 61.07466  ?  152  SER A C   1 
ATOM   1147 O  O   . SER A 1 152 ? 53.36309  -13.67249 -2.96435  1.000 62.89584  ?  152  SER A O   1 
ATOM   1148 C  CB  . SER A 1 152 ? 51.98529  -11.79110 -0.36890  1.000 60.44438  ?  152  SER A CB  1 
ATOM   1149 O  OG  . SER A 1 152 ? 50.86580  -12.37690 -1.00990  1.000 56.44919  ?  152  SER A OG  1 
ATOM   1150 N  N   . SER A 1 153 ? 52.96906  -14.49668 -0.90620  1.000 64.52384  ?  153  SER A N   1 
ATOM   1151 C  CA  . SER A 1 153 ? 53.00980  -15.90331 -1.29233  1.000 69.85332  ?  153  SER A CA  1 
ATOM   1152 C  C   . SER A 1 153 ? 51.70629  -16.41852 -1.88863  1.000 68.29813  ?  153  SER A C   1 
ATOM   1153 O  O   . SER A 1 153 ? 51.69333  -17.52014 -2.45372  1.000 68.56441  ?  153  SER A O   1 
ATOM   1154 C  CB  . SER A 1 153 ? 53.36184  -16.77084 -0.07111  1.000 66.78081  ?  153  SER A CB  1 
ATOM   1155 O  OG  . SER A 1 153 ? 52.23828  -16.91145 0.78618   1.000 58.53557  ?  153  SER A OG  1 
ATOM   1156 N  N   . LEU A 1 154 ? 50.62016  -15.66592 -1.77698  1.000 63.47954  ?  154  LEU A N   1 
ATOM   1157 C  CA  . LEU A 1 154 ? 49.31308  -16.25126 -1.98316  1.000 59.86738  ?  154  LEU A CA  1 
ATOM   1158 C  C   . LEU A 1 154 ? 49.10383  -16.58923 -3.45764  1.000 61.23727  ?  154  LEU A C   1 
ATOM   1159 O  O   . LEU A 1 154 ? 49.60487  -15.88768 -4.33942  1.000 62.79307  ?  154  LEU A O   1 
ATOM   1160 C  CB  . LEU A 1 154 ? 48.23874  -15.30336 -1.46830  1.000 60.65388  ?  154  LEU A CB  1 
ATOM   1161 C  CG  . LEU A 1 154 ? 48.78101  -14.57581 -0.23117  1.000 59.50940  ?  154  LEU A CG  1 
ATOM   1162 C  CD1 . LEU A 1 154 ? 47.98578  -13.34571 0.05248   1.000 63.11551  ?  154  LEU A CD1 1 
ATOM   1163 C  CD2 . LEU A 1 154 ? 48.84552  -15.45150 0.99357   1.000 57.56551  ?  154  LEU A CD2 1 
ATOM   1164 N  N   . PRO A 1 155 ? 48.38512  -17.67521 -3.74996  1.000 58.07521  ?  155  PRO A N   1 
ATOM   1165 C  CA  . PRO A 1 155 ? 48.24567  -18.11269 -5.14329  1.000 58.23115  ?  155  PRO A CA  1 
ATOM   1166 C  C   . PRO A 1 155 ? 47.56777  -17.04631 -5.98493  1.000 63.73881  ?  155  PRO A C   1 
ATOM   1167 O  O   . PRO A 1 155 ? 46.87128  -16.16507 -5.47317  1.000 56.73660  ?  155  PRO A O   1 
ATOM   1168 C  CB  . PRO A 1 155 ? 47.37842  -19.37245 -5.04531  1.000 58.68284  ?  155  PRO A CB  1 
ATOM   1169 C  CG  . PRO A 1 155 ? 46.65593  -19.24477 -3.74601  1.000 60.69385  ?  155  PRO A CG  1 
ATOM   1170 C  CD  . PRO A 1 155 ? 47.57675  -18.48682 -2.82408  1.000 58.52087  ?  155  PRO A CD  1 
ATOM   1171 N  N   . GLU A 1 156 ? 47.79066  -17.13933 -7.30231  1.000 65.98864  ?  156  GLU A N   1 
ATOM   1172 C  CA  . GLU A 1 156 ? 47.25503  -16.13933 -8.22341  1.000 67.35032  ?  156  GLU A CA  1 
ATOM   1173 C  C   . GLU A 1 156 ? 45.73917  -16.05268 -8.12103  1.000 63.93771  ?  156  GLU A C   1 
ATOM   1174 O  O   . GLU A 1 156 ? 45.17396  -14.95114 -8.10924  1.000 61.69189  ?  156  GLU A O   1 
ATOM   1175 C  CB  . GLU A 1 156 ? 47.68540  -16.45219 -9.66362  1.000 68.99916  ?  156  GLU A CB  1 
ATOM   1176 C  CG  . GLU A 1 156 ? 46.75213  -15.90448 -10.77316 1.000 74.73289  ?  156  GLU A CG  1 
ATOM   1177 C  CD  . GLU A 1 156 ? 46.82473  -14.37705 -10.98018 1.000 82.98613  ?  156  GLU A CD  1 
ATOM   1178 O  OE1 . GLU A 1 156 ? 46.94864  -13.62759 -9.98045  1.000 83.14906  ?  156  GLU A OE1 1 
ATOM   1179 O  OE2 . GLU A 1 156 ? 46.74082  -13.92654 -12.15252 1.000 75.79342  -1 156  GLU A OE2 1 
ATOM   1180 N  N   . ASP A 1 157 ? 45.06646  -17.20094 -8.01172  1.000 60.19110  ?  157  ASP A N   1 
ATOM   1181 C  CA  . ASP A 1 157 ? 43.61249  -17.23948 -7.93670  1.000 64.17586  ?  157  ASP A CA  1 
ATOM   1182 C  C   . ASP A 1 157 ? 43.09185  -17.13240 -6.50814  1.000 59.03630  ?  157  ASP A C   1 
ATOM   1183 O  O   . ASP A 1 157 ? 42.00748  -17.65893 -6.20950  1.000 58.19111  ?  157  ASP A O   1 
ATOM   1184 C  CB  . ASP A 1 157 ? 43.08130  -18.51045 -8.60379  1.000 65.48594  ?  157  ASP A CB  1 
ATOM   1185 C  CG  . ASP A 1 157 ? 43.46240  -19.77239 -7.85211  1.000 69.15494  ?  157  ASP A CG  1 
ATOM   1186 O  OD1 . ASP A 1 157 ? 44.24389  -19.68865 -6.87549  1.000 59.61622  ?  157  ASP A OD1 1 
ATOM   1187 O  OD2 . ASP A 1 157 ? 42.97371  -20.85784 -8.24420  1.000 76.22812  -1 157  ASP A OD2 1 
ATOM   1188 N  N   . PHE A 1 158 ? 43.84916  -16.49503 -5.60981  1.000 51.27287  ?  158  PHE A N   1 
ATOM   1189 C  CA  . PHE A 1 158 ? 43.34509  -16.27193 -4.26196  1.000 54.84883  ?  158  PHE A CA  1 
ATOM   1190 C  C   . PHE A 1 158 ? 42.03433  -15.48549 -4.28073  1.000 54.12686  ?  158  PHE A C   1 
ATOM   1191 O  O   . PHE A 1 158 ? 41.20993  -15.63843 -3.37441  1.000 51.50040  ?  158  PHE A O   1 
ATOM   1192 C  CB  . PHE A 1 158 ? 44.39634  -15.55427 -3.41680  1.000 51.30763  ?  158  PHE A CB  1 
ATOM   1193 C  CG  . PHE A 1 158 ? 43.97259  -15.32705 -1.99172  1.000 50.12874  ?  158  PHE A CG  1 
ATOM   1194 C  CD1 . PHE A 1 158 ? 44.20318  -16.28801 -1.02747  1.000 48.43852  ?  158  PHE A CD1 1 
ATOM   1195 C  CD2 . PHE A 1 158 ? 43.34896  -14.14560 -1.61776  1.000 48.35015  ?  158  PHE A CD2 1 
ATOM   1196 C  CE1 . PHE A 1 158 ? 43.82884  -16.08803 0.29371   1.000 51.80876  ?  158  PHE A CE1 1 
ATOM   1197 C  CE2 . PHE A 1 158 ? 42.96267  -13.92748 -0.29635  1.000 50.59340  ?  158  PHE A CE2 1 
ATOM   1198 C  CZ  . PHE A 1 158 ? 43.20232  -14.91009 0.66712   1.000 50.68153  ?  158  PHE A CZ  1 
ATOM   1199 N  N   . PHE A 1 159 ? 41.81423  -14.65920 -5.31241  1.000 54.79283  ?  159  PHE A N   1 
ATOM   1200 C  CA  . PHE A 1 159 ? 40.56150  -13.93484 -5.51138  1.000 51.18334  ?  159  PHE A CA  1 
ATOM   1201 C  C   . PHE A 1 159 ? 39.92171  -14.43492 -6.79892  1.000 53.66198  ?  159  PHE A C   1 
ATOM   1202 O  O   . PHE A 1 159 ? 40.06366  -13.80544 -7.85936  1.000 56.68490  ?  159  PHE A O   1 
ATOM   1203 C  CB  . PHE A 1 159 ? 40.77231  -12.42690 -5.58628  1.000 46.92271  ?  159  PHE A CB  1 
ATOM   1204 C  CG  . PHE A 1 159 ? 41.41770  -11.83671 -4.37342  1.000 50.52671  ?  159  PHE A CG  1 
ATOM   1205 C  CD1 . PHE A 1 159 ? 40.70972  -11.70656 -3.18618  1.000 46.59413  ?  159  PHE A CD1 1 
ATOM   1206 C  CD2 . PHE A 1 159 ? 42.73198  -11.37962 -4.42540  1.000 50.36766  ?  159  PHE A CD2 1 
ATOM   1207 C  CE1 . PHE A 1 159 ? 41.30788  -11.12800 -2.05924  1.000 43.98872  ?  159  PHE A CE1 1 
ATOM   1208 C  CE2 . PHE A 1 159 ? 43.33911  -10.81024 -3.30438  1.000 45.79358  ?  159  PHE A CE2 1 
ATOM   1209 C  CZ  . PHE A 1 159 ? 42.62510  -10.67770 -2.12451  1.000 41.43425  ?  159  PHE A CZ  1 
ATOM   1210 N  N   . PRO A 1 160 ? 39.18495  -15.53767 -6.74005  1.000 54.26178  ?  160  PRO A N   1 
ATOM   1211 C  CA  . PRO A 1 160 ? 38.51431  -16.09005 -7.94046  1.000 58.30749  ?  160  PRO A CA  1 
ATOM   1212 C  C   . PRO A 1 160 ? 37.19245  -15.39870 -8.26314  1.000 58.20249  ?  160  PRO A C   1 
ATOM   1213 O  O   . PRO A 1 160 ? 36.10271  -15.95889 -8.12157  1.000 63.31840  ?  160  PRO A O   1 
ATOM   1214 C  CB  . PRO A 1 160 ? 38.32330  -17.56462 -7.55973  1.000 53.68279  ?  160  PRO A CB  1 
ATOM   1215 C  CG  . PRO A 1 160 ? 38.64538  -17.68355 -6.07558  1.000 57.06965  ?  160  PRO A CG  1 
ATOM   1216 C  CD  . PRO A 1 160 ? 38.88660  -16.31906 -5.53188  1.000 54.15835  ?  160  PRO A CD  1 
ATOM   1217 N  N   . LEU A 1 161 ? 37.26464  -14.15351 -8.72765  1.000 52.72055  ?  161  LEU A N   1 
ATOM   1218 C  CA  . LEU A 1 161 ? 36.06311  -13.35047 -8.94954  1.000 50.31596  ?  161  LEU A CA  1 
ATOM   1219 C  C   . LEU A 1 161 ? 35.46013  -13.66566 -10.31253 1.000 50.73260  ?  161  LEU A C   1 
ATOM   1220 O  O   . LEU A 1 161 ? 36.09778  -13.43945 -11.34947 1.000 57.92885  ?  161  LEU A O   1 
ATOM   1221 C  CB  . LEU A 1 161 ? 36.38815  -11.86147 -8.85127  1.000 50.30145  ?  161  LEU A CB  1 
ATOM   1222 C  CG  . LEU A 1 161 ? 37.05844  -11.38147 -7.55832  1.000 50.58058  ?  161  LEU A CG  1 
ATOM   1223 C  CD1 . LEU A 1 161 ? 36.81639  -9.89970  -7.41756  1.000 48.62758  ?  161  LEU A CD1 1 
ATOM   1224 C  CD2 . LEU A 1 161 ? 36.55479  -12.12026 -6.31853  1.000 48.01663  ?  161  LEU A CD2 1 
ATOM   1225 N  N   . SER A 1 162 ? 34.22360  -14.15786 -10.31672 1.000 44.48729  ?  162  SER A N   1 
ATOM   1226 C  CA  . SER A 1 162 ? 33.57404  -14.62656 -11.53314 1.000 46.65542  ?  162  SER A CA  1 
ATOM   1227 C  C   . SER A 1 162 ? 32.20304  -13.98663 -11.66812 1.000 48.68151  ?  162  SER A C   1 
ATOM   1228 O  O   . SER A 1 162 ? 31.32958  -14.18747 -10.81378 1.000 47.10114  ?  162  SER A O   1 
ATOM   1229 C  CB  . SER A 1 162 ? 33.43979  -16.14690 -11.54176 1.000 44.33783  ?  162  SER A CB  1 
ATOM   1230 O  OG  . SER A 1 162 ? 32.37881  -16.52153 -12.40555 1.000 47.48578  ?  162  SER A OG  1 
ATOM   1231 N  N   . ASP A 1 163 ? 32.01207  -13.24300 -12.75911 1.000 45.49062  ?  163  ASP A N   1 
ATOM   1232 C  CA  . ASP A 1 163 ? 30.70825  -12.66838 -13.05584 1.000 43.94813  ?  163  ASP A CA  1 
ATOM   1233 C  C   . ASP A 1 163 ? 29.64579  -13.75688 -13.14763 1.000 44.07794  ?  163  ASP A C   1 
ATOM   1234 O  O   . ASP A 1 163 ? 28.54654  -13.60633 -12.60654 1.000 39.85033  ?  163  ASP A O   1 
ATOM   1235 C  CB  . ASP A 1 163 ? 30.77072  -11.89267 -14.37508 1.000 45.89757  ?  163  ASP A CB  1 
ATOM   1236 C  CG  . ASP A 1 163 ? 31.09625  -10.40889 -14.18703 1.000 55.22629  ?  163  ASP A CG  1 
ATOM   1237 O  OD1 . ASP A 1 163 ? 31.82283  -9.85529  -15.05853 1.000 55.32168  -1 163  ASP A OD1 1 
ATOM   1238 O  OD2 . ASP A 1 163 ? 30.65215  -9.80258  -13.18257 1.000 48.66930  ?  163  ASP A OD2 1 
ATOM   1239 N  N   . ASP A 1 164 ? 29.95415  -14.86157 -13.82861 1.000 41.90668  ?  164  ASP A N   1 
ATOM   1240 C  CA  . ASP A 1 164 ? 28.92281  -15.86364 -14.11244 1.000 44.70929  ?  164  ASP A CA  1 
ATOM   1241 C  C   . ASP A 1 164 ? 28.37432  -16.48954 -12.83601 1.000 40.40121  ?  164  ASP A C   1 
ATOM   1242 O  O   . ASP A 1 164 ? 27.15306  -16.66955 -12.69746 1.000 41.00395  ?  164  ASP A O   1 
ATOM   1243 C  CB  . ASP A 1 164 ? 29.47863  -16.94103 -15.04211 1.000 44.88886  ?  164  ASP A CB  1 
ATOM   1244 C  CG  . ASP A 1 164 ? 29.52406  -16.49045 -16.49731 1.000 59.57955  ?  164  ASP A CG  1 
ATOM   1245 O  OD1 . ASP A 1 164 ? 29.06700  -15.35896 -16.80101 1.000 60.01877  ?  164  ASP A OD1 1 
ATOM   1246 O  OD2 . ASP A 1 164 ? 30.02922  -17.26508 -17.34208 1.000 70.07336  -1 164  ASP A OD2 1 
ATOM   1247 N  N   . ASP A 1 165 ? 29.26402  -16.82304 -11.88782 1.000 43.60321  ?  165  ASP A N   1 
ATOM   1248 C  CA  . ASP A 1 165 ? 28.82501  -17.38424 -10.61229 1.000 41.67684  ?  165  ASP A CA  1 
ATOM   1249 C  C   . ASP A 1 165 ? 27.99191  -16.37732 -9.82554  1.000 38.38542  ?  165  ASP A C   1 
ATOM   1250 O  O   . ASP A 1 165 ? 26.98521  -16.74157 -9.20786  1.000 39.84290  ?  165  ASP A O   1 
ATOM   1251 C  CB  . ASP A 1 165 ? 30.03180  -17.84704 -9.79836  1.000 39.27923  ?  165  ASP A CB  1 
ATOM   1252 C  CG  . ASP A 1 165 ? 30.72165  -19.05173 -10.42000 1.000 51.99113  ?  165  ASP A CG  1 
ATOM   1253 O  OD1 . ASP A 1 165 ? 30.10619  -19.70498 -11.29311 1.000 53.64648  ?  165  ASP A OD1 1 
ATOM   1254 O  OD2 . ASP A 1 165 ? 31.87399  -19.35057 -10.04173 1.000 49.78010  -1 165  ASP A OD2 1 
ATOM   1255 N  N   . LEU A 1 166 ? 28.39611  -15.10673 -9.84449  1.000 33.98864  ?  166  LEU A N   1 
ATOM   1256 C  CA  . LEU A 1 166 ? 27.59404  -14.06841 -9.20761  1.000 42.03467  ?  166  LEU A CA  1 
ATOM   1257 C  C   . LEU A 1 166 ? 26.22291  -13.96315 -9.85616  1.000 37.71845  ?  166  LEU A C   1 
ATOM   1258 O  O   . LEU A 1 166 ? 25.21985  -13.83490 -9.15944  1.000 38.49692  ?  166  LEU A O   1 
ATOM   1259 C  CB  . LEU A 1 166 ? 28.31605  -12.72471 -9.27045  1.000 32.93165  ?  166  LEU A CB  1 
ATOM   1260 C  CG  . LEU A 1 166 ? 29.39511  -12.46887 -8.24117  1.000 38.49810  ?  166  LEU A CG  1 
ATOM   1261 C  CD1 . LEU A 1 166 ? 29.81121  -10.99730 -8.36858  1.000 36.01541  ?  166  LEU A CD1 1 
ATOM   1262 C  CD2 . LEU A 1 166 ? 28.87795  -12.79878 -6.82037  1.000 32.45754  ?  166  LEU A CD2 1 
ATOM   1263 N  N   . MET A 1 167 ? 26.17008  -13.99977 -11.18902 1.000 36.45858  ?  167  MET A N   1 
ATOM   1264 C  CA  . MET A 1 167 ? 24.90639  -14.03380 -11.91888 1.000 38.55730  ?  167  MET A CA  1 
ATOM   1265 C  C   . MET A 1 167 ? 23.99085  -15.13324 -11.39164 1.000 42.27072  ?  167  MET A C   1 
ATOM   1266 O  O   . MET A 1 167 ? 22.81165  -14.89673 -11.09559 1.000 39.79724  ?  167  MET A O   1 
ATOM   1267 C  CB  . MET A 1 167 ? 25.18577  -14.27496 -13.40693 1.000 36.44197  ?  167  MET A CB  1 
ATOM   1268 C  CG  . MET A 1 167 ? 24.23344  -13.65447 -14.40614 1.000 47.66436  ?  167  MET A CG  1 
ATOM   1269 S  SD  . MET A 1 167 ? 23.70880  -11.99092 -14.03568 1.000 67.51801  ?  167  MET A SD  1 
ATOM   1270 C  CE  . MET A 1 167 ? 25.14528  -11.08698 -14.65857 1.000 48.12657  ?  167  MET A CE  1 
ATOM   1271 N  N   . ARG A 1 168 ? 24.51714  -16.35682 -11.29344 1.000 38.40580  ?  168  ARG A N   1 
ATOM   1272 C  CA  . ARG A 1 168 ? 23.67050  -17.46255 -10.85953 1.000 39.06604  ?  168  ARG A CA  1 
ATOM   1273 C  C   . ARG A 1 168 ? 23.18028  -17.24556 -9.43284  1.000 36.04075  ?  168  ARG A C   1 
ATOM   1274 O  O   . ARG A 1 168 ? 21.99496  -17.42786 -9.13822  1.000 42.94775  ?  168  ARG A O   1 
ATOM   1275 C  CB  . ARG A 1 168 ? 24.42572  -18.78549 -10.97927 1.000 43.41497  ?  168  ARG A CB  1 
ATOM   1276 C  CG  . ARG A 1 168 ? 25.04561  -19.02250 -12.35147 1.000 52.90040  ?  168  ARG A CG  1 
ATOM   1277 C  CD  . ARG A 1 168 ? 25.12719  -20.50661 -12.71505 1.000 48.55363  ?  168  ARG A CD  1 
ATOM   1278 N  NE  . ARG A 1 168 ? 25.93232  -20.74356 -13.91243 1.000 64.91013  ?  168  ARG A NE  1 
ATOM   1279 C  CZ  . ARG A 1 168 ? 27.24992  -20.57253 -14.00673 1.000 64.99732  ?  168  ARG A CZ  1 
ATOM   1280 N  NH1 . ARG A 1 168 ? 27.98101  -20.17584 -12.97338 1.000 59.32827  ?  168  ARG A NH1 1 
ATOM   1281 N  NH2 . ARG A 1 168 ? 27.85302  -20.81027 -15.17056 1.000 67.70794  ?  168  ARG A NH2 1 
ATOM   1282 N  N   . ASP A 1 169 ? 24.07468  -16.83040 -8.53860  1.000 38.90194  ?  169  ASP A N   1 
ATOM   1283 C  CA  . ASP A 1 169 ? 23.67863  -16.60420 -7.15431  1.000 40.17760  ?  169  ASP A CA  1 
ATOM   1284 C  C   . ASP A 1 169 ? 22.64211  -15.48391 -7.05881  1.000 40.52254  ?  169  ASP A C   1 
ATOM   1285 O  O   . ASP A 1 169 ? 21.64253  -15.58329 -6.31965  1.000 39.01341  ?  169  ASP A O   1 
ATOM   1286 C  CB  . ASP A 1 169 ? 24.92336  -16.26280 -6.35220  1.000 36.71171  ?  169  ASP A CB  1 
ATOM   1287 C  CG  . ASP A 1 169 ? 24.91180  -16.86300 -4.97502  1.000 37.59225  ?  169  ASP A CG  1 
ATOM   1288 O  OD1 . ASP A 1 169 ? 24.74170  -18.09516 -4.85730  1.000 51.63038  ?  169  ASP A OD1 1 
ATOM   1289 O  OD2 . ASP A 1 169 ? 25.06991  -16.09382 -4.00592  1.000 40.71730  -1 169  ASP A OD2 1 
ATOM   1290 N  N   . PHE A 1 170 ? 22.85935  -14.42324 -7.83864  1.000 35.76573  ?  170  PHE A N   1 
ATOM   1291 C  CA  . PHE A 1 170 ? 21.97966  -13.26000 -7.84755  1.000 40.46609  ?  170  PHE A CA  1 
ATOM   1292 C  C   . PHE A 1 170 ? 20.58752  -13.65016 -8.29789  1.000 42.99018  ?  170  PHE A C   1 
ATOM   1293 O  O   . PHE A 1 170 ? 19.58929  -13.26407 -7.67649  1.000 41.65015  ?  170  PHE A O   1 
ATOM   1294 C  CB  . PHE A 1 170 ? 22.56925  -12.17667 -8.76709  1.000 34.56114  ?  170  PHE A CB  1 
ATOM   1295 C  CG  . PHE A 1 170 ? 21.71062  -10.93493 -8.89368  1.000 42.07783  ?  170  PHE A CG  1 
ATOM   1296 C  CD1 . PHE A 1 170 ? 21.78187  -9.93150  -7.95381  1.000 39.00640  ?  170  PHE A CD1 1 
ATOM   1297 C  CD2 . PHE A 1 170 ? 20.83715  -10.77818 -9.95756  1.000 45.32555  ?  170  PHE A CD2 1 
ATOM   1298 C  CE1 . PHE A 1 170 ? 20.98569  -8.78499  -8.06638  1.000 46.15494  ?  170  PHE A CE1 1 
ATOM   1299 C  CE2 . PHE A 1 170 ? 20.03801  -9.64685  -10.07168 1.000 45.77288  ?  170  PHE A CE2 1 
ATOM   1300 C  CZ  . PHE A 1 170 ? 20.11609  -8.65015  -9.13116  1.000 42.45554  ?  170  PHE A CZ  1 
ATOM   1301 N  N   . PHE A 1 171 ? 20.49921  -14.44611 -9.35801  1.000 43.19908  ?  171  PHE A N   1 
ATOM   1302 C  CA  . PHE A 1 171 ? 19.18091  -14.79416 -9.85946  1.000 43.89736  ?  171  PHE A CA  1 
ATOM   1303 C  C   . PHE A 1 171 ? 18.51828  -15.85616 -9.00641  1.000 45.93175  ?  171  PHE A C   1 
ATOM   1304 O  O   . PHE A 1 171 ? 17.28667  -15.87237 -8.93156  1.000 48.99618  ?  171  PHE A O   1 
ATOM   1305 C  CB  . PHE A 1 171 ? 19.25827  -15.20275 -11.33521 1.000 43.29710  ?  171  PHE A CB  1 
ATOM   1306 C  CG  . PHE A 1 171 ? 19.23139  -14.02460 -12.26454 1.000 42.79866  ?  171  PHE A CG  1 
ATOM   1307 C  CD1 . PHE A 1 171 ? 18.16342  -13.15148 -12.24422 1.000 45.94255  ?  171  PHE A CD1 1 
ATOM   1308 C  CD2 . PHE A 1 171 ? 20.28833  -13.75973 -13.11274 1.000 47.16415  ?  171  PHE A CD2 1 
ATOM   1309 C  CE1 . PHE A 1 171 ? 18.13343  -12.04265 -13.08051 1.000 49.20135  ?  171  PHE A CE1 1 
ATOM   1310 C  CE2 . PHE A 1 171 ? 20.26268  -12.66247 -13.94971 1.000 49.06254  ?  171  PHE A CE2 1 
ATOM   1311 C  CZ  . PHE A 1 171 ? 19.18067  -11.79820 -13.92604 1.000 51.53497  ?  171  PHE A CZ  1 
ATOM   1312 N  N   . ALA A 1 172 ? 19.30319  -16.69185 -8.31214  1.000 45.16751  ?  172  ALA A N   1 
ATOM   1313 C  CA  . ALA A 1 172 ? 18.73225  -17.57224 -7.29560  1.000 43.84481  ?  172  ALA A CA  1 
ATOM   1314 C  C   . ALA A 1 172 ? 18.00204  -16.77628 -6.21838  1.000 46.93989  ?  172  ALA A C   1 
ATOM   1315 O  O   . ALA A 1 172 ? 16.93211  -17.18401 -5.75281  1.000 48.58068  ?  172  ALA A O   1 
ATOM   1316 C  CB  . ALA A 1 172 ? 19.82333  -18.43299 -6.66404  1.000 47.38904  ?  172  ALA A CB  1 
ATOM   1317 N  N   . PHE A 1 173 ? 18.55957  -15.64071 -5.79733  1.000 47.16094  ?  173  PHE A N   1 
ATOM   1318 C  CA  . PHE A 1 173 ? 17.80040  -14.85372 -4.82010  1.000 45.93008  ?  173  PHE A CA  1 
ATOM   1319 C  C   . PHE A 1 173 ? 16.71728  -13.98589 -5.47770  1.000 46.03103  ?  173  PHE A C   1 
ATOM   1320 O  O   . PHE A 1 173 ? 15.60554  -13.86283 -4.94382  1.000 44.95435  ?  173  PHE A O   1 
ATOM   1321 C  CB  . PHE A 1 173 ? 18.72933  -13.96192 -3.99032  1.000 40.94744  ?  173  PHE A CB  1 
ATOM   1322 C  CG  . PHE A 1 173 ? 17.99965  -13.14023 -2.95751  1.000 43.74541  ?  173  PHE A CG  1 
ATOM   1323 C  CD1 . PHE A 1 173 ? 18.02561  -11.74410 -3.01310  1.000 42.75829  ?  173  PHE A CD1 1 
ATOM   1324 C  CD2 . PHE A 1 173 ? 17.29345  -13.76023 -1.93088  1.000 39.31701  ?  173  PHE A CD2 1 
ATOM   1325 C  CE1 . PHE A 1 173 ? 17.34442  -10.97918 -2.06860  1.000 41.58751  ?  173  PHE A CE1 1 
ATOM   1326 C  CE2 . PHE A 1 173 ? 16.60880  -13.01196 -0.97779  1.000 39.53804  ?  173  PHE A CE2 1 
ATOM   1327 C  CZ  . PHE A 1 173 ? 16.63939  -11.61520 -1.04348  1.000 47.24672  ?  173  PHE A CZ  1 
ATOM   1328 N  N   . TRP A 1 174 ? 17.03041  -13.34477 -6.60744  1.000 39.57808  ?  174  TRP A N   1 
ATOM   1329 C  CA  . TRP A 1 174 ? 16.09667  -12.44257 -7.28308  1.000 43.68647  ?  174  TRP A CA  1 
ATOM   1330 C  C   . TRP A 1 174 ? 15.51978  -13.15913 -8.50229  1.000 42.90218  ?  174  TRP A C   1 
ATOM   1331 O  O   . TRP A 1 174 ? 15.95962  -12.96386 -9.63940  1.000 41.57611  ?  174  TRP A O   1 
ATOM   1332 C  CB  . TRP A 1 174 ? 16.79401  -11.14535 -7.69834  1.000 41.80156  ?  174  TRP A CB  1 
ATOM   1333 C  CG  . TRP A 1 174 ? 17.36704  -10.29305 -6.60156  1.000 46.05337  ?  174  TRP A CG  1 
ATOM   1334 C  CD1 . TRP A 1 174 ? 18.67915  -10.21206 -6.22224  1.000 41.89723  ?  174  TRP A CD1 1 
ATOM   1335 C  CD2 . TRP A 1 174 ? 16.65392  -9.34770  -5.78753  1.000 43.44548  ?  174  TRP A CD2 1 
ATOM   1336 N  NE1 . TRP A 1 174 ? 18.82655  -9.27152  -5.21800  1.000 40.51701  ?  174  TRP A NE1 1 
ATOM   1337 C  CE2 . TRP A 1 174 ? 17.59751  -8.73642  -4.92836  1.000 41.29893  ?  174  TRP A CE2 1 
ATOM   1338 C  CE3 . TRP A 1 174 ? 15.31007  -8.95893  -5.70358  1.000 43.14574  ?  174  TRP A CE3 1 
ATOM   1339 C  CZ2 . TRP A 1 174 ? 17.23465  -7.76942  -3.98914  1.000 43.09645  ?  174  TRP A CZ2 1 
ATOM   1340 C  CZ3 . TRP A 1 174 ? 14.95126  -7.98169  -4.76997  1.000 41.97031  ?  174  TRP A CZ3 1 
ATOM   1341 C  CH2 . TRP A 1 174 ? 15.90839  -7.40384  -3.92883  1.000 40.01529  ?  174  TRP A CH2 1 
ATOM   1342 N  N   . GLU A 1 175 ? 14.49037  -13.97640 -8.26458  1.000 44.93172  ?  175  GLU A N   1 
ATOM   1343 C  CA  . GLU A 1 175 ? 13.93898  -14.78756 -9.35386  1.000 51.41970  ?  175  GLU A CA  1 
ATOM   1344 C  C   . GLU A 1 175 ? 13.45903  -13.92702 -10.51848 1.000 45.74862  ?  175  GLU A C   1 
ATOM   1345 O  O   . GLU A 1 175 ? 13.47247  -14.38148 -11.66379 1.000 45.98527  ?  175  GLU A O   1 
ATOM   1346 C  CB  . GLU A 1 175 ? 12.79302  -15.66984 -8.84480  1.000 51.84896  ?  175  GLU A CB  1 
ATOM   1347 C  CG  . GLU A 1 175 ? 13.19898  -16.77833 -7.82773  1.000 63.44314  ?  175  GLU A CG  1 
ATOM   1348 C  CD  . GLU A 1 175 ? 14.12640  -17.88258 -8.37703  1.000 71.53896  ?  175  GLU A CD  1 
ATOM   1349 O  OE1 . GLU A 1 175 ? 15.16283  -17.58388 -9.02882  1.000 69.57165  ?  175  GLU A OE1 1 
ATOM   1350 O  OE2 . GLU A 1 175 ? 13.81969  -19.07193 -8.12275  1.000 80.92748  -1 175  GLU A OE2 1 
ATOM   1351 N  N   . ASP A 1 176 ? 13.07673  -12.67798 -10.26172 1.000 45.65329  ?  176  ASP A N   1 
ATOM   1352 C  CA  . ASP A 1 176 ? 12.54646  -11.79372 -11.29133 1.000 33.16833  ?  176  ASP A CA  1 
ATOM   1353 C  C   . ASP A 1 176 ? 13.46827  -10.61629 -11.55932 1.000 47.10744  ?  176  ASP A C   1 
ATOM   1354 O  O   . ASP A 1 176 ? 13.02919  -9.59875  -12.10597 1.000 42.79958  ?  176  ASP A O   1 
ATOM   1355 C  CB  . ASP A 1 176 ? 11.16262  -11.29472 -10.88511 1.000 40.97824  ?  176  ASP A CB  1 
ATOM   1356 C  CG  . ASP A 1 176 ? 10.07147  -12.32133 -11.15095 1.000 57.57026  ?  176  ASP A CG  1 
ATOM   1357 O  OD1 . ASP A 1 176 ? 10.37546  -13.35534 -11.80084 1.000 58.24243  -1 176  ASP A OD1 1 
ATOM   1358 O  OD2 . ASP A 1 176 ? 8.91511   -12.10885 -10.69790 1.000 63.94927  -1 176  ASP A OD2 1 
ATOM   1359 N  N   . GLY A 1 177 ? 14.73365  -10.71688 -11.16281 1.000 43.31085  ?  177  GLY A N   1 
ATOM   1360 C  CA  . GLY A 1 177 ? 15.61145  -9.57480  -11.18963 1.000 41.11049  ?  177  GLY A CA  1 
ATOM   1361 C  C   . GLY A 1 177 ? 15.41114  -8.71952  -9.95315  1.000 46.57365  ?  177  GLY A C   1 
ATOM   1362 O  O   . GLY A 1 177 ? 14.47475  -8.89276  -9.16580  1.000 40.89217  ?  177  GLY A O   1 
ATOM   1363 N  N   . ALA A 1 178 ? 16.32958  -7.78416  -9.77190  1.000 40.73715  ?  178  ALA A N   1 
ATOM   1364 C  CA  . ALA A 1 178 ? 16.32098  -6.96903  -8.57282  1.000 45.08278  ?  178  ALA A CA  1 
ATOM   1365 C  C   . ALA A 1 178 ? 15.25033  -5.88887  -8.67174  1.000 43.50300  ?  178  ALA A C   1 
ATOM   1366 O  O   . ALA A 1 178 ? 15.07624  -5.25636  -9.72361  1.000 42.99839  ?  178  ALA A O   1 
ATOM   1367 C  CB  . ALA A 1 178 ? 17.69602  -6.33761  -8.36127  1.000 41.49551  ?  178  ALA A CB  1 
ATOM   1368 N  N   . LYS A 1 179 ? 14.52091  -5.68709  -7.57629  1.000 40.01946  ?  179  LYS A N   1 
ATOM   1369 C  CA  . LYS A 1 179 ? 13.60829  -4.55731  -7.47282  1.000 37.41089  ?  179  LYS A CA  1 
ATOM   1370 C  C   . LYS A 1 179 ? 14.39043  -3.36319  -6.92586  1.000 34.44807  ?  179  LYS A C   1 
ATOM   1371 O  O   . LYS A 1 179 ? 14.99418  -3.44893  -5.85803  1.000 35.27777  ?  179  LYS A O   1 
ATOM   1372 C  CB  . LYS A 1 179 ? 12.42463  -4.91730  -6.57970  1.000 40.70536  ?  179  LYS A CB  1 
ATOM   1373 C  CG  . LYS A 1 179 ? 11.74167  -6.25878  -6.93312  1.000 44.61274  ?  179  LYS A CG  1 
ATOM   1374 C  CD  . LYS A 1 179 ? 11.02568  -6.21394  -8.29287  1.000 49.31782  ?  179  LYS A CD  1 
ATOM   1375 C  CE  . LYS A 1 179 ? 10.76230  -7.62155  -8.85557  1.000 52.48379  ?  179  LYS A CE  1 
ATOM   1376 N  NZ  . LYS A 1 179 ? 9.55609   -8.30170  -8.27891  1.000 50.98545  ?  179  LYS A NZ  1 
ATOM   1377 N  N   . LEU A 1 180 ? 14.40555  -2.25802  -7.66607  1.000 39.52148  ?  180  LEU A N   1 
ATOM   1378 C  CA  . LEU A 1 180 ? 15.21793  -1.11635  -7.24946  1.000 34.73439  ?  180  LEU A CA  1 
ATOM   1379 C  C   . LEU A 1 180 ? 14.80374  -0.58290  -5.89267  1.000 33.86242  ?  180  LEU A C   1 
ATOM   1380 O  O   . LEU A 1 180 ? 15.59657  0.11567   -5.25095  1.000 32.35188  ?  180  LEU A O   1 
ATOM   1381 C  CB  . LEU A 1 180 ? 15.13441  0.01954   -8.27565  1.000 30.96755  ?  180  LEU A CB  1 
ATOM   1382 C  CG  . LEU A 1 180 ? 15.72738  -0.23651  -9.66005  1.000 35.77963  ?  180  LEU A CG  1 
ATOM   1383 C  CD1 . LEU A 1 180 ? 15.46425  0.91129   -10.60400 1.000 40.38778  ?  180  LEU A CD1 1 
ATOM   1384 C  CD2 . LEU A 1 180 ? 17.22522  -0.51016  -9.53620  1.000 37.76018  ?  180  LEU A CD2 1 
ATOM   1385 N  N   . GLU A 1 181 ? 13.57091  -0.84386  -5.46333  1.000 29.68193  ?  181  GLU A N   1 
ATOM   1386 C  CA  . GLU A 1 181 ? 13.14282  -0.33954  -4.17323  1.000 34.94748  ?  181  GLU A CA  1 
ATOM   1387 C  C   . GLU A 1 181 ? 13.38355  -1.32141  -3.03896  1.000 36.14207  ?  181  GLU A C   1 
ATOM   1388 O  O   . GLU A 1 181 ? 13.25766  -0.91857  -1.88453  1.000 34.67667  ?  181  GLU A O   1 
ATOM   1389 C  CB  . GLU A 1 181 ? 11.66402  0.07883   -4.18697  1.000 37.05019  ?  181  GLU A CB  1 
ATOM   1390 C  CG  . GLU A 1 181 ? 10.65474  -0.89618  -4.77686  1.000 45.50945  ?  181  GLU A CG  1 
ATOM   1391 C  CD  . GLU A 1 181 ? 10.75288  -1.02265  -6.30317  1.000 49.10058  ?  181  GLU A CD  1 
ATOM   1392 O  OE1 . GLU A 1 181 ? 11.71492  -1.65853  -6.80142  1.000 51.50960  ?  181  GLU A OE1 1 
ATOM   1393 O  OE2 . GLU A 1 181 ? 9.90578   -0.44829  -7.01316  1.000 53.73625  -1 181  GLU A OE2 1 
ATOM   1394 N  N   . GLU A 1 182 ? 13.75484  -2.57560  -3.33442  1.000 33.43593  ?  182  GLU A N   1 
ATOM   1395 C  CA  . GLU A 1 182 ? 14.02920  -3.58761  -2.32234  1.000 31.20628  ?  182  GLU A CA  1 
ATOM   1396 C  C   . GLU A 1 182 ? 15.51150  -3.89448  -2.19062  1.000 34.20300  ?  182  GLU A C   1 
ATOM   1397 O  O   . GLU A 1 182 ? 15.90054  -4.66633  -1.29991  1.000 32.48013  ?  182  GLU A O   1 
ATOM   1398 C  CB  . GLU A 1 182 ? 13.27992  -4.90086  -2.64023  1.000 31.83765  ?  182  GLU A CB  1 
ATOM   1399 C  CG  . GLU A 1 182 ? 11.78525  -4.79514  -2.74812  1.000 32.48735  ?  182  GLU A CG  1 
ATOM   1400 C  CD  . GLU A 1 182 ? 11.13174  -6.13872  -3.07678  1.000 42.63512  ?  182  GLU A CD  1 
ATOM   1401 O  OE1 . GLU A 1 182 ? 11.85266  -7.12366  -3.35350  1.000 40.07065  ?  182  GLU A OE1 1 
ATOM   1402 O  OE2 . GLU A 1 182 ? 9.89165   -6.22660  -3.03481  1.000 43.95634  -1 182  GLU A OE2 1 
ATOM   1403 N  N   . LEU A 1 183 ? 16.33890  -3.30765  -3.05781  1.000 35.24848  ?  183  LEU A N   1 
ATOM   1404 C  CA  . LEU A 1 183 ? 17.75281  -3.64412  -3.14363  1.000 31.77802  ?  183  LEU A CA  1 
ATOM   1405 C  C   . LEU A 1 183 ? 18.49652  -3.27144  -1.87230  1.000 31.04103  ?  183  LEU A C   1 
ATOM   1406 O  O   . LEU A 1 183 ? 19.44447  -3.96196  -1.47048  1.000 30.83900  ?  183  LEU A O   1 
ATOM   1407 C  CB  . LEU A 1 183 ? 18.35832  -2.91833  -4.34459  1.000 34.02120  ?  183  LEU A CB  1 
ATOM   1408 C  CG  . LEU A 1 183 ? 19.71086  -3.40813  -4.83817  1.000 36.06622  ?  183  LEU A CG  1 
ATOM   1409 C  CD1 . LEU A 1 183 ? 19.71543  -4.91362  -4.99654  1.000 31.83920  ?  183  LEU A CD1 1 
ATOM   1410 C  CD2 . LEU A 1 183 ? 19.97631  -2.72306  -6.15348  1.000 39.39595  ?  183  LEU A CD2 1 
ATOM   1411 N  N   . HIS A 1 184 ? 18.10677  -2.16237  -1.24428  1.000 29.28149  ?  184  HIS A N   1 
ATOM   1412 C  CA  . HIS A 1 184 ? 18.82147  -1.72386  -0.05147  1.000 29.57104  ?  184  HIS A CA  1 
ATOM   1413 C  C   . HIS A 1 184 ? 18.69388  -2.71900  1.10186   1.000 25.04102  ?  184  HIS A C   1 
ATOM   1414 O  O   . HIS A 1 184 ? 19.63219  -2.87829  1.88168   1.000 26.18113  ?  184  HIS A O   1 
ATOM   1415 C  CB  . HIS A 1 184 ? 18.32755  -0.34235  0.36583   1.000 22.45918  ?  184  HIS A CB  1 
ATOM   1416 C  CG  . HIS A 1 184 ? 16.93856  -0.32719  0.92738   1.000 23.36319  ?  184  HIS A CG  1 
ATOM   1417 N  ND1 . HIS A 1 184 ? 16.68913  -0.25032  2.28096   1.000 23.40194  ?  184  HIS A ND1 1 
ATOM   1418 C  CD2 . HIS A 1 184 ? 15.72679  -0.31227  0.32042   1.000 28.48086  ?  184  HIS A CD2 1 
ATOM   1419 C  CE1 . HIS A 1 184 ? 15.38294  -0.21405  2.48746   1.000 26.64382  ?  184  HIS A CE1 1 
ATOM   1420 N  NE2 . HIS A 1 184 ? 14.77399  -0.26682  1.31382   1.000 31.36064  ?  184  HIS A NE2 1 
ATOM   1421 N  N   . ILE A 1 185 ? 17.55028  -3.38707  1.23289   1.000 24.48842  ?  185  ILE A N   1 
ATOM   1422 C  CA  . ILE A 1 185 ? 17.39008  -4.37283  2.30956   1.000 27.08861  ?  185  ILE A CA  1 
ATOM   1423 C  C   . ILE A 1 185 ? 18.39317  -5.52495  2.15014   1.000 25.44567  ?  185  ILE A C   1 
ATOM   1424 O  O   . ILE A 1 185 ? 19.03093  -5.97106  3.12253   1.000 25.08291  ?  185  ILE A O   1 
ATOM   1425 C  CB  . ILE A 1 185 ? 15.93086  -4.86452  2.32655   1.000 28.02836  ?  185  ILE A CB  1 
ATOM   1426 C  CG1 . ILE A 1 185 ? 15.02252  -3.64836  2.61247   1.000 25.81655  ?  185  ILE A CG1 1 
ATOM   1427 C  CG2 . ILE A 1 185 ? 15.74846  -6.05562  3.31596   1.000 24.08553  ?  185  ILE A CG2 1 
ATOM   1428 C  CD1 . ILE A 1 185 ? 13.50257  -3.92176  2.52505   1.000 22.29972  ?  185  ILE A CD1 1 
ATOM   1429 N  N   . TRP A 1 186 ? 18.56991  -5.99009  0.91503   1.000 24.50162  ?  186  TRP A N   1 
ATOM   1430 C  CA  . TRP A 1 186 ? 19.51616  -7.06024  0.61921   1.000 31.28655  ?  186  TRP A CA  1 
ATOM   1431 C  C   . TRP A 1 186 ? 20.95145  -6.60199  0.84512   1.000 28.84718  ?  186  TRP A C   1 
ATOM   1432 O  O   . TRP A 1 186 ? 21.77332  -7.34317  1.40325   1.000 27.71330  ?  186  TRP A O   1 
ATOM   1433 C  CB  . TRP A 1 186 ? 19.31459  -7.52299  -0.82676  1.000 31.58528  ?  186  TRP A CB  1 
ATOM   1434 C  CG  . TRP A 1 186 ? 20.09461  -8.76591  -1.23622  1.000 29.84700  ?  186  TRP A CG  1 
ATOM   1435 C  CD1 . TRP A 1 186 ? 20.08214  -9.96541  -0.62167  1.000 29.77646  ?  186  TRP A CD1 1 
ATOM   1436 C  CD2 . TRP A 1 186 ? 20.96473  -8.90450  -2.37568  1.000 32.78982  ?  186  TRP A CD2 1 
ATOM   1437 N  NE1 . TRP A 1 186 ? 20.89979  -10.85166 -1.28138  1.000 32.33367  ?  186  TRP A NE1 1 
ATOM   1438 C  CE2 . TRP A 1 186 ? 21.44265  -10.23491 -2.37410  1.000 32.17361  ?  186  TRP A CE2 1 
ATOM   1439 C  CE3 . TRP A 1 186 ? 21.39402  -8.03301  -3.38678  1.000 27.98938  ?  186  TRP A CE3 1 
ATOM   1440 C  CZ2 . TRP A 1 186 ? 22.32472  -10.72658 -3.35680  1.000 26.32585  ?  186  TRP A CZ2 1 
ATOM   1441 C  CZ3 . TRP A 1 186 ? 22.27873  -8.51070  -4.35747  1.000 29.26182  ?  186  TRP A CZ3 1 
ATOM   1442 C  CH2 . TRP A 1 186 ? 22.74163  -9.85554  -4.32143  1.000 36.05116  ?  186  TRP A CH2 1 
ATOM   1443 N  N   . MET A 1 187 ? 21.27245  -5.37510  0.42900   1.000 29.38374  ?  187  MET A N   1 
ATOM   1444 C  CA  . MET A 1 187 ? 22.64801  -4.94502  0.60427   1.000 25.02460  ?  187  MET A CA  1 
ATOM   1445 C  C   . MET A 1 187 ? 22.95219  -4.73166  2.08136   1.000 23.17687  ?  187  MET A C   1 
ATOM   1446 O  O   . MET A 1 187 ? 24.05635  -5.02538  2.54302   1.000 25.42494  ?  187  MET A O   1 
ATOM   1447 C  CB  . MET A 1 187 ? 22.92124  -3.69441  -0.23477  1.000 27.32948  ?  187  MET A CB  1 
ATOM   1448 C  CG  . MET A 1 187 ? 22.71455  -3.91707  -1.73194  1.000 25.29100  ?  187  MET A CG  1 
ATOM   1449 S  SD  . MET A 1 187 ? 22.85296  -2.39343  -2.70471  1.000 34.29272  ?  187  MET A SD  1 
ATOM   1450 C  CE  . MET A 1 187 ? 24.38251  -1.66458  -2.12268  1.000 24.12342  ?  187  MET A CE  1 
ATOM   1451 N  N   . ARG A 1 188 ? 21.97679  -4.25924  2.84888   1.000 24.47555  ?  188  ARG A N   1 
ATOM   1452 C  CA  . ARG A 1 188 ? 22.20117  -4.09327  4.27314   1.000 26.05468  ?  188  ARG A CA  1 
ATOM   1453 C  C   . ARG A 1 188 ? 22.35219  -5.44008  4.96839   1.000 26.54554  ?  188  ARG A C   1 
ATOM   1454 O  O   . ARG A 1 188 ? 23.12528  -5.56812  5.92225   1.000 25.74110  ?  188  ARG A O   1 
ATOM   1455 C  CB  . ARG A 1 188 ? 21.05576  -3.30024  4.89551   1.000 23.77098  ?  188  ARG A CB  1 
ATOM   1456 C  CG  . ARG A 1 188 ? 21.46758  -2.60808  6.16574   1.000 23.13666  ?  188  ARG A CG  1 
ATOM   1457 C  CD  . ARG A 1 188 ? 20.30411  -1.78964  6.74543   1.000 26.48300  ?  188  ARG A CD  1 
ATOM   1458 N  NE  . ARG A 1 188 ? 20.04646  -0.56740  6.00264   1.000 24.45851  ?  188  ARG A NE  1 
ATOM   1459 C  CZ  . ARG A 1 188 ? 19.16679  -0.42562  5.02152   1.000 26.07877  ?  188  ARG A CZ  1 
ATOM   1460 N  NH1 . ARG A 1 188 ? 18.40642  -1.43916  4.60045   1.000 20.82725  ?  188  ARG A NH1 1 
ATOM   1461 N  NH2 . ARG A 1 188 ? 19.04894  0.76486   4.44078   1.000 25.04813  ?  188  ARG A NH2 1 
ATOM   1462 N  N   . PHE A 1 189 ? 21.60833  -6.44310  4.51471   1.000 26.77677  ?  189  PHE A N   1 
ATOM   1463 C  CA  . PHE A 1 189 ? 21.72763  -7.77762  5.09222   1.000 27.08820  ?  189  PHE A CA  1 
ATOM   1464 C  C   . PHE A 1 189 ? 23.11836  -8.36238  4.82131   1.000 27.21521  ?  189  PHE A C   1 
ATOM   1465 O  O   . PHE A 1 189 ? 23.78808  -8.87148  5.73584   1.000 28.84683  ?  189  PHE A O   1 
ATOM   1466 C  CB  . PHE A 1 189 ? 20.59364  -8.66891  4.52853   1.000 22.66662  ?  189  PHE A CB  1 
ATOM   1467 C  CG  . PHE A 1 189 ? 20.77724  -10.13371 4.81839   1.000 31.66982  ?  189  PHE A CG  1 
ATOM   1468 C  CD1 . PHE A 1 189 ? 20.32401  -10.68509 6.01612   1.000 23.90271  ?  189  PHE A CD1 1 
ATOM   1469 C  CD2 . PHE A 1 189 ? 21.43699  -10.95321 3.90110   1.000 26.26667  ?  189  PHE A CD2 1 
ATOM   1470 C  CE1 . PHE A 1 189 ? 20.52086  -12.03326 6.28301   1.000 31.16016  ?  189  PHE A CE1 1 
ATOM   1471 C  CE2 . PHE A 1 189 ? 21.62967  -12.30321 4.16032   1.000 29.81537  ?  189  PHE A CE2 1 
ATOM   1472 C  CZ  . PHE A 1 189 ? 21.17580  -12.83993 5.35878   1.000 32.78102  ?  189  PHE A CZ  1 
ATOM   1473 N  N   . LEU A 1 190 ? 23.58398  -8.28099  3.56973   1.000 27.65479  ?  190  LEU A N   1 
ATOM   1474 C  CA  . LEU A 1 190 ? 24.92702  -8.77764  3.26531   1.000 25.56223  ?  190  LEU A CA  1 
ATOM   1475 C  C   . LEU A 1 190 ? 25.98326  -7.98310  4.02672   1.000 28.92421  ?  190  LEU A C   1 
ATOM   1476 O  O   . LEU A 1 190 ? 26.98183  -8.55332  4.49535   1.000 27.20946  ?  190  LEU A O   1 
ATOM   1477 C  CB  . LEU A 1 190 ? 25.19813  -8.72646  1.75494   1.000 27.71679  ?  190  LEU A CB  1 
ATOM   1478 C  CG  . LEU A 1 190 ? 24.18047  -9.42995  0.84300   1.000 27.74604  ?  190  LEU A CG  1 
ATOM   1479 C  CD1 . LEU A 1 190 ? 24.27031  -8.92038  -0.59698  1.000 17.08125  ?  190  LEU A CD1 1 
ATOM   1480 C  CD2 . LEU A 1 190 ? 24.35197  -10.97229 0.89063   1.000 25.54890  ?  190  LEU A CD2 1 
ATOM   1481 N  N   . PHE A 1 191 ? 25.78572  -6.66116  4.15707   1.000 27.70789  ?  191  PHE A N   1 
ATOM   1482 C  CA  . PHE A 1 191 ? 26.70357  -5.84353  4.95032   1.000 25.34043  ?  191  PHE A CA  1 
ATOM   1483 C  C   . PHE A 1 191 ? 26.75607  -6.33899  6.38994   1.000 25.13523  ?  191  PHE A C   1 
ATOM   1484 O  O   . PHE A 1 191 ? 27.83425  -6.40402  6.99804   1.000 29.43904  ?  191  PHE A O   1 
ATOM   1485 C  CB  . PHE A 1 191 ? 26.25926  -4.38535  4.87853   1.000 27.92518  ?  191  PHE A CB  1 
ATOM   1486 C  CG  . PHE A 1 191 ? 27.15390  -3.41483  5.60191   1.000 26.85012  ?  191  PHE A CG  1 
ATOM   1487 C  CD1 . PHE A 1 191 ? 28.46218  -3.21622  5.20788   1.000 25.42363  ?  191  PHE A CD1 1 
ATOM   1488 C  CD2 . PHE A 1 191 ? 26.65035  -2.64769  6.63184   1.000 24.92408  ?  191  PHE A CD2 1 
ATOM   1489 C  CE1 . PHE A 1 191 ? 29.27206  -2.28496  5.86643   1.000 28.08983  ?  191  PHE A CE1 1 
ATOM   1490 C  CE2 . PHE A 1 191 ? 27.45083  -1.71113  7.29229   1.000 23.46417  ?  191  PHE A CE2 1 
ATOM   1491 C  CZ  . PHE A 1 191 ? 28.76085  -1.54159  6.91277   1.000 26.00592  ?  191  PHE A CZ  1 
ATOM   1492 N  N   . SER A 1 192 ? 25.59850  -6.71112  6.93990   1.000 26.38692  ?  192  SER A N   1 
ATOM   1493 C  CA  . SER A 1 192 ? 25.54422  -7.29561  8.27826   1.000 28.55001  ?  192  SER A CA  1 
ATOM   1494 C  C   . SER A 1 192 ? 26.35512  -8.59021  8.34464   1.000 28.49845  ?  192  SER A C   1 
ATOM   1495 O  O   . SER A 1 192 ? 27.09638  -8.81426  9.30384   1.000 28.96784  ?  192  SER A O   1 
ATOM   1496 C  CB  . SER A 1 192 ? 24.07528  -7.55219  8.66022   1.000 27.79040  ?  192  SER A CB  1 
ATOM   1497 O  OG  . SER A 1 192 ? 23.89487  -8.16851  9.94139   1.000 28.17176  ?  192  SER A OG  1 
ATOM   1498 N  N   . CYS A 1 193 ? 26.21264  -9.45665  7.33951   1.000 24.70946  ?  193  CYS A N   1 
ATOM   1499 C  CA  . CYS A 1 193 ? 26.98168  -10.70528 7.33467   1.000 30.85761  ?  193  CYS A CA  1 
ATOM   1500 C  C   . CYS A 1 193 ? 28.47446  -10.41830 7.33328   1.000 35.69273  ?  193  CYS A C   1 
ATOM   1501 O  O   . CYS A 1 193 ? 29.24524  -11.02651 8.09985   1.000 31.20696  ?  193  CYS A O   1 
ATOM   1502 C  CB  . CYS A 1 193 ? 26.62162  -11.55378 6.11806   1.000 25.94994  ?  193  CYS A CB  1 
ATOM   1503 S  SG  . CYS A 1 193 ? 24.91085  -12.14898 6.15074   1.000 31.09640  ?  193  CYS A SG  1 
ATOM   1504 N  N   . LEU A 1 194 ? 28.88933  -9.45708  6.49634   1.000 30.10778  ?  194  LEU A N   1 
ATOM   1505 C  CA  . LEU A 1 194 ? 30.28888  -9.08414  6.43096   1.000 30.14854  ?  194  LEU A CA  1 
ATOM   1506 C  C   . LEU A 1 194 ? 30.78252  -8.60249  7.78629   1.000 31.35130  ?  194  LEU A C   1 
ATOM   1507 O  O   . LEU A 1 194 ? 31.78670  -9.10193  8.30575   1.000 29.52806  ?  194  LEU A O   1 
ATOM   1508 C  CB  . LEU A 1 194 ? 30.47243  -7.99932  5.37547   1.000 31.30268  ?  194  LEU A CB  1 
ATOM   1509 C  CG  . LEU A 1 194 ? 31.82468  -7.32277  5.43222   1.000 30.39226  ?  194  LEU A CG  1 
ATOM   1510 C  CD1 . LEU A 1 194 ? 32.91385  -8.39765  5.19808   1.000 27.15852  ?  194  LEU A CD1 1 
ATOM   1511 C  CD2 . LEU A 1 194 ? 31.90785  -6.20893  4.37075   1.000 25.35643  ?  194  LEU A CD2 1 
ATOM   1512 N  N   . VAL A 1 195 ? 30.07578  -7.62753  8.37036   1.000 31.57700  ?  195  VAL A N   1 
ATOM   1513 C  CA  . VAL A 1 195 ? 30.51151  -7.00079  9.61986   1.000 30.20795  ?  195  VAL A CA  1 
ATOM   1514 C  C   . VAL A 1 195 ? 30.52713  -8.02413  10.75876  1.000 30.06629  ?  195  VAL A C   1 
ATOM   1515 O  O   . VAL A 1 195 ? 31.49791  -8.11700  11.51755  1.000 30.32122  ?  195  VAL A O   1 
ATOM   1516 C  CB  . VAL A 1 195 ? 29.60104  -5.79895  9.94820   1.000 30.63154  ?  195  VAL A CB  1 
ATOM   1517 C  CG1 . VAL A 1 195 ? 29.77059  -5.35841  11.38062  1.000 29.77407  ?  195  VAL A CG1 1 
ATOM   1518 C  CG2 . VAL A 1 195 ? 29.83422  -4.61176  8.96084   1.000 27.48705  ?  195  VAL A CG2 1 
ATOM   1519 N  N   . ASP A 1 196 ? 29.45141  -8.80923  10.91374  1.000 30.66164  ?  196  ASP A N   1 
ATOM   1520 C  CA  . ASP A 1 196 ? 29.44962  -9.73218  12.04482  1.000 30.09882  ?  196  ASP A CA  1 
ATOM   1521 C  C   . ASP A 1 196 ? 30.59466  -10.73272 11.91060  1.000 25.23978  ?  196  ASP A C   1 
ATOM   1522 O  O   . ASP A 1 196 ? 31.30036  -10.99160 12.88439  1.000 25.06928  ?  196  ASP A O   1 
ATOM   1523 C  CB  . ASP A 1 196 ? 28.09902  -10.43796 12.19585  1.000 30.91065  ?  196  ASP A CB  1 
ATOM   1524 C  CG  . ASP A 1 196 ? 27.89068  -11.04916 13.60997  1.000 31.86355  ?  196  ASP A CG  1 
ATOM   1525 O  OD1 . ASP A 1 196 ? 28.50395  -10.55439 14.57986  1.000 26.97570  ?  196  ASP A OD1 1 
ATOM   1526 O  OD2 . ASP A 1 196 ? 27.09596  -12.02128 13.75307  1.000 31.40716  -1 196  ASP A OD2 1 
ATOM   1527 N  N   . ALA A 1 197 ? 30.84950  -11.23077 10.70008  1.000 28.38546  ?  197  ALA A N   1 
ATOM   1528 C  CA  . ALA A 1 197 ? 31.91316  -12.22118 10.51639  1.000 31.34126  ?  197  ALA A CA  1 
ATOM   1529 C  C   . ALA A 1 197 ? 33.29053  -11.60563 10.75471  1.000 29.32575  ?  197  ALA A C   1 
ATOM   1530 O  O   . ALA A 1 197 ? 34.14966  -12.21816 11.40194  1.000 27.03892  ?  197  ALA A O   1 
ATOM   1531 C  CB  . ALA A 1 197 ? 31.82465  -12.82032 9.10625   1.000 26.30454  ?  197  ALA A CB  1 
ATOM   1532 N  N   . ASP A 1 198 ? 33.50714  -10.38710 10.24867  1.000 27.55646  ?  198  ASP A N   1 
ATOM   1533 C  CA  . ASP A 1 198 ? 34.75860  -9.66236  10.46872  1.000 23.34317  ?  198  ASP A CA  1 
ATOM   1534 C  C   . ASP A 1 198 ? 35.02072  -9.49951  11.95690  1.000 29.04916  ?  198  ASP A C   1 
ATOM   1535 O  O   . ASP A 1 198 ? 36.07164  -9.90423  12.47080  1.000 29.51011  ?  198  ASP A O   1 
ATOM   1536 C  CB  . ASP A 1 198 ? 34.64070  -8.30302  9.76555   1.000 29.25186  ?  198  ASP A CB  1 
ATOM   1537 C  CG  . ASP A 1 198 ? 35.93938  -7.51158  9.69706   1.000 28.70956  ?  198  ASP A CG  1 
ATOM   1538 O  OD1 . ASP A 1 198 ? 37.06722  -8.07111  9.70839   1.000 30.64332  ?  198  ASP A OD1 1 
ATOM   1539 O  OD2 . ASP A 1 198 ? 35.82743  -6.27034  9.57290   1.000 36.12292  -1 198  ASP A OD2 1 
ATOM   1540 N  N   . PHE A 1 199 ? 34.04134  -8.94151  12.67394  1.000 31.91116  ?  199  PHE A N   1 
ATOM   1541 C  CA  . PHE A 1 199 ? 34.18988  -8.69815  14.10670  1.000 33.88473  ?  199  PHE A CA  1 
ATOM   1542 C  C   . PHE A 1 199 ? 34.39249  -9.99834  14.87035  1.000 28.44702  ?  199  PHE A C   1 
ATOM   1543 O  O   . PHE A 1 199 ? 35.21954  -10.06517 15.78021  1.000 32.50150  ?  199  PHE A O   1 
ATOM   1544 C  CB  . PHE A 1 199 ? 32.96070  -7.95430  14.66089  1.000 30.16721  ?  199  PHE A CB  1 
ATOM   1545 C  CG  . PHE A 1 199 ? 32.86411  -6.51034  14.20902  1.000 35.74595  ?  199  PHE A CG  1 
ATOM   1546 C  CD1 . PHE A 1 199 ? 33.74057  -6.00366  13.24686  1.000 37.01497  ?  199  PHE A CD1 1 
ATOM   1547 C  CD2 . PHE A 1 199 ? 31.90351  -5.67367  14.73999  1.000 29.82174  ?  199  PHE A CD2 1 
ATOM   1548 C  CE1 . PHE A 1 199 ? 33.66715  -4.68338  12.82590  1.000 35.16069  ?  199  PHE A CE1 1 
ATOM   1549 C  CE2 . PHE A 1 199 ? 31.81873  -4.35265  14.33874  1.000 36.78856  ?  199  PHE A CE2 1 
ATOM   1550 C  CZ  . PHE A 1 199 ? 32.71657  -3.85043  13.37311  1.000 36.21790  ?  199  PHE A CZ  1 
ATOM   1551 N  N   . LEU A 1 200 ? 33.62957  -11.03587 14.54196  1.000 29.99386  ?  200  LEU A N   1 
ATOM   1552 C  CA  . LEU A 1 200 ? 33.76781  -12.28118 15.28445  1.000 28.47348  ?  200  LEU A CA  1 
ATOM   1553 C  C   . LEU A 1 200 ? 35.14970  -12.88915 15.08681  1.000 31.34132  ?  200  LEU A C   1 
ATOM   1554 O  O   . LEU A 1 200 ? 35.77630  -13.34737 16.05547  1.000 32.02343  ?  200  LEU A O   1 
ATOM   1555 C  CB  . LEU A 1 200 ? 32.65605  -13.25560 14.89176  1.000 25.97374  ?  200  LEU A CB  1 
ATOM   1556 C  CG  . LEU A 1 200 ? 31.31228  -12.85278 15.49000  1.000 29.77097  ?  200  LEU A CG  1 
ATOM   1557 C  CD1 . LEU A 1 200 ? 30.17966  -13.63478 14.82415  1.000 28.69573  ?  200  LEU A CD1 1 
ATOM   1558 C  CD2 . LEU A 1 200 ? 31.30703  -12.98010 17.04765  1.000 24.16781  ?  200  LEU A CD2 1 
ATOM   1559 N  N   . ASP A 1 201 ? 35.65989  -12.88238 13.85031  1.000 31.67256  ?  201  ASP A N   1 
ATOM   1560 C  CA  . ASP A 1 201 ? 37.01036  -13.39889 13.61603  1.000 31.75153  ?  201  ASP A CA  1 
ATOM   1561 C  C   . ASP A 1 201 ? 38.04852  -12.59720 14.38875  1.000 33.40590  ?  201  ASP A C   1 
ATOM   1562 O  O   . ASP A 1 201 ? 38.96770  -13.16142 15.01819  1.000 31.04631  ?  201  ASP A O   1 
ATOM   1563 C  CB  . ASP A 1 201 ? 37.33693  -13.37285 12.12002  1.000 32.88840  ?  201  ASP A CB  1 
ATOM   1564 C  CG  . ASP A 1 201 ? 38.58550  -14.17627 11.78057  1.000 30.98208  ?  201  ASP A CG  1 
ATOM   1565 O  OD1 . ASP A 1 201 ? 38.53936  -15.41389 11.94840  1.000 39.17740  ?  201  ASP A OD1 1 
ATOM   1566 O  OD2 . ASP A 1 201 ? 39.60494  -13.58283 11.36426  1.000 33.17558  -1 201  ASP A OD2 1 
ATOM   1567 N  N   . THR A 1 202 ? 37.92627  -11.26652 14.34869  1.000 29.54913  ?  202  THR A N   1 
ATOM   1568 C  CA  . THR A 1 202 ? 38.89110  -10.45337 15.07929  1.000 31.52892  ?  202  THR A CA  1 
ATOM   1569 C  C   . THR A 1 202 ? 38.79703  -10.71474 16.57593  1.000 30.62110  ?  202  THR A C   1 
ATOM   1570 O  O   . THR A 1 202 ? 39.81395  -10.71779 17.28392  1.000 30.75163  ?  202  THR A O   1 
ATOM   1571 C  CB  . THR A 1 202 ? 38.66953  -8.97078  14.77955  1.000 29.06377  ?  202  THR A CB  1 
ATOM   1572 O  OG1 . THR A 1 202 ? 38.59415  -8.80350  13.36519  1.000 33.17132  ?  202  THR A OG1 1 
ATOM   1573 C  CG2 . THR A 1 202 ? 39.83041  -8.14379  15.31106  1.000 24.92733  ?  202  THR A CG2 1 
ATOM   1574 N  N   . GLU A 1 203 ? 37.58169  -10.89611 17.08715  1.000 29.75724  ?  203  GLU A N   1 
ATOM   1575 C  CA  . GLU A 1 203 ? 37.45624  -11.12613 18.52254  1.000 34.13716  ?  203  GLU A CA  1 
ATOM   1576 C  C   . GLU A 1 203 ? 38.08146  -12.47276 18.90215  1.000 34.44125  ?  203  GLU A C   1 
ATOM   1577 O  O   . GLU A 1 203 ? 38.73105  -12.59566 19.94883  1.000 31.31752  ?  203  GLU A O   1 
ATOM   1578 C  CB  . GLU A 1 203 ? 35.98949  -11.02294 18.91946  1.000 36.14175  ?  203  GLU A CB  1 
ATOM   1579 C  CG  . GLU A 1 203 ? 35.68272  -11.42437 20.34871  1.000 50.54875  ?  203  GLU A CG  1 
ATOM   1580 C  CD  . GLU A 1 203 ? 34.18468  -11.43089 20.64268  1.000 56.02681  ?  203  GLU A CD  1 
ATOM   1581 O  OE1 . GLU A 1 203 ? 33.55288  -12.50212 20.46041  1.000 58.07476  ?  203  GLU A OE1 1 
ATOM   1582 O  OE2 . GLU A 1 203 ? 33.64316  -10.39228 21.09119  1.000 57.53195  -1 203  GLU A OE2 1 
ATOM   1583 N  N   . ALA A 1 204 ? 37.94743  -13.47370 18.02103  1.000 33.74427  ?  204  ALA A N   1 
ATOM   1584 C  CA  . ALA A 1 204 ? 38.69818  -14.71527 18.18751  1.000 34.69445  ?  204  ALA A CA  1 
ATOM   1585 C  C   . ALA A 1 204 ? 40.17471  -14.40607 18.38001  1.000 37.46633  ?  204  ALA A C   1 
ATOM   1586 O  O   . ALA A 1 204 ? 40.77896  -14.80584 19.38295  1.000 37.31849  ?  204  ALA A O   1 
ATOM   1587 C  CB  . ALA A 1 204 ? 38.49862  -15.62715 16.97721  1.000 28.92079  ?  204  ALA A CB  1 
ATOM   1588 N  N   . PHE A 1 205 ? 40.73716  -13.60025 17.47290  1.000 31.21014  ?  205  PHE A N   1 
ATOM   1589 C  CA  . PHE A 1 205 ? 42.15418  -13.25750 17.57011  1.000 34.66734  ?  205  PHE A CA  1 
ATOM   1590 C  C   . PHE A 1 205 ? 42.46622  -12.58473 18.89961  1.000 35.07970  ?  205  PHE A C   1 
ATOM   1591 O  O   . PHE A 1 205 ? 43.46290  -12.91414 19.55463  1.000 34.28100  ?  205  PHE A O   1 
ATOM   1592 C  CB  . PHE A 1 205 ? 42.56153  -12.35260 16.39206  1.000 31.23635  ?  205  PHE A CB  1 
ATOM   1593 C  CG  . PHE A 1 205 ? 43.73719  -11.45436 16.67680  1.000 32.79179  ?  205  PHE A CG  1 
ATOM   1594 C  CD1 . PHE A 1 205 ? 45.02948  -11.97295 16.73138  1.000 30.50690  ?  205  PHE A CD1 1 
ATOM   1595 C  CD2 . PHE A 1 205 ? 43.55499  -10.07394 16.86084  1.000 32.53977  ?  205  PHE A CD2 1 
ATOM   1596 C  CE1 . PHE A 1 205 ? 46.11438  -11.15454 16.98144  1.000 30.38234  ?  205  PHE A CE1 1 
ATOM   1597 C  CE2 . PHE A 1 205 ? 44.63906  -9.24411  17.10250  1.000 29.41531  ?  205  PHE A CE2 1 
ATOM   1598 C  CZ  . PHE A 1 205 ? 45.91843  -9.78420  17.16973  1.000 33.32062  ?  205  PHE A CZ  1 
ATOM   1599 N  N   . MET A 1 206 ? 41.60111  -11.66248 19.32424  1.000 32.90724  ?  206  MET A N   1 
ATOM   1600 C  CA  . MET A 1 206 ? 41.81678  -10.93002 20.56395  1.000 32.24655  ?  206  MET A CA  1 
ATOM   1601 C  C   . MET A 1 206 ? 41.88720  -11.86656 21.76119  1.000 35.22913  ?  206  MET A C   1 
ATOM   1602 O  O   . MET A 1 206 ? 42.53635  -11.54429 22.76078  1.000 37.11783  ?  206  MET A O   1 
ATOM   1603 C  CB  . MET A 1 206 ? 40.70114  -9.90441  20.78687  1.000 32.64201  ?  206  MET A CB  1 
ATOM   1604 C  CG  . MET A 1 206 ? 40.66471  -8.80632  19.75468  1.000 37.29739  ?  206  MET A CG  1 
ATOM   1605 S  SD  . MET A 1 206 ? 42.03740  -7.63092  19.91423  1.000 40.65068  ?  206  MET A SD  1 
ATOM   1606 C  CE  . MET A 1 206 ? 42.07241  -7.00312  18.20571  1.000 42.60563  ?  206  MET A CE  1 
ATOM   1607 N  N   . ASN A 1 207 ? 41.20061  -13.00329 21.70628  1.000 35.10131  ?  207  ASN A N   1 
ATOM   1608 C  CA  . ASN A 1 207 ? 41.24723  -13.93945 22.82225  1.000 31.60825  ?  207  ASN A CA  1 
ATOM   1609 C  C   . ASN A 1 207 ? 42.27076  -15.04975 22.61235  1.000 35.30149  ?  207  ASN A C   1 
ATOM   1610 O  O   . ASN A 1 207 ? 42.33528  -15.98248 23.41617  1.000 35.25331  ?  207  ASN A O   1 
ATOM   1611 C  CB  . ASN A 1 207 ? 39.86516  -14.52906 23.06694  1.000 31.18920  ?  207  ASN A CB  1 
ATOM   1612 C  CG  . ASN A 1 207 ? 38.92120  -13.52455 23.66595  1.000 39.29802  ?  207  ASN A CG  1 
ATOM   1613 O  OD1 . ASN A 1 207 ? 39.18880  -12.96457 24.73271  1.000 32.91336  ?  207  ASN A OD1 1 
ATOM   1614 N  ND2 . ASN A 1 207 ? 37.81920  -13.25655 22.96786  1.000 41.41283  ?  207  ASN A ND2 1 
ATOM   1615 N  N   . GLY A 1 208 ? 43.06306  -14.97561 21.54627  1.000 33.47588  ?  208  GLY A N   1 
ATOM   1616 C  CA  . GLY A 1 208 ? 44.07235  -15.97002 21.28421  1.000 36.65087  ?  208  GLY A CA  1 
ATOM   1617 C  C   . GLY A 1 208 ? 43.59843  -17.16229 20.48789  1.000 38.75778  ?  208  GLY A C   1 
ATOM   1618 O  O   . GLY A 1 208 ? 44.39811  -18.05578 20.22069  1.000 35.61789  ?  208  GLY A O   1 
ATOM   1619 N  N   . TYR A 1 209 ? 42.33907  -17.19192 20.06717  1.000 37.98708  ?  209  TYR A N   1 
ATOM   1620 C  CA  . TYR A 1 209 ? 41.82953  -18.32831 19.31175  1.000 37.43464  ?  209  TYR A CA  1 
ATOM   1621 C  C   . TYR A 1 209 ? 42.03401  -18.13214 17.81025  1.000 36.96603  ?  209  TYR A C   1 
ATOM   1622 O  O   . TYR A 1 209 ? 42.06354  -17.00670 17.31396  1.000 34.00015  ?  209  TYR A O   1 
ATOM   1623 C  CB  . TYR A 1 209 ? 40.35465  -18.55640 19.65217  1.000 32.73193  ?  209  TYR A CB  1 
ATOM   1624 C  CG  . TYR A 1 209 ? 40.20882  -19.11303 21.05275  1.000 39.53610  ?  209  TYR A CG  1 
ATOM   1625 C  CD1 . TYR A 1 209 ? 40.60662  -20.41434 21.33601  1.000 35.86102  ?  209  TYR A CD1 1 
ATOM   1626 C  CD2 . TYR A 1 209 ? 39.70156  -18.34030 22.09290  1.000 36.92876  ?  209  TYR A CD2 1 
ATOM   1627 C  CE1 . TYR A 1 209 ? 40.49552  -20.94129 22.60519  1.000 39.31940  ?  209  TYR A CE1 1 
ATOM   1628 C  CE2 . TYR A 1 209 ? 39.57653  -18.86681 23.37798  1.000 40.69740  ?  209  TYR A CE2 1 
ATOM   1629 C  CZ  . TYR A 1 209 ? 39.99048  -20.17166 23.62293  1.000 43.47721  ?  209  TYR A CZ  1 
ATOM   1630 O  OH  . TYR A 1 209 ? 39.88690  -20.72358 24.87513  1.000 49.51691  ?  209  TYR A OH  1 
ATOM   1631 N  N   . ALA A 1 210 ? 42.17456  -19.25197 17.08910  1.000 35.54376  ?  210  ALA A N   1 
ATOM   1632 C  CA  . ALA A 1 210 ? 42.51153  -19.20414 15.65983  1.000 37.99723  ?  210  ALA A CA  1 
ATOM   1633 C  C   . ALA A 1 210 ? 41.40299  -18.57769 14.81030  1.000 36.27661  ?  210  ALA A C   1 
ATOM   1634 O  O   . ALA A 1 210 ? 41.68636  -17.90285 13.81336  1.000 41.01310  ?  210  ALA A O   1 
ATOM   1635 C  CB  . ALA A 1 210 ? 42.81416  -20.61154 15.13766  1.000 40.62041  ?  210  ALA A CB  1 
ATOM   1636 N  N   . ASP A 1 211 ? 40.14437  -18.81227 15.15721  1.000 36.10700  ?  211  ASP A N   1 
ATOM   1637 C  CA  . ASP A 1 211 ? 39.02651  -18.33619 14.35206  1.000 31.08532  ?  211  ASP A CA  1 
ATOM   1638 C  C   . ASP A 1 211 ? 37.77334  -18.35123 15.22530  1.000 32.89581  ?  211  ASP A C   1 
ATOM   1639 O  O   . ASP A 1 211 ? 37.81097  -18.80393 16.36955  1.000 31.98972  ?  211  ASP A O   1 
ATOM   1640 C  CB  . ASP A 1 211 ? 38.87371  -19.19432 13.09618  1.000 40.14795  ?  211  ASP A CB  1 
ATOM   1641 C  CG  . ASP A 1 211 ? 38.71460  -20.67025 13.41730  1.000 40.59623  ?  211  ASP A CG  1 
ATOM   1642 O  OD1 . ASP A 1 211 ? 38.05363  -20.99961 14.42751  1.000 40.85927  -1 211  ASP A OD1 1 
ATOM   1643 O  OD2 . ASP A 1 211 ? 39.24152  -21.50854 12.65707  1.000 50.16774  -1 211  ASP A OD2 1 
ATOM   1644 N  N   . ALA A 1 212 ? 36.64848  -17.86697 14.66911  1.000 28.86984  ?  212  ALA A N   1 
ATOM   1645 C  CA  . ALA A 1 212 ? 35.42444  -17.71979 15.46250  1.000 32.46522  ?  212  ALA A CA  1 
ATOM   1646 C  C   . ALA A 1 212 ? 34.84894  -19.06676 15.88296  1.000 34.84611  ?  212  ALA A C   1 
ATOM   1647 O  O   . ALA A 1 212 ? 34.33513  -19.20398 16.99968  1.000 34.63701  ?  212  ALA A O   1 
ATOM   1648 C  CB  . ALA A 1 212 ? 34.35966  -16.93517 14.68544  1.000 33.20344  ?  212  ALA A CB  1 
ATOM   1649 N  N   . ASP A 1 213 ? 34.87288  -20.06051 14.99058  1.000 38.15706  ?  213  ASP A N   1 
ATOM   1650 C  CA  . ASP A 1 213 ? 34.36706  -21.37398 15.38682  1.000 39.44177  ?  213  ASP A CA  1 
ATOM   1651 C  C   . ASP A 1 213 ? 35.18378  -21.93425 16.54266  1.000 38.51517  ?  213  ASP A C   1 
ATOM   1652 O  O   . ASP A 1 213 ? 34.61982  -22.47731 17.50156  1.000 42.72668  ?  213  ASP A O   1 
ATOM   1653 C  CB  . ASP A 1 213 ? 34.37286  -22.33053 14.20482  1.000 42.22364  ?  213  ASP A CB  1 
ATOM   1654 C  CG  . ASP A 1 213 ? 33.20968  -22.10018 13.28192  1.000 46.30895  ?  213  ASP A CG  1 
ATOM   1655 O  OD1 . ASP A 1 213 ? 32.13256  -21.72073 13.77305  1.000 46.49897  ?  213  ASP A OD1 1 
ATOM   1656 O  OD2 . ASP A 1 213 ? 33.37176  -22.29465 12.06253  1.000 51.73404  -1 213  ASP A OD2 1 
ATOM   1657 N  N   . THR A 1 214 ? 36.50976  -21.76479 16.48701  1.000 36.22383  ?  214  THR A N   1 
ATOM   1658 C  CA  . THR A 1 214 ? 37.38034  -22.25081 17.55542  1.000 37.82714  ?  214  THR A CA  1 
ATOM   1659 C  C   . THR A 1 214 ? 37.01886  -21.60600 18.88575  1.000 38.65368  ?  214  THR A C   1 
ATOM   1660 O  O   . THR A 1 214 ? 36.85915  -22.29297 19.90416  1.000 39.63031  ?  214  THR A O   1 
ATOM   1661 C  CB  . THR A 1 214 ? 38.85122  -21.97409 17.19577  1.000 38.25390  ?  214  THR A CB  1 
ATOM   1662 O  OG1 . THR A 1 214 ? 39.15204  -22.55153 15.92134  1.000 37.82901  ?  214  THR A OG1 1 
ATOM   1663 C  CG2 . THR A 1 214 ? 39.79501  -22.54546 18.24898  1.000 36.39212  ?  214  THR A CG2 1 
ATOM   1664 N  N   . ALA A 1 215 ? 36.87614  -20.27499 18.89616  1.000 35.35708  ?  215  ALA A N   1 
ATOM   1665 C  CA  . ALA A 1 215 ? 36.49752  -19.60256 20.13194  1.000 38.95713  ?  215  ALA A CA  1 
ATOM   1666 C  C   . ALA A 1 215 ? 35.12453  -20.05760 20.60831  1.000 36.15548  ?  215  ALA A C   1 
ATOM   1667 O  O   . ALA A 1 215 ? 34.89205  -20.18145 21.81429  1.000 44.45419  ?  215  ALA A O   1 
ATOM   1668 C  CB  . ALA A 1 215 ? 36.53465  -18.08509 19.94611  1.000 36.54391  ?  215  ALA A CB  1 
ATOM   1669 N  N   . GLN A 1 216 ? 34.20073  -20.30683 19.67965  1.000 41.05114  ?  216  GLN A N   1 
ATOM   1670 C  CA  . GLN A 1 216 ? 32.87967  -20.79240 20.06960  1.000 46.52095  ?  216  GLN A CA  1 
ATOM   1671 C  C   . GLN A 1 216 ? 32.98595  -22.13407 20.77876  1.000 46.25200  ?  216  GLN A C   1 
ATOM   1672 O  O   . GLN A 1 216 ? 32.43754  -22.31180 21.86919  1.000 50.11974  ?  216  GLN A O   1 
ATOM   1673 C  CB  . GLN A 1 216 ? 31.96283  -20.90789 18.84784  1.000 52.40512  ?  216  GLN A CB  1 
ATOM   1674 C  CG  . GLN A 1 216 ? 30.50057  -21.26726 19.19259  1.000 53.66645  ?  216  GLN A CG  1 
ATOM   1675 C  CD  . GLN A 1 216 ? 29.85885  -20.26599 20.17129  1.000 62.66180  ?  216  GLN A CD  1 
ATOM   1676 O  OE1 . GLN A 1 216 ? 29.60987  -20.57734 21.34851  1.000 60.05939  ?  216  GLN A OE1 1 
ATOM   1677 N  NE2 . GLN A 1 216 ? 29.59269  -19.05903 19.68007  1.000 61.53041  ?  216  GLN A NE2 1 
ATOM   1678 N  N   . ALA A 1 217 ? 33.73698  -23.07113 20.19392  1.000 46.15026  ?  217  ALA A N   1 
ATOM   1679 C  CA  . ALA A 1 217 ? 33.91230  -24.39717 20.79428  1.000 49.89322  ?  217  ALA A CA  1 
ATOM   1680 C  C   . ALA A 1 217 ? 34.68780  -24.34551 22.11188  1.000 53.83266  ?  217  ALA A C   1 
ATOM   1681 O  O   . ALA A 1 217 ? 34.53708  -25.24107 22.95193  1.000 60.76387  ?  217  ALA A O   1 
ATOM   1682 C  CB  . ALA A 1 217 ? 34.60475  -25.33407 19.80254  1.000 46.73881  ?  217  ALA A CB  1 
ATOM   1683 N  N   . ALA A 1 218 ? 35.51460  -23.31701 22.32062  1.000 55.48852  ?  218  ALA A N   1 
ATOM   1684 C  CA  . ALA A 1 218 ? 36.20249  -23.19226 23.60389  1.000 56.27947  ?  218  ALA A CA  1 
ATOM   1685 C  C   . ALA A 1 218 ? 35.26747  -22.74771 24.72953  1.000 59.37799  ?  218  ALA A C   1 
ATOM   1686 O  O   . ALA A 1 218 ? 35.54439  -23.01684 25.90527  1.000 64.03785  ?  218  ALA A O   1 
ATOM   1687 C  CB  . ALA A 1 218 ? 37.36654  -22.21449 23.48191  1.000 51.56528  ?  218  ALA A CB  1 
ATOM   1688 N  N   . GLY A 1 219 ? 34.18724  -22.04234 24.40917  1.000 59.44631  ?  219  GLY A N   1 
ATOM   1689 C  CA  . GLY A 1 219 ? 33.29888  -21.52448 25.43556  1.000 55.73416  ?  219  GLY A CA  1 
ATOM   1690 C  C   . GLY A 1 219 ? 33.69888  -20.14108 25.92347  1.000 63.79966  ?  219  GLY A C   1 
ATOM   1691 O  O   . GLY A 1 219 ? 33.86987  -19.21140 25.12666  1.000 64.69291  ?  219  GLY A O   1 
ATOM   1692 N  N   . PHE A 1 224 ? 24.05451  -21.11619 25.07558  1.000 68.42833  ?  224  PHE A N   1 
ATOM   1693 C  CA  . PHE A 1 224 ? 22.64630  -20.91146 24.73588  1.000 65.35075  ?  224  PHE A CA  1 
ATOM   1694 C  C   . PHE A 1 224 ? 21.93535  -22.23796 24.45571  1.000 60.94236  ?  224  PHE A C   1 
ATOM   1695 O  O   . PHE A 1 224 ? 22.29958  -22.96219 23.51927  1.000 56.56433  ?  224  PHE A O   1 
ATOM   1696 C  CB  . PHE A 1 224 ? 22.51435  -19.98484 23.51632  1.000 63.68839  ?  224  PHE A CB  1 
ATOM   1697 C  CG  . PHE A 1 224 ? 22.84759  -18.54600 23.80833  1.000 62.36627  ?  224  PHE A CG  1 
ATOM   1698 C  CD1 . PHE A 1 224 ? 22.32251  -17.91415 24.93440  1.000 59.82008  ?  224  PHE A CD1 1 
ATOM   1699 C  CD2 . PHE A 1 224 ? 23.67854  -17.82658 22.95947  1.000 55.72292  ?  224  PHE A CD2 1 
ATOM   1700 C  CE1 . PHE A 1 224 ? 22.61979  -16.58900 25.21397  1.000 60.32604  ?  224  PHE A CE1 1 
ATOM   1701 C  CE2 . PHE A 1 224 ? 23.98932  -16.50697 23.23065  1.000 58.33017  ?  224  PHE A CE2 1 
ATOM   1702 C  CZ  . PHE A 1 224 ? 23.45775  -15.88135 24.36477  1.000 61.71851  ?  224  PHE A CZ  1 
ATOM   1703 N  N   . PRO A 1 225 ? 20.92406  -22.55502 25.26351  1.000 59.92688  ?  225  PRO A N   1 
ATOM   1704 C  CA  . PRO A 1 225 ? 20.10531  -23.73633 24.97868  1.000 56.17404  ?  225  PRO A CA  1 
ATOM   1705 C  C   . PRO A 1 225 ? 19.36382  -23.55526 23.66662  1.000 57.68262  ?  225  PRO A C   1 
ATOM   1706 O  O   . PRO A 1 225 ? 19.06547  -22.43475 23.24921  1.000 61.35091  ?  225  PRO A O   1 
ATOM   1707 C  CB  . PRO A 1 225 ? 19.13663  -23.80017 26.16459  1.000 56.38282  ?  225  PRO A CB  1 
ATOM   1708 C  CG  . PRO A 1 225 ? 19.65420  -22.81386 27.16609  1.000 52.31706  ?  225  PRO A CG  1 
ATOM   1709 C  CD  . PRO A 1 225 ? 20.42265  -21.79791 26.41769  1.000 57.63522  ?  225  PRO A CD  1 
ATOM   1710 N  N   . GLY A 1 226 ? 19.09507  -24.67215 23.00040  1.000 57.57452  ?  226  GLY A N   1 
ATOM   1711 C  CA  . GLY A 1 226 ? 18.32097  -24.63031 21.78002  1.000 55.01273  ?  226  GLY A CA  1 
ATOM   1712 C  C   . GLY A 1 226 ? 16.84315  -24.42560 22.05229  1.000 52.89138  ?  226  GLY A C   1 
ATOM   1713 O  O   . GLY A 1 226 ? 16.33779  -24.65177 23.15392  1.000 51.55767  ?  226  GLY A O   1 
ATOM   1714 N  N   . LEU A 1 227 ? 16.12630  -24.00204 21.01081  1.000 52.44236  ?  227  LEU A N   1 
ATOM   1715 C  CA  . LEU A 1 227 ? 14.71477  -23.68875 21.17878  1.000 46.19411  ?  227  LEU A CA  1 
ATOM   1716 C  C   . LEU A 1 227 ? 13.91137  -24.88807 21.66412  1.000 47.59200  ?  227  LEU A C   1 
ATOM   1717 O  O   . LEU A 1 227 ? 12.83741  -24.69922 22.24984  1.000 41.14789  ?  227  LEU A O   1 
ATOM   1718 C  CB  . LEU A 1 227 ? 14.14754  -23.15381 19.86677  1.000 36.42086  ?  227  LEU A CB  1 
ATOM   1719 C  CG  . LEU A 1 227 ? 14.64955  -21.74242 19.49393  1.000 45.75529  ?  227  LEU A CG  1 
ATOM   1720 C  CD1 . LEU A 1 227 ? 13.96501  -21.23092 18.23207  1.000 35.79252  ?  227  LEU A CD1 1 
ATOM   1721 C  CD2 . LEU A 1 227 ? 14.45726  -20.76978 20.65980  1.000 41.11801  ?  227  LEU A CD2 1 
ATOM   1722 N  N   . ASP A 1 228 ? 14.40532  -26.11340 21.44197  1.000 47.53562  ?  228  ASP A N   1 
ATOM   1723 C  CA  . ASP A 1 228 ? 13.72359  -27.29834 21.96194  1.000 45.06109  ?  228  ASP A CA  1 
ATOM   1724 C  C   . ASP A 1 228 ? 13.73538  -27.30569 23.47847  1.000 44.24862  ?  228  ASP A C   1 
ATOM   1725 O  O   . ASP A 1 228 ? 12.70671  -27.53276 24.12813  1.000 50.36808  ?  228  ASP A O   1 
ATOM   1726 C  CB  . ASP A 1 228 ? 14.38952  -28.57050 21.43384  1.000 55.15974  ?  228  ASP A CB  1 
ATOM   1727 C  CG  . ASP A 1 228 ? 13.74635  -29.06908 20.15929  1.000 61.59058  ?  228  ASP A CG  1 
ATOM   1728 O  OD1 . ASP A 1 228 ? 12.67820  -29.73308 20.24325  1.000 67.14966  -1 228  ASP A OD1 1 
ATOM   1729 O  OD2 . ASP A 1 228 ? 14.30912  -28.79086 19.07250  1.000 66.13509  -1 228  ASP A OD2 1 
ATOM   1730 N  N   . GLU A 1 229 ? 14.90683  -27.07900 24.06101  1.000 46.70606  ?  229  GLU A N   1 
ATOM   1731 C  CA  . GLU A 1 229 ? 15.00183  -27.02180 25.51046  1.000 48.62047  ?  229  GLU A CA  1 
ATOM   1732 C  C   . GLU A 1 229 ? 14.17009  -25.86806 26.05678  1.000 47.16803  ?  229  GLU A C   1 
ATOM   1733 O  O   . GLU A 1 229 ? 13.46455  -26.02285 27.06087  1.000 48.20019  ?  229  GLU A O   1 
ATOM   1734 C  CB  . GLU A 1 229 ? 16.47583  -26.90698 25.91830  1.000 48.50280  ?  229  GLU A CB  1 
ATOM   1735 C  CG  . GLU A 1 229 ? 16.73795  -26.42136 27.33964  1.000 51.21795  ?  229  GLU A CG  1 
ATOM   1736 C  CD  . GLU A 1 229 ? 16.24390  -27.39409 28.40509  1.000 56.67160  ?  229  GLU A CD  1 
ATOM   1737 O  OE1 . GLU A 1 229 ? 15.76608  -28.49829 28.03597  1.000 58.69935  ?  229  GLU A OE1 1 
ATOM   1738 O  OE2 . GLU A 1 229 ? 16.33937  -27.05574 29.61340  1.000 53.13804  -1 229  GLU A OE2 1 
ATOM   1739 N  N   . LEU A 1 230 ? 14.22491  -24.71011 25.39116  1.000 46.10569  ?  230  LEU A N   1 
ATOM   1740 C  CA  . LEU A 1 230 ? 13.43073  -23.56052 25.81533  1.000 45.12407  ?  230  LEU A CA  1 
ATOM   1741 C  C   . LEU A 1 230 ? 11.95028  -23.88193 25.78813  1.000 45.07992  ?  230  LEU A C   1 
ATOM   1742 O  O   . LEU A 1 230 ? 11.20861  -23.50252 26.69740  1.000 43.17269  ?  230  LEU A O   1 
ATOM   1743 C  CB  . LEU A 1 230 ? 13.71393  -22.35714 24.91444  1.000 46.38851  ?  230  LEU A CB  1 
ATOM   1744 C  CG  . LEU A 1 230 ? 15.08710  -21.70821 25.04406  1.000 53.31721  ?  230  LEU A CG  1 
ATOM   1745 C  CD1 . LEU A 1 230 ? 15.01691  -20.22296 24.68854  1.000 46.28005  ?  230  LEU A CD1 1 
ATOM   1746 C  CD2 . LEU A 1 230 ? 15.58997  -21.90655 26.45832  1.000 50.86374  ?  230  LEU A CD2 1 
ATOM   1747 N  N   . HIS A 1 231 ? 11.50106  -24.56718 24.73651  1.000 42.25066  ?  231  HIS A N   1 
ATOM   1748 C  CA  . HIS A 1 231 ? 10.11157  -24.97158 24.65112  1.000 42.61745  ?  231  HIS A CA  1 
ATOM   1749 C  C   . HIS A 1 231 ? 9.74203   -25.90381 25.79546  1.000 49.03046  ?  231  HIS A C   1 
ATOM   1750 O  O   . HIS A 1 231 ? 8.67791   -25.75199 26.40673  1.000 49.27512  ?  231  HIS A O   1 
ATOM   1751 C  CB  . HIS A 1 231 ? 9.86553   -25.63982 23.30657  1.000 46.13572  ?  231  HIS A CB  1 
ATOM   1752 C  CG  . HIS A 1 231 ? 8.51197   -26.26185 23.17282  1.000 45.82943  ?  231  HIS A CG  1 
ATOM   1753 N  ND1 . HIS A 1 231 ? 7.35707   -25.51732 23.07301  1.000 46.77517  ?  231  HIS A ND1 1 
ATOM   1754 C  CD2 . HIS A 1 231 ? 8.13048   -27.55875 23.09769  1.000 47.52269  ?  231  HIS A CD2 1 
ATOM   1755 C  CE1 . HIS A 1 231 ? 6.32158   -26.32724 22.94394  1.000 47.69591  ?  231  HIS A CE1 1 
ATOM   1756 N  NE2 . HIS A 1 231 ? 6.76484   -27.57091 22.95032  1.000 50.94761  ?  231  HIS A NE2 1 
ATOM   1757 N  N   . ARG A 1 232 ? 10.60265  -26.88174 26.09676  1.000 49.06473  ?  232  ARG A N   1 
ATOM   1758 C  CA  . ARG A 1 232 ? 10.30350  -27.79052 27.20435  1.000 49.13299  ?  232  ARG A CA  1 
ATOM   1759 C  C   . ARG A 1 232 ? 10.20442  -27.02827 28.52374  1.000 48.12187  ?  232  ARG A C   1 
ATOM   1760 O  O   . ARG A 1 232 ? 9.29470   -27.26741 29.32844  1.000 49.71567  ?  232  ARG A O   1 
ATOM   1761 C  CB  . ARG A 1 232 ? 11.36702  -28.89361 27.28792  1.000 49.80478  ?  232  ARG A CB  1 
ATOM   1762 C  CG  . ARG A 1 232 ? 11.24881  -29.79785 28.52540  1.000 52.40865  ?  232  ARG A CG  1 
ATOM   1763 C  CD  . ARG A 1 232 ? 12.52999  -30.61226 28.77278  1.000 57.29651  ?  232  ARG A CD  1 
ATOM   1764 N  NE  . ARG A 1 232 ? 13.58770  -29.84423 29.43460  1.000 59.10138  ?  232  ARG A NE  1 
ATOM   1765 C  CZ  . ARG A 1 232 ? 13.46838  -29.19615 30.59140  1.000 58.47696  ?  232  ARG A CZ  1 
ATOM   1766 N  NH1 . ARG A 1 232 ? 12.40665  -29.34478 31.37072  1.000 66.15584  ?  232  ARG A NH1 1 
ATOM   1767 N  NH2 . ARG A 1 232 ? 14.44873  -28.39033 30.98879  1.000 54.75985  ?  232  ARG A NH2 1 
ATOM   1768 N  N   . ARG A 1 233 ? 11.12847  -26.09415 28.75300  1.000 47.72568  ?  233  ARG A N   1 
ATOM   1769 C  CA  . ARG A 1 233 ? 11.05228  -25.24450 29.93682  1.000 49.96670  ?  233  ARG A CA  1 
ATOM   1770 C  C   . ARG A 1 233 ? 9.75372   -24.46280 29.96827  1.000 51.12740  ?  233  ARG A C   1 
ATOM   1771 O  O   . ARG A 1 233 ? 9.11363   -24.34170 31.02151  1.000 51.79854  ?  233  ARG A O   1 
ATOM   1772 C  CB  . ARG A 1 233 ? 12.22022  -24.26377 29.97071  1.000 52.11897  ?  233  ARG A CB  1 
ATOM   1773 C  CG  . ARG A 1 233 ? 13.51926  -24.88124 30.37544  1.000 54.61985  ?  233  ARG A CG  1 
ATOM   1774 C  CD  . ARG A 1 233 ? 14.58440  -23.83980 30.52513  1.000 54.98527  ?  233  ARG A CD  1 
ATOM   1775 N  NE  . ARG A 1 233 ? 15.84642  -24.38500 30.05378  1.000 56.91555  ?  233  ARG A NE  1 
ATOM   1776 C  CZ  . ARG A 1 233 ? 17.02065  -23.79672 30.20724  1.000 59.42257  ?  233  ARG A CZ  1 
ATOM   1777 N  NH1 . ARG A 1 233 ? 17.12991  -22.62816 30.81920  1.000 59.43170  ?  233  ARG A NH1 1 
ATOM   1778 N  NH2 . ARG A 1 233 ? 18.10918  -24.39489 29.72968  1.000 51.25153  ?  233  ARG A NH2 1 
ATOM   1779 N  N   . TYR A 1 234 ? 9.37281   -23.88987 28.82780  1.000 47.14222  ?  234  TYR A N   1 
ATOM   1780 C  CA  . TYR A 1 234 ? 8.14657   -23.11330 28.76616  1.000 45.91712  ?  234  TYR A CA  1 
ATOM   1781 C  C   . TYR A 1 234 ? 6.95322   -23.97956 29.11495  1.000 49.63605  ?  234  TYR A C   1 
ATOM   1782 O  O   . TYR A 1 234 ? 6.04009   -23.53525 29.81704  1.000 50.05158  ?  234  TYR A O   1 
ATOM   1783 C  CB  . TYR A 1 234 ? 7.97641   -22.51588 27.37400  1.000 42.38889  ?  234  TYR A CB  1 
ATOM   1784 C  CG  . TYR A 1 234 ? 6.60300   -21.95133 27.10751  1.000 39.17827  ?  234  TYR A CG  1 
ATOM   1785 C  CD1 . TYR A 1 234 ? 6.29379   -20.65084 27.48971  1.000 38.13635  ?  234  TYR A CD1 1 
ATOM   1786 C  CD2 . TYR A 1 234 ? 5.61831   -22.70181 26.46474  1.000 37.63170  ?  234  TYR A CD2 1 
ATOM   1787 C  CE1 . TYR A 1 234 ? 5.05207   -20.10321 27.25217  1.000 35.04729  ?  234  TYR A CE1 1 
ATOM   1788 C  CE2 . TYR A 1 234 ? 4.35149   -22.15941 26.22377  1.000 38.40989  ?  234  TYR A CE2 1 
ATOM   1789 C  CZ  . TYR A 1 234 ? 4.08820   -20.84315 26.61697  1.000 37.50228  ?  234  TYR A CZ  1 
ATOM   1790 O  OH  . TYR A 1 234 ? 2.86922   -20.24887 26.40121  1.000 37.09973  ?  234  TYR A OH  1 
ATOM   1791 N  N   . GLU A 1 235 ? 6.93394   -25.21409 28.61108  1.000 45.33541  ?  235  GLU A N   1 
ATOM   1792 C  CA  . GLU A 1 235 ? 5.82571   -26.10818 28.92683  1.000 52.14284  ?  235  GLU A CA  1 
ATOM   1793 C  C   . GLU A 1 235 ? 5.78804   -26.41843 30.41847  1.000 59.27386  ?  235  GLU A C   1 
ATOM   1794 O  O   . GLU A 1 235 ? 4.71785   -26.39357 31.03754  1.000 62.23959  ?  235  GLU A O   1 
ATOM   1795 C  CB  . GLU A 1 235 ? 5.92479   -27.38359 28.09276  1.000 46.08862  ?  235  GLU A CB  1 
ATOM   1796 C  CG  . GLU A 1 235 ? 5.38143   -27.16641 26.69890  1.000 51.55334  ?  235  GLU A CG  1 
ATOM   1797 C  CD  . GLU A 1 235 ? 5.51008   -28.36747 25.80659  1.000 56.45206  ?  235  GLU A CD  1 
ATOM   1798 O  OE1 . GLU A 1 235 ? 6.46799   -29.14893 25.99220  1.000 62.65966  ?  235  GLU A OE1 1 
ATOM   1799 O  OE2 . GLU A 1 235 ? 4.65975   -28.51265 24.90122  1.000 59.82314  -1 235  GLU A OE2 1 
ATOM   1800 N  N   . GLN A 1 236 ? 6.95194   -26.67525 31.01949  1.000 53.69017  ?  236  GLN A N   1 
ATOM   1801 C  CA  . GLN A 1 236 ? 7.00084   -26.91398 32.45799  1.000 56.44720  ?  236  GLN A CA  1 
ATOM   1802 C  C   . GLN A 1 236 ? 6.44686   -25.71723 33.22365  1.000 62.20700  ?  236  GLN A C   1 
ATOM   1803 O  O   . GLN A 1 236 ? 5.64748   -25.86542 34.16220  1.000 64.59267  ?  236  GLN A O   1 
ATOM   1804 C  CB  . GLN A 1 236 ? 8.44098   -27.20313 32.86887  1.000 59.33042  ?  236  GLN A CB  1 
ATOM   1805 C  CG  . GLN A 1 236 ? 8.62849   -28.00387 34.14345  1.000 61.50091  ?  236  GLN A CG  1 
ATOM   1806 C  CD  . GLN A 1 236 ? 9.99443   -28.66588 34.17377  1.000 74.50970  ?  236  GLN A CD  1 
ATOM   1807 O  OE1 . GLN A 1 236 ? 10.11323  -29.87051 34.42477  1.000 73.96619  ?  236  GLN A OE1 1 
ATOM   1808 N  NE2 . GLN A 1 236 ? 11.03963  -27.88088 33.88967  1.000 67.21341  ?  236  GLN A NE2 1 
ATOM   1809 N  N   . TYR A 1 237 ? 6.85475   -24.51469 32.81543  1.000 60.85677  ?  237  TYR A N   1 
ATOM   1810 C  CA  . TYR A 1 237 ? 6.42638   -23.29987 33.49301  1.000 56.07692  ?  237  TYR A CA  1 
ATOM   1811 C  C   . TYR A 1 237 ? 4.93127   -23.07040 33.33127  1.000 58.38814  ?  237  TYR A C   1 
ATOM   1812 O  O   . TYR A 1 237 ? 4.24585   -22.71941 34.29556  1.000 62.72269  ?  237  TYR A O   1 
ATOM   1813 C  CB  . TYR A 1 237 ? 7.22172   -22.11467 32.95876  1.000 58.87218  ?  237  TYR A CB  1 
ATOM   1814 C  CG  . TYR A 1 237 ? 6.84328   -20.80153 33.59368  1.000 60.82932  ?  237  TYR A CG  1 
ATOM   1815 C  CD1 . TYR A 1 237 ? 7.30748   -20.46033 34.85809  1.000 58.68229  ?  237  TYR A CD1 1 
ATOM   1816 C  CD2 . TYR A 1 237 ? 6.00467   -19.90666 32.93288  1.000 56.78189  ?  237  TYR A CD2 1 
ATOM   1817 C  CE1 . TYR A 1 237 ? 6.96131   -19.25688 35.44446  1.000 60.21716  ?  237  TYR A CE1 1 
ATOM   1818 C  CE2 . TYR A 1 237 ? 5.64947   -18.70178 33.50761  1.000 56.49094  ?  237  TYR A CE2 1 
ATOM   1819 C  CZ  . TYR A 1 237 ? 6.13121   -18.37832 34.76571  1.000 60.58915  ?  237  TYR A CZ  1 
ATOM   1820 O  OH  . TYR A 1 237 ? 5.77890   -17.17950 35.33868  1.000 51.70423  ?  237  TYR A OH  1 
ATOM   1821 N  N   . MET A 1 238 ? 4.40457   -23.27089 32.12317  1.000 59.20061  ?  238  MET A N   1 
ATOM   1822 C  CA  . MET A 1 238 ? 2.96624   -23.13200 31.90683  1.000 62.10458  ?  238  MET A CA  1 
ATOM   1823 C  C   . MET A 1 238 ? 2.18509   -24.12878 32.75617  1.000 64.49593  ?  238  MET A C   1 
ATOM   1824 O  O   . MET A 1 238 ? 1.15107   -23.78015 33.33904  1.000 62.11690  ?  238  MET A O   1 
