data_8ZMX
# 
_entry.id   8ZMX 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZMX         pdb_00008zmx 10.2210/pdb8zmx/pdb 
WWPDB D_1300046211 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-13 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZMX 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              zjzhang@ecust.edu.cn 
_pdbx_contact_author.name_first         Jun 
_pdbx_contact_author.name_last          Zhang 
_pdbx_contact_author.name_mi            Z. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9836-0204 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Geng, Q.'    1 0000-0003-2842-8263 
'Wei, Y.'     2 0009-0001-9035-4552 
'Zhang, Z.J.' 3 0000-0001-9836-0204 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Catalysis' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2155-5435 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            14 
_citation.language                  ? 
_citation.page_first                11447 
_citation.page_last                 11456 
_citation.title                     
'Hierarchical Engineering of meso-Diaminopimelate Dehydrogenase for Efficient Synthesis of Bulky d-Amino Acids' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acscatal.4c03164 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wei, Y.'     1 ? 
primary 'Geng, Q.'    2 ? 
primary 'Liu, H.P.'   3 ? 
primary 'Wang, Y.Q.'  4 ? 
primary 'Zhang, G.F.' 5 ? 
primary 'Qian, X.L.'  6 ? 
primary 'Yu, H.L.'    7 ? 
primary 'Xu, J.H.'    8 ? 
primary 'Zhang, Z.J.' 9 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Meso-diaminopimelate D-dehydrogenase'             34705.805 3  1.4.1.16 W129T,D134C,F154V,S177A,H235I ? ? 
2 non-polymer syn 'NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE' 743.405   3  ?        ?                             ? ? 
3 water       nat water                                              18.015    26 ?        ?                             ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'DAPDH,Meso-DAP dehydrogenase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MHHHHHHSEIRTERPIRVAIIGYGNIGQYALQAVEEAPDMELAGVVRRQSSLEKPLPRELHGVSVVSDVSALGQVDVAVL
CTPTRETPAIAKELLARGIHTIDSFDIHQEIVQVRHELDEVARAHQAVAILAAGTDPGTCSMIRSILEFMAPYGITYTNV
GPGMSMGHSVAVKAIEGVKDALALTIPIGTGLHRRMVYVELEEGADFATVKERILQDPYFVHDETHVLQVDDVKQLIDRG
IGVRMERKGVSGQTQNQLFTYEMRINNPALTSQVMIASARAAMRQKPGAYTMIEIPIIDFLYGDRDELIRRLV
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MHHHHHHSEIRTERPIRVAIIGYGNIGQYALQAVEEAPDMELAGVVRRQSSLEKPLPRELHGVSVVSDVSALGQVDVAVL
CTPTRETPAIAKELLARGIHTIDSFDIHQEIVQVRHELDEVARAHQAVAILAAGTDPGTCSMIRSILEFMAPYGITYTNV
GPGMSMGHSVAVKAIEGVKDALALTIPIGTGLHRRMVYVELEEGADFATVKERILQDPYFVHDETHVLQVDDVKQLIDRG
IGVRMERKGVSGQTQNQLFTYEMRINNPALTSQVMIASARAAMRQKPGAYTMIEIPIIDFLYGDRDELIRRLV
;
_entity_poly.pdbx_strand_id                 A,B,C 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE' NAP 
3 water                                              HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   SER n 
1 9   GLU n 
1 10  ILE n 
1 11  ARG n 
1 12  THR n 
1 13  GLU n 
1 14  ARG n 
1 15  PRO n 
1 16  ILE n 
1 17  ARG n 
1 18  VAL n 
1 19  ALA n 
1 20  ILE n 
1 21  ILE n 
1 22  GLY n 
1 23  TYR n 
1 24  GLY n 
1 25  ASN n 
1 26  ILE n 
1 27  GLY n 
1 28  GLN n 
1 29  TYR n 
1 30  ALA n 
1 31  LEU n 
1 32  GLN n 
1 33  ALA n 
1 34  VAL n 
1 35  GLU n 
1 36  GLU n 
1 37  ALA n 
1 38  PRO n 
1 39  ASP n 
1 40  MET n 
1 41  GLU n 
1 42  LEU n 
1 43  ALA n 
1 44  GLY n 
1 45  VAL n 
1 46  VAL n 
1 47  ARG n 
1 48  ARG n 
1 49  GLN n 
1 50  SER n 
1 51  SER n 
1 52  LEU n 
1 53  GLU n 
1 54  LYS n 
1 55  PRO n 
1 56  LEU n 
1 57  PRO n 
1 58  ARG n 
1 59  GLU n 
1 60  LEU n 
1 61  HIS n 
1 62  GLY n 
1 63  VAL n 
1 64  SER n 
1 65  VAL n 
1 66  VAL n 
1 67  SER n 
1 68  ASP n 
1 69  VAL n 
1 70  SER n 
1 71  ALA n 
1 72  LEU n 
1 73  GLY n 
1 74  GLN n 
1 75  VAL n 
1 76  ASP n 
1 77  VAL n 
1 78  ALA n 
1 79  VAL n 
1 80  LEU n 
1 81  CYS n 
1 82  THR n 
1 83  PRO n 
1 84  THR n 
1 85  ARG n 
1 86  GLU n 
1 87  THR n 
1 88  PRO n 
1 89  ALA n 
1 90  ILE n 
1 91  ALA n 
1 92  LYS n 
1 93  GLU n 
1 94  LEU n 
1 95  LEU n 
1 96  ALA n 
1 97  ARG n 
1 98  GLY n 
1 99  ILE n 
1 100 HIS n 
1 101 THR n 
1 102 ILE n 
1 103 ASP n 
1 104 SER n 
1 105 PHE n 
1 106 ASP n 
1 107 ILE n 
1 108 HIS n 
1 109 GLN n 
1 110 GLU n 
1 111 ILE n 
1 112 VAL n 
1 113 GLN n 
1 114 VAL n 
1 115 ARG n 
1 116 HIS n 
1 117 GLU n 
1 118 LEU n 
1 119 ASP n 
1 120 GLU n 
1 121 VAL n 
1 122 ALA n 
1 123 ARG n 
1 124 ALA n 
1 125 HIS n 
1 126 GLN n 
1 127 ALA n 
1 128 VAL n 
1 129 ALA n 
1 130 ILE n 
1 131 LEU n 
1 132 ALA n 
1 133 ALA n 
1 134 GLY n 
1 135 THR n 
1 136 ASP n 
1 137 PRO n 
1 138 GLY n 
1 139 THR n 
1 140 CYS n 
1 141 SER n 
1 142 MET n 
1 143 ILE n 
1 144 ARG n 
1 145 SER n 
1 146 ILE n 
1 147 LEU n 
1 148 GLU n 
1 149 PHE n 
1 150 MET n 
1 151 ALA n 
1 152 PRO n 
1 153 TYR n 
1 154 GLY n 
1 155 ILE n 
1 156 THR n 
1 157 TYR n 
1 158 THR n 
1 159 ASN n 
1 160 VAL n 
1 161 GLY n 
1 162 PRO n 
1 163 GLY n 
1 164 MET n 
1 165 SER n 
1 166 MET n 
1 167 GLY n 
1 168 HIS n 
1 169 SER n 
1 170 VAL n 
1 171 ALA n 
1 172 VAL n 
1 173 LYS n 
1 174 ALA n 
1 175 ILE n 
1 176 GLU n 
1 177 GLY n 
1 178 VAL n 
1 179 LYS n 
1 180 ASP n 
1 181 ALA n 
1 182 LEU n 
1 183 ALA n 
1 184 LEU n 
1 185 THR n 
1 186 ILE n 
1 187 PRO n 
1 188 ILE n 
1 189 GLY n 
1 190 THR n 
1 191 GLY n 
1 192 LEU n 
1 193 HIS n 
1 194 ARG n 
1 195 ARG n 
1 196 MET n 
1 197 VAL n 
1 198 TYR n 
1 199 VAL n 
1 200 GLU n 
1 201 LEU n 
1 202 GLU n 
1 203 GLU n 
1 204 GLY n 
1 205 ALA n 
1 206 ASP n 
1 207 PHE n 
1 208 ALA n 
1 209 THR n 
1 210 VAL n 
1 211 LYS n 
1 212 GLU n 
1 213 ARG n 
1 214 ILE n 
1 215 LEU n 
1 216 GLN n 
1 217 ASP n 
1 218 PRO n 
1 219 TYR n 
1 220 PHE n 
1 221 VAL n 
1 222 HIS n 
1 223 ASP n 
1 224 GLU n 
1 225 THR n 
1 226 HIS n 
1 227 VAL n 
1 228 LEU n 
1 229 GLN n 
1 230 VAL n 
1 231 ASP n 
1 232 ASP n 
1 233 VAL n 
1 234 LYS n 
1 235 GLN n 
1 236 LEU n 
1 237 ILE n 
1 238 ASP n 
1 239 ARG n 
1 240 GLY n 
1 241 ILE n 
1 242 GLY n 
1 243 VAL n 
1 244 ARG n 
1 245 MET n 
1 246 GLU n 
1 247 ARG n 
1 248 LYS n 
1 249 GLY n 
1 250 VAL n 
1 251 SER n 
1 252 GLY n 
1 253 GLN n 
1 254 THR n 
1 255 GLN n 
1 256 ASN n 
1 257 GLN n 
1 258 LEU n 
1 259 PHE n 
1 260 THR n 
1 261 TYR n 
1 262 GLU n 
1 263 MET n 
1 264 ARG n 
1 265 ILE n 
1 266 ASN n 
1 267 ASN n 
1 268 PRO n 
1 269 ALA n 
1 270 LEU n 
1 271 THR n 
1 272 SER n 
1 273 GLN n 
1 274 VAL n 
1 275 MET n 
1 276 ILE n 
1 277 ALA n 
1 278 SER n 
1 279 ALA n 
1 280 ARG n 
1 281 ALA n 
1 282 ALA n 
1 283 MET n 
1 284 ARG n 
1 285 GLN n 
1 286 LYS n 
1 287 PRO n 
1 288 GLY n 
1 289 ALA n 
1 290 TYR n 
1 291 THR n 
1 292 MET n 
1 293 ILE n 
1 294 GLU n 
1 295 ILE n 
1 296 PRO n 
1 297 ILE n 
1 298 ILE n 
1 299 ASP n 
1 300 PHE n 
1 301 LEU n 
1 302 TYR n 
1 303 GLY n 
1 304 ASP n 
1 305 ARG n 
1 306 ASP n 
1 307 GLU n 
1 308 LEU n 
1 309 ILE n 
1 310 ARG n 
1 311 ARG n 
1 312 LEU n 
1 313 VAL n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   313 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 BAA01_00405 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Bacillus thermozeamaize' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     230954 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                            ?                                            
'C3 H7 N O2'        89.093  
ARG 'L-peptide linking' y ARGININE                                           ?                                            
'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE                                         ?                                            
'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                    ?                                            
'C4 H7 N O4'        133.103 
CYS 'L-peptide linking' y CYSTEINE                                           ?                                            
'C3 H7 N O2 S'      121.158 
GLN 'L-peptide linking' y GLUTAMINE                                          ?                                            
'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                    ?                                            
'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                                            ?                                            
'C2 H5 N O2'        75.067  
HIS 'L-peptide linking' y HISTIDINE                                          ?                                            
'C6 H10 N3 O2 1'    156.162 
HOH non-polymer         . WATER                                              ?                                            'H2 O' 
18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                         ?                                            
'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                                            ?                                            
'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                                             ?                                            
'C6 H15 N2 O2 1'    147.195 
MET 'L-peptide linking' y METHIONINE                                         ?                                            
'C5 H11 N O2 S'     149.211 
NAP non-polymer         . 'NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE' 
;2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE
;
'C21 H28 N7 O17 P3' 743.405 
PHE 'L-peptide linking' y PHENYLALANINE                                      ?                                            
'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE                                            ?                                            
'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE                                             ?                                            
'C3 H7 N O3'        105.093 
THR 'L-peptide linking' y THREONINE                                          ?                                            
'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                         ?                                            
'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                                           ?                                            
'C9 H11 N O3'       181.189 
VAL 'L-peptide linking' y VALINE                                             ?                                            
'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -5  ?   ?   ?   A . n 
A 1 2   HIS 2   -4  ?   ?   ?   A . n 
A 1 3   HIS 3   -3  ?   ?   ?   A . n 
A 1 4   HIS 4   -2  ?   ?   ?   A . n 
A 1 5   HIS 5   -1  ?   ?   ?   A . n 
A 1 6   HIS 6   0   ?   ?   ?   A . n 
A 1 7   HIS 7   1   ?   ?   ?   A . n 
A 1 8   SER 8   2   ?   ?   ?   A . n 
A 1 9   GLU 9   3   ?   ?   ?   A . n 
A 1 10  ILE 10  4   ?   ?   ?   A . n 
A 1 11  ARG 11  5   ?   ?   ?   A . n 
A 1 12  THR 12  6   6   THR THR A . n 
A 1 13  GLU 13  7   7   GLU GLU A . n 
A 1 14  ARG 14  8   8   ARG ARG A . n 
A 1 15  PRO 15  9   9   PRO PRO A . n 
A 1 16  ILE 16  10  10  ILE ILE A . n 
A 1 17  ARG 17  11  11  ARG ARG A . n 
A 1 18  VAL 18  12  12  VAL VAL A . n 
A 1 19  ALA 19  13  13  ALA ALA A . n 
A 1 20  ILE 20  14  14  ILE ILE A . n 
A 1 21  ILE 21  15  15  ILE ILE A . n 
A 1 22  GLY 22  16  16  GLY GLY A . n 
A 1 23  TYR 23  17  17  TYR TYR A . n 
A 1 24  GLY 24  18  18  GLY GLY A . n 
A 1 25  ASN 25  19  19  ASN ASN A . n 
A 1 26  ILE 26  20  20  ILE ILE A . n 
A 1 27  GLY 27  21  21  GLY GLY A . n 
A 1 28  GLN 28  22  22  GLN GLN A . n 
A 1 29  TYR 29  23  23  TYR TYR A . n 
A 1 30  ALA 30  24  24  ALA ALA A . n 
A 1 31  LEU 31  25  25  LEU LEU A . n 
A 1 32  GLN 32  26  26  GLN GLN A . n 
A 1 33  ALA 33  27  27  ALA ALA A . n 
A 1 34  VAL 34  28  28  VAL VAL A . n 
A 1 35  GLU 35  29  29  GLU GLU A . n 
A 1 36  GLU 36  30  30  GLU GLU A . n 
A 1 37  ALA 37  31  31  ALA ALA A . n 
A 1 38  PRO 38  32  32  PRO PRO A . n 
A 1 39  ASP 39  33  33  ASP ASP A . n 
A 1 40  MET 40  34  34  MET MET A . n 
A 1 41  GLU 41  35  35  GLU GLU A . n 
A 1 42  LEU 42  36  36  LEU LEU A . n 
A 1 43  ALA 43  37  37  ALA ALA A . n 
A 1 44  GLY 44  38  38  GLY GLY A . n 
A 1 45  VAL 45  39  39  VAL VAL A . n 
A 1 46  VAL 46  40  40  VAL VAL A . n 
A 1 47  ARG 47  41  41  ARG ARG A . n 
A 1 48  ARG 48  42  42  ARG ARG A . n 
A 1 49  GLN 49  43  43  GLN GLN A . n 
A 1 50  SER 50  44  44  SER SER A . n 
A 1 51  SER 51  45  45  SER SER A . n 
A 1 52  LEU 52  46  46  LEU LEU A . n 
A 1 53  GLU 53  47  47  GLU GLU A . n 
A 1 54  LYS 54  48  48  LYS LYS A . n 
A 1 55  PRO 55  49  49  PRO PRO A . n 
A 1 56  LEU 56  50  50  LEU LEU A . n 
A 1 57  PRO 57  51  51  PRO PRO A . n 
A 1 58  ARG 58  52  52  ARG ARG A . n 
A 1 59  GLU 59  53  53  GLU GLU A . n 
A 1 60  LEU 60  54  54  LEU LEU A . n 
A 1 61  HIS 61  55  55  HIS HIS A . n 
A 1 62  GLY 62  56  56  GLY GLY A . n 
A 1 63  VAL 63  57  57  VAL VAL A . n 
A 1 64  SER 64  58  58  SER SER A . n 
A 1 65  VAL 65  59  59  VAL VAL A . n 
A 1 66  VAL 66  60  60  VAL VAL A . n 
A 1 67  SER 67  61  61  SER SER A . n 
A 1 68  ASP 68  62  62  ASP ASP A . n 
A 1 69  VAL 69  63  63  VAL VAL A . n 
A 1 70  SER 70  64  64  SER SER A . n 
A 1 71  ALA 71  65  65  ALA ALA A . n 
A 1 72  LEU 72  66  66  LEU LEU A . n 
A 1 73  GLY 73  67  67  GLY GLY A . n 
A 1 74  GLN 74  68  68  GLN GLN A . n 
A 1 75  VAL 75  69  69  VAL VAL A . n 
A 1 76  ASP 76  70  70  ASP ASP A . n 
A 1 77  VAL 77  71  71  VAL VAL A . n 
A 1 78  ALA 78  72  72  ALA ALA A . n 
A 1 79  VAL 79  73  73  VAL VAL A . n 
A 1 80  LEU 80  74  74  LEU LEU A . n 
A 1 81  CYS 81  75  75  CYS CYS A . n 
A 1 82  THR 82  76  76  THR THR A . n 
A 1 83  PRO 83  77  77  PRO PRO A . n 
A 1 84  THR 84  78  78  THR THR A . n 
A 1 85  ARG 85  79  79  ARG ARG A . n 
A 1 86  GLU 86  80  80  GLU GLU A . n 
A 1 87  THR 87  81  81  THR THR A . n 
A 1 88  PRO 88  82  82  PRO PRO A . n 
A 1 89  ALA 89  83  83  ALA ALA A . n 
A 1 90  ILE 90  84  84  ILE ILE A . n 
A 1 91  ALA 91  85  85  ALA ALA A . n 
A 1 92  LYS 92  86  86  LYS LYS A . n 
A 1 93  GLU 93  87  87  GLU GLU A . n 
A 1 94  LEU 94  88  88  LEU LEU A . n 
A 1 95  LEU 95  89  89  LEU LEU A . n 
A 1 96  ALA 96  90  90  ALA ALA A . n 
A 1 97  ARG 97  91  91  ARG ARG A . n 
A 1 98  GLY 98  92  92  GLY GLY A . n 
A 1 99  ILE 99  93  93  ILE ILE A . n 
A 1 100 HIS 100 94  94  HIS HIS A . n 
A 1 101 THR 101 95  95  THR THR A . n 
A 1 102 ILE 102 96  96  ILE ILE A . n 
A 1 103 ASP 103 97  97  ASP ASP A . n 
A 1 104 SER 104 98  98  SER SER A . n 
A 1 105 PHE 105 99  99  PHE PHE A . n 
A 1 106 ASP 106 100 100 ASP ASP A . n 
A 1 107 ILE 107 101 101 ILE ILE A . n 
A 1 108 HIS 108 102 102 HIS HIS A . n 
A 1 109 GLN 109 103 103 GLN GLN A . n 
A 1 110 GLU 110 104 104 GLU GLU A . n 
A 1 111 ILE 111 105 105 ILE ILE A . n 
A 1 112 VAL 112 106 106 VAL VAL A . n 
A 1 113 GLN 113 107 107 GLN GLN A . n 
A 1 114 VAL 114 108 108 VAL VAL A . n 
A 1 115 ARG 115 109 109 ARG ARG A . n 
A 1 116 HIS 116 110 110 HIS HIS A . n 
A 1 117 GLU 117 111 111 GLU GLU A . n 
A 1 118 LEU 118 112 112 LEU LEU A . n 
A 1 119 ASP 119 113 113 ASP ASP A . n 
A 1 120 GLU 120 114 114 GLU GLU A . n 
A 1 121 VAL 121 115 115 VAL VAL A . n 
A 1 122 ALA 122 116 116 ALA ALA A . n 
A 1 123 ARG 123 117 117 ARG ARG A . n 
A 1 124 ALA 124 118 118 ALA ALA A . n 
A 1 125 HIS 125 119 119 HIS HIS A . n 
A 1 126 GLN 126 120 120 GLN GLN A . n 
A 1 127 ALA 127 121 121 ALA ALA A . n 
A 1 128 VAL 128 122 122 VAL VAL A . n 
A 1 129 ALA 129 123 123 ALA ALA A . n 
A 1 130 ILE 130 124 124 ILE ILE A . n 
A 1 131 LEU 131 125 125 LEU LEU A . n 
A 1 132 ALA 132 126 126 ALA ALA A . n 
A 1 133 ALA 133 127 127 ALA ALA A . n 
A 1 134 GLY 134 128 128 GLY GLY A . n 
A 1 135 THR 135 129 129 THR THR A . n 
A 1 136 ASP 136 130 130 ASP ASP A . n 
A 1 137 PRO 137 131 131 PRO PRO A . n 
A 1 138 GLY 138 132 132 GLY GLY A . n 
A 1 139 THR 139 133 133 THR THR A . n 
A 1 140 CYS 140 134 134 CYS CYS A . n 
A 1 141 SER 141 135 135 SER SER A . n 
A 1 142 MET 142 136 136 MET MET A . n 
A 1 143 ILE 143 137 137 ILE ILE A . n 
A 1 144 ARG 144 138 138 ARG ARG A . n 
A 1 145 SER 145 139 139 SER SER A . n 
A 1 146 ILE 146 140 140 ILE ILE A . n 
A 1 147 LEU 147 141 141 LEU LEU A . n 
A 1 148 GLU 148 142 142 GLU GLU A . n 
A 1 149 PHE 149 143 143 PHE PHE A . n 
A 1 150 MET 150 144 144 MET MET A . n 
A 1 151 ALA 151 145 145 ALA ALA A . n 
A 1 152 PRO 152 146 146 PRO PRO A . n 
A 1 153 TYR 153 147 147 TYR TYR A . n 
A 1 154 GLY 154 148 148 GLY GLY A . n 
A 1 155 ILE 155 149 149 ILE ILE A . n 
A 1 156 THR 156 150 150 THR THR A . n 
A 1 157 TYR 157 151 151 TYR TYR A . n 
A 1 158 THR 158 152 152 THR THR A . n 
A 1 159 ASN 159 153 153 ASN ASN A . n 
A 1 160 VAL 160 154 154 VAL VAL A . n 
A 1 161 GLY 161 155 155 GLY GLY A . n 
A 1 162 PRO 162 156 156 PRO PRO A . n 
A 1 163 GLY 163 157 157 GLY GLY A . n 
A 1 164 MET 164 158 158 MET MET A . n 
A 1 165 SER 165 159 159 SER SER A . n 
A 1 166 MET 166 160 160 MET MET A . n 
A 1 167 GLY 167 161 161 GLY GLY A . n 
A 1 168 HIS 168 162 162 HIS HIS A . n 
A 1 169 SER 169 163 163 SER SER A . n 
A 1 170 VAL 170 164 164 VAL VAL A . n 
A 1 171 ALA 171 165 165 ALA ALA A . n 
A 1 172 VAL 172 166 166 VAL VAL A . n 
A 1 173 LYS 173 167 167 LYS LYS A . n 
A 1 174 ALA 174 168 168 ALA ALA A . n 
A 1 175 ILE 175 169 169 ILE ILE A . n 
A 1 176 GLU 176 170 170 GLU GLU A . n 
A 1 177 GLY 177 171 171 GLY GLY A . n 
A 1 178 VAL 178 172 172 VAL VAL A . n 
A 1 179 LYS 179 173 173 LYS LYS A . n 
A 1 180 ASP 180 174 174 ASP ASP A . n 
A 1 181 ALA 181 175 175 ALA ALA A . n 
A 1 182 LEU 182 176 176 LEU LEU A . n 
A 1 183 ALA 183 177 177 ALA ALA A . n 
A 1 184 LEU 184 178 178 LEU LEU A . n 
A 1 185 THR 185 179 179 THR THR A . n 
A 1 186 ILE 186 180 180 ILE ILE A . n 
A 1 187 PRO 187 181 181 PRO PRO A . n 
A 1 188 ILE 188 182 182 ILE ILE A . n 
A 1 189 GLY 189 183 183 GLY GLY A . n 
A 1 190 THR 190 184 184 THR THR A . n 
A 1 191 GLY 191 185 185 GLY GLY A . n 
A 1 192 LEU 192 186 186 LEU LEU A . n 
A 1 193 HIS 193 187 187 HIS HIS A . n 
A 1 194 ARG 194 188 188 ARG ARG A . n 
A 1 195 ARG 195 189 189 ARG ARG A . n 
A 1 196 MET 196 190 190 MET MET A . n 
A 1 197 VAL 197 191 191 VAL VAL A . n 
A 1 198 TYR 198 192 192 TYR TYR A . n 
A 1 199 VAL 199 193 193 VAL VAL A . n 
A 1 200 GLU 200 194 194 GLU GLU A . n 
A 1 201 LEU 201 195 195 LEU LEU A . n 
A 1 202 GLU 202 196 ?   ?   ?   A . n 
A 1 203 GLU 203 197 ?   ?   ?   A . n 
A 1 204 GLY 204 198 ?   ?   ?   A . n 
A 1 205 ALA 205 199 ?   ?   ?   A . n 
A 1 206 ASP 206 200 ?   ?   ?   A . n 
A 1 207 PHE 207 201 ?   ?   ?   A . n 
A 1 208 ALA 208 202 ?   ?   ?   A . n 
A 1 209 THR 209 203 ?   ?   ?   A . n 
A 1 210 VAL 210 204 ?   ?   ?   A . n 
A 1 211 LYS 211 205 205 LYS LYS A . n 
A 1 212 GLU 212 206 206 GLU GLU A . n 
A 1 213 ARG 213 207 207 ARG ARG A . n 
A 1 214 ILE 214 208 208 ILE ILE A . n 
A 1 215 LEU 215 209 209 LEU LEU A . n 
A 1 216 GLN 216 210 210 GLN GLN A . n 
A 1 217 ASP 217 211 211 ASP ASP A . n 
A 1 218 PRO 218 212 212 PRO PRO A . n 
A 1 219 TYR 219 213 213 TYR TYR A . n 
A 1 220 PHE 220 214 214 PHE PHE A . n 
A 1 221 VAL 221 215 215 VAL VAL A . n 
A 1 222 HIS 222 216 216 HIS HIS A . n 
A 1 223 ASP 223 217 217 ASP ASP A . n 
A 1 224 GLU 224 218 218 GLU GLU A . n 
A 1 225 THR 225 219 219 THR THR A . n 
A 1 226 HIS 226 220 220 HIS HIS A . n 
A 1 227 VAL 227 221 221 VAL VAL A . n 
A 1 228 LEU 228 222 222 LEU LEU A . n 
A 1 229 GLN 229 223 223 GLN GLN A . n 
A 1 230 VAL 230 224 224 VAL VAL A . n 
A 1 231 ASP 231 225 225 ASP ASP A . n 
A 1 232 ASP 232 226 226 ASP ASP A . n 
A 1 233 VAL 233 227 227 VAL VAL A . n 
A 1 234 LYS 234 228 228 LYS LYS A . n 
A 1 235 GLN 235 229 229 GLN GLN A . n 
A 1 236 LEU 236 230 230 LEU LEU A . n 
A 1 237 ILE 237 231 231 ILE ILE A . n 
A 1 238 ASP 238 232 232 ASP ASP A . n 
A 1 239 ARG 239 233 233 ARG ARG A . n 
A 1 240 GLY 240 234 234 GLY GLY A . n 
A 1 241 ILE 241 235 235 ILE ILE A . n 
A 1 242 GLY 242 236 236 GLY GLY A . n 
A 1 243 VAL 243 237 237 VAL VAL A . n 
A 1 244 ARG 244 238 238 ARG ARG A . n 
A 1 245 MET 245 239 239 MET MET A . n 
A 1 246 GLU 246 240 240 GLU GLU A . n 
A 1 247 ARG 247 241 241 ARG ARG A . n 
A 1 248 LYS 248 242 242 LYS LYS A . n 
A 1 249 GLY 249 243 243 GLY GLY A . n 
A 1 250 VAL 250 244 244 VAL VAL A . n 
A 1 251 SER 251 245 245 SER SER A . n 
A 1 252 GLY 252 246 246 GLY GLY A . n 
A 1 253 GLN 253 247 247 GLN GLN A . n 
A 1 254 THR 254 248 248 THR THR A . n 
A 1 255 GLN 255 249 249 GLN GLN A . n 
A 1 256 ASN 256 250 250 ASN ASN A . n 
A 1 257 GLN 257 251 251 GLN GLN A . n 
A 1 258 LEU 258 252 252 LEU LEU A . n 
A 1 259 PHE 259 253 253 PHE PHE A . n 
A 1 260 THR 260 254 254 THR THR A . n 
A 1 261 TYR 261 255 255 TYR TYR A . n 
A 1 262 GLU 262 256 256 GLU GLU A . n 
A 1 263 MET 263 257 257 MET MET A . n 
A 1 264 ARG 264 258 258 ARG ARG A . n 
A 1 265 ILE 265 259 259 ILE ILE A . n 
A 1 266 ASN 266 260 260 ASN ASN A . n 
A 1 267 ASN 267 261 261 ASN ASN A . n 
A 1 268 PRO 268 262 262 PRO PRO A . n 
A 1 269 ALA 269 263 263 ALA ALA A . n 
A 1 270 LEU 270 264 264 LEU LEU A . n 
A 1 271 THR 271 265 265 THR THR A . n 
A 1 272 SER 272 266 266 SER SER A . n 
A 1 273 GLN 273 267 267 GLN GLN A . n 
A 1 274 VAL 274 268 268 VAL VAL A . n 
A 1 275 MET 275 269 269 MET MET A . n 
A 1 276 ILE 276 270 270 ILE ILE A . n 
A 1 277 ALA 277 271 271 ALA ALA A . n 
A 1 278 SER 278 272 272 SER SER A . n 
A 1 279 ALA 279 273 273 ALA ALA A . n 
A 1 280 ARG 280 274 274 ARG ARG A . n 
A 1 281 ALA 281 275 275 ALA ALA A . n 
A 1 282 ALA 282 276 276 ALA ALA A . n 
A 1 283 MET 283 277 277 MET MET A . n 
A 1 284 ARG 284 278 278 ARG ARG A . n 
A 1 285 GLN 285 279 279 GLN GLN A . n 
A 1 286 LYS 286 280 280 LYS LYS A . n 
A 1 287 PRO 287 281 281 PRO PRO A . n 
A 1 288 GLY 288 282 282 GLY GLY A . n 
A 1 289 ALA 289 283 283 ALA ALA A . n 
A 1 290 TYR 290 284 284 TYR TYR A . n 
A 1 291 THR 291 285 285 THR THR A . n 
A 1 292 MET 292 286 286 MET MET A . n 
A 1 293 ILE 293 287 287 ILE ILE A . n 
A 1 294 GLU 294 288 288 GLU GLU A . n 
A 1 295 ILE 295 289 289 ILE ILE A . n 
A 1 296 PRO 296 290 290 PRO PRO A . n 
A 1 297 ILE 297 291 291 ILE ILE A . n 
A 1 298 ILE 298 292 292 ILE ILE A . n 
A 1 299 ASP 299 293 293 ASP ASP A . n 
A 1 300 PHE 300 294 294 PHE PHE A . n 
A 1 301 LEU 301 295 295 LEU LEU A . n 
A 1 302 TYR 302 296 296 TYR TYR A . n 
A 1 303 GLY 303 297 297 GLY GLY A . n 
A 1 304 ASP 304 298 298 ASP ASP A . n 
A 1 305 ARG 305 299 299 ARG ARG A . n 
A 1 306 ASP 306 300 300 ASP ASP A . n 
A 1 307 GLU 307 301 301 GLU GLU A . n 
A 1 308 LEU 308 302 302 LEU LEU A . n 
A 1 309 ILE 309 303 303 ILE ILE A . n 
A 1 310 ARG 310 304 304 ARG ARG A . n 
A 1 311 ARG 311 305 305 ARG ARG A . n 
A 1 312 LEU 312 306 306 LEU LEU A . n 
A 1 313 VAL 313 307 307 VAL VAL A . n 
B 1 1   MET 1   -5  ?   ?   ?   B . n 
B 1 2   HIS 2   -4  ?   ?   ?   B . n 
B 1 3   HIS 3   -3  ?   ?   ?   B . n 
B 1 4   HIS 4   -2  ?   ?   ?   B . n 
B 1 5   HIS 5   -1  ?   ?   ?   B . n 
B 1 6   HIS 6   0   ?   ?   ?   B . n 
B 1 7   HIS 7   1   ?   ?   ?   B . n 
B 1 8   SER 8   2   ?   ?   ?   B . n 
B 1 9   GLU 9   3   ?   ?   ?   B . n 
B 1 10  ILE 10  4   ?   ?   ?   B . n 
B 1 11  ARG 11  5   ?   ?   ?   B . n 
B 1 12  THR 12  6   6   THR THR B . n 
B 1 13  GLU 13  7   7   GLU GLU B . n 
B 1 14  ARG 14  8   8   ARG ARG B . n 
B 1 15  PRO 15  9   9   PRO PRO B . n 
B 1 16  ILE 16  10  10  ILE ILE B . n 
B 1 17  ARG 17  11  11  ARG ARG B . n 
B 1 18  VAL 18  12  12  VAL VAL B . n 
B 1 19  ALA 19  13  13  ALA ALA B . n 
B 1 20  ILE 20  14  14  ILE ILE B . n 
B 1 21  ILE 21  15  15  ILE ILE B . n 
B 1 22  GLY 22  16  16  GLY GLY B . n 
B 1 23  TYR 23  17  17  TYR TYR B . n 
B 1 24  GLY 24  18  18  GLY GLY B . n 
B 1 25  ASN 25  19  19  ASN ASN B . n 
B 1 26  ILE 26  20  20  ILE ILE B . n 
B 1 27  GLY 27  21  21  GLY GLY B . n 
B 1 28  GLN 28  22  22  GLN GLN B . n 
B 1 29  TYR 29  23  23  TYR TYR B . n 
B 1 30  ALA 30  24  24  ALA ALA B . n 
B 1 31  LEU 31  25  25  LEU LEU B . n 
B 1 32  GLN 32  26  26  GLN GLN B . n 
B 1 33  ALA 33  27  27  ALA ALA B . n 
B 1 34  VAL 34  28  28  VAL VAL B . n 
B 1 35  GLU 35  29  29  GLU GLU B . n 
B 1 36  GLU 36  30  30  GLU GLU B . n 
B 1 37  ALA 37  31  31  ALA ALA B . n 
B 1 38  PRO 38  32  32  PRO PRO B . n 
B 1 39  ASP 39  33  33  ASP ASP B . n 
B 1 40  MET 40  34  34  MET MET B . n 
B 1 41  GLU 41  35  35  GLU GLU B . n 
B 1 42  LEU 42  36  36  LEU LEU B . n 
B 1 43  ALA 43  37  37  ALA ALA B . n 
B 1 44  GLY 44  38  38  GLY GLY B . n 
B 1 45  VAL 45  39  39  VAL VAL B . n 
B 1 46  VAL 46  40  40  VAL VAL B . n 
B 1 47  ARG 47  41  41  ARG ARG B . n 
B 1 48  ARG 48  42  42  ARG ARG B . n 
B 1 49  GLN 49  43  43  GLN GLN B . n 
B 1 50  SER 50  44  44  SER SER B . n 
B 1 51  SER 51  45  45  SER SER B . n 
B 1 52  LEU 52  46  46  LEU LEU B . n 
B 1 53  GLU 53  47  47  GLU GLU B . n 
B 1 54  LYS 54  48  48  LYS LYS B . n 
B 1 55  PRO 55  49  49  PRO PRO B . n 
B 1 56  LEU 56  50  50  LEU LEU B . n 
B 1 57  PRO 57  51  51  PRO PRO B . n 
B 1 58  ARG 58  52  52  ARG ARG B . n 
B 1 59  GLU 59  53  53  GLU GLU B . n 
B 1 60  LEU 60  54  54  LEU LEU B . n 
B 1 61  HIS 61  55  55  HIS HIS B . n 
B 1 62  GLY 62  56  56  GLY GLY B . n 
B 1 63  VAL 63  57  57  VAL VAL B . n 
B 1 64  SER 64  58  58  SER SER B . n 
B 1 65  VAL 65  59  59  VAL VAL B . n 
B 1 66  VAL 66  60  60  VAL VAL B . n 
B 1 67  SER 67  61  61  SER SER B . n 
B 1 68  ASP 68  62  62  ASP ASP B . n 
B 1 69  VAL 69  63  63  VAL VAL B . n 
B 1 70  SER 70  64  64  SER SER B . n 
B 1 71  ALA 71  65  65  ALA ALA B . n 
B 1 72  LEU 72  66  66  LEU LEU B . n 
B 1 73  GLY 73  67  67  GLY GLY B . n 
B 1 74  GLN 74  68  68  GLN GLN B . n 
B 1 75  VAL 75  69  69  VAL VAL B . n 
B 1 76  ASP 76  70  70  ASP ASP B . n 
B 1 77  VAL 77  71  71  VAL VAL B . n 
B 1 78  ALA 78  72  72  ALA ALA B . n 
B 1 79  VAL 79  73  73  VAL VAL B . n 
B 1 80  LEU 80  74  74  LEU LEU B . n 
B 1 81  CYS 81  75  75  CYS CYS B . n 
B 1 82  THR 82  76  76  THR THR B . n 
B 1 83  PRO 83  77  77  PRO PRO B . n 
B 1 84  THR 84  78  78  THR THR B . n 
B 1 85  ARG 85  79  79  ARG ARG B . n 
B 1 86  GLU 86  80  80  GLU GLU B . n 
B 1 87  THR 87  81  81  THR THR B . n 
B 1 88  PRO 88  82  82  PRO PRO B . n 
B 1 89  ALA 89  83  83  ALA ALA B . n 
B 1 90  ILE 90  84  84  ILE ILE B . n 
B 1 91  ALA 91  85  85  ALA ALA B . n 
B 1 92  LYS 92  86  86  LYS LYS B . n 
B 1 93  GLU 93  87  87  GLU GLU B . n 
B 1 94  LEU 94  88  88  LEU LEU B . n 
B 1 95  LEU 95  89  89  LEU LEU B . n 
B 1 96  ALA 96  90  90  ALA ALA B . n 
B 1 97  ARG 97  91  91  ARG ARG B . n 
B 1 98  GLY 98  92  92  GLY GLY B . n 
B 1 99  ILE 99  93  93  ILE ILE B . n 
B 1 100 HIS 100 94  94  HIS HIS B . n 
B 1 101 THR 101 95  95  THR THR B . n 
B 1 102 ILE 102 96  96  ILE ILE B . n 
B 1 103 ASP 103 97  97  ASP ASP B . n 
B 1 104 SER 104 98  98  SER SER B . n 
B 1 105 PHE 105 99  99  PHE PHE B . n 
B 1 106 ASP 106 100 100 ASP ASP B . n 
B 1 107 ILE 107 101 101 ILE ILE B . n 
B 1 108 HIS 108 102 102 HIS HIS B . n 
B 1 109 GLN 109 103 103 GLN GLN B . n 
B 1 110 GLU 110 104 104 GLU GLU B . n 
B 1 111 ILE 111 105 105 ILE ILE B . n 
B 1 112 VAL 112 106 106 VAL VAL B . n 
B 1 113 GLN 113 107 107 GLN GLN B . n 
B 1 114 VAL 114 108 108 VAL VAL B . n 
B 1 115 ARG 115 109 109 ARG ARG B . n 
B 1 116 HIS 116 110 110 HIS HIS B . n 
B 1 117 GLU 117 111 111 GLU GLU B . n 
B 1 118 LEU 118 112 112 LEU LEU B . n 
B 1 119 ASP 119 113 113 ASP ASP B . n 
B 1 120 GLU 120 114 114 GLU GLU B . n 
B 1 121 VAL 121 115 115 VAL VAL B . n 
B 1 122 ALA 122 116 116 ALA ALA B . n 
B 1 123 ARG 123 117 117 ARG ARG B . n 
B 1 124 ALA 124 118 118 ALA ALA B . n 
B 1 125 HIS 125 119 119 HIS HIS B . n 
B 1 126 GLN 126 120 120 GLN GLN B . n 
B 1 127 ALA 127 121 121 ALA ALA B . n 
B 1 128 VAL 128 122 122 VAL VAL B . n 
B 1 129 ALA 129 123 123 ALA ALA B . n 
B 1 130 ILE 130 124 124 ILE ILE B . n 
B 1 131 LEU 131 125 125 LEU LEU B . n 
B 1 132 ALA 132 126 126 ALA ALA B . n 
B 1 133 ALA 133 127 127 ALA ALA B . n 
B 1 134 GLY 134 128 128 GLY GLY B . n 
B 1 135 THR 135 129 129 THR THR B . n 
B 1 136 ASP 136 130 130 ASP ASP B . n 
B 1 137 PRO 137 131 131 PRO PRO B . n 
B 1 138 GLY 138 132 132 GLY GLY B . n 
B 1 139 THR 139 133 133 THR THR B . n 
B 1 140 CYS 140 134 134 CYS CYS B . n 
B 1 141 SER 141 135 135 SER SER B . n 
B 1 142 MET 142 136 136 MET MET B . n 
B 1 143 ILE 143 137 137 ILE ILE B . n 
B 1 144 ARG 144 138 138 ARG ARG B . n 
B 1 145 SER 145 139 139 SER SER B . n 
B 1 146 ILE 146 140 140 ILE ILE B . n 
B 1 147 LEU 147 141 141 LEU LEU B . n 
B 1 148 GLU 148 142 142 GLU GLU B . n 
B 1 149 PHE 149 143 143 PHE PHE B . n 
B 1 150 MET 150 144 144 MET MET B . n 
B 1 151 ALA 151 145 145 ALA ALA B . n 
B 1 152 PRO 152 146 146 PRO PRO B . n 
B 1 153 TYR 153 147 147 TYR TYR B . n 
B 1 154 GLY 154 148 148 GLY GLY B . n 
B 1 155 ILE 155 149 149 ILE ILE B . n 
B 1 156 THR 156 150 150 THR THR B . n 
B 1 157 TYR 157 151 151 TYR TYR B . n 
B 1 158 THR 158 152 152 THR THR B . n 
B 1 159 ASN 159 153 153 ASN ASN B . n 
B 1 160 VAL 160 154 154 VAL VAL B . n 
B 1 161 GLY 161 155 155 GLY GLY B . n 
B 1 162 PRO 162 156 156 PRO PRO B . n 
B 1 163 GLY 163 157 157 GLY GLY B . n 
B 1 164 MET 164 158 158 MET MET B . n 
B 1 165 SER 165 159 159 SER SER B . n 
B 1 166 MET 166 160 160 MET MET B . n 
B 1 167 GLY 167 161 161 GLY GLY B . n 
B 1 168 HIS 168 162 162 HIS HIS B . n 
B 1 169 SER 169 163 163 SER SER B . n 
B 1 170 VAL 170 164 164 VAL VAL B . n 
B 1 171 ALA 171 165 165 ALA ALA B . n 
B 1 172 VAL 172 166 166 VAL VAL B . n 
B 1 173 LYS 173 167 167 LYS LYS B . n 
B 1 174 ALA 174 168 168 ALA ALA B . n 
B 1 175 ILE 175 169 169 ILE ILE B . n 
B 1 176 GLU 176 170 170 GLU GLU B . n 
B 1 177 GLY 177 171 171 GLY GLY B . n 
B 1 178 VAL 178 172 172 VAL VAL B . n 
B 1 179 LYS 179 173 173 LYS LYS B . n 
B 1 180 ASP 180 174 174 ASP ASP B . n 
B 1 181 ALA 181 175 175 ALA ALA B . n 
B 1 182 LEU 182 176 176 LEU LEU B . n 
B 1 183 ALA 183 177 177 ALA ALA B . n 
B 1 184 LEU 184 178 178 LEU LEU B . n 
B 1 185 THR 185 179 179 THR THR B . n 
B 1 186 ILE 186 180 180 ILE ILE B . n 
B 1 187 PRO 187 181 181 PRO PRO B . n 
B 1 188 ILE 188 182 182 ILE ILE B . n 
B 1 189 GLY 189 183 183 GLY GLY B . n 
B 1 190 THR 190 184 184 THR THR B . n 
B 1 191 GLY 191 185 185 GLY GLY B . n 
B 1 192 LEU 192 186 186 LEU LEU B . n 
B 1 193 HIS 193 187 187 HIS HIS B . n 
B 1 194 ARG 194 188 188 ARG ARG B . n 
B 1 195 ARG 195 189 189 ARG ARG B . n 
B 1 196 MET 196 190 190 MET MET B . n 
B 1 197 VAL 197 191 191 VAL VAL B . n 
B 1 198 TYR 198 192 192 TYR TYR B . n 
B 1 199 VAL 199 193 193 VAL VAL B . n 
B 1 200 GLU 200 194 194 GLU GLU B . n 
B 1 201 LEU 201 195 ?   ?   ?   B . n 
B 1 202 GLU 202 196 ?   ?   ?   B . n 
B 1 203 GLU 203 197 ?   ?   ?   B . n 
B 1 204 GLY 204 198 ?   ?   ?   B . n 
B 1 205 ALA 205 199 ?   ?   ?   B . n 
B 1 206 ASP 206 200 ?   ?   ?   B . n 
B 1 207 PHE 207 201 ?   ?   ?   B . n 
B 1 208 ALA 208 202 ?   ?   ?   B . n 
B 1 209 THR 209 203 ?   ?   ?   B . n 
B 1 210 VAL 210 204 ?   ?   ?   B . n 
B 1 211 LYS 211 205 ?   ?   ?   B . n 
B 1 212 GLU 212 206 206 GLU GLU B . n 
B 1 213 ARG 213 207 207 ARG ARG B . n 
B 1 214 ILE 214 208 208 ILE ILE B . n 
B 1 215 LEU 215 209 209 LEU LEU B . n 
B 1 216 GLN 216 210 210 GLN GLN B . n 
B 1 217 ASP 217 211 211 ASP ASP B . n 
B 1 218 PRO 218 212 ?   ?   ?   B . n 
B 1 219 TYR 219 213 ?   ?   ?   B . n 
B 1 220 PHE 220 214 ?   ?   ?   B . n 
B 1 221 VAL 221 215 ?   ?   ?   B . n 
B 1 222 HIS 222 216 ?   ?   ?   B . n 
B 1 223 ASP 223 217 217 ASP ASP B . n 
B 1 224 GLU 224 218 218 GLU GLU B . n 
B 1 225 THR 225 219 219 THR THR B . n 
B 1 226 HIS 226 220 220 HIS HIS B . n 
B 1 227 VAL 227 221 221 VAL VAL B . n 
B 1 228 LEU 228 222 222 LEU LEU B . n 
B 1 229 GLN 229 223 223 GLN GLN B . n 
B 1 230 VAL 230 224 224 VAL VAL B . n 
B 1 231 ASP 231 225 225 ASP ASP B . n 
B 1 232 ASP 232 226 226 ASP ASP B . n 
B 1 233 VAL 233 227 227 VAL VAL B . n 
B 1 234 LYS 234 228 228 LYS LYS B . n 
B 1 235 GLN 235 229 229 GLN GLN B . n 
B 1 236 LEU 236 230 230 LEU LEU B . n 
B 1 237 ILE 237 231 231 ILE ILE B . n 
B 1 238 ASP 238 232 232 ASP ASP B . n 
B 1 239 ARG 239 233 233 ARG ARG B . n 
B 1 240 GLY 240 234 234 GLY GLY B . n 
B 1 241 ILE 241 235 235 ILE ILE B . n 
B 1 242 GLY 242 236 236 GLY GLY B . n 
B 1 243 VAL 243 237 237 VAL VAL B . n 
B 1 244 ARG 244 238 238 ARG ARG B . n 
B 1 245 MET 245 239 239 MET MET B . n 
B 1 246 GLU 246 240 240 GLU GLU B . n 
B 1 247 ARG 247 241 241 ARG ARG B . n 
B 1 248 LYS 248 242 242 LYS LYS B . n 
B 1 249 GLY 249 243 243 GLY GLY B . n 
B 1 250 VAL 250 244 244 VAL VAL B . n 
B 1 251 SER 251 245 245 SER SER B . n 
B 1 252 GLY 252 246 246 GLY GLY B . n 
B 1 253 GLN 253 247 247 GLN GLN B . n 
B 1 254 THR 254 248 248 THR THR B . n 
B 1 255 GLN 255 249 249 GLN GLN B . n 
B 1 256 ASN 256 250 250 ASN ASN B . n 
B 1 257 GLN 257 251 251 GLN GLN B . n 
B 1 258 LEU 258 252 252 LEU LEU B . n 
B 1 259 PHE 259 253 253 PHE PHE B . n 
B 1 260 THR 260 254 254 THR THR B . n 
B 1 261 TYR 261 255 255 TYR TYR B . n 
B 1 262 GLU 262 256 256 GLU GLU B . n 
B 1 263 MET 263 257 257 MET MET B . n 
B 1 264 ARG 264 258 258 ARG ARG B . n 
B 1 265 ILE 265 259 259 ILE ILE B . n 
B 1 266 ASN 266 260 260 ASN ASN B . n 
B 1 267 ASN 267 261 261 ASN ASN B . n 
B 1 268 PRO 268 262 262 PRO PRO B . n 
B 1 269 ALA 269 263 263 ALA ALA B . n 
B 1 270 LEU 270 264 264 LEU LEU B . n 
B 1 271 THR 271 265 265 THR THR B . n 
B 1 272 SER 272 266 266 SER SER B . n 
B 1 273 GLN 273 267 267 GLN GLN B . n 
B 1 274 VAL 274 268 268 VAL VAL B . n 
B 1 275 MET 275 269 269 MET MET B . n 
B 1 276 ILE 276 270 270 ILE ILE B . n 
B 1 277 ALA 277 271 271 ALA ALA B . n 
B 1 278 SER 278 272 272 SER SER B . n 
B 1 279 ALA 279 273 273 ALA ALA B . n 
B 1 280 ARG 280 274 274 ARG ARG B . n 
B 1 281 ALA 281 275 275 ALA ALA B . n 
B 1 282 ALA 282 276 276 ALA ALA B . n 
B 1 283 MET 283 277 277 MET MET B . n 
B 1 284 ARG 284 278 278 ARG ARG B . n 
B 1 285 GLN 285 279 279 GLN GLN B . n 
B 1 286 LYS 286 280 280 LYS LYS B . n 
B 1 287 PRO 287 281 281 PRO PRO B . n 
B 1 288 GLY 288 282 282 GLY GLY B . n 
B 1 289 ALA 289 283 283 ALA ALA B . n 
B 1 290 TYR 290 284 284 TYR TYR B . n 
B 1 291 THR 291 285 285 THR THR B . n 
B 1 292 MET 292 286 286 MET MET B . n 
B 1 293 ILE 293 287 287 ILE ILE B . n 
B 1 294 GLU 294 288 288 GLU GLU B . n 
B 1 295 ILE 295 289 289 ILE ILE B . n 
B 1 296 PRO 296 290 290 PRO PRO B . n 
B 1 297 ILE 297 291 291 ILE ILE B . n 
B 1 298 ILE 298 292 292 ILE ILE B . n 
B 1 299 ASP 299 293 293 ASP ASP B . n 
B 1 300 PHE 300 294 294 PHE PHE B . n 
B 1 301 LEU 301 295 295 LEU LEU B . n 
B 1 302 TYR 302 296 296 TYR TYR B . n 
B 1 303 GLY 303 297 297 GLY GLY B . n 
B 1 304 ASP 304 298 298 ASP ASP B . n 
B 1 305 ARG 305 299 299 ARG ARG B . n 
B 1 306 ASP 306 300 300 ASP ASP B . n 
B 1 307 GLU 307 301 301 GLU GLU B . n 
B 1 308 LEU 308 302 302 LEU LEU B . n 
B 1 309 ILE 309 303 303 ILE ILE B . n 
B 1 310 ARG 310 304 304 ARG ARG B . n 
B 1 311 ARG 311 305 305 ARG ARG B . n 
B 1 312 LEU 312 306 306 LEU LEU B . n 
B 1 313 VAL 313 307 307 VAL VAL B . n 
C 1 1   MET 1   -5  ?   ?   ?   C . n 
C 1 2   HIS 2   -4  ?   ?   ?   C . n 
C 1 3   HIS 3   -3  ?   ?   ?   C . n 
C 1 4   HIS 4   -2  ?   ?   ?   C . n 
C 1 5   HIS 5   -1  ?   ?   ?   C . n 
C 1 6   HIS 6   0   ?   ?   ?   C . n 
C 1 7   HIS 7   1   ?   ?   ?   C . n 
C 1 8   SER 8   2   ?   ?   ?   C . n 
C 1 9   GLU 9   3   ?   ?   ?   C . n 
C 1 10  ILE 10  4   ?   ?   ?   C . n 
C 1 11  ARG 11  5   5   ARG ARG C . n 
C 1 12  THR 12  6   6   THR THR C . n 
C 1 13  GLU 13  7   7   GLU GLU C . n 
C 1 14  ARG 14  8   8   ARG ARG C . n 
C 1 15  PRO 15  9   9   PRO PRO C . n 
C 1 16  ILE 16  10  10  ILE ILE C . n 
C 1 17  ARG 17  11  11  ARG ARG C . n 
C 1 18  VAL 18  12  12  VAL VAL C . n 
C 1 19  ALA 19  13  13  ALA ALA C . n 
C 1 20  ILE 20  14  14  ILE ILE C . n 
C 1 21  ILE 21  15  15  ILE ILE C . n 
C 1 22  GLY 22  16  16  GLY GLY C . n 
C 1 23  TYR 23  17  17  TYR TYR C . n 
C 1 24  GLY 24  18  18  GLY GLY C . n 
C 1 25  ASN 25  19  19  ASN ASN C . n 
C 1 26  ILE 26  20  20  ILE ILE C . n 
C 1 27  GLY 27  21  21  GLY GLY C . n 
C 1 28  GLN 28  22  22  GLN GLN C . n 
C 1 29  TYR 29  23  23  TYR TYR C . n 
C 1 30  ALA 30  24  24  ALA ALA C . n 
C 1 31  LEU 31  25  25  LEU LEU C . n 
C 1 32  GLN 32  26  26  GLN GLN C . n 
C 1 33  ALA 33  27  27  ALA ALA C . n 
C 1 34  VAL 34  28  28  VAL VAL C . n 
C 1 35  GLU 35  29  29  GLU GLU C . n 
C 1 36  GLU 36  30  30  GLU GLU C . n 
C 1 37  ALA 37  31  31  ALA ALA C . n 
C 1 38  PRO 38  32  32  PRO PRO C . n 
C 1 39  ASP 39  33  33  ASP ASP C . n 
C 1 40  MET 40  34  34  MET MET C . n 
C 1 41  GLU 41  35  35  GLU GLU C . n 
C 1 42  LEU 42  36  36  LEU LEU C . n 
C 1 43  ALA 43  37  37  ALA ALA C . n 
C 1 44  GLY 44  38  38  GLY GLY C . n 
C 1 45  VAL 45  39  39  VAL VAL C . n 
C 1 46  VAL 46  40  40  VAL VAL C . n 
C 1 47  ARG 47  41  41  ARG ARG C . n 
C 1 48  ARG 48  42  42  ARG ARG C . n 
C 1 49  GLN 49  43  43  GLN GLN C . n 
C 1 50  SER 50  44  44  SER SER C . n 
C 1 51  SER 51  45  45  SER SER C . n 
C 1 52  LEU 52  46  46  LEU LEU C . n 
C 1 53  GLU 53  47  47  GLU GLU C . n 
C 1 54  LYS 54  48  48  LYS LYS C . n 
C 1 55  PRO 55  49  49  PRO PRO C . n 
C 1 56  LEU 56  50  50  LEU LEU C . n 
C 1 57  PRO 57  51  51  PRO PRO C . n 
C 1 58  ARG 58  52  ?   ?   ?   C . n 
C 1 59  GLU 59  53  ?   ?   ?   C . n 
C 1 60  LEU 60  54  ?   ?   ?   C . n 
C 1 61  HIS 61  55  ?   ?   ?   C . n 
C 1 62  GLY 62  56  56  GLY GLY C . n 
C 1 63  VAL 63  57  57  VAL VAL C . n 
C 1 64  SER 64  58  58  SER SER C . n 
C 1 65  VAL 65  59  59  VAL VAL C . n 
C 1 66  VAL 66  60  60  VAL VAL C . n 
C 1 67  SER 67  61  61  SER SER C . n 
C 1 68  ASP 68  62  62  ASP ASP C . n 
C 1 69  VAL 69  63  63  VAL VAL C . n 
C 1 70  SER 70  64  64  SER SER C . n 
C 1 71  ALA 71  65  65  ALA ALA C . n 
C 1 72  LEU 72  66  66  LEU LEU C . n 
C 1 73  GLY 73  67  67  GLY GLY C . n 
C 1 74  GLN 74  68  68  GLN GLN C . n 
C 1 75  VAL 75  69  69  VAL VAL C . n 
C 1 76  ASP 76  70  70  ASP ASP C . n 
C 1 77  VAL 77  71  71  VAL VAL C . n 
C 1 78  ALA 78  72  72  ALA ALA C . n 
C 1 79  VAL 79  73  73  VAL VAL C . n 
C 1 80  LEU 80  74  74  LEU LEU C . n 
C 1 81  CYS 81  75  75  CYS CYS C . n 
C 1 82  THR 82  76  76  THR THR C . n 
C 1 83  PRO 83  77  77  PRO PRO C . n 
C 1 84  THR 84  78  78  THR THR C . n 
C 1 85  ARG 85  79  79  ARG ARG C . n 
C 1 86  GLU 86  80  80  GLU GLU C . n 
C 1 87  THR 87  81  81  THR THR C . n 
C 1 88  PRO 88  82  82  PRO PRO C . n 
C 1 89  ALA 89  83  83  ALA ALA C . n 
C 1 90  ILE 90  84  84  ILE ILE C . n 
C 1 91  ALA 91  85  85  ALA ALA C . n 
C 1 92  LYS 92  86  86  LYS LYS C . n 
C 1 93  GLU 93  87  87  GLU GLU C . n 
C 1 94  LEU 94  88  88  LEU LEU C . n 
C 1 95  LEU 95  89  89  LEU LEU C . n 
C 1 96  ALA 96  90  90  ALA ALA C . n 
C 1 97  ARG 97  91  91  ARG ARG C . n 
C 1 98  GLY 98  92  92  GLY GLY C . n 
C 1 99  ILE 99  93  93  ILE ILE C . n 
C 1 100 HIS 100 94  94  HIS HIS C . n 
C 1 101 THR 101 95  95  THR THR C . n 
C 1 102 ILE 102 96  96  ILE ILE C . n 
C 1 103 ASP 103 97  97  ASP ASP C . n 
C 1 104 SER 104 98  98  SER SER C . n 
C 1 105 PHE 105 99  99  PHE PHE C . n 
C 1 106 ASP 106 100 100 ASP ASP C . n 
C 1 107 ILE 107 101 101 ILE ILE C . n 
C 1 108 HIS 108 102 102 HIS HIS C . n 
C 1 109 GLN 109 103 103 GLN GLN C . n 
C 1 110 GLU 110 104 104 GLU GLU C . n 
C 1 111 ILE 111 105 105 ILE ILE C . n 
C 1 112 VAL 112 106 106 VAL VAL C . n 
C 1 113 GLN 113 107 107 GLN GLN C . n 
C 1 114 VAL 114 108 108 VAL VAL C . n 
C 1 115 ARG 115 109 109 ARG ARG C . n 
C 1 116 HIS 116 110 110 HIS HIS C . n 
C 1 117 GLU 117 111 111 GLU GLU C . n 
C 1 118 LEU 118 112 112 LEU LEU C . n 
C 1 119 ASP 119 113 113 ASP ASP C . n 
C 1 120 GLU 120 114 114 GLU GLU C . n 
C 1 121 VAL 121 115 115 VAL VAL C . n 
C 1 122 ALA 122 116 116 ALA ALA C . n 
C 1 123 ARG 123 117 117 ARG ARG C . n 
C 1 124 ALA 124 118 118 ALA ALA C . n 
C 1 125 HIS 125 119 119 HIS HIS C . n 
C 1 126 GLN 126 120 120 GLN GLN C . n 
C 1 127 ALA 127 121 121 ALA ALA C . n 
C 1 128 VAL 128 122 122 VAL VAL C . n 
C 1 129 ALA 129 123 123 ALA ALA C . n 
C 1 130 ILE 130 124 124 ILE ILE C . n 
C 1 131 LEU 131 125 125 LEU LEU C . n 
C 1 132 ALA 132 126 126 ALA ALA C . n 
C 1 133 ALA 133 127 127 ALA ALA C . n 
C 1 134 GLY 134 128 128 GLY GLY C . n 
C 1 135 THR 135 129 129 THR THR C . n 
C 1 136 ASP 136 130 130 ASP ASP C . n 
C 1 137 PRO 137 131 131 PRO PRO C . n 
C 1 138 GLY 138 132 132 GLY GLY C . n 
C 1 139 THR 139 133 133 THR THR C . n 
C 1 140 CYS 140 134 134 CYS CYS C . n 
C 1 141 SER 141 135 135 SER SER C . n 
C 1 142 MET 142 136 136 MET MET C . n 
C 1 143 ILE 143 137 137 ILE ILE C . n 
C 1 144 ARG 144 138 138 ARG ARG C . n 
C 1 145 SER 145 139 139 SER SER C . n 
C 1 146 ILE 146 140 140 ILE ILE C . n 
C 1 147 LEU 147 141 141 LEU LEU C . n 
C 1 148 GLU 148 142 142 GLU GLU C . n 
C 1 149 PHE 149 143 143 PHE PHE C . n 
C 1 150 MET 150 144 144 MET MET C . n 
C 1 151 ALA 151 145 145 ALA ALA C . n 
C 1 152 PRO 152 146 146 PRO PRO C . n 
C 1 153 TYR 153 147 147 TYR TYR C . n 
C 1 154 GLY 154 148 148 GLY GLY C . n 
C 1 155 ILE 155 149 149 ILE ILE C . n 
C 1 156 THR 156 150 150 THR THR C . n 
C 1 157 TYR 157 151 151 TYR TYR C . n 
C 1 158 THR 158 152 152 THR THR C . n 
C 1 159 ASN 159 153 153 ASN ASN C . n 
C 1 160 VAL 160 154 154 VAL VAL C . n 
C 1 161 GLY 161 155 155 GLY GLY C . n 
C 1 162 PRO 162 156 156 PRO PRO C . n 
C 1 163 GLY 163 157 157 GLY GLY C . n 
C 1 164 MET 164 158 158 MET MET C . n 
C 1 165 SER 165 159 159 SER SER C . n 
C 1 166 MET 166 160 160 MET MET C . n 
C 1 167 GLY 167 161 161 GLY GLY C . n 
C 1 168 HIS 168 162 162 HIS HIS C . n 
C 1 169 SER 169 163 163 SER SER C . n 
C 1 170 VAL 170 164 164 VAL VAL C . n 
C 1 171 ALA 171 165 165 ALA ALA C . n 
C 1 172 VAL 172 166 166 VAL VAL C . n 
C 1 173 LYS 173 167 167 LYS LYS C . n 
C 1 174 ALA 174 168 168 ALA ALA C . n 
C 1 175 ILE 175 169 169 ILE ILE C . n 
C 1 176 GLU 176 170 170 GLU GLU C . n 
C 1 177 GLY 177 171 171 GLY GLY C . n 
C 1 178 VAL 178 172 172 VAL VAL C . n 
C 1 179 LYS 179 173 173 LYS LYS C . n 
C 1 180 ASP 180 174 174 ASP ASP C . n 
C 1 181 ALA 181 175 175 ALA ALA C . n 
C 1 182 LEU 182 176 176 LEU LEU C . n 
C 1 183 ALA 183 177 177 ALA ALA C . n 
C 1 184 LEU 184 178 178 LEU LEU C . n 
C 1 185 THR 185 179 179 THR THR C . n 
C 1 186 ILE 186 180 180 ILE ILE C . n 
C 1 187 PRO 187 181 181 PRO PRO C . n 
C 1 188 ILE 188 182 182 ILE ILE C . n 
C 1 189 GLY 189 183 183 GLY GLY C . n 
C 1 190 THR 190 184 184 THR THR C . n 
C 1 191 GLY 191 185 185 GLY GLY C . n 
C 1 192 LEU 192 186 186 LEU LEU C . n 
C 1 193 HIS 193 187 187 HIS HIS C . n 
C 1 194 ARG 194 188 188 ARG ARG C . n 
C 1 195 ARG 195 189 189 ARG ARG C . n 
C 1 196 MET 196 190 190 MET MET C . n 
C 1 197 VAL 197 191 191 VAL VAL C . n 
C 1 198 TYR 198 192 192 TYR TYR C . n 
C 1 199 VAL 199 193 193 VAL VAL C . n 
C 1 200 GLU 200 194 ?   ?   ?   C . n 
C 1 201 LEU 201 195 ?   ?   ?   C . n 
C 1 202 GLU 202 196 ?   ?   ?   C . n 
C 1 203 GLU 203 197 ?   ?   ?   C . n 
C 1 204 GLY 204 198 ?   ?   ?   C . n 
C 1 205 ALA 205 199 ?   ?   ?   C . n 
C 1 206 ASP 206 200 ?   ?   ?   C . n 
C 1 207 PHE 207 201 ?   ?   ?   C . n 
C 1 208 ALA 208 202 ?   ?   ?   C . n 
C 1 209 THR 209 203 ?   ?   ?   C . n 
C 1 210 VAL 210 204 ?   ?   ?   C . n 
C 1 211 LYS 211 205 ?   ?   ?   C . n 
C 1 212 GLU 212 206 ?   ?   ?   C . n 
C 1 213 ARG 213 207 ?   ?   ?   C . n 
C 1 214 ILE 214 208 ?   ?   ?   C . n 
C 1 215 LEU 215 209 ?   ?   ?   C . n 
C 1 216 GLN 216 210 ?   ?   ?   C . n 
C 1 217 ASP 217 211 ?   ?   ?   C . n 
C 1 218 PRO 218 212 ?   ?   ?   C . n 
C 1 219 TYR 219 213 ?   ?   ?   C . n 
C 1 220 PHE 220 214 214 PHE PHE C . n 
C 1 221 VAL 221 215 215 VAL VAL C . n 
C 1 222 HIS 222 216 216 HIS HIS C . n 
C 1 223 ASP 223 217 217 ASP ASP C . n 
C 1 224 GLU 224 218 218 GLU GLU C . n 
C 1 225 THR 225 219 219 THR THR C . n 
C 1 226 HIS 226 220 220 HIS HIS C . n 
C 1 227 VAL 227 221 221 VAL VAL C . n 
C 1 228 LEU 228 222 222 LEU LEU C . n 
C 1 229 GLN 229 223 223 GLN GLN C . n 
C 1 230 VAL 230 224 224 VAL VAL C . n 
C 1 231 ASP 231 225 225 ASP ASP C . n 
C 1 232 ASP 232 226 226 ASP ASP C . n 
C 1 233 VAL 233 227 227 VAL VAL C . n 
C 1 234 LYS 234 228 228 LYS LYS C . n 
C 1 235 GLN 235 229 229 GLN GLN C . n 
C 1 236 LEU 236 230 230 LEU LEU C . n 
C 1 237 ILE 237 231 231 ILE ILE C . n 
C 1 238 ASP 238 232 232 ASP ASP C . n 
C 1 239 ARG 239 233 233 ARG ARG C . n 
C 1 240 GLY 240 234 234 GLY GLY C . n 
C 1 241 ILE 241 235 235 ILE ILE C . n 
C 1 242 GLY 242 236 236 GLY GLY C . n 
C 1 243 VAL 243 237 237 VAL VAL C . n 
C 1 244 ARG 244 238 238 ARG ARG C . n 
C 1 245 MET 245 239 239 MET MET C . n 
C 1 246 GLU 246 240 240 GLU GLU C . n 
C 1 247 ARG 247 241 241 ARG ARG C . n 
C 1 248 LYS 248 242 242 LYS LYS C . n 
C 1 249 GLY 249 243 243 GLY GLY C . n 
C 1 250 VAL 250 244 244 VAL VAL C . n 
C 1 251 SER 251 245 245 SER SER C . n 
C 1 252 GLY 252 246 246 GLY GLY C . n 
C 1 253 GLN 253 247 247 GLN GLN C . n 
C 1 254 THR 254 248 248 THR THR C . n 
C 1 255 GLN 255 249 249 GLN GLN C . n 
C 1 256 ASN 256 250 250 ASN ASN C . n 
C 1 257 GLN 257 251 251 GLN GLN C . n 
C 1 258 LEU 258 252 252 LEU LEU C . n 
C 1 259 PHE 259 253 253 PHE PHE C . n 
C 1 260 THR 260 254 254 THR THR C . n 
C 1 261 TYR 261 255 255 TYR TYR C . n 
C 1 262 GLU 262 256 256 GLU GLU C . n 
C 1 263 MET 263 257 257 MET MET C . n 
C 1 264 ARG 264 258 258 ARG ARG C . n 
C 1 265 ILE 265 259 259 ILE ILE C . n 
C 1 266 ASN 266 260 260 ASN ASN C . n 
C 1 267 ASN 267 261 261 ASN ASN C . n 
C 1 268 PRO 268 262 262 PRO PRO C . n 
C 1 269 ALA 269 263 263 ALA ALA C . n 
C 1 270 LEU 270 264 264 LEU LEU C . n 
C 1 271 THR 271 265 265 THR THR C . n 
C 1 272 SER 272 266 266 SER SER C . n 
C 1 273 GLN 273 267 267 GLN GLN C . n 
C 1 274 VAL 274 268 268 VAL VAL C . n 
C 1 275 MET 275 269 269 MET MET C . n 
C 1 276 ILE 276 270 270 ILE ILE C . n 
C 1 277 ALA 277 271 271 ALA ALA C . n 
C 1 278 SER 278 272 272 SER SER C . n 
C 1 279 ALA 279 273 273 ALA ALA C . n 
C 1 280 ARG 280 274 274 ARG ARG C . n 
C 1 281 ALA 281 275 275 ALA ALA C . n 
C 1 282 ALA 282 276 276 ALA ALA C . n 
C 1 283 MET 283 277 277 MET MET C . n 
C 1 284 ARG 284 278 278 ARG ARG C . n 
C 1 285 GLN 285 279 279 GLN GLN C . n 
C 1 286 LYS 286 280 280 LYS LYS C . n 
C 1 287 PRO 287 281 281 PRO PRO C . n 
C 1 288 GLY 288 282 282 GLY GLY C . n 
C 1 289 ALA 289 283 283 ALA ALA C . n 
C 1 290 TYR 290 284 284 TYR TYR C . n 
C 1 291 THR 291 285 285 THR THR C . n 
C 1 292 MET 292 286 286 MET MET C . n 
C 1 293 ILE 293 287 287 ILE ILE C . n 
C 1 294 GLU 294 288 288 GLU GLU C . n 
C 1 295 ILE 295 289 289 ILE ILE C . n 
C 1 296 PRO 296 290 290 PRO PRO C . n 
C 1 297 ILE 297 291 291 ILE ILE C . n 
C 1 298 ILE 298 292 292 ILE ILE C . n 
C 1 299 ASP 299 293 293 ASP ASP C . n 
C 1 300 PHE 300 294 294 PHE PHE C . n 
C 1 301 LEU 301 295 295 LEU LEU C . n 
C 1 302 TYR 302 296 296 TYR TYR C . n 
C 1 303 GLY 303 297 297 GLY GLY C . n 
C 1 304 ASP 304 298 298 ASP ASP C . n 
C 1 305 ARG 305 299 299 ARG ARG C . n 
C 1 306 ASP 306 300 300 ASP ASP C . n 
C 1 307 GLU 307 301 301 GLU GLU C . n 
C 1 308 LEU 308 302 302 LEU LEU C . n 
C 1 309 ILE 309 303 303 ILE ILE C . n 
C 1 310 ARG 310 304 304 ARG ARG C . n 
C 1 311 ARG 311 305 305 ARG ARG C . n 
C 1 312 LEU 312 306 306 LEU LEU C . n 
C 1 313 VAL 313 307 307 VAL VAL C . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 2 NAP 1  401 401 NAP NAP A . 
E 2 NAP 1  401 401 NAP NAP B . 
F 2 NAP 1  401 401 NAP NAP C . 
G 3 HOH 1  501 21  HOH HOH A . 
G 3 HOH 2  502 15  HOH HOH A . 
G 3 HOH 3  503 11  HOH HOH A . 
G 3 HOH 4  504 31  HOH HOH A . 
G 3 HOH 5  505 13  HOH HOH A . 
G 3 HOH 6  506 30  HOH HOH A . 
G 3 HOH 7  507 17  HOH HOH A . 
G 3 HOH 8  508 24  HOH HOH A . 
H 3 HOH 1  501 2   HOH HOH B . 
H 3 HOH 2  502 29  HOH HOH B . 
H 3 HOH 3  503 10  HOH HOH B . 
H 3 HOH 4  504 16  HOH HOH B . 
H 3 HOH 5  505 12  HOH HOH B . 
H 3 HOH 6  506 28  HOH HOH B . 
H 3 HOH 7  507 22  HOH HOH B . 
I 3 HOH 1  501 5   HOH HOH C . 
I 3 HOH 2  502 9   HOH HOH C . 
I 3 HOH 3  503 7   HOH HOH C . 
I 3 HOH 4  504 26  HOH HOH C . 
I 3 HOH 5  505 23  HOH HOH C . 
I 3 HOH 6  506 1   HOH HOH C . 
I 3 HOH 7  507 6   HOH HOH C . 
I 3 HOH 8  508 20  HOH HOH C . 
I 3 HOH 9  509 18  HOH HOH C . 
I 3 HOH 10 510 4   HOH HOH C . 
I 3 HOH 11 511 3   HOH HOH C . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZMX 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     157.090 
_cell.length_a_esd                 ? 
_cell.length_b                     157.090 
_cell.length_b_esd                 ? 
_cell.length_c                     111.450 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZMX 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZMX 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.30 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          66.91 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'0.1 M Carboxylic acids; 0.1 M Imidazole-MES monohydrate (acid) pH 6.5; 20% v/v Ethylene glycol; 10% w/v PEG 8000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 S 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-10-14 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97918 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97918 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          64.57 
_reflns.entry_id                                       8ZMX 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.46 
_reflns.d_resolution_low                               49.81 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     51060 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.91 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                26.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.38 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.2187 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.46 
_reflns_shell.d_res_low                                     2.548 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             5017 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.39 
_reflns_shell.pdbx_CC_star                                  0.749 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  5.182 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZMX 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.46 
_refine.ls_d_res_low                             49.81 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     51032 
_refine.ls_number_reflns_R_free                  2560 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.93 
_refine.ls_percent_reflns_R_free                 5.02 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2275 
_refine.ls_R_factor_R_free                       0.2748 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2251 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      3WBB 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 30.73 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.42 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.46 
_refine_hist.d_res_low                        49.81 
_refine_hist.number_atoms_solvent             26 
_refine_hist.number_atoms_total               6776 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        6606 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         144 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.009  ? 6888 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.089  ? 9360 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 10.101 ? 1064 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.058  ? 1105 ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.011  ? 1206 ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.46 2.51  . . 143 2627 100.00 . . . . 0.3894 . . . . . . . . . . . 0.4130 
'X-RAY DIFFRACTION' 2.51 2.56  . . 141 2653 100.00 . . . . 0.3553 . . . . . . . . . . . 0.4276 
'X-RAY DIFFRACTION' 2.56 2.61  . . 146 2638 100.00 . . . . 0.3331 . . . . . . . . . . . 0.3442 
'X-RAY DIFFRACTION' 2.61 2.67  . . 150 2653 100.00 . . . . 0.3095 . . . . . . . . . . . 0.3824 
'X-RAY DIFFRACTION' 2.67 2.74  . . 136 2640 100.00 . . . . 0.2892 . . . . . . . . . . . 0.3572 
'X-RAY DIFFRACTION' 2.74 2.82  . . 133 2687 100.00 . . . . 0.2745 . . . . . . . . . . . 0.3875 
'X-RAY DIFFRACTION' 2.82 2.90  . . 153 2643 100.00 . . . . 0.2731 . . . . . . . . . . . 0.3477 
'X-RAY DIFFRACTION' 2.90 2.99  . . 139 2677 100.00 . . . . 0.2748 . . . . . . . . . . . 0.3068 
'X-RAY DIFFRACTION' 2.99 3.10  . . 146 2666 100.00 . . . . 0.2765 . . . . . . . . . . . 0.3405 
'X-RAY DIFFRACTION' 3.10 3.22  . . 143 2671 100.00 . . . . 0.2610 . . . . . . . . . . . 0.3223 
'X-RAY DIFFRACTION' 3.22 3.37  . . 145 2680 100.00 . . . . 0.2444 . . . . . . . . . . . 0.2787 
'X-RAY DIFFRACTION' 3.37 3.55  . . 124 2701 100.00 . . . . 0.2201 . . . . . . . . . . . 0.2890 
'X-RAY DIFFRACTION' 3.55 3.77  . . 131 2696 100.00 . . . . 0.2223 . . . . . . . . . . . 0.2502 
'X-RAY DIFFRACTION' 3.77 4.06  . . 155 2690 100.00 . . . . 0.2038 . . . . . . . . . . . 0.2807 
'X-RAY DIFFRACTION' 4.06 4.47  . . 129 2749 100.00 . . . . 0.1814 . . . . . . . . . . . 0.2106 
'X-RAY DIFFRACTION' 4.47 5.12  . . 164 2704 100.00 . . . . 0.1813 . . . . . . . . . . . 0.2315 
'X-RAY DIFFRACTION' 5.12 6.44  . . 150 2765 100.00 . . . . 0.2240 . . . . . . . . . . . 0.2725 
'X-RAY DIFFRACTION' 6.44 49.81 . . 132 2932 99.00  . . . . 0.2063 . . . . . . . . . . . 0.2411 
# 
_struct.entry_id                     8ZMX 
_struct.title                        'Crystal Structures of meso-diaminopimelate dehydrogenase from Bacillus thermozeamaize' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZMX 
_struct_keywords.text            'Complex, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
G N N 3 ? 
H N N 3 ? 
I N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A1Y3PXT7_9BACI 
_struct_ref.pdbx_db_accession          A0A1Y3PXT7 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SEIRTERPIRVAIIGYGNIGQYALQAVEEAPDMELAGVVRRQSSLEKPLPRELHGVSVVSDVSALGQVDVAVLCTPTRET
PAIAKELLARGIHTIDSFDIHQEIVQVRHELDEVARAHQAVAILAAGWDPGTDSMIRSILEFMAPYGITYTNFGPGMSMG
HSVAVKAIEGVKDALSLTIPIGTGLHRRMVYVELEEGADFATVKERILQDPYFVHDETHVLQVDDVKQLIDRGHGVRMER
KGVSGQTQNQLFTYEMRINNPALTSQVMIASARAAMRQKPGAYTMIEIPIIDFLYGDRDELIRRLV
;
_struct_ref.pdbx_align_begin           2 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZMX A 8 ? 313 ? A0A1Y3PXT7 2 ? 307 ? 2 307 
2 1 8ZMX B 8 ? 313 ? A0A1Y3PXT7 2 ? 307 ? 2 307 
3 1 8ZMX C 8 ? 313 ? A0A1Y3PXT7 2 ? 307 ? 2 307 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZMX MET A 1   ? UNP A0A1Y3PXT7 ?   ?   'initiating methionine' -5  1  
1 8ZMX HIS A 2   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        -4  2  
1 8ZMX HIS A 3   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        -3  3  
1 8ZMX HIS A 4   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        -2  4  
1 8ZMX HIS A 5   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        -1  5  
1 8ZMX HIS A 6   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        0   6  
1 8ZMX HIS A 7   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        1   7  
1 8ZMX THR A 135 ? UNP A0A1Y3PXT7 TRP 129 'engineered mutation'   129 8  
1 8ZMX CYS A 140 ? UNP A0A1Y3PXT7 ASP 134 'engineered mutation'   134 9  
1 8ZMX VAL A 160 ? UNP A0A1Y3PXT7 PHE 154 'engineered mutation'   154 10 
1 8ZMX ALA A 183 ? UNP A0A1Y3PXT7 SER 177 'engineered mutation'   177 11 
1 8ZMX ILE A 241 ? UNP A0A1Y3PXT7 HIS 235 'engineered mutation'   235 12 
2 8ZMX MET B 1   ? UNP A0A1Y3PXT7 ?   ?   'initiating methionine' -5  13 
2 8ZMX HIS B 2   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        -4  14 
2 8ZMX HIS B 3   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        -3  15 
2 8ZMX HIS B 4   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        -2  16 
2 8ZMX HIS B 5   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        -1  17 
2 8ZMX HIS B 6   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        0   18 
2 8ZMX HIS B 7   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        1   19 
2 8ZMX THR B 135 ? UNP A0A1Y3PXT7 TRP 129 'engineered mutation'   129 20 
2 8ZMX CYS B 140 ? UNP A0A1Y3PXT7 ASP 134 'engineered mutation'   134 21 
2 8ZMX VAL B 160 ? UNP A0A1Y3PXT7 PHE 154 'engineered mutation'   154 22 
2 8ZMX ALA B 183 ? UNP A0A1Y3PXT7 SER 177 'engineered mutation'   177 23 
2 8ZMX ILE B 241 ? UNP A0A1Y3PXT7 HIS 235 'engineered mutation'   235 24 
3 8ZMX MET C 1   ? UNP A0A1Y3PXT7 ?   ?   'initiating methionine' -5  25 
3 8ZMX HIS C 2   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        -4  26 
3 8ZMX HIS C 3   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        -3  27 
3 8ZMX HIS C 4   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        -2  28 
3 8ZMX HIS C 5   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        -1  29 
3 8ZMX HIS C 6   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        0   30 
3 8ZMX HIS C 7   ? UNP A0A1Y3PXT7 ?   ?   'expression tag'        1   31 
3 8ZMX THR C 135 ? UNP A0A1Y3PXT7 TRP 129 'engineered mutation'   129 32 
3 8ZMX CYS C 140 ? UNP A0A1Y3PXT7 ASP 134 'engineered mutation'   134 33 
3 8ZMX VAL C 160 ? UNP A0A1Y3PXT7 PHE 154 'engineered mutation'   154 34 
3 8ZMX ALA C 183 ? UNP A0A1Y3PXT7 SER 177 'engineered mutation'   177 35 
3 8ZMX ILE C 241 ? UNP A0A1Y3PXT7 HIS 235 'engineered mutation'   235 36 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA trimeric  3 
2 software_defined_assembly            PISA hexameric 6 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 7540  ? 
1 MORE         -17   ? 
1 'SSA (A^2)'  43490 ? 
2 'ABSA (A^2)' 33340 ? 
2 MORE         -127  ? 
2 'SSA (A^2)'  68730 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1   A,D,G       
1 2   B,E,H       
1 4   C,F,I       
2 1,4 A,C,D,F,G,I 
2 2,3 B,E,H       
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z               1.0000000000 0.0000000000  0.0000000000 0.0000000000   0.0000000000 
1.0000000000  0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000  0.0000000000   
2 'crystal symmetry operation' 3_444 -y-1/2,x-1/2,z-1/4  0.0000000000 -1.0000000000 0.0000000000 -78.5450000000 1.0000000000 
0.0000000000  0.0000000000 -78.5450000000 0.0000000000 0.0000000000 1.0000000000  -27.8625000000 
3 'crystal symmetry operation' 6_445 x-1/2,-y-1/2,-z+1/4 1.0000000000 0.0000000000  0.0000000000 -78.5450000000 0.0000000000 
-1.0000000000 0.0000000000 -78.5450000000 0.0000000000 0.0000000000 -1.0000000000 27.8625000000  
4 'crystal symmetry operation' 7_555 y,x,-z              0.0000000000 1.0000000000  0.0000000000 0.0000000000   1.0000000000 
0.0000000000  0.0000000000 0.0000000000   0.0000000000 0.0000000000 -1.0000000000 0.0000000000   
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 24  ? ALA A 37  ? GLY A 18  ALA A 31  1 ? 14 
HELX_P HELX_P2  AA2 ARG A 48  ? LYS A 54  ? ARG A 42  LYS A 48  1 ? 7  
HELX_P HELX_P3  AA3 PRO A 57  ? HIS A 61  ? PRO A 51  HIS A 55  5 ? 5  
HELX_P HELX_P4  AA4 ASP A 68  ? GLY A 73  ? ASP A 62  GLY A 67  5 ? 6  
HELX_P HELX_P5  AA5 PRO A 83  ? ARG A 85  ? PRO A 77  ARG A 79  5 ? 3  
HELX_P HELX_P6  AA6 GLU A 86  ? ARG A 97  ? GLU A 80  ARG A 91  1 ? 12 
HELX_P HELX_P7  AA7 ILE A 107 ? GLN A 109 ? ILE A 101 GLN A 103 5 ? 3  
HELX_P HELX_P8  AA8 GLU A 110 ? HIS A 125 ? GLU A 104 HIS A 119 1 ? 16 
HELX_P HELX_P9  AA9 GLY A 138 ? ALA A 151 ? GLY A 132 ALA A 145 1 ? 14 
HELX_P HELX_P10 AB1 SER A 165 ? ILE A 175 ? SER A 159 ILE A 169 1 ? 11 
HELX_P HELX_P11 AB2 ASP A 232 ? ILE A 237 ? ASP A 226 ILE A 231 5 ? 6  
HELX_P HELX_P12 AB3 ASN A 267 ? MET A 283 ? ASN A 261 MET A 277 1 ? 17 
HELX_P HELX_P13 AB4 THR A 291 ? ILE A 295 ? THR A 285 ILE A 289 5 ? 5  
HELX_P HELX_P14 AB5 PRO A 296 ? LEU A 301 ? PRO A 290 LEU A 295 5 ? 6  
HELX_P HELX_P15 AB6 ASP A 304 ? VAL A 313 ? ASP A 298 VAL A 307 1 ? 10 
HELX_P HELX_P16 AB7 GLY B 24  ? ALA B 37  ? GLY B 18  ALA B 31  1 ? 14 
HELX_P HELX_P17 AB8 ARG B 48  ? GLU B 53  ? ARG B 42  GLU B 47  1 ? 6  
HELX_P HELX_P18 AB9 PRO B 57  ? HIS B 61  ? PRO B 51  HIS B 55  5 ? 5  
HELX_P HELX_P19 AC1 ASP B 68  ? GLY B 73  ? ASP B 62  GLY B 67  5 ? 6  
HELX_P HELX_P20 AC2 PRO B 83  ? ARG B 85  ? PRO B 77  ARG B 79  5 ? 3  
HELX_P HELX_P21 AC3 GLU B 86  ? ALA B 96  ? GLU B 80  ALA B 90  1 ? 11 
HELX_P HELX_P22 AC4 ILE B 107 ? GLN B 109 ? ILE B 101 GLN B 103 5 ? 3  
HELX_P HELX_P23 AC5 GLU B 110 ? HIS B 125 ? GLU B 104 HIS B 119 1 ? 16 
HELX_P HELX_P24 AC6 GLY B 138 ? ALA B 151 ? GLY B 132 ALA B 145 1 ? 14 
HELX_P HELX_P25 AC7 MET B 166 ? ALA B 174 ? MET B 160 ALA B 168 1 ? 9  
HELX_P HELX_P26 AC8 ASP B 232 ? ILE B 237 ? ASP B 226 ILE B 231 5 ? 6  
HELX_P HELX_P27 AC9 ASN B 267 ? MET B 283 ? ASN B 261 MET B 277 1 ? 17 
HELX_P HELX_P28 AD1 THR B 291 ? ILE B 295 ? THR B 285 ILE B 289 5 ? 5  
HELX_P HELX_P29 AD2 PRO B 296 ? LEU B 301 ? PRO B 290 LEU B 295 5 ? 6  
HELX_P HELX_P30 AD3 ASP B 304 ? VAL B 313 ? ASP B 298 VAL B 307 1 ? 10 
HELX_P HELX_P31 AD4 GLY C 24  ? ALA C 37  ? GLY C 18  ALA C 31  1 ? 14 
HELX_P HELX_P32 AD5 ARG C 48  ? LYS C 54  ? ARG C 42  LYS C 48  1 ? 7  
HELX_P HELX_P33 AD6 ASP C 68  ? GLY C 73  ? ASP C 62  GLY C 67  5 ? 6  
HELX_P HELX_P34 AD7 GLU C 86  ? ALA C 96  ? GLU C 80  ALA C 90  1 ? 11 
HELX_P HELX_P35 AD8 ILE C 107 ? GLN C 109 ? ILE C 101 GLN C 103 5 ? 3  
HELX_P HELX_P36 AD9 GLU C 110 ? HIS C 125 ? GLU C 104 HIS C 119 1 ? 16 
HELX_P HELX_P37 AE1 GLY C 138 ? ALA C 151 ? GLY C 132 ALA C 145 1 ? 14 
HELX_P HELX_P38 AE2 SER C 165 ? LYS C 173 ? SER C 159 LYS C 167 1 ? 9  
HELX_P HELX_P39 AE3 ASP C 232 ? ILE C 237 ? ASP C 226 ILE C 231 5 ? 6  
HELX_P HELX_P40 AE4 ASN C 267 ? MET C 283 ? ASN C 261 MET C 277 1 ? 17 
HELX_P HELX_P41 AE5 THR C 291 ? ILE C 295 ? THR C 285 ILE C 289 5 ? 5  
HELX_P HELX_P42 AE6 PRO C 296 ? LEU C 301 ? PRO C 290 LEU C 295 5 ? 6  
HELX_P HELX_P43 AE7 ASP C 304 ? VAL C 313 ? ASP C 298 VAL C 307 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 6 ? 
AA3 ? 4 ? 
AA4 ? 7 ? 
AA5 ? 3 ? 
AA6 ? 4 ? 
AA7 ? 7 ? 
AA8 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? parallel      
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? parallel      
AA4 1 2 ? parallel      
AA4 2 3 ? parallel      
AA4 3 4 ? parallel      
AA4 4 5 ? parallel      
AA4 5 6 ? parallel      
AA4 6 7 ? parallel      
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? parallel      
AA7 1 2 ? parallel      
AA7 2 3 ? parallel      
AA7 3 4 ? parallel      
AA7 4 5 ? parallel      
AA7 5 6 ? parallel      
AA7 6 7 ? parallel      
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 65  ? VAL A 66  ? VAL A 59  VAL A 60  
AA1 2 MET A 40  ? VAL A 46  ? MET A 34  VAL A 40  
AA1 3 ILE A 16  ? ILE A 21  ? ILE A 10  ILE A 15  
AA1 4 VAL A 77  ? LEU A 80  ? VAL A 71  LEU A 74  
AA1 5 HIS A 100 ? ILE A 102 ? HIS A 94  ILE A 96  
AA1 6 VAL A 128 ? ILE A 130 ? VAL A 122 ILE A 124 
AA1 7 GLY A 288 ? TYR A 290 ? GLY A 282 TYR A 284 
AA2 1 TYR A 153 ? VAL A 160 ? TYR A 147 VAL A 154 
AA2 2 GLY A 240 ? SER A 251 ? GLY A 234 SER A 245 
AA2 3 THR A 254 ? ASN A 266 ? THR A 248 ASN A 260 
AA2 4 THR C 254 ? ASN C 266 ? THR C 248 ASN C 260 
AA2 5 GLY C 240 ? SER C 251 ? GLY C 234 SER C 245 
AA2 6 TYR C 153 ? GLY C 161 ? TYR C 147 GLY C 155 
AA3 1 GLY A 163 ? MET A 164 ? GLY A 157 MET A 158 
AA3 2 ASP A 180 ? PRO A 187 ? ASP A 174 PRO A 181 
AA3 3 HIS A 193 ? GLU A 200 ? HIS A 187 GLU A 194 
AA3 4 THR A 225 ? GLN A 229 ? THR A 219 GLN A 223 
AA4 1 VAL B 65  ? VAL B 66  ? VAL B 59  VAL B 60  
AA4 2 MET B 40  ? VAL B 46  ? MET B 34  VAL B 40  
AA4 3 ILE B 16  ? ILE B 21  ? ILE B 10  ILE B 15  
AA4 4 VAL B 77  ? LEU B 80  ? VAL B 71  LEU B 74  
AA4 5 HIS B 100 ? ILE B 102 ? HIS B 94  ILE B 96  
AA4 6 VAL B 128 ? ILE B 130 ? VAL B 122 ILE B 124 
AA4 7 GLY B 288 ? TYR B 290 ? GLY B 282 TYR B 284 
AA5 1 TYR B 153 ? VAL B 160 ? TYR B 147 VAL B 154 
AA5 2 GLY B 240 ? SER B 251 ? GLY B 234 SER B 245 
AA5 3 THR B 254 ? ASN B 266 ? THR B 248 ASN B 260 
AA6 1 GLY B 163 ? MET B 164 ? GLY B 157 MET B 158 
AA6 2 ALA B 181 ? GLY B 189 ? ALA B 175 GLY B 183 
AA6 3 LEU B 192 ? VAL B 199 ? LEU B 186 VAL B 193 
AA6 4 THR B 225 ? GLN B 229 ? THR B 219 GLN B 223 
AA7 1 VAL C 65  ? VAL C 66  ? VAL C 59  VAL C 60  
AA7 2 MET C 40  ? VAL C 46  ? MET C 34  VAL C 40  
AA7 3 ILE C 16  ? ILE C 21  ? ILE C 10  ILE C 15  
AA7 4 VAL C 77  ? LEU C 80  ? VAL C 71  LEU C 74  
AA7 5 HIS C 100 ? ILE C 102 ? HIS C 94  ILE C 96  
AA7 6 VAL C 128 ? ILE C 130 ? VAL C 122 ILE C 124 
AA7 7 GLY C 288 ? TYR C 290 ? GLY C 282 TYR C 284 
AA8 1 GLY C 163 ? MET C 164 ? GLY C 157 MET C 158 
AA8 2 LEU C 182 ? GLY C 189 ? LEU C 176 GLY C 183 
AA8 3 LEU C 192 ? TYR C 198 ? LEU C 186 TYR C 192 
AA8 4 THR C 225 ? LEU C 228 ? THR C 219 LEU C 222 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 66  ? O VAL A 60  N VAL A 45  ? N VAL A 39  
AA1 2 3 O ALA A 43  ? O ALA A 37  N VAL A 18  ? N VAL A 12  
AA1 3 4 N ALA A 19  ? N ALA A 13  O VAL A 79  ? O VAL A 73  
AA1 4 5 N LEU A 80  ? N LEU A 74  O ILE A 102 ? O ILE A 96  
AA1 5 6 N THR A 101 ? N THR A 95  O ILE A 130 ? O ILE A 124 
AA1 6 7 N ALA A 129 ? N ALA A 123 O TYR A 290 ? O TYR A 284 
AA2 1 2 N ASN A 159 ? N ASN A 153 O ARG A 244 ? O ARG A 238 
AA2 2 3 N MET A 245 ? N MET A 239 O TYR A 261 ? O TYR A 255 
AA2 3 4 N THR A 260 ? N THR A 254 O GLU C 262 ? O GLU C 256 
AA2 4 5 O GLN C 257 ? O GLN C 251 N GLY C 249 ? N GLY C 243 
AA2 5 6 O ARG C 244 ? O ARG C 238 N ASN C 159 ? N ASN C 153 
AA3 1 2 N GLY A 163 ? N GLY A 157 O THR A 185 ? O THR A 179 
AA3 2 3 N LEU A 182 ? N LEU A 176 O TYR A 198 ? O TYR A 192 
AA3 3 4 N VAL A 199 ? N VAL A 193 O LEU A 228 ? O LEU A 222 
AA4 1 2 O VAL B 66  ? O VAL B 60  N VAL B 45  ? N VAL B 39  
AA4 2 3 O ALA B 43  ? O ALA B 37  N VAL B 18  ? N VAL B 12  
AA4 3 4 N ILE B 21  ? N ILE B 15  O VAL B 79  ? O VAL B 73  
AA4 4 5 N LEU B 80  ? N LEU B 74  O ILE B 102 ? O ILE B 96  
AA4 5 6 N THR B 101 ? N THR B 95  O ILE B 130 ? O ILE B 124 
AA4 6 7 N ALA B 129 ? N ALA B 123 O TYR B 290 ? O TYR B 284 
AA5 1 2 N ASN B 159 ? N ASN B 153 O ARG B 244 ? O ARG B 238 
AA5 2 3 N MET B 245 ? N MET B 239 O TYR B 261 ? O TYR B 255 
AA6 1 2 N GLY B 163 ? N GLY B 157 O THR B 185 ? O THR B 179 
AA6 2 3 N GLY B 189 ? N GLY B 183 O LEU B 192 ? O LEU B 186 
AA6 3 4 N VAL B 197 ? N VAL B 191 O LEU B 228 ? O LEU B 222 
AA7 1 2 O VAL C 66  ? O VAL C 60  N VAL C 45  ? N VAL C 39  
AA7 2 3 O ALA C 43  ? O ALA C 37  N VAL C 18  ? N VAL C 12  
AA7 3 4 N ALA C 19  ? N ALA C 13  O VAL C 79  ? O VAL C 73  
AA7 4 5 N LEU C 80  ? N LEU C 74  O ILE C 102 ? O ILE C 96  
AA7 5 6 N THR C 101 ? N THR C 95  O ILE C 130 ? O ILE C 124 
AA7 6 7 N ALA C 129 ? N ALA C 123 O TYR C 290 ? O TYR C 284 
AA8 1 2 N GLY C 163 ? N GLY C 157 O THR C 185 ? O THR C 179 
AA8 2 3 N LEU C 182 ? N LEU C 176 O TYR C 198 ? O TYR C 192 
AA8 3 4 N VAL C 197 ? N VAL C 191 O HIS C 226 ? O HIS C 220 
# 
_pdbx_entry_details.entry_id                   8ZMX 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 GLU A 7   ? ? 116.25  -72.44  
2  1 TYR A 17  ? ? -102.57 69.63   
3  1 GLN A 68  ? ? 64.54   86.31   
4  1 PHE A 99  ? ? -33.09  125.83  
5  1 ALA A 127 ? ? -112.55 66.59   
6  1 THR A 129 ? ? -81.56  -74.66  
7  1 GLU A 206 ? ? 49.79   -80.27  
8  1 ILE A 208 ? ? -78.42  31.63   
9  1 GLN A 210 ? ? 24.00   -121.65 
10 1 ASP A 211 ? ? -155.79 72.03   
11 1 PRO A 212 ? ? -62.91  88.07   
12 1 TYR A 213 ? ? 53.13   -147.58 
13 1 PHE A 214 ? ? 65.69   -24.62  
14 1 TYR B 17  ? ? -104.66 77.37   
15 1 PHE B 99  ? ? -24.29  126.17  
16 1 ALA B 127 ? ? -103.43 66.49   
17 1 THR B 129 ? ? -102.07 -61.47  
18 1 ALA B 145 ? ? -150.17 83.26   
19 1 MET B 160 ? ? -136.50 -50.35  
20 1 ALA B 168 ? ? -77.51  -115.54 
21 1 ILE B 169 ? ? 33.21   -138.39 
22 1 GLU B 170 ? ? -79.06  -143.87 
23 1 THR B 184 ? ? 38.53   46.30   
24 1 LEU B 209 ? ? -149.43 11.65   
25 1 PHE C 99  ? ? -29.52  122.15  
26 1 ALA C 127 ? ? -103.60 75.43   
27 1 ASP C 174 ? ? 60.73   143.63  
28 1 VAL C 215 ? ? -147.61 -5.46   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -y+1/2,x+1/2,z+3/4  
3 y+1/2,-x+1/2,z+1/4  
4 x+1/2,-y+1/2,-z+1/4 
5 -x+1/2,y+1/2,-z+3/4 
6 -x,-y,z+1/2         
7 y,x,-z              
8 -y,-x,-z+1/2        
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       508 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.76 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -5  ? A MET 1   
2  1 Y 1 A HIS -4  ? A HIS 2   
3  1 Y 1 A HIS -3  ? A HIS 3   
4  1 Y 1 A HIS -2  ? A HIS 4   
5  1 Y 1 A HIS -1  ? A HIS 5   
6  1 Y 1 A HIS 0   ? A HIS 6   
7  1 Y 1 A HIS 1   ? A HIS 7   
8  1 Y 1 A SER 2   ? A SER 8   
9  1 Y 1 A GLU 3   ? A GLU 9   
10 1 Y 1 A ILE 4   ? A ILE 10  
11 1 Y 1 A ARG 5   ? A ARG 11  
12 1 Y 1 A GLU 196 ? A GLU 202 
13 1 Y 1 A GLU 197 ? A GLU 203 
14 1 Y 1 A GLY 198 ? A GLY 204 
15 1 Y 1 A ALA 199 ? A ALA 205 
16 1 Y 1 A ASP 200 ? A ASP 206 
17 1 Y 1 A PHE 201 ? A PHE 207 
18 1 Y 1 A ALA 202 ? A ALA 208 
19 1 Y 1 A THR 203 ? A THR 209 
20 1 Y 1 A VAL 204 ? A VAL 210 
21 1 Y 1 B MET -5  ? B MET 1   
22 1 Y 1 B HIS -4  ? B HIS 2   
23 1 Y 1 B HIS -3  ? B HIS 3   
24 1 Y 1 B HIS -2  ? B HIS 4   
25 1 Y 1 B HIS -1  ? B HIS 5   
26 1 Y 1 B HIS 0   ? B HIS 6   
27 1 Y 1 B HIS 1   ? B HIS 7   
28 1 Y 1 B SER 2   ? B SER 8   
29 1 Y 1 B GLU 3   ? B GLU 9   
30 1 Y 1 B ILE 4   ? B ILE 10  
31 1 Y 1 B ARG 5   ? B ARG 11  
32 1 Y 1 B LEU 195 ? B LEU 201 
33 1 Y 1 B GLU 196 ? B GLU 202 
34 1 Y 1 B GLU 197 ? B GLU 203 
35 1 Y 1 B GLY 198 ? B GLY 204 
36 1 Y 1 B ALA 199 ? B ALA 205 
37 1 Y 1 B ASP 200 ? B ASP 206 
38 1 Y 1 B PHE 201 ? B PHE 207 
39 1 Y 1 B ALA 202 ? B ALA 208 
40 1 Y 1 B THR 203 ? B THR 209 
41 1 Y 1 B VAL 204 ? B VAL 210 
42 1 Y 1 B LYS 205 ? B LYS 211 
43 1 Y 1 B PRO 212 ? B PRO 218 
44 1 Y 1 B TYR 213 ? B TYR 219 
45 1 Y 1 B PHE 214 ? B PHE 220 
46 1 Y 1 B VAL 215 ? B VAL 221 
47 1 Y 1 B HIS 216 ? B HIS 222 
48 1 Y 1 C MET -5  ? C MET 1   
49 1 Y 1 C HIS -4  ? C HIS 2   
50 1 Y 1 C HIS -3  ? C HIS 3   
51 1 Y 1 C HIS -2  ? C HIS 4   
52 1 Y 1 C HIS -1  ? C HIS 5   
53 1 Y 1 C HIS 0   ? C HIS 6   
54 1 Y 1 C HIS 1   ? C HIS 7   
55 1 Y 1 C SER 2   ? C SER 8   
56 1 Y 1 C GLU 3   ? C GLU 9   
57 1 Y 1 C ILE 4   ? C ILE 10  
58 1 Y 1 C ARG 52  ? C ARG 58  
59 1 Y 1 C GLU 53  ? C GLU 59  
60 1 Y 1 C LEU 54  ? C LEU 60  
61 1 Y 1 C HIS 55  ? C HIS 61  
62 1 Y 1 C GLU 194 ? C GLU 200 
63 1 Y 1 C LEU 195 ? C LEU 201 
64 1 Y 1 C GLU 196 ? C GLU 202 
65 1 Y 1 C GLU 197 ? C GLU 203 
66 1 Y 1 C GLY 198 ? C GLY 204 
67 1 Y 1 C ALA 199 ? C ALA 205 
68 1 Y 1 C ASP 200 ? C ASP 206 
69 1 Y 1 C PHE 201 ? C PHE 207 
70 1 Y 1 C ALA 202 ? C ALA 208 
71 1 Y 1 C THR 203 ? C THR 209 
72 1 Y 1 C VAL 204 ? C VAL 210 
73 1 Y 1 C LYS 205 ? C LYS 211 
74 1 Y 1 C GLU 206 ? C GLU 212 
75 1 Y 1 C ARG 207 ? C ARG 213 
76 1 Y 1 C ILE 208 ? C ILE 214 
77 1 Y 1 C LEU 209 ? C LEU 215 
78 1 Y 1 C GLN 210 ? C GLN 216 
79 1 Y 1 C ASP 211 ? C ASP 217 
80 1 Y 1 C PRO 212 ? C PRO 218 
81 1 Y 1 C TYR 213 ? C TYR 219 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
NAP PA   P N R 250 
NAP O1A  O N N 251 
NAP O2A  O N N 252 
NAP O5B  O N N 253 
NAP C5B  C N N 254 
NAP C4B  C N R 255 
NAP O4B  O N N 256 
NAP C3B  C N R 257 
NAP O3B  O N N 258 
NAP C2B  C N R 259 
NAP O2B  O N N 260 
NAP C1B  C N R 261 
NAP N9A  N Y N 262 
NAP C8A  C Y N 263 
NAP N7A  N Y N 264 
NAP C5A  C Y N 265 
NAP C6A  C Y N 266 
NAP N6A  N N N 267 
NAP N1A  N Y N 268 
NAP C2A  C Y N 269 
NAP N3A  N Y N 270 
NAP C4A  C Y N 271 
NAP O3   O N N 272 
NAP PN   P N N 273 
NAP O1N  O N N 274 
NAP O2N  O N N 275 
NAP O5D  O N N 276 
NAP C5D  C N N 277 
NAP C4D  C N R 278 
NAP O4D  O N N 279 
NAP C3D  C N S 280 
NAP O3D  O N N 281 
NAP C2D  C N R 282 
NAP O2D  O N N 283 
NAP C1D  C N R 284 
NAP N1N  N Y N 285 
NAP C2N  C Y N 286 
NAP C3N  C Y N 287 
NAP C7N  C N N 288 
NAP O7N  O N N 289 
NAP N7N  N N N 290 
NAP C4N  C Y N 291 
NAP C5N  C Y N 292 
NAP C6N  C Y N 293 
NAP P2B  P N N 294 
NAP O1X  O N N 295 
NAP O2X  O N N 296 
NAP O3X  O N N 297 
NAP HOA2 H N N 298 
NAP H51A H N N 299 
NAP H52A H N N 300 
NAP H4B  H N N 301 
NAP H3B  H N N 302 
NAP HO3A H N N 303 
NAP H2B  H N N 304 
NAP H1B  H N N 305 
NAP H8A  H N N 306 
NAP H61A H N N 307 
NAP H62A H N N 308 
NAP H2A  H N N 309 
NAP H51N H N N 310 
NAP H52N H N N 311 
NAP H4D  H N N 312 
NAP H3D  H N N 313 
NAP HO3N H N N 314 
NAP H2D  H N N 315 
NAP HO2N H N N 316 
NAP H1D  H N N 317 
NAP H2N  H N N 318 
NAP H71N H N N 319 
NAP H72N H N N 320 
NAP H4N  H N N 321 
NAP H5N  H N N 322 
NAP H6N  H N N 323 
NAP HOP2 H N N 324 
NAP HOP3 H N N 325 
PHE N    N N N 326 
PHE CA   C N S 327 
PHE C    C N N 328 
PHE O    O N N 329 
PHE CB   C N N 330 
PHE CG   C Y N 331 
PHE CD1  C Y N 332 
PHE CD2  C Y N 333 
PHE CE1  C Y N 334 
PHE CE2  C Y N 335 
PHE CZ   C Y N 336 
PHE OXT  O N N 337 
PHE H    H N N 338 
PHE H2   H N N 339 
PHE HA   H N N 340 
PHE HB2  H N N 341 
PHE HB3  H N N 342 
PHE HD1  H N N 343 
PHE HD2  H N N 344 
PHE HE1  H N N 345 
PHE HE2  H N N 346 
PHE HZ   H N N 347 
PHE HXT  H N N 348 
PRO N    N N N 349 
PRO CA   C N S 350 
PRO C    C N N 351 
PRO O    O N N 352 
PRO CB   C N N 353 
PRO CG   C N N 354 
PRO CD   C N N 355 
PRO OXT  O N N 356 
PRO H    H N N 357 
PRO HA   H N N 358 
PRO HB2  H N N 359 
PRO HB3  H N N 360 
PRO HG2  H N N 361 
PRO HG3  H N N 362 
PRO HD2  H N N 363 
PRO HD3  H N N 364 
PRO HXT  H N N 365 
SER N    N N N 366 
SER CA   C N S 367 
SER C    C N N 368 
SER O    O N N 369 
SER CB   C N N 370 
SER OG   O N N 371 
SER OXT  O N N 372 
SER H    H N N 373 
SER H2   H N N 374 
SER HA   H N N 375 
SER HB2  H N N 376 
SER HB3  H N N 377 
SER HG   H N N 378 
SER HXT  H N N 379 
THR N    N N N 380 
THR CA   C N S 381 
THR C    C N N 382 
THR O    O N N 383 
THR CB   C N R 384 
THR OG1  O N N 385 
THR CG2  C N N 386 
THR OXT  O N N 387 
THR H    H N N 388 
THR H2   H N N 389 
THR HA   H N N 390 
THR HB   H N N 391 
THR HG1  H N N 392 
THR HG21 H N N 393 
THR HG22 H N N 394 
THR HG23 H N N 395 
THR HXT  H N N 396 
TRP N    N N N 397 
TRP CA   C N S 398 
TRP C    C N N 399 
TRP O    O N N 400 
TRP CB   C N N 401 
TRP CG   C Y N 402 
TRP CD1  C Y N 403 
TRP CD2  C Y N 404 
TRP NE1  N Y N 405 
TRP CE2  C Y N 406 
TRP CE3  C Y N 407 
TRP CZ2  C Y N 408 
TRP CZ3  C Y N 409 
TRP CH2  C Y N 410 
TRP OXT  O N N 411 
TRP H    H N N 412 
TRP H2   H N N 413 
TRP HA   H N N 414 
TRP HB2  H N N 415 
TRP HB3  H N N 416 
TRP HD1  H N N 417 
TRP HE1  H N N 418 
TRP HE3  H N N 419 
TRP HZ2  H N N 420 
TRP HZ3  H N N 421 
TRP HH2  H N N 422 
TRP HXT  H N N 423 
TYR N    N N N 424 
TYR CA   C N S 425 
TYR C    C N N 426 
TYR O    O N N 427 
TYR CB   C N N 428 
TYR CG   C Y N 429 
TYR CD1  C Y N 430 
TYR CD2  C Y N 431 
TYR CE1  C Y N 432 
TYR CE2  C Y N 433 
TYR CZ   C Y N 434 
TYR OH   O N N 435 
TYR OXT  O N N 436 
TYR H    H N N 437 
TYR H2   H N N 438 
TYR HA   H N N 439 
TYR HB2  H N N 440 
TYR HB3  H N N 441 
TYR HD1  H N N 442 
TYR HD2  H N N 443 
TYR HE1  H N N 444 
TYR HE2  H N N 445 
TYR HH   H N N 446 
TYR HXT  H N N 447 
VAL N    N N N 448 
VAL CA   C N S 449 
VAL C    C N N 450 
VAL O    O N N 451 
VAL CB   C N N 452 
VAL CG1  C N N 453 
VAL CG2  C N N 454 
VAL OXT  O N N 455 
VAL H    H N N 456 
VAL H2   H N N 457 
VAL HA   H N N 458 
VAL HB   H N N 459 
VAL HG11 H N N 460 
VAL HG12 H N N 461 
VAL HG13 H N N 462 
VAL HG21 H N N 463 
VAL HG22 H N N 464 
VAL HG23 H N N 465 
VAL HXT  H N N 466 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
NAP PA  O1A  doub N N 237 
NAP PA  O2A  sing N N 238 
NAP PA  O5B  sing N N 239 
NAP PA  O3   sing N N 240 
NAP O2A HOA2 sing N N 241 
NAP O5B C5B  sing N N 242 
NAP C5B C4B  sing N N 243 
NAP C5B H51A sing N N 244 
NAP C5B H52A sing N N 245 
NAP C4B O4B  sing N N 246 
NAP C4B C3B  sing N N 247 
NAP C4B H4B  sing N N 248 
NAP O4B C1B  sing N N 249 
NAP C3B O3B  sing N N 250 
NAP C3B C2B  sing N N 251 
NAP C3B H3B  sing N N 252 
NAP O3B HO3A sing N N 253 
NAP C2B O2B  sing N N 254 
NAP C2B C1B  sing N N 255 
NAP C2B H2B  sing N N 256 
NAP O2B P2B  sing N N 257 
NAP C1B N9A  sing N N 258 
NAP C1B H1B  sing N N 259 
NAP N9A C8A  sing Y N 260 
NAP N9A C4A  sing Y N 261 
NAP C8A N7A  doub Y N 262 
NAP C8A H8A  sing N N 263 
NAP N7A C5A  sing Y N 264 
NAP C5A C6A  sing Y N 265 
NAP C5A C4A  doub Y N 266 
NAP C6A N6A  sing N N 267 
NAP C6A N1A  doub Y N 268 
NAP N6A H61A sing N N 269 
NAP N6A H62A sing N N 270 
NAP N1A C2A  sing Y N 271 
NAP C2A N3A  doub Y N 272 
NAP C2A H2A  sing N N 273 
NAP N3A C4A  sing Y N 274 
NAP O3  PN   sing N N 275 
NAP PN  O1N  doub N N 276 
NAP PN  O2N  sing N N 277 
NAP PN  O5D  sing N N 278 
NAP O5D C5D  sing N N 279 
NAP C5D C4D  sing N N 280 
NAP C5D H51N sing N N 281 
NAP C5D H52N sing N N 282 
NAP C4D O4D  sing N N 283 
NAP C4D C3D  sing N N 284 
NAP C4D H4D  sing N N 285 
NAP O4D C1D  sing N N 286 
NAP C3D O3D  sing N N 287 
NAP C3D C2D  sing N N 288 
NAP C3D H3D  sing N N 289 
NAP O3D HO3N sing N N 290 
NAP C2D O2D  sing N N 291 
NAP C2D C1D  sing N N 292 
NAP C2D H2D  sing N N 293 
NAP O2D HO2N sing N N 294 
NAP C1D N1N  sing N N 295 
NAP C1D H1D  sing N N 296 
NAP N1N C2N  sing Y N 297 
NAP N1N C6N  doub Y N 298 
NAP C2N C3N  doub Y N 299 
NAP C2N H2N  sing N N 300 
NAP C3N C7N  sing N N 301 
NAP C3N C4N  sing Y N 302 
NAP C7N O7N  doub N N 303 
NAP C7N N7N  sing N N 304 
NAP N7N H71N sing N N 305 
NAP N7N H72N sing N N 306 
NAP C4N C5N  doub Y N 307 
NAP C4N H4N  sing N N 308 
NAP C5N C6N  sing Y N 309 
NAP C5N H5N  sing N N 310 
NAP C6N H6N  sing N N 311 
NAP P2B O1X  doub N N 312 
NAP P2B O2X  sing N N 313 
NAP P2B O3X  sing N N 314 
NAP O2X HOP2 sing N N 315 
NAP O3X HOP3 sing N N 316 
PHE N   CA   sing N N 317 
PHE N   H    sing N N 318 
PHE N   H2   sing N N 319 
PHE CA  C    sing N N 320 
PHE CA  CB   sing N N 321 
PHE CA  HA   sing N N 322 
PHE C   O    doub N N 323 
PHE C   OXT  sing N N 324 
PHE CB  CG   sing N N 325 
PHE CB  HB2  sing N N 326 
PHE CB  HB3  sing N N 327 
PHE CG  CD1  doub Y N 328 
PHE CG  CD2  sing Y N 329 
PHE CD1 CE1  sing Y N 330 
PHE CD1 HD1  sing N N 331 
PHE CD2 CE2  doub Y N 332 
PHE CD2 HD2  sing N N 333 
PHE CE1 CZ   doub Y N 334 
PHE CE1 HE1  sing N N 335 
PHE CE2 CZ   sing Y N 336 
PHE CE2 HE2  sing N N 337 
PHE CZ  HZ   sing N N 338 
PHE OXT HXT  sing N N 339 
PRO N   CA   sing N N 340 
PRO N   CD   sing N N 341 
PRO N   H    sing N N 342 
PRO CA  C    sing N N 343 
PRO CA  CB   sing N N 344 
PRO CA  HA   sing N N 345 
PRO C   O    doub N N 346 
PRO C   OXT  sing N N 347 
PRO CB  CG   sing N N 348 
PRO CB  HB2  sing N N 349 
PRO CB  HB3  sing N N 350 
PRO CG  CD   sing N N 351 
PRO CG  HG2  sing N N 352 
PRO CG  HG3  sing N N 353 
PRO CD  HD2  sing N N 354 
PRO CD  HD3  sing N N 355 
PRO OXT HXT  sing N N 356 
SER N   CA   sing N N 357 
SER N   H    sing N N 358 
SER N   H2   sing N N 359 
SER CA  C    sing N N 360 
SER CA  CB   sing N N 361 
SER CA  HA   sing N N 362 
SER C   O    doub N N 363 
SER C   OXT  sing N N 364 
SER CB  OG   sing N N 365 
SER CB  HB2  sing N N 366 
SER CB  HB3  sing N N 367 
SER OG  HG   sing N N 368 
SER OXT HXT  sing N N 369 
THR N   CA   sing N N 370 
THR N   H    sing N N 371 
THR N   H2   sing N N 372 
THR CA  C    sing N N 373 
THR CA  CB   sing N N 374 
THR CA  HA   sing N N 375 
THR C   O    doub N N 376 
THR C   OXT  sing N N 377 
THR CB  OG1  sing N N 378 
THR CB  CG2  sing N N 379 
THR CB  HB   sing N N 380 
THR OG1 HG1  sing N N 381 
THR CG2 HG21 sing N N 382 
THR CG2 HG22 sing N N 383 
THR CG2 HG23 sing N N 384 
THR OXT HXT  sing N N 385 
TRP N   CA   sing N N 386 
TRP N   H    sing N N 387 
TRP N   H2   sing N N 388 
TRP CA  C    sing N N 389 
TRP CA  CB   sing N N 390 
TRP CA  HA   sing N N 391 
TRP C   O    doub N N 392 
TRP C   OXT  sing N N 393 
TRP CB  CG   sing N N 394 
TRP CB  HB2  sing N N 395 
TRP CB  HB3  sing N N 396 
TRP CG  CD1  doub Y N 397 
TRP CG  CD2  sing Y N 398 
TRP CD1 NE1  sing Y N 399 
TRP CD1 HD1  sing N N 400 
TRP CD2 CE2  doub Y N 401 
TRP CD2 CE3  sing Y N 402 
TRP NE1 CE2  sing Y N 403 
TRP NE1 HE1  sing N N 404 
TRP CE2 CZ2  sing Y N 405 
TRP CE3 CZ3  doub Y N 406 
TRP CE3 HE3  sing N N 407 
TRP CZ2 CH2  doub Y N 408 
TRP CZ2 HZ2  sing N N 409 
TRP CZ3 CH2  sing Y N 410 
TRP CZ3 HZ3  sing N N 411 
TRP CH2 HH2  sing N N 412 
TRP OXT HXT  sing N N 413 
TYR N   CA   sing N N 414 
TYR N   H    sing N N 415 
TYR N   H2   sing N N 416 
TYR CA  C    sing N N 417 
TYR CA  CB   sing N N 418 
TYR CA  HA   sing N N 419 
TYR C   O    doub N N 420 
TYR C   OXT  sing N N 421 
TYR CB  CG   sing N N 422 
TYR CB  HB2  sing N N 423 
TYR CB  HB3  sing N N 424 
TYR CG  CD1  doub Y N 425 
TYR CG  CD2  sing Y N 426 
TYR CD1 CE1  sing Y N 427 
TYR CD1 HD1  sing N N 428 
TYR CD2 CE2  doub Y N 429 
TYR CD2 HD2  sing N N 430 
TYR CE1 CZ   doub Y N 431 
TYR CE1 HE1  sing N N 432 
TYR CE2 CZ   sing Y N 433 
TYR CE2 HE2  sing N N 434 
TYR CZ  OH   sing N N 435 
TYR OH  HH   sing N N 436 
TYR OXT HXT  sing N N 437 
VAL N   CA   sing N N 438 
VAL N   H    sing N N 439 
VAL N   H2   sing N N 440 
VAL CA  C    sing N N 441 
VAL CA  CB   sing N N 442 
VAL CA  HA   sing N N 443 
VAL C   O    doub N N 444 
VAL C   OXT  sing N N 445 
VAL CB  CG1  sing N N 446 
VAL CB  CG2  sing N N 447 
VAL CB  HB   sing N N 448 
VAL CG1 HG11 sing N N 449 
VAL CG1 HG12 sing N N 450 
VAL CG1 HG13 sing N N 451 
VAL CG2 HG21 sing N N 452 
VAL CG2 HG22 sing N N 453 
VAL CG2 HG23 sing N N 454 
VAL OXT HXT  sing N N 455 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           32071475 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3WBB 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 43 21 2' 
_space_group.name_Hall        'P 4nw 2abw' 
_space_group.IT_number        96 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8ZMX 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.006366 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.006366 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008973 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C   ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N   ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O   ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O1- ? ? 5.12366 3.84317 ? ? 3.49406  27.47979 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P   ? ? 9.51135 5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S   ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . THR A 1 12  ? 3.476   -0.495  23.989  1.00 76.96  ?  6   THR A N   1 
ATOM   2    C CA  . THR A 1 12  ? 3.514   -1.611  24.927  1.00 73.09  ?  6   THR A CA  1 
ATOM   3    C C   . THR A 1 12  ? 4.704   -1.545  25.918  1.00 76.22  ?  6   THR A C   1 
ATOM   4    O O   . THR A 1 12  ? 4.835   -2.437  26.761  1.00 85.50  ?  6   THR A O   1 
ATOM   5    C CB  . THR A 1 12  ? 3.548   -2.960  24.162  1.00 67.90  ?  6   THR A CB  1 
ATOM   6    O OG1 . THR A 1 12  ? 3.014   -3.997  24.992  1.00 77.85  ?  6   THR A OG1 1 
ATOM   7    C CG2 . THR A 1 12  ? 4.971   -3.333  23.730  1.00 59.09  ?  6   THR A CG2 1 
ATOM   8    N N   . GLU A 1 13  ? 5.538   -0.498  25.799  1.00 58.72  ?  7   GLU A N   1 
ATOM   9    C CA  . GLU A 1 13  ? 6.652   -0.117  26.694  1.00 71.48  ?  7   GLU A CA  1 
ATOM   10   C C   . GLU A 1 13  ? 7.983   -0.200  25.957  1.00 71.11  ?  7   GLU A C   1 
ATOM   11   O O   . GLU A 1 13  ? 8.579   0.837   25.650  1.00 71.25  ?  7   GLU A O   1 
ATOM   12   C CB  . GLU A 1 13  ? 6.774   -0.931  28.003  1.00 64.51  ?  7   GLU A CB  1 
ATOM   13   C CG  . GLU A 1 13  ? 7.427   -0.095  29.148  1.00 63.42  ?  7   GLU A CG  1 
ATOM   14   C CD  . GLU A 1 13  ? 8.462   -0.851  30.036  1.00 69.04  ?  7   GLU A CD  1 
ATOM   15   O OE1 . GLU A 1 13  ? 8.534   -2.101  29.977  1.00 72.70  ?  7   GLU A OE1 1 
ATOM   16   O OE2 . GLU A 1 13  ? 9.222   -0.188  30.802  1.00 60.64  -1 7   GLU A OE2 1 
ATOM   17   N N   . ARG A 1 14  ? 8.467   -1.410  25.681  1.00 62.77  ?  8   ARG A N   1 
ATOM   18   C CA  . ARG A 1 14  ? 9.608   -1.604  24.790  1.00 63.82  ?  8   ARG A CA  1 
ATOM   19   C C   . ARG A 1 14  ? 9.174   -2.588  23.715  1.00 62.08  ?  8   ARG A C   1 
ATOM   20   O O   . ARG A 1 14  ? 9.254   -3.807  23.924  1.00 61.57  ?  8   ARG A O   1 
ATOM   21   C CB  . ARG A 1 14  ? 10.849  -2.116  25.526  1.00 64.55  ?  8   ARG A CB  1 
ATOM   22   C CG  . ARG A 1 14  ? 11.145  -1.416  26.840  1.00 62.79  ?  8   ARG A CG  1 
ATOM   23   C CD  . ARG A 1 14  ? 12.509  -0.729  26.877  1.00 63.94  ?  8   ARG A CD  1 
ATOM   24   N NE  . ARG A 1 14  ? 12.548  0.204   27.998  1.00 65.29  ?  8   ARG A NE  1 
ATOM   25   C CZ  . ARG A 1 14  ? 13.484  0.240   28.941  1.00 67.95  ?  8   ARG A CZ  1 
ATOM   26   N NH1 . ARG A 1 14  ? 14.579  -0.535  28.881  1.00 55.19  ?  8   ARG A NH1 1 
ATOM   27   N NH2 . ARG A 1 14  ? 13.317  1.071   29.976  1.00 54.71  ?  8   ARG A NH2 1 
ATOM   28   N N   . PRO A 1 15  ? 8.728   -2.113  22.556  1.00 67.18  ?  9   PRO A N   1 
ATOM   29   C CA  . PRO A 1 15  ? 8.184   -3.027  21.538  1.00 61.98  ?  9   PRO A CA  1 
ATOM   30   C C   . PRO A 1 15  ? 9.195   -4.055  21.045  1.00 59.83  ?  9   PRO A C   1 
ATOM   31   O O   . PRO A 1 15  ? 10.406  -3.901  21.187  1.00 57.27  ?  9   PRO A O   1 
ATOM   32   C CB  . PRO A 1 15  ? 7.759   -2.085  20.404  1.00 59.48  ?  9   PRO A CB  1 
ATOM   33   C CG  . PRO A 1 15  ? 8.470   -0.784  20.689  1.00 58.59  ?  9   PRO A CG  1 
ATOM   34   C CD  . PRO A 1 15  ? 8.611   -0.700  22.165  1.00 59.34  ?  9   PRO A CD  1 
ATOM   35   N N   . ILE A 1 16  ? 8.665   -5.125  20.447  1.00 63.24  ?  10  ILE A N   1 
ATOM   36   C CA  . ILE A 1 16  ? 9.495   -6.156  19.828  1.00 59.38  ?  10  ILE A CA  1 
ATOM   37   C C   . ILE A 1 16  ? 10.048  -5.617  18.508  1.00 62.90  ?  10  ILE A C   1 
ATOM   38   O O   . ILE A 1 16  ? 9.286   -5.174  17.634  1.00 61.96  ?  10  ILE A O   1 
ATOM   39   C CB  . ILE A 1 16  ? 8.683   -7.443  19.624  1.00 59.66  ?  10  ILE A CB  1 
ATOM   40   C CG1 . ILE A 1 16  ? 8.086   -7.901  20.950  1.00 60.34  ?  10  ILE A CG1 1 
ATOM   41   C CG2 . ILE A 1 16  ? 9.529   -8.578  19.080  1.00 51.63  ?  10  ILE A CG2 1 
ATOM   42   C CD1 . ILE A 1 16  ? 6.957   -8.848  20.782  1.00 52.74  ?  10  ILE A CD1 1 
ATOM   43   N N   . ARG A 1 17  ? 11.382  -5.625  18.362  1.00 57.32  ?  11  ARG A N   1 
ATOM   44   C CA  . ARG A 1 17  ? 12.025  -5.158  17.131  1.00 56.90  ?  11  ARG A CA  1 
ATOM   45   C C   . ARG A 1 17  ? 12.137  -6.310  16.140  1.00 57.81  ?  11  ARG A C   1 
ATOM   46   O O   . ARG A 1 17  ? 12.849  -7.298  16.390  1.00 56.18  ?  11  ARG A O   1 
ATOM   47   C CB  . ARG A 1 17  ? 13.409  -4.567  17.396  1.00 62.83  ?  11  ARG A CB  1 
ATOM   48   C CG  . ARG A 1 17  ? 13.486  -3.605  18.561  1.00 66.75  ?  11  ARG A CG  1 
ATOM   49   C CD  . ARG A 1 17  ? 14.707  -2.729  18.432  1.00 67.86  ?  11  ARG A CD  1 
ATOM   50   N NE  . ARG A 1 17  ? 14.464  -1.654  17.479  1.00 69.94  ?  11  ARG A NE  1 
ATOM   51   C CZ  . ARG A 1 17  ? 15.158  -1.466  16.367  1.00 65.37  ?  11  ARG A CZ  1 