ATOM   1825 C  CB  . MET A 1 238 ? 2.62752   -23.32628 30.42587  1.000 53.03972  ?  238  MET A CB  1 
ATOM   1826 C  CG  . MET A 1 238 ? 2.94742   -22.16272 29.48758  1.000 51.00418  ?  238  MET A CG  1 
ATOM   1827 S  SD  . MET A 1 238 ? 3.07879   -20.50244 30.19439  1.000 47.62830  ?  238  MET A SD  1 
ATOM   1828 C  CE  . MET A 1 238 ? 1.34645   -20.07066 30.34988  1.000 47.98925  ?  238  MET A CE  1 
ATOM   1829 N  N   . ALA A 1 239 ? 2.66405   -25.37842 32.82951  1.000 64.16780  ?  239  ALA A N   1 
ATOM   1830 C  CA  . ALA A 1 239 ? 1.95601   -26.41722 33.57379  1.000 64.52961  ?  239  ALA A CA  1 
ATOM   1831 C  C   . ALA A 1 239 ? 1.92896   -26.11065 35.06360  1.000 65.32166  ?  239  ALA A C   1 
ATOM   1832 O  O   . ALA A 1 239 ? 0.90344   -26.30122 35.72705  1.000 72.31506  ?  239  ALA A O   1 
ATOM   1833 C  CB  . ALA A 1 239 ? 2.60090   -27.78089 33.32017  1.000 51.95384  ?  239  ALA A CB  1 
ATOM   1834 N  N   . GLN A 1 240 ? 3.04798   -25.65225 35.61529  1.000 63.10902  ?  240  GLN A N   1 
ATOM   1835 C  CA  . GLN A 1 240 ? 3.03093   -25.30781 37.02847  1.000 67.21995  ?  240  GLN A CA  1 
ATOM   1836 C  C   . GLN A 1 240 ? 2.27946   -24.00346 37.28858  1.000 75.42121  ?  240  GLN A C   1 
ATOM   1837 O  O   . GLN A 1 240 ? 1.78013   -23.80416 38.39790  1.000 77.00972  ?  240  GLN A O   1 
ATOM   1838 C  CB  . GLN A 1 240 ? 4.45511   -25.24127 37.57967  1.000 64.83738  ?  240  GLN A CB  1 
ATOM   1839 C  CG  . GLN A 1 240 ? 5.25932   -24.08839 37.05398  1.000 67.48051  ?  240  GLN A CG  1 
ATOM   1840 C  CD  . GLN A 1 240 ? 6.07330   -23.42003 38.13169  1.000 77.18523  ?  240  GLN A CD  1 
ATOM   1841 O  OE1 . GLN A 1 240 ? 7.09326   -23.95209 38.57396  1.000 86.90358  ?  240  GLN A OE1 1 
ATOM   1842 N  NE2 . GLN A 1 240 ? 5.62806   -22.24439 38.56802  1.000 77.87908  ?  240  GLN A NE2 1 
ATOM   1843 N  N   . LEU A 1 241 ? 2.17908   -23.11057 36.30126  1.000 70.41106  ?  241  LEU A N   1 
ATOM   1844 C  CA  . LEU A 1 241 ? 1.27533   -21.97658 36.45245  1.000 72.67408  ?  241  LEU A CA  1 
ATOM   1845 C  C   . LEU A 1 241 ? -0.16893  -22.45021 36.49765  1.000 74.28333  ?  241  LEU A C   1 
ATOM   1846 O  O   . LEU A 1 241 ? -0.97762  -21.94014 37.28249  1.000 73.73442  ?  241  LEU A O   1 
ATOM   1847 C  CB  . LEU A 1 241 ? 1.47815   -20.98150 35.31083  1.000 67.88507  ?  241  LEU A CB  1 
ATOM   1848 C  CG  . LEU A 1 241 ? 1.12441   -19.52285 35.58743  1.000 75.31114  ?  241  LEU A CG  1 
ATOM   1849 C  CD1 . LEU A 1 241 ? 2.11328   -18.59676 34.88346  1.000 72.80646  ?  241  LEU A CD1 1 
ATOM   1850 C  CD2 . LEU A 1 241 ? -0.31551  -19.20639 35.17335  1.000 74.40053  ?  241  LEU A CD2 1 
ATOM   1851 N  N   . SER A 1 242 ? -0.50263  -23.42857 35.65771  1.000 72.04536  ?  242  SER A N   1 
ATOM   1852 C  CA  . SER A 1 242 ? -1.85074  -23.97745 35.63490  1.000 73.74462  ?  242  SER A CA  1 
ATOM   1853 C  C   . SER A 1 242 ? -2.19389  -24.61941 36.97304  1.000 81.88157  ?  242  SER A C   1 
ATOM   1854 O  O   . SER A 1 242 ? -3.18899  -24.26391 37.61541  1.000 81.31494  ?  242  SER A O   1 
ATOM   1855 C  CB  . SER A 1 242 ? -1.96710  -24.98969 34.49282  1.000 69.39025  ?  242  SER A CB  1 
ATOM   1856 O  OG  . SER A 1 242 ? -3.16522  -25.73862 34.57822  1.000 79.61047  ?  242  SER A OG  1 
ATOM   1857 N  N   . GLU A 1 243 ? -1.34914  -25.54875 37.42491  1.000 83.17911  ?  243  GLU A N   1 
ATOM   1858 C  CA  . GLU A 1 243 ? -1.60116  -26.24226 38.68575  1.000 86.25615  ?  243  GLU A CA  1 
ATOM   1859 C  C   . GLU A 1 243 ? -1.58357  -25.27416 39.86452  1.000 87.75312  ?  243  GLU A C   1 
ATOM   1860 O  O   . GLU A 1 243 ? -2.52789  -25.23371 40.66303  1.000 90.46721  ?  243  GLU A O   1 
ATOM   1861 C  CB  . GLU A 1 243 ? -0.56558  -27.34643 38.88574  1.000 86.01589  ?  243  GLU A CB  1 
ATOM   1862 C  CG  . GLU A 1 243 ? -0.48573  -27.84989 40.30947  1.000 92.26432  ?  243  GLU A CG  1 
ATOM   1863 C  CD  . GLU A 1 243 ? -0.32200  -29.35201 40.37643  1.000 101.52111 ?  243  GLU A CD  1 
ATOM   1864 O  OE1 . GLU A 1 243 ? -1.32788  -30.06471 40.16042  1.000 100.54081 ?  243  GLU A OE1 1 
ATOM   1865 O  OE2 . GLU A 1 243 ? 0.80881   -29.81908 40.64810  1.000 104.69878 -1 243  GLU A OE2 1 
ATOM   1866 N  N   . LYS A 1 244 ? -0.52250  -24.46407 39.96101  1.000 85.94900  ?  244  LYS A N   1 
ATOM   1867 C  CA  . LYS A 1 244 ? -0.29668  -23.57488 41.09884  1.000 86.95590  ?  244  LYS A CA  1 
ATOM   1868 C  C   . LYS A 1 244 ? -1.52004  -22.72870 41.40030  1.000 87.38390  ?  244  LYS A C   1 
ATOM   1869 O  O   . LYS A 1 244 ? -1.99562  -22.68284 42.54018  1.000 92.80232  ?  244  LYS A O   1 
ATOM   1870 C  CB  . LYS A 1 244 ? 0.89861   -22.66814 40.79485  1.000 84.65214  ?  244  LYS A CB  1 
ATOM   1871 C  CG  . LYS A 1 244 ? 1.72309   -22.21594 41.98565  1.000 84.81617  ?  244  LYS A CG  1 
ATOM   1872 C  CD  . LYS A 1 244 ? 2.90361   -21.37260 41.50060  1.000 76.84213  ?  244  LYS A CD  1 
ATOM   1873 C  CE  . LYS A 1 244 ? 3.78548   -20.90275 42.64186  1.000 70.73113  ?  244  LYS A CE  1 
ATOM   1874 N  NZ  . LYS A 1 244 ? 5.00310   -20.21415 42.12475  1.000 64.61271  ?  244  LYS A NZ  1 
ATOM   1875 N  N   . ALA A 1 245 ? -2.04902  -22.05547 40.38625  1.000 88.08397  ?  245  ALA A N   1 
ATOM   1876 C  CA  . ALA A 1 245 ? -3.28108  -21.29014 40.52477  1.000 91.72489  ?  245  ALA A CA  1 
ATOM   1877 C  C   . ALA A 1 245 ? -4.26676  -21.85740 39.52160  1.000 89.05108  ?  245  ALA A C   1 
ATOM   1878 O  O   . ALA A 1 245 ? -4.42926  -21.32220 38.42605  1.000 90.12807  ?  245  ALA A O   1 
ATOM   1879 C  CB  . ALA A 1 245 ? -3.04216  -19.79353 40.30655  1.000 90.02440  ?  245  ALA A CB  1 
ATOM   1880 N  N   . ASP A 1 246 ? -4.93049  -22.94811 39.90430  1.000 90.86333  ?  246  ASP A N   1 
ATOM   1881 C  CA  . ASP A 1 246 ? -6.11328  -23.40353 39.18020  1.000 91.52783  ?  246  ASP A CA  1 
ATOM   1882 C  C   . ASP A 1 246 ? -7.28907  -22.62326 39.74846  1.000 93.12130  ?  246  ASP A C   1 
ATOM   1883 O  O   . ASP A 1 246 ? -8.03971  -23.08740 40.61231  1.000 98.61531  ?  246  ASP A O   1 
ATOM   1884 C  CB  . ASP A 1 246 ? -6.31621  -24.90769 39.30642  1.000 96.50688  ?  246  ASP A CB  1 
ATOM   1885 C  CG  . ASP A 1 246 ? -7.66971  -25.36634 38.75214  1.000 101.82867 ?  246  ASP A CG  1 
ATOM   1886 O  OD1 . ASP A 1 246 ? -8.25041  -24.65528 37.89478  1.000 99.06262  ?  246  ASP A OD1 1 
ATOM   1887 O  OD2 . ASP A 1 246 ? -8.15840  -26.43296 39.19065  1.000 103.82348 -1 246  ASP A OD2 1 
ATOM   1888 N  N   . LYS A 1 247 ? -7.42560  -21.39018 39.27056  1.000 86.47562  ?  247  LYS A N   1 
ATOM   1889 C  CA  . LYS A 1 247 ? -8.59599  -20.61137 39.63785  1.000 91.82464  ?  247  LYS A CA  1 
ATOM   1890 C  C   . LYS A 1 247 ? -9.87285  -21.32563 39.21135  1.000 92.22183  ?  247  LYS A C   1 
ATOM   1891 O  O   . LYS A 1 247 ? -10.87265 -21.31177 39.94139  1.000 92.87195  ?  247  LYS A O   1 
ATOM   1892 C  CB  . LYS A 1 247 ? -8.51038  -19.22066 39.01340  1.000 87.81892  ?  247  LYS A CB  1 
ATOM   1893 N  N   . ASN A 1 248 ? -9.83977  -21.99519 38.05040  1.000 91.07102  ?  248  ASN A N   1 
ATOM   1894 C  CA  . ASN A 1 248 ? -11.04970 -22.45325 37.35755  1.000 88.01716  ?  248  ASN A CA  1 
ATOM   1895 C  C   . ASN A 1 248 ? -12.05366 -21.31191 37.24224  1.000 84.32606  ?  248  ASN A C   1 
ATOM   1896 O  O   . ASN A 1 248 ? -13.26911 -21.52080 37.22202  1.000 84.54076  ?  248  ASN A O   1 
ATOM   1897 C  CB  . ASN A 1 248 ? -11.67647 -23.67108 38.04206  1.000 85.21888  ?  248  ASN A CB  1 
ATOM   1898 N  N   . SER A 1 249 ? -11.52577 -20.09254 37.16273  1.000 85.13548  ?  249  SER A N   1 
ATOM   1899 C  CA  . SER A 1 249 ? -12.30061 -18.86771 37.17691  1.000 79.22242  ?  249  SER A CA  1 
ATOM   1900 C  C   . SER A 1 249 ? -12.58755 -18.41739 35.75412  1.000 71.66284  ?  249  SER A C   1 
ATOM   1901 O  O   . SER A 1 249 ? -12.13665 -19.01898 34.77664  1.000 69.63553  ?  249  SER A O   1 
ATOM   1902 C  CB  . SER A 1 249 ? -11.54895 -17.77454 37.92762  1.000 82.93084  ?  249  SER A CB  1 
ATOM   1903 O  OG  . SER A 1 249 ? -10.33662 -17.46006 37.25526  1.000 78.52599  ?  249  SER A OG  1 
ATOM   1904 N  N   . SER A 1 250 ? -13.34278 -17.32632 35.64071  1.000 74.22895  ?  250  SER A N   1 
ATOM   1905 C  CA  . SER A 1 250 ? -13.61617 -16.75802 34.32916  1.000 71.42975  ?  250  SER A CA  1 
ATOM   1906 C  C   . SER A 1 250 ? -12.30939 -16.45283 33.60757  1.000 69.87146  ?  250  SER A C   1 
ATOM   1907 O  O   . SER A 1 250 ? -12.07449 -16.92432 32.48733  1.000 67.05948  ?  250  SER A O   1 
ATOM   1908 C  CB  . SER A 1 250 ? -14.47649 -15.49964 34.48968  1.000 72.61610  ?  250  SER A CB  1 
ATOM   1909 O  OG  . SER A 1 250 ? -15.04167 -15.06718 33.26331  1.000 72.94638  ?  250  SER A OG  1 
ATOM   1910 N  N   . LEU A 1 251 ? -11.41218 -15.73532 34.28706  1.000 67.72090  ?  251  LEU A N   1 
ATOM   1911 C  CA  . LEU A 1 251 ? -10.18380 -15.25610 33.67001  1.000 64.92080  ?  251  LEU A CA  1 
ATOM   1912 C  C   . LEU A 1 251 ? -9.25478  -16.40457 33.29873  1.000 61.02733  ?  251  LEU A C   1 
ATOM   1913 O  O   . LEU A 1 251 ? -8.68530  -16.40953 32.20272  1.000 58.28098  ?  251  LEU A O   1 
ATOM   1914 C  CB  . LEU A 1 251 ? -9.49766  -14.27148 34.61671  1.000 61.93953  ?  251  LEU A CB  1 
ATOM   1915 C  CG  . LEU A 1 251 ? -8.16702  -13.63110 34.23198  1.000 62.79479  ?  251  LEU A CG  1 
ATOM   1916 C  CD1 . LEU A 1 251 ? -8.31388  -12.81560 32.95897  1.000 55.94811  ?  251  LEU A CD1 1 
ATOM   1917 C  CD2 . LEU A 1 251 ? -7.67801  -12.74786 35.38715  1.000 58.99065  ?  251  LEU A CD2 1 
ATOM   1918 N  N   . ASN A 1 252 ? -9.08778  -17.38391 34.19347  1.000 62.73598  ?  252  ASN A N   1 
ATOM   1919 C  CA  . ASN A 1 252 ? -8.25110  -18.53781 33.87318  1.000 66.64979  ?  252  ASN A CA  1 
ATOM   1920 C  C   . ASN A 1 252 ? -8.80562  -19.28921 32.67045  1.000 61.39798  ?  252  ASN A C   1 
ATOM   1921 O  O   . ASN A 1 252 ? -8.04540  -19.74720 31.81048  1.000 57.18475  ?  252  ASN A O   1 
ATOM   1922 C  CB  . ASN A 1 252 ? -8.12488  -19.46250 35.08841  1.000 67.99549  ?  252  ASN A CB  1 
ATOM   1923 C  CG  . ASN A 1 252 ? -7.84678  -20.90794 34.69846  1.000 80.30219  ?  252  ASN A CG  1 
ATOM   1924 O  OD1 . ASN A 1 252 ? -8.77330  -21.70464 34.49837  1.000 77.66061  ?  252  ASN A OD1 1 
ATOM   1925 N  ND2 . ASN A 1 252 ? -6.56340  -21.25290 34.58012  1.000 79.11323  ?  252  ASN A ND2 1 
ATOM   1926 N  N   . GLN A 1 253 ? -10.13347 -19.39266 32.58122  1.000 64.48829  ?  253  GLN A N   1 
ATOM   1927 C  CA  . GLN A 1 253 ? -10.77506 -20.02582 31.43219  1.000 63.37007  ?  253  GLN A CA  1 
ATOM   1928 C  C   . GLN A 1 253 ? -10.45052 -19.29255 30.13419  1.000 59.49791  ?  253  GLN A C   1 
ATOM   1929 O  O   . GLN A 1 253 ? -10.11851 -19.91925 29.11969  1.000 53.91987  ?  253  GLN A O   1 
ATOM   1930 C  CB  . GLN A 1 253 ? -12.28725 -20.06647 31.65285  1.000 65.03775  ?  253  GLN A CB  1 
ATOM   1931 C  CG  . GLN A 1 253 ? -13.08646 -20.13485 30.36847  1.000 73.20815  ?  253  GLN A CG  1 
ATOM   1932 C  CD  . GLN A 1 253 ? -13.55257 -21.54768 30.03807  1.000 83.96834  ?  253  GLN A CD  1 
ATOM   1933 O  OE1 . GLN A 1 253 ? -14.22336 -22.19945 30.84528  1.000 85.08056  ?  253  GLN A OE1 1 
ATOM   1934 N  NE2 . GLN A 1 253 ? -13.16968 -22.03826 28.85640  1.000 80.60683  ?  253  GLN A NE2 1 
ATOM   1935 N  N   . GLU A 1 254 ? -10.56731 -17.95762 30.13795  1.000 58.14484  ?  254  GLU A N   1 
ATOM   1936 C  CA  . GLU A 1 254 ? -10.25573 -17.19847 28.92548  1.000 55.05772  ?  254  GLU A CA  1 
ATOM   1937 C  C   . GLU A 1 254 ? -8.77956  -17.31705 28.55945  1.000 49.59639  ?  254  GLU A C   1 
ATOM   1938 O  O   . GLU A 1 254 ? -8.42970  -17.43548 27.37605  1.000 44.19950  ?  254  GLU A O   1 
ATOM   1939 C  CB  . GLU A 1 254 ? -10.65439 -15.72826 29.08281  1.000 55.78880  ?  254  GLU A CB  1 
ATOM   1940 C  CG  . GLU A 1 254 ? -11.93138 -15.51846 29.87822  1.000 66.99180  ?  254  GLU A CG  1 
ATOM   1941 C  CD  . GLU A 1 254 ? -12.05822 -14.12062 30.48066  1.000 71.44459  ?  254  GLU A CD  1 
ATOM   1942 O  OE1 . GLU A 1 254 ? -12.45645 -13.18639 29.74350  1.000 77.89518  ?  254  GLU A OE1 1 
ATOM   1943 O  OE2 . GLU A 1 254 ? -11.75898 -13.94972 31.68260  1.000 74.44150  -1 254  GLU A OE2 1 
ATOM   1944 N  N   . ARG A 1 255 ? -7.89755  -17.27986 29.55935  1.000 47.52030  ?  255  ARG A N   1 
ATOM   1945 C  CA  . ARG A 1 255 ? -6.47779  -17.43396 29.27907  1.000 46.57748  ?  255  ARG A CA  1 
ATOM   1946 C  C   . ARG A 1 255 ? -6.19564  -18.79611 28.66932  1.000 49.89315  ?  255  ARG A C   1 
ATOM   1947 O  O   . ARG A 1 255 ? -5.35462  -18.91774 27.76635  1.000 44.20644  ?  255  ARG A O   1 
ATOM   1948 C  CB  . ARG A 1 255 ? -5.65812  -17.24124 30.54908  1.000 47.45310  ?  255  ARG A CB  1 
ATOM   1949 C  CG  . ARG A 1 255 ? -5.70983  -15.84851 31.10736  1.000 51.96574  ?  255  ARG A CG  1 
ATOM   1950 C  CD  . ARG A 1 255 ? -5.09861  -15.79925 32.48322  1.000 53.90119  ?  255  ARG A CD  1 
ATOM   1951 N  NE  . ARG A 1 255 ? -4.86235  -14.43092 32.92151  1.000 54.57060  ?  255  ARG A NE  1 
ATOM   1952 C  CZ  . ARG A 1 255 ? -4.75789  -14.07393 34.19367  1.000 62.16893  ?  255  ARG A CZ  1 
ATOM   1953 N  NH1 . ARG A 1 255 ? -4.92503  -14.95170 35.17020  1.000 64.70383  ?  255  ARG A NH1 1 
ATOM   1954 N  NH2 . ARG A 1 255 ? -4.48344  -12.80479 34.49619  1.000 53.58993  ?  255  ARG A NH2 1 
ATOM   1955 N  N   . HIS A 1 256 ? -6.89949  -19.83204 29.14779  1.000 48.83135  ?  256  HIS A N   1 
ATOM   1956 C  CA  . HIS A 1 256 ? -6.75024  -21.16258 28.56898  1.000 50.93730  ?  256  HIS A CA  1 
ATOM   1957 C  C   . HIS A 1 256 ? -7.22070  -21.18699 27.12120  1.000 48.69261  ?  256  HIS A C   1 
ATOM   1958 O  O   . HIS A 1 256 ? -6.57420  -21.78597 26.25072  1.000 51.66585  ?  256  HIS A O   1 
ATOM   1959 C  CB  . HIS A 1 256 ? -7.52539  -22.18673 29.39683  1.000 50.05286  ?  256  HIS A CB  1 
ATOM   1960 C  CG  . HIS A 1 256 ? -7.15971  -23.60369 29.08109  1.000 58.43971  ?  256  HIS A CG  1 
ATOM   1961 N  ND1 . HIS A 1 256 ? -7.88917  -24.38797 28.20922  1.000 56.43417  ?  256  HIS A ND1 1 
ATOM   1962 C  CD2 . HIS A 1 256 ? -6.12101  -24.36885 29.49622  1.000 56.46734  ?  256  HIS A CD2 1 
ATOM   1963 C  CE1 . HIS A 1 256 ? -7.32117  -25.57767 28.10855  1.000 56.13240  ?  256  HIS A CE1 1 
ATOM   1964 N  NE2 . HIS A 1 256 ? -6.24786  -25.59348 28.88122  1.000 59.12437  ?  256  HIS A NE2 1 
ATOM   1965 N  N   . ALA A 1 257 ? -8.35268  -20.54898 26.84758  1.000 47.95161  ?  257  ALA A N   1 
ATOM   1966 C  CA  . ALA A 1 257 ? -8.86242  -20.53253 25.48454  1.000 44.48224  ?  257  ALA A CA  1 
ATOM   1967 C  C   . ALA A 1 257 ? -7.86936  -19.85788 24.54737  1.000 44.81543  ?  257  ALA A C   1 
ATOM   1968 O  O   . ALA A 1 257 ? -7.61868  -20.33388 23.42879  1.000 50.30804  ?  257  ALA A O   1 
ATOM   1969 C  CB  . ALA A 1 257 ? -10.21841 -19.82572 25.45537  1.000 46.57789  ?  257  ALA A CB  1 
ATOM   1970 N  N   . ILE A 1 258 ? -7.27865  -18.75224 25.00019  1.000 45.19309  ?  258  ILE A N   1 
ATOM   1971 C  CA  . ILE A 1 258 ? -6.30676  -18.03409 24.18391  1.000 39.92472  ?  258  ILE A CA  1 
ATOM   1972 C  C   . ILE A 1 258 ? -5.08108  -18.90001 23.91925  1.000 43.09883  ?  258  ILE A C   1 
ATOM   1973 O  O   . ILE A 1 258 ? -4.60142  -18.99948 22.78048  1.000 40.72699  ?  258  ILE A O   1 
ATOM   1974 C  CB  . ILE A 1 258 ? -5.91954  -16.71790 24.86627  1.000 39.99031  ?  258  ILE A CB  1 
ATOM   1975 C  CG1 . ILE A 1 258 ? -6.96364  -15.64659 24.53848  1.000 38.09326  ?  258  ILE A CG1 1 
ATOM   1976 C  CG2 . ILE A 1 258 ? -4.51382  -16.31165 24.45051  1.000 38.61798  ?  258  ILE A CG2 1 
ATOM   1977 C  CD1 . ILE A 1 258 ? -7.22400  -14.72141 25.68203  1.000 34.07901  ?  258  ILE A CD1 1 
ATOM   1978 N  N   . LEU A 1 259 ? -4.54559  -19.52212 24.97549  1.000 44.89370  ?  259  LEU A N   1 
ATOM   1979 C  CA  . LEU A 1 259 ? -3.37304  -20.37491 24.81617  1.000 43.74850  ?  259  LEU A CA  1 
ATOM   1980 C  C   . LEU A 1 259 ? -3.63573  -21.49038 23.81571  1.000 44.72530  ?  259  LEU A C   1 
ATOM   1981 O  O   . LEU A 1 259 ? -2.77254  -21.79778 22.98058  1.000 42.28656  ?  259  LEU A O   1 
ATOM   1982 C  CB  . LEU A 1 259 ? -2.95870  -20.95593 26.16405  1.000 41.90268  ?  259  LEU A CB  1 
ATOM   1983 C  CG  . LEU A 1 259 ? -2.31083  -19.91591 27.07842  1.000 44.69939  ?  259  LEU A CG  1 
ATOM   1984 C  CD1 . LEU A 1 259 ? -2.30400  -20.39683 28.52075  1.000 35.16161  ?  259  LEU A CD1 1 
ATOM   1985 C  CD2 . LEU A 1 259 ? -0.90790  -19.59405 26.58950  1.000 40.17342  ?  259  LEU A CD2 1 
ATOM   1986 N  N   . GLN A 1 260 ? -4.81963  -22.11469 23.88917  1.000 46.49816  ?  260  GLN A N   1 
ATOM   1987 C  CA  . GLN A 1 260 ? -5.12418  -23.20247 22.95846  1.000 48.77865  ?  260  GLN A CA  1 
ATOM   1988 C  C   . GLN A 1 260 ? -5.18115  -22.69538 21.52455  1.000 43.79951  ?  260  GLN A C   1 
ATOM   1989 O  O   . GLN A 1 260 ? -4.66396  -23.34509 20.60411  1.000 45.57161  ?  260  GLN A O   1 
ATOM   1990 C  CB  . GLN A 1 260 ? -6.43655  -23.88249 23.34697  1.000 49.73885  ?  260  GLN A CB  1 
ATOM   1991 C  CG  . GLN A 1 260 ? -6.35363  -24.63999 24.66634  1.000 52.32337  ?  260  GLN A CG  1 
ATOM   1992 C  CD  . GLN A 1 260 ? -5.16278  -25.60404 24.72934  1.000 60.02515  ?  260  GLN A CD  1 
ATOM   1993 O  OE1 . GLN A 1 260 ? -4.97113  -26.44028 23.83044  1.000 57.76525  ?  260  GLN A OE1 1 
ATOM   1994 N  NE2 . GLN A 1 260 ? -4.36205  -25.49654 25.79877  1.000 59.70761  ?  260  GLN A NE2 1 
ATOM   1995 N  N   . GLN A 1 261 ? -5.80359  -21.53624 21.30950  1.000 38.94662  ?  261  GLN A N   1 
ATOM   1996 C  CA  . GLN A 1 261 ? -5.82053  -20.99889 19.95551  1.000 43.04257  ?  261  GLN A CA  1 
ATOM   1997 C  C   . GLN A 1 261 ? -4.41166  -20.63099 19.46728  1.000 45.51687  ?  261  GLN A C   1 
ATOM   1998 O  O   . GLN A 1 261 ? -4.12049  -20.77748 18.27443  1.000 48.64094  ?  261  GLN A O   1 
ATOM   1999 C  CB  . GLN A 1 261 ? -6.78157  -19.81504 19.87749  1.000 46.54943  ?  261  GLN A CB  1 
ATOM   2000 C  CG  . GLN A 1 261 ? -8.24407  -20.22860 19.95804  1.000 44.62339  ?  261  GLN A CG  1 
ATOM   2001 C  CD  . GLN A 1 261 ? -9.19603  -19.06035 19.83253  1.000 53.73118  ?  261  GLN A CD  1 
ATOM   2002 O  OE1 . GLN A 1 261 ? -9.46836  -18.57386 18.73454  1.000 57.97422  ?  261  GLN A OE1 1 
ATOM   2003 N  NE2 . GLN A 1 261 ? -9.71096  -18.60324 20.95873  1.000 50.74412  ?  261  GLN A NE2 1 
ATOM   2004 N  N   . CYS A 1 262 ? -3.51390  -20.20105 20.36734  1.000 40.26430  ?  262  CYS A N   1 
ATOM   2005 C  CA  . CYS A 1 262 ? -2.14050  -19.91130 19.95416  1.000 40.20623  ?  262  CYS A CA  1 
ATOM   2006 C  C   . CYS A 1 262 ? -1.40888  -21.18512 19.53395  1.000 48.22891  ?  262  CYS A C   1 
ATOM   2007 O  O   . CYS A 1 262 ? -0.69602  -21.20460 18.50947  1.000 44.93744  ?  262  CYS A O   1 
ATOM   2008 C  CB  . CYS A 1 262 ? -1.38778  -19.20507 21.08594  1.000 37.99911  ?  262  CYS A CB  1 
ATOM   2009 S  SG  . CYS A 1 262 ? -1.88139  -17.44986 21.35419  1.000 39.86198  ?  262  CYS A SG  1 
ATOM   2010 N  N   . PHE A 1 263 ? -1.57607  -22.25843 20.31819  1.000 42.96363  ?  263  PHE A N   1 
ATOM   2011 C  CA  . PHE A 1 263 ? -0.90936  -23.51391 19.99858  1.000 43.73390  ?  263  PHE A CA  1 
ATOM   2012 C  C   . PHE A 1 263 ? -1.43272  -24.07690 18.68119  1.000 45.72064  ?  263  PHE A C   1 
ATOM   2013 O  O   . PHE A 1 263 ? -0.66156  -24.59728 17.86650  1.000 48.75969  ?  263  PHE A O   1 
ATOM   2014 C  CB  . PHE A 1 263 ? -1.09273  -24.51787 21.13733  1.000 44.02941  ?  263  PHE A CB  1 
ATOM   2015 C  CG  . PHE A 1 263 ? -0.57273  -24.04287 22.46542  1.000 44.55085  ?  263  PHE A CG  1 
ATOM   2016 C  CD1 . PHE A 1 263 ? 0.27713   -22.93590 22.54977  1.000 46.76189  ?  263  PHE A CD1 1 
ATOM   2017 C  CD2 . PHE A 1 263 ? -0.92205  -24.71029 23.63399  1.000 44.19206  ?  263  PHE A CD2 1 
ATOM   2018 C  CE1 . PHE A 1 263 ? 0.75828   -22.48851 23.77608  1.000 43.82935  ?  263  PHE A CE1 1 
ATOM   2019 C  CE2 . PHE A 1 263 ? -0.44990  -24.28527 24.87175  1.000 46.36179  ?  263  PHE A CE2 1 
ATOM   2020 C  CZ  . PHE A 1 263 ? 0.40264   -23.16523 24.94621  1.000 50.77961  ?  263  PHE A CZ  1 
ATOM   2021 N  N   . SER A 1 264 ? -2.73902  -23.94748 18.44020  1.000 49.72174  ?  264  SER A N   1 
ATOM   2022 C  CA  . SER A 1 264 ? -3.30939  -24.38375 17.16617  1.000 51.57432  ?  264  SER A CA  1 
ATOM   2023 C  C   . SER A 1 264 ? -2.76547  -23.56499 16.00503  1.000 50.60078  ?  264  SER A C   1 
ATOM   2024 O  O   . SER A 1 264 ? -2.40179  -24.11192 14.95685  1.000 52.38366  ?  264  SER A O   1 
ATOM   2025 C  CB  . SER A 1 264 ? -4.83494  -24.28029 17.20845  1.000 52.07237  ?  264  SER A CB  1 
ATOM   2026 O  OG  . SER A 1 264 ? -5.37386  -25.24517 18.09824  1.000 62.46078  ?  264  SER A OG  1 
ATOM   2027 N  N   . ALA A 1 265 ? -2.72185  -22.24315 16.15870  1.000 47.19562  ?  265  ALA A N   1 
ATOM   2028 C  CA  . ALA A 1 265 ? -2.33079  -21.42161 15.02290  1.000 47.45630  ?  265  ALA A CA  1 
ATOM   2029 C  C   . ALA A 1 265 ? -0.84414  -21.54168 14.71269  1.000 42.36571  ?  265  ALA A C   1 
ATOM   2030 O  O   . ALA A 1 265 ? -0.45014  -21.26701 13.57752  1.000 46.23376  ?  265  ALA A O   1 
ATOM   2031 C  CB  . ALA A 1 265 ? -2.71153  -19.95658 15.26184  1.000 48.14090  ?  265  ALA A CB  1 
ATOM   2032 N  N   . ALA A 1 266 ? -0.02350  -21.97388 15.68220  1.000 41.10959  ?  266  ALA A N   1 
ATOM   2033 C  CA  . ALA A 1 266 ? 1.40836   -22.11654 15.43361  1.000 40.59531  ?  266  ALA A CA  1 
ATOM   2034 C  C   . ALA A 1 266 ? 1.71069   -23.06525 14.27255  1.000 46.41604  ?  266  ALA A C   1 
ATOM   2035 O  O   . ALA A 1 266 ? 2.75871   -22.93901 13.62473  1.000 44.65682  ?  266  ALA A O   1 
ATOM   2036 C  CB  . ALA A 1 266 ? 2.11298   -22.59651 16.70616  1.000 40.35681  ?  266  ALA A CB  1 
ATOM   2037 N  N   . GLU A 1 267 ? 0.82041   -24.01358 13.98483  1.000 45.28549  ?  267  GLU A N   1 
ATOM   2038 C  CA  . GLU A 1 267 ? 1.07913   -24.95939 12.90154  1.000 50.22440  ?  267  GLU A CA  1 
ATOM   2039 C  C   . GLU A 1 267 ? 0.89167   -24.34616 11.52078  1.000 49.63266  ?  267  GLU A C   1 
ATOM   2040 O  O   . GLU A 1 267 ? 1.35091   -24.93171 10.53262  1.000 48.84957  ?  267  GLU A O   1 
ATOM   2041 C  CB  . GLU A 1 267 ? 0.16589   -26.18946 13.02109  1.000 53.19961  ?  267  GLU A CB  1 
ATOM   2042 C  CG  . GLU A 1 267 ? 0.39303   -27.05530 14.25862  1.000 58.49937  ?  267  GLU A CG  1 
ATOM   2043 C  CD  . GLU A 1 267 ? 1.86719   -27.41103 14.47979  1.000 65.47919  ?  267  GLU A CD  1 
ATOM   2044 O  OE1 . GLU A 1 267 ? 2.23017   -28.61070 14.37408  1.000 69.72456  ?  267  GLU A OE1 1 
ATOM   2045 O  OE2 . GLU A 1 267 ? 2.66729   -26.49722 14.79038  1.000 68.84007  -1 267  GLU A OE2 1 
ATOM   2046 N  N   . THR A 1 268 ? 0.22673   -23.19845 11.42789  1.000 43.20727  ?  268  THR A N   1 
ATOM   2047 C  CA  . THR A 1 268 ? -0.14487  -22.64857 10.12982  1.000 46.14338  ?  268  THR A CA  1 
ATOM   2048 C  C   . THR A 1 268 ? 1.06994   -22.14644 9.35609   1.000 46.30058  ?  268  THR A C   1 
ATOM   2049 O  O   . THR A 1 268 ? 1.97007   -21.50430 9.91564   1.000 45.31015  ?  268  THR A O   1 
ATOM   2050 C  CB  . THR A 1 268 ? -1.14414  -21.51604 10.32292  1.000 44.52715  ?  268  THR A CB  1 
ATOM   2051 O  OG1 . THR A 1 268 ? -2.37118  -22.06650 10.79239  1.000 52.67461  ?  268  THR A OG1 1 
ATOM   2052 C  CG2 . THR A 1 268 ? -1.37557  -20.76446 9.03341   1.000 47.13738  ?  268  THR A CG2 1 
ATOM   2053 N  N   . ASP A 1 269 ? 1.08320   -22.42891 8.05098   1.000 47.02231  ?  269  ASP A N   1 
ATOM   2054 C  CA  . ASP A 1 269 ? 2.17432   -21.98828 7.18133   1.000 50.62989  ?  269  ASP A CA  1 
ATOM   2055 C  C   . ASP A 1 269 ? 1.86356   -20.60510 6.63014   1.000 47.14240  ?  269  ASP A C   1 
ATOM   2056 O  O   . ASP A 1 269 ? 1.49452   -20.43811 5.46887   1.000 51.75419  ?  269  ASP A O   1 
ATOM   2057 C  CB  . ASP A 1 269 ? 2.40576   -22.97248 6.04795   1.000 47.19583  ?  269  ASP A CB  1 
ATOM   2058 C  CG  . ASP A 1 269 ? 3.71009   -22.70015 5.31127   1.000 61.51159  ?  269  ASP A CG  1 
ATOM   2059 O  OD1 . ASP A 1 269 ? 4.40397   -21.72225 5.68359   1.000 65.54554  -1 269  ASP A OD1 1 
ATOM   2060 O  OD2 . ASP A 1 269 ? 4.04845   -23.45096 4.36768   1.000 67.75274  -1 269  ASP A OD2 1 
ATOM   2061 N  N   . ARG A 1 270 ? 2.04837   -19.59712 7.47852   1.000 45.32290  ?  270  ARG A N   1 
ATOM   2062 C  CA  . ARG A 1 270 ? 1.83971   -18.20229 7.11619   1.000 34.93468  ?  270  ARG A CA  1 
ATOM   2063 C  C   . ARG A 1 270 ? 2.92343   -17.36564 7.77698   1.000 39.18101  ?  270  ARG A C   1 
ATOM   2064 O  O   . ARG A 1 270 ? 3.61355   -17.84438 8.67268   1.000 41.59384  ?  270  ARG A O   1 
ATOM   2065 C  CB  . ARG A 1 270 ? 0.45522   -17.71862 7.53746   1.000 44.97790  ?  270  ARG A CB  1 
ATOM   2066 C  CG  . ARG A 1 270 ? -0.66377  -18.20325 6.62514   1.000 56.75367  ?  270  ARG A CG  1 
ATOM   2067 C  CD  . ARG A 1 270 ? -1.82496  -17.22505 6.62950   1.000 59.27053  ?  270  ARG A CD  1 
ATOM   2068 N  NE  . ARG A 1 270 ? -2.06098  -16.67641 5.30078   1.000 69.66574  ?  270  ARG A NE  1 
ATOM   2069 C  CZ  . ARG A 1 270 ? -2.69060  -15.53259 5.06381   1.000 70.62831  ?  270  ARG A CZ  1 
ATOM   2070 N  NH1 . ARG A 1 270 ? -3.15051  -14.77789 6.05404   1.000 55.82837  ?  270  ARG A NH1 1 
ATOM   2071 N  NH2 . ARG A 1 270 ? -2.85574  -15.13296 3.80276   1.000 69.24481  ?  270  ARG A NH2 1 
ATOM   2072 N  N   . THR A 1 271 ? 3.08527   -16.10802 7.31624   1.000 35.57982  ?  271  THR A N   1 
ATOM   2073 C  CA  . THR A 1 271 ? 4.16781   -15.24901 7.77741   1.000 38.41725  ?  271  THR A CA  1 
ATOM   2074 C  C   . THR A 1 271 ? 3.71789   -14.06024 8.61792   1.000 38.03223  ?  271  THR A C   1 
ATOM   2075 O  O   . THR A 1 271 ? 4.57175   -13.44771 9.27367   1.000 34.65271  ?  271  THR A O   1 
ATOM   2076 C  CB  . THR A 1 271 ? 4.99220   -14.70098 6.59449   1.000 27.42208  ?  271  THR A CB  1 
ATOM   2077 O  OG1 . THR A 1 271 ? 4.18488   -13.80659 5.82830   1.000 35.74771  ?  271  THR A OG1 1 
ATOM   2078 C  CG2 . THR A 1 271 ? 5.46886   -15.81102 5.69124   1.000 35.26301  ?  271  THR A CG2 1 
ATOM   2079 N  N   . LEU A 1 272 ? 2.42238   -13.71269 8.60157   1.000 33.37675  ?  272  LEU A N   1 
ATOM   2080 C  CA  . LEU A 1 272 ? 1.88531   -12.53443 9.28489   1.000 32.36083  ?  272  LEU A CA  1 
ATOM   2081 C  C   . LEU A 1 272 ? 0.70133   -12.93702 10.15759  1.000 32.56133  ?  272  LEU A C   1 
ATOM   2082 O  O   . LEU A 1 272 ? -0.35650  -13.29592 9.64297   1.000 38.15319  ?  272  LEU A O   1 
ATOM   2083 C  CB  . LEU A 1 272 ? 1.45695   -11.46232 8.27660   1.000 31.44451  ?  272  LEU A CB  1 
ATOM   2084 C  CG  . LEU A 1 272 ? 2.60190   -10.99666 7.36290   1.000 39.13424  ?  272  LEU A CG  1 
ATOM   2085 C  CD1 . LEU A 1 272 ? 2.08997   -10.16876 6.18679   1.000 41.87319  ?  272  LEU A CD1 1 
ATOM   2086 C  CD2 . LEU A 1 272 ? 3.64292   -10.20593 8.14703   1.000 27.02144  ?  272  LEU A CD2 1 
ATOM   2087 N  N   . PHE A 1 273 ? 0.84959   -12.83830 11.46718  1.000 33.59055  ?  273  PHE A N   1 
ATOM   2088 C  CA  . PHE A 1 273 ? -0.22979  -13.16103 12.38223  1.000 30.21641  ?  273  PHE A CA  1 
ATOM   2089 C  C   . PHE A 1 273 ? -0.52746  -11.95809 13.26577  1.000 32.40341  ?  273  PHE A C   1 
ATOM   2090 O  O   . PHE A 1 273 ? 0.29959   -11.05395 13.42913  1.000 33.58929  ?  273  PHE A O   1 
ATOM   2091 C  CB  . PHE A 1 273 ? 0.11727   -14.34341 13.28666  1.000 32.58948  ?  273  PHE A CB  1 
ATOM   2092 C  CG  . PHE A 1 273 ? 0.43984   -15.63056 12.55452  1.000 35.48549  ?  273  PHE A CG  1 
ATOM   2093 C  CD1 . PHE A 1 273 ? 1.71310   -15.86877 12.06578  1.000 32.30827  ?  273  PHE A CD1 1 
ATOM   2094 C  CD2 . PHE A 1 273 ? -0.53529  -16.61749 12.39700  1.000 34.86504  ?  273  PHE A CD2 1 
ATOM   2095 C  CE1 . PHE A 1 273 ? 2.02527   -17.07870 11.41013  1.000 34.84632  ?  273  PHE A CE1 1 
ATOM   2096 C  CE2 . PHE A 1 273 ? -0.23708  -17.82661 11.73769  1.000 33.42287  ?  273  PHE A CE2 1 
ATOM   2097 C  CZ  . PHE A 1 273 ? 1.04919   -18.05122 11.25238  1.000 32.67477  ?  273  PHE A CZ  1 
ATOM   2098 N  N   . SER A 1 274 ? -1.72612  -11.95182 13.82526  1.000 33.42727  ?  274  SER A N   1 
ATOM   2099 C  CA  . SER A 1 274 ? -2.08121  -11.02810 14.88408  1.000 31.39321  ?  274  SER A CA  1 
ATOM   2100 C  C   . SER A 1 274 ? -2.67057  -11.80908 16.04368  1.000 30.84336  ?  274  SER A C   1 
ATOM   2101 O  O   . SER A 1 274 ? -3.22873  -12.90262 15.86288  1.000 29.92733  ?  274  SER A O   1 
ATOM   2102 C  CB  . SER A 1 274 ? -3.06415  -9.97468  14.42005  1.000 28.97098  ?  274  SER A CB  1 
ATOM   2103 O  OG  . SER A 1 274 ? -4.31801  -10.53507 14.12420  1.000 33.92274  ?  274  SER A OG  1 
ATOM   2104 N  N   . LEU A 1 275 ? -2.51339  -11.23562 17.23717  1.000 30.28878  ?  275  LEU A N   1 
ATOM   2105 C  CA  . LEU A 1 275 ? -2.95910  -11.83045 18.49909  1.000 30.80417  ?  275  LEU A CA  1 
ATOM   2106 C  C   . LEU A 1 275 ? -3.63657  -10.70392 19.26648  1.000 33.68948  ?  275  LEU A C   1 
ATOM   2107 O  O   . LEU A 1 275 ? -2.96161  -9.83484  19.83481  1.000 29.21189  ?  275  LEU A O   1 
ATOM   2108 C  CB  . LEU A 1 275 ? -1.79127  -12.41944 19.28124  1.000 30.62736  ?  275  LEU A CB  1 
ATOM   2109 C  CG  . LEU A 1 275 ? -2.00523  -12.94404 20.70071  1.000 36.93257  ?  275  LEU A CG  1 
ATOM   2110 C  CD1 . LEU A 1 275 ? -3.15006  -13.92503 20.74440  1.000 33.30289  ?  275  LEU A CD1 1 
ATOM   2111 C  CD2 . LEU A 1 275 ? -0.72677  -13.62926 21.17796  1.000 40.25160  ?  275  LEU A CD2 1 
ATOM   2112 N  N   . THR A 1 276 ? -4.96095  -10.71100 19.24954  1.000 29.82536  ?  276  THR A N   1 
ATOM   2113 C  CA  . THR A 1 276 ? -5.77679  -9.66914  19.85206  1.000 34.50479  ?  276  THR A CA  1 
ATOM   2114 C  C   . THR A 1 276 ? -6.48021  -10.28029 21.04837  1.000 35.32622  ?  276  THR A C   1 
ATOM   2115 O  O   . THR A 1 276 ? -7.28581  -11.19975 20.88761  1.000 34.98341  ?  276  THR A O   1 
ATOM   2116 C  CB  . THR A 1 276 ? -6.78211  -9.10941  18.84783  1.000 37.58148  ?  276  THR A CB  1 
ATOM   2117 O  OG1 . THR A 1 276 ? -6.07757  -8.66426  17.68195  1.000 41.04186  ?  276  THR A OG1 1 
ATOM   2118 C  CG2 . THR A 1 276 ? -7.55494  -7.93574  19.44917  1.000 35.33317  ?  276  THR A CG2 1 
ATOM   2119 N  N   . VAL A 1 277 ? -6.16111  -9.78593  22.23966  1.000 32.53658  ?  277  VAL A N   1 
ATOM   2120 C  CA  . VAL A 1 277 ? -6.69267  -10.35094 23.47617  1.000 32.06693  ?  277  VAL A CA  1 
ATOM   2121 C  C   . VAL A 1 277 ? -7.14536  -9.22963  24.39900  1.000 36.23861  ?  277  VAL A C   1 
ATOM   2122 O  O   . VAL A 1 277 ? -6.81786  -8.05370  24.19449  1.000 35.50288  ?  277  VAL A O   1 
ATOM   2123 C  CB  . VAL A 1 277 ? -5.65477  -11.24484 24.17878  1.000 40.20996  ?  277  VAL A CB  1 
ATOM   2124 C  CG1 . VAL A 1 277 ? -5.38457  -12.49909 23.33189  1.000 38.92158  ?  277  VAL A CG1 1 
ATOM   2125 C  CG2 . VAL A 1 277 ? -4.38528  -10.49872 24.37481  1.000 38.57991  ?  277  VAL A CG2 1 
ATOM   2126 N  N   . PRO A 1 278 ? -7.96355  -9.55903  25.39425  1.000 40.48847  ?  278  PRO A N   1 
ATOM   2127 C  CA  . PRO A 1 278 ? -8.26670  -8.57080  26.43199  1.000 38.41503  ?  278  PRO A CA  1 
ATOM   2128 C  C   . PRO A 1 278 ? -7.03886  -8.30220  27.29102  1.000 38.58173  ?  278  PRO A C   1 
ATOM   2129 O  O   . PRO A 1 278 ? -6.16470  -9.15947  27.45637  1.000 37.22139  ?  278  PRO A O   1 
ATOM   2130 C  CB  . PRO A 1 278 ? -9.40051  -9.22299  27.23846  1.000 36.71561  ?  278  PRO A CB  1 
ATOM   2131 C  CG  . PRO A 1 278 ? -9.36609  -10.65907 26.89376  1.000 41.73082  ?  278  PRO A CG  1 
ATOM   2132 C  CD  . PRO A 1 278 ? -8.74391  -10.80064 25.54524  1.000 38.55011  ?  278  PRO A CD  1 
ATOM   2133 N  N   . THR A 1 279 ? -6.97759  -7.09002  27.83972  1.000 34.48472  ?  279  THR A N   1 
ATOM   2134 C  CA  . THR A 1 279 ? -5.90135  -6.75052  28.76670  1.000 39.26644  ?  279  THR A CA  1 
ATOM   2135 C  C   . THR A 1 279 ? -5.90965  -7.72637  29.93441  1.000 37.23575  ?  279  THR A C   1 
ATOM   2136 O  O   . THR A 1 279 ? -6.97324  -8.16502  30.38416  1.000 36.86007  ?  279  THR A O   1 
ATOM   2137 C  CB  . THR A 1 279 ? -6.06709  -5.32278  29.30660  1.000 36.03982  ?  279  THR A CB  1 
ATOM   2138 O  OG1 . THR A 1 279 ? -7.40251  -5.14392  29.78034  1.000 39.19296  ?  279  THR A OG1 1 
ATOM   2139 C  CG2 . THR A 1 279 ? -5.80362  -4.28339  28.23422  1.000 35.94566  ?  279  THR A CG2 1 
ATOM   2140 N  N   . GLY A 1 280 ? -4.72130  -8.07439  30.42532  1.000 36.87701  ?  280  GLY A N   1 
ATOM   2141 C  CA  . GLY A 1 280 ? -4.66294  -9.10651  31.44048  1.000 38.74378  ?  280  GLY A CA  1 
ATOM   2142 C  C   . GLY A 1 280 ? -4.98188  -10.49775 30.92845  1.000 44.89565  ?  280  GLY A C   1 
ATOM   2143 O  O   . GLY A 1 280 ? -5.16788  -11.41628 31.73291  1.000 43.64554  ?  280  GLY A O   1 
ATOM   2144 N  N   . GLY A 1 281 ? -5.04346  -10.68567 29.61202  1.000 39.93664  ?  281  GLY A N   1 
ATOM   2145 C  CA  . GLY A 1 281 ? -5.36300  -11.96450 29.01646  1.000 37.74118  ?  281  GLY A CA  1 
ATOM   2146 C  C   . GLY A 1 281 ? -4.18210  -12.87061 28.73355  1.000 42.66682  ?  281  GLY A C   1 
ATOM   2147 O  O   . GLY A 1 281 ? -4.37143  -13.91152 28.09818  1.000 38.36030  ?  281  GLY A O   1 
ATOM   2148 N  N   . GLY A 1 282 ? -2.97057  -12.52229 29.17815  1.000 44.44586  ?  282  GLY A N   1 
ATOM   2149 C  CA  . GLY A 1 282 ? -1.82267  -13.38618 28.95759  1.000 40.78805  ?  282  GLY A CA  1 
ATOM   2150 C  C   . GLY A 1 282 ? -1.12891  -13.16415 27.64072  1.000 40.35056  ?  282  GLY A C   1 
ATOM   2151 O  O   . GLY A 1 282 ? -0.52323  -14.09849 27.09814  1.000 41.26974  ?  282  GLY A O   1 
ATOM   2152 N  N   . LYS A 1 283 ? -1.17903  -11.93801 27.12437  1.000 38.78237  ?  283  LYS A N   1 
ATOM   2153 C  CA  . LYS A 1 283 ? -0.62232  -11.60655 25.81472  1.000 40.02519  ?  283  LYS A CA  1 
ATOM   2154 C  C   . LYS A 1 283 ? 0.82998   -12.07162 25.66432  1.000 35.69770  ?  283  LYS A C   1 
ATOM   2155 O  O   . LYS A 1 283 ? 1.18477   -12.70851 24.66604  1.000 32.05018  ?  283  LYS A O   1 
ATOM   2156 C  CB  . LYS A 1 283 ? -0.76475  -10.09525 25.62538  1.000 35.35587  ?  283  LYS A CB  1 
ATOM   2157 C  CG  . LYS A 1 283 ? -0.48863  -9.49762  24.28218  1.000 46.28370  ?  283  LYS A CG  1 
ATOM   2158 C  CD  . LYS A 1 283 ? -0.64413  -7.93257  24.37816  1.000 36.03718  ?  283  LYS A CD  1 
ATOM   2159 C  CE  . LYS A 1 283 ? 0.36398   -7.32085  25.34924  1.000 42.82739  ?  283  LYS A CE  1 
ATOM   2160 N  NZ  . LYS A 1 283 ? 0.24061   -5.82183  25.42019  1.000 46.99815  ?  283  LYS A NZ  1 
ATOM   2161 N  N   . THR A 1 284 ? 1.67910   -11.79632 26.65886  1.000 33.56362  ?  284  THR A N   1 
ATOM   2162 C  CA  . THR A 1 284 ? 3.10451   -12.09858 26.50911  1.000 38.28371  ?  284  THR A CA  1 
ATOM   2163 C  C   . THR A 1 284 ? 3.36876   -13.59955 26.50799  1.000 37.02497  ?  284  THR A C   1 
ATOM   2164 O  O   . THR A 1 284 ? 4.05069   -14.12435 25.61833  1.000 35.14966  ?  284  THR A O   1 
ATOM   2165 C  CB  . THR A 1 284 ? 3.91615   -11.42949 27.61958  1.000 39.36902  ?  284  THR A CB  1 
ATOM   2166 O  OG1 . THR A 1 284 ? 3.79845   -10.01159 27.49871  1.000 41.91348  ?  284  THR A OG1 1 
ATOM   2167 C  CG2 . THR A 1 284 ? 5.39798   -11.83085 27.51782  1.000 34.00108  ?  284  THR A CG2 1 
ATOM   2168 N  N   . LEU A 1 285 ? 2.83450   -14.30598 27.50218  1.000 38.35017  ?  285  LEU A N   1 
ATOM   2169 C  CA  . LEU A 1 285 ? 3.08508   -15.73845 27.61220  1.000 34.55428  ?  285  LEU A CA  1 
ATOM   2170 C  C   . LEU A 1 285 ? 2.46223   -16.50805 26.44890  1.000 33.65258  ?  285  LEU A C   1 
ATOM   2171 O  O   . LEU A 1 285 ? 3.05135   -17.47585 25.95340  1.000 38.60754  ?  285  LEU A O   1 
ATOM   2172 C  CB  . LEU A 1 285 ? 2.56064   -16.24029 28.95231  1.000 36.48191  ?  285  LEU A CB  1 
ATOM   2173 C  CG  . LEU A 1 285 ? 3.49509   -16.08516 30.15097  1.000 37.94560  ?  285  LEU A CG  1 
ATOM   2174 C  CD1 . LEU A 1 285 ? 2.84672   -16.67168 31.40064  1.000 41.34671  ?  285  LEU A CD1 1 
ATOM   2175 C  CD2 . LEU A 1 285 ? 4.83511   -16.78044 29.88263  1.000 39.54465  ?  285  LEU A CD2 1 
ATOM   2176 N  N   . ALA A 1 286 ? 1.28774   -16.08212 25.97709  1.000 36.25802  ?  286  ALA A N   1 
ATOM   2177 C  CA  . ALA A 1 286 ? 0.67226   -16.76265 24.83623  1.000 37.42690  ?  286  ALA A CA  1 
ATOM   2178 C  C   . ALA A 1 286 ? 1.44409   -16.49402 23.55078  1.000 35.74495  ?  286  ALA A C   1 
ATOM   2179 O  O   . ALA A 1 286 ? 1.60170   -17.38787 22.70671  1.000 33.03861  ?  286  ALA A O   1 
ATOM   2180 C  CB  . ALA A 1 286 ? -0.79342  -16.33973 24.68796  1.000 34.27188  ?  286  ALA A CB  1 
ATOM   2181 N  N   . SER A 1 287 ? 1.91350   -15.26111 23.36783  1.000 37.03894  ?  287  SER A N   1 
ATOM   2182 C  CA  . SER A 1 287 ? 2.70471   -14.97473 22.18042  1.000 34.63319  ?  287  SER A CA  1 
ATOM   2183 C  C   . SER A 1 287 ? 3.98969   -15.79038 22.18534  1.000 33.48576  ?  287  SER A C   1 
ATOM   2184 O  O   . SER A 1 287 ? 4.40374   -16.31553 21.14205  1.000 34.23149  ?  287  SER A O   1 
ATOM   2185 C  CB  . SER A 1 287 ? 3.00995   -13.47923 22.09853  1.000 33.24215  ?  287  SER A CB  1 
ATOM   2186 O  OG  . SER A 1 287 ? 4.17816   -13.19603 22.84509  1.000 38.02220  ?  287  SER A OG  1 
ATOM   2187 N  N   . LEU A 1 288 ? 4.62269   -15.92025 23.35668  1.000 32.54383  ?  288  LEU A N   1 
ATOM   2188 C  CA  . LEU A 1 288 ? 5.84566   -16.71858 23.46388  1.000 33.85541  ?  288  LEU A CA  1 
ATOM   2189 C  C   . LEU A 1 288 ? 5.58535   -18.18783 23.15681  1.000 31.02426  ?  288  LEU A C   1 
ATOM   2190 O  O   . LEU A 1 288 ? 6.39430   -18.82974 22.48172  1.000 36.36209  ?  288  LEU A O   1 
ATOM   2191 C  CB  . LEU A 1 288 ? 6.47188   -16.56828 24.84876  1.000 33.62599  ?  288  LEU A CB  1 
ATOM   2192 C  CG  . LEU A 1 288 ? 7.69879   -17.43938 25.18360  1.000 38.34498  ?  288  LEU A CG  1 
ATOM   2193 C  CD1 . LEU A 1 288 ? 8.89657   -17.14372 24.29725  1.000 32.95819  ?  288  LEU A CD1 1 
ATOM   2194 C  CD2 . LEU A 1 288 ? 8.10149   -17.30095 26.67041  1.000 36.88342  ?  288  LEU A CD2 1 
ATOM   2195 N  N   . GLY A 1 289 ? 4.47852   -18.74966 23.65865  1.000 32.07945  ?  289  GLY A N   1 
ATOM   2196 C  CA  . GLY A 1 289 ? 4.16367   -20.13822 23.32426  1.000 33.87340  ?  289  GLY A CA  1 
ATOM   2197 C  C   . GLY A 1 289 ? 3.90444   -20.35005 21.84114  1.000 33.06631  ?  289  GLY A C   1 
ATOM   2198 O  O   . GLY A 1 289 ? 4.46091   -21.27118 21.22210  1.000 36.51653  ?  289  GLY A O   1 
ATOM   2199 N  N   . PHE A 1 290 ? 3.07170   -19.48224 21.23931  1.000 32.96301  ?  290  PHE A N   1 
ATOM   2200 C  CA  . PHE A 1 290 ? 2.92061   -19.48815 19.78576  1.000 33.86181  ?  290  PHE A CA  1 
ATOM   2201 C  C   . PHE A 1 290 ? 4.27874   -19.47105 19.10023  1.000 34.72604  ?  290  PHE A C   1 
ATOM   2202 O  O   . PHE A 1 290 ? 4.51284   -20.20131 18.13226  1.000 34.10064  ?  290  PHE A O   1 
ATOM   2203 C  CB  . PHE A 1 290 ? 2.09975   -18.27701 19.30286  1.000 35.21934  ?  290  PHE A CB  1 
ATOM   2204 C  CG  . PHE A 1 290 ? 2.04390   -18.15635 17.78516  1.000 31.93494  ?  290  PHE A CG  1 
ATOM   2205 C  CD1 . PHE A 1 290 ? 3.09682   -17.61226 17.06941  1.000 32.97423  ?  290  PHE A CD1 1 
ATOM   2206 C  CD2 . PHE A 1 290 ? 0.95144   -18.62280 17.07993  1.000 33.31887  ?  290  PHE A CD2 1 
ATOM   2207 C  CE1 . PHE A 1 290 ? 3.05838   -17.55154 15.67289  1.000 35.04110  ?  290  PHE A CE1 1 
ATOM   2208 C  CE2 . PHE A 1 290 ? 0.90583   -18.54427 15.69717  1.000 34.65361  ?  290  PHE A CE2 1 
ATOM   2209 C  CZ  . PHE A 1 290 ? 1.96566   -18.01377 14.99727  1.000 31.97846  ?  290  PHE A CZ  1 
ATOM   2210 N  N   . ALA A 1 291 ? 5.17604   -18.60053 19.56894  1.000 33.29050  ?  291  ALA A N   1 
ATOM   2211 C  CA  . ALA A 1 291 ? 6.40567   -18.35575 18.82891  1.000 33.60688  ?  291  ALA A CA  1 
ATOM   2212 C  C   . ALA A 1 291 ? 7.33546   -19.55225 18.92629  1.000 35.52779  ?  291  ALA A C   1 
ATOM   2213 O  O   . ALA A 1 291 ? 7.97003   -19.93594 17.93822  1.000 30.00617  ?  291  ALA A O   1 
ATOM   2214 C  CB  . ALA A 1 291 ? 7.09879   -17.08950 19.34878  1.000 24.95059  ?  291  ALA A CB  1 
ATOM   2215 N  N   . LEU A 1 292 ? 7.43305   -20.14399 20.11684  1.000 34.07290  ?  292  LEU A N   1 
ATOM   2216 C  CA  . LEU A 1 292 ? 8.27898   -21.31606 20.29266  1.000 32.99167  ?  292  LEU A CA  1 
ATOM   2217 C  C   . LEU A 1 292 ? 7.80615   -22.45105 19.40508  1.000 34.50112  ?  292  LEU A C   1 
ATOM   2218 O  O   . LEU A 1 292 ? 8.60531   -23.05034 18.66936  1.000 38.00262  ?  292  LEU A O   1 
ATOM   2219 C  CB  . LEU A 1 292 ? 8.28151   -21.74419 21.75720  1.000 33.29962  ?  292  LEU A CB  1 
ATOM   2220 C  CG  . LEU A 1 292 ? 9.01266   -20.82910 22.71121  1.000 29.48920  ?  292  LEU A CG  1 
ATOM   2221 C  CD1 . LEU A 1 292 ? 8.54429   -21.08489 24.14835  1.000 34.20801  ?  292  LEU A CD1 1 
ATOM   2222 C  CD2 . LEU A 1 292 ? 10.50538  -21.05010 22.58835  1.000 35.14883  ?  292  LEU A CD2 1 
ATOM   2223 N  N   . LYS A 1 293 ? 6.49347   -22.72663 19.41507  1.000 34.31659  ?  293  LYS A N   1 
ATOM   2224 C  CA  . LYS A 1 293 ? 6.01110   -23.87185 18.64273  1.000 37.85628  ?  293  LYS A CA  1 
ATOM   2225 C  C   . LYS A 1 293 ? 6.14588   -23.63370 17.14308  1.000 38.79503  ?  293  LYS A C   1 
ATOM   2226 O  O   . LYS A 1 293 ? 6.57550   -24.53304 16.39298  1.000 41.37678  ?  293  LYS A O   1 
ATOM   2227 C  CB  . LYS A 1 293 ? 4.56425   -24.19157 19.00483  1.000 37.49918  ?  293  LYS A CB  1 
ATOM   2228 C  CG  . LYS A 1 293 ? 4.05575   -25.46033 18.32051  1.000 46.14616  ?  293  LYS A CG  1 
ATOM   2229 C  CD  . LYS A 1 293 ? 2.57452   -25.71235 18.61243  1.000 52.38112  ?  293  LYS A CD  1 
ATOM   2230 C  CE  . LYS A 1 293 ? 2.13659   -27.09212 18.13755  1.000 52.19365  ?  293  LYS A CE  1 
ATOM   2231 N  NZ  . LYS A 1 293 ? 0.64863   -27.16386 18.09275  1.000 54.13289  ?  293  LYS A NZ  1 
ATOM   2232 N  N   . HIS A 1 294 ? 5.79326   -22.42636 16.68880  1.000 34.10111  ?  294  HIS A N   1 
ATOM   2233 C  CA  . HIS A 1 294 ? 5.95728   -22.06167 15.28268  1.000 35.60022  ?  294  HIS A CA  1 
ATOM   2234 C  C   . HIS A 1 294 ? 7.42471   -22.12161 14.85548  1.000 36.13639  ?  294  HIS A C   1 
ATOM   2235 O  O   . HIS A 1 294 ? 7.74144   -22.59015 13.75440  1.000 35.25437  ?  294  HIS A O   1 
ATOM   2236 C  CB  . HIS A 1 294 ? 5.37784   -20.65797 15.07720  1.000 33.95162  ?  294  HIS A CB  1 
ATOM   2237 C  CG  . HIS A 1 294 ? 5.33074   -20.21347 13.65822  1.000 31.71312  ?  294  HIS A CG  1 
ATOM   2238 N  ND1 . HIS A 1 294 ? 4.25443   -20.46919 12.83804  1.000 35.86029  ?  294  HIS A ND1 1 
ATOM   2239 C  CD2 . HIS A 1 294 ? 6.21194   -19.50062 12.91465  1.000 35.18996  ?  294  HIS A CD2 1 
ATOM   2240 C  CE1 . HIS A 1 294 ? 4.48054   -19.94313 11.64348  1.000 35.72784  ?  294  HIS A CE1 1 
ATOM   2241 N  NE2 . HIS A 1 294 ? 5.65995   -19.34831 11.66582  1.000 34.81871  ?  294  HIS A NE2 1 
ATOM   2242 N  N   . ALA A 1 295 ? 8.33465   -21.64907 15.71662  1.000 30.65828  ?  295  ALA A N   1 
ATOM   2243 C  CA  . ALA A 1 295 ? 9.75621   -21.67333 15.40402  1.000 35.25204  ?  295  ALA A CA  1 
ATOM   2244 C  C   . ALA A 1 295 ? 10.24998  -23.09811 15.24569  1.000 37.43564  ?  295  ALA A C   1 
ATOM   2245 O  O   . ALA A 1 295 ? 11.05517  -23.39415 14.34886  1.000 39.21267  ?  295  ALA A O   1 
ATOM   2246 C  CB  . ALA A 1 295 ? 10.55142  -20.97220 16.51029  1.000 31.78783  ?  295  ALA A CB  1 
ATOM   2247 N  N   . LEU A 1 296 ? 9.79208   -23.98980 16.12274  1.000 31.44164  ?  296  LEU A N   1 
ATOM   2248 C  CA  . LEU A 1 296 ? 10.20178  -25.39180 16.01374  1.000 40.42703  ?  296  LEU A CA  1 
ATOM   2249 C  C   . LEU A 1 296 ? 9.65319   -26.03807 14.74775  1.000 36.23504  ?  296  LEU A C   1 
ATOM   2250 O  O   . LEU A 1 296 ? 10.35110  -26.81907 14.09856  1.000 43.91832  ?  296  LEU A O   1 
ATOM   2251 C  CB  . LEU A 1 296 ? 9.76201   -26.16404 17.25439  1.000 35.34495  ?  296  LEU A CB  1 
ATOM   2252 C  CG  . LEU A 1 296 ? 10.66013  -25.80179 18.44124  1.000 39.85543  ?  296  LEU A CG  1 
ATOM   2253 C  CD1 . LEU A 1 296 ? 10.12135  -26.36088 19.74513  1.000 47.45592  ?  296  LEU A CD1 1 
ATOM   2254 C  CD2 . LEU A 1 296 ? 12.11422  -26.21688 18.20126  1.000 38.44654  ?  296  LEU A CD2 1 
ATOM   2255 N  N   . LYS A 1 297 ? 8.41189   -25.73099 14.37444  1.000 37.29224  ?  297  LYS A N   1 
ATOM   2256 C  CA  . LYS A 1 297 ? 7.86094   -26.39516 13.19811  1.000 41.48637  ?  297  LYS A CA  1 
ATOM   2257 C  C   . LYS A 1 297 ? 8.46874   -25.87795 11.89534  1.000 43.34645  ?  297  LYS A C   1 
ATOM   2258 O  O   . LYS A 1 297 ? 8.59811   -26.63670 10.92837  1.000 43.37814  ?  297  LYS A O   1 
ATOM   2259 C  CB  . LYS A 1 297 ? 6.34401   -26.25362 13.14181  1.000 46.69064  ?  297  LYS A CB  1 
ATOM   2260 C  CG  . LYS A 1 297 ? 5.77059   -26.81423 11.83503  1.000 47.44171  ?  297  LYS A CG  1 
ATOM   2261 C  CD  . LYS A 1 297 ? 4.26301   -26.87379 11.79269  1.000 50.63072  ?  297  LYS A CD  1 
ATOM   2262 C  CE  . LYS A 1 297 ? 3.79860   -27.74484 10.62444  1.000 52.84142  ?  297  LYS A CE  1 
ATOM   2263 N  NZ  . LYS A 1 297 ? 2.33092   -27.68610 10.39205  1.000 55.14394  ?  297  LYS A NZ  1 
ATOM   2264 N  N   . PHE A 1 298 ? 8.85104   -24.60633 11.82620  1.000 41.12167  ?  298  PHE A N   1 
ATOM   2265 C  CA  . PHE A 1 298 ? 9.29080   -24.06524 10.54785  1.000 36.85135  ?  298  PHE A CA  1 
ATOM   2266 C  C   . PHE A 1 298 ? 10.75531  -23.64061 10.53732  1.000 37.56877  ?  298  PHE A C   1 
ATOM   2267 O  O   . PHE A 1 298 ? 11.14238  -22.79929 9.71928   1.000 41.21960  ?  298  PHE A O   1 
ATOM   2268 C  CB  . PHE A 1 298 ? 8.37324   -22.91363 10.15926  1.000 41.24962  ?  298  PHE A CB  1 
ATOM   2269 C  CG  . PHE A 1 298 ? 6.97258   -23.35441 9.88647   1.000 44.71929  ?  298  PHE A CG  1 
ATOM   2270 C  CD1 . PHE A 1 298 ? 6.63024   -23.89987 8.65192   1.000 44.04670  ?  298  PHE A CD1 1 
ATOM   2271 C  CD2 . PHE A 1 298 ? 6.00068   -23.27186 10.87233  1.000 41.72865  ?  298  PHE A CD2 1 
ATOM   2272 C  CE1 . PHE A 1 298 ? 5.33829   -24.31512 8.40117   1.000 41.96710  ?  298  PHE A CE1 1 
ATOM   2273 C  CE2 . PHE A 1 298 ? 4.70587   -23.69015 10.62303  1.000 43.74078  ?  298  PHE A CE2 1 
ATOM   2274 C  CZ  . PHE A 1 298 ? 4.37322   -24.21124 9.39234   1.000 47.08773  ?  298  PHE A CZ  1 
ATOM   2275 N  N   . GLY A 1 299 ? 11.57245  -24.19510 11.42864  1.000 37.56401  ?  299  GLY A N   1 
ATOM   2276 C  CA  . GLY A 1 299 ? 12.99537  -23.86243 11.47818  1.000 37.92718  ?  299  GLY A CA  1 
ATOM   2277 C  C   . GLY A 1 299 ? 13.35547  -22.40293 11.69499  1.000 40.71983  ?  299  GLY A C   1 
ATOM   2278 O  O   . GLY A 1 299 ? 14.33614  -21.92476 11.11371  1.000 41.94784  ?  299  GLY A O   1 
ATOM   2279 N  N   . LYS A 1 300 ? 12.59994  -21.67588 12.51998  1.000 37.22755  ?  300  LYS A N   1 
ATOM   2280 C  CA  . LYS A 1 300 ? 13.03463  -20.33609 12.90373  1.000 32.58673  ?  300  LYS A CA  1 
ATOM   2281 C  C   . LYS A 1 300 ? 14.12986  -20.46218 13.94079  1.000 34.87147  ?  300  LYS A C   1 
ATOM   2282 O  O   . LYS A 1 300 ? 14.11062  -21.37649 14.77213  1.000 36.97281  ?  300  LYS A O   1 
ATOM   2283 C  CB  . LYS A 1 300 ? 11.88210  -19.50470 13.46237  1.000 28.81655  ?  300  LYS A CB  1 
ATOM   2284 C  CG  . LYS A 1 300 ? 10.65813  -19.42336 12.56072  1.000 29.21988  ?  300  LYS A CG  1 
ATOM   2285 C  CD  . LYS A 1 300 ? 11.01599  -18.93693 11.18215  1.000 32.04831  ?  300  LYS A CD  1 
ATOM   2286 C  CE  . LYS A 1 300 ? 9.88568   -19.15339 10.18731  1.000 32.33137  ?  300  LYS A CE  1 
ATOM   2287 N  NZ  . LYS A 1 300 ? 10.35709  -18.84124 8.79074   1.000 33.50281  ?  300  LYS A NZ  1 
ATOM   2288 N  N   . LYS A 1 301 ? 15.10302  -19.55330 13.89114  1.000 34.70893  ?  301  LYS A N   1 
ATOM   2289 C  CA  . LYS A 1 301 ? 16.27248  -19.72792 14.74227  1.000 33.19227  ?  301  LYS A CA  1 
ATOM   2290 C  C   . LYS A 1 301 ? 16.20896  -18.95103 16.05334  1.000 33.46399  ?  301  LYS A C   1 
ATOM   2291 O  O   . LYS A 1 301 ? 16.95532  -19.28885 16.96875  1.000 30.90375  ?  301  LYS A O   1 
ATOM   2292 C  CB  . LYS A 1 301 ? 17.55423  -19.36203 13.97552  1.000 33.26517  ?  301  LYS A CB  1 
ATOM   2293 C  CG  . LYS A 1 301 ? 17.60585  -19.94787 12.56693  1.000 37.83630  ?  301  LYS A CG  1 
ATOM   2294 C  CD  . LYS A 1 301 ? 18.90122  -19.62020 11.79826  1.000 42.93914  ?  301  LYS A CD  1 
ATOM   2295 C  CE  . LYS A 1 301 ? 20.13882  -19.96532 12.63669  1.000 50.03339  ?  301  LYS A CE  1 
ATOM   2296 N  NZ  . LYS A 1 301 ? 21.45281  -19.88401 11.90775  1.000 45.09280  ?  301  LYS A NZ  1 
ATOM   2297 N  N   . ARG A 1 302 ? 15.35245  -17.93025 16.18098  1.000 36.09729  ?  302  ARG A N   1 
ATOM   2298 C  CA  . ARG A 1 302 ? 15.27412  -17.15703 17.42188  1.000 31.36864  ?  302  ARG A CA  1 
ATOM   2299 C  C   . ARG A 1 302 ? 13.95690  -16.37605 17.47483  1.000 31.59965  ?  302  ARG A C   1 
ATOM   2300 O  O   . ARG A 1 302 ? 13.19275  -16.32664 16.50459  1.000 25.64015  ?  302  ARG A O   1 
ATOM   2301 C  CB  . ARG A 1 302 ? 16.48974  -16.22632 17.58747  1.000 30.10655  ?  302  ARG A CB  1 
ATOM   2302 C  CG  . ARG A 1 302 ? 16.49143  -14.96444 16.73076  1.000 28.44900  ?  302  ARG A CG  1 
ATOM   2303 C  CD  . ARG A 1 302 ? 17.81824  -14.22257 16.77811  1.000 28.91744  ?  302  ARG A CD  1 
ATOM   2304 N  NE  . ARG A 1 302 ? 18.96971  -15.10719 16.97014  1.000 38.30448  ?  302  ARG A NE  1 
ATOM   2305 C  CZ  . ARG A 1 302 ? 19.57318  -15.77040 15.99575  1.000 30.66223  ?  302  ARG A CZ  1 
ATOM   2306 N  NH1 . ARG A 1 302 ? 19.19531  -15.63901 14.73743  1.000 28.43345  ?  302  ARG A NH1 1 
ATOM   2307 N  NH2 . ARG A 1 302 ? 20.55999  -16.61349 16.29491  1.000 39.65173  ?  302  ARG A NH2 1 
ATOM   2308 N  N   . ILE A 1 303 ? 13.69046  -15.78755 18.64809  1.000 28.74824  ?  303  ILE A N   1 
ATOM   2309 C  CA  . ILE A 1 303 ? 12.45680  -15.05476 18.92223  1.000 26.96699  ?  303  ILE A CA  1 
ATOM   2310 C  C   . ILE A 1 303 ? 12.82776  -13.63141 19.32768  1.000 29.40465  ?  303  ILE A C   1 
ATOM   2311 O  O   . ILE A 1 303 ? 13.70510  -13.43048 20.18121  1.000 28.14584  ?  303  ILE A O   1 
ATOM   2312 C  CB  . ILE A 1 303 ? 11.61277  -15.76233 20.00676  1.000 29.68330  ?  303  ILE A CB  1 
ATOM   2313 C  CG1 . ILE A 1 303 ? 11.06579  -17.10009 19.45802  1.000 31.45908  ?  303  ILE A CG1 1 
ATOM   2314 C  CG2 . ILE A 1 303 ? 10.43638  -14.90144 20.49748  1.000 24.63280  ?  303  ILE A CG2 1 
ATOM   2315 C  CD1 . ILE A 1 303 ? 10.42106  -18.00381 20.53775  1.000 30.64300  ?  303  ILE A CD1 1 
ATOM   2316 N  N   . ILE A 1 304 ? 12.19509  -12.64509 18.68841  1.000 28.39483  ?  304  ILE A N   1 
ATOM   2317 C  CA  . ILE A 1 304 ? 12.45993  -11.23443 18.98249  1.000 33.82609  ?  304  ILE A CA  1 
ATOM   2318 C  C   . ILE A 1 304 ? 11.15982  -10.55330 19.38974  1.000 29.69058  ?  304  ILE A C   1 
ATOM   2319 O  O   . ILE A 1 304 ? 10.20342  -10.50656 18.61148  1.000 27.85268  ?  304  ILE A O   1 
ATOM   2320 C  CB  . ILE A 1 304 ? 13.09705  -10.48617 17.80144  1.000 28.98808  ?  304  ILE A CB  1 
ATOM   2321 C  CG1 . ILE A 1 304 ? 14.41183  -11.13679 17.40204  1.000 25.62682  ?  304  ILE A CG1 1 
ATOM   2322 C  CG2 . ILE A 1 304 ? 13.37680  -9.04955  18.20804  1.000 25.15741  ?  304  ILE A CG2 1 
ATOM   2323 C  CD1 . ILE A 1 304 ? 14.91392  -10.74754 15.97686  1.000 24.91945  ?  304  ILE A CD1 1 
ATOM   2324 N  N   . TYR A 1 305 ? 11.15935  -9.97632  20.57899  1.000 29.80383  ?  305  TYR A N   1 
ATOM   2325 C  CA  . TYR A 1 305 ? 9.98991   -9.40272  21.21921  1.000 28.50732  ?  305  TYR A CA  1 
ATOM   2326 C  C   . TYR A 1 305 ? 10.23049  -7.88750  21.31241  1.000 28.90510  ?  305  TYR A C   1 
ATOM   2327 O  O   . TYR A 1 305 ? 11.08243  -7.43299  22.08145  1.000 28.85679  ?  305  TYR A O   1 
ATOM   2328 C  CB  . TYR A 1 305 ? 9.79789   -10.08469 22.57926  1.000 25.40448  ?  305  TYR A CB  1 
ATOM   2329 C  CG  . TYR A 1 305 ? 8.55001   -9.67833  23.29665  1.000 37.47541  ?  305  TYR A CG  1 
ATOM   2330 C  CD1 . TYR A 1 305 ? 7.32616   -10.26498 23.01009  1.000 36.98517  ?  305  TYR A CD1 1 
ATOM   2331 C  CD2 . TYR A 1 305 ? 8.59451   -8.68941  24.27508  1.000 45.00814  ?  305  TYR A CD2 1 
ATOM   2332 C  CE1 . TYR A 1 305 ? 6.16793   -9.85005  23.68072  1.000 47.67816  ?  305  TYR A CE1 1 
ATOM   2333 C  CE2 . TYR A 1 305 ? 7.46834   -8.28530  24.94678  1.000 38.17883  ?  305  TYR A CE2 1 
ATOM   2334 C  CZ  . TYR A 1 305 ? 6.26017   -8.84566  24.64838  1.000 45.01905  ?  305  TYR A CZ  1 
ATOM   2335 O  OH  . TYR A 1 305 ? 5.16310   -8.39142  25.34414  1.000 43.66957  ?  305  TYR A OH  1 
ATOM   2336 N  N   . ALA A 1 306 ? 9.53849   -7.10254  20.49163  1.000 28.15865  ?  306  ALA A N   1 
ATOM   2337 C  CA  . ALA A 1 306 ? 9.83160   -5.67112  20.39991  1.000 32.94607  ?  306  ALA A CA  1 
ATOM   2338 C  C   . ALA A 1 306 ? 8.64998   -4.86941  20.90696  1.000 35.13184  ?  306  ALA A C   1 
ATOM   2339 O  O   . ALA A 1 306 ? 7.52830   -5.05666  20.43081  1.000 35.80781  ?  306  ALA A O   1 
ATOM   2340 C  CB  . ALA A 1 306 ? 10.16856  -5.24495  18.96808  1.000 31.01056  ?  306  ALA A CB  1 
ATOM   2341 N  N   . ILE A 1 307 ? 8.90749   -3.98201  21.85852  1.000 32.30126  ?  307  ILE A N   1 
ATOM   2342 C  CA  . ILE A 1 307 ? 7.84537   -3.28625  22.58218  1.000 34.21184  ?  307  ILE A CA  1 
ATOM   2343 C  C   . ILE A 1 307 ? 7.98288   -1.79281  22.31419  1.000 34.42366  ?  307  ILE A C   1 
ATOM   2344 O  O   . ILE A 1 307 ? 9.02943   -1.32132  21.82962  1.000 33.15959  ?  307  ILE A O   1 
ATOM   2345 C  CB  . ILE A 1 307 ? 7.87275   -3.60591  24.09631  1.000 39.16328  ?  307  ILE A CB  1 
ATOM   2346 C  CG1 . ILE A 1 307 ? 8.99947   -2.86907  24.81744  1.000 40.26820  ?  307  ILE A CG1 1 
ATOM   2347 C  CG2 . ILE A 1 307 ? 7.99522   -5.08330  24.33706  1.000 37.98538  ?  307  ILE A CG2 1 
ATOM   2348 C  CD1 . ILE A 1 307 ? 9.19603   -3.38125  26.24497  1.000 42.92500  ?  307  ILE A CD1 1 
ATOM   2349 N  N   . PRO A 1 308 ? 6.93431   -1.01563  22.59768  1.000 33.10821  ?  308  PRO A N   1 
ATOM   2350 C  CA  . PRO A 1 308 ? 7.00495   0.42717   22.34387  1.000 33.28529  ?  308  PRO A CA  1 
ATOM   2351 C  C   . PRO A 1 308 ? 8.12713   1.08619   23.12177  1.000 31.61195  ?  308  PRO A C   1 
ATOM   2352 O  O   . PRO A 1 308 ? 8.48692   0.67432   24.22406  1.000 33.80091  ?  308  PRO A O   1 
ATOM   2353 C  CB  . PRO A 1 308 ? 5.63460   0.93675   22.80169  1.000 34.76083  ?  308  PRO A CB  1 
ATOM   2354 C  CG  . PRO A 1 308 ? 4.72865   -0.26910  22.63733  1.000 39.49480  ?  308  PRO A CG  1 
ATOM   2355 C  CD  . PRO A 1 308 ? 5.57083   -1.44774  22.97482  1.000 33.75596  ?  308  PRO A CD  1 
ATOM   2356 N  N   . PHE A 1 309 ? 8.67484   2.13588   22.52228  1.000 36.21450  ?  309  PHE A N   1 
ATOM   2357 C  CA  . PHE A 1 309 ? 9.78071   2.86484   23.12842  1.000 36.17708  ?  309  PHE A CA  1 
ATOM   2358 C  C   . PHE A 1 309 ? 9.43289   3.39059   24.51937  1.000 35.16046  ?  309  PHE A C   1 
ATOM   2359 O  O   . PHE A 1 309 ? 10.30026  3.47354   25.38518  1.000 35.77304  ?  309  PHE A O   1 
ATOM   2360 C  CB  . PHE A 1 309 ? 10.19271  4.00828   22.20647  1.000 41.65535  ?  309  PHE A CB  1 
ATOM   2361 C  CG  . PHE A 1 309 ? 11.29138  4.86798   22.76457  1.000 52.53132  ?  309  PHE A CG  1 
ATOM   2362 C  CD1 . PHE A 1 309 ? 10.99658  6.07585   23.39709  1.000 49.89749  ?  309  PHE A CD1 1 
ATOM   2363 C  CD2 . PHE A 1 309 ? 12.62380  4.47494   22.65776  1.000 50.60303  ?  309  PHE A CD2 1 
ATOM   2364 C  CE1 . PHE A 1 309 ? 12.01702  6.86661   23.91744  1.000 52.15570  ?  309  PHE A CE1 1 
ATOM   2365 C  CE2 . PHE A 1 309 ? 13.64496  5.26034   23.17675  1.000 52.65781  ?  309  PHE A CE2 1 
ATOM   2366 C  CZ  . PHE A 1 309 ? 13.34237  6.45379   23.80923  1.000 54.74162  ?  309  PHE A CZ  1 
ATOM   2367 N  N   . THR A 1 310 ? 8.17976   3.73271   24.76690  1.000 41.42775  ?  310  THR A N   1 
ATOM   2368 C  CA  . THR A 1 310 ? 7.79884   4.31391   26.05497  1.000 41.19766  ?  310  THR A CA  1 
ATOM   2369 C  C   . THR A 1 310 ? 7.43618   3.22275   27.06164  1.000 41.53207  ?  310  THR A C   1 
ATOM   2370 O  O   . THR A 1 310 ? 6.34511   3.19795   27.62319  1.000 45.06825  ?  310  THR A O   1 
ATOM   2371 C  CB  . THR A 1 310 ? 6.64382   5.29060   25.86269  1.000 45.83432  ?  310  THR A CB  1 
ATOM   2372 O  OG1 . THR A 1 310 ? 5.62650   4.66256   25.05976  1.000 46.74505  ?  310  THR A OG1 1 
ATOM   2373 C  CG2 . THR A 1 310 ? 7.13136   6.56246   25.16495  1.000 43.50931  ?  310  THR A CG2 1 
ATOM   2374 N  N   . SER A 1 311 ? 8.40430   2.34693   27.32112  1.000 45.94572  ?  311  SER A N   1 
ATOM   2375 C  CA  . SER A 1 311 ? 8.18745   1.14180   28.10394  1.000 40.76578  ?  311  SER A CA  1 
ATOM   2376 C  C   . SER A 1 311 ? 9.34935   0.92778   29.05344  1.000 47.74199  ?  311  SER A C   1 
ATOM   2377 O  O   . SER A 1 311 ? 10.43993  1.47005   28.85864  1.000 48.34548  ?  311  SER A O   1 
ATOM   2378 C  CB  . SER A 1 311 ? 8.10707   -0.08784  27.21876  1.000 46.88077  ?  311  SER A CB  1 
ATOM   2379 O  OG  . SER A 1 311 ? 6.81746   -0.20345  26.68415  1.000 57.75929  ?  311  SER A OG  1 
ATOM   2380 N  N   . ILE A 1 312 ? 9.11465   0.10119   30.06984  1.000 41.10452  ?  312  ILE A N   1 
ATOM   2381 C  CA  . ILE A 1 312 ? 10.18440  -0.44756  30.88895  1.000 36.76203  ?  312  ILE A CA  1 
ATOM   2382 C  C   . ILE A 1 312 ? 10.42038  -1.85517  30.37232  1.000 40.61193  ?  312  ILE A C   1 
ATOM   2383 O  O   . ILE A 1 312 ? 9.61668   -2.76627  30.60434  1.000 43.68181  ?  312  ILE A O   1 
ATOM   2384 C  CB  . ILE A 1 312 ? 9.84330   -0.43269  32.38417  1.000 35.99245  ?  312  ILE A CB  1 
ATOM   2385 C  CG1 . ILE A 1 312 ? 9.26609   0.92623   32.78244  1.000 46.08852  ?  312  ILE A CG1 1 
ATOM   2386 C  CG2 . ILE A 1 312 ? 11.10672  -0.69932  33.21940  1.000 36.19491  ?  312  ILE A CG2 1 
ATOM   2387 C  CD1 . ILE A 1 312 ? 8.85782   1.00900   34.23853  1.000 42.00970  ?  312  ILE A CD1 1 
ATOM   2388 N  N   . ILE A 1 313 ? 11.52031  -2.00661  29.65002  1.000 38.50605  ?  313  ILE A N   1 
ATOM   2389 C  CA  . ILE A 1 313 ? 11.86910  -3.26857  29.02657  1.000 40.47908  ?  313  ILE A CA  1 
ATOM   2390 C  C   . ILE A 1 313 ? 11.99210  -4.36449  30.07210  1.000 40.63768  ?  313  ILE A C   1 
ATOM   2391 O  O   . ILE A 1 313 ? 11.48504  -5.47703  29.88633  1.000 39.29081  ?  313  ILE A O   1 
ATOM   2392 C  CB  . ILE A 1 313 ? 13.16656  -3.07745  28.22540  1.000 42.74006  ?  313  ILE A CB  1 
ATOM   2393 C  CG1 . ILE A 1 313 ? 12.84585  -2.50615  26.84630  1.000 45.34723  ?  313  ILE A CG1 1 
ATOM   2394 C  CG2 . ILE A 1 313 ? 13.91017  -4.35659  28.10136  1.000 43.80934  ?  313  ILE A CG2 1 
ATOM   2395 C  CD1 . ILE A 1 313 ? 12.87170  -3.55250  25.77192  1.000 43.58445  ?  313  ILE A CD1 1 
ATOM   2396 N  N   . GLU A 1 314 ? 12.65430  -4.05076  31.19104  1.000 39.85171  ?  314  GLU A N   1 
ATOM   2397 C  CA  . GLU A 1 314 ? 12.89923  -4.98716  32.29015  1.000 42.02173  ?  314  GLU A CA  1 
ATOM   2398 C  C   . GLU A 1 314 ? 11.63832  -5.70944  32.75582  1.000 39.02911  ?  314  GLU A C   1 
ATOM   2399 O  O   . GLU A 1 314 ? 11.65231  -6.92459  33.02876  1.000 38.90891  ?  314  GLU A O   1 
ATOM   2400 C  CB  . GLU A 1 314 ? 13.46978  -4.19754  33.46697  1.000 45.19752  ?  314  GLU A CB  1 
ATOM   2401 C  CG  . GLU A 1 314 ? 14.35292  -4.97267  34.35471  1.000 46.54515  ?  314  GLU A CG  1 
ATOM   2402 C  CD  . GLU A 1 314 ? 15.33628  -4.09026  35.07075  1.000 46.62139  ?  314  GLU A CD  1 
ATOM   2403 O  OE1 . GLU A 1 314 ? 14.93015  -3.41638  36.05646  1.000 43.27498  ?  314  GLU A OE1 1 
ATOM   2404 O  OE2 . GLU A 1 314 ? 16.51504  -4.09427  34.63797  1.000 46.01254  -1 314  GLU A OE2 1 
ATOM   2405 N  N   . GLN A 1 315 ? 10.55270  -4.94419  32.91112  1.000 34.82906  ?  315  GLN A N   1 
ATOM   2406 C  CA  . GLN A 1 315 ? 9.28384   -5.45738  33.40846  1.000 35.83031  ?  315  GLN A CA  1 
ATOM   2407 C  C   . GLN A 1 315 ? 8.66543   -6.46496  32.44937  1.000 40.37368  ?  315  GLN A C   1 
ATOM   2408 O  O   . GLN A 1 315 ? 8.03954   -7.43874  32.88553  1.000 41.15626  ?  315  GLN A O   1 
ATOM   2409 C  CB  . GLN A 1 315 ? 8.34681   -4.28136  33.65760  1.000 38.06692  ?  315  GLN A CB  1 
ATOM   2410 C  CG  . GLN A 1 315 ? 8.87321   -3.34815  34.74677  1.000 39.14383  ?  315  GLN A CG  1 
ATOM   2411 C  CD  . GLN A 1 315 ? 8.68815   -3.96859  36.13403  1.000 41.00166  ?  315  GLN A CD  1 
ATOM   2412 O  OE1 . GLN A 1 315 ? 7.66105   -4.57789  36.41212  1.000 40.12978  ?  315  GLN A OE1 1 
ATOM   2413 N  NE2 . GLN A 1 315 ? 9.68104   -3.81759  36.99653  1.000 40.05867  ?  315  GLN A NE2 1 
ATOM   2414 N  N   . ASN A 1 316 ? 8.83477   -6.25412  31.14296  1.000 36.98638  ?  316  ASN A N   1 
ATOM   2415 C  CA  . ASN A 1 316 ? 8.41041   -7.25929  30.17542  1.000 36.80950  ?  316  ASN A CA  1 
ATOM   2416 C  C   . ASN A 1 316 ? 9.36455   -8.43764  30.15016  1.000 40.63188  ?  316  ASN A C   1 
ATOM   2417 O  O   . ASN A 1 316 ? 8.93189   -9.59391  30.07533  1.000 41.31049  ?  316  ASN A O   1 
ATOM   2418 C  CB  . ASN A 1 316 ? 8.30642   -6.63363  28.79049  1.000 43.30995  ?  316  ASN A CB  1 
ATOM   2419 C  CG  . ASN A 1 316 ? 7.24680   -5.55534  28.73623  1.000 45.73326  ?  316  ASN A CG  1 
ATOM   2420 O  OD1 . ASN A 1 316 ? 7.40395   -4.47387  29.31975  1.000 44.51353  ?  316  ASN A OD1 1 
ATOM   2421 N  ND2 . ASN A 1 316 ? 6.14336   -5.85314  28.06026  1.000 41.69925  ?  316  ASN A ND2 1 
ATOM   2422 N  N   . ALA A 1 317 ? 10.66459  -8.17296  30.22627  1.000 37.39457  ?  317  ALA A N   1 
ATOM   2423 C  CA  . ALA A 1 317 ? 11.63682  -9.25723  30.12539  1.000 38.87862  ?  317  ALA A CA  1 
ATOM   2424 C  C   . ALA A 1 317 ? 11.54007  -10.23421 31.29192  1.000 44.37546  ?  317  ALA A C   1 
ATOM   2425 O  O   . ALA A 1 317 ? 11.92648  -11.39925 31.14576  1.000 40.97460  ?  317  ALA A O   1 
ATOM   2426 C  CB  . ALA A 1 317 ? 13.05802  -8.69916  30.03670  1.000 38.33763  ?  317  ALA A CB  1 
ATOM   2427 N  N   . ASN A 1 318 ? 11.05592  -9.78432  32.45814  1.000 44.44902  ?  318  ASN A N   1 
ATOM   2428 C  CA  . ASN A 1 318 ? 10.99850  -10.69287 33.60848  1.000 44.04211  ?  318  ASN A CA  1 
ATOM   2429 C  C   . ASN A 1 318 ? 10.07041  -11.87425 33.36106  1.000 43.26518  ?  318  ASN A C   1 
ATOM   2430 O  O   . ASN A 1 318 ? 10.32025  -12.96580 33.87362  1.000 51.02577  ?  318  ASN A O   1 
ATOM   2431 C  CB  . ASN A 1 318 ? 10.56548  -9.94433  34.87125  1.000 40.26622  ?  318  ASN A CB  1 
ATOM   2432 C  CG  . ASN A 1 318 ? 11.67543  -9.07128  35.43714  1.000 40.41053  ?  318  ASN A CG  1 
ATOM   2433 O  OD1 . ASN A 1 318 ? 12.83623  -9.18961  35.04385  1.000 40.30344  ?  318  ASN A OD1 1 
ATOM   2434 N  ND2 . ASN A 1 318 ? 11.31454  -8.16093  36.32921  1.000 44.05841  ?  318  ASN A ND2 1 
ATOM   2435 N  N   . VAL A 1 319 ? 8.98380   -11.67819 32.61298  1.000 43.81573  ?  319  VAL A N   1 
ATOM   2436 C  CA  . VAL A 1 319 ? 8.11107   -12.79853 32.25098  1.000 44.09273  ?  319  VAL A CA  1 
ATOM   2437 C  C   . VAL A 1 319 ? 8.93348   -13.88703 31.56657  1.000 48.95614  ?  319  VAL A C   1 
ATOM   2438 O  O   . VAL A 1 319 ? 8.86542   -15.06573 31.92415  1.000 47.58397  ?  319  VAL A O   1 
ATOM   2439 C  CB  . VAL A 1 319 ? 6.96386   -12.30775 31.34438  1.000 43.61563  ?  319  VAL A CB  1 
ATOM   2440 C  CG1 . VAL A 1 319 ? 5.99796   -13.42999 31.03068  1.000 45.63743  ?  319  VAL A CG1 1 
ATOM   2441 C  CG2 . VAL A 1 319 ? 6.22494   -11.11683 31.97903  1.000 45.79970  ?  319  VAL A CG2 1 
ATOM   2442 N  N   . PHE A 1 320 ? 9.76157   -13.48809 30.59462  1.000 49.59329  ?  320  PHE A N   1 
ATOM   2443 C  CA  . PHE A 1 320 ? 10.59676  -14.44649 29.87798  1.000 46.94198  ?  320  PHE A CA  1 
ATOM   2444 C  C   . PHE A 1 320 ? 11.66239  -15.05293 30.78614  1.000 53.76134  ?  320  PHE A C   1 
ATOM   2445 O  O   . PHE A 1 320 ? 11.98254  -16.24296 30.66666  1.000 52.90015  ?  320  PHE A O   1 
ATOM   2446 C  CB  . PHE A 1 320 ? 11.24311  -13.77506 28.66762  1.000 44.49184  ?  320  PHE A CB  1 
ATOM   2447 C  CG  . PHE A 1 320 ? 10.26121  -13.30518 27.63303  1.000 42.34427  ?  320  PHE A CG  1 
ATOM   2448 C  CD1 . PHE A 1 320 ? 9.66330   -14.20100 26.77409  1.000 40.10143  ?  320  PHE A CD1 1 
ATOM   2449 C  CD2 . PHE A 1 320 ? 9.94341   -11.96666 27.51852  1.000 44.32991  ?  320  PHE A CD2 1 
ATOM   2450 C  CE1 . PHE A 1 320 ? 8.75962   -13.77320 25.81068  1.000 43.82111  ?  320  PHE A CE1 1 
ATOM   2451 C  CE2 . PHE A 1 320 ? 9.04178   -11.52013 26.55804  1.000 41.39274  ?  320  PHE A CE2 1 
ATOM   2452 C  CZ  . PHE A 1 320 ? 8.44781   -12.42698 25.70176  1.000 40.08387  ?  320  PHE A CZ  1 
ATOM   2453 N  N   . ARG A 1 321 ? 12.24544  -14.24732 31.67878  1.000 51.54032  ?  321  ARG A N   1 
ATOM   2454 C  CA  . ARG A 1 321 ? 13.23744  -14.78270 32.60724  1.000 54.21977  ?  321  ARG A CA  1 
ATOM   2455 C  C   . ARG A 1 321 ? 12.63337  -15.84743 33.51192  1.000 49.66296  ?  321  ARG A C   1 
ATOM   2456 O  O   . ARG A 1 321 ? 13.24576  -16.89273 33.74160  1.000 52.84154  ?  321  ARG A O   1 
ATOM   2457 C  CB  . ARG A 1 321 ? 13.83800  -13.67213 33.45266  1.000 49.83568  ?  321  ARG A CB  1 
ATOM   2458 C  CG  . ARG A 1 321 ? 14.98502  -12.96892 32.80228  1.000 51.06764  ?  321  ARG A CG  1 
ATOM   2459 C  CD  . ARG A 1 321 ? 15.19192  -11.66955 33.49745  1.000 46.97763  ?  321  ARG A CD  1 
ATOM   2460 N  NE  . ARG A 1 321 ? 15.81932  -10.69782 32.61597  1.000 57.27859  ?  321  ARG A NE  1 
ATOM   2461 C  CZ  . ARG A 1 321 ? 15.52784  -9.40595  32.62019  1.000 53.85920  ?  321  ARG A CZ  1 
ATOM   2462 N  NH1 . ARG A 1 321 ? 14.60173  -8.91521  33.43212  1.000 40.01955  ?  321  ARG A NH1 1 
ATOM   2463 N  NH2 . ARG A 1 321 ? 16.16697  -8.59360  31.77605  1.000 56.08124  ?  321  ARG A NH2 1 
ATOM   2464 N  N   . ASN A 1 322 ? 11.44030  -15.58198 34.05514  1.000 50.22232  ?  322  ASN A N   1 
ATOM   2465 C  CA  . ASN A 1 322 ? 10.76703  -16.55674 34.91336  1.000 51.82802  ?  322  ASN A CA  1 
ATOM   2466 C  C   . ASN A 1 322 ? 10.39098  -17.81036 34.13414  1.000 59.90624  ?  322  ASN A C   1 
ATOM   2467 O  O   . ASN A 1 322 ? 10.57699  -18.93106 34.62173  1.000 64.57206  ?  322  ASN A O   1 
ATOM   2468 C  CB  . ASN A 1 322 ? 9.50842   -15.95762 35.54492  1.000 54.07981  ?  322  ASN A CB  1 
ATOM   2469 C  CG  . ASN A 1 322 ? 9.78936   -14.73404 36.42774  1.000 52.52034  ?  322  ASN A CG  1 
ATOM   2470 O  OD1 . ASN A 1 322 ? 10.90972  -14.50681 36.87738  1.000 53.71965  ?  322  ASN A OD1 1 
ATOM   2471 N  ND2 . ASN A 1 322 ? 8.75031   -13.95540 36.68794  1.000 47.31763  ?  322  ASN A ND2 1 
ATOM   2472 N  N   . ALA A 1 323 ? 9.86268   -17.64317 32.91517  1.000 57.95817  ?  323  ALA A N   1 
ATOM   2473 C  CA  . ALA A 1 323 ? 9.44017   -18.79762 32.12992  1.000 56.70674  ?  323  ALA A CA  1 
ATOM   2474 C  C   . ALA A 1 323 ? 10.62618  -19.65523 31.69252  1.000 58.20625  ?  323  ALA A C   1 
ATOM   2475 O  O   . ALA A 1 323 ? 10.52110  -20.88627 31.65047  1.000 60.14362  ?  323  ALA A O   1 
ATOM   2476 C  CB  . ALA A 1 323 ? 8.63752   -18.33821 30.91015  1.000 53.19324  ?  323  ALA A CB  1 
ATOM   2477 N  N   . LEU A 1 324 ? 11.75914  -19.03323 31.35352  1.000 56.23515  ?  324  LEU A N   1 
ATOM   2478 C  CA  . LEU A 1 324 ? 12.81026  -19.73077 30.62750  1.000 60.56027  ?  324  LEU A CA  1 
ATOM   2479 C  C   . LEU A 1 324 ? 14.22023  -19.60359 31.20087  1.000 66.16571  ?  324  LEU A C   1 
ATOM   2480 O  O   . LEU A 1 324 ? 15.16736  -20.07082 30.55121  1.000 62.39607  ?  324  LEU A O   1 
ATOM   2481 C  CB  . LEU A 1 324 ? 12.84571  -19.25287 29.17020  1.000 58.64204  ?  324  LEU A CB  1 
ATOM   2482 C  CG  . LEU A 1 324 ? 11.53345  -19.18888 28.40344  1.000 54.07387  ?  324  LEU A CG  1 
ATOM   2483 C  CD1 . LEU A 1 324 ? 11.77678  -18.37919 27.17733  1.000 46.20346  ?  324  LEU A CD1 1 
ATOM   2484 C  CD2 . LEU A 1 324 ? 11.03539  -20.57966 28.01522  1.000 51.45797  ?  324  LEU A CD2 1 
ATOM   2485 N  N   . GLY A 1 325 ? 14.40130  -18.97653 32.36565  1.000 65.04940  ?  325  GLY A N   1 
ATOM   2486 C  CA  . GLY A 1 325 ? 15.69898  -18.93091 33.01306  1.000 67.12354  ?  325  GLY A CA  1 
ATOM   2487 C  C   . GLY A 1 325 ? 16.59558  -17.80053 32.52479  1.000 69.42399  ?  325  GLY A C   1 
ATOM   2488 O  O   . GLY A 1 325 ? 16.36270  -17.16306 31.49375  1.000 68.11162  ?  325  GLY A O   1 
ATOM   2489 N  N   . ASP A 1 326 ? 17.66821  -17.56797 33.28768  1.000 70.62035  ?  326  ASP A N   1 
ATOM   2490 C  CA  . ASP A 1 326 ? 18.49555  -16.38035 33.07074  1.000 74.96936  ?  326  ASP A CA  1 
ATOM   2491 C  C   . ASP A 1 326 ? 19.24220  -16.43794 31.74231  1.000 73.86101  ?  326  ASP A C   1 
ATOM   2492 O  O   . ASP A 1 326 ? 19.17462  -15.50180 30.93754  1.000 72.28772  ?  326  ASP A O   1 
ATOM   2493 C  CB  . ASP A 1 326 ? 19.48476  -16.21236 34.22334  1.000 76.05768  ?  326  ASP A CB  1 
ATOM   2494 C  CG  . ASP A 1 326 ? 19.46824  -14.81131 34.80235  1.000 82.93205  ?  326  ASP A CG  1 
ATOM   2495 O  OD1 . ASP A 1 326 ? 20.43240  -14.44686 35.52093  1.000 84.81753  -1 326  ASP A OD1 1 
ATOM   2496 O  OD2 . ASP A 1 326 ? 18.48724  -14.07791 34.53535  1.000 78.71622  -1 326  ASP A OD2 1 
ATOM   2497 N  N   . ASP A 1 327 ? 19.93164  -17.54135 31.48269  1.000 70.89375  ?  327  ASP A N   1 
ATOM   2498 C  CA  . ASP A 1 327 ? 20.93364  -17.61828 30.42427  1.000 70.92060  ?  327  ASP A CA  1 
ATOM   2499 C  C   . ASP A 1 327 ? 20.38634  -17.44485 29.00201  1.000 69.43929  ?  327  ASP A C   1 
ATOM   2500 O  O   . ASP A 1 327 ? 21.16206  -17.39974 28.04179  1.000 71.42982  ?  327  ASP A O   1 
ATOM   2501 C  CB  . ASP A 1 327 ? 21.67404  -18.96052 30.57009  1.000 74.60902  ?  327  ASP A CB  1 
ATOM   2502 C  CG  . ASP A 1 327 ? 22.65759  -19.24378 29.43425  1.000 79.74198  ?  327  ASP A CG  1 
ATOM   2503 O  OD1 . ASP A 1 327 ? 23.31315  -18.30081 28.93149  1.000 83.50406  -1 327  ASP A OD1 1 
ATOM   2504 O  OD2 . ASP A 1 327 ? 22.78191  -20.42749 29.04713  1.000 85.33178  -1 327  ASP A OD2 1 
ATOM   2505 N  N   . VAL A 1 328 ? 19.07070  -17.31136 28.82604  1.000 69.70091  ?  328  VAL A N   1 
ATOM   2506 C  CA  . VAL A 1 328 ? 18.51930  -17.34139 27.46810  1.000 59.85876  ?  328  VAL A CA  1 
ATOM   2507 C  C   . VAL A 1 328 ? 18.12906  -15.95651 26.95806  1.000 48.29498  ?  328  VAL A C   1 
ATOM   2508 O  O   . VAL A 1 328 ? 18.20548  -15.68797 25.74745  1.000 44.21813  ?  328  VAL A O   1 
ATOM   2509 C  CB  . VAL A 1 328 ? 17.31833  -18.29880 27.40066  1.000 57.62482  ?  328  VAL A CB  1 
ATOM   2510 C  CG1 . VAL A 1 328 ? 17.74718  -19.66939 27.87456  1.000 66.26096  ?  328  VAL A CG1 1 
ATOM   2511 C  CG2 . VAL A 1 328 ? 16.18221  -17.79489 28.25805  1.000 60.09894  ?  328  VAL A CG2 1 
ATOM   2512 N  N   . VAL A 1 329 ? 17.71458  -15.07449 27.86729  1.000 46.00535  ?  329  VAL A N   1 
ATOM   2513 C  CA  . VAL A 1 329 ? 17.07836  -13.80766 27.50407  1.000 43.79684  ?  329  VAL A CA  1 
ATOM   2514 C  C   . VAL A 1 329 ? 18.14899  -12.73457 27.36006  1.000 43.35917  ?  329  VAL A C   1 
ATOM   2515 O  O   . VAL A 1 329 ? 18.91287  -12.47447 28.29270  1.000 43.79114  ?  329  VAL A O   1 
ATOM   2516 C  CB  . VAL A 1 329 ? 16.03005  -13.38801 28.55009  1.000 45.48137  ?  329  VAL A CB  1 
ATOM   2517 C  CG1 . VAL A 1 329 ? 15.42838  -12.04342 28.18278  1.000 41.93003  ?  329  VAL A CG1 1 
ATOM   2518 C  CG2 . VAL A 1 329 ? 14.93204  -14.42640 28.66926  1.000 47.55958  ?  329  VAL A CG2 1 
ATOM   2519 N  N   . LEU A 1 330 ? 18.19501  -12.08729 26.20786  1.000 41.54046  ?  330  LEU A N   1 
ATOM   2520 C  CA  . LEU A 1 330 ? 19.05272  -10.93226 26.01414  1.000 37.54425  ?  330  LEU A CA  1 
ATOM   2521 C  C   . LEU A 1 330 ? 18.18068  -9.68528  25.94956  1.000 38.52284  ?  330  LEU A C   1 
ATOM   2522 O  O   . LEU A 1 330 ? 17.25779  -9.60529  25.13238  1.000 36.51035  ?  330  LEU A O   1 
ATOM   2523 C  CB  . LEU A 1 330 ? 19.88889  -11.07438 24.74287  1.000 34.61803  ?  330  LEU A CB  1 
ATOM   2524 C  CG  . LEU A 1 330 ? 20.55897  -9.77142  24.31695  1.000 37.17724  ?  330  LEU A CG  1 
ATOM   2525 C  CD1 . LEU A 1 330 ? 21.48649  -9.26880  25.39094  1.000 41.45964  ?  330  LEU A CD1 1 
ATOM   2526 C  CD2 . LEU A 1 330 ? 21.33350  -10.00870 23.04625  1.000 40.02058  ?  330  LEU A CD2 1 
ATOM   2527 N  N   . GLU A 1 331 ? 18.49127  -8.71836  26.80167  1.000 35.61032  ?  331  GLU A N   1 
ATOM   2528 C  CA  . GLU A 1 331 ? 17.74310  -7.48501  26.95679  1.000 36.67163  ?  331  GLU A CA  1 
ATOM   2529 C  C   . GLU A 1 331 ? 18.55110  -6.35119  26.34123  1.000 40.83988  ?  331  GLU A C   1 
ATOM   2530 O  O   . GLU A 1 331 ? 19.64383  -6.04422  26.82045  1.000 41.48914  ?  331  GLU A O   1 
ATOM   2531 C  CB  . GLU A 1 331 ? 17.51192  -7.22805  28.44029  1.000 40.10952  ?  331  GLU A CB  1 
ATOM   2532 C  CG  . GLU A 1 331 ? 16.41303  -6.30955  28.77324  1.000 40.31800  ?  331  GLU A CG  1 
ATOM   2533 C  CD  . GLU A 1 331 ? 16.50174  -5.79775  30.22213  1.000 56.92421  ?  331  GLU A CD  1 
ATOM   2534 O  OE1 . GLU A 1 331 ? 16.96618  -4.64059  30.43736  1.000 56.70106  ?  331  GLU A OE1 1 
ATOM   2535 O  OE2 . GLU A 1 331 ? 16.13483  -6.56955  31.14711  1.000 53.08690  -1 331  GLU A OE2 1 
ATOM   2536 N  N   . HIS A 1 332 ? 18.01039  -5.71128  25.30440  1.000 43.25053  ?  332  HIS A N   1 
ATOM   2537 C  CA  . HIS A 1 332 ? 18.74466  -4.67227  24.57037  1.000 42.72142  ?  332  HIS A CA  1 
ATOM   2538 C  C   . HIS A 1 332 ? 17.77506  -3.58672  24.11989  1.000 45.19971  ?  332  HIS A C   1 
ATOM   2539 O  O   . HIS A 1 332 ? 17.04731  -3.79542  23.14876  1.000 47.86851  ?  332  HIS A O   1 
ATOM   2540 C  CB  . HIS A 1 332 ? 19.45644  -5.26411  23.35677  1.000 40.47807  ?  332  HIS A CB  1 
ATOM   2541 C  CG  . HIS A 1 332 ? 20.33412  -4.28988  22.63296  1.000 46.66025  ?  332  HIS A CG  1 
ATOM   2542 N  ND1 . HIS A 1 332 ? 20.50947  -4.31826  21.26432  1.000 39.82258  ?  332  HIS A ND1 1 
ATOM   2543 C  CD2 . HIS A 1 332 ? 21.10060  -3.26868  23.09034  1.000 48.50935  ?  332  HIS A CD2 1 
ATOM   2544 C  CE1 . HIS A 1 332 ? 21.34296  -3.35586  20.91058  1.000 39.56928  ?  332  HIS A CE1 1 
ATOM   2545 N  NE2 . HIS A 1 332 ? 21.71410  -2.70337  21.99932  1.000 48.69297  ?  332  HIS A NE2 1 
ATOM   2546 N  N   . HIS A 1 333 ? 17.78063  -2.42596  24.77863  1.000 46.13266  ?  333  HIS A N   1 
ATOM   2547 C  CA  . HIS A 1 333 ? 17.02498  -1.29207  24.25122  1.000 47.64195  ?  333  HIS A CA  1 
ATOM   2548 C  C   . HIS A 1 333 ? 17.91099  -0.13134  23.80954  1.000 51.25748  ?  333  HIS A C   1 
ATOM   2549 O  O   . HIS A 1 333 ? 17.87345  0.26105   22.63575  1.000 49.75083  ?  333  HIS A O   1 
ATOM   2550 C  CB  . HIS A 1 333 ? 15.97218  -0.79024  25.25956  1.000 48.85536  ?  333  HIS A CB  1 
ATOM   2551 C  CG  . HIS A 1 333 ? 16.45859  -0.67853  26.67354  1.000 53.59031  ?  333  HIS A CG  1 
ATOM   2552 N  ND1 . HIS A 1 333 ? 16.85355  0.52051   27.23358  1.000 53.48764  ?  333  HIS A ND1 1 
ATOM   2553 C  CD2 . HIS A 1 333 ? 16.56069  -1.60541  27.65832  1.000 50.17455  ?  333  HIS A CD2 1 
ATOM   2554 C  CE1 . HIS A 1 333 ? 17.20676  0.32139   28.49249  1.000 51.14690  ?  333  HIS A CE1 1 
ATOM   2555 N  NE2 . HIS A 1 333 ? 17.03421  -0.95951  28.77613  1.000 53.33354  ?  333  HIS A NE2 1 
ATOM   2556 N  N   . SER A 1 334 ? 18.71894  0.42744   24.70024  1.000 46.40419  ?  334  SER A N   1 
ATOM   2557 C  CA  . SER A 1 334 ? 19.29018  1.72865   24.40028  1.000 51.28165  ?  334  SER A CA  1 
ATOM   2558 C  C   . SER A 1 334 ? 20.62232  1.59482   23.66841  1.000 55.16771  ?  334  SER A C   1 
ATOM   2559 O  O   . SER A 1 334 ? 21.24690  0.52679   23.63086  1.000 54.19442  ?  334  SER A O   1 
ATOM   2560 C  CB  . SER A 1 334 ? 19.46435  2.54379   25.67760  1.000 53.01861  ?  334  SER A CB  1 
ATOM   2561 O  OG  . SER A 1 334 ? 20.78153  2.40623   26.16499  1.000 57.83442  ?  334  SER A OG  1 
ATOM   2562 N  N   . ASN A 1 335 ? 21.05768  2.70336   23.07875  1.000 55.85513  ?  335  ASN A N   1 
ATOM   2563 C  CA  . ASN A 1 335 ? 22.33193  2.73981   22.37161  1.000 56.43882  ?  335  ASN A CA  1 
ATOM   2564 C  C   . ASN A 1 335 ? 23.39428  3.28811   23.30816  1.000 56.87681  ?  335  ASN A C   1 
ATOM   2565 O  O   . ASN A 1 335 ? 23.46662  4.49272   23.55546  1.000 62.57220  ?  335  ASN A O   1 
ATOM   2566 C  CB  . ASN A 1 335 ? 22.22725  3.55502   21.09351  1.000 56.88720  ?  335  ASN A CB  1 
ATOM   2567 C  CG  . ASN A 1 335 ? 21.41537  2.84505   20.02955  1.000 58.06607  ?  335  ASN A CG  1 
ATOM   2568 O  OD1 . ASN A 1 335 ? 21.66642  1.66524   19.71979  1.000 53.63034  ?  335  ASN A OD1 1 
ATOM   2569 N  ND2 . ASN A 1 335 ? 20.43860  3.55361   19.45499  1.000 51.92482  ?  335  ASN A ND2 1 
ATOM   2570 N  N   . LEU A 1 336 ? 24.22027  2.38790   23.82990  1.000 56.58151  ?  336  LEU A N   1 
ATOM   2571 C  CA  . LEU A 1 336 ? 25.39311  2.76300   24.59950  1.000 55.58859  ?  336  LEU A CA  1 
ATOM   2572 C  C   . LEU A 1 336 ? 26.57676  2.68808   23.64738  1.000 58.27243  ?  336  LEU A C   1 
ATOM   2573 O  O   . LEU A 1 336 ? 27.28017  1.68069   23.55074  1.000 62.24352  ?  336  LEU A O   1 
ATOM   2574 C  CB  . LEU A 1 336 ? 25.57785  1.84979   25.80515  1.000 59.66434  ?  336  LEU A CB  1 
ATOM   2575 C  CG  . LEU A 1 336 ? 24.54711  2.05100   26.90247  1.000 57.80862  ?  336  LEU A CG  1 
ATOM   2576 C  CD1 . LEU A 1 336 ? 24.90932  1.18180   28.11363  1.000 55.10248  ?  336  LEU A CD1 1 
ATOM   2577 C  CD2 . LEU A 1 336 ? 24.46311  3.52342   27.26356  1.000 56.38241  ?  336  LEU A CD2 1 
ATOM   2578 N  N   . GLU A 1 337 ? 26.78570  3.77464   22.92091  1.000 57.03187  ?  337  GLU A N   1 
ATOM   2579 C  CA  . GLU A 1 337 ? 27.88654  3.86601   21.97719  1.000 52.79951  ?  337  GLU A CA  1 
ATOM   2580 C  C   . GLU A 1 337 ? 28.91701  4.83021   22.53795  1.000 45.27618  ?  337  GLU A C   1 
ATOM   2581 O  O   . GLU A 1 337 ? 28.55632  5.85535   23.11929  1.000 46.85562  ?  337  GLU A O   1 
ATOM   2582 C  CB  . GLU A 1 337 ? 27.37849  4.31742   20.60044  1.000 53.43569  ?  337  GLU A CB  1 
ATOM   2583 C  CG  . GLU A 1 337 ? 26.00574  3.71048   20.23296  1.000 61.02689  ?  337  GLU A CG  1 
ATOM   2584 C  CD  . GLU A 1 337 ? 25.83344  3.42816   18.73432  1.000 64.49752  ?  337  GLU A CD  1 
ATOM   2585 O  OE1 . GLU A 1 337 ? 25.49743  4.36696   17.97603  1.000 67.30525  ?  337  GLU A OE1 1 
ATOM   2586 O  OE2 . GLU A 1 337 ? 26.01377  2.26353   18.31820  1.000 55.96332  -1 337  GLU A OE2 1 
ATOM   2587 N  N   . VAL A 1 338 ? 30.19686  4.47970   22.41904  1.000 41.91058  ?  338  VAL A N   1 
ATOM   2588 C  CA  . VAL A 1 338 ? 31.22794  5.42567   22.82140  1.000 43.36302  ?  338  VAL A CA  1 
ATOM   2589 C  C   . VAL A 1 338 ? 31.26605  6.54098   21.78402  1.000 47.77798  ?  338  VAL A C   1 
ATOM   2590 O  O   . VAL A 1 338 ? 30.92676  6.33635   20.61084  1.000 45.74794  ?  338  VAL A O   1 
ATOM   2591 C  CB  . VAL A 1 338 ? 32.60868  4.75020   22.99141  1.000 47.59782  ?  338  VAL A CB  1 
ATOM   2592 C  CG1 . VAL A 1 338 ? 32.49202  3.41985   23.77026  1.000 44.01625  ?  338  VAL A CG1 1 
ATOM   2593 C  CG2 . VAL A 1 338 ? 33.29451  4.52913   21.66447  1.000 47.45716  ?  338  VAL A CG2 1 
ATOM   2594 N  N   . LYS A 1 339 ? 31.63830  7.74606   22.20884  1.000 46.19566  ?  339  LYS A N   1 
ATOM   2595 C  CA  . LYS A 1 339 ? 31.79351  8.80204   21.21238  1.000 54.50039  ?  339  LYS A CA  1 
ATOM   2596 C  C   . LYS A 1 339 ? 32.89804  8.40859   20.23504  1.000 58.22084  ?  339  LYS A C   1 
ATOM   2597 O  O   . LYS A 1 339 ? 33.79290  7.62437   20.56669  1.000 59.57253  ?  339  LYS A O   1 
ATOM   2598 C  CB  . LYS A 1 339 ? 32.09968  10.15339  21.87156  1.000 52.63500  ?  339  LYS A CB  1 
ATOM   2599 C  CG  . LYS A 1 339 ? 32.99113  10.07157  23.08682  1.000 52.32455  ?  339  LYS A CG  1 
ATOM   2600 C  CD  . LYS A 1 339 ? 33.44933  11.45093  23.55029  1.000 60.53190  ?  339  LYS A CD  1 
ATOM   2601 C  CE  . LYS A 1 339 ? 34.52808  11.33671  24.63270  1.000 64.67593  ?  339  LYS A CE  1 
ATOM   2602 N  NZ  . LYS A 1 339 ? 34.97058  12.64991  25.18802  1.000 62.39952  ?  339  LYS A NZ  1 
ATOM   2603 N  N   . GLU A 1 340 ? 32.82383  8.94496   19.01035  1.000 62.02665  ?  340  GLU A N   1 
ATOM   2604 C  CA  . GLU A 1 340 ? 33.76400  8.53235   17.96550  1.000 64.10199  ?  340  GLU A CA  1 
ATOM   2605 C  C   . GLU A 1 340 ? 35.21272  8.62928   18.43233  1.000 64.38596  ?  340  GLU A C   1 
ATOM   2606 O  O   . GLU A 1 340 ? 36.02944  7.76126   18.11446  1.000 61.28991  ?  340  GLU A O   1 
ATOM   2607 C  CB  . GLU A 1 340 ? 33.58733  9.37411   16.69689  1.000 70.43973  ?  340  GLU A CB  1 
ATOM   2608 C  CG  . GLU A 1 340 ? 32.16169  9.75023   16.31691  1.000 82.22386  ?  340  GLU A CG  1 
ATOM   2609 C  CD  . GLU A 1 340 ? 32.12863  10.74602  15.15839  1.000 89.80317  ?  340  GLU A CD  1 
ATOM   2610 O  OE1 . GLU A 1 340 ? 32.00616  10.30060  13.99571  1.000 94.58641  ?  340  GLU A OE1 1 
ATOM   2611 O  OE2 . GLU A 1 340 ? 32.24231  11.97064  15.40593  1.000 85.22669  -1 340  GLU A OE2 1 
ATOM   2612 N  N   . ASP A 1 341 ? 35.54182  9.66939   19.20887  1.000 66.11755  ?  341  ASP A N   1 
ATOM   2613 C  CA  . ASP A 1 341 ? 36.92264  9.93811   19.60877  1.000 64.85310  ?  341  ASP A CA  1 
ATOM   2614 C  C   . ASP A 1 341 ? 37.48695  8.90139   20.56695  1.000 60.85177  ?  341  ASP A C   1 
ATOM   2615 O  O   . ASP A 1 341 ? 38.71093  8.81959   20.70684  1.000 61.98101  ?  341  ASP A O   1 
ATOM   2616 C  CB  . ASP A 1 341 ? 37.02986  11.32067  20.26338  1.000 65.16014  ?  341  ASP A CB  1 
ATOM   2617 C  CG  . ASP A 1 341 ? 36.52110  12.42395  19.36441  1.000 74.66826  ?  341  ASP A CG  1 
ATOM   2618 O  OD1 . ASP A 1 341 ? 35.66829  13.21497  19.82234  1.000 77.72037  -1 341  ASP A OD1 1 
ATOM   2619 O  OD2 . ASP A 1 341 ? 36.95759  12.48457  18.19074  1.000 77.16459  -1 341  ASP A OD2 1 
ATOM   2620 N  N   . LYS A 1 342 ? 36.64148  8.14210   21.26396  1.000 61.40780  ?  342  LYS A N   1 
ATOM   2621 C  CA  . LYS A 1 342 ? 37.10577  7.10970   22.18294  1.000 50.63544  ?  342  LYS A CA  1 
ATOM   2622 C  C   . LYS A 1 342 ? 36.92723  5.71482   21.58473  1.000 50.98636  ?  342  LYS A C   1 
ATOM   2623 O  O   . LYS A 1 342 ? 37.17404  4.71064   22.25704  1.000 48.24490  ?  342  LYS A O   1 
ATOM   2624 C  CB  . LYS A 1 342 ? 36.37759  7.26511   23.53031  1.000 53.95294  ?  342  LYS A CB  1 
ATOM   2625 C  CG  . LYS A 1 342 ? 36.78657  6.32441   24.73095  1.000 60.23254  ?  342  LYS A CG  1 
ATOM   2626 C  CD  . LYS A 1 342 ? 38.22443  5.73858   24.71531  1.000 65.19251  ?  342  LYS A CD  1 
ATOM   2627 C  CE  . LYS A 1 342 ? 38.44426  4.77741   25.87332  1.000 63.16294  ?  342  LYS A CE  1 
ATOM   2628 N  NZ  . LYS A 1 342 ? 37.73017  3.49307   25.64980  1.000 62.98221  ?  342  LYS A NZ  1 
ATOM   2629 N  N   . GLU A 1 343 ? 36.54466  5.62253   20.31822  1.000 49.21284  ?  343  GLU A N   1 
ATOM   2630 C  CA  . GLU A 1 343 ? 36.44629  4.31875   19.68224  1.000 49.87888  ?  343  GLU A CA  1 
ATOM   2631 C  C   . GLU A 1 343 ? 37.83459  3.69250   19.58309  1.000 45.62596  ?  343  GLU A C   1 
ATOM   2632 O  O   . GLU A 1 343 ? 38.76146  4.29397   19.02586  1.000 45.84977  ?  343  GLU A O   1 
ATOM   2633 C  CB  . GLU A 1 343 ? 35.80635  4.44376   18.30060  1.000 49.77028  ?  343  GLU A CB  1 
ATOM   2634 C  CG  . GLU A 1 343 ? 35.60745  3.10528   17.60371  1.000 48.97199  ?  343  GLU A CG  1 
ATOM   2635 C  CD  . GLU A 1 343 ? 34.14952  2.62772   17.57091  1.000 54.93917  ?  343  GLU A CD  1 
ATOM   2636 O  OE1 . GLU A 1 343 ? 33.45503  2.70564   18.61777  1.000 51.16047  ?  343  GLU A OE1 1 
ATOM   2637 O  OE2 . GLU A 1 343 ? 33.70426  2.17826   16.48092  1.000 58.53430  -1 343  GLU A OE2 1 
ATOM   2638 N  N   . THR A 1 344 ? 37.98467  2.49990   20.14167  1.000 41.31583  ?  344  THR A N   1 
ATOM   2639 C  CA  . THR A 1 344 ? 39.18895  1.69722   19.98174  1.000 41.63014  ?  344  THR A CA  1 
ATOM   2640 C  C   . THR A 1 344 ? 38.82626  0.37523   19.30911  1.000 39.57083  ?  344  THR A C   1 
ATOM   2641 O  O   . THR A 1 344 ? 37.65614  0.09718   19.01945  1.000 39.12005  ?  344  THR A O   1 
ATOM   2642 C  CB  . THR A 1 344 ? 39.87987  1.44119   21.32469  1.000 43.75943  ?  344  THR A CB  1 
ATOM   2643 O  OG1 . THR A 1 344 ? 39.27453  0.31417   21.97463  1.000 39.60702  ?  344  THR A OG1 1 
ATOM   2644 C  CG2 . THR A 1 344 ? 39.80407  2.67158   22.22360  1.000 42.58069  ?  344  THR A CG2 1 
ATOM   2645 N  N   . ALA A 1 345 ? 39.84605  -0.45060  19.06458  1.000 36.68376  ?  345  ALA A N   1 
ATOM   2646 C  CA  . ALA A 1 345 ? 39.58804  -1.75978  18.47782  1.000 37.81115  ?  345  ALA A CA  1 
ATOM   2647 C  C   . ALA A 1 345 ? 38.63100  -2.55462  19.35493  1.000 39.32398  ?  345  ALA A C   1 
ATOM   2648 O  O   . ALA A 1 345 ? 37.69085  -3.20376  18.85949  1.000 46.36169  ?  345  ALA A O   1 
ATOM   2649 C  CB  . ALA A 1 345 ? 40.90274  -2.51545  18.29089  1.000 33.56345  ?  345  ALA A CB  1 
ATOM   2650 N  N   . LYS A 1 346 ? 38.81987  -2.46768  20.66963  1.000 35.06635  ?  346  LYS A N   1 
ATOM   2651 C  CA  . LYS A 1 346 ? 38.02333  -3.28420  21.58567  1.000 40.35270  ?  346  LYS A CA  1 
ATOM   2652 C  C   . LYS A 1 346 ? 36.58560  -2.78692  21.69355  1.000 37.07541  ?  346  LYS A C   1 
ATOM   2653 O  O   . LYS A 1 346 ? 35.63943  -3.58611  21.61002  1.000 39.15867  ?  346  LYS A O   1 
ATOM   2654 C  CB  . LYS A 1 346 ? 38.70546  -3.33696  22.95076  1.000 42.86831  ?  346  LYS A CB  1 
ATOM   2655 C  CG  . LYS A 1 346 ? 39.89238  -4.31104  22.97261  1.000 45.24963  ?  346  LYS A CG  1 
ATOM   2656 C  CD  . LYS A 1 346 ? 40.90084  -3.93287  24.03851  1.000 47.82506  ?  346  LYS A CD  1 
ATOM   2657 C  CE  . LYS A 1 346 ? 41.93250  -5.04131  24.25075  1.000 46.06475  ?  346  LYS A CE  1 
ATOM   2658 N  NZ  . LYS A 1 346 ? 42.69700  -4.82234  25.53134  1.000 45.41185  ?  346  LYS A NZ  1 
ATOM   2659 N  N   . THR A 1 347 ? 36.38530  -1.46644  21.84405  1.000 38.37577  ?  347  THR A N   1 
ATOM   2660 C  CA  . THR A 1 347 ? 35.00708  -0.96137  21.86962  1.000 37.26984  ?  347  THR A CA  1 
ATOM   2661 C  C   . THR A 1 347 ? 34.28163  -1.29310  20.56721  1.000 38.88089  ?  347  THR A C   1 
ATOM   2662 O  O   . THR A 1 347 ? 33.09731  -1.65199  20.57876  1.000 42.07204  ?  347  THR A O   1 
ATOM   2663 C  CB  . THR A 1 347 ? 34.95354  0.55036   22.12846  1.000 38.27120  ?  347  THR A CB  1 
ATOM   2664 O  OG1 . THR A 1 347 ? 35.51067  1.25206   21.01615  1.000 35.69155  ?  347  THR A OG1 1 
ATOM   2665 C  CG2 . THR A 1 347 ? 35.69756  0.94227   23.42725  1.000 42.04093  ?  347  THR A CG2 1 
ATOM   2666 N  N   . ARG A 1 348 ? 34.98397  -1.19460  19.43473  1.000 40.42598  ?  348  ARG A N   1 
ATOM   2667 C  CA  . ARG A 1 348 ? 34.39896  -1.57927  18.15359  1.000 41.51511  ?  348  ARG A CA  1 
ATOM   2668 C  C   . ARG A 1 348 ? 33.86380  -3.00583  18.21302  1.000 43.31571  ?  348  ARG A C   1 
ATOM   2669 O  O   . ARG A 1 348 ? 32.76138  -3.28129  17.71378  1.000 43.28558  ?  348  ARG A O   1 
ATOM   2670 C  CB  . ARG A 1 348 ? 35.44359  -1.44786  17.03309  1.000 39.94374  ?  348  ARG A CB  1 
ATOM   2671 C  CG  . ARG A 1 348 ? 34.89990  -1.51426  15.61172  1.000 44.39951  ?  348  ARG A CG  1 
ATOM   2672 C  CD  . ARG A 1 348 ? 35.87800  -0.88900  14.59755  1.000 43.79103  ?  348  ARG A CD  1 
ATOM   2673 N  NE  . ARG A 1 348 ? 35.55354  -1.23566  13.21727  1.000 44.32050  ?  348  ARG A NE  1 
ATOM   2674 C  CZ  . ARG A 1 348 ? 36.06119  -2.28854  12.59320  1.000 43.19442  ?  348  ARG A CZ  1 
ATOM   2675 N  NH1 . ARG A 1 348 ? 36.89846  -3.10810  13.20813  1.000 34.34411  ?  348  ARG A NH1 1 
ATOM   2676 N  NH2 . ARG A 1 348 ? 35.71508  -2.52793  11.32868  1.000 36.60535  ?  348  ARG A NH2 1 
ATOM   2677 N  N   . LEU A 1 349 ? 34.62435  -3.92918  18.83717  1.000 34.38101  ?  349  LEU A N   1 
ATOM   2678 C  CA  . LEU A 1 349 ? 34.16673  -5.32013  18.86724  1.000 39.62391  ?  349  LEU A CA  1 
ATOM   2679 C  C   . LEU A 1 349 ? 33.07729  -5.58595  19.90971  1.000 41.88006  ?  349  LEU A C   1 
ATOM   2680 O  O   . LEU A 1 349 ? 32.40178  -6.62203  19.82913  1.000 39.05851  ?  349  LEU A O   1 
ATOM   2681 C  CB  . LEU A 1 349 ? 35.35867  -6.26917  19.09489  1.000 37.34427  ?  349  LEU A CB  1 
ATOM   2682 C  CG  . LEU A 1 349 ? 36.47534  -6.05876  18.04818  1.000 32.66802  ?  349  LEU A CG  1 
ATOM   2683 C  CD1 . LEU A 1 349 ? 37.77620  -6.78937  18.39084  1.000 35.28061  ?  349  LEU A CD1 1 
ATOM   2684 C  CD2 . LEU A 1 349 ? 36.00683  -6.41642  16.62679  1.000 35.05109  ?  349  LEU A CD2 1 
ATOM   2685 N  N   . ALA A 1 350 ? 32.87441  -4.70223  20.89140  1.000 41.03806  ?  350  ALA A N   1 
ATOM   2686 C  CA  . ALA A 1 350 ? 31.88148  -5.05747  21.90812  1.000 33.04918  ?  350  ALA A CA  1 
ATOM   2687 C  C   . ALA A 1 350 ? 30.42332  -4.78467  21.48273  1.000 38.06727  ?  350  ALA A C   1 
ATOM   2688 O  O   . ALA A 1 350 ? 29.53209  -4.77905  22.33330  1.000 40.66722  ?  350  ALA A O   1 
ATOM   2689 C  CB  . ALA A 1 350 ? 32.18792  -4.34820  23.22501  1.000 34.23514  ?  350  ALA A CB  1 
ATOM   2690 N  N   . THR A 1 351 ? 30.13962  -4.61980  20.19786  1.000 35.74869  ?  351  THR A N   1 
ATOM   2691 C  CA  . THR A 1 351 ? 28.78962  -4.34057  19.73538  1.000 34.06259  ?  351  THR A CA  1 
ATOM   2692 C  C   . THR A 1 351 ? 27.90518  -5.59709  19.71651  1.000 31.59412  ?  351  THR A C   1 
ATOM   2693 O  O   . THR A 1 351 ? 28.38450  -6.73442  19.64254  1.000 35.75523  ?  351  THR A O   1 
ATOM   2694 C  CB  . THR A 1 351 ? 28.86096  -3.69690  18.35795  1.000 37.11492  ?  351  THR A CB  1 
ATOM   2695 O  OG1 . THR A 1 351 ? 29.73491  -4.46607  17.52733  1.000 36.75969  ?  351  THR A OG1 1 
ATOM   2696 C  CG2 . THR A 1 351 ? 29.44282  -2.30085  18.50027  1.000 32.86852  ?  351  THR A CG2 1 
ATOM   2697 N  N   . GLU A 1 352 ? 26.59146  -5.37538  19.78853  1.000 31.17612  ?  352  GLU A N   1 
ATOM   2698 C  CA  . GLU A 1 352 ? 25.62576  -6.46608  19.94154  1.000 37.51579  ?  352  GLU A CA  1 
ATOM   2699 C  C   . GLU A 1 352 ? 25.30100  -7.09873  18.59296  1.000 30.60168  ?  352  GLU A C   1 
ATOM   2700 O  O   . GLU A 1 352 ? 25.10271  -6.40047  17.60407  1.000 31.62718  ?  352  GLU A O   1 
ATOM   2701 C  CB  . GLU A 1 352 ? 24.32336  -5.95234  20.56955  1.000 38.42781  ?  352  GLU A CB  1 
ATOM   2702 C  CG  . GLU A 1 352 ? 24.38227  -5.50007  22.02876  1.000 39.89768  ?  352  GLU A CG  1 
ATOM   2703 C  CD  . GLU A 1 352 ? 24.67287  -6.64769  23.00960  1.000 48.69387  ?  352  GLU A CD  1 
ATOM   2704 O  OE1 . GLU A 1 352 ? 24.56691  -7.83270  22.61257  1.000 39.56573  ?  352  GLU A OE1 1 
ATOM   2705 O  OE2 . GLU A 1 352 ? 25.01053  -6.35534  24.18512  1.000 50.47462  -1 352  GLU A OE2 1 
ATOM   2706 N  N   . ASN A 1 353 ? 25.23289  -8.42338  18.53727  1.000 33.07004  ?  353  ASN A N   1 
ATOM   2707 C  CA  . ASN A 1 353 ? 24.79615  -9.03568  17.29059  1.000 30.18539  ?  353  ASN A CA  1 
ATOM   2708 C  C   . ASN A 1 353 ? 23.52200  -9.85676  17.43101  1.000 25.28430  ?  353  ASN A C   1 
ATOM   2709 O  O   . ASN A 1 353 ? 23.08433  -10.44571 16.43948  1.000 34.23422  ?  353  ASN A O   1 
ATOM   2710 C  CB  . ASN A 1 353 ? 25.92332  -9.86997  16.64214  1.000 30.01450  ?  353  ASN A CB  1 
ATOM   2711 C  CG  . ASN A 1 353 ? 26.28399  -11.13948 17.43084  1.000 30.53886  ?  353  ASN A CG  1 
ATOM   2712 O  OD1 . ASN A 1 353 ? 25.65839  -11.48316 18.43773  1.000 32.73875  ?  353  ASN A OD1 1 
ATOM   2713 N  ND2 . ASN A 1 353 ? 27.31189  -11.82744 16.96984  1.000 28.11410  ?  353  ASN A ND2 1 
ATOM   2714 N  N   . TRP A 1 354 ? 22.89557  -9.87424  18.60632  1.000 25.41782  ?  354  TRP A N   1 
ATOM   2715 C  CA  . TRP A 1 354 ? 21.62163  -10.57234 18.82743  1.000 31.45879  ?  354  TRP A CA  1 
ATOM   2716 C  C   . TRP A 1 354 ? 21.71916  -12.05085 18.46467  1.000 28.02708  ?  354  TRP A C   1 
ATOM   2717 O  O   . TRP A 1 354 ? 20.76442  -12.63680 17.96370  1.000 27.89751  ?  354  TRP A O   1 
ATOM   2718 C  CB  . TRP A 1 354 ? 20.46048  -9.93688  18.03964  1.000 27.07744  ?  354  TRP A CB  1 
ATOM   2719 C  CG  . TRP A 1 354 ? 19.90662  -8.64710  18.56321  1.000 27.34701  ?  354  TRP A CG  1 
ATOM   2720 C  CD1 . TRP A 1 354 ? 20.41652  -7.85847  19.55406  1.000 27.58794  ?  354  TRP A CD1 1 
ATOM   2721 C  CD2 . TRP A 1 354 ? 18.73652  -7.97877  18.08036  1.000 24.09036  ?  354  TRP A CD2 1 
ATOM   2722 N  NE1 . TRP A 1 354 ? 19.61455  -6.74245  19.73792  1.000 29.20079  ?  354  TRP A NE1 1 
ATOM   2723 C  CE2 . TRP A 1 354 ? 18.58656  -6.78884  18.83545  1.000 28.41983  ?  354  TRP A CE2 1 
ATOM   2724 C  CE3 . TRP A 1 354 ? 17.80593  -8.26908  17.07736  1.000 22.94502  ?  354  TRP A CE3 1 
ATOM   2725 C  CZ2 . TRP A 1 354 ? 17.54615  -5.89050  18.61567  1.000 28.19574  ?  354  TRP A CZ2 1 
ATOM   2726 C  CZ3 . TRP A 1 354 ? 16.76518  -7.36657  16.85443  1.000 31.36170  ?  354  TRP A CZ3 1 
ATOM   2727 C  CH2 . TRP A 1 354 ? 16.63845  -6.20484  17.63071  1.000 25.55323  ?  354  TRP A CH2 1 
ATOM   2728 N  N   . ASP A 1 355 ? 22.87553  -12.66861 18.70023  1.000 33.41914  ?  355  ASP A N   1 
ATOM   2729 C  CA  . ASP A 1 355 ? 22.91680  -14.10903 18.45277  1.000 35.48412  ?  355  ASP A CA  1 
ATOM   2730 C  C   . ASP A 1 355 ? 22.13769  -14.92419 19.49813  1.000 42.03959  ?  355  ASP A C   1 
ATOM   2731 O  O   . ASP A 1 355 ? 22.01420  -16.14705 19.33653  1.000 49.60623  ?  355  ASP A O   1 
ATOM   2732 C  CB  . ASP A 1 355 ? 24.36445  -14.60241 18.37985  1.000 35.78185  ?  355  ASP A CB  1 
ATOM   2733 C  CG  . ASP A 1 355 ? 25.01909  -14.68809 19.74656  1.000 54.06247  ?  355  ASP A CG  1 
ATOM   2734 O  OD1 . ASP A 1 355 ? 26.17020  -14.21678 19.88709  1.000 63.81741  -1 355  ASP A OD1 1 
ATOM   2735 O  OD2 . ASP A 1 355 ? 24.37456  -15.20607 20.69565  1.000 60.63204  -1 355  ASP A OD2 1 
ATOM   2736 N  N   . ALA A 1 356 ? 21.62658  -14.29780 20.56291  1.000 41.71923  ?  356  ALA A N   1 
ATOM   2737 C  CA  . ALA A 1 356 ? 20.85479  -15.00900 21.57938  1.000 38.59317  ?  356  ALA A CA  1 
ATOM   2738 C  C   . ALA A 1 356 ? 19.53723  -15.54831 21.01285  1.000 35.24536  ?  356  ALA A C   1 
ATOM   2739 O  O   . ALA A 1 356 ? 19.00522  -15.01461 20.04042  1.000 38.04343  ?  356  ALA A O   1 
ATOM   2740 C  CB  . ALA A 1 356 ? 20.56475  -14.08523 22.75227  1.000 36.39969  ?  356  ALA A CB  1 
ATOM   2741 N  N   . PRO A 1 357 ? 18.98695  -16.61028 21.60990  1.000 34.09074  ?  357  PRO A N   1 
ATOM   2742 C  CA  . PRO A 1 357 ? 17.72042  -17.15477 21.09521  1.000 34.28590  ?  357  PRO A CA  1 
ATOM   2743 C  C   . PRO A 1 357 ? 16.49279  -16.32890 21.45751  1.000 32.50595  ?  357  PRO A C   1 
ATOM   2744 O  O   . PRO A 1 357 ? 15.49526  -16.36839 20.72602  1.000 31.29794  ?  357  PRO A O   1 
ATOM   2745 C  CB  . PRO A 1 357 ? 17.65243  -18.56065 21.72363  1.000 35.35368  ?  357  PRO A CB  1 
ATOM   2746 C  CG  . PRO A 1 357 ? 18.54591  -18.50154 22.89531  1.000 38.68787  ?  357  PRO A CG  1 
ATOM   2747 C  CD  . PRO A 1 357 ? 19.62054  -17.50900 22.59254  1.000 37.98573  ?  357  PRO A CD  1 
ATOM   2748 N  N   . LEU A 1 358 ? 16.50040  -15.60275 22.56359  1.000 30.13228  ?  358  LEU A N   1 
ATOM   2749 C  CA  . LEU A 1 358 ? 15.34179  -14.79815 22.93698  1.000 35.52282  ?  358  LEU A CA  1 
ATOM   2750 C  C   . LEU A 1 358 ? 15.81341  -13.37404 23.19427  1.000 33.36214  ?  358  LEU A C   1 
ATOM   2751 O  O   . LEU A 1 358 ? 16.64113  -13.14386 24.07499  1.000 34.38699  ?  358  LEU A O   1 
ATOM   2752 C  CB  . LEU A 1 358 ? 14.61787  -15.38647 24.15462  1.000 32.10029  ?  358  LEU A CB  1 
ATOM   2753 C  CG  . LEU A 1 358 ? 13.40096  -14.61283 24.69305  1.000 35.66928  ?  358  LEU A CG  1 
ATOM   2754 C  CD1 . LEU A 1 358 ? 12.23280  -14.53717 23.74264  1.000 36.36074  ?  358  LEU A CD1 1 
ATOM   2755 C  CD2 . LEU A 1 358 ? 12.95580  -15.29810 25.94410  1.000 49.42651  ?  358  LEU A CD2 1 
ATOM   2756 N  N   . ILE A 1 359 ? 15.30295  -12.42580 22.41734  1.000 33.84331  ?  359  ILE A N   1 
ATOM   2757 C  CA  . ILE A 1 359 ? 15.73661  -11.03997 22.49461  1.000 31.45215  ?  359  ILE A CA  1 
ATOM   2758 C  C   . ILE A 1 359 ? 14.52605  -10.18268 22.85610  1.000 35.79440  ?  359  ILE A C   1 
ATOM   2759 O  O   . ILE A 1 359 ? 13.45791  -10.33415 22.24989  1.000 31.59475  ?  359  ILE A O   1 
ATOM   2760 C  CB  . ILE A 1 359 ? 16.36822  -10.57291 21.16919  1.000 36.73659  ?  359  ILE A CB  1 
ATOM   2761 C  CG1 . ILE A 1 359 ? 17.54887  -11.47696 20.77643  1.000 29.09236  ?  359  ILE A CG1 1 
ATOM   2762 C  CG2 . ILE A 1 359 ? 16.86986  -9.11260  21.27575  1.000 28.20258  ?  359  ILE A CG2 1 
ATOM   2763 C  CD1 . ILE A 1 359 ? 17.63191  -11.62340 19.30083  1.000 27.31695  ?  359  ILE A CD1 1 
ATOM   2764 N  N   . VAL A 1 360 ? 14.68951  -9.30384  23.85610  1.000 28.49161  ?  360  VAL A N   1 
ATOM   2765 C  CA  . VAL A 1 360 ? 13.66972  -8.34192  24.26119  1.000 30.08782  ?  360  VAL A CA  1 
ATOM   2766 C  C   . VAL A 1 360 ? 14.21904  -6.94326  23.99345  1.000 31.80857  ?  360  VAL A C   1 
ATOM   2767 O  O   . VAL A 1 360 ? 15.28215  -6.57691  24.51079  1.000 28.35725  ?  360  VAL A O   1 
ATOM   2768 C  CB  . VAL A 1 360 ? 13.27294  -8.49966  25.74454  1.000 32.89395  ?  360  VAL A CB  1 
ATOM   2769 C  CG1 . VAL A 1 360 ? 12.20824  -7.44478  26.14550  1.000 30.90533  ?  360  VAL A CG1 1 
ATOM   2770 C  CG2 . VAL A 1 360 ? 12.74444  -9.86671  25.99543  1.000 31.57700  ?  360  VAL A CG2 1 
ATOM   2771 N  N   . THR A 1 361 ? 13.47642  -6.15463  23.21869  1.000 30.09124  ?  361  THR A N   1 
ATOM   2772 C  CA  . THR A 1 361 ? 14.00658  -4.91771  22.64864  1.000 32.19336  ?  361  THR A CA  1 
ATOM   2773 C  C   . THR A 1 361 ? 12.83266  -3.96701  22.43783  1.000 32.65564  ?  361  THR A C   1 
ATOM   2774 O  O   . THR A 1 361 ? 11.67611  -4.32550  22.69298  1.000 34.96819  ?  361  THR A O   1 
ATOM   2775 C  CB  . THR A 1 361 ? 14.76626  -5.19600  21.32771  1.000 31.69166  ?  361  THR A CB  1 
ATOM   2776 O  OG1 . THR A 1 361 ? 15.54075  -4.05612  20.95798  1.000 32.98179  ?  361  THR A OG1 1 
ATOM   2777 C  CG2 . THR A 1 361 ? 13.80926  -5.53208  20.16855  1.000 22.45107  ?  361  THR A CG2 1 
ATOM   2778 N  N   . THR A 1 362 ? 13.12631  -2.74259  21.99005  1.000 27.17650  ?  362  THR A N   1 
ATOM   2779 C  CA  . THR A 1 362 ? 12.05966  -1.84260  21.56107  1.000 31.96531  ?  362  THR A CA  1 
ATOM   2780 C  C   . THR A 1 362 ? 11.88690  -1.95287  20.05057  1.000 30.65536  ?  362  THR A C   1 
ATOM   2781 O  O   . THR A 1 362 ? 12.79604  -2.37531  19.33657  1.000 28.52772  ?  362  THR A O   1 
ATOM   2782 C  CB  . THR A 1 362 ? 12.33819  -0.37904  21.92513  1.000 31.95485  ?  362  THR A CB  1 
ATOM   2783 O  OG1 . THR A 1 362 ? 13.53109  0.05270   21.26084  1.000 33.40463  ?  362  THR A OG1 1 
ATOM   2784 C  CG2 . THR A 1 362 ? 12.46534  -0.15263  23.47395  1.000 28.66196  ?  362  THR A CG2 1 
ATOM   2785 N  N   . ASN A 1 363 ? 10.70002  -1.56468  19.56150  1.000 30.80724  ?  363  ASN A N   1 
ATOM   2786 C  CA  . ASN A 1 363 ? 10.52984  -1.50765  18.11407  1.000 29.66197  ?  363  ASN A CA  1 
ATOM   2787 C  C   . ASN A 1 363 ? 11.41451  -0.42455  17.49352  1.000 29.55121  ?  363  ASN A C   1 
ATOM   2788 O  O   . ASN A 1 363 ? 11.79543  -0.53673  16.31558  1.000 28.10064  ?  363  ASN A O   1 
ATOM   2789 C  CB  . ASN A 1 363 ? 9.04077   -1.32312  17.73685  1.000 26.59021  ?  363  ASN A CB  1 
ATOM   2790 C  CG  . ASN A 1 363 ? 8.34758   -0.27428  18.55738  1.000 33.27139  ?  363  ASN A CG  1 
ATOM   2791 O  OD1 . ASN A 1 363 ? 8.94124   0.73436   18.95877  1.000 30.23015  ?  363  ASN A OD1 1 
ATOM   2792 N  ND2 . ASN A 1 363 ? 7.07782   -0.50466  18.82595  1.000 33.54334  ?  363  ASN A ND2 1 
ATOM   2793 N  N   . VAL A 1 364 ? 11.78783  0.59133   18.26965  1.000 29.50342  ?  364  VAL A N   1 
ATOM   2794 C  CA  . VAL A 1 364 ? 12.70544  1.61478   17.76718  1.000 28.62150  ?  364  VAL A CA  1 
ATOM   2795 C  C   . VAL A 1 364 ? 14.09982  1.01986   17.55444  1.000 29.26408  ?  364  VAL A C   1 
ATOM   2796 O  O   . VAL A 1 364 ? 14.70925  1.19012   16.49596  1.000 27.07693  ?  364  VAL A O   1 
ATOM   2797 C  CB  . VAL A 1 364 ? 12.73273  2.83205   18.72493  1.000 33.02135  ?  364  VAL A CB  1 
ATOM   2798 C  CG1 . VAL A 1 364 ? 14.00898  3.64939   18.56914  1.000 34.67253  ?  364  VAL A CG1 1 
ATOM   2799 C  CG2 . VAL A 1 364 ? 11.53221  3.74690   18.48065  1.000 37.30025  ?  364  VAL A CG2 1 
ATOM   2800 N  N   . GLN A 1 365 ? 14.62944  0.31514   18.55190  1.000 28.33241  ?  365  GLN A N   1 
ATOM   2801 C  CA  . GLN A 1 365 ? 15.89545  -0.37765  18.34361  1.000 32.42558  ?  365  GLN A CA  1 
ATOM   2802 C  C   . GLN A 1 365 ? 15.81553  -1.28805  17.11916  1.000 28.08103  ?  365  GLN A C   1 
ATOM   2803 O  O   . GLN A 1 365 ? 16.68058  -1.23679  16.24094  1.000 29.20552  ?  365  GLN A O   1 
ATOM   2804 C  CB  . GLN A 1 365 ? 16.28543  -1.16803  19.60249  1.000 28.21537  ?  365  GLN A CB  1 
ATOM   2805 C  CG  . GLN A 1 365 ? 17.64205  -1.91991  19.50503  1.000 34.00493  ?  365  GLN A CG  1 
ATOM   2806 C  CD  . GLN A 1 365 ? 18.83511  -0.99414  19.20293  1.000 41.37074  ?  365  GLN A CD  1 
ATOM   2807 O  OE1 . GLN A 1 365 ? 19.59164  -1.22315  18.24407  1.000 33.10781  ?  365  GLN A OE1 1 
ATOM   2808 N  NE2 . GLN A 1 365 ? 18.97762  0.07764   19.99795  1.000 39.97644  ?  365  GLN A NE2 1 
ATOM   2809 N  N   . LEU A 1 366 ? 14.74256  -2.07555  17.01275  1.000 27.69073  ?  366  LEU A N   1 
ATOM   2810 C  CA  . LEU A 1 366 ? 14.62579  -3.04449  15.91652  1.000 26.76503  ?  366  LEU A CA  1 
ATOM   2811 C  C   . LEU A 1 366 ? 14.63277  -2.34423  14.55009  1.000 27.72870  ?  366  LEU A C   1 
ATOM   2812 O  O   . LEU A 1 366 ? 15.43568  -2.67466  13.65748  1.000 23.60529  ?  366  LEU A O   1 
ATOM   2813 C  CB  . LEU A 1 366 ? 13.33707  -3.86492  16.10902  1.000 23.15481  ?  366  LEU A CB  1 
ATOM   2814 C  CG  . LEU A 1 366 ? 12.80850  -4.80500  15.00303  1.000 26.16901  ?  366  LEU A CG  1 
ATOM   2815 C  CD1 . LEU A 1 366 ? 13.84501  -5.86437  14.64071  1.000 22.38780  ?  366  LEU A CD1 1 
ATOM   2816 C  CD2 . LEU A 1 366 ? 11.49213  -5.48866  15.32357  1.000 19.81354  ?  366  LEU A CD2 1 
ATOM   2817 N  N   . PHE A 1 367 ? 13.75158  -1.35426  14.36725  1.000 23.77604  ?  367  PHE A N   1 
ATOM   2818 C  CA  . PHE A 1 367 ? 13.57930  -0.83928  13.01936  1.000 23.35266  ?  367  PHE A CA  1 
ATOM   2819 C  C   . PHE A 1 367 ? 14.61417  0.22744   12.68786  1.000 24.50579  ?  367  PHE A C   1 
ATOM   2820 O  O   . PHE A 1 367 ? 15.01479  0.33906   11.52690  1.000 26.47905  ?  367  PHE A O   1 
ATOM   2821 C  CB  . PHE A 1 367 ? 12.15541  -0.31458  12.82205  1.000 28.57982  ?  367  PHE A CB  1 
ATOM   2822 C  CG  . PHE A 1 367 ? 11.14694  -1.41097  12.67464  1.000 25.86151  ?  367  PHE A CG  1 
ATOM   2823 C  CD1 . PHE A 1 367 ? 11.15159  -2.23964  11.55062  1.000 24.76297  ?  367  PHE A CD1 1 
ATOM   2824 C  CD2 . PHE A 1 367 ? 10.21471  -1.63850  13.67194  1.000 24.07758  ?  367  PHE A CD2 1 
ATOM   2825 C  CE1 . PHE A 1 367 ? 10.20636  -3.26509  11.42931  1.000 28.09574  ?  367  PHE A CE1 1 
ATOM   2826 C  CE2 . PHE A 1 367 ? 9.27721   -2.67106  13.56543  1.000 32.09974  ?  367  PHE A CE2 1 
ATOM   2827 C  CZ  . PHE A 1 367 ? 9.27792   -3.49471  12.45025  1.000 23.32562  ?  367  PHE A CZ  1 
ATOM   2828 N  N   . GLU A 1 368 ? 15.09938  0.98605   13.67478  1.000 25.09723  ?  368  GLU A N   1 
ATOM   2829 C  CA  . GLU A 1 368 ? 16.23785  1.85384   13.40250  1.000 27.01827  ?  368  GLU A CA  1 
ATOM   2830 C  C   . GLU A 1 368 ? 17.50085  1.03743   13.11307  1.000 32.44989  ?  368  GLU A C   1 
ATOM   2831 O  O   . GLU A 1 368 ? 18.35585  1.49188   12.33964  1.000 30.53630  ?  368  GLU A O   1 
ATOM   2832 C  CB  . GLU A 1 368 ? 16.45346  2.84361   14.55244  1.000 35.40038  ?  368  GLU A CB  1 
ATOM   2833 C  CG  . GLU A 1 368 ? 17.41871  3.94950   14.18741  1.000 38.19863  ?  368  GLU A CG  1 
ATOM   2834 C  CD  . GLU A 1 368 ? 17.52002  5.05870   15.22265  1.000 52.41500  ?  368  GLU A CD  1 
ATOM   2835 O  OE1 . GLU A 1 368 ? 17.01216  4.88761   16.35423  1.000 53.00536  ?  368  GLU A OE1 1 
ATOM   2836 O  OE2 . GLU A 1 368 ? 18.13404  6.10602   14.89334  1.000 60.84704  -1 368  GLU A OE2 1 
ATOM   2837 N  N   . SER A 1 369 ? 17.63692  -0.18594  13.66429  1.000 26.55571  ?  369  SER A N   1 
ATOM   2838 C  CA  . SER A 1 369 ? 18.74266  -1.02374  13.19774  1.000 27.78807  ?  369  SER A CA  1 
ATOM   2839 C  C   . SER A 1 369 ? 18.51029  -1.48494  11.76167  1.000 28.88156  ?  369  SER A C   1 
ATOM   2840 O  O   . SER A 1 369 ? 19.43674  -1.45240  10.93551  1.000 30.83578  ?  369  SER A O   1 
ATOM   2841 C  CB  . SER A 1 369 ? 18.94343  -2.22233  14.12014  1.000 29.95614  ?  369  SER A CB  1 
ATOM   2842 O  OG  . SER A 1 369 ? 19.24125  -1.80175  15.43673  1.000 33.37584  ?  369  SER A OG  1 
ATOM   2843 N  N   . LEU A 1 370 ? 17.28098  -1.89702  11.43226  1.000 27.39424  ?  370  LEU A N   1 
ATOM   2844 C  CA  . LEU A 1 370 ? 17.01431  -2.34818  10.06259  1.000 27.50927  ?  370  LEU A CA  1 
ATOM   2845 C  C   . LEU A 1 370 ? 17.21899  -1.23918  9.01878   1.000 27.69449  ?  370  LEU A C   1 
ATOM   2846 O  O   . LEU A 1 370 ? 17.39998  -1.52131  7.83408   1.000 24.90477  ?  370  LEU A O   1 
ATOM   2847 C  CB  . LEU A 1 370 ? 15.59417  -2.90880  9.96127   1.000 22.27567  ?  370  LEU A CB  1 
ATOM   2848 C  CG  . LEU A 1 370 ? 15.48756  -4.36297  10.47551  1.000 29.14302  ?  370  LEU A CG  1 
ATOM   2849 C  CD1 . LEU A 1 370 ? 14.01908  -4.77745  10.63474  1.000 23.07573  ?  370  LEU A CD1 1 
ATOM   2850 C  CD2 . LEU A 1 370 ? 16.22785  -5.29820  9.53005   1.000 21.38570  ?  370  LEU A CD2 1 
ATOM   2851 N  N   . PHE A 1 371 ? 17.19461  0.01691   9.41112   1.000 27.31799  ?  371  PHE A N   1 
ATOM   2852 C  CA  . PHE A 1 371 ? 17.40564  1.06625   8.42666   1.000 26.33635  ?  371  PHE A CA  1 
ATOM   2853 C  C   . PHE A 1 371 ? 18.76410  1.73591   8.57655   1.000 27.23760  ?  371  PHE A C   1 
ATOM   2854 O  O   . PHE A 1 371 ? 18.95514  2.85607   8.06856   1.000 27.82902  ?  371  PHE A O   1 
ATOM   2855 C  CB  . PHE A 1 371 ? 16.27611  2.09377   8.52512   1.000 28.95552  ?  371  PHE A CB  1 
ATOM   2856 C  CG  . PHE A 1 371 ? 15.01709  1.67959   7.82236   1.000 29.44010  ?  371  PHE A CG  1 
ATOM   2857 C  CD1 . PHE A 1 371 ? 14.83746  1.96920   6.47143   1.000 29.82135  ?  371  PHE A CD1 1 
ATOM   2858 C  CD2 . PHE A 1 371 ? 13.99983  1.02457   8.51213   1.000 24.75613  ?  371  PHE A CD2 1 
ATOM   2859 C  CE1 . PHE A 1 371 ? 13.65815  1.59986   5.80814   1.000 28.98835  ?  371  PHE A CE1 1 
ATOM   2860 C  CE2 . PHE A 1 371 ? 12.82355  0.67078   7.86427   1.000 29.11686  ?  371  PHE A CE2 1 
ATOM   2861 C  CZ  . PHE A 1 371 ? 12.66111  0.94542   6.50252   1.000 30.58367  ?  371  PHE A CZ  1 
ATOM   2862 N  N   . ALA A 1 372 ? 19.71931  1.08646   9.26159   1.000 25.07183  ?  372  ALA A N   1 
ATOM   2863 C  CA  . ALA A 1 372 ? 20.92089  1.81209   9.66170   1.000 28.70731  ?  372  ALA A CA  1 
ATOM   2864 C  C   . ALA A 1 372 ? 22.03876  1.74014   8.62376   1.000 27.02934  ?  372  ALA A C   1 
ATOM   2865 O  O   . ALA A 1 372 ? 22.01558  0.95288   7.67001   1.000 24.08060  ?  372  ALA A O   1 
ATOM   2866 C  CB  . ALA A 1 372 ? 21.45546  1.33032   11.00416  1.000 25.46440  ?  372  ALA A CB  1 
ATOM   2867 N  N   . ALA A 1 373 ? 23.00721  2.63829   8.79920   1.000 30.55378  ?  373  ALA A N   1 
ATOM   2868 C  CA  . ALA A 1 373 ? 24.19945  2.65170   7.96737   1.000 33.64477  ?  373  ALA A CA  1 
ATOM   2869 C  C   . ALA A 1 373 ? 25.46053  2.18186   8.69414   1.000 30.39677  ?  373  ALA A C   1 
ATOM   2870 O  O   . ALA A 1 373 ? 26.30953  1.55599   8.06183   1.000 30.21231  ?  373  ALA A O   1 
ATOM   2871 C  CB  . ALA A 1 373 ? 24.42408  4.05996   7.39723   1.000 24.84052  ?  373  ALA A CB  1 
ATOM   2872 N  N   . LYS A 1 374 ? 25.58181  2.44610   10.00206  1.000 26.53659  ?  374  LYS A N   1 
ATOM   2873 C  CA  . LYS A 1 374 ? 26.79307  2.19515   10.78599  1.000 28.93632  ?  374  LYS A CA  1 
ATOM   2874 C  C   . LYS A 1 374 ? 26.94765  0.71429   11.12602  1.000 29.05554  ?  374  LYS A C   1 
ATOM   2875 O  O   . LYS A 1 374 ? 25.95452  -0.00089  11.29733  1.000 32.00399  ?  374  LYS A O   1 
ATOM   2876 C  CB  . LYS A 1 374 ? 26.74179  2.97664   12.10971  1.000 33.80005  ?  374  LYS A CB  1 
ATOM   2877 C  CG  . LYS A 1 374 ? 26.58296  4.48092   11.95534  1.000 43.45028  ?  374  LYS A CG  1 
ATOM   2878 C  CD  . LYS A 1 374 ? 25.50034  4.99577   12.94379  1.000 49.07322  ?  374  LYS A CD  1 
ATOM   2879 C  CE  . LYS A 1 374 ? 24.09420  4.36689   12.65709  1.000 51.06774  ?  374  LYS A CE  1 
ATOM   2880 N  NZ  . LYS A 1 374 ? 23.47540  4.53069   11.29060  1.000 24.30630  ?  374  LYS A NZ  1 
ATOM   2881 N  N   . THR A 1 375 ? 28.20228  0.27290   11.30299  1.000 30.64672  ?  375  THR A N   1 
ATOM   2882 C  CA  . THR A 1 375 ? 28.43593  -1.14387  11.61835  1.000 30.12144  ?  375  THR A CA  1 
ATOM   2883 C  C   . THR A 1 375 ? 27.85858  -1.52866  12.98000  1.000 31.90252  ?  375  THR A C   1 
ATOM   2884 O  O   . THR A 1 375 ? 27.34272  -2.64076  13.13422  1.000 32.87436  ?  375  THR A O   1 
ATOM   2885 C  CB  . THR A 1 375 ? 29.92609  -1.49219  11.58633  1.000 27.04218  ?  375  THR A CB  1 
ATOM   2886 O  OG1 . THR A 1 375 ? 30.64232  -0.73066  12.57385  1.000 34.72610  ?  375  THR A OG1 1 
ATOM   2887 C  CG2 . THR A 1 375 ? 30.49829  -1.22795  10.23465  1.000 31.16479  ?  375  THR A CG2 1 
ATOM   2888 N  N   . SER A 1 376 ? 27.88698  -0.62170  13.96402  1.000 31.38127  ?  376  SER A N   1 
ATOM   2889 C  CA  . SER A 1 376 ? 27.40032  -1.00123  15.28755  1.000 33.36300  ?  376  SER A CA  1 
ATOM   2890 C  C   . SER A 1 376 ? 25.91679  -1.35380  15.25139  1.000 34.42222  ?  376  SER A C   1 
ATOM   2891 O  O   . SER A 1 376 ? 25.48180  -2.30173  15.91618  1.000 29.72603  ?  376  SER A O   1 
ATOM   2892 C  CB  . SER A 1 376 ? 27.66641  0.10821   16.29597  1.000 29.99927  ?  376  SER A CB  1 
ATOM   2893 O  OG  . SER A 1 376 ? 26.97940  1.28716   15.92044  1.000 42.68432  ?  376  SER A OG  1 
ATOM   2894 N  N   . ARG A 1 377 ? 25.11758  -0.61146  14.47262  1.000 31.72870  ?  377  ARG A N   1 
ATOM   2895 C  CA  . ARG A 1 377 ? 23.69723  -0.93822  14.39317  1.000 28.47900  ?  377  ARG A CA  1 
ATOM   2896 C  C   . ARG A 1 377 ? 23.40096  -2.05127  13.39566  1.000 31.12369  ?  377  ARG A C   1 
ATOM   2897 O  O   . ARG A 1 377 ? 22.38348  -2.75281  13.54139  1.000 25.78129  ?  377  ARG A O   1 
ATOM   2898 C  CB  . ARG A 1 377 ? 22.87533  0.28522   14.00282  1.000 34.13815  ?  377  ARG A CB  1 
ATOM   2899 C  CG  . ARG A 1 377 ? 23.19090  1.57249   14.78022  1.000 37.15367  ?  377  ARG A CG  1 
ATOM   2900 C  CD  . ARG A 1 377 ? 23.08354  1.33247   16.27768  1.000 44.22193  ?  377  ARG A CD  1 
ATOM   2901 N  NE  . ARG A 1 377 ? 21.70840  1.09567   16.71317  1.000 47.24938  ?  377  ARG A NE  1 
ATOM   2902 C  CZ  . ARG A 1 377 ? 20.70085  1.95222   16.58394  1.000 47.25672  ?  377  ARG A CZ  1 
ATOM   2903 N  NH1 . ARG A 1 377 ? 20.88196  3.17329   16.09421  1.000 55.46240  ?  377  ARG A NH1 1 
ATOM   2904 N  NH2 . ARG A 1 377 ? 19.48581  1.58576   16.98337  1.000 40.25857  ?  377  ARG A NH2 1 
ATOM   2905 N  N   . CYS A 1 378 ? 24.22295  -2.17076  12.34175  1.000 26.67792  ?  378  CYS A N   1 
ATOM   2906 C  CA  . CYS A 1 378 ? 23.95255  -3.11422  11.27532  1.000 27.43681  ?  378  CYS A CA  1 
ATOM   2907 C  C   . CYS A 1 378 ? 24.40432  -4.53609  11.61437  1.000 26.26145  ?  378  CYS A C   1 
ATOM   2908 O  O   . CYS A 1 378 ? 23.84345  -5.47391  11.04836  1.000 31.07675  ?  378  CYS A O   1 
ATOM   2909 C  CB  . CYS A 1 378 ? 24.62650  -2.65529  9.97330   1.000 29.08766  ?  378  CYS A CB  1 
ATOM   2910 S  SG  . CYS A 1 378 ? 23.77599  -1.35916  9.00779   1.000 29.28954  ?  378  CYS A SG  1 
ATOM   2911 N  N   . ARG A 1 379 ? 25.38506  -4.71257  12.52582  1.000 25.51314  ?  379  ARG A N   1 
ATOM   2912 C  CA  . ARG A 1 379 ? 25.87197  -6.05153  12.91392  1.000 30.81483  ?  379  ARG A CA  1 
ATOM   2913 C  C   . ARG A 1 379 ? 24.75400  -7.08132  13.18249  1.000 27.33503  ?  379  ARG A C   1 
ATOM   2914 O  O   . ARG A 1 379 ? 24.81423  -8.22203  12.70938  1.000 29.99452  ?  379  ARG A O   1 
ATOM   2915 C  CB  . ARG A 1 379 ? 26.74800  -5.91560  14.16201  1.000 36.80200  ?  379  ARG A CB  1 
ATOM   2916 C  CG  . ARG A 1 379 ? 27.67244  -7.09155  14.36937  1.000 30.37424  ?  379  ARG A CG  1 
ATOM   2917 C  CD  . ARG A 1 379 ? 28.37308  -7.06954  15.71396  1.000 30.87392  ?  379  ARG A CD  1 
ATOM   2918 N  NE  . ARG A 1 379 ? 29.15598  -8.29711  15.83580  1.000 29.86999  ?  379  ARG A NE  1 
ATOM   2919 C  CZ  . ARG A 1 379 ? 30.11098  -8.50471  16.72929  1.000 33.36874  ?  379  ARG A CZ  1 
ATOM   2920 N  NH1 . ARG A 1 379 ? 30.48051  -7.55672  17.59018  1.000 29.00426  ?  379  ARG A NH1 1 
ATOM   2921 N  NH2 . ARG A 1 379 ? 30.71392  -9.69133  16.75944  1.000 30.31562  ?  379  ARG A NH2 1 
ATOM   2922 N  N   . LYS A 1 380 ? 23.73219  -6.70491  13.95667  1.000 27.27780  ?  380  LYS A N   1 
ATOM   2923 C  CA  . LYS A 1 380 ? 22.66717  -7.62952  14.34695  1.000 24.10098  ?  380  LYS A CA  1 
ATOM   2924 C  C   . LYS A 1 380 ? 21.72976  -8.04954  13.20385  1.000 26.30944  ?  380  LYS A C   1 
ATOM   2925 O  O   . LYS A 1 380 ? 20.99744  -9.04955  13.35428  1.000 24.78332  ?  380  LYS A O   1 
ATOM   2926 C  CB  . LYS A 1 380 ? 21.83424  -6.99020  15.46616  1.000 26.55612  ?  380  LYS A CB  1 
ATOM   2927 C  CG  . LYS A 1 380 ? 21.01111  -5.74437  14.98045  1.000 25.94690  ?  380  LYS A CG  1 
ATOM   2928 C  CD  . LYS A 1 380 ? 20.03290  -5.27653  16.05203  1.000 27.16905  ?  380  LYS A CD  1 
ATOM   2929 C  CE  . LYS A 1 380 ? 20.72351  -4.44774  17.16724  1.000 30.43301  ?  380  LYS A CE  1 
ATOM   2930 N  NZ  . LYS A 1 380 ? 21.40227  -3.22989  16.58694  1.000 24.32881  ?  380  LYS A NZ  1 
ATOM   2931 N  N   . ILE A 1 381 ? 21.73206  -7.33258  12.06849  1.000 24.85609  ?  381  ILE A N   1 
ATOM   2932 C  CA  . ILE A 1 381 ? 20.63394  -7.44966  11.10697  1.000 25.63098  ?  381  ILE A CA  1 
ATOM   2933 C  C   . ILE A 1 381 ? 20.48991  -8.89149  10.59134  1.000 30.53921  ?  381  ILE A C   1 
ATOM   2934 O  O   . ILE A 1 381 ? 19.37645  -9.41981  10.49963  1.000 30.84553  ?  381  ILE A O   1 
ATOM   2935 C  CB  . ILE A 1 381 ? 20.82867  -6.43618  9.95912   1.000 28.98983  ?  381  ILE A CB  1 
ATOM   2936 C  CG1 . ILE A 1 381 ? 20.63631  -5.00297  10.46896  1.000 33.74772  ?  381  ILE A CG1 1 
ATOM   2937 C  CG2 . ILE A 1 381 ? 19.83218  -6.66746  8.83864   1.000 27.39503  ?  381  ILE A CG2 1 
ATOM   2938 C  CD1 . ILE A 1 381 ? 20.82402  -3.93608  9.36911   1.000 27.24509  ?  381  ILE A CD1 1 
ATOM   2939 N  N   . HIS A 1 382 ? 21.59779  -9.56621  10.27544  1.000 28.25315  ?  382  HIS A N   1 
ATOM   2940 C  CA  . HIS A 1 382 ? 21.45841  -10.87414 9.62547   1.000 25.81009  ?  382  HIS A CA  1 
ATOM   2941 C  C   . HIS A 1 382 ? 20.85642  -11.93413 10.54133  1.000 26.99012  ?  382  HIS A C   1 
ATOM   2942 O  O   . HIS A 1 382 ? 20.29441  -12.91206 10.04704  1.000 29.93207  ?  382  HIS A O   1 
ATOM   2943 C  CB  . HIS A 1 382 ? 22.81779  -11.34183 9.08526   1.000 31.05143  ?  382  HIS A CB  1 
ATOM   2944 C  CG  . HIS A 1 382 ? 23.73736  -11.88017 10.14220  1.000 31.62398  ?  382  HIS A CG  1 
ATOM   2945 N  ND1 . HIS A 1 382 ? 23.74567  -13.20881 10.51963  1.000 28.48524  ?  382  HIS A ND1 1 
ATOM   2946 C  CD2 . HIS A 1 382 ? 24.65906  -11.25931 10.92003  1.000 27.11394  ?  382  HIS A CD2 1 
ATOM   2947 C  CE1 . HIS A 1 382 ? 24.64496  -13.38378 11.47368  1.000 29.10203  ?  382  HIS A CE1 1 
ATOM   2948 N  NE2 . HIS A 1 382 ? 25.20697  -12.21600 11.74069  1.000 32.71804  ?  382  HIS A NE2 1 
ATOM   2949 N  N   . ASN A 1 383 ? 20.94426  -11.75495 11.85947  1.000 28.12935  ?  383  ASN A N   1 
ATOM   2950 C  CA  . ASN A 1 383 ? 20.30593  -12.63201 12.82832  1.000 25.85907  ?  383  ASN A CA  1 
ATOM   2951 C  C   . ASN A 1 383 ? 18.80672  -12.38953 12.96316  1.000 32.00521  ?  383  ASN A C   1 
ATOM   2952 O  O   . ASN A 1 383 ? 18.11779  -13.18033 13.62107  1.000 30.45007  ?  383  ASN A O   1 
ATOM   2953 C  CB  . ASN A 1 383 ? 21.00554  -12.48771 14.18902  1.000 27.35841  ?  383  ASN A CB  1 
ATOM   2954 C  CG  . ASN A 1 383 ? 22.25592  -13.34269 14.26571  1.000 27.19740  ?  383  ASN A CG  1 
ATOM   2955 O  OD1 . ASN A 1 383 ? 22.30429  -14.40170 13.64010  1.000 29.05767  ?  383  ASN A OD1 1 
ATOM   2956 N  ND2 . ASN A 1 383 ? 23.26989  -12.88679 14.99524  1.000 24.56422  ?  383  ASN A ND2 1 
ATOM   2957 N  N   . ILE A 1 384 ? 18.27664  -11.34999 12.33124  1.000 26.62249  ?  384  ILE A N   1 
ATOM   2958 C  CA  . ILE A 1 384 ? 16.83512  -11.18873 12.31349  1.000 26.93899  ?  384  ILE A CA  1 
ATOM   2959 C  C   . ILE A 1 384 ? 16.19963  -12.07187 11.24925  1.000 23.69907  ?  384  ILE A C   1 
ATOM   2960 O  O   . ILE A 1 384 ? 15.02148  -12.44233 11.35817  1.000 22.97077  ?  384  ILE A O   1 
ATOM   2961 C  CB  . ILE A 1 384 ? 16.46031  -9.71924  12.07911  1.000 22.89299  ?  384  ILE A CB  1 
ATOM   2962 C  CG1 . ILE A 1 384 ? 17.03819  -8.83829  13.18535  1.000 24.22644  ?  384  ILE A CG1 1 
ATOM   2963 C  CG2 . ILE A 1 384 ? 14.94101  -9.56267  11.93751  1.000 25.35156  ?  384  ILE A CG2 1 
ATOM   2964 C  CD1 . ILE A 1 384 ? 17.00797  -7.38207  12.87780  1.000 22.95215  ?  384  ILE A CD1 1 
ATOM   2965 N  N   . ALA A 1 385 ? 16.91296  -12.35534 10.17360  1.000 25.30769  ?  385  ALA A N   1 
ATOM   2966 C  CA  . ALA A 1 385 ? 16.32268  -13.19171 9.15143   1.000 25.45865  ?  385  ALA A CA  1 
ATOM   2967 C  C   . ALA A 1 385 ? 15.99796  -14.56301 9.76224   1.000 25.20832  ?  385  ALA A C   1 
ATOM   2968 O  O   . ALA A 1 385 ? 16.59880  -14.97683 10.75241  1.000 26.94381  ?  385  ALA A O   1 
ATOM   2969 C  CB  . ALA A 1 385 ? 17.25740  -13.28782 7.96465   1.000 26.82784  ?  385  ALA A CB  1 
ATOM   2970 N  N   . ASP A 1 386 ? 14.92369  -15.17841 9.28447   1.000 25.68967  ?  386  ASP A N   1 
ATOM   2971 C  CA  . ASP A 1 386 ? 14.48499  -16.48216 9.80696   1.000 31.27591  ?  386  ASP A CA  1 
ATOM   2972 C  C   . ASP A 1 386 ? 14.22030  -16.44675 11.31340  1.000 32.92815  ?  386  ASP A C   1 
ATOM   2973 O  O   . ASP A 1 386 ? 14.59352  -17.36892 12.04942  1.000 29.36572  ?  386  ASP A O   1 
ATOM   2974 C  CB  . ASP A 1 386 ? 15.50405  -17.57377 9.45910   1.000 30.09170  ?  386  ASP A CB  1 
ATOM   2975 C  CG  . ASP A 1 386 ? 15.66579  -17.73275 7.94814   1.000 36.26518  ?  386  ASP A CG  1 
ATOM   2976 O  OD1 . ASP A 1 386 ? 14.65254  -18.05175 7.28848   1.000 39.51667  ?  386  ASP A OD1 1 
ATOM   2977 O  OD2 . ASP A 1 386 ? 16.77234  -17.50809 7.41848   1.000 37.74000  -1 386  ASP A OD2 1 
ATOM   2978 N  N   . SER A 1 387 ? 13.57798  -15.37589 11.78745  1.000 28.68606  ?  387  SER A N   1 
ATOM   2979 C  CA  . SER A 1 387 ? 13.22122  -15.27158 13.19921  1.000 26.41901  ?  387  SER A CA  1 
ATOM   2980 C  C   . SER A 1 387 ? 11.70980  -15.12875 13.33395  1.000 23.99177  ?  387  SER A C   1 
ATOM   2981 O  O   . SER A 1 387 ? 10.98602  -14.94369 12.35501  1.000 30.03222  ?  387  SER A O   1 
ATOM   2982 C  CB  . SER A 1 387 ? 13.93925  -14.08898 13.86887  1.000 28.73664  ?  387  SER A CB  1 
ATOM   2983 O  OG  . SER A 1 387 ? 13.17335  -12.89991 13.67863  1.000 30.60048  ?  387  SER A OG  1 
ATOM   2984 N  N   . VAL A 1 388 ? 11.22180  -15.20750 14.56247  1.000 23.59874  ?  388  VAL A N   1 
ATOM   2985 C  CA  . VAL A 1 388 ? 9.86084   -14.79209 14.86923  1.000 27.22506  ?  388  VAL A CA  1 
ATOM   2986 C  C   . VAL A 1 388 ? 9.95304   -13.46296 15.61169  1.000 29.83234  ?  388  VAL A C   1 
ATOM   2987 O  O   . VAL A 1 388 ? 10.57855  -13.37824 16.67726  1.000 26.45486  ?  388  VAL A O   1 
ATOM   2988 C  CB  . VAL A 1 388 ? 9.09881   -15.84192 15.69832  1.000 31.43247  ?  388  VAL A CB  1 
ATOM   2989 C  CG1 . VAL A 1 388 ? 7.64084   -15.42711 15.85181  1.000 23.00878  ?  388  VAL A CG1 1 
ATOM   2990 C  CG2 . VAL A 1 388 ? 9.19701   -17.23300 15.02304  1.000 25.55943  ?  388  VAL A CG2 1 
ATOM   2991 N  N   . VAL A 1 389 ? 9.31820   -12.43604 15.06502  1.000 28.57534  ?  389  VAL A N   1 
ATOM   2992 C  CA  . VAL A 1 389 ? 9.31016   -11.09734 15.66545  1.000 30.90783  ?  389  VAL A CA  1 
ATOM   2993 C  C   . VAL A 1 389 ? 7.91908   -10.81242 16.19268  1.000 28.63197  ?  389  VAL A C   1 
ATOM   2994 O  O   . VAL A 1 389 ? 6.93836   -10.82846 15.43138  1.000 29.35988  ?  389  VAL A O   1 
ATOM   2995 C  CB  . VAL A 1 389 ? 9.72175   -10.02378 14.65624  1.000 28.14885  ?  389  VAL A CB  1 
ATOM   2996 C  CG1 . VAL A 1 389 ? 9.47970   -8.60118  15.27630  1.000 26.30089  ?  389  VAL A CG1 1 
ATOM   2997 C  CG2 . VAL A 1 389 ? 11.15792  -10.23928 14.25249  1.000 22.30225  ?  389  VAL A CG2 1 
ATOM   2998 N  N   . ILE A 1 390 ? 7.82833   -10.53873 17.49003  1.000 29.78520  ?  390  ILE A N   1 
ATOM   2999 C  CA  . ILE A 1 390 ? 6.56623   -10.20571 18.13780  1.000 24.92483  ?  390  ILE A CA  1 
ATOM   3000 C  C   . ILE A 1 390 ? 6.54727   -8.69921  18.34648  1.000 29.98901  ?  390  ILE A C   1 
ATOM   3001 O  O   . ILE A 1 390 ? 7.37138   -8.17156  19.10036  1.000 31.01211  ?  390  ILE A O   1 
ATOM   3002 C  CB  . ILE A 1 390 ? 6.41782   -10.95245 19.47003  1.000 31.63400  ?  390  ILE A CB  1 
ATOM   3003 C  CG1 . ILE A 1 390 ? 6.55578   -12.46972 19.24847  1.000 30.17903  ?  390  ILE A CG1 1 
ATOM   3004 C  CG2 . ILE A 1 390 ? 5.10454   -10.61306 20.14432  1.000 31.67675  ?  390  ILE A CG2 1 
ATOM   3005 C  CD1 . ILE A 1 390 ? 6.57833   -13.28519 20.53467  1.000 26.11687  ?  390  ILE A CD1 1 
ATOM   3006 N  N   . LEU A 1 391 ? 5.61959   -8.00324  17.68529  1.000 26.60628  ?  391  LEU A N   1 
ATOM   3007 C  CA  . LEU A 1 391 ? 5.45795   -6.56348  17.85528  1.000 34.30365  ?  391  LEU A CA  1 
ATOM   3008 C  C   . LEU A 1 391 ? 4.32646   -6.32657  18.83993  1.000 33.93843  ?  391  LEU A C   1 
ATOM   3009 O  O   . LEU A 1 391 ? 3.15591   -6.58644  18.54595  1.000 33.86685  ?  391  LEU A O   1 
ATOM   3010 C  CB  . LEU A 1 391 ? 5.17844   -5.85255  16.53785  1.000 28.81103  ?  391  LEU A CB  1 
ATOM   3011 C  CG  . LEU A 1 391 ? 6.31951   -5.99179  15.54948  1.000 31.00050  ?  391  LEU A CG  1 
ATOM   3012 C  CD1 . LEU A 1 391 ? 6.06125   -5.14079  14.32357  1.000 33.98976  ?  391  LEU A CD1 1 
ATOM   3013 C  CD2 . LEU A 1 391 ? 7.64473   -5.64539  16.22095  1.000 32.04083  ?  391  LEU A CD2 1 
ATOM   3014 N  N   . ASP A 1 392 ? 4.68104   -5.84913  20.00822  1.000 33.92328  ?  392  ASP A N   1 
ATOM   3015 C  CA  . ASP A 1 392 ? 3.67862   -5.59150  21.01493  1.000 36.22628  ?  392  ASP A CA  1 
ATOM   3016 C  C   . ASP A 1 392 ? 3.07993   -4.22103  20.72038  1.000 34.79395  ?  392  ASP A C   1 
ATOM   3017 O  O   . ASP A 1 392 ? 3.81477   -3.25672  20.50122  1.000 36.44325  ?  392  ASP A O   1 
ATOM   3018 C  CB  . ASP A 1 392 ? 4.33672   -5.68484  22.38310  1.000 35.89211  ?  392  ASP A CB  1 
ATOM   3019 C  CG  . ASP A 1 392 ? 3.35144   -5.72552  23.50849  1.000 46.49366  ?  392  ASP A CG  1 
ATOM   3020 O  OD1 . ASP A 1 392 ? 3.78623   -6.06203  24.63591  1.000 50.06366  -1 392  ASP A OD1 1 
ATOM   3021 O  OD2 . ASP A 1 392 ? 2.16145   -5.40070  23.28674  1.000 51.34083  -1 392  ASP A OD2 1 
ATOM   3022 N  N   . GLU A 1 393 ? 1.75528   -4.16385  20.61992  1.000 36.95911  ?  393  GLU A N   1 
ATOM   3023 C  CA  . GLU A 1 393 ? 1.00733   -2.95718  20.25059  1.000 38.11302  ?  393  GLU A CA  1 
ATOM   3024 C  C   . GLU A 1 393 ? 1.60423   -2.30367  19.00683  1.000 39.79229  ?  393  GLU A C   1 
ATOM   3025 O  O   . GLU A 1 393 ? 2.08009   -1.16373  19.02916  1.000 32.98812  ?  393  GLU A O   1 
ATOM   3026 C  CB  . GLU A 1 393 ? 0.94046   -1.95496  21.41597  1.000 39.36844  ?  393  GLU A CB  1 
ATOM   3027 C  CG  . GLU A 1 393 ? 0.38941   -2.49639  22.75466  1.000 38.64834  ?  393  GLU A CG  1 
ATOM   3028 C  CD  . GLU A 1 393 ? -1.03073  -3.07717  22.65756  1.000 42.24306  ?  393  GLU A CD  1 
ATOM   3029 O  OE1 . GLU A 1 393 ? -1.74047  -2.79417  21.66268  1.000 40.00604  ?  393  GLU A OE1 1 
ATOM   3030 O  OE2 . GLU A 1 393 ? -1.43813  -3.80799  23.58794  1.000 35.65548  -1 393  GLU A OE2 1 
ATOM   3031 N  N   . ALA A 1 394 ? 1.58113   -3.05429  17.90260  1.000 37.05889  ?  394  ALA A N   1 
ATOM   3032 C  CA  . ALA A 1 394 ? 2.28387   -2.56938  16.71751  1.000 37.62861  ?  394  ALA A CA  1 
ATOM   3033 C  C   . ALA A 1 394 ? 1.65099   -1.30214  16.16702  1.000 38.99811  ?  394  ALA A C   1 
ATOM   3034 O  O   . ALA A 1 394 ? 2.35384   -0.48172  15.55652  1.000 35.95745  ?  394  ALA A O   1 
ATOM   3035 C  CB  . ALA A 1 394 ? 2.33085   -3.63735  15.63479  1.000 38.53125  ?  394  ALA A CB  1 
ATOM   3036 N  N   . GLN A 1 395 ? 0.34768   -1.10856  16.40252  1.000 34.20066  ?  395  GLN A N   1 
ATOM   3037 C  CA  . GLN A 1 395 ? -0.33077  0.07034   15.87003  1.000 38.95568  ?  395  GLN A CA  1 
ATOM   3038 C  C   . GLN A 1 395 ? 0.26520   1.36189   16.40410  1.000 36.72192  ?  395  GLN A C   1 
ATOM   3039 O  O   . GLN A 1 395 ? 0.03990   2.42557   15.82154  1.000 38.53233  ?  395  GLN A O   1 
ATOM   3040 C  CB  . GLN A 1 395 ? -1.82563  0.01312   16.17823  1.000 34.81931  ?  395  GLN A CB  1 
ATOM   3041 C  CG  . GLN A 1 395 ? -2.22858  0.33999   17.60747  1.000 31.84236  ?  395  GLN A CG  1 
ATOM   3042 C  CD  . GLN A 1 395 ? -1.90012  -0.76529  18.59341  1.000 37.88365  ?  395  GLN A CD  1 
ATOM   3043 O  OE1 . GLN A 1 395 ? -1.53241  -1.88805  18.21129  1.000 35.59817  ?  395  GLN A OE1 1 
ATOM   3044 N  NE2 . GLN A 1 395 ? -1.99163  -0.44158  19.88084  1.000 38.00166  ?  395  GLN A NE2 1 
ATOM   3045 N  N   . GLN A 1 396 ? 1.04300   1.29834   17.47947  1.000 34.91137  ?  396  GLN A N   1 
ATOM   3046 C  CA  . GLN A 1 396 ? 1.67681   2.49809   18.00164  1.000 38.82962  ?  396  GLN A CA  1 
ATOM   3047 C  C   . GLN A 1 396 ? 3.01800   2.81172   17.34452  1.000 38.60303  ?  396  GLN A C   1 
ATOM   3048 O  O   . GLN A 1 396 ? 3.65003   3.80625   17.72175  1.000 38.97935  ?  396  GLN A O   1 
ATOM   3049 C  CB  . GLN A 1 396 ? 1.84975   2.37644   19.52242  1.000 40.82328  ?  396  GLN A CB  1 
ATOM   3050 C  CG  . GLN A 1 396 ? 0.54096   2.51323   20.27234  1.000 36.47913  ?  396  GLN A CG  1 
ATOM   3051 C  CD  . GLN A 1 396 ? 0.70395   2.18644   21.73083  1.000 37.70892  ?  396  GLN A CD  1 
ATOM   3052 O  OE1 . GLN A 1 396 ? 1.76055   2.41864   22.31316  1.000 38.94303  ?  396  GLN A OE1 1 
ATOM   3053 N  NE2 . GLN A 1 396 ? -0.33982  1.64130   22.33289  1.000 46.89697  ?  396  GLN A NE2 1 
ATOM   3054 N  N   . LEU A 1 397 ? 3.47048   2.00901   16.38300  1.000 35.21163  ?  397  LEU A N   1 
ATOM   3055 C  CA  . LEU A 1 397 ? 4.64541   2.40486   15.62529  1.000 40.77306  ?  397  LEU A CA  1 
ATOM   3056 C  C   . LEU A 1 397 ? 4.42323   3.81151   15.06928  1.000 36.00140  ?  397  LEU A C   1 
ATOM   3057 O  O   . LEU A 1 397 ? 3.32695   4.10958   14.58056  1.000 34.29799  ?  397  LEU A O   1 
ATOM   3058 C  CB  . LEU A 1 397 ? 4.91048   1.42395   14.47337  1.000 38.82154  ?  397  LEU A CB  1 
ATOM   3059 C  CG  . LEU A 1 397 ? 5.47382   0.01675   14.71722  1.000 39.41837  ?  397  LEU A CG  1 
ATOM   3060 C  CD1 . LEU A 1 397 ? 4.95225   -0.95255  13.66560  1.000 37.50805  ?  397  LEU A CD1 1 
ATOM   3061 C  CD2 . LEU A 1 397 ? 6.97004   0.00622   14.72825  1.000 36.48134  ?  397  LEU A CD2 1 
ATOM   3062 N  N   . PRO A 1 398 ? 5.43405   4.71066   15.13908  1.000 42.86429  ?  398  PRO A N   1 
ATOM   3063 C  CA  . PRO A 1 398 ? 5.23626   6.10165   14.69051  1.000 41.88060  ?  398  PRO A CA  1 
ATOM   3064 C  C   . PRO A 1 398 ? 4.62158   6.19930   13.30282  1.000 39.12142  ?  398  PRO A C   1 
ATOM   3065 O  O   . PRO A 1 398 ? 5.18315   5.70319   12.31691  1.000 39.27482  ?  398  PRO A O   1 
ATOM   3066 C  CB  . PRO A 1 398 ? 6.65657   6.67623   14.70891  1.000 39.90352  ?  398  PRO A CB  1 
ATOM   3067 C  CG  . PRO A 1 398 ? 7.33489   5.91147   15.74911  1.000 37.72615  ?  398  PRO A CG  1 
ATOM   3068 C  CD  . PRO A 1 398 ? 6.81166   4.48996   15.59731  1.000 42.48475  ?  398  PRO A CD  1 
ATOM   3069 N  N   . ARG A 1 399 ? 3.45627   6.84311   13.23593  1.000 35.97050  ?  399  ARG A N   1 
ATOM   3070 C  CA  . ARG A 1 399 ? 2.67917   6.87629   12.00436  1.000 35.90955  ?  399  ARG A CA  1 
ATOM   3071 C  C   . ARG A 1 399 ? 3.48375   7.45866   10.84098  1.000 37.75217  ?  399  ARG A C   1 
ATOM   3072 O  O   . ARG A 1 399 ? 3.36376   6.99084   9.69836   1.000 35.13091  ?  399  ARG A O   1 
ATOM   3073 C  CB  . ARG A 1 399 ? 1.38695   7.65192   12.26152  1.000 40.18231  ?  399  ARG A CB  1 
ATOM   3074 C  CG  . ARG A 1 399 ? 0.53306   7.93281   11.05134  1.000 38.71861  ?  399  ARG A CG  1 
ATOM   3075 C  CD  . ARG A 1 399 ? -0.26185  6.68720   10.66821  1.000 43.60609  ?  399  ARG A CD  1 
ATOM   3076 N  NE  . ARG A 1 399 ? -1.27652  6.98343   9.66607   1.000 40.05092  ?  399  ARG A NE  1 
ATOM   3077 C  CZ  . ARG A 1 399 ? -1.81741  6.08868   8.85668   1.000 42.68395  ?  399  ARG A CZ  1 
ATOM   3078 N  NH1 . ARG A 1 399 ? -1.46683  4.80613   8.90459   1.000 44.48949  ?  399  ARG A NH1 1 
ATOM   3079 N  NH2 . ARG A 1 399 ? -2.73382  6.48426   7.98043   1.000 37.93242  ?  399  ARG A NH2 1 
ATOM   3080 N  N   . ASP A 1 400 ? 4.34319   8.45105   11.11328  1.000 37.78657  ?  400  ASP A N   1 
ATOM   3081 C  CA  . ASP A 1 400 ? 5.06227   9.11863   10.03142  1.000 37.64095  ?  400  ASP A CA  1 
ATOM   3082 C  C   . ASP A 1 400 ? 6.16674   8.25451   9.41586   1.000 41.42554  ?  400  ASP A C   1 
ATOM   3083 O  O   . ASP A 1 400 ? 6.69381   8.60395   8.35561   1.000 37.94955  ?  400  ASP A O   1 
ATOM   3084 C  CB  . ASP A 1 400 ? 5.62532   10.45532  10.52712  1.000 40.39885  ?  400  ASP A CB  1 
ATOM   3085 C  CG  . ASP A 1 400 ? 6.33320   10.34022  11.85888  1.000 51.80318  ?  400  ASP A CG  1 
ATOM   3086 O  OD1 . ASP A 1 400 ? 7.47305   10.86673  11.97182  1.000 54.28153  -1 400  ASP A OD1 1 
ATOM   3087 O  OD2 . ASP A 1 400 ? 5.75302   9.71965   12.78908  1.000 57.10297  -1 400  ASP A OD2 1 
ATOM   3088 N  N   . PHE A 1 401 ? 6.52013   7.13765   10.03693  1.000 37.65655  ?  401  PHE A N   1 
ATOM   3089 C  CA  . PHE A 1 401 ? 7.44730   6.18449   9.45824   1.000 34.32191  ?  401  PHE A CA  1 
ATOM   3090 C  C   . PHE A 1 401 ? 6.75797   4.88114   9.10706   1.000 38.24446  ?  401  PHE A C   1 
ATOM   3091 O  O   . PHE A 1 401 ? 7.44603   3.88983   8.85706   1.000 34.05453  ?  401  PHE A O   1 
ATOM   3092 C  CB  . PHE A 1 401 ? 8.59624   5.88323   10.42791  1.000 38.78120  ?  401  PHE A CB  1 
ATOM   3093 C  CG  . PHE A 1 401 ? 9.58559   7.01053   10.59062  1.000 38.47156  ?  401  PHE A CG  1 
ATOM   3094 C  CD1 . PHE A 1 401 ? 10.70373  7.08042   9.78690   1.000 36.25821  ?  401  PHE A CD1 1 
ATOM   3095 C  CD2 . PHE A 1 401 ? 9.40520   7.98253   11.57300  1.000 36.93616  ?  401  PHE A CD2 1 
ATOM   3096 C  CE1 . PHE A 1 401 ? 11.61242  8.10536   9.94467   1.000 40.62304  ?  401  PHE A CE1 1 
ATOM   3097 C  CE2 . PHE A 1 401 ? 10.31044  8.98550   11.73694  1.000 36.08495  ?  401  PHE A CE2 1 
ATOM   3098 C  CZ  . PHE A 1 401 ? 11.40463  9.06295   10.92084  1.000 39.59265  ?  401  PHE A CZ  1 
ATOM   3099 N  N   . GLN A 1 402 ? 5.41993   4.84527   9.13282   1.000 33.28192  ?  402  GLN A N   1 
ATOM   3100 C  CA  . GLN A 1 402 ? 4.72517   3.56978   8.98942   1.000 31.23889  ?  402  GLN A CA  1 
ATOM   3101 C  C   . GLN A 1 402 ? 4.88088   2.96428   7.59918   1.000 35.90552  ?  402  GLN A C   1 
ATOM   3102 O  O   . GLN A 1 402 ? 4.91447   1.72544   7.46899   1.000 31.57691  ?  402  GLN A O   1 
ATOM   3103 C  CB  . GLN A 1 402 ? 3.24554   3.73263   9.34813   1.000 33.48539  ?  402  GLN A CB  1 
ATOM   3104 C  CG  . GLN A 1 402 ? 3.04858   3.43522   10.83175  1.000 36.51235  ?  402  GLN A CG  1 
ATOM   3105 C  CD  . GLN A 1 402 ? 1.59510   3.27489   11.26473  1.000 38.97809  ?  402  GLN A CD  1 
ATOM   3106 O  OE1 . GLN A 1 402 ? 0.70808   2.95586   10.45791  1.000 34.80497  ?  402  GLN A OE1 1 
ATOM   3107 N  NE2 . GLN A 1 402 ? 1.35080   3.48457   12.56238  1.000 37.51255  ?  402  GLN A NE2 1 
ATOM   3108 N  N   . LYS A 1 403 ? 4.98361   3.79869   6.54793   1.000 31.61933  ?  403  LYS A N   1 
ATOM   3109 C  CA  . LYS A 1 403 ? 5.18426   3.23423   5.21281   1.000 35.54967  ?  403  LYS A CA  1 
ATOM   3110 C  C   . LYS A 1 403 ? 6.54033   2.54245   5.05842   1.000 35.04421  ?  403  LYS A C   1 
ATOM   3111 O  O   . LYS A 1 403 ? 6.56116   1.35749   4.66832   1.000 36.38521  ?  403  LYS A O   1 
ATOM   3112 C  CB  . LYS A 1 403 ? 4.96055   4.30960   4.14694   1.000 37.52208  ?  403  LYS A CB  1 
ATOM   3113 C  CG  . LYS A 1 403 ? 4.70893   3.74378   2.74979   1.000 39.16597  ?  403  LYS A CG  1 
ATOM   3114 C  CD  . LYS A 1 403 ? 5.63117   4.36634   1.69067   1.000 46.52540  ?  403  LYS A CD  1 
ATOM   3115 C  CE  . LYS A 1 403 ? 5.13109   4.10847   0.24626   1.000 44.93879  ?  403  LYS A CE  1 
ATOM   3116 N  NZ  . LYS A 1 403 ? 5.64413   2.80495   -0.28165  1.000 50.45397  ?  403  LYS A NZ  1 
ATOM   3117 N  N   . PRO A 1 404 ? 7.69064   3.18035   5.33815   1.000 30.77544  ?  404  PRO A N   1 
ATOM   3118 C  CA  . PRO A 1 404 ? 8.94885   2.41328   5.25722   1.000 31.99332  ?  404  PRO A CA  1 
ATOM   3119 C  C   . PRO A 1 404 ? 8.94774   1.19188   6.15740   1.000 32.85309  ?  404  PRO A C   1 
ATOM   3120 O  O   . PRO A 1 404 ? 9.34738   0.09695   5.72708   1.000 34.22170  ?  404  PRO A O   1 
ATOM   3121 C  CB  . PRO A 1 404 ? 10.02899  3.43183   5.66374   1.000 32.61935  ?  404  PRO A CB  1 
ATOM   3122 C  CG  . PRO A 1 404 ? 9.29732   4.56238   6.31480   1.000 30.44194  ?  404  PRO A CG  1 
ATOM   3123 C  CD  . PRO A 1 404 ? 7.92659   4.58912   5.72701   1.000 33.41286  ?  404  PRO A CD  1 
ATOM   3124 N  N   . ILE A 1 405 ? 8.41931   1.32266   7.37400   1.000 30.00040  ?  405  ILE A N   1 
ATOM   3125 C  CA  . ILE A 1 405 ? 8.47507   0.20144   8.30945   1.000 31.45511  ?  405  ILE A CA  1 
ATOM   3126 C  C   . ILE A 1 405 ? 7.64966   -0.97582  7.77997   1.000 31.69348  ?  405  ILE A C   1 
ATOM   3127 O  O   . ILE A 1 405 ? 8.11583   -2.13665  7.75477   1.000 29.74166  ?  405  ILE A O   1 
ATOM   3128 C  CB  . ILE A 1 405 ? 8.02975   0.67375   9.70842   1.000 31.44894  ?  405  ILE A CB  1 
ATOM   3129 C  CG1 . ILE A 1 405 ? 9.07531   1.65954   10.25103  1.000 31.11187  ?  405  ILE A CG1 1 
ATOM   3130 C  CG2 . ILE A 1 405 ? 7.79972   -0.49154  10.65107  1.000 25.03468  ?  405  ILE A CG2 1 
ATOM   3131 C  CD1 . ILE A 1 405 ? 8.80653   2.16868   11.63852  1.000 33.49598  ?  405  ILE A CD1 1 
ATOM   3132 N  N   . THR A 1 406 ? 6.43958   -0.69207  7.28378   1.000 24.64569  ?  406  THR A N   1 
ATOM   3133 C  CA  . THR A 1 406 ? 5.62647   -1.80127  6.80038   1.000 32.89335  ?  406  THR A CA  1 
ATOM   3134 C  C   . THR A 1 406 ? 6.18153   -2.33591  5.48163   1.000 38.58084  ?  406  THR A C   1 
ATOM   3135 O  O   . THR A 1 406 ? 6.12567   -3.56011  5.25294   1.000 30.76461  ?  406  THR A O   1 
ATOM   3136 C  CB  . THR A 1 406 ? 4.12503   -1.43565  6.70938   1.000 38.92707  ?  406  THR A CB  1 
ATOM   3137 O  OG1 . THR A 1 406 ? 3.89385   -0.34306  5.81962   1.000 36.34951  ?  406  THR A OG1 1 
ATOM   3138 C  CG2 . THR A 1 406 ? 3.55703   -1.05953  8.08668   1.000 32.85939  ?  406  THR A CG2 1 
ATOM   3139 N  N   . ASP A 1 407 ? 6.82627   -1.47456  4.66822   1.000 31.50663  ?  407  ASP A N   1 
ATOM   3140 C  CA  . ASP A 1 407 ? 7.51301   -2.00500  3.49341   1.000 32.49879  ?  407  ASP A CA  1 
ATOM   3141 C  C   . ASP A 1 407 ? 8.59636   -2.97289  3.94247   1.000 35.75520  ?  407  ASP A C   1 
ATOM   3142 O  O   . ASP A 1 407 ? 8.66045   -4.12013  3.47349   1.000 32.97295  ?  407  ASP A O   1 
ATOM   3143 C  CB  . ASP A 1 407 ? 8.11221   -0.88188  2.63698   1.000 35.32950  ?  407  ASP A CB  1 
ATOM   3144 C  CG  . ASP A 1 407 ? 7.05293   -0.10550  1.84101   1.000 38.75053  ?  407  ASP A CG  1 
ATOM   3145 O  OD1 . ASP A 1 407 ? 5.91268   -0.58304  1.72658   1.000 40.60189  ?  407  ASP A OD1 1 
ATOM   3146 O  OD2 . ASP A 1 407 ? 7.35451   0.99182   1.32941   1.000 44.75719  -1 407  ASP A OD2 1 
ATOM   3147 N  N   . MET A 1 408 ? 9.38081   -2.55309  4.94375   1.000 31.31431  ?  408  MET A N   1 
ATOM   3148 C  CA  . MET A 1 408 ? 10.39892  -3.41517  5.53448   1.000 33.46027  ?  408  MET A CA  1 
ATOM   3149 C  C   . MET A 1 408 ? 9.78446   -4.73924  5.93866   1.000 30.69943  ?  408  MET A C   1 
ATOM   3150 O  O   . MET A 1 408 ? 10.25712  -5.80967  5.53313   1.000 36.00505  ?  408  MET A O   1 
ATOM   3151 C  CB  . MET A 1 408 ? 10.99429  -2.72557  6.76136   1.000 28.19116  ?  408  MET A CB  1 
ATOM   3152 C  CG  . MET A 1 408 ? 12.28187  -3.26352  7.36556   1.000 31.69892  ?  408  MET A CG  1 
ATOM   3153 S  SD  . MET A 1 408 ? 13.62128  -3.93436  6.33647   1.000 30.04748  ?  408  MET A SD  1 
ATOM   3154 C  CE  . MET A 1 408 ? 14.46218  -2.38196  6.10929   1.000 27.85192  ?  408  MET A CE  1 
ATOM   3155 N  N   . MET A 1 409 ? 8.67666   -4.67330  6.67633   1.000 29.05483  ?  409  MET A N   1 
ATOM   3156 C  CA  . MET A 1 409 ? 8.11657   -5.89575  7.23005   1.000 31.12281  ?  409  MET A CA  1 
ATOM   3157 C  C   . MET A 1 409 ? 7.64983   -6.80236  6.10076   1.000 32.22999  ?  409  MET A C   1 
ATOM   3158 O  O   . MET A 1 409 ? 7.97119   -8.00558  6.07560   1.000 30.32371  ?  409  MET A O   1 
ATOM   3159 C  CB  . MET A 1 409 ? 6.97826   -5.55592  8.19770   1.000 29.51434  ?  409  MET A CB  1 
ATOM   3160 C  CG  . MET A 1 409 ? 7.40565   -4.99286  9.55901   1.000 26.53412  ?  409  MET A CG  1 
ATOM   3161 S  SD  . MET A 1 409 ? 5.97124   -4.20351  10.36713  1.000 26.95872  ?  409  MET A SD  1 
ATOM   3162 C  CE  . MET A 1 409 ? 5.00154   -5.70603  10.75129  1.000 25.00205  ?  409  MET A CE  1 
ATOM   3163 N  N   . ARG A 1 410 ? 7.02947   -6.20021  5.07844   1.000 28.44428  ?  410  ARG A N   1 
ATOM   3164 C  CA  . ARG A 1 410 ? 6.56649   -6.98709  3.94899   1.000 37.12686  ?  410  ARG A CA  1 
ATOM   3165 C  C   . ARG A 1 410 ? 7.72516   -7.76647  3.35476   1.000 35.06371  ?  410  ARG A C   1 
ATOM   3166 O  O   . ARG A 1 410 ? 7.67796   -9.00414  3.25846   1.000 31.06908  ?  410  ARG A O   1 
ATOM   3167 C  CB  . ARG A 1 410 ? 5.91845   -6.07368  2.91153   1.000 36.71380  ?  410  ARG A CB  1 
ATOM   3168 C  CG  . ARG A 1 410 ? 4.99759   -6.79378  1.94461   1.000 44.09906  ?  410  ARG A CG  1 
ATOM   3169 C  CD  . ARG A 1 410 ? 3.95252   -5.81961  1.41689   1.000 52.63186  ?  410  ARG A CD  1 
ATOM   3170 N  NE  . ARG A 1 410 ? 4.59021   -4.62171  0.88562   1.000 42.59906  ?  410  ARG A NE  1 
ATOM   3171 C  CZ  . ARG A 1 410 ? 4.36108   -3.38480  1.31251   1.000 50.46646  ?  410  ARG A CZ  1 
ATOM   3172 N  NH1 . ARG A 1 410 ? 3.49499   -3.13214  2.29086   1.000 45.93473  ?  410  ARG A NH1 1 
ATOM   3173 N  NH2 . ARG A 1 410 ? 5.00342   -2.37238  0.73031   1.000 43.81335  ?  410  ARG A NH2 1 
ATOM   3174 N  N   . VAL A 1 411 ? 8.83287   -7.06809  3.08502   1.000 30.16837  ?  411  VAL A N   1 
ATOM   3175 C  CA  . VAL A 1 411 ? 9.95407   -7.73898  2.44632   1.000 29.98304  ?  411  VAL A CA  1 
ATOM   3176 C  C   . VAL A 1 411 ? 10.50060  -8.82790  3.35828   1.000 31.82285  ?  411  VAL A C   1 
ATOM   3177 O  O   . VAL A 1 411 ? 10.76030  -9.95621  2.91843   1.000 34.83240  ?  411  VAL A O   1 
ATOM   3178 C  CB  . VAL A 1 411 ? 11.04116  -6.72345  2.05536   1.000 35.44136  ?  411  VAL A CB  1 
ATOM   3179 C  CG1 . VAL A 1 411 ? 12.24011  -7.48001  1.52223   1.000 37.35133  ?  411  VAL A CG1 1 