ATOM   52   N NH1 . ARG A 1 17  ? 16.223  -2.207  16.079  1.00 68.90  ?  11  ARG A NH1 1 
ATOM   53   N NH2 . ARG A 1 17  ? 14.766  -0.525  15.513  1.00 68.11  ?  11  ARG A NH2 1 
ATOM   54   N N   . VAL A 1 18  ? 11.455  -6.175  15.009  1.00 53.84  ?  12  VAL A N   1 
ATOM   55   C CA  . VAL A 1 18  ? 11.310  -7.261  14.042  1.00 53.92  ?  12  VAL A CA  1 
ATOM   56   C C   . VAL A 1 18  ? 12.024  -6.865  12.766  1.00 53.04  ?  12  VAL A C   1 
ATOM   57   O O   . VAL A 1 18  ? 11.908  -5.722  12.304  1.00 58.67  ?  12  VAL A O   1 
ATOM   58   C CB  . VAL A 1 18  ? 9.825   -7.582  13.753  1.00 52.04  ?  12  VAL A CB  1 
ATOM   59   C CG1 . VAL A 1 18  ? 9.702   -8.570  12.607  1.00 48.60  ?  12  VAL A CG1 1 
ATOM   60   C CG2 . VAL A 1 18  ? 9.144   -8.114  14.995  1.00 49.46  ?  12  VAL A CG2 1 
ATOM   61   N N   . ALA A 1 19  ? 12.783  -7.800  12.218  1.00 50.96  ?  13  ALA A N   1 
ATOM   62   C CA  . ALA A 1 19  ? 13.458  -7.642  10.941  1.00 56.86  ?  13  ALA A CA  1 
ATOM   63   C C   . ALA A 1 19  ? 12.803  -8.562  9.918   1.00 56.99  ?  13  ALA A C   1 
ATOM   64   O O   . ALA A 1 19  ? 12.513  -9.722  10.215  1.00 57.22  ?  13  ALA A O   1 
ATOM   65   C CB  . ALA A 1 19  ? 14.956  -7.973  11.067  1.00 52.87  ?  13  ALA A CB  1 
ATOM   66   N N   . ILE A 1 20  ? 12.570  -8.056  8.714   1.00 55.70  ?  14  ILE A N   1 
ATOM   67   C CA  . ILE A 1 20  ? 12.020  -8.862  7.632   1.00 58.23  ?  14  ILE A CA  1 
ATOM   68   C C   . ILE A 1 20  ? 13.160  -9.294  6.711   1.00 57.25  ?  14  ILE A C   1 
ATOM   69   O O   . ILE A 1 20  ? 13.928  -8.454  6.231   1.00 62.27  ?  14  ILE A O   1 
ATOM   70   C CB  . ILE A 1 20  ? 10.926  -8.087  6.876   1.00 53.84  ?  14  ILE A CB  1 
ATOM   71   C CG1 . ILE A 1 20  ? 9.678   -8.009  7.746   1.00 51.58  ?  14  ILE A CG1 1 
ATOM   72   C CG2 . ILE A 1 20  ? 10.549  -8.780  5.583   1.00 57.00  ?  14  ILE A CG2 1 
ATOM   73   C CD1 . ILE A 1 20  ? 8.740   -6.877  7.363   1.00 55.50  ?  14  ILE A CD1 1 
ATOM   74   N N   . ILE A 1 21  ? 13.274  -10.594 6.462   1.00 52.59  ?  15  ILE A N   1 
ATOM   75   C CA  . ILE A 1 21  ? 14.379  -11.161 5.690   1.00 56.89  ?  15  ILE A CA  1 
ATOM   76   C C   . ILE A 1 21  ? 13.851  -11.616 4.336   1.00 58.80  ?  15  ILE A C   1 
ATOM   77   O O   . ILE A 1 21  ? 13.174  -12.646 4.237   1.00 58.88  ?  15  ILE A O   1 
ATOM   78   C CB  . ILE A 1 21  ? 15.054  -12.328 6.419   1.00 56.13  ?  15  ILE A CB  1 
ATOM   79   C CG1 . ILE A 1 21  ? 15.366  -11.955 7.871   1.00 55.56  ?  15  ILE A CG1 1 
ATOM   80   C CG2 . ILE A 1 21  ? 16.267  -12.790 5.645   1.00 52.25  ?  15  ILE A CG2 1 
ATOM   81   C CD1 . ILE A 1 21  ? 16.441  -10.946 7.996   1.00 53.17  ?  15  ILE A CD1 1 
ATOM   82   N N   . GLY A 1 22  ? 14.184  -10.875 3.281   1.00 62.23  ?  16  GLY A N   1 
ATOM   83   C CA  . GLY A 1 22  ? 13.647  -11.178 1.968   1.00 62.81  ?  16  GLY A CA  1 
ATOM   84   C C   . GLY A 1 22  ? 12.392  -10.385 1.688   1.00 63.04  ?  16  GLY A C   1 
ATOM   85   O O   . GLY A 1 22  ? 11.355  -10.586 2.330   1.00 65.66  ?  16  GLY A O   1 
ATOM   86   N N   . TYR A 1 23  ? 12.486  -9.464  0.739   1.00 63.18  ?  17  TYR A N   1 
ATOM   87   C CA  . TYR A 1 23  ? 11.377  -8.589  0.391   1.00 60.92  ?  17  TYR A CA  1 
ATOM   88   C C   . TYR A 1 23  ? 10.718  -9.072  -0.902  1.00 65.36  ?  17  TYR A C   1 
ATOM   89   O O   . TYR A 1 23  ? 10.819  -8.451  -1.960  1.00 74.45  ?  17  TYR A O   1 
ATOM   90   C CB  . TYR A 1 23  ? 11.866  -7.153  0.273   1.00 56.93  ?  17  TYR A CB  1 
ATOM   91   C CG  . TYR A 1 23  ? 10.752  -6.148  0.403   1.00 64.88  ?  17  TYR A CG  1 
ATOM   92   C CD1 . TYR A 1 23  ? 10.076  -5.986  1.601   1.00 60.37  ?  17  TYR A CD1 1 
ATOM   93   C CD2 . TYR A 1 23  ? 10.347  -5.381  -0.690  1.00 68.30  ?  17  TYR A CD2 1 
ATOM   94   C CE1 . TYR A 1 23  ? 9.041   -5.096  1.715   1.00 62.74  ?  17  TYR A CE1 1 
ATOM   95   C CE2 . TYR A 1 23  ? 9.307   -4.471  -0.582  1.00 61.36  ?  17  TYR A CE2 1 
ATOM   96   C CZ  . TYR A 1 23  ? 8.666   -4.341  0.623   1.00 63.59  ?  17  TYR A CZ  1 
ATOM   97   O OH  . TYR A 1 23  ? 7.647   -3.448  0.757   1.00 67.24  ?  17  TYR A OH  1 
ATOM   98   N N   . GLY A 1 24  ? 10.050  -10.214 -0.799  1.00 64.25  ?  18  GLY A N   1 
ATOM   99   C CA  . GLY A 1 24  ? 9.193   -10.772 -1.841  1.00 65.34  ?  18  GLY A CA  1 
ATOM   100  C C   . GLY A 1 24  ? 7.720   -10.575 -1.527  1.00 67.86  ?  18  GLY A C   1 
ATOM   101  O O   . GLY A 1 24  ? 7.335   -9.642  -0.807  1.00 61.58  ?  18  GLY A O   1 
ATOM   102  N N   . ASN A 1 25  ? 6.875   -11.464 -2.067  1.00 62.15  ?  19  ASN A N   1 
ATOM   103  C CA  . ASN A 1 25  ? 5.447   -11.350 -1.782  1.00 65.46  ?  19  ASN A CA  1 
ATOM   104  C C   . ASN A 1 25  ? 5.183   -11.300 -0.285  1.00 64.31  ?  19  ASN A C   1 
ATOM   105  O O   . ASN A 1 25  ? 4.546   -10.373 0.221   1.00 64.19  ?  19  ASN A O   1 
ATOM   106  C CB  . ASN A 1 25  ? 4.675   -12.517 -2.389  1.00 73.31  ?  19  ASN A CB  1 
ATOM   107  C CG  . ASN A 1 25  ? 4.036   -12.170 -3.684  1.00 79.37  ?  19  ASN A CG  1 
ATOM   108  O OD1 . ASN A 1 25  ? 4.190   -12.894 -4.662  1.00 90.86  ?  19  ASN A OD1 1 
ATOM   109  N ND2 . ASN A 1 25  ? 3.326   -11.038 -3.720  1.00 81.49  ?  19  ASN A ND2 1 
ATOM   110  N N   . ILE A 1 26  ? 5.683   -12.302 0.440   1.00 62.58  ?  20  ILE A N   1 
ATOM   111  C CA  . ILE A 1 26  ? 5.427   -12.397 1.869   1.00 56.14  ?  20  ILE A CA  1 
ATOM   112  C C   . ILE A 1 26  ? 6.057   -11.245 2.644   1.00 61.38  ?  20  ILE A C   1 
ATOM   113  O O   . ILE A 1 26  ? 5.491   -10.782 3.643   1.00 59.70  ?  20  ILE A O   1 
ATOM   114  C CB  . ILE A 1 26  ? 5.898   -13.772 2.365   1.00 58.25  ?  20  ILE A CB  1 
ATOM   115  C CG1 . ILE A 1 26  ? 5.256   -14.861 1.495   1.00 61.34  ?  20  ILE A CG1 1 
ATOM   116  C CG2 . ILE A 1 26  ? 5.622   -13.944 3.846   1.00 58.07  ?  20  ILE A CG2 1 
ATOM   117  C CD1 . ILE A 1 26  ? 3.798   -15.141 1.840   1.00 58.79  ?  20  ILE A CD1 1 
ATOM   118  N N   . GLY A 1 27  ? 7.219   -10.758 2.209   1.00 59.58  ?  21  GLY A N   1 
ATOM   119  C CA  . GLY A 1 27  ? 7.838   -9.647  2.912   1.00 60.60  ?  21  GLY A CA  1 
ATOM   120  C C   . GLY A 1 27  ? 7.050   -8.352  2.797   1.00 60.35  ?  21  GLY A C   1 
ATOM   121  O O   . GLY A 1 27  ? 7.004   -7.556  3.742   1.00 57.04  ?  21  GLY A O   1 
ATOM   122  N N   . GLN A 1 28  ? 6.426   -8.110  1.642   1.00 57.98  ?  22  GLN A N   1 
ATOM   123  C CA  . GLN A 1 28  ? 5.624   -6.897  1.539   1.00 59.03  ?  22  GLN A CA  1 
ATOM   124  C C   . GLN A 1 28  ? 4.406   -6.976  2.440   1.00 56.96  ?  22  GLN A C   1 
ATOM   125  O O   . GLN A 1 28  ? 4.071   -6.001  3.119   1.00 56.77  ?  22  GLN A O   1 
ATOM   126  C CB  . GLN A 1 28  ? 5.212   -6.633  0.100   1.00 62.99  ?  22  GLN A CB  1 
ATOM   127  C CG  . GLN A 1 28  ? 6.337   -6.832  -0.888  1.00 70.97  ?  22  GLN A CG  1 
ATOM   128  C CD  . GLN A 1 28  ? 5.841   -6.931  -2.317  1.00 75.36  ?  22  GLN A CD  1 
ATOM   129  O OE1 . GLN A 1 28  ? 4.631   -6.969  -2.577  1.00 79.35  ?  22  GLN A OE1 1 
ATOM   130  N NE2 . GLN A 1 28  ? 6.776   -7.045  -3.247  1.00 74.91  ?  22  GLN A NE2 1 
ATOM   131  N N   . TYR A 1 29  ? 3.754   -8.136  2.500   1.00 56.85  ?  23  TYR A N   1 
ATOM   132  C CA  . TYR A 1 29  ? 2.612   -8.254  3.396   1.00 53.58  ?  23  TYR A CA  1 
ATOM   133  C C   . TYR A 1 29  ? 3.042   -8.226  4.857   1.00 52.85  ?  23  TYR A C   1 
ATOM   134  O O   . TYR A 1 29  ? 2.398   -7.554  5.682   1.00 49.25  ?  23  TYR A O   1 
ATOM   135  C CB  . TYR A 1 29  ? 1.820   -9.512  3.061   1.00 51.61  ?  23  TYR A CB  1 
ATOM   136  C CG  . TYR A 1 29  ? 0.957   -9.273  1.855   1.00 57.25  ?  23  TYR A CG  1 
ATOM   137  C CD1 . TYR A 1 29  ? -0.275  -8.608  1.976   1.00 53.49  ?  23  TYR A CD1 1 
ATOM   138  C CD2 . TYR A 1 29  ? 1.399   -9.636  0.582   1.00 54.41  ?  23  TYR A CD2 1 
ATOM   139  C CE1 . TYR A 1 29  ? -1.066  -8.360  0.871   1.00 48.90  ?  23  TYR A CE1 1 
ATOM   140  C CE2 . TYR A 1 29  ? 0.620   -9.401  -0.523  1.00 51.74  ?  23  TYR A CE2 1 
ATOM   141  C CZ  . TYR A 1 29  ? -0.615  -8.760  -0.372  1.00 50.65  ?  23  TYR A CZ  1 
ATOM   142  O OH  . TYR A 1 29  ? -1.388  -8.525  -1.476  1.00 51.12  ?  23  TYR A OH  1 
ATOM   143  N N   . ALA A 1 30  ? 4.152   -8.913  5.181   1.00 52.21  ?  24  ALA A N   1 
ATOM   144  C CA  . ALA A 1 30  ? 4.690   -8.941  6.549   1.00 56.87  ?  24  ALA A CA  1 
ATOM   145  C C   . ALA A 1 30  ? 5.010   -7.554  7.074   1.00 50.37  ?  24  ALA A C   1 
ATOM   146  O O   . ALA A 1 30  ? 4.880   -7.301  8.277   1.00 50.61  ?  24  ALA A O   1 
ATOM   147  C CB  . ALA A 1 30  ? 5.953   -9.805  6.619   1.00 56.15  ?  24  ALA A CB  1 
ATOM   148  N N   . LEU A 1 31  ? 5.407   -6.641  6.193   1.00 52.61  ?  25  LEU A N   1 
ATOM   149  C CA  . LEU A 1 31  ? 5.658   -5.267  6.622   1.00 55.77  ?  25  LEU A CA  1 
ATOM   150  C C   . LEU A 1 31  ? 4.382   -4.603  7.125   1.00 56.01  ?  25  LEU A C   1 
ATOM   151  O O   . LEU A 1 31  ? 4.393   -3.916  8.153   1.00 58.07  ?  25  LEU A O   1 
ATOM   152  C CB  . LEU A 1 31  ? 6.278   -4.482  5.471   1.00 53.23  ?  25  LEU A CB  1 
ATOM   153  C CG  . LEU A 1 31  ? 6.696   -3.055  5.725   1.00 60.62  ?  25  LEU A CG  1 
ATOM   154  C CD1 . LEU A 1 31  ? 8.029   -2.819  5.052   1.00 64.24  ?  25  LEU A CD1 1 
ATOM   155  C CD2 . LEU A 1 31  ? 5.634   -2.099  5.176   1.00 61.40  ?  25  LEU A CD2 1 
ATOM   156  N N   . GLN A 1 32  ? 3.265   -4.811  6.425   1.00 54.66  ?  26  GLN A N   1 
ATOM   157  C CA  . GLN A 1 32  ? 1.982   -4.333  6.925   1.00 54.45  ?  26  GLN A CA  1 
ATOM   158  C C   . GLN A 1 32  ? 1.600   -4.995  8.246   1.00 57.77  ?  26  GLN A C   1 
ATOM   159  O O   . GLN A 1 32  ? 1.124   -4.316  9.167   1.00 62.42  ?  26  GLN A O   1 
ATOM   160  C CB  . GLN A 1 32  ? 0.903   -4.567  5.882   1.00 54.03  ?  26  GLN A CB  1 
ATOM   161  C CG  . GLN A 1 32  ? 1.368   -4.179  4.509   1.00 61.61  ?  26  GLN A CG  1 
ATOM   162  C CD  . GLN A 1 32  ? 0.281   -4.290  3.474   1.00 63.78  ?  26  GLN A CD  1 
ATOM   163  O OE1 . GLN A 1 32  ? -0.701  -5.005  3.670   1.00 68.67  ?  26  GLN A OE1 1 
ATOM   164  N NE2 . GLN A 1 32  ? 0.451   -3.592  2.356   1.00 65.78  ?  26  GLN A NE2 1 
ATOM   165  N N   . ALA A 1 33  ? 1.786   -6.314  8.365   1.00 48.71  ?  27  ALA A N   1 
ATOM   166  C CA  . ALA A 1 33  ? 1.483   -6.971  9.636   1.00 50.75  ?  27  ALA A CA  1 
ATOM   167  C C   . ALA A 1 33  ? 2.302   -6.385  10.777  1.00 53.27  ?  27  ALA A C   1 
ATOM   168  O O   . ALA A 1 33  ? 1.772   -6.125  11.865  1.00 53.72  ?  27  ALA A O   1 
ATOM   169  C CB  . ALA A 1 33  ? 1.721   -8.475  9.544   1.00 52.95  ?  27  ALA A CB  1 
ATOM   170  N N   . VAL A 1 34  ? 3.605   -6.182  10.557  1.00 53.40  ?  28  VAL A N   1 
ATOM   171  C CA  . VAL A 1 34  ? 4.443   -5.580  11.597  1.00 54.93  ?  28  VAL A CA  1 
ATOM   172  C C   . VAL A 1 34  ? 3.933   -4.183  11.950  1.00 54.62  ?  28  VAL A C   1 
ATOM   173  O O   . VAL A 1 34  ? 3.798   -3.822  13.131  1.00 55.27  ?  28  VAL A O   1 
ATOM   174  C CB  . VAL A 1 34  ? 5.917   -5.540  11.156  1.00 50.75  ?  28  VAL A CB  1 
ATOM   175  C CG1 . VAL A 1 34  ? 6.710   -4.696  12.139  1.00 54.17  ?  28  VAL A CG1 1 
ATOM   176  C CG2 . VAL A 1 34  ? 6.494   -6.940  11.086  1.00 47.50  ?  28  VAL A CG2 1 
ATOM   177  N N   . GLU A 1 35  ? 3.628   -3.379  10.929  1.00 54.79  ?  29  GLU A N   1 
ATOM   178  C CA  . GLU A 1 35  ? 3.144   -2.031  11.192  1.00 55.70  ?  29  GLU A CA  1 
ATOM   179  C C   . GLU A 1 35  ? 1.922   -2.068  12.097  1.00 58.55  ?  29  GLU A C   1 
ATOM   180  O O   . GLU A 1 35  ? 1.915   -1.456  13.169  1.00 61.30  ?  29  GLU A O   1 
ATOM   181  C CB  . GLU A 1 35  ? 2.841   -1.322  9.878   1.00 58.45  ?  29  GLU A CB  1 
ATOM   182  C CG  . GLU A 1 35  ? 2.420   0.148   10.040  1.00 73.63  ?  29  GLU A CG  1 
ATOM   183  C CD  . GLU A 1 35  ? 3.456   0.986   10.812  1.00 90.42  ?  29  GLU A CD  1 
ATOM   184  O OE1 . GLU A 1 35  ? 4.490   1.377   10.207  1.00 88.67  ?  29  GLU A OE1 1 
ATOM   185  O OE2 . GLU A 1 35  ? 3.235   1.251   12.022  1.00 89.23  -1 29  GLU A OE2 1 
ATOM   186  N N   . GLU A 1 36  ? 0.913   -2.863  11.721  1.00 60.85  ?  30  GLU A N   1 
ATOM   187  C CA  . GLU A 1 36  ? -0.356  -2.906  12.445  1.00 56.10  ?  30  GLU A CA  1 
ATOM   188  C C   . GLU A 1 36  ? -0.227  -3.486  13.852  1.00 55.36  ?  30  GLU A C   1 
ATOM   189  O O   . GLU A 1 36  ? -1.071  -3.205  14.707  1.00 58.61  ?  30  GLU A O   1 
ATOM   190  C CB  . GLU A 1 36  ? -1.353  -3.745  11.661  1.00 53.91  ?  30  GLU A CB  1 
ATOM   191  C CG  . GLU A 1 36  ? -2.208  -3.005  10.677  1.00 63.80  ?  30  GLU A CG  1 
ATOM   192  C CD  . GLU A 1 36  ? -2.413  -1.555  11.030  1.00 68.75  ?  30  GLU A CD  1 
ATOM   193  O OE1 . GLU A 1 36  ? -3.134  -1.260  12.033  1.00 64.74  ?  30  GLU A OE1 1 
ATOM   194  O OE2 . GLU A 1 36  ? -1.863  -0.719  10.276  1.00 68.83  -1 30  GLU A OE2 1 
ATOM   195  N N   . ALA A 1 37  ? 0.762   -4.336  14.103  1.00 50.57  ?  31  ALA A N   1 
ATOM   196  C CA  . ALA A 1 37  ? 0.813   -5.011  15.390  1.00 49.90  ?  31  ALA A CA  1 
ATOM   197  C C   . ALA A 1 37  ? 1.205   -4.008  16.478  1.00 57.04  ?  31  ALA A C   1 
ATOM   198  O O   . ALA A 1 37  ? 2.198   -3.280  16.327  1.00 57.93  ?  31  ALA A O   1 
ATOM   199  C CB  . ALA A 1 37  ? 1.781   -6.191  15.345  1.00 48.31  ?  31  ALA A CB  1 
ATOM   200  N N   . PRO A 1 38  ? 0.464   -3.949  17.583  1.00 55.02  ?  32  PRO A N   1 
ATOM   201  C CA  . PRO A 1 38  ? 0.707   -2.901  18.582  1.00 51.77  ?  32  PRO A CA  1 
ATOM   202  C C   . PRO A 1 38  ? 1.940   -3.124  19.415  1.00 60.96  ?  32  PRO A C   1 
ATOM   203  O O   . PRO A 1 38  ? 2.462   -2.150  19.972  1.00 61.24  ?  32  PRO A O   1 
ATOM   204  C CB  . PRO A 1 38  ? -0.545  -2.961  19.463  1.00 59.24  ?  32  PRO A CB  1 
ATOM   205  C CG  . PRO A 1 38  ? -0.987  -4.418  19.358  1.00 59.41  ?  32  PRO A CG  1 
ATOM   206  C CD  . PRO A 1 38  ? -0.705  -4.787  17.917  1.00 56.45  ?  32  PRO A CD  1 
ATOM   207  N N   . ASP A 1 39  ? 2.398   -4.366  19.565  1.00 60.50  ?  33  ASP A N   1 
ATOM   208  C CA  . ASP A 1 39  ? 3.553   -4.662  20.402  1.00 59.90  ?  33  ASP A CA  1 
ATOM   209  C C   . ASP A 1 39  ? 4.848   -4.791  19.598  1.00 62.17  ?  33  ASP A C   1 
ATOM   210  O O   . ASP A 1 39  ? 5.864   -5.222  20.152  1.00 62.28  ?  33  ASP A O   1 
ATOM   211  C CB  . ASP A 1 39  ? 3.311   -5.930  21.243  1.00 52.75  ?  33  ASP A CB  1 
ATOM   212  C CG  . ASP A 1 39  ? 2.840   -7.151  20.397  1.00 61.55  ?  33  ASP A CG  1 
ATOM   213  O OD1 . ASP A 1 39  ? 2.431   -6.955  19.213  1.00 54.56  -1 33  ASP A OD1 1 
ATOM   214  O OD2 . ASP A 1 39  ? 2.878   -8.312  20.931  1.00 57.65  ?  33  ASP A OD2 1 
ATOM   215  N N   . MET A 1 40  ? 4.859   -4.402  18.324  1.00 53.54  ?  34  MET A N   1 
ATOM   216  C CA  . MET A 1 40  ? 6.085   -4.541  17.566  1.00 56.54  ?  34  MET A CA  1 
ATOM   217  C C   . MET A 1 40  ? 6.318   -3.312  16.717  1.00 58.13  ?  34  MET A C   1 
ATOM   218  O O   . MET A 1 40  ? 5.383   -2.584  16.383  1.00 60.48  ?  34  MET A O   1 
ATOM   219  C CB  . MET A 1 40  ? 6.086   -5.765  16.646  1.00 59.88  ?  34  MET A CB  1 
ATOM   220  C CG  . MET A 1 40  ? 5.550   -7.017  17.262  1.00 58.49  ?  34  MET A CG  1 
ATOM   221  S SD  . MET A 1 40  ? 5.067   -8.223  16.018  1.00 61.63  ?  34  MET A SD  1 
ATOM   222  C CE  . MET A 1 40  ? 5.001   -9.668  17.103  1.00 56.08  ?  34  MET A CE  1 
ATOM   223  N N   . GLU A 1 41  ? 7.588   -3.141  16.329  1.00 57.63  ?  35  GLU A N   1 
ATOM   224  C CA  . GLU A 1 41  ? 8.048   -2.086  15.443  1.00 56.16  ?  35  GLU A CA  1 
ATOM   225  C C   . GLU A 1 41  ? 9.063   -2.685  14.478  1.00 54.05  ?  35  GLU A C   1 
ATOM   226  O O   . GLU A 1 41  ? 9.793   -3.617  14.827  1.00 52.18  ?  35  GLU A O   1 
ATOM   227  C CB  . GLU A 1 41  ? 8.663   -0.920  16.238  1.00 58.93  ?  35  GLU A CB  1 
ATOM   228  C CG  . GLU A 1 41  ? 10.049  -1.210  16.781  1.00 66.14  ?  35  GLU A CG  1 
ATOM   229  C CD  . GLU A 1 41  ? 10.759  0.032   17.284  1.00 73.99  ?  35  GLU A CD  1 
ATOM   230  O OE1 . GLU A 1 41  ? 10.059  1.033   17.532  1.00 75.43  ?  35  GLU A OE1 1 
ATOM   231  O OE2 . GLU A 1 41  ? 12.013  0.004   17.422  1.00 77.12  -1 35  GLU A OE2 1 
ATOM   232  N N   . LEU A 1 42  ? 9.090   -2.162  13.253  1.00 49.31  ?  36  LEU A N   1 
ATOM   233  C CA  . LEU A 1 42  ? 9.967   -2.697  12.222  1.00 52.23  ?  36  LEU A CA  1 
ATOM   234  C C   . LEU A 1 42  ? 11.401  -2.224  12.439  1.00 59.29  ?  36  LEU A C   1 
ATOM   235  O O   . LEU A 1 42  ? 11.654  -1.026  12.558  1.00 60.12  ?  36  LEU A O   1 
ATOM   236  C CB  . LEU A 1 42  ? 9.491   -2.258  10.847  1.00 52.22  ?  36  LEU A CB  1 
ATOM   237  C CG  . LEU A 1 42  ? 10.397  -2.684  9.695   1.00 56.54  ?  36  LEU A CG  1 
ATOM   238  C CD1 . LEU A 1 42  ? 10.083  -4.083  9.286   1.00 51.24  ?  36  LEU A CD1 1 
ATOM   239  C CD2 . LEU A 1 42  ? 10.237  -1.746  8.524   1.00 64.43  ?  36  LEU A CD2 1 
ATOM   240  N N   . ALA A 1 43  ? 12.341  -3.163  12.482  1.00 57.55  ?  37  ALA A N   1 
ATOM   241  C CA  . ALA A 1 43  ? 13.751  -2.815  12.625  1.00 61.99  ?  37  ALA A CA  1 
ATOM   242  C C   . ALA A 1 43  ? 14.411  -2.505  11.288  1.00 59.02  ?  37  ALA A C   1 
ATOM   243  O O   . ALA A 1 43  ? 15.374  -1.739  11.233  1.00 59.17  ?  37  ALA A O   1 
ATOM   244  C CB  . ALA A 1 43  ? 14.513  -3.956  13.308  1.00 58.29  ?  37  ALA A CB  1 
ATOM   245  N N   . GLY A 1 44  ? 13.900  -3.072  10.224  1.00 57.81  ?  38  GLY A N   1 
ATOM   246  C CA  . GLY A 1 44  ? 14.487  -2.920  8.913   1.00 60.38  ?  38  GLY A CA  1 
ATOM   247  C C   . GLY A 1 44  ? 14.180  -4.156  8.098   1.00 60.36  ?  38  GLY A C   1 
ATOM   248  O O   . GLY A 1 44  ? 13.586  -5.121  8.583   1.00 56.49  ?  38  GLY A O   1 
ATOM   249  N N   . VAL A 1 45  ? 14.607  -4.104  6.844   1.00 62.98  ?  39  VAL A N   1 
ATOM   250  C CA  . VAL A 1 45  ? 14.480  -5.205  5.900   1.00 62.59  ?  39  VAL A CA  1 
ATOM   251  C C   . VAL A 1 45  ? 15.880  -5.612  5.468   1.00 64.13  ?  39  VAL A C   1 
ATOM   252  O O   . VAL A 1 45  ? 16.732  -4.740  5.254   1.00 63.63  ?  39  VAL A O   1 
ATOM   253  C CB  . VAL A 1 45  ? 13.642  -4.781  4.678   1.00 57.69  ?  39  VAL A CB  1 
ATOM   254  C CG1 . VAL A 1 45  ? 13.466  -5.940  3.734   1.00 58.94  ?  39  VAL A CG1 1 
ATOM   255  C CG2 . VAL A 1 45  ? 12.317  -4.199  5.138   1.00 61.53  ?  39  VAL A CG2 1 
ATOM   256  N N   . VAL A 1 46  ? 16.112  -6.922  5.325   1.00 51.65  ?  40  VAL A N   1 
ATOM   257  C CA  . VAL A 1 46  ? 17.392  -7.451  4.866   1.00 57.14  ?  40  VAL A CA  1 
ATOM   258  C C   . VAL A 1 46  ? 17.193  -8.067  3.486   1.00 61.69  ?  40  VAL A C   1 
ATOM   259  O O   . VAL A 1 46  ? 16.311  -8.918  3.303   1.00 68.15  ?  40  VAL A O   1 
ATOM   260  C CB  . VAL A 1 46  ? 17.967  -8.478  5.849   1.00 57.98  ?  40  VAL A CB  1 
ATOM   261  C CG1 . VAL A 1 46  ? 19.310  -8.981  5.346   1.00 56.43  ?  40  VAL A CG1 1 
ATOM   262  C CG2 . VAL A 1 46  ? 18.082  -7.863  7.260   1.00 57.01  ?  40  VAL A CG2 1 
ATOM   263  N N   . ARG A 1 47  ? 18.008  -7.641  2.512   1.00 64.75  ?  41  ARG A N   1 
ATOM   264  C CA  . ARG A 1 47  ? 17.890  -8.074  1.123   1.00 61.47  ?  41  ARG A CA  1 
ATOM   265  C C   . ARG A 1 47  ? 19.265  -8.482  0.607   1.00 70.33  ?  41  ARG A C   1 
ATOM   266  O O   . ARG A 1 47  ? 20.296  -8.018  1.122   1.00 67.42  ?  41  ARG A O   1 
ATOM   267  C CB  . ARG A 1 47  ? 17.344  -6.946  0.237   1.00 62.52  ?  41  ARG A CB  1 
ATOM   268  C CG  . ARG A 1 47  ? 16.324  -6.058  0.940   1.00 65.45  ?  41  ARG A CG  1 
ATOM   269  C CD  . ARG A 1 47  ? 15.564  -5.199  -0.050  1.00 63.81  ?  41  ARG A CD  1 
ATOM   270  N NE  . ARG A 1 47  ? 15.121  -5.962  -1.211  1.00 66.11  ?  41  ARG A NE  1 
ATOM   271  C CZ  . ARG A 1 47  ? 14.330  -5.481  -2.158  1.00 65.41  ?  41  ARG A CZ  1 
ATOM   272  N NH1 . ARG A 1 47  ? 13.866  -4.244  -2.106  1.00 67.91  ?  41  ARG A NH1 1 
ATOM   273  N NH2 . ARG A 1 47  ? 13.983  -6.266  -3.169  1.00 64.05  ?  41  ARG A NH2 1 
ATOM   274  N N   . ARG A 1 48  ? 19.282  -9.344  -0.424  1.00 62.26  ?  42  ARG A N   1 
ATOM   275  C CA  . ARG A 1 48  ? 20.535  -9.625  -1.131  1.00 71.11  ?  42  ARG A CA  1 
ATOM   276  C C   . ARG A 1 48  ? 21.121  -8.333  -1.708  1.00 76.19  ?  42  ARG A C   1 
ATOM   277  O O   . ARG A 1 48  ? 20.390  -7.391  -2.045  1.00 72.52  ?  42  ARG A O   1 
ATOM   278  C CB  . ARG A 1 48  ? 20.322  -10.633 -2.263  1.00 63.81  ?  42  ARG A CB  1 
ATOM   279  C CG  . ARG A 1 48  ? 19.717  -11.929 -1.836  1.00 63.90  ?  42  ARG A CG  1 
ATOM   280  C CD  . ARG A 1 48  ? 19.109  -12.669 -3.011  1.00 66.48  ?  42  ARG A CD  1 
ATOM   281  N NE  . ARG A 1 48  ? 17.879  -12.034 -3.491  1.00 67.15  ?  42  ARG A NE  1 
ATOM   282  C CZ  . ARG A 1 48  ? 17.259  -12.350 -4.625  1.00 64.96  ?  42  ARG A CZ  1 
ATOM   283  N NH1 . ARG A 1 48  ? 17.688  -13.333 -5.398  1.00 66.43  ?  42  ARG A NH1 1 
ATOM   284  N NH2 . ARG A 1 48  ? 16.184  -11.662 -4.994  1.00 60.28  ?  42  ARG A NH2 1 
ATOM   285  N N   . GLN A 1 49  ? 22.457  -8.298  -1.850  1.00 75.91  ?  43  GLN A N   1 
ATOM   286  C CA  . GLN A 1 49  ? 23.109  -7.081  -2.346  1.00 76.21  ?  43  GLN A CA  1 
ATOM   287  C C   . GLN A 1 49  ? 22.626  -6.730  -3.746  1.00 77.09  ?  43  GLN A C   1 
ATOM   288  O O   . GLN A 1 49  ? 22.489  -5.546  -4.082  1.00 77.08  ?  43  GLN A O   1 
ATOM   289  C CB  . GLN A 1 49  ? 24.628  -7.239  -2.323  1.00 76.12  ?  43  GLN A CB  1 
ATOM   290  C CG  . GLN A 1 49  ? 25.426  -5.960  -2.579  1.00 77.11  ?  43  GLN A CG  1 
ATOM   291  C CD  . GLN A 1 49  ? 25.237  -4.891  -1.509  1.00 78.91  ?  43  GLN A CD  1 
ATOM   292  O OE1 . GLN A 1 49  ? 25.283  -5.176  -0.313  1.00 77.49  ?  43  GLN A OE1 1 
ATOM   293  N NE2 . GLN A 1 49  ? 25.075  -3.642  -1.941  1.00 84.22  ?  43  GLN A NE2 1 
ATOM   294  N N   . SER A 1 50  ? 22.331  -7.752  -4.562  1.00 75.33  ?  44  SER A N   1 
ATOM   295  C CA  . SER A 1 50  ? 21.768  -7.522  -5.891  1.00 75.62  ?  44  SER A CA  1 
ATOM   296  C C   . SER A 1 50  ? 20.530  -6.640  -5.836  1.00 80.15  ?  44  SER A C   1 
ATOM   297  O O   . SER A 1 50  ? 20.386  -5.717  -6.646  1.00 83.80  ?  44  SER A O   1 
ATOM   298  C CB  . SER A 1 50  ? 21.432  -8.849  -6.569  1.00 72.41  ?  44  SER A CB  1 
ATOM   299  O OG  . SER A 1 50  ? 21.993  -9.964  -5.881  1.00 78.71  ?  44  SER A OG  1 
ATOM   300  N N   . SER A 1 51  ? 19.629  -6.897  -4.880  1.00 77.29  ?  45  SER A N   1 
ATOM   301  C CA  . SER A 1 51  ? 18.380  -6.141  -4.828  1.00 78.03  ?  45  SER A CA  1 
ATOM   302  C C   . SER A 1 51  ? 18.596  -4.736  -4.298  1.00 77.12  ?  45  SER A C   1 
ATOM   303  O O   . SER A 1 51  ? 17.831  -3.828  -4.630  1.00 82.68  ?  45  SER A O   1 
ATOM   304  C CB  . SER A 1 51  ? 17.347  -6.867  -3.960  1.00 75.69  ?  45  SER A CB  1 
ATOM   305  O OG  . SER A 1 51  ? 17.180  -8.210  -4.381  1.00 75.63  ?  45  SER A OG  1 
ATOM   306  N N   . LEU A 1 52  ? 19.605  -4.545  -3.449  1.00 78.26  ?  46  LEU A N   1 
ATOM   307  C CA  . LEU A 1 52  ? 19.902  -3.207  -2.956  1.00 80.18  ?  46  LEU A CA  1 
ATOM   308  C C   . LEU A 1 52  ? 20.300  -2.293  -4.101  1.00 84.13  ?  46  LEU A C   1 
ATOM   309  O O   . LEU A 1 52  ? 19.980  -1.095  -4.088  1.00 80.78  ?  46  LEU A O   1 
ATOM   310  C CB  . LEU A 1 52  ? 21.009  -3.283  -1.905  1.00 74.89  ?  46  LEU A CB  1 
ATOM   311  C CG  . LEU A 1 52  ? 20.570  -3.942  -0.589  1.00 76.59  ?  46  LEU A CG  1 
ATOM   312  C CD1 . LEU A 1 52  ? 21.780  -4.308  0.277   1.00 71.60  ?  46  LEU A CD1 1 
ATOM   313  C CD2 . LEU A 1 52  ? 19.570  -3.091  0.194   1.00 62.34  ?  46  LEU A CD2 1 
ATOM   314  N N   . GLU A 1 53  ? 20.974  -2.859  -5.109  1.00 85.07  ?  47  GLU A N   1 
ATOM   315  C CA  . GLU A 1 53  ? 21.398  -2.130  -6.293  1.00 82.81  ?  47  GLU A CA  1 
ATOM   316  C C   . GLU A 1 53  ? 20.227  -1.779  -7.200  1.00 86.26  ?  47  GLU A C   1 
ATOM   317  O O   . GLU A 1 53  ? 20.326  -0.836  -7.992  1.00 91.64  ?  47  GLU A O   1 
ATOM   318  C CB  . GLU A 1 53  ? 22.456  -2.955  -7.028  1.00 80.10  ?  47  GLU A CB  1 
ATOM   319  C CG  . GLU A 1 53  ? 23.768  -3.055  -6.216  1.00 83.99  ?  47  GLU A CG  1 
ATOM   320  C CD  . GLU A 1 53  ? 24.600  -4.295  -6.525  1.00 95.12  ?  47  GLU A CD  1 
ATOM   321  O OE1 . GLU A 1 53  ? 24.317  -4.991  -7.529  1.00 96.44  ?  47  GLU A OE1 1 
ATOM   322  O OE2 . GLU A 1 53  ? 25.547  -4.579  -5.754  1.00 94.79  -1 47  GLU A OE2 1 
ATOM   323  N N   . LYS A 1 54  ? 19.120  -2.490  -7.096  1.00 82.34  ?  48  LYS A N   1 
ATOM   324  C CA  . LYS A 1 54  ? 17.918  -2.044  -7.772  1.00 85.24  ?  48  LYS A CA  1 
ATOM   325  C C   . LYS A 1 54  ? 17.340  -0.858  -7.010  1.00 84.70  ?  48  LYS A C   1 
ATOM   326  O O   . LYS A 1 54  ? 17.706  -0.626  -5.854  1.00 85.65  ?  48  LYS A O   1 
ATOM   327  C CB  . LYS A 1 54  ? 16.915  -3.190  -7.846  1.00 92.21  ?  48  LYS A CB  1 
ATOM   328  C CG  . LYS A 1 54  ? 17.347  -4.276  -8.827  1.00 89.34  ?  48  LYS A CG  1 
ATOM   329  C CD  . LYS A 1 54  ? 16.436  -5.495  -8.787  1.00 90.41  ?  48  LYS A CD  1 
ATOM   330  C CE  . LYS A 1 54  ? 15.357  -5.428  -9.867  1.00 91.70  ?  48  LYS A CE  1 
ATOM   331  N NZ  . LYS A 1 54  ? 14.642  -6.730  -10.004 1.00 86.97  ?  48  LYS A NZ  1 
ATOM   332  N N   . PRO A 1 55  ? 16.466  -0.070  -7.637  1.00 89.79  ?  49  PRO A N   1 
ATOM   333  C CA  . PRO A 1 55  ? 15.961  1.141   -6.976  1.00 84.32  ?  49  PRO A CA  1 
ATOM   334  C C   . PRO A 1 55  ? 15.122  0.824   -5.749  1.00 86.25  ?  49  PRO A C   1 
ATOM   335  O O   . PRO A 1 55  ? 14.642  -0.294  -5.559  1.00 92.38  ?  49  PRO A O   1 
ATOM   336  C CB  . PRO A 1 55  ? 15.121  1.810   -8.068  1.00 80.97  ?  49  PRO A CB  1 
ATOM   337  C CG  . PRO A 1 55  ? 15.736  1.339   -9.328  1.00 83.10  ?  49  PRO A CG  1 
ATOM   338  C CD  . PRO A 1 55  ? 16.078  -0.104  -9.057  1.00 90.48  ?  49  PRO A CD  1 
ATOM   339  N N   . LEU A 1 56  ? 14.951  1.842   -4.904  1.00 84.56  ?  50  LEU A N   1 
ATOM   340  C CA  . LEU A 1 56  ? 14.229  1.652   -3.646  1.00 84.15  ?  50  LEU A CA  1 
ATOM   341  C C   . LEU A 1 56  ? 12.724  1.786   -3.863  1.00 88.49  ?  50  LEU A C   1 
ATOM   342  O O   . LEU A 1 56  ? 12.268  2.807   -4.388  1.00 89.84  ?  50  LEU A O   1 
ATOM   343  C CB  . LEU A 1 56  ? 14.685  2.656   -2.597  1.00 79.59  ?  50  LEU A CB  1 
ATOM   344  C CG  . LEU A 1 56  ? 14.114  2.390   -1.202  1.00 82.84  ?  50  LEU A CG  1 
ATOM   345  C CD1 . LEU A 1 56  ? 14.863  1.265   -0.516  1.00 76.86  ?  50  LEU A CD1 1 
ATOM   346  C CD2 . LEU A 1 56  ? 14.182  3.632   -0.362  1.00 88.84  ?  50  LEU A CD2 1 
ATOM   347  N N   . PRO A 1 57  ? 11.930  0.800   -3.450  1.00 86.92  ?  51  PRO A N   1 
ATOM   348  C CA  . PRO A 1 57  ? 10.468  0.933   -3.519  1.00 82.62  ?  51  PRO A CA  1 
ATOM   349  C C   . PRO A 1 57  ? 9.949   2.040   -2.606  1.00 82.53  ?  51  PRO A C   1 
ATOM   350  O O   . PRO A 1 57  ? 10.573  2.419   -1.614  1.00 87.31  ?  51  PRO A O   1 
ATOM   351  C CB  . PRO A 1 57  ? 9.974   -0.442  -3.049  1.00 84.19  ?  51  PRO A CB  1 
ATOM   352  C CG  . PRO A 1 57  ? 11.142  -1.370  -3.297  1.00 81.74  ?  51  PRO A CG  1 
ATOM   353  C CD  . PRO A 1 57  ? 12.340  -0.533  -2.972  1.00 84.40  ?  51  PRO A CD  1 
ATOM   354  N N   . ARG A 1 58  ? 8.763   2.546   -2.939  1.00 76.91  ?  52  ARG A N   1 
ATOM   355  C CA  . ARG A 1 58  ? 8.240   3.702   -2.216  1.00 84.23  ?  52  ARG A CA  1 
ATOM   356  C C   . ARG A 1 58  ? 7.834   3.350   -0.790  1.00 88.73  ?  52  ARG A C   1 
ATOM   357  O O   . ARG A 1 58  ? 7.919   4.197   0.115   1.00 91.01  ?  52  ARG A O   1 
ATOM   358  C CB  . ARG A 1 58  ? 7.031   4.282   -2.941  1.00 90.36  ?  52  ARG A CB  1 
ATOM   359  C CG  . ARG A 1 58  ? 6.458   5.536   -2.278  1.00 91.00  ?  52  ARG A CG  1 
ATOM   360  C CD  . ARG A 1 58  ? 5.677   6.333   -3.307  1.00 95.38  ?  52  ARG A CD  1 
ATOM   361  N NE  . ARG A 1 58  ? 4.802   5.441   -4.061  1.00 100.66 ?  52  ARG A NE  1 
ATOM   362  C CZ  . ARG A 1 58  ? 3.625   5.785   -4.571  1.00 103.11 ?  52  ARG A CZ  1 
ATOM   363  N NH1 . ARG A 1 58  ? 3.201   7.039   -4.545  1.00 94.80  ?  52  ARG A NH1 1 
ATOM   364  N NH2 . ARG A 1 58  ? 2.843   4.841   -5.100  1.00 98.14  ?  52  ARG A NH2 1 
ATOM   365  N N   . GLU A 1 59  ? 7.320   2.133   -0.581  1.00 86.67  ?  53  GLU A N   1 
ATOM   366  C CA  . GLU A 1 59  ? 6.831   1.750   0.737   1.00 82.61  ?  53  GLU A CA  1 
ATOM   367  C C   . GLU A 1 59  ? 7.976   1.654   1.732   1.00 81.37  ?  53  GLU A C   1 
ATOM   368  O O   . GLU A 1 59  ? 7.743   1.733   2.942   1.00 82.43  ?  53  GLU A O   1 
ATOM   369  C CB  . GLU A 1 59  ? 6.071   0.415   0.627   1.00 70.62  ?  53  GLU A CB  1 
ATOM   370  C CG  . GLU A 1 59  ? 6.917   -0.675  0.015   1.00 76.68  ?  53  GLU A CG  1 
ATOM   371  C CD  . GLU A 1 59  ? 6.739   -0.818  -1.480  1.00 81.88  ?  53  GLU A CD  1 
ATOM   372  O OE1 . GLU A 1 59  ? 6.524   0.213   -2.159  1.00 81.21  ?  53  GLU A OE1 1 
ATOM   373  O OE2 . GLU A 1 59  ? 6.895   -1.953  -1.985  1.00 87.01  -1 53  GLU A OE2 1 
ATOM   374  N N   . LEU A 1 60  ? 9.211   1.518   1.237   1.00 77.37  ?  54  LEU A N   1 
ATOM   375  C CA  . LEU A 1 60  ? 10.416  1.386   2.044   1.00 80.08  ?  54  LEU A CA  1 
ATOM   376  C C   . LEU A 1 60  ? 11.122  2.728   2.263   1.00 81.60  ?  54  LEU A C   1 
ATOM   377  O O   . LEU A 1 60  ? 12.266  2.749   2.733   1.00 81.61  ?  54  LEU A O   1 
ATOM   378  C CB  . LEU A 1 60  ? 11.389  0.388   1.375   1.00 75.50  ?  54  LEU A CB  1 
ATOM   379  C CG  . LEU A 1 60  ? 10.929  -1.068  1.159   1.00 72.35  ?  54  LEU A CG  1 
ATOM   380  C CD1 . LEU A 1 60  ? 12.022  -1.921  0.534   1.00 63.50  ?  54  LEU A CD1 1 
ATOM   381  C CD2 . LEU A 1 60  ? 10.415  -1.730  2.441   1.00 68.12  ?  54  LEU A CD2 1 
ATOM   382  N N   . HIS A 1 61  ? 10.480  3.845   1.929   1.00 83.38  ?  55  HIS A N   1 
ATOM   383  C CA  . HIS A 1 61  ? 11.076  5.149   2.197   1.00 86.63  ?  55  HIS A CA  1 
ATOM   384  C C   . HIS A 1 61  ? 11.068  5.397   3.699   1.00 80.42  ?  55  HIS A C   1 
ATOM   385  O O   . HIS A 1 61  ? 10.016  5.340   4.344   1.00 80.10  ?  55  HIS A O   1 
ATOM   386  C CB  . HIS A 1 61  ? 10.323  6.258   1.463   1.00 89.47  ?  55  HIS A CB  1 
ATOM   387  C CG  . HIS A 1 61  ? 10.707  6.396   0.018   1.00 94.07  ?  55  HIS A CG  1 
ATOM   388  N ND1 . HIS A 1 61  ? 10.198  7.384   -0.800  1.00 94.23  ?  55  HIS A ND1 1 
ATOM   389  C CD2 . HIS A 1 61  ? 11.535  5.656   -0.760  1.00 91.69  ?  55  HIS A CD2 1 
ATOM   390  C CE1 . HIS A 1 61  ? 10.698  7.248   -2.016  1.00 89.21  ?  55  HIS A CE1 1 
ATOM   391  N NE2 . HIS A 1 61  ? 11.511  6.207   -2.019  1.00 89.11  ?  55  HIS A NE2 1 
ATOM   392  N N   . GLY A 1 62  ? 12.237  5.665   4.258   1.00 79.74  ?  56  GLY A N   1 
ATOM   393  C CA  . GLY A 1 62  ? 12.363  5.783   5.692   1.00 76.98  ?  56  GLY A CA  1 
ATOM   394  C C   . GLY A 1 62  ? 12.567  4.471   6.402   1.00 69.52  ?  56  GLY A C   1 
ATOM   395  O O   . GLY A 1 62  ? 12.513  4.441   7.634   1.00 72.03  ?  56  GLY A O   1 
ATOM   396  N N   . VAL A 1 63  ? 12.797  3.389   5.666   1.00 69.15  ?  57  VAL A N   1 
ATOM   397  C CA  . VAL A 1 63  ? 13.015  2.064   6.233   1.00 71.60  ?  57  VAL A CA  1 
ATOM   398  C C   . VAL A 1 63  ? 14.479  1.696   6.044   1.00 63.83  ?  57  VAL A C   1 
ATOM   399  O O   . VAL A 1 63  ? 14.993  1.726   4.921   1.00 61.20  ?  57  VAL A O   1 
ATOM   400  C CB  . VAL A 1 63  ? 12.105  1.009   5.579   1.00 68.43  ?  57  VAL A CB  1 
ATOM   401  C CG1 . VAL A 1 63  ? 12.582  -0.387  5.935   1.00 67.49  ?  57  VAL A CG1 1 
ATOM   402  C CG2 . VAL A 1 63  ? 10.659  1.212   5.979   1.00 67.88  ?  57  VAL A CG2 1 
ATOM   403  N N   . SER A 1 64  ? 15.142  1.329   7.132   1.00 64.82  ?  58  SER A N   1 
ATOM   404  C CA  . SER A 1 64  ? 16.470  0.745   7.018   1.00 63.13  ?  58  SER A CA  1 
ATOM   405  C C   . SER A 1 64  ? 16.407  -0.513  6.151   1.00 65.92  ?  58  SER A C   1 
ATOM   406  O O   . SER A 1 64  ? 15.661  -1.456  6.454   1.00 64.39  ?  58  SER A O   1 
ATOM   407  C CB  . SER A 1 64  ? 17.003  0.417   8.397   1.00 58.89  ?  58  SER A CB  1 
ATOM   408  O OG  . SER A 1 64  ? 17.529  1.581   8.993   1.00 70.02  ?  58  SER A OG  1 
ATOM   409  N N   . VAL A 1 65  ? 17.166  -0.518  5.057   1.00 62.30  ?  59  VAL A N   1 
ATOM   410  C CA  . VAL A 1 65  ? 17.160  -1.615  4.093   1.00 64.83  ?  59  VAL A CA  1 
ATOM   411  C C   . VAL A 1 65  ? 18.612  -1.978  3.802   1.00 58.99  ?  59  VAL A C   1 
ATOM   412  O O   . VAL A 1 65  ? 19.336  -1.198  3.174   1.00 66.69  ?  59  VAL A O   1 
ATOM   413  C CB  . VAL A 1 65  ? 16.415  -1.244  2.806   1.00 63.96  ?  59  VAL A CB  1 
ATOM   414  C CG1 . VAL A 1 65  ? 16.510  -2.366  1.796   1.00 64.31  ?  59  VAL A CG1 1 
ATOM   415  C CG2 . VAL A 1 65  ? 14.966  -0.937  3.109   1.00 62.91  ?  59  VAL A CG2 1 
ATOM   416  N N   . VAL A 1 66  ? 19.043  -3.154  4.254   1.00 60.47  ?  60  VAL A N   1 
ATOM   417  C CA  . VAL A 1 66  ? 20.460  -3.492  4.375   1.00 62.57  ?  60  VAL A CA  1 
ATOM   418  C C   . VAL A 1 66  ? 20.685  -4.916  3.877   1.00 65.99  ?  60  VAL A C   1 
ATOM   419  O O   . VAL A 1 66  ? 19.734  -5.648  3.597   1.00 65.79  ?  60  VAL A O   1 
ATOM   420  C CB  . VAL A 1 66  ? 20.936  -3.380  5.830   1.00 60.20  ?  60  VAL A CB  1 
ATOM   421  C CG1 . VAL A 1 66  ? 20.535  -2.047  6.416   1.00 54.00  ?  60  VAL A CG1 1 
ATOM   422  C CG2 . VAL A 1 66  ? 20.370  -4.529  6.599   1.00 65.64  ?  60  VAL A CG2 1 
ATOM   423  N N   . SER A 1 67  ? 21.967  -5.324  3.804   1.00 63.60  ?  61  SER A N   1 
ATOM   424  C CA  . SER A 1 67  ? 22.309  -6.672  3.346   1.00 63.61  ?  61  SER A CA  1 
ATOM   425  C C   . SER A 1 67  ? 22.616  -7.670  4.463   1.00 62.99  ?  61  SER A C   1 
ATOM   426  O O   . SER A 1 67  ? 22.744  -8.869  4.177   1.00 60.55  ?  61  SER A O   1 
ATOM   427  C CB  . SER A 1 67  ? 23.534  -6.635  2.410   1.00 66.74  ?  61  SER A CB  1 
ATOM   428  O OG  . SER A 1 67  ? 24.711  -6.242  3.104   1.00 71.24  ?  61  SER A OG  1 
ATOM   429  N N   . ASP A 1 68  ? 22.793  -7.215  5.700   1.00 64.66  ?  62  ASP A N   1 
ATOM   430  C CA  . ASP A 1 68  ? 22.997  -8.097  6.841   1.00 64.00  ?  62  ASP A CA  1 
ATOM   431  C C   . ASP A 1 68  ? 22.245  -7.522  8.032   1.00 64.89  ?  62  ASP A C   1 
ATOM   432  O O   . ASP A 1 68  ? 22.132  -6.303  8.188   1.00 61.97  ?  62  ASP A O   1 
ATOM   433  C CB  . ASP A 1 68  ? 24.472  -8.255  7.220   1.00 63.51  ?  62  ASP A CB  1 
ATOM   434  C CG  . ASP A 1 68  ? 24.682  -9.193  8.415   1.00 66.19  ?  62  ASP A CG  1 
ATOM   435  O OD1 . ASP A 1 68  ? 24.678  -10.423 8.232   1.00 72.82  ?  62  ASP A OD1 1 
ATOM   436  O OD2 . ASP A 1 68  ? 24.813  -8.704  9.553   1.00 71.20  -1 62  ASP A OD2 1 
ATOM   437  N N   . VAL A 1 69  ? 21.748  -8.415  8.887   1.00 58.93  ?  63  VAL A N   1 
ATOM   438  C CA  . VAL A 1 69  ? 20.986  -8.000  10.055  1.00 62.65  ?  63  VAL A CA  1 
ATOM   439  C C   . VAL A 1 69  ? 21.819  -7.223  11.073  1.00 62.94  ?  63  VAL A C   1 
ATOM   440  O O   . VAL A 1 69  ? 21.248  -6.478  11.883  1.00 61.78  ?  63  VAL A O   1 
ATOM   441  C CB  . VAL A 1 69  ? 20.304  -9.262  10.639  1.00 62.14  ?  63  VAL A CB  1 
ATOM   442  C CG1 . VAL A 1 69  ? 21.311  -10.177 11.327  1.00 61.25  ?  63  VAL A CG1 1 
ATOM   443  C CG2 . VAL A 1 69  ? 19.175  -8.885  11.573  1.00 57.83  ?  63  VAL A CG2 1 
ATOM   444  N N   . SER A 1 70  ? 23.145  -7.328  11.018  1.00 63.62  ?  64  SER A N   1 
ATOM   445  C CA  . SER A 1 70  ? 24.009  -6.565  11.956  1.00 69.66  ?  64  SER A CA  1 
ATOM   446  C C   . SER A 1 70  ? 23.775  -5.068  11.761  1.00 71.19  ?  64  SER A C   1 
ATOM   447  O O   . SER A 1 70  ? 23.750  -4.340  12.767  1.00 73.72  ?  64  SER A O   1 
ATOM   448  C CB  . SER A 1 70  ? 25.455  -6.892  11.777  1.00 64.57  ?  64  SER A CB  1 
ATOM   449  O OG  . SER A 1 70  ? 25.876  -6.559  10.463  1.00 72.73  ?  64  SER A OG  1 
ATOM   450  N N   . ALA A 1 71  ? 23.612  -4.641  10.512  1.00 66.06  ?  65  ALA A N   1 
ATOM   451  C CA  . ALA A 1 71  ? 23.362  -3.233  10.224  1.00 65.26  ?  65  ALA A CA  1 
ATOM   452  C C   . ALA A 1 71  ? 22.048  -2.731  10.814  1.00 69.92  ?  65  ALA A C   1 
ATOM   453  O O   . ALA A 1 71  ? 21.819  -1.518  10.850  1.00 67.57  ?  65  ALA A O   1 
ATOM   454  C CB  . ALA A 1 71  ? 23.361  -2.994  8.719   1.00 63.84  ?  65  ALA A CB  1 
ATOM   455  N N   . LEU A 1 72  ? 21.162  -3.625  11.234  1.00 77.28  ?  66  LEU A N   1 
ATOM   456  C CA  . LEU A 1 72  ? 19.904  -3.187  11.822  1.00 78.52  ?  66  LEU A CA  1 
ATOM   457  C C   . LEU A 1 72  ? 20.047  -2.902  13.297  1.00 79.72  ?  66  LEU A C   1 
ATOM   458  O O   . LEU A 1 72  ? 19.364  -2.017  13.814  1.00 77.89  ?  66  LEU A O   1 
ATOM   459  C CB  . LEU A 1 72  ? 18.823  -4.233  11.593  1.00 75.47  ?  66  LEU A CB  1 
ATOM   460  C CG  . LEU A 1 72  ? 17.864  -3.928  10.453  1.00 73.03  ?  66  LEU A CG  1 
ATOM   461  C CD1 . LEU A 1 72  ? 18.592  -3.417  9.270   1.00 68.76  ?  66  LEU A CD1 1 
ATOM   462  C CD2 . LEU A 1 72  ? 17.113  -5.215  10.075  1.00 64.02  ?  66  LEU A CD2 1 
ATOM   463  N N   . GLY A 1 73  ? 20.953  -3.601  13.961  1.00 84.97  ?  67  GLY A N   1 
ATOM   464  C CA  . GLY A 1 73  ? 21.200  -3.372  15.359  1.00 78.68  ?  67  GLY A CA  1 
ATOM   465  C C   . GLY A 1 73  ? 20.004  -3.668  16.233  1.00 82.39  ?  67  GLY A C   1 
ATOM   466  O O   . GLY A 1 73  ? 18.967  -2.997  16.141  1.00 88.40  ?  67  GLY A O   1 
ATOM   467  N N   . GLN A 1 74  ? 20.143  -4.668  17.097  1.00 78.81  ?  68  GLN A N   1 
ATOM   468  C CA  . GLN A 1 74  ? 19.108  -5.005  18.069  1.00 76.35  ?  68  GLN A CA  1 
ATOM   469  C C   . GLN A 1 74  ? 17.842  -5.481  17.366  1.00 74.32  ?  68  GLN A C   1 
ATOM   470  O O   . GLN A 1 74  ? 16.916  -4.709  17.094  1.00 74.59  ?  68  GLN A O   1 
ATOM   471  C CB  . GLN A 1 74  ? 18.825  -3.831  19.000  1.00 77.18  ?  68  GLN A CB  1 
ATOM   472  C CG  . GLN A 1 74  ? 18.504  -4.267  20.419  1.00 84.10  ?  68  GLN A CG  1 
ATOM   473  C CD  . GLN A 1 74  ? 17.453  -5.363  20.460  1.00 81.60  ?  68  GLN A CD  1 
ATOM   474  O OE1 . GLN A 1 74  ? 16.280  -5.115  20.176  1.00 85.50  ?  68  GLN A OE1 1 
ATOM   475  N NE2 . GLN A 1 74  ? 17.865  -6.580  20.827  1.00 79.53  ?  68  GLN A NE2 1 
ATOM   476  N N   . VAL A 1 75  ? 17.814  -6.770  17.078  1.00 65.48  ?  69  VAL A N   1 
ATOM   477  C CA  . VAL A 1 75  ? 16.721  -7.425  16.392  1.00 67.22  ?  69  VAL A CA  1 
ATOM   478  C C   . VAL A 1 75  ? 16.252  -8.543  17.316  1.00 65.73  ?  69  VAL A C   1 
ATOM   479  O O   . VAL A 1 75  ? 17.008  -9.487  17.578  1.00 64.75  ?  69  VAL A O   1 
ATOM   480  C CB  . VAL A 1 75  ? 17.181  -7.963  15.032  1.00 61.95  ?  69  VAL A CB  1 
ATOM   481  C CG1 . VAL A 1 75  ? 16.127  -8.868  14.394  1.00 52.41  ?  69  VAL A CG1 1 
ATOM   482  C CG2 . VAL A 1 75  ? 17.612  -6.789  14.130  1.00 60.72  ?  69  VAL A CG2 1 
ATOM   483  N N   . ASP A 1 76  ? 15.029  -8.427  17.843  1.00 61.66  ?  70  ASP A N   1 
ATOM   484  C CA  . ASP A 1 76  ? 14.482  -9.523  18.634  1.00 57.64  ?  70  ASP A CA  1 
ATOM   485  C C   . ASP A 1 76  ? 14.150  -10.734 17.755  1.00 60.30  ?  70  ASP A C   1 
ATOM   486  O O   . ASP A 1 76  ? 14.529  -11.870 18.076  1.00 53.50  ?  70  ASP A O   1 
ATOM   487  C CB  . ASP A 1 76  ? 13.244  -9.057  19.401  1.00 59.43  ?  70  ASP A CB  1 
ATOM   488  C CG  . ASP A 1 76  ? 13.543  -7.958  20.413  1.00 63.66  ?  70  ASP A CG  1 
ATOM   489  O OD1 . ASP A 1 76  ? 14.525  -8.075  21.179  1.00 62.22  ?  70  ASP A OD1 1 
ATOM   490  O OD2 . ASP A 1 76  ? 12.771  -6.981  20.453  1.00 65.38  -1 70  ASP A OD2 1 
ATOM   491  N N   . VAL A 1 77  ? 13.454  -10.512 16.638  1.00 52.27  ?  71  VAL A N   1 
ATOM   492  C CA  . VAL A 1 77  ? 12.921  -11.594 15.829  1.00 50.37  ?  71  VAL A CA  1 
ATOM   493  C C   . VAL A 1 77  ? 13.200  -11.307 14.363  1.00 53.40  ?  71  VAL A C   1 
ATOM   494  O O   . VAL A 1 77  ? 13.060  -10.169 13.908  1.00 57.15  ?  71  VAL A O   1 
ATOM   495  C CB  . VAL A 1 77  ? 11.401  -11.780 16.063  1.00 54.42  ?  71  VAL A CB  1 
ATOM   496  C CG1 . VAL A 1 77  ? 10.865  -12.886 15.166  1.00 51.57  ?  71  VAL A CG1 1 
ATOM   497  C CG2 . VAL A 1 77  ? 11.082  -12.067 17.542  1.00 47.26  ?  71  VAL A CG2 1 
ATOM   498  N N   . ALA A 1 78  ? 13.597  -12.337 13.626  1.00 51.04  ?  72  ALA A N   1 
ATOM   499  C CA  . ALA A 1 78  ? 13.746  -12.272 12.182  1.00 52.35  ?  72  ALA A CA  1 
ATOM   500  C C   . ALA A 1 78  ? 12.619  -13.085 11.555  1.00 56.25  ?  72  ALA A C   1 
ATOM   501  O O   . ALA A 1 78  ? 12.441  -14.266 11.882  1.00 60.74  ?  72  ALA A O   1 
ATOM   502  C CB  . ALA A 1 78  ? 15.114  -12.810 11.744  1.00 48.65  ?  72  ALA A CB  1 
ATOM   503  N N   . VAL A 1 79  ? 11.846  -12.452 10.684  1.00 55.06  ?  73  VAL A N   1 
ATOM   504  C CA  . VAL A 1 79  ? 10.721  -13.086 10.008  1.00 55.85  ?  73  VAL A CA  1 
ATOM   505  C C   . VAL A 1 79  ? 11.220  -13.455 8.616   1.00 58.81  ?  73  VAL A C   1 
ATOM   506  O O   . VAL A 1 79  ? 11.343  -12.599 7.734   1.00 57.57  ?  73  VAL A O   1 
ATOM   507  C CB  . VAL A 1 79  ? 9.494   -12.169 9.958   1.00 56.43  ?  73  VAL A CB  1 
ATOM   508  C CG1 . VAL A 1 79  ? 8.449   -12.734 8.983   1.00 54.10  ?  73  VAL A CG1 1 
ATOM   509  C CG2 . VAL A 1 79  ? 8.888   -11.985 11.364  1.00 49.79  ?  73  VAL A CG2 1 
ATOM   510  N N   . LEU A 1 80  ? 11.529  -14.728 8.416   1.00 56.70  ?  74  LEU A N   1 
ATOM   511  C CA  . LEU A 1 80  ? 12.155  -15.165 7.174   1.00 56.71  ?  74  LEU A CA  1 
ATOM   512  C C   . LEU A 1 80  ? 11.106  -15.274 6.075   1.00 62.56  ?  74  LEU A C   1 
ATOM   513  O O   . LEU A 1 80  ? 10.217  -16.125 6.141   1.00 61.55  ?  74  LEU A O   1 
ATOM   514  C CB  . LEU A 1 80  ? 12.849  -16.503 7.379   1.00 57.08  ?  74  LEU A CB  1 
ATOM   515  C CG  . LEU A 1 80  ? 14.196  -16.538 8.098   1.00 60.57  ?  74  LEU A CG  1 
ATOM   516  C CD1 . LEU A 1 80  ? 14.315  -15.555 9.251   1.00 59.23  ?  74  LEU A CD1 1 
ATOM   517  C CD2 . LEU A 1 80  ? 14.386  -17.927 8.600   1.00 62.21  ?  74  LEU A CD2 1 
ATOM   518  N N   . CYS A 1 81  ? 11.221  -14.445 5.047   1.00 60.86  ?  75  CYS A N   1 
ATOM   519  C CA  . CYS A 1 81  ? 10.330  -14.496 3.895   1.00 53.53  ?  75  CYS A CA  1 
ATOM   520  C C   . CYS A 1 81  ? 11.084  -14.939 2.645   1.00 60.08  ?  75  CYS A C   1 
ATOM   521  O O   . CYS A 1 81  ? 10.860  -14.437 1.544   1.00 60.75  ?  75  CYS A O   1 
ATOM   522  C CB  . CYS A 1 81  ? 9.665   -13.143 3.695   1.00 58.24  ?  75  CYS A CB  1 
ATOM   523  S SG  . CYS A 1 81  ? 8.989   -12.467 5.258   1.00 56.76  ?  75  CYS A SG  1 
ATOM   524  N N   . THR A 1 82  ? 11.997  -15.905 2.817   1.00 62.67  ?  76  THR A N   1 
ATOM   525  C CA  . THR A 1 82  ? 12.948  -16.369 1.821   1.00 61.32  ?  76  THR A CA  1 
ATOM   526  C C   . THR A 1 82  ? 12.447  -17.635 1.139   1.00 61.99  ?  76  THR A C   1 
ATOM   527  O O   . THR A 1 82  ? 11.535  -18.302 1.631   1.00 57.72  ?  76  THR A O   1 
ATOM   528  C CB  . THR A 1 82  ? 14.314  -16.614 2.476   1.00 61.89  ?  76  THR A CB  1 
ATOM   529  O OG1 . THR A 1 82  ? 14.138  -17.139 3.797   1.00 62.09  ?  76  THR A OG1 1 
ATOM   530  C CG2 . THR A 1 82  ? 15.074  -15.313 2.569   1.00 62.24  ?  76  THR A CG2 1 
ATOM   531  N N   . PRO A 1 83  ? 12.992  -17.980 -0.027  1.00 65.21  ?  77  PRO A N   1 
ATOM   532  C CA  . PRO A 1 83  ? 12.532  -19.198 -0.714  1.00 62.84  ?  77  PRO A CA  1 
ATOM   533  C C   . PRO A 1 83  ? 12.726  -20.420 0.160   1.00 63.57  ?  77  PRO A C   1 
ATOM   534  O O   . PRO A 1 83  ? 13.700  -20.523 0.911   1.00 68.15  ?  77  PRO A O   1 
ATOM   535  C CB  . PRO A 1 83  ? 13.416  -19.265 -1.963  1.00 67.24  ?  77  PRO A CB  1 
ATOM   536  C CG  . PRO A 1 83  ? 13.888  -17.846 -2.171  1.00 68.50  ?  77  PRO A CG  1 
ATOM   537  C CD  . PRO A 1 83  ? 13.988  -17.228 -0.812  1.00 62.86  ?  77  PRO A CD  1 
ATOM   538  N N   . THR A 1 84  ? 11.773  -21.348 0.061   1.00 67.56  ?  78  THR A N   1 
ATOM   539  C CA  . THR A 1 84  ? 11.785  -22.556 0.884   1.00 66.24  ?  78  THR A CA  1 
ATOM   540  C C   . THR A 1 84  ? 13.167  -23.191 0.997   1.00 67.31  ?  78  THR A C   1 
ATOM   541  O O   . THR A 1 84  ? 13.673  -23.407 2.102   1.00 66.97  ?  78  THR A O   1 
ATOM   542  C CB  . THR A 1 84  ? 10.800  -23.571 0.313   1.00 69.22  ?  78  THR A CB  1 
ATOM   543  O OG1 . THR A 1 84  ? 9.484   -23.002 0.298   1.00 68.29  ?  78  THR A OG1 1 
ATOM   544  C CG2 . THR A 1 84  ? 10.822  -24.855 1.143   1.00 66.86  ?  78  THR A CG2 1 
ATOM   545  N N   . ARG A 1 85  ? 13.799  -23.477 -0.144  1.00 69.14  ?  79  ARG A N   1 
ATOM   546  C CA  . ARG A 1 85  ? 15.069  -24.201 -0.128  1.00 71.64  ?  79  ARG A CA  1 
ATOM   547  C C   . ARG A 1 85  ? 16.127  -23.484 0.699   1.00 70.54  ?  79  ARG A C   1 
ATOM   548  O O   . ARG A 1 85  ? 16.932  -24.129 1.379   1.00 74.07  ?  79  ARG A O   1 
ATOM   549  C CB  . ARG A 1 85  ? 15.574  -24.411 -1.552  1.00 76.84  ?  79  ARG A CB  1 
ATOM   550  C CG  . ARG A 1 85  ? 15.247  -25.766 -2.131  1.00 84.51  ?  79  ARG A CG  1 
ATOM   551  C CD  . ARG A 1 85  ? 16.465  -26.334 -2.842  1.00 97.74  ?  79  ARG A CD  1 
ATOM   552  N NE  . ARG A 1 85  ? 16.638  -25.721 -4.155  1.00 102.28 ?  79  ARG A NE  1 
ATOM   553  C CZ  . ARG A 1 85  ? 17.713  -25.043 -4.536  1.00 102.69 ?  79  ARG A CZ  1 
ATOM   554  N NH1 . ARG A 1 85  ? 18.747  -24.867 -3.725  1.00 97.98  ?  79  ARG A NH1 1 
ATOM   555  N NH2 . ARG A 1 85  ? 17.754  -24.533 -5.765  1.00 100.64 ?  79  ARG A NH2 1 
ATOM   556  N N   . GLU A 1 86  ? 16.145  -22.158 0.664   1.00 66.66  ?  80  GLU A N   1 
ATOM   557  C CA  . GLU A 1 86  ? 17.242  -21.420 1.275   1.00 64.99  ?  80  GLU A CA  1 
ATOM   558  C C   . GLU A 1 86  ? 17.018  -21.109 2.750   1.00 64.28  ?  80  GLU A C   1 
ATOM   559  O O   . GLU A 1 86  ? 17.949  -20.638 3.423   1.00 63.77  ?  80  GLU A O   1 
ATOM   560  C CB  . GLU A 1 86  ? 17.474  -20.112 0.499   1.00 69.36  ?  80  GLU A CB  1 
ATOM   561  C CG  . GLU A 1 86  ? 18.614  -20.176 -0.521  1.00 72.29  ?  80  GLU A CG  1 
ATOM   562  C CD  . GLU A 1 86  ? 18.230  -20.930 -1.783  1.00 81.75  ?  80  GLU A CD  1 
ATOM   563  O OE1 . GLU A 1 86  ? 17.056  -20.816 -2.219  1.00 83.33  ?  80  GLU A OE1 1 
ATOM   564  O OE2 . GLU A 1 86  ? 19.094  -21.657 -2.330  1.00 85.19  -1 80  GLU A OE2 1 
ATOM   565  N N   . THR A 1 87  ? 15.817  -21.362 3.267   1.00 65.94  ?  81  THR A N   1 
ATOM   566  C CA  . THR A 1 87  ? 15.380  -20.798 4.542   1.00 60.97  ?  81  THR A CA  1 
ATOM   567  C C   . THR A 1 87  ? 15.924  -21.531 5.764   1.00 56.35  ?  81  THR A C   1 
ATOM   568  O O   . THR A 1 87  ? 16.340  -20.862 6.720   1.00 54.69  ?  81  THR A O   1 
ATOM   569  C CB  . THR A 1 87  ? 13.854  -20.752 4.591   1.00 61.24  ?  81  THR A CB  1 
ATOM   570  O OG1 . THR A 1 87  ? 13.406  -19.812 3.617   1.00 64.09  ?  81  THR A OG1 1 
ATOM   571  C CG2 . THR A 1 87  ? 13.357  -20.310 5.971   1.00 56.90  ?  81  THR A CG2 1 
ATOM   572  N N   . PRO A 1 88  ? 15.928  -22.875 5.807   1.00 59.05  ?  82  PRO A N   1 
ATOM   573  C CA  . PRO A 1 88  ? 16.515  -23.537 6.998   1.00 59.93  ?  82  PRO A CA  1 
ATOM   574  C C   . PRO A 1 88  ? 17.940  -23.091 7.268   1.00 59.97  ?  82  PRO A C   1 
ATOM   575  O O   . PRO A 1 88  ? 18.289  -22.825 8.429   1.00 61.28  ?  82  PRO A O   1 
ATOM   576  C CB  . PRO A 1 88  ? 16.425  -25.041 6.666   1.00 53.48  ?  82  PRO A CB  1 
ATOM   577  C CG  . PRO A 1 88  ? 15.337  -25.150 5.645   1.00 59.52  ?  82  PRO A CG  1 
ATOM   578  C CD  . PRO A 1 88  ? 15.364  -23.854 4.852   1.00 59.35  ?  82  PRO A CD  1 
ATOM   579  N N   . ALA A 1 89  ? 18.760  -22.946 6.212   1.00 60.46  ?  83  ALA A N   1 
ATOM   580  C CA  . ALA A 1 89  ? 20.127  -22.455 6.386   1.00 61.46  ?  83  ALA A CA  1 
ATOM   581  C C   . ALA A 1 89  ? 20.152  -21.005 6.852   1.00 62.19  ?  83  ALA A C   1 
ATOM   582  O O   . ALA A 1 89  ? 20.986  -20.635 7.691   1.00 66.08  ?  83  ALA A O   1 
ATOM   583  C CB  . ALA A 1 89  ? 20.915  -22.606 5.086   1.00 63.65  ?  83  ALA A CB  1 
ATOM   584  N N   . ILE A 1 90  ? 19.256  -20.160 6.326   1.00 57.77  ?  84  ILE A N   1 
ATOM   585  C CA  . ILE A 1 90  ? 19.229  -18.779 6.803   1.00 57.02  ?  84  ILE A CA  1 
ATOM   586  C C   . ILE A 1 90  ? 18.789  -18.725 8.264   1.00 55.91  ?  84  ILE A C   1 
ATOM   587  O O   . ILE A 1 90  ? 19.387  -18.007 9.075   1.00 54.80  ?  84  ILE A O   1 
ATOM   588  C CB  . ILE A 1 90  ? 18.339  -17.911 5.901   1.00 61.11  ?  84  ILE A CB  1 
ATOM   589  C CG1 . ILE A 1 90  ? 18.969  -17.840 4.508   1.00 62.15  ?  84  ILE A CG1 1 
ATOM   590  C CG2 . ILE A 1 90  ? 18.227  -16.484 6.481   1.00 51.08  ?  84  ILE A CG2 1 
ATOM   591  C CD1 . ILE A 1 90  ? 18.103  -17.220 3.455   1.00 62.74  ?  84  ILE A CD1 1 
ATOM   592  N N   . ALA A 1 91  ? 17.765  -19.510 8.634   1.00 51.37  ?  85  ALA A N   1 
ATOM   593  C CA  . ALA A 1 91  ? 17.317  -19.550 10.027  1.00 57.31  ?  85  ALA A CA  1 
ATOM   594  C C   . ALA A 1 91  ? 18.444  -19.959 10.974  1.00 60.28  ?  85  ALA A C   1 
ATOM   595  O O   . ALA A 1 91  ? 18.652  -19.315 12.014  1.00 56.46  ?  85  ALA A O   1 
ATOM   596  C CB  . ALA A 1 91  ? 16.122  -20.495 10.179  1.00 59.19  ?  85  ALA A CB  1 
ATOM   597  N N   . LYS A 1 92  ? 19.186  -21.026 10.635  1.00 59.63  ?  86  LYS A N   1 
ATOM   598  C CA  . LYS A 1 92  ? 20.300  -21.450 11.490  1.00 62.81  ?  86  LYS A CA  1 
ATOM   599  C C   . LYS A 1 92  ? 21.253  -20.295 11.814  1.00 63.88  ?  86  LYS A C   1 
ATOM   600  O O   . LYS A 1 92  ? 21.608  -20.089 12.982  1.00 64.69  ?  86  LYS A O   1 
ATOM   601  C CB  . LYS A 1 92  ? 21.062  -22.602 10.846  1.00 63.23  ?  86  LYS A CB  1 
ATOM   602  C CG  . LYS A 1 92  ? 20.590  -23.961 11.293  1.00 69.55  ?  86  LYS A CG  1 
ATOM   603  C CD  . LYS A 1 92  ? 20.386  -24.868 10.098  1.00 65.66  ?  86  LYS A CD  1 
ATOM   604  C CE  . LYS A 1 92  ? 20.920  -26.243 10.340  1.00 65.43  ?  86  LYS A CE  1 
ATOM   605  N NZ  . LYS A 1 92  ? 20.754  -27.059 9.097   1.00 74.94  ?  86  LYS A NZ  1 
ATOM   606  N N   . GLU A 1 93  ? 21.662  -19.514 10.803  1.00 59.49  ?  87  GLU A N   1 
ATOM   607  C CA  . GLU A 1 93  ? 22.642  -18.453 11.062  1.00 61.81  ?  87  GLU A CA  1 
ATOM   608  C C   . GLU A 1 93  ? 22.104  -17.439 12.058  1.00 59.80  ?  87  GLU A C   1 
ATOM   609  O O   . GLU A 1 93  ? 22.799  -17.054 13.001  1.00 63.56  ?  87  GLU A O   1 
ATOM   610  C CB  . GLU A 1 93  ? 23.059  -17.749 9.765   1.00 60.80  ?  87  GLU A CB  1 
ATOM   611  C CG  . GLU A 1 93  ? 23.373  -18.718 8.637   1.00 73.23  ?  87  GLU A CG  1 
ATOM   612  C CD  . GLU A 1 93  ? 24.521  -18.269 7.748   1.00 85.61  ?  87  GLU A CD  1 
ATOM   613  O OE1 . GLU A 1 93  ? 24.922  -17.077 7.834   1.00 85.96  ?  87  GLU A OE1 1 
ATOM   614  O OE2 . GLU A 1 93  ? 25.026  -19.126 6.971   1.00 81.79  -1 87  GLU A OE2 1 
ATOM   615  N N   . LEU A 1 94  ? 20.860  -16.991 11.866  1.00 62.59  ?  88  LEU A N   1 
ATOM   616  C CA  . LEU A 1 94  ? 20.300  -15.990 12.768  1.00 55.73  ?  88  LEU A CA  1 
ATOM   617  C C   . LEU A 1 94  ? 20.157  -16.538 14.183  1.00 58.80  ?  88  LEU A C   1 
ATOM   618  O O   . LEU A 1 94  ? 20.583  -15.893 15.150  1.00 60.02  ?  88  LEU A O   1 
ATOM   619  C CB  . LEU A 1 94  ? 18.957  -15.505 12.231  1.00 61.35  ?  88  LEU A CB  1 
ATOM   620  C CG  . LEU A 1 94  ? 19.118  -14.669 10.964  1.00 60.93  ?  88  LEU A CG  1 
ATOM   621  C CD1 . LEU A 1 94  ? 17.833  -14.565 10.199  1.00 54.64  ?  88  LEU A CD1 1 
ATOM   622  C CD2 . LEU A 1 94  ? 19.654  -13.299 11.321  1.00 56.18  ?  88  LEU A CD2 1 
ATOM   623  N N   . LEU A 1 95  ? 19.546  -17.723 14.324  1.00 54.77  ?  89  LEU A N   1 
ATOM   624  C CA  . LEU A 1 95  ? 19.509  -18.417 15.611  1.00 58.95  ?  89  LEU A CA  1 
ATOM   625  C C   . LEU A 1 95  ? 20.873  -18.387 16.302  1.00 63.24  ?  89  LEU A C   1 
ATOM   626  O O   . LEU A 1 95  ? 20.992  -18.012 17.480  1.00 60.76  ?  89  LEU A O   1 
ATOM   627  C CB  . LEU A 1 95  ? 19.057  -19.868 15.400  1.00 58.72  ?  89  LEU A CB  1 
ATOM   628  C CG  . LEU A 1 95  ? 17.595  -20.147 15.037  1.00 56.75  ?  89  LEU A CG  1 
ATOM   629  C CD1 . LEU A 1 95  ? 17.371  -21.647 14.870  1.00 51.93  ?  89  LEU A CD1 1 
ATOM   630  C CD2 . LEU A 1 95  ? 16.635  -19.571 16.087  1.00 51.39  ?  89  LEU A CD2 1 
ATOM   631  N N   . ALA A 1 96  ? 21.924  -18.752 15.552  1.00 61.33  ?  90  ALA A N   1 
ATOM   632  C CA  . ALA A 1 96  ? 23.280  -18.760 16.086  1.00 61.30  ?  90  ALA A CA  1 
ATOM   633  C C   . ALA A 1 96  ? 23.714  -17.400 16.624  1.00 62.60  ?  90  ALA A C   1 
ATOM   634  O O   . ALA A 1 96  ? 24.636  -17.341 17.449  1.00 63.83  ?  90  ALA A O   1 
ATOM   635  C CB  . ALA A 1 96  ? 24.242  -19.246 15.008  1.00 61.23  ?  90  ALA A CB  1 
ATOM   636  N N   . ARG A 1 97  ? 23.077  -16.307 16.195  1.00 58.53  ?  91  ARG A N   1 
ATOM   637  C CA  . ARG A 1 97  ? 23.324  -15.009 16.810  1.00 57.23  ?  91  ARG A CA  1 
ATOM   638  C C   . ARG A 1 97  ? 22.387  -14.717 17.976  1.00 57.33  ?  91  ARG A C   1 
ATOM   639  O O   . ARG A 1 97  ? 22.412  -13.602 18.502  1.00 56.82  ?  91  ARG A O   1 
ATOM   640  C CB  . ARG A 1 97  ? 23.226  -13.899 15.764  1.00 57.80  ?  91  ARG A CB  1 
ATOM   641  C CG  . ARG A 1 97  ? 24.014  -14.178 14.497  1.00 61.02  ?  91  ARG A CG  1 
ATOM   642  C CD  . ARG A 1 97  ? 24.094  -12.913 13.635  1.00 72.30  ?  91  ARG A CD  1 
ATOM   643  N NE  . ARG A 1 97  ? 24.287  -13.196 12.213  1.00 78.26  ?  91  ARG A NE  1 
ATOM   644  C CZ  . ARG A 1 97  ? 24.604  -12.290 11.292  1.00 76.24  ?  91  ARG A CZ  1 
ATOM   645  N NH1 . ARG A 1 97  ? 24.749  -11.009 11.599  1.00 69.65  ?  91  ARG A NH1 1 
ATOM   646  N NH2 . ARG A 1 97  ? 24.778  -12.679 10.029  1.00 73.43  ?  91  ARG A NH2 1 
ATOM   647  N N   . GLY A 1 98  ? 21.590  -15.699 18.416  1.00 62.29  ?  92  GLY A N   1 
ATOM   648  C CA  . GLY A 1 98  ? 20.627  -15.474 19.479  1.00 53.76  ?  92  GLY A CA  1 
ATOM   649  C C   . GLY A 1 98  ? 19.410  -14.685 19.046  1.00 59.27  ?  92  GLY A C   1 
ATOM   650  O O   . GLY A 1 98  ? 18.700  -14.123 19.896  1.00 59.95  ?  92  GLY A O   1 
ATOM   651  N N   . ILE A 1 99  ? 19.156  -14.616 17.740  1.00 56.71  ?  93  ILE A N   1 
ATOM   652  C CA  . ILE A 1 99  ? 17.971  -13.976 17.178  1.00 58.24  ?  93  ILE A CA  1 
ATOM   653  C C   . ILE A 1 99  ? 16.899  -15.033 16.923  1.00 56.79  ?  93  ILE A C   1 
ATOM   654  O O   . ILE A 1 99  ? 17.142  -16.018 16.214  1.00 58.32  ?  93  ILE A O   1 
ATOM   655  C CB  . ILE A 1 99  ? 18.324  -13.236 15.880  1.00 58.10  ?  93  ILE A CB  1 
ATOM   656  C CG1 . ILE A 1 99  ? 19.352  -12.137 16.178  1.00 61.83  ?  93  ILE A CG1 1 
ATOM   657  C CG2 . ILE A 1 99  ? 17.072  -12.653 15.248  1.00 57.86  ?  93  ILE A CG2 1 
ATOM   658  C CD1 . ILE A 1 99  ? 20.072  -11.609 14.948  1.00 56.82  ?  93  ILE A CD1 1 
ATOM   659  N N   . HIS A 1 100 ? 15.715  -14.838 17.494  1.00 57.56  ?  94  HIS A N   1 
ATOM   660  C CA  . HIS A 1 100 ? 14.593  -15.727 17.215  1.00 56.11  ?  94  HIS A CA  1 
ATOM   661  C C   . HIS A 1 100 ? 14.243  -15.675 15.730  1.00 53.48  ?  94  HIS A C   1 
ATOM   662  O O   . HIS A 1 100 ? 14.445  -14.658 15.063  1.00 52.32  ?  94  HIS A O   1 
ATOM   663  C CB  . HIS A 1 100 ? 13.374  -15.319 18.050  1.00 53.65  ?  94  HIS A CB  1 
ATOM   664  C CG  . HIS A 1 100 ? 13.663  -15.124 19.510  1.00 55.35  ?  94  HIS A CG  1 
ATOM   665  N ND1 . HIS A 1 100 ? 14.358  -16.046 20.269  1.00 58.34  ?  94  HIS A ND1 1 
ATOM   666  C CD2 . HIS A 1 100 ? 13.334  -14.117 20.356  1.00 56.73  ?  94  HIS A CD2 1 
ATOM   667  C CE1 . HIS A 1 100 ? 14.451  -15.612 21.515  1.00 55.03  ?  94  HIS A CE1 1 
ATOM   668  N NE2 . HIS A 1 100 ? 13.837  -14.442 21.595  1.00 58.71  ?  94  HIS A NE2 1 
ATOM   669  N N   . THR A 1 101 ? 13.705  -16.777 15.199  1.00 52.62  ?  95  THR A N   1 
ATOM   670  C CA  . THR A 1 101 ? 13.308  -16.810 13.793  1.00 55.50  ?  95  THR A CA  1 
ATOM   671  C C   . THR A 1 101 ? 11.913  -17.390 13.595  1.00 56.43  ?  95  THR A C   1 
ATOM   672  O O   . THR A 1 101 ? 11.550  -18.414 14.188  1.00 58.12  ?  95  THR A O   1 
ATOM   673  C CB  . THR A 1 101 ? 14.282  -17.625 12.909  1.00 57.30  ?  95  THR A CB  1 
ATOM   674  O OG1 . THR A 1 101 ? 14.163  -19.018 13.214  1.00 60.19  ?  95  THR A OG1 1 
ATOM   675  C CG2 . THR A 1 101 ? 15.737  -17.170 13.088  1.00 57.42  ?  95  THR A CG2 1 
ATOM   676  N N   . ILE A 1 102 ? 11.153  -16.747 12.719  1.00 53.29  ?  96  ILE A N   1 
ATOM   677  C CA  . ILE A 1 102 ? 9.902   -17.283 12.205  1.00 51.54  ?  96  ILE A CA  1 
ATOM   678  C C   . ILE A 1 102 ? 10.093  -17.601 10.729  1.00 54.08  ?  96  ILE A C   1 
ATOM   679  O O   . ILE A 1 102 ? 10.737  -16.840 9.994   1.00 59.34  ?  96  ILE A O   1 
ATOM   680  C CB  . ILE A 1 102 ? 8.745   -16.288 12.404  1.00 52.15  ?  96  ILE A CB  1 
ATOM   681  C CG1 . ILE A 1 102 ? 8.861   -15.608 13.782  1.00 46.87  ?  96  ILE A CG1 1 
ATOM   682  C CG2 . ILE A 1 102 ? 7.404   -16.982 12.157  1.00 51.91  ?  96  ILE A CG2 1 
ATOM   683  C CD1 . ILE A 1 102 ? 8.452   -16.508 14.954  1.00 49.18  ?  96  ILE A CD1 1 
ATOM   684  N N   . ASP A 1 103 ? 9.556   -18.730 10.297  1.00 49.44  ?  97  ASP A N   1 
ATOM   685  C CA  . ASP A 1 103 ? 9.536   -19.058 8.886   1.00 55.05  ?  97  ASP A CA  1 
ATOM   686  C C   . ASP A 1 103 ? 8.234   -19.782 8.601   1.00 54.34  ?  97  ASP A C   1 
ATOM   687  O O   . ASP A 1 103 ? 7.502   -20.160 9.516   1.00 54.79  ?  97  ASP A O   1 
ATOM   688  C CB  . ASP A 1 103 ? 10.755  -19.901 8.490   1.00 57.63  ?  97  ASP A CB  1 
ATOM   689  C CG  . ASP A 1 103 ? 10.694  -21.320 9.046   1.00 62.98  ?  97  ASP A CG  1 
ATOM   690  O OD1 . ASP A 1 103 ? 9.876   -22.127 8.544   1.00 59.08  ?  97  ASP A OD1 1 
ATOM   691  O OD2 . ASP A 1 103 ? 11.470  -21.630 9.992   1.00 65.12  -1 97  ASP A OD2 1 
ATOM   692  N N   . SER A 1 104 ? 7.936   -19.955 7.324   1.00 51.73  ?  98  SER A N   1 
ATOM   693  C CA  . SER A 1 104 ? 6.758   -20.701 6.903   1.00 57.21  ?  98  SER A CA  1 
ATOM   694  C C   . SER A 1 104 ? 7.146   -21.781 5.899   1.00 59.21  ?  98  SER A C   1 
ATOM   695  O O   . SER A 1 104 ? 6.420   -22.057 4.935   1.00 57.80  ?  98  SER A O   1 
ATOM   696  C CB  . SER A 1 104 ? 5.694   -19.773 6.323   1.00 55.15  ?  98  SER A CB  1 
ATOM   697  O OG  . SER A 1 104 ? 6.173   -19.145 5.152   1.00 58.24  ?  98  SER A OG  1 
ATOM   698  N N   . PHE A 1 105 ? 8.327   -22.376 6.103   1.00 60.23  ?  99  PHE A N   1 
ATOM   699  C CA  . PHE A 1 105 ? 8.792   -23.574 5.403   1.00 62.95  ?  99  PHE A CA  1 
ATOM   700  C C   . PHE A 1 105 ? 7.629   -24.510 5.068   1.00 67.29  ?  99  PHE A C   1 
ATOM   701  O O   . PHE A 1 105 ? 6.857   -24.888 5.963   1.00 60.63  ?  99  PHE A O   1 
ATOM   702  C CB  . PHE A 1 105 ? 9.829   -24.275 6.279   1.00 59.07  ?  99  PHE A CB  1 
ATOM   703  C CG  . PHE A 1 105 ? 10.455  -25.474 5.656   1.00 64.99  ?  99  PHE A CG  1 
ATOM   704  C CD1 . PHE A 1 105 ? 9.863   -26.729 5.781   1.00 66.66  ?  99  PHE A CD1 1 
ATOM   705  C CD2 . PHE A 1 105 ? 11.666  -25.362 4.975   1.00 66.06  ?  99  PHE A CD2 1 
ATOM   706  C CE1 . PHE A 1 105 ? 10.458  -27.855 5.215   1.00 71.46  ?  99  PHE A CE1 1 
ATOM   707  C CE2 . PHE A 1 105 ? 12.264  -26.470 4.406   1.00 68.15  ?  99  PHE A CE2 1 
ATOM   708  C CZ  . PHE A 1 105 ? 11.659  -27.728 4.520   1.00 70.38  ?  99  PHE A CZ  1 
ATOM   709  N N   . ASP A 1 106 ? 7.480   -24.889 3.792   1.00 63.51  ?  100 ASP A N   1 
ATOM   710  C CA  . ASP A 1 106 ? 6.249   -25.540 3.358   1.00 62.63  ?  100 ASP A CA  1 
ATOM   711  C C   . ASP A 1 106 ? 6.414   -26.942 2.772   1.00 65.02  ?  100 ASP A C   1 
ATOM   712  O O   . ASP A 1 106 ? 5.464   -27.444 2.164   1.00 65.47  ?  100 ASP A O   1 
ATOM   713  C CB  . ASP A 1 106 ? 5.507   -24.646 2.356   1.00 66.27  ?  100 ASP A CB  1 
ATOM   714  C CG  . ASP A 1 106 ? 6.361   -24.255 1.157   1.00 69.87  ?  100 ASP A CG  1 
ATOM   715  O OD1 . ASP A 1 106 ? 7.533   -24.690 1.082   1.00 69.01  ?  100 ASP A OD1 1 
ATOM   716  O OD2 . ASP A 1 106 ? 5.854   -23.490 0.294   1.00 70.51  -1 100 ASP A OD2 1 
ATOM   717  N N   . ILE A 1 107 ? 7.553   -27.607 2.945   1.00 60.95  ?  101 ILE A N   1 
ATOM   718  C CA  . ILE A 1 107 ? 7.665   -29.005 2.543   1.00 67.86  ?  101 ILE A CA  1 
ATOM   719  C C   . ILE A 1 107 ? 7.288   -29.854 3.755   1.00 68.33  ?  101 ILE A C   1 
ATOM   720  O O   . ILE A 1 107 ? 8.080   -30.032 4.688   1.00 68.15  ?  101 ILE A O   1 
ATOM   721  C CB  . ILE A 1 107 ? 9.054   -29.368 2.021   1.00 70.60  ?  101 ILE A CB  1 
ATOM   722  C CG1 . ILE A 1 107 ? 9.298   -28.777 0.634   1.00 75.29  ?  101 ILE A CG1 1 
ATOM   723  C CG2 . ILE A 1 107 ? 9.133   -30.850 1.832   1.00 70.13  ?  101 ILE A CG2 1 
ATOM   724  C CD1 . ILE A 1 107 ? 10.705  -28.267 0.449   1.00 71.61  ?  101 ILE A CD1 1 
ATOM   725  N N   . HIS A 1 108 ? 6.069   -30.393 3.728   1.00 66.09  ?  102 HIS A N   1 
ATOM   726  C CA  . HIS A 1 108 ? 5.552   -31.145 4.864   1.00 62.71  ?  102 HIS A CA  1 
ATOM   727  C C   . HIS A 1 108 ? 6.485   -32.274 5.259   1.00 68.09  ?  102 HIS A C   1 
ATOM   728  O O   . HIS A 1 108 ? 6.754   -32.468 6.446   1.00 73.56  ?  102 HIS A O   1 
ATOM   729  C CB  . HIS A 1 108 ? 4.177   -31.696 4.529   1.00 60.84  ?  102 HIS A CB  1 
ATOM   730  C CG  . HIS A 1 108 ? 3.123   -30.644 4.359   1.00 66.38  ?  102 HIS A CG  1 
ATOM   731  N ND1 . HIS A 1 108 ? 2.416   -30.116 5.420   1.00 62.04  ?  102 HIS A ND1 1 
ATOM   732  C CD2 . HIS A 1 108 ? 2.635   -30.045 3.246   1.00 61.54  ?  102 HIS A CD2 1 
ATOM   733  C CE1 . HIS A 1 108 ? 1.537   -29.242 4.968   1.00 63.75  ?  102 HIS A CE1 1 
ATOM   734  N NE2 . HIS A 1 108 ? 1.648   -29.180 3.653   1.00 64.67  ?  102 HIS A NE2 1 
ATOM   735  N N   . GLN A 1 109 ? 7.018   -33.009 4.280   1.00 66.59  ?  103 GLN A N   1 
ATOM   736  C CA  . GLN A 1 109 ? 7.776   -34.211 4.602   1.00 67.47  ?  103 GLN A CA  1 
ATOM   737  C C   . GLN A 1 109 ? 9.151   -33.922 5.196   1.00 74.41  ?  103 GLN A C   1 
ATOM   738  O O   . GLN A 1 109 ? 9.813   -34.858 5.663   1.00 76.17  ?  103 GLN A O   1 
ATOM   739  C CB  . GLN A 1 109 ? 7.913   -35.096 3.355   1.00 72.36  ?  103 GLN A CB  1 
ATOM   740  C CG  . GLN A 1 109 ? 9.174   -34.883 2.520   1.00 84.08  ?  103 GLN A CG  1 
ATOM   741  C CD  . GLN A 1 109 ? 10.274  -35.916 2.808   1.00 92.40  ?  103 GLN A CD  1 
ATOM   742  O OE1 . GLN A 1 109 ? 10.022  -36.962 3.430   1.00 92.92  ?  103 GLN A OE1 1 
ATOM   743  N NE2 . GLN A 1 109 ? 11.504  -35.626 2.347   1.00 91.18  ?  103 GLN A NE2 1 
ATOM   744  N N   . GLU A 1 110 ? 9.606   -32.674 5.216   1.00 70.79  ?  104 GLU A N   1 
ATOM   745  C CA  . GLU A 1 110 ? 10.906  -32.391 5.799   1.00 67.35  ?  104 GLU A CA  1 
ATOM   746  C C   . GLU A 1 110 ? 10.807  -31.605 7.093   1.00 64.85  ?  104 GLU A C   1 
ATOM   747  O O   . GLU A 1 110 ? 11.842  -31.280 7.692   1.00 63.26  ?  104 GLU A O   1 
ATOM   748  C CB  . GLU A 1 110 ? 11.781  -31.662 4.785   1.00 71.45  ?  104 GLU A CB  1 
ATOM   749  C CG  . GLU A 1 110 ? 12.465  -32.620 3.814   1.00 78.92  ?  104 GLU A CG  1 
ATOM   750  C CD  . GLU A 1 110 ? 12.763  -31.982 2.465   1.00 86.70  ?  104 GLU A CD  1 
ATOM   751  O OE1 . GLU A 1 110 ? 12.250  -30.869 2.188   1.00 82.91  ?  104 GLU A OE1 1 
ATOM   752  O OE2 . GLU A 1 110 ? 13.517  -32.597 1.680   1.00 94.94  -1 104 GLU A OE2 1 
ATOM   753  N N   . ILE A 1 111 ? 9.588   -31.346 7.565   1.00 59.90  ?  105 ILE A N   1 
ATOM   754  C CA  . ILE A 1 111 ? 9.390   -30.502 8.739   1.00 62.13  ?  105 ILE A CA  1 
ATOM   755  C C   . ILE A 1 111 ? 10.032  -31.124 9.975   1.00 59.63  ?  105 ILE A C   1 
ATOM   756  O O   . ILE A 1 111 ? 10.764  -30.449 10.711  1.00 62.39  ?  105 ILE A O   1 
ATOM   757  C CB  . ILE A 1 111 ? 7.888   -30.225 8.943   1.00 57.82  ?  105 ILE A CB  1 
ATOM   758  C CG1 . ILE A 1 111 ? 7.430   -29.162 7.941   1.00 62.30  ?  105 ILE A CG1 1 
ATOM   759  C CG2 . ILE A 1 111 ? 7.586   -29.814 10.383  1.00 50.25  ?  105 ILE A CG2 1 
ATOM   760  C CD1 . ILE A 1 111 ? 5.919   -28.972 7.876   1.00 64.82  ?  105 ILE A CD1 1 
ATOM   761  N N   . VAL A 1 112 ? 9.768   -32.416 10.227  1.00 62.01  ?  106 VAL A N   1 
ATOM   762  C CA  . VAL A 1 112 ? 10.302  -33.069 11.429  1.00 58.90  ?  106 VAL A CA  1 
ATOM   763  C C   . VAL A 1 112 ? 11.821  -32.948 11.472  1.00 60.79  ?  106 VAL A C   1 
ATOM   764  O O   . VAL A 1 112 ? 12.403  -32.589 12.503  1.00 62.79  ?  106 VAL A O   1 
ATOM   765  C CB  . VAL A 1 112 ? 9.863   -34.543 11.501  1.00 61.91  ?  106 VAL A CB  1 
ATOM   766  C CG1 . VAL A 1 112 ? 10.664  -35.291 12.568  1.00 56.27  ?  106 VAL A CG1 1 
ATOM   767  C CG2 . VAL A 1 112 ? 8.407   -34.645 11.812  1.00 65.05  ?  106 VAL A CG2 1 
ATOM   768  N N   . GLN A 1 113 ? 12.484  -33.249 10.352  1.00 62.41  ?  107 GLN A N   1 
ATOM   769  C CA  . GLN A 1 113 ? 13.943  -33.153 10.293  1.00 64.27  ?  107 GLN A CA  1 
ATOM   770  C C   . GLN A 1 113 ? 14.411  -31.708 10.454  1.00 66.26  ?  107 GLN A C   1 
ATOM   771  O O   . GLN A 1 113 ? 15.347  -31.431 11.221  1.00 64.56  ?  107 GLN A O   1 
ATOM   772  C CB  . GLN A 1 113 ? 14.446  -33.734 8.971   1.00 64.68  ?  107 GLN A CB  1 
ATOM   773  C CG  . GLN A 1 113 ? 15.878  -33.420 8.652   1.00 70.67  ?  107 GLN A CG  1 
ATOM   774  C CD  . GLN A 1 113 ? 16.847  -34.114 9.596   1.00 73.66  ?  107 GLN A CD  1 
ATOM   775  O OE1 . GLN A 1 113 ? 16.572  -35.215 10.072  1.00 76.57  ?  107 GLN A OE1 1 
ATOM   776  N NE2 . GLN A 1 113 ? 17.982  -33.465 9.883   1.00 66.66  ?  107 GLN A NE2 1 
ATOM   777  N N   . VAL A 1 114 ? 13.770  -30.771 9.734   1.00 63.99  ?  108 VAL A N   1 
ATOM   778  C CA  . VAL A 1 114 ? 14.121  -29.358 9.874   1.00 63.23  ?  108 VAL A CA  1 
ATOM   779  C C   . VAL A 1 114 ? 13.930  -28.910 11.314  1.00 60.60  ?  108 VAL A C   1 
ATOM   780  O O   . VAL A 1 114 ? 14.776  -28.205 11.884  1.00 59.73  ?  108 VAL A O   1 
ATOM   781  C CB  . VAL A 1 114 ? 13.297  -28.488 8.908   1.00 66.14  ?  108 VAL A CB  1 
ATOM   782  C CG1 . VAL A 1 114 ? 13.529  -27.018 9.221   1.00 61.51  ?  108 VAL A CG1 1 
ATOM   783  C CG2 . VAL A 1 114 ? 13.683  -28.780 7.454   1.00 66.72  ?  108 VAL A CG2 1 
ATOM   784  N N   . ARG A 1 115 ? 12.839  -29.351 11.942  1.00 56.21  ?  109 ARG A N   1 
ATOM   785  C CA  . ARG A 1 115 ? 12.609  -28.990 13.332  1.00 59.30  ?  109 ARG A CA  1 
ATOM   786  C C   . ARG A 1 115 ? 13.745  -29.477 14.239  1.00 61.73  ?  109 ARG A C   1 
ATOM   787  O O   . ARG A 1 115 ? 14.224  -28.727 15.104  1.00 56.08  ?  109 ARG A O   1 
ATOM   788  C CB  . ARG A 1 115 ? 11.265  -29.544 13.779  1.00 60.07  ?  109 ARG A CB  1 
ATOM   789  C CG  . ARG A 1 115 ? 10.949  -29.231 15.213  1.00 59.41  ?  109 ARG A CG  1 
ATOM   790  C CD  . ARG A 1 115 ? 9.751   -30.019 15.687  1.00 62.34  ?  109 ARG A CD  1 
ATOM   791  N NE  . ARG A 1 115 ? 9.634   -29.839 17.123  1.00 70.74  ?  109 ARG A NE  1 
ATOM   792  C CZ  . ARG A 1 115 ? 9.793   -30.801 18.016  1.00 71.56  ?  109 ARG A CZ  1 
ATOM   793  N NH1 . ARG A 1 115 ? 9.959   -32.064 17.646  1.00 77.80  ?  109 ARG A NH1 1 
ATOM   794  N NH2 . ARG A 1 115 ? 9.786   -30.488 19.309  1.00 63.45  ?  109 ARG A NH2 1 
ATOM   795  N N   . HIS A 1 116 ? 14.211  -30.722 14.047  1.00 62.86  ?  110 HIS A N   1 
ATOM   796  C CA  . HIS A 1 116 ? 15.346  -31.190 14.842  1.00 61.20  ?  110 HIS A CA  1 
ATOM   797  C C   . HIS A 1 116 ? 16.573  -30.331 14.593  1.00 62.60  ?  110 HIS A C   1 
ATOM   798  O O   . HIS A 1 116 ? 17.269  -29.956 15.541  1.00 64.78  ?  110 HIS A O   1 
ATOM   799  C CB  . HIS A 1 116 ? 15.654  -32.661 14.570  1.00 60.77  ?  110 HIS A CB  1 
ATOM   800  C CG  . HIS A 1 116 ? 14.770  -33.599 15.334  1.00 71.93  ?  110 HIS A CG  1 
ATOM   801  N ND1 . HIS A 1 116 ? 14.442  -33.397 16.662  1.00 73.27  ?  110 HIS A ND1 1 
ATOM   802  C CD2 . HIS A 1 116 ? 14.104  -34.717 14.948  1.00 72.32  ?  110 HIS A CD2 1 
ATOM   803  C CE1 . HIS A 1 116 ? 13.629  -34.360 17.063  1.00 68.46  ?  110 HIS A CE1 1 
ATOM   804  N NE2 . HIS A 1 116 ? 13.406  -35.172 16.042  1.00 69.93  ?  110 HIS A NE2 1 
ATOM   805  N N   . GLU A 1 117 ? 16.834  -29.968 13.333  1.00 63.72  ?  111 GLU A N   1 
ATOM   806  C CA  . GLU A 1 117 ? 18.041  -29.195 13.036  1.00 62.73  ?  111 GLU A CA  1 
ATOM   807  C C   . GLU A 1 117 ? 17.986  -27.809 13.671  1.00 62.64  ?  111 GLU A C   1 
ATOM   808  O O   . GLU A 1 117 ? 18.961  -27.367 14.292  1.00 65.21  ?  111 GLU A O   1 
ATOM   809  C CB  . GLU A 1 117 ? 18.251  -29.103 11.528  1.00 63.42  ?  111 GLU A CB  1 
ATOM   810  C CG  . GLU A 1 117 ? 18.665  -30.424 10.929  1.00 65.72  ?  111 GLU A CG  1 
ATOM   811  C CD  . GLU A 1 117 ? 18.922  -30.332 9.452   1.00 72.82  ?  111 GLU A CD  1 
ATOM   812  O OE1 . GLU A 1 117 ? 19.238  -29.214 8.993   1.00 77.32  ?  111 GLU A OE1 1 
ATOM   813  O OE2 . GLU A 1 117 ? 18.796  -31.366 8.746   1.00 72.78  -1 111 GLU A OE2 1 
ATOM   814  N N   . LEU A 1 118 ? 16.840  -27.111 13.547  1.00 64.31  ?  112 LEU A N   1 
ATOM   815  C CA  . LEU A 1 118 ? 16.693  -25.803 14.200  1.00 59.19  ?  112 LEU A CA  1 
ATOM   816  C C   . LEU A 1 118 ? 16.706  -25.916 15.722  1.00 58.54  ?  112 LEU A C   1 
ATOM   817  O O   . LEU A 1 118 ? 17.112  -24.971 16.412  1.00 56.69  ?  112 LEU A O   1 
ATOM   818  C CB  . LEU A 1 118 ? 15.403  -25.114 13.755  1.00 55.68  ?  112 LEU A CB  1 
ATOM   819  C CG  . LEU A 1 118 ? 15.191  -24.783 12.280  1.00 56.38  ?  112 LEU A CG  1 
ATOM   820  C CD1 . LEU A 1 118 ? 14.278  -23.609 12.204  1.00 58.08  ?  112 LEU A CD1 1 
ATOM   821  C CD2 . LEU A 1 118 ? 16.496  -24.459 11.570  1.00 62.92  ?  112 LEU A CD2 1 
ATOM   822  N N   . ASP A 1 119 ? 16.251  -27.049 16.263  1.00 60.11  ?  113 ASP A N   1 
ATOM   823  C CA  . ASP A 1 119 ? 16.156  -27.185 17.713  1.00 60.25  ?  113 ASP A CA  1 
ATOM   824  C C   . ASP A 1 119 ? 17.541  -27.185 18.347  1.00 59.60  ?  113 ASP A C   1 
ATOM   825  O O   . ASP A 1 119 ? 17.756  -26.539 19.385  1.00 57.16  ?  113 ASP A O   1 
ATOM   826  C CB  . ASP A 1 119 ? 15.368  -28.453 18.058  1.00 58.93  ?  113 ASP A CB  1 
ATOM   827  C CG  . ASP A 1 119 ? 15.049  -28.574 19.547  1.00 59.87  ?  113 ASP A CG  1 
ATOM   828  O OD1 . ASP A 1 119 ? 14.391  -27.675 20.087  1.00 58.52  -1 113 ASP A OD1 1 
ATOM   829  O OD2 . ASP A 1 119 ? 15.440  -29.585 20.183  1.00 70.22  ?  113 ASP A OD2 1 
ATOM   830  N N   . GLU A 1 120 ? 18.504  -27.855 17.703  1.00 58.66  ?  114 GLU A N   1 
ATOM   831  C CA  . GLU A 1 120 ? 19.865  -27.897 18.230  1.00 61.25  ?  114 GLU A CA  1 
ATOM   832  C C   . GLU A 1 120 ? 20.434  -26.490 18.335  1.00 64.21  ?  114 GLU A C   1 
ATOM   833  O O   . GLU A 1 120 ? 20.796  -26.028 19.429  1.00 58.72  ?  114 GLU A O   1 
ATOM   834  C CB  . GLU A 1 120 ? 20.765  -28.796 17.356  1.00 61.29  ?  114 GLU A CB  1 
ATOM   835  C CG  . GLU A 1 120 ? 20.270  -30.260 17.204  1.00 71.80  ?  114 GLU A CG  1 
ATOM   836  C CD  . GLU A 1 120 ? 21.181  -31.160 16.336  1.00 81.42  ?  114 GLU A CD  1 
ATOM   837  O OE1 . GLU A 1 120 ? 22.343  -30.725 16.061  1.00 80.49  ?  114 GLU A OE1 1 
ATOM   838  O OE2 . GLU A 1 120 ? 20.746  -32.308 15.979  1.00 71.51  -1 114 GLU A OE2 1 
ATOM   839  N N   . VAL A 1 121 ? 20.477  -25.776 17.198  1.00 59.97  ?  115 VAL A N   1 
ATOM   840  C CA  . VAL A 1 121 ? 21.071  -24.441 17.158  1.00 57.12  ?  115 VAL A CA  1 
ATOM   841  C C   . VAL A 1 121 ? 20.398  -23.516 18.164  1.00 60.34  ?  115 VAL A C   1 
ATOM   842  O O   . VAL A 1 121 ? 21.070  -22.794 18.918  1.00 59.59  ?  115 VAL A O   1 
ATOM   843  C CB  . VAL A 1 121 ? 20.986  -23.867 15.733  1.00 59.21  ?  115 VAL A CB  1 
ATOM   844  C CG1 . VAL A 1 121 ? 21.737  -22.561 15.654  1.00 52.12  ?  115 VAL A CG1 1 
ATOM   845  C CG2 . VAL A 1 121 ? 21.507  -24.886 14.715  1.00 51.44  ?  115 VAL A CG2 1 
ATOM   846  N N   . ALA A 1 122 ? 19.056  -23.521 18.188  1.00 56.24  ?  116 ALA A N   1 
ATOM   847  C CA  . ALA A 1 122 ? 18.313  -22.562 19.004  1.00 57.90  ?  116 ALA A CA  1 
ATOM   848  C C   . ALA A 1 122 ? 18.555  -22.780 20.494  1.00 59.35  ?  116 ALA A C   1 
ATOM   849  O O   . ALA A 1 122 ? 18.744  -21.817 21.254  1.00 54.69  ?  116 ALA A O   1 
ATOM   850  C CB  . ALA A 1 122 ? 16.819  -22.661 18.689  1.00 57.15  ?  116 ALA A CB  1 
ATOM   851  N N   . ARG A 1 123 ? 18.482  -24.043 20.942  1.00 57.25  ?  117 ARG A N   1 
ATOM   852  C CA  . ARG A 1 123 ? 18.802  -24.357 22.332  1.00 62.00  ?  117 ARG A CA  1 
ATOM   853  C C   . ARG A 1 123 ? 20.234  -23.969 22.662  1.00 61.82  ?  117 ARG A C   1 
ATOM   854  O O   . ARG A 1 123 ? 20.509  -23.442 23.743  1.00 68.73  ?  117 ARG A O   1 
ATOM   855  C CB  . ARG A 1 123 ? 18.625  -25.844 22.598  1.00 65.36  ?  117 ARG A CB  1 
ATOM   856  C CG  . ARG A 1 123 ? 17.265  -26.345 22.393  1.00 62.46  ?  117 ARG A CG  1 
ATOM   857  C CD  . ARG A 1 123 ? 16.841  -27.047 23.632  1.00 68.38  ?  117 ARG A CD  1 
ATOM   858  N NE  . ARG A 1 123 ? 16.178  -28.293 23.287  1.00 76.02  ?  117 ARG A NE  1 
ATOM   859  C CZ  . ARG A 1 123 ? 16.105  -29.345 24.089  1.00 76.12  ?  117 ARG A CZ  1 
ATOM   860  N NH1 . ARG A 1 123 ? 16.649  -29.327 25.304  1.00 68.68  ?  117 ARG A NH1 1 
ATOM   861  N NH2 . ARG A 1 123 ? 15.461  -30.434 23.667  1.00 71.00  ?  117 ARG A NH2 1 
ATOM   862  N N   . ALA A 1 124 ? 21.160  -24.244 21.743  1.00 60.34  ?  118 ALA A N   1 
ATOM   863  C CA  . ALA A 1 124 ? 22.558  -23.915 21.970  1.00 59.78  ?  118 ALA A CA  1 
ATOM   864  C C   . ALA A 1 124 ? 22.755  -22.428 22.198  1.00 64.80  ?  118 ALA A C   1 
ATOM   865  O O   . ALA A 1 124 ? 23.667  -22.045 22.938  1.00 70.70  ?  118 ALA A O   1 
ATOM   866  C CB  . ALA A 1 124 ? 23.411  -24.391 20.794  1.00 52.61  ?  118 ALA A CB  1 
ATOM   867  N N   . HIS A 1 125 ? 21.912  -21.575 21.591  1.00 61.11  ?  119 HIS A N   1 
ATOM   868  C CA  . HIS A 1 125 ? 22.137  -20.128 21.597  1.00 65.04  ?  119 HIS A CA  1 
ATOM   869  C C   . HIS A 1 125 ? 20.994  -19.337 22.224  1.00 62.68  ?  119 HIS A C   1 
ATOM   870  O O   . HIS A 1 125 ? 20.874  -18.135 21.961  1.00 64.62  ?  119 HIS A O   1 
ATOM   871  C CB  . HIS A 1 125 ? 22.397  -19.598 20.181  1.00 60.96  ?  119 HIS A CB  1 
ATOM   872  C CG  . HIS A 1 125 ? 23.714  -20.021 19.612  1.00 66.66  ?  119 HIS A CG  1 
ATOM   873  N ND1 . HIS A 1 125 ? 23.821  -20.951 18.598  1.00 65.50  ?  119 HIS A ND1 1 
ATOM   874  C CD2 . HIS A 1 125 ? 24.981  -19.654 19.924  1.00 65.67  ?  119 HIS A CD2 1 
ATOM   875  C CE1 . HIS A 1 125 ? 25.097  -21.139 18.307  1.00 62.13  ?  119 HIS A CE1 1 
ATOM   876  N NE2 . HIS A 1 125 ? 25.821  -20.361 19.095  1.00 63.70  ?  119 HIS A NE2 1 
ATOM   877  N N   . GLN A 1 126 ? 20.162  -19.970 23.053  1.00 62.04  ?  120 GLN A N   1 
ATOM   878  C CA  . GLN A 1 126 ? 19.125  -19.257 23.816  1.00 66.91  ?  120 GLN A CA  1 
ATOM   879  C C   . GLN A 1 126 ? 18.178  -18.479 22.909  1.00 62.37  ?  120 GLN A C   1 
ATOM   880  O O   . GLN A 1 126 ? 17.786  -17.354 23.219  1.00 62.48  ?  120 GLN A O   1 
ATOM   881  C CB  . GLN A 1 126 ? 19.743  -18.319 24.856  1.00 64.36  ?  120 GLN A CB  1 
ATOM   882  C CG  . GLN A 1 126 ? 18.936  -18.160 26.148  1.00 76.03  ?  120 GLN A CG  1 
ATOM   883  C CD  . GLN A 1 126 ? 19.049  -16.745 26.749  1.00 89.71  ?  120 GLN A CD  1 
ATOM   884  O OE1 . GLN A 1 126 ? 20.121  -16.109 26.691  1.00 87.01  ?  120 GLN A OE1 1 
ATOM   885  N NE2 . GLN A 1 126 ? 17.936  -16.234 27.287  1.00 79.05  ?  120 GLN A NE2 1 
ATOM   886  N N   . ALA A 1 127 ? 17.820  -19.082 21.782  1.00 62.01  ?  121 ALA A N   1 
ATOM   887  C CA  . ALA A 1 127 ? 16.870  -18.527 20.834  1.00 59.27  ?  121 ALA A CA  1 
ATOM   888  C C   . ALA A 1 127 ? 15.695  -19.485 20.607  1.00 60.90  ?  121 ALA A C   1 
ATOM   889  O O   . ALA A 1 127 ? 15.754  -20.683 20.919  1.00 60.42  ?  121 ALA A O   1 
ATOM   890  C CB  . ALA A 1 127 ? 17.555  -18.217 19.503  1.00 56.71  ?  121 ALA A CB  1 
ATOM   891  N N   . VAL A 1 128 ? 14.613  -18.924 20.067  1.00 59.07  ?  122 VAL A N   1 
ATOM   892  C CA  . VAL A 1 128 ? 13.401  -19.649 19.719  1.00 55.44  ?  122 VAL A CA  1 
ATOM   893  C C   . VAL A 1 128 ? 13.255  -19.600 18.212  1.00 55.56  ?  122 VAL A C   1 
ATOM   894  O O   . VAL A 1 128 ? 13.408  -18.533 17.607  1.00 60.17  ?  122 VAL A O   1 
ATOM   895  C CB  . VAL A 1 128 ? 12.157  -19.028 20.382  1.00 55.81  ?  122 VAL A CB  1 
ATOM   896  C CG1 . VAL A 1 128 ? 10.903  -19.905 20.125  1.00 51.16  ?  122 VAL A CG1 1 
ATOM   897  C CG2 . VAL A 1 128 ? 12.390  -18.816 21.848  1.00 56.05  ?  122 VAL A CG2 1 
ATOM   898  N N   . ALA A 1 129 ? 12.953  -20.735 17.609  1.00 52.73  ?  123 ALA A N   1 
ATOM   899  C CA  . ALA A 1 129 ? 12.466  -20.772 16.240  1.00 54.38  ?  123 ALA A CA  1 
ATOM   900  C C   . ALA A 1 129 ? 11.057  -21.352 16.224  1.00 59.29  ?  123 ALA A C   1 
ATOM   901  O O   . ALA A 1 129 ? 10.763  -22.339 16.912  1.00 57.83  ?  123 ALA A O   1 
ATOM   902  C CB  . ALA A 1 129 ? 13.362  -21.610 15.339  1.00 48.61  ?  123 ALA A CB  1 
ATOM   903  N N   . ILE A 1 130 ? 10.190  -20.741 15.436  1.00 53.35  ?  124 ILE A N   1 
ATOM   904  C CA  . ILE A 1 130 ? 8.899   -21.310 15.112  1.00 52.86  ?  124 ILE A CA  1 
ATOM   905  C C   . ILE A 1 130 ? 8.913   -21.566 13.611  1.00 54.25  ?  124 ILE A C   1 
ATOM   906  O O   . ILE A 1 130 ? 9.222   -20.665 12.823  1.00 56.84  ?  124 ILE A O   1 
ATOM   907  C CB  . ILE A 1 130 ? 7.760   -20.372 15.548  1.00 54.88  ?  124 ILE A CB  1 
ATOM   908  C CG1 . ILE A 1 130 ? 7.720   -20.307 17.081  1.00 52.09  ?  124 ILE A CG1 1 
ATOM   909  C CG2 . ILE A 1 130 ? 6.414   -20.817 14.981  1.00 51.03  ?  124 ILE A CG2 1 
ATOM   910  C CD1 . ILE A 1 130 ? 6.839   -19.216 17.631  1.00 52.83  ?  124 ILE A CD1 1 
ATOM   911  N N   . LEU A 1 131 ? 8.632   -22.793 13.211  1.00 54.19  ?  125 LEU A N   1 
ATOM   912  C CA  . LEU A 1 131 ? 8.795   -23.137 11.808  1.00 60.22  ?  125 LEU A CA  1 
ATOM   913  C C   . LEU A 1 131 ? 7.469   -23.584 11.224  1.00 57.22  ?  125 LEU A C   1 
ATOM   914  O O   . LEU A 1 131 ? 6.572   -24.039 11.941  1.00 57.88  ?  125 LEU A O   1 
ATOM   915  C CB  . LEU A 1 131 ? 9.844   -24.237 11.603  1.00 59.42  ?  125 LEU A CB  1 
ATOM   916  C CG  . LEU A 1 131 ? 9.475   -25.664 12.040  1.00 61.21  ?  125 LEU A CG  1 
ATOM   917  C CD1 . LEU A 1 131 ? 10.177  -26.713 11.181  1.00 57.10  ?  125 LEU A CD1 1 
ATOM   918  C CD2 . LEU A 1 131 ? 9.841   -25.843 13.495  1.00 60.79  ?  125 LEU A CD2 1 
ATOM   919  N N   . ALA A 1 132 ? 7.367   -23.448 9.903   1.00 55.84  ?  126 ALA A N   1 
ATOM   920  C CA  . ALA A 1 132 ? 6.223   -23.964 9.160   1.00 60.21  ?  126 ALA A CA  1 
ATOM   921  C C   . ALA A 1 132 ? 4.949   -23.272 9.620   1.00 58.22  ?  126 ALA A C   1 
ATOM   922  O O   . ALA A 1 132 ? 3.910   -23.902 9.809   1.00 54.26  ?  126 ALA A O   1 
ATOM   923  C CB  . ALA A 1 132 ? 6.108   -25.490 9.310   1.00 61.79  ?  126 ALA A CB  1 
ATOM   924  N N   . ALA A 1 133 ? 5.054   -21.967 9.840   1.00 60.63  ?  127 ALA A N   1 
ATOM   925  C CA  . ALA A 1 133 ? 4.018   -21.188 10.486  1.00 58.36  ?  127 ALA A CA  1 
ATOM   926  C C   . ALA A 1 133 ? 3.415   -20.221 9.476   1.00 58.05  ?  127 ALA A C   1 
ATOM   927  O O   . ALA A 1 133 ? 3.562   -19.007 9.586   1.00 58.74  ?  127 ALA A O   1 
ATOM   928  C CB  . ALA A 1 133 ? 4.592   -20.468 11.688  1.00 52.74  ?  127 ALA A CB  1 
ATOM   929  N N   . GLY A 1 134 ? 2.735   -20.781 8.476   1.00 56.82  ?  128 GLY A N   1 
ATOM   930  C CA  . GLY A 1 134 ? 2.027   -19.981 7.497   1.00 54.62  ?  128 GLY A CA  1 
ATOM   931  C C   . GLY A 1 134 ? 0.562   -20.366 7.445   1.00 56.93  ?  128 GLY A C   1 
ATOM   932  O O   . GLY A 1 134 ? -0.075  -20.557 8.487   1.00 56.74  ?  128 GLY A O   1 
ATOM   933  N N   . THR A 1 135 ? 0.017   -20.506 6.234   1.00 61.06  ?  129 THR A N   1 
ATOM   934  C CA  . THR A 1 135 ? -1.339  -21.031 6.083   1.00 60.05  ?  129 THR A CA  1 
ATOM   935  C C   . THR A 1 135 ? -1.359  -22.562 6.152   1.00 64.04  ?  129 THR A C   1 
ATOM   936  O O   . THR A 1 135 ? -1.790  -23.142 7.155   1.00 67.31  ?  129 THR A O   1 
ATOM   937  C CB  . THR A 1 135 ? -1.965  -20.523 4.779   1.00 56.91  ?  129 THR A CB  1 
ATOM   938  O OG1 . THR A 1 135 ? -1.870  -19.095 4.713   1.00 53.88  ?  129 THR A OG1 1 
ATOM   939  C CG2 . THR A 1 135 ? -3.400  -20.870 4.754   1.00 58.78  ?  129 THR A CG2 1 
ATOM   940  N N   . ASP A 1 136 ? -0.912  -23.254 5.094   1.00 64.15  ?  130 ASP A N   1 
ATOM   941  C CA  . ASP A 1 136 ? -1.338  -24.656 5.095   1.00 67.92  ?  130 ASP A CA  1 
ATOM   942  C C   . ASP A 1 136 ? -0.417  -25.467 5.976   1.00 76.28  ?  130 ASP A C   1 
ATOM   943  O O   . ASP A 1 136 ? -0.905  -26.303 6.756   1.00 79.66  ?  130 ASP A O   1 
ATOM   944  C CB  . ASP A 1 136 ? -1.393  -25.307 3.714   1.00 78.63  ?  130 ASP A CB  1 
ATOM   945  C CG  . ASP A 1 136 ? -1.709  -26.834 3.796   1.00 84.16  ?  130 ASP A CG  1 
ATOM   946  O OD1 . ASP A 1 136 ? -2.182  -27.322 4.869   1.00 70.23  ?  130 ASP A OD1 1 
ATOM   947  O OD2 . ASP A 1 136 ? -1.485  -27.542 2.770   1.00 91.45  ?  130 ASP A OD2 1 
ATOM   948  N N   . PRO A 1 137 ? 0.903   -25.312 5.870   1.00 61.81  ?  131 PRO A N   1 
ATOM   949  C CA  . PRO A 1 137 ? 1.679   -25.549 7.089   1.00 60.67  ?  131 PRO A CA  1 
ATOM   950  C C   . PRO A 1 137 ? 1.501   -24.290 7.925   1.00 60.73  ?  131 PRO A C   1 
ATOM   951  O O   . PRO A 1 137 ? 1.841   -23.188 7.488   1.00 57.52  ?  131 PRO A O   1 
ATOM   952  C CB  . PRO A 1 137 ? 3.123   -25.737 6.589   1.00 59.02  ?  131 PRO A CB  1 
ATOM   953  C CG  . PRO A 1 137 ? 2.989   -25.950 5.107   1.00 63.65  ?  131 PRO A CG  1 
ATOM   954  C CD  . PRO A 1 137 ? 1.747   -25.209 4.679   1.00 60.20  ?  131 PRO A CD  1 
ATOM   955  N N   . GLY A 1 138 ? 0.869   -24.443 9.075   1.00 56.54  ?  132 GLY A N   1 
ATOM   956  C CA  . GLY A 1 138 ? 0.651   -23.327 9.953   1.00 55.46  ?  132 GLY A CA  1 
ATOM   957  C C   . GLY A 1 138 ? -0.693  -23.418 10.634  1.00 60.45  ?  132 GLY A C   1 
ATOM   958  O O   . GLY A 1 138 ? -0.931  -24.359 11.411  1.00 59.56  ?  132 GLY A O   1 
ATOM   959  N N   . THR A 1 139 ? -1.592  -22.462 10.353  1.00 52.85  ?  133 THR A N   1 
ATOM   960  C CA  . THR A 1 139 ? -2.885  -22.490 11.029  1.00 53.57  ?  133 THR A CA  1 
ATOM   961  C C   . THR A 1 139 ? -3.740  -23.663 10.560  1.00 55.96  ?  133 THR A C   1 
ATOM   962  O O   . THR A 1 139 ? -4.483  -24.247 11.360  1.00 51.05  ?  133 THR A O   1 
ATOM   963  C CB  . THR A 1 139 ? -3.626  -21.182 10.803  1.00 55.15  ?  133 THR A CB  1 
ATOM   964  O OG1 . THR A 1 139 ? -3.449  -20.802 9.440   1.00 60.78  ?  133 THR A OG1 1 
ATOM   965  C CG2 . THR A 1 139 ? -3.067  -20.091 11.714  1.00 55.19  ?  133 THR A CG2 1 
ATOM   966  N N   . CYS A 1 140 ? -3.650  -24.033 9.283   1.00 51.27  ?  134 CYS A N   1 
ATOM   967  C CA  . CYS A 1 140 ? -4.336  -25.244 8.866   1.00 58.77  ?  134 CYS A CA  1 
ATOM   968  C C   . CYS A 1 140 ? -3.858  -26.444 9.684   1.00 62.47  ?  134 CYS A C   1 
ATOM   969  O O   . CYS A 1 140 ? -4.669  -27.298 10.068  1.00 59.03  ?  134 CYS A O   1 
ATOM   970  C CB  . CYS A 1 140 ? -4.146  -25.465 7.369   1.00 62.46  ?  134 CYS A CB  1 
ATOM   971  S SG  . CYS A 1 140 ? -5.205  -24.358 6.385   1.00 64.46  ?  134 CYS A SG  1 
ATOM   972  N N   . SER A 1 141 ? -2.553  -26.498 10.001  1.00 56.75  ?  135 SER A N   1 
ATOM   973  C CA  . SER A 1 141 ? -2.045  -27.558 10.866  1.00 59.38  ?  135 SER A CA  1 
ATOM   974  C C   . SER A 1 141 ? -2.775  -27.576 12.199  1.00 58.68  ?  135 SER A C   1 
ATOM   975  O O   . SER A 1 141 ? -3.162  -28.641 12.696  1.00 54.53  ?  135 SER A O   1 
ATOM   976  C CB  . SER A 1 141 ? -0.546  -27.384 11.103  1.00 57.91  ?  135 SER A CB  1 
ATOM   977  O OG  . SER A 1 141 ? 0.152   -27.335 9.881   1.00 60.86  ?  135 SER A OG  1 
ATOM   978  N N   . MET A 1 142 ? -2.950  -26.398 12.801  1.00 52.98  ?  136 MET A N   1 
ATOM   979  C CA  . MET A 1 142 ? -3.552  -26.324 14.126  1.00 53.54  ?  136 MET A CA  1 
ATOM   980  C C   . MET A 1 142 ? -5.001  -26.810 14.095  1.00 59.14  ?  136 MET A C   1 
ATOM   981  O O   . MET A 1 142 ? -5.433  -27.604 14.945  1.00 54.78  ?  136 MET A O   1 
ATOM   982  C CB  . MET A 1 142 ? -3.500  -24.885 14.644  1.00 57.98  ?  136 MET A CB  1 
ATOM   983  C CG  . MET A 1 142 ? -2.107  -24.374 15.036  1.00 59.76  ?  136 MET A CG  1 
ATOM   984  S SD  . MET A 1 142 ? -2.072  -22.576 15.215  1.00 59.28  ?  136 MET A SD  1 
ATOM   985  C CE  . MET A 1 142 ? -2.508  -22.580 16.967  1.00 45.02  ?  136 MET A CE  1 
ATOM   986  N N   . ILE A 1 143 ? -5.770  -26.323 13.116  1.00 59.66  ?  137 ILE A N   1 
ATOM   987  C CA  . ILE A 1 143 ? -7.141  -26.781 12.924  1.00 57.05  ?  137 ILE A CA  1 
ATOM   988  C C   . ILE A 1 143 ? -7.163  -28.287 12.731  1.00 57.71  ?  137 ILE A C   1 
ATOM   989  O O   . ILE A 1 143 ? -7.813  -29.014 13.489  1.00 58.30  ?  137 ILE A O   1 
ATOM   990  C CB  . ILE A 1 143 ? -7.793  -26.058 11.734  1.00 58.93  ?  137 ILE A CB  1 
ATOM   991  C CG1 . ILE A 1 143 ? -7.658  -24.538 11.890  1.00 57.53  ?  137 ILE A CG1 1 
ATOM   992  C CG2 . ILE A 1 143 ? -9.259  -26.493 11.599  1.00 58.48  ?  137 ILE A CG2 1 
ATOM   993  C CD1 . ILE A 1 143 ? -8.432  -23.993 13.037  1.00 56.79  ?  137 ILE A CD1 1 
ATOM   994  N N   . ARG A 1 144 ? -6.432  -28.770 11.718  1.00 54.83  ?  138 ARG A N   1 
ATOM   995  C CA  . ARG A 1 144 ? -6.361  -30.203 11.432  1.00 57.50  ?  138 ARG A CA  1 
ATOM   996  C C   . ARG A 1 144 ? -6.061  -31.032 12.679  1.00 59.90  ?  138 ARG A C   1 
ATOM   997  O O   . ARG A 1 144 ? -6.519  -32.177 12.794  1.00 59.96  ?  138 ARG A O   1 
ATOM   998  C CB  . ARG A 1 144 ? -5.283  -30.459 10.383  1.00 58.36  ?  138 ARG A CB  1 
ATOM   999  C CG  . ARG A 1 144 ? -5.483  -31.662 9.530   1.00 60.02  ?  138 ARG A CG  1 
ATOM   1000 C CD  . ARG A 1 144 ? -4.776  -31.491 8.179   1.00 62.12  ?  138 ARG A CD  1 
ATOM   1001 N NE  . ARG A 1 144 ? -3.487  -30.811 8.262   1.00 60.42  ?  138 ARG A NE  1 
ATOM   1002 C CZ  . ARG A 1 144 ? -3.067  -29.895 7.396   1.00 61.83  ?  138 ARG A CZ  1 
ATOM   1003 N NH1 . ARG A 1 144 ? -3.821  -29.506 6.379   1.00 63.86  ?  138 ARG A NH1 1 
ATOM   1004 N NH2 . ARG A 1 144 ? -1.863  -29.351 7.557   1.00 61.40  ?  138 ARG A NH2 1 
ATOM   1005 N N   . SER A 1 145 ? -5.299  -30.472 13.622  1.00 57.37  ?  139 SER A N   1 
ATOM   1006 C CA  . SER A 1 145 ? -4.909  -31.229 14.808  1.00 57.83  ?  139 SER A CA  1 
ATOM   1007 C C   . SER A 1 145 ? -5.986  -31.205 15.886  1.00 54.00  ?  139 SER A C   1 
ATOM   1008 O O   . SER A 1 145 ? -6.132  -32.177 16.631  1.00 57.42  ?  139 SER A O   1 
ATOM   1009 C CB  . SER A 1 145 ? -3.585  -30.690 15.361  1.00 54.32  ?  139 SER A CB  1 
ATOM   1010 O OG  . SER A 1 145 ? -2.514  -31.093 14.529  1.00 56.70  ?  139 SER A OG  1 
ATOM   1011 N N   . ILE A 1 146 ? -6.738  -30.115 15.991  1.00 52.48  ?  140 ILE A N   1 
ATOM   1012 C CA  . ILE A 1 146 ? -7.860  -30.091 16.917  1.00 55.60  ?  140 ILE A CA  1 