ATOM   3180 C  CG2 . VAL A 1 411 ? 10.50800  -5.71591  1.01380   1.000 28.31280  ?  411  VAL A CG2 1 
ATOM   3181 N  N   . LEU A 1 412 ? 10.64366  -8.52557  4.65053   1.000 29.11075  ?  412  LEU A N   1 
ATOM   3182 C  CA  . LEU A 1 412 ? 11.26311  -9.49690  5.54065   1.000 29.81986  ?  412  LEU A CA  1 
ATOM   3183 C  C   . LEU A 1 412 ? 10.37433  -10.72931 5.67169   1.000 33.38142  ?  412  LEU A C   1 
ATOM   3184 O  O   . LEU A 1 412 ? 10.86918  -11.86039 5.76965   1.000 30.81309  ?  412  LEU A O   1 
ATOM   3185 C  CB  . LEU A 1 412 ? 11.53333  -8.86742  6.91708   1.000 27.31204  ?  412  LEU A CB  1 
ATOM   3186 C  CG  . LEU A 1 412 ? 12.70307  -7.87308  7.10104   1.000 28.04874  ?  412  LEU A CG  1 
ATOM   3187 C  CD1 . LEU A 1 412 ? 12.60881  -7.12421  8.41400   1.000 25.82193  ?  412  LEU A CD1 1 
ATOM   3188 C  CD2 . LEU A 1 412 ? 14.04000  -8.57750  7.05566   1.000 33.39962  ?  412  LEU A CD2 1 
ATOM   3189 N  N   . ALA A 1 413 ? 9.05678   -10.53719 5.64177   1.000 28.18932  ?  413  ALA A N   1 
ATOM   3190 C  CA  . ALA A 1 413 ? 8.20828   -11.70312 5.78062   1.000 30.32625  ?  413  ALA A CA  1 
ATOM   3191 C  C   . ALA A 1 413 ? 8.22775   -12.52317 4.50573   1.000 32.62105  ?  413  ALA A C   1 
ATOM   3192 O  O   . ALA A 1 413 ? 8.11497   -13.74920 4.56114   1.000 31.88150  ?  413  ALA A O   1 
ATOM   3193 C  CB  . ALA A 1 413 ? 6.78060   -11.29474 6.15617   1.000 28.40276  ?  413  ALA A CB  1 
ATOM   3194 N  N   . ARG A 1 414 ? 8.43924   -11.87699 3.35431   1.000 36.19102  ?  414  ARG A N   1 
ATOM   3195 C  CA  . ARG A 1 414 ? 8.24640   -12.61141 2.11044   1.000 33.00632  ?  414  ARG A CA  1 
ATOM   3196 C  C   . ARG A 1 414 ? 9.53008   -13.28249 1.66086   1.000 39.95572  ?  414  ARG A C   1 
ATOM   3197 O  O   . ARG A 1 414 ? 9.51662   -14.45600 1.25651   1.000 35.80540  ?  414  ARG A O   1 
ATOM   3198 C  CB  . ARG A 1 414 ? 7.71202   -11.67026 1.03538   1.000 36.00148  ?  414  ARG A CB  1 
ATOM   3199 C  CG  . ARG A 1 414 ? 7.27695   -12.34850 -0.25452  1.000 40.40244  ?  414  ARG A CG  1 
ATOM   3200 C  CD  . ARG A 1 414 ? 6.95165   -11.30355 -1.33315  1.000 40.20896  ?  414  ARG A CD  1 
ATOM   3201 N  NE  . ARG A 1 414 ? 8.13421   -10.50564 -1.63006  1.000 45.75317  ?  414  ARG A NE  1 
ATOM   3202 C  CZ  . ARG A 1 414 ? 8.14543   -9.18344  -1.76182  1.000 48.05366  ?  414  ARG A CZ  1 
ATOM   3203 N  NH1 . ARG A 1 414 ? 7.02829   -8.46783  -1.70010  1.000 44.45205  ?  414  ARG A NH1 1 
ATOM   3204 N  NH2 . ARG A 1 414 ? 9.30940   -8.56082  -1.94791  1.000 38.52059  ?  414  ARG A NH2 1 
ATOM   3205 N  N   . ASP A 1 415 ? 10.65583  -12.57804 1.80113   1.000 34.56045  ?  415  ASP A N   1 
ATOM   3206 C  CA  . ASP A 1 415 ? 11.91021  -13.01432 1.22437   1.000 33.92314  ?  415  ASP A CA  1 
ATOM   3207 C  C   . ASP A 1 415 ? 12.96310  -13.44432 2.23937   1.000 33.21374  ?  415  ASP A C   1 
ATOM   3208 O  O   . ASP A 1 415 ? 13.92208  -14.10485 1.85133   1.000 37.58323  ?  415  ASP A O   1 
ATOM   3209 C  CB  . ASP A 1 415 ? 12.45917  -11.89390 0.33306   1.000 33.80302  ?  415  ASP A CB  1 
ATOM   3210 C  CG  . ASP A 1 415 ? 11.45120  -11.46364 -0.72185  1.000 39.43903  ?  415  ASP A CG  1 
ATOM   3211 O  OD1 . ASP A 1 415 ? 10.67165  -12.32614 -1.16328  1.000 41.87518  ?  415  ASP A OD1 1 
ATOM   3212 O  OD2 . ASP A 1 415 ? 11.39735  -10.26621 -1.09475  1.000 41.99444  -1 415  ASP A OD2 1 
ATOM   3213 N  N   . TYR A 1 416 ? 12.81154  -13.12592 3.52532   1.000 31.56270  ?  416  TYR A N   1 
ATOM   3214 C  CA  . TYR A 1 416 ? 13.86137  -13.43661 4.48955   1.000 29.55220  ?  416  TYR A CA  1 
ATOM   3215 C  C   . TYR A 1 416 ? 13.37909  -14.32241 5.63189   1.000 29.75404  ?  416  TYR A C   1 
ATOM   3216 O  O   . TYR A 1 416 ? 13.99617  -14.30782 6.70755   1.000 28.93877  ?  416  TYR A O   1 
ATOM   3217 C  CB  . TYR A 1 416 ? 14.48184  -12.14920 5.06447   1.000 26.02152  ?  416  TYR A CB  1 
ATOM   3218 C  CG  . TYR A 1 416 ? 15.20009  -11.32370 4.03919   1.000 31.11985  ?  416  TYR A CG  1 
ATOM   3219 C  CD1 . TYR A 1 416 ? 14.50316  -10.43928 3.23908   1.000 32.83704  ?  416  TYR A CD1 1 
ATOM   3220 C  CD2 . TYR A 1 416 ? 16.57357  -11.44180 3.85023   1.000 32.09477  ?  416  TYR A CD2 1 
ATOM   3221 C  CE1 . TYR A 1 416 ? 15.14562  -9.67910  2.28742   1.000 36.34178  ?  416  TYR A CE1 1 
ATOM   3222 C  CE2 . TYR A 1 416 ? 17.23861  -10.67359 2.88149   1.000 31.88583  ?  416  TYR A CE2 1 
ATOM   3223 C  CZ  . TYR A 1 416 ? 16.50487  -9.79444  2.10764   1.000 34.73630  ?  416  TYR A CZ  1 
ATOM   3224 O  OH  . TYR A 1 416 ? 17.09747  -9.00793  1.13790   1.000 33.30811  ?  416  TYR A OH  1 
ATOM   3225 N  N   . GLY A 1 417 ? 12.28147  -15.06293 5.44392   1.000 31.13765  ?  417  GLY A N   1 
ATOM   3226 C  CA  . GLY A 1 417 ? 11.88406  -16.06761 6.42434   1.000 28.32094  ?  417  GLY A CA  1 
ATOM   3227 C  C   . GLY A 1 417 ? 11.37930  -15.55058 7.76485   1.000 32.79859  ?  417  GLY A C   1 
ATOM   3228 O  O   . GLY A 1 417 ? 11.35820  -16.30990 8.74294   1.000 26.60213  ?  417  GLY A O   1 
ATOM   3229 N  N   . VAL A 1 418 ? 10.96317  -14.27405 7.85393   1.000 28.17533  ?  418  VAL A N   1 
ATOM   3230 C  CA  . VAL A 1 418 ? 10.59829  -13.70611 9.14913   1.000 27.24136  ?  418  VAL A CA  1 
ATOM   3231 C  C   . VAL A 1 418 ? 9.11385   -13.90414 9.36740   1.000 26.43418  ?  418  VAL A C   1 
ATOM   3232 O  O   . VAL A 1 418 ? 8.31452   -13.76745 8.43377   1.000 35.11412  ?  418  VAL A O   1 
ATOM   3233 C  CB  . VAL A 1 418 ? 10.99840  -12.21136 9.24246   1.000 30.51399  ?  418  VAL A CB  1 
ATOM   3234 C  CG1 . VAL A 1 418 ? 10.61124  -11.61210 10.60188  1.000 26.76144  ?  418  VAL A CG1 1 
ATOM   3235 C  CG2 . VAL A 1 418 ? 12.48600  -12.07610 9.07442   1.000 27.83569  ?  418  VAL A CG2 1 
ATOM   3236 N  N   . THR A 1 419 ? 8.73157   -14.22912 10.59929  1.000 26.48377  ?  419  THR A N   1 
ATOM   3237 C  CA  . THR A 1 419 ? 7.32760   -14.28484 10.97563  1.000 29.76924  ?  419  THR A CA  1 
ATOM   3238 C  C   . THR A 1 419 ? 7.01212   -13.12970 11.91907  1.000 29.93342  ?  419  THR A C   1 
ATOM   3239 O  O   . THR A 1 419 ? 7.65435   -12.99112 12.95185  1.000 30.05434  ?  419  THR A O   1 
ATOM   3240 C  CB  . THR A 1 419 ? 6.98048   -15.60094 11.67411  1.000 36.60801  ?  419  THR A CB  1 
ATOM   3241 O  OG1 . THR A 1 419 ? 7.10273   -16.70201 10.75720  1.000 36.44113  ?  419  THR A OG1 1 
ATOM   3242 C  CG2 . THR A 1 419 ? 5.54401   -15.52381 12.19334  1.000 33.13065  ?  419  THR A CG2 1 
ATOM   3243 N  N   . PHE A 1 420 ? 5.99966   -12.33665 11.60157  1.000 31.37366  ?  420  PHE A N   1 
ATOM   3244 C  CA  . PHE A 1 420 ? 5.58305   -11.25224 12.48733  1.000 31.94908  ?  420  PHE A CA  1 
ATOM   3245 C  C   . PHE A 1 420 ? 4.28850   -11.63891 13.19573  1.000 29.70555  ?  420  PHE A C   1 
ATOM   3246 O  O   . PHE A 1 420 ? 3.36066   -12.15472 12.56690  1.000 30.06875  ?  420  PHE A O   1 
ATOM   3247 C  CB  . PHE A 1 420 ? 5.39646   -9.94698  11.70927  1.000 28.14563  ?  420  PHE A CB  1 
ATOM   3248 C  CG  . PHE A 1 420 ? 6.69209   -9.37595  11.17943  1.000 25.63382  ?  420  PHE A CG  1 
ATOM   3249 C  CD1 . PHE A 1 420 ? 7.50013   -8.58679  11.98673  1.000 23.21001  ?  420  PHE A CD1 1 
ATOM   3250 C  CD2 . PHE A 1 420 ? 7.09397   -9.63158  9.87572   1.000 26.27323  ?  420  PHE A CD2 1 
ATOM   3251 C  CE1 . PHE A 1 420 ? 8.69005   -8.05807  11.50307  1.000 23.42143  ?  420  PHE A CE1 1 
ATOM   3252 C  CE2 . PHE A 1 420 ? 8.29997   -9.11915  9.38033   1.000 29.03183  ?  420  PHE A CE2 1 
ATOM   3253 C  CZ  . PHE A 1 420 ? 9.08830   -8.32565  10.18871  1.000 27.49260  ?  420  PHE A CZ  1 
ATOM   3254 N  N   . VAL A 1 421 ? 4.25090   -11.42610 14.50595  1.000 26.62303  ?  421  VAL A N   1 
ATOM   3255 C  CA  . VAL A 1 421 ? 3.04631   -11.57736 15.30530  1.000 26.27775  ?  421  VAL A CA  1 
ATOM   3256 C  C   . VAL A 1 421 ? 2.71191   -10.21019 15.88842  1.000 27.96670  ?  421  VAL A C   1 
ATOM   3257 O  O   . VAL A 1 421 ? 3.42538   -9.71788  16.76763  1.000 29.22516  ?  421  VAL A O   1 
ATOM   3258 C  CB  . VAL A 1 421 ? 3.21904   -12.59923 16.42943  1.000 27.54579  ?  421  VAL A CB  1 
ATOM   3259 C  CG1 . VAL A 1 421 ? 1.83485   -12.96507 16.99544  1.000 30.81116  ?  421  VAL A CG1 1 
ATOM   3260 C  CG2 . VAL A 1 421 ? 3.95127   -13.82612 15.92191  1.000 33.17867  ?  421  VAL A CG2 1 
ATOM   3261 N  N   . LEU A 1 422 ? 1.62662   -9.60832  15.42998  1.000 28.37705  ?  422  LEU A N   1 
ATOM   3262 C  CA  . LEU A 1 422 ? 1.19997   -8.28860  15.92626  1.000 30.29845  ?  422  LEU A CA  1 
ATOM   3263 C  C   . LEU A 1 422 ? 0.28491   -8.47494  17.13887  1.000 32.08529  ?  422  LEU A C   1 
ATOM   3264 O  O   . LEU A 1 422 ? -0.89893  -8.78799  16.99114  1.000 30.01321  ?  422  LEU A O   1 
ATOM   3265 C  CB  . LEU A 1 422 ? 0.50589   -7.51672  14.81673  1.000 24.16515  ?  422  LEU A CB  1 
ATOM   3266 C  CG  . LEU A 1 422 ? 1.16266   -7.60602  13.42709  1.000 26.22448  ?  422  LEU A CG  1 
ATOM   3267 C  CD1 . LEU A 1 422 ? 0.36529   -6.78079  12.44169  1.000 33.21346  ?  422  LEU A CD1 1 
ATOM   3268 C  CD2 . LEU A 1 422 ? 2.57547   -7.11220  13.45928  1.000 25.69077  ?  422  LEU A CD2 1 
ATOM   3269 N  N   . CYS A 1 423 ? 0.84422   -8.33896  18.34707  1.000 32.38661  ?  423  CYS A N   1 
ATOM   3270 C  CA  . CYS A 1 423 ? 0.08146   -8.50904  19.58510  1.000 31.51176  ?  423  CYS A CA  1 
ATOM   3271 C  C   . CYS A 1 423 ? -0.54550  -7.19248  19.97742  1.000 34.28072  ?  423  CYS A C   1 
ATOM   3272 O  O   . CYS A 1 423 ? 0.14021   -6.16738  19.99989  1.000 40.19573  ?  423  CYS A O   1 
ATOM   3273 C  CB  . CYS A 1 423 ? 0.97186   -8.95659  20.74029  1.000 39.87957  ?  423  CYS A CB  1 
ATOM   3274 S  SG  . CYS A 1 423 ? 1.52760   -10.62536 20.63097  1.000 53.07458  ?  423  CYS A SG  1 
ATOM   3275 N  N   . THR A 1 424 ? -1.82732  -7.21846  20.31824  1.000 32.89541  ?  424  THR A N   1 
ATOM   3276 C  CA  . THR A 1 424 ? -2.43574  -6.03630  20.90567  1.000 34.05844  ?  424  THR A CA  1 
ATOM   3277 C  C   . THR A 1 424 ? -3.48262  -6.45495  21.92632  1.000 39.65566  ?  424  THR A C   1 
ATOM   3278 O  O   . THR A 1 424 ? -4.25419  -7.39917  21.70444  1.000 38.33452  ?  424  THR A O   1 
ATOM   3279 C  CB  . THR A 1 424 ? -3.04940  -5.12793  19.82594  1.000 33.15675  ?  424  THR A CB  1 
ATOM   3280 O  OG1 . THR A 1 424 ? -3.63820  -3.97709  20.43747  1.000 38.16279  ?  424  THR A OG1 1 
ATOM   3281 C  CG2 . THR A 1 424 ? -4.11291  -5.86116  19.00855  1.000 37.14029  ?  424  THR A CG2 1 
ATOM   3282 N  N   . ALA A 1 425 ? -3.53960  -5.72030  23.02998  1.000 36.90930  ?  425  ALA A N   1 
ATOM   3283 C  CA  . ALA A 1 425 ? -4.56467  -5.99691  24.03004  1.000 38.33295  ?  425  ALA A CA  1 
ATOM   3284 C  C   . ALA A 1 425 ? -5.83450  -5.19170  23.77835  1.000 39.84948  ?  425  ALA A C   1 
ATOM   3285 O  O   . ALA A 1 425 ? -6.47088  -4.73186  24.72713  1.000 45.50275  ?  425  ALA A O   1 
ATOM   3286 C  CB  . ALA A 1 425 ? -4.02366  -5.74129  25.43372  1.000 39.92172  ?  425  ALA A CB  1 
ATOM   3287 N  N   . THR A 1 426 ? -6.21485  -4.96456  22.51976  1.000 35.94811  ?  426  THR A N   1 
ATOM   3288 C  CA  . THR A 1 426 ? -7.41913  -4.19665  22.19141  1.000 41.42192  ?  426  THR A CA  1 
ATOM   3289 C  C   . THR A 1 426 ? -8.60444  -5.07235  21.75732  1.000 45.69947  ?  426  THR A C   1 
ATOM   3290 O  O   . THR A 1 426 ? -9.38920  -4.67274  20.87647  1.000 37.42452  ?  426  THR A O   1 
ATOM   3291 C  CB  . THR A 1 426 ? -7.09964  -3.16207  21.11574  1.000 38.49701  ?  426  THR A CB  1 
ATOM   3292 O  OG1 . THR A 1 426 ? -6.23275  -3.75182  20.14349  1.000 43.48848  ?  426  THR A OG1 1 
ATOM   3293 C  CG2 . THR A 1 426 ? -6.39131  -1.98162  21.72904  1.000 37.33716  ?  426  THR A CG2 1 
ATOM   3294 N  N   . GLN A 1 427 ? -8.79016  -6.25188  22.36476  1.000 39.77293  ?  427  GLN A N   1 
ATOM   3295 C  CA  . GLN A 1 427 ? -10.03814 -6.98836  22.15547  1.000 39.48873  ?  427  GLN A CA  1 
ATOM   3296 C  C   . GLN A 1 427 ? -11.18745 -6.24547  22.82276  1.000 38.66119  ?  427  GLN A C   1 
ATOM   3297 O  O   . GLN A 1 427 ? -11.13227 -5.99241  24.03262  1.000 40.97112  ?  427  GLN A O   1 
ATOM   3298 C  CB  . GLN A 1 427 ? -9.96647  -8.41864  22.69513  1.000 36.43920  ?  427  GLN A CB  1 
ATOM   3299 C  CG  . GLN A 1 427 ? -11.11588 -9.27065  22.20553  1.000 42.73852  ?  427  GLN A CG  1 
ATOM   3300 C  CD  . GLN A 1 427 ? -10.64146 -10.58562 21.61310  1.000 55.52268  ?  427  GLN A CD  1 
ATOM   3301 O  OE1 . GLN A 1 427 ? -10.04120 -10.63078 20.52767  1.000 57.54910  ?  427  GLN A OE1 1 
ATOM   3302 N  NE2 . GLN A 1 427 ? -10.87993 -11.66699 22.34403  1.000 50.06015  ?  427  GLN A NE2 1 
ATOM   3303 N  N   . PRO A 1 428 ? -12.23491 -5.88477  22.09011  1.000 41.18760  ?  428  PRO A N   1 
ATOM   3304 C  CA  . PRO A 1 428 ? -13.30448 -5.06862  22.67656  1.000 42.50996  ?  428  PRO A CA  1 
ATOM   3305 C  C   . PRO A 1 428 ? -14.11985 -5.82410  23.71411  1.000 46.00532  ?  428  PRO A C   1 
ATOM   3306 O  O   . PRO A 1 428 ? -14.21766 -7.05748  23.71243  1.000 38.56396  ?  428  PRO A O   1 
ATOM   3307 C  CB  . PRO A 1 428 ? -14.17385 -4.68830  21.46956  1.000 39.93146  ?  428  PRO A CB  1 
ATOM   3308 C  CG  . PRO A 1 428 ? -13.77545 -5.59185  20.38014  1.000 44.60918  ?  428  PRO A CG  1 
ATOM   3309 C  CD  . PRO A 1 428 ? -12.40004 -6.08892  20.64121  1.000 40.65303  ?  428  PRO A CD  1 
ATOM   3310 N  N   . GLU A 1 429 ? -14.72198 -5.04293  24.60900  1.000 43.58570  ?  429  GLU A N   1 
ATOM   3311 C  CA  . GLU A 1 429 ? -15.70460 -5.58059  25.53610  1.000 47.93587  ?  429  GLU A CA  1 
ATOM   3312 C  C   . GLU A 1 429 ? -17.00636 -5.86248  24.79740  1.000 50.08424  ?  429  GLU A C   1 
ATOM   3313 O  O   . GLU A 1 429 ? -17.58768 -4.95900  24.19077  1.000 50.16863  ?  429  GLU A O   1 
ATOM   3314 C  CB  . GLU A 1 429 ? -15.94453 -4.59155  26.66567  1.000 53.38482  ?  429  GLU A CB  1 
ATOM   3315 C  CG  . GLU A 1 429 ? -14.71322 -4.30309  27.48566  1.000 57.45771  ?  429  GLU A CG  1 
ATOM   3316 C  CD  . GLU A 1 429 ? -14.68515 -5.08947  28.77661  1.000 61.22318  ?  429  GLU A CD  1 
ATOM   3317 O  OE1 . GLU A 1 429 ? -13.56376 -5.36566  29.27520  1.000 63.74451  ?  429  GLU A OE1 1 
ATOM   3318 O  OE2 . GLU A 1 429 ? -15.78392 -5.43723  29.28154  1.000 64.24111  -1 429  GLU A OE2 1 
ATOM   3319 N  N   . LEU A 1 430 ? -17.47074 -7.10160  24.85110  1.000 48.19229  ?  430  LEU A N   1 
ATOM   3320 C  CA  . LEU A 1 430 ? -18.75374 -7.45575  24.24097  1.000 53.48473  ?  430  LEU A CA  1 
ATOM   3321 C  C   . LEU A 1 430 ? -19.92967 -7.14812  25.17984  1.000 56.70688  ?  430  LEU A C   1 
ATOM   3322 O  O   . LEU A 1 430 ? -20.40453 -8.02372  25.91892  1.000 58.89685  ?  430  LEU A O   1 
ATOM   3323 C  CB  . LEU A 1 430 ? -18.76349 -8.93923  23.84491  1.000 51.94876  ?  430  LEU A CB  1 
ATOM   3324 C  CG  . LEU A 1 430 ? -17.51050 -9.46278  23.12570  1.000 55.81070  ?  430  LEU A CG  1 
ATOM   3325 C  CD1 . LEU A 1 430 ? -17.59232 -10.96822 22.86373  1.000 56.82189  ?  430  LEU A CD1 1 
ATOM   3326 C  CD2 . LEU A 1 430 ? -17.23872 -8.70124  21.82306  1.000 47.89473  ?  430  LEU A CD2 1 
ATOM   3327 N  N   . ILE A 1 434 ? -21.07965 -5.43368  17.78882  1.000 51.38500  ?  434  ILE A N   1 
ATOM   3328 C  CA  . ILE A 1 434 ? -21.40978 -6.67564  18.48919  1.000 63.97281  ?  434  ILE A CA  1 
ATOM   3329 C  C   . ILE A 1 434 ? -20.36055 -7.69036  18.06273  1.000 60.45639  ?  434  ILE A C   1 
ATOM   3330 O  O   . ILE A 1 434 ? -20.60276 -8.89359  17.95822  1.000 63.60861  ?  434  ILE A O   1 
ATOM   3331 C  CB  . ILE A 1 434 ? -22.87537 -7.15091  18.21139  1.000 68.47786  ?  434  ILE A CB  1 
ATOM   3332 C  CG1 . ILE A 1 434 ? -23.33312 -8.13043  19.30319  1.000 69.71098  ?  434  ILE A CG1 1 
ATOM   3333 C  CG2 . ILE A 1 434 ? -23.06103 -7.70979  16.76561  1.000 55.46842  ?  434  ILE A CG2 1 
ATOM   3334 C  CD1 . ILE A 1 434 ? -23.09911 -7.62295  20.72500  1.000 66.23361  ?  434  ILE A CD1 1 
ATOM   3335 N  N   . ASP A 1 435 ? -19.16067 -7.14582  17.87806  1.000 63.58343  ?  435  ASP A N   1 
ATOM   3336 C  CA  . ASP A 1 435 ? -18.04422 -7.81552  17.21655  1.000 57.33357  ?  435  ASP A CA  1 
ATOM   3337 C  C   . ASP A 1 435 ? -18.42576 -8.25772  15.80897  1.000 52.11252  ?  435  ASP A C   1 
ATOM   3338 O  O   . ASP A 1 435 ? -18.13156 -9.37346  15.38975  1.000 57.07314  ?  435  ASP A O   1 
ATOM   3339 C  CB  . ASP A 1 435 ? -17.50787 -8.98945  18.03612  1.000 61.83385  ?  435  ASP A CB  1 
ATOM   3340 C  CG  . ASP A 1 435 ? -15.98624 -9.05283  18.01190  1.000 68.08506  ?  435  ASP A CG  1 
ATOM   3341 O  OD1 . ASP A 1 435 ? -15.40558 -10.05125 18.49396  1.000 70.30396  -1 435  ASP A OD1 1 
ATOM   3342 O  OD2 . ASP A 1 435 ? -15.37129 -8.07739  17.51012  1.000 66.89774  ?  435  ASP A OD2 1 
ATOM   3343 N  N   . ALA A 1 436 ? -19.07677 -7.36823  15.07527  1.000 47.60624  ?  436  ALA A N   1 
ATOM   3344 C  CA  . ALA A 1 436 ? -19.30571 -7.53843  13.65118  1.000 47.84500  ?  436  ALA A CA  1 
ATOM   3345 C  C   . ALA A 1 436 ? -18.20847 -6.91566  12.79538  1.000 44.61973  ?  436  ALA A C   1 
ATOM   3346 O  O   . ALA A 1 436 ? -18.27243 -7.01480  11.56596  1.000 46.39160  ?  436  ALA A O   1 
ATOM   3347 C  CB  . ALA A 1 436 ? -20.65268 -6.93253  13.25515  1.000 49.99144  ?  436  ALA A CB  1 
ATOM   3348 N  N   . PHE A 1 437 ? -17.21322 -6.27188  13.39849  1.000 41.21897  ?  437  PHE A N   1 
ATOM   3349 C  CA  . PHE A 1 437 ? -16.14878 -5.62452  12.64309  1.000 43.33676  ?  437  PHE A CA  1 
ATOM   3350 C  C   . PHE A 1 437 ? -14.79825 -6.27373  12.91111  1.000 42.61456  ?  437  PHE A C   1 
ATOM   3351 O  O   . PHE A 1 437 ? -14.47896 -6.63706  14.04786  1.000 46.09372  ?  437  PHE A O   1 
ATOM   3352 C  CB  . PHE A 1 437 ? -16.06803 -4.13341  12.96570  1.000 44.36876  ?  437  PHE A CB  1 
ATOM   3353 C  CG  . PHE A 1 437 ? -17.40083 -3.49870  13.14230  1.000 42.84746  ?  437  PHE A CG  1 
ATOM   3354 C  CD1 . PHE A 1 437 ? -18.15140 -3.12948  12.04090  1.000 42.85283  ?  437  PHE A CD1 1 
ATOM   3355 C  CD2 . PHE A 1 437 ? -17.92224 -3.31106  14.41103  1.000 40.76439  ?  437  PHE A CD2 1 
ATOM   3356 C  CE1 . PHE A 1 437 ? -19.39394 -2.55359  12.18656  1.000 45.43323  ?  437  PHE A CE1 1 
ATOM   3357 C  CE2 . PHE A 1 437 ? -19.16515 -2.74846  14.57615  1.000 48.93549  ?  437  PHE A CE2 1 
ATOM   3358 C  CZ  . PHE A 1 437 ? -19.90994 -2.35831  13.45596  1.000 47.24269  ?  437  PHE A CZ  1 
ATOM   3359 N  N   . GLY A 1 438 ? -14.02885 -6.43894  11.84084  1.000 45.31273  ?  438  GLY A N   1 
ATOM   3360 C  CA  . GLY A 1 438 ? -12.60027 -6.59403  11.95843  1.000 43.69714  ?  438  GLY A CA  1 
ATOM   3361 C  C   . GLY A 1 438 ? -11.90844 -5.25017  12.08783  1.000 42.52948  ?  438  GLY A C   1 
ATOM   3362 O  O   . GLY A 1 438 ? -12.50243 -4.17033  12.00640  1.000 46.46176  ?  438  GLY A O   1 
ATOM   3363 N  N   . ARG A 1 439 ? -10.61822 -5.32229  12.32456  1.000 45.72481  ?  439  ARG A N   1 
ATOM   3364 C  CA  . ARG A 1 439 ? -9.77562  -4.14852  12.39368  1.000 37.39339  ?  439  ARG A CA  1 
ATOM   3365 C  C   . ARG A 1 439 ? -8.55826  -4.40200  11.52929  1.000 44.47776  ?  439  ARG A C   1 
ATOM   3366 O  O   . ARG A 1 439 ? -8.12242  -5.54776  11.36090  1.000 45.03584  ?  439  ARG A O   1 
ATOM   3367 C  CB  . ARG A 1 439 ? -9.33245  -3.85310  13.83546  1.000 44.87684  ?  439  ARG A CB  1 
ATOM   3368 C  CG  . ARG A 1 439 ? -10.40729 -3.25986  14.73192  1.000 47.68326  ?  439  ARG A CG  1 
ATOM   3369 C  CD  . ARG A 1 439 ? -9.92546  -3.21631  16.20136  1.000 51.77113  ?  439  ARG A CD  1 
ATOM   3370 N  NE  . ARG A 1 439 ? -10.01870 -4.46604  16.95333  1.000 52.51868  ?  439  ARG A NE  1 
ATOM   3371 C  CZ  . ARG A 1 439 ? -11.10705 -5.22649  17.05886  1.000 58.40311  ?  439  ARG A CZ  1 
ATOM   3372 N  NH1 . ARG A 1 439 ? -12.27035 -4.85834  16.54389  1.000 52.86444  ?  439  ARG A NH1 1 
ATOM   3373 N  NH2 . ARG A 1 439 ? -11.03113 -6.38550  17.71451  1.000 55.83529  ?  439  ARG A NH2 1 
ATOM   3374 N  N   . THR A 1 440 ? -7.99539  -3.33132  10.99803  1.000 43.54828  ?  440  THR A N   1 
ATOM   3375 C  CA  . THR A 1 440 ? -6.69263  -3.40199  10.35606  1.000 40.61764  ?  440  THR A CA  1 
ATOM   3376 C  C   . THR A 1 440 ? -5.69378  -2.77751  11.32297  1.000 48.10488  ?  440  THR A C   1 
ATOM   3377 O  O   . THR A 1 440 ? -5.71559  -1.55788  11.53817  1.000 39.11520  ?  440  THR A O   1 
ATOM   3378 C  CB  . THR A 1 440 ? -6.70342  -2.67324  9.01950   1.000 46.24026  ?  440  THR A CB  1 
ATOM   3379 O  OG1 . THR A 1 440 ? -7.64836  -3.30497  8.15911   1.000 47.43825  ?  440  THR A OG1 1 
ATOM   3380 C  CG2 . THR A 1 440 ? -5.33176  -2.74601  8.37408   1.000 46.21074  ?  440  THR A CG2 1 
ATOM   3381 N  N   . ILE A 1 441 ? -4.82950  -3.61346  11.91224  1.000 41.16589  ?  441  ILE A N   1 
ATOM   3382 C  CA  . ILE A 1 441 ? -3.86690  -3.11952  12.90019  1.000 38.95798  ?  441  ILE A CA  1 
ATOM   3383 C  C   . ILE A 1 441 ? -2.86353  -2.16322  12.25160  1.000 42.18757  ?  441  ILE A C   1 
ATOM   3384 O  O   . ILE A 1 441 ? -2.64471  -1.03974  12.72791  1.000 42.03240  ?  441  ILE A O   1 
ATOM   3385 C  CB  . ILE A 1 441 ? -3.15193  -4.30411  13.57774  1.000 44.66808  ?  441  ILE A CB  1 
ATOM   3386 C  CG1 . ILE A 1 441 ? -4.10630  -5.04798  14.51187  1.000 40.47603  ?  441  ILE A CG1 1 
ATOM   3387 C  CG2 . ILE A 1 441 ? -1.91258  -3.82916  14.34220  1.000 42.50750  ?  441  ILE A CG2 1 
ATOM   3388 C  CD1 . ILE A 1 441 ? -3.53288  -6.35422  15.04317  1.000 33.89162  ?  441  ILE A CD1 1 
ATOM   3389 N  N   . LEU A 1 442 ? -2.23689  -2.59267  11.15919  1.000 40.17592  ?  442  LEU A N   1 
ATOM   3390 C  CA  . LEU A 1 442 ? -1.29787  -1.76116  10.41369  1.000 43.14455  ?  442  LEU A CA  1 
ATOM   3391 C  C   . LEU A 1 442 ? -1.78781  -1.64983  8.98464   1.000 41.83521  ?  442  LEU A C   1 
ATOM   3392 O  O   . LEU A 1 442 ? -1.97464  -2.66648  8.30781   1.000 41.39431  ?  442  LEU A O   1 
ATOM   3393 C  CB  . LEU A 1 442 ? 0.12187   -2.32622  10.44115  1.000 33.69103  ?  442  LEU A CB  1 
ATOM   3394 C  CG  . LEU A 1 442 ? 0.80318   -2.11462  11.78346  1.000 33.88141  ?  442  LEU A CG  1 
ATOM   3395 C  CD1 . LEU A 1 442 ? 2.13233   -2.84408  11.77756  1.000 37.17495  ?  442  LEU A CD1 1 
ATOM   3396 C  CD2 . LEU A 1 442 ? 0.97255   -0.61794  12.02574  1.000 39.79138  ?  442  LEU A CD2 1 
ATOM   3397 N  N   . GLU A 1 443 ? -1.95757  -0.41545  8.52551   1.000 40.82636  ?  443  GLU A N   1 
ATOM   3398 C  CA  . GLU A 1 443 ? -2.61150  -0.15715  7.25286   1.000 43.78017  ?  443  GLU A CA  1 
ATOM   3399 C  C   . GLU A 1 443 ? -1.84401  -0.68435  6.04995   1.000 44.01674  ?  443  GLU A C   1 
ATOM   3400 O  O   . GLU A 1 443 ? -2.44345  -0.83530  4.98115   1.000 53.58097  ?  443  GLU A O   1 
ATOM   3401 C  CB  . GLU A 1 443 ? -2.83621  1.34305   7.10415   1.000 47.51960  ?  443  GLU A CB  1 
ATOM   3402 C  CG  . GLU A 1 443 ? -3.98056  1.70699   6.18782   1.000 53.74442  ?  443  GLU A CG  1 
ATOM   3403 C  CD  . GLU A 1 443 ? -3.97326  3.18487   5.84356   1.000 58.97855  ?  443  GLU A CD  1 
ATOM   3404 O  OE1 . GLU A 1 443 ? -2.99241  3.86868   6.23192   1.000 60.83988  ?  443  GLU A OE1 1 
ATOM   3405 O  OE2 . GLU A 1 443 ? -4.93125  3.65553   5.17785   1.000 59.79523  -1 443  GLU A OE2 1 
ATOM   3406 N  N   . GLY A 1 444 ? -0.55860  -0.99193  6.17983   1.000 41.77159  ?  444  GLY A N   1 
ATOM   3407 C  CA  . GLY A 1 444 ? 0.20120   -1.31520  4.99061   1.000 44.81564  ?  444  GLY A CA  1 
ATOM   3408 C  C   . GLY A 1 444 ? 0.55167   -2.76656  4.73261   1.000 43.18505  ?  444  GLY A C   1 
ATOM   3409 O  O   . GLY A 1 444 ? 1.26783   -3.05222  3.76953   1.000 53.40390  ?  444  GLY A O   1 
ATOM   3410 N  N   . LEU A 1 445 ? 0.09330   -3.67755  5.53175   1.000 44.64540  ?  445  LEU A N   1 
ATOM   3411 C  CA  . LEU A 1 445 ? 0.64723   -5.01470  5.39464   1.000 49.15885  ?  445  LEU A CA  1 
ATOM   3412 C  C   . LEU A 1 445 ? -0.21205  -5.88150  4.47691   1.000 56.68696  ?  445  LEU A C   1 
ATOM   3413 O  O   . LEU A 1 445 ? -1.37016  -5.55000  4.18571   1.000 54.37447  ?  445  LEU A O   1 
ATOM   3414 C  CB  . LEU A 1 445 ? 0.76685   -5.66015  6.77449   1.000 40.93154  ?  445  LEU A CB  1 
ATOM   3415 C  CG  . LEU A 1 445 ? 1.75866   -4.98918  7.70050   1.000 39.82647  ?  445  LEU A CG  1 
ATOM   3416 C  CD1 . LEU A 1 445 ? 1.67725   -5.60483  9.08392   1.000 41.59032  ?  445  LEU A CD1 1 
ATOM   3417 C  CD2 . LEU A 1 445 ? 3.16560   -5.13949  7.13759   1.000 36.52520  ?  445  LEU A CD2 1 
ATOM   3418 N  N   . PRO A 1 446 ? 0.34211   -7.01560  3.98308   1.000 55.75094  ?  446  PRO A N   1 
ATOM   3419 C  CA  . PRO A 1 446 ? -0.50556  -8.04672  3.36676   1.000 58.45260  ?  446  PRO A CA  1 
ATOM   3420 C  C   . PRO A 1 446 ? -1.45842  -8.62629  4.40163   1.000 60.40691  ?  446  PRO A C   1 
ATOM   3421 O  O   . PRO A 1 446 ? -1.46937  -8.16864  5.54933   1.000 63.19206  ?  446  PRO A O   1 
ATOM   3422 C  CB  . PRO A 1 446 ? 0.49922   -9.10234  2.87198   1.000 60.73166  ?  446  PRO A CB  1 
ATOM   3423 C  CG  . PRO A 1 446 ? 1.79558   -8.41053  2.77493   1.000 53.98372  ?  446  PRO A CG  1 
ATOM   3424 C  CD  . PRO A 1 446 ? 1.77592   -7.31492  3.82390   1.000 56.99392  ?  446  PRO A CD  1 
ATOM   3425 N  N   . ASP A 1 447 ? -2.28113  -9.60066  4.02534   1.000 57.76042  ?  447  ASP A N   1 
ATOM   3426 C  CA  . ASP A 1 447 ? -3.30895  -10.05742 4.94631   1.000 52.36528  ?  447  ASP A CA  1 
ATOM   3427 C  C   . ASP A 1 447 ? -2.68152  -10.79334 6.12239   1.000 50.66675  ?  447  ASP A C   1 
ATOM   3428 O  O   . ASP A 1 447 ? -1.74148  -11.57952 5.96844   1.000 50.69597  ?  447  ASP A O   1 
ATOM   3429 C  CB  . ASP A 1 447 ? -4.33118  -10.94477 4.23695   1.000 62.95221  ?  447  ASP A CB  1 
ATOM   3430 C  CG  . ASP A 1 447 ? -3.68923  -12.06912 3.46702   1.000 69.67660  ?  447  ASP A CG  1 
ATOM   3431 O  OD1 . ASP A 1 447 ? -2.44324  -12.02850 3.30147   1.000 71.09116  -1 447  ASP A OD1 1 
ATOM   3432 O  OD2 . ASP A 1 447 ? -4.42699  -12.99555 3.03944   1.000 72.62728  -1 447  ASP A OD2 1 
ATOM   3433 N  N   . VAL A 1 448 ? -3.22244  -10.52491 7.30216   1.000 46.94204  ?  448  VAL A N   1 
ATOM   3434 C  CA  . VAL A 1 448 ? -2.67415  -10.96346 8.57558   1.000 43.61700  ?  448  VAL A CA  1 
ATOM   3435 C  C   . VAL A 1 448 ? -3.66381  -11.95295 9.17520   1.000 41.14304  ?  448  VAL A C   1 
ATOM   3436 O  O   . VAL A 1 448 ? -4.85877  -11.65833 9.27310   1.000 39.52228  ?  448  VAL A O   1 
ATOM   3437 C  CB  . VAL A 1 448 ? -2.44343  -9.75053  9.49901   1.000 43.23788  ?  448  VAL A CB  1 
ATOM   3438 C  CG1 . VAL A 1 448 ? -2.17462  -10.17747 10.93457  1.000 33.57687  ?  448  VAL A CG1 1 
ATOM   3439 C  CG2 . VAL A 1 448 ? -1.31897  -8.85659  8.94388   1.000 40.60603  ?  448  VAL A CG2 1 
ATOM   3440 N  N   . ARG A 1 449 ? -3.18618  -13.13627 9.53596   1.000 40.05216  ?  449  ARG A N   1 
ATOM   3441 C  CA  . ARG A 1 449 ? -4.06140  -14.13885 10.12255  1.000 39.40733  ?  449  ARG A CA  1 
ATOM   3442 C  C   . ARG A 1 449 ? -4.26538  -13.83075 11.61153  1.000 35.79658  ?  449  ARG A C   1 
ATOM   3443 O  O   . ARG A 1 449 ? -3.29508  -13.71501 12.35803  1.000 34.30165  ?  449  ARG A O   1 
ATOM   3444 C  CB  . ARG A 1 449 ? -3.46575  -15.53591 9.91903   1.000 44.34732  ?  449  ARG A CB  1 
ATOM   3445 C  CG  . ARG A 1 449 ? -4.39414  -16.65130 10.38112  1.000 42.50719  ?  449  ARG A CG  1 
ATOM   3446 C  CD  . ARG A 1 449 ? -5.32352  -17.11604 9.26545   1.000 48.98119  ?  449  ARG A CD  1 
ATOM   3447 N  NE  . ARG A 1 449 ? -4.84915  -18.37244 8.69408   1.000 59.84784  ?  449  ARG A NE  1 
ATOM   3448 C  CZ  . ARG A 1 449 ? -5.00396  -18.74912 7.43101   1.000 64.14065  ?  449  ARG A CZ  1 
ATOM   3449 N  NH1 . ARG A 1 449 ? -5.63177  -17.98462 6.54934   1.000 63.36829  ?  449  ARG A NH1 1 
ATOM   3450 N  NH2 . ARG A 1 449 ? -4.50722  -19.92163 7.04071   1.000 68.07051  ?  449  ARG A NH2 1 
ATOM   3451 N  N   . GLU A 1 450 ? -5.51517  -13.67625 12.05297  1.000 39.10479  ?  450  GLU A N   1 
ATOM   3452 C  CA  . GLU A 1 450 ? -5.76164  -13.49050 13.47900  1.000 33.05741  ?  450  GLU A CA  1 
ATOM   3453 C  C   . GLU A 1 450 ? -5.78985  -14.84155 14.18082  1.000 43.11571  ?  450  GLU A C   1 
ATOM   3454 O  O   . GLU A 1 450 ? -6.49054  -15.76625 13.74908  1.000 43.87824  ?  450  GLU A O   1 
ATOM   3455 C  CB  . GLU A 1 450 ? -7.05633  -12.74129 13.73909  1.000 39.95538  ?  450  GLU A CB  1 
ATOM   3456 C  CG  . GLU A 1 450 ? -7.51596  -12.78163 15.23677  1.000 40.30846  ?  450  GLU A CG  1 
ATOM   3457 C  CD  . GLU A 1 450 ? -6.55698  -12.08053 16.22240  1.000 40.68960  ?  450  GLU A CD  1 
ATOM   3458 O  OE1 . GLU A 1 450 ? -6.16740  -10.88898 15.99296  1.000 33.57278  ?  450  GLU A OE1 1 
ATOM   3459 O  OE2 . GLU A 1 450 ? -6.23310  -12.70799 17.25992  1.000 34.80744  -1 450  GLU A OE2 1 
ATOM   3460 N  N   . ILE A 1 451 ? -5.01001  -14.94524 15.26305  1.000 40.53109  ?  451  ILE A N   1 
ATOM   3461 C  CA  . ILE A 1 451 ? -4.84813  -16.19513 15.99155  1.000 40.19479  ?  451  ILE A CA  1 
ATOM   3462 C  C   . ILE A 1 451 ? -6.08839  -16.51481 16.82310  1.000 46.61276  ?  451  ILE A C   1 
ATOM   3463 O  O   . ILE A 1 451 ? -6.52129  -17.67054 16.89951  1.000 47.11453  ?  451  ILE A O   1 
ATOM   3464 C  CB  . ILE A 1 451 ? -3.57703  -16.11223 16.85125  1.000 44.16008  ?  451  ILE A CB  1 
ATOM   3465 C  CG1 . ILE A 1 451 ? -2.34160  -16.14800 15.94226  1.000 36.38356  ?  451  ILE A CG1 1 
ATOM   3466 C  CG2 . ILE A 1 451 ? -3.55252  -17.19971 17.95535  1.000 39.67920  ?  451  ILE A CG2 1 
ATOM   3467 C  CD1 . ILE A 1 451 ? -1.08572  -15.69370 16.62034  1.000 34.84989  ?  451  ILE A CD1 1 
ATOM   3468 N  N   . VAL A 1 452 ? -6.66460  -15.51656 17.47382  1.000 42.12675  ?  452  VAL A N   1 
ATOM   3469 C  CA  . VAL A 1 452 ? -7.82662  -15.71643 18.33954  1.000 48.75781  ?  452  VAL A CA  1 
ATOM   3470 C  C   . VAL A 1 452 ? -9.05478  -15.26648 17.55604  1.000 51.88698  ?  452  VAL A C   1 
ATOM   3471 O  O   . VAL A 1 452 ? -9.50353  -14.11762 17.65864  1.000 55.65118  ?  452  VAL A O   1 
ATOM   3472 C  CB  . VAL A 1 452 ? -7.68977  -14.96358 19.66388  1.000 45.23037  ?  452  VAL A CB  1 
ATOM   3473 C  CG1 . VAL A 1 452 ? -8.84875  -15.32516 20.59135  1.000 51.73063  ?  452  VAL A CG1 1 
ATOM   3474 C  CG2 . VAL A 1 452 ? -6.37897  -15.30631 20.33644  1.000 38.46990  ?  452  VAL A CG2 1 
ATOM   3475 N  N   . ALA A 1 453 ? -9.63500  -16.18718 16.78752  1.000 54.97000  ?  453  ALA A N   1 
ATOM   3476 C  CA  . ALA A 1 453 ? -10.90199 -15.92349 16.11505  1.000 60.24241  ?  453  ALA A CA  1 
ATOM   3477 C  C   . ALA A 1 453 ? -12.07908 -16.66628 16.72998  1.000 67.95465  ?  453  ALA A C   1 
ATOM   3478 O  O   . ALA A 1 453 ? -13.22464 -16.25512 16.51663  1.000 71.52152  ?  453  ALA A O   1 
ATOM   3479 C  CB  . ALA A 1 453 ? -10.81070 -16.27788 14.62427  1.000 61.20410  ?  453  ALA A CB  1 
ATOM   3480 N  N   . ASP A 1 454 ? -11.82557 -17.74279 17.47523  1.000 67.45285  ?  454  ASP A N   1 
ATOM   3481 C  CA  . ASP A 1 454 ? -12.85393 -18.35467 18.30626  1.000 70.25072  ?  454  ASP A CA  1 
ATOM   3482 C  C   . ASP A 1 454 ? -13.30727 -17.38072 19.39121  1.000 77.25404  ?  454  ASP A C   1 
ATOM   3483 O  O   . ASP A 1 454 ? -12.48492 -16.75734 20.06873  1.000 73.96660  ?  454  ASP A O   1 
ATOM   3484 C  CB  . ASP A 1 454 ? -12.30612 -19.63432 18.93841  1.000 72.78777  ?  454  ASP A CB  1 
ATOM   3485 C  CG  . ASP A 1 454 ? -13.37966 -20.64707 19.23200  1.000 85.37206  ?  454  ASP A CG  1 
ATOM   3486 O  OD1 . ASP A 1 454 ? -14.54227 -20.22960 19.43747  1.000 89.22309  -1 454  ASP A OD1 1 
ATOM   3487 O  OD2 . ASP A 1 454 ? -13.05325 -21.85554 19.28135  1.000 83.45535  -1 454  ASP A OD2 1 
ATOM   3488 N  N   . LYS A 1 455 ? -14.62310 -17.27435 19.57779  1.000 84.11350  ?  455  LYS A N   1 
ATOM   3489 C  CA  . LYS A 1 455 ? -15.22755 -16.25234 20.42490  1.000 83.36078  ?  455  LYS A CA  1 
ATOM   3490 C  C   . LYS A 1 455 ? -15.76388 -16.82970 21.73445  1.000 75.84344  ?  455  LYS A C   1 
ATOM   3491 O  O   . LYS A 1 455 ? -15.98471 -18.03622 21.86865  1.000 76.60612  ?  455  LYS A O   1 
ATOM   3492 C  CB  . LYS A 1 455 ? -16.36588 -15.53949 19.68063  1.000 82.35515  ?  455  LYS A CB  1 
ATOM   3493 C  CG  . LYS A 1 455 ? -16.08897 -15.24924 18.20676  1.000 79.55887  ?  455  LYS A CG  1 
ATOM   3494 C  CD  . LYS A 1 455 ? -17.28183 -14.54244 17.55735  1.000 77.01934  ?  455  LYS A CD  1 
ATOM   3495 C  CE  . LYS A 1 455 ? -16.89590 -13.89072 16.23418  1.000 73.01338  ?  455  LYS A CE  1 
ATOM   3496 N  NZ  . LYS A 1 455 ? -15.95353 -12.74914 16.43231  1.000 66.12424  ?  455  LYS A NZ  1 
ATOM   3497 N  N   . ILE A 1 456 ? -15.97567 -15.93009 22.69922  1.000 80.59319  ?  456  ILE A N   1 
ATOM   3498 C  CA  . ILE A 1 456 ? -16.62380 -16.22166 23.99424  1.000 80.67885  ?  456  ILE A CA  1 
ATOM   3499 C  C   . ILE A 1 456 ? -16.03912 -17.43391 24.71833  1.000 75.25224  ?  456  ILE A C   1 
ATOM   3500 O  O   . ILE A 1 456 ? -15.25389 -17.29148 25.66438  1.000 76.73570  ?  456  ILE A O   1 
ATOM   3501 C  CB  . ILE A 1 456 ? -18.13401 -16.40763 23.80336  1.000 71.18456  ?  456  ILE A CB  1 
ATOM   3502 N  N   . LYS A 1 461 ? -16.09879 -12.66054 29.39454  1.000 57.80232  ?  461  LYS A N   1 
ATOM   3503 C  CA  . LYS A 1 461 ? -17.53043 -12.39904 29.43345  1.000 62.12853  ?  461  LYS A CA  1 
ATOM   3504 C  C   . LYS A 1 461 ? -17.90018 -11.15572 30.27596  1.000 55.58828  ?  461  LYS A C   1 
ATOM   3505 O  O   . LYS A 1 461 ? -18.69300 -10.32681 29.82826  1.000 57.82335  ?  461  LYS A O   1 
ATOM   3506 C  CB  . LYS A 1 461 ? -18.28476 -13.64313 29.95263  1.000 51.35607  ?  461  LYS A CB  1 
ATOM   3507 N  N   . LEU A 1 462 ? -17.34413 -11.01096 31.47924  1.000 53.35467  ?  462  LEU A N   1 
ATOM   3508 C  CA  . LEU A 1 462 ? -17.87726 -10.05321 32.44788  1.000 58.16335  ?  462  LEU A CA  1 
ATOM   3509 C  C   . LEU A 1 462 ? -17.04471 -8.77218  32.52998  1.000 52.67467  ?  462  LEU A C   1 
ATOM   3510 O  O   . LEU A 1 462 ? -15.80866 -8.80775  32.55652  1.000 49.72937  ?  462  LEU A O   1 
ATOM   3511 C  CB  . LEU A 1 462 ? -17.99669 -10.69139 33.83497  1.000 59.42447  ?  462  LEU A CB  1 
ATOM   3512 C  CG  . LEU A 1 462 ? -16.72895 -11.18016 34.53631  1.000 69.28069  ?  462  LEU A CG  1 
ATOM   3513 C  CD1 . LEU A 1 462 ? -16.17382 -10.11408 35.52137  1.000 65.53828  ?  462  LEU A CD1 1 
ATOM   3514 C  CD2 . LEU A 1 462 ? -16.98724 -12.51892 35.23125  1.000 67.77017  ?  462  LEU A CD2 1 
ATOM   3515 N  N   . ARG A 1 463 ? -17.74695 -7.64334  32.59448  1.000 49.80106  ?  463  ARG A N   1 
ATOM   3516 C  CA  . ARG A 1 463 ? -17.11908 -6.32799  32.60660  1.000 47.95856  ?  463  ARG A CA  1 
ATOM   3517 C  C   . ARG A 1 463 ? -16.20946 -6.16524  33.82244  1.000 44.45531  ?  463  ARG A C   1 
ATOM   3518 O  O   . ARG A 1 463 ? -16.45211 -6.72826  34.89315  1.000 48.10741  ?  463  ARG A O   1 
ATOM   3519 C  CB  . ARG A 1 463 ? -18.20601 -5.24920  32.61270  1.000 46.19157  ?  463  ARG A CB  1 
ATOM   3520 C  CG  . ARG A 1 463 ? -17.84116 -3.99462  31.86283  1.000 50.52874  ?  463  ARG A CG  1 
ATOM   3521 C  CD  . ARG A 1 463 ? -19.05922 -3.30699  31.28567  1.000 62.28780  ?  463  ARG A CD  1 
ATOM   3522 N  NE  . ARG A 1 463 ? -18.68405 -2.56377  30.08654  1.000 69.20174  ?  463  ARG A NE  1 
ATOM   3523 C  CZ  . ARG A 1 463 ? -19.04566 -2.88590  28.85145  1.000 66.26783  ?  463  ARG A CZ  1 
ATOM   3524 N  NH1 . ARG A 1 463 ? -19.87303 -3.89145  28.61199  1.000 68.64026  ?  463  ARG A NH1 1 
ATOM   3525 N  NH2 . ARG A 1 463 ? -18.56316 -2.18196  27.83033  1.000 61.67938  ?  463  ARG A NH2 1 
ATOM   3526 N  N   . ARG A 1 464 ? -15.15073 -5.38099  33.66193  1.000 36.84903  ?  464  ARG A N   1 
ATOM   3527 C  CA  . ARG A 1 464 ? -14.25541 -5.15125  34.78284  1.000 36.41062  ?  464  ARG A CA  1 
ATOM   3528 C  C   . ARG A 1 464 ? -14.25972 -3.71742  35.29596  1.000 37.02491  ?  464  ARG A C   1 
ATOM   3529 O  O   . ARG A 1 464 ? -14.01168 -3.50925  36.48368  1.000 34.05664  ?  464  ARG A O   1 
ATOM   3530 C  CB  . ARG A 1 464 ? -12.82457 -5.55102  34.41285  1.000 37.42914  ?  464  ARG A CB  1 
ATOM   3531 C  CG  . ARG A 1 464 ? -12.52486 -7.04299  34.55651  1.000 37.36091  ?  464  ARG A CG  1 
ATOM   3532 C  CD  . ARG A 1 464 ? -11.17367 -7.42481  33.96252  1.000 33.53941  ?  464  ARG A CD  1 
ATOM   3533 N  NE  . ARG A 1 464 ? -11.09533 -7.13440  32.53063  1.000 36.37219  ?  464  ARG A NE  1 
ATOM   3534 C  CZ  . ARG A 1 464 ? -9.98068  -7.18704  31.81057  1.000 41.10130  ?  464  ARG A CZ  1 
ATOM   3535 N  NH1 . ARG A 1 464 ? -8.81612  -7.47577  32.36222  1.000 43.74289  ?  464  ARG A NH1 1 
ATOM   3536 N  NH2 . ARG A 1 464 ? -10.03479 -6.94109  30.50305  1.000 41.16014  ?  464  ARG A NH2 1 
ATOM   3537 N  N   . VAL A 1 465 ? -14.54022 -2.72346  34.45357  1.000 34.61154  ?  465  VAL A N   1 
ATOM   3538 C  CA  . VAL A 1 465 ? -14.46295 -1.32097  34.86309  1.000 37.86707  ?  465  VAL A CA  1 
ATOM   3539 C  C   . VAL A 1 465 ? -15.68916 -0.55679  34.35569  1.000 34.45385  ?  465  VAL A C   1 
ATOM   3540 O  O   . VAL A 1 465 ? -16.44057 -1.02626  33.50394  1.000 33.14694  ?  465  VAL A O   1 
ATOM   3541 C  CB  . VAL A 1 465 ? -13.17437 -0.63276  34.35185  1.000 31.63211  ?  465  VAL A CB  1 
ATOM   3542 C  CG1 . VAL A 1 465 ? -11.95888 -1.24250  34.95962  1.000 36.45540  ?  465  VAL A CG1 1 
ATOM   3543 C  CG2 . VAL A 1 465 ? -13.09521 -0.73687  32.84382  1.000 33.23659  ?  465  VAL A CG2 1 
ATOM   3544 N  N   . ARG A 1 466 ? -15.87098 0.64333   34.89869  1.000 34.40561  ?  466  ARG A N   1 
ATOM   3545 C  CA  . ARG A 1 466 ? -16.67928 1.69054   34.29467  1.000 33.12480  ?  466  ARG A CA  1 
ATOM   3546 C  C   . ARG A 1 466 ? -15.75138 2.83900   33.90598  1.000 36.76375  ?  466  ARG A C   1 
ATOM   3547 O  O   . ARG A 1 466 ? -14.78783 3.13780   34.62125  1.000 32.07817  ?  466  ARG A O   1 
ATOM   3548 C  CB  . ARG A 1 466 ? -17.76004 2.18906   35.25423  1.000 36.10384  ?  466  ARG A CB  1 
ATOM   3549 C  CG  . ARG A 1 466 ? -17.25296 2.37295   36.69550  1.000 45.62951  ?  466  ARG A CG  1 
ATOM   3550 C  CD  . ARG A 1 466 ? -18.36140 2.80424   37.68286  1.000 53.12282  ?  466  ARG A CD  1 
ATOM   3551 N  NE  . ARG A 1 466 ? -17.83910 2.94972   39.03852  1.000 52.90731  ?  466  ARG A NE  1 
ATOM   3552 C  CZ  . ARG A 1 466 ? -17.70925 4.09276   39.70717  1.000 54.78373  ?  466  ARG A CZ  1 
ATOM   3553 N  NH1 . ARG A 1 466 ? -18.05919 5.26511   39.17082  1.000 48.40217  ?  466  ARG A NH1 1 
ATOM   3554 N  NH2 . ARG A 1 466 ? -17.22348 4.05825   40.95227  1.000 41.65475  ?  466  ARG A NH2 1 
ATOM   3555 N  N   . ILE A 1 467 ? -16.02967 3.47619   32.77166  1.000 36.29863  ?  467  ILE A N   1 
ATOM   3556 C  CA  . ILE A 1 467 ? -15.14901 4.49595   32.21374  1.000 39.62590  ?  467  ILE A CA  1 
ATOM   3557 C  C   . ILE A 1 467 ? -15.91199 5.80613   32.08767  1.000 41.54840  ?  467  ILE A C   1 
ATOM   3558 O  O   . ILE A 1 467 ? -17.01991 5.83574   31.54114  1.000 37.45274  ?  467  ILE A O   1 
ATOM   3559 C  CB  . ILE A 1 467 ? -14.57550 4.08286   30.84706  1.000 35.25364  ?  467  ILE A CB  1 
ATOM   3560 C  CG1 . ILE A 1 467 ? -13.75559 2.79607   30.96851  1.000 39.64948  ?  467  ILE A CG1 1 
ATOM   3561 C  CG2 . ILE A 1 467 ? -13.71340 5.21979   30.27602  1.000 37.15215  ?  467  ILE A CG2 1 
ATOM   3562 C  CD1 . ILE A 1 467 ? -12.80412 2.55989   29.81599  1.000 34.03907  ?  467  ILE A CD1 1 
ATOM   3563 N  N   . LYS A 1 468 ? -15.30197 6.88872   32.56828  1.000 38.79721  ?  468  LYS A N   1 
ATOM   3564 C  CA  . LYS A 1 468 ? -15.84739 8.23106   32.44961  1.000 35.72447  ?  468  LYS A CA  1 
ATOM   3565 C  C   . LYS A 1 468 ? -14.93612 9.06366   31.54717  1.000 36.79145  ?  468  LYS A C   1 
ATOM   3566 O  O   . LYS A 1 468 ? -13.70975 9.01377   31.68647  1.000 38.73666  ?  468  LYS A O   1 
ATOM   3567 C  CB  . LYS A 1 468 ? -16.00032 8.85273   33.84039  1.000 40.33419  ?  468  LYS A CB  1 
ATOM   3568 C  CG  . LYS A 1 468 ? -16.23787 10.37177  33.85884  1.000 46.60406  ?  468  LYS A CG  1 
ATOM   3569 C  CD  . LYS A 1 468 ? -17.66474 10.71707  33.42285  1.000 51.05557  ?  468  LYS A CD  1 
ATOM   3570 C  CE  . LYS A 1 468 ? -18.60264 10.89066  34.61329  1.000 63.55127  ?  468  LYS A CE  1 
ATOM   3571 N  NZ  . LYS A 1 468 ? -20.05433 10.86828  34.20388  1.000 66.44917  ?  468  LYS A NZ  1 
ATOM   3572 N  N   . MET A 1 469 ? -15.53155 9.80603   30.60767  1.000 35.41363  ?  469  MET A N   1 
ATOM   3573 C  CA  . MET A 1 469 ? -14.82688 10.62001  29.61081  1.000 40.05079  ?  469  MET A CA  1 
ATOM   3574 C  C   . MET A 1 469 ? -14.91693 12.10956  29.94818  1.000 32.28328  ?  469  MET A C   1 
ATOM   3575 O  O   . MET A 1 469 ? -15.81606 12.53108  30.67803  1.000 35.43166  ?  469  MET A O   1 
ATOM   3576 C  CB  . MET A 1 469 ? -15.40779 10.36963  28.20509  1.000 32.00539  ?  469  MET A CB  1 
ATOM   3577 C  CG  . MET A 1 469 ? -15.16278 8.98112   27.61339  1.000 37.56808  ?  469  MET A CG  1 
ATOM   3578 S  SD  . MET A 1 469 ? -13.46049 8.35617   27.55185  1.000 37.73755  ?  469  MET A SD  1 
ATOM   3579 C  CE  . MET A 1 469 ? -12.69237 9.52153   26.39662  1.000 32.69489  ?  469  MET A CE  1 
ATOM   3580 N  N   . PRO A 1 470 ? -14.00735 12.93372  29.43616  1.000 32.00853  ?  470  PRO A N   1 
ATOM   3581 C  CA  . PRO A 1 470 ? -14.09038 14.39850  29.68480  1.000 35.57156  ?  470  PRO A CA  1 
ATOM   3582 C  C   . PRO A 1 470 ? -15.23271 15.01712  28.89478  1.000 41.37934  ?  470  PRO A C   1 
ATOM   3583 O  O   . PRO A 1 470 ? -15.87259 14.33844  28.07181  1.000 42.41441  ?  470  PRO A O   1 
ATOM   3584 C  CB  . PRO A 1 470 ? -12.72287 14.92417  29.20959  1.000 37.19388  ?  470  PRO A CB  1 
ATOM   3585 C  CG  . PRO A 1 470 ? -12.15358 13.84397  28.33721  1.000 36.17864  ?  470  PRO A CG  1 
ATOM   3586 C  CD  . PRO A 1 470 ? -12.75685 12.54634  28.77058  1.000 33.03159  ?  470  PRO A CD  1 
ATOM   3587 N  N   . PRO A 1 471 ? -15.55812 16.28425  29.14454  1.000 40.24403  ?  471  PRO A N   1 
ATOM   3588 C  CA  . PRO A 1 471 ? -16.70575 16.90160  28.46836  1.000 41.02249  ?  471  PRO A CA  1 
ATOM   3589 C  C   . PRO A 1 471 ? -16.41037 17.22246  27.01319  1.000 41.13168  ?  471  PRO A C   1 
ATOM   3590 O  O   . PRO A 1 471 ? -15.33377 17.72663  26.66163  1.000 37.22441  ?  471  PRO A O   1 
ATOM   3591 C  CB  . PRO A 1 471 ? -16.95371 18.18322  29.27943  1.000 42.33241  ?  471  PRO A CB  1 
ATOM   3592 C  CG  . PRO A 1 471 ? -15.68099 18.45928  29.97495  1.000 43.73768  ?  471  PRO A CG  1 
ATOM   3593 C  CD  . PRO A 1 471 ? -15.04541 17.12891  30.23976  1.000 41.28922  ?  471  PRO A CD  1 
ATOM   3594 N  N   . PRO A 1 472 ? -17.38140 16.99382  26.14193  1.000 43.64737  ?  472  PRO A N   1 
ATOM   3595 C  CA  . PRO A 1 472 ? -17.24454 17.41247  24.73800  1.000 41.68979  ?  472  PRO A CA  1 
ATOM   3596 C  C   . PRO A 1 472 ? -16.91766 18.89182  24.54480  1.000 44.30034  ?  472  PRO A C   1 
ATOM   3597 O  O   . PRO A 1 472 ? -16.26432 19.24912  23.55154  1.000 42.61585  ?  472  PRO A O   1 
ATOM   3598 C  CB  . PRO A 1 472 ? -18.61991 17.07039  24.15209  1.000 38.80671  ?  472  PRO A CB  1 
ATOM   3599 C  CG  . PRO A 1 472 ? -19.12874 15.99560  25.01050  1.000 39.98814  ?  472  PRO A CG  1 
ATOM   3600 C  CD  . PRO A 1 472 ? -18.62809 16.26326  26.39359  1.000 36.96374  ?  472  PRO A CD  1 
ATOM   3601 N  N   . ASN A 1 473 ? -17.33042 19.76940  25.45872  1.000 40.67542  ?  473  ASN A N   1 
ATOM   3602 C  CA  . ASN A 1 473 ? -17.08282 21.18767  25.22383  1.000 41.54272  ?  473  ASN A CA  1 
ATOM   3603 C  C   . ASN A 1 473 ? -15.59986 21.52774  25.09658  1.000 44.04575  ?  473  ASN A C   1 
ATOM   3604 O  O   . ASN A 1 473 ? -15.27246 22.67152  24.73774  1.000 40.77926  ?  473  ASN A O   1 
ATOM   3605 C  CB  . ASN A 1 473 ? -17.72716 22.01635  26.32656  1.000 41.83550  ?  473  ASN A CB  1 
ATOM   3606 C  CG  . ASN A 1 473 ? -17.24856 21.63000  27.68744  1.000 47.09909  ?  473  ASN A CG  1 
ATOM   3607 O  OD1 . ASN A 1 473 ? -16.05655 21.41992  27.89530  1.000 48.15604  ?  473  ASN A OD1 1 
ATOM   3608 N  ND2 . ASN A 1 473 ? -18.17012 21.54634  28.63885  1.000 50.73229  ?  473  ASN A ND2 1 
ATOM   3609 N  N   . GLY A 1 474 ? -14.70120 20.57350  25.37087  1.000 39.74089  ?  474  GLY A N   1 
ATOM   3610 C  CA  . GLY A 1 474 ? -13.27947 20.77765  25.18968  1.000 39.15459  ?  474  GLY A CA  1 
ATOM   3611 C  C   . GLY A 1 474 ? -12.55449 21.46855  26.33488  1.000 39.21974  ?  474  GLY A C   1 
ATOM   3612 O  O   . GLY A 1 474 ? -11.34615 21.71547  26.21983  1.000 38.19589  ?  474  GLY A O   1 
ATOM   3613 N  N   . GLU A 1 475 ? -13.23200 21.77247  27.43532  1.000 38.84857  ?  475  GLU A N   1 
ATOM   3614 C  CA  . GLU A 1 475 ? -12.56860 22.46360  28.52776  1.000 45.59508  ?  475  GLU A CA  1 
ATOM   3615 C  C   . GLU A 1 475 ? -11.52453 21.57970  29.19471  1.000 41.24215  ?  475  GLU A C   1 
ATOM   3616 O  O   . GLU A 1 475 ? -11.66909 20.36009  29.28709  1.000 38.62193  ?  475  GLU A O   1 
ATOM   3617 C  CB  . GLU A 1 475 ? -13.58334 22.94394  29.55626  1.000 46.07059  ?  475  GLU A CB  1 
ATOM   3618 C  CG  . GLU A 1 475 ? -13.87933 24.40983  29.34502  1.000 50.92989  ?  475  GLU A CG  1 
ATOM   3619 C  CD  . GLU A 1 475 ? -15.32421 24.74964  29.51583  1.000 60.06234  ?  475  GLU A CD  1 
ATOM   3620 O  OE1 . GLU A 1 475 ? -15.96517 24.08313  30.37436  1.000 61.03350  ?  475  GLU A OE1 1 
ATOM   3621 O  OE2 . GLU A 1 475 ? -15.80021 25.67168  28.78089  1.000 52.34518  -1 475  GLU A OE2 1 
ATOM   3622 N  N   . THR A 1 476 ? -10.45858 22.21726  29.65444  1.000 41.31529  ?  476  THR A N   1 
ATOM   3623 C  CA  . THR A 1 476 ? -9.36251  21.53826  30.31634  1.000 37.99719  ?  476  THR A CA  1 
ATOM   3624 C  C   . THR A 1 476 ? -9.39167  21.82383  31.80799  1.000 37.02071  ?  476  THR A C   1 
ATOM   3625 O  O   . THR A 1 476 ? -9.88043  22.86303  32.25482  1.000 33.84699  ?  476  THR A O   1 
ATOM   3626 C  CB  . THR A 1 476 ? -8.02157  21.98131  29.74623  1.000 37.48961  ?  476  THR A CB  1 
ATOM   3627 O  OG1 . THR A 1 476 ? -7.80290  23.34365  30.11455  1.000 43.61626  ?  476  THR A OG1 1 
ATOM   3628 C  CG2 . THR A 1 476 ? -8.03009  21.85871  28.23546  1.000 36.81296  ?  476  THR A CG2 1 
ATOM   3629 N  N   . GLN A 1 477 ? -8.84232  20.88611  32.56671  1.000 34.93692  ?  477  GLN A N   1 
ATOM   3630 C  CA  . GLN A 1 477 ? -8.68156  21.00816  34.00150  1.000 35.22850  ?  477  GLN A CA  1 
ATOM   3631 C  C   . GLN A 1 477 ? -7.23737  21.33238  34.32834  1.000 32.28487  ?  477  GLN A C   1 
ATOM   3632 O  O   . GLN A 1 477 ? -6.31820  20.75960  33.74206  1.000 33.49234  ?  477  GLN A O   1 
ATOM   3633 C  CB  . GLN A 1 477 ? -9.07913  19.70986  34.69800  1.000 37.42161  ?  477  GLN A CB  1 
ATOM   3634 C  CG  . GLN A 1 477 ? -10.52631 19.34910  34.52985  1.000 34.15605  ?  477  GLN A CG  1 
ATOM   3635 C  CD  . GLN A 1 477 ? -10.88839 18.14584  35.34213  1.000 38.98356  ?  477  GLN A CD  1 
ATOM   3636 O  OE1 . GLN A 1 477 ? -10.62433 17.01098  34.93618  1.000 36.32060  ?  477  GLN A OE1 1 
ATOM   3637 N  NE2 . GLN A 1 477 ? -11.47960 18.37503  36.50552  1.000 35.63592  ?  477  GLN A NE2 1 
ATOM   3638 N  N   . SER A 1 478 ? -7.04849  22.25617  35.26775  1.000 36.35979  ?  478  SER A N   1 
ATOM   3639 C  CA  . SER A 1 478 ? -5.73522  22.52170  35.84408  1.000 36.99206  ?  478  SER A CA  1 
ATOM   3640 C  C   . SER A 1 478 ? -5.18589  21.26604  36.51805  1.000 31.04847  ?  478  SER A C   1 
ATOM   3641 O  O   . SER A 1 478 ? -5.93615  20.36529  36.90067  1.000 31.38845  ?  478  SER A O   1 
ATOM   3642 C  CB  . SER A 1 478 ? -5.82435  23.63725  36.88926  1.000 33.99805  ?  478  SER A CB  1 
ATOM   3643 O  OG  . SER A 1 478 ? -6.44792  23.12926  38.07400  1.000 35.17104  ?  478  SER A OG  1 
ATOM   3644 N  N   . TRP A 1 479 ? -3.85898  21.23334  36.69379  1.000 30.16672  ?  479  TRP A N   1 
ATOM   3645 C  CA  . TRP A 1 479 ? -3.25368  20.16331  37.47584  1.000 34.16547  ?  479  TRP A CA  1 
ATOM   3646 C  C   . TRP A 1 479 ? -3.74110  20.16907  38.92644  1.000 34.61531  ?  479  TRP A C   1 
ATOM   3647 O  O   . TRP A 1 479 ? -3.91413  19.09873  39.52663  1.000 31.82631  ?  479  TRP A O   1 
ATOM   3648 C  CB  . TRP A 1 479 ? -1.73480  20.24950  37.39314  1.000 29.01200  ?  479  TRP A CB  1 
ATOM   3649 C  CG  . TRP A 1 479 ? -1.25507  19.85226  36.02402  1.000 34.19486  ?  479  TRP A CG  1 
ATOM   3650 C  CD1 . TRP A 1 479 ? -0.52384  20.61245  35.14701  1.000 30.09584  ?  479  TRP A CD1 1 
ATOM   3651 C  CD2 . TRP A 1 479 ? -1.49917  18.59528  35.36244  1.000 31.90675  ?  479  TRP A CD2 1 
ATOM   3652 N  NE1 . TRP A 1 479 ? -0.31123  19.90181  33.98407  1.000 35.71206  ?  479  TRP A NE1 1 
ATOM   3653 C  CE2 . TRP A 1 479 ? -0.90190  18.66597  34.09648  1.000 33.50312  ?  479  TRP A CE2 1 
ATOM   3654 C  CE3 . TRP A 1 479 ? -2.17394  17.42670  35.72406  1.000 34.39198  ?  479  TRP A CE3 1 
ATOM   3655 C  CZ2 . TRP A 1 479 ? -0.94080  17.60729  33.19667  1.000 34.24744  ?  479  TRP A CZ2 1 
ATOM   3656 C  CZ3 . TRP A 1 479 ? -2.22456  16.37970  34.82197  1.000 35.68135  ?  479  TRP A CZ3 1 
ATOM   3657 C  CH2 . TRP A 1 479 ? -1.60318  16.47497  33.57821  1.000 35.63938  ?  479  TRP A CH2 1 
ATOM   3658 N  N   . GLN A 1 480 ? -4.01706  21.34228  39.49867  1.000 33.61020  ?  480  GLN A N   1 
ATOM   3659 C  CA  . GLN A 1 480 ? -4.49839  21.34213  40.87606  1.000 34.82296  ?  480  GLN A CA  1 
ATOM   3660 C  C   . GLN A 1 480 ? -5.87701  20.71598  40.96985  1.000 33.22960  ?  480  GLN A C   1 
ATOM   3661 O  O   . GLN A 1 480 ? -6.16962  19.99703  41.92538  1.000 32.89564  ?  480  GLN A O   1 
ATOM   3662 C  CB  . GLN A 1 480 ? -4.52700  22.75364  41.46118  1.000 34.67997  ?  480  GLN A CB  1 
ATOM   3663 C  CG  . GLN A 1 480 ? -4.69051  22.78675  42.99354  1.000 31.40391  ?  480  GLN A CG  1 
ATOM   3664 C  CD  . GLN A 1 480 ? -3.62906  21.98078  43.74645  1.000 30.10633  ?  480  GLN A CD  1 
ATOM   3665 O  OE1 . GLN A 1 480 ? -2.46690  22.36055  43.78759  1.000 32.92734  ?  480  GLN A OE1 1 
ATOM   3666 N  NE2 . GLN A 1 480 ? -4.04184  20.88089  44.36783  1.000 30.32256  ?  480  GLN A NE2 1 
ATOM   3667 N  N   . LYS A 1 481 ? -6.72627  20.96875  39.98141  1.000 33.32698  ?  481  LYS A N   1 
ATOM   3668 C  CA  . LYS A 1 481 ? -8.08425  20.44353  39.99513  1.000 29.69140  ?  481  LYS A CA  1 
ATOM   3669 C  C   . LYS A 1 481 ? -8.09067  18.93232  39.83820  1.000 31.41590  ?  481  LYS A C   1 
ATOM   3670 O  O   . LYS A 1 481 ? -8.83827  18.22778  40.53392  1.000 33.28193  ?  481  LYS A O   1 
ATOM   3671 C  CB  . LYS A 1 481 ? -8.90069  21.11808  38.88644  1.000 36.17163  ?  481  LYS A CB  1 
ATOM   3672 C  CG  . LYS A 1 481 ? -9.99159  22.06743  39.39783  1.000 45.05018  ?  481  LYS A CG  1 
ATOM   3673 C  CD  . LYS A 1 481 ? -9.47752  23.00704  40.49801  1.000 46.59832  ?  481  LYS A CD  1 
ATOM   3674 C  CE  . LYS A 1 481 ? -10.59290 23.90596  41.05383  1.000 53.29877  ?  481  LYS A CE  1 
ATOM   3675 N  NZ  . LYS A 1 481 ? -11.71769 23.12463  41.66079  1.000 57.94634  ?  481  LYS A NZ  1 
ATOM   3676 N  N   . ILE A 1 482 ? -7.23573  18.41463  38.95517  1.000 33.04619  ?  482  ILE A N   1 
ATOM   3677 C  CA  . ILE A 1 482 ? -7.09379  16.96980  38.80551  1.000 29.48525  ?  482  ILE A CA  1 
ATOM   3678 C  C   . ILE A 1 482 ? -6.53350  16.34651  40.07846  1.000 31.85641  ?  482  ILE A C   1 
ATOM   3679 O  O   . ILE A 1 482 ? -6.99219  15.28286  40.51620  1.000 30.26448  ?  482  ILE A O   1 
ATOM   3680 C  CB  . ILE A 1 482 ? -6.20302  16.65649  37.59550  1.000 33.15358  ?  482  ILE A CB  1 
ATOM   3681 C  CG1 . ILE A 1 482 ? -6.82661  17.19310  36.32835  1.000 29.19260  ?  482  ILE A CG1 1 
ATOM   3682 C  CG2 . ILE A 1 482 ? -5.94301  15.14140  37.44973  1.000 29.02721  ?  482  ILE A CG2 1 
ATOM   3683 C  CD1 . ILE A 1 482 ? -5.77952  17.36303  35.27510  1.000 35.73055  ?  482  ILE A CD1 1 
ATOM   3684 N  N   . ALA A 1 483 ? -5.51616  16.97962  40.67656  1.000 31.31522  ?  483  ALA A N   1 
ATOM   3685 C  CA  . ALA A 1 483 ? -4.97012  16.46708  41.93246  1.000 31.54227  ?  483  ALA A CA  1 
ATOM   3686 C  C   . ALA A 1 483 ? -6.02944  16.48183  43.03145  1.000 31.98945  ?  483  ALA A C   1 
ATOM   3687 O  O   . ALA A 1 483 ? -6.09966  15.55978  43.84408  1.000 33.26288  ?  483  ALA A O   1 
ATOM   3688 C  CB  . ALA A 1 483 ? -3.74103  17.27584  42.34839  1.000 27.85788  ?  483  ALA A CB  1 
ATOM   3689 N  N   . ASP A 1 484 ? -6.89253  17.49610  43.04661  1.000 30.21467  ?  484  ASP A N   1 
ATOM   3690 C  CA  . ASP A 1 484 ? -7.94646  17.52164  44.04797  1.000 31.53147  ?  484  ASP A CA  1 
ATOM   3691 C  C   . ASP A 1 484 ? -8.90813  16.36058  43.84294  1.000 35.00718  ?  484  ASP A C   1 
ATOM   3692 O  O   . ASP A 1 484 ? -9.34703  15.72779  44.81573  1.000 32.70894  ?  484  ASP A O   1 
ATOM   3693 C  CB  . ASP A 1 484 ? -8.69579  18.85327  43.99504  1.000 32.68904  ?  484  ASP A CB  1 
ATOM   3694 C  CG  . ASP A 1 484 ? -7.85154  20.02104  44.44972  1.000 39.06193  ?  484  ASP A CG  1 
ATOM   3695 O  OD1 . ASP A 1 484 ? -6.69606  19.80401  44.91176  1.000 38.66612  -1 484  ASP A OD1 1 
ATOM   3696 O  OD2 . ASP A 1 484 ? -8.35722  21.17831  44.35978  1.000 45.08837  -1 484  ASP A OD2 1 
ATOM   3697 N  N   . GLU A 1 485 ? -9.25175  16.06627  42.57668  1.000 30.81208  ?  485  GLU A N   1 
ATOM   3698 C  CA  . GLU A 1 485 ? -10.13363 14.93032  42.31702  1.000 35.59841  ?  485  GLU A CA  1 
ATOM   3699 C  C   . GLU A 1 485 ? -9.47154  13.62602  42.74908  1.000 32.40995  ?  485  GLU A C   1 
ATOM   3700 O  O   . GLU A 1 485 ? -10.12157 12.75523  43.33643  1.000 31.59169  ?  485  GLU A O   1 
ATOM   3701 C  CB  . GLU A 1 485 ? -10.50764 14.85860  40.83554  1.000 34.08851  ?  485  GLU A CB  1 
ATOM   3702 C  CG  . GLU A 1 485 ? -11.51933 15.86974  40.36886  1.000 34.93057  ?  485  GLU A CG  1 
ATOM   3703 C  CD  . GLU A 1 485 ? -12.07726 15.51855  38.97400  1.000 45.87818  ?  485  GLU A CD  1 
ATOM   3704 O  OE1 . GLU A 1 485 ? -12.01374 14.32834  38.53823  1.000 39.49010  ?  485  GLU A OE1 1 
ATOM   3705 O  OE2 . GLU A 1 485 ? -12.60215 16.43775  38.32580  1.000 45.61195  -1 485  GLU A OE2 1 
ATOM   3706 N  N   . ILE A 1 486 ? -8.16767  13.48332  42.47709  1.000 32.00626  ?  486  ILE A N   1 
ATOM   3707 C  CA  . ILE A 1 486 ? -7.45829  12.25903  42.85229  1.000 32.84945  ?  486  ILE A CA  1 
ATOM   3708 C  C   . ILE A 1 486 ? -7.39019  12.11864  44.37635  1.000 32.03968  ?  486  ILE A C   1 
ATOM   3709 O  O   . ILE A 1 486 ? -7.67534  11.05045  44.93692  1.000 34.86106  ?  486  ILE A O   1 
ATOM   3710 C  CB  . ILE A 1 486 ? -6.05984  12.23875  42.20559  1.000 29.47684  ?  486  ILE A CB  1 
ATOM   3711 C  CG1 . ILE A 1 486 ? -6.17897  12.07900  40.68311  1.000 32.06871  ?  486  ILE A CG1 1 
ATOM   3712 C  CG2 . ILE A 1 486 ? -5.19882  11.12236  42.79920  1.000 24.73371  ?  486  ILE A CG2 1 
ATOM   3713 C  CD1 . ILE A 1 486 ? -5.00496  12.68661  39.83794  1.000 25.51241  ?  486  ILE A CD1 1 
ATOM   3714 N  N   . ALA A 1 487 ? -7.04271  13.20591  45.06772  1.000 32.43861  ?  487  ALA A N   1 
ATOM   3715 C  CA  . ALA A 1 487 ? -6.83966  13.19261  46.51319  1.000 33.80983  ?  487  ALA A CA  1 
ATOM   3716 C  C   . ALA A 1 487 ? -8.13131  12.96300  47.29142  1.000 35.64417  ?  487  ALA A C   1 
ATOM   3717 O  O   . ALA A 1 487 ? -8.08080  12.66324  48.49360  1.000 32.96364  ?  487  ALA A O   1 
ATOM   3718 C  CB  . ALA A 1 487 ? -6.20726  14.51464  46.96035  1.000 33.26933  ?  487  ALA A CB  1 
ATOM   3719 N  N   . ALA A 1 488 ? -9.28842  13.11612  46.64558  1.000 35.26621  ?  488  ALA A N   1 
ATOM   3720 C  CA  . ALA A 1 488 ? -10.54275 12.80112  47.30676  1.000 30.15790  ?  488  ALA A CA  1 
ATOM   3721 C  C   . ALA A 1 488 ? -10.78568 11.30693  47.40160  1.000 31.49794  ?  488  ALA A C   1 
ATOM   3722 O  O   . ALA A 1 488 ? -11.81167 10.91748  47.97247  1.000 32.58928  ?  488  ALA A O   1 
ATOM   3723 C  CB  . ALA A 1 488 ? -11.71562 13.46499  46.57410  1.000 28.77961  ?  488  ALA A CB  1 
ATOM   3724 N  N   . ARG A 1 489 ? -9.87446  10.47951  46.85130  1.000 31.26790  ?  489  ARG A N   1 
ATOM   3725 C  CA  . ARG A 1 489 ? -10.02915 9.04948   46.63557  1.000 31.55959  ?  489  ARG A CA  1 
ATOM   3726 C  C   . ARG A 1 489 ? -8.93663  8.24640   47.34401  1.000 28.32396  ?  489  ARG A C   1 
ATOM   3727 O  O   . ARG A 1 489 ? -7.78214  8.69007   47.41599  1.000 31.31908  ?  489  ARG A O   1 
ATOM   3728 C  CB  . ARG A 1 489 ? -9.98740  8.72976   45.13876  1.000 32.50726  ?  489  ARG A CB  1 
ATOM   3729 C  CG  . ARG A 1 489 ? -11.22422 9.07876   44.37116  1.000 28.43665  ?  489  ARG A CG  1 
ATOM   3730 C  CD  . ARG A 1 489 ? -10.92126 9.09610   42.85483  1.000 30.83341  ?  489  ARG A CD  1 
ATOM   3731 N  NE  . ARG A 1 489 ? -12.16026 9.01739   42.09595  1.000 35.44901  ?  489  ARG A NE  1 
ATOM   3732 C  CZ  . ARG A 1 489 ? -12.97773 10.04594  41.91902  1.000 41.31540  ?  489  ARG A CZ  1 
ATOM   3733 N  NH1 . ARG A 1 489 ? -12.68110 11.25675  42.38582  1.000 31.11848  ?  489  ARG A NH1 1 
ATOM   3734 N  NH2 . ARG A 1 489 ? -14.12485 9.85448   41.27800  1.000 38.33938  ?  489  ARG A NH2 1 
ATOM   3735 N  N   . PRO A 1 490 ? -9.26072  7.05940   47.86111  1.000 24.28810  ?  490  PRO A N   1 
ATOM   3736 C  CA  . PRO A 1 490 ? -8.29186  6.35599   48.72286  1.000 26.44268  ?  490  PRO A CA  1 
ATOM   3737 C  C   . PRO A 1 490 ? -7.10988  5.73603   47.98106  1.000 25.03302  ?  490  PRO A C   1 
ATOM   3738 O  O   . PRO A 1 490 ? -6.05934  5.54200   48.59811  1.000 27.74701  ?  490  PRO A O   1 
ATOM   3739 C  CB  . PRO A 1 490 ? -9.14418  5.28182   49.40979  1.000 24.77001  ?  490  PRO A CB  1 
ATOM   3740 C  CG  . PRO A 1 490 ? -10.34407 5.09522   48.51404  1.000 27.88145  ?  490  PRO A CG  1 
ATOM   3741 C  CD  . PRO A 1 490 ? -10.60149 6.43604   47.90230  1.000 25.11215  ?  490  PRO A CD  1 
ATOM   3742 N  N   . CYS A 1 491 ? -7.22411  5.44078   46.69138  1.000 25.59331  ?  491  CYS A N   1 
ATOM   3743 C  CA  . CYS A 1 491 ? -6.19797  4.65031   46.01976  1.000 30.62486  ?  491  CYS A CA  1 
ATOM   3744 C  C   . CYS A 1 491 ? -6.32321  4.87327   44.51919  1.000 27.89739  ?  491  CYS A C   1 
ATOM   3745 O  O   . CYS A 1 491 ? -7.29697  4.42049   43.91818  1.000 30.19433  ?  491  CYS A O   1 
ATOM   3746 C  CB  . CYS A 1 491 ? -6.36366  3.17306   46.37717  1.000 25.58151  ?  491  CYS A CB  1 
ATOM   3747 S  SG  . CYS A 1 491 ? -5.06534  2.07372   45.73994  1.000 34.56735  ?  491  CYS A SG  1 
ATOM   3748 N  N   . VAL A 1 492 ? -5.35558  5.54924   43.91164  1.000 25.00291  ?  492  VAL A N   1 
ATOM   3749 C  CA  . VAL A 1 492 ? -5.48124  5.96344   42.51523  1.000 26.00670  ?  492  VAL A CA  1 
ATOM   3750 C  C   . VAL A 1 492 ? -4.14742  5.80354   41.80598  1.000 28.95576  ?  492  VAL A C   1 
ATOM   3751 O  O   . VAL A 1 492 ? -3.11572  6.27721   42.28944  1.000 27.76337  ?  492  VAL A O   1 
ATOM   3752 C  CB  . VAL A 1 492 ? -5.95019  7.42445   42.37767  1.000 31.41638  ?  492  VAL A CB  1 
ATOM   3753 C  CG1 . VAL A 1 492 ? -6.01689  7.84915   40.88878  1.000 27.41057  ?  492  VAL A CG1 1 
ATOM   3754 C  CG2 . VAL A 1 492 ? -7.27843  7.67173   43.12846  1.000 22.89390  ?  492  VAL A CG2 1 
ATOM   3755 N  N   . LEU A 1 493 ? -4.17173  5.16322   40.64506  1.000 31.71114  ?  493  LEU A N   1 
ATOM   3756 C  CA  . LEU A 1 493 ? -3.08355  5.24570   39.68716  1.000 29.02511  ?  493  LEU A CA  1 
ATOM   3757 C  C   . LEU A 1 493 ? -3.46205  6.29204   38.64656  1.000 27.00296  ?  493  LEU A C   1 
ATOM   3758 O  O   . LEU A 1 493 ? -4.46924  6.13847   37.95787  1.000 28.50094  ?  493  LEU A O   1 
ATOM   3759 C  CB  . LEU A 1 493 ? -2.83357  3.88982   39.02255  1.000 32.30690  ?  493  LEU A CB  1 
ATOM   3760 C  CG  . LEU A 1 493 ? -2.08237  3.95762   37.68753  1.000 29.06334  ?  493  LEU A CG  1 
ATOM   3761 C  CD1 . LEU A 1 493 ? -0.67143  4.47976   37.91184  1.000 27.97106  ?  493  LEU A CD1 1 
ATOM   3762 C  CD2 . LEU A 1 493 ? -2.04517  2.61995   36.96834  1.000 24.20756  ?  493  LEU A CD2 1 
ATOM   3763 N  N   . ALA A 1 494 ? -2.64831  7.33724   38.52438  1.000 28.56154  ?  494  ALA A N   1 
ATOM   3764 C  CA  . ALA A 1 494 ? -2.86093  8.40580   37.55663  1.000 29.39063  ?  494  ALA A CA  1 
ATOM   3765 C  C   . ALA A 1 494 ? -1.79875  8.33386   36.46602  1.000 23.72447  ?  494  ALA A C   1 
ATOM   3766 O  O   . ALA A 1 494 ? -0.60286  8.35183   36.75986  1.000 26.93420  ?  494  ALA A O   1 
ATOM   3767 C  CB  . ALA A 1 494 ? -2.81365  9.78626   38.22589  1.000 28.50417  ?  494  ALA A CB  1 
ATOM   3768 N  N   . VAL A 1 495 ? -2.23163  8.29710   35.21342  1.000 26.48197  ?  495  VAL A N   1 
ATOM   3769 C  CA  . VAL A 1 495 ? -1.31978  8.20187   34.07900  1.000 30.61143  ?  495  VAL A CA  1 
ATOM   3770 C  C   . VAL A 1 495 ? -1.40431  9.46924   33.22353  1.000 29.55764  ?  495  VAL A C   1 
ATOM   3771 O  O   . VAL A 1 495 ? -2.49626  9.89113   32.82079  1.000 27.39675  ?  495  VAL A O   1 
ATOM   3772 C  CB  . VAL A 1 495 ? -1.62598  6.95434   33.25018  1.000 31.67504  ?  495  VAL A CB  1 
ATOM   3773 C  CG1 . VAL A 1 495 ? -0.74978  6.92634   32.00209  1.000 33.18803  ?  495  VAL A CG1 1 
ATOM   3774 C  CG2 . VAL A 1 495 ? -1.35412  5.75068   34.10019  1.000 35.57893  ?  495  VAL A CG2 1 
ATOM   3775 N  N   . VAL A 1 496 ? -0.25165  10.07568  32.95398  1.000 29.86494  ?  496  VAL A N   1 
ATOM   3776 C  CA  . VAL A 1 496 ? -0.18681  11.33032  32.20448  1.000 31.95821  ?  496  VAL A CA  1 
ATOM   3777 C  C   . VAL A 1 496 ? 0.72670   11.13357  30.99303  1.000 32.37710  ?  496  VAL A C   1 
ATOM   3778 O  O   . VAL A 1 496 ? 1.39192   10.10502  30.84303  1.000 35.31862  ?  496  VAL A O   1 
ATOM   3779 C  CB  . VAL A 1 496 ? 0.28387   12.49770  33.07839  1.000 31.11546  ?  496  VAL A CB  1 
ATOM   3780 C  CG1 . VAL A 1 496 ? -0.69947  12.70421  34.23454  1.000 29.30279  ?  496  VAL A CG1 1 
ATOM   3781 C  CG2 . VAL A 1 496 ? 1.66977   12.21877  33.63838  1.000 30.52076  ?  496  VAL A CG2 1 
ATOM   3782 N  N   . ASN A 1 497 ? 0.71810   12.11456  30.10041  1.000 31.15519  ?  497  ASN A N   1 
ATOM   3783 C  CA  . ASN A 1 497 ? 1.30313   11.92592  28.77455  1.000 33.12931  ?  497  ASN A CA  1 
ATOM   3784 C  C   . ASN A 1 497 ? 2.74325   12.41834  28.62435  1.000 34.91823  ?  497  ASN A C   1 
ATOM   3785 O  O   . ASN A 1 497 ? 3.34727   12.15189  27.58130  1.000 40.40732  ?  497  ASN A O   1 
ATOM   3786 C  CB  . ASN A 1 497 ? 0.42648   12.61040  27.71690  1.000 35.07255  ?  497  ASN A CB  1 
ATOM   3787 C  CG  . ASN A 1 497 ? -0.90171  11.93977  27.56681  1.000 31.10693  ?  497  ASN A CG  1 
ATOM   3788 O  OD1 . ASN A 1 497 ? -0.99253  10.70573  27.61261  1.000 39.89130  ?  497  ASN A OD1 1 
ATOM   3789 N  ND2 . ASN A 1 497 ? -1.95019  12.73045  27.43376  1.000 34.49309  ?  497  ASN A ND2 1 
ATOM   3790 N  N   . THR A 1 498 ? 3.31359   13.12228  29.60447  1.000 30.37701  ?  498  THR A N   1 
ATOM   3791 C  CA  . THR A 1 498 ? 4.71126   13.55238  29.52373  1.000 35.69264  ?  498  THR A CA  1 
ATOM   3792 C  C   . THR A 1 498 ? 5.33230   13.56444  30.91503  1.000 32.90028  ?  498  THR A C   1 
ATOM   3793 O  O   . THR A 1 498 ? 4.62072   13.59597  31.91646  1.000 31.12520  ?  498  THR A O   1 
ATOM   3794 C  CB  . THR A 1 498 ? 4.88411   14.96059  28.92456  1.000 33.64183  ?  498  THR A CB  1 
ATOM   3795 O  OG1 . THR A 1 498 ? 4.54249   15.93002  29.91104  1.000 37.86174  ?  498  THR A OG1 1 
ATOM   3796 C  CG2 . THR A 1 498 ? 4.04698   15.18552  27.65218  1.000 37.22797  ?  498  THR A CG2 1 
ATOM   3797 N  N   . ARG A 1 499 ? 6.67965   13.58724  30.95328  1.000 32.19731  ?  499  ARG A N   1 
ATOM   3798 C  CA  . ARG A 1 499 ? 7.43099   13.64305  32.21368  1.000 31.70441  ?  499  ARG A CA  1 
ATOM   3799 C  C   . ARG A 1 499 ? 7.13858   14.91685  33.00491  1.000 34.64014  ?  499  ARG A C   1 
ATOM   3800 O  O   . ARG A 1 499 ? 7.05624   14.89010  34.24484  1.000 36.45198  ?  499  ARG A O   1 
ATOM   3801 C  CB  . ARG A 1 499 ? 8.93639   13.55058  31.94835  1.000 36.18674  ?  499  ARG A CB  1 
ATOM   3802 C  CG  . ARG A 1 499 ? 9.35992   12.49480  30.97675  1.000 36.42322  ?  499  ARG A CG  1 
ATOM   3803 C  CD  . ARG A 1 499 ? 10.76251  12.74272  30.47917  1.000 36.40671  ?  499  ARG A CD  1 
ATOM   3804 N  NE  . ARG A 1 499 ? 11.12470  11.71677  29.50582  1.000 40.17950  ?  499  ARG A NE  1 
ATOM   3805 C  CZ  . ARG A 1 499 ? 12.35022  11.24880  29.30095  1.000 36.38614  ?  499  ARG A CZ  1 
ATOM   3806 N  NH1 . ARG A 1 499 ? 13.38544  11.67028  30.00687  1.000 39.22963  ?  499  ARG A NH1 1 
ATOM   3807 N  NH2 . ARG A 1 499 ? 12.54410  10.34133  28.35482  1.000 40.30534  ?  499  ARG A NH2 1 
ATOM   3808 N  N   . LYS A 1 500 ? 7.03544   16.05115  32.31580  1.000 36.03639  ?  500  LYS A N   1 
ATOM   3809 C  CA  . LYS A 1 500 ? 6.74506   17.29647  33.01550  1.000 38.40107  ?  500  LYS A CA  1 
ATOM   3810 C  C   . LYS A 1 500 ? 5.35445   17.25365  33.62385  1.000 31.48002  ?  500  LYS A C   1 
ATOM   3811 O  O   . LYS A 1 500 ? 5.13191   17.76861  34.72316  1.000 30.77847  ?  500  LYS A O   1 
ATOM   3812 C  CB  . LYS A 1 500 ? 6.87299   18.49341  32.06628  1.000 42.12993  ?  500  LYS A CB  1 
ATOM   3813 C  CG  . LYS A 1 500 ? 8.28904   18.78108  31.59026  1.000 44.51204  ?  500  LYS A CG  1 
ATOM   3814 C  CD  . LYS A 1 500 ? 9.07124   19.57060  32.62312  1.000 50.51068  ?  500  LYS A CD  1 
ATOM   3815 C  CE  . LYS A 1 500 ? 10.57453  19.56778  32.31655  1.000 55.34104  ?  500  LYS A CE  1 
ATOM   3816 N  NZ  . LYS A 1 500 ? 11.35658  19.82896  33.56735  1.000 57.57799  ?  500  LYS A NZ  1 
ATOM   3817 N  N   . HIS A 1 501 ? 4.40525   16.65829  32.90865  1.000 33.22511  ?  501  HIS A N   1 
ATOM   3818 C  CA  . HIS A 1 501 ? 3.06927   16.48971  33.45645  1.000 32.44427  ?  501  HIS A CA  1 
ATOM   3819 C  C   . HIS A 1 501 ? 3.10908   15.61951  34.70840  1.000 34.26546  ?  501  HIS A C   1 
ATOM   3820 O  O   . HIS A 1 501 ? 2.40200   15.88493  35.68924  1.000 30.41668  ?  501  HIS A O   1 
ATOM   3821 C  CB  . HIS A 1 501 ? 2.16138   15.89094  32.38840  1.000 34.56436  ?  501  HIS A CB  1 
ATOM   3822 C  CG  . HIS A 1 501 ? 1.89270   16.82116  31.24650  1.000 36.44853  ?  501  HIS A CG  1 
ATOM   3823 N  ND1 . HIS A 1 501 ? 1.04907   16.50008  30.20446  1.000 40.02435  ?  501  HIS A ND1 1 
ATOM   3824 C  CD2 . HIS A 1 501 ? 2.34549   18.07228  30.99301  1.000 35.64149  ?  501  HIS A CD2 1 
ATOM   3825 C  CE1 . HIS A 1 501 ? 1.01016   17.50610  29.34701  1.000 41.26963  ?  501  HIS A CE1 1 
ATOM   3826 N  NE2 . HIS A 1 501 ? 1.78468   18.47291  29.80494  1.000 38.87287  ?  501  HIS A NE2 1 
ATOM   3827 N  N   . ALA A 1 502 ? 3.93981   14.57894  34.69721  1.000 28.09570  ?  502  ALA A N   1 
ATOM   3828 C  CA  . ALA A 1 502 ? 4.07612   13.75932  35.89285  1.000 31.72055  ?  502  ALA A CA  1 
ATOM   3829 C  C   . ALA A 1 502 ? 4.59467   14.58745  37.05547  1.000 32.35724  ?  502  ALA A C   1 
ATOM   3830 O  O   . ALA A 1 502 ? 4.08623   14.48204  38.18070  1.000 32.60830  ?  502  ALA A O   1 
ATOM   3831 C  CB  . ALA A 1 502 ? 4.99778   12.58141  35.61340  1.000 26.50406  ?  502  ALA A CB  1 
ATOM   3832 N  N   . GLN A 1 503 ? 5.60562   15.42589  36.80618  1.000 34.40620  ?  503  GLN A N   1 
ATOM   3833 C  CA  . GLN A 1 503 ? 6.11578   16.27009  37.87868  1.000 27.51803  ?  503  GLN A CA  1 
ATOM   3834 C  C   . GLN A 1 503 ? 5.04451   17.22870  38.38026  1.000 27.86534  ?  503  GLN A C   1 
ATOM   3835 O  O   . GLN A 1 503 ? 4.86665   17.39551  39.59246  1.000 31.88277  ?  503  GLN A O   1 
ATOM   3836 C  CB  . GLN A 1 503 ? 7.32938   17.04912  37.40437  1.000 33.48965  ?  503  GLN A CB  1 
ATOM   3837 C  CG  . GLN A 1 503 ? 8.50334   16.22244  37.04414  1.000 37.88125  ?  503  GLN A CG  1 
ATOM   3838 C  CD  . GLN A 1 503 ? 9.65948   17.09705  36.61748  1.000 43.64780  ?  503  GLN A CD  1 
ATOM   3839 O  OE1 . GLN A 1 503 ? 9.49031   18.30055  36.39392  1.000 51.08077  ?  503  GLN A OE1 1 
ATOM   3840 N  NE2 . GLN A 1 503 ? 10.83825  16.51201  36.52515  1.000 49.67596  ?  503  GLN A NE2 1 
ATOM   3841 N  N   . LYS A 1 504 ? 4.31844   17.88040  37.46450  1.000 30.17469  ?  504  LYS A N   1 
ATOM   3842 C  CA  . LYS A 1 504 ? 3.32135   18.86458  37.90088  1.000 32.61024  ?  504  LYS A CA  1 
ATOM   3843 C  C   . LYS A 1 504 ? 2.20146   18.19725  38.68958  1.000 33.08209  ?  504  LYS A C   1 
ATOM   3844 O  O   . LYS A 1 504 ? 1.75397   18.71584  39.72172  1.000 32.23361  ?  504  LYS A O   1 
ATOM   3845 C  CB  . LYS A 1 504 ? 2.74713   19.62290  36.70443  1.000 33.18604  ?  504  LYS A CB  1 
ATOM   3846 C  CG  . LYS A 1 504 ? 3.75684   20.51827  35.94579  1.000 31.48861  ?  504  LYS A CG  1 
ATOM   3847 C  CD  . LYS A 1 504 ? 3.01204   21.58110  35.13059  1.000 37.75037  ?  504  LYS A CD  1 
ATOM   3848 C  CE  . LYS A 1 504 ? 3.69323   21.89931  33.81044  1.000 41.73359  ?  504  LYS A CE  1 
ATOM   3849 N  NZ  . LYS A 1 504 ? 5.07554   22.42725  33.99079  1.000 52.26473  ?  504  LYS A NZ  1 
ATOM   3850 N  N   . LEU A 1 505 ? 1.73599   17.03355  38.23236  1.000 32.51403  ?  505  LEU A N   1 
ATOM   3851 C  CA  . LEU A 1 505 ? 0.65545   16.38795  38.95576  1.000 29.61575  ?  505  LEU A CA  1 
ATOM   3852 C  C   . LEU A 1 505 ? 1.13391   15.92042  40.32223  1.000 31.45872  ?  505  LEU A C   1 
ATOM   3853 O  O   . LEU A 1 505 ? 0.46149   16.15695  41.33582  1.000 30.87367  ?  505  LEU A O   1 
ATOM   3854 C  CB  . LEU A 1 505 ? 0.08211   15.23567  38.14642  1.000 28.94044  ?  505  LEU A CB  1 
ATOM   3855 C  CG  . LEU A 1 505 ? -1.09046  14.52308  38.84836  1.000 30.20564  ?  505  LEU A CG  1 
ATOM   3856 C  CD1 . LEU A 1 505 ? -2.11396  15.49810  39.36227  1.000 24.13089  ?  505  LEU A CD1 1 
ATOM   3857 C  CD2 . LEU A 1 505 ? -1.74462  13.47493  37.89317  1.000 25.89941  ?  505  LEU A CD2 1 
ATOM   3858 N  N   . PHE A 1 506 ? 2.30982   15.27691  40.36830  1.000 32.48259  ?  506  PHE A N   1 
ATOM   3859 C  CA  . PHE A 1 506 ? 2.87196   14.82967  41.63723  1.000 33.21552  ?  506  PHE A CA  1 
ATOM   3860 C  C   . PHE A 1 506 ? 3.01122   15.99081  42.61495  1.000 32.36633  ?  506  PHE A C   1 
ATOM   3861 O  O   . PHE A 1 506 ? 2.66470   15.87155  43.79483  1.000 33.01822  ?  506  PHE A O   1 
ATOM   3862 C  CB  . PHE A 1 506 ? 4.23653   14.17043  41.39162  1.000 30.97948  ?  506  PHE A CB  1 
ATOM   3863 C  CG  . PHE A 1 506 ? 4.86873   13.58201  42.63623  1.000 36.22722  ?  506  PHE A CG  1 
ATOM   3864 C  CD1 . PHE A 1 506 ? 4.52800   12.29469  43.06852  1.000 31.57331  ?  506  PHE A CD1 1 
ATOM   3865 C  CD2 . PHE A 1 506 ? 5.80959   14.31184  43.37725  1.000 33.26155  ?  506  PHE A CD2 1 
ATOM   3866 C  CE1 . PHE A 1 506 ? 5.11676   11.73866  44.21935  1.000 30.69813  ?  506  PHE A CE1 1 
ATOM   3867 C  CE2 . PHE A 1 506 ? 6.38147   13.75941  44.52708  1.000 39.34798  ?  506  PHE A CE2 1 
ATOM   3868 C  CZ  . PHE A 1 506 ? 6.04226   12.47495  44.93585  1.000 28.83170  ?  506  PHE A CZ  1 
ATOM   3869 N  N   . ALA A 1 507 ? 3.57168   17.10703  42.15293  1.000 32.50560  ?  507  ALA A N   1 
ATOM   3870 C  CA  . ALA A 1 507 ? 3.73199   18.25875  43.03714  1.000 38.22858  ?  507  ALA A CA  1 
ATOM   3871 C  C   . ALA A 1 507 ? 2.37750   18.75760  43.52534  1.000 32.54391  ?  507  ALA A C   1 
ATOM   3872 O  O   . ALA A 1 507 ? 2.23890   19.16718  44.68460  1.000 35.26280  ?  507  ALA A O   1 
ATOM   3873 C  CB  . ALA A 1 507 ? 4.50346   19.37085  42.32195  1.000 29.95724  ?  507  ALA A CB  1 
ATOM   3874 N  N   . ALA A 1 508 ? 1.35724   18.69658  42.66751  1.000 32.01976  ?  508  ALA A N   1 
ATOM   3875 C  CA  . ALA A 1 508 ? 0.04887   19.23631  43.03754  1.000 29.59319  ?  508  ALA A CA  1 
ATOM   3876 C  C   . ALA A 1 508 ? -0.64693  18.41914  44.12498  1.000 32.37503  ?  508  ALA A C   1 
ATOM   3877 O  O   . ALA A 1 508 ? -1.53964  18.94459  44.80058  1.000 31.70585  ?  508  ALA A O   1 
ATOM   3878 C  CB  . ALA A 1 508 ? -0.84895  19.31831  41.79622  1.000 27.47747  ?  508  ALA A CB  1 
ATOM   3879 N  N   . LEU A 1 509 ? -0.28540  17.14444  44.29226  1.000 32.76865  ?  509  LEU A N   1 
ATOM   3880 C  CA  . LEU A 1 509 ? -0.96640  16.30222  45.26025  1.000 34.06990  ?  509  LEU A CA  1 
ATOM   3881 C  C   . LEU A 1 509 ? -0.62469  16.74457  46.69093  1.000 35.55028  ?  509  LEU A C   1 
ATOM   3882 O  O   . LEU A 1 509 ? 0.48316   17.22114  46.95527  1.000 32.57261  ?  509  LEU A O   1 
ATOM   3883 C  CB  . LEU A 1 509 ? -0.58211  14.83537  45.04313  1.000 32.19069  ?  509  LEU A CB  1 
ATOM   3884 C  CG  . LEU A 1 509 ? -1.26339  14.11326  43.85322  1.000 34.14850  ?  509  LEU A CG  1 
ATOM   3885 C  CD1 . LEU A 1 509 ? -0.55617  12.82115  43.53091  1.000 29.57724  ?  509  LEU A CD1 1 
ATOM   3886 C  CD2 . LEU A 1 509 ? -2.75960  13.85577  44.13398  1.000 28.76884  ?  509  LEU A CD2 1 
ATOM   3887 N  N   . PRO A 1 510 ? -1.56514  16.60944  47.62646  1.000 35.05139  ?  510  PRO A N   1 
ATOM   3888 C  CA  . PRO A 1 510 ? -1.28206  16.96618  49.02356  1.000 35.42442  ?  510  PRO A CA  1 
ATOM   3889 C  C   . PRO A 1 510 ? -0.24366  16.03433  49.63979  1.000 40.39191  ?  510  PRO A C   1 
ATOM   3890 O  O   . PRO A 1 510 ? 0.20589   15.04618  49.04604  1.000 39.48323  ?  510  PRO A O   1 
ATOM   3891 C  CB  . PRO A 1 510 ? -2.64757  16.83477  49.70947  1.000 40.19134  ?  510  PRO A CB  1 
ATOM   3892 C  CG  . PRO A 1 510 ? -3.41627  15.86426  48.84606  1.000 36.50843  ?  510  PRO A CG  1 
ATOM   3893 C  CD  . PRO A 1 510 ? -2.94803  16.12898  47.44306  1.000 28.70719  ?  510  PRO A CD  1 
ATOM   3894 N  N   . SER A 1 511 ? 0.17691   16.38730  50.85276  1.000 43.68689  ?  511  SER A N   1 
ATOM   3895 C  CA  . SER A 1 511 ? 1.25982   15.66688  51.50991  1.000 44.28467  ?  511  SER A CA  1 
ATOM   3896 C  C   . SER A 1 511 ? 0.76150   14.70996  52.58473  1.000 41.89473  ?  511  SER A C   1 
ATOM   3897 O  O   . SER A 1 511 ? 1.57336   14.09882  53.28304  1.000 43.87145  ?  511  SER A O   1 
ATOM   3898 C  CB  . SER A 1 511 ? 2.27759   16.65641  52.09005  1.000 45.40539  ?  511  SER A CB  1 
ATOM   3899 O  OG  . SER A 1 511 ? 1.62686   17.67556  52.81319  1.000 50.08216  ?  511  SER A OG  1 
ATOM   3900 N  N   . ASN A 1 512 ? -0.54566  14.53867  52.70510  1.000 41.19661  ?  512  ASN A N   1 
ATOM   3901 C  CA  . ASN A 1 512 ? -1.13243  13.64116  53.68445  1.000 44.46607  ?  512  ASN A CA  1 
ATOM   3902 C  C   . ASN A 1 512 ? -1.23620  12.20795  53.17162  1.000 43.23330  ?  512  ASN A C   1 
ATOM   3903 O  O   . ASN A 1 512 ? -1.65543  11.31917  53.91638  1.000 41.86404  ?  512  ASN A O   1 
ATOM   3904 C  CB  . ASN A 1 512 ? -2.52484  14.16309  54.08568  1.000 40.59260  ?  512  ASN A CB  1 
ATOM   3905 C  CG  . ASN A 1 512 ? -3.54289  13.99102  52.97473  1.000 46.99390  ?  512  ASN A CG  1 
ATOM   3906 O  OD1 . ASN A 1 512 ? -3.45583  14.65095  51.93270  1.000 41.00571  ?  512  ASN A OD1 1 
ATOM   3907 N  ND2 . ASN A 1 512 ? -4.52046  13.09032  53.18474  1.000 44.11399  ?  512  ASN A ND2 1 
ATOM   3908 N  N   . GLY A 1 513 ? -0.88400  11.95468  51.91420  1.000 43.34907  ?  513  GLY A N   1 
ATOM   3909 C  CA  . GLY A 1 513 ? -0.95172  10.62222  51.36062  1.000 39.57811  ?  513  GLY A CA  1 
ATOM   3910 C  C   . GLY A 1 513 ? 0.40725   9.94281   51.30273  1.000 38.50442  ?  513  GLY A C   1 
ATOM   3911 O  O   . GLY A 1 513 ? 1.42823   10.45587  51.76746  1.000 38.29179  ?  513  GLY A O   1 
ATOM   3912 N  N   . ILE A 1 514 ? 0.38304   8.73204   50.75960  1.000 30.68951  ?  514  ILE A N   1 
ATOM   3913 C  CA  . ILE A 1 514 ? 1.57689   8.04839   50.28310  1.000 22.87316  ?  514  ILE A CA  1 
ATOM   3914 C  C   . ILE A 1 514 ? 1.57220   8.22471   48.77201  1.000 32.64439  ?  514  ILE A C   1 
ATOM   3915 O  O   . ILE A 1 514 ? 0.76804   7.58964   48.07572  1.000 30.85616  ?  514  ILE A O   1 
ATOM   3916 C  CB  . ILE A 1 514 ? 1.56623   6.55643   50.66430  1.000 33.72059  ?  514  ILE A CB  1 
ATOM   3917 C  CG1 . ILE A 1 514 ? 1.48100   6.36970   52.19151  1.000 30.79822  ?  514  ILE A CG1 1 
ATOM   3918 C  CG2 . ILE A 1 514 ? 2.77237   5.81534   50.06583  1.000 26.97330  ?  514  ILE A CG2 1 
ATOM   3919 C  CD1 . ILE A 1 514 ? 0.95401   4.97599   52.62143  1.000 32.84698  ?  514  ILE A CD1 1 
ATOM   3920 N  N   . LYS A 1 515 ? 2.44551   9.08940   48.24414  1.000 34.00200  ?  515  LYS A N   1 
ATOM   3921 C  CA  . LYS A 1 515 ? 2.50315   9.32285   46.80457  1.000 35.41052  ?  515  LYS A CA  1 
ATOM   3922 C  C   . LYS A 1 515 ? 3.87088   8.92415   46.24467  1.000 30.83842  ?  515  LYS A C   1 
ATOM   3923 O  O   . LYS A 1 515 ? 4.89034   9.03810   46.92708  1.000 34.03587  ?  515  LYS A O   1 
ATOM   3924 C  CB  . LYS A 1 515 ? 2.16726   10.77496  46.46773  1.000 32.81427  ?  515  LYS A CB  1 
ATOM   3925 C  CG  . LYS A 1 515 ? 3.15213   11.82362  47.01117  1.000 33.44813  ?  515  LYS A CG  1 
ATOM   3926 C  CD  . LYS A 1 515 ? 2.54073   13.21187  46.80145  1.000 34.33063  ?  515  LYS A CD  1 
ATOM   3927 C  CE  . LYS A 1 515 ? 3.59458   14.30651  46.73121  1.000 38.10483  ?  515  LYS A CE  1 
ATOM   3928 N  NZ  . LYS A 1 515 ? 2.93617   15.64226  46.67737  1.000 35.49942  ?  515  LYS A NZ  1 
ATOM   3929 N  N   . LEU A 1 516 ? 3.86346   8.40710   45.01939  1.000 27.89828  ?  516  LEU A N   1 
ATOM   3930 C  CA  . LEU A 1 516 ? 5.03526   7.87086   44.32995  1.000 33.11573  ?  516  LEU A CA  1 
ATOM   3931 C  C   . LEU A 1 516 ? 4.97197   8.28190   42.85648  1.000 32.45003  ?  516  LEU A C   1 
ATOM   3932 O  O   . LEU A 1 516 ? 3.94462   8.75692   42.36263  1.000 28.67608  ?  516  LEU A O   1 
ATOM   3933 C  CB  . LEU A 1 516 ? 5.11839   6.34424   44.47408  1.000 35.91185  ?  516  LEU A CB  1 
ATOM   3934 C  CG  . LEU A 1 516 ? 5.37221   5.83932   45.90999  1.000 38.83118  ?  516  LEU A CG  1 
ATOM   3935 C  CD1 . LEU A 1 516 ? 4.92822   4.40509   46.11931  1.000 36.60670  ?  516  LEU A CD1 1 
ATOM   3936 C  CD2 . LEU A 1 516 ? 6.82693   5.96124   46.30042  1.000 33.21945  ?  516  LEU A CD2 1 
ATOM   3937 N  N   . HIS A 1 517 ? 6.08351   8.09971   42.14975  1.000 28.79799  ?  517  HIS A N   1 
ATOM   3938 C  CA  . HIS A 1 517 ? 6.29695   8.74659   40.86408  1.000 34.86130  ?  517  HIS A CA  1 
ATOM   3939 C  C   . HIS A 1 517 ? 7.09871   7.84142   39.96050  1.000 32.01892  ?  517  HIS A C   1 
ATOM   3940 O  O   . HIS A 1 517 ? 8.16515   7.37326   40.37174  1.000 31.39068  ?  517  HIS A O   1 
ATOM   3941 C  CB  . HIS A 1 517 ? 7.05333   10.08257  41.01142  1.000 31.96615  ?  517  HIS A CB  1 
ATOM   3942 C  CG  . HIS A 1 517 ? 7.56683   10.63912  39.71229  1.000 36.20070  ?  517  HIS A CG  1 
ATOM   3943 N  ND1 . HIS A 1 517 ? 8.81477   10.33338  39.20196  1.000 36.58754  ?  517  HIS A ND1 1 
ATOM   3944 C  CD2 . HIS A 1 517 ? 6.99587   11.48790  38.82059  1.000 32.16107  ?  517  HIS A CD2 1 
ATOM   3945 C  CE1 . HIS A 1 517 ? 8.98784   10.96805  38.05723  1.000 33.62561  ?  517  HIS A CE1 1 
ATOM   3946 N  NE2 . HIS A 1 517 ? 7.89766   11.67127  37.80064  1.000 33.46132  ?  517  HIS A NE2 1 
ATOM   3947 N  N   . LEU A 1 518 ? 6.59871   7.63831   38.73067  1.000 29.47330  ?  518  LEU A N   1 
ATOM   3948 C  CA  . LEU A 1 518 ? 7.28238   6.91127   37.66089  1.000 31.55132  ?  518  LEU A CA  1 
ATOM   3949 C  C   . LEU A 1 518 ? 7.26612   7.73305   36.38254  1.000 32.58883  ?  518  LEU A C   1 
ATOM   3950 O  O   . LEU A 1 518 ? 6.19365   8.14201   35.92676  1.000 31.58441  ?  518  LEU A O   1 
ATOM   3951 C  CB  . LEU A 1 518 ? 6.60246   5.57431   37.36969  1.000 36.47160  ?  518  LEU A CB  1 
ATOM   3952 C  CG  . LEU A 1 518 ? 6.71263   4.51790   38.45160  1.000 34.48941  ?  518  LEU A CG  1 
ATOM   3953 C  CD1 . LEU A 1 518 ? 5.76812   3.36689   38.10415  1.000 36.83161  ?  518  LEU A CD1 1 
ATOM   3954 C  CD2 . LEU A 1 518 ? 8.20988   4.06339   38.56017  1.000 31.19308  ?  518  LEU A CD2 1 
ATOM   3955 N  N   . SER A 1 519 ? 8.44021   7.93604   35.78581  1.000 34.15451  ?  519  SER A N   1 
ATOM   3956 C  CA  . SER A 1 519 ? 8.54464   8.50547   34.44624  1.000 29.59039  ?  519  SER A CA  1 
ATOM   3957 C  C   . SER A 1 519 ? 9.90091   8.14172   33.85974  1.000 33.96811  ?  519  SER A C   1 
ATOM   3958 O  O   . SER A 1 519 ? 10.82683  7.76192   34.57124  1.000 34.59264  ?  519  SER A O   1 
ATOM   3959 C  CB  . SER A 1 519 ? 8.39128   10.02768  34.45092  1.000 33.65095  ?  519  SER A CB  1 
ATOM   3960 O  OG  . SER A 1 519 ? 9.63262   10.60353  34.80231  1.000 31.51922  ?  519  SER A OG  1 
ATOM   3961 N  N   . ALA A 1 520 ? 10.02530  8.32157   32.54671  1.000 36.49483  ?  520  ALA A N   1 
ATOM   3962 C  CA  . ALA A 1 520 ? 11.28209  8.01874   31.87405  1.000 36.99703  ?  520  ALA A CA  1 
ATOM   3963 C  C   . ALA A 1 520 ? 12.42207  8.97999   32.25319  1.000 40.05271  ?  520  ALA A C   1 
ATOM   3964 O  O   . ALA A 1 520 ? 13.51324  8.85612   31.68280  1.000 37.95930  ?  520  ALA A O   1 
ATOM   3965 C  CB  . ALA A 1 520 ? 11.05779  8.01216   30.36079  1.000 35.45248  ?  520  ALA A CB  1 
ATOM   3966 N  N   . ASN A 1 521 ? 12.21555  9.93058   33.18246  1.000 35.55995  ?  521  ASN A N   1 
ATOM   3967 C  CA  . ASN A 1 521 ? 13.35578  10.58242  33.83111  1.000 35.31058  ?  521  ASN A CA  1 
ATOM   3968 C  C   . ASN A 1 521 ? 14.06854  9.67956   34.84176  1.000 38.76792  ?  521  ASN A C   1 
ATOM   3969 O  O   . ASN A 1 521 ? 15.02690  10.13525  35.47744  1.000 34.46048  ?  521  ASN A O   1 
ATOM   3970 C  CB  . ASN A 1 521 ? 12.91569  11.85660  34.54562  1.000 35.07692  ?  521  ASN A CB  1 
ATOM   3971 C  CG  . ASN A 1 521 ? 12.77923  13.03149  33.60779  1.000 39.52440  ?  521  ASN A CG  1 
ATOM   3972 O  OD1 . ASN A 1 521 ? 13.43231  13.10274  32.57152  1.000 45.95960  ?  521  ASN A OD1 1 
ATOM   3973 N  ND2 . ASN A 1 521 ? 11.89512  13.94490  33.95043  1.000 42.35028  ?  521  ASN A ND2 1 
ATOM   3974 N  N   . MET A 1 522 ? 13.61416  8.43795   35.02165  1.000 32.62057  ?  522  MET A N   1 
ATOM   3975 C  CA  . MET A 1 522 ? 14.15563  7.50733   35.99951  1.000 33.55642  ?  522  MET A CA  1 
ATOM   3976 C  C   . MET A 1 522 ? 14.69926  6.26810   35.28782  1.000 36.72883  ?  522  MET A C   1 
ATOM   3977 O  O   . MET A 1 522 ? 14.06042  5.74873   34.35981  1.000 33.67324  ?  522  MET A O   1 
ATOM   3978 C  CB  . MET A 1 522 ? 13.07159  7.10091   36.99419  1.000 31.56515  ?  522  MET A CB  1 
ATOM   3979 C  CG  . MET A 1 522 ? 12.43124  8.24638   37.76951  1.000 32.79767  ?  522  MET A CG  1 
ATOM   3980 S  SD  . MET A 1 522 ? 10.85916  7.81595   38.58466  1.000 31.08858  ?  522  MET A SD  1 
ATOM   3981 C  CE  . MET A 1 522 ? 11.21499  6.24055   39.36891  1.000 29.09126  ?  522  MET A CE  1 
ATOM   3982 N  N   . CYS A 1 523 ? 15.86474  5.77800   35.72440  1.000 29.66334  ?  523  CYS A N   1 
ATOM   3983 C  CA  . CYS A 1 523 ? 16.39946  4.60028   35.06379  1.000 36.10759  ?  523  CYS A CA  1 
ATOM   3984 C  C   . CYS A 1 523 ? 15.51966  3.39105   35.36395  1.000 29.40560  ?  523  CYS A C   1 
ATOM   3985 O  O   . CYS A 1 523 ? 14.65859  3.40922   36.24304  1.000 27.91775  ?  523  CYS A O   1 
ATOM   3986 C  CB  . CYS A 1 523 ? 17.84181  4.31430   35.48185  1.000 35.80167  ?  523  CYS A CB  1 
ATOM   3987 S  SG  . CYS A 1 523 ? 18.07580  3.87023   37.21379  1.000 34.08503  ?  523  CYS A SG  1 
ATOM   3988 N  N   . ALA A 1 524 ? 15.73989  2.33799   34.58808  1.000 31.24185  ?  524  ALA A N   1 
ATOM   3989 C  CA  . ALA A 1 524 ? 14.98116  1.10726   34.76581  1.000 27.77170  ?  524  ALA A CA  1 
ATOM   3990 C  C   . ALA A 1 524 ? 15.05629  0.60545   36.19918  1.000 31.11947  ?  524  ALA A C   1 
ATOM   3991 O  O   . ALA A 1 524 ? 14.04125  0.17906   36.76674  1.000 35.03013  ?  524  ALA A O   1 
ATOM   3992 C  CB  . ALA A 1 524 ? 15.47668  0.05600   33.77734  1.000 27.49633  ?  524  ALA A CB  1 
ATOM   3993 N  N   . THR A 1 525 ? 16.24820  0.62349   36.80630  1.000 28.31099  ?  525  THR A N   1 
ATOM   3994 C  CA  . THR A 1 525 ? 16.35948  -0.01487  38.11907  1.000 33.04764  ?  525  THR A CA  1 
ATOM   3995 C  C   . THR A 1 525 ? 15.56259  0.76737   39.15892  1.000 31.61846  ?  525  THR A C   1 
ATOM   3996 O  O   . THR A 1 525 ? 14.84982  0.18494   39.99751  1.000 28.06174  ?  525  THR A O   1 
ATOM   3997 C  CB  . THR A 1 525 ? 17.83601  -0.16435  38.53135  1.000 31.29189  ?  525  THR A CB  1 
ATOM   3998 O  OG1 . THR A 1 525 ? 18.50864  -1.03112  37.61599  1.000 35.86185  ?  525  THR A OG1 1 
ATOM   3999 C  CG2 . THR A 1 525 ? 17.96367  -0.76101  39.91265  1.000 29.03807  ?  525  THR A CG2 1 
ATOM   4000 N  N   . HIS A 1 526 ? 15.64339  2.09400   39.08069  1.000 33.76430  ?  526  HIS A N   1 
ATOM   4001 C  CA  . HIS A 1 526 ? 14.85300  2.95329   39.95338  1.000 29.67469  ?  526  HIS A CA  1 
ATOM   4002 C  C   . HIS A 1 526 ? 13.35494  2.69710   39.76564  1.000 29.64683  ?  526  HIS A C   1 
ATOM   4003 O  O   . HIS A 1 526 ? 12.59806  2.55009   40.74871  1.000 28.81718  ?  526  HIS A O   1 
ATOM   4004 C  CB  . HIS A 1 526 ? 15.23939  4.39697   39.63777  1.000 31.60888  ?  526  HIS A CB  1 
ATOM   4005 C  CG  . HIS A 1 526 ? 14.72209  5.40624   40.60132  1.000 31.22473  ?  526  HIS A CG  1 
ATOM   4006 N  ND1 . HIS A 1 526 ? 14.90938  6.75772   40.41505  1.000 32.82842  ?  526  HIS A ND1 1 
ATOM   4007 C  CD2 . HIS A 1 526 ? 14.02765  5.27438   41.75749  1.000 31.49170  ?  526  HIS A CD2 1 
ATOM   4008 C  CE1 . HIS A 1 526 ? 14.34209  7.41998   41.40994  1.000 37.78898  ?  526  HIS A CE1 1 
ATOM   4009 N  NE2 . HIS A 1 526 ? 13.81121  6.54293   42.24436  1.000 38.43627  ?  526  HIS A NE2 1 
ATOM   4010 N  N   . CYS A 1 527 ? 12.92088  2.60073   38.50106  1.000 27.68706  ?  527  CYS A N   1 
ATOM   4011 C  CA  . CYS A 1 527 ? 11.52449  2.31456   38.20641  1.000 26.21339  ?  527  CYS A CA  1 
ATOM   4012 C  C   . CYS A 1 527 ? 11.09794  0.98003   38.79121  1.000 28.06810  ?  527  CYS A C   1 
ATOM   4013 O  O   . CYS A 1 527 ? 10.01401  0.87529   39.36407  1.000 28.04164  ?  527  CYS A O   1 
ATOM   4014 C  CB  . CYS A 1 527 ? 11.28199  2.32699   36.68846  1.000 29.71305  ?  527  CYS A CB  1 
ATOM   4015 S  SG  . CYS A 1 527 ? 11.27928  3.99614   35.97450  1.000 35.01564  ?  527  CYS A SG  1 
ATOM   4016 N  N   . SER A 1 528 ? 11.92215  -0.05891  38.62952  1.000 25.43262  ?  528  SER A N   1 
ATOM   4017 C  CA  . SER A 1 528 ? 11.53189  -1.38681  39.11305  1.000 29.51745  ?  528  SER A CA  1 
ATOM   4018 C  C   . SER A 1 528 ? 11.43715  -1.41956  40.63591  1.000 31.39153  ?  528  SER A C   1 
ATOM   4019 O  O   . SER A 1 528 ? 10.59027  -2.14030  41.18708  1.000 29.21398  ?  528  SER A O   1 
ATOM   4020 C  CB  . SER A 1 528 ? 12.51900  -2.44816  38.63696  1.000 27.67611  ?  528  SER A CB  1 
ATOM   4021 O  OG  . SER A 1 528 ? 12.33388  -2.70280  37.25241  1.000 33.68619  ?  528  SER A OG  1 
ATOM   4022 N  N   . GLU A 1 529 ? 12.29547  -0.64301  41.32309  1.000 27.64988  ?  529  GLU A N   1 
ATOM   4023 C  CA  . GLU A 1 529 ? 12.22429  -0.57740  42.78056  1.000 27.02708  ?  529  GLU A CA  1 
ATOM   4024 C  C   . GLU A 1 529 ? 10.96419  0.14571   43.23945  1.000 29.01223  ?  529  GLU A C   1 
ATOM   4025 O  O   . GLU A 1 529 ? 10.31981  -0.27236  44.20702  1.000 30.35459  ?  529  GLU A O   1 
ATOM   4026 C  CB  . GLU A 1 529 ? 13.47308  0.10244   43.33509  1.000 31.83901  ?  529  GLU A CB  1 
ATOM   4027 C  CG  . GLU A 1 529 ? 14.73629  -0.76127  43.26146  1.000 31.82274  ?  529  GLU A CG  1 
ATOM   4028 C  CD  . GLU A 1 529 ? 15.99574  -0.03030  43.73694  1.000 38.63706  ?  529  GLU A CD  1 
ATOM   4029 O  OE1 . GLU A 1 529 ? 15.89365  1.17673   44.09366  1.000 35.61889  ?  529  GLU A OE1 1 
ATOM   4030 O  OE2 . GLU A 1 529 ? 17.08637  -0.66678  43.74936  1.000 35.03709  -1 529  GLU A OE2 1 
ATOM   4031 N  N   . VAL A 1 530 ? 10.59455  1.23442   42.55599  1.000 30.18895  ?  530  VAL A N   1 
ATOM   4032 C  CA  . VAL A 1 530 ? 9.33146   1.90113   42.86324  1.000 26.29719  ?  530  VAL A CA  1 
ATOM   4033 C  C   . VAL A 1 530 ? 8.14794   0.96593   42.60008  1.000 31.56917  ?  530  VAL A C   1 
ATOM   4034 O  O   . VAL A 1 530 ? 7.18112   0.92997   43.36864  1.000 30.10636  ?  530  VAL A O   1 
ATOM   4035 C  CB  . VAL A 1 530 ? 9.19938   3.20270   42.06137  1.000 28.08193  ?  530  VAL A CB  1 
ATOM   4036 C  CG1 . VAL A 1 530 ? 7.76729   3.70725   42.13742  1.000 31.08394  ?  530  VAL A CG1 1 
ATOM   4037 C  CG2 . VAL A 1 530 ? 10.17013  4.27958   42.61202  1.000 34.67161  ?  530  VAL A CG2 1 
ATOM   4038 N  N   . ILE A 1 531 ? 8.19299   0.21286   41.50089  1.000 27.29366  ?  531  ILE A N   1 
ATOM   4039 C  CA  . ILE A 1 531 ? 7.09047   -0.68905  41.19881  1.000 32.33140  ?  531  ILE A CA  1 
ATOM   4040 C  C   . ILE A 1 531 ? 6.92538   -1.72145  42.31133  1.000 30.82461  ?  531  ILE A C   1 
ATOM   4041 O  O   . ILE A 1 531 ? 5.81868   -1.91555  42.82921  1.000 30.77321  ?  531  ILE A O   1 
ATOM   4042 C  CB  . ILE A 1 531 ? 7.29173   -1.33780  39.82127  1.000 33.14417  ?  531  ILE A CB  1 
ATOM   4043 C  CG1 . ILE A 1 531 ? 7.01144   -0.28387  38.74825  1.000 30.62003  ?  531  ILE A CG1 1 
ATOM   4044 C  CG2 . ILE A 1 531 ? 6.33221   -2.52977  39.63300  1.000 28.21951  ?  531  ILE A CG2 1 
ATOM   4045 C  CD1 . ILE A 1 531 ? 7.64567   -0.57531  37.35424  1.000 27.17033  ?  531  ILE A CD1 1 
ATOM   4046 N  N   . ALA A 1 532 ? 8.03767   -2.32913  42.75670  1.000 33.76890  ?  532  ALA A N   1 
ATOM   4047 C  CA  . ALA A 1 532 ? 7.95986   -3.33508  43.82220  1.000 36.73023  ?  532  ALA A CA  1 
ATOM   4048 C  C   . ALA A 1 532 ? 7.42808   -2.73004  45.12832  1.000 32.24468  ?  532  ALA A C   1 
ATOM   4049 O  O   . ALA A 1 532 ? 6.62031   -3.34653  45.84896  1.000 37.41894  ?  532  ALA A O   1 
ATOM   4050 C  CB  . ALA A 1 532 ? 9.33719   -3.96521  44.04882  1.000 33.39062  ?  532  ALA A CB  1 
ATOM   4051 N  N   . LEU A 1 533 ? 7.85395   -1.51619  45.44486  1.000 31.67175  ?  533  LEU A N   1 
ATOM   4052 C  CA  . LEU A 1 533 ? 7.32174   -0.88692  46.64407  1.000 33.56376  ?  533  LEU A CA  1 
ATOM   4053 C  C   . LEU A 1 533 ? 5.81291   -0.67596  46.53399  1.000 31.71422  ?  533  LEU A C   1 
ATOM   4054 O  O   . LEU A 1 533 ? 5.06332   -0.97633  47.48014  1.000 27.01201  ?  533  LEU A O   1 
ATOM   4055 C  CB  . LEU A 1 533 ? 8.06309   0.41014   46.90367  1.000 28.04322  ?  533  LEU A CB  1 
ATOM   4056 C  CG  . LEU A 1 533 ? 7.57314   1.18381   48.12388  1.000 35.80576  ?  533  LEU A CG  1 
ATOM   4057 C  CD1 . LEU A 1 533 ? 7.78668   0.37421   49.38884  1.000 28.06209  ?  533  LEU A CD1 1 
ATOM   4058 C  CD2 . LEU A 1 533 ? 8.29188   2.54641   48.20381  1.000 28.43094  ?  533  LEU A CD2 1 
ATOM   4059 N  N   . VAL A 1 534 ? 5.34884   -0.22305  45.36101  1.000 31.25292  ?  534  VAL A N   1 
ATOM   4060 C  CA  . VAL A 1 534 ? 3.91519   -0.03956  45.13383  1.000 30.61534  ?  534  VAL A CA  1 
ATOM   4061 C  C   . VAL A 1 534 ? 3.16998   -1.34470  45.34053  1.000 34.47199  ?  534  VAL A C   1 
ATOM   4062 O  O   . VAL A 1 534 ? 2.05526   -1.35784  45.86492  1.000 31.76757  ?  534  VAL A O   1 
ATOM   4063 C  CB  . VAL A 1 534 ? 3.65555   0.51784   43.72174  1.000 36.28448  ?  534  VAL A CB  1 
ATOM   4064 C  CG1 . VAL A 1 534 ? 2.21949   0.24468   43.29438  1.000 34.58680  ?  534  VAL A CG1 1 
ATOM   4065 C  CG2 . VAL A 1 534 ? 3.91707   1.99392   43.68484  1.000 36.12189  ?  534  VAL A CG2 1 
ATOM   4066 N  N   . ARG A 1 535 ? 3.76367   -2.45838  44.89814  1.000 33.40042  ?  535  ARG A N   1 
ATOM   4067 C  CA  . ARG A 1 535 ? 3.14693   -3.75314  45.12031  1.000 33.07835  ?  535  ARG A CA  1 
ATOM   4068 C  C   . ARG A 1 535 ? 2.92846   -3.99449  46.60879  1.000 37.21589  ?  535  ARG A C   1 
ATOM   4069 O  O   . ARG A 1 535 ? 1.88371   -4.52545  47.02051  1.000 35.13211  ?  535  ARG A O   1 
ATOM   4070 C  CB  . ARG A 1 535 ? 4.02971   -4.86024  44.54480  1.000 37.44866  ?  535  ARG A CB  1 
ATOM   4071 C  CG  . ARG A 1 535 ? 4.05638   -4.90636  43.04797  1.000 44.39744  ?  535  ARG A CG  1 
ATOM   4072 C  CD  . ARG A 1 535 ? 4.18770   -6.33672  42.55217  1.000 40.54898  ?  535  ARG A CD  1 
ATOM   4073 N  NE  . ARG A 1 535 ? 3.56950   -6.46317  41.24055  1.000 44.78496  ?  535  ARG A NE  1 
ATOM   4074 C  CZ  . ARG A 1 535 ? 4.21514   -6.26935  40.10447  1.000 46.36218  ?  535  ARG A CZ  1 
ATOM   4075 N  NH1 . ARG A 1 535 ? 5.50917   -5.99331  40.08820  1.000 54.35927  ?  535  ARG A NH1 1 
ATOM   4076 N  NH2 . ARG A 1 535 ? 3.55028   -6.36078  38.95815  1.000 47.72923  ?  535  ARG A NH2 1 
ATOM   4077 N  N   . ARG A 1 536 ? 3.92432   -3.65130  47.42865  1.000 27.05444  ?  536  ARG A N   1 
ATOM   4078 C  CA  . ARG A 1 536 ? 3.75169   -3.88955  48.85743  1.000 28.25972  ?  536  ARG A CA  1 
ATOM   4079 C  C   . ARG A 1 536 ? 2.60804   -3.04166  49.41541  1.000 34.92610  ?  536  ARG A C   1 
ATOM   4080 O  O   . ARG A 1 536 ? 1.73571   -3.54564  50.15605  1.000 32.29332  ?  536  ARG A O   1 
ATOM   4081 C  CB  . ARG A 1 536 ? 5.06346   -3.62423  49.59244  1.000 30.00827  ?  536  ARG A CB  1 
ATOM   4082 C  CG  . ARG A 1 536 ? 6.15800   -4.63411  49.22323  1.000 35.19641  ?  536  ARG A CG  1 
ATOM   4083 C  CD  . ARG A 1 536 ? 5.73780   -6.02434  49.67354  1.000 31.25277  ?  536  ARG A CD  1 
ATOM   4084 N  NE  . ARG A 1 536 ? 5.13103   -6.79885  48.59857  1.000 42.34479  ?  536  ARG A NE  1 
ATOM   4085 C  CZ  . ARG A 1 536 ? 4.20549   -7.73267  48.78019  1.000 43.32747  ?  536  ARG A CZ  1 
ATOM   4086 N  NH1 . ARG A 1 536 ? 3.72971   -8.01785  49.98300  1.000 47.16709  ?  536  ARG A NH1 1 
ATOM   4087 N  NH2 . ARG A 1 536 ? 3.76088   -8.41290  47.73350  1.000 48.35307  ?  536  ARG A NH2 1 
ATOM   4088 N  N   . TYR A 1 537 ? 2.56612   -1.76053  49.02566  1.000 28.88160  ?  537  TYR A N   1 
ATOM   4089 C  CA  . TYR A 1 537 ? 1.47905   -0.92373  49.50570  1.000 30.28778  ?  537  TYR A CA  1 
ATOM   4090 C  C   . TYR A 1 537 ? 0.13931   -1.47910  49.07079  1.000 30.65921  ?  537  TYR A C   1 
ATOM   4091 O  O   . TYR A 1 537 ? -0.80279  -1.53571  49.86855  1.000 31.33338  ?  537  TYR A O   1 
ATOM   4092 C  CB  . TYR A 1 537 ? 1.62333   0.50029   49.00416  1.000 27.02699  ?  537  TYR A CB  1 
ATOM   4093 C  CG  . TYR A 1 537 ? 2.68428   1.29473   49.69451  1.000 29.93310  ?  537  TYR A CG  1 
ATOM   4094 C  CD1 . TYR A 1 537 ? 2.72834   1.40929   51.08672  1.000 30.31581  ?  537  TYR A CD1 1 
ATOM   4095 C  CD2 . TYR A 1 537 ? 3.65367   1.94220   48.94734  1.000 31.11916  ?  537  TYR A CD2 1 
ATOM   4096 C  CE1 . TYR A 1 537 ? 3.72250   2.16025   51.70530  1.000 31.08606  ?  537  TYR A CE1 1 
ATOM   4097 C  CE2 . TYR A 1 537 ? 4.62265   2.69819   49.54633  1.000 33.48724  ?  537  TYR A CE2 1 
ATOM   4098 C  CZ  . TYR A 1 537 ? 4.66275   2.80448   50.91086  1.000 31.98522  ?  537  TYR A CZ  1 
ATOM   4099 O  OH  . TYR A 1 537 ? 5.66864   3.57327   51.43389  1.000 32.79503  ?  537  TYR A OH  1 
ATOM   4100 N  N   . LEU A 1 538 ? 0.03971   -1.90789  47.81371  1.000 29.78609  ?  538  LEU A N   1 
ATOM   4101 C  CA  . LEU A 1 538 ? -1.22526  -2.41145  47.30434  1.000 33.91534  ?  538  LEU A CA  1 
ATOM   4102 C  C   . LEU A 1 538 ? -1.69497  -3.63417  48.08369  1.000 33.31156  ?  538  LEU A C   1 
ATOM   4103 O  O   . LEU A 1 538 ? -2.89497  -3.77709  48.34424  1.000 31.16292  ?  538  LEU A O   1 
ATOM   4104 C  CB  . LEU A 1 538 ? -1.10272  -2.74764  45.81840  1.000 33.19806  ?  538  LEU A CB  1 
ATOM   4105 C  CG  . LEU A 1 538 ? -1.17187  -1.61611  44.80600  1.000 31.69510  ?  538  LEU A CG  1 
ATOM   4106 C  CD1 . LEU A 1 538 ? -0.83119  -2.17839  43.43421  1.000 32.52205  ?  538  LEU A CD1 1 
ATOM   4107 C  CD2 . LEU A 1 538 ? -2.55081  -1.04048  44.83486  1.000 30.75371  ?  538  LEU A CD2 1 
ATOM   4108 N  N   . ALA A 1 539 ? -0.77648  -4.56556  48.39293  1.000 31.76750  ?  539  ALA A N   1 
ATOM   4109 C  CA  . ALA A 1 539 ? -1.16621  -5.75328  49.15408  1.000 33.74456  ?  539  ALA A CA  1 
ATOM   4110 C  C   . ALA A 1 539 ? -1.74909  -5.34993  50.50846  1.000 30.77956  ?  539  ALA A C   1 
ATOM   4111 O  O   . ALA A 1 539 ? -2.77917  -5.89458  50.96079  1.000 30.96872  ?  539  ALA A O   1 
ATOM   4112 C  CB  . ALA A 1 539 ? 0.04104   -6.68549  49.32812  1.000 28.05057  ?  539  ALA A CB  1 
ATOM   4113 N  N   . LEU A 1 540 ? -1.12626  -4.34993  51.14632  1.000 33.14393  ?  540  LEU A N   1 
ATOM   4114 C  CA  . LEU A 1 540 ? -1.72844  -3.79572  52.35844  1.000 34.78575  ?  540  LEU A CA  1 
ATOM   4115 C  C   . LEU A 1 540 ? -3.10983  -3.20632  52.06825  1.000 33.81380  ?  540  LEU A C   1 
ATOM   4116 O  O   . LEU A 1 540 ? -4.05886  -3.39381  52.84123  1.000 32.18716  ?  540  LEU A O   1 
ATOM   4117 C  CB  . LEU A 1 540 ? -0.80140  -2.74297  52.97652  1.000 30.54581  ?  540  LEU A CB  1 
ATOM   4118 C  CG  . LEU A 1 540 ? 0.44774   -3.34201  53.61442  1.000 32.60680  ?  540  LEU A CG  1 
ATOM   4119 C  CD1 . LEU A 1 540 ? 1.29067   -2.32462  54.38581  1.000 24.22382  ?  540  LEU A CD1 1 
ATOM   4120 C  CD2 . LEU A 1 540 ? 0.07207   -4.51263  54.51455  1.000 32.85175  ?  540  LEU A CD2 1 
ATOM   4121 N  N   . TYR A 1 541 ? -3.23845  -2.48559  50.95571  1.000 34.88922  ?  541  TYR A N   1 
ATOM   4122 C  CA  . TYR A 1 541 ? -4.48690  -1.80146  50.65910  1.000 29.58765  ?  541  TYR A CA  1 
ATOM   4123 C  C   . TYR A 1 541 ? -5.62291  -2.79347  50.49323  1.000 32.49325  ?  541  TYR A C   1 
ATOM   4124 O  O   . TYR A 1 541 ? -6.75061  -2.54527  50.94017  1.000 32.87236  ?  541  TYR A O   1 
ATOM   4125 C  CB  . TYR A 1 541 ? -4.34484  -0.95999  49.38678  1.000 34.61665  ?  541  TYR A CB  1 
ATOM   4126 C  CG  . TYR A 1 541 ? -5.64552  -0.26657  49.02025  1.000 34.60067  ?  541  TYR A CG  1 
ATOM   4127 C  CD1 . TYR A 1 541 ? -6.02645  0.87839   49.68211  1.000 26.92778  ?  541  TYR A CD1 1 
ATOM   4128 C  CD2 . TYR A 1 541 ? -6.50077  -0.77894  48.03552  1.000 29.22469  ?  541  TYR A CD2 1 
ATOM   4129 C  CE1 . TYR A 1 541 ? -7.18680  1.52833   49.36536  1.000 30.15513  ?  541  TYR A CE1 1 
ATOM   4130 C  CE2 . TYR A 1 541 ? -7.66902  -0.14187  47.72515  1.000 32.42815  ?  541  TYR A CE2 1 
ATOM   4131 C  CZ  . TYR A 1 541 ? -8.00620  1.02242   48.39737  1.000 30.83453  ?  541  TYR A CZ  1 
ATOM   4132 O  OH  . TYR A 1 541 ? -9.17697  1.70206   48.12675  1.000 36.32211  ?  541  TYR A OH  1 
ATOM   4133 N  N   . ARG A 1 542 ? -5.34000  -3.89912  49.80911  1.000 31.88607  ?  542  ARG A N   1 
ATOM   4134 C  CA  . ARG A 1 542 ? -6.32683  -4.93084  49.52706  1.000 35.40245  ?  542  ARG A CA  1 
ATOM   4135 C  C   . ARG A 1 542 ? -6.65748  -5.73937  50.76205  1.000 35.73592  ?  542  ARG A C   1 
ATOM   4136 O  O   . ARG A 1 542 ? -7.66039  -6.45848  50.74631  1.000 34.39103  ?  542  ARG A O   1 
ATOM   4137 C  CB  . ARG A 1 542 ? -5.83583  -5.89147  48.44205  1.000 38.49949  ?  542  ARG A CB  1 
ATOM   4138 C  CG  . ARG A 1 542 ? -6.15461  -5.48526  47.02065  1.000 40.81279  ?  542  ARG A CG  1 
ATOM   4139 C  CD  . ARG A 1 542 ? -5.58437  -6.50813  46.04209  1.000 37.25003  ?  542  ARG A CD  1 
ATOM   4140 N  NE  . ARG A 1 542 ? -4.92010  -5.84942  44.92452  1.000 43.44718  ?  542  ARG A NE  1 
ATOM   4141 C  CZ  . ARG A 1 542 ? -3.61198  -5.86316  44.71427  1.000 40.55965  ?  542  ARG A CZ  1 
ATOM   4142 N  NH1 . ARG A 1 542 ? -2.79872  -6.59138  45.46875  1.000 40.46777  ?  542  ARG A NH1 1 
ATOM   4143 N  NH2 . ARG A 1 542 ? -3.10303  -5.11367  43.73373  1.000 39.23056  ?  542  ARG A NH2 1 
ATOM   4144 N  N   . ALA A 1 543 ? -5.84058  -5.66091  51.82211  1.000 29.94359  ?  543  ALA A N   1 
ATOM   4145 C  CA  . ALA A 1 543 ? -6.29877  -6.23022  53.08618  1.000 34.13301  ?  543  ALA A CA  1 
ATOM   4146 C  C   . ALA A 1 543 ? -6.95395  -5.19349  54.02153  1.000 35.72706  ?  543  ALA A C   1 
ATOM   4147 O  O   . ALA A 1 543 ? -7.15000  -5.48548  55.20538  1.000 32.50992  ?  543  ALA A O   1 
ATOM   4148 C  CB  . ALA A 1 543 ? -5.15745  -6.94707  53.80938  1.000 26.09687  ?  543  ALA A CB  1 
ATOM   4149 N  N   . GLY A 1 544 ? -7.33055  -4.01984  53.51850  1.000 33.02015  ?  544  GLY A N   1 
ATOM   4150 C  CA  . GLY A 1 544 ? -7.95552  -3.01884  54.38956  1.000 31.77901  ?  544  GLY A CA  1 
ATOM   4151 C  C   . GLY A 1 544 ? -7.04235  -2.49172  55.48110  1.000 32.73290  ?  544  GLY A C   1 
ATOM   4152 O  O   . GLY A 1 544 ? -7.49511  -2.21739  56.59767  1.000 34.84859  ?  544  GLY A O   1 
ATOM   4153 N  N   . SER A 1 545 ? -5.76995  -2.31164  55.17224  1.000 29.81110  ?  545  SER A N   1 
ATOM   4154 C  CA  . SER A 1 545 ? -4.76548  -2.19495  56.21844  1.000 31.23913  ?  545  SER A CA  1 
ATOM   4155 C  C   . SER A 1 545 ? -3.71717  -1.13010  55.90376  1.000 36.36880  ?  545  SER A C   1 
ATOM   4156 O  O   . SER A 1 545 ? -2.64295  -1.14846  56.51454  1.000 34.86378  ?  545  SER A O   1 
ATOM   4157 C  CB  . SER A 1 545 ? -4.09337  -3.55232  56.41306  1.000 32.87170  ?  545  SER A CB  1 
ATOM   4158 O  OG  . SER A 1 545 ? -3.30776  -3.59122  57.57594  1.000 37.45085  ?  545  SER A OG  1 
ATOM   4159 N  N   . LEU A 1 546 ? -3.98790  -0.21632  54.95745  1.000 29.00209  ?  546  LEU A N   1 
ATOM   4160 C  CA  . LEU A 1 546 ? -3.09064  0.88807   54.63688  1.000 28.35333  ?  546  LEU A CA  1 
ATOM   4161 C  C   . LEU A 1 546 ? -3.71624  2.16133   55.17960  1.000 29.16177  ?  546  LEU A C   1 
ATOM   4162 O  O   . LEU A 1 546 ? -4.85728  2.49527   54.85241  1.000 29.08492  ?  546  LEU A O   1 
ATOM   4163 C  CB  . LEU A 1 546 ? -2.84651  0.99155   53.12884  1.000 34.21690  ?  546  LEU A CB  1 
ATOM   4164 C  CG  . LEU A 1 546 ? -1.84913  2.03485   52.59361  1.000 26.29567  ?  546  LEU A CG  1 
ATOM   4165 C  CD1 . LEU A 1 546 ? -0.45992  1.56360   52.89487  1.000 25.16427  ?  546  LEU A CD1 1 
ATOM   4166 C  CD2 . LEU A 1 546 ? -2.02702  2.22498   51.07600  1.000 27.59226  ?  546  LEU A CD2 1 
ATOM   4167 N  N   . HIS A 1 547 ? -2.99360  2.84715   56.03347  1.000 31.30236  ?  547  HIS A N   1 
ATOM   4168 C  CA  . HIS A 1 547 ? -3.60023  3.88098   56.85606  1.000 28.16432  ?  547  HIS A CA  1 
ATOM   4169 C  C   . HIS A 1 547 ? -3.55481  5.25640   56.20274  1.000 28.63634  ?  547  HIS A C   1 
ATOM   4170 O  O   . HIS A 1 547 ? -4.05491  6.21986   56.78625  1.000 29.30414  ?  547  HIS A O   1 
ATOM   4171 C  CB  . HIS A 1 547 ? -2.90693  3.89388   58.22553  1.000 26.93891  ?  547  HIS A CB  1 
ATOM   4172 C  CG  . HIS A 1 547 ? -3.22364  2.68793   59.04815  1.000 31.66893  ?  547  HIS A CG  1 
ATOM   4173 N  ND1 . HIS A 1 547 ? -2.92417  1.40265   58.63906  1.000 33.57510  ?  547  HIS A ND1 1 
ATOM   4174 C  CD2 . HIS A 1 547 ? -3.87359  2.56378   60.22693  1.000 35.93815  ?  547  HIS A CD2 1 
ATOM   4175 C  CE1 . HIS A 1 547 ? -3.34616  0.54382   59.55220  1.000 35.12588  ?  547  HIS A CE1 1 
ATOM   4176 N  NE2 . HIS A 1 547 ? -3.92495  1.22326   60.52471  1.000 33.75723  ?  547  HIS A NE2 1 
ATOM   4177 N  N   . LYS A 1 548 ? -2.97116  5.36557   55.01362  1.000 28.23476  ?  548  LYS A N   1 
ATOM   4178 C  CA  . LYS A 1 548 ? -2.96711  6.58530   54.22761  1.000 30.61478  ?  548  LYS A CA  1 
ATOM   4179 C  C   . LYS A 1 548 ? -3.48474  6.27596   52.83391  1.000 32.43966  ?  548  LYS A C   1 
ATOM   4180 O  O   . LYS A 1 548 ? -3.35688  5.14214   52.35406  1.000 30.96343  ?  548  LYS A O   1 
ATOM   4181 C  CB  . LYS A 1 548 ? -1.56006  7.19742   54.12990  1.000 31.14920  ?  548  LYS A CB  1 
ATOM   4182 C  CG  . LYS A 1 548 ? -1.13939  7.94935   55.41009  1.000 34.11766  ?  548  LYS A CG  1 
ATOM   4183 C  CD  . LYS A 1 548 ? 0.31948   8.38978   55.37700  1.000 40.34374  ?  548  LYS A CD  1 
ATOM   4184 C  CE  . LYS A 1 548 ? 0.68239   9.16281   56.66443  1.000 43.31074  ?  548  LYS A CE  1 
ATOM   4185 N  NZ  . LYS A 1 548 ? 2.07996   9.67785   56.60691  1.000 47.98535  ?  548  LYS A NZ  1 
ATOM   4186 N  N   . PRO A 1 549 ? -4.08813  7.25812   52.17515  1.000 28.02677  ?  549  PRO A N   1 
ATOM   4187 C  CA  . PRO A 1 549 ? -4.41471  7.10433   50.76289  1.000 30.66449  ?  549  PRO A CA  1 
ATOM   4188 C  C   . PRO A 1 549 ? -3.15905  6.95184   49.93298  1.000 33.09263  ?  549  PRO A C   1 
ATOM   4189 O  O   . PRO A 1 549 ? -2.09759  7.50040   50.24846  1.000 31.93269  ?  549  PRO A O   1 
ATOM   4190 C  CB  . PRO A 1 549 ? -5.14354  8.40818   50.42315  1.000 31.96697  ?  549  PRO A CB  1 
ATOM   4191 C  CG  . PRO A 1 549 ? -4.61291  9.37725   51.42517  1.000 33.25012  ?  549  PRO A CG  1 
ATOM   4192 C  CD  . PRO A 1 549 ? -4.50037  8.57768   52.67991  1.000 33.66384  ?  549  PRO A CD  1 
ATOM   4193 N  N   . LEU A 1 550 ? -3.30413  6.21112   48.84352  1.000 32.64530  ?  550  LEU A N   1 
ATOM   4194 C  CA  . LEU A 1 550 ? -2.18847  5.79616   48.01099  1.000 31.70722  ?  550  LEU A CA  1 
ATOM   4195 C  C   . LEU A 1 550 ? -2.36383  6.34756   46.60502  1.000 29.55039  ?  550  LEU A C   1 
ATOM   4196 O  O   . LEU A 1 550 ? -3.28799  5.94381   45.89683  1.000 26.58997  ?  550  LEU A O   1 
ATOM   4197 C  CB  . LEU A 1 550 ? -2.12455  4.27990   47.95753  1.000 32.83984  ?  550  LEU A CB  1 
ATOM   4198 C  CG  . LEU A 1 550 ? -1.08456  3.75124   46.98988  1.000 33.66118  ?  550  LEU A CG  1 
ATOM   4199 C  CD1 . LEU A 1 550 ? 0.29126   4.16802   47.47168  1.000 29.32401  ?  550  LEU A CD1 1 
ATOM   4200 C  CD2 . LEU A 1 550 ? -1.22926  2.22771   46.85140  1.000 28.56279  ?  550  LEU A CD2 1 
ATOM   4201 N  N   . TRP A 1 551 ? -1.45040  7.21111   46.18159  1.000 25.28396  ?  551  TRP A N   1 
ATOM   4202 C  CA  . TRP A 1 551 ? -1.51088  7.81330   44.85547  1.000 29.94848  ?  551  TRP A CA  1 
ATOM   4203 C  C   . TRP A 1 551 ? -0.20675  7.52614   44.12470  1.000 31.21017  ?  551  TRP A C   1 
ATOM   4204 O  O   . TRP A 1 551 ? 0.86916   7.87710   44.61430  1.000 34.21137  ?  551  TRP A O   1 
ATOM   4205 C  CB  . TRP A 1 551 ? -1.76053  9.31778   44.95983  1.000 24.77656  ?  551  TRP A CB  1 
ATOM   4206 C  CG  . TRP A 1 551 ? -2.95562  9.65582   45.81967  1.000 30.18030  ?  551  TRP A CG  1 
ATOM   4207 C  CD1 . TRP A 1 551 ? -4.20719  9.10759   45.73951  1.000 30.40683  ?  551  TRP A CD1 1 
ATOM   4208 C  CD2 . TRP A 1 551 ? -3.01023  10.62117  46.87726  1.000 31.36541  ?  551  TRP A CD2 1 
ATOM   4209 N  NE1 . TRP A 1 551 ? -5.02693  9.67080   46.67889  1.000 30.22421  ?  551  TRP A NE1 1 
ATOM   4210 C  CE2 . TRP A 1 551 ? -4.31700  10.58881  47.40302  1.000 29.92683  ?  551  TRP A CE2 1 
ATOM   4211 C  CE3 . TRP A 1 551 ? -2.07075  11.48341  47.45631  1.000 30.29953  ?  551  TRP A CE3 1 
ATOM   4212 C  CZ2 . TRP A 1 551 ? -4.71618  11.39986  48.46909  1.000 32.95411  ?  551  TRP A CZ2 1 
ATOM   4213 C  CZ3 . TRP A 1 551 ? -2.47481  12.28792  48.51184  1.000 34.06827  ?  551  TRP A CZ3 1 
ATOM   4214 C  CH2 . TRP A 1 551 ? -3.78854  12.25308  48.99145  1.000 30.65649  ?  551  TRP A CH2 1 
ATOM   4215 N  N   . LEU A 1 552 ? -0.29661  6.89490   42.95840  1.000 27.72225  ?  552  LEU A N   1 
ATOM   4216 C  CA  . LEU A 1 552 ? 0.86563   6.69932   42.10115  1.000 30.86826  ?  552  LEU A CA  1 
ATOM   4217 C  C   . LEU A 1 552 ? 0.69466   7.54781   40.85063  1.000 30.18923  ?  552  LEU A C   1 
ATOM   4218 O  O   . LEU A 1 552 ? -0.22744  7.30771   40.06512  1.000 28.23273  ?  552  LEU A O   1 
ATOM   4219 C  CB  . LEU A 1 552 ? 1.03309   5.23253   41.70534  1.000 27.38677  ?  552  LEU A CB  1 
ATOM   4220 C  CG  . LEU A 1 552 ? 2.06381   4.95672   40.59736  1.000 30.25044  ?  552  LEU A CG  1 
ATOM   4221 C  CD1 . LEU A 1 552 ? 3.41255   5.58604   40.90957  1.000 25.42409  ?  552  LEU A CD1 1 
ATOM   4222 C  CD2 . LEU A 1 552 ? 2.24673   3.44032   40.31141  1.000 26.56829  ?  552  LEU A CD2 1 
ATOM   4223 N  N   . VAL A 1 553 ? 1.62083   8.47808   40.62586  1.000 28.68108  ?  553  VAL A N   1 
ATOM   4224 C  CA  . VAL A 1 553 ? 1.65841   9.25075   39.38739  1.000 31.74949  ?  553  VAL A CA  1 
ATOM   4225 C  C   . VAL A 1 553 ? 2.65811   8.61208   38.43599  1.000 28.12943  ?  553  VAL A C   1 
ATOM   4226 O  O   . VAL A 1 553 ? 3.84497   8.51907   38.75095  1.000 31.57514  ?  553  VAL A O   1 
ATOM   4227 C  CB  . VAL A 1 553 ? 2.02775   10.71482  39.65066  1.000 30.07476  ?  553  VAL A CB  1 
ATOM   4228 C  CG1 . VAL A 1 553 ? 2.01201   11.46969  38.34070  1.000 32.51977  ?  553  VAL A CG1 1 
ATOM   4229 C  CG2 . VAL A 1 553 ? 1.03838   11.31814  40.63331  1.000 27.99599  ?  553  VAL A CG2 1 
ATOM   4230 N  N   . SER A 1 554 ? 2.19647   8.22296   37.24890  1.000 27.99553  ?  554  SER A N   1 
ATOM   4231 C  CA  . SER A 1 554 ? 3.04271   7.56235   36.26695  1.000 27.49394  ?  554  SER A CA  1 
ATOM   4232 C  C   . SER A 1 554 ? 2.77421   8.13765   34.88425  1.000 30.13774  ?  554  SER A C   1 
ATOM   4233 O  O   . SER A 1 554 ? 1.79216   8.85195   34.65611  1.000 32.92538  ?  554  SER A O   1 
ATOM   4234 C  CB  . SER A 1 554 ? 2.81291   6.03172   36.24834  1.000 29.64620  ?  554  SER A CB  1 
ATOM   4235 O  OG  . SER A 1 554 ? 3.70830   5.40253   35.33971  1.000 30.16210  ?  554  SER A OG  1 
ATOM   4236 N  N   . THR A 1 555 ? 3.69704   7.86437   33.97017  1.000 29.46392  ?  555  THR A N   1 
ATOM   4237 C  CA  . THR A 1 555 ? 3.52076   8.13776   32.55609  1.000 33.08220  ?  555  THR A CA  1 
ATOM   4238 C  C   . THR A 1 555 ? 3.03659   6.87300   31.88656  1.000 33.78595  ?  555  THR A C   1 
ATOM   4239 O  O   . THR A 1 555 ? 2.76346   5.86323   32.55122  1.000 34.78162  ?  555  THR A O   1 
ATOM   4240 C  CB  . THR A 1 555 ? 4.81092   8.62434   31.89465  1.000 32.49125  ?  555  THR A CB  1 
ATOM   4241 O  OG1 . THR A 1 555 ? 5.85537   7.64762   32.07142  1.000 32.24981  ?  555  THR A OG1 1 
ATOM   4242 C  CG2 . THR A 1 555 ? 5.22464   9.94880   32.47778  1.000 32.96025  ?  555  THR A CG2 1 
ATOM   4243 N  N   . GLN A 1 556 ? 2.97104   6.90033   30.55261  1.000 35.62573  ?  556  GLN A N   1 
ATOM   4244 C  CA  . GLN A 1 556 ? 2.46276   5.73196   29.85122  1.000 33.19249  ?  556  GLN A CA  1 
ATOM   4245 C  C   . GLN A 1 556 ? 3.38358   4.53800   29.97945  1.000 35.28726  ?  556  GLN A C   1 
ATOM   4246 O  O   . GLN A 1 556 ? 2.96192   3.41880   29.65115  1.000 38.76745  ?  556  GLN A O   1 
ATOM   4247 C  CB  . GLN A 1 556 ? 2.20087   6.02739   28.36976  1.000 40.52207  ?  556  GLN A CB  1 
ATOM   4248 C  CG  . GLN A 1 556 ? 3.37146   6.52716   27.57667  1.000 42.60131  ?  556  GLN A CG  1 
ATOM   4249 C  CD  . GLN A 1 556 ? 3.63436   8.00271   27.82147  1.000 43.97478  ?  556  GLN A CD  1 
ATOM   4250 O  OE1 . GLN A 1 556 ? 4.67189   8.36434   28.36874  1.000 39.88826  ?  556  GLN A OE1 1 
ATOM   4251 N  NE2 . GLN A 1 556 ? 2.69400   8.86630   27.40756  1.000 47.91339  ?  556  GLN A NE2 1 
ATOM   4252 N  N   . LEU A 1 557 ? 4.60313   4.71009   30.49336  1.000 35.81078  ?  557  LEU A N   1 
ATOM   4253 C  CA  . LEU A 1 557 ? 5.47136   3.53536   30.59954  1.000 38.43761  ?  557  LEU A CA  1 
ATOM   4254 C  C   . LEU A 1 557 ? 4.84369   2.43515   31.46014  1.000 39.88661  ?  557  LEU A C   1 
ATOM   4255 O  O   . LEU A 1 557 ? 5.25529   1.27357   31.36536  1.000 44.77364  ?  557  LEU A O   1 
ATOM   4256 C  CB  . LEU A 1 557 ? 6.86119   3.91687   31.13820  1.000 38.24820  ?  557  LEU A CB  1 
ATOM   4257 C  CG  . LEU A 1 557 ? 7.10003   4.64768   32.46579  1.000 38.62007  ?  557  LEU A CG  1 
ATOM   4258 C  CD1 . LEU A 1 557 ? 6.80197   3.75333   33.64648  1.000 46.57633  ?  557  LEU A CD1 1 
ATOM   4259 C  CD2 . LEU A 1 557 ? 8.54463   5.11335   32.58938  1.000 34.60149  ?  557  LEU A CD2 1 
ATOM   4260 N  N   . ILE A 1 558 ? 3.86972   2.77662   32.30663  1.000 40.00504  ?  558  ILE A N   1 
ATOM   4261 C  CA  . ILE A 1 558 ? 3.19140   1.77912   33.13031  1.000 42.20637  ?  558  ILE A CA  1 
ATOM   4262 C  C   . ILE A 1 558 ? 2.18942   0.94072   32.31599  1.000 43.19448  ?  558  ILE A C   1 
ATOM   4263 O  O   . ILE A 1 558 ? 1.86186   -0.18111  32.71978  1.000 39.22702  ?  558  ILE A O   1 
ATOM   4264 C  CB  . ILE A 1 558 ? 2.50378   2.46107   34.33381  1.000 39.12162  ?  558  ILE A CB  1 
ATOM   4265 C  CG1 . ILE A 1 558 ? 2.21428   1.47210   35.46258  1.000 43.61224  ?  558  ILE A CG1 1 
ATOM   4266 C  CG2 . ILE A 1 558 ? 1.17443   3.08610   33.92859  1.000 36.40465  ?  558  ILE A CG2 1 
ATOM   4267 C  CD1 . ILE A 1 558 ? 3.19882   1.50184   36.55320  1.000 47.02983  ?  558  ILE A CD1 1 
ATOM   4268 N  N   . GLU A 1 559 ? 1.65134   1.46412   31.19892  1.000 43.29129  ?  559  GLU A N   1 
ATOM   4269 C  CA  . GLU A 1 559 ? 0.61220   0.73157   30.46470  1.000 44.10081  ?  559  GLU A CA  1 
ATOM   4270 C  C   . GLU A 1 559 ? 1.20298   -0.34437  29.58339  1.000 43.76818  ?  559  GLU A C   1 
ATOM   4271 O  O   . GLU A 1 559 ? 0.45746   -1.16867  29.03812  1.000 44.34431  ?  559  GLU A O   1 
ATOM   4272 C  CB  . GLU A 1 559 ? -0.24944  1.65484   29.57265  1.000 38.05019  ?  559  GLU A CB  1 
ATOM   4273 C  CG  . GLU A 1 559 ? -0.39030  3.07530   30.07271  1.000 42.26562  ?  559  GLU A CG  1 
ATOM   4274 C  CD  . GLU A 1 559 ? -1.15030  3.97105   29.12325  1.000 34.83154  ?  559  GLU A CD  1 
ATOM   4275 O  OE1 . GLU A 1 559 ? -0.66277  4.25155   28.00869  1.000 35.67899  ?  559  GLU A OE1 1 
ATOM   4276 O  OE2 . GLU A 1 559 ? -2.24505  4.44429   29.52834  1.000 43.68749  -1 559  GLU A OE2 1 
ATOM   4277 N  N   . ALA A 1 560 ? 2.52041   -0.34241  29.43205  1.000 45.06839  ?  560  ALA A N   1 
ATOM   4278 C  CA  . ALA A 1 560 ? 3.20555   -1.28172  28.56559  1.000 48.90725  ?  560  ALA A CA  1 
ATOM   4279 C  C   . ALA A 1 560 ? 3.87217   -2.35522  29.42100  1.000 47.75782  ?  560  ALA A C   1 
ATOM   4280 O  O   . ALA A 1 560 ? 5.06451   -2.30443  29.72521  1.000 51.46015  ?  560  ALA A O   1 
ATOM   4281 C  CB  . ALA A 1 560 ? 4.20178   -0.53769  27.70613  1.000 51.91056  ?  560  ALA A CB  1 
ATOM   4282 N  N   . GLY A 1 561 ? 3.07118   -3.34074  29.82266  1.000 45.60540  ?  561  GLY A N   1 
ATOM   4283 C  CA  . GLY A 1 561 ? 3.58854   -4.56120  30.40226  1.000 48.41852  ?  561  GLY A CA  1 
ATOM   4284 C  C   . GLY A 1 561 ? 3.78192   -4.57685  31.90225  1.000 48.62806  ?  561  GLY A C   1 
ATOM   4285 O  O   . GLY A 1 561 ? 4.20338   -5.61676  32.43301  1.000 52.61075  ?  561  GLY A O   1 
ATOM   4286 N  N   . VAL A 1 562 ? 3.51446   -3.47027  32.60615  1.000 42.34390  ?  562  VAL A N   1 
ATOM   4287 C  CA  . VAL A 1 562 ? 3.57209   -3.48997  34.06407  1.000 42.18158  ?  562  VAL A CA  1 
ATOM   4288 C  C   . VAL A 1 562 ? 2.28249   -4.09757  34.59709  1.000 40.41479  ?  562  VAL A C   1 
ATOM   4289 O  O   . VAL A 1 562 ? 1.18051   -3.64674  34.26800  1.000 40.42775  ?  562  VAL A O   1 
ATOM   4290 C  CB  . VAL A 1 562 ? 3.79021   -2.08480  34.63871  1.000 38.52693  ?  562  VAL A CB  1 
ATOM   4291 C  CG1 . VAL A 1 562 ? 3.68107   -2.15309  36.15805  1.000 38.79623  ?  562  VAL A CG1 1 
ATOM   4292 C  CG2 . VAL A 1 562 ? 5.14835   -1.50276  34.19907  1.000 36.11173  ?  562  VAL A CG2 1 
ATOM   4293 N  N   . ASP A 1 563 ? 2.41113   -5.11716  35.42008  1.000 42.69785  ?  563  ASP A N   1 
ATOM   4294 C  CA  . ASP A 1 563 ? 1.25357   -5.81314  35.97500  1.000 47.65755  ?  563  ASP A CA  1 
ATOM   4295 C  C   . ASP A 1 563 ? 0.96602   -5.22394  37.35598  1.000 44.07229  ?  563  ASP A C   1 
ATOM   4296 O  O   . ASP A 1 563 ? 1.59059   -5.60444  38.34793  1.000 46.01669  ?  563  ASP A O   1 
ATOM   4297 C  CB  . ASP A 1 563 ? 1.51890   -7.31199  36.03486  1.000 44.94915  ?  563  ASP A CB  1 
ATOM   4298 C  CG  . ASP A 1 563 ? 0.50385   -8.05661  36.87635  1.000 54.94078  ?  563  ASP A CG  1 
ATOM   4299 O  OD1 . ASP A 1 563 ? -0.69130  -7.67644  36.85828  1.000 53.16871  -1 563  ASP A OD1 1 
ATOM   4300 O  OD2 . ASP A 1 563 ? 0.91664   -9.00537  37.59015  1.000 58.96226  -1 563  ASP A OD2 1 
ATOM   4301 N  N   . LEU A 1 564 ? 0.03535   -4.28031  37.41362  1.000 38.03106  ?  564  LEU A N   1 
ATOM   4302 C  CA  . LEU A 1 564 ? -0.43179  -3.72092  38.67135  1.000 39.70869  ?  564  LEU A CA  1 
ATOM   4303 C  C   . LEU A 1 564 ? -1.94521  -3.66251  38.64374  1.000 37.74641  ?  564  LEU A C   1 
ATOM   4304 O  O   . LEU A 1 564 ? -2.54610  -3.47331  37.58758  1.000 35.82594  ?  564  LEU A O   1 
ATOM   4305 C  CB  . LEU A 1 564 ? 0.13173   -2.32859  38.91172  1.000 38.85521  ?  564  LEU A CB  1 
ATOM   4306 C  CG  . LEU A 1 564 ? 1.61909   -2.31722  39.23399  1.000 46.20046  ?  564  LEU A CG  1 
ATOM   4307 C  CD1 . LEU A 1 564 ? 2.13099   -0.87746  39.39089  1.000 38.40516  ?  564  LEU A CD1 1 
ATOM   4308 C  CD2 . LEU A 1 564 ? 1.92803   -3.19940  40.46350  1.000 45.57746  ?  564  LEU A CD2 1 
ATOM   4309 N  N   . ASP A 1 565 ? -2.56110  -3.81644  39.81021  1.000 35.18295  ?  565  ASP A N   1 
ATOM   4310 C  CA  . ASP A 1 565 ? -4.01746  -3.82626  39.92640  1.000 34.76761  ?  565  ASP A CA  1 
ATOM   4311 C  C   . ASP A 1 565 ? -4.50466  -2.75634  40.91216  1.000 35.00161  ?  565  ASP A C   1 
ATOM   4312 O  O   . ASP A 1 565 ? -4.46808  -2.96347  42.12919  1.000 31.61773  ?  565  ASP A O   1 
ATOM   4313 C  CB  . ASP A 1 565 ? -4.48613  -5.20927  40.35543  1.000 37.17064  ?  565  ASP A CB  1 
ATOM   4314 C  CG  . ASP A 1 565 ? -5.94912  -5.43051  40.07773  1.000 40.88495  ?  565  ASP A CG  1 
ATOM   4315 O  OD1 . ASP A 1 565 ? -6.64035  -4.43163  39.82241  1.000 43.37184  ?  565  ASP A OD1 1 
ATOM   4316 O  OD2 . ASP A 1 565 ? -6.41591  -6.58767  40.11766  1.000 42.88468  -1 565  ASP A OD2 1 
ATOM   4317 N  N   . PHE A 1 566 ? -5.04431  -1.61477  40.37535  1.000 32.05087  ?  566  PHE A N   1 
ATOM   4318 C  CA  . PHE A 1 566 ? -5.63537  -0.50799  41.12375  1.000 28.55379  ?  566  PHE A CA  1 
ATOM   4319 C  C   . PHE A 1 566 ? -7.14644  -0.53027  41.02559  1.000 29.73000  ?  566  PHE A C   1 
ATOM   4320 O  O   . PHE A 1 566 ? -7.70077  -0.97994  40.02411  1.000 33.64044  ?  566  PHE A O   1 
ATOM   4321 C  CB  . PHE A 1 566 ? -5.14154  0.85288   40.60466  1.000 31.16422  ?  566  PHE A CB  1 
ATOM   4322 C  CG  . PHE A 1 566 ? -3.73185  1.17051   41.02234  1.000 36.38857  ?  566  PHE A CG  1 
ATOM   4323 C  CD1 . PHE A 1 566 ? -2.66012  0.57171   40.38308  1.000 29.98112  ?  566  PHE A CD1 1 
ATOM   4324 C  CD2 . PHE A 1 566 ? -3.48394  2.03523   42.09587  1.000 32.51685  ?  566  PHE A CD2 1 
ATOM   4325 C  CE1 . PHE A 1 566 ? -1.36744  0.82518   40.77569  1.000 28.90356  ?  566  PHE A CE1 1 
ATOM   4326 C  CE2 . PHE A 1 566 ? -2.17707  2.31286   42.48689  1.000 31.54317  ?  566  PHE A CE2 1 
ATOM   4327 C  CZ  . PHE A 1 566 ? -1.12047  1.70625   41.82180  1.000 33.43930  ?  566  PHE A CZ  1 
ATOM   4328 N  N   . PRO A 1 567 ? -7.83527  -0.06740  42.07157  1.000 25.17752  ?  567  PRO A N   1 
ATOM   4329 C  CA  . PRO A 1 567 ? -9.29879  0.05298   41.99181  1.000 24.89083  ?  567  PRO A CA  1 
ATOM   4330 C  C   . PRO A 1 567 ? -9.76728  1.25208   41.20145  1.000 30.37008  ?  567  PRO A C   1 
ATOM   4331 O  O   . PRO A 1 567 ? -10.91520 1.25394   40.72609  1.000 30.88495  ?  567  PRO A O   1 
ATOM   4332 C  CB  . PRO A 1 567 ? -9.72553  0.17144   43.46631  1.000 26.75574  ?  567  PRO A CB  1 
ATOM   4333 C  CG  . PRO A 1 567 ? -8.49411  0.68068   44.17597  1.000 27.76508  ?  567  PRO A CG  1 
ATOM   4334 C  CD  . PRO A 1 567 ? -7.32460  0.08077   43.44553  1.000 26.05406  ?  567  PRO A CD  1 
ATOM   4335 N  N   . CYS A 1 568 ? -8.93414  2.28444   41.07568  1.000 27.54997  ?  568  CYS A N   1 
ATOM   4336 C  CA  . CYS A 1 568 ? -9.29908  3.45837   40.30617  1.000 32.45958  ?  568  CYS A CA  1 
ATOM   4337 C  C   . CYS A 1 568 ? -8.09882  3.84487   39.45615  1.000 31.22523  ?  568  CYS A C   1 
ATOM   4338 O  O   . CYS A 1 568 ? -6.98226  3.91089   39.96543  1.000 30.53855  ?  568  CYS A O   1 
ATOM   4339 C  CB  . CYS A 1 568 ? -9.72021  4.60423   41.24705  1.000 31.28359  ?  568  CYS A CB  1 
ATOM   4340 S  SG  . CYS A 1 568 ? -9.94949  6.21788   40.45786  1.000 36.36254  ?  568  CYS A SG  1 
ATOM   4341 N  N   . VAL A 1 569 ? -8.31093  4.09468   38.16946  1.000 33.91810  ?  569  VAL A N   1 
ATOM   4342 C  CA  . VAL A 1 569 ? -7.25236  4.62744   37.31315  1.000 32.96404  ?  569  VAL A CA  1 
ATOM   4343 C  C   . VAL A 1 569 ? -7.71300  5.93135   36.67526  1.000 31.66339  ?  569  VAL A C   1 
ATOM   4344 O  O   . VAL A 1 569 ? -8.79075  5.99201   36.06944  1.000 33.07436  ?  569  VAL A O   1 
ATOM   4345 C  CB  . VAL A 1 569 ? -6.81828  3.62071   36.23077  1.000 33.84534  ?  569  VAL A CB  1 
ATOM   4346 C  CG1 . VAL A 1 569 ? -5.94808  4.33059   35.18663  1.000 29.37294  ?  569  VAL A CG1 1 
ATOM   4347 C  CG2 . VAL A 1 569 ? -6.05050  2.44719   36.87353  1.000 28.21151  ?  569  VAL A CG2 1 
ATOM   4348 N  N   . TYR A 1 570 ? -6.88694  6.97135   36.81958  1.000 35.30066  ?  570  TYR A N   1 
ATOM   4349 C  CA  . TYR A 1 570 ? -7.03128  8.23214   36.11016  1.000 29.70291  ?  570  TYR A CA  1 
ATOM   4350 C  C   . TYR A 1 570 ? -6.10029  8.22658   34.90565  1.000 32.75725  ?  570  TYR A C   1 
ATOM   4351 O  O   . TYR A 1 570 ? -4.90941  7.92660   35.04899  1.000 30.13272  ?  570  TYR A O   1 
ATOM   4352 C  CB  . TYR A 1 570 ? -6.69399  9.40841   37.03090  1.000 29.18293  ?  570  TYR A CB  1 
ATOM   4353 C  CG  . TYR A 1 570 ? -7.92179  9.98281   37.71703  1.000 31.24006  ?  570  TYR A CG  1 
ATOM   4354 C  CD1 . TYR A 1 570 ? -8.71910  9.19370   38.54879  1.000 26.24649  ?  570  TYR A CD1 1 
ATOM   4355 C  CD2 . TYR A 1 570 ? -8.29026  11.30481  37.51289  1.000 27.00961  ?  570  TYR A CD2 1 
ATOM   4356 C  CE1 . TYR A 1 570 ? -9.83880  9.71682   39.15409  1.000 25.40183  ?  570  TYR A CE1 1 
ATOM   4357 C  CE2 . TYR A 1 570 ? -9.40315  11.82962  38.09116  1.000 27.76465  ?  570  TYR A CE2 1 
ATOM   4358 C  CZ  . TYR A 1 570 ? -10.17968 11.04969  38.90785  1.000 27.85326  ?  570  TYR A CZ  1 
ATOM   4359 O  OH  . TYR A 1 570 ? -11.28086 11.63224  39.47693  1.000 32.17187  ?  570  TYR A OH  1 
ATOM   4360 N  N   . ARG A 1 571 ? -6.64283  8.55371   33.72093  1.000 30.98453  ?  571  ARG A N   1 
ATOM   4361 C  CA  . ARG A 1 571 ? -5.88280  8.54317   32.47327  1.000 31.27252  ?  571  ARG A CA  1 
ATOM   4362 C  C   . ARG A 1 571 ? -6.04633  9.86831   31.74223  1.000 30.53918  ?  571  ARG A C   1 
ATOM   4363 O  O   . ARG A 1 571 ? -7.17064  10.29758  31.48005  1.000 31.23916  ?  571  ARG A O   1 
ATOM   4364 C  CB  . ARG A 1 571 ? -6.33203  7.40691   31.55520  1.000 22.72877  ?  571  ARG A CB  1 
ATOM   4365 C  CG  . ARG A 1 571 ? -5.56135  7.28326   30.27270  1.000 27.05349  ?  571  ARG A CG  1 
ATOM   4366 C  CD  . ARG A 1 571 ? -4.09282  7.13852   30.54503  1.000 32.45404  ?  571  ARG A CD  1 
ATOM   4367 N  NE  . ARG A 1 571 ? -3.29037  6.66060   29.42328  1.000 28.83084  ?  571  ARG A NE  1 
ATOM   4368 C  CZ  . ARG A 1 571 ? -2.51010  7.45359   28.69928  1.000 29.72247  ?  571  ARG A CZ  1 
ATOM   4369 N  NH1 . ARG A 1 571 ? -2.59110  8.77539   28.79152  1.000 31.17698  ?  571  ARG A NH1 1 
ATOM   4370 N  NH2 . ARG A 1 571 ? -1.62906  6.91446   27.86889  1.000 25.90724  ?  571  ARG A NH2 1 
ATOM   4371 N  N   . ALA A 1 572 ? -4.92379  10.49232  31.39716  1.000 30.04946  ?  572  ALA A N   1 
ATOM   4372 C  CA  . ALA A 1 572 ? -4.94599  11.66833  30.54574  1.000 32.72696  ?  572  ALA A CA  1 
ATOM   4373 C  C   . ALA A 1 572 ? -5.44730  11.29437  29.15668  1.000 34.24024  ?  572  ALA A C   1 
ATOM   4374 O  O   . ALA A 1 572 ? -5.17311  10.19938  28.64322  1.000 32.85533  ?  572  ALA A O   1 
ATOM   4375 C  CB  . ALA A 1 572 ? -3.54790  12.27395  30.42643  1.000 32.26072  ?  572  ALA A CB  1 
ATOM   4376 N  N   . MET A 1 573 ? -6.17073  12.22873  28.54649  1.000 31.34407  ?  573  MET A N   1 
ATOM   4377 C  CA  . MET A 1 573 ? -6.73870  12.02135  27.22010  1.000 35.66237  ?  573  MET A CA  1 
ATOM   4378 C  C   . MET A 1 573 ? -5.68001  11.48393  26.27149  1.000 32.84593  ?  573  MET A C   1 
ATOM   4379 O  O   . MET A 1 573 ? -4.56372  12.01273  26.19439  1.000 32.34692  ?  573  MET A O   1 
ATOM   4380 C  CB  . MET A 1 573 ? -7.32371  13.34486  26.69276  1.000 39.64720  ?  573  MET A CB  1 
ATOM   4381 C  CG  . MET A 1 573 ? -8.10793  13.20371  25.40828  1.000 40.12563  ?  573  MET A CG  1 
ATOM   4382 S  SD  . MET A 1 573 ? -9.66613  12.38450  25.76038  1.000 51.92582  ?  573  MET A SD  1 
ATOM   4383 C  CE  . MET A 1 573 ? -10.63585 12.92836  24.36432  1.000 41.45288  ?  573  MET A CE  1 
ATOM   4384 N  N   . ALA A 1 574 ? -6.00904  10.39264  25.58927  1.000 30.40256  ?  574  ALA A N   1 
ATOM   4385 C  CA  . ALA A 1 574 ? -5.04660  9.77645   24.69239  1.000 26.40043  ?  574  ALA A CA  1 
ATOM   4386 C  C   . ALA A 1 574 ? -5.79888  8.84919   23.74951  1.000 33.37461  ?  574  ALA A C   1 
ATOM   4387 O  O   . ALA A 1 574 ? -7.03201  8.75670   23.79048  1.000 33.28553  ?  574  ALA A O   1 
ATOM   4388 C  CB  . ALA A 1 574 ? -3.95654  9.04923   25.48225  1.000 27.52036  ?  574  ALA A CB  1 
ATOM   4389 N  N   . GLY A 1 575 ? -5.04416  8.16634   22.89126  1.000 29.22864  ?  575  GLY A N   1 
ATOM   4390 C  CA  . GLY A 1 575 ? -5.66229  7.26426   21.94153  1.000 28.14865  ?  575  GLY A CA  1 
ATOM   4391 C  C   . GLY A 1 575 ? -6.43207  6.16368   22.64346  1.000 33.22820  ?  575  GLY A C   1 
ATOM   4392 O  O   . GLY A 1 575 ? -6.09006  5.73222   23.75124  1.000 26.39963  ?  575  GLY A O   1 
ATOM   4393 N  N   . LEU A 1 576 ? -7.50455  5.71890   21.98561  1.000 33.66630  ?  576  LEU A N   1 
ATOM   4394 C  CA  . LEU A 1 576 ? -8.38731  4.74098   22.59774  1.000 29.94406  ?  576  LEU A CA  1 
ATOM   4395 C  C   . LEU A 1 576 ? -7.62817  3.48905   23.02062  1.000 28.13849  ?  576  LEU A C   1 
ATOM   4396 O  O   . LEU A 1 576 ? -7.94172  2.90336   24.06162  1.000 31.65277  ?  576  LEU A O   1 
ATOM   4397 C  CB  . LEU A 1 576 ? -9.52094  4.42102   21.62291  1.000 32.50803  ?  576  LEU A CB  1 
ATOM   4398 C  CG  . LEU A 1 576 ? -10.85207 3.93922   22.17095  1.000 35.99547  ?  576  LEU A CG  1 
ATOM   4399 C  CD1 . LEU A 1 576 ? -11.21775 4.70843   23.43883  1.000 37.05681  ?  576  LEU A CD1 1 
ATOM   4400 C  CD2 . LEU A 1 576 ? -11.92375 4.08095   21.09288  1.000 40.03535  ?  576  LEU A CD2 1 
ATOM   4401 N  N   . ASP A 1 577 ? -6.59570  3.08393   22.26996  1.000 29.07778  ?  577  ASP A N   1 
ATOM   4402 C  CA  . ASP A 1 577 ? -5.83495  1.91021   22.70427  1.000 34.18466  ?  577  ASP A CA  1 
ATOM   4403 C  C   . ASP A 1 577 ? -5.06805  2.18689   23.99908  1.000 30.30775  ?  577  ASP A C   1 
ATOM   4404 O  O   . ASP A 1 577 ? -4.98112  1.31754   24.87365  1.000 28.54764  ?  577  ASP A O   1 
ATOM   4405 C  CB  . ASP A 1 577 ? -4.88979  1.41269   21.59725  1.000 31.27903  ?  577  ASP A CB  1 
ATOM   4406 C  CG  . ASP A 1 577 ? -3.98563  2.50707   21.03480  1.000 38.71963  ?  577  ASP A CG  1 
ATOM   4407 O  OD1 . ASP A 1 577 ? -4.24570  3.72089   21.23890  1.000 30.67478  ?  577  ASP A OD1 1 
ATOM   4408 O  OD2 . ASP A 1 577 ? -2.98819  2.13098   20.38573  1.000 40.39439  -1 577  ASP A OD2 1 
ATOM   4409 N  N   . SER A 1 578 ? -4.51606  3.38682   24.14544  1.000 27.88154  ?  578  SER A N   1 
ATOM   4410 C  CA  . SER A 1 578 ? -3.83940  3.74815   25.38996  1.000 27.87584  ?  578  SER A CA  1 
ATOM   4411 C  C   . SER A 1 578 ? -4.80021  3.73539   26.57622  1.000 30.92781  ?  578  SER A C   1 
ATOM   4412 O  O   . SER A 1 578 ? -4.43968  3.27984   27.67583  1.000 27.70753  ?  578  SER A O   1 
ATOM   4413 C  CB  . SER A 1 578 ? -3.20154  5.13533   25.26256  1.000 28.91383  ?  578  SER A CB  1 
ATOM   4414 O  OG  . SER A 1 578 ? -2.13031  5.13307   24.34289  1.000 31.29991  ?  578  SER A OG  1 
ATOM   4415 N  N   . ILE A 1 579 ? -6.01349  4.26833   26.37729  1.000 27.41181  ?  579  ILE A N   1 
ATOM   4416 C  CA  . ILE A 1 579 ? -7.04722  4.26338   27.40879  1.000 25.21751  ?  579  ILE A CA  1 
ATOM   4417 C  C   . ILE A 1 579 ? -7.39713  2.84196   27.80785  1.000 31.37500  ?  579  ILE A C   1 
ATOM   4418 O  O   . ILE A 1 579 ? -7.55097  2.53329   29.00068  1.000 27.98583  ?  579  ILE A O   1 
ATOM   4419 C  CB  . ILE A 1 579 ? -8.28886  5.02300   26.90984  1.000 27.86090  ?  579  ILE A CB  1 
ATOM   4420 C  CG1 . ILE A 1 579 ? -7.94192  6.49751   26.68624  1.000 26.84676  ?  579  ILE A CG1 1 
ATOM   4421 C  CG2 . ILE A 1 579 ? -9.47407  4.82620   27.84840  1.000 25.24181  ?  579  ILE A CG2 1 
ATOM   4422 C  CD1 . ILE A 1 579 ? -9.07481  7.30250   26.13045  1.000 32.34762  ?  579  ILE A CD1 1 
ATOM   4423 N  N   . ALA A 1 580 ? -7.51055  1.94403   26.82572  1.000 27.37240  ?  580  ALA A N   1 
ATOM   4424 C  CA  . ALA A 1 580 ? -7.75603  0.54973   27.18019  1.000 32.35751  ?  580  ALA A CA  1 
ATOM   4425 C  C   . ALA A 1 580 ? -6.57557  -0.03969  27.96499  1.000 33.59585  ?  580  ALA A C   1 
ATOM   4426 O  O   . ALA A 1 580 ? -6.76827  -0.78218  28.93779  1.000 37.35185  ?  580  ALA A O   1 
ATOM   4427 C  CB  . ALA A 1 580 ? -8.05828  -0.26220  25.91593  1.000 27.39349  ?  580  ALA A CB  1 
ATOM   4428 N  N   . GLN A 1 581 ? -5.34218  0.26211   27.55543  1.000 30.22989  ?  581  GLN A N   1 
ATOM   4429 C  CA  . GLN A 1 581 ? -4.21020  -0.28177  28.29896  1.000 33.13112  ?  581  GLN A CA  1 
ATOM   4430 C  C   . GLN A 1 581 ? -4.22081  0.22866   29.73968  1.000 33.07974  ?  581  GLN A C   1 
ATOM   4431 O  O   . GLN A 1 581 ? -3.87150  -0.50208  30.67131  1.000 33.44625  ?  581  GLN A O   1 
ATOM   4432 C  CB  . GLN A 1 581 ? -2.88870  0.06493   27.62005  1.000 33.42371  ?  581  GLN A CB  1 
ATOM   4433 C  CG  . GLN A 1 581 ? -2.59812  -0.64936  26.31059  1.000 34.82449  ?  581  GLN A CG  1 
ATOM   4434 C  CD  . GLN A 1 581 ? -1.31014  -0.12912  25.68545  1.000 45.54251  ?  581  GLN A CD  1 
ATOM   4435 O  OE1 . GLN A 1 581 ? -1.22164  1.04267   25.26325  1.000 41.57044  ?  581  GLN A OE1 1 
ATOM   4436 N  NE2 . GLN A 1 581 ? -0.28176  -0.98166  25.66643  1.000 48.42672  ?  581  GLN A NE2 1 
ATOM   4437 N  N   . ALA A 1 582 ? -4.60053  1.48930   29.93666  1.000 33.00908  ?  582  ALA A N   1 
ATOM   4438 C  CA  . ALA A 1 582 ? -4.69612  2.02678   31.28745  1.000 32.77437  ?  582  ALA A CA  1 
ATOM   4439 C  C   . ALA A 1 582 ? -5.78370  1.31391   32.08738  1.000 31.64851  ?  582  ALA A C   1 
ATOM   4440 O  O   . ALA A 1 582 ? -5.59094  0.97971   33.25720  1.000 30.85419  ?  582  ALA A O   1 
ATOM   4441 C  CB  . ALA A 1 582 ? -4.95316  3.53096   31.23153  1.000 30.02183  ?  582  ALA A CB  1 
ATOM   4442 N  N   . ALA A 1 583 ? -6.94639  1.09039   31.47984  1.000 31.57332  ?  583  ALA A N   1 
ATOM   4443 C  CA  . ALA A 1 583 ? -7.99950  0.37549   32.18225  1.000 33.06539  ?  583  ALA A CA  1 
ATOM   4444 C  C   . ALA A 1 583 ? -7.57687  -1.04837  32.53541  1.000 34.25969  ?  583  ALA A C   1 
ATOM   4445 O  O   . ALA A 1 583 ? -8.11640  -1.63234  33.48272  1.000 30.76299  ?  583  ALA A O   1 
ATOM   4446 C  CB  . ALA A 1 583 ? -9.27485  0.36095   31.33888  1.000 34.87578  ?  583  ALA A CB  1 
ATOM   4447 N  N   . GLY A 1 584 ? -6.62463  -1.60445  31.79188  1.000 30.91332  ?  584  GLY A N   1 
ATOM   4448 C  CA  . GLY A 1 584 ? -6.05376  -2.89830  32.11025  1.000 35.49091  ?  584  GLY A CA  1 
ATOM   4449 C  C   . GLY A 1 584 ? -5.28057  -2.95006  33.42424  1.000 37.70873  ?  584  GLY A C   1 
ATOM   4450 O  O   . GLY A 1 584 ? -4.90889  -4.05236  33.84761  1.000 35.88329  ?  584  GLY A O   1 
ATOM   4451 N  N   . ARG A 1 585 ? -5.01452  -1.80268  34.06295  1.000 29.26208  ?  585  ARG A N   1 
ATOM   4452 C  CA  . ARG A 1 585 ? -4.45181  -1.77174  35.40991  1.000 27.13900  ?  585  ARG A CA  1 
ATOM   4453 C  C   . ARG A 1 585 ? -5.49435  -1.43401  36.46445  1.000 29.89527  ?  585  ARG A C   1 
ATOM   4454 O  O   . ARG A 1 585 ? -5.14356  -1.09929  37.60235  1.000 31.82765  ?  585  ARG A O   1 
ATOM   4455 C  CB  . ARG A 1 585 ? -3.29820  -0.77283  35.48890  1.000 29.53520  ?  585  ARG A CB  1 
ATOM   4456 C  CG  . ARG A 1 585 ? -2.00341  -1.30014  34.92720  1.000 33.16340  ?  585  ARG A CG  1 
ATOM   4457 C  CD  . ARG A 1 585 ? -1.87405  -0.99175  33.42013  1.000 32.03004  ?  585  ARG A CD  1 
ATOM   4458 N  NE  . ARG A 1 585 ? -0.85506  -1.86170  32.86363  1.000 37.29279  ?  585  ARG A NE  1 
ATOM   4459 C  CZ  . ARG A 1 585 ? -1.05018  -2.74284  31.89428  1.000 42.60003  ?  585  ARG A CZ  1 
ATOM   4460 N  NH1 . ARG A 1 585 ? -2.17210  -2.75931  31.18772  1.000 37.10391  ?  585  ARG A NH1 1 
ATOM   4461 N  NH2 . ARG A 1 585 ? -0.09434  -3.63490  31.63062  1.000 41.49272  ?  585  ARG A NH2 1 
ATOM   4462 N  N   . CYS A 1 586 ? -6.76057  -1.46960  36.10178  1.000 31.42481  ?  586  CYS A N   1 
ATOM   4463 C  CA  . CYS A 1 586 ? -7.85709  -1.12693  36.98912  1.000 31.29588  ?  586  CYS A CA  1 
ATOM   4464 C  C   . CYS A 1 586 ? -8.73403  -2.36020  37.11270  1.000 33.86339  ?  586  CYS A C   1 
ATOM   4465 O  O   . CYS A 1 586 ? -9.30003  -2.81947  36.11180  1.000 39.53697  ?  586  CYS A O   1 
ATOM   4466 C  CB  . CYS A 1 586 ? -8.64090  0.06315   36.43812  1.000 31.27689  ?  586  CYS A CB  1 
ATOM   4467 S  SG  . CYS A 1 586 ? -9.97892  0.66535   37.49393  1.000 31.88095  ?  586  CYS A SG  1 
ATOM   4468 N  N   . ASN A 1 587 ? -8.83587  -2.90027  38.32542  1.000 34.50311  ?  587  ASN A N   1 
ATOM   4469 C  CA  . ASN A 1 587 ? -9.46896  -4.20518  38.54601  1.000 33.46500  ?  587  ASN A CA  1 
ATOM   4470 C  C   . ASN A 1 587 ? -8.98721  -5.19564  37.48957  1.000 35.79968  ?  587  ASN A C   1 
ATOM   4471 O  O   . ASN A 1 587 ? -9.78344  -5.80308  36.76967  1.000 34.08037  ?  587  ASN A O   1 
ATOM   4472 C  CB  . ASN A 1 587 ? -10.99740 -4.10767  38.54835  1.000 32.65966  ?  587  ASN A CB  1 
ATOM   4473 C  CG  . ASN A 1 587 ? -11.68890 -5.44326  38.95391  1.000 35.76099  ?  587  ASN A CG  1 
ATOM   4474 O  OD1 . ASN A 1 587 ? -11.15061 -6.23375  39.72617  1.000 30.81036  ?  587  ASN A OD1 1 
ATOM   4475 N  ND2 . ASN A 1 587 ? -12.88748 -5.66786  38.43248  1.000 32.47041  ?  587  ASN A ND2 1 
ATOM   4476 N  N   . ARG A 1 588 ? -7.65321  -5.34004  37.40251  1.000 35.61672  ?  588  ARG A N   1 
ATOM   4477 C  CA  . ARG A 1 588 ? -7.02709  -6.07959  36.30334  1.000 37.02442  ?  588  ARG A CA  1 
ATOM   4478 C  C   . ARG A 1 588 ? -7.54972  -7.51308  36.21126  1.000 36.34260  ?  588  ARG A C   1 
ATOM   4479 O  O   . ARG A 1 588 ? -7.99087  -7.95424  35.14598  1.000 40.75414  ?  588  ARG A O   1 
ATOM   4480 C  CB  . ARG A 1 588 ? -5.50150  -6.07664  36.46685  1.000 34.98516  ?  588  ARG A CB  1 
ATOM   4481 C  CG  . ARG A 1 588 ? -4.71177  -6.87189  35.37018  1.000 37.65315  ?  588  ARG A CG  1 
ATOM   4482 C  CD  . ARG A 1 588 ? -3.22842  -6.49880  35.40024  1.000 41.94420  ?  588  ARG A CD  1 
ATOM   4483 N  NE  . ARG A 1 588 ? -2.41156  -7.19125  34.40910  1.000 40.07140  ?  588  ARG A NE  1 
ATOM   4484 C  CZ  . ARG A 1 588 ? -2.25882  -6.81310  33.14497  1.000 38.00491  ?  588  ARG A CZ  1 
ATOM   4485 N  NH1 . ARG A 1 588 ? -2.89210  -5.75895  32.65240  1.000 34.96393  ?  588  ARG A NH1 1 
ATOM   4486 N  NH2 . ARG A 1 588 ? -1.45626  -7.51804  32.35140  1.000 42.48171  ?  588  ARG A NH2 1 
ATOM   4487 N  N   . GLU A 1 589 ? -7.51312  -8.24961  37.31673  1.000 35.35429  ?  589  GLU A N   1 
ATOM   4488 C  CA  . GLU A 1 589 ? -7.95548  -9.64091  37.32405  1.000 44.99436  ?  589  GLU A CA  1 
ATOM   4489 C  C   . GLU A 1 589 ? -9.47328  -9.78095  37.35230  1.000 43.31968  ?  589  GLU A C   1 
ATOM   4490 O  O   . GLU A 1 589 ? -9.97634  -10.88700 37.19388  1.000 46.85572  ?  589  GLU A O   1 
ATOM   4491 C  CB  . GLU A 1 589 ? -7.36779  -10.37079 38.54275  1.000 48.68299  ?  589  GLU A CB  1 
ATOM   4492 C  CG  . GLU A 1 589 ? -5.84093  -10.45976 38.59617  1.000 50.75864  ?  589  GLU A CG  1 
ATOM   4493 C  CD  . GLU A 1 589 ? -5.30195  -11.69340 37.90414  1.000 63.28297  ?  589  GLU A CD  1 
ATOM   4494 O  OE1 . GLU A 1 589 ? -5.67302  -12.82866 38.28841  1.000 69.39282  ?  589  GLU A OE1 1 
ATOM   4495 O  OE2 . GLU A 1 589 ? -4.51764  -11.52366 36.95067  1.000 65.70887  -1 589  GLU A OE2 1 
ATOM   4496 N  N   . GLY A 1 590 ? -10.22023 -8.70000  37.54640  1.000 44.11569  ?  590  GLY A N   1 
ATOM   4497 C  CA  . GLY A 1 590 ? -11.64644 -8.85449  37.74359  1.000 39.77404  ?  590  GLY A CA  1 
ATOM   4498 C  C   . GLY A 1 590 ? -12.00570 -9.50818  39.06577  1.000 45.71519  ?  590  GLY A C   1 
ATOM   4499 O  O   . GLY A 1 590 ? -13.03022 -10.19033 39.15305  1.000 45.62893  ?  590  GLY A O   1 
ATOM   4500 N  N   . LYS A 1 591 ? -11.17002 -9.34024  40.09431  1.000 43.69929  ?  591  LYS A N   1 
ATOM   4501 C  CA  . LYS A 1 591 ? -11.39125 -9.93046  41.40506  1.000 44.67910  ?  591  LYS A CA  1 
ATOM   4502 C  C   . LYS A 1 591 ? -12.07861 -8.98142  42.38148  1.000 44.95154  ?  591  LYS A C   1 
ATOM   4503 O  O   . LYS A 1 591 ? -12.29932 -9.35940  43.53709  1.000 46.24058  ?  591  LYS A O   1 
ATOM   4504 C  CB  . LYS A 1 591 ? -10.06061 -10.38244 42.01174  1.000 48.54832  ?  591  LYS A CB  1 
ATOM   4505 C  CG  . LYS A 1 591 ? -9.30427  -11.41179 41.20922  1.000 51.99185  ?  591  LYS A CG  1 
ATOM   4506 C  CD  . LYS A 1 591 ? -8.28078  -12.15042 42.08137  1.000 56.33790  ?  591  LYS A CD  1 
ATOM   4507 C  CE  . LYS A 1 591 ? -8.81218  -13.52127 42.53171  1.000 69.86505  ?  591  LYS A CE  1 
ATOM   4508 N  NZ  . LYS A 1 591 ? -9.69849  -14.17375 41.51392  1.000 62.90758  ?  591  LYS A NZ  1 
ATOM   4509 N  N   . LEU A 1 592 ? -12.40586 -7.79389  41.96855  1.000 42.48945  ?  592  LEU A N   1 
ATOM   4510 C  CA  . LEU A 1 592 ? -12.95761 -6.99871  43.05296  1.000 41.47109  ?  592  LEU A CA  1 
ATOM   4511 C  C   . LEU A 1 592 ? -14.48110 -7.08060  43.05969  1.000 35.41108  ?  592  LEU A C   1 
ATOM   4512 O  O   . LEU A 1 592 ? -15.10297 -7.24473  42.00667  1.000 41.99476  ?  592  LEU A O   1 
ATOM   4513 C  CB  . LEU A 1 592 ? -12.51717 -5.54443  42.91551  1.000 38.80332  ?  592  LEU A CB  1 
ATOM   4514 C  CG  . LEU A 1 592 ? -11.00327 -5.36202  43.03626  1.000 41.00751  ?  592  LEU A CG  1 
ATOM   4515 C  CD1 . LEU A 1 592 ? -10.59762 -4.07772  42.37248  1.000 31.28773  ?  592  LEU A CD1 1 
ATOM   4516 C  CD2 . LEU A 1 592 ? -10.50521 -5.40520  44.50169  1.000 39.08739  ?  592  LEU A CD2 1 
ATOM   4517 N  N   . PRO A 1 593 ? -15.10155 -6.95838  44.23768  1.000 33.35708  ?  593  PRO A N   1 
ATOM   4518 C  CA  . PRO A 1 593 ? -16.57046 -6.99544  44.32488  1.000 29.14217  ?  593  PRO A CA  1 
ATOM   4519 C  C   . PRO A 1 593 ? -17.25232 -5.73814  43.81561  1.000 38.66651  ?  593  PRO A C   1 
ATOM   4520 O  O   . PRO A 1 593 ? -18.47800 -5.61941  43.93646  1.000 36.97178  ?  593  PRO A O   1 
ATOM   4521 C  CB  . PRO A 1 593 ? -16.82692 -7.16172  45.82733  1.000 34.66059  ?  593  PRO A CB  1 
ATOM   4522 C  CG  . PRO A 1 593 ? -15.61375 -6.54975  46.47738  1.000 34.09223  ?  593  PRO A CG  1 
ATOM   4523 C  CD  . PRO A 1 593 ? -14.45947 -6.77580  45.54988  1.000 34.38545  ?  593  PRO A CD  1 
ATOM   4524 N  N   . GLN A 1 594 ? -16.51594 -4.76106  43.29559  1.000 37.26786  ?  594  GLN A N   1 
ATOM   4525 C  CA  . GLN A 1 594 ? -17.14952 -3.66769  42.57382  1.000 34.45983  ?  594  GLN A CA  1 
ATOM   4526 C  C   . GLN A 1 594 ? -16.36300 -3.43368  41.29600  1.000 33.86565  ?  594  GLN A C   1 
ATOM   4527 O  O   . GLN A 1 594 ? -15.18777 -3.80622  41.19897  1.000 33.15599  ?  594  GLN A O   1 
ATOM   4528 C  CB  . GLN A 1 594 ? -17.22527 -2.39702  43.42243  1.000 36.07325  ?  594  GLN A CB  1 
ATOM   4529 C  CG  . GLN A 1 594 ? -17.92729 -2.59284  44.77493  1.000 34.80721  ?  594  GLN A CG  1 
ATOM   4530 C  CD  . GLN A 1 594 ? -19.39987 -2.22872  44.72625  1.000 34.22849  ?  594  GLN A CD  1 
ATOM   4531 O  OE1 . GLN A 1 594 ? -19.77655 -1.08436  44.42425  1.000 36.01330  ?  594  GLN A OE1 1 
ATOM   4532 N  NE2 . GLN A 1 594 ? -20.23800 -3.19490  45.01673  1.000 27.84978  ?  594  GLN A NE2 1 
ATOM   4533 N  N   . LEU A 1 595 ? -17.03529 -2.84339  40.30363  1.000 34.74275  ?  595  LEU A N   1 
ATOM   4534 C  CA  . LEU A 1 595 ? -16.33675 -2.40500  39.10339  1.000 38.09106  ?  595  LEU A CA  1 
ATOM   4535 C  C   . LEU A 1 595 ? -15.23913 -1.40863  39.45500  1.000 39.02407  ?  595  LEU A C   1 