ATOM   1013 C C   . ILE A 1 146 ? -8.946  -31.065 16.453  1.00 58.77  ?  140 ILE A C   1 
ATOM   1014 O O   . ILE A 1 146 ? -9.590  -31.742 17.268  1.00 58.95  ?  140 ILE A O   1 
ATOM   1015 C CB  . ILE A 1 146 ? -8.385  -28.652 17.045  1.00 54.87  ?  140 ILE A CB  1 
ATOM   1016 C CG1 . ILE A 1 146 ? -7.254  -27.731 17.511  1.00 57.18  ?  140 ILE A CG1 1 
ATOM   1017 C CG2 . ILE A 1 146 ? -9.582  -28.585 17.983  1.00 55.36  ?  140 ILE A CG2 1 
ATOM   1018 C CD1 . ILE A 1 146 ? -7.705  -26.330 17.842  1.00 60.43  ?  140 ILE A CD1 1 
ATOM   1019 N N   . LEU A 1 147 ? -9.151  -31.162 15.137  1.00 54.52  ?  141 LEU A N   1 
ATOM   1020 C CA  . LEU A 1 147 ? -10.089 -32.136 14.608  1.00 54.17  ?  141 LEU A CA  1 
ATOM   1021 C C   . LEU A 1 147 ? -9.678  -33.545 15.007  1.00 61.59  ?  141 LEU A C   1 
ATOM   1022 O O   . LEU A 1 147 ? -10.532 -34.378 15.337  1.00 59.66  ?  141 LEU A O   1 
ATOM   1023 C CB  . LEU A 1 147 ? -10.182 -32.010 13.084  1.00 54.71  ?  141 LEU A CB  1 
ATOM   1024 C CG  . LEU A 1 147 ? -10.662 -30.673 12.480  1.00 57.04  ?  141 LEU A CG  1 
ATOM   1025 C CD1 . LEU A 1 147 ? -11.016 -30.789 11.001  1.00 53.36  ?  141 LEU A CD1 1 
ATOM   1026 C CD2 . LEU A 1 147 ? -11.837 -30.116 13.237  1.00 52.42  ?  141 LEU A CD2 1 
ATOM   1027 N N   . GLU A 1 148 ? -8.369  -33.825 15.025  1.00 59.40  ?  142 GLU A N   1 
ATOM   1028 C CA  . GLU A 1 148 ? -7.948  -35.197 15.275  1.00 64.25  ?  142 GLU A CA  1 
ATOM   1029 C C   . GLU A 1 148 ? -8.303  -35.646 16.684  1.00 61.21  ?  142 GLU A C   1 
ATOM   1030 O O   . GLU A 1 148 ? -8.850  -36.736 16.867  1.00 57.69  ?  142 GLU A O   1 
ATOM   1031 C CB  . GLU A 1 148 ? -6.460  -35.360 15.013  1.00 61.86  ?  142 GLU A CB  1 
ATOM   1032 C CG  . GLU A 1 148 ? -6.233  -35.567 13.543  1.00 68.93  ?  142 GLU A CG  1 
ATOM   1033 C CD  . GLU A 1 148 ? -5.984  -37.007 13.151  1.00 65.02  ?  142 GLU A CD  1 
ATOM   1034 O OE1 . GLU A 1 148 ? -5.856  -37.868 14.045  1.00 66.71  ?  142 GLU A OE1 1 
ATOM   1035 O OE2 . GLU A 1 148 ? -5.897  -37.263 11.928  1.00 69.48  -1 142 GLU A OE2 1 
ATOM   1036 N N   . PHE A 1 149 ? -8.014  -34.826 17.694  1.00 57.51  ?  143 PHE A N   1 
ATOM   1037 C CA  . PHE A 1 149 ? -8.321  -35.296 19.035  1.00 57.68  ?  143 PHE A CA  1 
ATOM   1038 C C   . PHE A 1 149 ? -9.806  -35.199 19.361  1.00 59.44  ?  143 PHE A C   1 
ATOM   1039 O O   . PHE A 1 149 ? -10.257 -35.876 20.289  1.00 59.15  ?  143 PHE A O   1 
ATOM   1040 C CB  . PHE A 1 149 ? -7.456  -34.574 20.090  1.00 52.82  ?  143 PHE A CB  1 
ATOM   1041 C CG  . PHE A 1 149 ? -7.866  -33.138 20.433  1.00 55.24  ?  143 PHE A CG  1 
ATOM   1042 C CD1 . PHE A 1 149 ? -8.970  -32.865 21.231  1.00 55.37  ?  143 PHE A CD1 1 
ATOM   1043 C CD2 . PHE A 1 149 ? -7.056  -32.069 20.059  1.00 56.02  ?  143 PHE A CD2 1 
ATOM   1044 C CE1 . PHE A 1 149 ? -9.302  -31.552 21.595  1.00 51.10  ?  143 PHE A CE1 1 
ATOM   1045 C CE2 . PHE A 1 149 ? -7.390  -30.757 20.416  1.00 59.00  ?  143 PHE A CE2 1 
ATOM   1046 C CZ  . PHE A 1 149 ? -8.513  -30.505 21.190  1.00 54.22  ?  143 PHE A CZ  1 
ATOM   1047 N N   . MET A 1 150 ? -10.574 -34.400 18.604  1.00 58.93  ?  144 MET A N   1 
ATOM   1048 C CA  . MET A 1 150 ? -12.026 -34.353 18.783  1.00 54.69  ?  144 MET A CA  1 
ATOM   1049 C C   . MET A 1 150 ? -12.706 -35.611 18.237  1.00 56.73  ?  144 MET A C   1 
ATOM   1050 O O   . MET A 1 150 ? -13.754 -36.020 18.745  1.00 50.08  ?  144 MET A O   1 
ATOM   1051 C CB  . MET A 1 150 ? -12.600 -33.110 18.082  1.00 60.20  ?  144 MET A CB  1 
ATOM   1052 C CG  . MET A 1 150 ? -12.784 -31.861 18.972  1.00 57.45  ?  144 MET A CG  1 
ATOM   1053 S SD  . MET A 1 150 ? -13.559 -30.461 18.123  1.00 58.33  ?  144 MET A SD  1 
ATOM   1054 C CE  . MET A 1 150 ? -12.959 -30.737 16.468  1.00 59.23  ?  144 MET A CE  1 
ATOM   1055 N N   . ALA A 1 151 ? -12.143 -36.219 17.191  1.00 57.98  ?  145 ALA A N   1 
ATOM   1056 C CA  . ALA A 1 151 ? -12.717 -37.410 16.559  1.00 56.43  ?  145 ALA A CA  1 
ATOM   1057 C C   . ALA A 1 151 ? -11.584 -38.313 16.102  1.00 60.67  ?  145 ALA A C   1 
ATOM   1058 O O   . ALA A 1 151 ? -11.213 -38.323 14.918  1.00 56.27  ?  145 ALA A O   1 
ATOM   1059 C CB  . ALA A 1 151 ? -13.617 -37.038 15.381  1.00 56.98  ?  145 ALA A CB  1 
ATOM   1060 N N   . PRO A 1 152 ? -11.023 -39.115 17.018  1.00 58.00  ?  146 PRO A N   1 
ATOM   1061 C CA  . PRO A 1 152 ? -9.769  -39.815 16.708  1.00 56.02  ?  146 PRO A CA  1 
ATOM   1062 C C   . PRO A 1 152 ? -9.878  -40.849 15.597  1.00 55.76  ?  146 PRO A C   1 
ATOM   1063 O O   . PRO A 1 152 ? -8.854  -41.153 14.979  1.00 60.04  ?  146 PRO A O   1 
ATOM   1064 C CB  . PRO A 1 152 ? -9.380  -40.464 18.047  1.00 54.11  ?  146 PRO A CB  1 
ATOM   1065 C CG  . PRO A 1 152 ? -10.165 -39.785 19.090  1.00 52.00  ?  146 PRO A CG  1 
ATOM   1066 C CD  . PRO A 1 152 ? -11.414 -39.265 18.434  1.00 54.01  ?  146 PRO A CD  1 
ATOM   1067 N N   . TYR A 1 153 ? -11.056 -41.403 15.310  1.00 59.12  ?  147 TYR A N   1 
ATOM   1068 C CA  . TYR A 1 153 ? -11.198 -42.367 14.214  1.00 61.69  ?  147 TYR A CA  1 
ATOM   1069 C C   . TYR A 1 153 ? -11.881 -41.714 13.025  1.00 59.37  ?  147 TYR A C   1 
ATOM   1070 O O   . TYR A 1 153 ? -12.941 -41.102 13.175  1.00 57.53  ?  147 TYR A O   1 
ATOM   1071 C CB  . TYR A 1 153 ? -11.997 -43.616 14.611  1.00 60.16  ?  147 TYR A CB  1 
ATOM   1072 C CG  . TYR A 1 153 ? -11.380 -44.462 15.687  1.00 58.81  ?  147 TYR A CG  1 
ATOM   1073 C CD1 . TYR A 1 153 ? -10.365 -45.356 15.404  1.00 70.11  ?  147 TYR A CD1 1 
ATOM   1074 C CD2 . TYR A 1 153 ? -11.854 -44.407 16.974  1.00 62.95  ?  147 TYR A CD2 1 
ATOM   1075 C CE1 . TYR A 1 153 ? -9.820  -46.148 16.410  1.00 77.85  ?  147 TYR A CE1 1 
ATOM   1076 C CE2 . TYR A 1 153 ? -11.331 -45.185 17.976  1.00 64.53  ?  147 TYR A CE2 1 
ATOM   1077 C CZ  . TYR A 1 153 ? -10.318 -46.049 17.701  1.00 74.90  ?  147 TYR A CZ  1 
ATOM   1078 O OH  . TYR A 1 153 ? -9.820  -46.811 18.735  1.00 79.63  ?  147 TYR A OH  1 
ATOM   1079 N N   . GLY A 1 154 ? -11.295 -41.870 11.849  1.00 58.94  ?  148 GLY A N   1 
ATOM   1080 C CA  . GLY A 1 154 ? -11.873 -41.293 10.660  1.00 58.19  ?  148 GLY A CA  1 
ATOM   1081 C C   . GLY A 1 154 ? -10.776 -40.719 9.791   1.00 61.98  ?  148 GLY A C   1 
ATOM   1082 O O   . GLY A 1 154 ? -9.611  -41.083 9.935   1.00 61.18  ?  148 GLY A O   1 
ATOM   1083 N N   . ILE A 1 155 ? -11.161 -39.818 8.886   1.00 51.04  ?  149 ILE A N   1 
ATOM   1084 C CA  . ILE A 1 155 ? -10.269 -39.307 7.860   1.00 56.43  ?  149 ILE A CA  1 
ATOM   1085 C C   . ILE A 1 155 ? -10.493 -37.810 7.700   1.00 58.60  ?  149 ILE A C   1 
ATOM   1086 O O   . ILE A 1 155 ? -11.630 -37.330 7.697   1.00 63.15  ?  149 ILE A O   1 
ATOM   1087 C CB  . ILE A 1 155 ? -10.462 -40.016 6.504   1.00 56.02  ?  149 ILE A CB  1 
ATOM   1088 C CG1 . ILE A 1 155 ? -10.419 -41.535 6.656   1.00 66.53  ?  149 ILE A CG1 1 
ATOM   1089 C CG2 . ILE A 1 155 ? -9.388  -39.583 5.530   1.00 55.16  ?  149 ILE A CG2 1 
ATOM   1090 C CD1 . ILE A 1 155 ? -10.731 -42.308 5.352   1.00 67.84  ?  149 ILE A CD1 1 
ATOM   1091 N N   . THR A 1 156 ? -9.398  -37.077 7.552   1.00 59.27  ?  150 THR A N   1 
ATOM   1092 C CA  . THR A 1 156 ? -9.416  -35.664 7.235   1.00 61.29  ?  150 THR A CA  1 
ATOM   1093 C C   . THR A 1 156 ? -8.960  -35.463 5.796   1.00 63.61  ?  150 THR A C   1 
ATOM   1094 O O   . THR A 1 156 ? -8.009  -36.108 5.337   1.00 62.15  ?  150 THR A O   1 
ATOM   1095 C CB  . THR A 1 156 ? -8.507  -34.890 8.186   1.00 63.34  ?  150 THR A CB  1 
ATOM   1096 O OG1 . THR A 1 156 ? -9.043  -34.952 9.520   1.00 64.82  ?  150 THR A OG1 1 
ATOM   1097 C CG2 . THR A 1 156 ? -8.360  -33.421 7.722   1.00 64.42  ?  150 THR A CG2 1 
ATOM   1098 N N   . TYR A 1 157 ? -9.654  -34.585 5.086   1.00 59.36  ?  151 TYR A N   1 
ATOM   1099 C CA  . TYR A 1 157 ? -9.260  -34.148 3.759   1.00 60.75  ?  151 TYR A CA  1 
ATOM   1100 C C   . TYR A 1 157 ? -9.087  -32.640 3.780   1.00 61.45  ?  151 TYR A C   1 
ATOM   1101 O O   . TYR A 1 157 ? -9.972  -31.916 4.269   1.00 61.08  ?  151 TYR A O   1 
ATOM   1102 C CB  . TYR A 1 157 ? -10.311 -34.517 2.707   1.00 67.31  ?  151 TYR A CB  1 
ATOM   1103 C CG  . TYR A 1 157 ? -10.567 -35.995 2.573   1.00 71.12  ?  151 TYR A CG  1 
ATOM   1104 C CD1 . TYR A 1 157 ? -9.606  -36.837 2.011   1.00 68.28  ?  151 TYR A CD1 1 
ATOM   1105 C CD2 . TYR A 1 157 ? -11.776 -36.547 2.985   1.00 68.14  ?  151 TYR A CD2 1 
ATOM   1106 C CE1 . TYR A 1 157 ? -9.837  -38.199 1.883   1.00 72.40  ?  151 TYR A CE1 1 
ATOM   1107 C CE2 . TYR A 1 157 ? -12.019 -37.901 2.863   1.00 70.38  ?  151 TYR A CE2 1 
ATOM   1108 C CZ  . TYR A 1 157 ? -11.049 -38.727 2.312   1.00 76.20  ?  151 TYR A CZ  1 
ATOM   1109 O OH  . TYR A 1 157 ? -11.299 -40.082 2.183   1.00 77.76  ?  151 TYR A OH  1 
ATOM   1110 N N   . THR A 1 158 ? -7.972  -32.174 3.219   1.00 60.93  ?  152 THR A N   1 
ATOM   1111 C CA  . THR A 1 158 ? -7.680  -30.752 3.045   1.00 63.36  ?  152 THR A CA  1 
ATOM   1112 C C   . THR A 1 158 ? -7.675  -30.424 1.561   1.00 62.94  ?  152 THR A C   1 
ATOM   1113 O O   . THR A 1 158 ? -6.778  -30.858 0.831   1.00 60.55  ?  152 THR A O   1 
ATOM   1114 C CB  . THR A 1 158 ? -6.338  -30.374 3.655   1.00 61.38  ?  152 THR A CB  1 
ATOM   1115 O OG1 . THR A 1 158 ? -6.339  -30.691 5.056   1.00 64.33  ?  152 THR A OG1 1 
ATOM   1116 C CG2 . THR A 1 158 ? -6.105  -28.876 3.450   1.00 70.20  ?  152 THR A CG2 1 
ATOM   1117 N N   . ASN A 1 159 ? -8.648  -29.631 1.123   1.00 61.64  ?  153 ASN A N   1 
ATOM   1118 C CA  . ASN A 1 159 ? -8.791  -29.273 -0.284  1.00 64.64  ?  153 ASN A CA  1 
ATOM   1119 C C   . ASN A 1 159 ? -8.461  -27.802 -0.484  1.00 69.99  ?  153 ASN A C   1 
ATOM   1120 O O   . ASN A 1 159 ? -9.233  -26.929 -0.070  1.00 67.77  ?  153 ASN A O   1 
ATOM   1121 C CB  . ASN A 1 159 ? -10.201 -29.584 -0.745  1.00 58.31  ?  153 ASN A CB  1 
ATOM   1122 C CG  . ASN A 1 159 ? -10.542 -31.018 -0.525  1.00 66.18  ?  153 ASN A CG  1 
ATOM   1123 O OD1 . ASN A 1 159 ? -10.048 -31.885 -1.251  1.00 66.09  ?  153 ASN A OD1 1 
ATOM   1124 N ND2 . ASN A 1 159 ? -11.358 -31.299 0.496   1.00 59.28  ?  153 ASN A ND2 1 
ATOM   1125 N N   . VAL A 1 160 ? -7.319  -27.523 -1.112  1.00 72.73  ?  154 VAL A N   1 
ATOM   1126 C CA  . VAL A 1 160 ? -6.917  -26.143 -1.365  1.00 75.15  ?  154 VAL A CA  1 
ATOM   1127 C C   . VAL A 1 160 ? -7.540  -25.685 -2.685  1.00 77.81  ?  154 VAL A C   1 
ATOM   1128 O O   . VAL A 1 160 ? -7.326  -26.284 -3.753  1.00 74.40  ?  154 VAL A O   1 
ATOM   1129 C CB  . VAL A 1 160 ? -5.390  -25.980 -1.322  1.00 68.73  ?  154 VAL A CB  1 
ATOM   1130 C CG1 . VAL A 1 160 ? -4.850  -26.939 -0.298  1.00 70.69  ?  154 VAL A CG1 1 
ATOM   1131 C CG2 . VAL A 1 160 ? -4.730  -26.200 -2.659  1.00 69.77  ?  154 VAL A CG2 1 
ATOM   1132 N N   . GLY A 1 161 ? -8.401  -24.672 -2.575  1.00 82.38  ?  155 GLY A N   1 
ATOM   1133 C CA  . GLY A 1 161 ? -9.282  -24.247 -3.639  1.00 80.87  ?  155 GLY A CA  1 
ATOM   1134 C C   . GLY A 1 161 ? -8.468  -23.596 -4.728  1.00 85.37  ?  155 GLY A C   1 
ATOM   1135 O O   . GLY A 1 161 ? -7.274  -23.291 -4.540  1.00 78.29  ?  155 GLY A O   1 
ATOM   1136 N N   . PRO A 1 162 ? -9.094  -23.378 -5.889  1.00 84.30  ?  156 PRO A N   1 
ATOM   1137 C CA  . PRO A 1 162 ? -8.349  -22.862 -7.041  1.00 82.48  ?  156 PRO A CA  1 
ATOM   1138 C C   . PRO A 1 162 ? -7.482  -21.683 -6.627  1.00 77.25  ?  156 PRO A C   1 
ATOM   1139 O O   . PRO A 1 162 ? -7.944  -20.744 -5.973  1.00 79.98  ?  156 PRO A O   1 
ATOM   1140 C CB  . PRO A 1 162 ? -9.453  -22.465 -8.025  1.00 69.24  ?  156 PRO A CB  1 
ATOM   1141 C CG  . PRO A 1 162 ? -10.563 -23.363 -7.690  1.00 72.42  ?  156 PRO A CG  1 
ATOM   1142 C CD  . PRO A 1 162 ? -10.528 -23.522 -6.192  1.00 78.37  ?  156 PRO A CD  1 
ATOM   1143 N N   . GLY A 1 163 ? -6.201  -21.788 -6.938  1.00 71.45  ?  157 GLY A N   1 
ATOM   1144 C CA  . GLY A 1 163 ? -5.204  -20.838 -6.507  1.00 77.02  ?  157 GLY A CA  1 
ATOM   1145 C C   . GLY A 1 163 ? -3.846  -21.346 -6.935  1.00 84.02  ?  157 GLY A C   1 
ATOM   1146 O O   . GLY A 1 163 ? -3.640  -22.561 -7.011  1.00 85.59  ?  157 GLY A O   1 
ATOM   1147 N N   . MET A 1 164 ? -2.922  -20.431 -7.233  1.00 89.09  ?  158 MET A N   1 
ATOM   1148 C CA  . MET A 1 164 ? -1.608  -20.811 -7.743  1.00 92.45  ?  158 MET A CA  1 
ATOM   1149 C C   . MET A 1 164 ? -0.748  -21.446 -6.665  1.00 91.31  ?  158 MET A C   1 
ATOM   1150 O O   . MET A 1 164 ? -0.548  -20.872 -5.590  1.00 92.28  ?  158 MET A O   1 
ATOM   1151 C CB  . MET A 1 164 ? -0.879  -19.595 -8.323  1.00 94.08  ?  158 MET A CB  1 
ATOM   1152 C CG  . MET A 1 164 ? -0.968  -18.342 -7.462  1.00 94.18  ?  158 MET A CG  1 
ATOM   1153 S SD  . MET A 1 164 ? -0.047  -16.929 -8.102  1.00 90.45  ?  158 MET A SD  1 
ATOM   1154 C CE  . MET A 1 164 ? 1.295   -17.751 -8.958  1.00 87.56  ?  158 MET A CE  1 
ATOM   1155 N N   . SER A 1 165 ? -0.229  -22.628 -6.956  1.00 90.69  ?  159 SER A N   1 
ATOM   1156 C CA  . SER A 1 165 ? 0.939   -23.117 -6.243  1.00 103.67 ?  159 SER A CA  1 
ATOM   1157 C C   . SER A 1 165 ? 2.171   -22.565 -6.951  1.00 101.06 ?  159 SER A C   1 
ATOM   1158 O O   . SER A 1 165 ? 2.358   -22.795 -8.152  1.00 95.93  ?  159 SER A O   1 
ATOM   1159 C CB  . SER A 1 165 ? 0.967   -24.639 -6.202  1.00 100.84 ?  159 SER A CB  1 
ATOM   1160 O OG  . SER A 1 165 ? 1.371   -25.119 -7.466  1.00 102.07 ?  159 SER A OG  1 
ATOM   1161 N N   . MET A 1 166 ? 2.990   -21.813 -6.216  1.00 102.39 ?  160 MET A N   1 
ATOM   1162 C CA  . MET A 1 166 ? 4.163   -21.212 -6.834  1.00 104.14 ?  160 MET A CA  1 
ATOM   1163 C C   . MET A 1 166 ? 5.288   -22.214 -7.038  1.00 106.51 ?  160 MET A C   1 
ATOM   1164 O O   . MET A 1 166 ? 6.011   -22.119 -8.037  1.00 106.26 ?  160 MET A O   1 
ATOM   1165 C CB  . MET A 1 166 ? 4.665   -20.036 -6.004  1.00 103.98 ?  160 MET A CB  1 
ATOM   1166 C CG  . MET A 1 166 ? 5.471   -19.057 -6.825  1.00 107.51 ?  160 MET A CG  1 
ATOM   1167 S SD  . MET A 1 166 ? 4.864   -17.377 -6.622  1.00 119.52 ?  160 MET A SD  1 
ATOM   1168 C CE  . MET A 1 166 ? 4.911   -17.202 -4.841  1.00 89.21  ?  160 MET A CE  1 
ATOM   1169 N N   . GLY A 1 167 ? 5.461   -23.165 -6.116  1.00 101.15 ?  161 GLY A N   1 
ATOM   1170 C CA  . GLY A 1 167 ? 6.469   -24.190 -6.325  1.00 102.53 ?  161 GLY A CA  1 
ATOM   1171 C C   . GLY A 1 167 ? 6.295   -24.902 -7.650  1.00 105.81 ?  161 GLY A C   1 
ATOM   1172 O O   . GLY A 1 167 ? 7.273   -25.192 -8.348  1.00 106.64 ?  161 GLY A O   1 
ATOM   1173 N N   . HIS A 1 168 ? 5.042   -25.167 -8.028  1.00 106.51 ?  162 HIS A N   1 
ATOM   1174 C CA  . HIS A 1 168 ? 4.725   -25.860 -9.272  1.00 108.40 ?  162 HIS A CA  1 
ATOM   1175 C C   . HIS A 1 168 ? 4.674   -24.933 -10.474 1.00 107.41 ?  162 HIS A C   1 
ATOM   1176 O O   . HIS A 1 168 ? 4.969   -25.368 -11.596 1.00 106.89 ?  162 HIS A O   1 
ATOM   1177 C CB  . HIS A 1 168 ? 3.383   -26.586 -9.154  1.00 109.13 ?  162 HIS A CB  1 
ATOM   1178 C CG  . HIS A 1 168 ? 3.167   -27.263 -7.832  1.00 114.01 ?  162 HIS A CG  1 
ATOM   1179 N ND1 . HIS A 1 168 ? 1.911   -27.483 -7.306  1.00 108.74 ?  162 HIS A ND1 1 
ATOM   1180 C CD2 . HIS A 1 168 ? 4.043   -27.778 -6.934  1.00 118.72 ?  162 HIS A CD2 1 
ATOM   1181 C CE1 . HIS A 1 168 ? 2.022   -28.086 -6.135  1.00 111.90 ?  162 HIS A CE1 1 
ATOM   1182 N NE2 . HIS A 1 168 ? 3.306   -28.279 -5.886  1.00 118.41 ?  162 HIS A NE2 1 
ATOM   1183 N N   . SER A 1 169 ? 4.290   -23.671 -10.263 1.00 104.57 ?  163 SER A N   1 
ATOM   1184 C CA  . SER A 1 169 ? 4.293   -22.701 -11.353 1.00 103.58 ?  163 SER A CA  1 
ATOM   1185 C C   . SER A 1 169 ? 5.719   -22.410 -11.811 1.00 106.24 ?  163 SER A C   1 
ATOM   1186 O O   . SER A 1 169 ? 6.008   -22.412 -13.017 1.00 101.49 ?  163 SER A O   1 
ATOM   1187 C CB  . SER A 1 169 ? 3.578   -21.420 -10.910 1.00 96.83  ?  163 SER A CB  1 
ATOM   1188 O OG  . SER A 1 169 ? 3.577   -20.457 -11.941 1.00 93.01  ?  163 SER A OG  1 
ATOM   1189 N N   . VAL A 1 170 ? 6.631   -22.186 -10.855 1.00 104.53 ?  164 VAL A N   1 
ATOM   1190 C CA  . VAL A 1 170 ? 8.030   -21.956 -11.198 1.00 105.69 ?  164 VAL A CA  1 
ATOM   1191 C C   . VAL A 1 170 ? 8.650   -23.210 -11.808 1.00 110.09 ?  164 VAL A C   1 
ATOM   1192 O O   . VAL A 1 170 ? 9.566   -23.118 -12.639 1.00 112.05 ?  164 VAL A O   1 
ATOM   1193 C CB  . VAL A 1 170 ? 8.817   -21.465 -9.964  1.00 111.48 ?  164 VAL A CB  1 
ATOM   1194 C CG1 . VAL A 1 170 ? 8.185   -20.194 -9.382  1.00 108.84 ?  164 VAL A CG1 1 
ATOM   1195 C CG2 . VAL A 1 170 ? 8.916   -22.553 -8.905  1.00 109.40 ?  164 VAL A CG2 1 
ATOM   1196 N N   . ALA A 1 171 ? 8.161   -24.394 -11.422 1.00 107.44 ?  165 ALA A N   1 
ATOM   1197 C CA  . ALA A 1 171 ? 8.575   -25.623 -12.090 1.00 104.94 ?  165 ALA A CA  1 
ATOM   1198 C C   . ALA A 1 171 ? 8.352   -25.533 -13.594 1.00 108.78 ?  165 ALA A C   1 
ATOM   1199 O O   . ALA A 1 171 ? 9.220   -25.926 -14.383 1.00 106.06 ?  165 ALA A O   1 
ATOM   1200 C CB  . ALA A 1 171 ? 7.816   -26.814 -11.506 1.00 101.59 ?  165 ALA A CB  1 
ATOM   1201 N N   . VAL A 1 172 ? 7.202   -24.989 -14.009 1.00 112.01 ?  166 VAL A N   1 
ATOM   1202 C CA  . VAL A 1 172 ? 6.874   -24.938 -15.434 1.00 112.74 ?  166 VAL A CA  1 
ATOM   1203 C C   . VAL A 1 172 ? 7.699   -23.875 -16.152 1.00 112.69 ?  166 VAL A C   1 
ATOM   1204 O O   . VAL A 1 172 ? 8.145   -24.086 -17.291 1.00 109.16 ?  166 VAL A O   1 
ATOM   1205 C CB  . VAL A 1 172 ? 5.364   -24.736 -15.655 1.00 109.48 ?  166 VAL A CB  1 
ATOM   1206 C CG1 . VAL A 1 172 ? 4.990   -25.094 -17.107 1.00 100.58 ?  166 VAL A CG1 1 
ATOM   1207 C CG2 . VAL A 1 172 ? 4.577   -25.584 -14.682 1.00 102.66 ?  166 VAL A CG2 1 
ATOM   1208 N N   . LYS A 1 173 ? 7.910   -22.724 -15.502 1.00 111.12 ?  167 LYS A N   1 
ATOM   1209 C CA  . LYS A 1 173 ? 8.794   -21.704 -16.056 1.00 110.76 ?  167 LYS A CA  1 
ATOM   1210 C C   . LYS A 1 173 ? 10.152  -22.297 -16.413 1.00 117.13 ?  167 LYS A C   1 
ATOM   1211 O O   . LYS A 1 173 ? 10.802  -21.844 -17.365 1.00 121.22 ?  167 LYS A O   1 
ATOM   1212 C CB  . LYS A 1 173 ? 8.945   -20.543 -15.058 1.00 105.75 ?  167 LYS A CB  1 
ATOM   1213 C CG  . LYS A 1 173 ? 7.742   -19.577 -14.991 1.00 94.24  ?  167 LYS A CG  1 
ATOM   1214 C CD  . LYS A 1 173 ? 7.912   -18.489 -13.923 1.00 88.53  ?  167 LYS A CD  1 
ATOM   1215 C CE  . LYS A 1 173 ? 6.659   -18.312 -13.077 1.00 92.78  ?  167 LYS A CE  1 
ATOM   1216 N NZ  . LYS A 1 173 ? 6.844   -17.347 -11.955 1.00 94.77  ?  167 LYS A NZ  1 
ATOM   1217 N N   . ALA A 1 174 ? 10.571  -23.345 -15.698 1.00 114.14 ?  168 ALA A N   1 
ATOM   1218 C CA  . ALA A 1 174 ? 11.898  -23.911 -15.900 1.00 117.86 ?  168 ALA A CA  1 
ATOM   1219 C C   . ALA A 1 174 ? 12.018  -24.731 -17.186 1.00 117.15 ?  168 ALA A C   1 
ATOM   1220 O O   . ALA A 1 174 ? 13.110  -24.791 -17.763 1.00 117.40 ?  168 ALA A O   1 
ATOM   1221 C CB  . ALA A 1 174 ? 12.282  -24.770 -14.693 1.00 115.82 ?  168 ALA A CB  1 
ATOM   1222 N N   . ILE A 1 175 ? 10.938  -25.369 -17.658 1.00 115.25 ?  169 ILE A N   1 
ATOM   1223 C CA  . ILE A 1 175 ? 11.074  -26.283 -18.796 1.00 117.78 ?  169 ILE A CA  1 
ATOM   1224 C C   . ILE A 1 175 ? 11.341  -25.515 -20.088 1.00 118.29 ?  169 ILE A C   1 
ATOM   1225 O O   . ILE A 1 175 ? 11.161  -24.292 -20.160 1.00 118.14 ?  169 ILE A O   1 
ATOM   1226 C CB  . ILE A 1 175 ? 9.866   -27.243 -18.954 1.00 114.96 ?  169 ILE A CB  1 
ATOM   1227 C CG1 . ILE A 1 175 ? 9.457   -27.844 -17.626 1.00 114.71 ?  169 ILE A CG1 1 
ATOM   1228 C CG2 . ILE A 1 175 ? 10.174  -28.439 -19.849 1.00 119.28 ?  169 ILE A CG2 1 
ATOM   1229 C CD1 . ILE A 1 175 ? 8.304   -27.213 -17.076 1.00 112.65 ?  169 ILE A CD1 1 
ATOM   1230 N N   . GLU A 1 176 ? 11.798  -26.243 -21.106 1.00 116.99 ?  170 GLU A N   1 
ATOM   1231 C CA  . GLU A 1 176 ? 12.256  -25.665 -22.357 1.00 118.61 ?  170 GLU A CA  1 
ATOM   1232 C C   . GLU A 1 176 ? 11.078  -25.285 -23.245 1.00 113.43 ?  170 GLU A C   1 
ATOM   1233 O O   . GLU A 1 176 ? 10.050  -25.970 -23.272 1.00 111.10 ?  170 GLU A O   1 
ATOM   1234 C CB  . GLU A 1 176 ? 13.169  -26.660 -23.077 1.00 119.72 ?  170 GLU A CB  1 
ATOM   1235 C CG  . GLU A 1 176 ? 14.585  -26.714 -22.515 1.00 118.32 ?  170 GLU A CG  1 
ATOM   1236 C CD  . GLU A 1 176 ? 15.635  -26.927 -23.593 1.00 121.61 ?  170 GLU A CD  1 
ATOM   1237 O OE1 . GLU A 1 176 ? 15.250  -27.109 -24.769 1.00 118.89 ?  170 GLU A OE1 1 
ATOM   1238 O OE2 . GLU A 1 176 ? 16.844  -26.929 -23.265 1.00 122.27 ?  170 GLU A OE2 1 
ATOM   1239 N N   . GLY A 1 177 ? 11.243  -24.188 -23.981 1.00 113.24 ?  171 GLY A N   1 
ATOM   1240 C CA  . GLY A 1 177 ? 10.187  -23.635 -24.797 1.00 112.51 ?  171 GLY A CA  1 
ATOM   1241 C C   . GLY A 1 177 ? 9.083   -23.051 -23.944 1.00 113.32 ?  171 GLY A C   1 
ATOM   1242 O O   . GLY A 1 177 ? 7.907   -23.296 -24.208 1.00 113.71 ?  171 GLY A O   1 
ATOM   1243 N N   . VAL A 1 178 ? 9.440   -22.296 -22.904 1.00 112.46 ?  172 VAL A N   1 
ATOM   1244 C CA  . VAL A 1 178 ? 8.459   -21.752 -21.967 1.00 109.72 ?  172 VAL A CA  1 
ATOM   1245 C C   . VAL A 1 178 ? 8.845   -20.314 -21.634 1.00 108.72 ?  172 VAL A C   1 
ATOM   1246 O O   . VAL A 1 178 ? 9.676   -20.078 -20.747 1.00 108.36 ?  172 VAL A O   1 
ATOM   1247 C CB  . VAL A 1 178 ? 8.366   -22.626 -20.691 1.00 113.10 ?  172 VAL A CB  1 
ATOM   1248 C CG1 . VAL A 1 178 ? 7.714   -21.876 -19.533 1.00 107.60 ?  172 VAL A CG1 1 
ATOM   1249 C CG2 . VAL A 1 178 ? 7.588   -23.913 -20.961 1.00 110.17 ?  172 VAL A CG2 1 
ATOM   1250 N N   . LYS A 1 179 ? 8.270   -19.337 -22.348 1.00 105.23 ?  173 LYS A N   1 
ATOM   1251 C CA  . LYS A 1 179 ? 8.540   -17.942 -22.000 1.00 100.19 ?  173 LYS A CA  1 
ATOM   1252 C C   . LYS A 1 179 ? 8.028   -17.619 -20.604 1.00 97.71  ?  173 LYS A C   1 
ATOM   1253 O O   . LYS A 1 179 ? 8.807   -17.278 -19.708 1.00 97.61  ?  173 LYS A O   1 
ATOM   1254 C CB  . LYS A 1 179 ? 7.948   -16.984 -23.036 1.00 97.03  ?  173 LYS A CB  1 
ATOM   1255 C CG  . LYS A 1 179 ? 8.526   -17.150 -24.427 1.00 106.57 ?  173 LYS A CG  1 
ATOM   1256 C CD  . LYS A 1 179 ? 7.662   -18.008 -25.291 1.00 104.31 ?  173 LYS A CD  1 
ATOM   1257 C CE  . LYS A 1 179 ? 8.248   -18.268 -26.695 1.00 106.10 ?  173 LYS A CE  1 
ATOM   1258 N NZ  . LYS A 1 179 ? 9.484   -19.120 -26.684 1.00 96.35  ?  173 LYS A NZ  1 
ATOM   1259 N N   . ASP A 1 180 ? 6.717   -17.729 -20.398 1.00 98.06  ?  174 ASP A N   1 
ATOM   1260 C CA  . ASP A 1 180 ? 6.145   -17.592 -19.066 1.00 90.31  ?  174 ASP A CA  1 
ATOM   1261 C C   . ASP A 1 180 ? 5.069   -18.645 -18.853 1.00 86.10  ?  174 ASP A C   1 
ATOM   1262 O O   . ASP A 1 180 ? 4.421   -19.094 -19.805 1.00 86.44  ?  174 ASP A O   1 
ATOM   1263 C CB  . ASP A 1 180 ? 5.542   -16.212 -18.823 1.00 80.76  ?  174 ASP A CB  1 
ATOM   1264 C CG  . ASP A 1 180 ? 5.723   -15.760 -17.401 1.00 86.48  ?  174 ASP A CG  1 
ATOM   1265 O OD1 . ASP A 1 180 ? 6.209   -16.578 -16.582 1.00 89.73  -1 174 ASP A OD1 1 
ATOM   1266 O OD2 . ASP A 1 180 ? 5.400   -14.589 -17.102 1.00 92.14  ?  174 ASP A OD2 1 
ATOM   1267 N N   . ALA A 1 181 ? 4.871   -19.029 -17.590 1.00 78.50  ?  175 ALA A N   1 
ATOM   1268 C CA  . ALA A 1 181 ? 3.847   -20.012 -17.265 1.00 82.39  ?  175 ALA A CA  1 
ATOM   1269 C C   . ALA A 1 181 ? 3.201   -19.702 -15.918 1.00 80.26  ?  175 ALA A C   1 
ATOM   1270 O O   . ALA A 1 181 ? 3.825   -19.119 -15.022 1.00 78.27  ?  175 ALA A O   1 
ATOM   1271 C CB  . ALA A 1 181 ? 4.416   -21.443 -17.258 1.00 86.60  ?  175 ALA A CB  1 
ATOM   1272 N N   . LEU A 1 182 ? 1.921   -20.081 -15.808 1.00 76.03  ?  176 LEU A N   1 
ATOM   1273 C CA  . LEU A 1 182 ? 1.158   -20.079 -14.564 1.00 72.43  ?  176 LEU A CA  1 
ATOM   1274 C C   . LEU A 1 182 ? 0.504   -21.452 -14.412 1.00 76.84  ?  176 LEU A C   1 
ATOM   1275 O O   . LEU A 1 182 ? -0.208  -21.913 -15.316 1.00 68.31  ?  176 LEU A O   1 
ATOM   1276 C CB  . LEU A 1 182 ? 0.089   -18.969 -14.549 1.00 69.46  ?  176 LEU A CB  1 
ATOM   1277 C CG  . LEU A 1 182 ? -0.871  -18.982 -13.346 1.00 69.54  ?  176 LEU A CG  1 
ATOM   1278 C CD1 . LEU A 1 182 ? -0.113  -18.919 -12.037 1.00 75.22  ?  176 LEU A CD1 1 
ATOM   1279 C CD2 . LEU A 1 182 ? -1.963  -17.901 -13.407 1.00 63.72  ?  176 LEU A CD2 1 
ATOM   1280 N N   . ALA A 1 183 ? 0.756   -22.105 -13.274 1.00 78.78  ?  177 ALA A N   1 
ATOM   1281 C CA  . ALA A 1 183 ? 0.289   -23.462 -13.009 1.00 79.48  ?  177 ALA A CA  1 
ATOM   1282 C C   . ALA A 1 183 ? -0.503  -23.467 -11.712 1.00 80.81  ?  177 ALA A C   1 
ATOM   1283 O O   . ALA A 1 183 ? 0.038   -23.142 -10.651 1.00 87.84  ?  177 ALA A O   1 
ATOM   1284 C CB  . ALA A 1 183 ? 1.462   -24.442 -12.931 1.00 82.93  ?  177 ALA A CB  1 
ATOM   1285 N N   . LEU A 1 184 ? -1.776  -23.834 -11.799 1.00 78.39  ?  178 LEU A N   1 
ATOM   1286 C CA  . LEU A 1 184 ? -2.671  -23.834 -10.652 1.00 80.73  ?  178 LEU A CA  1 
ATOM   1287 C C   . LEU A 1 184 ? -2.897  -25.248 -10.136 1.00 83.82  ?  178 LEU A C   1 
ATOM   1288 O O   . LEU A 1 184 ? -2.904  -26.223 -10.900 1.00 80.72  ?  178 LEU A O   1 
ATOM   1289 C CB  . LEU A 1 184 ? -4.016  -23.215 -11.015 1.00 76.41  ?  178 LEU A CB  1 
ATOM   1290 C CG  . LEU A 1 184 ? -3.897  -21.930 -11.830 1.00 80.23  ?  178 LEU A CG  1 
ATOM   1291 C CD1 . LEU A 1 184 ? -5.261  -21.501 -12.330 1.00 72.20  ?  178 LEU A CD1 1 
ATOM   1292 C CD2 . LEU A 1 184 ? -3.249  -20.836 -10.991 1.00 78.55  ?  178 LEU A CD2 1 
ATOM   1293 N N   . THR A 1 185 ? -3.072  -25.349 -8.821  1.00 82.56  ?  179 THR A N   1 
ATOM   1294 C CA  . THR A 1 185 ? -3.602  -26.550 -8.206  1.00 82.99  ?  179 THR A CA  1 
ATOM   1295 C C   . THR A 1 185 ? -5.073  -26.304 -7.903  1.00 80.98  ?  179 THR A C   1 
ATOM   1296 O O   . THR A 1 185 ? -5.436  -25.260 -7.355  1.00 80.11  ?  179 THR A O   1 
ATOM   1297 C CB  . THR A 1 185 ? -2.845  -26.928 -6.938  1.00 86.87  ?  179 THR A CB  1 
ATOM   1298 O OG1 . THR A 1 185 ? -2.720  -25.780 -6.098  1.00 88.35  ?  179 THR A OG1 1 
ATOM   1299 C CG2 . THR A 1 185 ? -1.464  -27.477 -7.284  1.00 83.58  ?  179 THR A CG2 1 
ATOM   1300 N N   . ILE A 1 186 ? -5.909  -27.260 -8.294  1.00 79.03  ?  180 ILE A N   1 
ATOM   1301 C CA  . ILE A 1 186 ? -7.360  -27.143 -8.256  1.00 68.43  ?  180 ILE A CA  1 
ATOM   1302 C C   . ILE A 1 186 ? -7.876  -28.346 -7.483  1.00 73.39  ?  180 ILE A C   1 
ATOM   1303 O O   . ILE A 1 186 ? -7.559  -29.480 -7.849  1.00 73.05  ?  180 ILE A O   1 
ATOM   1304 C CB  . ILE A 1 186 ? -7.989  -27.117 -9.662  1.00 72.66  ?  180 ILE A CB  1 
ATOM   1305 C CG1 . ILE A 1 186 ? -7.572  -25.882 -10.457 1.00 77.84  ?  180 ILE A CG1 1 
ATOM   1306 C CG2 . ILE A 1 186 ? -9.488  -27.259 -9.607  1.00 71.60  ?  180 ILE A CG2 1 
ATOM   1307 C CD1 . ILE A 1 186 ? -6.171  -25.986 -11.045 1.00 78.25  ?  180 ILE A CD1 1 
ATOM   1308 N N   . PRO A 1 187 ? -8.685  -28.158 -6.442  1.00 75.75  ?  181 PRO A N   1 
ATOM   1309 C CA  . PRO A 1 187 ? -9.215  -29.317 -5.716  1.00 66.46  ?  181 PRO A CA  1 
ATOM   1310 C C   . PRO A 1 187 ? -10.216 -30.061 -6.570  1.00 72.09  ?  181 PRO A C   1 
ATOM   1311 O O   . PRO A 1 187 ? -11.048 -29.461 -7.253  1.00 75.46  ?  181 PRO A O   1 
ATOM   1312 C CB  . PRO A 1 187 ? -9.900  -28.702 -4.497  1.00 68.76  ?  181 PRO A CB  1 
ATOM   1313 C CG  . PRO A 1 187 ? -10.376 -27.354 -5.013  1.00 78.93  ?  181 PRO A CG  1 
ATOM   1314 C CD  . PRO A 1 187 ? -9.407  -26.918 -6.107  1.00 75.92  ?  181 PRO A CD  1 
ATOM   1315 N N   . ILE A 1 188 ? -10.134 -31.384 -6.537  1.00 71.17  ?  182 ILE A N   1 
ATOM   1316 C CA  . ILE A 1 188 ? -11.154 -32.171 -7.205  1.00 71.26  ?  182 ILE A CA  1 
ATOM   1317 C C   . ILE A 1 188 ? -11.701 -33.183 -6.208  1.00 71.47  ?  182 ILE A C   1 
ATOM   1318 O O   . ILE A 1 188 ? -12.138 -34.275 -6.586  1.00 68.89  ?  182 ILE A O   1 
ATOM   1319 C CB  . ILE A 1 188 ? -10.591 -32.826 -8.476  1.00 72.24  ?  182 ILE A CB  1 
ATOM   1320 C CG1 . ILE A 1 188 ? -9.285  -33.549 -8.165  1.00 72.12  ?  182 ILE A CG1 1 
ATOM   1321 C CG2 . ILE A 1 188 ? -10.374 -31.770 -9.554  1.00 72.76  ?  182 ILE A CG2 1 
ATOM   1322 C CD1 . ILE A 1 188 ? -9.181  -34.901 -8.868  1.00 73.95  ?  182 ILE A CD1 1 
ATOM   1323 N N   . GLY A 1 189 ? -11.670 -32.824 -4.930  1.00 68.00  ?  183 GLY A N   1 
ATOM   1324 C CA  . GLY A 1 189 ? -12.302 -33.610 -3.895  1.00 68.20  ?  183 GLY A CA  1 
ATOM   1325 C C   . GLY A 1 189 ? -11.325 -34.554 -3.222  1.00 73.96  ?  183 GLY A C   1 
ATOM   1326 O O   . GLY A 1 189 ? -10.223 -34.816 -3.714  1.00 74.52  ?  183 GLY A O   1 
ATOM   1327 N N   . THR A 1 190 ? -11.737 -35.046 -2.043  1.00 73.37  ?  184 THR A N   1 
ATOM   1328 C CA  . THR A 1 190 ? -11.054 -36.139 -1.328  1.00 72.22  ?  184 THR A CA  1 
ATOM   1329 C C   . THR A 1 190 ? -9.553  -35.908 -1.205  1.00 72.61  ?  184 THR A C   1 
ATOM   1330 O O   . THR A 1 190 ? -8.760  -36.855 -1.219  1.00 75.38  ?  184 THR A O   1 
ATOM   1331 C CB  . THR A 1 190 ? -11.314 -37.504 -1.986  1.00 71.25  ?  184 THR A CB  1 
ATOM   1332 O OG1 . THR A 1 190 ? -12.362 -37.394 -2.952  1.00 71.39  ?  184 THR A OG1 1 
ATOM   1333 C CG2 . THR A 1 190 ? -11.726 -38.508 -0.959  1.00 72.39  ?  184 THR A CG2 1 
ATOM   1334 N N   . GLY A 1 191 ? -9.142  -34.654 -1.074  1.00 64.58  ?  185 GLY A N   1 
ATOM   1335 C CA  . GLY A 1 191 ? -7.735  -34.364 -0.927  1.00 66.30  ?  185 GLY A CA  1 
ATOM   1336 C C   . GLY A 1 191 ? -6.940  -34.443 -2.206  1.00 66.53  ?  185 GLY A C   1 
ATOM   1337 O O   . GLY A 1 191 ? -5.756  -34.099 -2.194  1.00 63.59  ?  185 GLY A O   1 
ATOM   1338 N N   . LEU A 1 192 ? -7.557  -34.878 -3.303  1.00 66.71  ?  186 LEU A N   1 
ATOM   1339 C CA  . LEU A 1 192 ? -6.973  -34.938 -4.632  1.00 68.34  ?  186 LEU A CA  1 
ATOM   1340 C C   . LEU A 1 192 ? -7.031  -33.579 -5.332  1.00 71.45  ?  186 LEU A C   1 
ATOM   1341 O O   . LEU A 1 192 ? -7.827  -32.696 -4.985  1.00 71.31  ?  186 LEU A O   1 
ATOM   1342 C CB  . LEU A 1 192 ? -7.707  -35.983 -5.469  1.00 67.41  ?  186 LEU A CB  1 
ATOM   1343 C CG  . LEU A 1 192 ? -7.673  -37.336 -4.765  1.00 71.85  ?  186 LEU A CG  1 
ATOM   1344 C CD1 . LEU A 1 192 ? -8.571  -38.307 -5.459  1.00 70.31  ?  186 LEU A CD1 1 
ATOM   1345 C CD2 . LEU A 1 192 ? -6.240  -37.847 -4.748  1.00 63.47  ?  186 LEU A CD2 1 
ATOM   1346 N N   . HIS A 1 193 ? -6.192  -33.430 -6.357  1.00 68.54  ?  187 HIS A N   1 
ATOM   1347 C CA  . HIS A 1 193 ? -6.018  -32.132 -6.988  1.00 71.82  ?  187 HIS A CA  1 
ATOM   1348 C C   . HIS A 1 193 ? -5.698  -32.311 -8.463  1.00 67.68  ?  187 HIS A C   1 
ATOM   1349 O O   . HIS A 1 193 ? -4.954  -33.211 -8.838  1.00 65.96  ?  187 HIS A O   1 
ATOM   1350 C CB  . HIS A 1 193 ? -4.926  -31.328 -6.251  1.00 69.10  ?  187 HIS A CB  1 
ATOM   1351 C CG  . HIS A 1 193 ? -5.314  -30.961 -4.843  1.00 77.35  ?  187 HIS A CG  1 
ATOM   1352 N ND1 . HIS A 1 193 ? -4.946  -31.717 -3.745  1.00 77.60  ?  187 HIS A ND1 1 
ATOM   1353 C CD2 . HIS A 1 193 ? -6.079  -29.946 -4.358  1.00 75.84  ?  187 HIS A CD2 1 
ATOM   1354 C CE1 . HIS A 1 193 ? -5.459  -31.179 -2.648  1.00 77.86  ?  187 HIS A CE1 1 
ATOM   1355 N NE2 . HIS A 1 193 ? -6.145  -30.099 -2.990  1.00 72.43  ?  187 HIS A NE2 1 
ATOM   1356 N N   . ARG A 1 194 ? -6.295  -31.466 -9.293  1.00 73.65  ?  188 ARG A N   1 
ATOM   1357 C CA  . ARG A 1 194 ? -5.940  -31.357 -10.699 1.00 74.79  ?  188 ARG A CA  1 
ATOM   1358 C C   . ARG A 1 194 ? -5.059  -30.123 -10.912 1.00 71.85  ?  188 ARG A C   1 
ATOM   1359 O O   . ARG A 1 194 ? -4.960  -29.243 -10.055 1.00 70.98  ?  188 ARG A O   1 
ATOM   1360 C CB  . ARG A 1 194 ? -7.211  -31.328 -11.557 1.00 74.91  ?  188 ARG A CB  1 
ATOM   1361 C CG  . ARG A 1 194 ? -7.382  -30.165 -12.495 1.00 76.24  ?  188 ARG A CG  1 
ATOM   1362 C CD  . ARG A 1 194 ? -8.579  -30.409 -13.401 1.00 73.92  ?  188 ARG A CD  1 
ATOM   1363 N NE  . ARG A 1 194 ? -9.816  -29.903 -12.828 1.00 74.10  ?  188 ARG A NE  1 
ATOM   1364 C CZ  . ARG A 1 194 ? -10.942 -30.601 -12.728 1.00 77.34  ?  188 ARG A CZ  1 
ATOM   1365 N NH1 . ARG A 1 194 ? -11.014 -31.858 -13.130 1.00 80.59  ?  188 ARG A NH1 1 
ATOM   1366 N NH2 . ARG A 1 194 ? -12.027 -30.016 -12.227 1.00 73.93  ?  188 ARG A NH2 1 
ATOM   1367 N N   . ARG A 1 195 ? -4.350  -30.108 -12.034 1.00 75.06  ?  189 ARG A N   1 
ATOM   1368 C CA  . ARG A 1 195 ? -3.366  -29.073 -12.322 1.00 78.34  ?  189 ARG A CA  1 
ATOM   1369 C C   . ARG A 1 195 ? -3.708  -28.371 -13.623 1.00 78.31  ?  189 ARG A C   1 
ATOM   1370 O O   . ARG A 1 195 ? -3.911  -29.026 -14.654 1.00 77.13  ?  189 ARG A O   1 
ATOM   1371 C CB  . ARG A 1 195 ? -1.976  -29.663 -12.414 1.00 75.16  ?  189 ARG A CB  1 
ATOM   1372 C CG  . ARG A 1 195 ? -1.481  -30.134 -11.101 1.00 87.76  ?  189 ARG A CG  1 
ATOM   1373 C CD  . ARG A 1 195 ? -0.013  -29.899 -11.006 1.00 102.73 ?  189 ARG A CD  1 
ATOM   1374 N NE  . ARG A 1 195 ? 0.496   -30.204 -9.680  1.00 106.31 ?  189 ARG A NE  1 
ATOM   1375 C CZ  . ARG A 1 195 ? 1.731   -29.935 -9.292  1.00 109.48 ?  189 ARG A CZ  1 
ATOM   1376 N NH1 . ARG A 1 195 ? 2.588   -29.340 -10.100 1.00 111.40 ?  189 ARG A NH1 1 
ATOM   1377 N NH2 . ARG A 1 195 ? 2.125   -30.307 -8.080  1.00 115.78 ?  189 ARG A NH2 1 
ATOM   1378 N N   . MET A 1 196 ? -3.765  -27.045 -13.571 1.00 72.57  ?  190 MET A N   1 
ATOM   1379 C CA  . MET A 1 196 ? -4.098  -26.225 -14.727 1.00 76.08  ?  190 MET A CA  1 
ATOM   1380 C C   . MET A 1 196 ? -2.894  -25.372 -15.070 1.00 74.33  ?  190 MET A C   1 
ATOM   1381 O O   . MET A 1 196 ? -2.459  -24.555 -14.255 1.00 71.76  ?  190 MET A O   1 
ATOM   1382 C CB  . MET A 1 196 ? -5.316  -25.341 -14.459 1.00 76.80  ?  190 MET A CB  1 
ATOM   1383 C CG  . MET A 1 196 ? -6.655  -26.060 -14.559 1.00 83.03  ?  190 MET A CG  1 
ATOM   1384 S SD  . MET A 1 196 ? -7.229  -26.249 -16.267 1.00 100.27 ?  190 MET A SD  1 
ATOM   1385 C CE  . MET A 1 196 ? -6.236  -25.009 -17.160 1.00 78.50  ?  190 MET A CE  1 
ATOM   1386 N N   . VAL A 1 197 ? -2.359  -25.571 -16.263 1.00 70.69  ?  191 VAL A N   1 
ATOM   1387 C CA  . VAL A 1 197 ? -1.118  -24.950 -16.684 1.00 72.87  ?  191 VAL A CA  1 
ATOM   1388 C C   . VAL A 1 197 ? -1.448  -24.004 -17.827 1.00 72.35  ?  191 VAL A C   1 
ATOM   1389 O O   . VAL A 1 197 ? -1.984  -24.425 -18.860 1.00 71.30  ?  191 VAL A O   1 
ATOM   1390 C CB  . VAL A 1 197 ? -0.077  -26.007 -17.093 1.00 78.04  ?  191 VAL A CB  1 
ATOM   1391 C CG1 . VAL A 1 197 ? 1.209   -25.347 -17.575 1.00 76.97  ?  191 VAL A CG1 1 
ATOM   1392 C CG2 . VAL A 1 197 ? 0.213   -26.930 -15.922 1.00 74.84  ?  191 VAL A CG2 1 
ATOM   1393 N N   . TYR A 1 198 ? -1.163  -22.722 -17.624 1.00 66.56  ?  192 TYR A N   1 
ATOM   1394 C CA  . TYR A 1 198 ? -1.328  -21.698 -18.643 1.00 72.05  ?  192 TYR A CA  1 
ATOM   1395 C C   . TYR A 1 198 ? 0.063   -21.279 -19.089 1.00 78.42  ?  192 TYR A C   1 
ATOM   1396 O O   . TYR A 1 198 ? 0.878   -20.849 -18.261 1.00 75.56  ?  192 TYR A O   1 
ATOM   1397 C CB  . TYR A 1 198 ? -2.116  -20.497 -18.113 1.00 71.99  ?  192 TYR A CB  1 
ATOM   1398 C CG  . TYR A 1 198 ? -3.513  -20.838 -17.668 1.00 69.06  ?  192 TYR A CG  1 
ATOM   1399 C CD1 . TYR A 1 198 ? -4.571  -20.849 -18.578 1.00 73.25  ?  192 TYR A CD1 1 
ATOM   1400 C CD2 . TYR A 1 198 ? -3.776  -21.156 -16.348 1.00 61.09  ?  192 TYR A CD2 1 
ATOM   1401 C CE1 . TYR A 1 198 ? -5.844  -21.172 -18.183 1.00 65.29  ?  192 TYR A CE1 1 
ATOM   1402 C CE2 . TYR A 1 198 ? -5.044  -21.473 -15.940 1.00 68.24  ?  192 TYR A CE2 1 
ATOM   1403 C CZ  . TYR A 1 198 ? -6.075  -21.479 -16.860 1.00 67.09  ?  192 TYR A CZ  1 
ATOM   1404 O OH  . TYR A 1 198 ? -7.337  -21.816 -16.445 1.00 77.43  ?  192 TYR A OH  1 
ATOM   1405 N N   . VAL A 1 199 ? 0.345   -21.420 -20.381 1.00 80.17  ?  193 VAL A N   1 
ATOM   1406 C CA  . VAL A 1 199 ? 1.690   -21.191 -20.896 1.00 85.43  ?  193 VAL A CA  1 
ATOM   1407 C C   . VAL A 1 199 ? 1.657   -20.057 -21.904 1.00 88.99  ?  193 VAL A C   1 
ATOM   1408 O O   . VAL A 1 199 ? 0.720   -19.943 -22.705 1.00 86.42  ?  193 VAL A O   1 
ATOM   1409 C CB  . VAL A 1 199 ? 2.307   -22.459 -21.521 1.00 80.93  ?  193 VAL A CB  1 
ATOM   1410 C CG1 . VAL A 1 199 ? 2.486   -23.515 -20.451 1.00 84.50  ?  193 VAL A CG1 1 
ATOM   1411 C CG2 . VAL A 1 199 ? 1.428   -22.988 -22.644 1.00 82.24  ?  193 VAL A CG2 1 
ATOM   1412 N N   . GLU A 1 200 ? 2.690   -19.219 -21.846 1.00 88.97  ?  194 GLU A N   1 
ATOM   1413 C CA  . GLU A 1 200 ? 2.907   -18.129 -22.787 1.00 94.22  ?  194 GLU A CA  1 
ATOM   1414 C C   . GLU A 1 200 ? 4.054   -18.520 -23.721 1.00 98.67  ?  194 GLU A C   1 
ATOM   1415 O O   . GLU A 1 200 ? 5.212   -18.621 -23.288 1.00 93.46  ?  194 GLU A O   1 
ATOM   1416 C CB  . GLU A 1 200 ? 3.202   -16.826 -22.042 1.00 91.41  ?  194 GLU A CB  1 
ATOM   1417 C CG  . GLU A 1 200 ? 2.817   -15.592 -22.826 1.00 92.97  ?  194 GLU A CG  1 
ATOM   1418 C CD  . GLU A 1 200 ? 3.228   -14.295 -22.158 1.00 89.02  ?  194 GLU A CD  1 
ATOM   1419 O OE1 . GLU A 1 200 ? 2.997   -14.150 -20.933 1.00 82.97  ?  194 GLU A OE1 1 
ATOM   1420 O OE2 . GLU A 1 200 ? 3.765   -13.414 -22.871 1.00 92.10  -1 194 GLU A OE2 1 
ATOM   1421 N N   . LEU A 1 201 ? 3.721   -18.753 -24.994 1.00 102.01 ?  195 LEU A N   1 
ATOM   1422 C CA  . LEU A 1 201 ? 4.724   -19.082 -26.013 1.00 107.25 ?  195 LEU A CA  1 
ATOM   1423 C C   . LEU A 1 201 ? 4.613   -18.146 -27.221 1.00 102.55 ?  195 LEU A C   1 
ATOM   1424 O O   . LEU A 1 201 ? 4.986   -18.509 -28.337 1.00 102.23 ?  195 LEU A O   1 
ATOM   1425 C CB  . LEU A 1 201 ? 4.589   -20.549 -26.468 1.00 110.92 ?  195 LEU A CB  1 
ATOM   1426 C CG  . LEU A 1 201 ? 5.558   -21.591 -25.902 1.00 105.92 ?  195 LEU A CG  1 
ATOM   1427 C CD1 . LEU A 1 201 ? 6.948   -21.443 -26.490 1.00 108.31 ?  195 LEU A CD1 1 
ATOM   1428 C CD2 . LEU A 1 201 ? 5.574   -21.479 -24.387 1.00 105.01 ?  195 LEU A CD2 1 
ATOM   1429 N N   . LYS A 1 211 ? -1.202  -32.156 -28.530 1.00 116.75 ?  205 LYS A N   1 
ATOM   1430 C CA  . LYS A 1 211 ? 0.222   -32.490 -28.527 1.00 123.61 ?  205 LYS A CA  1 
ATOM   1431 C C   . LYS A 1 211 ? 1.059   -31.211 -28.576 1.00 123.42 ?  205 LYS A C   1 
ATOM   1432 O O   . LYS A 1 211 ? 1.625   -30.783 -27.557 1.00 122.50 ?  205 LYS A O   1 
ATOM   1433 C CB  . LYS A 1 211 ? 0.563   -33.412 -29.711 1.00 123.33 ?  205 LYS A CB  1 
ATOM   1434 C CG  . LYS A 1 211 ? 1.713   -34.392 -29.458 1.00 122.01 ?  205 LYS A CG  1 
ATOM   1435 C CD  . LYS A 1 211 ? 2.873   -34.166 -30.425 1.00 121.12 ?  205 LYS A CD  1 
ATOM   1436 C CE  . LYS A 1 211 ? 4.098   -33.593 -29.713 1.00 121.59 ?  205 LYS A CE  1 
ATOM   1437 N NZ  . LYS A 1 211 ? 5.336   -34.386 -29.955 1.00 116.75 ?  205 LYS A NZ  1 
ATOM   1438 N N   . GLU A 1 212 ? 1.127   -30.620 -29.775 1.00 122.63 ?  206 GLU A N   1 
ATOM   1439 C CA  . GLU A 1 212 ? 1.760   -29.327 -30.016 1.00 119.04 ?  206 GLU A CA  1 
ATOM   1440 C C   . GLU A 1 212 ? 3.159   -29.261 -29.414 1.00 121.15 ?  206 GLU A C   1 
ATOM   1441 O O   . GLU A 1 212 ? 4.157   -29.453 -30.120 1.00 121.38 ?  206 GLU A O   1 
ATOM   1442 C CB  . GLU A 1 212 ? 0.859   -28.217 -29.469 1.00 120.30 ?  206 GLU A CB  1 
ATOM   1443 C CG  . GLU A 1 212 ? 1.448   -26.818 -29.394 1.00 119.71 ?  206 GLU A CG  1 
ATOM   1444 C CD  . GLU A 1 212 ? 0.779   -26.001 -28.299 1.00 115.28 ?  206 GLU A CD  1 
ATOM   1445 O OE1 . GLU A 1 212 ? 1.040   -26.274 -27.110 1.00 112.33 ?  206 GLU A OE1 1 
ATOM   1446 O OE2 . GLU A 1 212 ? -0.028  -25.106 -28.624 1.00 110.68 ?  206 GLU A OE2 1 
ATOM   1447 N N   . ARG A 1 213 ? 3.248   -29.017 -28.112 1.00 119.53 ?  207 ARG A N   1 
ATOM   1448 C CA  . ARG A 1 213 ? 4.531   -28.746 -27.492 1.00 119.74 ?  207 ARG A CA  1 
ATOM   1449 C C   . ARG A 1 213 ? 5.110   -30.010 -26.889 1.00 117.85 ?  207 ARG A C   1 
ATOM   1450 O O   . ARG A 1 213 ? 4.462   -31.057 -26.813 1.00 120.44 ?  207 ARG A O   1 
ATOM   1451 C CB  . ARG A 1 213 ? 4.397   -27.641 -26.441 1.00 117.03 ?  207 ARG A CB  1 
ATOM   1452 C CG  . ARG A 1 213 ? 4.263   -26.194 -27.005 1.00 113.04 ?  207 ARG A CG  1 
ATOM   1453 C CD  . ARG A 1 213 ? 5.148   -25.824 -28.231 1.00 114.36 ?  207 ARG A CD  1 
ATOM   1454 N NE  . ARG A 1 213 ? 4.955   -26.655 -29.416 1.00 119.53 ?  207 ARG A NE  1 
ATOM   1455 C CZ  . ARG A 1 213 ? 5.853   -26.847 -30.374 1.00 119.22 ?  207 ARG A CZ  1 
ATOM   1456 N NH1 . ARG A 1 213 ? 6.997   -26.176 -30.399 1.00 120.01 ?  207 ARG A NH1 1 
ATOM   1457 N NH2 . ARG A 1 213 ? 5.597   -27.735 -31.330 1.00 112.24 ?  207 ARG A NH2 1 
ATOM   1458 N N   . ILE A 1 214 ? 6.361   -29.897 -26.459 1.00 116.72 ?  208 ILE A N   1 
ATOM   1459 C CA  . ILE A 1 214 ? 7.042   -30.990 -25.778 1.00 122.38 ?  208 ILE A CA  1 
ATOM   1460 C C   . ILE A 1 214 ? 6.558   -31.036 -24.329 1.00 124.46 ?  208 ILE A C   1 
ATOM   1461 O O   . ILE A 1 214 ? 7.300   -31.442 -23.423 1.00 123.17 ?  208 ILE A O   1 
ATOM   1462 C CB  . ILE A 1 214 ? 8.576   -30.842 -25.893 1.00 123.08 ?  208 ILE A CB  1 
ATOM   1463 C CG1 . ILE A 1 214 ? 9.108   -29.638 -25.102 1.00 120.14 ?  208 ILE A CG1 1 
ATOM   1464 C CG2 . ILE A 1 214 ? 8.987   -30.714 -27.363 1.00 116.73 ?  208 ILE A CG2 1 
ATOM   1465 C CD1 . ILE A 1 214 ? 10.567  -29.287 -25.402 1.00 108.95 ?  208 ILE A CD1 1 
ATOM   1466 N N   . LEU A 1 215 ? 5.292   -30.646 -24.120 1.00 124.76 ?  209 LEU A N   1 
ATOM   1467 C CA  . LEU A 1 215 ? 4.716   -30.566 -22.781 1.00 123.49 ?  209 LEU A CA  1 
ATOM   1468 C C   . LEU A 1 215 ? 5.008   -31.820 -21.970 1.00 127.68 ?  209 LEU A C   1 
ATOM   1469 O O   . LEU A 1 215 ? 5.407   -31.731 -20.801 1.00 126.21 ?  209 LEU A O   1 
ATOM   1470 C CB  . LEU A 1 215 ? 3.209   -30.297 -22.886 1.00 119.58 ?  209 LEU A CB  1 
ATOM   1471 C CG  . LEU A 1 215 ? 2.317   -31.009 -23.923 1.00 115.38 ?  209 LEU A CG  1 
ATOM   1472 C CD1 . LEU A 1 215 ? 2.106   -32.493 -23.655 1.00 115.15 ?  209 LEU A CD1 1 
ATOM   1473 C CD2 . LEU A 1 215 ? 0.979   -30.290 -24.045 1.00 98.76  ?  209 LEU A CD2 1 
ATOM   1474 N N   . GLN A 1 216 ? 4.879   -32.991 -22.609 1.00 126.31 ?  210 GLN A N   1 
ATOM   1475 C CA  . GLN A 1 216 ? 4.984   -34.314 -21.995 1.00 130.79 ?  210 GLN A CA  1 
ATOM   1476 C C   . GLN A 1 216 ? 4.684   -34.302 -20.502 1.00 133.69 ?  210 GLN A C   1 
ATOM   1477 O O   . GLN A 1 216 ? 3.605   -33.861 -20.080 1.00 126.91 ?  210 GLN A O   1 
ATOM   1478 C CB  . GLN A 1 216 ? 6.376   -34.907 -22.245 1.00 128.84 ?  210 GLN A CB  1 
ATOM   1479 C CG  . GLN A 1 216 ? 6.719   -35.057 -23.719 1.00 129.47 ?  210 GLN A CG  1 
ATOM   1480 C CD  . GLN A 1 216 ? 8.185   -34.798 -24.018 1.00 131.67 ?  210 GLN A CD  1 
ATOM   1481 O OE1 . GLN A 1 216 ? 8.988   -34.575 -23.108 1.00 133.96 ?  210 GLN A OE1 1 
ATOM   1482 N NE2 . GLN A 1 216 ? 8.536   -34.799 -25.302 1.00 130.19 ?  210 GLN A NE2 1 
ATOM   1483 N N   . ASP A 1 217 ? 5.650   -34.746 -19.692 1.00 131.16 ?  211 ASP A N   1 
ATOM   1484 C CA  . ASP A 1 217 ? 5.499   -34.754 -18.237 1.00 128.25 ?  211 ASP A CA  1 
ATOM   1485 C C   . ASP A 1 217 ? 6.869   -34.723 -17.561 1.00 122.98 ?  211 ASP A C   1 
ATOM   1486 O O   . ASP A 1 217 ? 7.310   -35.713 -16.962 1.00 122.75 ?  211 ASP A O   1 
ATOM   1487 C CB  . ASP A 1 217 ? 4.698   -35.978 -17.796 1.00 125.47 ?  211 ASP A CB  1 
ATOM   1488 C CG  . ASP A 1 217 ? 4.980   -37.197 -18.655 1.00 129.48 ?  211 ASP A CG  1 
ATOM   1489 O OD1 . ASP A 1 217 ? 6.076   -37.256 -19.253 1.00 129.93 ?  211 ASP A OD1 1 
ATOM   1490 O OD2 . ASP A 1 217 ? 4.129   -38.109 -18.709 1.00 125.41 ?  211 ASP A OD2 1 
ATOM   1491 N N   . PRO A 1 218 ? 7.568   -33.570 -17.610 1.00 125.12 ?  212 PRO A N   1 
ATOM   1492 C CA  . PRO A 1 218 ? 8.675   -33.361 -16.662 1.00 124.10 ?  212 PRO A CA  1 
ATOM   1493 C C   . PRO A 1 218 ? 8.154   -33.345 -15.234 1.00 122.85 ?  212 PRO A C   1 
ATOM   1494 O O   . PRO A 1 218 ? 7.852   -32.273 -14.697 1.00 114.73 ?  212 PRO A O   1 
ATOM   1495 C CB  . PRO A 1 218 ? 9.265   -32.001 -17.062 1.00 119.81 ?  212 PRO A CB  1 
ATOM   1496 C CG  . PRO A 1 218 ? 8.595   -31.583 -18.315 1.00 121.16 ?  212 PRO A CG  1 
ATOM   1497 C CD  . PRO A 1 218 ? 7.519   -32.550 -18.673 1.00 125.13 ?  212 PRO A CD  1 
ATOM   1498 N N   . TYR A 1 219 ? 8.076   -34.524 -14.623 1.00 121.60 ?  213 TYR A N   1 
ATOM   1499 C CA  . TYR A 1 219 ? 7.196   -34.845 -13.489 1.00 120.58 ?  213 TYR A CA  1 
ATOM   1500 C C   . TYR A 1 219 ? 5.769   -34.443 -13.923 1.00 125.02 ?  213 TYR A C   1 
ATOM   1501 O O   . TYR A 1 219 ? 5.427   -34.617 -15.096 1.00 126.45 ?  213 TYR A O   1 
ATOM   1502 C CB  . TYR A 1 219 ? 7.749   -34.255 -12.175 1.00 119.28 ?  213 TYR A CB  1 
ATOM   1503 C CG  . TYR A 1 219 ? 7.226   -32.934 -11.615 1.00 124.67 ?  213 TYR A CG  1 
ATOM   1504 C CD1 . TYR A 1 219 ? 6.146   -32.907 -10.726 1.00 119.72 ?  213 TYR A CD1 1 
ATOM   1505 C CD2 . TYR A 1 219 ? 7.875   -31.733 -11.888 1.00 120.20 ?  213 TYR A CD2 1 
ATOM   1506 C CE1 . TYR A 1 219 ? 5.686   -31.730 -10.194 1.00 116.94 ?  213 TYR A CE1 1 
ATOM   1507 C CE2 . TYR A 1 219 ? 7.426   -30.544 -11.354 1.00 118.14 ?  213 TYR A CE2 1 
ATOM   1508 C CZ  . TYR A 1 219 ? 6.330   -30.546 -10.496 1.00 122.08 ?  213 TYR A CZ  1 
ATOM   1509 O OH  . TYR A 1 219 ? 5.852   -29.363 -9.950  1.00 116.95 ?  213 TYR A OH  1 
ATOM   1510 N N   . PHE A 1 220 ? 4.882   -33.993 -13.023 1.00 121.35 ?  214 PHE A N   1 
ATOM   1511 C CA  . PHE A 1 220 ? 3.480   -33.712 -13.351 1.00 113.70 ?  214 PHE A CA  1 
ATOM   1512 C C   . PHE A 1 220 ? 2.705   -34.971 -13.734 1.00 112.61 ?  214 PHE A C   1 
ATOM   1513 O O   . PHE A 1 220 ? 1.473   -35.005 -13.617 1.00 104.00 ?  214 PHE A O   1 
ATOM   1514 C CB  . PHE A 1 220 ? 3.347   -32.719 -14.514 1.00 115.89 ?  214 PHE A CB  1 
ATOM   1515 C CG  . PHE A 1 220 ? 3.451   -31.287 -14.120 1.00 115.90 ?  214 PHE A CG  1 
ATOM   1516 C CD1 . PHE A 1 220 ? 4.095   -30.917 -12.958 1.00 117.59 ?  214 PHE A CD1 1 
ATOM   1517 C CD2 . PHE A 1 220 ? 2.885   -30.309 -14.906 1.00 113.30 ?  214 PHE A CD2 1 
ATOM   1518 C CE1 . PHE A 1 220 ? 4.195   -29.584 -12.607 1.00 112.99 ?  214 PHE A CE1 1 
ATOM   1519 C CE2 . PHE A 1 220 ? 2.977   -28.987 -14.551 1.00 111.79 ?  214 PHE A CE2 1 
ATOM   1520 C CZ  . PHE A 1 220 ? 3.628   -28.625 -13.394 1.00 109.39 ?  214 PHE A CZ  1 
ATOM   1521 N N   . VAL A 1 221 ? 3.430   -35.993 -14.212 1.00 118.21 ?  215 VAL A N   1 
ATOM   1522 C CA  . VAL A 1 221 ? 2.825   -37.189 -14.800 1.00 116.52 ?  215 VAL A CA  1 
ATOM   1523 C C   . VAL A 1 221 ? 1.886   -37.867 -13.813 1.00 110.12 ?  215 VAL A C   1 
ATOM   1524 O O   . VAL A 1 221 ? 0.824   -38.375 -14.195 1.00 107.39 ?  215 VAL A O   1 
ATOM   1525 C CB  . VAL A 1 221 ? 3.926   -38.153 -15.284 1.00 118.18 ?  215 VAL A CB  1 
ATOM   1526 C CG1 . VAL A 1 221 ? 4.994   -38.340 -14.201 1.00 116.87 ?  215 VAL A CG1 1 
ATOM   1527 C CG2 . VAL A 1 221 ? 3.328   -39.489 -15.707 1.00 117.82 ?  215 VAL A CG2 1 
ATOM   1528 N N   . HIS A 1 222 ? 2.252   -37.876 -12.532 1.00 108.03 ?  216 HIS A N   1 
ATOM   1529 C CA  . HIS A 1 222 ? 1.403   -38.483 -11.516 1.00 110.04 ?  216 HIS A CA  1 
ATOM   1530 C C   . HIS A 1 222 ? 0.346   -37.496 -11.035 1.00 109.39 ?  216 HIS A C   1 
ATOM   1531 O O   . HIS A 1 222 ? -0.100  -37.572 -9.884  1.00 110.79 ?  216 HIS A O   1 
ATOM   1532 C CB  . HIS A 1 222 ? 2.243   -39.002 -10.342 1.00 110.59 ?  216 HIS A CB  1 
ATOM   1533 C CG  . HIS A 1 222 ? 3.387   -39.881 -10.755 1.00 112.64 ?  216 HIS A CG  1 
ATOM   1534 N ND1 . HIS A 1 222 ? 3.249   -40.906 -11.668 1.00 110.64 ?  216 HIS A ND1 1 
ATOM   1535 C CD2 . HIS A 1 222 ? 4.687   -39.890 -10.375 1.00 114.46 ?  216 HIS A CD2 1 
ATOM   1536 C CE1 . HIS A 1 222 ? 4.416   -41.502 -11.838 1.00 112.95 ?  216 HIS A CE1 1 
ATOM   1537 N NE2 . HIS A 1 222 ? 5.305   -40.907 -11.063 1.00 114.40 ?  216 HIS A NE2 1 
ATOM   1538 N N   . ASP A 1 223 ? -0.057  -36.569 -11.911 1.00 104.43 ?  217 ASP A N   1 
ATOM   1539 C CA  . ASP A 1 223 ? -1.176  -35.669 -11.665 1.00 98.37  ?  217 ASP A CA  1 
ATOM   1540 C C   . ASP A 1 223 ? -1.951  -35.477 -12.964 1.00 92.42  ?  217 ASP A C   1 
ATOM   1541 O O   . ASP A 1 223 ? -1.344  -35.306 -14.027 1.00 94.19  ?  217 ASP A O   1 
ATOM   1542 C CB  . ASP A 1 223 ? -0.688  -34.315 -11.128 1.00 103.37 ?  217 ASP A CB  1 
ATOM   1543 C CG  . ASP A 1 223 ? -0.386  -34.344 -9.632  1.00 105.68 ?  217 ASP A CG  1 
ATOM   1544 O OD1 . ASP A 1 223 ? -0.744  -35.344 -8.971  1.00 100.98 -1 217 ASP A OD1 1 
ATOM   1545 O OD2 . ASP A 1 223 ? 0.218   -33.366 -9.123  1.00 106.75 ?  217 ASP A OD2 1 
ATOM   1546 N N   . GLU A 1 224 ? -3.286  -35.539 -12.884 1.00 83.45  ?  218 GLU A N   1 
ATOM   1547 C CA  . GLU A 1 224 ? -4.114  -35.147 -14.021 1.00 78.58  ?  218 GLU A CA  1 
ATOM   1548 C C   . GLU A 1 224 ? -3.846  -33.691 -14.365 1.00 80.59  ?  218 GLU A C   1 
ATOM   1549 O O   . GLU A 1 224 ? -3.895  -32.817 -13.495 1.00 80.49  ?  218 GLU A O   1 
ATOM   1550 C CB  . GLU A 1 224 ? -5.598  -35.324 -13.717 1.00 78.38  ?  218 GLU A CB  1 
ATOM   1551 C CG  . GLU A 1 224 ? -6.499  -34.515 -14.652 1.00 75.72  ?  218 GLU A CG  1 
ATOM   1552 C CD  . GLU A 1 224 ? -7.884  -34.261 -14.070 1.00 86.01  ?  218 GLU A CD  1 
ATOM   1553 O OE1 . GLU A 1 224 ? -8.257  -34.990 -13.123 1.00 89.21  ?  218 GLU A OE1 1 
ATOM   1554 O OE2 . GLU A 1 224 ? -8.603  -33.343 -14.553 1.00 83.95  -1 218 GLU A OE2 1 
ATOM   1555 N N   . THR A 1 225 ? -3.561  -33.421 -15.633 1.00 77.56  ?  219 THR A N   1 
ATOM   1556 C CA  . THR A 1 225 ? -3.049  -32.109 -15.992 1.00 79.47  ?  219 THR A CA  1 
ATOM   1557 C C   . THR A 1 225 ? -3.682  -31.632 -17.285 1.00 77.79  ?  219 THR A C   1 
ATOM   1558 O O   . THR A 1 225 ? -3.959  -32.426 -18.188 1.00 80.94  ?  219 THR A O   1 
ATOM   1559 C CB  . THR A 1 225 ? -1.524  -32.138 -16.110 1.00 77.41  ?  219 THR A CB  1 
ATOM   1560 O OG1 . THR A 1 225 ? -0.959  -32.188 -14.791 1.00 84.12  ?  219 THR A OG1 1 
ATOM   1561 C CG2 . THR A 1 225 ? -1.006  -30.911 -16.843 1.00 76.50  ?  219 THR A CG2 1 
ATOM   1562 N N   . HIS A 1 226 ? -3.944  -30.335 -17.345 1.00 72.27  ?  220 HIS A N   1 
ATOM   1563 C CA  . HIS A 1 226 ? -4.478  -29.696 -18.533 1.00 79.35  ?  220 HIS A CA  1 
ATOM   1564 C C   . HIS A 1 226 ? -3.610  -28.490 -18.843 1.00 76.33  ?  220 HIS A C   1 
ATOM   1565 O O   . HIS A 1 226 ? -3.312  -27.697 -17.945 1.00 77.12  ?  220 HIS A O   1 
ATOM   1566 C CB  . HIS A 1 226 ? -5.944  -29.282 -18.332 1.00 76.04  ?  220 HIS A CB  1 
ATOM   1567 C CG  . HIS A 1 226 ? -6.826  -30.400 -17.877 1.00 75.39  ?  220 HIS A CG  1 
ATOM   1568 N ND1 . HIS A 1 226 ? -7.672  -31.073 -18.732 1.00 74.14  ?  220 HIS A ND1 1 
ATOM   1569 C CD2 . HIS A 1 226 ? -6.989  -30.969 -16.659 1.00 76.11  ?  220 HIS A CD2 1 
ATOM   1570 C CE1 . HIS A 1 226 ? -8.325  -32.004 -18.058 1.00 70.25  ?  220 HIS A CE1 1 
ATOM   1571 N NE2 . HIS A 1 226 ? -7.926  -31.965 -16.799 1.00 74.84  ?  220 HIS A NE2 1 
ATOM   1572 N N   . VAL A 1 227 ? -3.195  -28.360 -20.103 1.00 81.22  ?  221 VAL A N   1 
ATOM   1573 C CA  . VAL A 1 227 ? -2.339  -27.258 -20.534 1.00 83.49  ?  221 VAL A CA  1 
ATOM   1574 C C   . VAL A 1 227 ? -3.122  -26.341 -21.465 1.00 80.92  ?  221 VAL A C   1 
ATOM   1575 O O   . VAL A 1 227 ? -4.051  -26.765 -22.160 1.00 81.47  ?  221 VAL A O   1 
ATOM   1576 C CB  . VAL A 1 227 ? -1.050  -27.756 -21.216 1.00 76.55  ?  221 VAL A CB  1 
ATOM   1577 C CG1 . VAL A 1 227 ? -0.000  -26.685 -21.148 1.00 76.12  ?  221 VAL A CG1 1 
ATOM   1578 C CG2 . VAL A 1 227 ? -0.558  -29.011 -20.539 1.00 73.62  ?  221 VAL A CG2 1 
ATOM   1579 N N   . LEU A 1 228 ? -2.745  -25.067 -21.463 1.00 83.41  ?  222 LEU A N   1 
ATOM   1580 C CA  . LEU A 1 228 ? -3.433  -24.055 -22.255 1.00 84.16  ?  222 LEU A CA  1 
ATOM   1581 C C   . LEU A 1 228 ? -2.476  -22.904 -22.526 1.00 84.42  ?  222 LEU A C   1 
ATOM   1582 O O   . LEU A 1 228 ? -1.853  -22.372 -21.601 1.00 82.31  ?  222 LEU A O   1 
ATOM   1583 C CB  . LEU A 1 228 ? -4.695  -23.563 -21.536 1.00 83.60  ?  222 LEU A CB  1 
ATOM   1584 C CG  . LEU A 1 228 ? -5.587  -22.472 -22.131 1.00 84.16  ?  222 LEU A CG  1 
ATOM   1585 C CD1 . LEU A 1 228 ? -5.618  -22.488 -23.655 1.00 84.13  ?  222 LEU A CD1 1 
ATOM   1586 C CD2 . LEU A 1 228 ? -6.982  -22.652 -21.562 1.00 85.96  ?  222 LEU A CD2 1 
ATOM   1587 N N   . GLN A 1 229 ? -2.352  -22.544 -23.802 1.00 90.03  ?  223 GLN A N   1 
ATOM   1588 C CA  . GLN A 1 229 ? -1.574  -21.385 -24.210 1.00 90.29  ?  223 GLN A CA  1 
ATOM   1589 C C   . GLN A 1 229 ? -2.429  -20.134 -24.095 1.00 85.29  ?  223 GLN A C   1 
ATOM   1590 O O   . GLN A 1 229 ? -3.555  -20.100 -24.595 1.00 85.06  ?  223 GLN A O   1 
ATOM   1591 C CB  . GLN A 1 229 ? -1.081  -21.560 -25.644 1.00 94.61  ?  223 GLN A CB  1 
ATOM   1592 C CG  . GLN A 1 229 ? -0.439  -20.328 -26.252 1.00 97.00  ?  223 GLN A CG  1 
ATOM   1593 C CD  . GLN A 1 229 ? 0.558   -20.679 -27.342 1.00 100.47 ?  223 GLN A CD  1 
ATOM   1594 O OE1 . GLN A 1 229 ? 1.707   -20.238 -27.310 1.00 99.81  ?  223 GLN A OE1 1 
ATOM   1595 N NE2 . GLN A 1 229 ? 0.123   -21.483 -28.310 1.00 95.69  ?  223 GLN A NE2 1 
ATOM   1596 N N   . VAL A 1 230 ? -1.902  -19.112 -23.427 1.00 83.21  ?  224 VAL A N   1 
ATOM   1597 C CA  . VAL A 1 230 ? -2.603  -17.845 -23.280 1.00 91.31  ?  224 VAL A CA  1 
ATOM   1598 C C   . VAL A 1 230 ? -1.676  -16.718 -23.729 1.00 91.23  ?  224 VAL A C   1 
ATOM   1599 O O   . VAL A 1 230 ? -0.467  -16.898 -23.895 1.00 93.16  ?  224 VAL A O   1 
ATOM   1600 C CB  . VAL A 1 230 ? -3.101  -17.603 -21.837 1.00 86.88  ?  224 VAL A CB  1 
ATOM   1601 C CG1 . VAL A 1 230 ? -4.254  -18.546 -21.505 1.00 83.73  ?  224 VAL A CG1 1 
ATOM   1602 C CG2 . VAL A 1 230 ? -1.971  -17.753 -20.843 1.00 83.24  ?  224 VAL A CG2 1 
ATOM   1603 N N   . ASP A 1 231 ? -2.268  -15.537 -23.926 1.00 93.55  ?  225 ASP A N   1 
ATOM   1604 C CA  . ASP A 1 231 ? -1.490  -14.402 -24.414 1.00 92.05  ?  225 ASP A CA  1 
ATOM   1605 C C   . ASP A 1 231 ? -0.577  -13.846 -23.327 1.00 90.96  ?  225 ASP A C   1 
ATOM   1606 O O   . ASP A 1 231 ? 0.607   -13.585 -23.575 1.00 91.75  ?  225 ASP A O   1 
ATOM   1607 C CB  . ASP A 1 231 ? -2.421  -13.308 -24.936 1.00 91.28  ?  225 ASP A CB  1 
ATOM   1608 C CG  . ASP A 1 231 ? -2.724  -13.455 -26.412 1.00 97.84  ?  225 ASP A CG  1 
ATOM   1609 O OD1 . ASP A 1 231 ? -2.044  -14.260 -27.086 1.00 93.90  ?  225 ASP A OD1 1 
ATOM   1610 O OD2 . ASP A 1 231 ? -3.654  -12.765 -26.894 1.00 105.80 -1 225 ASP A OD2 1 
ATOM   1611 N N   . ASP A 1 232 ? -1.106  -13.654 -22.111 1.00 84.59  ?  226 ASP A N   1 
ATOM   1612 C CA  . ASP A 1 232 ? -0.359  -12.916 -21.086 1.00 81.36  ?  226 ASP A CA  1 
ATOM   1613 C C   . ASP A 1 232 ? -0.696  -13.507 -19.718 1.00 76.16  ?  226 ASP A C   1 
ATOM   1614 O O   . ASP A 1 232 ? -1.642  -13.065 -19.061 1.00 76.54  ?  226 ASP A O   1 
ATOM   1615 C CB  . ASP A 1 232 ? -0.675  -11.428 -21.131 1.00 74.95  ?  226 ASP A CB  1 
ATOM   1616 C CG  . ASP A 1 232 ? 0.176   -10.627 -20.159 1.00 79.65  ?  226 ASP A CG  1 
ATOM   1617 O OD1 . ASP A 1 232 ? 1.217   -11.163 -19.710 1.00 86.63  ?  226 ASP A OD1 1 
ATOM   1618 O OD2 . ASP A 1 232 ? -0.187  -9.471  -19.837 1.00 74.55  -1 226 ASP A OD2 1 
ATOM   1619 N N   . VAL A 1 233 ? 0.117   -14.474 -19.280 1.00 70.45  ?  227 VAL A N   1 
ATOM   1620 C CA  . VAL A 1 233 ? -0.139  -15.132 -18.006 1.00 72.24  ?  227 VAL A CA  1 
ATOM   1621 C C   . VAL A 1 233 ? -0.123  -14.154 -16.832 1.00 71.81  ?  227 VAL A C   1 
ATOM   1622 O O   . VAL A 1 233 ? -0.741  -14.428 -15.797 1.00 71.30  ?  227 VAL A O   1 
ATOM   1623 C CB  . VAL A 1 233 ? 0.855   -16.298 -17.796 1.00 75.95  ?  227 VAL A CB  1 
ATOM   1624 C CG1 . VAL A 1 233 ? 1.005   -17.072 -19.092 1.00 79.81  ?  227 VAL A CG1 1 
ATOM   1625 C CG2 . VAL A 1 233 ? 2.198   -15.813 -17.289 1.00 72.80  ?  227 VAL A CG2 1 
ATOM   1626 N N   . LYS A 1 234 ? 0.543   -13.005 -16.966 1.00 70.63  ?  228 LYS A N   1 
ATOM   1627 C CA  . LYS A 1 234 ? 0.442   -11.989 -15.923 1.00 73.23  ?  228 LYS A CA  1 
ATOM   1628 C C   . LYS A 1 234 ? -1.004  -11.536 -15.737 1.00 65.06  ?  228 LYS A C   1 
ATOM   1629 O O   . LYS A 1 234 ? -1.437  -11.249 -14.615 1.00 62.27  ?  228 LYS A O   1 
ATOM   1630 C CB  . LYS A 1 234 ? 1.343   -10.791 -16.252 1.00 73.86  ?  228 LYS A CB  1 
ATOM   1631 C CG  . LYS A 1 234 ? 2.832   -11.072 -16.207 1.00 77.58  ?  228 LYS A CG  1 
ATOM   1632 C CD  . LYS A 1 234 ? 3.610   -9.778  -16.323 1.00 79.32  ?  228 LYS A CD  1 
ATOM   1633 C CE  . LYS A 1 234 ? 4.253   -9.402  -15.009 1.00 81.47  ?  228 LYS A CE  1 
ATOM   1634 N NZ  . LYS A 1 234 ? 5.497   -8.614  -15.256 1.00 95.76  ?  228 LYS A NZ  1 
ATOM   1635 N N   . GLN A 1 235 ? -1.762  -11.455 -16.824 1.00 60.91  ?  229 GLN A N   1 
ATOM   1636 C CA  . GLN A 1 235 ? -3.150  -11.045 -16.708 1.00 60.94  ?  229 GLN A CA  1 
ATOM   1637 C C   . GLN A 1 235 ? -3.994  -12.020 -15.879 1.00 60.60  ?  229 GLN A C   1 
ATOM   1638 O O   . GLN A 1 235 ? -5.106  -11.662 -15.477 1.00 59.95  ?  229 GLN A O   1 
ATOM   1639 C CB  . GLN A 1 235 ? -3.723  -10.876 -18.115 1.00 62.14  ?  229 GLN A CB  1 
ATOM   1640 C CG  . GLN A 1 235 ? -4.826  -9.838  -18.241 1.00 61.93  ?  229 GLN A CG  1 
ATOM   1641 C CD  . GLN A 1 235 ? -4.375  -8.472  -17.786 1.00 65.48  ?  229 GLN A CD  1 
ATOM   1642 O OE1 . GLN A 1 235 ? -4.929  -7.901  -16.845 1.00 63.79  ?  229 GLN A OE1 1 
ATOM   1643 N NE2 . GLN A 1 235 ? -3.345  -7.943  -18.440 1.00 69.78  ?  229 GLN A NE2 1 
ATOM   1644 N N   . LEU A 1 236 ? -3.491  -13.219 -15.580 1.00 61.24  ?  230 LEU A N   1 
ATOM   1645 C CA  . LEU A 1 236 ? -4.274  -14.242 -14.899 1.00 62.56  ?  230 LEU A CA  1 
ATOM   1646 C C   . LEU A 1 236 ? -4.018  -14.333 -13.399 1.00 62.26  ?  230 LEU A C   1 
ATOM   1647 O O   . LEU A 1 236 ? -4.642  -15.173 -12.737 1.00 63.96  ?  230 LEU A O   1 
ATOM   1648 C CB  . LEU A 1 236 ? -4.027  -15.625 -15.524 1.00 59.98  ?  230 LEU A CB  1 
ATOM   1649 C CG  . LEU A 1 236 ? -4.005  -15.735 -17.048 1.00 66.09  ?  230 LEU A CG  1 
ATOM   1650 C CD1 . LEU A 1 236 ? -3.746  -17.163 -17.508 1.00 66.58  ?  230 LEU A CD1 1 
ATOM   1651 C CD2 . LEU A 1 236 ? -5.310  -15.241 -17.612 1.00 60.39  ?  230 LEU A CD2 1 
ATOM   1652 N N   . ILE A 1 237 ? -3.146  -13.509 -12.833 1.00 55.93  ?  231 ILE A N   1 
ATOM   1653 C CA  . ILE A 1 237 ? -2.609  -13.809 -11.510 1.00 56.99  ?  231 ILE A CA  1 
ATOM   1654 C C   . ILE A 1 237 ? -3.425  -13.123 -10.432 1.00 56.06  ?  231 ILE A C   1 
ATOM   1655 O O   . ILE A 1 237 ? -3.655  -11.913 -10.482 1.00 60.88  ?  231 ILE A O   1 
ATOM   1656 C CB  . ILE A 1 237 ? -1.132  -13.413 -11.403 1.00 60.74  ?  231 ILE A CB  1 
ATOM   1657 C CG1 . ILE A 1 237 ? -0.289  -14.400 -12.223 1.00 64.20  ?  231 ILE A CG1 1 
ATOM   1658 C CG2 . ILE A 1 237 ? -0.731  -13.385 -9.926  1.00 53.48  ?  231 ILE A CG2 1 
ATOM   1659 C CD1 . ILE A 1 237 ? 1.187   -14.111 -12.237 1.00 60.93  ?  231 ILE A CD1 1 
ATOM   1660 N N   . ASP A 1 238 ? -3.851  -13.900 -9.443  1.00 60.42  ?  232 ASP A N   1 
ATOM   1661 C CA  . ASP A 1 238 ? -4.484  -13.362 -8.254  1.00 57.79  ?  232 ASP A CA  1 
ATOM   1662 C C   . ASP A 1 238 ? -4.026  -14.192 -7.071  1.00 57.46  ?  232 ASP A C   1 
ATOM   1663 O O   . ASP A 1 238 ? -4.037  -15.421 -7.139  1.00 64.11  ?  232 ASP A O   1 
ATOM   1664 C CB  . ASP A 1 238 ? -6.000  -13.399 -8.374  1.00 56.00  ?  232 ASP A CB  1 
ATOM   1665 C CG  . ASP A 1 238 ? -6.674  -13.158 -7.054  1.00 59.42  ?  232 ASP A CG  1 
ATOM   1666 O OD1 . ASP A 1 238 ? -6.852  -11.973 -6.696  1.00 61.39  ?  232 ASP A OD1 1 
ATOM   1667 O OD2 . ASP A 1 238 ? -6.991  -14.151 -6.360  1.00 61.63  -1 232 ASP A OD2 1 
ATOM   1668 N N   . ARG A 1 239 ? -3.636  -13.534 -5.987  1.00 56.04  ?  233 ARG A N   1 
ATOM   1669 C CA  . ARG A 1 239 ? -3.033  -14.232 -4.859  1.00 56.97  ?  233 ARG A CA  1 
ATOM   1670 C C   . ARG A 1 239 ? -4.062  -14.642 -3.802  1.00 55.25  ?  233 ARG A C   1 
ATOM   1671 O O   . ARG A 1 239 ? -3.722  -14.780 -2.624  1.00 57.83  ?  233 ARG A O   1 
ATOM   1672 C CB  . ARG A 1 239 ? -1.915  -13.372 -4.246  1.00 55.88  ?  233 ARG A CB  1 
ATOM   1673 C CG  . ARG A 1 239 ? -0.485  -13.588 -4.841  1.00 58.11  ?  233 ARG A CG  1 
ATOM   1674 C CD  . ARG A 1 239 ? -0.009  -15.099 -4.617  1.00 79.03  ?  233 ARG A CD  1 
ATOM   1675 N NE  . ARG A 1 239 ? 0.850   -15.403 -3.458  1.00 64.21  ?  233 ARG A NE  1 
ATOM   1676 C CZ  . ARG A 1 239 ? 0.929   -16.610 -2.924  1.00 55.59  ?  233 ARG A CZ  1 
ATOM   1677 N NH1 . ARG A 1 239 ? 0.231   -17.613 -3.419  1.00 74.74  ?  233 ARG A NH1 1 
ATOM   1678 N NH2 . ARG A 1 239 ? 1.700   -16.815 -1.857  1.00 56.57  ?  233 ARG A NH2 1 
ATOM   1679 N N   . GLY A 1 240 ? -5.320  -14.825 -4.181  1.00 58.65  ?  234 GLY A N   1 
ATOM   1680 C CA  . GLY A 1 240 ? -6.293  -15.381 -3.262  1.00 57.75  ?  234 GLY A CA  1 
ATOM   1681 C C   . GLY A 1 240 ? -6.337  -16.889 -3.359  1.00 58.18  ?  234 GLY A C   1 
ATOM   1682 O O   . GLY A 1 240 ? -5.848  -17.483 -4.312  1.00 60.39  ?  234 GLY A O   1 
ATOM   1683 N N   . ILE A 1 241 ? -6.941  -17.537 -2.367  1.00 56.85  ?  235 ILE A N   1 
ATOM   1684 C CA  . ILE A 1 241 ? -6.994  -18.990 -2.381  1.00 60.91  ?  235 ILE A CA  1 
ATOM   1685 C C   . ILE A 1 241 ? -8.105  -19.433 -1.452  1.00 53.38  ?  235 ILE A C   1 
ATOM   1686 O O   . ILE A 1 241 ? -8.454  -18.730 -0.502  1.00 52.96  ?  235 ILE A O   1 
ATOM   1687 C CB  . ILE A 1 241 ? -5.612  -19.603 -2.005  1.00 63.52  ?  235 ILE A CB  1 
ATOM   1688 C CG1 . ILE A 1 241 ? -5.445  -20.997 -2.618  1.00 66.87  ?  235 ILE A CG1 1 
ATOM   1689 C CG2 . ILE A 1 241 ? -5.378  -19.639 -0.507  1.00 57.88  ?  235 ILE A CG2 1 
ATOM   1690 C CD1 . ILE A 1 241 ? -4.046  -21.262 -3.127  1.00 67.21  ?  235 ILE A CD1 1 
ATOM   1691 N N   . GLY A 1 242 ? -8.683  -20.593 -1.746  1.00 59.06  ?  236 GLY A N   1 
ATOM   1692 C CA  . GLY A 1 242 ? -9.690  -21.197 -0.895  1.00 58.35  ?  236 GLY A CA  1 
ATOM   1693 C C   . GLY A 1 242 ? -9.116  -22.429 -0.223  1.00 60.96  ?  236 GLY A C   1 
ATOM   1694 O O   . GLY A 1 242 ? -8.236  -23.093 -0.767  1.00 63.79  ?  236 GLY A O   1 
ATOM   1695 N N   . VAL A 1 243 ? -9.591  -22.716 0.979   1.00 56.02  ?  237 VAL A N   1 
ATOM   1696 C CA  . VAL A 1 243 ? -9.207  -23.916 1.703   1.00 58.00  ?  237 VAL A CA  1 
ATOM   1697 C C   . VAL A 1 243 ? -10.475 -24.497 2.303   1.00 62.43  ?  237 VAL A C   1 
ATOM   1698 O O   . VAL A 1 243 ? -11.213 -23.785 2.995   1.00 56.95  ?  237 VAL A O   1 
ATOM   1699 C CB  . VAL A 1 243 ? -8.168  -23.631 2.809   1.00 64.57  ?  237 VAL A CB  1 
ATOM   1700 C CG1 . VAL A 1 243 ? -8.267  -24.667 3.918   1.00 66.64  ?  237 VAL A CG1 1 
ATOM   1701 C CG2 . VAL A 1 243 ? -6.747  -23.588 2.247   1.00 61.72  ?  237 VAL A CG2 1 
ATOM   1702 N N   . ARG A 1 244 ? -10.731 -25.783 2.029   1.00 64.41  ?  238 ARG A N   1 
ATOM   1703 C CA  . ARG A 1 244 ? -11.838 -26.528 2.623   1.00 59.69  ?  238 ARG A CA  1 
ATOM   1704 C C   . ARG A 1 244 ? -11.303 -27.807 3.253   1.00 62.78  ?  238 ARG A C   1 
ATOM   1705 O O   . ARG A 1 244 ? -10.796 -28.698 2.557   1.00 61.11  ?  238 ARG A O   1 
ATOM   1706 C CB  . ARG A 1 244 ? -12.918 -26.855 1.597   1.00 58.35  ?  238 ARG A CB  1 
ATOM   1707 C CG  . ARG A 1 244 ? -14.255 -27.182 2.236   1.00 64.97  ?  238 ARG A CG  1 
ATOM   1708 C CD  . ARG A 1 244 ? -15.250 -27.643 1.179   1.00 73.81  ?  238 ARG A CD  1 
ATOM   1709 N NE  . ARG A 1 244 ? -16.405 -28.330 1.746   1.00 76.17  ?  238 ARG A NE  1 
ATOM   1710 C CZ  . ARG A 1 244 ? -17.445 -27.714 2.292   1.00 83.39  ?  238 ARG A CZ  1 
ATOM   1711 N NH1 . ARG A 1 244 ? -17.484 -26.394 2.410   1.00 81.78  ?  238 ARG A NH1 1 
ATOM   1712 N NH2 . ARG A 1 244 ? -18.475 -28.440 2.729   1.00 87.90  ?  238 ARG A NH2 1 
ATOM   1713 N N   . MET A 1 245 ? -11.427 -27.895 4.567   1.00 62.03  ?  239 MET A N   1 
ATOM   1714 C CA  . MET A 1 245 ? -10.928 -29.012 5.349   1.00 61.77  ?  239 MET A CA  1 
ATOM   1715 C C   . MET A 1 245 ? -12.119 -29.764 5.923   1.00 60.55  ?  239 MET A C   1 
ATOM   1716 O O   . MET A 1 245 ? -12.991 -29.148 6.545   1.00 65.60  ?  239 MET A O   1 
ATOM   1717 C CB  . MET A 1 245 ? -10.028 -28.489 6.465   1.00 56.19  ?  239 MET A CB  1 
ATOM   1718 C CG  . MET A 1 245 ? -9.452  -29.536 7.360   1.00 55.61  ?  239 MET A CG  1 
ATOM   1719 S SD  . MET A 1 245 ? -8.208  -28.825 8.448   1.00 75.95  ?  239 MET A SD  1 
ATOM   1720 C CE  . MET A 1 245 ? -7.377  -27.664 7.349   1.00 58.11  ?  239 MET A CE  1 
ATOM   1721 N N   . GLU A 1 246 ? -12.169 -31.080 5.728   1.00 60.12  ?  240 GLU A N   1 
ATOM   1722 C CA  . GLU A 1 246 ? -13.351 -31.842 6.137   1.00 59.38  ?  240 GLU A CA  1 
ATOM   1723 C C   . GLU A 1 246 ? -12.960 -33.102 6.888   1.00 59.48  ?  240 GLU A C   1 
ATOM   1724 O O   . GLU A 1 246 ? -12.053 -33.833 6.468   1.00 62.07  ?  240 GLU A O   1 
ATOM   1725 C CB  . GLU A 1 246 ? -14.183 -32.241 4.932   1.00 57.19  ?  240 GLU A CB  1 
ATOM   1726 C CG  . GLU A 1 246 ? -15.294 -31.289 4.594   1.00 74.41  ?  240 GLU A CG  1 
ATOM   1727 C CD  . GLU A 1 246 ? -16.038 -31.729 3.342   1.00 88.85  ?  240 GLU A CD  1 
ATOM   1728 O OE1 . GLU A 1 246 ? -15.756 -32.862 2.868   1.00 89.82  ?  240 GLU A OE1 1 
ATOM   1729 O OE2 . GLU A 1 246 ? -16.876 -30.941 2.827   1.00 88.04  -1 240 GLU A OE2 1 
ATOM   1730 N N   . ARG A 1 247 ? -13.662 -33.378 7.984   1.00 58.64  ?  241 ARG A N   1 
ATOM   1731 C CA  . ARG A 1 247 ? -13.441 -34.624 8.710   1.00 60.59  ?  241 ARG A CA  1 
ATOM   1732 C C   . ARG A 1 247 ? -14.771 -35.218 9.143   1.00 57.12  ?  241 ARG A C   1 
ATOM   1733 O O   . ARG A 1 247 ? -15.633 -34.510 9.666   1.00 58.67  ?  241 ARG A O   1 
ATOM   1734 C CB  . ARG A 1 247 ? -12.532 -34.419 9.934   1.00 59.30  ?  241 ARG A CB  1 
ATOM   1735 C CG  . ARG A 1 247 ? -12.301 -35.677 10.767  1.00 54.96  ?  241 ARG A CG  1 
ATOM   1736 C CD  . ARG A 1 247 ? -11.176 -35.467 11.788  1.00 54.64  ?  241 ARG A CD  1 
ATOM   1737 N NE  . ARG A 1 247 ? -10.826 -36.690 12.496  1.00 56.94  ?  241 ARG A NE  1 
ATOM   1738 C CZ  . ARG A 1 247 ? -10.022 -37.634 12.017  1.00 61.12  ?  241 ARG A CZ  1 
ATOM   1739 N NH1 . ARG A 1 247 ? -9.448  -37.527 10.828  1.00 60.56  ?  241 ARG A NH1 1 
ATOM   1740 N NH2 . ARG A 1 247 ? -9.783  -38.718 12.748  1.00 63.45  ?  241 ARG A NH2 1 
ATOM   1741 N N   . LYS A 1 248 ? -14.931 -36.520 8.909   1.00 62.40  ?  242 LYS A N   1 
ATOM   1742 C CA  . LYS A 1 248 ? -15.995 -37.326 9.497   1.00 54.43  ?  242 LYS A CA  1 
ATOM   1743 C C   . LYS A 1 248 ? -15.327 -38.350 10.396  1.00 56.16  ?  242 LYS A C   1 
ATOM   1744 O O   . LYS A 1 248 ? -14.431 -39.074 9.944   1.00 53.45  ?  242 LYS A O   1 
ATOM   1745 C CB  . LYS A 1 248 ? -16.833 -38.017 8.410   1.00 51.91  ?  242 LYS A CB  1 
ATOM   1746 C CG  . LYS A 1 248 ? -17.990 -38.834 8.909   1.00 54.90  ?  242 LYS A CG  1 
ATOM   1747 C CD  . LYS A 1 248 ? -18.747 -39.532 7.752   1.00 59.56  ?  242 LYS A CD  1 
ATOM   1748 C CE  . LYS A 1 248 ? -17.836 -40.381 6.857   1.00 57.47  ?  242 LYS A CE  1 
ATOM   1749 N NZ  . LYS A 1 248 ? -17.554 -41.706 7.446   1.00 56.61  ?  242 LYS A NZ  1 
ATOM   1750 N N   . GLY A 1 249 ? -15.736 -38.409 11.660  1.00 57.67  ?  243 GLY A N   1 
ATOM   1751 C CA  . GLY A 1 249 ? -15.143 -39.416 12.512  1.00 54.93  ?  243 GLY A CA  1 
ATOM   1752 C C   . GLY A 1 249 ? -15.917 -39.714 13.779  1.00 56.70  ?  243 GLY A C   1 
ATOM   1753 O O   . GLY A 1 249 ? -17.050 -39.264 13.965  1.00 58.22  ?  243 GLY A O   1 
ATOM   1754 N N   . VAL A 1 250 ? -15.265 -40.473 14.663  1.00 56.10  ?  244 VAL A N   1 
ATOM   1755 C CA  . VAL A 1 250 ? -15.856 -40.992 15.894  1.00 54.44  ?  244 VAL A CA  1 
ATOM   1756 C C   . VAL A 1 250 ? -15.359 -40.160 17.075  1.00 55.86  ?  244 VAL A C   1 
ATOM   1757 O O   . VAL A 1 250 ? -14.149 -39.970 17.240  1.00 54.50  ?  244 VAL A O   1 
ATOM   1758 C CB  . VAL A 1 250 ? -15.484 -42.479 16.099  1.00 59.79  ?  244 VAL A CB  1 
ATOM   1759 C CG1 . VAL A 1 250 ? -16.156 -43.042 17.362  1.00 53.12  ?  244 VAL A CG1 1 
ATOM   1760 C CG2 . VAL A 1 250 ? -15.742 -43.344 14.834  1.00 47.74  ?  244 VAL A CG2 1 
ATOM   1761 N N   . SER A 1 251 ? -16.281 -39.674 17.907  1.00 58.09  ?  245 SER A N   1 
ATOM   1762 C CA  . SER A 1 251 ? -15.940 -39.117 19.217  1.00 55.35  ?  245 SER A CA  1 
ATOM   1763 C C   . SER A 1 251 ? -16.205 -40.194 20.269  1.00 61.28  ?  245 SER A C   1 
ATOM   1764 O O   . SER A 1 251 ? -17.359 -40.610 20.454  1.00 55.62  ?  245 SER A O   1 
ATOM   1765 C CB  . SER A 1 251 ? -16.757 -37.862 19.533  1.00 53.47  ?  245 SER A CB  1 
ATOM   1766 O OG  . SER A 1 251 ? -16.539 -36.827 18.585  1.00 57.98  ?  245 SER A OG  1 
ATOM   1767 N N   . GLY A 1 252 ? -15.145 -40.650 20.952  1.00 59.40  ?  246 GLY A N   1 
ATOM   1768 C CA  . GLY A 1 252 ? -15.291 -41.796 21.845  1.00 59.74  ?  246 GLY A CA  1 
ATOM   1769 C C   . GLY A 1 252 ? -15.716 -43.047 21.092  1.00 57.32  ?  246 GLY A C   1 
ATOM   1770 O O   . GLY A 1 252 ? -14.875 -43.741 20.516  1.00 56.30  ?  246 GLY A O   1 
ATOM   1771 N N   . GLN A 1 253 ? -17.020 -43.334 21.059  1.00 54.49  ?  247 GLN A N   1 
ATOM   1772 C CA  . GLN A 1 253 ? -17.544 -44.443 20.268  1.00 57.58  ?  247 GLN A CA  1 
ATOM   1773 C C   . GLN A 1 253 ? -18.691 -44.050 19.339  1.00 59.70  ?  247 GLN A C   1 
ATOM   1774 O O   . GLN A 1 253 ? -19.115 -44.882 18.523  1.00 58.29  ?  247 GLN A O   1 
ATOM   1775 C CB  . GLN A 1 253 ? -17.989 -45.584 21.193  1.00 55.18  ?  247 GLN A CB  1 
ATOM   1776 C CG  . GLN A 1 253 ? -16.812 -46.377 21.715  1.00 57.47  ?  247 GLN A CG  1 
ATOM   1777 C CD  . GLN A 1 253 ? -17.183 -47.295 22.868  1.00 65.83  ?  247 GLN A CD  1 
ATOM   1778 O OE1 . GLN A 1 253 ? -18.251 -47.142 23.467  1.00 62.60  ?  247 GLN A OE1 1 
ATOM   1779 N NE2 . GLN A 1 253 ? -16.304 -48.274 23.175  1.00 56.84  ?  247 GLN A NE2 1 
ATOM   1780 N N   . THR A 1 254 ? -19.183 -42.811 19.427  1.00 55.07  ?  248 THR A N   1 
ATOM   1781 C CA  . THR A 1 254 ? -20.244 -42.290 18.580  1.00 51.52  ?  248 THR A CA  1 
ATOM   1782 C C   . THR A 1 254 ? -19.732 -41.919 17.188  1.00 55.47  ?  248 THR A C   1 
ATOM   1783 O O   . THR A 1 254 ? -18.817 -41.096 17.052  1.00 58.37  ?  248 THR A O   1 
ATOM   1784 C CB  . THR A 1 254 ? -20.830 -41.052 19.244  1.00 55.27  ?  248 THR A CB  1 
ATOM   1785 O OG1 . THR A 1 254 ? -21.347 -41.396 20.534  1.00 59.38  ?  248 THR A OG1 1 
ATOM   1786 C CG2 . THR A 1 254 ? -21.912 -40.481 18.416  1.00 53.73  ?  248 THR A CG2 1 
ATOM   1787 N N   . GLN A 1 255 ? -20.357 -42.481 16.158  1.00 54.76  ?  249 GLN A N   1 
ATOM   1788 C CA  . GLN A 1 255 ? -19.999 -42.238 14.767  1.00 49.91  ?  249 GLN A CA  1 
ATOM   1789 C C   . GLN A 1 255 ? -20.674 -40.989 14.216  1.00 51.91  ?  249 GLN A C   1 
ATOM   1790 O O   . GLN A 1 255 ? -21.558 -40.395 14.839  1.00 52.10  ?  249 GLN A O   1 
ATOM   1791 C CB  . GLN A 1 255 ? -20.404 -43.421 13.896  1.00 53.49  ?  249 GLN A CB  1 
ATOM   1792 C CG  . GLN A 1 255 ? -20.357 -44.743 14.612  1.00 55.90  ?  249 GLN A CG  1 
ATOM   1793 C CD  . GLN A 1 255 ? -18.998 -45.360 14.510  1.00 52.53  ?  249 GLN A CD  1 
ATOM   1794 O OE1 . GLN A 1 255 ? -18.464 -45.557 13.410  1.00 51.69  ?  249 GLN A OE1 1 
ATOM   1795 N NE2 . GLN A 1 255 ? -18.403 -45.626 15.653  1.00 47.88  ?  249 GLN A NE2 1 
ATOM   1796 N N   . ASN A 1 256 ? -20.245 -40.607 13.009  1.00 54.27  ?  250 ASN A N   1 
ATOM   1797 C CA  . ASN A 1 256 ? -20.927 -39.608 12.184  1.00 59.32  ?  250 ASN A CA  1 
ATOM   1798 C C   . ASN A 1 256 ? -20.770 -38.191 12.727  1.00 57.21  ?  250 ASN A C   1 
ATOM   1799 O O   . ASN A 1 256 ? -21.637 -37.333 12.529  1.00 56.62  ?  250 ASN A O   1 
ATOM   1800 C CB  . ASN A 1 256 ? -22.413 -39.938 12.009  1.00 51.28  ?  250 ASN A CB  1 
ATOM   1801 C CG  . ASN A 1 256 ? -22.987 -39.319 10.762  1.00 56.76  ?  250 ASN A CG  1 
ATOM   1802 O OD1 . ASN A 1 256 ? -22.330 -39.307 9.716   1.00 60.45  ?  250 ASN A OD1 1 
ATOM   1803 N ND2 . ASN A 1 256 ? -24.216 -38.790 10.858  1.00 51.84  ?  250 ASN A ND2 1 
ATOM   1804 N N   . GLN A 1 257 ? -19.674 -37.935 13.420  1.00 53.73  ?  251 GLN A N   1 
ATOM   1805 C CA  . GLN A 1 257 ? -19.316 -36.577 13.806  1.00 56.07  ?  251 GLN A CA  1 
ATOM   1806 C C   . GLN A 1 257 ? -18.763 -35.817 12.590  1.00 52.73  ?  251 GLN A C   1 
ATOM   1807 O O   . GLN A 1 257 ? -17.820 -36.281 11.941  1.00 54.67  ?  251 GLN A O   1 
ATOM   1808 C CB  . GLN A 1 257 ? -18.309 -36.661 14.950  1.00 55.89  ?  251 GLN A CB  1 
ATOM   1809 C CG  . GLN A 1 257 ? -18.870 -37.428 16.157  1.00 54.08  ?  251 GLN A CG  1 
ATOM   1810 C CD  . GLN A 1 257 ? -19.843 -36.569 16.982  1.00 57.76  ?  251 GLN A CD  1 
ATOM   1811 O OE1 . GLN A 1 257 ? -20.959 -36.279 16.541  1.00 55.71  ?  251 GLN A OE1 1 
ATOM   1812 N NE2 . GLN A 1 257 ? -19.400 -36.125 18.173  1.00 54.16  ?  251 GLN A NE2 1 
ATOM   1813 N N   . LEU A 1 258 ? -19.349 -34.665 12.261  1.00 52.23  ?  252 LEU A N   1 
ATOM   1814 C CA  . LEU A 1 258 ? -19.013 -33.951 11.031  1.00 56.12  ?  252 LEU A CA  1 
ATOM   1815 C C   . LEU A 1 258 ? -18.396 -32.587 11.328  1.00 59.08  ?  252 LEU A C   1 
ATOM   1816 O O   . LEU A 1 258 ? -18.989 -31.776 12.050  1.00 54.45  ?  252 LEU A O   1 
ATOM   1817 C CB  . LEU A 1 258 ? -20.249 -33.763 10.148  1.00 51.92  ?  252 LEU A CB  1 
ATOM   1818 C CG  . LEU A 1 258 ? -21.203 -34.950 10.134  1.00 60.15  ?  252 LEU A CG  1 
ATOM   1819 C CD1 . LEU A 1 258 ? -22.550 -34.517 9.584   1.00 64.25  ?  252 LEU A CD1 1 
ATOM   1820 C CD2 . LEU A 1 258 ? -20.604 -36.092 9.301   1.00 56.28  ?  252 LEU A CD2 1 
ATOM   1821 N N   . PHE A 1 259 ? -17.237 -32.324 10.710  1.00 58.05  ?  253 PHE A N   1 
ATOM   1822 C CA  . PHE A 1 259 ? -16.461 -31.107 10.901  1.00 56.50  ?  253 PHE A CA  1 
ATOM   1823 C C   . PHE A 1 259 ? -16.060 -30.526 9.555   1.00 59.11  ?  253 PHE A C   1 
ATOM   1824 O O   . PHE A 1 259 ? -15.573 -31.251 8.680   1.00 57.62  ?  253 PHE A O   1 
ATOM   1825 C CB  . PHE A 1 259 ? -15.209 -31.387 11.719  1.00 55.92  ?  253 PHE A CB  1 
ATOM   1826 C CG  . PHE A 1 259 ? -15.485 -32.066 13.023  1.00 59.39  ?  253 PHE A CG  1 
ATOM   1827 C CD1 . PHE A 1 259 ? -15.735 -31.321 14.161  1.00 56.60  ?  253 PHE A CD1 1 
ATOM   1828 C CD2 . PHE A 1 259 ? -15.496 -33.448 13.109  1.00 55.07  ?  253 PHE A CD2 1 
ATOM   1829 C CE1 . PHE A 1 259 ? -15.985 -31.932 15.355  1.00 55.65  ?  253 PHE A CE1 1 
ATOM   1830 C CE2 . PHE A 1 259 ? -15.756 -34.068 14.296  1.00 56.73  ?  253 PHE A CE2 1 
ATOM   1831 C CZ  . PHE A 1 259 ? -16.006 -33.313 15.424  1.00 60.45  ?  253 PHE A CZ  1 
ATOM   1832 N N   . THR A 1 260 ? -16.227 -29.215 9.415   1.00 52.90  ?  254 THR A N   1 
ATOM   1833 C CA  . THR A 1 260 ? -15.899 -28.501 8.189   1.00 58.25  ?  254 THR A CA  1 
ATOM   1834 C C   . THR A 1 260 ? -15.272 -27.153 8.525   1.00 58.72  ?  254 THR A C   1 
ATOM   1835 O O   . THR A 1 260 ? -15.784 -26.405 9.368   1.00 52.48  ?  254 THR A O   1 
ATOM   1836 C CB  . THR A 1 260 ? -17.148 -28.298 7.330   1.00 59.46  ?  254 THR A CB  1 
ATOM   1837 O OG1 . THR A 1 260 ? -17.567 -29.562 6.816   1.00 64.35  ?  254 THR A OG1 1 
ATOM   1838 C CG2 . THR A 1 260 ? -16.863 -27.373 6.172   1.00 61.90  ?  254 THR A CG2 1 
ATOM   1839 N N   . TYR A 1 261 ? -14.160 -26.855 7.863   1.00 54.82  ?  255 TYR A N   1 
ATOM   1840 C CA  . TYR A 1 261 ? -13.438 -25.603 8.045   1.00 57.35  ?  255 TYR A CA  1 
ATOM   1841 C C   . TYR A 1 261 ? -13.079 -25.057 6.679   1.00 54.69  ?  255 TYR A C   1 
ATOM   1842 O O   . TYR A 1 261 ? -12.472 -25.762 5.869   1.00 61.15  ?  255 TYR A O   1 
ATOM   1843 C CB  . TYR A 1 261 ? -12.158 -25.795 8.856   1.00 55.62  ?  255 TYR A CB  1 
ATOM   1844 C CG  . TYR A 1 261 ? -11.392 -24.520 8.989   1.00 54.75  ?  255 TYR A CG  1 
ATOM   1845 C CD1 . TYR A 1 261 ? -11.807 -23.557 9.883   1.00 58.61  ?  255 TYR A CD1 1 
ATOM   1846 C CD2 . TYR A 1 261 ? -10.274 -24.251 8.199   1.00 57.32  ?  255 TYR A CD2 1 
ATOM   1847 C CE1 . TYR A 1 261 ? -11.127 -22.368 10.021  1.00 60.18  ?  255 TYR A CE1 1 
ATOM   1848 C CE2 . TYR A 1 261 ? -9.572  -23.045 8.328   1.00 59.03  ?  255 TYR A CE2 1 
ATOM   1849 C CZ  . TYR A 1 261 ? -10.011 -22.114 9.247   1.00 65.37  ?  255 TYR A CZ  1 
ATOM   1850 O OH  . TYR A 1 261 ? -9.369  -20.909 9.415   1.00 68.22  ?  255 TYR A OH  1 
ATOM   1851 N N   . GLU A 1 262 ? -13.425 -23.808 6.435   1.00 53.81  ?  256 GLU A N   1 
ATOM   1852 C CA  . GLU A 1 262 ? -13.198 -23.197 5.135   1.00 58.07  ?  256 GLU A CA  1 
ATOM   1853 C C   . GLU A 1 262 ? -12.713 -21.761 5.301   1.00 59.53  ?  256 GLU A C   1 
ATOM   1854 O O   . GLU A 1 262 ? -13.169 -21.046 6.202   1.00 59.58  ?  256 GLU A O   1 
ATOM   1855 C CB  . GLU A 1 262 ? -14.481 -23.278 4.304   1.00 63.70  ?  256 GLU A CB  1 
ATOM   1856 C CG  . GLU A 1 262 ? -14.247 -23.274 2.809   1.00 72.64  ?  256 GLU A CG  1 
ATOM   1857 C CD  . GLU A 1 262 ? -15.533 -23.453 1.994   1.00 84.16  ?  256 GLU A CD  1 
ATOM   1858 O OE1 . GLU A 1 262 ? -16.633 -23.677 2.594   1.00 67.43  ?  256 GLU A OE1 1 
ATOM   1859 O OE2 . GLU A 1 262 ? -15.411 -23.365 0.744   1.00 87.21  -1 256 GLU A OE2 1 
ATOM   1860 N N   . MET A 1 263 ? -11.758 -21.354 4.458   1.00 55.61  ?  257 MET A N   1 
ATOM   1861 C CA  . MET A 1 263 ? -11.329 -19.963 4.385   1.00 55.81  ?  257 MET A CA  1 
ATOM   1862 C C   . MET A 1 263 ? -11.256 -19.510 2.939   1.00 58.60  ?  257 MET A C   1 
ATOM   1863 O O   . MET A 1 263 ? -10.843 -20.261 2.052   1.00 58.43  ?  257 MET A O   1 
ATOM   1864 C CB  . MET A 1 263 ? -9.962  -19.677 5.064   1.00 53.78  ?  257 MET A CB  1 
ATOM   1865 C CG  . MET A 1 263 ? -9.050  -20.836 5.283   1.00 63.19  ?  257 MET A CG  1 
ATOM   1866 S SD  . MET A 1 263 ? -7.380  -20.377 5.852   1.00 70.21  ?  257 MET A SD  1 
ATOM   1867 C CE  . MET A 1 263 ? -7.737  -19.875 7.501   1.00 62.93  ?  257 MET A CE  1 
ATOM   1868 N N   . ARG A 1 264 ? -11.685 -18.279 2.715   1.00 58.01  ?  258 ARG A N   1 
ATOM   1869 C CA  . ARG A 1 264 ? -11.441 -17.566 1.471   1.00 60.82  ?  258 ARG A CA  1 
ATOM   1870 C C   . ARG A 1 264 ? -10.598 -16.356 1.857   1.00 59.08  ?  258 ARG A C   1 
ATOM   1871 O O   . ARG A 1 264 ? -11.087 -15.442 2.533   1.00 58.14  ?  258 ARG A O   1 
ATOM   1872 C CB  . ARG A 1 264 ? -12.761 -17.169 0.807   1.00 58.81  ?  258 ARG A CB  1 
ATOM   1873 C CG  . ARG A 1 264 ? -13.498 -18.319 0.105   1.00 62.49  ?  258 ARG A CG  1 
ATOM   1874 C CD  . ARG A 1 264 ? -14.950 -18.340 0.595   1.00 78.85  ?  258 ARG A CD  1 
ATOM   1875 N NE  . ARG A 1 264 ? -14.934 -18.361 2.062   1.00 82.48  ?  258 ARG A NE  1 
ATOM   1876 C CZ  . ARG A 1 264 ? -15.844 -18.928 2.842   1.00 70.37  ?  258 ARG A CZ  1 
ATOM   1877 N NH1 . ARG A 1 264 ? -16.936 -19.480 2.336   1.00 77.74  ?  258 ARG A NH1 1 
ATOM   1878 N NH2 . ARG A 1 264 ? -15.651 -18.929 4.160   1.00 54.26  ?  258 ARG A NH2 1 
ATOM   1879 N N   . ILE A 1 265 ? -9.323  -16.353 1.478   1.00 54.30  ?  259 ILE A N   1 
ATOM   1880 C CA  . ILE A 1 265 ? -8.394  -15.388 2.050   1.00 54.89  ?  259 ILE A CA  1 
ATOM   1881 C C   . ILE A 1 265 ? -7.363  -14.927 1.024   1.00 57.51  ?  259 ILE A C   1 
ATOM   1882 O O   . ILE A 1 265 ? -7.113  -15.591 0.010   1.00 56.13  ?  259 ILE A O   1 
ATOM   1883 C CB  . ILE A 1 265 ? -7.672  -15.976 3.287   1.00 51.61  ?  259 ILE A CB  1 
ATOM   1884 C CG1 . ILE A 1 265 ? -7.107  -17.364 2.978   1.00 60.96  ?  259 ILE A CG1 1 
ATOM   1885 C CG2 . ILE A 1 265 ? -8.597  -16.085 4.471   1.00 53.05  ?  259 ILE A CG2 1 
ATOM   1886 C CD1 . ILE A 1 265 ? -5.656  -17.364 2.528   1.00 55.50  ?  259 ILE A CD1 1 
ATOM   1887 N N   . ASN A 1 266 ? -6.747  -13.769 1.321   1.00 53.95  ?  260 ASN A N   1 
ATOM   1888 C CA  . ASN A 1 266 ? -5.480  -13.365 0.700   1.00 53.95  ?  260 ASN A CA  1 
ATOM   1889 C C   . ASN A 1 266 ? -4.362  -14.232 1.273   1.00 53.02  ?  260 ASN A C   1 
ATOM   1890 O O   . ASN A 1 266 ? -4.051  -14.149 2.469   1.00 49.78  ?  260 ASN A O   1 
ATOM   1891 C CB  . ASN A 1 266 ? -5.207  -11.887 0.966   1.00 48.01  ?  260 ASN A CB  1 
ATOM   1892 C CG  . ASN A 1 266 ? -3.996  -11.334 0.174   1.00 57.57  ?  260 ASN A CG  1 
ATOM   1893 O OD1 . ASN A 1 266 ? -2.972  -12.009 -0.024  1.00 53.61  ?  260 ASN A OD1 1 
ATOM   1894 N ND2 . ASN A 1 266 ? -4.107  -10.080 -0.249  1.00 58.54  ?  260 ASN A ND2 1 
ATOM   1895 N N   . ASN A 1 267 ? -3.751  -15.065 0.431   1.00 53.67  ?  261 ASN A N   1 
ATOM   1896 C CA  . ASN A 1 267 ? -2.802  -16.046 0.955   1.00 47.92  ?  261 ASN A CA  1 
ATOM   1897 C C   . ASN A 1 267 ? -1.574  -15.384 1.555   1.00 53.99  ?  261 ASN A C   1 
ATOM   1898 O O   . ASN A 1 267 ? -1.238  -15.693 2.715   1.00 52.69  ?  261 ASN A O   1 
ATOM   1899 C CB  . ASN A 1 267 ? -2.431  -17.048 -0.133  1.00 55.75  ?  261 ASN A CB  1 
ATOM   1900 C CG  . ASN A 1 267 ? -1.653  -18.230 0.404   1.00 57.87  ?  261 ASN A CG  1 
ATOM   1901 O OD1 . ASN A 1 267 ? -1.836  -18.653 1.545   1.00 58.34  ?  261 ASN A OD1 1 
ATOM   1902 N ND2 . ASN A 1 267 ? -0.799  -18.781 -0.428  1.00 60.33  ?  261 ASN A ND2 1 
ATOM   1903 N N   . PRO A 1 268 ? -0.864  -14.483 0.859   1.00 54.85  ?  262 PRO A N   1 
ATOM   1904 C CA  . PRO A 1 268 ? 0.297   -13.856 1.514   1.00 53.42  ?  262 PRO A CA  1 
ATOM   1905 C C   . PRO A 1 268 ? -0.092  -12.991 2.688   1.00 50.30  ?  262 PRO A C   1 
ATOM   1906 O O   . PRO A 1 268 ? 0.661   -12.922 3.665   1.00 52.37  ?  262 PRO A O   1 
ATOM   1907 C CB  . PRO A 1 268 ? 0.973   -13.050 0.397   1.00 49.65  ?  262 PRO A CB  1 
ATOM   1908 C CG  . PRO A 1 268 ? 0.044   -13.097 -0.770  1.00 55.59  ?  262 PRO A CG  1 
ATOM   1909 C CD  . PRO A 1 268 ? -0.929  -14.187 -0.589  1.00 49.89  ?  262 PRO A CD  1 
ATOM   1910 N N   . ALA A 1 269 ? -1.243  -12.328 2.638   1.00 52.44  ?  263 ALA A N   1 
ATOM   1911 C CA  . ALA A 1 269 ? -1.664  -11.559 3.799   1.00 50.93  ?  263 ALA A CA  1 
ATOM   1912 C C   . ALA A 1 269 ? -1.822  -12.461 5.017   1.00 51.51  ?  263 ALA A C   1 
ATOM   1913 O O   . ALA A 1 269 ? -1.370  -12.117 6.114   1.00 51.16  ?  263 ALA A O   1 
ATOM   1914 C CB  . ALA A 1 269 ? -2.958  -10.811 3.496   1.00 50.75  ?  263 ALA A CB  1 
ATOM   1915 N N   . LEU A 1 270 ? -2.437  -13.634 4.838   1.00 53.12  ?  264 LEU A N   1 
ATOM   1916 C CA  . LEU A 1 270 ? -2.616  -14.561 5.952   1.00 50.29  ?  264 LEU A CA  1 
ATOM   1917 C C   . LEU A 1 270 ? -1.276  -15.070 6.449   1.00 52.43  ?  264 LEU A C   1 
ATOM   1918 O O   . LEU A 1 270 ? -0.939  -14.936 7.638   1.00 45.62  ?  264 LEU A O   1 
ATOM   1919 C CB  . LEU A 1 270 ? -3.478  -15.744 5.525   1.00 54.44  ?  264 LEU A CB  1 
ATOM   1920 C CG  . LEU A 1 270 ? -3.968  -16.589 6.696   1.00 54.13  ?  264 LEU A CG  1 
ATOM   1921 C CD1 . LEU A 1 270 ? -4.532  -15.674 7.812   1.00 51.43  ?  264 LEU A CD1 1 
ATOM   1922 C CD2 . LEU A 1 270 ? -4.976  -17.628 6.199   1.00 51.68  ?  264 LEU A CD2 1 
ATOM   1923 N N   . THR A 1 271 ? -0.499  -15.659 5.535   1.00 50.19  ?  265 THR A N   1 
ATOM   1924 C CA  . THR A 1 271 ? 0.762   -16.270 5.921   1.00 51.44  ?  265 THR A CA  1 
ATOM   1925 C C   . THR A 1 271 ? 1.618   -15.291 6.716   1.00 54.82  ?  265 THR A C   1 
ATOM   1926 O O   . THR A 1 271 ? 2.149   -15.632 7.781   1.00 56.53  ?  265 THR A O   1 
ATOM   1927 C CB  . THR A 1 271 ? 1.506   -16.762 4.686   1.00 55.94  ?  265 THR A CB  1 
ATOM   1928 O OG1 . THR A 1 271 ? 0.816   -17.890 4.118   1.00 54.71  ?  265 THR A OG1 1 
ATOM   1929 C CG2 . THR A 1 271 ? 2.926   -17.163 5.076   1.00 54.01  ?  265 THR A CG2 1 
ATOM   1930 N N   . SER A 1 272 ? 1.717   -14.047 6.248   1.00 50.74  ?  266 SER A N   1 
ATOM   1931 C CA  . SER A 1 272 ? 2.566   -13.102 6.961   1.00 51.24  ?  266 SER A CA  1 
ATOM   1932 C C   . SER A 1 272 ? 1.936   -12.670 8.271   1.00 47.57  ?  266 SER A C   1 
ATOM   1933 O O   . SER A 1 272 ? 2.650   -12.386 9.232   1.00 53.19  ?  266 SER A O   1 
ATOM   1934 C CB  . SER A 1 272 ? 2.874   -11.887 6.090   1.00 53.00  ?  266 SER A CB  1 
ATOM   1935 O OG  . SER A 1 272 ? 1.697   -11.193 5.721   1.00 53.34  ?  266 SER A OG  1 
ATOM   1936 N N   . GLN A 1 273 ? 0.615   -12.624 8.345   1.00 46.74  ?  267 GLN A N   1 
ATOM   1937 C CA  . GLN A 1 273 ? -0.012  -12.272 9.610   1.00 45.18  ?  267 GLN A CA  1 
ATOM   1938 C C   . GLN A 1 273 ? 0.206   -13.369 10.643  1.00 49.25  ?  267 GLN A C   1 
ATOM   1939 O O   . GLN A 1 273 ? 0.490   -13.084 11.812  1.00 52.21  ?  267 GLN A O   1 
ATOM   1940 C CB  . GLN A 1 273 ? -1.492  -12.008 9.379   1.00 47.44  ?  267 GLN A CB  1 
ATOM   1941 C CG  . GLN A 1 273 ? -2.322  -11.855 10.627  1.00 49.21  ?  267 GLN A CG  1 
ATOM   1942 C CD  . GLN A 1 273 ? -1.996  -10.584 11.371  1.00 49.13  ?  267 GLN A CD  1 
ATOM   1943 O OE1 . GLN A 1 273 ? -2.514  -9.515  11.049  1.00 55.55  ?  267 GLN A OE1 1 
ATOM   1944 N NE2 . GLN A 1 273 ? -1.175  -10.690 12.377  1.00 47.21  ?  267 GLN A NE2 1 
ATOM   1945 N N   . VAL A 1 274 ? 0.113   -14.632 10.219  1.00 50.50  ?  268 VAL A N   1 
ATOM   1946 C CA  . VAL A 1 274 ? 0.407   -15.753 11.104  1.00 48.91  ?  268 VAL A CA  1 
ATOM   1947 C C   . VAL A 1 274 ? 1.870   -15.702 11.551  1.00 55.55  ?  268 VAL A C   1 
ATOM   1948 O O   . VAL A 1 274 ? 2.215   -16.031 12.701  1.00 50.80  ?  268 VAL A O   1 
ATOM   1949 C CB  . VAL A 1 274 ? 0.066   -17.075 10.389  1.00 53.28  ?  268 VAL A CB  1 
ATOM   1950 C CG1 . VAL A 1 274 ? 0.547   -18.272 11.190  1.00 53.31  ?  268 VAL A CG1 1 
ATOM   1951 C CG2 . VAL A 1 274 ? -1.440  -17.174 10.095  1.00 45.16  ?  268 VAL A CG2 1 
ATOM   1952 N N   . MET A 1 275 ? 2.752   -15.261 10.662  1.00 52.97  ?  269 MET A N   1 
ATOM   1953 C CA  . MET A 1 275 ? 4.155   -15.231 11.035  1.00 51.82  ?  269 MET A CA  1 
ATOM   1954 C C   . MET A 1 275 ? 4.411   -14.147 12.085  1.00 55.78  ?  269 MET A C   1 
ATOM   1955 O O   . MET A 1 275 ? 5.200   -14.352 13.022  1.00 55.71  ?  269 MET A O   1 
ATOM   1956 C CB  . MET A 1 275 ? 5.009   -15.003 9.800   1.00 53.37  ?  269 MET A CB  1 
ATOM   1957 C CG  . MET A 1 275 ? 5.289   -16.252 8.983   1.00 52.35  ?  269 MET A CG  1 
ATOM   1958 S SD  . MET A 1 275 ? 5.740   -15.814 7.300   1.00 60.78  ?  269 MET A SD  1 
ATOM   1959 C CE  . MET A 1 275 ? 7.485   -16.128 7.486   1.00 55.31  ?  269 MET A CE  1 
ATOM   1960 N N   . ILE A 1 276 ? 3.725   -13.001 11.962  1.00 51.33  ?  270 ILE A N   1 
ATOM   1961 C CA  . ILE A 1 276 ? 3.900   -11.907 12.911  1.00 50.91  ?  270 ILE A CA  1 
ATOM   1962 C C   . ILE A 1 276 ? 3.333   -12.294 14.265  1.00 51.75  ?  270 ILE A C   1 
ATOM   1963 O O   . ILE A 1 276 ? 3.917   -11.972 15.307  1.00 49.74  ?  270 ILE A O   1 
ATOM   1964 C CB  . ILE A 1 276 ? 3.255   -10.611 12.366  1.00 55.71  ?  270 ILE A CB  1 
ATOM   1965 C CG1 . ILE A 1 276 ? 4.296   -9.752  11.635  1.00 51.43  ?  270 ILE A CG1 1 
ATOM   1966 C CG2 . ILE A 1 276 ? 2.593   -9.782  13.495  1.00 48.35  ?  270 ILE A CG2 1 
ATOM   1967 C CD1 . ILE A 1 276 ? 5.054   -10.484 10.524  1.00 49.84  ?  270 ILE A CD1 1 
ATOM   1968 N N   . ALA A 1 277 ? 2.190   -12.999 14.275  1.00 54.44  ?  271 ALA A N   1 
ATOM   1969 C CA  . ALA A 1 277 ? 1.646   -13.525 15.530  1.00 51.37  ?  271 ALA A CA  1 
ATOM   1970 C C   . ALA A 1 277 ? 2.581   -14.555 16.138  1.00 51.52  ?  271 ALA A C   1 
ATOM   1971 O O   . ALA A 1 277 ? 2.706   -14.654 17.365  1.00 49.41  ?  271 ALA A O   1 
ATOM   1972 C CB  . ALA A 1 277 ? 0.269   -14.144 15.304  1.00 52.18  ?  271 ALA A CB  1 
ATOM   1973 N N   . SER A 1 278 ? 3.229   -15.350 15.291  1.00 53.88  ?  272 SER A N   1 