ATOM   4536 O  O   . LEU A 1 595 ? -15.37280 -0.59778  40.37813  1.000 37.01552  ?  595  LEU A O   1 
ATOM   4537 C  CB  . LEU A 1 595 ? -17.29186 -1.74541  38.11230  1.000 35.74746  ?  595  LEU A CB  1 
ATOM   4538 C  CG  . LEU A 1 595 ? -18.39098 -2.62785  37.54353  1.000 36.70401  ?  595  LEU A CG  1 
ATOM   4539 C  CD1 . LEU A 1 595 ? -19.58959 -1.76645  37.15802  1.000 35.63229  ?  595  LEU A CD1 1 
ATOM   4540 C  CD2 . LEU A 1 595 ? -17.85297 -3.40578  36.36744  1.000 39.44221  ?  595  LEU A CD2 1 
ATOM   4541 N  N   . GLY A 1 596 ? -14.14175 -1.47631  38.70172  1.000 33.19923  ?  596  GLY A N   1 
ATOM   4542 C  CA  . GLY A 1 596 ? -13.14556 -0.42889  38.77390  1.000 37.48334  ?  596  GLY A CA  1 
ATOM   4543 C  C   . GLY A 1 596 ? -13.67225 0.88517   38.22641  1.000 37.46533  ?  596  GLY A C   1 
ATOM   4544 O  O   . GLY A 1 596 ? -14.61931 0.93831   37.43892  1.000 33.94785  ?  596  GLY A O   1 
ATOM   4545 N  N   . GLU A 1 597 ? -13.05152 1.97017   38.67092  1.000 36.48537  ?  597  GLU A N   1 
ATOM   4546 C  CA  . GLU A 1 597 ? -13.44213 3.32172   38.28238  1.000 36.00259  ?  597  GLU A CA  1 
ATOM   4547 C  C   . GLU A 1 597 ? -12.32543 3.89311   37.41352  1.000 30.67187  ?  597  GLU A C   1 
ATOM   4548 O  O   . GLU A 1 597 ? -11.20285 4.08214   37.89106  1.000 31.51381  ?  597  GLU A O   1 
ATOM   4549 C  CB  . GLU A 1 597 ? -13.69967 4.18759   39.52558  1.000 34.50190  ?  597  GLU A CB  1 
ATOM   4550 C  CG  . GLU A 1 597 ? -13.95315 5.66555   39.21126  1.000 36.09187  ?  597  GLU A CG  1 
ATOM   4551 C  CD  . GLU A 1 597 ? -14.19784 6.57971   40.45476  1.000 45.77374  ?  597  GLU A CD  1 
ATOM   4552 O  OE1 . GLU A 1 597 ? -13.47514 6.50127   41.48080  1.000 39.08009  ?  597  GLU A OE1 1 
ATOM   4553 O  OE2 . GLU A 1 597 ? -15.09133 7.45455   40.36039  1.000 50.93642  -1 597  GLU A OE2 1 
ATOM   4554 N  N   . VAL A 1 598 ? -12.61579 4.16812   36.14102  1.000 31.79758  ?  598  VAL A N   1 
ATOM   4555 C  CA  . VAL A 1 598 ? -11.63182 4.76983   35.23722  1.000 31.81050  ?  598  VAL A CA  1 
ATOM   4556 C  C   . VAL A 1 598 ? -12.11467 6.16416   34.86137  1.000 33.84673  ?  598  VAL A C   1 
ATOM   4557 O  O   . VAL A 1 598 ? -13.24854 6.33423   34.41097  1.000 36.95097  ?  598  VAL A O   1 
ATOM   4558 C  CB  . VAL A 1 598 ? -11.38839 3.89851   33.99083  1.000 34.52253  ?  598  VAL A CB  1 
ATOM   4559 C  CG1 . VAL A 1 598 ? -10.42164 4.57227   33.03943  1.000 27.30766  ?  598  VAL A CG1 1 
ATOM   4560 C  CG2 . VAL A 1 598 ? -10.82441 2.54326   34.40853  1.000 28.55611  ?  598  VAL A CG2 1 
ATOM   4561 N  N   . VAL A 1 599 ? -11.27159 7.16451   35.07135  1.000 29.47411  ?  599  VAL A N   1 
ATOM   4562 C  CA  . VAL A 1 599 ? -11.63271 8.54779   34.77725  1.000 32.36056  ?  599  VAL A CA  1 
ATOM   4563 C  C   . VAL A 1 599 ? -10.63307 9.06916   33.75718  1.000 30.45735  ?  599  VAL A C   1 
ATOM   4564 O  O   . VAL A 1 599 ? -9.43383  9.14027   34.04087  1.000 30.67120  ?  599  VAL A O   1 
ATOM   4565 C  CB  . VAL A 1 599 ? -11.64833 9.43812   36.02551  1.000 33.91988  ?  599  VAL A CB  1 
ATOM   4566 C  CG1 . VAL A 1 599 ? -11.71639 10.88982  35.60813  1.000 35.22880  ?  599  VAL A CG1 1 
ATOM   4567 C  CG2 . VAL A 1 599 ? -12.84907 9.10405   36.91912  1.000 34.91414  ?  599  VAL A CG2 1 
ATOM   4568 N  N   . VAL A 1 600 ? -11.10990 9.37310   32.55313  1.000 31.24546  ?  600  VAL A N   1 
ATOM   4569 C  CA  . VAL A 1 600 ? -10.27828 10.00130  31.53358  1.000 33.02120  ?  600  VAL A CA  1 
ATOM   4570 C  C   . VAL A 1 600 ? -10.48283 11.49817  31.67970  1.000 28.20365  ?  600  VAL A C   1 
ATOM   4571 O  O   . VAL A 1 600 ? -11.62225 11.96619  31.72708  1.000 32.06780  ?  600  VAL A O   1 
ATOM   4572 C  CB  . VAL A 1 600 ? -10.64583 9.51433   30.11744  1.000 33.54575  ?  600  VAL A CB  1 
ATOM   4573 C  CG1 . VAL A 1 600 ? -9.76825  10.22765  29.05315  1.000 31.39324  ?  600  VAL A CG1 1 
ATOM   4574 C  CG2 . VAL A 1 600 ? -10.48984 7.99788   30.00754  1.000 28.26601  ?  600  VAL A CG2 1 
ATOM   4575 N  N   . PHE A 1 601 ? -9.38973  12.23912  31.80651  1.000 30.88938  ?  601  PHE A N   1 
ATOM   4576 C  CA  . PHE A 1 601 ? -9.47392  13.68037  32.03120  1.000 34.32114  ?  601  PHE A CA  1 
ATOM   4577 C  C   . PHE A 1 601 ? -8.71668  14.39836  30.92748  1.000 34.04822  ?  601  PHE A C   1 
ATOM   4578 O  O   . PHE A 1 601 ? -7.82038  13.83723  30.28142  1.000 32.15458  ?  601  PHE A O   1 
ATOM   4579 C  CB  . PHE A 1 601 ? -8.91145  14.09858  33.42610  1.000 24.33472  ?  601  PHE A CB  1 
ATOM   4580 C  CG  . PHE A 1 601 ? -7.46690  13.68192  33.64659  1.000 31.55086  ?  601  PHE A CG  1 
ATOM   4581 C  CD1 . PHE A 1 601 ? -7.16506  12.42173  34.16850  1.000 29.57916  ?  601  PHE A CD1 1 
ATOM   4582 C  CD2 . PHE A 1 601 ? -6.41077  14.54291  33.32729  1.000 28.62655  ?  601  PHE A CD2 1 
ATOM   4583 C  CE1 . PHE A 1 601 ? -5.84678  12.02196  34.35418  1.000 25.01184  ?  601  PHE A CE1 1 
ATOM   4584 C  CE2 . PHE A 1 601 ? -5.09591  14.15384  33.51435  1.000 33.17804  ?  601  PHE A CE2 1 
ATOM   4585 C  CZ  . PHE A 1 601 ? -4.80694  12.88285  34.02052  1.000 29.81375  ?  601  PHE A CZ  1 
ATOM   4586 N  N   . ARG A 1 602 ? -9.08814  15.65139  30.72138  1.000 31.90966  ?  602  ARG A N   1 
ATOM   4587 C  CA  . ARG A 1 602 ? -8.40760  16.51870  29.77733  1.000 31.53252  ?  602  ARG A CA  1 
ATOM   4588 C  C   . ARG A 1 602 ? -7.65026  17.56749  30.58533  1.000 33.52404  ?  602  ARG A C   1 
ATOM   4589 O  O   . ARG A 1 602 ? -8.25932  18.40594  31.26294  1.000 32.15635  ?  602  ARG A O   1 
ATOM   4590 C  CB  . ARG A 1 602 ? -9.39397  17.15423  28.79945  1.000 35.45963  ?  602  ARG A CB  1 
ATOM   4591 C  CG  . ARG A 1 602 ? -8.73624  18.19518  27.82428  1.000 36.72380  ?  602  ARG A CG  1 
ATOM   4592 C  CD  . ARG A 1 602 ? -9.78304  18.92633  26.94547  1.000 36.93531  ?  602  ARG A CD  1 
ATOM   4593 N  NE  . ARG A 1 602 ? -10.61061 17.99621  26.17816  1.000 38.63157  ?  602  ARG A NE  1 
ATOM   4594 C  CZ  . ARG A 1 602 ? -11.87795 17.72540  26.45612  1.000 40.82388  ?  602  ARG A CZ  1 
ATOM   4595 N  NH1 . ARG A 1 602 ? -12.50114 18.31038  27.46965  1.000 37.82187  ?  602  ARG A NH1 1 
ATOM   4596 N  NH2 . ARG A 1 602 ? -12.53817 16.85378  25.69540  1.000 35.07312  ?  602  ARG A NH2 1 
ATOM   4597 N  N   . ALA A 1 603 ? -6.32863  17.50609  30.53057  1.000 32.08683  ?  603  ALA A N   1 
ATOM   4598 C  CA  . ALA A 1 603 ? -5.47191  18.48865  31.17162  1.000 38.13643  ?  603  ALA A CA  1 
ATOM   4599 C  C   . ALA A 1 603 ? -4.76846  19.31151  30.10252  1.000 36.19542  ?  603  ALA A C   1 
ATOM   4600 O  O   . ALA A 1 603 ? -5.12467  19.25946  28.92550  1.000 40.19133  ?  603  ALA A O   1 
ATOM   4601 C  CB  . ALA A 1 603 ? -4.47581  17.80561  32.09839  1.000 36.83188  ?  603  ALA A CB  1 
ATOM   4602 N  N   . GLU A 1 604 ? -3.79613  20.10818  30.53529  1.000 37.74789  ?  604  GLU A N   1 
ATOM   4603 C  CA  . GLU A 1 604 ? -2.80486  20.73845  29.66522  1.000 42.10810  ?  604  GLU A CA  1 
ATOM   4604 C  C   . GLU A 1 604 ? -2.36697  19.80467  28.53848  1.000 46.61270  ?  604  GLU A C   1 
ATOM   4605 O  O   . GLU A 1 604 ? -2.04034  18.64009  28.76182  1.000 42.70458  ?  604  GLU A O   1 
ATOM   4606 C  CB  . GLU A 1 604 ? -1.59406  21.14376  30.51978  1.000 44.93546  ?  604  GLU A CB  1 
ATOM   4607 C  CG  . GLU A 1 604 ? -0.30020  21.53376  29.79998  1.000 48.14552  ?  604  GLU A CG  1 
ATOM   4608 C  CD  . GLU A 1 604 ? 0.95664   21.47441  30.73140  1.000 50.12187  ?  604  GLU A CD  1 
ATOM   4609 O  OE1 . GLU A 1 604 ? 2.09986   21.30202  30.19945  1.000 51.74185  ?  604  GLU A OE1 1 
ATOM   4610 O  OE2 . GLU A 1 604 ? 0.80762   21.54967  31.97748  1.000 45.56258  -1 604  GLU A OE2 1 
ATOM   4611 N  N   . GLU A 1 605 ? -2.37468  20.32252  27.31919  1.000 53.30388  ?  605  GLU A N   1 
ATOM   4612 C  CA  . GLU A 1 605 ? -2.00854  19.51669  26.16462  1.000 51.61948  ?  605  GLU A CA  1 
ATOM   4613 C  C   . GLU A 1 605 ? -0.54313  19.09599  26.23763  1.000 56.80460  ?  605  GLU A C   1 
ATOM   4614 O  O   . GLU A 1 605 ? 0.29889   19.78510  26.82873  1.000 57.17612  ?  605  GLU A O   1 
ATOM   4615 C  CB  . GLU A 1 605 ? -2.26188  20.30348  24.87621  1.000 56.26020  ?  605  GLU A CB  1 
ATOM   4616 C  CG  . GLU A 1 605 ? -1.17683  21.32745  24.55522  1.000 62.96665  ?  605  GLU A CG  1 
ATOM   4617 C  CD  . GLU A 1 605 ? -0.06062  20.75115  23.67819  1.000 70.95708  ?  605  GLU A CD  1 
ATOM   4618 O  OE1 . GLU A 1 605 ? -0.36970  20.20597  22.58192  1.000 67.08039  ?  605  GLU A OE1 1 
ATOM   4619 O  OE2 . GLU A 1 605 ? 1.12171   20.82215  24.10285  1.000 68.10281  -1 605  GLU A OE2 1 
ATOM   4620 N  N   . GLY A 1 606 ? -0.24177  17.96495  25.61011  1.000 53.41064  ?  606  GLY A N   1 
ATOM   4621 C  CA  . GLY A 1 606 ? 1.11800   17.47331  25.48478  1.000 52.06293  ?  606  GLY A CA  1 
ATOM   4622 C  C   . GLY A 1 606 ? 1.12912   16.00013  25.14818  1.000 49.96048  ?  606  GLY A C   1 
ATOM   4623 O  O   . GLY A 1 606 ? 0.17204   15.27101  25.42101  1.000 45.71221  ?  606  GLY A O   1 
ATOM   4624 N  N   . ALA A 1 607 ? 2.24374   15.56065  24.51602  1.000 45.72354  ?  607  ALA A N   1 
ATOM   4625 C  CA  . ALA A 1 607 ? 2.44417   14.15767  24.14123  1.000 49.45649  ?  607  ALA A CA  1 
ATOM   4626 C  C   . ALA A 1 607 ? 3.89236   13.92084  23.71542  1.000 51.83100  ?  607  ALA A C   1 
ATOM   4627 O  O   . ALA A 1 607 ? 4.50496   14.80411  23.10237  1.000 51.89848  ?  607  ALA A O   1 
ATOM   4628 C  CB  . ALA A 1 607 ? 1.48951   13.74578  23.01342  1.000 52.00212  ?  607  ALA A CB  1 
ATOM   4629 N  N   . PRO A 1 608 ? 4.46631   12.74107  23.99591  1.000 49.13743  ?  608  PRO A N   1 
ATOM   4630 C  CA  . PRO A 1 608 ? 5.89911   12.52088  23.72702  1.000 48.37769  ?  608  PRO A CA  1 
ATOM   4631 C  C   . PRO A 1 608 ? 6.23950   12.25470  22.27184  1.000 49.63076  ?  608  PRO A C   1 
ATOM   4632 O  O   . PRO A 1 608 ? 7.43330   12.18959  21.94385  1.000 45.55204  ?  608  PRO A O   1 
ATOM   4633 C  CB  . PRO A 1 608 ? 6.24774   11.28753  24.59228  1.000 47.15664  ?  608  PRO A CB  1 
ATOM   4634 C  CG  . PRO A 1 608 ? 4.97289   10.81146  25.19367  1.000 49.48573  ?  608  PRO A CG  1 
ATOM   4635 C  CD  . PRO A 1 608 ? 3.82127   11.53792  24.53514  1.000 48.66514  ?  608  PRO A CD  1 
ATOM   4636 N  N   . SER A 1 609 ? 5.25176   12.09332  21.39315  1.000 47.91930  ?  609  SER A N   1 
ATOM   4637 C  CA  . SER A 1 609 ? 5.55090   11.88590  19.98359  1.000 47.18746  ?  609  SER A CA  1 
ATOM   4638 C  C   . SER A 1 609 ? 4.34022   12.31544  19.17686  1.000 48.38823  ?  609  SER A C   1 
ATOM   4639 O  O   . SER A 1 609 ? 3.21043   12.29106  19.67586  1.000 47.28235  ?  609  SER A O   1 
ATOM   4640 C  CB  . SER A 1 609 ? 5.90905   10.42573  19.68235  1.000 49.52511  ?  609  SER A CB  1 
ATOM   4641 O  OG  . SER A 1 609 ? 4.76580   9.70845   19.23950  1.000 45.42540  ?  609  SER A OG  1 
ATOM   4642 N  N   . GLY A 1 610 ? 4.59313   12.70197  17.92049  1.000 50.22031  ?  610  GLY A N   1 
ATOM   4643 C  CA  . GLY A 1 610 ? 3.51328   13.13095  17.05086  1.000 40.96394  ?  610  GLY A CA  1 
ATOM   4644 C  C   . GLY A 1 610 ? 2.44762   12.07338  16.89097  1.000 42.25386  ?  610  GLY A C   1 
ATOM   4645 O  O   . GLY A 1 610 ? 1.26333   12.39388  16.71962  1.000 40.48400  ?  610  GLY A O   1 
ATOM   4646 N  N   . SER A 1 611 ? 2.83757   10.79901  16.99397  1.000 39.37328  ?  611  SER A N   1 
ATOM   4647 C  CA  . SER A 1 611 ? 1.86188   9.72999   16.82139  1.000 41.74185  ?  611  SER A CA  1 
ATOM   4648 C  C   . SER A 1 611 ? 0.91276   9.64274   18.00776  1.000 43.28118  ?  611  SER A C   1 
ATOM   4649 O  O   . SER A 1 611 ? -0.28417  9.36367   17.83855  1.000 44.57424  ?  611  SER A O   1 
ATOM   4650 C  CB  . SER A 1 611 ? 2.57552   8.40373   16.59506  1.000 40.10667  ?  611  SER A CB  1 
ATOM   4651 O  OG  . SER A 1 611 ? 1.91508   7.69403   15.56564  1.000 52.06302  ?  611  SER A OG  1 
ATOM   4652 N  N   . LEU A 1 612 ? 1.42085   9.87781   19.21965  1.000 45.23959  ?  612  LEU A N   1 
ATOM   4653 C  CA  . LEU A 1 612 ? 0.54716   9.83359   20.38560  1.000 43.74825  ?  612  LEU A CA  1 
ATOM   4654 C  C   . LEU A 1 612 ? -0.37689  11.05107  20.42049  1.000 42.82675  ?  612  LEU A C   1 
ATOM   4655 O  O   . LEU A 1 612 ? -1.54609  10.95245  20.82623  1.000 38.18404  ?  612  LEU A O   1 
ATOM   4656 C  CB  . LEU A 1 612 ? 1.39770   9.70946   21.65039  1.000 47.85735  ?  612  LEU A CB  1 
ATOM   4657 C  CG  . LEU A 1 612 ? 1.94570   8.28297   21.89710  1.000 47.44508  ?  612  LEU A CG  1 
ATOM   4658 C  CD1 . LEU A 1 612 ? 3.41887   8.16857   21.55138  1.000 47.96068  ?  612  LEU A CD1 1 
ATOM   4659 C  CD2 . LEU A 1 612 ? 1.73877   7.85670   23.33384  1.000 54.14804  ?  612  LEU A CD2 1 
ATOM   4660 N  N   . LYS A 1 613 ? 0.11701   12.19584  19.95211  1.000 38.08437  ?  613  LYS A N   1 
ATOM   4661 C  CA  . LYS A 1 613 ? -0.75889  13.33382  19.71354  1.000 40.35178  ?  613  LYS A CA  1 
ATOM   4662 C  C   . LYS A 1 613 ? -1.85277  12.98401  18.70541  1.000 39.75821  ?  613  LYS A C   1 
ATOM   4663 O  O   . LYS A 1 613 ? -3.00993  13.38422  18.87622  1.000 39.27663  ?  613  LYS A O   1 
ATOM   4664 C  CB  . LYS A 1 613 ? 0.06930   14.52762  19.23537  1.000 41.74515  ?  613  LYS A CB  1 
ATOM   4665 C  CG  . LYS A 1 613 ? -0.75269  15.68186  18.72668  1.000 49.33711  ?  613  LYS A CG  1 
ATOM   4666 C  CD  . LYS A 1 613 ? -1.34651  16.48527  19.88258  1.000 50.29483  ?  613  LYS A CD  1 
ATOM   4667 C  CE  . LYS A 1 613 ? -1.43722  17.97524  19.54186  1.000 57.76807  ?  613  LYS A CE  1 
ATOM   4668 N  NZ  . LYS A 1 613 ? -2.77610  18.32322  18.95076  1.000 54.93154  ?  613  LYS A NZ  1 
ATOM   4669 N  N   . GLN A 1 614 ? -1.51488  12.22352  17.65426  1.000 41.06257  ?  614  GLN A N   1 
ATOM   4670 C  CA  . GLN A 1 614 ? -2.54003  11.82332  16.69086  1.000 36.63514  ?  614  GLN A CA  1 
ATOM   4671 C  C   . GLN A 1 614 ? -3.61967  10.96923  17.35232  1.000 37.76009  ?  614  GLN A C   1 
ATOM   4672 O  O   . GLN A 1 614 ? -4.82122  11.17820  17.11641  1.000 38.07509  ?  614  GLN A O   1 
ATOM   4673 C  CB  . GLN A 1 614 ? -1.93003  11.07899  15.50001  1.000 33.13842  ?  614  GLN A CB  1 
ATOM   4674 C  CG  . GLN A 1 614 ? -3.00578  10.71700  14.43518  1.000 42.92742  ?  614  GLN A CG  1 
ATOM   4675 C  CD  . GLN A 1 614 ? -2.46120  10.19382  13.09582  1.000 44.33403  ?  614  GLN A CD  1 
ATOM   4676 O  OE1 . GLN A 1 614 ? -1.68077  10.86771  12.40071  1.000 46.18736  ?  614  GLN A OE1 1 
ATOM   4677 N  NE2 . GLN A 1 614 ? -2.88931  8.98368   12.72582  1.000 42.34309  ?  614  GLN A NE2 1 
ATOM   4678 N  N   . GLY A 1 615 ? -3.21468  10.00090  18.17351  1.000 35.07821  ?  615  GLY A N   1 
ATOM   4679 C  CA  . GLY A 1 615 ? -4.20442  9.23426   18.91972  1.000 35.14548  ?  615  GLY A CA  1 
ATOM   4680 C  C   . GLY A 1 615 ? -5.10754  10.13508  19.75514  1.000 34.90098  ?  615  GLY A C   1 
ATOM   4681 O  O   . GLY A 1 615 ? -6.32977  9.96024   19.79011  1.000 34.01104  ?  615  GLY A O   1 
ATOM   4682 N  N   . GLN A 1 616 ? -4.51270  11.11376  20.43777  1.000 35.99611  ?  616  GLN A N   1 
ATOM   4683 C  CA  . GLN A 1 616 ? -5.30385  12.02002  21.25961  1.000 36.15853  ?  616  GLN A CA  1 
ATOM   4684 C  C   . GLN A 1 616 ? -6.34063  12.73653  20.40764  1.000 29.16770  ?  616  GLN A C   1 
ATOM   4685 O  O   . GLN A 1 616 ? -7.51842  12.82372  20.78330  1.000 31.75658  ?  616  GLN A O   1 
ATOM   4686 C  CB  . GLN A 1 616 ? -4.36576  13.00059  21.95886  1.000 32.28759  ?  616  GLN A CB  1 
ATOM   4687 C  CG  . GLN A 1 616 ? -4.92473  13.72880  23.15990  1.000 38.60032  ?  616  GLN A CG  1 
ATOM   4688 C  CD  . GLN A 1 616 ? -3.81971  14.41870  24.00249  1.000 40.26435  ?  616  GLN A CD  1 
ATOM   4689 O  OE1 . GLN A 1 616 ? -2.73736  14.70822  23.50338  1.000 42.74814  ?  616  GLN A OE1 1 
ATOM   4690 N  NE2 . GLN A 1 616 ? -4.10545  14.66333  25.28847  1.000 40.15296  ?  616  GLN A NE2 1 
ATOM   4691 N  N   . ASP A 1 617 ? -5.92461  13.19648  19.22461  1.000 32.35365  ?  617  ASP A N   1 
ATOM   4692 C  CA  . ASP A 1 617 ? -6.82338  13.93879  18.34672  1.000 35.34041  ?  617  ASP A CA  1 
ATOM   4693 C  C   . ASP A 1 617 ? -7.96766  13.06084  17.88196  1.000 32.16387  ?  617  ASP A C   1 
ATOM   4694 O  O   . ASP A 1 617 ? -9.11797  13.51484  17.81861  1.000 30.09318  ?  617  ASP A O   1 
ATOM   4695 C  CB  . ASP A 1 617 ? -6.06377  14.49959  17.13993  1.000 34.62295  ?  617  ASP A CB  1 
ATOM   4696 C  CG  . ASP A 1 617 ? -5.04529  15.57050  17.52412  1.000 40.22586  ?  617  ASP A CG  1 
ATOM   4697 O  OD1 . ASP A 1 617 ? -5.10731  16.07538  18.65772  1.000 46.99704  -1 617  ASP A OD1 1 
ATOM   4698 O  OD2 . ASP A 1 617 ? -4.17641  15.91318  16.69173  1.000 49.03245  -1 617  ASP A OD2 1 
ATOM   4699 N  N   . ILE A 1 618 ? -7.66725  11.80333  17.53890  1.000 31.51880  ?  618  ILE A N   1 
ATOM   4700 C  CA  . ILE A 1 618 ? -8.72849  10.89465  17.11679  1.000 30.37947  ?  618  ILE A CA  1 
ATOM   4701 C  C   . ILE A 1 618 ? -9.73010  10.69141  18.24171  1.000 29.63694  ?  618  ILE A C   1 
ATOM   4702 O  O   . ILE A 1 618 ? -10.94121 10.69864  18.01157  1.000 33.33684  ?  618  ILE A O   1 
ATOM   4703 C  CB  . ILE A 1 618 ? -8.16376  9.55071   16.63655  1.000 30.57566  ?  618  ILE A CB  1 
ATOM   4704 C  CG1 . ILE A 1 618 ? -7.27566  9.72254   15.39891  1.000 35.02579  ?  618  ILE A CG1 1 
ATOM   4705 C  CG2 . ILE A 1 618 ? -9.33600  8.57709   16.40054  1.000 33.71348  ?  618  ILE A CG2 1 
ATOM   4706 C  CD1 . ILE A 1 618 ? -8.02929  10.14580  14.15514  1.000 38.20913  ?  618  ILE A CD1 1 
ATOM   4707 N  N   . THR A 1 619 ? -9.24679  10.50400  19.47687  1.000 28.08716  ?  619  THR A N   1 
ATOM   4708 C  CA  . THR A 1 619 ? -10.19164 10.29938  20.57326  1.000 32.27861  ?  619  THR A CA  1 
ATOM   4709 C  C   . THR A 1 619 ? -11.03775 11.54679  20.81166  1.000 31.16368  ?  619  THR A C   1 
ATOM   4710 O  O   . THR A 1 619 ? -12.23461 11.43631  21.08537  1.000 30.05108  ?  619  THR A O   1 
ATOM   4711 C  CB  . THR A 1 619 ? -9.46727  9.85875   21.85561  1.000 34.17045  ?  619  THR A CB  1 
ATOM   4712 O  OG1 . THR A 1 619 ? -8.90423  8.55982   21.65790  1.000 34.38336  ?  619  THR A OG1 1 
ATOM   4713 C  CG2 . THR A 1 619 ? -10.44567 9.74614   23.00206  1.000 31.41142  ?  619  THR A CG2 1 
ATOM   4714 N  N   . GLU A 1 620 ? -10.44038 12.74275  20.69547  1.000 32.42137  ?  620  GLU A N   1 
ATOM   4715 C  CA  . GLU A 1 620 ? -11.22824 13.96774  20.82705  1.000 32.50743  ?  620  GLU A CA  1 
ATOM   4716 C  C   . GLU A 1 620 ? -12.31667 14.02684  19.76516  1.000 32.83479  ?  620  GLU A C   1 
ATOM   4717 O  O   . GLU A 1 620 ? -13.47686 14.32966  20.06596  1.000 31.22438  ?  620  GLU A O   1 
ATOM   4718 C  CB  . GLU A 1 620 ? -10.34034 15.22652  20.71843  1.000 34.21148  ?  620  GLU A CB  1 
ATOM   4719 C  CG  . GLU A 1 620 ? -9.38128  15.50753  21.87384  1.000 32.97175  ?  620  GLU A CG  1 
ATOM   4720 C  CD  . GLU A 1 620 ? -10.08464 15.91375  23.15633  1.000 33.92935  ?  620  GLU A CD  1 
ATOM   4721 O  OE1 . GLU A 1 620 ? -11.31615 16.08807  23.13399  1.000 43.54247  ?  620  GLU A OE1 1 
ATOM   4722 O  OE2 . GLU A 1 620 ? -9.40834  16.03243  24.19952  1.000 39.53885  -1 620  GLU A OE2 1 
ATOM   4723 N  N   . GLU A 1 621 ? -11.96327 13.74072  18.50576  1.000 33.86582  ?  621  GLU A N   1 
ATOM   4724 C  CA  . GLU A 1 621 ? -12.97766 13.83178  17.45754  1.000 33.16738  ?  621  GLU A CA  1 
ATOM   4725 C  C   . GLU A 1 621 ? -14.07117 12.78771  17.69270  1.000 35.98009  ?  621  GLU A C   1 
ATOM   4726 O  O   . GLU A 1 621 ? -15.25887 13.07753  17.49119  1.000 33.82065  ?  621  GLU A O   1 
ATOM   4727 C  CB  . GLU A 1 621 ? -12.35354 13.73333  16.04088  1.000 35.48431  ?  621  GLU A CB  1 
ATOM   4728 C  CG  . GLU A 1 621 ? -11.60243 12.42958  15.68026  1.000 38.41937  ?  621  GLU A CG  1 
ATOM   4729 C  CD  . GLU A 1 621 ? -11.47964 12.13883  14.13720  1.000 46.90095  ?  621  GLU A CD  1 
ATOM   4730 O  OE1 . GLU A 1 621 ? -10.96094 12.97710  13.36304  1.000 50.45863  ?  621  GLU A OE1 1 
ATOM   4731 O  OE2 . GLU A 1 621 ? -11.90231 11.04976  13.68687  1.000 48.60211  -1 621  GLU A OE2 1 
ATOM   4732 N  N   . MET A 1 622 ? -13.71461 11.59538  18.19564  1.000 31.08313  ?  622  MET A N   1 
ATOM   4733 C  CA  . MET A 1 622 ? -14.76142 10.60270  18.45405  1.000 30.43027  ?  622  MET A CA  1 
ATOM   4734 C  C   . MET A 1 622 ? -15.67719 11.05994  19.58528  1.000 34.96152  ?  622  MET A C   1 
ATOM   4735 O  O   . MET A 1 622 ? -16.89673 10.84128  19.54863  1.000 32.40736  ?  622  MET A O   1 
ATOM   4736 C  CB  . MET A 1 622 ? -14.16611 9.23362   18.79565  1.000 32.04162  ?  622  MET A CB  1 
ATOM   4737 C  CG  . MET A 1 622 ? -13.55868 8.47616   17.59610  1.000 32.67066  ?  622  MET A CG  1 
ATOM   4738 S  SD  . MET A 1 622 ? -12.69519 6.97440   18.09315  1.000 32.37353  ?  622  MET A SD  1 
ATOM   4739 C  CE  . MET A 1 622 ? -14.18163 5.92623   18.34408  1.000 28.24422  ?  622  MET A CE  1 
ATOM   4740 N  N   . LEU A 1 623 ? -15.09677 11.67231  20.61144  1.000 32.77443  ?  623  LEU A N   1 
ATOM   4741 C  CA  . LEU A 1 623 ? -15.88937 12.21546  21.69945  1.000 35.29627  ?  623  LEU A CA  1 
ATOM   4742 C  C   . LEU A 1 623 ? -16.86184 13.26175  21.17449  1.000 36.49087  ?  623  LEU A C   1 
ATOM   4743 O  O   . LEU A 1 623 ? -18.06049 13.21590  21.47026  1.000 34.30232  ?  623  LEU A O   1 
ATOM   4744 C  CB  . LEU A 1 623 ? -14.94990 12.80273  22.75432  1.000 37.04430  ?  623  LEU A CB  1 
ATOM   4745 C  CG  . LEU A 1 623 ? -15.50425 13.33098  24.07582  1.000 39.62693  ?  623  LEU A CG  1 
ATOM   4746 C  CD1 . LEU A 1 623 ? -16.52253 12.37817  24.65065  1.000 38.99696  ?  623  LEU A CD1 1 
ATOM   4747 C  CD2 . LEU A 1 623 ? -14.33772 13.46485  25.01214  1.000 39.62464  ?  623  LEU A CD2 1 
ATOM   4748 N  N   . LYS A 1 624 ? -16.36919 14.16704  20.32360  1.000 35.84833  ?  624  LYS A N   1 
ATOM   4749 C  CA  . LYS A 1 624 ? -17.22961 15.16180  19.69951  1.000 36.84847  ?  624  LYS A CA  1 
ATOM   4750 C  C   . LYS A 1 624 ? -18.26185 14.54102  18.75849  1.000 32.74660  ?  624  LYS A C   1 
ATOM   4751 O  O   . LYS A 1 624 ? -19.27061 15.18232  18.46264  1.000 35.39383  ?  624  LYS A O   1 
ATOM   4752 C  CB  . LYS A 1 624 ? -16.37546 16.19274  18.95407  1.000 39.11741  ?  624  LYS A CB  1 
ATOM   4753 C  CG  . LYS A 1 624 ? -15.42036 16.99937  19.84657  1.000 41.18672  ?  624  LYS A CG  1 
ATOM   4754 C  CD  . LYS A 1 624 ? -14.48907 17.90511  18.99274  1.000 36.53636  ?  624  LYS A CD  1 
ATOM   4755 C  CE  . LYS A 1 624 ? -14.84593 19.35527  19.13760  1.000 47.00953  ?  624  LYS A CE  1 
ATOM   4756 N  NZ  . LYS A 1 624 ? -16.03781 19.73522  18.32476  1.000 48.50054  ?  624  LYS A NZ  1 
ATOM   4757 N  N   . ALA A 1 625 ? -18.06639 13.30682  18.30887  1.000 36.45544  ?  625  ALA A N   1 
ATOM   4758 C  CA  . ALA A 1 625 ? -19.06391 12.63260  17.47639  1.000 34.27759  ?  625  ALA A CA  1 
ATOM   4759 C  C   . ALA A 1 625 ? -20.01050 11.74816  18.29038  1.000 32.97515  ?  625  ALA A C   1 
ATOM   4760 O  O   . ALA A 1 625 ? -20.81401 11.02527  17.70910  1.000 28.92745  ?  625  ALA A O   1 
ATOM   4761 C  CB  . ALA A 1 625 ? -18.37147 11.80276  16.38716  1.000 28.76441  ?  625  ALA A CB  1 
ATOM   4762 N  N   . GLY A 1 626 ? -19.90785 11.78083  19.61644  1.000 33.39565  ?  626  GLY A N   1 
ATOM   4763 C  CA  . GLY A 1 626 ? -20.75563 10.99055  20.49261  1.000 27.98710  ?  626  GLY A CA  1 
ATOM   4764 C  C   . GLY A 1 626 ? -20.57840 9.49512   20.34455  1.000 33.03309  ?  626  GLY A C   1 
ATOM   4765 O  O   . GLY A 1 626 ? -21.55151 8.75129   20.47491  1.000 35.96047  ?  626  GLY A O   1 
ATOM   4766 N  N   . LEU A 1 627 ? -19.36094 9.03318   20.06508  1.000 32.96985  ?  627  LEU A N   1 
ATOM   4767 C  CA  . LEU A 1 627 ? -19.09963 7.62423   19.80202  1.000 33.96288  ?  627  LEU A CA  1 
ATOM   4768 C  C   . LEU A 1 627 ? -18.49340 6.91290   20.98831  1.000 36.48508  ?  627  LEU A C   1 
ATOM   4769 O  O   . LEU A 1 627 ? -18.08486 5.76347   20.84920  1.000 35.55517  ?  627  LEU A O   1 
ATOM   4770 C  CB  . LEU A 1 627 ? -18.16664 7.45744   18.59624  1.000 33.37706  ?  627  LEU A CB  1 
ATOM   4771 C  CG  . LEU A 1 627 ? -18.53221 8.14075   17.26790  1.000 36.02559  ?  627  LEU A CG  1 
ATOM   4772 C  CD1 . LEU A 1 627 ? -17.39024 8.00265   16.24658  1.000 32.51368  ?  627  LEU A CD1 1 
ATOM   4773 C  CD2 . LEU A 1 627 ? -19.82640 7.55830   16.70198  1.000 35.32980  ?  627  LEU A CD2 1 
ATOM   4774 N  N   . LEU A 1 628 ? -18.39871 7.57069   22.14837  1.000 37.37091  ?  628  LEU A N   1 
ATOM   4775 C  CA  . LEU A 1 628 ? -17.65511 7.02845   23.27513  1.000 33.98804  ?  628  LEU A CA  1 
ATOM   4776 C  C   . LEU A 1 628 ? -18.51874 6.86879   24.52325  1.000 37.92512  ?  628  LEU A C   1 
ATOM   4777 O  O   . LEU A 1 628 ? -18.02253 7.01267   25.64360  1.000 36.21678  ?  628  LEU A O   1 
ATOM   4778 C  CB  . LEU A 1 628 ? -16.43355 7.89164   23.58309  1.000 32.41966  ?  628  LEU A CB  1 
ATOM   4779 C  CG  . LEU A 1 628 ? -15.30500 7.90803   22.56483  1.000 38.47759  ?  628  LEU A CG  1 
ATOM   4780 C  CD1 . LEU A 1 628 ? -14.12050 8.75528   23.07746  1.000 34.58382  ?  628  LEU A CD1 1 
ATOM   4781 C  CD2 . LEU A 1 628 ? -14.86186 6.49099   22.24379  1.000 32.52023  ?  628  LEU A CD2 1 
ATOM   4782 N  N   . ASP A 1 629 ? -19.81057 6.57236   24.35632  1.000 39.51190  ?  629  ASP A N   1 
ATOM   4783 C  CA  . ASP A 1 629 ? -20.60969 6.22119   25.52541  1.000 42.41115  ?  629  ASP A CA  1 
ATOM   4784 C  C   . ASP A 1 629 ? -20.16402 4.88951   26.12926  1.000 43.91835  ?  629  ASP A C   1 
ATOM   4785 O  O   . ASP A 1 629 ? -20.25725 4.70513   27.34427  1.000 44.68029  ?  629  ASP A O   1 
ATOM   4786 C  CB  . ASP A 1 629 ? -22.09484 6.17628   25.17346  1.000 45.27569  ?  629  ASP A CB  1 
ATOM   4787 C  CG  . ASP A 1 629 ? -22.64147 7.53411   24.76209  1.000 53.70014  ?  629  ASP A CG  1 
ATOM   4788 O  OD1 . ASP A 1 629 ? -21.97293 8.56974   25.01633  1.000 56.10474  ?  629  ASP A OD1 1 
ATOM   4789 O  OD2 . ASP A 1 629 ? -23.74175 7.56586   24.17639  1.000 57.23006  -1 629  ASP A OD2 1 
ATOM   4790 N  N   . ASP A 1 630 ? -19.67949 3.95309   25.31107  1.000 45.88793  ?  630  ASP A N   1 
ATOM   4791 C  CA  . ASP A 1 630 ? -19.05371 2.71941   25.79823  1.000 39.79156  ?  630  ASP A CA  1 
ATOM   4792 C  C   . ASP A 1 630 ? -17.69261 2.58256   25.12384  1.000 39.69859  ?  630  ASP A C   1 
ATOM   4793 O  O   . ASP A 1 630 ? -17.57100 1.96064   24.05992  1.000 37.00823  ?  630  ASP A O   1 
ATOM   4794 C  CB  . ASP A 1 630 ? -19.94577 1.50538   25.55140  1.000 42.05736  ?  630  ASP A CB  1 
ATOM   4795 C  CG  . ASP A 1 630 ? -19.31462 0.19887   26.04853  1.000 53.92297  ?  630  ASP A CG  1 
ATOM   4796 O  OD1 . ASP A 1 630 ? -18.23475 0.25076   26.69491  1.000 50.57262  ?  630  ASP A OD1 1 
ATOM   4797 O  OD2 . ASP A 1 630 ? -19.92180 -0.87895  25.81566  1.000 57.19478  -1 630  ASP A OD2 1 
ATOM   4798 N  N   . PRO A 1 631 ? -16.63826 3.13468   25.73614  1.000 34.72154  ?  631  PRO A N   1 
ATOM   4799 C  CA  . PRO A 1 631 ? -15.36691 3.31685   25.01348  1.000 37.62519  ?  631  PRO A CA  1 
ATOM   4800 C  C   . PRO A 1 631 ? -14.63867 2.03262   24.64652  1.000 35.24762  ?  631  PRO A C   1 
ATOM   4801 O  O   . PRO A 1 631 ? -13.76891 2.08224   23.78030  1.000 35.76678  ?  631  PRO A O   1 
ATOM   4802 C  CB  . PRO A 1 631 ? -14.52813 4.16673   25.98087  1.000 37.08539  ?  631  PRO A CB  1 
ATOM   4803 C  CG  . PRO A 1 631 ? -15.52483 4.77246   26.92410  1.000 37.02241  ?  631  PRO A CG  1 
ATOM   4804 C  CD  . PRO A 1 631 ? -16.61057 3.76156   27.06384  1.000 36.99301  ?  631  PRO A CD  1 
ATOM   4805 N  N   . LEU A 1 632 ? -14.93044 0.89801   25.26949  1.000 39.95018  ?  632  LEU A N   1 
ATOM   4806 C  CA  . LEU A 1 632 ? -14.29057 -0.35466  24.88690  1.000 40.54901  ?  632  LEU A CA  1 
ATOM   4807 C  C   . LEU A 1 632 ? -15.17333 -1.21997  23.98223  1.000 41.77876  ?  632  LEU A C   1 
ATOM   4808 O  O   . LEU A 1 632 ? -14.85031 -2.39021  23.75594  1.000 38.46797  ?  632  LEU A O   1 
ATOM   4809 C  CB  . LEU A 1 632 ? -13.88530 -1.13036  26.14233  1.000 40.41872  ?  632  LEU A CB  1 
ATOM   4810 C  CG  . LEU A 1 632 ? -12.91879 -0.42612  27.11518  1.000 40.61851  ?  632  LEU A CG  1 
ATOM   4811 C  CD1 . LEU A 1 632 ? -12.60650 -1.30265  28.35795  1.000 43.63389  ?  632  LEU A CD1 1 
ATOM   4812 C  CD2 . LEU A 1 632 ? -11.64762 -0.03669  26.42280  1.000 36.42510  ?  632  LEU A CD2 1 
ATOM   4813 N  N   . SER A 1 633 ? -16.27723 -0.67259  23.46492  1.000 37.57844  ?  633  SER A N   1 
ATOM   4814 C  CA  . SER A 1 633 ? -17.21143 -1.44030  22.64407  1.000 36.89521  ?  633  SER A CA  1 
ATOM   4815 C  C   . SER A 1 633 ? -16.60125 -1.77256  21.27944  1.000 39.00736  ?  633  SER A C   1 
ATOM   4816 O  O   . SER A 1 633 ? -15.68771 -1.08693  20.80983  1.000 33.90723  ?  633  SER A O   1 
ATOM   4817 C  CB  . SER A 1 633 ? -18.51100 -0.65384  22.43931  1.000 39.37024  ?  633  SER A CB  1 
ATOM   4818 O  OG  . SER A 1 633 ? -18.28472 0.53038   21.66130  1.000 40.37225  ?  633  SER A OG  1 
ATOM   4819 N  N   . PRO A 1 634 ? -17.10544 -2.82166  20.61235  1.000 34.00407  ?  634  PRO A N   1 
ATOM   4820 C  CA  . PRO A 1 634 ? -16.67162 -3.08374  19.22240  1.000 32.51739  ?  634  PRO A CA  1 
ATOM   4821 C  C   . PRO A 1 634 ? -16.82370 -1.88025  18.28609  1.000 37.75962  ?  634  PRO A C   1 
ATOM   4822 O  O   . PRO A 1 634 ? -15.92692 -1.60985  17.47307  1.000 34.33487  ?  634  PRO A O   1 
ATOM   4823 C  CB  . PRO A 1 634 ? -17.57500 -4.25501  18.79779  1.000 40.78341  ?  634  PRO A CB  1 
ATOM   4824 C  CG  . PRO A 1 634 ? -17.91490 -4.95980  20.07018  1.000 43.28288  ?  634  PRO A CG  1 
ATOM   4825 C  CD  . PRO A 1 634 ? -18.04237 -3.84368  21.11197  1.000 37.54246  ?  634  PRO A CD  1 
ATOM   4826 N  N   . LEU A 1 635 ? -17.92839 -1.13463  18.40190  1.000 33.15599  ?  635  LEU A N   1 
ATOM   4827 C  CA  . LEU A 1 635 ? -18.12543 0.04470   17.57026  1.000 36.82542  ?  635  LEU A CA  1 
ATOM   4828 C  C   . LEU A 1 635 ? -17.02400 1.07282   17.81955  1.000 33.87679  ?  635  LEU A C   1 
ATOM   4829 O  O   . LEU A 1 635 ? -16.46453 1.64575   16.88078  1.000 34.39479  ?  635  LEU A O   1 
ATOM   4830 C  CB  . LEU A 1 635 ? -19.49568 0.66938   17.86125  1.000 36.22729  ?  635  LEU A CB  1 
ATOM   4831 C  CG  . LEU A 1 635 ? -20.81128 0.16357   17.26919  1.000 48.80308  ?  635  LEU A CG  1 
ATOM   4832 C  CD1 . LEU A 1 635 ? -20.72897 -0.09611  15.76052  1.000 47.94636  ?  635  LEU A CD1 1 
ATOM   4833 C  CD2 . LEU A 1 635 ? -21.29251 -1.07796  18.01759  1.000 60.51512  ?  635  LEU A CD2 1 
ATOM   4834 N  N   . ALA A 1 636 ? -16.70665 1.31583   19.09151  1.000 30.35628  ?  636  ALA A N   1 
ATOM   4835 C  CA  . ALA A 1 636 ? -15.70564 2.31635   19.43739  1.000 39.74153  ?  636  ALA A CA  1 
ATOM   4836 C  C   . ALA A 1 636 ? -14.34354 1.94188   18.86323  1.000 36.38415  ?  636  ALA A C   1 
ATOM   4837 O  O   . ALA A 1 636 ? -13.68305 2.77421   18.23195  1.000 32.17307  ?  636  ALA A O   1 
ATOM   4838 C  CB  . ALA A 1 636 ? -15.64006 2.48918   20.96384  1.000 33.84692  ?  636  ALA A CB  1 
ATOM   4839 N  N   . PHE A 1 637 ? -13.92982 0.67668   19.03332  1.000 32.10812  ?  637  PHE A N   1 
ATOM   4840 C  CA  . PHE A 1 637 ? -12.61292 0.26224   18.55492  1.000 35.37981  ?  637  PHE A CA  1 
ATOM   4841 C  C   . PHE A 1 637 ? -12.52727 0.30444   17.03215  1.000 35.96652  ?  637  PHE A C   1 
ATOM   4842 O  O   . PHE A 1 637 ? -11.52196 0.78282   16.47360  1.000 34.59351  ?  637  PHE A O   1 
ATOM   4843 C  CB  . PHE A 1 637 ? -12.26686 -1.13650  19.06879  1.000 37.96413  ?  637  PHE A CB  1 
ATOM   4844 C  CG  . PHE A 1 637 ? -11.75466 -1.15314  20.48934  1.000 44.43863  ?  637  PHE A CG  1 
ATOM   4845 C  CD1 . PHE A 1 637 ? -11.34433 0.00683   21.10707  1.000 42.21652  ?  637  PHE A CD1 1 
ATOM   4846 C  CD2 . PHE A 1 637 ? -11.67326 -2.33316  21.20379  1.000 41.70278  ?  637  PHE A CD2 1 
ATOM   4847 C  CE1 . PHE A 1 637 ? -10.86885 -0.00197  22.42113  1.000 41.83347  ?  637  PHE A CE1 1 
ATOM   4848 C  CE2 . PHE A 1 637 ? -11.19445 -2.34221  22.52259  1.000 44.46877  ?  637  PHE A CE2 1 
ATOM   4849 C  CZ  . PHE A 1 637 ? -10.78271 -1.17104  23.12172  1.000 36.43693  ?  637  PHE A CZ  1 
ATOM   4850 N  N   . ALA A 1 638 ? -13.56677 -0.18607  16.33940  1.000 35.56242  ?  638  ALA A N   1 
ATOM   4851 C  CA  . ALA A 1 638 ? -13.52856 -0.13707  14.87602  1.000 36.55768  ?  638  ALA A CA  1 
ATOM   4852 C  C   . ALA A 1 638 ? -13.43981 1.30534   14.37861  1.000 36.77876  ?  638  ALA A C   1 
ATOM   4853 O  O   . ALA A 1 638 ? -12.65543 1.61711   13.46425  1.000 38.15927  ?  638  ALA A O   1 
ATOM   4854 C  CB  . ALA A 1 638 ? -14.75682 -0.82599  14.28643  1.000 32.67088  ?  638  ALA A CB  1 
ATOM   4855 N  N   . GLU A 1 639 ? -14.21826 2.20794   14.98711  1.000 35.86753  ?  639  GLU A N   1 
ATOM   4856 C  CA  . GLU A 1 639 ? -14.17505 3.60178   14.56850  1.000 34.92702  ?  639  GLU A CA  1 
ATOM   4857 C  C   . GLU A 1 639 ? -12.80616 4.22718   14.85364  1.000 36.49098  ?  639  GLU A C   1 
ATOM   4858 O  O   . GLU A 1 639 ? -12.28418 5.00241   14.03299  1.000 32.30308  ?  639  GLU A O   1 
ATOM   4859 C  CB  . GLU A 1 639 ? -15.30685 4.37431   15.25308  1.000 33.68830  ?  639  GLU A CB  1 
ATOM   4860 C  CG  . GLU A 1 639 ? -16.60628 4.38612   14.48183  1.000 41.23447  ?  639  GLU A CG  1 
ATOM   4861 C  CD  . GLU A 1 639 ? -16.45587 5.07653   13.10682  1.000 49.54552  ?  639  GLU A CD  1 
ATOM   4862 O  OE1 . GLU A 1 639 ? -16.61110 4.38932   12.07138  1.000 40.28413  ?  639  GLU A OE1 1 
ATOM   4863 O  OE2 . GLU A 1 639 ? -16.17763 6.30261   13.07158  1.000 48.70477  -1 639  GLU A OE2 1 
ATOM   4864 N  N   . TYR A 1 640 ? -12.20330 3.90275   16.00682  1.000 33.16550  ?  640  TYR A N   1 
ATOM   4865 C  CA  . TYR A 1 640 ? -10.89359 4.46423   16.31964  1.000 29.77786  ?  640  TYR A CA  1 
ATOM   4866 C  C   . TYR A 1 640 ? -9.84725  4.04257   15.28514  1.000 34.91056  ?  640  TYR A C   1 
ATOM   4867 O  O   . TYR A 1 640 ? -9.05984  4.87368   14.80657  1.000 29.65510  ?  640  TYR A O   1 
ATOM   4868 C  CB  . TYR A 1 640 ? -10.44271 4.06141   17.72784  1.000 28.73799  ?  640  TYR A CB  1 
ATOM   4869 C  CG  . TYR A 1 640 ? -9.05492  4.57121   18.02145  1.000 29.07919  ?  640  TYR A CG  1 
ATOM   4870 C  CD1 . TYR A 1 640 ? -8.84386  5.89290   18.43155  1.000 29.29623  ?  640  TYR A CD1 1 
ATOM   4871 C  CD2 . TYR A 1 640 ? -7.93497  3.75245   17.83434  1.000 32.32796  ?  640  TYR A CD2 1 
ATOM   4872 C  CE1 . TYR A 1 640 ? -7.56621  6.36897   18.65965  1.000 26.66252  ?  640  TYR A CE1 1 
ATOM   4873 C  CE2 . TYR A 1 640 ? -6.66444  4.21609   18.05408  1.000 25.19663  ?  640  TYR A CE2 1 
ATOM   4874 C  CZ  . TYR A 1 640 ? -6.47516  5.51661   18.46920  1.000 30.58552  ?  640  TYR A CZ  1 
ATOM   4875 O  OH  . TYR A 1 640 ? -5.18479  5.95922   18.69632  1.000 31.33120  ?  640  TYR A OH  1 
ATOM   4876 N  N   . PHE A 1 641 ? -9.81957  2.75322   14.92101  1.000 32.18352  ?  641  PHE A N   1 
ATOM   4877 C  CA  . PHE A 1 641 ? -8.77990  2.33070   13.98370  1.000 35.61093  ?  641  PHE A CA  1 
ATOM   4878 C  C   . PHE A 1 641 ? -9.04448  2.86545   12.57003  1.000 36.28682  ?  641  PHE A C   1 
ATOM   4879 O  O   . PHE A 1 641 ? -8.10106  3.24690   11.86273  1.000 34.39204  ?  641  PHE A O   1 
ATOM   4880 C  CB  . PHE A 1 641 ? -8.62242  0.80654   13.99218  1.000 35.13395  ?  641  PHE A CB  1 
ATOM   4881 C  CG  . PHE A 1 641 ? -7.84805  0.28170   15.19061  1.000 34.61066  ?  641  PHE A CG  1 
ATOM   4882 C  CD1 . PHE A 1 641 ? -6.46411  0.24709   15.18571  1.000 42.61711  ?  641  PHE A CD1 1 
ATOM   4883 C  CD2 . PHE A 1 641 ? -8.51498  -0.16532  16.32640  1.000 39.02785  ?  641  PHE A CD2 1 
ATOM   4884 C  CE1 . PHE A 1 641 ? -5.74382  -0.22855  16.29511  1.000 40.04329  ?  641  PHE A CE1 1 
ATOM   4885 C  CE2 . PHE A 1 641 ? -7.81753  -0.63576  17.43724  1.000 36.61778  ?  641  PHE A CE2 1 
ATOM   4886 C  CZ  . PHE A 1 641 ? -6.41980  -0.66898  17.42282  1.000 33.90921  ?  641  PHE A CZ  1 
ATOM   4887 N  N   . ARG A 1 642 ? -10.31206 2.93967   12.14315  1.000 36.71707  ?  642  ARG A N   1 
ATOM   4888 C  CA  . ARG A 1 642 ? -10.59001 3.52266   10.82639  1.000 31.43412  ?  642  ARG A CA  1 
ATOM   4889 C  C   . ARG A 1 642 ? -10.16975 4.99738   10.76769  1.000 38.66748  ?  642  ARG A C   1 
ATOM   4890 O  O   . ARG A 1 642 ? -9.58219  5.45027   9.77913   1.000 37.05733  ?  642  ARG A O   1 
ATOM   4891 C  CB  . ARG A 1 642 ? -12.07515 3.37652   10.49026  1.000 38.33338  ?  642  ARG A CB  1 
ATOM   4892 C  CG  . ARG A 1 642 ? -12.58789 4.34988   9.40096   1.000 36.17186  ?  642  ARG A CG  1 
ATOM   4893 C  CD  . ARG A 1 642 ? -14.10059 4.33137   9.29648   1.000 36.57169  ?  642  ARG A CD  1 
ATOM   4894 N  NE  . ARG A 1 642 ? -14.76333 5.37135   10.07699  1.000 41.20131  ?  642  ARG A NE  1 
ATOM   4895 C  CZ  . ARG A 1 642 ? -14.59903 6.68015   9.90489   1.000 42.20584  ?  642  ARG A CZ  1 
ATOM   4896 N  NH1 . ARG A 1 642 ? -13.72264 7.16518   9.03059   1.000 39.78798  ?  642  ARG A NH1 1 
ATOM   4897 N  NH2 . ARG A 1 642 ? -15.34697 7.52546   10.61430  1.000 38.59301  ?  642  ARG A NH2 1 
ATOM   4898 N  N   . ARG A 1 643 ? -10.46635 5.76747   11.81246  1.000 32.95165  ?  643  ARG A N   1 
ATOM   4899 C  CA  . ARG A 1 643 ? -10.08941 7.17921   11.78558  1.000 36.10677  ?  643  ARG A CA  1 
ATOM   4900 C  C   . ARG A 1 643 ? -8.57719  7.35174   11.84626  1.000 38.55906  ?  643  ARG A C   1 
ATOM   4901 O  O   . ARG A 1 643 ? -8.00847  8.16784   11.10841  1.000 35.36186  ?  643  ARG A O   1 
ATOM   4902 C  CB  . ARG A 1 643 ? -10.76283 7.90856   12.93742  1.000 32.06260  ?  643  ARG A CB  1 
ATOM   4903 C  CG  . ARG A 1 643 ? -12.25182 7.98303   12.76274  1.000 34.29767  ?  643  ARG A CG  1 
ATOM   4904 C  CD  . ARG A 1 643 ? -12.95805 8.33115   14.06041  1.000 34.62986  ?  643  ARG A CD  1 
ATOM   4905 N  NE  . ARG A 1 643 ? -14.39801 8.38324   13.84740  1.000 41.78382  ?  643  ARG A NE  1 
ATOM   4906 C  CZ  . ARG A 1 643 ? -15.08771 9.49514   13.64196  1.000 42.04319  ?  643  ARG A CZ  1 
ATOM   4907 N  NH1 . ARG A 1 643 ? -14.51034 10.68161  13.68319  1.000 35.93671  ?  643  ARG A NH1 1 
ATOM   4908 N  NH2 . ARG A 1 643 ? -16.39088 9.41059   13.38331  1.000 47.49033  ?  643  ARG A NH2 1 
ATOM   4909 N  N   . PHE A 1 644 ? -7.90981  6.56451   12.70271  1.000 40.22885  ?  644  PHE A N   1 
ATOM   4910 C  CA  . PHE A 1 644 ? -6.46232  6.63352   12.81679  1.000 37.89496  ?  644  PHE A CA  1 
ATOM   4911 C  C   . PHE A 1 644 ? -5.79094  6.29166   11.49699  1.000 38.44954  ?  644  PHE A C   1 
ATOM   4912 O  O   . PHE A 1 644 ? -4.84053  6.96156   11.07647  1.000 38.08456  ?  644  PHE A O   1 
ATOM   4913 C  CB  . PHE A 1 644 ? -5.97909  5.68295   13.91189  1.000 35.04118  ?  644  PHE A CB  1 
ATOM   4914 C  CG  . PHE A 1 644 ? -4.58291  5.97219   14.36331  1.000 40.14068  ?  644  PHE A CG  1 
ATOM   4915 C  CD1 . PHE A 1 644 ? -4.34480  6.88254   15.38281  1.000 36.55098  ?  644  PHE A CD1 1 
ATOM   4916 C  CD2 . PHE A 1 644 ? -3.49730  5.36827   13.73304  1.000 41.86706  ?  644  PHE A CD2 1 
ATOM   4917 C  CE1 . PHE A 1 644 ? -3.03697  7.16820   15.79358  1.000 38.78361  ?  644  PHE A CE1 1 
ATOM   4918 C  CE2 . PHE A 1 644 ? -2.20122  5.65357   14.12744  1.000 37.90461  ?  644  PHE A CE2 1 
ATOM   4919 C  CZ  . PHE A 1 644 ? -1.97066  6.54380   15.16365  1.000 40.33207  ?  644  PHE A CZ  1 
ATOM   4920 N  N   . ASN A 1 645 ? -6.25354  5.22770   10.84475  1.000 37.97346  ?  645  ASN A N   1 
ATOM   4921 C  CA  . ASN A 1 645 ? -5.68451  4.82810   9.56701   1.000 43.68249  ?  645  ASN A CA  1 
ATOM   4922 C  C   . ASN A 1 645 ? -6.08692  5.77870   8.44728   1.000 41.36339  ?  645  ASN A C   1 
ATOM   4923 O  O   . ASN A 1 645 ? -5.49294  5.72846   7.37211   1.000 39.60579  ?  645  ASN A O   1 
ATOM   4924 C  CB  . ASN A 1 645 ? -6.09577  3.38742   9.24109   1.000 42.63067  ?  645  ASN A CB  1 
ATOM   4925 C  CG  . ASN A 1 645 ? -5.46603  2.36232   10.19768  1.000 43.35900  ?  645  ASN A CG  1 
ATOM   4926 O  OD1 . ASN A 1 645 ? -4.52104  2.67124   10.91355  1.000 43.44843  ?  645  ASN A OD1 1 
ATOM   4927 N  ND2 . ASN A 1 645 ? -5.98758  1.14158   10.19660  1.000 40.77267  ?  645  ASN A ND2 1 
ATOM   4928 N  N   . GLY A 1 646 ? -7.06141  6.65211   8.67628   1.000 40.06487  ?  646  GLY A N   1 
ATOM   4929 C  CA  . GLY A 1 646 ? -7.32811  7.66611   7.68465   1.000 39.13981  ?  646  GLY A CA  1 
ATOM   4930 C  C   . GLY A 1 646 ? -6.49252  8.91936   7.80559   1.000 39.21157  ?  646  GLY A C   1 
ATOM   4931 O  O   . GLY A 1 646 ? -6.69817  9.84880   7.02867   1.000 42.27886  ?  646  GLY A O   1 
ATOM   4932 N  N   . LYS A 1 647 ? -5.53725  8.97985   8.73833   1.000 43.88937  ?  647  LYS A N   1 
ATOM   4933 C  CA  . LYS A 1 647 ? -4.91365  10.23677  9.14208   1.000 40.55452  ?  647  LYS A CA  1 
ATOM   4934 C  C   . LYS A 1 647 ? -3.39203  10.12246  9.21088   1.000 47.63289  ?  647  LYS A C   1 
ATOM   4935 O  O   . LYS A 1 647 ? -2.84973  9.08669   9.62491   1.000 38.30463  ?  647  LYS A O   1 
ATOM   4936 C  CB  . LYS A 1 647 ? -5.45504  10.65724  10.51213  1.000 42.50258  ?  647  LYS A CB  1 
ATOM   4937 C  CG  . LYS A 1 647 ? -5.58021  12.15310  10.71065  1.000 48.48574  ?  647  LYS A CG  1 
ATOM   4938 C  CD  . LYS A 1 647 ? -6.70712  12.48391  11.68591  1.000 47.54913  ?  647  LYS A CD  1 
ATOM   4939 C  CE  . LYS A 1 647 ? -8.08787  12.41309  11.03380  1.000 50.80216  ?  647  LYS A CE  1 
ATOM   4940 N  NZ  . LYS A 1 647 ? -8.41719  13.69847  10.36665  1.000 64.26821  ?  647  LYS A NZ  1 
ATOM   4941 N  N   . GLY A 1 648 ? -2.70826  11.20068  8.84487   1.000 44.53304  ?  648  GLY A N   1 
ATOM   4942 C  CA  . GLY A 1 648 ? -1.26535  11.25003  8.97513   1.000 39.67557  ?  648  GLY A CA  1 
ATOM   4943 C  C   . GLY A 1 648 ? -0.53716  10.89935  7.68680   1.000 41.72043  ?  648  GLY A C   1 
ATOM   4944 O  O   . GLY A 1 648 ? -1.02444  10.13848  6.84838   1.000 45.86106  ?  648  GLY A O   1 
ATOM   4945 N  N   . ASP A 1 649 ? 0.65494   11.47333  7.52484   1.000 45.83409  ?  649  ASP A N   1 
ATOM   4946 C  CA  . ASP A 1 649 ? 1.51307   11.21188  6.37570   1.000 45.14669  ?  649  ASP A CA  1 
ATOM   4947 C  C   . ASP A 1 649 ? 2.39267   10.00582  6.68778   1.000 42.02081  ?  649  ASP A C   1 
ATOM   4948 O  O   . ASP A 1 649 ? 3.21426   10.05299  7.60630   1.000 46.71486  ?  649  ASP A O   1 
ATOM   4949 C  CB  . ASP A 1 649 ? 2.35868   12.44327  6.05476   1.000 47.62207  ?  649  ASP A CB  1 
ATOM   4950 C  CG  . ASP A 1 649 ? 3.30795   12.22869  4.88156   1.000 46.30796  ?  649  ASP A CG  1 
ATOM   4951 O  OD1 . ASP A 1 649 ? 3.26503   11.16050  4.23604   1.000 45.77901  ?  649  ASP A OD1 1 
ATOM   4952 O  OD2 . ASP A 1 649 ? 4.11222   13.14875  4.59798   1.000 55.11632  -1 649  ASP A OD2 1 
ATOM   4953 N  N   . VAL A 1 650 ? 2.22403   8.92649   5.92362   1.000 43.61240  ?  650  VAL A N   1 
ATOM   4954 C  CA  . VAL A 1 650 ? 2.85290   7.66261   6.30165   1.000 39.96419  ?  650  VAL A CA  1 
ATOM   4955 C  C   . VAL A 1 650 ? 4.32856   7.57323   5.92783   1.000 40.26725  ?  650  VAL A C   1 
ATOM   4956 O  O   . VAL A 1 650 ? 5.02432   6.68300   6.43476   1.000 37.53887  ?  650  VAL A O   1 
ATOM   4957 C  CB  . VAL A 1 650 ? 2.09496   6.48356   5.68038   1.000 43.11464  ?  650  VAL A CB  1 
ATOM   4958 C  CG1 . VAL A 1 650 ? 0.66479   6.46484   6.18343   1.000 48.34854  ?  650  VAL A CG1 1 
ATOM   4959 C  CG2 . VAL A 1 650 ? 2.12693   6.59986   4.16249   1.000 38.41060  ?  650  VAL A CG2 1 
ATOM   4960 N  N   . ASP A 1 651 ? 4.83811   8.43902   5.03761   1.000 38.52156  ?  651  ASP A N   1 
ATOM   4961 C  CA  . ASP A 1 651 ? 6.28487   8.59713   4.87746   1.000 32.99638  ?  651  ASP A CA  1 
ATOM   4962 C  C   . ASP A 1 651 ? 6.58884   10.08514  4.90220   1.000 34.48831  ?  651  ASP A C   1 
ATOM   4963 O  O   . ASP A 1 651 ? 6.94747   10.65349  3.87321   1.000 34.01386  ?  651  ASP A O   1 
ATOM   4964 C  CB  . ASP A 1 651 ? 6.77473   7.97163   3.60025   1.000 30.14442  ?  651  ASP A CB  1 
ATOM   4965 C  CG  . ASP A 1 651 ? 8.29962   7.76162   3.58435   1.000 33.03395  ?  651  ASP A CG  1 
ATOM   4966 O  OD1 . ASP A 1 651 ? 8.98502   8.02907   4.60186   1.000 31.96393  -1 651  ASP A OD1 1 
ATOM   4967 O  OD2 . ASP A 1 651 ? 8.81943   7.31513   2.54923   1.000 38.25147  -1 651  ASP A OD2 1 
ATOM   4968 N  N   . LYS A 1 652 ? 6.59751   10.66419  6.09810   1.000 38.65508  ?  652  LYS A N   1 
ATOM   4969 C  CA  . LYS A 1 652 ? 6.77347   12.10638  6.22073   1.000 41.13949  ?  652  LYS A CA  1 
ATOM   4970 C  C   . LYS A 1 652 ? 8.18661   12.53526  5.87215   1.000 39.19987  ?  652  LYS A C   1 
ATOM   4971 O  O   . LYS A 1 652 ? 8.39845   13.65915  5.42278   1.000 41.73743  ?  652  LYS A O   1 
ATOM   4972 C  CB  . LYS A 1 652 ? 6.43797   12.55561  7.63911   1.000 44.22829  ?  652  LYS A CB  1 
ATOM   4973 C  CG  . LYS A 1 652 ? 6.04675   14.02350  7.75112   1.000 45.42804  ?  652  LYS A CG  1 
ATOM   4974 C  CD  . LYS A 1 652 ? 5.86416   14.42917  9.21082   1.000 50.62258  ?  652  LYS A CD  1 
ATOM   4975 C  CE  . LYS A 1 652 ? 4.78150   15.50386  9.37472   1.000 62.37895  ?  652  LYS A CE  1 
ATOM   4976 N  NZ  . LYS A 1 652 ? 3.39532   14.91984  9.45729   1.000 63.15560  ?  652  LYS A NZ  1 
ATOM   4977 N  N   . HIS A 1 653 ? 9.16519   11.66211  6.05856   1.000 43.90502  ?  653  HIS A N   1 
ATOM   4978 C  CA  . HIS A 1 653 ? 10.54850  12.06771  5.89649   1.000 43.22841  ?  653  HIS A CA  1 
ATOM   4979 C  C   . HIS A 1 653 ? 11.18315  11.53396  4.62335   1.000 38.93630  ?  653  HIS A C   1 
ATOM   4980 O  O   . HIS A 1 653 ? 12.40272  11.62230  4.48229   1.000 45.16015  ?  653  HIS A O   1 
ATOM   4981 C  CB  . HIS A 1 653 ? 11.32939  11.65451  7.13793   1.000 41.05163  ?  653  HIS A CB  1 
ATOM   4982 C  CG  . HIS A 1 653 ? 10.68932  12.13738  8.39795   1.000 47.97805  ?  653  HIS A CG  1 
ATOM   4983 N  ND1 . HIS A 1 653 ? 10.71473  13.46370  8.77999   1.000 47.67975  ?  653  HIS A ND1 1 
ATOM   4984 C  CD2 . HIS A 1 653 ? 9.93279   11.49219  9.31861   1.000 44.75591  ?  653  HIS A CD2 1 
ATOM   4985 C  CE1 . HIS A 1 653 ? 10.04614  13.60225  9.91198   1.000 47.69326  ?  653  HIS A CE1 1 
ATOM   4986 N  NE2 . HIS A 1 653 ? 9.55686   12.42357  10.25745  1.000 45.98238  ?  653  HIS A NE2 1 
ATOM   4987 N  N   . GLY A 1 654 ? 10.38964  11.00675  3.69011   1.000 36.49622  ?  654  GLY A N   1 
ATOM   4988 C  CA  . GLY A 1 654 ? 10.90808  10.62080  2.38927   1.000 35.99649  ?  654  GLY A CA  1 
ATOM   4989 C  C   . GLY A 1 654 ? 11.84576  9.42111   2.39685   1.000 38.74400  ?  654  GLY A C   1 
ATOM   4990 O  O   . GLY A 1 654 ? 12.70401  9.31509   1.51984   1.000 35.55886  ?  654  GLY A O   1 
ATOM   4991 N  N   . ILE A 1 655 ? 11.69833  8.50714   3.36136   1.000 38.44903  ?  655  ILE A N   1 
ATOM   4992 C  CA  . ILE A 1 655 ? 12.61013  7.36288   3.45289   1.000 36.34320  ?  655  ILE A CA  1 
ATOM   4993 C  C   . ILE A 1 655 ? 12.58387  6.54082   2.17098   1.000 32.59144  ?  655  ILE A C   1 
ATOM   4994 O  O   . ILE A 1 655 ? 13.62849  6.08244   1.69042   1.000 35.16281  ?  655  ILE A O   1 
ATOM   4995 C  CB  . ILE A 1 655 ? 12.27261  6.48516   4.67232   1.000 27.75555  ?  655  ILE A CB  1 
ATOM   4996 C  CG1 . ILE A 1 655 ? 12.20940  7.32627   5.94271   1.000 32.80902  ?  655  ILE A CG1 1 
ATOM   4997 C  CG2 . ILE A 1 655 ? 13.34637  5.39613   4.81762   1.000 30.25496  ?  655  ILE A CG2 1 
ATOM   4998 C  CD1 . ILE A 1 655 ? 13.50029  8.08123   6.23922   1.000 35.57328  ?  655  ILE A CD1 1 
ATOM   4999 N  N   . THR A 1 656 ? 11.39597  6.34075   1.59785   1.000 37.29289  ?  656  THR A N   1 
ATOM   5000 C  CA  . THR A 1 656 ? 11.25089  5.36549   0.51446   1.000 42.49758  ?  656  THR A CA  1 
ATOM   5001 C  C   . THR A 1 656 ? 12.08946  5.75181   -0.69573  1.000 39.57827  ?  656  THR A C   1 
ATOM   5002 O  O   . THR A 1 656 ? 12.81568  4.91857   -1.25212  1.000 34.09920  ?  656  THR A O   1 
ATOM   5003 C  CB  . THR A 1 656 ? 9.78107   5.21653   0.12524   1.000 41.27528  ?  656  THR A CB  1 
ATOM   5004 O  OG1 . THR A 1 656 ? 9.10244   4.49785   1.16126   1.000 48.65238  ?  656  THR A OG1 1 
ATOM   5005 C  CG2 . THR A 1 656 ? 9.64971   4.43305   -1.18570  1.000 41.57558  ?  656  THR A CG2 1 
ATOM   5006 N  N   . THR A 1 657 ? 12.03541  7.02342   -1.09863  1.000 32.85203  ?  657  THR A N   1 
ATOM   5007 C  CA  . THR A 1 657 ? 12.80049  7.43371   -2.27283  1.000 39.49849  ?  657  THR A CA  1 
ATOM   5008 C  C   . THR A 1 657 ? 14.26847  7.69988   -1.94979  1.000 37.67294  ?  657  THR A C   1 
ATOM   5009 O  O   . THR A 1 657 ? 15.10585  7.68267   -2.86066  1.000 41.58688  ?  657  THR A O   1 
ATOM   5010 C  CB  . THR A 1 657 ? 12.18106  8.68289   -2.91306  1.000 48.49932  ?  657  THR A CB  1 
ATOM   5011 O  OG1 . THR A 1 657 ? 12.48154  9.80865   -2.09600  1.000 45.06540  ?  657  THR A OG1 1 
ATOM   5012 C  CG2 . THR A 1 657 ? 10.65982  8.54711   -2.98722  1.000 51.38075  ?  657  THR A CG2 1 
ATOM   5013 N  N   . LEU A 1 658 ? 14.59664  7.99653   -0.69044  1.000 35.68407  ?  658  LEU A N   1 
ATOM   5014 C  CA  . LEU A 1 658 ? 15.99533  8.00975   -0.30475  1.000 35.02321  ?  658  LEU A CA  1 
ATOM   5015 C  C   . LEU A 1 658 ? 16.62011  6.63448   -0.52920  1.000 34.48316  ?  658  LEU A C   1 
ATOM   5016 O  O   . LEU A 1 658 ? 17.73767  6.52452   -1.06224  1.000 33.33439  ?  658  LEU A O   1 
ATOM   5017 C  CB  . LEU A 1 658 ? 16.13746  8.42931   1.16328   1.000 35.65947  ?  658  LEU A CB  1 
ATOM   5018 C  CG  . LEU A 1 658 ? 16.06824  9.90876   1.57656   1.000 33.44078  ?  658  LEU A CG  1 
ATOM   5019 C  CD1 . LEU A 1 658 ? 16.38955  10.03862  3.08465   1.000 29.57677  ?  658  LEU A CD1 1 
ATOM   5020 C  CD2 . LEU A 1 658 ? 16.96776  10.82760  0.71140   1.000 30.73529  ?  658  LEU A CD2 1 
ATOM   5021 N  N   . LEU A 1 659 ? 15.91100  5.56824   -0.14933  1.000 30.76707  ?  659  LEU A N   1 
ATOM   5022 C  CA  . LEU A 1 659 ? 16.53831  4.25596   -0.19146  1.000 30.48974  ?  659  LEU A CA  1 
ATOM   5023 C  C   . LEU A 1 659 ? 16.25379  3.50416   -1.48296  1.000 32.03074  ?  659  LEU A C   1 
ATOM   5024 O  O   . LEU A 1 659 ? 16.83199  2.42553   -1.69459  1.000 31.30003  ?  659  LEU A O   1 
ATOM   5025 C  CB  . LEU A 1 659 ? 16.12014  3.42386   1.03138   1.000 29.65005  ?  659  LEU A CB  1 
ATOM   5026 C  CG  . LEU A 1 659 ? 16.90503  3.78341   2.31548   1.000 32.26327  ?  659  LEU A CG  1 
ATOM   5027 C  CD1 . LEU A 1 659 ? 16.31672  3.14868   3.55805   1.000 24.71141  ?  659  LEU A CD1 1 
ATOM   5028 C  CD2 . LEU A 1 659 ? 18.40833  3.42096   2.19471   1.000 29.97036  ?  659  LEU A CD2 1 
ATOM   5029 N  N   . THR A 1 660 ? 15.41614  4.05742   -2.35969  1.000 32.90547  ?  660  THR A N   1 
ATOM   5030 C  CA  . THR A 1 660 ? 15.15683  3.42448   -3.65029  1.000 34.36346  ?  660  THR A CA  1 
ATOM   5031 C  C   . THR A 1 660 ? 16.37183  3.60690   -4.54984  1.000 33.39134  ?  660  THR A C   1 
ATOM   5032 O  O   . THR A 1 660 ? 16.88182  4.72292   -4.69459  1.000 31.54761  ?  660  THR A O   1 
ATOM   5033 C  CB  . THR A 1 660 ? 13.90732  4.02088   -4.30626  1.000 37.37738  ?  660  THR A CB  1 
ATOM   5034 O  OG1 . THR A 1 660 ? 12.72735  3.55289   -3.63299  1.000 35.45966  ?  660  THR A OG1 1 
ATOM   5035 C  CG2 . THR A 1 660 ? 13.80817  3.59513   -5.77709  1.000 35.40005  ?  660  THR A CG2 1 
ATOM   5036 N  N   . ALA A 1 661 ? 16.86194  2.50266   -5.11119  1.000 25.97690  ?  661  ALA A N   1 
ATOM   5037 C  CA  . ALA A 1 661 ? 18.07037  2.53962   -5.93022  1.000 29.89809  ?  661  ALA A CA  1 
ATOM   5038 C  C   . ALA A 1 661 ? 17.80694  3.14875   -7.30949  1.000 36.29597  ?  661  ALA A C   1 
ATOM   5039 O  O   . ALA A 1 661 ? 16.79760  2.84984   -7.96304  1.000 31.53399  ?  661  ALA A O   1 
ATOM   5040 C  CB  . ALA A 1 661 ? 18.63583  1.11733   -6.08537  1.000 33.75654  ?  661  ALA A CB  1 
ATOM   5041 N  N   . GLU A 1 662 ? 18.74140  3.99274   -7.75327  1.000 36.96262  ?  662  GLU A N   1 
ATOM   5042 C  CA  . GLU A 1 662 ? 18.76790  4.55449   -9.09893  1.000 36.64350  ?  662  GLU A CA  1 
ATOM   5043 C  C   . GLU A 1 662 ? 19.92485  3.94961   -9.87294  1.000 36.25033  ?  662  GLU A C   1 
ATOM   5044 O  O   . GLU A 1 662 ? 21.06006  3.95295   -9.39170  1.000 36.96366  ?  662  GLU A O   1 
ATOM   5045 C  CB  . GLU A 1 662 ? 18.93286  6.07445   -9.06423  1.000 40.56949  ?  662  GLU A CB  1 
ATOM   5046 C  CG  . GLU A 1 662 ? 17.64986  6.74877   -8.70125  1.000 45.46760  ?  662  GLU A CG  1 
ATOM   5047 C  CD  . GLU A 1 662 ? 17.75686  8.23133   -8.52305  1.000 52.65550  ?  662  GLU A CD  1 
ATOM   5048 O  OE1 . GLU A 1 662 ? 18.22908  8.91090   -9.45955  1.000 56.06383  ?  662  GLU A OE1 1 
ATOM   5049 O  OE2 . GLU A 1 662 ? 17.32926  8.71420   -7.44531  1.000 58.24184  -1 662  GLU A OE2 1 
ATOM   5050 N  N   . ALA A 1 663 ? 19.64103  3.44701   -11.06957 1.000 40.11174  ?  663  ALA A N   1 
ATOM   5051 C  CA  . ALA A 1 663 ? 20.65590  2.85333   -11.92529 1.000 39.63380  ?  663  ALA A CA  1 
ATOM   5052 C  C   . ALA A 1 663 ? 20.76553  3.61245   -13.24125 1.000 40.04046  ?  663  ALA A C   1 
ATOM   5053 O  O   . ALA A 1 663 ? 19.83530  4.30003   -13.68055 1.000 42.61173  ?  663  ALA A O   1 
ATOM   5054 C  CB  . ALA A 1 663 ? 20.37053  1.36862   -12.19679 1.000 41.46298  ?  663  ALA A CB  1 
ATOM   5055 N  N   . SER A 1 664 ? 21.94089  3.49959   -13.84729 1.000 40.39270  ?  664  SER A N   1 
ATOM   5056 C  CA  . SER A 1 664 ? 22.22686  4.10729   -15.13474 1.000 38.11876  ?  664  SER A CA  1 
ATOM   5057 C  C   . SER A 1 664 ? 23.61493  3.65883   -15.54203 1.000 37.74166  ?  664  SER A C   1 
ATOM   5058 O  O   . SER A 1 664 ? 24.40470  3.22199   -14.70787 1.000 36.09580  ?  664  SER A O   1 
ATOM   5059 C  CB  . SER A 1 664 ? 22.14536  5.63302   -15.07835 1.000 34.99732  ?  664  SER A CB  1 
ATOM   5060 O  OG  . SER A 1 664 ? 23.37322  6.20851   -14.69586 1.000 39.38243  ?  664  SER A OG  1 
ATOM   5061 N  N   . ASN A 1 665 ? 23.90951  3.80032   -16.83266 1.000 39.05913  ?  665  ASN A N   1 
ATOM   5062 C  CA  . ASN A 1 665 ? 25.21473  3.40315   -17.33797 1.000 39.63156  ?  665  ASN A CA  1 
ATOM   5063 C  C   . ASN A 1 665 ? 26.31779  4.23377   -16.70808 1.000 39.11982  ?  665  ASN A C   1 
ATOM   5064 O  O   . ASN A 1 665 ? 27.40070  3.71419   -16.39121 1.000 37.48524  ?  665  ASN A O   1 
ATOM   5065 C  CB  . ASN A 1 665 ? 25.25380  3.52319   -18.85940 1.000 43.83957  ?  665  ASN A CB  1 
ATOM   5066 C  CG  . ASN A 1 665 ? 24.77348  2.26586   -19.54120 1.000 48.88270  ?  665  ASN A CG  1 
ATOM   5067 O  OD1 . ASN A 1 665 ? 23.66267  2.22064   -20.06467 1.000 60.42119  ?  665  ASN A OD1 1 
ATOM   5068 N  ND2 . ASN A 1 665 ? 25.60231  1.23141   -19.53285 1.000 50.64856  ?  665  ASN A ND2 1 
ATOM   5069 N  N   . GLU A 1 666 ? 26.05023  5.51734   -16.48214 1.000 38.55509  ?  666  GLU A N   1 
ATOM   5070 C  CA  . GLU A 1 666 ? 27.05266  6.37658   -15.86926 1.000 40.98466  ?  666  GLU A CA  1 
ATOM   5071 C  C   . GLU A 1 666 ? 27.20483  6.10986   -14.37217 1.000 41.93703  ?  666  GLU A C   1 
ATOM   5072 O  O   . GLU A 1 666 ? 28.32917  6.11156   -13.85261 1.000 40.49342  ?  666  GLU A O   1 
ATOM   5073 C  CB  . GLU A 1 666 ? 26.69470  7.83041   -16.12255 1.000 39.42078  ?  666  GLU A CB  1 
ATOM   5074 C  CG  . GLU A 1 666 ? 27.21031  8.31225   -17.44057 1.000 52.07453  ?  666  GLU A CG  1 
ATOM   5075 C  CD  . GLU A 1 666 ? 28.72435  8.31124   -17.47010 1.000 55.52663  ?  666  GLU A CD  1 
ATOM   5076 O  OE1 . GLU A 1 666 ? 29.33369  8.81797   -16.50017 1.000 53.28122  ?  666  GLU A OE1 1 
ATOM   5077 O  OE2 . GLU A 1 666 ? 29.29906  7.80112   -18.45937 1.000 56.87688  -1 666  GLU A OE2 1 
ATOM   5078 N  N   . ASN A 1 667 ? 26.09946  5.87976   -13.66381 1.000 36.90710  ?  667  ASN A N   1 
ATOM   5079 C  CA  . ASN A 1 667 ? 26.12649  5.66099   -12.21416 1.000 36.39989  ?  667  ASN A CA  1 
ATOM   5080 C  C   . ASN A 1 667 ? 25.39449  4.35137   -11.94318 1.000 34.71647  ?  667  ASN A C   1 
ATOM   5081 O  O   . ASN A 1 667 ? 24.17478  4.32625   -11.71748 1.000 33.00803  ?  667  ASN A O   1 
ATOM   5082 C  CB  . ASN A 1 667 ? 25.52761  6.84902   -11.46548 1.000 30.72230  ?  667  ASN A CB  1 
ATOM   5083 C  CG  . ASN A 1 667 ? 26.31102  8.14063   -11.71919 1.000 41.05309  ?  667  ASN A CG  1 
ATOM   5084 O  OD1 . ASN A 1 667 ? 27.26642  8.46785   -11.00943 1.000 36.52642  ?  667  ASN A OD1 1 
ATOM   5085 N  ND2 . ASN A 1 667 ? 25.94224  8.84398   -12.78406 1.000 38.86819  ?  667  ASN A ND2 1 
ATOM   5086 N  N   . PRO A 1 668 ? 26.11514  3.24057   -11.96757 1.000 37.17804  ?  668  PRO A N   1 
ATOM   5087 C  CA  . PRO A 1 668 ? 25.45241  1.92926   -12.00094 1.000 31.53740  ?  668  PRO A CA  1 
ATOM   5088 C  C   . PRO A 1 668 ? 24.44949  1.70863   -10.88326 1.000 33.45305  ?  668  PRO A C   1 
ATOM   5089 O  O   . PRO A 1 668 ? 23.40441  1.09876   -11.12537 1.000 33.21935  ?  668  PRO A O   1 
ATOM   5090 C  CB  . PRO A 1 668 ? 26.63438  0.96940   -11.89659 1.000 32.26656  ?  668  PRO A CB  1 
ATOM   5091 C  CG  . PRO A 1 668 ? 27.71288  1.67847   -12.62172 1.000 35.47635  ?  668  PRO A CG  1 
ATOM   5092 C  CD  . PRO A 1 668 ? 27.56020  3.13771   -12.23145 1.000 32.07259  ?  668  PRO A CD  1 
ATOM   5093 N  N   . LEU A 1 669 ? 24.69426  2.23255   -9.68451  1.000 35.91908  ?  669  LEU A N   1 
ATOM   5094 C  CA  . LEU A 1 669 ? 23.85391  1.88304   -8.53537  1.000 33.36869  ?  669  LEU A CA  1 
ATOM   5095 C  C   . LEU A 1 669 ? 23.94738  2.99021   -7.49607  1.000 27.43374  ?  669  LEU A C   1 
ATOM   5096 O  O   . LEU A 1 669 ? 24.97865  3.13158   -6.84362  1.000 32.93544  ?  669  LEU A O   1 
ATOM   5097 C  CB  . LEU A 1 669 ? 24.30293  0.54143   -7.96228  1.000 33.09830  ?  669  LEU A CB  1 
ATOM   5098 C  CG  . LEU A 1 669 ? 23.59251  0.02062   -6.71873  1.000 33.97552  ?  669  LEU A CG  1 
ATOM   5099 C  CD1 . LEU A 1 669 ? 22.12856  0.17994   -6.95072  1.000 32.83420  ?  669  LEU A CD1 1 
ATOM   5100 C  CD2 . LEU A 1 669 ? 23.97988  -1.44753  -6.43150  1.000 33.81738  ?  669  LEU A CD2 1 
ATOM   5101 N  N   . ALA A 1 670 ? 22.88761  3.77551   -7.33689  1.000 34.13671  ?  670  ALA A N   1 
ATOM   5102 C  CA  . ALA A 1 670 ? 22.90226  4.93113   -6.44621  1.000 33.03289  ?  670  ALA A CA  1 
ATOM   5103 C  C   . ALA A 1 670 ? 21.83866  4.76267   -5.35812  1.000 29.21584  ?  670  ALA A C   1 
ATOM   5104 O  O   . ALA A 1 670 ? 20.65060  4.69377   -5.66791  1.000 27.50586  ?  670  ALA A O   1 
ATOM   5105 C  CB  . ALA A 1 670 ? 22.66323  6.21431   -7.24095  1.000 29.67806  ?  670  ALA A CB  1 
ATOM   5106 N  N   . ILE A 1 671 ? 22.26433  4.70183   -4.09088  1.000 30.01190  ?  671  ILE A N   1 
ATOM   5107 C  CA  . ILE A 1 671 ? 21.36111  4.61773   -2.93654  1.000 29.17695  ?  671  ILE A CA  1 
ATOM   5108 C  C   . ILE A 1 671 ? 21.88715  5.55604   -1.86181  1.000 30.78687  ?  671  ILE A C   1 
ATOM   5109 O  O   . ILE A 1 671 ? 23.10198  5.66909   -1.67176  1.000 33.23713  ?  671  ILE A O   1 
ATOM   5110 C  CB  . ILE A 1 671 ? 21.24877  3.17914   -2.36514  1.000 32.21607  ?  671  ILE A CB  1 
ATOM   5111 C  CG1 . ILE A 1 671 ? 20.57556  2.23195   -3.34874  1.000 29.90666  ?  671  ILE A CG1 1 
ATOM   5112 C  CG2 . ILE A 1 671 ? 20.50765  3.14671   -1.00416  1.000 25.04032  ?  671  ILE A CG2 1 
ATOM   5113 C  CD1 . ILE A 1 671 ? 20.99729  0.77014   -3.12665  1.000 29.11794  ?  671  ILE A CD1 1 
ATOM   5114 N  N   . LYS A 1 672 ? 20.98494  6.22029   -1.14773  1.000 30.40707  ?  672  LYS A N   1 
ATOM   5115 C  CA  . LYS A 1 672 ? 21.38996  7.14982   -0.09774  1.000 30.75508  ?  672  LYS A CA  1 
ATOM   5116 C  C   . LYS A 1 672 ? 21.32400  6.50178   1.29279   1.000 28.34640  ?  672  LYS A C   1 
ATOM   5117 O  O   . LYS A 1 672 ? 20.58550  6.94008   2.16502   1.000 28.07972  ?  672  LYS A O   1 
ATOM   5118 C  CB  . LYS A 1 672 ? 20.53915  8.41859   -0.16598  1.000 31.21929  ?  672  LYS A CB  1 
ATOM   5119 C  CG  . LYS A 1 672 ? 20.35810  9.00118   -1.56242  1.000 35.55957  ?  672  LYS A CG  1 
ATOM   5120 C  CD  . LYS A 1 672 ? 21.42883  10.03318  -1.92724  1.000 43.96498  ?  672  LYS A CD  1 
ATOM   5121 C  CE  . LYS A 1 672 ? 22.45893  9.51218   -3.04248  1.000 36.17498  ?  672  LYS A CE  1 
ATOM   5122 N  NZ  . LYS A 1 672 ? 23.71910  10.30453  -3.05142  1.000 24.21625  ?  672  LYS A NZ  1 
ATOM   5123 N  N   . PHE A 1 673 ? 22.15137  5.47229   1.51791   1.000 27.53772  ?  673  PHE A N   1 
ATOM   5124 C  CA  . PHE A 1 673 ? 22.18825  4.78329   2.81974   1.000 27.55996  ?  673  PHE A CA  1 
ATOM   5125 C  C   . PHE A 1 673 ? 22.44868  5.74772   3.97507   1.000 30.44657  ?  673  PHE A C   1 
ATOM   5126 O  O   . PHE A 1 673 ? 21.79068  5.67586   5.02660   1.000 27.26301  ?  673  PHE A O   1 
ATOM   5127 C  CB  . PHE A 1 673 ? 23.30282  3.72863   2.84657   1.000 25.44508  ?  673  PHE A CB  1 
ATOM   5128 C  CG  . PHE A 1 673 ? 23.05346  2.53739   1.98292   1.000 26.60147  ?  673  PHE A CG  1 
ATOM   5129 C  CD1 . PHE A 1 673 ? 22.16748  1.52267   2.39295   1.000 27.30594  ?  673  PHE A CD1 1 
ATOM   5130 C  CD2 . PHE A 1 673 ? 23.70988  2.40592   0.78411   1.000 21.68011  ?  673  PHE A CD2 1 
ATOM   5131 C  CE1 . PHE A 1 673 ? 21.93537  0.41121   1.59451   1.000 23.44695  ?  673  PHE A CE1 1 
ATOM   5132 C  CE2 . PHE A 1 673 ? 23.48497  1.28661   -0.02561  1.000 26.47258  ?  673  PHE A CE2 1 
ATOM   5133 C  CZ  . PHE A 1 673 ? 22.60460  0.28661   0.38363   1.000 24.19841  ?  673  PHE A CZ  1 
ATOM   5134 N  N   . ARG A 1 674 ? 23.49719  6.58251   3.83551   1.000 24.92519  ?  674  ARG A N   1 
ATOM   5135 C  CA  . ARG A 1 674 ? 23.92552  7.43330   4.94209   1.000 32.79915  ?  674  ARG A CA  1 
ATOM   5136 C  C   . ARG A 1 674 ? 22.84938  8.45486   5.30847   1.000 30.36555  ?  674  ARG A C   1 
ATOM   5137 O  O   . ARG A 1 674 ? 22.45799  8.58831   6.48316   1.000 34.57049  ?  674  ARG A O   1 
ATOM   5138 C  CB  . ARG A 1 674 ? 25.23591  8.13134   4.56717   1.000 32.99913  ?  674  ARG A CB  1 
ATOM   5139 C  CG  . ARG A 1 674 ? 25.87708  8.86164   5.74577   1.000 31.43085  ?  674  ARG A CG  1 
ATOM   5140 C  CD  . ARG A 1 674 ? 26.49770  7.89203   6.77539   1.000 28.85159  ?  674  ARG A CD  1 
ATOM   5141 N  NE  . ARG A 1 674 ? 27.48251  6.99550   6.16977   1.000 32.78774  ?  674  ARG A NE  1 
ATOM   5142 C  CZ  . ARG A 1 674 ? 28.77106  7.28375   6.02344   1.000 34.22907  ?  674  ARG A CZ  1 
ATOM   5143 N  NH1 . ARG A 1 674 ? 29.27781  8.41241   6.47243   1.000 28.40406  ?  674  ARG A NH1 1 
ATOM   5144 N  NH2 . ARG A 1 674 ? 29.58168  6.39077   5.45355   1.000 37.22008  ?  674  ARG A NH2 1 
ATOM   5145 N  N   . THR A 1 675 ? 22.33504  9.16464   4.29967   1.000 30.90963  ?  675  THR A N   1 
ATOM   5146 C  CA  . THR A 1 675 ? 21.30838  10.18134  4.53909   1.000 30.20683  ?  675  THR A CA  1 
ATOM   5147 C  C   . THR A 1 675 ? 20.03952  9.54974   5.08664   1.000 27.50357  ?  675  THR A C   1 
ATOM   5148 O  O   . THR A 1 675 ? 19.41575  10.09421  6.00079   1.000 29.71999  ?  675  THR A O   1 
ATOM   5149 C  CB  . THR A 1 675 ? 21.00712  10.95379  3.23941   1.000 32.95688  ?  675  THR A CB  1 
ATOM   5150 O  OG1 . THR A 1 675 ? 22.20343  11.58819  2.75662   1.000 32.91700  ?  675  THR A OG1 1 
ATOM   5151 C  CG2 . THR A 1 675 ? 19.89714  12.02007  3.44561   1.000 32.09722  ?  675  THR A CG2 1 
ATOM   5152 N  N   . ALA A 1 676 ? 19.65368  8.38159   4.55553   1.000 30.51724  ?  676  ALA A N   1 
ATOM   5153 C  CA  . ALA A 1 676 ? 18.44580  7.70640   5.03407   1.000 26.90435  ?  676  ALA A CA  1 
ATOM   5154 C  C   . ALA A 1 676 ? 18.57007  7.31260   6.49961   1.000 29.26853  ?  676  ALA A C   1 
ATOM   5155 O  O   . ALA A 1 676 ? 17.65016  7.54252   7.28560   1.000 31.78477  ?  676  ALA A O   1 
ATOM   5156 C  CB  . ALA A 1 676 ? 18.14352  6.47619   4.18057   1.000 25.83932  ?  676  ALA A CB  1 
ATOM   5157 N  N   . ALA A 1 677 ? 19.69802  6.70457   6.88111   1.000 30.27636  ?  677  ALA A N   1 
ATOM   5158 C  CA  . ALA A 1 677 ? 19.92252  6.32742   8.27396   1.000 27.51060  ?  677  ALA A CA  1 
ATOM   5159 C  C   . ALA A 1 677 ? 19.81095  7.53683   9.20317   1.000 33.29566  ?  677  ALA A C   1 
ATOM   5160 O  O   . ALA A 1 677 ? 19.14626  7.48156   10.24978  1.000 34.66583  ?  677  ALA A O   1 
ATOM   5161 C  CB  . ALA A 1 677 ? 21.30692  5.69424   8.40464   1.000 25.32149  ?  677  ALA A CB  1 
ATOM   5162 N  N   . GLU A 1 678 ? 20.44581  8.65296   8.82377   1.000 31.75265  ?  678  GLU A N   1 
ATOM   5163 C  CA  . GLU A 1 678 ? 20.37461  9.84042   9.68537   1.000 39.77874  ?  678  GLU A CA  1 
ATOM   5164 C  C   . GLU A 1 678 ? 18.95149  10.37348  9.77323   1.000 35.32997  ?  678  GLU A C   1 
ATOM   5165 O  O   . GLU A 1 678 ? 18.49346  10.76805  10.85160  1.000 36.69192  ?  678  GLU A O   1 
ATOM   5166 C  CB  . GLU A 1 678 ? 21.33667  10.93081  9.19188   1.000 35.80332  ?  678  GLU A CB  1 
ATOM   5167 C  CG  . GLU A 1 678 ? 22.64542  10.99684  9.98716   1.000 48.77273  ?  678  GLU A CG  1 
ATOM   5168 C  CD  . GLU A 1 678 ? 23.82351  11.49860  9.15593   1.000 56.81656  ?  678  GLU A CD  1 
ATOM   5169 O  OE1 . GLU A 1 678 ? 23.65040  12.53003  8.45795   1.000 50.10662  ?  678  GLU A OE1 1 
ATOM   5170 O  OE2 . GLU A 1 678 ? 24.91646  10.86179  9.18741   1.000 54.65285  -1 678  GLU A OE2 1 
ATOM   5171 N  N   . ARG A 1 679 ? 18.23276  10.38645  8.65121   1.000 34.31455  ?  679  ARG A N   1 
ATOM   5172 C  CA  . ARG A 1 679 ? 16.84500  10.83654  8.67102   1.000 35.04998  ?  679  ARG A CA  1 
ATOM   5173 C  C   . ARG A 1 679 ? 15.96387  9.92456   9.51557   1.000 39.19868  ?  679  ARG A C   1 
ATOM   5174 O  O   . ARG A 1 679 ? 15.02050  10.39734  10.16895  1.000 36.90445  ?  679  ARG A O   1 
ATOM   5175 C  CB  . ARG A 1 679 ? 16.29095  10.92653  7.24207   1.000 35.93145  ?  679  ARG A CB  1 
ATOM   5176 C  CG  . ARG A 1 679 ? 15.20490  11.97569  7.13897   1.000 43.52879  ?  679  ARG A CG  1 
ATOM   5177 C  CD  . ARG A 1 679 ? 14.99231  12.47323  5.75056   1.000 46.17190  ?  679  ARG A CD  1 
ATOM   5178 N  NE  . ARG A 1 679 ? 16.06595  13.31638  5.24310   1.000 45.82301  ?  679  ARG A NE  1 
ATOM   5179 C  CZ  . ARG A 1 679 ? 16.14342  13.66686  3.96698   1.000 49.55603  ?  679  ARG A CZ  1 
ATOM   5180 N  NH1 . ARG A 1 679 ? 15.22247  13.28310  3.09754   1.000 51.18201  ?  679  ARG A NH1 1 
ATOM   5181 N  NH2 . ARG A 1 679 ? 17.15984  14.42163  3.55367   1.000 48.00936  ?  679  ARG A NH2 1 
ATOM   5182 N  N   . PHE A 1 680 ? 16.21067  8.60827   9.46614   1.000 35.96129  ?  680  PHE A N   1 
ATOM   5183 C  CA  . PHE A 1 680 ? 15.41744  7.69416   10.27422  1.000 34.46566  ?  680  PHE A CA  1 
ATOM   5184 C  C   . PHE A 1 680 ? 15.65525  7.93826   11.75779  1.000 37.18048  ?  680  PHE A C   1 
ATOM   5185 O  O   . PHE A 1 680 ? 14.75573  7.73501   12.57065  1.000 37.28486  ?  680  PHE A O   1 
ATOM   5186 C  CB  . PHE A 1 680 ? 15.74291  6.24206   9.91151   1.000 37.99234  ?  680  PHE A CB  1 
ATOM   5187 C  CG  . PHE A 1 680 ? 14.58687  5.30336   10.08094  1.000 30.83555  ?  680  PHE A CG  1 
ATOM   5188 C  CD1 . PHE A 1 680 ? 14.36241  4.67653   11.29165  1.000 33.63063  ?  680  PHE A CD1 1 
ATOM   5189 C  CD2 . PHE A 1 680 ? 13.70655  5.06888   9.04267   1.000 34.45509  ?  680  PHE A CD2 1 
ATOM   5190 C  CE1 . PHE A 1 680 ? 13.27282  3.80849   11.45595  1.000 33.03373  ?  680  PHE A CE1 1 
ATOM   5191 C  CE2 . PHE A 1 680 ? 12.61863  4.19288   9.20165   1.000 33.07715  ?  680  PHE A CE2 1 
ATOM   5192 C  CZ  . PHE A 1 680 ? 12.40487  3.57400   10.41260  1.000 29.34155  ?  680  PHE A CZ  1 
ATOM   5193 N  N   . HIS A 1 681 ? 16.84704  8.42889   12.11651  1.000 45.81522  ?  681  HIS A N   1 
ATOM   5194 C  CA  . HIS A 1 681 ? 17.11856  8.77953   13.51301  1.000 47.82318  ?  681  HIS A CA  1 
ATOM   5195 C  C   . HIS A 1 681 ? 16.05665  9.68662   14.14725  1.000 49.67595  ?  681  HIS A C   1 
ATOM   5196 O  O   . HIS A 1 681 ? 15.95355  9.73148   15.38006  1.000 52.18433  ?  681  HIS A O   1 
ATOM   5197 C  CB  . HIS A 1 681 ? 18.49163  9.44207   13.63493  1.000 50.48203  ?  681  HIS A CB  1 
ATOM   5198 C  CG  . HIS A 1 681 ? 19.04336  9.41462   15.02507  1.000 61.72720  ?  681  HIS A CG  1 
ATOM   5199 N  ND1 . HIS A 1 681 ? 19.18183  8.24805   15.74779  1.000 58.01373  ?  681  HIS A ND1 1 
ATOM   5200 C  CD2 . HIS A 1 681 ? 19.45372  10.41576  15.84273  1.000 64.45714  ?  681  HIS A CD2 1 
ATOM   5201 C  CE1 . HIS A 1 681 ? 19.68157  8.53088   16.94006  1.000 66.81541  ?  681  HIS A CE1 1 
ATOM   5202 N  NE2 . HIS A 1 681 ? 19.84551  9.83977   17.02751  1.000 63.39691  ?  681  HIS A NE2 1 
ATOM   5203 N  N   . LEU A 1 682 ? 15.25661  10.40548  13.35804  1.000 48.88322  ?  682  LEU A N   1 
ATOM   5204 C  CA  . LEU A 1 682 ? 14.17052  11.19157  13.94849  1.000 46.01563  ?  682  LEU A CA  1 
ATOM   5205 C  C   . LEU A 1 682 ? 12.97069  10.35240  14.40871  1.000 48.74450  ?  682  LEU A C   1 
ATOM   5206 O  O   . LEU A 1 682 ? 11.97578  10.94793  14.83408  1.000 55.24627  ?  682  LEU A O   1 
ATOM   5207 C  CB  . LEU A 1 682 ? 13.67822  12.26300  12.96311  1.000 52.11422  ?  682  LEU A CB  1 
ATOM   5208 C  CG  . LEU A 1 682 ? 14.73546  13.03337  12.15331  1.000 56.24179  ?  682  LEU A CG  1 
ATOM   5209 C  CD1 . LEU A 1 682 ? 14.16704  13.54606  10.81792  1.000 50.45577  ?  682  LEU A CD1 1 
ATOM   5210 C  CD2 . LEU A 1 682 ? 15.33487  14.17725  12.96993  1.000 51.33510  ?  682  LEU A CD2 1 
ATOM   5211 N  N   . ILE A 1 683 ? 13.01929  9.01308   14.35524  1.000 44.41133  ?  683  ILE A N   1 
ATOM   5212 C  CA  . ILE A 1 683 ? 11.87106  8.21175   14.79545  1.000 47.47264  ?  683  ILE A CA  1 
ATOM   5213 C  C   . ILE A 1 683 ? 11.54826  8.42159   16.27354  1.000 52.46148  ?  683  ILE A C   1 