ATOM   1974 C CA  . SER A 1 278 ? 4.220   -16.286 15.792  1.00 53.71  ?  272 SER A CA  1 
ATOM   1975 C C   . SER A 1 278 ? 5.424   -15.553 16.364  1.00 53.12  ?  272 SER A C   1 
ATOM   1976 O O   . SER A 1 278 ? 6.029   -16.032 17.338  1.00 47.66  ?  272 SER A O   1 
ATOM   1977 C CB  . SER A 1 278 ? 4.644   -17.249 14.677  1.00 52.08  ?  272 SER A CB  1 
ATOM   1978 O OG  . SER A 1 278 ? 3.568   -18.100 14.304  1.00 48.33  ?  272 SER A OG  1 
ATOM   1979 N N   . ALA A 1 279 ? 5.793   -14.398 15.777  1.00 53.21  ?  273 ALA A N   1 
ATOM   1980 C CA  . ALA A 1 279 ? 6.888   -13.611 16.350  1.00 50.74  ?  273 ALA A CA  1 
ATOM   1981 C C   . ALA A 1 279 ? 6.562   -13.239 17.784  1.00 55.40  ?  273 ALA A C   1 
ATOM   1982 O O   . ALA A 1 279 ? 7.412   -13.352 18.673  1.00 55.24  ?  273 ALA A O   1 
ATOM   1983 C CB  . ALA A 1 279 ? 7.156   -12.352 15.527  1.00 48.65  ?  273 ALA A CB  1 
ATOM   1984 N N   . ARG A 1 280 ? 5.313   -12.827 18.027  1.00 53.95  ?  274 ARG A N   1 
ATOM   1985 C CA  . ARG A 1 280 ? 4.866   -12.537 19.381  1.00 52.09  ?  274 ARG A CA  1 
ATOM   1986 C C   . ARG A 1 280 ? 5.036   -13.752 20.280  1.00 53.20  ?  274 ARG A C   1 
ATOM   1987 O O   . ARG A 1 280 ? 5.430   -13.618 21.443  1.00 58.08  ?  274 ARG A O   1 
ATOM   1988 C CB  . ARG A 1 280 ? 3.410   -12.075 19.347  1.00 49.19  ?  274 ARG A CB  1 
ATOM   1989 C CG  . ARG A 1 280 ? 2.744   -12.017 20.692  1.00 51.98  ?  274 ARG A CG  1 
ATOM   1990 C CD  . ARG A 1 280 ? 1.313   -11.482 20.591  1.00 56.98  ?  274 ARG A CD  1 
ATOM   1991 N NE  . ARG A 1 280 ? 1.211   -10.280 19.763  1.00 60.21  ?  274 ARG A NE  1 
ATOM   1992 C CZ  . ARG A 1 280 ? 0.648   -10.249 18.561  1.00 54.04  ?  274 ARG A CZ  1 
ATOM   1993 N NH1 . ARG A 1 280 ? 0.107   -11.326 18.028  1.00 52.33  ?  274 ARG A NH1 1 
ATOM   1994 N NH2 . ARG A 1 280 ? 0.660   -9.119  17.865  1.00 53.32  ?  274 ARG A NH2 1 
ATOM   1995 N N   . ALA A 1 281 ? 4.757   -14.952 19.759  1.00 50.96  ?  275 ALA A N   1 
ATOM   1996 C CA  . ALA A 1 281 ? 4.839   -16.149 20.599  1.00 53.11  ?  275 ALA A CA  1 
ATOM   1997 C C   . ALA A 1 281 ? 6.288   -16.511 20.893  1.00 59.30  ?  275 ALA A C   1 
ATOM   1998 O O   . ALA A 1 281 ? 6.614   -16.947 22.009  1.00 56.10  ?  275 ALA A O   1 
ATOM   1999 C CB  . ALA A 1 281 ? 4.135   -17.329 19.937  1.00 46.99  ?  275 ALA A CB  1 
ATOM   2000 N N   . ALA A 1 282 ? 7.162   -16.334 19.896  1.00 52.08  ?  276 ALA A N   1 
ATOM   2001 C CA  . ALA A 1 282 ? 8.571   -16.661 20.052  1.00 54.63  ?  276 ALA A CA  1 
ATOM   2002 C C   . ALA A 1 282 ? 9.168   -16.009 21.297  1.00 53.97  ?  276 ALA A C   1 
ATOM   2003 O O   . ALA A 1 282 ? 9.905   -16.650 22.055  1.00 59.96  ?  276 ALA A O   1 
ATOM   2004 C CB  . ALA A 1 282 ? 9.332   -16.233 18.801  1.00 54.58  ?  276 ALA A CB  1 
ATOM   2005 N N   . MET A 1 283 ? 8.826   -14.756 21.547  1.00 54.92  ?  277 MET A N   1 
ATOM   2006 C CA  . MET A 1 283 ? 9.279   -14.004 22.711  1.00 55.22  ?  277 MET A CA  1 
ATOM   2007 C C   . MET A 1 283 ? 8.813   -14.608 24.026  1.00 60.07  ?  277 MET A C   1 
ATOM   2008 O O   . MET A 1 283 ? 9.168   -14.074 25.082  1.00 62.35  ?  277 MET A O   1 
ATOM   2009 C CB  . MET A 1 283 ? 8.762   -12.565 22.610  1.00 52.81  ?  277 MET A CB  1 
ATOM   2010 C CG  . MET A 1 283 ? 9.371   -11.736 21.448  1.00 54.24  ?  277 MET A CG  1 
ATOM   2011 S SD  . MET A 1 283 ? 11.183  -11.607 21.431  1.00 58.91  ?  277 MET A SD  1 
ATOM   2012 C CE  . MET A 1 283 ? 11.366  -10.311 22.643  1.00 41.00  ?  277 MET A CE  1 
ATOM   2013 N N   . ARG A 1 284 ? 8.032   -15.695 24.001  1.00 57.85  ?  278 ARG A N   1 
ATOM   2014 C CA  . ARG A 1 284 ? 7.453   -16.248 25.214  1.00 56.50  ?  278 ARG A CA  1 
ATOM   2015 C C   . ARG A 1 284 ? 7.920   -17.664 25.501  1.00 58.57  ?  278 ARG A C   1 
ATOM   2016 O O   . ARG A 1 284 ? 7.721   -18.142 26.624  1.00 62.85  ?  278 ARG A O   1 
ATOM   2017 C CB  . ARG A 1 284 ? 5.917   -16.226 25.137  1.00 55.41  ?  278 ARG A CB  1 
ATOM   2018 C CG  . ARG A 1 284 ? 5.371   -14.907 24.644  1.00 54.60  ?  278 ARG A CG  1 
ATOM   2019 C CD  . ARG A 1 284 ? 3.858   -14.828 24.650  1.00 52.96  ?  278 ARG A CD  1 
ATOM   2020 N NE  . ARG A 1 284 ? 3.443   -13.526 25.169  1.00 58.73  ?  278 ARG A NE  1 
ATOM   2021 C CZ  . ARG A 1 284 ? 2.469   -12.772 24.669  1.00 56.38  ?  278 ARG A CZ  1 
ATOM   2022 N NH1 . ARG A 1 284 ? 1.785   -13.142 23.597  1.00 55.38  ?  278 ARG A NH1 1 
ATOM   2023 N NH2 . ARG A 1 284 ? 2.172   -11.617 25.262  1.00 54.33  ?  278 ARG A NH2 1 
ATOM   2024 N N   . GLN A 1 285 ? 8.545   -18.336 24.540  1.00 54.22  ?  279 GLN A N   1 
ATOM   2025 C CA  . GLN A 1 285 ? 8.932   -19.723 24.691  1.00 53.87  ?  279 GLN A CA  1 
ATOM   2026 C C   . GLN A 1 285 ? 10.312  -19.821 25.335  1.00 62.81  ?  279 GLN A C   1 
ATOM   2027 O O   . GLN A 1 285 ? 11.081  -18.858 25.351  1.00 66.79  ?  279 GLN A O   1 
ATOM   2028 C CB  . GLN A 1 285 ? 8.938   -20.423 23.333  1.00 55.48  ?  279 GLN A CB  1 
ATOM   2029 C CG  . GLN A 1 285 ? 7.659   -20.236 22.523  1.00 56.08  ?  279 GLN A CG  1 
ATOM   2030 C CD  . GLN A 1 285 ? 6.430   -20.431 23.366  1.00 55.31  ?  279 GLN A CD  1 
ATOM   2031 O OE1 . GLN A 1 285 ? 6.168   -21.533 23.845  1.00 58.36  ?  279 GLN A OE1 1 
ATOM   2032 N NE2 . GLN A 1 285 ? 5.671   -19.358 23.571  1.00 57.12  ?  279 GLN A NE2 1 
ATOM   2033 N N   . LYS A 1 286 ? 10.592  -20.992 25.910  1.00 60.47  ?  280 LYS A N   1 
ATOM   2034 C CA  . LYS A 1 286 ? 11.945  -21.396 26.250  1.00 59.20  ?  280 LYS A CA  1 
ATOM   2035 C C   . LYS A 1 286 ? 12.676  -21.702 24.949  1.00 60.40  ?  280 LYS A C   1 
ATOM   2036 O O   . LYS A 1 286 ? 12.029  -21.953 23.930  1.00 59.55  ?  280 LYS A O   1 
ATOM   2037 C CB  . LYS A 1 286 ? 11.939  -22.629 27.172  1.00 58.50  ?  280 LYS A CB  1 
ATOM   2038 C CG  . LYS A 1 286 ? 11.172  -22.482 28.521  1.00 52.44  ?  280 LYS A CG  1 
ATOM   2039 C CD  . LYS A 1 286 ? 11.272  -21.047 29.038  1.00 66.84  ?  280 LYS A CD  1 
ATOM   2040 C CE  . LYS A 1 286 ? 9.900   -20.293 28.885  1.00 75.02  ?  280 LYS A CE  1 
ATOM   2041 N NZ  . LYS A 1 286 ? 9.975   -18.787 29.003  1.00 71.69  ?  280 LYS A NZ  1 
ATOM   2042 N N   . PRO A 1 287 ? 14.021  -21.668 24.949  1.00 60.87  ?  281 PRO A N   1 
ATOM   2043 C CA  . PRO A 1 287 ? 14.769  -21.925 23.702  1.00 58.24  ?  281 PRO A CA  1 
ATOM   2044 C C   . PRO A 1 287 ? 14.414  -23.271 23.088  1.00 56.15  ?  281 PRO A C   1 
ATOM   2045 O O   . PRO A 1 287 ? 14.049  -24.216 23.784  1.00 59.41  ?  281 PRO A O   1 
ATOM   2046 C CB  . PRO A 1 287 ? 16.238  -21.886 24.145  1.00 57.43  ?  281 PRO A CB  1 
ATOM   2047 C CG  . PRO A 1 287 ? 16.244  -21.015 25.359  1.00 58.43  ?  281 PRO A CG  1 
ATOM   2048 C CD  . PRO A 1 287 ? 14.893  -21.158 26.028  1.00 56.83  ?  281 PRO A CD  1 
ATOM   2049 N N   . GLY A 1 288 ? 14.518  -23.345 21.759  1.00 58.12  ?  282 GLY A N   1 
ATOM   2050 C CA  . GLY A 1 288 ? 14.118  -24.529 21.014  1.00 54.52  ?  282 GLY A CA  1 
ATOM   2051 C C   . GLY A 1 288 ? 13.367  -24.216 19.732  1.00 57.29  ?  282 GLY A C   1 
ATOM   2052 O O   . GLY A 1 288 ? 13.078  -23.052 19.443  1.00 56.07  ?  282 GLY A O   1 
ATOM   2053 N N   . ALA A 1 289 ? 13.042  -25.241 18.953  1.00 56.89  ?  283 ALA A N   1 
ATOM   2054 C CA  . ALA A 1 289 ? 12.298  -25.093 17.709  1.00 59.11  ?  283 ALA A CA  1 
ATOM   2055 C C   . ALA A 1 289 ? 10.874  -25.616 17.894  1.00 61.61  ?  283 ALA A C   1 
ATOM   2056 O O   . ALA A 1 289 ? 10.670  -26.676 18.494  1.00 66.29  ?  283 ALA A O   1 
ATOM   2057 C CB  . ALA A 1 289 ? 12.997  -25.853 16.566  1.00 53.86  ?  283 ALA A CB  1 
ATOM   2058 N N   . TYR A 1 290 ? 9.880   -24.895 17.367  1.00 61.16  ?  284 TYR A N   1 
ATOM   2059 C CA  . TYR A 1 290 ? 8.484   -25.272 17.567  1.00 56.36  ?  284 TYR A CA  1 
ATOM   2060 C C   . TYR A 1 290 ? 7.712   -25.224 16.266  1.00 54.13  ?  284 TYR A C   1 
ATOM   2061 O O   . TYR A 1 290 ? 7.902   -24.312 15.456  1.00 55.63  ?  284 TYR A O   1 
ATOM   2062 C CB  . TYR A 1 290 ? 7.785   -24.361 18.547  1.00 51.34  ?  284 TYR A CB  1 
ATOM   2063 C CG  . TYR A 1 290 ? 8.432   -24.279 19.902  1.00 55.51  ?  284 TYR A CG  1 
ATOM   2064 C CD1 . TYR A 1 290 ? 9.458   -23.373 20.148  1.00 50.70  ?  284 TYR A CD1 1 
ATOM   2065 C CD2 . TYR A 1 290 ? 8.001   -25.092 20.948  1.00 52.40  ?  284 TYR A CD2 1 
ATOM   2066 C CE1 . TYR A 1 290 ? 10.042  -23.275 21.393  1.00 54.22  ?  284 TYR A CE1 1 
ATOM   2067 C CE2 . TYR A 1 290 ? 8.580   -25.005 22.209  1.00 52.34  ?  284 TYR A CE2 1 
ATOM   2068 C CZ  . TYR A 1 290 ? 9.604   -24.099 22.423  1.00 61.12  ?  284 TYR A CZ  1 
ATOM   2069 O OH  . TYR A 1 290 ? 10.194  -24.020 23.670  1.00 67.57  ?  284 TYR A OH  1 
ATOM   2070 N N   . THR A 1 291 ? 6.836   -26.205 16.067  1.00 55.23  ?  285 THR A N   1 
ATOM   2071 C CA  . THR A 1 291 ? 5.757   -25.991 15.122  1.00 55.91  ?  285 THR A CA  1 
ATOM   2072 C C   . THR A 1 291 ? 4.613   -25.336 15.878  1.00 54.35  ?  285 THR A C   1 
ATOM   2073 O O   . THR A 1 291 ? 4.650   -25.201 17.102  1.00 53.41  ?  285 THR A O   1 
ATOM   2074 C CB  . THR A 1 291 ? 5.299   -27.285 14.452  1.00 52.84  ?  285 THR A CB  1 
ATOM   2075 O OG1 . THR A 1 291 ? 4.835   -28.199 15.441  1.00 56.29  ?  285 THR A OG1 1 
ATOM   2076 C CG2 . THR A 1 291 ? 6.412   -27.927 13.652  1.00 52.74  ?  285 THR A CG2 1 
ATOM   2077 N N   . MET A 1 292 ? 3.590   -24.918 15.140  1.00 56.25  ?  286 MET A N   1 
ATOM   2078 C CA  . MET A 1 292 ? 2.500   -24.180 15.779  1.00 58.95  ?  286 MET A CA  1 
ATOM   2079 C C   . MET A 1 292 ? 1.614   -25.042 16.681  1.00 52.85  ?  286 MET A C   1 
ATOM   2080 O O   . MET A 1 292 ? 0.825   -24.491 17.458  1.00 53.12  ?  286 MET A O   1 
ATOM   2081 C CB  . MET A 1 292 ? 1.656   -23.490 14.715  1.00 51.55  ?  286 MET A CB  1 
ATOM   2082 C CG  . MET A 1 292 ? 2.430   -22.434 13.910  1.00 47.84  ?  286 MET A CG  1 
ATOM   2083 S SD  . MET A 1 292 ? 1.261   -21.623 12.789  1.00 53.01  ?  286 MET A SD  1 
ATOM   2084 C CE  . MET A 1 292 ? 0.654   -20.395 13.955  1.00 41.44  ?  286 MET A CE  1 
ATOM   2085 N N   . ILE A 1 293 ? 1.718   -26.364 16.630  1.00 52.53  ?  287 ILE A N   1 
ATOM   2086 C CA  . ILE A 1 293 ? 0.890   -27.152 17.532  1.00 52.02  ?  287 ILE A CA  1 
ATOM   2087 C C   . ILE A 1 293 ? 1.633   -27.408 18.839  1.00 53.37  ?  287 ILE A C   1 
ATOM   2088 O O   . ILE A 1 293 ? 1.154   -28.148 19.701  1.00 53.31  ?  287 ILE A O   1 
ATOM   2089 C CB  . ILE A 1 293 ? 0.426   -28.458 16.874  1.00 55.36  ?  287 ILE A CB  1 
ATOM   2090 C CG1 . ILE A 1 293 ? 1.617   -29.347 16.537  1.00 56.30  ?  287 ILE A CG1 1 
ATOM   2091 C CG2 . ILE A 1 293 ? -0.378  -28.167 15.632  1.00 51.72  ?  287 ILE A CG2 1 
ATOM   2092 C CD1 . ILE A 1 293 ? 1.203   -30.667 15.994  1.00 54.39  ?  287 ILE A CD1 1 
ATOM   2093 N N   . GLU A 1 294 ? 2.776   -26.752 19.032  1.00 55.13  ?  288 GLU A N   1 
ATOM   2094 C CA  . GLU A 1 294 ? 3.570   -26.939 20.240  1.00 55.91  ?  288 GLU A CA  1 
ATOM   2095 C C   . GLU A 1 294 ? 3.571   -25.714 21.133  1.00 54.55  ?  288 GLU A C   1 
ATOM   2096 O O   . GLU A 1 294 ? 4.390   -25.635 22.057  1.00 56.72  ?  288 GLU A O   1 
ATOM   2097 C CB  . GLU A 1 294 ? 5.005   -27.317 19.890  1.00 49.73  ?  288 GLU A CB  1 
ATOM   2098 C CG  . GLU A 1 294 ? 5.090   -28.498 18.951  1.00 54.84  ?  288 GLU A CG  1 
ATOM   2099 C CD  . GLU A 1 294 ? 6.507   -28.781 18.526  1.00 58.01  ?  288 GLU A CD  1 
ATOM   2100 O OE1 . GLU A 1 294 ? 7.347   -29.022 19.417  1.00 59.85  ?  288 GLU A OE1 1 
ATOM   2101 O OE2 . GLU A 1 294 ? 6.792   -28.734 17.307  1.00 60.56  -1 288 GLU A OE2 1 
ATOM   2102 N N   . ILE A 1 295 ? 2.666   -24.773 20.889  1.00 51.76  ?  289 ILE A N   1 
ATOM   2103 C CA  . ILE A 1 295 ? 2.590   -23.513 21.619  1.00 53.19  ?  289 ILE A CA  1 
ATOM   2104 C C   . ILE A 1 295 ? 1.151   -23.272 22.072  1.00 52.42  ?  289 ILE A C   1 
ATOM   2105 O O   . ILE A 1 295 ? 0.208   -23.494 21.302  1.00 55.22  ?  289 ILE A O   1 
ATOM   2106 C CB  . ILE A 1 295 ? 3.128   -22.366 20.746  1.00 55.86  ?  289 ILE A CB  1 
ATOM   2107 C CG1 . ILE A 1 295 ? 4.633   -22.545 20.540  1.00 53.25  ?  289 ILE A CG1 1 
ATOM   2108 C CG2 . ILE A 1 295 ? 2.852   -21.006 21.365  1.00 51.91  ?  289 ILE A CG2 1 
ATOM   2109 C CD1 . ILE A 1 295 ? 5.157   -21.723 19.423  1.00 55.29  ?  289 ILE A CD1 1 
ATOM   2110 N N   . PRO A 1 296 ? 0.928   -22.845 23.309  1.00 57.07  ?  290 PRO A N   1 
ATOM   2111 C CA  . PRO A 1 296 ? -0.435  -22.487 23.710  1.00 50.61  ?  290 PRO A CA  1 
ATOM   2112 C C   . PRO A 1 296 ? -0.950  -21.376 22.812  1.00 57.34  ?  290 PRO A C   1 
ATOM   2113 O O   . PRO A 1 296 ? -0.244  -20.391 22.552  1.00 56.00  ?  290 PRO A O   1 
ATOM   2114 C CB  . PRO A 1 296 ? -0.270  -22.004 25.158  1.00 52.65  ?  290 PRO A CB  1 
ATOM   2115 C CG  . PRO A 1 296 ? 1.139   -22.402 25.571  1.00 52.55  ?  290 PRO A CG  1 
ATOM   2116 C CD  . PRO A 1 296 ? 1.929   -22.433 24.313  1.00 52.42  ?  290 PRO A CD  1 
ATOM   2117 N N   . ILE A 1 297 ? -2.187  -21.541 22.333  1.00 49.27  ?  291 ILE A N   1 
ATOM   2118 C CA  . ILE A 1 297 ? -2.777  -20.548 21.442  1.00 51.07  ?  291 ILE A CA  1 
ATOM   2119 C C   . ILE A 1 297 ? -2.703  -19.156 22.057  1.00 52.86  ?  291 ILE A C   1 
ATOM   2120 O O   . ILE A 1 297 ? -2.466  -18.158 21.362  1.00 50.18  ?  291 ILE A O   1 
ATOM   2121 C CB  . ILE A 1 297 ? -4.231  -20.929 21.112  1.00 52.89  ?  291 ILE A CB  1 
ATOM   2122 C CG1 . ILE A 1 297 ? -4.277  -22.171 20.222  1.00 48.61  ?  291 ILE A CG1 1 
ATOM   2123 C CG2 . ILE A 1 297 ? -4.954  -19.755 20.464  1.00 49.97  ?  291 ILE A CG2 1 
ATOM   2124 C CD1 . ILE A 1 297 ? -5.619  -22.855 20.248  1.00 48.42  ?  291 ILE A CD1 1 
ATOM   2125 N N   . ILE A 1 298 ? -2.896  -19.060 23.370  1.00 49.77  ?  292 ILE A N   1 
ATOM   2126 C CA  . ILE A 1 298 ? -2.913  -17.735 23.965  1.00 51.33  ?  292 ILE A CA  1 
ATOM   2127 C C   . ILE A 1 298 ? -1.576  -16.991 23.777  1.00 53.29  ?  292 ILE A C   1 
ATOM   2128 O O   . ILE A 1 298 ? -1.550  -15.757 23.785  1.00 51.41  ?  292 ILE A O   1 
ATOM   2129 C CB  . ILE A 1 298 ? -3.296  -17.854 25.448  1.00 50.95  ?  292 ILE A CB  1 
ATOM   2130 C CG1 . ILE A 1 298 ? -3.863  -16.519 25.934  1.00 48.31  ?  292 ILE A CG1 1 
ATOM   2131 C CG2 . ILE A 1 298 ? -2.062  -18.366 26.264  1.00 50.71  ?  292 ILE A CG2 1 
ATOM   2132 C CD1 . ILE A 1 298 ? -4.294  -16.500 27.394  1.00 55.55  ?  292 ILE A CD1 1 
ATOM   2133 N N   . ASP A 1 299 ? -0.465  -17.712 23.574  1.00 51.66  ?  293 ASP A N   1 
ATOM   2134 C CA  . ASP A 1 299 ? 0.821   -17.049 23.356  1.00 51.17  ?  293 ASP A CA  1 
ATOM   2135 C C   . ASP A 1 299 ? 0.837   -16.234 22.071  1.00 55.35  ?  293 ASP A C   1 
ATOM   2136 O O   . ASP A 1 299 ? 1.578   -15.241 21.976  1.00 53.16  ?  293 ASP A O   1 
ATOM   2137 C CB  . ASP A 1 299 ? 1.954   -18.069 23.322  1.00 49.42  ?  293 ASP A CB  1 
ATOM   2138 C CG  . ASP A 1 299 ? 2.291   -18.603 24.696  1.00 51.82  ?  293 ASP A CG  1 
ATOM   2139 O OD1 . ASP A 1 299 ? 1.772   -18.061 25.697  1.00 54.01  ?  293 ASP A OD1 1 
ATOM   2140 O OD2 . ASP A 1 299 ? 3.066   -19.575 24.778  1.00 57.97  -1 293 ASP A OD2 1 
ATOM   2141 N N   . PHE A 1 300 ? 0.036   -16.633 21.077  1.00 51.35  ?  294 PHE A N   1 
ATOM   2142 C CA  . PHE A 1 300 ? -0.031  -15.912 19.812  1.00 52.81  ?  294 PHE A CA  1 
ATOM   2143 C C   . PHE A 1 300 ? -0.833  -14.618 19.890  1.00 52.08  ?  294 PHE A C   1 
ATOM   2144 O O   . PHE A 1 300 ? -0.815  -13.840 18.929  1.00 51.29  ?  294 PHE A O   1 
ATOM   2145 C CB  . PHE A 1 300 ? -0.647  -16.799 18.732  1.00 50.29  ?  294 PHE A CB  1 
ATOM   2146 C CG  . PHE A 1 300 ? 0.189   -17.996 18.365  1.00 52.20  ?  294 PHE A CG  1 
ATOM   2147 C CD1 . PHE A 1 300 ? 1.239   -17.873 17.466  1.00 53.15  ?  294 PHE A CD1 1 
ATOM   2148 C CD2 . PHE A 1 300 ? -0.096  -19.241 18.888  1.00 51.26  ?  294 PHE A CD2 1 
ATOM   2149 C CE1 . PHE A 1 300 ? 1.987   -18.961 17.114  1.00 52.66  ?  294 PHE A CE1 1 
ATOM   2150 C CE2 . PHE A 1 300 ? 0.650   -20.337 18.533  1.00 52.36  ?  294 PHE A CE2 1 
ATOM   2151 C CZ  . PHE A 1 300 ? 1.689   -20.201 17.652  1.00 51.95  ?  294 PHE A CZ  1 
ATOM   2152 N N   . LEU A 1 301 ? -1.556  -14.373 20.975  1.00 51.67  ?  295 LEU A N   1 
ATOM   2153 C CA  . LEU A 1 301 ? -2.453  -13.231 21.035  1.00 53.04  ?  295 LEU A CA  1 
ATOM   2154 C C   . LEU A 1 301 ? -1.866  -12.091 21.860  1.00 53.83  ?  295 LEU A C   1 
ATOM   2155 O O   . LEU A 1 301 ? -1.241  -12.318 22.898  1.00 54.07  ?  295 LEU A O   1 
ATOM   2156 C CB  . LEU A 1 301 ? -3.805  -13.636 21.621  1.00 52.06  ?  295 LEU A CB  1 
ATOM   2157 C CG  . LEU A 1 301 ? -4.616  -14.620 20.767  1.00 56.86  ?  295 LEU A CG  1 
ATOM   2158 C CD1 . LEU A 1 301 ? -5.435  -15.566 21.659  1.00 50.83  ?  295 LEU A CD1 1 
ATOM   2159 C CD2 . LEU A 1 301 ? -5.507  -13.900 19.760  1.00 46.35  ?  295 LEU A CD2 1 
ATOM   2160 N N   . TYR A 1 302 ? -2.118  -10.861 21.407  1.00 52.22  ?  296 TYR A N   1 
ATOM   2161 C CA  . TYR A 1 302 ? -1.842  -9.665  22.184  1.00 54.62  ?  296 TYR A CA  1 
ATOM   2162 C C   . TYR A 1 302 ? -2.939  -9.431  23.214  1.00 56.01  ?  296 TYR A C   1 
ATOM   2163 O O   . TYR A 1 302 ? -4.121  -9.365  22.872  1.00 60.29  ?  296 TYR A O   1 
ATOM   2164 C CB  . TYR A 1 302 ? -1.724  -8.452  21.257  1.00 53.36  ?  296 TYR A CB  1 
ATOM   2165 C CG  . TYR A 1 302 ? -1.461  -7.145  21.982  1.00 59.80  ?  296 TYR A CG  1 
ATOM   2166 C CD1 . TYR A 1 302 ? -0.238  -6.913  22.603  1.00 62.47  ?  296 TYR A CD1 1 
ATOM   2167 C CD2 . TYR A 1 302 ? -2.428  -6.135  22.047  1.00 59.87  ?  296 TYR A CD2 1 
ATOM   2168 C CE1 . TYR A 1 302 ? 0.025   -5.718  23.284  1.00 57.13  ?  296 TYR A CE1 1 
ATOM   2169 C CE2 . TYR A 1 302 ? -2.163  -4.926  22.721  1.00 63.93  ?  296 TYR A CE2 1 
ATOM   2170 C CZ  . TYR A 1 302 ? -0.917  -4.743  23.336  1.00 61.52  ?  296 TYR A CZ  1 
ATOM   2171 O OH  . TYR A 1 302 ? -0.606  -3.596  24.024  1.00 67.98  ?  296 TYR A OH  1 
ATOM   2172 N N   . GLY A 1 303 ? -2.553  -9.280  24.466  1.00 57.36  ?  297 GLY A N   1 
ATOM   2173 C CA  . GLY A 1 303 ? -3.482  -8.829  25.485  1.00 54.23  ?  297 GLY A CA  1 
ATOM   2174 C C   . GLY A 1 303 ? -3.171  -9.457  26.827  1.00 59.89  ?  297 GLY A C   1 
ATOM   2175 O O   . GLY A 1 303 ? -2.375  -10.393 26.945  1.00 57.53  ?  297 GLY A O   1 
ATOM   2176 N N   . ASP A 1 304 ? -3.827  -8.917  27.855  1.00 62.22  ?  298 ASP A N   1 
ATOM   2177 C CA  . ASP A 1 304 ? -3.815  -9.552  29.166  1.00 62.70  ?  298 ASP A CA  1 
ATOM   2178 C C   . ASP A 1 304 ? -4.420  -10.962 29.101  1.00 63.17  ?  298 ASP A C   1 
ATOM   2179 O O   . ASP A 1 304 ? -5.420  -11.194 28.414  1.00 59.88  ?  298 ASP A O   1 
ATOM   2180 C CB  . ASP A 1 304 ? -4.594  -8.685  30.157  1.00 58.61  ?  298 ASP A CB  1 
ATOM   2181 C CG  . ASP A 1 304 ? -4.424  -9.148  31.596  1.00 70.59  ?  298 ASP A CG  1 
ATOM   2182 O OD1 . ASP A 1 304 ? -3.367  -8.835  32.199  1.00 79.42  -1 298 ASP A OD1 1 
ATOM   2183 O OD2 . ASP A 1 304 ? -5.337  -9.830  32.125  1.00 71.99  ?  298 ASP A OD2 1 
ATOM   2184 N N   . ARG A 1 305 ? -3.808  -11.902 29.833  1.00 59.70  ?  299 ARG A N   1 
ATOM   2185 C CA  . ARG A 1 305 ? -4.319  -13.272 29.931  1.00 59.77  ?  299 ARG A CA  1 
ATOM   2186 C C   . ARG A 1 305 ? -5.800  -13.331 30.323  1.00 63.77  ?  299 ARG A C   1 
ATOM   2187 O O   . ARG A 1 305 ? -6.609  -13.963 29.629  1.00 60.56  ?  299 ARG A O   1 
ATOM   2188 C CB  . ARG A 1 305 ? -3.504  -14.062 30.941  1.00 55.79  ?  299 ARG A CB  1 
ATOM   2189 C CG  . ARG A 1 305 ? -2.161  -14.472 30.435  1.00 65.85  ?  299 ARG A CG  1 
ATOM   2190 C CD  . ARG A 1 305 ? -1.629  -15.688 31.168  1.00 60.34  ?  299 ARG A CD  1 
ATOM   2191 N NE  . ARG A 1 305 ? -0.678  -16.345 30.287  1.00 64.54  ?  299 ARG A NE  1 
ATOM   2192 C CZ  . ARG A 1 305 ? -0.615  -17.651 30.088  1.00 67.55  ?  299 ARG A CZ  1 
ATOM   2193 N NH1 . ARG A 1 305 ? -1.401  -18.491 30.748  1.00 59.17  ?  299 ARG A NH1 1 
ATOM   2194 N NH2 . ARG A 1 305 ? 0.264   -18.128 29.206  1.00 71.65  ?  299 ARG A NH2 1 
ATOM   2195 N N   . ASP A 1 306 ? -6.170  -12.716 31.457  1.00 58.45  ?  300 ASP A N   1 
ATOM   2196 C CA  . ASP A 1 306 ? -7.549  -12.850 31.933  1.00 61.95  ?  300 ASP A CA  1 
ATOM   2197 C C   . ASP A 1 306 ? -8.519  -12.167 30.983  1.00 61.12  ?  300 ASP A C   1 
ATOM   2198 O O   . ASP A 1 306 ? -9.610  -12.678 30.712  1.00 66.06  ?  300 ASP A O   1 
ATOM   2199 C CB  . ASP A 1 306 ? -7.708  -12.276 33.340  1.00 63.71  ?  300 ASP A CB  1 
ATOM   2200 C CG  . ASP A 1 306 ? -7.193  -13.216 34.425  1.00 69.72  ?  300 ASP A CG  1 
ATOM   2201 O OD1 . ASP A 1 306 ? -6.628  -14.297 34.074  1.00 67.34  -1 300 ASP A OD1 1 
ATOM   2202 O OD2 . ASP A 1 306 ? -7.354  -12.861 35.628  1.00 64.54  ?  300 ASP A OD2 1 
ATOM   2203 N N   . GLU A 1 307 ? -8.124  -11.028 30.450  1.00 61.17  ?  301 GLU A N   1 
ATOM   2204 C CA  . GLU A 1 307 ? -8.962  -10.333 29.489  1.00 65.06  ?  301 GLU A CA  1 
ATOM   2205 C C   . GLU A 1 307 ? -9.199  -11.165 28.228  1.00 57.76  ?  301 GLU A C   1 
ATOM   2206 O O   . GLU A 1 307 ? -10.260 -11.060 27.616  1.00 59.11  ?  301 GLU A O   1 
ATOM   2207 C CB  . GLU A 1 307 ? -8.312  -8.983  29.177  1.00 62.09  ?  301 GLU A CB  1 
ATOM   2208 C CG  . GLU A 1 307 ? -9.041  -8.140  28.192  1.00 65.28  ?  301 GLU A CG  1 
ATOM   2209 C CD  . GLU A 1 307 ? -8.406  -8.251  26.824  1.00 79.33  ?  301 GLU A CD  1 
ATOM   2210 O OE1 . GLU A 1 307 ? -7.183  -7.929  26.733  1.00 82.41  ?  301 GLU A OE1 1 
ATOM   2211 O OE2 . GLU A 1 307 ? -9.119  -8.656  25.859  1.00 77.93  -1 301 GLU A OE2 1 
ATOM   2212 N N   . LEU A 1 308 ? -8.236  -12.003 27.834  1.00 60.92  ?  302 LEU A N   1 
ATOM   2213 C CA  . LEU A 1 308 ? -8.376  -12.790 26.610  1.00 57.36  ?  302 LEU A CA  1 
ATOM   2214 C C   . LEU A 1 308 ? -9.183  -14.051 26.870  1.00 58.90  ?  302 LEU A C   1 
ATOM   2215 O O   . LEU A 1 308 ? -9.945  -14.496 26.007  1.00 56.94  ?  302 LEU A O   1 
ATOM   2216 C CB  . LEU A 1 308 ? -7.003  -13.156 26.043  1.00 53.75  ?  302 LEU A CB  1 
ATOM   2217 C CG  . LEU A 1 308 ? -6.153  -12.070 25.344  1.00 59.53  ?  302 LEU A CG  1 
ATOM   2218 C CD1 . LEU A 1 308 ? -4.688  -12.507 25.244  1.00 50.27  ?  302 LEU A CD1 1 
ATOM   2219 C CD2 . LEU A 1 308 ? -6.708  -11.712 23.958  1.00 52.59  ?  302 LEU A CD2 1 
ATOM   2220 N N   . ILE A 1 309 ? -9.008  -14.643 28.049  1.00 54.90  ?  303 ILE A N   1 
ATOM   2221 C CA  . ILE A 1 309 ? -9.863  -15.736 28.451  1.00 55.22  ?  303 ILE A CA  1 
ATOM   2222 C C   . ILE A 1 309 ? -11.302 -15.272 28.485  1.00 61.18  ?  303 ILE A C   1 
ATOM   2223 O O   . ILE A 1 309 ? -12.207 -15.964 28.002  1.00 63.69  ?  303 ILE A O   1 
ATOM   2224 C CB  . ILE A 1 309 ? -9.404  -16.283 29.810  1.00 62.73  ?  303 ILE A CB  1 
ATOM   2225 C CG1 . ILE A 1 309 ? -8.038  -16.966 29.641  1.00 54.69  ?  303 ILE A CG1 1 
ATOM   2226 C CG2 . ILE A 1 309 ? -10.466 -17.226 30.393  1.00 54.57  ?  303 ILE A CG2 1 
ATOM   2227 C CD1 . ILE A 1 309 ? -7.433  -17.408 30.923  1.00 52.01  ?  303 ILE A CD1 1 
ATOM   2228 N N   . ARG A 1 310 ? -11.531 -14.076 29.026  1.00 62.24  ?  304 ARG A N   1 
ATOM   2229 C CA  . ARG A 1 310 ? -12.887 -13.549 29.140  1.00 59.18  ?  304 ARG A CA  1 
ATOM   2230 C C   . ARG A 1 310 ? -13.471 -13.233 27.775  1.00 57.89  ?  304 ARG A C   1 
ATOM   2231 O O   . ARG A 1 310 ? -14.668 -13.410 27.551  1.00 64.40  ?  304 ARG A O   1 
ATOM   2232 C CB  . ARG A 1 310 ? -12.883 -12.301 30.017  1.00 63.93  ?  304 ARG A CB  1 
ATOM   2233 C CG  . ARG A 1 310 ? -14.059 -12.174 30.948  1.00 72.93  ?  304 ARG A CG  1 
ATOM   2234 C CD  . ARG A 1 310 ? -13.990 -10.860 31.708  1.00 77.18  ?  304 ARG A CD  1 
ATOM   2235 N NE  . ARG A 1 310 ? -13.328 -11.065 32.996  1.00 81.61  ?  304 ARG A NE  1 
ATOM   2236 C CZ  . ARG A 1 310 ? -12.209 -10.451 33.376  1.00 86.80  ?  304 ARG A CZ  1 
ATOM   2237 N NH1 . ARG A 1 310 ? -11.631 -9.518  32.620  1.00 78.82  ?  304 ARG A NH1 1 
ATOM   2238 N NH2 . ARG A 1 310 ? -11.646 -10.787 34.538  1.00 85.69  ?  304 ARG A NH2 1 
ATOM   2239 N N   . ARG A 1 311 ? -12.653 -12.748 26.851  1.00 55.80  ?  305 ARG A N   1 
ATOM   2240 C CA  . ARG A 1 311 ? -13.212 -12.423 25.548  1.00 58.33  ?  305 ARG A CA  1 
ATOM   2241 C C   . ARG A 1 311 ? -13.501 -13.675 24.732  1.00 60.49  ?  305 ARG A C   1 
ATOM   2242 O O   . ARG A 1 311 ? -14.439 -13.682 23.933  1.00 61.51  ?  305 ARG A O   1 
ATOM   2243 C CB  . ARG A 1 311 ? -12.271 -11.503 24.772  1.00 52.58  ?  305 ARG A CB  1 
ATOM   2244 C CG  . ARG A 1 311 ? -12.759 -11.101 23.379  1.00 50.74  ?  305 ARG A CG  1 
ATOM   2245 C CD  . ARG A 1 311 ? -11.598 -10.688 22.461  1.00 60.48  ?  305 ARG A CD  1 
ATOM   2246 N NE  . ARG A 1 311 ? -10.671 -9.778  23.129  1.00 60.69  ?  305 ARG A NE  1 
ATOM   2247 C CZ  . ARG A 1 311 ? -9.424  -9.540  22.734  1.00 70.48  ?  305 ARG A CZ  1 
ATOM   2248 N NH1 . ARG A 1 311 ? -8.926  -10.087 21.632  1.00 65.66  ?  305 ARG A NH1 1 
ATOM   2249 N NH2 . ARG A 1 311 ? -8.655  -8.729  23.462  1.00 64.67  ?  305 ARG A NH2 1 
ATOM   2250 N N   . LEU A 1 312 ? -12.726 -14.734 24.921  1.00 57.65  ?  306 LEU A N   1 
ATOM   2251 C CA  . LEU A 1 312 ? -12.663 -15.794 23.936  1.00 54.96  ?  306 LEU A CA  1 
ATOM   2252 C C   . LEU A 1 312 ? -13.113 -17.141 24.440  1.00 54.24  ?  306 LEU A C   1 
ATOM   2253 O O   . LEU A 1 312 ? -13.628 -17.920 23.646  1.00 51.05  ?  306 LEU A O   1 
ATOM   2254 C CB  . LEU A 1 312 ? -11.240 -15.948 23.402  1.00 52.93  ?  306 LEU A CB  1 
ATOM   2255 C CG  . LEU A 1 312 ? -10.768 -14.772 22.559  1.00 58.55  ?  306 LEU A CG  1 
ATOM   2256 C CD1 . LEU A 1 312 ? -9.254  -14.713 22.540  1.00 48.99  ?  306 LEU A CD1 1 
ATOM   2257 C CD2 . LEU A 1 312 ? -11.335 -14.907 21.161  1.00 52.93  ?  306 LEU A CD2 1 
ATOM   2258 N N   . VAL A 1 313 ? -12.914 -17.452 25.711  1.00 56.76  ?  307 VAL A N   1 
ATOM   2259 C CA  . VAL A 1 313 ? -13.097 -18.830 26.138  1.00 58.05  ?  307 VAL A CA  1 
ATOM   2260 C C   . VAL A 1 313 ? -14.582 -19.091 26.335  1.00 68.61  ?  307 VAL A C   1 
ATOM   2261 O O   . VAL A 1 313 ? -15.161 -19.931 25.615  1.00 62.44  ?  307 VAL A O   1 
ATOM   2262 C CB  . VAL A 1 313 ? -12.313 -19.147 27.393  1.00 56.04  ?  307 VAL A CB  1 
ATOM   2263 C CG1 . VAL A 1 313 ? -12.852 -20.387 28.018  1.00 52.41  ?  307 VAL A CG1 1 
ATOM   2264 C CG2 . VAL A 1 313 ? -10.825 -19.321 27.058  1.00 55.38  ?  307 VAL A CG2 1 
ATOM   2265 O OXT . VAL A 1 313 ? -15.216 -18.439 27.185  1.00 69.71  -1 307 VAL A OXT 1 
ATOM   2266 N N   . THR B 1 12  ? 27.052  -22.872 52.652  1.00 92.80  ?  6   THR B N   1 
ATOM   2267 C CA  . THR B 1 12  ? 26.978  -24.240 52.151  1.00 90.17  ?  6   THR B CA  1 
ATOM   2268 C C   . THR B 1 12  ? 25.608  -24.534 51.527  1.00 91.07  ?  6   THR B C   1 
ATOM   2269 O O   . THR B 1 12  ? 24.571  -24.076 52.030  1.00 80.06  ?  6   THR B O   1 
ATOM   2270 C CB  . THR B 1 12  ? 27.258  -25.271 53.277  1.00 94.88  ?  6   THR B CB  1 
ATOM   2271 O OG1 . THR B 1 12  ? 28.505  -24.961 53.917  1.00 97.27  ?  6   THR B OG1 1 
ATOM   2272 C CG2 . THR B 1 12  ? 27.285  -26.725 52.727  1.00 79.85  ?  6   THR B CG2 1 
ATOM   2273 N N   . GLU B 1 13  ? 25.621  -25.297 50.429  1.00 92.48  ?  7   GLU B N   1 
ATOM   2274 C CA  . GLU B 1 13  ? 24.411  -25.800 49.794  1.00 84.98  ?  7   GLU B CA  1 
ATOM   2275 C C   . GLU B 1 13  ? 23.830  -26.968 50.589  1.00 79.65  ?  7   GLU B C   1 
ATOM   2276 O O   . GLU B 1 13  ? 24.521  -27.624 51.377  1.00 75.21  ?  7   GLU B O   1 
ATOM   2277 C CB  . GLU B 1 13  ? 24.703  -26.249 48.360  1.00 77.48  ?  7   GLU B CB  1 
ATOM   2278 C CG  . GLU B 1 13  ? 24.518  -25.161 47.317  1.00 89.60  ?  7   GLU B CG  1 
ATOM   2279 C CD  . GLU B 1 13  ? 23.051  -24.725 47.143  1.00 92.94  ?  7   GLU B CD  1 
ATOM   2280 O OE1 . GLU B 1 13  ? 22.620  -24.545 45.969  1.00 83.21  ?  7   GLU B OE1 1 
ATOM   2281 O OE2 . GLU B 1 13  ? 22.336  -24.563 48.177  1.00 88.85  -1 7   GLU B OE2 1 
ATOM   2282 N N   . ARG B 1 14  ? 22.526  -27.228 50.369  1.00 75.02  ?  8   ARG B N   1 
ATOM   2283 C CA  . ARG B 1 14  ? 21.967  -28.449 50.931  1.00 70.93  ?  8   ARG B CA  1 
ATOM   2284 C C   . ARG B 1 14  ? 22.406  -29.656 50.092  1.00 67.15  ?  8   ARG B C   1 
ATOM   2285 O O   . ARG B 1 14  ? 22.702  -29.518 48.904  1.00 67.43  ?  8   ARG B O   1 
ATOM   2286 C CB  . ARG B 1 14  ? 20.447  -28.362 50.982  1.00 58.12  ?  8   ARG B CB  1 
ATOM   2287 C CG  . ARG B 1 14  ? 19.788  -28.173 49.626  1.00 70.11  ?  8   ARG B CG  1 
ATOM   2288 C CD  . ARG B 1 14  ? 18.283  -28.444 49.676  1.00 68.45  ?  8   ARG B CD  1 
ATOM   2289 N NE  . ARG B 1 14  ? 17.627  -28.353 48.372  1.00 70.15  ?  8   ARG B NE  1 
ATOM   2290 C CZ  . ARG B 1 14  ? 17.370  -29.387 47.576  1.00 68.59  ?  8   ARG B CZ  1 
ATOM   2291 N NH1 . ARG B 1 14  ? 17.769  -30.612 47.882  1.00 68.05  ?  8   ARG B NH1 1 
ATOM   2292 N NH2 . ARG B 1 14  ? 16.701  -29.188 46.438  1.00 65.20  ?  8   ARG B NH2 1 
ATOM   2293 N N   . PRO B 1 15  ? 22.477  -30.844 50.688  1.00 60.94  ?  9   PRO B N   1 
ATOM   2294 C CA  . PRO B 1 15  ? 22.839  -32.041 49.908  1.00 69.26  ?  9   PRO B CA  1 
ATOM   2295 C C   . PRO B 1 15  ? 21.796  -32.367 48.845  1.00 64.29  ?  9   PRO B C   1 
ATOM   2296 O O   . PRO B 1 15  ? 20.610  -32.097 49.009  1.00 62.42  ?  9   PRO B O   1 
ATOM   2297 C CB  . PRO B 1 15  ? 22.898  -33.162 50.958  1.00 66.73  ?  9   PRO B CB  1 
ATOM   2298 C CG  . PRO B 1 15  ? 22.746  -32.498 52.281  1.00 69.40  ?  9   PRO B CG  1 
ATOM   2299 C CD  . PRO B 1 15  ? 22.109  -31.167 52.072  1.00 64.71  ?  9   PRO B CD  1 
ATOM   2300 N N   . ILE B 1 16  ? 22.254  -32.959 47.742  1.00 59.30  ?  10  ILE B N   1 
ATOM   2301 C CA  . ILE B 1 16  ? 21.337  -33.487 46.745  1.00 60.81  ?  10  ILE B CA  1 
ATOM   2302 C C   . ILE B 1 16  ? 20.719  -34.773 47.277  1.00 61.13  ?  10  ILE B C   1 
ATOM   2303 O O   . ILE B 1 16  ? 21.424  -35.714 47.667  1.00 62.87  ?  10  ILE B O   1 
ATOM   2304 C CB  . ILE B 1 16  ? 22.063  -33.736 45.414  1.00 59.37  ?  10  ILE B CB  1 
ATOM   2305 C CG1 . ILE B 1 16  ? 22.775  -32.478 44.941  1.00 59.77  ?  10  ILE B CG1 1 
ATOM   2306 C CG2 . ILE B 1 16  ? 21.092  -34.257 44.349  1.00 53.07  ?  10  ILE B CG2 1 
ATOM   2307 C CD1 . ILE B 1 16  ? 23.894  -32.771 43.996  1.00 58.57  ?  10  ILE B CD1 1 
ATOM   2308 N N   . ARG B 1 17  ? 19.401  -34.838 47.287  1.00 57.05  ?  11  ARG B N   1 
ATOM   2309 C CA  . ARG B 1 17  ? 18.734  -36.027 47.790  1.00 62.82  ?  11  ARG B CA  1 
ATOM   2310 C C   . ARG B 1 17  ? 18.540  -37.002 46.637  1.00 61.72  ?  11  ARG B C   1 
ATOM   2311 O O   . ARG B 1 17  ? 17.858  -36.682 45.651  1.00 58.66  ?  11  ARG B O   1 
ATOM   2312 C CB  . ARG B 1 17  ? 17.422  -35.653 48.467  1.00 63.53  ?  11  ARG B CB  1 
ATOM   2313 C CG  . ARG B 1 17  ? 17.651  -34.708 49.636  1.00 59.30  ?  11  ARG B CG  1 
ATOM   2314 C CD  . ARG B 1 17  ? 16.485  -34.779 50.573  1.00 65.24  ?  11  ARG B CD  1 
ATOM   2315 N NE  . ARG B 1 17  ? 16.609  -35.862 51.539  1.00 66.46  ?  11  ARG B NE  1 
ATOM   2316 C CZ  . ARG B 1 17  ? 15.672  -36.775 51.758  1.00 65.13  ?  11  ARG B CZ  1 
ATOM   2317 N NH1 . ARG B 1 17  ? 14.557  -36.813 51.044  1.00 67.27  ?  11  ARG B NH1 1 
ATOM   2318 N NH2 . ARG B 1 17  ? 15.852  -37.667 52.724  1.00 65.59  ?  11  ARG B NH2 1 
ATOM   2319 N N   . VAL B 1 18  ? 19.190  -38.169 46.742  1.00 55.89  ?  12  VAL B N   1 
ATOM   2320 C CA  . VAL B 1 18  ? 19.185  -39.180 45.692  1.00 57.27  ?  12  VAL B CA  1 
ATOM   2321 C C   . VAL B 1 18  ? 18.404  -40.401 46.160  1.00 56.32  ?  12  VAL B C   1 
ATOM   2322 O O   . VAL B 1 18  ? 18.472  -40.803 47.328  1.00 57.27  ?  12  VAL B O   1 
ATOM   2323 C CB  . VAL B 1 18  ? 20.618  -39.566 45.267  1.00 58.90  ?  12  VAL B CB  1 
ATOM   2324 C CG1 . VAL B 1 18  ? 20.586  -40.671 44.205  1.00 59.20  ?  12  VAL B CG1 1 
ATOM   2325 C CG2 . VAL B 1 18  ? 21.362  -38.342 44.742  1.00 54.77  ?  12  VAL B CG2 1 
ATOM   2326 N N   . ALA B 1 19  ? 17.651  -40.981 45.244  1.00 59.12  ?  13  ALA B N   1 
ATOM   2327 C CA  . ALA B 1 19  ? 16.932  -42.221 45.477  1.00 58.09  ?  13  ALA B CA  1 
ATOM   2328 C C   . ALA B 1 19  ? 17.461  -43.281 44.520  1.00 56.09  ?  13  ALA B C   1 
ATOM   2329 O O   . ALA B 1 19  ? 17.718  -43.006 43.346  1.00 57.08  ?  13  ALA B O   1 
ATOM   2330 C CB  . ALA B 1 19  ? 15.427  -42.014 45.286  1.00 52.42  ?  13  ALA B CB  1 
ATOM   2331 N N   . ILE B 1 20  ? 17.633  -44.492 45.011  1.00 55.80  ?  14  ILE B N   1 
ATOM   2332 C CA  . ILE B 1 20  ? 18.076  -45.596 44.171  1.00 60.92  ?  14  ILE B CA  1 
ATOM   2333 C C   . ILE B 1 20  ? 16.850  -46.416 43.760  1.00 58.39  ?  14  ILE B C   1 
ATOM   2334 O O   . ILE B 1 20  ? 16.098  -46.901 44.612  1.00 54.98  ?  14  ILE B O   1 
ATOM   2335 C CB  . ILE B 1 20  ? 19.147  -46.434 44.891  1.00 57.27  ?  14  ILE B CB  1 
ATOM   2336 C CG1 . ILE B 1 20  ? 20.387  -45.562 45.079  1.00 58.21  ?  14  ILE B CG1 1 
ATOM   2337 C CG2 . ILE B 1 20  ? 19.514  -47.664 44.100  1.00 55.15  ?  14  ILE B CG2 1 
ATOM   2338 C CD1 . ILE B 1 20  ? 21.284  -45.989 46.186  1.00 58.26  ?  14  ILE B CD1 1 
ATOM   2339 N N   . ILE B 1 21  ? 16.631  -46.526 42.451  1.00 56.15  ?  15  ILE B N   1 
ATOM   2340 C CA  . ILE B 1 21  ? 15.502  -47.256 41.889  1.00 58.22  ?  15  ILE B CA  1 
ATOM   2341 C C   . ILE B 1 21  ? 16.012  -48.608 41.436  1.00 60.25  ?  15  ILE B C   1 
ATOM   2342 O O   . ILE B 1 21  ? 16.680  -48.708 40.402  1.00 58.84  ?  15  ILE B O   1 
ATOM   2343 C CB  . ILE B 1 21  ? 14.851  -46.522 40.708  1.00 57.89  ?  15  ILE B CB  1 
ATOM   2344 C CG1 . ILE B 1 21  ? 14.679  -45.012 40.962  1.00 62.36  ?  15  ILE B CG1 1 
ATOM   2345 C CG2 . ILE B 1 21  ? 13.534  -47.171 40.376  1.00 48.40  ?  15  ILE B CG2 1 
ATOM   2346 C CD1 . ILE B 1 21  ? 13.974  -44.632 42.251  1.00 58.51  ?  15  ILE B CD1 1 
ATOM   2347 N N   . GLY B 1 22  ? 15.658  -49.656 42.179  1.00 63.62  ?  16  GLY B N   1 
ATOM   2348 C CA  . GLY B 1 22  ? 16.014  -51.005 41.802  1.00 59.69  ?  16  GLY B CA  1 
ATOM   2349 C C   . GLY B 1 22  ? 17.271  -51.407 42.525  1.00 63.77  ?  16  GLY B C   1 
ATOM   2350 O O   . GLY B 1 22  ? 18.348  -50.886 42.225  1.00 64.71  ?  16  GLY B O   1 
ATOM   2351 N N   . TYR B 1 23  ? 17.149  -52.308 43.495  1.00 66.22  ?  17  TYR B N   1 
ATOM   2352 C CA  . TYR B 1 23  ? 18.271  -52.692 44.343  1.00 65.47  ?  17  TYR B CA  1 
ATOM   2353 C C   . TYR B 1 23  ? 18.759  -54.066 43.904  1.00 68.65  ?  17  TYR B C   1 
ATOM   2354 O O   . TYR B 1 23  ? 18.475  -55.087 44.535  1.00 71.38  ?  17  TYR B O   1 
ATOM   2355 C CB  . TYR B 1 23  ? 17.883  -52.698 45.788  1.00 63.86  ?  17  TYR B CB  1 
ATOM   2356 C CG  . TYR B 1 23  ? 19.081  -52.719 46.692  1.00 65.50  ?  17  TYR B CG  1 
ATOM   2357 C CD1 . TYR B 1 23  ? 19.920  -51.620 46.778  1.00 62.36  ?  17  TYR B CD1 1 
ATOM   2358 C CD2 . TYR B 1 23  ? 19.392  -53.842 47.442  1.00 66.91  ?  17  TYR B CD2 1 
ATOM   2359 C CE1 . TYR B 1 23  ? 21.019  -51.629 47.598  1.00 62.65  ?  17  TYR B CE1 1 
ATOM   2360 C CE2 . TYR B 1 23  ? 20.493  -53.860 48.273  1.00 66.97  ?  17  TYR B CE2 1 
ATOM   2361 C CZ  . TYR B 1 23  ? 21.298  -52.746 48.350  1.00 67.42  ?  17  TYR B CZ  1 
ATOM   2362 O OH  . TYR B 1 23  ? 22.406  -52.747 49.169  1.00 75.86  ?  17  TYR B OH  1 
ATOM   2363 N N   . GLY B 1 24  ? 19.498  -54.086 42.802  1.00 66.84  ?  18  GLY B N   1 
ATOM   2364 C CA  . GLY B 1 24  ? 20.180  -55.298 42.394  1.00 58.20  ?  18  GLY B CA  1 
ATOM   2365 C C   . GLY B 1 24  ? 21.682  -55.132 42.456  1.00 60.89  ?  18  GLY B C   1 
ATOM   2366 O O   . GLY B 1 24  ? 22.235  -54.518 43.370  1.00 61.28  ?  18  GLY B O   1 
ATOM   2367 N N   . ASN B 1 25  ? 22.348  -55.671 41.445  1.00 62.65  ?  19  ASN B N   1 
ATOM   2368 C CA  . ASN B 1 25  ? 23.798  -55.584 41.341  1.00 62.55  ?  19  ASN B CA  1 
ATOM   2369 C C   . ASN B 1 25  ? 24.277  -54.132 41.291  1.00 64.78  ?  19  ASN B C   1 
ATOM   2370 O O   . ASN B 1 25  ? 25.091  -53.696 42.121  1.00 64.17  ?  19  ASN B O   1 
ATOM   2371 C CB  . ASN B 1 25  ? 24.232  -56.343 40.092  1.00 60.58  ?  19  ASN B CB  1 
ATOM   2372 C CG  . ASN B 1 25  ? 25.693  -56.294 39.878  1.00 66.48  ?  19  ASN B CG  1 
ATOM   2373 O OD1 . ASN B 1 25  ? 26.135  -56.215 38.730  1.00 69.27  ?  19  ASN B OD1 1 
ATOM   2374 N ND2 . ASN B 1 25  ? 26.476  -56.369 40.961  1.00 69.88  ?  19  ASN B ND2 1 
ATOM   2375 N N   . ILE B 1 26  ? 23.816  -53.378 40.285  1.00 63.82  ?  20  ILE B N   1 
ATOM   2376 C CA  . ILE B 1 26  ? 24.180  -51.968 40.186  1.00 62.25  ?  20  ILE B CA  1 
ATOM   2377 C C   . ILE B 1 26  ? 23.676  -51.209 41.404  1.00 61.32  ?  20  ILE B C   1 
ATOM   2378 O O   . ILE B 1 26  ? 24.381  -50.336 41.945  1.00 60.37  ?  20  ILE B O   1 
ATOM   2379 C CB  . ILE B 1 26  ? 23.647  -51.351 38.877  1.00 62.62  ?  20  ILE B CB  1 
ATOM   2380 C CG1 . ILE B 1 26  ? 24.247  -52.046 37.660  1.00 59.41  ?  20  ILE B CG1 1 
ATOM   2381 C CG2 . ILE B 1 26  ? 24.010  -49.870 38.803  1.00 55.09  ?  20  ILE B CG2 1 
ATOM   2382 C CD1 . ILE B 1 26  ? 25.642  -51.602 37.390  1.00 60.74  ?  20  ILE B CD1 1 
ATOM   2383 N N   . GLY B 1 27  ? 22.460  -51.543 41.866  1.00 60.53  ?  21  GLY B N   1 
ATOM   2384 C CA  . GLY B 1 27  ? 21.860  -50.806 42.973  1.00 60.74  ?  21  GLY B CA  1 
ATOM   2385 C C   . GLY B 1 27  ? 22.697  -50.859 44.240  1.00 61.51  ?  21  GLY B C   1 
ATOM   2386 O O   . GLY B 1 27  ? 22.819  -49.863 44.961  1.00 56.94  ?  21  GLY B O   1 
ATOM   2387 N N   . GLN B 1 28  ? 23.313  -52.018 44.509  1.00 65.20  ?  22  GLN B N   1 
ATOM   2388 C CA  . GLN B 1 28  ? 24.120  -52.170 45.718  1.00 63.75  ?  22  GLN B CA  1 
ATOM   2389 C C   . GLN B 1 28  ? 25.351  -51.289 45.662  1.00 59.08  ?  22  GLN B C   1 
ATOM   2390 O O   . GLN B 1 28  ? 25.728  -50.674 46.669  1.00 59.74  ?  22  GLN B O   1 
ATOM   2391 C CB  . GLN B 1 28  ? 24.517  -53.633 45.912  1.00 61.17  ?  22  GLN B CB  1 
ATOM   2392 C CG  . GLN B 1 28  ? 23.324  -54.507 46.287  1.00 67.89  ?  22  GLN B CG  1 
ATOM   2393 C CD  . GLN B 1 28  ? 23.578  -55.981 46.072  1.00 70.40  ?  22  GLN B CD  1 
ATOM   2394 O OE1 . GLN B 1 28  ? 24.597  -56.505 46.506  1.00 74.73  ?  22  GLN B OE1 1 
ATOM   2395 N NE2 . GLN B 1 28  ? 22.652  -56.655 45.392  1.00 69.22  ?  22  GLN B NE2 1 
ATOM   2396 N N   . TYR B 1 29  ? 25.977  -51.195 44.490  1.00 55.10  ?  23  TYR B N   1 
ATOM   2397 C CA  . TYR B 1 29  ? 27.156  -50.344 44.390  1.00 60.31  ?  23  TYR B CA  1 
ATOM   2398 C C   . TYR B 1 29  ? 26.767  -48.874 44.432  1.00 58.79  ?  23  TYR B C   1 
ATOM   2399 O O   . TYR B 1 29  ? 27.462  -48.071 45.068  1.00 57.91  ?  23  TYR B O   1 
ATOM   2400 C CB  . TYR B 1 29  ? 27.952  -50.668 43.119  1.00 62.40  ?  23  TYR B CB  1 
ATOM   2401 C CG  . TYR B 1 29  ? 28.788  -51.936 43.185  1.00 58.39  ?  23  TYR B CG  1 
ATOM   2402 C CD1 . TYR B 1 29  ? 30.032  -51.943 43.803  1.00 55.58  ?  23  TYR B CD1 1 
ATOM   2403 C CD2 . TYR B 1 29  ? 28.330  -53.129 42.612  1.00 62.18  ?  23  TYR B CD2 1 
ATOM   2404 C CE1 . TYR B 1 29  ? 30.810  -53.102 43.855  1.00 53.94  ?  23  TYR B CE1 1 
ATOM   2405 C CE2 . TYR B 1 29  ? 29.097  -54.292 42.662  1.00 56.69  ?  23  TYR B CE2 1 
ATOM   2406 C CZ  . TYR B 1 29  ? 30.330  -54.267 43.285  1.00 55.57  ?  23  TYR B CZ  1 
ATOM   2407 O OH  . TYR B 1 29  ? 31.079  -55.409 43.339  1.00 57.10  ?  23  TYR B OH  1 
ATOM   2408 N N   . ALA B 1 30  ? 25.651  -48.508 43.770  1.00 55.86  ?  24  ALA B N   1 
ATOM   2409 C CA  . ALA B 1 30  ? 25.183  -47.121 43.802  1.00 57.16  ?  24  ALA B CA  1 
ATOM   2410 C C   . ALA B 1 30  ? 25.013  -46.619 45.230  1.00 57.74  ?  24  ALA B C   1 
ATOM   2411 O O   . ALA B 1 30  ? 25.393  -45.487 45.546  1.00 58.98  ?  24  ALA B O   1 
ATOM   2412 C CB  . ALA B 1 30  ? 23.866  -46.965 43.034  1.00 51.52  ?  24  ALA B CB  1 
ATOM   2413 N N   . LEU B 1 31  ? 24.441  -47.443 46.108  1.00 57.92  ?  25  LEU B N   1 
ATOM   2414 C CA  . LEU B 1 31  ? 24.319  -47.060 47.511  1.00 57.58  ?  25  LEU B CA  1 
ATOM   2415 C C   . LEU B 1 31  ? 25.656  -46.604 48.092  1.00 62.53  ?  25  LEU B C   1 
ATOM   2416 O O   . LEU B 1 31  ? 25.735  -45.559 48.750  1.00 66.58  ?  25  LEU B O   1 
ATOM   2417 C CB  . LEU B 1 31  ? 23.748  -48.224 48.311  1.00 60.33  ?  25  LEU B CB  1 
ATOM   2418 C CG  . LEU B 1 31  ? 23.099  -47.881 49.645  1.00 68.41  ?  25  LEU B CG  1 
ATOM   2419 C CD1 . LEU B 1 31  ? 21.945  -48.828 49.904  1.00 71.52  ?  25  LEU B CD1 1 
ATOM   2420 C CD2 . LEU B 1 31  ? 24.135  -48.005 50.741  1.00 69.98  ?  25  LEU B CD2 1 
ATOM   2421 N N   . GLN B 1 32  ? 26.727  -47.363 47.844  1.00 57.78  ?  26  GLN B N   1 
ATOM   2422 C CA  . GLN B 1 32  ? 28.031  -46.969 48.372  1.00 61.85  ?  26  GLN B CA  1 
ATOM   2423 C C   . GLN B 1 32  ? 28.509  -45.686 47.725  1.00 58.39  ?  26  GLN B C   1 
ATOM   2424 O O   . GLN B 1 32  ? 29.090  -44.831 48.396  1.00 62.11  ?  26  GLN B O   1 
ATOM   2425 C CB  . GLN B 1 32  ? 29.061  -48.084 48.166  1.00 58.08  ?  26  GLN B CB  1 
ATOM   2426 C CG  . GLN B 1 32  ? 28.443  -49.450 48.292  1.00 60.19  ?  26  GLN B CG  1 
ATOM   2427 C CD  . GLN B 1 32  ? 29.451  -50.559 48.373  1.00 61.21  ?  26  GLN B CD  1 
ATOM   2428 O OE1 . GLN B 1 32  ? 30.397  -50.631 47.584  1.00 59.11  ?  26  GLN B OE1 1 
ATOM   2429 N NE2 . GLN B 1 32  ? 29.249  -51.448 49.331  1.00 62.24  ?  26  GLN B NE2 1 
ATOM   2430 N N   . ALA B 1 33  ? 28.266  -45.529 46.424  1.00 57.06  ?  27  ALA B N   1 
ATOM   2431 C CA  . ALA B 1 33  ? 28.678  -44.305 45.752  1.00 58.06  ?  27  ALA B CA  1 
ATOM   2432 C C   . ALA B 1 33  ? 27.996  -43.083 46.367  1.00 59.91  ?  27  ALA B C   1 
ATOM   2433 O O   . ALA B 1 33  ? 28.661  -42.097 46.709  1.00 59.44  ?  27  ALA B O   1 
ATOM   2434 C CB  . ALA B 1 33  ? 28.388  -44.409 44.257  1.00 54.38  ?  27  ALA B CB  1 
ATOM   2435 N N   . VAL B 1 34  ? 26.666  -43.143 46.527  1.00 61.13  ?  28  VAL B N   1 
ATOM   2436 C CA  . VAL B 1 34  ? 25.905  -42.038 47.119  1.00 60.43  ?  28  VAL B CA  1 
ATOM   2437 C C   . VAL B 1 34  ? 26.439  -41.706 48.506  1.00 62.34  ?  28  VAL B C   1 
ATOM   2438 O O   . VAL B 1 34  ? 26.674  -40.535 48.838  1.00 62.19  ?  28  VAL B O   1 
ATOM   2439 C CB  . VAL B 1 34  ? 24.405  -42.385 47.175  1.00 59.03  ?  28  VAL B CB  1 
ATOM   2440 C CG1 . VAL B 1 34  ? 23.689  -41.490 48.182  1.00 56.40  ?  28  VAL B CG1 1 
ATOM   2441 C CG2 . VAL B 1 34  ? 23.756  -42.280 45.787  1.00 55.73  ?  28  VAL B CG2 1 
ATOM   2442 N N   . GLU B 1 35  ? 26.651  -42.737 49.333  1.00 61.03  ?  29  GLU B N   1 
ATOM   2443 C CA  . GLU B 1 35  ? 27.187  -42.519 50.675  1.00 63.84  ?  29  GLU B CA  1 
ATOM   2444 C C   . GLU B 1 35  ? 28.504  -41.756 50.635  1.00 63.05  ?  29  GLU B C   1 
ATOM   2445 O O   . GLU B 1 35  ? 28.714  -40.817 51.410  1.00 65.58  ?  29  GLU B O   1 
ATOM   2446 C CB  . GLU B 1 35  ? 27.380  -43.851 51.397  1.00 65.22  ?  29  GLU B CB  1 
ATOM   2447 C CG  . GLU B 1 35  ? 27.219  -43.760 52.906  1.00 79.71  ?  29  GLU B CG  1 
ATOM   2448 C CD  . GLU B 1 35  ? 25.805  -44.124 53.379  1.00 93.58  ?  29  GLU B CD  1 
ATOM   2449 O OE1 . GLU B 1 35  ? 25.240  -45.136 52.877  1.00 88.42  ?  29  GLU B OE1 1 
ATOM   2450 O OE2 . GLU B 1 35  ? 25.266  -43.400 54.256  1.00 98.51  -1 29  GLU B OE2 1 
ATOM   2451 N N   . GLU B 1 36  ? 29.417  -42.160 49.748  1.00 63.25  ?  30  GLU B N   1 
ATOM   2452 C CA  . GLU B 1 36  ? 30.721  -41.510 49.691  1.00 62.61  ?  30  GLU B CA  1 
ATOM   2453 C C   . GLU B 1 36  ? 30.627  -40.102 49.129  1.00 61.62  ?  30  GLU B C   1 
ATOM   2454 O O   . GLU B 1 36  ? 31.428  -39.236 49.503  1.00 67.12  ?  30  GLU B O   1 
ATOM   2455 C CB  . GLU B 1 36  ? 31.682  -42.327 48.833  1.00 65.72  ?  30  GLU B CB  1 
ATOM   2456 C CG  . GLU B 1 36  ? 32.356  -43.441 49.546  1.00 68.81  ?  30  GLU B CG  1 
ATOM   2457 C CD  . GLU B 1 36  ? 32.728  -43.089 50.962  1.00 72.92  ?  30  GLU B CD  1 
ATOM   2458 O OE1 . GLU B 1 36  ? 33.605  -42.199 51.173  1.00 70.03  ?  30  GLU B OE1 1 
ATOM   2459 O OE2 . GLU B 1 36  ? 32.132  -43.726 51.857  1.00 70.50  -1 30  GLU B OE2 1 
ATOM   2460 N N   . ALA B 1 37  ? 29.690  -39.866 48.211  1.00 60.91  ?  31  ALA B N   1 
ATOM   2461 C CA  . ALA B 1 37  ? 29.566  -38.569 47.561  1.00 64.19  ?  31  ALA B CA  1 
ATOM   2462 C C   . ALA B 1 37  ? 29.333  -37.488 48.610  1.00 61.91  ?  31  ALA B C   1 
ATOM   2463 O O   . ALA B 1 37  ? 28.312  -37.526 49.317  1.00 64.85  ?  31  ALA B O   1 
ATOM   2464 C CB  . ALA B 1 37  ? 28.437  -38.578 46.536  1.00 61.72  ?  31  ALA B CB  1 
ATOM   2465 N N   . PRO B 1 38  ? 30.247  -36.528 48.752  1.00 61.30  ?  32  PRO B N   1 
ATOM   2466 C CA  . PRO B 1 38  ? 30.121  -35.543 49.835  1.00 63.22  ?  32  PRO B CA  1 
ATOM   2467 C C   . PRO B 1 38  ? 28.960  -34.606 49.661  1.00 62.46  ?  32  PRO B C   1 
ATOM   2468 O O   . PRO B 1 38  ? 28.548  -33.992 50.646  1.00 67.87  ?  32  PRO B O   1 
ATOM   2469 C CB  . PRO B 1 38  ? 31.446  -34.774 49.772  1.00 62.40  ?  32  PRO B CB  1 
ATOM   2470 C CG  . PRO B 1 38  ? 31.890  -34.910 48.334  1.00 63.97  ?  32  PRO B CG  1 
ATOM   2471 C CD  . PRO B 1 38  ? 31.406  -36.266 47.877  1.00 62.78  ?  32  PRO B CD  1 
ATOM   2472 N N   . ASP B 1 39  ? 28.424  -34.472 48.449  1.00 56.99  ?  33  ASP B N   1 
ATOM   2473 C CA  . ASP B 1 39  ? 27.385  -33.506 48.160  1.00 55.59  ?  33  ASP B CA  1 
ATOM   2474 C C   . ASP B 1 39  ? 26.021  -34.150 48.015  1.00 59.08  ?  33  ASP B C   1 
ATOM   2475 O O   . ASP B 1 39  ? 25.098  -33.521 47.494  1.00 60.62  ?  33  ASP B O   1 
ATOM   2476 C CB  . ASP B 1 39  ? 27.734  -32.707 46.902  1.00 61.64  ?  33  ASP B CB  1 
ATOM   2477 C CG  . ASP B 1 39  ? 28.069  -33.594 45.688  1.00 68.68  ?  33  ASP B CG  1 
ATOM   2478 O OD1 . ASP B 1 39  ? 28.419  -34.794 45.863  1.00 66.80  ?  33  ASP B OD1 1 
ATOM   2479 O OD2 . ASP B 1 39  ? 27.984  -33.070 44.545  1.00 67.35  -1 33  ASP B OD2 1 
ATOM   2480 N N   . MET B 1 40  ? 25.862  -35.382 48.474  1.00 61.02  ?  34  MET B N   1 
ATOM   2481 C CA  . MET B 1 40  ? 24.667  -36.141 48.147  1.00 61.75  ?  34  MET B CA  1 
ATOM   2482 C C   . MET B 1 40  ? 24.267  -36.946 49.364  1.00 58.31  ?  34  MET B C   1 
ATOM   2483 O O   . MET B 1 40  ? 25.082  -37.242 50.238  1.00 61.70  ?  34  MET B O   1 
ATOM   2484 C CB  . MET B 1 40  ? 24.904  -37.090 46.968  1.00 61.20  ?  34  MET B CB  1 
ATOM   2485 C CG  . MET B 1 40  ? 25.278  -36.336 45.707  1.00 68.11  ?  34  MET B CG  1 
ATOM   2486 S SD  . MET B 1 40  ? 25.367  -37.362 44.252  1.00 63.36  ?  34  MET B SD  1 
ATOM   2487 C CE  . MET B 1 40  ? 25.184  -38.918 45.082  1.00 59.42  ?  34  MET B CE  1 
ATOM   2488 N N   . GLU B 1 41  ? 23.003  -37.334 49.383  1.00 63.53  ?  35  GLU B N   1 
ATOM   2489 C CA  . GLU B 1 41  ? 22.364  -37.882 50.564  1.00 63.75  ?  35  GLU B CA  1 
ATOM   2490 C C   . GLU B 1 41  ? 21.365  -38.912 50.086  1.00 60.55  ?  35  GLU B C   1 
ATOM   2491 O O   . GLU B 1 41  ? 20.707  -38.700 49.066  1.00 62.76  ?  35  GLU B O   1 
ATOM   2492 C CB  . GLU B 1 41  ? 21.676  -36.766 51.340  1.00 70.59  ?  35  GLU B CB  1 
ATOM   2493 C CG  . GLU B 1 41  ? 21.169  -37.115 52.694  1.00 75.16  ?  35  GLU B CG  1 
ATOM   2494 C CD  . GLU B 1 41  ? 20.673  -35.874 53.391  1.00 75.81  ?  35  GLU B CD  1 
ATOM   2495 O OE1 . GLU B 1 41  ? 21.523  -35.157 53.967  1.00 84.32  ?  35  GLU B OE1 1 
ATOM   2496 O OE2 . GLU B 1 41  ? 19.454  -35.600 53.326  1.00 73.36  -1 35  GLU B OE2 1 
ATOM   2497 N N   . LEU B 1 42  ? 21.272  -40.032 50.784  1.00 60.78  ?  36  LEU B N   1 
ATOM   2498 C CA  . LEU B 1 42  ? 20.394  -41.103 50.340  1.00 60.54  ?  36  LEU B CA  1 
ATOM   2499 C C   . LEU B 1 42  ? 18.980  -40.842 50.849  1.00 63.82  ?  36  LEU B C   1 
ATOM   2500 O O   . LEU B 1 42  ? 18.744  -40.774 52.060  1.00 65.48  ?  36  LEU B O   1 
ATOM   2501 C CB  . LEU B 1 42  ? 20.899  -42.462 50.814  1.00 59.11  ?  36  LEU B CB  1 
ATOM   2502 C CG  . LEU B 1 42  ? 20.052  -43.621 50.292  1.00 59.95  ?  36  LEU B CG  1 
ATOM   2503 C CD1 . LEU B 1 42  ? 20.352  -43.881 48.836  1.00 57.78  ?  36  LEU B CD1 1 
ATOM   2504 C CD2 . LEU B 1 42  ? 20.295  -44.858 51.133  1.00 61.35  ?  36  LEU B CD2 1 
ATOM   2505 N N   . ALA B 1 43  ? 18.040  -40.680 49.927  1.00 63.55  ?  37  ALA B N   1 
ATOM   2506 C CA  . ALA B 1 43  ? 16.660  -40.533 50.351  1.00 60.37  ?  37  ALA B CA  1 
ATOM   2507 C C   . ALA B 1 43  ? 16.028  -41.890 50.650  1.00 64.88  ?  37  ALA B C   1 
ATOM   2508 O O   . ALA B 1 43  ? 15.170  -41.989 51.536  1.00 61.59  ?  37  ALA B O   1 
ATOM   2509 C CB  . ALA B 1 43  ? 15.885  -39.777 49.280  1.00 60.86  ?  37  ALA B CB  1 
ATOM   2510 N N   . GLY B 1 44  ? 16.461  -42.936 49.961  1.00 62.09  ?  38  GLY B N   1 
ATOM   2511 C CA  . GLY B 1 44  ? 15.891  -44.255 50.149  1.00 61.36  ?  38  GLY B CA  1 
ATOM   2512 C C   . GLY B 1 44  ? 16.137  -45.124 48.933  1.00 63.39  ?  38  GLY B C   1 
ATOM   2513 O O   . GLY B 1 44  ? 16.784  -44.717 47.965  1.00 63.85  ?  38  GLY B O   1 
ATOM   2514 N N   . VAL B 1 45  ? 15.610  -46.347 49.011  1.00 60.70  ?  39  VAL B N   1 
ATOM   2515 C CA  . VAL B 1 45  ? 15.691  -47.323 47.933  1.00 58.87  ?  39  VAL B CA  1 
ATOM   2516 C C   . VAL B 1 45  ? 14.274  -47.721 47.554  1.00 64.12  ?  39  VAL B C   1 
ATOM   2517 O O   . VAL B 1 45  ? 13.428  -47.895 48.436  1.00 67.07  ?  39  VAL B O   1 
ATOM   2518 C CB  . VAL B 1 45  ? 16.512  -48.555 48.367  1.00 64.27  ?  39  VAL B CB  1 
ATOM   2519 C CG1 . VAL B 1 45  ? 16.769  -49.489 47.192  1.00 56.14  ?  39  VAL B CG1 1 
ATOM   2520 C CG2 . VAL B 1 45  ? 17.816  -48.102 48.986  1.00 63.42  ?  39  VAL B CG2 1 
ATOM   2521 N N   . VAL B 1 46  ? 14.006  -47.844 46.252  1.00 60.75  ?  40  VAL B N   1 
ATOM   2522 C CA  . VAL B 1 46  ? 12.666  -48.143 45.745  1.00 62.46  ?  40  VAL B CA  1 
ATOM   2523 C C   . VAL B 1 46  ? 12.706  -49.507 45.073  1.00 63.98  ?  40  VAL B C   1 
ATOM   2524 O O   . VAL B 1 46  ? 13.444  -49.694 44.099  1.00 65.08  ?  40  VAL B O   1 
ATOM   2525 C CB  . VAL B 1 46  ? 12.164  -47.075 44.751  1.00 66.90  ?  40  VAL B CB  1 
ATOM   2526 C CG1 . VAL B 1 46  ? 10.884  -47.566 44.046  1.00 60.54  ?  40  VAL B CG1 1 
ATOM   2527 C CG2 . VAL B 1 46  ? 11.923  -45.726 45.440  1.00 62.68  ?  40  VAL B CG2 1 
ATOM   2528 N N   . ARG B 1 47  ? 11.907  -50.456 45.571  1.00 65.48  ?  41  ARG B N   1 
ATOM   2529 C CA  . ARG B 1 47  ? 11.883  -51.801 44.997  1.00 65.93  ?  41  ARG B CA  1 
ATOM   2530 C C   . ARG B 1 47  ? 10.468  -52.185 44.598  1.00 67.80  ?  41  ARG B C   1 
ATOM   2531 O O   . ARG B 1 47  ? 9.488   -51.572 45.030  1.00 68.53  ?  41  ARG B O   1 
ATOM   2532 C CB  . ARG B 1 47  ? 12.435  -52.846 45.970  1.00 65.66  ?  41  ARG B CB  1 
ATOM   2533 C CG  . ARG B 1 47  ? 13.559  -52.305 46.856  1.00 68.87  ?  41  ARG B CG  1 
ATOM   2534 C CD  . ARG B 1 47  ? 14.167  -53.376 47.729  1.00 65.91  ?  41  ARG B CD  1 
ATOM   2535 N NE  . ARG B 1 47  ? 14.796  -54.422 46.936  1.00 70.93  ?  41  ARG B NE  1 
ATOM   2536 C CZ  . ARG B 1 47  ? 15.452  -55.456 47.446  1.00 69.05  ?  41  ARG B CZ  1 
ATOM   2537 N NH1 . ARG B 1 47  ? 15.483  -55.683 48.751  1.00 68.01  ?  41  ARG B NH1 1 
ATOM   2538 N NH2 . ARG B 1 47  ? 16.129  -56.259 46.629  1.00 69.40  ?  41  ARG B NH2 1 
ATOM   2539 N N   . ARG B 1 48  ? 10.373  -53.208 43.749  1.00 72.06  ?  42  ARG B N   1 
ATOM   2540 C CA  . ARG B 1 48  ? 9.089   -53.858 43.514  1.00 72.34  ?  42  ARG B CA  1 
ATOM   2541 C C   . ARG B 1 48  ? 8.495   -54.296 44.846  1.00 77.50  ?  42  ARG B C   1 
ATOM   2542 O O   . ARG B 1 48  ? 9.221   -54.744 45.739  1.00 79.49  ?  42  ARG B O   1 
ATOM   2543 C CB  . ARG B 1 48  ? 9.259   -55.075 42.609  1.00 66.72  ?  42  ARG B CB  1 
ATOM   2544 C CG  . ARG B 1 48  ? 9.686   -54.770 41.197  1.00 67.77  ?  42  ARG B CG  1 
ATOM   2545 C CD  . ARG B 1 48  ? 10.220  -56.032 40.554  1.00 67.46  ?  42  ARG B CD  1 
ATOM   2546 N NE  . ARG B 1 48  ? 11.401  -56.522 41.258  1.00 66.83  ?  42  ARG B NE  1 
ATOM   2547 C CZ  . ARG B 1 48  ? 12.116  -57.564 40.864  1.00 65.67  ?  42  ARG B CZ  1 
ATOM   2548 N NH1 . ARG B 1 48  ? 11.778  -58.263 39.793  1.00 65.83  ?  42  ARG B NH1 1 
ATOM   2549 N NH2 . ARG B 1 48  ? 13.198  -57.910 41.558  1.00 62.67  ?  42  ARG B NH2 1 
ATOM   2550 N N   . GLN B 1 49  ? 7.171   -54.160 44.986  1.00 74.63  ?  43  GLN B N   1 
ATOM   2551 C CA  . GLN B 1 49  ? 6.526   -54.595 46.223  1.00 76.67  ?  43  GLN B CA  1 
ATOM   2552 C C   . GLN B 1 49  ? 6.841   -56.059 46.515  1.00 80.05  ?  43  GLN B C   1 
ATOM   2553 O O   . GLN B 1 49  ? 7.040   -56.444 47.676  1.00 80.59  ?  43  GLN B O   1 
ATOM   2554 C CB  . GLN B 1 49  ? 5.016   -54.372 46.136  1.00 78.50  ?  43  GLN B CB  1 
ATOM   2555 C CG  . GLN B 1 49  ? 4.384   -53.895 47.429  1.00 81.00  ?  43  GLN B CG  1 
ATOM   2556 C CD  . GLN B 1 49  ? 4.585   -54.888 48.548  1.00 86.84  ?  43  GLN B CD  1 
ATOM   2557 O OE1 . GLN B 1 49  ? 4.261   -56.070 48.408  1.00 93.52  ?  43  GLN B OE1 1 
ATOM   2558 N NE2 . GLN B 1 49  ? 5.130   -54.422 49.667  1.00 87.39  ?  43  GLN B NE2 1 
ATOM   2559 N N   . SER B 1 50  ? 6.931   -56.886 45.469  1.00 73.86  ?  44  SER B N   1 
ATOM   2560 C CA  . SER B 1 50  ? 7.243   -58.290 45.681  1.00 72.31  ?  44  SER B CA  1 
ATOM   2561 C C   . SER B 1 50  ? 8.561   -58.458 46.427  1.00 81.19  ?  44  SER B C   1 
ATOM   2562 O O   . SER B 1 50  ? 8.720   -59.401 47.217  1.00 86.18  ?  44  SER B O   1 
ATOM   2563 C CB  . SER B 1 50  ? 7.271   -59.012 44.339  1.00 74.05  ?  44  SER B CB  1 
ATOM   2564 O OG  . SER B 1 50  ? 8.595   -59.226 43.891  1.00 78.28  ?  44  SER B OG  1 
ATOM   2565 N N   . SER B 1 51  ? 9.506   -57.539 46.213  1.00 81.19  ?  45  SER B N   1 
ATOM   2566 C CA  . SER B 1 51  ? 10.805  -57.613 46.869  1.00 77.71  ?  45  SER B CA  1 
ATOM   2567 C C   . SER B 1 51  ? 10.772  -57.094 48.300  1.00 77.16  ?  45  SER B C   1 
ATOM   2568 O O   . SER B 1 51  ? 11.622  -57.483 49.102  1.00 81.88  ?  45  SER B O   1 
ATOM   2569 C CB  . SER B 1 51  ? 11.844  -56.830 46.059  1.00 74.95  ?  45  SER B CB  1 
ATOM   2570 O OG  . SER B 1 51  ? 12.118  -57.454 44.807  1.00 73.89  ?  45  SER B OG  1 
ATOM   2571 N N   . LEU B 1 52  ? 9.820   -56.224 48.641  1.00 80.11  ?  46  LEU B N   1 
ATOM   2572 C CA  . LEU B 1 52  ? 9.738   -55.727 50.008  1.00 78.67  ?  46  LEU B CA  1 
ATOM   2573 C C   . LEU B 1 52  ? 9.368   -56.833 50.988  1.00 82.59  ?  46  LEU B C   1 
ATOM   2574 O O   . LEU B 1 52  ? 9.700   -56.739 52.174  1.00 82.62  ?  46  LEU B O   1 
ATOM   2575 C CB  . LEU B 1 52  ? 8.722   -54.592 50.084  1.00 79.06  ?  46  LEU B CB  1 
ATOM   2576 C CG  . LEU B 1 52  ? 9.095   -53.303 49.363  1.00 80.45  ?  46  LEU B CG  1 
ATOM   2577 C CD1 . LEU B 1 52  ? 7.962   -52.294 49.461  1.00 70.66  ?  46  LEU B CD1 1 
ATOM   2578 C CD2 . LEU B 1 52  ? 10.397  -52.723 49.925  1.00 74.84  ?  46  LEU B CD2 1 
ATOM   2579 N N   . GLU B 1 53  ? 8.668   -57.874 50.516  1.00 85.66  ?  47  GLU B N   1 
ATOM   2580 C CA  . GLU B 1 53  ? 8.267   -58.984 51.375  1.00 84.98  ?  47  GLU B CA  1 
ATOM   2581 C C   . GLU B 1 53  ? 9.448   -59.858 51.775  1.00 87.59  ?  47  GLU B C   1 
ATOM   2582 O O   . GLU B 1 53  ? 9.385   -60.535 52.806  1.00 87.17  ?  47  GLU B O   1 
ATOM   2583 C CB  . GLU B 1 53  ? 7.205   -59.835 50.675  1.00 83.78  ?  47  GLU B CB  1 
ATOM   2584 C CG  . GLU B 1 53  ? 6.056   -59.040 50.046  1.00 90.67  ?  47  GLU B CG  1 
ATOM   2585 C CD  . GLU B 1 53  ? 4.948   -58.665 51.037  1.00 98.42  ?  47  GLU B CD  1 
ATOM   2586 O OE1 . GLU B 1 53  ? 4.613   -59.495 51.920  1.00 100.34 ?  47  GLU B OE1 1 
ATOM   2587 O OE2 . GLU B 1 53  ? 4.405   -57.537 50.925  1.00 97.44  -1 47  GLU B OE2 1 
ATOM   2588 N N   . LYS B 1 54  ? 10.517  -59.852 50.984  1.00 87.48  ?  48  LYS B N   1 
ATOM   2589 C CA  . LYS B 1 54  ? 11.737  -60.568 51.301  1.00 85.20  ?  48  LYS B CA  1 
ATOM   2590 C C   . LYS B 1 54  ? 12.430  -59.908 52.499  1.00 85.27  ?  48  LYS B C   1 
ATOM   2591 O O   . LYS B 1 54  ? 12.091  -58.785 52.886  1.00 79.66  ?  48  LYS B O   1 
ATOM   2592 C CB  . LYS B 1 54  ? 12.644  -60.594 50.070  1.00 86.75  ?  48  LYS B CB  1 
ATOM   2593 C CG  . LYS B 1 54  ? 12.334  -61.714 49.101  1.00 87.93  ?  48  LYS B CG  1 
ATOM   2594 C CD  . LYS B 1 54  ? 12.850  -61.404 47.698  1.00 95.14  ?  48  LYS B CD  1 
ATOM   2595 C CE  . LYS B 1 54  ? 12.008  -62.108 46.630  1.00 97.73  ?  48  LYS B CE  1 
ATOM   2596 N NZ  . LYS B 1 54  ? 12.792  -63.107 45.842  1.00 99.23  ?  48  LYS B NZ  1 
ATOM   2597 N N   . PRO B 1 55  ? 13.403  -60.586 53.116  1.00 80.88  ?  49  PRO B N   1 
ATOM   2598 C CA  . PRO B 1 55  ? 14.048  -60.024 54.308  1.00 83.45  ?  49  PRO B CA  1 
ATOM   2599 C C   . PRO B 1 55  ? 14.979  -58.873 53.967  1.00 85.45  ?  49  PRO B C   1 
ATOM   2600 O O   . PRO B 1 55  ? 15.567  -58.812 52.886  1.00 86.62  ?  49  PRO B O   1 
ATOM   2601 C CB  . PRO B 1 55  ? 14.837  -61.208 54.884  1.00 84.04  ?  49  PRO B CB  1 
ATOM   2602 C CG  . PRO B 1 55  ? 14.266  -62.428 54.220  1.00 83.39  ?  49  PRO B CG  1 
ATOM   2603 C CD  . PRO B 1 55  ? 13.851  -61.966 52.863  1.00 82.46  ?  49  PRO B CD  1 
ATOM   2604 N N   . LEU B 1 56  ? 15.119  -57.953 54.922  1.00 81.81  ?  50  LEU B N   1 
ATOM   2605 C CA  . LEU B 1 56  ? 15.909  -56.726 54.669  1.00 80.92  ?  50  LEU B CA  1 
ATOM   2606 C C   . LEU B 1 56  ? 17.403  -57.027 54.638  1.00 84.22  ?  50  LEU B C   1 
ATOM   2607 O O   . LEU B 1 56  ? 17.905  -57.653 55.583  1.00 88.25  ?  50  LEU B O   1 
ATOM   2608 C CB  . LEU B 1 56  ? 15.592  -55.710 55.762  1.00 75.79  ?  50  LEU B CB  1 
ATOM   2609 C CG  . LEU B 1 56  ? 16.034  -54.272 55.483  1.00 80.48  ?  50  LEU B CG  1 
ATOM   2610 C CD1 . LEU B 1 56  ? 15.162  -53.674 54.398  1.00 79.07  ?  50  LEU B CD1 1 
ATOM   2611 C CD2 . LEU B 1 56  ? 15.962  -53.437 56.747  1.00 80.44  ?  50  LEU B CD2 1 
ATOM   2612 N N   . PRO B 1 57  ? 18.127  -56.604 53.587  1.00 82.78  ?  51  PRO B N   1 
ATOM   2613 C CA  . PRO B 1 57  ? 19.569  -56.753 53.579  1.00 78.29  ?  51  PRO B CA  1 
ATOM   2614 C C   . PRO B 1 57  ? 20.132  -55.979 54.751  1.00 80.09  ?  51  PRO B C   1 
ATOM   2615 O O   . PRO B 1 57  ? 19.595  -54.920 55.106  1.00 83.11  ?  51  PRO B O   1 
ATOM   2616 C CB  . PRO B 1 57  ? 19.911  -56.118 52.247  1.00 74.82  ?  51  PRO B CB  1 
ATOM   2617 C CG  . PRO B 1 57  ? 18.687  -56.349 51.403  1.00 72.92  ?  51  PRO B CG  1 
ATOM   2618 C CD  . PRO B 1 57  ? 17.574  -56.040 52.376  1.00 78.41  ?  51  PRO B CD  1 
ATOM   2619 N N   . ARG B 1 58  ? 21.206  -56.484 55.345  1.00 30.00  ?  52  ARG B N   1 
ATOM   2620 C CA  . ARG B 1 58  ? 21.804  -55.821 56.528  1.00 30.00  ?  52  ARG B CA  1 
ATOM   2621 C C   . ARG B 1 58  ? 22.213  -54.393 56.165  1.00 30.00  ?  52  ARG B C   1 
ATOM   2622 O O   . ARG B 1 58  ? 22.071  -53.501 57.017  1.00 30.00  ?  52  ARG B O   1 
ATOM   2623 C CB  . ARG B 1 58  ? 23.039  -56.594 56.991  1.00 30.00  ?  52  ARG B CB  1 
ATOM   2624 C CG  . ARG B 1 58  ? 22.978  -58.090 56.717  1.00 30.00  ?  52  ARG B CG  1 
ATOM   2625 C CD  . ARG B 1 58  ? 23.571  -58.867 57.880  1.00 30.00  ?  52  ARG B CD  1 
ATOM   2626 N NE  . ARG B 1 58  ? 25.036  -58.839 57.849  1.00 30.00  ?  52  ARG B NE  1 
ATOM   2627 C CZ  . ARG B 1 58  ? 25.772  -59.756 57.233  1.00 30.00  ?  52  ARG B CZ  1 
ATOM   2628 N NH1 . ARG B 1 58  ? 27.070  -59.572 57.073  1.00 30.00  ?  52  ARG B NH1 1 
ATOM   2629 N NH2 . ARG B 1 58  ? 25.203  -60.860 56.782  1.00 30.00  ?  52  ARG B NH2 1 
ATOM   2630 N N   . GLU B 1 59  ? 22.704  -54.197 54.946  1.00 81.82  ?  53  GLU B N   1 
ATOM   2631 C CA  . GLU B 1 59  ? 23.192  -52.863 54.520  1.00 82.58  ?  53  GLU B CA  1 
ATOM   2632 C C   . GLU B 1 59  ? 22.018  -51.884 54.454  1.00 79.03  ?  53  GLU B C   1 
ATOM   2633 O O   . GLU B 1 59  ? 22.260  -50.667 54.467  1.00 81.65  ?  53  GLU B O   1 
ATOM   2634 C CB  . GLU B 1 59  ? 23.860  -53.017 53.158  1.00 73.79  ?  53  GLU B CB  1 
ATOM   2635 C CG  . GLU B 1 59  ? 22.934  -53.627 52.113  1.00 75.32  ?  53  GLU B CG  1 
ATOM   2636 C CD  . GLU B 1 59  ? 23.204  -55.091 51.835  1.00 79.84  ?  53  GLU B CD  1 
ATOM   2637 O OE1 . GLU B 1 59  ? 23.613  -55.800 52.777  1.00 76.90  ?  53  GLU B OE1 1 
ATOM   2638 O OE2 . GLU B 1 59  ? 22.997  -55.518 50.682  1.00 80.85  -1 53  GLU B OE2 1 
ATOM   2639 N N   . LEU B 1 60  ? 20.798  -52.404 54.401  1.00 77.15  ?  54  LEU B N   1 
ATOM   2640 C CA  . LEU B 1 60  ? 19.616  -51.525 54.245  1.00 81.23  ?  54  LEU B CA  1 
ATOM   2641 C C   . LEU B 1 60  ? 19.013  -51.209 55.621  1.00 82.45  ?  54  LEU B C   1 
ATOM   2642 O O   . LEU B 1 60  ? 18.026  -50.457 55.671  1.00 82.96  ?  54  LEU B O   1 
ATOM   2643 C CB  . LEU B 1 60  ? 18.625  -52.215 53.310  1.00 74.92  ?  54  LEU B CB  1 
ATOM   2644 C CG  . LEU B 1 60  ? 19.008  -52.238 51.828  1.00 71.24  ?  54  LEU B CG  1 
ATOM   2645 C CD1 . LEU B 1 60  ? 17.829  -52.641 50.966  1.00 66.71  ?  54  LEU B CD1 1 
ATOM   2646 C CD2 . LEU B 1 60  ? 19.509  -50.873 51.418  1.00 68.91  ?  54  LEU B CD2 1 
ATOM   2647 N N   . HIS B 1 61  ? 19.586  -51.748 56.694  1.00 80.68  ?  55  HIS B N   1 
ATOM   2648 C CA  . HIS B 1 61  ? 19.084  -51.394 58.018  1.00 81.92  ?  55  HIS B CA  1 
ATOM   2649 C C   . HIS B 1 61  ? 19.226  -49.893 58.242  1.00 79.07  ?  55  HIS B C   1 
ATOM   2650 O O   . HIS B 1 61  ? 20.316  -49.332 58.095  1.00 81.90  ?  55  HIS B O   1 
ATOM   2651 C CB  . HIS B 1 61  ? 19.839  -52.176 59.093  1.00 85.79  ?  55  HIS B CB  1 
ATOM   2652 C CG  . HIS B 1 61  ? 19.335  -53.575 59.292  1.00 94.34  ?  55  HIS B CG  1 
ATOM   2653 N ND1 . HIS B 1 61  ? 19.020  -54.417 58.242  1.00 93.12  ?  55  HIS B ND1 1 
ATOM   2654 C CD2 . HIS B 1 61  ? 19.121  -54.290 60.423  1.00 96.64  ?  55  HIS B CD2 1 
ATOM   2655 C CE1 . HIS B 1 61  ? 18.613  -55.581 58.720  1.00 91.01  ?  55  HIS B CE1 1 
ATOM   2656 N NE2 . HIS B 1 61  ? 18.670  -55.532 60.040  1.00 95.85  ?  55  HIS B NE2 1 
ATOM   2657 N N   . GLY B 1 62  ? 18.111  -49.241 58.567  1.00 75.33  ?  56  GLY B N   1 
ATOM   2658 C CA  . GLY B 1 62  ? 18.076  -47.806 58.716  1.00 67.33  ?  56  GLY B CA  1 
ATOM   2659 C C   . GLY B 1 62  ? 17.835  -47.041 57.437  1.00 67.99  ?  56  GLY B C   1 
ATOM   2660 O O   . GLY B 1 62  ? 17.928  -45.812 57.445  1.00 71.58  ?  56  GLY B O   1 
ATOM   2661 N N   . VAL B 1 63  ? 17.545  -47.719 56.332  1.00 66.42  ?  57  VAL B N   1 
ATOM   2662 C CA  . VAL B 1 63  ? 17.320  -47.073 55.045  1.00 66.48  ?  57  VAL B CA  1 
ATOM   2663 C C   . VAL B 1 63  ? 15.846  -47.189 54.703  1.00 65.10  ?  57  VAL B C   1 
ATOM   2664 O O   . VAL B 1 63  ? 15.263  -48.269 54.825  1.00 67.17  ?  57  VAL B O   1 
ATOM   2665 C CB  . VAL B 1 63  ? 18.189  -47.693 53.936  1.00 67.57  ?  57  VAL B CB  1 
ATOM   2666 C CG1 . VAL B 1 63  ? 17.739  -47.204 52.568  1.00 64.85  ?  57  VAL B CG1 1 
ATOM   2667 C CG2 . VAL B 1 63  ? 19.632  -47.338 54.149  1.00 67.82  ?  57  VAL B CG2 1 
ATOM   2668 N N   . SER B 1 64  ? 15.244  -46.083 54.278  1.00 61.91  ?  58  SER B N   1 
ATOM   2669 C CA  . SER B 1 64  ? 13.847  -46.123 53.865  1.00 64.35  ?  58  SER B CA  1 
ATOM   2670 C C   . SER B 1 64  ? 13.783  -46.908 52.572  1.00 64.61  ?  58  SER B C   1 
ATOM   2671 O O   . SER B 1 64  ? 14.174  -46.421 51.508  1.00 65.31  ?  58  SER B O   1 
ATOM   2672 C CB  . SER B 1 64  ? 13.270  -44.723 53.701  1.00 57.18  ?  58  SER B CB  1 
ATOM   2673 O OG  . SER B 1 64  ? 13.689  -43.894 54.765  1.00 62.20  ?  58  SER B OG  1 
ATOM   2674 N N   . VAL B 1 65  ? 13.338  -48.151 52.673  1.00 62.53  ?  59  VAL B N   1 
ATOM   2675 C CA  . VAL B 1 65  ? 13.118  -49.003 51.519  1.00 63.26  ?  59  VAL B CA  1 
ATOM   2676 C C   . VAL B 1 65  ? 11.624  -49.010 51.273  1.00 63.05  ?  59  VAL B C   1 
ATOM   2677 O O   . VAL B 1 65  ? 10.837  -49.234 52.200  1.00 69.96  ?  59  VAL B O   1 
ATOM   2678 C CB  . VAL B 1 65  ? 13.649  -50.425 51.760  1.00 63.36  ?  59  VAL B CB  1 
ATOM   2679 C CG1 . VAL B 1 65  ? 13.768  -51.168 50.437  1.00 61.17  ?  59  VAL B CG1 1 
ATOM   2680 C CG2 . VAL B 1 65  ? 14.971  -50.374 52.494  1.00 59.17  ?  59  VAL B CG2 1 
ATOM   2681 N N   . VAL B 1 66  ? 11.225  -48.766 50.037  1.00 63.55  ?  60  VAL B N   1 
ATOM   2682 C CA  . VAL B 1 66  ? 9.835   -48.413 49.800  1.00 62.85  ?  60  VAL B CA  1 
ATOM   2683 C C   . VAL B 1 66  ? 9.478   -48.788 48.378  1.00 63.50  ?  60  VAL B C   1 
ATOM   2684 O O   . VAL B 1 66  ? 10.357  -49.138 47.579  1.00 62.85  ?  60  VAL B O   1 
ATOM   2685 C CB  . VAL B 1 66  ? 9.618   -46.922 50.103  1.00 61.32  ?  60  VAL B CB  1 
ATOM   2686 C CG1 . VAL B 1 66  ? 9.918   -46.073 48.884  1.00 66.84  ?  60  VAL B CG1 1 
ATOM   2687 C CG2 . VAL B 1 66  ? 8.243   -46.677 50.624  1.00 75.10  ?  60  VAL B CG2 1 
ATOM   2688 N N   . SER B 1 67  ? 8.188   -48.752 48.064  1.00 65.31  ?  61  SER B N   1 
ATOM   2689 C CA  . SER B 1 67  ? 7.704   -49.157 46.751  1.00 65.39  ?  61  SER B CA  1 
ATOM   2690 C C   . SER B 1 67  ? 7.499   -47.980 45.816  1.00 65.47  ?  61  SER B C   1 
ATOM   2691 O O   . SER B 1 67  ? 7.249   -48.192 44.627  1.00 67.51  ?  61  SER B O   1 
ATOM   2692 C CB  . SER B 1 67  ? 6.374   -49.893 46.882  1.00 63.56  ?  61  SER B CB  1 
ATOM   2693 O OG  . SER B 1 67  ? 5.392   -49.004 47.420  1.00 65.87  ?  61  SER B OG  1 
ATOM   2694 N N   . ASP B 1 68  ? 7.568   -46.753 46.327  1.00 66.03  ?  62  ASP B N   1 
ATOM   2695 C CA  . ASP B 1 68  ? 7.307   -45.584 45.502  1.00 69.05  ?  62  ASP B CA  1 
ATOM   2696 C C   . ASP B 1 68  ? 8.031   -44.371 46.057  1.00 67.01  ?  62  ASP B C   1 
ATOM   2697 O O   . ASP B 1 68  ? 7.964   -44.091 47.259  1.00 66.08  ?  62  ASP B O   1 
ATOM   2698 C CB  . ASP B 1 68  ? 5.811   -45.274 45.392  1.00 67.77  ?  62  ASP B CB  1 
ATOM   2699 C CG  . ASP B 1 68  ? 5.509   -44.315 44.254  1.00 76.08  ?  62  ASP B CG  1 
ATOM   2700 O OD1 . ASP B 1 68  ? 5.530   -43.067 44.468  1.00 75.28  ?  62  ASP B OD1 1 
ATOM   2701 O OD2 . ASP B 1 68  ? 5.294   -44.822 43.129  1.00 83.01  -1 62  ASP B OD2 1 
ATOM   2702 N N   . VAL B 1 69  ? 8.661   -43.621 45.147  1.00 67.89  ?  63  VAL B N   1 
ATOM   2703 C CA  . VAL B 1 69  ? 9.568   -42.538 45.521  1.00 71.84  ?  63  VAL B CA  1 
ATOM   2704 C C   . VAL B 1 69  ? 8.830   -41.461 46.307  1.00 68.39  ?  63  VAL B C   1 
ATOM   2705 O O   . VAL B 1 69  ? 9.451   -40.713 47.072  1.00 71.28  ?  63  VAL B O   1 
ATOM   2706 C CB  . VAL B 1 69  ? 10.241  -41.965 44.244  1.00 71.31  ?  63  VAL B CB  1 
ATOM   2707 C CG1 . VAL B 1 69  ? 9.175   -41.519 43.202  1.00 76.22  ?  63  VAL B CG1 1 
ATOM   2708 C CG2 . VAL B 1 69  ? 11.251  -40.895 44.564  1.00 60.78  ?  63  VAL B CG2 1 
ATOM   2709 N N   . SER B 1 70  ? 7.501   -41.397 46.165  1.00 70.29  ?  64  SER B N   1 
ATOM   2710 C CA  . SER B 1 70  ? 6.690   -40.413 46.883  1.00 70.70  ?  64  SER B CA  1 
ATOM   2711 C C   . SER B 1 70  ? 6.809   -40.539 48.390  1.00 67.70  ?  64  SER B C   1 
ATOM   2712 O O   . SER B 1 70  ? 6.508   -39.577 49.101  1.00 71.16  ?  64  SER B O   1 
ATOM   2713 C CB  . SER B 1 70  ? 5.230   -40.537 46.468  1.00 68.10  ?  64  SER B CB  1 
ATOM   2714 O OG  . SER B 1 70  ? 4.891   -41.902 46.273  1.00 73.28  ?  64  SER B OG  1 
ATOM   2715 N N   . ALA B 1 71  ? 7.246   -41.692 48.889  1.00 69.27  ?  65  ALA B N   1 
ATOM   2716 C CA  . ALA B 1 71  ? 7.407   -41.927 50.317  1.00 65.06  ?  65  ALA B CA  1 
ATOM   2717 C C   . ALA B 1 71  ? 8.790   -41.572 50.834  1.00 71.99  ?  65  ALA B C   1 
ATOM   2718 O O   . ALA B 1 71  ? 9.069   -41.804 52.017  1.00 74.59  ?  65  ALA B O   1 
ATOM   2719 C CB  . ALA B 1 71  ? 7.115   -43.391 50.640  1.00 65.36  ?  65  ALA B CB  1 
ATOM   2720 N N   . LEU B 1 72  ? 9.672   -41.046 49.982  1.00 73.08  ?  66  LEU B N   1 
ATOM   2721 C CA  . LEU B 1 72  ? 11.034  -40.725 50.381  1.00 71.42  ?  66  LEU B CA  1 
ATOM   2722 C C   . LEU B 1 72  ? 11.193  -39.240 50.685  1.00 71.73  ?  66  LEU B C   1 
ATOM   2723 O O   . LEU B 1 72  ? 12.318  -38.756 50.869  1.00 74.29  ?  66  LEU B O   1 
ATOM   2724 C CB  . LEU B 1 72  ? 12.018  -41.175 49.298  1.00 66.06  ?  66  LEU B CB  1 
ATOM   2725 C CG  . LEU B 1 72  ? 12.135  -42.680 49.079  1.00 64.52  ?  66  LEU B CG  1 
ATOM   2726 C CD1 . LEU B 1 72  ? 13.260  -43.026 48.087  1.00 60.69  ?  66  LEU B CD1 1 
ATOM   2727 C CD2 . LEU B 1 72  ? 12.352  -43.373 50.421  1.00 64.96  ?  66  LEU B CD2 1 
ATOM   2728 N N   . GLY B 1 73  ? 10.092  -38.513 50.758  1.00 67.69  ?  67  GLY B N   1 
ATOM   2729 C CA  . GLY B 1 73  ? 10.189  -37.087 50.940  1.00 73.48  ?  67  GLY B CA  1 
ATOM   2730 C C   . GLY B 1 73  ? 10.730  -36.429 49.684  1.00 71.08  ?  67  GLY B C   1 
ATOM   2731 O O   . GLY B 1 73  ? 10.475  -36.872 48.555  1.00 69.79  ?  67  GLY B O   1 
ATOM   2732 N N   . GLN B 1 74  ? 11.473  -35.345 49.893  1.00 70.27  ?  68  GLN B N   1 
ATOM   2733 C CA  . GLN B 1 74  ? 12.131  -34.652 48.791  1.00 72.94  ?  68  GLN B CA  1 
ATOM   2734 C C   . GLN B 1 74  ? 13.132  -35.568 48.090  1.00 71.41  ?  68  GLN B C   1 
ATOM   2735 O O   . GLN B 1 74  ? 13.990  -36.185 48.728  1.00 69.73  ?  68  GLN B O   1 
ATOM   2736 C CB  . GLN B 1 74  ? 12.842  -33.406 49.309  1.00 71.57  ?  68  GLN B CB  1 
ATOM   2737 C CG  . GLN B 1 74  ? 13.706  -32.727 48.260  1.00 73.91  ?  68  GLN B CG  1 
ATOM   2738 C CD  . GLN B 1 74  ? 12.881  -32.232 47.083  1.00 84.07  ?  68  GLN B CD  1 
ATOM   2739 O OE1 . GLN B 1 74  ? 11.701  -31.883 47.233  1.00 88.23  ?  68  GLN B OE1 1 
ATOM   2740 N NE2 . GLN B 1 74  ? 13.493  -32.204 45.903  1.00 80.84  ?  68  GLN B NE2 1 
ATOM   2741 N N   . VAL B 1 75  ? 13.019  -35.651 46.772  1.00 65.90  ?  69  VAL B N   1 
ATOM   2742 C CA  . VAL B 1 75  ? 13.909  -36.458 45.961  1.00 66.88  ?  69  VAL B CA  1 
ATOM   2743 C C   . VAL B 1 75  ? 14.320  -35.607 44.765  1.00 69.53  ?  69  VAL B C   1 
ATOM   2744 O O   . VAL B 1 75  ? 13.514  -35.401 43.850  1.00 69.17  ?  69  VAL B O   1 
ATOM   2745 C CB  . VAL B 1 75  ? 13.249  -37.760 45.487  1.00 64.21  ?  69  VAL B CB  1 
ATOM   2746 C CG1 . VAL B 1 75  ? 14.213  -38.526 44.559  1.00 62.01  ?  69  VAL B CG1 1 
ATOM   2747 C CG2 . VAL B 1 75  ? 12.845  -38.610 46.677  1.00 67.26  ?  69  VAL B CG2 1 
ATOM   2748 N N   . ASP B 1 76  ? 15.577  -35.137 44.751  1.00 59.60  ?  70  ASP B N   1 
ATOM   2749 C CA  . ASP B 1 76  ? 16.055  -34.360 43.610  1.00 55.58  ?  70  ASP B CA  1 
ATOM   2750 C C   . ASP B 1 76  ? 16.376  -35.232 42.401  1.00 57.96  ?  70  ASP B C   1 
ATOM   2751 O O   . ASP B 1 76  ? 16.068  -34.843 41.270  1.00 57.24  ?  70  ASP B O   1 
ATOM   2752 C CB  . ASP B 1 76  ? 17.283  -33.535 43.997  1.00 54.93  ?  70  ASP B CB  1 
ATOM   2753 C CG  . ASP B 1 76  ? 17.013  -32.620 45.162  1.00 62.24  ?  70  ASP B CG  1 
ATOM   2754 O OD1 . ASP B 1 76  ? 16.135  -31.729 45.043  1.00 66.72  ?  70  ASP B OD1 1 
ATOM   2755 O OD2 . ASP B 1 76  ? 17.661  -32.797 46.213  1.00 66.08  -1 70  ASP B OD2 1 
ATOM   2756 N N   . VAL B 1 77  ? 17.018  -36.393 42.604  1.00 57.19  ?  71  VAL B N   1 
ATOM   2757 C CA  . VAL B 1 77  ? 17.485  -37.226 41.500  1.00 53.04  ?  71  VAL B CA  1 
ATOM   2758 C C   . VAL B 1 77  ? 17.209  -38.681 41.830  1.00 57.66  ?  71  VAL B C   1 
ATOM   2759 O O   . VAL B 1 77  ? 17.381  -39.114 42.976  1.00 58.71  ?  71  VAL B O   1 
ATOM   2760 C CB  . VAL B 1 77  ? 18.999  -37.063 41.193  1.00 54.30  ?  71  VAL B CB  1 
ATOM   2761 C CG1 . VAL B 1 77  ? 19.319  -37.698 39.836  1.00 57.77  ?  71  VAL B CG1 1 
ATOM   2762 C CG2 . VAL B 1 77  ? 19.479  -35.613 41.232  1.00 48.60  ?  71  VAL B CG2 1 
ATOM   2763 N N   . ALA B 1 78  ? 16.826  -39.448 40.812  1.00 54.11  ?  72  ALA B N   1 
ATOM   2764 C CA  . ALA B 1 78  ? 16.624  -40.880 40.937  1.00 51.09  ?  72  ALA B CA  1 
ATOM   2765 C C   . ALA B 1 78  ? 17.619  -41.577 40.026  1.00 59.41  ?  72  ALA B C   1 
ATOM   2766 O O   . ALA B 1 78  ? 17.710  -41.248 38.838  1.00 61.39  ?  72  ALA B O   1 
ATOM   2767 C CB  . ALA B 1 78  ? 15.196  -41.280 40.565  1.00 54.43  ?  72  ALA B CB  1 
ATOM   2768 N N   . VAL B 1 79  ? 18.372  -42.518 40.585  1.00 55.79  ?  73  VAL B N   1 
ATOM   2769 C CA  . VAL B 1 79  ? 19.351  -43.294 39.847  1.00 51.76  ?  73  VAL B CA  1 
ATOM   2770 C C   . VAL B 1 79  ? 18.708  -44.642 39.548  1.00 59.13  ?  73  VAL B C   1 
ATOM   2771 O O   . VAL B 1 79  ? 18.390  -45.414 40.462  1.00 59.34  ?  73  VAL B O   1 
ATOM   2772 C CB  . VAL B 1 79  ? 20.655  -43.428 40.644  1.00 59.08  ?  73  VAL B CB  1 
ATOM   2773 C CG1 . VAL B 1 79  ? 21.678  -44.294 39.907  1.00 57.16  ?  73  VAL B CG1 1 
ATOM   2774 C CG2 . VAL B 1 79  ? 21.215  -42.039 40.962  1.00 52.38  ?  73  VAL B CG2 1 
ATOM   2775 N N   . LEU B 1 80  ? 18.467  -44.908 38.269  1.00 57.92  ?  74  LEU B N   1 
ATOM   2776 C CA  . LEU B 1 80  ? 17.782  -46.122 37.847  1.00 55.95  ?  74  LEU B CA  1 
ATOM   2777 C C   . LEU B 1 80  ? 18.798  -47.245 37.679  1.00 59.28  ?  74  LEU B C   1 
ATOM   2778 O O   . LEU B 1 80  ? 19.691  -47.163 36.829  1.00 62.26  ?  74  LEU B O   1 
ATOM   2779 C CB  . LEU B 1 80  ? 17.011  -45.881 36.548  1.00 60.74  ?  74  LEU B CB  1 
ATOM   2780 C CG  . LEU B 1 80  ? 16.303  -44.522 36.378  1.00 59.30  ?  74  LEU B CG  1 
ATOM   2781 C CD1 . LEU B 1 80  ? 15.536  -44.507 35.095  1.00 58.22  ?  74  LEU B CD1 1 
ATOM   2782 C CD2 . LEU B 1 80  ? 15.365  -44.209 37.524  1.00 55.62  ?  74  LEU B CD2 1 
ATOM   2783 N N   . CYS B 1 81  ? 18.668  -48.285 38.498  1.00 58.47  ?  75  CYS B N   1 
ATOM   2784 C CA  . CYS B 1 81  ? 19.481  -49.490 38.402  1.00 59.38  ?  75  CYS B CA  1 
ATOM   2785 C C   . CYS B 1 81  ? 18.628  -50.702 38.041  1.00 64.28  ?  75  CYS B C   1 
ATOM   2786 O O   . CYS B 1 81  ? 18.910  -51.830 38.458  1.00 62.15  ?  75  CYS B O   1 
ATOM   2787 C CB  . CYS B 1 81  ? 20.233  -49.705 39.709  1.00 55.21  ?  75  CYS B CB  1 
ATOM   2788 S SG  . CYS B 1 81  ? 20.820  -48.114 40.376  1.00 60.06  ?  75  CYS B SG  1 
ATOM   2789 N N   . THR B 1 82  ? 17.588  -50.471 37.268  1.00 61.08  ?  76  THR B N   1 
ATOM   2790 C CA  . THR B 1 82  ? 16.556  -51.343 36.743  1.00 61.56  ?  76  THR B CA  1 
ATOM   2791 C C   . THR B 1 82  ? 16.994  -51.959 35.412  1.00 64.41  ?  76  THR B C   1 
ATOM   2792 O O   . THR B 1 82  ? 17.830  -51.393 34.704  1.00 66.04  ?  76  THR B O   1 
ATOM   2793 C CB  . THR B 1 82  ? 15.271  -50.550 36.556  1.00 65.30  ?  76  THR B CB  1 
ATOM   2794 O OG1 . THR B 1 82  ? 15.537  -49.422 35.715  1.00 64.82  ?  76  THR B OG1 1 
ATOM   2795 C CG2 . THR B 1 82  ? 14.767  -50.048 37.906  1.00 56.68  ?  76  THR B CG2 1 
ATOM   2796 N N   . PRO B 1 83  ? 16.471  -53.134 35.056  1.00 68.74  ?  77  PRO B N   1 
ATOM   2797 C CA  . PRO B 1 83  ? 16.856  -53.765 33.783  1.00 64.80  ?  77  PRO B CA  1 
ATOM   2798 C C   . PRO B 1 83  ? 16.576  -52.870 32.584  1.00 67.07  ?  77  PRO B C   1 
ATOM   2799 O O   . PRO B 1 83  ? 15.636  -52.068 32.582  1.00 68.14  ?  77  PRO B O   1 
ATOM   2800 C CB  . PRO B 1 83  ? 15.984  -55.025 33.740  1.00 65.68  ?  77  PRO B CB  1 
ATOM   2801 C CG  . PRO B 1 83  ? 15.682  -55.318 35.156  1.00 64.93  ?  77  PRO B CG  1 
ATOM   2802 C CD  . PRO B 1 83  ? 15.571  -53.993 35.847  1.00 68.36  ?  77  PRO B CD  1 
ATOM   2803 N N   . THR B 1 84  ? 17.388  -53.052 31.540  1.00 65.41  ?  78  THR B N   1 
ATOM   2804 C CA  . THR B 1 84  ? 17.367  -52.159 30.382  1.00 68.63  ?  78  THR B CA  1 
ATOM   2805 C C   . THR B 1 84  ? 15.951  -51.911 29.874  1.00 72.78  ?  78  THR B C   1 
ATOM   2806 O O   . THR B 1 84  ? 15.482  -50.768 29.868  1.00 74.46  ?  78  THR B O   1 
ATOM   2807 C CB  . THR B 1 84  ? 18.250  -52.721 29.265  1.00 70.25  ?  78  THR B CB  1 
ATOM   2808 O OG1 . THR B 1 84  ? 19.626  -52.653 29.658  1.00 70.89  ?  78  THR B OG1 1 
ATOM   2809 C CG2 . THR B 1 84  ? 18.063  -51.914 27.988  1.00 77.44  ?  78  THR B CG2 1 
ATOM   2810 N N   . ARG B 1 85  ? 15.235  -52.980 29.491  1.00 74.45  ?  79  ARG B N   1 
ATOM   2811 C CA  . ARG B 1 85  ? 13.950  -52.827 28.807  1.00 70.83  ?  79  ARG B CA  1 
ATOM   2812 C C   . ARG B 1 85  ? 12.953  -52.044 29.640  1.00 72.86  ?  79  ARG B C   1 
ATOM   2813 O O   . ARG B 1 85  ? 12.095  -51.352 29.086  1.00 75.03  ?  79  ARG B O   1 
ATOM   2814 C CB  . ARG B 1 85  ? 13.353  -54.192 28.467  1.00 80.00  ?  79  ARG B CB  1 
ATOM   2815 C CG  . ARG B 1 85  ? 14.347  -55.239 27.991  1.00 86.25  ?  79  ARG B CG  1 
ATOM   2816 C CD  . ARG B 1 85  ? 15.230  -54.715 26.874  1.00 91.46  ?  79  ARG B CD  1 
ATOM   2817 N NE  . ARG B 1 85  ? 14.697  -55.043 25.556  1.00 99.13  ?  79  ARG B NE  1 
ATOM   2818 C CZ  . ARG B 1 85  ? 15.282  -55.868 24.700  1.00 99.56  ?  79  ARG B CZ  1 
ATOM   2819 N NH1 . ARG B 1 85  ? 16.420  -56.478 24.997  1.00 95.82  ?  79  ARG B NH1 1 
ATOM   2820 N NH2 . ARG B 1 85  ? 14.713  -56.085 23.517  1.00 103.82 ?  79  ARG B NH2 1 
ATOM   2821 N N   . GLU B 1 86  ? 13.042  -52.148 30.965  1.00 70.16  ?  80  GLU B N   1 
ATOM   2822 C CA  . GLU B 1 86  ? 12.095  -51.492 31.855  1.00 67.17  ?  80  GLU B CA  1 
ATOM   2823 C C   . GLU B 1 86  ? 12.458  -50.045 32.131  1.00 71.51  ?  80  GLU B C   1 
ATOM   2824 O O   . GLU B 1 86  ? 11.636  -49.306 32.693  1.00 71.91  ?  80  GLU B O   1 
ATOM   2825 C CB  . GLU B 1 86  ? 12.027  -52.247 33.190  1.00 71.34  ?  80  GLU B CB  1 
ATOM   2826 C CG  . GLU B 1 86  ? 10.926  -53.301 33.287  1.00 76.73  ?  80  GLU B CG  1 
ATOM   2827 C CD  . GLU B 1 86  ? 11.259  -54.589 32.545  1.00 79.72  ?  80  GLU B CD  1 
ATOM   2828 O OE1 . GLU B 1 86  ? 12.447  -54.975 32.479  1.00 81.21  ?  80  GLU B OE1 1 
ATOM   2829 O OE2 . GLU B 1 86  ? 10.322  -55.216 32.012  1.00 90.98  -1 80  GLU B OE2 1 
ATOM   2830 N N   . THR B 1 87  ? 13.666  -49.625 31.765  1.00 66.46  ?  81  THR B N   1 
ATOM   2831 C CA  . THR B 1 87  ? 14.203  -48.405 32.338  1.00 63.87  ?  81  THR B CA  1 
ATOM   2832 C C   . THR B 1 87  ? 13.627  -47.153 31.670  1.00 64.89  ?  81  THR B C   1 
ATOM   2833 O O   . THR B 1 87  ? 13.290  -46.188 32.380  1.00 65.37  ?  81  THR B O   1 
ATOM   2834 C CB  . THR B 1 87  ? 15.735  -48.450 32.278  1.00 68.89  ?  81  THR B CB  1 
ATOM   2835 O OG1 . THR B 1 87  ? 16.208  -49.445 33.201  1.00 63.85  ?  81  THR B OG1 1 
ATOM   2836 C CG2 . THR B 1 87  ? 16.355  -47.094 32.649  1.00 64.15  ?  81  THR B CG2 1 
ATOM   2837 N N   . PRO B 1 88  ? 13.463  -47.107 30.340  1.00 59.47  ?  82  PRO B N   1 
ATOM   2838 C CA  . PRO B 1 88  ? 12.826  -45.907 29.764  1.00 62.87  ?  82  PRO B CA  1 
ATOM   2839 C C   . PRO B 1 88  ? 11.463  -45.581 30.363  1.00 64.53  ?  82  PRO B C   1 
ATOM   2840 O O   . PRO B 1 88  ? 11.219  -44.412 30.702  1.00 68.08  ?  82  PRO B O   1 
ATOM   2841 C CB  . PRO B 1 88  ? 12.763  -46.239 28.271  1.00 62.81  ?  82  PRO B CB  1 
ATOM   2842 C CG  . PRO B 1 88  ? 13.998  -47.073 28.050  1.00 59.65  ?  82  PRO B CG  1 
ATOM   2843 C CD  . PRO B 1 88  ? 14.025  -47.966 29.279  1.00 63.29  ?  82  PRO B CD  1 
ATOM   2844 N N   . ALA B 1 89  ? 10.589  -46.579 30.568  1.00 65.84  ?  83  ALA B N   1 
ATOM   2845 C CA  . ALA B 1 89  ? 9.254   -46.294 31.102  1.00 67.40  ?  83  ALA B CA  1 
ATOM   2846 C C   . ALA B 1 89  ? 9.316   -45.810 32.547  1.00 62.02  ?  83  ALA B C   1 
ATOM   2847 O O   . ALA B 1 89  ? 8.532   -44.938 32.949  1.00 66.70  ?  83  ALA B O   1 
ATOM   2848 C CB  . ALA B 1 89  ? 8.359   -47.535 30.992  1.00 70.92  ?  83  ALA B CB  1 
ATOM   2849 N N   . ILE B 1 90  ? 10.231  -46.375 33.343  1.00 63.05  ?  84  ILE B N   1 
ATOM   2850 C CA  . ILE B 1 90  ? 10.442  -45.916 34.714  1.00 63.73  ?  84  ILE B CA  1 
ATOM   2851 C C   . ILE B 1 90  ? 10.989  -44.495 34.725  1.00 64.53  ?  84  ILE B C   1 
ATOM   2852 O O   . ILE B 1 90  ? 10.593  -43.662 35.556  1.00 62.90  ?  84  ILE B O   1 
ATOM   2853 C CB  . ILE B 1 90  ? 11.382  -46.887 35.452  1.00 67.26  ?  84  ILE B CB  1 
ATOM   2854 C CG1 . ILE B 1 90  ? 10.702  -48.234 35.671  1.00 58.84  ?  84  ILE B CG1 1 
ATOM   2855 C CG2 . ILE B 1 90  ? 11.881  -46.291 36.785  1.00 59.69  ?  84  ILE B CG2 1 
ATOM   2856 C CD1 . ILE B 1 90  ? 11.665  -49.311 36.054  1.00 62.19  ?  84  ILE B CD1 1 
ATOM   2857 N N   . ALA B 1 91  ? 11.913  -44.196 33.810  1.00 66.86  ?  85  ALA B N   1 
ATOM   2858 C CA  . ALA B 1 91  ? 12.449  -42.841 33.705  1.00 66.98  ?  85  ALA B CA  1 
ATOM   2859 C C   . ALA B 1 91  ? 11.339  -41.832 33.407  1.00 67.52  ?  85  ALA B C   1 
ATOM   2860 O O   . ALA B 1 91  ? 11.142  -40.853 34.149  1.00 65.36  ?  85  ALA B O   1 
ATOM   2861 C CB  . ALA B 1 91  ? 13.539  -42.796 32.630  1.00 63.01  ?  85  ALA B CB  1 
ATOM   2862 N N   . LYS B 1 92  ? 10.585  -42.064 32.327  1.00 66.93  ?  86  LYS B N   1 
ATOM   2863 C CA  . LYS B 1 92  ? 9.519   -41.128 31.973  1.00 65.87  ?  86  LYS B CA  1 
ATOM   2864 C C   . LYS B 1 92  ? 8.574   -40.888 33.143  1.00 64.30  ?  86  LYS B C   1 
ATOM   2865 O O   . LYS B 1 92  ? 8.149   -39.753 33.385  1.00 65.30  ?  86  LYS B O   1 
ATOM   2866 C CB  . LYS B 1 92  ? 8.745   -41.638 30.762  1.00 66.79  ?  86  LYS B CB  1 
ATOM   2867 C CG  . LYS B 1 92  ? 9.580   -41.736 29.513  1.00 64.87  ?  86  LYS B CG  1 
ATOM   2868 C CD  . LYS B 1 92  ? 8.852   -42.524 28.467  1.00 66.59  ?  86  LYS B CD  1 
ATOM   2869 C CE  . LYS B 1 92  ? 9.778   -42.909 27.343  1.00 69.88  ?  86  LYS B CE  1 
ATOM   2870 N NZ  . LYS B 1 92  ? 9.014   -43.490 26.201  1.00 80.90  ?  86  LYS B NZ  1 
ATOM   2871 N N   . GLU B 1 93  ? 8.254   -41.936 33.901  1.00 65.07  ?  87  GLU B N   1 
ATOM   2872 C CA  . GLU B 1 93  ? 7.366   -41.748 35.042  1.00 64.90  ?  87  GLU B CA  1 
ATOM   2873 C C   . GLU B 1 93  ? 7.964   -40.789 36.069  1.00 65.24  ?  87  GLU B C   1 
ATOM   2874 O O   . GLU B 1 93  ? 7.256   -39.936 36.622  1.00 67.22  ?  87  GLU B O   1 
ATOM   2875 C CB  . GLU B 1 93  ? 7.062   -43.093 35.685  1.00 68.92  ?  87  GLU B CB  1 
ATOM   2876 C CG  . GLU B 1 93  ? 6.598   -42.961 37.096  1.00 68.53  ?  87  GLU B CG  1 
ATOM   2877 C CD  . GLU B 1 93  ? 5.592   -44.010 37.447  1.00 85.89  ?  87  GLU B CD  1 
ATOM   2878 O OE1 . GLU B 1 93  ? 5.192   -44.769 36.530  1.00 81.29  ?  87  GLU B OE1 1 
ATOM   2879 O OE2 . GLU B 1 93  ? 5.204   -44.068 38.638  1.00 95.63  -1 87  GLU B OE2 1 
ATOM   2880 N N   . LEU B 1 94  ? 9.270   -40.905 36.334  1.00 62.73  ?  88  LEU B N   1 
ATOM   2881 C CA  . LEU B 1 94  ? 9.890   -40.046 37.339  1.00 60.65  ?  88  LEU B CA  1 
ATOM   2882 C C   . LEU B 1 94  ? 10.124  -38.633 36.812  1.00 62.27  ?  88  LEU B C   1 
ATOM   2883 O O   . LEU B 1 94  ? 9.947   -37.650 37.549  1.00 56.20  ?  88  LEU B O   1 
ATOM   2884 C CB  . LEU B 1 94  ? 11.200  -40.665 37.818  1.00 63.84  ?  88  LEU B CB  1 
ATOM   2885 C CG  . LEU B 1 94  ? 11.012  -41.944 38.639  1.00 63.55  ?  88  LEU B CG  1 
ATOM   2886 C CD1 . LEU B 1 94  ? 12.196  -42.871 38.496  1.00 61.24  ?  88  LEU B CD1 1 
ATOM   2887 C CD2 . LEU B 1 94  ? 10.771  -41.603 40.092  1.00 60.32  ?  88  LEU B CD2 1 
ATOM   2888 N N   . LEU B 1 95  ? 10.519  -38.504 35.543  1.00 62.08  ?  89  LEU B N   1 
ATOM   2889 C CA  . LEU B 1 95  ? 10.672  -37.166 34.973  1.00 62.79  ?  89  LEU B CA  1 
ATOM   2890 C C   . LEU B 1 95  ? 9.345   -36.408 35.010  1.00 65.08  ?  89  LEU B C   1 
ATOM   2891 O O   . LEU B 1 95  ? 9.305   -35.208 35.333  1.00 63.81  ?  89  LEU B O   1 
ATOM   2892 C CB  . LEU B 1 95  ? 11.220  -37.259 33.543  1.00 62.76  ?  89  LEU B CB  1 
ATOM   2893 C CG  . LEU B 1 95  ? 12.640  -37.816 33.330  1.00 58.38  ?  89  LEU B CG  1 
ATOM   2894 C CD1 . LEU B 1 95  ? 12.774  -38.380 31.925  1.00 56.75  ?  89  LEU B CD1 1 
ATOM   2895 C CD2 . LEU B 1 95  ? 13.727  -36.754 33.550  1.00 56.39  ?  89  LEU B CD2 1 
ATOM   2896 N N   . ALA B 1 96  ? 8.239   -37.112 34.733  1.00 65.06  ?  90  ALA B N   1 
ATOM   2897 C CA  . ALA B 1 96  ? 6.922   -36.487 34.719  1.00 59.89  ?  90  ALA B CA  1 
ATOM   2898 C C   . ALA B 1 96  ? 6.576   -35.821 36.036  1.00 57.01  ?  90  ALA B C   1 
ATOM   2899 O O   . ALA B 1 96  ? 5.729   -34.925 36.045  1.00 63.83  ?  90  ALA B O   1 
ATOM   2900 C CB  . ALA B 1 96  ? 5.856   -37.519 34.357  1.00 61.49  ?  90  ALA B CB  1 
ATOM   2901 N N   . ARG B 1 97  ? 7.193   -36.231 37.141  1.00 56.83  ?  91  ARG B N   1 
ATOM   2902 C CA  . ARG B 1 97  ? 7.047   -35.555 38.426  1.00 53.20  ?  91  ARG B CA  1 
ATOM   2903 C C   . ARG B 1 97  ? 8.119   -34.504 38.672  1.00 60.40  ?  91  ARG B C   1 
ATOM   2904 O O   . ARG B 1 97  ? 8.181   -33.945 39.777  1.00 60.13  ?  91  ARG B O   1 
ATOM   2905 C CB  . ARG B 1 97  ? 7.110   -36.553 39.567  1.00 60.52  ?  91  ARG B CB  1 
ATOM   2906 C CG  . ARG B 1 97  ? 6.111   -37.671 39.500  1.00 68.88  ?  91  ARG B CG  1 
ATOM   2907 C CD  . ARG B 1 97  ? 5.945   -38.202 40.898  1.00 72.02  ?  91  ARG B CD  1 
ATOM   2908 N NE  . ARG B 1 97  ? 6.049   -39.651 40.960  1.00 77.42  ?  91  ARG B NE  1 
ATOM   2909 C CZ  . ARG B 1 97  ? 5.731   -40.358 42.033  1.00 79.06  ?  91  ARG B CZ  1 
ATOM   2910 N NH1 . ARG B 1 97  ? 5.367   -39.765 43.160  1.00 85.35  ?  91  ARG B NH1 1 
ATOM   2911 N NH2 . ARG B 1 97  ? 5.783   -41.688 41.978  1.00 75.98  ?  91  ARG B NH2 1 
ATOM   2912 N N   . GLY B 1 98  ? 8.985   -34.233 37.698  1.00 59.29  ?  92  GLY B N   1 
ATOM   2913 C CA  . GLY B 1 98  ? 10.006  -33.234 37.923  1.00 56.38  ?  92  GLY B CA  1 
ATOM   2914 C C   . GLY B 1 98  ? 11.195  -33.690 38.741  1.00 58.80  ?  92  GLY B C   1 
ATOM   2915 O O   . GLY B 1 98  ? 11.924  -32.848 39.276  1.00 65.37  ?  92  GLY B O   1 
ATOM   2916 N N   . ILE B 1 99  ? 11.407  -34.993 38.859  1.00 55.37  ?  93  ILE B N   1 
ATOM   2917 C CA  . ILE B 1 99  ? 12.609  -35.569 39.441  1.00 57.89  ?  93  ILE B CA  1 
ATOM   2918 C C   . ILE B 1 99  ? 13.558  -35.908 38.300  1.00 60.30  ?  93  ILE B C   1 
ATOM   2919 O O   . ILE B 1 99  ? 13.141  -36.506 37.291  1.00 57.43  ?  93  ILE B O   1 
ATOM   2920 C CB  . ILE B 1 99  ? 12.269  -36.828 40.254  1.00 62.91  ?  93  ILE B CB  1 
ATOM   2921 C CG1 . ILE B 1 99  ? 11.244  -36.506 41.338  1.00 60.15  ?  93  ILE B CG1 1 
ATOM   2922 C CG2 . ILE B 1 99  ? 13.527  -37.502 40.818  1.00 59.22  ?  93  ILE B CG2 1 
ATOM   2923 C CD1 . ILE B 1 99  ? 10.655  -37.754 41.930  1.00 60.47  ?  93  ILE B CD1 1 
ATOM   2924 N N   . HIS B 1 100 ? 14.830  -35.536 38.452  1.00 53.80  ?  94  HIS B N   1 
ATOM   2925 C CA  . HIS B 1 100 ? 15.825  -35.877 37.445  1.00 56.37  ?  94  HIS B CA  1 
ATOM   2926 C C   . HIS B 1 100 ? 16.161  -37.370 37.509  1.00 56.34  ?  94  HIS B C   1 
ATOM   2927 O O   . HIS B 1 100 ? 15.998  -38.023 38.544  1.00 54.63  ?  94  HIS B O   1 
ATOM   2928 C CB  . HIS B 1 100 ? 17.100  -35.045 37.633  1.00 60.88  ?  94  HIS B CB  1 
ATOM   2929 C CG  . HIS B 1 100 ? 16.851  -33.589 37.858  1.00 57.51  ?  94  HIS B CG  1 
ATOM   2930 N ND1 . HIS B 1 100 ? 15.898  -32.878 37.158  1.00 63.32  ?  94  HIS B ND1 1 
ATOM   2931 C CD2 . HIS B 1 100 ? 17.445  -32.703 38.692  1.00 58.10  ?  94  HIS B CD2 1 
ATOM   2932 C CE1 . HIS B 1 100 ? 15.903  -31.621 37.560  1.00 55.59  ?  94  HIS B CE1 1 
ATOM   2933 N NE2 . HIS B 1 100 ? 16.828  -31.489 38.495  1.00 64.69  ?  94  HIS B NE2 1 
ATOM   2934 N N   . THR B 1 101 ? 16.617  -37.921 36.384  1.00 53.86  ?  95  THR B N   1 
ATOM   2935 C CA  . THR B 1 101 ? 16.861  -39.355 36.312  1.00 57.60  ?  95  THR B CA  1 
ATOM   2936 C C   . THR B 1 101 ? 18.225  -39.617 35.684  1.00 58.73  ?  95  THR B C   1 
ATOM   2937 O O   . THR B 1 101 ? 18.666  -38.889 34.784  1.00 60.71  ?  95  THR B O   1 
ATOM   2938 C CB  . THR B 1 101 ? 15.727  -40.122 35.530  1.00 58.84  ?  95  THR B CB  1 
ATOM   2939 O OG1 . THR B 1 101 ? 15.563  -39.606 34.205  1.00 59.83  ?  95  THR B OG1 1 
ATOM   2940 C CG2 . THR B 1 101 ? 14.404  -40.001 36.235  1.00 56.78  ?  95  THR B CG2 1 
ATOM   2941 N N   . ILE B 1 102 ? 18.899  -40.642 36.199  1.00 56.01  ?  96  ILE B N   1 
ATOM   2942 C CA  . ILE B 1 102 ? 20.157  -41.147 35.664  1.00 54.29  ?  96  ILE B CA  1 
ATOM   2943 C C   . ILE B 1 102 ? 19.953  -42.607 35.302  1.00 56.69  ?  96  ILE B C   1 
ATOM   2944 O O   . ILE B 1 102 ? 19.417  -43.379 36.103  1.00 57.35  ?  96  ILE B O   1 
ATOM   2945 C CB  . ILE B 1 102 ? 21.307  -41.021 36.677  1.00 55.30  ?  96  ILE B CB  1 
ATOM   2946 C CG1 . ILE B 1 102 ? 21.329  -39.612 37.300  1.00 57.55  ?  96  ILE B CG1 1 
ATOM   2947 C CG2 . ILE B 1 102 ? 22.625  -41.444 36.013  1.00 51.15  ?  96  ILE B CG2 1 
ATOM   2948 C CD1 . ILE B 1 102 ? 21.859  -38.522 36.403  1.00 52.43  ?  96  ILE B CD1 1 
ATOM   2949 N N   . ASP B 1 103 ? 20.381  -42.994 34.109  1.00 53.33  ?  97  ASP B N   1 
ATOM   2950 C CA  . ASP B 1 103 ? 20.403  -44.404 33.776  1.00 56.67  ?  97  ASP B CA  1 
ATOM   2951 C C   . ASP B 1 103 ? 21.682  -44.714 33.014  1.00 62.34  ?  97  ASP B C   1 
ATOM   2952 O O   . ASP B 1 103 ? 22.397  -43.817 32.547  1.00 63.26  ?  97  ASP B O   1 
ATOM   2953 C CB  . ASP B 1 103 ? 19.174  -44.817 32.973  1.00 58.05  ?  97  ASP B CB  1 
ATOM   2954 C CG  . ASP B 1 103 ? 19.140  -44.196 31.595  1.00 64.77  ?  97  ASP B CG  1 
ATOM   2955 O OD1 . ASP B 1 103 ? 20.082  -44.424 30.799  1.00 67.27  ?  97  ASP B OD1 1 
ATOM   2956 O OD2 . ASP B 1 103 ? 18.151  -43.490 31.293  1.00 66.33  -1 97  ASP B OD2 1 
ATOM   2957 N N   . SER B 1 104 ? 21.965  -46.001 32.895  1.00 56.86  ?  98  SER B N   1 
ATOM   2958 C CA  . SER B 1 104 ? 23.029  -46.468 32.026  1.00 58.56  ?  98  SER B CA  1 
ATOM   2959 C C   . SER B 1 104 ? 22.490  -47.515 31.059  1.00 61.29  ?  98  SER B C   1 
ATOM   2960 O O   . SER B 1 104 ? 23.189  -48.477 30.720  1.00 64.25  ?  98  SER B O   1 
ATOM   2961 C CB  . SER B 1 104 ? 24.205  -47.014 32.836  1.00 58.23  ?  98  SER B CB  1 
ATOM   2962 O OG  . SER B 1 104 ? 23.842  -48.196 33.523  1.00 59.22  ?  98  SER B OG  1 
ATOM   2963 N N   . PHE B 1 105 ? 21.224  -47.359 30.666  1.00 57.13  ?  99  PHE B N   1 
ATOM   2964 C CA  . PHE B 1 105 ? 20.635  -47.953 29.473  1.00 60.41  ?  99  PHE B CA  1 
ATOM   2965 C C   . PHE B 1 105 ? 21.694  -48.269 28.423  1.00 68.27  ?  99  PHE B C   1 
ATOM   2966 O O   . PHE B 1 105 ? 22.467  -47.378 28.035  1.00 68.77  ?  99  PHE B O   1 
ATOM   2967 C CB  . PHE B 1 105 ? 19.599  -46.983 28.916  1.00 64.18  ?  99  PHE B CB  1 
ATOM   2968 C CG  . PHE B 1 105 ? 18.886  -47.473 27.687  1.00 73.55  ?  99  PHE B CG  1 
ATOM   2969 C CD1 . PHE B 1 105 ? 19.421  -47.258 26.419  1.00 72.30  ?  99  PHE B CD1 1 
ATOM   2970 C CD2 . PHE B 1 105 ? 17.645  -48.108 27.793  1.00 67.69  ?  99  PHE B CD2 1 
ATOM   2971 C CE1 . PHE B 1 105 ? 18.743  -47.694 25.276  1.00 75.09  ?  99  PHE B CE1 1 
ATOM   2972 C CE2 . PHE B 1 105 ? 16.969  -48.542 26.658  1.00 71.45  ?  99  PHE B CE2 1 
ATOM   2973 C CZ  . PHE B 1 105 ? 17.520  -48.341 25.398  1.00 71.34  ?  99  PHE B CZ  1 
ATOM   2974 N N   . ASP B 1 106 ? 21.747  -49.523 27.943  1.00 68.47  ?  100 ASP B N   1 
ATOM   2975 C CA  . ASP B 1 106 ? 22.902  -49.971 27.168  1.00 65.53  ?  100 ASP B CA  1 
ATOM   2976 C C   . ASP B 1 106 ? 22.546  -50.662 25.850  1.00 69.31  ?  100 ASP B C   1 
ATOM   2977 O O   . ASP B 1 106 ? 23.315  -51.491 25.362  1.00 76.48  ?  100 ASP B O   1 
ATOM   2978 C CB  . ASP B 1 106 ? 23.784  -50.885 28.017  1.00 73.57  ?  100 ASP B CB  1 
ATOM   2979 C CG  . ASP B 1 106 ? 23.097  -52.174 28.409  1.00 73.43  ?  100 ASP B CG  1 
ATOM   2980 O OD1 . ASP B 1 106 ? 21.902  -52.357 28.077  1.00 71.37  ?  100 ASP B OD1 1 
ATOM   2981 O OD2 . ASP B 1 106 ? 23.772  -53.000 29.064  1.00 76.40  -1 100 ASP B OD2 1 
ATOM   2982 N N   . ILE B 1 107 ? 21.418  -50.330 25.238  1.00 75.44  ?  101 ILE B N   1 
ATOM   2983 C CA  . ILE B 1 107 ? 21.094  -50.804 23.894  1.00 78.44  ?  101 ILE B CA  1 
ATOM   2984 C C   . ILE B 1 107 ? 21.547  -49.684 22.954  1.00 76.55  ?  101 ILE B C   1 
ATOM   2985 O O   . ILE B 1 107 ? 20.840  -48.686 22.779  1.00 76.30  ?  101 ILE B O   1 
ATOM   2986 C CB  . ILE B 1 107 ? 19.597  -51.129 23.749  1.00 81.96  ?  101 ILE B CB  1 
ATOM   2987 C CG1 . ILE B 1 107 ? 19.204  -52.378 24.558  1.00 77.34  ?  101 ILE B CG1 1 
ATOM   2988 C CG2 . ILE B 1 107 ? 19.232  -51.411 22.304  1.00 81.49  ?  101 ILE B CG2 1 
ATOM   2989 C CD1 . ILE B 1 107 ? 20.239  -53.507 24.507  1.00 82.49  ?  101 ILE B CD1 1 
ATOM   2990 N N   . HIS B 1 108 ? 22.745  -49.821 22.372  1.00 71.44  ?  102 HIS B N   1 
ATOM   2991 C CA  . HIS B 1 108 ? 23.346  -48.718 21.616  1.00 75.18  ?  102 HIS B CA  1 
ATOM   2992 C C   . HIS B 1 108 ? 22.410  -48.209 20.523  1.00 81.57  ?  102 HIS B C   1 
ATOM   2993 O O   . HIS B 1 108 ? 22.087  -47.015 20.462  1.00 75.93  ?  102 HIS B O   1 
ATOM   2994 C CB  . HIS B 1 108 ? 24.679  -49.159 21.009  1.00 71.08  ?  102 HIS B CB  1 
ATOM   2995 C CG  . HIS B 1 108 ? 25.794  -49.263 22.005  1.00 71.31  ?  102 HIS B CG  1 
ATOM   2996 N ND1 . HIS B 1 108 ? 26.798  -48.323 22.103  1.00 73.10  ?  102 HIS B ND1 1 
ATOM   2997 C CD2 . HIS B 1 108 ? 26.061  -50.193 22.952  1.00 75.56  ?  102 HIS B CD2 1 
ATOM   2998 C CE1 . HIS B 1 108 ? 27.637  -48.672 23.063  1.00 73.43  ?  102 HIS B CE1 1 
ATOM   2999 N NE2 . HIS B 1 108 ? 27.216  -49.806 23.590  1.00 75.55  ?  102 HIS B NE2 1 
ATOM   3000 N N   . GLN B 1 109 ? 21.930  -49.120 19.677  1.00 82.71  ?  103 GLN B N   1 
ATOM   3001 C CA  . GLN B 1 109 ? 21.065  -48.816 18.544  1.00 76.27  ?  103 GLN B CA  1 
ATOM   3002 C C   . GLN B 1 109 ? 19.797  -48.064 18.935  1.00 77.05  ?  103 GLN B C   1 
ATOM   3003 O O   . GLN B 1 109 ? 19.112  -47.541 18.047  1.00 81.62  ?  103 GLN B O   1 
ATOM   3004 C CB  . GLN B 1 109 ? 20.713  -50.131 17.826  1.00 81.18  ?  103 GLN B CB  1 
ATOM   3005 C CG  . GLN B 1 109 ? 21.886  -51.159 17.701  1.00 84.03  ?  103 GLN B CG  1 
ATOM   3006 C CD  . GLN B 1 109 ? 22.333  -51.815 19.041  1.00 89.06  ?  103 GLN B CD  1 
ATOM   3007 O OE1 . GLN B 1 109 ? 21.539  -51.974 19.977  1.00 91.83  ?  103 GLN B OE1 1 
ATOM   3008 N NE2 . GLN B 1 109 ? 23.613  -52.173 19.127  1.00 87.20  ?  103 GLN B NE2 1 
ATOM   3009 N N   . GLU B 1 110 ? 19.485  -47.961 20.227  1.00 75.33  ?  104 GLU B N   1 
ATOM   3010 C CA  . GLU B 1 110 ? 18.234  -47.371 20.691  1.00 75.93  ?  104 GLU B CA  1 
ATOM   3011 C C   . GLU B 1 110 ? 18.398  -46.032 21.409  1.00 72.01  ?  104 GLU B C   1 
ATOM   3012 O O   . GLU B 1 110 ? 17.391  -45.428 21.812  1.00 71.23  ?  104 GLU B O   1 
ATOM   3013 C CB  . GLU B 1 110 ? 17.517  -48.358 21.622  1.00 81.55  ?  104 GLU B CB  1 
ATOM   3014 C CG  . GLU B 1 110 ? 16.716  -49.416 20.899  1.00 85.53  ?  104 GLU B CG  1 
ATOM   3015 C CD  . GLU B 1 110 ? 15.392  -48.875 20.402  1.00 92.81  ?  104 GLU B CD  1 
ATOM   3016 O OE1 . GLU B 1 110 ? 15.373  -48.252 19.311  1.00 92.55  ?  104 GLU B OE1 1 
ATOM   3017 O OE2 . GLU B 1 110 ? 14.373  -49.077 21.097  1.00 100.21 -1 104 GLU B OE2 1 
ATOM   3018 N N   . ILE B 1 111 ? 19.628  -45.544 21.573  1.00 70.50  ?  105 ILE B N   1 
ATOM   3019 C CA  . ILE B 1 111 ? 19.861  -44.399 22.449  1.00 68.12  ?  105 ILE B CA  1 
ATOM   3020 C C   . ILE B 1 111 ? 19.293  -43.124 21.834  1.00 68.95  ?  105 ILE B C   1 
ATOM   3021 O O   . ILE B 1 111 ? 18.624  -42.330 22.510  1.00 71.50  ?  105 ILE B O   1 
ATOM   3022 C CB  . ILE B 1 111 ? 21.365  -44.267 22.753  1.00 68.10  ?  105 ILE B CB  1 
ATOM   3023 C CG1 . ILE B 1 111 ? 21.776  -45.315 23.783  1.00 61.11  ?  105 ILE B CG1 1 
ATOM   3024 C CG2 . ILE B 1 111 ? 21.698  -42.850 23.227  1.00 65.52  ?  105 ILE B CG2 1 
ATOM   3025 C CD1 . ILE B 1 111 ? 23.241  -45.631 23.775  1.00 72.70  ?  105 ILE B CD1 1 
ATOM   3026 N N   . VAL B 1 112 ? 19.550  -42.902 20.544  1.00 64.67  ?  106 VAL B N   1 
ATOM   3027 C CA  . VAL B 1 112 ? 18.972  -41.736 19.889  1.00 62.32  ?  106 VAL B CA  1 
ATOM   3028 C C   . VAL B 1 112 ? 17.471  -41.698 20.118  1.00 64.80  ?  106 VAL B C   1 
ATOM   3029 O O   . VAL B 1 112 ? 16.906  -40.642 20.445  1.00 68.03  ?  106 VAL B O   1 
ATOM   3030 C CB  . VAL B 1 112 ? 19.323  -41.727 18.389  1.00 65.14  ?  106 VAL B CB  1 
ATOM   3031 C CG1 . VAL B 1 112 ? 18.490  -40.687 17.664  1.00 61.49  ?  106 VAL B CG1 1 
ATOM   3032 C CG2 . VAL B 1 112 ? 20.803  -41.449 18.201  1.00 68.59  ?  106 VAL B CG2 1 
ATOM   3033 N N   . GLN B 1 113 ? 16.803  -42.858 19.992  1.00 69.88  ?  107 GLN B N   1 
ATOM   3034 C CA  . GLN B 1 113 ? 15.346  -42.890 20.152  1.00 72.51  ?  107 GLN B CA  1 
ATOM   3035 C C   . GLN B 1 113 ? 14.943  -42.634 21.600  1.00 69.36  ?  107 GLN B C   1 
ATOM   3036 O O   . GLN B 1 113 ? 14.105  -41.761 21.874  1.00 67.31  ?  107 GLN B O   1 
ATOM   3037 C CB  . GLN B 1 113 ? 14.769  -44.224 19.664  1.00 75.08  ?  107 GLN B CB  1 
ATOM   3038 C CG  . GLN B 1 113 ? 13.218  -44.279 19.654  1.00 71.90  ?  107 GLN B CG  1 
ATOM   3039 C CD  . GLN B 1 113 ? 12.560  -43.088 18.939  1.00 76.04  ?  107 GLN B CD  1 
ATOM   3040 O OE1 . GLN B 1 113 ? 12.992  -42.683 17.863  1.00 81.24  ?  107 GLN B OE1 1 
ATOM   3041 N NE2 . GLN B 1 113 ? 11.506  -42.535 19.537  1.00 71.85  ?  107 GLN B NE2 1 
ATOM   3042 N N   . VAL B 1 114 ? 15.527  -43.384 22.543  1.00 64.55  ?  108 VAL B N   1 
ATOM   3043 C CA  . VAL B 1 114 ? 15.210  -43.164 23.951  1.00 65.65  ?  108 VAL B CA  1 
ATOM   3044 C C   . VAL B 1 114 ? 15.451  -41.713 24.320  1.00 66.63  ?  108 VAL B C   1 
ATOM   3045 O O   . VAL B 1 114 ? 14.624  -41.075 24.996  1.00 64.19  ?  108 VAL B O   1 
ATOM   3046 C CB  . VAL B 1 114 ? 16.040  -44.094 24.848  1.00 69.41  ?  108 VAL B CB  1 
ATOM   3047 C CG1 . VAL B 1 114 ? 15.750  -43.785 26.302  1.00 67.04  ?  108 VAL B CG1 1 
ATOM   3048 C CG2 . VAL B 1 114 ? 15.756  -45.524 24.523  1.00 67.31  ?  108 VAL B CG2 1 
ATOM   3049 N N   . ARG B 1 115 ? 16.583  -41.169 23.859  1.00 63.51  ?  109 ARG B N   1 
ATOM   3050 C CA  . ARG B 1 115 ? 16.940  -39.789 24.160  1.00 62.12  ?  109 ARG B CA  1 
ATOM   3051 C C   . ARG B 1 115 ? 15.841  -38.826 23.711  1.00 61.96  ?  109 ARG B C   1 
ATOM   3052 O O   . ARG B 1 115 ? 15.433  -37.945 24.475  1.00 63.46  ?  109 ARG B O   1 
ATOM   3053 C CB  . ARG B 1 115 ? 18.294  -39.457 23.519  1.00 61.41  ?  109 ARG B CB  1 
ATOM   3054 C CG  . ARG B 1 115 ? 18.884  -38.075 23.837  1.00 65.57  ?  109 ARG B CG  1 
ATOM   3055 C CD  . ARG B 1 115 ? 20.052  -37.750 22.879  1.00 70.04  ?  109 ARG B CD  1 
ATOM   3056 N NE  . ARG B 1 115 ? 20.414  -36.336 22.789  1.00 72.35  ?  109 ARG B NE  1 
ATOM   3057 C CZ  . ARG B 1 115 ? 19.617  -35.369 22.336  1.00 79.62  ?  109 ARG B CZ  1 
ATOM   3058 N NH1 . ARG B 1 115 ? 18.374  -35.618 21.940  1.00 72.81  ?  109 ARG B NH1 1 
ATOM   3059 N NH2 . ARG B 1 115 ? 20.073  -34.116 22.286  1.00 70.85  ?  109 ARG B NH2 1 
ATOM   3060 N N   . HIS B 1 116 ? 15.320  -38.990 22.488  1.00 62.73  ?  110 HIS B N   1 
ATOM   3061 C CA  . HIS B 1 116 ? 14.215  -38.119 22.068  1.00 65.69  ?  110 HIS B CA  1 
ATOM   3062 C C   . HIS B 1 116 ? 12.995  -38.288 22.976  1.00 62.76  ?  110 HIS B C   1 
ATOM   3063 O O   . HIS B 1 116 ? 12.424  -37.302 23.450  1.00 65.02  ?  110 HIS B O   1 
ATOM   3064 C CB  . HIS B 1 116 ? 13.845  -38.359 20.602  1.00 68.34  ?  110 HIS B CB  1 
ATOM   3065 C CG  . HIS B 1 116 ? 14.673  -37.567 19.631  1.00 73.41  ?  110 HIS B CG  1 
ATOM   3066 N ND1 . HIS B 1 116 ? 15.222  -36.337 19.942  1.00 74.87  ?  110 HIS B ND1 1 
ATOM   3067 C CD2 . HIS B 1 116 ? 15.055  -37.834 18.356  1.00 79.10  ?  110 HIS B CD2 1 
ATOM   3068 C CE1 . HIS B 1 116 ? 15.904  -35.882 18.902  1.00 74.76  ?  110 HIS B CE1 1 
ATOM   3069 N NE2 . HIS B 1 116 ? 15.821  -36.772 17.927  1.00 74.88  ?  110 HIS B NE2 1 
ATOM   3070 N N   . GLU B 1 117 ? 12.608  -39.532 23.276  1.00 64.53  ?  111 GLU B N   1 
ATOM   3071 C CA  . GLU B 1 117 ? 11.477  -39.752 24.176  1.00 63.65  ?  111 GLU B CA  1 
ATOM   3072 C C   . GLU B 1 117 ? 11.726  -39.109 25.539  1.00 61.73  ?  111 GLU B C   1 
ATOM   3073 O O   . GLU B 1 117 ? 10.978  -38.232 25.969  1.00 61.21  ?  111 GLU B O   1 
ATOM   3074 C CB  . GLU B 1 117 ? 11.202  -41.249 24.317  1.00 68.89  ?  111 GLU B CB  1 
ATOM   3075 C CG  . GLU B 1 117 ? 10.793  -41.948 23.023  1.00 68.58  ?  111 GLU B CG  1 
ATOM   3076 C CD  . GLU B 1 117 ? 10.653  -43.464 23.206  1.00 85.06  ?  111 GLU B CD  1 
ATOM   3077 O OE1 . GLU B 1 117 ? 10.165  -43.890 24.280  1.00 84.04  ?  111 GLU B OE1 1 
ATOM   3078 O OE2 . GLU B 1 117 ? 11.039  -44.236 22.286  1.00 86.13  -1 111 GLU B OE2 1 
ATOM   3079 N N   . LEU B 1 118 ? 12.814  -39.498 26.214  1.00 71.12  ?  112 LEU B N   1 
ATOM   3080 C CA  . LEU B 1 118 ? 13.145  -38.890 27.510  1.00 67.22  ?  112 LEU B CA  1 
ATOM   3081 C C   . LEU B 1 118 ? 13.225  -37.366 27.442  1.00 59.81  ?  112 LEU B C   1 
ATOM   3082 O O   . LEU B 1 118 ? 12.869  -36.675 28.407  1.00 61.11  ?  112 LEU B O   1 
ATOM   3083 C CB  . LEU B 1 118 ? 14.472  -39.458 28.032  1.00 63.52  ?  112 LEU B CB  1 
ATOM   3084 C CG  . LEU B 1 118 ? 14.354  -40.474 29.176  1.00 62.43  ?  112 LEU B CG  1 
ATOM   3085 C CD1 . LEU B 1 118 ? 13.382  -41.599 28.829  1.00 59.19  ?  112 LEU B CD1 1 
ATOM   3086 C CD2 . LEU B 1 118 ? 15.705  -41.038 29.525  1.00 60.42  ?  112 LEU B CD2 1 
ATOM   3087 N N   . ASP B 1 119 ? 13.683  -36.823 26.313  1.00 59.34  ?  113 ASP B N   1 
ATOM   3088 C CA  . ASP B 1 119 ? 13.806  -35.374 26.181  1.00 61.12  ?  113 ASP B CA  1 
ATOM   3089 C C   . ASP B 1 119 ? 12.441  -34.685 26.277  1.00 65.69  ?  113 ASP B C   1 
ATOM   3090 O O   . ASP B 1 119 ? 12.309  -33.648 26.940  1.00 62.77  ?  113 ASP B O   1 
ATOM   3091 C CB  . ASP B 1 119 ? 14.506  -35.063 24.855  1.00 64.91  ?  113 ASP B CB  1 
ATOM   3092 C CG  . ASP B 1 119 ? 14.777  -33.570 24.637  1.00 68.44  ?  113 ASP B CG  1 
ATOM   3093 O OD1 . ASP B 1 119 ? 15.108  -32.830 25.599  1.00 64.47  ?  113 ASP B OD1 1 
ATOM   3094 O OD2 . ASP B 1 119 ? 14.680  -33.152 23.462  1.00 72.80  -1 113 ASP B OD2 1 
ATOM   3095 N N   . GLU B 1 120 ? 11.405  -35.270 25.647  1.00 65.61  ?  114 GLU B N   1 
ATOM   3096 C CA  . GLU B 1 120 ? 10.086  -34.635 25.603  1.00 65.25  ?  114 GLU B CA  1 
ATOM   3097 C C   . GLU B 1 120 ? 9.516   -34.449 26.997  1.00 62.32  ?  114 GLU B C   1 
ATOM   3098 O O   . GLU B 1 120 ? 8.993   -33.382 27.329  1.00 60.96  ?  114 GLU B O   1 
ATOM   3099 C CB  . GLU B 1 120 ? 9.110   -35.475 24.778  1.00 75.28  ?  114 GLU B CB  1 
ATOM   3100 C CG  . GLU B 1 120 ? 9.255   -35.349 23.275  1.00 82.06  ?  114 GLU B CG  1 
ATOM   3101 C CD  . GLU B 1 120 ? 8.578   -36.499 22.552  1.00 87.06  ?  114 GLU B CD  1 
ATOM   3102 O OE1 . GLU B 1 120 ? 7.478   -36.904 23.017  1.00 84.23  ?  114 GLU B OE1 1 
ATOM   3103 O OE2 . GLU B 1 120 ? 9.148   -36.994 21.542  1.00 82.74  -1 114 GLU B OE2 1 
ATOM   3104 N N   . VAL B 1 121 ? 9.583   -35.498 27.821  1.00 63.22  ?  115 VAL B N   1 
ATOM   3105 C CA  . VAL B 1 121 ? 9.036   -35.423 29.172  1.00 59.17  ?  115 VAL B CA  1 
ATOM   3106 C C   . VAL B 1 121 ? 9.858   -34.465 30.023  1.00 63.66  ?  115 VAL B C   1 
ATOM   3107 O O   . VAL B 1 121 ? 9.306   -33.625 30.748  1.00 65.29  ?  115 VAL B O   1 
ATOM   3108 C CB  . VAL B 1 121 ? 8.993   -36.828 29.797  1.00 61.90  ?  115 VAL B CB  1 
ATOM   3109 C CG1 . VAL B 1 121 ? 8.278   -36.789 31.123  1.00 60.21  ?  115 VAL B CG1 1 
ATOM   3110 C CG2 . VAL B 1 121 ? 8.380   -37.820 28.835  1.00 56.31  ?  115 VAL B CG2 1 
ATOM   3111 N N   . ALA B 1 122 ? 11.194  -34.599 29.965  1.00 63.32  ?  116 ALA B N   1 
ATOM   3112 C CA  . ALA B 1 122 ? 12.094  -33.746 30.745  1.00 65.73  ?  116 ALA B CA  1 
ATOM   3113 C C   . ALA B 1 122 ? 11.748  -32.269 30.590  1.00 61.26  ?  116 ALA B C   1 
ATOM   3114 O O   . ALA B 1 122 ? 11.656  -31.519 31.578  1.00 53.69  ?  116 ALA B O   1 
ATOM   3115 C CB  . ALA B 1 122 ? 13.539  -33.995 30.313  1.00 56.61  ?  116 ALA B CB  1 
ATOM   3116 N N   . ARG B 1 123 ? 11.551  -31.836 29.340  1.00 61.33  ?  117 ARG B N   1 
ATOM   3117 C CA  . ARG B 1 123 ? 11.301  -30.422 29.079  1.00 67.92  ?  117 ARG B CA  1 
ATOM   3118 C C   . ARG B 1 123 ? 9.919   -29.982 29.549  1.00 64.84  ?  117 ARG B C   1 
ATOM   3119 O O   . ARG B 1 123 ? 9.724   -28.795 29.816  1.00 60.91  ?  117 ARG B O   1 
ATOM   3120 C CB  . ARG B 1 123 ? 11.473  -30.137 27.589  1.00 66.26  ?  117 ARG B CB  1 
ATOM   3121 C CG  . ARG B 1 123 ? 12.783  -30.619 27.045  1.00 64.25  ?  117 ARG B CG  1 
ATOM   3122 C CD  . ARG B 1 123 ? 13.253  -29.799 25.893  1.00 64.83  ?  117 ARG B CD  1 
ATOM   3123 N NE  . ARG B 1 123 ? 13.295  -28.388 26.240  1.00 70.30  ?  117 ARG B NE  1 
ATOM   3124 C CZ  . ARG B 1 123 ? 13.279  -27.394 25.357  1.00 76.05  ?  117 ARG B CZ  1 
ATOM   3125 N NH1 . ARG B 1 123 ? 13.245  -27.625 24.052  1.00 68.89  ?  117 ARG B NH1 1 
ATOM   3126 N NH2 . ARG B 1 123 ? 13.305  -26.137 25.795  1.00 73.07  ?  117 ARG B NH2 1 
ATOM   3127 N N   . ALA B 1 124 ? 8.968   -30.914 29.675  1.00 64.18  ?  118 ALA B N   1 
ATOM   3128 C CA  . ALA B 1 124 ? 7.637   -30.578 30.167  1.00 61.11  ?  118 ALA B CA  1 
ATOM   3129 C C   . ALA B 1 124 ? 7.617   -30.304 31.665  1.00 65.74  ?  118 ALA B C   1 
ATOM   3130 O O   . ALA B 1 124 ? 6.750   -29.560 32.154  1.00 62.29  ?  118 ALA B O   1 
ATOM   3131 C CB  . ALA B 1 124 ? 6.669   -31.710 29.850  1.00 62.57  ?  118 ALA B CB  1 
ATOM   3132 N N   . HIS B 1 125 ? 8.537   -30.901 32.420  1.00 66.57  ?  119 HIS B N   1 
ATOM   3133 C CA  . HIS B 1 125 ? 8.433   -30.851 33.873  1.00 61.91  ?  119 HIS B CA  1 
ATOM   3134 C C   . HIS B 1 125 ? 9.687   -30.295 34.526  1.00 67.84  ?  119 HIS B C   1 
ATOM   3135 O O   . HIS B 1 125 ? 9.899   -30.515 35.730  1.00 62.65  ?  119 HIS B O   1 
ATOM   3136 C CB  . HIS B 1 125 ? 8.090   -32.232 34.410  1.00 61.52  ?  119 HIS B CB  1 
ATOM   3137 C CG  . HIS B 1 125 ? 6.810   -32.764 33.853  1.00 67.26  ?  119 HIS B CG  1 
ATOM   3138 N ND1 . HIS B 1 125 ? 6.770   -33.730 32.870  1.00 66.49  ?  119 HIS B ND1 1 
ATOM   3139 C CD2 . HIS B 1 125 ? 5.523   -32.418 34.100  1.00 64.26  ?  119 HIS B CD2 1 
ATOM   3140 C CE1 . HIS B 1 125 ? 5.510   -33.985 32.563  1.00 68.76  ?  119 HIS B CE1 1 
ATOM   3141 N NE2 . HIS B 1 125 ? 4.735   -33.196 33.288  1.00 69.05  ?  119 HIS B NE2 1 
ATOM   3142 N N   . GLN B 1 126 ? 10.487  -29.543 33.761  1.00 62.77  ?  120 GLN B N   1 
ATOM   3143 C CA  . GLN B 1 126 ? 11.688  -28.902 34.275  1.00 66.31  ?  120 GLN B CA  1 
ATOM   3144 C C   . GLN B 1 126 ? 12.585  -29.933 34.955  1.00 60.26  ?  120 GLN B C   1 
ATOM   3145 O O   . GLN B 1 126 ? 12.960  -29.797 36.120  1.00 59.50  ?  120 GLN B O   1 
ATOM   3146 C CB  . GLN B 1 126 ? 11.327  -27.756 35.223  1.00 64.22  ?  120 GLN B CB  1 
ATOM   3147 C CG  . GLN B 1 126 ? 11.058  -26.454 34.493  1.00 74.97  ?  120 GLN B CG  1 
ATOM   3148 C CD  . GLN B 1 126 ? 11.903  -25.320 35.007  1.00 74.74  ?  120 GLN B CD  1 
ATOM   3149 O OE1 . GLN B 1 126 ? 11.900  -25.011 36.201  1.00 79.44  ?  120 GLN B OE1 1 
ATOM   3150 N NE2 . GLN B 1 126 ? 12.669  -24.712 34.112  1.00 77.76  ?  120 GLN B NE2 1 
ATOM   3151 N N   . ALA B 1 127 ? 12.879  -31.003 34.217  1.00 63.04  ?  121 ALA B N   1 
ATOM   3152 C CA  . ALA B 1 127 ? 13.621  -32.153 34.717  1.00 60.56  ?  121 ALA B CA  1 
ATOM   3153 C C   . ALA B 1 127 ? 14.754  -32.479 33.754  1.00 60.02  ?  121 ALA B C   1 
ATOM   3154 O O   . ALA B 1 127 ? 14.663  -32.196 32.557  1.00 58.70  ?  121 ALA B O   1 
ATOM   3155 C CB  . ALA B 1 127 ? 12.711  -33.373 34.869  1.00 56.05  ?  121 ALA B CB  1 
ATOM   3156 N N   . VAL B 1 128 ? 15.820  -33.086 34.276  1.00 58.18  ?  122 VAL B N   1 
ATOM   3157 C CA  . VAL B 1 128 ? 16.960  -33.493 33.463  1.00 56.64  ?  122 VAL B CA  1 
ATOM   3158 C C   . VAL B 1 128 ? 17.022  -35.008 33.462  1.00 58.43  ?  122 VAL B C   1 
ATOM   3159 O O   . VAL B 1 128 ? 16.941  -35.640 34.522  1.00 61.14  ?  122 VAL B O   1 
ATOM   3160 C CB  . VAL B 1 128 ? 18.284  -32.900 33.983  1.00 60.16  ?  122 VAL B CB  1 
ATOM   3161 C CG1 . VAL B 1 128 ? 19.517  -33.465 33.191  1.00 51.48  ?  122 VAL B CG1 1 
ATOM   3162 C CG2 . VAL B 1 128 ? 18.250  -31.399 33.935  1.00 56.38  ?  122 VAL B CG2 1 
ATOM   3163 N N   . ALA B 1 129 ? 17.174  -35.591 32.283  1.00 56.64  ?  123 ALA B N   1 
ATOM   3164 C CA  . ALA B 1 129 ? 17.557  -36.988 32.168  1.00 52.96  ?  123 ALA B CA  1 
ATOM   3165 C C   . ALA B 1 129 ? 18.963  -37.042 31.608  1.00 54.08  ?  123 ALA B C   1 
ATOM   3166 O O   . ALA B 1 129 ? 19.254  -36.396 30.594  1.00 53.25  ?  123 ALA B O   1 
ATOM   3167 C CB  . ALA B 1 129 ? 16.607  -37.766 31.255  1.00 55.83  ?  123 ALA B CB  1 
ATOM   3168 N N   . ILE B 1 130 ? 19.836  -37.796 32.272  1.00 56.79  ?  124 ILE B N   1 
ATOM   3169 C CA  . ILE B 1 130 ? 21.098  -38.220 31.680  1.00 53.95  ?  124 ILE B CA  1 
ATOM   3170 C C   . ILE B 1 130 ? 20.997  -39.724 31.481  1.00 55.94  ?  124 ILE B C   1 
ATOM   3171 O O   . ILE B 1 130 ? 20.918  -40.481 32.456  1.00 59.52  ?  124 ILE B O   1 
ATOM   3172 C CB  . ILE B 1 130 ? 22.305  -37.847 32.548  1.00 55.88  ?  124 ILE B CB  1 
ATOM   3173 C CG1 . ILE B 1 130 ? 22.384  -36.336 32.744  1.00 53.35  ?  124 ILE B CG1 1 
ATOM   3174 C CG2 . ILE B 1 130 ? 23.581  -38.366 31.908  1.00 54.67  ?  124 ILE B CG2 1 
ATOM   3175 C CD1 . ILE B 1 130 ? 23.371  -35.909 33.821  1.00 54.59  ?  124 ILE B CD1 1 
ATOM   3176 N N   . LEU B 1 131 ? 20.984  -40.159 30.224  1.00 55.58  ?  125 LEU B N   1 
ATOM   3177 C CA  . LEU B 1 131 ? 20.848  -41.565 29.879  1.00 59.93  ?  125 LEU B CA  1 
ATOM   3178 C C   . LEU B 1 131 ? 22.164  -42.153 29.380  1.00 59.07  ?  125 LEU B C   1 
ATOM   3179 O O   . LEU B 1 131 ? 23.083  -41.435 28.959  1.00 54.02  ?  125 LEU B O   1 
ATOM   3180 C CB  . LEU B 1 131 ? 19.785  -41.765 28.796  1.00 65.26  ?  125 LEU B CB  1 
ATOM   3181 C CG  . LEU B 1 131 ? 20.201  -41.231 27.417  1.00 66.37  ?  125 LEU B CG  1 
ATOM   3182 C CD1 . LEU B 1 131 ? 19.697  -42.155 26.332  1.00 65.80  ?  125 LEU B CD1 1 
ATOM   3183 C CD2 . LEU B 1 131 ? 19.706  -39.817 27.175  1.00 56.55  ?  125 LEU B CD2 1 
ATOM   3184 N N   . ALA B 1 132 ? 22.220  -43.492 29.399  1.00 60.27  ?  126 ALA B N   1 
ATOM   3185 C CA  . ALA B 1 132 ? 23.334  -44.257 28.827  1.00 57.31  ?  126 ALA B CA  1 
ATOM   3186 C C   . ALA B 1 132 ? 24.651  -43.898 29.511  1.00 57.42  ?  126 ALA B C   1 
ATOM   3187 O O   . ALA B 1 132 ? 25.712  -43.844 28.883  1.00 56.10  ?  126 ALA B O   1 
ATOM   3188 C CB  . ALA B 1 132 ? 23.422  -44.055 27.312  1.00 55.36  ?  126 ALA B CB  1 
ATOM   3189 N N   . ALA B 1 133 ? 24.572  -43.659 30.813  1.00 54.90  ?  127 ALA B N   1 
ATOM   3190 C CA  . ALA B 1 133 ? 25.643  -43.063 31.584  1.00 54.62  ?  127 ALA B CA  1 
ATOM   3191 C C   . ALA B 1 133 ? 26.360  -44.136 32.403  1.00 59.54  ?  127 ALA B C   1 
ATOM   3192 O O   . ALA B 1 133 ? 26.320  -44.137 33.636  1.00 61.79  ?  127 ALA B O   1 
ATOM   3193 C CB  . ALA B 1 133 ? 25.057  -41.988 32.483  1.00 52.74  ?  127 ALA B CB  1 
ATOM   3194 N N   . GLY B 1 134 ? 27.036  -45.052 31.718  1.00 56.13  ?  128 GLY B N   1 
ATOM   3195 C CA  . GLY B 1 134 ? 27.709  -46.138 32.406  1.00 57.75  ?  128 GLY B CA  1 
ATOM   3196 C C   . GLY B 1 134 ? 29.175  -46.188 32.035  1.00 64.15  ?  128 GLY B C   1 
ATOM   3197 O O   . GLY B 1 134 ? 29.869  -45.156 32.083  1.00 62.82  ?  128 GLY B O   1 
ATOM   3198 N N   . THR B 1 135 ? 29.662  -47.376 31.663  1.00 62.14  ?  129 THR B N   1 
ATOM   3199 C CA  . THR B 1 135 ? 31.043  -47.488 31.218  1.00 64.65  ?  129 THR B CA  1 
ATOM   3200 C C   . THR B 1 135 ? 31.107  -47.576 29.697  1.00 67.36  ?  129 THR B C   1 
ATOM   3201 O O   . THR B 1 135 ? 31.728  -46.701 29.085  1.00 70.28  ?  129 THR B O   1 
ATOM   3202 C CB  . THR B 1 135 ? 31.760  -48.679 31.858  1.00 63.37  ?  129 THR B CB  1 
ATOM   3203 O OG1 . THR B 1 135 ? 31.054  -49.876 31.550  1.00 68.97  ?  129 THR B OG1 1 
ATOM   3204 C CG2 . THR B 1 135 ? 31.790  -48.518 33.350  1.00 61.27  ?  129 THR B CG2 1 
ATOM   3205 N N   . ASP B 1 136 ? 30.515  -48.604 29.045  1.00 68.00  ?  130 ASP B N   1 
ATOM   3206 C CA  . ASP B 1 136 ? 30.769  -48.438 27.618  1.00 71.19  ?  130 ASP B CA  1 
ATOM   3207 C C   . ASP B 1 136 ? 29.739  -47.474 27.062  1.00 79.18  ?  130 ASP B C   1 
ATOM   3208 O O   . ASP B 1 136 ? 30.134  -46.423 26.534  1.00 82.99  ?  130 ASP B O   1 
ATOM   3209 C CB  . ASP B 1 136 ? 30.809  -49.705 26.785  1.00 72.80  ?  130 ASP B CB  1 
ATOM   3210 C CG  . ASP B 1 136 ? 31.650  -49.508 25.525  1.00 78.78  ?  130 ASP B CG  1 
ATOM   3211 O OD1 . ASP B 1 136 ? 31.596  -48.405 24.962  1.00 68.18  ?  130 ASP B OD1 1 
ATOM   3212 O OD2 . ASP B 1 136 ? 32.395  -50.427 25.105  1.00 93.73  ?  130 ASP B OD2 1 
ATOM   3213 N N   . PRO B 1 137 ? 28.442  -47.724 27.171  1.00 75.04  ?  131 PRO B N   1 
ATOM   3214 C CA  . PRO B 1 137 ? 27.545  -46.562 27.079  1.00 67.43  ?  131 PRO B CA  1 
ATOM   3215 C C   . PRO B 1 137 ? 27.965  -45.690 28.258  1.00 65.62  ?  131 PRO B C   1 
ATOM   3216 O O   . PRO B 1 137 ? 27.732  -46.059 29.410  1.00 62.11  ?  131 PRO B O   1 
ATOM   3217 C CB  . PRO B 1 137 ? 26.137  -47.153 27.218  1.00 63.94  ?  131 PRO B CB  1 
ATOM   3218 C CG  . PRO B 1 137 ? 26.331  -48.621 26.958  1.00 70.27  ?  131 PRO B CG  1 
ATOM   3219 C CD  . PRO B 1 137 ? 27.712  -48.951 27.502  1.00 65.70  ?  131 PRO B CD  1 
ATOM   3220 N N   . GLY B 1 138 ? 28.708  -44.618 28.017  1.00 62.86  ?  132 GLY B N   1 
ATOM   3221 C CA  . GLY B 1 138 ? 29.119  -43.786 29.126  1.00 56.81  ?  132 GLY B CA  1 
ATOM   3222 C C   . GLY B 1 138 ? 30.506  -43.227 28.945  1.00 60.01  ?  132 GLY B C   1 
ATOM   3223 O O   . GLY B 1 138 ? 30.777  -42.539 27.949  1.00 57.01  ?  132 GLY B O   1 
ATOM   3224 N N   . THR B 1 139 ? 31.412  -43.527 29.882  1.00 56.41  ?  133 THR B N   1 
ATOM   3225 C CA  . THR B 1 139 ? 32.699  -42.841 29.834  1.00 56.80  ?  133 THR B CA  1 
ATOM   3226 C C   . THR B 1 139 ? 33.561  -43.336 28.679  1.00 55.83  ?  133 THR B C   1 
ATOM   3227 O O   . THR B 1 139 ? 34.367  -42.569 28.148  1.00 57.25  ?  133 THR B O   1 
ATOM   3228 C CB  . THR B 1 139 ? 33.427  -42.957 31.173  1.00 54.94  ?  133 THR B CB  1 
ATOM   3229 O OG1 . THR B 1 139 ? 33.144  -44.221 31.764  1.00 56.26  ?  133 THR B OG1 1 
ATOM   3230 C CG2 . THR B 1 139 ? 32.934  -41.878 32.137  1.00 60.34  ?  133 THR B CG2 1 
ATOM   3231 N N   . CYS B 1 140 ? 33.395  -44.585 28.244  1.00 56.01  ?  134 CYS B N   1 
ATOM   3232 C CA  . CYS B 1 140 ? 34.112  -45.017 27.049  1.00 56.81  ?  134 CYS B CA  1 
ATOM   3233 C C   . CYS B 1 140 ? 33.669  -44.203 25.836  1.00 57.99  ?  134 CYS B C   1 
ATOM   3234 O O   . CYS B 1 140 ? 34.497  -43.824 24.991  1.00 53.02  ?  134 CYS B O   1 
ATOM   3235 C CB  . CYS B 1 140 ? 33.916  -46.526 26.828  1.00 63.61  ?  134 CYS B CB  1 
ATOM   3236 S SG  . CYS B 1 140 ? 34.848  -47.621 27.991  1.00 61.27  ?  134 CYS B SG  1 
ATOM   3237 N N   . SER B 1 141 ? 32.365  -43.876 25.770  1.00 62.57  ?  135 SER B N   1 
ATOM   3238 C CA  . SER B 1 141 ? 31.840  -42.982 24.734  1.00 58.96  ?  135 SER B CA  1 
ATOM   3239 C C   . SER B 1 141 ? 32.550  -41.632 24.744  1.00 53.82  ?  135 SER B C   1 
ATOM   3240 O O   . SER B 1 141 ? 32.987  -41.138 23.693  1.00 52.66  ?  135 SER B O   1 
ATOM   3241 C CB  . SER B 1 141 ? 30.348  -42.768 24.934  1.00 61.45  ?  135 SER B CB  1 
ATOM   3242 O OG  . SER B 1 141 ? 29.693  -43.962 25.282  1.00 62.05  ?  135 SER B OG  1 
ATOM   3243 N N   . MET B 1 142 ? 32.685  -41.028 25.926  1.00 50.34  ?  136 MET B N   1 
ATOM   3244 C CA  . MET B 1 142 ? 33.408  -39.762 26.036  1.00 51.66  ?  136 MET B CA  1 
ATOM   3245 C C   . MET B 1 142 ? 34.827  -39.885 25.491  1.00 55.73  ?  136 MET B C   1 
ATOM   3246 O O   . MET B 1 142 ? 35.265  -39.060 24.679  1.00 53.36  ?  136 MET B O   1 
ATOM   3247 C CB  . MET B 1 142 ? 33.407  -39.295 27.488  1.00 49.63  ?  136 MET B CB  1 
ATOM   3248 C CG  . MET B 1 142 ? 31.988  -39.171 28.058  1.00 51.42  ?  136 MET B CG  1 
ATOM   3249 S SD  . MET B 1 142 ? 31.974  -38.701 29.800  1.00 58.26  ?  136 MET B SD  1 
ATOM   3250 C CE  . MET B 1 142 ? 32.592  -37.017 29.701  1.00 50.50  ?  136 MET B CE  1 
ATOM   3251 N N   . ILE B 1 143 ? 35.538  -40.952 25.887  1.00 60.40  ?  137 ILE B N   1 
ATOM   3252 C CA  . ILE B 1 143 ? 36.927  -41.160 25.473  1.00 56.06  ?  137 ILE B CA  1 
ATOM   3253 C C   . ILE B 1 143 ? 37.028  -41.393 23.963  1.00 56.06  ?  137 ILE B C   1 
ATOM   3254 O O   . ILE B 1 143 ? 37.869  -40.792 23.280  1.00 54.53  ?  137 ILE B O   1 
ATOM   3255 C CB  . ILE B 1 143 ? 37.539  -42.334 26.257  1.00 60.38  ?  137 ILE B CB  1 
ATOM   3256 C CG1 . ILE B 1 143 ? 37.400  -42.093 27.750  1.00 58.08  ?  137 ILE B CG1 1 
ATOM   3257 C CG2 . ILE B 1 143 ? 39.013  -42.502 25.897  1.00 61.56  ?  137 ILE B CG2 1 
ATOM   3258 C CD1 . ILE B 1 143 ? 38.210  -40.916 28.197  1.00 61.41  ?  137 ILE B CD1 1 
ATOM   3259 N N   . ARG B 1 144 ? 36.216  -42.316 23.434  1.00 52.82  ?  138 ARG B N   1 
ATOM   3260 C CA  . ARG B 1 144 ? 36.104  -42.492 21.989  1.00 52.00  ?  138 ARG B CA  1 
ATOM   3261 C C   . ARG B 1 144 ? 35.934  -41.159 21.278  1.00 55.49  ?  138 ARG B C   1 
ATOM   3262 O O   . ARG B 1 144 ? 36.542  -40.912 20.231  1.00 53.67  ?  138 ARG B O   1 
ATOM   3263 C CB  . ARG B 1 144 ? 34.903  -43.386 21.669  1.00 56.13  ?  138 ARG B CB  1 
ATOM   3264 C CG  . ARG B 1 144 ? 35.265  -44.774 21.188  1.00 62.10  ?  138 ARG B CG  1 
ATOM   3265 C CD  . ARG B 1 144 ? 34.060  -45.528 20.625  1.00 59.10  ?  138 ARG B CD  1 
ATOM   3266 N NE  . ARG B 1 144 ? 32.877  -45.494 21.479  1.00 66.77  ?  138 ARG B NE  1 
ATOM   3267 C CZ  . ARG B 1 144 ? 32.600  -46.375 22.436  1.00 64.83  ?  138 ARG B CZ  1 
ATOM   3268 N NH1 . ARG B 1 144 ? 33.477  -47.297 22.804  1.00 66.74  ?  138 ARG B NH1 1 
ATOM   3269 N NH2 . ARG B 1 144 ? 31.410  -46.325 23.041  1.00 63.63  ?  138 ARG B NH2 1 
ATOM   3270 N N   . SER B 1 145 ? 35.091  -40.286 21.825  1.00 55.40  ?  139 SER B N   1 
ATOM   3271 C CA  . SER B 1 145 ? 34.792  -39.055 21.113  1.00 56.04  ?  139 SER B CA  1 
ATOM   3272 C C   . SER B 1 145 ? 35.969  -38.090 21.163  1.00 54.41  ?  139 SER B C   1 
ATOM   3273 O O   . SER B 1 145 ? 36.273  -37.435 20.159  1.00 55.84  ?  139 SER B O   1 
ATOM   3274 C CB  . SER B 1 145 ? 33.512  -38.445 21.668  1.00 53.64  ?  139 SER B CB  1 
ATOM   3275 O OG  . SER B 1 145 ? 32.441  -39.385 21.537  1.00 55.65  ?  139 SER B OG  1 
ATOM   3276 N N   . ILE B 1 146 ? 36.677  -38.012 22.293  1.00 46.34  ?  140 ILE B N   1 
ATOM   3277 C CA  . ILE B 1 146 ? 37.867  -37.167 22.313  1.00 50.06  ?  140 ILE B CA  1 
ATOM   3278 C C   . ILE B 1 146 ? 38.895  -37.650 21.283  1.00 56.72  ?  140 ILE B C   1 
ATOM   3279 O O   . ILE B 1 146 ? 39.503  -36.840 20.567  1.00 53.84  ?  140 ILE B O   1 
ATOM   3280 C CB  . ILE B 1 146 ? 38.469  -37.100 23.724  1.00 50.73  ?  140 ILE B CB  1 
ATOM   3281 C CG1 . ILE B 1 146 ? 37.436  -36.583 24.723  1.00 54.58  ?  140 ILE B CG1 1 
ATOM   3282 C CG2 . ILE B 1 146 ? 39.596  -36.142 23.731  1.00 52.66  ?  140 ILE B CG2 1 
ATOM   3283 C CD1 . ILE B 1 146 ? 37.971  -36.435 26.108  1.00 52.63  ?  140 ILE B CD1 1 
ATOM   3284 N N   . LEU B 1 147 ? 39.089  -38.973 21.167  1.00 54.16  ?  141 LEU B N   1 
ATOM   3285 C CA  . LEU B 1 147 ? 40.029  -39.485 20.170  1.00 57.16  ?  141 LEU B CA  1 
ATOM   3286 C C   . LEU B 1 147 ? 39.637  -39.055 18.758  1.00 56.61  ?  141 LEU B C   1 
ATOM   3287 O O   . LEU B 1 147 ? 40.484  -38.575 17.990  1.00 57.05  ?  141 LEU B O   1 
ATOM   3288 C CB  . LEU B 1 147 ? 40.138  -41.009 20.263  1.00 53.53  ?  141 LEU B CB  1 
ATOM   3289 C CG  . LEU B 1 147 ? 40.451  -41.595 21.640  1.00 51.28  ?  141 LEU B CG  1 
ATOM   3290 C CD1 . LEU B 1 147 ? 40.452  -43.092 21.531  1.00 54.27  ?  141 LEU B CD1 1 
ATOM   3291 C CD2 . LEU B 1 147 ? 41.782  -41.091 22.156  1.00 52.66  ?  141 LEU B CD2 1 
ATOM   3292 N N   . GLU B 1 148 ? 38.347  -39.180 18.412  1.00 49.96  ?  142 GLU B N   1 
ATOM   3293 C CA  . GLU B 1 148 ? 37.902  -38.864 17.054  1.00 54.67  ?  142 GLU B CA  1 
ATOM   3294 C C   . GLU B 1 148 ? 38.223  -37.418 16.654  1.00 60.56  ?  142 GLU B C   1 
ATOM   3295 O O   . GLU B 1 148 ? 38.697  -37.176 15.537  1.00 59.77  ?  142 GLU B O   1 
ATOM   3296 C CB  . GLU B 1 148 ? 36.407  -39.137 16.910  1.00 56.25  ?  142 GLU B CB  1 
ATOM   3297 C CG  . GLU B 1 148 ? 36.122  -40.531 16.359  1.00 63.94  ?  142 GLU B CG  1 
ATOM   3298 C CD  . GLU B 1 148 ? 35.693  -40.520 14.909  1.00 68.80  ?  142 GLU B CD  1 
ATOM   3299 O OE1 . GLU B 1 148 ? 35.476  -39.427 14.349  1.00 72.94  ?  142 GLU B OE1 1 
ATOM   3300 O OE2 . GLU B 1 148 ? 35.629  -41.610 14.308  1.00 73.80  -1 142 GLU B OE2 1 
ATOM   3301 N N   . PHE B 1 149 ? 37.973  -36.433 17.531  1.00 50.66  ?  143 PHE B N   1 
ATOM   3302 C CA  . PHE B 1 149 ? 38.268  -35.081 17.078  1.00 51.24  ?  143 PHE B CA  1 
ATOM   3303 C C   . PHE B 1 149 ? 39.757  -34.782 17.160  1.00 51.55  ?  143 PHE B C   1 
ATOM   3304 O O   . PHE B 1 149 ? 40.260  -33.945 16.408  1.00 48.93  ?  143 PHE B O   1 
ATOM   3305 C CB  . PHE B 1 149 ? 37.390  -34.039 17.825  1.00 52.40  ?  143 PHE B CB  1 
ATOM   3306 C CG  . PHE B 1 149 ? 37.842  -33.664 19.219  1.00 51.20  ?  143 PHE B CG  1 
ATOM   3307 C CD1 . PHE B 1 149 ? 38.972  -32.868 19.429  1.00 46.90  ?  143 PHE B CD1 1 
ATOM   3308 C CD2 . PHE B 1 149 ? 37.073  -34.037 20.323  1.00 48.11  ?  143 PHE B CD2 1 
ATOM   3309 C CE1 . PHE B 1 149 ? 39.363  -32.501 20.732  1.00 49.60  ?  143 PHE B CE1 1 
ATOM   3310 C CE2 . PHE B 1 149 ? 37.456  -33.671 21.615  1.00 49.83  ?  143 PHE B CE2 1 
ATOM   3311 C CZ  . PHE B 1 149 ? 38.604  -32.888 21.815  1.00 49.43  ?  143 PHE B CZ  1 
ATOM   3312 N N   . MET B 1 150 ? 40.473  -35.519 18.003  1.00 56.30  ?  144 MET B N   1 
ATOM   3313 C CA  . MET B 1 150 ? 41.913  -35.380 18.112  1.00 51.85  ?  144 MET B CA  1 
ATOM   3314 C C   . MET B 1 150 ? 42.617  -35.914 16.865  1.00 53.88  ?  144 MET B C   1 
ATOM   3315 O O   . MET B 1 150 ? 43.713  -35.447 16.515  1.00 54.51  ?  144 MET B O   1 
ATOM   3316 C CB  . MET B 1 150 ? 42.368  -36.135 19.354  1.00 53.58  ?  144 MET B CB  1 
ATOM   3317 C CG  . MET B 1 150 ? 42.588  -35.248 20.531  1.00 56.22  ?  144 MET B CG  1 
ATOM   3318 S SD  . MET B 1 150 ? 43.370  -36.116 21.885  1.00 55.48  ?  144 MET B SD  1 
ATOM   3319 C CE  . MET B 1 150 ? 42.375  -37.617 21.987  1.00 54.86  ?  144 MET B CE  1 
ATOM   3320 N N   . ALA B 1 151 ? 42.006  -36.884 16.181  1.00 52.28  ?  145 ALA B N   1 
ATOM   3321 C CA  . ALA B 1 151 ? 42.579  -37.456 14.959  1.00 59.15  ?  145 ALA B CA  1 
ATOM   3322 C C   . ALA B 1 151 ? 41.456  -37.925 14.048  1.00 57.26  ?  145 ALA B C   1 
ATOM   3323 O O   . ALA B 1 151 ? 41.113  -39.108 14.020  1.00 58.79  ?  145 ALA B O   1 
ATOM   3324 C CB  . ALA B 1 151 ? 43.536  -38.606 15.277  1.00 55.87  ?  145 ALA B CB  1 
ATOM   3325 N N   . PRO B 1 152 ? 40.872  -37.013 13.257  1.00 58.57  ?  146 PRO B N   1 
ATOM   3326 C CA  . PRO B 1 152 ? 39.622  -37.347 12.550  1.00 52.31  ?  146 PRO B CA  1 
ATOM   3327 C C   . PRO B 1 152 ? 39.752  -38.446 11.507  1.00 56.52  ?  146 PRO B C   1 
ATOM   3328 O O   . PRO B 1 152 ? 38.759  -39.114 11.202  1.00 59.54  ?  146 PRO B O   1 
ATOM   3329 C CB  . PRO B 1 152 ? 39.206  -36.012 11.914  1.00 48.69  ?  146 PRO B CB  1 
ATOM   3330 C CG  . PRO B 1 152 ? 40.368  -35.106 12.031  1.00 52.70  ?  146 PRO B CG  1 
ATOM   3331 C CD  . PRO B 1 152 ? 41.193  -35.575 13.181  1.00 54.99  ?  146 PRO B CD  1 
ATOM   3332 N N   . TYR B 1 153 ? 40.919  -38.674 10.938  1.00 57.08  ?  147 TYR B N   1 
ATOM   3333 C CA  . TYR B 1 153 ? 41.057  -39.748 9.967   1.00 64.94  ?  147 TYR B CA  1 
ATOM   3334 C C   . TYR B 1 153 ? 41.653  -40.958 10.670  1.00 62.79  ?  147 TYR B C   1 
ATOM   3335 O O   . TYR B 1 153 ? 42.626  -40.815 11.415  1.00 62.36  ?  147 TYR B O   1 
ATOM   3336 C CB  . TYR B 1 153 ? 41.933  -39.327 8.788   1.00 62.41  ?  147 TYR B CB  1 
ATOM   3337 C CG  . TYR B 1 153 ? 41.359  -38.236 7.922   1.00 63.94  ?  147 TYR B CG  1 
ATOM   3338 C CD1 . TYR B 1 153 ? 39.999  -38.039 7.806   1.00 73.07  ?  147 TYR B CD1 1 
ATOM   3339 C CD2 . TYR B 1 153 ? 42.192  -37.398 7.213   1.00 73.76  ?  147 TYR B CD2 1 
ATOM   3340 C CE1 . TYR B 1 153 ? 39.486  -37.014 6.996   1.00 74.41  ?  147 TYR B CE1 1 
ATOM   3341 C CE2 . TYR B 1 153 ? 41.697  -36.391 6.406   1.00 73.21  ?  147 TYR B CE2 1 
ATOM   3342 C CZ  . TYR B 1 153 ? 40.354  -36.203 6.301   1.00 69.89  ?  147 TYR B CZ  1 
ATOM   3343 O OH  . TYR B 1 153 ? 39.913  -35.182 5.496   1.00 78.07  ?  147 TYR B OH  1 
ATOM   3344 N N   . GLY B 1 154 ? 41.071  -42.138 10.456  1.00 57.41  ?  148 GLY B N   1 
ATOM   3345 C CA  . GLY B 1 154 ? 41.682  -43.324 11.025  1.00 58.49  ?  148 GLY B CA  1 
ATOM   3346 C C   . GLY B 1 154 ? 40.638  -44.263 11.580  1.00 60.14  ?  148 GLY B C   1 
ATOM   3347 O O   . GLY B 1 154 ? 39.465  -44.185 11.221  1.00 66.01  ?  148 GLY B O   1 
ATOM   3348 N N   . ILE B 1 155 ? 41.063  -45.167 12.461  1.00 54.44  ?  149 ILE B N   1 
ATOM   3349 C CA  . ILE B 1 155 ? 40.173  -46.199 12.985  1.00 58.68  ?  149 ILE B CA  1 
ATOM   3350 C C   . ILE B 1 155 ? 40.414  -46.356 14.476  1.00 60.15  ?  149 ILE B C   1 
ATOM   3351 O O   . ILE B 1 155 ? 41.547  -46.234 14.958  1.00 58.49  ?  149 ILE B O   1 
ATOM   3352 C CB  . ILE B 1 155 ? 40.351  -47.567 12.291  1.00 62.90  ?  149 ILE B CB  1 
ATOM   3353 C CG1 . ILE B 1 155 ? 40.419  -47.435 10.766  1.00 62.42  ?  149 ILE B CG1 1 
ATOM   3354 C CG2 . ILE B 1 155 ? 39.222  -48.502 12.690  1.00 59.67  ?  149 ILE B CG2 1 
ATOM   3355 C CD1 . ILE B 1 155 ? 40.618  -48.777 10.049  1.00 66.23  ?  149 ILE B CD1 1 
ATOM   3356 N N   . THR B 1 156 ? 39.336  -46.625 15.204  1.00 59.25  ?  150 THR B N   1 
ATOM   3357 C CA  . THR B 1 156 ? 39.391  -46.878 16.632  1.00 60.55  ?  150 THR B CA  1 
ATOM   3358 C C   . THR B 1 156 ? 38.902  -48.290 16.882  1.00 59.30  ?  150 THR B C   1 
ATOM   3359 O O   . THR B 1 156 ? 37.862  -48.699 16.353  1.00 60.77  ?  150 THR B O   1 
ATOM   3360 C CB  . THR B 1 156 ? 38.531  -45.883 17.418  1.00 59.92  ?  150 THR B CB  1 
ATOM   3361 O OG1 . THR B 1 156 ? 39.121  -44.583 17.329  1.00 57.86  ?  150 THR B OG1 1 
ATOM   3362 C CG2 . THR B 1 156 ? 38.446  -46.307 18.888  1.00 58.62  ?  150 THR B CG2 1 
ATOM   3363 N N   . TYR B 1 157 ? 39.651  -49.034 17.673  1.00 62.36  ?  151 TYR B N   1 
ATOM   3364 C CA  . TYR B 1 157 ? 39.237  -50.361 18.082  1.00 62.96  ?  151 TYR B CA  1 
ATOM   3365 C C   . TYR B 1 157 ? 38.988  -50.330 19.583  1.00 63.90  ?  151 TYR B C   1 
ATOM   3366 O O   . TYR B 1 157 ? 39.816  -49.817 20.349  1.00 64.47  ?  151 TYR B O   1 
ATOM   3367 C CB  . TYR B 1 157 ? 40.286  -51.403 17.686  1.00 62.23  ?  151 TYR B CB  1 
ATOM   3368 C CG  . TYR B 1 157 ? 40.465  -51.517 16.184  1.00 63.35  ?  151 TYR B CG  1 
ATOM   3369 C CD1 . TYR B 1 157 ? 39.364  -51.682 15.345  1.00 63.51  ?  151 TYR B CD1 1 
ATOM   3370 C CD2 . TYR B 1 157 ? 41.738  -51.455 15.599  1.00 66.08  ?  151 TYR B CD2 1 
ATOM   3371 C CE1 . TYR B 1 157 ? 39.520  -51.789 13.960  1.00 63.97  ?  151 TYR B CE1 1 
ATOM   3372 C CE2 . TYR B 1 157 ? 41.909  -51.561 14.212  1.00 59.10  ?  151 TYR B CE2 1 
ATOM   3373 C CZ  . TYR B 1 157 ? 40.790  -51.720 13.401  1.00 68.16  ?  151 TYR B CZ  1 
ATOM   3374 O OH  . TYR B 1 157 ? 40.936  -51.818 12.032  1.00 72.96  ?  151 TYR B OH  1 
ATOM   3375 N N   . THR B 1 158 ? 37.817  -50.804 19.986  1.00 62.78  ?  152 THR B N   1 
ATOM   3376 C CA  . THR B 1 158 ? 37.487  -51.006 21.386  1.00 60.28  ?  152 THR B CA  1 
ATOM   3377 C C   . THR B 1 158 ? 37.556  -52.502 21.645  1.00 66.35  ?  152 THR B C   1 
ATOM   3378 O O   . THR B 1 158 ? 36.761  -53.267 21.096  1.00 66.23  ?  152 THR B O   1 
ATOM   3379 C CB  . THR B 1 158 ? 36.103  -50.469 21.716  1.00 65.85  ?  152 THR B CB  1 
ATOM   3380 O OG1 . THR B 1 158 ? 35.962  -49.122 21.217  1.00 69.27  ?  152 THR B OG1 1 
ATOM   3381 C CG2 . THR B 1 158 ? 35.882  -50.516 23.220  1.00 68.28  ?  152 THR B CG2 1 
ATOM   3382 N N   . ASN B 1 159 ? 38.508  -52.915 22.469  1.00 66.15  ?  153 ASN B N   1 
ATOM   3383 C CA  . ASN B 1 159 ? 38.771  -54.323 22.736  1.00 66.82  ?  153 ASN B CA  1 
ATOM   3384 C C   . ASN B 1 159 ? 38.382  -54.608 24.173  1.00 66.48  ?  153 ASN B C   1 
ATOM   3385 O O   . ASN B 1 159 ? 39.085  -54.206 25.108  1.00 67.96  ?  153 ASN B O   1 
ATOM   3386 C CB  . ASN B 1 159 ? 40.235  -54.644 22.468  1.00 60.69  ?  153 ASN B CB  1 
ATOM   3387 C CG  . ASN B 1 159 ? 40.594  -54.435 21.015  1.00 63.97  ?  153 ASN B CG  1 
ATOM   3388 O OD1 . ASN B 1 159 ? 40.097  -55.156 20.130  1.00 68.97  ?  153 ASN B OD1 1 
ATOM   3389 N ND2 . ASN B 1 159 ? 41.427  -53.429 20.747  1.00 60.63  ?  153 ASN B ND2 1 
ATOM   3390 N N   . VAL B 1 160 ? 37.263  -55.301 24.351  1.00 68.20  ?  154 VAL B N   1 
ATOM   3391 C CA  . VAL B 1 160 ? 36.645  -55.413 25.672  1.00 75.29  ?  154 VAL B CA  1 
ATOM   3392 C C   . VAL B 1 160 ? 37.178  -56.687 26.318  1.00 74.58  ?  154 VAL B C   1 
ATOM   3393 O O   . VAL B 1 160 ? 36.659  -57.783 26.116  1.00 69.38  ?  154 VAL B O   1 
ATOM   3394 C CB  . VAL B 1 160 ? 35.133  -55.377 25.598  1.00 65.47  ?  154 VAL B CB  1 
ATOM   3395 C CG1 . VAL B 1 160 ? 34.591  -55.565 26.981  1.00 66.99  ?  154 VAL B CG1 1 
ATOM   3396 C CG2 . VAL B 1 160 ? 34.732  -54.037 25.027  1.00 66.36  ?  154 VAL B CG2 1 
ATOM   3397 N N   . GLY B 1 161 ? 38.241  -56.512 27.115  1.00 83.80  ?  155 GLY B N   1 
ATOM   3398 C CA  . GLY B 1 161 ? 39.046  -57.586 27.658  1.00 78.42  ?  155 GLY B CA  1 
ATOM   3399 C C   . GLY B 1 161 ? 38.217  -58.580 28.416  1.00 81.77  ?  155 GLY B C   1 
ATOM   3400 O O   . GLY B 1 161 ? 37.044  -58.316 28.742  1.00 76.29  ?  155 GLY B O   1 
ATOM   3401 N N   . PRO B 1 162 ? 38.832  -59.780 28.713  1.00 85.70  ?  156 PRO B N   1 
ATOM   3402 C CA  . PRO B 1 162 ? 38.076  -60.896 29.301  1.00 82.99  ?  156 PRO B CA  1 
ATOM   3403 C C   . PRO B 1 162 ? 37.125  -60.423 30.387  1.00 79.56  ?  156 PRO B C   1 
ATOM   3404 O O   . PRO B 1 162 ? 37.468  -59.588 31.233  1.00 74.74  ?  156 PRO B O   1 
ATOM   3405 C CB  . PRO B 1 162 ? 39.179  -61.812 29.834  1.00 78.12  ?  156 PRO B CB  1 
ATOM   3406 C CG  . PRO B 1 162 ? 40.304  -61.572 28.899  1.00 75.25  ?  156 PRO B CG  1 
ATOM   3407 C CD  . PRO B 1 162 ? 40.256  -60.120 28.541  1.00 77.11  ?  156 PRO B CD  1 
ATOM   3408 N N   . GLY B 1 163 ? 35.891  -60.884 30.313  1.00 73.89  ?  157 GLY B N   1 
ATOM   3409 C CA  . GLY B 1 163 ? 34.895  -60.271 31.148  1.00 83.10  ?  157 GLY B CA  1 
ATOM   3410 C C   . GLY B 1 163 ? 33.490  -60.686 30.793  1.00 89.22  ?  157 GLY B C   1 
ATOM   3411 O O   . GLY B 1 163 ? 33.089  -60.707 29.622  1.00 87.53  ?  157 GLY B O   1 
ATOM   3412 N N   . MET B 1 164 ? 32.740  -60.998 31.843  1.00 91.07  ?  158 MET B N   1 
ATOM   3413 C CA  . MET B 1 164 ? 31.396  -61.536 31.723  1.00 94.42  ?  158 MET B CA  1 
ATOM   3414 C C   . MET B 1 164 ? 30.522  -60.651 30.844  1.00 93.11  ?  158 MET B C   1 
ATOM   3415 O O   . MET B 1 164 ? 30.580  -59.420 30.920  1.00 98.95  ?  158 MET B O   1 
ATOM   3416 C CB  . MET B 1 164 ? 30.821  -61.655 33.127  1.00 85.98  ?  158 MET B CB  1 
ATOM   3417 C CG  . MET B 1 164 ? 29.417  -62.089 33.233  1.00 90.57  ?  158 MET B CG  1 
ATOM   3418 S SD  . MET B 1 164 ? 29.301  -62.664 34.927  1.00 98.55  ?  158 MET B SD  1 
ATOM   3419 C CE  . MET B 1 164 ? 30.250  -61.359 35.734  1.00 76.47  ?  158 MET B CE  1 
ATOM   3420 N N   . SER B 1 165 ? 29.743  -61.281 29.974  1.00 88.81  ?  159 SER B N   1 
ATOM   3421 C CA  . SER B 1 165 ? 28.758  -60.557 29.187  1.00 97.45  ?  159 SER B CA  1 
ATOM   3422 C C   . SER B 1 165 ? 27.516  -60.364 30.059  1.00 106.34 ?  159 SER B C   1 
ATOM   3423 O O   . SER B 1 165 ? 27.557  -60.556 31.276  1.00 108.98 ?  159 SER B O   1 
ATOM   3424 C CB  . SER B 1 165 ? 28.480  -61.302 27.887  1.00 102.80 ?  159 SER B CB  1 
ATOM   3425 O OG  . SER B 1 165 ? 27.311  -60.819 27.257  1.00 109.64 ?  159 SER B OG  1 
ATOM   3426 N N   . MET B 1 166 ? 26.393  -59.959 29.466  1.00 116.63 ?  160 MET B N   1 
ATOM   3427 C CA  . MET B 1 166 ? 25.125  -60.021 30.193  1.00 118.58 ?  160 MET B CA  1 
ATOM   3428 C C   . MET B 1 166 ? 24.036  -60.569 29.276  1.00 117.91 ?  160 MET B C   1 
ATOM   3429 O O   . MET B 1 166 ? 23.336  -61.520 29.641  1.00 117.49 ?  160 MET B O   1 
ATOM   3430 C CB  . MET B 1 166 ? 24.735  -58.652 30.788  1.00 111.45 ?  160 MET B CB  1 
ATOM   3431 C CG  . MET B 1 166 ? 24.546  -57.474 29.810  1.00 114.31 ?  160 MET B CG  1 
ATOM   3432 S SD  . MET B 1 166 ? 22.890  -57.289 29.075  1.00 123.64 ?  160 MET B SD  1 
ATOM   3433 C CE  . MET B 1 166 ? 22.216  -55.888 29.970  1.00 88.30  ?  160 MET B CE  1 
ATOM   3434 N N   . GLY B 1 167 ? 23.909  -60.000 28.076  1.00 115.96 ?  161 GLY B N   1 
ATOM   3435 C CA  . GLY B 1 167 ? 22.926  -60.509 27.135  1.00 120.47 ?  161 GLY B CA  1 
ATOM   3436 C C   . GLY B 1 167 ? 23.278  -61.895 26.630  1.00 121.99 ?  161 GLY B C   1 
ATOM   3437 O O   . GLY B 1 167 ? 22.417  -62.778 26.546  1.00 122.15 ?  161 GLY B O   1 
ATOM   3438 N N   . HIS B 1 168 ? 24.552  -62.102 26.281  1.00 118.42 ?  162 HIS B N   1 
ATOM   3439 C CA  . HIS B 1 168 ? 24.988  -63.418 25.824  1.00 118.96 ?  162 HIS B CA  1 
ATOM   3440 C C   . HIS B 1 168 ? 24.836  -64.464 26.924  1.00 118.66 ?  162 HIS B C   1 
ATOM   3441 O O   . HIS B 1 168 ? 24.352  -65.575 26.669  1.00 120.31 ?  162 HIS B O   1 
ATOM   3442 C CB  . HIS B 1 168 ? 26.439  -63.362 25.338  1.00 119.91 ?  162 HIS B CB  1 
ATOM   3443 C CG  . HIS B 1 168 ? 26.622  -62.714 23.996  1.00 120.60 ?  162 HIS B CG  1 
ATOM   3444 N ND1 . HIS B 1 168 ? 27.571  -61.740 23.765  1.00 117.93 ?  162 HIS B ND1 1 
ATOM   3445 C CD2 . HIS B 1 168 ? 25.991  -62.913 22.812  1.00 119.98 ?  162 HIS B CD2 1 
ATOM   3446 C CE1 . HIS B 1 168 ? 27.513  -61.362 22.501  1.00 115.54 ?  162 HIS B CE1 1 
ATOM   3447 N NE2 . HIS B 1 168 ? 26.564  -62.059 21.900  1.00 120.31 ?  162 HIS B NE2 1 
ATOM   3448 N N   . SER B 1 169 ? 25.248  -64.124 28.154  1.00 115.45 ?  163 SER B N   1 
ATOM   3449 C CA  . SER B 1 169 ? 25.109  -65.046 29.281  1.00 113.95 ?  163 SER B CA  1 
ATOM   3450 C C   . SER B 1 169 ? 23.663  -65.491 29.443  1.00 120.17 ?  163 SER B C   1 
ATOM   3451 O O   . SER B 1 169 ? 23.370  -66.694 29.483  1.00 117.56 ?  163 SER B O   1 
ATOM   3452 C CB  . SER B 1 169 ? 25.617  -64.392 30.572  1.00 108.33 ?  163 SER B CB  1 
ATOM   3453 O OG  . SER B 1 169 ? 26.830  -64.978 31.024  1.00 96.52  ?  163 SER B OG  1 
ATOM   3454 N N   . VAL B 1 170 ? 22.741  -64.524 29.514  1.00 121.57 ?  164 VAL B N   1 
ATOM   3455 C CA  . VAL B 1 170 ? 21.325  -64.841 29.664  1.00 124.40 ?  164 VAL B CA  1 
ATOM   3456 C C   . VAL B 1 170 ? 20.779  -65.506 28.399  1.00 123.45 ?  164 VAL B C   1 
ATOM   3457 O O   . VAL B 1 170 ? 19.854  -66.326 28.472  1.00 123.50 ?  164 VAL B O   1 
ATOM   3458 C CB  . VAL B 1 170 ? 20.531  -63.572 30.051  1.00 124.89 ?  164 VAL B CB  1 
ATOM   3459 C CG1 . VAL B 1 170 ? 21.133  -62.913 31.302  1.00 118.39 ?  164 VAL B CG1 1 
ATOM   3460 C CG2 . VAL B 1 170 ? 20.467  -62.577 28.898  1.00 121.78 ?  164 VAL B CG2 1 
ATOM   3461 N N   . ALA B 1 171 ? 21.345  -65.189 27.231  1.00 121.93 ?  165 ALA B N   1 
ATOM   3462 C CA  . ALA B 1 171 ? 20.933  -65.857 26.000  1.00 122.53 ?  165 ALA B CA  1 
ATOM   3463 C C   . ALA B 1 171 ? 21.112  -67.368 26.114  1.00 125.17 ?  165 ALA B C   1 
ATOM   3464 O O   . ALA B 1 171 ? 20.161  -68.138 25.934  1.00 121.77 ?  165 ALA B O   1 
ATOM   3465 C CB  . ALA B 1 171 ? 21.726  -65.301 24.815  1.00 116.73 ?  165 ALA B CB  1 
ATOM   3466 N N   . VAL B 1 172 ? 22.334  -67.811 26.428  1.00 126.38 ?  166 VAL B N   1 
ATOM   3467 C CA  . VAL B 1 172 ? 22.601  -69.242 26.548  1.00 124.97 ?  166 VAL B CA  1 
ATOM   3468 C C   . VAL B 1 172 ? 21.922  -69.817 27.781  1.00 125.42 ?  166 VAL B C   1 
ATOM   3469 O O   . VAL B 1 172 ? 21.558  -71.003 27.801  1.00 123.05 ?  166 VAL B O   1 
ATOM   3470 C CB  . VAL B 1 172 ? 24.119  -69.508 26.577  1.00 121.47 ?  166 VAL B CB  1 
ATOM   3471 C CG1 . VAL B 1 172 ? 24.418  -71.011 26.438  1.00 115.03 ?  166 VAL B CG1 1 
ATOM   3472 C CG2 . VAL B 1 172 ? 24.819  -68.703 25.491  1.00 123.30 ?  166 VAL B CG2 1 
ATOM   3473 N N   . LYS B 1 173 ? 21.743  -68.996 28.823  1.00 124.65 ?  167 LYS B N   1 
ATOM   3474 C CA  . LYS B 1 173 ? 21.128  -69.469 30.060  1.00 126.06 ?  167 LYS B CA  1 
ATOM   3475 C C   . LYS B 1 173 ? 19.754  -70.081 29.804  1.00 127.75 ?  167 LYS B C   1 
ATOM   3476 O O   . LYS B 1 173 ? 19.340  -71.000 30.523  1.00 130.94 ?  167 LYS B O   1 
ATOM   3477 C CB  . LYS B 1 173 ? 21.051  -68.319 31.071  1.00 126.10 ?  167 LYS B CB  1 
ATOM   3478 C CG  . LYS B 1 173 ? 20.038  -68.493 32.191  1.00 128.73 ?  167 LYS B CG  1 
ATOM   3479 C CD  . LYS B 1 173 ? 19.056  -67.324 32.231  1.00 132.25 ?  167 LYS B CD  1 
ATOM   3480 C CE  . LYS B 1 173 ? 17.672  -67.741 31.740  1.00 130.62 ?  167 LYS B CE  1 
ATOM   3481 N NZ  . LYS B 1 173 ? 17.345  -67.160 30.405  1.00 129.35 ?  167 LYS B NZ  1 
ATOM   3482 N N   . ALA B 1 174 ? 19.050  -69.617 28.768  1.00 127.52 ?  168 ALA B N   1 
ATOM   3483 C CA  . ALA B 1 174 ? 17.817  -70.269 28.338  1.00 129.43 ?  168 ALA B CA  1 
ATOM   3484 C C   . ALA B 1 174 ? 18.125  -71.537 27.540  1.00 128.79 ?  168 ALA B C   1 
ATOM   3485 O O   . ALA B 1 174 ? 18.718  -72.481 28.076  1.00 127.54 ?  168 ALA B O   1 
ATOM   3486 C CB  . ALA B 1 174 ? 16.959  -69.305 27.516  1.00 125.91 ?  168 ALA B CB  1 
ATOM   3487 N N   . ILE B 1 175 ? 17.755  -71.546 26.253  1.00 126.34 ?  169 ILE B N   1 
ATOM   3488 C CA  . ILE B 1 175 ? 17.850  -72.692 25.339  1.00 128.91 ?  169 ILE B CA  1 
ATOM   3489 C C   . ILE B 1 175 ? 17.637  -74.035 26.034  1.00 123.38 ?  169 ILE B C   1 
ATOM   3490 O O   . ILE B 1 175 ? 16.750  -74.175 26.882  1.00 122.69 ?  169 ILE B O   1 
ATOM   3491 C CB  . ILE B 1 175 ? 19.182  -72.707 24.557  1.00 128.04 ?  169 ILE B CB  1 
ATOM   3492 C CG1 . ILE B 1 175 ? 20.119  -71.578 24.978  1.00 125.96 ?  169 ILE B CG1 1 
ATOM   3493 C CG2 . ILE B 1 175 ? 18.921  -72.629 23.056  1.00 129.89 ?  169 ILE B CG2 1 
ATOM   3494 C CD1 . ILE B 1 175 ? 21.496  -71.740 24.399  1.00 127.79 ?  169 ILE B CD1 1 
ATOM   3495 N N   . GLU B 1 176 ? 18.449  -75.032 25.670  1.00 118.83 ?  170 GLU B N   1 
ATOM   3496 C CA  . GLU B 1 176 ? 18.160  -76.423 26.010  1.00 119.42 ?  170 GLU B CA  1 
ATOM   3497 C C   . GLU B 1 176 ? 18.523  -76.763 27.448  1.00 118.49 ?  170 GLU B C   1 
ATOM   3498 O O   . GLU B 1 176 ? 18.376  -75.924 28.342  1.00 120.24 ?  170 GLU B O   1 
ATOM   3499 C CB  . GLU B 1 176 ? 18.894  -77.371 25.062  1.00 119.69 ?  170 GLU B CB  1 
ATOM   3500 C CG  . GLU B 1 176 ? 18.006  -78.446 24.453  1.00 118.62 ?  170 GLU B CG  1 
ATOM   3501 C CD  . GLU B 1 176 ? 18.711  -79.232 23.366  1.00 118.81 ?  170 GLU B CD  1 
ATOM   3502 O OE1 . GLU B 1 176 ? 19.930  -79.042 23.188  1.00 119.41 ?  170 GLU B OE1 1 
ATOM   3503 O OE2 . GLU B 1 176 ? 18.047  -80.033 22.682  1.00 119.48 ?  170 GLU B OE2 1 
ATOM   3504 N N   . GLY B 1 177 ? 19.010  -77.990 27.663  1.00 115.13 ?  171 GLY B N   1 
ATOM   3505 C CA  . GLY B 1 177 ? 19.327  -78.469 29.024  1.00 115.60 ?  171 GLY B CA  1 
ATOM   3506 C C   . GLY B 1 177 ? 20.367  -77.620 29.719  1.00 113.65 ?  171 GLY B C   1 
ATOM   3507 O O   . GLY B 1 177 ? 21.234  -78.190 30.413  1.00 105.30 ?  171 GLY B O   1 
ATOM   3508 N N   . VAL B 1 178 ? 20.275  -76.304 29.556  1.00 118.49 ?  172 VAL B N   1 
ATOM   3509 C CA  . VAL B 1 178 ? 21.215  -75.374 30.236  1.00 117.81 ?  172 VAL B CA  1 
ATOM   3510 C C   . VAL B 1 178 ? 20.776  -75.228 31.697  1.00 113.34 ?  172 VAL B C   1 
ATOM   3511 O O   . VAL B 1 178 ? 20.004  -74.294 31.992  1.00 114.04 ?  172 VAL B O   1 
ATOM   3512 C CB  . VAL B 1 178 ? 21.235  -74.021 29.508  1.00 116.83 ?  172 VAL B CB  1 
ATOM   3513 C CG1 . VAL B 1 178 ? 22.271  -73.087 30.114  1.00 114.84 ?  172 VAL B CG1 1 
ATOM   3514 C CG2 . VAL B 1 178 ? 21.489  -74.205 28.017  1.00 118.87 ?  172 VAL B CG2 1 
ATOM   3515 N N   . LYS B 1 179 ? 21.220  -76.140 32.563  1.00 108.25 ?  173 LYS B N   1 
ATOM   3516 C CA  . LYS B 1 179 ? 20.919  -75.976 34.003  1.00 107.01 ?  173 LYS B CA  1 
ATOM   3517 C C   . LYS B 1 179 ? 21.423  -74.583 34.372  1.00 107.91 ?  173 LYS B C   1 
ATOM   3518 O O   . LYS B 1 179 ? 20.637  -73.795 34.936  1.00 104.34 ?  173 LYS B O   1 
ATOM   3519 C CB  . LYS B 1 179 ? 21.603  -77.108 34.771  1.00 30.00  ?  173 LYS B CB  1 
ATOM   3520 C CG  . LYS B 1 179 ? 21.078  -78.491 34.416  1.00 30.00  ?  173 LYS B CG  1 
ATOM   3521 C CD  . LYS B 1 179 ? 22.152  -79.566 34.310  1.00 30.00  ?  173 LYS B CD  1 
ATOM   3522 C CE  . LYS B 1 179 ? 21.972  -80.433 33.105  1.00 30.00  ?  173 LYS B CE  1 
ATOM   3523 N NZ  . LYS B 1 179 ? 20.706  -81.168 33.156  1.00 30.00  ?  173 LYS B NZ  1 
ATOM   3524 N N   . ASP B 1 180 ? 22.684  -74.301 34.051  1.00 105.33 ?  174 ASP B N   1 
ATOM   3525 C CA  . ASP B 1 180 ? 23.238  -72.939 34.260  1.00 101.35 ?  174 ASP B CA  1 
ATOM   3526 C C   . ASP B 1 180 ? 24.357  -72.755 33.242  1.00 99.97  ?  174 ASP B C   1 
ATOM   3527 O O   . ASP B 1 180 ? 24.911  -73.770 32.775  1.00 99.55  ?  174 ASP B O   1 
ATOM   3528 C CB  . ASP B 1 180 ? 23.711  -72.697 35.681  1.00 94.81  ?  174 ASP B CB  1 
ATOM   3529 C CG  . ASP B 1 180 ? 23.785  -71.235 36.093  1.00 99.32  ?  174 ASP B CG  1 
ATOM   3530 O OD1 . ASP B 1 180 ? 23.398  -70.379 35.273  1.00 99.09  -1 174 ASP B OD1 1 
ATOM   3531 O OD2 . ASP B 1 180 ? 24.227  -70.967 37.229  1.00 100.39 ?  174 ASP B OD2 1 
ATOM   3532 N N   . ALA B 1 181 ? 24.652  -71.508 32.897  1.00 98.03  ?  175 ALA B N   1 
ATOM   3533 C CA  . ALA B 1 181 ? 25.717  -71.234 31.941  1.00 89.84  ?  175 ALA B CA  1 
ATOM   3534 C C   . ALA B 1 181 ? 26.277  -69.841 32.169  1.00 90.62  ?  175 ALA B C   1 
ATOM   3535 O O   . ALA B 1 181 ? 25.614  -68.956 32.720  1.00 90.83  ?  175 ALA B O   1 
ATOM   3536 C CB  . ALA B 1 181 ? 25.247  -71.381 30.491  1.00 96.57  ?  175 ALA B CB  1 
ATOM   3537 N N   . LEU B 1 182 ? 27.527  -69.671 31.743  1.00 87.03  ?  176 LEU B N   1 
ATOM   3538 C CA  . LEU B 1 182 ? 28.225  -68.398 31.769  1.00 76.79  ?  176 LEU B CA  1 
ATOM   3539 C C   . LEU B 1 182 ? 28.801  -68.168 30.384  1.00 82.10  ?  176 LEU B C   1 
ATOM   3540 O O   . LEU B 1 182 ? 29.452  -69.057 29.826  1.00 79.19  ?  176 LEU B O   1 
ATOM   3541 C CB  . LEU B 1 182 ? 29.328  -68.400 32.826  1.00 81.82  ?  176 LEU B CB  1 
ATOM   3542 C CG  . LEU B 1 182 ? 30.268  -67.194 32.949  1.00 78.11  ?  176 LEU B CG  1 
ATOM   3543 C CD1 . LEU B 1 182 ? 29.499  -65.888 33.120  1.00 78.88  ?  176 LEU B CD1 1 
ATOM   3544 C CD2 . LEU B 1 182 ? 31.234  -67.416 34.096  1.00 70.16  ?  176 LEU B CD2 1 
ATOM   3545 N N   . ALA B 1 183 ? 28.535  -66.995 29.816  1.00 85.06  ?  177 ALA B N   1 
ATOM   3546 C CA  . ALA B 1 183 ? 28.994  -66.653 28.478  1.00 86.03  ?  177 ALA B CA  1 
ATOM   3547 C C   . ALA B 1 183 ? 29.917  -65.447 28.564  1.00 87.78  ?  177 ALA B C   1 
ATOM   3548 O O   . ALA B 1 183 ? 29.560  -64.421 29.151  1.00 92.51  ?  177 ALA B O   1 
ATOM   3549 C CB  . ALA B 1 183 ? 27.827  -66.372 27.533  1.00 89.50  ?  177 ALA B CB  1 
ATOM   3550 N N   . LEU B 1 184 ? 31.107  -65.585 28.001  1.00 82.75  ?  178 LEU B N   1 
ATOM   3551 C CA  . LEU B 1 184 ? 32.133  -64.564 28.074  1.00 84.33  ?  178 LEU B CA  1 
ATOM   3552 C C   . LEU B 1 184 ? 32.407  -64.005 26.687  1.00 83.80  ?  178 LEU B C   1 
ATOM   3553 O O   . LEU B 1 184 ? 32.313  -64.712 25.676  1.00 80.38  ?  178 LEU B O   1 
ATOM   3554 C CB  . LEU B 1 184 ? 33.435  -65.128 28.664  1.00 83.34  ?  178 LEU B CB  1 
ATOM   3555 C CG  . LEU B 1 184 ? 33.440  -65.577 30.125  1.00 77.54  ?  178 LEU B CG  1 
ATOM   3556 C CD1 . LEU B 1 184 ? 34.838  -65.525 30.662  1.00 73.76  ?  178 LEU B CD1 1 
ATOM   3557 C CD2 . LEU B 1 184 ? 32.526  -64.702 30.957  1.00 81.75  ?  178 LEU B CD2 1 
ATOM   3558 N N   . THR B 1 185 ? 32.732  -62.718 26.655  1.00 84.68  ?  179 THR B N   1 
ATOM   3559 C CA  . THR B 1 185 ? 33.317  -62.081 25.488  1.00 81.69  ?  179 THR B CA  1 
ATOM   3560 C C   . THR B 1 185 ? 34.808  -61.948 25.748  1.00 76.19  ?  179 THR B C   1 
ATOM   3561 O O   . THR B 1 185 ? 35.212  -61.463 26.808  1.00 79.54  ?  179 THR B O   1 
ATOM   3562 C CB  . THR B 1 185 ? 32.675  -60.715 25.220  1.00 85.72  ?  179 THR B CB  1 
ATOM   3563 O OG1 . THR B 1 185 ? 32.262  -60.137 26.464  1.00 90.74  ?  179 THR B OG1 1 
ATOM   3564 C CG2 . THR B 1 185 ? 31.452  -60.851 24.299  1.00 82.77  ?  179 THR B CG2 1 
ATOM   3565 N N   . ILE B 1 186 ? 35.615  -62.421 24.804  1.00 74.16  ?  180 ILE B N   1 
ATOM   3566 C CA  . ILE B 1 186 ? 37.068  -62.374 24.891  1.00 74.56  ?  180 ILE B CA  1 
ATOM   3567 C C   . ILE B 1 186 ? 37.569  -61.540 23.712  1.00 73.56  ?  180 ILE B C   1 
ATOM   3568 O O   . ILE B 1 186 ? 37.128  -61.767 22.588  1.00 73.73  ?  180 ILE B O   1 
ATOM   3569 C CB  . ILE B 1 186 ? 37.700  -63.778 24.846  1.00 76.10  ?  180 ILE B CB  1 
ATOM   3570 C CG1 . ILE B 1 186 ? 37.394  -64.588 26.111  1.00 71.77  ?  180 ILE B CG1 1 
ATOM   3571 C CG2 . ILE B 1 186 ? 39.202  -63.686 24.629  1.00 67.44  ?  180 ILE B CG2 1 
ATOM   3572 C CD1 . ILE B 1 186 ? 37.385  -63.782 27.374  1.00 80.10  ?  180 ILE B CD1 1 
ATOM   3573 N N   . PRO B 1 187 ? 38.493  -60.599 23.908  1.00 74.68  ?  181 PRO B N   1 
ATOM   3574 C CA  . PRO B 1 187 ? 39.023  -59.845 22.763  1.00 73.00  ?  181 PRO B CA  1 
ATOM   3575 C C   . PRO B 1 187 ? 40.084  -60.634 22.017  1.00 73.64  ?  181 PRO B C   1 
ATOM   3576 O O   . PRO B 1 187 ? 40.976  -61.241 22.613  1.00 75.44  ?  181 PRO B O   1 
ATOM   3577 C CB  . PRO B 1 187 ? 39.639  -58.602 23.414  1.00 70.80  ?  181 PRO B CB  1 
ATOM   3578 C CG  . PRO B 1 187 ? 40.124  -59.120 24.725  1.00 74.46  ?  181 PRO B CG  1 
ATOM   3579 C CD  . PRO B 1 187 ? 39.132  -60.185 25.169  1.00 74.17  ?  181 PRO B CD  1 
ATOM   3580 N N   . ILE B 1 188 ? 39.995  -60.602 20.695  1.00 73.39  ?  182 ILE B N   1 
ATOM   3581 C CA  . ILE B 1 188 ? 41.002  -61.216 19.848  1.00 69.18  ?  182 ILE B CA  1 
ATOM   3582 C C   . ILE B 1 188 ? 41.666  -60.190 18.937  1.00 73.32  ?  182 ILE B C   1 
ATOM   3583 O O   . ILE B 1 188 ? 42.324  -60.554 17.973  1.00 76.28  ?  182 ILE B O   1 
ATOM   3584 C CB  . ILE B 1 188 ? 40.398  -62.376 19.043  1.00 71.51  ?  182 ILE B CB  1 
ATOM   3585 C CG1 . ILE B 1 188 ? 39.243  -61.873 18.175  1.00 71.25  ?  182 ILE B CG1 1 
ATOM   3586 C CG2 . ILE B 1 188 ? 39.921  -63.436 19.981  1.00 70.15  ?  182 ILE B CG2 1 
ATOM   3587 C CD1 . ILE B 1 188 ? 38.961  -62.763 17.014  1.00 69.73  ?  182 ILE B CD1 1 
ATOM   3588 N N   . GLY B 1 189 ? 41.495  -58.909 19.233  1.00 71.40  ?  183 GLY B N   1 
ATOM   3589 C CA  . GLY B 1 189 ? 42.180  -57.876 18.492  1.00 67.73  ?  183 GLY B CA  1 
ATOM   3590 C C   . GLY B 1 189 ? 41.257  -57.142 17.533  1.00 73.10  ?  183 GLY B C   1 
ATOM   3591 O O   . GLY B 1 189 ? 40.187  -57.624 17.147  1.00 72.33  ?  183 GLY B O   1 
ATOM   3592 N N   . THR B 1 190 ? 41.687  -55.935 17.173  1.00 68.82  ?  184 THR B N   1 
ATOM   3593 C CA  . THR B 1 190 ? 41.051  -55.072 16.184  1.00 69.57  ?  184 THR B CA  1 
ATOM   3594 C C   . THR B 1 190 ? 39.526  -55.107 16.232  1.00 70.84  ?  184 THR B C   1 
ATOM   3595 O O   . THR B 1 190 ? 38.854  -55.190 15.198  1.00 72.59  ?  184 THR B O   1 
ATOM   3596 C CB  . THR B 1 190 ? 41.603  -55.411 14.796  1.00 72.56  ?  184 THR B CB  1 
ATOM   3597 O OG1 . THR B 1 190 ? 41.284  -56.760 14.441  1.00 67.62  ?  184 THR B OG1 1 
ATOM   3598 C CG2 . THR B 1 190 ? 43.151  -55.265 14.829  1.00 74.41  ?  184 THR B CG2 1 
ATOM   3599 N N   . GLY B 1 191 ? 38.975  -55.010 17.440  1.00 66.03  ?  185 GLY B N   1 
ATOM   3600 C CA  . GLY B 1 191 ? 37.558  -54.905 17.611  1.00 64.89  ?  185 GLY B CA  1 
ATOM   3601 C C   . GLY B 1 191 ? 36.808  -56.213 17.577  1.00 70.88  ?  185 GLY B C   1 
ATOM   3602 O O   . GLY B 1 191 ? 35.606  -56.214 17.860  1.00 72.35  ?  185 GLY B O   1 
ATOM   3603 N N   . LEU B 1 192 ? 37.459  -57.328 17.255  1.00 69.87  ?  186 LEU B N   1 
ATOM   3604 C CA  . LEU B 1 192 ? 36.746  -58.595 17.159  1.00 71.81  ?  186 LEU B CA  1 
ATOM   3605 C C   . LEU B 1 192 ? 36.854  -59.380 18.464  1.00 72.40  ?  186 LEU B C   1 
ATOM   3606 O O   . LEU B 1 192 ? 37.745  -59.156 19.286  1.00 72.91  ?  186 LEU B O   1 
ATOM   3607 C CB  . LEU B 1 192 ? 37.272  -59.437 15.999  1.00 68.68  ?  186 LEU B CB  1 
ATOM   3608 C CG  . LEU B 1 192 ? 37.412  -58.683 14.681  1.00 70.48  ?  186 LEU B CG  1 
ATOM   3609 C CD1 . LEU B 1 192 ? 38.608  -59.185 13.867  1.00 69.28  ?  186 LEU B CD1 1 
ATOM   3610 C CD2 . LEU B 1 192 ? 36.144  -58.753 13.887  1.00 64.25  ?  186 LEU B CD2 1 
ATOM   3611 N N   . HIS B 1 193 ? 35.925  -60.314 18.647  1.00 71.47  ?  187 HIS B N   1 
ATOM   3612 C CA  . HIS B 1 193 ? 35.852  -61.051 19.898  1.00 75.18  ?  187 HIS B CA  1 
ATOM   3613 C C   . HIS B 1 193 ? 35.483  -62.510 19.634  1.00 79.36  ?  187 HIS B C   1 
ATOM   3614 O O   . HIS B 1 193 ? 34.843  -62.835 18.629  1.00 82.84  ?  187 HIS B O   1 
ATOM   3615 C CB  . HIS B 1 193 ? 34.863  -60.361 20.861  1.00 71.67  ?  187 HIS B CB  1 
ATOM   3616 C CG  . HIS B 1 193 ? 35.234  -58.937 21.177  1.00 80.12  ?  187 HIS B CG  1 
ATOM   3617 N ND1 . HIS B 1 193 ? 34.875  -57.872 20.374  1.00 79.45  ?  187 HIS B ND1 1 
ATOM   3618 C CD2 . HIS B 1 193 ? 35.963  -58.406 22.192  1.00 79.56  ?  187 HIS B CD2 1 
ATOM   3619 C CE1 . HIS B 1 193 ? 35.357  -56.750 20.885  1.00 73.25  ?  187 HIS B CE1 1 
ATOM   3620 N NE2 . HIS B 1 193 ? 36.016  -57.043 21.992  1.00 72.09  ?  187 HIS B NE2 1 
ATOM   3621 N N   . ARG B 1 194 ? 35.942  -63.395 20.521  1.00 74.97  ?  188 ARG B N   1 
ATOM   3622 C CA  . ARG B 1 194 ? 35.518  -64.788 20.553  1.00 76.30  ?  188 ARG B CA  1 
ATOM   3623 C C   . ARG B 1 194 ? 34.649  -65.010 21.781  1.00 76.86  ?  188 ARG B C   1 
ATOM   3624 O O   . ARG B 1 194 ? 34.821  -64.344 22.805  1.00 80.15  ?  188 ARG B O   1 
ATOM   3625 C CB  . ARG B 1 194 ? 36.717  -65.752 20.584  1.00 77.16  ?  188 ARG B CB  1 
ATOM   3626 C CG  . ARG B 1 194 ? 37.569  -65.648 21.861  1.00 76.27  ?  188 ARG B CG  1 
ATOM   3627 C CD  . ARG B 1 194 ? 38.708  -66.690 21.948  1.00 76.15  ?  188 ARG B CD  1 
ATOM   3628 N NE  . ARG B 1 194 ? 39.642  -66.624 20.827  1.00 74.23  ?  188 ARG B NE  1 
ATOM   3629 C CZ  . ARG B 1 194 ? 40.961  -66.525 20.941  1.00 69.96  ?  188 ARG B CZ  1 
ATOM   3630 N NH1 . ARG B 1 194 ? 41.553  -66.441 22.120  1.00 67.31  ?  188 ARG B NH1 1 
ATOM   3631 N NH2 . ARG B 1 194 ? 41.706  -66.507 19.841  1.00 74.88  ?  188 ARG B NH2 1 
ATOM   3632 N N   . ARG B 1 195 ? 33.713  -65.948 21.670  1.00 81.24  ?  189 ARG B N   1 
ATOM   3633 C CA  . ARG B 1 195 ? 32.759  -66.254 22.735  1.00 83.31  ?  189 ARG B CA  1 
ATOM   3634 C C   . ARG B 1 195 ? 33.147  -67.542 23.450  1.00 81.62  ?  189 ARG B C   1 
ATOM   3635 O O   . ARG B 1 195 ? 33.378  -68.576 22.809  1.00 81.87  ?  189 ARG B O   1 
ATOM   3636 C CB  . ARG B 1 195 ? 31.342  -66.374 22.172  1.00 85.98  ?  189 ARG B CB  1 
ATOM   3637 C CG  . ARG B 1 195 ? 30.568  -65.064 22.189  1.00 94.41  ?  189 ARG B CG  1 
ATOM   3638 C CD  . ARG B 1 195 ? 30.804  -64.265 20.918  1.00 100.81 ?  189 ARG B CD  1 
ATOM   3639 N NE  . ARG B 1 195 ? 29.564  -63.709 20.381  1.00 114.74 ?  189 ARG B NE  1 
ATOM   3640 C CZ  . ARG B 1 195 ? 29.450  -62.515 19.810  1.00 114.09 ?  189 ARG B CZ  1 
ATOM   3641 N NH1 . ARG B 1 195 ? 30.489  -61.696 19.695  1.00 107.76 ?  189 ARG B NH1 1 
ATOM   3642 N NH2 . ARG B 1 195 ? 28.267  -62.140 19.324  1.00 110.71 ?  189 ARG B NH2 1 
ATOM   3643 N N   . MET B 1 196 ? 33.219  -67.484 24.773  1.00 76.79  ?  190 MET B N   1 
ATOM   3644 C CA  . MET B 1 196 ? 33.576  -68.654 25.565  1.00 76.59  ?  190 MET B CA  1 
ATOM   3645 C C   . MET B 1 196 ? 32.366  -69.041 26.399  1.00 81.72  ?  190 MET B C   1 
ATOM   3646 O O   . MET B 1 196 ? 31.856  -68.220 27.177  1.00 81.49  ?  190 MET B O   1 
ATOM   3647 C CB  . MET B 1 196 ? 34.777  -68.374 26.457  1.00 77.00  ?  190 MET B CB  1 
ATOM   3648 C CG  . MET B 1 196 ? 35.984  -67.901 25.672  1.00 83.91  ?  190 MET B CG  1 
ATOM   3649 S SD  . MET B 1 196 ? 37.170  -69.193 25.299  1.00 85.89  ?  190 MET B SD  1 
ATOM   3650 C CE  . MET B 1 196 ? 37.284  -70.002 26.899  1.00 78.80  ?  190 MET B CE  1 
ATOM   3651 N N   . VAL B 1 197 ? 31.883  -70.271 26.216  1.00 81.37  ?  191 VAL B N   1 
ATOM   3652 C CA  . VAL B 1 197 ? 30.675  -70.734 26.888  1.00 80.21  ?  191 VAL B CA  1 
ATOM   3653 C C   . VAL B 1 197 ? 31.042  -71.876 27.816  1.00 76.90  ?  191 VAL B C   1 
ATOM   3654 O O   . VAL B 1 197 ? 31.563  -72.905 27.373  1.00 76.24  ?  191 VAL B O   1 
ATOM   3655 C CB  . VAL B 1 197 ? 29.581  -71.156 25.900  1.00 81.81  ?  191 VAL B CB  1 
ATOM   3656 C CG1 . VAL B 1 197 ? 28.226  -70.760 26.462  1.00 81.20  ?  191 VAL B CG1 1 
ATOM   3657 C CG2 . VAL B 1 197 ? 29.806  -70.502 24.555  1.00 80.70  ?  191 VAL B CG2 1 
ATOM   3658 N N   . TYR B 1 198 ? 30.778  -71.679 29.099  1.00 76.87  ?  192 TYR B N   1 
ATOM   3659 C CA  . TYR B 1 198 ? 30.854  -72.714 30.114  1.00 81.74  ?  192 TYR B CA  1 
ATOM   3660 C C   . TYR B 1 198 ? 29.430  -73.066 30.505  1.00 83.63  ?  192 TYR B C   1 
ATOM   3661 O O   . TYR B 1 198 ? 28.608  -72.171 30.731  1.00 85.72  ?  192 TYR B O   1 
ATOM   3662 C CB  . TYR B 1 198 ? 31.642  -72.247 31.340  1.00 79.53  ?  192 TYR B CB  1 
ATOM   3663 C CG  . TYR B 1 198 ? 32.996  -71.674 31.003  1.00 80.39  ?  192 TYR B CG  1 
ATOM   3664 C CD1 . TYR B 1 198 ? 33.121  -70.370 30.536  1.00 72.56  ?  192 TYR B CD1 1 
ATOM   3665 C CD2 . TYR B 1 198 ? 34.150  -72.439 31.136  1.00 78.78  ?  192 TYR B CD2 1 
ATOM   3666 C CE1 . TYR B 1 198 ? 34.342  -69.847 30.209  1.00 73.28  ?  192 TYR B CE1 1 
ATOM   3667 C CE2 . TYR B 1 198 ? 35.389  -71.917 30.819  1.00 75.04  ?  192 TYR B CE2 1 
ATOM   3668 C CZ  . TYR B 1 198 ? 35.473  -70.615 30.355  1.00 80.69  ?  192 TYR B CZ  1 
ATOM   3669 O OH  . TYR B 1 198 ? 36.693  -70.072 30.036  1.00 85.49  ?  192 TYR B OH  1 
ATOM   3670 N N   . VAL B 1 199 ? 29.139  -74.361 30.572  1.00 88.21  ?  193 VAL B N   1 
ATOM   3671 C CA  . VAL B 1 199 ? 27.779  -74.839 30.777  1.00 92.47  ?  193 VAL B CA  1 
ATOM   3672 C C   . VAL B 1 199 ? 27.760  -75.873 31.894  1.00 96.75  ?  193 VAL B C   1 
ATOM   3673 O O   . VAL B 1 199 ? 28.720  -76.631 32.093  1.00 94.08  ?  193 VAL B O   1 
ATOM   3674 C CB  . VAL B 1 199 ? 27.196  -75.426 29.478  1.00 86.80  ?  193 VAL B CB  1 
ATOM   3675 C CG1 . VAL B 1 199 ? 26.983  -74.314 28.455  1.00 90.62  ?  193 VAL B CG1 1 
ATOM   3676 C CG2 . VAL B 1 199 ? 28.127  -76.485 28.924  1.00 82.05  ?  193 VAL B CG2 1 
ATOM   3677 N N   . GLU B 1 200 ? 26.654  -75.888 32.632  1.00 95.53  ?  194 GLU B N   1 
ATOM   3678 C CA  . GLU B 1 200 ? 26.447  -76.875 33.688  1.00 99.25  ?  194 GLU B CA  1 
ATOM   3679 C C   . GLU B 1 200 ? 25.791  -78.136 33.145  1.00 100.55 ?  194 GLU B C   1 
ATOM   3680 O O   . GLU B 1 200 ? 24.602  -78.123 32.837  1.00 103.58 ?  194 GLU B O   1 
ATOM   3681 C CB  . GLU B 1 200 ? 25.589  -76.285 34.798  1.00 97.63  ?  194 GLU B CB  1 
ATOM   3682 C CG  . GLU B 1 200 ? 25.995  -76.732 36.176  1.00 98.38  ?  194 GLU B CG  1 
ATOM   3683 C CD  . GLU B 1 200 ? 25.699  -75.680 37.215  1.00 102.87 ?  194 GLU B CD  1 
ATOM   3684 O OE1 . GLU B 1 200 ? 26.035  -74.500 36.957  1.00 97.20  ?  194 GLU B OE1 1 
ATOM   3685 O OE2 . GLU B 1 200 ? 25.128  -76.029 38.278  1.00 106.53 -1 194 GLU B OE2 1 
ATOM   3686 N N   . GLU B 1 212 ? 26.346  -81.088 24.145  1.00 103.86 ?  206 GLU B N   1 
ATOM   3687 C CA  . GLU B 1 212 ? 25.882  -81.332 22.786  1.00 110.25 ?  206 GLU B CA  1 
ATOM   3688 C C   . GLU B 1 212 ? 26.201  -80.158 21.839  1.00 117.89 ?  206 GLU B C   1 
ATOM   3689 O O   . GLU B 1 212 ? 26.511  -79.037 22.280  1.00 109.01 ?  206 GLU B O   1 
ATOM   3690 C CB  . GLU B 1 212 ? 24.382  -81.621 22.797  1.00 109.92 ?  206 GLU B CB  1 
ATOM   3691 C CG  . GLU B 1 212 ? 23.870  -82.311 21.548  1.00 115.82 ?  206 GLU B CG  1 
ATOM   3692 C CD  . GLU B 1 212 ? 22.625  -83.146 21.796  1.00 117.62 ?  206 GLU B CD  1 
ATOM   3693 O OE1 . GLU B 1 212 ? 22.768  -84.347 22.121  1.00 110.67 ?  206 GLU B OE1 1 
ATOM   3694 O OE2 . GLU B 1 212 ? 21.507  -82.595 21.672  1.00 117.57 ?  206 GLU B OE2 1 
ATOM   3695 N N   . ARG B 1 213 ? 26.096  -80.437 20.532  1.00 119.58 ?  207 ARG B N   1 
ATOM   3696 C CA  . ARG B 1 213 ? 26.643  -79.560 19.496  1.00 115.56 ?  207 ARG B CA  1 
ATOM   3697 C C   . ARG B 1 213 ? 25.932  -78.215 19.419  1.00 114.86 ?  207 ARG B C   1 
ATOM   3698 O O   . ARG B 1 213 ? 26.530  -77.231 18.968  1.00 113.99 ?  207 ARG B O   1 
ATOM   3699 C CB  . ARG B 1 213 ? 26.567  -80.255 18.136  1.00 114.00 ?  207 ARG B CB  1 
ATOM   3700 C CG  . ARG B 1 213 ? 27.216  -79.494 17.000  1.00 114.90 ?  207 ARG B CG  1 
ATOM   3701 C CD  . ARG B 1 213 ? 28.594  -78.997 17.403  1.00 123.93 ?  207 ARG B CD  1 
ATOM   3702 N NE  . ARG B 1 213 ? 29.389  -78.475 16.294  1.00 127.27 ?  207 ARG B NE  1 
ATOM   3703 C CZ  . ARG B 1 213 ? 29.700  -79.141 15.189  1.00 127.66 ?  207 ARG B CZ  1 
ATOM   3704 N NH1 . ARG B 1 213 ? 29.326  -80.398 15.004  1.00 127.45 ?  207 ARG B NH1 1 
ATOM   3705 N NH2 . ARG B 1 213 ? 30.420  -78.534 14.249  1.00 128.10 ?  207 ARG B NH2 1 
ATOM   3706 N N   . ILE B 1 214 ? 24.667  -78.151 19.829  1.00 114.98 ?  208 ILE B N   1 
ATOM   3707 C CA  . ILE B 1 214 ? 23.887  -76.930 19.671  1.00 111.90 ?  208 ILE B CA  1 
ATOM   3708 C C   . ILE B 1 214 ? 24.640  -75.748 20.265  1.00 116.27 ?  208 ILE B C   1 
ATOM   3709 O O   . ILE B 1 214 ? 25.054  -75.766 21.431  1.00 111.41 ?  208 ILE B O   1 
ATOM   3710 C CB  . ILE B 1 214 ? 22.484  -77.063 20.287  1.00 113.01 ?  208 ILE B CB  1 
ATOM   3711 C CG1 . ILE B 1 214 ? 21.871  -78.413 19.914  1.00 108.44 ?  208 ILE B CG1 1 
ATOM   3712 C CG2 . ILE B 1 214 ? 21.600  -75.897 19.833  1.00 109.51 ?  208 ILE B CG2 1 
ATOM   3713 C CD1 . ILE B 1 214 ? 21.999  -79.457 20.979  1.00 107.92 ?  208 ILE B CD1 1 
ATOM   3714 N N   . LEU B 1 215 ? 24.859  -74.736 19.421  1.00 120.11 ?  209 LEU B N   1 
ATOM   3715 C CA  . LEU B 1 215 ? 25.517  -73.496 19.815  1.00 111.24 ?  209 LEU B CA  1 
ATOM   3716 C C   . LEU B 1 215 ? 24.993  -72.325 18.990  1.00 113.03 ?  209 LEU B C   1 
ATOM   3717 O O   . LEU B 1 215 ? 25.604  -71.249 19.022  1.00 110.35 ?  209 LEU B O   1 
ATOM   3718 C CB  . LEU B 1 215 ? 27.042  -73.611 19.637  1.00 108.76 ?  209 LEU B CB  1 
ATOM   3719 C CG  . LEU B 1 215 ? 27.575  -74.089 18.275  1.00 107.90 ?  209 LEU B CG  1 
ATOM   3720 C CD1 . LEU B 1 215 ? 27.741  -72.952 17.269  1.00 106.83 ?  209 LEU B CD1 1 
ATOM   3721 C CD2 . LEU B 1 215 ? 28.890  -74.817 18.450  1.00 103.95 ?  209 LEU B CD2 1 
ATOM   3722 N N   . GLN B 1 216 ? 23.903  -72.505 18.240  1.00 116.20 ?  210 GLN B N   1 
ATOM   3723 C CA  . GLN B 1 216 ? 23.476  -71.559 17.217  1.00 114.38 ?  210 GLN B CA  1 
ATOM   3724 C C   . GLN B 1 216 ? 22.456  -70.578 17.776  1.00 111.98 ?  210 GLN B C   1 
ATOM   3725 O O   . GLN B 1 216 ? 21.558  -70.955 18.534  1.00 110.85 ?  210 GLN B O   1 
ATOM   3726 C CB  . GLN B 1 216 ? 22.875  -72.300 16.019  1.00 108.90 ?  210 GLN B CB  1 
ATOM   3727 C CG  . GLN B 1 216 ? 23.894  -73.005 15.136  1.00 108.30 ?  210 GLN B CG  1 
ATOM   3728 C CD  . GLN B 1 216 ? 24.383  -74.316 15.722  1.00 111.35 ?  210 GLN B CD  1 
ATOM   3729 O OE1 . GLN B 1 216 ? 23.673  -74.975 16.484  1.00 116.33 ?  210 GLN B OE1 1 
ATOM   3730 N NE2 . GLN B 1 216 ? 25.604  -74.703 15.367  1.00 108.87 ?  210 GLN B NE2 1 
ATOM   3731 N N   . ASP B 1 217 ? 22.595  -69.320 17.380  1.00 109.96 ?  211 ASP B N   1 
ATOM   3732 C CA  . ASP B 1 217 ? 21.699  -68.269 17.833  1.00 113.66 ?  211 ASP B CA  1 
ATOM   3733 C C   . ASP B 1 217 ? 21.938  -66.983 17.051  1.00 112.46 ?  211 ASP B C   1 
ATOM   3734 O O   . ASP B 1 217 ? 23.044  -66.439 17.065  1.00 112.96 ?  211 ASP B O   1 
ATOM   3735 C CB  . ASP B 1 217 ? 21.881  -68.012 19.327  1.00 111.76 ?  211 ASP B CB  1 
ATOM   3736 C CG  . ASP B 1 217 ? 21.493  -66.604 19.717  1.00 116.25 ?  211 ASP B CG  1 
ATOM   3737 O OD1 . ASP B 1 217 ? 20.301  -66.382 20.008  1.00 120.26 -1 211 ASP B OD1 1 
ATOM   3738 O OD2 . ASP B 1 217 ? 22.378  -65.716 19.717  1.00 109.77 ?  211 ASP B OD2 1 
ATOM   3739 N N   . ASP B 1 223 ? 29.761  -66.090 15.193  1.00 105.67 ?  217 ASP B N   1 
ATOM   3740 C CA  . ASP B 1 223 ? 31.059  -65.699 15.752  1.00 101.82 ?  217 ASP B CA  1 
ATOM   3741 C C   . ASP B 1 223 ? 31.862  -66.901 16.225  1.00 94.91  ?  217 ASP B C   1 
ATOM   3742 O O   . ASP B 1 223 ? 31.294  -67.956 16.521  1.00 93.49  ?  217 ASP B O   1 
ATOM   3743 C CB  . ASP B 1 223 ? 30.878  -64.726 16.917  1.00 102.78 ?  217 ASP B CB  1 
ATOM   3744 C CG  . ASP B 1 223 ? 30.268  -63.416 16.483  1.00 113.15 ?  217 ASP B CG  1 
ATOM   3745 O OD1 . ASP B 1 223 ? 29.609  -63.412 15.414  1.00 117.35 ?  217 ASP B OD1 1 
ATOM   3746 O OD2 . ASP B 1 223 ? 30.455  -62.399 17.196  1.00 110.54 -1 217 ASP B OD2 1 
ATOM   3747 N N   . GLU B 1 224 ? 33.185  -66.735 16.291  1.00 93.34  ?  218 GLU B N   1 
ATOM   3748 C CA  . GLU B 1 224 ? 34.047  -67.781 16.832  1.00 86.79  ?  218 GLU B CA  1 
ATOM   3749 C C   . GLU B 1 224 ? 33.633  -68.088 18.264  1.00 84.39  ?  218 GLU B C   1 
ATOM   3750 O O   . GLU B 1 224 ? 33.622  -67.203 19.124  1.00 84.75  ?  218 GLU B O   1 
ATOM   3751 C CB  . GLU B 1 224 ? 35.507  -67.347 16.771  1.00 76.55  ?  218 GLU B CB  1 
ATOM   3752 C CG  . GLU B 1 224 ? 36.466  -68.238 17.519  1.00 75.77  ?  218 GLU B CG  1 
ATOM   3753 C CD  . GLU B 1 224 ? 37.848  -67.602 17.652  1.00 82.73  ?  218 GLU B CD  1 
ATOM   3754 O OE1 . GLU B 1 224 ? 38.182  -66.707 16.833  1.00 81.08  ?  218 GLU B OE1 1 
ATOM   3755 O OE2 . GLU B 1 224 ? 38.602  -67.994 18.574  1.00 78.21  -1 218 GLU B OE2 1 
ATOM   3756 N N   . THR B 1 225 ? 33.259  -69.334 18.512  1.00 81.80  ?  219 THR B N   1 
ATOM   3757 C CA  . THR B 1 225 ? 32.700  -69.710 19.796  1.00 81.66  ?  219 THR B CA  1 
ATOM   3758 C C   . THR B 1 225 ? 33.323  -71.015 20.258  1.00 78.36  ?  219 THR B C   1 
ATOM   3759 O O   . THR B 1 225 ? 33.663  -71.876 19.444  1.00 84.65  ?  219 THR B O   1 
ATOM   3760 C CB  . THR B 1 225 ? 31.177  -69.815 19.700  1.00 82.19  ?  219 THR B CB  1 
ATOM   3761 O OG1 . THR B 1 225 ? 30.659  -68.559 19.240  1.00 79.09  ?  219 THR B OG1 1 
ATOM   3762 C CG2 . THR B 1 225 ? 30.565  -70.158 21.059  1.00 78.44  ?  219 THR B CG2 1 
ATOM   3763 N N   . HIS B 1 226 ? 33.522  -71.128 21.561  1.00 76.83  ?  220 HIS B N   1 
ATOM   3764 C CA  . HIS B 1 226 ? 34.038  -72.335 22.176  1.00 71.06  ?  220 HIS B CA  1 
ATOM   3765 C C   . HIS B 1 226 ? 33.097  -72.695 23.311  1.00 79.58  ?  220 HIS B C   1 
ATOM   3766 O O   . HIS B 1 226 ? 32.543  -71.805 23.964  1.00 82.93  ?  220 HIS B O   1 
ATOM   3767 C CB  . HIS B 1 226 ? 35.459  -72.135 22.703  1.00 72.99  ?  220 HIS B CB  1 
ATOM   3768 C CG  . HIS B 1 226 ? 36.442  -71.702 21.661  1.00 74.55  ?  220 HIS B CG  1 
ATOM   3769 N ND1 . HIS B 1 226 ? 37.445  -72.525 21.195  1.00 77.40  ?  220 HIS B ND1 1 
ATOM   3770 C CD2 . HIS B 1 226 ? 36.600  -70.520 21.017  1.00 79.72  ?  220 HIS B CD2 1 
ATOM   3771 C CE1 . HIS B 1 226 ? 38.167  -71.878 20.296  1.00 72.26  ?  220 HIS B CE1 1 
ATOM   3772 N NE2 . HIS B 1 226 ? 37.674  -70.659 20.167  1.00 79.44  ?  220 HIS B NE2 1 
ATOM   3773 N N   . VAL B 1 227 ? 32.892  -73.993 23.537  1.00 83.15  ?  221 VAL B N   1 
ATOM   3774 C CA  . VAL B 1 227 ? 31.977  -74.463 24.572  1.00 82.51  ?  221 VAL B CA  1 
ATOM   3775 C C   . VAL B 1 227 ? 32.701  -75.495 25.418  1.00 84.68  ?  221 VAL B C   1 
ATOM   3776 O O   . VAL B 1 227 ? 33.346  -76.402 24.881  1.00 81.21  ?  221 VAL B O   1 
ATOM   3777 C CB  . VAL B 1 227 ? 30.679  -75.058 23.991  1.00 84.48  ?  221 VAL B CB  1 
ATOM   3778 C CG1 . VAL B 1 227 ? 29.831  -75.635 25.111  1.00 82.57  ?  221 VAL B CG1 1 
ATOM   3779 C CG2 . VAL B 1 227 ? 29.890  -73.993 23.221  1.00 82.86  ?  221 VAL B CG2 1 
ATOM   3780 N N   . LEU B 1 228 ? 32.601  -75.347 26.737  1.00 88.07  ?  222 LEU B N   1 
ATOM   3781 C CA  . LEU B 1 228 ? 33.195  -76.261 27.703  1.00 89.28  ?  222 LEU B CA  1 
ATOM   3782 C C   . LEU B 1 228 ? 32.154  -76.565 28.775  1.00 90.23  ?  222 LEU B C   1 
ATOM   3783 O O   . LEU B 1 228 ? 31.323  -75.712 29.105  1.00 89.10  ?  222 LEU B O   1 
ATOM   3784 C CB  . LEU B 1 228 ? 34.477  -75.654 28.329  1.00 86.79  ?  222 LEU B CB  1 
ATOM   3785 C CG  . LEU B 1 228 ? 35.535  -76.608 28.902  1.00 88.07  ?  222 LEU B CG  1 
ATOM   3786 C CD1 . LEU B 1 228 ? 36.920  -76.125 28.545  1.00 87.64  ?  222 LEU B CD1 1 
ATOM   3787 C CD2 . LEU B 1 228 ? 35.404  -76.745 30.408  1.00 89.40  ?  222 LEU B CD2 1 
ATOM   3788 N N   . GLN B 1 229 ? 32.172  -77.791 29.299  1.00 90.72  ?  223 GLN B N   1 
ATOM   3789 C CA  . GLN B 1 229 ? 31.267  -78.140 30.387  1.00 94.38  ?  223 GLN B CA  1 
ATOM   3790 C C   . GLN B 1 229 ? 32.020  -78.060 31.703  1.00 95.33  ?  223 GLN B C   1 
ATOM   3791 O O   . GLN B 1 229 ? 33.198  -78.430 31.785  1.00 88.24  ?  223 GLN B O   1 
ATOM   3792 C CB  . GLN B 1 229 ? 30.638  -79.531 30.239  1.00 98.45  ?  223 GLN B CB  1 
ATOM   3793 C CG  . GLN B 1 229 ? 29.321  -79.654 31.046  1.00 103.46 ?  223 GLN B CG  1 
ATOM   3794 C CD  . GLN B 1 229 ? 28.922  -81.087 31.413  1.00 106.94 ?  223 GLN B CD  1 
ATOM   3795 O OE1 . GLN B 1 229 ? 29.773  -81.971 31.563  1.00 106.06 ?  223 GLN B OE1 1 
ATOM   3796 N NE2 . GLN B 1 229 ? 27.617  -81.309 31.583  1.00 99.79  ?  223 GLN B NE2 1 
ATOM   3797 N N   . VAL B 1 230 ? 31.332  -77.549 32.724  1.00 93.07  ?  224 VAL B N   1 
ATOM   3798 C CA  . VAL B 1 230 ? 31.906  -77.336 34.043  1.00 93.32  ?  224 VAL B CA  1 
ATOM   3799 C C   . VAL B 1 230 ? 30.879  -77.806 35.060  1.00 91.88  ?  224 VAL B C   1 
ATOM   3800 O O   . VAL B 1 230 ? 29.680  -77.882 34.776  1.00 92.49  ?  224 VAL B O   1 
ATOM   3801 C CB  . VAL B 1 230 ? 32.288  -75.854 34.295  1.00 87.86  ?  224 VAL B CB  1 
ATOM   3802 C CG1 . VAL B 1 230 ? 33.227  -75.342 33.210  1.00 81.88  ?  224 VAL B CG1 1 
ATOM   3803 C CG2 . VAL B 1 230 ? 31.045  -74.982 34.375  1.00 85.24  ?  224 VAL B CG2 1 
ATOM   3804 N N   . ASP B 1 231 ? 31.364  -78.123 36.262  1.00 92.22  ?  225 ASP B N   1 
ATOM   3805 C CA  . ASP B 1 231 ? 30.452  -78.596 37.295  1.00 92.30  ?  225 ASP B CA  1 
ATOM   3806 C C   . ASP B 1 231 ? 29.685  -77.442 37.926  1.00 91.19  ?  225 ASP B C   1 
ATOM   3807 O O   . ASP B 1 231 ? 28.481  -77.570 38.187  1.00 90.15  ?  225 ASP B O   1 
ATOM   3808 C CB  . ASP B 1 231 ? 31.218  -79.392 38.356  1.00 93.48  ?  225 ASP B CB  1 
ATOM   3809 C CG  . ASP B 1 231 ? 31.695  -80.749 37.841  1.00 100.83 ?  225 ASP B CG  1 
ATOM   3810 O OD1 . ASP B 1 231 ? 30.890  -81.473 37.205  1.00 98.10  ?  225 ASP B OD1 1 
ATOM   3811 O OD2 . ASP B 1 231 ? 32.883  -81.084 38.060  1.00 98.51  -1 225 ASP B OD2 1 
ATOM   3812 N N   . ASP B 1 232 ? 30.348  -76.304 38.152  1.00 85.90  ?  226 ASP B N   1 
ATOM   3813 C CA  . ASP B 1 232 ? 29.745  -75.164 38.845  1.00 85.83  ?  226 ASP B CA  1 
ATOM   3814 C C   . ASP B 1 232 ? 30.068  -73.873 38.093  1.00 83.78  ?  226 ASP B C   1 
ATOM   3815 O O   . ASP B 1 232 ? 31.185  -73.350 38.182  1.00 83.66  ?  226 ASP B O   1 
ATOM   3816 C CB  . ASP B 1 232 ? 30.230  -75.099 40.293  1.00 81.74  ?  226 ASP B CB  1 
ATOM   3817 C CG  . ASP B 1 232 ? 29.406  -74.140 41.153  1.00 86.35  ?  226 ASP B CG  1 
ATOM   3818 O OD1 . ASP B 1 232 ? 28.592  -73.333 40.616  1.00 79.61  ?  226 ASP B OD1 1 
ATOM   3819 O OD2 . ASP B 1 232 ? 29.591  -74.200 42.390  1.00 89.86  -1 226 ASP B OD2 1 
ATOM   3820 N N   . VAL B 1 233 ? 29.079  -73.339 37.374  1.00 84.69  ?  227 VAL B N   1 
ATOM   3821 C CA  . VAL B 1 233 ? 29.300  -72.113 36.614  1.00 78.43  ?  227 VAL B CA  1 
ATOM   3822 C C   . VAL B 1 233 ? 29.502  -70.916 37.544  1.00 77.92  ?  227 VAL B C   1 
ATOM   3823 O O   . VAL B 1 233 ? 30.264  -69.999 37.220  1.00 75.63  ?  227 VAL B O   1 
ATOM   3824 C CB  . VAL B 1 233 ? 28.137  -71.902 35.627  1.00 79.93  ?  227 VAL B CB  1 
ATOM   3825 C CG1 . VAL B 1 233 ? 27.818  -70.429 35.448  1.00 85.18  ?  227 VAL B CG1 1 
ATOM   3826 C CG2 . VAL B 1 233 ? 28.475  -72.528 34.298  1.00 81.99  ?  227 VAL B CG2 1 
ATOM   3827 N N   . LYS B 1 234 ? 28.861  -70.913 38.719  1.00 78.42  ?  228 LYS B N   1 
ATOM   3828 C CA  . LYS B 1 234 ? 29.029  -69.807 39.660  1.00 75.94  ?  228 LYS B CA  1 
ATOM   3829 C C   . LYS B 1 234 ? 30.476  -69.642 40.125  1.00 76.87  ?  228 LYS B C   1 
ATOM   3830 O O   . LYS B 1 234 ? 30.883  -68.528 40.470  1.00 76.35  ?  228 LYS B O   1 
ATOM   3831 C CB  . LYS B 1 234 ? 28.120  -70.001 40.869  1.00 79.21  ?  228 LYS B CB  1 
ATOM   3832 C CG  . LYS B 1 234 ? 26.631  -69.916 40.555  1.00 91.27  ?  228 LYS B CG  1 
ATOM   3833 C CD  . LYS B 1 234 ? 25.786  -70.557 41.662  1.00 94.16  ?  228 LYS B CD  1 
ATOM   3834 C CE  . LYS B 1 234 ? 24.447  -69.861 41.817  1.00 97.30  ?  228 LYS B CE  1 
ATOM   3835 N NZ  . LYS B 1 234 ? 23.914  -70.000 43.201  1.00 103.15 ?  228 LYS B NZ  1 
ATOM   3836 N N   . GLN B 1 235 ? 31.268  -70.722 40.151  1.00 75.00  ?  229 GLN B N   1 
ATOM   3837 C CA  . GLN B 1 235 ? 32.657  -70.601 40.582  1.00 71.79  ?  229 GLN B CA  1 
ATOM   3838 C C   . GLN B 1 235 ? 33.519  -69.782 39.626  1.00 71.15  ?  229 GLN B C   1 
ATOM   3839 O O   . GLN B 1 235 ? 34.632  -69.385 39.998  1.00 66.94  ?  229 GLN B O   1 
ATOM   3840 C CB  . GLN B 1 235 ? 33.276  -71.975 40.755  1.00 66.60  ?  229 GLN B CB  1 
ATOM   3841 C CG  . GLN B 1 235 ? 32.863  -72.633 42.033  1.00 73.68  ?  229 GLN B CG  1 
ATOM   3842 C CD  . GLN B 1 235 ? 33.588  -72.077 43.226  1.00 73.69  ?  229 GLN B CD  1 
ATOM   3843 O OE1 . GLN B 1 235 ? 34.610  -71.405 43.086  1.00 78.77  ?  229 GLN B OE1 1 
ATOM   3844 N NE2 . GLN B 1 235 ? 33.060  -72.337 44.415  1.00 75.04  ?  229 GLN B NE2 1 
ATOM   3845 N N   . LEU B 1 236 ? 33.038  -69.511 38.428  1.00 63.36  ?  230 LEU B N   1 
ATOM   3846 C CA  . LEU B 1 236 ? 33.810  -68.795 37.437  1.00 64.34  ?  230 LEU B CA  1 
ATOM   3847 C C   . LEU B 1 236 ? 33.524  -67.300 37.441  1.00 70.53  ?  230 LEU B C   1 
ATOM   3848 O O   . LEU B 1 236 ? 34.191  -66.552 36.716  1.00 72.58  ?  230 LEU B O   1 
ATOM   3849 C CB  . LEU B 1 236 ? 33.521  -69.391 36.057  1.00 64.39  ?  230 LEU B CB  1 
ATOM   3850 C CG  . LEU B 1 236 ? 34.349  -70.633 35.703  1.00 70.37  ?  230 LEU B CG  1 
ATOM   3851 C CD1 . LEU B 1 236 ? 34.181  -71.758 36.705  1.00 69.01  ?  230 LEU B CD1 1 
ATOM   3852 C CD2 . LEU B 1 236 ? 33.958  -71.117 34.349  1.00 74.57  ?  230 LEU B CD2 1 
ATOM   3853 N N   . ILE B 1 237 ? 32.586  -66.837 38.258  1.00 64.69  ?  231 ILE B N   1 
ATOM   3854 C CA  . ILE B 1 237 ? 32.084  -65.475 38.128  1.00 65.41  ?  231 ILE B CA  1 
ATOM   3855 C C   . ILE B 1 237 ? 33.048  -64.489 38.778  1.00 65.04  ?  231 ILE B C   1 
ATOM   3856 O O   . ILE B 1 237 ? 33.418  -64.639 39.946  1.00 66.09  ?  231 ILE B O   1 
ATOM   3857 C CB  . ILE B 1 237 ? 30.676  -65.359 38.731  1.00 68.14  ?  231 ILE B CB  1 
ATOM   3858 C CG1 . ILE B 1 237 ? 29.739  -66.367 38.067  1.00 74.65  ?  231 ILE B CG1 1 
ATOM   3859 C CG2 . ILE B 1 237 ? 30.125  -63.960 38.552  1.00 58.41  ?  231 ILE B CG2 1 
ATOM   3860 C CD1 . ILE B 1 237 ? 29.310  -65.944 36.700  1.00 74.41  ?  231 ILE B CD1 1 
ATOM   3861 N N   . ASP B 1 238 ? 33.447  -63.467 38.019  1.00 62.30  ?  232 ASP B N   1 
ATOM   3862 C CA  . ASP B 1 238 ? 34.137  -62.301 38.544  1.00 55.85  ?  232 ASP B CA  1 
ATOM   3863 C C   . ASP B 1 238 ? 33.642  -61.102 37.764  1.00 58.42  ?  232 ASP B C   1 
ATOM   3864 O O   . ASP B 1 238 ? 33.521  -61.147 36.539  1.00 67.08  ?  232 ASP B O   1 
ATOM   3865 C CB  . ASP B 1 238 ? 35.675  -62.397 38.435  1.00 60.17  ?  232 ASP B CB  1 
ATOM   3866 C CG  . ASP B 1 238 ? 36.389  -61.083 38.852  1.00 64.98  ?  232 ASP B CG  1 
ATOM   3867 O OD1 . ASP B 1 238 ? 36.399  -60.736 40.069  1.00 58.20  ?  232 ASP B OD1 1 
ATOM   3868 O OD2 . ASP B 1 238 ? 36.915  -60.378 37.949  1.00 64.65  -1 232 ASP B OD2 1 
ATOM   3869 N N   . ARG B 1 239 ? 33.370  -60.025 38.479  1.00 57.19  ?  233 ARG B N   1 
ATOM   3870 C CA  . ARG B 1 239 ? 32.644  -58.894 37.922  1.00 63.70  ?  233 ARG B CA  1 
ATOM   3871 C C   . ARG B 1 239 ? 33.602  -57.761 37.516  1.00 65.06  ?  233 ARG B C   1 
ATOM   3872 O O   . ARG B 1 239 ? 33.176  -56.618 37.309  1.00 62.29  ?  233 ARG B O   1 
ATOM   3873 C CB  . ARG B 1 239 ? 31.581  -58.484 38.954  1.00 58.42  ?  233 ARG B CB  1 
ATOM   3874 C CG  . ARG B 1 239 ? 30.367  -57.660 38.564  1.00 69.93  ?  233 ARG B CG  1 
ATOM   3875 C CD  . ARG B 1 239 ? 29.595  -57.930 37.242  1.00 75.37  ?  233 ARG B CD  1 
ATOM   3876 N NE  . ARG B 1 239 ? 28.630  -56.845 36.982  1.00 60.94  ?  233 ARG B NE  1 
ATOM   3877 C CZ  . ARG B 1 239 ? 28.514  -56.203 35.829  1.00 60.60  ?  233 ARG B CZ  1 
ATOM   3878 N NH1 . ARG B 1 239 ? 29.221  -56.569 34.776  1.00 68.40  ?  233 ARG B NH1 1 
ATOM   3879 N NH2 . ARG B 1 239 ? 27.671  -55.165 35.729  1.00 56.66  ?  233 ARG B NH2 1 
ATOM   3880 N N   . GLY B 1 240 ? 34.909  -58.073 37.374  1.00 59.05  ?  234 GLY B N   1 
ATOM   3881 C CA  . GLY B 1 240 ? 35.843  -57.126 36.809  1.00 59.52  ?  234 GLY B CA  1 
ATOM   3882 C C   . GLY B 1 240 ? 36.044  -57.314 35.318  1.00 58.91  ?  234 GLY B C   1 
ATOM   3883 O O   . GLY B 1 240 ? 35.760  -58.368 34.753  1.00 59.98  ?  234 GLY B O   1 
ATOM   3884 N N   . ILE B 1 241 ? 36.561  -56.277 34.667  1.00 57.11  ?  235 ILE B N   1 
ATOM   3885 C CA  . ILE B 1 241 ? 36.685  -56.290 33.217  1.00 57.88  ?  235 ILE B CA  1 
ATOM   3886 C C   . ILE B 1 241 ? 37.806  -55.346 32.808  1.00 60.84  ?  235 ILE B C   1 
ATOM   3887 O O   . ILE B 1 241 ? 38.100  -54.363 33.496  1.00 62.06  ?  235 ILE B O   1 
ATOM   3888 C CB  . ILE B 1 241 ? 35.336  -55.918 32.552  1.00 63.95  ?  235 ILE B CB  1 
ATOM   3889 C CG1 . ILE B 1 241 ? 35.316  -56.317 31.080  1.00 67.97  ?  235 ILE B CG1 1 
ATOM   3890 C CG2 . ILE B 1 241 ? 35.001  -54.441 32.741  1.00 60.69  ?  235 ILE B CG2 1 
ATOM   3891 C CD1 . ILE B 1 241 ? 33.903  -56.453 30.521  1.00 70.05  ?  235 ILE B CD1 1 
ATOM   3892 N N   . GLY B 1 242 ? 38.469  -55.678 31.703  1.00 60.60  ?  236 GLY B N   1 
ATOM   3893 C CA  . GLY B 1 242 ? 39.493  -54.832 31.124  1.00 57.13  ?  236 GLY B CA  1 
ATOM   3894 C C   . GLY B 1 242 ? 38.927  -54.241 29.848  1.00 65.21  ?  236 GLY B C   1 