ATOM   5214 O  O   . ILE A 1 683 ? 10.42125  8.15607   16.70991  1.000 50.74125  ?  683  ILE A O   1 
ATOM   5215 C  CB  . ILE A 1 683 ? 12.12679  6.72238   14.51711  1.000 47.63855  ?  683  ILE A CB  1 
ATOM   5216 C  CG1 . ILE A 1 683 ? 10.92663  5.86632   14.94240  1.000 40.74468  ?  683  ILE A CG1 1 
ATOM   5217 C  CG2 . ILE A 1 683 ? 13.39998  6.28870   15.21706  1.000 48.43977  ?  683  ILE A CG2 1 
ATOM   5218 C  CD1 . ILE A 1 683 ? 10.63519  4.72122   14.02248  1.000 40.42360  ?  683  ILE A CD1 1 
ATOM   5219 N  N   . ASP A 1 684 ? 12.51456  8.90437   17.05415  1.000 48.92097  ?  684  ASP A N   1 
ATOM   5220 C  CA  . ASP A 1 684 ? 12.34677  9.18502   18.47221  1.000 59.24382  ?  684  ASP A CA  1 
ATOM   5221 C  C   . ASP A 1 684 ? 12.89857  10.56287  18.82613  1.000 61.26135  ?  684  ASP A C   1 
ATOM   5222 O  O   . ASP A 1 684 ? 13.39214  10.77011  19.94179  1.000 63.95677  ?  684  ASP A O   1 
ATOM   5223 C  CB  . ASP A 1 684 ? 13.03765  8.11347   19.31058  1.000 60.97104  ?  684  ASP A CB  1 
ATOM   5224 C  CG  . ASP A 1 684 ? 14.51271  7.96692   18.94347  1.000 63.92504  ?  684  ASP A CG  1 
ATOM   5225 O  OD1 . ASP A 1 684 ? 14.97623  8.66532   17.99977  1.000 58.83547  -1 684  ASP A OD1 1 
ATOM   5226 O  OD2 . ASP A 1 684 ? 15.21489  7.15995   19.59183  1.000 67.67256  -1 684  ASP A OD2 1 
ATOM   5227 N  N   . ASN A 1 685 ? 12.84941  11.50237  17.87970  1.000 55.93303  ?  685  ASN A N   1 
ATOM   5228 C  CA  . ASN A 1 685 ? 13.24814  12.89698  18.12585  1.000 67.94221  ?  685  ASN A CA  1 
ATOM   5229 C  C   . ASN A 1 685 ? 14.70448  13.00425  18.57760  1.000 69.00559  ?  685  ASN A C   1 
ATOM   5230 O  O   . ASN A 1 685 ? 15.05561  13.85092  19.40576  1.000 70.68493  ?  685  ASN A O   1 
ATOM   5231 C  CB  . ASN A 1 685 ? 12.31713  13.57223  19.13926  1.000 67.69895  ?  685  ASN A CB  1 
ATOM   5232 C  CG  . ASN A 1 685 ? 10.86732  13.61460  18.67114  1.000 73.15341  ?  685  ASN A CG  1 
ATOM   5233 O  OD1 . ASN A 1 685 ? 10.39218  12.72314  17.95484  1.000 71.70966  ?  685  ASN A OD1 1 
ATOM   5234 N  ND2 . ASN A 1 685 ? 10.14960  14.65271  19.09268  1.000 75.63888  ?  685  ASN A ND2 1 
ATOM   5235 N  N   . GLN A 1 686 ? 15.55499  12.14303  18.01273  1.000 68.65344  ?  686  GLN A N   1 
ATOM   5236 C  CA  . GLN A 1 686 ? 16.99098  12.11283  18.29199  1.000 68.19662  ?  686  GLN A CA  1 
ATOM   5237 C  C   . GLN A 1 686 ? 17.26035  11.85998  19.78017  1.000 70.22594  ?  686  GLN A C   1 
ATOM   5238 O  O   . GLN A 1 686 ? 17.83511  12.69174  20.49055  1.000 70.51093  ?  686  GLN A O   1 
ATOM   5239 C  CB  . GLN A 1 686 ? 17.66251  13.40310  17.80422  1.000 73.93755  ?  686  GLN A CB  1 
ATOM   5240 C  CG  . GLN A 1 686 ? 18.00257  13.37387  16.31432  1.000 73.53485  ?  686  GLN A CG  1 
ATOM   5241 C  CD  . GLN A 1 686 ? 17.99733  14.74727  15.65995  1.000 78.72084  ?  686  GLN A CD  1 
ATOM   5242 O  OE1 . GLN A 1 686 ? 17.17474  15.60726  15.99089  1.000 81.76564  ?  686  GLN A OE1 1 
ATOM   5243 N  NE2 . GLN A 1 686 ? 18.92475  14.96113  14.72686  1.000 74.86098  ?  686  GLN A NE2 1 
ATOM   5244 N  N   . GLY A 1 687 ? 16.82298  10.68758  20.23964  1.000 67.49326  ?  687  GLY A N   1 
ATOM   5245 C  CA  . GLY A 1 687 ? 17.04180  10.29733  21.62767  1.000 67.41601  ?  687  GLY A CA  1 
ATOM   5246 C  C   . GLY A 1 687 ? 18.51880  10.07585  21.92323  1.000 69.05716  ?  687  GLY A C   1 
ATOM   5247 O  O   . GLY A 1 687 ? 19.18701  9.29363   21.23519  1.000 68.91202  ?  687  GLY A O   1 
ATOM   5248 N  N   . VAL A 1 688 ? 19.03714  10.74217  22.96283  1.000 66.13801  ?  688  VAL A N   1 
ATOM   5249 C  CA  . VAL A 1 688 ? 20.42148  10.54179  23.39548  1.000 68.78092  ?  688  VAL A CA  1 
ATOM   5250 C  C   . VAL A 1 688 ? 20.43219  9.84143   24.75444  1.000 64.28042  ?  688  VAL A C   1 
ATOM   5251 O  O   . VAL A 1 688 ? 19.70995  10.23755  25.68252  1.000 60.25293  ?  688  VAL A O   1 
ATOM   5252 C  CB  . VAL A 1 688 ? 21.22086  11.86033  23.42973  1.000 66.55109  ?  688  VAL A CB  1 
ATOM   5253 C  CG1 . VAL A 1 688 ? 20.97185  12.65321  24.69992  1.000 63.38535  ?  688  VAL A CG1 1 
ATOM   5254 C  CG2 . VAL A 1 688 ? 22.70601  11.56957  23.28029  1.000 67.27348  ?  688  VAL A CG2 1 
ATOM   5255 N  N   . ALA A 1 689 ? 21.23055  8.77677   24.85293  1.000 60.22902  ?  689  ALA A N   1 
ATOM   5256 C  CA  . ALA A 1 689 ? 21.33259  7.98668   26.06996  1.000 51.95733  ?  689  ALA A CA  1 
ATOM   5257 C  C   . ALA A 1 689 ? 22.22410  8.67943   27.09216  1.000 51.76876  ?  689  ALA A C   1 
ATOM   5258 O  O   . ALA A 1 689 ? 23.11435  9.45484   26.74625  1.000 53.09546  ?  689  ALA A O   1 
ATOM   5259 C  CB  . ALA A 1 689 ? 21.87560  6.59993   25.76056  1.000 43.78606  ?  689  ALA A CB  1 
ATOM   5260 N  N   . LEU A 1 690 ? 21.98843  8.37153   28.36475  1.000 45.64621  ?  690  LEU A N   1 
ATOM   5261 C  CA  . LEU A 1 690 ? 22.64330  9.07582   29.45362  1.000 45.34406  ?  690  LEU A CA  1 
ATOM   5262 C  C   . LEU A 1 690 ? 22.65016  8.16004   30.67552  1.000 45.83344  ?  690  LEU A C   1 
ATOM   5263 O  O   . LEU A 1 690 ? 21.61065  7.60940   31.06283  1.000 43.47570  ?  690  LEU A O   1 
ATOM   5264 C  CB  . LEU A 1 690 ? 21.91166  10.40822  29.70797  1.000 48.37006  ?  690  LEU A CB  1 
ATOM   5265 C  CG  . LEU A 1 690 ? 22.51458  11.50598  30.57058  1.000 52.21893  ?  690  LEU A CG  1 
ATOM   5266 C  CD1 . LEU A 1 690 ? 22.63316  11.02158  31.98621  1.000 53.10951  ?  690  LEU A CD1 1 
ATOM   5267 C  CD2 . LEU A 1 690 ? 23.88430  11.94161  30.03388  1.000 52.81883  ?  690  LEU A CD2 1 
ATOM   5268 N  N   . ILE A 1 691 ? 23.82091  7.96517   31.24978  1.000 44.74126  ?  691  ILE A N   1 
ATOM   5269 C  CA  . ILE A 1 691 ? 23.99410  7.00870   32.32983  1.000 44.67792  ?  691  ILE A CA  1 
ATOM   5270 C  C   . ILE A 1 691 ? 23.83469  7.76424   33.63046  1.000 44.07312  ?  691  ILE A C   1 
ATOM   5271 O  O   . ILE A 1 691 ? 24.40099  8.84904   33.77855  1.000 44.50575  ?  691  ILE A O   1 
ATOM   5272 C  CB  . ILE A 1 691 ? 25.36607  6.32527   32.23998  1.000 38.94351  ?  691  ILE A CB  1 
ATOM   5273 C  CG1 . ILE A 1 691 ? 25.41991  5.46068   30.99059  1.000 37.59477  ?  691  ILE A CG1 1 
ATOM   5274 C  CG2 . ILE A 1 691 ? 25.66077  5.49864   33.50477  1.000 37.90272  ?  691  ILE A CG2 1 
ATOM   5275 C  CD1 . ILE A 1 691 ? 26.70575  4.69856   30.83774  1.000 40.16514  ?  691  ILE A CD1 1 
ATOM   5276 N  N   . VAL A 1 692 ? 23.02653  7.23250   34.54427  1.000 42.01649  ?  692  VAL A N   1 
ATOM   5277 C  CA  . VAL A 1 692 ? 22.71019  7.89735   35.80468  1.000 42.97663  ?  692  VAL A CA  1 
ATOM   5278 C  C   . VAL A 1 692 ? 23.17060  7.01893   36.95642  1.000 44.12680  ?  692  VAL A C   1 
ATOM   5279 O  O   . VAL A 1 692 ? 22.89543  5.81479   36.96239  1.000 42.60815  ?  692  VAL A O   1 
ATOM   5280 C  CB  . VAL A 1 692 ? 21.21695  8.25486   35.94856  1.000 45.63748  ?  692  VAL A CB  1 
ATOM   5281 C  CG1 . VAL A 1 692 ? 20.81874  9.25423   34.87806  1.000 41.60710  ?  692  VAL A CG1 1 
ATOM   5282 C  CG2 . VAL A 1 692 ? 20.31670  7.03518   35.91177  1.000 41.01779  ?  692  VAL A CG2 1 
ATOM   5283 N  N   . PRO A 1 693 ? 23.90016  7.56814   37.92317  1.000 47.44859  ?  693  PRO A N   1 
ATOM   5284 C  CA  . PRO A 1 693 ? 24.52268  6.79463   39.01568  1.000 48.70479  ?  693  PRO A CA  1 
ATOM   5285 C  C   . PRO A 1 693 ? 23.57365  6.52523   40.17945  1.000 48.61016  ?  693  PRO A C   1 
ATOM   5286 O  O   . PRO A 1 693 ? 23.86455  6.81163   41.34248  1.000 52.24982  ?  693  PRO A O   1 
ATOM   5287 C  CB  . PRO A 1 693 ? 25.69275  7.70095   39.42186  1.000 50.97583  ?  693  PRO A CB  1 
ATOM   5288 C  CG  . PRO A 1 693 ? 25.21070  9.08001   39.09262  1.000 49.47547  ?  693  PRO A CG  1 
ATOM   5289 C  CD  . PRO A 1 693 ? 24.43381  8.93668   37.83466  1.000 45.45648  ?  693  PRO A CD  1 
ATOM   5290 N  N   . PHE A 1 694 ? 22.42332  5.94993   39.87516  1.000 46.71671  ?  694  PHE A N   1 
ATOM   5291 C  CA  . PHE A 1 694 ? 21.45498  5.63984   40.91603  1.000 45.50223  ?  694  PHE A CA  1 
ATOM   5292 C  C   . PHE A 1 694 ? 21.94717  4.42927   41.70525  1.000 41.90209  ?  694  PHE A C   1 
ATOM   5293 O  O   . PHE A 1 694 ? 22.08798  3.34252   41.14162  1.000 44.30232  ?  694  PHE A O   1 
ATOM   5294 C  CB  . PHE A 1 694 ? 20.09359  5.38979   40.27154  1.000 36.87158  ?  694  PHE A CB  1 
ATOM   5295 C  CG  . PHE A 1 694 ? 19.08403  4.79279   41.18475  1.000 35.47023  ?  694  PHE A CG  1 
ATOM   5296 C  CD1 . PHE A 1 694 ? 18.42098  5.57806   42.10984  1.000 39.65063  ?  694  PHE A CD1 1 
ATOM   5297 C  CD2 . PHE A 1 694 ? 18.77526  3.43868   41.10983  1.000 36.87298  ?  694  PHE A CD2 1 
ATOM   5298 C  CE1 . PHE A 1 694 ? 17.46777  5.02672   42.94361  1.000 37.54036  ?  694  PHE A CE1 1 
ATOM   5299 C  CE2 . PHE A 1 694 ? 17.82780  2.87774   41.94753  1.000 34.29890  ?  694  PHE A CE2 1 
ATOM   5300 C  CZ  . PHE A 1 694 ? 17.16917  3.67146   42.86552  1.000 35.95090  ?  694  PHE A CZ  1 
ATOM   5301 N  N   . ILE A 1 695 ? 22.22177  4.61129   42.99911  1.000 45.97058  ?  695  ILE A N   1 
ATOM   5302 C  CA  . ILE A 1 695 ? 22.71493  3.52292   43.84842  1.000 38.81929  ?  695  ILE A CA  1 
ATOM   5303 C  C   . ILE A 1 695 ? 21.59476  2.51194   44.08438  1.000 39.21761  ?  695  ILE A C   1 
ATOM   5304 O  O   . ILE A 1 695 ? 20.57197  2.84825   44.69482  1.000 37.65844  ?  695  ILE A O   1 
ATOM   5305 C  CB  . ILE A 1 695 ? 23.25643  4.05076   45.19297  1.000 44.15026  ?  695  ILE A CB  1 
ATOM   5306 C  CG1 . ILE A 1 695 ? 24.49895  4.91682   44.99490  1.000 45.53908  ?  695  ILE A CG1 1 
ATOM   5307 C  CG2 . ILE A 1 695 ? 23.61454  2.89926   46.15438  1.000 39.21608  ?  695  ILE A CG2 1 
ATOM   5308 C  CD1 . ILE A 1 695 ? 24.42665  6.23389   45.72549  1.000 41.84389  ?  695  ILE A CD1 1 
ATOM   5309 N  N   . PRO A 1 696 ? 21.75284  1.26526   43.66323  1.000 42.23258  ?  696  PRO A N   1 
ATOM   5310 C  CA  . PRO A 1 696 ? 20.63971  0.30492   43.71896  1.000 37.22196  ?  696  PRO A CA  1 
ATOM   5311 C  C   . PRO A 1 696 ? 20.50181  -0.33480  45.09516  1.000 40.14995  ?  696  PRO A C   1 
ATOM   5312 O  O   . PRO A 1 696 ? 21.38579  -0.25200  45.94377  1.000 38.86263  ?  696  PRO A O   1 
ATOM   5313 C  CB  . PRO A 1 696 ? 21.04216  -0.74533  42.67534  1.000 33.36054  ?  696  PRO A CB  1 
ATOM   5314 C  CG  . PRO A 1 696 ? 22.55073  -0.76818  42.76074  1.000 31.37739  ?  696  PRO A CG  1 
ATOM   5315 C  CD  . PRO A 1 696 ? 22.95082  0.69279   43.02276  1.000 40.30711  ?  696  PRO A CD  1 
ATOM   5316 N  N   . LEU A 1 697 ? 19.36032  -0.98517  45.30084  1.000 37.85031  ?  697  LEU A N   1 
ATOM   5317 C  CA  . LEU A 1 697 ? 19.21004  -1.85201  46.45683  1.000 39.45832  ?  697  LEU A CA  1 
ATOM   5318 C  C   . LEU A 1 697 ? 20.01453  -3.12199  46.23371  1.000 42.78144  ?  697  LEU A C   1 
ATOM   5319 O  O   . LEU A 1 697 ? 20.03458  -3.67758  45.13105  1.000 39.70892  ?  697  LEU A O   1 
ATOM   5320 C  CB  . LEU A 1 697 ? 17.73267  -2.19118  46.70998  1.000 35.57938  ?  697  LEU A CB  1 
ATOM   5321 C  CG  . LEU A 1 697 ? 16.85670  -0.98238  47.04938  1.000 40.26532  ?  697  LEU A CG  1 
ATOM   5322 C  CD1 . LEU A 1 697 ? 15.35137  -1.31685  47.02037  1.000 31.94634  ?  697  LEU A CD1 1 
ATOM   5323 C  CD2 . LEU A 1 697 ? 17.28660  -0.40849  48.41823  1.000 38.27138  ?  697  LEU A CD2 1 
ATOM   5324 N  N   . ALA A 1 698 ? 20.68602  -3.57969  47.28683  1.000 45.45618  ?  698  ALA A N   1 
ATOM   5325 C  CA  . ALA A 1 698 ? 21.51603  -4.77419  47.21667  1.000 48.51267  ?  698  ALA A CA  1 
ATOM   5326 C  C   . ALA A 1 698 ? 21.33960  -5.57676  48.49223  1.000 50.20825  ?  698  ALA A C   1 
ATOM   5327 O  O   . ALA A 1 698 ? 20.72568  -5.11834  49.46032  1.000 52.15387  ?  698  ALA A O   1 
ATOM   5328 C  CB  . ALA A 1 698 ? 23.00015  -4.43189  47.00375  1.000 50.19179  ?  698  ALA A CB  1 
ATOM   5329 N  N   . HIS A 1 699 ? 21.88955  -6.79030  48.47581  1.000 52.37768  ?  699  HIS A N   1 
ATOM   5330 C  CA  . HIS A 1 699 ? 21.81222  -7.71707  49.59302  1.000 59.77157  ?  699  HIS A CA  1 
ATOM   5331 C  C   . HIS A 1 699 ? 23.18472  -8.33254  49.84958  1.000 60.21524  ?  699  HIS A C   1 
ATOM   5332 O  O   . HIS A 1 699 ? 24.00107  -8.46826  48.93328  1.000 58.05240  ?  699  HIS A O   1 
ATOM   5333 C  CB  . HIS A 1 699 ? 20.75858  -8.80664  49.32708  1.000 55.25552  ?  699  HIS A CB  1 
ATOM   5334 C  CG  . HIS A 1 699 ? 21.05570  -9.67101  48.13733  1.000 59.01148  ?  699  HIS A CG  1 
ATOM   5335 N  ND1 . HIS A 1 699 ? 22.32058  -10.12486 47.83115  1.000 58.42971  ?  699  HIS A ND1 1 
ATOM   5336 C  CD2 . HIS A 1 699 ? 20.23856  -10.17382 47.18110  1.000 62.24696  ?  699  HIS A CD2 1 
ATOM   5337 C  CE1 . HIS A 1 699 ? 22.27183  -10.86602 46.73944  1.000 60.50661  ?  699  HIS A CE1 1 
ATOM   5338 N  NE2 . HIS A 1 699 ? 21.01964  -10.91039 46.32295  1.000 65.72507  ?  699  HIS A NE2 1 
ATOM   5339 N  N   . TRP A 1 700 ? 23.42630  -8.71110  51.10125  1.000 58.93289  ?  700  TRP A N   1 
ATOM   5340 C  CA  . TRP A 1 700 ? 24.69727  -9.31348  51.50362  1.000 65.41662  ?  700  TRP A CA  1 
ATOM   5341 C  C   . TRP A 1 700 ? 24.58378  -10.82628 51.65024  1.000 65.65323  ?  700  TRP A C   1 
ATOM   5342 O  O   . TRP A 1 700 ? 24.77062  -11.56386 50.68287  1.000 64.99840  ?  700  TRP A O   1 
ATOM   5343 C  CB  . TRP A 1 700 ? 25.18080  -8.69970  52.80744  1.000 64.25681  ?  700  TRP A CB  1 
ATOM   5344 C  CG  . TRP A 1 700 ? 25.56265  -7.27412  52.64656  1.000 66.82881  ?  700  TRP A CG  1 
ATOM   5345 C  CD1 . TRP A 1 700 ? 26.82209  -6.78245  52.53555  1.000 63.80472  ?  700  TRP A CD1 1 
ATOM   5346 C  CD2 . TRP A 1 700 ? 24.67794  -6.14789  52.54933  1.000 69.73746  ?  700  TRP A CD2 1 
ATOM   5347 N  NE1 . TRP A 1 700 ? 26.78671  -5.41833  52.38933  1.000 74.51877  ?  700  TRP A NE1 1 
ATOM   5348 C  CE2 . TRP A 1 700 ? 25.48099  -5.00102  52.39358  1.000 72.45356  ?  700  TRP A CE2 1 
ATOM   5349 C  CE3 . TRP A 1 700 ? 23.28906  -5.99611  52.58614  1.000 66.83037  ?  700  TRP A CE3 1 
ATOM   5350 C  CZ2 . TRP A 1 700 ? 24.94269  -3.71526  52.27265  1.000 62.19203  ?  700  TRP A CZ2 1 
ATOM   5351 C  CZ3 . TRP A 1 700 ? 22.75787  -4.71415  52.46449  1.000 64.55102  ?  700  TRP A CZ3 1 
ATOM   5352 C  CH2 . TRP A 1 700 ? 23.58708  -3.59458  52.31100  1.000 59.42825  ?  700  TRP A CH2 1 
ATOM   5353 N  N   . SER A 1 705 ? 30.52653  -8.91696  50.62993  1.000 67.69605  ?  705  SER A N   1 
ATOM   5354 C  CA  . SER A 1 705 ? 30.36344  -8.73399  49.18841  1.000 68.38258  ?  705  SER A CA  1 
ATOM   5355 C  C   . SER A 1 705 ? 28.92674  -8.37057  48.82134  1.000 66.21544  ?  705  SER A C   1 
ATOM   5356 O  O   . SER A 1 705 ? 28.04312  -9.22912  48.83734  1.000 66.50060  ?  705  SER A O   1 
ATOM   5357 C  CB  . SER A 1 705 ? 30.77788  -9.99789  48.43254  1.000 69.92653  ?  705  SER A CB  1 
ATOM   5358 O  OG  . SER A 1 705 ? 30.68383  -9.80754  47.02869  1.000 70.04979  ?  705  SER A OG  1 
ATOM   5359 N  N   . PRO A 1 706 ? 28.69476  -7.09824  48.49270  1.000 65.04538  ?  706  PRO A N   1 
ATOM   5360 C  CA  . PRO A 1 706 ? 27.33867  -6.65807  48.12311  1.000 65.42666  ?  706  PRO A CA  1 
ATOM   5361 C  C   . PRO A 1 706 ? 26.96009  -7.10421  46.71435  1.000 58.99992  ?  706  PRO A C   1 
ATOM   5362 O  O   . PRO A 1 706 ? 27.71584  -6.91770  45.75812  1.000 60.50640  ?  706  PRO A O   1 
ATOM   5363 C  CB  . PRO A 1 706 ? 27.42017  -5.12947  48.21802  1.000 61.57697  ?  706  PRO A CB  1 
ATOM   5364 C  CG  . PRO A 1 706 ? 28.86384  -4.81006  48.02455  1.000 61.68495  ?  706  PRO A CG  1 
ATOM   5365 C  CD  . PRO A 1 706 ? 29.65413  -5.98335  48.54628  1.000 63.38453  ?  706  PRO A CD  1 
ATOM   5366 N  N   . GLN A 1 707 ? 25.77051  -7.67310  46.58684  1.000 54.39729  ?  707  GLN A N   1 
ATOM   5367 C  CA  . GLN A 1 707 ? 25.22444  -8.05443  45.29514  1.000 55.24528  ?  707  GLN A CA  1 
ATOM   5368 C  C   . GLN A 1 707 ? 23.91859  -7.30952  45.04389  1.000 52.66586  ?  707  GLN A C   1 
ATOM   5369 O  O   . GLN A 1 707 ? 22.98186  -7.40159  45.84910  1.000 49.27934  ?  707  GLN A O   1 
ATOM   5370 C  CB  . GLN A 1 707 ? 24.99767  -9.55999  45.24569  1.000 54.41909  ?  707  GLN A CB  1 
ATOM   5371 C  CG  . GLN A 1 707 ? 26.15523  -10.32125 44.65042  1.000 61.70572  ?  707  GLN A CG  1 
ATOM   5372 C  CD  . GLN A 1 707 ? 25.80840  -11.77436 44.39788  1.000 66.16967  ?  707  GLN A CD  1 
ATOM   5373 O  OE1 . GLN A 1 707 ? 24.72799  -12.24263 44.77905  1.000 62.78268  ?  707  GLN A OE1 1 
ATOM   5374 N  NE2 . GLN A 1 707 ? 26.72549  -12.50190 43.75671  1.000 69.68380  ?  707  GLN A NE2 1 
ATOM   5375 N  N   . ILE A 1 708 ? 23.85281  -6.59459  43.91477  1.000 46.97959  ?  708  ILE A N   1 
ATOM   5376 C  CA  . ILE A 1 708 ? 22.62436  -5.90536  43.52731  1.000 44.28950  ?  708  ILE A CA  1 
ATOM   5377 C  C   . ILE A 1 708 ? 21.48972  -6.90676  43.32221  1.000 43.44059  ?  708  ILE A C   1 
ATOM   5378 O  O   . ILE A 1 708 ? 21.69536  -8.03060  42.83976  1.000 48.31424  ?  708  ILE A O   1 
ATOM   5379 C  CB  . ILE A 1 708 ? 22.87502  -5.06675  42.26290  1.000 44.05249  ?  708  ILE A CB  1 
ATOM   5380 C  CG1 . ILE A 1 708 ? 24.10813  -4.18264  42.46961  1.000 39.85234  ?  708  ILE A CG1 1 
ATOM   5381 C  CG2 . ILE A 1 708 ? 21.63440  -4.22447  41.88557  1.000 35.72083  ?  708  ILE A CG2 1 
ATOM   5382 C  CD1 . ILE A 1 708 ? 24.58359  -3.48652  41.18863  1.000 38.22918  ?  708  ILE A CD1 1 
ATOM   5383 N  N   . VAL A 1 709 ? 20.28219  -6.51332  43.72882  1.000 39.81570  ?  709  VAL A N   1 
ATOM   5384 C  CA  . VAL A 1 709 ? 19.11492  -7.38371  43.60132  1.000 46.42047  ?  709  VAL A CA  1 
ATOM   5385 C  C   . VAL A 1 709 ? 18.80854  -7.61568  42.12196  1.000 41.89313  ?  709  VAL A C   1 
ATOM   5386 O  O   . VAL A 1 709 ? 18.77694  -6.67189  41.32981  1.000 40.84291  ?  709  VAL A O   1 
ATOM   5387 C  CB  . VAL A 1 709 ? 17.91289  -6.76378  44.34136  1.000 43.14917  ?  709  VAL A CB  1 
ATOM   5388 C  CG1 . VAL A 1 709 ? 16.66729  -7.64075  44.21712  1.000 35.93359  ?  709  VAL A CG1 1 
ATOM   5389 C  CG2 . VAL A 1 709 ? 18.24340  -6.53459  45.82014  1.000 41.32315  ?  709  VAL A CG2 1 
ATOM   5390 N  N   . GLU A 1 710 ? 18.59556  -8.87744  41.73626  1.000 44.58813  ?  710  GLU A N   1 
ATOM   5391 C  CA  . GLU A 1 710 ? 18.20295  -9.17946  40.36072  1.000 43.60087  ?  710  GLU A CA  1 
ATOM   5392 C  C   . GLU A 1 710 ? 16.82099  -8.60325  40.05430  1.000 44.48733  ?  710  GLU A C   1 
ATOM   5393 O  O   . GLU A 1 710 ? 15.94257  -8.52963  40.92009  1.000 43.02185  ?  710  GLU A O   1 
ATOM   5394 C  CB  . GLU A 1 710 ? 18.18098  -10.69208 40.10894  1.000 48.20664  ?  710  GLU A CB  1 
ATOM   5395 C  CG  . GLU A 1 710 ? 19.53014  -11.37939 40.14005  1.000 52.33652  ?  710  GLU A CG  1 
ATOM   5396 C  CD  . GLU A 1 710 ? 20.49754  -10.79367 39.14496  1.000 57.88403  ?  710  GLU A CD  1 
ATOM   5397 O  OE1 . GLU A 1 710 ? 20.08196  -10.51440 37.99552  1.000 60.43324  ?  710  GLU A OE1 1 
ATOM   5398 O  OE2 . GLU A 1 710 ? 21.67716  -10.60524 39.51680  1.000 66.54185  -1 710  GLU A OE2 1 
ATOM   5399 N  N   . ALA A 1 711 ? 16.61409  -8.23031  38.79396  1.000 38.82258  ?  711  ALA A N   1 
ATOM   5400 C  CA  . ALA A 1 711 ? 15.40772  -7.48173  38.45629  1.000 41.75255  ?  711  ALA A CA  1 
ATOM   5401 C  C   . ALA A 1 711 ? 14.15259  -8.30763  38.67127  1.000 41.17568  ?  711  ALA A C   1 
ATOM   5402 O  O   . ALA A 1 711 ? 13.11488  -7.76490  39.06073  1.000 38.61534  ?  711  ALA A O   1 
ATOM   5403 C  CB  . ALA A 1 711 ? 15.47441  -6.97668  37.01287  1.000 42.68987  ?  711  ALA A CB  1 
ATOM   5404 N  N   . ASN A 1 712 ? 14.21827  -9.61096  38.45873  1.000 39.73466  ?  712  ASN A N   1 
ATOM   5405 C  CA  . ASN A 1 712 ? 13.03269  -10.41760 38.65757  1.000 39.72489  ?  712  ASN A CA  1 
ATOM   5406 C  C   . ASN A 1 712 ? 12.94799  -10.99463 40.07047  1.000 44.46510  ?  712  ASN A C   1 
ATOM   5407 O  O   . ASN A 1 712 ? 12.13410  -11.88956 40.30604  1.000 45.99195  ?  712  ASN A O   1 
ATOM   5408 C  CB  . ASN A 1 712 ? 12.97545  -11.54932 37.61638  1.000 44.60064  ?  712  ASN A CB  1 
ATOM   5409 C  CG  . ASN A 1 712 ? 14.19283  -12.45997 37.66516  1.000 46.07499  ?  712  ASN A CG  1 
ATOM   5410 O  OD1 . ASN A 1 712 ? 15.30958  -12.02219 37.97030  1.000 46.70488  ?  712  ASN A OD1 1 
ATOM   5411 N  ND2 . ASN A 1 712 ? 13.98220  -13.73742 37.36553  1.000 52.10688  ?  712  ASN A ND2 1 
ATOM   5412 N  N   . GLU A 1 713 ? 13.78793  -10.53258 41.00032  1.000 44.96452  ?  713  GLU A N   1 
ATOM   5413 C  CA  . GLU A 1 713 ? 13.73627  -10.97005 42.39289  1.000 46.59286  ?  713  GLU A CA  1 
ATOM   5414 C  C   . GLU A 1 713 ? 13.33191  -9.85604  43.35459  1.000 42.90269  ?  713  GLU A C   1 
ATOM   5415 O  O   . GLU A 1 713 ? 13.14838  -10.11307 44.56215  1.000 41.10050  ?  713  GLU A O   1 
ATOM   5416 C  CB  . GLU A 1 713 ? 15.08557  -11.57094 42.80343  1.000 45.04438  ?  713  GLU A CB  1 
ATOM   5417 C  CG  . GLU A 1 713 ? 15.31016  -12.96393 42.21905  1.000 49.72001  ?  713  GLU A CG  1 
ATOM   5418 C  CD  . GLU A 1 713 ? 16.75265  -13.21967 41.80173  1.000 60.29985  ?  713  GLU A CD  1 
ATOM   5419 O  OE1 . GLU A 1 713 ? 17.66216  -13.07145 42.65368  1.000 60.05453  ?  713  GLU A OE1 1 
ATOM   5420 O  OE2 . GLU A 1 713 ? 16.97955  -13.56182 40.60952  1.000 66.77487  -1 713  GLU A OE2 1 
ATOM   5421 N  N   . LEU A 1 714 ? 13.12064  -8.64341  42.83272  1.000 41.10691  ?  714  LEU A N   1 
ATOM   5422 C  CA  . LEU A 1 714 ? 12.79576  -7.49093  43.66566  1.000 40.53203  ?  714  LEU A CA  1 
ATOM   5423 C  C   . LEU A 1 714 ? 11.58312  -7.75765  44.55064  1.000 40.18992  ?  714  LEU A C   1 
ATOM   5424 O  O   . LEU A 1 714 ? 11.60417  -7.47491  45.75459  1.000 40.51143  ?  714  LEU A O   1 
ATOM   5425 C  CB  . LEU A 1 714 ? 12.55104  -6.27947  42.77261  1.000 39.38865  ?  714  LEU A CB  1 
ATOM   5426 C  CG  . LEU A 1 714 ? 13.84094  -5.51117  42.49714  1.000 41.35973  ?  714  LEU A CG  1 
ATOM   5427 C  CD1 . LEU A 1 714 ? 13.62095  -4.45054  41.42120  1.000 36.33248  ?  714  LEU A CD1 1 
ATOM   5428 C  CD2 . LEU A 1 714 ? 14.35974  -4.90309  43.79305  1.000 36.11539  ?  714  LEU A CD2 1 
ATOM   5429 N  N   . ASP A 1 715 ? 10.52219  -8.31846  43.97455  1.000 41.13887  ?  715  ASP A N   1 
ATOM   5430 C  CA  . ASP A 1 715 ? 9.30678   -8.55214  44.74643  1.000 43.14704  ?  715  ASP A CA  1 
ATOM   5431 C  C   . ASP A 1 715 ? 9.60536   -9.41457  45.96073  1.000 46.07700  ?  715  ASP A C   1 
ATOM   5432 O  O   . ASP A 1 715 ? 9.28369   -9.03567  47.10281  1.000 44.07936  ?  715  ASP A O   1 
ATOM   5433 C  CB  . ASP A 1 715 ? 8.23707   -9.19613  43.86227  1.000 40.27869  ?  715  ASP A CB  1 
ATOM   5434 C  CG  . ASP A 1 715 ? 7.65843   -8.22639  42.84826  1.000 53.03447  ?  715  ASP A CG  1 
ATOM   5435 O  OD1 . ASP A 1 715 ? 7.75573   -6.99037  43.05957  1.000 54.20033  -1 715  ASP A OD1 1 
ATOM   5436 O  OD2 . ASP A 1 715 ? 7.10956   -8.69286  41.82597  1.000 62.12676  -1 715  ASP A OD2 1 
ATOM   5437 N  N   . ASP A 1 716 ? 10.32165  -10.53162 45.74910  1.000 44.25573  ?  716  ASP A N   1 
ATOM   5438 C  CA  . ASP A 1 716 ? 10.64000  -11.39160 46.88477  1.000 43.35096  ?  716  ASP A CA  1 
ATOM   5439 C  C   . ASP A 1 716 ? 11.45458  -10.61769 47.91017  1.000 40.97955  ?  716  ASP A C   1 
ATOM   5440 O  O   . ASP A 1 716 ? 11.16058  -10.65615 49.11693  1.000 39.36704  ?  716  ASP A O   1 
ATOM   5441 C  CB  . ASP A 1 716 ? 11.38050  -12.63445 46.39580  1.000 50.13601  ?  716  ASP A CB  1 
ATOM   5442 C  CG  . ASP A 1 716 ? 11.54879  -13.67997 47.47098  1.000 60.47480  ?  716  ASP A CG  1 
ATOM   5443 O  OD1 . ASP A 1 716 ? 10.69096  -14.59118 47.53601  1.000 72.93329  -1 716  ASP A OD1 1 
ATOM   5444 O  OD2 . ASP A 1 716 ? 12.54437  -13.61077 48.23529  1.000 60.56739  -1 716  ASP A OD2 1 
ATOM   5445 N  N   . PHE A 1 717 ? 12.42604  -9.83420  47.42272  1.000 40.05128  ?  717  PHE A N   1 
ATOM   5446 C  CA  . PHE A 1 717 ? 13.25862  -8.99734  48.28371  1.000 36.56191  ?  717  PHE A CA  1 
ATOM   5447 C  C   . PHE A 1 717 ? 12.39516  -8.08936  49.14969  1.000 41.81397  ?  717  PHE A C   1 
ATOM   5448 O  O   . PHE A 1 717 ? 12.53000  -8.07433  50.38144  1.000 42.70731  ?  717  PHE A O   1 
ATOM   5449 C  CB  . PHE A 1 717 ? 14.21219  -8.18161  47.40993  1.000 36.48513  ?  717  PHE A CB  1 
ATOM   5450 C  CG  . PHE A 1 717 ? 15.15328  -7.29709  48.16414  1.000 34.79739  ?  717  PHE A CG  1 
ATOM   5451 C  CD1 . PHE A 1 717 ? 16.35357  -7.79194  48.63285  1.000 40.57772  ?  717  PHE A CD1 1 
ATOM   5452 C  CD2 . PHE A 1 717 ? 14.84927  -5.96374  48.37762  1.000 35.36211  ?  717  PHE A CD2 1 
ATOM   5453 C  CE1 . PHE A 1 717 ? 17.23834  -6.99216  49.29962  1.000 41.53341  ?  717  PHE A CE1 1 
ATOM   5454 C  CE2 . PHE A 1 717 ? 15.72159  -5.14828  49.04533  1.000 38.22997  ?  717  PHE A CE2 1 
ATOM   5455 C  CZ  . PHE A 1 717 ? 16.92550  -5.66133  49.51388  1.000 49.50802  ?  717  PHE A CZ  1 
ATOM   5456 N  N   . PHE A 1 718 ? 11.44772  -7.37434  48.52500  1.000 39.61057  ?  718  PHE A N   1 
ATOM   5457 C  CA  . PHE A 1 718 ? 10.63738  -6.44148  49.29761  1.000 38.86484  ?  718  PHE A CA  1 
ATOM   5458 C  C   . PHE A 1 718 ? 9.77020   -7.17824  50.30469  1.000 37.91937  ?  718  PHE A C   1 
ATOM   5459 O  O   . PHE A 1 718 ? 9.49759   -6.65861  51.39059  1.000 35.04038  ?  718  PHE A O   1 
ATOM   5460 C  CB  . PHE A 1 718 ? 9.77174   -5.57913  48.36767  1.000 37.22462  ?  718  PHE A CB  1 
ATOM   5461 C  CG  . PHE A 1 718 ? 10.47104  -4.34203  47.86980  1.000 32.48169  ?  718  PHE A CG  1 
ATOM   5462 C  CD1 . PHE A 1 718 ? 11.47527  -4.43819  46.92716  1.000 36.04495  ?  718  PHE A CD1 1 
ATOM   5463 C  CD2 . PHE A 1 718 ? 10.13814  -3.09148  48.34851  1.000 40.16469  ?  718  PHE A CD2 1 
ATOM   5464 C  CE1 . PHE A 1 718 ? 12.13327  -3.29873  46.46929  1.000 37.63692  ?  718  PHE A CE1 1 
ATOM   5465 C  CE2 . PHE A 1 718 ? 10.78655  -1.95522  47.88484  1.000 36.09097  ?  718  PHE A CE2 1 
ATOM   5466 C  CZ  . PHE A 1 718 ? 11.78305  -2.06652  46.94100  1.000 35.72220  ?  718  PHE A CZ  1 
ATOM   5467 N  N   . ARG A 1 719 ? 9.34542   -8.39781  49.97524  1.000 43.40710  ?  719  ARG A N   1 
ATOM   5468 C  CA  . ARG A 1 719 ? 8.53551   -9.13455  50.92624  1.000 40.13877  ?  719  ARG A CA  1 
ATOM   5469 C  C   . ARG A 1 719 ? 9.37019   -9.58279  52.11017  1.000 45.01739  ?  719  ARG A C   1 
ATOM   5470 O  O   . ARG A 1 719 ? 8.87968   -9.60164  53.24729  1.000 43.77827  ?  719  ARG A O   1 
ATOM   5471 C  CB  . ARG A 1 719 ? 7.87913   -10.31226 50.23577  1.000 45.15862  ?  719  ARG A CB  1 
ATOM   5472 C  CG  . ARG A 1 719 ? 6.47091   -9.99957  49.90433  1.000 49.56293  ?  719  ARG A CG  1 
ATOM   5473 C  CD  . ARG A 1 719 ? 5.97981   -10.79073 48.72478  1.000 55.36827  ?  719  ARG A CD  1 
ATOM   5474 N  NE  . ARG A 1 719 ? 5.71629   -12.19053 49.03940  1.000 60.50585  ?  719  ARG A NE  1 
ATOM   5475 C  CZ  . ARG A 1 719 ? 4.89050   -12.62847 49.98185  1.000 62.80252  ?  719  ARG A CZ  1 
ATOM   5476 N  NH1 . ARG A 1 719 ? 4.27164   -11.79875 50.81139  1.000 63.40758  ?  719  ARG A NH1 1 
ATOM   5477 N  NH2 . ARG A 1 719 ? 4.67586   -13.93670 50.09283  1.000 68.86443  ?  719  ARG A NH2 1 
ATOM   5478 N  N   . ARG A 1 720 ? 10.64649  -9.91596  51.87423  1.000 46.46981  ?  720  ARG A N   1 
ATOM   5479 C  CA  . ARG A 1 720 ? 11.44947  -10.46250 52.96478  1.000 46.29942  ?  720  ARG A CA  1 
ATOM   5480 C  C   . ARG A 1 720 ? 11.80126  -9.38509  53.97451  1.000 43.81525  ?  720  ARG A C   1 
ATOM   5481 O  O   . ARG A 1 720 ? 11.82226  -9.63987  55.18302  1.000 46.50009  ?  720  ARG A O   1 
ATOM   5482 C  CB  . ARG A 1 720 ? 12.71306  -11.12498 52.42062  1.000 47.02750  ?  720  ARG A CB  1 
ATOM   5483 C  CG  . ARG A 1 720 ? 12.51140  -12.58696 52.10181  1.000 46.85355  ?  720  ARG A CG  1 
ATOM   5484 C  CD  . ARG A 1 720 ? 13.67171  -13.13129 51.28038  1.000 56.99517  ?  720  ARG A CD  1 
ATOM   5485 N  NE  . ARG A 1 720 ? 14.92200  -12.43973 51.57493  1.000 62.50513  ?  720  ARG A NE  1 
ATOM   5486 C  CZ  . ARG A 1 720 ? 15.70771  -11.89056 50.65538  1.000 61.82904  ?  720  ARG A CZ  1 
ATOM   5487 N  NH1 . ARG A 1 720 ? 15.35725  -11.86001 49.37901  1.000 50.52004  ?  720  ARG A NH1 1 
ATOM   5488 N  NH2 . ARG A 1 720 ? 16.86785  -11.34569 51.02819  1.000 63.14078  ?  720  ARG A NH2 1 
ATOM   5489 N  N   . HIS A 1 721 ? 12.06960  -8.17737  53.50253  1.000 39.74544  ?  721  HIS A N   1 
ATOM   5490 C  CA  . HIS A 1 721 ? 12.49708  -7.11395  54.39022  1.000 42.23282  ?  721  HIS A CA  1 
ATOM   5491 C  C   . HIS A 1 721 ? 11.34605  -6.29162  54.95715  1.000 42.91017  ?  721  HIS A C   1 
ATOM   5492 O  O   . HIS A 1 721 ? 11.56240  -5.54887  55.92235  1.000 41.12866  ?  721  HIS A O   1 
ATOM   5493 C  CB  . HIS A 1 721 ? 13.47525  -6.18777  53.66031  1.000 40.36184  ?  721  HIS A CB  1 
ATOM   5494 C  CG  . HIS A 1 721 ? 14.84553  -6.77202  53.49039  1.000 49.72832  ?  721  HIS A CG  1 
ATOM   5495 N  ND1 . HIS A 1 721 ? 15.12476  -7.76588  52.57363  1.000 47.78394  ?  721  HIS A ND1 1 
ATOM   5496 C  CD2 . HIS A 1 721 ? 16.01120  -6.51363  54.13356  1.000 49.48390  ?  721  HIS A CD2 1 
ATOM   5497 C  CE1 . HIS A 1 721 ? 16.40441  -8.08457  52.65370  1.000 51.19605  ?  721  HIS A CE1 1 
ATOM   5498 N  NE2 . HIS A 1 721 ? 16.96403  -7.34050  53.59253  1.000 50.65611  ?  721  HIS A NE2 1 
ATOM   5499 N  N   . LEU A 1 722 ? 10.13698  -6.39142  54.39267  1.000 40.92410  ?  722  LEU A N   1 
ATOM   5500 C  CA  . LEU A 1 722 ? 9.05241   -5.50144  54.79143  1.000 40.19268  ?  722  LEU A CA  1 
ATOM   5501 C  C   . LEU A 1 722 ? 7.83051   -6.19111  55.38128  1.000 37.84420  ?  722  LEU A C   1 
ATOM   5502 O  O   . LEU A 1 722 ? 7.09693   -5.54732  56.13697  1.000 39.74066  ?  722  LEU A O   1 
ATOM   5503 C  CB  . LEU A 1 722 ? 8.58709   -4.63641  53.61091  1.000 37.16506  ?  722  LEU A CB  1 
ATOM   5504 C  CG  . LEU A 1 722 ? 9.59557   -3.67620  52.99154  1.000 37.75086  ?  722  LEU A CG  1 
ATOM   5505 C  CD1 . LEU A 1 722 ? 8.88706   -2.80752  51.96320  1.000 40.50133  ?  722  LEU A CD1 1 
ATOM   5506 C  CD2 . LEU A 1 722 ? 10.24542  -2.82165  54.05356  1.000 35.53073  ?  722  LEU A CD2 1 
ATOM   5507 N  N   . ASP A 1 723 ? 7.57561   -7.45367  55.06892  1.000 40.58428  ?  723  ASP A N   1 
ATOM   5508 C  CA  . ASP A 1 723 ? 6.39150   -8.09836  55.61695  1.000 41.70198  ?  723  ASP A CA  1 
ATOM   5509 C  C   . ASP A 1 723 ? 6.49696   -8.16683  57.13771  1.000 46.41171  ?  723  ASP A C   1 
ATOM   5510 O  O   . ASP A 1 723 ? 7.57755   -8.37982  57.69636  1.000 43.56752  ?  723  ASP A O   1 
ATOM   5511 C  CB  . ASP A 1 723 ? 6.21517   -9.50030  55.01740  1.000 50.00699  ?  723  ASP A CB  1 
ATOM   5512 C  CG  . ASP A 1 723 ? 5.54163   -9.48160  53.62673  1.000 53.63347  ?  723  ASP A CG  1 
ATOM   5513 O  OD1 . ASP A 1 723 ? 5.39192   -8.38749  53.01325  1.000 46.78888  ?  723  ASP A OD1 1 
ATOM   5514 O  OD2 . ASP A 1 723 ? 5.15953   -10.58099 53.15050  1.000 57.83063  -1 723  ASP A OD2 1 
ATOM   5515 N  N   . GLY A 1 724 ? 5.37144   -7.94206  57.81440  1.000 43.20878  ?  724  GLY A N   1 
ATOM   5516 C  CA  . GLY A 1 724 ? 5.38856   -7.91863  59.26415  1.000 41.37890  ?  724  GLY A CA  1 
ATOM   5517 C  C   . GLY A 1 724 ? 6.01616   -6.69420  59.89273  1.000 42.97561  ?  724  GLY A C   1 
ATOM   5518 O  O   . GLY A 1 724 ? 6.22630   -6.68873  61.10596  1.000 46.01617  ?  724  GLY A O   1 
ATOM   5519 N  N   . VAL A 1 725 ? 6.31262   -5.65487  59.11370  1.000 39.85624  ?  725  VAL A N   1 
ATOM   5520 C  CA  . VAL A 1 725 ? 6.94105   -4.42634  59.59585  1.000 36.27342  ?  725  VAL A CA  1 
ATOM   5521 C  C   . VAL A 1 725 ? 5.97058   -3.26190  59.39457  1.000 41.75621  ?  725  VAL A C   1 
ATOM   5522 O  O   . VAL A 1 725 ? 5.32172   -3.16008  58.34774  1.000 36.91794  ?  725  VAL A O   1 
ATOM   5523 C  CB  . VAL A 1 725 ? 8.26590   -4.14970  58.84920  1.000 41.00200  ?  725  VAL A CB  1 
ATOM   5524 C  CG1 . VAL A 1 725 ? 8.88731   -2.83605  59.28911  1.000 34.56344  ?  725  VAL A CG1 1 
ATOM   5525 C  CG2 . VAL A 1 725 ? 9.24153   -5.31440  58.99468  1.000 37.98204  ?  725  VAL A CG2 1 
ATOM   5526 N  N   . GLU A 1 726 ? 5.86162   -2.38716  60.39744  1.000 36.55678  ?  726  GLU A N   1 
ATOM   5527 C  CA  . GLU A 1 726 ? 5.05377   -1.19085  60.24229  1.000 35.22373  ?  726  GLU A CA  1 
ATOM   5528 C  C   . GLU A 1 726 ? 5.58174   -0.31652  59.09746  1.000 41.36503  ?  726  GLU A C   1 
ATOM   5529 O  O   . GLU A 1 726 ? 6.79815   -0.13740  58.92974  1.000 35.31751  ?  726  GLU A O   1 
ATOM   5530 C  CB  . GLU A 1 726 ? 5.02699   -0.40127  61.55323  1.000 41.01984  ?  726  GLU A CB  1 
ATOM   5531 C  CG  . GLU A 1 726 ? 4.17831   -1.06476  62.65351  1.000 42.32595  ?  726  GLU A CG  1 
ATOM   5532 C  CD  . GLU A 1 726 ? 2.68539   -1.08151  62.31059  1.000 40.42443  ?  726  GLU A CD  1 
ATOM   5533 O  OE1 . GLU A 1 726 ? 2.06367   0.00952   62.28655  1.000 40.86392  ?  726  GLU A OE1 1 
ATOM   5534 O  OE2 . GLU A 1 726 ? 2.14299   -2.18637  62.04841  1.000 40.46983  -1 726  GLU A OE2 1 
ATOM   5535 N  N   . VAL A 1 727 ? 4.64482   0.24992   58.32197  1.000 34.66049  ?  727  VAL A N   1 
ATOM   5536 C  CA  . VAL A 1 727 ? 4.98461   1.07413   57.15901  1.000 35.74114  ?  727  VAL A CA  1 
ATOM   5537 C  C   . VAL A 1 727 ? 5.89963   2.22081   57.56373  1.000 39.90016  ?  727  VAL A C   1 
ATOM   5538 O  O   . VAL A 1 727 ? 6.79826   2.61284   56.80675  1.000 37.24620  ?  727  VAL A O   1 
ATOM   5539 C  CB  . VAL A 1 727 ? 3.69025   1.59175   56.47982  1.000 33.51491  ?  727  VAL A CB  1 
ATOM   5540 C  CG1 . VAL A 1 727 ? 3.97488   2.83064   55.62326  1.000 36.10626  ?  727  VAL A CG1 1 
ATOM   5541 C  CG2 . VAL A 1 727 ? 3.03709   0.49548   55.63857  1.000 34.32729  ?  727  VAL A CG2 1 
ATOM   5542 N  N   . SER A 1 728 ? 5.70425   2.75907   58.77448  1.000 36.98041  ?  728  SER A N   1 
ATOM   5543 C  CA  . SER A 1 728 ? 6.48376   3.89894   59.25175  1.000 39.45550  ?  728  SER A CA  1 
ATOM   5544 C  C   . SER A 1 728 ? 7.97790   3.61218   59.30500  1.000 41.94058  ?  728  SER A C   1 
ATOM   5545 O  O   . SER A 1 728 ? 8.77103   4.55788   59.35031  1.000 41.63633  ?  728  SER A O   1 
ATOM   5546 C  CB  . SER A 1 728 ? 5.99463   4.29205   60.64015  1.000 35.89293  ?  728  SER A CB  1 
ATOM   5547 O  OG  . SER A 1 728 ? 6.11098   3.15411   61.48713  1.000 39.19713  ?  728  SER A OG  1 
ATOM   5548 N  N   . GLU A 1 729 ? 8.37070   2.33374   59.35334  1.000 39.02010  ?  729  GLU A N   1 
ATOM   5549 C  CA  . GLU A 1 729 ? 9.76537   1.89689   59.37121  1.000 43.02008  ?  729  GLU A CA  1 
ATOM   5550 C  C   . GLU A 1 729 ? 10.31182  1.50573   57.99669  1.000 45.65528  ?  729  GLU A C   1 
ATOM   5551 O  O   . GLU A 1 729 ? 11.53877  1.35379   57.85279  1.000 44.02395  ?  729  GLU A O   1 
ATOM   5552 C  CB  . GLU A 1 729 ? 9.92103   0.68710   60.30781  1.000 43.84083  ?  729  GLU A CB  1 
ATOM   5553 C  CG  . GLU A 1 729 ? 10.17471  1.07081   61.76701  1.000 55.34460  ?  729  GLU A CG  1 
ATOM   5554 C  CD  . GLU A 1 729 ? 9.46536   0.15117   62.74178  1.000 64.31713  ?  729  GLU A CD  1 
ATOM   5555 O  OE1 . GLU A 1 729 ? 9.56089   -1.09033  62.58217  1.000 67.43662  ?  729  GLU A OE1 1 
ATOM   5556 O  OE2 . GLU A 1 729 ? 8.78314   0.67256   63.65325  1.000 77.18696  -1 729  GLU A OE2 1 
ATOM   5557 N  N   . TRP A 1 730 ? 9.44376   1.34710   56.98999  1.000 40.46584  ?  730  TRP A N   1 
ATOM   5558 C  CA  . TRP A 1 730 ? 9.86461   0.72617   55.73331  1.000 40.84312  ?  730  TRP A CA  1 
ATOM   5559 C  C   . TRP A 1 730 ? 11.07773  1.41929   55.15069  1.000 42.61362  ?  730  TRP A C   1 
ATOM   5560 O  O   . TRP A 1 730 ? 12.10849  0.78083   54.88766  1.000 40.11213  ?  730  TRP A O   1 
ATOM   5561 C  CB  . TRP A 1 730 ? 8.72538   0.75457   54.72174  1.000 36.00865  ?  730  TRP A CB  1 
ATOM   5562 C  CG  . TRP A 1 730 ? 7.76685   -0.35200  54.93037  1.000 35.98553  ?  730  TRP A CG  1 
ATOM   5563 C  CD1 . TRP A 1 730 ? 7.70664   -1.19428  56.01564  1.000 34.69564  ?  730  TRP A CD1 1 
ATOM   5564 C  CD2 . TRP A 1 730 ? 6.72365   -0.76107  54.04356  1.000 31.74780  ?  730  TRP A CD2 1 
ATOM   5565 N  NE1 . TRP A 1 730 ? 6.68747   -2.09679  55.85120  1.000 35.97257  ?  730  TRP A NE1 1 
ATOM   5566 C  CE2 . TRP A 1 730 ? 6.06411   -1.85456  54.65403  1.000 32.48058  ?  730  TRP A CE2 1 
ATOM   5567 C  CE3 . TRP A 1 730 ? 6.26730   -0.30083  52.80539  1.000 31.73311  ?  730  TRP A CE3 1 
ATOM   5568 C  CZ2 . TRP A 1 730 ? 4.97460   -2.48716  54.06843  1.000 31.74335  ?  730  TRP A CZ2 1 
ATOM   5569 C  CZ3 . TRP A 1 730 ? 5.18858   -0.93558  52.21745  1.000 27.63550  ?  730  TRP A CZ3 1 
ATOM   5570 C  CH2 . TRP A 1 730 ? 4.55568   -2.02264  52.84701  1.000 30.95218  ?  730  TRP A CH2 1 
ATOM   5571 N  N   . GLN A 1 731 ? 10.98707  2.74393   55.00183  1.000 37.18903  ?  731  GLN A N   1 
ATOM   5572 C  CA  . GLN A 1 731 ? 12.03930  3.48871   54.33302  1.000 46.41093  ?  731  GLN A CA  1 
ATOM   5573 C  C   . GLN A 1 731 ? 13.39088  3.22599   54.97567  1.000 49.08386  ?  731  GLN A C   1 
ATOM   5574 O  O   . GLN A 1 731 ? 14.37848  2.96444   54.27233  1.000 43.82953  ?  731  GLN A O   1 
ATOM   5575 C  CB  . GLN A 1 731 ? 11.72577  4.98202   54.35016  1.000 48.65463  ?  731  GLN A CB  1 
ATOM   5576 C  CG  . GLN A 1 731 ? 12.54997  5.74160   53.33996  1.000 53.54762  ?  731  GLN A CG  1 
ATOM   5577 C  CD  . GLN A 1 731 ? 12.34974  5.21810   51.92644  1.000 53.22819  ?  731  GLN A CD  1 
ATOM   5578 O  OE1 . GLN A 1 731 ? 11.28095  5.39726   51.33162  1.000 57.45429  ?  731  GLN A OE1 1 
ATOM   5579 N  NE2 . GLN A 1 731 ? 13.37014  4.55869   51.38445  1.000 51.11231  ?  731  GLN A NE2 1 
ATOM   5580 N  N   . ASP A 1 732 ? 13.44191  3.22812   56.31495  1.000 47.39638  ?  732  ASP A N   1 
ATOM   5581 C  CA  . ASP A 1 732 ? 14.72935  3.05293   56.97390  1.000 50.30470  ?  732  ASP A CA  1 
ATOM   5582 C  C   . ASP A 1 732 ? 15.32610  1.69445   56.63394  1.000 43.99338  ?  732  ASP A C   1 
ATOM   5583 O  O   . ASP A 1 732 ? 16.50578  1.59774   56.26685  1.000 46.86535  ?  732  ASP A O   1 
ATOM   5584 C  CB  . ASP A 1 732 ? 14.59539  3.21536   58.48664  1.000 50.72864  ?  732  ASP A CB  1 
ATOM   5585 C  CG  . ASP A 1 732 ? 15.77835  2.61565   59.22777  1.000 65.10331  ?  732  ASP A CG  1 
ATOM   5586 O  OD1 . ASP A 1 732 ? 16.87559  3.22934   59.20075  1.000 68.18624  -1 732  ASP A OD1 1 
ATOM   5587 O  OD2 . ASP A 1 732 ? 15.62565  1.51183   59.80681  1.000 69.17519  -1 732  ASP A OD2 1 
ATOM   5588 N  N   . ILE A 1 733 ? 14.50689  0.64634   56.67669  1.000 44.39365  ?  733  ILE A N   1 
ATOM   5589 C  CA  . ILE A 1 733 ? 14.98466  -0.66656  56.25987  1.000 41.89960  ?  733  ILE A CA  1 
ATOM   5590 C  C   . ILE A 1 733 ? 15.52038  -0.59100  54.83658  1.000 46.38033  ?  733  ILE A C   1 
ATOM   5591 O  O   . ILE A 1 733 ? 16.64104  -1.04081  54.54674  1.000 45.54114  ?  733  ILE A O   1 
ATOM   5592 C  CB  . ILE A 1 733 ? 13.86475  -1.71223  56.39302  1.000 41.51546  ?  733  ILE A CB  1 
ATOM   5593 C  CG1 . ILE A 1 733 ? 13.51547  -1.92739  57.86511  1.000 49.43514  ?  733  ILE A CG1 1 
ATOM   5594 C  CG2 . ILE A 1 733 ? 14.25135  -3.00961  55.72449  1.000 38.32812  ?  733  ILE A CG2 1 
ATOM   5595 C  CD1 . ILE A 1 733 ? 12.05188  -1.67786  58.19059  1.000 47.22825  ?  733  ILE A CD1 1 
ATOM   5596 N  N   . LEU A 1 734 ? 14.75416  0.04250   53.94067  1.000 41.98050  ?  734  LEU A N   1 
ATOM   5597 C  CA  . LEU A 1 734 ? 15.19184  0.10758   52.55493  1.000 44.14869  ?  734  LEU A CA  1 
ATOM   5598 C  C   . LEU A 1 734 ? 16.49601  0.87406   52.45839  1.000 47.64649  ?  734  LEU A C   1 
ATOM   5599 O  O   . LEU A 1 734 ? 17.43830  0.42917   51.78159  1.000 43.87193  ?  734  LEU A O   1 
ATOM   5600 C  CB  . LEU A 1 734 ? 14.11232  0.73724   51.68077  1.000 41.02469  ?  734  LEU A CB  1 
ATOM   5601 C  CG  . LEU A 1 734 ? 12.86975  -0.14589  51.56884  1.000 42.73586  ?  734  LEU A CG  1 
ATOM   5602 C  CD1 . LEU A 1 734 ? 11.77264  0.51787   50.75497  1.000 34.63331  ?  734  LEU A CD1 1 
ATOM   5603 C  CD2 . LEU A 1 734 ? 13.20234  -1.53014  51.00001  1.000 36.97118  ?  734  LEU A CD2 1 
ATOM   5604 N  N   . ASP A 1 735 ? 16.60250  1.98330   53.20503  1.000 46.03021  ?  735  ASP A N   1 
ATOM   5605 C  CA  . ASP A 1 735 ? 17.79782  2.79988   53.07965  1.000 45.99709  ?  735  ASP A CA  1 
ATOM   5606 C  C   . ASP A 1 735 ? 19.01356  2.02391   53.54883  1.000 44.55079  ?  735  ASP A C   1 
ATOM   5607 O  O   . ASP A 1 735 ? 20.11574  2.22223   53.02820  1.000 41.84368  ?  735  ASP A O   1 
ATOM   5608 C  CB  . ASP A 1 735 ? 17.62734  4.11042   53.84673  1.000 47.96715  ?  735  ASP A CB  1 
ATOM   5609 C  CG  . ASP A 1 735 ? 16.68419  5.07786   53.12917  1.000 56.87454  ?  735  ASP A CG  1 
ATOM   5610 O  OD1 . ASP A 1 735 ? 15.99197  4.63065   52.19082  1.000 57.04929  ?  735  ASP A OD1 1 
ATOM   5611 O  OD2 . ASP A 1 735 ? 16.60896  6.27499   53.50272  1.000 62.91771  -1 735  ASP A OD2 1 
ATOM   5612 N  N   . LYS A 1 736 ? 18.81164  1.06983   54.45864  1.000 45.67245  ?  736  LYS A N   1 
ATOM   5613 C  CA  . LYS A 1 736 ? 19.94668  0.32850   54.98202  1.000 48.52029  ?  736  LYS A CA  1 
ATOM   5614 C  C   . LYS A 1 736 ? 20.48980  -0.65307  53.95933  1.000 45.23939  ?  736  LYS A C   1 
ATOM   5615 O  O   . LYS A 1 736 ? 21.61350  -1.13874  54.11810  1.000 47.57943  ?  736  LYS A O   1 
ATOM   5616 C  CB  . LYS A 1 736 ? 19.55269  -0.39967  56.27585  1.000 45.86750  ?  736  LYS A CB  1 
ATOM   5617 C  CG  . LYS A 1 736 ? 19.82928  0.39761   57.55040  1.000 50.46784  ?  736  LYS A CG  1 
ATOM   5618 C  CD  . LYS A 1 736 ? 18.97173  -0.04891  58.75046  1.000 55.05753  ?  736  LYS A CD  1 
ATOM   5619 C  CE  . LYS A 1 736 ? 19.42543  -1.39900  59.33483  1.000 66.79414  ?  736  LYS A CE  1 
ATOM   5620 N  NZ  . LYS A 1 736 ? 19.09328  -1.53623  60.79569  1.000 59.04374  ?  736  LYS A NZ  1 
ATOM   5621 N  N   . GLN A 1 737 ? 19.72933  -0.94950  52.90907  1.000 47.23643  ?  737  GLN A N   1 
ATOM   5622 C  CA  . GLN A 1 737 ? 20.12537  -1.96439  51.94353  1.000 47.75737  ?  737  GLN A CA  1 
ATOM   5623 C  C   . GLN A 1 737 ? 20.68971  -1.37761  50.65590  1.000 43.61583  ?  737  GLN A C   1 
ATOM   5624 O  O   . GLN A 1 737 ? 20.97068  -2.13264  49.72273  1.000 46.24072  ?  737  GLN A O   1 
ATOM   5625 C  CB  . GLN A 1 737 ? 18.94498  -2.87949  51.64251  1.000 42.20949  ?  737  GLN A CB  1 
ATOM   5626 C  CG  . GLN A 1 737 ? 18.31158  -3.40530  52.89955  1.000 48.99537  ?  737  GLN A CG  1 
ATOM   5627 C  CD  . GLN A 1 737 ? 18.91631  -4.72057  53.33734  1.000 52.40763  ?  737  GLN A CD  1 
ATOM   5628 O  OE1 . GLN A 1 737 ? 19.40389  -5.50238  52.51550  1.000 57.33956  ?  737  GLN A OE1 1 
ATOM   5629 N  NE2 . GLN A 1 737 ? 18.89058  -4.97495  54.63543  1.000 52.89018  ?  737  GLN A NE2 1 
ATOM   5630 N  N   . ARG A 1 738 ? 20.88121  -0.06233  50.59303  1.000 37.89068  ?  738  ARG A N   1 
ATOM   5631 C  CA  . ARG A 1 738 ? 21.52758  0.54750   49.43568  1.000 43.76247  ?  738  ARG A CA  1 
ATOM   5632 C  C   . ARG A 1 738 ? 22.95800  0.03967   49.29278  1.000 45.02010  ?  738  ARG A C   1 
ATOM   5633 O  O   . ARG A 1 738 ? 23.63942  -0.25208  50.28111  1.000 46.30651  ?  738  ARG A O   1 
ATOM   5634 C  CB  . ARG A 1 738 ? 21.53771  2.07682   49.55413  1.000 36.70058  ?  738  ARG A CB  1 
ATOM   5635 C  CG  . ARG A 1 738 ? 20.14907  2.70248   49.46975  1.000 41.30155  ?  738  ARG A CG  1 
ATOM   5636 C  CD  . ARG A 1 738 ? 19.66378  2.75492   48.03974  1.000 40.67552  ?  738  ARG A CD  1 
ATOM   5637 N  NE  . ARG A 1 738 ? 18.27940  3.19168   47.94952  1.000 38.72501  ?  738  ARG A NE  1 
ATOM   5638 C  CZ  . ARG A 1 738 ? 17.44798  2.87213   46.96434  1.000 43.43707  ?  738  ARG A CZ  1 
ATOM   5639 N  NH1 . ARG A 1 738 ? 17.82638  2.09149   45.95406  1.000 38.09136  ?  738  ARG A NH1 1 
ATOM   5640 N  NH2 . ARG A 1 738 ? 16.20049  3.33523   46.99939  1.000 43.07659  ?  738  ARG A NH2 1 
ATOM   5641 N  N   . PHE A 1 739 ? 23.40892  -0.05411  48.04571  1.000 44.93343  ?  739  PHE A N   1 
ATOM   5642 C  CA  . PHE A 1 739 ? 24.72627  -0.60745  47.73491  1.000 47.14199  ?  739  PHE A CA  1 
ATOM   5643 C  C   . PHE A 1 739 ? 25.79077  0.14491   48.52074  1.000 46.51493  ?  739  PHE A C   1 
ATOM   5644 O  O   . PHE A 1 739 ? 25.90476  1.37227   48.37119  1.000 41.67651  ?  739  PHE A O   1 
ATOM   5645 C  CB  . PHE A 1 739 ? 25.02796  -0.50330  46.23794  1.000 44.10390  ?  739  PHE A CB  1 
ATOM   5646 C  CG  . PHE A 1 739 ? 26.20056  -1.32702  45.79960  1.000 49.32245  ?  739  PHE A CG  1 
ATOM   5647 C  CD1 . PHE A 1 739 ? 26.04116  -2.66657  45.49093  1.000 46.70187  ?  739  PHE A CD1 1 
ATOM   5648 C  CD2 . PHE A 1 739 ? 27.46473  -0.76201  45.70261  1.000 49.60221  ?  739  PHE A CD2 1 
ATOM   5649 C  CE1 . PHE A 1 739 ? 27.13114  -3.44001  45.08456  1.000 53.05549  ?  739  PHE A CE1 1 
ATOM   5650 C  CE2 . PHE A 1 739 ? 28.54893  -1.51476  45.30354  1.000 46.82501  ?  739  PHE A CE2 1 
ATOM   5651 C  CZ  . PHE A 1 739 ? 28.38304  -2.86602  44.99880  1.000 53.73965  ?  739  PHE A CZ  1 
ATOM   5652 N  N   . PRO A 1 740 ? 26.58583  -0.53795  49.34303  1.000 46.20154  ?  740  PRO A N   1 
ATOM   5653 C  CA  . PRO A 1 740 ? 27.50351  0.16742   50.24625  1.000 53.21261  ?  740  PRO A CA  1 
ATOM   5654 C  C   . PRO A 1 740 ? 28.62526  0.86144   49.49725  1.000 54.03818  ?  740  PRO A C   1 
ATOM   5655 O  O   . PRO A 1 740 ? 29.17878  0.33048   48.53032  1.000 58.71918  ?  740  PRO A O   1 
ATOM   5656 C  CB  . PRO A 1 740 ? 28.03855  -0.94434  51.15095  1.000 52.31454  ?  740  PRO A CB  1 
ATOM   5657 C  CG  . PRO A 1 740 ? 27.74537  -2.21443  50.43137  1.000 54.47110  ?  740  PRO A CG  1 
ATOM   5658 C  CD  . PRO A 1 740 ? 26.55380  -1.98522  49.58649  1.000 52.43130  ?  740  PRO A CD  1 
ATOM   5659 N  N   . GLN A 1 741 ? 28.94915  2.05458   49.96202  1.000 56.12049  ?  741  GLN A N   1 
ATOM   5660 C  CA  . GLN A 1 741 ? 29.89451  3.01371   49.41672  1.000 57.68425  ?  741  GLN A CA  1 
ATOM   5661 C  C   . GLN A 1 741 ? 31.24770  2.89690   50.10416  1.000 64.48543  ?  741  GLN A C   1 
ATOM   5662 O  O   . GLN A 1 741 ? 31.37031  2.27824   51.16714  1.000 63.80828  ?  741  GLN A O   1 
ATOM   5663 C  CB  . GLN A 1 741 ? 29.34557  4.43385   49.58295  1.000 56.09237  ?  741  GLN A CB  1 
ATOM   5664 C  CG  . GLN A 1 741 ? 28.05867  4.66494   48.81302  1.000 58.01645  ?  741  GLN A CG  1 
ATOM   5665 C  CD  . GLN A 1 741 ? 28.19311  4.30024   47.34412  1.000 56.95698  ?  741  GLN A CD  1 
ATOM   5666 O  OE1 . GLN A 1 741 ? 29.01613  4.87104   46.62313  1.000 53.52756  ?  741  GLN A OE1 1 
ATOM   5667 N  NE2 . GLN A 1 741 ? 27.39458  3.33259   46.89789  1.000 49.66678  ?  741  GLN A NE2 1 
ATOM   5668 N  N   . PRO A 1 742 ? 32.30032  3.45911   49.51621  1.000 65.48643  ?  742  PRO A N   1 
ATOM   5669 C  CA  . PRO A 1 742 ? 33.62803  3.35239   50.13284  1.000 68.24607  ?  742  PRO A CA  1 
ATOM   5670 C  C   . PRO A 1 742 ? 33.79146  4.36101   51.25369  1.000 69.60526  ?  742  PRO A C   1 
ATOM   5671 O  O   . PRO A 1 742 ? 33.22858  5.46635   51.19742  1.000 63.36214  ?  742  PRO A O   1 
ATOM   5672 C  CB  . PRO A 1 742 ? 34.58349  3.65201   48.96774  1.000 67.76543  ?  742  PRO A CB  1 
ATOM   5673 C  CG  . PRO A 1 742 ? 33.79377  4.56665   48.08203  1.000 69.93738  ?  742  PRO A CG  1 
ATOM   5674 C  CD  . PRO A 1 742 ? 32.36416  4.08898   48.18092  1.000 62.54743  ?  742  PRO A CD  1 
ATOM   5675 N  N   . PRO A 1 743 ? 34.57580  4.02117   52.28850  1.000 72.67358  ?  743  PRO A N   1 
ATOM   5676 C  CA  . PRO A 1 743 ? 34.90670  4.91195   53.40779  1.000 72.08984  ?  743  PRO A CA  1 
ATOM   5677 C  C   . PRO A 1 743 ? 35.72491  6.12289   52.96077  1.000 73.05017  ?  743  PRO A C   1 
ATOM   5678 O  O   . PRO A 1 743 ? 35.30511  7.25620   53.20172  1.000 76.61917  ?  743  PRO A O   1 
ATOM   5679 C  CB  . PRO A 1 743 ? 35.72877  4.01386   54.33627  1.000 72.78146  ?  743  PRO A CB  1 
ATOM   5680 C  CG  . PRO A 1 743 ? 36.32092  2.98378   53.42746  1.000 73.97869  ?  743  PRO A CG  1 
ATOM   5681 C  CD  . PRO A 1 743 ? 35.24945  2.71590   52.40831  1.000 73.39592  ?  743  PRO A CD  1 
ATOM   5682 N  N   . LEU A 1 755 ? 32.59073  8.84502   41.39144  1.000 54.36543  ?  755  LEU A N   1 
ATOM   5683 C  CA  . LEU A 1 755 ? 31.24965  8.29133   41.22421  1.000 54.73810  ?  755  LEU A CA  1 
ATOM   5684 C  C   . LEU A 1 755 ? 30.95446  7.21616   42.25285  1.000 55.78954  ?  755  LEU A C   1 
ATOM   5685 O  O   . LEU A 1 755 ? 31.86162  6.46728   42.63546  1.000 56.69281  ?  755  LEU A O   1 
ATOM   5686 C  CB  . LEU A 1 755 ? 31.06385  7.69033   39.82163  1.000 56.19091  ?  755  LEU A CB  1 
ATOM   5687 C  CG  . LEU A 1 755 ? 31.11873  8.54815   38.55604  1.000 52.10672  ?  755  LEU A CG  1 
ATOM   5688 C  CD1 . LEU A 1 755 ? 31.55788  7.71277   37.37322  1.000 52.44826  ?  755  LEU A CD1 1 
ATOM   5689 C  CD2 . LEU A 1 755 ? 29.75419  9.16708   38.27263  1.000 51.80833  ?  755  LEU A CD2 1 
ATOM   5690 N  N   . PRO A 1 756 ? 29.67118  7.11923   42.67447  1.000 52.93636  ?  756  PRO A N   1 
ATOM   5691 C  CA  . PRO A 1 756 ? 29.26291  6.07044   43.62639  1.000 46.56861  ?  756  PRO A CA  1 
ATOM   5692 C  C   . PRO A 1 756 ? 29.68481  4.67566   43.18265  1.000 50.55431  ?  756  PRO A C   1 
ATOM   5693 O  O   . PRO A 1 756 ? 29.98025  4.46090   42.00065  1.000 48.52251  ?  756  PRO A O   1 
ATOM   5694 C  CB  . PRO A 1 756 ? 27.73517  6.21237   43.67576  1.000 45.69554  ?  756  PRO A CB  1 
ATOM   5695 C  CG  . PRO A 1 756 ? 27.46529  7.61453   43.26667  1.000 53.45331  ?  756  PRO A CG  1 
ATOM   5696 C  CD  . PRO A 1 756 ? 28.57623  8.04851   42.34365  1.000 53.50076  ?  756  PRO A CD  1 
ATOM   5697 N  N   . GLU A 1 757 ? 29.67057  3.71564   44.11188  1.000 46.36343  ?  757  GLU A N   1 
ATOM   5698 C  CA  . GLU A 1 757 ? 30.57311  2.57737   44.00099  1.000 49.60180  ?  757  GLU A CA  1 
ATOM   5699 C  C   . GLU A 1 757 ? 30.34760  1.72030   42.76475  1.000 56.31914  ?  757  GLU A C   1 
ATOM   5700 O  O   . GLU A 1 757 ? 31.26072  1.67725   41.90790  1.000 56.91922  ?  757  GLU A O   1 
ATOM   5701 C  CB  . GLU A 1 757 ? 30.51743  1.67311   45.22749  1.000 57.05272  ?  757  GLU A CB  1 
ATOM   5702 C  CG  . GLU A 1 757 ? 31.55500  0.53613   45.14904  1.000 60.16191  ?  757  GLU A CG  1 
ATOM   5703 C  CD  . GLU A 1 757 ? 32.80486  0.92140   44.34360  1.000 66.20460  ?  757  GLU A CD  1 
ATOM   5704 O  OE1 . GLU A 1 757 ? 33.60474  1.73184   44.85982  1.000 73.04478  ?  757  GLU A OE1 1 
ATOM   5705 O  OE2 . GLU A 1 757 ? 32.97487  0.44217   43.18980  1.000 56.82870  -1 757  GLU A OE2 1 
ATOM   5706 N  N   . PRO A 1 758 ? 29.19046  1.02383   42.61706  1.000 52.01241  ?  758  PRO A N   1 
ATOM   5707 C  CA  . PRO A 1 758 ? 29.13228  -0.00202  41.55454  1.000 48.56847  ?  758  PRO A CA  1 
ATOM   5708 C  C   . PRO A 1 758 ? 29.55346  0.61152   40.24600  1.000 44.76552  ?  758  PRO A C   1 
ATOM   5709 O  O   . PRO A 1 758 ? 30.37420  0.03870   39.52103  1.000 45.48407  ?  758  PRO A O   1 
ATOM   5710 C  CB  . PRO A 1 758 ? 27.67029  -0.46977  41.55508  1.000 42.67914  ?  758  PRO A CB  1 
ATOM   5711 C  CG  . PRO A 1 758 ? 26.90549  0.70685   42.11820  1.000 46.10632  ?  758  PRO A CG  1 
ATOM   5712 C  CD  . PRO A 1 758 ? 27.84487  1.39864   43.10580  1.000 44.39999  ?  758  PRO A CD  1 
ATOM   5713 N  N   . PHE A 1 759 ? 29.13042  1.85449   40.03331  1.000 42.43830  ?  759  PHE A N   1 
ATOM   5714 C  CA  . PHE A 1 759 ? 29.50147  2.59582   38.84038  1.000 45.22818  ?  759  PHE A CA  1 
ATOM   5715 C  C   . PHE A 1 759 ? 31.00663  2.82064   38.74849  1.000 45.98565  ?  759  PHE A C   1 
ATOM   5716 O  O   . PHE A 1 759 ? 31.58249  2.69602   37.66247  1.000 44.39728  ?  759  PHE A O   1 
ATOM   5717 C  CB  . PHE A 1 759 ? 28.74010  3.91452   38.82375  1.000 43.66614  ?  759  PHE A CB  1 
ATOM   5718 C  CG  . PHE A 1 759 ? 27.25961  3.73672   38.98675  1.000 46.59378  ?  759  PHE A CG  1 
ATOM   5719 C  CD1 . PHE A 1 759 ? 26.44862  3.50980   37.87802  1.000 44.88488  ?  759  PHE A CD1 1 
ATOM   5720 C  CD2 . PHE A 1 759 ? 26.68402  3.74037   40.24709  1.000 45.79935  ?  759  PHE A CD2 1 
ATOM   5721 C  CE1 . PHE A 1 759 ? 25.08781  3.32145   38.02558  1.000 41.74925  ?  759  PHE A CE1 1 
ATOM   5722 C  CE2 . PHE A 1 759 ? 25.32709  3.54727   40.40171  1.000 41.95808  ?  759  PHE A CE2 1 
ATOM   5723 C  CZ  . PHE A 1 759 ? 24.52829  3.33954   39.28996  1.000 45.29534  ?  759  PHE A CZ  1 
ATOM   5724 N  N   . GLU A 1 760 ? 31.66198  3.17799   39.86155  1.000 47.53905  ?  760  GLU A N   1 
ATOM   5725 C  CA  . GLU A 1 760 ? 33.09601  3.47441   39.80443  1.000 46.46477  ?  760  GLU A CA  1 
ATOM   5726 C  C   . GLU A 1 760 ? 33.89646  2.23721   39.40476  1.000 45.60954  ?  760  GLU A C   1 
ATOM   5727 O  O   . GLU A 1 760 ? 34.73262  2.28625   38.48716  1.000 43.90125  ?  760  GLU A O   1 
ATOM   5728 C  CB  . GLU A 1 760 ? 33.58071  4.01956   41.14762  1.000 51.56150  ?  760  GLU A CB  1 
ATOM   5729 C  CG  . GLU A 1 760 ? 35.07063  4.33529   41.18857  1.000 46.99716  ?  760  GLU A CG  1 
ATOM   5730 C  CD  . GLU A 1 760 ? 35.42769  5.50890   40.29256  1.000 49.56186  ?  760  GLU A CD  1 
ATOM   5731 O  OE1 . GLU A 1 760 ? 34.61350  6.45134   40.19192  1.000 57.04134  ?  760  GLU A OE1 1 
ATOM   5732 O  OE2 . GLU A 1 760 ? 36.51923  5.49502   39.69420  1.000 48.30562  -1 760  GLU A OE2 1 
ATOM   5733 N  N   . SER A 1 761 ? 33.63189  1.10974   40.06812  1.000 42.22392  ?  761  SER A N   1 
ATOM   5734 C  CA  . SER A 1 761 ? 34.25324  -0.14646  39.64754  1.000 45.43031  ?  761  SER A CA  1 
ATOM   5735 C  C   . SER A 1 761 ? 33.93356  -0.46389  38.18907  1.000 43.02696  ?  761  SER A C   1 
ATOM   5736 O  O   . SER A 1 761 ? 34.81332  -0.87445  37.42288  1.000 44.28417  ?  761  SER A O   1 
ATOM   5737 C  CB  . SER A 1 761 ? 33.78183  -1.29095  40.54047  1.000 49.52103  ?  761  SER A CB  1 
ATOM   5738 O  OG  . SER A 1 761 ? 34.80140  -1.71809  41.41513  1.000 58.99592  ?  761  SER A OG  1 
ATOM   5739 N  N   . TRP A 1 762 ? 32.67961  -0.27097  37.78541  1.000 44.46944  ?  762  TRP A N   1 
ATOM   5740 C  CA  . TRP A 1 762 ? 32.26955  -0.63872  36.43726  1.000 41.94903  ?  762  TRP A CA  1 
ATOM   5741 C  C   . TRP A 1 762 ? 33.01045  0.18088   35.38744  1.000 43.06192  ?  762  TRP A C   1 
ATOM   5742 O  O   . TRP A 1 762 ? 33.52367  -0.36685  34.40127  1.000 38.58841  ?  762  TRP A O   1 
ATOM   5743 C  CB  . TRP A 1 762 ? 30.75768  -0.46350  36.32370  1.000 40.12342  ?  762  TRP A CB  1 
ATOM   5744 C  CG  . TRP A 1 762 ? 29.97567  -1.64843  36.88047  1.000 38.84796  ?  762  TRP A CG  1 
ATOM   5745 C  CD1 . TRP A 1 762 ? 30.46115  -2.87940  37.16890  1.000 37.45852  ?  762  TRP A CD1 1 
ATOM   5746 C  CD2 . TRP A 1 762 ? 28.57416  -1.68605  37.19791  1.000 37.34487  ?  762  TRP A CD2 1 
ATOM   5747 N  NE1 . TRP A 1 762 ? 29.44839  -3.69978  37.63596  1.000 41.69978  ?  762  TRP A NE1 1 
ATOM   5748 C  CE2 . TRP A 1 762 ? 28.28053  -2.98757  37.65789  1.000 37.15036  ?  762  TRP A CE2 1 
ATOM   5749 C  CE3 . TRP A 1 762 ? 27.54117  -0.75658  37.11651  1.000 36.38853  ?  762  TRP A CE3 1 
ATOM   5750 C  CZ2 . TRP A 1 762 ? 27.00496  -3.37005  38.04503  1.000 31.17593  ?  762  TRP A CZ2 1 
ATOM   5751 C  CZ3 . TRP A 1 762 ? 26.26801  -1.14585  37.50957  1.000 36.27722  ?  762  TRP A CZ3 1 
ATOM   5752 C  CH2 . TRP A 1 762 ? 26.01450  -2.43042  37.96191  1.000 31.22791  ?  762  TRP A CH2 1 
ATOM   5753 N  N   . PHE A 1 763 ? 33.09725  1.49691   35.59851  1.000 44.30488  ?  763  PHE A N   1 
ATOM   5754 C  CA  . PHE A 1 763 ? 33.76453  2.35421   34.63378  1.000 42.53144  ?  763  PHE A CA  1 
ATOM   5755 C  C   . PHE A 1 763 ? 35.26139  2.06431   34.59555  1.000 46.29036  ?  763  PHE A C   1 
ATOM   5756 O  O   . PHE A 1 763 ? 35.86335  2.07688   33.51573  1.000 41.09360  ?  763  PHE A O   1 
ATOM   5757 C  CB  . PHE A 1 763 ? 33.46253  3.83235   34.92817  1.000 44.05613  ?  763  PHE A CB  1 
ATOM   5758 C  CG  . PHE A 1 763 ? 32.16158  4.31840   34.29638  1.000 46.76435  ?  763  PHE A CG  1 
ATOM   5759 C  CD1 . PHE A 1 763 ? 32.01075  4.35295   32.91627  1.000 48.64753  ?  763  PHE A CD1 1 
ATOM   5760 C  CD2 . PHE A 1 763 ? 31.08685  4.70712   35.07965  1.000 43.45733  ?  763  PHE A CD2 1 
ATOM   5761 C  CE1 . PHE A 1 763 ? 30.81027  4.77231   32.32345  1.000 46.20192  ?  763  PHE A CE1 1 
ATOM   5762 C  CE2 . PHE A 1 763 ? 29.88640  5.12195   34.49569  1.000 45.83420  ?  763  PHE A CE2 1 
ATOM   5763 C  CZ  . PHE A 1 763 ? 29.75410  5.15347   33.11849  1.000 44.52901  ?  763  PHE A CZ  1 
ATOM   5764 N  N   . GLY A 1 764 ? 35.87102  1.75465   35.75129  1.000 43.64902  ?  764  GLY A N   1 
ATOM   5765 C  CA  . GLY A 1 764 ? 37.26657  1.34729   35.74164  1.000 39.96251  ?  764  GLY A CA  1 
ATOM   5766 C  C   . GLY A 1 764 ? 37.48658  0.06319   34.96229  1.000 45.95396  ?  764  GLY A C   1 
ATOM   5767 O  O   . GLY A 1 764 ? 38.49643  -0.08898  34.26573  1.000 46.21147  ?  764  GLY A O   1 
ATOM   5768 N  N   . LEU A 1 765 ? 36.53614  -0.87490  35.06303  1.000 42.67206  ?  765  LEU A N   1 
ATOM   5769 C  CA  . LEU A 1 765 ? 36.59769  -2.09841  34.26173  1.000 44.93229  ?  765  LEU A CA  1 
ATOM   5770 C  C   . LEU A 1 765 ? 36.50821  -1.79791  32.76636  1.000 47.44093  ?  765  LEU A C   1 
ATOM   5771 O  O   . LEU A 1 765 ? 37.17451  -2.44932  31.95243  1.000 48.10416  ?  765  LEU A O   1 
ATOM   5772 C  CB  . LEU A 1 765 ? 35.47149  -3.05116  34.66780  1.000 44.20305  ?  765  LEU A CB  1 
ATOM   5773 C  CG  . LEU A 1 765 ? 35.69482  -4.05522  35.79694  1.000 45.92689  ?  765  LEU A CG  1 
ATOM   5774 C  CD1 . LEU A 1 765 ? 34.42090  -4.82412  36.13011  1.000 41.29973  ?  765  LEU A CD1 1 
ATOM   5775 C  CD2 . LEU A 1 765 ? 36.80496  -5.01741  35.42852  1.000 47.97283  ?  765  LEU A CD2 1 
ATOM   5776 N  N   . LEU A 1 766 ? 35.65488  -0.84595  32.38169  1.000 45.51055  ?  766  LEU A N   1 
ATOM   5777 C  CA  . LEU A 1 766 ? 35.58037  -0.46051  30.97542  1.000 44.88863  ?  766  LEU A CA  1 
ATOM   5778 C  C   . LEU A 1 766 ? 36.88344  0.19130   30.51693  1.000 49.40842  ?  766  LEU A C   1 
ATOM   5779 O  O   . LEU A 1 766 ? 37.33391  -0.01149  29.38040  1.000 43.08248  ?  766  LEU A O   1 
ATOM   5780 C  CB  . LEU A 1 766 ? 34.39769  0.48640   30.75230  1.000 46.03688  ?  766  LEU A CB  1 
ATOM   5781 C  CG  . LEU A 1 766 ? 33.00346  -0.13708  30.62575  1.000 41.81140  ?  766  LEU A CG  1 
ATOM   5782 C  CD1 . LEU A 1 766 ? 32.01045  0.88183   30.14168  1.000 47.61966  ?  766  LEU A CD1 1 
ATOM   5783 C  CD2 . LEU A 1 766 ? 33.02869  -1.34992  29.69645  1.000 46.24028  ?  766  LEU A CD2 1 
ATOM   5784 N  N   . GLU A 1 767 ? 37.49029  0.98765   31.39337  1.000 48.13774  ?  767  GLU A N   1 
ATOM   5785 C  CA  . GLU A 1 767 ? 38.71687  1.69964   31.05040  1.000 50.90583  ?  767  GLU A CA  1 
ATOM   5786 C  C   . GLU A 1 767 ? 39.89001  0.74140   30.87904  1.000 54.78892  ?  767  GLU A C   1 
ATOM   5787 O  O   . GLU A 1 767 ? 40.73723  0.94179   29.99892  1.000 56.24291  ?  767  GLU A O   1 
ATOM   5788 C  CB  . GLU A 1 767 ? 39.02109  2.74622   32.11878  1.000 41.61351  ?  767  GLU A CB  1 
ATOM   5789 C  CG  . GLU A 1 767 ? 38.23790  4.02543   31.93472  1.000 44.72787  ?  767  GLU A CG  1 
ATOM   5790 C  CD  . GLU A 1 767 ? 38.03099  4.77136   33.23950  1.000 52.25745  ?  767  GLU A CD  1 
ATOM   5791 O  OE1 . GLU A 1 767 ? 38.49713  4.26806   34.28732  1.000 53.12374  ?  767  GLU A OE1 1 
ATOM   5792 O  OE2 . GLU A 1 767 ? 37.41712  5.86237   33.21153  1.000 51.55550  -1 767  GLU A OE2 1 
ATOM   5793 N  N   . SER A 1 768 ? 39.95782  -0.31013  31.69917  1.000 49.29406  ?  768  SER A N   1 
ATOM   5794 C  CA  . SER A 1 768 ? 41.07081  -1.24385  31.57111  1.000 50.29102  ?  768  SER A CA  1 
ATOM   5795 C  C   . SER A 1 768 ? 40.95965  -2.08961  30.29476  1.000 49.83413  ?  768  SER A C   1 
ATOM   5796 O  O   . SER A 1 768 ? 41.91355  -2.17177  29.51301  1.000 54.58285  ?  768  SER A O   1 
ATOM   5797 C  CB  . SER A 1 768 ? 41.16599  -2.11389  32.83449  1.000 46.73233  ?  768  SER A CB  1 
ATOM   5798 O  OG  . SER A 1 768 ? 40.70879  -3.44062  32.62937  1.000 55.51590  ?  768  SER A OG  1 
ATOM   5799 N  N   . ASP A 1 769 ? 39.80323  -2.71570  30.05377  1.000 47.48420  ?  769  ASP A N   1 
ATOM   5800 C  CA  . ASP A 1 769 ? 39.61867  -3.57285  28.87843  1.000 48.60377  ?  769  ASP A CA  1 
ATOM   5801 C  C   . ASP A 1 769 ? 38.13952  -3.72415  28.53582  1.000 46.57904  ?  769  ASP A C   1 
ATOM   5802 O  O   . ASP A 1 769 ? 37.45653  -4.61838  29.06022  1.000 43.60484  ?  769  ASP A O   1 
ATOM   5803 C  CB  . ASP A 1 769 ? 40.24936  -4.95368  29.09352  1.000 46.60099  ?  769  ASP A CB  1 
ATOM   5804 C  CG  . ASP A 1 769 ? 40.42486  -5.73562  27.79324  1.000 52.75246  ?  769  ASP A CG  1 
ATOM   5805 O  OD1 . ASP A 1 769 ? 39.50560  -5.72766  26.93413  1.000 50.43114  ?  769  ASP A OD1 1 
ATOM   5806 O  OD2 . ASP A 1 769 ? 41.48223  -6.38464  27.63414  1.000 58.22035  -1 769  ASP A OD2 1 
ATOM   5807 N  N   . PRO A 1 770 ? 37.62302  -2.88718  27.63375  1.000 45.96886  ?  770  PRO A N   1 
ATOM   5808 C  CA  . PRO A 1 770 ? 36.17306  -2.85851  27.38845  1.000 45.39784  ?  770  PRO A CA  1 
ATOM   5809 C  C   . PRO A 1 770 ? 35.62875  -4.07354  26.65629  1.000 45.70417  ?  770  PRO A C   1 
ATOM   5810 O  O   . PRO A 1 770 ? 34.40588  -4.24660  26.63107  1.000 41.36956  ?  770  PRO A O   1 
ATOM   5811 C  CB  . PRO A 1 770 ? 35.98936  -1.58775  26.55264  1.000 43.34205  ?  770  PRO A CB  1 
ATOM   5812 C  CG  . PRO A 1 770 ? 37.31398  -1.37643  25.89347  1.000 42.99041  ?  770  PRO A CG  1 
ATOM   5813 C  CD  . PRO A 1 770 ? 38.34242  -1.85518  26.86531  1.000 47.55040  ?  770  PRO A CD  1 
ATOM   5814 N  N   . LEU A 1 771 ? 36.47167  -4.90168  26.04102  1.000 49.10359  ?  771  LEU A N   1 
ATOM   5815 C  CA  . LEU A 1 771 ? 35.97027  -6.09512  25.36507  1.000 45.29719  ?  771  LEU A CA  1 
ATOM   5816 C  C   . LEU A 1 771 ? 35.95194  -7.29070  26.30617  1.000 46.59516  ?  771  LEU A C   1 
ATOM   5817 O  O   . LEU A 1 771 ? 34.98279  -8.05851  26.32524  1.000 47.35852  ?  771  LEU A O   1 
ATOM   5818 C  CB  . LEU A 1 771 ? 36.82055  -6.39200  24.12138  1.000 44.23825  ?  771  LEU A CB  1 
ATOM   5819 C  CG  . LEU A 1 771 ? 36.62142  -7.71947  23.37566  1.000 41.19872  ?  771  LEU A CG  1 
ATOM   5820 C  CD1 . LEU A 1 771 ? 35.21554  -7.86111  22.82479  1.000 44.82915  ?  771  LEU A CD1 1 
ATOM   5821 C  CD2 . LEU A 1 771 ? 37.63813  -7.86329  22.23498  1.000 40.66800  ?  771  LEU A CD2 1 
ATOM   5822 N  N   . LYS A 1 772 ? 37.01394  -7.44370  27.09725  1.000 47.49741  ?  772  LYS A N   1 
ATOM   5823 C  CA  . LYS A 1 772 ? 37.02341  -8.44099  28.15913  1.000 53.09069  ?  772  LYS A CA  1 
ATOM   5824 C  C   . LYS A 1 772 ? 35.87125  -8.21132  29.13249  1.000 52.83092  ?  772  LYS A C   1 
ATOM   5825 O  O   . LYS A 1 772 ? 35.16957  -9.15292  29.52455  1.000 53.22361  ?  772  LYS A O   1 
ATOM   5826 C  CB  . LYS A 1 772 ? 38.36660  -8.38718  28.89333  1.000 54.48283  ?  772  LYS A CB  1 
ATOM   5827 C  CG  . LYS A 1 772 ? 38.52357  -9.41410  30.01022  1.000 59.52543  ?  772  LYS A CG  1 
ATOM   5828 C  CD  . LYS A 1 772 ? 39.99090  -9.79257  30.22306  1.000 67.84272  ?  772  LYS A CD  1 
ATOM   5829 C  CE  . LYS A 1 772 ? 40.40082  -9.64903  31.69278  1.000 69.69381  ?  772  LYS A CE  1 
ATOM   5830 N  NZ  . LYS A 1 772 ? 41.82946  -9.23854  31.87121  1.000 62.77181  ?  772  LYS A NZ  1 
ATOM   5831 N  N   . HIS A 1 773 ? 35.65654  -6.96532  29.52528  1.000 50.76710  ?  773  HIS A N   1 
ATOM   5832 C  CA  . HIS A 1 773 ? 34.58466  -6.61192  30.44315  1.000 51.07072  ?  773  HIS A CA  1 
ATOM   5833 C  C   . HIS A 1 773 ? 33.42170  -5.94352  29.72067  1.000 44.37443  ?  773  HIS A C   1 
ATOM   5834 O  O   . HIS A 1 773 ? 32.79198  -5.03672  30.25665  1.000 42.28348  ?  773  HIS A O   1 
ATOM   5835 C  CB  . HIS A 1 773 ? 35.11431  -5.71654  31.55620  1.000 50.58574  ?  773  HIS A CB  1 
ATOM   5836 C  CG  . HIS A 1 773 ? 36.41493  -6.18796  32.11999  1.000 55.29882  ?  773  HIS A CG  1 
ATOM   5837 N  ND1 . HIS A 1 773 ? 37.56635  -5.42722  32.07955  1.000 53.93666  ?  773  HIS A ND1 1 
ATOM   5838 C  CD2 . HIS A 1 773 ? 36.75322  -7.35851  32.71231  1.000 54.90671  ?  773  HIS A CD2 1 
ATOM   5839 C  CE1 . HIS A 1 773 ? 38.55578  -6.10540  32.63465  1.000 53.00436  ?  773  HIS A CE1 1 
ATOM   5840 N  NE2 . HIS A 1 773 ? 38.08949  -7.27916  33.02773  1.000 58.98074  ?  773  HIS A NE2 1 
ATOM   5841 N  N   . LYS A 1 774 ? 33.11803  -6.39041  28.49629  1.000 45.05884  ?  774  LYS A N   1 
ATOM   5842 C  CA  . LYS A 1 774 ? 31.99787  -5.80736  27.76512  1.000 42.53990  ?  774  LYS A CA  1 
ATOM   5843 C  C   . LYS A 1 774 ? 30.66860  -6.06000  28.46044  1.000 40.34928  ?  774  LYS A C   1 
ATOM   5844 O  O   . LYS A 1 774 ? 29.70278  -5.31955  28.22658  1.000 35.37839  ?  774  LYS A O   1 
ATOM   5845 C  CB  . LYS A 1 774 ? 31.97371  -6.33790  26.33486  1.000 42.87584  ?  774  LYS A CB  1 
ATOM   5846 C  CG  . LYS A 1 774 ? 31.65483  -7.81584  26.17812  1.000 44.17158  ?  774  LYS A CG  1 
ATOM   5847 C  CD  . LYS A 1 774 ? 31.37854  -8.09419  24.69355  1.000 49.48575  ?  774  LYS A CD  1 
ATOM   5848 C  CE  . LYS A 1 774 ? 30.80459  -9.49311  24.44364  1.000 48.91871  ?  774  LYS A CE  1 
ATOM   5849 N  NZ  . LYS A 1 774 ? 31.89511  -10.51581 24.50812  1.000 51.24649  ?  774  LYS A NZ  1 
ATOM   5850 N  N   . TRP A 1 775 ? 30.61532  -7.04909  29.35840  1.000 42.24169  ?  775  TRP A N   1 
ATOM   5851 C  CA  . TRP A 1 775 ? 29.38776  -7.30343  30.10529  1.000 44.31035  ?  775  TRP A CA  1 
ATOM   5852 C  C   . TRP A 1 775 ? 28.94654  -6.07133  30.89517  1.000 41.19802  ?  775  TRP A C   1 
ATOM   5853 O  O   . TRP A 1 775 ? 27.74598  -5.89109  31.14187  1.000 41.36101  ?  775  TRP A O   1 
ATOM   5854 C  CB  . TRP A 1 775 ? 29.56939  -8.52218  31.02495  1.000 37.94244  ?  775  TRP A CB  1 
ATOM   5855 C  CG  . TRP A 1 775 ? 30.68690  -8.40455  32.03057  1.000 43.68864  ?  775  TRP A CG  1 
ATOM   5856 C  CD1 . TRP A 1 775 ? 31.95230  -8.92742  31.92645  1.000 40.40489  ?  775  TRP A CD1 1 
ATOM   5857 C  CD2 . TRP A 1 775 ? 30.64077  -7.73156  33.30078  1.000 46.44002  ?  775  TRP A CD2 1 
ATOM   5858 N  NE1 . TRP A 1 775 ? 32.68422  -8.62725  33.04839  1.000 39.30681  ?  775  TRP A NE1 1 
ATOM   5859 C  CE2 . TRP A 1 775 ? 31.91272  -7.89090  33.90586  1.000 41.24595  ?  775  TRP A CE2 1 
ATOM   5860 C  CE3 . TRP A 1 775 ? 29.65131  -7.01389  33.98487  1.000 44.25780  ?  775  TRP A CE3 1 
ATOM   5861 C  CZ2 . TRP A 1 775 ? 32.21817  -7.36517  35.15760  1.000 38.96562  ?  775  TRP A CZ2 1 
ATOM   5862 C  CZ3 . TRP A 1 775 ? 29.96448  -6.47614  35.23478  1.000 44.51002  ?  775  TRP A CZ3 1 
ATOM   5863 C  CH2 . TRP A 1 775 ? 31.23968  -6.66192  35.80644  1.000 43.40877  ?  775  TRP A CH2 1 
ATOM   5864 N  N   . VAL A 1 776 ? 29.88971  -5.19071  31.25237  1.000 41.40850  ?  776  VAL A N   1 
ATOM   5865 C  CA  . VAL A 1 776 ? 29.53079  -3.97388  31.97391  1.000 35.43047  ?  776  VAL A CA  1 
ATOM   5866 C  C   . VAL A 1 776 ? 28.55380  -3.14731  31.15519  1.000 40.46385  ?  776  VAL A C   1 
ATOM   5867 O  O   . VAL A 1 776 ? 27.60952  -2.56075  31.69782  1.000 41.42956  ?  776  VAL A O   1 
ATOM   5868 C  CB  . VAL A 1 776 ? 30.78893  -3.16014  32.33055  1.000 41.14111  ?  776  VAL A CB  1 
ATOM   5869 C  CG1 . VAL A 1 776 ? 30.39720  -1.74207  32.78043  1.000 33.43824  ?  776  VAL A CG1 1 
ATOM   5870 C  CG2 . VAL A 1 776 ? 31.61164  -3.86425  33.40913  1.000 35.79116  ?  776  VAL A CG2 1 
ATOM   5871 N  N   . TYR A 1 777 ? 28.76417  -3.09096  29.83319  1.000 39.65428  ?  777  TYR A N   1 
ATOM   5872 C  CA  . TYR A 1 777 ? 27.85061  -2.36035  28.96195  1.000 39.40207  ?  777  TYR A CA  1 
ATOM   5873 C  C   . TYR A 1 777 ? 26.41441  -2.79835  29.21359  1.000 36.99641  ?  777  TYR A C   1 
ATOM   5874 O  O   . TYR A 1 777 ? 25.52722  -1.96424  29.44001  1.000 39.26433  ?  777  TYR A O   1 
ATOM   5875 C  CB  . TYR A 1 777 ? 28.23500  -2.57019  27.49048  1.000 34.48125  ?  777  TYR A CB  1 
ATOM   5876 C  CG  . TYR A 1 777 ? 29.50387  -1.86508  27.04119  1.000 37.63450  ?  777  TYR A CG  1 
ATOM   5877 C  CD1 . TYR A 1 777 ? 29.61800  -0.48080  27.10808  1.000 37.73670  ?  777  TYR A CD1 1 
ATOM   5878 C  CD2 . TYR A 1 777 ? 30.57940  -2.57786  26.54297  1.000 35.57051  ?  777  TYR A CD2 1 
ATOM   5879 C  CE1 . TYR A 1 777 ? 30.76597  0.17211   26.69202  1.000 35.74571  ?  777  TYR A CE1 1 
ATOM   5880 C  CE2 . TYR A 1 777 ? 31.73717  -1.93169  26.12290  1.000 39.65971  ?  777  TYR A CE2 1 
ATOM   5881 C  CZ  . TYR A 1 777 ? 31.82717  -0.55428  26.19844  1.000 38.26302  ?  777  TYR A CZ  1 
ATOM   5882 O  OH  . TYR A 1 777 ? 32.98384  0.09488   25.77626  1.000 37.62161  ?  777  TYR A OH  1 
ATOM   5883 N  N   . ARG A 1 778 ? 26.18797  -4.11826  29.27931  1.000 40.53869  ?  778  ARG A N   1 
ATOM   5884 C  CA  . ARG A 1 778 ? 24.83006  -4.60675  29.50875  1.000 42.72964  ?  778  ARG A CA  1 
ATOM   5885 C  C   . ARG A 1 778 ? 24.29712  -4.14995  30.86933  1.000 40.20978  ?  778  ARG A C   1 
ATOM   5886 O  O   . ARG A 1 778 ? 23.13440  -3.72841  30.97986  1.000 45.88025  ?  778  ARG A O   1 
ATOM   5887 C  CB  . ARG A 1 778 ? 24.79762  -6.12931  29.36799  1.000 40.64679  ?  778  ARG A CB  1 
ATOM   5888 C  CG  . ARG A 1 778 ? 24.83673  -6.54614  27.91405  1.000 43.50325  ?  778  ARG A CG  1 
ATOM   5889 C  CD  . ARG A 1 778 ? 24.60355  -8.03509  27.70489  1.000 47.74676  ?  778  ARG A CD  1 
ATOM   5890 N  NE  . ARG A 1 778 ? 24.74967  -8.40176  26.29921  1.000 48.90612  ?  778  ARG A NE  1 
ATOM   5891 C  CZ  . ARG A 1 778 ? 25.26756  -9.54613  25.86551  1.000 44.92687  ?  778  ARG A CZ  1 