ATOM   3895 O O   . GLY B 1 242 ? 38.076  -54.855 29.199  1.00 62.43  ?  236 GLY B O   1 
ATOM   3896 N N   . VAL B 1 243 ? 39.364  -53.030 29.502  1.00 54.15  ?  237 VAL B N   1 
ATOM   3897 C CA  . VAL B 1 243 ? 38.948  -52.421 28.248  1.00 56.61  ?  237 VAL B CA  1 
ATOM   3898 C C   . VAL B 1 243 ? 40.173  -51.814 27.599  1.00 57.81  ?  237 VAL B C   1 
ATOM   3899 O O   . VAL B 1 243 ? 40.929  -51.082 28.250  1.00 62.11  ?  237 VAL B O   1 
ATOM   3900 C CB  . VAL B 1 243 ? 37.841  -51.367 28.462  1.00 63.13  ?  237 VAL B CB  1 
ATOM   3901 C CG1 . VAL B 1 243 ? 37.807  -50.369 27.334  1.00 66.88  ?  237 VAL B CG1 1 
ATOM   3902 C CG2 . VAL B 1 243 ? 36.495  -52.049 28.586  1.00 65.59  ?  237 VAL B CG2 1 
ATOM   3903 N N   . ARG B 1 244 ? 40.392  -52.124 26.328  1.00 59.15  ?  238 ARG B N   1 
ATOM   3904 C CA  . ARG B 1 244 ? 41.495  -51.514 25.588  1.00 66.79  ?  238 ARG B CA  1 
ATOM   3905 C C   . ARG B 1 244 ? 40.950  -50.769 24.381  1.00 63.40  ?  238 ARG B C   1 
ATOM   3906 O O   . ARG B 1 244 ? 40.357  -51.372 23.475  1.00 62.08  ?  238 ARG B O   1 
ATOM   3907 C CB  . ARG B 1 244 ? 42.551  -52.543 25.169  1.00 65.90  ?  238 ARG B CB  1 
ATOM   3908 C CG  . ARG B 1 244 ? 43.961  -51.959 25.138  1.00 66.57  ?  238 ARG B CG  1 
ATOM   3909 C CD  . ARG B 1 244 ? 44.964  -52.919 24.510  1.00 78.73  ?  238 ARG B CD  1 
ATOM   3910 N NE  . ARG B 1 244 ? 45.961  -52.226 23.701  1.00 79.88  ?  238 ARG B NE  1 
ATOM   3911 C CZ  . ARG B 1 244 ? 47.101  -51.730 24.166  1.00 81.25  ?  238 ARG B CZ  1 
ATOM   3912 N NH1 . ARG B 1 244 ? 47.444  -51.854 25.440  1.00 80.35  ?  238 ARG B NH1 1 
ATOM   3913 N NH2 . ARG B 1 244 ? 47.922  -51.100 23.327  1.00 82.29  ?  238 ARG B NH2 1 
ATOM   3914 N N   . MET B 1 245 ? 41.134  -49.457 24.399  1.00 59.74  ?  239 MET B N   1 
ATOM   3915 C CA  . MET B 1 245 ? 40.774  -48.555 23.316  1.00 63.69  ?  239 MET B CA  1 
ATOM   3916 C C   . MET B 1 245 ? 42.058  -48.081 22.652  1.00 64.04  ?  239 MET B C   1 
ATOM   3917 O O   . MET B 1 245 ? 42.966  -47.597 23.337  1.00 62.11  ?  239 MET B O   1 
ATOM   3918 C CB  . MET B 1 245 ? 39.997  -47.357 23.859  1.00 64.14  ?  239 MET B CB  1 
ATOM   3919 C CG  . MET B 1 245 ? 39.062  -46.676 22.898  1.00 70.19  ?  239 MET B CG  1 
ATOM   3920 S SD  . MET B 1 245 ? 37.680  -45.850 23.728  1.00 75.53  ?  239 MET B SD  1 
ATOM   3921 C CE  . MET B 1 245 ? 37.349  -46.888 25.177  1.00 64.04  ?  239 MET B CE  1 
ATOM   3922 N N   . GLU B 1 246 ? 42.145  -48.217 21.331  1.00 65.13  ?  240 GLU B N   1 
ATOM   3923 C CA  . GLU B 1 246 ? 43.346  -47.783 20.630  1.00 64.56  ?  240 GLU B CA  1 
ATOM   3924 C C   . GLU B 1 246 ? 42.965  -47.087 19.323  1.00 63.23  ?  240 GLU B C   1 
ATOM   3925 O O   . GLU B 1 246 ? 41.988  -47.462 18.661  1.00 60.99  ?  240 GLU B O   1 
ATOM   3926 C CB  . GLU B 1 246 ? 44.307  -48.983 20.407  1.00 63.78  ?  240 GLU B CB  1 
ATOM   3927 C CG  . GLU B 1 246 ? 43.991  -49.883 19.219  1.00 72.80  ?  240 GLU B CG  1 
ATOM   3928 C CD  . GLU B 1 246 ? 44.900  -51.126 19.148  1.00 88.30  ?  240 GLU B CD  1 
ATOM   3929 O OE1 . GLU B 1 246 ? 45.322  -51.617 20.227  1.00 90.61  ?  240 GLU B OE1 1 
ATOM   3930 O OE2 . GLU B 1 246 ? 45.179  -51.613 18.017  1.00 86.70  ?  240 GLU B OE2 1 
ATOM   3931 N N   . ARG B 1 247 ? 43.726  -46.058 18.959  1.00 55.24  ?  241 ARG B N   1 
ATOM   3932 C CA  . ARG B 1 247 ? 43.455  -45.374 17.704  1.00 58.11  ?  241 ARG B CA  1 
ATOM   3933 C C   . ARG B 1 247 ? 44.761  -44.935 17.075  1.00 56.64  ?  241 ARG B C   1 
ATOM   3934 O O   . ARG B 1 247 ? 45.636  -44.371 17.746  1.00 58.74  ?  241 ARG B O   1 
ATOM   3935 C CB  . ARG B 1 247 ? 42.530  -44.165 17.908  1.00 61.53  ?  241 ARG B CB  1 
ATOM   3936 C CG  . ARG B 1 247 ? 42.348  -43.275 16.689  1.00 57.24  ?  241 ARG B CG  1 
ATOM   3937 C CD  . ARG B 1 247 ? 41.159  -42.320 16.900  1.00 58.21  ?  241 ARG B CD  1 
ATOM   3938 N NE  . ARG B 1 247 ? 40.740  -41.630 15.680  1.00 61.58  ?  241 ARG B NE  1 
ATOM   3939 C CZ  . ARG B 1 247 ? 39.906  -42.132 14.775  1.00 60.80  ?  241 ARG B CZ  1 
ATOM   3940 N NH1 . ARG B 1 247 ? 39.371  -43.331 14.921  1.00 53.45  ?  241 ARG B NH1 1 
ATOM   3941 N NH2 . ARG B 1 247 ? 39.610  -41.414 13.690  1.00 59.69  ?  241 ARG B NH2 1 
ATOM   3942 N N   . LYS B 1 248 ? 44.897  -45.214 15.790  1.00 57.04  ?  242 LYS B N   1 
ATOM   3943 C CA  . LYS B 1 248 ? 45.960  -44.643 14.984  1.00 61.39  ?  242 LYS B CA  1 
ATOM   3944 C C   . LYS B 1 248 ? 45.283  -43.831 13.894  1.00 59.60  ?  242 LYS B C   1 
ATOM   3945 O O   . LYS B 1 248 ? 44.458  -44.364 13.143  1.00 63.00  ?  242 LYS B O   1 
ATOM   3946 C CB  . LYS B 1 248 ? 46.861  -45.731 14.388  1.00 57.99  ?  242 LYS B CB  1 
ATOM   3947 C CG  . LYS B 1 248 ? 47.971  -45.183 13.496  1.00 62.70  ?  242 LYS B CG  1 
ATOM   3948 C CD  . LYS B 1 248 ? 48.839  -46.313 12.902  1.00 63.35  ?  242 LYS B CD  1 
ATOM   3949 C CE  . LYS B 1 248 ? 47.975  -47.307 12.144  1.00 58.63  ?  242 LYS B CE  1 
ATOM   3950 N NZ  . LYS B 1 248 ? 47.556  -46.770 10.824  1.00 57.34  ?  242 LYS B NZ  1 
ATOM   3951 N N   . GLY B 1 249 ? 45.610  -42.560 13.814  1.00 56.22  ?  243 GLY B N   1 
ATOM   3952 C CA  . GLY B 1 249 ? 45.044  -41.743 12.775  1.00 56.44  ?  243 GLY B CA  1 
ATOM   3953 C C   . GLY B 1 249 ? 45.775  -40.446 12.580  1.00 59.32  ?  243 GLY B C   1 
ATOM   3954 O O   . GLY B 1 249 ? 46.904  -40.276 13.047  1.00 58.22  ?  243 GLY B O   1 
ATOM   3955 N N   . VAL B 1 250 ? 45.107  -39.523 11.879  1.00 58.89  ?  244 VAL B N   1 
ATOM   3956 C CA  . VAL B 1 250 ? 45.722  -38.303 11.363  1.00 54.98  ?  244 VAL B CA  1 
ATOM   3957 C C   . VAL B 1 250 ? 45.247  -37.110 12.179  1.00 54.91  ?  244 VAL B C   1 
ATOM   3958 O O   . VAL B 1 250 ? 44.049  -36.964 12.426  1.00 57.43  ?  244 VAL B O   1 
ATOM   3959 C CB  . VAL B 1 250 ? 45.395  -38.086 9.874   1.00 54.04  ?  244 VAL B CB  1 
ATOM   3960 C CG1 . VAL B 1 250 ? 46.193  -36.883 9.333   1.00 55.54  ?  244 VAL B CG1 1 
ATOM   3961 C CG2 . VAL B 1 250 ? 45.660  -39.337 9.059   1.00 51.85  ?  244 VAL B CG2 1 
ATOM   3962 N N   . SER B 1 251 ? 46.187  -36.254 12.575  1.00 54.54  ?  245 SER B N   1 
ATOM   3963 C CA  . SER B 1 251 ? 45.915  -34.924 13.104  1.00 53.71  ?  245 SER B CA  1 
ATOM   3964 C C   . SER B 1 251 ? 46.227  -33.912 12.009  1.00 59.05  ?  245 SER B C   1 
ATOM   3965 O O   . SER B 1 251 ? 47.399  -33.712 11.668  1.00 55.40  ?  245 SER B O   1 
ATOM   3966 C CB  . SER B 1 251 ? 46.774  -34.628 14.332  1.00 48.30  ?  245 SER B CB  1 
ATOM   3967 O OG  . SER B 1 251 ? 46.442  -35.482 15.401  1.00 53.61  ?  245 SER B OG  1 
ATOM   3968 N N   . GLY B 1 252 ? 45.193  -33.231 11.497  1.00 60.54  ?  246 GLY B N   1 
ATOM   3969 C CA  . GLY B 1 252 ? 45.398  -32.306 10.394  1.00 53.61  ?  246 GLY B CA  1 
ATOM   3970 C C   . GLY B 1 252 ? 45.757  -33.092 9.151   1.00 56.35  ?  246 GLY B C   1 
ATOM   3971 O O   . GLY B 1 252 ? 44.908  -33.785 8.589   1.00 54.69  ?  246 GLY B O   1 
ATOM   3972 N N   . GLN B 1 253 ? 47.023  -33.032 8.739   1.00 60.63  ?  247 GLN B N   1 
ATOM   3973 C CA  . GLN B 1 253 ? 47.561  -33.900 7.693   1.00 58.77  ?  247 GLN B CA  1 
ATOM   3974 C C   . GLN B 1 253 ? 48.690  -34.784 8.192   1.00 58.65  ?  247 GLN B C   1 
ATOM   3975 O O   . GLN B 1 253 ? 49.279  -35.521 7.393   1.00 57.82  ?  247 GLN B O   1 
ATOM   3976 C CB  . GLN B 1 253 ? 48.031  -33.047 6.504   1.00 53.56  ?  247 GLN B CB  1 
ATOM   3977 C CG  . GLN B 1 253 ? 46.854  -32.189 6.061   1.00 66.77  ?  247 GLN B CG  1 
ATOM   3978 C CD  . GLN B 1 253 ? 47.111  -31.243 4.912   1.00 64.56  ?  247 GLN B CD  1 
ATOM   3979 O OE1 . GLN B 1 253 ? 48.156  -30.592 4.823   1.00 65.42  ?  247 GLN B OE1 1 
ATOM   3980 N NE2 . GLN B 1 253 ? 46.118  -31.126 4.042   1.00 61.66  ?  247 GLN B NE2 1 
ATOM   3981 N N   . THR B 1 254 ? 49.013  -34.729 9.484   1.00 55.08  ?  248 THR B N   1 
ATOM   3982 C CA  . THR B 1 254 ? 50.134  -35.472 10.040  1.00 54.14  ?  248 THR B CA  1 
ATOM   3983 C C   . THR B 1 254 ? 49.659  -36.859 10.468  1.00 56.68  ?  248 THR B C   1 
ATOM   3984 O O   . THR B 1 254 ? 48.807  -36.981 11.357  1.00 55.28  ?  248 THR B O   1 
ATOM   3985 C CB  . THR B 1 254 ? 50.754  -34.713 11.213  1.00 58.03  ?  248 THR B CB  1 
ATOM   3986 O OG1 . THR B 1 254 ? 51.344  -33.484 10.746  1.00 59.34  ?  248 THR B OG1 1 
ATOM   3987 C CG2 . THR B 1 254 ? 51.839  -35.539 11.868  1.00 53.07  ?  248 THR B CG2 1 
ATOM   3988 N N   . GLN B 1 255 ? 50.215  -37.889 9.822   1.00 53.33  ?  249 GLN B N   1 
ATOM   3989 C CA  . GLN B 1 255 ? 49.908  -39.302 10.009  1.00 55.48  ?  249 GLN B CA  1 
ATOM   3990 C C   . GLN B 1 255 ? 50.528  -39.872 11.283  1.00 55.28  ?  249 GLN B C   1 
ATOM   3991 O O   . GLN B 1 255 ? 51.430  -39.289 11.900  1.00 55.49  ?  249 GLN B O   1 
ATOM   3992 C CB  . GLN B 1 255 ? 50.440  -40.132 8.841   1.00 57.16  ?  249 GLN B CB  1 
ATOM   3993 C CG  . GLN B 1 255 ? 50.367  -39.452 7.503   1.00 58.26  ?  249 GLN B CG  1 
ATOM   3994 C CD  . GLN B 1 255 ? 48.946  -39.355 7.052   1.00 60.53  ?  249 GLN B CD  1 
ATOM   3995 O OE1 . GLN B 1 255 ? 48.303  -40.370 6.781   1.00 60.79  ?  249 GLN B OE1 1 
ATOM   3996 N NE2 . GLN B 1 255 ? 48.422  -38.140 7.007   1.00 54.88  ?  249 GLN B NE2 1 
ATOM   3997 N N   . ASN B 1 256 ? 50.034  -41.069 11.645  1.00 56.98  ?  250 ASN B N   1 
ATOM   3998 C CA  . ASN B 1 256 ? 50.694  -41.970 12.599  1.00 57.85  ?  250 ASN B CA  1 
ATOM   3999 C C   . ASN B 1 256 ? 50.673  -41.397 14.012  1.00 58.50  ?  250 ASN B C   1 
ATOM   4000 O O   . ASN B 1 256 ? 51.663  -41.463 14.737  1.00 57.23  ?  250 ASN B O   1 
ATOM   4001 C CB  . ASN B 1 256 ? 52.128  -42.296 12.164  1.00 57.24  ?  250 ASN B CB  1 
ATOM   4002 C CG  . ASN B 1 256 ? 52.731  -43.479 12.938  1.00 60.42  ?  250 ASN B CG  1 
ATOM   4003 O OD1 . ASN B 1 256 ? 52.074  -44.506 13.118  1.00 62.31  ?  250 ASN B OD1 1 
ATOM   4004 N ND2 . ASN B 1 256 ? 53.989  -43.334 13.390  1.00 50.88  ?  250 ASN B ND2 1 
ATOM   4005 N N   . GLN B 1 257 ? 49.542  -40.800 14.388  1.00 60.82  ?  251 GLN B N   1 
ATOM   4006 C CA  . GLN B 1 257 ? 49.292  -40.386 15.763  1.00 60.49  ?  251 GLN B CA  1 
ATOM   4007 C C   . GLN B 1 257 ? 48.663  -41.556 16.519  1.00 60.49  ?  251 GLN B C   1 
ATOM   4008 O O   . GLN B 1 257 ? 47.701  -42.171 16.036  1.00 59.15  ?  251 GLN B O   1 
ATOM   4009 C CB  . GLN B 1 257 ? 48.386  -39.157 15.780  1.00 57.40  ?  251 GLN B CB  1 
ATOM   4010 C CG  . GLN B 1 257 ? 48.909  -38.045 14.888  1.00 53.65  ?  251 GLN B CG  1 
ATOM   4011 C CD  . GLN B 1 257 ? 49.910  -37.158 15.600  1.00 59.01  ?  251 GLN B CD  1 
ATOM   4012 O OE1 . GLN B 1 257 ? 51.111  -37.446 15.627  1.00 63.40  ?  251 GLN B OE1 1 
ATOM   4013 N NE2 . GLN B 1 257 ? 49.416  -36.077 16.209  1.00 54.15  ?  251 GLN B NE2 1 
ATOM   4014 N N   . LEU B 1 258 ? 49.231  -41.888 17.682  1.00 57.26  ?  252 LEU B N   1 
ATOM   4015 C CA  . LEU B 1 258 ? 48.902  -43.121 18.382  1.00 57.44  ?  252 LEU B CA  1 
ATOM   4016 C C   . LEU B 1 258 ? 48.292  -42.809 19.738  1.00 57.69  ?  252 LEU B C   1 
ATOM   4017 O O   . LEU B 1 258 ? 48.851  -42.017 20.501  1.00 60.15  ?  252 LEU B O   1 
ATOM   4018 C CB  . LEU B 1 258 ? 50.145  -44.003 18.544  1.00 57.79  ?  252 LEU B CB  1 
ATOM   4019 C CG  . LEU B 1 258 ? 50.979  -44.101 17.260  1.00 59.97  ?  252 LEU B CG  1 
ATOM   4020 C CD1 . LEU B 1 258 ? 52.309  -44.801 17.497  1.00 62.46  ?  252 LEU B CD1 1 
ATOM   4021 C CD2 . LEU B 1 258 ? 50.201  -44.798 16.178  1.00 56.85  ?  252 LEU B CD2 1 
ATOM   4022 N N   . PHE B 1 259 ? 47.162  -43.459 20.041  1.00 54.93  ?  253 PHE B N   1 
ATOM   4023 C CA  . PHE B 1 259 ? 46.411  -43.235 21.273  1.00 57.53  ?  253 PHE B CA  1 
ATOM   4024 C C   . PHE B 1 259 ? 45.956  -44.565 21.861  1.00 56.61  ?  253 PHE B C   1 
ATOM   4025 O O   . PHE B 1 259 ? 45.274  -45.351 21.188  1.00 57.83  ?  253 PHE B O   1 
ATOM   4026 C CB  . PHE B 1 259 ? 45.172  -42.336 21.036  1.00 58.07  ?  253 PHE B CB  1 
ATOM   4027 C CG  . PHE B 1 259 ? 45.473  -41.034 20.316  1.00 58.48  ?  253 PHE B CG  1 
ATOM   4028 C CD1 . PHE B 1 259 ? 45.492  -40.976 18.924  1.00 52.22  ?  253 PHE B CD1 1 
ATOM   4029 C CD2 . PHE B 1 259 ? 45.716  -39.874 21.032  1.00 54.78  ?  253 PHE B CD2 1 
ATOM   4030 C CE1 . PHE B 1 259 ? 45.747  -39.809 18.279  1.00 52.38  ?  253 PHE B CE1 1 
ATOM   4031 C CE2 . PHE B 1 259 ? 45.982  -38.697 20.387  1.00 51.10  ?  253 PHE B CE2 1 
ATOM   4032 C CZ  . PHE B 1 259 ? 46.007  -38.657 19.013  1.00 55.97  ?  253 PHE B CZ  1 
ATOM   4033 N N   . THR B 1 260 ? 46.290  -44.790 23.134  1.00 53.07  ?  254 THR B N   1 
ATOM   4034 C CA  . THR B 1 260 ? 45.829  -45.960 23.861  1.00 57.84  ?  254 THR B CA  1 
ATOM   4035 C C   . THR B 1 260 ? 45.138  -45.544 25.147  1.00 55.40  ?  254 THR B C   1 
ATOM   4036 O O   . THR B 1 260 ? 45.649  -44.697 25.890  1.00 56.37  ?  254 THR B O   1 
ATOM   4037 C CB  . THR B 1 260 ? 46.978  -46.897 24.237  1.00 58.71  ?  254 THR B CB  1 
ATOM   4038 O OG1 . THR B 1 260 ? 47.831  -47.067 23.113  1.00 60.99  ?  254 THR B OG1 1 
ATOM   4039 C CG2 . THR B 1 260 ? 46.415  -48.243 24.595  1.00 61.57  ?  254 THR B CG2 1 
ATOM   4040 N N   . TYR B 1 261 ? 44.010  -46.195 25.424  1.00 53.00  ?  255 TYR B N   1 
ATOM   4041 C CA  . TYR B 1 261 ? 43.227  -46.002 26.632  1.00 52.92  ?  255 TYR B CA  1 
ATOM   4042 C C   . TYR B 1 261 ? 42.891  -47.361 27.219  1.00 55.44  ?  255 TYR B C   1 
ATOM   4043 O O   . TYR B 1 261 ? 42.287  -48.193 26.533  1.00 53.91  ?  255 TYR B O   1 
ATOM   4044 C CB  . TYR B 1 261 ? 41.904  -45.264 26.379  1.00 58.16  ?  255 TYR B CB  1 
ATOM   4045 C CG  . TYR B 1 261 ? 41.148  -45.121 27.697  1.00 55.25  ?  255 TYR B CG  1 
ATOM   4046 C CD1 . TYR B 1 261 ? 41.586  -44.207 28.663  1.00 54.40  ?  255 TYR B CD1 1 
ATOM   4047 C CD2 . TYR B 1 261 ? 40.056  -45.934 28.011  1.00 52.50  ?  255 TYR B CD2 1 
ATOM   4048 C CE1 . TYR B 1 261 ? 40.935  -44.072 29.896  1.00 54.24  ?  255 TYR B CE1 1 
ATOM   4049 C CE2 . TYR B 1 261 ? 39.408  -45.821 29.233  1.00 50.94  ?  255 TYR B CE2 1 
ATOM   4050 C CZ  . TYR B 1 261 ? 39.850  -44.876 30.160  1.00 57.99  ?  255 TYR B CZ  1 
ATOM   4051 O OH  . TYR B 1 261 ? 39.200  -44.734 31.351  1.00 56.05  ?  255 TYR B OH  1 
ATOM   4052 N N   . GLU B 1 262 ? 43.199  -47.558 28.504  1.00 57.79  ?  256 GLU B N   1 
ATOM   4053 C CA  . GLU B 1 262 ? 43.024  -48.867 29.132  1.00 62.15  ?  256 GLU B CA  1 
ATOM   4054 C C   . GLU B 1 262 ? 42.412  -48.741 30.520  1.00 55.22  ?  256 GLU B C   1 
ATOM   4055 O O   . GLU B 1 262 ? 42.778  -47.843 31.283  1.00 54.64  ?  256 GLU B O   1 
ATOM   4056 C CB  . GLU B 1 262 ? 44.371  -49.585 29.247  1.00 56.75  ?  256 GLU B CB  1 
ATOM   4057 C CG  . GLU B 1 262 ? 44.685  -50.510 28.098  1.00 71.57  ?  256 GLU B CG  1 
ATOM   4058 C CD  . GLU B 1 262 ? 45.550  -51.698 28.526  1.00 80.01  ?  256 GLU B CD  1 
ATOM   4059 O OE1 . GLU B 1 262 ? 44.996  -52.734 28.978  1.00 77.07  ?  256 GLU B OE1 1 
ATOM   4060 O OE2 . GLU B 1 262 ? 46.788  -51.568 28.428  1.00 78.25  -1 256 GLU B OE2 1 
ATOM   4061 N N   . MET B 1 263 ? 41.501  -49.651 30.864  1.00 54.06  ?  257 MET B N   1 
ATOM   4062 C CA  . MET B 1 263 ? 41.057  -49.737 32.247  1.00 52.66  ?  257 MET B CA  1 
ATOM   4063 C C   . MET B 1 263 ? 40.857  -51.186 32.659  1.00 56.20  ?  257 MET B C   1 
ATOM   4064 O O   . MET B 1 263 ? 40.397  -52.030 31.879  1.00 61.17  ?  257 MET B O   1 
ATOM   4065 C CB  . MET B 1 263 ? 39.750  -48.987 32.536  1.00 58.05  ?  257 MET B CB  1 
ATOM   4066 C CG  . MET B 1 263 ? 38.690  -49.083 31.481  1.00 61.73  ?  257 MET B CG  1 
ATOM   4067 S SD  . MET B 1 263 ? 37.110  -48.345 32.031  1.00 70.28  ?  257 MET B SD  1 
ATOM   4068 C CE  . MET B 1 263 ? 37.570  -46.690 32.375  1.00 59.92  ?  257 MET B CE  1 
ATOM   4069 N N   . ARG B 1 264 ? 41.163  -51.446 33.920  1.00 54.51  ?  258 ARG B N   1 
ATOM   4070 C CA  . ARG B 1 264 ? 41.002  -52.757 34.547  1.00 59.99  ?  258 ARG B CA  1 
ATOM   4071 C C   . ARG B 1 264 ? 40.213  -52.486 35.827  1.00 59.58  ?  258 ARG B C   1 
ATOM   4072 O O   . ARG B 1 264 ? 40.775  -51.989 36.808  1.00 63.75  ?  258 ARG B O   1 
ATOM   4073 C CB  . ARG B 1 264 ? 42.364  -53.408 34.839  1.00 56.29  ?  258 ARG B CB  1 
ATOM   4074 C CG  . ARG B 1 264 ? 43.194  -53.862 33.607  1.00 61.01  ?  258 ARG B CG  1 
ATOM   4075 C CD  . ARG B 1 264 ? 44.645  -53.324 33.655  1.00 71.96  ?  258 ARG B CD  1 
ATOM   4076 N NE  . ARG B 1 264 ? 44.636  -51.867 33.859  1.00 77.98  ?  258 ARG B NE  1 
ATOM   4077 C CZ  . ARG B 1 264 ? 45.545  -51.004 33.411  1.00 63.38  ?  258 ARG B CZ  1 
ATOM   4078 N NH1 . ARG B 1 264 ? 46.554  -51.384 32.645  1.00 73.95  ?  258 ARG B NH1 1 
ATOM   4079 N NH2 . ARG B 1 264 ? 45.437  -49.732 33.744  1.00 49.01  ?  258 ARG B NH2 1 
ATOM   4080 N N   . ILE B 1 265 ? 38.912  -52.775 35.834  1.00 54.40  ?  259 ILE B N   1 
ATOM   4081 C CA  . ILE B 1 265 ? 38.038  -52.216 36.857  1.00 55.07  ?  259 ILE B CA  1 
ATOM   4082 C C   . ILE B 1 265 ? 36.962  -53.210 37.240  1.00 57.07  ?  259 ILE B C   1 
ATOM   4083 O O   . ILE B 1 265 ? 36.669  -54.162 36.513  1.00 56.01  ?  259 ILE B O   1 
ATOM   4084 C CB  . ILE B 1 265 ? 37.380  -50.884 36.407  1.00 58.61  ?  259 ILE B CB  1 
ATOM   4085 C CG1 . ILE B 1 265 ? 36.824  -51.003 34.988  1.00 54.90  ?  259 ILE B CG1 1 
ATOM   4086 C CG2 . ILE B 1 265 ? 38.411  -49.724 36.445  1.00 54.82  ?  259 ILE B CG2 1 
ATOM   4087 C CD1 . ILE B 1 265 ? 35.465  -51.546 34.925  1.00 57.37  ?  259 ILE B CD1 1 
ATOM   4088 N N   . ASN B 1 266 ? 36.391  -52.968 38.421  1.00 56.76  ?  260 ASN B N   1 
ATOM   4089 C CA  . ASN B 1 266 ? 35.114  -53.548 38.826  1.00 59.04  ?  260 ASN B CA  1 
ATOM   4090 C C   . ASN B 1 266 ? 33.987  -52.866 38.047  1.00 56.88  ?  260 ASN B C   1 
ATOM   4091 O O   . ASN B 1 266 ? 33.669  -51.702 38.295  1.00 56.07  ?  260 ASN B O   1 
ATOM   4092 C CB  . ASN B 1 266 ? 34.939  -53.355 40.331  1.00 56.38  ?  260 ASN B CB  1 
ATOM   4093 C CG  . ASN B 1 266 ? 33.703  -54.025 40.859  1.00 57.16  ?  260 ASN B CG  1 
ATOM   4094 O OD1 . ASN B 1 266 ? 32.651  -54.022 40.214  1.00 57.64  ?  260 ASN B OD1 1 
ATOM   4095 N ND2 . ASN B 1 266 ? 33.821  -54.629 42.037  1.00 57.31  ?  260 ASN B ND2 1 
ATOM   4096 N N   . ASN B 1 267 ? 33.363  -53.582 37.128  1.00 59.03  ?  261 ASN B N   1 
ATOM   4097 C CA  . ASN B 1 267 ? 32.406  -52.945 36.226  1.00 57.88  ?  261 ASN B CA  1 
ATOM   4098 C C   . ASN B 1 267 ? 31.215  -52.293 36.936  1.00 62.07  ?  261 ASN B C   1 
ATOM   4099 O O   . ASN B 1 267 ? 30.928  -51.114 36.650  1.00 60.67  ?  261 ASN B O   1 
ATOM   4100 C CB  . ASN B 1 267 ? 31.938  -53.961 35.179  1.00 56.50  ?  261 ASN B CB  1 
ATOM   4101 C CG  . ASN B 1 267 ? 31.367  -53.300 33.952  1.00 64.24  ?  261 ASN B CG  1 
ATOM   4102 O OD1 . ASN B 1 267 ? 31.597  -52.118 33.706  1.00 69.11  ?  261 ASN B OD1 1 
ATOM   4103 N ND2 . ASN B 1 267 ? 30.625  -54.056 33.171  1.00 67.13  ?  261 ASN B ND2 1 
ATOM   4104 N N   . PRO B 1 268 ? 30.469  -52.965 37.823  1.00 61.25  ?  262 PRO B N   1 
ATOM   4105 C CA  . PRO B 1 268 ? 29.330  -52.261 38.456  1.00 58.70  ?  262 PRO B CA  1 
ATOM   4106 C C   . PRO B 1 268 ? 29.767  -51.153 39.388  1.00 56.52  ?  262 PRO B C   1 
ATOM   4107 O O   . PRO B 1 268 ? 29.068  -50.141 39.511  1.00 60.19  ?  262 PRO B O   1 
ATOM   4108 C CB  . PRO B 1 268 ? 28.571  -53.369 39.209  1.00 58.56  ?  262 PRO B CB  1 
ATOM   4109 C CG  . PRO B 1 268 ? 29.505  -54.537 39.276  1.00 60.90  ?  262 PRO B CG  1 
ATOM   4110 C CD  . PRO B 1 268 ? 30.469  -54.409 38.122  1.00 59.60  ?  262 PRO B CD  1 
ATOM   4111 N N   . ALA B 1 269 ? 30.905  -51.311 40.052  1.00 58.78  ?  263 ALA B N   1 
ATOM   4112 C CA  . ALA B 1 269 ? 31.433  -50.232 40.873  1.00 58.00  ?  263 ALA B CA  1 
ATOM   4113 C C   . ALA B 1 269 ? 31.709  -48.990 40.035  1.00 58.49  ?  263 ALA B C   1 
ATOM   4114 O O   . ALA B 1 269 ? 31.393  -47.872 40.454  1.00 59.35  ?  263 ALA B O   1 
ATOM   4115 C CB  . ALA B 1 269 ? 32.700  -50.697 41.576  1.00 57.95  ?  263 ALA B CB  1 
ATOM   4116 N N   . LEU B 1 270 ? 32.292  -49.163 38.844  1.00 55.50  ?  264 LEU B N   1 
ATOM   4117 C CA  . LEU B 1 270 ? 32.553  -48.008 37.996  1.00 55.78  ?  264 LEU B CA  1 
ATOM   4118 C C   . LEU B 1 270 ? 31.255  -47.450 37.425  1.00 58.83  ?  264 LEU B C   1 
ATOM   4119 O O   . LEU B 1 270 ? 31.078  -46.228 37.349  1.00 55.27  ?  264 LEU B O   1 
ATOM   4120 C CB  . LEU B 1 270 ? 33.518  -48.373 36.868  1.00 54.94  ?  264 LEU B CB  1 
ATOM   4121 C CG  . LEU B 1 270 ? 33.851  -47.189 35.945  1.00 53.55  ?  264 LEU B CG  1 
ATOM   4122 C CD1 . LEU B 1 270 ? 34.356  -45.982 36.763  1.00 50.59  ?  264 LEU B CD1 1 
ATOM   4123 C CD2 . LEU B 1 270 ? 34.850  -47.576 34.861  1.00 52.41  ?  264 LEU B CD2 1 
ATOM   4124 N N   . THR B 1 271 ? 30.336  -48.331 37.025  1.00 56.81  ?  265 THR B N   1 
ATOM   4125 C CA  . THR B 1 271 ? 29.096  -47.877 36.408  1.00 56.09  ?  265 THR B CA  1 
ATOM   4126 C C   . THR B 1 271 ? 28.257  -47.087 37.401  1.00 57.45  ?  265 THR B C   1 
ATOM   4127 O O   . THR B 1 271 ? 27.716  -46.027 37.070  1.00 59.53  ?  265 THR B O   1 
ATOM   4128 C CB  . THR B 1 271 ? 28.302  -49.072 35.858  1.00 56.90  ?  265 THR B CB  1 
ATOM   4129 O OG1 . THR B 1 271 ? 28.862  -49.504 34.607  1.00 58.80  ?  265 THR B OG1 1 
ATOM   4130 C CG2 . THR B 1 271 ? 26.853  -48.689 35.627  1.00 56.65  ?  265 THR B CG2 1 
ATOM   4131 N N   . SER B 1 272 ? 28.134  -47.584 38.629  1.00 58.07  ?  266 SER B N   1 
ATOM   4132 C CA  . SER B 1 272 ? 27.353  -46.851 39.617  1.00 59.56  ?  266 SER B CA  1 
ATOM   4133 C C   . SER B 1 272 ? 28.059  -45.562 40.032  1.00 59.22  ?  266 SER B C   1 
ATOM   4134 O O   . SER B 1 272 ? 27.395  -44.570 40.374  1.00 54.72  ?  266 SER B O   1 
ATOM   4135 C CB  . SER B 1 272 ? 27.083  -47.732 40.835  1.00 57.31  ?  266 SER B CB  1 
ATOM   4136 O OG  . SER B 1 272 ? 28.314  -48.181 41.381  1.00 57.78  ?  266 SER B OG  1 
ATOM   4137 N N   . GLN B 1 273 ? 29.396  -45.547 40.004  1.00 52.84  ?  267 GLN B N   1 
ATOM   4138 C CA  . GLN B 1 273 ? 30.087  -44.299 40.300  1.00 53.92  ?  267 GLN B CA  1 
ATOM   4139 C C   . GLN B 1 273 ? 29.810  -43.254 39.228  1.00 55.02  ?  267 GLN B C   1 
ATOM   4140 O O   . GLN B 1 273 ? 29.660  -42.060 39.525  1.00 51.29  ?  267 GLN B O   1 
ATOM   4141 C CB  . GLN B 1 273 ? 31.583  -44.533 40.418  1.00 51.46  ?  267 GLN B CB  1 
ATOM   4142 C CG  . GLN B 1 273 ? 32.385  -43.238 40.550  1.00 50.85  ?  267 GLN B CG  1 
ATOM   4143 C CD  . GLN B 1 273 ? 32.009  -42.468 41.794  1.00 54.02  ?  267 GLN B CD  1 
ATOM   4144 O OE1 . GLN B 1 273 ? 32.554  -42.702 42.876  1.00 58.60  ?  267 GLN B OE1 1 
ATOM   4145 N NE2 . GLN B 1 273 ? 31.056  -41.558 41.657  1.00 56.28  ?  267 GLN B NE2 1 
ATOM   4146 N N   . VAL B 1 274 ? 29.767  -43.684 37.971  1.00 50.85  ?  268 VAL B N   1 
ATOM   4147 C CA  . VAL B 1 274 ? 29.560  -42.746 36.888  1.00 50.62  ?  268 VAL B CA  1 
ATOM   4148 C C   . VAL B 1 274 ? 28.137  -42.217 36.934  1.00 54.63  ?  268 VAL B C   1 
ATOM   4149 O O   . VAL B 1 274 ? 27.896  -41.020 36.735  1.00 57.57  ?  268 VAL B O   1 
ATOM   4150 C CB  . VAL B 1 274 ? 29.918  -43.425 35.555  1.00 51.82  ?  268 VAL B CB  1 
ATOM   4151 C CG1 . VAL B 1 274 ? 29.325  -42.706 34.388  1.00 47.97  ?  268 VAL B CG1 1 
ATOM   4152 C CG2 . VAL B 1 274 ? 31.451  -43.529 35.427  1.00 50.13  ?  268 VAL B CG2 1 
ATOM   4153 N N   . MET B 1 275 ? 27.178  -43.065 37.290  1.00 53.72  ?  269 MET B N   1 
ATOM   4154 C CA  . MET B 1 275 ? 25.825  -42.547 37.447  1.00 53.37  ?  269 MET B CA  1 
ATOM   4155 C C   . MET B 1 275 ? 25.740  -41.530 38.582  1.00 49.10  ?  269 MET B C   1 
ATOM   4156 O O   . MET B 1 275 ? 25.114  -40.482 38.422  1.00 55.15  ?  269 MET B O   1 
ATOM   4157 C CB  . MET B 1 275 ? 24.826  -43.688 37.636  1.00 51.80  ?  269 MET B CB  1 
ATOM   4158 C CG  . MET B 1 275 ? 24.968  -44.796 36.614  1.00 57.52  ?  269 MET B CG  1 
ATOM   4159 S SD  . MET B 1 275 ? 23.878  -46.219 36.916  1.00 65.43  ?  269 MET B SD  1 
ATOM   4160 C CE  . MET B 1 275 ? 22.325  -45.415 36.534  1.00 60.86  ?  269 MET B CE  1 
ATOM   4161 N N   . ILE B 1 276 ? 26.378  -41.803 39.721  1.00 51.69  ?  270 ILE B N   1 
ATOM   4162 C CA  . ILE B 1 276 ? 26.354  -40.842 40.824  1.00 50.46  ?  270 ILE B CA  1 
ATOM   4163 C C   . ILE B 1 276 ? 26.991  -39.529 40.384  1.00 51.52  ?  270 ILE B C   1 
ATOM   4164 O O   . ILE B 1 276 ? 26.503  -38.447 40.720  1.00 52.79  ?  270 ILE B O   1 
ATOM   4165 C CB  . ILE B 1 276 ? 27.039  -41.414 42.089  1.00 50.72  ?  270 ILE B CB  1 
ATOM   4166 C CG1 . ILE B 1 276 ? 26.025  -42.081 43.038  1.00 53.32  ?  270 ILE B CG1 1 
ATOM   4167 C CG2 . ILE B 1 276 ? 27.780  -40.327 42.869  1.00 43.79  ?  270 ILE B CG2 1 
ATOM   4168 C CD1 . ILE B 1 276 ? 25.245  -43.243 42.446  1.00 47.38  ?  270 ILE B CD1 1 
ATOM   4169 N N   . ALA B 1 277 ? 28.060  -39.598 39.590  1.00 50.66  ?  271 ALA B N   1 
ATOM   4170 C CA  . ALA B 1 277 ? 28.656  -38.370 39.077  1.00 52.23  ?  271 ALA B CA  1 
ATOM   4171 C C   . ALA B 1 277 ? 27.694  -37.648 38.148  1.00 53.28  ?  271 ALA B C   1 
ATOM   4172 O O   . ALA B 1 277 ? 27.660  -36.414 38.113  1.00 52.66  ?  271 ALA B O   1 
ATOM   4173 C CB  . ALA B 1 277 ? 29.965  -38.667 38.348  1.00 47.71  ?  271 ALA B CB  1 
ATOM   4174 N N   . SER B 1 278 ? 26.924  -38.400 37.370  1.00 50.47  ?  272 SER B N   1 
ATOM   4175 C CA  . SER B 1 278 ? 25.934  -37.777 36.505  1.00 53.13  ?  272 SER B CA  1 
ATOM   4176 C C   . SER B 1 278 ? 24.783  -37.167 37.301  1.00 54.04  ?  272 SER B C   1 
ATOM   4177 O O   . SER B 1 278 ? 24.244  -36.130 36.900  1.00 51.34  ?  272 SER B O   1 
ATOM   4178 C CB  . SER B 1 278 ? 25.426  -38.801 35.505  1.00 52.99  ?  272 SER B CB  1 
ATOM   4179 O OG  . SER B 1 278 ? 26.516  -39.240 34.718  1.00 52.55  ?  272 SER B OG  1 
ATOM   4180 N N   . ALA B 1 279 ? 24.394  -37.780 38.426  1.00 53.47  ?  273 ALA B N   1 
ATOM   4181 C CA  . ALA B 1 279 ? 23.426  -37.133 39.313  1.00 54.97  ?  273 ALA B CA  1 
ATOM   4182 C C   . ALA B 1 279 ? 23.886  -35.735 39.680  1.00 55.62  ?  273 ALA B C   1 
ATOM   4183 O O   . ALA B 1 279 ? 23.082  -34.799 39.743  1.00 60.96  ?  273 ALA B O   1 
ATOM   4184 C CB  . ALA B 1 279 ? 23.226  -37.950 40.586  1.00 51.98  ?  273 ALA B CB  1 
ATOM   4185 N N   . ARG B 1 280 ? 25.184  -35.580 39.931  1.00 50.50  ?  274 ARG B N   1 
ATOM   4186 C CA  . ARG B 1 280 ? 25.732  -34.266 40.203  1.00 52.66  ?  274 ARG B CA  1 
ATOM   4187 C C   . ARG B 1 280 ? 25.641  -33.373 38.974  1.00 52.46  ?  274 ARG B C   1 
ATOM   4188 O O   . ARG B 1 280 ? 25.299  -32.194 39.094  1.00 55.66  ?  274 ARG B O   1 
ATOM   4189 C CB  . ARG B 1 280 ? 27.170  -34.413 40.690  1.00 55.49  ?  274 ARG B CB  1 
ATOM   4190 C CG  . ARG B 1 280 ? 28.033  -33.212 40.501  1.00 52.86  ?  274 ARG B CG  1 
ATOM   4191 C CD  . ARG B 1 280 ? 29.440  -33.486 41.042  1.00 56.96  ?  274 ARG B CD  1 
ATOM   4192 N NE  . ARG B 1 280 ? 29.443  -34.275 42.272  1.00 59.73  ?  274 ARG B NE  1 
ATOM   4193 C CZ  . ARG B 1 280 ? 30.025  -35.463 42.409  1.00 58.20  ?  274 ARG B CZ  1 
ATOM   4194 N NH1 . ARG B 1 280 ? 30.635  -36.052 41.397  1.00 52.35  ?  274 ARG B NH1 1 
ATOM   4195 N NH2 . ARG B 1 280 ? 29.974  -36.082 43.587  1.00 52.78  ?  274 ARG B NH2 1 
ATOM   4196 N N   . ALA B 1 281 ? 25.886  -33.920 37.774  1.00 51.56  ?  275 ALA B N   1 
ATOM   4197 C CA  . ALA B 1 281 ? 25.862  -33.068 36.585  1.00 53.13  ?  275 ALA B CA  1 
ATOM   4198 C C   . ALA B 1 281 ? 24.444  -32.670 36.196  1.00 54.87  ?  275 ALA B C   1 
ATOM   4199 O O   . ALA B 1 281 ? 24.242  -31.586 35.626  1.00 50.02  ?  275 ALA B O   1 
ATOM   4200 C CB  . ALA B 1 281 ? 26.533  -33.752 35.405  1.00 46.34  ?  275 ALA B CB  1 
ATOM   4201 N N   . ALA B 1 282 ? 23.470  -33.544 36.481  1.00 56.31  ?  276 ALA B N   1 
ATOM   4202 C CA  . ALA B 1 282 ? 22.072  -33.285 36.147  1.00 52.97  ?  276 ALA B CA  1 
ATOM   4203 C C   . ALA B 1 282 ? 21.563  -32.012 36.817  1.00 52.64  ?  276 ALA B C   1 
ATOM   4204 O O   . ALA B 1 282 ? 20.797  -31.256 36.215  1.00 58.83  ?  276 ALA B O   1 
ATOM   4205 C CB  . ALA B 1 282 ? 21.218  -34.485 36.550  1.00 50.08  ?  276 ALA B CB  1 
ATOM   4206 N N   . MET B 1 283 ? 21.996  -31.749 38.052  1.00 52.16  ?  277 MET B N   1 
ATOM   4207 C CA  . MET B 1 283 ? 21.623  -30.544 38.784  1.00 55.34  ?  277 MET B CA  1 
ATOM   4208 C C   . MET B 1 283 ? 22.182  -29.255 38.179  1.00 58.71  ?  277 MET B C   1 
ATOM   4209 O O   . MET B 1 283 ? 21.820  -28.169 38.645  1.00 60.67  ?  277 MET B O   1 
ATOM   4210 C CB  . MET B 1 283 ? 22.078  -30.646 40.245  1.00 53.73  ?  277 MET B CB  1 
ATOM   4211 C CG  . MET B 1 283 ? 21.554  -31.854 41.029  1.00 54.98  ?  277 MET B CG  1 
ATOM   4212 S SD  . MET B 1 283 ? 19.760  -31.790 41.265  1.00 62.26  ?  277 MET B SD  1 
ATOM   4213 C CE  . MET B 1 283 ? 19.650  -30.555 42.551  1.00 53.82  ?  277 MET B CE  1 
ATOM   4214 N N   . ARG B 1 284 ? 23.047  -29.335 37.170  1.00 56.20  ?  278 ARG B N   1 
ATOM   4215 C CA  . ARG B 1 284 ? 23.593  -28.147 36.523  1.00 55.92  ?  278 ARG B CA  1 
ATOM   4216 C C   . ARG B 1 284 ? 23.164  -28.001 35.071  1.00 50.53  ?  278 ARG B C   1 
ATOM   4217 O O   . ARG B 1 284 ? 23.744  -27.187 34.348  1.00 55.22  ?  278 ARG B O   1 
ATOM   4218 C CB  . ARG B 1 284 ? 25.122  -28.149 36.612  1.00 48.49  ?  278 ARG B CB  1 
ATOM   4219 C CG  . ARG B 1 284 ? 25.600  -28.450 38.000  1.00 50.61  ?  278 ARG B CG  1 
ATOM   4220 C CD  . ARG B 1 284 ? 27.048  -28.883 38.009  1.00 51.63  ?  278 ARG B CD  1 
ATOM   4221 N NE  . ARG B 1 284 ? 27.719  -28.467 39.230  1.00 46.71  ?  278 ARG B NE  1 
ATOM   4222 C CZ  . ARG B 1 284 ? 28.701  -29.148 39.802  1.00 54.85  ?  278 ARG B CZ  1 
ATOM   4223 N NH1 . ARG B 1 284 ? 29.154  -30.282 39.280  1.00 51.84  ?  278 ARG B NH1 1 
ATOM   4224 N NH2 . ARG B 1 284 ? 29.247  -28.678 40.926  1.00 55.56  ?  278 ARG B NH2 1 
ATOM   4225 N N   . GLN B 1 285 ? 22.185  -28.759 34.615  1.00 50.60  ?  279 GLN B N   1 
ATOM   4226 C CA  . GLN B 1 285 ? 21.752  -28.633 33.235  1.00 55.14  ?  279 GLN B CA  1 
ATOM   4227 C C   . GLN B 1 285 ? 20.412  -27.903 33.153  1.00 60.05  ?  279 GLN B C   1 
ATOM   4228 O O   . GLN B 1 285 ? 19.683  -27.733 34.136  1.00 57.27  ?  279 GLN B O   1 
ATOM   4229 C CB  . GLN B 1 285 ? 21.634  -30.008 32.562  1.00 55.85  ?  279 GLN B CB  1 
ATOM   4230 C CG  . GLN B 1 285 ? 22.878  -30.886 32.615  1.00 55.81  ?  279 GLN B CG  1 
ATOM   4231 C CD  . GLN B 1 285 ? 24.157  -30.121 32.408  1.00 55.59  ?  279 GLN B CD  1 
ATOM   4232 O OE1 . GLN B 1 285 ? 24.357  -29.478 31.371  1.00 50.69  ?  279 GLN B OE1 1 
ATOM   4233 N NE2 . GLN B 1 285 ? 25.043  -30.185 33.402  1.00 53.54  ?  279 GLN B NE2 1 
ATOM   4234 N N   . LYS B 1 286 ? 20.096  -27.479 31.952  1.00 58.38  ?  280 LYS B N   1 
ATOM   4235 C CA  . LYS B 1 286 ? 18.746  -27.061 31.645  1.00 61.81  ?  280 LYS B CA  1 
ATOM   4236 C C   . LYS B 1 286 ? 17.915  -28.292 31.293  1.00 64.92  ?  280 LYS B C   1 
ATOM   4237 O O   . LYS B 1 286 ? 18.476  -29.332 30.924  1.00 62.81  ?  280 LYS B O   1 
ATOM   4238 C CB  . LYS B 1 286 ? 18.802  -26.071 30.496  1.00 64.22  ?  280 LYS B CB  1 
ATOM   4239 C CG  . LYS B 1 286 ? 19.755  -24.924 30.861  1.00 65.43  ?  280 LYS B CG  1 
ATOM   4240 C CD  . LYS B 1 286 ? 19.291  -23.577 30.384  1.00 72.90  ?  280 LYS B CD  1 
ATOM   4241 C CE  . LYS B 1 286 ? 20.392  -22.937 29.541  1.00 80.26  ?  280 LYS B CE  1 
ATOM   4242 N NZ  . LYS B 1 286 ? 20.146  -21.520 29.252  1.00 76.60  ?  280 LYS B NZ  1 
ATOM   4243 N N   . PRO B 1 287 ? 16.584  -28.222 31.448  1.00 61.08  ?  281 PRO B N   1 
ATOM   4244 C CA  . PRO B 1 287 ? 15.738  -29.387 31.165  1.00 57.95  ?  281 PRO B CA  1 
ATOM   4245 C C   . PRO B 1 287 ? 16.014  -29.996 29.796  1.00 60.00  ?  281 PRO B C   1 
ATOM   4246 O O   . PRO B 1 287 ? 16.380  -29.298 28.848  1.00 63.39  ?  281 PRO B O   1 
ATOM   4247 C CB  . PRO B 1 287 ? 14.318  -28.816 31.254  1.00 60.19  ?  281 PRO B CB  1 
ATOM   4248 C CG  . PRO B 1 287 ? 14.429  -27.740 32.293  1.00 57.40  ?  281 PRO B CG  1 
ATOM   4249 C CD  . PRO B 1 287 ? 15.829  -27.154 32.137  1.00 65.33  ?  281 PRO B CD  1 
ATOM   4250 N N   . GLY B 1 288 ? 15.811  -31.317 29.703  1.00 55.72  ?  282 GLY B N   1 
ATOM   4251 C CA  . GLY B 1 288 ? 16.159  -32.095 28.530  1.00 52.16  ?  282 GLY B CA  1 
ATOM   4252 C C   . GLY B 1 288 ? 16.830  -33.426 28.856  1.00 58.78  ?  282 GLY B C   1 
ATOM   4253 O O   . GLY B 1 288 ? 17.133  -33.738 30.024  1.00 52.27  ?  282 GLY B O   1 
ATOM   4254 N N   . ALA B 1 289 ? 17.033  -34.241 27.820  1.00 55.07  ?  283 ALA B N   1 
ATOM   4255 C CA  . ALA B 1 289 ? 17.738  -35.504 27.942  1.00 58.91  ?  283 ALA B CA  1 
ATOM   4256 C C   . ALA B 1 289 ? 19.124  -35.360 27.329  1.00 63.01  ?  283 ALA B C   1 
ATOM   4257 O O   . ALA B 1 289 ? 19.277  -34.802 26.235  1.00 64.30  ?  283 ALA B O   1 
ATOM   4258 C CB  . ALA B 1 289 ? 16.991  -36.649 27.251  1.00 53.28  ?  283 ALA B CB  1 
ATOM   4259 N N   . TYR B 1 290 ? 20.129  -35.892 28.019  1.00 57.32  ?  284 TYR B N   1 
ATOM   4260 C CA  . TYR B 1 290 ? 21.505  -35.784 27.569  1.00 57.31  ?  284 TYR B CA  1 
ATOM   4261 C C   . TYR B 1 290 ? 22.187  -37.131 27.636  1.00 56.48  ?  284 TYR B C   1 
ATOM   4262 O O   . TYR B 1 290 ? 21.996  -37.891 28.592  1.00 55.43  ?  284 TYR B O   1 
ATOM   4263 C CB  . TYR B 1 290 ? 22.302  -34.824 28.426  1.00 56.83  ?  284 TYR B CB  1 
ATOM   4264 C CG  . TYR B 1 290 ? 21.683  -33.477 28.596  1.00 57.84  ?  284 TYR B CG  1 
ATOM   4265 C CD1 . TYR B 1 290 ? 20.681  -33.265 29.544  1.00 57.94  ?  284 TYR B CD1 1 
ATOM   4266 C CD2 . TYR B 1 290 ? 22.120  -32.397 27.840  1.00 58.92  ?  284 TYR B CD2 1 
ATOM   4267 C CE1 . TYR B 1 290 ? 20.119  -32.026 29.721  1.00 53.90  ?  284 TYR B CE1 1 
ATOM   4268 C CE2 . TYR B 1 290 ? 21.561  -31.143 28.015  1.00 56.86  ?  284 TYR B CE2 1 
ATOM   4269 C CZ  . TYR B 1 290 ? 20.559  -30.965 28.956  1.00 59.46  ?  284 TYR B CZ  1 
ATOM   4270 O OH  . TYR B 1 290 ? 19.995  -29.710 29.140  1.00 63.92  ?  284 TYR B OH  1 
ATOM   4271 N N   . THR B 1 291 ? 23.000  -37.408 26.630  1.00 56.43  ?  285 THR B N   1 
ATOM   4272 C CA  . THR B 1 291 ? 24.032  -38.417 26.778  1.00 51.95  ?  285 THR B CA  1 
ATOM   4273 C C   . THR B 1 291 ? 25.249  -37.759 27.413  1.00 51.02  ?  285 THR B C   1 
ATOM   4274 O O   . THR B 1 291 ? 25.240  -36.576 27.764  1.00 61.13  ?  285 THR B O   1 
ATOM   4275 C CB  . THR B 1 291 ? 24.391  -39.047 25.441  1.00 53.45  ?  285 THR B CB  1 
ATOM   4276 O OG1 . THR B 1 291 ? 25.086  -38.082 24.650  1.00 52.87  ?  285 THR B OG1 1 
ATOM   4277 C CG2 . THR B 1 291 ? 23.146  -39.548 24.726  1.00 58.76  ?  285 THR B CG2 1 
ATOM   4278 N N   . MET B 1 292 ? 26.330  -38.510 27.526  1.00 52.63  ?  286 MET B N   1 
ATOM   4279 C CA  . MET B 1 292 ? 27.497  -38.041 28.246  1.00 53.65  ?  286 MET B CA  1 
ATOM   4280 C C   . MET B 1 292 ? 28.412  -37.190 27.388  1.00 52.75  ?  286 MET B C   1 
ATOM   4281 O O   . MET B 1 292 ? 29.169  -36.384 27.937  1.00 56.30  ?  286 MET B O   1 
ATOM   4282 C CB  . MET B 1 292 ? 28.269  -39.234 28.820  1.00 54.11  ?  286 MET B CB  1 
ATOM   4283 C CG  . MET B 1 292 ? 27.897  -39.502 30.278  1.00 59.30  ?  286 MET B CG  1 
ATOM   4284 S SD  . MET B 1 292 ? 28.759  -40.862 31.122  1.00 54.15  ?  286 MET B SD  1 
ATOM   4285 C CE  . MET B 1 292 ? 29.375  -39.848 32.482  1.00 48.09  ?  286 MET B CE  1 
ATOM   4286 N N   . ILE B 1 293 ? 28.351  -37.314 26.065  1.00 48.21  ?  287 ILE B N   1 
ATOM   4287 C CA  . ILE B 1 293 ? 29.179  -36.451 25.233  1.00 46.20  ?  287 ILE B CA  1 
ATOM   4288 C C   . ILE B 1 293 ? 28.474  -35.113 25.016  1.00 52.02  ?  287 ILE B C   1 
ATOM   4289 O O   . ILE B 1 293 ? 28.931  -34.270 24.231  1.00 53.90  ?  287 ILE B O   1 
ATOM   4290 C CB  . ILE B 1 293 ? 29.543  -37.134 23.903  1.00 50.77  ?  287 ILE B CB  1 
ATOM   4291 C CG1 . ILE B 1 293 ? 28.307  -37.577 23.125  1.00 49.37  ?  287 ILE B CG1 1 
ATOM   4292 C CG2 . ILE B 1 293 ? 30.414  -38.344 24.146  1.00 50.07  ?  287 ILE B CG2 1 
ATOM   4293 C CD1 . ILE B 1 293 ? 28.581  -37.699 21.642  1.00 46.78  ?  287 ILE B CD1 1 
ATOM   4294 N N   . GLU B 1 294 ? 27.390  -34.878 25.757  1.00 50.86  ?  288 GLU B N   1 
ATOM   4295 C CA  . GLU B 1 294 ? 26.643  -33.636 25.648  1.00 55.24  ?  288 GLU B CA  1 
ATOM   4296 C C   . GLU B 1 294 ? 26.742  -32.776 26.896  1.00 54.67  ?  288 GLU B C   1 
ATOM   4297 O O   . GLU B 1 294 ? 25.940  -31.853 27.059  1.00 53.71  ?  288 GLU B O   1 
ATOM   4298 C CB  . GLU B 1 294 ? 25.169  -33.923 25.353  1.00 55.78  ?  288 GLU B CB  1 
ATOM   4299 C CG  . GLU B 1 294 ? 24.876  -34.353 23.940  1.00 54.78  ?  288 GLU B CG  1 
ATOM   4300 C CD  . GLU B 1 294 ? 23.452  -34.871 23.806  1.00 65.65  ?  288 GLU B CD  1 
ATOM   4301 O OE1 . GLU B 1 294 ? 22.527  -34.023 23.756  1.00 68.49  ?  288 GLU B OE1 1 
ATOM   4302 O OE2 . GLU B 1 294 ? 23.246  -36.115 23.775  1.00 61.00  -1 288 GLU B OE2 1 
ATOM   4303 N N   . ILE B 1 295 ? 27.675  -33.061 27.795  1.00 55.40  ?  289 ILE B N   1 
ATOM   4304 C CA  . ILE B 1 295 ? 27.722  -32.338 29.061  1.00 51.21  ?  289 ILE B CA  1 
ATOM   4305 C C   . ILE B 1 295 ? 29.158  -31.919 29.345  1.00 55.44  ?  289 ILE B C   1 
ATOM   4306 O O   . ILE B 1 295 ? 30.083  -32.740 29.220  1.00 56.76  ?  289 ILE B O   1 
ATOM   4307 C CB  . ILE B 1 295 ? 27.142  -33.196 30.191  1.00 56.60  ?  289 ILE B CB  1 
ATOM   4308 C CG1 . ILE B 1 295 ? 25.617  -33.175 30.129  1.00 56.97  ?  289 ILE B CG1 1 
ATOM   4309 C CG2 . ILE B 1 295 ? 27.585  -32.689 31.541  1.00 58.41  ?  289 ILE B CG2 1 
ATOM   4310 C CD1 . ILE B 1 295 ? 24.960  -33.752 31.361  1.00 58.62  ?  289 ILE B CD1 1 
ATOM   4311 N N   . PRO B 1 296 ? 29.396  -30.656 29.699  1.00 62.35  ?  290 PRO B N   1 
ATOM   4312 C CA  . PRO B 1 296 ? 30.752  -30.235 30.070  1.00 55.80  ?  290 PRO B CA  1 
ATOM   4313 C C   . PRO B 1 296 ? 31.334  -31.187 31.111  1.00 56.15  ?  290 PRO B C   1 
ATOM   4314 O O   . PRO B 1 296 ? 30.702  -31.480 32.134  1.00 51.98  ?  290 PRO B O   1 
ATOM   4315 C CB  . PRO B 1 296 ? 30.541  -28.818 30.633  1.00 47.99  ?  290 PRO B CB  1 
ATOM   4316 C CG  . PRO B 1 296 ? 29.299  -28.349 30.020  1.00 47.08  ?  290 PRO B CG  1 
ATOM   4317 C CD  . PRO B 1 296 ? 28.420  -29.560 29.861  1.00 56.49  ?  290 PRO B CD  1 
ATOM   4318 N N   . ILE B 1 297 ? 32.539  -31.698 30.834  1.00 54.84  ?  291 ILE B N   1 
ATOM   4319 C CA  . ILE B 1 297 ? 33.152  -32.638 31.767  1.00 56.10  ?  291 ILE B CA  1 
ATOM   4320 C C   . ILE B 1 297 ? 33.138  -32.068 33.184  1.00 54.19  ?  291 ILE B C   1 
ATOM   4321 O O   . ILE B 1 297 ? 32.897  -32.796 34.161  1.00 46.82  ?  291 ILE B O   1 
ATOM   4322 C CB  . ILE B 1 297 ? 34.582  -32.999 31.312  1.00 54.61  ?  291 ILE B CB  1 
ATOM   4323 C CG1 . ILE B 1 297 ? 34.545  -33.829 30.022  1.00 52.70  ?  291 ILE B CG1 1 
ATOM   4324 C CG2 . ILE B 1 297 ? 35.310  -33.799 32.383  1.00 46.20  ?  291 ILE B CG2 1 
ATOM   4325 C CD1 . ILE B 1 297 ? 35.897  -33.940 29.341  1.00 45.72  ?  291 ILE B CD1 1 
ATOM   4326 N N   . ILE B 1 298 ? 33.344  -30.747 33.313  1.00 52.60  ?  292 ILE B N   1 
ATOM   4327 C CA  . ILE B 1 298 ? 33.461  -30.158 34.647  1.00 54.20  ?  292 ILE B CA  1 
ATOM   4328 C C   . ILE B 1 298 ? 32.184  -30.346 35.448  1.00 52.67  ?  292 ILE B C   1 
ATOM   4329 O O   . ILE B 1 298 ? 32.236  -30.457 36.678  1.00 56.88  ?  292 ILE B O   1 
ATOM   4330 C CB  . ILE B 1 298 ? 33.855  -28.671 34.582  1.00 53.40  ?  292 ILE B CB  1 
ATOM   4331 C CG1 . ILE B 1 298 ? 34.371  -28.228 35.956  1.00 55.04  ?  292 ILE B CG1 1 
ATOM   4332 C CG2 . ILE B 1 298 ? 32.685  -27.824 34.135  1.00 50.16  ?  292 ILE B CG2 1 
ATOM   4333 C CD1 . ILE B 1 298 ? 35.207  -26.961 35.935  1.00 58.82  ?  292 ILE B CD1 1 
ATOM   4334 N N   . ASP B 1 299 ? 31.032  -30.453 34.777  1.00 49.09  ?  293 ASP B N   1 
ATOM   4335 C CA  . ASP B 1 299 ? 29.772  -30.595 35.509  1.00 53.86  ?  293 ASP B CA  1 
ATOM   4336 C C   . ASP B 1 299 ? 29.664  -31.903 36.287  1.00 54.66  ?  293 ASP B C   1 
ATOM   4337 O O   . ASP B 1 299 ? 28.825  -31.989 37.187  1.00 56.96  ?  293 ASP B O   1 
ATOM   4338 C CB  . ASP B 1 299 ? 28.584  -30.461 34.552  1.00 52.35  ?  293 ASP B CB  1 
ATOM   4339 C CG  . ASP B 1 299 ? 28.421  -29.027 34.019  1.00 55.73  ?  293 ASP B CG  1 
ATOM   4340 O OD1 . ASP B 1 299 ? 29.063  -28.082 34.563  1.00 49.51  ?  293 ASP B OD1 1 
ATOM   4341 O OD2 . ASP B 1 299 ? 27.662  -28.853 33.038  1.00 60.49  -1 293 ASP B OD2 1 
ATOM   4342 N N   . PHE B 1 300 ? 30.485  -32.913 35.982  1.00 48.54  ?  294 PHE B N   1 
ATOM   4343 C CA  . PHE B 1 300 ? 30.435  -34.163 36.730  1.00 52.32  ?  294 PHE B CA  1 
ATOM   4344 C C   . PHE B 1 300 ? 31.263  -34.123 38.003  1.00 55.03  ?  294 PHE B C   1 
ATOM   4345 O O   . PHE B 1 300 ? 31.266  -35.111 38.747  1.00 51.79  ?  294 PHE B O   1 
ATOM   4346 C CB  . PHE B 1 300 ? 30.927  -35.344 35.881  1.00 52.39  ?  294 PHE B CB  1 
ATOM   4347 C CG  . PHE B 1 300 ? 30.064  -35.658 34.667  1.00 54.47  ?  294 PHE B CG  1 
ATOM   4348 C CD1 . PHE B 1 300 ? 28.917  -36.426 34.789  1.00 50.96  ?  294 PHE B CD1 1 
ATOM   4349 C CD2 . PHE B 1 300 ? 30.440  -35.225 33.398  1.00 49.23  ?  294 PHE B CD2 1 
ATOM   4350 C CE1 . PHE B 1 300 ? 28.154  -36.734 33.672  1.00 50.47  ?  294 PHE B CE1 1 
ATOM   4351 C CE2 . PHE B 1 300 ? 29.678  -35.525 32.287  1.00 50.19  ?  294 PHE B CE2 1 
ATOM   4352 C CZ  . PHE B 1 300 ? 28.535  -36.280 32.418  1.00 48.18  ?  294 PHE B CZ  1 
ATOM   4353 N N   . LEU B 1 301 ? 31.965  -33.027 38.279  1.00 52.69  ?  295 LEU B N   1 
ATOM   4354 C CA  . LEU B 1 301 ? 32.974  -33.025 39.329  1.00 52.76  ?  295 LEU B CA  1 
ATOM   4355 C C   . LEU B 1 301 ? 32.493  -32.267 40.551  1.00 61.03  ?  295 LEU B C   1 
ATOM   4356 O O   . LEU B 1 301 ? 31.840  -31.220 40.439  1.00 61.31  ?  295 LEU B O   1 
ATOM   4357 C CB  . LEU B 1 301 ? 34.274  -32.400 38.849  1.00 53.36  ?  295 LEU B CB  1 
ATOM   4358 C CG  . LEU B 1 301 ? 35.149  -33.241 37.917  1.00 51.56  ?  295 LEU B CG  1 
ATOM   4359 C CD1 . LEU B 1 301 ? 36.280  -32.344 37.431  1.00 58.81  ?  295 LEU B CD1 1 
ATOM   4360 C CD2 . LEU B 1 301 ? 35.729  -34.425 38.621  1.00 51.59  ?  295 LEU B CD2 1 
ATOM   4361 N N   . TYR B 1 302 ? 32.829  -32.794 41.718  1.00 60.12  ?  296 TYR B N   1 
ATOM   4362 C CA  . TYR B 1 302 ? 32.525  -32.094 42.954  1.00 62.03  ?  296 TYR B CA  1 
ATOM   4363 C C   . TYR B 1 302 ? 33.472  -30.910 43.112  1.00 57.87  ?  296 TYR B C   1 
ATOM   4364 O O   . TYR B 1 302 ? 34.687  -31.053 42.977  1.00 58.35  ?  296 TYR B O   1 
ATOM   4365 C CB  . TYR B 1 302 ? 32.641  -33.057 44.143  1.00 60.77  ?  296 TYR B CB  1 
ATOM   4366 C CG  . TYR B 1 302 ? 32.534  -32.397 45.507  1.00 67.07  ?  296 TYR B CG  1 
ATOM   4367 C CD1 . TYR B 1 302 ? 31.340  -31.815 45.927  1.00 67.86  ?  296 TYR B CD1 1 
ATOM   4368 C CD2 . TYR B 1 302 ? 33.627  -32.359 46.378  1.00 64.72  ?  296 TYR B CD2 1 
ATOM   4369 C CE1 . TYR B 1 302 ? 31.239  -31.210 47.166  1.00 66.48  ?  296 TYR B CE1 1 
ATOM   4370 C CE2 . TYR B 1 302 ? 33.534  -31.762 47.620  1.00 60.39  ?  296 TYR B CE2 1 
ATOM   4371 C CZ  . TYR B 1 302 ? 32.332  -31.196 48.009  1.00 69.82  ?  296 TYR B CZ  1 
ATOM   4372 O OH  . TYR B 1 302 ? 32.210  -30.592 49.236  1.00 78.99  ?  296 TYR B OH  1 
ATOM   4373 N N   . GLY B 1 303 ? 32.922  -29.732 43.368  1.00 63.22  ?  297 GLY B N   1 
ATOM   4374 C CA  . GLY B 1 303 ? 33.730  -28.617 43.818  1.00 61.37  ?  297 GLY B CA  1 
ATOM   4375 C C   . GLY B 1 303 ? 33.397  -27.314 43.116  1.00 62.76  ?  297 GLY B C   1 
ATOM   4376 O O   . GLY B 1 303 ? 32.623  -27.251 42.158  1.00 56.01  ?  297 GLY B O   1 
ATOM   4377 N N   . ASP B 1 304 ? 34.012  -26.255 43.646  1.00 65.51  ?  298 ASP B N   1 
ATOM   4378 C CA  . ASP B 1 304 ? 33.998  -24.938 43.028  1.00 70.19  ?  298 ASP B CA  1 
ATOM   4379 C C   . ASP B 1 304 ? 34.610  -24.988 41.631  1.00 68.44  ?  298 ASP B C   1 
ATOM   4380 O O   . ASP B 1 304 ? 35.647  -25.623 41.420  1.00 70.13  ?  298 ASP B O   1 
ATOM   4381 C CB  . ASP B 1 304 ? 34.788  -23.966 43.908  1.00 71.10  ?  298 ASP B CB  1 
ATOM   4382 C CG  . ASP B 1 304 ? 35.324  -22.785 43.128  1.00 77.76  ?  298 ASP B CG  1 
ATOM   4383 O OD1 . ASP B 1 304 ? 34.560  -21.824 42.832  1.00 80.55  ?  298 ASP B OD1 1 
ATOM   4384 O OD2 . ASP B 1 304 ? 36.524  -22.846 42.781  1.00 77.87  -1 298 ASP B OD2 1 
ATOM   4385 N N   . ARG B 1 305 ? 33.970  -24.304 40.675  1.00 60.70  ?  299 ARG B N   1 
ATOM   4386 C CA  . ARG B 1 305 ? 34.482  -24.278 39.303  1.00 68.29  ?  299 ARG B CA  1 
ATOM   4387 C C   . ARG B 1 305 ? 35.961  -23.883 39.239  1.00 72.48  ?  299 ARG B C   1 
ATOM   4388 O O   . ARG B 1 305 ? 36.815  -24.689 38.840  1.00 68.41  ?  299 ARG B O   1 
ATOM   4389 C CB  . ARG B 1 305 ? 33.645  -23.325 38.454  1.00 65.99  ?  299 ARG B CB  1 
ATOM   4390 C CG  . ARG B 1 305 ? 33.786  -23.539 36.966  1.00 67.59  ?  299 ARG B CG  1 
ATOM   4391 C CD  . ARG B 1 305 ? 32.595  -22.927 36.236  1.00 78.85  ?  299 ARG B CD  1 
ATOM   4392 N NE  . ARG B 1 305 ? 31.568  -23.919 35.917  1.00 72.15  ?  299 ARG B NE  1 
ATOM   4393 C CZ  . ARG B 1 305 ? 31.267  -24.315 34.687  1.00 71.23  ?  299 ARG B CZ  1 
ATOM   4394 N NH1 . ARG B 1 305 ? 31.838  -23.759 33.627  1.00 69.72  ?  299 ARG B NH1 1 
ATOM   4395 N NH2 . ARG B 1 305 ? 30.354  -25.281 34.513  1.00 69.47  ?  299 ARG B NH2 1 
ATOM   4396 N N   . ASP B 1 306 ? 36.274  -22.636 39.633  1.00 71.52  ?  300 ASP B N   1 
ATOM   4397 C CA  . ASP B 1 306 ? 37.625  -22.098 39.480  1.00 69.97  ?  300 ASP B CA  1 
ATOM   4398 C C   . ASP B 1 306 ? 38.679  -23.008 40.103  1.00 69.77  ?  300 ASP B C   1 
ATOM   4399 O O   . ASP B 1 306 ? 39.778  -23.168 39.551  1.00 67.52  ?  300 ASP B O   1 
ATOM   4400 C CB  . ASP B 1 306 ? 37.713  -20.692 40.089  1.00 66.11  ?  300 ASP B CB  1 
ATOM   4401 C CG  . ASP B 1 306 ? 37.203  -19.604 39.142  1.00 69.19  ?  300 ASP B CG  1 
ATOM   4402 O OD1 . ASP B 1 306 ? 36.691  -19.959 38.062  1.00 72.73  ?  300 ASP B OD1 1 
ATOM   4403 O OD2 . ASP B 1 306 ? 37.297  -18.392 39.471  1.00 69.02  -1 300 ASP B OD2 1 
ATOM   4404 N N   . GLU B 1 307 ? 38.363  -23.628 41.242  1.00 69.75  ?  301 GLU B N   1 
ATOM   4405 C CA  . GLU B 1 307 ? 39.353  -24.477 41.899  1.00 67.77  ?  301 GLU B CA  1 
ATOM   4406 C C   . GLU B 1 307 ? 39.598  -25.755 41.108  1.00 71.18  ?  301 GLU B C   1 
ATOM   4407 O O   . GLU B 1 307 ? 40.741  -26.216 40.997  1.00 74.81  ?  301 GLU B O   1 
ATOM   4408 C CB  . GLU B 1 307 ? 38.914  -24.799 43.327  1.00 71.70  ?  301 GLU B CB  1 
ATOM   4409 C CG  . GLU B 1 307 ? 40.064  -25.203 44.273  1.00 83.96  ?  301 GLU B CG  1 
ATOM   4410 C CD  . GLU B 1 307 ? 41.349  -24.356 44.114  1.00 90.05  ?  301 GLU B CD  1 
ATOM   4411 O OE1 . GLU B 1 307 ? 41.266  -23.098 44.033  1.00 87.94  ?  301 GLU B OE1 1 
ATOM   4412 O OE2 . GLU B 1 307 ? 42.448  -24.964 44.058  1.00 86.68  -1 301 GLU B OE2 1 
ATOM   4413 N N   . LEU B 1 308 ? 38.540  -26.346 40.553  1.00 64.13  ?  302 LEU B N   1 
ATOM   4414 C CA  . LEU B 1 308 ? 38.716  -27.511 39.696  1.00 67.18  ?  302 LEU B CA  1 
ATOM   4415 C C   . LEU B 1 308 ? 39.591  -27.188 38.490  1.00 64.06  ?  302 LEU B C   1 
ATOM   4416 O O   . LEU B 1 308 ? 40.432  -28.001 38.085  1.00 59.31  ?  302 LEU B O   1 
ATOM   4417 C CB  . LEU B 1 308 ? 37.352  -28.022 39.242  1.00 63.44  ?  302 LEU B CB  1 
ATOM   4418 C CG  . LEU B 1 308 ? 36.520  -28.565 40.394  1.00 62.32  ?  302 LEU B CG  1 
ATOM   4419 C CD1 . LEU B 1 308 ? 35.093  -28.730 39.939  1.00 62.50  ?  302 LEU B CD1 1 
ATOM   4420 C CD2 . LEU B 1 308 ? 37.108  -29.881 40.883  1.00 61.07  ?  302 LEU B CD2 1 
ATOM   4421 N N   . ILE B 1 309 ? 39.401  -26.008 37.899  1.00 61.21  ?  303 ILE B N   1 
ATOM   4422 C CA  . ILE B 1 309 ? 40.177  -25.639 36.720  1.00 65.71  ?  303 ILE B CA  1 
ATOM   4423 C C   . ILE B 1 309 ? 41.667  -25.565 37.058  1.00 67.02  ?  303 ILE B C   1 
ATOM   4424 O O   . ILE B 1 309 ? 42.505  -26.218 36.416  1.00 62.54  ?  303 ILE B O   1 
ATOM   4425 C CB  . ILE B 1 309 ? 39.654  -24.316 36.135  1.00 62.89  ?  303 ILE B CB  1 
ATOM   4426 C CG1 . ILE B 1 309 ? 38.318  -24.562 35.445  1.00 60.01  ?  303 ILE B CG1 1 
ATOM   4427 C CG2 . ILE B 1 309 ? 40.648  -23.726 35.159  1.00 54.38  ?  303 ILE B CG2 1 
ATOM   4428 C CD1 . ILE B 1 309 ? 37.721  -23.321 34.846  1.00 69.92  ?  303 ILE B CD1 1 
ATOM   4429 N N   . ARG B 1 310 ? 42.021  -24.794 38.090  1.00 67.10  ?  304 ARG B N   1 
ATOM   4430 C CA  . ARG B 1 310 ? 43.440  -24.593 38.366  1.00 68.45  ?  304 ARG B CA  1 
ATOM   4431 C C   . ARG B 1 310 ? 44.106  -25.882 38.817  1.00 67.27  ?  304 ARG B C   1 
ATOM   4432 O O   . ARG B 1 310 ? 45.286  -26.105 38.522  1.00 75.03  ?  304 ARG B O   1 
ATOM   4433 C CB  . ARG B 1 310 ? 43.633  -23.468 39.391  1.00 74.09  ?  304 ARG B CB  1 
ATOM   4434 C CG  . ARG B 1 310 ? 43.396  -23.815 40.850  1.00 76.17  ?  304 ARG B CG  1 
ATOM   4435 C CD  . ARG B 1 310 ? 44.034  -22.756 41.754  1.00 81.44  ?  304 ARG B CD  1 
ATOM   4436 N NE  . ARG B 1 310 ? 43.669  -21.394 41.358  1.00 86.16  ?  304 ARG B NE  1 
ATOM   4437 C CZ  . ARG B 1 310 ? 42.584  -20.753 41.782  1.00 84.78  ?  304 ARG B CZ  1 
ATOM   4438 N NH1 . ARG B 1 310 ? 41.727  -21.322 42.623  1.00 76.69  ?  304 ARG B NH1 1 
ATOM   4439 N NH2 . ARG B 1 310 ? 42.347  -19.515 41.344  1.00 78.64  ?  304 ARG B NH2 1 
ATOM   4440 N N   . ARG B 1 311 ? 43.366  -26.764 39.474  1.00 64.72  ?  305 ARG B N   1 
ATOM   4441 C CA  . ARG B 1 311 ? 43.946  -28.039 39.876  1.00 67.60  ?  305 ARG B CA  1 
ATOM   4442 C C   . ARG B 1 311 ? 44.023  -29.050 38.734  1.00 64.19  ?  305 ARG B C   1 
ATOM   4443 O O   . ARG B 1 311 ? 44.844  -29.966 38.801  1.00 62.88  ?  305 ARG B O   1 
ATOM   4444 C CB  . ARG B 1 311 ? 43.147  -28.629 41.044  1.00 66.65  ?  305 ARG B CB  1 
ATOM   4445 C CG  . ARG B 1 311 ? 43.549  -30.037 41.430  1.00 70.49  ?  305 ARG B CG  1 
ATOM   4446 C CD  . ARG B 1 311 ? 42.866  -30.475 42.691  1.00 75.18  ?  305 ARG B CD  1 
ATOM   4447 N NE  . ARG B 1 311 ? 41.417  -30.518 42.549  1.00 71.94  ?  305 ARG B NE  1 
ATOM   4448 C CZ  . ARG B 1 311 ? 40.747  -31.624 42.269  1.00 76.23  ?  305 ARG B CZ  1 
ATOM   4449 N NH1 . ARG B 1 311 ? 41.377  -32.757 42.004  1.00 73.55  ?  305 ARG B NH1 1 
ATOM   4450 N NH2 . ARG B 1 311 ? 39.417  -31.597 42.273  1.00 69.81  ?  305 ARG B NH2 1 
ATOM   4451 N N   . LEU B 1 312 ? 43.211  -28.913 37.684  1.00 62.79  ?  306 LEU B N   1 
ATOM   4452 C CA  . LEU B 1 312 ? 43.121  -29.976 36.695  1.00 62.33  ?  306 LEU B CA  1 
ATOM   4453 C C   . LEU B 1 312 ? 43.472  -29.567 35.270  1.00 64.46  ?  306 LEU B C   1 
ATOM   4454 O O   . LEU B 1 312 ? 43.918  -30.421 34.493  1.00 60.15  ?  306 LEU B O   1 
ATOM   4455 C CB  . LEU B 1 312 ? 41.718  -30.569 36.684  1.00 54.99  ?  306 LEU B CB  1 
ATOM   4456 C CG  . LEU B 1 312 ? 41.334  -31.553 37.781  1.00 63.93  ?  306 LEU B CG  1 
ATOM   4457 C CD1 . LEU B 1 312 ? 39.829  -31.631 37.769  1.00 56.06  ?  306 LEU B CD1 1 
ATOM   4458 C CD2 . LEU B 1 312 ? 41.950  -32.944 37.577  1.00 55.49  ?  306 LEU B CD2 1 
ATOM   4459 N N   . VAL B 1 313 ? 43.275  -28.311 34.893  1.00 63.72  ?  307 VAL B N   1 
ATOM   4460 C CA  . VAL B 1 313 ? 43.402  -27.958 33.485  1.00 64.68  ?  307 VAL B CA  1 
ATOM   4461 C C   . VAL B 1 313 ? 44.847  -27.676 33.150  1.00 69.05  ?  307 VAL B C   1 
ATOM   4462 O O   . VAL B 1 313 ? 45.436  -28.330 32.290  1.00 74.32  ?  307 VAL B O   1 
ATOM   4463 C CB  . VAL B 1 313 ? 42.514  -26.766 33.130  1.00 63.97  ?  307 VAL B CB  1 
ATOM   4464 C CG1 . VAL B 1 313 ? 42.878  -26.228 31.757  1.00 56.17  ?  307 VAL B CG1 1 
ATOM   4465 C CG2 . VAL B 1 313 ? 41.040  -27.173 33.216  1.00 54.87  ?  307 VAL B CG2 1 
ATOM   4466 O OXT . VAL B 1 313 ? 45.466  -26.795 33.740  1.00 76.40  -1 307 VAL B OXT 1 
ATOM   4467 N N   . ARG C 1 11  ? 8.465   -52.163 28.618  1.00 86.38  ?  5   ARG C N   1 
ATOM   4468 C CA  . ARG C 1 11  ? 8.826   -51.144 27.635  1.00 87.73  ?  5   ARG C CA  1 
ATOM   4469 C C   . ARG C 1 11  ? 7.809   -49.991 27.645  1.00 88.39  ?  5   ARG C C   1 
ATOM   4470 O O   . ARG C 1 11  ? 8.085   -48.934 28.208  1.00 86.48  ?  5   ARG C O   1 
ATOM   4471 C CB  . ARG C 1 11  ? 8.946   -51.757 26.228  1.00 82.25  ?  5   ARG C CB  1 
ATOM   4472 C CG  . ARG C 1 11  ? 10.323  -51.559 25.581  1.00 93.10  ?  5   ARG C CG  1 
ATOM   4473 C CD  . ARG C 1 11  ? 10.621  -52.636 24.539  1.00 97.78  ?  5   ARG C CD  1 
ATOM   4474 N NE  . ARG C 1 11  ? 11.588  -52.202 23.533  1.00 110.30 ?  5   ARG C NE  1 
ATOM   4475 C CZ  . ARG C 1 11  ? 11.831  -52.852 22.399  1.00 111.26 ?  5   ARG C CZ  1 
ATOM   4476 N NH1 . ARG C 1 11  ? 11.202  -53.979 22.103  1.00 102.31 ?  5   ARG C NH1 1 
ATOM   4477 N NH2 . ARG C 1 11  ? 12.729  -52.361 21.543  1.00 103.89 ?  5   ARG C NH2 1 
ATOM   4478 N N   . THR C 1 12  ? 6.631   -50.207 27.055  1.00 90.01  ?  6   THR C N   1 
ATOM   4479 C CA  . THR C 1 12  ? 5.637   -49.151 26.898  1.00 86.69  ?  6   THR C CA  1 
ATOM   4480 C C   . THR C 1 12  ? 5.167   -48.610 28.258  1.00 85.09  ?  6   THR C C   1 
ATOM   4481 O O   . THR C 1 12  ? 5.532   -49.104 29.323  1.00 85.16  ?  6   THR C O   1 
ATOM   4482 C CB  . THR C 1 12  ? 4.449   -49.664 26.084  1.00 93.00  ?  6   THR C CB  1 
ATOM   4483 O OG1 . THR C 1 12  ? 3.365   -48.729 26.175  1.00 90.91  ?  6   THR C OG1 1 
ATOM   4484 C CG2 . THR C 1 12  ? 3.996   -51.050 26.586  1.00 91.70  ?  6   THR C CG2 1 
ATOM   4485 N N   . GLU C 1 13  ? 4.342   -47.569 28.205  1.00 90.49  ?  7   GLU C N   1 
ATOM   4486 C CA  . GLU C 1 13  ? 3.959   -46.814 29.390  1.00 85.87  ?  7   GLU C CA  1 
ATOM   4487 C C   . GLU C 1 13  ? 2.722   -47.427 30.052  1.00 86.43  ?  7   GLU C C   1 
ATOM   4488 O O   . GLU C 1 13  ? 1.917   -48.113 29.413  1.00 90.10  ?  7   GLU C O   1 
ATOM   4489 C CB  . GLU C 1 13  ? 3.679   -45.354 29.020  1.00 86.17  ?  7   GLU C CB  1 
ATOM   4490 C CG  . GLU C 1 13  ? 4.906   -44.441 29.000  1.00 92.46  ?  7   GLU C CG  1 
ATOM   4491 C CD  . GLU C 1 13  ? 5.228   -43.816 30.368  1.00 97.21  ?  7   GLU C CD  1 
ATOM   4492 O OE1 . GLU C 1 13  ? 5.681   -44.578 31.260  1.00 95.13  ?  7   GLU C OE1 1 
ATOM   4493 O OE2 . GLU C 1 13  ? 5.050   -42.574 30.550  1.00 88.93  -1 7   GLU C OE2 1 
ATOM   4494 N N   . ARG C 1 14  ? 2.578   -47.170 31.355  1.00 80.90  ?  8   ARG C N   1 
ATOM   4495 C CA  . ARG C 1 14  ? 1.421   -47.672 32.085  1.00 76.14  ?  8   ARG C CA  1 
ATOM   4496 C C   . ARG C 1 14  ? 0.173   -46.875 31.702  1.00 77.93  ?  8   ARG C C   1 
ATOM   4497 O O   . ARG C 1 14  ? 0.254   -45.670 31.460  1.00 79.58  ?  8   ARG C O   1 
ATOM   4498 C CB  . ARG C 1 14  ? 1.651   -47.592 33.606  1.00 70.95  ?  8   ARG C CB  1 
ATOM   4499 C CG  . ARG C 1 14  ? 1.924   -46.178 34.130  1.00 79.88  ?  8   ARG C CG  1 
ATOM   4500 C CD  . ARG C 1 14  ? 1.815   -46.042 35.657  1.00 78.64  ?  8   ARG C CD  1 
ATOM   4501 N NE  . ARG C 1 14  ? 0.469   -45.694 36.103  1.00 80.27  ?  8   ARG C NE  1 
ATOM   4502 C CZ  . ARG C 1 14  ? 0.060   -44.485 36.477  1.00 83.70  ?  8   ARG C CZ  1 
ATOM   4503 N NH1 . ARG C 1 14  ? 0.867   -43.435 36.445  1.00 86.96  ?  8   ARG C NH1 1 
ATOM   4504 N NH2 . ARG C 1 14  ? -1.196  -44.325 36.893  1.00 85.00  ?  8   ARG C NH2 1 
ATOM   4505 N N   . PRO C 1 15  ? -0.992  -47.514 31.637  1.00 78.61  ?  9   PRO C N   1 
ATOM   4506 C CA  . PRO C 1 15  ? -2.229  -46.774 31.349  1.00 74.63  ?  9   PRO C CA  1 
ATOM   4507 C C   . PRO C 1 15  ? -2.432  -45.606 32.303  1.00 75.14  ?  9   PRO C C   1 
ATOM   4508 O O   . PRO C 1 15  ? -2.019  -45.652 33.463  1.00 78.06  ?  9   PRO C O   1 
ATOM   4509 C CB  . PRO C 1 15  ? -3.318  -47.831 31.534  1.00 69.94  ?  9   PRO C CB  1 
ATOM   4510 C CG  . PRO C 1 15  ? -2.630  -49.109 31.224  1.00 71.50  ?  9   PRO C CG  1 
ATOM   4511 C CD  . PRO C 1 15  ? -1.208  -48.969 31.671  1.00 68.67  ?  9   PRO C CD  1 
ATOM   4512 N N   . ILE C 1 16  ? -3.062  -44.542 31.795  1.00 75.33  ?  10  ILE C N   1 
ATOM   4513 C CA  . ILE C 1 16  ? -3.584  -43.487 32.663  1.00 72.07  ?  10  ILE C CA  1 
ATOM   4514 C C   . ILE C 1 16  ? -4.861  -43.989 33.321  1.00 66.91  ?  10  ILE C C   1 
ATOM   4515 O O   . ILE C 1 16  ? -5.759  -44.519 32.653  1.00 66.20  ?  10  ILE C O   1 
ATOM   4516 C CB  . ILE C 1 16  ? -3.844  -42.188 31.884  1.00 64.57  ?  10  ILE C CB  1 
ATOM   4517 C CG1 . ILE C 1 16  ? -2.617  -41.766 31.081  1.00 71.35  ?  10  ILE C CG1 1 
ATOM   4518 C CG2 . ILE C 1 16  ? -4.191  -41.090 32.842  1.00 61.13  ?  10  ILE C CG2 1 
ATOM   4519 C CD1 . ILE C 1 16  ? -2.809  -40.475 30.305  1.00 61.40  ?  10  ILE C CD1 1 
ATOM   4520 N N   . ARG C 1 17  ? -4.944  -43.833 34.633  1.00 67.78  ?  11  ARG C N   1 
ATOM   4521 C CA  . ARG C 1 17  ? -6.067  -44.347 35.399  1.00 69.53  ?  11  ARG C CA  1 
ATOM   4522 C C   . ARG C 1 17  ? -7.048  -43.213 35.630  1.00 71.15  ?  11  ARG C C   1 
ATOM   4523 O O   . ARG C 1 17  ? -6.703  -42.214 36.282  1.00 70.95  ?  11  ARG C O   1 
ATOM   4524 C CB  . ARG C 1 17  ? -5.594  -44.954 36.718  1.00 69.76  ?  11  ARG C CB  1 
ATOM   4525 C CG  . ARG C 1 17  ? -4.536  -46.006 36.503  1.00 70.37  ?  11  ARG C CG  1 
ATOM   4526 C CD  . ARG C 1 17  ? -4.987  -47.340 36.999  1.00 67.23  ?  11  ARG C CD  1 
ATOM   4527 N NE  . ARG C 1 17  ? -5.956  -47.230 38.082  1.00 71.77  ?  11  ARG C NE  1 
ATOM   4528 C CZ  . ARG C 1 17  ? -6.794  -48.205 38.410  1.00 70.63  ?  11  ARG C CZ  1 
ATOM   4529 N NH1 . ARG C 1 17  ? -6.814  -49.348 37.743  1.00 62.57  ?  11  ARG C NH1 1 
ATOM   4530 N NH2 . ARG C 1 17  ? -7.628  -48.031 39.433  1.00 69.46  ?  11  ARG C NH2 1 
ATOM   4531 N N   . VAL C 1 18  ? -8.254  -43.360 35.072  1.00 60.22  ?  12  VAL C N   1 
ATOM   4532 C CA  . VAL C 1 18  ? -9.264  -42.312 35.071  1.00 62.39  ?  12  VAL C CA  1 
ATOM   4533 C C   . VAL C 1 18  ? -10.442 -42.766 35.920  1.00 74.03  ?  12  VAL C C   1 
ATOM   4534 O O   . VAL C 1 18  ? -10.886 -43.920 35.831  1.00 72.69  ?  12  VAL C O   1 
ATOM   4535 C CB  . VAL C 1 18  ? -9.731  -41.973 33.639  1.00 62.36  ?  12  VAL C CB  1 
ATOM   4536 C CG1 . VAL C 1 18  ? -10.865 -40.968 33.660  1.00 58.80  ?  12  VAL C CG1 1 
ATOM   4537 C CG2 . VAL C 1 18  ? -8.578  -41.443 32.815  1.00 70.14  ?  12  VAL C CG2 1 
ATOM   4538 N N   . ALA C 1 19  ? -10.957 -41.851 36.733  1.00 72.63  ?  13  ALA C N   1 
ATOM   4539 C CA  . ALA C 1 19  ? -12.220 -42.036 37.419  1.00 65.87  ?  13  ALA C CA  1 
ATOM   4540 C C   . ALA C 1 19  ? -13.198 -41.003 36.889  1.00 69.67  ?  13  ALA C C   1 
ATOM   4541 O O   . ALA C 1 19  ? -12.841 -39.839 36.706  1.00 72.67  ?  13  ALA C O   1 
ATOM   4542 C CB  . ALA C 1 19  ? -12.058 -41.892 38.929  1.00 67.90  ?  13  ALA C CB  1 
ATOM   4543 N N   . ILE C 1 20  ? -14.428 -41.423 36.628  1.00 72.13  ?  14  ILE C N   1 
ATOM   4544 C CA  . ILE C 1 20  ? -15.473 -40.513 36.184  1.00 66.80  ?  14  ILE C CA  1 
ATOM   4545 C C   . ILE C 1 20  ? -16.326 -40.149 37.392  1.00 67.67  ?  14  ILE C C   1 
ATOM   4546 O O   . ILE C 1 20  ? -16.717 -41.030 38.165  1.00 73.93  ?  14  ILE C O   1 
ATOM   4547 C CB  . ILE C 1 20  ? -16.313 -41.145 35.064  1.00 66.70  ?  14  ILE C CB  1 
ATOM   4548 C CG1 . ILE C 1 20  ? -15.441 -41.399 33.830  1.00 61.53  ?  14  ILE C CG1 1 
ATOM   4549 C CG2 . ILE C 1 20  ? -17.509 -40.256 34.721  1.00 66.49  ?  14  ILE C CG2 1 
ATOM   4550 C CD1 . ILE C 1 20  ? -15.947 -42.517 32.929  1.00 60.21  ?  14  ILE C CD1 1 
ATOM   4551 N N   . ILE C 1 21  ? -16.616 -38.863 37.558  1.00 62.17  ?  15  ILE C N   1 
ATOM   4552 C CA  . ILE C 1 21  ? -17.308 -38.348 38.737  1.00 63.32  ?  15  ILE C CA  1 
ATOM   4553 C C   . ILE C 1 21  ? -18.668 -37.837 38.294  1.00 64.59  ?  15  ILE C C   1 
ATOM   4554 O O   . ILE C 1 21  ? -18.766 -36.775 37.670  1.00 70.45  ?  15  ILE C O   1 
ATOM   4555 C CB  . ILE C 1 21  ? -16.507 -37.235 39.429  1.00 61.76  ?  15  ILE C CB  1 
ATOM   4556 C CG1 . ILE C 1 21  ? -15.032 -37.594 39.528  1.00 68.13  ?  15  ILE C CG1 1 
ATOM   4557 C CG2 . ILE C 1 21  ? -17.028 -36.984 40.794  1.00 65.28  ?  15  ILE C CG2 1 
ATOM   4558 C CD1 . ILE C 1 21  ? -14.743 -38.721 40.500  1.00 71.79  ?  15  ILE C CD1 1 
ATOM   4559 N N   . GLY C 1 22  ? -19.721 -38.569 38.632  1.00 69.98  ?  16  GLY C N   1 
ATOM   4560 C CA  . GLY C 1 22  ? -21.066 -38.206 38.208  1.00 68.80  ?  16  GLY C CA  1 
ATOM   4561 C C   . GLY C 1 22  ? -21.525 -38.912 36.939  1.00 73.07  ?  16  GLY C C   1 
ATOM   4562 O O   . GLY C 1 22  ? -21.283 -38.429 35.827  1.00 74.59  ?  16  GLY C O   1 
ATOM   4563 N N   . TYR C 1 23  ? -22.191 -40.060 37.086  1.00 70.51  ?  17  TYR C N   1 
ATOM   4564 C CA  . TYR C 1 23  ? -22.673 -40.832 35.944  1.00 69.46  ?  17  TYR C CA  1 
ATOM   4565 C C   . TYR C 1 23  ? -23.999 -40.256 35.467  1.00 70.51  ?  17  TYR C C   1 
ATOM   4566 O O   . TYR C 1 23  ? -25.081 -40.735 35.809  1.00 78.94  ?  17  TYR C O   1 
ATOM   4567 C CB  . TYR C 1 23  ? -22.835 -42.296 36.315  1.00 74.21  ?  17  TYR C CB  1 
ATOM   4568 C CG  . TYR C 1 23  ? -22.842 -43.204 35.112  1.00 75.46  ?  17  TYR C CG  1 
ATOM   4569 C CD1 . TYR C 1 23  ? -21.677 -43.406 34.387  1.00 74.41  ?  17  TYR C CD1 1 
ATOM   4570 C CD2 . TYR C 1 23  ? -24.009 -43.846 34.686  1.00 70.20  ?  17  TYR C CD2 1 
ATOM   4571 C CE1 . TYR C 1 23  ? -21.657 -44.228 33.284  1.00 73.70  ?  17  TYR C CE1 1 
ATOM   4572 C CE2 . TYR C 1 23  ? -23.996 -44.675 33.574  1.00 72.44  ?  17  TYR C CE2 1 
ATOM   4573 C CZ  . TYR C 1 23  ? -22.807 -44.858 32.886  1.00 73.81  ?  17  TYR C CZ  1 
ATOM   4574 O OH  . TYR C 1 23  ? -22.725 -45.651 31.781  1.00 73.49  ?  17  TYR C OH  1 
ATOM   4575 N N   . GLY C 1 24  ? -23.913 -39.211 34.658  1.00 69.83  ?  18  GLY C N   1 
ATOM   4576 C CA  . GLY C 1 24  ? -25.104 -38.616 34.074  1.00 65.52  ?  18  GLY C CA  1 
ATOM   4577 C C   . GLY C 1 24  ? -25.073 -38.696 32.562  1.00 66.52  ?  18  GLY C C   1 
ATOM   4578 O O   . GLY C 1 24  ? -24.527 -39.651 32.000  1.00 68.05  ?  18  GLY C O   1 
ATOM   4579 N N   . ASN C 1 25  ? -25.633 -37.694 31.884  1.00 62.82  ?  19  ASN C N   1 
ATOM   4580 C CA  . ASN C 1 25  ? -25.630 -37.711 30.423  1.00 60.91  ?  19  ASN C CA  1 
ATOM   4581 C C   . ASN C 1 25  ? -24.196 -37.647 29.869  1.00 66.56  ?  19  ASN C C   1 
ATOM   4582 O O   . ASN C 1 25  ? -23.809 -38.458 29.014  1.00 66.25  ?  19  ASN C O   1 
ATOM   4583 C CB  . ASN C 1 25  ? -26.526 -36.574 29.919  1.00 62.20  ?  19  ASN C CB  1 
ATOM   4584 C CG  . ASN C 1 25  ? -26.217 -36.155 28.490  1.00 71.96  ?  19  ASN C CG  1 
ATOM   4585 O OD1 . ASN C 1 25  ? -26.331 -36.956 27.544  1.00 66.37  ?  19  ASN C OD1 1 
ATOM   4586 N ND2 . ASN C 1 25  ? -25.843 -34.878 28.322  1.00 65.81  ?  19  ASN C ND2 1 
ATOM   4587 N N   . ILE C 1 26  ? -23.375 -36.721 30.386  1.00 67.37  ?  20  ILE C N   1 
ATOM   4588 C CA  . ILE C 1 26  ? -21.976 -36.633 29.965  1.00 64.97  ?  20  ILE C CA  1 
ATOM   4589 C C   . ILE C 1 26  ? -21.184 -37.840 30.467  1.00 64.67  ?  20  ILE C C   1 
ATOM   4590 O O   . ILE C 1 26  ? -20.268 -38.331 29.787  1.00 62.77  ?  20  ILE C O   1 
ATOM   4591 C CB  . ILE C 1 26  ? -21.353 -35.301 30.445  1.00 60.22  ?  20  ILE C CB  1 
ATOM   4592 C CG1 . ILE C 1 26  ? -21.912 -34.132 29.649  1.00 62.27  ?  20  ILE C CG1 1 
ATOM   4593 C CG2 . ILE C 1 26  ? -19.864 -35.299 30.252  1.00 54.54  ?  20  ILE C CG2 1 
ATOM   4594 C CD1 . ILE C 1 26  ? -21.636 -34.247 28.168  1.00 63.63  ?  20  ILE C CD1 1 
ATOM   4595 N N   . GLY C 1 27  ? -21.510 -38.331 31.665  1.00 62.40  ?  21  GLY C N   1 
ATOM   4596 C CA  . GLY C 1 27  ? -20.710 -39.391 32.262  1.00 65.95  ?  21  GLY C CA  1 
ATOM   4597 C C   . GLY C 1 27  ? -20.813 -40.714 31.525  1.00 68.02  ?  21  GLY C C   1 
ATOM   4598 O O   . GLY C 1 27  ? -19.854 -41.493 31.497  1.00 63.68  ?  21  GLY C O   1 
ATOM   4599 N N   . GLN C 1 28  ? -21.970 -40.998 30.925  1.00 66.22  ?  22  GLN C N   1 
ATOM   4600 C CA  . GLN C 1 28  ? -22.068 -42.217 30.137  1.00 64.13  ?  22  GLN C CA  1 
ATOM   4601 C C   . GLN C 1 28  ? -21.202 -42.127 28.901  1.00 63.91  ?  22  GLN C C   1 
ATOM   4602 O O   . GLN C 1 28  ? -20.513 -43.091 28.547  1.00 69.43  ?  22  GLN C O   1 
ATOM   4603 C CB  . GLN C 1 28  ? -23.514 -42.494 29.744  1.00 70.42  ?  22  GLN C CB  1 
ATOM   4604 C CG  . GLN C 1 28  ? -24.473 -42.453 30.901  1.00 73.26  ?  22  GLN C CG  1 
ATOM   4605 C CD  . GLN C 1 28  ? -25.901 -42.527 30.442  1.00 79.35  ?  22  GLN C CD  1 
ATOM   4606 O OE1 . GLN C 1 28  ? -26.180 -42.823 29.275  1.00 85.93  ?  22  GLN C OE1 1 
ATOM   4607 N NE2 . GLN C 1 28  ? -26.819 -42.229 31.346  1.00 79.45  ?  22  GLN C NE2 1 
ATOM   4608 N N   . TYR C 1 29  ? -21.229 -40.980 28.223  1.00 64.59  ?  23  TYR C N   1 
ATOM   4609 C CA  . TYR C 1 29  ? -20.404 -40.821 27.033  1.00 61.27  ?  23  TYR C CA  1 
ATOM   4610 C C   . TYR C 1 29  ? -18.925 -40.827 27.387  1.00 59.77  ?  23  TYR C C   1 
ATOM   4611 O O   . TYR C 1 29  ? -18.118 -41.438 26.676  1.00 63.00  ?  23  TYR C O   1 
ATOM   4612 C CB  . TYR C 1 29  ? -20.790 -39.545 26.311  1.00 60.63  ?  23  TYR C CB  1 
ATOM   4613 C CG  . TYR C 1 29  ? -22.011 -39.686 25.425  1.00 58.74  ?  23  TYR C CG  1 
ATOM   4614 C CD1 . TYR C 1 29  ? -21.920 -40.305 24.175  1.00 55.32  ?  23  TYR C CD1 1 
ATOM   4615 C CD2 . TYR C 1 29  ? -23.250 -39.184 25.828  1.00 58.23  ?  23  TYR C CD2 1 
ATOM   4616 C CE1 . TYR C 1 29  ? -23.023 -40.422 23.341  1.00 52.02  ?  23  TYR C CE1 1 
ATOM   4617 C CE2 . TYR C 1 29  ? -24.366 -39.295 25.005  1.00 57.24  ?  23  TYR C CE2 1 
ATOM   4618 C CZ  . TYR C 1 29  ? -24.240 -39.918 23.767  1.00 56.33  ?  23  TYR C CZ  1 
ATOM   4619 O OH  . TYR C 1 29  ? -25.329 -40.030 22.955  1.00 52.69  ?  23  TYR C OH  1 
ATOM   4620 N N   . ALA C 1 30  ? -18.559 -40.186 28.505  1.00 63.09  ?  24  ALA C N   1 
ATOM   4621 C CA  . ALA C 1 30  ? -17.168 -40.191 28.970  1.00 60.89  ?  24  ALA C CA  1 
ATOM   4622 C C   . ALA C 1 30  ? -16.648 -41.612 29.133  1.00 63.68  ?  24  ALA C C   1 
ATOM   4623 O O   . ALA C 1 30  ? -15.480 -41.906 28.813  1.00 61.21  ?  24  ALA C O   1 
ATOM   4624 C CB  . ALA C 1 30  ? -17.049 -39.421 30.285  1.00 56.58  ?  24  ALA C CB  1 
ATOM   4625 N N   . LEU C 1 31  ? -17.518 -42.510 29.596  1.00 60.98  ?  25  LEU C N   1 
ATOM   4626 C CA  . LEU C 1 31  ? -17.138 -43.902 29.780  1.00 61.72  ?  25  LEU C CA  1 
ATOM   4627 C C   . LEU C 1 31  ? -16.721 -44.529 28.461  1.00 60.71  ?  25  LEU C C   1 
ATOM   4628 O O   . LEU C 1 31  ? -15.688 -45.200 28.378  1.00 62.74  ?  25  LEU C O   1 
ATOM   4629 C CB  . LEU C 1 31  ? -18.304 -44.661 30.407  1.00 64.91  ?  25  LEU C CB  1 
ATOM   4630 C CG  . LEU C 1 31  ? -17.981 -45.989 31.062  1.00 69.70  ?  25  LEU C CG  1 
ATOM   4631 C CD1 . LEU C 1 31  ? -18.715 -46.061 32.392  1.00 67.61  ?  25  LEU C CD1 1 
ATOM   4632 C CD2 . LEU C 1 31  ? -18.387 -47.119 30.121  1.00 74.25  ?  25  LEU C CD2 1 
ATOM   4633 N N   . GLN C 1 32  ? -17.512 -44.309 27.412  1.00 59.96  ?  26  GLN C N   1 
ATOM   4634 C CA  . GLN C 1 32  ? -17.141 -44.818 26.100  1.00 59.31  ?  26  GLN C CA  1 
ATOM   4635 C C   . GLN C 1 32  ? -15.785 -44.277 25.666  1.00 61.69  ?  26  GLN C C   1 
ATOM   4636 O O   . GLN C 1 32  ? -14.931 -45.034 25.180  1.00 62.69  ?  26  GLN C O   1 
ATOM   4637 C CB  . GLN C 1 32  ? -18.228 -44.461 25.084  1.00 59.53  ?  26  GLN C CB  1 
ATOM   4638 C CG  . GLN C 1 32  ? -19.550 -45.131 25.399  1.00 61.09  ?  26  GLN C CG  1 
ATOM   4639 C CD  . GLN C 1 32  ? -20.697 -44.668 24.514  1.00 68.41  ?  26  GLN C CD  1 
ATOM   4640 O OE1 . GLN C 1 32  ? -20.597 -43.668 23.786  1.00 66.94  ?  26  GLN C OE1 1 
ATOM   4641 N NE2 . GLN C 1 32  ? -21.809 -45.384 24.593  1.00 67.96  ?  26  GLN C NE2 1 
ATOM   4642 N N   . ALA C 1 33  ? -15.564 -42.969 25.854  1.00 59.38  ?  27  ALA C N   1 
ATOM   4643 C CA  . ALA C 1 33  ? -14.325 -42.347 25.402  1.00 58.76  ?  27  ALA C CA  1 
ATOM   4644 C C   . ALA C 1 33  ? -13.130 -42.830 26.202  1.00 60.97  ?  27  ALA C C   1 
ATOM   4645 O O   . ALA C 1 33  ? -12.032 -42.955 25.644  1.00 62.01  ?  27  ALA C O   1 
ATOM   4646 C CB  . ALA C 1 33  ? -14.415 -40.827 25.491  1.00 59.25  ?  27  ALA C CB  1 
ATOM   4647 N N   . VAL C 1 34  ? -13.314 -43.109 27.498  1.00 61.45  ?  28  VAL C N   1 
ATOM   4648 C CA  . VAL C 1 34  ? -12.207 -43.635 28.298  1.00 61.77  ?  28  VAL C CA  1 
ATOM   4649 C C   . VAL C 1 34  ? -11.802 -45.010 27.789  1.00 62.79  ?  28  VAL C C   1 
ATOM   4650 O O   . VAL C 1 34  ? -10.624 -45.275 27.516  1.00 64.21  ?  28  VAL C O   1 
ATOM   4651 C CB  . VAL C 1 34  ? -12.582 -43.687 29.787  1.00 62.18  ?  28  VAL C CB  1 
ATOM   4652 C CG1 . VAL C 1 34  ? -11.682 -44.681 30.497  1.00 67.41  ?  28  VAL C CG1 1 
ATOM   4653 C CG2 . VAL C 1 34  ? -12.455 -42.315 30.424  1.00 56.06  ?  28  VAL C CG2 1 
ATOM   4654 N N   . GLU C 1 35  ? -12.779 -45.905 27.656  1.00 60.55  ?  29  GLU C N   1 
ATOM   4655 C CA  . GLU C 1 35  ? -12.487 -47.245 27.187  1.00 60.04  ?  29  GLU C CA  1 
ATOM   4656 C C   . GLU C 1 35  ? -11.756 -47.197 25.864  1.00 62.26  ?  29  GLU C C   1 
ATOM   4657 O O   . GLU C 1 35  ? -10.745 -47.885 25.676  1.00 67.78  ?  29  GLU C O   1 
ATOM   4658 C CB  . GLU C 1 35  ? -13.778 -48.052 27.064  1.00 66.10  ?  29  GLU C CB  1 
ATOM   4659 C CG  . GLU C 1 35  ? -13.604 -49.355 26.281  1.00 74.25  ?  29  GLU C CG  1 
ATOM   4660 C CD  . GLU C 1 35  ? -12.530 -50.284 26.870  1.00 84.23  ?  29  GLU C CD  1 
ATOM   4661 O OE1 . GLU C 1 35  ? -12.792 -50.924 27.917  1.00 87.04  ?  29  GLU C OE1 1 
ATOM   4662 O OE2 . GLU C 1 35  ? -11.421 -50.377 26.284  1.00 87.73  -1 29  GLU C OE2 1 
ATOM   4663 N N   . GLU C 1 36  ? -12.213 -46.340 24.954  1.00 63.93  ?  30  GLU C N   1 
ATOM   4664 C CA  . GLU C 1 36  ? -11.606 -46.278 23.629  1.00 63.62  ?  30  GLU C CA  1 
ATOM   4665 C C   . GLU C 1 36  ? -10.231 -45.610 23.626  1.00 61.69  ?  30  GLU C C   1 
ATOM   4666 O O   . GLU C 1 36  ? -9.423  -45.890 22.732  1.00 65.69  ?  30  GLU C O   1 
ATOM   4667 C CB  . GLU C 1 36  ? -12.538 -45.560 22.668  1.00 60.48  ?  30  GLU C CB  1 
ATOM   4668 C CG  . GLU C 1 36  ? -12.373 -46.013 21.252  1.00 65.62  ?  30  GLU C CG  1 
ATOM   4669 C CD  . GLU C 1 36  ? -12.870 -47.437 21.018  1.00 72.54  ?  30  GLU C CD  1 
ATOM   4670 O OE1 . GLU C 1 36  ? -13.849 -47.873 21.693  1.00 64.29  ?  30  GLU C OE1 1 
ATOM   4671 O OE2 . GLU C 1 36  ? -12.284 -48.111 20.135  1.00 75.11  -1 30  GLU C OE2 1 
ATOM   4672 N N   . ALA C 1 37  ? -9.930  -44.754 24.592  1.00 59.83  ?  31  ALA C N   1 
ATOM   4673 C CA  . ALA C 1 37  ? -8.587  -44.178 24.637  1.00 63.43  ?  31  ALA C CA  1 
ATOM   4674 C C   . ALA C 1 37  ? -7.560  -45.283 24.879  1.00 62.49  ?  31  ALA C C   1 
ATOM   4675 O O   . ALA C 1 37  ? -7.577  -45.922 25.945  1.00 61.18  ?  31  ALA C O   1 
ATOM   4676 C CB  . ALA C 1 37  ? -8.475  -43.101 25.718  1.00 61.96  ?  31  ALA C CB  1 
ATOM   4677 N N   . PRO C 1 38  ? -6.652  -45.529 23.935  1.00 61.48  ?  32  PRO C N   1 
ATOM   4678 C CA  . PRO C 1 38  ? -5.708  -46.648 24.079  1.00 61.82  ?  32  PRO C CA  1 
ATOM   4679 C C   . PRO C 1 38  ? -4.644  -46.431 25.148  1.00 64.98  ?  32  PRO C C   1 
ATOM   4680 O O   . PRO C 1 38  ? -3.919  -47.381 25.474  1.00 68.01  ?  32  PRO C O   1 
ATOM   4681 C CB  . PRO C 1 38  ? -5.075  -46.745 22.682  1.00 58.54  ?  32  PRO C CB  1 
ATOM   4682 C CG  . PRO C 1 38  ? -5.129  -45.347 22.156  1.00 63.12  ?  32  PRO C CG  1 
ATOM   4683 C CD  . PRO C 1 38  ? -6.358  -44.691 22.757  1.00 58.28  ?  32  PRO C CD  1 
ATOM   4684 N N   . ASP C 1 39  ? -4.508  -45.217 25.677  1.00 66.08  ?  33  ASP C N   1 
ATOM   4685 C CA  . ASP C 1 39  ? -3.567  -44.901 26.744  1.00 63.11  ?  33  ASP C CA  1 
ATOM   4686 C C   . ASP C 1 39  ? -4.282  -44.684 28.068  1.00 66.10  ?  33  ASP C C   1 
ATOM   4687 O O   . ASP C 1 39  ? -3.682  -44.140 29.007  1.00 62.12  ?  33  ASP C O   1 
ATOM   4688 C CB  . ASP C 1 39  ? -2.743  -43.668 26.380  1.00 59.45  ?  33  ASP C CB  1 
ATOM   4689 C CG  . ASP C 1 39  ? -3.620  -42.449 25.996  1.00 67.72  ?  33  ASP C CG  1 
ATOM   4690 O OD1 . ASP C 1 39  ? -4.682  -42.641 25.354  1.00 65.91  ?  33  ASP C OD1 1 
ATOM   4691 O OD2 . ASP C 1 39  ? -3.246  -41.292 26.320  1.00 68.50  -1 33  ASP C OD2 1 
ATOM   4692 N N   . MET C 1 40  ? -5.552  -45.104 28.163  1.00 61.64  ?  34  MET C N   1 
ATOM   4693 C CA  . MET C 1 40  ? -6.375  -44.869 29.341  1.00 63.76  ?  34  MET C CA  1 
ATOM   4694 C C   . MET C 1 40  ? -7.149  -46.114 29.735  1.00 64.52  ?  34  MET C C   1 
ATOM   4695 O O   . MET C 1 40  ? -7.684  -46.830 28.878  1.00 70.44  ?  34  MET C O   1 
ATOM   4696 C CB  . MET C 1 40  ? -7.348  -43.726 29.079  1.00 67.13  ?  34  MET C CB  1 
ATOM   4697 C CG  . MET C 1 40  ? -6.650  -42.417 29.049  1.00 67.61  ?  34  MET C CG  1 
ATOM   4698 S SD  . MET C 1 40  ? -7.789  -41.085 28.763  1.00 62.78  ?  34  MET C SD  1 
ATOM   4699 C CE  . MET C 1 40  ? -6.590  -39.924 28.091  1.00 61.49  ?  34  MET C CE  1 
ATOM   4700 N N   . GLU C 1 41  ? -7.242  -46.342 31.042  1.00 64.98  ?  35  GLU C N   1 
ATOM   4701 C CA  . GLU C 1 41  ? -8.101  -47.392 31.572  1.00 68.65  ?  35  GLU C CA  1 
ATOM   4702 C C   . GLU C 1 41  ? -9.037  -46.819 32.631  1.00 65.44  ?  35  GLU C C   1 
ATOM   4703 O O   . GLU C 1 41  ? -8.686  -45.896 33.368  1.00 65.31  ?  35  GLU C O   1 
ATOM   4704 C CB  . GLU C 1 41  ? -7.282  -48.563 32.146  1.00 69.11  ?  35  GLU C CB  1 
ATOM   4705 C CG  . GLU C 1 41  ? -6.844  -48.382 33.589  1.00 73.23  ?  35  GLU C CG  1 
ATOM   4706 C CD  . GLU C 1 41  ? -6.132  -49.608 34.132  1.00 79.14  ?  35  GLU C CD  1 
ATOM   4707 O OE1 . GLU C 1 41  ? -5.983  -50.582 33.356  1.00 76.20  ?  35  GLU C OE1 1 
ATOM   4708 O OE2 . GLU C 1 41  ? -5.715  -49.591 35.322  1.00 77.78  -1 35  GLU C OE2 1 
ATOM   4709 N N   . LEU C 1 42  ? -10.251 -47.357 32.683  1.00 70.91  ?  36  LEU C N   1 
ATOM   4710 C CA  . LEU C 1 42  ? -11.222 -46.866 33.652  1.00 71.14  ?  36  LEU C CA  1 
ATOM   4711 C C   . LEU C 1 42  ? -10.846 -47.356 35.038  1.00 71.58  ?  36  LEU C C   1 
ATOM   4712 O O   . LEU C 1 42  ? -10.615 -48.552 35.240  1.00 72.33  ?  36  LEU C O   1 
ATOM   4713 C CB  . LEU C 1 42  ? -12.625 -47.355 33.308  1.00 70.24  ?  36  LEU C CB  1 
ATOM   4714 C CG  . LEU C 1 42  ? -13.765 -46.665 34.055  1.00 68.18  ?  36  LEU C CG  1 
ATOM   4715 C CD1 . LEU C 1 42  ? -13.548 -45.178 34.112  1.00 66.24  ?  36  LEU C CD1 1 
ATOM   4716 C CD2 . LEU C 1 42  ? -15.107 -46.981 33.410  1.00 75.53  ?  36  LEU C CD2 1 
ATOM   4717 N N   . ALA C 1 43  ? -10.773 -46.445 35.995  1.00 68.41  ?  37  ALA C N   1 
ATOM   4718 C CA  . ALA C 1 43  ? -10.576 -46.891 37.366  1.00 70.15  ?  37  ALA C CA  1 
ATOM   4719 C C   . ALA C 1 43  ? -11.899 -47.195 38.058  1.00 75.22  ?  37  ALA C C   1 
ATOM   4720 O O   . ALA C 1 43  ? -11.971 -48.100 38.903  1.00 69.17  ?  37  ALA C O   1 
ATOM   4721 C CB  . ALA C 1 43  ? -9.794  -45.840 38.155  1.00 67.26  ?  37  ALA C CB  1 
ATOM   4722 N N   . GLY C 1 44  ? -12.945 -46.475 37.704  1.00 72.32  ?  38  GLY C N   1 
ATOM   4723 C CA  . GLY C 1 44  ? -14.229 -46.664 38.342  1.00 71.14  ?  38  GLY C CA  1 
ATOM   4724 C C   . GLY C 1 44  ? -15.035 -45.391 38.286  1.00 72.07  ?  38  GLY C C   1 
ATOM   4725 O O   . GLY C 1 44  ? -14.538 -44.325 37.940  1.00 77.65  ?  38  GLY C O   1 
ATOM   4726 N N   . VAL C 1 45  ? -16.305 -45.525 38.642  1.00 70.78  ?  39  VAL C N   1 
ATOM   4727 C CA  . VAL C 1 45  ? -17.273 -44.440 38.584  1.00 71.81  ?  39  VAL C CA  1 
ATOM   4728 C C   . VAL C 1 45  ? -17.682 -44.072 40.004  1.00 73.79  ?  39  VAL C C   1 
ATOM   4729 O O   . VAL C 1 45  ? -17.936 -44.953 40.835  1.00 77.02  ?  39  VAL C O   1 
ATOM   4730 C CB  . VAL C 1 45  ? -18.483 -44.862 37.732  1.00 73.39  ?  39  VAL C CB  1 
ATOM   4731 C CG1 . VAL C 1 45  ? -19.593 -43.814 37.786  1.00 70.71  ?  39  VAL C CG1 1 
ATOM   4732 C CG2 . VAL C 1 45  ? -18.020 -45.145 36.303  1.00 70.35  ?  39  VAL C CG2 1 
ATOM   4733 N N   . VAL C 1 46  ? -17.727 -42.773 40.283  1.00 69.66  ?  40  VAL C N   1 
ATOM   4734 C CA  . VAL C 1 46  ? -18.060 -42.240 41.597  1.00 73.12  ?  40  VAL C CA  1 
ATOM   4735 C C   . VAL C 1 46  ? -19.408 -41.546 41.493  1.00 75.80  ?  40  VAL C C   1 
ATOM   4736 O O   . VAL C 1 46  ? -19.555 -40.580 40.734  1.00 73.74  ?  40  VAL C O   1 
ATOM   4737 C CB  . VAL C 1 46  ? -16.997 -41.254 42.097  1.00 74.53  ?  40  VAL C CB  1 
ATOM   4738 C CG1 . VAL C 1 46  ? -17.499 -40.526 43.355  1.00 75.22  ?  40  VAL C CG1 1 
ATOM   4739 C CG2 . VAL C 1 46  ? -15.690 -41.963 42.337  1.00 73.37  ?  40  VAL C CG2 1 
ATOM   4740 N N   . ARG C 1 47  ? -20.382 -42.023 42.269  1.00 77.28  ?  41  ARG C N   1 
ATOM   4741 C CA  . ARG C 1 47  ? -21.730 -41.477 42.277  1.00 79.56  ?  41  ARG C CA  1 
ATOM   4742 C C   . ARG C 1 47  ? -22.079 -41.030 43.691  1.00 81.13  ?  41  ARG C C   1 
ATOM   4743 O O   . ARG C 1 47  ? -21.445 -41.446 44.669  1.00 79.76  ?  41  ARG C O   1 
ATOM   4744 C CB  . ARG C 1 47  ? -22.751 -42.518 41.790  1.00 78.69  ?  41  ARG C CB  1 
ATOM   4745 C CG  . ARG C 1 47  ? -22.203 -43.489 40.736  1.00 74.92  ?  41  ARG C CG  1 
ATOM   4746 C CD  . ARG C 1 47  ? -23.312 -44.139 39.908  1.00 72.36  ?  41  ARG C CD  1 
ATOM   4747 N NE  . ARG C 1 47  ? -24.393 -43.190 39.672  1.00 79.36  ?  41  ARG C NE  1 
ATOM   4748 C CZ  . ARG C 1 47  ? -25.509 -43.450 39.006  1.00 79.70  ?  41  ARG C CZ  1 
ATOM   4749 N NH1 . ARG C 1 47  ? -25.732 -44.632 38.456  1.00 78.22  ?  41  ARG C NH1 1 
ATOM   4750 N NH2 . ARG C 1 47  ? -26.425 -42.493 38.885  1.00 84.28  ?  41  ARG C NH2 1 
ATOM   4751 N N   . ARG C 1 48  ? -23.085 -40.162 43.797  1.00 83.26  ?  42  ARG C N   1 
ATOM   4752 C CA  . ARG C 1 48  ? -23.649 -39.867 45.107  1.00 83.91  ?  42  ARG C CA  1 
ATOM   4753 C C   . ARG C 1 48  ? -24.130 -41.165 45.764  1.00 89.92  ?  42  ARG C C   1 
ATOM   4754 O O   . ARG C 1 48  ? -24.365 -42.182 45.096  1.00 88.27  ?  42  ARG C O   1 
ATOM   4755 C CB  . ARG C 1 48  ? -24.800 -38.871 44.986  1.00 77.45  ?  42  ARG C CB  1 
ATOM   4756 C CG  . ARG C 1 48  ? -24.435 -37.544 44.331  1.00 78.31  ?  42  ARG C CG  1 
ATOM   4757 C CD  . ARG C 1 48  ? -25.681 -36.822 43.809  1.00 73.17  ?  42  ARG C CD  1 
ATOM   4758 N NE  . ARG C 1 48  ? -26.251 -37.553 42.681  1.00 77.91  ?  42  ARG C NE  1 
ATOM   4759 C CZ  . ARG C 1 48  ? -27.385 -37.242 42.065  1.00 76.81  ?  42  ARG C CZ  1 
ATOM   4760 N NH1 . ARG C 1 48  ? -28.131 -36.225 42.457  1.00 72.76  ?  42  ARG C NH1 1 
ATOM   4761 N NH2 . ARG C 1 48  ? -27.777 -37.968 41.020  1.00 73.79  ?  42  ARG C NH2 1 
ATOM   4762 N N   . GLN C 1 49  ? -24.253 -41.140 47.097  1.00 92.49  ?  43  GLN C N   1 
ATOM   4763 C CA  . GLN C 1 49  ? -24.703 -42.340 47.801  1.00 90.94  ?  43  GLN C CA  1 
ATOM   4764 C C   . GLN C 1 49  ? -26.120 -42.731 47.396  1.00 92.76  ?  43  GLN C C   1 
ATOM   4765 O O   . GLN C 1 49  ? -26.442 -43.924 47.327  1.00 92.17  ?  43  GLN C O   1 
ATOM   4766 C CB  . GLN C 1 49  ? -24.626 -42.137 49.314  1.00 87.81  ?  43  GLN C CB  1 
ATOM   4767 C CG  . GLN C 1 49  ? -24.535 -43.442 50.079  1.00 88.29  ?  43  GLN C CG  1 
ATOM   4768 C CD  . GLN C 1 49  ? -23.137 -44.043 50.026  1.00 93.82  ?  43  GLN C CD  1 
ATOM   4769 O OE1 . GLN C 1 49  ? -22.948 -45.160 49.532  1.00 94.76  ?  43  GLN C OE1 1 
ATOM   4770 N NE2 . GLN C 1 49  ? -22.148 -43.309 50.546  1.00 85.17  ?  43  GLN C NE2 1 
ATOM   4771 N N   . SER C 1 50  ? -26.970 -41.742 47.104  1.00 85.77  ?  44  SER C N   1 
ATOM   4772 C CA  . SER C 1 50  ? -28.344 -42.033 46.723  1.00 88.29  ?  44  SER C CA  1 
ATOM   4773 C C   . SER C 1 50  ? -28.408 -42.854 45.441  1.00 90.95  ?  44  SER C C   1 
ATOM   4774 O O   . SER C 1 50  ? -29.325 -43.667 45.266  1.00 95.52  ?  44  SER C O   1 
ATOM   4775 C CB  . SER C 1 50  ? -29.127 -40.726 46.578  1.00 80.62  ?  44  SER C CB  1 
ATOM   4776 O OG  . SER C 1 50  ? -29.093 -40.254 45.242  1.00 79.99  ?  44  SER C OG  1 
ATOM   4777 N N   . SER C 1 51  ? -27.447 -42.668 44.540  1.00 88.38  ?  45  SER C N   1 
ATOM   4778 C CA  . SER C 1 51  ? -27.473 -43.413 43.288  1.00 86.91  ?  45  SER C CA  1 
ATOM   4779 C C   . SER C 1 51  ? -26.864 -44.798 43.436  1.00 90.90  ?  45  SER C C   1 
ATOM   4780 O O   . SER C 1 51  ? -27.187 -45.697 42.654  1.00 95.21  ?  45  SER C O   1 
ATOM   4781 C CB  . SER C 1 51  ? -26.743 -42.627 42.194  1.00 85.66  ?  45  SER C CB  1 
ATOM   4782 O OG  . SER C 1 51  ? -27.044 -41.241 42.270  1.00 85.52  ?  45  SER C OG  1 
ATOM   4783 N N   . LEU C 1 52  ? -25.976 -44.993 44.413  1.00 88.93  ?  46  LEU C N   1 
ATOM   4784 C CA  . LEU C 1 52  ? -25.467 -46.334 44.664  1.00 90.03  ?  46  LEU C CA  1 
ATOM   4785 C C   . LEU C 1 52  ? -26.586 -47.283 45.082  1.00 97.47  ?  46  LEU C C   1 
ATOM   4786 O O   . LEU C 1 52  ? -26.492 -48.494 44.844  1.00 100.12 ?  46  LEU C O   1 
ATOM   4787 C CB  . LEU C 1 52  ? -24.358 -46.293 45.723  1.00 89.25  ?  46  LEU C CB  1 
ATOM   4788 C CG  . LEU C 1 52  ? -23.103 -45.441 45.467  1.00 91.68  ?  46  LEU C CG  1 
ATOM   4789 C CD1 . LEU C 1 52  ? -21.987 -45.802 46.445  1.00 88.05  ?  46  LEU C CD1 1 
ATOM   4790 C CD2 . LEU C 1 52  ? -22.591 -45.581 44.031  1.00 86.06  ?  46  LEU C CD2 1 
ATOM   4791 N N   . GLU C 1 53  ? -27.655 -46.751 45.694  1.00 97.02  ?  47  GLU C N   1 
ATOM   4792 C CA  . GLU C 1 53  ? -28.798 -47.580 46.071  1.00 97.35  ?  47  GLU C CA  1 
ATOM   4793 C C   . GLU C 1 53  ? -29.618 -47.990 44.858  1.00 95.81  ?  47  GLU C C   1 
ATOM   4794 O O   . GLU C 1 53  ? -30.247 -49.053 44.868  1.00 97.22  ?  47  GLU C O   1 
ATOM   4795 C CB  . GLU C 1 53  ? -29.686 -46.842 47.077  1.00 96.26  ?  47  GLU C CB  1 
ATOM   4796 C CG  . GLU C 1 53  ? -28.991 -46.484 48.388  1.00 95.32  ?  47  GLU C CG  1 
ATOM   4797 C CD  . GLU C 1 53  ? -29.603 -45.267 49.062  1.00 100.72 ?  47  GLU C CD  1 
ATOM   4798 O OE1 . GLU C 1 53  ? -30.701 -44.844 48.632  1.00 102.05 ?  47  GLU C OE1 1 
ATOM   4799 O OE2 . GLU C 1 53  ? -28.983 -44.722 50.008  1.00 100.64 -1 47  GLU C OE2 1 
ATOM   4800 N N   . LYS C 1 54  ? -29.613 -47.167 43.811  1.00 94.58  ?  48  LYS C N   1 
ATOM   4801 C CA  . LYS C 1 54  ? -30.415 -47.432 42.631  1.00 94.70  ?  48  LYS C CA  1 
ATOM   4802 C C   . LYS C 1 54  ? -29.956 -48.722 41.955  1.00 92.60  ?  48  LYS C C   1 
ATOM   4803 O O   . LYS C 1 54  ? -28.892 -49.261 42.273  1.00 89.81  ?  48  LYS C O   1 
ATOM   4804 C CB  . LYS C 1 54  ? -30.333 -46.247 41.671  1.00 96.06  ?  48  LYS C CB  1 
ATOM   4805 C CG  . LYS C 1 54  ? -31.332 -45.125 41.974  1.00 96.72  ?  48  LYS C CG  1 
ATOM   4806 C CD  . LYS C 1 54  ? -32.789 -45.572 41.761  1.00 98.38  ?  48  LYS C CD  1 
ATOM   4807 C CE  . LYS C 1 54  ? -33.744 -44.387 41.842  1.00 98.93  ?  48  LYS C CE  1 
ATOM   4808 N NZ  . LYS C 1 54  ? -34.968 -44.580 41.027  1.00 96.61  ?  48  LYS C NZ  1 
ATOM   4809 N N   . PRO C 1 55  ? -30.762 -49.262 41.046  1.00 94.39  ?  49  PRO C N   1 
ATOM   4810 C CA  . PRO C 1 55  ? -30.327 -50.450 40.313  1.00 93.97  ?  49  PRO C CA  1 
ATOM   4811 C C   . PRO C 1 55  ? -29.157 -50.113 39.409  1.00 93.54  ?  49  PRO C C   1 
ATOM   4812 O O   . PRO C 1 55  ? -29.121 -49.060 38.771  1.00 97.83  ?  49  PRO C O   1 
ATOM   4813 C CB  . PRO C 1 55  ? -31.568 -50.853 39.506  1.00 97.54  ?  49  PRO C CB  1 
ATOM   4814 C CG  . PRO C 1 55  ? -32.714 -50.170 40.184  1.00 100.89 ?  49  PRO C CG  1 
ATOM   4815 C CD  . PRO C 1 55  ? -32.144 -48.888 40.697  1.00 99.60  ?  49  PRO C CD  1 
ATOM   4816 N N   . LEU C 1 56  ? -28.192 -51.036 39.338  1.00 90.64  ?  50  LEU C N   1 
ATOM   4817 C CA  . LEU C 1 56  ? -26.958 -50.800 38.545  1.00 91.45  ?  50  LEU C CA  1 
ATOM   4818 C C   . LEU C 1 56  ? -27.238 -50.970 37.051  1.00 91.64  ?  50  LEU C C   1 
ATOM   4819 O O   . LEU C 1 56  ? -27.845 -51.984 36.671  1.00 97.15  ?  50  LEU C O   1 
ATOM   4820 C CB  . LEU C 1 56  ? -25.868 -51.767 38.999  1.00 85.23  ?  50  LEU C CB  1 
ATOM   4821 C CG  . LEU C 1 56  ? -24.499 -51.601 38.335  1.00 88.28  ?  50  LEU C CG  1 
ATOM   4822 C CD1 . LEU C 1 56  ? -23.695 -50.553 39.076  1.00 85.96  ?  50  LEU C CD1 1 
ATOM   4823 C CD2 . LEU C 1 56  ? -23.755 -52.920 38.305  1.00 88.91  ?  50  LEU C CD2 1 
ATOM   4824 N N   . PRO C 1 57  ? -26.807 -50.042 36.158  1.00 90.07  ?  51  PRO C N   1 
ATOM   4825 C CA  . PRO C 1 57  ? -27.004 -50.229 34.732  1.00 88.48  ?  51  PRO C CA  1 
ATOM   4826 C C   . PRO C 1 57  ? -26.160 -51.354 34.185  1.00 89.68  ?  51  PRO C C   1 
ATOM   4827 O O   . PRO C 1 57  ? -25.203 -51.837 34.790  1.00 90.86  ?  51  PRO C O   1 
ATOM   4828 C CB  . PRO C 1 57  ? -26.604 -48.882 34.129  1.00 87.92  ?  51  PRO C CB  1 
ATOM   4829 C CG  . PRO C 1 57  ? -26.686 -47.915 35.279  1.00 86.35  ?  51  PRO C CG  1 
ATOM   4830 C CD  . PRO C 1 57  ? -26.157 -48.745 36.423  1.00 88.36  ?  51  PRO C CD  1 
ATOM   4831 N N   . GLY C 1 62  ? -19.331 -55.065 36.188  1.00 83.48  ?  56  GLY C N   1 
ATOM   4832 C CA  . GLY C 1 62  ? -17.890 -55.217 36.293  1.00 83.62  ?  56  GLY C CA  1 
ATOM   4833 C C   . GLY C 1 62  ? -17.123 -53.923 36.468  1.00 85.78  ?  56  GLY C C   1 
ATOM   4834 O O   . GLY C 1 62  ? -15.887 -53.941 36.459  1.00 83.62  ?  56  GLY C O   1 
ATOM   4835 N N   . VAL C 1 63  ? -17.811 -52.796 36.618  1.00 79.79  ?  57  VAL C N   1 
ATOM   4836 C CA  . VAL C 1 63  ? -17.168 -51.506 36.802  1.00 78.10  ?  57  VAL C CA  1 
ATOM   4837 C C   . VAL C 1 63  ? -17.335 -51.114 38.259  1.00 79.80  ?  57  VAL C C   1 
ATOM   4838 O O   . VAL C 1 63  ? -18.468 -51.022 38.752  1.00 82.40  ?  57  VAL C O   1 
ATOM   4839 C CB  . VAL C 1 63  ? -17.763 -50.439 35.871  1.00 77.81  ?  57  VAL C CB  1 
ATOM   4840 C CG1 . VAL C 1 63  ? -17.161 -49.072 36.186  1.00 73.72  ?  57  VAL C CG1 1 
ATOM   4841 C CG2 . VAL C 1 63  ? -17.549 -50.828 34.420  1.00 71.20  ?  57  VAL C CG2 1 
ATOM   4842 N N   . SER C 1 64  ? -16.212 -50.877 38.946  1.00 76.79  ?  58  SER C N   1 
ATOM   4843 C CA  . SER C 1 64  ? -16.261 -50.454 40.340  1.00 73.31  ?  58  SER C CA  1 
ATOM   4844 C C   . SER C 1 64  ? -17.000 -49.131 40.489  1.00 77.27  ?  58  SER C C   1 
ATOM   4845 O O   . SER C 1 64  ? -16.462 -48.072 40.154  1.00 81.25  ?  58  SER C O   1 
ATOM   4846 C CB  . SER C 1 64  ? -14.854 -50.341 40.908  1.00 69.29  ?  58  SER C CB  1 
ATOM   4847 O OG  . SER C 1 64  ? -14.057 -51.408 40.437  1.00 83.50  ?  58  SER C OG  1 
ATOM   4848 N N   . VAL C 1 65  ? -18.232 -49.178 40.982  1.00 72.74  ?  59  VAL C N   1 
ATOM   4849 C CA  . VAL C 1 65  ? -19.056 -47.991 41.173  1.00 74.29  ?  59  VAL C CA  1 
ATOM   4850 C C   . VAL C 1 65  ? -19.093 -47.711 42.665  1.00 78.29  ?  59  VAL C C   1 
ATOM   4851 O O   . VAL C 1 65  ? -19.657 -48.497 43.435  1.00 81.12  ?  59  VAL C O   1 
ATOM   4852 C CB  . VAL C 1 65  ? -20.461 -48.189 40.601  1.00 72.67  ?  59  VAL C CB  1 
ATOM   4853 C CG1 . VAL C 1 65  ? -21.293 -46.951 40.807  1.00 70.67  ?  59  VAL C CG1 1 
ATOM   4854 C CG2 . VAL C 1 65  ? -20.358 -48.557 39.131  1.00 74.01  ?  59  VAL C CG2 1 
ATOM   4855 N N   . VAL C 1 66  ? -18.471 -46.609 43.087  1.00 79.28  ?  60  VAL C N   1 
ATOM   4856 C CA  . VAL C 1 66  ? -18.192 -46.349 44.494  1.00 76.03  ?  60  VAL C CA  1 
ATOM   4857 C C   . VAL C 1 66  ? -18.646 -44.934 44.840  1.00 75.93  ?  60  VAL C C   1 
ATOM   4858 O O   . VAL C 1 66  ? -19.186 -44.215 44.004  1.00 78.83  ?  60  VAL C O   1 
ATOM   4859 C CB  . VAL C 1 66  ? -16.703 -46.555 44.840  1.00 73.85  ?  60  VAL C CB  1 
ATOM   4860 C CG1 . VAL C 1 66  ? -16.179 -47.803 44.181  1.00 73.35  ?  60  VAL C CG1 1 
ATOM   4861 C CG2 . VAL C 1 66  ? -15.883 -45.372 44.388  1.00 80.34  ?  60  VAL C CG2 1 
ATOM   4862 N N   . SER C 1 67  ? -18.430 -44.541 46.095  1.00 78.87  ?  61  SER C N   1 
ATOM   4863 C CA  . SER C 1 67  ? -18.881 -43.245 46.589  1.00 82.13  ?  61  SER C CA  1 
ATOM   4864 C C   . SER C 1 67  ? -17.747 -42.252 46.816  1.00 82.08  ?  61  SER C C   1 
ATOM   4865 O O   . SER C 1 67  ? -18.022 -41.098 47.154  1.00 83.49  ?  61  SER C O   1 
ATOM   4866 C CB  . SER C 1 67  ? -19.661 -43.416 47.898  1.00 80.07  ?  61  SER C CB  1 
ATOM   4867 O OG  . SER C 1 67  ? -18.830 -43.965 48.901  1.00 75.96  ?  61  SER C OG  1 
ATOM   4868 N N   . ASP C 1 68  ? -16.498 -42.705 46.690  1.00 78.61  ?  62  ASP C N   1 
ATOM   4869 C CA  . ASP C 1 68  ? -15.324 -41.804 46.859  1.00 83.92  ?  62  ASP C CA  1 
ATOM   4870 C C   . ASP C 1 68  ? -14.125 -42.348 46.083  1.00 83.71  ?  62  ASP C C   1 
ATOM   4871 O O   . ASP C 1 68  ? -13.954 -43.573 46.028  1.00 80.76  ?  62  ASP C O   1 
ATOM   4872 C CB  . ASP C 1 68  ? -14.958 -41.575 48.315  1.00 83.72  ?  62  ASP C CB  1 
ATOM   4873 C CG  . ASP C 1 68  ? -13.994 -40.423 48.557  1.00 88.55  ?  62  ASP C CG  1 
ATOM   4874 O OD1 . ASP C 1 68  ? -12.783 -40.617 48.332  1.00 86.28  ?  62  ASP C OD1 1 
ATOM   4875 O OD2 . ASP C 1 68  ? -14.465 -39.339 48.955  1.00 90.35  -1 62  ASP C OD2 1 
ATOM   4876 N N   . VAL C 1 69  ? -13.290 -41.455 45.563  1.00 81.74  ?  63  VAL C N   1 
ATOM   4877 C CA  . VAL C 1 69  ? -12.181 -41.899 44.718  1.00 84.22  ?  63  VAL C CA  1 
ATOM   4878 C C   . VAL C 1 69  ? -11.269 -42.856 45.468  1.00 82.34  ?  63  VAL C C   1 
ATOM   4879 O O   . VAL C 1 69  ? -10.653 -43.743 44.859  1.00 80.86  ?  63  VAL C O   1 
ATOM   4880 C CB  . VAL C 1 69  ? -11.386 -40.694 44.163  1.00 80.81  ?  63  VAL C CB  1 
ATOM   4881 C CG1 . VAL C 1 69  ? -12.186 -39.984 43.085  1.00 74.82  ?  63  VAL C CG1 1 
ATOM   4882 C CG2 . VAL C 1 69  ? -10.980 -39.733 45.276  1.00 80.09  ?  63  VAL C CG2 1 
ATOM   4883 N N   . SER C 1 70  ? -11.167 -42.704 46.792  1.00 84.08  ?  64  SER C N   1 
ATOM   4884 C CA  . SER C 1 70  ? -10.306 -43.578 47.585  1.00 81.38  ?  64  SER C CA  1 
ATOM   4885 C C   . SER C 1 70  ? -10.603 -45.052 47.341  1.00 79.46  ?  64  SER C C   1 
ATOM   4886 O O   . SER C 1 70  ? -9.691  -45.884 47.365  1.00 80.48  ?  64  SER C O   1 
ATOM   4887 C CB  . SER C 1 70  ? -10.470 -43.242 49.062  1.00 79.92  ?  64  SER C CB  1 
ATOM   4888 O OG  . SER C 1 70  ? -11.772 -42.732 49.289  1.00 84.74  ?  64  SER C OG  1 
ATOM   4889 N N   . ALA C 1 71  ? -11.862 -45.396 47.074  1.00 78.74  ?  65  ALA C N   1 
ATOM   4890 C CA  . ALA C 1 71  ? -12.203 -46.791 46.838  1.00 76.67  ?  65  ALA C CA  1 
ATOM   4891 C C   . ALA C 1 71  ? -11.660 -47.331 45.524  1.00 77.56  ?  65  ALA C C   1 
ATOM   4892 O O   . ALA C 1 71  ? -11.640 -48.550 45.342  1.00 81.95  ?  65  ALA C O   1 
ATOM   4893 C CB  . ALA C 1 71  ? -13.718 -46.972 46.869  1.00 75.62  ?  65  ALA C CB  1 
ATOM   4894 N N   . LEU C 1 72  ? -11.216 -46.477 44.609  1.00 76.16  ?  66  LEU C N   1 
ATOM   4895 C CA  . LEU C 1 72  ? -10.875 -46.925 43.268  1.00 73.96  ?  66  LEU C CA  1 
ATOM   4896 C C   . LEU C 1 72  ? -9.396  -47.189 43.079  1.00 73.56  ?  66  LEU C C   1 
ATOM   4897 O O   . LEU C 1 72  ? -8.973  -47.463 41.953  1.00 75.44  ?  66  LEU C O   1 
ATOM   4898 C CB  . LEU C 1 72  ? -11.343 -45.914 42.227  1.00 76.76  ?  66  LEU C CB  1 
ATOM   4899 C CG  . LEU C 1 72  ? -12.769 -45.397 42.362  1.00 78.47  ?  66  LEU C CG  1 
ATOM   4900 C CD1 . LEU C 1 72  ? -12.880 -44.029 41.718  1.00 77.34  ?  66  LEU C CD1 1 
ATOM   4901 C CD2 . LEU C 1 72  ? -13.746 -46.400 41.751  1.00 79.81  ?  66  LEU C CD2 1 
ATOM   4902 N N   . GLY C 1 73  ? -8.601  -47.123 44.141  1.00 79.46  ?  67  GLY C N   1 
ATOM   4903 C CA  . GLY C 1 73  ? -7.183  -47.391 43.987  1.00 79.94  ?  67  GLY C CA  1 
ATOM   4904 C C   . GLY C 1 73  ? -6.480  -46.198 43.366  1.00 73.26  ?  67  GLY C C   1 
ATOM   4905 O O   . GLY C 1 73  ? -6.868  -45.052 43.586  1.00 79.78  ?  67  GLY C O   1 
ATOM   4906 N N   . GLN C 1 74  ? -5.446  -46.479 42.565  1.00 76.68  ?  68  GLN C N   1 
ATOM   4907 C CA  . GLN C 1 74  ? -4.691  -45.418 41.899  1.00 77.23  ?  68  GLN C CA  1 
ATOM   4908 C C   . GLN C 1 74  ? -5.560  -44.683 40.881  1.00 77.81  ?  68  GLN C C   1 
ATOM   4909 O O   . GLN C 1 74  ? -6.168  -45.302 39.992  1.00 75.74  ?  68  GLN C O   1 
ATOM   4910 C CB  . GLN C 1 74  ? -3.451  -45.983 41.204  1.00 73.19  ?  68  GLN C CB  1 
ATOM   4911 C CG  . GLN C 1 74  ? -2.591  -44.930 40.489  1.00 75.66  ?  68  GLN C CG  1 
ATOM   4912 C CD  . GLN C 1 74  ? -1.866  -44.003 41.458  1.00 88.83  ?  68  GLN C CD  1 
ATOM   4913 O OE1 . GLN C 1 74  ? -1.697  -44.329 42.637  1.00 95.93  ?  68  GLN C OE1 1 
ATOM   4914 N NE2 . GLN C 1 74  ? -1.447  -42.834 40.970  1.00 85.58  ?  68  GLN C NE2 1 
ATOM   4915 N N   . VAL C 1 75  ? -5.614  -43.357 41.016  1.00 69.08  ?  69  VAL C N   1 
ATOM   4916 C CA  . VAL C 1 75  ? -6.398  -42.518 40.121  1.00 71.36  ?  69  VAL C CA  1 
ATOM   4917 C C   . VAL C 1 75  ? -5.620  -41.255 39.789  1.00 71.64  ?  69  VAL C C   1 
ATOM   4918 O O   . VAL C 1 75  ? -5.584  -40.317 40.591  1.00 71.18  ?  69  VAL C O   1 
ATOM   4919 C CB  . VAL C 1 75  ? -7.760  -42.145 40.733  1.00 68.31  ?  69  VAL C CB  1 
ATOM   4920 C CG1 . VAL C 1 75  ? -8.531  -41.253 39.764  1.00 69.53  ?  69  VAL C CG1 1 
ATOM   4921 C CG2 . VAL C 1 75  ? -8.567  -43.381 41.071  1.00 69.90  ?  69  VAL C CG2 1 
ATOM   4922 N N   . ASP C 1 76  ? -5.025  -41.208 38.593  1.00 69.22  ?  70  ASP C N   1 
ATOM   4923 C CA  . ASP C 1 76  ? -4.290  -40.018 38.164  1.00 65.76  ?  70  ASP C CA  1 
ATOM   4924 C C   . ASP C 1 76  ? -5.229  -38.851 37.830  1.00 70.91  ?  70  ASP C C   1 
ATOM   4925 O O   . ASP C 1 76  ? -4.984  -37.706 38.232  1.00 72.50  ?  70  ASP C O   1 
ATOM   4926 C CB  . ASP C 1 76  ? -3.423  -40.368 36.961  1.00 70.36  ?  70  ASP C CB  1 
ATOM   4927 C CG  . ASP C 1 76  ? -2.721  -41.711 37.117  1.00 74.76  ?  70  ASP C CG  1 
ATOM   4928 O OD1 . ASP C 1 76  ? -1.850  -41.828 38.011  1.00 81.04  ?  70  ASP C OD1 1 
ATOM   4929 O OD2 . ASP C 1 76  ? -3.035  -42.648 36.349  1.00 73.55  -1 70  ASP C OD2 1 
ATOM   4930 N N   . VAL C 1 77  ? -6.303  -39.105 37.086  1.00 69.30  ?  71  VAL C N   1 
ATOM   4931 C CA  . VAL C 1 77  ? -7.164  -38.034 36.595  1.00 67.99  ?  71  VAL C CA  1 
ATOM   4932 C C   . VAL C 1 77  ? -8.612  -38.395 36.878  1.00 65.82  ?  71  VAL C C   1 
ATOM   4933 O O   . VAL C 1 77  ? -9.056  -39.501 36.550  1.00 71.15  ?  71  VAL C O   1 
ATOM   4934 C CB  . VAL C 1 77  ? -6.968  -37.773 35.086  1.00 68.96  ?  71  VAL C CB  1 
ATOM   4935 C CG1 . VAL C 1 77  ? -7.749  -36.555 34.664  1.00 67.35  ?  71  VAL C CG1 1 
ATOM   4936 C CG2 . VAL C 1 77  ? -5.472  -37.625 34.715  1.00 68.62  ?  71  VAL C CG2 1 
ATOM   4937 N N   . ALA C 1 78  ? -9.348  -37.460 37.466  1.00 65.67  ?  72  ALA C N   1 
ATOM   4938 C CA  . ALA C 1 78  ? -10.795 -37.563 37.621  1.00 65.58  ?  72  ALA C CA  1 
ATOM   4939 C C   . ALA C 1 78  ? -11.479 -36.633 36.625  1.00 67.78  ?  72  ALA C C   1 
ATOM   4940 O O   . ALA C 1 78  ? -11.242 -35.419 36.640  1.00 64.97  ?  72  ALA C O   1 
ATOM   4941 C CB  . ALA C 1 78  ? -11.217 -37.203 39.040  1.00 69.82  ?  72  ALA C CB  1 
ATOM   4942 N N   . VAL C 1 79  ? -12.332 -37.206 35.781  1.00 64.50  ?  73  VAL C N   1 
ATOM   4943 C CA  . VAL C 1 79  ? -13.065 -36.478 34.748  1.00 63.96  ?  73  VAL C CA  1 
ATOM   4944 C C   . VAL C 1 79  ? -14.423 -36.083 35.331  1.00 69.43  ?  73  VAL C C   1 
ATOM   4945 O O   . VAL C 1 79  ? -15.290 -36.933 35.553  1.00 67.26  ?  73  VAL C O   1 
ATOM   4946 C CB  . VAL C 1 79  ? -13.219 -37.340 33.485  1.00 64.00  ?  73  VAL C CB  1 
ATOM   4947 C CG1 . VAL C 1 79  ? -14.184 -36.727 32.494  1.00 59.05  ?  73  VAL C CG1 1 
ATOM   4948 C CG2 . VAL C 1 79  ? -11.853 -37.562 32.837  1.00 67.48  ?  73  VAL C CG2 1 
ATOM   4949 N N   . LEU C 1 80  ? -14.619 -34.796 35.588  1.00 64.18  ?  74  LEU C N   1 
ATOM   4950 C CA  . LEU C 1 80  ? -15.783 -34.356 36.345  1.00 63.80  ?  74  LEU C CA  1 
ATOM   4951 C C   . LEU C 1 80  ? -16.966 -34.172 35.403  1.00 63.21  ?  74  LEU C C   1 
ATOM   4952 O O   . LEU C 1 80  ? -16.943 -33.298 34.534  1.00 60.01  ?  74  LEU C O   1 
ATOM   4953 C CB  . LEU C 1 80  ? -15.485 -33.058 37.085  1.00 59.71  ?  74  LEU C CB  1 
ATOM   4954 C CG  . LEU C 1 80  ? -14.728 -33.128 38.406  1.00 61.28  ?  74  LEU C CG  1 
ATOM   4955 C CD1 . LEU C 1 80  ? -13.558 -34.083 38.337  1.00 67.01  ?  74  LEU C CD1 1 
ATOM   4956 C CD2 . LEU C 1 80  ? -14.229 -31.762 38.724  1.00 63.35  ?  74  LEU C CD2 1 
ATOM   4957 N N   . CYS C 1 81  ? -18.002 -34.983 35.573  1.00 67.23  ?  75  CYS C N   1 
ATOM   4958 C CA  . CYS C 1 81  ? -19.208 -34.847 34.760  1.00 68.22  ?  75  CYS C CA  1 
ATOM   4959 C C   . CYS C 1 81  ? -20.400 -34.474 35.615  1.00 67.32  ?  75  CYS C C   1 
ATOM   4960 O O   . CYS C 1 81  ? -21.519 -34.939 35.390  1.00 67.02  ?  75  CYS C O   1 
ATOM   4961 C CB  . CYS C 1 81  ? -19.500 -36.118 33.976  1.00 61.78  ?  75  CYS C CB  1 
ATOM   4962 S SG  . CYS C 1 81  ? -18.023 -36.983 33.493  1.00 65.72  ?  75  CYS C SG  1 
ATOM   4963 N N   . THR C 1 82  ? -20.163 -33.620 36.599  1.00 68.38  ?  76  THR C N   1 
ATOM   4964 C CA  . THR C 1 82  ? -21.177 -33.187 37.546  1.00 68.30  ?  76  THR C CA  1 
ATOM   4965 C C   . THR C 1 82  ? -21.815 -31.897 37.054  1.00 69.92  ?  76  THR C C   1 
ATOM   4966 O O   . THR C 1 82  ? -21.426 -31.361 36.014  1.00 64.52  ?  76  THR C O   1 
ATOM   4967 C CB  . THR C 1 82  ? -20.540 -33.045 38.928  1.00 69.12  ?  76  THR C CB  1 
ATOM   4968 O OG1 . THR C 1 82  ? -19.324 -32.308 38.816  1.00 68.05  ?  76  THR C OG1 1 
ATOM   4969 C CG2 . THR C 1 82  ? -20.203 -34.426 39.494  1.00 62.93  ?  76  THR C CG2 1 
ATOM   4970 N N   . PRO C 1 83  ? -22.867 -31.410 37.725  1.00 75.13  ?  77  PRO C N   1 
ATOM   4971 C CA  . PRO C 1 83  ? -23.487 -30.149 37.295  1.00 66.89  ?  77  PRO C CA  1 
ATOM   4972 C C   . PRO C 1 83  ? -22.599 -28.956 37.580  1.00 68.76  ?  77  PRO C C   1 
ATOM   4973 O O   . PRO C 1 83  ? -21.781 -28.964 38.506  1.00 67.53  ?  77  PRO C O   1 
ATOM   4974 C CB  . PRO C 1 83  ? -24.779 -30.068 38.113  1.00 62.66  ?  77  PRO C CB  1 
ATOM   4975 C CG  . PRO C 1 83  ? -24.960 -31.361 38.728  1.00 66.62  ?  77  PRO C CG  1 
ATOM   4976 C CD  . PRO C 1 83  ? -23.722 -32.154 38.668  1.00 71.53  ?  77  PRO C CD  1 
ATOM   4977 N N   . THR C 1 84  ? -22.809 -27.909 36.779  1.00 67.43  ?  78  THR C N   1 
ATOM   4978 C CA  . THR C 1 84  ? -21.922 -26.752 36.773  1.00 67.26  ?  78  THR C CA  1 
ATOM   4979 C C   . THR C 1 84  ? -21.687 -26.208 38.174  1.00 70.08  ?  78  THR C C   1 
ATOM   4980 O O   . THR C 1 84  ? -20.547 -26.164 38.640  1.00 69.29  ?  78  THR C O   1 
ATOM   4981 C CB  . THR C 1 84  ? -22.498 -25.680 35.862  1.00 64.98  ?  78  THR C CB  1 
ATOM   4982 O OG1 . THR C 1 84  ? -22.643 -26.215 34.538  1.00 61.47  ?  78  THR C OG1 1 
ATOM   4983 C CG2 . THR C 1 84  ? -21.587 -24.479 35.839  1.00 71.63  ?  78  THR C CG2 1 
ATOM   4984 N N   . ARG C 1 85  ? -22.765 -25.843 38.877  1.00 69.58  ?  79  ARG C N   1 
ATOM   4985 C CA  . ARG C 1 85  ? -22.643 -25.201 40.187  1.00 71.81  ?  79  ARG C CA  1 
ATOM   4986 C C   . ARG C 1 85  ? -21.746 -25.979 41.144  1.00 68.41  ?  79  ARG C C   1 
ATOM   4987 O O   . ARG C 1 85  ? -20.906 -25.396 41.843  1.00 67.28  ?  79  ARG C O   1 
ATOM   4988 C CB  . ARG C 1 85  ? -24.023 -25.010 40.829  1.00 79.25  ?  79  ARG C CB  1 
ATOM   4989 C CG  . ARG C 1 85  ? -24.444 -23.546 40.914  1.00 84.13  ?  79  ARG C CG  1 
ATOM   4990 C CD  . ARG C 1 85  ? -24.074 -22.776 39.635  1.00 81.38  ?  79  ARG C CD  1 
ATOM   4991 N NE  . ARG C 1 85  ? -24.036 -21.331 39.844  1.00 92.45  ?  79  ARG C NE  1 
ATOM   4992 C CZ  . ARG C 1 85  ? -24.133 -20.423 38.878  1.00 95.64  ?  79  ARG C CZ  1 
ATOM   4993 N NH1 . ARG C 1 85  ? -24.535 -20.751 37.660  1.00 100.08 ?  79  ARG C NH1 1 
ATOM   4994 N NH2 . ARG C 1 85  ? -23.827 -19.153 39.141  1.00 88.88  ?  79  ARG C NH2 1 
ATOM   4995 N N   . GLU C 1 86  ? -21.926 -27.295 41.208  1.00 68.11  ?  80  GLU C N   1 
ATOM   4996 C CA  . GLU C 1 86  ? -21.207 -28.117 42.170  1.00 64.02  ?  80  GLU C CA  1 
ATOM   4997 C C   . GLU C 1 86  ? -19.781 -28.432 41.738  1.00 70.18  ?  80  GLU C C   1 
ATOM   4998 O O   . GLU C 1 86  ? -18.981 -28.877 42.572  1.00 69.79  ?  80  GLU C O   1 
ATOM   4999 C CB  . GLU C 1 86  ? -21.957 -29.432 42.403  1.00 70.68  ?  80  GLU C CB  1 
ATOM   5000 C CG  . GLU C 1 86  ? -23.190 -29.332 43.278  1.00 71.48  ?  80  GLU C CG  1 
ATOM   5001 C CD  . GLU C 1 86  ? -24.350 -28.603 42.596  1.00 76.42  ?  80  GLU C CD  1 
ATOM   5002 O OE1 . GLU C 1 86  ? -24.655 -28.893 41.418  1.00 80.13  ?  80  GLU C OE1 1 
ATOM   5003 O OE2 . GLU C 1 86  ? -24.969 -27.734 43.240  1.00 81.35  -1 80  GLU C OE2 1 
ATOM   5004 N N   . THR C 1 87  ? -19.441 -28.217 40.466  1.00 69.16  ?  81  THR C N   1 
ATOM   5005 C CA  . THR C 1 87  ? -18.180 -28.719 39.928  1.00 69.33  ?  81  THR C CA  1 
ATOM   5006 C C   . THR C 1 87  ? -16.955 -28.023 40.519  1.00 69.16  ?  81  THR C C   1 
ATOM   5007 O O   . THR C 1 87  ? -15.976 -28.707 40.862  1.00 69.77  ?  81  THR C O   1 
ATOM   5008 C CB  . THR C 1 87  ? -18.169 -28.598 38.406  1.00 69.48  ?  81  THR C CB  1 
ATOM   5009 O OG1 . THR C 1 87  ? -19.118 -29.515 37.846  1.00 66.84  ?  81  THR C OG1 1 
ATOM   5010 C CG2 . THR C 1 87  ? -16.791 -28.939 37.875  1.00 73.29  ?  81  THR C CG2 1 
ATOM   5011 N N   . PRO C 1 88  ? -16.942 -26.688 40.659  1.00 69.07  ?  82  PRO C N   1 
ATOM   5012 C CA  . PRO C 1 88  ? -15.760 -26.059 41.287  1.00 68.54  ?  82  PRO C CA  1 
ATOM   5013 C C   . PRO C 1 88  ? -15.436 -26.634 42.657  1.00 70.65  ?  82  PRO C C   1 
ATOM   5014 O O   . PRO C 1 88  ? -14.293 -27.053 42.903  1.00 73.39  ?  82  PRO C O   1 
ATOM   5015 C CB  . PRO C 1 88  ? -16.151 -24.580 41.348  1.00 63.65  ?  82  PRO C CB  1 
ATOM   5016 C CG  . PRO C 1 88  ? -17.075 -24.405 40.206  1.00 65.09  ?  82  PRO C CG  1 
ATOM   5017 C CD  . PRO C 1 88  ? -17.894 -25.664 40.188  1.00 67.26  ?  82  PRO C CD  1 
ATOM   5018 N N   . ALA C 1 89  ? -16.428 -26.703 43.547  1.00 68.66  ?  83  ALA C N   1 
ATOM   5019 C CA  . ALA C 1 89  ? -16.195 -27.242 44.883  1.00 68.39  ?  83  ALA C CA  1 
ATOM   5020 C C   . ALA C 1 89  ? -15.685 -28.682 44.829  1.00 69.62  ?  83  ALA C C   1 
ATOM   5021 O O   . ALA C 1 89  ? -14.720 -29.035 45.518  1.00 69.22  ?  83  ALA C O   1 
ATOM   5022 C CB  . ALA C 1 89  ? -17.478 -27.140 45.702  1.00 60.42  ?  83  ALA C CB  1 
ATOM   5023 N N   . ILE C 1 90  ? -16.322 -29.532 44.013  1.00 68.70  ?  84  ILE C N   1 
ATOM   5024 C CA  . ILE C 1 90  ? -15.857 -30.912 43.858  1.00 70.68  ?  84  ILE C CA  1 
ATOM   5025 C C   . ILE C 1 90  ? -14.400 -30.932 43.417  1.00 71.93  ?  84  ILE C C   1 
ATOM   5026 O O   . ILE C 1 90  ? -13.567 -31.651 43.978  1.00 75.65  ?  84  ILE C O   1 
ATOM   5027 C CB  . ILE C 1 90  ? -16.742 -31.671 42.853  1.00 71.08  ?  84  ILE C CB  1 
ATOM   5028 C CG1 . ILE C 1 90  ? -18.087 -32.029 43.470  1.00 70.25  ?  84  ILE C CG1 1 
ATOM   5029 C CG2 . ILE C 1 90  ? -16.053 -32.926 42.388  1.00 66.08  ?  84  ILE C CG2 1 
ATOM   5030 C CD1 . ILE C 1 90  ? -19.116 -32.393 42.449  1.00 68.68  ?  84  ILE C CD1 1 
ATOM   5031 N N   . ALA C 1 91  ? -14.071 -30.131 42.405  1.00 72.55  ?  85  ALA C N   1 
ATOM   5032 C CA  . ALA C 1 91  ? -12.738 -30.186 41.826  1.00 69.59  ?  85  ALA C CA  1 
ATOM   5033 C C   . ALA C 1 91  ? -11.682 -29.797 42.851  1.00 71.01  ?  85  ALA C C   1 
ATOM   5034 O O   . ALA C 1 91  ? -10.659 -30.478 43.000  1.00 70.16  ?  85  ALA C O   1 
ATOM   5035 C CB  . ALA C 1 91  ? -12.683 -29.271 40.605  1.00 73.33  ?  85  ALA C CB  1 
ATOM   5036 N N   . LYS C 1 92  ? -11.919 -28.699 43.576  1.00 71.76  ?  86  LYS C N   1 
ATOM   5037 C CA  . LYS C 1 92  ? -10.965 -28.255 44.584  1.00 70.16  ?  86  LYS C CA  1 
ATOM   5038 C C   . LYS C 1 92  ? -10.664 -29.355 45.596  1.00 77.15  ?  86  LYS C C   1 
ATOM   5039 O O   . LYS C 1 92  ? -9.526  -29.465 46.065  1.00 81.17  ?  86  LYS C O   1 
ATOM   5040 C CB  . LYS C 1 92  ? -11.488 -26.996 45.274  1.00 70.20  ?  86  LYS C CB  1 
ATOM   5041 C CG  . LYS C 1 92  ? -11.549 -25.770 44.348  1.00 71.97  ?  86  LYS C CG  1 
ATOM   5042 C CD  . LYS C 1 92  ? -11.900 -24.490 45.083  1.00 65.21  ?  86  LYS C CD  1 
ATOM   5043 C CE  . LYS C 1 92  ? -12.747 -23.587 44.201  1.00 73.53  ?  86  LYS C CE  1 
ATOM   5044 N NZ  . LYS C 1 92  ? -13.512 -22.541 44.950  1.00 79.31  ?  86  LYS C NZ  1 
ATOM   5045 N N   . GLU C 1 93  ? -11.649 -30.202 45.911  1.00 77.85  ?  87  GLU C N   1 
ATOM   5046 C CA  . GLU C 1 93  ? -11.417 -31.290 46.858  1.00 80.19  ?  87  GLU C CA  1 
ATOM   5047 C C   . GLU C 1 93  ? -10.521 -32.359 46.248  1.00 81.41  ?  87  GLU C C   1 
ATOM   5048 O O   . GLU C 1 93  ? -9.550  -32.804 46.875  1.00 85.66  ?  87  GLU C O   1 
ATOM   5049 C CB  . GLU C 1 93  ? -12.758 -31.881 47.311  1.00 82.40  ?  87  GLU C CB  1 
ATOM   5050 C CG  . GLU C 1 93  ? -12.719 -33.112 48.251  1.00 91.79  ?  87  GLU C CG  1 
ATOM   5051 C CD  . GLU C 1 93  ? -11.417 -33.279 49.048  1.00 99.88  ?  87  GLU C CD  1 
ATOM   5052 O OE1 . GLU C 1 93  ? -11.094 -32.404 49.889  1.00 100.32 ?  87  GLU C OE1 1 
ATOM   5053 O OE2 . GLU C 1 93  ? -10.727 -34.308 48.848  1.00 101.09 -1 87  GLU C OE2 1 
ATOM   5054 N N   . LEU C 1 94  ? -10.822 -32.777 45.018  1.00 79.52  ?  88  LEU C N   1 
ATOM   5055 C CA  . LEU C 1 94  ? -10.025 -33.820 44.378  1.00 76.39  ?  88  LEU C CA  1 
ATOM   5056 C C   . LEU C 1 94  ? -8.610  -33.341 44.068  1.00 76.65  ?  88  LEU C C   1 
ATOM   5057 O O   . LEU C 1 94  ? -7.660  -34.133 44.140  1.00 77.56  ?  88  LEU C O   1 
ATOM   5058 C CB  . LEU C 1 94  ? -10.727 -34.302 43.110  1.00 71.37  ?  88  LEU C CB  1 
ATOM   5059 C CG  . LEU C 1 94  ? -11.920 -35.260 43.249  1.00 78.91  ?  88  LEU C CG  1 
ATOM   5060 C CD1 . LEU C 1 94  ? -13.071 -34.729 44.132  1.00 82.07  ?  88  LEU C CD1 1 
ATOM   5061 C CD2 . LEU C 1 94  ? -12.456 -35.597 41.877  1.00 76.16  ?  88  LEU C CD2 1 
ATOM   5062 N N   . LEU C 1 95  ? -8.444  -32.059 43.733  1.00 71.93  ?  89  LEU C N   1 
ATOM   5063 C CA  . LEU C 1 95  ? -7.102  -31.529 43.513  1.00 75.35  ?  89  LEU C CA  1 
ATOM   5064 C C   . LEU C 1 95  ? -6.278  -31.599 44.789  1.00 80.73  ?  89  LEU C C   1 
ATOM   5065 O O   . LEU C 1 95  ? -5.111  -32.014 44.768  1.00 83.15  ?  89  LEU C O   1 
ATOM   5066 C CB  . LEU C 1 95  ? -7.169  -30.086 43.012  1.00 73.09  ?  89  LEU C CB  1 
ATOM   5067 C CG  . LEU C 1 95  ? -7.675  -29.852 41.591  1.00 70.18  ?  89  LEU C CG  1 
ATOM   5068 C CD1 . LEU C 1 95  ? -7.823  -28.373 41.306  1.00 64.15  ?  89  LEU C CD1 1 
ATOM   5069 C CD2 . LEU C 1 95  ? -6.760  -30.524 40.569  1.00 68.44  ?  89  LEU C CD2 1 
ATOM   5070 N N   . ALA C 1 96  ? -6.883  -31.224 45.921  1.00 81.80  ?  90  ALA C N   1 
ATOM   5071 C CA  . ALA C 1 96  ? -6.182  -31.222 47.199  1.00 83.56  ?  90  ALA C CA  1 
ATOM   5072 C C   . ALA C 1 96  ? -5.671  -32.600 47.590  1.00 83.65  ?  90  ALA C C   1 
ATOM   5073 O O   . ALA C 1 96  ? -4.881  -32.705 48.534  1.00 85.23  ?  90  ALA C O   1 
ATOM   5074 C CB  . ALA C 1 96  ? -7.099  -30.672 48.290  1.00 81.82  ?  90  ALA C CB  1 
ATOM   5075 N N   . ARG C 1 97  ? -6.093  -33.648 46.889  1.00 83.48  ?  91  ARG C N   1 
ATOM   5076 C CA  . ARG C 1 97  ? -5.657  -35.011 47.138  1.00 76.61  ?  91  ARG C CA  1 
ATOM   5077 C C   . ARG C 1 97  ? -4.607  -35.466 46.136  1.00 80.16  ?  91  ARG C C   1 
ATOM   5078 O O   . ARG C 1 97  ? -4.237  -36.645 46.128  1.00 80.12  ?  91  ARG C O   1 
ATOM   5079 C CB  . ARG C 1 97  ? -6.869  -35.939 47.109  1.00 83.56  ?  91  ARG C CB  1 
ATOM   5080 C CG  . ARG C 1 97  ? -6.774  -37.182 47.975  1.00 87.91  ?  91  ARG C CG  1 
ATOM   5081 C CD  . ARG C 1 97  ? -8.089  -37.921 47.912  1.00 88.73  ?  91  ARG C CD  1 
ATOM   5082 N NE  . ARG C 1 97  ? -9.207  -37.018 48.169  1.00 90.27  ?  91  ARG C NE  1 
ATOM   5083 C CZ  . ARG C 1 97  ? -10.440 -37.413 48.471  1.00 91.77  ?  91  ARG C CZ  1 
ATOM   5084 N NH1 . ARG C 1 97  ? -10.766 -38.697 48.514  1.00 85.52  ?  91  ARG C NH1 1 
ATOM   5085 N NH2 . ARG C 1 97  ? -11.370 -36.496 48.736  1.00 91.71  ?  91  ARG C NH2 1 
ATOM   5086 N N   . GLY C 1 98  ? -4.119  -34.559 45.285  1.00 79.59  ?  92  GLY C N   1 
ATOM   5087 C CA  . GLY C 1 98  ? -3.105  -34.895 44.310  1.00 76.50  ?  92  GLY C CA  1 
ATOM   5088 C C   . GLY C 1 98  ? -3.623  -35.353 42.963  1.00 77.94  ?  92  GLY C C   1 
ATOM   5089 O O   . GLY C 1 98  ? -2.828  -35.467 42.018  1.00 78.06  ?  92  GLY C O   1 
ATOM   5090 N N   . ILE C 1 99  ? -4.926  -35.601 42.833  1.00 77.14  ?  93  ILE C N   1 
ATOM   5091 C CA  . ILE C 1 99  ? -5.501  -36.069 41.577  1.00 74.10  ?  93  ILE C CA  1 
ATOM   5092 C C   . ILE C 1 99  ? -5.727  -34.885 40.646  1.00 71.35  ?  93  ILE C C   1 
ATOM   5093 O O   . ILE C 1 99  ? -6.159  -33.798 41.065  1.00 65.51  ?  93  ILE C O   1 
ATOM   5094 C CB  . ILE C 1 99  ? -6.813  -36.834 41.837  1.00 73.17  ?  93  ILE C CB  1 
ATOM   5095 C CG1 . ILE C 1 99  ? -6.592  -37.900 42.903  1.00 70.68  ?  93  ILE C CG1 1 
ATOM   5096 C CG2 . ILE C 1 99  ? -7.336  -37.476 40.554  1.00 69.26  ?  93  ILE C CG2 1 
ATOM   5097 C CD1 . ILE C 1 99  ? -7.370  -37.665 44.145  1.00 76.49  ?  93  ILE C CD1 1 
ATOM   5098 N N   . HIS C 1 100 ? -5.422  -35.094 39.372  1.00 69.71  ?  94  HIS C N   1 
ATOM   5099 C CA  . HIS C 1 100 ? -5.751  -34.100 38.368  1.00 69.70  ?  94  HIS C CA  1 
ATOM   5100 C C   . HIS C 1 100 ? -7.258  -34.096 38.119  1.00 67.45  ?  94  HIS C C   1 
ATOM   5101 O O   . HIS C 1 100 ? -7.956  -35.080 38.366  1.00 65.57  ?  94  HIS C O   1 
ATOM   5102 C CB  . HIS C 1 100 ? -5.000  -34.390 37.072  1.00 70.30  ?  94  HIS C CB  1 
ATOM   5103 C CG  . HIS C 1 100 ? -3.525  -34.586 37.256  1.00 73.08  ?  94  HIS C CG  1 
ATOM   5104 N ND1 . HIS C 1 100 ? -2.750  -33.740 38.027  1.00 71.01  ?  94  HIS C ND1 1 
ATOM   5105 C CD2 . HIS C 1 100 ? -2.678  -35.519 36.752  1.00 64.73  ?  94  HIS C CD2 1 
ATOM   5106 C CE1 . HIS C 1 100 ? -1.493  -34.145 37.989  1.00 68.70  ?  94  HIS C CE1 1 
ATOM   5107 N NE2 . HIS C 1 100 ? -1.423  -35.224 37.227  1.00 59.49  ?  94  HIS C NE2 1 
ATOM   5108 N N   . THR C 1 101 ? -7.765  -32.966 37.640  1.00 67.53  ?  95  THR C N   1 
ATOM   5109 C CA  . THR C 1 101 ? -9.191  -32.831 37.392  1.00 68.41  ?  95  THR C CA  1 
ATOM   5110 C C   . THR C 1 101 ? -9.450  -32.238 36.012  1.00 65.95  ?  95  THR C C   1 
ATOM   5111 O O   . THR C 1 101 ? -8.708  -31.360 35.546  1.00 63.32  ?  95  THR C O   1 
ATOM   5112 C CB  . THR C 1 101 ? -9.873  -31.976 38.474  1.00 67.18  ?  95  THR C CB  1 
ATOM   5113 O OG1 . THR C 1 101 ? -9.386  -30.632 38.413  1.00 69.32  ?  95  THR C OG1 1 
ATOM   5114 C CG2 . THR C 1 101 ? -9.638  -32.573 39.864  1.00 64.41  ?  95  THR C CG2 1 
ATOM   5115 N N   . ILE C 1 102 ? -10.493 -32.753 35.353  1.00 61.45  ?  96  ILE C N   1 
ATOM   5116 C CA  . ILE C 1 102 ? -11.002 -32.204 34.102  1.00 65.55  ?  96  ILE C CA  1 
ATOM   5117 C C   . ILE C 1 102 ? -12.472 -31.864 34.290  1.00 61.10  ?  96  ILE C C   1 
ATOM   5118 O O   . ILE C 1 102 ? -13.214 -32.593 34.952  1.00 65.68  ?  96  ILE C O   1 
ATOM   5119 C CB  . ILE C 1 102 ? -10.847 -33.160 32.900  1.00 63.93  ?  96  ILE C CB  1 
ATOM   5120 C CG1 . ILE C 1 102 ? -9.481  -33.874 32.899  1.00 64.63  ?  96  ILE C CG1 1 
ATOM   5121 C CG2 . ILE C 1 102 ? -11.149 -32.398 31.601  1.00 57.44  ?  96  ILE C CG2 1 
ATOM   5122 C CD1 . ILE C 1 102 ? -8.256  -32.970 32.718  1.00 64.24  ?  96  ILE C CD1 1 
ATOM   5123 N N   . ASP C 1 103 ? -12.893 -30.764 33.698  1.00 54.14  ?  97  ASP C N   1 
ATOM   5124 C CA  . ASP C 1 103 ? -14.287 -30.385 33.743  1.00 61.28  ?  97  ASP C CA  1 
ATOM   5125 C C   . ASP C 1 103 ? -14.578 -29.576 32.493  1.00 66.58  ?  97  ASP C C   1 
ATOM   5126 O O   . ASP C 1 103 ? -13.662 -29.087 31.819  1.00 64.66  ?  97  ASP C O   1 
ATOM   5127 C CB  . ASP C 1 103 ? -14.628 -29.595 35.002  1.00 59.89  ?  97  ASP C CB  1 
ATOM   5128 C CG  . ASP C 1 103 ? -14.176 -28.150 34.913  1.00 67.04  ?  97  ASP C CG  1 
ATOM   5129 O OD1 . ASP C 1 103 ? -14.569 -27.446 33.951  1.00 68.76  -1 97  ASP C OD1 1 
ATOM   5130 O OD2 . ASP C 1 103 ? -13.421 -27.712 35.809  1.00 67.72  ?  97  ASP C OD2 1 
ATOM   5131 N N   . SER C 1 104 ? -15.871 -29.433 32.196  1.00 66.06  ?  98  SER C N   1 
ATOM   5132 C CA  . SER C 1 104 ? -16.348 -28.666 31.052  1.00 65.91  ?  98  SER C CA  1 
ATOM   5133 C C   . SER C 1 104 ? -17.278 -27.547 31.499  1.00 62.16  ?  98  SER C C   1 
ATOM   5134 O O   . SER C 1 104 ? -18.239 -27.215 30.797  1.00 58.20  ?  98  SER C O   1 
ATOM   5135 C CB  . SER C 1 104 ? -17.054 -29.577 30.050  1.00 63.22  ?  98  SER C CB  1 
ATOM   5136 O OG  . SER C 1 104 ? -18.116 -30.235 30.708  1.00 63.84  ?  98  SER C OG  1 
ATOM   5137 N N   . PHE C 1 105 ? -17.019 -27.005 32.691  1.00 60.70  ?  99  PHE C N   1 
ATOM   5138 C CA  . PHE C 1 105 ? -17.672 -25.817 33.242  1.00 65.85  ?  99  PHE C CA  1 
ATOM   5139 C C   . PHE C 1 105 ? -18.127 -24.842 32.150  1.00 67.49  ?  99  PHE C C   1 
ATOM   5140 O O   . PHE C 1 105 ? -17.309 -24.396 31.331  1.00 62.06  ?  99  PHE C O   1 
ATOM   5141 C CB  . PHE C 1 105 ? -16.698 -25.156 34.217  1.00 62.40  ?  99  PHE C CB  1 
ATOM   5142 C CG  . PHE C 1 105 ? -17.308 -24.110 35.076  1.00 63.67  ?  99  PHE C CG  1 
ATOM   5143 C CD1 . PHE C 1 105 ? -17.361 -22.797 34.653  1.00 65.86  ?  99  PHE C CD1 1 
ATOM   5144 C CD2 . PHE C 1 105 ? -17.800 -24.426 36.327  1.00 67.51  ?  99  PHE C CD2 1 
ATOM   5145 C CE1 . PHE C 1 105 ? -17.922 -21.818 35.461  1.00 69.17  ?  99  PHE C CE1 1 
ATOM   5146 C CE2 . PHE C 1 105 ? -18.362 -23.461 37.133  1.00 62.20  ?  99  PHE C CE2 1 
ATOM   5147 C CZ  . PHE C 1 105 ? -18.426 -22.162 36.703  1.00 66.36  ?  99  PHE C CZ  1 
ATOM   5148 N N   . ASP C 1 106 ? -19.428 -24.518 32.095  1.00 64.10  ?  100 ASP C N   1 
ATOM   5149 C CA  . ASP C 1 106 ? -19.965 -23.883 30.891  1.00 65.65  ?  100 ASP C CA  1 
ATOM   5150 C C   . ASP C 1 106 ? -20.550 -22.485 31.117  1.00 62.07  ?  100 ASP C C   1 
ATOM   5151 O O   . ASP C 1 106 ? -21.239 -21.966 30.232  1.00 65.18  ?  100 ASP C O   1 
ATOM   5152 C CB  . ASP C 1 106 ? -20.989 -24.799 30.209  1.00 65.93  ?  100 ASP C CB  1 
ATOM   5153 C CG  . ASP C 1 106 ? -22.199 -25.116 31.084  1.00 66.13  ?  100 ASP C CG  1 
ATOM   5154 O OD1 . ASP C 1 106 ? -22.284 -24.594 32.218  1.00 64.32  ?  100 ASP C OD1 1 
ATOM   5155 O OD2 . ASP C 1 106 ? -23.067 -25.905 30.621  1.00 64.80  -1 100 ASP C OD2 1 
ATOM   5156 N N   . ILE C 1 107 ? -20.238 -21.839 32.238  1.00 56.72  ?  101 ILE C N   1 
ATOM   5157 C CA  . ILE C 1 107 ? -20.617 -20.455 32.504  1.00 63.56  ?  101 ILE C CA  1 
ATOM   5158 C C   . ILE C 1 107 ? -19.439 -19.567 32.103  1.00 67.77  ?  101 ILE C C   1 
ATOM   5159 O O   . ILE C 1 107 ? -18.460 -19.437 32.847  1.00 71.25  ?  101 ILE C O   1 
ATOM   5160 C CB  . ILE C 1 107 ? -20.972 -20.246 33.976  1.00 67.46  ?  101 ILE C CB  1 
ATOM   5161 C CG1 . ILE C 1 107 ? -22.285 -20.940 34.310  1.00 75.64  ?  101 ILE C CG1 1 
ATOM   5162 C CG2 . ILE C 1 107 ? -21.094 -18.765 34.284  1.00 70.77  ?  101 ILE C CG2 1 
ATOM   5163 C CD1 . ILE C 1 107 ? -22.548 -20.991 35.771  1.00 77.45  ?  101 ILE C CD1 1 
ATOM   5164 N N   . HIS C 1 108 ? -19.556 -18.897 30.955  1.00 66.31  ?  102 HIS C N   1 
ATOM   5165 C CA  . HIS C 1 108 ? -18.428 -18.153 30.400  1.00 68.51  ?  102 HIS C CA  1 
ATOM   5166 C C   . HIS C 1 108 ? -17.877 -17.112 31.376  1.00 69.46  ?  102 HIS C C   1 
ATOM   5167 O O   . HIS C 1 108 ? -16.658 -17.025 31.567  1.00 65.80  ?  102 HIS C O   1 
ATOM   5168 C CB  . HIS C 1 108 ? -18.838 -17.520 29.072  1.00 60.21  ?  102 HIS C CB  1 
ATOM   5169 C CG  . HIS C 1 108 ? -18.946 -18.516 27.965  1.00 65.40  ?  102 HIS C CG  1 
ATOM   5170 N ND1 . HIS C 1 108 ? -17.840 -19.084 27.367  1.00 64.02  ?  102 HIS C ND1 1 
ATOM   5171 C CD2 . HIS C 1 108 ? -20.022 -19.099 27.390  1.00 70.80  ?  102 HIS C CD2 1 
ATOM   5172 C CE1 . HIS C 1 108 ? -18.231 -19.945 26.445  1.00 63.25  ?  102 HIS C CE1 1 
ATOM   5173 N NE2 . HIS C 1 108 ? -19.551 -19.976 26.441  1.00 72.33  ?  102 HIS C NE2 1 
ATOM   5174 N N   . GLN C 1 109 ? -18.751 -16.330 32.025  1.00 68.60  ?  103 GLN C N   1 
ATOM   5175 C CA  . GLN C 1 109 ? -18.257 -15.200 32.818  1.00 64.42  ?  103 GLN C CA  1 
ATOM   5176 C C   . GLN C 1 109 ? -17.595 -15.617 34.121  1.00 65.19  ?  103 GLN C C   1 
ATOM   5177 O O   . GLN C 1 109 ? -16.948 -14.788 34.760  1.00 69.29  ?  103 GLN C O   1 
ATOM   5178 C CB  . GLN C 1 109 ? -19.383 -14.230 33.169  1.00 69.90  ?  103 GLN C CB  1 
ATOM   5179 C CG  . GLN C 1 109 ? -20.270 -13.918 32.014  1.00 80.90  ?  103 GLN C CG  1 
ATOM   5180 C CD  . GLN C 1 109 ? -21.633 -14.519 32.200  1.00 89.39  ?  103 GLN C CD  1 
ATOM   5181 O OE1 . GLN C 1 109 ? -22.361 -14.195 33.150  1.00 97.89  ?  103 GLN C OE1 1 
ATOM   5182 N NE2 . GLN C 1 109 ? -21.951 -15.494 31.341  1.00 78.14  ?  103 GLN C NE2 1 
ATOM   5183 N N   . GLU C 1 110 ? -17.766 -16.841 34.577  1.00 65.50  ?  104 GLU C N   1 
ATOM   5184 C CA  . GLU C 1 110 ? -17.124 -17.188 35.831  1.00 67.76  ?  104 GLU C CA  1 
ATOM   5185 C C   . GLU C 1 110 ? -15.838 -17.964 35.620  1.00 64.74  ?  104 GLU C C   1 
ATOM   5186 O O   . GLU C 1 110 ? -15.180 -18.337 36.599  1.00 64.54  ?  104 GLU C O   1 
ATOM   5187 C CB  . GLU C 1 110 ? -18.089 -17.964 36.725  1.00 67.42  ?  104 GLU C CB  1 
ATOM   5188 C CG  . GLU C 1 110 ? -19.241 -17.113 37.256  1.00 66.32  ?  104 GLU C CG  1 
ATOM   5189 C CD  . GLU C 1 110 ? -20.441 -17.975 37.668  1.00 81.85  ?  104 GLU C CD  1 
ATOM   5190 O OE1 . GLU C 1 110 ? -20.208 -19.143 38.063  1.00 80.34  ?  104 GLU C OE1 1 
ATOM   5191 O OE2 . GLU C 1 110 ? -21.604 -17.499 37.592  1.00 80.51  -1 104 GLU C OE2 1 
ATOM   5192 N N   . ILE C 1 111 ? -15.455 -18.184 34.361  1.00 63.69  ?  105 ILE C N   1 
ATOM   5193 C CA  . ILE C 1 111 ? -14.299 -19.016 34.060  1.00 63.80  ?  105 ILE C CA  1 
ATOM   5194 C C   . ILE C 1 111 ? -13.015 -18.378 34.588  1.00 64.52  ?  105 ILE C C   1 
ATOM   5195 O O   . ILE C 1 111 ? -12.186 -19.066 35.198  1.00 63.43  ?  105 ILE C O   1 
ATOM   5196 C CB  . ILE C 1 111 ? -14.220 -19.286 32.550  1.00 63.67  ?  105 ILE C CB  1 
ATOM   5197 C CG1 . ILE C 1 111 ? -15.255 -20.331 32.159  1.00 64.27  ?  105 ILE C CG1 1 
ATOM   5198 C CG2 . ILE C 1 111 ? -12.807 -19.740 32.160  1.00 58.55  ?  105 ILE C CG2 1 
ATOM   5199 C CD1 . ILE C 1 111 ? -15.419 -20.478 30.667  1.00 67.18  ?  105 ILE C CD1 1 
ATOM   5200 N N   . VAL C 1 112 ? -12.832 -17.063 34.362  1.00 59.04  ?  106 VAL C N   1 
ATOM   5201 C CA  . VAL C 1 112 ? -11.621 -16.376 34.829  1.00 63.34  ?  106 VAL C CA  1 
ATOM   5202 C C   . VAL C 1 112 ? -11.469 -16.535 36.335  1.00 65.47  ?  106 VAL C C   1 
ATOM   5203 O O   . VAL C 1 112 ? -10.366 -16.807 36.840  1.00 61.48  ?  106 VAL C O   1 
ATOM   5204 C CB  . VAL C 1 112 ? -11.614 -14.881 34.427  1.00 61.52  ?  106 VAL C CB  1 
ATOM   5205 C CG1 . VAL C 1 112 ? -10.666 -14.083 35.318  1.00 59.36  ?  106 VAL C CG1 1 
ATOM   5206 C CG2 . VAL C 1 112 ? -11.178 -14.695 32.981  1.00 62.63  ?  106 VAL C CG2 1 
ATOM   5207 N N   . GLN C 1 113 ? -12.576 -16.401 37.078  1.00 64.86  ?  107 GLN C N   1 
ATOM   5208 C CA  . GLN C 1 113 ? -12.482 -16.520 38.530  1.00 64.77  ?  107 GLN C CA  1 
ATOM   5209 C C   . GLN C 1 113 ? -12.221 -17.954 38.952  1.00 65.94  ?  107 GLN C C   1 
ATOM   5210 O O   . GLN C 1 113 ? -11.460 -18.207 39.894  1.00 68.83  ?  107 GLN C O   1 
ATOM   5211 C CB  . GLN C 1 113 ? -13.743 -16.006 39.199  1.00 64.51  ?  107 GLN C CB  1 
ATOM   5212 C CG  . GLN C 1 113 ? -13.665 -16.189 40.696  1.00 74.33  ?  107 GLN C CG  1 
ATOM   5213 C CD  . GLN C 1 113 ? -14.727 -15.413 41.441  1.00 82.06  ?  107 GLN C CD  1 
ATOM   5214 O OE1 . GLN C 1 113 ? -15.518 -14.676 40.840  1.00 84.85  ?  107 GLN C OE1 1 
ATOM   5215 N NE2 . GLN C 1 113 ? -14.751 -15.572 42.763  1.00 77.65  ?  107 GLN C NE2 1 
ATOM   5216 N N   . VAL C 1 114 ? -12.826 -18.909 38.256  1.00 63.90  ?  108 VAL C N   1 
ATOM   5217 C CA  . VAL C 1 114 ? -12.698 -20.293 38.675  1.00 64.97  ?  108 VAL C CA  1 
ATOM   5218 C C   . VAL C 1 114 ? -11.307 -20.818 38.354  1.00 66.04  ?  108 VAL C C   1 
ATOM   5219 O O   . VAL C 1 114 ? -10.727 -21.608 39.114  1.00 66.62  ?  108 VAL C O   1 
ATOM   5220 C CB  . VAL C 1 114 ? -13.802 -21.123 38.008  1.00 65.42  ?  108 VAL C CB  1 
ATOM   5221 C CG1 . VAL C 1 114 ? -13.534 -22.607 38.199  1.00 51.71  ?  108 VAL C CG1 1 
ATOM   5222 C CG2 . VAL C 1 114 ? -15.144 -20.690 38.576  1.00 63.55  ?  108 VAL C CG2 1 
ATOM   5223 N N   . ARG C 1 115 ? -10.752 -20.393 37.219  1.00 64.05  ?  109 ARG C N   1 
ATOM   5224 C CA  . ARG C 1 115 ? -9.365  -20.711 36.903  1.00 67.14  ?  109 ARG C CA  1 
ATOM   5225 C C   . ARG C 1 115 ? -8.442  -20.310 38.056  1.00 67.79  ?  109 ARG C C   1 
ATOM   5226 O O   . ARG C 1 115 ? -7.650  -21.128 38.546  1.00 65.28  ?  109 ARG C O   1 
ATOM   5227 C CB  . ARG C 1 115 ? -8.971  -20.014 35.602  1.00 59.84  ?  109 ARG C CB  1 
ATOM   5228 C CG  . ARG C 1 115 ? -7.824  -20.642 34.881  1.00 63.24  ?  109 ARG C CG  1 
ATOM   5229 C CD  . ARG C 1 115 ? -7.051  -19.588 34.069  1.00 66.30  ?  109 ARG C CD  1 
ATOM   5230 N NE  . ARG C 1 115 ? -5.630  -19.760 34.327  1.00 69.89  ?  109 ARG C NE  1 
ATOM   5231 C CZ  . ARG C 1 115 ? -4.982  -19.154 35.311  1.00 71.52  ?  109 ARG C CZ  1 
ATOM   5232 N NH1 . ARG C 1 115 ? -5.569  -18.226 36.051  1.00 70.67  ?  109 ARG C NH1 1 
ATOM   5233 N NH2 . ARG C 1 115 ? -3.722  -19.497 35.568  1.00 81.05  ?  109 ARG C NH2 1 
ATOM   5234 N N   . HIS C 1 116 ? -8.569  -19.061 38.530  1.00 65.20  ?  110 HIS C N   1 
ATOM   5235 C CA  . HIS C 1 116 ? -7.747  -18.596 39.644  1.00 65.95  ?  110 HIS C CA  1 
ATOM   5236 C C   . HIS C 1 116 ? -8.005  -19.424 40.893  1.00 69.27  ?  110 HIS C C   1 
ATOM   5237 O O   . HIS C 1 116 ? -7.065  -19.835 41.585  1.00 70.31  ?  110 HIS C O   1 
ATOM   5238 C CB  . HIS C 1 116 ? -8.016  -17.119 39.930  1.00 63.14  ?  110 HIS C CB  1 
ATOM   5239 C CG  . HIS C 1 116 ? -7.403  -16.182 38.939  1.00 65.53  ?  110 HIS C CG  1 
ATOM   5240 N ND1 . HIS C 1 116 ? -6.041  -16.098 38.735  1.00 67.38  ?  110 HIS C ND1 1 
ATOM   5241 C CD2 . HIS C 1 116 ? -7.964  -15.262 38.117  1.00 65.16  ?  110 HIS C CD2 1 
ATOM   5242 C CE1 . HIS C 1 116 ? -5.794  -15.177 37.818  1.00 64.64  ?  110 HIS C CE1 1 
ATOM   5243 N NE2 . HIS C 1 116 ? -6.943  -14.656 37.426  1.00 57.86  ?  110 HIS C NE2 1 
ATOM   5244 N N   . GLU C 1 117 ? -9.280  -19.687 41.189  1.00 69.76  ?  111 GLU C N   1 
ATOM   5245 C CA  . GLU C 1 117 ? -9.619  -20.468 42.377  1.00 72.73  ?  111 GLU C CA  1 
ATOM   5246 C C   . GLU C 1 117 ? -9.078  -21.885 42.284  1.00 70.98  ?  111 GLU C C   1 
ATOM   5247 O O   . GLU C 1 117 ? -8.514  -22.406 43.253  1.00 75.90  ?  111 GLU C O   1 
ATOM   5248 C CB  . GLU C 1 117 ? -11.129 -20.479 42.582  1.00 67.78  ?  111 GLU C CB  1 
ATOM   5249 C CG  . GLU C 1 117 ? -11.668 -19.124 42.929  1.00 69.72  ?  111 GLU C CG  1 
ATOM   5250 C CD  . GLU C 1 117 ? -13.145 -19.147 43.167  1.00 79.93  ?  111 GLU C CD  1 
ATOM   5251 O OE1 . GLU C 1 117 ? -13.713 -20.267 43.228  1.00 85.04  ?  111 GLU C OE1 1 
ATOM   5252 O OE2 . GLU C 1 117 ? -13.738 -18.048 43.290  1.00 81.38  -1 111 GLU C OE2 1 
ATOM   5253 N N   . LEU C 1 118 ? -9.235  -22.525 41.127  1.00 69.00  ?  112 LEU C N   1 
ATOM   5254 C CA  . LEU C 1 118 ? -8.636  -23.841 40.934  1.00 69.73  ?  112 LEU C CA  1 
ATOM   5255 C C   . LEU C 1 118 ? -7.117  -23.781 40.886  1.00 69.83  ?  112 LEU C C   1 
ATOM   5256 O O   . LEU C 1 118 ? -6.455  -24.722 41.353  1.00 74.35  ?  112 LEU C O   1 
ATOM   5257 C CB  . LEU C 1 118 ? -9.179  -24.499 39.662  1.00 71.55  ?  112 LEU C CB  1 
ATOM   5258 C CG  . LEU C 1 118 ? -10.669 -24.831 39.557  1.00 67.40  ?  112 LEU C CG  1 
ATOM   5259 C CD1 . LEU C 1 118 ? -10.861 -25.844 38.473  1.00 69.88  ?  112 LEU C CD1 1 
ATOM   5260 C CD2 . LEU C 1 118 ? -11.159 -25.397 40.859  1.00 63.69  ?  112 LEU C CD2 1 
ATOM   5261 N N   . ASP C 1 119 ? -6.545  -22.706 40.326  1.00 69.25  ?  113 ASP C N   1 
ATOM   5262 C CA  . ASP C 1 119 ? -5.084  -22.596 40.243  1.00 71.08  ?  113 ASP C CA  1 
ATOM   5263 C C   . ASP C 1 119 ? -4.436  -22.729 41.614  1.00 66.34  ?  113 ASP C C   1 
ATOM   5264 O O   . ASP C 1 119 ? -3.455  -23.460 41.772  1.00 61.13  ?  113 ASP C O   1 
ATOM   5265 C CB  . ASP C 1 119 ? -4.677  -21.266 39.599  1.00 72.40  ?  113 ASP C CB  1 
ATOM   5266 C CG  . ASP C 1 119 ? -3.184  -21.204 39.259  1.00 74.14  ?  113 ASP C CG  1 
ATOM   5267 O OD1 . ASP C 1 119 ? -2.682  -22.125 38.582  1.00 69.14  ?  113 ASP C OD1 1 
ATOM   5268 O OD2 . ASP C 1 119 ? -2.515  -20.223 39.659  1.00 80.18  -1 113 ASP C OD2 1 
ATOM   5269 N N   . GLU C 1 120 ? -4.994  -22.041 42.621  1.00 70.00  ?  114 GLU C N   1 
ATOM   5270 C CA  . GLU C 1 120 ? -4.378  -21.983 43.946  1.00 71.28  ?  114 GLU C CA  1 
ATOM   5271 C C   . GLU C 1 120 ? -4.273  -23.367 44.569  1.00 75.97  ?  114 GLU C C   1 
ATOM   5272 O O   . GLU C 1 120 ? -3.229  -23.741 45.114  1.00 79.32  ?  114 GLU C O   1 
ATOM   5273 C CB  . GLU C 1 120 ? -5.173  -21.053 44.856  1.00 71.43  ?  114 GLU C CB  1 
ATOM   5274 C CG  . GLU C 1 120 ? -5.419  -19.678 44.246  1.00 77.61  ?  114 GLU C CG  1 
ATOM   5275 C CD  . GLU C 1 120 ? -6.330  -18.790 45.099  1.00 94.25  ?  114 GLU C CD  1 
ATOM   5276 O OE1 . GLU C 1 120 ? -6.697  -19.205 46.225  1.00 95.12  ?  114 GLU C OE1 1 
ATOM   5277 O OE2 . GLU C 1 120 ? -6.687  -17.675 44.635  1.00 101.04 -1 114 GLU C OE2 1 
ATOM   5278 N N   . VAL C 1 121 ? -5.344  -24.147 44.499  1.00 73.36  ?  115 VAL C N   1 
ATOM   5279 C CA  . VAL C 1 121 ? -5.298  -25.469 45.101  1.00 74.31  ?  115 VAL C CA  1 
ATOM   5280 C C   . VAL C 1 121 ? -4.331  -26.364 44.345  1.00 78.07  ?  115 VAL C C   1 
ATOM   5281 O O   . VAL C 1 121 ? -3.540  -27.103 44.951  1.00 77.64  ?  115 VAL C O   1 
ATOM   5282 C CB  . VAL C 1 121 ? -6.706  -26.073 45.145  1.00 68.48  ?  115 VAL C CB  1 
ATOM   5283 C CG1 . VAL C 1 121 ? -6.668  -27.356 45.900  1.00 69.22  ?  115 VAL C CG1 1 
ATOM   5284 C CG2 . VAL C 1 121 ? -7.647  -25.091 45.791  1.00 73.13  ?  115 VAL C CG2 1 
ATOM   5285 N N   . ALA C 1 122 ? -4.390  -26.323 43.022  1.00 74.18  ?  116 ALA C N   1 
ATOM   5286 C CA  . ALA C 1 122 ? -3.579  -27.268 42.222  1.00 74.27  ?  116 ALA C CA  1 
ATOM   5287 C C   . ALA C 1 122 ? -2.077  -27.060 42.420  1.00 71.70  ?  116 ALA C C   1 
ATOM   5288 O O   . ALA C 1 122 ? -1.358  -28.064 42.575  1.00 71.34  ?  116 ALA C O   1 
ATOM   5289 C CB  . ALA C 1 122 ? -3.970  -27.115 40.774  1.00 67.97  ?  116 ALA C CB  1 
ATOM   5290 N N   . ARG C 1 123 ? -1.609  -25.812 42.413  1.00 30.00  ?  117 ARG C N   1 
ATOM   5291 C CA  . ARG C 1 123 ? -0.145  -25.556 42.474  1.00 30.00  ?  117 ARG C CA  1 
ATOM   5292 C C   . ARG C 1 123 ? 0.417   -26.056 43.810  1.00 30.00  ?  117 ARG C C   1 
ATOM   5293 O O   . ARG C 1 123 ? 1.617   -26.387 43.865  1.00 30.00  ?  117 ARG C O   1 
ATOM   5294 C CB  . ARG C 1 123 ? 0.172   -24.074 42.244  1.00 30.00  ?  117 ARG C CB  1 
ATOM   5295 C CG  . ARG C 1 123 ? -0.521  -23.101 43.185  1.00 30.00  ?  117 ARG C CG  1 
ATOM   5296 C CD  . ARG C 1 123 ? -0.193  -21.671 42.803  1.00 30.00  ?  117 ARG C CD  1 
ATOM   5297 N NE  . ARG C 1 123 ? -1.351  -20.948 42.269  1.00 30.00  ?  117 ARG C NE  1 
ATOM   5298 C CZ  . ARG C 1 123 ? -1.776  -19.784 42.738  1.00 30.00  ?  117 ARG C CZ  1 
ATOM   5299 N NH1 . ARG C 1 123 ? -2.651  -19.075 42.049  1.00 30.00  ?  117 ARG C NH1 1 
ATOM   5300 N NH2 . ARG C 1 123 ? -1.324  -19.334 43.894  1.00 30.00  ?  117 ARG C NH2 1 
ATOM   5301 N N   . ALA C 1 124 ? -0.429  -26.127 44.831  1.00 73.02  ?  118 ALA C N   1 
ATOM   5302 C CA  . ALA C 1 124 ? 0.032   -26.570 46.159  1.00 73.98  ?  118 ALA C CA  1 
ATOM   5303 C C   . ALA C 1 124 ? 0.162   -28.086 46.193  1.00 79.41  ?  118 ALA C C   1 
ATOM   5304 O O   . ALA C 1 124 ? 1.099   -28.597 46.829  1.00 84.24  ?  118 ALA C O   1 
ATOM   5305 C CB  . ALA C 1 124 ? -0.957  -26.108 47.186  1.00 78.53  ?  118 ALA C CB  1 
ATOM   5306 N N   . HIS C 1 125 ? -0.747  -28.789 45.527  1.00 81.58  ?  119 HIS C N   1 
ATOM   5307 C CA  . HIS C 1 125 ? -0.739  -30.269 45.642  1.00 79.01  ?  119 HIS C CA  1 
ATOM   5308 C C   . HIS C 1 125 ? -0.216  -30.902 44.354  1.00 78.83  ?  119 HIS C C   1 
ATOM   5309 O O   . HIS C 1 125 ? -0.629  -32.028 44.032  1.00 82.73  ?  119 HIS C O   1 
ATOM   5310 C CB  . HIS C 1 125 ? -2.137  -30.739 46.041  1.00 78.85  ?  119 HIS C CB  1 
ATOM   5311 C CG  . HIS C 1 125 ? -2.691  -29.927 47.160  1.00 86.94  ?  119 HIS C CG  1 
ATOM   5312 N ND1 . HIS C 1 125 ? -3.515  -28.841 46.965  1.00 89.61  ?  119 HIS C ND1 1 
ATOM   5313 C CD2 . HIS C 1 125 ? -2.510  -30.023 48.479  1.00 83.70  ?  119 HIS C CD2 1 
ATOM   5314 C CE1 . HIS C 1 125 ? -3.827  -28.316 48.139  1.00 88.61  ?  119 HIS C CE1 1 
ATOM   5315 N NE2 . HIS C 1 125 ? -3.227  -29.019 49.072  1.00 93.39  ?  119 HIS C NE2 1 
ATOM   5316 N N   . GLN C 1 126 ? 0.679   -30.207 43.656  1.00 76.50  ?  120 GLN C N   1 
ATOM   5317 C CA  . GLN C 1 126 ? 1.269   -30.787 42.457  1.00 77.11  ?  120 GLN C CA  1 
ATOM   5318 C C   . GLN C 1 126 ? 0.206   -31.422 41.565  1.00 74.54  ?  120 GLN C C   1 
ATOM   5319 O O   . GLN C 1 126 ? 0.396   -32.510 41.030  1.00 72.57  ?  120 GLN C O   1 
ATOM   5320 C CB  . GLN C 1 126 ? 2.350   -31.809 42.819  1.00 80.48  ?  120 GLN C CB  1 
ATOM   5321 C CG  . GLN C 1 126 ? 3.198   -31.409 44.019  1.00 87.90  ?  120 GLN C CG  1 
ATOM   5322 C CD  . GLN C 1 126 ? 4.669   -31.756 43.843  1.00 100.18 ?  120 GLN C CD  1 
ATOM   5323 O OE1 . GLN C 1 126 ? 5.048   -32.507 42.929  1.00 96.28  ?  120 GLN C OE1 1 
ATOM   5324 N NE2 . GLN C 1 126 ? 5.511   -31.191 44.707  1.00 102.33 ?  120 GLN C NE2 1 
ATOM   5325 N N   . ALA C 1 127 ? -0.929  -30.736 41.402  1.00 73.07  ?  121 ALA C N   1 
ATOM   5326 C CA  . ALA C 1 127 ? -2.034  -31.249 40.602  1.00 76.07  ?  121 ALA C CA  1 
ATOM   5327 C C   . ALA C 1 127 ? -2.340  -30.311 39.438  1.00 74.01  ?  121 ALA C C   1 
ATOM   5328 O O   . ALA C 1 127 ? -2.141  -29.097 39.528  1.00 76.44  ?  121 ALA C O   1 
ATOM   5329 C CB  . ALA C 1 127 ? -3.299  -31.451 41.459  1.00 73.25  ?  121 ALA C CB  1 
ATOM   5330 N N   . VAL C 1 128 ? -2.818  -30.891 38.338  1.00 71.38  ?  122 VAL C N   1 
ATOM   5331 C CA  . VAL C 1 128 ? -3.207  -30.151 37.141  1.00 68.07  ?  122 VAL C CA  1 
ATOM   5332 C C   . VAL C 1 128 ? -4.723  -30.133 37.064  1.00 67.31  ?  122 VAL C C   1 
ATOM   5333 O O   . VAL C 1 128 ? -5.366  -31.174 37.235  1.00 73.58  ?  122 VAL C O   1 
ATOM   5334 C CB  . VAL C 1 128 ? -2.623  -30.786 35.867  1.00 68.50  ?  122 VAL C CB  1 
ATOM   5335 C CG1 . VAL C 1 128 ? -3.238  -30.128 34.636  1.00 65.11  ?  122 VAL C CG1 1 
ATOM   5336 C CG2 . VAL C 1 128 ? -1.116  -30.659 35.842  1.00 64.98  ?  122 VAL C CG2 1 
ATOM   5337 N N   . ALA C 1 129 ? -5.301  -28.971 36.787  1.00 65.50  ?  123 ALA C N   1 
ATOM   5338 C CA  . ALA C 1 129 ? -6.733  -28.883 36.541  1.00 61.35  ?  123 ALA C CA  1 
ATOM   5339 C C   . ALA C 1 129 ? -6.936  -28.199 35.202  1.00 64.63  ?  123 ALA C C   1 
ATOM   5340 O O   . ALA C 1 129 ? -6.414  -27.101 34.984  1.00 63.46  ?  123 ALA C O   1 
ATOM   5341 C CB  . ALA C 1 129 ? -7.450  -28.126 37.653  1.00 59.53  ?  123 ALA C CB  1 
ATOM   5342 N N   . ILE C 1 130 ? -7.664  -28.856 34.298  1.00 61.97  ?  124 ILE C N   1 
ATOM   5343 C CA  . ILE C 1 130 ? -8.091  -28.248 33.041  1.00 60.03  ?  124 ILE C CA  1 
ATOM   5344 C C   . ILE C 1 130 ? -9.590  -28.030 33.128  1.00 59.72  ?  124 ILE C C   1 
ATOM   5345 O O   . ILE C 1 130 ? -10.348 -28.971 33.391  1.00 60.73  ?  124 ILE C O   1 
ATOM   5346 C CB  . ILE C 1 130 ? -7.714  -29.106 31.828  1.00 63.58  ?  124 ILE C CB  1 
ATOM   5347 C CG1 . ILE C 1 130 ? -6.207  -29.392 31.851  1.00 57.26  ?  124 ILE C CG1 1 
ATOM   5348 C CG2 . ILE C 1 130 ? -8.089  -28.371 30.551  1.00 60.57  ?  124 ILE C CG2 1 
ATOM   5349 C CD1 . ILE C 1 130 ? -5.721  -30.134 30.658  1.00 52.37  ?  124 ILE C CD1 1 
ATOM   5350 N N   . LEU C 1 131 ? -10.015 -26.785 32.976  1.00 62.26  ?  125 LEU C N   1 
ATOM   5351 C CA  . LEU C 1 131 ? -11.414 -26.448 33.152  1.00 63.52  ?  125 LEU C CA  1 
ATOM   5352 C C   . LEU C 1 131 ? -12.006 -25.918 31.849  1.00 63.77  ?  125 LEU C C   1 
ATOM   5353 O O   . LEU C 1 131 ? -11.300 -25.399 30.974  1.00 59.33  ?  125 LEU C O   1 
ATOM   5354 C CB  . LEU C 1 131 ? -11.613 -25.400 34.258  1.00 65.17  ?  125 LEU C CB  1 
ATOM   5355 C CG  . LEU C 1 131 ? -11.438 -23.939 33.840  1.00 68.43  ?  125 LEU C CG  1 
ATOM   5356 C CD1 . LEU C 1 131 ? -11.933 -23.011 34.928  1.00 70.05  ?  125 LEU C CD1 1 
ATOM   5357 C CD2 . LEU C 1 131 ? -9.984  -23.653 33.556  1.00 70.18  ?  125 LEU C CD2 1 
ATOM   5358 N N   . ALA C 1 132 ? -13.333 -26.041 31.755  1.00 64.00  ?  126 ALA C N   1 
ATOM   5359 C CA  . ALA C 1 132 ? -14.096 -25.546 30.615  1.00 64.99  ?  126 ALA C CA  1 
ATOM   5360 C C   . ALA C 1 132 ? -13.624 -26.214 29.329  1.00 60.42  ?  126 ALA C C   1 
ATOM   5361 O O   . ALA C 1 132 ? -13.512 -25.582 28.284  1.00 61.70  ?  126 ALA C O   1 
ATOM   5362 C CB  . ALA C 1 132 ? -14.020 -24.018 30.510  1.00 59.07  ?  126 ALA C CB  1 
ATOM   5363 N N   . ALA C 1 133 ? -13.349 -27.511 29.411  1.00 61.92  ?  127 ALA C N   1 
ATOM   5364 C CA  . ALA C 1 133 ? -12.804 -28.271 28.293  1.00 61.44  ?  127 ALA C CA  1 
ATOM   5365 C C   . ALA C 1 133 ? -13.927 -29.107 27.686  1.00 62.21  ?  127 ALA C C   1 
ATOM   5366 O O   . ALA C 1 133 ? -14.008 -30.318 27.867  1.00 59.98  ?  127 ALA C O   1 
ATOM   5367 C CB  . ALA C 1 133 ? -11.636 -29.139 28.764  1.00 62.32  ?  127 ALA C CB  1 
ATOM   5368 N N   . GLY C 1 134 ? -14.798 -28.439 26.945  1.00 61.29  ?  128 GLY C N   1 
ATOM   5369 C CA  . GLY C 1 134 ? -15.966 -29.094 26.390  1.00 60.15  ?  128 GLY C CA  1 
ATOM   5370 C C   . GLY C 1 134 ? -16.130 -28.672 24.951  1.00 63.45  ?  128 GLY C C   1 
ATOM   5371 O O   . GLY C 1 134 ? -15.132 -28.574 24.220  1.00 65.68  ?  128 GLY C O   1 
ATOM   5372 N N   . THR C 1 135 ? -17.362 -28.388 24.532  1.00 63.63  ?  129 THR C N   1 
ATOM   5373 C CA  . THR C 1 135 ? -17.603 -27.964 23.146  1.00 61.04  ?  129 THR C CA  1 
ATOM   5374 C C   . THR C 1 135 ? -17.500 -26.444 23.003  1.00 60.94  ?  129 THR C C   1 
ATOM   5375 O O   . THR C 1 135 ? -16.568 -25.945 22.362  1.00 61.49  ?  129 THR C O   1 
ATOM   5376 C CB  . THR C 1 135 ? -18.938 -28.517 22.651  1.00 59.30  ?  129 THR C CB  1 
ATOM   5377 O OG1 . THR C 1 135 ? -18.878 -29.951 22.717  1.00 60.50  ?  129 THR C OG1 1 
ATOM   5378 C CG2 . THR C 1 135 ? -19.131 -28.156 21.224  1.00 62.90  ?  129 THR C CG2 1 
ATOM   5379 N N   . ASP C 1 136 ? -18.444 -25.668 23.592  1.00 62.90  ?  130 ASP C N   1 
ATOM   5380 C CA  . ASP C 1 136 ? -18.155 -24.271 23.268  1.00 63.19  ?  130 ASP C CA  1 
ATOM   5381 C C   . ASP C 1 136 ? -17.323 -23.606 24.346  1.00 78.60  ?  130 ASP C C   1 
ATOM   5382 O O   . ASP C 1 136 ? -16.380 -22.871 24.009  1.00 79.87  ?  130 ASP C O   1 
ATOM   5383 C CB  . ASP C 1 136 ? -19.333 -23.371 22.999  1.00 60.51  ?  130 ASP C CB  1 
ATOM   5384 C CG  . ASP C 1 136 ? -18.860 -21.960 22.533  1.00 69.47  ?  130 ASP C CG  1 
ATOM   5385 O OD1 . ASP C 1 136 ? -18.216 -21.248 23.338  1.00 62.95  ?  130 ASP C OD1 1 
ATOM   5386 O OD2 . ASP C 1 136 ? -19.087 -21.568 21.356  1.00 71.10  ?  130 ASP C OD2 1 
ATOM   5387 N N   . PRO C 1 137 ? -17.604 -23.784 25.615  1.00 75.04  ?  131 PRO C N   1 
ATOM   5388 C CA  . PRO C 1 137 ? -16.494 -23.618 26.561  1.00 67.55  ?  131 PRO C CA  1 
ATOM   5389 C C   . PRO C 1 137 ? -15.634 -24.823 26.208  1.00 66.05  ?  131 PRO C C   1 
ATOM   5390 O O   . PRO C 1 137 ? -16.027 -25.955 26.504  1.00 72.07  ?  131 PRO C O   1 
ATOM   5391 C CB  . PRO C 1 137 ? -17.154 -23.682 27.946  1.00 64.87  ?  131 PRO C CB  1 
ATOM   5392 C CG  . PRO C 1 137 ? -18.633 -23.518 27.649  1.00 66.73  ?  131 PRO C CG  1 
ATOM   5393 C CD  . PRO C 1 137 ? -18.861 -24.133 26.285  1.00 59.46  ?  131 PRO C CD  1 
ATOM   5394 N N   . GLY C 1 138 ? -14.571 -24.624 25.429  1.00 64.20  ?  132 GLY C N   1 
ATOM   5395 C CA  . GLY C 1 138 ? -13.748 -25.744 24.991  1.00 63.11  ?  132 GLY C CA  1 
ATOM   5396 C C   . GLY C 1 138 ? -13.113 -25.581 23.619  1.00 57.05  ?  132 GLY C C   1 
ATOM   5397 O O   . GLY C 1 138 ? -12.385 -24.608 23.383  1.00 55.58  ?  132 GLY C O   1 
ATOM   5398 N N   . THR C 1 139 ? -13.377 -26.522 22.701  1.00 54.13  ?  133 THR C N   1 
ATOM   5399 C CA  . THR C 1 139 ? -12.703 -26.475 21.403  1.00 58.51  ?  133 THR C CA  1 
ATOM   5400 C C   . THR C 1 139 ? -13.227 -25.332 20.550  1.00 58.35  ?  133 THR C C   1 
ATOM   5401 O O   . THR C 1 139 ? -12.498 -24.816 19.696  1.00 62.12  ?  133 THR C O   1 
ATOM   5402 C CB  . THR C 1 139 ? -12.862 -27.794 20.637  1.00 55.94  ?  133 THR C CB  1 
ATOM   5403 O OG1 . THR C 1 139 ? -14.222 -28.205 20.701  1.00 51.06  ?  133 THR C OG1 1 
ATOM   5404 C CG2 . THR C 1 139 ? -11.979 -28.899 21.257  1.00 53.96  ?  133 THR C CG2 1 
ATOM   5405 N N   . CYS C 1 140 ? -14.475 -24.914 20.752  1.00 51.97  ?  134 CYS C N   1 
ATOM   5406 C CA  . CYS C 1 140 ? -14.914 -23.712 20.062  1.00 59.96  ?  134 CYS C CA  1 
ATOM   5407 C C   . CYS C 1 140 ? -14.083 -22.515 20.498  1.00 60.25  ?  134 CYS C C   1 
ATOM   5408 O O   . CYS C 1 140 ? -13.758 -21.647 19.674  1.00 59.16  ?  134 CYS C O   1 
ATOM   5409 C CB  . CYS C 1 140 ? -16.417 -23.486 20.278  1.00 56.77  ?  134 CYS C CB  1 
ATOM   5410 S SG  . CYS C 1 140 ? -17.422 -24.625 19.230  1.00 55.82  ?  134 CYS C SG  1 
ATOM   5411 N N   . SER C 1 141 ? -13.685 -22.477 21.776  1.00 57.96  ?  135 SER C N   1 
ATOM   5412 C CA  . SER C 1 141 ? -12.810 -21.400 22.234  1.00 61.02  ?  135 SER C CA  1 
ATOM   5413 C C   . SER C 1 141 ? -11.481 -21.435 21.498  1.00 55.25  ?  135 SER C C   1 
ATOM   5414 O O   . SER C 1 141 ? -10.943 -20.384 21.125  1.00 53.25  ?  135 SER C O   1 
ATOM   5415 C CB  . SER C 1 141 ? -12.570 -21.480 23.742  1.00 58.69  ?  135 SER C CB  1 
ATOM   5416 O OG  . SER C 1 141 ? -13.664 -22.073 24.412  1.00 57.29  ?  135 SER C OG  1 
ATOM   5417 N N   . MET C 1 142 ? -10.969 -22.639 21.230  1.00 53.28  ?  136 MET C N   1 
ATOM   5418 C CA  . MET C 1 142 ? -9.684  -22.748 20.551  1.00 53.37  ?  136 MET C CA  1 
ATOM   5419 C C   . MET C 1 142 ? -9.792  -22.253 19.105  1.00 56.59  ?  136 MET C C   1 
ATOM   5420 O O   . MET C 1 142 ? -8.924  -21.509 18.629  1.00 54.43  ?  136 MET C O   1 
ATOM   5421 C CB  . MET C 1 142 ? -9.173  -24.194 20.586  1.00 55.01  ?  136 MET C CB  1 
ATOM   5422 C CG  . MET C 1 142 ? -8.722  -24.718 21.950  1.00 55.77  ?  136 MET C CG  1 
ATOM   5423 S SD  . MET C 1 142 ? -8.540  -26.544 21.998  1.00 55.76  ?  136 MET C SD  1 
ATOM   5424 C CE  . MET C 1 142 ? -6.796  -26.663 21.560  1.00 50.37  ?  136 MET C CE  1 
ATOM   5425 N N   . ILE C 1 143 ? -10.849 -22.646 18.381  1.00 55.40  ?  137 ILE C N   1 
ATOM   5426 C CA  . ILE C 1 143 ? -11.010 -22.126 17.025  1.00 58.13  ?  137 ILE C CA  1 
ATOM   5427 C C   . ILE C 1 143 ? -11.202 -20.603 17.050  1.00 57.26  ?  137 ILE C C   1 
ATOM   5428 O O   . ILE C 1 143 ? -10.608 -19.876 16.242  1.00 55.54  ?  137 ILE C O   1 
ATOM   5429 C CB  . ILE C 1 143 ? -12.176 -22.824 16.304  1.00 58.92  ?  137 ILE C CB  1 
ATOM   5430 C CG1 . ILE C 1 143 ? -12.047 -24.345 16.372  1.00 57.01  ?  137 ILE C CG1 1 
ATOM   5431 C CG2 . ILE C 1 143 ? -12.248 -22.342 14.857  1.00 54.86  ?  137 ILE C CG2 1 
ATOM   5432 C CD1 . ILE C 1 143 ? -10.818 -24.851 15.712  1.00 59.63  ?  137 ILE C CD1 1 
ATOM   5433 N N   . ARG C 1 144 ? -12.040 -20.098 17.961  1.00 53.42  ?  138 ARG C N   1 
ATOM   5434 C CA  . ARG C 1 144 ? -12.204 -18.651 18.084  1.00 52.60  ?  138 ARG C CA  1 
ATOM   5435 C C   . ARG C 1 144 ? -10.852 -17.972 18.253  1.00 56.61  ?  138 ARG C C   1 
ATOM   5436 O O   . ARG C 1 144 ? -10.487 -17.067 17.491  1.00 51.37  ?  138 ARG C O   1 
ATOM   5437 C CB  . ARG C 1 144 ? -13.101 -18.320 19.271  1.00 49.27  ?  138 ARG C CB  1 
ATOM   5438 C CG  . ARG C 1 144 ? -14.548 -18.156 18.907  1.00 55.92  ?  138 ARG C CG  1 
ATOM   5439 C CD  . ARG C 1 144 ? -15.305 -17.376 19.964  1.00 55.99  ?  138 ARG C CD  1 
ATOM   5440 N NE  . ARG C 1 144 ? -15.329 -18.021 21.271  1.00 56.46  ?  138 ARG C NE  1 
ATOM   5441 C CZ  . ARG C 1 144 ? -16.178 -18.977 21.623  1.00 61.72  ?  138 ARG C CZ  1 
ATOM   5442 N NH1 . ARG C 1 144 ? -17.095 -19.429 20.781  1.00 64.44  ?  138 ARG C NH1 1 
ATOM   5443 N NH2 . ARG C 1 144 ? -16.103 -19.499 22.851  1.00 55.26  ?  138 ARG C NH2 1 
ATOM   5444 N N   . SER C 1 145 ? -10.080 -18.429 19.240  1.00 53.99  ?  139 SER C N   1 
ATOM   5445 C CA  . SER C 1 145 ? -8.806  -17.796 19.533  1.00 50.59  ?  139 SER C CA  1 
ATOM   5446 C C   . SER C 1 145 ? -7.884  -17.803 18.323  1.00 50.80  ?  139 SER C C   1 
ATOM   5447 O O   . SER C 1 145 ? -7.132  -16.847 18.115  1.00 55.07  ?  139 SER C O   1 
ATOM   5448 C CB  . SER C 1 145 ? -8.155  -18.491 20.727  1.00 52.84  ?  139 SER C CB  1 
ATOM   5449 O OG  . SER C 1 145 ? -8.994  -18.421 21.874  1.00 50.16  ?  139 SER C OG  1 
ATOM   5450 N N   . ILE C 1 146 ? -7.936  -18.845 17.495  1.00 52.02  ?  140 ILE C N   1 
ATOM   5451 C CA  . ILE C 1 146 ? -7.036  -18.898 16.346  1.00 49.74  ?  140 ILE C CA  1 
ATOM   5452 C C   . ILE C 1 146 ? -7.509  -17.943 15.248  1.00 54.85  ?  140 ILE C C   1 
ATOM   5453 O O   . ILE C 1 146 ? -6.705  -17.193 14.665  1.00 51.82  ?  140 ILE C O   1 
ATOM   5454 C CB  . ILE C 1 146 ? -6.907  -20.348 15.858  1.00 51.38  ?  140 ILE C CB  1 
ATOM   5455 C CG1 . ILE C 1 146 ? -6.127  -21.189 16.881  1.00 50.99  ?  140 ILE C CG1 1 
ATOM   5456 C CG2 . ILE C 1 146 ? -6.238  -20.419 14.482  1.00 53.01  ?  140 ILE C CG2 1 
ATOM   5457 C CD1 . ILE C 1 146 ? -6.231  -22.713 16.625  1.00 57.42  ?  140 ILE C CD1 1 
ATOM   5458 N N   . LEU C 1 147 ? -8.819  -17.924 14.978  1.00 53.72  ?  141 LEU C N   1 
ATOM   5459 C CA  . LEU C 1 147 ? -9.367  -16.884 14.115  1.00 55.05  ?  141 LEU C CA  1 
ATOM   5460 C C   . LEU C 1 147 ? -8.929  -15.499 14.589  1.00 52.43  ?  141 LEU C C   1 
ATOM   5461 O O   . LEU C 1 147 ? -8.575  -14.635 13.765  1.00 49.42  ?  141 LEU C O   1 
ATOM   5462 C CB  . LEU C 1 147 ? -10.896 -16.981 14.055  1.00 46.62  ?  141 LEU C CB  1 
ATOM   5463 C CG  . LEU C 1 147 ? -11.530 -18.321 13.679  1.00 53.34  ?  141 LEU C CG  1 
ATOM   5464 C CD1 . LEU C 1 147 ? -13.056 -18.257 13.635  1.00 50.83  ?  141 LEU C CD1 1 
ATOM   5465 C CD2 . LEU C 1 147 ? -10.993 -18.838 12.378  1.00 53.01  ?  141 LEU C CD2 1 
ATOM   5466 N N   . GLU C 1 148 ? -8.897  -15.285 15.916  1.00 44.75  ?  142 GLU C N   1 
ATOM   5467 C CA  . GLU C 1 148 ? -8.595  -13.950 16.434  1.00 55.89  ?  142 GLU C CA  1 
ATOM   5468 C C   . GLU C 1 148 ? -7.233  -13.468 15.960  1.00 55.74  ?  142 GLU C C   1 
ATOM   5469 O O   . GLU C 1 148 ? -7.111  -12.347 15.464  1.00 57.44  ?  142 GLU C O   1 
ATOM   5470 C CB  . GLU C 1 148 ? -8.648  -13.915 17.958  1.00 54.32  ?  142 GLU C CB  1 
ATOM   5471 C CG  . GLU C 1 148 ? -9.963  -13.435 18.470  1.00 66.96  ?  142 GLU C CG  1 
ATOM   5472 C CD  . GLU C 1 148 ? -10.065 -11.940 18.584  1.00 68.54  ?  142 GLU C CD  1 
ATOM   5473 O OE1 . GLU C 1 148 ? -9.356  -11.360 19.431  1.00 76.30  ?  142 GLU C OE1 1 
ATOM   5474 O OE2 . GLU C 1 148 ? -10.882 -11.345 17.850  1.00 71.87  -1 142 GLU C OE2 1 
ATOM   5475 N N   . PHE C 1 149 ? -6.195  -14.306 16.088  1.00 52.61  ?  143 PHE C N   1 
ATOM   5476 C CA  . PHE C 1 149 ? -4.874  -13.831 15.721  1.00 48.90  ?  143 PHE C CA  1 
ATOM   5477 C C   . PHE C 1 149 ? -4.611  -13.914 14.225  1.00 50.04  ?  143 PHE C C   1 
ATOM   5478 O O   . PHE C 1 149 ? -3.707  -13.234 13.750  1.00 55.17  ?  143 PHE C O   1 
ATOM   5479 C CB  . PHE C 1 149 ? -3.776  -14.545 16.555  1.00 50.04  ?  143 PHE C CB  1 
ATOM   5480 C CG  . PHE C 1 149 ? -3.415  -15.970 16.117  1.00 50.87  ?  143 PHE C CG  1 
ATOM   5481 C CD1 . PHE C 1 149 ? -2.622  -16.207 14.991  1.00 45.94  ?  143 PHE C CD1 1 
ATOM   5482 C CD2 . PHE C 1 149 ? -3.803  -17.067 16.897  1.00 48.05  ?  143 PHE C CD2 1 
ATOM   5483 C CE1 . PHE C 1 149 ? -2.276  -17.512 14.609  1.00 44.09  ?  143 PHE C CE1 1 
ATOM   5484 C CE2 . PHE C 1 149 ? -3.463  -18.359 16.521  1.00 48.80  ?  143 PHE C CE2 1 
ATOM   5485 C CZ  . PHE C 1 149 ? -2.688  -18.581 15.376  1.00 47.67  ?  143 PHE C CZ  1 
ATOM   5486 N N   . MET C 1 150 ? -5.381  -14.691 13.449  1.00 52.93  ?  144 MET C N   1 
ATOM   5487 C CA  . MET C 1 150 ? -5.204  -14.609 11.998  1.00 49.61  ?  144 MET C CA  1 
ATOM   5488 C C   . MET C 1 150 ? -5.825  -13.341 11.403  1.00 56.77  ?  144 MET C C   1 
ATOM   5489 O O   . MET C 1 150 ? -5.427  -12.912 10.310  1.00 52.53  ?  144 MET C O   1 
ATOM   5490 C CB  . MET C 1 150 ? -5.830  -15.794 11.278  1.00 49.88  ?  144 MET C CB  1 
ATOM   5491 C CG  . MET C 1 150 ? -5.563  -17.164 11.829  1.00 51.56  ?  144 MET C CG  1 
ATOM   5492 S SD  . MET C 1 150 ? -6.196  -18.370 10.635  1.00 55.15  ?  144 MET C SD  1 
ATOM   5493 C CE  . MET C 1 150 ? -7.621  -18.872 11.588  1.00 56.93  ?  144 MET C CE  1 
ATOM   5494 N N   . ALA C 1 151 ? -6.816  -12.747 12.067  1.00 55.83  ?  145 ALA C N   1 
ATOM   5495 C CA  . ALA C 1 151 ? -7.493  -11.561 11.543  1.00 56.81  ?  145 ALA C CA  1 
ATOM   5496 C C   . ALA C 1 151 ? -7.919  -10.691 12.711  1.00 57.66  ?  145 ALA C C   1 
ATOM   5497 O O   . ALA C 1 151 ? -9.071  -10.744 13.168  1.00 55.21  ?  145 ALA C O   1 
ATOM   5498 C CB  . ALA C 1 151 ? -8.682  -11.949 10.665  1.00 53.90  ?  145 ALA C CB  1 
ATOM   5499 N N   . PRO C 1 152 ? -6.996  -9.870  13.231  1.00 53.88  ?  146 PRO C N   1 
ATOM   5500 C CA  . PRO C 1 152 ? -7.229  -9.212  14.525  1.00 48.03  ?  146 PRO C CA  1 
ATOM   5501 C C   . PRO C 1 152 ? -8.302  -8.153  14.498  1.00 55.31  ?  146 PRO C C   1 
ATOM   5502 O O   . PRO C 1 152 ? -8.856  -7.820  15.557  1.00 59.41  ?  146 PRO C O   1 
ATOM   5503 C CB  . PRO C 1 152 ? -5.858  -8.610  14.862  1.00 51.84  ?  146 PRO C CB  1 
ATOM   5504 C CG  . PRO C 1 152 ? -4.876  -9.458  14.111  1.00 49.27  ?  146 PRO C CG  1 
ATOM   5505 C CD  . PRO C 1 152 ? -5.582  -9.831  12.829  1.00 50.58  ?  146 PRO C CD  1 
ATOM   5506 N N   . TYR C 1 153 ? -8.609  -7.582  13.346  1.00 60.91  ?  147 TYR C N   1 
ATOM   5507 C CA  . TYR C 1 153 ? -9.715  -6.642  13.247  1.00 58.10  ?  147 TYR C CA  1 
ATOM   5508 C C   . TYR C 1 153 ? -10.889 -7.367  12.628  1.00 60.22  ?  147 TYR C C   1 
ATOM   5509 O O   . TYR C 1 153 ? -10.728 -8.093  11.645  1.00 59.48  ?  147 TYR C O   1 
ATOM   5510 C CB  . TYR C 1 153 ? -9.369  -5.423  12.394  1.00 61.90  ?  147 TYR C CB  1 
ATOM   5511 C CG  . TYR C 1 153 ? -8.235  -4.592  12.912  1.00 61.71  ?  147 TYR C CG  1 
ATOM   5512 C CD1 . TYR C 1 153 ? -8.423  -3.709  13.959  1.00 64.93  ?  147 TYR C CD1 1 
ATOM   5513 C CD2 . TYR C 1 153 ? -6.978  -4.688  12.356  1.00 62.28  ?  147 TYR C CD2 1 
ATOM   5514 C CE1 . TYR C 1 153 ? -7.385  -2.943  14.439  1.00 65.69  ?  147 TYR C CE1 1 
ATOM   5515 C CE2 . TYR C 1 153 ? -5.936  -3.920  12.824  1.00 63.46  ?  147 TYR C CE2 1 
ATOM   5516 C CZ  . TYR C 1 153 ? -6.147  -3.054  13.865  1.00 65.26  ?  147 TYR C CZ  1 
ATOM   5517 O OH  . TYR C 1 153 ? -5.109  -2.297  14.339  1.00 70.86  ?  147 TYR C OH  1 
ATOM   5518 N N   . GLY C 1 154 ? -12.056 -7.171  13.200  1.00 63.00  ?  148 GLY C N   1 
ATOM   5519 C CA  . GLY C 1 154 ? -13.254 -7.761  12.667  1.00 57.53  ?  148 GLY C CA  1 
ATOM   5520 C C   . GLY C 1 154 ? -14.110 -8.252  13.795  1.00 58.08  ?  148 GLY C C   1 
ATOM   5521 O O   . GLY C 1 154 ? -13.931 -7.841  14.948  1.00 53.13  ?  148 GLY C O   1 
ATOM   5522 N N   . ILE C 1 155 ? -15.042 -9.138  13.432  1.00 53.37  ?  149 ILE C N   1 
ATOM   5523 C CA  . ILE C 1 155 ? -16.049 -9.641  14.353  1.00 50.67  ?  149 ILE C CA  1 
ATOM   5524 C C   . ILE C 1 155 ? -16.216 -11.128 14.124  1.00 56.27  ?  149 ILE C C   1 
ATOM   5525 O O   . ILE C 1 155 ? -16.275 -11.599 12.979  1.00 55.86  ?  149 ILE C O   1 
ATOM   5526 C CB  . ILE C 1 155 ? -17.419 -8.941  14.194  1.00 53.39  ?  149 ILE C CB  1 
ATOM   5527 C CG1 . ILE C 1 155 ? -17.297 -7.413  14.137  1.00 56.35  ?  149 ILE C CG1 1 
ATOM   5528 C CG2 . ILE C 1 155 ? -18.348 -9.322  15.344  1.00 56.15  ?  149 ILE C CG2 1 
ATOM   5529 C CD1 . ILE C 1 155 ? -18.587 -6.734  13.653  1.00 52.55  ?  149 ILE C CD1 1 
ATOM   5530 N N   . THR C 1 156 ? -16.318 -11.864 15.220  1.00 55.26  ?  150 THR C N   1 
ATOM   5531 C CA  . THR C 1 156 ? -16.630 -13.274 15.174  1.00 53.46  ?  150 THR C CA  1 
ATOM   5532 C C   . THR C 1 156 ? -18.064 -13.485 15.636  1.00 57.73  ?  150 THR C C   1 
ATOM   5533 O O   . THR C 1 156 ? -18.504 -12.887 16.624  1.00 56.58  ?  150 THR C O   1 
ATOM   5534 C CB  . THR C 1 156 ? -15.659 -14.067 16.039  1.00 48.60  ?  150 THR C CB  1 
ATOM   5535 O OG1 . THR C 1 156 ? -14.358 -13.967 15.457  1.00 54.91  ?  150 THR C OG1 1 
ATOM   5536 C CG2 . THR C 1 156 ? -16.081 -15.556 16.092  1.00 51.34  ?  150 THR C CG2 1 
ATOM   5537 N N   . TYR C 1 157 ? -18.795 -14.322 14.909  1.00 57.74  ?  151 TYR C N   1 
ATOM   5538 C CA  . TYR C 1 157 ? -20.113 -14.761 15.339  1.00 60.83  ?  151 TYR C CA  1 
ATOM   5539 C C   . TYR C 1 157 ? -20.097 -16.264 15.560  1.00 61.06  ?  151 TYR C C   1 
ATOM   5540 O O   . TYR C 1 157 ? -19.655 -17.023 14.689  1.00 56.09  ?  151 TYR C O   1 
ATOM   5541 C CB  . TYR C 1 157 ? -21.172 -14.392 14.314  1.00 58.18  ?  151 TYR C CB  1 
ATOM   5542 C CG  . TYR C 1 157 ? -21.313 -12.909 14.140  1.00 60.13  ?  151 TYR C CG  1 
ATOM   5543 C CD1 . TYR C 1 157 ? -21.665 -12.100 15.219  1.00 60.28  ?  151 TYR C CD1 1 
ATOM   5544 C CD2 . TYR C 1 157 ? -21.109 -12.316 12.898  1.00 56.03  ?  151 TYR C CD2 1 
ATOM   5545 C CE1 . TYR C 1 157 ? -21.810 -10.728 15.062  1.00 64.67  ?  151 TYR C CE1 1 
ATOM   5546 C CE2 . TYR C 1 157 ? -21.245 -10.968 12.726  1.00 58.73  ?  151 TYR C CE2 1 
ATOM   5547 C CZ  . TYR C 1 157 ? -21.590 -10.168 13.810  1.00 65.30  ?  151 TYR C CZ  1 
ATOM   5548 O OH  . TYR C 1 157 ? -21.732 -8.810  13.635  1.00 64.08  ?  151 TYR C OH  1 
ATOM   5549 N N   . THR C 1 158 ? -20.579 -16.685 16.722  1.00 60.99  ?  152 THR C N   1 
ATOM   5550 C CA  . THR C 1 158 ? -20.752 -18.092 17.043  1.00 62.38  ?  152 THR C CA  1 
ATOM   5551 C C   . THR C 1 158 ? -22.253 -18.350 17.056  1.00 62.51  ?  152 THR C C   1 
ATOM   5552 O O   . THR C 1 158 ? -22.963 -17.873 17.946  1.00 62.26  ?  152 THR C O   1 
ATOM   5553 C CB  . THR C 1 158 ? -20.094 -18.430 18.380  1.00 64.22  ?  152 THR C CB  1 
ATOM   5554 O OG1 . THR C 1 158 ? -18.751 -17.929 18.371  1.00 73.01  ?  152 THR C OG1 1 
ATOM   5555 C CG2 . THR C 1 158 ? -20.067 -19.933 18.617  1.00 62.63  ?  152 THR C CG2 1 
ATOM   5556 N N   . ASN C 1 159 ? -22.732 -19.067 16.048  1.00 62.48  ?  153 ASN C N   1 
ATOM   5557 C CA  . ASN C 1 159 ? -24.156 -19.318 15.830  1.00 65.45  ?  153 ASN C CA  1 
ATOM   5558 C C   . ASN C 1 159 ? -24.425 -20.779 16.152  1.00 66.26  ?  153 ASN C C   1 
ATOM   5559 O O   . ASN C 1 159 ? -23.996 -21.661 15.401  1.00 63.59  ?  153 ASN C O   1 
ATOM   5560 C CB  . ASN C 1 159 ? -24.536 -19.005 14.387  1.00 57.79  ?  153 ASN C CB  1 
ATOM   5561 C CG  . ASN C 1 159 ? -24.195 -17.570 13.988  1.00 64.96  ?  153 ASN C CG  1 
ATOM   5562 O OD1 . ASN C 1 159 ? -24.906 -16.634 14.350  1.00 67.74  ?  153 ASN C OD1 1 
ATOM   5563 N ND2 . ASN C 1 159 ? -23.112 -17.398 13.228  1.00 63.01  ?  153 ASN C ND2 1 
ATOM   5564 N N   . VAL C 1 160 ? -25.100 -21.044 17.271  1.00 69.10  ?  154 VAL C N   1 
ATOM   5565 C CA  . VAL C 1 160 ? -25.376 -22.430 17.656  1.00 72.99  ?  154 VAL C CA  1 
ATOM   5566 C C   . VAL C 1 160 ? -26.623 -22.884 16.899  1.00 80.94  ?  154 VAL C C   1 
ATOM   5567 O O   . VAL C 1 160 ? -27.752 -22.521 17.251  1.00 81.22  ?  154 VAL C O   1 
ATOM   5568 C CB  . VAL C 1 160 ? -25.533 -22.610 19.167  1.00 71.55  ?  154 VAL C CB  1 
ATOM   5569 C CG1 . VAL C 1 160 ? -26.419 -21.562 19.755  1.00 83.64  ?  154 VAL C CG1 1 
ATOM   5570 C CG2 . VAL C 1 160 ? -26.126 -23.963 19.437  1.00 75.98  ?  154 VAL C CG2 1 
ATOM   5571 N N   . GLY C 1 161 ? -26.402 -23.672 15.830  1.00 83.51  ?  155 GLY C N   1 
ATOM   5572 C CA  . GLY C 1 161 ? -27.438 -24.242 14.989  1.00 80.88  ?  155 GLY C CA  1 
ATOM   5573 C C   . GLY C 1 161 ? -28.485 -24.973 15.801  1.00 82.58  ?  155 GLY C C   1 
ATOM   5574 O O   . GLY C 1 161 ? -28.256 -25.297 16.980  1.00 78.59  ?  155 GLY C O   1 
ATOM   5575 N N   . PRO C 1 162 ? -29.656 -25.234 15.197  1.00 85.84  ?  156 PRO C N   1 
ATOM   5576 C CA  . PRO C 1 162 ? -30.794 -25.723 15.989  1.00 83.77  ?  156 PRO C CA  1 
ATOM   5577 C C   . PRO C 1 162 ? -30.410 -26.947 16.808  1.00 78.54  ?  156 PRO C C   1 
ATOM   5578 O O   . PRO C 1 162 ? -29.771 -27.885 16.327  1.00 73.78  ?  156 PRO C O   1 
ATOM   5579 C CB  . PRO C 1 162 ? -31.887 -26.013 14.946  1.00 70.50  ?  156 PRO C CB  1 
ATOM   5580 C CG  . PRO C 1 162 ? -31.364 -25.584 13.650  1.00 75.65  ?  156 PRO C CG  1 
ATOM   5581 C CD  . PRO C 1 162 ? -30.030 -24.939 13.803  1.00 81.76  ?  156 PRO C CD  1 
ATOM   5582 N N   . GLY C 1 163 ? -30.739 -26.880 18.081  1.00 77.16  ?  157 GLY C N   1 
ATOM   5583 C CA  . GLY C 1 163 ? -30.238 -27.832 19.022  1.00 76.84  ?  157 GLY C CA  1 
ATOM   5584 C C   . GLY C 1 163 ? -30.625 -27.354 20.393  1.00 83.42  ?  157 GLY C C   1 
ATOM   5585 O O   . GLY C 1 163 ? -30.809 -26.155 20.619  1.00 83.45  ?  157 GLY C O   1 
ATOM   5586 N N   . MET C 1 164 ? -30.737 -28.305 21.312  1.00 92.93  ?  158 MET C N   1 
ATOM   5587 C CA  . MET C 1 164 ? -31.287 -28.053 22.631  1.00 98.28  ?  158 MET C CA  1 
ATOM   5588 C C   . MET C 1 164 ? -30.470 -27.003 23.377  1.00 92.39  ?  158 MET C C   1 
ATOM   5589 O O   . MET C 1 164 ? -29.337 -26.675 23.015  1.00 96.37  ?  158 MET C O   1 
ATOM   5590 C CB  . MET C 1 164 ? -31.331 -29.355 23.428  1.00 93.95  ?  158 MET C CB  1 
ATOM   5591 C CG  . MET C 1 164 ? -32.536 -29.503 24.323  1.00 96.38  ?  158 MET C CG  1 
ATOM   5592 S SD  . MET C 1 164 ? -32.570 -31.193 24.921  1.00 98.45  ?  158 MET C SD  1 
ATOM   5593 C CE  . MET C 1 164 ? -32.452 -32.039 23.352  1.00 84.15  ?  158 MET C CE  1 
ATOM   5594 N N   . SER C 1 165 ? -31.087 -26.452 24.415  1.00 90.14  ?  159 SER C N   1 
ATOM   5595 C CA  . SER C 1 165 ? -30.398 -25.642 25.411  1.00 99.52  ?  159 SER C CA  1 
ATOM   5596 C C   . SER C 1 165 ? -30.812 -26.230 26.754  1.00 102.27 ?  159 SER C C   1 
ATOM   5597 O O   . SER C 1 165 ? -31.904 -25.936 27.247  1.00 103.73 ?  159 SER C O   1 
ATOM   5598 C CB  . SER C 1 165 ? -30.762 -24.166 25.288  1.00 104.05 ?  159 SER C CB  1 
ATOM   5599 O OG  . SER C 1 165 ? -29.923 -23.359 26.098  1.00 105.52 ?  159 SER C OG  1 
ATOM   5600 N N   . MET C 1 166 ? -29.947 -27.080 27.317  1.00 106.48 ?  160 MET C N   1 
ATOM   5601 C CA  . MET C 1 166 ? -30.260 -27.777 28.564  1.00 110.32 ?  160 MET C CA  1 
ATOM   5602 C C   . MET C 1 166 ? -30.765 -26.815 29.632  1.00 112.70 ?  160 MET C C   1 
ATOM   5603 O O   . MET C 1 166 ? -31.833 -27.023 30.221  1.00 113.70 ?  160 MET C O   1 
ATOM   5604 C CB  . MET C 1 166 ? -29.026 -28.535 29.061  1.00 108.78 ?  160 MET C CB  1 
ATOM   5605 C CG  . MET C 1 166 ? -29.340 -29.779 29.879  1.00 109.04 ?  160 MET C CG  1 
ATOM   5606 S SD  . MET C 1 166 ? -30.537 -30.858 29.059  1.00 124.34 ?  160 MET C SD  1 
ATOM   5607 C CE  . MET C 1 166 ? -30.012 -32.477 29.640  1.00 109.31 ?  160 MET C CE  1 
ATOM   5608 N N   . GLY C 1 167 ? -30.013 -25.746 29.889  1.00 109.50 ?  161 GLY C N   1 
ATOM   5609 C CA  . GLY C 1 167 ? -30.446 -24.791 30.889  1.00 110.96 ?  161 GLY C CA  1 
ATOM   5610 C C   . GLY C 1 167 ? -31.795 -24.181 30.567  1.00 108.96 ?  161 GLY C C   1 
ATOM   5611 O O   . GLY C 1 167 ? -32.624 -23.985 31.459  1.00 111.13 ?  161 GLY C O   1 
ATOM   5612 N N   . HIS C 1 168 ? -32.038 -23.885 29.287  1.00 106.99 ?  162 HIS C N   1 
ATOM   5613 C CA  . HIS C 1 168 ? -33.251 -23.160 28.912  1.00 113.01 ?  162 HIS C CA  1 
ATOM   5614 C C   . HIS C 1 168 ? -34.498 -24.003 29.154  1.00 113.95 ?  162 HIS C C   1 
ATOM   5615 O O   . HIS C 1 168 ? -35.495 -23.510 29.699  1.00 113.12 ?  162 HIS C O   1 
ATOM   5616 C CB  . HIS C 1 168 ? -33.180 -22.715 27.448  1.00 109.02 ?  162 HIS C CB  1 
ATOM   5617 C CG  . HIS C 1 168 ? -32.328 -21.504 27.221  1.00 113.76 ?  162 HIS C CG  1 
ATOM   5618 N ND1 . HIS C 1 168 ? -30.965 -21.501 27.427  1.00 111.84 ?  162 HIS C ND1 1 
ATOM   5619 C CD2 . HIS C 1 168 ? -32.651 -20.250 26.820  1.00 109.09 ?  162 HIS C CD2 1 
ATOM   5620 C CE1 . HIS C 1 168 ? -30.484 -20.301 27.151  1.00 110.16 ?  162 HIS C CE1 1 
ATOM   5621 N NE2 . HIS C 1 168 ? -31.487 -19.524 26.780  1.00 108.50 ?  162 HIS C NE2 1 
ATOM   5622 N N   . SER C 1 169 ? -34.467 -25.275 28.739  1.00 112.51 ?  163 SER C N   1 
ATOM   5623 C CA  . SER C 1 169 ? -35.595 -26.162 29.009  1.00 111.44 ?  163 SER C CA  1 
ATOM   5624 C C   . SER C 1 169 ? -35.728 -26.429 30.504  1.00 115.46 ?  163 SER C C   1 
ATOM   5625 O O   . SER C 1 169 ? -36.840 -26.403 31.051  1.00 113.70 ?  163 SER C O   1 
ATOM   5626 C CB  . SER C 1 169 ? -35.445 -27.469 28.222  1.00 102.90 ?  163 SER C CB  1 
ATOM   5627 O OG  . SER C 1 169 ? -34.360 -28.253 28.690  1.00 108.14 ?  163 SER C OG  1 
ATOM   5628 N N   . VAL C 1 170 ? -34.596 -26.666 31.182  1.00 118.24 ?  164 VAL C N   1 
ATOM   5629 C CA  . VAL C 1 170 ? -34.595 -26.808 32.638  1.00 118.69 ?  164 VAL C CA  1 
ATOM   5630 C C   . VAL C 1 170 ? -35.159 -25.548 33.293  1.00 117.93 ?  164 VAL C C   1 
ATOM   5631 O O   . VAL C 1 170 ? -35.866 -25.619 34.308  1.00 118.22 ?  164 VAL C O   1 
ATOM   5632 C CB  . VAL C 1 170 ? -33.173 -27.148 33.135  1.00 114.00 ?  164 VAL C CB  1 
ATOM   5633 C CG1 . VAL C 1 170 ? -33.024 -26.862 34.618  1.00 117.58 ?  164 VAL C CG1 1 
ATOM   5634 C CG2 . VAL C 1 170 ? -32.836 -28.609 32.841  1.00 108.88 ?  164 VAL C CG2 1 
ATOM   5635 N N   . ALA C 1 171 ? -34.888 -24.379 32.706  1.00 114.46 ?  165 ALA C N   1 
ATOM   5636 C CA  . ALA C 1 171 ? -35.556 -23.160 33.146  1.00 115.53 ?  165 ALA C CA  1 
ATOM   5637 C C   . ALA C 1 171 ? -37.073 -23.314 33.058  1.00 121.12 ?  165 ALA C C   1 
ATOM   5638 O O   . ALA C 1 171 ? -37.780 -23.228 34.070  1.00 121.61 ?  165 ALA C O   1 
ATOM   5639 C CB  . ALA C 1 171 ? -35.076 -21.962 32.318  1.00 108.12 ?  165 ALA C CB  1 
ATOM   5640 N N   . VAL C 1 172 ? -37.590 -23.577 31.852  1.00 119.99 ?  166 VAL C N   1 
ATOM   5641 C CA  . VAL C 1 172 ? -39.038 -23.638 31.659  1.00 123.65 ?  166 VAL C CA  1 
ATOM   5642 C C   . VAL C 1 172 ? -39.665 -24.787 32.439  1.00 123.82 ?  166 VAL C C   1 
ATOM   5643 O O   . VAL C 1 172 ? -40.855 -24.726 32.782  1.00 121.52 ?  166 VAL C O   1 
ATOM   5644 C CB  . VAL C 1 172 ? -39.386 -23.729 30.156  1.00 118.37 ?  166 VAL C CB  1 
ATOM   5645 C CG1 . VAL C 1 172 ? -40.891 -23.497 29.927  1.00 108.25 ?  166 VAL C CG1 1 
ATOM   5646 C CG2 . VAL C 1 172 ? -38.557 -22.727 29.366  1.00 113.74 ?  166 VAL C CG2 1 
ATOM   5647 N N   . LYS C 1 173 ? -38.883 -25.827 32.754  1.00 120.77 ?  167 LYS C N   1 
ATOM   5648 C CA  . LYS C 1 173 ? -39.374 -26.915 33.592  1.00 123.09 ?  167 LYS C CA  1 
ATOM   5649 C C   . LYS C 1 173 ? -39.769 -26.447 34.987  1.00 125.37 ?  167 LYS C C   1 
ATOM   5650 O O   . LYS C 1 173 ? -40.378 -27.224 35.731  1.00 126.58 ?  167 LYS C O   1 
ATOM   5651 C CB  . LYS C 1 173 ? -38.319 -28.027 33.712  1.00 119.90 ?  167 LYS C CB  1 
ATOM   5652 C CG  . LYS C 1 173 ? -38.380 -29.116 32.635  1.00 115.14 ?  167 LYS C CG  1 
ATOM   5653 C CD  . LYS C 1 173 ? -37.100 -29.954 32.620  1.00 109.33 ?  167 LYS C CD  1 
ATOM   5654 C CE  . LYS C 1 173 ? -37.364 -31.400 32.220  1.00 103.48 ?  167 LYS C CE  1 
ATOM   5655 N NZ  . LYS C 1 173 ? -38.633 -31.554 31.452  1.00 98.02  ?  167 LYS C NZ  1 
ATOM   5656 N N   . ALA C 1 174 ? -39.447 -25.207 35.361  1.00 123.79 ?  168 ALA C N   1 
ATOM   5657 C CA  . ALA C 1 174 ? -39.707 -24.702 36.703  1.00 127.47 ?  168 ALA C CA  1 
ATOM   5658 C C   . ALA C 1 174 ? -40.797 -23.628 36.730  1.00 129.26 ?  168 ALA C C   1 
ATOM   5659 O O   . ALA C 1 174 ? -40.729 -22.690 37.528  1.00 128.86 ?  168 ALA C O   1 
ATOM   5660 C CB  . ALA C 1 174 ? -38.416 -24.170 37.325  1.00 125.28 ?  168 ALA C CB  1 
ATOM   5661 N N   . ILE C 1 175 ? -41.809 -23.751 35.868  1.00 129.53 ?  169 ILE C N   1 
ATOM   5662 C CA  . ILE C 1 175 ? -42.957 -22.851 35.864  1.00 129.08 ?  169 ILE C CA  1 
ATOM   5663 C C   . ILE C 1 175 ? -44.217 -23.709 35.887  1.00 128.82 ?  169 ILE C C   1 
ATOM   5664 O O   . ILE C 1 175 ? -44.219 -24.853 35.418  1.00 130.22 ?  169 ILE C O   1 
ATOM   5665 C CB  . ILE C 1 175 ? -42.935 -21.881 34.650  1.00 128.16 ?  169 ILE C CB  1 
ATOM   5666 C CG1 . ILE C 1 175 ? -41.732 -20.944 34.744  1.00 124.26 ?  169 ILE C CG1 1 
ATOM   5667 C CG2 . ILE C 1 175 ? -44.199 -21.018 34.572  1.00 125.85 ?  169 ILE C CG2 1 
ATOM   5668 C CD1 . ILE C 1 175 ? -40.522 -21.429 34.003  1.00 123.79 ?  169 ILE C CD1 1 
ATOM   5669 N N   . GLU C 1 176 ? -45.287 -23.159 36.467  1.00 127.64 ?  170 GLU C N   1 
ATOM   5670 C CA  . GLU C 1 176 ? -46.525 -23.899 36.693  1.00 131.17 ?  170 GLU C CA  1 
ATOM   5671 C C   . GLU C 1 176 ? -47.298 -24.072 35.390  1.00 130.72 ?  170 GLU C C   1 
ATOM   5672 O O   . GLU C 1 176 ? -47.670 -23.082 34.747  1.00 130.10 ?  170 GLU C O   1 
ATOM   5673 C CB  . GLU C 1 176 ? -47.395 -23.174 37.716  1.00 132.63 ?  170 GLU C CB  1 
ATOM   5674 C CG  . GLU C 1 176 ? -46.707 -22.853 39.025  1.00 132.83 ?  170 GLU C CG  1 
ATOM   5675 C CD  . GLU C 1 176 ? -47.503 -21.868 39.858  1.00 140.29 ?  170 GLU C CD  1 
ATOM   5676 O OE1 . GLU C 1 176 ? -48.132 -20.956 39.272  1.00 139.72 ?  170 GLU C OE1 1 
ATOM   5677 O OE2 . GLU C 1 176 ? -47.510 -22.012 41.098  1.00 142.25 ?  170 GLU C OE2 1 
ATOM   5678 N N   . GLY C 1 177 ? -47.566 -25.322 35.022  1.00 126.79 ?  171 GLY C N   1 
ATOM   5679 C CA  . GLY C 1 177 ? -48.332 -25.602 33.824  1.00 127.26 ?  171 GLY C CA  1 
ATOM   5680 C C   . GLY C 1 177 ? -48.318 -27.083 33.493  1.00 129.11 ?  171 GLY C C   1 
ATOM   5681 O O   . GLY C 1 177 ? -47.826 -27.909 34.270  1.00 131.01 ?  171 GLY C O   1 
ATOM   5682 N N   . VAL C 1 178 ? -48.894 -27.398 32.322  1.00 127.97 ?  172 VAL C N   1 
ATOM   5683 C CA  . VAL C 1 178 ? -48.885 -28.756 31.773  1.00 125.02 ?  172 VAL C CA  1 
ATOM   5684 C C   . VAL C 1 178 ? -47.480 -29.334 31.863  1.00 122.37 ?  172 VAL C C   1 
ATOM   5685 O O   . VAL C 1 178 ? -46.519 -28.731 31.376  1.00 124.15 ?  172 VAL C O   1 
ATOM   5686 C CB  . VAL C 1 178 ? -49.403 -28.741 30.318  1.00 120.64 ?  172 VAL C CB  1 
ATOM   5687 C CG1 . VAL C 1 178 ? -48.815 -29.898 29.502  1.00 114.41 ?  172 VAL C CG1 1 
ATOM   5688 C CG2 . VAL C 1 178 ? -50.929 -28.760 30.284  1.00 112.32 ?  172 VAL C CG2 1 
ATOM   5689 N N   . LYS C 1 179 ? -47.361 -30.509 32.490  1.00 121.46 ?  173 LYS C N   1 
ATOM   5690 C CA  . LYS C 1 179 ? -46.058 -31.077 32.830  1.00 115.09 ?  173 LYS C CA  1 
ATOM   5691 C C   . LYS C 1 179 ? -45.131 -31.108 31.622  1.00 115.88 ?  173 LYS C C   1 
ATOM   5692 O O   . LYS C 1 179 ? -45.577 -31.142 30.469  1.00 117.40 ?  173 LYS C O   1 
ATOM   5693 C CB  . LYS C 1 179 ? -46.218 -32.499 33.382  1.00 116.74 ?  173 LYS C CB  1 
ATOM   5694 C CG  . LYS C 1 179 ? -47.013 -32.612 34.680  1.00 124.63 ?  173 LYS C CG  1 
ATOM   5695 C CD  . LYS C 1 179 ? -46.170 -32.280 35.911  1.00 121.97 ?  173 LYS C CD  1 
ATOM   5696 C CE  . LYS C 1 179 ? -47.041 -31.754 37.044  1.00 120.22 ?  173 LYS C CE  1 
ATOM   5697 N NZ  . LYS C 1 179 ? -47.719 -30.481 36.660  1.00 119.61 ?  173 LYS C NZ  1 
ATOM   5698 N N   . ASP C 1 180 ? -43.825 -31.076 31.907  1.00 112.14 ?  174 ASP C N   1 
ATOM   5699 C CA  . ASP C 1 180 ? -42.756 -31.258 30.925  1.00 103.64 ?  174 ASP C CA  1 
ATOM   5700 C C   . ASP C 1 180 ? -42.740 -30.222 29.805  1.00 102.23 ?  174 ASP C C   1 
ATOM   5701 O O   . ASP C 1 180 ? -43.786 -29.769 29.317  1.00 99.03  ?  174 ASP C O   1 
ATOM   5702 C CB  . ASP C 1 180 ? -42.814 -32.662 30.321  1.00 103.82 ?  174 ASP C CB  1 
ATOM   5703 C CG  . ASP C 1 180 ? -41.434 -33.280 30.159  1.00 106.91 ?  174 ASP C CG  1 
ATOM   5704 O OD1 . ASP C 1 180 ? -40.440 -32.650 30.594  1.00 103.56 ?  174 ASP C OD1 1 
ATOM   5705 O OD2 . ASP C 1 180 ? -41.344 -34.395 29.593  1.00 108.78 -1 174 ASP C OD2 1 
ATOM   5706 N N   . ALA C 1 181 ? -41.531 -29.854 29.388  1.00 98.72  ?  175 ALA C N   1 
ATOM   5707 C CA  . ALA C 1 181 ? -41.353 -28.838 28.366  1.00 90.92  ?  175 ALA C CA  1 
ATOM   5708 C C   . ALA C 1 181 ? -39.970 -28.998 27.758  1.00 87.40  ?  175 ALA C C   1 
ATOM   5709 O O   . ALA C 1 181 ? -39.028 -29.431 28.429  1.00 89.89  ?  175 ALA C O   1 
ATOM   5710 C CB  . ALA C 1 181 ? -41.535 -27.427 28.937  1.00 93.14  ?  175 ALA C CB  1 
ATOM   5711 N N   . LEU C 1 182 ? -39.869 -28.668 26.473  1.00 86.22  ?  176 LEU C N   1 
ATOM   5712 C CA  . LEU C 1 182 ? -38.593 -28.607 25.769  1.00 83.66  ?  176 LEU C CA  1 
ATOM   5713 C C   . LEU C 1 182 ? -38.413 -27.196 25.232  1.00 84.09  ?  176 LEU C C   1 
ATOM   5714 O O   . LEU C 1 182 ? -39.276 -26.687 24.506  1.00 83.28  ?  176 LEU C O   1 
ATOM   5715 C CB  . LEU C 1 182 ? -38.528 -29.632 24.635  1.00 79.65  ?  176 LEU C CB  1 
ATOM   5716 C CG  . LEU C 1 182 ? -37.350 -29.456 23.675  1.00 81.54  ?  176 LEU C CG  1 
ATOM   5717 C CD1 . LEU C 1 182 ? -36.069 -30.043 24.263  1.00 85.52  ?  176 LEU C CD1 1 
ATOM   5718 C CD2 . LEU C 1 182 ? -37.645 -30.080 22.325  1.00 76.27  ?  176 LEU C CD2 1 
ATOM   5719 N N   . ALA C 1 183 ? -37.316 -26.553 25.620  1.00 87.68  ?  177 ALA C N   1 
ATOM   5720 C CA  . ALA C 1 183 ? -36.968 -25.230 25.126  1.00 87.92  ?  177 ALA C CA  1 
ATOM   5721 C C   . ALA C 1 183 ? -35.696 -25.327 24.298  1.00 86.24  ?  177 ALA C C   1 
ATOM   5722 O O   . ALA C 1 183 ? -34.748 -26.028 24.671  1.00 86.85  ?  177 ALA C O   1 
ATOM   5723 C CB  . ALA C 1 183 ? -36.786 -24.233 26.269  1.00 88.31  ?  177 ALA C CB  1 
ATOM   5724 N N   . LEU C 1 184 ? -35.694 -24.635 23.163  1.00 82.70  ?  178 LEU C N   1 
ATOM   5725 C CA  . LEU C 1 184 ? -34.591 -24.660 22.219  1.00 83.57  ?  178 LEU C CA  1 
ATOM   5726 C C   . LEU C 1 184 ? -34.116 -23.244 21.934  1.00 81.77  ?  178 LEU C C   1 
ATOM   5727 O O   . LEU C 1 184 ? -34.926 -22.321 21.803  1.00 83.04  ?  178 LEU C O   1 
ATOM   5728 C CB  . LEU C 1 184 ? -35.000 -25.324 20.895  1.00 80.09  ?  178 LEU C CB  1 
ATOM   5729 C CG  . LEU C 1 184 ? -35.658 -26.701 20.896  1.00 76.67  ?  178 LEU C CG  1 
ATOM   5730 C CD1 . LEU C 1 184 ? -35.882 -27.130 19.469  1.00 71.16  ?  178 LEU C CD1 1 
ATOM   5731 C CD2 . LEU C 1 184 ? -34.799 -27.710 21.630  1.00 79.52  ?  178 LEU C CD2 1 
ATOM   5732 N N   . THR C 1 185 ? -32.805 -23.076 21.835  1.00 75.57  ?  179 THR C N   1 
ATOM   5733 C CA  . THR C 1 185 ? -32.250 -21.905 21.184  1.00 77.73  ?  179 THR C CA  1 
ATOM   5734 C C   . THR C 1 185 ? -32.047 -22.238 19.712  1.00 74.98  ?  179 THR C C   1 
ATOM   5735 O O   . THR C 1 185 ? -31.464 -23.270 19.377  1.00 76.85  ?  179 THR C O   1 
ATOM   5736 C CB  . THR C 1 185 ? -30.929 -21.478 21.831  1.00 84.91  ?  179 THR C CB  1 
ATOM   5737 O OG1 . THR C 1 185 ? -30.167 -22.642 22.166  1.00 86.75  ?  179 THR C OG1 1 
ATOM   5738 C CG2 . THR C 1 185 ? -31.180 -20.642 23.098  1.00 79.90  ?  179 THR C CG2 1 
ATOM   5739 N N   . ILE C 1 186 ? -32.554 -21.374 18.838  1.00 72.42  ?  180 ILE C N   1 
ATOM   5740 C CA  . ILE C 1 186 ? -32.432 -21.525 17.395  1.00 69.75  ?  180 ILE C CA  1 
ATOM   5741 C C   . ILE C 1 186 ? -31.619 -20.353 16.893  1.00 70.02  ?  180 ILE C C   1 
ATOM   5742 O O   . ILE C 1 186 ? -31.915 -19.209 17.243  1.00 71.36  ?  180 ILE C O   1 
ATOM   5743 C CB  . ILE C 1 186 ? -33.805 -21.565 16.693  1.00 73.26  ?  180 ILE C CB  1 
ATOM   5744 C CG1 . ILE C 1 186 ? -34.446 -22.955 16.799  1.00 77.07  ?  180 ILE C CG1 1 
ATOM   5745 C CG2 . ILE C 1 186 ? -33.699 -21.126 15.240  1.00 68.58  ?  180 ILE C CG2 1 
ATOM   5746 C CD1 . ILE C 1 186 ? -35.143 -23.190 18.121  1.00 76.62  ?  180 ILE C CD1 1 
ATOM   5747 N N   . PRO C 1 187 ? -30.586 -20.565 16.080  1.00 72.09  ?  181 PRO C N   1 
ATOM   5748 C CA  . PRO C 1 187 ? -29.755 -19.438 15.641  1.00 68.84  ?  181 PRO C CA  1 
ATOM   5749 C C   . PRO C 1 187 ? -30.493 -18.630 14.597  1.00 67.27  ?  181 PRO C C   1 
ATOM   5750 O O   . PRO C 1 187 ? -31.070 -19.184 13.661  1.00 74.55  ?  181 PRO C O   1 
ATOM   5751 C CB  . PRO C 1 187 ? -28.522 -20.115 15.043  1.00 74.76  ?  181 PRO C CB  1 
ATOM   5752 C CG  . PRO C 1 187 ? -29.091 -21.415 14.480  1.00 76.77  ?  181 PRO C CG  1 
ATOM   5753 C CD  . PRO C 1 187 ? -30.223 -21.825 15.407  1.00 73.90  ?  181 PRO C CD  1 
ATOM   5754 N N   . ILE C 1 188 ? -30.488 -17.315 14.765  1.00 69.02  ?  182 ILE C N   1 
ATOM   5755 C CA  . ILE C 1 188 ? -31.060 -16.423 13.772  1.00 71.16  ?  182 ILE C CA  1 
ATOM   5756 C C   . ILE C 1 188 ? -29.995 -15.547 13.130  1.00 65.49  ?  182 ILE C C   1 
ATOM   5757 O O   . ILE C 1 188 ? -30.326 -14.565 12.462  1.00 64.98  ?  182 ILE C O   1 
ATOM   5758 C CB  . ILE C 1 188 ? -32.205 -15.581 14.363  1.00 72.26  ?  182 ILE C CB  1 
ATOM   5759 C CG1 . ILE C 1 188 ? -31.676 -14.492 15.287  1.00 69.86  ?  182 ILE C CG1 1 
ATOM   5760 C CG2 . ILE C 1 188 ? -33.157 -16.464 15.133  1.00 71.96  ?  182 ILE C CG2 1 
ATOM   5761 C CD1 . ILE C 1 188 ? -32.734 -13.519 15.664  1.00 74.97  ?  182 ILE C CD1 1 
ATOM   5762 N N   . GLY C 1 189 ? -28.723 -15.887 13.308  1.00 66.80  ?  183 GLY C N   1 
ATOM   5763 C CA  . GLY C 1 189 ? -27.642 -15.189 12.649  1.00 66.86  ?  183 GLY C CA  1 
ATOM   5764 C C   . GLY C 1 189 ? -26.969 -14.173 13.554  1.00 66.96  ?  183 GLY C C   1 
ATOM   5765 O O   . GLY C 1 189 ? -27.500 -13.760 14.592  1.00 65.80  ?  183 GLY C O   1 
ATOM   5766 N N   . THR C 1 190 ? -25.754 -13.794 13.153  1.00 67.53  ?  184 THR C N   1 
ATOM   5767 C CA  . THR C 1 190 ? -24.949 -12.748 13.805  1.00 70.53  ?  184 THR C CA  1 
ATOM   5768 C C   . THR C 1 190 ? -25.018 -12.853 15.329  1.00 65.79  ?  184 THR C C   1 
ATOM   5769 O O   . THR C 1 190 ? -25.256 -11.876 16.044  1.00 66.32  ?  184 THR C O   1 
ATOM   5770 C CB  . THR C 1 190 ? -25.357 -11.349 13.317  1.00 66.34  ?  184 THR C CB  1 
ATOM   5771 O OG1 . THR C 1 190 ? -26.773 -11.190 13.436  1.00 74.55  ?  184 THR C OG1 1 
ATOM   5772 C CG2 . THR C 1 190 ? -24.993 -11.189 11.841  1.00 66.29  ?  184 THR C CG2 1 
ATOM   5773 N N   . GLY C 1 191 ? -24.800 -14.074 15.818  1.00 58.61  ?  185 GLY C N   1 
ATOM   5774 C CA  . GLY C 1 191 ? -24.767 -14.366 17.233  1.00 59.76  ?  185 GLY C CA  1 
ATOM   5775 C C   . GLY C 1 191 ? -26.090 -14.287 17.953  1.00 65.80  ?  185 GLY C C   1 
ATOM   5776 O O   . GLY C 1 191 ? -26.133 -14.583 19.151  1.00 66.55  ?  185 GLY C O   1 
ATOM   5777 N N   . LEU C 1 192 ? -27.170 -13.902 17.275  1.00 64.58  ?  186 LEU C N   1 
ATOM   5778 C CA  . LEU C 1 192 ? -28.463 -13.770 17.925  1.00 70.24  ?  186 LEU C CA  1 
ATOM   5779 C C   . LEU C 1 192 ? -29.245 -15.062 17.749  1.00 72.13  ?  186 LEU C C   1 
ATOM   5780 O O   . LEU C 1 192 ? -28.995 -15.831 16.820  1.00 74.73  ?  186 LEU C O   1 
ATOM   5781 C CB  . LEU C 1 192 ? -29.235 -12.575 17.364  1.00 69.05  ?  186 LEU C CB  1 
ATOM   5782 C CG  . LEU C 1 192 ? -28.453 -11.251 17.444  1.00 72.61  ?  186 LEU C CG  1 
ATOM   5783 C CD1 . LEU C 1 192 ? -28.952 -10.227 16.432  1.00 70.87  ?  186 LEU C CD1 1 
ATOM   5784 C CD2 . LEU C 1 192 ? -28.467 -10.671 18.852  1.00 71.20  ?  186 LEU C CD2 1 
ATOM   5785 N N   . HIS C 1 193 ? -30.158 -15.327 18.680  1.00 73.05  ?  187 HIS C N   1 
ATOM   5786 C CA  . HIS C 1 193 ? -30.910 -16.575 18.691  1.00 72.15  ?  187 HIS C CA  1 
ATOM   5787 C C   . HIS C 1 193 ? -32.382 -16.287 18.969  1.00 74.22  ?  187 HIS C C   1 
ATOM   5788 O O   . HIS C 1 193 ? -32.727 -15.291 19.604  1.00 78.11  ?  187 HIS C O   1 
ATOM   5789 C CB  . HIS C 1 193 ? -30.343 -17.561 19.734  1.00 67.84  ?  187 HIS C CB  1 
ATOM   5790 C CG  . HIS C 1 193 ? -28.891 -17.917 19.531  1.00 81.06  ?  187 HIS C CG  1 
ATOM   5791 N ND1 . HIS C 1 193 ? -28.190 -17.625 18.374  1.00 85.24  ?  187 HIS C ND1 1 
ATOM   5792 C CD2 . HIS C 1 193 ? -27.995 -18.514 20.360  1.00 86.15  ?  187 HIS C CD2 1 
ATOM   5793 C CE1 . HIS C 1 193 ? -26.937 -18.039 18.492  1.00 75.81  ?  187 HIS C CE1 1 
ATOM   5794 N NE2 . HIS C 1 193 ? -26.791 -18.576 19.689  1.00 79.03  ?  187 HIS C NE2 1 
ATOM   5795 N N   . ARG C 1 194 ? -33.255 -17.158 18.479  1.00 76.91  ?  188 ARG C N   1 
ATOM   5796 C CA  . ARG C 1 194 ? -34.654 -17.168 18.887  1.00 78.08  ?  188 ARG C CA  1 
ATOM   5797 C C   . ARG C 1 194 ? -34.924 -18.401 19.743  1.00 77.89  ?  188 ARG C C   1 
ATOM   5798 O O   . ARG C 1 194 ? -34.297 -19.449 19.568  1.00 77.24  ?  188 ARG C O   1 
ATOM   5799 C CB  . ARG C 1 194 ? -35.593 -17.148 17.674  1.00 77.91  ?  188 ARG C CB  1 
ATOM   5800 C CG  . ARG C 1 194 ? -35.850 -18.518 17.099  1.00 77.10  ?  188 ARG C CG  1 
ATOM   5801 C CD  . ARG C 1 194 ? -36.953 -18.539 16.067  1.00 76.89  ?  188 ARG C CD  1 
ATOM   5802 N NE  . ARG C 1 194 ? -36.773 -17.586 14.977  1.00 74.71  ?  188 ARG C NE  1 
ATOM   5803 C CZ  . ARG C 1 194 ? -36.630 -17.937 13.705  1.00 71.57  ?  188 ARG C CZ  1 
ATOM   5804 N NH1 . ARG C 1 194 ? -36.470 -19.201 13.351  1.00 73.37  ?  188 ARG C NH1 1 
ATOM   5805 N NH2 . ARG C 1 194 ? -36.674 -17.002 12.761  1.00 69.38  ?  188 ARG C NH2 1 
ATOM   5806 N N   . ARG C 1 195 ? -35.841 -18.272 20.690  1.00 80.22  ?  189 ARG C N   1 
ATOM   5807 C CA  . ARG C 1 195 ? -36.160 -19.368 21.594  1.00 84.53  ?  189 ARG C CA  1 
ATOM   5808 C C   . ARG C 1 195 ? -37.521 -19.947 21.229  1.00 88.54  ?  189 ARG C C   1 
ATOM   5809 O O   . ARG C 1 195 ? -38.485 -19.204 21.010  1.00 89.46  ?  189 ARG C O   1 
ATOM   5810 C CB  . ARG C 1 195 ? -36.135 -18.907 23.053  1.00 87.82  ?  189 ARG C CB  1 
ATOM   5811 C CG  . ARG C 1 195 ? -35.028 -17.899 23.358  1.00 96.35  ?  189 ARG C CG  1 
ATOM   5812 C CD  . ARG C 1 195 ? -34.085 -18.360 24.479  1.00 100.83 ?  189 ARG C CD  1 
ATOM   5813 N NE  . ARG C 1 195 ? -33.122 -17.313 24.813  1.00 111.82 ?  189 ARG C NE  1 
ATOM   5814 C CZ  . ARG C 1 195 ? -32.923 -16.817 26.030  1.00 112.49 ?  189 ARG C CZ  1 
ATOM   5815 N NH1 . ARG C 1 195 ? -33.544 -17.310 27.090  1.00 114.18 ?  189 ARG C NH1 1 