ATOM   5892 N  NH1 . ARG A 1 778 ? 25.71938  -10.46340 26.70539  1.000 45.73825  ?  778  ARG A NH1 1 
ATOM   5893 N  NH2 . ARG A 1 778 ? 25.33060  -9.77577  24.55550  1.000 36.06074  ?  778  ARG A NH2 1 
ATOM   5894 N  N   . LYS A 1 779 ? 25.14673  -4.17253  31.90446  1.000 37.10243  ?  779  LYS A N   1 
ATOM   5895 C  CA  . LYS A 1 779 ? 24.71999  -3.68774  33.21081  1.000 36.27581  ?  779  LYS A CA  1 
ATOM   5896 C  C   . LYS A 1 779 ? 24.30960  -2.22643  33.13738  1.000 42.91234  ?  779  LYS A C   1 
ATOM   5897 O  O   . LYS A 1 779 ? 23.26877  -1.83728  33.68969  1.000 42.66876  ?  779  LYS A O   1 
ATOM   5898 C  CB  . LYS A 1 779 ? 25.83721  -3.85516  34.23592  1.000 40.38499  ?  779  LYS A CB  1 
ATOM   5899 C  CG  . LYS A 1 779 ? 26.21253  -5.29295  34.51928  1.000 44.04837  ?  779  LYS A CG  1 
ATOM   5900 C  CD  . LYS A 1 779 ? 25.49973  -5.78901  35.75478  1.000 43.97249  ?  779  LYS A CD  1 
ATOM   5901 C  CE  . LYS A 1 779 ? 25.94352  -7.19598  36.10817  1.000 43.75313  ?  779  LYS A CE  1 
ATOM   5902 N  NZ  . LYS A 1 779 ? 24.84753  -7.86524  36.84098  1.000 51.91134  ?  779  LYS A NZ  1 
ATOM   5903 N  N   . LEU A 1 780 ? 25.08876  -1.40259  32.42173  1.000 37.76381  ?  780  LEU A N   1 
ATOM   5904 C  CA  . LEU A 1 780 ? 24.78055  0.02102   32.42488  1.000 37.59818  ?  780  LEU A CA  1 
ATOM   5905 C  C   . LEU A 1 780 ? 23.44078  0.27807   31.76695  1.000 40.61306  ?  780  LEU A C   1 
ATOM   5906 O  O   . LEU A 1 780 ? 22.84783  1.34791   31.96669  1.000 39.47941  ?  780  LEU A O   1 
ATOM   5907 C  CB  . LEU A 1 780 ? 25.89755  0.81783   31.74052  1.000 36.01135  ?  780  LEU A CB  1 
ATOM   5908 C  CG  . LEU A 1 780 ? 27.18276  0.79040   32.57563  1.000 39.66011  ?  780  LEU A CG  1 
ATOM   5909 C  CD1 . LEU A 1 780 ? 28.40039  1.25984   31.78515  1.000 41.48610  ?  780  LEU A CD1 1 
ATOM   5910 C  CD2 . LEU A 1 780 ? 27.02571  1.60614   33.87061  1.000 38.91470  ?  780  LEU A CD2 1 
ATOM   5911 N  N   . GLN A 1 781 ? 22.92622  -0.71824  31.03502  1.000 43.06448  ?  781  GLN A N   1 
ATOM   5912 C  CA  . GLN A 1 781 ? 21.64869  -0.55981  30.36238  1.000 40.27986  ?  781  GLN A CA  1 
ATOM   5913 C  C   . GLN A 1 781 ? 20.51990  -0.33824  31.35170  1.000 34.57454  ?  781  GLN A C   1 
ATOM   5914 O  O   . GLN A 1 781 ? 19.50065  0.25390   30.99087  1.000 32.68379  ?  781  GLN A O   1 
ATOM   5915 C  CB  . GLN A 1 781 ? 21.37484  -1.78611  29.49682  1.000 40.67356  ?  781  GLN A CB  1 
ATOM   5916 C  CG  . GLN A 1 781 ? 22.14823  -1.76153  28.21230  1.000 45.73490  ?  781  GLN A CG  1 
ATOM   5917 C  CD  . GLN A 1 781 ? 21.26251  -2.02498  27.03493  1.000 54.29278  ?  781  GLN A CD  1 
ATOM   5918 O  OE1 . GLN A 1 781 ? 20.91836  -3.17732  26.76234  1.000 58.49105  ?  781  GLN A OE1 1 
ATOM   5919 N  NE2 . GLN A 1 781 ? 20.84517  -0.96026  26.34488  1.000 54.75581  ?  781  GLN A NE2 1 
ATOM   5920 N  N   . ARG A 1 782 ? 20.66875  -0.82981  32.58834  1.000 34.60855  ?  782  ARG A N   1 
ATOM   5921 C  CA  . ARG A 1 782 ? 19.62885  -0.64693  33.59626  1.000 34.02343  ?  782  ARG A CA  1 
ATOM   5922 C  C   . ARG A 1 782 ? 19.69966  0.71701   34.26308  1.000 35.02239  ?  782  ARG A C   1 
ATOM   5923 O  O   . ARG A 1 782 ? 18.78627  1.05207   35.03381  1.000 33.46132  ?  782  ARG A O   1 
ATOM   5924 C  CB  . ARG A 1 782 ? 19.71934  -1.70708  34.69559  1.000 33.95089  ?  782  ARG A CB  1 
ATOM   5925 C  CG  . ARG A 1 782 ? 19.59686  -3.15677  34.28027  1.000 39.10086  ?  782  ARG A CG  1 
ATOM   5926 C  CD  . ARG A 1 782 ? 19.51614  -4.03434  35.55906  1.000 32.47336  ?  782  ARG A CD  1 
ATOM   5927 N  NE  . ARG A 1 782 ? 18.26590  -3.81940  36.26901  1.000 29.09956  ?  782  ARG A NE  1 
ATOM   5928 C  CZ  . ARG A 1 782 ? 18.11883  -3.84354  37.58683  1.000 32.91608  ?  782  ARG A CZ  1 
ATOM   5929 N  NH1 . ARG A 1 782 ? 19.13302  -4.11578  38.39366  1.000 33.65289  ?  782  ARG A NH1 1 
ATOM   5930 N  NH2 . ARG A 1 782 ? 16.92644  -3.56896  38.10834  1.000 32.48416  ?  782  ARG A NH2 1 
ATOM   5931 N  N   . TYR A 1 783 ? 20.77895  1.48278   34.01727  1.000 34.38225  ?  783  TYR A N   1 
ATOM   5932 C  CA  . TYR A 1 783 ? 21.01635  2.77560   34.65420  1.000 36.54832  ?  783  TYR A CA  1 
ATOM   5933 C  C   . TYR A 1 783 ? 21.09869  3.89555   33.62780  1.000 36.82367  ?  783  TYR A C   1 
ATOM   5934 O  O   . TYR A 1 783 ? 21.80470  4.88700   33.82904  1.000 40.00669  ?  783  TYR A O   1 
ATOM   5935 C  CB  . TYR A 1 783 ? 22.27912  2.73573   35.51688  1.000 35.50500  ?  783  TYR A CB  1 
ATOM   5936 C  CG  . TYR A 1 783 ? 22.22111  1.62551   36.52076  1.000 38.78883  ?  783  TYR A CG  1 
ATOM   5937 C  CD1 . TYR A 1 783 ? 21.64397  1.81807   37.77964  1.000 36.69654  ?  783  TYR A CD1 1 
ATOM   5938 C  CD2 . TYR A 1 783 ? 22.70520  0.35763   36.19919  1.000 34.74891  ?  783  TYR A CD2 1 
ATOM   5939 C  CE1 . TYR A 1 783 ? 21.58062  0.76157   38.70200  1.000 34.39886  ?  783  TYR A CE1 1 
ATOM   5940 C  CE2 . TYR A 1 783 ? 22.65498  -0.68259  37.10833  1.000 36.09409  ?  783  TYR A CE2 1 
ATOM   5941 C  CZ  . TYR A 1 783 ? 22.08559  -0.48792  38.34918  1.000 36.09232  ?  783  TYR A CZ  1 
ATOM   5942 O  OH  . TYR A 1 783 ? 22.03807  -1.56597  39.21780  1.000 34.07861  ?  783  TYR A OH  1 
ATOM   5943 N  N   . THR A 1 784 ? 20.38310  3.73793   32.52096  1.000 35.56997  ?  784  THR A N   1 
ATOM   5944 C  CA  . THR A 1 784 ? 20.34633  4.72152   31.45403  1.000 37.35277  ?  784  THR A CA  1 
ATOM   5945 C  C   . THR A 1 784 ? 18.94853  5.30844   31.36243  1.000 41.92569  ?  784  THR A C   1 
ATOM   5946 O  O   . THR A 1 784 ? 17.95155  4.59354   31.51602  1.000 35.91986  ?  784  THR A O   1 
ATOM   5947 C  CB  . THR A 1 784 ? 20.71912  4.10983   30.09316  1.000 43.63975  ?  784  THR A CB  1 
ATOM   5948 O  OG1 . THR A 1 784 ? 22.07770  3.64350   30.10875  1.000 42.78738  ?  784  THR A OG1 1 
ATOM   5949 C  CG2 . THR A 1 784 ? 20.57069  5.14456   28.99396  1.000 45.22918  ?  784  THR A CG2 1 
ATOM   5950 N  N   . ILE A 1 785 ? 18.89006  6.61723   31.13739  1.000 35.48645  ?  785  ILE A N   1 
ATOM   5951 C  CA  . ILE A 1 785 ? 17.69478  7.27120   30.64670  1.000 38.54583  ?  785  ILE A CA  1 
ATOM   5952 C  C   . ILE A 1 785 ? 18.04051  7.93459   29.31879  1.000 45.83992  ?  785  ILE A C   1 
ATOM   5953 O  O   . ILE A 1 785 ? 19.20232  8.17488   28.99407  1.000 43.15705  ?  785  ILE A O   1 
ATOM   5954 C  CB  . ILE A 1 785 ? 17.16179  8.29774   31.64717  1.000 42.50374  ?  785  ILE A CB  1 
ATOM   5955 C  CG1 . ILE A 1 785 ? 18.19422  9.41350   31.79832  1.000 39.65515  ?  785  ILE A CG1 1 
ATOM   5956 C  CG2 . ILE A 1 785 ? 16.83264  7.62276   32.99010  1.000 37.22321  ?  785  ILE A CG2 1 
ATOM   5957 C  CD1 . ILE A 1 785 ? 18.00745  10.25211  33.01058  1.000 45.51163  ?  785  ILE A CD1 1 
ATOM   5958 N  N   . THR A 1 786 ? 17.01861  8.23768   28.54370  1.000 46.77746  ?  786  THR A N   1 
ATOM   5959 C  CA  . THR A 1 786 ? 17.21204  8.99655   27.32072  1.000 53.07891  ?  786  THR A CA  1 
ATOM   5960 C  C   . THR A 1 786 ? 16.63754  10.39264  27.49601  1.000 56.65120  ?  786  THR A C   1 
ATOM   5961 O  O   . THR A 1 786 ? 15.56565  10.56945  28.08635  1.000 56.39197  ?  786  THR A O   1 
ATOM   5962 C  CB  . THR A 1 786 ? 16.56358  8.31556   26.11381  1.000 56.51956  ?  786  THR A CB  1 
ATOM   5963 O  OG1 . THR A 1 786 ? 15.17305  8.65085   26.08397  1.000 62.93241  ?  786  THR A OG1 1 
ATOM   5964 C  CG2 . THR A 1 786 ? 16.74687  6.79808   26.14802  1.000 44.48721  ?  786  THR A CG2 1 
ATOM   5965 N  N   . VAL A 1 787 ? 17.37548  11.38298  27.00509  1.000 61.80464  ?  787  VAL A N   1 
ATOM   5966 C  CA  . VAL A 1 787 ? 16.88661  12.75385  26.98182  1.000 66.26301  ?  787  VAL A CA  1 
ATOM   5967 C  C   . VAL A 1 787 ? 16.92588  13.27227  25.54953  1.000 74.60686  ?  787  VAL A C   1 
ATOM   5968 O  O   . VAL A 1 787 ? 17.33626  12.55770  24.61623  1.000 71.68854  ?  787  VAL A O   1 
ATOM   5969 C  CB  . VAL A 1 787 ? 17.68567  13.66988  27.92337  1.000 65.47232  ?  787  VAL A CB  1 
ATOM   5970 C  CG1 . VAL A 1 787 ? 17.85439  13.02372  29.28741  1.000 61.94287  ?  787  VAL A CG1 1 
ATOM   5971 C  CG2 . VAL A 1 787 ? 19.02934  14.01628  27.30315  1.000 71.05532  ?  787  VAL A CG2 1 
ATOM   5972 N  N   . TYR A 1 788 ? 16.47950  14.51543  25.37219  1.000 74.33596  ?  788  TYR A N   1 
ATOM   5973 C  CA  . TYR A 1 788 ? 16.40382  15.13707  24.06178  1.000 78.15295  ?  788  TYR A CA  1 
ATOM   5974 C  C   . TYR A 1 788 ? 17.66786  15.94034  23.80541  1.000 84.08365  ?  788  TYR A C   1 
ATOM   5975 O  O   . TYR A 1 788 ? 18.08851  16.73032  24.65991  1.000 89.22457  ?  788  TYR A O   1 
ATOM   5976 C  CB  . TYR A 1 788 ? 15.16807  16.02692  23.94787  1.000 85.57222  ?  788  TYR A CB  1 
ATOM   5977 C  CG  . TYR A 1 788 ? 13.92133  15.29583  23.49661  1.000 79.85984  ?  788  TYR A CG  1 
ATOM   5978 C  CD1 . TYR A 1 788 ? 13.98966  14.01637  22.94937  1.000 75.12200  ?  788  TYR A CD1 1 
ATOM   5979 C  CD2 . TYR A 1 788 ? 12.67069  15.88715  23.63123  1.000 80.27743  ?  788  TYR A CD2 1 
ATOM   5980 C  CE1 . TYR A 1 788 ? 12.83445  13.35192  22.54568  1.000 76.42052  ?  788  TYR A CE1 1 
ATOM   5981 C  CE2 . TYR A 1 788 ? 11.51693  15.23389  23.23426  1.000 75.43746  ?  788  TYR A CE2 1 
ATOM   5982 C  CZ  . TYR A 1 788 ? 11.59992  13.97628  22.69407  1.000 70.70457  ?  788  TYR A CZ  1 
ATOM   5983 O  OH  . TYR A 1 788 ? 10.43060  13.36406  22.31456  1.000 59.72220  ?  788  TYR A OH  1 
ATOM   5984 N  N   . GLU A 1 789 ? 18.26221  15.73974  22.61998  1.000 83.94993  ?  789  GLU A N   1 
ATOM   5985 C  CA  . GLU A 1 789 ? 19.46431  16.47262  22.22945  1.000 89.30991  ?  789  GLU A CA  1 
ATOM   5986 C  C   . GLU A 1 789 ? 19.34756  17.96915  22.50648  1.000 94.49997  ?  789  GLU A C   1 
ATOM   5987 O  O   . GLU A 1 789 ? 20.37127  18.63181  22.71839  1.000 96.18646  ?  789  GLU A O   1 
ATOM   5988 C  CB  . GLU A 1 789 ? 19.76434  16.21172  20.74550  1.000 88.94245  ?  789  GLU A CB  1 
ATOM   5989 C  CG  . GLU A 1 789 ? 19.25069  17.28325  19.78204  1.000 95.55760  ?  789  GLU A CG  1 
ATOM   5990 C  CD  . GLU A 1 789 ? 19.81238  17.14319  18.36792  1.000 97.34139  ?  789  GLU A CD  1 
ATOM   5991 O  OE1 . GLU A 1 789 ? 20.28242  16.03891  18.01234  1.000 94.74718  ?  789  GLU A OE1 1 
ATOM   5992 O  OE2 . GLU A 1 789 ? 19.78075  18.13971  17.60996  1.000 97.61887  -1 789  GLU A OE2 1 
ATOM   5993 N  N   . HIS A 1 790 ? 18.11905  18.50094  22.54411  1.000 99.63744  ?  790  HIS A N   1 
ATOM   5994 C  CA  . HIS A 1 790 ? 17.89326  19.91829  22.81741  1.000 96.58930  ?  790  HIS A CA  1 
ATOM   5995 C  C   . HIS A 1 790 ? 18.46903  20.32556  24.17084  1.000 94.96010  ?  790  HIS A C   1 
ATOM   5996 O  O   . HIS A 1 790 ? 19.28217  21.25126  24.26535  1.000 97.69434  ?  790  HIS A O   1 
ATOM   5997 C  CB  . HIS A 1 790 ? 16.39179  20.21425  22.76597  1.000 97.80568  ?  790  HIS A CB  1 
ATOM   5998 C  CG  . HIS A 1 790 ? 15.93011  20.81531  21.47449  1.000 102.73409 ?  790  HIS A CG  1 
ATOM   5999 N  ND1 . HIS A 1 790 ? 16.32648  22.06595  21.04888  1.000 102.07238 ?  790  HIS A ND1 1 
ATOM   6000 C  CD2 . HIS A 1 790 ? 15.08940  20.34377  20.52317  1.000 107.71464 ?  790  HIS A CD2 1 
ATOM   6001 C  CE1 . HIS A 1 790 ? 15.75479  22.33617  19.88849  1.000 105.97078 ?  790  HIS A CE1 1 
ATOM   6002 N  NE2 . HIS A 1 790 ? 14.99980  21.30727  19.54649  1.000 110.79153 ?  790  HIS A NE2 1 
ATOM   6003 N  N   . GLU A 1 791 ? 18.06867  19.64120  25.23212  1.000 93.21620  ?  791  GLU A N   1 
ATOM   6004 C  CA  . GLU A 1 791 ? 18.60730  19.96679  26.53991  1.000 91.92570  ?  791  GLU A CA  1 
ATOM   6005 C  C   . GLU A 1 791 ? 19.75174  19.00410  26.83718  1.000 95.08039  ?  791  GLU A C   1 
ATOM   6006 O  O   . GLU A 1 791 ? 20.89208  19.23971  26.43005  1.000 96.71865  ?  791  GLU A O   1 
ATOM   6007 C  CB  . GLU A 1 791 ? 17.51445  19.90719  27.61526  1.000 86.11423  ?  791  GLU A CB  1 
ATOM   6008 C  CG  . GLU A 1 791 ? 18.01718  19.65670  29.03817  1.000 89.96867  ?  791  GLU A CG  1 
ATOM   6009 C  CD  . GLU A 1 791 ? 19.20050  20.53748  29.43806  1.000 97.92386  ?  791  GLU A CD  1 
ATOM   6010 O  OE1 . GLU A 1 791 ? 18.96547  21.69655  29.84296  1.000 99.79691  ?  791  GLU A OE1 1 
ATOM   6011 O  OE2 . GLU A 1 791 ? 20.36467  20.07381  29.33729  1.000 95.11280  -1 791  GLU A OE2 1 
ATOM   6012 N  N   . LEU A 1 795 ? 21.02027  23.99408  30.79804  1.000 77.58072  ?  795  LEU A N   1 
ATOM   6013 C  CA  . LEU A 1 795 ? 22.04722  23.11556  30.24921  1.000 85.39366  ?  795  LEU A CA  1 
ATOM   6014 C  C   . LEU A 1 795 ? 23.41635  23.34991  30.90679  1.000 88.09312  ?  795  LEU A C   1 
ATOM   6015 O  O   . LEU A 1 795 ? 24.36659  23.74584  30.23120  1.000 88.59477  ?  795  LEU A O   1 
ATOM   6016 C  CB  . LEU A 1 795 ? 22.16901  23.32413  28.73555  1.000 82.46382  ?  795  LEU A CB  1 
ATOM   6017 C  CG  . LEU A 1 795 ? 21.09605  22.83919  27.76010  1.000 84.15692  ?  795  LEU A CG  1 
ATOM   6018 C  CD1 . LEU A 1 795 ? 20.11832  23.95101  27.44879  1.000 84.33669  ?  795  LEU A CD1 1 
ATOM   6019 C  CD2 . LEU A 1 795 ? 21.73347  22.32441  26.47564  1.000 84.39830  ?  795  LEU A CD2 1 
ATOM   6020 N  N   . PRO A 1 796 ? 23.53120  23.08011  32.20767  1.000 85.77548  ?  796  PRO A N   1 
ATOM   6021 C  CA  . PRO A 1 796 ? 24.74913  23.46642  32.94112  1.000 84.82153  ?  796  PRO A CA  1 
ATOM   6022 C  C   . PRO A 1 796 ? 26.00060  22.74140  32.44758  1.000 86.12073  ?  796  PRO A C   1 
ATOM   6023 O  O   . PRO A 1 796 ? 25.93703  21.71476  31.76702  1.000 83.14925  ?  796  PRO A O   1 
ATOM   6024 C  CB  . PRO A 1 796 ? 24.42305  23.09350  34.39474  1.000 77.43798  ?  796  PRO A CB  1 
ATOM   6025 C  CG  . PRO A 1 796 ? 22.92177  22.99505  34.43403  1.000 78.63507  ?  796  PRO A CG  1 
ATOM   6026 C  CD  . PRO A 1 796 ? 22.52507  22.47177  33.09097  1.000 80.71072  ?  796  PRO A CD  1 
ATOM   6027 N  N   . GLU A 1 797 ? 27.16143  23.29296  32.82747  1.000 86.59426  ?  797  GLU A N   1 
ATOM   6028 C  CA  . GLU A 1 797 ? 28.43884  22.93540  32.20597  1.000 85.84473  ?  797  GLU A CA  1 
ATOM   6029 C  C   . GLU A 1 797 ? 28.95431  21.57439  32.66114  1.000 84.06532  ?  797  GLU A C   1 
ATOM   6030 O  O   . GLU A 1 797 ? 29.25663  20.70375  31.83525  1.000 84.64107  ?  797  GLU A O   1 
ATOM   6031 C  CB  . GLU A 1 797 ? 29.49111  24.01131  32.49869  1.000 90.44810  ?  797  GLU A CB  1 
ATOM   6032 C  CG  . GLU A 1 797 ? 30.71403  23.93770  31.57760  1.000 91.61102  ?  797  GLU A CG  1 
ATOM   6033 C  CD  . GLU A 1 797 ? 32.02581  23.79519  32.33537  1.000 91.25519  ?  797  GLU A CD  1 
ATOM   6034 O  OE1 . GLU A 1 797 ? 32.05386  24.11283  33.54307  1.000 92.40338  ?  797  GLU A OE1 1 
ATOM   6035 O  OE2 . GLU A 1 797 ? 33.02983  23.36372  31.72512  1.000 89.15035  -1 797  GLU A OE2 1 
ATOM   6036 N  N   . HIS A 1 798 ? 29.11470  21.39128  33.96679  1.000 83.34273  ?  798  HIS A N   1 
ATOM   6037 C  CA  . HIS A 1 798 ? 29.58657  20.12178  34.50252  1.000 83.16669  ?  798  HIS A CA  1 
ATOM   6038 C  C   . HIS A 1 798 ? 28.44694  19.20033  34.90208  1.000 76.29998  ?  798  HIS A C   1 
ATOM   6039 O  O   . HIS A 1 798 ? 28.68393  18.19355  35.58097  1.000 74.30026  ?  798  HIS A O   1 
ATOM   6040 C  CB  . HIS A 1 798 ? 30.51508  20.36236  35.69206  1.000 84.67278  ?  798  HIS A CB  1 
ATOM   6041 C  CG  . HIS A 1 798 ? 31.94154  20.54501  35.29284  1.000 89.73513  ?  798  HIS A CG  1 
ATOM   6042 N  ND1 . HIS A 1 798 ? 32.30567  21.22736  34.15145  1.000 90.55894  ?  798  HIS A ND1 1 
ATOM   6043 C  CD2 . HIS A 1 798 ? 33.09281  20.11520  35.85932  1.000 93.05886  ?  798  HIS A CD2 1 
ATOM   6044 C  CE1 . HIS A 1 798 ? 33.62126  21.22269  34.03867  1.000 89.45508  ?  798  HIS A CE1 1 
ATOM   6045 N  NE2 . HIS A 1 798 ? 34.12304  20.55311  35.06120  1.000 97.57265  ?  798  HIS A NE2 1 
ATOM   6046 N  N   . ALA A 1 799 ? 27.21835  19.53788  34.50695  1.000 75.19656  ?  799  ALA A N   1 
ATOM   6047 C  CA  . ALA A 1 799 ? 26.07884  18.66796  34.76366  1.000 72.97249  ?  799  ALA A CA  1 
ATOM   6048 C  C   . ALA A 1 799 ? 26.27637  17.30565  34.11424  1.000 70.11193  ?  799  ALA A C   1 
ATOM   6049 O  O   . ALA A 1 799 ? 25.93737  16.26911  34.69894  1.000 65.05765  ?  799  ALA A O   1 
ATOM   6050 C  CB  . ALA A 1 799 ? 24.80244  19.32831  34.24527  1.000 72.21706  ?  799  ALA A CB  1 
ATOM   6051 N  N   . VAL A 1 800 ? 26.81917  17.28965  32.90192  1.000 71.89660  ?  800  VAL A N   1 
ATOM   6052 C  CA  . VAL A 1 800 ? 27.06683  16.06390  32.15784  1.000 65.26524  ?  800  VAL A CA  1 
ATOM   6053 C  C   . VAL A 1 800 ? 28.54446  15.99739  31.83720  1.000 63.85631  ?  800  VAL A C   1 
ATOM   6054 O  O   . VAL A 1 800 ? 29.11794  16.96967  31.33568  1.000 66.14500  ?  800  VAL A O   1 
ATOM   6055 C  CB  . VAL A 1 800 ? 26.23986  16.00355  30.86553  1.000 58.69178  ?  800  VAL A CB  1 
ATOM   6056 C  CG1 . VAL A 1 800 ? 26.39545  14.63145  30.18989  1.000 55.59923  ?  800  VAL A CG1 1 
ATOM   6057 C  CG2 . VAL A 1 800 ? 24.80053  16.30784  31.17130  1.000 61.93540  ?  800  VAL A CG2 1 
ATOM   6058 N  N   . PHE A 1 801 ? 29.15632  14.85521  32.11859  1.000 63.05034  ?  801  PHE A N   1 
ATOM   6059 C  CA  . PHE A 1 801 ? 30.53817  14.63806  31.72293  1.000 61.37444  ?  801  PHE A CA  1 
ATOM   6060 C  C   . PHE A 1 801 ? 30.65150  13.33286  30.95135  1.000 61.86622  ?  801  PHE A C   1 
ATOM   6061 O  O   . PHE A 1 801 ? 29.68080  12.58454  30.78751  1.000 59.72963  ?  801  PHE A O   1 
ATOM   6062 C  CB  . PHE A 1 801 ? 31.48807  14.63276  32.92117  1.000 53.34931  ?  801  PHE A CB  1 
ATOM   6063 C  CG  . PHE A 1 801 ? 31.10227  13.68105  34.00615  1.000 56.49981  ?  801  PHE A CG  1 
ATOM   6064 C  CD1 . PHE A 1 801 ? 30.03387  13.96357  34.85011  1.000 53.82313  ?  801  PHE A CD1 1 
ATOM   6065 C  CD2 . PHE A 1 801 ? 31.82772  12.51733  34.20884  1.000 50.95516  ?  801  PHE A CD2 1 
ATOM   6066 C  CE1 . PHE A 1 801 ? 29.69260  13.09547  35.87003  1.000 55.61850  ?  801  PHE A CE1 1 
ATOM   6067 C  CE2 . PHE A 1 801 ? 31.48757  11.64112  35.22420  1.000 53.24644  ?  801  PHE A CE2 1 
ATOM   6068 C  CZ  . PHE A 1 801 ? 30.41744  11.93036  36.05730  1.000 52.21102  ?  801  PHE A CZ  1 
ATOM   6069 N  N   . SER A 1 802 ? 31.85332  13.08782  30.44656  1.000 57.25111  ?  802  SER A N   1 
ATOM   6070 C  CA  . SER A 1 802 ? 32.15700  11.89790  29.67375  1.000 56.68886  ?  802  SER A CA  1 
ATOM   6071 C  C   . SER A 1 802 ? 33.04100  10.99005  30.51361  1.000 51.82626  ?  802  SER A C   1 
ATOM   6072 O  O   . SER A 1 802 ? 33.78243  11.45063  31.38200  1.000 59.98027  ?  802  SER A O   1 
ATOM   6073 C  CB  . SER A 1 802 ? 32.83775  12.26440  28.34454  1.000 60.53641  ?  802  SER A CB  1 
ATOM   6074 O  OG  . SER A 1 802 ? 33.31743  11.12241  27.65706  1.000 55.37482  ?  802  SER A OG  1 
ATOM   6075 N  N   . ARG A 1 803 ? 32.91910  9.69292   30.28199  1.000 47.44818  ?  803  ARG A N   1 
ATOM   6076 C  CA  . ARG A 1 803 ? 33.71297  8.71934   31.01200  1.000 52.63170  ?  803  ARG A CA  1 
ATOM   6077 C  C   . ARG A 1 803 ? 33.62594  7.37187   30.30973  1.000 47.66757  ?  803  ARG A C   1 
ATOM   6078 O  O   . ARG A 1 803 ? 32.52392  6.89835   29.99979  1.000 44.48121  ?  803  ARG A O   1 
ATOM   6079 C  CB  . ARG A 1 803 ? 33.24080  8.61666   32.45989  1.000 51.69851  ?  803  ARG A CB  1 
ATOM   6080 C  CG  . ARG A 1 803 ? 33.96955  7.57320   33.24900  1.000 53.05127  ?  803  ARG A CG  1 
ATOM   6081 C  CD  . ARG A 1 803 ? 34.90704  8.19719   34.24441  1.000 48.76465  ?  803  ARG A CD  1 
ATOM   6082 N  NE  . ARG A 1 803 ? 35.76440  7.17802   34.83906  1.000 52.23649  ?  803  ARG A NE  1 
ATOM   6083 C  CZ  . ARG A 1 803 ? 35.62046  6.68423   36.06175  1.000 47.02973  ?  803  ARG A CZ  1 
ATOM   6084 N  NH1 . ARG A 1 803 ? 34.68708  7.13097   36.88175  1.000 50.52317  ?  803  ARG A NH1 1 
ATOM   6085 N  NH2 . ARG A 1 803 ? 36.42415  5.70389   36.46459  1.000 39.89853  ?  803  ARG A NH2 1 
ATOM   6086 N  N   . ALA A 1 804 ? 34.78365  6.75955   30.04981  1.000 47.56718  ?  804  ALA A N   1 
ATOM   6087 C  CA  . ALA A 1 804 ? 34.87210  5.51545   29.28335  1.000 44.50012  ?  804  ALA A CA  1 
ATOM   6088 C  C   . ALA A 1 804 ? 34.20660  5.66490   27.92186  1.000 43.49049  ?  804  ALA A C   1 
ATOM   6089 O  O   . ALA A 1 804 ? 33.65469  4.70341   27.38274  1.000 42.40318  ?  804  ALA A O   1 
ATOM   6090 C  CB  . ALA A 1 804 ? 34.26397  4.33928   30.05251  1.000 38.23360  ?  804  ALA A CB  1 
ATOM   6091 N  N   . GLY A 1 805 ? 34.21982  6.88259   27.37316  1.000 39.83953  ?  805  GLY A N   1 
ATOM   6092 C  CA  . GLY A 1 805 ? 33.54675  7.16410   26.12041  1.000 42.89965  ?  805  GLY A CA  1 
ATOM   6093 C  C   . GLY A 1 805 ? 32.03605  7.29865   26.19681  1.000 44.40153  ?  805  GLY A C   1 
ATOM   6094 O  O   . GLY A 1 805 ? 31.40158  7.51870   25.15699  1.000 47.46658  ?  805  GLY A O   1 
ATOM   6095 N  N   . LEU A 1 806 ? 31.44038  7.18224   27.38255  1.000 40.68159  ?  806  LEU A N   1 
ATOM   6096 C  CA  . LEU A 1 806 ? 29.99919  7.25146   27.57462  1.000 45.09549  ?  806  LEU A CA  1 
ATOM   6097 C  C   . LEU A 1 806 ? 29.62112  8.51577   28.33263  1.000 44.87028  ?  806  LEU A C   1 
ATOM   6098 O  O   . LEU A 1 806 ? 30.37867  9.01063   29.17090  1.000 43.62887  ?  806  LEU A O   1 
ATOM   6099 C  CB  . LEU A 1 806 ? 29.48590  6.03553   28.35068  1.000 42.59078  ?  806  LEU A CB  1 
ATOM   6100 C  CG  . LEU A 1 806 ? 29.90681  4.70537   27.73894  1.000 42.43735  ?  806  LEU A CG  1 
ATOM   6101 C  CD1 . LEU A 1 806 ? 29.67334  3.56734   28.71159  1.000 42.85344  ?  806  LEU A CD1 1 
ATOM   6102 C  CD2 . LEU A 1 806 ? 29.15035  4.49010   26.44229  1.000 40.07743  ?  806  LEU A CD2 1 
ATOM   6103 N  N   . LEU A 1 807 ? 28.42535  9.01836   28.04777  1.000 46.91984  ?  807  LEU A N   1 
ATOM   6104 C  CA  . LEU A 1 807 ? 27.92529  10.21319  28.70992  1.000 50.87428  ?  807  LEU A CA  1 
ATOM   6105 C  C   . LEU A 1 807 ? 27.29898  9.82324   30.04475  1.000 49.24108  ?  807  LEU A C   1 
ATOM   6106 O  O   . LEU A 1 807 ? 26.61606  8.79654   30.14499  1.000 39.71592  ?  807  LEU A O   1 
ATOM   6107 C  CB  . LEU A 1 807 ? 26.91082  10.92952  27.81582  1.000 49.39549  ?  807  LEU A CB  1 
ATOM   6108 C  CG  . LEU A 1 807 ? 27.43551  11.80724  26.65941  1.000 54.55119  ?  807  LEU A CG  1 
ATOM   6109 C  CD1 . LEU A 1 807 ? 28.09109  13.06211  27.19697  1.000 50.55930  ?  807  LEU A CD1 1 
ATOM   6110 C  CD2 . LEU A 1 807 ? 28.40500  11.07626  25.70144  1.000 55.33548  ?  807  LEU A CD2 1 
ATOM   6111 N  N   . VAL A 1 808 ? 27.56255  10.63456  31.07528  1.000 46.24107  ?  808  VAL A N   1 
ATOM   6112 C  CA  . VAL A 1 808 ? 27.12982  10.37116  32.44463  1.000 47.83240  ?  808  VAL A CA  1 
ATOM   6113 C  C   . VAL A 1 808 ? 26.60861  11.66654  33.04940  1.000 50.99439  ?  808  VAL A C   1 
ATOM   6114 O  O   . VAL A 1 808 ? 27.16077  12.74274  32.79622  1.000 54.05867  ?  808  VAL A O   1 
ATOM   6115 C  CB  . VAL A 1 808 ? 28.28221  9.81603   33.30746  1.000 46.02815  ?  808  VAL A CB  1 
ATOM   6116 C  CG1 . VAL A 1 808 ? 27.80636  9.52709   34.72197  1.000 44.38275  ?  808  VAL A CG1 1 
ATOM   6117 C  CG2 . VAL A 1 808 ? 28.87894  8.58485   32.67497  1.000 45.25567  ?  808  VAL A CG2 1 
ATOM   6118 N  N   . LEU A 1 809 ? 25.55558  11.56554  33.86286  1.000 50.96892  ?  809  LEU A N   1 
ATOM   6119 C  CA  . LEU A 1 809 ? 25.03588  12.70062  34.62191  1.000 51.61993  ?  809  LEU A CA  1 
ATOM   6120 C  C   . LEU A 1 809 ? 25.59232  12.69465  36.03559  1.000 51.76882  ?  809  LEU A C   1 
ATOM   6121 O  O   . LEU A 1 809 ? 25.60865  11.65417  36.69962  1.000 50.70696  ?  809  LEU A O   1 
ATOM   6122 C  CB  . LEU A 1 809 ? 23.51287  12.67303  34.70228  1.000 54.03934  ?  809  LEU A CB  1 
ATOM   6123 C  CG  . LEU A 1 809 ? 22.75856  13.93675  35.10442  1.000 53.13687  ?  809  LEU A CG  1 
ATOM   6124 C  CD1 . LEU A 1 809 ? 22.33095  14.68086  33.86962  1.000 55.31307  ?  809  LEU A CD1 1 
ATOM   6125 C  CD2 . LEU A 1 809 ? 21.55148  13.52654  35.90150  1.000 52.41758  ?  809  LEU A CD2 1 
ATOM   6126 N  N   . ASP A 1 810 ? 26.02363  13.86599  36.50074  1.000 55.52197  ?  810  ASP A N   1 
ATOM   6127 C  CA  . ASP A 1 810 ? 26.49717  13.99366  37.87371  1.000 58.51755  ?  810  ASP A CA  1 
ATOM   6128 C  C   . ASP A 1 810 ? 25.35375  13.77481  38.85930  1.000 55.60199  ?  810  ASP A C   1 
ATOM   6129 O  O   . ASP A 1 810 ? 24.22809  14.23734  38.64180  1.000 55.86311  ?  810  ASP A O   1 
ATOM   6130 C  CB  . ASP A 1 810 ? 27.12061  15.36897  38.10679  1.000 62.70842  ?  810  ASP A CB  1 
ATOM   6131 C  CG  . ASP A 1 810 ? 27.30713  15.67506  39.58446  1.000 66.95086  ?  810  ASP A CG  1 
ATOM   6132 O  OD1 . ASP A 1 810 ? 28.17002  15.02803  40.22707  1.000 68.66320  ?  810  ASP A OD1 1 
ATOM   6133 O  OD2 . ASP A 1 810 ? 26.56562  16.53544  40.11332  1.000 68.50478  -1 810  ASP A OD2 1 
ATOM   6134 N  N   . LYS A 1 811 ? 25.67008  13.10244  39.97135  1.000 49.31564  ?  811  LYS A N   1 
ATOM   6135 C  CA  . LYS A 1 811 ? 24.64838  12.62991  40.90571  1.000 61.41441  ?  811  LYS A CA  1 
ATOM   6136 C  C   . LYS A 1 811 ? 23.78285  13.76477  41.44529  1.000 59.85232  ?  811  LYS A C   1 
ATOM   6137 O  O   . LYS A 1 811 ? 22.63439  13.53498  41.84194  1.000 51.40738  ?  811  LYS A O   1 
ATOM   6138 C  CB  . LYS A 1 811 ? 25.31528  11.89144  42.06615  1.000 63.19040  ?  811  LYS A CB  1 
ATOM   6139 C  CG  . LYS A 1 811 ? 26.37740  12.73566  42.76371  1.000 62.59288  ?  811  LYS A CG  1 
ATOM   6140 C  CD  . LYS A 1 811 ? 27.44619  11.88314  43.41975  1.000 64.00287  ?  811  LYS A CD  1 
ATOM   6141 C  CE  . LYS A 1 811 ? 28.76005  12.65669  43.48893  1.000 70.52565  ?  811  LYS A CE  1 
ATOM   6142 N  NZ  . LYS A 1 811 ? 29.56563  12.49591  42.22761  1.000 69.81073  ?  811  LYS A NZ  1 
ATOM   6143 N  N   . GLY A 1 812 ? 24.30953  14.99158  41.47009  1.000 64.27557  ?  812  GLY A N   1 
ATOM   6144 C  CA  . GLY A 1 812 ? 23.54955  16.10284  42.00464  1.000 57.43908  ?  812  GLY A CA  1 
ATOM   6145 C  C   . GLY A 1 812 ? 22.30544  16.41332  41.20916  1.000 61.09241  ?  812  GLY A C   1 
ATOM   6146 O  O   . GLY A 1 812 ? 21.40755  17.08992  41.72071  1.000 67.74440  ?  812  GLY A O   1 
ATOM   6147 N  N   . TYR A 1 813 ? 22.22293  15.91877  39.97494  1.000 56.92368  ?  813  TYR A N   1 
ATOM   6148 C  CA  . TYR A 1 813 ? 21.15124  16.26131  39.05409  1.000 56.40365  ?  813  TYR A CA  1 
ATOM   6149 C  C   . TYR A 1 813 ? 20.10700  15.16349  38.92451  1.000 52.17967  ?  813  TYR A C   1 
ATOM   6150 O  O   . TYR A 1 813 ? 19.27478  15.22193  38.01551  1.000 51.05727  ?  813  TYR A O   1 
ATOM   6151 C  CB  . TYR A 1 813 ? 21.72288  16.57941  37.67551  1.000 57.66927  ?  813  TYR A CB  1 
ATOM   6152 C  CG  . TYR A 1 813 ? 22.27798  17.97224  37.53749  1.000 66.07419  ?  813  TYR A CG  1 
ATOM   6153 C  CD1 . TYR A 1 813 ? 23.29255  18.41742  38.37615  1.000 68.65122  ?  813  TYR A CD1 1 
ATOM   6154 C  CD2 . TYR A 1 813 ? 21.79831  18.84024  36.56023  1.000 69.61102  ?  813  TYR A CD2 1 
ATOM   6155 C  CE1 . TYR A 1 813 ? 23.80886  19.69103  38.25639  1.000 72.61905  ?  813  TYR A CE1 1 
ATOM   6156 C  CE2 . TYR A 1 813 ? 22.30396  20.12039  36.43333  1.000 73.16596  ?  813  TYR A CE2 1 
ATOM   6157 C  CZ  . TYR A 1 813 ? 23.31464  20.53972  37.28621  1.000 75.63363  ?  813  TYR A CZ  1 
ATOM   6158 O  OH  . TYR A 1 813 ? 23.84492  21.80770  37.18037  1.000 79.92187  ?  813  TYR A OH  1 
ATOM   6159 N  N   . TYR A 1 814 ? 20.14105  14.16445  39.79642  1.000 49.32528  ?  814  TYR A N   1 
ATOM   6160 C  CA  . TYR A 1 814 ? 19.23991  13.01798  39.73338  1.000 46.22568  ?  814  TYR A CA  1 
ATOM   6161 C  C   . TYR A 1 814 ? 18.68931  12.78995  41.12992  1.000 46.99656  ?  814  TYR A C   1 
ATOM   6162 O  O   . TYR A 1 814 ? 19.43090  12.39308  42.03646  1.000 41.58767  ?  814  TYR A O   1 
ATOM   6163 C  CB  . TYR A 1 814 ? 19.96306  11.77282  39.23058  1.000 38.59975  ?  814  TYR A CB  1 
ATOM   6164 C  CG  . TYR A 1 814 ? 19.06114  10.59715  38.96403  1.000 46.38665  ?  814  TYR A CG  1 
ATOM   6165 C  CD1 . TYR A 1 814 ? 18.67339  9.73846   39.99614  1.000 36.01001  ?  814  TYR A CD1 1 
ATOM   6166 C  CD2 . TYR A 1 814 ? 18.61414  10.32242  37.67400  1.000 39.58019  ?  814  TYR A CD2 1 
ATOM   6167 C  CE1 . TYR A 1 814 ? 17.86738  8.64067   39.74353  1.000 39.71741  ?  814  TYR A CE1 1 
ATOM   6168 C  CE2 . TYR A 1 814 ? 17.79992  9.23091   37.41924  1.000 38.41551  ?  814  TYR A CE2 1 
ATOM   6169 C  CZ  . TYR A 1 814 ? 17.42812  8.39782   38.45687  1.000 37.61231  ?  814  TYR A CZ  1 
ATOM   6170 O  OH  . TYR A 1 814 ? 16.61527  7.32168   38.18998  1.000 32.04478  ?  814  TYR A OH  1 
ATOM   6171 N  N   . LYS A 1 815 ? 17.39472  13.02027  41.30003  1.000 47.38832  ?  815  LYS A N   1 
ATOM   6172 C  CA  . LYS A 1 815 ? 16.80017  13.02907  42.62374  1.000 47.12203  ?  815  LYS A CA  1 
ATOM   6173 C  C   . LYS A 1 815 ? 16.05623  11.72600  42.91019  1.000 44.70942  ?  815  LYS A C   1 
ATOM   6174 O  O   . LYS A 1 815 ? 15.61153  11.01717  42.00193  1.000 43.57801  ?  815  LYS A O   1 
ATOM   6175 C  CB  . LYS A 1 815 ? 15.89665  14.25503  42.76856  1.000 44.22721  ?  815  LYS A CB  1 
ATOM   6176 C  CG  . LYS A 1 815 ? 16.58630  15.52843  42.22765  1.000 52.65958  ?  815  LYS A CG  1 
ATOM   6177 C  CD  . LYS A 1 815 ? 16.00557  15.96257  40.86646  1.000 55.47816  ?  815  LYS A CD  1 
ATOM   6178 C  CE  . LYS A 1 815 ? 16.98055  16.78753  39.99205  1.000 55.71415  ?  815  LYS A CE  1 
ATOM   6179 N  NZ  . LYS A 1 815 ? 16.39584  17.14702  38.64376  1.000 56.00923  ?  815  LYS A NZ  1 
ATOM   6180 N  N   . ALA A 1 816 ? 15.93875  11.41840  44.20157  1.000 39.26608  ?  816  ALA A N   1 
ATOM   6181 C  CA  . ALA A 1 816 ? 15.43120  10.12619  44.63752  1.000 38.99607  ?  816  ALA A CA  1 
ATOM   6182 C  C   . ALA A 1 816 ? 13.98948  9.88344   44.21012  1.000 41.76246  ?  816  ALA A C   1 
ATOM   6183 O  O   . ALA A 1 816 ? 13.58220  8.72409   44.04403  1.000 40.93034  ?  816  ALA A O   1 
ATOM   6184 C  CB  . ALA A 1 816 ? 15.54357  10.01686  46.15765  1.000 44.17084  ?  816  ALA A CB  1 
ATOM   6185 N  N   . VAL A 1 817 ? 13.18952  10.93592  44.06843  1.000 40.06917  ?  817  VAL A N   1 
ATOM   6186 C  CA  . VAL A 1 817 ? 11.77642  10.78331  43.75709  1.000 36.03293  ?  817  VAL A CA  1 
ATOM   6187 C  C   . VAL A 1 817 ? 11.50818  11.00435  42.27714  1.000 39.20445  ?  817  VAL A C   1 
ATOM   6188 O  O   . VAL A 1 817 ? 10.83186  10.20040  41.63754  1.000 37.19874  ?  817  VAL A O   1 
ATOM   6189 C  CB  . VAL A 1 817 ? 10.91832  11.71513  44.64432  1.000 44.58583  ?  817  VAL A CB  1 
ATOM   6190 C  CG1 . VAL A 1 817 ? 9.47562   11.77464  44.14407  1.000 35.63484  ?  817  VAL A CG1 1 
ATOM   6191 C  CG2 . VAL A 1 817 ? 10.95378  11.23586  46.10350  1.000 39.40967  ?  817  VAL A CG2 1 
ATOM   6192 N  N   . LEU A 1 818 ? 12.07064  12.06487  41.70054  1.000 39.22748  ?  818  LEU A N   1 
ATOM   6193 C  CA  . LEU A 1 818 ? 11.75956  12.44114  40.33059  1.000 42.22747  ?  818  LEU A CA  1 
ATOM   6194 C  C   . LEU A 1 818 ? 12.78625  11.96713  39.30388  1.000 41.80920  ?  818  LEU A C   1 
ATOM   6195 O  O   . LEU A 1 818 ? 12.50429  12.03047  38.10458  1.000 37.80510  ?  818  LEU A O   1 
ATOM   6196 C  CB  . LEU A 1 818 ? 11.61399  13.96596  40.23814  1.000 38.10263  ?  818  LEU A CB  1 
ATOM   6197 C  CG  . LEU A 1 818 ? 10.47687  14.50352  41.10772  1.000 42.15316  ?  818  LEU A CG  1 
ATOM   6198 C  CD1 . LEU A 1 818 ? 10.34387  16.00508  40.94847  1.000 34.73981  ?  818  LEU A CD1 1 
ATOM   6199 C  CD2 . LEU A 1 818 ? 9.14834   13.79358  40.79963  1.000 36.88987  ?  818  LEU A CD2 1 
ATOM   6200 N  N   . GLY A 1 819 ? 13.94928  11.48498  39.73294  1.000 42.37793  ?  819  GLY A N   1 
ATOM   6201 C  CA  . GLY A 1 819 ? 15.02883  11.25872  38.78026  1.000 39.85835  ?  819  GLY A CA  1 
ATOM   6202 C  C   . GLY A 1 819 ? 15.56624  12.57326  38.24257  1.000 44.69500  ?  819  GLY A C   1 
ATOM   6203 O  O   . GLY A 1 819 ? 15.68085  13.57098  38.96172  1.000 48.79053  ?  819  GLY A O   1 
ATOM   6204 N  N   . ALA A 1 820 ? 15.89013  12.59278  36.95794  1.000 41.63075  ?  820  ALA A N   1 
ATOM   6205 C  CA  . ALA A 1 820 ? 16.45214  13.79027  36.35214  1.000 42.38043  ?  820  ALA A CA  1 
ATOM   6206 C  C   . ALA A 1 820 ? 15.33304  14.78334  35.99869  1.000 48.48972  ?  820  ALA A C   1 
ATOM   6207 O  O   . ALA A 1 820 ? 14.16492  14.61204  36.35940  1.000 52.65026  ?  820  ALA A O   1 
ATOM   6208 C  CB  . ALA A 1 820 ? 17.28458  13.40888  35.13116  1.000 43.56722  ?  820  ALA A CB  1 
ATOM   6209 N  N   . ASP A 1 821 ? 15.67868  15.85445  35.28241  1.000 57.14108  ?  821  ASP A N   1 
ATOM   6210 C  CA  . ASP A 1 821 ? 14.70583  16.89934  34.94056  1.000 57.46360  ?  821  ASP A CA  1 
ATOM   6211 C  C   . ASP A 1 821 ? 14.71756  17.22648  33.46027  1.000 53.19010  ?  821  ASP A C   1 
ATOM   6212 O  O   . ASP A 1 821 ? 13.83544  16.80284  32.71823  1.000 58.25920  ?  821  ASP A O   1 
ATOM   6213 C  CB  . ASP A 1 821 ? 14.96466  18.17802  35.74874  1.000 59.22749  ?  821  ASP A CB  1 
ATOM   6214 C  CG  . ASP A 1 821 ? 13.66682  18.92384  36.09087  1.000 65.66466  ?  821  ASP A CG  1 
ATOM   6215 O  OD1 . ASP A 1 821 ? 13.60813  20.16568  35.92818  1.000 57.93567  -1 821  ASP A OD1 1 
ATOM   6216 O  OD2 . ASP A 1 821 ? 12.70406  18.25985  36.53681  1.000 66.69608  -1 821  ASP A OD2 1 
HETATM 6217 FE FE  . FE  B 2 .   ? 39.13349  -3.12529  7.68819   1.000 28.66699  3  901  FE  A FE  1 
HETATM 6218 FE FE  . FE  C 2 .   ? 38.87229  -7.46967  8.74624   1.000 28.83768  3  902  FE  A FE  1 
HETATM 6219 O  O   . HOH D 3 .   ? 22.13412  13.67645  8.74760   1.000 55.72411  ?  1001 HOH A O   1 
HETATM 6220 O  O   . HOH D 3 .   ? 17.67026  -2.47480  43.23827  1.000 39.70811  ?  1002 HOH A O   1 
HETATM 6221 O  O   . HOH D 3 .   ? 18.21071  -9.91434  51.64790  1.000 55.68968  ?  1003 HOH A O   1 
HETATM 6222 O  O   . HOH D 3 .   ? 4.10503   20.92268  30.59083  1.000 48.28782  ?  1004 HOH A O   1 
HETATM 6223 O  O   . HOH D 3 .   ? 5.32600   -0.63202  17.71393  1.000 44.13036  ?  1005 HOH A O   1 
HETATM 6224 O  O   . HOH D 3 .   ? 3.71802   10.54171  2.28295   1.000 49.14526  ?  1006 HOH A O   1 
HETATM 6225 O  O   . HOH D 3 .   ? -14.25364 -4.09467  16.66936  1.000 42.19291  ?  1007 HOH A O   1 
HETATM 6226 O  O   . HOH D 3 .   ? 17.05101  12.92685  22.47306  1.000 74.41948  ?  1008 HOH A O   1 
HETATM 6227 O  O   . HOH D 3 .   ? 16.92102  7.81112   17.68286  1.000 55.62464  ?  1009 HOH A O   1 
HETATM 6228 O  O   . HOH D 3 .   ? 32.53075  0.96513   19.57843  1.000 54.53015  ?  1010 HOH A O   1 
HETATM 6229 O  O   . HOH D 3 .   ? 44.39568  -21.31730 -5.41206  1.000 59.69532  ?  1011 HOH A O   1 
HETATM 6230 O  O   . HOH D 3 .   ? 14.77283  15.97437  30.90526  1.000 56.13262  ?  1012 HOH A O   1 
HETATM 6231 O  O   . HOH D 3 .   ? -16.69712 25.88820  26.77502  1.000 47.15473  ?  1013 HOH A O   1 
HETATM 6232 O  O   . HOH D 3 .   ? -16.13143 8.32777   38.59917  1.000 44.62149  ?  1014 HOH A O   1 
HETATM 6233 O  O   . HOH D 3 .   ? -21.78478 -1.00988  24.58387  1.000 52.19667  ?  1015 HOH A O   1 
HETATM 6234 O  O   . HOH D 3 .   ? 13.67105  -18.80456 4.64779   1.000 47.12092  ?  1016 HOH A O   1 
HETATM 6235 O  O   . HOH D 3 .   ? 59.45365  0.09831   -0.01079  1.000 59.54982  ?  1017 HOH A O   1 
HETATM 6236 O  O   . HOH D 3 .   ? -13.50477 -18.60510 25.15364  1.000 65.29425  ?  1018 HOH A O   1 
HETATM 6237 O  O   . HOH D 3 .   ? 18.64209  -11.29480 43.69595  1.000 52.97986  ?  1019 HOH A O   1 
HETATM 6238 O  O   . HOH D 3 .   ? -7.87747  -7.49297  56.07566  1.000 46.73446  ?  1020 HOH A O   1 
HETATM 6239 O  O   . HOH D 3 .   ? 7.33987   -6.23405  38.67085  1.000 48.83701  ?  1021 HOH A O   1 
HETATM 6240 O  O   . HOH D 3 .   ? 29.81655  -8.91483  52.86211  1.000 67.37619  ?  1022 HOH A O   1 
HETATM 6241 O  O   . HOH D 3 .   ? -12.34271 19.39576  31.31588  1.000 40.36053  ?  1023 HOH A O   1 
HETATM 6242 O  O   . HOH D 3 .   ? 34.55376  4.01017   -10.56276 1.000 73.43570  ?  1024 HOH A O   1 
HETATM 6243 O  O   . HOH D 3 .   ? 34.60529  8.35779   51.22869  1.000 64.37425  ?  1025 HOH A O   1 
HETATM 6244 O  O   . HOH D 3 .   ? 36.67076  -16.88345 12.08034  1.000 39.27728  ?  1026 HOH A O   1 
HETATM 6245 O  O   . HOH D 3 .   ? 34.31828  9.49048   36.85369  1.000 54.61140  ?  1027 HOH A O   1 
HETATM 6246 O  O   . HOH D 3 .   ? 16.63387  -2.85894  32.00117  1.000 45.55717  ?  1028 HOH A O   1 
HETATM 6247 O  O   . HOH D 3 .   ? 13.93058  -15.67553 -0.43595  1.000 39.51353  ?  1029 HOH A O   1 
HETATM 6248 O  O   . HOH D 3 .   ? 32.86000  10.69753  42.90437  1.000 72.92403  ?  1030 HOH A O   1 
HETATM 6249 O  O   . HOH D 3 .   ? 24.84333  2.87379   49.93238  1.000 42.49426  ?  1031 HOH A O   1 
HETATM 6250 O  O   . HOH D 3 .   ? -11.27616 -8.69080  18.39070  1.000 43.17542  ?  1032 HOH A O   1 
HETATM 6251 O  O   . HOH D 3 .   ? 0.18300   3.57041   25.84991  1.000 43.72916  ?  1033 HOH A O   1 
HETATM 6252 O  O   . HOH D 3 .   ? -3.33981  -8.17121  50.36159  1.000 41.39204  ?  1034 HOH A O   1 
HETATM 6253 O  O   . HOH D 3 .   ? 0.90288   4.68725   15.83846  1.000 47.87581  ?  1035 HOH A O   1 
HETATM 6254 O  O   . HOH D 3 .   ? -11.76916 15.01394  35.70803  1.000 37.63794  ?  1036 HOH A O   1 
HETATM 6255 O  O   . HOH D 3 .   ? 14.35005  7.64192   29.74636  1.000 41.74918  ?  1037 HOH A O   1 
HETATM 6256 O  O   . HOH D 3 .   ? 34.02626  2.05335   26.82232  1.000 40.58539  ?  1038 HOH A O   1 
HETATM 6257 O  O   . HOH D 3 .   ? 23.81936  -9.49185  20.86120  1.000 36.43853  ?  1039 HOH A O   1 
HETATM 6258 O  O   . HOH D 3 .   ? 6.80437   -0.65600  31.21824  1.000 46.47035  ?  1040 HOH A O   1 
HETATM 6259 O  O   . HOH D 3 .   ? 17.49839  2.25340   32.23163  1.000 33.89506  ?  1041 HOH A O   1 
HETATM 6260 O  O   . HOH D 3 .   ? -1.77607  16.33952  26.71046  1.000 48.92836  ?  1042 HOH A O   1 
HETATM 6261 O  O   . HOH D 3 .   ? 17.10147  -6.34589  33.72594  1.000 48.85258  ?  1043 HOH A O   1 
HETATM 6262 O  O   . HOH D 3 .   ? -9.02753  -7.47185  40.21798  1.000 40.34777  ?  1044 HOH A O   1 
HETATM 6263 O  O   . HOH D 3 .   ? 46.40429  4.15499   0.83296   1.000 51.83896  ?  1045 HOH A O   1 
HETATM 6264 O  O   . HOH D 3 .   ? 9.91977   7.98178   42.38679  1.000 35.93702  ?  1046 HOH A O   1 
HETATM 6265 O  O   . HOH D 3 .   ? 50.16529  6.97257   20.21479  1.000 51.58576  ?  1047 HOH A O   1 
HETATM 6266 O  O   . HOH D 3 .   ? -5.46874  18.61520  46.75657  1.000 42.65233  ?  1048 HOH A O   1 
HETATM 6267 O  O   . HOH D 3 .   ? -9.74904  -2.87367  57.50234  1.000 43.17698  ?  1049 HOH A O   1 
HETATM 6268 O  O   . HOH D 3 .   ? -14.14909 10.50841  47.12123  1.000 37.88919  ?  1050 HOH A O   1 
HETATM 6269 O  O   . HOH D 3 .   ? -11.16859 16.71578  32.49027  1.000 33.83691  ?  1051 HOH A O   1 
HETATM 6270 O  O   . HOH D 3 .   ? -2.39886  -5.26110  6.47448   1.000 44.81190  ?  1052 HOH A O   1 
HETATM 6271 O  O   . HOH D 3 .   ? 3.39800   -4.06562  63.18054  1.000 44.38314  ?  1053 HOH A O   1 
HETATM 6272 O  O   . HOH D 3 .   ? 0.08398   -10.94099 38.99405  1.000 58.46026  ?  1054 HOH A O   1 
HETATM 6273 O  O   . HOH D 3 .   ? 40.80284  4.19533   17.52545  1.000 47.25390  ?  1055 HOH A O   1 
HETATM 6274 O  O   . HOH D 3 .   ? 38.41852  6.10502   0.30371   1.000 51.72884  ?  1056 HOH A O   1 
HETATM 6275 O  O   . HOH D 3 .   ? 24.71363  -6.61077  39.04269  1.000 47.83583  ?  1057 HOH A O   1 
HETATM 6276 O  O   . HOH D 3 .   ? 26.05710  -22.68124 24.90765  1.000 61.59233  ?  1058 HOH A O   1 
HETATM 6277 O  O   . HOH D 3 .   ? -10.73238 2.19759   46.17073  1.000 35.55109  ?  1059 HOH A O   1 
HETATM 6278 O  O   . HOH D 3 .   ? 6.01256   -2.98633  19.24021  1.000 30.74575  ?  1060 HOH A O   1 
HETATM 6279 O  O   . HOH D 3 .   ? 34.79908  2.10196   5.68819   1.000 35.47352  ?  1061 HOH A O   1 
HETATM 6280 O  O   . HOH D 3 .   ? 21.53343  4.27288   52.43095  1.000 47.59738  ?  1062 HOH A O   1 
HETATM 6281 O  O   . HOH D 3 .   ? 46.35894  -13.90653 19.64285  1.000 41.11851  ?  1063 HOH A O   1 
HETATM 6282 O  O   . HOH D 3 .   ? 7.62057   -5.89084  -1.88831  1.000 46.08725  ?  1064 HOH A O   1 
HETATM 6283 O  O   . HOH D 3 .   ? -2.37524  -4.89035  10.02471  1.000 56.90024  ?  1065 HOH A O   1 
HETATM 6284 O  O   . HOH D 3 .   ? 26.16133  -20.33804 3.04934   1.000 32.52541  ?  1066 HOH A O   1 
HETATM 6285 O  O   . HOH D 3 .   ? -21.79051 6.55024   21.78381  1.000 42.31877  ?  1067 HOH A O   1 
HETATM 6286 O  O   . HOH D 3 .   ? 3.67804   -0.41927  2.99022   1.000 38.21863  ?  1068 HOH A O   1 
HETATM 6287 O  O   . HOH D 3 .   ? -10.29301 -18.99440 15.82563  1.000 55.07040  ?  1069 HOH A O   1 
HETATM 6288 O  O   . HOH D 3 .   ? 26.47342  -19.12408 -2.92140  1.000 44.41903  ?  1070 HOH A O   1 
HETATM 6289 O  O   . HOH D 3 .   ? 27.38115  -13.46730 -16.29409 1.000 50.24143  ?  1071 HOH A O   1 
HETATM 6290 O  O   . HOH D 3 .   ? 9.09585   8.98100   7.00640   1.000 32.49953  ?  1072 HOH A O   1 
HETATM 6291 O  O   . HOH D 3 .   ? 32.07110  7.47395   50.02433  1.000 66.89318  ?  1073 HOH A O   1 
HETATM 6292 O  O   . HOH D 3 .   ? 28.16197  1.23548   -16.56829 1.000 42.15916  ?  1074 HOH A O   1 
HETATM 6293 O  O   . HOH D 3 .   ? 16.12230  -30.18588 26.08433  1.000 55.65309  ?  1075 HOH A O   1 
HETATM 6294 O  O   . HOH D 3 .   ? -0.14113  1.22089   61.60675  1.000 37.81812  ?  1076 HOH A O   1 
HETATM 6295 O  O   . HOH D 3 .   ? 42.96036  -13.57416 -8.12926  1.000 58.89540  ?  1077 HOH A O   1 
HETATM 6296 O  O   . HOH D 3 .   ? -5.05392  16.99706  25.97051  1.000 48.07686  ?  1078 HOH A O   1 
HETATM 6297 O  O   . HOH D 3 .   ? -10.05289 2.50785   50.45399  1.000 37.80290  ?  1079 HOH A O   1 
HETATM 6298 O  O   . HOH D 3 .   ? 43.76799  1.34987   8.17630   1.000 40.31340  ?  1080 HOH A O   1 
HETATM 6299 O  O   . HOH D 3 .   ? 45.05664  1.39402   -9.66824  1.000 54.77226  ?  1081 HOH A O   1 
HETATM 6300 O  O   . HOH D 3 .   ? 13.37717  -6.19349  57.70703  1.000 47.35804  ?  1082 HOH A O   1 
HETATM 6301 O  O   . HOH D 3 .   ? 27.13931  -19.13502 -8.13177  1.000 45.60820  ?  1083 HOH A O   1 
HETATM 6302 O  O   . HOH D 3 .   ? 1.44163   12.93297  50.00955  1.000 38.45179  ?  1084 HOH A O   1 
HETATM 6303 O  O   . HOH D 3 .   ? 18.51421  -6.28925  5.68378   1.000 27.18831  ?  1085 HOH A O   1 
HETATM 6304 O  O   . HOH D 3 .   ? -13.50518 -7.06151  31.28793  1.000 48.77016  ?  1086 HOH A O   1 
HETATM 6305 O  O   . HOH D 3 .   ? 15.73262  7.60129   -5.67164  1.000 44.62536  ?  1087 HOH A O   1 
HETATM 6306 O  O   . HOH D 3 .   ? 37.73425  7.83265   39.75918  1.000 50.41538  ?  1088 HOH A O   1 
HETATM 6307 O  O   . HOH D 3 .   ? 41.95324  7.06140   -13.28378 1.000 51.78050  ?  1089 HOH A O   1 
HETATM 6308 O  O   . HOH D 3 .   ? 31.86625  -2.64527  -11.79425 1.000 40.22392  ?  1090 HOH A O   1 
HETATM 6309 O  O   . HOH D 3 .   ? 22.46604  -15.32272 9.59645   1.000 36.09114  ?  1091 HOH A O   1 
HETATM 6310 O  O   . HOH D 3 .   ? 11.06328  13.82862  36.81937  1.000 44.67061  ?  1092 HOH A O   1 
HETATM 6311 O  O   . HOH D 3 .   ? 33.62264  -17.72213 -7.53919  1.000 47.06236  ?  1093 HOH A O   1 
HETATM 6312 O  O   . HOH D 3 .   ? -15.92592 21.86945  31.81279  1.000 52.38263  ?  1094 HOH A O   1 
HETATM 6313 O  O   . HOH D 3 .   ? -3.69636  20.62697  33.45890  1.000 38.07510  ?  1095 HOH A O   1 
HETATM 6314 O  O   . HOH D 3 .   ? 14.41666  -2.09116  31.40318  1.000 44.95381  ?  1096 HOH A O   1 
HETATM 6315 O  O   . HOH D 3 .   ? -3.08511  -24.40076 27.84070  1.000 51.50801  ?  1097 HOH A O   1 
HETATM 6316 O  O   . HOH D 3 .   ? 24.10721  -16.33821 13.71836  1.000 34.35037  ?  1098 HOH A O   1 
HETATM 6317 O  O   . HOH D 3 .   ? 6.21025   10.44562  28.93004  1.000 38.33910  ?  1099 HOH A O   1 
HETATM 6318 O  O   . HOH D 3 .   ? 24.04937  -4.54801  15.91688  1.000 27.27082  ?  1100 HOH A O   1 
HETATM 6319 O  O   . HOH D 3 .   ? 2.05191   21.34180  40.06163  1.000 36.94322  ?  1101 HOH A O   1 
HETATM 6320 O  O   . HOH D 3 .   ? 50.70756  -13.57598 -5.09502  1.000 53.27028  ?  1102 HOH A O   1 
HETATM 6321 O  O   . HOH D 3 .   ? 15.47902  -7.45332  -0.31587  1.000 26.55651  ?  1103 HOH A O   1 
HETATM 6322 O  O   . HOH D 3 .   ? 35.54700  9.69463   28.09197  1.000 42.23582  ?  1104 HOH A O   1 
HETATM 6323 O  O   . HOH D 3 .   ? 31.02239  -20.86106 4.43797   1.000 43.36576  ?  1105 HOH A O   1 
HETATM 6324 O  O   . HOH D 3 .   ? 29.53388  2.28914   1.48422   1.000 24.68178  ?  1106 HOH A O   1 
HETATM 6325 O  O   . HOH D 3 .   ? 1.74072   -32.24254 39.95997  1.000 71.49202  ?  1107 HOH A O   1 
HETATM 6326 O  O   . HOH D 3 .   ? 7.43741   -2.71427  62.85601  1.000 57.30693  ?  1108 HOH A O   1 
HETATM 6327 O  O   . HOH D 3 .   ? 17.73789  3.02853   18.42853  1.000 46.07258  ?  1109 HOH A O   1 
HETATM 6328 O  O   . HOH D 3 .   ? 8.67638   13.09118  35.41572  1.000 41.19342  ?  1110 HOH A O   1 
HETATM 6329 O  O   . HOH D 3 .   ? 33.07315  -17.12548 18.15259  1.000 39.72289  ?  1111 HOH A O   1 
HETATM 6330 O  O   . HOH D 3 .   ? -16.31053 14.84285  15.75293  1.000 41.62472  ?  1112 HOH A O   1 
HETATM 6331 O  O   . HOH D 3 .   ? 16.67744  -0.32462  -2.59474  1.000 30.93886  ?  1113 HOH A O   1 
HETATM 6332 O  O   . HOH D 3 .   ? 13.50812  -8.67128  -1.60595  1.000 38.77312  ?  1114 HOH A O   1 
HETATM 6333 O  O   . HOH D 3 .   ? -3.28898  -16.35691 27.74975  1.000 42.84097  ?  1115 HOH A O   1 
HETATM 6334 O  O   . HOH D 3 .   ? 12.92690  -11.03378 -8.12713  1.000 45.11008  ?  1116 HOH A O   1 
HETATM 6335 O  O   . HOH D 3 .   ? 36.44132  2.21146   -10.92180 1.000 51.95855  ?  1117 HOH A O   1 
HETATM 6336 O  O   . HOH D 3 .   ? 45.82161  -3.82682  14.74669  1.000 33.90268  ?  1118 HOH A O   1 
HETATM 6337 O  O   . HOH D 3 .   ? -2.75758  23.62745  38.73510  1.000 36.57476  ?  1119 HOH A O   1 
HETATM 6338 O  O   . HOH D 3 .   ? -12.027   5.877     43.696    1.000 34.26443  ?  1120 HOH A O   1 
HETATM 6339 O  O   . HOH D 3 .   ? 12.71260  -20.02333 8.12073   1.000 42.12700  ?  1121 HOH A O   1 
HETATM 6340 O  O   . HOH D 3 .   ? 32.93761  -9.77987  18.32378  1.000 40.13793  ?  1122 HOH A O   1 
HETATM 6341 O  O   . HOH D 3 .   ? 41.84389  5.33630   -1.80130  1.000 35.01684  ?  1123 HOH A O   1 
HETATM 6342 O  O   . HOH D 3 .   ? 52.49929  -2.00419  -1.63949  1.000 46.96522  ?  1124 HOH A O   1 
HETATM 6343 O  O   . HOH D 3 .   ? 23.22036  7.24042   11.41349  1.000 53.07999  ?  1125 HOH A O   1 
HETATM 6344 O  O   . HOH D 3 .   ? 17.48902  -3.59111  5.99810   1.000 21.54586  ?  1126 HOH A O   1 
HETATM 6345 O  O   . HOH D 3 .   ? 40.13131  -3.39672  0.83076   1.000 33.83605  ?  1127 HOH A O   1 
HETATM 6346 O  O   . HOH D 3 .   ? 31.19857  3.74744   2.94172   1.000 31.73534  ?  1128 HOH A O   1 
HETATM 6347 O  O   . HOH D 3 .   ? 49.78673  -15.78446 4.87157   1.000 65.14915  ?  1129 HOH A O   1 
HETATM 6348 O  O   . HOH D 3 .   ? 11.30984  -16.12377 3.11322   1.000 38.96390  ?  1130 HOH A O   1 
HETATM 6349 O  O   . HOH D 3 .   ? 9.69392   -4.42907  39.96986  1.000 36.52132  ?  1131 HOH A O   1 
HETATM 6350 O  O   . HOH D 3 .   ? -14.11036 -3.90872  31.54306  1.000 43.28012  ?  1132 HOH A O   1 
HETATM 6351 O  O   . HOH D 3 .   ? -3.04327  4.29482   18.22962  1.000 40.19863  ?  1133 HOH A O   1 
HETATM 6352 O  O   . HOH D 3 .   ? -7.14168  13.49699  50.94279  1.000 51.84753  ?  1134 HOH A O   1 
HETATM 6353 O  O   . HOH D 3 .   ? -0.36078  2.10678   56.38901  1.000 32.77663  ?  1135 HOH A O   1 
HETATM 6354 O  O   . HOH D 3 .   ? 14.39291  -24.04717 15.43895  1.000 41.89695  ?  1136 HOH A O   1 
HETATM 6355 O  O   . HOH D 3 .   ? 17.90895  7.14056   -3.82452  1.000 53.20459  ?  1137 HOH A O   1 
HETATM 6356 O  O   . HOH D 3 .   ? 22.04895  0.26654   -21.17761 1.000 53.76802  ?  1138 HOH A O   1 
HETATM 6357 O  O   . HOH D 3 .   ? 23.01175  -19.28952 7.96117   1.000 46.30397  ?  1139 HOH A O   1 
HETATM 6358 O  O   . HOH D 3 .   ? 19.34479  -17.23720 8.42626   1.000 37.11996  ?  1140 HOH A O   1 
HETATM 6359 O  O   . HOH D 3 .   ? 36.63948  13.12174  -7.65489  1.000 43.58569  ?  1141 HOH A O   1 
HETATM 6360 O  O   . HOH D 3 .   ? 32.80816  5.15644   44.89479  1.000 45.80237  ?  1142 HOH A O   1 
HETATM 6361 O  O   . HOH D 3 .   ? 41.83856  15.30196  -5.34096  1.000 49.21098  ?  1143 HOH A O   1 
HETATM 6362 O  O   . HOH D 3 .   ? 28.11915  10.68936  7.57640   1.000 45.56556  ?  1144 HOH A O   1 
HETATM 6363 O  O   . HOH D 3 .   ? -9.34688  16.18403  17.06432  1.000 40.01846  ?  1145 HOH A O   1 
HETATM 6364 O  O   . HOH D 3 .   ? -12.88928 13.78025  33.42901  1.000 40.36264  ?  1146 HOH A O   1 
HETATM 6365 O  O   . HOH D 3 .   ? 2.52462   20.21525  53.55488  1.000 60.01630  ?  1147 HOH A O   1 
HETATM 6366 O  O   . HOH D 3 .   ? 34.06237  -20.73977 -2.42808  1.000 49.85880  ?  1148 HOH A O   1 
HETATM 6367 O  O   . HOH D 3 .   ? -0.44080  -14.12971 6.97032   1.000 42.88689  ?  1149 HOH A O   1 
HETATM 6368 O  O   . HOH D 3 .   ? 1.94238   11.50480  54.31347  1.000 41.39565  ?  1150 HOH A O   1 
HETATM 6369 O  O   . HOH D 3 .   ? -8.96099  -2.48251  29.33809  1.000 36.51439  ?  1151 HOH A O   1 
HETATM 6370 O  O   . HOH D 3 .   ? -0.96577  -5.47151  41.94920  1.000 37.94900  ?  1152 HOH A O   1 
HETATM 6371 O  O   . HOH D 3 .   ? 26.02036  -14.33853 14.91853  1.000 28.46360  ?  1153 HOH A O   1 
HETATM 6372 O  O   . HOH D 3 .   ? 14.52445  18.88072  39.81763  1.000 61.80026  ?  1154 HOH A O   1 
HETATM 6373 O  O   . HOH D 3 .   ? 4.64948   -12.83610 3.23403   1.000 36.58879  ?  1155 HOH A O   1 
HETATM 6374 O  O   . HOH D 3 .   ? 12.07851  16.62993  30.53285  1.000 46.46307  ?  1156 HOH A O   1 
HETATM 6375 O  O   . HOH D 3 .   ? 0.65544   19.98508  47.43010  1.000 42.43274  ?  1157 HOH A O   1 
HETATM 6376 O  O   . HOH D 3 .   ? 23.00427  -18.17211 -1.54411  1.000 40.65317  ?  1158 HOH A O   1 
HETATM 6377 O  O   . HOH D 3 .   ? -0.74946  -24.13290 6.74493   1.000 54.56861  ?  1159 HOH A O   1 
HETATM 6378 O  O   . HOH D 3 .   ? 21.05394  -17.33720 6.50313   1.000 36.33351  ?  1160 HOH A O   1 
HETATM 6379 O  O   . HOH D 3 .   ? 29.48754  14.97247  -2.08844  1.000 45.89824  ?  1161 HOH A O   1 
HETATM 6380 O  O   . HOH D 3 .   ? -11.67735 11.55090  10.91493  1.000 48.44670  ?  1162 HOH A O   1 
HETATM 6381 O  O   . HOH D 3 .   ? -18.56639 1.43337   43.99455  1.000 36.22158  ?  1163 HOH A O   1 
HETATM 6382 O  O   . HOH D 3 .   ? 41.54114  -15.89177 11.80117  1.000 34.14272  ?  1164 HOH A O   1 
HETATM 6383 O  O   . HOH D 3 .   ? 19.32727  -15.64143 10.42801  1.000 32.28280  ?  1165 HOH A O   1 
HETATM 6384 O  O   . HOH D 3 .   ? -0.91525  14.40683  30.39029  1.000 32.29177  ?  1166 HOH A O   1 
HETATM 6385 O  O   . HOH D 3 .   ? 42.39415  5.53473   16.69526  1.000 42.94727  ?  1167 HOH A O   1 
HETATM 6386 O  O   . HOH D 3 .   ? 40.00568  -0.53636  24.57613  1.000 44.96618  ?  1168 HOH A O   1 
HETATM 6387 O  O   . HOH D 3 .   ? 44.04212  -4.28333  18.57243  1.000 41.88446  ?  1169 HOH A O   1 
HETATM 6388 O  O   . HOH D 3 .   ? 27.75472  -19.98349 13.19281  1.000 46.57611  ?  1170 HOH A O   1 
HETATM 6389 O  O   . HOH D 3 .   ? -2.17738  -10.14661 36.11761  1.000 53.15265  ?  1171 HOH A O   1 
HETATM 6390 O  O   . HOH D 3 .   ? 20.24789  3.31396   5.38391   1.000 29.94002  ?  1172 HOH A O   1 
HETATM 6391 O  O   . HOH D 3 .   ? -8.43514  -8.83087  49.38288  1.000 48.00289  ?  1173 HOH A O   1 
HETATM 6392 O  O   . HOH D 3 .   ? 22.31792  -4.16430  38.09290  1.000 35.15378  ?  1174 HOH A O   1 
HETATM 6393 O  O   . HOH D 3 .   ? -19.16290 10.07548  23.26327  1.000 42.57409  ?  1175 HOH A O   1 
HETATM 6394 O  O   . HOH D 3 .   ? 1.69231   -13.10682 29.81986  1.000 32.37151  ?  1176 HOH A O   1 
HETATM 6395 O  O   . HOH D 3 .   ? 7.67635   15.81320  19.90473  1.000 57.47643  ?  1177 HOH A O   1 
HETATM 6396 O  O   . HOH D 3 .   ? -2.19166  8.69412   22.44270  1.000 36.94416  ?  1178 HOH A O   1 
HETATM 6397 O  O   . HOH D 3 .   ? 7.97062   8.73528   30.48302  1.000 32.30180  ?  1179 HOH A O   1 
HETATM 6398 O  O   . HOH D 3 .   ? 24.48050  16.93090  2.36278   1.000 51.48832  ?  1180 HOH A O   1 
HETATM 6399 O  O   . HOH D 3 .   ? -0.02282  8.53934   26.00058  1.000 47.37072  ?  1181 HOH A O   1 
HETATM 6400 O  O   . HOH D 3 .   ? 7.19747   -6.14481  46.12473  1.000 44.32685  ?  1182 HOH A O   1 
HETATM 6401 O  O   . HOH D 3 .   ? -12.62440 -2.15496  9.96183   1.000 41.80549  ?  1183 HOH A O   1 
HETATM 6402 O  O   . HOH D 3 .   ? 32.46685  6.34158   2.83142   1.000 34.26166  ?  1184 HOH A O   1 
HETATM 6403 O  O   . HOH D 3 .   ? 3.20673   2.47184   60.17222  1.000 42.09592  ?  1185 HOH A O   1 
HETATM 6404 O  O   . HOH D 3 .   ? 50.36203  -2.44126  -8.95638  1.000 47.94223  ?  1186 HOH A O   1 
HETATM 6405 O  O   . HOH D 3 .   ? -1.36463  2.54351   13.30400  1.000 44.42213  ?  1187 HOH A O   1 
HETATM 6406 O  O   . HOH D 3 .   ? 6.83035   5.69567   49.86153  1.000 37.11122  ?  1188 HOH A O   1 
HETATM 6407 O  O   . HOH D 3 .   ? -2.30766  5.88685   21.56138  1.000 38.66437  ?  1189 HOH A O   1 
HETATM 6408 O  O   . HOH D 3 .   ? 20.31401  -9.40700  28.93320  1.000 43.89511  ?  1190 HOH A O   1 
HETATM 6409 O  O   . HOH D 3 .   ? 10.56428  -11.45852 43.02332  1.000 44.95597  ?  1191 HOH A O   1 
HETATM 6410 O  O   . HOH D 3 .   ? 19.68523  -18.83254 4.60324   1.000 40.85902  ?  1192 HOH A O   1 
HETATM 6411 O  O   . HOH D 3 .   ? 31.00408  -1.37237  15.37277  1.000 40.43053  ?  1193 HOH A O   1 
HETATM 6412 O  O   . HOH D 3 .   ? -9.95295  4.70494   45.04582  1.000 31.86077  ?  1194 HOH A O   1 
HETATM 6413 O  O   . HOH D 3 .   ? 22.11456  6.25343   -11.04650 1.000 39.01106  ?  1195 HOH A O   1 
HETATM 6414 O  O   . HOH D 3 .   ? 22.98568  -1.65065  18.43800  1.000 37.98936  ?  1196 HOH A O   1 
HETATM 6415 O  O   . HOH D 3 .   ? -5.54156  19.69941  26.08607  1.000 49.19977  ?  1197 HOH A O   1 
HETATM 6416 O  O   . HOH D 3 .   ? 11.51533  4.21308   58.45614  1.000 46.57711  ?  1198 HOH A O   1 
HETATM 6417 O  O   . HOH D 3 .   ? 30.28972  2.50868   11.06395  1.000 36.81228  ?  1199 HOH A O   1 
HETATM 6418 O  O   . HOH D 3 .   ? 17.05858  9.78765   -3.32965  1.000 41.61626  ?  1200 HOH A O   1 
HETATM 6419 O  O   . HOH D 3 .   ? 22.55296  5.18886   -19.00386 1.000 50.94300  ?  1201 HOH A O   1 
HETATM 6420 O  O   . HOH D 3 .   ? 39.59129  7.05227   -1.96666  1.000 39.15313  ?  1202 HOH A O   1 
HETATM 6421 O  O   . HOH D 3 .   ? 8.65318   4.58417   55.72549  1.000 45.95369  ?  1203 HOH A O   1 
HETATM 6422 O  O   . HOH D 3 .   ? 48.95420  -13.80288 5.77473   1.000 45.40218  ?  1204 HOH A O   1 
HETATM 6423 O  O   . HOH D 3 .   ? -24.62390 6.00302   21.87146  1.000 49.37540  ?  1205 HOH A O   1 
HETATM 6424 O  O   . HOH D 3 .   ? 47.20964  2.80561   9.41850   1.000 42.81457  ?  1206 HOH A O   1 
HETATM 6425 O  O   . HOH D 3 .   ? 19.60188  7.15816   -13.11401 1.000 43.38930  ?  1207 HOH A O   1 
HETATM 6426 O  O   . HOH D 3 .   ? 44.22538  6.17206   -3.41625  1.000 45.15944  ?  1208 HOH A O   1 
HETATM 6427 O  O   . HOH D 3 .   ? -12.37607 -10.29865 30.20059  1.000 50.59818  ?  1209 HOH A O   1 
HETATM 6428 O  O   . HOH D 3 .   ? 44.12682  -2.26524  -11.29844 1.000 52.34238  ?  1210 HOH A O   1 
HETATM 6429 O  O   . HOH D 3 .   ? -5.62015  3.63059   51.27147  1.000 38.52442  ?  1211 HOH A O   1 
HETATM 6430 O  O   . HOH D 3 .   ? -11.44672 -0.52635  11.86694  1.000 47.74594  ?  1212 HOH A O   1 
HETATM 6431 O  O   . HOH D 3 .   ? -6.99066  -4.91677  43.06385  1.000 48.91197  ?  1213 HOH A O   1 
HETATM 6432 O  O   . HOH D 3 .   ? 34.72780  -14.98092 18.25885  1.000 29.10448  ?  1214 HOH A O   1 
HETATM 6433 O  O   . HOH D 3 .   ? 35.24963  -19.84916 12.07742  1.000 42.23424  ?  1215 HOH A O   1 
HETATM 6434 O  O   . HOH D 3 .   ? 3.57277   -10.16600 38.11205  1.000 57.85219  ?  1216 HOH A O   1 
HETATM 6435 O  O   . HOH D 3 .   ? 20.04180  -11.72735 33.67531  1.000 59.29237  ?  1217 HOH A O   1 
HETATM 6436 O  O   . HOH D 3 .   ? 13.89150  3.14216   45.00203  1.000 34.11244  ?  1218 HOH A O   1 
HETATM 6437 O  O   . HOH D 3 .   ? 35.13314  9.34965   42.80165  1.000 56.14693  ?  1219 HOH A O   1 
HETATM 6438 O  O   . HOH D 3 .   ? 36.67277  1.63327   12.40647  1.000 35.25781  ?  1220 HOH A O   1 
HETATM 6439 O  O   . HOH D 3 .   ? 15.44002  1.93346   22.52667  1.000 51.12037  ?  1221 HOH A O   1 
HETATM 6440 O  O   . HOH D 3 .   ? -19.85328 3.93234   22.35187  1.000 50.64245  ?  1222 HOH A O   1 
HETATM 6441 O  O   . HOH D 3 .   ? -9.43256  -4.35504  33.58665  1.000 34.77470  ?  1223 HOH A O   1 
HETATM 6442 O  O   . HOH D 3 .   ? 21.70997  -6.87235  28.77505  1.000 45.37221  ?  1224 HOH A O   1 
HETATM 6443 O  O   . HOH D 3 .   ? 39.53589  7.43377   -11.48379 1.000 47.31645  ?  1225 HOH A O   1 
HETATM 6444 O  O   . HOH D 3 .   ? 13.82371  13.24800  45.81803  1.000 47.41093  ?  1226 HOH A O   1 
HETATM 6445 O  O   . HOH D 3 .   ? 19.84152  5.63871   45.41987  1.000 43.21785  ?  1227 HOH A O   1 
HETATM 6446 O  O   . HOH D 3 .   ? 17.42766  12.49195  46.54273  1.000 57.61678  ?  1228 HOH A O   1 
HETATM 6447 O  O   . HOH D 3 .   ? 30.76767  13.53925  3.19378   1.000 42.71863  ?  1229 HOH A O   1 
HETATM 6448 O  O   . HOH D 3 .   ? 28.60589  -10.21468 27.40885  1.000 44.87294  ?  1230 HOH A O   1 
HETATM 6449 O  O   . HOH D 3 .   ? 42.58835  7.60543   -8.36772  1.000 46.31894  ?  1231 HOH A O   1 
HETATM 6450 O  O   . HOH D 3 .   ? 53.70411  3.61756   6.80580   1.000 42.49996  ?  1232 HOH A O   1 
HETATM 6451 O  O   . HOH D 3 .   ? 44.68537  7.51196   -6.74267  1.000 44.57351  ?  1233 HOH A O   1 
HETATM 6452 O  O   . HOH D 3 .   ? 35.11243  -21.47060 8.19560   1.000 44.58486  ?  1234 HOH A O   1 
HETATM 6453 O  O   . HOH D 3 .   ? 7.03935   -15.99309 0.58871   1.000 45.18560  ?  1235 HOH A O   1 
HETATM 6454 O  O   . HOH D 3 .   ? 5.29954   -6.35064  35.92797  1.000 45.22120  ?  1236 HOH A O   1 
HETATM 6455 O  O   . HOH D 3 .   ? 33.87367  10.91113  -0.38512  1.000 44.59090  ?  1237 HOH A O   1 
HETATM 6456 O  O   . HOH D 3 .   ? -17.90989 2.39848   30.68261  1.000 47.07016  ?  1238 HOH A O   1 
HETATM 6457 O  O   . HOH D 3 .   ? 23.61757  -17.89494 11.22567  1.000 43.02067  ?  1239 HOH A O   1 
HETATM 6458 O  O   . HOH D 3 .   ? 0.61510   -9.36052  33.54751  1.000 57.50505  ?  1240 HOH A O   1 
HETATM 6459 O  O   . HOH D 3 .   ? 8.58279   -16.08387 6.51530   1.000 51.89565  ?  1241 HOH A O   1 
HETATM 6460 O  O   . HOH D 3 .   ? 55.29479  -0.63173  21.12821  1.000 48.72157  ?  1242 HOH A O   1 
HETATM 6461 O  O   . HOH D 3 .   ? 0.13525   -13.50588 3.91716   1.000 55.28304  ?  1243 HOH A O   1 
HETATM 6462 O  O   . HOH D 3 .   ? 25.79782  -4.27985  -14.88824 1.000 45.84963  ?  1244 HOH A O   1 
HETATM 6463 O  O   . HOH D 3 .   ? 18.81068  -7.92400  36.71905  1.000 54.41413  ?  1245 HOH A O   1 
HETATM 6464 O  O   . HOH D 3 .   ? -11.11452 0.08010   49.81762  1.000 30.31158  ?  1246 HOH A O   1 
HETATM 6465 O  O   . HOH D 3 .   ? 51.20326  3.80780   23.07507  1.000 50.36099  ?  1247 HOH A O   1 
HETATM 6466 O  O   . HOH D 3 .   ? 0.71153   -10.56516 29.27139  1.000 35.53542  ?  1248 HOH A O   1 
HETATM 6467 O  O   . HOH D 3 .   ? 6.56725   15.93746  4.56250   1.000 55.01562  ?  1249 HOH A O   1 
HETATM 6468 O  O   . HOH D 3 .   ? 5.67873   -27.44461 16.47151  1.000 53.72092  ?  1250 HOH A O   1 
HETATM 6469 O  O   . HOH D 3 .   ? 7.24785   12.91492  16.43314  1.000 61.19877  ?  1251 HOH A O   1 
HETATM 6470 O  O   . HOH D 3 .   ? 13.39682  -14.70814 -3.00721  1.000 54.20081  ?  1252 HOH A O   1 
HETATM 6471 O  O   . HOH D 3 .   ? -3.18363  -8.80832  47.54007  1.000 51.89313  ?  1253 HOH A O   1 
HETATM 6472 O  O   . HOH D 3 .   ? -15.32829 -7.59365  38.97341  1.000 45.35217  ?  1254 HOH A O   1 
HETATM 6473 O  O   . HOH D 3 .   ? 49.72832  4.62843   0.97935   1.000 47.24031  ?  1255 HOH A O   1 
HETATM 6474 O  O   . HOH D 3 .   ? -15.50778 6.19329   36.48187  1.000 42.38900  ?  1256 HOH A O   1 
HETATM 6475 O  O   . HOH D 3 .   ? 49.75219  3.25230   -0.75868  1.000 42.92934  ?  1257 HOH A O   1 
HETATM 6476 O  O   . HOH D 3 .   ? 27.91515  11.20926  -12.98701 1.000 52.37373  ?  1258 HOH A O   1 
HETATM 6477 O  O   . HOH D 3 .   ? -6.62734  25.78632  39.60511  1.000 50.25053  ?  1259 HOH A O   1 
HETATM 6478 O  O   . HOH D 3 .   ? 51.71603  -13.48460 16.78574  1.000 38.76938  ?  1260 HOH A O   1 
HETATM 6479 O  O   . HOH D 3 .   ? 4.90186   -10.32876 3.08028   1.000 38.36087  ?  1261 HOH A O   1 
HETATM 6480 O  O   . HOH D 3 .   ? 33.01826  -7.36571  -16.43583 1.000 48.67269  ?  1262 HOH A O   1 
HETATM 6481 O  O   . HOH D 3 .   ? 25.61181  -2.46275  19.46712  1.000 42.13886  ?  1263 HOH A O   1 
HETATM 6482 O  O   . HOH D 3 .   ? 12.51549  -21.32197 34.95054  1.000 54.09657  ?  1264 HOH A O   1 
HETATM 6483 O  O   . HOH D 3 .   ? -18.23387 7.11509   28.73174  1.000 47.42447  ?  1265 HOH A O   1 
HETATM 6484 O  O   . HOH D 3 .   ? 43.61666  0.61760   22.16531  1.000 46.78306  ?  1266 HOH A O   1 
HETATM 6485 O  O   . HOH D 3 .   ? 19.43969  -15.70094 38.17474  1.000 68.26200  ?  1267 HOH A O   1 
HETATM 6486 O  O   . HOH D 3 .   ? 17.53765  -11.40755 35.78956  1.000 55.19494  ?  1268 HOH A O   1 
HETATM 6487 O  O   . HOH D 3 .   ? 5.25791   5.75382   53.60967  1.000 49.48770  ?  1269 HOH A O   1 
HETATM 6488 O  O   . HOH D 3 .   ? 35.97350  -14.91537 21.09258  1.000 45.65684  ?  1270 HOH A O   1 
HETATM 6489 O  O   . HOH D 3 .   ? -0.63557  19.38052  51.52393  1.000 47.80683  ?  1271 HOH A O   1 
HETATM 6490 O  O   . HOH D 3 .   ? 7.78668   16.52197  29.32714  1.000 43.55809  ?  1272 HOH A O   1 
HETATM 6491 O  O   . HOH D 3 .   ? 29.00720  -6.43579  39.06649  1.000 44.67162  ?  1273 HOH A O   1 
HETATM 6492 O  O   . HOH D 3 .   ? -4.31877  -23.75814 9.03961   1.000 52.80325  ?  1274 HOH A O   1 
HETATM 6493 O  O   . HOH D 3 .   ? 42.30667  6.11547   6.43214   1.000 50.62618  ?  1275 HOH A O   1 
HETATM 6494 O  O   . HOH D 3 .   ? -12.30447 6.61315   6.30391   1.000 44.55614  ?  1276 HOH A O   1 
HETATM 6495 O  O   . HOH D 3 .   ? -1.47941  -10.00090 30.29479  1.000 42.13085  ?  1277 HOH A O   1 
HETATM 6496 O  O   . HOH D 3 .   ? 26.09536  -8.40888  32.03143  1.000 47.14427  ?  1278 HOH A O   1 
HETATM 6497 O  O   . HOH D 3 .   ? 37.27239  -11.23210 -13.37781 1.000 53.14873  ?  1279 HOH A O   1 
HETATM 6498 O  O   . HOH D 3 .   ? -18.96755 6.04002   36.26559  1.000 54.03954  ?  1280 HOH A O   1 
HETATM 6499 O  O   . HOH D 3 .   ? -1.24562  -3.34339  27.50661  1.000 53.68914  ?  1281 HOH A O   1 
HETATM 6500 O  O   . HOH D 3 .   ? -14.72070 10.50195  9.77094   1.000 58.25151  ?  1282 HOH A O   1 
HETATM 6501 O  O   . HOH D 3 .   ? 17.28911  -19.70798 5.21406   1.000 44.40988  ?  1283 HOH A O   1 
HETATM 6502 O  O   . HOH D 3 .   ? -1.42075  -7.71590  53.15522  1.000 42.71392  ?  1284 HOH A O   1 
HETATM 6503 O  O   . HOH D 3 .   ? 8.05088   -12.33051 54.62005  1.000 43.79811  ?  1285 HOH A O   1 
HETATM 6504 O  O   . HOH D 3 .   ? 23.97214  7.39974   -17.96002 1.000 39.38951  ?  1286 HOH A O   1 
HETATM 6505 O  O   . HOH D 3 .   ? 10.25522  -8.98527  40.88659  1.000 50.86713  ?  1287 HOH A O   1 
HETATM 6506 O  O   . HOH D 3 .   ? 36.55477  -22.14733 10.42876  1.000 51.74230  ?  1288 HOH A O   1 
HETATM 6507 O  O   . HOH D 3 .   ? 5.12662   18.90816  28.97373  1.000 45.59028  ?  1289 HOH A O   1 
HETATM 6508 O  O   . HOH D 3 .   ? 24.878    12.182    -12.003   1.000 46.81217  ?  1290 HOH A O   1 
HETATM 6509 O  O   . HOH D 3 .   ? 41.95477  -14.25436 -10.38266 1.000 55.46628  ?  1291 HOH A O   1 
HETATM 6510 O  O   . HOH D 3 .   ? -9.68066  23.79296  36.19744  1.000 37.40835  ?  1292 HOH A O   1 
HETATM 6511 O  O   . HOH D 3 .   ? 41.87714  -9.27342  35.06451  1.000 53.12890  ?  1293 HOH A O   1 
HETATM 6512 O  O   . HOH D 3 .   ? 14.61467  5.89834   45.27376  1.000 41.41500  ?  1294 HOH A O   1 
HETATM 6513 O  O   . HOH D 3 .   ? 4.06851   9.11834   53.04467  1.000 48.34973  ?  1295 HOH A O   1 
HETATM 6514 O  O   . HOH D 3 .   ? -12.59542 21.12944  37.76055  1.000 45.87402  ?  1296 HOH A O   1 
HETATM 6515 O  O   . HOH D 3 .   ? -7.92172  -7.11335  42.92800  1.000 51.01504  ?  1297 HOH A O   1 
HETATM 6516 O  O   . HOH D 3 .   ? 13.62336  0.44922   29.66540  1.000 47.48030  ?  1298 HOH A O   1 
HETATM 6517 O  O   . HOH D 3 .   ? 20.28955  -5.28973  31.01622  1.000 45.79122  ?  1299 HOH A O   1 
HETATM 6518 O  O   . HOH D 3 .   ? 12.78877  14.45732  43.79544  1.000 50.72903  ?  1300 HOH A O   1 
HETATM 6519 O  O   . HOH D 3 .   ? 26.18654  -7.04168  41.68241  1.000 55.78180  ?  1301 HOH A O   1 
HETATM 6520 O  O   . HOH D 3 .   ? 11.21754  6.67421   44.98597  1.000 44.94728  ?  1302 HOH A O   1 
HETATM 6521 O  O   . HOH D 3 .   ? 29.70078  2.12724   13.95520  1.000 39.21536  ?  1303 HOH A O   1 
HETATM 6522 O  O   . HOH D 3 .   ? 4.45983   10.51528  50.44683  1.000 37.22137  ?  1304 HOH A O   1 
HETATM 6523 O  O   . HOH D 3 .   ? -1.49308  6.47192   18.96393  1.000 43.76485  ?  1305 HOH A O   1 
HETATM 6524 O  O   . HOH D 3 .   ? 38.90796  -5.02870  10.07857  1.000 20.68816  ?  1306 HOH A O   1 
HETATM 6525 O  O   . HOH D 3 .   ? -8.67343  -21.36272 16.94798  1.000 55.36074  ?  1307 HOH A O   1 
HETATM 6526 O  O   . HOH D 3 .   ? 3.62334   13.09592  50.71200  1.000 43.62329  ?  1308 HOH A O   1 
HETATM 6527 O  O   . HOH D 3 .   ? 29.72752  -17.12327 16.82636  1.000 42.60796  ?  1309 HOH A O   1 
HETATM 6528 O  O   . HOH D 3 .   ? 43.76148  -4.21596  20.59495  1.000 40.73789  ?  1310 HOH A O   1 
HETATM 6529 O  O   . HOH D 3 .   ? 38.385    15.488    -9.206    1.000 59.37491  ?  1311 HOH A O   1 
HETATM 6530 O  O   . HOH D 3 .   ? 22.52621  -20.38297 -3.44139  1.000 55.66047  ?  1312 HOH A O   1 
HETATM 6531 O  O   . HOH D 3 .   ? -4.53245  -6.85031  10.59840  1.000 45.58622  ?  1313 HOH A O   1 
HETATM 6532 O  O   . HOH D 3 .   ? 35.34837  -19.29259 9.71872   1.000 49.73990  ?  1314 HOH A O   1 
HETATM 6533 O  O   . HOH D 3 .   ? 8.17701   12.93033  27.83238  1.000 39.96230  ?  1315 HOH A O   1 
HETATM 6534 O  O   . HOH D 3 .   ? 10.02342  14.01496  26.88644  1.000 53.70494  ?  1316 HOH A O   1 
HETATM 6535 O  O   . HOH D 3 .   ? 15.70793  -6.08806  56.81832  1.000 54.15985  ?  1317 HOH A O   1 
HETATM 6536 O  O   . HOH D 3 .   ? 2.25750   -8.42521  54.94609  1.000 50.04624  ?  1318 HOH A O   1 
HETATM 6537 O  O   . HOH D 3 .   ? 1.90858   1.57917   3.35718   1.000 49.88447  ?  1319 HOH A O   1 
HETATM 6538 O  O   . HOH D 3 .   ? 7.99467   -29.26756 15.57779  1.000 61.75266  ?  1320 HOH A O   1 
HETATM 6539 O  O   . HOH D 3 .   ? 20.97176  8.04376   43.67786  1.000 47.83312  ?  1321 HOH A O   1 
HETATM 6540 O  O   . HOH D 3 .   ? 8.17085   14.80858  24.91226  1.000 49.04195  ?  1322 HOH A O   1 
HETATM 6541 O  O   . HOH D 3 .   ? 3.42463   6.29276   55.69812  1.000 44.53047  ?  1323 HOH A O   1 
HETATM 6542 O  O   . HOH D 3 .   ? 30.379    13.433    -6.231    1.000 42.91551  ?  1324 HOH A O   1 
HETATM 6543 O  O   . HOH D 3 .   ? -11.05910 -3.29532  31.23805  1.000 41.11329  ?  1325 HOH A O   1 
HETATM 6544 O  O   . HOH D 3 .   ? -21.21376 -3.62404  23.47684  1.000 54.58247  ?  1326 HOH A O   1 
HETATM 6545 O  O   . HOH D 3 .   ? 1.31658   -7.95285  52.99018  1.000 44.41589  ?  1327 HOH A O   1 
HETATM 6546 O  O   . HOH D 3 .   ? 17.59300  -7.15617  57.55709  1.000 56.59737  ?  1328 HOH A O   1 
HETATM 6547 O  O   . HOH D 3 .   ? -6.84561  17.81665  48.30757  1.000 56.35301  ?  1329 HOH A O   1 
HETATM 6548 O  O   . HOH D 3 .   ? 19.07490  8.97339   44.26356  1.000 50.04985  ?  1330 HOH A O   1 
HETATM 6549 O  O   . HOH D 3 .   ? 20.89069  6.26414   47.99140  1.000 45.50084  ?  1331 HOH A O   1 
HETATM 6550 O  O   . HOH D 3 .   ? -2.88500  -25.65190 8.98893   1.000 52.95856  ?  1332 HOH A O   1 
HETATM 6551 O  O   . HOH D 3 .   ? 33.45928  12.95400  -0.44546  1.000 58.07043  ?  1333 HOH A O   1 
HETATM 6552 O  O   . HOH D 3 .   ? 5.49042   -15.33069 1.44653   1.000 44.12782  ?  1334 HOH A O   1 
HETATM 6553 O  O   . HOH D 3 .   ? 0.78788   4.51039   56.64737  1.000 38.92864  ?  1335 HOH A O   1 
HETATM 6554 O  O   . HOH D 3 .   ? 29.10654  -18.10753 14.88551  1.000 42.60620  ?  1336 HOH A O   1 
HETATM 6555 O  O   . HOH D 3 .   ? 14.54465  -22.69255 34.56130  1.000 60.89468  ?  1337 HOH A O   1 
HETATM 6556 O  O   . HOH D 3 .   ? 7.48323   16.83570  25.50362  1.000 49.16856  ?  1338 HOH A O   1 
HETATM 6557 O  O   . HOH D 3 .   ? 28.28318  -5.31182  41.49708  1.000 48.73452  ?  1339 HOH A O   1 
HETATM 6558 O  O   . HOH D 3 .   ? 17.75412  7.18503   45.66027  1.000 48.77170  ?  1340 HOH A O   1 
HETATM 6559 O  O   . HOH D 3 .   ? 30.69497  1.15148   -15.11555 1.000 46.76903  ?  1341 HOH A O   1 
HETATM 6560 O  O   . HOH D 3 .   ? -11.65435 23.10179  36.30891  1.000 42.58282  ?  1342 HOH A O   1 
HETATM 6561 O  O   . HOH D 3 .   ? 23.60675  5.10613   49.64183  1.000 48.64696  ?  1343 HOH A O   1 
HETATM 6562 O  O   . HOH D 3 .   ? 7.81862   17.37090  43.86655  1.000 42.93525  ?  1344 HOH A O   1 
HETATM 6563 O  O   . HOH D 3 .   ? 48.47522  -2.02935  -10.88385 1.000 52.55933  ?  1345 HOH A O   1 
HETATM 6564 O  O   . HOH D 3 .   ? -7.06540  25.43826  42.59773  1.000 49.65787  ?  1346 HOH A O   1 
HETATM 6565 O  O   . HOH D 3 .   ? 42.72763  8.24426   17.97511  1.000 55.37063  ?  1347 HOH A O   1 
HETATM 6566 O  O   . HOH D 3 .   ? -3.45901  -9.73926  54.05026  1.000 51.59925  ?  1348 HOH A O   1 
HETATM 6567 O  O   . HOH D 3 .   ? 4.75826   22.70859  39.43607  1.000 55.25772  ?  1349 HOH A O   1 
HETATM 6568 O  O   . HOH D 3 .   ? 10.08818  15.78001  44.92712  1.000 54.40959  ?  1350 HOH A O   1 
HETATM 6569 O  O   . HOH D 3 .   ? 8.47019   19.75309  44.63259  1.000 58.02293  ?  1351 HOH A O   1 
# 