ATOM   5816 N NH2 . ARG C 1 195 ? -32.087 -15.792 26.185  1.00 108.68 ?  189 ARG C NH2 1 
ATOM   5817 N N   . MET C 1 196 ? -37.586 -21.270 21.125  1.00 84.96  ?  190 MET C N   1 
ATOM   5818 C CA  . MET C 1 196 ? -38.825 -21.979 20.843  1.00 85.15  ?  190 MET C CA  1 
ATOM   5819 C C   . MET C 1 196 ? -39.040 -22.978 21.961  1.00 81.96  ?  190 MET C C   1 
ATOM   5820 O O   . MET C 1 196 ? -38.156 -23.794 22.240  1.00 81.92  ?  190 MET C O   1 
ATOM   5821 C CB  . MET C 1 196 ? -38.774 -22.668 19.479  1.00 85.75  ?  190 MET C CB  1 
ATOM   5822 C CG  . MET C 1 196 ? -38.677 -21.666 18.330  1.00 86.92  ?  190 MET C CG  1 
ATOM   5823 S SD  . MET C 1 196 ? -38.676 -22.414 16.693  1.00 102.78 ?  190 MET C SD  1 
ATOM   5824 C CE  . MET C 1 196 ? -40.256 -23.261 16.721  1.00 85.60  ?  190 MET C CE  1 
ATOM   5825 N N   . VAL C 1 197 ? -40.186 -22.887 22.629  1.00 81.33  ?  191 VAL C N   1 
ATOM   5826 C CA  . VAL C 1 197 ? -40.491 -23.765 23.750  1.00 87.54  ?  191 VAL C CA  1 
ATOM   5827 C C   . VAL C 1 197 ? -41.680 -24.649 23.384  1.00 84.86  ?  191 VAL C C   1 
ATOM   5828 O O   . VAL C 1 197 ? -42.651 -24.202 22.758  1.00 77.59  ?  191 VAL C O   1 
ATOM   5829 C CB  . VAL C 1 197 ? -40.747 -22.967 25.048  1.00 86.28  ?  191 VAL C CB  1 
ATOM   5830 C CG1 . VAL C 1 197 ? -40.155 -21.580 24.926  1.00 85.83  ?  191 VAL C CG1 1 
ATOM   5831 C CG2 . VAL C 1 197 ? -42.229 -22.913 25.401  1.00 87.52  ?  191 VAL C CG2 1 
ATOM   5832 N N   . TYR C 1 198 ? -41.573 -25.921 23.739  1.00 83.69  ?  192 TYR C N   1 
ATOM   5833 C CA  . TYR C 1 198 ? -42.626 -26.889 23.492  1.00 86.43  ?  192 TYR C CA  1 
ATOM   5834 C C   . TYR C 1 198 ? -43.180 -27.351 24.836  1.00 88.88  ?  192 TYR C C   1 
ATOM   5835 O O   . TYR C 1 198 ? -42.417 -27.581 25.783  1.00 85.22  ?  192 TYR C O   1 
ATOM   5836 C CB  . TYR C 1 198 ? -42.094 -28.063 22.654  1.00 80.45  ?  192 TYR C CB  1 
ATOM   5837 C CG  . TYR C 1 198 ? -41.613 -27.641 21.273  1.00 77.05  ?  192 TYR C CG  1 
ATOM   5838 C CD1 . TYR C 1 198 ? -42.516 -27.289 20.279  1.00 74.79  ?  192 TYR C CD1 1 
ATOM   5839 C CD2 . TYR C 1 198 ? -40.255 -27.568 20.972  1.00 78.40  ?  192 TYR C CD2 1 
ATOM   5840 C CE1 . TYR C 1 198 ? -42.093 -26.891 19.018  1.00 73.43  ?  192 TYR C CE1 1 
ATOM   5841 C CE2 . TYR C 1 198 ? -39.813 -27.170 19.704  1.00 76.03  ?  192 TYR C CE2 1 
ATOM   5842 C CZ  . TYR C 1 198 ? -40.740 -26.833 18.727  1.00 78.70  ?  192 TYR C CZ  1 
ATOM   5843 O OH  . TYR C 1 198 ? -40.324 -26.438 17.461  1.00 71.82  ?  192 TYR C OH  1 
ATOM   5844 N N   . VAL C 1 199 ? -44.513 -27.425 24.930  1.00 92.96  ?  193 VAL C N   1 
ATOM   5845 C CA  . VAL C 1 199 ? -45.219 -27.836 26.154  1.00 93.06  ?  193 VAL C CA  1 
ATOM   5846 C C   . VAL C 1 199 ? -46.306 -28.870 25.866  1.00 91.41  ?  193 VAL C C   1 
ATOM   5847 O O   . VAL C 1 199 ? -46.866 -29.474 26.789  1.00 98.22  ?  193 VAL C O   1 
ATOM   5848 C CB  . VAL C 1 199 ? -45.834 -26.628 26.876  1.00 92.60  ?  193 VAL C CB  1 
ATOM   5849 C CG1 . VAL C 1 199 ? -44.822 -25.510 27.018  1.00 93.22  ?  193 VAL C CG1 1 
ATOM   5850 C CG2 . VAL C 1 199 ? -47.040 -26.136 26.111  1.00 90.59  ?  193 VAL C CG2 1 
ATOM   5851 N N   . PHE C 1 220 ? -35.201 -14.067 29.660  1.00 119.68 ?  214 PHE C N   1 
ATOM   5852 C CA  . PHE C 1 220 ? -36.185 -14.992 29.108  1.00 119.73 ?  214 PHE C CA  1 
ATOM   5853 C C   . PHE C 1 220 ? -37.277 -14.241 28.339  1.00 121.44 ?  214 PHE C C   1 
ATOM   5854 O O   . PHE C 1 220 ? -38.307 -14.822 27.987  1.00 118.33 ?  214 PHE C O   1 
ATOM   5855 C CB  . PHE C 1 220 ? -36.807 -15.850 30.227  1.00 119.01 ?  214 PHE C CB  1 
ATOM   5856 C CG  . PHE C 1 220 ? -37.822 -15.116 31.087  1.00 118.52 ?  214 PHE C CG  1 
ATOM   5857 C CD1 . PHE C 1 220 ? -37.422 -14.116 31.962  1.00 114.98 ?  214 PHE C CD1 1 
ATOM   5858 C CD2 . PHE C 1 220 ? -39.176 -15.441 31.026  1.00 116.08 ?  214 PHE C CD2 1 
ATOM   5859 C CE1 . PHE C 1 220 ? -38.347 -13.455 32.748  1.00 111.72 ?  214 PHE C CE1 1 
ATOM   5860 C CE2 . PHE C 1 220 ? -40.112 -14.775 31.810  1.00 108.00 ?  214 PHE C CE2 1 
ATOM   5861 C CZ  . PHE C 1 220 ? -39.696 -13.785 32.669  1.00 110.33 ?  214 PHE C CZ  1 
ATOM   5862 N N   . VAL C 1 221 ? -37.041 -12.954 28.070  1.00 121.81 ?  215 VAL C N   1 
ATOM   5863 C CA  . VAL C 1 221 ? -38.069 -12.083 27.502  1.00 120.75 ?  215 VAL C CA  1 
ATOM   5864 C C   . VAL C 1 221 ? -37.436 -11.033 26.595  1.00 119.39 ?  215 VAL C C   1 
ATOM   5865 O O   . VAL C 1 221 ? -38.141 -10.263 25.930  1.00 117.51 ?  215 VAL C O   1 
ATOM   5866 C CB  . VAL C 1 221 ? -38.897 -11.418 28.619  1.00 118.65 ?  215 VAL C CB  1 
ATOM   5867 C CG1 . VAL C 1 221 ? -38.113 -10.273 29.246  1.00 117.36 ?  215 VAL C CG1 1 
ATOM   5868 C CG2 . VAL C 1 221 ? -40.261 -10.952 28.092  1.00 111.18 ?  215 VAL C CG2 1 
ATOM   5869 N N   . HIS C 1 222 ? -36.106 -10.999 26.555  1.00 121.73 ?  216 HIS C N   1 
ATOM   5870 C CA  . HIS C 1 222 ? -35.374 -10.028 25.750  1.00 118.91 ?  216 HIS C CA  1 
ATOM   5871 C C   . HIS C 1 222 ? -35.042 -10.535 24.352  1.00 113.92 ?  216 HIS C C   1 
ATOM   5872 O O   . HIS C 1 222 ? -34.381 -9.821  23.591  1.00 112.77 ?  216 HIS C O   1 
ATOM   5873 C CB  . HIS C 1 222 ? -34.092 -9.609  26.473  1.00 121.37 ?  216 HIS C CB  1 
ATOM   5874 C CG  . HIS C 1 222 ? -34.306 -9.227  27.907  1.00 126.96 ?  216 HIS C CG  1 
ATOM   5875 N ND1 . HIS C 1 222 ? -34.944 -8.062  28.281  1.00 124.94 ?  216 HIS C ND1 1 
ATOM   5876 C CD2 . HIS C 1 222 ? -33.966 -9.856  29.059  1.00 127.97 ?  216 HIS C CD2 1 
ATOM   5877 C CE1 . HIS C 1 222 ? -34.987 -7.989  29.600  1.00 124.74 ?  216 HIS C CE1 1 
ATOM   5878 N NE2 . HIS C 1 222 ? -34.400 -9.064  30.096  1.00 130.88 ?  216 HIS C NE2 1 
ATOM   5879 N N   . ASP C 1 223 ? -35.477 -11.745 24.000  1.00 115.08 ?  217 ASP C N   1 
ATOM   5880 C CA  . ASP C 1 223 ? -35.356 -12.267 22.646  1.00 107.18 ?  217 ASP C CA  1 
ATOM   5881 C C   . ASP C 1 223 ? -36.675 -12.928 22.269  1.00 100.81 ?  217 ASP C C   1 
ATOM   5882 O O   . ASP C 1 223 ? -37.459 -13.336 23.135  1.00 97.22  ?  217 ASP C O   1 
ATOM   5883 C CB  . ASP C 1 223 ? -34.187 -13.258 22.513  1.00 105.12 ?  217 ASP C CB  1 
ATOM   5884 C CG  . ASP C 1 223 ? -33.774 -13.860 23.853  1.00 109.90 ?  217 ASP C CG  1 
ATOM   5885 O OD1 . ASP C 1 223 ? -34.664 -13.994 24.730  1.00 112.82 ?  217 ASP C OD1 1 
ATOM   5886 O OD2 . ASP C 1 223 ? -32.573 -14.195 24.027  1.00 101.35 -1 217 ASP C OD2 1 
ATOM   5887 N N   . GLU C 1 224 ? -36.910 -13.023 20.959  1.00 94.40  ?  218 GLU C N   1 
ATOM   5888 C CA  . GLU C 1 224 ? -38.196 -13.484 20.448  1.00 91.91  ?  218 GLU C CA  1 
ATOM   5889 C C   . GLU C 1 224 ? -38.443 -14.942 20.813  1.00 89.95  ?  218 GLU C C   1 
ATOM   5890 O O   . GLU C 1 224 ? -37.614 -15.821 20.550  1.00 89.56  ?  218 GLU C O   1 
ATOM   5891 C CB  . GLU C 1 224 ? -38.260 -13.315 18.935  1.00 85.15  ?  218 GLU C CB  1 
ATOM   5892 C CG  . GLU C 1 224 ? -36.978 -13.646 18.223  1.00 83.10  ?  218 GLU C CG  1 
ATOM   5893 C CD  . GLU C 1 224 ? -37.214 -13.990 16.778  1.00 83.49  ?  218 GLU C CD  1 
ATOM   5894 O OE1 . GLU C 1 224 ? -38.300 -14.524 16.462  1.00 78.44  ?  218 GLU C OE1 1 
ATOM   5895 O OE2 . GLU C 1 224 ? -36.314 -13.721 15.959  1.00 87.22  -1 218 GLU C OE2 1 
ATOM   5896 N N   . THR C 1 225 ? -39.595 -15.201 21.408  1.00 86.93  ?  219 THR C N   1 
ATOM   5897 C CA  . THR C 1 225 ? -39.946 -16.533 21.860  1.00 89.72  ?  219 THR C CA  1 
ATOM   5898 C C   . THR C 1 225 ? -41.204 -17.004 21.144  1.00 85.81  ?  219 THR C C   1 
ATOM   5899 O O   . THR C 1 225 ? -42.087 -16.207 20.826  1.00 85.83  ?  219 THR C O   1 
ATOM   5900 C CB  . THR C 1 225 ? -40.125 -16.551 23.379  1.00 88.32  ?  219 THR C CB  1 
ATOM   5901 O OG1 . THR C 1 225 ? -38.829 -16.469 23.991  1.00 89.71  ?  219 THR C OG1 1 
ATOM   5902 C CG2 . THR C 1 225 ? -40.811 -17.824 23.830  1.00 87.00  ?  219 THR C CG2 1 
ATOM   5903 N N   . HIS C 1 226 ? -41.242 -18.290 20.831  1.00 86.53  ?  220 HIS C N   1 
ATOM   5904 C CA  . HIS C 1 226 ? -42.416 -18.923 20.263  1.00 81.90  ?  220 HIS C CA  1 
ATOM   5905 C C   . HIS C 1 226 ? -42.763 -20.118 21.136  1.00 85.62  ?  220 HIS C C   1 
ATOM   5906 O O   . HIS C 1 226 ? -41.869 -20.811 21.636  1.00 86.80  ?  220 HIS C O   1 
ATOM   5907 C CB  . HIS C 1 226 ? -42.171 -19.362 18.819  1.00 81.34  ?  220 HIS C CB  1 
ATOM   5908 C CG  . HIS C 1 226 ? -41.650 -18.274 17.931  1.00 84.79  ?  220 HIS C CG  1 
ATOM   5909 N ND1 . HIS C 1 226 ? -42.423 -17.674 16.959  1.00 83.23  ?  220 HIS C ND1 1 
ATOM   5910 C CD2 . HIS C 1 226 ? -40.426 -17.697 17.848  1.00 83.80  ?  220 HIS C CD2 1 
ATOM   5911 C CE1 . HIS C 1 226 ? -41.705 -16.761 16.328  1.00 78.34  ?  220 HIS C CE1 1 
ATOM   5912 N NE2 . HIS C 1 226 ? -40.489 -16.755 16.847  1.00 82.97  ?  220 HIS C NE2 1 
ATOM   5913 N N   . VAL C 1 227 ? -44.059 -20.348 21.338  1.00 88.26  ?  221 VAL C N   1 
ATOM   5914 C CA  . VAL C 1 227 ? -44.532 -21.412 22.214  1.00 84.18  ?  221 VAL C CA  1 
ATOM   5915 C C   . VAL C 1 227 ? -45.494 -22.298 21.435  1.00 85.21  ?  221 VAL C C   1 
ATOM   5916 O O   . VAL C 1 227 ? -46.347 -21.808 20.687  1.00 84.56  ?  221 VAL C O   1 
ATOM   5917 C CB  . VAL C 1 227 ? -45.211 -20.850 23.479  1.00 80.19  ?  221 VAL C CB  1 
ATOM   5918 C CG1 . VAL C 1 227 ? -45.939 -21.953 24.223  1.00 82.02  ?  221 VAL C CG1 1 
ATOM   5919 C CG2 . VAL C 1 227 ? -44.190 -20.163 24.374  1.00 80.22  ?  221 VAL C CG2 1 
ATOM   5920 N N   . LEU C 1 228 ? -45.337 -23.606 21.602  1.00 83.65  ?  222 LEU C N   1 
ATOM   5921 C CA  . LEU C 1 228 ? -46.227 -24.601 21.031  1.00 85.41  ?  222 LEU C CA  1 
ATOM   5922 C C   . LEU C 1 228 ? -46.531 -25.654 22.088  1.00 90.65  ?  222 LEU C C   1 
ATOM   5923 O O   . LEU C 1 228 ? -45.652 -26.023 22.873  1.00 89.47  ?  222 LEU C O   1 
ATOM   5924 C CB  . LEU C 1 228 ? -45.603 -25.241 19.797  1.00 78.08  ?  222 LEU C CB  1 
ATOM   5925 C CG  . LEU C 1 228 ? -46.036 -24.605 18.491  1.00 82.72  ?  222 LEU C CG  1 
ATOM   5926 C CD1 . LEU C 1 228 ? -44.974 -24.783 17.427  1.00 80.34  ?  222 LEU C CD1 1 
ATOM   5927 C CD2 . LEU C 1 228 ? -47.329 -25.268 18.078  1.00 88.10  ?  222 LEU C CD2 1 
ATOM   5928 N N   . GLN C 1 229 ? -47.779 -26.115 22.128  1.00 92.18  ?  223 GLN C N   1 
ATOM   5929 C CA  . GLN C 1 229 ? -48.137 -27.238 22.981  1.00 94.61  ?  223 GLN C CA  1 
ATOM   5930 C C   . GLN C 1 229 ? -48.031 -28.512 22.161  1.00 95.93  ?  223 GLN C C   1 
ATOM   5931 O O   . GLN C 1 229 ? -48.374 -28.535 20.974  1.00 94.58  ?  223 GLN C O   1 
ATOM   5932 C CB  . GLN C 1 229 ? -49.550 -27.093 23.570  1.00 98.29  ?  223 GLN C CB  1 
ATOM   5933 C CG  . GLN C 1 229 ? -50.037 -28.330 24.370  1.00 104.66 ?  223 GLN C CG  1 
ATOM   5934 C CD  . GLN C 1 229 ? -50.879 -27.990 25.608  1.00 102.89 ?  223 GLN C CD  1 
ATOM   5935 O OE1 . GLN C 1 229 ? -50.607 -28.467 26.718  1.00 106.11 ?  223 GLN C OE1 1 
ATOM   5936 N NE2 . GLN C 1 229 ? -51.917 -27.187 25.412  1.00 90.33  ?  223 GLN C NE2 1 
ATOM   5937 N N   . VAL C 1 230 ? -47.518 -29.563 22.794  1.00 96.09  ?  224 VAL C N   1 
ATOM   5938 C CA  . VAL C 1 230 ? -47.310 -30.841 22.138  1.00 91.25  ?  224 VAL C CA  1 
ATOM   5939 C C   . VAL C 1 230 ? -47.847 -31.937 23.041  1.00 95.01  ?  224 VAL C C   1 
ATOM   5940 O O   . VAL C 1 230 ? -48.032 -31.752 24.248  1.00 95.06  ?  224 VAL C O   1 
ATOM   5941 C CB  . VAL C 1 230 ? -45.824 -31.089 21.824  1.00 89.61  ?  224 VAL C CB  1 
ATOM   5942 C CG1 . VAL C 1 230 ? -45.412 -30.308 20.587  1.00 90.07  ?  224 VAL C CG1 1 
ATOM   5943 C CG2 . VAL C 1 230 ? -44.982 -30.697 23.022  1.00 86.75  ?  224 VAL C CG2 1 
ATOM   5944 N N   . ASP C 1 231 ? -48.095 -33.092 22.433  1.00 92.99  ?  225 ASP C N   1 
ATOM   5945 C CA  . ASP C 1 231 ? -48.494 -34.270 23.183  1.00 91.94  ?  225 ASP C CA  1 
ATOM   5946 C C   . ASP C 1 231 ? -47.371 -34.743 24.098  1.00 94.72  ?  225 ASP C C   1 
ATOM   5947 O O   . ASP C 1 231 ? -47.509 -34.713 25.327  1.00 98.24  ?  225 ASP C O   1 
ATOM   5948 C CB  . ASP C 1 231 ? -48.900 -35.390 22.226  1.00 98.30  ?  225 ASP C CB  1 
ATOM   5949 C CG  . ASP C 1 231 ? -50.401 -35.538 22.103  1.00 101.56 ?  225 ASP C CG  1 
ATOM   5950 O OD1 . ASP C 1 231 ? -51.111 -34.509 22.161  1.00 104.38 ?  225 ASP C OD1 1 
ATOM   5951 O OD2 . ASP C 1 231 ? -50.867 -36.692 21.973  1.00 106.42 -1 225 ASP C OD2 1 
ATOM   5952 N N   . ASP C 1 232 ? -46.255 -35.183 23.509  1.00 94.10  ?  226 ASP C N   1 
ATOM   5953 C CA  . ASP C 1 232 ? -45.130 -35.772 24.241  1.00 86.36  ?  226 ASP C CA  1 
ATOM   5954 C C   . ASP C 1 232 ? -43.859 -34.999 23.898  1.00 80.11  ?  226 ASP C C   1 
ATOM   5955 O O   . ASP C 1 232 ? -43.272 -35.205 22.832  1.00 78.38  ?  226 ASP C O   1 
ATOM   5956 C CB  . ASP C 1 232 ? -44.973 -37.254 23.907  1.00 80.95  ?  226 ASP C CB  1 
ATOM   5957 C CG  . ASP C 1 232 ? -43.990 -37.955 24.819  1.00 83.22  ?  226 ASP C CG  1 
ATOM   5958 O OD1 . ASP C 1 232 ? -43.604 -37.366 25.851  1.00 84.96  ?  226 ASP C OD1 1 
ATOM   5959 O OD2 . ASP C 1 232 ? -43.599 -39.101 24.505  1.00 89.20  -1 226 ASP C OD2 1 
ATOM   5960 N N   . VAL C 1 233 ? -43.447 -34.116 24.813  1.00 78.68  ?  227 VAL C N   1 
ATOM   5961 C CA  . VAL C 1 233 ? -42.189 -33.385 24.694  1.00 76.77  ?  227 VAL C CA  1 
ATOM   5962 C C   . VAL C 1 233 ? -41.005 -34.340 24.552  1.00 76.09  ?  227 VAL C C   1 
ATOM   5963 O O   . VAL C 1 233 ? -40.044 -34.047 23.831  1.00 71.97  ?  227 VAL C O   1 
ATOM   5964 C CB  . VAL C 1 233 ? -42.031 -32.445 25.911  1.00 80.04  ?  227 VAL C CB  1 
ATOM   5965 C CG1 . VAL C 1 233 ? -40.590 -32.182 26.228  1.00 77.66  ?  227 VAL C CG1 1 
ATOM   5966 C CG2 . VAL C 1 233 ? -42.774 -31.143 25.686  1.00 81.30  ?  227 VAL C CG2 1 
ATOM   5967 N N   . LYS C 1 234 ? -41.056 -35.503 25.205  1.00 75.32  ?  228 LYS C N   1 
ATOM   5968 C CA  . LYS C 1 234 ? -39.952 -36.448 25.081  1.00 77.74  ?  228 LYS C CA  1 
ATOM   5969 C C   . LYS C 1 234 ? -39.744 -36.926 23.639  1.00 74.41  ?  228 LYS C C   1 
ATOM   5970 O O   . LYS C 1 234 ? -38.628 -37.316 23.284  1.00 71.35  ?  228 LYS C O   1 
ATOM   5971 C CB  . LYS C 1 234 ? -40.173 -37.643 26.020  1.00 81.14  ?  228 LYS C CB  1 
ATOM   5972 C CG  . LYS C 1 234 ? -40.029 -37.315 27.518  1.00 80.21  ?  228 LYS C CG  1 
ATOM   5973 C CD  . LYS C 1 234 ? -40.547 -38.457 28.403  1.00 84.70  ?  228 LYS C CD  1 
ATOM   5974 C CE  . LYS C 1 234 ? -41.730 -39.208 27.753  1.00 91.71  ?  228 LYS C CE  1 
ATOM   5975 N NZ  . LYS C 1 234 ? -42.013 -40.569 28.348  1.00 91.47  ?  228 LYS C NZ  1 
ATOM   5976 N N   . GLN C 1 235 ? -40.782 -36.883 22.797  1.00 72.01  ?  229 GLN C N   1 
ATOM   5977 C CA  . GLN C 1 235 ? -40.670 -37.319 21.408  1.00 67.83  ?  229 GLN C CA  1 
ATOM   5978 C C   . GLN C 1 235 ? -39.848 -36.359 20.546  1.00 71.00  ?  229 GLN C C   1 
ATOM   5979 O O   . GLN C 1 235 ? -39.414 -36.738 19.450  1.00 71.07  ?  229 GLN C O   1 
ATOM   5980 C CB  . GLN C 1 235 ? -42.071 -37.475 20.817  1.00 71.19  ?  229 GLN C CB  1 
ATOM   5981 C CG  . GLN C 1 235 ? -42.178 -38.384 19.604  1.00 69.73  ?  229 GLN C CG  1 
ATOM   5982 C CD  . GLN C 1 235 ? -41.926 -39.859 19.929  1.00 77.78  ?  229 GLN C CD  1 
ATOM   5983 O OE1 . GLN C 1 235 ? -42.241 -40.341 21.032  1.00 76.31  ?  229 GLN C OE1 1 
ATOM   5984 N NE2 . GLN C 1 235 ? -41.383 -40.593 18.950  1.00 73.39  ?  229 GLN C NE2 1 
ATOM   5985 N N   . LEU C 1 236 ? -39.615 -35.133 21.007  1.00 67.75  ?  230 LEU C N   1 
ATOM   5986 C CA  . LEU C 1 236 ? -38.907 -34.133 20.219  1.00 63.19  ?  230 LEU C CA  1 
ATOM   5987 C C   . LEU C 1 236 ? -37.407 -34.088 20.501  1.00 64.66  ?  230 LEU C C   1 
ATOM   5988 O O   . LEU C 1 236 ? -36.688 -33.358 19.812  1.00 68.18  ?  230 LEU C O   1 
ATOM   5989 C CB  . LEU C 1 236 ? -39.542 -32.757 20.466  1.00 62.10  ?  230 LEU C CB  1 
ATOM   5990 C CG  . LEU C 1 236 ? -41.069 -32.904 20.435  1.00 68.68  ?  230 LEU C CG  1 
ATOM   5991 C CD1 . LEU C 1 236 ? -41.794 -31.669 20.902  1.00 70.58  ?  230 LEU C CD1 1 
ATOM   5992 C CD2 . LEU C 1 236 ? -41.521 -33.291 19.034  1.00 67.74  ?  230 LEU C CD2 1 
ATOM   5993 N N   . ILE C 1 237 ? -36.908 -34.878 21.450  1.00 64.79  ?  231 ILE C N   1 
ATOM   5994 C CA  . ILE C 1 237 ? -35.571 -34.671 22.005  1.00 67.64  ?  231 ILE C CA  1 
ATOM   5995 C C   . ILE C 1 237 ? -34.509 -35.333 21.130  1.00 67.88  ?  231 ILE C C   1 
ATOM   5996 O O   . ILE C 1 237 ? -34.627 -36.508 20.758  1.00 70.75  ?  231 ILE C O   1 
ATOM   5997 C CB  . ILE C 1 237 ? -35.500 -35.189 23.453  1.00 68.11  ?  231 ILE C CB  1 
ATOM   5998 C CG1 . ILE C 1 237 ? -36.199 -34.220 24.401  1.00 72.84  ?  231 ILE C CG1 1 
ATOM   5999 C CG2 . ILE C 1 237 ? -34.068 -35.352 23.900  1.00 69.86  ?  231 ILE C CG2 1 
ATOM   6000 C CD1 . ILE C 1 237 ? -36.765 -34.901 25.620  1.00 76.14  ?  231 ILE C CD1 1 
ATOM   6001 N N   . ASP C 1 238 ? -33.454 -34.584 20.815  1.00 62.31  ?  232 ASP C N   1 
ATOM   6002 C CA  . ASP C 1 238 ? -32.296 -35.140 20.133  1.00 59.86  ?  232 ASP C CA  1 
ATOM   6003 C C   . ASP C 1 238 ? -31.057 -34.356 20.549  1.00 65.32  ?  232 ASP C C   1 
ATOM   6004 O O   . ASP C 1 238 ? -31.066 -33.122 20.570  1.00 69.27  ?  232 ASP C O   1 
ATOM   6005 C CB  . ASP C 1 238 ? -32.474 -35.109 18.616  1.00 63.60  ?  232 ASP C CB  1 
ATOM   6006 C CG  . ASP C 1 238 ? -31.153 -35.260 17.873  1.00 68.22  ?  232 ASP C CG  1 
ATOM   6007 O OD1 . ASP C 1 238 ? -30.709 -36.424 17.644  1.00 66.11  -1 232 ASP C OD1 1 
ATOM   6008 O OD2 . ASP C 1 238 ? -30.552 -34.206 17.538  1.00 66.64  ?  232 ASP C OD2 1 
ATOM   6009 N N   . ARG C 1 239 ? -29.990 -35.071 20.872  1.00 63.07  ?  233 ARG C N   1 
ATOM   6010 C CA  . ARG C 1 239 ? -28.828 -34.454 21.489  1.00 67.60  ?  233 ARG C CA  1 
ATOM   6011 C C   . ARG C 1 239 ? -27.776 -34.008 20.475  1.00 64.88  ?  233 ARG C C   1 
ATOM   6012 O O   . ARG C 1 239 ? -26.683 -33.621 20.880  1.00 61.38  ?  233 ARG C O   1 
ATOM   6013 C CB  . ARG C 1 239 ? -28.223 -35.415 22.516  1.00 63.30  ?  233 ARG C CB  1 
ATOM   6014 C CG  . ARG C 1 239 ? -29.285 -35.958 23.470  1.00 69.53  ?  233 ARG C CG  1 
ATOM   6015 C CD  . ARG C 1 239 ? -28.751 -36.261 24.860  1.00 74.38  ?  233 ARG C CD  1 
ATOM   6016 N NE  . ARG C 1 239 ? -29.565 -35.634 25.901  1.00 80.42  ?  233 ARG C NE  1 
ATOM   6017 C CZ  . ARG C 1 239 ? -30.702 -36.127 26.382  1.00 93.14  ?  233 ARG C CZ  1 
ATOM   6018 N NH1 . ARG C 1 239 ? -31.194 -37.292 25.964  1.00 88.33  ?  233 ARG C NH1 1 
ATOM   6019 N NH2 . ARG C 1 239 ? -31.367 -35.434 27.305  1.00 101.87 ?  233 ARG C NH2 1 
ATOM   6020 N N   . GLY C 1 240 ? -28.076 -34.049 19.172  1.00 60.15  ?  234 GLY C N   1 
ATOM   6021 C CA  . GLY C 1 240 ? -27.183 -33.452 18.209  1.00 59.72  ?  234 GLY C CA  1 
ATOM   6022 C C   . GLY C 1 240 ? -27.323 -31.939 18.180  1.00 63.56  ?  234 GLY C C   1 
ATOM   6023 O O   . GLY C 1 240 ? -28.334 -31.357 18.581  1.00 63.99  ?  234 GLY C O   1 
ATOM   6024 N N   . ILE C 1 241 ? -26.277 -31.267 17.713  1.00 57.60  ?  235 ILE C N   1 
ATOM   6025 C CA  . ILE C 1 241 ? -26.320 -29.817 17.628  1.00 55.77  ?  235 ILE C CA  1 
ATOM   6026 C C   . ILE C 1 241 ? -25.443 -29.375 16.473  1.00 56.51  ?  235 ILE C C   1 
ATOM   6027 O O   . ILE C 1 241 ? -24.517 -30.080 16.066  1.00 58.99  ?  235 ILE C O   1 
ATOM   6028 C CB  . ILE C 1 241 ? -25.924 -29.153 18.972  1.00 59.33  ?  235 ILE C CB  1 
ATOM   6029 C CG1 . ILE C 1 241 ? -26.553 -27.765 19.086  1.00 66.66  ?  235 ILE C CG1 1 
ATOM   6030 C CG2 . ILE C 1 241 ? -24.407 -29.142 19.206  1.00 59.00  ?  235 ILE C CG2 1 
ATOM   6031 C CD1 . ILE C 1 241 ? -26.922 -27.386 20.512  1.00 75.33  ?  235 ILE C CD1 1 
ATOM   6032 N N   . GLY C 1 242 ? -25.781 -28.222 15.908  1.00 61.37  ?  236 GLY C N   1 
ATOM   6033 C CA  . GLY C 1 242 ? -24.982 -27.590 14.876  1.00 60.96  ?  236 GLY C CA  1 
ATOM   6034 C C   . GLY C 1 242 ? -24.294 -26.356 15.435  1.00 63.78  ?  236 GLY C C   1 
ATOM   6035 O O   . GLY C 1 242 ? -24.827 -25.665 16.309  1.00 62.20  ?  236 GLY C O   1 
ATOM   6036 N N   . VAL C 1 243 ? -23.088 -26.094 14.957  1.00 59.11  ?  237 VAL C N   1 
ATOM   6037 C CA  . VAL C 1 243 ? -22.359 -24.897 15.347  1.00 57.42  ?  237 VAL C CA  1 
ATOM   6038 C C   . VAL C 1 243 ? -21.797 -24.290 14.078  1.00 57.65  ?  237 VAL C C   1 
ATOM   6039 O O   . VAL C 1 243 ? -21.052 -24.963 13.350  1.00 60.86  ?  237 VAL C O   1 
ATOM   6040 C CB  . VAL C 1 243 ? -21.234 -25.208 16.346  1.00 60.89  ?  237 VAL C CB  1 
ATOM   6041 C CG1 . VAL C 1 243 ? -20.410 -23.963 16.610  1.00 63.02  ?  237 VAL C CG1 1 
ATOM   6042 C CG2 . VAL C 1 243 ? -21.812 -25.754 17.638  1.00 58.55  ?  237 VAL C CG2 1 
ATOM   6043 N N   . ARG C 1 244 ? -22.171 -23.043 13.791  1.00 54.19  ?  238 ARG C N   1 
ATOM   6044 C CA  . ARG C 1 244 ? -21.568 -22.282 12.702  1.00 59.83  ?  238 ARG C CA  1 
ATOM   6045 C C   . ARG C 1 244 ? -20.871 -21.062 13.293  1.00 59.26  ?  238 ARG C C   1 
ATOM   6046 O O   . ARG C 1 244 ? -21.519 -20.218 13.918  1.00 62.73  ?  238 ARG C O   1 
ATOM   6047 C CB  . ARG C 1 244 ? -22.602 -21.865 11.652  1.00 56.40  ?  238 ARG C CB  1 
ATOM   6048 C CG  . ARG C 1 244 ? -21.990 -21.097 10.486  1.00 67.10  ?  238 ARG C CG  1 
ATOM   6049 C CD  . ARG C 1 244 ? -22.853 -21.076 9.213   1.00 71.37  ?  238 ARG C CD  1 
ATOM   6050 N NE  . ARG C 1 244 ? -22.255 -20.202 8.205   1.00 80.57  ?  238 ARG C NE  1 
ATOM   6051 C CZ  . ARG C 1 244 ? -21.765 -20.599 7.033   1.00 81.53  ?  238 ARG C CZ  1 
ATOM   6052 N NH1 . ARG C 1 244 ? -21.870 -21.858 6.623   1.00 75.17  ?  238 ARG C NH1 1 
ATOM   6053 N NH2 . ARG C 1 244 ? -21.142 -19.712 6.254   1.00 81.31  ?  238 ARG C NH2 1 
ATOM   6054 N N   . MET C 1 245 ? -19.558 -20.970 13.102  1.00 61.18  ?  239 MET C N   1 
ATOM   6055 C CA  . MET C 1 245 ? -18.762 -19.862 13.620  1.00 59.60  ?  239 MET C CA  1 
ATOM   6056 C C   . MET C 1 245 ? -18.103 -19.146 12.453  1.00 57.96  ?  239 MET C C   1 
ATOM   6057 O O   . MET C 1 245 ? -17.549 -19.802 11.564  1.00 60.30  ?  239 MET C O   1 
ATOM   6058 C CB  . MET C 1 245 ? -17.727 -20.375 14.604  1.00 58.59  ?  239 MET C CB  1 
ATOM   6059 C CG  . MET C 1 245 ? -16.710 -19.372 15.095  1.00 63.17  ?  239 MET C CG  1 
ATOM   6060 S SD  . MET C 1 245 ? -15.644 -20.196 16.323  1.00 70.43  ?  239 MET C SD  1 
ATOM   6061 C CE  . MET C 1 245 ? -16.742 -21.501 16.901  1.00 67.20  ?  239 MET C CE  1 
ATOM   6062 N N   . GLU C 1 246 ? -18.219 -17.815 12.414  1.00 53.99  ?  240 GLU C N   1 
ATOM   6063 C CA  . GLU C 1 246 ? -17.667 -17.030 11.313  1.00 61.39  ?  240 GLU C CA  1 
ATOM   6064 C C   . GLU C 1 246 ? -16.903 -15.826 11.833  1.00 58.07  ?  240 GLU C C   1 
ATOM   6065 O O   . GLU C 1 246 ? -17.223 -15.262 12.886  1.00 54.76  ?  240 GLU C O   1 
ATOM   6066 C CB  . GLU C 1 246 ? -18.726 -16.492 10.333  1.00 59.19  ?  240 GLU C CB  1 
ATOM   6067 C CG  . GLU C 1 246 ? -19.753 -17.485 9.881   1.00 76.41  ?  240 GLU C CG  1 
ATOM   6068 C CD  . GLU C 1 246 ? -20.972 -16.800 9.264   1.00 90.83  ?  240 GLU C CD  1 
ATOM   6069 O OE1 . GLU C 1 246 ? -21.443 -15.771 9.829   1.00 89.75  ?  240 GLU C OE1 1 
ATOM   6070 O OE2 . GLU C 1 246 ? -21.477 -17.323 8.236   1.00 95.41  -1 240 GLU C OE2 1 
ATOM   6071 N N   . ARG C 1 247 ? -15.906 -15.423 11.050  1.00 53.60  ?  241 ARG C N   1 
ATOM   6072 C CA  . ARG C 1 247 ? -15.180 -14.185 11.271  1.00 53.74  ?  241 ARG C CA  1 
ATOM   6073 C C   . ARG C 1 247 ? -14.871 -13.617 9.903   1.00 54.09  ?  241 ARG C C   1 
ATOM   6074 O O   . ARG C 1 247 ? -14.440 -14.347 9.004   1.00 56.42  ?  241 ARG C O   1 
ATOM   6075 C CB  . ARG C 1 247 ? -13.878 -14.391 12.076  1.00 56.06  ?  241 ARG C CB  1 
ATOM   6076 C CG  . ARG C 1 247 ? -13.040 -13.093 12.290  1.00 54.41  ?  241 ARG C CG  1 
ATOM   6077 C CD  . ARG C 1 247 ? -11.834 -13.323 13.215  1.00 49.79  ?  241 ARG C CD  1 
ATOM   6078 N NE  . ARG C 1 247 ? -11.290 -12.084 13.752  1.00 52.69  ?  241 ARG C NE  1 
ATOM   6079 C CZ  . ARG C 1 247 ? -11.911 -11.303 14.634  1.00 58.24  ?  241 ARG C CZ  1 
ATOM   6080 N NH1 . ARG C 1 247 ? -13.062 -11.650 15.171  1.00 43.02  ?  241 ARG C NH1 1 
ATOM   6081 N NH2 . ARG C 1 247 ? -11.367 -10.129 14.974  1.00 57.43  ?  241 ARG C NH2 1 
ATOM   6082 N N   . LYS C 1 248 ? -15.129 -12.329 9.742   1.00 49.40  ?  242 LYS C N   1 
ATOM   6083 C CA  . LYS C 1 248 ? -14.659 -11.566 8.603   1.00 51.04  ?  242 LYS C CA  1 
ATOM   6084 C C   . LYS C 1 248 ? -13.762 -10.476 9.165   1.00 55.25  ?  242 LYS C C   1 
ATOM   6085 O O   . LYS C 1 248 ? -14.174 -9.737  10.066  1.00 53.69  ?  242 LYS C O   1 
ATOM   6086 C CB  . LYS C 1 248 ? -15.832 -11.003 7.803   1.00 50.90  ?  242 LYS C CB  1 
ATOM   6087 C CG  . LYS C 1 248 ? -15.432 -10.083 6.655   1.00 55.12  ?  242 LYS C CG  1 
ATOM   6088 C CD  . LYS C 1 248 ? -16.683 -9.672  5.910   1.00 52.30  ?  242 LYS C CD  1 
ATOM   6089 C CE  . LYS C 1 248 ? -16.822 -8.184  5.899   1.00 59.89  ?  242 LYS C CE  1 
ATOM   6090 N NZ  . LYS C 1 248 ? -17.424 -7.603  7.119   1.00 61.79  ?  242 LYS C NZ  1 
ATOM   6091 N N   . GLY C 1 249 ? -12.520 -10.423 8.694   1.00 52.84  ?  243 GLY C N   1 
ATOM   6092 C CA  . GLY C 1 249 ? -11.558 -9.578  9.368   1.00 47.49  ?  243 GLY C CA  1 
ATOM   6093 C C   . GLY C 1 249 ? -10.398 -9.243  8.464   1.00 51.94  ?  243 GLY C C   1 
ATOM   6094 O O   . GLY C 1 249 ? -10.334 -9.689  7.317   1.00 49.35  ?  243 GLY C O   1 
ATOM   6095 N N   . VAL C 1 250 ? -9.479  -8.424  8.989   1.00 54.65  ?  244 VAL C N   1 
ATOM   6096 C CA  . VAL C 1 250 ? -8.297  -8.006  8.240   1.00 54.03  ?  244 VAL C CA  1 
ATOM   6097 C C   . VAL C 1 250 ? -7.081  -8.740  8.796   1.00 52.78  ?  244 VAL C C   1 
ATOM   6098 O O   . VAL C 1 250 ? -6.922  -8.882  10.013  1.00 55.34  ?  244 VAL C O   1 
ATOM   6099 C CB  . VAL C 1 250 ? -8.109  -6.470  8.240   1.00 59.19  ?  244 VAL C CB  1 
ATOM   6100 C CG1 . VAL C 1 250 ? -9.169  -5.763  9.055   1.00 52.26  ?  244 VAL C CG1 1 
ATOM   6101 C CG2 . VAL C 1 250 ? -6.694  -6.052  8.648   1.00 54.84  ?  244 VAL C CG2 1 
ATOM   6102 N N   . SER C 1 251 ? -6.267  -9.270  7.902   1.00 54.51  ?  245 SER C N   1 
ATOM   6103 C CA  . SER C 1 251 ? -5.001  -9.891  8.267   1.00 52.79  ?  245 SER C CA  1 
ATOM   6104 C C   . SER C 1 251 ? -3.917  -8.881  7.944   1.00 52.90  ?  245 SER C C   1 
ATOM   6105 O O   . SER C 1 251 ? -3.783  -8.473  6.787   1.00 51.47  ?  245 SER C O   1 
ATOM   6106 C CB  . SER C 1 251 ? -4.774  -11.192 7.500   1.00 53.54  ?  245 SER C CB  1 
ATOM   6107 O OG  . SER C 1 251 ? -5.862  -12.096 7.668   1.00 56.05  ?  245 SER C OG  1 
ATOM   6108 N N   . GLY C 1 252 ? -3.168  -8.459  8.965   1.00 55.38  ?  246 GLY C N   1 
ATOM   6109 C CA  . GLY C 1 252 ? -2.168  -7.428  8.772   1.00 50.59  ?  246 GLY C CA  1 
ATOM   6110 C C   . GLY C 1 252 ? -2.868  -6.149  8.384   1.00 50.65  ?  246 GLY C C   1 
ATOM   6111 O O   . GLY C 1 252 ? -3.444  -5.476  9.241   1.00 51.56  ?  246 GLY C O   1 
ATOM   6112 N N   . GLN C 1 253 ? -2.876  -5.815  7.099   1.00 51.70  ?  247 GLN C N   1 
ATOM   6113 C CA  . GLN C 1 253 ? -3.667  -4.675  6.655   1.00 58.58  ?  247 GLN C CA  1 
ATOM   6114 C C   . GLN C 1 253 ? -4.688  -5.032  5.580   1.00 57.49  ?  247 GLN C C   1 
ATOM   6115 O O   . GLN C 1 253 ? -5.396  -4.139  5.104   1.00 59.18  ?  247 GLN C O   1 
ATOM   6116 C CB  . GLN C 1 253 ? -2.739  -3.546  6.160   1.00 61.52  ?  247 GLN C CB  1 
ATOM   6117 C CG  . GLN C 1 253 ? -2.565  -2.440  7.198   1.00 59.90  ?  247 GLN C CG  1 
ATOM   6118 C CD  . GLN C 1 253 ? -1.309  -1.594  7.016   1.00 65.32  ?  247 GLN C CD  1 
ATOM   6119 O OE1 . GLN C 1 253 ? -0.740  -1.504  5.921   1.00 63.61  ?  247 GLN C OE1 1 
ATOM   6120 N NE2 . GLN C 1 253 ? -0.874  -0.960  8.103   1.00 62.91  ?  247 GLN C NE2 1 
ATOM   6121 N N   . THR C 1 254 ? -4.803  -6.308  5.206   1.00 53.93  ?  248 THR C N   1 
ATOM   6122 C CA  . THR C 1 254 ? -5.630  -6.730  4.085   1.00 53.69  ?  248 THR C CA  1 
ATOM   6123 C C   . THR C 1 254 ? -7.033  -7.068  4.565   1.00 57.65  ?  248 THR C C   1 
ATOM   6124 O O   . THR C 1 254 ? -7.204  -8.035  5.322   1.00 57.15  ?  248 THR C O   1 
ATOM   6125 C CB  . THR C 1 254 ? -5.018  -7.953  3.417   1.00 54.10  ?  248 THR C CB  1 
ATOM   6126 O OG1 . THR C 1 254 ? -3.716  -7.621  2.904   1.00 56.54  ?  248 THR C OG1 1 
ATOM   6127 C CG2 . THR C 1 254 ? -5.933  -8.463  2.300   1.00 45.01  ?  248 THR C CG2 1 
ATOM   6128 N N   . GLN C 1 255 ? -8.027  -6.308  4.084   1.00 52.70  ?  249 GLN C N   1 
ATOM   6129 C CA  . GLN C 1 255 ? -9.455  -6.483  4.388   1.00 56.09  ?  249 GLN C CA  1 
ATOM   6130 C C   . GLN C 1 255 ? -10.053 -7.761  3.787   1.00 57.75  ?  249 GLN C C   1 
ATOM   6131 O O   . GLN C 1 255 ? -9.519  -8.363  2.847   1.00 53.29  ?  249 GLN C O   1 
ATOM   6132 C CB  . GLN C 1 255 ? -10.274 -5.307  3.841   1.00 54.10  ?  249 GLN C CB  1 
ATOM   6133 C CG  . GLN C 1 255 ? -9.593  -3.935  3.989   1.00 56.93  ?  249 GLN C CG  1 
ATOM   6134 C CD  . GLN C 1 255 ? -9.483  -3.536  5.445   1.00 54.35  ?  249 GLN C CD  1 
ATOM   6135 O OE1 . GLN C 1 255 ? -8.375  -3.488  6.010   1.00 48.95  ?  249 GLN C OE1 1 
ATOM   6136 N NE2 . GLN C 1 255 ? -10.638 -3.299  6.084   1.00 45.40  ?  249 GLN C NE2 1 
ATOM   6137 N N   . ASN C 1 256 ? -11.217 -8.142  4.330   1.00 55.81  ?  250 ASN C N   1 
ATOM   6138 C CA  . ASN C 1 256 ? -12.099 -9.145  3.729   1.00 54.80  ?  250 ASN C CA  1 
ATOM   6139 C C   . ASN C 1 256 ? -11.502 -10.558 3.784   1.00 56.26  ?  250 ASN C C   1 
ATOM   6140 O O   . ASN C 1 256 ? -11.587 -11.331 2.822   1.00 55.14  ?  250 ASN C O   1 
ATOM   6141 C CB  . ASN C 1 256 ? -12.467 -8.771  2.291   1.00 50.40  ?  250 ASN C CB  1 
ATOM   6142 C CG  . ASN C 1 256 ? -13.708 -9.498  1.813   1.00 56.02  ?  250 ASN C CG  1 
ATOM   6143 O OD1 . ASN C 1 256 ? -14.636 -9.710  2.593   1.00 58.53  ?  250 ASN C OD1 1 
ATOM   6144 N ND2 . ASN C 1 256 ? -13.727 -9.899  0.540   1.00 51.57  ?  250 ASN C ND2 1 
ATOM   6145 N N   . GLN C 1 257 ? -10.904 -10.909 4.913   1.00 56.09  ?  251 GLN C N   1 
ATOM   6146 C CA  . GLN C 1 257 ? -10.477 -12.280 5.162   1.00 52.12  ?  251 GLN C CA  1 
ATOM   6147 C C   . GLN C 1 257 ? -11.650 -13.059 5.750   1.00 53.95  ?  251 GLN C C   1 
ATOM   6148 O O   . GLN C 1 257 ? -12.222 -12.647 6.769   1.00 50.29  ?  251 GLN C O   1 
ATOM   6149 C CB  . GLN C 1 257 ? -9.272  -12.288 6.098   1.00 55.81  ?  251 GLN C CB  1 
ATOM   6150 C CG  . GLN C 1 257 ? -8.063  -11.501 5.570   1.00 51.71  ?  251 GLN C CG  1 
ATOM   6151 C CD  . GLN C 1 257 ? -7.490  -12.091 4.289   1.00 56.51  ?  251 GLN C CD  1 
ATOM   6152 O OE1 . GLN C 1 257 ? -8.115  -12.012 3.237   1.00 60.41  ?  251 GLN C OE1 1 
ATOM   6153 N NE2 . GLN C 1 257 ? -6.299  -12.697 4.375   1.00 55.67  ?  251 GLN C NE2 1 
ATOM   6154 N N   . LEU C 1 258 ? -12.018 -14.171 5.103   1.00 51.98  ?  252 LEU C N   1 
ATOM   6155 C CA  . LEU C 1 258 ? -13.234 -14.912 5.430   1.00 52.84  ?  252 LEU C CA  1 
ATOM   6156 C C   . LEU C 1 258 ? -12.896 -16.282 6.025   1.00 55.69  ?  252 LEU C C   1 
ATOM   6157 O O   . LEU C 1 258 ? -12.238 -17.102 5.372   1.00 55.40  ?  252 LEU C O   1 
ATOM   6158 C CB  . LEU C 1 258 ? -14.099 -15.066 4.179   1.00 53.98  ?  252 LEU C CB  1 
ATOM   6159 C CG  . LEU C 1 258 ? -14.377 -13.737 3.476   1.00 56.37  ?  252 LEU C CG  1 
ATOM   6160 C CD1 . LEU C 1 258 ? -14.977 -13.940 2.075   1.00 50.69  ?  252 LEU C CD1 1 
ATOM   6161 C CD2 . LEU C 1 258 ? -15.270 -12.861 4.361   1.00 49.75  ?  252 LEU C CD2 1 
ATOM   6162 N N   . PHE C 1 259 ? -13.376 -16.538 7.245   1.00 52.94  ?  253 PHE C N   1 
ATOM   6163 C CA  . PHE C 1 259 ? -13.210 -17.827 7.913   1.00 55.19  ?  253 PHE C CA  1 
ATOM   6164 C C   . PHE C 1 259 ? -14.559 -18.340 8.389   1.00 57.35  ?  253 PHE C C   1 
ATOM   6165 O O   . PHE C 1 259 ? -15.325 -17.585 8.999   1.00 57.23  ?  253 PHE C O   1 
ATOM   6166 C CB  . PHE C 1 259 ? -12.271 -17.720 9.113   1.00 52.67  ?  253 PHE C CB  1 
ATOM   6167 C CG  . PHE C 1 259 ? -11.094 -16.831 8.876   1.00 57.65  ?  253 PHE C CG  1 
ATOM   6168 C CD1 . PHE C 1 259 ? -11.190 -15.460 9.066   1.00 57.34  ?  253 PHE C CD1 1 
ATOM   6169 C CD2 . PHE C 1 259 ? -9.894  -17.359 8.461   1.00 54.72  ?  253 PHE C CD2 1 
ATOM   6170 C CE1 . PHE C 1 259 ? -10.100 -14.644 8.849   1.00 54.46  ?  253 PHE C CE1 1 
ATOM   6171 C CE2 . PHE C 1 259 ? -8.800  -16.550 8.238   1.00 57.54  ?  253 PHE C CE2 1 
ATOM   6172 C CZ  . PHE C 1 259 ? -8.902  -15.197 8.427   1.00 56.61  ?  253 PHE C CZ  1 
ATOM   6173 N N   . THR C 1 260 ? -14.841 -19.622 8.129   1.00 55.87  ?  254 THR C N   1 
ATOM   6174 C CA  . THR C 1 260 ? -16.072 -20.263 8.593   1.00 59.59  ?  254 THR C CA  1 
ATOM   6175 C C   . THR C 1 260 ? -15.735 -21.643 9.124   1.00 55.57  ?  254 THR C C   1 
ATOM   6176 O O   . THR C 1 260 ? -15.042 -22.412 8.453   1.00 56.57  ?  254 THR C O   1 
ATOM   6177 C CB  . THR C 1 260 ? -17.125 -20.394 7.480   1.00 55.95  ?  254 THR C CB  1 
ATOM   6178 O OG1 . THR C 1 260 ? -16.563 -21.141 6.412   1.00 66.81  ?  254 THR C OG1 1 
ATOM   6179 C CG2 . THR C 1 260 ? -17.528 -19.044 6.928   1.00 63.55  ?  254 THR C CG2 1 
ATOM   6180 N N   . TYR C 1 261 ? -16.221 -21.947 10.324  1.00 55.44  ?  255 TYR C N   1 
ATOM   6181 C CA  . TYR C 1 261 ? -16.029 -23.238 10.965  1.00 52.31  ?  255 TYR C CA  1 
ATOM   6182 C C   . TYR C 1 261 ? -17.392 -23.820 11.341  1.00 57.01  ?  255 TYR C C   1 
ATOM   6183 O O   . TYR C 1 261 ? -18.187 -23.174 12.041  1.00 55.45  ?  255 TYR C O   1 
ATOM   6184 C CB  . TYR C 1 261 ? -15.145 -23.117 12.203  1.00 52.02  ?  255 TYR C CB  1 
ATOM   6185 C CG  . TYR C 1 261 ? -15.130 -24.412 13.010  1.00 61.65  ?  255 TYR C CG  1 
ATOM   6186 C CD1 . TYR C 1 261 ? -14.352 -25.498 12.597  1.00 62.62  ?  255 TYR C CD1 1 
ATOM   6187 C CD2 . TYR C 1 261 ? -15.915 -24.564 14.160  1.00 56.07  ?  255 TYR C CD2 1 
ATOM   6188 C CE1 . TYR C 1 261 ? -14.336 -26.688 13.311  1.00 64.83  ?  255 TYR C CE1 1 
ATOM   6189 C CE2 . TYR C 1 261 ? -15.924 -25.750 14.869  1.00 59.69  ?  255 TYR C CE2 1 
ATOM   6190 C CZ  . TYR C 1 261 ? -15.123 -26.809 14.446  1.00 65.56  ?  255 TYR C CZ  1 
ATOM   6191 O OH  . TYR C 1 261 ? -15.084 -27.992 15.150  1.00 61.34  ?  255 TYR C OH  1 
ATOM   6192 N N   . GLU C 1 262 ? -17.658 -25.040 10.888  1.00 54.72  ?  256 GLU C N   1 
ATOM   6193 C CA  . GLU C 1 262 ? -18.981 -25.630 11.044  1.00 61.15  ?  256 GLU C CA  1 
ATOM   6194 C C   . GLU C 1 262 ? -18.890 -27.080 11.487  1.00 59.68  ?  256 GLU C C   1 
ATOM   6195 O O   . GLU C 1 262 ? -18.051 -27.847 10.996  1.00 60.38  ?  256 GLU C O   1 
ATOM   6196 C CB  . GLU C 1 262 ? -19.778 -25.556 9.747   1.00 58.85  ?  256 GLU C CB  1 
ATOM   6197 C CG  . GLU C 1 262 ? -20.844 -24.524 9.845   1.00 72.00  ?  256 GLU C CG  1 
ATOM   6198 C CD  . GLU C 1 262 ? -21.818 -24.580 8.699   1.00 82.46  ?  256 GLU C CD  1 
ATOM   6199 O OE1 . GLU C 1 262 ? -21.376 -24.390 7.541   1.00 79.51  ?  256 GLU C OE1 1 
ATOM   6200 O OE2 . GLU C 1 262 ? -23.024 -24.807 8.973   1.00 85.92  -1 256 GLU C OE2 1 
ATOM   6201 N N   . MET C 1 263 ? -19.760 -27.454 12.418  1.00 52.87  ?  257 MET C N   1 
ATOM   6202 C CA  . MET C 1 263 ? -19.813 -28.847 12.814  1.00 57.47  ?  257 MET C CA  1 
ATOM   6203 C C   . MET C 1 263 ? -21.232 -29.244 13.215  1.00 56.76  ?  257 MET C C   1 
ATOM   6204 O O   . MET C 1 263 ? -21.939 -28.490 13.892  1.00 55.15  ?  257 MET C O   1 
ATOM   6205 C CB  . MET C 1 263 ? -18.807 -29.119 13.939  1.00 57.90  ?  257 MET C CB  1 
ATOM   6206 C CG  . MET C 1 263 ? -19.063 -28.393 15.218  1.00 57.62  ?  257 MET C CG  1 
ATOM   6207 S SD  . MET C 1 263 ? -17.812 -28.844 16.462  1.00 66.96  ?  257 MET C SD  1 
ATOM   6208 C CE  . MET C 1 263 ? -18.484 -27.820 17.788  1.00 56.60  ?  257 MET C CE  1 
ATOM   6209 N N   . ARG C 1 264 ? -21.640 -30.426 12.748  1.00 54.36  ?  258 ARG C N   1 
ATOM   6210 C CA  . ARG C 1 264 ? -22.896 -31.080 13.112  1.00 55.89  ?  258 ARG C CA  1 
ATOM   6211 C C   . ARG C 1 264 ? -22.529 -32.340 13.890  1.00 53.49  ?  258 ARG C C   1 
ATOM   6212 O O   . ARG C 1 264 ? -22.011 -33.296 13.311  1.00 52.91  ?  258 ARG C O   1 
ATOM   6213 C CB  . ARG C 1 264 ? -23.722 -31.432 11.872  1.00 57.55  ?  258 ARG C CB  1 
ATOM   6214 C CG  . ARG C 1 264 ? -24.034 -30.273 10.914  1.00 62.97  ?  258 ARG C CG  1 
ATOM   6215 C CD  . ARG C 1 264 ? -23.651 -30.661 9.469   1.00 71.03  ?  258 ARG C CD  1 
ATOM   6216 N NE  . ARG C 1 264 ? -22.183 -30.713 9.375   1.00 80.21  ?  258 ARG C NE  1 
ATOM   6217 C CZ  . ARG C 1 264 ? -21.405 -29.755 8.884   1.00 62.04  ?  258 ARG C CZ  1 
ATOM   6218 N NH1 . ARG C 1 264 ? -21.918 -28.650 8.363   1.00 70.03  ?  258 ARG C NH1 1 
ATOM   6219 N NH2 . ARG C 1 264 ? -20.091 -29.911 8.922   1.00 40.09  ?  258 ARG C NH2 1 
ATOM   6220 N N   . ILE C 1 265 ? -22.783 -32.350 15.198  1.00 49.14  ?  259 ILE C N   1 
ATOM   6221 C CA  . ILE C 1 265 ? -22.223 -33.379 16.061  1.00 52.53  ?  259 ILE C CA  1 
ATOM   6222 C C   . ILE C 1 265 ? -23.209 -33.782 17.148  1.00 54.85  ?  259 ILE C C   1 
ATOM   6223 O O   . ILE C 1 265 ? -24.175 -33.076 17.450  1.00 57.81  ?  259 ILE C O   1 
ATOM   6224 C CB  . ILE C 1 265 ? -20.878 -32.923 16.702  1.00 59.16  ?  259 ILE C CB  1 
ATOM   6225 C CG1 . ILE C 1 265 ? -21.002 -31.535 17.330  1.00 58.17  ?  259 ILE C CG1 1 
ATOM   6226 C CG2 . ILE C 1 265 ? -19.749 -32.875 15.655  1.00 54.64  ?  259 ILE C CG2 1 
ATOM   6227 C CD1 . ILE C 1 265 ? -21.326 -31.570 18.775  1.00 58.30  ?  259 ILE C CD1 1 
ATOM   6228 N N   . ASN C 1 266 ? -22.955 -34.953 17.726  1.00 56.15  ?  260 ASN C N   1 
ATOM   6229 C CA  . ASN C 1 266 ? -23.584 -35.353 18.981  1.00 57.14  ?  260 ASN C CA  1 
ATOM   6230 C C   . ASN C 1 266 ? -22.850 -34.613 20.107  1.00 60.28  ?  260 ASN C C   1 
ATOM   6231 O O   . ASN C 1 266 ? -21.668 -34.879 20.388  1.00 56.32  ?  260 ASN C O   1 
ATOM   6232 C CB  . ASN C 1 266 ? -23.529 -36.875 19.117  1.00 51.37  ?  260 ASN C CB  1 
ATOM   6233 C CG  . ASN C 1 266 ? -24.141 -37.397 20.419  1.00 54.83  ?  260 ASN C CG  1 
ATOM   6234 O OD1 . ASN C 1 266 ? -23.870 -36.893 21.504  1.00 58.23  ?  260 ASN C OD1 1 
ATOM   6235 N ND2 . ASN C 1 266 ? -24.936 -38.452 20.310  1.00 54.92  ?  260 ASN C ND2 1 
ATOM   6236 N N   . ASN C 1 267 ? -23.550 -33.677 20.745  1.00 58.63  ?  261 ASN C N   1 
ATOM   6237 C CA  . ASN C 1 267 ? -22.889 -32.763 21.672  1.00 60.13  ?  261 ASN C CA  1 
ATOM   6238 C C   . ASN C 1 267 ? -22.263 -33.490 22.849  1.00 60.68  ?  261 ASN C C   1 
ATOM   6239 O O   . ASN C 1 267 ? -21.063 -33.280 23.099  1.00 59.43  ?  261 ASN C O   1 
ATOM   6240 C CB  . ASN C 1 267 ? -23.884 -31.683 22.131  1.00 58.16  ?  261 ASN C CB  1 
ATOM   6241 C CG  . ASN C 1 267 ? -23.220 -30.502 22.876  1.00 61.55  ?  261 ASN C CG  1 
ATOM   6242 O OD1 . ASN C 1 267 ? -23.877 -29.531 23.202  1.00 72.70  ?  261 ASN C OD1 1 
ATOM   6243 N ND2 . ASN C 1 267 ? -21.926 -30.595 23.139  1.00 64.05  ?  261 ASN C ND2 1 
ATOM   6244 N N   . PRO C 1 268 ? -22.979 -34.323 23.610  1.00 63.51  ?  262 PRO C N   1 
ATOM   6245 C CA  . PRO C 1 268 ? -22.327 -34.964 24.766  1.00 58.62  ?  262 PRO C CA  1 
ATOM   6246 C C   . PRO C 1 268 ? -21.230 -35.924 24.364  1.00 54.38  ?  262 PRO C C   1 
ATOM   6247 O O   . PRO C 1 268 ? -20.262 -36.103 25.114  1.00 54.85  ?  262 PRO C O   1 
ATOM   6248 C CB  . PRO C 1 268 ? -23.486 -35.678 25.480  1.00 60.03  ?  262 PRO C CB  1 
ATOM   6249 C CG  . PRO C 1 268 ? -24.557 -35.827 24.432  1.00 57.95  ?  262 PRO C CG  1 
ATOM   6250 C CD  . PRO C 1 268 ? -24.424 -34.619 23.550  1.00 55.30  ?  262 PRO C CD  1 
ATOM   6251 N N   . ALA C 1 269 ? -21.335 -36.559 23.205  1.00 57.22  ?  263 ALA C N   1 
ATOM   6252 C CA  . ALA C 1 269 ? -20.217 -37.400 22.796  1.00 58.89  ?  263 ALA C CA  1 
ATOM   6253 C C   . ALA C 1 269 ? -18.978 -36.548 22.514  1.00 59.54  ?  263 ALA C C   1 
ATOM   6254 O O   . ALA C 1 269 ? -17.863 -36.933 22.872  1.00 58.48  ?  263 ALA C O   1 
ATOM   6255 C CB  . ALA C 1 269 ? -20.598 -38.250 21.586  1.00 51.81  ?  263 ALA C CB  1 
ATOM   6256 N N   . LEU C 1 270 ? -19.155 -35.369 21.906  1.00 54.25  ?  264 LEU C N   1 
ATOM   6257 C CA  . LEU C 1 270 ? -17.999 -34.545 21.596  1.00 52.06  ?  264 LEU C CA  1 
ATOM   6258 C C   . LEU C 1 270 ? -17.412 -33.958 22.867  1.00 56.61  ?  264 LEU C C   1 
ATOM   6259 O O   . LEU C 1 270 ? -16.189 -33.993 23.062  1.00 54.33  ?  264 LEU C O   1 
ATOM   6260 C CB  . LEU C 1 270 ? -18.365 -33.450 20.600  1.00 53.77  ?  264 LEU C CB  1 
ATOM   6261 C CG  . LEU C 1 270 ? -17.246 -32.484 20.211  1.00 56.95  ?  264 LEU C CG  1 
ATOM   6262 C CD1 . LEU C 1 270 ? -15.972 -33.220 19.855  1.00 51.85  ?  264 LEU C CD1 1 
ATOM   6263 C CD2 . LEU C 1 270 ? -17.681 -31.599 19.044  1.00 59.99  ?  264 LEU C CD2 1 
ATOM   6264 N N   . THR C 1 271 ? -18.270 -33.482 23.774  1.00 56.93  ?  265 THR C N   1 
ATOM   6265 C CA  . THR C 1 271 ? -17.774 -32.932 25.030  1.00 57.76  ?  265 THR C CA  1 
ATOM   6266 C C   . THR C 1 271 ? -17.017 -33.992 25.842  1.00 61.49  ?  265 THR C C   1 
ATOM   6267 O O   . THR C 1 271 ? -15.916 -33.740 26.341  1.00 63.01  ?  265 THR C O   1 
ATOM   6268 C CB  . THR C 1 271 ? -18.923 -32.335 25.831  1.00 53.82  ?  265 THR C CB  1 
ATOM   6269 O OG1 . THR C 1 271 ? -19.280 -31.069 25.260  1.00 59.02  ?  265 THR C OG1 1 
ATOM   6270 C CG2 . THR C 1 271 ? -18.502 -32.102 27.265  1.00 57.54  ?  265 THR C CG2 1 
ATOM   6271 N N   . SER C 1 272 ? -17.571 -35.193 25.967  1.00 59.67  ?  266 SER C N   1 
ATOM   6272 C CA  . SER C 1 272 ? -16.856 -36.209 26.722  1.00 58.59  ?  266 SER C CA  1 
ATOM   6273 C C   . SER C 1 272 ? -15.556 -36.566 26.030  1.00 58.09  ?  266 SER C C   1 
ATOM   6274 O O   . SER C 1 272 ? -14.537 -36.820 26.691  1.00 56.72  ?  266 SER C O   1 
ATOM   6275 C CB  . SER C 1 272 ? -17.724 -37.449 26.911  1.00 54.45  ?  266 SER C CB  1 
ATOM   6276 O OG  . SER C 1 272 ? -18.378 -37.782 25.701  1.00 61.36  ?  266 SER C OG  1 
ATOM   6277 N N   . GLN C 1 273 ? -15.554 -36.576 24.697  1.00 53.42  ?  267 GLN C N   1 
ATOM   6278 C CA  . GLN C 1 273 ? -14.306 -36.895 24.013  1.00 56.38  ?  267 GLN C CA  1 
ATOM   6279 C C   . GLN C 1 273 ? -13.257 -35.792 24.225  1.00 57.41  ?  267 GLN C C   1 
ATOM   6280 O O   . GLN C 1 273 ? -12.073 -36.084 24.418  1.00 53.98  ?  267 GLN C O   1 
ATOM   6281 C CB  . GLN C 1 273 ? -14.556 -37.120 22.529  1.00 54.27  ?  267 GLN C CB  1 
ATOM   6282 C CG  . GLN C 1 273 ? -13.250 -37.164 21.732  1.00 56.53  ?  267 GLN C CG  1 
ATOM   6283 C CD  . GLN C 1 273 ? -12.502 -38.434 21.995  1.00 57.13  ?  267 GLN C CD  1 
ATOM   6284 O OE1 . GLN C 1 273 ? -12.618 -39.394 21.249  1.00 59.49  ?  267 GLN C OE1 1 
ATOM   6285 N NE2 . GLN C 1 273 ? -11.769 -38.470 23.094  1.00 58.98  ?  267 GLN C NE2 1 
ATOM   6286 N N   . VAL C 1 274 ? -13.685 -34.521 24.222  1.00 53.86  ?  268 VAL C N   1 
ATOM   6287 C CA  . VAL C 1 274 ? -12.778 -33.411 24.474  1.00 51.50  ?  268 VAL C CA  1 
ATOM   6288 C C   . VAL C 1 274 ? -12.242 -33.462 25.902  1.00 58.29  ?  268 VAL C C   1 
ATOM   6289 O O   . VAL C 1 274 ? -11.061 -33.162 26.146  1.00 58.77  ?  268 VAL C O   1 
ATOM   6290 C CB  . VAL C 1 274 ? -13.482 -32.076 24.169  1.00 58.97  ?  268 VAL C CB  1 
ATOM   6291 C CG1 . VAL C 1 274 ? -12.701 -30.868 24.778  1.00 58.82  ?  268 VAL C CG1 1 
ATOM   6292 C CG2 . VAL C 1 274 ? -13.678 -31.918 22.658  1.00 52.56  ?  268 VAL C CG2 1 
ATOM   6293 N N   . MET C 1 275 ? -13.078 -33.844 26.872  1.00 54.02  ?  269 MET C N   1 
ATOM   6294 C CA  . MET C 1 275 ? -12.549 -33.973 28.232  1.00 58.67  ?  269 MET C CA  1 
ATOM   6295 C C   . MET C 1 275 ? -11.522 -35.096 28.348  1.00 57.97  ?  269 MET C C   1 
ATOM   6296 O O   . MET C 1 275 ? -10.545 -34.970 29.098  1.00 61.38  ?  269 MET C O   1 
ATOM   6297 C CB  . MET C 1 275 ? -13.660 -34.177 29.262  1.00 55.77  ?  269 MET C CB  1 
ATOM   6298 C CG  . MET C 1 275 ? -14.682 -33.089 29.331  1.00 59.81  ?  269 MET C CG  1 
ATOM   6299 S SD  . MET C 1 275 ? -16.081 -33.589 30.349  1.00 68.12  ?  269 MET C SD  1 
ATOM   6300 C CE  . MET C 1 275 ? -15.407 -33.060 31.909  1.00 66.48  ?  269 MET C CE  1 
ATOM   6301 N N   . ILE C 1 276 ? -11.722 -36.195 27.620  1.00 54.30  ?  270 ILE C N   1 
ATOM   6302 C CA  . ILE C 1 276 ? -10.796 -37.318 27.712  1.00 51.72  ?  270 ILE C CA  1 
ATOM   6303 C C   . ILE C 1 276 ? -9.455  -36.952 27.094  1.00 51.87  ?  270 ILE C C   1 
ATOM   6304 O O   . ILE C 1 276 ? -8.402  -37.325 27.618  1.00 53.76  ?  270 ILE C O   1 
ATOM   6305 C CB  . ILE C 1 276 ? -11.410 -38.580 27.065  1.00 54.75  ?  270 ILE C CB  1 
ATOM   6306 C CG1 . ILE C 1 276 ? -12.060 -39.474 28.133  1.00 51.78  ?  270 ILE C CG1 1 
ATOM   6307 C CG2 . ILE C 1 276 ? -10.372 -39.371 26.309  1.00 56.57  ?  270 ILE C CG2 1 
ATOM   6308 C CD1 . ILE C 1 276 ? -13.221 -38.799 28.878  1.00 44.55  ?  270 ILE C CD1 1 
ATOM   6309 N N   . ALA C 1 277 ? -9.465  -36.211 25.977  1.00 52.08  ?  271 ALA C N   1 
ATOM   6310 C CA  . ALA C 1 277 ? -8.218  -35.697 25.413  1.00 53.18  ?  271 ALA C CA  1 
ATOM   6311 C C   . ALA C 1 277 ? -7.551  -34.728 26.374  1.00 56.39  ?  271 ALA C C   1 
ATOM   6312 O O   . ALA C 1 277 ? -6.320  -34.741 26.521  1.00 59.10  ?  271 ALA C O   1 
ATOM   6313 C CB  . ALA C 1 277 ? -8.459  -35.019 24.064  1.00 52.47  ?  271 ALA C CB  1 
ATOM   6314 N N   . SER C 1 278 ? -8.343  -33.907 27.065  1.00 50.33  ?  272 SER C N   1 
ATOM   6315 C CA  . SER C 1 278 ? -7.762  -33.031 28.077  1.00 55.85  ?  272 SER C CA  1 
ATOM   6316 C C   . SER C 1 278 ? -7.138  -33.826 29.217  1.00 60.78  ?  272 SER C C   1 
ATOM   6317 O O   . SER C 1 278 ? -6.202  -33.345 29.867  1.00 58.22  ?  272 SER C O   1 
ATOM   6318 C CB  . SER C 1 278 ? -8.824  -32.078 28.624  1.00 58.30  ?  272 SER C CB  1 
ATOM   6319 O OG  . SER C 1 278 ? -9.275  -31.173 27.629  1.00 61.06  ?  272 SER C OG  1 
ATOM   6320 N N   . ALA C 1 279 ? -7.659  -35.027 29.502  1.00 59.81  ?  273 ALA C N   1 
ATOM   6321 C CA  . ALA C 1 279 ? -7.067  -35.832 30.565  1.00 61.13  ?  273 ALA C CA  1 
ATOM   6322 C C   . ALA C 1 279 ? -5.649  -36.227 30.198  1.00 64.14  ?  273 ALA C C   1 
ATOM   6323 O O   . ALA C 1 279 ? -4.736  -36.142 31.028  1.00 66.42  ?  273 ALA C O   1 
ATOM   6324 C CB  . ALA C 1 279 ? -7.906  -37.075 30.845  1.00 57.48  ?  273 ALA C CB  1 
ATOM   6325 N N   . ARG C 1 280 ? -5.453  -36.675 28.957  1.00 59.29  ?  274 ARG C N   1 
ATOM   6326 C CA  . ARG C 1 280 ? -4.112  -36.958 28.463  1.00 58.57  ?  274 ARG C CA  1 
ATOM   6327 C C   . ARG C 1 280 ? -3.217  -35.731 28.566  1.00 61.30  ?  274 ARG C C   1 
ATOM   6328 O O   . ARG C 1 280 ? -2.071  -35.828 29.026  1.00 63.98  ?  274 ARG C O   1 
ATOM   6329 C CB  . ARG C 1 280 ? -4.230  -37.468 27.039  1.00 55.48  ?  274 ARG C CB  1 
ATOM   6330 C CG  . ARG C 1 280 ? -3.117  -37.209 26.133  1.00 58.33  ?  274 ARG C CG  1 
ATOM   6331 C CD  . ARG C 1 280 ? -3.428  -37.838 24.751  1.00 60.80  ?  274 ARG C CD  1 
ATOM   6332 N NE  . ARG C 1 280 ? -4.401  -38.916 24.861  1.00 63.90  ?  274 ARG C NE  1 
ATOM   6333 C CZ  . ARG C 1 280 ? -5.515  -39.028 24.144  1.00 62.79  ?  274 ARG C CZ  1 
ATOM   6334 N NH1 . ARG C 1 280 ? -5.926  -38.055 23.339  1.00 62.09  ?  274 ARG C NH1 1 
ATOM   6335 N NH2 . ARG C 1 280 ? -6.247  -40.146 24.242  1.00 59.55  ?  274 ARG C NH2 1 
ATOM   6336 N N   . ALA C 1 281 ? -3.743  -34.560 28.201  1.00 55.47  ?  275 ALA C N   1 
ATOM   6337 C CA  . ALA C 1 281 ? -2.947  -33.340 28.239  1.00 59.18  ?  275 ALA C CA  1 
ATOM   6338 C C   . ALA C 1 281 ? -2.622  -32.927 29.665  1.00 61.76  ?  275 ALA C C   1 
ATOM   6339 O O   . ALA C 1 281 ? -1.539  -32.390 29.912  1.00 57.64  ?  275 ALA C O   1 
ATOM   6340 C CB  . ALA C 1 281 ? -3.664  -32.191 27.516  1.00 53.23  ?  275 ALA C CB  1 
ATOM   6341 N N   . ALA C 1 282 ? -3.536  -33.164 30.611  1.00 63.06  ?  276 ALA C N   1 
ATOM   6342 C CA  . ALA C 1 282 ? -3.284  -32.740 31.987  1.00 64.48  ?  276 ALA C CA  1 
ATOM   6343 C C   . ALA C 1 282 ? -2.071  -33.450 32.569  1.00 67.18  ?  276 ALA C C   1 
ATOM   6344 O O   . ALA C 1 282 ? -1.382  -32.901 33.435  1.00 64.09  ?  276 ALA C O   1 
ATOM   6345 C CB  . ALA C 1 282 ? -4.514  -32.994 32.860  1.00 62.97  ?  276 ALA C CB  1 
ATOM   6346 N N   . MET C 1 283 ? -1.782  -34.661 32.100  1.00 60.70  ?  277 MET C N   1 
ATOM   6347 C CA  . MET C 1 283 ? -0.584  -35.327 32.573  1.00 61.76  ?  277 MET C CA  1 
ATOM   6348 C C   . MET C 1 283 ? 0.698   -34.655 32.093  1.00 66.47  ?  277 MET C C   1 
ATOM   6349 O O   . MET C 1 283 ? 1.760   -34.910 32.663  1.00 67.79  ?  277 MET C O   1 
ATOM   6350 C CB  . MET C 1 283 ? -0.607  -36.785 32.138  1.00 61.18  ?  277 MET C CB  1 
ATOM   6351 C CG  . MET C 1 283 ? -1.846  -37.491 32.612  1.00 67.67  ?  277 MET C CG  1 
ATOM   6352 S SD  . MET C 1 283 ? -1.805  -37.928 34.364  1.00 70.49  ?  277 MET C SD  1 
ATOM   6353 C CE  . MET C 1 283 ? -0.612  -39.262 34.305  1.00 61.36  ?  277 MET C CE  1 
ATOM   6354 N N   . ARG C 1 284 ? 0.637   -33.808 31.066  1.00 63.40  ?  278 ARG C N   1 
ATOM   6355 C CA  . ARG C 1 284 ? 1.841   -33.249 30.469  1.00 62.88  ?  278 ARG C CA  1 
ATOM   6356 C C   . ARG C 1 284 ? 2.073   -31.809 30.888  1.00 64.02  ?  278 ARG C C   1 
ATOM   6357 O O   . ARG C 1 284 ? 2.836   -31.093 30.230  1.00 70.84  ?  278 ARG C O   1 
ATOM   6358 C CB  . ARG C 1 284 ? 1.789   -33.356 28.940  1.00 59.44  ?  278 ARG C CB  1 
ATOM   6359 C CG  . ARG C 1 284 ? 1.567   -34.774 28.399  1.00 52.41  ?  278 ARG C CG  1 
ATOM   6360 C CD  . ARG C 1 284 ? 1.017   -34.761 26.972  1.00 50.99  ?  278 ARG C CD  1 
ATOM   6361 N NE  . ARG C 1 284 ? 1.507   -35.885 26.173  1.00 61.68  ?  278 ARG C NE  1 
ATOM   6362 C CZ  . ARG C 1 284 ? 0.817   -36.507 25.220  1.00 61.45  ?  278 ARG C CZ  1 
ATOM   6363 N NH1 . ARG C 1 284 ? -0.413  -36.146 24.907  1.00 62.42  ?  278 ARG C NH1 1 
ATOM   6364 N NH2 . ARG C 1 284 ? 1.384   -37.506 24.547  1.00 63.04  ?  278 ARG C NH2 1 
ATOM   6365 N N   . GLN C 1 285 ? 1.456   -31.375 31.978  1.00 62.52  ?  279 GLN C N   1 
ATOM   6366 C CA  . GLN C 1 285 ? 1.521   -29.987 32.403  1.00 62.92  ?  279 GLN C CA  1 
ATOM   6367 C C   . GLN C 1 285 ? 2.207   -29.886 33.760  1.00 68.31  ?  279 GLN C C   1 
ATOM   6368 O O   . GLN C 1 285 ? 2.478   -30.888 34.429  1.00 72.36  ?  279 GLN C O   1 
ATOM   6369 C CB  . GLN C 1 285 ? 0.117   -29.362 32.477  1.00 63.10  ?  279 GLN C CB  1 
ATOM   6370 C CG  . GLN C 1 285 ? -0.709  -29.455 31.188  1.00 61.07  ?  279 GLN C CG  1 
ATOM   6371 C CD  . GLN C 1 285 ? 0.068   -29.028 29.942  1.00 60.14  ?  279 GLN C CD  1 
ATOM   6372 O OE1 . GLN C 1 285 ? 0.594   -27.900 29.860  1.00 57.10  ?  279 GLN C OE1 1 
ATOM   6373 N NE2 . GLN C 1 285 ? 0.133   -29.921 28.964  1.00 48.51  ?  279 GLN C NE2 1 
ATOM   6374 N N   . LYS C 1 286 ? 2.494   -28.661 34.149  1.00 67.95  ?  280 LYS C N   1 
ATOM   6375 C CA  . LYS C 1 286 ? 2.968   -28.335 35.480  1.00 67.85  ?  280 LYS C CA  1 
ATOM   6376 C C   . LYS C 1 286 ? 1.777   -28.076 36.375  1.00 67.49  ?  280 LYS C C   1 
ATOM   6377 O O   . LYS C 1 286 ? 0.680   -27.803 35.886  1.00 68.88  ?  280 LYS C O   1 
ATOM   6378 C CB  . LYS C 1 286 ? 3.875   -27.099 35.439  1.00 67.61  ?  280 LYS C CB  1 
ATOM   6379 C CG  . LYS C 1 286 ? 5.258   -27.399 34.898  1.00 72.06  ?  280 LYS C CG  1 
ATOM   6380 C CD  . LYS C 1 286 ? 6.282   -26.345 35.284  1.00 79.68  ?  280 LYS C CD  1 
ATOM   6381 C CE  . LYS C 1 286 ? 6.685   -25.524 34.074  1.00 78.01  ?  280 LYS C CE  1 
ATOM   6382 N NZ  . LYS C 1 286 ? 6.675   -26.359 32.840  1.00 78.16  ?  280 LYS C NZ  1 
ATOM   6383 N N   . PRO C 1 287 ? 1.938   -28.211 37.689  1.00 70.09  ?  281 PRO C N   1 
ATOM   6384 C CA  . PRO C 1 287 ? 0.834   -27.883 38.586  1.00 66.48  ?  281 PRO C CA  1 
ATOM   6385 C C   . PRO C 1 287 ? 0.286   -26.508 38.248  1.00 66.78  ?  281 PRO C C   1 
ATOM   6386 O O   . PRO C 1 287 ? 1.020   -25.626 37.796  1.00 64.29  ?  281 PRO C O   1 
ATOM   6387 C CB  . PRO C 1 287 ? 1.483   -27.930 39.970  1.00 65.34  ?  281 PRO C CB  1 
ATOM   6388 C CG  . PRO C 1 287 ? 2.529   -28.991 39.815  1.00 65.87  ?  281 PRO C CG  1 
ATOM   6389 C CD  . PRO C 1 287 ? 3.019   -28.927 38.393  1.00 66.55  ?  281 PRO C CD  1 
ATOM   6390 N N   . GLY C 1 288 ? -1.028  -26.361 38.417  1.00 65.62  ?  282 GLY C N   1 
ATOM   6391 C CA  . GLY C 1 288 ? -1.763  -25.184 38.015  1.00 62.79  ?  282 GLY C CA  1 
ATOM   6392 C C   . GLY C 1 288 ? -3.032  -25.557 37.283  1.00 69.48  ?  282 GLY C C   1 
ATOM   6393 O O   . GLY C 1 288 ? -3.338  -26.727 37.060  1.00 68.85  ?  282 GLY C O   1 
ATOM   6394 N N   . ALA C 1 289 ? -3.784  -24.526 36.904  1.00 67.73  ?  283 ALA C N   1 
ATOM   6395 C CA  . ALA C 1 289 ? -5.077  -24.695 36.260  1.00 66.59  ?  283 ALA C CA  1 
ATOM   6396 C C   . ALA C 1 289 ? -5.082  -23.964 34.922  1.00 66.94  ?  283 ALA C C   1 
ATOM   6397 O O   . ALA C 1 289 ? -4.710  -22.789 34.852  1.00 69.61  ?  283 ALA C O   1 
ATOM   6398 C CB  . ALA C 1 289 ? -6.211  -24.197 37.161  1.00 62.43  ?  283 ALA C CB  1 
ATOM   6399 N N   . TYR C 1 290 ? -5.536  -24.649 33.873  1.00 62.92  ?  284 TYR C N   1 
ATOM   6400 C CA  . TYR C 1 290 ? -5.472  -24.147 32.511  1.00 60.97  ?  284 TYR C CA  1 
ATOM   6401 C C   . TYR C 1 290 ? -6.833  -24.279 31.848  1.00 59.63  ?  284 TYR C C   1 
ATOM   6402 O O   . TYR C 1 290 ? -7.561  -25.240 32.104  1.00 62.00  ?  284 TYR C O   1 
ATOM   6403 C CB  . TYR C 1 290 ? -4.437  -24.919 31.662  1.00 57.32  ?  284 TYR C CB  1 
ATOM   6404 C CG  . TYR C 1 290 ? -3.095  -25.169 32.315  1.00 61.07  ?  284 TYR C CG  1 
ATOM   6405 C CD1 . TYR C 1 290 ? -2.956  -26.045 33.387  1.00 61.04  ?  284 TYR C CD1 1 
ATOM   6406 C CD2 . TYR C 1 290 ? -1.946  -24.557 31.825  1.00 64.72  ?  284 TYR C CD2 1 
ATOM   6407 C CE1 . TYR C 1 290 ? -1.720  -26.282 33.968  1.00 63.28  ?  284 TYR C CE1 1 
ATOM   6408 C CE2 . TYR C 1 290 ? -0.704  -24.791 32.400  1.00 62.65  ?  284 TYR C CE2 1 
ATOM   6409 C CZ  . TYR C 1 290 ? -0.596  -25.648 33.474  1.00 63.74  ?  284 TYR C CZ  1 
ATOM   6410 O OH  . TYR C 1 290 ? 0.646   -25.860 34.036  1.00 64.65  ?  284 TYR C OH  1 
ATOM   6411 N N   . THR C 1 291 ? -7.166  -23.307 31.000  1.00 59.20  ?  285 THR C N   1 
ATOM   6412 C CA  . THR C 1 291 ? -8.170  -23.433 29.952  1.00 56.26  ?  285 THR C CA  1 
ATOM   6413 C C   . THR C 1 291 ? -7.517  -23.981 28.685  1.00 53.67  ?  285 THR C C   1 
ATOM   6414 O O   . THR C 1 291 ? -6.296  -24.048 28.572  1.00 58.43  ?  285 THR C O   1 
ATOM   6415 C CB  . THR C 1 291 ? -8.817  -22.081 29.642  1.00 53.76  ?  285 THR C CB  1 
ATOM   6416 O OG1 . THR C 1 291 ? -7.843  -21.239 29.018  1.00 56.92  ?  285 THR C OG1 1 
ATOM   6417 C CG2 . THR C 1 291 ? -9.354  -21.423 30.894  1.00 51.47  ?  285 THR C CG2 1 
ATOM   6418 N N   . MET C 1 292 ? -8.334  -24.341 27.703  1.00 51.00  ?  286 MET C N   1 
ATOM   6419 C CA  . MET C 1 292 ? -7.759  -25.033 26.558  1.00 51.15  ?  286 MET C CA  1 
ATOM   6420 C C   . MET C 1 292 ? -6.973  -24.133 25.607  1.00 54.30  ?  286 MET C C   1 
ATOM   6421 O O   . MET C 1 292 ? -6.327  -24.661 24.698  1.00 59.48  ?  286 MET C O   1 
ATOM   6422 C CB  . MET C 1 292 ? -8.818  -25.799 25.753  1.00 54.37  ?  286 MET C CB  1 
ATOM   6423 C CG  . MET C 1 292 ? -9.854  -26.660 26.507  1.00 60.78  ?  286 MET C CG  1 
ATOM   6424 S SD  . MET C 1 292 ? -10.772 -27.742 25.328  1.00 58.93  ?  286 MET C SD  1 
ATOM   6425 C CE  . MET C 1 292 ? -9.438  -28.828 24.749  1.00 57.66  ?  286 MET C CE  1 
ATOM   6426 N N   . ILE C 1 293 ? -7.014  -22.805 25.753  1.00 50.53  ?  287 ILE C N   1 
ATOM   6427 C CA  . ILE C 1 293 ? -6.132  -21.953 24.953  1.00 54.63  ?  287 ILE C CA  1 
ATOM   6428 C C   . ILE C 1 293 ? -4.775  -21.742 25.615  1.00 56.35  ?  287 ILE C C   1 
ATOM   6429 O O   . ILE C 1 293 ? -3.927  -21.030 25.058  1.00 55.12  ?  287 ILE C O   1 
ATOM   6430 C CB  . ILE C 1 293 ? -6.744  -20.573 24.644  1.00 55.17  ?  287 ILE C CB  1 
ATOM   6431 C CG1 . ILE C 1 293 ? -7.071  -19.830 25.944  1.00 50.09  ?  287 ILE C CG1 1 
ATOM   6432 C CG2 . ILE C 1 293 ? -7.964  -20.716 23.717  1.00 51.40  ?  287 ILE C CG2 1 
ATOM   6433 C CD1 . ILE C 1 293 ? -7.583  -18.464 25.701  1.00 48.77  ?  287 ILE C CD1 1 
ATOM   6434 N N   . GLU C 1 294 ? -4.540  -22.352 26.777  1.00 53.37  ?  288 GLU C N   1 
ATOM   6435 C CA  . GLU C 1 294 ? -3.273  -22.264 27.491  1.00 56.22  ?  288 GLU C CA  1 
ATOM   6436 C C   . GLU C 1 294 ? -2.467  -23.557 27.407  1.00 56.34  ?  288 GLU C C   1 
ATOM   6437 O O   . GLU C 1 294 ? -1.526  -23.744 28.182  1.00 56.26  ?  288 GLU C O   1 
ATOM   6438 C CB  . GLU C 1 294 ? -3.517  -21.897 28.957  1.00 52.89  ?  288 GLU C CB  1 
ATOM   6439 C CG  . GLU C 1 294 ? -4.215  -20.582 29.125  1.00 54.73  ?  288 GLU C CG  1 
ATOM   6440 C CD  . GLU C 1 294 ? -4.807  -20.417 30.506  1.00 63.79  ?  288 GLU C CD  1 
ATOM   6441 O OE1 . GLU C 1 294 ? -4.042  -20.081 31.443  1.00 59.90  ?  288 GLU C OE1 1 
ATOM   6442 O OE2 . GLU C 1 294 ? -6.041  -20.626 30.650  1.00 64.29  -1 288 GLU C OE2 1 
ATOM   6443 N N   . ILE C 1 295 ? -2.822  -24.453 26.489  1.00 56.61  ?  289 ILE C N   1 
ATOM   6444 C CA  . ILE C 1 295 ? -2.145  -25.739 26.374  1.00 51.99  ?  289 ILE C CA  1 
ATOM   6445 C C   . ILE C 1 295 ? -1.773  -26.023 24.922  1.00 52.40  ?  289 ILE C C   1 
ATOM   6446 O O   . ILE C 1 295 ? -2.601  -25.839 24.025  1.00 55.69  ?  289 ILE C O   1 
ATOM   6447 C CB  . ILE C 1 295 ? -3.031  -26.846 26.967  1.00 57.11  ?  289 ILE C CB  1 
ATOM   6448 C CG1 . ILE C 1 295 ? -3.067  -26.675 28.483  1.00 54.53  ?  289 ILE C CG1 1 
ATOM   6449 C CG2 . ILE C 1 295 ? -2.578  -28.260 26.539  1.00 51.80  ?  289 ILE C CG2 1 
ATOM   6450 C CD1 . ILE C 1 295 ? -3.513  -27.865 29.184  1.00 57.97  ?  289 ILE C CD1 1 
ATOM   6451 N N   . PRO C 1 296 ? -0.561  -26.488 24.638  1.00 56.41  ?  290 PRO C N   1 
ATOM   6452 C CA  . PRO C 1 296 ? -0.223  -26.846 23.251  1.00 57.32  ?  290 PRO C CA  1 
ATOM   6453 C C   . PRO C 1 296 ? -1.195  -27.884 22.706  1.00 56.79  ?  290 PRO C C   1 
ATOM   6454 O O   . PRO C 1 296 ? -1.474  -28.891 23.355  1.00 57.20  ?  290 PRO C O   1 
ATOM   6455 C CB  . PRO C 1 296 ? 1.200   -27.413 23.365  1.00 55.40  ?  290 PRO C CB  1 
ATOM   6456 C CG  . PRO C 1 296 ? 1.743   -26.837 24.645  1.00 53.63  ?  290 PRO C CG  1 
ATOM   6457 C CD  . PRO C 1 296 ? 0.543   -26.780 25.565  1.00 56.40  ?  290 PRO C CD  1 
ATOM   6458 N N   . ILE C 1 297 ? -1.696  -27.630 21.494  1.00 53.19  ?  291 ILE C N   1 
ATOM   6459 C CA  . ILE C 1 297 ? -2.641  -28.533 20.849  1.00 50.37  ?  291 ILE C CA  1 
ATOM   6460 C C   . ILE C 1 297 ? -2.085  -29.958 20.779  1.00 55.44  ?  291 ILE C C   1 
ATOM   6461 O O   . ILE C 1 297 ? -2.826  -30.936 20.925  1.00 49.96  ?  291 ILE C O   1 
ATOM   6462 C CB  . ILE C 1 297 ? -3.008  -27.990 19.456  1.00 50.28  ?  291 ILE C CB  1 
ATOM   6463 C CG1 . ILE C 1 297 ? -3.847  -26.714 19.577  1.00 50.58  ?  291 ILE C CG1 1 
ATOM   6464 C CG2 . ILE C 1 297 ? -3.769  -29.032 18.627  1.00 49.82  ?  291 ILE C CG2 1 
ATOM   6465 C CD1 . ILE C 1 297 ? -4.035  -25.979 18.248  1.00 48.80  ?  291 ILE C CD1 1 
ATOM   6466 N N   . ILE C 1 298 ? -0.773  -30.106 20.587  1.00 57.84  ?  292 ILE C N   1 
ATOM   6467 C CA  . ILE C 1 298 ? -0.217  -31.456 20.482  1.00 56.52  ?  292 ILE C CA  1 
ATOM   6468 C C   . ILE C 1 298 ? -0.374  -32.208 21.802  1.00 55.93  ?  292 ILE C C   1 
ATOM   6469 O O   . ILE C 1 298 ? -0.461  -33.442 21.806  1.00 58.72  ?  292 ILE C O   1 
ATOM   6470 C CB  . ILE C 1 298 ? 1.262   -31.429 20.015  1.00 53.17  ?  292 ILE C CB  1 
ATOM   6471 C CG1 . ILE C 1 298 ? 1.758   -32.840 19.727  1.00 54.83  ?  292 ILE C CG1 1 
ATOM   6472 C CG2 . ILE C 1 298 ? 2.179   -30.867 21.073  1.00 52.15  ?  292 ILE C CG2 1 
ATOM   6473 C CD1 . ILE C 1 298 ? 2.537   -32.952 18.472  1.00 56.22  ?  292 ILE C CD1 1 
ATOM   6474 N N   . ASP C 1 299 ? -0.447  -31.499 22.935  1.00 51.27  ?  293 ASP C N   1 
ATOM   6475 C CA  . ASP C 1 299 ? -0.572  -32.197 24.216  1.00 55.65  ?  293 ASP C CA  1 
ATOM   6476 C C   . ASP C 1 299 ? -1.879  -32.984 24.341  1.00 57.11  ?  293 ASP C C   1 
ATOM   6477 O O   . ASP C 1 299 ? -1.940  -33.931 25.131  1.00 56.52  ?  293 ASP C O   1 
ATOM   6478 C CB  . ASP C 1 299 ? -0.425  -31.210 25.385  1.00 53.14  ?  293 ASP C CB  1 
ATOM   6479 C CG  . ASP C 1 299 ? 1.050   -30.781 25.610  1.00 59.90  ?  293 ASP C CG  1 
ATOM   6480 O OD1 . ASP C 1 299 ? 1.924   -31.222 24.827  1.00 65.15  ?  293 ASP C OD1 1 
ATOM   6481 O OD2 . ASP C 1 299 ? 1.342   -29.990 26.531  1.00 60.81  -1 293 ASP C OD2 1 
ATOM   6482 N N   . PHE C 1 300 ? -2.913  -32.640 23.574  1.00 53.39  ?  294 PHE C N   1 
ATOM   6483 C CA  . PHE C 1 300 ? -4.163  -33.395 23.625  1.00 57.40  ?  294 PHE C CA  1 
ATOM   6484 C C   . PHE C 1 300 ? -4.130  -34.681 22.797  1.00 60.24  ?  294 PHE C C   1 
ATOM   6485 O O   . PHE C 1 300 ? -5.070  -35.477 22.865  1.00 53.78  ?  294 PHE C O   1 
ATOM   6486 C CB  . PHE C 1 300 ? -5.330  -32.521 23.145  1.00 52.60  ?  294 PHE C CB  1 
ATOM   6487 C CG  . PHE C 1 300 ? -5.568  -31.311 24.006  1.00 54.77  ?  294 PHE C CG  1 
ATOM   6488 C CD1 . PHE C 1 300 ? -6.374  -31.397 25.132  1.00 49.70  ?  294 PHE C CD1 1 
ATOM   6489 C CD2 . PHE C 1 300 ? -4.972  -30.098 23.698  1.00 50.90  ?  294 PHE C CD2 1 
ATOM   6490 C CE1 . PHE C 1 300 ? -6.588  -30.311 25.931  1.00 50.05  ?  294 PHE C CE1 1 
ATOM   6491 C CE2 . PHE C 1 300 ? -5.193  -28.993 24.492  1.00 57.12  ?  294 PHE C CE2 1 
ATOM   6492 C CZ  . PHE C 1 300 ? -6.002  -29.099 25.617  1.00 54.85  ?  294 PHE C CZ  1 
ATOM   6493 N N   . LEU C 1 301 ? -3.098  -34.910 22.006  1.00 59.78  ?  295 LEU C N   1 
ATOM   6494 C CA  . LEU C 1 301 ? -3.141  -36.002 21.051  1.00 60.38  ?  295 LEU C CA  1 
ATOM   6495 C C   . LEU C 1 301 ? -2.411  -37.218 21.604  1.00 61.69  ?  295 LEU C C   1 
ATOM   6496 O O   . LEU C 1 301 ? -1.355  -37.096 22.241  1.00 58.32  ?  295 LEU C O   1 
ATOM   6497 C CB  . LEU C 1 301 ? -2.534  -35.574 19.719  1.00 57.82  ?  295 LEU C CB  1 
ATOM   6498 C CG  . LEU C 1 301 ? -3.325  -34.451 19.047  1.00 58.78  ?  295 LEU C CG  1 
ATOM   6499 C CD1 . LEU C 1 301 ? -2.396  -33.656 18.104  1.00 60.55  ?  295 LEU C CD1 1 
ATOM   6500 C CD2 . LEU C 1 301 ? -4.526  -35.010 18.293  1.00 50.34  ?  295 LEU C CD2 1 
ATOM   6501 N N   . TYR C 1 302 ? -2.997  -38.387 21.383  1.00 61.77  ?  296 TYR C N   1 
ATOM   6502 C CA  . TYR C 1 302 ? -2.306  -39.624 21.679  1.00 56.41  ?  296 TYR C CA  1 
ATOM   6503 C C   . TYR C 1 302 ? -1.314  -39.894 20.555  1.00 58.90  ?  296 TYR C C   1 
ATOM   6504 O O   . TYR C 1 302 ? -1.644  -39.765 19.373  1.00 61.89  ?  296 TYR C O   1 
ATOM   6505 C CB  . TYR C 1 302 ? -3.300  -40.780 21.839  1.00 61.29  ?  296 TYR C CB  1 
ATOM   6506 C CG  . TYR C 1 302 ? -2.639  -42.141 21.822  1.00 68.32  ?  296 TYR C CG  1 
ATOM   6507 C CD1 . TYR C 1 302 ? -1.932  -42.606 22.928  1.00 68.01  ?  296 TYR C CD1 1 
ATOM   6508 C CD2 . TYR C 1 302 ? -2.679  -42.946 20.680  1.00 67.78  ?  296 TYR C CD2 1 
ATOM   6509 C CE1 . TYR C 1 302 ? -1.293  -43.845 22.899  1.00 69.73  ?  296 TYR C CE1 1 
ATOM   6510 C CE2 . TYR C 1 302 ? -2.055  -44.191 20.646  1.00 64.21  ?  296 TYR C CE2 1 
ATOM   6511 C CZ  . TYR C 1 302 ? -1.360  -44.635 21.756  1.00 70.61  ?  296 TYR C CZ  1 
ATOM   6512 O OH  . TYR C 1 302 ? -0.720  -45.867 21.732  1.00 73.08  ?  296 TYR C OH  1 
ATOM   6513 N N   . GLY C 1 303 ? -0.087  -40.235 20.921  1.00 59.85  ?  297 GLY C N   1 
ATOM   6514 C CA  . GLY C 1 303 ? 0.853   -40.656 19.910  1.00 60.78  ?  297 GLY C CA  1 
ATOM   6515 C C   . GLY C 1 303 ? 2.268   -40.162 20.111  1.00 63.34  ?  297 GLY C C   1 
ATOM   6516 O O   . GLY C 1 303 ? 2.571   -39.356 21.001  1.00 62.06  ?  297 GLY C O   1 
ATOM   6517 N N   . ASP C 1 304 ? 3.148   -40.646 19.257  1.00 61.50  ?  298 ASP C N   1 
ATOM   6518 C CA  . ASP C 1 304 ? 4.524   -40.192 19.262  1.00 67.16  ?  298 ASP C CA  1 
ATOM   6519 C C   . ASP C 1 304 ? 4.600   -38.786 18.645  1.00 65.38  ?  298 ASP C C   1 
ATOM   6520 O O   . ASP C 1 304 ? 4.162   -38.577 17.505  1.00 62.56  ?  298 ASP C O   1 
ATOM   6521 C CB  . ASP C 1 304 ? 5.377   -41.206 18.508  1.00 52.53  ?  298 ASP C CB  1 
ATOM   6522 C CG  . ASP C 1 304 ? 6.705   -40.634 18.067  1.00 68.04  ?  298 ASP C CG  1 
ATOM   6523 O OD1 . ASP C 1 304 ? 7.631   -40.512 18.909  1.00 71.69  ?  298 ASP C OD1 1 
ATOM   6524 O OD2 . ASP C 1 304 ? 6.820   -40.305 16.867  1.00 69.54  -1 298 ASP C OD2 1 
ATOM   6525 N N   . ARG C 1 305 ? 5.148   -37.829 19.402  1.00 57.76  ?  299 ARG C N   1 
ATOM   6526 C CA  . ARG C 1 305 ? 5.241   -36.431 18.981  1.00 63.10  ?  299 ARG C CA  1 
ATOM   6527 C C   . ARG C 1 305 ? 5.683   -36.271 17.523  1.00 64.18  ?  299 ARG C C   1 
ATOM   6528 O O   . ARG C 1 305 ? 4.988   -35.633 16.718  1.00 61.24  ?  299 ARG C O   1 
ATOM   6529 C CB  . ARG C 1 305 ? 6.201   -35.677 19.924  1.00 63.36  ?  299 ARG C CB  1 
ATOM   6530 C CG  . ARG C 1 305 ? 6.232   -34.157 19.762  1.00 74.38  ?  299 ARG C CG  1 
ATOM   6531 C CD  . ARG C 1 305 ? 7.146   -33.434 20.824  1.00 83.90  ?  299 ARG C CD  1 
ATOM   6532 N NE  . ARG C 1 305 ? 6.373   -32.858 21.930  1.00 75.06  ?  299 ARG C NE  1 
ATOM   6533 C CZ  . ARG C 1 305 ? 6.011   -31.586 22.020  1.00 72.03  ?  299 ARG C CZ  1 
ATOM   6534 N NH1 . ARG C 1 305 ? 6.392   -30.695 21.121  1.00 73.59  ?  299 ARG C NH1 1 
ATOM   6535 N NH2 . ARG C 1 305 ? 5.230   -31.198 23.029  1.00 78.57  ?  299 ARG C NH2 1 
ATOM   6536 N N   . ASP C 1 306 ? 6.837   -36.850 17.161  1.00 63.88  ?  300 ASP C N   1 
ATOM   6537 C CA  . ASP C 1 306 ? 7.338   -36.691 15.797  1.00 64.82  ?  300 ASP C CA  1 
ATOM   6538 C C   . ASP C 1 306 ? 6.369   -37.272 14.772  1.00 65.52  ?  300 ASP C C   1 
ATOM   6539 O O   . ASP C 1 306 ? 6.205   -36.718 13.681  1.00 67.74  ?  300 ASP C O   1 
ATOM   6540 C CB  . ASP C 1 306 ? 8.716   -37.340 15.635  1.00 62.78  ?  300 ASP C CB  1 
ATOM   6541 C CG  . ASP C 1 306 ? 9.873   -36.402 16.016  1.00 66.32  ?  300 ASP C CG  1 
ATOM   6542 O OD1 . ASP C 1 306 ? 9.627   -35.283 16.538  1.00 68.41  ?  300 ASP C OD1 1 
ATOM   6543 O OD2 . ASP C 1 306 ? 11.040  -36.801 15.804  1.00 66.67  -1 300 ASP C OD2 1 
ATOM   6544 N N   . GLU C 1 307 ? 5.717   -38.385 15.082  1.00 61.46  ?  301 GLU C N   1 
ATOM   6545 C CA  . GLU C 1 307 ? 4.869   -38.928 14.032  1.00 65.49  ?  301 GLU C CA  1 
ATOM   6546 C C   . GLU C 1 307 ? 3.563   -38.149 13.926  1.00 65.70  ?  301 GLU C C   1 
ATOM   6547 O O   . GLU C 1 307 ? 2.993   -38.051 12.829  1.00 63.60  ?  301 GLU C O   1 
ATOM   6548 C CB  . GLU C 1 307 ? 4.619   -40.429 14.249  1.00 65.38  ?  301 GLU C CB  1 
ATOM   6549 C CG  . GLU C 1 307 ? 3.603   -41.027 13.260  1.00 71.71  ?  301 GLU C CG  1 
ATOM   6550 C CD  . GLU C 1 307 ? 3.981   -40.805 11.770  1.00 81.40  ?  301 GLU C CD  1 
ATOM   6551 O OE1 . GLU C 1 307 ? 5.155   -41.022 11.372  1.00 81.40  ?  301 GLU C OE1 1 
ATOM   6552 O OE2 . GLU C 1 307 ? 3.088   -40.366 10.997  1.00 85.66  -1 301 GLU C OE2 1 
ATOM   6553 N N   . LEU C 1 308 ? 3.081   -37.601 15.050  1.00 61.24  ?  302 LEU C N   1 
ATOM   6554 C CA  . LEU C 1 308 ? 1.973   -36.650 15.010  1.00 62.00  ?  302 LEU C CA  1 
ATOM   6555 C C   . LEU C 1 308 ? 2.319   -35.458 14.130  1.00 61.16  ?  302 LEU C C   1 
ATOM   6556 O O   . LEU C 1 308 ? 1.494   -35.006 13.326  1.00 56.57  ?  302 LEU C O   1 
ATOM   6557 C CB  . LEU C 1 308 ? 1.632   -36.176 16.424  1.00 60.15  ?  302 LEU C CB  1 
ATOM   6558 C CG  . LEU C 1 308 ? 1.064   -37.193 17.422  1.00 58.54  ?  302 LEU C CG  1 
ATOM   6559 C CD1 . LEU C 1 308 ? 1.194   -36.646 18.845  1.00 54.64  ?  302 LEU C CD1 1 
ATOM   6560 C CD2 . LEU C 1 308 ? -0.396  -37.557 17.081  1.00 57.49  ?  302 LEU C CD2 1 
ATOM   6561 N N   . ILE C 1 309 ? 3.546   -34.943 14.267  1.00 59.56  ?  303 ILE C N   1 
ATOM   6562 C CA  . ILE C 1 309 ? 3.975   -33.809 13.459  1.00 60.57  ?  303 ILE C CA  1 
ATOM   6563 C C   . ILE C 1 309 ? 3.997   -34.198 11.987  1.00 59.80  ?  303 ILE C C   1 
ATOM   6564 O O   . ILE C 1 309 ? 3.327   -33.581 11.151  1.00 61.92  ?  303 ILE C O   1 
ATOM   6565 C CB  . ILE C 1 309 ? 5.340   -33.298 13.943  1.00 53.50  ?  303 ILE C CB  1 
ATOM   6566 C CG1 . ILE C 1 309 ? 5.152   -32.536 15.240  1.00 53.79  ?  303 ILE C CG1 1 
ATOM   6567 C CG2 . ILE C 1 309 ? 5.980   -32.382 12.923  1.00 54.36  ?  303 ILE C CG2 1 
ATOM   6568 C CD1 . ILE C 1 309 ? 6.445   -32.132 15.880  1.00 58.30  ?  303 ILE C CD1 1 
ATOM   6569 N N   . ARG C 1 310 ? 4.773   -35.229 11.662  1.00 56.63  ?  304 ARG C N   1 
ATOM   6570 C CA  . ARG C 1 310 ? 4.804   -35.799 10.318  1.00 62.51  ?  304 ARG C CA  1 
ATOM   6571 C C   . ARG C 1 310 ? 3.401   -35.992 9.735   1.00 63.06  ?  304 ARG C C   1 
ATOM   6572 O O   . ARG C 1 310 ? 3.191   -35.803 8.533   1.00 69.26  ?  304 ARG C O   1 
ATOM   6573 C CB  . ARG C 1 310 ? 5.559   -37.134 10.369  1.00 67.34  ?  304 ARG C CB  1 
ATOM   6574 C CG  . ARG C 1 310 ? 5.935   -37.745 9.050   1.00 67.12  ?  304 ARG C CG  1 
ATOM   6575 C CD  . ARG C 1 310 ? 7.350   -38.368 9.106   1.00 79.75  ?  304 ARG C CD  1 
ATOM   6576 N NE  . ARG C 1 310 ? 7.844   -38.685 10.449  1.00 80.06  ?  304 ARG C NE  1 
ATOM   6577 C CZ  . ARG C 1 310 ? 9.134   -38.694 10.781  1.00 78.86  ?  304 ARG C CZ  1 
ATOM   6578 N NH1 . ARG C 1 310 ? 10.077  -38.413 9.898   1.00 81.01  ?  304 ARG C NH1 1 
ATOM   6579 N NH2 . ARG C 1 310 ? 9.488   -38.981 12.031  1.00 75.17  ?  304 ARG C NH2 1 
ATOM   6580 N N   . ARG C 1 311 ? 2.423   -36.351 10.567  1.00 62.99  ?  305 ARG C N   1 
ATOM   6581 C CA  . ARG C 1 311 ? 1.084   -36.654 10.065  1.00 59.65  ?  305 ARG C CA  1 
ATOM   6582 C C   . ARG C 1 311 ? 0.221   -35.414 9.900   1.00 66.75  ?  305 ARG C C   1 
ATOM   6583 O O   . ARG C 1 311 ? -0.565  -35.335 8.949   1.00 70.32  ?  305 ARG C O   1 
ATOM   6584 C CB  . ARG C 1 311 ? 0.361   -37.629 10.996  1.00 64.16  ?  305 ARG C CB  1 
ATOM   6585 C CG  . ARG C 1 311 ? -0.982  -38.136 10.446  1.00 71.92  ?  305 ARG C CG  1 
ATOM   6586 C CD  . ARG C 1 311 ? -2.020  -38.406 11.543  1.00 70.83  ?  305 ARG C CD  1 
ATOM   6587 N NE  . ARG C 1 311 ? -1.502  -39.261 12.608  1.00 72.26  ?  305 ARG C NE  1 
ATOM   6588 C CZ  . ARG C 1 311 ? -2.095  -39.435 13.784  1.00 71.37  ?  305 ARG C CZ  1 
ATOM   6589 N NH1 . ARG C 1 311 ? -3.257  -38.867 14.064  1.00 65.61  ?  305 ARG C NH1 1 
ATOM   6590 N NH2 . ARG C 1 311 ? -1.501  -40.193 14.708  1.00 71.16  ?  305 ARG C NH2 1 
ATOM   6591 N N   . LEU C 1 312 ? 0.332   -34.454 10.818  1.00 58.95  ?  306 LEU C N   1 
ATOM   6592 C CA  . LEU C 1 312 ? -0.637  -33.377 10.925  1.00 58.20  ?  306 LEU C CA  1 
ATOM   6593 C C   . LEU C 1 312 ? -0.129  -32.039 10.407  1.00 61.88  ?  306 LEU C C   1 
ATOM   6594 O O   . LEU C 1 312 ? -0.870  -31.334 9.709   1.00 60.00  ?  306 LEU C O   1 
ATOM   6595 C CB  . LEU C 1 312 ? -1.074  -33.222 12.386  1.00 56.51  ?  306 LEU C CB  1 
ATOM   6596 C CG  . LEU C 1 312 ? -1.879  -34.378 12.982  1.00 60.17  ?  306 LEU C CG  1 
ATOM   6597 C CD1 . LEU C 1 312 ? -1.741  -34.456 14.500  1.00 55.26  ?  306 LEU C CD1 1 
ATOM   6598 C CD2 . LEU C 1 312 ? -3.335  -34.215 12.602  1.00 58.46  ?  306 LEU C CD2 1 
ATOM   6599 N N   . VAL C 1 313 ? 1.111   -31.666 10.722  1.00 56.43  ?  307 VAL C N   1 
ATOM   6600 C CA  . VAL C 1 313 ? 1.565   -30.311 10.469  1.00 54.87  ?  307 VAL C CA  1 
ATOM   6601 C C   . VAL C 1 313 ? 1.681   -30.029 8.967   1.00 62.40  ?  307 VAL C C   1 
ATOM   6602 O O   . VAL C 1 313 ? 0.918   -29.234 8.405   1.00 64.37  ?  307 VAL C O   1 
ATOM   6603 C CB  . VAL C 1 313 ? 2.892   -30.034 11.159  1.00 56.69  ?  307 VAL C CB  1 
ATOM   6604 C CG1 . VAL C 1 313 ? 3.514   -28.809 10.574  1.00 52.22  ?  307 VAL C CG1 1 
ATOM   6605 C CG2 . VAL C 1 313 ? 2.706   -29.882 12.652  1.00 55.24  ?  307 VAL C CG2 1 
ATOM   6606 O OXT . VAL C 1 313 ? 2.538   -30.571 8.269   1.00 64.00  -1 307 VAL C OXT 1 
HETATM 6607 P PA  . NAP D 2 .   ? 9.100   -14.476 -3.428  1.00 65.93  ?  401 NAP A PA  1 
HETATM 6608 O O1A . NAP D 2 .   ? 8.174   -13.381 -3.840  1.00 57.60  ?  401 NAP A O1A 1 
HETATM 6609 O O2A . NAP D 2 .   ? 9.907   -15.191 -4.460  1.00 70.37  ?  401 NAP A O2A 1 
HETATM 6610 O O5B . NAP D 2 .   ? 10.059  -13.914 -2.277  1.00 65.86  ?  401 NAP A O5B 1 
HETATM 6611 C C5B . NAP D 2 .   ? 11.317  -14.555 -1.965  1.00 62.55  ?  401 NAP A C5B 1 
HETATM 6612 C C4B . NAP D 2 .   ? 12.321  -13.485 -1.618  1.00 64.09  ?  401 NAP A C4B 1 
HETATM 6613 O O4B . NAP D 2 .   ? 13.485  -14.080 -1.005  1.00 68.83  ?  401 NAP A O4B 1 
HETATM 6614 C C3B . NAP D 2 .   ? 12.898  -12.704 -2.802  1.00 67.76  ?  401 NAP A C3B 1 
HETATM 6615 O O3B . NAP D 2 .   ? 12.022  -11.626 -3.108  1.00 62.73  ?  401 NAP A O3B 1 
HETATM 6616 C C2B . NAP D 2 .   ? 14.280  -12.262 -2.318  1.00 64.29  ?  401 NAP A C2B 1 
HETATM 6617 O O2B . NAP D 2 .   ? 14.053  -10.986 -1.725  1.00 71.07  ?  401 NAP A O2B 1 
HETATM 6618 C C1B . NAP D 2 .   ? 14.598  -13.231 -1.180  1.00 64.15  ?  401 NAP A C1B 1 
HETATM 6619 N N9A . NAP D 2 .   ? 15.756  -14.101 -1.363  1.00 71.23  ?  401 NAP A N9A 1 
HETATM 6620 C C8A . NAP D 2 .   ? 16.733  -14.351 -0.429  1.00 70.88  ?  401 NAP A C8A 1 
HETATM 6621 N N7A . NAP D 2 .   ? 17.616  -15.238 -0.815  1.00 68.05  ?  401 NAP A N7A 1 
HETATM 6622 C C5A . NAP D 2 .   ? 17.175  -15.624 -2.072  1.00 68.62  ?  401 NAP A C5A 1 
HETATM 6623 C C6A . NAP D 2 .   ? 17.683  -16.555 -2.997  1.00 74.12  ?  401 NAP A C6A 1 
HETATM 6624 N N6A . NAP D 2 .   ? 18.758  -17.308 -2.767  1.00 71.61  ?  401 NAP A N6A 1 
HETATM 6625 N N1A . NAP D 2 .   ? 16.995  -16.715 -4.154  1.00 74.40  ?  401 NAP A N1A 1 
HETATM 6626 C C2A . NAP D 2 .   ? 15.900  -15.969 -4.358  1.00 72.74  ?  401 NAP A C2A 1 
HETATM 6627 N N3A . NAP D 2 .   ? 15.332  -15.066 -3.562  1.00 66.51  ?  401 NAP A N3A 1 
HETATM 6628 C C4A . NAP D 2 .   ? 16.025  -14.938 -2.420  1.00 65.42  ?  401 NAP A C4A 1 
HETATM 6629 O O3  . NAP D 2 .   ? 8.293   -15.628 -2.667  1.00 63.62  ?  401 NAP A O3  1 
HETATM 6630 P PN  . NAP D 2 .   ? 7.095   -15.514 -1.627  1.00 61.16  ?  401 NAP A PN  1 
HETATM 6631 O O1N . NAP D 2 .   ? 5.803   -15.517 -2.382  1.00 71.13  ?  401 NAP A O1N 1 
HETATM 6632 O O2N . NAP D 2 .   ? 7.376   -14.358 -0.720  1.00 67.21  ?  401 NAP A O2N 1 
HETATM 6633 O O5D . NAP D 2 .   ? 7.265   -16.876 -0.811  1.00 63.36  ?  401 NAP A O5D 1 
HETATM 6634 C C5D . NAP D 2 .   ? 8.461   -17.034 -0.016  1.00 66.63  ?  401 NAP A C5D 1 
HETATM 6635 C C4D . NAP D 2 .   ? 8.299   -18.296 0.786   1.00 63.36  ?  401 NAP A C4D 1 
HETATM 6636 O O4D . NAP D 2 .   ? 7.034   -18.242 1.467   1.00 62.06  ?  401 NAP A O4D 1 
HETATM 6637 C C3D . NAP D 2 .   ? 8.233   -19.594 -0.031  1.00 62.78  ?  401 NAP A C3D 1 
HETATM 6638 O O3D . NAP D 2 .   ? 9.515   -20.171 -0.239  1.00 72.63  ?  401 NAP A O3D 1 
HETATM 6639 C C2D . NAP D 2 .   ? 7.302   -20.474 0.814   1.00 67.54  ?  401 NAP A C2D 1 
HETATM 6640 O O2D . NAP D 2 .   ? 7.986   -21.577 1.388   1.00 69.51  ?  401 NAP A O2D 1 
HETATM 6641 C C1D . NAP D 2 .   ? 6.712   -19.561 1.896   1.00 66.97  ?  401 NAP A C1D 1 
HETATM 6642 N N1N . NAP D 2 .   ? 5.221   -19.682 1.965   1.00 65.23  ?  401 NAP A N1N 1 
HETATM 6643 C C2N . NAP D 2 .   ? 4.633   -20.455 2.941   1.00 60.23  ?  401 NAP A C2N 1 
HETATM 6644 C C3N . NAP D 2 .   ? 3.248   -20.553 3.017   1.00 62.87  ?  401 NAP A C3N 1 
HETATM 6645 C C7N . NAP D 2 .   ? 2.621   -21.482 4.028   1.00 60.03  ?  401 NAP A C7N 1 
HETATM 6646 O O7N . NAP D 2 .   ? 1.399   -21.541 4.107   1.00 62.70  ?  401 NAP A O7N 1 
HETATM 6647 N N7N . NAP D 2 .   ? 3.422   -22.212 4.793   1.00 63.69  ?  401 NAP A N7N 1 
HETATM 6648 C C4N . NAP D 2 .   ? 2.464   -19.787 2.147   1.00 64.53  ?  401 NAP A C4N 1 
HETATM 6649 C C5N . NAP D 2 .   ? 3.067   -19.010 1.182   1.00 62.24  ?  401 NAP A C5N 1 
HETATM 6650 C C6N . NAP D 2 .   ? 4.440   -19.032 1.059   1.00 61.00  ?  401 NAP A C6N 1 
HETATM 6651 P P2B . NAP D 2 .   ? 15.314  -9.980  -1.844  1.00 67.43  ?  401 NAP A P2B 1 
HETATM 6652 O O1X . NAP D 2 .   ? 16.552  -10.659 -1.313  1.00 68.17  ?  401 NAP A O1X 1 
HETATM 6653 O O2X . NAP D 2 .   ? 15.447  -9.651  -3.331  1.00 66.53  ?  401 NAP A O2X 1 
HETATM 6654 O O3X . NAP D 2 .   ? 14.889  -8.792  -0.992  1.00 59.76  ?  401 NAP A O3X 1 
HETATM 6655 P PA  . NAP E 2 .   ? 20.092  -56.723 38.236  1.00 64.81  ?  401 NAP B PA  1 
HETATM 6656 O O1A . NAP E 2 .   ? 21.151  -57.262 39.135  1.00 58.50  ?  401 NAP B O1A 1 
HETATM 6657 O O2A . NAP E 2 .   ? 19.266  -57.629 37.384  1.00 62.65  ?  401 NAP B O2A 1 
HETATM 6658 O O5B . NAP E 2 .   ? 19.133  -55.771 39.105  1.00 63.72  ?  401 NAP B O5B 1 
HETATM 6659 C C5B . NAP E 2 .   ? 17.995  -55.058 38.556  1.00 64.50  ?  401 NAP B C5B 1 
HETATM 6660 C C4B . NAP E 2 .   ? 17.062  -54.719 39.693  1.00 65.41  ?  401 NAP B C4B 1 
HETATM 6661 O O4B . NAP E 2 .   ? 15.899  -54.006 39.199  1.00 67.17  ?  401 NAP B O4B 1 
HETATM 6662 C C3B . NAP E 2 .   ? 16.500  -55.918 40.468  1.00 66.61  ?  401 NAP B C3B 1 
HETATM 6663 O O3B . NAP E 2 .   ? 17.393  -56.345 41.493  1.00 60.21  ?  401 NAP B O3B 1 
HETATM 6664 C C2B . NAP E 2 .   ? 15.151  -55.402 40.956  1.00 66.12  ?  401 NAP B C2B 1 
HETATM 6665 O O2B . NAP E 2 .   ? 15.384  -54.589 42.098  1.00 65.97  ?  401 NAP B O2B 1 
HETATM 6666 C C1B . NAP E 2 .   ? 14.723  -54.521 39.787  1.00 67.50  ?  401 NAP B C1B 1 
HETATM 6667 N N9A . NAP E 2 .   ? 13.949  -55.188 38.747  1.00 69.18  ?  401 NAP B N9A 1 
HETATM 6668 C C8A . NAP E 2 .   ? 14.230  -56.384 38.134  1.00 69.19  ?  401 NAP B C8A 1 
HETATM 6669 N N7A . NAP E 2 .   ? 13.355  -56.714 37.215  1.00 71.94  ?  401 NAP B N7A 1 
HETATM 6670 C C5A . NAP E 2 .   ? 12.451  -55.664 37.209  1.00 67.62  ?  401 NAP B C5A 1 
HETATM 6671 C C6A . NAP E 2 .   ? 11.294  -55.419 36.449  1.00 75.27  ?  401 NAP B C6A 1 
HETATM 6672 N N6A . NAP E 2 .   ? 10.846  -56.245 35.508  1.00 81.39  ?  401 NAP B N6A 1 
HETATM 6673 N N1A . NAP E 2 .   ? 10.618  -54.268 36.687  1.00 80.88  ?  401 NAP B N1A 1 
HETATM 6674 C C2A . NAP E 2 .   ? 11.081  -53.441 37.634  1.00 76.15  ?  401 NAP B C2A 1 
HETATM 6675 N N3A . NAP E 2 .   ? 12.154  -53.572 38.411  1.00 74.81  ?  401 NAP B N3A 1 
HETATM 6676 C C4A . NAP E 2 .   ? 12.806  -54.716 38.147  1.00 68.07  ?  401 NAP B C4A 1 
HETATM 6677 O O3  . NAP E 2 .   ? 20.847  -55.740 37.230  1.00 67.63  ?  401 NAP B O3  1 
HETATM 6678 P PN  . NAP E 2 .   ? 22.175  -54.896 37.475  1.00 67.18  ?  401 NAP B PN  1 
HETATM 6679 O O1N . NAP E 2 .   ? 23.401  -55.694 37.172  1.00 64.73  ?  401 NAP B O1N 1 
HETATM 6680 O O2N . NAP E 2 .   ? 22.041  -54.264 38.820  1.00 66.53  ?  401 NAP B O2N 1 
HETATM 6681 O O5D . NAP E 2 .   ? 21.976  -53.768 36.370  1.00 73.80  ?  401 NAP B O5D 1 
HETATM 6682 C C5D . NAP E 2 .   ? 21.306  -54.138 35.159  1.00 71.08  ?  401 NAP B C5D 1 
HETATM 6683 C C4D . NAP E 2 .   ? 21.134  -52.898 34.323  1.00 70.13  ?  401 NAP B C4D 1 
HETATM 6684 O O4D . NAP E 2 .   ? 22.332  -52.093 34.442  1.00 66.46  ?  401 NAP B O4D 1 
HETATM 6685 C C3D . NAP E 2 .   ? 20.911  -53.184 32.832  1.00 72.00  ?  401 NAP B C3D 1 
HETATM 6686 O O3D . NAP E 2 .   ? 19.614  -52.735 32.471  1.00 82.24  ?  401 NAP B O3D 1 
HETATM 6687 C C2D . NAP E 2 .   ? 22.042  -52.412 32.144  1.00 74.98  ?  401 NAP B C2D 1 
HETATM 6688 O O2D . NAP E 2 .   ? 21.576  -51.678 31.022  1.00 74.69  ?  401 NAP B O2D 1 
HETATM 6689 C C1D . NAP E 2 .   ? 22.677  -51.509 33.200  1.00 63.90  ?  401 NAP B C1D 1 
HETATM 6690 N N1N . NAP E 2 .   ? 24.167  -51.532 33.102  1.00 63.76  ?  401 NAP B N1N 1 
HETATM 6691 C C2N . NAP E 2 .   ? 24.812  -50.796 32.136  1.00 65.74  ?  401 NAP B C2N 1 
HETATM 6692 C C3N . NAP E 2 .   ? 26.205  -50.740 32.107  1.00 64.28  ?  401 NAP B C3N 1 
HETATM 6693 C C7N . NAP E 2 .   ? 26.861  -49.705 31.222  1.00 67.87  ?  401 NAP B C7N 1 
HETATM 6694 O O7N . NAP E 2 .   ? 26.166  -48.826 30.699  1.00 65.55  ?  401 NAP B O7N 1 
HETATM 6695 N N7N . NAP E 2 .   ? 28.174  -49.796 31.040  1.00 61.77  ?  401 NAP B N7N 1 
HETATM 6696 C C4N . NAP E 2 .   ? 26.932  -51.628 32.906  1.00 62.22  ?  401 NAP B C4N 1 
HETATM 6697 C C5N . NAP E 2 .   ? 26.279  -52.355 33.879  1.00 57.71  ?  401 NAP B C5N 1 
HETATM 6698 C C6N . NAP E 2 .   ? 24.903  -52.265 33.983  1.00 62.20  ?  401 NAP B C6N 1 
HETATM 6699 P P2B . NAP E 2 .   ? 14.190  -54.788 43.167  1.00 67.61  ?  401 NAP B P2B 1 
HETATM 6700 O O1X . NAP E 2 .   ? 12.915  -54.193 42.590  1.00 65.46  ?  401 NAP B O1X 1 
HETATM 6701 O O2X . NAP E 2 .   ? 14.685  -54.051 44.396  1.00 65.81  ?  401 NAP B O2X 1 
HETATM 6702 O O3X . NAP E 2 .   ? 14.074  -56.294 43.408  1.00 70.34  ?  401 NAP B O3X 1 
HETATM 6703 P PA  . NAP F 2 .   ? -26.669 -34.643 34.093  1.00 68.96  ?  401 NAP C PA  1 
HETATM 6704 O O1A . NAP F 2 .   ? -27.137 -35.675 33.113  1.00 62.50  ?  401 NAP C O1A 1 
HETATM 6705 O O2A . NAP F 2 .   ? -27.668 -33.937 34.952  1.00 72.66  ?  401 NAP C O2A 1 
HETATM 6706 O O5B . NAP F 2 .   ? -25.550 -35.304 35.024  1.00 68.68  ?  401 NAP C O5B 1 
HETATM 6707 C C5B . NAP F 2 .   ? -25.107 -34.688 36.261  1.00 70.26  ?  401 NAP C C5B 1 
HETATM 6708 C C4B . NAP F 2 .   ? -24.718 -35.807 37.195  1.00 72.50  ?  401 NAP C C4B 1 
HETATM 6709 O O4B . NAP F 2 .   ? -24.042 -35.300 38.371  1.00 74.09  ?  401 NAP C O4B 1 
HETATM 6710 C C3B . NAP F 2 .   ? -25.881 -36.654 37.717  1.00 72.90  ?  401 NAP C C3B 1 
HETATM 6711 O O3B . NAP F 2 .   ? -26.098 -37.729 36.813  1.00 72.02  ?  401 NAP C O3B 1 
HETATM 6712 C C2B . NAP F 2 .   ? -25.382 -37.131 39.071  1.00 73.11  ?  401 NAP C C2B 1 
HETATM 6713 O O2B . NAP F 2 .   ? -24.581 -38.265 38.764  1.00 69.35  ?  401 NAP C O2B 1 
HETATM 6714 C C1B . NAP F 2 .   ? -24.515 -35.957 39.524  1.00 72.73  ?  401 NAP C C1B 1 
HETATM 6715 N N9A . NAP F 2 .   ? -25.166 -34.948 40.352  1.00 75.46  ?  401 NAP C N9A 1 
HETATM 6716 C C8A . NAP F 2 .   ? -26.403 -34.370 40.179  1.00 75.57  ?  401 NAP C C8A 1 
HETATM 6717 N N7A . NAP F 2 .   ? -26.683 -33.461 41.084  1.00 74.94  ?  401 NAP C N7A 1 
HETATM 6718 C C5A . NAP F 2 .   ? -25.555 -33.428 41.899  1.00 77.45  ?  401 NAP C C5A 1 
HETATM 6719 C C6A . NAP F 2 .   ? -25.220 -32.667 43.042  1.00 77.80  ?  401 NAP C C6A 1 
HETATM 6720 N N6A . NAP F 2 .   ? -26.011 -31.744 43.581  1.00 78.90  ?  401 NAP C N6A 1 
HETATM 6721 N N1A . NAP F 2 .   ? -24.007 -32.886 43.608  1.00 79.70  ?  401 NAP C N1A 1 
HETATM 6722 C C2A . NAP F 2 .   ? -23.202 -33.808 43.064  1.00 75.12  ?  401 NAP C C2A 1 
HETATM 6723 N N3A . NAP F 2 .   ? -23.408 -34.579 41.998  1.00 79.43  ?  401 NAP C N3A 1 
HETATM 6724 C C4A . NAP F 2 .   ? -24.614 -34.339 41.453  1.00 75.64  ?  401 NAP C C4A 1 
HETATM 6725 O O3  . NAP F 2 .   ? -25.851 -33.532 33.266  1.00 70.53  ?  401 NAP C O3  1 
HETATM 6726 P PN  . NAP F 2 .   ? -24.993 -33.629 31.910  1.00 66.82  ?  401 NAP C PN  1 
HETATM 6727 O O1N . NAP F 2 .   ? -25.772 -33.031 30.781  1.00 65.41  ?  401 NAP C O1N 1 
HETATM 6728 O O2N . NAP F 2 .   ? -24.456 -35.010 31.745  1.00 59.83  ?  401 NAP C O2N 1 
HETATM 6729 O O5D . NAP F 2 .   ? -23.771 -32.681 32.292  1.00 67.48  ?  401 NAP C O5D 1 
HETATM 6730 C C5D . NAP F 2 .   ? -23.991 -31.270 32.359  1.00 68.72  ?  401 NAP C C5D 1 
HETATM 6731 C C4D . NAP F 2 .   ? -22.732 -30.642 32.888  1.00 69.03  ?  401 NAP C C4D 1 
HETATM 6732 O O4D . NAP F 2 .   ? -21.686 -30.808 31.905  1.00 63.79  ?  401 NAP C O4D 1 
HETATM 6733 C C3D . NAP F 2 .   ? -22.849 -29.153 33.229  1.00 72.69  ?  401 NAP C C3D 1 
HETATM 6734 O O3D . NAP F 2 .   ? -22.321 -28.923 34.528  1.00 78.71  ?  401 NAP C O3D 1 
HETATM 6735 C C2D . NAP F 2 .   ? -21.982 -28.477 32.167  1.00 69.50  ?  401 NAP C C2D 1 
HETATM 6736 O O2D . NAP F 2 .   ? -21.153 -27.504 32.780  1.00 68.26  ?  401 NAP C O2D 1 
HETATM 6737 C C1D . NAP F 2 .   ? -21.158 -29.564 31.492  1.00 61.02  ?  401 NAP C C1D 1 
HETATM 6738 N N1N . NAP F 2 .   ? -21.301 -29.487 30.015  1.00 64.20  ?  401 NAP C N1N 1 
HETATM 6739 C C2N . NAP F 2 .   ? -20.486 -28.662 29.282  1.00 65.88  ?  401 NAP C C2N 1 
HETATM 6740 C C3N . NAP F 2 .   ? -20.608 -28.603 27.896  1.00 62.92  ?  401 NAP C C3N 1 
HETATM 6741 C C7N . NAP F 2 .   ? -19.617 -27.788 27.107  1.00 65.08  ?  401 NAP C C7N 1 
HETATM 6742 O O7N . NAP F 2 .   ? -19.699 -27.782 25.879  1.00 65.70  ?  401 NAP C O7N 1 
HETATM 6743 N N7N . NAP F 2 .   ? -18.695 -27.109 27.783  1.00 61.57  ?  401 NAP C N7N 1 
HETATM 6744 C C4N . NAP F 2 .   ? -21.636 -29.303 27.275  1.00 66.50  ?  401 NAP C C4N 1 
HETATM 6745 C C5N . NAP F 2 .   ? -22.447 -30.129 28.025  1.00 61.91  ?  401 NAP C C5N 1 
HETATM 6746 C C6N . NAP F 2 .   ? -22.244 -30.226 29.385  1.00 65.39  ?  401 NAP C C6N 1 
HETATM 6747 P P2B . NAP F 2 .   ? -24.683 -39.378 39.935  1.00 76.24  ?  401 NAP C P2B 1 
HETATM 6748 O O1X . NAP F 2 .   ? -26.090 -39.946 39.854  1.00 82.46  ?  401 NAP C O1X 1 
HETATM 6749 O O2X . NAP F 2 .   ? -23.623 -40.429 39.654  1.00 76.63  ?  401 NAP C O2X 1 
HETATM 6750 O O3X . NAP F 2 .   ? -24.440 -38.670 41.260  1.00 80.39  ?  401 NAP C O3X 1 
HETATM 6751 O O   . HOH G 3 .   ? -22.419 -43.196 21.458  1.00 60.78  ?  501 HOH A O   1 
HETATM 6752 O O   . HOH G 3 .   ? 12.248  -20.222 12.375  1.00 60.06  ?  502 HOH A O   1 
HETATM 6753 O O   . HOH G 3 .   ? -18.961 -42.133 22.246  1.00 55.06  ?  503 HOH A O   1 
HETATM 6754 O O   . HOH G 3 .   ? -8.796  -10.867 36.656  1.00 70.64  ?  504 HOH A O   1 
HETATM 6755 O O   . HOH G 3 .   ? 11.377  -33.001 15.087  1.00 58.73  ?  505 HOH A O   1 
HETATM 6756 O O   . HOH G 3 .   ? 7.406   -22.886 -2.218  1.00 70.08  ?  506 HOH A O   1 
HETATM 6757 O O   . HOH G 3 .   ? -2.027  -1.029  27.380  1.00 65.64  ?  507 HOH A O   1 
HETATM 6758 O O   . HOH G 3 .   ? -4.091  -0.813  29.104  1.00 73.07  ?  508 HOH A O   1 
HETATM 6759 O O   . HOH H 3 .   ? 20.778  -52.986 40.224  1.00 61.82  ?  501 HOH B O   1 
HETATM 6760 O O   . HOH H 3 .   ? 22.486  -24.530 43.408  1.00 74.13  ?  502 HOH B O   1 
HETATM 6761 O O   . HOH H 3 .   ? 43.676  -53.912 18.079  1.00 58.14  ?  503 HOH B O   1 
HETATM 6762 O O   . HOH H 3 .   ? 30.182  -47.456 43.270  1.00 53.99  ?  504 HOH B O   1 
HETATM 6763 O O   . HOH H 3 .   ? 36.629  -42.431 11.651  1.00 67.55  ?  505 HOH B O   1 
HETATM 6764 O O   . HOH H 3 .   ? 41.117  -55.882 26.607  1.00 65.33  ?  506 HOH B O   1 
HETATM 6765 O O   . HOH H 3 .   ? 44.192  -17.617 39.614  1.00 71.85  ?  507 HOH B O   1 
HETATM 6766 O O   . HOH I 3 .   ? -19.029 -25.835 43.285  1.00 65.53  ?  501 HOH C O   1 
HETATM 6767 O O   . HOH I 3 .   ? -21.124 -14.948 18.430  1.00 61.59  ?  502 HOH C O   1 
HETATM 6768 O O   . HOH I 3 .   ? -14.346 -14.957 36.069  1.00 58.81  ?  503 HOH C O   1 
HETATM 6769 O O   . HOH I 3 .   ? -23.369 -14.625 11.078  1.00 65.36  ?  504 HOH C O   1 
HETATM 6770 O O   . HOH I 3 .   ? 12.532  -38.494 14.207  1.00 68.50  ?  505 HOH C O   1 
HETATM 6771 O O   . HOH I 3 .   ? -22.754 -36.674 33.576  1.00 55.11  ?  506 HOH C O   1 
HETATM 6772 O O   . HOH I 3 .   ? -7.791  -16.643 35.316  1.00 59.36  ?  507 HOH C O   1 
HETATM 6773 O O   . HOH I 3 .   ? -14.813 -16.602 29.386  1.00 59.58  ?  508 HOH C O   1 
HETATM 6774 O O   . HOH I 3 .   ? -25.356 -26.367 37.454  1.00 62.93  ?  509 HOH C O   1 
HETATM 6775 O O   . HOH I 3 .   ? 2.560   -35.698 22.449  1.00 57.03  ?  510 HOH C O   1 
HETATM 6776 O O   . HOH I 3 .   ? -12.119 -8.513  17.690  1.00 64.72  ?  511 HOH C O   1 
# 
